Start End HC(Spearman correlation) DM-DS(Spearman correlation) DM-LS(Spearman correlation) Significance of start Significance of end Datatype of start Datatype of end p.kruskal(start) p.kruskal(end) DM-DS vs HC(start) DM-LS vs HC(start) DM-LS vs DM-DS(start) DM-DS vs HC(end) DM-LS vs HC(end) DM-LS vs DM-DS(end) Adrenergic signaling in cardiomyocytes 12-HEPE+blood 0 0 -0.410535099 kegg serum_ARA NA 0.312 no no up no no no Aldosterone synthesis and secretion 12-HEPE+blood 0 0 -0.47272071 kegg serum_ARA NA 0.312 no up up no no no Amphetamine addiction 12-HEPE+blood 0 0 -0.527752225 kegg serum_ARA NA 0.312 no no no no no no Bifidobacterium 12-HEPE+blood 0 -0.606317072 0 acetate-producing Genus serum_ARA 0.105 0.312 no dn no no no no Calcium signaling pathway 12-HEPE+blood 0 0 -0.405582262 kegg serum_ARA NA 0.312 no up up no no no Carbon metabolism 12-HEPE+blood 0 0 0.412736359 kegg serum_ARA NA 0.312 no no no no no no Dopaminergic synapse 12-HEPE+blood 0 0 -0.458962831 kegg serum_ARA NA 0.312 no up no no no no ErbB signaling pathway 12-HEPE+blood 0 0.58677406 0 kegg serum_ARA NA 0.312 no no no no no no Fc epsilon RI signaling pathway 12-HEPE+blood 0 0 0.485928274 kegg serum_ARA NA 0.312 no no no no no no GnRH signaling pathway 12-HEPE+blood 0 0 -0.516195607 kegg serum_ARA NA 0.312 no no no no no no GUDCA+stool 12-HEPE+blood 0 0.646202371 0 yes stool_bileacids serum_ARA 0.0085 0.312 no dn no no no no Hepatocellular carcinoma 12-HEPE+blood 0 0 0.463365353 kegg serum_ARA NA 0.312 no no no no no no Inflammatory mediator regulation of TRP channels 12-HEPE+blood 0 0 -0.525550964 kegg serum_ARA NA 0.312 no no no no no no Lysosome 12-HEPE+blood 0 0 0.477123231 kegg serum_ARA NA 0.312 no no no no no no Neuroactive ligand-receptor interaction 12-HEPE+blood 0 0 0.442453377 kegg serum_ARA NA 0.312 up up up no no no Non-small cell lung cancer 12-HEPE+blood 0 0.526370848 0 kegg serum_ARA NA 0.312 no no no no no no Peroxisome 12-HEPE+blood 0 0 0.421541402 kegg serum_ARA NA 0.312 no no no no no no Proteasome 12-HEPE+blood 0 -0.500483757 0 kegg serum_ARA NA 0.312 no no no no no no Renin secretion 12-HEPE+blood 0 -0.517741818 0 kegg serum_ARA NA 0.312 no no no no no no 11-HETE+blood 12-ketoDCA+blood 0 -0.551028023 0 serum_ARA serum_bileacids 0.464 0.517 no no no no no no Acetic acid+stool 12-ketoDCA+blood 0 0 -0.449941231 yes stool_scfa serum_bileacids 0.0656 0.517 dn no no no no no Alistipes 12-ketoDCA+blood 0 0 0.413298925 Genus serum_bileacids 0.0114 0.517 no up no no no no AMPK signaling pathway 12-ketoDCA+blood 0.528812891 0 0 kegg serum_bileacids NA 0.517 no no no no no no Anaerostipes 12-ketoDCA+blood 0.476855169 0 0 butyrate-producing Genus serum_bileacids 0.568 0.517 no no no no no no Bifidobacterium 12-ketoDCA+blood -0.45457709 0 0 acetate-producing Genus serum_bileacids 0.105 0.517 no dn no no no no Butyric acid+stool 12-ketoDCA+blood 0 0 -0.532871576 yes stool_scfa serum_bileacids 0.102 0.517 dn no no no no no Calcium signaling pathway 12-ketoDCA+blood 0 0.537084017 0 kegg serum_bileacids NA 0.517 no up up no no no Chemokine signaling pathway 12-ketoDCA+blood 0 0 0.400576758 kegg serum_bileacids NA 0.517 no no no no no no Clostridium 12-ketoDCA+blood 0 -0.573275344 0 Genus serum_bileacids 0.925 0.517 no no no no no no Cushing syndrome 12-ketoDCA+blood 0 0.500376836 0 kegg serum_bileacids NA 0.517 no no up no no no Cytokine-cytokine receptor interaction 12-ketoDCA+blood 0 0 0.576024902 kegg serum_bileacids NA 0.517 no no no no no no Endocrine resistance 12-ketoDCA+blood 0 0.550607716 0 kegg serum_bileacids NA 0.517 no no no no no no Estrogen signaling pathway 12-ketoDCA+blood 0 0 0.460103807 kegg serum_bileacids NA 0.517 no no no no no no GCA+stool 12-ketoDCA+blood 0 -0.606779876 0 stool_bileacids serum_bileacids 0.0809 0.517 no no no no no no GnRH signaling pathway 12-ketoDCA+blood 0 0.600838595 0 kegg serum_bileacids NA 0.517 no no no no no no L-Phenylalanine+stool 12-ketoDCA+blood -0.644251775 0 0 stool_cometabolism serum_bileacids 0.398 0.517 no no no no no no L-Tryptophan+stool 12-ketoDCA+blood -0.711361335 0 0 stool_cometabolism serum_bileacids 0.557 0.517 no no no no no no L-Tyrosine+stool 12-ketoDCA+blood -0.671095599 0 0 stool_cometabolism serum_bileacids 0.44 0.517 no no no no no no Longevity regulating pathway - multiple species 12-ketoDCA+blood 0 -0.527424233 0 kegg serum_bileacids NA 0.517 no no no no no no mTOR signaling pathway 12-ketoDCA+blood 0.489459373 0 0 kegg serum_bileacids NA 0.517 no no no no no no Prevotella 12-ketoDCA+blood 0.516526535 0 0 acetate-producing Genus serum_bileacids 0.287 0.517 no no no no no no Regulation of actin cytoskeleton 12-ketoDCA+blood 0 -0.502308793 0 kegg serum_bileacids NA 0.517 no no no no no no Renin secretion 12-ketoDCA+blood 0 0 0.409975765 kegg serum_bileacids NA 0.517 no no no no no no RNA transport 12-ketoDCA+blood 0.459944235 0 0 kegg serum_bileacids NA 0.517 no no no no no no Salivary secretion 12-ketoDCA+blood 0 0 0.441753363 kegg serum_bileacids NA 0.517 no no no no no no T cell receptor signaling pathway 12-ketoDCA+blood 0 0.525492276 0 kegg serum_bileacids NA 0.517 no no no no no no TDCA+stool 12-ketoDCA+blood 0 -0.690065559 0 stool_bileacids serum_bileacids 0.963 0.517 no no no no no no total_stool_cometabolism+stool 12-ketoDCA+blood -0.691228467 0 0 stool_cometabolism serum_bileacids 0.707 0.517 no no no no no no total_stool_scfa+stool 12-ketoDCA+blood 0 0 -0.472879412 stool_scfa serum_bileacids 0.0534 0.517 dn no up no no no Viral protein interaction with cytokine and cytokine receptor 12-ketoDCA+blood 0 0 0.405500047 kegg serum_bileacids NA 0.517 no no no no no no Akkermansia 12-ketoDCA+stool 0 0 0.632422322 acetate-producing Genus stool_bileacids 0.23 0.505 no no no no no no Alistipes 12-ketoDCA+stool 0 0 0.419515898 Genus stool_bileacids 0.0114 0.505 no up no no no no Allograft rejection 12-ketoDCA+stool 0 -0.806380224 0 kegg stool_bileacids NA 0.505 no no no no no no Antigen processing and presentation 12-ketoDCA+stool 0 -0.788156942 0.422924901 kegg stool_bileacids NA 0.505 no no no no no no Apoptosis 12-ketoDCA+stool -0.570691434 0 0 kegg stool_bileacids NA 0.505 no no no no no no Autoimmune thyroid disease 12-ketoDCA+stool 0 -0.806380224 0 kegg stool_bileacids NA 0.505 no no no no no no Blautia 12-ketoDCA+stool 0 0 -0.434223753 acetate-producing Genus stool_bileacids 1.36E-05 0.505 up dn dn no no no Breast cancer 12-ketoDCA+stool 0 0.706152174 0 kegg stool_bileacids NA 0.505 no no no no no no Carbon metabolism 12-ketoDCA+stool 0 -0.615035764 0 kegg stool_bileacids NA 0.505 no no no no no no Cell adhesion molecules 12-ketoDCA+stool 0 -0.719819635 0 kegg stool_bileacids NA 0.505 no no no no no no Cellular senescence 12-ketoDCA+stool 0 -0.756266199 0 kegg stool_bileacids NA 0.505 no no no no no no Chemical carcinogenesis - receptor activation 12-ketoDCA+stool 0 0.760822019 0 kegg stool_bileacids NA 0.505 no no no no no no Choline metabolism in cancer 12-ketoDCA+stool 0 0.719819635 0 kegg stool_bileacids NA 0.505 no no no no no no Cholinergic synapse 12-ketoDCA+stool 0 0.615035764 0 kegg stool_bileacids NA 0.505 no no no no no no Colorectal cancer 12-ketoDCA+stool 0 0.610479944 0 kegg stool_bileacids NA 0.505 no no no no no no Cortisol synthesis and secretion 12-ketoDCA+stool 0 0.615035764 0 kegg stool_bileacids NA 0.505 no no up no no no Cushing syndrome 12-ketoDCA+stool 0 0.651482328 0 kegg stool_bileacids NA 0.505 no no up no no no Endocrine resistance 12-ketoDCA+stool 0 0.724375456 0 kegg stool_bileacids NA 0.505 no no no no no no Endocytosis 12-ketoDCA+stool 0 -0.728931276 0 kegg stool_bileacids NA 0.505 no no no no no no Epstein-Barr virus infection 12-ketoDCA+stool 0 -0.683373071 0 kegg stool_bileacids NA 0.505 no no no no no no Estrogen signaling pathway 12-ketoDCA+stool 0 0 0.483907397 kegg stool_bileacids NA 0.505 no no no no no no Fc epsilon RI signaling pathway 12-ketoDCA+stool 0 0 -0.43083004 kegg stool_bileacids NA 0.505 no no no no no no GnRH signaling pathway 12-ketoDCA+stool 0 0.646926508 0 kegg stool_bileacids NA 0.505 no no no no no no Graft-versus-host disease 12-ketoDCA+stool 0 -0.806380224 0 kegg stool_bileacids NA 0.505 no no no no no no Herpes simplex virus 1 infection 12-ketoDCA+stool 0 -0.701596353 0 kegg stool_bileacids NA 0.505 no no no no no no Human cytomegalovirus infection 12-ketoDCA+stool 0 -0.692484712 0 kegg stool_bileacids NA 0.505 no no dn no no no Human immunodeficiency virus 1 infection 12-ketoDCA+stool 0 -0.683373071 0 kegg stool_bileacids NA 0.505 no no no no no no Human papillomavirus infection 12-ketoDCA+stool 0 -0.715263815 0 kegg stool_bileacids NA 0.505 no no no no no no Human T-cell leukemia virus 1 infection 12-ketoDCA+stool 0 -0.742598738 0 kegg stool_bileacids NA 0.505 no no no no no no Legionellosis 12-ketoDCA+stool 0 0 0.539243365 kegg stool_bileacids NA 0.505 no no no no no no Leishmaniasis 12-ketoDCA+stool 0 0 0.521174478 kegg stool_bileacids NA 0.505 no no no no no no Leukocyte transendothelial migration 12-ketoDCA+stool 0 -0.628703226 0 kegg stool_bileacids NA 0.505 no no no no no no Lipid and atherosclerosis 12-ketoDCA+stool -0.469556244 0 0 kegg stool_bileacids NA 0.505 no no no no no no Longevity regulating pathway 12-ketoDCA+stool 0 0.706152174 0 kegg stool_bileacids NA 0.505 no no no no no no Longevity regulating pathway - multiple species 12-ketoDCA+stool 0 0 0.557312253 kegg stool_bileacids NA 0.505 no no no no no no Mitophagy - animal 12-ketoDCA+stool 0 0 0.426312818 kegg stool_bileacids NA 0.505 no no no no no no Natural killer cell mediated cytotoxicity 12-ketoDCA+stool 0 -0.756266199 0 kegg stool_bileacids NA 0.505 no no no no no no NOD-like receptor signaling pathway 12-ketoDCA+stool 0 0 0.45567476 kegg stool_bileacids NA 0.505 no no no no no no Odoribacter 12-ketoDCA+stool 0 -0.644484351 0 butyrate-producing Genus stool_bileacids 0.798 0.505 no no no no no no p53 signaling pathway 12-ketoDCA+stool 0 0.76993366 0 kegg stool_bileacids NA 0.505 no no no no no no Pathogenic Escherichia coli infection 12-ketoDCA+stool -0.479876161 -0.642370687 0 kegg stool_bileacids NA 0.505 no no no no no no Pathways in cancer 12-ketoDCA+stool 0 0.628703226 0 kegg stool_bileacids NA 0.505 no no no no no no Phagosome 12-ketoDCA+stool 0 -0.646926508 0 kegg stool_bileacids NA 0.505 no no no no no no Protein processing in endoplasmic reticulum 12-ketoDCA+stool 0 0 0.504234896 kegg stool_bileacids NA 0.505 no no no no no no Purine metabolism 12-ketoDCA+stool 0.543859649 0 0 kegg stool_bileacids NA 0.505 no no no no no no Renin secretion 12-ketoDCA+stool 0 0 0.426312818 kegg stool_bileacids NA 0.505 no no no no no no Salmonella infection 12-ketoDCA+stool 0 -0.756266199 0 kegg stool_bileacids NA 0.505 no no no no no no Shigellosis 12-ketoDCA+stool 0 0 0.47826087 kegg stool_bileacids NA 0.505 no no no no no no Signaling pathways regulating pluripotency of stem cells 12-ketoDCA+stool 0 0.660593969 0 kegg stool_bileacids NA 0.505 no no no no no no Thyroid hormone synthesis 12-ketoDCA+stool 0.475748194 0 0 kegg stool_bileacids NA 0.505 no no no no no no Type I diabetes mellitus 12-ketoDCA+stool 0 -0.806380224 0 kegg stool_bileacids NA 0.505 no no no no no no Ubiquitin mediated proteolysis 12-ketoDCA+stool 0 0 0.456804065 kegg stool_bileacids NA 0.505 no no no no no no Viral carcinogenesis 12-ketoDCA+stool 0 -0.651482328 0 kegg stool_bileacids NA 0.505 no no no no no no Viral myocarditis 12-ketoDCA+stool 0 -0.810936045 0 kegg stool_bileacids NA 0.505 no no no no no no Yersinia infection 12-ketoDCA+stool -0.531475748 -0.633259046 0 kegg stool_bileacids NA 0.505 no no no no no no 4-hydroxybenzoic acid+stool "12,13-EPOME+blood" 0 0 -0.451439041 stool_cometabolism serum_ARA 0.0536 0.901 no dn no no no no AGE-RAGE signaling pathway in diabetic complications "12,13-EPOME+blood" 0 0 0.519313272 kegg serum_ARA NA 0.901 no no no no no no AMPK signaling pathway "12,13-EPOME+blood" -0.526739424 0 0 kegg serum_ARA NA 0.901 no no no no no no Antigen processing and presentation "12,13-EPOME+blood" 0.491499814 0 0 kegg serum_ARA NA 0.901 no no no no no no Arachidonic acid metabolism "12,13-EPOME+blood" 0 0 -0.617444375 kegg serum_ARA NA 0.901 no no no no no no Arginine and proline metabolism "12,13-EPOME+blood" 0.52859414 0 0 kegg serum_ARA NA 0.901 no up no no no no Breast cancer "12,13-EPOME+blood" 0 0 0.417708501 kegg serum_ARA NA 0.901 no no no no no no Butyricicoccus "12,13-EPOME+blood" 0 0.493492183 0 butyrate-producing Genus serum_ARA 0.852 0.901 no no no no no no Cell cycle "12,13-EPOME+blood" 0 0 0.427261087 kegg serum_ARA NA 0.901 no no no no no no Choline metabolism in cancer "12,13-EPOME+blood" 0 -0.575295083 0.472418763 kegg serum_ARA NA 0.901 no no no no no no Cholinergic synapse "12,13-EPOME+blood" 0 0 0.414234834 kegg serum_ARA NA 0.901 no no no no no no Clostridium "12,13-EPOME+blood" 0 0.643797615 0 Genus serum_ARA 0.925 0.901 no no no no no no Colorectal cancer "12,13-EPOME+blood" 0 0 0.495866017 kegg serum_ARA NA 0.901 no no no no no no Cushing syndrome "12,13-EPOME+blood" -0.506337545 0 0 kegg serum_ARA NA 0.901 no no up no no no DCA+stool "12,13-EPOME+blood" 0 0 0.532086261 stool_bileacids serum_ARA 0.195 0.901 no no no no no no ErbB signaling pathway "12,13-EPOME+blood" 0 -0.507346845 0.484576598 kegg serum_ARA NA 0.901 no no no no no no Ferroptosis "12,13-EPOME+blood" 0 0 -0.497602851 kegg serum_ARA NA 0.901 no no no no no no FoxO signaling pathway "12,13-EPOME+blood" 0 -0.513386688 0 kegg serum_ARA NA 0.901 no no no no no no GABAergic synapse "12,13-EPOME+blood" 0.504482828 0 0 kegg serum_ARA NA 0.901 no up up no no no Gap junction "12,13-EPOME+blood" 0 0 -0.417708501 kegg serum_ARA NA 0.901 no no no no no no Gastric cancer "12,13-EPOME+blood" 0 -0.546605827 0.484576598 kegg serum_ARA NA 0.901 no no no no no no Gemmiger "12,13-EPOME+blood" 0 -0.543731339 0 butyrate-producing Genus serum_ARA 0.595 0.901 no no no no no no Glioma "12,13-EPOME+blood" 0 0 0.506287019 kegg serum_ARA NA 0.901 no no no no no no Glutamatergic synapse "12,13-EPOME+blood" 0 0 -0.479366097 kegg serum_ARA NA 0.901 no up up no no no Glutathione metabolism "12,13-EPOME+blood" 0 0 -0.515839605 kegg serum_ARA NA 0.901 no no no no no no "Glycine, serine and threonine metabolism" "12,13-EPOME+blood" 0 0 -0.402076998 kegg serum_ARA NA 0.901 no up no no no no HDCA+stool "12,13-EPOME+blood" 0 0 0.496861038 stool_bileacids serum_ARA 0.176 0.901 no no no no no no Hepatitis B "12,13-EPOME+blood" 0 0 0.401208581 kegg serum_ARA NA 0.901 no no no no no no Hepatitis C "12,13-EPOME+blood" 0 0 0.400340165 kegg serum_ARA NA 0.901 no no no no no no Herpes simplex virus 1 infection "12,13-EPOME+blood" 0.46367907 0 0 kegg serum_ARA NA 0.901 no no no no no no Insulin resistance "12,13-EPOME+blood" 0 -0.536036101 0.533207942 kegg serum_ARA NA 0.901 no no no no no no JAK-STAT signaling pathway "12,13-EPOME+blood" 0 -0.513386688 0 kegg serum_ARA NA 0.901 no no no no no no Kaposi sarcoma-associated herpesvirus infection "12,13-EPOME+blood" 0 0 -0.409024333 kegg serum_ARA NA 0.901 no no dn no no no LCA+stool "12,13-EPOME+blood" 0 0 0.462562795 stool_bileacids serum_ARA 0.314 0.901 no no no no no no Lipid and atherosclerosis "12,13-EPOME+blood" 0.617620521 0 0 kegg serum_ARA NA 0.901 no no no no no no Long-term potentiation "12,13-EPOME+blood" 0 0 0.408155916 kegg serum_ARA NA 0.901 no no up no no no Malaria "12,13-EPOME+blood" 0 0 -0.486313432 kegg serum_ARA NA 0.901 no no no no no no MAPK signaling pathway "12,13-EPOME+blood" 0 0 0.416840085 kegg serum_ARA NA 0.901 no no no no no no MicroRNAs in cancer "12,13-EPOME+blood" 0 0 0.549707862 kegg serum_ARA NA 0.901 no no no no no no Mineral absorption "12,13-EPOME+blood" 0 0 -0.481971348 kegg serum_ARA NA 0.901 no no no no no no Mitophagy - animal "12,13-EPOME+blood" -0.511901693 0 -0.424655836 kegg serum_ARA NA 0.901 no no no no no no Necroptosis "12,13-EPOME+blood" 0 0 -0.464603011 kegg serum_ARA NA 0.901 no no no no no no NOD-like receptor signaling pathway "12,13-EPOME+blood" 0.497063963 0 0 kegg serum_ARA NA 0.901 no no no no no no Non-small cell lung cancer "12,13-EPOME+blood" 0 -0.549625748 0.456787259 kegg serum_ARA NA 0.901 no no no no no no Oxytocin signaling pathway "12,13-EPOME+blood" 0 0 -0.467208261 kegg serum_ARA NA 0.901 no no no no no no Pancreatic cancer "12,13-EPOME+blood" 0 0 0.444629424 kegg serum_ARA NA 0.901 no no no no no no Parkinson disease "12,13-EPOME+blood" 0 0 -0.401208581 kegg serum_ARA NA 0.901 no no no no no no Pathways in cancer "12,13-EPOME+blood" 0 -0.540565983 0.476760847 kegg serum_ARA NA 0.901 no no no no no no Pathways of neurodegeneration - multiple diseases "12,13-EPOME+blood" 0 0 -0.440287339 kegg serum_ARA NA 0.901 no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer "12,13-EPOME+blood" 0 0 0.570549866 kegg serum_ARA NA 0.901 no no no no no no Peroxisome "12,13-EPOME+blood" 0.515611126 0 0 kegg serum_ARA NA 0.901 no no no no no no Pertussis "12,13-EPOME+blood" 0.485935665 0 0 kegg serum_ARA NA 0.901 no no dn no no no Phosphatidylinositol signaling system "12,13-EPOME+blood" 0 0 0.565339365 kegg serum_ARA NA 0.901 no no no no no no Porphyrin and chlorophyll metabolism "12,13-EPOME+blood" 0 0 -0.434208421 kegg serum_ARA NA 0.901 no no no no no no Progesterone-mediated oocyte maturation "12,13-EPOME+blood" 0 0 0.424655836 kegg serum_ARA NA 0.901 no no no no no no Prolactin signaling pathway "12,13-EPOME+blood" 0 0 0.434208421 kegg serum_ARA NA 0.901 no no no no no no Prostate cancer "12,13-EPOME+blood" 0 0 0.413366417 kegg serum_ARA NA 0.901 no no no no no no Ribosome biogenesis in eukaryotes "12,13-EPOME+blood" 0 0 0.425524253 kegg serum_ARA NA 0.901 no no no no no no RNA degradation "12,13-EPOME+blood" 0 0 0.52539219 kegg serum_ARA NA 0.901 no no no no no no Ruminococcus "12,13-EPOME+blood" 0 0.65052357 0 Genus serum_ARA 0.0679 0.901 no no dn no no no Salivary secretion "12,13-EPOME+blood" 0 0 -0.422050586 kegg serum_ARA NA 0.901 no no no no no no Shigellosis "12,13-EPOME+blood" -0.4785168 0 -0.488918683 kegg serum_ARA NA 0.901 no no no no no no Signaling pathways regulating pluripotency of stem cells "12,13-EPOME+blood" 0 -0.529996257 0.455050426 kegg serum_ARA NA 0.901 no no no no no no Small cell lung cancer "12,13-EPOME+blood" 0 -0.549625748 0 kegg serum_ARA NA 0.901 no no up no no no Spinocerebellar ataxia "12,13-EPOME+blood" 0 0 0.501944935 kegg serum_ARA NA 0.901 no no no no no no Spliceosome "12,13-EPOME+blood" 0 0 0.464603011 kegg serum_ARA NA 0.901 no no no no no no Th1 and Th2 cell differentiation "12,13-EPOME+blood" 0 0 0.461129344 kegg serum_ARA NA 0.901 no no no no no no Th17 cell differentiation "12,13-EPOME+blood" 0 0 0.565339365 kegg serum_ARA NA 0.901 no no no no no no Thyroid hormone synthesis "12,13-EPOME+blood" 0 0 -0.477629264 kegg serum_ARA NA 0.901 no no no no no no Tight junction "12,13-EPOME+blood" 0 0.5707652 0 kegg serum_ARA NA 0.901 no no no no no no Transcriptional misregulation in cancer "12,13-EPOME+blood" 0 0 0.420313752 kegg serum_ARA NA 0.901 no no no no no no Ubiquitin mediated proteolysis "12,13-EPOME+blood" -0.510046977 0 0 kegg serum_ARA NA 0.901 no no no no no no Wnt signaling pathway "12,13-EPOME+blood" 0 0 0.481971348 kegg serum_ARA NA 0.901 no no no no no no 11-HETE+blood 13-HODE+blood 0 0 -0.489187164 serum_ARA serum_ARA 0.464 0.32 no no no no no no "12,13-EPOME+blood" 13-HODE+blood 0 0 0.495991738 serum_ARA serum_ARA 0.901 0.32 no no no no no no Adrenergic signaling in cardiomyocytes 13-HODE+blood 0.5 0 -0.413846154 kegg serum_ARA NA 0.32 no no up no no no Alcoholism 13-HODE+blood 0 0 -0.523846154 kegg serum_ARA NA 0.32 no no no no no no Amphetamine addiction 13-HODE+blood 0 0 -0.425384615 kegg serum_ARA NA 0.32 no no no no no no Bifidobacterium 13-HODE+blood 0.505453214 0 0 acetate-producing Genus serum_ARA 0.105 0.32 no dn no no no no Central carbon metabolism in cancer 13-HODE+blood 0 -0.676470588 0 kegg serum_ARA NA 0.32 no no no no no no Chemokine signaling pathway 13-HODE+blood 0 0.588235294 0 kegg serum_ARA NA 0.32 no no no no no no Circadian entrainment 13-HODE+blood 0 0 -0.5 kegg serum_ARA NA 0.32 no up up no no no Dopaminergic synapse 13-HODE+blood 0 0 -0.491538462 kegg serum_ARA NA 0.32 no up no no no no Endocrine and other factor-regulated calcium reabsorption 13-HODE+blood 0 0 -0.44 kegg serum_ARA NA 0.32 no no no no no no Ferroptosis 13-HODE+blood 0 0 -0.514615385 kegg serum_ARA NA 0.32 no no no no no no FoxO signaling pathway 13-HODE+blood 0 0 0.414615385 kegg serum_ARA NA 0.32 no no no no no no Gap junction 13-HODE+blood 0 0.514705882 0 kegg serum_ARA NA 0.32 no no no no no no JAK-STAT signaling pathway 13-HODE+blood 0 0 0.512307692 kegg serum_ARA NA 0.32 no no no no no no Lachnospira 13-HODE+blood -0.511278195 0 0 butyrate-producing Genus serum_ARA 0.279 0.32 no no no no no no Long-term depression 13-HODE+blood 0 0 -0.437692308 kegg serum_ARA NA 0.32 no no no no no no Long-term potentiation 13-HODE+blood 0.477192982 0 0 kegg serum_ARA NA 0.32 no no up no no no Mineral absorption 13-HODE+blood 0 0 -0.524615385 kegg serum_ARA NA 0.32 no no no no no no Morphine addiction 13-HODE+blood 0 0 -0.449230769 kegg serum_ARA NA 0.32 no up up no no no Necroptosis 13-HODE+blood 0 0 -0.472307692 kegg serum_ARA NA 0.32 no no no no no no NOD-like receptor signaling pathway 13-HODE+blood 0 0 0.489230769 kegg serum_ARA NA 0.32 no no no no no no nutriCA+stool 13-HODE+blood 0 -0.688102353 0 stool_bileacids serum_ARA 0.481 0.32 no no no no no no Pancreatic secretion 13-HODE+blood 0 0 -0.442307692 kegg serum_ARA NA 0.32 no no no no no no Paraprevotella 13-HODE+blood 0.475238873 0 0 Genus serum_ARA 0.118 0.32 no no no no no no Relaxin signaling pathway 13-HODE+blood 0 0.523529412 0 kegg serum_ARA NA 0.32 no no no no no no Renin secretion 13-HODE+blood 0 0 -0.424615385 kegg serum_ARA NA 0.32 no no no no no no Vascular smooth muscle contraction 13-HODE+blood 0 0 -0.479230769 kegg serum_ARA NA 0.32 no no no no no no Vasopressin-regulated water reabsorption 13-HODE+blood 0 0 -0.446923077 kegg serum_ARA NA 0.32 no no no no no no 14:0+blood 14:0-LPC+blood 0.610526316 0.492647059 0.802393162 yes serum_fattyacid serum_phospholipids 0.00572 0.00689 up no dn up up no 11-HETE+blood 14:0/16:0-PC+blood 0 0.671085173 0 serum_ARA serum_phospholipids 0.464 0.0358 no no no no up no 12-ketoDCA+blood 14:0/16:0-PC+blood 0.519474976 0 0 serum_bileacids serum_phospholipids 0.517 0.0358 no no no no up no 14:0-LPC+blood 14:0/16:0-PC+blood 0.457142857 0.507352941 0.742222222 serum_phospholipids serum_phospholipids 0.00689 0.0358 up up no no up no 14:0+blood 14:0/16:0-PC+blood 0 0.541666667 0.69982906 yes serum_fattyacid serum_phospholipids 0.00572 0.0358 up no dn no up no Bacterial invasion of epithelial cells 14:0/16:0-PC+blood 0 0 -0.507692308 kegg serum_phospholipids NA 0.0358 no no no no up no cGMP-PKG signaling pathway 14:0/16:0-PC+blood 0 0 -0.444615385 kegg serum_phospholipids NA 0.0358 no no no no up no Clostridium 14:0/16:0-PC+blood 0 0 -0.490268105 Genus serum_phospholipids 0.925 0.0358 no no no no up no Focal adhesion 14:0/16:0-PC+blood 0 0 -0.501538462 kegg serum_phospholipids NA 0.0358 no up up no up no Hippo signaling pathway 14:0/16:0-PC+blood 0 0 -0.457692308 kegg serum_phospholipids NA 0.0358 no no no no up no Hypertrophic cardiomyopathy 14:0/16:0-PC+blood 0 0 -0.431538462 kegg serum_phospholipids NA 0.0358 no up up no up no Kaposi sarcoma-associated herpesvirus infection 14:0/16:0-PC+blood 0 0 0.475384615 kegg serum_phospholipids NA 0.0358 no no dn no up no Leukocyte transendothelial migration 14:0/16:0-PC+blood 0 0 -0.469230769 kegg serum_phospholipids NA 0.0358 no no no no up no Malaria 14:0/16:0-PC+blood 0 0 0.450769231 kegg serum_phospholipids NA 0.0358 no no no no up no Mitophagy - animal 14:0/16:0-PC+blood 0 0 0.476923077 kegg serum_phospholipids NA 0.0358 no no no no up no Neuroactive ligand-receptor interaction 14:0/16:0-PC+blood 0 0 -0.493846154 kegg serum_phospholipids NA 0.0358 up up up no up no Odoribacter 14:0/16:0-PC+blood 0 0 -0.428675962 butyrate-producing Genus serum_phospholipids 0.798 0.0358 no no no no up no Parkinson disease 14:0/16:0-PC+blood 0 0 0.433846154 kegg serum_phospholipids NA 0.0358 no no no no up no Pathways of neurodegeneration - multiple diseases 14:0/16:0-PC+blood 0 0 0.451538462 kegg serum_phospholipids NA 0.0358 no no no no up no Platelet activation 14:0/16:0-PC+blood 0 0 -0.463076923 kegg serum_phospholipids NA 0.0358 no no no no up no Porphyrin and chlorophyll metabolism 14:0/16:0-PC+blood 0 0 0.421538462 kegg serum_phospholipids NA 0.0358 no no no no up no Purine metabolism 14:0/16:0-PC+blood 0 0 0.409230769 kegg serum_phospholipids NA 0.0358 no no no no up no Rap1 signaling pathway 14:0/16:0-PC+blood 0 0 -0.429230769 kegg serum_phospholipids NA 0.0358 no no no no up no Regulation of actin cytoskeleton 14:0/16:0-PC+blood 0 0 -0.47 kegg serum_phospholipids NA 0.0358 no no no no up no Salmonella infection 14:0/16:0-PC+blood 0 0 -0.47 kegg serum_phospholipids NA 0.0358 no no no no up no Sphingolipid signaling pathway 14:0/16:0-PC+blood 0 0 -0.461538462 kegg serum_phospholipids NA 0.0358 no no no no up no Ubiquitin mediated proteolysis 14:0/16:0-PC+blood 0 0 0.499230769 kegg serum_phospholipids NA 0.0358 no no no no up no 11-HETE+blood 14:0/18:0-PC+blood 0 0.72270711 0 serum_ARA serum_phospholipids 0.464 0.00289 no no no up up no 14:0-LPC+blood 14:0/18:0-PC+blood 0 0.514705882 0.530940171 serum_phospholipids serum_phospholipids 0.00689 0.00289 up up no up up no 14:0/16:0-PC+blood 14:0/18:0-PC+blood 0.530827068 0.784313725 0.798974359 serum_phospholipids serum_phospholipids 0.0358 0.00289 no up no up up no 14:0+blood 14:0/18:0-PC+blood 0 0 0.497435897 yes serum_fattyacid serum_phospholipids 0.00572 0.00289 up no dn up up no 14:0-LPC+blood 14:0/18:2-PC+blood 0.62556391 0.580882353 0.807863248 serum_phospholipids serum_phospholipids 0.00689 0.102 up up no no up no 14:0/16:0-PC+blood 14:0/18:2-PC+blood 0.571428571 0.568627451 0.648547009 serum_phospholipids serum_phospholipids 0.0358 0.102 no up no no up no 14:0+blood 14:0/18:2-PC+blood 0.538345865 0 0.783247863 yes serum_fattyacid serum_phospholipids 0.00572 0.102 up no dn no up no 3-(3-Hydroxyphenyl)propanoic acid+stool 14:0/18:2-PC+blood 0.565934066 0 0 stool_cometabolism serum_phospholipids 0.33 0.102 no no no no up no AMPK signaling pathway 14:0/18:2-PC+blood 0 0 0.488461538 kegg serum_phospholipids NA 0.102 no no no no up no Biosynthesis of cofactors 14:0/18:2-PC+blood 0 0 0.440769231 kegg serum_phospholipids NA 0.102 no no no no up no Blautia 14:0/18:2-PC+blood 0 -0.534313725 0 acetate-producing Genus serum_phospholipids 1.36E-05 0.102 up dn dn no up no Carbon metabolism 14:0/18:2-PC+blood 0 0 -0.437692308 kegg serum_phospholipids NA 0.102 no no no no up no cGMP-PKG signaling pathway 14:0/18:2-PC+blood 0 0 -0.678461538 kegg serum_phospholipids NA 0.102 no no no no up no Clostridium 14:0/18:2-PC+blood 0.45656265 0 -0.410375169 Genus serum_phospholipids 0.925 0.102 no no no no up no Coprococcus 14:0/18:2-PC+blood 0 -0.605392157 0 butyrate-producing Genus serum_phospholipids 0.612 0.102 no no no no up no Fc gamma R-mediated phagocytosis 14:0/18:2-PC+blood 0 0 -0.478461538 kegg serum_phospholipids NA 0.102 no no no no up no "Glycine, serine and threonine metabolism" 14:0/18:2-PC+blood 0 0 0.433076923 kegg serum_phospholipids NA 0.102 no up no no up no HIF-1 signaling pathway 14:0/18:2-PC+blood 0 0.564705882 0 kegg serum_phospholipids NA 0.102 no no no no up no IL-17 signaling pathway 14:0/18:2-PC+blood 0 0 -0.437692308 kegg serum_phospholipids NA 0.102 no no no no up no Legionellosis 14:0/18:2-PC+blood 0.568421053 0 0 kegg serum_phospholipids NA 0.102 no no no no up no Leishmaniasis 14:0/18:2-PC+blood 0.496491228 0 0 kegg serum_phospholipids NA 0.102 no no no no up no Lipid and atherosclerosis 14:0/18:2-PC+blood 0 0 -0.440769231 kegg serum_phospholipids NA 0.102 no no no no up no Longevity regulating pathway 14:0/18:2-PC+blood 0 0 0.473846154 kegg serum_phospholipids NA 0.102 no no no no up no Lysosome 14:0/18:2-PC+blood 0 0 -0.508461538 kegg serum_phospholipids NA 0.102 no no no no up no Neuroactive ligand-receptor interaction 14:0/18:2-PC+blood 0 0 -0.681538462 kegg serum_phospholipids NA 0.102 up up up no up no Neutrophil extracellular trap formation 14:0/18:2-PC+blood 0 0 -0.407692308 kegg serum_phospholipids NA 0.102 no no no no up no Pertussis 14:0/18:2-PC+blood 0 0 -0.400769231 kegg serum_phospholipids NA 0.102 no no dn no up no Phenylacetic acid+stool 14:0/18:2-PC+blood -0.648351648 0 0 stool_cometabolism serum_phospholipids 0.785 0.102 no no no no up no Porphyrin and chlorophyll metabolism 14:0/18:2-PC+blood 0 0 0.429230769 kegg serum_phospholipids NA 0.102 no no no no up no RNA transport 14:0/18:2-PC+blood 0.535087719 0 0 kegg serum_phospholipids NA 0.102 no no no no up no Slackia 14:0/18:2-PC+blood 0 0 0.50329385 Genus serum_phospholipids 0.94 0.102 no no no no up no Sphingolipid signaling pathway 14:0/18:2-PC+blood 0 0 -0.452307692 kegg serum_phospholipids NA 0.102 no no no no up no Tuberculosis 14:0/18:2-PC+blood 0 0 -0.411538462 kegg serum_phospholipids NA 0.102 no no dn no up no TUDCA+stool 14:0/18:2-PC+blood 0 -0.62122474 0 stool_bileacids serum_phospholipids 0.241 0.102 no no no no up no 14:0-LPC+blood 14:0/20:4-PC+blood 0.472180451 0 0.55008547 serum_phospholipids serum_phospholipids 0.00689 0.486 up up no no no no 14:0/16:0-PC+blood 14:0/20:4-PC+blood 0.607518797 0 0 serum_phospholipids serum_phospholipids 0.0358 0.486 no up no no no no 14:0/18:2-PC+blood 14:0/20:4-PC+blood 0.822556391 0.759803922 0.828376068 serum_phospholipids serum_phospholipids 0.102 0.486 no up no no no no 14:0+blood 14:0/20:4-PC+blood 0 0 0.467350427 yes serum_fattyacid serum_phospholipids 0.00572 0.486 up no dn no no no AMPK signaling pathway 14:0/20:4-PC+blood 0 0 0.407692308 kegg serum_phospholipids NA 0.486 no no no no no no Biosynthesis of cofactors 14:0/20:4-PC+blood 0 0 0.407692308 kegg serum_phospholipids NA 0.486 no no no no no no Blautia 14:0/20:4-PC+blood 0 0 0.416812058 acetate-producing Genus serum_phospholipids 1.36E-05 0.486 up dn dn no no no Butyricimonas 14:0/20:4-PC+blood 0 0 -0.4409344 butyrate-producing Genus serum_phospholipids 0.17 0.486 no no no no no no cGMP-PKG signaling pathway 14:0/20:4-PC+blood 0 0 -0.458461538 kegg serum_phospholipids NA 0.486 no no no no no no Clostridium 14:0/20:4-PC+blood 0 0 -0.401576387 Genus serum_phospholipids 0.925 0.486 no no no no no no IL-17 signaling pathway 14:0/20:4-PC+blood 0 0 -0.423076923 kegg serum_phospholipids NA 0.486 no no no no no no Lipid and atherosclerosis 14:0/20:4-PC+blood 0 0 -0.419230769 kegg serum_phospholipids NA 0.486 no no no no no no Lysosome 14:0/20:4-PC+blood 0 0 -0.418461538 kegg serum_phospholipids NA 0.486 no no no no no no Neuroactive ligand-receptor interaction 14:0/20:4-PC+blood 0 0 -0.557692308 kegg serum_phospholipids NA 0.486 up up up no no no Non-alcoholic fatty liver disease 14:0/20:4-PC+blood 0 0 0.453846154 kegg serum_phospholipids NA 0.486 no no no no no no Proteasome 14:0/20:4-PC+blood 0 0 -0.42 kegg serum_phospholipids NA 0.486 no no no no no no 11-HETE+blood 14:0+blood 0 0 -0.515760294 yes serum_ARA serum_fattyacid 0.464 0.00572 no no no up no dn 12-ketoDCA+blood 14:0+blood 0 -0.533495442 0 yes serum_bileacids serum_fattyacid 0.517 0.00572 no no no up no dn 3-(3-Hydroxyphenyl)propanoic acid+stool 14:0+blood 0.626373626 0 0 yes stool_cometabolism serum_fattyacid 0.33 0.00572 no no no up no dn Acetic acid+stool 14:0+blood 0 -0.663636364 0 yes yes stool_scfa serum_fattyacid 0.0656 0.00572 dn no no up no dn Adipocytokine signaling pathway 14:0+blood -0.542105263 0 0 yes kegg serum_fattyacid NA 0.00572 no no no up no dn Adlercreutzia 14:0+blood 0 0 -0.462614034 yes Genus serum_fattyacid 0.548 0.00572 no no no up no dn Amoebiasis 14:0+blood 0 0 -0.407692308 yes kegg serum_fattyacid NA 0.00572 no no no up no dn Bacteroides 14:0+blood 0 -0.485294118 0 LPS-producing yes Genus serum_fattyacid 0.000267 0.00572 dn dn up up no dn Central carbon metabolism in cancer 14:0+blood 0.592982456 0 0 yes kegg serum_fattyacid NA 0.00572 no no no up no dn cGMP-PKG signaling pathway 14:0+blood 0 0 -0.443076923 yes kegg serum_fattyacid NA 0.00572 no no no up no dn Focal adhesion 14:0+blood 0 0 -0.409230769 yes kegg serum_fattyacid NA 0.00572 no up up up no dn Glioma 14:0+blood 0 0.505882353 0 yes kegg serum_fattyacid NA 0.00572 no no no up no dn Leukocyte transendothelial migration 14:0+blood 0 0 -0.418461538 yes kegg serum_fattyacid NA 0.00572 no no no up no dn Phenylacetic acid+stool 14:0+blood 0 -0.618181818 0 yes stool_cometabolism serum_fattyacid 0.785 0.00572 no no no up no dn Porphyrin and chlorophyll metabolism 14:0+blood 0 0 0.413076923 yes kegg serum_fattyacid NA 0.00572 no no no up no dn Prevotella 14:0+blood 0 0.556188795 0 acetate-producing yes Genus serum_fattyacid 0.287 0.00572 no no no up no dn Rap1 signaling pathway 14:0+blood 0 0 -0.405384615 yes kegg serum_fattyacid NA 0.00572 no no no up no dn Sphingolipid signaling pathway 14:0+blood 0 0 -0.461538462 yes kegg serum_fattyacid NA 0.00572 no no no up no dn Th1 and Th2 cell differentiation 14:0+blood -0.533333333 0 0 yes kegg serum_fattyacid NA 0.00572 no no no up no dn Th17 cell differentiation 14:0+blood -0.457894737 0 0 yes kegg serum_fattyacid NA 0.00572 no no no up no dn 14:0-LPC+blood 14:1/18:2-PG+blood 0.833082707 0.74754902 0.817435897 serum_phospholipids serum_phospholipids 0.00689 0.00259 up up no no up up 14:0/16:0-PC+blood 14:1/18:2-PG+blood 0.586466165 0.546568627 0.555555556 serum_phospholipids serum_phospholipids 0.0358 0.00259 no up no no up up 14:0/18:2-PC+blood 14:1/18:2-PG+blood 0.606015038 0.573529412 0.819487179 serum_phospholipids serum_phospholipids 0.102 0.00259 no up no no up up 14:0/20:4-PC+blood 14:1/18:2-PG+blood 0.472180451 0 0.706666667 serum_phospholipids serum_phospholipids 0.486 0.00259 no no no no up up 14:0+blood 14:1/18:2-PG+blood 0 0.556372549 0.680683761 yes serum_fattyacid serum_phospholipids 0.00572 0.00259 up no dn no up up 12-ketoDCA+stool 15-HETE+blood -0.693660595 0 0 stool_bileacids serum_ARA 0.505 0.819 no no no no no no Amoebiasis 15-HETE+blood 0.486744724 0 0 kegg serum_ARA NA 0.819 no no no no no no Anaerostipes 15-HETE+blood 0 0 0.478536028 butyrate-producing Genus serum_ARA 0.568 0.819 no no no no no no Axon guidance 15-HETE+blood 0 0 0.441028959 kegg serum_ARA NA 0.819 no up up no no no Chemokine signaling pathway 15-HETE+blood 0.463734973 0 0 kegg serum_ARA NA 0.819 no no no no no no Gastric acid secretion 15-HETE+blood 0.460195012 0 0 kegg serum_ARA NA 0.819 no no no no no no Human papillomavirus infection 15-HETE+blood 0.469044916 0 0 kegg serum_ARA NA 0.819 no no no no no no Influenza A 15-HETE+blood 0.545154091 0 0 kegg serum_ARA NA 0.819 no no no no no no Legionellosis 15-HETE+blood -0.527454282 0 0 kegg serum_ARA NA 0.819 no no no no no no Leishmaniasis 15-HETE+blood -0.470814896 0 0 kegg serum_ARA NA 0.819 no no no no no no Leukocyte transendothelial migration 15-HETE+blood 0.571703803 0 0 kegg serum_ARA NA 0.819 no no no no no no Parabacteroides 15-HETE+blood 0 0 -0.465442864 Genus serum_ARA 4.19E-05 0.819 no up up no no no Phospholipase D signaling pathway 15-HETE+blood 0.513294436 0 0 kegg serum_ARA NA 0.819 no up up no no no Rap1 signaling pathway 15-HETE+blood 0.532764225 0 0 kegg serum_ARA NA 0.819 no no no no no no Regulation of actin cytoskeleton 15-HETE+blood 0 0 0.40857736 kegg serum_ARA NA 0.819 no no no no no no RNA transport 15-HETE+blood -0.492054666 0 0 kegg serum_ARA NA 0.819 no no no no no no Ruminococcus 15-HETE+blood 0 0 -0.404691701 Genus serum_ARA 0.0679 0.819 no no dn no no no Slackia 15-HETE+blood 0 0 -0.44060653 Genus serum_ARA 0.94 0.819 no no no no no no Spliceosome 15-HETE+blood -0.465504954 0 0 kegg serum_ARA NA 0.819 no no no no no no Th1 and Th2 cell differentiation 15-HETE+blood 0 0 -0.417960955 kegg serum_ARA NA 0.819 no no no no no no Th17 cell differentiation 15-HETE+blood 0 0 -0.415615056 kegg serum_ARA NA 0.819 no no no no no no Thyroid hormone signaling pathway 15-HETE+blood 0.492054666 0 0 kegg serum_ARA NA 0.819 no no no no no no Viral carcinogenesis 15-HETE+blood 0.523914321 0 0 kegg serum_ARA NA 0.819 no no no no no no Yersinia infection 15-HETE+blood 0.504444532 0 0 kegg serum_ARA NA 0.819 no no no no no no 11-HETE+blood 16:0-LPC+blood -0.479482077 0 0 serum_ARA serum_phospholipids 0.464 0.00456 no no no up up no 14:0-LPC+blood 16:0-LPC+blood 0 0 0.563760684 serum_phospholipids serum_phospholipids 0.00689 0.00456 up up no up up no 14:0/18:0-PC+blood 16:0-LPC+blood -0.494736842 0 0 serum_phospholipids serum_phospholipids 0.00289 0.00456 up up no up up no 14:1/18:2-PG+blood 16:0-LPC+blood 0 0 0.488547009 serum_phospholipids serum_phospholipids 0.00259 0.00456 no up up up up no ACA+stool 16:0-LPC+blood 0 0 0.534643732 stool_bileacids serum_phospholipids 0.417 0.00456 no no no up up no Adipocytokine signaling pathway 16:0-LPC+blood -0.459649123 0 0 kegg serum_phospholipids NA 0.00456 no no no up up no Amphetamine addiction 16:0-LPC+blood 0.529824561 0 0 kegg serum_phospholipids NA 0.00456 no no no up up no Butyricicoccus 16:0-LPC+blood -0.451705707 0 0 butyrate-producing Genus serum_phospholipids 0.852 0.00456 no no no up up no Butyricimonas 16:0-LPC+blood 0.469123886 0 0 butyrate-producing Genus serum_phospholipids 0.17 0.00456 no no no up up no Calcium signaling pathway 16:0-LPC+blood 0 0 0.43 kegg serum_phospholipids NA 0.00456 no up up up up no Carbon metabolism 16:0-LPC+blood 0 0 -0.547692308 kegg serum_phospholipids NA 0.00456 no no no up up no Cell cycle 16:0-LPC+blood 0.464912281 0 0 kegg serum_phospholipids NA 0.00456 no no no up up no Chemical carcinogenesis - receptor activation 16:0-LPC+blood 0.475438596 0 0 kegg serum_phospholipids NA 0.00456 no no no up up no Cortisol synthesis and secretion 16:0-LPC+blood 0 0 0.437692308 kegg serum_phospholipids NA 0.00456 no no up up up no Dorea 16:0-LPC+blood -0.464661654 0 0 Genus serum_phospholipids 0.00362 0.00456 up no dn up up no Endocrine and other factor-regulated calcium reabsorption 16:0-LPC+blood 0 0 0.429230769 kegg serum_phospholipids NA 0.00456 no no no up up no Endocrine resistance 16:0-LPC+blood 0.463157895 0 0 kegg serum_phospholipids NA 0.00456 no no no up up no Estrogen signaling pathway 16:0-LPC+blood 0.557894737 0 0 kegg serum_phospholipids NA 0.00456 no no no up up no Fusobacterium 16:0-LPC+blood 0 0.48659424 0 Genus serum_phospholipids 0.628 0.00456 no no no up up no Glucagon signaling pathway 16:0-LPC+blood 0.512280702 0 0 kegg serum_phospholipids NA 0.00456 no no no up up no Glycolysis / Gluconeogenesis 16:0-LPC+blood 0 0 -0.558461538 kegg serum_phospholipids NA 0.00456 no no no up up no HDCA+stool 16:0-LPC+blood 0 0 -0.458646617 stool_bileacids serum_phospholipids 0.176 0.00456 no no no up up no Inflammatory mediator regulation of TRP channels 16:0-LPC+blood 0.570175439 0 0 kegg serum_phospholipids NA 0.00456 no no no up up no Insulin secretion 16:0-LPC+blood 0 0 0.437692308 yes kegg serum_phospholipids NA 0.00456 no up up up up no Leukocyte transendothelial migration 16:0-LPC+blood 0 0 -0.420769231 kegg serum_phospholipids NA 0.00456 no no no up up no MAPK signaling pathway 16:0-LPC+blood 0 0 -0.488461538 kegg serum_phospholipids NA 0.00456 no no no up up no Morphine addiction 16:0-LPC+blood 0 0 0.426923077 kegg serum_phospholipids NA 0.00456 no up up up up no Parkinson disease 16:0-LPC+blood 0 0 0.542307692 kegg serum_phospholipids NA 0.00456 no no no up up no Pathways of neurodegeneration - multiple diseases 16:0-LPC+blood 0 0 0.560769231 kegg serum_phospholipids NA 0.00456 no no no up up no Ribosome biogenesis in eukaryotes 16:0-LPC+blood 0.50877193 0 0 kegg serum_phospholipids NA 0.00456 no no no up up no Roseburia 16:0-LPC+blood 0 0 -0.515213675 butyrate-producing Genus serum_phospholipids 0.495 0.00456 no no no up up no Salmonella infection 16:0-LPC+blood 0 0 -0.43 kegg serum_phospholipids NA 0.00456 no no no up up no Transcriptional misregulation in cancer 16:0-LPC+blood 0 0 0.450769231 kegg serum_phospholipids NA 0.00456 no no no up up no 13-HODE+blood 16:0-LPE+blood -0.490225564 0 0 serum_ARA serum_phospholipids 0.32 0.0711 no no no up up no 14:0/18:0-PC+blood 16:0-LPE+blood 0 0 0.535042735 serum_phospholipids serum_phospholipids 0.00289 0.0711 up up no up up no 14:0/20:4-PC+blood 16:0-LPE+blood 0 -0.634803922 0 serum_phospholipids serum_phospholipids 0.486 0.0711 no no no up up no 14:0/16:0-PC+blood 16:0/16:0-PC+blood 0.454135338 0 0 serum_phospholipids serum_phospholipids 0.0358 0.00079 no up no no up up 16:0/14:0-PC+blood 16:0/16:0-PC+blood 0.568421053 0.573529412 0.790769231 serum_phospholipids serum_phospholipids 0.0206 0.00079 no up up no up up Adherens junction 16:0/16:0-PC+blood 0 0 -0.486923077 kegg serum_phospholipids NA 0.00079 no no no no up up Alistipes 16:0/16:0-PC+blood 0 -0.523605249 0 Genus serum_phospholipids 0.0114 0.00079 no up no no up up Alzheimer disease 16:0/16:0-PC+blood 0 0 -0.415384615 kegg serum_phospholipids NA 0.00079 no no no no up up AMPK signaling pathway 16:0/16:0-PC+blood 0 -0.608823529 0 kegg serum_phospholipids NA 0.00079 no no no no up up Amyotrophic lateral sclerosis 16:0/16:0-PC+blood 0 0 -0.548461538 kegg serum_phospholipids NA 0.00079 no no no no up up Arrhythmogenic right ventricular cardiomyopathy 16:0/16:0-PC+blood 0 0 -0.511538462 kegg serum_phospholipids NA 0.00079 no up up no up up Bacterial invasion of epithelial cells 16:0/16:0-PC+blood 0 0 -0.453076923 kegg serum_phospholipids NA 0.00079 no no no no up up Butyric acid+stool 16:0/16:0-PC+blood 0.554945055 0 0 yes stool_scfa serum_phospholipids 0.102 0.00079 dn no no no up up Cardiac muscle contraction 16:0/16:0-PC+blood 0 0 -0.428461538 kegg serum_phospholipids NA 0.00079 no no up no up up Chemical carcinogenesis - receptor activation 16:0/16:0-PC+blood 0 0 0.433076923 kegg serum_phospholipids NA 0.00079 no no no no up up Coprococcus 16:0/16:0-PC+blood 0 0.504901961 0 butyrate-producing Genus serum_phospholipids 0.612 0.00079 no no no no up up Diabetic cardiomyopathy 16:0/16:0-PC+blood 0 0 -0.426153846 kegg serum_phospholipids NA 0.00079 no no no no up up Focal adhesion 16:0/16:0-PC+blood 0 0 -0.46 kegg serum_phospholipids NA 0.00079 no up up no up up HCA+stool 16:0/16:0-PC+blood 0 0 -0.553383459 stool_bileacids serum_phospholipids 0.155 0.00079 no no no no up up Hepatocellular carcinoma 16:0/16:0-PC+blood 0 0 -0.483846154 kegg serum_phospholipids NA 0.00079 no no no no up up Hippo signaling pathway 16:0/16:0-PC+blood 0 0 -0.504615385 kegg serum_phospholipids NA 0.00079 no no no no up up Huntington disease 16:0/16:0-PC+blood 0 0 -0.487692308 kegg serum_phospholipids NA 0.00079 no no no no up up Hypertrophic cardiomyopathy 16:0/16:0-PC+blood 0 0 -0.496153846 kegg serum_phospholipids NA 0.00079 no up up no up up Inflammatory mediator regulation of TRP channels 16:0/16:0-PC+blood 0 -0.523529412 0 kegg serum_phospholipids NA 0.00079 no no no no up up Influenza A 16:0/16:0-PC+blood 0 0.567647059 0 kegg serum_phospholipids NA 0.00079 no no no no up up L-Phenylalanine+stool 16:0/16:0-PC+blood 0 0 0.485714286 stool_cometabolism serum_phospholipids 0.398 0.00079 no no no no up up L-Tyrosine+stool 16:0/16:0-PC+blood 0 0 0.457142857 stool_cometabolism serum_phospholipids 0.44 0.00079 no no no no up up Longevity regulating pathway 16:0/16:0-PC+blood 0 -0.520588235 0 kegg serum_phospholipids NA 0.00079 no no no no up up Mineral absorption 16:0/16:0-PC+blood -0.533333333 0 0 kegg serum_phospholipids NA 0.00079 no no no no up up Necroptosis 16:0/16:0-PC+blood -0.515789474 0 0 kegg serum_phospholipids NA 0.00079 no no no no up up nutriCA+stool 16:0/16:0-PC+blood 0 0 -0.467669173 stool_bileacids serum_phospholipids 0.481 0.00079 no no no no up up Prevotella 16:0/16:0-PC+blood -0.454871493 0 0 acetate-producing Genus serum_phospholipids 0.287 0.00079 no no no no up up Prion disease 16:0/16:0-PC+blood 0 0 -0.476153846 kegg serum_phospholipids NA 0.00079 no no no no up up Progesterone-mediated oocyte maturation 16:0/16:0-PC+blood 0.478947368 0 0 kegg serum_phospholipids NA 0.00079 no no no no up up Propionic acid+stool 16:0/16:0-PC+blood 0 -0.645454545 0 yes stool_scfa serum_phospholipids 0.0436 0.00079 dn no up no up up Regulation of actin cytoskeleton 16:0/16:0-PC+blood 0 0 -0.462307692 kegg serum_phospholipids NA 0.00079 no no no no up up Salmonella infection 16:0/16:0-PC+blood 0 0.511764706 0 kegg serum_phospholipids NA 0.00079 no no no no up up Th1 and Th2 cell differentiation 16:0/16:0-PC+blood 0 0.617647059 0 kegg serum_phospholipids NA 0.00079 no no no no up up Th17 cell differentiation 16:0/16:0-PC+blood 0 0.514705882 0 kegg serum_phospholipids NA 0.00079 no no no no up up Thyroid hormone signaling pathway 16:0/16:0-PC+blood 0 0 -0.464615385 kegg serum_phospholipids NA 0.00079 no no no no up up Tight junction 16:0/16:0-PC+blood 0 0 -0.469230769 kegg serum_phospholipids NA 0.00079 no no no no up up UDCA+stool 16:0/16:0-PC+blood 0 0 -0.553383459 stool_bileacids serum_phospholipids 0.266 0.00079 no no no no up up Viral myocarditis 16:0/16:0-PC+blood 0 0.517647059 0 kegg serum_phospholipids NA 0.00079 no no no no up up 14:0-LPC+blood 16:0/16:0-PI+blood 0 0 0.763418803 serum_phospholipids serum_phospholipids 0.00689 0.358 up up no no no no 14:0/16:0-PC+blood 16:0/16:0-PI+blood 0 0 0.748376068 serum_phospholipids serum_phospholipids 0.0358 0.358 no up no no no no 14:0/18:0-PC+blood 16:0/16:0-PI+blood 0 0.740196078 0.541880342 serum_phospholipids serum_phospholipids 0.00289 0.358 up up no no no no 14:0/18:2-PC+blood 16:0/16:0-PI+blood 0 0 0.635555556 serum_phospholipids serum_phospholipids 0.102 0.358 no up no no no no 14:0/20:4-PC+blood 16:0/16:0-PI+blood 0 0 0.410598291 serum_phospholipids serum_phospholipids 0.486 0.358 no no no no no no 14:0+blood 16:0/16:0-PI+blood 0 0 0.616410256 yes serum_fattyacid serum_phospholipids 0.00572 0.358 up no dn no no no 14:1/18:2-PG+blood 16:0/16:0-PI+blood 0 0 0.692991453 serum_phospholipids serum_phospholipids 0.00259 0.358 no up up no no no 15-HETE+blood 16:0/16:0-PI+blood -0.500014349 0 0 serum_ARA serum_phospholipids 0.819 0.358 no no no no no no 16:0-LPE+blood 16:0/16:0-PI+blood 0.526315789 0 0 serum_phospholipids serum_phospholipids 0.0711 0.358 up up no no no no 11-HETE+blood 16:0/16:1-PC+blood 0 0.757121734 0 serum_ARA serum_phospholipids 0.464 0.00283 no no no up up no 12-ketoDCA+stool 16:0/16:1-PC+blood 0.626373626 0 0 stool_bileacids serum_phospholipids 0.505 0.00283 no no no up up no 14:0-LPC+blood 16:0/16:1-PC+blood 0 0 0.556923077 serum_phospholipids serum_phospholipids 0.00689 0.00283 up up no up up no 14:0/16:0-PC+blood 16:0/16:1-PC+blood 0.598496241 0.799019608 0.810598291 serum_phospholipids serum_phospholipids 0.0358 0.00283 no up no up up no 14:0/18:0-PC+blood 16:0/16:1-PC+blood 0.971428571 0.992647059 0.991111111 serum_phospholipids serum_phospholipids 0.00289 0.00283 up up no up up no 14:0/18:2-PC+blood 16:0/16:1-PC+blood 0 0 0.438632479 serum_phospholipids serum_phospholipids 0.102 0.00283 no up no up up no 14:0+blood 16:0/16:1-PC+blood 0 0 0.548034188 yes serum_fattyacid serum_phospholipids 0.00572 0.00283 up no dn up up no 14:1/18:2-PG+blood 16:0/16:1-PC+blood 0 0 0.402393162 serum_phospholipids serum_phospholipids 0.00259 0.00283 no up up up up no 16:0-LPC+blood 16:0/16:1-PC+blood -0.457142857 0 0 serum_phospholipids serum_phospholipids 0.00456 0.00283 up up no up up no 16:0-LPE+blood 16:0/16:1-PC+blood 0 0 0.542564103 serum_phospholipids serum_phospholipids 0.0711 0.00283 up up no up up no 16:0/16:0-PI+blood 16:0/16:1-PC+blood 0 0.725490196 0.576068376 serum_phospholipids serum_phospholipids 0.358 0.00283 no no no up up no 16:0+blood 16:0/16:1-PC+blood 0 0 0.605470085 yes serum_fattyacid serum_phospholipids 0.00876 0.00283 up no no up up no Axon guidance 16:0/16:1-PC+blood 0 0.547058824 0 kegg serum_phospholipids NA 0.00283 no up up up up no Bacterial invasion of epithelial cells 16:0/16:1-PC+blood 0 0 -0.420769231 kegg serum_phospholipids NA 0.00283 no no no up up no Butyricimonas 16:0/16:1-PC+blood -0.45101735 0 0 butyrate-producing Genus serum_phospholipids 0.17 0.00283 no no no up up no cAMP signaling pathway 16:0/16:1-PC+blood -0.492982456 0 0 yes kegg serum_phospholipids NA 0.00283 no up up up up no cGMP-PKG signaling pathway 16:0/16:1-PC+blood -0.533333333 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no Collinsella 16:0/16:1-PC+blood 0.481928257 0 0 Genus serum_phospholipids 0.128 0.00283 no no no up up no Dorea 16:0/16:1-PC+blood 0.547368421 0 0 Genus serum_phospholipids 0.00362 0.00283 up no dn up up no Epstein-Barr virus infection 16:0/16:1-PC+blood 0 0 0.400769231 kegg serum_phospholipids NA 0.00283 no no no up up no Fc epsilon RI signaling pathway 16:0/16:1-PC+blood -0.60877193 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no FoxO signaling pathway 16:0/16:1-PC+blood -0.543859649 0 -0.498461538 kegg serum_phospholipids NA 0.00283 no no no up up no GCDCA+stool 16:0/16:1-PC+blood 0 0.690909091 0 yes stool_bileacids serum_phospholipids 0.0471 0.00283 no dn no up up no Gemmiger 16:0/16:1-PC+blood 0.538345865 0 0 butyrate-producing Genus serum_phospholipids 0.595 0.00283 no no no up up no Glutathione metabolism 16:0/16:1-PC+blood 0.58245614 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no "Glycine, serine and threonine metabolism" 16:0/16:1-PC+blood 0.468421053 0 0 kegg serum_phospholipids NA 0.00283 no up no up up no Glycolysis / Gluconeogenesis 16:0/16:1-PC+blood 0.514035088 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no Hepatitis C 16:0/16:1-PC+blood -0.543859649 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no Human cytomegalovirus infection 16:0/16:1-PC+blood 0 0 0.403846154 kegg serum_phospholipids NA 0.00283 no no dn up up no Intestinal immune network for IgA production 16:0/16:1-PC+blood 0 0.511764706 0 kegg serum_phospholipids NA 0.00283 no no no up up no L-Phenylalanine+stool 16:0/16:1-PC+blood -0.747252747 0 0 stool_cometabolism serum_phospholipids 0.398 0.00283 no no no up up no L-Tryptophan+stool 16:0/16:1-PC+blood -0.593406593 0 0 stool_cometabolism serum_phospholipids 0.557 0.00283 no no no up up no L-Tyrosine+stool 16:0/16:1-PC+blood -0.582417582 0 0 stool_cometabolism serum_phospholipids 0.44 0.00283 no no no up up no Legionellosis 16:0/16:1-PC+blood 0.607017544 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no Leishmaniasis 16:0/16:1-PC+blood 0.594736842 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no Leukocyte transendothelial migration 16:0/16:1-PC+blood 0 0 -0.419230769 kegg serum_phospholipids NA 0.00283 no no no up up no MAPK signaling pathway 16:0/16:1-PC+blood 0 -0.664705882 0 kegg serum_phospholipids NA 0.00283 no no no up up no Olfactory transduction 16:0/16:1-PC+blood -0.510526316 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no Pancreatic cancer 16:0/16:1-PC+blood -0.622807018 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no Pathways in cancer 16:0/16:1-PC+blood -0.526315789 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no Phenylacetic acid+stool 16:0/16:1-PC+blood 0 -0.636363636 0 stool_cometabolism serum_phospholipids 0.785 0.00283 no no no up up no Phospholipase D signaling pathway 16:0/16:1-PC+blood -0.464912281 0 0 kegg serum_phospholipids NA 0.00283 no up up up up no Primary immunodeficiency 16:0/16:1-PC+blood 0 0 -0.456153846 kegg serum_phospholipids NA 0.00283 no no no up up no Prolactin signaling pathway 16:0/16:1-PC+blood -0.528070175 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no Purine metabolism 16:0/16:1-PC+blood 0.59122807 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no Rheumatoid arthritis 16:0/16:1-PC+blood 0.456140351 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no Roseburia 16:0/16:1-PC+blood 0 0.570202437 0 butyrate-producing Genus serum_phospholipids 0.495 0.00283 no no no up up no Salmonella infection 16:0/16:1-PC+blood 0 0 -0.415384615 kegg serum_phospholipids NA 0.00283 no no no up up no Sphingolipid signaling pathway 16:0/16:1-PC+blood -0.521052632 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no VEGF signaling pathway 16:0/16:1-PC+blood -0.559649123 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no Yersinia infection 16:0/16:1-PC+blood -0.464912281 0 0 kegg serum_phospholipids NA 0.00283 no no no up up no 11-HETE+blood 16:0/16:1-PI+blood 0 0.645274205 0 serum_ARA serum_phospholipids 0.464 0.262 no no no no no no 12-ketoDCA+blood 16:0/16:1-PI+blood 0.545287397 0 0 serum_bileacids serum_phospholipids 0.517 0.262 no no no no no no 14:0-LPC+blood 16:0/16:1-PI+blood 0.676691729 0 0.597264957 serum_phospholipids serum_phospholipids 0.00689 0.262 up up no no no no 14:0/16:0-PC+blood 16:0/16:1-PI+blood 0 0.573529412 0.631452991 serum_phospholipids serum_phospholipids 0.0358 0.262 no up no no no no 14:0/18:0-PC+blood 16:0/16:1-PI+blood 0 0.81372549 0.757948718 serum_phospholipids serum_phospholipids 0.00289 0.262 up up no no no no 14:1/18:2-PG+blood 16:0/16:1-PI+blood 0 0 0.424273504 serum_phospholipids serum_phospholipids 0.00259 0.262 no up up no no no 16:0-LPC+blood 16:0/16:1-PI+blood 0 0 0.434529915 serum_phospholipids serum_phospholipids 0.00456 0.262 up up no no no no 16:0-LPE+blood 16:0/16:1-PI+blood 0 0 0.541880342 serum_phospholipids serum_phospholipids 0.0711 0.262 up up no no no no 16:0/16:0-PI+blood 16:0/16:1-PI+blood 0.684210526 0.774509804 0.753846154 serum_phospholipids serum_phospholipids 0.358 0.262 no no no no no no 16:0/16:1-PC+blood 16:0/16:1-PI+blood 0 0.828431373 0.771623932 serum_phospholipids serum_phospholipids 0.00283 0.262 up up no no no no 16:0+blood 16:0/16:1-PI+blood 0 0 0.491282051 yes serum_fattyacid serum_phospholipids 0.00876 0.262 up no no no no no 16:0-LPE+blood 16:0/18:0-PC+blood 0 0 -0.416068376 serum_phospholipids serum_phospholipids 0.0711 0.521 up up no no no no 16:0/14:0-PC+blood 16:0/18:0-PC+blood 0 0 0.416068376 serum_phospholipids serum_phospholipids 0.0206 0.521 no up up no no no 16:0/16:0-PC+blood 16:0/18:0-PC+blood 0.663157895 0 0.450940171 serum_phospholipids serum_phospholipids 0.00079 0.521 no up up no no no 3-(3-Hydroxyphenyl)propanoic acid+stool 16:0/18:0-PC+blood 0 0 -0.603007519 stool_cometabolism serum_phospholipids 0.33 0.521 no no no no no no Adlercreutzia 16:0/18:0-PC+blood 0 0 0.489187164 Genus serum_phospholipids 0.548 0.521 no no no no no no Allograft rejection 16:0/18:0-PC+blood 0 0 -0.410769231 kegg serum_phospholipids NA 0.521 no no no no no no Autoimmune thyroid disease 16:0/18:0-PC+blood 0 0 -0.410769231 kegg serum_phospholipids NA 0.521 no no no no no no Graft-versus-host disease 16:0/18:0-PC+blood 0 0 -0.411538462 kegg serum_phospholipids NA 0.521 no no no no no no L-Phenylalanine+stool 16:0/18:0-PC+blood 0 0 0.476691729 stool_cometabolism serum_phospholipids 0.398 0.521 no no no no no no L-Tyrosine+stool 16:0/18:0-PC+blood 0 0 0.503759398 stool_cometabolism serum_phospholipids 0.44 0.521 no no no no no no Methanobrevibacter 16:0/18:0-PC+blood 0 0 0.537763232 Genus serum_phospholipids 0.629 0.521 no no no no no no Necroptosis 16:0/18:0-PC+blood -0.468421053 0 0 kegg serum_phospholipids NA 0.521 no no no no no no UDCA+stool 16:0/18:0-PC+blood 0 0 -0.458646617 stool_bileacids serum_phospholipids 0.266 0.521 no no no no no no Viral myocarditis 16:0/18:0-PC+blood 0 0 -0.460769231 kegg serum_phospholipids NA 0.521 no no no no no no 12-HEPE+blood 16:0/18:0-PS+blood -0.587799063 0 0 serum_ARA serum_phospholipids 0.312 0.377 no no no no no no 12-ketoDCA+blood 16:0/18:0-PS+blood 0 -0.602652259 0 serum_bileacids serum_phospholipids 0.517 0.377 no no no no no no 16:0-LPE+blood 16:0/18:0-PS+blood 0.448120301 0 0 serum_phospholipids serum_phospholipids 0.0711 0.377 up up no no no no 16:0/14:0-PC+blood 16:0/18:0-PS+blood 0 0 -0.540512821 serum_phospholipids serum_phospholipids 0.0206 0.377 no up up no no no Acetic acid+stool 16:0/18:0-PS+blood 0 -0.627272727 0 yes stool_scfa serum_phospholipids 0.0656 0.377 dn no no no no no Adipocytokine signaling pathway 16:0/18:0-PS+blood -0.540350877 -0.55 0 kegg serum_phospholipids NA 0.377 no no no no no no Calcium signaling pathway 16:0/18:0-PS+blood 0 -0.617647059 0 kegg serum_phospholipids NA 0.377 no up up no no no Carbon metabolism 16:0/18:0-PS+blood 0.461403509 0 0 kegg serum_phospholipids NA 0.377 no no no no no no Cytosolic DNA-sensing pathway 16:0/18:0-PS+blood 0 -0.526470588 0 kegg serum_phospholipids NA 0.377 no no no no no no DCA+stool 16:0/18:0-PS+blood 0 0 0.460150376 stool_bileacids serum_phospholipids 0.195 0.377 no no no no no no GCA+stool 16:0/18:0-PS+blood 0.598901099 0 0 stool_bileacids serum_phospholipids 0.0809 0.377 no no no no no no Glycolysis / Gluconeogenesis 16:0/18:0-PS+blood 0.492982456 0 0 kegg serum_phospholipids NA 0.377 no no no no no no Human cytomegalovirus infection 16:0/18:0-PS+blood 0 0 0.440769231 kegg serum_phospholipids NA 0.377 no no dn no no no Human immunodeficiency virus 1 infection 16:0/18:0-PS+blood 0 0 0.408461538 kegg serum_phospholipids NA 0.377 no no no no no no Human T-cell leukemia virus 1 infection 16:0/18:0-PS+blood 0 0 0.403076923 kegg serum_phospholipids NA 0.377 no no no no no no Intestinal immune network for IgA production 16:0/18:0-PS+blood -0.577192982 0 0 kegg serum_phospholipids NA 0.377 no no no no no no Kaposi sarcoma-associated herpesvirus infection 16:0/18:0-PS+blood -0.624561404 0 0 kegg serum_phospholipids NA 0.377 no no dn no no no Longevity regulating pathway - multiple species 16:0/18:0-PS+blood 0.612280702 0.508823529 0 kegg serum_phospholipids NA 0.377 no no no no no no Mitophagy - animal 16:0/18:0-PS+blood 0 -0.617647059 0 kegg serum_phospholipids NA 0.377 no no no no no no Necroptosis 16:0/18:0-PS+blood -0.464912281 0 0 kegg serum_phospholipids NA 0.377 no no no no no no Primary immunodeficiency 16:0/18:0-PS+blood 0.559649123 0 0 kegg serum_phospholipids NA 0.377 no no no no no no Propionic acid+stool 16:0/18:0-PS+blood 0 0 0.467669173 yes stool_scfa serum_phospholipids 0.0436 0.377 dn no up no no no Relaxin signaling pathway 16:0/18:0-PS+blood -0.50877193 0 0 kegg serum_phospholipids NA 0.377 no no no no no no Roseburia 16:0/18:0-PS+blood 0 0 0.446153846 butyrate-producing Genus serum_phospholipids 0.495 0.377 no no no no no no Shigellosis 16:0/18:0-PS+blood 0 -0.591176471 0 kegg serum_phospholipids NA 0.377 no no no no no no Th1 and Th2 cell differentiation 16:0/18:0-PS+blood -0.589473684 0 0 kegg serum_phospholipids NA 0.377 no no no no no no Th17 cell differentiation 16:0/18:0-PS+blood -0.636842105 0 0 kegg serum_phospholipids NA 0.377 no no no no no no Ubiquitin mediated proteolysis 16:0/18:0-PS+blood 0 -0.526470588 0 kegg serum_phospholipids NA 0.377 no no no no no no 14:0/18:0-PC+blood 16:0/18:1-PC+blood 0 0 0.550769231 serum_phospholipids serum_phospholipids 0.00289 6.15E-07 up up no up up up 14:0/20:4-PC+blood 16:0/18:1-PC+blood 0 0 -0.418119658 serum_phospholipids serum_phospholipids 0.486 6.15E-07 no no no up up up 16:0/14:0-PC+blood 16:0/18:1-PC+blood 0.664661654 0.644607843 0 serum_phospholipids serum_phospholipids 0.0206 6.15E-07 no up up up up up 16:0/16:0-PC+blood 16:0/18:1-PC+blood 0.581954887 0.708333333 0.425641026 serum_phospholipids serum_phospholipids 0.00079 6.15E-07 no up up up up up 16:0/16:0-PI+blood 16:0/18:1-PC+blood -0.613533835 0 0 serum_phospholipids serum_phospholipids 0.358 6.15E-07 no no no up up up 16:0/16:1-PC+blood 16:0/18:1-PC+blood 0 0 0.525470085 serum_phospholipids serum_phospholipids 0.00283 6.15E-07 up up no up up up 16:0/16:1-PI+blood 16:0/18:1-PC+blood -0.685714286 0 0 serum_phospholipids serum_phospholipids 0.262 6.15E-07 no no no up up up 16:0+blood 16:0/18:1-PC+blood 0 0 0.468717949 yes serum_fattyacid serum_phospholipids 0.00876 6.15E-07 up no no up up up Adherens junction 16:0/18:1-PC+blood 0 0 -0.459230769 kegg serum_phospholipids NA 6.15E-07 no no no up up up Adrenergic signaling in cardiomyocytes 16:0/18:1-PC+blood 0 -0.611764706 0 kegg serum_phospholipids NA 6.15E-07 no no up up up up Alistipes 16:0/18:1-PC+blood 0.529815093 0 0 Genus serum_phospholipids 0.0114 6.15E-07 no up no up up up Allograft rejection 16:0/18:1-PC+blood 0 0.538235294 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up AMPK signaling pathway 16:0/18:1-PC+blood 0 -0.691176471 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up Amyotrophic lateral sclerosis 16:0/18:1-PC+blood 0 0 -0.403846154 kegg serum_phospholipids NA 6.15E-07 no no no up up up Arginine and proline metabolism 16:0/18:1-PC+blood 0 0 0.476153846 kegg serum_phospholipids NA 6.15E-07 no up no up up up Arrhythmogenic right ventricular cardiomyopathy 16:0/18:1-PC+blood 0 0 -0.503076923 kegg serum_phospholipids NA 6.15E-07 no up up up up up Autoimmune thyroid disease 16:0/18:1-PC+blood 0 0.538235294 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up CDCA+stool 16:0/18:1-PC+blood 0 0.609090909 0 stool_bileacids serum_phospholipids 0.663 6.15E-07 no no no up up up Central carbon metabolism in cancer 16:0/18:1-PC+blood 0 -0.644117647 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up Cytokine-cytokine receptor interaction 16:0/18:1-PC+blood 0 0 -0.407692308 kegg serum_phospholipids NA 6.15E-07 no no no up up up Dilated cardiomyopathy 16:0/18:1-PC+blood 0 0 -0.566923077 kegg serum_phospholipids NA 6.15E-07 no up up up up up EGFR tyrosine kinase inhibitor resistance 16:0/18:1-PC+blood 0 0 0.465384615 kegg serum_phospholipids NA 6.15E-07 no no no up up up Epstein-Barr virus infection 16:0/18:1-PC+blood 0 0 0.433846154 kegg serum_phospholipids NA 6.15E-07 no no no up up up Faecalibacterium 16:0/18:1-PC+blood 0 0 -0.404171659 butyrate-producing Genus serum_phospholipids 0.0039 6.15E-07 no dn dn up up up Focal adhesion 16:0/18:1-PC+blood 0 0 -0.466153846 kegg serum_phospholipids NA 6.15E-07 no up up up up up Fusobacterium 16:0/18:1-PC+blood 0 -0.676670116 0 Genus serum_phospholipids 0.628 6.15E-07 no no no up up up Gap junction 16:0/18:1-PC+blood 0 0 -0.44 kegg serum_phospholipids NA 6.15E-07 no no no up up up Gastric acid secretion 16:0/18:1-PC+blood 0 0 -0.508461538 kegg serum_phospholipids NA 6.15E-07 no no no up up up GCA+stool 16:0/18:1-PC+blood 0 0 0.518796992 stool_bileacids serum_phospholipids 0.0809 6.15E-07 no no no up up up GCDCA+stool 16:0/18:1-PC+blood 0 0.627272727 0 yes stool_bileacids serum_phospholipids 0.0471 6.15E-07 no dn no up up up GDCA+stool 16:0/18:1-PC+blood 0 0.646926508 0 stool_bileacids serum_phospholipids 0.656 6.15E-07 no no no up up up "Glycine, serine and threonine metabolism" 16:0/18:1-PC+blood 0 -0.597058824 0 kegg serum_phospholipids NA 6.15E-07 no up no up up up GnRH signaling pathway 16:0/18:1-PC+blood 0 -0.558823529 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up Graft-versus-host disease 16:0/18:1-PC+blood 0 0.538235294 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up HDCA+stool 16:0/18:1-PC+blood 0.653846154 0 0 stool_bileacids serum_phospholipids 0.176 6.15E-07 no no no up up up Hepatocellular carcinoma 16:0/18:1-PC+blood 0 0 -0.503076923 kegg serum_phospholipids NA 6.15E-07 no no no up up up HIF-1 signaling pathway 16:0/18:1-PC+blood 0 0 0.500769231 kegg serum_phospholipids NA 6.15E-07 no no no up up up Hippo signaling pathway 16:0/18:1-PC+blood 0 0 -0.513076923 kegg serum_phospholipids NA 6.15E-07 no no no up up up Human immunodeficiency virus 1 infection 16:0/18:1-PC+blood 0 0 0.433076923 kegg serum_phospholipids NA 6.15E-07 no no no up up up Hypertrophic cardiomyopathy 16:0/18:1-PC+blood 0 0 -0.52 kegg serum_phospholipids NA 6.15E-07 no up up up up up Influenza A 16:0/18:1-PC+blood 0.470175439 0 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up Insulin signaling pathway 16:0/18:1-PC+blood 0 0 0.426153846 kegg serum_phospholipids NA 6.15E-07 no no no up up up LCA+stool 16:0/18:1-PC+blood 0.56043956 0 0 stool_bileacids serum_phospholipids 0.314 6.15E-07 no no no up up up mTOR signaling pathway 16:0/18:1-PC+blood 0 -0.502941176 0.57 kegg serum_phospholipids NA 6.15E-07 no no no up up up p53 signaling pathway 16:0/18:1-PC+blood -0.478947368 0 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up Parabacteroides 16:0/18:1-PC+blood 0.478195489 0 0 Genus serum_phospholipids 4.19E-05 6.15E-07 no up up up up up "Parathyroid hormone synthesis, secretion and action" 16:0/18:1-PC+blood 0 -0.532352941 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up Phenylacetic acid+stool 16:0/18:1-PC+blood 0 -0.636363636 0 stool_cometabolism serum_phospholipids 0.785 6.15E-07 no no no up up up Platelet activation 16:0/18:1-PC+blood 0 0 -0.513846154 kegg serum_phospholipids NA 6.15E-07 no no no up up up Proteasome 16:0/18:1-PC+blood 0 0 0.574615385 kegg serum_phospholipids NA 6.15E-07 no no no up up up Rap1 signaling pathway 16:0/18:1-PC+blood 0 0 -0.500769231 kegg serum_phospholipids NA 6.15E-07 no no no up up up Renal cell carcinoma 16:0/18:1-PC+blood 0 -0.502941176 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up Rheumatoid arthritis 16:0/18:1-PC+blood 0.484210526 0 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up Salmonella infection 16:0/18:1-PC+blood 0 0.570588235 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up TCA+stool 16:0/18:1-PC+blood -0.773040621 0 0.463157895 stool_bileacids serum_phospholipids 0.458 6.15E-07 no no no up up up Th1 and Th2 cell differentiation 16:0/18:1-PC+blood 0 0.544117647 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up Thyroid hormone signaling pathway 16:0/18:1-PC+blood 0 0 -0.529230769 kegg serum_phospholipids NA 6.15E-07 no no no up up up Toxoplasmosis 16:0/18:1-PC+blood 0 0.579411765 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up Type I diabetes mellitus 16:0/18:1-PC+blood 0 0.538235294 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up Vibrio cholerae infection 16:0/18:1-PC+blood 0 0 -0.446153846 kegg serum_phospholipids NA 6.15E-07 no no no up up up Viral myocarditis 16:0/18:1-PC+blood 0 0.561764706 0 kegg serum_phospholipids NA 6.15E-07 no no no up up up 11-HETE+blood 16:0/18:1-PE+blood 0 0.696896142 0 serum_ARA serum_phospholipids 0.464 0.000107 no no no up up no 12-ketoDCA+blood 16:0/18:1-PE+blood 0 -0.592772713 0 serum_bileacids serum_phospholipids 0.517 0.000107 no no no up up no "12,13-EPOME+blood" 16:0/18:1-PE+blood 0 0.48728047 0 serum_ARA serum_phospholipids 0.901 0.000107 no no no up up no 13-HODE+blood 16:0/18:1-PE+blood -0.45112782 0 0 serum_ARA serum_phospholipids 0.32 0.000107 no no no up up no 14:0/18:0-PC+blood 16:0/18:1-PE+blood 0 0.732843137 0 serum_phospholipids serum_phospholipids 0.00289 0.000107 up up no up up no 14:0/20:4-PC+blood 16:0/18:1-PE+blood 0 -0.529411765 0 serum_phospholipids serum_phospholipids 0.486 0.000107 no no no up up no 15-HETE+blood 16:0/18:1-PE+blood -0.527287859 0 0 serum_ARA serum_phospholipids 0.819 0.000107 no no no up up no 16:0-LPE+blood 16:0/18:1-PE+blood 0.603007519 0 0.535726496 serum_phospholipids serum_phospholipids 0.0711 0.000107 up up no up up no 16:0/16:0-PC+blood 16:0/18:1-PE+blood -0.466165414 0 0 serum_phospholipids serum_phospholipids 0.00079 0.000107 no up up up up no 16:0/16:0-PI+blood 16:0/18:1-PE+blood 0.705263158 0.566176471 0 serum_phospholipids serum_phospholipids 0.358 0.000107 no no no up up no 16:0/16:1-PC+blood 16:0/18:1-PE+blood 0 0.732843137 0.405128205 serum_phospholipids serum_phospholipids 0.00283 0.000107 up up no up up no 16:0/16:1-PI+blood 16:0/18:1-PE+blood 0.463157895 0.566176471 0.445470085 serum_phospholipids serum_phospholipids 0.262 0.000107 no no no up up no 16:0/18:0-PC+blood 16:0/18:1-PE+blood 0 0 -0.498803419 serum_phospholipids serum_phospholipids 0.521 0.000107 no no no up up no 16:0/18:0-PS+blood 16:0/18:1-PE+blood 0.569924812 0 0.497435897 serum_phospholipids serum_phospholipids 0.377 0.000107 no no no up up no 16:0/18:1-PC+blood 16:0/18:1-PE+blood -0.566917293 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.000107 up up up up up no 13-HODE+blood 16:0/18:2-PC+blood 0 0.568627451 0 serum_ARA serum_phospholipids 0.32 3.24E-06 no no no no up up 14:0/18:2-PC+blood 16:0/18:2-PC+blood 0 0 -0.446153846 serum_phospholipids serum_phospholipids 0.102 3.24E-06 no up no no up up 14:0/20:4-PC+blood 16:0/18:2-PC+blood 0 0 -0.616410256 serum_phospholipids serum_phospholipids 0.486 3.24E-06 no no no no up up 14:1/18:2-PG+blood 16:0/18:2-PC+blood 0 0 -0.439316239 serum_phospholipids serum_phospholipids 0.00259 3.24E-06 no up up no up up 16:0-LPE+blood 16:0/18:2-PC+blood -0.512781955 0 0 serum_phospholipids serum_phospholipids 0.0711 3.24E-06 up up no no up up 16:0/14:0-PC+blood 16:0/18:2-PC+blood 0.604511278 0.718137255 0.723076923 serum_phospholipids serum_phospholipids 0.0206 3.24E-06 no up up no up up 16:0/16:0-PC+blood 16:0/18:2-PC+blood 0.536842105 0.656862745 0.550769231 serum_phospholipids serum_phospholipids 0.00079 3.24E-06 no up up no up up 16:0/16:0-PI+blood 16:0/18:2-PC+blood -0.521804511 0 0 serum_phospholipids serum_phospholipids 0.358 3.24E-06 no no no no up up 16:0/16:1-PI+blood 16:0/18:2-PC+blood -0.563909774 0 0 serum_phospholipids serum_phospholipids 0.262 3.24E-06 no no no no up up 16:0/18:1-PC+blood 16:0/18:2-PC+blood 0.869172932 0.914215686 0.714188034 serum_phospholipids serum_phospholipids 6.15E-07 3.24E-06 up up up no up up 16:0/18:1-PE+blood 16:0/18:2-PC+blood -0.654135338 0 0 serum_phospholipids serum_phospholipids 0.000107 3.24E-06 up up no no up up Adherens junction 16:0/18:2-PC+blood 0 0 -0.404615385 kegg serum_phospholipids NA 3.24E-06 no no no no up up Adrenergic signaling in cardiomyocytes 16:0/18:2-PC+blood 0 -0.623529412 0 kegg serum_phospholipids NA 3.24E-06 no no up no up up Aldosterone synthesis and secretion 16:0/18:2-PC+blood 0 0 -0.415384615 kegg serum_phospholipids NA 3.24E-06 no up up no up up Alistipes 16:0/18:2-PC+blood 0.458871192 0 0 Genus serum_phospholipids 0.0114 3.24E-06 no up no no up up Alzheimer disease 16:0/18:2-PC+blood 0 0 -0.518461538 kegg serum_phospholipids NA 3.24E-06 no no no no up up AMPK signaling pathway 16:0/18:2-PC+blood 0 -0.638235294 0 kegg serum_phospholipids NA 3.24E-06 no no no no up up Amyotrophic lateral sclerosis 16:0/18:2-PC+blood 0 0 -0.593076923 kegg serum_phospholipids NA 3.24E-06 no no no no up up Blautia 16:0/18:2-PC+blood 0 0 -0.407206513 acetate-producing Genus serum_phospholipids 1.36E-05 3.24E-06 up dn dn no up up Cardiac muscle contraction 16:0/18:2-PC+blood 0 0 -0.556153846 kegg serum_phospholipids NA 3.24E-06 no no up no up up Central carbon metabolism in cancer 16:0/18:2-PC+blood 0 -0.726470588 0 kegg serum_phospholipids NA 3.24E-06 no no no no up up Diabetic cardiomyopathy 16:0/18:2-PC+blood 0 0 -0.510769231 kegg serum_phospholipids NA 3.24E-06 no no no no up up Dilated cardiomyopathy 16:0/18:2-PC+blood 0 0 -0.507692308 kegg serum_phospholipids NA 3.24E-06 no up up no up up EGFR tyrosine kinase inhibitor resistance 16:0/18:2-PC+blood 0 -0.558823529 0 kegg serum_phospholipids NA 3.24E-06 no no no no up up Endocrine and other factor-regulated calcium reabsorption 16:0/18:2-PC+blood 0 0 -0.419230769 kegg serum_phospholipids NA 3.24E-06 no no no no up up Faecalibacterium 16:0/18:2-PC+blood 0 0 -0.408958802 butyrate-producing Genus serum_phospholipids 0.0039 3.24E-06 no dn dn no up up Focal adhesion 16:0/18:2-PC+blood 0 0 -0.424615385 kegg serum_phospholipids NA 3.24E-06 no up up no up up Fusobacterium 16:0/18:2-PC+blood 0 -0.599119159 0 Genus serum_phospholipids 0.628 3.24E-06 no no no no up up Gap junction 16:0/18:2-PC+blood 0 0 -0.481538462 kegg serum_phospholipids NA 3.24E-06 no no no no up up Gastric acid secretion 16:0/18:2-PC+blood 0 0 -0.453076923 kegg serum_phospholipids NA 3.24E-06 no no no no up up GCDCA+stool 16:0/18:2-PC+blood 0 0.609090909 0 yes stool_bileacids serum_phospholipids 0.0471 3.24E-06 no dn no no up up GDCA+stool 16:0/18:2-PC+blood -0.598901099 0 0 stool_bileacids serum_phospholipids 0.656 3.24E-06 no no no no up up "Glycine, serine and threonine metabolism" 16:0/18:2-PC+blood 0 -0.508823529 0 kegg serum_phospholipids NA 3.24E-06 no up no no up up Hepatocellular carcinoma 16:0/18:2-PC+blood 0 0 -0.406153846 kegg serum_phospholipids NA 3.24E-06 no no no no up up Hippo signaling pathway 16:0/18:2-PC+blood 0 0 -0.472307692 kegg serum_phospholipids NA 3.24E-06 no no no no up up Huntington disease 16:0/18:2-PC+blood 0 0 -0.503076923 kegg serum_phospholipids NA 3.24E-06 no no no no up up IL-17 signaling pathway 16:0/18:2-PC+blood 0 0 0.476153846 kegg serum_phospholipids NA 3.24E-06 no no no no up up Inflammatory mediator regulation of TRP channels 16:0/18:2-PC+blood 0 -0.526470588 -0.45 kegg serum_phospholipids NA 3.24E-06 no no no no up up Lachnospira 16:0/18:2-PC+blood 0 0 0.415411568 butyrate-producing Genus serum_phospholipids 0.279 3.24E-06 no no no no up up LCA+stool 16:0/18:2-PC+blood 0.582417582 0 0 stool_bileacids serum_phospholipids 0.314 3.24E-06 no no no no up up mRNA surveillance pathway 16:0/18:2-PC+blood 0 -0.523529412 0 kegg serum_phospholipids NA 3.24E-06 no no no no up up mTOR signaling pathway 16:0/18:2-PC+blood 0 -0.588235294 0.405384615 kegg serum_phospholipids NA 3.24E-06 no no no no up up Non-alcoholic fatty liver disease 16:0/18:2-PC+blood 0 0 -0.596153846 kegg serum_phospholipids NA 3.24E-06 no no no no up up Oxidative phosphorylation 16:0/18:2-PC+blood 0 0 -0.489230769 kegg serum_phospholipids NA 3.24E-06 no no no no up up Pancreatic secretion 16:0/18:2-PC+blood 0 0 -0.474615385 kegg serum_phospholipids NA 3.24E-06 no no no no up up "Parathyroid hormone synthesis, secretion and action" 16:0/18:2-PC+blood 0 -0.520588235 0 kegg serum_phospholipids NA 3.24E-06 no no no no up up Peroxisome 16:0/18:2-PC+blood 0 0 0.421538462 kegg serum_phospholipids NA 3.24E-06 no no no no up up Phenylacetic acid+stool 16:0/18:2-PC+blood 0 -0.627272727 0 stool_cometabolism serum_phospholipids 0.785 3.24E-06 no no no no up up Platelet activation 16:0/18:2-PC+blood 0 0 -0.427692308 kegg serum_phospholipids NA 3.24E-06 no no no no up up Prion disease 16:0/18:2-PC+blood 0 0 -0.51 kegg serum_phospholipids NA 3.24E-06 no no no no up up Proteasome 16:0/18:2-PC+blood 0 0 0.544615385 kegg serum_phospholipids NA 3.24E-06 no no no no up up Renal cell carcinoma 16:0/18:2-PC+blood 0 -0.5 0 kegg serum_phospholipids NA 3.24E-06 no no no no up up Retrograde endocannabinoid signaling 16:0/18:2-PC+blood 0 0 -0.411538462 kegg serum_phospholipids NA 3.24E-06 no no up no up up RNA transport 16:0/18:2-PC+blood 0 -0.564705882 0 kegg serum_phospholipids NA 3.24E-06 no no no no up up Ruminococcus 16:0/18:2-PC+blood 0 0 -0.422411323 Genus serum_phospholipids 0.0679 3.24E-06 no no dn no up up Salmonella infection 16:0/18:2-PC+blood 0 0.505882353 0 kegg serum_phospholipids NA 3.24E-06 no no no no up up TCA+stool 16:0/18:2-PC+blood -0.629986841 0 0 stool_bileacids serum_phospholipids 0.458 3.24E-06 no no no no up up Th1 and Th2 cell differentiation 16:0/18:2-PC+blood 0 0.532352941 0 kegg serum_phospholipids NA 3.24E-06 no no no no up up Thermogenesis 16:0/18:2-PC+blood 0 0 -0.429230769 kegg serum_phospholipids NA 3.24E-06 no no no no up up Thyroid hormone signaling pathway 16:0/18:2-PC+blood 0 0 -0.527692308 kegg serum_phospholipids NA 3.24E-06 no no no no up up Toxoplasmosis 16:0/18:2-PC+blood 0 0.561764706 0 kegg serum_phospholipids NA 3.24E-06 no no no no up up UDCA+stool 16:0/18:2-PC+blood 0 0 -0.445112782 stool_bileacids serum_phospholipids 0.266 3.24E-06 no no no no up up Vasopressin-regulated water reabsorption 16:0/18:2-PC+blood 0 0 -0.471538462 kegg serum_phospholipids NA 3.24E-06 no no no no up up Viral myocarditis 16:0/18:2-PC+blood 0 0.5 0 kegg serum_phospholipids NA 3.24E-06 no no no no up up 11-HETE+blood 16:0/18:2-PI+blood -0.510881788 0 0 serum_ARA serum_phospholipids 0.464 0.269 no no no no no no "12,13-EPOME+blood" 16:0/18:2-PI+blood 0 0.496049013 0 serum_ARA serum_phospholipids 0.901 0.269 no no no no no no 14:0-LPC+blood 16:0/18:2-PI+blood 0.672180451 0.482843137 0.66017094 serum_phospholipids serum_phospholipids 0.00689 0.269 up up no no no no 14:0/16:0-PC+blood 16:0/18:2-PI+blood 0 0 0.623931624 serum_phospholipids serum_phospholipids 0.0358 0.269 no up no no no no 14:0/18:0-PC+blood 16:0/18:2-PI+blood 0 0.740196078 0.598632479 serum_phospholipids serum_phospholipids 0.00289 0.269 up up no no no no 14:0/18:2-PC+blood 16:0/18:2-PI+blood 0.523308271 0 0.483076923 serum_phospholipids serum_phospholipids 0.102 0.269 no up no no no no 14:0+blood 16:0/18:2-PI+blood 0.518796992 0 0.424957265 yes serum_fattyacid serum_phospholipids 0.00572 0.269 up no dn no no no 14:1/18:2-PG+blood 16:0/18:2-PI+blood 0.479699248 0 0.574700855 serum_phospholipids serum_phospholipids 0.00259 0.269 no up up no no no 16:0-LPC+blood 16:0/18:2-PI+blood 0 0 0.474871795 serum_phospholipids serum_phospholipids 0.00456 0.269 up up no no no no 16:0/16:0-PI+blood 16:0/18:2-PI+blood 0.830075188 0.681372549 0.794188034 serum_phospholipids serum_phospholipids 0.358 0.269 no no no no no no 16:0/16:1-PC+blood 16:0/18:2-PI+blood 0 0.723039216 0.624615385 serum_phospholipids serum_phospholipids 0.00283 0.269 up up no no no no 16:0/16:1-PI+blood 16:0/18:2-PI+blood 0.726315789 0.634803922 0.825641026 serum_phospholipids serum_phospholipids 0.262 0.269 no no no no no no 16:0/18:1-PC+blood 16:0/18:2-PI+blood -0.684210526 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.269 up up up no no no 16:0/18:1-PE+blood 16:0/18:2-PI+blood 0.515789474 0.740196078 0 serum_phospholipids serum_phospholipids 0.000107 0.269 up up no no no no 16:0+blood 16:0/18:2-PI+blood 0 0 0.407863248 yes serum_fattyacid serum_phospholipids 0.00876 0.269 up no no no no no Acetic acid+stool 16:0/18:2-PI+blood 0.56043956 0 0 yes stool_scfa serum_phospholipids 0.0656 0.269 dn no no no no no Adipocytokine signaling pathway 16:0/18:2-PI+blood -0.503508772 0 0.554615385 kegg serum_phospholipids NA 0.269 no no no no no no Alcoholism 16:0/18:2-PI+blood 0 0 0.423846154 kegg serum_phospholipids NA 0.269 no no no no no no Aldosterone synthesis and secretion 16:0/18:2-PI+blood 0 0 0.406923077 kegg serum_phospholipids NA 0.269 no up up no no no Alistipes 16:0/18:2-PI+blood -0.457361747 0 0 Genus serum_phospholipids 0.0114 0.269 no up no no no no Amphetamine addiction 16:0/18:2-PI+blood 0 0 0.412307692 kegg serum_phospholipids NA 0.269 no no no no no no Axon guidance 16:0/18:2-PI+blood 0 0.679411765 0 kegg serum_phospholipids NA 0.269 no up up no no no B cell receptor signaling pathway 16:0/18:2-PI+blood -0.464912281 0 0.415384615 kegg serum_phospholipids NA 0.269 no no no no no no Bacterial invasion of epithelial cells 16:0/18:2-PI+blood 0 0 -0.436923077 kegg serum_phospholipids NA 0.269 no no no no no no Biosynthesis of cofactors 16:0/18:2-PI+blood 0 0 0.450769231 kegg serum_phospholipids NA 0.269 no no no no no no C-type lectin receptor signaling pathway 16:0/18:2-PI+blood 0 0 0.400769231 kegg serum_phospholipids NA 0.269 no no no no no no Calcium signaling pathway 16:0/18:2-PI+blood 0 0 0.456923077 kegg serum_phospholipids NA 0.269 no up up no no no cAMP signaling pathway 16:0/18:2-PI+blood 0 0 0.64 yes kegg serum_phospholipids NA 0.269 no up up no no no Carbon metabolism 16:0/18:2-PI+blood 0 0 -0.592307692 kegg serum_phospholipids NA 0.269 no no no no no no Chagas disease 16:0/18:2-PI+blood 0 0 0.405384615 kegg serum_phospholipids NA 0.269 no no no no no no Chemokine signaling pathway 16:0/18:2-PI+blood -0.471929825 0 0 kegg serum_phospholipids NA 0.269 no no no no no no Chronic myeloid leukemia 16:0/18:2-PI+blood 0 0 0.489230769 kegg serum_phospholipids NA 0.269 no no no no no no Cocaine addiction 16:0/18:2-PI+blood 0 0 0.694615385 kegg serum_phospholipids NA 0.269 no no no no no no Cortisol synthesis and secretion 16:0/18:2-PI+blood 0 0 0.642307692 kegg serum_phospholipids NA 0.269 no no up no no no Cushing syndrome 16:0/18:2-PI+blood 0 0 0.481538462 kegg serum_phospholipids NA 0.269 no no up no no no Cytosolic DNA-sensing pathway 16:0/18:2-PI+blood 0 0 0.546923077 kegg serum_phospholipids NA 0.269 no no no no no no Endocrine and other factor-regulated calcium reabsorption 16:0/18:2-PI+blood 0 0 0.404615385 kegg serum_phospholipids NA 0.269 no no no no no no Fc gamma R-mediated phagocytosis 16:0/18:2-PI+blood 0 0 -0.466923077 kegg serum_phospholipids NA 0.269 no no no no no no Ferroptosis 16:0/18:2-PI+blood 0 0 0.41 kegg serum_phospholipids NA 0.269 no no no no no no FoxO signaling pathway 16:0/18:2-PI+blood 0 -0.555882353 -0.413846154 kegg serum_phospholipids NA 0.269 no no no no no no "Glycine, serine and threonine metabolism" 16:0/18:2-PI+blood 0 0 0.493076923 kegg serum_phospholipids NA 0.269 no up no no no no Glycolysis / Gluconeogenesis 16:0/18:2-PI+blood 0 0 -0.579230769 kegg serum_phospholipids NA 0.269 no no no no no no GnRH signaling pathway 16:0/18:2-PI+blood 0 0 0.406923077 kegg serum_phospholipids NA 0.269 no no no no no no "Growth hormone synthesis, secretion and action" 16:0/18:2-PI+blood 0 0 0.451538462 kegg serum_phospholipids NA 0.269 no no no no no no Hepatitis B 16:0/18:2-PI+blood 0 0 0.415384615 kegg serum_phospholipids NA 0.269 no no no no no no Hepatitis C 16:0/18:2-PI+blood 0 0 0.544615385 kegg serum_phospholipids NA 0.269 no no no no no no Influenza A 16:0/18:2-PI+blood -0.496491228 0 0 kegg serum_phospholipids NA 0.269 no no no no no no Insulin secretion 16:0/18:2-PI+blood 0 0 0.559230769 yes kegg serum_phospholipids NA 0.269 no up up no no no Kaposi sarcoma-associated herpesvirus infection 16:0/18:2-PI+blood 0 0 0.549230769 kegg serum_phospholipids NA 0.269 no no dn no no no Legionellosis 16:0/18:2-PI+blood 0.507017544 0 0 kegg serum_phospholipids NA 0.269 no no no no no no Leukocyte transendothelial migration 16:0/18:2-PI+blood 0 0.564705882 0 kegg serum_phospholipids NA 0.269 no no no no no no Long-term depression 16:0/18:2-PI+blood 0 0 0.533846154 kegg serum_phospholipids NA 0.269 no no no no no no Longevity regulating pathway - multiple species 16:0/18:2-PI+blood 0.515789474 0 -0.483846154 kegg serum_phospholipids NA 0.269 no no no no no no Malaria 16:0/18:2-PI+blood 0 0 0.442307692 kegg serum_phospholipids NA 0.269 no no no no no no MAPK signaling pathway 16:0/18:2-PI+blood 0 -0.697058824 0 kegg serum_phospholipids NA 0.269 no no no no no no Measles 16:0/18:2-PI+blood 0 -0.529411765 0 kegg serum_phospholipids NA 0.269 no no no no no no Mitophagy - animal 16:0/18:2-PI+blood 0 0 0.427692308 kegg serum_phospholipids NA 0.269 no no no no no no Morphine addiction 16:0/18:2-PI+blood 0 0 0.489230769 kegg serum_phospholipids NA 0.269 no up up no no no Neuroactive ligand-receptor interaction 16:0/18:2-PI+blood 0 0 -0.437692308 kegg serum_phospholipids NA 0.269 up up up no no no Neurotrophin signaling pathway 16:0/18:2-PI+blood 0 0 0.402307692 kegg serum_phospholipids NA 0.269 no no no no no no NF-kappa B signaling pathway 16:0/18:2-PI+blood 0 0 0.427692308 kegg serum_phospholipids NA 0.269 no no no no no no Non-alcoholic fatty liver disease 16:0/18:2-PI+blood 0 0 0.401538462 kegg serum_phospholipids NA 0.269 no no no no no no p53 signaling pathway 16:0/18:2-PI+blood 0 -0.502941176 0 kegg serum_phospholipids NA 0.269 no no no no no no Parabacteroides 16:0/18:2-PI+blood 0 -0.485294118 0 Genus serum_phospholipids 4.19E-05 0.269 no up up no no no Parkinson disease 16:0/18:2-PI+blood 0 0 0.508461538 kegg serum_phospholipids NA 0.269 no no no no no no Pathways of neurodegeneration - multiple diseases 16:0/18:2-PI+blood 0 0 0.503846154 kegg serum_phospholipids NA 0.269 no no no no no no Phenylacetic acid+stool 16:0/18:2-PI+blood -0.818681319 0 0 stool_cometabolism serum_phospholipids 0.785 0.269 no no no no no no PI3K-Akt signaling pathway 16:0/18:2-PI+blood 0.524561404 0 0 yes kegg serum_phospholipids NA 0.269 no up up no no no Porphyrin and chlorophyll metabolism 16:0/18:2-PI+blood 0 0 0.466153846 kegg serum_phospholipids NA 0.269 no no no no no no Primary immunodeficiency 16:0/18:2-PI+blood 0.680701754 0 -0.545384615 kegg serum_phospholipids NA 0.269 no no no no no no Progesterone-mediated oocyte maturation 16:0/18:2-PI+blood 0 0 -0.407692308 kegg serum_phospholipids NA 0.269 no no no no no no Propionic acid+stool 16:0/18:2-PI+blood 0.604395604 0 0 yes stool_scfa serum_phospholipids 0.0436 0.269 dn no up no no no Prostate cancer 16:0/18:2-PI+blood 0 0 0.54 kegg serum_phospholipids NA 0.269 no no no no no no Purine metabolism 16:0/18:2-PI+blood 0 0 0.412307692 kegg serum_phospholipids NA 0.269 no no no no no no Relaxin signaling pathway 16:0/18:2-PI+blood 0 0 0.636153846 kegg serum_phospholipids NA 0.269 no no no no no no Rheumatoid arthritis 16:0/18:2-PI+blood 0 0 -0.466923077 kegg serum_phospholipids NA 0.269 no no no no no no Ribosome biogenesis in eukaryotes 16:0/18:2-PI+blood 0.464912281 0 0 kegg serum_phospholipids NA 0.269 no no no no no no RIG-I-like receptor signaling pathway 16:0/18:2-PI+blood 0 0 0.556153846 kegg serum_phospholipids NA 0.269 no no no no no no RNA transport 16:0/18:2-PI+blood 0.503508772 0 0 kegg serum_phospholipids NA 0.269 no no no no no no Roseburia 16:0/18:2-PI+blood 0 0.539546392 0 butyrate-producing Genus serum_phospholipids 0.495 0.269 no no no no no no Ruminococcus 16:0/18:2-PI+blood 0 0.67443299 0.450546731 Genus serum_phospholipids 0.0679 0.269 no no dn no no no Salmonella infection 16:0/18:2-PI+blood 0 0 -0.421538462 kegg serum_phospholipids NA 0.269 no no no no no no Small cell lung cancer 16:0/18:2-PI+blood 0 0 0.612307692 kegg serum_phospholipids NA 0.269 no no up no no no Sphingolipid signaling pathway 16:0/18:2-PI+blood 0 0 -0.528461538 kegg serum_phospholipids NA 0.269 no no no no no no Spliceosome 16:0/18:2-PI+blood 0 -0.511764706 0 kegg serum_phospholipids NA 0.269 no no no no no no TCA+stool 16:0/18:2-PI+blood 0 0.663636364 0 stool_bileacids serum_phospholipids 0.458 0.269 no no no no no no Th1 and Th2 cell differentiation 16:0/18:2-PI+blood -0.596491228 0 0 kegg serum_phospholipids NA 0.269 no no no no no no Th17 cell differentiation 16:0/18:2-PI+blood -0.468421053 0 0 kegg serum_phospholipids NA 0.269 no no no no no no Thyroid hormone synthesis 16:0/18:2-PI+blood 0 0 0.450769231 kegg serum_phospholipids NA 0.269 no no no no no no Tight junction 16:0/18:2-PI+blood 0 0.570588235 0 kegg serum_phospholipids NA 0.269 no no no no no no TNF signaling pathway 16:0/18:2-PI+blood 0 0 0.429230769 kegg serum_phospholipids NA 0.269 no no no no no no total_stool_scfa+stool 16:0/18:2-PI+blood 0.598901099 0 0 stool_scfa serum_phospholipids 0.0534 0.269 dn no up no no no Transcriptional misregulation in cancer 16:0/18:2-PI+blood 0 0 0.426923077 kegg serum_phospholipids NA 0.269 no no no no no no Tuberculosis 16:0/18:2-PI+blood 0 0 -0.506153846 kegg serum_phospholipids NA 0.269 no no dn no no no Ubiquitin mediated proteolysis 16:0/18:2-PI+blood 0 0 0.412307692 kegg serum_phospholipids NA 0.269 no no no no no no 12-HEPE+blood 16:0/18:3-PC+blood -0.50071772 0 0 serum_ARA serum_phospholipids 0.312 0.00216 no no no no up up 14:0-LPC+blood 16:0/18:3-PC+blood 0 0 0.596581197 serum_phospholipids serum_phospholipids 0.00689 0.00216 up up no no up up 14:0/16:0-PC+blood 16:0/18:3-PC+blood 0 0 0.751794872 serum_phospholipids serum_phospholipids 0.0358 0.00216 no up no no up up 14:0/18:0-PC+blood 16:0/18:3-PC+blood 0 0 0.781880342 serum_phospholipids serum_phospholipids 0.00289 0.00216 up up no no up up 14:0/18:2-PC+blood 16:0/18:3-PC+blood 0.542857143 0.602941176 0.567179487 serum_phospholipids serum_phospholipids 0.102 0.00216 no up no no up up 14:0/20:4-PC+blood 16:0/18:3-PC+blood 0.6 0.590686275 0.457094017 serum_phospholipids serum_phospholipids 0.486 0.00216 no no no no up up 14:0+blood 16:0/18:3-PC+blood 0 0 0.513846154 yes serum_fattyacid serum_phospholipids 0.00572 0.00216 up no dn no up up 14:1/18:2-PG+blood 16:0/18:3-PC+blood 0 0 0.466666667 serum_phospholipids serum_phospholipids 0.00259 0.00216 no up up no up up 16:0/16:0-PI+blood 16:0/18:3-PC+blood 0 0 0.515897436 serum_phospholipids serum_phospholipids 0.358 0.00216 no no no no up up 16:0/16:1-PC+blood 16:0/18:3-PC+blood 0 0 0.786666667 serum_phospholipids serum_phospholipids 0.00283 0.00216 up up no no up up 16:0/16:1-PI+blood 16:0/18:3-PC+blood 0 0 0.614358974 serum_phospholipids serum_phospholipids 0.262 0.00216 no no no no up up 16:0/18:0-PC+blood 16:0/18:3-PC+blood 0 0.578431373 0 serum_phospholipids serum_phospholipids 0.521 0.00216 no no no no up up 16:0/18:2-PI+blood 16:0/18:3-PC+blood 0 0 0.557606838 serum_phospholipids serum_phospholipids 0.269 0.00216 no no no no up up 16:0+blood 16:0/18:3-PC+blood 0 0 0.417435897 yes serum_fattyacid serum_phospholipids 0.00876 0.00216 up no no no up up Amoebiasis 16:0/18:3-PC+blood 0 0 -0.42 kegg serum_phospholipids NA 0.00216 no no no no up up Amphetamine addiction 16:0/18:3-PC+blood -0.549122807 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Antigen processing and presentation 16:0/18:3-PC+blood 0.624561404 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Biosynthesis of amino acids 16:0/18:3-PC+blood 0.535087719 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Blautia 16:0/18:3-PC+blood 0 -0.578431373 0 acetate-producing Genus serum_phospholipids 1.36E-05 0.00216 up dn dn no up up CA+stool 16:0/18:3-PC+blood 0.769230769 0 0 stool_bileacids serum_phospholipids 0.827 0.00216 no no no no up up Carbon metabolism 16:0/18:3-PC+blood 0.559649123 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up CDCA+stool 16:0/18:3-PC+blood 0.840659341 0 0 stool_bileacids serum_phospholipids 0.663 0.00216 no no no no up up Cell adhesion molecules 16:0/18:3-PC+blood 0.463157895 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Cellular senescence 16:0/18:3-PC+blood 0.48245614 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Chemical carcinogenesis - receptor activation 16:0/18:3-PC+blood -0.628070175 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Coprococcus 16:0/18:3-PC+blood 0 0 -0.426324786 butyrate-producing Genus serum_phospholipids 0.612 0.00216 no no no no up up Cushing syndrome 16:0/18:3-PC+blood -0.571929825 0 0 kegg serum_phospholipids NA 0.00216 no no up no up up Dorea 16:0/18:3-PC+blood 0.466165414 0 0 Genus serum_phospholipids 0.00362 0.00216 up no dn no up up Endocrine resistance 16:0/18:3-PC+blood -0.561403509 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Epstein-Barr virus infection 16:0/18:3-PC+blood 0.571929825 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Fc gamma R-mediated phagocytosis 16:0/18:3-PC+blood 0 0 -0.521538462 kegg serum_phospholipids NA 0.00216 no no no no up up GCA+stool 16:0/18:3-PC+blood 0 0 0.476691729 stool_bileacids serum_phospholipids 0.0809 0.00216 no no no no up up Glucagon signaling pathway 16:0/18:3-PC+blood -0.463157895 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up "Growth hormone synthesis, secretion and action" 16:0/18:3-PC+blood -0.457894737 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up HCA+stool 16:0/18:3-PC+blood 0.785714286 0 0 stool_bileacids serum_phospholipids 0.155 0.00216 no no no no up up HDCA+stool 16:0/18:3-PC+blood -0.67032967 0 0 stool_bileacids serum_phospholipids 0.176 0.00216 no no no no up up Herpes simplex virus 1 infection 16:0/18:3-PC+blood 0.573684211 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Human cytomegalovirus infection 16:0/18:3-PC+blood 0.542105263 0 0 kegg serum_phospholipids NA 0.00216 no no dn no up up Human immunodeficiency virus 1 infection 16:0/18:3-PC+blood 0.550877193 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Human T-cell leukemia virus 1 infection 16:0/18:3-PC+blood 0.621052632 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up iso-LCA+stool 16:0/18:3-PC+blood -0.762036484 0 0 stool_bileacids serum_phospholipids 0.72 0.00216 no no no no up up Leishmaniasis 16:0/18:3-PC+blood 0.563157895 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Long-term depression 16:0/18:3-PC+blood -0.477192982 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Longevity regulating pathway 16:0/18:3-PC+blood -0.501754386 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Mineral absorption 16:0/18:3-PC+blood -0.571929825 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Natural killer cell mediated cytotoxicity 16:0/18:3-PC+blood 0.50877193 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Necroptosis 16:0/18:3-PC+blood -0.540350877 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Neuroactive ligand-receptor interaction 16:0/18:3-PC+blood 0 0 -0.536923077 kegg serum_phospholipids NA 0.00216 up up up no up up Non-alcoholic fatty liver disease 16:0/18:3-PC+blood -0.471929825 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up nutriCA+stool 16:0/18:3-PC+blood 0.93956044 0 0 stool_bileacids serum_phospholipids 0.481 0.00216 no no no no up up "Parathyroid hormone synthesis, secretion and action" 16:0/18:3-PC+blood -0.557894737 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Parkinson disease 16:0/18:3-PC+blood -0.464912281 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Pathways of neurodegeneration - multiple diseases 16:0/18:3-PC+blood -0.459649123 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Pertussis 16:0/18:3-PC+blood 0.607017544 0 0 kegg serum_phospholipids NA 0.00216 no no dn no up up Rheumatoid arthritis 16:0/18:3-PC+blood 0.463157895 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up Ruminococcus 16:0/18:3-PC+blood 0.625775533 0 0 Genus serum_phospholipids 0.0679 0.00216 no no dn no up up Thermogenesis 16:0/18:3-PC+blood -0.492982456 0 0 kegg serum_phospholipids NA 0.00216 no no no no up up UDCA+stool 16:0/18:3-PC+blood 0.879120879 0 0 stool_bileacids serum_phospholipids 0.266 0.00216 no no no no up up "12,13-EPOME+blood" 16:0/20:3-PC+blood 0 0 -0.467504408 serum_ARA serum_phospholipids 0.901 5.43E-06 no no no no up up 14:0/18:0-PC+blood 16:0/20:3-PC+blood 0 0.49754902 0 serum_phospholipids serum_phospholipids 0.00289 5.43E-06 up up no no up up 16:0-LPC+blood 16:0/20:3-PC+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 0.00456 5.43E-06 up up no no up up 16:0-LPE+blood 16:0/20:3-PC+blood -0.818045113 0 0 serum_phospholipids serum_phospholipids 0.0711 5.43E-06 up up no no up up 16:0/14:0-PC+blood 16:0/20:3-PC+blood 0.517293233 0.705882353 0 serum_phospholipids serum_phospholipids 0.0206 5.43E-06 no up up no up up 16:0/16:0-PI+blood 16:0/20:3-PC+blood -0.616541353 0 0 serum_phospholipids serum_phospholipids 0.358 5.43E-06 no no no no up up 16:0/16:1-PC+blood 16:0/20:3-PC+blood 0 0.504901961 0 serum_phospholipids serum_phospholipids 0.00283 5.43E-06 up up no no up up 16:0/16:1-PI+blood 16:0/20:3-PC+blood -0.604511278 0 0 serum_phospholipids serum_phospholipids 0.262 5.43E-06 no no no no up up 16:0/18:1-PC+blood 16:0/20:3-PC+blood 0.571428571 0.610294118 0.568547009 serum_phospholipids serum_phospholipids 6.15E-07 5.43E-06 up up up no up up 16:0/18:1-PE+blood 16:0/20:3-PC+blood -0.590977444 0 0 serum_phospholipids serum_phospholipids 0.000107 5.43E-06 up up no no up up 16:0/18:2-PC+blood 16:0/20:3-PC+blood 0.717293233 0.556372549 0.461196581 serum_phospholipids serum_phospholipids 3.24E-06 5.43E-06 no up up no up up Adipocytokine signaling pathway 16:0/20:3-PC+blood 0 0 0.431538462 kegg serum_phospholipids NA 5.43E-06 no no no no up up Antigen processing and presentation 16:0/20:3-PC+blood 0 0.614705882 0 kegg serum_phospholipids NA 5.43E-06 no no no no up up Butyricimonas 16:0/20:3-PC+blood 0.604099881 0 0 butyrate-producing Genus serum_phospholipids 0.17 5.43E-06 no no no no up up CA+stool 16:0/20:3-PC+blood 0 0.718181818 0 stool_bileacids serum_phospholipids 0.827 5.43E-06 no no no no up up Calcium signaling pathway 16:0/20:3-PC+blood 0.529824561 0 0 kegg serum_phospholipids NA 5.43E-06 no up up no up up CDCA+stool 16:0/20:3-PC+blood 0 0.781818182 0 stool_bileacids serum_phospholipids 0.663 5.43E-06 no no no no up up Chemical carcinogenesis - receptor activation 16:0/20:3-PC+blood 0 -0.5 0 kegg serum_phospholipids NA 5.43E-06 no no no no up up Colorectal cancer 16:0/20:3-PC+blood 0 0 -0.423076923 kegg serum_phospholipids NA 5.43E-06 no no no no up up DCA+stool 16:0/20:3-PC+blood 0 0 -0.463157895 stool_bileacids serum_phospholipids 0.195 5.43E-06 no no no no up up Epstein-Barr virus infection 16:0/20:3-PC+blood 0 0.664705882 0 kegg serum_phospholipids NA 5.43E-06 no no no no up up Ferroptosis 16:0/20:3-PC+blood 0 0 0.580769231 kegg serum_phospholipids NA 5.43E-06 no no no no up up Focal adhesion 16:0/20:3-PC+blood 0 0 -0.424615385 kegg serum_phospholipids NA 5.43E-06 no up up no up up FoxO signaling pathway 16:0/20:3-PC+blood 0 0 -0.458461538 kegg serum_phospholipids NA 5.43E-06 no no no no up up Fusobacterium 16:0/20:3-PC+blood 0 -0.513965167 0.462106259 Genus serum_phospholipids 0.628 5.43E-06 no no no no up up Gastric cancer 16:0/20:3-PC+blood 0 0 -0.444615385 kegg serum_phospholipids NA 5.43E-06 no no no no up up GCDCA+stool 16:0/20:3-PC+blood 0 0.8 0 yes stool_bileacids serum_phospholipids 0.0471 5.43E-06 no dn no no up up GDCA+stool 16:0/20:3-PC+blood 0 0.751710379 0 stool_bileacids serum_phospholipids 0.656 5.43E-06 no no no no up up HDCA+stool 16:0/20:3-PC+blood 0 0 -0.523308271 stool_bileacids serum_phospholipids 0.176 5.43E-06 no no no no up up Hepatocellular carcinoma 16:0/20:3-PC+blood 0 0 -0.406153846 kegg serum_phospholipids NA 5.43E-06 no no no no up up Herpes simplex virus 1 infection 16:0/20:3-PC+blood 0 0.620588235 0 kegg serum_phospholipids NA 5.43E-06 no no no no up up Hippo signaling pathway 16:0/20:3-PC+blood 0 0 -0.428461538 kegg serum_phospholipids NA 5.43E-06 no no no no up up Human cytomegalovirus infection 16:0/20:3-PC+blood 0 0.608823529 0 kegg serum_phospholipids NA 5.43E-06 no no dn no up up Human immunodeficiency virus 1 infection 16:0/20:3-PC+blood 0 0.638235294 0 kegg serum_phospholipids NA 5.43E-06 no no no no up up Human T-cell leukemia virus 1 infection 16:0/20:3-PC+blood 0 0.611764706 0 kegg serum_phospholipids NA 5.43E-06 no no no no up up Intestinal immune network for IgA production 16:0/20:3-PC+blood 0.626315789 0 0 kegg serum_phospholipids NA 5.43E-06 no no no no up up Kaposi sarcoma-associated herpesvirus infection 16:0/20:3-PC+blood 0 0 0.507692308 kegg serum_phospholipids NA 5.43E-06 no no dn no up up L-Phenylalanine+stool 16:0/20:3-PC+blood 0 -0.7 0 stool_cometabolism serum_phospholipids 0.398 5.43E-06 no no no no up up Lachnospira 16:0/20:3-PC+blood 0 0 0.472603433 butyrate-producing Genus serum_phospholipids 0.279 5.43E-06 no no no no up up Malaria 16:0/20:3-PC+blood 0 0 0.492307692 kegg serum_phospholipids NA 5.43E-06 no no no no up up Mineral absorption 16:0/20:3-PC+blood 0 0 0.511538462 kegg serum_phospholipids NA 5.43E-06 no no no no up up Mitophagy - animal 16:0/20:3-PC+blood 0 0 0.440769231 kegg serum_phospholipids NA 5.43E-06 no no no no up up Necroptosis 16:0/20:3-PC+blood 0 0 0.496923077 kegg serum_phospholipids NA 5.43E-06 no no no no up up nutriCA+stool 16:0/20:3-PC+blood 0 0.651403561 0 stool_bileacids serum_phospholipids 0.481 5.43E-06 no no no no up up Oocyte meiosis 16:0/20:3-PC+blood 0 0 -0.404615385 kegg serum_phospholipids NA 5.43E-06 no no no no up up Phenylacetic acid+stool 16:0/20:3-PC+blood 0 -0.845454545 0 stool_cometabolism serum_phospholipids 0.785 5.43E-06 no no no no up up Phosphatidylinositol signaling system 16:0/20:3-PC+blood 0 0 -0.474615385 kegg serum_phospholipids NA 5.43E-06 no no no no up up Porphyrin and chlorophyll metabolism 16:0/20:3-PC+blood 0 0 0.403076923 kegg serum_phospholipids NA 5.43E-06 no no no no up up Prevotella 16:0/20:3-PC+blood -0.544827422 0 0 acetate-producing Genus serum_phospholipids 0.287 5.43E-06 no no no no up up Progesterone-mediated oocyte maturation 16:0/20:3-PC+blood 0 0 -0.401538462 kegg serum_phospholipids NA 5.43E-06 no no no no up up Purine metabolism 16:0/20:3-PC+blood 0 0 0.436153846 kegg serum_phospholipids NA 5.43E-06 no no no no up up Shigellosis 16:0/20:3-PC+blood 0 0 0.42 kegg serum_phospholipids NA 5.43E-06 no no no no up up Signaling pathways regulating pluripotency of stem cells 16:0/20:3-PC+blood 0 0 -0.407692308 kegg serum_phospholipids NA 5.43E-06 no no no no up up Sphingolipid signaling pathway 16:0/20:3-PC+blood 0 0 -0.435384615 kegg serum_phospholipids NA 5.43E-06 no no no no up up TCA+stool 16:0/20:3-PC+blood 0 0 0.505263158 stool_bileacids serum_phospholipids 0.458 5.43E-06 no no no no up up Th1 and Th2 cell differentiation 16:0/20:3-PC+blood 0.459649123 0 0 kegg serum_phospholipids NA 5.43E-06 no no no no up up Th17 cell differentiation 16:0/20:3-PC+blood 0.456140351 0 0 kegg serum_phospholipids NA 5.43E-06 no no no no up up Thyroid hormone signaling pathway 16:0/20:3-PC+blood 0 0 -0.49 kegg serum_phospholipids NA 5.43E-06 no no no no up up Ubiquitin mediated proteolysis 16:0/20:3-PC+blood 0 0 0.43 kegg serum_phospholipids NA 5.43E-06 no no no no up up UDCA+stool 16:0/20:3-PC+blood 0 0.663636364 0 stool_bileacids serum_phospholipids 0.266 5.43E-06 no no no no up up Viral protein interaction with cytokine and cytokine receptor 16:0/20:3-PC+blood 0.459649123 0 0 kegg serum_phospholipids NA 5.43E-06 no no no no up up 14:0/18:0-PC+blood 16:0/20:4-PC+blood 0 -0.524509804 0 serum_phospholipids serum_phospholipids 0.00289 0.0262 up up no no up no 16:0-LPC+blood 16:0/20:4-PC+blood 0 0 -0.515897436 serum_phospholipids serum_phospholipids 0.00456 0.0262 up up no no up no 16:0-LPE+blood 16:0/20:4-PC+blood -0.551879699 0 0 serum_phospholipids serum_phospholipids 0.0711 0.0262 up up no no up no 16:0/14:0-PC+blood 16:0/20:4-PC+blood 0.65112782 0 0.59042735 serum_phospholipids serum_phospholipids 0.0206 0.0262 no up up no up no 16:0/16:0-PC+blood 16:0/20:4-PC+blood 0 0 0.433162393 serum_phospholipids serum_phospholipids 0.00079 0.0262 no up up no up no 16:0/16:0-PI+blood 16:0/20:4-PC+blood -0.596992481 -0.666666667 0 serum_phospholipids serum_phospholipids 0.358 0.0262 no no no no up no 16:0/16:1-PC+blood 16:0/20:4-PC+blood 0 -0.529411765 0 serum_phospholipids serum_phospholipids 0.00283 0.0262 up up no no up no 16:0/16:1-PI+blood 16:0/20:4-PC+blood -0.64962406 -0.62254902 0 serum_phospholipids serum_phospholipids 0.262 0.0262 no no no no up no 16:0/18:1-PC+blood 16:0/20:4-PC+blood 0.741353383 0.556372549 0 serum_phospholipids serum_phospholipids 6.15E-07 0.0262 up up up no up no 16:0/18:1-PE+blood 16:0/20:4-PC+blood -0.606015038 -0.56127451 0 serum_phospholipids serum_phospholipids 0.000107 0.0262 up up no no up no 16:0/18:2-PC+blood 16:0/20:4-PC+blood 0.654135338 0.49754902 0.554188034 serum_phospholipids serum_phospholipids 3.24E-06 0.0262 no up up no up no 16:0/18:2-PI+blood 16:0/20:4-PC+blood -0.590977444 -0.767156863 0 serum_phospholipids serum_phospholipids 0.269 0.0262 no no no no up no 16:0/20:3-PC+blood 16:0/20:4-PC+blood 0.551879699 0 0.448205128 serum_phospholipids serum_phospholipids 5.43E-06 0.0262 no up up no up no Alistipes 16:0/20:4-PC+blood 0.462644803 0 0 Genus serum_phospholipids 0.0114 0.0262 no up no no up no Amyotrophic lateral sclerosis 16:0/20:4-PC+blood 0 0 -0.400769231 kegg serum_phospholipids NA 0.0262 no no no no up no Asthma 16:0/20:4-PC+blood 0 0 -0.504615385 kegg serum_phospholipids NA 0.0262 no no no no up no Autophagy - animal 16:0/20:4-PC+blood 0 0 0.451538462 kegg serum_phospholipids NA 0.0262 no no no no up no Axon guidance 16:0/20:4-PC+blood 0 -0.576470588 0 kegg serum_phospholipids NA 0.0262 no up up no up no Cardiac muscle contraction 16:0/20:4-PC+blood 0 0 -0.405384615 kegg serum_phospholipids NA 0.0262 no no up no up no Diabetic cardiomyopathy 16:0/20:4-PC+blood 0 0 -0.448461538 kegg serum_phospholipids NA 0.0262 no no no no up no Dilated cardiomyopathy 16:0/20:4-PC+blood 0 0 -0.428461538 kegg serum_phospholipids NA 0.0262 no up up no up no Gastric acid secretion 16:0/20:4-PC+blood 0 0 -0.450769231 kegg serum_phospholipids NA 0.0262 no no no no up no HDCA+stool 16:0/20:4-PC+blood 0.598901099 0 0 stool_bileacids serum_phospholipids 0.176 0.0262 no no no no up no Hematopoietic cell lineage 16:0/20:4-PC+blood 0 0 -0.503076923 kegg serum_phospholipids NA 0.0262 no no no no up no Hepatocellular carcinoma 16:0/20:4-PC+blood 0 0 -0.438461538 kegg serum_phospholipids NA 0.0262 no no no no up no Inflammatory bowel disease 16:0/20:4-PC+blood 0 0 -0.534615385 kegg serum_phospholipids NA 0.0262 no no no no up no Lachnospira 16:0/20:4-PC+blood 0 0 0.531850095 butyrate-producing Genus serum_phospholipids 0.279 0.0262 no no no no up no MAPK signaling pathway 16:0/20:4-PC+blood 0 0 0.409230769 kegg serum_phospholipids NA 0.0262 no no no no up no Prion disease 16:0/20:4-PC+blood 0 0 -0.436153846 kegg serum_phospholipids NA 0.0262 no no no no up no Renal cell carcinoma 16:0/20:4-PC+blood 0 -0.526470588 0 kegg serum_phospholipids NA 0.0262 no no no no up no Th1 and Th2 cell differentiation 16:0/20:4-PC+blood 0.512280702 0 0 kegg serum_phospholipids NA 0.0262 no no no no up no Th17 cell differentiation 16:0/20:4-PC+blood 0.461403509 0 0 kegg serum_phospholipids NA 0.0262 no no no no up no Thermogenesis 16:0/20:4-PC+blood 0 0 -0.413076923 kegg serum_phospholipids NA 0.0262 no no no no up no Thyroid hormone signaling pathway 16:0/20:4-PC+blood 0 0 -0.523076923 kegg serum_phospholipids NA 0.0262 no no no no up no 11-HETE+blood 16:0/20:4-PE+blood 0 0.501879937 0 serum_ARA serum_phospholipids 0.464 0.00139 no no no up up no 12-ketoDCA+blood 16:0/20:4-PE+blood 0 -0.576306805 0 serum_bileacids serum_phospholipids 0.517 0.00139 no no no up up no 15-HETE+blood 16:0/20:4-PE+blood -0.496983959 0 0 serum_ARA serum_phospholipids 0.819 0.00139 no no no up up no 16:0-LPE+blood 16:0/20:4-PE+blood 0.657142857 0.595588235 0.448205128 serum_phospholipids serum_phospholipids 0.0711 0.00139 up up no up up no 16:0/16:0-PI+blood 16:0/20:4-PE+blood 0.479699248 0 0 serum_phospholipids serum_phospholipids 0.358 0.00139 no no no up up no 16:0/18:0-PC+blood 16:0/20:4-PE+blood 0 0 -0.498803419 serum_phospholipids serum_phospholipids 0.521 0.00139 no no no up up no 16:0/18:0-PS+blood 16:0/20:4-PE+blood 0.705263158 0.495098039 0.515897436 serum_phospholipids serum_phospholipids 0.377 0.00139 no no no up up no 16:0/18:1-PE+blood 16:0/20:4-PE+blood 0.809022556 0.828431373 0.868717949 serum_phospholipids serum_phospholipids 0.000107 0.00139 up up no up up no 16:0/20:3-PC+blood 16:0/20:4-PE+blood -0.589473684 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.00139 no up up up up no 11-HETE+blood 16:0/20:4-PI+blood -0.487119845 0 0 serum_ARA serum_phospholipids 0.464 0.558 no no no no no no 13-HODE+blood 16:0/20:4-PI+blood 0 -0.593137255 0 serum_ARA serum_phospholipids 0.32 0.558 no no no no no no 14:0-LPC+blood 16:0/20:4-PI+blood 0.57593985 0 0.557606838 serum_phospholipids serum_phospholipids 0.00689 0.558 up up no no no no 14:0/16:0-PC+blood 16:0/20:4-PI+blood 0 0 0.538461538 serum_phospholipids serum_phospholipids 0.0358 0.558 no up no no no no 14:0/18:0-PC+blood 16:0/20:4-PI+blood 0 0 0.51042735 serum_phospholipids serum_phospholipids 0.00289 0.558 up up no no no no 14:0/20:4-PC+blood 16:0/20:4-PI+blood 0.487218045 0 0 serum_phospholipids serum_phospholipids 0.486 0.558 no no no no no no 14:0+blood 16:0/20:4-PI+blood 0.448120301 0 0 yes serum_fattyacid serum_phospholipids 0.00572 0.558 up no dn no no no 14:1/18:2-PG+blood 16:0/20:4-PI+blood 0 0 0.483076923 serum_phospholipids serum_phospholipids 0.00259 0.558 no up up no no no 16:0/16:0-PI+blood 16:0/20:4-PI+blood 0.741353383 0 0.672478632 serum_phospholipids serum_phospholipids 0.358 0.558 no no no no no no 16:0/16:1-PC+blood 16:0/20:4-PI+blood 0 0 0.548717949 serum_phospholipids serum_phospholipids 0.00283 0.558 up up no no no no 16:0/16:1-PI+blood 16:0/20:4-PI+blood 0.781954887 0.615196078 0.811282051 serum_phospholipids serum_phospholipids 0.262 0.558 no no no no no no 16:0/18:1-PC+blood 16:0/20:4-PI+blood -0.669172932 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.558 up up up no no no 16:0/18:1-PE+blood 16:0/20:4-PI+blood 0 0 0.458461538 serum_phospholipids serum_phospholipids 0.000107 0.558 up up no no no no 16:0/18:2-PC+blood 16:0/20:4-PI+blood -0.536842105 -0.580882353 0 serum_phospholipids serum_phospholipids 3.24E-06 0.558 no up up no no no 16:0/18:2-PI+blood 16:0/20:4-PI+blood 0.810526316 0.602941176 0.848205128 serum_phospholipids serum_phospholipids 0.269 0.558 no no no no no no 16:0/18:3-PC+blood 16:0/20:4-PI+blood 0 0 0.476239316 serum_phospholipids serum_phospholipids 0.00216 0.558 no up up no no no 16:0/20:3-PC+blood 16:0/20:4-PI+blood -0.547368421 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.558 no up up no no no 16:0/20:4-PC+blood 16:0/20:4-PI+blood 0 -0.661764706 0 serum_phospholipids serum_phospholipids 0.0262 0.558 no up no no no no 16:0+blood 16:0/20:4-PI+blood 0 0 0.476923077 yes serum_fattyacid serum_phospholipids 0.00876 0.558 up no no no no no Adipocytokine signaling pathway 16:0/20:4-PI+blood 0 0 0.419230769 kegg serum_phospholipids NA 0.558 no no no no no no Alcoholism 16:0/20:4-PI+blood 0 0 0.417692308 kegg serum_phospholipids NA 0.558 no no no no no no Aldosterone synthesis and secretion 16:0/20:4-PI+blood 0 0 0.425384615 kegg serum_phospholipids NA 0.558 no up up no no no Amphetamine addiction 16:0/20:4-PI+blood 0 0 0.42 kegg serum_phospholipids NA 0.558 no no no no no no Apoptosis 16:0/20:4-PI+blood -0.466666667 0 0 kegg serum_phospholipids NA 0.558 no no no no no no Asthma 16:0/20:4-PI+blood -0.556140351 0 0 kegg serum_phospholipids NA 0.558 no no no no no no C-type lectin receptor signaling pathway 16:0/20:4-PI+blood 0 0 0.437692308 kegg serum_phospholipids NA 0.558 no no no no no no Calcium signaling pathway 16:0/20:4-PI+blood 0 0 0.557692308 kegg serum_phospholipids NA 0.558 no up up no no no cAMP signaling pathway 16:0/20:4-PI+blood 0 0 0.635384615 yes kegg serum_phospholipids NA 0.558 no up up no no no Carbon metabolism 16:0/20:4-PI+blood 0 0 -0.503076923 kegg serum_phospholipids NA 0.558 no no no no no no Central carbon metabolism in cancer 16:0/20:4-PI+blood 0.477192982 0 0 kegg serum_phospholipids NA 0.558 no no no no no no Chagas disease 16:0/20:4-PI+blood 0 0 0.408461538 kegg serum_phospholipids NA 0.558 no no no no no no Cocaine addiction 16:0/20:4-PI+blood 0 0 0.687692308 kegg serum_phospholipids NA 0.558 no no no no no no Coprococcus 16:0/20:4-PI+blood 0.607518797 0 0 butyrate-producing Genus serum_phospholipids 0.612 0.558 no no no no no no Cortisol synthesis and secretion 16:0/20:4-PI+blood 0 0 0.593076923 kegg serum_phospholipids NA 0.558 no no up no no no Cushing syndrome 16:0/20:4-PI+blood 0 0 0.496923077 kegg serum_phospholipids NA 0.558 no no up no no no Cytosolic DNA-sensing pathway 16:0/20:4-PI+blood 0 0 0.517692308 kegg serum_phospholipids NA 0.558 no no no no no no FoxO signaling pathway 16:0/20:4-PI+blood 0 0 -0.416153846 kegg serum_phospholipids NA 0.558 no no no no no no Glycolysis / Gluconeogenesis 16:0/20:4-PI+blood 0 0 -0.506923077 kegg serum_phospholipids NA 0.558 no no no no no no GnRH signaling pathway 16:0/20:4-PI+blood 0 0 0.461538462 kegg serum_phospholipids NA 0.558 no no no no no no "Growth hormone synthesis, secretion and action" 16:0/20:4-PI+blood 0 0 0.463076923 kegg serum_phospholipids NA 0.558 no no no no no no HDCA+stool 16:0/20:4-PI+blood 0 -0.772727273 0 stool_bileacids serum_phospholipids 0.176 0.558 no no no no no no Hepatitis B 16:0/20:4-PI+blood 0 0 0.432307692 kegg serum_phospholipids NA 0.558 no no no no no no Hepatitis C 16:0/20:4-PI+blood 0 0 0.510769231 kegg serum_phospholipids NA 0.558 no no no no no no Inflammatory bowel disease 16:0/20:4-PI+blood -0.492982456 0 0 kegg serum_phospholipids NA 0.558 no no no no no no Influenza A 16:0/20:4-PI+blood -0.671929825 0 0 kegg serum_phospholipids NA 0.558 no no no no no no Insulin secretion 16:0/20:4-PI+blood 0 0 0.549230769 yes kegg serum_phospholipids NA 0.558 no up up no no no Insulin signaling pathway 16:0/20:4-PI+blood 0.457894737 0 0 kegg serum_phospholipids NA 0.558 no no no no no no Intestinal immune network for IgA production 16:0/20:4-PI+blood -0.5 0 0 kegg serum_phospholipids NA 0.558 no no no no no no Kaposi sarcoma-associated herpesvirus infection 16:0/20:4-PI+blood 0 0 0.435384615 kegg serum_phospholipids NA 0.558 no no dn no no no Legionellosis 16:0/20:4-PI+blood 0.475438596 0 0 kegg serum_phospholipids NA 0.558 no no no no no no Long-term depression 16:0/20:4-PI+blood 0 0 0.513846154 kegg serum_phospholipids NA 0.558 no no no no no no Longevity regulating pathway - multiple species 16:0/20:4-PI+blood 0.578947368 0 -0.528461538 kegg serum_phospholipids NA 0.558 no no no no no no Melanogenesis 16:0/20:4-PI+blood 0 0 0.438461538 kegg serum_phospholipids NA 0.558 no no no no no no Morphine addiction 16:0/20:4-PI+blood 0 0 0.446153846 kegg serum_phospholipids NA 0.558 no up up no no no Neurotrophin signaling pathway 16:0/20:4-PI+blood 0 0 0.486153846 kegg serum_phospholipids NA 0.558 no no no no no no Odoribacter 16:0/20:4-PI+blood 0 0.541998876 0 butyrate-producing Genus serum_phospholipids 0.798 0.558 no no no no no no "Parathyroid hormone synthesis, secretion and action" 16:0/20:4-PI+blood 0 0 0.45 kegg serum_phospholipids NA 0.558 no no no no no no Pathways in cancer 16:0/20:4-PI+blood 0 -0.552941176 0 kegg serum_phospholipids NA 0.558 no no no no no no Phenylacetic acid+stool 16:0/20:4-PI+blood -0.741758242 0 0 stool_cometabolism serum_phospholipids 0.785 0.558 no no no no no no PI3K-Akt signaling pathway 16:0/20:4-PI+blood 0.563157895 0 0 yes kegg serum_phospholipids NA 0.558 no up up no no no Primary immunodeficiency 16:0/20:4-PI+blood 0.587719298 0 -0.576923077 kegg serum_phospholipids NA 0.558 no no no no no no Prostate cancer 16:0/20:4-PI+blood 0 0 0.520769231 kegg serum_phospholipids NA 0.558 no no no no no no Relaxin signaling pathway 16:0/20:4-PI+blood 0 0 0.64 kegg serum_phospholipids NA 0.558 no no no no no no Rheumatoid arthritis 16:0/20:4-PI+blood -0.489473684 0 0 kegg serum_phospholipids NA 0.558 no no no no no no RIG-I-like receptor signaling pathway 16:0/20:4-PI+blood 0 0 0.504615385 kegg serum_phospholipids NA 0.558 no no no no no no RNA transport 16:0/20:4-PI+blood 0.556140351 0 0 kegg serum_phospholipids NA 0.558 no no no no no no Ruminococcus 16:0/20:4-PI+blood 0 0 0.498452965 Genus serum_phospholipids 0.0679 0.558 no no dn no no no Small cell lung cancer 16:0/20:4-PI+blood 0 0 0.483846154 kegg serum_phospholipids NA 0.558 no no up no no no TCA+stool 16:0/20:4-PI+blood 0.591472361 0 0 stool_bileacids serum_phospholipids 0.458 0.558 no no no no no no Th1 and Th2 cell differentiation 16:0/20:4-PI+blood -0.624561404 0 0 kegg serum_phospholipids NA 0.558 no no no no no no Th17 cell differentiation 16:0/20:4-PI+blood -0.554385965 0 0 kegg serum_phospholipids NA 0.558 no no no no no no TNF signaling pathway 16:0/20:4-PI+blood 0 0 0.414615385 kegg serum_phospholipids NA 0.558 no no no no no no Tuberculosis 16:0/20:4-PI+blood 0 0 -0.403076923 kegg serum_phospholipids NA 0.558 no no dn no no no 12-HEPE+blood 16:0/20:5-PC+blood 0 0.493977261 0 serum_ARA serum_phospholipids 0.312 0.628 no no no no no no 14:0/20:4-PC+blood 16:0/20:5-PC+blood 0.57593985 0 0 serum_phospholipids serum_phospholipids 0.486 0.628 no no no no no no 16:0/18:0-PC+blood 16:0/20:5-PC+blood 0 0.583333333 0 serum_phospholipids serum_phospholipids 0.521 0.628 no no no no no no 16:0/18:0-PS+blood 16:0/20:5-PC+blood 0 0.504901961 0 serum_phospholipids serum_phospholipids 0.377 0.628 no no no no no no 16:0/18:1-PE+blood 16:0/20:5-PC+blood 0 -0.5 0 serum_phospholipids serum_phospholipids 0.000107 0.628 up up no no no no 16:0/18:3-PC+blood 16:0/20:5-PC+blood 0 0.541666667 0 serum_phospholipids serum_phospholipids 0.00216 0.628 no up up no no no 16:0/20:3-PC+blood 16:0/20:5-PC+blood 0 0 -0.533675214 serum_phospholipids serum_phospholipids 5.43E-06 0.628 no up up no no no Adlercreutzia 16:0/20:5-PC+blood 0 0 -0.40383105 Genus serum_phospholipids 0.548 0.628 no no no no no no Amoebiasis 16:0/20:5-PC+blood 0 -0.523529412 0 kegg serum_phospholipids NA 0.628 no no no no no no Bacteroides 16:0/20:5-PC+blood 0 0.578431373 0 LPS-producing Genus serum_phospholipids 0.000267 0.628 dn dn up no no no Blautia 16:0/20:5-PC+blood 0.446616541 0 0 acetate-producing Genus serum_phospholipids 1.36E-05 0.628 up dn dn no no no Butyric acid+stool 16:0/20:5-PC+blood 0 -0.672727273 0 yes stool_scfa serum_phospholipids 0.102 0.628 dn no no no no no cAMP signaling pathway 16:0/20:5-PC+blood 0 -0.579411765 0 yes kegg serum_phospholipids NA 0.628 no up up no no no Cholinergic synapse 16:0/20:5-PC+blood 0 0.514705882 0 kegg serum_phospholipids NA 0.628 no no no no no no Clostridium 16:0/20:5-PC+blood 0 -0.491722962 0 Genus serum_phospholipids 0.925 0.628 no no no no no no Coprococcus 16:0/20:5-PC+blood 0.613533835 0 0 butyrate-producing Genus serum_phospholipids 0.612 0.628 no no no no no no Ferroptosis 16:0/20:5-PC+blood 0 -0.573529412 0 kegg serum_phospholipids NA 0.628 no no no no no no Hematopoietic cell lineage 16:0/20:5-PC+blood 0 0.564705882 0 kegg serum_phospholipids NA 0.628 no no no no no no Kaposi sarcoma-associated herpesvirus infection 16:0/20:5-PC+blood 0 -0.711764706 0 kegg serum_phospholipids NA 0.628 no no dn no no no Malaria 16:0/20:5-PC+blood 0 -0.576470588 0 kegg serum_phospholipids NA 0.628 no no no no no no MAPK signaling pathway 16:0/20:5-PC+blood 0 0.597058824 0 kegg serum_phospholipids NA 0.628 no no no no no no Parabacteroides 16:0/20:5-PC+blood 0 0.551470588 0 Genus serum_phospholipids 4.19E-05 0.628 no up up no no no Primary immunodeficiency 16:0/20:5-PC+blood 0 0.514705882 0 kegg serum_phospholipids NA 0.628 no no no no no no Progesterone-mediated oocyte maturation 16:0/20:5-PC+blood 0 0.511764706 0 kegg serum_phospholipids NA 0.628 no no no no no no Propionic acid+stool 16:0/20:5-PC+blood 0 0 0.545864662 yes stool_scfa serum_phospholipids 0.0436 0.628 dn no up no no no Renal cell carcinoma 16:0/20:5-PC+blood -0.5 0 0 kegg serum_phospholipids NA 0.628 no no no no no no Shigellosis 16:0/20:5-PC+blood 0 -0.573529412 0 kegg serum_phospholipids NA 0.628 no no no no no no TCA+stool 16:0/20:5-PC+blood 0 0 -0.526315789 stool_bileacids serum_phospholipids 0.458 0.628 no no no no no no Viral protein interaction with cytokine and cytokine receptor 16:0/20:5-PC+blood 0 -0.541176471 0 kegg serum_phospholipids NA 0.628 no no no no no no "12,13-EPOME+blood" 16:0/20:5-PG+blood 0 -0.655135439 0 serum_ARA serum_phospholipids 0.901 0.00656 no no no no up no 13-HODE+blood 16:0/20:5-PG+blood 0 0 -0.528888889 serum_ARA serum_phospholipids 0.32 0.00656 no no no no up no 14:0-LPC+blood 16:0/20:5-PG+blood -0.676691729 0 0 serum_phospholipids serum_phospholipids 0.00689 0.00656 up up no no up no 14:0/18:2-PC+blood 16:0/20:5-PG+blood -0.467669173 0 0 serum_phospholipids serum_phospholipids 0.102 0.00656 no up no no up no 14:0+blood 16:0/20:5-PG+blood -0.461654135 0 0 yes serum_fattyacid serum_phospholipids 0.00572 0.00656 up no dn no up no 14:1/18:2-PG+blood 16:0/20:5-PG+blood -0.515789474 0 0 serum_phospholipids serum_phospholipids 0.00259 0.00656 no up up no up no 16:0/14:0-PC+blood 16:0/20:5-PG+blood 0 -0.531862745 0 serum_phospholipids serum_phospholipids 0.0206 0.00656 no up up no up no 16:0/16:1-PI+blood 16:0/20:5-PG+blood -0.479699248 0 0 serum_phospholipids serum_phospholipids 0.262 0.00656 no no no no up no 16:0/18:0-PS+blood 16:0/20:5-PG+blood 0 0 0.461880342 serum_phospholipids serum_phospholipids 0.377 0.00656 no no no no up no 16:0/18:2-PI+blood 16:0/20:5-PG+blood -0.569924812 0 0 serum_phospholipids serum_phospholipids 0.269 0.00656 no no no no up no 16:0/20:4-PC+blood 16:0/20:5-PG+blood 0.527819549 0 0 serum_phospholipids serum_phospholipids 0.0262 0.00656 no up no no up no 16:0-LPE+blood 16:0/22:0-PE+blood 0 -0.551470588 0 serum_phospholipids serum_phospholipids 0.0711 0.00839 up up no dn no up 16:0/16:1-PI+blood 16:0/22:0-PE+blood 0 0 -0.517948718 serum_phospholipids serum_phospholipids 0.262 0.00839 no no no dn no up 16:0/18:0-PC+blood 16:0/22:0-PE+blood 0 0 0.616410256 serum_phospholipids serum_phospholipids 0.521 0.00839 no no no dn no up 16:0/18:2-PI+blood 16:0/22:0-PE+blood 0 0 -0.414017094 serum_phospholipids serum_phospholipids 0.269 0.00839 no no no dn no up 16:0/20:4-PI+blood 16:0/22:0-PE+blood 0 0 -0.439316239 serum_phospholipids serum_phospholipids 0.558 0.00839 no no no dn no up 16:0/20:5-PC+blood 16:0/22:0-PE+blood 0 0.634803922 0 serum_phospholipids serum_phospholipids 0.628 0.00839 no no no dn no up 14:0-LPC+blood 16:0/22:6-PC+blood 0 -0.509803922 0 serum_phospholipids serum_phospholipids 0.00689 4.53E-05 up up no no up up 14:0/18:0-PC+blood 16:0/22:6-PC+blood 0 -0.595588235 0 serum_phospholipids serum_phospholipids 0.00289 4.53E-05 up up no no up up 14:0/20:4-PC+blood 16:0/22:6-PC+blood 0 0 -0.481025641 serum_phospholipids serum_phospholipids 0.486 4.53E-05 no no no no up up 14:1/18:2-PG+blood 16:0/22:6-PC+blood 0 0 -0.437948718 serum_phospholipids serum_phospholipids 0.00259 4.53E-05 no up up no up up 16:0/14:0-PC+blood 16:0/22:6-PC+blood 0 0 0.513162393 serum_phospholipids serum_phospholipids 0.0206 4.53E-05 no up up no up up 16:0/16:0-PC+blood 16:0/22:6-PC+blood 0.622556391 0 0.487863248 serum_phospholipids serum_phospholipids 0.00079 4.53E-05 no up up no up up 16:0/16:0-PI+blood 16:0/22:6-PC+blood 0 -0.68872549 0 serum_phospholipids serum_phospholipids 0.358 4.53E-05 no no no no up up 16:0/16:1-PC+blood 16:0/22:6-PC+blood 0 -0.568627451 0 serum_phospholipids serum_phospholipids 0.00283 4.53E-05 up up no no up up 16:0/16:1-PI+blood 16:0/22:6-PC+blood -0.479699248 -0.620098039 0 serum_phospholipids serum_phospholipids 0.262 4.53E-05 no no no no up up 16:0/18:0-PC+blood 16:0/22:6-PC+blood 0.496240602 0 0.424273504 serum_phospholipids serum_phospholipids 0.521 4.53E-05 no no no no up up 16:0/18:1-PC+blood 16:0/22:6-PC+blood 0.479699248 0.585784314 0.478974359 serum_phospholipids serum_phospholipids 6.15E-07 4.53E-05 up up up no up up 16:0/18:1-PE+blood 16:0/22:6-PC+blood 0 -0.539215686 0 serum_phospholipids serum_phospholipids 0.000107 4.53E-05 up up no no up up 16:0/18:2-PC+blood 16:0/22:6-PC+blood 0.604511278 0 0.74974359 serum_phospholipids serum_phospholipids 3.24E-06 4.53E-05 no up up no up up 16:0/18:2-PI+blood 16:0/22:6-PC+blood 0 -0.632352941 0 serum_phospholipids serum_phospholipids 0.269 4.53E-05 no no no no up up 16:0/20:4-PC+blood 16:0/22:6-PC+blood 0 0.764705882 0 serum_phospholipids serum_phospholipids 0.0262 4.53E-05 no up no no up up 16:0/20:5-PC+blood 16:0/22:6-PC+blood 0 0.588235294 0 serum_phospholipids serum_phospholipids 0.628 4.53E-05 no no no no up up 16:0/22:0-PE+blood 16:0/22:6-PC+blood 0.777443609 0.632352941 0.643076923 serum_phospholipids serum_phospholipids 0.00839 4.53E-05 dn no up no up up AGE-RAGE signaling pathway in diabetic complications 16:0/22:6-PC+blood 0.521052632 0 0 kegg serum_phospholipids NA 4.53E-05 no no no no up up Alzheimer disease 16:0/22:6-PC+blood 0 0 -0.438461538 kegg serum_phospholipids NA 4.53E-05 no no no no up up Amyotrophic lateral sclerosis 16:0/22:6-PC+blood 0 0 -0.436923077 kegg serum_phospholipids NA 4.53E-05 no no no no up up Bacteroides 16:0/22:6-PC+blood 0 0.536764706 0 LPS-producing Genus serum_phospholipids 0.000267 4.53E-05 dn dn up no up up Blautia 16:0/22:6-PC+blood 0 0 -0.418184279 acetate-producing Genus serum_phospholipids 1.36E-05 4.53E-05 up dn dn no up up CA+stool 16:0/22:6-PC+blood 0 0 -0.445112782 stool_bileacids serum_phospholipids 0.827 4.53E-05 no no no no up up Carbon metabolism 16:0/22:6-PC+blood 0 0 0.404615385 kegg serum_phospholipids NA 4.53E-05 no no no no up up Cardiac muscle contraction 16:0/22:6-PC+blood 0 0 -0.455384615 kegg serum_phospholipids NA 4.53E-05 no no up no up up CDCA+stool 16:0/22:6-PC+blood 0 0 -0.482706767 stool_bileacids serum_phospholipids 0.663 4.53E-05 no no no no up up IL-17 signaling pathway 16:0/22:6-PC+blood 0 0 0.41 kegg serum_phospholipids NA 4.53E-05 no no no no up up Kaposi sarcoma-associated herpesvirus infection 16:0/22:6-PC+blood 0 -0.647058824 0 kegg serum_phospholipids NA 4.53E-05 no no dn no up up L-Phenylalanine+stool 16:0/22:6-PC+blood 0 0 0.639097744 stool_cometabolism serum_phospholipids 0.398 4.53E-05 no no no no up up L-Tryptophan+stool 16:0/22:6-PC+blood 0 0 0.562406015 stool_cometabolism serum_phospholipids 0.557 4.53E-05 no no no no up up L-Tyrosine+stool 16:0/22:6-PC+blood 0 0 0.634586466 stool_cometabolism serum_phospholipids 0.44 4.53E-05 no no no no up up Lysosome 16:0/22:6-PC+blood 0 0 0.426153846 kegg serum_phospholipids NA 4.53E-05 no no no no up up MAPK signaling pathway 16:0/22:6-PC+blood 0 0.544117647 0 kegg serum_phospholipids NA 4.53E-05 no no no no up up Parabacteroides 16:0/22:6-PC+blood 0 0.531862745 0 Genus serum_phospholipids 4.19E-05 4.53E-05 no up up no up up Peroxisome 16:0/22:6-PC+blood 0 0 0.467692308 kegg serum_phospholipids NA 4.53E-05 no no no no up up Pertussis 16:0/22:6-PC+blood 0.471929825 0 0 kegg serum_phospholipids NA 4.53E-05 no no dn no up up Renal cell carcinoma 16:0/22:6-PC+blood 0 -0.5 0 kegg serum_phospholipids NA 4.53E-05 no no no no up up Retrograde endocannabinoid signaling 16:0/22:6-PC+blood 0 0 -0.406923077 kegg serum_phospholipids NA 4.53E-05 no no up no up up Shigellosis 16:0/22:6-PC+blood 0 -0.529411765 0 kegg serum_phospholipids NA 4.53E-05 no no no no up up TCA+stool 16:0/22:6-PC+blood 0 -0.627272727 0 stool_bileacids serum_phospholipids 0.458 4.53E-05 no no no no up up UDCA+stool 16:0/22:6-PC+blood 0 0 -0.466165414 stool_bileacids serum_phospholipids 0.266 4.53E-05 no no no no up up 12-ketoDCA+blood 16:0/22:6-PE+blood 0 -0.513736352 0 serum_bileacids serum_phospholipids 0.517 0.000934 no no no up up no 12-ketoDCA+stool 16:0/22:6-PE+blood 0 0 0.578947368 stool_bileacids serum_phospholipids 0.505 0.000934 no no no up up no 16:0-LPE+blood 16:0/22:6-PE+blood 0.57443609 0 0.462564103 serum_phospholipids serum_phospholipids 0.0711 0.000934 up up no up up no 16:0/18:0-PS+blood 16:0/22:6-PE+blood 0.870676692 0.75 0.610940171 serum_phospholipids serum_phospholipids 0.377 0.000934 no no no up up no 16:0/18:1-PE+blood 16:0/22:6-PE+blood 0.717293233 0.492647059 0.890598291 serum_phospholipids serum_phospholipids 0.000107 0.000934 up up no up up no 16:0/20:3-PC+blood 16:0/22:6-PE+blood -0.473684211 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.000934 no up up up up no 16:0/20:4-PE+blood 16:0/22:6-PE+blood 0.765413534 0.767156863 0.909059829 serum_phospholipids serum_phospholipids 0.00139 0.000934 up up no up up no Adrenergic signaling in cardiomyocytes 16:0/22:6-PE+blood -0.477192982 0 0 kegg serum_phospholipids NA 0.000934 no no up up up no Allograft rejection 16:0/22:6-PE+blood 0 0 0.403846154 kegg serum_phospholipids NA 0.000934 no no no up up no Amoebiasis 16:0/22:6-PE+blood 0 0 0.429230769 kegg serum_phospholipids NA 0.000934 no no no up up no Antigen processing and presentation 16:0/22:6-PE+blood 0 0 0.499230769 kegg serum_phospholipids NA 0.000934 no no no up up no Autoimmune thyroid disease 16:0/22:6-PE+blood 0 0 0.403846154 kegg serum_phospholipids NA 0.000934 no no no up up no Axon guidance 16:0/22:6-PE+blood 0 0 0.421538462 kegg serum_phospholipids NA 0.000934 no up up up up no Calcium signaling pathway 16:0/22:6-PE+blood -0.466666667 0 0 kegg serum_phospholipids NA 0.000934 no up up up up no Cell adhesion molecules 16:0/22:6-PE+blood 0 0 0.498461538 kegg serum_phospholipids NA 0.000934 no no no up up no Cellular senescence 16:0/22:6-PE+blood 0 0 0.465384615 kegg serum_phospholipids NA 0.000934 no no no up up no cGMP-PKG signaling pathway 16:0/22:6-PE+blood 0 0 0.564615385 kegg serum_phospholipids NA 0.000934 no no no up up no Chagas disease 16:0/22:6-PE+blood 0 0 0.508461538 kegg serum_phospholipids NA 0.000934 no no no up up no Cholinergic synapse 16:0/22:6-PE+blood 0 0.538235294 0 kegg serum_phospholipids NA 0.000934 no no no up up no Coronavirus disease - COVID-19 16:0/22:6-PE+blood -0.547368421 0 0 kegg serum_phospholipids NA 0.000934 no no no up up no Endocytosis 16:0/22:6-PE+blood 0 0 0.458461538 kegg serum_phospholipids NA 0.000934 no no no up up no Epithelial cell signaling in Helicobacter pylori infection 16:0/22:6-PE+blood 0 0 0.560769231 kegg serum_phospholipids NA 0.000934 no no no up up no Epstein-Barr virus infection 16:0/22:6-PE+blood 0 0 0.522307692 kegg serum_phospholipids NA 0.000934 no no no up up no Fc gamma R-mediated phagocytosis 16:0/22:6-PE+blood 0.557894737 0 0.421538462 kegg serum_phospholipids NA 0.000934 no no no up up no Ferroptosis 16:0/22:6-PE+blood -0.471929825 0 0 kegg serum_phospholipids NA 0.000934 no no no up up no GABAergic synapse 16:0/22:6-PE+blood 0 0 0.445384615 kegg serum_phospholipids NA 0.000934 no up up up up no GCA+stool 16:0/22:6-PE+blood 0.620879121 0 0 stool_bileacids serum_phospholipids 0.0809 0.000934 no no no up up no Graft-versus-host disease 16:0/22:6-PE+blood 0 0 0.437692308 kegg serum_phospholipids NA 0.000934 no no no up up no Herpes simplex virus 1 infection 16:0/22:6-PE+blood 0 0 0.421538462 kegg serum_phospholipids NA 0.000934 no no no up up no Human cytomegalovirus infection 16:0/22:6-PE+blood 0 0 0.638461538 kegg serum_phospholipids NA 0.000934 no no dn up up no Human immunodeficiency virus 1 infection 16:0/22:6-PE+blood 0 0 0.573846154 kegg serum_phospholipids NA 0.000934 no no no up up no Human papillomavirus infection 16:0/22:6-PE+blood 0 0 0.533076923 kegg serum_phospholipids NA 0.000934 no no no up up no Human T-cell leukemia virus 1 infection 16:0/22:6-PE+blood 0 0 0.511538462 kegg serum_phospholipids NA 0.000934 no no no up up no IL-17 signaling pathway 16:0/22:6-PE+blood 0 0 0.484615385 kegg serum_phospholipids NA 0.000934 no no no up up no Intestinal immune network for IgA production 16:0/22:6-PE+blood -0.731578947 0 0 kegg serum_phospholipids NA 0.000934 no no no up up no Kaposi sarcoma-associated herpesvirus infection 16:0/22:6-PE+blood -0.587719298 0 0 kegg serum_phospholipids NA 0.000934 no no dn up up no L-Phenylalanine+stool 16:0/22:6-PE+blood 0.708791209 0 0 stool_cometabolism serum_phospholipids 0.398 0.000934 no no no up up no L-Tryptophan+stool 16:0/22:6-PE+blood 0.71978022 0 0 stool_cometabolism serum_phospholipids 0.557 0.000934 no no no up up no L-Tyrosine+stool 16:0/22:6-PE+blood 0.587912088 0 -0.457142857 stool_cometabolism serum_phospholipids 0.44 0.000934 no no no up up no Lachnospira 16:0/22:6-PE+blood 0.476691729 0 0 butyrate-producing Genus serum_phospholipids 0.279 0.000934 no no no up up no Lipid and atherosclerosis 16:0/22:6-PE+blood 0 0 0.568461538 kegg serum_phospholipids NA 0.000934 no no no up up no Longevity regulating pathway - multiple species 16:0/22:6-PE+blood 0.477192982 0 0 kegg serum_phospholipids NA 0.000934 no no no up up no MAPK signaling pathway 16:0/22:6-PE+blood 0.484210526 0 0 kegg serum_phospholipids NA 0.000934 no no no up up no Mineral absorption 16:0/22:6-PE+blood -0.485964912 0 0 kegg serum_phospholipids NA 0.000934 no no no up up no Mitophagy - animal 16:0/22:6-PE+blood -0.487719298 0 0 kegg serum_phospholipids NA 0.000934 no no no up up no Natural killer cell mediated cytotoxicity 16:0/22:6-PE+blood 0 0 0.503076923 kegg serum_phospholipids NA 0.000934 no no no up up no Necroptosis 16:0/22:6-PE+blood -0.512280702 0 0 kegg serum_phospholipids NA 0.000934 no no no up up no Neuroactive ligand-receptor interaction 16:0/22:6-PE+blood 0 0 0.408461538 kegg serum_phospholipids NA 0.000934 up up up up up no Neutrophil extracellular trap formation 16:0/22:6-PE+blood 0 0 0.415384615 kegg serum_phospholipids NA 0.000934 no no no up up no Olfactory transduction 16:0/22:6-PE+blood 0.578947368 0 0 kegg serum_phospholipids NA 0.000934 no no no up up no Osteoclast differentiation 16:0/22:6-PE+blood 0.531578947 0 0.509230769 kegg serum_phospholipids NA 0.000934 no no no up up no Pertussis 16:0/22:6-PE+blood 0 0 0.552307692 kegg serum_phospholipids NA 0.000934 no no dn up up no Phagosome 16:0/22:6-PE+blood 0 0 0.44 kegg serum_phospholipids NA 0.000934 no no no up up no Platinum drug resistance 16:0/22:6-PE+blood 0 0 -0.464615385 kegg serum_phospholipids NA 0.000934 no no no up up no PPAR signaling pathway 16:0/22:6-PE+blood 0 0 0.698461538 kegg serum_phospholipids NA 0.000934 no no no up up no Ribosome 16:0/22:6-PE+blood -0.547368421 0 0 kegg serum_phospholipids NA 0.000934 no no no up up no Ribosome biogenesis in eukaryotes 16:0/22:6-PE+blood 0 0 -0.429230769 kegg serum_phospholipids NA 0.000934 no no no up up no Salmonella infection 16:0/22:6-PE+blood 0.475438596 0 0 kegg serum_phospholipids NA 0.000934 no no no up up no Serotonergic synapse 16:0/22:6-PE+blood 0 0 0.46 kegg serum_phospholipids NA 0.000934 no no no up up no Shigellosis 16:0/22:6-PE+blood -0.464912281 0 0 kegg serum_phospholipids NA 0.000934 no no no up up no Slackia 16:0/22:6-PE+blood 0 0 -0.404920521 Genus serum_phospholipids 0.94 0.000934 no no no up up no Th1 and Th2 cell differentiation 16:0/22:6-PE+blood 0 -0.502941176 0 kegg serum_phospholipids NA 0.000934 no no no up up no Th17 cell differentiation 16:0/22:6-PE+blood 0 -0.558823529 0 kegg serum_phospholipids NA 0.000934 no no no up up no Toll-like receptor signaling pathway 16:0/22:6-PE+blood 0 0 0.515384615 yes kegg serum_phospholipids NA 0.000934 no no no up up no Type I diabetes mellitus 16:0/22:6-PE+blood 0 0 0.406923077 kegg serum_phospholipids NA 0.000934 no no no up up no Viral carcinogenesis 16:0/22:6-PE+blood 0 0 0.541538462 kegg serum_phospholipids NA 0.000934 no no no up up no 12-HEPE+blood 16:0+blood -0.510393425 0 0 yes serum_ARA serum_fattyacid 0.312 0.00876 no no no up no no 14:0-LPC+blood 16:0+blood 0 0 0.476239316 yes serum_phospholipids serum_fattyacid 0.00689 0.00876 up up no up no no 14:0/16:0-PC+blood 16:0+blood 0 0 0.525470085 yes serum_phospholipids serum_fattyacid 0.0358 0.00876 no up no up no no 14:0/18:0-PC+blood 16:0+blood 0 0 0.584273504 yes serum_phospholipids serum_fattyacid 0.00289 0.00876 up up no up no no 14:0/18:2-PC+blood 16:0+blood 0 0 0.418119658 yes serum_phospholipids serum_fattyacid 0.102 0.00876 no up no up no no 14:0+blood 16:0+blood 0.712781955 0 0.617094017 yes yes serum_fattyacid serum_fattyacid 0.00572 0.00876 up no dn up no no Adipocytokine signaling pathway 16:0+blood -0.471929825 0 0 yes kegg serum_fattyacid NA 0.00876 no no no up no no Arginine and proline metabolism 16:0+blood 0 0 0.421538462 yes kegg serum_fattyacid NA 0.00876 no up no up no no Bifidobacterium 16:0+blood 0 -0.496627929 0 acetate-producing yes Genus serum_fattyacid 0.105 0.00876 no dn no up no no Biosynthesis of cofactors 16:0+blood 0 -0.617647059 0 yes kegg serum_fattyacid NA 0.00876 no no no up no no Central carbon metabolism in cancer 16:0+blood 0.578947368 0 0 yes kegg serum_fattyacid NA 0.00876 no no no up no no Cytosolic DNA-sensing pathway 16:0+blood -0.505263158 0 0 yes kegg serum_fattyacid NA 0.00876 no no no up no no Focal adhesion 16:0+blood 0 0 -0.423076923 yes kegg serum_fattyacid NA 0.00876 no up up up no no FoxO signaling pathway 16:0+blood 0 0 -0.483076923 yes kegg serum_fattyacid NA 0.00876 no no no up no no "Glycine, serine and threonine metabolism" 16:0+blood 0 -0.805882353 0 yes kegg serum_fattyacid NA 0.00876 no up no up no no Hippo signaling pathway 16:0+blood 0 0 -0.415384615 yes kegg serum_fattyacid NA 0.00876 no no no up no no Kaposi sarcoma-associated herpesvirus infection 16:0+blood -0.578947368 0 0 yes kegg serum_fattyacid NA 0.00876 no no dn up no no Leukocyte transendothelial migration 16:0+blood 0 0 -0.400769231 yes kegg serum_fattyacid NA 0.00876 no no no up no no Lipid and atherosclerosis 16:0+blood 0.503508772 0 0 yes kegg serum_fattyacid NA 0.00876 no no no up no no Longevity regulating pathway - multiple species 16:0+blood 0.550877193 0 0 yes kegg serum_fattyacid NA 0.00876 no no no up no no mTOR signaling pathway 16:0+blood 0 0 0.408461538 yes kegg serum_fattyacid NA 0.00876 no no no up no no Porphyrin and chlorophyll metabolism 16:0+blood 0 -0.764705882 0 yes kegg serum_fattyacid NA 0.00876 no no no up no no Progesterone-mediated oocyte maturation 16:0+blood 0.505263158 0 0 yes kegg serum_fattyacid NA 0.00876 no no no up no no Purine metabolism 16:0+blood 0 -0.682352941 0 yes kegg serum_fattyacid NA 0.00876 no no no up no no Shigellosis 16:0+blood -0.585964912 0 0 yes kegg serum_fattyacid NA 0.00876 no no no up no no Sphingolipid signaling pathway 16:0+blood 0 0 -0.449230769 yes kegg serum_fattyacid NA 0.00876 no no no up no no 14:0-LPC+blood 16:1-LPC+blood 0 0 0.684786325 serum_phospholipids serum_phospholipids 0.00689 0.0241 up up no no up no 14:0/16:0-PC+blood 16:1-LPC+blood 0 0 0.555555556 serum_phospholipids serum_phospholipids 0.0358 0.0241 no up no no up no 14:0/18:0-PC+blood 16:1-LPC+blood 0 0 0.600683761 serum_phospholipids serum_phospholipids 0.00289 0.0241 up up no no up no 14:0/18:2-PC+blood 16:1-LPC+blood 0 0 0.494700855 serum_phospholipids serum_phospholipids 0.102 0.0241 no up no no up no 14:0+blood 16:1-LPC+blood 0 0 0.561709402 yes serum_fattyacid serum_phospholipids 0.00572 0.0241 up no dn no up no 14:1/18:2-PG+blood 16:1-LPC+blood 0 0 0.541196581 serum_phospholipids serum_phospholipids 0.00259 0.0241 no up up no up no 16:0-LPC+blood 16:1-LPC+blood 0 0 0.485811966 serum_phospholipids serum_phospholipids 0.00456 0.0241 up up no no up no 16:0-LPE+blood 16:1-LPC+blood 0 0.600490196 0 serum_phospholipids serum_phospholipids 0.0711 0.0241 up up no no up no 16:0/16:0-PI+blood 16:1-LPC+blood 0 0 0.555555556 serum_phospholipids serum_phospholipids 0.358 0.0241 no no no no up no 16:0/16:1-PC+blood 16:1-LPC+blood 0 0 0.608888889 serum_phospholipids serum_phospholipids 0.00283 0.0241 up up no no up no 16:0/16:1-PI+blood 16:1-LPC+blood 0 0 0.653333333 serum_phospholipids serum_phospholipids 0.262 0.0241 no no no no up no 16:0/18:2-PI+blood 16:1-LPC+blood 0 0 0.516581197 serum_phospholipids serum_phospholipids 0.269 0.0241 no no no no up no 16:0/18:3-PC+blood 16:1-LPC+blood 0 0 0.537094017 serum_phospholipids serum_phospholipids 0.00216 0.0241 no up up no up no 16:0/20:4-PI+blood 16:1-LPC+blood 0 0 0.550769231 serum_phospholipids serum_phospholipids 0.558 0.0241 no no no no up no 16:0+blood 16:1-LPC+blood 0 0 0.673162393 yes serum_fattyacid serum_phospholipids 0.00876 0.0241 up no no no up no 16:1+blood 16:1-LPC+blood 0 0 0.42017094 yes serum_fattyacid serum_phospholipids 0.0186 0.0241 no no dn no up no 14:0-LPC+blood 16:1/16:0-PC+blood 0 -0.575980392 -0.48991453 serum_phospholipids serum_phospholipids 0.00689 0.0215 up up no no up up 14:0/18:0-PC+blood 16:1/16:0-PC+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.00289 0.0215 up up no no up up 14:0/18:2-PC+blood 16:1/16:0-PC+blood 0 0 -0.527521368 serum_phospholipids serum_phospholipids 0.102 0.0215 no up no no up up 14:0/20:4-PC+blood 16:1/16:0-PC+blood 0 0 -0.612991453 serum_phospholipids serum_phospholipids 0.486 0.0215 no no no no up up 14:1/18:2-PG+blood 16:1/16:0-PC+blood 0 0 -0.579487179 serum_phospholipids serum_phospholipids 0.00259 0.0215 no up up no up up 16:0-LPC+blood 16:1/16:0-PC+blood 0 0 -0.505641026 serum_phospholipids serum_phospholipids 0.00456 0.0215 up up no no up up 16:0/14:0-PC+blood 16:1/16:0-PC+blood 0.720300752 0 0.693675214 serum_phospholipids serum_phospholipids 0.0206 0.0215 no up up no up up 16:0/16:0-PC+blood 16:1/16:0-PC+blood 0.633082707 0 0.625299145 serum_phospholipids serum_phospholipids 0.00079 0.0215 no up up no up up 16:0/16:0-PI+blood 16:1/16:0-PC+blood 0 -0.590686275 0 serum_phospholipids serum_phospholipids 0.358 0.0215 no no no no up up 16:0/16:1-PI+blood 16:1/16:0-PC+blood -0.542857143 -0.495098039 0 serum_phospholipids serum_phospholipids 0.262 0.0215 no no no no up up 16:0/18:0-PC+blood 16:1/16:0-PC+blood 0.470676692 0 0 serum_phospholipids serum_phospholipids 0.521 0.0215 no no no no up up 16:0/18:1-PC+blood 16:1/16:0-PC+blood 0.828571429 0.700980392 0.541880342 serum_phospholipids serum_phospholipids 6.15E-07 0.0215 up up up no up up 16:0/18:2-PC+blood 16:1/16:0-PC+blood 0.816541353 0.617647059 0.816752137 serum_phospholipids serum_phospholipids 3.24E-06 0.0215 no up up no up up 16:0/20:3-PC+blood 16:1/16:0-PC+blood 0.581954887 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.0215 no up up no up up 16:0/20:4-PC+blood 16:1/16:0-PC+blood 0.593984962 0.585784314 0.478974359 serum_phospholipids serum_phospholipids 0.0262 0.0215 no up no no up up 16:0/20:4-PI+blood 16:1/16:0-PC+blood -0.460150376 0 0 serum_phospholipids serum_phospholipids 0.558 0.0215 no no no no up up 16:0/22:0-PE+blood 16:1/16:0-PC+blood 0 0.544117647 0 serum_phospholipids serum_phospholipids 0.00839 0.0215 dn no up no up up 16:0/22:6-PC+blood 16:1/16:0-PC+blood 0.711278195 0.784313725 0.741538462 serum_phospholipids serum_phospholipids 4.53E-05 0.0215 no up up no up up Alzheimer disease 16:1/16:0-PC+blood 0 0 -0.465384615 kegg serum_phospholipids NA 0.0215 no no no no up up Amyotrophic lateral sclerosis 16:1/16:0-PC+blood 0 0 -0.510769231 kegg serum_phospholipids NA 0.0215 no no no no up up Calcium signaling pathway 16:1/16:0-PC+blood 0 0 -0.413846154 kegg serum_phospholipids NA 0.0215 no up up no up up Carbon metabolism 16:1/16:0-PC+blood 0 0 0.473846154 kegg serum_phospholipids NA 0.0215 no no no no up up Cardiac muscle contraction 16:1/16:0-PC+blood 0 0 -0.490769231 kegg serum_phospholipids NA 0.0215 no no up no up up Central carbon metabolism in cancer 16:1/16:0-PC+blood 0 -0.570588235 0 kegg serum_phospholipids NA 0.0215 no no no no up up Colorectal cancer 16:1/16:0-PC+blood 0 -0.526470588 0 kegg serum_phospholipids NA 0.0215 no no no no up up Cytokine-cytokine receptor interaction 16:1/16:0-PC+blood 0 0.523529412 0 kegg serum_phospholipids NA 0.0215 no no no no up up Diabetic cardiomyopathy 16:1/16:0-PC+blood 0 0 -0.435384615 kegg serum_phospholipids NA 0.0215 no no no no up up Huntington disease 16:1/16:0-PC+blood 0 0 -0.471538462 kegg serum_phospholipids NA 0.0215 no no no no up up IL-17 signaling pathway 16:1/16:0-PC+blood 0 0 0.446923077 kegg serum_phospholipids NA 0.0215 no no no no up up L-Tryptophan+stool 16:1/16:0-PC+blood 0 0 0.452631579 stool_cometabolism serum_phospholipids 0.557 0.0215 no no no no up up Lysosome 16:1/16:0-PC+blood 0 0 0.444615385 kegg serum_phospholipids NA 0.0215 no no no no up up Non-alcoholic fatty liver disease 16:1/16:0-PC+blood 0 0 -0.535384615 kegg serum_phospholipids NA 0.0215 no no no no up up Oxidative phosphorylation 16:1/16:0-PC+blood 0 0 -0.416923077 kegg serum_phospholipids NA 0.0215 no no no no up up Prevotella 16:1/16:0-PC+blood -0.521065478 0 0 acetate-producing Genus serum_phospholipids 0.287 0.0215 no no no no up up Prion disease 16:1/16:0-PC+blood 0 0 -0.450769231 kegg serum_phospholipids NA 0.0215 no no no no up up Renal cell carcinoma 16:1/16:0-PC+blood 0 -0.611764706 0 kegg serum_phospholipids NA 0.0215 no no no no up up Thyroid hormone signaling pathway 16:1/16:0-PC+blood 0 0 -0.41 kegg serum_phospholipids NA 0.0215 no no no no up up 14:0-LPC+blood 16:1/16:1-PC+blood -0.45112782 0 0 serum_phospholipids serum_phospholipids 0.00689 0.0177 up up no no no up 16:0/14:0-PC+blood 16:1/16:1-PC+blood 0.648120301 0 0.574700855 serum_phospholipids serum_phospholipids 0.0206 0.0177 no up up no no up 16:0/16:0-PC+blood 16:1/16:1-PC+blood 0.676691729 0 0.597264957 serum_phospholipids serum_phospholipids 0.00079 0.0177 no up up no no up 16:0/16:1-PI+blood 16:1/16:1-PC+blood -0.637593985 0 0 serum_phospholipids serum_phospholipids 0.262 0.0177 no no no no no up 16:0/18:0-PC+blood 16:1/16:1-PC+blood 0.577443609 0 0 serum_phospholipids serum_phospholipids 0.521 0.0177 no no no no no up 16:0/18:1-PC+blood 16:1/16:1-PC+blood 0.786466165 0 0.558974359 serum_phospholipids serum_phospholipids 6.15E-07 0.0177 up up up no no up 16:0/18:2-PC+blood 16:1/16:1-PC+blood 0.583458647 0 0.576752137 serum_phospholipids serum_phospholipids 3.24E-06 0.0177 no up up no no up 16:0/18:2-PI+blood 16:1/16:1-PC+blood -0.535338346 0 0 serum_phospholipids serum_phospholipids 0.269 0.0177 no no no no no up 16:0/20:3-PC+blood 16:1/16:1-PC+blood 0.481203008 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.0177 no up up no no up 16:0/20:4-PC+blood 16:1/16:1-PC+blood 0.616541353 0.485294118 0 serum_phospholipids serum_phospholipids 0.0262 0.0177 no up no no no up 16:0/20:4-PI+blood 16:1/16:1-PC+blood -0.467669173 0 0 serum_phospholipids serum_phospholipids 0.558 0.0177 no no no no no up 16:0/20:5-PG+blood 16:1/16:1-PC+blood 0.485714286 0 0 serum_phospholipids serum_phospholipids 0.00656 0.0177 no up no no no up 16:0/22:6-PC+blood 16:1/16:1-PC+blood 0.590977444 0.588235294 0.472136752 serum_phospholipids serum_phospholipids 4.53E-05 0.0177 no up up no no up 16:1/16:0-PC+blood 16:1/16:1-PC+blood 0.867669173 0.68627451 0.803760684 serum_phospholipids serum_phospholipids 0.0215 0.0177 no up up no no up 16:1+blood 16:1/16:1-PC+blood 0 0 0.44 yes serum_fattyacid serum_phospholipids 0.0186 0.0177 no no dn no no up Arginine and proline metabolism 16:1/16:1-PC+blood 0 0 0.474615385 kegg serum_phospholipids NA 0.0177 no up no no no up Axon guidance 16:1/16:1-PC+blood 0 -0.597058824 0 kegg serum_phospholipids NA 0.0177 no up up no no up Bacteroides 16:1/16:1-PC+blood 0 0.517156863 0 LPS-producing Genus serum_phospholipids 0.000267 0.0177 dn dn up no no up Butyric acid+stool 16:1/16:1-PC+blood 0 0 -0.493233083 yes stool_scfa serum_phospholipids 0.102 0.0177 dn no no no no up Calcium signaling pathway 16:1/16:1-PC+blood 0 -0.502941176 0 kegg serum_phospholipids NA 0.0177 no up up no no up Cell cycle 16:1/16:1-PC+blood 0 0 -0.436923077 kegg serum_phospholipids NA 0.0177 no no no no no up Colorectal cancer 16:1/16:1-PC+blood 0 -0.517647059 0 kegg serum_phospholipids NA 0.0177 no no no no no up Cytokine-cytokine receptor interaction 16:1/16:1-PC+blood 0 0.655882353 0 kegg serum_phospholipids NA 0.0177 no no no no no up Faecalibacterium 16:1/16:1-PC+blood 0 0 -0.401778088 butyrate-producing Genus serum_phospholipids 0.0039 0.0177 no dn dn no no up Ferroptosis 16:1/16:1-PC+blood 0 0 0.415384615 kegg serum_phospholipids NA 0.0177 no no no no no up GABAergic synapse 16:1/16:1-PC+blood 0 0 0.54 kegg serum_phospholipids NA 0.0177 no up up no no up Gastric cancer 16:1/16:1-PC+blood 0 -0.552941176 0 kegg serum_phospholipids NA 0.0177 no no no no no up IL-17 signaling pathway 16:1/16:1-PC+blood 0 0 0.472307692 kegg serum_phospholipids NA 0.0177 no no no no no up Malaria 16:1/16:1-PC+blood 0 0 0.457692308 kegg serum_phospholipids NA 0.0177 no no no no no up Mitophagy - animal 16:1/16:1-PC+blood -0.49122807 0 0 kegg serum_phospholipids NA 0.0177 no no no no no up Prevotella 16:1/16:1-PC+blood -0.592351309 0 0 acetate-producing Genus serum_phospholipids 0.287 0.0177 no no no no no up Proteoglycans in cancer 16:1/16:1-PC+blood -0.489473684 0 0 kegg serum_phospholipids NA 0.0177 no no no no no up Signaling pathways regulating pluripotency of stem cells 16:1/16:1-PC+blood 0 -0.582352941 0 kegg serum_phospholipids NA 0.0177 no no no no no up Slackia 16:1/16:1-PC+blood 0 0 -0.44367365 Genus serum_phospholipids 0.94 0.0177 no no no no no up Systemic lupus erythematosus 16:1/16:1-PC+blood 0.50877193 0 0 kegg serum_phospholipids NA 0.0177 no no no no no up Tuberculosis 16:1/16:1-PC+blood 0.468421053 0 0 kegg serum_phospholipids NA 0.0177 no no dn no no up Ubiquitin mediated proteolysis 16:1/16:1-PC+blood -0.463157895 0 0 kegg serum_phospholipids NA 0.0177 no no no no no up 11-HETE+blood 16:1/18:1-PG+blood 0 0.587916498 0 serum_ARA serum_phospholipids 0.464 3.21E-05 no no no no up up 12-ketoDCA+blood 16:1/18:1-PG+blood 0 -0.490684079 0 serum_bileacids serum_phospholipids 0.517 3.21E-05 no no no no up up 13-HODE+blood 16:1/18:1-PG+blood 0 0 -0.444786325 serum_ARA serum_phospholipids 0.32 3.21E-05 no no no no up up 14:0-LPC+blood 16:1/18:1-PG+blood -0.669172932 0 0 serum_phospholipids serum_phospholipids 0.00689 3.21E-05 up up no no up up 14:0+blood 16:1/18:1-PG+blood -0.461654135 0 0 yes serum_fattyacid serum_phospholipids 0.00572 3.21E-05 up no dn no up up 14:1/18:2-PG+blood 16:1/18:1-PG+blood -0.473684211 0 0 serum_phospholipids serum_phospholipids 0.00259 3.21E-05 no up up no up up 16:0/16:1-PC+blood 16:1/18:1-PG+blood 0 0.514705882 0 serum_phospholipids serum_phospholipids 0.00283 3.21E-05 up up no no up up 16:0/16:1-PI+blood 16:1/18:1-PG+blood 0 0.634803922 0 serum_phospholipids serum_phospholipids 0.262 3.21E-05 no no no no up up 16:0/18:0-PS+blood 16:1/18:1-PG+blood 0 0 0.675213675 serum_phospholipids serum_phospholipids 0.377 3.21E-05 no no no no up up 16:0/18:1-PC+blood 16:1/18:1-PG+blood 0.571428571 0 0 serum_phospholipids serum_phospholipids 6.15E-07 3.21E-05 up up up no up up 16:0/18:1-PE+blood 16:1/18:1-PG+blood 0 0.487745098 0 serum_phospholipids serum_phospholipids 0.000107 3.21E-05 up up no no up up 16:0/18:2-PI+blood 16:1/18:1-PG+blood -0.587969925 0 0 serum_phospholipids serum_phospholipids 0.269 3.21E-05 no no no no up up 16:0/20:4-PI+blood 16:1/18:1-PG+blood -0.494736842 0 0 serum_phospholipids serum_phospholipids 0.558 3.21E-05 no no no no up up 16:0/20:5-PG+blood 16:1/18:1-PG+blood 0.729323308 0 0.56991453 serum_phospholipids serum_phospholipids 0.00656 3.21E-05 no up no no up up 16:1-LPC+blood 16:1/18:1-PG+blood 0 0 0.473504274 serum_phospholipids serum_phospholipids 0.0241 3.21E-05 no up no no up up 16:1/16:1-PC+blood 16:1/18:1-PG+blood 0.589473684 0 0 serum_phospholipids serum_phospholipids 0.0177 3.21E-05 no no up no up up 16:1+blood 16:1/18:1-PG+blood 0 0.514705882 0 yes serum_fattyacid serum_phospholipids 0.0186 3.21E-05 no no dn no up up 13-HODE+blood 16:1/18:2-PG+blood 0.509774436 0 -0.45982906 serum_ARA serum_phospholipids 0.32 1.40E-08 no no no no up up 16:0-LPE+blood 16:1/18:2-PG+blood -0.532330827 0 0 serum_phospholipids serum_phospholipids 0.0711 1.40E-08 up up no no up up 16:0/14:0-PC+blood 16:1/18:2-PG+blood 0.472180451 0 0 serum_phospholipids serum_phospholipids 0.0206 1.40E-08 no up up no up up 16:0/16:1-PI+blood 16:1/18:2-PG+blood -0.578947368 0 0 serum_phospholipids serum_phospholipids 0.262 1.40E-08 no no no no up up 16:0/18:0-PS+blood 16:1/18:2-PG+blood 0 0 0.427008547 serum_phospholipids serum_phospholipids 0.377 1.40E-08 no no no no up up 16:0/18:1-PC+blood 16:1/18:2-PG+blood 0.610526316 0 0 serum_phospholipids serum_phospholipids 6.15E-07 1.40E-08 up up up no up up 16:0/18:1-PE+blood 16:1/18:2-PG+blood -0.455639098 0 0 serum_phospholipids serum_phospholipids 0.000107 1.40E-08 up up no no up up 16:0/18:2-PC+blood 16:1/18:2-PG+blood 0.584962406 0 0 serum_phospholipids serum_phospholipids 3.24E-06 1.40E-08 no up up no up up 16:0/18:2-PI+blood 16:1/18:2-PG+blood -0.445112782 0 0 serum_phospholipids serum_phospholipids 0.269 1.40E-08 no no no no up up 16:0/20:3-PC+blood 16:1/18:2-PG+blood 0.633082707 0 0 serum_phospholipids serum_phospholipids 5.43E-06 1.40E-08 no up up no up up 16:0/20:4-PC+blood 16:1/18:2-PG+blood 0.496240602 0 0 serum_phospholipids serum_phospholipids 0.0262 1.40E-08 no up no no up up 16:0/20:4-PI+blood 16:1/18:2-PG+blood -0.520300752 0 0 serum_phospholipids serum_phospholipids 0.558 1.40E-08 no no no no up up 16:0/20:5-PG+blood 16:1/18:2-PG+blood 0.62556391 0 0.695726496 serum_phospholipids serum_phospholipids 0.00656 1.40E-08 no up no no up up 16:0+blood 16:1/18:2-PG+blood 0 0.549019608 0 yes serum_fattyacid serum_phospholipids 0.00876 1.40E-08 up no no no up up 16:1/16:0-PC+blood 16:1/18:2-PG+blood 0.544360902 0 0 serum_phospholipids serum_phospholipids 0.0215 1.40E-08 no up up no up up 16:1/16:1-PC+blood 16:1/18:2-PG+blood 0.596992481 0 0 serum_phospholipids serum_phospholipids 0.0177 1.40E-08 no no up no up up 16:1/18:1-PG+blood 16:1/18:2-PG+blood 0.77593985 0.600490196 0.736752137 serum_phospholipids serum_phospholipids 3.21E-05 1.40E-08 no up up no up up Akkermansia 16:1/18:2-PG+blood 0 0 -0.459096253 acetate-producing Genus serum_phospholipids 0.23 1.40E-08 no no no no up up Allograft rejection 16:1/18:2-PG+blood 0 0.544117647 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Amoebiasis 16:1/18:2-PG+blood 0 0.529411765 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Apelin signaling pathway 16:1/18:2-PG+blood 0 -0.508823529 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Apoptosis 16:1/18:2-PG+blood 0 0.720588235 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Autoimmune thyroid disease 16:1/18:2-PG+blood 0 0.544117647 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Bacteroides 16:1/18:2-PG+blood 0 -0.553921569 0 LPS-producing Genus serum_phospholipids 0.000267 1.40E-08 dn dn up no up up Biosynthesis of cofactors 16:1/18:2-PG+blood 0 -0.697058824 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up C-type lectin receptor signaling pathway 16:1/18:2-PG+blood 0 0.541176471 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Cell adhesion molecules 16:1/18:2-PG+blood 0 0.532352941 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Cell cycle 16:1/18:2-PG+blood 0 -0.520588235 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Cellular senescence 16:1/18:2-PG+blood 0 0.597058824 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Chagas disease 16:1/18:2-PG+blood 0 0.529411765 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up EGFR tyrosine kinase inhibitor resistance 16:1/18:2-PG+blood 0 -0.5 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Endocytosis 16:1/18:2-PG+blood 0 0.561764706 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Epithelial cell signaling in Helicobacter pylori infection 16:1/18:2-PG+blood 0 0.505882353 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Fc epsilon RI signaling pathway 16:1/18:2-PG+blood 0 0.511764706 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up GCDCA+stool 16:1/18:2-PG+blood 0 0.681818182 0 yes stool_bileacids serum_phospholipids 0.0471 1.40E-08 no dn no no up up "Glycine, serine and threonine metabolism" 16:1/18:2-PG+blood 0 -0.623529412 0 kegg serum_phospholipids NA 1.40E-08 no up no no up up Graft-versus-host disease 16:1/18:2-PG+blood 0 0.544117647 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Human papillomavirus infection 16:1/18:2-PG+blood 0 0.520588235 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up IL-17 signaling pathway 16:1/18:2-PG+blood 0 0.529411765 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Influenza A 16:1/18:2-PG+blood 0 0.514705882 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up mTOR signaling pathway 16:1/18:2-PG+blood 0 -0.505882353 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Natural killer cell mediated cytotoxicity 16:1/18:2-PG+blood 0 0.579411765 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up NOD-like receptor signaling pathway 16:1/18:2-PG+blood 0 0 -0.449230769 kegg serum_phospholipids NA 1.40E-08 no no no no up up Osteoclast differentiation 16:1/18:2-PG+blood 0 0.605882353 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Parabacteroides 16:1/18:2-PG+blood 0.466165414 0 0 Genus serum_phospholipids 4.19E-05 1.40E-08 no up up no up up Pertussis 16:1/18:2-PG+blood 0 0.517647059 0 kegg serum_phospholipids NA 1.40E-08 no no dn no up up Primary immunodeficiency 16:1/18:2-PG+blood 0 -0.517647059 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Prolactin signaling pathway 16:1/18:2-PG+blood 0 0.567647059 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Protein processing in endoplasmic reticulum 16:1/18:2-PG+blood 0 -0.511764706 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Purine metabolism 16:1/18:2-PG+blood 0 -0.511764706 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Ras signaling pathway 16:1/18:2-PG+blood 0 -0.638235294 0.417692308 yes kegg serum_phospholipids NA 1.40E-08 no up up no up up RNA degradation 16:1/18:2-PG+blood 0 -0.535294118 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up RNA transport 16:1/18:2-PG+blood 0 -0.502941176 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Sphingolipid signaling pathway 16:1/18:2-PG+blood 0 0.508823529 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Toll-like receptor signaling pathway 16:1/18:2-PG+blood 0 0.552941176 0 yes kegg serum_phospholipids NA 1.40E-08 no no no no up up Type I diabetes mellitus 16:1/18:2-PG+blood 0 0.544117647 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Viral carcinogenesis 16:1/18:2-PG+blood 0 0.552941176 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Viral myocarditis 16:1/18:2-PG+blood 0 0.567647059 0 kegg serum_phospholipids NA 1.40E-08 no no no no up up Wnt signaling pathway 16:1/18:2-PG+blood 0 -0.547058824 0.41 kegg serum_phospholipids NA 1.40E-08 no no no no up up 11-HETE+blood 16:1+blood 0 0.490408396 0 yes serum_ARA serum_fattyacid 0.464 0.0186 no no no no no dn 12-ketoDCA+blood 16:1+blood 0 -0.579599987 0 yes serum_bileacids serum_fattyacid 0.517 0.0186 no no no no no dn 13-HODE+blood 16:1+blood 0.612030075 0 0 yes serum_ARA serum_fattyacid 0.32 0.0186 no no no no no dn 14:0/18:0-PC+blood 16:1+blood 0 0 0.629401709 yes serum_phospholipids serum_fattyacid 0.00289 0.0186 up up no no no dn 14:0+blood 16:1+blood 0.466165414 0 0.404444444 yes yes serum_fattyacid serum_fattyacid 0.00572 0.0186 up no dn no no dn 16:0-LPE+blood 16:1+blood 0 0.556372549 0 yes serum_phospholipids serum_fattyacid 0.0711 0.0186 up up no no no dn 16:0/16:1-PC+blood 16:1+blood 0 0 0.63008547 yes serum_phospholipids serum_fattyacid 0.00283 0.0186 up up no no no dn 16:0/16:1-PI+blood 16:1+blood 0 0 0.536410256 yes serum_phospholipids serum_fattyacid 0.262 0.0186 no no no no no dn 16:0/18:0-PC+blood 16:1+blood 0 0 -0.40991453 yes serum_phospholipids serum_fattyacid 0.521 0.0186 no no no no no dn 16:0/18:0-PS+blood 16:1+blood 0 0.595588235 0 yes serum_phospholipids serum_fattyacid 0.377 0.0186 no no no no no dn 16:0/18:1-PC+blood 16:1+blood 0 0 0.51042735 yes serum_phospholipids serum_fattyacid 6.15E-07 0.0186 up up up no no dn 16:0/18:1-PE+blood 16:1+blood 0 0.507352941 0.495384615 yes serum_phospholipids serum_fattyacid 0.000107 0.0186 up up no no no dn 16:0/18:3-PC+blood 16:1+blood 0 -0.487745098 0 yes serum_phospholipids serum_fattyacid 0.00216 0.0186 no up up no no dn 16:0/20:4-PE+blood 16:1+blood 0 0.642156863 0.42974359 yes serum_phospholipids serum_fattyacid 0.00139 0.0186 up up no no no dn 16:0/22:0-PE+blood 16:1+blood 0 0 -0.538461538 yes serum_phospholipids serum_fattyacid 0.00839 0.0186 dn no up no no dn 16:0/22:6-PE+blood 16:1+blood 0 0.620098039 0.418803419 yes serum_phospholipids serum_fattyacid 0.000934 0.0186 up up no no no dn 16:0+blood 16:1+blood 0.681203008 0 0.593846154 yes yes serum_fattyacid serum_fattyacid 0.00876 0.0186 up no no no no dn AGE-RAGE signaling pathway in diabetic complications 16:1+blood 0.533333333 0 0 yes kegg serum_fattyacid NA 0.0186 no no no no no dn AMPK signaling pathway 16:1+blood -0.510526316 0 0 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Antigen processing and presentation 16:1+blood 0 0 0.611538462 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Arginine and proline metabolism 16:1+blood 0 0 0.497692308 yes kegg serum_fattyacid NA 0.0186 no up no no no dn Biosynthesis of cofactors 16:1+blood -0.568421053 0 0 yes kegg serum_fattyacid NA 0.0186 no no no no no dn C-type lectin receptor signaling pathway 16:1+blood 0 0 0.41 yes kegg serum_fattyacid NA 0.0186 no no no no no dn cGMP-PKG signaling pathway 16:1+blood 0.58245614 0 0 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Cholinergic synapse 16:1+blood 0.529824561 0 0 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Cushing syndrome 16:1+blood -0.459649123 0 0 yes kegg serum_fattyacid NA 0.0186 no no up no no dn Cytosolic DNA-sensing pathway 16:1+blood 0 0 0.507692308 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Epithelial cell signaling in Helicobacter pylori infection 16:1+blood 0 0 0.486153846 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Epstein-Barr virus infection 16:1+blood 0 0 0.650769231 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Glioma 16:1+blood 0.596491228 0 0 yes kegg serum_fattyacid NA 0.0186 no no no no no dn "Glycine, serine and threonine metabolism" 16:1+blood -0.526315789 0 0 yes kegg serum_fattyacid NA 0.0186 no up no no no dn HCA+stool 16:1+blood 0.604395604 0 0 yes stool_bileacids serum_fattyacid 0.155 0.0186 no no no no no dn Herpes simplex virus 1 infection 16:1+blood 0 0 0.646153846 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Human cytomegalovirus infection 16:1+blood 0 0 0.638461538 yes kegg serum_fattyacid NA 0.0186 no no dn no no dn Human immunodeficiency virus 1 infection 16:1+blood 0 0 0.675384615 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Human T-cell leukemia virus 1 infection 16:1+blood 0 0 0.635384615 yes kegg serum_fattyacid NA 0.0186 no no no no no dn L-Tyrosine+stool 16:1+blood 0 0 -0.50075188 yes stool_cometabolism serum_fattyacid 0.44 0.0186 no no no no no dn Legionellosis 16:1+blood 0 -0.523529412 0 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Leishmaniasis 16:1+blood 0 -0.508823529 0 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Lipid and atherosclerosis 16:1+blood 0.666666667 0 0.480769231 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Long-term potentiation 16:1+blood 0.547368421 0 0 yes kegg serum_fattyacid NA 0.0186 no no up no no dn Measles 16:1+blood 0 -0.511764706 0.430769231 yes kegg serum_fattyacid NA 0.0186 no no no no no dn NOD-like receptor signaling pathway 16:1+blood 0.507017544 0 0 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Olfactory transduction 16:1+blood 0.512280702 0 0 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Peroxisome 16:1+blood 0.461403509 0 0 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Pertussis 16:1+blood 0.536842105 0 0 yes kegg serum_fattyacid NA 0.0186 no no dn no no dn Porphyrin and chlorophyll metabolism 16:1+blood -0.522807018 0 0 yes kegg serum_fattyacid NA 0.0186 no no no no no dn PPAR signaling pathway 16:1+blood 0 0 0.48 yes kegg serum_fattyacid NA 0.0186 no no no no no dn TNF signaling pathway 16:1+blood 0 0 0.47 yes kegg serum_fattyacid NA 0.0186 no no no no no dn Toll-like receptor signaling pathway 16:1+blood 0 0 0.453076923 yes yes kegg serum_fattyacid NA 0.0186 no no no no no dn VEGF signaling pathway 16:1+blood 0.461403509 0 0 yes kegg serum_fattyacid NA 0.0186 no no no no no dn 12-HEPE+blood 17-HDOHE+blood 0 0.548529813 0 serum_ARA serum_ARA 0.312 0.62 no no no no no no Butyricicoccus 17-HDOHE+blood 0 0 0.426699929 butyrate-producing Genus serum_ARA 0.852 0.62 no no no no no no Pyramidobacter 17-HDOHE+blood 0 0 -0.48441412 Genus serum_ARA 0.45 0.62 no no no no no no 11-HETE+blood 18:0-LPA+blood -0.476087514 0 0 serum_ARA serum_phospholipids 0.464 0.0725 no no no no dn no 15-HETE+blood 18:0-LPA+blood 0 0 -0.480800243 serum_ARA serum_phospholipids 0.819 0.0725 no no no no dn no 16:0-LPC+blood 18:0-LPA+blood 0.445112782 0 0.515213675 serum_phospholipids serum_phospholipids 0.00456 0.0725 up up no no dn no 16:0/14:0-PC+blood 18:0-LPA+blood 0 0 -0.446153846 serum_phospholipids serum_phospholipids 0.0206 0.0725 no up up no dn no 16:0/16:0-PC+blood 18:0-LPA+blood 0 0 -0.417435897 serum_phospholipids serum_phospholipids 0.00079 0.0725 no up up no dn no 16:0/20:4-PC+blood 18:0-LPA+blood 0 0 -0.419487179 serum_phospholipids serum_phospholipids 0.0262 0.0725 no up no no dn no 16:0/20:4-PE+blood 18:0-LPA+blood 0.532330827 0 0 serum_phospholipids serum_phospholipids 0.00139 0.0725 up up no no dn no 16:1-LPC+blood 18:0-LPA+blood 0 0 0.513846154 serum_phospholipids serum_phospholipids 0.0241 0.0725 no up no no dn no 16:1/16:0-PC+blood 18:0-LPA+blood 0 0 -0.538461538 serum_phospholipids serum_phospholipids 0.0215 0.0725 no up up no dn no 16:1/16:1-PC+blood 18:0-LPA+blood 0 0 -0.506324786 serum_phospholipids serum_phospholipids 0.0177 0.0725 no no up no dn no Alzheimer disease 18:0-LPA+blood 0 0 0.442307692 kegg serum_phospholipids NA 0.0725 no no no no dn no Cardiac muscle contraction 18:0-LPA+blood 0 0 0.405384615 kegg serum_phospholipids NA 0.0725 no no up no dn no CDCA+stool 18:0-LPA+blood 0 0 0.518796992 stool_bileacids serum_phospholipids 0.663 0.0725 no no no no dn no Glycolysis / Gluconeogenesis 18:0-LPA+blood 0 0 -0.418461538 kegg serum_phospholipids NA 0.0725 no no no no dn no HCA+stool 18:0-LPA+blood 0 0 0.473684211 stool_bileacids serum_phospholipids 0.155 0.0725 no no no no dn no HDCA+stool 18:0-LPA+blood 0 0 -0.445112782 stool_bileacids serum_phospholipids 0.176 0.0725 no no no no dn no Huntington disease 18:0-LPA+blood 0 0 0.452307692 kegg serum_phospholipids NA 0.0725 no no no no dn no L-Tryptophan+stool 18:0-LPA+blood 0 0 -0.55037594 stool_cometabolism serum_phospholipids 0.557 0.0725 no no no no dn no Phenylacetic acid+stool 18:0-LPA+blood 0 0 -0.487218045 stool_cometabolism serum_phospholipids 0.785 0.0725 no no no no dn no Prion disease 18:0-LPA+blood 0 0 0.420769231 kegg serum_phospholipids NA 0.0725 no no no no dn no 16:0-LPC+blood 18:0-LPC+blood 0.542857143 0 0.47008547 serum_phospholipids serum_phospholipids 0.00456 0.554 up up no no no no 16:0/16:0-PC+blood 18:0-LPC+blood 0 -0.625 0 serum_phospholipids serum_phospholipids 0.00079 0.554 no up up no no no 16:0/16:1-PC+blood 18:0-LPC+blood -0.49924812 0 0 serum_phospholipids serum_phospholipids 0.00283 0.554 up up no no no no 16:0/18:0-PC+blood 18:0-LPC+blood 0 0 0.671794872 serum_phospholipids serum_phospholipids 0.521 0.554 no no no no no no 16:0/18:1-PC+blood 18:0-LPC+blood 0 -0.595588235 0 serum_phospholipids serum_phospholipids 6.15E-07 0.554 up up up no no no 16:0/18:2-PC+blood 18:0-LPC+blood 0 -0.644607843 0 serum_phospholipids serum_phospholipids 3.24E-06 0.554 no up up no no no 16:0+blood 18:0-LPC+blood 0 -0.541666667 0 yes serum_fattyacid serum_phospholipids 0.00876 0.554 up no no no no no Adipocytokine signaling pathway 18:0-LPC+blood -0.484210526 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Adlercreutzia 18:0-LPC+blood 0 0 0.42154647 Genus serum_phospholipids 0.548 0.554 no no no no no no Adrenergic signaling in cardiomyocytes 18:0-LPC+blood 0 0.517647059 0 kegg serum_phospholipids NA 0.554 no no up no no no Aldosterone synthesis and secretion 18:0-LPC+blood 0.529824561 0.573529412 0 kegg serum_phospholipids NA 0.554 no up up no no no Alistipes 18:0-LPC+blood 0 0.587369822 0 Genus serum_phospholipids 0.0114 0.554 no up no no no no Allograft rejection 18:0-LPC+blood -0.592982456 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Amphetamine addiction 18:0-LPC+blood 0.619298246 0 0 kegg serum_phospholipids NA 0.554 no no no no no no AMPK signaling pathway 18:0-LPC+blood 0 0.576470588 0 kegg serum_phospholipids NA 0.554 no no no no no no Antigen processing and presentation 18:0-LPC+blood 0 0 -0.426153846 kegg serum_phospholipids NA 0.554 no no no no no no Apoptosis 18:0-LPC+blood -0.571929825 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Autoimmune thyroid disease 18:0-LPC+blood -0.592982456 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Butyricimonas 18:0-LPC+blood 0.618914319 0 0 butyrate-producing Genus serum_phospholipids 0.17 0.554 no no no no no no Calcium signaling pathway 18:0-LPC+blood 0 0.632352941 0 kegg serum_phospholipids NA 0.554 no up up no no no Cell adhesion molecules 18:0-LPC+blood -0.573684211 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Cell cycle 18:0-LPC+blood 0.559649123 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Cellular senescence 18:0-LPC+blood -0.547368421 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Central carbon metabolism in cancer 18:0-LPC+blood 0 0.647058824 0 kegg serum_phospholipids NA 0.554 no no no no no no Chemical carcinogenesis - receptor activation 18:0-LPC+blood 0.484210526 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Circadian entrainment 18:0-LPC+blood 0.459649123 0 0 kegg serum_phospholipids NA 0.554 no up up no no no Cushing syndrome 18:0-LPC+blood 0.473684211 0.544117647 0 kegg serum_phospholipids NA 0.554 no no up no no no Cytosolic DNA-sensing pathway 18:0-LPC+blood -0.533333333 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Dorea 18:0-LPC+blood -0.565413534 0 0 Genus serum_phospholipids 0.00362 0.554 up no dn no no no Endocrine resistance 18:0-LPC+blood 0 0.517647059 0 kegg serum_phospholipids NA 0.554 no no no no no no Endocytosis 18:0-LPC+blood -0.538596491 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Epithelial cell signaling in Helicobacter pylori infection 18:0-LPC+blood -0.559649123 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Estrogen signaling pathway 18:0-LPC+blood 0.496491228 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Glucagon signaling pathway 18:0-LPC+blood 0.642105263 0.564705882 0 kegg serum_phospholipids NA 0.554 no no no no no no "Glycine, serine and threonine metabolism" 18:0-LPC+blood 0 0.5 0 kegg serum_phospholipids NA 0.554 no up no no no no GnRH signaling pathway 18:0-LPC+blood 0.49122807 0.523529412 0 kegg serum_phospholipids NA 0.554 no no no no no no Graft-versus-host disease 18:0-LPC+blood -0.592982456 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Human papillomavirus infection 18:0-LPC+blood -0.545614035 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Inflammatory mediator regulation of TRP channels 18:0-LPC+blood 0.584210526 0.602941176 0 kegg serum_phospholipids NA 0.554 no no no no no no Influenza A 18:0-LPC+blood -0.542105263 -0.535294118 0 kegg serum_phospholipids NA 0.554 no no no no no no Insulin resistance 18:0-LPC+blood 0 0 0.496923077 kegg serum_phospholipids NA 0.554 no no no no no no Long-term potentiation 18:0-LPC+blood 0.643859649 0 0 kegg serum_phospholipids NA 0.554 no no up no no no Longevity regulating pathway - multiple species 18:0-LPC+blood 0 0 -0.426153846 kegg serum_phospholipids NA 0.554 no no no no no no Melanogenesis 18:0-LPC+blood 0.505263158 0.608823529 0 kegg serum_phospholipids NA 0.554 no no no no no no Methanobrevibacter 18:0-LPC+blood 0 0 0.49421965 Genus serum_phospholipids 0.629 0.554 no no no no no no Natural killer cell mediated cytotoxicity 18:0-LPC+blood -0.526315789 0 0 kegg serum_phospholipids NA 0.554 no no no no no no NF-kappa B signaling pathway 18:0-LPC+blood 0 0 0.403076923 kegg serum_phospholipids NA 0.554 no no no no no no Oocyte meiosis 18:0-LPC+blood 0.615789474 0 0 kegg serum_phospholipids NA 0.554 no no no no no no "Parathyroid hormone synthesis, secretion and action" 18:0-LPC+blood 0 0.573529412 0 kegg serum_phospholipids NA 0.554 no no no no no no Phagosome 18:0-LPC+blood -0.542105263 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Prevotella 18:0-LPC+blood 0 0 0.415602834 acetate-producing Genus serum_phospholipids 0.287 0.554 no no no no no no Proteasome 18:0-LPC+blood 0 0 -0.427692308 kegg serum_phospholipids NA 0.554 no no no no no no Purine metabolism 18:0-LPC+blood 0 0.547058824 0 kegg serum_phospholipids NA 0.554 no no no no no no Regulation of actin cytoskeleton 18:0-LPC+blood 0 0 -0.41 kegg serum_phospholipids NA 0.554 no no no no no no Rheumatoid arthritis 18:0-LPC+blood -0.587719298 -0.561764706 0 kegg serum_phospholipids NA 0.554 no no no no no no Ribosome biogenesis in eukaryotes 18:0-LPC+blood 0.503508772 0 0 kegg serum_phospholipids NA 0.554 no no no no no no RIG-I-like receptor signaling pathway 18:0-LPC+blood 0 0 0.412307692 kegg serum_phospholipids NA 0.554 no no no no no no RNA degradation 18:0-LPC+blood 0.456140351 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Salmonella infection 18:0-LPC+blood 0 -0.65 0 kegg serum_phospholipids NA 0.554 no no no no no no Staphylococcus aureus infection 18:0-LPC+blood 0 -0.529411765 0 kegg serum_phospholipids NA 0.554 up no no no no no Th1 and Th2 cell differentiation 18:0-LPC+blood 0 -0.558823529 0 kegg serum_phospholipids NA 0.554 no no no no no no Tight junction 18:0-LPC+blood 0 0 -0.466923077 kegg serum_phospholipids NA 0.554 no no no no no no Toxoplasmosis 18:0-LPC+blood 0 -0.6 0 kegg serum_phospholipids NA 0.554 no no no no no no Transcriptional misregulation in cancer 18:0-LPC+blood 0 0 0.546923077 kegg serum_phospholipids NA 0.554 no no no no no no Tuberculosis 18:0-LPC+blood 0 -0.544117647 0 kegg serum_phospholipids NA 0.554 no no dn no no no Type I diabetes mellitus 18:0-LPC+blood -0.592982456 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Viral carcinogenesis 18:0-LPC+blood -0.628070175 0 0 kegg serum_phospholipids NA 0.554 no no no no no no Viral myocarditis 18:0-LPC+blood -0.621052632 0 0 kegg serum_phospholipids NA 0.554 no no no no no no 16:0-LPE+blood 18:0-LPE+blood 0.607518797 0.583333333 0.543247863 serum_phospholipids serum_phospholipids 0.0711 0.491 up up no no no no 16:0/16:0-PC+blood 18:0-LPE+blood 0 -0.578431373 0 serum_phospholipids serum_phospholipids 0.00079 0.491 no up up no no no 16:0/16:0-PI+blood 18:0-LPE+blood 0.45112782 0 0 serum_phospholipids serum_phospholipids 0.358 0.491 no no no no no no 16:0/18:0-PS+blood 18:0-LPE+blood 0.640601504 0 0 serum_phospholipids serum_phospholipids 0.377 0.491 no no no no no no 16:0/18:1-PC+blood 18:0-LPE+blood 0 -0.536764706 0 serum_phospholipids serum_phospholipids 6.15E-07 0.491 up up up no no no 16:0/18:1-PE+blood 18:0-LPE+blood 0.615037594 0 0 serum_phospholipids serum_phospholipids 0.000107 0.491 up up no no no no 16:0/18:2-PC+blood 18:0-LPE+blood -0.463157895 -0.490196078 0 serum_phospholipids serum_phospholipids 3.24E-06 0.491 no up up no no no 16:0/20:3-PC+blood 18:0-LPE+blood -0.532330827 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.491 no up up no no no 16:0/20:4-PC+blood 18:0-LPE+blood -0.50075188 0 0 serum_phospholipids serum_phospholipids 0.0262 0.491 no up no no no no 16:0/20:4-PE+blood 18:0-LPE+blood 0.702255639 0 0 serum_phospholipids serum_phospholipids 0.00139 0.491 up up no no no no 16:0/22:0-PE+blood 18:0-LPE+blood 0 -0.62745098 0 serum_phospholipids serum_phospholipids 0.00839 0.491 dn no up no no no 16:0/22:6-PE+blood 18:0-LPE+blood 0.688721805 0 0 serum_phospholipids serum_phospholipids 0.000934 0.491 up up no no no no 16:1-LPC+blood 18:0-LPE+blood 0 0.50245098 0 serum_phospholipids serum_phospholipids 0.0241 0.491 no up no no no no 18:0-LPC+blood 18:0-LPE+blood 0.598496241 0.732843137 0.464615385 serum_phospholipids serum_phospholipids 0.554 0.491 no no no no no no Allograft rejection 18:0-LPE+blood -0.547368421 0 0 kegg serum_phospholipids NA 0.491 no no no no no no Amoebiasis 18:0-LPE+blood 0 0 0.426153846 kegg serum_phospholipids NA 0.491 no no no no no no Asthma 18:0-LPE+blood -0.457894737 -0.541176471 0 kegg serum_phospholipids NA 0.491 no no no no no no Autoimmune thyroid disease 18:0-LPE+blood -0.547368421 0 0 kegg serum_phospholipids NA 0.491 no no no no no no Cell adhesion molecules 18:0-LPE+blood -0.487719298 0 0 kegg serum_phospholipids NA 0.491 no no no no no no Cellular senescence 18:0-LPE+blood -0.545614035 0 0 kegg serum_phospholipids NA 0.491 no no no no no no Cytosolic DNA-sensing pathway 18:0-LPE+blood -0.592982456 0 0 kegg serum_phospholipids NA 0.491 no no no no no no Fusobacterium 18:0-LPE+blood 0 0.561103984 0 Genus serum_phospholipids 0.628 0.491 no no no no no no Graft-versus-host disease 18:0-LPE+blood -0.547368421 0 0 kegg serum_phospholipids NA 0.491 no no no no no no Hematopoietic cell lineage 18:0-LPE+blood 0 -0.579411765 0 kegg serum_phospholipids NA 0.491 no no no no no no Hepatitis B 18:0-LPE+blood 0 0 0.414615385 kegg serum_phospholipids NA 0.491 no no no no no no Human cytomegalovirus infection 18:0-LPE+blood -0.463157895 0 0 kegg serum_phospholipids NA 0.491 no no dn no no no Human papillomavirus infection 18:0-LPE+blood -0.492982456 0 0 kegg serum_phospholipids NA 0.491 no no no no no no Inflammatory bowel disease 18:0-LPE+blood 0 -0.544117647 0 kegg serum_phospholipids NA 0.491 no no no no no no Influenza A 18:0-LPE+blood -0.485964912 0 0 kegg serum_phospholipids NA 0.491 no no no no no no Kaposi sarcoma-associated herpesvirus infection 18:0-LPE+blood -0.457894737 0 0 kegg serum_phospholipids NA 0.491 no no dn no no no L-Phenylalanine+stool 18:0-LPE+blood 0 0 -0.557894737 stool_cometabolism serum_phospholipids 0.398 0.491 no no no no no no L-Tyrosine+stool 18:0-LPE+blood 0 0 -0.541353383 stool_cometabolism serum_phospholipids 0.44 0.491 no no no no no no Longevity regulating pathway - multiple species 18:0-LPE+blood 0.59122807 0 0 kegg serum_phospholipids NA 0.491 no no no no no no Malaria 18:0-LPE+blood 0 0.682352941 0 kegg serum_phospholipids NA 0.491 no no no no no no MAPK signaling pathway 18:0-LPE+blood 0.68245614 0 0 kegg serum_phospholipids NA 0.491 no no no no no no Olfactory transduction 18:0-LPE+blood 0.48245614 0 0 kegg serum_phospholipids NA 0.491 no no no no no no Propionic acid+stool 18:0-LPE+blood 0 0.609090909 0 yes stool_scfa serum_phospholipids 0.0436 0.491 dn no up no no no Proteasome 18:0-LPE+blood 0 0 -0.526153846 kegg serum_phospholipids NA 0.491 no no no no no no Rheumatoid arthritis 18:0-LPE+blood -0.5 0 0 kegg serum_phospholipids NA 0.491 no no no no no no Th1 and Th2 cell differentiation 18:0-LPE+blood -0.475438596 -0.588235294 0 kegg serum_phospholipids NA 0.491 no no no no no no Th17 cell differentiation 18:0-LPE+blood 0 -0.529411765 0 kegg serum_phospholipids NA 0.491 no no no no no no Toxoplasmosis 18:0-LPE+blood 0 -0.602941176 0 kegg serum_phospholipids NA 0.491 no no no no no no Transcriptional misregulation in cancer 18:0-LPE+blood 0 0 0.490769231 kegg serum_phospholipids NA 0.491 no no no no no no Type I diabetes mellitus 18:0-LPE+blood -0.547368421 0 0 kegg serum_phospholipids NA 0.491 no no no no no no Viral carcinogenesis 18:0-LPE+blood -0.535087719 0 0.416923077 kegg serum_phospholipids NA 0.491 no no no no no no Viral myocarditis 18:0-LPE+blood -0.536842105 0 0 kegg serum_phospholipids NA 0.491 no no no no no no 13-HODE+blood 18:0/16:0-PC+blood 0 0.517156863 0 serum_ARA serum_phospholipids 0.32 9.64E-07 no no no up up up 14:0/18:0-PC+blood 18:0/16:0-PC+blood 0 0 0.558974359 serum_phospholipids serum_phospholipids 0.00289 9.64E-07 up up no up up up 14:0/20:4-PC+blood 18:0/16:0-PC+blood 0 0 -0.414017094 serum_phospholipids serum_phospholipids 0.486 9.64E-07 no no no up up up 16:0/14:0-PC+blood 18:0/16:0-PC+blood 0.631578947 0.588235294 0 serum_phospholipids serum_phospholipids 0.0206 9.64E-07 no up up up up up 16:0/16:0-PC+blood 18:0/16:0-PC+blood 0.606015038 0.68872549 0 serum_phospholipids serum_phospholipids 0.00079 9.64E-07 no up up up up up 16:0/16:0-PI+blood 18:0/16:0-PC+blood -0.556390977 0 0 serum_phospholipids serum_phospholipids 0.358 9.64E-07 no no no up up up 16:0/16:1-PC+blood 18:0/16:0-PC+blood 0 0 0.528888889 serum_phospholipids serum_phospholipids 0.00283 9.64E-07 up up no up up up 16:0/16:1-PI+blood 18:0/16:0-PC+blood -0.690225564 0 0 serum_phospholipids serum_phospholipids 0.262 9.64E-07 no no no up up up 16:0/18:0-PC+blood 18:0/16:0-PC+blood 0.488721805 0 0 serum_phospholipids serum_phospholipids 0.521 9.64E-07 no no no up up up 16:0/18:1-PC+blood 18:0/16:0-PC+blood 0.984962406 0.973039216 0.99042735 serum_phospholipids serum_phospholipids 6.15E-07 9.64E-07 up up up up up up 16:0/18:1-PE+blood 18:0/16:0-PC+blood -0.521804511 0 0 serum_phospholipids serum_phospholipids 0.000107 9.64E-07 up up no up up up 16:0/18:2-PC+blood 18:0/16:0-PC+blood 0.833082707 0.909313725 0.712136752 serum_phospholipids serum_phospholipids 3.24E-06 9.64E-07 no up up up up up 16:0/18:2-PI+blood 18:0/16:0-PC+blood -0.685714286 0 0 serum_phospholipids serum_phospholipids 0.269 9.64E-07 no no no up up up 16:0/20:3-PC+blood 18:0/16:0-PC+blood 0.506766917 0.566176471 0.551452991 serum_phospholipids serum_phospholipids 5.43E-06 9.64E-07 no up up up up up 16:0/20:4-PC+blood 18:0/16:0-PC+blood 0.712781955 0.617647059 0 serum_phospholipids serum_phospholipids 0.0262 9.64E-07 no up no up up up 16:0/20:4-PI+blood 18:0/16:0-PC+blood -0.637593985 -0.536764706 0 serum_phospholipids serum_phospholipids 0.558 9.64E-07 no no no up up up 16:0/22:6-PC+blood 18:0/16:0-PC+blood 0.517293233 0.588235294 0.443418803 serum_phospholipids serum_phospholipids 4.53E-05 9.64E-07 no up up up up up 16:0+blood 18:0/16:0-PC+blood 0 0 0.433162393 yes serum_fattyacid serum_phospholipids 0.00876 9.64E-07 up no no up up up 16:1/16:0-PC+blood 18:0/16:0-PC+blood 0.837593985 0.705882353 0.545299145 serum_phospholipids serum_phospholipids 0.0215 9.64E-07 no up up up up up 16:1/16:1-PC+blood 18:0/16:0-PC+blood 0.819548872 0 0.548717949 serum_phospholipids serum_phospholipids 0.0177 9.64E-07 no no up up up up 16:1/18:1-PG+blood 18:0/16:0-PC+blood 0.560902256 0 0 serum_phospholipids serum_phospholipids 3.21E-05 9.64E-07 no up up up up up 16:1/18:2-PG+blood 18:0/16:0-PC+blood 0.57593985 0 0 serum_phospholipids serum_phospholipids 1.40E-08 9.64E-07 no up up up up up 16:1+blood 18:0/16:0-PC+blood 0 0 0.51042735 yes serum_fattyacid serum_phospholipids 0.0186 9.64E-07 no no dn up up up 18:0-LPC+blood 18:0/16:0-PC+blood 0 -0.539215686 0 serum_phospholipids serum_phospholipids 0.554 9.64E-07 no no no up up up 18:0-LPE+blood 18:0/16:0-PC+blood 0 -0.495098039 0 serum_phospholipids serum_phospholipids 0.491 9.64E-07 no no no up up up Adherens junction 18:0/16:0-PC+blood 0 0 -0.466153846 kegg serum_phospholipids NA 9.64E-07 no no no up up up Adrenergic signaling in cardiomyocytes 18:0/16:0-PC+blood 0 -0.55 0 kegg serum_phospholipids NA 9.64E-07 no no up up up up Alistipes 18:0/16:0-PC+blood 0.453588135 0 0 Genus serum_phospholipids 0.0114 9.64E-07 no up no up up up AMPK signaling pathway 18:0/16:0-PC+blood 0 -0.676470588 0 kegg serum_phospholipids NA 9.64E-07 no no no up up up Apelin signaling pathway 18:0/16:0-PC+blood 0 0 0.400769231 kegg serum_phospholipids NA 9.64E-07 no no no up up up Arginine and proline metabolism 18:0/16:0-PC+blood 0 0 0.438461538 kegg serum_phospholipids NA 9.64E-07 no up no up up up Arrhythmogenic right ventricular cardiomyopathy 18:0/16:0-PC+blood 0 0 -0.491538462 kegg serum_phospholipids NA 9.64E-07 no up up up up up Central carbon metabolism in cancer 18:0/16:0-PC+blood 0 -0.717647059 0 kegg serum_phospholipids NA 9.64E-07 no no no up up up Cytokine-cytokine receptor interaction 18:0/16:0-PC+blood 0 0 -0.412307692 kegg serum_phospholipids NA 9.64E-07 no no no up up up Dilated cardiomyopathy 18:0/16:0-PC+blood 0 0 -0.566153846 kegg serum_phospholipids NA 9.64E-07 no up up up up up EGFR tyrosine kinase inhibitor resistance 18:0/16:0-PC+blood 0 0 0.469230769 kegg serum_phospholipids NA 9.64E-07 no no no up up up Epstein-Barr virus infection 18:0/16:0-PC+blood 0 0 0.458461538 kegg serum_phospholipids NA 9.64E-07 no no no up up up Focal adhesion 18:0/16:0-PC+blood 0 0 -0.439230769 kegg serum_phospholipids NA 9.64E-07 no up up up up up Fusobacterium 18:0/16:0-PC+blood 0 -0.653861011 0 Genus serum_phospholipids 0.628 9.64E-07 no no no up up up Gap junction 18:0/16:0-PC+blood 0 0 -0.473076923 kegg serum_phospholipids NA 9.64E-07 no no no up up up Gastric acid secretion 18:0/16:0-PC+blood 0 0 -0.517692308 kegg serum_phospholipids NA 9.64E-07 no no no up up up GCA+stool 18:0/16:0-PC+blood 0 0 0.553383459 stool_bileacids serum_phospholipids 0.0809 9.64E-07 no no no up up up "Glycine, serine and threonine metabolism" 18:0/16:0-PC+blood 0 -0.564705882 0 kegg serum_phospholipids NA 9.64E-07 no up no up up up HDCA+stool 18:0/16:0-PC+blood 0.626373626 0 0 stool_bileacids serum_phospholipids 0.176 9.64E-07 no no no up up up Hepatocellular carcinoma 18:0/16:0-PC+blood 0 0 -0.489230769 kegg serum_phospholipids NA 9.64E-07 no no no up up up HIF-1 signaling pathway 18:0/16:0-PC+blood 0 0 0.496923077 kegg serum_phospholipids NA 9.64E-07 no no no up up up Hippo signaling pathway 18:0/16:0-PC+blood 0 0 -0.487692308 kegg serum_phospholipids NA 9.64E-07 no no no up up up Human immunodeficiency virus 1 infection 18:0/16:0-PC+blood 0 0 0.446153846 kegg serum_phospholipids NA 9.64E-07 no no no up up up Human T-cell leukemia virus 1 infection 18:0/16:0-PC+blood 0 0 0.413076923 kegg serum_phospholipids NA 9.64E-07 no no no up up up Hypertrophic cardiomyopathy 18:0/16:0-PC+blood 0 0 -0.510769231 kegg serum_phospholipids NA 9.64E-07 no up up up up up Insulin signaling pathway 18:0/16:0-PC+blood 0 0 0.438461538 kegg serum_phospholipids NA 9.64E-07 no no no up up up LCA+stool 18:0/16:0-PC+blood 0.576923077 0 0 stool_bileacids serum_phospholipids 0.314 9.64E-07 no no no up up up mTOR signaling pathway 18:0/16:0-PC+blood 0 -0.520588235 0.563846154 kegg serum_phospholipids NA 9.64E-07 no no no up up up Phenylacetic acid+stool 18:0/16:0-PC+blood 0 -0.627272727 0 stool_cometabolism serum_phospholipids 0.785 9.64E-07 no no no up up up Platelet activation 18:0/16:0-PC+blood 0 0 -0.511538462 kegg serum_phospholipids NA 9.64E-07 no no no up up up Proteasome 18:0/16:0-PC+blood 0 0 0.595384615 kegg serum_phospholipids NA 9.64E-07 no no no up up up Rap1 signaling pathway 18:0/16:0-PC+blood 0 0 -0.512307692 kegg serum_phospholipids NA 9.64E-07 no no no up up up Renal cell carcinoma 18:0/16:0-PC+blood 0 -0.502941176 0 kegg serum_phospholipids NA 9.64E-07 no no no up up up TCA+stool 18:0/16:0-PC+blood -0.718019936 0 0.463157895 stool_bileacids serum_phospholipids 0.458 9.64E-07 no no no up up up Th1 and Th2 cell differentiation 18:0/16:0-PC+blood 0 0.535294118 0 kegg serum_phospholipids NA 9.64E-07 no no no up up up Thyroid hormone signaling pathway 18:0/16:0-PC+blood 0 0 -0.506923077 kegg serum_phospholipids NA 9.64E-07 no no no up up up Toxoplasmosis 18:0/16:0-PC+blood 0 0.558823529 0 kegg serum_phospholipids NA 9.64E-07 no no no up up up Vibrio cholerae infection 18:0/16:0-PC+blood 0 0 -0.458461538 kegg serum_phospholipids NA 9.64E-07 no no no up up up Viral myocarditis 18:0/16:0-PC+blood 0 0.5 0 kegg serum_phospholipids NA 9.64E-07 no no no up up up 14:0/18:0-PC+blood 18:0/18:0-PC+blood 0 0.539215686 0 serum_phospholipids serum_phospholipids 0.00289 0.426 up up no no no no 16:0/16:1-PC+blood 18:0/18:0-PC+blood 0 0.585784314 0 serum_phospholipids serum_phospholipids 0.00283 0.426 up up no no no no 16:0/16:1-PI+blood 18:0/18:0-PC+blood 0 0.615196078 0 serum_phospholipids serum_phospholipids 0.262 0.426 no no no no no no 16:0/18:0-PC+blood 18:0/18:0-PC+blood 0.54887218 0 0.522735043 serum_phospholipids serum_phospholipids 0.521 0.426 no no no no no no 16:0/20:3-PC+blood 18:0/18:0-PC+blood 0 0.546568627 0 serum_phospholipids serum_phospholipids 5.43E-06 0.426 no up up no no no 16:1-LPC+blood 18:0/18:0-PC+blood -0.54887218 0 0 serum_phospholipids serum_phospholipids 0.0241 0.426 no up no no no no Arrhythmogenic right ventricular cardiomyopathy 18:0/18:0-PC+blood 0 0.5 0 kegg serum_phospholipids NA 0.426 no up up no no no Fusobacterium 18:0/18:0-PC+blood 0 -0.51244456 0 Genus serum_phospholipids 0.628 0.426 no no no no no no GCDCA+stool 18:0/18:0-PC+blood 0 0 0.452631579 yes stool_bileacids serum_phospholipids 0.0471 0.426 no dn no no no no GDCA+stool 18:0/18:0-PC+blood 0 0 0.597892244 stool_bileacids serum_phospholipids 0.656 0.426 no no no no no no "Growth hormone synthesis, secretion and action" 18:0/18:0-PC+blood 0 -0.608823529 0 kegg serum_phospholipids NA 0.426 no no no no no no Hippo signaling pathway 18:0/18:0-PC+blood 0 0.555882353 0 kegg serum_phospholipids NA 0.426 no no no no no no nutriCA+stool 18:0/18:0-PC+blood 0 0.789024032 0 stool_bileacids serum_phospholipids 0.481 0.426 no no no no no no Propionic acid+stool 18:0/18:0-PC+blood 0 0 -0.484210526 yes stool_scfa serum_phospholipids 0.0436 0.426 dn no up no no no Ruminococcus 18:0/18:0-PC+blood 0 0.495098039 0 acetate-producing Genus serum_phospholipids 0.335 0.426 no no no no no no TCA+stool 18:0/18:0-PC+blood 0 0 0.481203008 stool_bileacids serum_phospholipids 0.458 0.426 no no no no no no 12-HEPE+blood 18:0/18:0-PE+blood 0 0 -0.48938247 serum_ARA serum_phospholipids 0.312 0.00896 no no no up up no 12-ketoDCA+blood 18:0/18:0-PE+blood 0 -0.497270443 0 serum_bileacids serum_phospholipids 0.517 0.00896 no no no up up no "12,13-EPOME+blood" 18:0/18:0-PE+blood 0 0.574965901 0 serum_ARA serum_phospholipids 0.901 0.00896 no no no up up no 13-HODE+blood 18:0/18:0-PE+blood -0.652631579 0 0 serum_ARA serum_phospholipids 0.32 0.00896 no no no up up no 16:0-LPC+blood 18:0/18:0-PE+blood 0 0 0.423589744 serum_phospholipids serum_phospholipids 0.00456 0.00896 up up no up up no 16:0-LPE+blood 18:0/18:0-PE+blood 0.493233083 0 0 serum_phospholipids serum_phospholipids 0.0711 0.00896 up up no up up no 16:0/14:0-PC+blood 18:0/18:0-PE+blood -0.479699248 0 -0.522735043 serum_phospholipids serum_phospholipids 0.0206 0.00896 no up up up up no 16:0/16:0-PI+blood 18:0/18:0-PE+blood 0.508270677 0.512254902 0 serum_phospholipids serum_phospholipids 0.358 0.00896 no no no up up no 16:0/16:1-PC+blood 18:0/18:0-PE+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.00283 0.00896 up up no up up no 16:0/16:1-PI+blood 18:0/18:0-PE+blood 0.45112782 0.490196078 0 serum_phospholipids serum_phospholipids 0.262 0.00896 no no no up up no 16:0/18:0-PS+blood 18:0/18:0-PE+blood 0.496240602 0 0 serum_phospholipids serum_phospholipids 0.377 0.00896 no no no up up no 16:0/18:1-PC+blood 18:0/18:0-PE+blood -0.613533835 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.00896 up up up up up no 16:0/18:1-PE+blood 18:0/18:0-PE+blood 0.763909774 0.526960784 0 serum_phospholipids serum_phospholipids 0.000107 0.00896 up up no up up no 16:0/18:2-PC+blood 18:0/18:0-PE+blood -0.678195489 0 -0.477606838 serum_phospholipids serum_phospholipids 3.24E-06 0.00896 no up up up up no 16:0/18:2-PI+blood 18:0/18:0-PE+blood 0.446616541 0.666666667 0 serum_phospholipids serum_phospholipids 0.269 0.00896 no no no up up no 16:0/20:3-PC+blood 18:0/18:0-PE+blood -0.598496241 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.00896 no up up up up no 16:0/20:4-PC+blood 18:0/18:0-PE+blood -0.470676692 -0.745098039 0 serum_phospholipids serum_phospholipids 0.0262 0.00896 no up no up up no 16:0/20:4-PE+blood 18:0/18:0-PE+blood 0.580451128 0 0 serum_phospholipids serum_phospholipids 0.00139 0.00896 up up no up up no 16:0/20:4-PI+blood 18:0/18:0-PE+blood 0.556390977 0 0 serum_phospholipids serum_phospholipids 0.558 0.00896 no no no up up no 16:0/22:6-PC+blood 18:0/18:0-PE+blood 0 -0.571078431 0 serum_phospholipids serum_phospholipids 4.53E-05 0.00896 no up up up up no 16:0/22:6-PE+blood 18:0/18:0-PE+blood 0.648120301 0 0 serum_phospholipids serum_phospholipids 0.000934 0.00896 up up no up up no 16:1/16:0-PC+blood 18:0/18:0-PE+blood -0.589473684 0 -0.566495726 serum_phospholipids serum_phospholipids 0.0215 0.00896 no up up up up no 16:1/16:1-PC+blood 18:0/18:0-PE+blood -0.482706767 0 -0.530940171 serum_phospholipids serum_phospholipids 0.0177 0.00896 no no up up up no 16:1/18:1-PG+blood 18:0/18:0-PE+blood -0.448120301 0 0 serum_phospholipids serum_phospholipids 3.21E-05 0.00896 no up up up up no 16:1/18:2-PG+blood 18:0/18:0-PE+blood -0.670676692 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.00896 no up up up up no 18:0-LPE+blood 18:0/18:0-PE+blood 0.615037594 0 0.420854701 serum_phospholipids serum_phospholipids 0.491 0.00896 no no no up up no 18:0/16:0-PC+blood 18:0/18:0-PE+blood -0.584962406 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.00896 up up up up up no 12-HEPE+blood 18:0/18:0-PS+blood -0.585380137 0 0 serum_ARA serum_phospholipids 0.312 0.00617 no no no no up no 12-ketoDCA+blood 18:0/18:0-PS+blood 0 -0.543374987 0 serum_bileacids serum_phospholipids 0.517 0.00617 no no no no up no 13-HODE+blood 18:0/18:0-PS+blood 0 -0.651960784 0 serum_ARA serum_phospholipids 0.32 0.00617 no no no no up no 15-HETE+blood 18:0/18:0-PS+blood -0.484862399 0 0 serum_ARA serum_phospholipids 0.819 0.00617 no no no no up no 16:0/14:0-PC+blood 18:0/18:0-PS+blood 0 0 -0.507008547 serum_phospholipids serum_phospholipids 0.0206 0.00617 no up up no up no 16:0/18:0-PS+blood 18:0/18:0-PS+blood 0.905263158 0.87254902 0.961025641 serum_phospholipids serum_phospholipids 0.377 0.00617 no no no no up no 16:0/18:1-PE+blood 18:0/18:0-PS+blood 0 0 0.558290598 serum_phospholipids serum_phospholipids 0.000107 0.00617 up up no no up no 16:0/20:4-PE+blood 18:0/18:0-PS+blood 0.603007519 0 0.570598291 serum_phospholipids serum_phospholipids 0.00139 0.00617 up up no no up no 16:0/20:5-PC+blood 18:0/18:0-PS+blood 0 0.524509804 0 serum_phospholipids serum_phospholipids 0.628 0.00617 no no no no up no 16:0/20:5-PG+blood 18:0/18:0-PS+blood 0 0 0.436581197 serum_phospholipids serum_phospholipids 0.00656 0.00617 no up no no up no 16:0/22:6-PE+blood 18:0/18:0-PS+blood 0.742857143 0.644607843 0.638290598 serum_phospholipids serum_phospholipids 0.000934 0.00617 up up no no up no 16:1/18:1-PG+blood 18:0/18:0-PS+blood 0 0 0.619145299 serum_phospholipids serum_phospholipids 3.21E-05 0.00617 no up up no up no 16:1/18:2-PG+blood 18:0/18:0-PS+blood 0 0 0.424273504 serum_phospholipids serum_phospholipids 1.40E-08 0.00617 no up up no up no 16:1+blood 18:0/18:0-PS+blood 0 0.49754902 0 yes serum_fattyacid serum_phospholipids 0.0186 0.00617 no no dn no up no 18:0-LPE+blood 18:0/18:0-PS+blood 0.494736842 0 0 serum_phospholipids serum_phospholipids 0.491 0.00617 no no no no up no 18:0/18:0-PC+blood 18:0/18:0-PS+blood 0 0.49754902 0 serum_phospholipids serum_phospholipids 0.426 0.00617 no no no no up no 18:0+blood 18:0/18:0-PS+blood 0 0.600490196 0 serum_fattyacid serum_phospholipids 0.344 0.00617 no no no no up no Acetic acid+stool 18:0/18:0-PS+blood 0 -0.645454545 0 yes stool_scfa serum_phospholipids 0.0656 0.00617 dn no no no up no Adipocytokine signaling pathway 18:0/18:0-PS+blood -0.566666667 -0.638235294 0 kegg serum_phospholipids NA 0.00617 no no no no up no Adrenergic signaling in cardiomyocytes 18:0/18:0-PS+blood -0.478947368 0 0 kegg serum_phospholipids NA 0.00617 no no up no up no Biosynthesis of amino acids 18:0/18:0-PS+blood 0.535087719 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no cAMP signaling pathway 18:0/18:0-PS+blood -0.501754386 -0.614705882 0 yes kegg serum_phospholipids NA 0.00617 no up up no up no Carbon metabolism 18:0/18:0-PS+blood 0.549122807 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Cellular senescence 18:0/18:0-PS+blood 0 0 0.436153846 kegg serum_phospholipids NA 0.00617 no no no no up no Chagas disease 18:0/18:0-PS+blood -0.48245614 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Chronic myeloid leukemia 18:0/18:0-PS+blood -0.492982456 -0.585294118 0 kegg serum_phospholipids NA 0.00617 no no no no up no Clostridium 18:0/18:0-PS+blood 0 0.533331721 0 Genus serum_phospholipids 0.925 0.00617 no no no no up no Collinsella 18:0/18:0-PS+blood 0.50602467 0 0 Genus serum_phospholipids 0.128 0.00617 no no no no up no Cytosolic DNA-sensing pathway 18:0/18:0-PS+blood 0 -0.638235294 0 kegg serum_phospholipids NA 0.00617 no no no no up no DCA+stool 18:0/18:0-PS+blood 0 0 0.503759398 stool_bileacids serum_phospholipids 0.195 0.00617 no no no no up no Dopaminergic synapse 18:0/18:0-PS+blood -0.477192982 0 0 kegg serum_phospholipids NA 0.00617 no up no no up no Fc gamma R-mediated phagocytosis 18:0/18:0-PS+blood 0.494736842 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Glycolysis / Gluconeogenesis 18:0/18:0-PS+blood 0.561403509 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Hepatitis C 18:0/18:0-PS+blood 0 -0.602941176 0 kegg serum_phospholipids NA 0.00617 no no no no up no Human cytomegalovirus infection 18:0/18:0-PS+blood 0 0 0.416153846 kegg serum_phospholipids NA 0.00617 no no dn no up no Human papillomavirus infection 18:0/18:0-PS+blood 0 0 0.437692308 kegg serum_phospholipids NA 0.00617 no no no no up no Intestinal immune network for IgA production 18:0/18:0-PS+blood -0.529824561 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Kaposi sarcoma-associated herpesvirus infection 18:0/18:0-PS+blood -0.642105263 0 0 kegg serum_phospholipids NA 0.00617 no no dn no up no Long-term depression 18:0/18:0-PS+blood -0.457894737 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Longevity regulating pathway 18:0/18:0-PS+blood -0.498245614 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Longevity regulating pathway - multiple species 18:0/18:0-PS+blood 0.601754386 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Mitophagy - animal 18:0/18:0-PS+blood -0.487719298 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no mRNA surveillance pathway 18:0/18:0-PS+blood -0.48245614 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Necroptosis 18:0/18:0-PS+blood -0.456140351 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Neurotrophin signaling pathway 18:0/18:0-PS+blood 0 -0.567647059 0 kegg serum_phospholipids NA 0.00617 no no no no up no Parkinson disease 18:0/18:0-PS+blood -0.547368421 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Pathways of neurodegeneration - multiple diseases 18:0/18:0-PS+blood -0.540350877 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Peroxisome 18:0/18:0-PS+blood 0.475438596 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Primary immunodeficiency 18:0/18:0-PS+blood 0.543859649 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Propionic acid+stool 18:0/18:0-PS+blood 0 0 0.521804511 yes stool_scfa serum_phospholipids 0.0436 0.00617 dn no up no up no Prostate cancer 18:0/18:0-PS+blood 0 -0.591176471 0 kegg serum_phospholipids NA 0.00617 no no no no up no Relaxin signaling pathway 18:0/18:0-PS+blood -0.668421053 -0.502941176 0 kegg serum_phospholipids NA 0.00617 no no no no up no Shigellosis 18:0/18:0-PS+blood -0.540350877 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Th1 and Th2 cell differentiation 18:0/18:0-PS+blood -0.507017544 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no Th17 cell differentiation 18:0/18:0-PS+blood -0.58245614 0 0 kegg serum_phospholipids NA 0.00617 no no no no up no TNF signaling pathway 18:0/18:0-PS+blood -0.522807018 -0.511764706 0 kegg serum_phospholipids NA 0.00617 no no no no up no Viral carcinogenesis 18:0/18:0-PS+blood 0 0 0.445384615 kegg serum_phospholipids NA 0.00617 no no no no up no 14:0/18:0-PC+blood 18:0/18:1-PC+blood 0 0.558823529 0 serum_phospholipids serum_phospholipids 0.00289 0.393 up up no no no no 16:0/16:1-PC+blood 18:0/18:1-PC+blood 0 0.605392157 0 serum_phospholipids serum_phospholipids 0.00283 0.393 up up no no no no 16:0/16:1-PI+blood 18:0/18:1-PC+blood 0 0.634803922 0 serum_phospholipids serum_phospholipids 0.262 0.393 no no no no no no 16:0/18:0-PC+blood 18:0/18:1-PC+blood 0.547368421 0 0.505641026 serum_phospholipids serum_phospholipids 0.521 0.393 no no no no no no 16:0/18:1-PC+blood 18:0/18:1-PC+blood 0.44962406 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.393 up up up no no no 16:0/20:3-PC+blood 18:0/18:1-PC+blood 0 0.517156863 0 serum_phospholipids serum_phospholipids 5.43E-06 0.393 no up up no no no 16:1-LPC+blood 18:0/18:1-PC+blood -0.463157895 0 0 serum_phospholipids serum_phospholipids 0.0241 0.393 no up no no no no 18:0-LPC+blood 18:0/18:1-PC+blood 0 0 0.40034188 serum_phospholipids serum_phospholipids 0.554 0.393 no no no no no no 18:0/16:0-PC+blood 18:0/18:1-PC+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.393 up up up no no no 18:0/18:0-PC+blood 18:0/18:1-PC+blood 0.972932331 0.990196078 0.993846154 serum_phospholipids serum_phospholipids 0.426 0.393 no no no no no no 18:0/18:0-PS+blood 18:0/18:1-PC+blood 0 0.522058824 0 serum_phospholipids serum_phospholipids 0.00617 0.393 no up no no no no Adherens junction 18:0/18:1-PC+blood 0 0.502941176 0 kegg serum_phospholipids NA 0.393 no no no no no no Arrhythmogenic right ventricular cardiomyopathy 18:0/18:1-PC+blood 0 0.541176471 0 kegg serum_phospholipids NA 0.393 no up up no no no Fusobacterium 18:0/18:1-PC+blood 0 -0.51244456 0 Genus serum_phospholipids 0.628 0.393 no no no no no no GCDCA+stool 18:0/18:1-PC+blood 0 0 0.44962406 yes stool_bileacids serum_phospholipids 0.0471 0.393 no dn no no no no GDCA+stool 18:0/18:1-PC+blood 0 0 0.600904296 stool_bileacids serum_phospholipids 0.656 0.393 no no no no no no "Growth hormone synthesis, secretion and action" 18:0/18:1-PC+blood 0 -0.573529412 0 kegg serum_phospholipids NA 0.393 no no no no no no Hippo signaling pathway 18:0/18:1-PC+blood 0 0.597058824 0 kegg serum_phospholipids NA 0.393 no no no no no no NOD-like receptor signaling pathway 18:0/18:1-PC+blood 0 -0.505882353 0 kegg serum_phospholipids NA 0.393 no no no no no no nutriCA+stool 18:0/18:1-PC+blood 0 0.789024032 0 stool_bileacids serum_phospholipids 0.481 0.393 no no no no no no Parabacteroides 18:0/18:1-PC+blood 0.490225564 0 0 Genus serum_phospholipids 4.19E-05 0.393 no up up no no no Propionic acid+stool 18:0/18:1-PC+blood 0 0 -0.47518797 yes stool_scfa serum_phospholipids 0.0436 0.393 dn no up no no no TCA+stool 18:0/18:1-PC+blood 0 0 0.487218045 stool_bileacids serum_phospholipids 0.458 0.393 no no no no no no Thyroid hormone signaling pathway 18:0/18:1-PC+blood 0 0.526470588 0 kegg serum_phospholipids NA 0.393 no no no no no no 12-ketoDCA+blood 18:0/18:1-PE+blood 0 -0.507149988 0 serum_bileacids serum_phospholipids 0.517 0.00716 no no no up up no 12-ketoDCA+stool 18:0/18:1-PE+blood 0 0 0.607518797 stool_bileacids serum_phospholipids 0.505 0.00716 no no no up up no "12,13-EPOME+blood" 18:0/18:1-PE+blood 0 0.589997689 0 serum_ARA serum_phospholipids 0.901 0.00716 no no no up up no 13-HODE+blood 18:0/18:1-PE+blood -0.652631579 0 0 serum_ARA serum_phospholipids 0.32 0.00716 no no no up up no 14:0/18:0-PC+blood 18:0/18:1-PE+blood 0 0.546568627 0 serum_phospholipids serum_phospholipids 0.00289 0.00716 up up no up up no 16:0-LPC+blood 18:0/18:1-PE+blood 0 0 0.503589744 serum_phospholipids serum_phospholipids 0.00456 0.00716 up up no up up no 16:0-LPE+blood 18:0/18:1-PE+blood 0.521804511 0 0 serum_phospholipids serum_phospholipids 0.0711 0.00716 up up no up up no 16:0/14:0-PC+blood 18:0/18:1-PE+blood -0.521804511 0 -0.565811966 serum_phospholipids serum_phospholipids 0.0206 0.00716 no up up up up no 16:0/16:0-PI+blood 18:0/18:1-PE+blood 0.538345865 0.639705882 0 serum_phospholipids serum_phospholipids 0.358 0.00716 no no no up up no 16:0/16:1-PC+blood 18:0/18:1-PE+blood 0 0.583333333 0 serum_phospholipids serum_phospholipids 0.00283 0.00716 up up no up up no 16:0/16:1-PI+blood 18:0/18:1-PE+blood 0.490225564 0.568627451 0 serum_phospholipids serum_phospholipids 0.262 0.00716 no no no up up no 16:0/18:0-PS+blood 18:0/18:1-PE+blood 0.488721805 0 0 serum_phospholipids serum_phospholipids 0.377 0.00716 no no no up up no 16:0/18:1-PC+blood 18:0/18:1-PE+blood -0.595488722 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.00716 up up up up up no 16:0/18:1-PE+blood 18:0/18:1-PE+blood 0.77593985 0.629901961 0.416752137 serum_phospholipids serum_phospholipids 0.000107 0.00716 up up no up up no 16:0/18:2-PC+blood 18:0/18:1-PE+blood -0.639097744 0 -0.455726496 serum_phospholipids serum_phospholipids 3.24E-06 0.00716 no up up up up no 16:0/18:2-PI+blood 18:0/18:1-PE+blood 0.482706767 0.757352941 0 serum_phospholipids serum_phospholipids 0.269 0.00716 no no no up up no 16:0/20:3-PC+blood 18:0/18:1-PE+blood -0.640601504 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.00716 no up up up up no 16:0/20:4-PC+blood 18:0/18:1-PE+blood -0.505263158 -0.774509804 0 serum_phospholipids serum_phospholipids 0.0262 0.00716 no up no up up no 16:0/20:4-PE+blood 18:0/18:1-PE+blood 0.593984962 0 0 serum_phospholipids serum_phospholipids 0.00139 0.00716 up up no up up no 16:0/20:4-PI+blood 18:0/18:1-PE+blood 0.547368421 0 0 serum_phospholipids serum_phospholipids 0.558 0.00716 no no no up up no 16:0/22:6-PC+blood 18:0/18:1-PE+blood 0 -0.602941176 0 serum_phospholipids serum_phospholipids 4.53E-05 0.00716 no up up up up no 16:0/22:6-PE+blood 18:0/18:1-PE+blood 0.637593985 0 0 serum_phospholipids serum_phospholipids 0.000934 0.00716 up up no up up no 16:1/16:0-PC+blood 18:0/18:1-PE+blood -0.6 0 -0.507008547 serum_phospholipids serum_phospholipids 0.0215 0.00716 no up up up up no 16:1/16:1-PC+blood 18:0/18:1-PE+blood -0.520300752 0 -0.503589744 serum_phospholipids serum_phospholipids 0.0177 0.00716 no no up up up no 16:1/18:1-PG+blood 18:0/18:1-PE+blood -0.473684211 0 0 serum_phospholipids serum_phospholipids 3.21E-05 0.00716 no up up up up no 16:1/18:2-PG+blood 18:0/18:1-PE+blood -0.685714286 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.00716 no up up up up no 18:0-LPE+blood 18:0/18:1-PE+blood 0.612030075 0 0.44957265 serum_phospholipids serum_phospholipids 0.491 0.00716 no no no up up no 18:0/16:0-PC+blood 18:0/18:1-PE+blood -0.565413534 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.00716 up up up up up no 18:0/18:0-PE+blood 18:0/18:1-PE+blood 0.977443609 0.948529412 0.927521368 serum_phospholipids serum_phospholipids 0.00896 0.00716 up up no up up no AGE-RAGE signaling pathway in diabetic complications 18:0/18:1-PE+blood 0 0 0.410769231 kegg serum_phospholipids NA 0.00716 no no no up up no Alcoholism 18:0/18:1-PE+blood -0.456140351 0 0 kegg serum_phospholipids NA 0.00716 no no no up up no Asthma 18:0/18:1-PE+blood -0.471929825 0 0 kegg serum_phospholipids NA 0.00716 no no no up up no Clostridium 18:0/18:1-PE+blood 0 0.581585543 0 Genus serum_phospholipids 0.925 0.00716 no no no up up no DCA+stool 18:0/18:1-PE+blood 0 0 0.49924812 stool_bileacids serum_phospholipids 0.195 0.00716 no no no up up no FoxO signaling pathway 18:0/18:1-PE+blood 0 -0.505882353 0 kegg serum_phospholipids NA 0.00716 no no no up up no Glioma 18:0/18:1-PE+blood 0 0 0.407692308 kegg serum_phospholipids NA 0.00716 no no no up up no Inflammatory bowel disease 18:0/18:1-PE+blood -0.570175439 0 0 kegg serum_phospholipids NA 0.00716 no no no up up no Inflammatory mediator regulation of TRP channels 18:0/18:1-PE+blood 0 0 0.480769231 kegg serum_phospholipids NA 0.00716 no no no up up no Intestinal immune network for IgA production 18:0/18:1-PE+blood -0.642105263 0 0 kegg serum_phospholipids NA 0.00716 no no no up up no JAK-STAT signaling pathway 18:0/18:1-PE+blood 0 -0.5 0 kegg serum_phospholipids NA 0.00716 no no no up up no Lachnospira 18:0/18:1-PE+blood 0.503759398 0 0 butyrate-producing Genus serum_phospholipids 0.279 0.00716 no no no up up no LCA+stool 18:0/18:1-PE+blood 0 0 0.562406015 stool_bileacids serum_phospholipids 0.314 0.00716 no no no up up no MAPK signaling pathway 18:0/18:1-PE+blood 0 -0.514705882 0 kegg serum_phospholipids NA 0.00716 no no no up up no Melanogenesis 18:0/18:1-PE+blood 0 0 0.430769231 kegg serum_phospholipids NA 0.00716 no no no up up no Non-small cell lung cancer 18:0/18:1-PE+blood 0 -0.505882353 0 kegg serum_phospholipids NA 0.00716 no no no up up no Pancreatic cancer 18:0/18:1-PE+blood 0 0 0.472307692 kegg serum_phospholipids NA 0.00716 no no no up up no Prevotella 18:0/18:1-PE+blood 0.449779648 0 0 acetate-producing Genus serum_phospholipids 0.287 0.00716 no no no up up no Propionic acid+stool 18:0/18:1-PE+blood 0 0 0.503759398 yes stool_scfa serum_phospholipids 0.0436 0.00716 dn no up up up no Renin secretion 18:0/18:1-PE+blood 0 0 0.443846154 kegg serum_phospholipids NA 0.00716 no no no up up no Ruminococcus 18:0/18:1-PE+blood 0 0.550582568 0 Genus serum_phospholipids 0.0679 0.00716 no no dn up up no Small cell lung cancer 18:0/18:1-PE+blood 0 -0.529411765 0 kegg serum_phospholipids NA 0.00716 no no up up up no TCA+stool 18:0/18:1-PE+blood 0 0.7 0 stool_bileacids serum_phospholipids 0.458 0.00716 no no no up up no Tight junction 18:0/18:1-PE+blood 0 0.591176471 0 kegg serum_phospholipids NA 0.00716 no no no up up no Transcriptional misregulation in cancer 18:0/18:1-PE+blood 0 0 0.596153846 kegg serum_phospholipids NA 0.00716 no no no up up no Vascular smooth muscle contraction 18:0/18:1-PE+blood 0 0.514705882 0 kegg serum_phospholipids NA 0.00716 no no no up up no 13-HODE+blood 18:0/18:1-PG+blood 0 -0.669117647 0 serum_ARA serum_phospholipids 0.32 0.000842 no no no no up no 14:0+blood 18:0/18:1-PG+blood 0 0.588235294 0 yes serum_fattyacid serum_phospholipids 0.00572 0.000842 up no dn no up no 14:1/18:2-PG+blood 18:0/18:1-PG+blood 0 0 0.486495726 serum_phospholipids serum_phospholipids 0.00259 0.000842 no up up no up no 15-HETE+blood 18:0/18:1-PG+blood -0.453043304 0 0 serum_ARA serum_phospholipids 0.819 0.000842 no no no no up no 16:0/14:0-PC+blood 18:0/18:1-PG+blood 0 0 -0.511794872 serum_phospholipids serum_phospholipids 0.0206 0.000842 no up up no up no 16:0/18:0-PC+blood 18:0/18:1-PG+blood 0 0 -0.403760684 serum_phospholipids serum_phospholipids 0.521 0.000842 no no no no up no 16:0/18:0-PS+blood 18:0/18:1-PG+blood 0 0 0.628717949 serum_phospholipids serum_phospholipids 0.377 0.000842 no no no no up no 16:0/18:1-PE+blood 18:0/18:1-PG+blood 0.681203008 0 0 serum_phospholipids serum_phospholipids 0.000107 0.000842 up up no no up no 16:0/18:2-PC+blood 18:0/18:1-PG+blood 0 0 -0.457777778 serum_phospholipids serum_phospholipids 3.24E-06 0.000842 no up up no up no 16:0/20:4-PE+blood 18:0/18:1-PG+blood 0.77593985 0 0.403760684 serum_phospholipids serum_phospholipids 0.00139 0.000842 up up no no up no 16:0/20:4-PI+blood 18:0/18:1-PG+blood 0 0 0.401709402 serum_phospholipids serum_phospholipids 0.558 0.000842 no no no no up no 16:0/20:5-PG+blood 18:0/18:1-PG+blood 0 0 0.429059829 serum_phospholipids serum_phospholipids 0.00656 0.000842 no up no no up no 16:0/22:0-PE+blood 18:0/18:1-PG+blood 0 0 -0.544615385 serum_phospholipids serum_phospholipids 0.00839 0.000842 dn no up no up no 16:0/22:6-PC+blood 18:0/18:1-PG+blood 0 0 -0.433162393 serum_phospholipids serum_phospholipids 4.53E-05 0.000842 no up up no up no 16:0/22:6-PE+blood 18:0/18:1-PG+blood 0.508270677 0 0 serum_phospholipids serum_phospholipids 0.000934 0.000842 up up no no up no 16:1/18:1-PG+blood 18:0/18:1-PG+blood 0 0 0.483760684 serum_phospholipids serum_phospholipids 3.21E-05 0.000842 no up up no up no 16:1+blood 18:0/18:1-PG+blood 0 0.529411765 0 yes serum_fattyacid serum_phospholipids 0.0186 0.000842 no no dn no up no 18:0-LPE+blood 18:0/18:1-PG+blood 0.6 0 0 serum_phospholipids serum_phospholipids 0.491 0.000842 no no no no up no 18:0/18:0-PC+blood 18:0/18:1-PG+blood 0 0 -0.461196581 serum_phospholipids serum_phospholipids 0.426 0.000842 no no no no up no 18:0/18:0-PE+blood 18:0/18:1-PG+blood 0.508270677 0 0 serum_phospholipids serum_phospholipids 0.00896 0.000842 up up no no up no 18:0/18:0-PS+blood 18:0/18:1-PG+blood 0 0.50245098 0.621196581 serum_phospholipids serum_phospholipids 0.00617 0.000842 no up no no up no 18:0/18:1-PC+blood 18:0/18:1-PG+blood 0 0 -0.470769231 serum_phospholipids serum_phospholipids 0.393 0.000842 no no no no up no 18:0/18:1-PE+blood 18:0/18:1-PG+blood 0.536842105 0 0 serum_phospholipids serum_phospholipids 0.00716 0.000842 up up no no up no 11-HETE+blood 18:0/18:1-PI+blood 0 0.579312842 0 serum_ARA serum_phospholipids 0.464 0.599 no no no no no no 12-ketoDCA+blood 18:0/18:1-PI+blood 0 -0.576306805 0 serum_bileacids serum_phospholipids 0.517 0.599 no no no no no no 14:0/18:0-PC+blood 18:0/18:1-PI+blood 0 0.553921569 0 serum_phospholipids serum_phospholipids 0.00289 0.599 up up no no no no 15-HETE+blood 18:0/18:1-PI+blood -0.586380463 0 -0.41870555 serum_ARA serum_phospholipids 0.819 0.599 no no no no no no 16:0-LPC+blood 18:0/18:1-PI+blood 0 0 0.401709402 serum_phospholipids serum_phospholipids 0.00456 0.599 up up no no no no 16:0/16:0-PI+blood 18:0/18:1-PI+blood 0 0.56372549 0 serum_phospholipids serum_phospholipids 0.358 0.599 no no no no no no 16:0/16:1-PC+blood 18:0/18:1-PI+blood 0 0.575980392 0 serum_phospholipids serum_phospholipids 0.00283 0.599 up up no no no no 16:0/16:1-PI+blood 18:0/18:1-PI+blood 0 0.68627451 0 serum_phospholipids serum_phospholipids 0.262 0.599 no no no no no no 16:0/18:0-PC+blood 18:0/18:1-PI+blood 0.494736842 0 0 serum_phospholipids serum_phospholipids 0.521 0.599 no no no no no no 16:0/18:1-PE+blood 18:0/18:1-PI+blood 0 0.544117647 0 serum_phospholipids serum_phospholipids 0.000107 0.599 up up no no no no 16:0/20:4-PC+blood 18:0/18:1-PI+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 0.0262 0.599 no up no no no no 16:0/22:6-PC+blood 18:0/18:1-PI+blood 0 -0.5 0 serum_phospholipids serum_phospholipids 4.53E-05 0.599 no up up no no no 16:1/16:0-PC+blood 18:0/18:1-PI+blood 0 0 -0.467350427 serum_phospholipids serum_phospholipids 0.0215 0.599 no up up no no no 16:1/16:1-PC+blood 18:0/18:1-PI+blood 0 0 -0.485811966 serum_phospholipids serum_phospholipids 0.0177 0.599 no no up no no no 16:1/18:1-PG+blood 18:0/18:1-PI+blood 0 0.708333333 0 serum_phospholipids serum_phospholipids 3.21E-05 0.599 no up up no no no 18:0-LPA+blood 18:0/18:1-PI+blood 0 0 0.411282051 serum_phospholipids serum_phospholipids 0.0725 0.599 no dn no no no no 18:0-LPC+blood 18:0/18:1-PI+blood 0.485714286 0 0 serum_phospholipids serum_phospholipids 0.554 0.599 no no no no no no 18:0-LPE+blood 18:0/18:1-PI+blood 0.45112782 0 0 serum_phospholipids serum_phospholipids 0.491 0.599 no no no no no no 18:0/18:0-PC+blood 18:0/18:1-PI+blood 0.535338346 0 0 serum_phospholipids serum_phospholipids 0.426 0.599 no no no no no no 18:0/18:0-PE+blood 18:0/18:1-PI+blood 0 0.583333333 0 serum_phospholipids serum_phospholipids 0.00896 0.599 up up no no no no 18:0/18:1-PC+blood 18:0/18:1-PI+blood 0.551879699 0 0 serum_phospholipids serum_phospholipids 0.393 0.599 no no no no no no 18:0/18:1-PE+blood 18:0/18:1-PI+blood 0 0.541666667 0 serum_phospholipids serum_phospholipids 0.00716 0.599 up up no no no no 18:0/18:1-PG+blood 18:0/18:1-PI+blood 0.551879699 0 0 serum_phospholipids serum_phospholipids 0.000842 0.599 no up no no no no 16:0-LPE+blood 18:0/18:2-PC+blood -0.505263158 0 0 serum_phospholipids serum_phospholipids 0.0711 1.74E-06 up up no no up up 16:0/14:0-PC+blood 18:0/18:2-PC+blood 0.610526316 0.862745098 0.820854701 serum_phospholipids serum_phospholipids 0.0206 1.74E-06 no up up no up up 16:0/16:0-PC+blood 18:0/18:2-PC+blood 0.639097744 0.588235294 0.67042735 serum_phospholipids serum_phospholipids 0.00079 1.74E-06 no up up no up up 16:0/16:0-PI+blood 18:0/18:2-PC+blood -0.54887218 0 0 serum_phospholipids serum_phospholipids 0.358 1.74E-06 no no no no up up 16:0/16:1-PI+blood 18:0/18:2-PC+blood -0.672180451 0 0 serum_phospholipids serum_phospholipids 0.262 1.74E-06 no no no no up up 16:0/18:0-PC+blood 18:0/18:2-PC+blood 0 0 0.546666667 serum_phospholipids serum_phospholipids 0.521 1.74E-06 no no no no up up 16:0/18:0-PS+blood 18:0/18:2-PC+blood 0 0 -0.477606838 serum_phospholipids serum_phospholipids 0.377 1.74E-06 no no no no up up 16:0/18:1-PC+blood 18:0/18:2-PC+blood 0.8 0.825980392 0.598632479 serum_phospholipids serum_phospholipids 6.15E-07 1.74E-06 up up up no up up 16:0/18:1-PE+blood 18:0/18:2-PC+blood -0.587969925 0 0 serum_phospholipids serum_phospholipids 0.000107 1.74E-06 up up no no up up 16:0/18:2-PC+blood 18:0/18:2-PC+blood 0.896240602 0.796568627 0.831111111 serum_phospholipids serum_phospholipids 3.24E-06 1.74E-06 no up up no up up 16:0/20:3-PC+blood 18:0/18:2-PC+blood 0.77593985 0.691176471 0.493333333 serum_phospholipids serum_phospholipids 5.43E-06 1.74E-06 no up up no up up 16:0/20:4-PC+blood 18:0/18:2-PC+blood 0.539849624 0 0.574700855 serum_phospholipids serum_phospholipids 0.0262 1.74E-06 no up no no up up 16:0/20:4-PI+blood 18:0/18:2-PC+blood -0.610526316 -0.490196078 0 serum_phospholipids serum_phospholipids 0.558 1.74E-06 no no no no up up 16:0/22:0-PE+blood 18:0/18:2-PC+blood 0 0 0.475555556 serum_phospholipids serum_phospholipids 0.00839 1.74E-06 dn no up no up up 16:0/22:6-PC+blood 18:0/18:2-PC+blood 0.652631579 0 0.752478632 serum_phospholipids serum_phospholipids 4.53E-05 1.74E-06 no up up no up up 16:1-LPC+blood 18:0/18:2-PC+blood 0 -0.546568627 0 serum_phospholipids serum_phospholipids 0.0241 1.74E-06 no up no no up up 16:1/16:0-PC+blood 18:0/18:2-PC+blood 0.787969925 0 0.697777778 serum_phospholipids serum_phospholipids 0.0215 1.74E-06 no up up no up up 16:1/16:1-PC+blood 18:0/18:2-PC+blood 0.639097744 0 0.522735043 serum_phospholipids serum_phospholipids 0.0177 1.74E-06 no no up no up up 16:1/18:2-PG+blood 18:0/18:2-PC+blood 0.627067669 0 0 serum_phospholipids serum_phospholipids 1.40E-08 1.74E-06 no up up no up up 18:0-LPC+blood 18:0/18:2-PC+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.554 1.74E-06 no no no no up up 18:0-LPE+blood 18:0/18:2-PC+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.491 1.74E-06 no no no no up up 18:0/16:0-PC+blood 18:0/18:2-PC+blood 0.751879699 0.767156863 0.571965812 serum_phospholipids serum_phospholipids 9.64E-07 1.74E-06 up up up no up up 18:0/18:0-PE+blood 18:0/18:2-PC+blood -0.577443609 0 0 serum_phospholipids serum_phospholipids 0.00896 1.74E-06 up up no no up up 18:0/18:0-PS+blood 18:0/18:2-PC+blood 0 0 -0.459145299 serum_phospholipids serum_phospholipids 0.00617 1.74E-06 no up no no up up 18:0/18:1-PE+blood 18:0/18:2-PC+blood -0.57593985 0 -0.422905983 serum_phospholipids serum_phospholipids 0.00716 1.74E-06 up up no no up up 18:0/18:1-PG+blood 18:0/18:2-PC+blood 0 0 -0.6 serum_phospholipids serum_phospholipids 0.000842 1.74E-06 no up no no up up 18:0+blood 18:0/18:2-PC+blood 0 0 0.509059829 serum_fattyacid serum_phospholipids 0.344 1.74E-06 no no no no up up 3-(3-Hydroxyphenyl)propanoic acid+stool 18:0/18:2-PC+blood 0 0 -0.487218045 stool_cometabolism serum_phospholipids 0.33 1.74E-06 no no no no up up Adherens junction 18:0/18:2-PC+blood 0 0 -0.411538462 kegg serum_phospholipids NA 1.74E-06 no no no no up up Alzheimer disease 18:0/18:2-PC+blood 0 0 -0.501538462 kegg serum_phospholipids NA 1.74E-06 no no no no up up Amoebiasis 18:0/18:2-PC+blood 0.478947368 0 0 kegg serum_phospholipids NA 1.74E-06 no no no no up up Amyotrophic lateral sclerosis 18:0/18:2-PC+blood 0 0 -0.51 kegg serum_phospholipids NA 1.74E-06 no no no no up up Arrhythmogenic right ventricular cardiomyopathy 18:0/18:2-PC+blood 0 0 -0.422307692 kegg serum_phospholipids NA 1.74E-06 no up up no up up Butyricicoccus 18:0/18:2-PC+blood 0 0 -0.41794711 butyrate-producing Genus serum_phospholipids 0.852 1.74E-06 no no no no up up Cardiac muscle contraction 18:0/18:2-PC+blood 0 0 -0.565384615 kegg serum_phospholipids NA 1.74E-06 no no up no up up Central carbon metabolism in cancer 18:0/18:2-PC+blood 0 -0.541176471 0 kegg serum_phospholipids NA 1.74E-06 no no no no up up DCA+stool 18:0/18:2-PC+blood 0 0 -0.509774436 stool_bileacids serum_phospholipids 0.195 1.74E-06 no no no no up up Diabetic cardiomyopathy 18:0/18:2-PC+blood 0 0 -0.506923077 kegg serum_phospholipids NA 1.74E-06 no no no no up up Dilated cardiomyopathy 18:0/18:2-PC+blood 0 0 -0.413846154 kegg serum_phospholipids NA 1.74E-06 no up up no up up Focal adhesion 18:0/18:2-PC+blood 0 0 -0.446153846 kegg serum_phospholipids NA 1.74E-06 no up up no up up Fusobacterium 18:0/18:2-PC+blood 0 -0.647778583 0 Genus serum_phospholipids 0.628 1.74E-06 no no no no up up GCDCA+stool 18:0/18:2-PC+blood 0 0.609090909 0 yes stool_bileacids serum_phospholipids 0.0471 1.74E-06 no dn no no up up Hepatocellular carcinoma 18:0/18:2-PC+blood 0 0 -0.409230769 kegg serum_phospholipids NA 1.74E-06 no no no no up up Hippo signaling pathway 18:0/18:2-PC+blood 0 0 -0.468461538 kegg serum_phospholipids NA 1.74E-06 no no no no up up Huntington disease 18:0/18:2-PC+blood 0 0 -0.46 kegg serum_phospholipids NA 1.74E-06 no no no no up up Hypertrophic cardiomyopathy 18:0/18:2-PC+blood 0 0 -0.414615385 kegg serum_phospholipids NA 1.74E-06 no up up no up up Intestinal immune network for IgA production 18:0/18:2-PC+blood 0.503508772 0 0 kegg serum_phospholipids NA 1.74E-06 no no no no up up L-Phenylalanine+stool 18:0/18:2-PC+blood 0 0 0.467669173 stool_cometabolism serum_phospholipids 0.398 1.74E-06 no no no no up up L-Tyrosine+stool 18:0/18:2-PC+blood 0 0 0.476691729 stool_cometabolism serum_phospholipids 0.44 1.74E-06 no no no no up up Lachnospira 18:0/18:2-PC+blood 0 0 0.445206132 butyrate-producing Genus serum_phospholipids 0.279 1.74E-06 no no no no up up mTOR signaling pathway 18:0/18:2-PC+blood 0 0 0.486153846 kegg serum_phospholipids NA 1.74E-06 no no no no up up Non-alcoholic fatty liver disease 18:0/18:2-PC+blood 0 0 -0.456923077 kegg serum_phospholipids NA 1.74E-06 no no no no up up Oxidative phosphorylation 18:0/18:2-PC+blood 0 0 -0.480769231 kegg serum_phospholipids NA 1.74E-06 no no no no up up Phenylacetic acid+stool 18:0/18:2-PC+blood 0 -0.763636364 0 stool_cometabolism serum_phospholipids 0.785 1.74E-06 no no no no up up PI3K-Akt signaling pathway 18:0/18:2-PC+blood -0.484210526 0 0 yes kegg serum_phospholipids NA 1.74E-06 no up up no up up Prion disease 18:0/18:2-PC+blood 0 0 -0.56 kegg serum_phospholipids NA 1.74E-06 no no no no up up Propionic acid+stool 18:0/18:2-PC+blood 0 0 -0.461654135 yes stool_scfa serum_phospholipids 0.0436 1.74E-06 dn no up no up up Retrograde endocannabinoid signaling 18:0/18:2-PC+blood 0 0 -0.414615385 kegg serum_phospholipids NA 1.74E-06 no no up no up up Salivary secretion 18:0/18:2-PC+blood 0.550877193 0 0 kegg serum_phospholipids NA 1.74E-06 no no no no up up Thyroid hormone signaling pathway 18:0/18:2-PC+blood 0 0 -0.536923077 kegg serum_phospholipids NA 1.74E-06 no no no no up up 14:0-LPC+blood 18:0/18:2-PI+blood 0 0 0.424273504 serum_phospholipids serum_phospholipids 0.00689 0.179 up up no no no no 14:1/18:2-PG+blood 18:0/18:2-PI+blood 0 0 0.463247863 serum_phospholipids serum_phospholipids 0.00259 0.179 no up up no no no 16:0-LPC+blood 18:0/18:2-PI+blood 0 0 0.487179487 serum_phospholipids serum_phospholipids 0.00456 0.179 up up no no no no 16:0/16:0-PI+blood 18:0/18:2-PI+blood 0 0 0.486495726 serum_phospholipids serum_phospholipids 0.358 0.179 no no no no no no 16:0/16:1-PI+blood 18:0/18:2-PI+blood 0 0 0.412649573 serum_phospholipids serum_phospholipids 0.262 0.179 no no no no no no 16:0/18:2-PI+blood 18:0/18:2-PI+blood 0.481203008 0 0.53025641 serum_phospholipids serum_phospholipids 0.269 0.179 no no no no no no 16:0/20:4-PI+blood 18:0/18:2-PI+blood 0 0 0.505641026 serum_phospholipids serum_phospholipids 0.558 0.179 no no no no no no 16:0/20:5-PC+blood 18:0/18:2-PI+blood -0.496240602 0 0 serum_phospholipids serum_phospholipids 0.628 0.179 no no no no no no 16:1-LPC+blood 18:0/18:2-PI+blood 0 0 0.450940171 serum_phospholipids serum_phospholipids 0.0241 0.179 no up no no no no 16:1/18:2-PG+blood 18:0/18:2-PI+blood 0 0.651960784 0.446153846 serum_phospholipids serum_phospholipids 1.40E-08 0.179 no up up no no no 18:0-LPC+blood 18:0/18:2-PI+blood 0 0 0.45982906 serum_phospholipids serum_phospholipids 0.554 0.179 no no no no no no 18:0/18:1-PI+blood 18:0/18:2-PI+blood 0 0 0.697777778 serum_phospholipids serum_phospholipids 0.599 0.179 no no no no no no 4-hydroxybenzoic acid+stool 18:0/18:2-PI+blood 0.813186813 0 0 stool_cometabolism serum_phospholipids 0.0536 0.179 no dn no no no no ACA+stool 18:0/18:2-PI+blood -0.570087713 0 0 stool_bileacids serum_phospholipids 0.417 0.179 no no no no no no Adipocytokine signaling pathway 18:0/18:2-PI+blood -0.510526316 0 0 kegg serum_phospholipids NA 0.179 no no no no no no Akkermansia 18:0/18:2-PI+blood 0 0 -0.43528575 acetate-producing Genus serum_phospholipids 0.23 0.179 no no no no no no Antigen processing and presentation 18:0/18:2-PI+blood 0 0 -0.417692308 kegg serum_phospholipids NA 0.179 no no no no no no Apoptosis 18:0/18:2-PI+blood 0 0.511764706 0 kegg serum_phospholipids NA 0.179 no no no no no no Biosynthesis of amino acids 18:0/18:2-PI+blood 0 0 -0.407692308 kegg serum_phospholipids NA 0.179 no no no no no no Biosynthesis of cofactors 18:0/18:2-PI+blood 0 -0.552941176 0 kegg serum_phospholipids NA 0.179 no no no no no no C-type lectin receptor signaling pathway 18:0/18:2-PI+blood 0 0 0.401538462 kegg serum_phospholipids NA 0.179 no no no no no no Calcium signaling pathway 18:0/18:2-PI+blood 0 0 0.503076923 kegg serum_phospholipids NA 0.179 no up up no no no Carbon metabolism 18:0/18:2-PI+blood 0 0 -0.574615385 kegg serum_phospholipids NA 0.179 no no no no no no Chemokine signaling pathway 18:0/18:2-PI+blood 0 0.529411765 0 kegg serum_phospholipids NA 0.179 no no no no no no Chronic myeloid leukemia 18:0/18:2-PI+blood 0 0 0.490769231 kegg serum_phospholipids NA 0.179 no no no no no no Complement and coagulation cascades 18:0/18:2-PI+blood 0 0 -0.45 kegg serum_phospholipids NA 0.179 no no no no no no Cushing syndrome 18:0/18:2-PI+blood 0 0 0.461538462 kegg serum_phospholipids NA 0.179 no no up no no no Epithelial cell signaling in Helicobacter pylori infection 18:0/18:2-PI+blood 0 0.514705882 0 kegg serum_phospholipids NA 0.179 no no no no no no Fc gamma R-mediated phagocytosis 18:0/18:2-PI+blood 0 0 -0.510769231 kegg serum_phospholipids NA 0.179 no no no no no no Glutamatergic synapse 18:0/18:2-PI+blood -0.547368421 0 0 kegg serum_phospholipids NA 0.179 no up up no no no Glycolysis / Gluconeogenesis 18:0/18:2-PI+blood 0 0 -0.537692308 kegg serum_phospholipids NA 0.179 no no no no no no GnRH signaling pathway 18:0/18:2-PI+blood -0.468421053 0 0 kegg serum_phospholipids NA 0.179 no no no no no no Hepatitis B 18:0/18:2-PI+blood 0 0 0.585384615 kegg serum_phospholipids NA 0.179 no no no no no no Hepatitis C 18:0/18:2-PI+blood 0 0 0.533076923 kegg serum_phospholipids NA 0.179 no no no no no no Insulin resistance 18:0/18:2-PI+blood 0 0 0.672307692 kegg serum_phospholipids NA 0.179 no no no no no no Kaposi sarcoma-associated herpesvirus infection 18:0/18:2-PI+blood -0.612280702 0.523529412 0 kegg serum_phospholipids NA 0.179 no no dn no no no Long-term depression 18:0/18:2-PI+blood -0.577192982 0.514705882 0 kegg serum_phospholipids NA 0.179 no no no no no no Long-term potentiation 18:0/18:2-PI+blood 0 -0.579411765 0 kegg serum_phospholipids NA 0.179 no no up no no no Longevity regulating pathway 18:0/18:2-PI+blood -0.498245614 0 0 kegg serum_phospholipids NA 0.179 no no no no no no Longevity regulating pathway - multiple species 18:0/18:2-PI+blood 0.471929825 0 -0.508461538 kegg serum_phospholipids NA 0.179 no no no no no no Morphine addiction 18:0/18:2-PI+blood -0.564912281 0 0 kegg serum_phospholipids NA 0.179 no up up no no no Neurotrophin signaling pathway 18:0/18:2-PI+blood 0 0 0.500769231 kegg serum_phospholipids NA 0.179 no no no no no no NF-kappa B signaling pathway 18:0/18:2-PI+blood 0 0 0.492307692 kegg serum_phospholipids NA 0.179 no no no no no no Oxytocin signaling pathway 18:0/18:2-PI+blood 0 0 -0.488461538 kegg serum_phospholipids NA 0.179 no no no no no no Pathways in cancer 18:0/18:2-PI+blood 0 0 0.460769231 kegg serum_phospholipids NA 0.179 no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer 18:0/18:2-PI+blood 0 0 0.533076923 kegg serum_phospholipids NA 0.179 no no no no no no Pertussis 18:0/18:2-PI+blood 0 0 -0.402307692 kegg serum_phospholipids NA 0.179 no no dn no no no Phosphatidylinositol signaling system 18:0/18:2-PI+blood 0 -0.635294118 0 kegg serum_phospholipids NA 0.179 no no no no no no Primary immunodeficiency 18:0/18:2-PI+blood 0.626315789 0 0 kegg serum_phospholipids NA 0.179 no no no no no no Prostate cancer 18:0/18:2-PI+blood 0 0 0.624615385 kegg serum_phospholipids NA 0.179 no no no no no no Regulation of actin cytoskeleton 18:0/18:2-PI+blood 0 0 -0.454615385 kegg serum_phospholipids NA 0.179 no no no no no no Relaxin signaling pathway 18:0/18:2-PI+blood -0.528070175 0 0.418461538 kegg serum_phospholipids NA 0.179 no no no no no no Rheumatoid arthritis 18:0/18:2-PI+blood 0 0 -0.445384615 kegg serum_phospholipids NA 0.179 no no no no no no RIG-I-like receptor signaling pathway 18:0/18:2-PI+blood 0 0 0.583846154 kegg serum_phospholipids NA 0.179 no no no no no no Ruminococcus 18:0/18:2-PI+blood 0 0 0.428494654 Genus serum_phospholipids 0.0679 0.179 no no dn no no no Salmonella infection 18:0/18:2-PI+blood 0.577192982 0 0 kegg serum_phospholipids NA 0.179 no no no no no no Small cell lung cancer 18:0/18:2-PI+blood 0 0 0.538461538 kegg serum_phospholipids NA 0.179 no no up no no no Staphylococcus aureus infection 18:0/18:2-PI+blood 0 0 -0.475384615 kegg serum_phospholipids NA 0.179 up no no no no no Tight junction 18:0/18:2-PI+blood 0 0 -0.531538462 kegg serum_phospholipids NA 0.179 no no no no no no TNF signaling pathway 18:0/18:2-PI+blood 0 0 0.408461538 kegg serum_phospholipids NA 0.179 no no no no no no Transcriptional misregulation in cancer 18:0/18:2-PI+blood 0 0 0.491538462 kegg serum_phospholipids NA 0.179 no no no no no no Tuberculosis 18:0/18:2-PI+blood 0 0 -0.513076923 kegg serum_phospholipids NA 0.179 no no dn no no no Yersinia infection 18:0/18:2-PI+blood 0 0.547058824 0 kegg serum_phospholipids NA 0.179 no no no no no no 13-HODE+blood 18:0/20:2-PC+blood -0.446616541 0 0 serum_ARA serum_phospholipids 0.32 0.733 no no no no no no 14:0/18:0-PC+blood 18:0/20:2-PC+blood 0 0.544117647 0 serum_phospholipids serum_phospholipids 0.00289 0.733 up up no no no no 16:0/16:1-PC+blood 18:0/20:2-PC+blood 0 0.531862745 0 serum_phospholipids serum_phospholipids 0.00283 0.733 up up no no no no 16:0/16:1-PI+blood 18:0/20:2-PC+blood 0 0.568627451 0 serum_phospholipids serum_phospholipids 0.262 0.733 no no no no no no 16:0/18:0-PC+blood 18:0/20:2-PC+blood 0 0 0.61982906 serum_phospholipids serum_phospholipids 0.521 0.733 no no no no no no 16:0/18:0-PS+blood 18:0/20:2-PC+blood 0 0 -0.464615385 serum_phospholipids serum_phospholipids 0.377 0.733 no no no no no no 16:0/18:1-PE+blood 18:0/20:2-PC+blood 0 0 -0.517264957 serum_phospholipids serum_phospholipids 0.000107 0.733 up up no no no no 16:0/20:3-PC+blood 18:0/20:2-PC+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 5.43E-06 0.733 no up up no no no 16:0/20:4-PE+blood 18:0/20:2-PC+blood 0 0 -0.581538462 serum_phospholipids serum_phospholipids 0.00139 0.733 up up no no no no 16:0/22:0-PE+blood 18:0/20:2-PC+blood 0 0 0.424273504 serum_phospholipids serum_phospholipids 0.00839 0.733 dn no up no no no 16:0/22:6-PE+blood 18:0/20:2-PC+blood 0 0 -0.588376068 serum_phospholipids serum_phospholipids 0.000934 0.733 up up no no no no 18:0-LPC+blood 18:0/20:2-PC+blood 0 0 0.515213675 serum_phospholipids serum_phospholipids 0.554 0.733 no no no no no no 18:0/18:0-PC+blood 18:0/20:2-PC+blood 0.762406015 0.769607843 0.794871795 serum_phospholipids serum_phospholipids 0.426 0.733 no no no no no no 18:0/18:0-PE+blood 18:0/20:2-PC+blood 0.455639098 0 0 serum_phospholipids serum_phospholipids 0.00896 0.733 up up no no no no 18:0/18:0-PS+blood 18:0/20:2-PC+blood 0 0 -0.533675214 serum_phospholipids serum_phospholipids 0.00617 0.733 no up no no no no 18:0/18:1-PC+blood 18:0/20:2-PC+blood 0.744360902 0.75 0.79008547 serum_phospholipids serum_phospholipids 0.393 0.733 no no no no no no 18:0/18:1-PG+blood 18:0/20:2-PC+blood 0 0 -0.541880342 serum_phospholipids serum_phospholipids 0.000842 0.733 no up no no no no Axon guidance 18:0/20:2-PC+blood 0 0.535294118 0 kegg serum_phospholipids NA 0.733 no up up no no no Butyricicoccus 18:0/20:2-PC+blood 0.481701789 0 0 butyrate-producing Genus serum_phospholipids 0.852 0.733 no no no no no no Clostridium 18:0/20:2-PC+blood 0.46099336 0 -0.432196147 Genus serum_phospholipids 0.925 0.733 no no no no no no nutriCA+stool 18:0/20:2-PC+blood 0 0.706451749 0 stool_bileacids serum_phospholipids 0.481 0.733 no no no no no no Paraprevotella 18:0/20:2-PC+blood 0 0 0.46752173 Genus serum_phospholipids 0.118 0.733 no no no no no no Ruminococcus 18:0/20:2-PC+blood 0 0.593137255 0 acetate-producing Genus serum_phospholipids 0.335 0.733 no no no no no no "12,13-EPOME+blood" 18:0/20:3-PC+blood 0 0 -0.458528948 serum_ARA serum_phospholipids 0.901 0.0682 no no no no up no 14:0/16:0-PC+blood 18:0/20:3-PC+blood 0 0.490196078 0.416752137 serum_phospholipids serum_phospholipids 0.0358 0.0682 no up no no up no 14:0/18:0-PC+blood 18:0/20:3-PC+blood 0 0.720588235 0 serum_phospholipids serum_phospholipids 0.00289 0.0682 up up no no up no 14:0/18:2-PC+blood 18:0/20:3-PC+blood 0.631578947 0 0 serum_phospholipids serum_phospholipids 0.102 0.0682 no up no no up no 14:0/20:4-PC+blood 18:0/20:3-PC+blood 0.643609023 0 0 serum_phospholipids serum_phospholipids 0.486 0.0682 no no no no up no 16:0/16:0-PI+blood 18:0/20:3-PC+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 0.358 0.0682 no no no no up no 16:0/16:1-PC+blood 18:0/20:3-PC+blood 0 0.740196078 0 serum_phospholipids serum_phospholipids 0.00283 0.0682 up up no no up no 16:0/16:1-PI+blood 18:0/20:3-PC+blood 0 0.784313725 0 serum_phospholipids serum_phospholipids 0.262 0.0682 no no no no up no 16:0/18:2-PI+blood 18:0/20:3-PC+blood 0 0.512254902 0 serum_phospholipids serum_phospholipids 0.269 0.0682 no no no no up no 16:0/20:3-PC+blood 18:0/20:3-PC+blood 0 0.590686275 0.739487179 serum_phospholipids serum_phospholipids 5.43E-06 0.0682 no up up no up no 16:0/20:4-PI+blood 18:0/20:3-PC+blood 0 0.524509804 0 serum_phospholipids serum_phospholipids 0.558 0.0682 no no no no up no 18:0-LPC+blood 18:0/20:3-PC+blood 0.452631579 0 0 serum_phospholipids serum_phospholipids 0.554 0.0682 no no no no up no 18:0/18:0-PC+blood 18:0/20:3-PC+blood 0 0.850490196 0.534358974 serum_phospholipids serum_phospholipids 0.426 0.0682 no no no no up no 18:0/18:1-PC+blood 18:0/20:3-PC+blood 0 0.855392157 0.516581197 serum_phospholipids serum_phospholipids 0.393 0.0682 no no no no up no 18:0/18:1-PI+blood 18:0/20:3-PC+blood 0 0.546568627 0 serum_phospholipids serum_phospholipids 0.599 0.0682 no no no no up no 18:0/20:2-PC+blood 18:0/20:3-PC+blood 0.512781955 0.840686275 0.488547009 serum_phospholipids serum_phospholipids 0.733 0.0682 no no no no up no 18:0+blood 18:0/20:3-PC+blood 0.592481203 0 0 serum_fattyacid serum_phospholipids 0.344 0.0682 no no no no up no 3-(3-Hydroxyphenyl)propanoic acid+stool 18:0/20:3-PC+blood 0.604395604 0 0 stool_cometabolism serum_phospholipids 0.33 0.0682 no no no no up no Adipocytokine signaling pathway 18:0/20:3-PC+blood 0 0 0.55 kegg serum_phospholipids NA 0.0682 no no no no up no AMPK signaling pathway 18:0/20:3-PC+blood 0 0 0.403076923 kegg serum_phospholipids NA 0.0682 no no no no up no Arachidonic acid metabolism 18:0/20:3-PC+blood 0 0 0.404615385 kegg serum_phospholipids NA 0.0682 no no no no up no Biosynthesis of cofactors 18:0/20:3-PC+blood 0 0 0.425384615 kegg serum_phospholipids NA 0.0682 no no no no up no Central carbon metabolism in cancer 18:0/20:3-PC+blood 0 0 -0.461538462 kegg serum_phospholipids NA 0.0682 no no no no up no Clostridium 18:0/20:3-PC+blood 0.523505114 0.568976195 0 Genus serum_phospholipids 0.925 0.0682 no no no no up no Ferroptosis 18:0/20:3-PC+blood 0 0 0.535384615 kegg serum_phospholipids NA 0.0682 no no no no up no FoxO signaling pathway 18:0/20:3-PC+blood 0 0 -0.63 kegg serum_phospholipids NA 0.0682 no no no no up no Glioma 18:0/20:3-PC+blood 0 0 -0.402307692 kegg serum_phospholipids NA 0.0682 no no no no up no Glutathione metabolism 18:0/20:3-PC+blood 0 0 0.503846154 kegg serum_phospholipids NA 0.0682 no no no no up no "Glycine, serine and threonine metabolism" 18:0/20:3-PC+blood 0 0 0.462307692 kegg serum_phospholipids NA 0.0682 no up no no up no HDCA+stool 18:0/20:3-PC+blood 0 0 -0.49924812 stool_bileacids serum_phospholipids 0.176 0.0682 no no no no up no Kaposi sarcoma-associated herpesvirus infection 18:0/20:3-PC+blood 0 0 0.598461538 kegg serum_phospholipids NA 0.0682 no no dn no up no Longevity regulating pathway 18:0/20:3-PC+blood 0 0 0.437692308 kegg serum_phospholipids NA 0.0682 no no no no up no Mineral absorption 18:0/20:3-PC+blood 0 0 0.464615385 kegg serum_phospholipids NA 0.0682 no no no no up no Mitophagy - animal 18:0/20:3-PC+blood 0 0 0.409230769 kegg serum_phospholipids NA 0.0682 no no no no up no Necroptosis 18:0/20:3-PC+blood 0 0 0.405384615 kegg serum_phospholipids NA 0.0682 no no no no up no NOD-like receptor signaling pathway 18:0/20:3-PC+blood 0 -0.523529412 0 kegg serum_phospholipids NA 0.0682 no no no no up no nutriCA+stool 18:0/20:3-PC+blood 0 0.84407222 0 stool_bileacids serum_phospholipids 0.481 0.0682 no no no no up no Oocyte meiosis 18:0/20:3-PC+blood 0 0 -0.473846154 kegg serum_phospholipids NA 0.0682 no no no no up no Pathways of neurodegeneration - multiple diseases 18:0/20:3-PC+blood 0 0 0.42 kegg serum_phospholipids NA 0.0682 no no no no up no Phosphatidylinositol signaling system 18:0/20:3-PC+blood 0 0 -0.451538462 kegg serum_phospholipids NA 0.0682 no no no no up no Platinum drug resistance 18:0/20:3-PC+blood 0 0 -0.455384615 kegg serum_phospholipids NA 0.0682 no no no no up no Porphyrin and chlorophyll metabolism 18:0/20:3-PC+blood 0 0 0.488461538 kegg serum_phospholipids NA 0.0682 no no no no up no Primary immunodeficiency 18:0/20:3-PC+blood 0 0 -0.492307692 kegg serum_phospholipids NA 0.0682 no no no no up no Progesterone-mediated oocyte maturation 18:0/20:3-PC+blood 0 0 -0.488461538 kegg serum_phospholipids NA 0.0682 no no no no up no Purine metabolism 18:0/20:3-PC+blood 0 0 0.43 kegg serum_phospholipids NA 0.0682 no no no no up no Ruminococcus 18:0/20:3-PC+blood 0 0.629901961 0 acetate-producing Genus serum_phospholipids 0.335 0.0682 no no no no up no Shigellosis 18:0/20:3-PC+blood 0 0 0.446923077 kegg serum_phospholipids NA 0.0682 no no no no up no Sphingolipid signaling pathway 18:0/20:3-PC+blood 0 0 -0.486153846 kegg serum_phospholipids NA 0.0682 no no no no up no Spinocerebellar ataxia 18:0/20:3-PC+blood 0 0 -0.449230769 kegg serum_phospholipids NA 0.0682 no no no no up no Thyroid hormone synthesis 18:0/20:3-PC+blood 0 0 0.457692308 kegg serum_phospholipids NA 0.0682 no no no no up no 11-HETE+blood 18:0/20:3-PI+blood 0 0.553501874 0 serum_ARA serum_phospholipids 0.464 0.377 no no no no no no 12-ketoDCA+blood 18:0/20:3-PI+blood 0 -0.582893168 0 serum_bileacids serum_phospholipids 0.517 0.377 no no no no no no 13-HODE+blood 18:0/20:3-PI+blood 0.618045113 0 0 serum_ARA serum_phospholipids 0.32 0.377 no no no no no no 14:0-LPC+blood 18:0/20:3-PI+blood 0 0 0.463247863 serum_phospholipids serum_phospholipids 0.00689 0.377 up up no no no no 14:0/16:0-PC+blood 18:0/20:3-PI+blood 0 0.534313725 0 serum_phospholipids serum_phospholipids 0.0358 0.377 no up no no no no 14:0/18:0-PC+blood 18:0/20:3-PI+blood 0 0.625 0 serum_phospholipids serum_phospholipids 0.00289 0.377 up up no no no no 14:0+blood 18:0/20:3-PI+blood 0 0 0.405128205 yes serum_fattyacid serum_phospholipids 0.00572 0.377 up no dn no no no 14:1/18:2-PG+blood 18:0/20:3-PI+blood 0 0 0.555555556 serum_phospholipids serum_phospholipids 0.00259 0.377 no up up no no no 16:0-LPC+blood 18:0/20:3-PI+blood 0.491729323 0 0 serum_phospholipids serum_phospholipids 0.00456 0.377 up up no no no no 16:0/16:1-PC+blood 18:0/20:3-PI+blood 0 0.629901961 0 serum_phospholipids serum_phospholipids 0.00283 0.377 up up no no no no 16:0/16:1-PI+blood 18:0/20:3-PI+blood 0 0.571078431 0 serum_phospholipids serum_phospholipids 0.262 0.377 no no no no no no 16:0/18:1-PE+blood 18:0/20:3-PI+blood 0 0.625 0 serum_phospholipids serum_phospholipids 0.000107 0.377 up up no no no no 16:0/18:3-PC+blood 18:0/20:3-PI+blood 0 -0.522058824 0 serum_phospholipids serum_phospholipids 0.00216 0.377 no up up no no no 16:0/20:3-PC+blood 18:0/20:3-PI+blood 0 0.678921569 0 serum_phospholipids serum_phospholipids 5.43E-06 0.377 no up up no no no 16:0/20:4-PE+blood 18:0/20:3-PI+blood 0 0.534313725 0 serum_phospholipids serum_phospholipids 0.00139 0.377 up up no no no no 16:0/20:5-PC+blood 18:0/20:3-PI+blood -0.589473684 0 0 serum_phospholipids serum_phospholipids 0.628 0.377 no no no no no no 16:1/18:1-PG+blood 18:0/20:3-PI+blood 0.505263158 0.723039216 0 serum_phospholipids serum_phospholipids 3.21E-05 0.377 no up up no no no 16:1/18:2-PG+blood 18:0/20:3-PI+blood 0.529323308 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.377 no up up no no no 16:1+blood 18:0/20:3-PI+blood 0.466165414 0.487745098 0 yes serum_fattyacid serum_phospholipids 0.0186 0.377 no no dn no no no 18:0/18:1-PI+blood 18:0/20:3-PI+blood 0 0.693627451 0 serum_phospholipids serum_phospholipids 0.599 0.377 no no no no no no 18:0/20:3-PC+blood 18:0/20:3-PI+blood 0 0.625 0 serum_phospholipids serum_phospholipids 0.0682 0.377 no up no no no no Amoebiasis 18:0/20:3-PI+blood 0 0 -0.412307692 kegg serum_phospholipids NA 0.377 no no no no no no Antigen processing and presentation 18:0/20:3-PI+blood 0 0.611764706 0 kegg serum_phospholipids NA 0.377 no no no no no no CDCA+stool 18:0/20:3-PI+blood 0 0.709090909 0 stool_bileacids serum_phospholipids 0.663 0.377 no no no no no no Clostridium 18:0/20:3-PI+blood 0 0.597179757 0 Genus serum_phospholipids 0.925 0.377 no no no no no no Coronavirus disease - COVID-19 18:0/20:3-PI+blood 0 0 0.471538462 kegg serum_phospholipids NA 0.377 no no no no no no Epstein-Barr virus infection 18:0/20:3-PI+blood 0 0.676470588 0 kegg serum_phospholipids NA 0.377 no no no no no no GnRH signaling pathway 18:0/20:3-PI+blood 0 -0.605882353 0 kegg serum_phospholipids NA 0.377 no no no no no no Herpes simplex virus 1 infection 18:0/20:3-PI+blood 0 0.617647059 0 kegg serum_phospholipids NA 0.377 no no no no no no Human cytomegalovirus infection 18:0/20:3-PI+blood 0 0.608823529 0 kegg serum_phospholipids NA 0.377 no no dn no no no Human immunodeficiency virus 1 infection 18:0/20:3-PI+blood 0 0.65 0 kegg serum_phospholipids NA 0.377 no no no no no no Human T-cell leukemia virus 1 infection 18:0/20:3-PI+blood 0 0.614705882 0 kegg serum_phospholipids NA 0.377 no no no no no no MAPK signaling pathway 18:0/20:3-PI+blood 0 -0.517647059 0 kegg serum_phospholipids NA 0.377 no no no no no no Mitophagy - animal 18:0/20:3-PI+blood 0 0 0.406923077 kegg serum_phospholipids NA 0.377 no no no no no no nutriCA+stool 18:0/20:3-PI+blood 0 0.697277051 0 stool_bileacids serum_phospholipids 0.481 0.377 no no no no no no Pathways of neurodegeneration - multiple diseases 18:0/20:3-PI+blood 0 0 0.408461538 kegg serum_phospholipids NA 0.377 no no no no no no Ribosome 18:0/20:3-PI+blood 0 0 0.471538462 kegg serum_phospholipids NA 0.377 no no no no no no Sphingolipid signaling pathway 18:0/20:3-PI+blood 0 0.5 0 kegg serum_phospholipids NA 0.377 no no no no no no TCA+stool 18:0/20:3-PI+blood 0 0.627272727 0 stool_bileacids serum_phospholipids 0.458 0.377 no no no no no no Ubiquitin mediated proteolysis 18:0/20:3-PI+blood 0 0 0.408461538 kegg serum_phospholipids NA 0.377 no no no no no no UDCA+stool 18:0/20:3-PI+blood 0 0.709090909 0 stool_bileacids serum_phospholipids 0.266 0.377 no no no no no no Viral myocarditis 18:0/20:3-PI+blood 0 0.547058824 0 kegg serum_phospholipids NA 0.377 no no no no no no 14:0-LPC+blood 18:0/20:4-PC+blood 0 -0.482843137 0 serum_phospholipids serum_phospholipids 0.00689 0.454 up up no no no no 14:0/18:0-PC+blood 18:0/20:4-PC+blood 0 -0.683823529 0 serum_phospholipids serum_phospholipids 0.00289 0.454 up up no no no no 16:0-LPC+blood 18:0/20:4-PC+blood 0 0 -0.580854701 serum_phospholipids serum_phospholipids 0.00456 0.454 up up no no no no 16:0-LPE+blood 18:0/20:4-PC+blood -0.512781955 0 0 serum_phospholipids serum_phospholipids 0.0711 0.454 up up no no no no 16:0/14:0-PC+blood 18:0/20:4-PC+blood 0.603007519 0 0.561709402 serum_phospholipids serum_phospholipids 0.0206 0.454 no up up no no no 16:0/16:0-PC+blood 18:0/20:4-PC+blood 0.490225564 0 0.446153846 serum_phospholipids serum_phospholipids 0.00079 0.454 no up up no no no 16:0/16:0-PI+blood 18:0/20:4-PC+blood -0.589473684 -0.723039216 0 serum_phospholipids serum_phospholipids 0.358 0.454 no no no no no no 16:0/16:1-PC+blood 18:0/20:4-PC+blood 0 -0.681372549 0 serum_phospholipids serum_phospholipids 0.00283 0.454 up up no no no no 16:0/16:1-PI+blood 18:0/20:4-PC+blood -0.676691729 -0.610294118 0 serum_phospholipids serum_phospholipids 0.262 0.454 no no no no no no 16:0/18:1-PC+blood 18:0/20:4-PC+blood 0.721804511 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.454 up up up no no no 16:0/18:1-PE+blood 18:0/20:4-PC+blood -0.616541353 -0.676470588 0 serum_phospholipids serum_phospholipids 0.000107 0.454 up up no no no no 16:0/18:2-PC+blood 18:0/20:4-PC+blood 0.581954887 0 0.470769231 serum_phospholipids serum_phospholipids 3.24E-06 0.454 no up up no no no 16:0/18:2-PI+blood 18:0/20:4-PC+blood -0.622556391 -0.735294118 0 serum_phospholipids serum_phospholipids 0.269 0.454 no no no no no no 16:0/20:3-PC+blood 18:0/20:4-PC+blood 0.521804511 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.454 no up up no no no 16:0/20:4-PC+blood 18:0/20:4-PC+blood 0.932330827 0.862745098 0.915213675 serum_phospholipids serum_phospholipids 0.0262 0.454 no up no no no no 16:0/20:5-PC+blood 18:0/20:4-PC+blood 0 0.553921569 0 serum_phospholipids serum_phospholipids 0.628 0.454 no no no no no no 16:0/20:5-PG+blood 18:0/20:4-PC+blood 0.590977444 0 0 serum_phospholipids serum_phospholipids 0.00656 0.454 no up no no no no 16:0/22:0-PE+blood 18:0/20:4-PC+blood 0 0.514705882 0 serum_phospholipids serum_phospholipids 0.00839 0.454 dn no up no no no 16:0/22:6-PC+blood 18:0/20:4-PC+blood 0 0.901960784 0 serum_phospholipids serum_phospholipids 4.53E-05 0.454 no up up no no no 16:1/16:0-PC+blood 18:0/20:4-PC+blood 0.587969925 0.642156863 0.465299145 serum_phospholipids serum_phospholipids 0.0215 0.454 no up up no no no 16:1/16:1-PC+blood 18:0/20:4-PC+blood 0.685714286 0.512254902 0 serum_phospholipids serum_phospholipids 0.0177 0.454 no no up no no no 18:0-LPA+blood 18:0/20:4-PC+blood 0 0 -0.462564103 serum_phospholipids serum_phospholipids 0.0725 0.454 no dn no no no no 18:0/16:0-PC+blood 18:0/20:4-PC+blood 0.715789474 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.454 up up up no no no 18:0/18:0-PE+blood 18:0/20:4-PC+blood 0 -0.718137255 0 serum_phospholipids serum_phospholipids 0.00896 0.454 up up no no no no 18:0/18:1-PE+blood 18:0/20:4-PC+blood 0 -0.742647059 0 serum_phospholipids serum_phospholipids 0.00716 0.454 up up no no no no 18:0/18:1-PI+blood 18:0/20:4-PC+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.599 0.454 no no no no no no 18:0/18:2-PC+blood 18:0/20:4-PC+blood 0.514285714 0 0.546666667 serum_phospholipids serum_phospholipids 1.74E-06 0.454 no up up no no no 18:0+blood 18:0/20:4-PC+blood 0 0 0.456410256 serum_fattyacid serum_phospholipids 0.344 0.454 no no no no no no Asthma 18:0/20:4-PC+blood 0 0 -0.453076923 kegg serum_phospholipids NA 0.454 no no no no no no Autophagy - animal 18:0/20:4-PC+blood 0 0 0.425384615 kegg serum_phospholipids NA 0.454 no no no no no no Bacteroides 18:0/20:4-PC+blood 0 0.517156863 0 LPS-producing Genus serum_phospholipids 0.000267 0.454 dn dn up no no no Cholinergic synapse 18:0/20:4-PC+blood 0 0.526470588 0 kegg serum_phospholipids NA 0.454 no no no no no no Diabetic cardiomyopathy 18:0/20:4-PC+blood 0 0 -0.418461538 kegg serum_phospholipids NA 0.454 no no no no no no HCA+stool 18:0/20:4-PC+blood 0 0 -0.445112782 stool_bileacids serum_phospholipids 0.155 0.454 no no no no no no Inflammatory bowel disease 18:0/20:4-PC+blood 0 0 -0.476153846 kegg serum_phospholipids NA 0.454 no no no no no no Intestinal immune network for IgA production 18:0/20:4-PC+blood 0 0 -0.402307692 kegg serum_phospholipids NA 0.454 no no no no no no Kaposi sarcoma-associated herpesvirus infection 18:0/20:4-PC+blood 0 -0.611764706 0 kegg serum_phospholipids NA 0.454 no no dn no no no Lachnospira 18:0/20:4-PC+blood 0 0 0.489384279 butyrate-producing Genus serum_phospholipids 0.279 0.454 no no no no no no MAPK signaling pathway 18:0/20:4-PC+blood 0 0.576470588 0 kegg serum_phospholipids NA 0.454 no no no no no no Parabacteroides 18:0/20:4-PC+blood 0 0.549019608 0 Genus serum_phospholipids 4.19E-05 0.454 no up up no no no Prevotella 18:0/20:4-PC+blood -0.541432859 0 0 acetate-producing Genus serum_phospholipids 0.287 0.454 no no no no no no Prion disease 18:0/20:4-PC+blood 0 0 -0.417692308 kegg serum_phospholipids NA 0.454 no no no no no no Renal cell carcinoma 18:0/20:4-PC+blood 0 -0.5 0 kegg serum_phospholipids NA 0.454 no no no no no no Ruminococcus 18:0/20:4-PC+blood 0 -0.512569072 0 Genus serum_phospholipids 0.0679 0.454 no no dn no no no Shigellosis 18:0/20:4-PC+blood 0 -0.547058824 0 kegg serum_phospholipids NA 0.454 no no no no no no TCA+stool 18:0/20:4-PC+blood 0 -0.736363636 0 stool_bileacids serum_phospholipids 0.458 0.454 no no no no no no Th1 and Th2 cell differentiation 18:0/20:4-PC+blood 0.484210526 0 0 kegg serum_phospholipids NA 0.454 no no no no no no Th17 cell differentiation 18:0/20:4-PC+blood 0 0 -0.450769231 kegg serum_phospholipids NA 0.454 no no no no no no "12,13-EPOME+blood" 18:0/20:4-PI+blood 0 -0.521101993 0 serum_ARA serum_phospholipids 0.901 0.167 no no no no no no 14:0-LPC+blood 18:0/20:4-PI+blood -0.469172932 0 0 serum_phospholipids serum_phospholipids 0.00689 0.167 up up no no no no 14:1/18:2-PG+blood 18:0/20:4-PI+blood -0.505263158 0 0 serum_phospholipids serum_phospholipids 0.00259 0.167 no up up no no no 16:0/18:0-PS+blood 18:0/20:4-PI+blood 0 0.639705882 0.50017094 serum_phospholipids serum_phospholipids 0.377 0.167 no no no no no no 16:0/20:5-PG+blood 18:0/20:4-PI+blood 0.631578947 0.556372549 0.537094017 serum_phospholipids serum_phospholipids 0.00656 0.167 no up no no no no 16:1/16:1-PC+blood 18:0/20:4-PI+blood 0.553383459 0 0 serum_phospholipids serum_phospholipids 0.0177 0.167 no no up no no no 16:1/18:1-PG+blood 18:0/20:4-PI+blood 0.551879699 0 0.464615385 serum_phospholipids serum_phospholipids 3.21E-05 0.167 no up up no no no 16:1/18:2-PG+blood 18:0/20:4-PI+blood 0 0 0.481709402 serum_phospholipids serum_phospholipids 1.40E-08 0.167 no up up no no no 16:1+blood 18:0/20:4-PI+blood 0.470676692 0 0 yes serum_fattyacid serum_phospholipids 0.0186 0.167 no no dn no no no 18:0/18:0-PS+blood 18:0/20:4-PI+blood 0 0 0.546666667 serum_phospholipids serum_phospholipids 0.00617 0.167 no up no no no no 18:0/18:1-PG+blood 18:0/20:4-PI+blood 0 0 0.605470085 serum_phospholipids serum_phospholipids 0.000842 0.167 no up no no no no 18:0/18:2-PI+blood 18:0/20:4-PI+blood 0 0.490196078 0.472820513 serum_phospholipids serum_phospholipids 0.179 0.167 no no no no no no 18:0/20:3-PI+blood 18:0/20:4-PI+blood 0.720300752 0 0.504273504 serum_phospholipids serum_phospholipids 0.377 0.167 no no no no no no 18:0/20:4-PC+blood 18:0/20:4-PI+blood 0.452631579 0 0 serum_phospholipids serum_phospholipids 0.454 0.167 no no no no no no Amyotrophic lateral sclerosis 18:0/20:4-PI+blood 0 -0.514705882 0 kegg serum_phospholipids NA 0.167 no no no no no no Arachidonic acid metabolism 18:0/20:4-PI+blood 0 0 -0.400769231 kegg serum_phospholipids NA 0.167 no no no no no no Bifidobacterium 18:0/20:4-PI+blood 0 -0.589822306 0 acetate-producing Genus serum_phospholipids 0.105 0.167 no dn no no no no Biosynthesis of cofactors 18:0/20:4-PI+blood -0.529824561 0 0 kegg serum_phospholipids NA 0.167 no no no no no no Breast cancer 18:0/20:4-PI+blood 0 0.585294118 0.422307692 kegg serum_phospholipids NA 0.167 no no no no no no CA+stool 18:0/20:4-PI+blood 0 0 -0.520300752 stool_bileacids serum_phospholipids 0.827 0.167 no no no no no no cGMP-PKG signaling pathway 18:0/20:4-PI+blood 0.471929825 0 0 kegg serum_phospholipids NA 0.167 no no no no no no Collinsella 18:0/20:4-PI+blood 0 0 -0.532644831 Genus serum_phospholipids 0.128 0.167 no no no no no no Coprococcus 18:0/20:4-PI+blood 0 0 0.492649573 butyrate-producing Genus serum_phospholipids 0.612 0.167 no no no no no no DCA+stool 18:0/20:4-PI+blood 0 0 0.481203008 stool_bileacids serum_phospholipids 0.195 0.167 no no no no no no Fc gamma R-mediated phagocytosis 18:0/20:4-PI+blood 0.466666667 0 0 kegg serum_phospholipids NA 0.167 no no no no no no FoxO signaling pathway 18:0/20:4-PI+blood 0 0.635294118 0 kegg serum_phospholipids NA 0.167 no no no no no no Gap junction 18:0/20:4-PI+blood -0.524561404 0 0 kegg serum_phospholipids NA 0.167 no no no no no no "Glycine, serine and threonine metabolism" 18:0/20:4-PI+blood -0.58245614 0 0 kegg serum_phospholipids NA 0.167 no up no no no no HDCA+stool 18:0/20:4-PI+blood 0 0 0.547368421 stool_bileacids serum_phospholipids 0.176 0.167 no no no no no no iso-LCA+stool 18:0/20:4-PI+blood 0 0 0.458646617 stool_bileacids serum_phospholipids 0.72 0.167 no no no no no no Kaposi sarcoma-associated herpesvirus infection 18:0/20:4-PI+blood -0.603508772 0 0 kegg serum_phospholipids NA 0.167 no no dn no no no LCA+stool 18:0/20:4-PI+blood 0 0 0.544360902 stool_bileacids serum_phospholipids 0.314 0.167 no no no no no no Lipid and atherosclerosis 18:0/20:4-PI+blood 0.526315789 0 0 kegg serum_phospholipids NA 0.167 no no no no no no MAPK signaling pathway 18:0/20:4-PI+blood 0.457894737 0 0.483846154 kegg serum_phospholipids NA 0.167 no no no no no no Mitophagy - animal 18:0/20:4-PI+blood -0.564912281 -0.588235294 0 kegg serum_phospholipids NA 0.167 no no no no no no NOD-like receptor signaling pathway 18:0/20:4-PI+blood 0.580701754 0 0 kegg serum_phospholipids NA 0.167 no no no no no no Olfactory transduction 18:0/20:4-PI+blood 0.578947368 0 0 kegg serum_phospholipids NA 0.167 no no no no no no Parkinson disease 18:0/20:4-PI+blood 0 -0.55 0 kegg serum_phospholipids NA 0.167 no no no no no no Pathways of neurodegeneration - multiple diseases 18:0/20:4-PI+blood 0 -0.538235294 0 kegg serum_phospholipids NA 0.167 no no no no no no Peroxisome 18:0/20:4-PI+blood 0.459649123 0 0 kegg serum_phospholipids NA 0.167 no no no no no no Porphyrin and chlorophyll metabolism 18:0/20:4-PI+blood -0.542105263 -0.517647059 0 kegg serum_phospholipids NA 0.167 no no no no no no Progesterone-mediated oocyte maturation 18:0/20:4-PI+blood 0.478947368 0 0 kegg serum_phospholipids NA 0.167 no no no no no no Propionic acid+stool 18:0/20:4-PI+blood 0 0 0.482706767 yes stool_scfa serum_phospholipids 0.0436 0.167 dn no up no no no Proteoglycans in cancer 18:0/20:4-PI+blood -0.496491228 0 0 kegg serum_phospholipids NA 0.167 no no no no no no Renal cell carcinoma 18:0/20:4-PI+blood 0 0 0.435384615 kegg serum_phospholipids NA 0.167 no no no no no no Ruminococcus 18:0/20:4-PI+blood -0.451528109 0 0 Genus serum_phospholipids 0.0679 0.167 no no dn no no no Shigellosis 18:0/20:4-PI+blood -0.559649123 0 0 kegg serum_phospholipids NA 0.167 no no no no no no TCA+stool 18:0/20:4-PI+blood 0 0 -0.581954887 stool_bileacids serum_phospholipids 0.458 0.167 no no no no no no Thyroid hormone synthesis 18:0/20:4-PI+blood -0.58245614 0 0 kegg serum_phospholipids NA 0.167 no no no no no no Ubiquitin mediated proteolysis 18:0/20:4-PI+blood -0.536842105 -0.597058824 0 kegg serum_phospholipids NA 0.167 no no no no no no Vascular smooth muscle contraction 18:0/20:4-PI+blood 0 -0.617647059 0 kegg serum_phospholipids NA 0.167 no no no no no no 11-HETE+blood 18:0/20:5-PC+blood 0 -0.590784383 0 serum_ARA serum_phospholipids 0.464 0.17 no no no no no no 14:0/18:0-PC+blood 18:0/20:5-PC+blood 0 -0.818627451 0 serum_phospholipids serum_phospholipids 0.00289 0.17 up up no no no no 15-HETE+blood 18:0/20:5-PC+blood 0.569713318 0 0 serum_ARA serum_phospholipids 0.819 0.17 no no no no no no 16:0-LPC+blood 18:0/20:5-PC+blood 0 0 -0.532307692 serum_phospholipids serum_phospholipids 0.00456 0.17 up up no no no no 16:0/14:0-PC+blood 18:0/20:5-PC+blood 0 0 0.652649573 serum_phospholipids serum_phospholipids 0.0206 0.17 no up up no no no 16:0/16:0-PC+blood 18:0/20:5-PC+blood 0 0 0.45025641 serum_phospholipids serum_phospholipids 0.00079 0.17 no up up no no no 16:0/16:0-PI+blood 18:0/20:5-PC+blood -0.542857143 -0.720588235 0 serum_phospholipids serum_phospholipids 0.358 0.17 no no no no no no 16:0/16:1-PC+blood 18:0/20:5-PC+blood 0 -0.821078431 0 serum_phospholipids serum_phospholipids 0.00283 0.17 up up no no no no 16:0/16:1-PI+blood 18:0/20:5-PC+blood -0.589473684 -0.68627451 -0.548717949 serum_phospholipids serum_phospholipids 0.262 0.17 no no no no no no 16:0/18:0-PS+blood 18:0/20:5-PC+blood 0 0 -0.439316239 serum_phospholipids serum_phospholipids 0.377 0.17 no no no no no no 16:0/18:1-PC+blood 18:0/20:5-PC+blood 0.487218045 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.17 up up up no no no 16:0/18:1-PE+blood 18:0/20:5-PC+blood -0.565413534 -0.691176471 0 serum_phospholipids serum_phospholipids 0.000107 0.17 up up no no no no 16:0/18:2-PC+blood 18:0/20:5-PC+blood 0.52481203 0 0.491282051 serum_phospholipids serum_phospholipids 3.24E-06 0.17 no up up no no no 16:0/18:2-PI+blood 18:0/20:5-PC+blood -0.479699248 -0.767156863 0 serum_phospholipids serum_phospholipids 0.269 0.17 no no no no no no 16:0/20:3-PC+blood 18:0/20:5-PC+blood 0.460150376 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.17 no up up no no no 16:0/20:4-PC+blood 18:0/20:5-PC+blood 0 0.735294118 0.628717949 serum_phospholipids serum_phospholipids 0.0262 0.17 no up no no no no 16:0/20:5-PC+blood 18:0/20:5-PC+blood 0 0.487745098 0 serum_phospholipids serum_phospholipids 0.628 0.17 no no no no no no 16:0/22:0-PE+blood 18:0/20:5-PC+blood 0.568421053 0 0 serum_phospholipids serum_phospholipids 0.00839 0.17 dn no up no no no 16:0/22:6-PC+blood 18:0/20:5-PC+blood 0.631578947 0.779411765 0.410598291 serum_phospholipids serum_phospholipids 4.53E-05 0.17 no up up no no no 16:0+blood 18:0/20:5-PC+blood 0 0 -0.424957265 yes serum_fattyacid serum_phospholipids 0.00876 0.17 up no no no no no 16:1-LPC+blood 18:0/20:5-PC+blood 0 0 -0.562393162 serum_phospholipids serum_phospholipids 0.0241 0.17 no up no no no no 16:1/16:0-PC+blood 18:0/20:5-PC+blood 0 0.566176471 0.532991453 serum_phospholipids serum_phospholipids 0.0215 0.17 no up up no no no 16:1/18:1-PG+blood 18:0/20:5-PC+blood 0 0 -0.583589744 serum_phospholipids serum_phospholipids 3.21E-05 0.17 no up up no no no 16:1/18:2-PG+blood 18:0/20:5-PC+blood 0 -0.485294118 0 serum_phospholipids serum_phospholipids 1.40E-08 0.17 no up up no no no 18:0-LPA+blood 18:0/20:5-PC+blood 0 0 -0.582222222 serum_phospholipids serum_phospholipids 0.0725 0.17 no dn no no no no 18:0/16:0-PC+blood 18:0/20:5-PC+blood 0.45112782 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.17 up up up no no no 18:0/18:0-PE+blood 18:0/20:5-PC+blood 0 -0.725490196 0 serum_phospholipids serum_phospholipids 0.00896 0.17 up up no no no no 18:0/18:0-PS+blood 18:0/20:5-PC+blood 0 0 -0.40991453 serum_phospholipids serum_phospholipids 0.00617 0.17 no up no no no no 18:0/18:1-PE+blood 18:0/20:5-PC+blood 0 -0.723039216 0 serum_phospholipids serum_phospholipids 0.00716 0.17 up up no no no no 18:0/18:1-PI+blood 18:0/20:5-PC+blood 0 -0.669117647 -0.526837607 serum_phospholipids serum_phospholipids 0.599 0.17 no no no no no no 18:0/18:2-PC+blood 18:0/20:5-PC+blood 0.54887218 0 0.591111111 serum_phospholipids serum_phospholipids 1.74E-06 0.17 no up up no no no 18:0/20:3-PC+blood 18:0/20:5-PC+blood 0 -0.509803922 0 serum_phospholipids serum_phospholipids 0.0682 0.17 no up no no no no 18:0/20:4-PC+blood 18:0/20:5-PC+blood 0.520300752 0.901960784 0.673846154 serum_phospholipids serum_phospholipids 0.454 0.17 no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool 18:0/20:5-PC+blood 0 0 -0.484210526 stool_cometabolism serum_phospholipids 0.33 0.17 no no no no no no Acetic acid+stool 18:0/20:5-PC+blood -0.664835165 0 0 yes stool_scfa serum_phospholipids 0.0656 0.17 dn no no no no no Aldosterone synthesis and secretion 18:0/20:5-PC+blood 0 0 -0.513076923 kegg serum_phospholipids NA 0.17 no up up no no no Allograft rejection 18:0/20:5-PC+blood 0.619298246 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Alzheimer disease 18:0/20:5-PC+blood 0 0 -0.446153846 kegg serum_phospholipids NA 0.17 no no no no no no Amoebiasis 18:0/20:5-PC+blood 0.689473684 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Amphetamine addiction 18:0/20:5-PC+blood 0 0 -0.453846154 kegg serum_phospholipids NA 0.17 no no no no no no Apelin signaling pathway 18:0/20:5-PC+blood -0.528070175 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Arrhythmogenic right ventricular cardiomyopathy 18:0/20:5-PC+blood 0.464912281 0 0 kegg serum_phospholipids NA 0.17 no up up no no no Autoimmune thyroid disease 18:0/20:5-PC+blood 0.619298246 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Autophagy - animal 18:0/20:5-PC+blood 0 0 0.523076923 kegg serum_phospholipids NA 0.17 no no no no no no Axon guidance 18:0/20:5-PC+blood 0 -0.529411765 0 kegg serum_phospholipids NA 0.17 no up up no no no Biosynthesis of amino acids 18:0/20:5-PC+blood 0 0 0.440769231 kegg serum_phospholipids NA 0.17 no no no no no no Butyric acid+stool 18:0/20:5-PC+blood -0.598901099 0 0 yes stool_scfa serum_phospholipids 0.102 0.17 dn no no no no no CA+stool 18:0/20:5-PC+blood 0 0 -0.485714286 stool_bileacids serum_phospholipids 0.827 0.17 no no no no no no Calcium signaling pathway 18:0/20:5-PC+blood 0 0 -0.437692308 kegg serum_phospholipids NA 0.17 no up up no no no Carbon metabolism 18:0/20:5-PC+blood 0 0 0.503846154 kegg serum_phospholipids NA 0.17 no no no no no no Cardiac muscle contraction 18:0/20:5-PC+blood 0 0 -0.451538462 kegg serum_phospholipids NA 0.17 no no up no no no Cell adhesion molecules 18:0/20:5-PC+blood 0.624561404 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Cell cycle 18:0/20:5-PC+blood -0.563157895 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Cellular senescence 18:0/20:5-PC+blood 0.663157895 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Central carbon metabolism in cancer 18:0/20:5-PC+blood 0 0 0.44 kegg serum_phospholipids NA 0.17 no no no no no no Chemokine signaling pathway 18:0/20:5-PC+blood 0.571929825 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Cholinergic synapse 18:0/20:5-PC+blood 0 0.573529412 0 kegg serum_phospholipids NA 0.17 no no no no no no Cytosolic DNA-sensing pathway 18:0/20:5-PC+blood 0 0 -0.420769231 kegg serum_phospholipids NA 0.17 no no no no no no Diabetic cardiomyopathy 18:0/20:5-PC+blood 0 0 -0.466923077 kegg serum_phospholipids NA 0.17 no no no no no no Dilated cardiomyopathy 18:0/20:5-PC+blood 0.478947368 0 0 kegg serum_phospholipids NA 0.17 no up up no no no Dopaminergic synapse 18:0/20:5-PC+blood 0 0 -0.468461538 kegg serum_phospholipids NA 0.17 no up no no no no Endocytosis 18:0/20:5-PC+blood 0.680701754 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Epstein-Barr virus infection 18:0/20:5-PC+blood 0 -0.532352941 -0.411538462 kegg serum_phospholipids NA 0.17 no no no no no no Fc epsilon RI signaling pathway 18:0/20:5-PC+blood 0 0 0.413846154 kegg serum_phospholipids NA 0.17 no no no no no no FoxO signaling pathway 18:0/20:5-PC+blood 0 0 0.441538462 kegg serum_phospholipids NA 0.17 no no no no no no GCA+stool 18:0/20:5-PC+blood 0.664835165 0 0 stool_bileacids serum_phospholipids 0.0809 0.17 no no no no no no GCDCA+stool 18:0/20:5-PC+blood 0.593406593 0 0 yes stool_bileacids serum_phospholipids 0.0471 0.17 no dn no no no no GnRH signaling pathway 18:0/20:5-PC+blood 0 0 -0.403076923 kegg serum_phospholipids NA 0.17 no no no no no no Graft-versus-host disease 18:0/20:5-PC+blood 0.59122807 0 0 kegg serum_phospholipids NA 0.17 no no no no no no HCA+stool 18:0/20:5-PC+blood 0 0 -0.452631579 stool_bileacids serum_phospholipids 0.155 0.17 no no no no no no Hepatocellular carcinoma 18:0/20:5-PC+blood 0.489473684 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Herpes simplex virus 1 infection 18:0/20:5-PC+blood 0 0 -0.472307692 kegg serum_phospholipids NA 0.17 no no no no no no Human papillomavirus infection 18:0/20:5-PC+blood 0.731578947 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Human T-cell leukemia virus 1 infection 18:0/20:5-PC+blood 0 0 -0.451538462 kegg serum_phospholipids NA 0.17 no no no no no no Huntington disease 18:0/20:5-PC+blood 0 0 -0.442307692 kegg serum_phospholipids NA 0.17 no no no no no no Hypertrophic cardiomyopathy 18:0/20:5-PC+blood 0.487719298 0 0 kegg serum_phospholipids NA 0.17 no up up no no no Inflammatory mediator regulation of TRP channels 18:0/20:5-PC+blood 0 0 -0.404615385 kegg serum_phospholipids NA 0.17 no no no no no no Influenza A 18:0/20:5-PC+blood 0.577192982 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Insulin signaling pathway 18:0/20:5-PC+blood -0.550877193 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Kaposi sarcoma-associated herpesvirus infection 18:0/20:5-PC+blood 0 -0.714705882 0 kegg serum_phospholipids NA 0.17 no no dn no no no L-Tryptophan+stool 18:0/20:5-PC+blood 0.604395604 0 0 stool_cometabolism serum_phospholipids 0.557 0.17 no no no no no no Lachnospira 18:0/20:5-PC+blood 0 0 0.467808905 butyrate-producing Genus serum_phospholipids 0.279 0.17 no no no no no no Leukocyte transendothelial migration 18:0/20:5-PC+blood 0.575438596 0 0 kegg serum_phospholipids NA 0.17 no no no no no no MAPK signaling pathway 18:0/20:5-PC+blood 0 0.747058824 0 kegg serum_phospholipids NA 0.17 no no no no no no Melanogenesis 18:0/20:5-PC+blood 0 0 -0.421538462 kegg serum_phospholipids NA 0.17 no no no no no no Morphine addiction 18:0/20:5-PC+blood 0 0 -0.428461538 kegg serum_phospholipids NA 0.17 no up up no no no mTOR signaling pathway 18:0/20:5-PC+blood -0.5 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Natural killer cell mediated cytotoxicity 18:0/20:5-PC+blood 0.684210526 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Neutrophil extracellular trap formation 18:0/20:5-PC+blood 0.489473684 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Non-alcoholic fatty liver disease 18:0/20:5-PC+blood 0 -0.573529412 -0.492307692 kegg serum_phospholipids NA 0.17 no no no no no no Odoribacter 18:0/20:5-PC+blood -0.444335679 0 0 butyrate-producing Genus serum_phospholipids 0.798 0.17 no no no no no no Oocyte meiosis 18:0/20:5-PC+blood -0.49122807 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Oxidative phosphorylation 18:0/20:5-PC+blood 0 0 -0.470769231 kegg serum_phospholipids NA 0.17 no no no no no no p53 signaling pathway 18:0/20:5-PC+blood -0.524561404 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Pathogenic Escherichia coli infection 18:0/20:5-PC+blood 0.521052632 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Peroxisome 18:0/20:5-PC+blood 0 0 0.443846154 kegg serum_phospholipids NA 0.17 no no no no no no Phagosome 18:0/20:5-PC+blood 0.677192982 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Phospholipase D signaling pathway 18:0/20:5-PC+blood 0.566666667 0 0 kegg serum_phospholipids NA 0.17 no up up no no no PI3K-Akt signaling pathway 18:0/20:5-PC+blood -0.533333333 0 0 yes kegg serum_phospholipids NA 0.17 no up up no no no Prion disease 18:0/20:5-PC+blood 0 0 -0.522307692 kegg serum_phospholipids NA 0.17 no no no no no no Propionic acid+stool 18:0/20:5-PC+blood -0.571428571 0 0 yes stool_scfa serum_phospholipids 0.0436 0.17 dn no up no no no Protein processing in endoplasmic reticulum 18:0/20:5-PC+blood -0.471929825 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Rap1 signaling pathway 18:0/20:5-PC+blood 0.531578947 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Retrograde endocannabinoid signaling 18:0/20:5-PC+blood 0 0 -0.435384615 kegg serum_phospholipids NA 0.17 no no up no no no Ribosome biogenesis in eukaryotes 18:0/20:5-PC+blood -0.570175439 0 0 kegg serum_phospholipids NA 0.17 no no no no no no RNA degradation 18:0/20:5-PC+blood -0.494736842 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Ruminococcus 18:0/20:5-PC+blood 0 -0.631514527 0 Genus serum_phospholipids 0.0679 0.17 no no dn no no no Shigellosis 18:0/20:5-PC+blood 0 -0.611764706 0 kegg serum_phospholipids NA 0.17 no no no no no no Spliceosome 18:0/20:5-PC+blood -0.48245614 0 0 kegg serum_phospholipids NA 0.17 no no no no no no TCA+stool 18:0/20:5-PC+blood 0 -0.754545455 0 stool_bileacids serum_phospholipids 0.458 0.17 no no no no no no Thermogenesis 18:0/20:5-PC+blood 0 0 -0.533076923 kegg serum_phospholipids NA 0.17 no no no no no no Thyroid hormone signaling pathway 18:0/20:5-PC+blood 0.459649123 0 0 kegg serum_phospholipids NA 0.17 no no no no no no total_stool_scfa+stool 18:0/20:5-PC+blood -0.648351648 0 0 stool_scfa serum_phospholipids 0.0534 0.17 dn no up no no no Type I diabetes mellitus 18:0/20:5-PC+blood 0.619298246 0 0 kegg serum_phospholipids NA 0.17 no no no no no no UDCA+stool 18:0/20:5-PC+blood 0 0 -0.476691729 stool_bileacids serum_phospholipids 0.266 0.17 no no no no no no Viral carcinogenesis 18:0/20:5-PC+blood 0.768421053 0 0 kegg serum_phospholipids NA 0.17 no no no no no no Viral myocarditis 18:0/20:5-PC+blood 0.612280702 0 0 kegg serum_phospholipids NA 0.17 no no no no no no 16:0/16:0-PC+blood 18:0/22:6-PA+blood 0.45112782 0.546568627 0 serum_phospholipids serum_phospholipids 0.00079 0.22 no up up no no no 16:0/18:0-PC+blood 18:0/22:6-PA+blood 0.457142857 0.732843137 0 serum_phospholipids serum_phospholipids 0.521 0.22 no no no no no no 16:0/18:0-PS+blood 18:0/22:6-PA+blood 0 0.68627451 0 serum_phospholipids serum_phospholipids 0.377 0.22 no no no no no no 16:0/18:1-PC+blood 18:0/22:6-PA+blood 0.45112782 0.50245098 0 serum_phospholipids serum_phospholipids 6.15E-07 0.22 up up up no no no 16:0/20:5-PC+blood 18:0/22:6-PA+blood 0 0.5 0 serum_phospholipids serum_phospholipids 0.628 0.22 no no no no no no 16:0/20:5-PG+blood 18:0/22:6-PA+blood 0 0 0.477606838 serum_phospholipids serum_phospholipids 0.00656 0.22 no up no no no no 16:1/16:0-PC+blood 18:0/22:6-PA+blood 0.569924812 0 0 serum_phospholipids serum_phospholipids 0.0215 0.22 no up up no no no 16:1/16:1-PC+blood 18:0/22:6-PA+blood 0.619548872 0 0 serum_phospholipids serum_phospholipids 0.0177 0.22 no no up no no no 16:1/18:1-PG+blood 18:0/22:6-PA+blood 0.541353383 0 0.476923077 serum_phospholipids serum_phospholipids 3.21E-05 0.22 no up up no no no 16:1/18:2-PG+blood 18:0/22:6-PA+blood 0.452631579 0 0.577435897 serum_phospholipids serum_phospholipids 1.40E-08 0.22 no up up no no no 18:0/16:0-PC+blood 18:0/22:6-PA+blood 0.461654135 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.22 up up up no no no 18:0/18:0-PC+blood 18:0/22:6-PA+blood 0.485714286 0.600490196 0 serum_phospholipids serum_phospholipids 0.426 0.22 no no no no no no 18:0/18:0-PS+blood 18:0/22:6-PA+blood 0.562406015 0.590686275 0 serum_phospholipids serum_phospholipids 0.00617 0.22 no up no no no no 18:0/18:1-PC+blood 18:0/22:6-PA+blood 0.551879699 0.536764706 0 serum_phospholipids serum_phospholipids 0.393 0.22 no no no no no no 18:0/20:4-PI+blood 18:0/22:6-PA+blood 0 0.595588235 0 serum_phospholipids serum_phospholipids 0.167 0.22 no no no no no no Apelin signaling pathway 18:0/22:6-PA+blood 0 0 0.409230769 kegg serum_phospholipids NA 0.22 no no no no no no Apoptosis 18:0/22:6-PA+blood 0 0 -0.487692308 kegg serum_phospholipids NA 0.22 no no no no no no Biosynthesis of amino acids 18:0/22:6-PA+blood 0 0 -0.442307692 kegg serum_phospholipids NA 0.22 no no no no no no Calcium signaling pathway 18:0/22:6-PA+blood 0 -0.505882353 0 kegg serum_phospholipids NA 0.22 no up up no no no Fc gamma R-mediated phagocytosis 18:0/22:6-PA+blood 0 0 -0.403076923 kegg serum_phospholipids NA 0.22 no no no no no no GnRH signaling pathway 18:0/22:6-PA+blood 0 -0.5 0 kegg serum_phospholipids NA 0.22 no no no no no no Lipid and atherosclerosis 18:0/22:6-PA+blood 0 0 -0.439230769 kegg serum_phospholipids NA 0.22 no no no no no no Lysosome 18:0/22:6-PA+blood 0 0 -0.407692308 kegg serum_phospholipids NA 0.22 no no no no no no mRNA surveillance pathway 18:0/22:6-PA+blood 0 0 0.402307692 kegg serum_phospholipids NA 0.22 no no no no no no Neutrophil extracellular trap formation 18:0/22:6-PA+blood 0 0 -0.410769231 kegg serum_phospholipids NA 0.22 no no no no no no nutriCA+stool 18:0/22:6-PA+blood 0 0.651403561 0 stool_bileacids serum_phospholipids 0.481 0.22 no no no no no no Osteoclast differentiation 18:0/22:6-PA+blood 0 0 -0.456923077 kegg serum_phospholipids NA 0.22 no no no no no no Parabacteroides 18:0/22:6-PA+blood 0.484210526 0 0 Genus serum_phospholipids 4.19E-05 0.22 no up up no no no Paraprevotella 18:0/22:6-PA+blood 0 0 -0.44168631 Genus serum_phospholipids 0.118 0.22 no no no no no no Pertussis 18:0/22:6-PA+blood 0 0 -0.485384615 kegg serum_phospholipids NA 0.22 no no dn no no no Ribosome biogenesis in eukaryotes 18:0/22:6-PA+blood 0 0 0.441538462 kegg serum_phospholipids NA 0.22 no no no no no no Small cell lung cancer 18:0/22:6-PA+blood -0.457894737 0 0 kegg serum_phospholipids NA 0.22 no no up no no no Staphylococcus aureus infection 18:0/22:6-PA+blood 0 0 -0.536153846 kegg serum_phospholipids NA 0.22 up no no no no no Systemic lupus erythematosus 18:0/22:6-PA+blood 0 0 -0.410769231 kegg serum_phospholipids NA 0.22 no no no no no no Tuberculosis 18:0/22:6-PA+blood 0 0 -0.425384615 kegg serum_phospholipids NA 0.22 no no dn no no no 14:0/18:2-PC+blood 18:0/22:6-PC+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.102 0.0775 no up no no no up 14:0+blood 18:0/22:6-PC+blood 0.479699248 0 0 yes serum_fattyacid serum_phospholipids 0.00572 0.0775 up no dn no no up 14:1/18:2-PG+blood 18:0/22:6-PC+blood 0.497744361 0 0 serum_phospholipids serum_phospholipids 0.00259 0.0775 no up up no no up 16:0/14:0-PC+blood 18:0/22:6-PC+blood 0 0 0.42017094 serum_phospholipids serum_phospholipids 0.0206 0.0775 no up up no no up 16:0/18:2-PC+blood 18:0/22:6-PC+blood 0 0 0.578119658 serum_phospholipids serum_phospholipids 3.24E-06 0.0775 no up up no no up 16:0/20:5-PC+blood 18:0/22:6-PC+blood 0 0.553921569 0 serum_phospholipids serum_phospholipids 0.628 0.0775 no no no no no up 16:0/22:0-PE+blood 18:0/22:6-PC+blood 0.735338346 0.678921569 0.513162393 serum_phospholipids serum_phospholipids 0.00839 0.0775 dn no up no no up 16:0/22:6-PC+blood 18:0/22:6-PC+blood 0.821052632 0.784313725 0.824273504 serum_phospholipids serum_phospholipids 4.53E-05 0.0775 no up up no no up 16:1/16:0-PC+blood 18:0/22:6-PC+blood 0 0.740196078 0.649230769 serum_phospholipids serum_phospholipids 0.0215 0.0775 no up up no no up 18:0/18:0-PS+blood 18:0/22:6-PC+blood 0 0.482843137 0 serum_phospholipids serum_phospholipids 0.00617 0.0775 no up no no no up 18:0/18:2-PC+blood 18:0/22:6-PC+blood 0 0 0.532307692 serum_phospholipids serum_phospholipids 1.74E-06 0.0775 no up up no no up 18:0/20:4-PC+blood 18:0/22:6-PC+blood 0 0.602941176 0 serum_phospholipids serum_phospholipids 0.454 0.0775 no no no no no up 18:0/20:5-PC+blood 18:0/22:6-PC+blood 0.458646617 0.590686275 0.457777778 serum_phospholipids serum_phospholipids 0.17 0.0775 no no no no no up 3-(3-Hydroxyphenyl)propanoic acid+stool 18:0/22:6-PC+blood 0.71978022 0 0 stool_cometabolism serum_phospholipids 0.33 0.0775 no no no no no up AGE-RAGE signaling pathway in diabetic complications 18:0/22:6-PC+blood 0.557894737 0 0 kegg serum_phospholipids NA 0.0775 no no no no no up Alzheimer disease 18:0/22:6-PC+blood 0 0 -0.439230769 kegg serum_phospholipids NA 0.0775 no no no no no up Bacteroides 18:0/22:6-PC+blood 0 0.534313725 0 LPS-producing Genus serum_phospholipids 0.000267 0.0775 dn dn up no no up Blautia 18:0/22:6-PC+blood 0 0 -0.549231362 acetate-producing Genus serum_phospholipids 1.36E-05 0.0775 up dn dn no no up cAMP signaling pathway 18:0/22:6-PC+blood 0 -0.647058824 0 yes kegg serum_phospholipids NA 0.0775 no up up no no up Cardiac muscle contraction 18:0/22:6-PC+blood 0 0 -0.416153846 kegg serum_phospholipids NA 0.0775 no no up no no up Clostridium 18:0/22:6-PC+blood 0.522000789 0 0 Genus serum_phospholipids 0.925 0.0775 no no no no no up Ferroptosis 18:0/22:6-PC+blood 0 -0.514705882 0 kegg serum_phospholipids NA 0.0775 no no no no no up GnRH signaling pathway 18:0/22:6-PC+blood 0.473684211 0 0 kegg serum_phospholipids NA 0.0775 no no no no no up Huntington disease 18:0/22:6-PC+blood 0 0 -0.42 kegg serum_phospholipids NA 0.0775 no no no no no up Intestinal immune network for IgA production 18:0/22:6-PC+blood 0 0 -0.402307692 kegg serum_phospholipids NA 0.0775 no no no no no up Kaposi sarcoma-associated herpesvirus infection 18:0/22:6-PC+blood 0 -0.776470588 0 kegg serum_phospholipids NA 0.0775 no no dn no no up L-Tryptophan+stool 18:0/22:6-PC+blood 0 0 0.472180451 stool_cometabolism serum_phospholipids 0.557 0.0775 no no no no no up Malaria 18:0/22:6-PC+blood 0 -0.632352941 0 kegg serum_phospholipids NA 0.0775 no no no no no up Mineral absorption 18:0/22:6-PC+blood 0 -0.591176471 0 kegg serum_phospholipids NA 0.0775 no no no no no up Necroptosis 18:0/22:6-PC+blood 0 -0.676470588 0 kegg serum_phospholipids NA 0.0775 no no no no no up Peroxisome 18:0/22:6-PC+blood 0 0 0.408461538 kegg serum_phospholipids NA 0.0775 no no no no no up Prevotella 18:0/22:6-PC+blood -0.520988072 0 0 Genus serum_phospholipids 0.367 0.0775 no no no no no up Prion disease 18:0/22:6-PC+blood 0 0 -0.449230769 kegg serum_phospholipids NA 0.0775 no no no no no up Retrograde endocannabinoid signaling 18:0/22:6-PC+blood 0 0 -0.410769231 kegg serum_phospholipids NA 0.0775 no no up no no up Shigellosis 18:0/22:6-PC+blood 0 -0.588235294 0 kegg serum_phospholipids NA 0.0775 no no no no no up 12-ketoDCA+blood 18:0/22:6-PE+blood 0 -0.576306805 0 serum_bileacids serum_phospholipids 0.517 0.00022 no no no up up no 12-ketoDCA+stool 18:0/22:6-PE+blood 0 0 0.559398496 stool_bileacids serum_phospholipids 0.505 0.00022 no no no up up no 13-HODE+blood 18:0/22:6-PE+blood -0.45112782 0 0 serum_ARA serum_phospholipids 0.32 0.00022 no no no up up no 16:0-LPE+blood 18:0/22:6-PE+blood 0.563909774 0 0 serum_phospholipids serum_phospholipids 0.0711 0.00022 up up no up up no 16:0/16:0-PI+blood 18:0/22:6-PE+blood 0.523308271 0 0 serum_phospholipids serum_phospholipids 0.358 0.00022 no no no up up no 16:0/18:0-PS+blood 18:0/22:6-PE+blood 0.807518797 0.740196078 0.563760684 serum_phospholipids serum_phospholipids 0.377 0.00022 no no no up up no 16:0/18:1-PE+blood 18:0/22:6-PE+blood 0.615037594 0 0.746324786 serum_phospholipids serum_phospholipids 0.000107 0.00022 up up no up up no 16:0/20:3-PC+blood 18:0/22:6-PE+blood -0.482706767 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.00022 no up up up up no 16:0/20:4-PC+blood 18:0/22:6-PE+blood -0.466165414 0 0 serum_phospholipids serum_phospholipids 0.0262 0.00022 no up no up up no 16:0/20:4-PE+blood 18:0/22:6-PE+blood 0.631578947 0 0.744957265 serum_phospholipids serum_phospholipids 0.00139 0.00022 up up no up up no 16:0/20:5-PC+blood 18:0/22:6-PE+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 0.628 0.00022 no no no up up no 16:0/22:6-PE+blood 18:0/22:6-PE+blood 0.864661654 0.794117647 0.820854701 serum_phospholipids serum_phospholipids 0.000934 0.00022 up up no up up no 16:1+blood 18:0/22:6-PE+blood 0 0.490196078 0 yes serum_fattyacid serum_phospholipids 0.0186 0.00022 no no dn up up no 18:0-LPE+blood 18:0/22:6-PE+blood 0.621052632 0 0 serum_phospholipids serum_phospholipids 0.491 0.00022 no no no up up no 18:0/18:0-PE+blood 18:0/22:6-PE+blood 0.64962406 0 0 serum_phospholipids serum_phospholipids 0.00896 0.00022 up up no up up no 18:0/18:0-PS+blood 18:0/22:6-PE+blood 0.685714286 0.784313725 0.636923077 serum_phospholipids serum_phospholipids 0.00617 0.00022 no up no up up no 18:0/18:1-PE+blood 18:0/22:6-PE+blood 0.65112782 0 0 serum_phospholipids serum_phospholipids 0.00716 0.00022 up up no up up no 18:0/20:2-PC+blood 18:0/22:6-PE+blood 0 0 -0.463931624 serum_phospholipids serum_phospholipids 0.733 0.00022 no no no up up no 18:0/22:6-PC+blood 18:0/22:6-PE+blood 0 0.642156863 0.423589744 serum_phospholipids serum_phospholipids 0.0775 0.00022 no no up up up no Adipocytokine signaling pathway 18:0/22:6-PE+blood -0.524561404 -0.573529412 0 kegg serum_phospholipids NA 0.00022 no no no up up no Akkermansia 18:0/22:6-PE+blood 0 0 0.414823599 acetate-producing Genus serum_phospholipids 0.23 0.00022 no no no up up no Amoebiasis 18:0/22:6-PE+blood 0 0 0.404615385 kegg serum_phospholipids NA 0.00022 no no no up up no Asthma 18:0/22:6-PE+blood -0.645614035 0 -0.403846154 kegg serum_phospholipids NA 0.00022 no no no up up no Bacteroides 18:0/22:6-PE+blood 0 0.487745098 0 LPS-producing Genus serum_phospholipids 0.000267 0.00022 dn dn up up up no cAMP signaling pathway 18:0/22:6-PE+blood 0 -0.602941176 0 yes kegg serum_phospholipids NA 0.00022 no up up up up no cGMP-PKG signaling pathway 18:0/22:6-PE+blood 0 0 0.535384615 kegg serum_phospholipids NA 0.00022 no no no up up no Cholinergic synapse 18:0/22:6-PE+blood 0 0.508823529 0 kegg serum_phospholipids NA 0.00022 no no no up up no Chronic myeloid leukemia 18:0/22:6-PE+blood 0 -0.652941176 0 kegg serum_phospholipids NA 0.00022 no no no up up no Clostridium 18:0/22:6-PE+blood 0 0.586664893 0 Genus serum_phospholipids 0.925 0.00022 no no no up up no Cytosolic DNA-sensing pathway 18:0/22:6-PE+blood 0 -0.741176471 0 kegg serum_phospholipids NA 0.00022 no no no up up no Dorea 18:0/22:6-PE+blood 0 0 -0.414753727 Genus serum_phospholipids 0.00362 0.00022 up no dn up up no Epithelial cell signaling in Helicobacter pylori infection 18:0/22:6-PE+blood 0 0 0.465384615 kegg serum_phospholipids NA 0.00022 no no no up up no Estrogen signaling pathway 18:0/22:6-PE+blood 0.473684211 0 0 kegg serum_phospholipids NA 0.00022 no no no up up no Fc gamma R-mediated phagocytosis 18:0/22:6-PE+blood 0 0 0.427692308 kegg serum_phospholipids NA 0.00022 no no no up up no GCA+stool 18:0/22:6-PE+blood 0.681318681 0 0 stool_bileacids serum_phospholipids 0.0809 0.00022 no no no up up no GDCA+stool 18:0/22:6-PE+blood 0 0 -0.445783638 stool_bileacids serum_phospholipids 0.656 0.00022 no no no up up no Hematopoietic cell lineage 18:0/22:6-PE+blood 0 0 -0.439230769 kegg serum_phospholipids NA 0.00022 no no no up up no Hepatitis C 18:0/22:6-PE+blood 0 -0.755882353 0 kegg serum_phospholipids NA 0.00022 no no no up up no Human papillomavirus infection 18:0/22:6-PE+blood 0 0 0.451538462 kegg serum_phospholipids NA 0.00022 no no no up up no IL-17 signaling pathway 18:0/22:6-PE+blood 0 0 0.536153846 kegg serum_phospholipids NA 0.00022 no no no up up no Inflammatory bowel disease 18:0/22:6-PE+blood -0.663157895 0 0 kegg serum_phospholipids NA 0.00022 no no no up up no Insulin resistance 18:0/22:6-PE+blood 0 -0.567647059 0 kegg serum_phospholipids NA 0.00022 no no no up up no Intestinal immune network for IgA production 18:0/22:6-PE+blood -0.826315789 0 0 kegg serum_phospholipids NA 0.00022 no no no up up no Kaposi sarcoma-associated herpesvirus infection 18:0/22:6-PE+blood -0.485964912 -0.605882353 0 kegg serum_phospholipids NA 0.00022 no no dn up up no Lachnospira 18:0/22:6-PE+blood 0.565413534 0 0 butyrate-producing Genus serum_phospholipids 0.279 0.00022 no no no up up no Lipid and atherosclerosis 18:0/22:6-PE+blood 0 0 0.539230769 kegg serum_phospholipids NA 0.00022 no no no up up no Longevity regulating pathway - multiple species 18:0/22:6-PE+blood 0.545614035 0 0 kegg serum_phospholipids NA 0.00022 no no no up up no MAPK signaling pathway 18:0/22:6-PE+blood 0.503508772 0 0 kegg serum_phospholipids NA 0.00022 no no no up up no Measles 18:0/22:6-PE+blood 0 -0.55 0 kegg serum_phospholipids NA 0.00022 no no no up up no Neurotrophin signaling pathway 18:0/22:6-PE+blood 0 -0.608823529 0 kegg serum_phospholipids NA 0.00022 no no no up up no Olfactory transduction 18:0/22:6-PE+blood 0.470175439 0 0 kegg serum_phospholipids NA 0.00022 no no no up up no Osteoclast differentiation 18:0/22:6-PE+blood 0 0 0.428461538 kegg serum_phospholipids NA 0.00022 no no no up up no PD-L1 expression and PD-1 checkpoint pathway in cancer 18:0/22:6-PE+blood 0 -0.538235294 0 kegg serum_phospholipids NA 0.00022 no no no up up no Peroxisome 18:0/22:6-PE+blood 0 0 0.447692308 kegg serum_phospholipids NA 0.00022 no no no up up no Pertussis 18:0/22:6-PE+blood 0 0 0.431538462 kegg serum_phospholipids NA 0.00022 no no dn up up no Platinum drug resistance 18:0/22:6-PE+blood 0 0 -0.416923077 kegg serum_phospholipids NA 0.00022 no no no up up no PPAR signaling pathway 18:0/22:6-PE+blood 0 0 0.543846154 kegg serum_phospholipids NA 0.00022 no no no up up no Primary immunodeficiency 18:0/22:6-PE+blood 0.545614035 0 0 kegg serum_phospholipids NA 0.00022 no no no up up no Propionic acid+stool 18:0/22:6-PE+blood 0 0 0.515789474 yes stool_scfa serum_phospholipids 0.0436 0.00022 dn no up up up no Prostate cancer 18:0/22:6-PE+blood 0 -0.594117647 0 kegg serum_phospholipids NA 0.00022 no no no up up no Relaxin signaling pathway 18:0/22:6-PE+blood 0 -0.529411765 0 kegg serum_phospholipids NA 0.00022 no no no up up no Rheumatoid arthritis 18:0/22:6-PE+blood -0.457894737 0 0 kegg serum_phospholipids NA 0.00022 no no no up up no Small cell lung cancer 18:0/22:6-PE+blood 0 -0.582352941 0 kegg serum_phospholipids NA 0.00022 no no up up up no T cell receptor signaling pathway 18:0/22:6-PE+blood 0 -0.6 0 kegg serum_phospholipids NA 0.00022 no no no up up no Th1 and Th2 cell differentiation 18:0/22:6-PE+blood -0.656140351 0 -0.533076923 kegg serum_phospholipids NA 0.00022 no no no up up no Th17 cell differentiation 18:0/22:6-PE+blood -0.654385965 -0.576470588 -0.513076923 kegg serum_phospholipids NA 0.00022 no no no up up no TNF signaling pathway 18:0/22:6-PE+blood 0 -0.502941176 0 kegg serum_phospholipids NA 0.00022 no no no up up no Viral carcinogenesis 18:0/22:6-PE+blood 0 0 0.409230769 kegg serum_phospholipids NA 0.00022 no no no up up no 12-ketoDCA+blood 18:0/22:6-PI+blood 0 -0.559840896 0 serum_bileacids serum_phospholipids 0.517 0.425 no no no no no no 14:0/18:2-PC+blood 18:0/22:6-PI+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.102 0.425 no up no no no no 14:0+blood 18:0/22:6-PI+blood 0.57443609 0 0 yes serum_fattyacid serum_phospholipids 0.00572 0.425 up no dn no no no 15-HETE+blood 18:0/22:6-PI+blood 0 0 -0.416277266 serum_ARA serum_phospholipids 0.819 0.425 no no no no no no 16:0/16:0-PI+blood 18:0/22:6-PI+blood 0.633082707 0 0.469401709 serum_phospholipids serum_phospholipids 0.358 0.425 no no no no no no 16:0/18:0-PS+blood 18:0/22:6-PI+blood 0 0.718137255 0 serum_phospholipids serum_phospholipids 0.377 0.425 no no no no no no 16:0/18:2-PI+blood 18:0/22:6-PI+blood 0.621052632 0 0 serum_phospholipids serum_phospholipids 0.269 0.425 no no no no no no 16:0/20:4-PC+blood 18:0/22:6-PI+blood -0.478195489 0 -0.40034188 serum_phospholipids serum_phospholipids 0.0262 0.425 no up no no no no 16:0/20:4-PI+blood 18:0/22:6-PI+blood 0.545864662 0 0 serum_phospholipids serum_phospholipids 0.558 0.425 no no no no no no 16:0/22:0-PE+blood 18:0/22:6-PI+blood 0 0.549019608 0 serum_phospholipids serum_phospholipids 0.00839 0.425 dn no up no no no 16:0/22:6-PC+blood 18:0/22:6-PI+blood 0 0.549019608 0 serum_phospholipids serum_phospholipids 4.53E-05 0.425 no up up no no no 16:0/22:6-PE+blood 18:0/22:6-PI+blood 0 0.524509804 0 serum_phospholipids serum_phospholipids 0.000934 0.425 up up no no no no 16:1-LPC+blood 18:0/22:6-PI+blood 0 0 0.436581197 serum_phospholipids serum_phospholipids 0.0241 0.425 no up no no no no 16:1/16:0-PC+blood 18:0/22:6-PI+blood 0 0.546568627 0 serum_phospholipids serum_phospholipids 0.0215 0.425 no up up no no no 16:1/16:1-PC+blood 18:0/22:6-PI+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.0177 0.425 no no up no no no 18:0-LPC+blood 18:0/22:6-PI+blood 0.509774436 0 0 serum_phospholipids serum_phospholipids 0.554 0.425 no no no no no no 18:0-LPE+blood 18:0/22:6-PI+blood 0.45112782 0 0 serum_phospholipids serum_phospholipids 0.491 0.425 no no no no no no 18:0/18:0-PS+blood 18:0/22:6-PI+blood 0 0.674019608 0 serum_phospholipids serum_phospholipids 0.00617 0.425 no up no no no no 18:0/18:1-PI+blood 18:0/22:6-PI+blood 0 0 0.466666667 serum_phospholipids serum_phospholipids 0.599 0.425 no no no no no no 18:0/18:2-PI+blood 18:0/22:6-PI+blood 0 0 0.491282051 serum_phospholipids serum_phospholipids 0.179 0.425 no no no no no no 18:0/20:4-PI+blood 18:0/22:6-PI+blood 0 0.492647059 0 serum_phospholipids serum_phospholipids 0.167 0.425 no no no no no no 18:0/22:6-PA+blood 18:0/22:6-PI+blood 0 0.512254902 0.459145299 serum_phospholipids serum_phospholipids 0.22 0.425 no no no no no no 18:0/22:6-PC+blood 18:0/22:6-PI+blood 0.589473684 0.845588235 0 serum_phospholipids serum_phospholipids 0.0775 0.425 no no up no no no 18:0/22:6-PE+blood 18:0/22:6-PI+blood 0.55037594 0.803921569 0 serum_phospholipids serum_phospholipids 0.00022 0.425 up up no no no no 14:0/16:0-PC+blood 18:0+blood 0 0.482843137 0 serum_phospholipids serum_fattyacid 0.0358 0.344 no up no no no no 14:0/18:2-PC+blood 18:0+blood 0 0.524509804 0 serum_phospholipids serum_fattyacid 0.102 0.344 no up no no no no 14:0+blood 18:0+blood 0.565413534 0.504901961 0 yes serum_fattyacid serum_fattyacid 0.00572 0.344 up no dn no no no 16:0/14:0-PC+blood 18:0+blood 0 0 0.485128205 serum_phospholipids serum_fattyacid 0.0206 0.344 no up up no no no 16:0/16:0-PC+blood 18:0+blood 0 0 0.539145299 serum_phospholipids serum_fattyacid 0.00079 0.344 no up up no no no 16:0/20:4-PC+blood 18:0+blood 0 0 0.405128205 serum_phospholipids serum_fattyacid 0.0262 0.344 no up no no no no 16:0+blood 18:0+blood 0.714285714 0.517156863 0 yes serum_fattyacid serum_fattyacid 0.00876 0.344 up no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool 18:0+blood 0.686813187 0 0 stool_cometabolism serum_fattyacid 0.33 0.344 no no no no no no Acetic acid+stool 18:0+blood 0 -0.763636364 0 yes stool_scfa serum_fattyacid 0.0656 0.344 dn no no no no no Adherens junction 18:0+blood 0 0 -0.56 kegg serum_fattyacid NA 0.344 no no no no no no AGE-RAGE signaling pathway in diabetic complications 18:0+blood 0.554385965 0 0 kegg serum_fattyacid NA 0.344 no no no no no no Alzheimer disease 18:0+blood 0 0 -0.589230769 kegg serum_fattyacid NA 0.344 no no no no no no Amyotrophic lateral sclerosis 18:0+blood 0 0 -0.609230769 kegg serum_fattyacid NA 0.344 no no no no no no Arrhythmogenic right ventricular cardiomyopathy 18:0+blood 0 0 -0.557692308 kegg serum_fattyacid NA 0.344 no up up no no no Bacterial invasion of epithelial cells 18:0+blood 0 0 -0.553846154 kegg serum_fattyacid NA 0.344 no no no no no no Biosynthesis of cofactors 18:0+blood 0 0 0.406153846 kegg serum_fattyacid NA 0.344 no no no no no no Butyricimonas 18:0+blood 0 0.525712696 0 butyrate-producing Genus serum_fattyacid 0.17 0.344 no no no no no no Cardiac muscle contraction 18:0+blood 0 0 -0.621538462 kegg serum_fattyacid NA 0.344 no no up no no no Central carbon metabolism in cancer 18:0+blood 0.473684211 0 0 kegg serum_fattyacid NA 0.344 no no no no no no Chronic myeloid leukemia 18:0+blood 0 0 0.514615385 kegg serum_fattyacid NA 0.344 no no no no no no Collinsella 18:0+blood 0 0 -0.532644831 Genus serum_fattyacid 0.128 0.344 no no no no no no Cytokine-cytokine receptor interaction 18:0+blood 0 0 -0.476923077 kegg serum_fattyacid NA 0.344 no no no no no no Cytosolic DNA-sensing pathway 18:0+blood -0.571929825 0 0 kegg serum_fattyacid NA 0.344 no no no no no no Diabetic cardiomyopathy 18:0+blood 0 0 -0.629230769 kegg serum_fattyacid NA 0.344 no no no no no no Dilated cardiomyopathy 18:0+blood 0 0 -0.488461538 kegg serum_fattyacid NA 0.344 no up up no no no Focal adhesion 18:0+blood 0 0 -0.582307692 kegg serum_fattyacid NA 0.344 no up up no no no Gastric acid secretion 18:0+blood 0 0 -0.497692308 kegg serum_fattyacid NA 0.344 no no no no no no Glioma 18:0+blood 0.48245614 0 0 kegg serum_fattyacid NA 0.344 no no no no no no "Glycine, serine and threonine metabolism" 18:0+blood 0 0 0.420769231 kegg serum_fattyacid NA 0.344 no up no no no no Hepatitis B 18:0+blood 0 0 0.431538462 kegg serum_fattyacid NA 0.344 no no no no no no Hepatocellular carcinoma 18:0+blood 0 0 -0.450769231 kegg serum_fattyacid NA 0.344 no no no no no no Hippo signaling pathway 18:0+blood 0 0 -0.596153846 kegg serum_fattyacid NA 0.344 no no no no no no Huntington disease 18:0+blood 0 0 -0.623076923 kegg serum_fattyacid NA 0.344 no no no no no no Hypertrophic cardiomyopathy 18:0+blood 0 0 -0.538461538 kegg serum_fattyacid NA 0.344 no up up no no no Insulin resistance 18:0+blood 0 0 0.416153846 kegg serum_fattyacid NA 0.344 no no no no no no L-Phenylalanine+stool 18:0+blood 0 -0.645454545 0 stool_cometabolism serum_fattyacid 0.398 0.344 no no no no no no Lachnospira 18:0+blood 0 0 0.411986905 butyrate-producing Genus serum_fattyacid 0.279 0.344 no no no no no no NF-kappa B signaling pathway 18:0+blood 0 0 0.610769231 kegg serum_fattyacid NA 0.344 no no no no no no Non-alcoholic fatty liver disease 18:0+blood 0 0 -0.453846154 kegg serum_fattyacid NA 0.344 no no no no no no nutriCA+stool 18:0+blood 0 0 -0.445112782 stool_bileacids serum_fattyacid 0.481 0.344 no no no no no no Oxidative phosphorylation 18:0+blood 0 0 -0.623076923 kegg serum_fattyacid NA 0.344 no no no no no no Phenylacetic acid+stool 18:0+blood 0 -0.609090909 0 stool_cometabolism serum_fattyacid 0.785 0.344 no no no no no no Platelet activation 18:0+blood 0 0 -0.437692308 kegg serum_fattyacid NA 0.344 no no no no no no Prevotella 18:0+blood 0 0.556188795 0 acetate-producing Genus serum_fattyacid 0.287 0.344 no no no no no no Prion disease 18:0+blood 0 0 -0.667692308 kegg serum_fattyacid NA 0.344 no no no no no no Prolactin signaling pathway 18:0+blood 0 0 0.42 kegg serum_fattyacid NA 0.344 no no no no no no Purine metabolism 18:0+blood 0 0 0.417692308 kegg serum_fattyacid NA 0.344 no no no no no no Rap1 signaling pathway 18:0+blood 0 0 -0.444615385 kegg serum_fattyacid NA 0.344 no no no no no no Regulation of actin cytoskeleton 18:0+blood 0 0 -0.58 kegg serum_fattyacid NA 0.344 no no no no no no Retrograde endocannabinoid signaling 18:0+blood 0 0 -0.469230769 kegg serum_fattyacid NA 0.344 no no up no no no RIG-I-like receptor signaling pathway 18:0+blood 0 0 0.543076923 kegg serum_fattyacid NA 0.344 no no no no no no Small cell lung cancer 18:0+blood 0 0 0.426923077 kegg serum_fattyacid NA 0.344 no no up no no no Thermogenesis 18:0+blood 0 0 -0.553846154 kegg serum_fattyacid NA 0.344 no no no no no no Thyroid hormone signaling pathway 18:0+blood 0 0 -0.473076923 kegg serum_fattyacid NA 0.344 no no no no no no Tight junction 18:0+blood 0 0 -0.410769231 kegg serum_fattyacid NA 0.344 no no no no no no TNF signaling pathway 18:0+blood 0 0 0.476153846 kegg serum_fattyacid NA 0.344 no no no no no no total_stool_scfa+stool 18:0+blood 0 -0.681818182 0 stool_scfa serum_fattyacid 0.0534 0.344 dn no up no no no Viral protein interaction with cytokine and cytokine receptor 18:0+blood 0 0 -0.420769231 kegg serum_fattyacid NA 0.344 no no no no no no 12-ketoDCA+blood 18:1-LPC+blood -0.520550494 0 0 serum_bileacids serum_phospholipids 0.517 0.179 no no no no no no "12,13-EPOME+blood" 18:1-LPC+blood 0 -0.683946366 0 serum_ARA serum_phospholipids 0.901 0.179 no no no no no no 14:0-LPC+blood 18:1-LPC+blood -0.47518797 0 0 serum_phospholipids serum_phospholipids 0.00689 0.179 up up no no no no 14:0/16:0-PC+blood 18:1-LPC+blood -0.545864662 -0.566176471 0 serum_phospholipids serum_phospholipids 0.0358 0.179 no up no no no no 14:0/18:0-PC+blood 18:1-LPC+blood 0 -0.546568627 0 serum_phospholipids serum_phospholipids 0.00289 0.179 up up no no no no 14:0/20:4-PC+blood 18:1-LPC+blood -0.49924812 0 0 serum_phospholipids serum_phospholipids 0.486 0.179 no no no no no no 14:1/18:2-PG+blood 18:1-LPC+blood -0.562406015 0 0 serum_phospholipids serum_phospholipids 0.00259 0.179 no up up no no no 16:0/16:0-PI+blood 18:1-LPC+blood -0.460150376 0 -0.52957265 serum_phospholipids serum_phospholipids 0.358 0.179 no no no no no no 16:0/16:1-PC+blood 18:1-LPC+blood 0 -0.553921569 0 serum_phospholipids serum_phospholipids 0.00283 0.179 up up no no no no 16:0/16:1-PI+blood 18:1-LPC+blood -0.569924812 0 -0.403760684 serum_phospholipids serum_phospholipids 0.262 0.179 no no no no no no 16:0/18:0-PS+blood 18:1-LPC+blood 0 0 -0.408547009 serum_phospholipids serum_phospholipids 0.377 0.179 no no no no no no 16:0/18:1-PE+blood 18:1-LPC+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 0.000107 0.179 up up no no no no 16:0/18:2-PI+blood 18:1-LPC+blood -0.446616541 -0.615196078 0 serum_phospholipids serum_phospholipids 0.269 0.179 no no no no no no 16:0/20:4-PI+blood 18:1-LPC+blood -0.487218045 0 -0.414017094 serum_phospholipids serum_phospholipids 0.558 0.179 no no no no no no 16:0/20:5-PC+blood 18:1-LPC+blood -0.65112782 0 0 serum_phospholipids serum_phospholipids 0.628 0.179 no no no no no no 18:0-LPC+blood 18:1-LPC+blood 0 0 0.558290598 serum_phospholipids serum_phospholipids 0.554 0.179 no no no no no no 18:0/18:0-PC+blood 18:1-LPC+blood 0 0 0.485811966 serum_phospholipids serum_phospholipids 0.426 0.179 no no no no no no 18:0/18:0-PS+blood 18:1-LPC+blood 0 0 -0.414700855 serum_phospholipids serum_phospholipids 0.00617 0.179 no up no no no no 18:0/18:1-PC+blood 18:1-LPC+blood 0 0 0.499487179 serum_phospholipids serum_phospholipids 0.393 0.179 no no no no no no 18:0/18:1-PG+blood 18:1-LPC+blood 0 0 -0.539145299 serum_phospholipids serum_phospholipids 0.000842 0.179 no up no no no no 18:0/20:2-PC+blood 18:1-LPC+blood 0 0 0.631452991 serum_phospholipids serum_phospholipids 0.733 0.179 no no no no no no 18:0/20:4-PI+blood 18:1-LPC+blood 0.485714286 0 0 serum_phospholipids serum_phospholipids 0.167 0.179 no no no no no no 18:0/22:6-PE+blood 18:1-LPC+blood 0 -0.482843137 -0.405128205 serum_phospholipids serum_phospholipids 0.00022 0.179 up up no no no no Acetic acid+stool 18:1-LPC+blood 0 0.736363636 0 yes stool_scfa serum_phospholipids 0.0656 0.179 dn no no no no no Adlercreutzia 18:1-LPC+blood 0 0 0.529449482 Genus serum_phospholipids 0.548 0.179 no no no no no no Anaerostipes 18:1-LPC+blood -0.477756755 0 0 butyrate-producing Genus serum_phospholipids 0.568 0.179 no no no no no no Asthma 18:1-LPC+blood 0 0 0.413076923 kegg serum_phospholipids NA 0.179 no no no no no no B cell receptor signaling pathway 18:1-LPC+blood 0.566666667 0 0 kegg serum_phospholipids NA 0.179 no no no no no no Biosynthesis of cofactors 18:1-LPC+blood -0.645614035 0 -0.401538462 kegg serum_phospholipids NA 0.179 no no no no no no cAMP signaling pathway 18:1-LPC+blood 0.464912281 0 0 yes kegg serum_phospholipids NA 0.179 no up up no no no Cardiac muscle contraction 18:1-LPC+blood 0.507017544 0 0 kegg serum_phospholipids NA 0.179 no no up no no no Collinsella 18:1-LPC+blood -0.655121225 0 0 Genus serum_phospholipids 0.128 0.179 no no no no no no Coprococcus 18:1-LPC+blood -0.583458647 0 0 butyrate-producing Genus serum_phospholipids 0.612 0.179 no no no no no no Cytosolic DNA-sensing pathway 18:1-LPC+blood 0 0 -0.428461538 kegg serum_phospholipids NA 0.179 no no no no no no Diabetic cardiomyopathy 18:1-LPC+blood 0.480701754 0 0 kegg serum_phospholipids NA 0.179 no no no no no no Fc epsilon RI signaling pathway 18:1-LPC+blood 0.501754386 0 0 kegg serum_phospholipids NA 0.179 no no no no no no Gemmiger 18:1-LPC+blood 0 0 -0.44726093 butyrate-producing Genus serum_phospholipids 0.595 0.179 no no no no no no "Glycine, serine and threonine metabolism" 18:1-LPC+blood -0.654385965 0 0 kegg serum_phospholipids NA 0.179 no up no no no no HDCA+stool 18:1-LPC+blood 0 0 -0.631578947 stool_bileacids serum_phospholipids 0.176 0.179 no no no no no no Hematopoietic cell lineage 18:1-LPC+blood 0 0 0.476923077 kegg serum_phospholipids NA 0.179 no no no no no no Inflammatory bowel disease 18:1-LPC+blood 0 -0.517647059 0 kegg serum_phospholipids NA 0.179 no no no no no no Intestinal immune network for IgA production 18:1-LPC+blood 0 0 0.406923077 kegg serum_phospholipids NA 0.179 no no no no no no Lachnospira 18:1-LPC+blood -0.520300752 0 0 butyrate-producing Genus serum_phospholipids 0.279 0.179 no no no no no no Measles 18:1-LPC+blood 0 0 -0.413846154 kegg serum_phospholipids NA 0.179 no no no no no no Neurotrophin signaling pathway 18:1-LPC+blood 0.5 0 0 kegg serum_phospholipids NA 0.179 no no no no no no Pathways in cancer 18:1-LPC+blood 0 0.535294118 0 kegg serum_phospholipids NA 0.179 no no no no no no Phenylacetic acid+stool 18:1-LPC+blood 0.56043956 0 0 stool_cometabolism serum_phospholipids 0.785 0.179 no no no no no no Porphyrin and chlorophyll metabolism 18:1-LPC+blood -0.624561404 0 0 kegg serum_phospholipids NA 0.179 no no no no no no Purine metabolism 18:1-LPC+blood 0 0 -0.474615385 kegg serum_phospholipids NA 0.179 no no no no no no Ruminococcus 18:1-LPC+blood 0 -0.605763449 0 Genus serum_phospholipids 0.0679 0.179 no no dn no no no Sphingolipid signaling pathway 18:1-LPC+blood 0.528070175 0 0 kegg serum_phospholipids NA 0.179 no no no no no no Th1 and Th2 cell differentiation 18:1-LPC+blood 0.577192982 0 0 kegg serum_phospholipids NA 0.179 no no no no no no Th17 cell differentiation 18:1-LPC+blood 0.545614035 0 0 kegg serum_phospholipids NA 0.179 no no no no no no total_stool_scfa+stool 18:1-LPC+blood 0 0.772727273 0 stool_scfa serum_phospholipids 0.0534 0.179 dn no up no no no VEGF signaling pathway 18:1-LPC+blood 0.461403509 0 0 kegg serum_phospholipids NA 0.179 no no no no no no 16:0/18:1-PC+blood 18:1-LPE+blood -0.455639098 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.117 up up up no no no 16:0/18:2-PC+blood 18:1-LPE+blood -0.467669173 0 0 serum_phospholipids serum_phospholipids 3.24E-06 0.117 no up up no no no 16:0/20:4-PC+blood 18:1-LPE+blood -0.485714286 0 0 serum_phospholipids serum_phospholipids 0.0262 0.117 no up no no no no 16:0/20:5-PC+blood 18:1-LPE+blood 0 -0.593137255 0 serum_phospholipids serum_phospholipids 0.628 0.117 no no no no no no 16:0/22:0-PE+blood 18:1-LPE+blood -0.587969925 -0.49754902 0 serum_phospholipids serum_phospholipids 0.00839 0.117 dn no up no no no 16:0/22:6-PC+blood 18:1-LPE+blood -0.670676692 0 0 serum_phospholipids serum_phospholipids 4.53E-05 0.117 no up up no no no 16:0+blood 18:1-LPE+blood 0 0 -0.410598291 yes serum_fattyacid serum_phospholipids 0.00876 0.117 up no no no no no 16:1/16:0-PC+blood 18:1-LPE+blood -0.640601504 0 0 serum_phospholipids serum_phospholipids 0.0215 0.117 no up up no no no 16:1/16:1-PC+blood 18:1-LPE+blood -0.593984962 0 0 serum_phospholipids serum_phospholipids 0.0177 0.117 no no up no no no 18:0-LPE+blood 18:1-LPE+blood 0 0 0.446837607 serum_phospholipids serum_phospholipids 0.491 0.117 no no no no no no 18:0/16:0-PC+blood 18:1-LPE+blood -0.461654135 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.117 up up up no no no 18:0/18:1-PG+blood 18:1-LPE+blood 0 0 -0.433846154 serum_phospholipids serum_phospholipids 0.000842 0.117 no up no no no no 18:0/20:4-PC+blood 18:1-LPE+blood -0.530827068 0 0 serum_phospholipids serum_phospholipids 0.454 0.117 no no no no no no 18:0/20:4-PI+blood 18:1-LPE+blood 0 0 -0.513846154 serum_phospholipids serum_phospholipids 0.167 0.117 no no no no no no 18:0/20:5-PC+blood 18:1-LPE+blood -0.515789474 0 0 serum_phospholipids serum_phospholipids 0.17 0.117 no no no no no no 18:0/22:6-PA+blood 18:1-LPE+blood -0.529323308 0 0 serum_phospholipids serum_phospholipids 0.22 0.117 no no no no no no 18:0/22:6-PC+blood 18:1-LPE+blood -0.569924812 -0.522058824 0 serum_phospholipids serum_phospholipids 0.0775 0.117 no no up no no no 18:0/22:6-PI+blood 18:1-LPE+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.425 0.117 no no no no no no 18:1-LPC+blood 18:1-LPE+blood 0 0 0.656752137 serum_phospholipids serum_phospholipids 0.179 0.117 no no no no no no 4-hydroxybenzoic acid+stool 18:1-LPE+blood 0 0 0.542857143 stool_cometabolism serum_phospholipids 0.0536 0.117 no dn no no no no Arginine and proline metabolism 18:1-LPE+blood 0 0 -0.442307692 kegg serum_phospholipids NA 0.117 no up no no no no Bifidobacterium 18:1-LPE+blood -0.510718351 0 0 acetate-producing Genus serum_phospholipids 0.105 0.117 no dn no no no no Blautia 18:1-LPE+blood -0.446616541 0 0 acetate-producing Genus serum_phospholipids 1.36E-05 0.117 up dn dn no no no CDCA+stool 18:1-LPE+blood 0 0 0.517293233 stool_bileacids serum_phospholipids 0.663 0.117 no no no no no no HDCA+stool 18:1-LPE+blood 0 0 -0.598496241 stool_bileacids serum_phospholipids 0.176 0.117 no no no no no no iso-LCA+stool 18:1-LPE+blood 0 0 -0.470676692 stool_bileacids serum_phospholipids 0.72 0.117 no no no no no no nutriCA+stool 18:1-LPE+blood 0 0 0.554887218 stool_bileacids serum_phospholipids 0.481 0.117 no no no no no no Oscillospira 18:1-LPE+blood 0 0 -0.47965812 LPS-producing Genus serum_phospholipids 0.62 0.117 no no no no no no Paraprevotella 18:1-LPE+blood -0.449779648 0 0 Genus serum_phospholipids 0.118 0.117 no no no no no no Phenylacetic acid+stool 18:1-LPE+blood 0 0 -0.609022556 stool_cometabolism serum_phospholipids 0.785 0.117 no no no no no no Prevotella 18:1-LPE+blood 0.443839162 0 0 acetate-producing Genus serum_phospholipids 0.287 0.117 no no no no no no Purine metabolism 18:1-LPE+blood 0 0 -0.441538462 kegg serum_phospholipids NA 0.117 no no no no no no UDCA+stool 18:1-LPE+blood 0 0 0.446616541 stool_bileacids serum_phospholipids 0.266 0.117 no no no no no no 13-HODE+blood 18:1/16:0-PC+blood 0 0.56372549 0 serum_ARA serum_phospholipids 0.32 2.43E-05 no no no no up up 14:0/18:2-PC+blood 18:1/16:0-PC+blood 0 0 -0.48034188 serum_phospholipids serum_phospholipids 0.102 2.43E-05 no up no no up up 14:0/20:4-PC+blood 18:1/16:0-PC+blood 0 0 -0.63008547 serum_phospholipids serum_phospholipids 0.486 2.43E-05 no no no no up up 14:1/18:2-PG+blood 18:1/16:0-PC+blood 0 0 -0.457777778 serum_phospholipids serum_phospholipids 0.00259 2.43E-05 no up up no up up 16:0-LPE+blood 18:1/16:0-PC+blood -0.481203008 0 0 serum_phospholipids serum_phospholipids 0.0711 2.43E-05 up up no no up up 16:0/14:0-PC+blood 18:1/16:0-PC+blood 0.603007519 0.713235294 0.706666667 serum_phospholipids serum_phospholipids 0.0206 2.43E-05 no up up no up up 16:0/16:0-PC+blood 18:1/16:0-PC+blood 0.547368421 0.691176471 0.517948718 serum_phospholipids serum_phospholipids 0.00079 2.43E-05 no up up no up up 16:0/16:0-PI+blood 18:1/16:0-PC+blood -0.514285714 0 0 serum_phospholipids serum_phospholipids 0.358 2.43E-05 no no no no up up 16:0/16:1-PI+blood 18:1/16:0-PC+blood -0.554887218 0 0 serum_phospholipids serum_phospholipids 0.262 2.43E-05 no no no no up up 16:0/18:1-PC+blood 18:1/16:0-PC+blood 0.872180451 0.901960784 0.703931624 serum_phospholipids serum_phospholipids 6.15E-07 2.43E-05 up up up no up up 16:0/18:1-PE+blood 18:1/16:0-PC+blood -0.658646617 0 0 serum_phospholipids serum_phospholipids 0.000107 2.43E-05 up up no no up up 16:0/18:2-PC+blood 18:1/16:0-PC+blood 0.987969925 0.992647059 0.995897436 serum_phospholipids serum_phospholipids 3.24E-06 2.43E-05 no up up no up up 16:0/18:2-PI+blood 18:1/16:0-PC+blood -0.457142857 0 0 serum_phospholipids serum_phospholipids 0.269 2.43E-05 no no no no up up 16:0/20:3-PC+blood 18:1/16:0-PC+blood 0.67518797 0.509803922 0.450940171 serum_phospholipids serum_phospholipids 5.43E-06 2.43E-05 no up up no up up 16:0/20:4-PC+blood 18:1/16:0-PC+blood 0.676691729 0.5 0.552820513 serum_phospholipids serum_phospholipids 0.0262 2.43E-05 no up no no up up 16:0/20:4-PI+blood 18:1/16:0-PC+blood -0.49924812 -0.602941176 0 serum_phospholipids serum_phospholipids 0.558 2.43E-05 no no no no up up 16:0/22:6-PC+blood 18:1/16:0-PC+blood 0.615037594 0 0.744273504 serum_phospholipids serum_phospholipids 4.53E-05 2.43E-05 no up up no up up 16:1/16:0-PC+blood 18:1/16:0-PC+blood 0.813533835 0.637254902 0.80991453 serum_phospholipids serum_phospholipids 0.0215 2.43E-05 no up up no up up 16:1/16:1-PC+blood 18:1/16:0-PC+blood 0.590977444 0 0.556923077 serum_phospholipids serum_phospholipids 0.0177 2.43E-05 no no up no up up 16:1/18:2-PG+blood 18:1/16:0-PC+blood 0.595488722 0 0 serum_phospholipids serum_phospholipids 1.40E-08 2.43E-05 no up up no up up 18:0-LPC+blood 18:1/16:0-PC+blood 0 -0.649509804 0 serum_phospholipids serum_phospholipids 0.554 2.43E-05 no no no no up up 18:0-LPE+blood 18:1/16:0-PC+blood 0 -0.485294118 0 serum_phospholipids serum_phospholipids 0.491 2.43E-05 no no no no up up 18:0/16:0-PC+blood 18:1/16:0-PC+blood 0.843609023 0.904411765 0.703931624 serum_phospholipids serum_phospholipids 9.64E-07 2.43E-05 up up up no up up 18:0/18:0-PE+blood 18:1/16:0-PC+blood -0.652631579 0 -0.489230769 serum_phospholipids serum_phospholipids 0.00896 2.43E-05 up up no no up up 18:0/18:1-PE+blood 18:1/16:0-PC+blood -0.628571429 0 -0.460512821 serum_phospholipids serum_phospholipids 0.00716 2.43E-05 up up no no up up 18:0/18:1-PG+blood 18:1/16:0-PC+blood 0 0 -0.474188034 serum_phospholipids serum_phospholipids 0.000842 2.43E-05 no up no no up up 18:0/18:2-PC+blood 18:1/16:0-PC+blood 0.878195489 0.789215686 0.824957265 serum_phospholipids serum_phospholipids 1.74E-06 2.43E-05 no up up no up up 18:0/20:4-PC+blood 18:1/16:0-PC+blood 0.598496241 0 0.468717949 serum_phospholipids serum_phospholipids 0.454 2.43E-05 no no no no up up 18:0/20:5-PC+blood 18:1/16:0-PC+blood 0.533834586 0 0.511794872 serum_phospholipids serum_phospholipids 0.17 2.43E-05 no no no no up up 18:0/22:6-PC+blood 18:1/16:0-PC+blood 0 0 0.569230769 serum_phospholipids serum_phospholipids 0.0775 2.43E-05 no no up no up up 18:1-LPE+blood 18:1/16:0-PC+blood -0.506766917 0 0 serum_phospholipids serum_phospholipids 0.117 2.43E-05 no no no no up up Adrenergic signaling in cardiomyocytes 18:1/16:0-PC+blood 0 -0.597058824 0 kegg serum_phospholipids NA 2.43E-05 no no up no up up Aldosterone synthesis and secretion 18:1/16:0-PC+blood 0 0 -0.433846154 kegg serum_phospholipids NA 2.43E-05 no up up no up up Alistipes 18:1/16:0-PC+blood 0.495097865 -0.486817995 0 Genus serum_phospholipids 0.0114 2.43E-05 no up no no up up Alzheimer disease 18:1/16:0-PC+blood 0 0 -0.514615385 kegg serum_phospholipids NA 2.43E-05 no no no no up up AMPK signaling pathway 18:1/16:0-PC+blood 0 -0.611764706 0 kegg serum_phospholipids NA 2.43E-05 no no no no up up Amyotrophic lateral sclerosis 18:1/16:0-PC+blood 0 0 -0.577692308 kegg serum_phospholipids NA 2.43E-05 no no no no up up Blautia 18:1/16:0-PC+blood 0 0 -0.407206513 acetate-producing Genus serum_phospholipids 1.36E-05 2.43E-05 up dn dn no up up CA+stool 18:1/16:0-PC+blood -0.582417582 0 0 stool_bileacids serum_phospholipids 0.827 2.43E-05 no no no no up up Calcium signaling pathway 18:1/16:0-PC+blood 0 0 -0.415384615 kegg serum_phospholipids NA 2.43E-05 no up up no up up Cardiac muscle contraction 18:1/16:0-PC+blood 0 0 -0.546153846 kegg serum_phospholipids NA 2.43E-05 no no up no up up Cell cycle 18:1/16:0-PC+blood 0 -0.5 0 kegg serum_phospholipids NA 2.43E-05 no no no no up up Central carbon metabolism in cancer 18:1/16:0-PC+blood 0 -0.738235294 0 kegg serum_phospholipids NA 2.43E-05 no no no no up up Chemokine signaling pathway 18:1/16:0-PC+blood 0 0.523529412 0 kegg serum_phospholipids NA 2.43E-05 no no no no up up Diabetic cardiomyopathy 18:1/16:0-PC+blood 0 0 -0.49 kegg serum_phospholipids NA 2.43E-05 no no no no up up Dilated cardiomyopathy 18:1/16:0-PC+blood 0 0 -0.475384615 kegg serum_phospholipids NA 2.43E-05 no up up no up up EGFR tyrosine kinase inhibitor resistance 18:1/16:0-PC+blood 0 -0.570588235 0 kegg serum_phospholipids NA 2.43E-05 no no no no up up Endocrine and other factor-regulated calcium reabsorption 18:1/16:0-PC+blood 0 0 -0.433076923 kegg serum_phospholipids NA 2.43E-05 no no no no up up Fusobacterium 18:1/16:0-PC+blood 0 -0.556542163 0 Genus serum_phospholipids 0.628 2.43E-05 no no no no up up Gap junction 18:1/16:0-PC+blood 0 0 -0.476153846 kegg serum_phospholipids NA 2.43E-05 no no no no up up Gastric acid secretion 18:1/16:0-PC+blood 0 0 -0.418461538 kegg serum_phospholipids NA 2.43E-05 no no no no up up GCDCA+stool 18:1/16:0-PC+blood 0 0.609090909 0 yes stool_bileacids serum_phospholipids 0.0471 2.43E-05 no dn no no up up GDCA+stool 18:1/16:0-PC+blood -0.681318681 0 0 stool_bileacids serum_phospholipids 0.656 2.43E-05 no no no no up up Glucagon signaling pathway 18:1/16:0-PC+blood 0 -0.505882353 0 kegg serum_phospholipids NA 2.43E-05 no no no no up up Hippo signaling pathway 18:1/16:0-PC+blood 0 0 -0.441538462 kegg serum_phospholipids NA 2.43E-05 no no no no up up Huntington disease 18:1/16:0-PC+blood 0 0 -0.496153846 kegg serum_phospholipids NA 2.43E-05 no no no no up up IL-17 signaling pathway 18:1/16:0-PC+blood 0 0 0.504615385 kegg serum_phospholipids NA 2.43E-05 no no no no up up Inflammatory mediator regulation of TRP channels 18:1/16:0-PC+blood 0 -0.555882353 -0.469230769 kegg serum_phospholipids NA 2.43E-05 no no no no up up Insulin signaling pathway 18:1/16:0-PC+blood 0 -0.502941176 0 kegg serum_phospholipids NA 2.43E-05 no no no no up up Lachnospira 18:1/16:0-PC+blood 0 0 0.414726635 butyrate-producing Genus serum_phospholipids 0.279 2.43E-05 no no no no up up LCA+stool 18:1/16:0-PC+blood 0.56043956 0 0 stool_bileacids serum_phospholipids 0.314 2.43E-05 no no no no up up Lysosome 18:1/16:0-PC+blood 0 0 0.427692308 kegg serum_phospholipids NA 2.43E-05 no no no no up up mRNA surveillance pathway 18:1/16:0-PC+blood 0 -0.535294118 0 kegg serum_phospholipids NA 2.43E-05 no no no no up up mTOR signaling pathway 18:1/16:0-PC+blood 0 -0.591176471 0 kegg serum_phospholipids NA 2.43E-05 no no no no up up Non-alcoholic fatty liver disease 18:1/16:0-PC+blood 0 0 -0.594615385 kegg serum_phospholipids NA 2.43E-05 no no no no up up Oxidative phosphorylation 18:1/16:0-PC+blood 0 0 -0.476153846 kegg serum_phospholipids NA 2.43E-05 no no no no up up Pancreatic secretion 18:1/16:0-PC+blood 0 0 -0.487692308 kegg serum_phospholipids NA 2.43E-05 no no no no up up Peroxisome 18:1/16:0-PC+blood 0 0 0.440769231 kegg serum_phospholipids NA 2.43E-05 no no no no up up Phenylacetic acid+stool 18:1/16:0-PC+blood 0 -0.627272727 0 stool_cometabolism serum_phospholipids 0.785 2.43E-05 no no no no up up Prion disease 18:1/16:0-PC+blood 0 0 -0.498461538 kegg serum_phospholipids NA 2.43E-05 no no no no up up Proteasome 18:1/16:0-PC+blood 0 0 0.526153846 kegg serum_phospholipids NA 2.43E-05 no no no no up up Renal cell carcinoma 18:1/16:0-PC+blood 0 -0.526470588 0 kegg serum_phospholipids NA 2.43E-05 no no no no up up Retrograde endocannabinoid signaling 18:1/16:0-PC+blood 0 0 -0.407692308 kegg serum_phospholipids NA 2.43E-05 no no up no up up RNA transport 18:1/16:0-PC+blood 0 -0.576470588 0 kegg serum_phospholipids NA 2.43E-05 no no no no up up Ruminococcus 18:1/16:0-PC+blood 0 0 -0.428494654 Genus serum_phospholipids 0.0679 2.43E-05 no no dn no up up TCA+stool 18:1/16:0-PC+blood -0.594223396 0 0 stool_bileacids serum_phospholipids 0.458 2.43E-05 no no no no up up Th1 and Th2 cell differentiation 18:1/16:0-PC+blood 0 0.502941176 0 kegg serum_phospholipids NA 2.43E-05 no no no no up up Thermogenesis 18:1/16:0-PC+blood 0 0 -0.423076923 kegg serum_phospholipids NA 2.43E-05 no no no no up up Thyroid hormone signaling pathway 18:1/16:0-PC+blood 0 0 -0.493076923 kegg serum_phospholipids NA 2.43E-05 no no no no up up Toxoplasmosis 18:1/16:0-PC+blood 0 0.511764706 0 kegg serum_phospholipids NA 2.43E-05 no no no no up up Vasopressin-regulated water reabsorption 18:1/16:0-PC+blood 0 0 -0.477692308 kegg serum_phospholipids NA 2.43E-05 no no no no up up Yersinia infection 18:1/16:0-PC+blood 0 0.517647059 0 kegg serum_phospholipids NA 2.43E-05 no no no no up up 11-HETE+blood 18:1/16:0-PE+blood 0 0.610859581 0 serum_ARA serum_phospholipids 0.464 0.000182 no no no up up no 12-ketoDCA+blood 18:1/16:0-PE+blood 0 -0.573013623 0 serum_bileacids serum_phospholipids 0.517 0.000182 no no no up up no "12,13-EPOME+blood" 18:1/16:0-PE+blood 0 0.506070205 0 serum_ARA serum_phospholipids 0.901 0.000182 no no no up up no 13-HODE+blood 18:1/16:0-PE+blood -0.487218045 0 0 serum_ARA serum_phospholipids 0.32 0.000182 no no no up up no 14:0/18:0-PC+blood 18:1/16:0-PE+blood 0 0.612745098 0 serum_phospholipids serum_phospholipids 0.00289 0.000182 up up no up up no 14:0/20:4-PC+blood 18:1/16:0-PE+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.486 0.000182 no no no up up no 16:0-LPE+blood 18:1/16:0-PE+blood 0.682706767 0 0 serum_phospholipids serum_phospholipids 0.0711 0.000182 up up no up up no 16:0/16:0-PI+blood 18:1/16:0-PE+blood 0.559398496 0.558823529 0.442051282 serum_phospholipids serum_phospholipids 0.358 0.000182 no no no up up no 16:0/16:1-PC+blood 18:1/16:0-PE+blood 0 0.612745098 0 serum_phospholipids serum_phospholipids 0.00283 0.000182 up up no up up no 16:0/16:1-PI+blood 18:1/16:0-PE+blood 0.493233083 0.541666667 0.442051282 serum_phospholipids serum_phospholipids 0.262 0.000182 no no no up up no 16:0/18:0-PS+blood 18:1/16:0-PE+blood 0.580451128 0 0.437264957 serum_phospholipids serum_phospholipids 0.377 0.000182 no no no up up no 16:0/18:1-PC+blood 18:1/16:0-PE+blood -0.494736842 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.000182 up up up up up no 16:0/18:1-PE+blood 18:1/16:0-PE+blood 0.85112782 0.926470588 0.80991453 serum_phospholipids serum_phospholipids 0.000107 0.000182 up up no up up no 16:0/18:2-PC+blood 18:1/16:0-PE+blood -0.684210526 0 0 serum_phospholipids serum_phospholipids 3.24E-06 0.000182 no up up up up no 16:0/18:2-PI+blood 18:1/16:0-PE+blood 0 0.723039216 0 serum_phospholipids serum_phospholipids 0.269 0.000182 no no no up up no 16:0/20:3-PC+blood 18:1/16:0-PE+blood -0.739849624 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.000182 no up up up up no 16:0/20:4-PC+blood 18:1/16:0-PE+blood 0 -0.607843137 0 serum_phospholipids serum_phospholipids 0.0262 0.000182 no up no up up no 16:0/20:4-PE+blood 18:1/16:0-PE+blood 0.739849624 0.786764706 0.705982906 serum_phospholipids serum_phospholipids 0.00139 0.000182 up up no up up no 16:0/22:6-PC+blood 18:1/16:0-PE+blood -0.542857143 -0.575980392 0 serum_phospholipids serum_phospholipids 4.53E-05 0.000182 no up up up up no 16:0/22:6-PE+blood 18:1/16:0-PE+blood 0.666165414 0.482843137 0.76957265 serum_phospholipids serum_phospholipids 0.000934 0.000182 up up no up up no 16:1/16:0-PC+blood 18:1/16:0-PE+blood -0.514285714 0 0 serum_phospholipids serum_phospholipids 0.0215 0.000182 no up up up up no 16:1/18:1-PG+blood 18:1/16:0-PE+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 3.21E-05 0.000182 no up up up up no 16:1/18:2-PG+blood 18:1/16:0-PE+blood -0.560902256 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.000182 no up up up up no 16:1+blood 18:1/16:0-PE+blood 0 0.492647059 0 yes serum_fattyacid serum_phospholipids 0.0186 0.000182 no no dn up up no 18:0-LPE+blood 18:1/16:0-PE+blood 0.57593985 0 0.447521368 serum_phospholipids serum_phospholipids 0.491 0.000182 no no no up up no 18:0/16:0-PC+blood 18:1/16:0-PE+blood -0.460150376 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.000182 up up up up up no 18:0/18:0-PE+blood 18:1/16:0-PE+blood 0.803007519 0.654411765 0.658119658 serum_phospholipids serum_phospholipids 0.00896 0.000182 up up no up up no 18:0/18:0-PS+blood 18:1/16:0-PE+blood 0 0 0.48991453 serum_phospholipids serum_phospholipids 0.00617 0.000182 no up no up up no 18:0/18:1-PE+blood 18:1/16:0-PE+blood 0.827067669 0.740196078 0.738803419 serum_phospholipids serum_phospholipids 0.00716 0.000182 up up no up up no 18:0/18:1-PG+blood 18:1/16:0-PE+blood 0.556390977 0 0.503589744 serum_phospholipids serum_phospholipids 0.000842 0.000182 no up no up up no 18:0/18:1-PI+blood 18:1/16:0-PE+blood 0 0.578431373 0 serum_phospholipids serum_phospholipids 0.599 0.000182 no no no up up no 18:0/18:2-PC+blood 18:1/16:0-PE+blood -0.646616541 0 0 serum_phospholipids serum_phospholipids 1.74E-06 0.000182 no up up up up no 18:0/20:2-PC+blood 18:1/16:0-PE+blood 0 0 -0.417435897 serum_phospholipids serum_phospholipids 0.733 0.000182 no no no up up no 18:0/20:4-PC+blood 18:1/16:0-PE+blood 0 -0.647058824 0 serum_phospholipids serum_phospholipids 0.454 0.000182 no no no up up no 18:0/20:5-PC+blood 18:1/16:0-PE+blood -0.529323308 -0.644607843 0 serum_phospholipids serum_phospholipids 0.17 0.000182 no no no up up no 18:0/22:6-PE+blood 18:1/16:0-PE+blood 0.545864662 0 0.605470085 serum_phospholipids serum_phospholipids 0.00022 0.000182 up up no up up no 18:1/16:0-PC+blood 18:1/16:0-PE+blood -0.670676692 0 0 serum_phospholipids serum_phospholipids 2.43E-05 0.000182 no up up up up no 11-HETE+blood 18:1/16:0-PI+blood 0 0.487540511 0 serum_ARA serum_phospholipids 0.464 0.793 no no no no no no 14:0-LPC+blood 18:1/16:0-PI+blood 0 0 0.562393162 serum_phospholipids serum_phospholipids 0.00689 0.793 up up no no no no 14:0/16:0-PC+blood 18:1/16:0-PI+blood 0 0 0.550769231 serum_phospholipids serum_phospholipids 0.0358 0.793 no up no no no no 14:0/18:0-PC+blood 18:1/16:0-PI+blood 0 0.62254902 0.411282051 serum_phospholipids serum_phospholipids 0.00289 0.793 up up no no no no 15-HETE+blood 18:1/16:0-PI+blood -0.475771229 0 0 serum_ARA serum_phospholipids 0.819 0.793 no no no no no no 16:0-LPC+blood 18:1/16:0-PI+blood 0 0 0.578119658 serum_phospholipids serum_phospholipids 0.00456 0.793 up up no no no no 16:0/16:0-PI+blood 18:1/16:0-PI+blood 0.712781955 0.732843137 0.595213675 serum_phospholipids serum_phospholipids 0.358 0.793 no no no no no no 16:0/16:1-PC+blood 18:1/16:0-PI+blood 0 0.62745098 0 serum_phospholipids serum_phospholipids 0.00283 0.793 up up no no no no 16:0/16:1-PI+blood 18:1/16:0-PI+blood 0.508270677 0.762254902 0.634188034 serum_phospholipids serum_phospholipids 0.262 0.793 no no no no no no 16:0/18:1-PE+blood 18:1/16:0-PI+blood 0.57443609 0.590686275 0 serum_phospholipids serum_phospholipids 0.000107 0.793 up up no no no no 16:0/18:2-PI+blood 18:1/16:0-PI+blood 0.568421053 0.617647059 0.660854701 serum_phospholipids serum_phospholipids 0.269 0.793 no no no no no no 16:0/20:3-PC+blood 18:1/16:0-PI+blood -0.57593985 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.793 no up up no no no 16:0/20:4-PC+blood 18:1/16:0-PI+blood 0 -0.764705882 0 serum_phospholipids serum_phospholipids 0.0262 0.793 no up no no no no 16:0/20:4-PE+blood 18:1/16:0-PI+blood 0.454135338 0 0 serum_phospholipids serum_phospholipids 0.00139 0.793 up up no no no no 16:0/20:4-PI+blood 18:1/16:0-PI+blood 0.678195489 0.625 0.545982906 serum_phospholipids serum_phospholipids 0.558 0.793 no no no no no no 16:0/22:6-PC+blood 18:1/16:0-PI+blood 0 -0.710784314 0 serum_phospholipids serum_phospholipids 4.53E-05 0.793 no up up no no no 16:1-LPC+blood 18:1/16:0-PI+blood 0 0 0.628717949 serum_phospholipids serum_phospholipids 0.0241 0.793 no up no no no no 16:1/16:0-PC+blood 18:1/16:0-PI+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.0215 0.793 no up up no no no 16:1/18:1-PG+blood 18:1/16:0-PI+blood 0 0.693627451 0 serum_phospholipids serum_phospholipids 3.21E-05 0.793 no up up no no no 16:1/18:2-PG+blood 18:1/16:0-PI+blood -0.466165414 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.793 no up up no no no 18:0-LPA+blood 18:1/16:0-PI+blood 0 0 0.524786325 serum_phospholipids serum_phospholipids 0.0725 0.793 no dn no no no no 18:0-LPC+blood 18:1/16:0-PI+blood 0.562406015 0 0 serum_phospholipids serum_phospholipids 0.554 0.793 no no no no no no 18:0-LPE+blood 18:1/16:0-PI+blood 0.542857143 0 0 serum_phospholipids serum_phospholipids 0.491 0.793 no no no no no no 18:0/18:0-PE+blood 18:1/16:0-PI+blood 0.596992481 0.678921569 0 serum_phospholipids serum_phospholipids 0.00896 0.793 up up no no no no 18:0/18:1-PE+blood 18:1/16:0-PI+blood 0.642105263 0.654411765 0 serum_phospholipids serum_phospholipids 0.00716 0.793 up up no no no no 18:0/18:1-PG+blood 18:1/16:0-PI+blood 0.518796992 0 0 serum_phospholipids serum_phospholipids 0.000842 0.793 no up no no no no 18:0/18:1-PI+blood 18:1/16:0-PI+blood 0.730827068 0.845588235 0.764786325 serum_phospholipids serum_phospholipids 0.599 0.793 no no no no no no 18:0/18:2-PC+blood 18:1/16:0-PI+blood -0.497744361 0 0 serum_phospholipids serum_phospholipids 1.74E-06 0.793 no up up no no no 18:0/18:2-PI+blood 18:1/16:0-PI+blood 0 0 0.664273504 serum_phospholipids serum_phospholipids 0.179 0.793 no no no no no no 18:0/20:3-PI+blood 18:1/16:0-PI+blood 0 0.536764706 0 serum_phospholipids serum_phospholipids 0.377 0.793 no no no no no no 18:0/20:4-PC+blood 18:1/16:0-PI+blood 0 -0.727941176 0 serum_phospholipids serum_phospholipids 0.454 0.793 no no no no no no 18:0/20:5-PC+blood 18:1/16:0-PI+blood -0.62406015 -0.75245098 -0.499487179 serum_phospholipids serum_phospholipids 0.17 0.793 no no no no no no 18:0/22:6-PI+blood 18:1/16:0-PI+blood 0 0 0.552820513 serum_phospholipids serum_phospholipids 0.425 0.793 no no no no no no 18:1/16:0-PE+blood 18:1/16:0-PI+blood 0.554887218 0.676470588 0 serum_phospholipids serum_phospholipids 0.000182 0.793 up up no no no no 11-HETE+blood 18:1/16:1-PE+blood 0 0.694028256 0 serum_ARA serum_phospholipids 0.464 0.000184 no no no up up no 12-ketoDCA+blood 18:1/16:1-PE+blood 0 -0.536788624 0 serum_bileacids serum_phospholipids 0.517 0.000184 no no no up up no "12,13-EPOME+blood" 18:1/16:1-PE+blood 0 0.51233345 0 serum_ARA serum_phospholipids 0.901 0.000184 no no no up up no 13-HODE+blood 18:1/16:1-PE+blood -0.448120301 0 0 serum_ARA serum_phospholipids 0.32 0.000184 no no no up up no 14:0/18:0-PC+blood 18:1/16:1-PE+blood 0 0.762254902 0.42974359 serum_phospholipids serum_phospholipids 0.00289 0.000184 up up no up up no 14:0/20:4-PC+blood 18:1/16:1-PE+blood 0 -0.517156863 0 serum_phospholipids serum_phospholipids 0.486 0.000184 no no no up up no 15-HETE+blood 18:1/16:1-PE+blood -0.516681494 0 0 serum_ARA serum_phospholipids 0.819 0.000184 no no no up up no 16:0-LPE+blood 18:1/16:1-PE+blood 0.696240602 0 0.561709402 serum_phospholipids serum_phospholipids 0.0711 0.000184 up up no up up no 16:0/16:0-PI+blood 18:1/16:1-PE+blood 0.726315789 0.578431373 0 serum_phospholipids serum_phospholipids 0.358 0.000184 no no no up up no 16:0/16:1-PC+blood 18:1/16:1-PE+blood 0 0.762254902 0.44 serum_phospholipids serum_phospholipids 0.00283 0.000184 up up no up up no 16:0/16:1-PI+blood 18:1/16:1-PE+blood 0.560902256 0.605392157 0.511111111 serum_phospholipids serum_phospholipids 0.262 0.000184 no no no up up no 16:0/18:0-PC+blood 18:1/16:1-PE+blood 0 0 -0.51042735 serum_phospholipids serum_phospholipids 0.521 0.000184 no no no up up no 16:0/18:0-PS+blood 18:1/16:1-PE+blood 0.630075188 0 0.422222222 serum_phospholipids serum_phospholipids 0.377 0.000184 no no no up up no 16:0/18:1-PC+blood 18:1/16:1-PE+blood -0.523308271 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.000184 up up up up up no 16:0/18:1-PE+blood 18:1/16:1-PE+blood 0.954887218 0.990196078 0.95965812 serum_phospholipids serum_phospholipids 0.000107 0.000184 up up no up up no 16:0/18:2-PC+blood 18:1/16:1-PE+blood -0.589473684 0 0 serum_phospholipids serum_phospholipids 3.24E-06 0.000184 no up up up up no 16:0/18:2-PI+blood 18:1/16:1-PE+blood 0.569924812 0.791666667 0 serum_phospholipids serum_phospholipids 0.269 0.000184 no no no up up no 16:0/20:3-PC+blood 18:1/16:1-PE+blood -0.673684211 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.000184 no up up up up no 16:0/20:4-PC+blood 18:1/16:1-PE+blood -0.637593985 -0.588235294 0 serum_phospholipids serum_phospholipids 0.0262 0.000184 no up no up up no 16:0/20:4-PE+blood 18:1/16:1-PE+blood 0.812030075 0.81372549 0.904273504 serum_phospholipids serum_phospholipids 0.00139 0.000184 up up no up up no 16:0/20:4-PI+blood 18:1/16:1-PE+blood 0.445112782 0 0.491965812 serum_phospholipids serum_phospholipids 0.558 0.000184 no no no up up no 16:0/22:6-PC+blood 18:1/16:1-PE+blood 0 -0.529411765 0 serum_phospholipids serum_phospholipids 4.53E-05 0.000184 no up up up up no 16:0/22:6-PE+blood 18:1/16:1-PE+blood 0.708270677 0.507352941 0.866666667 serum_phospholipids serum_phospholipids 0.000934 0.000184 up up no up up no 16:1/18:1-PG+blood 18:1/16:1-PE+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 3.21E-05 0.000184 no up up up up no 16:1/18:2-PG+blood 18:1/16:1-PE+blood -0.460150376 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.000184 no up up up up no 16:1+blood 18:1/16:1-PE+blood 0 0 0.571965812 yes serum_fattyacid serum_phospholipids 0.0186 0.000184 no no dn up up no 18:0-LPE+blood 18:1/16:1-PE+blood 0.62556391 0 0 serum_phospholipids serum_phospholipids 0.491 0.000184 no no no up up no 18:0/16:0-PC+blood 18:1/16:1-PE+blood -0.482706767 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.000184 up up up up up no 18:0/18:0-PE+blood 18:1/16:1-PE+blood 0.714285714 0.522058824 0 serum_phospholipids serum_phospholipids 0.00896 0.000184 up up no up up no 18:0/18:0-PS+blood 18:1/16:1-PE+blood 0.458646617 0 0.477606838 serum_phospholipids serum_phospholipids 0.00617 0.000184 no up no up up no 18:0/18:1-PE+blood 18:1/16:1-PE+blood 0.751879699 0.632352941 0 serum_phospholipids serum_phospholipids 0.00716 0.000184 up up no up up no 18:0/18:1-PG+blood 18:1/16:1-PE+blood 0.630075188 0 0 serum_phospholipids serum_phospholipids 0.000842 0.000184 no up no up up no 18:0/18:1-PI+blood 18:1/16:1-PE+blood 0 0.504901961 0 serum_phospholipids serum_phospholipids 0.599 0.000184 no no no up up no 18:0/18:2-PC+blood 18:1/16:1-PE+blood -0.55037594 0 0 serum_phospholipids serum_phospholipids 1.74E-06 0.000184 no up up up up no 18:0/20:2-PC+blood 18:1/16:1-PE+blood 0 0 -0.541196581 serum_phospholipids serum_phospholipids 0.733 0.000184 no no no up up no 18:0/20:3-PI+blood 18:1/16:1-PE+blood 0 0.595588235 0 serum_phospholipids serum_phospholipids 0.377 0.000184 no no no up up no 18:0/20:4-PC+blood 18:1/16:1-PE+blood -0.663157895 -0.666666667 0 serum_phospholipids serum_phospholipids 0.454 0.000184 no no no up up no 18:0/20:5-PC+blood 18:1/16:1-PE+blood -0.551879699 -0.691176471 0 serum_phospholipids serum_phospholipids 0.17 0.000184 no no no up up no 18:0/22:6-PE+blood 18:1/16:1-PE+blood 0.652631579 0 0.690940171 serum_phospholipids serum_phospholipids 0.00022 0.000184 up up no up up no 18:1-LPC+blood 18:1/16:1-PE+blood 0 -0.568627451 0 serum_phospholipids serum_phospholipids 0.179 0.000184 no no no up up no 18:1/16:0-PC+blood 18:1/16:1-PE+blood -0.589473684 0 0 serum_phospholipids serum_phospholipids 2.43E-05 0.000184 no up up up up no 18:1/16:0-PE+blood 18:1/16:1-PE+blood 0.869172932 0.911764706 0.76 serum_phospholipids serum_phospholipids 0.000182 0.000184 up up no up up no 18:1/16:0-PI+blood 18:1/16:1-PE+blood 0.554887218 0.593137255 0 serum_phospholipids serum_phospholipids 0.793 0.000184 no no no up up no 14:1/18:2-PG+blood 18:1/18:0-PC+blood 0 0 -0.407179487 serum_phospholipids serum_phospholipids 0.00259 1.83E-06 no up up no up up 16:0-LPE+blood 18:1/18:0-PC+blood -0.527819549 0 0 serum_phospholipids serum_phospholipids 0.0711 1.83E-06 up up no no up up 16:0/14:0-PC+blood 18:1/18:0-PC+blood 0.607518797 0.848039216 0.822905983 serum_phospholipids serum_phospholipids 0.0206 1.83E-06 no up up no up up 16:0/16:0-PC+blood 18:1/18:0-PC+blood 0.693233083 0.585784314 0.660854701 serum_phospholipids serum_phospholipids 0.00079 1.83E-06 no up up no up up 16:0/16:0-PI+blood 18:1/18:0-PC+blood -0.595488722 0 0 serum_phospholipids serum_phospholipids 0.358 1.83E-06 no no no no up up 16:0/16:1-PI+blood 18:1/18:0-PC+blood -0.633082707 0 0 serum_phospholipids serum_phospholipids 0.262 1.83E-06 no no no no up up 16:0/18:0-PC+blood 18:1/18:0-PC+blood 0.446616541 0 0.541880342 serum_phospholipids serum_phospholipids 0.521 1.83E-06 no no no no up up 16:0/18:0-PS+blood 18:1/18:0-PC+blood 0 0 -0.50017094 serum_phospholipids serum_phospholipids 0.377 1.83E-06 no no no no up up 16:0/18:1-PC+blood 18:1/18:0-PC+blood 0.780451128 0.830882353 0.579487179 serum_phospholipids serum_phospholipids 6.15E-07 1.83E-06 up up up no up up 16:0/18:1-PE+blood 18:1/18:0-PC+blood -0.630075188 0 0 serum_phospholipids serum_phospholipids 0.000107 1.83E-06 up up no no up up 16:0/18:2-PC+blood 18:1/18:0-PC+blood 0.885714286 0.799019608 0.833162393 serum_phospholipids serum_phospholipids 3.24E-06 1.83E-06 no up up no up up 16:0/18:2-PI+blood 18:1/18:0-PC+blood -0.445112782 0 0 serum_phospholipids serum_phospholipids 0.269 1.83E-06 no no no no up up 16:0/20:3-PC+blood 18:1/18:0-PC+blood 0.793984962 0.68627451 0.477606838 serum_phospholipids serum_phospholipids 5.43E-06 1.83E-06 no up up no up up 16:0/20:4-PC+blood 18:1/18:0-PC+blood 0.536842105 0 0.571282051 serum_phospholipids serum_phospholipids 0.0262 1.83E-06 no up no no up up 16:0/20:4-PI+blood 18:1/18:0-PC+blood -0.580451128 -0.504901961 0 serum_phospholipids serum_phospholipids 0.558 1.83E-06 no no no no up up 16:0/22:0-PE+blood 18:1/18:0-PC+blood 0 0 0.463931624 serum_phospholipids serum_phospholipids 0.00839 1.83E-06 dn no up no up up 16:0/22:6-PC+blood 18:1/18:0-PC+blood 0.633082707 0 0.745641026 serum_phospholipids serum_phospholipids 4.53E-05 1.83E-06 no up up no up up 16:1-LPC+blood 18:1/18:0-PC+blood 0 -0.529411765 0 serum_phospholipids serum_phospholipids 0.0241 1.83E-06 no up no no up up 16:1/16:0-PC+blood 18:1/18:0-PC+blood 0.751879699 0 0.71008547 serum_phospholipids serum_phospholipids 0.0215 1.83E-06 no up up no up up 16:1/16:1-PC+blood 18:1/18:0-PC+blood 0.62406015 0 0.543931624 serum_phospholipids serum_phospholipids 0.0177 1.83E-06 no no up no up up 16:1/18:2-PG+blood 18:1/18:0-PC+blood 0.62556391 0 0 serum_phospholipids serum_phospholipids 1.40E-08 1.83E-06 no up up no up up 18:0-LPC+blood 18:1/18:0-PC+blood 0 -0.536764706 0 serum_phospholipids serum_phospholipids 0.554 1.83E-06 no no no no up up 18:0-LPE+blood 18:1/18:0-PC+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.491 1.83E-06 no no no no up up 18:0/16:0-PC+blood 18:1/18:0-PC+blood 0.732330827 0.779411765 0.553504274 serum_phospholipids serum_phospholipids 9.64E-07 1.83E-06 up up up no up up 18:0/18:0-PE+blood 18:1/18:0-PC+blood -0.57443609 0 0 serum_phospholipids serum_phospholipids 0.00896 1.83E-06 up up no no up up 18:0/18:0-PS+blood 18:1/18:0-PC+blood 0 0 -0.476239316 serum_phospholipids serum_phospholipids 0.00617 1.83E-06 no up no no up up 18:0/18:1-PE+blood 18:1/18:0-PC+blood -0.581954887 0 -0.448205128 serum_phospholipids serum_phospholipids 0.00716 1.83E-06 up up no no up up 18:0/18:1-PG+blood 18:1/18:0-PC+blood 0 0 -0.595213675 serum_phospholipids serum_phospholipids 0.000842 1.83E-06 no up no no up up 18:0/18:2-PC+blood 18:1/18:0-PC+blood 0.980451128 0.99754902 0.993846154 serum_phospholipids serum_phospholipids 1.74E-06 1.83E-06 no up up no up up 18:0/20:4-PC+blood 18:1/18:0-PC+blood 0.523308271 0 0.532991453 serum_phospholipids serum_phospholipids 0.454 1.83E-06 no no no no up up 18:0/20:5-PC+blood 18:1/18:0-PC+blood 0.57443609 0 0.572649573 serum_phospholipids serum_phospholipids 0.17 1.83E-06 no no no no up up 18:0/22:6-PC+blood 18:1/18:0-PC+blood 0.457142857 0 0.517948718 serum_phospholipids serum_phospholipids 0.0775 1.83E-06 no no up no up up 18:0+blood 18:1/18:0-PC+blood 0 0 0.488547009 serum_fattyacid serum_phospholipids 0.344 1.83E-06 no no no no up up 18:1/16:0-PC+blood 18:1/18:0-PC+blood 0.876691729 0.794117647 0.827008547 serum_phospholipids serum_phospholipids 2.43E-05 1.83E-06 no up up no up up 18:1/16:0-PE+blood 18:1/18:0-PC+blood -0.643609023 0 -0.410598291 serum_phospholipids serum_phospholipids 0.000182 1.83E-06 up up no no up up 18:1/16:0-PI+blood 18:1/18:0-PC+blood -0.529323308 0 0 serum_phospholipids serum_phospholipids 0.793 1.83E-06 no no no no up up 18:1/16:1-PE+blood 18:1/18:0-PC+blood -0.578947368 0 0 serum_phospholipids serum_phospholipids 0.000184 1.83E-06 up up no no up up 3-(3-Hydroxyphenyl)propanoic acid+stool 18:1/18:0-PC+blood 0 0 -0.529323308 stool_cometabolism serum_phospholipids 0.33 1.83E-06 no no no no up up Adherens junction 18:1/18:0-PC+blood 0 0 -0.409230769 kegg serum_phospholipids NA 1.83E-06 no no no no up up Alzheimer disease 18:1/18:0-PC+blood 0 0 -0.504615385 kegg serum_phospholipids NA 1.83E-06 no no no no up up Amyotrophic lateral sclerosis 18:1/18:0-PC+blood 0 0 -0.510769231 kegg serum_phospholipids NA 1.83E-06 no no no no up up Arrhythmogenic right ventricular cardiomyopathy 18:1/18:0-PC+blood 0 0 -0.410769231 kegg serum_phospholipids NA 1.83E-06 no up up no up up Butyricicoccus 18:1/18:0-PC+blood 0 0 -0.421448237 butyrate-producing Genus serum_phospholipids 0.852 1.83E-06 no no no no up up Cardiac muscle contraction 18:1/18:0-PC+blood 0 0 -0.561538462 kegg serum_phospholipids NA 1.83E-06 no no up no up up Central carbon metabolism in cancer 18:1/18:0-PC+blood 0 -0.555882353 0 kegg serum_phospholipids NA 1.83E-06 no no no no up up DCA+stool 18:1/18:0-PC+blood 0 0 -0.514285714 stool_bileacids serum_phospholipids 0.195 1.83E-06 no no no no up up Diabetic cardiomyopathy 18:1/18:0-PC+blood 0 0 -0.515384615 kegg serum_phospholipids NA 1.83E-06 no no no no up up Dilated cardiomyopathy 18:1/18:0-PC+blood 0 0 -0.414615385 kegg serum_phospholipids NA 1.83E-06 no up up no up up Focal adhesion 18:1/18:0-PC+blood 0 0 -0.43 kegg serum_phospholipids NA 1.83E-06 no up up no up up Fusobacterium 18:1/18:0-PC+blood 0 -0.647778583 0 Genus serum_phospholipids 0.628 1.83E-06 no no no no up up Gap junction 18:1/18:0-PC+blood 0.48245614 0 0 kegg serum_phospholipids NA 1.83E-06 no no no no up up GCDCA+stool 18:1/18:0-PC+blood 0 0.609090909 0 yes stool_bileacids serum_phospholipids 0.0471 1.83E-06 no dn no no up up Glutamatergic synapse 18:1/18:0-PC+blood 0.464912281 0 0 kegg serum_phospholipids NA 1.83E-06 no up up no up up Hippo signaling pathway 18:1/18:0-PC+blood 0 0 -0.449230769 kegg serum_phospholipids NA 1.83E-06 no no no no up up Huntington disease 18:1/18:0-PC+blood 0 0 -0.463846154 kegg serum_phospholipids NA 1.83E-06 no no no no up up Intestinal immune network for IgA production 18:1/18:0-PC+blood 0.492982456 0 0 kegg serum_phospholipids NA 1.83E-06 no no no no up up L-Tyrosine+stool 18:1/18:0-PC+blood 0 0 0.45112782 stool_cometabolism serum_phospholipids 0.44 1.83E-06 no no no no up up Lachnospira 18:1/18:0-PC+blood 0 0 0.44178147 butyrate-producing Genus serum_phospholipids 0.279 1.83E-06 no no no no up up mTOR signaling pathway 18:1/18:0-PC+blood 0 0 0.483846154 kegg serum_phospholipids NA 1.83E-06 no no no no up up Non-alcoholic fatty liver disease 18:1/18:0-PC+blood 0 0 -0.456153846 kegg serum_phospholipids NA 1.83E-06 no no no no up up Oxidative phosphorylation 18:1/18:0-PC+blood 0 0 -0.481538462 kegg serum_phospholipids NA 1.83E-06 no no no no up up Phenylacetic acid+stool 18:1/18:0-PC+blood 0 -0.763636364 0 stool_cometabolism serum_phospholipids 0.785 1.83E-06 no no no no up up Prion disease 18:1/18:0-PC+blood 0 0 -0.553846154 kegg serum_phospholipids NA 1.83E-06 no no no no up up Propionic acid+stool 18:1/18:0-PC+blood 0 0 -0.502255639 yes stool_scfa serum_phospholipids 0.0436 1.83E-06 dn no up no up up Retrograde endocannabinoid signaling 18:1/18:0-PC+blood 0 0 -0.405384615 kegg serum_phospholipids NA 1.83E-06 no no up no up up Salivary secretion 18:1/18:0-PC+blood 0.573684211 0 0 kegg serum_phospholipids NA 1.83E-06 no no no no up up TCA+stool 18:1/18:0-PC+blood -0.566713053 0 0 stool_bileacids serum_phospholipids 0.458 1.83E-06 no no no no up up Thyroid hormone signaling pathway 18:1/18:0-PC+blood 0 0 -0.526923077 kegg serum_phospholipids NA 1.83E-06 no no no no up up total_stool_scfa+stool 18:1/18:0-PC+blood 0 0 -0.467669173 stool_scfa serum_phospholipids 0.0534 1.83E-06 dn no up no up up 11-HETE+blood 18:1/18:0-PE+blood 0 0.501879937 0 serum_ARA serum_phospholipids 0.464 1.39E-06 no no no up up no 12-ketoDCA+blood 18:1/18:0-PE+blood 0 -0.559840896 0 serum_bileacids serum_phospholipids 0.517 1.39E-06 no no no up up no "12,13-EPOME+blood" 18:1/18:0-PE+blood 0 0.541144378 0 serum_ARA serum_phospholipids 0.901 1.39E-06 no no no up up no 13-HODE+blood 18:1/18:0-PE+blood -0.481203008 0 0 serum_ARA serum_phospholipids 0.32 1.39E-06 no no no up up no 14:0-LPC+blood 18:1/18:0-PE+blood 0 0.49754902 0 serum_phospholipids serum_phospholipids 0.00689 1.39E-06 up up no up up no 14:0/18:0-PC+blood 18:1/18:0-PE+blood 0 0.629901961 0 serum_phospholipids serum_phospholipids 0.00289 1.39E-06 up up no up up no 14:0+blood 18:1/18:0-PE+blood 0 0.490196078 0 yes serum_fattyacid serum_phospholipids 0.00572 1.39E-06 up no dn up up no 14:1/18:2-PG+blood 18:1/18:0-PE+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 0.00259 1.39E-06 no up up up up no 16:0-LPE+blood 18:1/18:0-PE+blood 0.621052632 0 0 serum_phospholipids serum_phospholipids 0.0711 1.39E-06 up up no up up no 16:0/14:0-PC+blood 18:1/18:0-PE+blood 0 0 -0.451623932 serum_phospholipids serum_phospholipids 0.0206 1.39E-06 no up up up up no 16:0/16:0-PI+blood 18:1/18:0-PE+blood 0.52481203 0.573529412 0 serum_phospholipids serum_phospholipids 0.358 1.39E-06 no no no up up no 16:0/16:1-PC+blood 18:1/18:0-PE+blood 0 0.639705882 0 serum_phospholipids serum_phospholipids 0.00283 1.39E-06 up up no up up no 16:0/18:0-PS+blood 18:1/18:0-PE+blood 0.69924812 0 0.414017094 serum_phospholipids serum_phospholipids 0.377 1.39E-06 no no no up up no 16:0/18:1-PE+blood 18:1/18:0-PE+blood 0.837593985 0.865196078 0.876923077 serum_phospholipids serum_phospholipids 0.000107 1.39E-06 up up no up up no 16:0/18:2-PC+blood 18:1/18:0-PE+blood -0.452631579 0 0 serum_phospholipids serum_phospholipids 3.24E-06 1.39E-06 no up up up up no 16:0/18:2-PI+blood 18:1/18:0-PE+blood 0 0.81372549 0 serum_phospholipids serum_phospholipids 0.269 1.39E-06 no no no up up no 16:0/20:3-PC+blood 18:1/18:0-PE+blood -0.50075188 0 0 serum_phospholipids serum_phospholipids 5.43E-06 1.39E-06 no up up up up no 16:0/20:4-PC+blood 18:1/18:0-PE+blood -0.544360902 -0.68872549 0 serum_phospholipids serum_phospholipids 0.0262 1.39E-06 no up no up up no 16:0/20:4-PE+blood 18:1/18:0-PE+blood 0.798496241 0.651960784 0.757264957 serum_phospholipids serum_phospholipids 0.00139 1.39E-06 up up no up up no 16:0/22:6-PC+blood 18:1/18:0-PE+blood 0 -0.620098039 0 serum_phospholipids serum_phospholipids 4.53E-05 1.39E-06 no up up up up no 16:0/22:6-PE+blood 18:1/18:0-PE+blood 0.827067669 0 0.823589744 serum_phospholipids serum_phospholipids 0.000934 1.39E-06 up up no up up no 16:1+blood 18:1/18:0-PE+blood 0 0 0.467350427 yes serum_fattyacid serum_phospholipids 0.0186 1.39E-06 no no dn up up no 18:0-LPA+blood 18:1/18:0-PE+blood 0.529323308 0 0 serum_phospholipids serum_phospholipids 0.0725 1.39E-06 no dn no up up no 18:0-LPE+blood 18:1/18:0-PE+blood 0.780451128 0 0.419487179 serum_phospholipids serum_phospholipids 0.491 1.39E-06 no no no up up no 18:0/18:0-PE+blood 18:1/18:0-PE+blood 0.696240602 0.75245098 0.599316239 serum_phospholipids serum_phospholipids 0.00896 1.39E-06 up up no up up no 18:0/18:0-PS+blood 18:1/18:0-PE+blood 0.476691729 0 0.450940171 serum_phospholipids serum_phospholipids 0.00617 1.39E-06 no up no up up no 18:0/18:1-PE+blood 18:1/18:0-PE+blood 0.747368421 0.821078431 0.685470085 serum_phospholipids serum_phospholipids 0.00716 1.39E-06 up up no up up no 18:0/18:1-PG+blood 18:1/18:0-PE+blood 0.630075188 0 0.451623932 serum_phospholipids serum_phospholipids 0.000842 1.39E-06 no up no up up no 18:0/18:1-PI+blood 18:1/18:0-PE+blood 0 0.492647059 0 serum_phospholipids serum_phospholipids 0.599 1.39E-06 no no no up up no 18:0/20:4-PC+blood 18:1/18:0-PE+blood -0.520300752 -0.772058824 0 serum_phospholipids serum_phospholipids 0.454 1.39E-06 no no no up up no 18:0/20:5-PC+blood 18:1/18:0-PE+blood 0 -0.759803922 0 serum_phospholipids serum_phospholipids 0.17 1.39E-06 no no no up up no 18:0/22:6-PE+blood 18:1/18:0-PE+blood 0.723308271 0 0.68957265 serum_phospholipids serum_phospholipids 0.00022 1.39E-06 up up no up up no 18:1/16:0-PC+blood 18:1/18:0-PE+blood -0.466165414 0 0 serum_phospholipids serum_phospholipids 2.43E-05 1.39E-06 no up up up up no 18:1/16:0-PE+blood 18:1/18:0-PE+blood 0.745864662 0.860294118 0.870769231 serum_phospholipids serum_phospholipids 0.000182 1.39E-06 up up no up up no 18:1/16:0-PI+blood 18:1/18:0-PE+blood 0 0.590686275 0 serum_phospholipids serum_phospholipids 0.793 1.39E-06 no no no up up no 18:1/16:1-PE+blood 18:1/18:0-PE+blood 0.842105263 0.852941176 0.844786325 serum_phospholipids serum_phospholipids 0.000184 1.39E-06 up up no up up no 12-HEPE+blood 18:1/18:0-PI+blood 0 0.523615897 0 serum_ARA serum_phospholipids 0.312 0.0931 no no no no no up 14:0-LPC+blood 18:1/18:0-PI+blood 0 0 0.424957265 serum_phospholipids serum_phospholipids 0.00689 0.0931 up up no no no up 14:1/18:2-PG+blood 18:1/18:0-PI+blood 0 0 0.408547009 serum_phospholipids serum_phospholipids 0.00259 0.0931 no up up no no up 15-HETE+blood 18:1/18:0-PI+blood -0.477286424 0 0 serum_ARA serum_phospholipids 0.819 0.0931 no no no no no up 16:0-LPC+blood 18:1/18:0-PI+blood 0 0 0.61025641 serum_phospholipids serum_phospholipids 0.00456 0.0931 up up no no no up 16:0/18:2-PI+blood 18:1/18:0-PI+blood 0 0 0.504957265 serum_phospholipids serum_phospholipids 0.269 0.0931 no no no no no up 16:0/20:5-PC+blood 18:1/18:0-PI+blood -0.511278195 0 0 serum_phospholipids serum_phospholipids 0.628 0.0931 no no no no no up 16:1/16:0-PC+blood 18:1/18:0-PI+blood 0 0 -0.457777778 serum_phospholipids serum_phospholipids 0.0215 0.0931 no up up no no up 16:1/16:1-PC+blood 18:1/18:0-PI+blood 0 0 -0.435897436 serum_phospholipids serum_phospholipids 0.0177 0.0931 no no up no no up 18:0-LPA+blood 18:1/18:0-PI+blood 0 0 0.496752137 serum_phospholipids serum_phospholipids 0.0725 0.0931 no dn no no no up 18:0-LPC+blood 18:1/18:0-PI+blood 0 0 0.481025641 serum_phospholipids serum_phospholipids 0.554 0.0931 no no no no no up 18:0/18:1-PI+blood 18:1/18:0-PI+blood 0.607518797 0.541666667 0.651282051 serum_phospholipids serum_phospholipids 0.599 0.0931 no no no no no up 18:0/18:2-PI+blood 18:1/18:0-PI+blood 0.612030075 0.617647059 0.843418803 serum_phospholipids serum_phospholipids 0.179 0.0931 no no no no no up 18:0/20:4-PI+blood 18:1/18:0-PI+blood 0.514285714 0 0 serum_phospholipids serum_phospholipids 0.167 0.0931 no no no no no up 18:0/20:5-PC+blood 18:1/18:0-PI+blood 0 -0.558823529 0 serum_phospholipids serum_phospholipids 0.17 0.0931 no no no no no up 18:1-LPE+blood 18:1/18:0-PI+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.117 0.0931 no no no no no up 18:1/16:0-PI+blood 18:1/18:0-PI+blood 0 0.509803922 0.747692308 serum_phospholipids serum_phospholipids 0.793 0.0931 no no no no no up 14:0-LPC+blood 18:1/18:0-PS+blood -0.494736842 0 0 serum_phospholipids serum_phospholipids 0.00689 0.193 up up no no no no 16:0/16:1-PI+blood 18:1/18:0-PS+blood -0.458646617 0 0 serum_phospholipids serum_phospholipids 0.262 0.193 no no no no no no 16:0/18:0-PS+blood 18:1/18:0-PS+blood 0.470676692 0.816176471 0.787350427 serum_phospholipids serum_phospholipids 0.377 0.193 no no no no no no 16:0/18:1-PC+blood 18:1/18:0-PS+blood 0.526315789 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.193 up up up no no no 16:0/18:2-PI+blood 18:1/18:0-PS+blood -0.496240602 0 0 serum_phospholipids serum_phospholipids 0.269 0.193 no no no no no no 16:0/20:5-PG+blood 18:1/18:0-PS+blood 0.569924812 0 0.564444444 serum_phospholipids serum_phospholipids 0.00656 0.193 no up no no no no 16:0/22:6-PE+blood 18:1/18:0-PS+blood 0 0.602941176 0 serum_phospholipids serum_phospholipids 0.000934 0.193 up up no no no no 16:0+blood 18:1/18:0-PS+blood 0 0.504901961 0 yes serum_fattyacid serum_phospholipids 0.00876 0.193 up no no no no no 16:1/16:0-PC+blood 18:1/18:0-PS+blood 0.484210526 0 0 serum_phospholipids serum_phospholipids 0.0215 0.193 no up up no no no 16:1/16:1-PC+blood 18:1/18:0-PS+blood 0.726315789 0 0 serum_phospholipids serum_phospholipids 0.0177 0.193 no no up no no no 16:1/18:1-PG+blood 18:1/18:0-PS+blood 0.718796992 0 0.504273504 serum_phospholipids serum_phospholipids 3.21E-05 0.193 no up up no no no 16:1/18:2-PG+blood 18:1/18:0-PS+blood 0.690225564 0 0.505641026 serum_phospholipids serum_phospholipids 1.40E-08 0.193 no up up no no no 18:0/16:0-PC+blood 18:1/18:0-PS+blood 0.539849624 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.193 up up up no no no 18:0/18:0-PS+blood 18:1/18:0-PS+blood 0.586466165 0.742647059 0.754529915 serum_phospholipids serum_phospholipids 0.00617 0.193 no up no no no no 18:0/18:2-PC+blood 18:1/18:0-PS+blood 0.448120301 0 0 serum_phospholipids serum_phospholipids 1.74E-06 0.193 no up up no no no 18:0/20:4-PI+blood 18:1/18:0-PS+blood 0 0.723039216 0.537777778 serum_phospholipids serum_phospholipids 0.167 0.193 no no no no no no 18:0/22:6-PA+blood 18:1/18:0-PS+blood 0.730827068 0.656862745 0.693675214 serum_phospholipids serum_phospholipids 0.22 0.193 no no no no no no 18:0/22:6-PE+blood 18:1/18:0-PS+blood 0 0.612745098 0 serum_phospholipids serum_phospholipids 0.00022 0.193 up up no no no no 18:0/22:6-PI+blood 18:1/18:0-PS+blood 0 0.593137255 0 serum_phospholipids serum_phospholipids 0.425 0.193 no no no no no no 18:0+blood 18:1/18:0-PS+blood 0 0.784313725 0 serum_fattyacid serum_phospholipids 0.344 0.193 no no no no no no 18:1/16:0-PI+blood 18:1/18:0-PS+blood -0.464661654 0 0 serum_phospholipids serum_phospholipids 0.793 0.193 no no no no no no 18:1/18:0-PC+blood 18:1/18:0-PS+blood 0.478195489 0 0 serum_phospholipids serum_phospholipids 1.83E-06 0.193 no up up no no no 11-HETE+blood 18:1/18:1-PC+blood 0 0.564973415 0 serum_ARA serum_phospholipids 0.464 1.34E-05 no no no no up up "12,13-EPOME+blood" 18:1/18:1-PC+blood 0 0 -0.428480668 serum_ARA serum_phospholipids 0.901 1.34E-05 no no no no up up 14:0/16:0-PC+blood 18:1/18:1-PC+blood 0 0.607843137 0 serum_phospholipids serum_phospholipids 0.0358 1.34E-05 no up no no up up 14:0/18:0-PC+blood 18:1/18:1-PC+blood 0 0.669117647 0.44957265 serum_phospholipids serum_phospholipids 0.00289 1.34E-05 up up no no up up 16:0-LPC+blood 18:1/18:1-PC+blood 0 -0.485294118 0 serum_phospholipids serum_phospholipids 0.00456 1.34E-05 up up no no up up 16:0-LPE+blood 18:1/18:1-PC+blood -0.819548872 0 0 serum_phospholipids serum_phospholipids 0.0711 1.34E-05 up up no no up up 16:0/14:0-PC+blood 18:1/18:1-PC+blood 0.484210526 0.602941176 0 serum_phospholipids serum_phospholipids 0.0206 1.34E-05 no up up no up up 16:0/16:0-PI+blood 18:1/18:1-PC+blood -0.633082707 0 0 serum_phospholipids serum_phospholipids 0.358 1.34E-05 no no no no up up 16:0/16:1-PC+blood 18:1/18:1-PC+blood 0 0.674019608 0.441367521 serum_phospholipids serum_phospholipids 0.00283 1.34E-05 up up no no up up 16:0/16:1-PI+blood 18:1/18:1-PC+blood -0.470676692 0 0 serum_phospholipids serum_phospholipids 0.262 1.34E-05 no no no no up up 16:0/18:0-PS+blood 18:1/18:1-PC+blood -0.50075188 0 0 serum_phospholipids serum_phospholipids 0.377 1.34E-05 no no no no up up 16:0/18:1-PC+blood 18:1/18:1-PC+blood 0.493233083 0 0.607521368 serum_phospholipids serum_phospholipids 6.15E-07 1.34E-05 up up up no up up 16:0/18:1-PE+blood 18:1/18:1-PC+blood -0.589473684 0 0 serum_phospholipids serum_phospholipids 0.000107 1.34E-05 up up no no up up 16:0/18:2-PC+blood 18:1/18:1-PC+blood 0.615037594 0 0.438632479 serum_phospholipids serum_phospholipids 3.24E-06 1.34E-05 no up up no up up 16:0/20:3-PC+blood 18:1/18:1-PC+blood 0.926315789 0.946078431 0.98017094 serum_phospholipids serum_phospholipids 5.43E-06 1.34E-05 no up up no up up 16:0/20:4-PC+blood 18:1/18:1-PC+blood 0.512781955 0 0 serum_phospholipids serum_phospholipids 0.0262 1.34E-05 no up no no up up 16:0/20:4-PE+blood 18:1/18:1-PC+blood -0.652631579 0 0 serum_phospholipids serum_phospholipids 0.00139 1.34E-05 up up no no up up 16:0/20:4-PI+blood 18:1/18:1-PC+blood -0.502255639 0 0 serum_phospholipids serum_phospholipids 0.558 1.34E-05 no no no no up up 16:0/20:5-PC+blood 18:1/18:1-PC+blood 0 0 -0.593162393 serum_phospholipids serum_phospholipids 0.628 1.34E-05 no no no no up up 16:0/22:6-PE+blood 18:1/18:1-PC+blood -0.589473684 0 0 serum_phospholipids serum_phospholipids 0.000934 1.34E-05 up up no no up up 16:1/18:1-PG+blood 18:1/18:1-PC+blood 0 0.56127451 0 serum_phospholipids serum_phospholipids 3.21E-05 1.34E-05 no up up no up up 16:1/18:2-PG+blood 18:1/18:1-PC+blood 0.514285714 0 0 serum_phospholipids serum_phospholipids 1.40E-08 1.34E-05 no up up no up up 18:0-LPE+blood 18:1/18:1-PC+blood -0.572932331 0 0 serum_phospholipids serum_phospholipids 0.491 1.34E-05 no no no no up up 18:0/16:0-PC+blood 18:1/18:1-PC+blood 0 0 0.58017094 serum_phospholipids serum_phospholipids 9.64E-07 1.34E-05 up up up no up up 18:0/18:0-PC+blood 18:1/18:1-PC+blood 0 0.519607843 0 serum_phospholipids serum_phospholipids 0.426 1.34E-05 no no no no up up 18:0/18:0-PE+blood 18:1/18:1-PC+blood -0.583458647 0 0 serum_phospholipids serum_phospholipids 0.00896 1.34E-05 up up no no up up 18:0/18:1-PC+blood 18:1/18:1-PC+blood 0 0.509803922 0 serum_phospholipids serum_phospholipids 0.393 1.34E-05 no no no no up up 18:0/18:1-PE+blood 18:1/18:1-PC+blood -0.604511278 0 0 serum_phospholipids serum_phospholipids 0.00716 1.34E-05 up up no no up up 18:0/18:1-PG+blood 18:1/18:1-PC+blood -0.448120301 0 0 serum_phospholipids serum_phospholipids 0.000842 1.34E-05 no up no no up up 18:0/18:1-PI+blood 18:1/18:1-PC+blood 0 0.539215686 0 serum_phospholipids serum_phospholipids 0.599 1.34E-05 no no no no up up 18:0/18:2-PC+blood 18:1/18:1-PC+blood 0.621052632 0.568627451 0.461880342 serum_phospholipids serum_phospholipids 1.74E-06 1.34E-05 no up up no up up 18:0/20:3-PC+blood 18:1/18:1-PC+blood 0 0.647058824 0.725811966 serum_phospholipids serum_phospholipids 0.0682 1.34E-05 no up no no up up 18:0/20:3-PI+blood 18:1/18:1-PC+blood 0 0.779411765 0 serum_phospholipids serum_phospholipids 0.377 1.34E-05 no no no no up up 18:0/20:4-PC+blood 18:1/18:1-PC+blood 0.463157895 0 0 serum_phospholipids serum_phospholipids 0.454 1.34E-05 no no no no up up 18:0/22:6-PE+blood 18:1/18:1-PC+blood -0.586466165 0 0 serum_phospholipids serum_phospholipids 0.00022 1.34E-05 up up no no up up 18:0/22:6-PI+blood 18:1/18:1-PC+blood -0.478195489 0 0 serum_phospholipids serum_phospholipids 0.425 1.34E-05 no no no no up up 18:1/16:0-PC+blood 18:1/18:1-PC+blood 0.571428571 0 0.424273504 serum_phospholipids serum_phospholipids 2.43E-05 1.34E-05 no up up no up up 18:1/16:0-PE+blood 18:1/18:1-PC+blood -0.64962406 0 0 serum_phospholipids serum_phospholipids 0.000182 1.34E-05 up up no no up up 18:1/16:0-PI+blood 18:1/18:1-PC+blood -0.476691729 0 0 serum_phospholipids serum_phospholipids 0.793 1.34E-05 no no no no up up 18:1/16:1-PE+blood 18:1/18:1-PC+blood -0.667669173 0 0 serum_phospholipids serum_phospholipids 0.000184 1.34E-05 up up no no up up 18:1/18:0-PC+blood 18:1/18:1-PC+blood 0.67518797 0.573529412 0.450940171 serum_phospholipids serum_phospholipids 1.83E-06 1.34E-05 no up up no up up 18:1/18:0-PE+blood 18:1/18:1-PC+blood -0.568421053 0 0 serum_phospholipids serum_phospholipids 1.39E-06 1.34E-05 up up no no up up Adrenergic signaling in cardiomyocytes 18:1/18:1-PC+blood 0.496491228 0 0 kegg serum_phospholipids NA 1.34E-05 no no up no up up Antigen processing and presentation 18:1/18:1-PC+blood 0 0.667647059 0 kegg serum_phospholipids NA 1.34E-05 no no no no up up Butyricimonas 18:1/18:1-PC+blood 0.544842127 0 0 butyrate-producing Genus serum_phospholipids 0.17 1.34E-05 no no no no up up Calcium signaling pathway 18:1/18:1-PC+blood 0.578947368 0 0 kegg serum_phospholipids NA 1.34E-05 no up up no up up CDCA+stool 18:1/18:1-PC+blood 0 0.627272727 0 stool_bileacids serum_phospholipids 0.663 1.34E-05 no no no no up up Cholinergic synapse 18:1/18:1-PC+blood 0 -0.517647059 0 kegg serum_phospholipids NA 1.34E-05 no no no no up up DCA+stool 18:1/18:1-PC+blood 0 0 -0.452631579 stool_bileacids serum_phospholipids 0.195 1.34E-05 no no no no up up Epstein-Barr virus infection 18:1/18:1-PC+blood 0 0.744117647 0 kegg serum_phospholipids NA 1.34E-05 no no no no up up Ferroptosis 18:1/18:1-PC+blood 0 0 0.529230769 kegg serum_phospholipids NA 1.34E-05 no no no no up up Focal adhesion 18:1/18:1-PC+blood 0 0 -0.442307692 kegg serum_phospholipids NA 1.34E-05 no up up no up up FoxO signaling pathway 18:1/18:1-PC+blood 0 0 -0.475384615 kegg serum_phospholipids NA 1.34E-05 no no no no up up Fusobacterium 18:1/18:1-PC+blood 0 0 0.432714341 Genus serum_phospholipids 0.628 1.34E-05 no no no no up up Gastric cancer 18:1/18:1-PC+blood 0 0 -0.42 kegg serum_phospholipids NA 1.34E-05 no no no no up up GCDCA+stool 18:1/18:1-PC+blood 0 0.654545455 0 yes stool_bileacids serum_phospholipids 0.0471 1.34E-05 no dn no no up up HDCA+stool 18:1/18:1-PC+blood 0 0 -0.52481203 stool_bileacids serum_phospholipids 0.176 1.34E-05 no no no no up up Hepatocellular carcinoma 18:1/18:1-PC+blood 0 0 -0.433846154 kegg serum_phospholipids NA 1.34E-05 no no no no up up Herpes simplex virus 1 infection 18:1/18:1-PC+blood 0 0.647058824 0 kegg serum_phospholipids NA 1.34E-05 no no no no up up Hippo signaling pathway 18:1/18:1-PC+blood 0 0 -0.443846154 kegg serum_phospholipids NA 1.34E-05 no no no no up up Human cytomegalovirus infection 18:1/18:1-PC+blood 0 0.670588235 0 kegg serum_phospholipids NA 1.34E-05 no no dn no up up Human immunodeficiency virus 1 infection 18:1/18:1-PC+blood 0 0.7 0 kegg serum_phospholipids NA 1.34E-05 no no no no up up Human T-cell leukemia virus 1 infection 18:1/18:1-PC+blood 0 0.679411765 0 kegg serum_phospholipids NA 1.34E-05 no no no no up up Intestinal immune network for IgA production 18:1/18:1-PC+blood 0.666666667 0 0 kegg serum_phospholipids NA 1.34E-05 no no no no up up Kaposi sarcoma-associated herpesvirus infection 18:1/18:1-PC+blood 0.531578947 0 0.48 kegg serum_phospholipids NA 1.34E-05 no no dn no up up Lachnospira 18:1/18:1-PC+blood 0 0 0.462329445 butyrate-producing Genus serum_phospholipids 0.279 1.34E-05 no no no no up up Malaria 18:1/18:1-PC+blood 0 0 0.46 kegg serum_phospholipids NA 1.34E-05 no no no no up up MAPK signaling pathway 18:1/18:1-PC+blood 0 -0.644117647 0 kegg serum_phospholipids NA 1.34E-05 no no no no up up Mineral absorption 18:1/18:1-PC+blood 0 0 0.466923077 kegg serum_phospholipids NA 1.34E-05 no no no no up up Mitophagy - animal 18:1/18:1-PC+blood 0 0 0.418461538 kegg serum_phospholipids NA 1.34E-05 no no no no up up Necroptosis 18:1/18:1-PC+blood 0 0 0.445384615 kegg serum_phospholipids NA 1.34E-05 no no no no up up Olfactory transduction 18:1/18:1-PC+blood -0.59122807 0 0 kegg serum_phospholipids NA 1.34E-05 no no no no up up Pancreatic secretion 18:1/18:1-PC+blood 0.485964912 0 0 kegg serum_phospholipids NA 1.34E-05 no no no no up up Peroxisome 18:1/18:1-PC+blood -0.480701754 0 0 kegg serum_phospholipids NA 1.34E-05 no no no no up up Phenylacetic acid+stool 18:1/18:1-PC+blood 0 -0.736363636 0 stool_cometabolism serum_phospholipids 0.785 1.34E-05 no no no no up up Phosphatidylinositol signaling system 18:1/18:1-PC+blood 0 0 -0.429230769 kegg serum_phospholipids NA 1.34E-05 no no no no up up Platinum drug resistance 18:1/18:1-PC+blood 0 0 -0.403846154 kegg serum_phospholipids NA 1.34E-05 no no no no up up Prevotella 18:1/18:1-PC+blood -0.477784795 0 0 acetate-producing Genus serum_phospholipids 0.287 1.34E-05 no no no no up up Progesterone-mediated oocyte maturation 18:1/18:1-PC+blood 0 -0.55 0 kegg serum_phospholipids NA 1.34E-05 no no no no up up Ruminococcus 18:1/18:1-PC+blood 0.47518797 0 0 acetate-producing Genus serum_phospholipids 0.335 1.34E-05 no no no no up up Sphingolipid signaling pathway 18:1/18:1-PC+blood 0 0 -0.406153846 kegg serum_phospholipids NA 1.34E-05 no no no no up up TCA+stool 18:1/18:1-PC+blood -0.59697443 0.718181818 0.527819549 stool_bileacids serum_phospholipids 0.458 1.34E-05 no no no no up up Th1 and Th2 cell differentiation 18:1/18:1-PC+blood 0.547368421 0 0 kegg serum_phospholipids NA 1.34E-05 no no no no up up Th17 cell differentiation 18:1/18:1-PC+blood 0.547368421 0 0 kegg serum_phospholipids NA 1.34E-05 no no no no up up Thyroid hormone signaling pathway 18:1/18:1-PC+blood 0 0 -0.484615385 kegg serum_phospholipids NA 1.34E-05 no no no no up up Ubiquitin mediated proteolysis 18:1/18:1-PC+blood 0 0 0.417692308 kegg serum_phospholipids NA 1.34E-05 no no no no up up 11-HETE+blood 18:1/18:1-PE+blood 0 0.570709186 0 serum_ARA serum_phospholipids 0.464 1.03E-05 no no no up up no 12-ketoDCA+blood 18:1/18:1-PE+blood 0 -0.625704531 0 serum_bileacids serum_phospholipids 0.517 1.03E-05 no no no up up no 12-ketoDCA+stool 18:1/18:1-PE+blood 0 0 0.658646617 stool_bileacids serum_phospholipids 0.505 1.03E-05 no no no up up no "12,13-EPOME+blood" 18:1/18:1-PE+blood 0 0.587492391 0 serum_ARA serum_phospholipids 0.901 1.03E-05 no no no up up no 14:0/18:0-PC+blood 18:1/18:1-PE+blood 0 0.605392157 0 serum_phospholipids serum_phospholipids 0.00289 1.03E-05 up up no up up no 14:0+blood 18:1/18:1-PE+blood 0 0.492647059 0 yes serum_fattyacid serum_phospholipids 0.00572 1.03E-05 up no dn up up no 16:0-LPE+blood 18:1/18:1-PE+blood 0.518796992 0 0 serum_phospholipids serum_phospholipids 0.0711 1.03E-05 up up no up up no 16:0/14:0-PC+blood 18:1/18:1-PE+blood 0 0 -0.491965812 serum_phospholipids serum_phospholipids 0.0206 1.03E-05 no up up up up no 16:0/16:0-PI+blood 18:1/18:1-PE+blood 0.520300752 0 0 serum_phospholipids serum_phospholipids 0.358 1.03E-05 no no no up up no 16:0/16:1-PC+blood 18:1/18:1-PE+blood 0 0.637254902 0 serum_phospholipids serum_phospholipids 0.00283 1.03E-05 up up no up up no 16:0/18:0-PS+blood 18:1/18:1-PE+blood 0.727819549 0 0.431794872 serum_phospholipids serum_phospholipids 0.377 1.03E-05 no no no up up no 16:0/18:1-PE+blood 18:1/18:1-PE+blood 0.869172932 0.835784314 0.826324786 serum_phospholipids serum_phospholipids 0.000107 1.03E-05 up up no up up no 16:0/18:2-PC+blood 18:1/18:1-PE+blood -0.473684211 0 0 serum_phospholipids serum_phospholipids 3.24E-06 1.03E-05 no up up up up no 16:0/18:2-PI+blood 18:1/18:1-PE+blood 0 0.774509804 0 serum_phospholipids serum_phospholipids 0.269 1.03E-05 no no no up up no 16:0/20:3-PC+blood 18:1/18:1-PE+blood -0.458646617 0 0 serum_phospholipids serum_phospholipids 5.43E-06 1.03E-05 no up up up up no 16:0/20:4-PC+blood 18:1/18:1-PE+blood -0.518796992 -0.612745098 0 serum_phospholipids serum_phospholipids 0.0262 1.03E-05 no up no up up no 16:0/20:4-PE+blood 18:1/18:1-PE+blood 0.757894737 0.62254902 0.717606838 serum_phospholipids serum_phospholipids 0.00139 1.03E-05 up up no up up no 16:0/22:6-PE+blood 18:1/18:1-PE+blood 0.839097744 0 0.796239316 serum_phospholipids serum_phospholipids 0.000934 1.03E-05 up up no up up no 16:1+blood 18:1/18:1-PE+blood 0 0 0.470769231 yes serum_fattyacid serum_phospholipids 0.0186 1.03E-05 no no dn up up no 18:0-LPA+blood 18:1/18:1-PE+blood 0.503759398 0 0 serum_phospholipids serum_phospholipids 0.0725 1.03E-05 no dn no up up no 18:0-LPE+blood 18:1/18:1-PE+blood 0.703759398 0 0.426324786 serum_phospholipids serum_phospholipids 0.491 1.03E-05 no no no up up no 18:0/18:0-PE+blood 18:1/18:1-PE+blood 0.712781955 0.762254902 0.612307692 serum_phospholipids serum_phospholipids 0.00896 1.03E-05 up up no up up no 18:0/18:0-PS+blood 18:1/18:1-PE+blood 0.526315789 0 0.431111111 serum_phospholipids serum_phospholipids 0.00617 1.03E-05 no up no up up no 18:0/18:1-PE+blood 18:1/18:1-PE+blood 0.760902256 0.828431373 0.714871795 serum_phospholipids serum_phospholipids 0.00716 1.03E-05 up up no up up no 18:0/18:1-PG+blood 18:1/18:1-PE+blood 0.607518797 0 0.443418803 serum_phospholipids serum_phospholipids 0.000842 1.03E-05 no up no up up no 18:0/18:2-PI+blood 18:1/18:1-PE+blood 0.505263158 0 0 serum_phospholipids serum_phospholipids 0.179 1.03E-05 no no no up up no 18:0/20:4-PC+blood 18:1/18:1-PE+blood -0.493233083 -0.664215686 0 serum_phospholipids serum_phospholipids 0.454 1.03E-05 no no no up up no 18:0/20:5-PC+blood 18:1/18:1-PE+blood 0 -0.700980392 0 serum_phospholipids serum_phospholipids 0.17 1.03E-05 no no no up up no 18:0/22:6-PE+blood 18:1/18:1-PE+blood 0.694736842 0 0.633504274 serum_phospholipids serum_phospholipids 0.00022 1.03E-05 up up no up up no 18:1-LPC+blood 18:1/18:1-PE+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.179 1.03E-05 no no no up up no 18:1/16:0-PC+blood 18:1/18:1-PE+blood -0.49924812 0 0 serum_phospholipids serum_phospholipids 2.43E-05 1.03E-05 no up up up up no 18:1/16:0-PE+blood 18:1/18:1-PE+blood 0.792481203 0.828431373 0.848205128 serum_phospholipids serum_phospholipids 0.000182 1.03E-05 up up no up up no 18:1/16:0-PI+blood 18:1/18:1-PE+blood 0 0.512254902 0 serum_phospholipids serum_phospholipids 0.793 1.03E-05 no no no up up no 18:1/16:1-PE+blood 18:1/18:1-PE+blood 0.873684211 0.833333333 0.795555556 serum_phospholipids serum_phospholipids 0.000184 1.03E-05 up up no up up no 18:1/18:0-PE+blood 18:1/18:1-PE+blood 0.960902256 0.968137255 0.976068376 serum_phospholipids serum_phospholipids 1.39E-06 1.03E-05 up up no up up no 18:1/18:1-PC+blood 18:1/18:1-PE+blood -0.506766917 0 0 serum_phospholipids serum_phospholipids 1.34E-05 1.03E-05 no up up up up no 18:1+blood 18:1/18:1-PE+blood 0 0 0.442735043 yes serum_fattyacid serum_phospholipids 0.00202 1.03E-05 up no dn up up no Antigen processing and presentation 18:1/18:1-PE+blood 0 0 0.550769231 kegg serum_phospholipids NA 1.03E-05 no no no up up no Cell adhesion molecules 18:1/18:1-PE+blood 0 0 0.429230769 kegg serum_phospholipids NA 1.03E-05 no no no up up no Clostridium 18:1/18:1-PE+blood 0 0.485077898 0 Genus serum_phospholipids 0.925 1.03E-05 no no no up up no DCA+stool 18:1/18:1-PE+blood 0 0 0.45112782 stool_bileacids serum_phospholipids 0.195 1.03E-05 no no no up up no Epstein-Barr virus infection 18:1/18:1-PE+blood 0 0 0.441538462 kegg serum_phospholipids NA 1.03E-05 no no no up up no Ferroptosis 18:1/18:1-PE+blood -0.584210526 0 0 kegg serum_phospholipids NA 1.03E-05 no no no up up no Herpes simplex virus 1 infection 18:1/18:1-PE+blood 0 0 0.452307692 kegg serum_phospholipids NA 1.03E-05 no no no up up no Human cytomegalovirus infection 18:1/18:1-PE+blood 0 0 0.510769231 kegg serum_phospholipids NA 1.03E-05 no no dn up up no Human immunodeficiency virus 1 infection 18:1/18:1-PE+blood 0 0 0.502307692 kegg serum_phospholipids NA 1.03E-05 no no no up up no Human T-cell leukemia virus 1 infection 18:1/18:1-PE+blood 0 0 0.543076923 kegg serum_phospholipids NA 1.03E-05 no no no up up no Intestinal immune network for IgA production 18:1/18:1-PE+blood -0.552631579 0 0 kegg serum_phospholipids NA 1.03E-05 no no no up up no Kaposi sarcoma-associated herpesvirus infection 18:1/18:1-PE+blood -0.496491228 0 0 kegg serum_phospholipids NA 1.03E-05 no no dn up up no L-Phenylalanine+stool 18:1/18:1-PE+blood 0.686813187 0 0 stool_cometabolism serum_phospholipids 0.398 1.03E-05 no no no up up no L-Tryptophan+stool 18:1/18:1-PE+blood 0.598901099 0 0 stool_cometabolism serum_phospholipids 0.557 1.03E-05 no no no up up no L-Tyrosine+stool 18:1/18:1-PE+blood 0.582417582 0 -0.50075188 stool_cometabolism serum_phospholipids 0.44 1.03E-05 no no no up up no LCA+stool 18:1/18:1-PE+blood 0 0 0.463157895 stool_bileacids serum_phospholipids 0.314 1.03E-05 no no no up up no Lipid and atherosclerosis 18:1/18:1-PE+blood 0 0 0.416923077 kegg serum_phospholipids NA 1.03E-05 no no no up up no Longevity regulating pathway - multiple species 18:1/18:1-PE+blood 0.477192982 0 0 kegg serum_phospholipids NA 1.03E-05 no no no up up no MAPK signaling pathway 18:1/18:1-PE+blood 0 -0.617647059 0 kegg serum_phospholipids NA 1.03E-05 no no no up up no Measles 18:1/18:1-PE+blood 0 -0.588235294 0 kegg serum_phospholipids NA 1.03E-05 no no no up up no Parabacteroides 18:1/18:1-PE+blood 0 -0.56127451 0 Genus serum_phospholipids 4.19E-05 1.03E-05 no up up up up no Pertussis 18:1/18:1-PE+blood 0 0 0.422307692 kegg serum_phospholipids NA 1.03E-05 no no dn up up no PPAR signaling pathway 18:1/18:1-PE+blood 0 0 0.469230769 kegg serum_phospholipids NA 1.03E-05 no no no up up no Primary immunodeficiency 18:1/18:1-PE+blood 0.489473684 0 0 kegg serum_phospholipids NA 1.03E-05 no no no up up no Ruminococcus 18:1/18:1-PE+blood 0 0.526057732 0 Genus serum_phospholipids 0.0679 1.03E-05 no no dn up up no Systemic lupus erythematosus 18:1/18:1-PE+blood 0 0 0.451538462 kegg serum_phospholipids NA 1.03E-05 no no no up up no TCA+stool 18:1/18:1-PE+blood 0 0.636363636 0 stool_bileacids serum_phospholipids 0.458 1.03E-05 no no no up up no 11-HETE+blood 18:1/18:1-PG+blood 0 0.636670549 0 serum_ARA serum_phospholipids 0.464 0.00352 no no no no up up 13-HODE+blood 18:1/18:1-PG+blood 0 0 -0.442735043 serum_ARA serum_phospholipids 0.32 0.00352 no no no no up up 14:0-LPC+blood 18:1/18:1-PG+blood -0.481203008 0 0 serum_phospholipids serum_phospholipids 0.00689 0.00352 up up no no up up 14:0/16:0-PC+blood 18:1/18:1-PG+blood 0 0.664215686 0 serum_phospholipids serum_phospholipids 0.0358 0.00352 no up no no up up 14:0/18:0-PC+blood 18:1/18:1-PG+blood 0 0.649509804 0 serum_phospholipids serum_phospholipids 0.00289 0.00352 up up no no up up 14:0+blood 18:1/18:1-PG+blood 0 0 -0.466666667 yes serum_fattyacid serum_phospholipids 0.00572 0.00352 up no dn no up up 16:0/16:1-PC+blood 18:1/18:1-PG+blood 0 0.705882353 0 serum_phospholipids serum_phospholipids 0.00283 0.00352 up up no no up up 16:0/16:1-PI+blood 18:1/18:1-PG+blood 0 0.735294118 0 serum_phospholipids serum_phospholipids 0.262 0.00352 no no no no up up 16:0/18:0-PS+blood 18:1/18:1-PG+blood 0 0 0.485811966 serum_phospholipids serum_phospholipids 0.377 0.00352 no no no no up up 16:0/18:1-PC+blood 18:1/18:1-PG+blood 0.533834586 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.00352 up up up no up up 16:0/18:2-PI+blood 18:1/18:1-PG+blood -0.482706767 0 0 serum_phospholipids serum_phospholipids 0.269 0.00352 no no no no up up 16:0/20:3-PC+blood 18:1/18:1-PG+blood 0 0.593137255 0 serum_phospholipids serum_phospholipids 5.43E-06 0.00352 no up up no up up 16:0/20:5-PG+blood 18:1/18:1-PG+blood 0.539849624 0 0.628034188 serum_phospholipids serum_phospholipids 0.00656 0.00352 no up no no up up 16:1/18:1-PG+blood 18:1/18:1-PG+blood 0.819548872 0.781862745 0.772307692 serum_phospholipids serum_phospholipids 3.21E-05 0.00352 no up up no up up 16:1/18:2-PG+blood 18:1/18:1-PG+blood 0.603007519 0.504901961 0.762735043 serum_phospholipids serum_phospholipids 1.40E-08 0.00352 no up up no up up 18:0/16:0-PC+blood 18:1/18:1-PG+blood 0.520300752 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.00352 up up up no up up 18:0/18:0-PC+blood 18:1/18:1-PG+blood 0.577443609 0.710784314 0 serum_phospholipids serum_phospholipids 0.426 0.00352 no no no no up up 18:0/18:0-PS+blood 18:1/18:1-PG+blood 0 0.534313725 0.494700855 serum_phospholipids serum_phospholipids 0.00617 0.00352 no up no no up up 18:0/18:1-PC+blood 18:1/18:1-PG+blood 0.6 0.740196078 0 serum_phospholipids serum_phospholipids 0.393 0.00352 no no no no up up 18:0/18:1-PG+blood 18:1/18:1-PG+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.000842 0.00352 no up no no up up 18:0/18:1-PI+blood 18:1/18:1-PG+blood 0 0.575980392 0 serum_phospholipids serum_phospholipids 0.599 0.00352 no no no no up up 18:0/18:2-PI+blood 18:1/18:1-PG+blood 0 0 0.407179487 serum_phospholipids serum_phospholipids 0.179 0.00352 no no no no up up 18:0/20:3-PC+blood 18:1/18:1-PG+blood 0 0.710784314 0 serum_phospholipids serum_phospholipids 0.0682 0.00352 no up no no up up 18:0/20:3-PI+blood 18:1/18:1-PG+blood 0 0.676470588 0 serum_phospholipids serum_phospholipids 0.377 0.00352 no no no no up up 18:0/20:5-PC+blood 18:1/18:1-PG+blood 0 -0.519607843 0 serum_phospholipids serum_phospholipids 0.17 0.00352 no no no no up up 18:0/22:6-PA+blood 18:1/18:1-PG+blood 0.621052632 0 0 serum_phospholipids serum_phospholipids 0.22 0.00352 no no no no up up 18:0+blood 18:1/18:1-PG+blood 0 0.595588235 0 serum_fattyacid serum_phospholipids 0.344 0.00352 no no no no up up 18:1/16:0-PI+blood 18:1/18:1-PG+blood 0 0.512254902 0 serum_phospholipids serum_phospholipids 0.793 0.00352 no no no no up up 18:1/18:0-PS+blood 18:1/18:1-PG+blood 0.645112782 0 0.465299145 serum_phospholipids serum_phospholipids 0.193 0.00352 no no no no up up 18:1/18:1-PC+blood 18:1/18:1-PG+blood 0 0.661764706 0 serum_phospholipids serum_phospholipids 1.34E-05 0.00352 no up up no up up 18:1/18:1-PE+blood 18:1/18:1-PG+blood 0 0.573529412 0 serum_phospholipids serum_phospholipids 1.03E-05 0.00352 up up no no up up 16:0/16:1-PI+blood 18:1/18:1-PI+blood 0 0.566176471 0 serum_phospholipids serum_phospholipids 0.262 0.111 no no no dn no no 16:0/18:3-PC+blood 18:1/18:1-PI+blood -0.457142857 -0.487745098 0 serum_phospholipids serum_phospholipids 0.00216 0.111 no up up dn no no 16:0/20:4-PC+blood 18:1/18:1-PI+blood 0 -0.522058824 0 serum_phospholipids serum_phospholipids 0.0262 0.111 no up no dn no no 16:0/20:5-PC+blood 18:1/18:1-PI+blood 0 0 -0.418119658 serum_phospholipids serum_phospholipids 0.628 0.111 no no no dn no no 16:0/22:6-PC+blood 18:1/18:1-PI+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 4.53E-05 0.111 no up up dn no no 16:1/16:1-PC+blood 18:1/18:1-PI+blood 0 0 -0.496752137 serum_phospholipids serum_phospholipids 0.0177 0.111 no no up dn no no 16:1/18:1-PG+blood 18:1/18:1-PI+blood 0 0.644607843 0 serum_phospholipids serum_phospholipids 3.21E-05 0.111 no up up dn no no 18:0-LPC+blood 18:1/18:1-PI+blood 0 0 0.401025641 serum_phospholipids serum_phospholipids 0.554 0.111 no no no dn no no 18:0/18:1-PI+blood 18:1/18:1-PI+blood 0.669172932 0.887254902 0.785982906 serum_phospholipids serum_phospholipids 0.599 0.111 no no no dn no no 18:0/18:2-PI+blood 18:1/18:1-PI+blood 0 0 0.427692308 serum_phospholipids serum_phospholipids 0.179 0.111 no no no dn no no 18:0/20:3-PI+blood 18:1/18:1-PI+blood 0 0.529411765 0 serum_phospholipids serum_phospholipids 0.377 0.111 no no no dn no no 18:1-LPC+blood 18:1/18:1-PI+blood 0.562406015 0 0 serum_phospholipids serum_phospholipids 0.179 0.111 no no no dn no no 18:1/16:0-PI+blood 18:1/18:1-PI+blood 0.466165414 0.794117647 0.525470085 serum_phospholipids serum_phospholipids 0.793 0.111 no no no dn no no 18:1/16:1-PE+blood 18:1/18:1-PI+blood 0 0 -0.403076923 serum_phospholipids serum_phospholipids 0.000184 0.111 up up no dn no no 18:1/18:0-PI+blood 18:1/18:1-PI+blood 0.532330827 0.495098039 0.525470085 serum_phospholipids serum_phospholipids 0.0931 0.111 no no up dn no no 13-HODE+blood 18:1/18:2-PE+blood -0.484210526 0 0 serum_ARA serum_phospholipids 0.32 0.000293 no no no up up no 14:0/18:0-PC+blood 18:1/18:2-PE+blood 0 0.522058824 0 serum_phospholipids serum_phospholipids 0.00289 0.000293 up up no up up no 16:0-LPE+blood 18:1/18:2-PE+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.0711 0.000293 up up no up up no 16:0/14:0-PC+blood 18:1/18:2-PE+blood 0 0 -0.52 serum_phospholipids serum_phospholipids 0.0206 0.000293 no up up up up no 16:0/16:0-PI+blood 18:1/18:2-PE+blood 0 0.487745098 0 serum_phospholipids serum_phospholipids 0.358 0.000293 no no no up up no 16:0/16:1-PC+blood 18:1/18:2-PE+blood 0 0.522058824 0 serum_phospholipids serum_phospholipids 0.00283 0.000293 up up no up up no 16:0/18:1-PC+blood 18:1/18:2-PE+blood -0.521804511 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.000293 up up up up up no 16:0/18:1-PE+blood 18:1/18:2-PE+blood 0.783458647 0.803921569 0.666324786 serum_phospholipids serum_phospholipids 0.000107 0.000293 up up no up up no 16:0/18:2-PC+blood 18:1/18:2-PE+blood -0.639097744 0 0 serum_phospholipids serum_phospholipids 3.24E-06 0.000293 no up up up up no 16:0/18:2-PI+blood 18:1/18:2-PE+blood 0 0.786764706 0 serum_phospholipids serum_phospholipids 0.269 0.000293 no no no up up no 16:0/20:4-PC+blood 18:1/18:2-PE+blood -0.532330827 -0.789215686 0 serum_phospholipids serum_phospholipids 0.0262 0.000293 no up no up up no 16:0/20:4-PE+blood 18:1/18:2-PE+blood 0.529323308 0.651960784 0.627350427 serum_phospholipids serum_phospholipids 0.00139 0.000293 up up no up up no 16:0/22:6-PC+blood 18:1/18:2-PE+blood -0.485714286 -0.681372549 0 serum_phospholipids serum_phospholipids 4.53E-05 0.000293 no up up up up no 16:0/22:6-PE+blood 18:1/18:2-PE+blood 0.65112782 0 0.665641026 serum_phospholipids serum_phospholipids 0.000934 0.000293 up up no up up no 16:1/16:0-PC+blood 18:1/18:2-PE+blood -0.541353383 0 0 serum_phospholipids serum_phospholipids 0.0215 0.000293 no up up up up no 18:0-LPE+blood 18:1/18:2-PE+blood 0.45112782 0 0.490598291 serum_phospholipids serum_phospholipids 0.491 0.000293 no no no up up no 18:0/16:0-PC+blood 18:1/18:2-PE+blood -0.518796992 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.000293 up up up up up no 18:0/18:0-PE+blood 18:1/18:2-PE+blood 0.672180451 0.767156863 0.610940171 serum_phospholipids serum_phospholipids 0.00896 0.000293 up up no up up no 18:0/18:1-PE+blood 18:1/18:2-PE+blood 0.682706767 0.776960784 0.715555556 serum_phospholipids serum_phospholipids 0.00716 0.000293 up up no up up no 18:0/18:1-PI+blood 18:1/18:2-PE+blood 0 0.556372549 0 serum_phospholipids serum_phospholipids 0.599 0.000293 no no no up up no 18:0/18:2-PC+blood 18:1/18:2-PE+blood 0 0 -0.40034188 serum_phospholipids serum_phospholipids 1.74E-06 0.000293 no up up up up no 18:0/18:2-PI+blood 18:1/18:2-PE+blood 0.44962406 0 0 serum_phospholipids serum_phospholipids 0.179 0.000293 no no no up up no 18:0/20:4-PC+blood 18:1/18:2-PE+blood -0.496240602 -0.799019608 0 serum_phospholipids serum_phospholipids 0.454 0.000293 no no no up up no 18:0/20:5-PC+blood 18:1/18:2-PE+blood 0 -0.786764706 0 serum_phospholipids serum_phospholipids 0.17 0.000293 no no no up up no 18:0/22:6-PA+blood 18:1/18:2-PE+blood 0 0 -0.404444444 serum_phospholipids serum_phospholipids 0.22 0.000293 no no no up up no 18:0/22:6-PE+blood 18:1/18:2-PE+blood 0 0 0.438632479 serum_phospholipids serum_phospholipids 0.00022 0.000293 up up no up up no 18:1-LPE+blood 18:1/18:2-PE+blood 0.557894737 0 0 serum_phospholipids serum_phospholipids 0.117 0.000293 no no no up up no 18:1/16:0-PC+blood 18:1/18:2-PE+blood -0.681203008 0 0 serum_phospholipids serum_phospholipids 2.43E-05 0.000293 no up up up up no 18:1/16:0-PE+blood 18:1/18:2-PE+blood 0.727819549 0.850490196 0.727179487 serum_phospholipids serum_phospholipids 0.000182 0.000293 up up no up up no 18:1/16:0-PI+blood 18:1/18:2-PE+blood 0 0.661764706 0 serum_phospholipids serum_phospholipids 0.793 0.000293 no no no up up no 18:1/16:1-PE+blood 18:1/18:2-PE+blood 0.678195489 0.791666667 0.627350427 serum_phospholipids serum_phospholipids 0.000184 0.000293 up up no up up no 18:1/18:0-PC+blood 18:1/18:2-PE+blood -0.473684211 0 -0.408547009 serum_phospholipids serum_phospholipids 1.83E-06 0.000293 no up up up up no 18:1/18:0-PE+blood 18:1/18:2-PE+blood 0.747368421 0.906862745 0.822905983 serum_phospholipids serum_phospholipids 1.39E-06 0.000293 up up no up up no 18:1/18:0-PI+blood 18:1/18:2-PE+blood 0 0.610294118 0 serum_phospholipids serum_phospholipids 0.0931 0.000293 no no up up up no 18:1/18:1-PE+blood 18:1/18:2-PE+blood 0.792481203 0.860294118 0.832478632 serum_phospholipids serum_phospholipids 1.03E-05 0.000293 up up no up up no 11-HETE+blood 18:1/18:2-PG+blood 0 0.513351479 0 serum_ARA serum_phospholipids 0.464 5.58E-07 no no no no up up 13-HODE+blood 18:1/18:2-PG+blood 0 0 -0.438632479 serum_ARA serum_phospholipids 0.32 5.58E-07 no no no no up up 14:0+blood 18:1/18:2-PG+blood 0 0 -0.439316239 yes serum_fattyacid serum_phospholipids 0.00572 5.58E-07 up no dn no up up 16:0-LPE+blood 18:1/18:2-PG+blood -0.57593985 0 0 serum_phospholipids serum_phospholipids 0.0711 5.58E-07 up up no no up up 16:0/14:0-PC+blood 18:1/18:2-PG+blood 0.512781955 0 0 serum_phospholipids serum_phospholipids 0.0206 5.58E-07 no up up no up up 16:0/16:0-PI+blood 18:1/18:2-PG+blood -0.487218045 0 0 serum_phospholipids serum_phospholipids 0.358 5.58E-07 no no no no up up 16:0/16:1-PC+blood 18:1/18:2-PG+blood 0 0.504901961 0 serum_phospholipids serum_phospholipids 0.00283 5.58E-07 up up no no up up 16:0/16:1-PI+blood 18:1/18:2-PG+blood -0.557894737 0.573529412 0 serum_phospholipids serum_phospholipids 0.262 5.58E-07 no no no no up up 16:0/18:0-PS+blood 18:1/18:2-PG+blood 0 0 0.427008547 serum_phospholipids serum_phospholipids 0.377 5.58E-07 no no no no up up 16:0/18:1-PC+blood 18:1/18:2-PG+blood 0.616541353 0 0 serum_phospholipids serum_phospholipids 6.15E-07 5.58E-07 up up up no up up 16:0/18:1-PE+blood 18:1/18:2-PG+blood -0.445112782 0 0 serum_phospholipids serum_phospholipids 0.000107 5.58E-07 up up no no up up 16:0/18:2-PC+blood 18:1/18:2-PG+blood 0.587969925 0 0 serum_phospholipids serum_phospholipids 3.24E-06 5.58E-07 no up up no up up 16:0/20:3-PC+blood 18:1/18:2-PG+blood 0.669172932 0 0 serum_phospholipids serum_phospholipids 5.43E-06 5.58E-07 no up up no up up 16:0/20:4-PI+blood 18:1/18:2-PG+blood -0.521804511 0 0 serum_phospholipids serum_phospholipids 0.558 5.58E-07 no no no no up up 16:0/20:5-PG+blood 18:1/18:2-PG+blood 0.514285714 0 0.716923077 serum_phospholipids serum_phospholipids 0.00656 5.58E-07 no up no no up up 16:1/16:0-PC+blood 18:1/18:2-PG+blood 0.533834586 0 0 serum_phospholipids serum_phospholipids 0.0215 5.58E-07 no up up no up up 16:1/16:1-PC+blood 18:1/18:2-PG+blood 0.57593985 0 0 serum_phospholipids serum_phospholipids 0.0177 5.58E-07 no no up no up up 16:1/18:1-PG+blood 18:1/18:2-PG+blood 0.760902256 0.74754902 0.624615385 serum_phospholipids serum_phospholipids 3.21E-05 5.58E-07 no up up no up up 16:1/18:2-PG+blood 18:1/18:2-PG+blood 0.968421053 0.816176471 0.901538462 serum_phospholipids serum_phospholipids 1.40E-08 5.58E-07 no up up no up up 18:0/16:0-PC+blood 18:1/18:2-PG+blood 0.560902256 0 0 serum_phospholipids serum_phospholipids 9.64E-07 5.58E-07 up up up no up up 18:0/18:0-PC+blood 18:1/18:2-PG+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 0.426 5.58E-07 no no no no up up 18:0/18:0-PE+blood 18:1/18:2-PG+blood -0.606015038 0 0 serum_phospholipids serum_phospholipids 0.00896 5.58E-07 up up no no up up 18:0/18:0-PS+blood 18:1/18:2-PG+blood 0 0 0.442051282 serum_phospholipids serum_phospholipids 0.00617 5.58E-07 no up no no up up 18:0/18:1-PC+blood 18:1/18:2-PG+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 0.393 5.58E-07 no no no no up up 18:0/18:1-PE+blood 18:1/18:2-PG+blood -0.630075188 0 0 serum_phospholipids serum_phospholipids 0.00716 5.58E-07 up up no no up up 18:0/18:1-PI+blood 18:1/18:2-PG+blood 0 0.605392157 0 serum_phospholipids serum_phospholipids 0.599 5.58E-07 no no no no up up 18:0/18:2-PC+blood 18:1/18:2-PG+blood 0.687218045 0 0 serum_phospholipids serum_phospholipids 1.74E-06 5.58E-07 no up up no up up 18:0/18:2-PI+blood 18:1/18:2-PG+blood 0 0.534313725 0.44 serum_phospholipids serum_phospholipids 0.179 5.58E-07 no no no no up up 18:0/20:3-PI+blood 18:1/18:2-PG+blood 0.460150376 0.583333333 0 serum_phospholipids serum_phospholipids 0.377 5.58E-07 no no no no up up 18:0/20:5-PC+blood 18:1/18:2-PG+blood 0 -0.536764706 0 serum_phospholipids serum_phospholipids 0.17 5.58E-07 no no no no up up 18:0/22:6-PA+blood 18:1/18:2-PG+blood 0.52481203 0 0.71965812 serum_phospholipids serum_phospholipids 0.22 5.58E-07 no no no no up up 18:0+blood 18:1/18:2-PG+blood 0 0.588235294 0 serum_fattyacid serum_phospholipids 0.344 5.58E-07 no no no no up up 18:1/16:0-PC+blood 18:1/18:2-PG+blood 0.593984962 0 0 serum_phospholipids serum_phospholipids 2.43E-05 5.58E-07 no up up no up up 18:1/16:0-PE+blood 18:1/18:2-PG+blood -0.554887218 0 0 serum_phospholipids serum_phospholipids 0.000182 5.58E-07 up up no no up up 18:1/16:0-PI+blood 18:1/18:2-PG+blood -0.479699248 0.558823529 0 serum_phospholipids serum_phospholipids 0.793 5.58E-07 no no no no up up 18:1/16:1-PE+blood 18:1/18:2-PG+blood -0.445112782 0 0 serum_phospholipids serum_phospholipids 0.000184 5.58E-07 up up no no up up 18:1/18:0-PC+blood 18:1/18:2-PG+blood 0.688721805 0 0 serum_phospholipids serum_phospholipids 1.83E-06 5.58E-07 no up up no up up 18:1/18:0-PS+blood 18:1/18:2-PG+blood 0.705263158 0.487745098 0.628034188 serum_phospholipids serum_phospholipids 0.193 5.58E-07 no no no no up up 18:1/18:1-PC+blood 18:1/18:2-PG+blood 0.541353383 0.519607843 0 serum_phospholipids serum_phospholipids 1.34E-05 5.58E-07 no up up no up up 18:1/18:1-PE+blood 18:1/18:2-PG+blood 0 0.492647059 0 serum_phospholipids serum_phospholipids 1.03E-05 5.58E-07 up up no no up up 18:1/18:1-PG+blood 18:1/18:2-PG+blood 0.655639098 0.855392157 0.747008547 serum_phospholipids serum_phospholipids 0.00352 5.58E-07 no up up no up up 18:1/18:1-PI+blood 18:1/18:2-PG+blood 0 0.49754902 0 serum_phospholipids serum_phospholipids 0.111 5.58E-07 dn no no no up up 18:1+blood 18:1/18:2-PG+blood 0 0 -0.542564103 yes serum_fattyacid serum_phospholipids 0.00202 5.58E-07 up no dn no up up Akkermansia 18:1/18:2-PG+blood 0 0 -0.485511029 acetate-producing Genus serum_phospholipids 0.23 5.58E-07 no no no no up up Biosynthesis of cofactors 18:1/18:2-PG+blood 0 -0.511764706 0 kegg serum_phospholipids NA 5.58E-07 no no no no up up Coprococcus 18:1/18:2-PG+blood -0.455639098 0 0 butyrate-producing Genus serum_phospholipids 0.612 5.58E-07 no no no no up up "Glycine, serine and threonine metabolism" 18:1/18:2-PG+blood 0 -0.5 0 kegg serum_phospholipids NA 5.58E-07 no up no no up up mRNA surveillance pathway 18:1/18:2-PG+blood 0 0 0.402307692 kegg serum_phospholipids NA 5.58E-07 no no no no up up NOD-like receptor signaling pathway 18:1/18:2-PG+blood 0 0 -0.410769231 kegg serum_phospholipids NA 5.58E-07 no no no no up up Parabacteroides 18:1/18:2-PG+blood 0.554887218 0 0 Genus serum_phospholipids 4.19E-05 5.58E-07 no up up no up up Pertussis 18:1/18:2-PG+blood 0 0 -0.407692308 kegg serum_phospholipids NA 5.58E-07 no no dn no up up Staphylococcus aureus infection 18:1/18:2-PG+blood 0 0 -0.409230769 kegg serum_phospholipids NA 5.58E-07 up no no no up up Toxoplasmosis 18:1/18:2-PG+blood 0 0 -0.409230769 kegg serum_phospholipids NA 5.58E-07 no no no no up up 16:0/16:0-PC+blood 18:1/18:2-PI+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.00079 0.0164 no up up dn no up 16:0/16:1-PC+blood 18:1/18:2-PI+blood -0.455639098 0 0 serum_phospholipids serum_phospholipids 0.00283 0.0164 up up no dn no up 16:0/18:0-PC+blood 18:1/18:2-PI+blood 0 0 0.414017094 serum_phospholipids serum_phospholipids 0.521 0.0164 no no no dn no up 16:0/18:0-PS+blood 18:1/18:2-PI+blood 0 0 -0.574700855 serum_phospholipids serum_phospholipids 0.377 0.0164 no no no dn no up 16:0/20:5-PC+blood 18:1/18:2-PI+blood -0.49924812 0 0 serum_phospholipids serum_phospholipids 0.628 0.0164 no no no dn no up 16:1/18:1-PG+blood 18:1/18:2-PI+blood 0 0 -0.577435897 serum_phospholipids serum_phospholipids 3.21E-05 0.0164 no up up dn no up 18:0-LPC+blood 18:1/18:2-PI+blood 0 0 0.466666667 serum_phospholipids serum_phospholipids 0.554 0.0164 no no no dn no up 18:0/18:0-PC+blood 18:1/18:2-PI+blood -0.454135338 0 0 serum_phospholipids serum_phospholipids 0.426 0.0164 no no no dn no up 18:0/18:0-PS+blood 18:1/18:2-PI+blood 0 0 -0.474871795 serum_phospholipids serum_phospholipids 0.00617 0.0164 no up no dn no up 18:0/18:1-PG+blood 18:1/18:2-PI+blood 0 0 -0.404444444 serum_phospholipids serum_phospholipids 0.000842 0.0164 no up no dn no up 18:0/18:2-PI+blood 18:1/18:2-PI+blood 0.562406015 0 0 serum_phospholipids serum_phospholipids 0.179 0.0164 no no no dn no up 18:1-LPC+blood 18:1/18:2-PI+blood 0 0.5 0 serum_phospholipids serum_phospholipids 0.179 0.0164 no no no dn no up 18:1-LPE+blood 18:1/18:2-PI+blood 0 0 0.451623932 serum_phospholipids serum_phospholipids 0.117 0.0164 no no no dn no up 18:1/18:0-PS+blood 18:1/18:2-PI+blood 0 0 -0.511794872 serum_phospholipids serum_phospholipids 0.193 0.0164 no no no dn no up 18:1/18:1-PG+blood 18:1/18:2-PI+blood 0 0 -0.403760684 serum_phospholipids serum_phospholipids 0.00352 0.0164 no up up dn no up 18:1/18:1-PI+blood 18:1/18:2-PI+blood 0 0.593137255 0 serum_phospholipids serum_phospholipids 0.111 0.0164 dn no no dn no up Slackia 18:1/18:2-PI+blood 0 0 0.44566099 Genus serum_phospholipids 0.94 0.0164 no no no dn no up "12,13-EPOME+blood" 18:1/20:3-PC+blood 0 0 -0.601746075 serum_ARA serum_phospholipids 0.901 0.00872 no no no no up up 16:0-LPE+blood 18:1/20:3-PC+blood -0.663157895 0 0 serum_phospholipids serum_phospholipids 0.0711 0.00872 up up no no up up 16:0/16:0-PI+blood 18:1/20:3-PC+blood -0.479699248 0 0 serum_phospholipids serum_phospholipids 0.358 0.00872 no no no no up up 16:0/20:3-PC+blood 18:1/20:3-PC+blood 0.796992481 0.718137255 0.827008547 serum_phospholipids serum_phospholipids 5.43E-06 0.00872 no up up no up up 16:0/20:4-PC+blood 18:1/20:3-PC+blood 0 0 0.494700855 serum_phospholipids serum_phospholipids 0.0262 0.00872 no up no no up up 16:0/20:4-PE+blood 18:1/20:3-PC+blood -0.536842105 0 0 serum_phospholipids serum_phospholipids 0.00139 0.00872 up up no no up up 16:0/20:5-PC+blood 18:1/20:3-PC+blood 0 -0.482843137 -0.504273504 serum_phospholipids serum_phospholipids 0.628 0.00872 no no no no up up 18:0-LPA+blood 18:1/20:3-PC+blood -0.472180451 0 0 serum_phospholipids serum_phospholipids 0.0725 0.00872 no dn no no up up 18:0/18:0-PS+blood 18:1/20:3-PC+blood 0 0 -0.421538462 serum_phospholipids serum_phospholipids 0.00617 0.00872 no up no no up up 18:0/18:1-PE+blood 18:1/20:3-PC+blood -0.485714286 0 0 serum_phospholipids serum_phospholipids 0.00716 0.00872 up up no no up up 18:0/18:2-PC+blood 18:1/20:3-PC+blood 0 0 0.416752137 serum_phospholipids serum_phospholipids 1.74E-06 0.00872 no up up no up up 18:0/20:2-PC+blood 18:1/20:3-PC+blood 0 0.593137255 0.40991453 serum_phospholipids serum_phospholipids 0.733 0.00872 no no no no up up 18:0/20:3-PC+blood 18:1/20:3-PC+blood 0 0.56372549 0.733333333 serum_phospholipids serum_phospholipids 0.0682 0.00872 no up no no up up 18:0/20:3-PI+blood 18:1/20:3-PC+blood 0 0.524509804 0 serum_phospholipids serum_phospholipids 0.377 0.00872 no no no no up up 18:0/20:4-PC+blood 18:1/20:3-PC+blood 0 0 0.501538462 serum_phospholipids serum_phospholipids 0.454 0.00872 no no no no up up 18:0/22:6-PE+blood 18:1/20:3-PC+blood -0.533834586 -0.549019608 0 serum_phospholipids serum_phospholipids 0.00022 0.00872 up up no no up up 18:1/16:0-PE+blood 18:1/20:3-PC+blood -0.488721805 0 0 serum_phospholipids serum_phospholipids 0.000182 0.00872 up up no no up up 18:1/16:0-PI+blood 18:1/20:3-PC+blood -0.551879699 0 0 serum_phospholipids serum_phospholipids 0.793 0.00872 no no no no up up 18:1/18:0-PC+blood 18:1/20:3-PC+blood 0 0 0.403760684 serum_phospholipids serum_phospholipids 1.83E-06 0.00872 no up up no up up 18:1/18:1-PC+blood 18:1/20:3-PC+blood 0.771428571 0.710784314 0.773675214 serum_phospholipids serum_phospholipids 1.34E-05 0.00872 no up up no up up 18:1/18:2-PG+blood 18:1/20:3-PC+blood 0.485714286 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.00872 no up up no up up Adipocytokine signaling pathway 18:1/20:3-PC+blood 0 0 0.456923077 kegg serum_phospholipids NA 0.00872 no no no no up up Alzheimer disease 18:1/20:3-PC+blood 0 0 -0.405384615 kegg serum_phospholipids NA 0.00872 no no no no up up AMPK signaling pathway 18:1/20:3-PC+blood 0 0 0.46 kegg serum_phospholipids NA 0.00872 no no no no up up Arachidonic acid metabolism 18:1/20:3-PC+blood 0 0 0.473846154 kegg serum_phospholipids NA 0.00872 no no no no up up Biosynthesis of amino acids 18:1/20:3-PC+blood 0 0 0.432307692 kegg serum_phospholipids NA 0.00872 no no no no up up Calcium signaling pathway 18:1/20:3-PC+blood 0.512280702 0 0 kegg serum_phospholipids NA 0.00872 no up up no up up Cardiac muscle contraction 18:1/20:3-PC+blood 0 0 -0.440769231 kegg serum_phospholipids NA 0.00872 no no up no up up Cell cycle 18:1/20:3-PC+blood 0 0 -0.447692308 kegg serum_phospholipids NA 0.00872 no no no no up up Cellular senescence 18:1/20:3-PC+blood 0.496491228 0 0 kegg serum_phospholipids NA 0.00872 no no no no up up Clostridium 18:1/20:3-PC+blood 0 0.555487535 0 Genus serum_phospholipids 0.925 0.00872 no no no no up up Colorectal cancer 18:1/20:3-PC+blood 0 0 -0.402307692 kegg serum_phospholipids NA 0.00872 no no no no up up Diabetic cardiomyopathy 18:1/20:3-PC+blood 0 0 -0.460769231 kegg serum_phospholipids NA 0.00872 no no no no up up Estrogen signaling pathway 18:1/20:3-PC+blood -0.461403509 0 0 kegg serum_phospholipids NA 0.00872 no no no no up up Ferroptosis 18:1/20:3-PC+blood 0 0 0.452307692 kegg serum_phospholipids NA 0.00872 no no no no up up Glioma 18:1/20:3-PC+blood 0 0 -0.420769231 kegg serum_phospholipids NA 0.00872 no no no no up up Glutathione metabolism 18:1/20:3-PC+blood 0 0 0.467692308 kegg serum_phospholipids NA 0.00872 no no no no up up "Glycine, serine and threonine metabolism" 18:1/20:3-PC+blood 0 0 0.404615385 kegg serum_phospholipids NA 0.00872 no up no no up up HDCA+stool 18:1/20:3-PC+blood 0 0 -0.532330827 stool_bileacids serum_phospholipids 0.176 0.00872 no no no no up up Inflammatory bowel disease 18:1/20:3-PC+blood 0.470175439 0 0 kegg serum_phospholipids NA 0.00872 no no no no up up Intestinal immune network for IgA production 18:1/20:3-PC+blood 0.624561404 0 0 kegg serum_phospholipids NA 0.00872 no no no no up up Kaposi sarcoma-associated herpesvirus infection 18:1/20:3-PC+blood 0 0.520588235 0.400769231 kegg serum_phospholipids NA 0.00872 no no dn no up up Lachnospira 18:1/20:3-PC+blood 0 0 0.551370671 butyrate-producing Genus serum_phospholipids 0.279 0.00872 no no no no up up Long-term potentiation 18:1/20:3-PC+blood 0 0 -0.512307692 kegg serum_phospholipids NA 0.00872 no no up no up up Longevity regulating pathway 18:1/20:3-PC+blood 0 0 0.433076923 kegg serum_phospholipids NA 0.00872 no no no no up up Malaria 18:1/20:3-PC+blood 0 0 0.424615385 kegg serum_phospholipids NA 0.00872 no no no no up up MAPK signaling pathway 18:1/20:3-PC+blood -0.505263158 0 0 kegg serum_phospholipids NA 0.00872 no no no no up up nutriCA+stool 18:1/20:3-PC+blood 0 0.623879467 0 stool_bileacids serum_phospholipids 0.481 0.00872 no no no no up up Oocyte meiosis 18:1/20:3-PC+blood 0 0 -0.569230769 kegg serum_phospholipids NA 0.00872 no no no no up up Oxidative phosphorylation 18:1/20:3-PC+blood 0 0 -0.424615385 kegg serum_phospholipids NA 0.00872 no no no no up up Peroxisome 18:1/20:3-PC+blood 0 0 0.437692308 kegg serum_phospholipids NA 0.00872 no no no no up up Phosphatidylinositol signaling system 18:1/20:3-PC+blood 0 0 -0.523076923 kegg serum_phospholipids NA 0.00872 no no no no up up Porphyrin and chlorophyll metabolism 18:1/20:3-PC+blood 0 0 0.462307692 kegg serum_phospholipids NA 0.00872 no no no no up up Prevotella 18:1/20:3-PC+blood -0.588108105 0 0 acetate-producing Genus serum_phospholipids 0.287 0.00872 no no no no up up Prion disease 18:1/20:3-PC+blood 0 0 -0.456153846 kegg serum_phospholipids NA 0.00872 no no no no up up Purine metabolism 18:1/20:3-PC+blood 0 0 0.434615385 kegg serum_phospholipids NA 0.00872 no no no no up up Ras signaling pathway 18:1/20:3-PC+blood 0 0 -0.503076923 yes kegg serum_phospholipids NA 0.00872 no up up no up up Retrograde endocannabinoid signaling 18:1/20:3-PC+blood 0 0 -0.556923077 kegg serum_phospholipids NA 0.00872 no no up no up up RNA degradation 18:1/20:3-PC+blood 0 0 -0.464615385 kegg serum_phospholipids NA 0.00872 no no no no up up Th1 and Th2 cell differentiation 18:1/20:3-PC+blood 0.461403509 0 0 kegg serum_phospholipids NA 0.00872 no no no no up up Thermogenesis 18:1/20:3-PC+blood 0 0 -0.404615385 kegg serum_phospholipids NA 0.00872 no no no no up up Viral protein interaction with cytokine and cytokine receptor 18:1/20:3-PC+blood 0.459649123 0 0 kegg serum_phospholipids NA 0.00872 no no no no up up Wnt signaling pathway 18:1/20:3-PC+blood 0 0 -0.551538462 kegg serum_phospholipids NA 0.00872 no no no no up up 11-HETE+blood 18:1/20:4-PC+blood 0 -0.599388039 0 serum_ARA serum_phospholipids 0.464 0.582 no no no no no no 14:0-LPC+blood 18:1/20:4-PC+blood -0.593984962 0 0 serum_phospholipids serum_phospholipids 0.00689 0.582 up up no no no no 14:0/18:0-PC+blood 18:1/20:4-PC+blood 0 -0.75 0 serum_phospholipids serum_phospholipids 0.00289 0.582 up up no no no no 16:0-LPC+blood 18:1/20:4-PC+blood 0 0 -0.658119658 serum_phospholipids serum_phospholipids 0.00456 0.582 up up no no no no 16:0/16:0-PI+blood 18:1/20:4-PC+blood -0.506766917 -0.713235294 0 serum_phospholipids serum_phospholipids 0.358 0.582 no no no no no no 16:0/16:1-PC+blood 18:1/20:4-PC+blood 0 -0.732843137 0 serum_phospholipids serum_phospholipids 0.00283 0.582 up up no no no no 16:0/16:1-PI+blood 18:1/20:4-PC+blood -0.606015038 -0.588235294 0 serum_phospholipids serum_phospholipids 0.262 0.582 no no no no no no 16:0/18:1-PC+blood 18:1/20:4-PC+blood 0.530827068 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.582 up up up no no no 16:0/18:1-PE+blood 18:1/20:4-PC+blood -0.50075188 -0.730392157 0 serum_phospholipids serum_phospholipids 0.000107 0.582 up up no no no no 16:0/18:2-PI+blood 18:1/20:4-PC+blood -0.697744361 -0.75245098 -0.414017094 serum_phospholipids serum_phospholipids 0.269 0.582 no no no no no no 16:0/20:4-PC+blood 18:1/20:4-PC+blood 0.693233083 0.681372549 0.746324786 serum_phospholipids serum_phospholipids 0.0262 0.582 no up no no no no 16:0/20:5-PG+blood 18:1/20:4-PC+blood 0.765413534 0 0 serum_phospholipids serum_phospholipids 0.00656 0.582 no up no no no no 16:0/22:6-PC+blood 18:1/20:4-PC+blood 0 0.786764706 0 serum_phospholipids serum_phospholipids 4.53E-05 0.582 no up up no no no 16:1/16:0-PC+blood 18:1/20:4-PC+blood 0 0.610294118 0 serum_phospholipids serum_phospholipids 0.0215 0.582 no up up no no no 16:1/16:1-PC+blood 18:1/20:4-PC+blood 0.603007519 0 0 serum_phospholipids serum_phospholipids 0.0177 0.582 no no up no no no 16:1/18:1-PG+blood 18:1/20:4-PC+blood 0.455639098 0 0 serum_phospholipids serum_phospholipids 3.21E-05 0.582 no up up no no no 18:0/16:0-PC+blood 18:1/20:4-PC+blood 0.559398496 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.582 up up up no no no 18:0/18:0-PE+blood 18:1/20:4-PC+blood 0 -0.732843137 0 serum_phospholipids serum_phospholipids 0.00896 0.582 up up no no no no 18:0/18:1-PE+blood 18:1/20:4-PC+blood 0 -0.732843137 0 serum_phospholipids serum_phospholipids 0.00716 0.582 up up no no no no 18:0/18:1-PI+blood 18:1/20:4-PC+blood 0 -0.546568627 0 serum_phospholipids serum_phospholipids 0.599 0.582 no no no no no no 18:0/18:2-PC+blood 18:1/20:4-PC+blood 0 0 0.401025641 serum_phospholipids serum_phospholipids 1.74E-06 0.582 no up up no no no 18:0/20:4-PC+blood 18:1/20:4-PC+blood 0.839097744 0.892156863 0.871452991 serum_phospholipids serum_phospholipids 0.454 0.582 no no no no no no 18:0/20:4-PI+blood 18:1/20:4-PC+blood 0.491729323 0 0 serum_phospholipids serum_phospholipids 0.167 0.582 no no no no no no 18:0/20:5-PC+blood 18:1/20:4-PC+blood 0 0.909313725 0.656752137 serum_phospholipids serum_phospholipids 0.17 0.582 no no no no no no 18:0/22:6-PC+blood 18:1/20:4-PC+blood 0 0.649509804 0 serum_phospholipids serum_phospholipids 0.0775 0.582 no no up no no no 18:1/16:0-PC+blood 18:1/20:4-PC+blood 0 0 0.412649573 serum_phospholipids serum_phospholipids 2.43E-05 0.582 no up up no no no 18:1/16:0-PE+blood 18:1/20:4-PC+blood 0 -0.720588235 0 serum_phospholipids serum_phospholipids 0.000182 0.582 up up no no no no 18:1/16:0-PI+blood 18:1/20:4-PC+blood 0 -0.671568627 -0.482393162 serum_phospholipids serum_phospholipids 0.793 0.582 no no no no no no 18:1/16:1-PE+blood 18:1/20:4-PC+blood -0.618045113 -0.710784314 0 serum_phospholipids serum_phospholipids 0.000184 0.582 up up no no no no 18:1/18:0-PE+blood 18:1/20:4-PC+blood -0.485714286 -0.779411765 0 serum_phospholipids serum_phospholipids 1.39E-06 0.582 up up no no no no 18:1/18:0-PI+blood 18:1/20:4-PC+blood 0 0 -0.493333333 serum_phospholipids serum_phospholipids 0.0931 0.582 no no up no no no 18:1/18:1-PE+blood 18:1/20:4-PC+blood -0.491729323 -0.68872549 0 serum_phospholipids serum_phospholipids 1.03E-05 0.582 up up no no no no 18:1/18:2-PE+blood 18:1/20:4-PC+blood 0 -0.781862745 0 serum_phospholipids serum_phospholipids 0.000293 0.582 up up no no no no 18:1/20:3-PC+blood 18:1/20:4-PC+blood 0 0 0.481709402 serum_phospholipids serum_phospholipids 0.00872 0.582 no up up no no no Aldosterone synthesis and secretion 18:1/20:4-PC+blood 0 0 -0.441538462 kegg serum_phospholipids NA 0.582 no up up no no no Arginine and proline metabolism 18:1/20:4-PC+blood 0.466666667 0 0 kegg serum_phospholipids NA 0.582 no up no no no no Autophagy - animal 18:1/20:4-PC+blood 0 0 0.413846154 kegg serum_phospholipids NA 0.582 no no no no no no Axon guidance 18:1/20:4-PC+blood 0 -0.532352941 0 kegg serum_phospholipids NA 0.582 no up up no no no B cell receptor signaling pathway 18:1/20:4-PC+blood 0.554385965 0 0 kegg serum_phospholipids NA 0.582 no no no no no no Biosynthesis of amino acids 18:1/20:4-PC+blood 0 0 0.424615385 kegg serum_phospholipids NA 0.582 no no no no no no Biosynthesis of cofactors 18:1/20:4-PC+blood -0.587719298 0 0 kegg serum_phospholipids NA 0.582 no no no no no no Calcium signaling pathway 18:1/20:4-PC+blood 0 0 -0.461538462 kegg serum_phospholipids NA 0.582 no up up no no no Carbon metabolism 18:1/20:4-PC+blood 0 0 0.567692308 kegg serum_phospholipids NA 0.582 no no no no no no Cholinergic synapse 18:1/20:4-PC+blood 0 0.535294118 0 kegg serum_phospholipids NA 0.582 no no no no no no Circadian entrainment 18:1/20:4-PC+blood -0.496491228 0 0 kegg serum_phospholipids NA 0.582 no up up no no no Cortisol synthesis and secretion 18:1/20:4-PC+blood 0 0 -0.42 kegg serum_phospholipids NA 0.582 no no up no no no Epithelial cell signaling in Helicobacter pylori infection 18:1/20:4-PC+blood 0.519298246 0 0 kegg serum_phospholipids NA 0.582 no no no no no no Epstein-Barr virus infection 18:1/20:4-PC+blood 0 -0.502941176 0 kegg serum_phospholipids NA 0.582 no no no no no no Estrogen signaling pathway 18:1/20:4-PC+blood -0.480701754 0 0 kegg serum_phospholipids NA 0.582 no no no no no no Gap junction 18:1/20:4-PC+blood -0.51754386 0 0 kegg serum_phospholipids NA 0.582 no no no no no no Glucagon signaling pathway 18:1/20:4-PC+blood -0.466666667 0 0 kegg serum_phospholipids NA 0.582 no no no no no no "Glycine, serine and threonine metabolism" 18:1/20:4-PC+blood -0.563157895 0 0 kegg serum_phospholipids NA 0.582 no up no no no no Glycolysis / Gluconeogenesis 18:1/20:4-PC+blood 0 0 0.442307692 kegg serum_phospholipids NA 0.582 no no no no no no IL-17 signaling pathway 18:1/20:4-PC+blood 0.477192982 0 0 kegg serum_phospholipids NA 0.582 no no no no no no Kaposi sarcoma-associated herpesvirus infection 18:1/20:4-PC+blood 0 -0.647058824 0 kegg serum_phospholipids NA 0.582 no no dn no no no Lipid and atherosclerosis 18:1/20:4-PC+blood 0.477192982 0 0 kegg serum_phospholipids NA 0.582 no no no no no no Lysosome 18:1/20:4-PC+blood 0.49122807 0 0 kegg serum_phospholipids NA 0.582 no no no no no no MAPK signaling pathway 18:1/20:4-PC+blood 0 0.714705882 0 kegg serum_phospholipids NA 0.582 no no no no no no Melanogenesis 18:1/20:4-PC+blood -0.5 0 0 kegg serum_phospholipids NA 0.582 no no no no no no Morphine addiction 18:1/20:4-PC+blood 0 0 -0.405384615 kegg serum_phospholipids NA 0.582 no up up no no no NOD-like receptor signaling pathway 18:1/20:4-PC+blood 0.522807018 0 0 kegg serum_phospholipids NA 0.582 no no no no no no Non-alcoholic fatty liver disease 18:1/20:4-PC+blood 0 -0.576470588 0 kegg serum_phospholipids NA 0.582 no no no no no no Parabacteroides 18:1/20:4-PC+blood 0 0.556372549 0 Genus serum_phospholipids 4.19E-05 0.582 no up up no no no Parkinson disease 18:1/20:4-PC+blood 0 -0.505882353 0 kegg serum_phospholipids NA 0.582 no no no no no no Peroxisome 18:1/20:4-PC+blood 0 0 0.420769231 kegg serum_phospholipids NA 0.582 no no no no no no Porphyrin and chlorophyll metabolism 18:1/20:4-PC+blood -0.464912281 0 0 kegg serum_phospholipids NA 0.582 no no no no no no Prevotella 18:1/20:4-PC+blood -0.611021408 0 0 acetate-producing Genus serum_phospholipids 0.287 0.582 no no no no no no Renin secretion 18:1/20:4-PC+blood -0.587719298 0 0 kegg serum_phospholipids NA 0.582 no no no no no no Ruminococcus 18:1/20:4-PC+blood 0 -0.697731584 0 Genus serum_phospholipids 0.0679 0.582 no no dn no no no Shigellosis 18:1/20:4-PC+blood 0 -0.567647059 0 kegg serum_phospholipids NA 0.582 no no no no no no TCA+stool 18:1/20:4-PC+blood 0 -0.736363636 0 stool_bileacids serum_phospholipids 0.458 0.582 no no no no no no Th1 and Th2 cell differentiation 18:1/20:4-PC+blood 0.515789474 0 0 kegg serum_phospholipids NA 0.582 no no no no no no Toll-like receptor signaling pathway 18:1/20:4-PC+blood 0.478947368 0 0 yes kegg serum_phospholipids NA 0.582 no no no no no no Vasopressin-regulated water reabsorption 18:1/20:4-PC+blood 0 0 -0.411538462 kegg serum_phospholipids NA 0.582 no no no no no no 12-HEPE+blood 18:1/20:4-PE+blood -0.539420539 0 0 serum_ARA serum_phospholipids 0.312 0.0578 no no no up no no 16:0/18:0-PS+blood 18:1/20:4-PE+blood 0.781954887 0.700980392 0 serum_phospholipids serum_phospholipids 0.377 0.0578 no no no up no no 16:0/18:1-PE+blood 18:1/20:4-PE+blood 0.454135338 0 0.688205128 serum_phospholipids serum_phospholipids 0.000107 0.0578 up up no up no no 16:0/20:4-PE+blood 18:1/20:4-PE+blood 0.55037594 0.727941176 0.797606838 serum_phospholipids serum_phospholipids 0.00139 0.0578 up up no up no no 16:0/22:6-PE+blood 18:1/20:4-PE+blood 0.801503759 0.87254902 0.74974359 serum_phospholipids serum_phospholipids 0.000934 0.0578 up up no up no no 16:1+blood 18:1/20:4-PE+blood 0 0.661764706 0 yes serum_fattyacid serum_phospholipids 0.0186 0.0578 no no dn up no no 18:0/18:0-PE+blood 18:1/20:4-PE+blood 0 0 0.477606838 serum_phospholipids serum_phospholipids 0.00896 0.0578 up up no up no no 18:0/18:0-PS+blood 18:1/20:4-PE+blood 0.682706767 0.593137255 0 serum_phospholipids serum_phospholipids 0.00617 0.0578 no up no up no no 18:0/18:1-PE+blood 18:1/20:4-PE+blood 0 0 0.498803419 serum_phospholipids serum_phospholipids 0.00716 0.0578 up up no up no no 18:0/22:6-PE+blood 18:1/20:4-PE+blood 0.607518797 0.710784314 0.643760684 serum_phospholipids serum_phospholipids 0.00022 0.0578 up up no up no no 18:1/16:0-PE+blood 18:1/20:4-PE+blood 0.446616541 0.49754902 0.714871795 serum_phospholipids serum_phospholipids 0.000182 0.0578 up up no up no no 18:1/16:1-PE+blood 18:1/20:4-PE+blood 0 0 0.709401709 serum_phospholipids serum_phospholipids 0.000184 0.0578 up up no up no no 18:1/18:0-PE+blood 18:1/20:4-PE+blood 0.587969925 0 0.753162393 serum_phospholipids serum_phospholipids 1.39E-06 0.0578 up up no up no no 18:1/18:0-PS+blood 18:1/20:4-PE+blood 0.47518797 0.487745098 0 serum_phospholipids serum_phospholipids 0.193 0.0578 no no no up no no 18:1/18:1-PE+blood 18:1/20:4-PE+blood 0.628571429 0.487745098 0.739487179 serum_phospholipids serum_phospholipids 1.03E-05 0.0578 up up no up no no 18:1/18:2-PE+blood 18:1/20:4-PE+blood 0.577443609 0 0.697777778 serum_phospholipids serum_phospholipids 0.000293 0.0578 up up no up no no "12,13-EPOME+blood" 18:1/20:4-PI+blood 0 0 -0.516284083 serum_ARA serum_phospholipids 0.901 0.192 no no no no no no 16:0/14:0-PC+blood 18:1/20:4-PI+blood 0 -0.615196078 0 serum_phospholipids serum_phospholipids 0.0206 0.192 no up up no no no 16:0/16:0-PC+blood 18:1/20:4-PI+blood 0 -0.531862745 0 serum_phospholipids serum_phospholipids 0.00079 0.192 no up up no no no 16:0/20:4-PC+blood 18:1/20:4-PI+blood 0 0 0.597264957 serum_phospholipids serum_phospholipids 0.0262 0.192 no up no no no no 16:1/18:1-PG+blood 18:1/20:4-PI+blood 0 0 -0.417435897 serum_phospholipids serum_phospholipids 3.21E-05 0.192 no up up no no no 16:1/18:2-PG+blood 18:1/20:4-PI+blood 0 0 -0.404444444 serum_phospholipids serum_phospholipids 1.40E-08 0.192 no up up no no no 18:0/20:4-PC+blood 18:1/20:4-PI+blood 0 0 0.665641026 serum_phospholipids serum_phospholipids 0.454 0.192 no no no no no no 18:0/20:4-PI+blood 18:1/20:4-PI+blood 0 0.541666667 0 serum_phospholipids serum_phospholipids 0.167 0.192 no no no no no no 18:0/20:5-PC+blood 18:1/20:4-PI+blood 0 0 0.445470085 serum_phospholipids serum_phospholipids 0.17 0.192 no no no no no no 18:0+blood 18:1/20:4-PI+blood 0 0 0.456410256 serum_fattyacid serum_phospholipids 0.344 0.192 no no no no no no 18:1/18:2-PI+blood 18:1/20:4-PI+blood 0.57443609 0.544117647 0 serum_phospholipids serum_phospholipids 0.0164 0.192 dn no up no no no 18:1/20:3-PC+blood 18:1/20:4-PI+blood 0 0 0.475555556 serum_phospholipids serum_phospholipids 0.00872 0.192 no up up no no no 18:1/20:4-PC+blood 18:1/20:4-PI+blood 0 0 0.494017094 serum_phospholipids serum_phospholipids 0.582 0.192 no no no no no no 18:1+blood 18:1/20:4-PI+blood 0 0.674019608 0 yes serum_fattyacid serum_phospholipids 0.00202 0.192 up no dn no no no 12-ketoDCA+blood 18:1/22:6-PE+blood 0 -0.576306805 0 serum_bileacids serum_phospholipids 0.517 0.0047 no no no no up no 14:0-LPC+blood 18:1/22:6-PE+blood -0.512781955 0 -0.461880342 serum_phospholipids serum_phospholipids 0.00689 0.0047 up up no no up no 14:0/18:0-PC+blood 18:1/22:6-PE+blood -0.484210526 0 0 serum_phospholipids serum_phospholipids 0.00289 0.0047 up up no no up no 14:0/18:2-PC+blood 18:1/22:6-PE+blood 0 0 -0.446153846 serum_phospholipids serum_phospholipids 0.102 0.0047 no up no no up no 14:1/18:2-PG+blood 18:1/22:6-PE+blood 0 0 -0.488547009 serum_phospholipids serum_phospholipids 0.00259 0.0047 no up up no up no 16:0/16:0-PI+blood 18:1/22:6-PE+blood 0 0 -0.403760684 serum_phospholipids serum_phospholipids 0.358 0.0047 no no no no up no 16:0/16:1-PC+blood 18:1/22:6-PE+blood -0.490225564 0 0 serum_phospholipids serum_phospholipids 0.00283 0.0047 up up no no up no 16:0/16:1-PI+blood 18:1/22:6-PE+blood 0 0 -0.424957265 serum_phospholipids serum_phospholipids 0.262 0.0047 no no no no up no 16:0/18:0-PS+blood 18:1/22:6-PE+blood 0.587969925 0.595588235 0 serum_phospholipids serum_phospholipids 0.377 0.0047 no no no no up no 16:0/18:2-PI+blood 18:1/22:6-PE+blood 0 0 -0.481025641 serum_phospholipids serum_phospholipids 0.269 0.0047 no no no no up no 16:0/20:4-PE+blood 18:1/22:6-PE+blood 0.50075188 0 0 serum_phospholipids serum_phospholipids 0.00139 0.0047 up up no no up no 16:0/22:0-PE+blood 18:1/22:6-PE+blood 0 0 0.495384615 serum_phospholipids serum_phospholipids 0.00839 0.0047 dn no up no up no 16:0/22:6-PC+blood 18:1/22:6-PE+blood 0 0 0.680683761 serum_phospholipids serum_phospholipids 4.53E-05 0.0047 no up up no up no 16:0/22:6-PE+blood 18:1/22:6-PE+blood 0.729323308 0.620098039 0.493333333 serum_phospholipids serum_phospholipids 0.000934 0.0047 up up no no up no 16:1/16:0-PC+blood 18:1/22:6-PE+blood 0 0.487745098 0.423589744 serum_phospholipids serum_phospholipids 0.0215 0.0047 no up up no up no 16:1+blood 18:1/22:6-PE+blood 0 0.651960784 0 yes serum_fattyacid serum_phospholipids 0.0186 0.0047 no no dn no up no 18:0/18:0-PS+blood 18:1/22:6-PE+blood 0.478195489 0 0 serum_phospholipids serum_phospholipids 0.00617 0.0047 no up no no up no 18:0/18:2-PI+blood 18:1/22:6-PE+blood 0 0 -0.472136752 serum_phospholipids serum_phospholipids 0.179 0.0047 no no no no up no 18:0/22:6-PC+blood 18:1/22:6-PE+blood 0 0.642156863 0.530940171 serum_phospholipids serum_phospholipids 0.0775 0.0047 no no up no up no 18:0/22:6-PE+blood 18:1/22:6-PE+blood 0.666165414 0.75245098 0.662222222 serum_phospholipids serum_phospholipids 0.00022 0.0047 up up no no up no 18:0/22:6-PI+blood 18:1/22:6-PE+blood 0 0.769607843 0 serum_phospholipids serum_phospholipids 0.425 0.0047 no no no no up no 18:1/18:0-PE+blood 18:1/22:6-PE+blood 0.49924812 0 0 serum_phospholipids serum_phospholipids 1.39E-06 0.0047 up up no no up no 18:1/18:0-PI+blood 18:1/22:6-PE+blood 0 0 -0.437264957 serum_phospholipids serum_phospholipids 0.0931 0.0047 no no up no up no 18:1/18:0-PS+blood 18:1/22:6-PE+blood 0 0.62745098 0.415384615 serum_phospholipids serum_phospholipids 0.193 0.0047 no no no no up no 18:1/18:1-PE+blood 18:1/22:6-PE+blood 0.44962406 0 0 serum_phospholipids serum_phospholipids 1.03E-05 0.0047 up up no no up no 18:1/18:2-PE+blood 18:1/22:6-PE+blood 0.472180451 0 0 serum_phospholipids serum_phospholipids 0.000293 0.0047 up up no no up no 18:1/20:4-PE+blood 18:1/22:6-PE+blood 0.8 0.558823529 0 serum_phospholipids serum_phospholipids 0.0578 0.0047 up no no no up no 18:1+blood 18:1/22:6-PE+blood 0 0.558823529 0 yes serum_fattyacid serum_phospholipids 0.00202 0.0047 up no dn no up no 12-ketoDCA+blood 18:1+blood -0.460321511 -0.536788624 0 yes serum_bileacids serum_fattyacid 0.517 0.00202 no no no up no dn "12,13-EPOME+blood" 18:1+blood 0.463509693 0 0 yes serum_ARA serum_fattyacid 0.901 0.00202 no no no up no dn 13-HODE+blood 18:1+blood 0.481203008 0 0 yes serum_ARA serum_fattyacid 0.32 0.00202 no no no up no dn 14:0+blood 18:1+blood 0 0.50245098 0 yes yes serum_fattyacid serum_fattyacid 0.00572 0.00202 up no dn up no dn 14:1/18:2-PG+blood 18:1+blood -0.470676692 0 0 yes serum_phospholipids serum_fattyacid 0.00259 0.00202 no up up up no dn 16:0/18:1-PC+blood 18:1+blood 0 0 0.591111111 yes serum_phospholipids serum_fattyacid 6.15E-07 0.00202 up up up up no dn 16:0/20:4-PE+blood 18:1+blood 0 0 0.419487179 yes serum_phospholipids serum_fattyacid 0.00139 0.00202 up up no up no dn 16:0/20:5-PG+blood 18:1+blood 0 0 -0.402393162 yes serum_phospholipids serum_fattyacid 0.00656 0.00202 no up no up no dn 16:0+blood 18:1+blood 0.772932331 0.495098039 0.554871795 yes yes serum_fattyacid serum_fattyacid 0.00876 0.00202 up no no up no dn 16:1/18:2-PG+blood 18:1+blood 0 0 -0.423589744 yes serum_phospholipids serum_fattyacid 1.40E-08 0.00202 no up up up no dn 16:1+blood 18:1+blood 0.828571429 0.568627451 0.578803419 yes yes serum_fattyacid serum_fattyacid 0.0186 0.00202 no no dn up no dn 18:0/16:0-PC+blood 18:1+blood 0 0 0.567179487 yes serum_phospholipids serum_fattyacid 9.64E-07 0.00202 up up up up no dn 18:0/20:2-PC+blood 18:1+blood 0 -0.605392157 0 yes serum_phospholipids serum_fattyacid 0.733 0.00202 no no no up no dn 18:0/20:3-PI+blood 18:1+blood 0.551879699 0 0 yes serum_phospholipids serum_fattyacid 0.377 0.00202 no no no up no dn 18:0/20:4-PI+blood 18:1+blood 0.54887218 0 0 yes serum_phospholipids serum_fattyacid 0.167 0.00202 no no no up no dn 18:0+blood 18:1+blood 0.654135338 0 0 yes serum_fattyacid serum_fattyacid 0.344 0.00202 no no no up no dn AGE-RAGE signaling pathway in diabetic complications 18:1+blood 0.626315789 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Alcoholism 18:1+blood 0 0.517647059 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn AMPK signaling pathway 18:1+blood -0.456140351 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Antigen processing and presentation 18:1+blood 0 0 0.443076923 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Arginine and proline metabolism 18:1+blood 0 0 0.475384615 yes kegg serum_fattyacid NA 0.00202 no up no up no dn Bifidobacterium 18:1+blood 0 -0.49049672 0 acetate-producing yes Genus serum_fattyacid 0.105 0.00202 no dn no up no dn Biosynthesis of amino acids 18:1+blood 0 0 0.459230769 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Biosynthesis of cofactors 18:1+blood -0.680701754 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Calcium signaling pathway 18:1+blood 0 -0.602941176 0 yes kegg serum_fattyacid NA 0.00202 no up up up no dn Carbon metabolism 18:1+blood 0 0 0.499230769 yes kegg serum_fattyacid NA 0.00202 no no no up no dn cGMP-PKG signaling pathway 18:1+blood 0.628070175 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Cholinergic synapse 18:1+blood 0.552631579 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Cushing syndrome 18:1+blood 0 0 -0.416153846 yes kegg serum_fattyacid NA 0.00202 no no up up no dn Cytokine-cytokine receptor interaction 18:1+blood 0.456140351 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Epithelial cell signaling in Helicobacter pylori infection 18:1+blood 0 0 0.427692308 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Fc epsilon RI signaling pathway 18:1+blood 0.457894737 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Fc gamma R-mediated phagocytosis 18:1+blood 0 0 0.564615385 yes kegg serum_fattyacid NA 0.00202 no no no up no dn FoxO signaling pathway 18:1+blood 0.470175439 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn GABAergic synapse 18:1+blood 0.568421053 0 0 yes kegg serum_fattyacid NA 0.00202 no up up up no dn Glioma 18:1+blood 0.635087719 0.541176471 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Glucagon signaling pathway 18:1+blood 0 0 -0.402307692 yes kegg serum_fattyacid NA 0.00202 no no no up no dn "Glycine, serine and threonine metabolism" 18:1+blood -0.596491228 0 0 yes kegg serum_fattyacid NA 0.00202 no up no up no dn HCA+stool 18:1+blood 0.620879121 0 -0.44962406 yes stool_bileacids serum_fattyacid 0.155 0.00202 no no no up no dn IL-17 signaling pathway 18:1+blood 0 0 0.443846154 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Inflammatory bowel disease 18:1+blood 0.477192982 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Leishmaniasis 18:1+blood 0 0 0.472307692 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Lipid and atherosclerosis 18:1+blood 0.671929825 0 0.62 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Long-term potentiation 18:1+blood 0.501754386 0 0 yes kegg serum_fattyacid NA 0.00202 no no up up no dn Lysosome 18:1+blood 0 0 0.406923077 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Mineral absorption 18:1+blood 0 -0.517647059 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Mitophagy - animal 18:1+blood -0.470175439 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn mRNA surveillance pathway 18:1+blood 0 0 -0.423846154 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Neutrophil extracellular trap formation 18:1+blood 0 0 0.420769231 yes kegg serum_fattyacid NA 0.00202 no no no up no dn NOD-like receptor signaling pathway 18:1+blood 0.561403509 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Olfactory transduction 18:1+blood 0.557894737 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Osteoclast differentiation 18:1+blood 0 0 0.495384615 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Peroxisome 18:1+blood 0.494736842 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Pertussis 18:1+blood 0.584210526 0 0.531538462 yes kegg serum_fattyacid NA 0.00202 no no dn up no dn Phagosome 18:1+blood 0 0 0.486153846 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Porphyrin and chlorophyll metabolism 18:1+blood -0.601754386 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn PPAR signaling pathway 18:1+blood 0 0 0.476153846 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Prolactin signaling pathway 18:1+blood 0.496491228 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Proteoglycans in cancer 18:1+blood -0.647368421 -0.555882353 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Ras signaling pathway 18:1+blood 0 0 -0.412307692 yes yes kegg serum_fattyacid NA 0.00202 no up up up no dn Rheumatoid arthritis 18:1+blood 0 0 0.433076923 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Salivary secretion 18:1+blood 0 0.514705882 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Shigellosis 18:1+blood -0.557894737 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Sphingolipid signaling pathway 18:1+blood 0.6 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Staphylococcus aureus infection 18:1+blood 0 0 0.654615385 yes kegg serum_fattyacid NA 0.00202 up no no up no dn Systemic lupus erythematosus 18:1+blood 0 0 0.627692308 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Toll-like receptor signaling pathway 18:1+blood 0 0 0.416923077 yes yes kegg serum_fattyacid NA 0.00202 no no no up no dn Toxoplasmosis 18:1+blood 0 0 0.515384615 yes kegg serum_fattyacid NA 0.00202 no no no up no dn Tuberculosis 18:1+blood 0.468421053 0 0.527692308 yes kegg serum_fattyacid NA 0.00202 no no dn up no dn Ubiquitin mediated proteolysis 18:1+blood -0.480701754 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn VEGF signaling pathway 18:1+blood 0.559649123 0 0 yes kegg serum_fattyacid NA 0.00202 no no no up no dn 13-HODE+blood 18:2-LPA+blood 0.512781955 0 0 serum_ARA serum_phospholipids 0.32 0.00684 no no no dn no up 14:0/18:2-PC+blood 18:2-LPA+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.102 0.00684 no up no dn no up 16:0-LPE+blood 18:2-LPA+blood -0.580451128 0 0 serum_phospholipids serum_phospholipids 0.0711 0.00684 up up no dn no up 16:0/14:0-PC+blood 18:2-LPA+blood 0.544360902 0 0 serum_phospholipids serum_phospholipids 0.0206 0.00684 no up up dn no up 16:0/18:0-PS+blood 18:2-LPA+blood 0 -0.49754902 0 serum_phospholipids serum_phospholipids 0.377 0.00684 no no no dn no up 16:0/18:1-PC+blood 18:2-LPA+blood 0.45112782 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.00684 up up up dn no up 16:0/20:3-PC+blood 18:2-LPA+blood 0.479699248 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.00684 no up up dn no up 16:0/20:4-PC+blood 18:2-LPA+blood 0.551879699 0 0 serum_phospholipids serum_phospholipids 0.0262 0.00684 no up no dn no up 16:0/20:5-PC+blood 18:2-LPA+blood 0 -0.539215686 0 serum_phospholipids serum_phospholipids 0.628 0.00684 no no no dn no up 16:1/16:0-PC+blood 18:2-LPA+blood 0.533834586 0 0 serum_phospholipids serum_phospholipids 0.0215 0.00684 no up up dn no up 16:1/16:1-PC+blood 18:2-LPA+blood 0.560902256 0 0 serum_phospholipids serum_phospholipids 0.0177 0.00684 no no up dn no up 18:0/16:0-PC+blood 18:2-LPA+blood 0.461654135 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.00684 up up up dn no up 18:0/18:0-PS+blood 18:2-LPA+blood 0 -0.595588235 0 serum_phospholipids serum_phospholipids 0.00617 0.00684 no up no dn no up 18:0/20:4-PC+blood 18:2-LPA+blood 0.515789474 0 0 serum_phospholipids serum_phospholipids 0.454 0.00684 no no no dn no up 18:0/22:6-PC+blood 18:2-LPA+blood 0 -0.526960784 0 serum_phospholipids serum_phospholipids 0.0775 0.00684 no no up dn no up 18:0/22:6-PE+blood 18:2-LPA+blood 0 -0.580882353 -0.45982906 serum_phospholipids serum_phospholipids 0.00022 0.00684 up up no dn no up 18:0/22:6-PI+blood 18:2-LPA+blood 0 -0.485294118 0 serum_phospholipids serum_phospholipids 0.425 0.00684 no no no dn no up 18:1/18:0-PS+blood 18:2-LPA+blood 0 -0.610294118 -0.431794872 serum_phospholipids serum_phospholipids 0.193 0.00684 no no no dn no up 18:1/18:1-PC+blood 18:2-LPA+blood 0.551879699 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.00684 no up up dn no up 18:1/18:2-PE+blood 18:2-LPA+blood -0.541353383 0 0 serum_phospholipids serum_phospholipids 0.000293 0.00684 up up no dn no up 18:1/22:6-PE+blood 18:2-LPA+blood -0.497744361 0 0 serum_phospholipids serum_phospholipids 0.0047 0.00684 no up no dn no up DCA+stool 18:2-LPA+blood 0 0 -0.610526316 stool_bileacids serum_phospholipids 0.195 0.00684 no no no dn no up HDCA+stool 18:2-LPA+blood 0.565934066 0 0 stool_bileacids serum_phospholipids 0.176 0.00684 no no no dn no up LCA+stool 18:2-LPA+blood 0.752747253 0 -0.679699248 stool_bileacids serum_phospholipids 0.314 0.00684 no no no dn no up Pancreatic cancer 18:2-LPA+blood 0 0 -0.452307692 kegg serum_phospholipids NA 0.00684 no no no dn no up Propionic acid+stool 18:2-LPA+blood 0 0 -0.553383459 yes stool_scfa serum_phospholipids 0.0436 0.00684 dn no up dn no up Protein processing in endoplasmic reticulum 18:2-LPA+blood 0 0 -0.423846154 kegg serum_phospholipids NA 0.00684 no no no dn no up Renal cell carcinoma 18:2-LPA+blood 0 0 -0.418461538 kegg serum_phospholipids NA 0.00684 no no no dn no up Ruminococcus 18:2-LPA+blood 0.584962406 0 0 acetate-producing Genus serum_phospholipids 0.335 0.00684 no no no dn no up Th1 and Th2 cell differentiation 18:2-LPA+blood 0 0 0.441538462 kegg serum_phospholipids NA 0.00684 no no no dn no up Th17 cell differentiation 18:2-LPA+blood 0 0 0.400769231 kegg serum_phospholipids NA 0.00684 no no no dn no up 13-HODE+blood 18:2-LPC+blood 0 0.507352941 0 serum_ARA serum_phospholipids 0.32 0.00743 no no no dn no up 14:0/16:0-PC+blood 18:2-LPC+blood 0 0 -0.416752137 serum_phospholipids serum_phospholipids 0.0358 0.00743 no up no dn no up 14:0/20:4-PC+blood 18:2-LPC+blood -0.562406015 0 0 serum_phospholipids serum_phospholipids 0.486 0.00743 no no no dn no up 16:0/16:0-PI+blood 18:2-LPC+blood 0 0 -0.502222222 serum_phospholipids serum_phospholipids 0.358 0.00743 no no no dn no up 16:0/16:1-PI+blood 18:2-LPC+blood 0 0 -0.433162393 serum_phospholipids serum_phospholipids 0.262 0.00743 no no no dn no up 16:0/18:0-PS+blood 18:2-LPC+blood 0 0 -0.534358974 serum_phospholipids serum_phospholipids 0.377 0.00743 no no no dn no up 16:0/18:1-PE+blood 18:2-LPC+blood 0 0 -0.515213675 serum_phospholipids serum_phospholipids 0.000107 0.00743 up up no dn no up 16:0/20:4-PE+blood 18:2-LPC+blood 0 0 -0.483760684 serum_phospholipids serum_phospholipids 0.00139 0.00743 up up no dn no up 16:0/20:4-PI+blood 18:2-LPC+blood 0 -0.526960784 -0.446153846 serum_phospholipids serum_phospholipids 0.558 0.00743 no no no dn no up 16:0/20:5-PC+blood 18:2-LPC+blood -0.57443609 0 0 serum_phospholipids serum_phospholipids 0.628 0.00743 no no no dn no up 16:0/22:6-PE+blood 18:2-LPC+blood 0 0 -0.472820513 serum_phospholipids serum_phospholipids 0.000934 0.00743 up up no dn no up 16:0+blood 18:2-LPC+blood 0 0 -0.474188034 yes serum_fattyacid serum_phospholipids 0.00876 0.00743 up no no dn no up 16:1+blood 18:2-LPC+blood 0 0 -0.42974359 yes serum_fattyacid serum_phospholipids 0.0186 0.00743 no no dn dn no up 18:0-LPC+blood 18:2-LPC+blood 0 0 0.484444444 serum_phospholipids serum_phospholipids 0.554 0.00743 no no no dn no up 18:0/18:0-PC+blood 18:2-LPC+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.426 0.00743 no no no dn no up 18:0/18:0-PS+blood 18:2-LPC+blood -0.44962406 0 -0.525470085 serum_phospholipids serum_phospholipids 0.00617 0.00743 no up no dn no up 18:0/18:1-PC+blood 18:2-LPC+blood 0 -0.539215686 0 serum_phospholipids serum_phospholipids 0.393 0.00743 no no no dn no up 18:0/18:1-PG+blood 18:2-LPC+blood 0 -0.482843137 -0.586324786 serum_phospholipids serum_phospholipids 0.000842 0.00743 no up no dn no up 18:0/18:2-PC+blood 18:2-LPC+blood 0.454135338 0 0 serum_phospholipids serum_phospholipids 1.74E-06 0.00743 no up up dn no up 18:0/20:2-PC+blood 18:2-LPC+blood 0 -0.482843137 0.416752137 serum_phospholipids serum_phospholipids 0.733 0.00743 no no no dn no up 18:0/20:3-PC+blood 18:2-LPC+blood 0 -0.629901961 0 serum_phospholipids serum_phospholipids 0.0682 0.00743 no up no dn no up 18:0/20:4-PI+blood 18:2-LPC+blood 0 0 -0.496752137 serum_phospholipids serum_phospholipids 0.167 0.00743 no no no dn no up 18:0/22:6-PC+blood 18:2-LPC+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 0.0775 0.00743 no no up dn no up 18:0/22:6-PE+blood 18:2-LPC+blood 0 0 -0.522735043 serum_phospholipids serum_phospholipids 0.00022 0.00743 up up no dn no up 18:0/22:6-PI+blood 18:2-LPC+blood 0 -0.62254902 -0.433162393 serum_phospholipids serum_phospholipids 0.425 0.00743 no no no dn no up 18:1-LPC+blood 18:2-LPC+blood 0.661654135 0 0.79965812 serum_phospholipids serum_phospholipids 0.179 0.00743 no no no dn no up 18:1-LPE+blood 18:2-LPC+blood 0 0 0.676581197 serum_phospholipids serum_phospholipids 0.117 0.00743 no no no dn no up 18:1/16:1-PE+blood 18:2-LPC+blood 0 0 -0.518632479 serum_phospholipids serum_phospholipids 0.000184 0.00743 up up no dn no up 18:1/18:1-PI+blood 18:2-LPC+blood 0.509774436 0 0 serum_phospholipids serum_phospholipids 0.111 0.00743 dn no no dn no up 18:1/18:2-PI+blood 18:2-LPC+blood 0 0 0.452991453 serum_phospholipids serum_phospholipids 0.0164 0.00743 dn no up dn no up 18:1/22:6-PE+blood 18:2-LPC+blood 0 -0.529411765 0 serum_phospholipids serum_phospholipids 0.0047 0.00743 no up no dn no up Adlercreutzia 18:2-LPC+blood 0 0 0.50770783 Genus serum_phospholipids 0.548 0.00743 no no no dn no up Arginine and proline metabolism 18:2-LPC+blood 0 0 -0.637692308 kegg serum_phospholipids NA 0.00743 no up no dn no up Blautia 18:2-LPC+blood -0.487218045 0 0 acetate-producing Genus serum_phospholipids 1.36E-05 0.00743 up dn dn dn no up Butyricicoccus 18:2-LPC+blood -0.455234657 0 0 butyrate-producing Genus serum_phospholipids 0.852 0.00743 no no no dn no up Clostridium 18:2-LPC+blood 0 -0.638871978 0 Genus serum_phospholipids 0.925 0.00743 no no no dn no up Collinsella 18:2-LPC+blood -0.58132596 0 0 Genus serum_phospholipids 0.128 0.00743 no no no dn no up Coprococcus 18:2-LPC+blood -0.578947368 0 0 butyrate-producing Genus serum_phospholipids 0.612 0.00743 no no no dn no up Cytosolic DNA-sensing pathway 18:2-LPC+blood 0 0 -0.414615385 kegg serum_phospholipids NA 0.00743 no no no dn no up Dorea 18:2-LPC+blood -0.532330827 0 0 Genus serum_phospholipids 0.00362 0.00743 up no dn dn no up Epithelial cell signaling in Helicobacter pylori infection 18:2-LPC+blood 0 0 -0.401538462 kegg serum_phospholipids NA 0.00743 no no no dn no up FoxO signaling pathway 18:2-LPC+blood 0 0 0.434615385 kegg serum_phospholipids NA 0.00743 no no no dn no up HDCA+stool 18:2-LPC+blood 0 0 -0.470676692 stool_bileacids serum_phospholipids 0.176 0.00743 no no no dn no up Hematopoietic cell lineage 18:2-LPC+blood 0 0 0.416153846 kegg serum_phospholipids NA 0.00743 no no no dn no up Measles 18:2-LPC+blood 0 0 -0.463076923 kegg serum_phospholipids NA 0.00743 no no no dn no up Necroptosis 18:2-LPC+blood 0 0.573529412 0 kegg serum_phospholipids NA 0.00743 no no no dn no up nutriCA+stool 18:2-LPC+blood 0 -0.84407222 0 stool_bileacids serum_phospholipids 0.481 0.00743 no no no dn no up Osteoclast differentiation 18:2-LPC+blood 0 0 -0.427692308 kegg serum_phospholipids NA 0.00743 no no no dn no up Platinum drug resistance 18:2-LPC+blood 0 0 0.481538462 kegg serum_phospholipids NA 0.00743 no no no dn no up PPAR signaling pathway 18:2-LPC+blood 0 0 -0.528461538 kegg serum_phospholipids NA 0.00743 no no no dn no up Primary immunodeficiency 18:2-LPC+blood 0 0 0.403076923 kegg serum_phospholipids NA 0.00743 no no no dn no up Prolactin signaling pathway 18:2-LPC+blood 0 0 -0.400769231 kegg serum_phospholipids NA 0.00743 no no no dn no up Purine metabolism 18:2-LPC+blood 0 0 -0.503076923 kegg serum_phospholipids NA 0.00743 no no no dn no up Ras signaling pathway 18:2-LPC+blood 0 0 0.401538462 yes kegg serum_phospholipids NA 0.00743 no up up dn no up Ruminococcus 18:2-LPC+blood 0 0 -0.404161329 Genus serum_phospholipids 0.0679 0.00743 no no dn dn no up TCA+stool 18:2-LPC+blood -0.624484772 0 0 stool_bileacids serum_phospholipids 0.458 0.00743 no no no dn no up Toll-like receptor signaling pathway 18:2-LPC+blood 0 0 -0.430769231 yes kegg serum_phospholipids NA 0.00743 no no no dn no up 13-HODE+blood 18:2-LPE+blood 0 0.571078431 0 serum_ARA serum_phospholipids 0.32 0.112 no no no no no no 16:0/18:0-PS+blood 18:2-LPE+blood 0 -0.5 0 serum_phospholipids serum_phospholipids 0.377 0.112 no no no no no no 16:0/20:5-PC+blood 18:2-LPE+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.628 0.112 no no no no no no 16:0/20:5-PG+blood 18:2-LPE+blood -0.559398496 0 0 serum_phospholipids serum_phospholipids 0.00656 0.112 no up no no no no 16:0/22:0-PE+blood 18:2-LPE+blood 0 -0.517156863 0 serum_phospholipids serum_phospholipids 0.00839 0.112 dn no up no no no 16:1-LPC+blood 18:2-LPE+blood 0.488721805 0 0 serum_phospholipids serum_phospholipids 0.0241 0.112 no up no no no no 18:0-LPC+blood 18:2-LPE+blood 0 0 0.424273504 serum_phospholipids serum_phospholipids 0.554 0.112 no no no no no no 18:0-LPE+blood 18:2-LPE+blood 0 0 0.484444444 serum_phospholipids serum_phospholipids 0.491 0.112 no no no no no no 18:0/18:0-PS+blood 18:2-LPE+blood -0.505263158 0 0 serum_phospholipids serum_phospholipids 0.00617 0.112 no up no no no no 18:0/20:5-PC+blood 18:2-LPE+blood 0 -0.556372549 0 serum_phospholipids serum_phospholipids 0.17 0.112 no no no no no no 18:0/22:6-PC+blood 18:2-LPE+blood 0 -0.607843137 0 serum_phospholipids serum_phospholipids 0.0775 0.112 no no up no no no 18:0/22:6-PE+blood 18:2-LPE+blood 0 -0.605392157 0 serum_phospholipids serum_phospholipids 0.00022 0.112 up up no no no no 18:0/22:6-PI+blood 18:2-LPE+blood 0 -0.654411765 0 serum_phospholipids serum_phospholipids 0.425 0.112 no no no no no no 18:1-LPC+blood 18:2-LPE+blood 0 0 0.582222222 serum_phospholipids serum_phospholipids 0.179 0.112 no no no no no no 18:1-LPE+blood 18:2-LPE+blood 0.690225564 0.519607843 0.762735043 serum_phospholipids serum_phospholipids 0.117 0.112 no no no no no no 18:1/18:0-PI+blood 18:2-LPE+blood 0 0 0.463247863 serum_phospholipids serum_phospholipids 0.0931 0.112 no no up no no no 18:1/18:0-PS+blood 18:2-LPE+blood -0.446616541 0 0 serum_phospholipids serum_phospholipids 0.193 0.112 no no no no no no 18:1/20:4-PC+blood 18:2-LPE+blood -0.503759398 -0.49754902 -0.407863248 serum_phospholipids serum_phospholipids 0.582 0.112 no no no no no no 18:2-LPA+blood 18:2-LPE+blood 0 0.524509804 0 serum_phospholipids serum_phospholipids 0.00684 0.112 dn no up no no no 18:2-LPC+blood 18:2-LPE+blood 0.619548872 0.512254902 0.676581197 serum_phospholipids serum_phospholipids 0.00743 0.112 dn no up no no no 4-hydroxybenzoic acid+stool 18:2-LPE+blood 0 0 0.556390977 stool_cometabolism serum_phospholipids 0.0536 0.112 no dn no no no no Arginine and proline metabolism 18:2-LPE+blood 0 0 -0.413076923 kegg serum_phospholipids NA 0.112 no up no no no no Axon guidance 18:2-LPE+blood 0 0 0.448461538 kegg serum_phospholipids NA 0.112 no up up no no no Bifidobacterium 18:2-LPE+blood -0.506205376 0 0 acetate-producing Genus serum_phospholipids 0.105 0.112 no dn no no no no Blautia 18:2-LPE+blood -0.57443609 0 0 acetate-producing Genus serum_phospholipids 1.36E-05 0.112 up dn dn no no no CDCA+stool 18:2-LPE+blood 0 0 0.47518797 stool_bileacids serum_phospholipids 0.663 0.112 no no no no no no Cell cycle 18:2-LPE+blood 0 0 0.410769231 kegg serum_phospholipids NA 0.112 no no no no no no Chagas disease 18:2-LPE+blood 0.471929825 0 0 kegg serum_phospholipids NA 0.112 no no no no no no Chronic myeloid leukemia 18:2-LPE+blood 0.505263158 0 0 kegg serum_phospholipids NA 0.112 no no no no no no Clostridium 18:2-LPE+blood -0.446515883 0 0 Genus serum_phospholipids 0.925 0.112 no no no no no no Coprococcus 18:2-LPE+blood -0.493233083 0 0 butyrate-producing Genus serum_phospholipids 0.612 0.112 no no no no no no ErbB signaling pathway 18:2-LPE+blood 0.505263158 0 0 kegg serum_phospholipids NA 0.112 no no no no no no Gastric cancer 18:2-LPE+blood 0 0 0.408461538 kegg serum_phospholipids NA 0.112 no no no no no no Gemmiger 18:2-LPE+blood 0 0 -0.494521273 butyrate-producing Genus serum_phospholipids 0.595 0.112 no no no no no no Glutathione metabolism 18:2-LPE+blood 0 0 -0.400769231 kegg serum_phospholipids NA 0.112 no no no no no no L-Phenylalanine+stool 18:2-LPE+blood 0 0 -0.557894737 stool_cometabolism serum_phospholipids 0.398 0.112 no no no no no no L-Tryptophan+stool 18:2-LPE+blood 0 0 -0.609022556 stool_cometabolism serum_phospholipids 0.557 0.112 no no no no no no L-Tyrosine+stool 18:2-LPE+blood 0 0 -0.460150376 stool_cometabolism serum_phospholipids 0.44 0.112 no no no no no no Long-term potentiation 18:2-LPE+blood 0 0 0.412307692 kegg serum_phospholipids NA 0.112 no no up no no no Longevity regulating pathway 18:2-LPE+blood 0.521052632 0 0 kegg serum_phospholipids NA 0.112 no no no no no no Mitophagy - animal 18:2-LPE+blood 0.461403509 0 0 kegg serum_phospholipids NA 0.112 no no no no no no Oscillospira 18:2-LPE+blood 0 0 -0.502222222 LPS-producing Genus serum_phospholipids 0.62 0.112 no no no no no no Peroxisome 18:2-LPE+blood 0 0 -0.46 kegg serum_phospholipids NA 0.112 no no no no no no Phenylacetic acid+stool 18:2-LPE+blood 0 0 -0.682706767 stool_cometabolism serum_phospholipids 0.785 0.112 no no no no no no Prostate cancer 18:2-LPE+blood 0.463157895 0 0 kegg serum_phospholipids NA 0.112 no no no no no no Purine metabolism 18:2-LPE+blood 0 0 -0.510769231 kegg serum_phospholipids NA 0.112 no no no no no no Relaxin signaling pathway 18:2-LPE+blood 0.49122807 0 0 kegg serum_phospholipids NA 0.112 no no no no no no Renal cell carcinoma 18:2-LPE+blood 0.512280702 0 0 kegg serum_phospholipids NA 0.112 no no no no no no Retrograde endocannabinoid signaling 18:2-LPE+blood 0 0 0.412307692 kegg serum_phospholipids NA 0.112 no no up no no no Signaling pathways regulating pluripotency of stem cells 18:2-LPE+blood 0 0 0.426923077 kegg serum_phospholipids NA 0.112 no no no no no no 12-ketoDCA+blood 18:2/16:0-PC+blood -0.448490818 0 0 serum_bileacids serum_phospholipids 0.517 8.67E-05 no no no no up up 13-HODE+blood 18:2/16:0-PC+blood 0 0.519607843 0 serum_ARA serum_phospholipids 0.32 8.67E-05 no no no no up up 16:0-LPE+blood 18:2/16:0-PC+blood -0.461654135 0 0 serum_phospholipids serum_phospholipids 0.0711 8.67E-05 up up no no up up 16:0/14:0-PC+blood 18:2/16:0-PC+blood 0.663157895 0.539215686 0.697094017 serum_phospholipids serum_phospholipids 0.0206 8.67E-05 no up up no up up 16:0/16:0-PC+blood 18:2/16:0-PC+blood 0.732330827 0 0.64991453 serum_phospholipids serum_phospholipids 0.00079 8.67E-05 no up up no up up 16:0/16:0-PI+blood 18:2/16:0-PC+blood -0.512781955 -0.490196078 0 serum_phospholipids serum_phospholipids 0.358 8.67E-05 no no no no up up 16:0/16:1-PI+blood 18:2/16:0-PC+blood -0.747368421 -0.632352941 0 serum_phospholipids serum_phospholipids 0.262 8.67E-05 no no no no up up 16:0/18:0-PC+blood 18:2/16:0-PC+blood 0.509774436 0 0.574700855 serum_phospholipids serum_phospholipids 0.521 8.67E-05 no no no no up up 16:0/18:0-PS+blood 18:2/16:0-PC+blood 0 0 -0.414017094 serum_phospholipids serum_phospholipids 0.377 8.67E-05 no no no no up up 16:0/18:1-PC+blood 18:2/16:0-PC+blood 0.714285714 0.659313725 0 serum_phospholipids serum_phospholipids 6.15E-07 8.67E-05 up up up no up up 16:0/18:1-PE+blood 18:2/16:0-PC+blood -0.488721805 0 0 serum_phospholipids serum_phospholipids 0.000107 8.67E-05 up up no no up up 16:0/18:2-PC+blood 18:2/16:0-PC+blood 0.781954887 0.715686275 0.624615385 serum_phospholipids serum_phospholipids 3.24E-06 8.67E-05 no up up no up up 16:0/20:3-PC+blood 18:2/16:0-PC+blood 0.735338346 0 0 serum_phospholipids serum_phospholipids 5.43E-06 8.67E-05 no up up no up up 16:0/20:4-PC+blood 18:2/16:0-PC+blood 0.566917293 0.526960784 0.578119658 serum_phospholipids serum_phospholipids 0.0262 8.67E-05 no up no no up up 16:0/20:4-PI+blood 18:2/16:0-PC+blood -0.627067669 -0.632352941 0 serum_phospholipids serum_phospholipids 0.558 8.67E-05 no no no no up up 16:0/22:6-PC+blood 18:2/16:0-PC+blood 0.562406015 0.517156863 0.552820513 serum_phospholipids serum_phospholipids 4.53E-05 8.67E-05 no up up no up up 16:0+blood 18:2/16:0-PC+blood 0 0.519607843 0 yes serum_fattyacid serum_phospholipids 0.00876 8.67E-05 up no no no up up 16:1/16:0-PC+blood 18:2/16:0-PC+blood 0.730827068 0.519607843 0.644444444 serum_phospholipids serum_phospholipids 0.0215 8.67E-05 no up up no up up 16:1/16:1-PC+blood 18:2/16:0-PC+blood 0.65112782 0 0.533675214 serum_phospholipids serum_phospholipids 0.0177 8.67E-05 no no up no up up 16:1/18:1-PG+blood 18:2/16:0-PC+blood 0 0 -0.401025641 serum_phospholipids serum_phospholipids 3.21E-05 8.67E-05 no up up no up up 16:1/18:2-PG+blood 18:2/16:0-PC+blood 0.578947368 0 0 serum_phospholipids serum_phospholipids 1.40E-08 8.67E-05 no up up no up up 18:0-LPA+blood 18:2/16:0-PC+blood 0 0 -0.502905983 serum_phospholipids serum_phospholipids 0.0725 8.67E-05 no dn no no up up 18:0-LPC+blood 18:2/16:0-PC+blood 0 -0.62254902 0 serum_phospholipids serum_phospholipids 0.554 8.67E-05 no no no no up up 18:0/16:0-PC+blood 18:2/16:0-PC+blood 0.69924812 0.659313725 0 serum_phospholipids serum_phospholipids 9.64E-07 8.67E-05 up up up no up up 18:0/18:0-PE+blood 18:2/16:0-PC+blood -0.535338346 0 0 serum_phospholipids serum_phospholipids 0.00896 8.67E-05 up up no no up up 18:0/18:1-PE+blood 18:2/16:0-PC+blood -0.527819549 0 0 serum_phospholipids serum_phospholipids 0.00716 8.67E-05 up up no no up up 18:0/18:1-PI+blood 18:2/16:0-PC+blood 0 0 -0.405128205 serum_phospholipids serum_phospholipids 0.599 8.67E-05 no no no no up up 18:0/18:2-PC+blood 18:2/16:0-PC+blood 0.896240602 0.632352941 0.789401709 serum_phospholipids serum_phospholipids 1.74E-06 8.67E-05 no up up no up up 18:0/20:3-PC+blood 18:2/16:0-PC+blood 0 -0.539215686 0 serum_phospholipids serum_phospholipids 0.0682 8.67E-05 no up no no up up 18:0/20:4-PC+blood 18:2/16:0-PC+blood 0.536842105 0 0.490598291 serum_phospholipids serum_phospholipids 0.454 8.67E-05 no no no no up up 18:0/20:5-PC+blood 18:2/16:0-PC+blood 0 0 0.626666667 serum_phospholipids serum_phospholipids 0.17 8.67E-05 no no no no up up 18:1/16:0-PC+blood 18:2/16:0-PC+blood 0.756390977 0.732843137 0.619145299 serum_phospholipids serum_phospholipids 2.43E-05 8.67E-05 no up up no up up 18:1/16:0-PE+blood 18:2/16:0-PC+blood -0.518796992 0 0 serum_phospholipids serum_phospholipids 0.000182 8.67E-05 up up no no up up 18:1/16:0-PI+blood 18:2/16:0-PC+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 0.793 8.67E-05 no no no no up up 18:1/16:1-PE+blood 18:2/16:0-PC+blood -0.490225564 0 0 serum_phospholipids serum_phospholipids 0.000184 8.67E-05 up up no no up up 18:1/18:0-PC+blood 18:2/16:0-PC+blood 0.891729323 0.639705882 0.797606838 serum_phospholipids serum_phospholipids 1.83E-06 8.67E-05 no up up no up up 18:1/18:1-PC+blood 18:2/16:0-PC+blood 0.645112782 0 0 serum_phospholipids serum_phospholipids 1.34E-05 8.67E-05 no up up no up up 18:1/18:1-PI+blood 18:2/16:0-PC+blood 0 -0.632352941 0 serum_phospholipids serum_phospholipids 0.111 8.67E-05 dn no no no up up 18:1/18:2-PG+blood 18:2/16:0-PC+blood 0.6 0 0 serum_phospholipids serum_phospholipids 5.58E-07 8.67E-05 no up up no up up 18:2-LPC+blood 18:2/16:0-PC+blood 0.542857143 0 0 serum_phospholipids serum_phospholipids 0.00743 8.67E-05 dn no up no up up 3-(3-Hydroxyphenyl)propanoic acid+stool 18:2/16:0-PC+blood 0 0 -0.541353383 stool_cometabolism serum_phospholipids 0.33 8.67E-05 no no no no up up Adherens junction 18:2/16:0-PC+blood 0 0 -0.453846154 kegg serum_phospholipids NA 8.67E-05 no no no no up up Alistipes 18:2/16:0-PC+blood 0 -0.543225117 0 Genus serum_phospholipids 0.0114 8.67E-05 no up no no up up Allograft rejection 18:2/16:0-PC+blood 0 0 -0.516923077 kegg serum_phospholipids NA 8.67E-05 no no no no up up Arrhythmogenic right ventricular cardiomyopathy 18:2/16:0-PC+blood 0 0 -0.450769231 kegg serum_phospholipids NA 8.67E-05 no up up no up up Autoimmune thyroid disease 18:2/16:0-PC+blood 0 0 -0.516923077 kegg serum_phospholipids NA 8.67E-05 no no no no up up Butyricicoccus 18:2/16:0-PC+blood -0.509933395 0 -0.438953875 butyrate-producing Genus serum_phospholipids 0.852 8.67E-05 no no no no up up Cardiac muscle contraction 18:2/16:0-PC+blood 0 0 -0.442307692 kegg serum_phospholipids NA 8.67E-05 no no up no up up Cell adhesion molecules 18:2/16:0-PC+blood 0 0 -0.455384615 kegg serum_phospholipids NA 8.67E-05 no no no no up up Cellular senescence 18:2/16:0-PC+blood 0 0 -0.436923077 kegg serum_phospholipids NA 8.67E-05 no no no no up up Central carbon metabolism in cancer 18:2/16:0-PC+blood 0 -0.694117647 0.411538462 kegg serum_phospholipids NA 8.67E-05 no no no no up up Diabetic cardiomyopathy 18:2/16:0-PC+blood 0 0 -0.414615385 kegg serum_phospholipids NA 8.67E-05 no no no no up up Dilated cardiomyopathy 18:2/16:0-PC+blood 0 0 -0.426153846 kegg serum_phospholipids NA 8.67E-05 no up up no up up Endocytosis 18:2/16:0-PC+blood 0 0 -0.408461538 kegg serum_phospholipids NA 8.67E-05 no no no no up up Fluid shear stress and atherosclerosis 18:2/16:0-PC+blood 0 0 -0.43 kegg serum_phospholipids NA 8.67E-05 no no no no up up Gastric acid secretion 18:2/16:0-PC+blood 0 0 -0.436923077 kegg serum_phospholipids NA 8.67E-05 no no no no up up Graft-versus-host disease 18:2/16:0-PC+blood 0 0 -0.500769231 kegg serum_phospholipids NA 8.67E-05 no no no no up up Hepatocellular carcinoma 18:2/16:0-PC+blood 0 0 -0.480769231 kegg serum_phospholipids NA 8.67E-05 no no no no up up Hippo signaling pathway 18:2/16:0-PC+blood 0 0 -0.43 kegg serum_phospholipids NA 8.67E-05 no no no no up up Human papillomavirus infection 18:2/16:0-PC+blood 0 0 -0.466153846 kegg serum_phospholipids NA 8.67E-05 no no no no up up Hypertrophic cardiomyopathy 18:2/16:0-PC+blood 0 0 -0.43 kegg serum_phospholipids NA 8.67E-05 no up up no up up Inflammatory bowel disease 18:2/16:0-PC+blood 0 0 -0.41 kegg serum_phospholipids NA 8.67E-05 no no no no up up Influenza A 18:2/16:0-PC+blood 0 0 -0.434615385 kegg serum_phospholipids NA 8.67E-05 no no no no up up L-Phenylalanine+stool 18:2/16:0-PC+blood 0 0 0.469172932 stool_cometabolism serum_phospholipids 0.398 8.67E-05 no no no no up up L-Tyrosine+stool 18:2/16:0-PC+blood 0 0 0.488721805 stool_cometabolism serum_phospholipids 0.44 8.67E-05 no no no no up up Malaria 18:2/16:0-PC+blood 0 0 0.520769231 kegg serum_phospholipids NA 8.67E-05 no no no no up up mRNA surveillance pathway 18:2/16:0-PC+blood 0 -0.523529412 0 kegg serum_phospholipids NA 8.67E-05 no no no no up up mTOR signaling pathway 18:2/16:0-PC+blood 0 0 0.450769231 kegg serum_phospholipids NA 8.67E-05 no no no no up up Phagosome 18:2/16:0-PC+blood 0 0 -0.409230769 kegg serum_phospholipids NA 8.67E-05 no no no no up up Platelet activation 18:2/16:0-PC+blood 0 0 -0.43 kegg serum_phospholipids NA 8.67E-05 no no no no up up Prion disease 18:2/16:0-PC+blood 0 0 -0.426923077 kegg serum_phospholipids NA 8.67E-05 no no no no up up Protein processing in endoplasmic reticulum 18:2/16:0-PC+blood 0 0 0.423076923 kegg serum_phospholipids NA 8.67E-05 no no no no up up Rap1 signaling pathway 18:2/16:0-PC+blood 0 0 -0.426153846 kegg serum_phospholipids NA 8.67E-05 no no no no up up Renal cell carcinoma 18:2/16:0-PC+blood 0 -0.582352941 0.402307692 kegg serum_phospholipids NA 8.67E-05 no no no no up up Ruminococcus 18:2/16:0-PC+blood 0 -0.644607843 0 acetate-producing Genus serum_phospholipids 0.335 8.67E-05 no no no no up up TCA+stool 18:2/16:0-PC+blood -0.651995115 0 0 stool_bileacids serum_phospholipids 0.458 8.67E-05 no no no no up up Thyroid hormone signaling pathway 18:2/16:0-PC+blood 0 0 -0.655384615 kegg serum_phospholipids NA 8.67E-05 no no no no up up Type I diabetes mellitus 18:2/16:0-PC+blood 0 0 -0.504615385 kegg serum_phospholipids NA 8.67E-05 no no no no up up UDCA+stool 18:2/16:0-PC+blood 0 0 -0.523308271 stool_bileacids serum_phospholipids 0.266 8.67E-05 no no no no up up Vibrio cholerae infection 18:2/16:0-PC+blood 0 0 -0.430769231 kegg serum_phospholipids NA 8.67E-05 no no no no up up Viral carcinogenesis 18:2/16:0-PC+blood 0 0 -0.463846154 kegg serum_phospholipids NA 8.67E-05 no no no no up up Viral myocarditis 18:2/16:0-PC+blood 0 0 -0.590769231 kegg serum_phospholipids NA 8.67E-05 no no no no up up 12-ketoDCA+blood 18:2/18:1-PC+blood -0.493662555 0 0 serum_bileacids serum_phospholipids 0.517 2.30E-05 no no no dn up up 14:0/16:0-PC+blood 18:2/18:1-PC+blood -0.527819549 0 0 serum_phospholipids serum_phospholipids 0.0358 2.30E-05 no up no dn up up 14:0/18:2-PC+blood 18:2/18:1-PC+blood 0 0.504901961 0 serum_phospholipids serum_phospholipids 0.102 2.30E-05 no up no dn up up 16:0-LPE+blood 18:2/18:1-PC+blood -0.536842105 0 0 serum_phospholipids serum_phospholipids 0.0711 2.30E-05 up up no dn up up 16:0/16:0-PI+blood 18:2/18:1-PC+blood -0.560902256 0 0 serum_phospholipids serum_phospholipids 0.358 2.30E-05 no no no dn up up 16:0/16:1-PI+blood 18:2/18:1-PC+blood -0.479699248 0 0 serum_phospholipids serum_phospholipids 0.262 2.30E-05 no no no dn up up 16:0/18:0-PC+blood 18:2/18:1-PC+blood 0 0 0.734017094 serum_phospholipids serum_phospholipids 0.521 2.30E-05 no no no dn up up 16:0/18:0-PS+blood 18:2/18:1-PC+blood 0 0 -0.52 serum_phospholipids serum_phospholipids 0.377 2.30E-05 no no no dn up up 16:0/18:1-PE+blood 18:2/18:1-PC+blood 0 0 -0.452307692 serum_phospholipids serum_phospholipids 0.000107 2.30E-05 up up no dn up up 16:0/18:3-PC+blood 18:2/18:1-PC+blood 0 0.553921569 0 serum_phospholipids serum_phospholipids 0.00216 2.30E-05 no up up dn up up 16:0/20:3-PC+blood 18:2/18:1-PC+blood 0.613533835 0 0 serum_phospholipids serum_phospholipids 5.43E-06 2.30E-05 no up up dn up up 16:0/20:4-PE+blood 18:2/18:1-PC+blood 0 0 -0.47008547 serum_phospholipids serum_phospholipids 0.00139 2.30E-05 up up no dn up up 16:0/20:4-PI+blood 18:2/18:1-PC+blood -0.457142857 0 0 serum_phospholipids serum_phospholipids 0.558 2.30E-05 no no no dn up up 16:0/20:5-PC+blood 18:2/18:1-PC+blood -0.458646617 0 0 serum_phospholipids serum_phospholipids 0.628 2.30E-05 no no no dn up up 16:1/18:1-PG+blood 18:2/18:1-PC+blood 0 0 -0.548034188 serum_phospholipids serum_phospholipids 3.21E-05 2.30E-05 no up up dn up up 18:0-LPC+blood 18:2/18:1-PC+blood 0 0 0.534358974 serum_phospholipids serum_phospholipids 0.554 2.30E-05 no no no dn up up 18:0/18:0-PS+blood 18:2/18:1-PC+blood 0 0 -0.526153846 serum_phospholipids serum_phospholipids 0.00617 2.30E-05 no up no dn up up 18:0/20:2-PC+blood 18:2/18:1-PC+blood 0 0 0.460512821 serum_phospholipids serum_phospholipids 0.733 2.30E-05 no no no dn up up 18:0/22:6-PC+blood 18:2/18:1-PC+blood 0 -0.595588235 0 serum_phospholipids serum_phospholipids 0.0775 2.30E-05 no no up dn up up 18:0/22:6-PI+blood 18:2/18:1-PC+blood 0 -0.541666667 0 serum_phospholipids serum_phospholipids 0.425 2.30E-05 no no no dn up up 18:1-LPC+blood 18:2/18:1-PC+blood 0.676691729 0 0.435897436 serum_phospholipids serum_phospholipids 0.179 2.30E-05 no no no dn up up 18:1-LPE+blood 18:2/18:1-PC+blood 0 0 0.435897436 serum_phospholipids serum_phospholipids 0.117 2.30E-05 no no no dn up up 18:1/16:1-PE+blood 18:2/18:1-PC+blood 0 0 -0.452991453 serum_phospholipids serum_phospholipids 0.000184 2.30E-05 up up no dn up up 18:1/18:1-PC+blood 18:2/18:1-PC+blood 0.696240602 0 0 serum_phospholipids serum_phospholipids 1.34E-05 2.30E-05 no up up dn up up 18:1/18:1-PG+blood 18:2/18:1-PC+blood 0 0 -0.414017094 serum_phospholipids serum_phospholipids 0.00352 2.30E-05 no up up dn up up 18:1/18:1-PI+blood 18:2/18:1-PC+blood 0.523308271 0 0 serum_phospholipids serum_phospholipids 0.111 2.30E-05 dn no no dn up up 18:1/18:2-PG+blood 18:2/18:1-PC+blood 0.455639098 0 0 serum_phospholipids serum_phospholipids 5.58E-07 2.30E-05 no up up dn up up 18:1/18:2-PI+blood 18:2/18:1-PC+blood 0 0 0.587008547 serum_phospholipids serum_phospholipids 0.0164 2.30E-05 dn no up dn up up 18:1/20:3-PC+blood 18:2/18:1-PC+blood 0.615037594 0 0 serum_phospholipids serum_phospholipids 0.00872 2.30E-05 no up up dn up up 18:1/22:6-PE+blood 18:2/18:1-PC+blood 0 -0.583333333 0 serum_phospholipids serum_phospholipids 0.0047 2.30E-05 no up no dn up up 18:2-LPC+blood 18:2/18:1-PC+blood 0.693233083 0.683823529 0.636923077 serum_phospholipids serum_phospholipids 0.00743 2.30E-05 dn no up dn up up 18:2/16:0-PC+blood 18:2/18:1-PC+blood 0.559398496 0 0.464615385 serum_phospholipids serum_phospholipids 8.67E-05 2.30E-05 no up up dn up up 3-(3-Hydroxyphenyl)propanoic acid+stool 18:2/18:1-PC+blood 0 0 -0.505263158 stool_cometabolism serum_phospholipids 0.33 2.30E-05 no no no dn up up AMPK signaling pathway 18:2/18:1-PC+blood 0 0 0.47 kegg serum_phospholipids NA 2.30E-05 no no no dn up up Arginine and proline metabolism 18:2/18:1-PC+blood 0 0 -0.447692308 kegg serum_phospholipids NA 2.30E-05 no up no dn up up Longevity regulating pathway 18:2/18:1-PC+blood 0 0 0.407692308 kegg serum_phospholipids NA 2.30E-05 no no no dn up up Platinum drug resistance 18:2/18:1-PC+blood 0 0 0.431538462 kegg serum_phospholipids NA 2.30E-05 no no no dn up up Proteasome 18:2/18:1-PC+blood 0 0 -0.445384615 kegg serum_phospholipids NA 2.30E-05 no no no dn up up Ruminococcus 18:2/18:1-PC+blood 0 0 -0.483076923 acetate-producing Genus serum_phospholipids 0.335 2.30E-05 no no no dn up up Slackia 18:2/18:1-PC+blood 0 0 0.402933181 Genus serum_phospholipids 0.94 2.30E-05 no no no dn up up 14:0/16:0-PC+blood 18:2/18:2-PC+blood -0.485714286 0 0 serum_phospholipids serum_phospholipids 0.0358 1.98E-05 no up no dn up up 14:0/18:2-PC+blood 18:2/18:2-PC+blood 0 0.529411765 0 serum_phospholipids serum_phospholipids 0.102 1.98E-05 no up no dn up up 14:0/20:4-PC+blood 18:2/18:2-PC+blood 0 0.50245098 0 serum_phospholipids serum_phospholipids 0.486 1.98E-05 no no no dn up up 16:0-LPE+blood 18:2/18:2-PC+blood -0.505263158 0 0 serum_phospholipids serum_phospholipids 0.0711 1.98E-05 up up no dn up up 16:0/16:0-PI+blood 18:2/18:2-PC+blood -0.527819549 0 0 serum_phospholipids serum_phospholipids 0.358 1.98E-05 no no no dn up up 16:0/18:0-PC+blood 18:2/18:2-PC+blood 0 0 0.729230769 serum_phospholipids serum_phospholipids 0.521 1.98E-05 no no no dn up up 16:0/18:0-PS+blood 18:2/18:2-PC+blood 0 0 -0.532991453 serum_phospholipids serum_phospholipids 0.377 1.98E-05 no no no dn up up 16:0/18:1-PE+blood 18:2/18:2-PC+blood 0 0 -0.44 serum_phospholipids serum_phospholipids 0.000107 1.98E-05 up up no dn up up 16:0/18:3-PC+blood 18:2/18:2-PC+blood 0 0.588235294 0 serum_phospholipids serum_phospholipids 0.00216 1.98E-05 no up up dn up up 16:0/20:3-PC+blood 18:2/18:2-PC+blood 0.57443609 0 0 serum_phospholipids serum_phospholipids 5.43E-06 1.98E-05 no up up dn up up 16:0/20:4-PE+blood 18:2/18:2-PC+blood 0 0 -0.444786325 serum_phospholipids serum_phospholipids 0.00139 1.98E-05 up up no dn up up 16:1/18:1-PG+blood 18:2/18:2-PC+blood 0 0 -0.596581197 serum_phospholipids serum_phospholipids 3.21E-05 1.98E-05 no up up dn up up 18:0-LPC+blood 18:2/18:2-PC+blood 0 0 0.521367521 serum_phospholipids serum_phospholipids 0.554 1.98E-05 no no no dn up up 18:0/18:0-PS+blood 18:2/18:2-PC+blood 0 0 -0.528888889 serum_phospholipids serum_phospholipids 0.00617 1.98E-05 no up no dn up up 18:0/18:1-PG+blood 18:2/18:2-PC+blood 0 0 -0.403076923 serum_phospholipids serum_phospholipids 0.000842 1.98E-05 no up no dn up up 18:0/20:2-PC+blood 18:2/18:2-PC+blood 0 0 0.454358974 serum_phospholipids serum_phospholipids 0.733 1.98E-05 no no no dn up up 18:0/22:6-PC+blood 18:2/18:2-PC+blood 0 -0.585784314 0 serum_phospholipids serum_phospholipids 0.0775 1.98E-05 no no up dn up up 18:0/22:6-PI+blood 18:2/18:2-PC+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.425 1.98E-05 no no no dn up up 18:1-LPC+blood 18:2/18:2-PC+blood 0.621052632 0 0.431794872 serum_phospholipids serum_phospholipids 0.179 1.98E-05 no no no dn up up 18:1-LPE+blood 18:2/18:2-PC+blood 0 0 0.439316239 serum_phospholipids serum_phospholipids 0.117 1.98E-05 no no no dn up up 18:1/16:1-PE+blood 18:2/18:2-PC+blood 0 0 -0.441367521 serum_phospholipids serum_phospholipids 0.000184 1.98E-05 up up no dn up up 18:1/18:1-PC+blood 18:2/18:2-PC+blood 0.678195489 0 0 serum_phospholipids serum_phospholipids 1.34E-05 1.98E-05 no up up dn up up 18:1/18:1-PG+blood 18:2/18:2-PC+blood 0 0 -0.454358974 serum_phospholipids serum_phospholipids 0.00352 1.98E-05 no up up dn up up 18:1/18:1-PI+blood 18:2/18:2-PC+blood 0.494736842 0 0 serum_phospholipids serum_phospholipids 0.111 1.98E-05 dn no no dn up up 18:1/18:2-PI+blood 18:2/18:2-PC+blood 0 0 0.615042735 serum_phospholipids serum_phospholipids 0.0164 1.98E-05 dn no up dn up up 18:1/20:3-PC+blood 18:2/18:2-PC+blood 0.554887218 0 0 serum_phospholipids serum_phospholipids 0.00872 1.98E-05 no up up dn up up 18:1/22:6-PE+blood 18:2/18:2-PC+blood 0 -0.602941176 0 serum_phospholipids serum_phospholipids 0.0047 1.98E-05 no up no dn up up 18:2-LPC+blood 18:2/18:2-PC+blood 0.736842105 0.661764706 0.642393162 serum_phospholipids serum_phospholipids 0.00743 1.98E-05 dn no up dn up up 18:2/16:0-PC+blood 18:2/18:2-PC+blood 0.514285714 0 0.450940171 serum_phospholipids serum_phospholipids 8.67E-05 1.98E-05 no up up dn up up 18:2/18:1-PC+blood 18:2/18:2-PC+blood 0.97593985 0.995098039 0.993846154 serum_phospholipids serum_phospholipids 2.30E-05 1.98E-05 dn up up dn up up 3-(3-Hydroxyphenyl)propanoic acid+stool 18:2/18:2-PC+blood 0 0 -0.521804511 stool_cometabolism serum_phospholipids 0.33 1.98E-05 no no no dn up up AMPK signaling pathway 18:2/18:2-PC+blood 0 0 0.462307692 kegg serum_phospholipids NA 1.98E-05 no no no dn up up Arginine and proline metabolism 18:2/18:2-PC+blood 0 0 -0.463846154 kegg serum_phospholipids NA 1.98E-05 no up no dn up up Blautia 18:2/18:2-PC+blood 0 -0.50245098 0 acetate-producing Genus serum_phospholipids 1.36E-05 1.98E-05 up dn dn dn up up Collinsella 18:2/18:2-PC+blood -0.566265702 0 0 Genus serum_phospholipids 0.128 1.98E-05 no no no dn up up Estrogen signaling pathway 18:2/18:2-PC+blood 0 0 0.407692308 kegg serum_phospholipids NA 1.98E-05 no no no dn up up FoxO signaling pathway 18:2/18:2-PC+blood 0 0 0.408461538 kegg serum_phospholipids NA 1.98E-05 no no no dn up up Intestinal immune network for IgA production 18:2/18:2-PC+blood 0.526315789 0 0 kegg serum_phospholipids NA 1.98E-05 no no no dn up up Legionellosis 18:2/18:2-PC+blood 0 0.570588235 0 kegg serum_phospholipids NA 1.98E-05 no no no dn up up Longevity regulating pathway 18:2/18:2-PC+blood 0 0 0.401538462 kegg serum_phospholipids NA 1.98E-05 no no no dn up up Longevity regulating pathway - multiple species 18:2/18:2-PC+blood -0.48245614 0 0 kegg serum_phospholipids NA 1.98E-05 no no no dn up up Malaria 18:2/18:2-PC+blood 0 0.502941176 0 kegg serum_phospholipids NA 1.98E-05 no no no dn up up Mineral absorption 18:2/18:2-PC+blood 0 0.55 0 kegg serum_phospholipids NA 1.98E-05 no no no dn up up Necroptosis 18:2/18:2-PC+blood 0 0.538235294 0 kegg serum_phospholipids NA 1.98E-05 no no no dn up up Non-alcoholic fatty liver disease 18:2/18:2-PC+blood 0 0.597058824 0 kegg serum_phospholipids NA 1.98E-05 no no no dn up up "Parathyroid hormone synthesis, secretion and action" 18:2/18:2-PC+blood 0 0.511764706 0 kegg serum_phospholipids NA 1.98E-05 no no no dn up up Peroxisome 18:2/18:2-PC+blood -0.456140351 0 0 kegg serum_phospholipids NA 1.98E-05 no no no dn up up Phenylacetic acid+stool 18:2/18:2-PC+blood 0.615384615 0 0 stool_cometabolism serum_phospholipids 0.785 1.98E-05 no no no dn up up Platinum drug resistance 18:2/18:2-PC+blood 0 0 0.436923077 kegg serum_phospholipids NA 1.98E-05 no no no dn up up Proteasome 18:2/18:2-PC+blood 0 0 -0.458461538 kegg serum_phospholipids NA 1.98E-05 no no no dn up up Ruminococcus 18:2/18:2-PC+blood 0 0 -0.476923077 acetate-producing Genus serum_phospholipids 0.335 1.98E-05 no no no dn up up Slackia 18:2/18:2-PC+blood 0 0 0.427774931 Genus serum_phospholipids 0.94 1.98E-05 no no no dn up up Th1 and Th2 cell differentiation 18:2/18:2-PC+blood 0.542105263 0 0 kegg serum_phospholipids NA 1.98E-05 no no no dn up up Th17 cell differentiation 18:2/18:2-PC+blood 0.603508772 0 0 kegg serum_phospholipids NA 1.98E-05 no no no dn up up 11-HETE+blood 18:2/18:2-PS+blood 0 0.780064817 0 serum_ARA serum_phospholipids 0.464 0.00674 no no no up up no 12-HEPE+blood 18:2/18:2-PS+blood -0.507974499 0 0 serum_ARA serum_phospholipids 0.312 0.00674 no no no up up no 12-ketoDCA+blood 18:2/18:2-PS+blood 0 -0.484097716 0 serum_bileacids serum_phospholipids 0.517 0.00674 no no no up up no 14:0/18:0-PC+blood 18:2/18:2-PS+blood 0 0.676470588 0 serum_phospholipids serum_phospholipids 0.00289 0.00674 up up no up up no 15-HETE+blood 18:2/18:2-PS+blood -0.671231383 0 0 serum_ARA serum_phospholipids 0.819 0.00674 no no no up up no 16:0/16:1-PC+blood 18:2/18:2-PS+blood 0 0.683823529 0 serum_phospholipids serum_phospholipids 0.00283 0.00674 up up no up up no 16:0/16:1-PI+blood 18:2/18:2-PS+blood 0 0.602941176 0 serum_phospholipids serum_phospholipids 0.262 0.00674 no no no up up no 16:0/18:0-PS+blood 18:2/18:2-PS+blood 0.801503759 0 0.831794872 serum_phospholipids serum_phospholipids 0.377 0.00674 no no no up up no 16:0/18:1-PE+blood 18:2/18:2-PS+blood 0.62556391 0.742647059 0 serum_phospholipids serum_phospholipids 0.000107 0.00674 up up no up up no 16:0/18:2-PI+blood 18:2/18:2-PS+blood 0 0.529411765 0 serum_phospholipids serum_phospholipids 0.269 0.00674 no no no up up no 16:0/20:4-PE+blood 18:2/18:2-PS+blood 0.696240602 0.737745098 0 serum_phospholipids serum_phospholipids 0.00139 0.00674 up up no up up no 16:0/20:5-PG+blood 18:2/18:2-PS+blood 0 0 0.410598291 serum_phospholipids serum_phospholipids 0.00656 0.00674 no up no up up no 16:0/22:6-PC+blood 18:2/18:2-PS+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 4.53E-05 0.00674 no up up up up no 16:0/22:6-PE+blood 18:2/18:2-PS+blood 0.6 0.485294118 0.442051282 serum_phospholipids serum_phospholipids 0.000934 0.00674 up up no up up no 16:1/18:1-PG+blood 18:2/18:2-PS+blood 0 0.544117647 0.701196581 serum_phospholipids serum_phospholipids 3.21E-05 0.00674 no up up up up no 16:1/18:2-PG+blood 18:2/18:2-PS+blood 0 0.485294118 0.558290598 serum_phospholipids serum_phospholipids 1.40E-08 0.00674 no up up up up no 18:0-LPE+blood 18:2/18:2-PS+blood 0.586466165 0 0 serum_phospholipids serum_phospholipids 0.491 0.00674 no no no up up no 18:0/18:0-PS+blood 18:2/18:2-PS+blood 0.75037594 0 0.817435897 serum_phospholipids serum_phospholipids 0.00617 0.00674 no up no up up no 18:0/18:1-PG+blood 18:2/18:2-PS+blood 0 0 0.495384615 serum_phospholipids serum_phospholipids 0.000842 0.00674 no up no up up no 18:0/18:1-PI+blood 18:2/18:2-PS+blood 0 0.68872549 0 serum_phospholipids serum_phospholipids 0.599 0.00674 no no no up up no 18:0/18:2-PI+blood 18:2/18:2-PS+blood 0 0.507352941 0 serum_phospholipids serum_phospholipids 0.179 0.00674 no no no up up no 18:0/20:2-PC+blood 18:2/18:2-PS+blood 0 0 -0.408547009 serum_phospholipids serum_phospholipids 0.733 0.00674 no no no up up no 18:0/20:3-PC+blood 18:2/18:2-PS+blood 0 0.482843137 0 serum_phospholipids serum_phospholipids 0.0682 0.00674 no up no up up no 18:0/20:3-PI+blood 18:2/18:2-PS+blood 0 0.612745098 0 serum_phospholipids serum_phospholipids 0.377 0.00674 no no no up up no 18:0/20:4-PC+blood 18:2/18:2-PS+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.454 0.00674 no no no up up no 18:0/20:4-PI+blood 18:2/18:2-PS+blood 0 0 0.460512821 serum_phospholipids serum_phospholipids 0.167 0.00674 no no no up up no 18:0/20:5-PC+blood 18:2/18:2-PS+blood 0 -0.703431373 -0.538461538 serum_phospholipids serum_phospholipids 0.17 0.00674 no no no up up no 18:0/22:6-PA+blood 18:2/18:2-PS+blood 0 0 0.472136752 serum_phospholipids serum_phospholipids 0.22 0.00674 no no no up up no 18:0/22:6-PE+blood 18:2/18:2-PS+blood 0.44962406 0 0 serum_phospholipids serum_phospholipids 0.00022 0.00674 up up no up up no 18:1/16:0-PE+blood 18:2/18:2-PS+blood 0.560902256 0.647058824 0 serum_phospholipids serum_phospholipids 0.000182 0.00674 up up no up up no 18:1/16:0-PI+blood 18:2/18:2-PS+blood 0 0.588235294 0 serum_phospholipids serum_phospholipids 0.793 0.00674 no no no up up no 18:1/16:1-PE+blood 18:2/18:2-PS+blood 0.645112782 0.737745098 0 serum_phospholipids serum_phospholipids 0.000184 0.00674 up up no up up no 18:1/18:0-PE+blood 18:2/18:2-PS+blood 0.6 0.625 0 serum_phospholipids serum_phospholipids 1.39E-06 0.00674 up up no up up no 18:1/18:0-PI+blood 18:2/18:2-PS+blood 0.479699248 0.526960784 0 serum_phospholipids serum_phospholipids 0.0931 0.00674 no no up up up no 18:1/18:0-PS+blood 18:2/18:2-PS+blood 0 0 0.632820513 serum_phospholipids serum_phospholipids 0.193 0.00674 no no no up up no 18:1/18:1-PE+blood 18:2/18:2-PS+blood 0.658646617 0.62745098 0 serum_phospholipids serum_phospholipids 1.03E-05 0.00674 up up no up up no 18:1/18:1-PG+blood 18:2/18:2-PS+blood 0 0.517156863 0.573333333 serum_phospholipids serum_phospholipids 0.00352 0.00674 no up up up up no 18:1/18:2-PE+blood 18:2/18:2-PS+blood 0 0.642156863 0 serum_phospholipids serum_phospholipids 0.000293 0.00674 up up no up up no 18:1/18:2-PG+blood 18:2/18:2-PS+blood 0 0.529411765 0.511794872 serum_phospholipids serum_phospholipids 5.58E-07 0.00674 no up up up up no 18:1/18:2-PI+blood 18:2/18:2-PS+blood 0 0 -0.455042735 serum_phospholipids serum_phospholipids 0.0164 0.00674 dn no up up up no 18:1/20:3-PC+blood 18:2/18:2-PS+blood 0 0 -0.422222222 serum_phospholipids serum_phospholipids 0.00872 0.00674 no up up up up no 18:1/20:4-PC+blood 18:2/18:2-PS+blood 0 -0.610294118 0 serum_phospholipids serum_phospholipids 0.582 0.00674 no no no up up no 18:1/20:4-PE+blood 18:2/18:2-PS+blood 0.54887218 0 0 serum_phospholipids serum_phospholipids 0.0578 0.00674 up no no up up no 18:2/18:2-PC+blood 18:2/18:2-PS+blood 0 0 -0.403760684 serum_phospholipids serum_phospholipids 1.98E-05 0.00674 dn up up up up no 3-(3-Hydroxyphenyl)propanoic acid+stool 18:2/18:2-PS+blood 0 0 0.494736842 stool_cometabolism serum_phospholipids 0.33 0.00674 no no no up up no Adrenergic signaling in cardiomyocytes 18:2/18:2-PS+blood 0 0 0.424615385 kegg serum_phospholipids NA 0.00674 no no up up up no Calcium signaling pathway 18:2/18:2-PS+blood 0 0 0.454615385 kegg serum_phospholipids NA 0.00674 no up up up up no Carbon metabolism 18:2/18:2-PS+blood 0 0 -0.405384615 kegg serum_phospholipids NA 0.00674 no no no up up no Dopaminergic synapse 18:2/18:2-PS+blood 0 0 0.523076923 kegg serum_phospholipids NA 0.00674 no up no up up no Glycolysis / Gluconeogenesis 18:2/18:2-PS+blood 0 0 -0.43 kegg serum_phospholipids NA 0.00674 no no no up up no Long-term potentiation 18:2/18:2-PS+blood 0 0 0.502307692 kegg serum_phospholipids NA 0.00674 no no up up up no Neurotrophin signaling pathway 18:2/18:2-PS+blood 0 0 0.412307692 kegg serum_phospholipids NA 0.00674 no no no up up no Peroxisome 18:2/18:2-PS+blood 0 0 -0.45 kegg serum_phospholipids NA 0.00674 no no no up up no "12,13-EPOME+blood" 18:2/20:4-PC+blood 0 -0.623819213 0 serum_ARA serum_phospholipids 0.901 0.0145 no no no no no up 14:0/18:0-PC+blood 18:2/20:4-PC+blood 0 -0.524509804 0 serum_phospholipids serum_phospholipids 0.00289 0.0145 up up no no no up 14:0/20:4-PC+blood 18:2/20:4-PC+blood 0 0.693627451 0 serum_phospholipids serum_phospholipids 0.486 0.0145 no no no no no up 16:0/16:0-PI+blood 18:2/20:4-PC+blood 0 -0.512254902 0 serum_phospholipids serum_phospholipids 0.358 0.0145 no no no no no up 16:0/16:1-PC+blood 18:2/20:4-PC+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.00283 0.0145 up up no no no up 16:0/16:1-PI+blood 18:2/20:4-PC+blood 0 0 -0.417435897 serum_phospholipids serum_phospholipids 0.262 0.0145 no no no no no up 16:0/18:1-PE+blood 18:2/20:4-PC+blood 0 -0.769607843 0 serum_phospholipids serum_phospholipids 0.000107 0.0145 up up no no no up 16:0/18:2-PI+blood 18:2/20:4-PC+blood 0 -0.681372549 0 serum_phospholipids serum_phospholipids 0.269 0.0145 no no no no no up 16:0/20:4-PC+blood 18:2/20:4-PC+blood 0 0.531862745 0.442051282 serum_phospholipids serum_phospholipids 0.0262 0.0145 no up no no no up 16:0/20:4-PE+blood 18:2/20:4-PC+blood -0.509774436 -0.600490196 0 serum_phospholipids serum_phospholipids 0.00139 0.0145 up up no no no up 16:0/20:5-PC+blood 18:2/20:4-PC+blood 0.512781955 0 0 serum_phospholipids serum_phospholipids 0.628 0.0145 no no no no no up 16:0/20:5-PG+blood 18:2/20:4-PC+blood 0 0.669117647 0 serum_phospholipids serum_phospholipids 0.00656 0.0145 no up no no no up 16:0/22:0-PE+blood 18:2/20:4-PC+blood 0.454135338 0 0 serum_phospholipids serum_phospholipids 0.00839 0.0145 dn no up no no up 16:0/22:6-PC+blood 18:2/20:4-PC+blood 0.463157895 0 0 serum_phospholipids serum_phospholipids 4.53E-05 0.0145 no up up no no up 16:1/18:1-PG+blood 18:2/20:4-PC+blood 0 0 -0.462564103 serum_phospholipids serum_phospholipids 3.21E-05 0.0145 no up up no no up 16:1+blood 18:2/20:4-PC+blood 0 0 -0.476239316 yes serum_fattyacid serum_phospholipids 0.0186 0.0145 no no dn no no up 18:0/18:1-PE+blood 18:2/20:4-PC+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.00716 0.0145 up up no no no up 18:0/20:4-PC+blood 18:2/20:4-PC+blood 0.481203008 0.558823529 0.45982906 serum_phospholipids serum_phospholipids 0.454 0.0145 no no no no no up 18:0/20:5-PC+blood 18:2/20:4-PC+blood 0.717293233 0.546568627 0.448888889 serum_phospholipids serum_phospholipids 0.17 0.0145 no no no no no up 18:0/22:6-PC+blood 18:2/20:4-PC+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.0775 0.0145 no no up no no up 18:0/22:6-PI+blood 18:2/20:4-PC+blood 0 0 -0.456410256 serum_phospholipids serum_phospholipids 0.425 0.0145 no no no no no up 18:1-LPC+blood 18:2/20:4-PC+blood 0 0.610294118 0 serum_phospholipids serum_phospholipids 0.179 0.0145 no no no no no up 18:1-LPE+blood 18:2/20:4-PC+blood -0.538345865 0 0.403760684 serum_phospholipids serum_phospholipids 0.117 0.0145 no no no no no up 18:1/16:0-PE+blood 18:2/20:4-PC+blood 0 -0.742647059 0 serum_phospholipids serum_phospholipids 0.000182 0.0145 up up no no no up 18:1/16:0-PI+blood 18:2/20:4-PC+blood 0 -0.517156863 0 serum_phospholipids serum_phospholipids 0.793 0.0145 no no no no no up 18:1/16:1-PE+blood 18:2/20:4-PC+blood -0.47518797 -0.796568627 0 serum_phospholipids serum_phospholipids 0.000184 0.0145 up up no no no up 18:1/18:0-PE+blood 18:2/20:4-PC+blood -0.491729323 -0.580882353 0 serum_phospholipids serum_phospholipids 1.39E-06 0.0145 up up no no no up 18:1/18:1-PE+blood 18:2/20:4-PC+blood 0 -0.524509804 0 serum_phospholipids serum_phospholipids 1.03E-05 0.0145 up up no no no up 18:1/18:2-PE+blood 18:2/20:4-PC+blood 0 -0.615196078 0 serum_phospholipids serum_phospholipids 0.000293 0.0145 up up no no no up 18:1/18:2-PI+blood 18:2/20:4-PC+blood 0 0 0.418119658 serum_phospholipids serum_phospholipids 0.0164 0.0145 dn no up no no up 18:1/20:3-PC+blood 18:2/20:4-PC+blood 0 0 0.508376068 serum_phospholipids serum_phospholipids 0.00872 0.0145 no up up no no up 18:1/20:4-PC+blood 18:2/20:4-PC+blood 0.512781955 0.602941176 0.42017094 serum_phospholipids serum_phospholipids 0.582 0.0145 no no no no no up 18:1/20:4-PI+blood 18:2/20:4-PC+blood 0.520300752 0 0.487863248 serum_phospholipids serum_phospholipids 0.192 0.0145 no no no no no up 18:2-LPC+blood 18:2/20:4-PC+blood 0 0 0.403760684 serum_phospholipids serum_phospholipids 0.00743 0.0145 dn no up no no up 18:2/18:1-PC+blood 18:2/20:4-PC+blood 0 0 0.470769231 serum_phospholipids serum_phospholipids 2.30E-05 0.0145 dn up up no no up 18:2/18:2-PC+blood 18:2/20:4-PC+blood 0 0 0.524102564 serum_phospholipids serum_phospholipids 1.98E-05 0.0145 dn up up no no up 18:2/18:2-PS+blood 18:2/20:4-PC+blood -0.493233083 0 0 serum_phospholipids serum_phospholipids 0.00674 0.0145 up up no no no up 3-(3-Hydroxyphenyl)propanoic acid+stool 18:2/20:4-PC+blood 0 0 -0.455639098 stool_cometabolism serum_phospholipids 0.33 0.0145 no no no no no up Acetic acid+stool 18:2/20:4-PC+blood -0.565934066 0 0 yes stool_scfa serum_phospholipids 0.0656 0.0145 dn no no no no up Alistipes 18:2/20:4-PC+blood 0 0.521152765 0 Genus serum_phospholipids 0.0114 0.0145 no up no no no up Amoebiasis 18:2/20:4-PC+blood 0.480701754 0 0 kegg serum_phospholipids NA 0.0145 no no no no no up Arginine and proline metabolism 18:2/20:4-PC+blood 0 0 -0.401538462 kegg serum_phospholipids NA 0.0145 no up no no no up Autophagy - animal 18:2/20:4-PC+blood 0 0 0.409230769 kegg serum_phospholipids NA 0.0145 no no no no no up Bacteroides 18:2/20:4-PC+blood 0 0 -0.524102564 LPS-producing Genus serum_phospholipids 0.000267 0.0145 dn dn up no no up Bifidobacterium 18:2/20:4-PC+blood 0 0 -0.540336529 acetate-producing Genus serum_phospholipids 0.105 0.0145 no dn no no no up Butyricicoccus 18:2/20:4-PC+blood 0 -0.504841524 0 butyrate-producing Genus serum_phospholipids 0.852 0.0145 no no no no no up Cellular senescence 18:2/20:4-PC+blood 0.501754386 0 0 kegg serum_phospholipids NA 0.0145 no no no no no up Chemokine signaling pathway 18:2/20:4-PC+blood 0.466666667 0 0 kegg serum_phospholipids NA 0.0145 no no no no no up Clostridium 18:2/20:4-PC+blood 0 -0.492696923 0 Genus serum_phospholipids 0.925 0.0145 no no no no no up Collinsella 18:2/20:4-PC+blood 0 -0.763269747 0 Genus serum_phospholipids 0.128 0.0145 no no no no no up Cytosolic DNA-sensing pathway 18:2/20:4-PC+blood 0 0 -0.413846154 kegg serum_phospholipids NA 0.0145 no no no no no up Human papillomavirus infection 18:2/20:4-PC+blood 0.470175439 0 0 kegg serum_phospholipids NA 0.0145 no no no no no up iso-LCA+stool 18:2/20:4-PC+blood -0.580468225 0 0 stool_bileacids serum_phospholipids 0.72 0.0145 no no no no no up L-Tyrosine+stool 18:2/20:4-PC+blood 0 -0.609090909 0 stool_cometabolism serum_phospholipids 0.44 0.0145 no no no no no up Lachnospira 18:2/20:4-PC+blood 0 0 0.63287764 butyrate-producing Genus serum_phospholipids 0.279 0.0145 no no no no no up Natural killer cell mediated cytotoxicity 18:2/20:4-PC+blood 0.507017544 0 0 kegg serum_phospholipids NA 0.0145 no no no no no up Prevotella 18:2/20:4-PC+blood -0.49221169 0 0 acetate-producing Genus serum_phospholipids 0.287 0.0145 no no no no no up Protein processing in endoplasmic reticulum 18:2/20:4-PC+blood -0.521052632 0 0 kegg serum_phospholipids NA 0.0145 no no no no no up Ruminococcus 18:2/20:4-PC+blood 0 -0.719803937 0 Genus serum_phospholipids 0.0679 0.0145 no no dn no no up Viral carcinogenesis 18:2/20:4-PC+blood 0.556140351 0 0 kegg serum_phospholipids NA 0.0145 no no no no no up 12-ketoDCA+blood 18:2n6c+blood -0.453868406 0 0 serum_bileacids serum_fattyacid 0.517 0.15 no no no no no no 14:0/18:2-PC+blood 18:2n6c+blood 0 0 0.413333333 serum_phospholipids serum_fattyacid 0.102 0.15 no up no no no no 14:0+blood 18:2n6c+blood 0.502255639 0 0.461880342 yes serum_fattyacid serum_fattyacid 0.00572 0.15 up no dn no no no 16:0/16:0-PC+blood 18:2n6c+blood 0 0 0.409230769 serum_phospholipids serum_fattyacid 0.00079 0.15 no up up no no no 16:0/18:0-PC+blood 18:2n6c+blood 0 0 0.501538462 serum_phospholipids serum_fattyacid 0.521 0.15 no no no no no no 16:0/18:0-PS+blood 18:2n6c+blood 0 0 -0.437948718 serum_phospholipids serum_fattyacid 0.377 0.15 no no no no no no 16:0/20:5-PG+blood 18:2n6c+blood 0 0 -0.601367521 serum_phospholipids serum_fattyacid 0.00656 0.15 no up no no no no 16:0+blood 18:2n6c+blood 0.592481203 0.757352941 0.55965812 yes serum_fattyacid serum_fattyacid 0.00876 0.15 up no no no no no 16:1/16:1-PC+blood 18:2n6c+blood 0 0 0.405128205 serum_phospholipids serum_fattyacid 0.0177 0.15 no no up no no no 16:1/18:1-PG+blood 18:2n6c+blood 0 0 -0.411965812 serum_phospholipids serum_fattyacid 3.21E-05 0.15 no up up no no no 16:1/18:2-PG+blood 18:2n6c+blood 0 0.531862745 -0.406495726 serum_phospholipids serum_fattyacid 1.40E-08 0.15 no up up no no no 18:0/18:0-PS+blood 18:2n6c+blood 0 0 -0.50974359 serum_phospholipids serum_fattyacid 0.00617 0.15 no up no no no no 18:0/18:2-PC+blood 18:2n6c+blood 0 0.62745098 0 serum_phospholipids serum_fattyacid 1.74E-06 0.15 no up up no no no 18:0+blood 18:2n6c+blood 0.592481203 0.56372549 0 serum_fattyacid serum_fattyacid 0.344 0.15 no no no no no no 18:1/18:0-PC+blood 18:2n6c+blood 0 0.647058824 0 serum_phospholipids serum_fattyacid 1.83E-06 0.15 no up up no no no 18:1/18:0-PI+blood 18:2n6c+blood 0.445112782 0 0 serum_phospholipids serum_fattyacid 0.0931 0.15 no no up no no no 18:1/18:1-PG+blood 18:2n6c+blood 0 0 -0.627350427 serum_phospholipids serum_fattyacid 0.00352 0.15 no up up no no no 18:1/18:2-PG+blood 18:2n6c+blood 0 0 -0.42017094 serum_phospholipids serum_fattyacid 5.58E-07 0.15 no up up no no no 18:1+blood 18:2n6c+blood 0.529323308 0 0 yes serum_fattyacid serum_fattyacid 0.00202 0.15 up no dn no no no 18:2-LPC+blood 18:2n6c+blood 0.509774436 0 0 serum_phospholipids serum_fattyacid 0.00743 0.15 dn no up no no no 18:2/16:0-PC+blood 18:2n6c+blood 0 0.683823529 0 serum_phospholipids serum_fattyacid 8.67E-05 0.15 no up up no no no 18:2/18:1-PC+blood 18:2n6c+blood 0 0.615196078 0.59042735 serum_phospholipids serum_fattyacid 2.30E-05 0.15 dn up up no no no 18:2/18:2-PC+blood 18:2n6c+blood 0 0.598039216 0.570598291 serum_phospholipids serum_fattyacid 1.98E-05 0.15 dn up up no no no 3-(3-Hydroxyphenyl)propanoic acid+stool 18:2n6c+blood 0 0 -0.452631579 stool_cometabolism serum_fattyacid 0.33 0.15 no no no no no no AMPK signaling pathway 18:2n6c+blood 0 0 0.443076923 kegg serum_fattyacid NA 0.15 no no no no no no Biosynthesis of cofactors 18:2n6c+blood 0 0 0.416923077 kegg serum_fattyacid NA 0.15 no no no no no no Butyricicoccus 18:2n6c+blood -0.52757815 0 0 butyrate-producing Genus serum_fattyacid 0.852 0.15 no no no no no no Glutathione metabolism 18:2n6c+blood 0 0 0.400769231 kegg serum_fattyacid NA 0.15 no no no no no no "Glycine, serine and threonine metabolism" 18:2n6c+blood 0 -0.573529412 0.402307692 kegg serum_fattyacid NA 0.15 no up no no no no Leukocyte transendothelial migration 18:2n6c+blood 0.480701754 0 0 kegg serum_fattyacid NA 0.15 no no no no no no Longevity regulating pathway 18:2n6c+blood 0 0 0.417692308 kegg serum_fattyacid NA 0.15 no no no no no no Malaria 18:2n6c+blood 0 0 0.456923077 kegg serum_fattyacid NA 0.15 no no no no no no Methanobrevibacter 18:2n6c+blood 0 0 0.464827733 Genus serum_fattyacid 0.629 0.15 no no no no no no nutriCA+stool 18:2n6c+blood 0 0 -0.530827068 stool_bileacids serum_fattyacid 0.481 0.15 no no no no no no Pancreatic cancer 18:2n6c+blood 0.466666667 0 0 kegg serum_fattyacid NA 0.15 no no no no no no Phenylacetic acid+stool 18:2n6c+blood 0 0 0.481203008 stool_cometabolism serum_fattyacid 0.785 0.15 no no no no no no Porphyrin and chlorophyll metabolism 18:2n6c+blood 0 0 0.439230769 kegg serum_fattyacid NA 0.15 no no no no no no Roseburia 18:2n6c+blood 0 0 -0.411965812 butyrate-producing Genus serum_fattyacid 0.495 0.15 no no no no no no Ruminococcus 18:2n6c+blood 0 -0.531862745 0 acetate-producing Genus serum_fattyacid 0.335 0.15 no no no no no no Salivary secretion 18:2n6c+blood 0.480701754 0 0 kegg serum_fattyacid NA 0.15 no no no no no no Sphingolipid signaling pathway 18:2n6c+blood 0 0 -0.499230769 kegg serum_fattyacid NA 0.15 no no no no no no Tuberculosis 18:2n6c+blood 0.501754386 0 0 kegg serum_fattyacid NA 0.15 no no dn no no no UDCA+stool 18:2n6c+blood 0 0 -0.568421053 stool_bileacids serum_fattyacid 0.266 0.15 no no no no no no 14:0-LPC+blood 18:3-LPC+blood 0.472180451 0 0 serum_phospholipids serum_phospholipids 0.00689 0.147 up up no no no no 16:0-LPC+blood 18:3-LPC+blood 0 0.529411765 0 serum_phospholipids serum_phospholipids 0.00456 0.147 up up no no no no 16:0/16:1-PI+blood 18:3-LPC+blood 0 -0.482843137 0 serum_phospholipids serum_phospholipids 0.262 0.147 no no no no no no 16:0/18:0-PC+blood 18:3-LPC+blood -0.463157895 0 0 serum_phospholipids serum_phospholipids 0.521 0.147 no no no no no no 16:0/18:3-PC+blood 18:3-LPC+blood 0.457142857 0.522058824 0.450940171 serum_phospholipids serum_phospholipids 0.00216 0.147 no up up no no no 16:0/20:3-PC+blood 18:3-LPC+blood 0 -0.68627451 0 serum_phospholipids serum_phospholipids 5.43E-06 0.147 no up up no no no 16:0/20:4-PE+blood 18:3-LPC+blood 0 0 -0.414017094 serum_phospholipids serum_phospholipids 0.00139 0.147 up up no no no no 16:0/20:5-PG+blood 18:3-LPC+blood -0.512781955 0 0 serum_phospholipids serum_phospholipids 0.00656 0.147 no up no no no no 16:1/16:1-PC+blood 18:3-LPC+blood -0.463157895 0 0 serum_phospholipids serum_phospholipids 0.0177 0.147 no no up no no no 16:1/18:1-PG+blood 18:3-LPC+blood -0.496240602 -0.713235294 0 serum_phospholipids serum_phospholipids 3.21E-05 0.147 no up up no no no 18:0/18:0-PC+blood 18:3-LPC+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.426 0.147 no no no no no no 18:0/18:1-PC+blood 18:3-LPC+blood 0 -0.529411765 0 serum_phospholipids serum_phospholipids 0.393 0.147 no no no no no no 18:0/18:1-PI+blood 18:3-LPC+blood -0.601503759 0 0 serum_phospholipids serum_phospholipids 0.599 0.147 no no no no no no 18:0/20:2-PC+blood 18:3-LPC+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 0.733 0.147 no no no no no no 18:0/20:3-PC+blood 18:3-LPC+blood 0 -0.691176471 0 serum_phospholipids serum_phospholipids 0.0682 0.147 no up no no no no 18:0/20:3-PI+blood 18:3-LPC+blood 0 -0.776960784 0 serum_phospholipids serum_phospholipids 0.377 0.147 no no no no no no 18:0/20:4-PI+blood 18:3-LPC+blood -0.726315789 0 -0.439316239 serum_phospholipids serum_phospholipids 0.167 0.147 no no no no no no 18:1/18:0-PI+blood 18:3-LPC+blood 0 0 0.471452991 serum_phospholipids serum_phospholipids 0.0931 0.147 no no up no no no 18:1/18:1-PC+blood 18:3-LPC+blood 0 -0.68627451 0 serum_phospholipids serum_phospholipids 1.34E-05 0.147 no up up no no no 18:1/18:1-PG+blood 18:3-LPC+blood 0 -0.661764706 0 serum_phospholipids serum_phospholipids 0.00352 0.147 no up up no no no 18:1/18:1-PI+blood 18:3-LPC+blood -0.467669173 0 0 serum_phospholipids serum_phospholipids 0.111 0.147 dn no no no no no 18:1/20:3-PC+blood 18:3-LPC+blood 0 -0.647058824 0 serum_phospholipids serum_phospholipids 0.00872 0.147 no up up no no no 18:1+blood 18:3-LPC+blood 0 0 -0.476923077 yes serum_fattyacid serum_phospholipids 0.00202 0.147 up no dn no no no 18:2-LPC+blood 18:3-LPC+blood 0 0.642156863 0.477606838 serum_phospholipids serum_phospholipids 0.00743 0.147 dn no up no no no 18:2-LPE+blood 18:3-LPC+blood 0 0 0.424957265 serum_phospholipids serum_phospholipids 0.112 0.147 no no no no no no 18:2/18:1-PC+blood 18:3-LPC+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 2.30E-05 0.147 dn up up no no no 18:2/18:2-PC+blood 18:3-LPC+blood 0 0.514705882 0 serum_phospholipids serum_phospholipids 1.98E-05 0.147 dn up up no no no "12,13-EPOME+blood" 18:3/16:0-PE+blood 0 0.513586099 0 serum_ARA serum_phospholipids 0.901 0.00149 no no no up up no 14:0-LPC+blood 18:3/16:0-PE+blood 0 0 0.468717949 serum_phospholipids serum_phospholipids 0.00689 0.00149 up up no up up no 14:0/16:0-PC+blood 18:3/16:0-PE+blood 0 0 0.593162393 serum_phospholipids serum_phospholipids 0.0358 0.00149 no up no up up no 14:0/18:0-PC+blood 18:3/16:0-PE+blood 0 0.526960784 0.578803419 serum_phospholipids serum_phospholipids 0.00289 0.00149 up up no up up no 16:0-LPE+blood 18:3/16:0-PE+blood 0.553383459 0 0.589059829 serum_phospholipids serum_phospholipids 0.0711 0.00149 up up no up up no 16:0/14:0-PC+blood 18:3/16:0-PE+blood -0.454135338 0 0 serum_phospholipids serum_phospholipids 0.0206 0.00149 no up up up up no 16:0/16:0-PI+blood 18:3/16:0-PE+blood 0.533834586 0.485294118 0.632136752 serum_phospholipids serum_phospholipids 0.358 0.00149 no no no up up no 16:0/16:1-PC+blood 18:3/16:0-PE+blood 0 0.514705882 0.601367521 serum_phospholipids serum_phospholipids 0.00283 0.00149 up up no up up no 16:0/16:1-PI+blood 18:3/16:0-PE+blood 0.517293233 0 0.709401709 serum_phospholipids serum_phospholipids 0.262 0.00149 no no no up up no 16:0/18:0-PS+blood 18:3/16:0-PE+blood 0.69924812 0 0.409230769 serum_phospholipids serum_phospholipids 0.377 0.00149 no no no up up no 16:0/18:1-PC+blood 18:3/16:0-PE+blood -0.544360902 -0.593137255 0 serum_phospholipids serum_phospholipids 6.15E-07 0.00149 up up up up up no 16:0/18:1-PE+blood 18:3/16:0-PE+blood 0.796992481 0.612745098 0.725811966 serum_phospholipids serum_phospholipids 0.000107 0.00149 up up no up up no 16:0/18:2-PC+blood 18:3/16:0-PE+blood -0.694736842 0 0 serum_phospholipids serum_phospholipids 3.24E-06 0.00149 no up up up up no 16:0/18:2-PI+blood 18:3/16:0-PE+blood 0 0.703431373 0.626666667 serum_phospholipids serum_phospholipids 0.269 0.00149 no no no up up no 16:0/18:3-PC+blood 18:3/16:0-PE+blood 0 0 0.513162393 serum_phospholipids serum_phospholipids 0.00216 0.00149 no up up up up no 16:0/20:3-PC+blood 18:3/16:0-PE+blood -0.62406015 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.00149 no up up up up no 16:0/20:4-PC+blood 18:3/16:0-PE+blood -0.639097744 -0.727941176 0 serum_phospholipids serum_phospholipids 0.0262 0.00149 no up no up up no 16:0/20:4-PE+blood 18:3/16:0-PE+blood 0.596992481 0.651960784 0.543931624 serum_phospholipids serum_phospholipids 0.00139 0.00149 up up no up up no 16:0/20:4-PI+blood 18:3/16:0-PE+blood 0 0.536764706 0.657435897 serum_phospholipids serum_phospholipids 0.558 0.00149 no no no up up no 16:0/22:6-PC+blood 18:3/16:0-PE+blood -0.478195489 -0.595588235 0 serum_phospholipids serum_phospholipids 4.53E-05 0.00149 no up up up up no 16:0/22:6-PE+blood 18:3/16:0-PE+blood 0.67518797 0.590686275 0.61982906 serum_phospholipids serum_phospholipids 0.000934 0.00149 up up no up up no 16:1/16:0-PC+blood 18:3/16:0-PE+blood -0.530827068 -0.639705882 0 serum_phospholipids serum_phospholipids 0.0215 0.00149 no up up up up no 16:1/18:2-PG+blood 18:3/16:0-PE+blood -0.455639098 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.00149 no up up up up no 16:1+blood 18:3/16:0-PE+blood 0 0 0.472820513 yes serum_fattyacid serum_phospholipids 0.0186 0.00149 no no dn up up no 18:0/16:0-PC+blood 18:3/16:0-PE+blood -0.535338346 -0.647058824 0 serum_phospholipids serum_phospholipids 9.64E-07 0.00149 up up up up up no 18:0/18:0-PE+blood 18:3/16:0-PE+blood 0.67518797 0.651960784 0 serum_phospholipids serum_phospholipids 0.00896 0.00149 up up no up up no 18:0/18:0-PS+blood 18:3/16:0-PE+blood 0.532330827 0 0.424957265 serum_phospholipids serum_phospholipids 0.00617 0.00149 no up no up up no 18:0/18:1-PE+blood 18:3/16:0-PE+blood 0.69924812 0.710784314 0.460512821 serum_phospholipids serum_phospholipids 0.00716 0.00149 up up no up up no 18:0/18:1-PG+blood 18:3/16:0-PE+blood 0 0 0.460512821 serum_phospholipids serum_phospholipids 0.000842 0.00149 no up no up up no 18:0/18:2-PC+blood 18:3/16:0-PE+blood -0.586466165 0 0 serum_phospholipids serum_phospholipids 1.74E-06 0.00149 no up up up up no 18:0/20:2-PC+blood 18:3/16:0-PE+blood 0 0 -0.458461538 serum_phospholipids serum_phospholipids 0.733 0.00149 no no no up up no 18:0/20:4-PC+blood 18:3/16:0-PE+blood -0.598496241 -0.649509804 0 serum_phospholipids serum_phospholipids 0.454 0.00149 no no no up up no 18:0/20:5-PC+blood 18:3/16:0-PE+blood 0 -0.625 0 serum_phospholipids serum_phospholipids 0.17 0.00149 no no no up up no 18:0/22:6-PE+blood 18:3/16:0-PE+blood 0.613533835 0 0.426324786 serum_phospholipids serum_phospholipids 0.00022 0.00149 up up no up up no 18:1-LPC+blood 18:3/16:0-PE+blood 0 -0.522058824 -0.44957265 serum_phospholipids serum_phospholipids 0.179 0.00149 no no no up up no 18:1/16:0-PC+blood 18:3/16:0-PE+blood -0.714285714 0 0 serum_phospholipids serum_phospholipids 2.43E-05 0.00149 no up up up up no 18:1/16:0-PE+blood 18:3/16:0-PE+blood 0.836090226 0.678921569 0.745641026 serum_phospholipids serum_phospholipids 0.000182 0.00149 up up no up up no 18:1/16:0-PI+blood 18:3/16:0-PE+blood 0 0.522058824 0 serum_phospholipids serum_phospholipids 0.793 0.00149 no no no up up no 18:1/16:1-PE+blood 18:3/16:0-PE+blood 0.827067669 0.644607843 0.731282051 serum_phospholipids serum_phospholipids 0.000184 0.00149 up up no up up no 18:1/18:0-PC+blood 18:3/16:0-PE+blood -0.57443609 0 0 serum_phospholipids serum_phospholipids 1.83E-06 0.00149 no up up up up no 18:1/18:0-PE+blood 18:3/16:0-PE+blood 0.696240602 0.62745098 0.663589744 serum_phospholipids serum_phospholipids 1.39E-06 0.00149 up up no up up no 18:1/18:1-PC+blood 18:3/16:0-PE+blood -0.572932331 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.00149 no up up up up no 18:1/18:1-PE+blood 18:3/16:0-PE+blood 0.769924812 0.585784314 0.623247863 serum_phospholipids serum_phospholipids 1.03E-05 0.00149 up up no up up no 18:1/18:2-PE+blood 18:3/16:0-PE+blood 0.706766917 0.723039216 0.547350427 serum_phospholipids serum_phospholipids 0.000293 0.00149 up up no up up no 18:1/20:4-PC+blood 18:3/16:0-PE+blood -0.446616541 -0.62745098 0 serum_phospholipids serum_phospholipids 0.582 0.00149 no no no up up no 18:1/20:4-PE+blood 18:3/16:0-PE+blood 0.571428571 0.610294118 0.438632479 serum_phospholipids serum_phospholipids 0.0578 0.00149 up no no up up no 18:2-LPC+blood 18:3/16:0-PE+blood 0 0 -0.405811966 serum_phospholipids serum_phospholipids 0.00743 0.00149 dn no up up up no 18:2/16:0-PC+blood 18:3/16:0-PE+blood -0.535338346 0 0 serum_phospholipids serum_phospholipids 8.67E-05 0.00149 no up up up up no 18:2/18:2-PS+blood 18:3/16:0-PE+blood 0.618045113 0.593137255 0.408547009 serum_phospholipids serum_phospholipids 0.00674 0.00149 up up no up up no 18:2/20:4-PC+blood 18:3/16:0-PE+blood 0 -0.649509804 0 serum_phospholipids serum_phospholipids 0.0145 0.00149 no no up up up no 14:0/20:4-PC+blood 18:3/18:2-PC+blood 0.497744361 0.620098039 0.494017094 serum_phospholipids serum_phospholipids 0.486 0.0394 no no no no no up 16:0/18:0-PC+blood 18:3/18:2-PC+blood 0 0.536764706 0.677948718 serum_phospholipids serum_phospholipids 0.521 0.0394 no no no no no up 16:0/18:1-PE+blood 18:3/18:2-PC+blood 0 -0.541666667 -0.438632479 serum_phospholipids serum_phospholipids 0.000107 0.0394 up up no no no up 16:0/18:3-PC+blood 18:3/18:2-PC+blood 0.769924812 0.742647059 0 serum_phospholipids serum_phospholipids 0.00216 0.0394 no up up no no up 16:0/20:4-PE+blood 18:3/18:2-PC+blood 0 -0.526960784 -0.429059829 serum_phospholipids serum_phospholipids 0.00139 0.0394 up up no no no up 16:1/18:1-PG+blood 18:3/18:2-PC+blood 0 0 -0.478974359 serum_phospholipids serum_phospholipids 3.21E-05 0.0394 no up up no no up 16:1+blood 18:3/18:2-PC+blood 0 -0.647058824 0 yes serum_fattyacid serum_phospholipids 0.0186 0.0394 no no dn no no up 18:0-LPC+blood 18:3/18:2-PC+blood 0 0 0.446837607 serum_phospholipids serum_phospholipids 0.554 0.0394 no no no no no up 18:0/20:2-PC+blood 18:3/18:2-PC+blood 0 0 0.452307692 serum_phospholipids serum_phospholipids 0.733 0.0394 no no no no no up 18:0/20:3-PI+blood 18:3/18:2-PC+blood 0 -0.600490196 0 serum_phospholipids serum_phospholipids 0.377 0.0394 no no no no no up 18:1-LPC+blood 18:3/18:2-PC+blood 0 0 0.401709402 serum_phospholipids serum_phospholipids 0.179 0.0394 no no no no no up 18:1/16:1-PE+blood 18:3/18:2-PC+blood 0 -0.522058824 -0.450940171 serum_phospholipids serum_phospholipids 0.000184 0.0394 up up no no no up 18:1/22:6-PE+blood 18:3/18:2-PC+blood 0 -0.522058824 0 serum_phospholipids serum_phospholipids 0.0047 0.0394 no up no no no up 18:2-LPC+blood 18:3/18:2-PC+blood 0 0 0.558290598 serum_phospholipids serum_phospholipids 0.00743 0.0394 dn no up no no up 18:2/18:1-PC+blood 18:3/18:2-PC+blood 0 0.656862745 0.807863248 serum_phospholipids serum_phospholipids 2.30E-05 0.0394 dn up up no no up 18:2/18:2-PC+blood 18:3/18:2-PC+blood 0 0.683823529 0.796923077 serum_phospholipids serum_phospholipids 1.98E-05 0.0394 dn up up no no up 18:2/18:2-PS+blood 18:3/18:2-PC+blood 0 0 -0.405128205 serum_phospholipids serum_phospholipids 0.00674 0.0394 up up no no no up 18:2n6c+blood 18:3/18:2-PC+blood 0 0 0.43042735 serum_fattyacid serum_phospholipids 0.15 0.0394 no no no no no up 18:3-LPC+blood 18:3/18:2-PC+blood 0 0.566176471 0.47965812 serum_phospholipids serum_phospholipids 0.147 0.0394 no no no no no up 3-(3-Hydroxyphenyl)propanoic acid+stool 18:3/18:2-PC+blood 0 0 -0.50075188 stool_cometabolism serum_phospholipids 0.33 0.0394 no no no no no up Arginine and proline metabolism 18:3/18:2-PC+blood 0 0 -0.441538462 kegg serum_phospholipids NA 0.0394 no up no no no up B cell receptor signaling pathway 18:3/18:2-PC+blood 0 0 -0.467692308 kegg serum_phospholipids NA 0.0394 no no no no no up C-type lectin receptor signaling pathway 18:3/18:2-PC+blood 0 0 -0.406923077 kegg serum_phospholipids NA 0.0394 no no no no no up Epithelial cell signaling in Helicobacter pylori infection 18:3/18:2-PC+blood 0 0 -0.401538462 kegg serum_phospholipids NA 0.0394 no no no no no up FoxO signaling pathway 18:3/18:2-PC+blood 0 0 0.447692308 kegg serum_phospholipids NA 0.0394 no no no no no up Neurotrophin signaling pathway 18:3/18:2-PC+blood 0 0 -0.412307692 kegg serum_phospholipids NA 0.0394 no no no no no up Platinum drug resistance 18:3/18:2-PC+blood 0 0 0.492307692 kegg serum_phospholipids NA 0.0394 no no no no no up Primary immunodeficiency 18:3/18:2-PC+blood 0 0 0.516923077 kegg serum_phospholipids NA 0.0394 no no no no no up Proteasome 18:3/18:2-PC+blood 0 0 -0.437692308 kegg serum_phospholipids NA 0.0394 no no no no no up Toll-like receptor signaling pathway 18:3/18:2-PC+blood 0 0 -0.403076923 yes kegg serum_phospholipids NA 0.0394 no no no no no up 12-HEPE+blood 18:3n3+blood -0.462014901 0 0 serum_ARA serum_fattyacid 0.312 0.291 no no no no no no 12-ketoDCA+blood 18:3n3+blood -0.538834292 0 0 serum_bileacids serum_fattyacid 0.517 0.291 no no no no no no 13-HODE+blood 18:3n3+blood 0 0 0.571282051 serum_ARA serum_fattyacid 0.32 0.291 no no no no no no 14:0/18:0-PC+blood 18:3n3+blood 0 -0.661764706 0 serum_phospholipids serum_fattyacid 0.00289 0.291 up up no no no no 16:0/16:0-PI+blood 18:3n3+blood 0 -0.522058824 0 serum_phospholipids serum_fattyacid 0.358 0.291 no no no no no no 16:0/16:1-PC+blood 18:3n3+blood 0 -0.642156863 0 serum_phospholipids serum_fattyacid 0.00283 0.291 up up no no no no 16:0/16:1-PI+blood 18:3n3+blood 0 -0.696078431 0 serum_phospholipids serum_fattyacid 0.262 0.291 no no no no no no 16:0/18:3-PC+blood 18:3n3+blood 0.505263158 0 0 serum_phospholipids serum_fattyacid 0.00216 0.291 no up up no no no 16:0/20:5-PG+blood 18:3n3+blood 0 0 -0.427692308 serum_phospholipids serum_fattyacid 0.00656 0.291 no up no no no no 16:0/22:6-PC+blood 18:3n3+blood 0.490225564 0 0 serum_phospholipids serum_fattyacid 4.53E-05 0.291 no up up no no no 16:0+blood 18:3n3+blood 0.481203008 0 0 yes serum_fattyacid serum_fattyacid 0.00876 0.291 up no no no no no 16:1/16:1-PC+blood 18:3n3+blood 0 0.512254902 0 serum_phospholipids serum_fattyacid 0.0177 0.291 no no up no no no 16:1/18:1-PG+blood 18:3n3+blood 0 0 -0.497435897 serum_phospholipids serum_fattyacid 3.21E-05 0.291 no up up no no no 16:1+blood 18:3n3+blood 0.685714286 0 0 yes serum_fattyacid serum_fattyacid 0.0186 0.291 no no dn no no no 18:0-LPC+blood 18:3n3+blood 0 -0.482843137 0 serum_phospholipids serum_fattyacid 0.554 0.291 no no no no no no 18:0/18:0-PC+blood 18:3n3+blood 0 -0.522058824 0 serum_phospholipids serum_fattyacid 0.426 0.291 no no no no no no 18:0/18:0-PS+blood 18:3n3+blood 0.461654135 0 0 serum_phospholipids serum_fattyacid 0.00617 0.291 no up no no no no 18:0/18:1-PC+blood 18:3n3+blood 0 -0.56127451 0 serum_phospholipids serum_fattyacid 0.393 0.291 no no no no no no 18:0/20:2-PC+blood 18:3n3+blood 0 -0.715686275 0 serum_phospholipids serum_fattyacid 0.733 0.291 no no no no no no 18:0/20:3-PC+blood 18:3n3+blood 0 -0.774509804 0 serum_phospholipids serum_fattyacid 0.0682 0.291 no up no no no no 18:0/20:3-PI+blood 18:3n3+blood 0 -0.585784314 0 serum_phospholipids serum_fattyacid 0.377 0.291 no no no no no no 18:0/22:6-PI+blood 18:3n3+blood 0.527819549 0 0 serum_phospholipids serum_fattyacid 0.425 0.291 no no no no no no 18:1/18:0-PS+blood 18:3n3+blood 0.536842105 0 0 serum_phospholipids serum_fattyacid 0.193 0.291 no no no no no no 18:1/18:1-PC+blood 18:3n3+blood 0 -0.580882353 0 serum_phospholipids serum_fattyacid 1.34E-05 0.291 no up up no no no 18:1/18:1-PG+blood 18:3n3+blood 0 -0.578431373 -0.569230769 serum_phospholipids serum_fattyacid 0.00352 0.291 no up up no no no 18:1/20:3-PC+blood 18:3n3+blood 0 -0.647058824 0 serum_phospholipids serum_fattyacid 0.00872 0.291 no up up no no no 18:1/20:4-PE+blood 18:3n3+blood 0.497744361 0 0 serum_phospholipids serum_fattyacid 0.0578 0.291 up no no no no no 18:1+blood 18:3n3+blood 0.508270677 0 0 yes serum_fattyacid serum_fattyacid 0.00202 0.291 up no dn no no no 18:2/16:0-PC+blood 18:3n3+blood 0 0.524509804 0.472136752 serum_phospholipids serum_fattyacid 8.67E-05 0.291 no up up no no no 18:2/18:2-PC+blood 18:3n3+blood 0 0 0.408547009 serum_phospholipids serum_fattyacid 1.98E-05 0.291 dn up up no no no 18:2n6c+blood 18:3n3+blood 0.503759398 0 0.58017094 serum_fattyacid serum_fattyacid 0.15 0.291 no no no no no no 18:3-LPC+blood 18:3n3+blood 0 0.634803922 0 serum_phospholipids serum_fattyacid 0.147 0.291 no no no no no no 18:3/18:2-PC+blood 18:3n3+blood 0 0 0.42974359 serum_phospholipids serum_fattyacid 0.0394 0.291 no no up no no no Adipocytokine signaling pathway 18:3n3+blood -0.610526316 0 0 kegg serum_fattyacid NA 0.291 no no no no no no AGE-RAGE signaling pathway in diabetic complications 18:3n3+blood 0.514035088 0 0 kegg serum_fattyacid NA 0.291 no no no no no no AMPK signaling pathway 18:3n3+blood -0.649122807 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Axon guidance 18:3n3+blood 0 -0.588235294 0 kegg serum_fattyacid NA 0.291 no up up no no no Calcium signaling pathway 18:3n3+blood 0 -0.582352941 0 kegg serum_fattyacid NA 0.291 no up up no no no CDCA+stool 18:3n3+blood 0.576923077 0 0 stool_bileacids serum_fattyacid 0.663 0.291 no no no no no no cGMP-PKG signaling pathway 18:3n3+blood 0.524561404 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Coronavirus disease - COVID-19 18:3n3+blood -0.554385965 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Fc gamma R-mediated phagocytosis 18:3n3+blood 0.707017544 0 0 kegg serum_fattyacid NA 0.291 no no no no no no FoxO signaling pathway 18:3n3+blood 0 0 0.448461538 kegg serum_fattyacid NA 0.291 no no no no no no HCA+stool 18:3n3+blood 0.708791209 0 0 stool_bileacids serum_fattyacid 0.155 0.291 no no no no no no Kaposi sarcoma-associated herpesvirus infection 18:3n3+blood -0.563157895 0 0 kegg serum_fattyacid NA 0.291 no no dn no no no Lipid and atherosclerosis 18:3n3+blood 0.69122807 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Longevity regulating pathway 18:3n3+blood -0.49122807 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Methanobrevibacter 18:3n3+blood 0 0 0.612331615 Genus serum_fattyacid 0.629 0.291 no no no no no no Mineral absorption 18:3n3+blood -0.603508772 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Mitophagy - animal 18:3n3+blood -0.685964912 0 0 kegg serum_fattyacid NA 0.291 no no no no no no mTOR signaling pathway 18:3n3+blood -0.545614035 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Necroptosis 18:3n3+blood -0.464912281 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Neutrophil extracellular trap formation 18:3n3+blood 0.487719298 0 0 kegg serum_fattyacid NA 0.291 no no no no no no NOD-like receptor signaling pathway 18:3n3+blood 0.507017544 0 0.403846154 kegg serum_fattyacid NA 0.291 no no no no no no nutriCA+stool 18:3n3+blood 0.653846154 0 -0.517293233 stool_bileacids serum_fattyacid 0.481 0.291 no no no no no no Olfactory transduction 18:3n3+blood 0.645614035 0 0 kegg serum_fattyacid NA 0.291 no no no no no no "Parathyroid hormone synthesis, secretion and action" 18:3n3+blood -0.498245614 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Parkinson disease 18:3n3+blood -0.628070175 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Pathways of neurodegeneration - multiple diseases 18:3n3+blood -0.638596491 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Peroxisome 18:3n3+blood 0.503508772 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Pertussis 18:3n3+blood 0.694736842 0 0 kegg serum_fattyacid NA 0.291 no no dn no no no Purine metabolism 18:3n3+blood -0.501754386 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Ribosome 18:3n3+blood -0.554385965 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Ruminococcus 18:3n3+blood 0 -0.504901961 0 acetate-producing Genus serum_fattyacid 0.335 0.291 no no no no no no Salmonella infection 18:3n3+blood 0.605263158 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Shigellosis 18:3n3+blood -0.596491228 0 0 kegg serum_fattyacid NA 0.291 no no no no no no Tuberculosis 18:3n3+blood 0.570175439 0 0 kegg serum_fattyacid NA 0.291 no no dn no no no Ubiquitin mediated proteolysis 18:3n3+blood -0.663157895 0 0 kegg serum_fattyacid NA 0.291 no no no no no no UDCA+stool 18:3n3+blood 0.56043956 0 -0.464661654 stool_bileacids serum_fattyacid 0.266 0.291 no no no no no no Yersinia infection 18:3n3+blood 0.521052632 0 0 kegg serum_fattyacid NA 0.291 no no no no no no 13-HODE+blood 18:3n6+blood 0 -0.737745098 0 serum_ARA serum_fattyacid 0.32 0.0463 no no no up no dn 14:0-LPC+blood 18:3n6+blood 0 0 0.406495726 serum_phospholipids serum_fattyacid 0.00689 0.0463 up up no up no dn 14:0/18:0-PC+blood 18:3n6+blood 0.521804511 0 0 serum_phospholipids serum_fattyacid 0.00289 0.0463 up up no up no dn 14:0/20:4-PC+blood 18:3n6+blood 0.533834586 0 0.406495726 serum_phospholipids serum_fattyacid 0.486 0.0463 no no no up no dn 14:0+blood 18:3n6+blood 0.446616541 0 0 yes serum_fattyacid serum_fattyacid 0.00572 0.0463 up no dn up no dn 16:0/16:0-PI+blood 18:3n6+blood 0 0 0.405811966 serum_phospholipids serum_fattyacid 0.358 0.0463 no no no up no dn 16:0/16:1-PC+blood 18:3n6+blood 0.445112782 0 0 serum_phospholipids serum_fattyacid 0.00283 0.0463 up up no up no dn 16:0/16:1-PI+blood 18:3n6+blood 0.628571429 0 0.59042735 serum_phospholipids serum_fattyacid 0.262 0.0463 no no no up no dn 16:0/18:1-PC+blood 18:3n6+blood -0.472180451 0 0 serum_phospholipids serum_fattyacid 6.15E-07 0.0463 up up up up no dn 16:0/18:2-PC+blood 18:3n6+blood -0.526315789 -0.566176471 0 serum_phospholipids serum_fattyacid 3.24E-06 0.0463 no up up up no dn 16:0/18:2-PI+blood 18:3n6+blood 0 0 0.500854701 serum_phospholipids serum_fattyacid 0.269 0.0463 no no no up no dn 16:0/18:3-PC+blood 18:3n6+blood 0 0 0.503589744 serum_phospholipids serum_fattyacid 0.00216 0.0463 no up up up no dn 16:0/20:4-PI+blood 18:3n6+blood 0.598496241 0 0.542564103 serum_phospholipids serum_fattyacid 0.558 0.0463 no no no up no dn 16:0/20:5-PG+blood 18:3n6+blood 0 0.590686275 0 serum_phospholipids serum_fattyacid 0.00656 0.0463 no up no up no dn 16:1/16:0-PC+blood 18:3n6+blood -0.466165414 0 0 serum_phospholipids serum_fattyacid 0.0215 0.0463 no up up up no dn 18:0-LPC+blood 18:3n6+blood 0 0.625 0 serum_phospholipids serum_fattyacid 0.554 0.0463 no no no up no dn 18:0/16:0-PC+blood 18:3n6+blood -0.488721805 -0.490196078 0 serum_phospholipids serum_fattyacid 9.64E-07 0.0463 up up up up no dn 18:0/18:1-PG+blood 18:3n6+blood 0 0.732843137 0 serum_phospholipids serum_fattyacid 0.000842 0.0463 no up no up no dn 18:0/18:2-PC+blood 18:3n6+blood -0.526315789 0 0 serum_phospholipids serum_fattyacid 1.74E-06 0.0463 no up up up no dn 18:1-LPC+blood 18:3n6+blood -0.502255639 0 0 serum_phospholipids serum_fattyacid 0.179 0.0463 no no no up no dn 18:1/16:0-PC+blood 18:3n6+blood -0.47518797 -0.578431373 0 serum_phospholipids serum_fattyacid 2.43E-05 0.0463 no up up up no dn 18:1/18:0-PC+blood 18:3n6+blood -0.470676692 0 0 serum_phospholipids serum_fattyacid 1.83E-06 0.0463 no up up up no dn 18:2/16:0-PC+blood 18:3n6+blood -0.615037594 0 0 serum_phospholipids serum_fattyacid 8.67E-05 0.0463 no up up up no dn 18:3-LPC+blood 18:3n6+blood 0 0 0.433162393 serum_phospholipids serum_fattyacid 0.147 0.0463 no no no up no dn 18:3/16:0-PE+blood 18:3n6+blood 0 0 0.514529915 serum_phospholipids serum_fattyacid 0.00149 0.0463 up up no up no dn Acetic acid+stool 18:3n6+blood 0 0 0.455639098 yes stool_scfa serum_fattyacid 0.0656 0.0463 dn no no up no dn Aldosterone synthesis and secretion 18:3n6+blood 0 0.517647059 0 kegg serum_fattyacid NA 0.0463 no up up up no dn Amphetamine addiction 18:3n6+blood 0 0.579411765 0 kegg serum_fattyacid NA 0.0463 no no no up no dn CA+stool 18:3n6+blood 0 0 0.590977444 stool_bileacids serum_fattyacid 0.827 0.0463 no no no up no dn CDCA+stool 18:3n6+blood 0 0 0.606015038 stool_bileacids serum_fattyacid 0.663 0.0463 no no no up no dn Central carbon metabolism in cancer 18:3n6+blood 0 0.608823529 0 kegg serum_fattyacid NA 0.0463 no no no up no dn Cocaine addiction 18:3n6+blood 0 0 0.423076923 kegg serum_fattyacid NA 0.0463 no no no up no dn Colorectal cancer 18:3n6+blood 0 0.547058824 0 kegg serum_fattyacid NA 0.0463 no no no up no dn Endocrine resistance 18:3n6+blood 0 0.588235294 0 kegg serum_fattyacid NA 0.0463 no no no up no dn Fc epsilon RI signaling pathway 18:3n6+blood -0.521052632 0 0 kegg serum_fattyacid NA 0.0463 no no no up no dn FoxO signaling pathway 18:3n6+blood 0 0 -0.416153846 kegg serum_fattyacid NA 0.0463 no no no up no dn Glucagon signaling pathway 18:3n6+blood 0 0.511764706 0 kegg serum_fattyacid NA 0.0463 no no no up no dn "Glycine, serine and threonine metabolism" 18:3n6+blood 0.459649123 0 0 kegg serum_fattyacid NA 0.0463 no up no up no dn Glycolysis / Gluconeogenesis 18:3n6+blood 0.484210526 0 -0.433076923 kegg serum_fattyacid NA 0.0463 no no no up no dn GnRH signaling pathway 18:3n6+blood 0 0.552941176 0 kegg serum_fattyacid NA 0.0463 no no no up no dn Hepatitis C 18:3n6+blood -0.471929825 0 0 kegg serum_fattyacid NA 0.0463 no no no up no dn Inflammatory mediator regulation of TRP channels 18:3n6+blood 0 0.6 0 kegg serum_fattyacid NA 0.0463 no no no up no dn iso-LCA+stool 18:3n6+blood 0 0 -0.529323308 stool_bileacids serum_fattyacid 0.72 0.0463 no no no up no dn L-Phenylalanine+stool 18:3n6+blood -0.582417582 -0.681818182 -0.633082707 stool_cometabolism serum_fattyacid 0.398 0.0463 no no no up no dn L-Tryptophan+stool 18:3n6+blood 0 -0.818181818 -0.503759398 stool_cometabolism serum_fattyacid 0.557 0.0463 no no no up no dn L-Tyrosine+stool 18:3n6+blood -0.642857143 0 -0.583458647 stool_cometabolism serum_fattyacid 0.44 0.0463 no no no up no dn Legionellosis 18:3n6+blood 0 0 -0.496923077 kegg serum_fattyacid NA 0.0463 no no no up no dn Leishmaniasis 18:3n6+blood 0 0 -0.485384615 kegg serum_fattyacid NA 0.0463 no no no up no dn Longevity regulating pathway - multiple species 18:3n6+blood 0 0 -0.473846154 kegg serum_fattyacid NA 0.0463 no no no up no dn Pathogenic Escherichia coli infection 18:3n6+blood 0 -0.567647059 0 kegg serum_fattyacid NA 0.0463 no no no up no dn Phenylacetic acid+stool 18:3n6+blood 0 0 -0.655639098 stool_cometabolism serum_fattyacid 0.785 0.0463 no no no up no dn Phosphatidylinositol signaling system 18:3n6+blood 0 0.535294118 0 kegg serum_fattyacid NA 0.0463 no no no up no dn Prevotella 18:3n6+blood 0 0.495236598 0 acetate-producing Genus serum_fattyacid 0.287 0.0463 no no no up no dn Salmonella infection 18:3n6+blood 0 -0.632352941 0 kegg serum_fattyacid NA 0.0463 no no no up no dn Sphingolipid signaling pathway 18:3n6+blood -0.501754386 0 0 kegg serum_fattyacid NA 0.0463 no no no up no dn TCA+stool 18:3n6+blood 0.629986841 0 0 stool_bileacids serum_fattyacid 0.458 0.0463 no no no up no dn UDCA+stool 18:3n6+blood 0 0 0.518796992 stool_bileacids serum_fattyacid 0.266 0.0463 no no no up no dn Viral carcinogenesis 18:3n6+blood 0 0 0.413076923 kegg serum_fattyacid NA 0.0463 no no no up no dn 14:0/18:2-PC+blood 2-hydroxyhippuric acid+urine -0.558823529 0 0 serum_phospholipids urine_cometabolism 0.102 0.215 no up no no no no 16:0/16:0-PC+blood 2-hydroxyhippuric acid+urine -0.816176471 0 0 serum_phospholipids urine_cometabolism 0.00079 0.215 no up up no no no 16:0/18:0-PC+blood 2-hydroxyhippuric acid+urine -0.671568627 0 0 serum_phospholipids urine_cometabolism 0.521 0.215 no no no no no no 16:0/18:1-PC+blood 2-hydroxyhippuric acid+urine -0.571078431 0 0 serum_phospholipids urine_cometabolism 6.15E-07 0.215 up up up no no no 16:0/18:2-PC+blood 2-hydroxyhippuric acid+urine -0.629901961 0 0 serum_phospholipids urine_cometabolism 3.24E-06 0.215 no up up no no no 16:0/18:3-PC+blood 2-hydroxyhippuric acid+urine -0.546568627 0 0 serum_phospholipids urine_cometabolism 0.00216 0.215 no up up no no no 16:0/20:3-PC+blood 2-hydroxyhippuric acid+urine -0.671568627 0 0 serum_phospholipids urine_cometabolism 5.43E-06 0.215 no up up no no no 16:0/22:6-PC+blood 2-hydroxyhippuric acid+urine -0.723039216 0 0 serum_phospholipids urine_cometabolism 4.53E-05 0.215 no up up no no no 16:1/16:0-PC+blood 2-hydroxyhippuric acid+urine -0.808823529 0 0 serum_phospholipids urine_cometabolism 0.0215 0.215 no up up no no no 16:1/16:1-PC+blood 2-hydroxyhippuric acid+urine -0.784313725 0 0 serum_phospholipids urine_cometabolism 0.0177 0.215 no no up no no no 16:1/18:2-PG+blood 2-hydroxyhippuric acid+urine -0.571078431 0 0 serum_phospholipids urine_cometabolism 1.40E-08 0.215 no up up no no no 18:0-LPC+blood 2-hydroxyhippuric acid+urine 0 0 -0.461038961 serum_phospholipids urine_cometabolism 0.554 0.215 no no no no no no 18:0/16:0-PC+blood 2-hydroxyhippuric acid+urine -0.588235294 0 0 serum_phospholipids urine_cometabolism 9.64E-07 0.215 up up up no no no 18:0/18:2-PC+blood 2-hydroxyhippuric acid+urine -0.730392157 0 0 serum_phospholipids urine_cometabolism 1.74E-06 0.215 no up up no no no 18:0/22:6-PA+blood 2-hydroxyhippuric acid+urine -0.669117647 0 0 serum_phospholipids urine_cometabolism 0.22 0.215 no no no no no no 18:0/22:6-PC+blood 2-hydroxyhippuric acid+urine -0.526960784 0 0 serum_phospholipids urine_cometabolism 0.0775 0.215 no no up no no no 18:1-LPE+blood 2-hydroxyhippuric acid+urine 0.56372549 0 0 serum_phospholipids urine_cometabolism 0.117 0.215 no no no no no no 18:1/16:0-PC+blood 2-hydroxyhippuric acid+urine -0.588235294 0 0 serum_phospholipids urine_cometabolism 2.43E-05 0.215 no up up no no no 18:1/18:0-PC+blood 2-hydroxyhippuric acid+urine -0.742647059 0 0 serum_phospholipids urine_cometabolism 1.83E-06 0.215 no up up no no no 18:1/18:1-PC+blood 2-hydroxyhippuric acid+urine -0.509803922 0 0 serum_phospholipids urine_cometabolism 1.34E-05 0.215 no up up no no no 18:1/20:3-PC+blood 2-hydroxyhippuric acid+urine -0.504901961 0 0 serum_phospholipids urine_cometabolism 0.00872 0.215 no up up no no no 18:2-LPA+blood 2-hydroxyhippuric acid+urine -0.487745098 0 0 serum_phospholipids urine_cometabolism 0.00684 0.215 dn no up no no no 18:2/16:0-PC+blood 2-hydroxyhippuric acid+urine -0.693627451 0 -0.601298701 serum_phospholipids urine_cometabolism 8.67E-05 0.215 no up up no no no 18:2/18:2-PC+blood 2-hydroxyhippuric acid+urine 0 -0.565934066 0 serum_phospholipids urine_cometabolism 1.98E-05 0.215 dn up up no no no 18:3n3+blood 2-hydroxyhippuric acid+urine -0.514705882 0 -0.462337662 serum_fattyacid urine_cometabolism 0.291 0.215 no no no no no no 20:0/20:5-PC+blood 2-hydroxyhippuric acid+urine -0.495098039 0 0 serum_phospholipids urine_cometabolism 0.882 0.215 no no no no no no 20:1-LPA+blood 2-hydroxyhippuric acid+urine -0.495098039 0 0 serum_phospholipids urine_cometabolism 0.0187 0.215 dn dn no no no no 20:3/18:0-PC+blood 2-hydroxyhippuric acid+urine -0.732843137 0 0 serum_phospholipids urine_cometabolism 0.296 0.215 no no no no no no 20:5/18:0-PC+blood 2-hydroxyhippuric acid+urine -0.762254902 0 0 serum_phospholipids urine_cometabolism 3.97E-06 0.215 no up up no no no Adipocytokine signaling pathway 2-hydroxyhippuric acid+urine 0.49122807 0 -0.442307692 kegg urine_cometabolism NA 0.215 no no no no no no Butyric acid+stool 2-hydroxyhippuric acid+urine 0 0 0.475748194 yes stool_scfa urine_cometabolism 0.102 0.215 dn no no no no no CDCA+blood 2-hydroxyhippuric acid+urine 0.517156863 0 0 serum_bileacids urine_cometabolism 0.506 0.215 no no no no no no Clostridium 2-hydroxyhippuric acid+urine -0.550582965 0 0 Genus urine_cometabolism 0.925 0.215 no no no no no no Cysteine+blood 2-hydroxyhippuric acid+urine -0.495098039 0 0 yes serum_aminoacids urine_cometabolism 1.81E-07 0.215 dn up up no no no d18:0-24:1-SM+blood 2-hydroxyhippuric acid+urine 0.585784314 0 0 serum_phospholipids urine_cometabolism 0.0609 0.215 no dn dn no no no d18:1-18:0-SM+blood 2-hydroxyhippuric acid+urine -0.541666667 0 0 serum_phospholipids urine_cometabolism 0.97 0.215 no no no no no no DHA+blood 2-hydroxyhippuric acid+urine -0.536764706 0 0 serum_ARA urine_cometabolism 0.872 0.215 no no no no no no Faecalibacterium 2-hydroxyhippuric acid+urine 0 0.459649123 0 butyrate-producing Genus urine_cometabolism 0.0039 0.215 no dn dn no no no GCA+blood 2-hydroxyhippuric acid+urine 0.75 0 0 yes serum_bileacids urine_cometabolism 0.16 0.215 no no no no no no GCDCA+blood 2-hydroxyhippuric acid+urine 0.769607843 0 0 serum_bileacids urine_cometabolism 0.31 0.215 no no no no no no GUDCA+blood 2-hydroxyhippuric acid+urine 0.553921569 0 0 serum_bileacids urine_cometabolism 0.0766 0.215 no no dn no no no HCA+blood 2-hydroxyhippuric acid+urine 0.540984567 0 0 serum_bileacids urine_cometabolism 0.544 0.215 no no no no no no iso-DCA+blood 2-hydroxyhippuric acid+urine -0.669117647 0 0 serum_bileacids urine_cometabolism 0.38 0.215 no no no no no no L-Alanine+blood 2-hydroxyhippuric acid+urine 0.593137255 0 0 yes serum_aminoacids urine_cometabolism 0.00138 0.215 up up no no no no L-Homocystine+blood 2-hydroxyhippuric acid+urine 0 0 -0.548051948 serum_aminoacids urine_cometabolism 0.197 0.215 no no no no no no L-Ornithine+blood 2-hydroxyhippuric acid+urine 0.50245098 0 0 serum_aminoacids urine_cometabolism 0.175 0.215 no no no no no no Longevity regulating pathway 2-hydroxyhippuric acid+urine 0.456140351 0 0 kegg urine_cometabolism NA 0.215 no no no no no no Malaria 2-hydroxyhippuric acid+urine 0 0 -0.430769231 kegg urine_cometabolism NA 0.215 no no no no no no Prevotella 2-hydroxyhippuric acid+urine 0.487230422 0 0 acetate-producing Genus urine_cometabolism 0.287 0.215 no no no no no no Propionic acid+stool 2-hydroxyhippuric acid+urine 0 -0.833333333 0 yes stool_scfa urine_cometabolism 0.0436 0.215 dn no up no no no Small cell lung cancer 2-hydroxyhippuric acid+urine 0 0 -0.497692308 kegg urine_cometabolism NA 0.215 no no up no no no TDCA+blood 2-hydroxyhippuric acid+urine 0.500563625 0 0 yes serum_bileacids urine_cometabolism 0.155 0.215 no up no no no no total_stool_scfa+stool 2-hydroxyhippuric acid+urine 0 -0.75 0 stool_scfa urine_cometabolism 0.0534 0.215 dn no up no no no Transcriptional misregulation in cancer 2-hydroxyhippuric acid+urine 0 0 -0.405384615 kegg urine_cometabolism NA 0.215 no no no no no no 12-HEPE+blood 2-methyl-butyric acid m-C4+blood 0 0.615824986 0 serum_ARA serum_scfa 0.312 0.262 no no no no no no 16:0/16:0-PI+blood 2-methyl-butyric acid m-C4+blood -0.551879699 0 0 serum_phospholipids serum_scfa 0.358 0.262 no no no no no no 18:0/18:1-PI+blood 2-methyl-butyric acid m-C4+blood 0 0 0.457777778 serum_phospholipids serum_scfa 0.599 0.262 no no no no no no 18:0/18:2-PI+blood 2-methyl-butyric acid m-C4+blood 0 0 0.405128205 serum_phospholipids serum_scfa 0.179 0.262 no no no no no no 18:0+blood 2-methyl-butyric acid m-C4+blood 0.473684211 0 0 serum_fattyacid serum_scfa 0.344 0.262 no no no no no no 18:1/16:0-PI+blood 2-methyl-butyric acid m-C4+blood 0 0 0.431111111 serum_phospholipids serum_scfa 0.793 0.262 no no no no no no 18:1/18:0-PI+blood 2-methyl-butyric acid m-C4+blood 0 0 0.401025641 serum_phospholipids serum_scfa 0.0931 0.262 no no up no no no "Alanine, aspartate and glutamate metabolism" 2-Oxocarboxylic acid metabolism 0 -0.733201581 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism 2-Oxocarboxylic acid metabolism 0.659130435 0 0.506563707 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism 2-Oxocarboxylic acid metabolism 0.556521739 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis 2-Oxocarboxylic acid metabolism 0.70173913 0.754940711 0.454311454 kegg kegg NA NA no no no no no no Arginine and proline metabolism 2-Oxocarboxylic acid metabolism 0 -0.672924901 -0.408494208 kegg kegg NA NA no up no no no no Arginine biosynthesis 2-Oxocarboxylic acid metabolism 0 -0.769762846 -0.443500644 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism 2-Oxocarboxylic acid metabolism 0.432173913 0.608695652 0.492406692 kegg kegg NA NA no no no no no no beta-Alanine metabolism 2-Oxocarboxylic acid metabolism 0.842608696 0.52173913 0.496267696 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids 2-Oxocarboxylic acid metabolism 0.515652174 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism 2-Oxocarboxylic acid metabolism 0.890434783 0.815217391 0.551608752 kegg kegg NA NA no no no no no no Carbon metabolism 2-Oxocarboxylic acid metabolism 0.815652174 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) 2-Oxocarboxylic acid metabolism 0.799130435 0.802371542 0.772200772 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism 2-Oxocarboxylic acid metabolism 0 0.626482213 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 2-Oxocarboxylic acid metabolism 0 0.802371542 0.486229086 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes 2-Oxocarboxylic acid metabolism 0.728695652 0.766798419 0 kegg kegg NA NA no no no no no no Ether lipid metabolism 2-Oxocarboxylic acid metabolism 0 0.425889328 0.412355212 kegg kegg NA NA no no no no no no Fatty acid biosynthesis 2-Oxocarboxylic acid metabolism 0 -0.718379447 0 kegg kegg NA NA no no no no no no Fatty acid elongation 2-Oxocarboxylic acid metabolism 0.633043478 0 0.432947233 kegg kegg NA NA no no no no no no Folate biosynthesis 2-Oxocarboxylic acid metabolism 0 0.650197628 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism 2-Oxocarboxylic acid metabolism 0.686956522 0 0 kegg kegg NA NA no no no no no no Galactose metabolism 2-Oxocarboxylic acid metabolism 0.64173913 0 0.455341055 kegg kegg NA NA no no no no no no Glycerolipid metabolism 2-Oxocarboxylic acid metabolism 0 0 0.464607465 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" 2-Oxocarboxylic acid metabolism 0.456521739 0 -0.476962677 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis 2-Oxocarboxylic acid metabolism 0.780869565 0.537549407 0.465379665 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 2-Oxocarboxylic acid metabolism 0 -0.514822134 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin 2-Oxocarboxylic acid metabolism 0.767826087 0.801383399 0.648906049 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation 2-Oxocarboxylic acid metabolism 0 0 0.543629344 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series 2-Oxocarboxylic acid metabolism 0 0.760869565 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism 2-Oxocarboxylic acid metabolism 0 -0.770750988 0 kegg kegg NA NA no no no no no no Histidine metabolism 2-Oxocarboxylic acid metabolism 0.512173913 0 0 kegg kegg NA NA no no no no no no Lysine degradation 2-Oxocarboxylic acid metabolism 0 0.440711462 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis 2-Oxocarboxylic acid metabolism 0 0.423913043 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 2-Oxocarboxylic acid metabolism 0.442608696 0.787549407 0.47979408 kegg kegg NA NA no no no no no no N-Glycan biosynthesis 2-Oxocarboxylic acid metabolism 0 0.830039526 0.457915058 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism 2-Oxocarboxylic acid metabolism 0 -0.766798419 0 kegg kegg NA NA no no no no no no Nitrogen metabolism 2-Oxocarboxylic acid metabolism 0 -0.849802372 -0.602316602 kegg kegg NA NA no no no no no no One carbon pool by folate 2-Oxocarboxylic acid metabolism 0.407826087 0.712450593 0.607979408 kegg kegg NA NA no no no no no no Other glycan degradation 2-Oxocarboxylic acid metabolism 0 0 0.533333333 kegg kegg NA NA no no no no no no Oxidative phosphorylation 2-Oxocarboxylic acid metabolism -0.526086957 0 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis 2-Oxocarboxylic acid metabolism 0 -0.610671937 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions 2-Oxocarboxylic acid metabolism 0.524347826 0.874505929 0.813899614 kegg kegg NA NA no no no no no no Pentose phosphate pathway 2-Oxocarboxylic acid metabolism 0 -0.504940711 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism 2-Oxocarboxylic acid metabolism 0.809565217 0.787549407 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism 2-Oxocarboxylic acid metabolism 0.420869565 0 -0.445817246 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis 2-Oxocarboxylic acid metabolism 0.620869565 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism 2-Oxocarboxylic acid metabolism 0.46173913 0.551383399 0 kegg kegg NA NA no no no no no no Purine metabolism 2-Oxocarboxylic acid metabolism 0 0 -0.415958816 kegg kegg NA NA no no no no no no Pyrimidine metabolism 2-Oxocarboxylic acid metabolism 0.586956522 0.685770751 0 kegg kegg NA NA no no no no no no Pyruvate metabolism 2-Oxocarboxylic acid metabolism 0.551304348 0.624505929 0 kegg kegg NA NA no no no no no no Retinol metabolism 2-Oxocarboxylic acid metabolism 0.536521739 0.572134387 0.513256113 kegg kegg NA NA no no no no no no Selenocompound metabolism 2-Oxocarboxylic acid metabolism 0 0 0.403603604 kegg kegg NA NA no no no no no no Starch and sucrose metabolism 2-Oxocarboxylic acid metabolism 0 -0.563241107 0 kegg kegg NA NA no no no no no no Steroid biosynthesis 2-Oxocarboxylic acid metabolism 0 0 0.51042471 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis 2-Oxocarboxylic acid metabolism 0.463478261 0.480237154 0.446074646 kegg kegg NA NA no no no no no no Sulfur metabolism 2-Oxocarboxylic acid metabolism 0.508695652 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies 2-Oxocarboxylic acid metabolism 0.449565217 0.564229249 0.457400257 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis 2-Oxocarboxylic acid metabolism 0 0.457509881 0.530759331 kegg kegg NA NA no no no no no no Thiamine metabolism 2-Oxocarboxylic acid metabolism 0 0.454545455 0 kegg kegg NA NA no no no no no no Tryptophan metabolism 2-Oxocarboxylic acid metabolism 0.833913043 0.646245059 0.468725869 kegg kegg NA NA no up no no no no Tyrosine metabolism 2-Oxocarboxylic acid metabolism 0.696521739 0.610671937 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis 2-Oxocarboxylic acid metabolism 0.62 0.733201581 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" 2-Oxocarboxylic acid metabolism 0.782608696 0.806324111 0.593822394 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis 2-Oxocarboxylic acid metabolism 0 0.807312253 0.540797941 kegg kegg NA NA no no no no no no 12-HEPE+blood 20-HDOHE+blood 0.479990784 0 0 serum_ARA serum_ARA 0.312 0.205 no no no no no no 12-ketoDCA+blood 20:0-LPC+blood 0 0.589479532 -0.45456157 serum_bileacids serum_phospholipids 0.517 0.199 no no no no no no "12,13-EPOME+blood" 20:0-LPC+blood 0.529725363 -0.504817556 0 serum_ARA serum_phospholipids 0.901 0.199 no no no no no no 14:0/16:0-PC+blood 20:0-LPC+blood -0.572932331 0 0 serum_phospholipids serum_phospholipids 0.0358 0.199 no up no no no no 16:0/18:0-PC+blood 20:0-LPC+blood 0 0 0.428376068 serum_phospholipids serum_phospholipids 0.521 0.199 no no no no no no 16:1/16:0-PC+blood 20:0-LPC+blood 0 0 -0.497435897 serum_phospholipids serum_phospholipids 0.0215 0.199 no up up no no no 16:1/16:1-PC+blood 20:0-LPC+blood 0 0 -0.583589744 serum_phospholipids serum_phospholipids 0.0177 0.199 no no up no no no 18:0-LPC+blood 20:0-LPC+blood 0 0.720588235 0.617777778 serum_phospholipids serum_phospholipids 0.554 0.199 no no no no no no 18:0-LPE+blood 20:0-LPC+blood 0 0 0.433162393 serum_phospholipids serum_phospholipids 0.491 0.199 no no no no no no 18:0/18:0-PC+blood 20:0-LPC+blood 0 0 0.463247863 serum_phospholipids serum_phospholipids 0.426 0.199 no no no no no no 18:0/18:1-PC+blood 20:0-LPC+blood 0 0 0.484444444 serum_phospholipids serum_phospholipids 0.393 0.199 no no no no no no 18:0/20:2-PC+blood 20:0-LPC+blood 0 0 0.658119658 serum_phospholipids serum_phospholipids 0.733 0.199 no no no no no no 18:1-LPC+blood 20:0-LPC+blood 0 0.522058824 0.544615385 serum_phospholipids serum_phospholipids 0.179 0.199 no no no no no no 18:1-LPE+blood 20:0-LPC+blood 0 0 0.496752137 serum_phospholipids serum_phospholipids 0.117 0.199 no no no no no no 18:1/18:1-PI+blood 20:0-LPC+blood 0.586466165 0 0.432478632 serum_phospholipids serum_phospholipids 0.111 0.199 dn no no no no no 18:1/18:2-PI+blood 20:0-LPC+blood 0 0 0.412649573 serum_phospholipids serum_phospholipids 0.0164 0.199 dn no up no no no 18:1/20:3-PC+blood 20:0-LPC+blood 0 0.580882353 0 serum_phospholipids serum_phospholipids 0.00872 0.199 no up up no no no 18:2-LPC+blood 20:0-LPC+blood 0 0 0.419487179 serum_phospholipids serum_phospholipids 0.00743 0.199 dn no up no no no 18:2-LPE+blood 20:0-LPC+blood 0 0 0.414017094 serum_phospholipids serum_phospholipids 0.112 0.199 no no no no no no 18:2/18:1-PC+blood 20:0-LPC+blood 0 0 0.478974359 serum_phospholipids serum_phospholipids 2.30E-05 0.199 dn up up no no no 18:2/18:2-PC+blood 20:0-LPC+blood 0 0 0.491282051 serum_phospholipids serum_phospholipids 1.98E-05 0.199 dn up up no no no 18:2/20:4-PC+blood 20:0-LPC+blood 0 0.49754902 0.488547009 serum_phospholipids serum_phospholipids 0.0145 0.199 no no up no no no 18:3n3+blood 20:0-LPC+blood 0 -0.551470588 0 serum_fattyacid serum_phospholipids 0.291 0.199 no no no no no no 20:0+blood 20:0-LPC+blood 0 0.637254902 0 yes serum_fattyacid serum_phospholipids 0.000278 0.199 dn no up no no no 16:0/16:0-PI+blood 20:0-LPE+blood 0.598496241 0 0 serum_phospholipids serum_phospholipids 0.358 0.0615 no no no no no up 16:0/16:1-PI+blood 20:0-LPE+blood 0 0 -0.416752137 serum_phospholipids serum_phospholipids 0.262 0.0615 no no no no no up 16:0/18:0-PC+blood 20:0-LPE+blood 0 0 0.504957265 serum_phospholipids serum_phospholipids 0.521 0.0615 no no no no no up 16:0/18:0-PS+blood 20:0-LPE+blood 0 0 -0.434529915 serum_phospholipids serum_phospholipids 0.377 0.0615 no no no no no up 16:0/18:1-PC+blood 20:0-LPE+blood -0.67518797 0 -0.42017094 serum_phospholipids serum_phospholipids 6.15E-07 0.0615 up up up no no up 16:0/18:1-PE+blood 20:0-LPE+blood 0.577443609 0 0 serum_phospholipids serum_phospholipids 0.000107 0.0615 up up no no no up 16:0/18:2-PC+blood 20:0-LPE+blood -0.685714286 0 0 serum_phospholipids serum_phospholipids 3.24E-06 0.0615 no up up no no up 16:0/18:2-PI+blood 20:0-LPE+blood 0.612030075 0 0 serum_phospholipids serum_phospholipids 0.269 0.0615 no no no no no up 16:0/20:3-PC+blood 20:0-LPE+blood -0.464661654 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.0615 no up up no no up 16:0/20:4-PC+blood 20:0-LPE+blood -0.460150376 -0.504901961 0 serum_phospholipids serum_phospholipids 0.0262 0.0615 no up no no no up 16:0/20:4-PE+blood 20:0-LPE+blood 0 0 -0.434529915 serum_phospholipids serum_phospholipids 0.00139 0.0615 up up no no no up 16:0/20:4-PI+blood 20:0-LPE+blood 0.484210526 0 0 serum_phospholipids serum_phospholipids 0.558 0.0615 no no no no no up 16:0/22:6-PC+blood 20:0-LPE+blood -0.545864662 0 0 serum_phospholipids serum_phospholipids 4.53E-05 0.0615 no up up no no up 16:1/16:0-PC+blood 20:0-LPE+blood -0.586466165 0 0 serum_phospholipids serum_phospholipids 0.0215 0.0615 no up up no no up 16:1/16:1-PC+blood 20:0-LPE+blood -0.545864662 0 0 serum_phospholipids serum_phospholipids 0.0177 0.0615 no no up no no up 16:1/18:1-PG+blood 20:0-LPE+blood 0 0 -0.571965812 serum_phospholipids serum_phospholipids 3.21E-05 0.0615 no up up no no up 18:0-LPC+blood 20:0-LPE+blood 0 0.549019608 0.463931624 serum_phospholipids serum_phospholipids 0.554 0.0615 no no no no no up 18:0-LPE+blood 20:0-LPE+blood 0 0.566176471 0 serum_phospholipids serum_phospholipids 0.491 0.0615 no no no no no up 18:0/16:0-PC+blood 20:0-LPE+blood -0.657142857 0 -0.465982906 serum_phospholipids serum_phospholipids 9.64E-07 0.0615 up up up no no up 18:0/18:0-PE+blood 20:0-LPE+blood 0.461654135 0 0 serum_phospholipids serum_phospholipids 0.00896 0.0615 up up no no no up 18:0/18:0-PS+blood 20:0-LPE+blood 0 0 -0.463931624 serum_phospholipids serum_phospholipids 0.00617 0.0615 no up no no no up 18:0/18:1-PE+blood 20:0-LPE+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.00716 0.0615 up up no no no up 18:0/18:2-PC+blood 20:0-LPE+blood -0.652631579 0 0 serum_phospholipids serum_phospholipids 1.74E-06 0.0615 no up up no no up 18:0/18:2-PI+blood 20:0-LPE+blood 0.541353383 0 0 serum_phospholipids serum_phospholipids 0.179 0.0615 no no no no no up 18:0/20:2-PC+blood 20:0-LPE+blood 0 0 0.494017094 serum_phospholipids serum_phospholipids 0.733 0.0615 no no no no no up 18:0/20:4-PC+blood 20:0-LPE+blood -0.520300752 0 0 serum_phospholipids serum_phospholipids 0.454 0.0615 no no no no no up 18:0/20:5-PC+blood 20:0-LPE+blood -0.613533835 0 0 serum_phospholipids serum_phospholipids 0.17 0.0615 no no no no no up 18:0/22:6-PA+blood 20:0-LPE+blood 0 0 -0.446153846 serum_phospholipids serum_phospholipids 0.22 0.0615 no no no no no up 18:1-LPC+blood 20:0-LPE+blood 0 0 0.453675214 serum_phospholipids serum_phospholipids 0.179 0.0615 no no no no no up 18:1/16:0-PC+blood 20:0-LPE+blood -0.672180451 0 0 serum_phospholipids serum_phospholipids 2.43E-05 0.0615 no up up no no up 18:1/16:0-PI+blood 20:0-LPE+blood 0.545864662 0 0 serum_phospholipids serum_phospholipids 0.793 0.0615 no no no no no up 18:1/16:1-PE+blood 20:0-LPE+blood 0.452631579 0 0 serum_phospholipids serum_phospholipids 0.000184 0.0615 up up no no no up 18:1/18:0-PC+blood 20:0-LPE+blood -0.693233083 0 0 serum_phospholipids serum_phospholipids 1.83E-06 0.0615 no up up no no up 18:1/18:0-PI+blood 20:0-LPE+blood 0 0.68627451 0 serum_phospholipids serum_phospholipids 0.0931 0.0615 no no up no no up 18:1/18:0-PS+blood 20:0-LPE+blood -0.448120301 0 0 serum_phospholipids serum_phospholipids 0.193 0.0615 no no no no no up 18:1/18:1-PI+blood 20:0-LPE+blood 0 0.509803922 0 serum_phospholipids serum_phospholipids 0.111 0.0615 dn no no no no up 18:1/18:2-PE+blood 20:0-LPE+blood 0.520300752 0 0 serum_phospholipids serum_phospholipids 0.000293 0.0615 up up no no no up 18:1/18:2-PI+blood 20:0-LPE+blood 0 0.539215686 0.484444444 serum_phospholipids serum_phospholipids 0.0164 0.0615 dn no up no no up 18:2-LPC+blood 20:0-LPE+blood 0 0 0.515213675 serum_phospholipids serum_phospholipids 0.00743 0.0615 dn no up no no up 18:2/16:0-PC+blood 20:0-LPE+blood -0.488721805 0 0 serum_phospholipids serum_phospholipids 8.67E-05 0.0615 no up up no no up 18:2/18:1-PC+blood 20:0-LPE+blood 0 0 0.732649573 serum_phospholipids serum_phospholipids 2.30E-05 0.0615 dn up up no no up 18:2/18:2-PC+blood 20:0-LPE+blood 0 0 0.731282051 serum_phospholipids serum_phospholipids 1.98E-05 0.0615 dn up up no no up 18:2/20:4-PC+blood 20:0-LPE+blood 0 0 0.424957265 serum_phospholipids serum_phospholipids 0.0145 0.0615 no no up no no up 18:3/18:2-PC+blood 20:0-LPE+blood 0 0 0.605470085 serum_phospholipids serum_phospholipids 0.0394 0.0615 no no up no no up 20:0-LPC+blood 20:0-LPE+blood 0 0.509803922 0.574700855 serum_phospholipids serum_phospholipids 0.199 0.0615 no no no no no up 12-HEPE+blood 20:0/20:4-PE+blood 0 0 -0.438705301 serum_ARA serum_phospholipids 0.312 0.00128 no no no up up no 14:0-LPC+blood 20:0/20:4-PE+blood 0 0.659313725 0 serum_phospholipids serum_phospholipids 0.00689 0.00128 up up no up up no 14:0/18:0-PC+blood 20:0/20:4-PE+blood 0 0.539215686 0 serum_phospholipids serum_phospholipids 0.00289 0.00128 up up no up up no 14:0/18:2-PC+blood 20:0/20:4-PE+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.102 0.00128 no up no up up no 14:0/20:4-PC+blood 20:0/20:4-PE+blood 0 0 0.470769231 serum_phospholipids serum_phospholipids 0.486 0.00128 no no no up up no 14:1/18:2-PG+blood 20:0/20:4-PE+blood 0 0 0.44957265 serum_phospholipids serum_phospholipids 0.00259 0.00128 no up up up up no 16:0/16:0-PI+blood 20:0/20:4-PE+blood 0 0.517156863 0 serum_phospholipids serum_phospholipids 0.358 0.00128 no no no up up no 16:0/16:1-PC+blood 20:0/20:4-PE+blood 0 0.512254902 0 serum_phospholipids serum_phospholipids 0.00283 0.00128 up up no up up no 16:0/16:1-PI+blood 20:0/20:4-PE+blood 0 0.522058824 0 serum_phospholipids serum_phospholipids 0.262 0.00128 no no no up up no 16:0/18:0-PS+blood 20:0/20:4-PE+blood 0.49924812 0 0 serum_phospholipids serum_phospholipids 0.377 0.00128 no no no up up no 16:0/18:1-PC+blood 20:0/20:4-PE+blood 0 -0.556372549 0 serum_phospholipids serum_phospholipids 6.15E-07 0.00128 up up up up up no 16:0/18:1-PE+blood 20:0/20:4-PE+blood 0.538345865 0 0 serum_phospholipids serum_phospholipids 0.000107 0.00128 up up no up up no 16:0/18:2-PC+blood 20:0/20:4-PE+blood 0 -0.544117647 -0.419487179 serum_phospholipids serum_phospholipids 3.24E-06 0.00128 no up up up up no 16:0/18:2-PI+blood 20:0/20:4-PE+blood 0 0.732843137 0 serum_phospholipids serum_phospholipids 0.269 0.00128 no no no up up no 16:0/20:4-PC+blood 20:0/20:4-PE+blood 0 -0.524509804 0 serum_phospholipids serum_phospholipids 0.0262 0.00128 no up no up up no 16:0/20:4-PE+blood 20:0/20:4-PE+blood 0.556390977 0 0.401025641 serum_phospholipids serum_phospholipids 0.00139 0.00128 up up no up up no 16:0/20:4-PI+blood 20:0/20:4-PE+blood 0 0.590686275 0 serum_phospholipids serum_phospholipids 0.558 0.00128 no no no up up no 16:0/22:6-PC+blood 20:0/20:4-PE+blood -0.458646617 -0.656862745 -0.442051282 serum_phospholipids serum_phospholipids 4.53E-05 0.00128 no up up up up no 16:0/22:6-PE+blood 20:0/20:4-PE+blood 0.532330827 0 0.434529915 serum_phospholipids serum_phospholipids 0.000934 0.00128 up up no up up no 16:1/16:0-PC+blood 20:0/20:4-PE+blood 0 -0.62745098 -0.435897436 serum_phospholipids serum_phospholipids 0.0215 0.00128 no up up up up no 18:0-LPE+blood 20:0/20:4-PE+blood 0 0 0.519316239 serum_phospholipids serum_phospholipids 0.491 0.00128 no no no up up no 18:0/16:0-PC+blood 20:0/20:4-PE+blood 0 -0.595588235 0 serum_phospholipids serum_phospholipids 9.64E-07 0.00128 up up up up up no 18:0/18:0-PE+blood 20:0/20:4-PE+blood 0.578947368 0.522058824 0.715555556 serum_phospholipids serum_phospholipids 0.00896 0.00128 up up no up up no 18:0/18:0-PS+blood 20:0/20:4-PE+blood 0.478195489 0 0 serum_phospholipids serum_phospholipids 0.00617 0.00128 no up no up up no 18:0/18:1-PE+blood 20:0/20:4-PE+blood 0.571428571 0.612745098 0.66017094 serum_phospholipids serum_phospholipids 0.00716 0.00128 up up no up up no 18:0/18:1-PG+blood 20:0/20:4-PE+blood 0.586466165 0.531862745 0.441367521 serum_phospholipids serum_phospholipids 0.000842 0.00128 no up no up up no 18:0/18:2-PI+blood 20:0/20:4-PE+blood 0.481203008 0 0 serum_phospholipids serum_phospholipids 0.179 0.00128 no no no up up no 18:0/20:4-PC+blood 20:0/20:4-PE+blood 0 -0.519607843 0 serum_phospholipids serum_phospholipids 0.454 0.00128 no no no up up no 18:0/20:5-PC+blood 20:0/20:4-PE+blood 0 -0.541666667 0 serum_phospholipids serum_phospholipids 0.17 0.00128 no no no up up no 18:0/22:6-PC+blood 20:0/20:4-PE+blood -0.551879699 0 -0.444786325 serum_phospholipids serum_phospholipids 0.0775 0.00128 no no up up up no 18:1/16:0-PC+blood 20:0/20:4-PE+blood 0 -0.544117647 -0.432478632 serum_phospholipids serum_phospholipids 2.43E-05 0.00128 no up up up up no 18:1/16:0-PE+blood 20:0/20:4-PE+blood 0.62556391 0 0.702564103 serum_phospholipids serum_phospholipids 0.000182 0.00128 up up no up up no 18:1/18:0-PE+blood 20:0/20:4-PE+blood 0.473684211 0.580882353 0.574700855 serum_phospholipids serum_phospholipids 1.39E-06 0.00128 up up no up up no 18:1/18:1-PE+blood 20:0/20:4-PE+blood 0.554887218 0.546568627 0.620512821 serum_phospholipids serum_phospholipids 1.03E-05 0.00128 up up no up up no 18:1/18:2-PE+blood 20:0/20:4-PE+blood 0.497744361 0.519607843 0.536410256 serum_phospholipids serum_phospholipids 0.000293 0.00128 up up no up up no 18:1/20:4-PC+blood 20:0/20:4-PE+blood 0 -0.519607843 0 serum_phospholipids serum_phospholipids 0.582 0.00128 no no no up up no 18:1/20:4-PE+blood 20:0/20:4-PE+blood 0.590977444 0 0.663589744 serum_phospholipids serum_phospholipids 0.0578 0.00128 up no no up up no 18:2/18:2-PS+blood 20:0/20:4-PE+blood 0.487218045 0 0 serum_phospholipids serum_phospholipids 0.00674 0.00128 up up no up up no 18:3/16:0-PE+blood 20:0/20:4-PE+blood 0.481203008 0.600490196 0.439316239 serum_phospholipids serum_phospholipids 0.00149 0.00128 up up no up up no 18:3n6+blood 20:0/20:4-PE+blood 0 0.556372549 0 serum_fattyacid serum_phospholipids 0.0463 0.00128 up no dn up up no 14:0-LPC+blood 20:0/20:5-PC+blood -0.583458647 0 0 serum_phospholipids serum_phospholipids 0.00689 0.882 up up no no no no 16:0/14:0-PC+blood 20:0/20:5-PC+blood 0 0 0.452307692 serum_phospholipids serum_phospholipids 0.0206 0.882 no up up no no no 16:0/16:1-PI+blood 20:0/20:5-PC+blood -0.560902256 0 0 serum_phospholipids serum_phospholipids 0.262 0.882 no no no no no no 16:0/18:1-PC+blood 20:0/20:5-PC+blood 0.506766917 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.882 up up up no no no 16:0/18:2-PC+blood 20:0/20:5-PC+blood 0 0 0.408547009 serum_phospholipids serum_phospholipids 3.24E-06 0.882 no up up no no no 16:0/18:2-PI+blood 20:0/20:5-PC+blood -0.497744361 0 0 serum_phospholipids serum_phospholipids 0.269 0.882 no no no no no no 16:0/20:4-PC+blood 20:0/20:5-PC+blood 0.454135338 0 0.615042735 serum_phospholipids serum_phospholipids 0.0262 0.882 no up no no no no 16:0/20:5-PG+blood 20:0/20:5-PC+blood 0.810526316 0 0 serum_phospholipids serum_phospholipids 0.00656 0.882 no up no no no no 16:0/22:6-PC+blood 20:0/20:5-PC+blood 0 0.56127451 0 serum_phospholipids serum_phospholipids 4.53E-05 0.882 no up up no no no 16:1/16:0-PC+blood 20:0/20:5-PC+blood 0.476691729 0.490196078 0 serum_phospholipids serum_phospholipids 0.0215 0.882 no up up no no no 16:1/16:1-PC+blood 20:0/20:5-PC+blood 0.744360902 0 0 serum_phospholipids serum_phospholipids 0.0177 0.882 no no up no no no 16:1/18:1-PG+blood 20:0/20:5-PC+blood 0.661654135 0 -0.500854701 serum_phospholipids serum_phospholipids 3.21E-05 0.882 no up up no no no 16:1/18:2-PG+blood 20:0/20:5-PC+blood 0.581954887 0 -0.461880342 serum_phospholipids serum_phospholipids 1.40E-08 0.882 no up up no no no 18:0/16:0-PC+blood 20:0/20:5-PC+blood 0.542857143 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.882 up up up no no no 18:0/18:2-PC+blood 20:0/20:5-PC+blood 0 0 0.484444444 serum_phospholipids serum_phospholipids 1.74E-06 0.882 no up up no no no 18:0/20:3-PI+blood 20:0/20:5-PC+blood 0.521804511 0 0 serum_phospholipids serum_phospholipids 0.377 0.882 no no no no no no 18:0/20:4-PC+blood 20:0/20:5-PC+blood 0.637593985 0.615196078 0.711452991 serum_phospholipids serum_phospholipids 0.454 0.882 no no no no no no 18:0/20:4-PI+blood 20:0/20:5-PC+blood 0.733834586 0 0 serum_phospholipids serum_phospholipids 0.167 0.882 no no no no no no 18:0/20:5-PC+blood 20:0/20:5-PC+blood 0 0.593137255 0.809230769 serum_phospholipids serum_phospholipids 0.17 0.882 no no no no no no 18:0/22:6-PA+blood 20:0/20:5-PC+blood 0.448120301 0 0 serum_phospholipids serum_phospholipids 0.22 0.882 no no no no no no 18:0/22:6-PC+blood 20:0/20:5-PC+blood 0 0.742647059 0.441367521 serum_phospholipids serum_phospholipids 0.0775 0.882 no no up no no no 18:0/22:6-PI+blood 20:0/20:5-PC+blood 0 0.590686275 0 serum_phospholipids serum_phospholipids 0.425 0.882 no no no no no no 18:1-LPE+blood 20:0/20:5-PC+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.117 0.882 no no no no no no 18:1/16:0-PC+blood 20:0/20:5-PC+blood 0 0 0.413333333 serum_phospholipids serum_phospholipids 2.43E-05 0.882 no up up no no no 18:1/18:0-PC+blood 20:0/20:5-PC+blood 0 0 0.446153846 serum_phospholipids serum_phospholipids 1.83E-06 0.882 no up up no no no 18:1/18:0-PS+blood 20:0/20:5-PC+blood 0.723308271 0 0 serum_phospholipids serum_phospholipids 0.193 0.882 no no no no no no 18:1/18:1-PG+blood 20:0/20:5-PC+blood 0.523308271 0 0 serum_phospholipids serum_phospholipids 0.00352 0.882 no up up no no no 18:1/18:2-PE+blood 20:0/20:5-PC+blood 0 -0.509803922 0 serum_phospholipids serum_phospholipids 0.000293 0.882 up up no no no no 18:1/18:2-PG+blood 20:0/20:5-PC+blood 0.529323308 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.882 no up up no no no 18:1/20:3-PC+blood 20:0/20:5-PC+blood 0 0 0.601367521 serum_phospholipids serum_phospholipids 0.00872 0.882 no up up no no no 18:1/20:4-PC+blood 20:0/20:5-PC+blood 0.763909774 0.715686275 0.695726496 serum_phospholipids serum_phospholipids 0.582 0.882 no no no no no no 18:1/20:4-PI+blood 20:0/20:5-PC+blood 0 0 0.591111111 serum_phospholipids serum_phospholipids 0.192 0.882 no no no no no no 18:2-LPC+blood 20:0/20:5-PC+blood 0 -0.590686275 0 serum_phospholipids serum_phospholipids 0.00743 0.882 dn no up no no no 18:2-LPE+blood 20:0/20:5-PC+blood -0.52481203 -0.637254902 0 serum_phospholipids serum_phospholipids 0.112 0.882 no no no no no no 18:2/18:1-PC+blood 20:0/20:5-PC+blood 0 -0.632352941 0 serum_phospholipids serum_phospholipids 2.30E-05 0.882 dn up up no no no 18:2/18:2-PC+blood 20:0/20:5-PC+blood 0 -0.615196078 0 serum_phospholipids serum_phospholipids 1.98E-05 0.882 dn up up no no no 18:2/18:2-PS+blood 20:0/20:5-PC+blood 0 0 -0.542564103 serum_phospholipids serum_phospholipids 0.00674 0.882 up up no no no no 18:2/20:4-PC+blood 20:0/20:5-PC+blood 0 0 0.501538462 serum_phospholipids serum_phospholipids 0.0145 0.882 no no up no no no 18:2n6c+blood 20:0/20:5-PC+blood 0 -0.659313725 0 serum_fattyacid serum_phospholipids 0.15 0.882 no no no no no no 18:3-LPC+blood 20:0/20:5-PC+blood -0.596992481 0 0 serum_phospholipids serum_phospholipids 0.147 0.882 no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool 20:0/20:5-PC+blood 0 0 -0.44962406 stool_cometabolism serum_phospholipids 0.33 0.882 no no no no no no Alzheimer disease 20:0/20:5-PC+blood 0 0 -0.444615385 kegg serum_phospholipids NA 0.882 no no no no no no AMPK signaling pathway 20:0/20:5-PC+blood -0.461403509 0 0 kegg serum_phospholipids NA 0.882 no no no no no no Biosynthesis of amino acids 20:0/20:5-PC+blood 0 0 0.421538462 kegg serum_phospholipids NA 0.882 no no no no no no Biosynthesis of cofactors 20:0/20:5-PC+blood -0.58245614 0 0 kegg serum_phospholipids NA 0.882 no no no no no no CA+stool 20:0/20:5-PC+blood 0 0 -0.473684211 stool_bileacids serum_phospholipids 0.827 0.882 no no no no no no cAMP signaling pathway 20:0/20:5-PC+blood 0 -0.523529412 0 yes kegg serum_phospholipids NA 0.882 no up up no no no Cardiac muscle contraction 20:0/20:5-PC+blood 0 0 -0.431538462 kegg serum_phospholipids NA 0.882 no no up no no no Clostridium 20:0/20:5-PC+blood 0 0 -0.513848839 Genus serum_phospholipids 0.925 0.882 no no no no no no Diabetic cardiomyopathy 20:0/20:5-PC+blood 0 0 -0.456153846 kegg serum_phospholipids NA 0.882 no no no no no no Epstein-Barr virus infection 20:0/20:5-PC+blood 0 -0.647058824 0 kegg serum_phospholipids NA 0.882 no no no no no no Fc gamma R-mediated phagocytosis 20:0/20:5-PC+blood 0.478947368 0 0 kegg serum_phospholipids NA 0.882 no no no no no no "Glycine, serine and threonine metabolism" 20:0/20:5-PC+blood -0.571929825 0 0 kegg serum_phospholipids NA 0.882 no up no no no no Herpes simplex virus 1 infection 20:0/20:5-PC+blood 0 -0.611764706 -0.443076923 kegg serum_phospholipids NA 0.882 no no no no no no Human cytomegalovirus infection 20:0/20:5-PC+blood 0 -0.676470588 0 kegg serum_phospholipids NA 0.882 no no dn no no no Human immunodeficiency virus 1 infection 20:0/20:5-PC+blood 0 -0.670588235 0 kegg serum_phospholipids NA 0.882 no no no no no no Human T-cell leukemia virus 1 infection 20:0/20:5-PC+blood 0 -0.652941176 -0.423076923 kegg serum_phospholipids NA 0.882 no no no no no no IL-17 signaling pathway 20:0/20:5-PC+blood 0.464912281 0 0 kegg serum_phospholipids NA 0.882 no no no no no no Kaposi sarcoma-associated herpesvirus infection 20:0/20:5-PC+blood 0 -0.664705882 0 kegg serum_phospholipids NA 0.882 no no dn no no no Lachnospira 20:0/20:5-PC+blood 0 0 0.631507775 butyrate-producing Genus serum_phospholipids 0.279 0.882 no no no no no no Lipid and atherosclerosis 20:0/20:5-PC+blood 0.529824561 0 0 kegg serum_phospholipids NA 0.882 no no no no no no Long-term potentiation 20:0/20:5-PC+blood 0 0 -0.423846154 kegg serum_phospholipids NA 0.882 no no up no no no Mitophagy - animal 20:0/20:5-PC+blood -0.614035088 0 0 kegg serum_phospholipids NA 0.882 no no no no no no mTOR signaling pathway 20:0/20:5-PC+blood -0.463157895 0 0 kegg serum_phospholipids NA 0.882 no no no no no no NOD-like receptor signaling pathway 20:0/20:5-PC+blood 0.528070175 0 0 kegg serum_phospholipids NA 0.882 no no no no no no Non-alcoholic fatty liver disease 20:0/20:5-PC+blood 0 -0.544117647 0 kegg serum_phospholipids NA 0.882 no no no no no no Oxidative phosphorylation 20:0/20:5-PC+blood 0 0 -0.45 kegg serum_phospholipids NA 0.882 no no no no no no Parabacteroides 20:0/20:5-PC+blood 0 0.490196078 0 Genus serum_phospholipids 4.19E-05 0.882 no up up no no no Peroxisome 20:0/20:5-PC+blood 0 0 0.504615385 kegg serum_phospholipids NA 0.882 no no no no no no Porphyrin and chlorophyll metabolism 20:0/20:5-PC+blood -0.487719298 0 0 kegg serum_phospholipids NA 0.882 no no no no no no Prevotella 20:0/20:5-PC+blood -0.510033147 0 0 acetate-producing Genus serum_phospholipids 0.287 0.882 no no no no no no Prion disease 20:0/20:5-PC+blood 0 0 -0.522307692 kegg serum_phospholipids NA 0.882 no no no no no no Proteoglycans in cancer 20:0/20:5-PC+blood -0.598245614 0 0 kegg serum_phospholipids NA 0.882 no no no no no no Ras signaling pathway 20:0/20:5-PC+blood 0 0 -0.466923077 yes kegg serum_phospholipids NA 0.882 no up up no no no Retrograde endocannabinoid signaling 20:0/20:5-PC+blood 0 0 -0.616923077 kegg serum_phospholipids NA 0.882 no no up no no no Shigellosis 20:0/20:5-PC+blood -0.487719298 -0.526470588 0 kegg serum_phospholipids NA 0.882 no no no no no no Systemic lupus erythematosus 20:0/20:5-PC+blood 0.545614035 0 0 kegg serum_phospholipids NA 0.882 no no no no no no TCA+stool 20:0/20:5-PC+blood 0 -0.672727273 0 stool_bileacids serum_phospholipids 0.458 0.882 no no no no no no Th1 and Th2 cell differentiation 20:0/20:5-PC+blood 0 0 -0.451538462 kegg serum_phospholipids NA 0.882 no no no no no no Th17 cell differentiation 20:0/20:5-PC+blood 0 0 -0.409230769 kegg serum_phospholipids NA 0.882 no no no no no no Thermogenesis 20:0/20:5-PC+blood 0 0 -0.496153846 kegg serum_phospholipids NA 0.882 no no no no no no Tuberculosis 20:0/20:5-PC+blood 0.468421053 0 0 kegg serum_phospholipids NA 0.882 no no dn no no no Ubiquitin mediated proteolysis 20:0/20:5-PC+blood -0.610526316 0 0 kegg serum_phospholipids NA 0.882 no no no no no no UDCA+stool 20:0/20:5-PC+blood 0 0 -0.482706767 stool_bileacids serum_phospholipids 0.266 0.882 no no no no no no "12,13-EPOME+blood" 20:0+blood 0 -0.49980696 0 yes serum_ARA serum_fattyacid 0.901 0.000278 no no no dn no up 15-HETE+blood 20:0+blood 0 -0.527753557 0 yes serum_ARA serum_fattyacid 0.819 0.000278 no no no dn no up 16:0-LPC+blood 20:0+blood 0 0 0.499487179 yes serum_phospholipids serum_fattyacid 0.00456 0.000278 up up no dn no up 16:0-LPE+blood 20:0+blood 0 0 0.517948718 yes serum_phospholipids serum_fattyacid 0.0711 0.000278 up up no dn no up 16:0/16:0-PI+blood 20:0+blood -0.470676692 0 0 yes serum_phospholipids serum_fattyacid 0.358 0.000278 no no no dn no up 16:0/16:1-PI+blood 20:0+blood 0 0 0.503589744 yes serum_phospholipids serum_fattyacid 0.262 0.000278 no no no dn no up 16:0/18:2-PI+blood 20:0+blood -0.446616541 0 0.498119658 yes serum_phospholipids serum_fattyacid 0.269 0.000278 no no no dn no up 16:0/20:4-PI+blood 20:0+blood 0 0 0.432478632 yes serum_phospholipids serum_fattyacid 0.558 0.000278 no no no dn no up 18:0/18:0-PS+blood 20:0+blood -0.566917293 0 0 yes serum_phospholipids serum_fattyacid 0.00617 0.000278 no up no dn no up 18:0/22:6-PC+blood 20:0+blood -0.473684211 0 0 yes serum_phospholipids serum_fattyacid 0.0775 0.000278 no no up dn no up 18:0/22:6-PE+blood 20:0+blood -0.466165414 0 0 yes serum_phospholipids serum_fattyacid 0.00022 0.000278 up up no dn no up 18:0/22:6-PI+blood 20:0+blood -0.660150376 0 0 yes serum_phospholipids serum_fattyacid 0.425 0.000278 no no no dn no up 18:1-LPC+blood 20:0+blood 0.622556391 0 0 yes serum_phospholipids serum_fattyacid 0.179 0.000278 no no no dn no up 18:1/18:1-PC+blood 20:0+blood 0.520300752 0 0 yes serum_phospholipids serum_fattyacid 1.34E-05 0.000278 no up up dn no up 18:1/20:3-PC+blood 20:0+blood 0 0.531862745 0 yes serum_phospholipids serum_fattyacid 0.00872 0.000278 no up up dn no up 18:2-LPA+blood 20:0+blood 0 -0.553921569 0 yes serum_phospholipids serum_fattyacid 0.00684 0.000278 dn no up dn no up 18:2-LPC+blood 20:0+blood 0.470676692 0 0 yes serum_phospholipids serum_fattyacid 0.00743 0.000278 dn no up dn no up 18:2/18:1-PC+blood 20:0+blood 0.566917293 0 0 yes serum_phospholipids serum_fattyacid 2.30E-05 0.000278 dn up up dn no up 18:2/18:2-PC+blood 20:0+blood 0.633082707 0 0 yes serum_phospholipids serum_fattyacid 1.98E-05 0.000278 dn up up dn no up 18:2/20:4-PC+blood 20:0+blood 0 0.529411765 0 yes serum_phospholipids serum_fattyacid 0.0145 0.000278 no no up dn no up 18:3-LPC+blood 20:0+blood 0 -0.551470588 0.428376068 yes serum_phospholipids serum_fattyacid 0.147 0.000278 no no no dn no up 18:3/16:0-PE+blood 20:0+blood 0 0 0.421538462 yes serum_phospholipids serum_fattyacid 0.00149 0.000278 up up no dn no up 18:3n3+blood 20:0+blood 0 -0.553921569 0 yes serum_fattyacid serum_fattyacid 0.291 0.000278 no no no dn no up Aldosterone synthesis and secretion 20:0+blood 0 0 0.44 yes kegg serum_fattyacid NA 0.000278 no up up dn no up Alistipes 20:0+blood 0 0.486817995 0 yes Genus serum_fattyacid 0.0114 0.000278 no up no dn no up Amyotrophic lateral sclerosis 20:0+blood 0.51754386 0 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Anaerostipes 20:0+blood -0.505187765 0 0 butyrate-producing yes Genus serum_fattyacid 0.568 0.000278 no no no dn no up Asthma 20:0+blood 0 0 -0.466923077 yes kegg serum_fattyacid NA 0.000278 no no no dn no up B cell receptor signaling pathway 20:0+blood 0 0 0.401538462 yes kegg serum_fattyacid NA 0.000278 no no no dn no up C-type lectin receptor signaling pathway 20:0+blood 0 0 0.406923077 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Calcium signaling pathway 20:0+blood 0 0 0.514615385 yes kegg serum_fattyacid NA 0.000278 no up up dn no up cAMP signaling pathway 20:0+blood 0 0 0.641538462 yes yes kegg serum_fattyacid NA 0.000278 no up up dn no up Carbon metabolism 20:0+blood 0 0 -0.58 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Cardiac muscle contraction 20:0+blood 0.524561404 0 0 yes kegg serum_fattyacid NA 0.000278 no no up dn no up Central carbon metabolism in cancer 20:0+blood -0.489473684 0 -0.413076923 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Chagas disease 20:0+blood 0.480701754 0 0.457692308 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Chronic myeloid leukemia 20:0+blood 0 0 0.622307692 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Cocaine addiction 20:0+blood 0 0 0.617692308 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Colorectal cancer 20:0+blood 0 0.55 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Cortisol synthesis and secretion 20:0+blood 0 0 0.595384615 yes kegg serum_fattyacid NA 0.000278 no no up dn no up Cushing syndrome 20:0+blood 0 0 0.461538462 yes kegg serum_fattyacid NA 0.000278 no no up dn no up Cytosolic DNA-sensing pathway 20:0+blood 0.633333333 0 0.463846154 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Diabetic cardiomyopathy 20:0+blood 0.524561404 0 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Endocrine and other factor-regulated calcium reabsorption 20:0+blood 0 0 0.444615385 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Endocrine resistance 20:0+blood 0 0 0.402307692 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Focal adhesion 20:0+blood 0 0 -0.429230769 yes kegg serum_fattyacid NA 0.000278 no up up dn no up Gastric cancer 20:0+blood 0 0.561764706 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Glycolysis / Gluconeogenesis 20:0+blood 0 0 -0.786153846 yes kegg serum_fattyacid NA 0.000278 no no no dn no up "Growth hormone synthesis, secretion and action" 20:0+blood 0 0 0.419230769 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Hematopoietic cell lineage 20:0+blood 0 0 -0.556153846 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Hepatitis C 20:0+blood 0 0 0.420769231 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Huntington disease 20:0+blood 0.531578947 0 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Inflammatory bowel disease 20:0+blood 0 0 -0.43 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Insulin resistance 20:0+blood 0 0 0.453846154 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Insulin secretion 20:0+blood 0 0 0.623846154 yes yes kegg serum_fattyacid NA 0.000278 no up up dn no up Kaposi sarcoma-associated herpesvirus infection 20:0+blood 0.575438596 0 0 yes kegg serum_fattyacid NA 0.000278 no no dn dn no up Lachnospira 20:0+blood -0.603007519 0 0 butyrate-producing yes Genus serum_fattyacid 0.279 0.000278 no no no dn no up Leishmaniasis 20:0+blood 0 0 -0.469230769 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Long-term depression 20:0+blood 0 0 0.443076923 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Longevity regulating pathway - multiple species 20:0+blood -0.633333333 0 -0.566923077 yes kegg serum_fattyacid NA 0.000278 no no no dn no up MAPK signaling pathway 20:0+blood 0 0 -0.43 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Mineral absorption 20:0+blood 0 0 0.439230769 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Morphine addiction 20:0+blood 0 0 0.520769231 yes kegg serum_fattyacid NA 0.000278 no up up dn no up Neurotrophin signaling pathway 20:0+blood 0 0 0.406153846 yes kegg serum_fattyacid NA 0.000278 no no no dn no up NF-kappa B signaling pathway 20:0+blood 0 0 0.406923077 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Non-alcoholic fatty liver disease 20:0+blood 0.475438596 0 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Olfactory transduction 20:0+blood -0.5 0 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Oxidative phosphorylation 20:0+blood 0.468421053 0 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Pancreatic secretion 20:0+blood 0.456140351 0 0.453076923 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Parabacteroides 20:0+blood 0 0.490196078 0.425029926 yes Genus serum_fattyacid 4.19E-05 0.000278 no up up dn no up Parkinson disease 20:0+blood 0.561403509 0 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Pathways in cancer 20:0+blood 0 0.508823529 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Pathways of neurodegeneration - multiple diseases 20:0+blood 0.58245614 0 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Peroxisome 20:0+blood -0.654385965 0 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Phenylacetic acid+stool 20:0+blood 0.681318681 0 0 yes stool_cometabolism serum_fattyacid 0.785 0.000278 no no no dn no up Prevotella 20:0+blood 0 0 0.551795687 acetate-producing yes Genus serum_fattyacid 0.287 0.000278 no no no dn no up Primary immunodeficiency 20:0+blood -0.58245614 0 -0.550769231 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Prion disease 20:0+blood 0.542105263 0 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Prostate cancer 20:0+blood 0 0 0.520769231 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Proteoglycans in cancer 20:0+blood 0 0 -0.419230769 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Regulation of lipolysis in adipocytes 20:0+blood 0 0 0.401538462 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Relaxin signaling pathway 20:0+blood 0.524561404 0 0.599230769 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Rheumatoid arthritis 20:0+blood 0 0 -0.54 yes kegg serum_fattyacid NA 0.000278 no no no dn no up RIG-I-like receptor signaling pathway 20:0+blood 0 0 0.423076923 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Ruminococcus 20:0+blood 0 -0.646229429 0 yes Genus serum_fattyacid 0.0679 0.000278 no no dn dn no up Salmonella infection 20:0+blood 0 0 -0.476923077 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Shigellosis 20:0+blood 0.568421053 0 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Signaling pathways regulating pluripotency of stem cells 20:0+blood 0 0.520588235 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Small cell lung cancer 20:0+blood 0 0 0.613846154 yes kegg serum_fattyacid NA 0.000278 no no up dn no up TCA+stool 20:0+blood -0.718019936 0 0 yes stool_bileacids serum_fattyacid 0.458 0.000278 no no no dn no up Th1 and Th2 cell differentiation 20:0+blood 0.663157895 0 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Th17 cell differentiation 20:0+blood 0.607017544 0 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Thermogenesis 20:0+blood 0.473684211 0 0 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Thyroid hormone synthesis 20:0+blood 0 0 0.446153846 yes kegg serum_fattyacid NA 0.000278 no no no dn no up TNF signaling pathway 20:0+blood 0 0 0.52 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Toxoplasmosis 20:0+blood 0 0 -0.454615385 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Transcriptional misregulation in cancer 20:0+blood 0 0 0.414615385 yes kegg serum_fattyacid NA 0.000278 no no no dn no up Tuberculosis 20:0+blood 0 0 -0.429230769 yes kegg serum_fattyacid NA 0.000278 no no dn dn no up 16:0/20:5-PG+blood 20:1-LPA+blood 0 0 0.40991453 serum_phospholipids serum_phospholipids 0.00656 0.0187 no up no dn dn no 16:0/22:6-PE+blood 20:1-LPA+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.000934 0.0187 up up no dn dn no 16:1/16:1-PC+blood 20:1-LPA+blood 0 0 -0.43042735 serum_phospholipids serum_phospholipids 0.0177 0.0187 no no up dn dn no 16:1/18:2-PG+blood 20:1-LPA+blood 0.47518797 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.0187 no up up dn dn no 16:1+blood 20:1-LPA+blood 0 0 -0.532991453 yes serum_fattyacid serum_phospholipids 0.0186 0.0187 no no dn dn dn no 18:0-LPA+blood 20:1-LPA+blood 0 0.81372549 0 serum_phospholipids serum_phospholipids 0.0725 0.0187 no dn no dn dn no 18:2-LPA+blood 20:1-LPA+blood 0 0.590686275 0 serum_phospholipids serum_phospholipids 0.00684 0.0187 dn no up dn dn no 18:2/16:0-PC+blood 20:1-LPA+blood 0.482706767 0 0 serum_phospholipids serum_phospholipids 8.67E-05 0.0187 no up up dn dn no 18:2n6c+blood 20:1-LPA+blood 0 0 -0.477606838 serum_fattyacid serum_phospholipids 0.15 0.0187 no no no dn dn no 18:3n3+blood 20:1-LPA+blood 0.547368421 0 -0.411282051 serum_fattyacid serum_phospholipids 0.291 0.0187 no no no dn dn no 4-hydroxybenzoic acid+stool 20:1-LPA+blood 0.763736264 0 0 stool_cometabolism serum_phospholipids 0.0536 0.0187 no dn no dn dn no Adrenergic signaling in cardiomyocytes 20:1-LPA+blood 0 -0.529411765 0 kegg serum_phospholipids NA 0.0187 no no up dn dn no Aldosterone synthesis and secretion 20:1-LPA+blood 0 -0.6 0 kegg serum_phospholipids NA 0.0187 no up up dn dn no Allograft rejection 20:1-LPA+blood 0 0.508823529 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Amphetamine addiction 20:1-LPA+blood 0 -0.514705882 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Apoptosis 20:1-LPA+blood 0 0.517647059 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Autoimmune thyroid disease 20:1-LPA+blood 0 0.508823529 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Bacteroides 20:1-LPA+blood 0 -0.49754902 0 LPS-producing Genus serum_phospholipids 0.000267 0.0187 dn dn up dn dn no Butyricimonas 20:1-LPA+blood 0 -0.777140508 0 butyrate-producing Genus serum_phospholipids 0.17 0.0187 no no no dn dn no Cell adhesion molecules 20:1-LPA+blood 0 0.529411765 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Cell cycle 20:1-LPA+blood 0 -0.585294118 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Chemical carcinogenesis - receptor activation 20:1-LPA+blood 0 -0.585294118 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Clostridium 20:1-LPA+blood 0 0 0.472386999 Genus serum_phospholipids 0.925 0.0187 no no no dn dn no Collinsella 20:1-LPA+blood 0 0 0.507790373 Genus serum_phospholipids 0.128 0.0187 no no no dn dn no Cushing syndrome 20:1-LPA+blood 0 -0.588235294 0 kegg serum_phospholipids NA 0.0187 no no up dn dn no DCA+stool 20:1-LPA+blood -0.565934066 0 0 stool_bileacids serum_phospholipids 0.195 0.0187 no no no dn dn no Dopaminergic synapse 20:1-LPA+blood 0 -0.629411765 0 kegg serum_phospholipids NA 0.0187 no up no dn dn no Endocytosis 20:1-LPA+blood 0 0.532352941 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Fc gamma R-mediated phagocytosis 20:1-LPA+blood 0 0.617647059 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Gemmiger 20:1-LPA+blood -0.592481203 0 0 butyrate-producing Genus serum_phospholipids 0.595 0.0187 no no no dn dn no Glucagon signaling pathway 20:1-LPA+blood 0 -0.526470588 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Graft-versus-host disease 20:1-LPA+blood 0 0.508823529 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no HDCA+stool 20:1-LPA+blood 0 0 -0.476691729 stool_bileacids serum_phospholipids 0.176 0.0187 no no no dn dn no IL-17 signaling pathway 20:1-LPA+blood 0 0.670588235 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Influenza A 20:1-LPA+blood 0 0.755882353 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no L-Tyrosine+stool 20:1-LPA+blood 0.571428571 0 0 stool_cometabolism serum_phospholipids 0.44 0.0187 no no no dn dn no Lipid and atherosclerosis 20:1-LPA+blood 0 0.667647059 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Lysosome 20:1-LPA+blood 0 0.605882353 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Morphine addiction 20:1-LPA+blood 0 -0.585294118 0 kegg serum_phospholipids NA 0.0187 no up up dn dn no mRNA surveillance pathway 20:1-LPA+blood 0 -0.585294118 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Necroptosis 20:1-LPA+blood -0.459649123 0 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Neuroactive ligand-receptor interaction 20:1-LPA+blood 0 0.620588235 0 kegg serum_phospholipids NA 0.0187 up up up dn dn no Neutrophil extracellular trap formation 20:1-LPA+blood 0 0.541176471 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no NF-kappa B signaling pathway 20:1-LPA+blood 0 0 -0.423076923 kegg serum_phospholipids NA 0.0187 no no no dn dn no Olfactory transduction 20:1-LPA+blood 0 0.5 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Oscillospira 20:1-LPA+blood -0.648120301 0 0 LPS-producing Genus serum_phospholipids 0.62 0.0187 no no no dn dn no Osteoclast differentiation 20:1-LPA+blood 0 0.567647059 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Peroxisome 20:1-LPA+blood 0 0.570588235 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Pertussis 20:1-LPA+blood 0 0.620588235 0 kegg serum_phospholipids NA 0.0187 no no dn dn dn no Phagosome 20:1-LPA+blood 0 0.520588235 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Protein processing in endoplasmic reticulum 20:1-LPA+blood 0 -0.620588235 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Ras signaling pathway 20:1-LPA+blood 0 -0.682352941 0 yes kegg serum_phospholipids NA 0.0187 no up up dn dn no Retrograde endocannabinoid signaling 20:1-LPA+blood 0 -0.514705882 0 kegg serum_phospholipids NA 0.0187 no no up dn dn no Rheumatoid arthritis 20:1-LPA+blood 0 0.723529412 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no RNA degradation 20:1-LPA+blood 0 -0.538235294 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Salmonella infection 20:1-LPA+blood 0.489473684 0.576470588 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Spinocerebellar ataxia 20:1-LPA+blood 0 -0.517647059 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Staphylococcus aureus infection 20:1-LPA+blood 0 0.717647059 0 kegg serum_phospholipids NA 0.0187 up no no dn dn no Systemic lupus erythematosus 20:1-LPA+blood 0 0.588235294 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Th1 and Th2 cell differentiation 20:1-LPA+blood 0 0.538235294 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Thyroid hormone synthesis 20:1-LPA+blood 0 -0.602941176 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Toll-like receptor signaling pathway 20:1-LPA+blood 0 0.523529412 0 yes kegg serum_phospholipids NA 0.0187 no no no dn dn no Toxoplasmosis 20:1-LPA+blood 0 0.682352941 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Tuberculosis 20:1-LPA+blood 0 0.673529412 0 kegg serum_phospholipids NA 0.0187 no no dn dn dn no Type I diabetes mellitus 20:1-LPA+blood 0 0.508823529 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Viral myocarditis 20:1-LPA+blood 0 0.511764706 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Wnt signaling pathway 20:1-LPA+blood 0 -0.558823529 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no Yersinia infection 20:1-LPA+blood 0.459649123 0.564705882 0 kegg serum_phospholipids NA 0.0187 no no no dn dn no "12,13-EPOME+blood" 20:1-LPC+blood 0 -0.534881132 0 serum_ARA serum_phospholipids 0.901 0.217 no no no no no no 14:0/18:0-PC+blood 20:1-LPC+blood 0 0 -0.445470085 serum_phospholipids serum_phospholipids 0.00289 0.217 up up no no no no 14:0+blood 20:1-LPC+blood -0.55037594 0 -0.483760684 yes serum_fattyacid serum_phospholipids 0.00572 0.217 up no dn no no no 16:0/16:0-PI+blood 20:1-LPC+blood 0 0 -0.472820513 serum_phospholipids serum_phospholipids 0.358 0.217 no no no no no no 16:0/16:1-PC+blood 20:1-LPC+blood 0 0 -0.483076923 serum_phospholipids serum_phospholipids 0.00283 0.217 up up no no no no 16:0/16:1-PI+blood 20:1-LPC+blood 0 0 -0.493333333 serum_phospholipids serum_phospholipids 0.262 0.217 no no no no no no 16:0/18:0-PC+blood 20:1-LPC+blood 0 0 0.63008547 serum_phospholipids serum_phospholipids 0.521 0.217 no no no no no no 16:0/18:1-PE+blood 20:1-LPC+blood 0 0 -0.635555556 serum_phospholipids serum_phospholipids 0.000107 0.217 up up no no no no 16:0/18:2-PI+blood 20:1-LPC+blood -0.497744361 -0.544117647 -0.428376068 serum_phospholipids serum_phospholipids 0.269 0.217 no no no no no no 16:0/20:4-PE+blood 20:1-LPC+blood 0 0 -0.505641026 serum_phospholipids serum_phospholipids 0.00139 0.217 up up no no no no 16:0/20:4-PI+blood 20:1-LPC+blood 0 0 -0.442735043 serum_phospholipids serum_phospholipids 0.558 0.217 no no no no no no 16:0/22:0-PE+blood 20:1-LPC+blood 0 0 0.591111111 serum_phospholipids serum_phospholipids 0.00839 0.217 dn no up no no no 16:0/22:6-PE+blood 20:1-LPC+blood 0 0 -0.507008547 serum_phospholipids serum_phospholipids 0.000934 0.217 up up no no no no 16:1+blood 20:1-LPC+blood 0 0 -0.637606838 yes serum_fattyacid serum_phospholipids 0.0186 0.217 no no dn no no no 18:0-LPC+blood 20:1-LPC+blood 0 0 0.527521368 serum_phospholipids serum_phospholipids 0.554 0.217 no no no no no no 18:0/18:0-PC+blood 20:1-LPC+blood 0 0 0.630769231 serum_phospholipids serum_phospholipids 0.426 0.217 no no no no no no 18:0/18:0-PE+blood 20:1-LPC+blood 0 -0.575980392 0 serum_phospholipids serum_phospholipids 0.00896 0.217 up up no no no no 18:0/18:1-PC+blood 20:1-LPC+blood 0 0 0.604102564 serum_phospholipids serum_phospholipids 0.393 0.217 no no no no no no 18:0/18:1-PE+blood 20:1-LPC+blood 0 -0.546568627 0 serum_phospholipids serum_phospholipids 0.00716 0.217 up up no no no no 18:0/18:1-PG+blood 20:1-LPC+blood 0 0 -0.567179487 serum_phospholipids serum_phospholipids 0.000842 0.217 no up no no no no 18:0/20:2-PC+blood 20:1-LPC+blood 0 0 0.74017094 serum_phospholipids serum_phospholipids 0.733 0.217 no no no no no no 18:0/22:6-PI+blood 20:1-LPC+blood -0.505263158 0 0 serum_phospholipids serum_phospholipids 0.425 0.217 no no no no no no 18:1-LPC+blood 20:1-LPC+blood 0.703759398 0.791666667 0.64034188 serum_phospholipids serum_phospholipids 0.179 0.217 no no no no no no 18:1/16:0-PE+blood 20:1-LPC+blood 0 0 -0.524102564 serum_phospholipids serum_phospholipids 0.000182 0.217 up up no no no no 18:1/16:1-PE+blood 20:1-LPC+blood 0 0 -0.657435897 serum_phospholipids serum_phospholipids 0.000184 0.217 up up no no no no 18:1/18:0-PE+blood 20:1-LPC+blood 0 0 -0.608205128 serum_phospholipids serum_phospholipids 1.39E-06 0.217 up up no no no no 18:1/18:1-PE+blood 20:1-LPC+blood 0 0 -0.522735043 serum_phospholipids serum_phospholipids 1.03E-05 0.217 up up no no no no 18:1/18:1-PI+blood 20:1-LPC+blood 0.533834586 0 0.466666667 serum_phospholipids serum_phospholipids 0.111 0.217 dn no no no no no 18:1/20:3-PC+blood 20:1-LPC+blood 0 0.580882353 0 serum_phospholipids serum_phospholipids 0.00872 0.217 no up up no no no 18:1/20:4-PC+blood 20:1-LPC+blood 0 0.50245098 0 serum_phospholipids serum_phospholipids 0.582 0.217 no no no no no no 18:2-LPC+blood 20:1-LPC+blood 0 0 0.498803419 serum_phospholipids serum_phospholipids 0.00743 0.217 dn no up no no no 18:2/18:1-PC+blood 20:1-LPC+blood 0.551879699 0 0.403760684 serum_phospholipids serum_phospholipids 2.30E-05 0.217 dn up up no no no 18:2/18:2-PC+blood 20:1-LPC+blood 0.556390977 0 0 serum_phospholipids serum_phospholipids 1.98E-05 0.217 dn up up no no no 18:3/16:0-PE+blood 20:1-LPC+blood 0 0 -0.608205128 serum_phospholipids serum_phospholipids 0.00149 0.217 up up no no no no 20:0-LPC+blood 20:1-LPC+blood 0.452631579 0.742647059 0.522051282 serum_phospholipids serum_phospholipids 0.199 0.217 no no no no no no 20:0+blood 20:1-LPC+blood 0.717293233 0.62254902 0 yes serum_fattyacid serum_phospholipids 0.000278 0.217 dn no up no no no 20:1-LPA+blood 20:1-LPC+blood 0 0 0.411282051 serum_phospholipids serum_phospholipids 0.0187 0.217 dn dn no no no no 20:1+blood 20:1-LPC+blood 0.566917293 0.553921569 0.492649573 yes serum_fattyacid serum_phospholipids 2.56E-05 0.217 dn dn dn no no no "12,13-EPOME+blood" 20:1-LPE+blood 0 -0.502312258 0 serum_ARA serum_phospholipids 0.901 0.465 no no no no no no 16:0/20:4-PC+blood 20:1-LPE+blood 0 0.514705882 0 serum_phospholipids serum_phospholipids 0.0262 0.465 no up no no no no 16:0/20:5-PC+blood 20:1-LPE+blood 0 0 -0.420854701 serum_phospholipids serum_phospholipids 0.628 0.465 no no no no no no 18:0/18:0-PE+blood 20:1-LPE+blood 0 -0.585784314 0 serum_phospholipids serum_phospholipids 0.00896 0.465 up up no no no no 18:0/18:1-PE+blood 20:1-LPE+blood 0 -0.531862745 0 serum_phospholipids serum_phospholipids 0.00716 0.465 up up no no no no 18:0/20:4-PC+blood 20:1-LPE+blood 0 0.536764706 0 serum_phospholipids serum_phospholipids 0.454 0.465 no no no no no no 18:1-LPC+blood 20:1-LPE+blood 0.569924812 0 0 serum_phospholipids serum_phospholipids 0.179 0.465 no no no no no no 18:1-LPE+blood 20:1-LPE+blood 0.535338346 0 0.56991453 serum_phospholipids serum_phospholipids 0.117 0.465 no no no no no no 18:1/18:1-PI+blood 20:1-LPE+blood 0 0 0.537777778 serum_phospholipids serum_phospholipids 0.111 0.465 dn no no no no no 18:2-LPA+blood 20:1-LPE+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.00684 0.465 dn no up no no no 18:2-LPC+blood 20:1-LPE+blood 0 0 0.444786325 serum_phospholipids serum_phospholipids 0.00743 0.465 dn no up no no no 18:2/18:1-PC+blood 20:1-LPE+blood 0 0 0.532307692 serum_phospholipids serum_phospholipids 2.30E-05 0.465 dn up up no no no 18:2/18:2-PC+blood 20:1-LPE+blood 0 0 0.522735043 serum_phospholipids serum_phospholipids 1.98E-05 0.465 dn up up no no no 18:2/20:4-PC+blood 20:1-LPE+blood 0 0 0.502905983 serum_phospholipids serum_phospholipids 0.0145 0.465 no no up no no no 18:3/18:2-PC+blood 20:1-LPE+blood 0 0 0.455042735 serum_phospholipids serum_phospholipids 0.0394 0.465 no no up no no no 20:0-LPC+blood 20:1-LPE+blood 0 0.593137255 0.424273504 serum_phospholipids serum_phospholipids 0.199 0.465 no no no no no no 20:0+blood 20:1-LPE+blood 0.630075188 0.740196078 0 yes serum_fattyacid serum_phospholipids 0.000278 0.465 dn no up no no no 20:1-LPC+blood 20:1-LPE+blood 0.661654135 0.632352941 0.405811966 serum_phospholipids serum_phospholipids 0.217 0.465 no no no no no no 14:0-LPC+blood 20:1/20:4-PC+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.00689 0.0419 up up no no no up 14:1/18:2-PG+blood 20:1/20:4-PC+blood 0.466165414 0 0 serum_phospholipids serum_phospholipids 0.00259 0.0419 no up up no no up 16:0/14:0-PC+blood 20:1/20:4-PC+blood 0 0 0.547350427 serum_phospholipids serum_phospholipids 0.0206 0.0419 no up up no no up 16:0/16:0-PC+blood 20:1/20:4-PC+blood 0.458646617 0 0.446153846 serum_phospholipids serum_phospholipids 0.00079 0.0419 no up up no no up 16:0/18:1-PC+blood 20:1/20:4-PC+blood 0 0.580882353 0 serum_phospholipids serum_phospholipids 6.15E-07 0.0419 up up up no no up 16:0/18:2-PC+blood 20:1/20:4-PC+blood 0.49924812 0 0.650598291 serum_phospholipids serum_phospholipids 3.24E-06 0.0419 no up up no no up 16:0/20:3-PC+blood 20:1/20:4-PC+blood 0.472180451 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.0419 no up up no no up 16:0/22:0-PE+blood 20:1/20:4-PC+blood 0.735338346 0.639705882 0.604786325 serum_phospholipids serum_phospholipids 0.00839 0.0419 dn no up no no up 16:0/22:6-PC+blood 20:1/20:4-PC+blood 0.810526316 0.710784314 0.852307692 serum_phospholipids serum_phospholipids 4.53E-05 0.0419 no up up no no up 16:1/16:0-PC+blood 20:1/20:4-PC+blood 0.505263158 0.828431373 0.625299145 serum_phospholipids serum_phospholipids 0.0215 0.0419 no up up no no up 18:0/16:0-PC+blood 20:1/20:4-PC+blood 0 0.56372549 0 serum_phospholipids serum_phospholipids 9.64E-07 0.0419 up up up no no up 18:0/18:0-PC+blood 20:1/20:4-PC+blood 0 0.492647059 0 serum_phospholipids serum_phospholipids 0.426 0.0419 no no no no no up 18:0/18:1-PG+blood 20:1/20:4-PC+blood 0 0 -0.403076923 serum_phospholipids serum_phospholipids 0.000842 0.0419 no up no no no up 18:0/18:2-PC+blood 20:1/20:4-PC+blood 0.563909774 0 0.667692308 serum_phospholipids serum_phospholipids 1.74E-06 0.0419 no up up no no up 18:0/20:4-PC+blood 20:1/20:4-PC+blood 0 0.549019608 0.509059829 serum_phospholipids serum_phospholipids 0.454 0.0419 no no no no no up 18:0/20:5-PC+blood 20:1/20:4-PC+blood 0.496240602 0.482843137 0.562393162 serum_phospholipids serum_phospholipids 0.17 0.0419 no no no no no up 18:0/22:6-PC+blood 20:1/20:4-PC+blood 0.969924812 0.906862745 0.942564103 serum_phospholipids serum_phospholipids 0.0775 0.0419 no no up no no up 18:0/22:6-PI+blood 20:1/20:4-PC+blood 0.493233083 0.754901961 0 serum_phospholipids serum_phospholipids 0.425 0.0419 no no no no no up 18:1-LPE+blood 20:1/20:4-PC+blood -0.556390977 0 0 serum_phospholipids serum_phospholipids 0.117 0.0419 no no no no no up 18:1/16:0-PC+blood 20:1/20:4-PC+blood 0.502255639 0 0.642393162 serum_phospholipids serum_phospholipids 2.43E-05 0.0419 no up up no no up 18:1/16:0-PE+blood 20:1/20:4-PC+blood -0.557894737 0 0 serum_phospholipids serum_phospholipids 0.000182 0.0419 up up no no no up 18:1/18:0-PC+blood 20:1/20:4-PC+blood 0.577443609 0 0.655384615 serum_phospholipids serum_phospholipids 1.83E-06 0.0419 no up up no no up 18:1/18:2-PE+blood 20:1/20:4-PC+blood 0 0 -0.414700855 serum_phospholipids serum_phospholipids 0.000293 0.0419 up up no no no up 18:1/20:4-PC+blood 20:1/20:4-PC+blood 0 0.580882353 0.496068376 serum_phospholipids serum_phospholipids 0.582 0.0419 no no no no no up 18:1/22:6-PE+blood 20:1/20:4-PC+blood 0 0.590686275 0.476923077 serum_phospholipids serum_phospholipids 0.0047 0.0419 no up no no no up 18:2-LPC+blood 20:1/20:4-PC+blood 0 -0.531862745 0 serum_phospholipids serum_phospholipids 0.00743 0.0419 dn no up no no up 18:2/16:0-PC+blood 20:1/20:4-PC+blood 0 0 0.458461538 serum_phospholipids serum_phospholipids 8.67E-05 0.0419 no up up no no up 18:2/18:1-PC+blood 20:1/20:4-PC+blood 0 -0.661764706 0 serum_phospholipids serum_phospholipids 2.30E-05 0.0419 dn up up no no up 18:2/18:2-PC+blood 20:1/20:4-PC+blood 0 -0.671568627 0 serum_phospholipids serum_phospholipids 1.98E-05 0.0419 dn up up no no up 18:2/20:4-PC+blood 20:1/20:4-PC+blood 0.457142857 0 0 serum_phospholipids serum_phospholipids 0.0145 0.0419 no no up no no up 18:3/16:0-PE+blood 20:1/20:4-PC+blood 0 -0.519607843 0 serum_phospholipids serum_phospholipids 0.00149 0.0419 up up no no no up 20:0/20:4-PE+blood 20:1/20:4-PC+blood -0.57593985 -0.534313725 -0.406495726 serum_phospholipids serum_phospholipids 0.00128 0.0419 up up no no no up 20:0/20:5-PC+blood 20:1/20:4-PC+blood 0 0.693627451 0.611623932 serum_phospholipids serum_phospholipids 0.882 0.0419 no no no no no up 13-HODE+blood 20:1/20:4-PE+blood 0 -0.495098039 0 serum_ARA serum_phospholipids 0.32 0.0042 no no no up up no 14:0-LPC+blood 20:1/20:4-PE+blood -0.476691729 0 0 serum_phospholipids serum_phospholipids 0.00689 0.0042 up up no up up no 14:1/18:2-PG+blood 20:1/20:4-PE+blood -0.473684211 0 0.40034188 serum_phospholipids serum_phospholipids 0.00259 0.0042 no up up up up no 16:0/18:0-PS+blood 20:1/20:4-PE+blood 0.554887218 0.514705882 0.467350427 serum_phospholipids serum_phospholipids 0.377 0.0042 no no no up up no 16:0/18:1-PE+blood 20:1/20:4-PE+blood 0 0 0.552820513 serum_phospholipids serum_phospholipids 0.000107 0.0042 up up no up up no 16:0/20:4-PE+blood 20:1/20:4-PE+blood 0 0.514705882 0.593846154 serum_phospholipids serum_phospholipids 0.00139 0.0042 up up no up up no 16:0/20:4-PI+blood 20:1/20:4-PE+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 0.558 0.0042 no no no up up no 16:0/20:5-PG+blood 20:1/20:4-PE+blood 0.634586466 0 0 serum_phospholipids serum_phospholipids 0.00656 0.0042 no up no up up no 16:0/22:6-PE+blood 20:1/20:4-PE+blood 0.587969925 0.593137255 0.633504274 serum_phospholipids serum_phospholipids 0.000934 0.0042 up up no up up no 16:1+blood 20:1/20:4-PE+blood 0 0.566176471 0 yes serum_fattyacid serum_phospholipids 0.0186 0.0042 no no dn up up no 18:0-LPE+blood 20:1/20:4-PE+blood 0 0 0.48034188 serum_phospholipids serum_phospholipids 0.491 0.0042 no no no up up no 18:0/18:0-PE+blood 20:1/20:4-PE+blood 0 0 0.524102564 serum_phospholipids serum_phospholipids 0.00896 0.0042 up up no up up no 18:0/18:0-PS+blood 20:1/20:4-PE+blood 0.518796992 0.598039216 0.441367521 serum_phospholipids serum_phospholipids 0.00617 0.0042 no up no up up no 18:0/18:1-PE+blood 20:1/20:4-PE+blood 0 0.588235294 0.504957265 serum_phospholipids serum_phospholipids 0.00716 0.0042 up up no up up no 18:0/18:1-PG+blood 20:1/20:4-PE+blood 0 0.737745098 0.579487179 serum_phospholipids serum_phospholipids 0.000842 0.0042 no up no up up no 18:0/18:2-PI+blood 20:1/20:4-PE+blood 0.502255639 0 0 serum_phospholipids serum_phospholipids 0.179 0.0042 no no no up up no 18:0/20:4-PI+blood 20:1/20:4-PE+blood 0.648120301 0 0.455726496 serum_phospholipids serum_phospholipids 0.167 0.0042 no no no up up no 18:0/22:6-PE+blood 20:1/20:4-PE+blood 0 0.595588235 0.528205128 serum_phospholipids serum_phospholipids 0.00022 0.0042 up up no up up no 18:1/16:0-PE+blood 20:1/20:4-PE+blood 0 0.524509804 0.732649573 serum_phospholipids serum_phospholipids 0.000182 0.0042 up up no up up no 18:1/16:1-PE+blood 20:1/20:4-PE+blood 0 0 0.56991453 serum_phospholipids serum_phospholipids 0.000184 0.0042 up up no up up no 18:1/18:0-PE+blood 20:1/20:4-PE+blood 0 0.573529412 0.682735043 serum_phospholipids serum_phospholipids 1.39E-06 0.0042 up up no up up no 18:1/18:0-PS+blood 20:1/20:4-PE+blood 0.481203008 0 0 serum_phospholipids serum_phospholipids 0.193 0.0042 no no no up up no 18:1/18:1-PE+blood 20:1/20:4-PE+blood 0.454135338 0.615196078 0.66974359 serum_phospholipids serum_phospholipids 1.03E-05 0.0042 up up no up up no 18:1/18:2-PE+blood 20:1/20:4-PE+blood 0 0 0.469401709 serum_phospholipids serum_phospholipids 0.000293 0.0042 up up no up up no 18:1/20:4-PE+blood 20:1/20:4-PE+blood 0.792481203 0.808823529 0.780512821 serum_phospholipids serum_phospholipids 0.0578 0.0042 up no no up up no 18:1/22:6-PE+blood 20:1/20:4-PE+blood 0.596992481 0 0 serum_phospholipids serum_phospholipids 0.0047 0.0042 no up no up up no 18:2-LPA+blood 20:1/20:4-PE+blood 0 0 -0.42974359 serum_phospholipids serum_phospholipids 0.00684 0.0042 dn no up up up no 18:2-LPC+blood 20:1/20:4-PE+blood 0 0 -0.509059829 serum_phospholipids serum_phospholipids 0.00743 0.0042 dn no up up up no 18:2-LPE+blood 20:1/20:4-PE+blood -0.446616541 0 0 serum_phospholipids serum_phospholipids 0.112 0.0042 no no no up up no 18:3/16:0-PE+blood 20:1/20:4-PE+blood 0 0.529411765 0.539145299 serum_phospholipids serum_phospholipids 0.00149 0.0042 up up no up up no 18:3n6+blood 20:1/20:4-PE+blood 0 0.485294118 0 serum_fattyacid serum_phospholipids 0.0463 0.0042 up no dn up up no 20:0/20:4-PE+blood 20:1/20:4-PE+blood 0.727819549 0.68627451 0.856410256 serum_phospholipids serum_phospholipids 0.00128 0.0042 up up no up up no 20:0/20:5-PC+blood 20:1/20:4-PE+blood 0.633082707 0 0 serum_phospholipids serum_phospholipids 0.882 0.0042 no no no up up no 20:1-LPC+blood 20:1/20:4-PE+blood 0 0 -0.419487179 serum_phospholipids serum_phospholipids 0.217 0.0042 no no no up up no 14:0/16:0-PC+blood 20:1+blood -0.460150376 0 0 yes serum_phospholipids serum_fattyacid 0.0358 2.56E-05 no up no dn dn dn 15-HETE+blood 20:1+blood 0.446982524 -0.537618109 -0.559892923 yes serum_ARA serum_fattyacid 0.819 2.56E-05 no no no dn dn dn 16:0/16:0-PI+blood 20:1+blood -0.545864662 0 0 yes serum_phospholipids serum_fattyacid 0.358 2.56E-05 no no no dn dn dn 16:0/16:1-PI+blood 20:1+blood -0.454135338 0 0 yes serum_phospholipids serum_fattyacid 0.262 2.56E-05 no no no dn dn dn 16:0/18:1-PE+blood 20:1+blood 0 0 -0.461196581 yes serum_phospholipids serum_fattyacid 0.000107 2.56E-05 up up no dn dn dn 16:0/18:2-PI+blood 20:1+blood -0.518796992 -0.553921569 0 yes serum_phospholipids serum_fattyacid 0.269 2.56E-05 no no no dn dn dn 16:0/18:3-PC+blood 20:1+blood 0 -0.490196078 0 yes serum_phospholipids serum_fattyacid 0.00216 2.56E-05 no up up dn dn dn 16:0/20:5-PC+blood 20:1+blood 0 0 -0.498119658 yes serum_phospholipids serum_fattyacid 0.628 2.56E-05 no no no dn dn dn 16:0/22:6-PE+blood 20:1+blood 0 0 -0.496068376 yes serum_phospholipids serum_fattyacid 0.000934 2.56E-05 up up no dn dn dn 18:0-LPC+blood 20:1+blood 0 0 0.416068376 yes serum_phospholipids serum_fattyacid 0.554 2.56E-05 no no no dn dn dn 18:0/18:0-PC+blood 20:1+blood 0 0 0.473504274 yes serum_phospholipids serum_fattyacid 0.426 2.56E-05 no no no dn dn dn 18:0/18:1-PC+blood 20:1+blood 0 0 0.494700855 yes serum_phospholipids serum_fattyacid 0.393 2.56E-05 no no no dn dn dn 18:0/18:1-PI+blood 20:1+blood 0 0 0.602051282 yes serum_phospholipids serum_fattyacid 0.599 2.56E-05 no no no dn dn dn 18:0/20:2-PC+blood 20:1+blood 0 0 0.487179487 yes serum_phospholipids serum_fattyacid 0.733 2.56E-05 no no no dn dn dn 18:0/22:6-PA+blood 20:1+blood -0.469172932 0 0 yes serum_phospholipids serum_fattyacid 0.22 2.56E-05 no no no dn dn dn 18:0/22:6-PE+blood 20:1+blood 0 0 -0.491965812 yes serum_phospholipids serum_fattyacid 0.00022 2.56E-05 up up no dn dn dn 18:0/22:6-PI+blood 20:1+blood -0.67518797 0 0 yes serum_phospholipids serum_fattyacid 0.425 2.56E-05 no no no dn dn dn 18:1-LPC+blood 20:1+blood 0.487218045 0.634803922 0 yes serum_phospholipids serum_fattyacid 0.179 2.56E-05 no no no dn dn dn 18:1/16:0-PI+blood 20:1+blood 0 0 0.446837607 yes serum_phospholipids serum_fattyacid 0.793 2.56E-05 no no no dn dn dn 18:1/16:1-PE+blood 20:1+blood 0 0 -0.403760684 yes serum_phospholipids serum_fattyacid 0.000184 2.56E-05 up up no dn dn dn 18:1/18:1-PI+blood 20:1+blood 0 0 0.599316239 yes serum_phospholipids serum_fattyacid 0.111 2.56E-05 dn no no dn dn dn 18:1/20:4-PE+blood 20:1+blood 0 0 -0.40034188 yes serum_phospholipids serum_fattyacid 0.0578 2.56E-05 up no no dn dn dn 18:1/22:6-PE+blood 20:1+blood 0 0 -0.401025641 yes serum_phospholipids serum_fattyacid 0.0047 2.56E-05 no up no dn dn dn 18:1+blood 20:1+blood 0 0.556372549 0 yes yes serum_fattyacid serum_fattyacid 0.00202 2.56E-05 up no dn dn dn dn 18:2/18:1-PC+blood 20:1+blood 0.458646617 0 0 yes serum_phospholipids serum_fattyacid 2.30E-05 2.56E-05 dn up up dn dn dn 18:2/18:2-PC+blood 20:1+blood 0.467669173 0 0 yes serum_phospholipids serum_fattyacid 1.98E-05 2.56E-05 dn up up dn dn dn 2-methyl-butyric acid m-C4+blood 20:1+blood 0.485714286 0 0 yes serum_scfa serum_fattyacid 0.262 2.56E-05 no no no dn dn dn 20:0-LPC+blood 20:1+blood 0 0 0.493333333 yes serum_phospholipids serum_fattyacid 0.199 2.56E-05 no no no dn dn dn 20:0+blood 20:1+blood 0.684210526 0 0 yes yes serum_fattyacid serum_fattyacid 0.000278 2.56E-05 dn no up dn dn dn Acetic acid+stool 20:1+blood 0 0.727272727 0 yes yes stool_scfa serum_fattyacid 0.0656 2.56E-05 dn no no dn dn dn Adipocytokine signaling pathway 20:1+blood 0.557894737 0 0 yes kegg serum_fattyacid NA 2.56E-05 no no no dn dn dn Amoebiasis 20:1+blood 0 0 -0.408461538 yes kegg serum_fattyacid NA 2.56E-05 no no no dn dn dn Anaerostipes 20:1+blood -0.4488018 0 0 butyrate-producing yes Genus serum_fattyacid 0.568 2.56E-05 no no no dn dn dn Central carbon metabolism in cancer 20:1+blood -0.463157895 0 0 yes kegg serum_fattyacid NA 2.56E-05 no no no dn dn dn Cytosolic DNA-sensing pathway 20:1+blood 0.521052632 0 0 yes kegg serum_fattyacid NA 2.56E-05 no no no dn dn dn Dorea 20:1+blood 0 -0.490196078 0 yes Genus serum_fattyacid 0.00362 2.56E-05 up no dn dn dn dn GABAergic synapse 20:1+blood 0 0 -0.49 yes kegg serum_fattyacid NA 2.56E-05 no up up dn dn dn Glutamatergic synapse 20:1+blood 0 0 -0.448461538 yes kegg serum_fattyacid NA 2.56E-05 no up up dn dn dn Insulin resistance 20:1+blood 0 0 0.417692308 yes kegg serum_fattyacid NA 2.56E-05 no no no dn dn dn Insulin signaling pathway 20:1+blood -0.457894737 0 0 yes kegg serum_fattyacid NA 2.56E-05 no no no dn dn dn Longevity regulating pathway - multiple species 20:1+blood -0.480701754 0 0 yes kegg serum_fattyacid NA 2.56E-05 no no no dn dn dn Oocyte meiosis 20:1+blood -0.478947368 0 0 yes kegg serum_fattyacid NA 2.56E-05 no no no dn dn dn Oxytocin signaling pathway 20:1+blood 0 0 -0.423846154 yes kegg serum_fattyacid NA 2.56E-05 no no no dn dn dn Phenylacetic acid+stool 20:1+blood 0.813186813 0 0 yes stool_cometabolism serum_fattyacid 0.785 2.56E-05 no no no dn dn dn Primary immunodeficiency 20:1+blood -0.536842105 0 0 yes kegg serum_fattyacid NA 2.56E-05 no no no dn dn dn Roseburia 20:1+blood 0 0 -0.417435897 butyrate-producing yes Genus serum_fattyacid 0.495 2.56E-05 no no no dn dn dn Ruminococcus 20:1+blood 0 -0.605763449 0 yes Genus serum_fattyacid 0.0679 2.56E-05 no no dn dn dn dn Salivary secretion 20:1+blood 0 0 -0.426923077 yes kegg serum_fattyacid NA 2.56E-05 no no no dn dn dn Th1 and Th2 cell differentiation 20:1+blood 0.563157895 0 0.608461538 yes kegg serum_fattyacid NA 2.56E-05 no no no dn dn dn Th17 cell differentiation 20:1+blood 0 0 0.554615385 yes kegg serum_fattyacid NA 2.56E-05 no no no dn dn dn Tight junction 20:1+blood 0 0 -0.411538462 yes kegg serum_fattyacid NA 2.56E-05 no no no dn dn dn total_stool_scfa+stool 20:1+blood 0 0.681818182 0 yes stool_scfa serum_fattyacid 0.0534 2.56E-05 dn no up dn dn dn "12,13-EPOME+blood" 20:2-LPC+blood 0 0 -0.413651647 serum_ARA serum_phospholipids 0.901 0.119 no no no no no up 13-HODE+blood 20:2-LPC+blood 0.57593985 0 0 serum_ARA serum_phospholipids 0.32 0.119 no no no no no up 16:0-LPC+blood 20:2-LPC+blood 0.512781955 -0.514705882 0 serum_phospholipids serum_phospholipids 0.00456 0.119 up up no no no up 16:0-LPE+blood 20:2-LPC+blood -0.557894737 0 0 serum_phospholipids serum_phospholipids 0.0711 0.119 up up no no no up 16:0/14:0-PC+blood 20:2-LPC+blood 0 0.49754902 0.610940171 serum_phospholipids serum_phospholipids 0.0206 0.119 no up up no no up 16:0/16:0-PC+blood 20:2-LPC+blood 0 0 0.431794872 serum_phospholipids serum_phospholipids 0.00079 0.119 no up up no no up 16:0/18:0-PC+blood 20:2-LPC+blood 0 0 0.594529915 serum_phospholipids serum_phospholipids 0.521 0.119 no no no no no up 16:0/18:0-PS+blood 20:2-LPC+blood 0 0 -0.604102564 serum_phospholipids serum_phospholipids 0.377 0.119 no no no no no up 16:0/18:1-PE+blood 20:2-LPC+blood 0 0 -0.44957265 serum_phospholipids serum_phospholipids 0.000107 0.119 up up no no no up 16:0/20:3-PC+blood 20:2-LPC+blood 0.612030075 0.509803922 0.587692308 serum_phospholipids serum_phospholipids 5.43E-06 0.119 no up up no no up 16:0/20:4-PE+blood 20:2-LPC+blood 0 0 -0.469401709 serum_phospholipids serum_phospholipids 0.00139 0.119 up up no no no up 16:0/20:5-PC+blood 20:2-LPC+blood -0.679699248 0 0 serum_phospholipids serum_phospholipids 0.628 0.119 no no no no no up 16:0/22:6-PE+blood 20:2-LPC+blood 0 0 -0.460512821 serum_phospholipids serum_phospholipids 0.000934 0.119 up up no no no up 16:1/18:2-PG+blood 20:2-LPC+blood 0.571428571 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.119 no up up no no up 18:0-LPC+blood 20:2-LPC+blood 0 0 0.45025641 serum_phospholipids serum_phospholipids 0.554 0.119 no no no no no up 18:0/18:0-PC+blood 20:2-LPC+blood 0 0 0.417435897 serum_phospholipids serum_phospholipids 0.426 0.119 no no no no no up 18:0/18:0-PE+blood 20:2-LPC+blood -0.511278195 -0.482843137 0 serum_phospholipids serum_phospholipids 0.00896 0.119 up up no no no up 18:0/18:0-PS+blood 20:2-LPC+blood 0 0 -0.608205128 serum_phospholipids serum_phospholipids 0.00617 0.119 no up no no no up 18:0/18:1-PC+blood 20:2-LPC+blood 0 0 0.404444444 serum_phospholipids serum_phospholipids 0.393 0.119 no no no no no up 18:0/18:1-PE+blood 20:2-LPC+blood -0.485714286 0 0 serum_phospholipids serum_phospholipids 0.00716 0.119 up up no no no up 18:0/18:1-PG+blood 20:2-LPC+blood 0 0 -0.617777778 serum_phospholipids serum_phospholipids 0.000842 0.119 no up no no no up 18:0/18:2-PC+blood 20:2-LPC+blood 0 0 0.634188034 serum_phospholipids serum_phospholipids 1.74E-06 0.119 no up up no no up 18:0/20:2-PC+blood 20:2-LPC+blood 0 0 0.552820513 serum_phospholipids serum_phospholipids 0.733 0.119 no no no no no up 18:0/20:3-PC+blood 20:2-LPC+blood 0 0 0.509059829 serum_phospholipids serum_phospholipids 0.0682 0.119 no up no no no up 18:0/20:3-PI+blood 20:2-LPC+blood 0.678195489 0 0 serum_phospholipids serum_phospholipids 0.377 0.119 no no no no no up 18:0/20:5-PC+blood 20:2-LPC+blood 0 0 0.408547009 serum_phospholipids serum_phospholipids 0.17 0.119 no no no no no up 18:1-LPC+blood 20:2-LPC+blood 0.645112782 0 0 serum_phospholipids serum_phospholipids 0.179 0.119 no no no no no up 18:1/16:0-PE+blood 20:2-LPC+blood 0 0 -0.457094017 serum_phospholipids serum_phospholipids 0.000182 0.119 up up no no no up 18:1/16:1-PE+blood 20:2-LPC+blood 0 0 -0.415384615 serum_phospholipids serum_phospholipids 0.000184 0.119 up up no no no up 18:1/18:0-PC+blood 20:2-LPC+blood 0 0 0.63965812 serum_phospholipids serum_phospholipids 1.83E-06 0.119 no up up no no up 18:1/18:0-PE+blood 20:2-LPC+blood 0 0 -0.495384615 serum_phospholipids serum_phospholipids 1.39E-06 0.119 up up no no no up 18:1/18:1-PC+blood 20:2-LPC+blood 0.657142857 0 0.55008547 serum_phospholipids serum_phospholipids 1.34E-05 0.119 no up up no no up 18:1/18:1-PE+blood 20:2-LPC+blood 0 0 -0.488547009 serum_phospholipids serum_phospholipids 1.03E-05 0.119 up up no no no up 18:1/18:2-PE+blood 20:2-LPC+blood 0 0 -0.478974359 serum_phospholipids serum_phospholipids 0.000293 0.119 up up no no no up 18:1/18:2-PG+blood 20:2-LPC+blood 0.544360902 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.119 no up up no no up 18:1/18:2-PI+blood 20:2-LPC+blood 0.479699248 0 0 serum_phospholipids serum_phospholipids 0.0164 0.119 dn no up no no up 18:1/20:3-PC+blood 20:2-LPC+blood 0.536842105 0.691176471 0.708717949 serum_phospholipids serum_phospholipids 0.00872 0.119 no up up no no up 18:1/20:4-PE+blood 20:2-LPC+blood 0 0 -0.418803419 serum_phospholipids serum_phospholipids 0.0578 0.119 up no no no no up 18:2-LPA+blood 20:2-LPC+blood 0.490225564 0 0 serum_phospholipids serum_phospholipids 0.00684 0.119 dn no up no no up 18:2/16:0-PC+blood 20:2-LPC+blood 0.482706767 0 0.508376068 serum_phospholipids serum_phospholipids 8.67E-05 0.119 no up up no no up 18:2/18:1-PC+blood 20:2-LPC+blood 0.603007519 0 0.558290598 serum_phospholipids serum_phospholipids 2.30E-05 0.119 dn up up no no up 18:2/18:2-PC+blood 20:2-LPC+blood 0.530827068 0 0.545982906 serum_phospholipids serum_phospholipids 1.98E-05 0.119 dn up up no no up 18:2/18:2-PS+blood 20:2-LPC+blood 0 0 -0.416752137 serum_phospholipids serum_phospholipids 0.00674 0.119 up up no no no up 18:2n6c+blood 20:2-LPC+blood 0 0 0.427008547 serum_fattyacid serum_phospholipids 0.15 0.119 no no no no no up 20:0-LPC+blood 20:2-LPC+blood 0 0.612745098 0 serum_phospholipids serum_phospholipids 0.199 0.119 no no no no no up 20:0-LPE+blood 20:2-LPC+blood 0 0 0.405811966 serum_phospholipids serum_phospholipids 0.0615 0.119 no no up no no up 20:0+blood 20:2-LPC+blood 0 0.553921569 0 yes serum_fattyacid serum_phospholipids 0.000278 0.119 dn no up no no up 20:1-LPC+blood 20:2-LPC+blood 0 0.698529412 0.55965812 serum_phospholipids serum_phospholipids 0.217 0.119 no no no no no up 20:1-LPE+blood 20:2-LPC+blood 0 0.710784314 0 serum_phospholipids serum_phospholipids 0.465 0.119 no no no no no up 20:2+blood 20:2-LPC+blood 0.726315789 0 0.633504274 serum_fattyacid serum_phospholipids 0.478 0.119 no no no no no up 13-HODE+blood 20:2-LPE+blood 0 0.50245098 0 serum_ARA serum_phospholipids 0.32 0.177 no no no no no no 16:0/18:0-PC+blood 20:2-LPE+blood 0 0 0.431794872 serum_phospholipids serum_phospholipids 0.521 0.177 no no no no no no 18:0/18:2-PC+blood 20:2-LPE+blood 0 0 0.433162393 serum_phospholipids serum_phospholipids 1.74E-06 0.177 no up up no no no 18:1/18:0-PC+blood 20:2-LPE+blood 0 0 0.457094017 serum_phospholipids serum_phospholipids 1.83E-06 0.177 no up up no no no 18:2/18:1-PC+blood 20:2-LPE+blood 0 0 0.596581197 serum_phospholipids serum_phospholipids 2.30E-05 0.177 dn up up no no no 18:2/18:2-PC+blood 20:2-LPE+blood 0 0 0.616410256 serum_phospholipids serum_phospholipids 1.98E-05 0.177 dn up up no no no 18:2/20:4-PC+blood 20:2-LPE+blood 0 0 0.423589744 serum_phospholipids serum_phospholipids 0.0145 0.177 no no up no no no 18:3/18:2-PC+blood 20:2-LPE+blood 0 0 0.427008547 serum_phospholipids serum_phospholipids 0.0394 0.177 no no up no no no 20:0+blood 20:2-LPE+blood 0.485714286 0.580882353 0 yes serum_fattyacid serum_phospholipids 0.000278 0.177 dn no up no no no 20:1-LPC+blood 20:2-LPE+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.217 0.177 no no no no no no 20:1-LPE+blood 20:2-LPE+blood 0.566917293 0.742647059 0.582905983 serum_phospholipids serum_phospholipids 0.465 0.177 no no no no no no 20:2-LPC+blood 20:2-LPE+blood 0 0.737745098 0.526153846 serum_phospholipids serum_phospholipids 0.119 0.177 no no up no no no "12,13-EPOME+blood" 20:2/18:0-PC+blood 0 0 -0.481943192 serum_ARA serum_phospholipids 0.901 0.0427 no no no no up no 14:0-LPC+blood 20:2/18:0-PC+blood 0.467669173 0 0 serum_phospholipids serum_phospholipids 0.00689 0.0427 up up no no up no 14:0/16:0-PC+blood 20:2/18:0-PC+blood 0 0 0.464615385 serum_phospholipids serum_phospholipids 0.0358 0.0427 no up no no up no 14:0/18:0-PC+blood 20:2/18:0-PC+blood 0 0.693627451 0 serum_phospholipids serum_phospholipids 0.00289 0.0427 up up no no up no 14:0/18:2-PC+blood 20:2/18:0-PC+blood 0.690225564 0 0 serum_phospholipids serum_phospholipids 0.102 0.0427 no up no no up no 14:0/20:4-PC+blood 20:2/18:0-PC+blood 0.721804511 0 0 serum_phospholipids serum_phospholipids 0.486 0.0427 no no no no up no 16:0/16:1-PC+blood 20:2/18:0-PC+blood 0 0.715686275 0 serum_phospholipids serum_phospholipids 0.00283 0.0427 up up no no up no 16:0/16:1-PI+blood 20:2/18:0-PC+blood 0 0.779411765 0.412649573 serum_phospholipids serum_phospholipids 0.262 0.0427 no no no no up no 16:0/18:2-PI+blood 20:2/18:0-PC+blood 0 0.49754902 0 serum_phospholipids serum_phospholipids 0.269 0.0427 no no no no up no 16:0/20:3-PC+blood 20:2/18:0-PC+blood 0 0.578431373 0.722393162 serum_phospholipids serum_phospholipids 5.43E-06 0.0427 no up up no up no 16:0/20:4-PI+blood 20:2/18:0-PC+blood 0 0.549019608 0.416068376 serum_phospholipids serum_phospholipids 0.558 0.0427 no no no no up no 16:1/18:1-PG+blood 20:2/18:0-PC+blood 0 0.49754902 0 serum_phospholipids serum_phospholipids 3.21E-05 0.0427 no up up no up no 18:0/18:0-PC+blood 20:2/18:0-PC+blood 0 0.855392157 0.496752137 serum_phospholipids serum_phospholipids 0.426 0.0427 no no no no up no 18:0/18:1-PC+blood 20:2/18:0-PC+blood 0 0.860294118 0.47965812 serum_phospholipids serum_phospholipids 0.393 0.0427 no no no no up no 18:0/18:1-PI+blood 20:2/18:0-PC+blood 0 0.553921569 0 serum_phospholipids serum_phospholipids 0.599 0.0427 no no no no up no 18:0/20:2-PC+blood 20:2/18:0-PC+blood 0.536842105 0.843137255 0.45982906 serum_phospholipids serum_phospholipids 0.733 0.0427 no no no no up no 18:0/20:3-PC+blood 20:2/18:0-PC+blood 0.983458647 0.99754902 0.992478632 serum_phospholipids serum_phospholipids 0.0682 0.0427 no up no no up no 18:0/20:3-PI+blood 20:2/18:0-PC+blood 0 0.620098039 0 serum_phospholipids serum_phospholipids 0.377 0.0427 no no no no up no 18:0/20:5-PC+blood 20:2/18:0-PC+blood 0 -0.490196078 0 serum_phospholipids serum_phospholipids 0.17 0.0427 no no no no up no 18:0+blood 20:2/18:0-PC+blood 0.584962406 0 0 serum_fattyacid serum_phospholipids 0.344 0.0427 no no no no up no 18:1/18:1-PC+blood 20:2/18:0-PC+blood 0 0.632352941 0.708717949 serum_phospholipids serum_phospholipids 1.34E-05 0.0427 no up up no up no 18:1/18:1-PG+blood 20:2/18:0-PC+blood 0 0.715686275 0 serum_phospholipids serum_phospholipids 0.00352 0.0427 no up up no up no 18:1/20:3-PC+blood 20:2/18:0-PC+blood 0 0.558823529 0.706666667 serum_phospholipids serum_phospholipids 0.00872 0.0427 no up up no up no 18:2-LPC+blood 20:2/18:0-PC+blood 0 -0.632352941 0 serum_phospholipids serum_phospholipids 0.00743 0.0427 dn no up no up no 18:2/16:0-PC+blood 20:2/18:0-PC+blood 0 -0.551470588 0 serum_phospholipids serum_phospholipids 8.67E-05 0.0427 no up up no up no 18:3-LPC+blood 20:2/18:0-PC+blood 0 -0.705882353 0 serum_phospholipids serum_phospholipids 0.147 0.0427 no no no no up no 18:3n3+blood 20:2/18:0-PC+blood 0 -0.762254902 0 serum_fattyacid serum_phospholipids 0.291 0.0427 no no no no up no 18:3n6+blood 20:2/18:0-PC+blood 0.481203008 0 0 serum_fattyacid serum_phospholipids 0.0463 0.0427 up no dn no up no 20:0+blood 20:2/18:0-PC+blood 0 0 0.412649573 yes serum_fattyacid serum_phospholipids 0.000278 0.0427 dn no up no up no 20:2-LPC+blood 20:2/18:0-PC+blood 0 0 0.496068376 serum_phospholipids serum_phospholipids 0.119 0.0427 no no up no up no 3-(3-Hydroxyphenyl)propanoic acid+stool 20:2/18:0-PC+blood 0.642857143 0 0 stool_cometabolism serum_phospholipids 0.33 0.0427 no no no no up no Adipocytokine signaling pathway 20:2/18:0-PC+blood 0 0 0.550769231 kegg serum_phospholipids NA 0.0427 no no no no up no AMPK signaling pathway 20:2/18:0-PC+blood 0 0 0.413846154 kegg serum_phospholipids NA 0.0427 no no no no up no Arachidonic acid metabolism 20:2/18:0-PC+blood 0 0 0.429230769 kegg serum_phospholipids NA 0.0427 no no no no up no Biosynthesis of cofactors 20:2/18:0-PC+blood 0 0 0.425384615 kegg serum_phospholipids NA 0.0427 no no no no up no Central carbon metabolism in cancer 20:2/18:0-PC+blood 0 0 -0.483846154 kegg serum_phospholipids NA 0.0427 no no no no up no Clostridium 20:2/18:0-PC+blood 0.500188076 0.562844986 0 Genus serum_phospholipids 0.925 0.0427 no no no no up no Colorectal cancer 20:2/18:0-PC+blood 0 0 -0.407692308 kegg serum_phospholipids NA 0.0427 no no no no up no Ferroptosis 20:2/18:0-PC+blood 0 0 0.55 kegg serum_phospholipids NA 0.0427 no no no no up no FoxO signaling pathway 20:2/18:0-PC+blood 0 0 -0.633846154 kegg serum_phospholipids NA 0.0427 no no no no up no Gastric cancer 20:2/18:0-PC+blood 0 0 -0.406923077 kegg serum_phospholipids NA 0.0427 no no no no up no Glioma 20:2/18:0-PC+blood 0 0 -0.436923077 kegg serum_phospholipids NA 0.0427 no no no no up no Glutathione metabolism 20:2/18:0-PC+blood 0 0 0.520769231 kegg serum_phospholipids NA 0.0427 no no no no up no "Glycine, serine and threonine metabolism" 20:2/18:0-PC+blood 0 0 0.462307692 kegg serum_phospholipids NA 0.0427 no up no no up no HDCA+stool 20:2/18:0-PC+blood 0 0 -0.490225564 stool_bileacids serum_phospholipids 0.176 0.0427 no no no no up no Kaposi sarcoma-associated herpesvirus infection 20:2/18:0-PC+blood 0 0 0.623846154 kegg serum_phospholipids NA 0.0427 no no dn no up no Longevity regulating pathway 20:2/18:0-PC+blood 0 0 0.446923077 kegg serum_phospholipids NA 0.0427 no no no no up no Malaria 20:2/18:0-PC+blood 0 0 0.401538462 kegg serum_phospholipids NA 0.0427 no no no no up no Mineral absorption 20:2/18:0-PC+blood 0 0 0.49 kegg serum_phospholipids NA 0.0427 no no no no up no Mitophagy - animal 20:2/18:0-PC+blood 0 0 0.441538462 kegg serum_phospholipids NA 0.0427 no no no no up no Necroptosis 20:2/18:0-PC+blood 0 0 0.426923077 kegg serum_phospholipids NA 0.0427 no no no no up no NOD-like receptor signaling pathway 20:2/18:0-PC+blood 0 -0.523529412 0 kegg serum_phospholipids NA 0.0427 no no no no up no nutriCA+stool 20:2/18:0-PC+blood 0 0.834897522 0 stool_bileacids serum_phospholipids 0.481 0.0427 no no no no up no Oocyte meiosis 20:2/18:0-PC+blood 0 0 -0.48 kegg serum_phospholipids NA 0.0427 no no no no up no Pathways of neurodegeneration - multiple diseases 20:2/18:0-PC+blood 0 0 0.467692308 kegg serum_phospholipids NA 0.0427 no no no no up no Phosphatidylinositol signaling system 20:2/18:0-PC+blood 0 0 -0.474615385 kegg serum_phospholipids NA 0.0427 no no no no up no Platinum drug resistance 20:2/18:0-PC+blood 0 0 -0.47 kegg serum_phospholipids NA 0.0427 no no no no up no Porphyrin and chlorophyll metabolism 20:2/18:0-PC+blood 0 0 0.493076923 kegg serum_phospholipids NA 0.0427 no no no no up no Primary immunodeficiency 20:2/18:0-PC+blood 0 0 -0.480769231 kegg serum_phospholipids NA 0.0427 no no no no up no Progesterone-mediated oocyte maturation 20:2/18:0-PC+blood 0 0 -0.504615385 kegg serum_phospholipids NA 0.0427 no no no no up no Purine metabolism 20:2/18:0-PC+blood 0 0 0.426923077 kegg serum_phospholipids NA 0.0427 no no no no up no Ruminococcus 20:2/18:0-PC+blood 0 0.615196078 0 acetate-producing Genus serum_phospholipids 0.335 0.0427 no no no no up no Shigellosis 20:2/18:0-PC+blood 0 0 0.476923077 kegg serum_phospholipids NA 0.0427 no no no no up no Sphingolipid signaling pathway 20:2/18:0-PC+blood 0 0 -0.515384615 kegg serum_phospholipids NA 0.0427 no no no no up no Spinocerebellar ataxia 20:2/18:0-PC+blood 0 0 -0.456153846 kegg serum_phospholipids NA 0.0427 no no no no up no Thyroid hormone synthesis 20:2/18:0-PC+blood 0 0 0.476923077 kegg serum_phospholipids NA 0.0427 no no no no up no Ubiquitin mediated proteolysis 20:2/18:0-PC+blood 0 0 0.421538462 kegg serum_phospholipids NA 0.0427 no no no no up no 11-HETE+blood 20:2/18:1-PE+blood 0 0.547766103 0 serum_ARA serum_phospholipids 0.464 0.00208 no no no up up no 14:0/16:0-PC+blood 20:2/18:1-PE+blood 0 0 0.417435897 serum_phospholipids serum_phospholipids 0.0358 0.00208 no up no up up no 14:0/18:0-PC+blood 20:2/18:1-PE+blood 0 0.644607843 0 serum_phospholipids serum_phospholipids 0.00289 0.00208 up up no up up no 16:0-LPE+blood 20:2/18:1-PE+blood 0 0 0.436581197 serum_phospholipids serum_phospholipids 0.0711 0.00208 up up no up up no 16:0/14:0-PC+blood 20:2/18:1-PE+blood -0.454135338 0 -0.48991453 serum_phospholipids serum_phospholipids 0.0206 0.00208 no up up up up no 16:0/16:0-PI+blood 20:2/18:1-PE+blood 0.473684211 0 0 serum_phospholipids serum_phospholipids 0.358 0.00208 no no no up up no 16:0/16:1-PC+blood 20:2/18:1-PE+blood 0 0.671568627 0.402393162 serum_phospholipids serum_phospholipids 0.00283 0.00208 up up no up up no 16:0/16:1-PI+blood 20:2/18:1-PE+blood 0 0.595588235 0.410598291 serum_phospholipids serum_phospholipids 0.262 0.00208 no no no up up no 16:0/18:0-PS+blood 20:2/18:1-PE+blood 0.777443609 0 0.481709402 serum_phospholipids serum_phospholipids 0.377 0.00208 no no no up up no 16:0/18:1-PC+blood 20:2/18:1-PE+blood -0.503759398 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.00208 up up up up up no 16:0/18:1-PE+blood 20:2/18:1-PE+blood 0.795488722 0.757352941 0.653333333 serum_phospholipids serum_phospholipids 0.000107 0.00208 up up no up up no 16:0/18:2-PC+blood 20:2/18:1-PE+blood -0.639097744 0 0 serum_phospholipids serum_phospholipids 3.24E-06 0.00208 no up up up up no 16:0/18:2-PI+blood 20:2/18:1-PE+blood 0 0.774509804 0 serum_phospholipids serum_phospholipids 0.269 0.00208 no no no up up no 16:0/20:4-PC+blood 20:2/18:1-PE+blood -0.562406015 -0.674019608 0 serum_phospholipids serum_phospholipids 0.0262 0.00208 no up no up up no 16:0/20:4-PE+blood 20:2/18:1-PE+blood 0.609022556 0.585784314 0.569230769 serum_phospholipids serum_phospholipids 0.00139 0.00208 up up no up up no 16:0/20:4-PI+blood 20:2/18:1-PE+blood 0 0.517156863 0.450940171 serum_phospholipids serum_phospholipids 0.558 0.00208 no no no up up no 16:0/22:6-PC+blood 20:2/18:1-PE+blood 0 -0.568627451 0 serum_phospholipids serum_phospholipids 4.53E-05 0.00208 no up up up up no 16:0/22:6-PE+blood 20:2/18:1-PE+blood 0.795488722 0.5 0.69025641 serum_phospholipids serum_phospholipids 0.000934 0.00208 up up no up up no 18:0-LPE+blood 20:2/18:1-PE+blood 0.615037594 0 0.481709402 serum_phospholipids serum_phospholipids 0.491 0.00208 no no no up up no 18:0/16:0-PC+blood 20:2/18:1-PE+blood -0.47518797 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.00208 up up up up up no 18:0/18:0-PE+blood 20:2/18:1-PE+blood 0.721804511 0.661764706 0.651965812 serum_phospholipids serum_phospholipids 0.00896 0.00208 up up no up up no 18:0/18:0-PS+blood 20:2/18:1-PE+blood 0.660150376 0.495098039 0.432478632 serum_phospholipids serum_phospholipids 0.00617 0.00208 no up no up up no 18:0/18:1-PE+blood 20:2/18:1-PE+blood 0.714285714 0.74754902 0.622564103 serum_phospholipids serum_phospholipids 0.00716 0.00208 up up no up up no 18:0/18:1-PG+blood 20:2/18:1-PE+blood 0.50075188 0.625 0.461880342 serum_phospholipids serum_phospholipids 0.000842 0.00208 no up no up up no 18:0/18:1-PI+blood 20:2/18:1-PE+blood 0 0.519607843 0 serum_phospholipids serum_phospholipids 0.599 0.00208 no no no up up no 18:0/18:2-PI+blood 20:2/18:1-PE+blood 0.589473684 0 0 serum_phospholipids serum_phospholipids 0.179 0.00208 no no no up up no 18:0/20:3-PC+blood 20:2/18:1-PE+blood 0 0.585784314 0.471452991 serum_phospholipids serum_phospholipids 0.0682 0.00208 no up no up up no 18:0/20:3-PI+blood 20:2/18:1-PE+blood 0 0.492647059 0 serum_phospholipids serum_phospholipids 0.377 0.00208 no no no up up no 18:0/20:4-PC+blood 20:2/18:1-PE+blood -0.487218045 -0.666666667 0 serum_phospholipids serum_phospholipids 0.454 0.00208 no no no up up no 18:0/20:5-PC+blood 20:2/18:1-PE+blood 0 -0.68872549 0 serum_phospholipids serum_phospholipids 0.17 0.00208 no no no up up no 18:0/22:6-PE+blood 20:2/18:1-PE+blood 0.681203008 0 0.520683761 serum_phospholipids serum_phospholipids 0.00022 0.00208 up up no up up no 18:1/16:0-PC+blood 20:2/18:1-PE+blood -0.654135338 0 0 serum_phospholipids serum_phospholipids 2.43E-05 0.00208 no up up up up no 18:1/16:0-PE+blood 20:2/18:1-PE+blood 0.70075188 0.705882353 0.76 serum_phospholipids serum_phospholipids 0.000182 0.00208 up up no up up no 18:1/16:0-PI+blood 20:2/18:1-PE+blood 0 0.509803922 0 serum_phospholipids serum_phospholipids 0.793 0.00208 no no no up up no 18:1/16:1-PE+blood 20:2/18:1-PE+blood 0.759398496 0.774509804 0.593846154 serum_phospholipids serum_phospholipids 0.000184 0.00208 up up no up up no 18:1/18:0-PE+blood 20:2/18:1-PE+blood 0.769924812 0.828431373 0.738803419 serum_phospholipids serum_phospholipids 1.39E-06 0.00208 up up no up up no 18:1/18:1-PE+blood 20:2/18:1-PE+blood 0.864661654 0.865196078 0.778461538 serum_phospholipids serum_phospholipids 1.03E-05 0.00208 up up no up up no 18:1/18:1-PG+blood 20:2/18:1-PE+blood 0 0.598039216 0 serum_phospholipids serum_phospholipids 0.00352 0.00208 no up up up up no 18:1/18:2-PE+blood 20:2/18:1-PE+blood 0.708270677 0.796568627 0.584957265 serum_phospholipids serum_phospholipids 0.000293 0.00208 up up no up up no 18:1/20:4-PC+blood 20:2/18:1-PE+blood 0 -0.578431373 0 serum_phospholipids serum_phospholipids 0.582 0.00208 no no no up up no 18:1/20:4-PE+blood 20:2/18:1-PE+blood 0.687218045 0.519607843 0.622564103 serum_phospholipids serum_phospholipids 0.0578 0.00208 up no no up up no 18:1/22:6-PE+blood 20:2/18:1-PE+blood 0.493233083 0 0 serum_phospholipids serum_phospholipids 0.0047 0.00208 no up no up up no 18:2-LPC+blood 20:2/18:1-PE+blood 0 0 -0.446837607 serum_phospholipids serum_phospholipids 0.00743 0.00208 dn no up up up no 18:2/18:2-PS+blood 20:2/18:1-PE+blood 0.691729323 0.708333333 0 serum_phospholipids serum_phospholipids 0.00674 0.00208 up up no up up no 18:3/16:0-PE+blood 20:2/18:1-PE+blood 0.822556391 0.661764706 0.61025641 serum_phospholipids serum_phospholipids 0.00149 0.00208 up up no up up no 18:3/18:2-PC+blood 20:2/18:1-PE+blood 0.457142857 0 0 serum_phospholipids serum_phospholipids 0.0394 0.00208 no no up up up no 20:0/20:4-PE+blood 20:2/18:1-PE+blood 0.636090226 0.671568627 0.803760684 serum_phospholipids serum_phospholipids 0.00128 0.00208 up up no up up no 20:1/20:4-PE+blood 20:2/18:1-PE+blood 0.52481203 0.666666667 0.771623932 serum_phospholipids serum_phospholipids 0.0042 0.00208 up up no up up no 20:2/18:0-PC+blood 20:2/18:1-PE+blood 0 0.578431373 0.483076923 serum_phospholipids serum_phospholipids 0.0427 0.00208 no up no up up no 14:0-LPC+blood 20:2/18:3-PE+blood -0.627067669 0 0 serum_phospholipids serum_phospholipids 0.00689 0.0391 up up no up up no 14:1/18:2-PG+blood 20:2/18:3-PE+blood -0.630075188 0 0 serum_phospholipids serum_phospholipids 0.00259 0.0391 no up up up up no 16:0/18:0-PS+blood 20:2/18:3-PE+blood 0.520300752 0.571078431 0 serum_phospholipids serum_phospholipids 0.377 0.0391 no no no up up no 16:0/18:1-PE+blood 20:2/18:3-PE+blood 0 0 0.488547009 serum_phospholipids serum_phospholipids 0.000107 0.0391 up up no up up no 16:0/20:4-PC+blood 20:2/18:3-PE+blood 0 0 0.433846154 serum_phospholipids serum_phospholipids 0.0262 0.0391 no up no up up no 16:0/20:4-PE+blood 20:2/18:3-PE+blood 0.535338346 0.632352941 0.675213675 serum_phospholipids serum_phospholipids 0.00139 0.0391 up up no up up no 16:0/20:5-PG+blood 20:2/18:3-PE+blood 0.559398496 0 0 serum_phospholipids serum_phospholipids 0.00656 0.0391 no up no up up no 16:0/22:6-PE+blood 20:2/18:3-PE+blood 0.559398496 0.691176471 0.592478632 serum_phospholipids serum_phospholipids 0.000934 0.0391 up up no up up no 16:1+blood 20:2/18:3-PE+blood 0 0.551470588 0 yes serum_fattyacid serum_phospholipids 0.0186 0.0391 no no dn up up no 18:0/20:4-PC+blood 20:2/18:3-PE+blood 0 0 0.490598291 serum_phospholipids serum_phospholipids 0.454 0.0391 no no no up up no 18:0/20:4-PI+blood 20:2/18:3-PE+blood 0 0.639705882 0 serum_phospholipids serum_phospholipids 0.167 0.0391 no no no up up no 18:0/22:6-PC+blood 20:2/18:3-PE+blood -0.521804511 0 0 serum_phospholipids serum_phospholipids 0.0775 0.0391 no no up up up no 18:0/22:6-PE+blood 20:2/18:3-PE+blood 0 0 0.515897436 serum_phospholipids serum_phospholipids 0.00022 0.0391 up up no up up no 18:1/16:0-PE+blood 20:2/18:3-PE+blood 0.488721805 0 0.530940171 serum_phospholipids serum_phospholipids 0.000182 0.0391 up up no up up no 18:1/16:1-PE+blood 20:2/18:3-PE+blood 0 0 0.455726496 serum_phospholipids serum_phospholipids 0.000184 0.0391 up up no up up no 18:1/18:0-PE+blood 20:2/18:3-PE+blood 0 0 0.541196581 serum_phospholipids serum_phospholipids 1.39E-06 0.0391 up up no up up no 18:1/18:0-PS+blood 20:2/18:3-PE+blood 0 0.531862745 0 serum_phospholipids serum_phospholipids 0.193 0.0391 no no no up up no 18:1/18:1-PE+blood 20:2/18:3-PE+blood 0 0 0.537094017 serum_phospholipids serum_phospholipids 1.03E-05 0.0391 up up no up up no 18:1/18:2-PE+blood 20:2/18:3-PE+blood 0.539849624 0 0.587008547 serum_phospholipids serum_phospholipids 0.000293 0.0391 up up no up up no 18:1/20:4-PC+blood 20:2/18:3-PE+blood 0 0 0.494017094 serum_phospholipids serum_phospholipids 0.582 0.0391 no no no up up no 18:1/20:4-PE+blood 20:2/18:3-PE+blood 0.741353383 0.759803922 0.805811966 serum_phospholipids serum_phospholipids 0.0578 0.0391 up no no up up no 18:1/22:6-PE+blood 20:2/18:3-PE+blood 0.642105263 0.512254902 0.417435897 serum_phospholipids serum_phospholipids 0.0047 0.0391 no up no up up no 18:1+blood 20:2/18:3-PE+blood 0 0.578431373 0 yes serum_fattyacid serum_phospholipids 0.00202 0.0391 up no dn up up no 18:2/20:4-PC+blood 20:2/18:3-PE+blood 0 0 0.550769231 serum_phospholipids serum_phospholipids 0.0145 0.0391 no no up up up no 18:3-LPC+blood 20:2/18:3-PE+blood 0 0 -0.476923077 serum_phospholipids serum_phospholipids 0.147 0.0391 no no no up up no 20:0/20:4-PE+blood 20:2/18:3-PE+blood 0.763909774 0 0.613675214 serum_phospholipids serum_phospholipids 0.00128 0.0391 up up no up up no 20:0/20:5-PC+blood 20:2/18:3-PE+blood 0 0 0.40991453 serum_phospholipids serum_phospholipids 0.882 0.0391 no no no up up no 20:1/20:4-PC+blood 20:2/18:3-PE+blood -0.529323308 0 0 serum_phospholipids serum_phospholipids 0.0419 0.0391 no no up up up no 20:1/20:4-PE+blood 20:2/18:3-PE+blood 0.757894737 0 0.629401709 serum_phospholipids serum_phospholipids 0.0042 0.0391 up up no up up no 20:2/18:1-PE+blood 20:2/18:3-PE+blood 0.454135338 0 0.53025641 serum_phospholipids serum_phospholipids 0.00208 0.0391 up up no up up no 13-HODE+blood 20:2+blood 0.448120301 0 0 serum_ARA serum_fattyacid 0.32 0.478 no no no no no no 14:1/18:2-PG+blood 20:2+blood 0 0.632352941 0 serum_phospholipids serum_fattyacid 0.00259 0.478 no up up no no no 16:0-LPC+blood 20:2+blood 0.508270677 0 0 serum_phospholipids serum_fattyacid 0.00456 0.478 up up no no no no 16:0/14:0-PC+blood 20:2+blood 0 0.50245098 0 serum_phospholipids serum_fattyacid 0.0206 0.478 no up up no no no 16:0/18:2-PC+blood 20:2+blood 0 0.485294118 0 serum_phospholipids serum_fattyacid 3.24E-06 0.478 no up up no no no 16:0/20:3-PC+blood 20:2+blood 0.454135338 0.617647059 0.457094017 serum_phospholipids serum_fattyacid 5.43E-06 0.478 no up up no no no 16:0/20:5-PC+blood 20:2+blood -0.693233083 0 -0.43042735 serum_phospholipids serum_fattyacid 0.628 0.478 no no no no no no 16:1/18:2-PG+blood 20:2+blood 0.460150376 0.578431373 0 serum_phospholipids serum_fattyacid 1.40E-08 0.478 no up up no no no 18:0/18:0-PS+blood 20:2+blood 0 0 -0.448888889 serum_phospholipids serum_fattyacid 0.00617 0.478 no up no no no no 18:0/18:1-PC+blood 20:2+blood 0 0 0.405811966 serum_phospholipids serum_fattyacid 0.393 0.478 no no no no no no 18:0/18:1-PG+blood 20:2+blood 0 0 -0.426324786 serum_phospholipids serum_fattyacid 0.000842 0.478 no up no no no no 18:0/18:2-PC+blood 20:2+blood 0 0.566176471 0 serum_phospholipids serum_fattyacid 1.74E-06 0.478 no up up no no no 18:0/18:2-PI+blood 20:2+blood 0 0.509803922 0 serum_phospholipids serum_fattyacid 0.179 0.478 no no no no no no 18:0/20:2-PC+blood 20:2+blood 0 0 0.588376068 serum_phospholipids serum_fattyacid 0.733 0.478 no no no no no no 18:0/20:3-PI+blood 20:2+blood 0.454135338 0 0 serum_phospholipids serum_fattyacid 0.377 0.478 no no no no no no 18:1-LPC+blood 20:2+blood 0.460150376 0 0.471452991 serum_phospholipids serum_fattyacid 0.179 0.478 no no no no no no 18:1/16:0-PC+blood 20:2+blood 0 0.485294118 0 serum_phospholipids serum_fattyacid 2.43E-05 0.478 no up up no no no 18:1/18:0-PC+blood 20:2+blood 0 0.583333333 0 serum_phospholipids serum_fattyacid 1.83E-06 0.478 no up up no no no 18:1/18:1-PC+blood 20:2+blood 0.454135338 0.642156863 0.472136752 serum_phospholipids serum_fattyacid 1.34E-05 0.478 no up up no no no 18:1/18:2-PG+blood 20:2+blood 0.484210526 0 0 serum_phospholipids serum_fattyacid 5.58E-07 0.478 no up up no no no 18:1/18:2-PI+blood 20:2+blood 0.458646617 0 0 serum_phospholipids serum_fattyacid 0.0164 0.478 dn no up no no no 18:1/20:3-PC+blood 20:2+blood 0.467669173 0.487745098 0.584957265 serum_phospholipids serum_fattyacid 0.00872 0.478 no up up no no no 18:2-LPC+blood 20:2+blood 0.621052632 0 0 serum_phospholipids serum_fattyacid 0.00743 0.478 dn no up no no no 18:2-LPE+blood 20:2+blood 0 0.588235294 0 serum_phospholipids serum_fattyacid 0.112 0.478 no no no no no no 18:2/18:1-PC+blood 20:2+blood 0.568421053 0 0 serum_phospholipids serum_fattyacid 2.30E-05 0.478 dn up up no no no 18:2/18:2-PC+blood 20:2+blood 0.535338346 0 0 serum_phospholipids serum_fattyacid 1.98E-05 0.478 dn up up no no no 18:2n6c+blood 20:2+blood 0.539849624 0.669117647 0.404444444 serum_fattyacid serum_fattyacid 0.15 0.478 no no no no no no 18:3/16:0-PE+blood 20:2+blood 0 0 -0.427008547 serum_phospholipids serum_fattyacid 0.00149 0.478 up up no no no no 20:0-LPE+blood 20:2+blood 0 0 0.425641026 serum_phospholipids serum_fattyacid 0.0615 0.478 no no up no no no 20:0/20:5-PC+blood 20:2+blood 0 -0.541666667 0 serum_phospholipids serum_fattyacid 0.882 0.478 no no no no no no 20:1-LPC+blood 20:2+blood 0 0 0.475555556 serum_phospholipids serum_fattyacid 0.217 0.478 no no no no no no ACA+stool 20:2+blood 0 0 0.465903824 stool_bileacids serum_fattyacid 0.417 0.478 no no no no no no Adrenergic signaling in cardiomyocytes 20:2+blood 0 0 -0.616923077 kegg serum_fattyacid NA 0.478 no no up no no no AGE-RAGE signaling pathway in diabetic complications 20:2+blood 0.471929825 0 0 kegg serum_fattyacid NA 0.478 no no no no no no Alcoholism 20:2+blood 0 0.541176471 0 kegg serum_fattyacid NA 0.478 no no no no no no Aldosterone synthesis and secretion 20:2+blood 0 0 -0.475384615 kegg serum_fattyacid NA 0.478 no up up no no no Amoebiasis 20:2+blood 0 0.564705882 0 kegg serum_fattyacid NA 0.478 no no no no no no Amphetamine addiction 20:2+blood 0 0 -0.455384615 kegg serum_fattyacid NA 0.478 no no no no no no Apoptosis 20:2+blood 0 0.629411765 0 kegg serum_fattyacid NA 0.478 no no no no no no B cell receptor signaling pathway 20:2+blood 0 0.558823529 0 kegg serum_fattyacid NA 0.478 no no no no no no Bacteroides 20:2+blood 0 -0.536764706 0 LPS-producing Genus serum_fattyacid 0.000267 0.478 dn dn up no no no Biosynthesis of cofactors 20:2+blood 0 -0.579411765 0 kegg serum_fattyacid NA 0.478 no no no no no no Calcium signaling pathway 20:2+blood 0.512280702 0 -0.410769231 kegg serum_fattyacid NA 0.478 no up up no no no cAMP signaling pathway 20:2+blood 0 0.661764706 0 yes kegg serum_fattyacid NA 0.478 no up up no no no Cell cycle 20:2+blood 0 -0.726470588 0 kegg serum_fattyacid NA 0.478 no no no no no no Cellular senescence 20:2+blood 0 0.558823529 0 kegg serum_fattyacid NA 0.478 no no no no no no cGMP-PKG signaling pathway 20:2+blood 0 0.55 0 kegg serum_fattyacid NA 0.478 no no no no no no Chagas disease 20:2+blood 0 0.602941176 0 kegg serum_fattyacid NA 0.478 no no no no no no Chemokine signaling pathway 20:2+blood 0 0.667647059 0 kegg serum_fattyacid NA 0.478 no no no no no no Colorectal cancer 20:2+blood 0.485964912 0 -0.473076923 kegg serum_fattyacid NA 0.478 no no no no no no Cushing syndrome 20:2+blood 0 0 -0.468461538 kegg serum_fattyacid NA 0.478 no no up no no no Dopaminergic synapse 20:2+blood 0 0 -0.549230769 kegg serum_fattyacid NA 0.478 no up no no no no Epithelial cell signaling in Helicobacter pylori infection 20:2+blood 0 0.576470588 0 kegg serum_fattyacid NA 0.478 no no no no no no Epstein-Barr virus infection 20:2+blood 0 0.585294118 0 kegg serum_fattyacid NA 0.478 no no no no no no ErbB signaling pathway 20:2+blood 0.498245614 0 -0.402307692 kegg serum_fattyacid NA 0.478 no no no no no no Estrogen signaling pathway 20:2+blood 0 -0.635294118 0 kegg serum_fattyacid NA 0.478 no no no no no no Fc gamma R-mediated phagocytosis 20:2+blood 0 0 0.439230769 kegg serum_fattyacid NA 0.478 no no no no no no Glioma 20:2+blood 0.631578947 0 -0.432307692 kegg serum_fattyacid NA 0.478 no no no no no no Glucagon signaling pathway 20:2+blood 0 0 -0.610769231 kegg serum_fattyacid NA 0.478 no no no no no no "Glycine, serine and threonine metabolism" 20:2+blood 0 -0.505882353 0 kegg serum_fattyacid NA 0.478 no up no no no no GnRH signaling pathway 20:2+blood 0 0 -0.453076923 kegg serum_fattyacid NA 0.478 no no no no no no Human cytomegalovirus infection 20:2+blood 0 0.647058824 0 kegg serum_fattyacid NA 0.478 no no dn no no no Human immunodeficiency virus 1 infection 20:2+blood 0 0.602941176 0 kegg serum_fattyacid NA 0.478 no no no no no no Human papillomavirus infection 20:2+blood 0 0.544117647 0 kegg serum_fattyacid NA 0.478 no no no no no no IL-17 signaling pathway 20:2+blood 0 0.529411765 0 kegg serum_fattyacid NA 0.478 no no no no no no Inflammatory mediator regulation of TRP channels 20:2+blood 0 0 -0.499230769 kegg serum_fattyacid NA 0.478 no no no no no no Kaposi sarcoma-associated herpesvirus infection 20:2+blood 0 0.529411765 0 kegg serum_fattyacid NA 0.478 no no dn no no no Lachnospira 20:2+blood -0.479699248 0 0 butyrate-producing Genus serum_fattyacid 0.279 0.478 no no no no no no Long-term depression 20:2+blood 0 0.611764706 0 kegg serum_fattyacid NA 0.478 no no no no no no Long-term potentiation 20:2+blood 0.58245614 -0.626470588 -0.463846154 kegg serum_fattyacid NA 0.478 no no up no no no Lysosome 20:2+blood 0 0 0.433846154 kegg serum_fattyacid NA 0.478 no no no no no no MAPK signaling pathway 20:2+blood 0 -0.502941176 0 kegg serum_fattyacid NA 0.478 no no no no no no Melanogenesis 20:2+blood 0 0 -0.412307692 kegg serum_fattyacid NA 0.478 no no no no no no mRNA surveillance pathway 20:2+blood 0 -0.508823529 -0.516153846 kegg serum_fattyacid NA 0.478 no no no no no no Natural killer cell mediated cytotoxicity 20:2+blood 0 0.5 0 kegg serum_fattyacid NA 0.478 no no no no no no Neurotrophin signaling pathway 20:2+blood 0 0.535294118 0 kegg serum_fattyacid NA 0.478 no no no no no no Oocyte meiosis 20:2+blood 0 -0.6 0 kegg serum_fattyacid NA 0.478 no no no no no no Osteoclast differentiation 20:2+blood 0 0.520588235 0 kegg serum_fattyacid NA 0.478 no no no no no no Pancreatic cancer 20:2+blood 0.543859649 0 0 kegg serum_fattyacid NA 0.478 no no no no no no Pathogenic Escherichia coli infection 20:2+blood 0 0.520588235 0 kegg serum_fattyacid NA 0.478 no no no no no no Phosphatidylinositol signaling system 20:2+blood 0.540350877 0 -0.463076923 kegg serum_fattyacid NA 0.478 no no no no no no Primary immunodeficiency 20:2+blood 0 -0.752941176 0 kegg serum_fattyacid NA 0.478 no no no no no no Progesterone-mediated oocyte maturation 20:2+blood 0 -0.588235294 0 kegg serum_fattyacid NA 0.478 no no no no no no Prolactin signaling pathway 20:2+blood 0 0.5 0 kegg serum_fattyacid NA 0.478 no no no no no no Protein processing in endoplasmic reticulum 20:2+blood 0 -0.532352941 0 kegg serum_fattyacid NA 0.478 no no no no no no Ras signaling pathway 20:2+blood 0 -0.529411765 0 yes kegg serum_fattyacid NA 0.478 no up up no no no Relaxin signaling pathway 20:2+blood 0 0.635294118 0 kegg serum_fattyacid NA 0.478 no no no no no no Renal cell carcinoma 20:2+blood 0.536842105 0 -0.406923077 kegg serum_fattyacid NA 0.478 no no no no no no Ribosome biogenesis in eukaryotes 20:2+blood 0 -0.691176471 0 kegg serum_fattyacid NA 0.478 no no no no no no RNA degradation 20:2+blood 0 0 -0.437692308 kegg serum_fattyacid NA 0.478 no no no no no no Roseburia 20:2+blood 0 0 -0.463247863 butyrate-producing Genus serum_fattyacid 0.495 0.478 no no no no no no Signaling pathways regulating pluripotency of stem cells 20:2+blood 0.515789474 0 0 kegg serum_fattyacid NA 0.478 no no no no no no Spinocerebellar ataxia 20:2+blood 0 -0.544117647 0 kegg serum_fattyacid NA 0.478 no no no no no no Spliceosome 20:2+blood 0 0 -0.451538462 kegg serum_fattyacid NA 0.478 no no no no no no Staphylococcus aureus infection 20:2+blood 0 0 0.563846154 kegg serum_fattyacid NA 0.478 up no no no no no Systemic lupus erythematosus 20:2+blood 0 0 0.452307692 kegg serum_fattyacid NA 0.478 no no no no no no TCA+stool 20:2+blood 0 0.736363636 0 stool_bileacids serum_fattyacid 0.458 0.478 no no no no no no Toll-like receptor signaling pathway 20:2+blood 0 0.55 0 yes kegg serum_fattyacid NA 0.478 no no no no no no Toxoplasmosis 20:2+blood 0 0 0.523076923 kegg serum_fattyacid NA 0.478 no no no no no no Tuberculosis 20:2+blood 0 0 0.474615385 kegg serum_fattyacid NA 0.478 no no dn no no no VEGF signaling pathway 20:2+blood 0.464912281 0 0 kegg serum_fattyacid NA 0.478 no no no no no no Viral carcinogenesis 20:2+blood 0 0.532352941 0 kegg serum_fattyacid NA 0.478 no no no no no no Viral protein interaction with cytokine and cytokine receptor 20:2+blood 0 0.641176471 0 kegg serum_fattyacid NA 0.478 no no no no no no Wnt signaling pathway 20:2+blood 0 -0.573529412 -0.51 kegg serum_fattyacid NA 0.478 no no no no no no 13-HODE+blood 20:3-LPC+blood 0.679699248 0 0 serum_ARA serum_phospholipids 0.32 0.0292 no no no no up no 14:0-LPC+blood 20:3-LPC+blood 0 0 0.519316239 serum_phospholipids serum_phospholipids 0.00689 0.0292 up up no no up no 14:0/18:0-PC+blood 20:3-LPC+blood 0 0.56372549 0.463931624 serum_phospholipids serum_phospholipids 0.00289 0.0292 up up no no up no 14:1/18:2-PG+blood 20:3-LPC+blood 0 0 0.411282051 serum_phospholipids serum_phospholipids 0.00259 0.0292 no up up no up no 16:0-LPC+blood 20:3-LPC+blood 0 0 0.526837607 serum_phospholipids serum_phospholipids 0.00456 0.0292 up up no no up no 16:0-LPE+blood 20:3-LPC+blood 0 0 0.591111111 serum_phospholipids serum_phospholipids 0.0711 0.0292 up up no no up no 16:0/16:0-PC+blood 20:3-LPC+blood -0.49924812 0 0 serum_phospholipids serum_phospholipids 0.00079 0.0292 no up up no up no 16:0/16:1-PC+blood 20:3-LPC+blood 0 0.571078431 0.465982906 serum_phospholipids serum_phospholipids 0.00283 0.0292 up up no no up no 16:0/16:1-PI+blood 20:3-LPC+blood 0 0.644607843 0.488547009 serum_phospholipids serum_phospholipids 0.262 0.0292 no no no no up no 16:0/18:0-PC+blood 20:3-LPC+blood -0.487218045 0 0 serum_phospholipids serum_phospholipids 0.521 0.0292 no no no no up no 16:0/18:2-PI+blood 20:3-LPC+blood 0 0 0.470769231 serum_phospholipids serum_phospholipids 0.269 0.0292 no no no no up no 16:0/18:3-PC+blood 20:3-LPC+blood 0 0 0.418803419 serum_phospholipids serum_phospholipids 0.00216 0.0292 no up up no up no 16:0/20:3-PC+blood 20:3-LPC+blood 0 0.534313725 0.561709402 serum_phospholipids serum_phospholipids 5.43E-06 0.0292 no up up no up no 16:0/20:4-PI+blood 20:3-LPC+blood 0 0 0.43042735 serum_phospholipids serum_phospholipids 0.558 0.0292 no no no no up no 16:0/20:5-PC+blood 20:3-LPC+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.628 0.0292 no no no no up no 16:0/22:0-PE+blood 20:3-LPC+blood -0.452631579 0 0 serum_phospholipids serum_phospholipids 0.00839 0.0292 dn no up no up no 16:0/22:6-PC+blood 20:3-LPC+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 4.53E-05 0.0292 no up up no up no 16:1/16:0-PC+blood 20:3-LPC+blood 0 0 -0.475555556 serum_phospholipids serum_phospholipids 0.0215 0.0292 no up up no up no 18:0-LPA+blood 20:3-LPC+blood 0 0 0.474188034 serum_phospholipids serum_phospholipids 0.0725 0.0292 no dn no no up no 18:0/18:1-PI+blood 20:3-LPC+blood 0 0.656862745 0 serum_phospholipids serum_phospholipids 0.599 0.0292 no no no no up no 18:0/20:2-PC+blood 20:3-LPC+blood 0 0.487745098 0 serum_phospholipids serum_phospholipids 0.733 0.0292 no no no no up no 18:0/20:3-PC+blood 20:3-LPC+blood 0 0.700980392 0.730598291 serum_phospholipids serum_phospholipids 0.0682 0.0292 no up no no up no 18:0/20:3-PI+blood 20:3-LPC+blood 0.469172932 0.661764706 0 serum_phospholipids serum_phospholipids 0.377 0.0292 no no no no up no 18:1-LPE+blood 20:3-LPC+blood 0 0 0.451623932 serum_phospholipids serum_phospholipids 0.117 0.0292 no no no no up no 18:1/18:1-PC+blood 20:3-LPC+blood 0 0.632352941 0.561709402 serum_phospholipids serum_phospholipids 1.34E-05 0.0292 no up up no up no 18:1/18:1-PI+blood 20:3-LPC+blood 0 0.625 0 serum_phospholipids serum_phospholipids 0.111 0.0292 dn no no no up no 18:1/20:3-PC+blood 20:3-LPC+blood 0 0.732843137 0.555555556 serum_phospholipids serum_phospholipids 0.00872 0.0292 no up up no up no 18:2/16:0-PC+blood 20:3-LPC+blood 0 -0.676470588 0 serum_phospholipids serum_phospholipids 8.67E-05 0.0292 no up up no up no 18:2/18:2-PS+blood 20:3-LPC+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 0.00674 0.0292 up up no no up no 18:3-LPC+blood 20:3-LPC+blood 0 -0.602941176 0 serum_phospholipids serum_phospholipids 0.147 0.0292 no no no no up no 18:3n3+blood 20:3-LPC+blood 0 -0.678921569 -0.435897436 serum_fattyacid serum_phospholipids 0.291 0.0292 no no no no up no 18:3n6+blood 20:3-LPC+blood 0 0 0.494700855 serum_fattyacid serum_phospholipids 0.0463 0.0292 up no dn no up no 20:0+blood 20:3-LPC+blood 0 0 0.494700855 yes serum_fattyacid serum_phospholipids 0.000278 0.0292 dn no up no up no 20:2/18:0-PC+blood 20:3-LPC+blood 0 0.68872549 0.745641026 serum_phospholipids serum_phospholipids 0.0427 0.0292 no up no no up no 20:2/18:1-PE+blood 20:3-LPC+blood 0 0 0.498119658 serum_phospholipids serum_phospholipids 0.00208 0.0292 up up no no up no 12-ketoDCA+blood 20:3-LPE+blood 0 0 -0.609974118 serum_bileacids serum_phospholipids 0.517 0.084 no no no no up no "12,13-EPOME+blood" 20:3-LPE+blood 0 0 -0.439407315 serum_ARA serum_phospholipids 0.901 0.084 no no no no up no 14:0/18:0-PC+blood 20:3-LPE+blood 0 0.639705882 0 serum_phospholipids serum_phospholipids 0.00289 0.084 up up no no up no 16:0-LPE+blood 20:3-LPE+blood 0 0 0.500854701 serum_phospholipids serum_phospholipids 0.0711 0.084 up up no no up no 16:0/16:1-PC+blood 20:3-LPE+blood 0 0.605392157 0 serum_phospholipids serum_phospholipids 0.00283 0.084 up up no no up no 16:0/16:1-PI+blood 20:3-LPE+blood 0 0.50245098 0 serum_phospholipids serum_phospholipids 0.262 0.084 no no no no up no 16:0/20:3-PC+blood 20:3-LPE+blood 0 0 0.528888889 serum_phospholipids serum_phospholipids 5.43E-06 0.084 no up up no up no 16:0/20:5-PC+blood 20:3-LPE+blood 0 -0.595588235 0 serum_phospholipids serum_phospholipids 0.628 0.084 no no no no up no 16:0/22:0-PE+blood 20:3-LPE+blood -0.810526316 -0.551470588 0 serum_phospholipids serum_phospholipids 0.00839 0.084 dn no up no up no 16:0/22:6-PC+blood 20:3-LPE+blood -0.57443609 -0.529411765 0 serum_phospholipids serum_phospholipids 4.53E-05 0.084 no up up no up no 16:0+blood 20:3-LPE+blood 0.523308271 0 0 yes serum_fattyacid serum_phospholipids 0.00876 0.084 up no no no up no 16:1/16:1-PC+blood 20:3-LPE+blood 0 -0.531862745 0 serum_phospholipids serum_phospholipids 0.0177 0.084 no no up no up no 18:0-LPE+blood 20:3-LPE+blood 0 0 0.448888889 serum_phospholipids serum_phospholipids 0.491 0.084 no no no no up no 18:0/20:3-PC+blood 20:3-LPE+blood 0 0 0.535042735 serum_phospholipids serum_phospholipids 0.0682 0.084 no up no no up no 18:0/20:5-PC+blood 20:3-LPE+blood -0.508270677 0 0 serum_phospholipids serum_phospholipids 0.17 0.084 no no no no up no 18:0/22:6-PC+blood 20:3-LPE+blood -0.572932331 -0.504901961 -0.478290598 serum_phospholipids serum_phospholipids 0.0775 0.084 no no up no up no 18:0/22:6-PE+blood 20:3-LPE+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.00022 0.084 up up no no up no 18:0/22:6-PI+blood 20:3-LPE+blood 0 -0.549019608 -0.445470085 serum_phospholipids serum_phospholipids 0.425 0.084 no no no no up no 18:1-LPE+blood 20:3-LPE+blood 0.520300752 0 0.549401709 serum_phospholipids serum_phospholipids 0.117 0.084 no no no no up no 18:1/18:1-PC+blood 20:3-LPE+blood 0 0.517156863 0.511794872 serum_phospholipids serum_phospholipids 1.34E-05 0.084 no up up no up no 18:1/20:3-PC+blood 20:3-LPE+blood 0 0.524509804 0.55965812 serum_phospholipids serum_phospholipids 0.00872 0.084 no up up no up no 18:1/20:4-PI+blood 20:3-LPE+blood -0.482706767 0 0 serum_phospholipids serum_phospholipids 0.192 0.084 no no no no up no 18:2-LPE+blood 20:3-LPE+blood 0 0.68627451 0 serum_phospholipids serum_phospholipids 0.112 0.084 no no no no up no 18:2/18:2-PS+blood 20:3-LPE+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.00674 0.084 up up no no up no 18:2/20:4-PC+blood 20:3-LPE+blood -0.541353383 0 0 serum_phospholipids serum_phospholipids 0.0145 0.084 no no up no up no 18:3n3+blood 20:3-LPE+blood 0 -0.698529412 0 serum_fattyacid serum_phospholipids 0.291 0.084 no no no no up no 20:0-LPC+blood 20:3-LPE+blood 0 0 0.469401709 serum_phospholipids serum_phospholipids 0.199 0.084 no no no no up no 20:0+blood 20:3-LPE+blood 0 0 0.439316239 yes serum_fattyacid serum_phospholipids 0.000278 0.084 dn no up no up no 20:1/20:4-PC+blood 20:3-LPE+blood -0.554887218 0 0 serum_phospholipids serum_phospholipids 0.0419 0.084 no no up no up no 20:2-LPC+blood 20:3-LPE+blood 0 0 0.412649573 serum_phospholipids serum_phospholipids 0.119 0.084 no no up no up no 20:2/18:0-PC+blood 20:3-LPE+blood 0 0 0.521367521 serum_phospholipids serum_phospholipids 0.0427 0.084 no up no no up no 20:3-LPC+blood 20:3-LPE+blood 0.533834586 0.524509804 0.714188034 serum_phospholipids serum_phospholipids 0.0292 0.084 no up no no up no 16:0-LPC+blood 20:3/16:0-PC+blood 0 0 -0.537777778 serum_phospholipids serum_phospholipids 0.00456 0.00405 up up no no up up 16:0-LPE+blood 20:3/16:0-PC+blood -0.583458647 0 0 serum_phospholipids serum_phospholipids 0.0711 0.00405 up up no no up up 16:0/14:0-PC+blood 20:3/16:0-PC+blood 0.705263158 0 0.623931624 serum_phospholipids serum_phospholipids 0.0206 0.00405 no up up no up up 16:0/16:0-PC+blood 20:3/16:0-PC+blood 0 0 0.436581197 serum_phospholipids serum_phospholipids 0.00079 0.00405 no up up no up up 16:0/16:0-PI+blood 20:3/16:0-PC+blood -0.657142857 -0.620098039 0 serum_phospholipids serum_phospholipids 0.358 0.00405 no no no no up up 16:0/16:1-PI+blood 20:3/16:0-PC+blood -0.657142857 -0.588235294 0 serum_phospholipids serum_phospholipids 0.262 0.00405 no no no no up up 16:0/18:1-PC+blood 20:3/16:0-PC+blood 0.807518797 0.639705882 0.403760684 serum_phospholipids serum_phospholipids 6.15E-07 0.00405 up up up no up up 16:0/18:1-PE+blood 20:3/16:0-PC+blood -0.622556391 -0.485294118 0 serum_phospholipids serum_phospholipids 0.000107 0.00405 up up no no up up 16:0/18:2-PC+blood 20:3/16:0-PC+blood 0.705263158 0.575980392 0.611623932 serum_phospholipids serum_phospholipids 3.24E-06 0.00405 no up up no up up 16:0/18:2-PI+blood 20:3/16:0-PC+blood -0.669172932 -0.708333333 0 serum_phospholipids serum_phospholipids 0.269 0.00405 no no no no up up 16:0/20:3-PC+blood 20:3/16:0-PC+blood 0.598496241 0 0.460512821 serum_phospholipids serum_phospholipids 5.43E-06 0.00405 no up up no up up 16:0/20:4-PC+blood 20:3/16:0-PC+blood 0.972932331 0.985294118 0.987692308 serum_phospholipids serum_phospholipids 0.0262 0.00405 no up no no up up 16:0/20:4-PI+blood 20:3/16:0-PC+blood -0.52481203 -0.678921569 0 serum_phospholipids serum_phospholipids 0.558 0.00405 no no no no up up 16:0/20:5-PG+blood 20:3/16:0-PC+blood 0.551879699 0 0 serum_phospholipids serum_phospholipids 0.00656 0.00405 no up no no up up 16:0/22:6-PC+blood 20:3/16:0-PC+blood 0 0.776960784 0 serum_phospholipids serum_phospholipids 4.53E-05 0.00405 no up up no up up 16:0+blood 20:3/16:0-PC+blood 0 0.482843137 0 yes serum_fattyacid serum_phospholipids 0.00876 0.00405 up no no no up up 16:1/16:0-PC+blood 20:3/16:0-PC+blood 0.633082707 0.588235294 0.520683761 serum_phospholipids serum_phospholipids 0.0215 0.00405 no up up no up up 16:1/16:1-PC+blood 20:3/16:0-PC+blood 0.646616541 0 0 serum_phospholipids serum_phospholipids 0.0177 0.00405 no no up no up up 16:1/18:1-PG+blood 20:3/16:0-PC+blood 0.49924812 0 0 serum_phospholipids serum_phospholipids 3.21E-05 0.00405 no up up no up up 16:1/18:2-PG+blood 20:3/16:0-PC+blood 0.603007519 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.00405 no up up no up up 18:0-LPA+blood 20:3/16:0-PC+blood 0 0 -0.419487179 serum_phospholipids serum_phospholipids 0.0725 0.00405 no dn no no up up 18:0-LPE+blood 20:3/16:0-PC+blood -0.497744361 0 0 serum_phospholipids serum_phospholipids 0.491 0.00405 no no no no up up 18:0/16:0-PC+blood 20:3/16:0-PC+blood 0.777443609 0.683823529 0 serum_phospholipids serum_phospholipids 9.64E-07 0.00405 up up up no up up 18:0/18:0-PE+blood 20:3/16:0-PC+blood -0.557894737 -0.681372549 0 serum_phospholipids serum_phospholipids 0.00896 0.00405 up up no no up up 18:0/18:1-PE+blood 20:3/16:0-PC+blood -0.584962406 -0.713235294 0 serum_phospholipids serum_phospholipids 0.00716 0.00405 up up no no up up 18:0/18:2-PC+blood 20:3/16:0-PC+blood 0.590977444 0 0.608888889 serum_phospholipids serum_phospholipids 1.74E-06 0.00405 no up up no up up 18:0/20:4-PC+blood 20:3/16:0-PC+blood 0.879699248 0.843137255 0.900854701 serum_phospholipids serum_phospholipids 0.454 0.00405 no no no no up up 18:0/20:5-PC+blood 20:3/16:0-PC+blood 0 0.691176471 0.667008547 serum_phospholipids serum_phospholipids 0.17 0.00405 no no no no up up 18:0/22:6-PE+blood 20:3/16:0-PC+blood -0.541353383 0 0 serum_phospholipids serum_phospholipids 0.00022 0.00405 up up no no up up 18:0/22:6-PI+blood 20:3/16:0-PC+blood -0.536842105 0 0 serum_phospholipids serum_phospholipids 0.425 0.00405 no no no no up up 18:1/16:0-PC+blood 20:3/16:0-PC+blood 0.730827068 0.580882353 0.610940171 serum_phospholipids serum_phospholipids 2.43E-05 0.00405 no up up no up up 18:1/16:0-PE+blood 20:3/16:0-PC+blood -0.484210526 -0.531862745 0 serum_phospholipids serum_phospholipids 0.000182 0.00405 up up no no up up 18:1/16:0-PI+blood 20:3/16:0-PC+blood 0 -0.740196078 0 serum_phospholipids serum_phospholipids 0.793 0.00405 no no no no up up 18:1/16:1-PE+blood 20:3/16:0-PC+blood -0.646616541 -0.514705882 0 serum_phospholipids serum_phospholipids 0.000184 0.00405 up up no no up up 18:1/18:0-PC+blood 20:3/16:0-PC+blood 0.592481203 0 0.603418803 serum_phospholipids serum_phospholipids 1.83E-06 0.00405 no up up no up up 18:1/18:0-PE+blood 20:3/16:0-PC+blood -0.562406015 -0.615196078 0 serum_phospholipids serum_phospholipids 1.39E-06 0.00405 up up no no up up 18:1/18:1-PC+blood 20:3/16:0-PC+blood 0.581954887 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.00405 no up up no up up 18:1/18:1-PE+blood 20:3/16:0-PC+blood -0.541353383 -0.531862745 0 serum_phospholipids serum_phospholipids 1.03E-05 0.00405 up up no no up up 18:1/18:1-PI+blood 20:3/16:0-PC+blood 0 -0.541666667 0 serum_phospholipids serum_phospholipids 0.111 0.00405 dn no no no up up 18:1/18:2-PE+blood 20:3/16:0-PC+blood -0.554887218 -0.732843137 0 serum_phospholipids serum_phospholipids 0.000293 0.00405 up up no no up up 18:1/18:2-PG+blood 20:3/16:0-PC+blood 0.556390977 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.00405 no up up no up up 18:1/20:3-PC+blood 20:3/16:0-PC+blood 0 0 0.495384615 serum_phospholipids serum_phospholipids 0.00872 0.00405 no up up no up up 18:1/20:4-PC+blood 20:3/16:0-PC+blood 0.655639098 0.602941176 0.764786325 serum_phospholipids serum_phospholipids 0.582 0.00405 no no no no up up 18:1/20:4-PI+blood 20:3/16:0-PC+blood 0 0 0.567179487 serum_phospholipids serum_phospholipids 0.192 0.00405 no no no no up up 18:2-LPA+blood 20:3/16:0-PC+blood 0.545864662 0 0 serum_phospholipids serum_phospholipids 0.00684 0.00405 dn no up no up up 18:2/16:0-PC+blood 20:3/16:0-PC+blood 0.601503759 0.605392157 0.59042735 serum_phospholipids serum_phospholipids 8.67E-05 0.00405 no up up no up up 18:2/20:4-PC+blood 20:3/16:0-PC+blood 0 0.482843137 0.427008547 serum_phospholipids serum_phospholipids 0.0145 0.00405 no no up no up up 18:3/16:0-PE+blood 20:3/16:0-PC+blood -0.670676692 -0.700980392 0 serum_phospholipids serum_phospholipids 0.00149 0.00405 up up no no up up 20:0-LPE+blood 20:3/16:0-PC+blood -0.490225564 -0.539215686 0 serum_phospholipids serum_phospholipids 0.0615 0.00405 no no up no up up 20:0/20:4-PE+blood 20:3/16:0-PC+blood 0 -0.512254902 0 serum_phospholipids serum_phospholipids 0.00128 0.00405 up up no no up up 20:0/20:5-PC+blood 20:3/16:0-PC+blood 0.446616541 0 0.638290598 serum_phospholipids serum_phospholipids 0.882 0.00405 no no no no up up 20:1-LPE+blood 20:3/16:0-PC+blood 0 0.507352941 0 serum_phospholipids serum_phospholipids 0.465 0.00405 no no no no up up 20:1/20:4-PC+blood 20:3/16:0-PC+blood 0 0 0.415384615 serum_phospholipids serum_phospholipids 0.0419 0.00405 no no up no up up 20:2/18:1-PE+blood 20:3/16:0-PC+blood -0.601503759 -0.647058824 0 serum_phospholipids serum_phospholipids 0.00208 0.00405 up up no no up up 20:2/18:3-PE+blood 20:3/16:0-PC+blood 0 0 0.402393162 serum_phospholipids serum_phospholipids 0.0391 0.00405 up up no no up up Alistipes 20:3/16:0-PC+blood 0.51924898 0 0 Genus serum_phospholipids 0.0114 0.00405 no up no no up up Amyotrophic lateral sclerosis 20:3/16:0-PC+blood 0 0 -0.447692308 kegg serum_phospholipids NA 0.00405 no no no no up up Asthma 20:3/16:0-PC+blood 0 0 -0.472307692 kegg serum_phospholipids NA 0.00405 no no no no up up Autophagy - animal 20:3/16:0-PC+blood 0 0 0.476153846 kegg serum_phospholipids NA 0.00405 no no no no up up Axon guidance 20:3/16:0-PC+blood 0 -0.526470588 0 kegg serum_phospholipids NA 0.00405 no up up no up up Cardiac muscle contraction 20:3/16:0-PC+blood 0 0 -0.468461538 kegg serum_phospholipids NA 0.00405 no no up no up up Cytokine-cytokine receptor interaction 20:3/16:0-PC+blood 0 0 -0.406153846 kegg serum_phospholipids NA 0.00405 no no no no up up Diabetic cardiomyopathy 20:3/16:0-PC+blood 0 0 -0.496923077 kegg serum_phospholipids NA 0.00405 no no no no up up Dilated cardiomyopathy 20:3/16:0-PC+blood 0 0 -0.487692308 kegg serum_phospholipids NA 0.00405 no up up no up up Gastric acid secretion 20:3/16:0-PC+blood 0 0 -0.493846154 kegg serum_phospholipids NA 0.00405 no no no no up up HDCA+stool 20:3/16:0-PC+blood 0.675824176 0 0 stool_bileacids serum_phospholipids 0.176 0.00405 no no no no up up Hematopoietic cell lineage 20:3/16:0-PC+blood 0 0 -0.475384615 kegg serum_phospholipids NA 0.00405 no no no no up up Hepatocellular carcinoma 20:3/16:0-PC+blood 0 0 -0.428461538 kegg serum_phospholipids NA 0.00405 no no no no up up Hippo signaling pathway 20:3/16:0-PC+blood 0 0 -0.403076923 kegg serum_phospholipids NA 0.00405 no no no no up up Huntington disease 20:3/16:0-PC+blood 0 0 -0.422307692 kegg serum_phospholipids NA 0.00405 no no no no up up Inflammatory bowel disease 20:3/16:0-PC+blood 0 0 -0.494615385 kegg serum_phospholipids NA 0.00405 no no no no up up Intestinal immune network for IgA production 20:3/16:0-PC+blood 0 0 -0.401538462 kegg serum_phospholipids NA 0.00405 no no no no up up Lachnospira 20:3/16:0-PC+blood 0 0 0.528767898 butyrate-producing Genus serum_phospholipids 0.279 0.00405 no no no no up up MAPK signaling pathway 20:3/16:0-PC+blood 0 0 0.401538462 kegg serum_phospholipids NA 0.00405 no no no no up up Non-alcoholic fatty liver disease 20:3/16:0-PC+blood 0 0 -0.459230769 kegg serum_phospholipids NA 0.00405 no no no no up up Oxidative phosphorylation 20:3/16:0-PC+blood 0 0 -0.456923077 kegg serum_phospholipids NA 0.00405 no no no no up up Prion disease 20:3/16:0-PC+blood 0 0 -0.480769231 kegg serum_phospholipids NA 0.00405 no no no no up up Renal cell carcinoma 20:3/16:0-PC+blood 0 -0.529411765 0 kegg serum_phospholipids NA 0.00405 no no no no up up Th1 and Th2 cell differentiation 20:3/16:0-PC+blood 0.547368421 0 0 kegg serum_phospholipids NA 0.00405 no no no no up up Th17 cell differentiation 20:3/16:0-PC+blood 0.494736842 0 0 kegg serum_phospholipids NA 0.00405 no no no no up up Thermogenesis 20:3/16:0-PC+blood 0 0 -0.470769231 kegg serum_phospholipids NA 0.00405 no no no no up up Thyroid hormone signaling pathway 20:3/16:0-PC+blood 0 0 -0.528461538 kegg serum_phospholipids NA 0.00405 no no no no up up Vasopressin-regulated water reabsorption 20:3/16:0-PC+blood 0 0 -0.425384615 kegg serum_phospholipids NA 0.00405 no no no no up up Vibrio cholerae infection 20:3/16:0-PC+blood 0 0 -0.415384615 kegg serum_phospholipids NA 0.00405 no no no no up up "12,13-EPOME+blood" 20:3/18:0-PC+blood 0 0 -0.403895711 serum_ARA serum_phospholipids 0.901 0.296 no no no no no no 14:0-LPC+blood 20:3/18:0-PC+blood 0 -0.693627451 -0.504957265 serum_phospholipids serum_phospholipids 0.00689 0.296 up up no no no no 14:0/20:4-PC+blood 20:3/18:0-PC+blood 0.506766917 0 0 serum_phospholipids serum_phospholipids 0.486 0.296 no no no no no no 14:0+blood 20:3/18:0-PC+blood 0 -0.558823529 0 yes serum_fattyacid serum_phospholipids 0.00572 0.296 up no dn no no no 14:1/18:2-PG+blood 20:3/18:0-PC+blood 0 -0.541666667 -0.483076923 serum_phospholipids serum_phospholipids 0.00259 0.296 no up up no no no 16:0/14:0-PC+blood 20:3/18:0-PC+blood 0 0 0.64991453 serum_phospholipids serum_phospholipids 0.0206 0.296 no up up no no no 16:0/16:0-PC+blood 20:3/18:0-PC+blood 0.684210526 0 0.540512821 serum_phospholipids serum_phospholipids 0.00079 0.296 no up up no no no 16:0/16:0-PI+blood 20:3/18:0-PC+blood 0 -0.495098039 0 serum_phospholipids serum_phospholipids 0.358 0.296 no no no no no no 16:0/18:0-PC+blood 20:3/18:0-PC+blood 0.62556391 0.487745098 0.460512821 serum_phospholipids serum_phospholipids 0.521 0.296 no no no no no no 16:0/18:1-PC+blood 20:3/18:0-PC+blood 0 0.507352941 0 serum_phospholipids serum_phospholipids 6.15E-07 0.296 up up up no no no 16:0/18:2-PC+blood 20:3/18:0-PC+blood 0 0 0.447521368 serum_phospholipids serum_phospholipids 3.24E-06 0.296 no up up no no no 16:0/18:3-PC+blood 20:3/18:0-PC+blood 0.547368421 0 0 serum_phospholipids serum_phospholipids 0.00216 0.296 no up up no no no 16:0/20:4-PC+blood 20:3/18:0-PC+blood 0 0.590686275 0 serum_phospholipids serum_phospholipids 0.0262 0.296 no up no no no no 16:0/22:0-PE+blood 20:3/18:0-PC+blood 0 0 0.502905983 serum_phospholipids serum_phospholipids 0.00839 0.296 dn no up no no no 16:0/22:6-PC+blood 20:3/18:0-PC+blood 0.610526316 0.725490196 0.596581197 serum_phospholipids serum_phospholipids 4.53E-05 0.296 no up up no no no 16:1/16:0-PC+blood 20:3/18:0-PC+blood 0.613533835 0.713235294 0.667692308 serum_phospholipids serum_phospholipids 0.0215 0.296 no up up no no no 16:1/16:1-PC+blood 20:3/18:0-PC+blood 0.72481203 0.745098039 0.645128205 serum_phospholipids serum_phospholipids 0.0177 0.296 no no up no no no 18:0-LPA+blood 20:3/18:0-PC+blood 0 0 -0.533675214 serum_phospholipids serum_phospholipids 0.0725 0.296 no dn no no no no 18:0/16:0-PC+blood 20:3/18:0-PC+blood 0 0.517156863 0 serum_phospholipids serum_phospholipids 9.64E-07 0.296 up up up no no no 18:0/18:0-PC+blood 20:3/18:0-PC+blood 0 0 0.40991453 serum_phospholipids serum_phospholipids 0.426 0.296 no no no no no no 18:0/18:0-PE+blood 20:3/18:0-PC+blood 0 0 -0.548717949 serum_phospholipids serum_phospholipids 0.00896 0.296 up up no no no no 18:0/18:0-PS+blood 20:3/18:0-PC+blood 0.615037594 0 -0.404444444 serum_phospholipids serum_phospholipids 0.00617 0.296 no up no no no no 18:0/18:1-PE+blood 20:3/18:0-PC+blood 0 -0.492647059 -0.58017094 serum_phospholipids serum_phospholipids 0.00716 0.296 up up no no no no 18:0/18:1-PG+blood 20:3/18:0-PC+blood 0 -0.50245098 -0.524102564 serum_phospholipids serum_phospholipids 0.000842 0.296 no up no no no no 18:0/18:2-PC+blood 20:3/18:0-PC+blood 0.445112782 0 0.628717949 serum_phospholipids serum_phospholipids 1.74E-06 0.296 no up up no no no 18:0/20:4-PC+blood 20:3/18:0-PC+blood 0 0.683823529 0 serum_phospholipids serum_phospholipids 0.454 0.296 no no no no no no 18:0/20:5-PC+blood 20:3/18:0-PC+blood 0 0 0.45025641 serum_phospholipids serum_phospholipids 0.17 0.296 no no no no no no 18:0/22:6-PA+blood 20:3/18:0-PC+blood 0.676691729 0.634803922 0 serum_phospholipids serum_phospholipids 0.22 0.296 no no no no no no 18:0/22:6-PC+blood 20:3/18:0-PC+blood 0 0.526960784 0.440683761 serum_phospholipids serum_phospholipids 0.0775 0.296 no no up no no no 18:1-LPE+blood 20:3/18:0-PC+blood -0.630075188 0 0 serum_phospholipids serum_phospholipids 0.117 0.296 no no no no no no 18:1/16:0-PC+blood 20:3/18:0-PC+blood 0 0 0.447521368 serum_phospholipids serum_phospholipids 2.43E-05 0.296 no up up no no no 18:1/16:0-PE+blood 20:3/18:0-PC+blood 0 0 -0.501538462 serum_phospholipids serum_phospholipids 0.000182 0.296 up up no no no no 18:1/18:0-PC+blood 20:3/18:0-PC+blood 0 0 0.643760684 serum_phospholipids serum_phospholipids 1.83E-06 0.296 no up up no no no 18:1/18:0-PE+blood 20:3/18:0-PC+blood 0 -0.514705882 -0.500854701 serum_phospholipids serum_phospholipids 1.39E-06 0.296 up up no no no no 18:1/18:0-PS+blood 20:3/18:0-PC+blood 0.551879699 0 0 serum_phospholipids serum_phospholipids 0.193 0.296 no no no no no no 18:1/18:1-PE+blood 20:3/18:0-PC+blood 0 0 -0.472820513 serum_phospholipids serum_phospholipids 1.03E-05 0.296 up up no no no no 18:1/18:2-PE+blood 20:3/18:0-PC+blood 0 0 -0.48034188 serum_phospholipids serum_phospholipids 0.000293 0.296 up up no no no no 18:1/20:4-PC+blood 20:3/18:0-PC+blood 0 0.593137255 0 serum_phospholipids serum_phospholipids 0.582 0.296 no no no no no no 18:2/16:0-PC+blood 20:3/18:0-PC+blood 0 0 0.492649573 serum_phospholipids serum_phospholipids 8.67E-05 0.296 no up up no no no 18:3n3+blood 20:3/18:0-PC+blood 0.479699248 0 0 serum_fattyacid serum_phospholipids 0.291 0.296 no no no no no no 20:0/20:4-PE+blood 20:3/18:0-PC+blood 0 -0.553921569 -0.405128205 serum_phospholipids serum_phospholipids 0.00128 0.296 up up no no no no 20:0/20:5-PC+blood 20:3/18:0-PC+blood 0.50075188 0.524509804 0 serum_phospholipids serum_phospholipids 0.882 0.296 no no no no no no 20:0+blood 20:3/18:0-PC+blood -0.476691729 0 0 yes serum_fattyacid serum_phospholipids 0.000278 0.296 dn no up no no no 20:1-LPC+blood 20:3/18:0-PC+blood 0 0 0.417435897 serum_phospholipids serum_phospholipids 0.217 0.296 no no no no no no 20:1-LPE+blood 20:3/18:0-PC+blood 0 0.487745098 0 serum_phospholipids serum_phospholipids 0.465 0.296 no no no no no no 20:1/20:4-PC+blood 20:3/18:0-PC+blood 0.446616541 0.625 0.521367521 serum_phospholipids serum_phospholipids 0.0419 0.296 no no up no no no 20:2-LPC+blood 20:3/18:0-PC+blood 0 0.526960784 0.457094017 serum_phospholipids serum_phospholipids 0.119 0.296 no no up no no no 20:2/18:1-PE+blood 20:3/18:0-PC+blood 0 0 -0.405128205 serum_phospholipids serum_phospholipids 0.00208 0.296 up up no no no no 20:3/16:0-PC+blood 20:3/18:0-PC+blood 0 0.585784314 0 serum_phospholipids serum_phospholipids 0.00405 0.296 no up up no no no Amphetamine addiction 20:3/18:0-PC+blood -0.561403509 0 0 kegg serum_phospholipids NA 0.296 no no no no no no Axon guidance 20:3/18:0-PC+blood 0 -0.5 0 kegg serum_phospholipids NA 0.296 no up up no no no Bacteroides 20:3/18:0-PC+blood 0 0.573529412 0 LPS-producing Genus serum_phospholipids 0.000267 0.296 dn dn up no no no Biosynthesis of amino acids 20:3/18:0-PC+blood 0.547368421 0 0 kegg serum_phospholipids NA 0.296 no no no no no no cAMP signaling pathway 20:3/18:0-PC+blood -0.464912281 0 0 yes kegg serum_phospholipids NA 0.296 no up up no no no Carbon metabolism 20:3/18:0-PC+blood 0.512280702 0 0.458461538 kegg serum_phospholipids NA 0.296 no no no no no no Choline metabolism in cancer 20:3/18:0-PC+blood 0 0 -0.418461538 kegg serum_phospholipids NA 0.296 no no no no no no Cushing syndrome 20:3/18:0-PC+blood -0.496491228 0 0 kegg serum_phospholipids NA 0.296 no no up no no no DCA+stool 20:3/18:0-PC+blood 0 0 -0.664661654 stool_bileacids serum_phospholipids 0.195 0.296 no no no no no no Dopaminergic synapse 20:3/18:0-PC+blood -0.614035088 0 0 kegg serum_phospholipids NA 0.296 no up no no no no GCDCA+stool 20:3/18:0-PC+blood 0 0 0.452631579 yes stool_bileacids serum_phospholipids 0.0471 0.296 no dn no no no no GDCA+stool 20:3/18:0-PC+blood 0 0 0.525603006 stool_bileacids serum_phospholipids 0.656 0.296 no no no no no no Glioma 20:3/18:0-PC+blood 0 -0.594117647 0 kegg serum_phospholipids NA 0.296 no no no no no no Glycolysis / Gluconeogenesis 20:3/18:0-PC+blood 0 0 0.429230769 kegg serum_phospholipids NA 0.296 no no no no no no HCA+stool 20:3/18:0-PC+blood 0.593406593 0 0 stool_bileacids serum_phospholipids 0.155 0.296 no no no no no no L-Phenylalanine+stool 20:3/18:0-PC+blood 0 0 0.45112782 stool_cometabolism serum_phospholipids 0.398 0.296 no no no no no no L-Tryptophan+stool 20:3/18:0-PC+blood 0 0 0.445112782 stool_cometabolism serum_phospholipids 0.557 0.296 no no no no no no LCA+stool 20:3/18:0-PC+blood 0 0 -0.488721805 stool_bileacids serum_phospholipids 0.314 0.296 no no no no no no Lysosome 20:3/18:0-PC+blood 0.457894737 0 0 kegg serum_phospholipids NA 0.296 no no no no no no Mineral absorption 20:3/18:0-PC+blood -0.547368421 0 0 kegg serum_phospholipids NA 0.296 no no no no no no Mitophagy - animal 20:3/18:0-PC+blood -0.554385965 0 0 kegg serum_phospholipids NA 0.296 no no no no no no Necroptosis 20:3/18:0-PC+blood -0.580701754 0 0 kegg serum_phospholipids NA 0.296 no no no no no no NOD-like receptor signaling pathway 20:3/18:0-PC+blood 0.487719298 0 0 kegg serum_phospholipids NA 0.296 no no no no no no nutriCA+stool 20:3/18:0-PC+blood 0.56043956 0 0 stool_bileacids serum_phospholipids 0.481 0.296 no no no no no no Pancreatic cancer 20:3/18:0-PC+blood 0 0 -0.526153846 kegg serum_phospholipids NA 0.296 no no no no no no Pancreatic secretion 20:3/18:0-PC+blood -0.484210526 0 0 kegg serum_phospholipids NA 0.296 no no no no no no "Parathyroid hormone synthesis, secretion and action" 20:3/18:0-PC+blood -0.510526316 0 0 kegg serum_phospholipids NA 0.296 no no no no no no Parkinson disease 20:3/18:0-PC+blood -0.585964912 0 0 kegg serum_phospholipids NA 0.296 no no no no no no Pathways of neurodegeneration - multiple diseases 20:3/18:0-PC+blood -0.592982456 0 0 kegg serum_phospholipids NA 0.296 no no no no no no Peroxisome 20:3/18:0-PC+blood 0.501754386 0 0 kegg serum_phospholipids NA 0.296 no no no no no no Pertussis 20:3/18:0-PC+blood 0.471929825 0 0 kegg serum_phospholipids NA 0.296 no no dn no no no Prevotella 20:3/18:0-PC+blood -0.568589366 -0.535871396 0 acetate-producing Genus serum_phospholipids 0.287 0.296 no no no no no no Propionic acid+stool 20:3/18:0-PC+blood 0 0 -0.687218045 yes stool_scfa serum_phospholipids 0.0436 0.296 dn no up no no no Relaxin signaling pathway 20:3/18:0-PC+blood -0.468421053 0 0 kegg serum_phospholipids NA 0.296 no no no no no no Shigellosis 20:3/18:0-PC+blood -0.561403509 0 0 kegg serum_phospholipids NA 0.296 no no no no no no Systemic lupus erythematosus 20:3/18:0-PC+blood 0.552631579 0 0 kegg serum_phospholipids NA 0.296 no no no no no no Thermogenesis 20:3/18:0-PC+blood -0.505263158 0 0 kegg serum_phospholipids NA 0.296 no no no no no no total_stool_scfa+stool 20:3/18:0-PC+blood 0 0 -0.517293233 stool_scfa serum_phospholipids 0.0534 0.296 dn no up no no no Transcriptional misregulation in cancer 20:3/18:0-PC+blood 0 0 -0.475384615 kegg serum_phospholipids NA 0.296 no no no no no no Tuberculosis 20:3/18:0-PC+blood 0.526315789 0 0 kegg serum_phospholipids NA 0.296 no no dn no no no Ubiquitin mediated proteolysis 20:3/18:0-PC+blood -0.585964912 0 0 kegg serum_phospholipids NA 0.296 no no no no no no 16:0/18:0-PC+blood 20:3/18:0-PI+blood 0 0.524509804 0 serum_phospholipids serum_phospholipids 0.521 0.289 no no no no no no 16:0/18:0-PS+blood 20:3/18:0-PI+blood 0 0.629901961 0.483076923 serum_phospholipids serum_phospholipids 0.377 0.289 no no no no no no 16:0/20:5-PG+blood 20:3/18:0-PI+blood 0.621052632 0 0.484444444 serum_phospholipids serum_phospholipids 0.00656 0.289 no up no no no no 16:1/16:1-PC+blood 20:3/18:0-PI+blood 0.55037594 0 0 serum_phospholipids serum_phospholipids 0.0177 0.289 no no up no no no 16:1/18:1-PG+blood 20:3/18:0-PI+blood 0.508270677 0 0.444102564 serum_phospholipids serum_phospholipids 3.21E-05 0.289 no up up no no no 16:1/18:2-PG+blood 20:3/18:0-PI+blood 0 0 0.455726496 serum_phospholipids serum_phospholipids 1.40E-08 0.289 no up up no no no 18:0/18:0-PS+blood 20:3/18:0-PI+blood 0 0.490196078 0.545299145 serum_phospholipids serum_phospholipids 0.00617 0.289 no up no no no no 18:0/18:1-PG+blood 20:3/18:0-PI+blood 0 0 0.600683761 serum_phospholipids serum_phospholipids 0.000842 0.289 no up no no no no 18:0/18:1-PI+blood 20:3/18:0-PI+blood 0.446616541 0 0 serum_phospholipids serum_phospholipids 0.599 0.289 no no no no no no 18:0/18:2-PI+blood 20:3/18:0-PI+blood 0 0.566176471 0.505641026 serum_phospholipids serum_phospholipids 0.179 0.289 no no no no no no 18:0/20:3-PI+blood 20:3/18:0-PI+blood 0.655639098 0 0.502905983 serum_phospholipids serum_phospholipids 0.377 0.289 no no no no no no 18:0/20:4-PC+blood 20:3/18:0-PI+blood 0.526315789 0 0 serum_phospholipids serum_phospholipids 0.454 0.289 no no no no no no 18:0/20:4-PI+blood 20:3/18:0-PI+blood 0.977443609 0.975490196 0.987008547 serum_phospholipids serum_phospholipids 0.167 0.289 no no no no no no 18:0/22:6-PA+blood 20:3/18:0-PI+blood 0 0.610294118 0 serum_phospholipids serum_phospholipids 0.22 0.289 no no no no no no 18:1-LPC+blood 20:3/18:0-PI+blood 0.511278195 0 0 serum_phospholipids serum_phospholipids 0.179 0.289 no no no no no no 18:1-LPE+blood 20:3/18:0-PI+blood 0 0 -0.477606838 serum_phospholipids serum_phospholipids 0.117 0.289 no no no no no no 18:1/18:0-PI+blood 20:3/18:0-PI+blood 0.454135338 0 0 serum_phospholipids serum_phospholipids 0.0931 0.289 no no up no no no 18:1/18:0-PS+blood 20:3/18:0-PI+blood 0 0.68627451 0.491965812 serum_phospholipids serum_phospholipids 0.193 0.289 no no no no no no 18:1/18:1-PI+blood 20:3/18:0-PI+blood 0.496240602 0 0 serum_phospholipids serum_phospholipids 0.111 0.289 dn no no no no no 18:1/20:4-PC+blood 20:3/18:0-PI+blood 0.535338346 0 0 serum_phospholipids serum_phospholipids 0.582 0.289 no no no no no no 18:1+blood 20:3/18:0-PI+blood 0.496240602 0 0 yes serum_fattyacid serum_phospholipids 0.00202 0.289 up no dn no no no 18:2-LPC+blood 20:3/18:0-PI+blood 0 0 -0.498119658 serum_phospholipids serum_phospholipids 0.00743 0.289 dn no up no no no 18:2/18:2-PC+blood 20:3/18:0-PI+blood 0 0 -0.411282051 serum_phospholipids serum_phospholipids 1.98E-05 0.289 dn up up no no no 18:2/18:2-PS+blood 20:3/18:0-PI+blood 0 0 0.443418803 serum_phospholipids serum_phospholipids 0.00674 0.289 up up no no no no 18:3-LPC+blood 20:3/18:0-PI+blood -0.747368421 0 -0.409230769 serum_phospholipids serum_phospholipids 0.147 0.289 no no no no no no 20:0/20:5-PC+blood 20:3/18:0-PI+blood 0.729323308 0 0 serum_phospholipids serum_phospholipids 0.882 0.289 no no no no no no 20:1/20:4-PE+blood 20:3/18:0-PI+blood 0.551879699 0 0.447521368 serum_phospholipids serum_phospholipids 0.0042 0.289 up up no no no no 20:2-LPC+blood 20:3/18:0-PI+blood 0.448120301 0 0 serum_phospholipids serum_phospholipids 0.119 0.289 no no up no no no 20:2/18:3-PE+blood 20:3/18:0-PI+blood 0 0.639705882 0 serum_phospholipids serum_phospholipids 0.0391 0.289 up up no no no no 11-HETE+blood 20:3n6+blood 0 0.673953059 0 serum_ARA serum_fattyacid 0.464 0.0884 no no no up no no 14:0-LPC+blood 20:3n6+blood 0.601503759 0 0.582905983 serum_phospholipids serum_fattyacid 0.00689 0.0884 up up no up no no 14:0/16:0-PC+blood 20:3n6+blood 0 0.595588235 0.563760684 serum_phospholipids serum_fattyacid 0.0358 0.0884 no up no up no no 14:0/18:0-PC+blood 20:3n6+blood 0 0.825980392 0.599316239 serum_phospholipids serum_fattyacid 0.00289 0.0884 up up no up no no 14:0/18:2-PC+blood 20:3n6+blood 0 0 0.433846154 serum_phospholipids serum_fattyacid 0.102 0.0884 no up no up no no 14:0+blood 20:3n6+blood 0.542857143 0 0.496752137 yes serum_fattyacid serum_fattyacid 0.00572 0.0884 up no dn up no no 14:1/18:2-PG+blood 20:3n6+blood 0 0 0.485128205 serum_phospholipids serum_fattyacid 0.00259 0.0884 no up up up no no 16:0-LPE+blood 20:3n6+blood 0 0 0.446153846 serum_phospholipids serum_fattyacid 0.0711 0.0884 up up no up no no 16:0/16:0-PC+blood 20:3n6+blood -0.488721805 0 0 serum_phospholipids serum_fattyacid 0.00079 0.0884 no up up up no no 16:0/16:0-PI+blood 20:3n6+blood 0 0.522058824 0.44957265 serum_phospholipids serum_fattyacid 0.358 0.0884 no no no up no no 16:0/16:1-PC+blood 20:3n6+blood 0 0.835784314 0.617777778 serum_phospholipids serum_fattyacid 0.00283 0.0884 up up no up no no 16:0/16:1-PI+blood 20:3n6+blood 0.491729323 0.781862745 0.595897436 serum_phospholipids serum_fattyacid 0.262 0.0884 no no no up no no 16:0/18:1-PC+blood 20:3n6+blood -0.476691729 0 0 serum_phospholipids serum_fattyacid 6.15E-07 0.0884 up up up up no no 16:0/18:1-PE+blood 20:3n6+blood 0 0.639705882 0 serum_phospholipids serum_fattyacid 0.000107 0.0884 up up no up no no 16:0/18:2-PI+blood 20:3n6+blood 0.521804511 0.534313725 0.494017094 serum_phospholipids serum_fattyacid 0.269 0.0884 no no no up no no 16:0/18:3-PC+blood 20:3n6+blood 0 0 0.418119658 serum_phospholipids serum_fattyacid 0.00216 0.0884 no up up up no no 16:0/20:3-PC+blood 20:3n6+blood 0 0.683823529 0.580854701 serum_phospholipids serum_fattyacid 5.43E-06 0.0884 no up up up no no 16:0/20:4-PI+blood 20:3n6+blood 0.490225564 0 0.537777778 serum_phospholipids serum_fattyacid 0.558 0.0884 no no no up no no 16:0/22:6-PC+blood 20:3n6+blood 0 -0.534313725 0 serum_phospholipids serum_fattyacid 4.53E-05 0.0884 no up up up no no 16:0+blood 20:3n6+blood 0 0 0.624615385 yes serum_fattyacid serum_fattyacid 0.00876 0.0884 up no no up no no 16:1-LPC+blood 20:3n6+blood 0 0 0.53025641 serum_phospholipids serum_fattyacid 0.0241 0.0884 no up no up no no 16:1/18:1-PG+blood 20:3n6+blood 0 0.642156863 0 serum_phospholipids serum_fattyacid 3.21E-05 0.0884 no up up up no no 18:0/16:0-PC+blood 20:3n6+blood -0.526315789 0 0 serum_phospholipids serum_fattyacid 9.64E-07 0.0884 up up up up no no 18:0/18:0-PC+blood 20:3n6+blood 0 0.571078431 0 serum_phospholipids serum_fattyacid 0.426 0.0884 no no no up no no 18:0/18:1-PC+blood 20:3n6+blood 0 0.566176471 0 serum_phospholipids serum_fattyacid 0.393 0.0884 no no no up no no 18:0/18:1-PI+blood 20:3n6+blood 0 0.659313725 0 serum_phospholipids serum_fattyacid 0.599 0.0884 no no no up no no 18:0/20:2-PC+blood 20:3n6+blood 0 0.588235294 0 serum_phospholipids serum_fattyacid 0.733 0.0884 no no no up no no 18:0/20:3-PC+blood 20:3n6+blood 0.54887218 0.828431373 0.802393162 serum_phospholipids serum_fattyacid 0.0682 0.0884 no up no up no no 18:0/20:3-PI+blood 20:3n6+blood 0 0.830882353 0.521367521 serum_phospholipids serum_fattyacid 0.377 0.0884 no no no up no no 18:0/20:4-PC+blood 20:3n6+blood 0 -0.553921569 0 serum_phospholipids serum_fattyacid 0.454 0.0884 no no no up no no 18:0/20:5-PC+blood 20:3n6+blood 0 -0.68627451 -0.409230769 serum_phospholipids serum_fattyacid 0.17 0.0884 no no no up no no 18:0+blood 20:3n6+blood 0.493233083 0 0 serum_fattyacid serum_fattyacid 0.344 0.0884 no no no up no no 18:1/16:0-PI+blood 20:3n6+blood 0 0.588235294 0 serum_phospholipids serum_fattyacid 0.793 0.0884 no no no up no no 18:1/16:1-PE+blood 20:3n6+blood 0 0.656862745 0 serum_phospholipids serum_fattyacid 0.000184 0.0884 up up no up no no 18:1/18:0-PE+blood 20:3n6+blood 0 0.514705882 0 serum_phospholipids serum_fattyacid 1.39E-06 0.0884 up up no up no no 18:1/18:1-PC+blood 20:3n6+blood 0 0.781862745 0.598632479 serum_phospholipids serum_fattyacid 1.34E-05 0.0884 no up up up no no 18:1/18:1-PE+blood 20:3n6+blood 0 0.512254902 0 serum_phospholipids serum_fattyacid 1.03E-05 0.0884 up up no up no no 18:1/18:1-PG+blood 20:3n6+blood 0 0.772058824 0 serum_phospholipids serum_fattyacid 0.00352 0.0884 no up up up no no 18:1/18:2-PG+blood 20:3n6+blood 0 0.620098039 0 serum_phospholipids serum_fattyacid 5.58E-07 0.0884 no up up up no no 18:1/20:3-PC+blood 20:3n6+blood 0 0.580882353 0.495384615 serum_phospholipids serum_fattyacid 0.00872 0.0884 no up up up no no 18:1/20:4-PC+blood 20:3n6+blood 0 -0.512254902 0 serum_phospholipids serum_fattyacid 0.582 0.0884 no no no up no no 18:2-LPC+blood 20:3n6+blood 0 0 -0.455042735 serum_phospholipids serum_fattyacid 0.00743 0.0884 dn no up up no no 18:2/18:2-PS+blood 20:3n6+blood 0 0.781862745 0 serum_phospholipids serum_fattyacid 0.00674 0.0884 up up no up no no 18:3-LPC+blood 20:3n6+blood 0 -0.700980392 0 serum_phospholipids serum_fattyacid 0.147 0.0884 no no no up no no 18:3/18:2-PC+blood 20:3n6+blood 0 0 -0.43042735 serum_phospholipids serum_fattyacid 0.0394 0.0884 no no up up no no 18:3n3+blood 20:3n6+blood 0 -0.68627451 0 serum_fattyacid serum_fattyacid 0.291 0.0884 no no no up no no 18:3n6+blood 20:3n6+blood 0.580451128 0 0 serum_fattyacid serum_fattyacid 0.0463 0.0884 up no dn up no no 20:1-LPC+blood 20:3n6+blood -0.517293233 0 0 serum_phospholipids serum_fattyacid 0.217 0.0884 no no no up no no 20:2/18:0-PC+blood 20:3n6+blood 0.541353383 0.816176471 0.816752137 serum_phospholipids serum_fattyacid 0.0427 0.0884 no up no up no no 20:2/18:1-PE+blood 20:3n6+blood 0 0.681372549 0.56034188 serum_phospholipids serum_fattyacid 0.00208 0.0884 up up no up no no 20:3-LPC+blood 20:3n6+blood 0.798496241 0.75245098 0.796239316 serum_phospholipids serum_fattyacid 0.0292 0.0884 no up no up no no 20:3-LPE+blood 20:3n6+blood 0 0.607843137 0.518632479 serum_phospholipids serum_fattyacid 0.084 0.0884 no up no up no no 3-(3-Hydroxyphenyl)propanoic acid+stool 20:3n6+blood 0.653846154 0 0 stool_cometabolism serum_fattyacid 0.33 0.0884 no no no up no no Adipocytokine signaling pathway 20:3n6+blood 0 0 0.506923077 kegg serum_fattyacid NA 0.0884 no no no up no no Arachidonic acid metabolism 20:3n6+blood 0 0 0.434615385 kegg serum_fattyacid NA 0.0884 no no no up no no Arginine and proline metabolism 20:3n6+blood 0 0 0.466153846 kegg serum_fattyacid NA 0.0884 no up no up no no Biosynthesis of cofactors 20:3n6+blood 0 0 0.444615385 kegg serum_fattyacid NA 0.0884 no no no up no no CDCA+stool 20:3n6+blood 0 0.654545455 0 stool_bileacids serum_fattyacid 0.663 0.0884 no no no up no no Central carbon metabolism in cancer 20:3n6+blood 0 0 -0.531538462 kegg serum_fattyacid NA 0.0884 no no no up no no Clostridium 20:3n6+blood 0 0.533415183 0 Genus serum_fattyacid 0.925 0.0884 no no no up no no Epstein-Barr virus infection 20:3n6+blood 0 0.582352941 0 kegg serum_fattyacid NA 0.0884 no no no up no no Ferroptosis 20:3n6+blood 0 0 0.475384615 kegg serum_fattyacid NA 0.0884 no no no up no no FoxO signaling pathway 20:3n6+blood 0 0 -0.688461538 kegg serum_fattyacid NA 0.0884 no no no up no no Gastric cancer 20:3n6+blood 0 0 -0.41 kegg serum_fattyacid NA 0.0884 no no no up no no GCDCA+stool 20:3n6+blood 0 0.690909091 0 yes stool_bileacids serum_fattyacid 0.0471 0.0884 no dn no up no no Glutathione metabolism 20:3n6+blood 0 0 0.538461538 kegg serum_fattyacid NA 0.0884 no no no up no no "Glycine, serine and threonine metabolism" 20:3n6+blood 0 0 0.461538462 kegg serum_fattyacid NA 0.0884 no up no up no no Human cytomegalovirus infection 20:3n6+blood 0 0.5 0 kegg serum_fattyacid NA 0.0884 no no dn up no no Human immunodeficiency virus 1 infection 20:3n6+blood 0 0.535294118 0 kegg serum_fattyacid NA 0.0884 no no no up no no Human T-cell leukemia virus 1 infection 20:3n6+blood 0 0.517647059 0 kegg serum_fattyacid NA 0.0884 no no no up no no Kaposi sarcoma-associated herpesvirus infection 20:3n6+blood 0 0 0.582307692 kegg serum_fattyacid NA 0.0884 no no dn up no no Longevity regulating pathway 20:3n6+blood 0 0 0.403076923 kegg serum_fattyacid NA 0.0884 no no no up no no MAPK signaling pathway 20:3n6+blood 0 -0.602941176 0 kegg serum_fattyacid NA 0.0884 no no no up no no nutriCA+stool 20:3n6+blood 0 0.706451749 0 stool_bileacids serum_fattyacid 0.481 0.0884 no no no up no no Oocyte meiosis 20:3n6+blood 0 0 -0.471538462 kegg serum_fattyacid NA 0.0884 no no no up no no Phenylacetic acid+stool 20:3n6+blood 0 -0.636363636 0 stool_cometabolism serum_fattyacid 0.785 0.0884 no no no up no no Phosphatidylinositol signaling system 20:3n6+blood 0 0 -0.419230769 kegg serum_fattyacid NA 0.0884 no no no up no no Platinum drug resistance 20:3n6+blood 0 0 -0.428461538 kegg serum_fattyacid NA 0.0884 no no no up no no Porphyrin and chlorophyll metabolism 20:3n6+blood 0 0 0.49 kegg serum_fattyacid NA 0.0884 no no no up no no Primary immunodeficiency 20:3n6+blood 0 0 -0.556153846 kegg serum_fattyacid NA 0.0884 no no no up no no Progesterone-mediated oocyte maturation 20:3n6+blood 0 0 -0.586153846 kegg serum_fattyacid NA 0.0884 no no no up no no Purine metabolism 20:3n6+blood 0 0 0.426153846 kegg serum_fattyacid NA 0.0884 no no no up no no Roseburia 20:3n6+blood 0 0.571428679 0 butyrate-producing Genus serum_fattyacid 0.495 0.0884 no no no up no no Shigellosis 20:3n6+blood 0 0 0.423076923 kegg serum_fattyacid NA 0.0884 no no no up no no Sphingolipid signaling pathway 20:3n6+blood 0 0 -0.542307692 kegg serum_fattyacid NA 0.0884 no no no up no no Spinocerebellar ataxia 20:3n6+blood 0 0 -0.428461538 kegg serum_fattyacid NA 0.0884 no no no up no no Thyroid hormone synthesis 20:3n6+blood 0 0 0.423076923 kegg serum_fattyacid NA 0.0884 no no no up no no 16:0/22:6-PE+blood 20:4-LPA+blood 0 -0.649509804 0 serum_phospholipids serum_phospholipids 0.000934 0.398 up up no no no no 16:0+blood 20:4-LPA+blood 0.502255639 0 0 yes serum_fattyacid serum_phospholipids 0.00876 0.398 up no no no no no 16:1+blood 20:4-LPA+blood 0 -0.573529412 -0.425641026 yes serum_fattyacid serum_phospholipids 0.0186 0.398 no no dn no no no 18:0-LPA+blood 20:4-LPA+blood 0.493233083 0.600490196 0 serum_phospholipids serum_phospholipids 0.0725 0.398 no dn no no no no 18:1/20:4-PC+blood 20:4-LPA+blood 0 0 0.437948718 serum_phospholipids serum_phospholipids 0.582 0.398 no no no no no no 18:1/20:4-PE+blood 20:4-LPA+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.0578 0.398 up no no no no no 18:3/16:0-PE+blood 20:4-LPA+blood 0 -0.62745098 0 serum_phospholipids serum_phospholipids 0.00149 0.398 up up no no no no 20:0-LPC+blood 20:4-LPA+blood -0.508270677 0 0 serum_phospholipids serum_phospholipids 0.199 0.398 no no no no no no 20:0+blood 20:4-LPA+blood -0.446616541 0 0 yes serum_fattyacid serum_phospholipids 0.000278 0.398 dn no up no no no 20:1-LPA+blood 20:4-LPA+blood 0 0.681372549 0.731965812 serum_phospholipids serum_phospholipids 0.0187 0.398 dn dn no no no no 20:2/18:1-PE+blood 20:4-LPA+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.00208 0.398 up up no no no no B cell receptor signaling pathway 20:4-LPA+blood 0 0.5 0 kegg serum_phospholipids NA 0.398 no no no no no no Butyricimonas 20:4-LPA+blood 0 -0.579045868 0 butyrate-producing Genus serum_phospholipids 0.17 0.398 no no no no no no Cell cycle 20:4-LPA+blood 0 -0.655882353 0 kegg serum_phospholipids NA 0.398 no no no no no no Central carbon metabolism in cancer 20:4-LPA+blood 0.61754386 0 0 kegg serum_phospholipids NA 0.398 no no no no no no cGMP-PKG signaling pathway 20:4-LPA+blood 0 0.576470588 0 kegg serum_phospholipids NA 0.398 no no no no no no Cytokine-cytokine receptor interaction 20:4-LPA+blood 0 0.570588235 0 kegg serum_phospholipids NA 0.398 no no no no no no Epithelial cell signaling in Helicobacter pylori infection 20:4-LPA+blood 0 0.561764706 0 kegg serum_phospholipids NA 0.398 no no no no no no Fc gamma R-mediated phagocytosis 20:4-LPA+blood 0 0.544117647 0 kegg serum_phospholipids NA 0.398 no no no no no no FoxO signaling pathway 20:4-LPA+blood 0.464912281 0 0 kegg serum_phospholipids NA 0.398 no no no no no no Glutathione metabolism 20:4-LPA+blood -0.464912281 0 0 kegg serum_phospholipids NA 0.398 no no no no no no IL-17 signaling pathway 20:4-LPA+blood 0 0.591176471 0 kegg serum_phospholipids NA 0.398 no no no no no no JAK-STAT signaling pathway 20:4-LPA+blood 0.531578947 0 0 kegg serum_phospholipids NA 0.398 no no no no no no Kaposi sarcoma-associated herpesvirus infection 20:4-LPA+blood -0.480701754 0 0 kegg serum_phospholipids NA 0.398 no no dn no no no Lipid and atherosclerosis 20:4-LPA+blood 0 0.626470588 0 kegg serum_phospholipids NA 0.398 no no no no no no Longevity regulating pathway - multiple species 20:4-LPA+blood 0.475438596 0 0 kegg serum_phospholipids NA 0.398 no no no no no no mRNA surveillance pathway 20:4-LPA+blood 0 -0.655882353 0 kegg serum_phospholipids NA 0.398 no no no no no no Olfactory transduction 20:4-LPA+blood 0 0.564705882 0 kegg serum_phospholipids NA 0.398 no no no no no no Oocyte meiosis 20:4-LPA+blood 0 -0.526470588 0 kegg serum_phospholipids NA 0.398 no no no no no no Pathogenic Escherichia coli infection 20:4-LPA+blood 0 0.6 0 kegg serum_phospholipids NA 0.398 no no no no no no Progesterone-mediated oocyte maturation 20:4-LPA+blood 0.49122807 0 0 kegg serum_phospholipids NA 0.398 no no no no no no Protein processing in endoplasmic reticulum 20:4-LPA+blood 0 -0.635294118 0 kegg serum_phospholipids NA 0.398 no no no no no no Ras signaling pathway 20:4-LPA+blood 0 -0.638235294 0 yes kegg serum_phospholipids NA 0.398 no up up no no no Rheumatoid arthritis 20:4-LPA+blood 0 0.532352941 0 kegg serum_phospholipids NA 0.398 no no no no no no Ribosome biogenesis in eukaryotes 20:4-LPA+blood 0 -0.544117647 0 kegg serum_phospholipids NA 0.398 no no no no no no RNA degradation 20:4-LPA+blood 0 -0.502941176 0 kegg serum_phospholipids NA 0.398 no no no no no no Shigellosis 20:4-LPA+blood -0.526315789 0 0 kegg serum_phospholipids NA 0.398 no no no no no no Spinocerebellar ataxia 20:4-LPA+blood 0 -0.608823529 0 kegg serum_phospholipids NA 0.398 no no no no no no Toll-like receptor signaling pathway 20:4-LPA+blood 0 0.505882353 0 yes kegg serum_phospholipids NA 0.398 no no no no no no Toxoplasmosis 20:4-LPA+blood 0 0.535294118 0 kegg serum_phospholipids NA 0.398 no no no no no no Wnt signaling pathway 20:4-LPA+blood 0 -0.541176471 0 kegg serum_phospholipids NA 0.398 no no no no no no 11-HETE+blood 20:4-LPC+blood 0 -0.539162447 0 serum_ARA serum_phospholipids 0.464 0.949 no no no no no no 12-ketoDCA+blood 20:4-LPC+blood 0 0 -0.476303222 serum_bileacids serum_phospholipids 0.517 0.949 no no no no no no 14:0/18:0-PC+blood 20:4-LPC+blood 0 -0.735294118 0 serum_phospholipids serum_phospholipids 0.00289 0.949 up up no no no no 16:0/16:0-PI+blood 20:4-LPC+blood 0 -0.553921569 0 serum_phospholipids serum_phospholipids 0.358 0.949 no no no no no no 16:0/16:1-PC+blood 20:4-LPC+blood 0 -0.767156863 0 serum_phospholipids serum_phospholipids 0.00283 0.949 up up no no no no 16:0/16:1-PI+blood 20:4-LPC+blood 0 -0.617647059 0 serum_phospholipids serum_phospholipids 0.262 0.949 no no no no no no 16:0/18:1-PE+blood 20:4-LPC+blood 0 -0.720588235 0 serum_phospholipids serum_phospholipids 0.000107 0.949 up up no no no no 16:0/18:2-PI+blood 20:4-LPC+blood 0 -0.68627451 0 serum_phospholipids serum_phospholipids 0.269 0.949 no no no no no no 16:0/20:3-PC+blood 20:4-LPC+blood 0 -0.490196078 0 serum_phospholipids serum_phospholipids 5.43E-06 0.949 no up up no no no 16:0/20:4-PC+blood 20:4-LPC+blood 0.630075188 0.605392157 0.435897436 serum_phospholipids serum_phospholipids 0.0262 0.949 no up no no no no 16:0/20:4-PE+blood 20:4-LPC+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.00139 0.949 up up no no no no 16:0/20:5-PG+blood 20:4-LPC+blood 0.682706767 0 0.716239316 serum_phospholipids serum_phospholipids 0.00656 0.949 no up no no no no 16:0/22:6-PC+blood 20:4-LPC+blood 0 0.536764706 0 serum_phospholipids serum_phospholipids 4.53E-05 0.949 no up up no no no 16:1/18:1-PG+blood 20:4-LPC+blood 0 -0.50245098 0 serum_phospholipids serum_phospholipids 3.21E-05 0.949 no up up no no no 16:1+blood 20:4-LPC+blood 0 0 -0.416752137 yes serum_fattyacid serum_phospholipids 0.0186 0.949 no no dn no no no 18:0/18:0-PC+blood 20:4-LPC+blood 0 -0.590686275 0 serum_phospholipids serum_phospholipids 0.426 0.949 no no no no no no 18:0/18:0-PE+blood 20:4-LPC+blood 0 -0.558823529 0 serum_phospholipids serum_phospholipids 0.00896 0.949 up up no no no no 18:0/18:1-PC+blood 20:4-LPC+blood 0 -0.575980392 0 serum_phospholipids serum_phospholipids 0.393 0.949 no no no no no no 18:0/18:1-PE+blood 20:4-LPC+blood 0 -0.583333333 0 serum_phospholipids serum_phospholipids 0.00716 0.949 up up no no no no 18:0/18:1-PI+blood 20:4-LPC+blood 0 -0.620098039 0 serum_phospholipids serum_phospholipids 0.599 0.949 no no no no no no 18:0/20:2-PC+blood 20:4-LPC+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.733 0.949 no no no no no no 18:0/20:3-PC+blood 20:4-LPC+blood 0 -0.703431373 0 serum_phospholipids serum_phospholipids 0.0682 0.949 no up no no no no 18:0/20:3-PI+blood 20:4-LPC+blood 0 -0.607843137 0 serum_phospholipids serum_phospholipids 0.377 0.949 no no no no no no 18:0/20:4-PC+blood 20:4-LPC+blood 0.679699248 0.691176471 0.531623932 serum_phospholipids serum_phospholipids 0.454 0.949 no no no no no no 18:0/20:4-PI+blood 20:4-LPC+blood 0.488721805 0 0 serum_phospholipids serum_phospholipids 0.167 0.949 no no no no no no 18:0/20:5-PC+blood 20:4-LPC+blood 0 0.81372549 0 serum_phospholipids serum_phospholipids 0.17 0.949 no no no no no no 18:1/16:0-PE+blood 20:4-LPC+blood 0 -0.590686275 0 serum_phospholipids serum_phospholipids 0.000182 0.949 up up no no no no 18:1/16:0-PI+blood 20:4-LPC+blood 0 -0.632352941 0 serum_phospholipids serum_phospholipids 0.793 0.949 no no no no no no 18:1/16:1-PE+blood 20:4-LPC+blood 0 -0.740196078 0 serum_phospholipids serum_phospholipids 0.000184 0.949 up up no no no no 18:1/18:0-PE+blood 20:4-LPC+blood 0 -0.742647059 0 serum_phospholipids serum_phospholipids 1.39E-06 0.949 up up no no no no 18:1/18:1-PC+blood 20:4-LPC+blood 0 -0.62254902 0 serum_phospholipids serum_phospholipids 1.34E-05 0.949 no up up no no no 18:1/18:1-PE+blood 20:4-LPC+blood 0 -0.742647059 0 serum_phospholipids serum_phospholipids 1.03E-05 0.949 up up no no no no 18:1/18:1-PG+blood 20:4-LPC+blood 0 -0.651960784 0 serum_phospholipids serum_phospholipids 0.00352 0.949 no up up no no no 18:1/18:2-PE+blood 20:4-LPC+blood 0 -0.68627451 0 serum_phospholipids serum_phospholipids 0.000293 0.949 up up no no no no 18:1/18:2-PG+blood 20:4-LPC+blood 0 -0.544117647 0.439316239 serum_phospholipids serum_phospholipids 5.58E-07 0.949 no up up no no no 18:1/20:4-PC+blood 20:4-LPC+blood 0.726315789 0.612745098 0.532307692 serum_phospholipids serum_phospholipids 0.582 0.949 no no no no no no 18:1+blood 20:4-LPC+blood 0 0 -0.401709402 yes serum_fattyacid serum_phospholipids 0.00202 0.949 up no dn no no no 18:2/18:2-PS+blood 20:4-LPC+blood 0 -0.710784314 0 serum_phospholipids serum_phospholipids 0.00674 0.949 up up no no no no 18:2/20:4-PC+blood 20:4-LPC+blood 0 0.534313725 0 serum_phospholipids serum_phospholipids 0.0145 0.949 no no up no no no 18:2n6c+blood 20:4-LPC+blood 0 0 -0.40034188 serum_fattyacid serum_phospholipids 0.15 0.949 no no no no no no 20:0/20:5-PC+blood 20:4-LPC+blood 0.577443609 0 0 serum_phospholipids serum_phospholipids 0.882 0.949 no no no no no no 20:1/20:4-PE+blood 20:4-LPC+blood 0.446616541 0 0 serum_phospholipids serum_phospholipids 0.0042 0.949 up up no no no no 20:2/18:0-PC+blood 20:4-LPC+blood 0 -0.696078431 0 serum_phospholipids serum_phospholipids 0.0427 0.949 no up no no no no 20:2/18:1-PE+blood 20:4-LPC+blood 0 -0.754901961 0 serum_phospholipids serum_phospholipids 0.00208 0.949 up up no no no no 20:3-LPC+blood 20:4-LPC+blood 0 -0.490196078 0 serum_phospholipids serum_phospholipids 0.0292 0.949 no up no no no no 20:3-LPE+blood 20:4-LPC+blood 0 0 0.418119658 serum_phospholipids serum_phospholipids 0.084 0.949 no up no no no no 20:3/16:0-PC+blood 20:4-LPC+blood 0.535338346 0.571078431 0 serum_phospholipids serum_phospholipids 0.00405 0.949 no up up no no no 20:3/18:0-PI+blood 20:4-LPC+blood 0.52481203 0 0 serum_phospholipids serum_phospholipids 0.289 0.949 no no no no no no 20:3n6+blood 20:4-LPC+blood 0 -0.81127451 0 serum_fattyacid serum_phospholipids 0.0884 0.949 up no no no no no Asthma 20:4-LPC+blood 0 0 -0.523076923 kegg serum_phospholipids NA 0.949 no no no no no no Bifidobacterium 20:4-LPC+blood 0.497931588 0 0 acetate-producing Genus serum_phospholipids 0.105 0.949 no dn no no no no Clostridium 20:4-LPC+blood 0 0 0.465525895 Genus serum_phospholipids 0.925 0.949 no no no no no no Epstein-Barr virus infection 20:4-LPC+blood 0 -0.544117647 0 kegg serum_phospholipids NA 0.949 no no no no no no Hematopoietic cell lineage 20:4-LPC+blood 0 0 -0.478461538 kegg serum_phospholipids NA 0.949 no no no no no no Inflammatory bowel disease 20:4-LPC+blood 0 0 -0.516923077 kegg serum_phospholipids NA 0.949 no no no no no no Kaposi sarcoma-associated herpesvirus infection 20:4-LPC+blood 0 -0.5 0 kegg serum_phospholipids NA 0.949 no no dn no no no Leishmaniasis 20:4-LPC+blood 0 0 -0.467692308 kegg serum_phospholipids NA 0.949 no no no no no no MAPK signaling pathway 20:4-LPC+blood 0 0.626470588 0 kegg serum_phospholipids NA 0.949 no no no no no no Ruminococcus 20:4-LPC+blood 0 -0.488044236 0 Genus serum_phospholipids 0.0679 0.949 no no dn no no no Ruminococcus 20:4-LPC+blood 0 -0.482843137 0 acetate-producing Genus serum_phospholipids 0.335 0.949 no no no no no no Systemic lupus erythematosus 20:4-LPC+blood 0 0 -0.443076923 kegg serum_phospholipids NA 0.949 no no no no no no TCA+stool 20:4-LPC+blood 0 -0.727272727 0 stool_bileacids serum_phospholipids 0.458 0.949 no no no no no no Th17 cell differentiation 20:4-LPC+blood 0 0 -0.471538462 kegg serum_phospholipids NA 0.949 no no no no no no Toxoplasmosis 20:4-LPC+blood 0 0 -0.571538462 kegg serum_phospholipids NA 0.949 no no no no no no 12-HEPE+blood 20:4-LPE+blood 0 0 -0.429762271 serum_ARA serum_phospholipids 0.312 0.552 no no no no no no "12,13-EPOME+blood" 20:4-LPE+blood 0 -0.591250338 -0.403115237 serum_ARA serum_phospholipids 0.901 0.552 no no no no no no 14:0-LPC+blood 20:4-LPE+blood -0.457142857 0 0 serum_phospholipids serum_phospholipids 0.00689 0.552 up up no no no no 14:1/18:2-PG+blood 20:4-LPE+blood -0.470676692 0 0 serum_phospholipids serum_phospholipids 0.00259 0.552 no up up no no no 15-HETE+blood 20:4-LPE+blood 0 0 0.454436016 serum_ARA serum_phospholipids 0.819 0.552 no no no no no no 16:0/16:0-PI+blood 20:4-LPE+blood 0 -0.583333333 0 serum_phospholipids serum_phospholipids 0.358 0.552 no no no no no no 16:0/18:1-PE+blood 20:4-LPE+blood 0 -0.49754902 0 serum_phospholipids serum_phospholipids 0.000107 0.552 up up no no no no 16:0/18:2-PI+blood 20:4-LPE+blood -0.497744361 -0.700980392 0 serum_phospholipids serum_phospholipids 0.269 0.552 no no no no no no 16:0/20:4-PC+blood 20:4-LPE+blood 0 0.81372549 0.42017094 serum_phospholipids serum_phospholipids 0.0262 0.552 no up no no no no 16:0/20:4-PI+blood 20:4-LPE+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.558 0.552 no no no no no no 16:0/20:5-PC+blood 20:4-LPE+blood 0 0 -0.442735043 serum_phospholipids serum_phospholipids 0.628 0.552 no no no no no no 16:0/20:5-PG+blood 20:4-LPE+blood 0.593984962 0.590686275 0 serum_phospholipids serum_phospholipids 0.00656 0.552 no up no no no no 16:0/22:6-PC+blood 20:4-LPE+blood 0 0.56127451 0 serum_phospholipids serum_phospholipids 4.53E-05 0.552 no up up no no no 16:0+blood 20:4-LPE+blood 0 0.487745098 0 yes serum_fattyacid serum_phospholipids 0.00876 0.552 up no no no no no 16:1+blood 20:4-LPE+blood 0.473684211 0 0 yes serum_fattyacid serum_phospholipids 0.0186 0.552 no no dn no no no 18:0-LPE+blood 20:4-LPE+blood 0 0 0.404444444 serum_phospholipids serum_phospholipids 0.491 0.552 no no no no no no 18:0/18:0-PE+blood 20:4-LPE+blood 0 -0.735294118 0 serum_phospholipids serum_phospholipids 0.00896 0.552 up up no no no no 18:0/18:1-PE+blood 20:4-LPE+blood 0 -0.801470588 0 serum_phospholipids serum_phospholipids 0.00716 0.552 up up no no no no 18:0/20:4-PC+blood 20:4-LPE+blood 0 0.723039216 0 serum_phospholipids serum_phospholipids 0.454 0.552 no no no no no no 18:0/20:4-PI+blood 20:4-LPE+blood 0.497744361 0.529411765 0 serum_phospholipids serum_phospholipids 0.167 0.552 no no no no no no 18:0/20:5-PC+blood 20:4-LPE+blood 0 0.578431373 0 serum_phospholipids serum_phospholipids 0.17 0.552 no no no no no no 18:0/22:6-PI+blood 20:4-LPE+blood 0 0 -0.45025641 serum_phospholipids serum_phospholipids 0.425 0.552 no no no no no no 18:1-LPC+blood 20:4-LPE+blood 0 0.526960784 0 serum_phospholipids serum_phospholipids 0.179 0.552 no no no no no no 18:1/16:0-PE+blood 20:4-LPE+blood 0 -0.524509804 0 serum_phospholipids serum_phospholipids 0.000182 0.552 up up no no no no 18:1/16:0-PI+blood 20:4-LPE+blood 0 -0.512254902 0 serum_phospholipids serum_phospholipids 0.793 0.552 no no no no no no 18:1/16:1-PE+blood 20:4-LPE+blood 0 -0.517156863 0 serum_phospholipids serum_phospholipids 0.000184 0.552 up up no no no no 18:1/18:0-PE+blood 20:4-LPE+blood 0 -0.593137255 0 serum_phospholipids serum_phospholipids 1.39E-06 0.552 up up no no no no 18:1/18:1-PE+blood 20:4-LPE+blood 0 -0.556372549 0 serum_phospholipids serum_phospholipids 1.03E-05 0.552 up up no no no no 18:1/18:2-PE+blood 20:4-LPE+blood 0 -0.617647059 0 serum_phospholipids serum_phospholipids 0.000293 0.552 up up no no no no 18:1/20:4-PC+blood 20:4-LPE+blood 0.648120301 0.605392157 0 serum_phospholipids serum_phospholipids 0.582 0.552 no no no no no no 18:2/20:4-PC+blood 20:4-LPE+blood 0 0.629901961 0 serum_phospholipids serum_phospholipids 0.0145 0.552 no no up no no no 18:3/16:0-PE+blood 20:4-LPE+blood 0 -0.607843137 0 serum_phospholipids serum_phospholipids 0.00149 0.552 up up no no no no 20:0/20:5-PC+blood 20:4-LPE+blood 0.542857143 0 0 serum_phospholipids serum_phospholipids 0.882 0.552 no no no no no no 20:0+blood 20:4-LPE+blood 0 0.580882353 0 yes serum_fattyacid serum_phospholipids 0.000278 0.552 dn no up no no no 20:1-LPC+blood 20:4-LPE+blood 0 0.514705882 0 serum_phospholipids serum_phospholipids 0.217 0.552 no no no no no no 20:1-LPE+blood 20:4-LPE+blood 0 0.703431373 0 serum_phospholipids serum_phospholipids 0.465 0.552 no no no no no no 20:1/20:4-PE+blood 20:4-LPE+blood 0.512781955 0 0 serum_phospholipids serum_phospholipids 0.0042 0.552 up up no no no no 20:2-LPE+blood 20:4-LPE+blood 0.57593985 0 0 serum_phospholipids serum_phospholipids 0.177 0.552 no no no no no no 20:2/18:1-PE+blood 20:4-LPE+blood 0 -0.575980392 0 serum_phospholipids serum_phospholipids 0.00208 0.552 up up no no no no 20:2/18:3-PE+blood 20:4-LPE+blood 0.6 0 0 serum_phospholipids serum_phospholipids 0.0391 0.552 up up no no no no 20:3-LPE+blood 20:4-LPE+blood 0 0 0.511111111 serum_phospholipids serum_phospholipids 0.084 0.552 no up no no no no 20:3/16:0-PC+blood 20:4-LPE+blood 0 0.784313725 0 serum_phospholipids serum_phospholipids 0.00405 0.552 no up up no no no 20:3/18:0-PI+blood 20:4-LPE+blood 0.502255639 0 0 serum_phospholipids serum_phospholipids 0.289 0.552 no no no no no no 20:4-LPA+blood 20:4-LPE+blood 0.463157895 0 0 serum_phospholipids serum_phospholipids 0.398 0.552 no no no no no no 20:4-LPC+blood 20:4-LPE+blood 0.709774436 0.49754902 0.498803419 serum_phospholipids serum_phospholipids 0.949 0.552 no no no no no no 16:0-LPC+blood 20:4/16:0-PE+blood 0 0 0.456410256 serum_phospholipids serum_phospholipids 0.00456 0.00529 up up no no up up 16:0/18:1-PC+blood 20:4/16:0-PE+blood -0.654135338 0 -0.422222222 serum_phospholipids serum_phospholipids 6.15E-07 0.00529 up up up no up up 16:0/18:1-PE+blood 20:4/16:0-PE+blood 0.598496241 0 0 serum_phospholipids serum_phospholipids 0.000107 0.00529 up up no no up up 16:0/18:2-PC+blood 20:4/16:0-PE+blood -0.6 0 0 serum_phospholipids serum_phospholipids 3.24E-06 0.00529 no up up no up up 16:0/18:2-PI+blood 20:4/16:0-PE+blood 0 0.482843137 0 serum_phospholipids serum_phospholipids 0.269 0.00529 no no no no up up 16:0/20:4-PC+blood 20:4/16:0-PE+blood -0.726315789 -0.575980392 0 serum_phospholipids serum_phospholipids 0.0262 0.00529 no up no no up up 16:0/20:5-PG+blood 20:4/16:0-PE+blood 0 0 -0.42974359 serum_phospholipids serum_phospholipids 0.00656 0.00529 no up no no up up 16:0/22:6-PC+blood 20:4/16:0-PE+blood 0 -0.566176471 0 serum_phospholipids serum_phospholipids 4.53E-05 0.00529 no up up no up up 16:0/22:6-PE+blood 20:4/16:0-PE+blood 0.454135338 0 0 serum_phospholipids serum_phospholipids 0.000934 0.00529 up up no no up up 16:1/16:0-PC+blood 20:4/16:0-PE+blood -0.509774436 -0.583333333 0 serum_phospholipids serum_phospholipids 0.0215 0.00529 no up up no up up 16:1/16:1-PC+blood 20:4/16:0-PE+blood -0.469172932 0 0 serum_phospholipids serum_phospholipids 0.0177 0.00529 no no up no up up 18:0-LPE+blood 20:4/16:0-PE+blood 0.54887218 0 0.490598291 serum_phospholipids serum_phospholipids 0.491 0.00529 no no no no up up 18:0/16:0-PC+blood 20:4/16:0-PE+blood -0.64962406 0 -0.427008547 serum_phospholipids serum_phospholipids 9.64E-07 0.00529 up up up no up up 18:0/18:0-PE+blood 20:4/16:0-PE+blood 0.52481203 0.762254902 0.467350427 serum_phospholipids serum_phospholipids 0.00896 0.00529 up up no no up up 18:0/18:1-PE+blood 20:4/16:0-PE+blood 0.566917293 0.68872549 0.469401709 serum_phospholipids serum_phospholipids 0.00716 0.00529 up up no no up up 18:0/20:4-PC+blood 20:4/16:0-PE+blood -0.685714286 -0.647058824 -0.402393162 serum_phospholipids serum_phospholipids 0.454 0.00529 no no no no up up 18:0/20:5-PC+blood 20:4/16:0-PE+blood -0.503759398 -0.710784314 0 serum_phospholipids serum_phospholipids 0.17 0.00529 no no no no up up 18:0/22:6-PC+blood 20:4/16:0-PE+blood 0 -0.56127451 0 serum_phospholipids serum_phospholipids 0.0775 0.00529 no no up no up up 18:1-LPE+blood 20:4/16:0-PE+blood 0.627067669 0 0.407863248 serum_phospholipids serum_phospholipids 0.117 0.00529 no no no no up up 18:1/16:0-PC+blood 20:4/16:0-PE+blood -0.652631579 0 0 serum_phospholipids serum_phospholipids 2.43E-05 0.00529 no up up no up up 18:1/16:0-PE+blood 20:4/16:0-PE+blood 0.506766917 0.519607843 0 serum_phospholipids serum_phospholipids 0.000182 0.00529 up up no no up up 18:1/16:1-PE+blood 20:4/16:0-PE+blood 0.565413534 0 0 serum_phospholipids serum_phospholipids 0.000184 0.00529 up up no no up up 18:1/18:0-PE+blood 20:4/16:0-PE+blood 0.715789474 0.531862745 0 serum_phospholipids serum_phospholipids 1.39E-06 0.00529 up up no no up up 18:1/18:0-PI+blood 20:4/16:0-PE+blood 0 0.605392157 0 serum_phospholipids serum_phospholipids 0.0931 0.00529 no no up no up up 18:1/18:1-PE+blood 20:4/16:0-PE+blood 0.705263158 0.504901961 0 serum_phospholipids serum_phospholipids 1.03E-05 0.00529 up up no no up up 18:1/18:2-PE+blood 20:4/16:0-PE+blood 0.8 0.696078431 0.535726496 serum_phospholipids serum_phospholipids 0.000293 0.00529 up up no no up up 18:1/18:2-PI+blood 20:4/16:0-PE+blood 0 0 0.535042735 serum_phospholipids serum_phospholipids 0.0164 0.00529 dn no up no up up 18:1/20:4-PC+blood 20:4/16:0-PE+blood -0.57593985 -0.737745098 -0.573333333 serum_phospholipids serum_phospholipids 0.582 0.00529 no no no no up up 18:2-LPA+blood 20:4/16:0-PE+blood -0.505263158 0 0 serum_phospholipids serum_phospholipids 0.00684 0.00529 dn no up no up up 18:2-LPE+blood 20:4/16:0-PE+blood 0.478195489 0 0.436581197 serum_phospholipids serum_phospholipids 0.112 0.00529 no no no no up up 18:2/18:1-PC+blood 20:4/16:0-PE+blood 0 0.691176471 0.545299145 serum_phospholipids serum_phospholipids 2.30E-05 0.00529 dn up up no up up 18:2/18:2-PC+blood 20:4/16:0-PE+blood 0 0.700980392 0.545982906 serum_phospholipids serum_phospholipids 1.98E-05 0.00529 dn up up no up up 18:2/18:2-PS+blood 20:4/16:0-PE+blood 0 0.487745098 0 serum_phospholipids serum_phospholipids 0.00674 0.00529 up up no no up up 18:2/20:4-PC+blood 20:4/16:0-PE+blood -0.464661654 0 0 serum_phospholipids serum_phospholipids 0.0145 0.00529 no no up no up up 18:3/16:0-PE+blood 20:4/16:0-PE+blood 0.559398496 0.754901961 0 serum_phospholipids serum_phospholipids 0.00149 0.00529 up up no no up up 18:3/18:2-PC+blood 20:4/16:0-PE+blood 0 0 0.452991453 serum_phospholipids serum_phospholipids 0.0394 0.00529 no no up no up up 20:0-LPE+blood 20:4/16:0-PE+blood 0.464661654 0 0.572649573 serum_phospholipids serum_phospholipids 0.0615 0.00529 no no up no up up 20:0/20:5-PC+blood 20:4/16:0-PE+blood 0 -0.632352941 0 serum_phospholipids serum_phospholipids 0.882 0.00529 no no no no up up 20:0+blood 20:4/16:0-PE+blood 0 0 0.419487179 yes serum_fattyacid serum_phospholipids 0.000278 0.00529 dn no up no up up 20:1/20:4-PC+blood 20:4/16:0-PE+blood 0 -0.654411765 0 serum_phospholipids serum_phospholipids 0.0419 0.00529 no no up no up up 20:2/18:1-PE+blood 20:4/16:0-PE+blood 0.589473684 0 0 serum_phospholipids serum_phospholipids 0.00208 0.00529 up up no no up up 20:3/16:0-PC+blood 20:4/16:0-PE+blood -0.715789474 -0.524509804 0 serum_phospholipids serum_phospholipids 0.00405 0.00529 no up up no up up 20:4-LPC+blood 20:4/16:0-PE+blood -0.556390977 0 0 serum_phospholipids serum_phospholipids 0.949 0.00529 no no no no up up 20:4-LPE+blood 20:4/16:0-PE+blood 0 -0.512254902 0 serum_phospholipids serum_phospholipids 0.552 0.00529 no no no no up up 12-HEPE+blood 20:4/18:0-PE+blood -0.478947384 0 0 serum_ARA serum_phospholipids 0.312 0.000755 no no no up up no 12-ketoDCA+blood 20:4/18:0-PE+blood 0 -0.497270443 0 serum_bileacids serum_phospholipids 0.517 0.000755 no no no up up no 12-ketoDCA+stool 20:4/18:0-PE+blood 0 0 0.563909774 stool_bileacids serum_phospholipids 0.505 0.000755 no no no up up no 16:0/18:0-PS+blood 20:4/18:0-PE+blood 0.815037594 0.642156863 0.586324786 serum_phospholipids serum_phospholipids 0.377 0.000755 no no no up up no 16:0/18:1-PE+blood 20:4/18:0-PE+blood 0.560902256 0 0.711452991 serum_phospholipids serum_phospholipids 0.000107 0.000755 up up no up up no 16:0/20:4-PE+blood 20:4/18:0-PE+blood 0.780451128 0.605392157 0.889230769 serum_phospholipids serum_phospholipids 0.00139 0.000755 up up no up up no 16:0/22:6-PE+blood 20:4/18:0-PE+blood 0.855639098 0.840686275 0.865299145 serum_phospholipids serum_phospholipids 0.000934 0.000755 up up no up up no 16:1+blood 20:4/18:0-PE+blood 0 0.522058824 0 yes serum_fattyacid serum_phospholipids 0.0186 0.000755 no no dn up up no 18:0-LPA+blood 20:4/18:0-PE+blood 0.618045113 0 0 serum_phospholipids serum_phospholipids 0.0725 0.000755 no dn no up up no 18:0-LPE+blood 20:4/18:0-PE+blood 0.562406015 0 0.469401709 serum_phospholipids serum_phospholipids 0.491 0.000755 no no no up up no 18:0/18:0-PE+blood 20:4/18:0-PE+blood 0.488721805 0 0 serum_phospholipids serum_phospholipids 0.00896 0.000755 up up no up up no 18:0/18:0-PS+blood 20:4/18:0-PE+blood 0.739849624 0.529411765 0.597948718 serum_phospholipids serum_phospholipids 0.00617 0.000755 no up no up up no 18:0/18:1-PE+blood 20:4/18:0-PE+blood 0.508270677 0 0.403076923 serum_phospholipids serum_phospholipids 0.00716 0.000755 up up no up up no 18:0/18:1-PG+blood 20:4/18:0-PE+blood 0.578947368 0 0.493333333 serum_phospholipids serum_phospholipids 0.000842 0.000755 no up no up up no 18:0/18:2-PI+blood 20:4/18:0-PE+blood 0.455639098 0 0 serum_phospholipids serum_phospholipids 0.179 0.000755 no no no up up no 18:0/20:2-PC+blood 20:4/18:0-PE+blood 0 0 -0.431794872 serum_phospholipids serum_phospholipids 0.733 0.000755 no no no up up no 18:0/20:4-PI+blood 20:4/18:0-PE+blood 0 0 0.481025641 serum_phospholipids serum_phospholipids 0.167 0.000755 no no no up up no 18:0/22:6-PE+blood 20:4/18:0-PE+blood 0.682706767 0.759803922 0.718974359 serum_phospholipids serum_phospholipids 0.00022 0.000755 up up no up up no 18:1/16:0-PE+blood 20:4/18:0-PE+blood 0.612030075 0 0.688205128 serum_phospholipids serum_phospholipids 0.000182 0.000755 up up no up up no 18:1/16:1-PE+blood 20:4/18:0-PE+blood 0.545864662 0 0.727179487 serum_phospholipids serum_phospholipids 0.000184 0.000755 up up no up up no 18:1/18:0-PE+blood 20:4/18:0-PE+blood 0.715789474 0 0.718974359 serum_phospholipids serum_phospholipids 1.39E-06 0.000755 up up no up up no 18:1/18:0-PS+blood 20:4/18:0-PE+blood 0 0.514705882 0 serum_phospholipids serum_phospholipids 0.193 0.000755 no no no up up no 18:1/18:1-PC+blood 20:4/18:0-PE+blood -0.467669173 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.000755 no up up up up no 18:1/18:1-PE+blood 20:4/18:0-PE+blood 0.735338346 0.485294118 0.718974359 serum_phospholipids serum_phospholipids 1.03E-05 0.000755 up up no up up no 18:1/18:2-PE+blood 20:4/18:0-PE+blood 0.494736842 0 0.606153846 serum_phospholipids serum_phospholipids 0.000293 0.000755 up up no up up no 18:1/20:3-PC+blood 20:4/18:0-PE+blood -0.460150376 0 0 serum_phospholipids serum_phospholipids 0.00872 0.000755 no up up up up no 18:1/20:4-PE+blood 20:4/18:0-PE+blood 0.834586466 0.867647059 0.855042735 serum_phospholipids serum_phospholipids 0.0578 0.000755 up no no up up no 18:1/22:6-PE+blood 20:4/18:0-PE+blood 0.62406015 0.578431373 0.435213675 serum_phospholipids serum_phospholipids 0.0047 0.000755 no up no up up no 18:1+blood 20:4/18:0-PE+blood 0 0 0.415384615 yes serum_fattyacid serum_phospholipids 0.00202 0.000755 up no dn up up no 18:2-LPC+blood 20:4/18:0-PE+blood 0 0 -0.434529915 serum_phospholipids serum_phospholipids 0.00743 0.000755 dn no up up up no 18:2/18:2-PS+blood 20:4/18:0-PE+blood 0.604511278 0 0 serum_phospholipids serum_phospholipids 0.00674 0.000755 up up no up up no 18:3-LPC+blood 20:4/18:0-PE+blood 0 0 -0.571965812 serum_phospholipids serum_phospholipids 0.147 0.000755 no no no up up no 18:3/16:0-PE+blood 20:4/18:0-PE+blood 0.542857143 0 0 serum_phospholipids serum_phospholipids 0.00149 0.000755 up up no up up no 20:0/20:4-PE+blood 20:4/18:0-PE+blood 0.751879699 0 0.598632479 serum_phospholipids serum_phospholipids 0.00128 0.000755 up up no up up no 20:1/20:4-PE+blood 20:4/18:0-PE+blood 0.760902256 0.730392157 0.744273504 serum_phospholipids serum_phospholipids 0.0042 0.000755 up up no up up no 20:1+blood 20:4/18:0-PE+blood 0 0 -0.407863248 yes serum_fattyacid serum_phospholipids 2.56E-05 0.000755 dn dn dn up up no 20:2-LPC+blood 20:4/18:0-PE+blood 0 0 -0.429059829 serum_phospholipids serum_phospholipids 0.119 0.000755 no no up up up no 20:2/18:1-PE+blood 20:4/18:0-PE+blood 0.664661654 0 0.651965812 serum_phospholipids serum_phospholipids 0.00208 0.000755 up up no up up no 20:2/18:3-PE+blood 20:4/18:0-PE+blood 0.741353383 0.75 0.796239316 serum_phospholipids serum_phospholipids 0.0391 0.000755 up up no up up no 20:3/18:0-PI+blood 20:4/18:0-PE+blood 0 0 0.45982906 serum_phospholipids serum_phospholipids 0.289 0.000755 no no no up up no Alcoholism 20:4/18:0-PE+blood 0 0.620588235 0 kegg serum_phospholipids NA 0.000755 no no no up up no Aldosterone synthesis and secretion 20:4/18:0-PE+blood -0.456140351 0 0 kegg serum_phospholipids NA 0.000755 no up up up up no Axon guidance 20:4/18:0-PE+blood 0 0 0.534615385 kegg serum_phospholipids NA 0.000755 no up up up up no Calcium signaling pathway 20:4/18:0-PE+blood -0.471929825 0 0 kegg serum_phospholipids NA 0.000755 no up up up up no cGMP-PKG signaling pathway 20:4/18:0-PE+blood 0 0 0.640769231 kegg serum_phospholipids NA 0.000755 no no no up up no Cholinergic synapse 20:4/18:0-PE+blood 0 0.641176471 0 kegg serum_phospholipids NA 0.000755 no no no up up no Cytosolic DNA-sensing pathway 20:4/18:0-PE+blood 0 -0.573529412 0 kegg serum_phospholipids NA 0.000755 no no no up up no Epithelial cell signaling in Helicobacter pylori infection 20:4/18:0-PE+blood 0 0 0.421538462 kegg serum_phospholipids NA 0.000755 no no no up up no Fc gamma R-mediated phagocytosis 20:4/18:0-PE+blood 0.5 0 0.422307692 kegg serum_phospholipids NA 0.000755 no no no up up no Ferroptosis 20:4/18:0-PE+blood -0.494736842 0 0 kegg serum_phospholipids NA 0.000755 no no no up up no GDCA+stool 20:4/18:0-PE+blood 0 -0.665149789 0 stool_bileacids serum_phospholipids 0.656 0.000755 no no no up up no Glioma 20:4/18:0-PE+blood 0 0 0.433846154 kegg serum_phospholipids NA 0.000755 no no no up up no GnRH signaling pathway 20:4/18:0-PE+blood -0.533333333 0 0 kegg serum_phospholipids NA 0.000755 no no no up up no Hepatitis C 20:4/18:0-PE+blood 0 -0.605882353 0 kegg serum_phospholipids NA 0.000755 no no no up up no Intestinal immune network for IgA production 20:4/18:0-PE+blood -0.622807018 0 0 kegg serum_phospholipids NA 0.000755 no no no up up no Kaposi sarcoma-associated herpesvirus infection 20:4/18:0-PE+blood -0.687719298 0 0 kegg serum_phospholipids NA 0.000755 no no dn up up no L-Phenylalanine+stool 20:4/18:0-PE+blood 0.71978022 0 0 stool_cometabolism serum_phospholipids 0.398 0.000755 no no no up up no L-Tryptophan+stool 20:4/18:0-PE+blood 0.653846154 0 0 stool_cometabolism serum_phospholipids 0.557 0.000755 no no no up up no L-Tyrosine+stool 20:4/18:0-PE+blood 0.587912088 0 0 stool_cometabolism serum_phospholipids 0.44 0.000755 no no no up up no LCA+stool 20:4/18:0-PE+blood 0 0 0.493233083 stool_bileacids serum_phospholipids 0.314 0.000755 no no no up up no Lipid and atherosclerosis 20:4/18:0-PE+blood 0 0 0.476923077 kegg serum_phospholipids NA 0.000755 no no no up up no Longevity regulating pathway - multiple species 20:4/18:0-PE+blood 0.514035088 0 0 kegg serum_phospholipids NA 0.000755 no no no up up no MAPK signaling pathway 20:4/18:0-PE+blood 0.468421053 0 0.417692308 kegg serum_phospholipids NA 0.000755 no no no up up no Measles 20:4/18:0-PE+blood 0 -0.576470588 0 kegg serum_phospholipids NA 0.000755 no no no up up no Mineral absorption 20:4/18:0-PE+blood -0.496491228 0 0 kegg serum_phospholipids NA 0.000755 no no no up up no Mitophagy - animal 20:4/18:0-PE+blood -0.505263158 0 0 kegg serum_phospholipids NA 0.000755 no no no up up no Necroptosis 20:4/18:0-PE+blood -0.505263158 0 0 kegg serum_phospholipids NA 0.000755 no no no up up no Olfactory transduction 20:4/18:0-PE+blood 0.531578947 0 0 kegg serum_phospholipids NA 0.000755 no no no up up no Osteoclast differentiation 20:4/18:0-PE+blood 0 0 0.468461538 kegg serum_phospholipids NA 0.000755 no no no up up no Pertussis 20:4/18:0-PE+blood 0 0 0.475384615 kegg serum_phospholipids NA 0.000755 no no dn up up no PPAR signaling pathway 20:4/18:0-PE+blood 0 0 0.737692308 kegg serum_phospholipids NA 0.000755 no no no up up no Prevotella 20:4/18:0-PE+blood 0 0.520633347 0 acetate-producing Genus serum_phospholipids 0.287 0.000755 no no no up up no Primary immunodeficiency 20:4/18:0-PE+blood 0.521052632 0 0 kegg serum_phospholipids NA 0.000755 no no no up up no Relaxin signaling pathway 20:4/18:0-PE+blood -0.50877193 0 0 kegg serum_phospholipids NA 0.000755 no no no up up no Salivary secretion 20:4/18:0-PE+blood 0 0.664705882 0 kegg serum_phospholipids NA 0.000755 no no no up up no Salmonella infection 20:4/18:0-PE+blood 0.566666667 0 0 kegg serum_phospholipids NA 0.000755 no no no up up no Serotonergic synapse 20:4/18:0-PE+blood 0 0.5 0 kegg serum_phospholipids NA 0.000755 no no no up up no Shigellosis 20:4/18:0-PE+blood -0.498245614 0 0 kegg serum_phospholipids NA 0.000755 no no no up up no Slackia 20:4/18:0-PE+blood 0 0 -0.400945841 Genus serum_phospholipids 0.94 0.000755 no no no up up no T cell receptor signaling pathway 20:4/18:0-PE+blood 0 -0.561764706 0 kegg serum_phospholipids NA 0.000755 no no no up up no Th1 and Th2 cell differentiation 20:4/18:0-PE+blood 0 -0.526470588 0 kegg serum_phospholipids NA 0.000755 no no no up up no Th17 cell differentiation 20:4/18:0-PE+blood 0 -0.620588235 0 kegg serum_phospholipids NA 0.000755 no no no up up no Thyroid hormone synthesis 20:4/18:0-PE+blood -0.466666667 0 0 kegg serum_phospholipids NA 0.000755 no no no up up no Toll-like receptor signaling pathway 20:4/18:0-PE+blood 0 0 0.457692308 yes kegg serum_phospholipids NA 0.000755 no no no up up no 14:0/18:0-PC+blood 20:4n6+blood 0 -0.583333333 0 serum_phospholipids serum_fattyacid 0.00289 0.133 up up no no no no 16:0-LPC+blood 20:4n6+blood 0 0 -0.507692308 serum_phospholipids serum_fattyacid 0.00456 0.133 up up no no no no 16:0/16:0-PI+blood 20:4n6+blood 0 -0.659313725 0 serum_phospholipids serum_fattyacid 0.358 0.133 no no no no no no 16:0/16:1-PC+blood 20:4n6+blood 0 -0.605392157 0 serum_phospholipids serum_fattyacid 0.00283 0.133 up up no no no no 16:0/16:1-PI+blood 20:4n6+blood 0 -0.588235294 0 serum_phospholipids serum_fattyacid 0.262 0.133 no no no no no no 16:0/18:1-PE+blood 20:4n6+blood 0 -0.504901961 0 serum_phospholipids serum_fattyacid 0.000107 0.133 up up no no no no 16:0/18:2-PI+blood 20:4n6+blood -0.446616541 -0.649509804 0 serum_phospholipids serum_fattyacid 0.269 0.133 no no no no no no 16:0/20:4-PC+blood 20:4n6+blood 0.584962406 0.757352941 0.572649573 serum_phospholipids serum_fattyacid 0.0262 0.133 no up no no no no 16:0/20:5-PC+blood 20:4n6+blood 0 0.571078431 0 serum_phospholipids serum_fattyacid 0.628 0.133 no no no no no no 16:0/20:5-PG+blood 20:4n6+blood 0.705263158 0.482843137 0.512478632 serum_phospholipids serum_fattyacid 0.00656 0.133 no up no no no no 16:0/22:6-PC+blood 20:4n6+blood 0 0.644607843 0 serum_phospholipids serum_fattyacid 4.53E-05 0.133 no up up no no no 16:0+blood 20:4n6+blood 0 0.526960784 0 yes serum_fattyacid serum_fattyacid 0.00876 0.133 up no no no no no 16:1/16:1-PC+blood 20:4n6+blood 0.446616541 0 0 serum_phospholipids serum_fattyacid 0.0177 0.133 no no up no no no 18:0/18:0-PE+blood 20:4n6+blood 0 -0.612745098 0 serum_phospholipids serum_fattyacid 0.00896 0.133 up up no no no no 18:0/18:1-PE+blood 20:4n6+blood 0 -0.676470588 0 serum_phospholipids serum_fattyacid 0.00716 0.133 up up no no no no 18:0/18:1-PI+blood 20:4n6+blood 0 -0.605392157 0 serum_phospholipids serum_fattyacid 0.599 0.133 no no no no no no 18:0/20:3-PC+blood 20:4n6+blood 0 -0.529411765 0 serum_phospholipids serum_fattyacid 0.0682 0.133 no up no no no no 18:0/20:4-PC+blood 20:4n6+blood 0.678195489 0.776960784 0.684102564 serum_phospholipids serum_fattyacid 0.454 0.133 no no no no no no 18:0/20:4-PI+blood 20:4n6+blood 0.553383459 0 0 serum_phospholipids serum_fattyacid 0.167 0.133 no no no no no no 18:0/20:5-PC+blood 20:4n6+blood 0 0.786764706 0 serum_phospholipids serum_fattyacid 0.17 0.133 no no no no no no 18:0+blood 20:4n6+blood 0 0 0.575384615 serum_fattyacid serum_fattyacid 0.344 0.133 no no no no no no 18:1/16:0-PE+blood 20:4n6+blood 0 -0.504901961 0 serum_phospholipids serum_fattyacid 0.000182 0.133 up up no no no no 18:1/16:0-PI+blood 20:4n6+blood 0 -0.713235294 0 serum_phospholipids serum_fattyacid 0.793 0.133 no no no no no no 18:1/16:1-PE+blood 20:4n6+blood 0 -0.512254902 0 serum_phospholipids serum_fattyacid 0.000184 0.133 up up no no no no 18:1/18:0-PE+blood 20:4n6+blood 0 -0.571078431 0 serum_phospholipids serum_fattyacid 1.39E-06 0.133 up up no no no no 18:1/18:0-PS+blood 20:4n6+blood 0 0 0.422222222 serum_phospholipids serum_fattyacid 0.193 0.133 no no no no no no 18:1/18:1-PE+blood 20:4n6+blood 0 -0.519607843 0 serum_phospholipids serum_fattyacid 1.03E-05 0.133 up up no no no no 18:1/18:1-PI+blood 20:4n6+blood 0 -0.573529412 0 serum_phospholipids serum_fattyacid 0.111 0.133 dn no no no no no 18:1/18:2-PE+blood 20:4n6+blood 0 -0.634803922 0 serum_phospholipids serum_fattyacid 0.000293 0.133 up up no no no no 18:1/20:4-PC+blood 20:4n6+blood 0.780451128 0.605392157 0.665641026 serum_phospholipids serum_fattyacid 0.582 0.133 no no no no no no 18:1/20:4-PI+blood 20:4n6+blood 0 0 0.608205128 serum_phospholipids serum_fattyacid 0.192 0.133 no no no no no no 18:2-LPC+blood 20:4n6+blood 0 0 -0.403076923 serum_phospholipids serum_fattyacid 0.00743 0.133 dn no up no no no 18:2-LPE+blood 20:4n6+blood -0.505263158 0 -0.474188034 serum_phospholipids serum_fattyacid 0.112 0.133 no no no no no no 18:2/20:4-PC+blood 20:4n6+blood 0 0.536764706 0 serum_phospholipids serum_fattyacid 0.0145 0.133 no no up no no no 18:3/16:0-PE+blood 20:4n6+blood 0 -0.492647059 0 serum_phospholipids serum_fattyacid 0.00149 0.133 up up no no no no 20:0-LPE+blood 20:4n6+blood 0 -0.541666667 0 serum_phospholipids serum_fattyacid 0.0615 0.133 no no up no no no 20:0/20:4-PE+blood 20:4n6+blood 0.481203008 0 0 serum_phospholipids serum_fattyacid 0.00128 0.133 up up no no no no 20:0/20:5-PC+blood 20:4n6+blood 0.618045113 0 0 serum_phospholipids serum_fattyacid 0.882 0.133 no no no no no no 20:1/20:4-PE+blood 20:4n6+blood 0.604511278 0 0 serum_phospholipids serum_fattyacid 0.0042 0.133 up up no no no no 20:2/18:0-PC+blood 20:4n6+blood 0 -0.524509804 0 serum_phospholipids serum_fattyacid 0.0427 0.133 no up no no no no 20:2/18:1-PE+blood 20:4n6+blood 0 -0.590686275 0 serum_phospholipids serum_fattyacid 0.00208 0.133 up up no no no no 20:2/18:3-PE+blood 20:4n6+blood 0.49924812 0 0 serum_phospholipids serum_fattyacid 0.0391 0.133 up up no no no no 20:3/16:0-PC+blood 20:4n6+blood 0.511278195 0.776960784 0.530940171 serum_phospholipids serum_fattyacid 0.00405 0.133 no up up no no no 20:3/18:0-PI+blood 20:4n6+blood 0.57593985 0 0 serum_phospholipids serum_fattyacid 0.289 0.133 no no no no no no 20:4-LPA+blood 20:4n6+blood 0.532330827 0 0 serum_phospholipids serum_fattyacid 0.398 0.133 no no no no no no 20:4-LPC+blood 20:4n6+blood 0.780451128 0.693627451 0.658803419 serum_phospholipids serum_fattyacid 0.949 0.133 no no no no no no 20:4-LPE+blood 20:4n6+blood 0.72481203 0.725490196 0 serum_phospholipids serum_fattyacid 0.552 0.133 no no no no no no 20:4/16:0-PE+blood 20:4n6+blood 0 0 -0.442051282 serum_phospholipids serum_fattyacid 0.00529 0.133 no up up no no no ACA+stool 20:4n6+blood 0 0 -0.637329274 stool_bileacids serum_fattyacid 0.417 0.133 no no no no no no Cholinergic synapse 20:4n6+blood 0 0.629411765 0 kegg serum_fattyacid NA 0.133 no no no no no no Clostridium 20:4n6+blood -0.514479164 0 0 Genus serum_fattyacid 0.925 0.133 no no no no no no GnRH signaling pathway 20:4n6+blood -0.51754386 0 0 kegg serum_fattyacid NA 0.133 no no no no no no Kaposi sarcoma-associated herpesvirus infection 20:4n6+blood 0 -0.561764706 0 kegg serum_fattyacid NA 0.133 no no dn no no no MAPK signaling pathway 20:4n6+blood 0 0.629411765 0 kegg serum_fattyacid NA 0.133 no no no no no no Mitophagy - animal 20:4n6+blood 0 -0.573529412 0 kegg serum_fattyacid NA 0.133 no no no no no no Paraprevotella 20:4n6+blood 0.518519556 0 0 Genus serum_fattyacid 0.118 0.133 no no no no no no Parkinson disease 20:4n6+blood 0 -0.555882353 0 kegg serum_fattyacid NA 0.133 no no no no no no Pathways of neurodegeneration - multiple diseases 20:4n6+blood 0 -0.558823529 0 kegg serum_fattyacid NA 0.133 no no no no no no Porphyrin and chlorophyll metabolism 20:4n6+blood 0 -0.591176471 0 kegg serum_fattyacid NA 0.133 no no no no no no Renal cell carcinoma 20:4n6+blood 0 -0.502941176 0 kegg serum_fattyacid NA 0.133 no no no no no no Ruminococcus 20:4n6+blood 0 -0.56372549 0 acetate-producing Genus serum_fattyacid 0.335 0.133 no no no no no no Shigellosis 20:4n6+blood 0 -0.658823529 0 kegg serum_fattyacid NA 0.133 no no no no no no Ubiquitin mediated proteolysis 20:4n6+blood 0 -0.567647059 0 kegg serum_fattyacid NA 0.133 no no no no no no 14:0/18:0-PC+blood 20:5-LPC+blood 0 -0.593137255 0 serum_phospholipids serum_phospholipids 0.00289 0.558 up up no no no no 16:0/16:1-PC+blood 20:5-LPC+blood 0 -0.590686275 0 serum_phospholipids serum_phospholipids 0.00283 0.558 up up no no no no 16:0/16:1-PI+blood 20:5-LPC+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.262 0.558 no no no no no no 16:0/18:1-PE+blood 20:5-LPC+blood 0 -0.49754902 0 serum_phospholipids serum_phospholipids 0.000107 0.558 up up no no no no 16:0/20:3-PC+blood 20:5-LPC+blood 0 -0.595588235 -0.50974359 serum_phospholipids serum_phospholipids 5.43E-06 0.558 no up up no no no 16:0/20:5-PC+blood 20:5-LPC+blood 0.945864662 0.772058824 0.785982906 serum_phospholipids serum_phospholipids 0.628 0.558 no no no no no no 16:0/22:0-PE+blood 20:5-LPC+blood 0 0.50245098 0 serum_phospholipids serum_phospholipids 0.00839 0.558 dn no up no no no 16:0/22:6-PC+blood 20:5-LPC+blood 0 0.492647059 0 serum_phospholipids serum_phospholipids 4.53E-05 0.558 no up up no no no 16:1/18:1-PG+blood 20:5-LPC+blood 0 -0.607843137 0 serum_phospholipids serum_phospholipids 3.21E-05 0.558 no up up no no no 18:0-LPE+blood 20:5-LPC+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.491 0.558 no no no no no no 18:0/18:1-PI+blood 20:5-LPC+blood 0 -0.573529412 0 serum_phospholipids serum_phospholipids 0.599 0.558 no no no no no no 18:0/18:2-PI+blood 20:5-LPC+blood -0.533834586 0 0 serum_phospholipids serum_phospholipids 0.179 0.558 no no no no no no 18:0/20:2-PC+blood 20:5-LPC+blood 0 -0.526960784 0 serum_phospholipids serum_phospholipids 0.733 0.558 no no no no no no 18:0/20:3-PC+blood 20:5-LPC+blood 0 -0.637254902 0 serum_phospholipids serum_phospholipids 0.0682 0.558 no up no no no no 18:0/20:3-PI+blood 20:5-LPC+blood -0.557894737 -0.661764706 0 serum_phospholipids serum_phospholipids 0.377 0.558 no no no no no no 18:0/20:4-PC+blood 20:5-LPC+blood 0 0.482843137 0 serum_phospholipids serum_phospholipids 0.454 0.558 no no no no no no 18:0/20:4-PI+blood 20:5-LPC+blood -0.460150376 0 0 serum_phospholipids serum_phospholipids 0.167 0.558 no no no no no no 18:0/20:5-PC+blood 20:5-LPC+blood 0 0.602941176 0 serum_phospholipids serum_phospholipids 0.17 0.558 no no no no no no 18:0/22:6-PC+blood 20:5-LPC+blood 0 0 0.437948718 serum_phospholipids serum_phospholipids 0.0775 0.558 no no up no no no 18:1-LPC+blood 20:5-LPC+blood -0.618045113 0 0 serum_phospholipids serum_phospholipids 0.179 0.558 no no no no no no 18:1/16:0-PI+blood 20:5-LPC+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.793 0.558 no no no no no no 18:1/16:1-PE+blood 20:5-LPC+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.000184 0.558 up up no no no no 18:1/18:0-PI+blood 20:5-LPC+blood -0.572932331 0 0 serum_phospholipids serum_phospholipids 0.0931 0.558 no no up no no no 18:1/18:1-PC+blood 20:5-LPC+blood 0 -0.703431373 -0.541196581 serum_phospholipids serum_phospholipids 1.34E-05 0.558 no up up no no no 18:1/18:1-PG+blood 20:5-LPC+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.00352 0.558 no up up no no no 18:1/18:1-PI+blood 20:5-LPC+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.111 0.558 dn no no no no no 18:1/18:2-PI+blood 20:5-LPC+blood -0.527819549 0 0 serum_phospholipids serum_phospholipids 0.0164 0.558 dn no up no no no 18:1/20:3-PC+blood 20:5-LPC+blood 0 -0.715686275 -0.502905983 serum_phospholipids serum_phospholipids 0.00872 0.558 no up up no no no 18:2-LPE+blood 20:5-LPC+blood 0 -0.50245098 0 serum_phospholipids serum_phospholipids 0.112 0.558 no no no no no no 18:2/18:2-PS+blood 20:5-LPC+blood 0 -0.5 0 serum_phospholipids serum_phospholipids 0.00674 0.558 up up no no no no 18:3-LPC+blood 20:5-LPC+blood 0 0.651960784 0.458461538 serum_phospholipids serum_phospholipids 0.147 0.558 no no no no no no 18:3n3+blood 20:5-LPC+blood 0 0.634803922 0 serum_fattyacid serum_phospholipids 0.291 0.558 no no no no no no 20:0/20:4-PE+blood 20:5-LPC+blood 0 0 -0.489230769 serum_phospholipids serum_phospholipids 0.00128 0.558 up up no no no no 20:1/20:4-PE+blood 20:5-LPC+blood -0.448120301 0 0 serum_phospholipids serum_phospholipids 0.0042 0.558 up up no no no no 20:2-LPC+blood 20:5-LPC+blood -0.613533835 0 0 serum_phospholipids serum_phospholipids 0.119 0.558 no no up no no no 20:2/18:0-PC+blood 20:5-LPC+blood 0 -0.629901961 0 serum_phospholipids serum_phospholipids 0.0427 0.558 no up no no no no 20:2/18:1-PE+blood 20:5-LPC+blood 0 -0.482843137 0 serum_phospholipids serum_phospholipids 0.00208 0.558 up up no no no no 20:2+blood 20:5-LPC+blood -0.593984962 -0.539215686 0 serum_fattyacid serum_phospholipids 0.478 0.558 no no no no no no 20:3-LPC+blood 20:5-LPC+blood 0 -0.661764706 0 serum_phospholipids serum_phospholipids 0.0292 0.558 no up no no no no 20:3-LPE+blood 20:5-LPC+blood 0 -0.720588235 0 serum_phospholipids serum_phospholipids 0.084 0.558 no up no no no no 20:3n6+blood 20:5-LPC+blood 0 -0.75 0 serum_fattyacid serum_phospholipids 0.0884 0.558 up no no no no no 20:4-LPC+blood 20:5-LPC+blood 0 0.727941176 0 serum_phospholipids serum_phospholipids 0.949 0.558 no no no no no no 20:4n6+blood 20:5-LPC+blood 0 0.649509804 0 serum_fattyacid serum_phospholipids 0.133 0.558 no no no no no no 14:0-LPC+blood 20:5/18:0-PC+blood 0 -0.56372549 0 serum_phospholipids serum_phospholipids 0.00689 3.97E-06 up up no no up up 14:0/18:0-PC+blood 20:5/18:0-PC+blood 0 -0.49754902 0 serum_phospholipids serum_phospholipids 0.00289 3.97E-06 up up no no up up 14:0/20:4-PC+blood 20:5/18:0-PC+blood 0 0 -0.428376068 serum_phospholipids serum_phospholipids 0.486 3.97E-06 no no no no up up 16:0/14:0-PC+blood 20:5/18:0-PC+blood 0 0 0.533675214 serum_phospholipids serum_phospholipids 0.0206 3.97E-06 no up up no up up 16:0/16:0-PC+blood 20:5/18:0-PC+blood 0.563909774 0 0 serum_phospholipids serum_phospholipids 0.00079 3.97E-06 no up up no up up 16:0/16:0-PI+blood 20:5/18:0-PC+blood 0 -0.68627451 0 serum_phospholipids serum_phospholipids 0.358 3.97E-06 no no no no up up 16:0/16:1-PI+blood 20:5/18:0-PC+blood 0 -0.568627451 0 serum_phospholipids serum_phospholipids 0.262 3.97E-06 no no no no up up 16:0/18:0-PC+blood 20:5/18:0-PC+blood 0.47518797 0 0.457094017 serum_phospholipids serum_phospholipids 0.521 3.97E-06 no no no no up up 16:0/18:1-PC+blood 20:5/18:0-PC+blood 0 0.68872549 0.487179487 serum_phospholipids serum_phospholipids 6.15E-07 3.97E-06 up up up no up up 16:0/18:2-PC+blood 20:5/18:0-PC+blood 0.615037594 0.556372549 0.766837607 serum_phospholipids serum_phospholipids 3.24E-06 3.97E-06 no up up no up up 16:0/18:2-PI+blood 20:5/18:0-PC+blood 0 -0.617647059 0 serum_phospholipids serum_phospholipids 0.269 3.97E-06 no no no no up up 16:0/20:3-PC+blood 20:5/18:0-PC+blood 0.54887218 0 0 serum_phospholipids serum_phospholipids 5.43E-06 3.97E-06 no up up no up up 16:0/20:4-PC+blood 20:5/18:0-PC+blood 0 0.745098039 0 serum_phospholipids serum_phospholipids 0.0262 3.97E-06 no up no no up up 16:0/20:4-PI+blood 20:5/18:0-PC+blood 0 -0.509803922 0 serum_phospholipids serum_phospholipids 0.558 3.97E-06 no no no no up up 16:0/22:0-PE+blood 20:5/18:0-PC+blood 0.738345865 0.598039216 0.602735043 serum_phospholipids serum_phospholipids 0.00839 3.97E-06 dn no up no up up 16:0/22:6-PC+blood 20:5/18:0-PC+blood 0.918796992 0.963235294 0.90974359 serum_phospholipids serum_phospholipids 4.53E-05 3.97E-06 no up up no up up 16:1/16:0-PC+blood 20:5/18:0-PC+blood 0.681203008 0.81372549 0.621880342 serum_phospholipids serum_phospholipids 0.0215 3.97E-06 no up up no up up 16:1/16:1-PC+blood 20:5/18:0-PC+blood 0.535338346 0.610294118 0.404444444 serum_phospholipids serum_phospholipids 0.0177 3.97E-06 no no up no up up 18:0/16:0-PC+blood 20:5/18:0-PC+blood 0.446616541 0.68872549 0.452991453 serum_phospholipids serum_phospholipids 9.64E-07 3.97E-06 up up up no up up 18:0/18:0-PE+blood 20:5/18:0-PC+blood 0 -0.568627451 0 serum_phospholipids serum_phospholipids 0.00896 3.97E-06 up up no no up up 18:0/18:1-PE+blood 20:5/18:0-PC+blood 0 -0.625 0 serum_phospholipids serum_phospholipids 0.00716 3.97E-06 up up no no up up 18:0/18:1-PG+blood 20:5/18:0-PC+blood 0 0 -0.632820513 serum_phospholipids serum_phospholipids 0.000842 3.97E-06 no up no no up up 18:0/18:2-PC+blood 20:5/18:0-PC+blood 0.696240602 0 0.797606838 serum_phospholipids serum_phospholipids 1.74E-06 3.97E-06 no up up no up up 18:0/20:4-PC+blood 20:5/18:0-PC+blood 0 0.825980392 0 serum_phospholipids serum_phospholipids 0.454 3.97E-06 no no no no up up 18:0/20:5-PC+blood 20:5/18:0-PC+blood 0.544360902 0.659313725 0 serum_phospholipids serum_phospholipids 0.17 3.97E-06 no no no no up up 18:0/22:6-PA+blood 20:5/18:0-PC+blood 0.454135338 0.529411765 0 serum_phospholipids serum_phospholipids 0.22 3.97E-06 no no no no up up 18:0/22:6-PC+blood 20:5/18:0-PC+blood 0.839097744 0.727941176 0.680683761 serum_phospholipids serum_phospholipids 0.0775 3.97E-06 no no up no up up 18:0/22:6-PI+blood 20:5/18:0-PC+blood 0.460150376 0.509803922 0 serum_phospholipids serum_phospholipids 0.425 3.97E-06 no no no no up up 18:1-LPE+blood 20:5/18:0-PC+blood -0.615037594 0 0 serum_phospholipids serum_phospholipids 0.117 3.97E-06 no no no no up up 18:1/16:0-PC+blood 20:5/18:0-PC+blood 0.603007519 0.568627451 0.761367521 serum_phospholipids serum_phospholipids 2.43E-05 3.97E-06 no up up no up up 18:1/16:0-PE+blood 20:5/18:0-PC+blood -0.636090226 -0.512254902 0 serum_phospholipids serum_phospholipids 0.000182 3.97E-06 up up no no up up 18:1/16:0-PI+blood 20:5/18:0-PC+blood 0 -0.637254902 0 serum_phospholipids serum_phospholipids 0.793 3.97E-06 no no no no up up 18:1/18:0-PC+blood 20:5/18:0-PC+blood 0.678195489 0 0.794871795 serum_phospholipids serum_phospholipids 1.83E-06 3.97E-06 no up up no up up 18:1/18:0-PE+blood 20:5/18:0-PC+blood 0 -0.575980392 0 serum_phospholipids serum_phospholipids 1.39E-06 3.97E-06 up up no no up up 18:1/18:2-PE+blood 20:5/18:0-PC+blood -0.470676692 -0.600490196 0 serum_phospholipids serum_phospholipids 0.000293 3.97E-06 up up no no up up 18:1/20:4-PC+blood 20:5/18:0-PC+blood 0 0.700980392 0 serum_phospholipids serum_phospholipids 0.582 3.97E-06 no no no no up up 18:1/22:6-PE+blood 20:5/18:0-PC+blood 0 0 0.56034188 serum_phospholipids serum_phospholipids 0.0047 3.97E-06 no up no no up up 18:2/16:0-PC+blood 20:5/18:0-PC+blood 0.606015038 0.534313725 0.548717949 serum_phospholipids serum_phospholipids 8.67E-05 3.97E-06 no up up no up up 18:2/20:4-PC+blood 20:5/18:0-PC+blood 0.464661654 0 0 serum_phospholipids serum_phospholipids 0.0145 3.97E-06 no no up no up up 18:3/16:0-PE+blood 20:5/18:0-PC+blood -0.487218045 -0.590686275 0 serum_phospholipids serum_phospholipids 0.00149 3.97E-06 up up no no up up 18:3n3+blood 20:5/18:0-PC+blood 0.532330827 0 0 serum_fattyacid serum_phospholipids 0.291 3.97E-06 no no no no up up 18:3n6+blood 20:5/18:0-PC+blood 0 0 -0.423589744 serum_fattyacid serum_phospholipids 0.0463 3.97E-06 up no dn no up up 20:0-LPE+blood 20:5/18:0-PC+blood -0.458646617 0 0 serum_phospholipids serum_phospholipids 0.0615 3.97E-06 no no up no up up 20:0/20:4-PE+blood 20:5/18:0-PC+blood -0.476691729 -0.74754902 -0.414700855 serum_phospholipids serum_phospholipids 0.00128 3.97E-06 up up no no up up 20:1/20:4-PC+blood 20:5/18:0-PC+blood 0.876691729 0.727941176 0.763418803 serum_phospholipids serum_phospholipids 0.0419 3.97E-06 no no up no up up 20:2-LPC+blood 20:5/18:0-PC+blood 0 0 0.515213675 serum_phospholipids serum_phospholipids 0.119 3.97E-06 no no up no up up 20:2/18:1-PE+blood 20:5/18:0-PC+blood 0 -0.522058824 0 serum_phospholipids serum_phospholipids 0.00208 3.97E-06 up up no no up up 20:2+blood 20:5/18:0-PC+blood 0 0 0.422222222 serum_fattyacid serum_phospholipids 0.478 3.97E-06 no no no no up up 20:3-LPE+blood 20:5/18:0-PC+blood -0.536842105 0 0 serum_phospholipids serum_phospholipids 0.084 3.97E-06 no up no no up up 20:3/16:0-PC+blood 20:5/18:0-PC+blood 0 0.762254902 0 serum_phospholipids serum_phospholipids 0.00405 3.97E-06 no up up no up up 20:3/18:0-PC+blood 20:5/18:0-PC+blood 0.532330827 0.806372549 0.575384615 serum_phospholipids serum_phospholipids 0.296 3.97E-06 no no no no up up 20:4-LPE+blood 20:5/18:0-PC+blood 0 0.566176471 0 serum_phospholipids serum_phospholipids 0.552 3.97E-06 no no no no up up 20:4/16:0-PE+blood 20:5/18:0-PC+blood 0 -0.509803922 0 serum_phospholipids serum_phospholipids 0.00529 3.97E-06 no up up no up up 20:4n6+blood 20:5/18:0-PC+blood 0 0.556372549 0 serum_fattyacid serum_phospholipids 0.133 3.97E-06 no no no no up up ACA+stool 20:5/18:0-PC+blood 0 0 0.453174211 stool_bileacids serum_phospholipids 0.417 3.97E-06 no no no no up up AGE-RAGE signaling pathway in diabetic complications 20:5/18:0-PC+blood 0.531578947 0 0 kegg serum_phospholipids NA 3.97E-06 no no no no up up Alzheimer disease 20:5/18:0-PC+blood 0 0 -0.506923077 kegg serum_phospholipids NA 3.97E-06 no no no no up up Amyotrophic lateral sclerosis 20:5/18:0-PC+blood 0 0 -0.446923077 kegg serum_phospholipids NA 3.97E-06 no no no no up up Blautia 20:5/18:0-PC+blood 0 0 -0.492970311 acetate-producing Genus serum_phospholipids 1.36E-05 3.97E-06 up dn dn no up up Butyricimonas 20:5/18:0-PC+blood 0.562948663 0 0.415797998 butyrate-producing Genus serum_phospholipids 0.17 3.97E-06 no no no no up up Cardiac muscle contraction 20:5/18:0-PC+blood 0 0 -0.507692308 kegg serum_phospholipids NA 3.97E-06 no no up no up up CDCA+stool 20:5/18:0-PC+blood 0 0 -0.470676692 stool_bileacids serum_phospholipids 0.663 3.97E-06 no no no no up up Choline metabolism in cancer 20:5/18:0-PC+blood 0 0 -0.47 kegg serum_phospholipids NA 3.97E-06 no no no no up up Cholinergic synapse 20:5/18:0-PC+blood 0 0 -0.489230769 kegg serum_phospholipids NA 3.97E-06 no no no no up up Clostridium 20:5/18:0-PC+blood 0.503196726 0 0 Genus serum_phospholipids 0.925 3.97E-06 no no no no up up Colorectal cancer 20:5/18:0-PC+blood 0 0 -0.484615385 kegg serum_phospholipids NA 3.97E-06 no no no no up up L-Phenylalanine+stool 20:5/18:0-PC+blood 0 0 0.502255639 stool_cometabolism serum_phospholipids 0.398 3.97E-06 no no no no up up L-Tyrosine+stool 20:5/18:0-PC+blood 0 0 0.490225564 stool_cometabolism serum_phospholipids 0.44 3.97E-06 no no no no up up Long-term potentiation 20:5/18:0-PC+blood 0 0 -0.407692308 kegg serum_phospholipids NA 3.97E-06 no no up no up up Necroptosis 20:5/18:0-PC+blood 0 0 0.414615385 kegg serum_phospholipids NA 3.97E-06 no no no no up up Parabacteroides 20:5/18:0-PC+blood 0 0.487745098 0 Genus serum_phospholipids 4.19E-05 3.97E-06 no up up no up up Peroxisome 20:5/18:0-PC+blood 0 0 0.463846154 kegg serum_phospholipids NA 3.97E-06 no no no no up up Prion disease 20:5/18:0-PC+blood 0 0 -0.44 kegg serum_phospholipids NA 3.97E-06 no no no no up up Retrograde endocannabinoid signaling 20:5/18:0-PC+blood 0 0 -0.514615385 kegg serum_phospholipids NA 3.97E-06 no no up no up up Ruminococcus 20:5/18:0-PC+blood 0 0 -0.430775904 Genus serum_phospholipids 0.0679 3.97E-06 no no dn no up up UDCA+stool 20:5/18:0-PC+blood 0 0 -0.527819549 stool_bileacids serum_phospholipids 0.266 3.97E-06 no no no no up up "12,13-EPOME+blood" 20:5n3+blood 0 0 0.435114704 serum_ARA serum_fattyacid 0.901 0.988 no no no no no no 14:0/20:4-PC+blood 20:5n3+blood 0.511278195 0 0 serum_phospholipids serum_fattyacid 0.486 0.988 no no no no no no 16:0/16:0-PI+blood 20:5n3+blood 0 -0.492647059 0 serum_phospholipids serum_fattyacid 0.358 0.988 no no no no no no 16:0/18:0-PC+blood 20:5n3+blood 0 0.509803922 0 serum_phospholipids serum_fattyacid 0.521 0.988 no no no no no no 16:0/18:0-PS+blood 20:5n3+blood 0 0.534313725 0 serum_phospholipids serum_fattyacid 0.377 0.988 no no no no no no 16:0/20:3-PC+blood 20:5n3+blood 0 0 -0.588376068 serum_phospholipids serum_fattyacid 5.43E-06 0.988 no up up no no no 16:0/20:5-PC+blood 20:5n3+blood 0.971428571 0.953431373 0.868034188 serum_phospholipids serum_fattyacid 0.628 0.988 no no no no no no 16:0/22:0-PE+blood 20:5n3+blood 0 0.666666667 0 serum_phospholipids serum_fattyacid 0.00839 0.988 dn no up no no no 16:0/22:6-PC+blood 20:5n3+blood 0 0.639705882 0 serum_phospholipids serum_fattyacid 4.53E-05 0.988 no up up no no no 16:1/18:2-PG+blood 20:5n3+blood -0.452631579 0 0 serum_phospholipids serum_fattyacid 1.40E-08 0.988 no up up no no no 18:0/18:0-PS+blood 20:5n3+blood 0 0.580882353 0 serum_phospholipids serum_fattyacid 0.00617 0.988 no up no no no no 18:0/18:2-PI+blood 20:5n3+blood -0.49924812 0 0 serum_phospholipids serum_fattyacid 0.179 0.988 no no no no no no 18:0/20:3-PC+blood 20:5n3+blood 0 0 -0.446153846 serum_phospholipids serum_fattyacid 0.0682 0.988 no up no no no no 18:0/20:3-PI+blood 20:5n3+blood -0.580451128 0 0 serum_phospholipids serum_fattyacid 0.377 0.988 no no no no no no 18:0/20:4-PC+blood 20:5n3+blood 0 0.568627451 0 serum_phospholipids serum_fattyacid 0.454 0.988 no no no no no no 18:0/20:4-PI+blood 20:5n3+blood -0.44962406 0 0 serum_phospholipids serum_fattyacid 0.167 0.988 no no no no no no 18:0/20:5-PC+blood 20:5n3+blood 0 0.517156863 0 serum_phospholipids serum_fattyacid 0.17 0.988 no no no no no no 18:0/22:6-PA+blood 20:5n3+blood 0 0.507352941 0 serum_phospholipids serum_fattyacid 0.22 0.988 no no no no no no 18:0/22:6-PC+blood 20:5n3+blood 0 0.62254902 0.444102564 serum_phospholipids serum_fattyacid 0.0775 0.988 no no up no no no 18:0/22:6-PE+blood 20:5n3+blood 0 0.578431373 0 serum_phospholipids serum_fattyacid 0.00022 0.988 up up no no no no 18:0/22:6-PI+blood 20:5n3+blood 0 0.507352941 0 serum_phospholipids serum_fattyacid 0.425 0.988 no no no no no no 18:1-LPC+blood 20:5n3+blood -0.652631579 0 0 serum_phospholipids serum_fattyacid 0.179 0.988 no no no no no no 18:1-LPE+blood 20:5n3+blood 0 -0.5 0 serum_phospholipids serum_fattyacid 0.117 0.988 no no no no no no 18:1/16:0-PI+blood 20:5n3+blood 0 -0.509803922 0 serum_phospholipids serum_fattyacid 0.793 0.988 no no no no no no 18:1/18:0-PI+blood 20:5n3+blood -0.488721805 0 0 serum_phospholipids serum_fattyacid 0.0931 0.988 no no up no no no 18:1/18:0-PS+blood 20:5n3+blood 0 0.575980392 0 serum_phospholipids serum_fattyacid 0.193 0.988 no no no no no no 18:1/18:1-PC+blood 20:5n3+blood 0 0 -0.615042735 serum_phospholipids serum_fattyacid 1.34E-05 0.988 no up up no no no 18:1/18:2-PI+blood 20:5n3+blood -0.565413534 0 0 serum_phospholipids serum_fattyacid 0.0164 0.988 dn no up no no no 18:1/20:3-PC+blood 20:5n3+blood 0 0 -0.628034188 serum_phospholipids serum_fattyacid 0.00872 0.988 no up up no no no 18:2-LPA+blood 20:5n3+blood 0 -0.634803922 0 serum_phospholipids serum_fattyacid 0.00684 0.988 dn no up no no no 18:2-LPC+blood 20:5n3+blood -0.463157895 0 0 serum_phospholipids serum_fattyacid 0.00743 0.988 dn no up no no no 18:2-LPE+blood 20:5n3+blood 0 -0.551470588 0 serum_phospholipids serum_fattyacid 0.112 0.988 no no no no no no 20:0/20:4-PE+blood 20:5n3+blood 0 0 -0.497435897 serum_phospholipids serum_fattyacid 0.00128 0.988 up up no no no no 20:2-LPC+blood 20:5n3+blood -0.672180451 0 0 serum_phospholipids serum_fattyacid 0.119 0.988 no no up no no no 20:2/18:0-PC+blood 20:5n3+blood 0 0 -0.417435897 serum_phospholipids serum_fattyacid 0.0427 0.988 no up no no no no 20:2+blood 20:5n3+blood -0.618045113 0 -0.420854701 serum_fattyacid serum_fattyacid 0.478 0.988 no no no no no no 20:3-LPE+blood 20:5n3+blood 0 -0.575980392 -0.415384615 serum_phospholipids serum_fattyacid 0.084 0.988 no up no no no no 20:4-LPE+blood 20:5n3+blood 0 0 -0.511794872 serum_phospholipids serum_fattyacid 0.552 0.988 no no no no no no 20:4n6+blood 20:5n3+blood 0 0.62254902 0 serum_fattyacid serum_fattyacid 0.133 0.988 no no no no no no 20:5-LPC+blood 20:5n3+blood 0.968421053 0.732843137 0.870769231 serum_phospholipids serum_fattyacid 0.558 0.988 no no no no no no 20:5/18:0-PC+blood 20:5n3+blood 0 0.539215686 0 serum_phospholipids serum_fattyacid 3.97E-06 0.988 no up up no no no 4-hydroxybenzoic acid+stool 20:5n3+blood -0.593406593 0 0 stool_cometabolism serum_fattyacid 0.0536 0.988 no dn no no no no Amoebiasis 20:5n3+blood 0 -0.538235294 0 kegg serum_fattyacid NA 0.988 no no no no no no Bacteroides 20:5n3+blood 0 0.578431373 0 LPS-producing Genus serum_fattyacid 0.000267 0.988 dn dn up no no no Butyricimonas 20:5n3+blood 0 0.546030095 0 butyrate-producing Genus serum_fattyacid 0.17 0.988 no no no no no no cAMP signaling pathway 20:5n3+blood 0 -0.611764706 0 yes kegg serum_fattyacid NA 0.988 no up up no no no Cholinergic synapse 20:5n3+blood 0 0.555882353 0 kegg serum_fattyacid NA 0.988 no no no no no no Coprococcus 20:5n3+blood 0.517293233 0 0 butyrate-producing Genus serum_fattyacid 0.612 0.988 no no no no no no Ferroptosis 20:5n3+blood 0 -0.652941176 0 kegg serum_fattyacid NA 0.988 no no no no no no Kaposi sarcoma-associated herpesvirus infection 20:5n3+blood 0 -0.688235294 0 kegg serum_fattyacid NA 0.988 no no dn no no no Long-term depression 20:5n3+blood 0 -0.505882353 0 kegg serum_fattyacid NA 0.988 no no no no no no Malaria 20:5n3+blood 0 -0.570588235 0 kegg serum_fattyacid NA 0.988 no no no no no no MAPK signaling pathway 20:5n3+blood 0 0.605882353 0 kegg serum_fattyacid NA 0.988 no no no no no no Necroptosis 20:5n3+blood 0 -0.555882353 0 kegg serum_fattyacid NA 0.988 no no no no no no Oscillospira 20:5n3+blood 0.482706767 0 0 LPS-producing Genus serum_fattyacid 0.62 0.988 no no no no no no Phosphatidylinositol signaling system 20:5n3+blood 0 0.552941176 0 kegg serum_fattyacid NA 0.988 no no no no no no Primary immunodeficiency 20:5n3+blood 0 0.547058824 0 kegg serum_fattyacid NA 0.988 no no no no no no Progesterone-mediated oocyte maturation 20:5n3+blood 0 0.561764706 0 kegg serum_fattyacid NA 0.988 no no no no no no Ras signaling pathway 20:5n3+blood -0.466666667 0 0 yes kegg serum_fattyacid NA 0.988 no up up no no no Renal cell carcinoma 20:5n3+blood -0.471929825 0 0 kegg serum_fattyacid NA 0.988 no no no no no no Ribosome biogenesis in eukaryotes 20:5n3+blood 0 0.514705882 0 kegg serum_fattyacid NA 0.988 no no no no no no Shigellosis 20:5n3+blood 0 -0.576470588 0 kegg serum_fattyacid NA 0.988 no no no no no no Viral protein interaction with cytokine and cytokine receptor 20:5n3+blood 0 -0.573529412 0 kegg serum_fattyacid NA 0.988 no no no no no no 14:0-LPC+blood 22:0/16:0-PE+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.00689 0.091 up up no no no up 14:1/18:2-PG+blood 22:0/16:0-PE+blood 0 0 -0.426324786 serum_phospholipids serum_phospholipids 0.00259 0.091 no up up no no up 16:0-LPE+blood 22:0/16:0-PE+blood 0 -0.482843137 0 serum_phospholipids serum_phospholipids 0.0711 0.091 up up no no no up 16:0/14:0-PC+blood 22:0/16:0-PE+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 0.0206 0.091 no up up no no up 16:0/16:0-PC+blood 22:0/16:0-PE+blood 0.452631579 0.62745098 0 serum_phospholipids serum_phospholipids 0.00079 0.091 no up up no no up 16:0/16:0-PI+blood 22:0/16:0-PE+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.358 0.091 no no no no no up 16:0/18:0-PC+blood 22:0/16:0-PE+blood 0 0 0.589059829 serum_phospholipids serum_phospholipids 0.521 0.091 no no no no no up 16:0/18:1-PC+blood 22:0/16:0-PE+blood 0 0.830882353 0 serum_phospholipids serum_phospholipids 6.15E-07 0.091 up up up no no up 16:0/18:2-PC+blood 22:0/16:0-PE+blood 0 0.649509804 0 serum_phospholipids serum_phospholipids 3.24E-06 0.091 no up up no no up 16:0/20:4-PC+blood 22:0/16:0-PE+blood 0 0.566176471 0 serum_phospholipids serum_phospholipids 0.0262 0.091 no up no no no up 16:0/20:5-PC+blood 22:0/16:0-PE+blood 0.512781955 0.509803922 0 serum_phospholipids serum_phospholipids 0.628 0.091 no no no no no up 16:0/22:0-PE+blood 22:0/16:0-PE+blood 0.845112782 0.816176471 0.667692308 serum_phospholipids serum_phospholipids 0.00839 0.091 dn no up no no up 16:0/22:6-PC+blood 22:0/16:0-PE+blood 0.82406015 0.75245098 0.646495726 serum_phospholipids serum_phospholipids 4.53E-05 0.091 no up up no no up 16:1/16:0-PC+blood 22:0/16:0-PE+blood 0 0.703431373 0 serum_phospholipids serum_phospholipids 0.0215 0.091 no up up no no up 18:0-LPC+blood 22:0/16:0-PE+blood 0 -0.588235294 0 serum_phospholipids serum_phospholipids 0.554 0.091 no no no no no up 18:0-LPE+blood 22:0/16:0-PE+blood 0 -0.634803922 0 serum_phospholipids serum_phospholipids 0.491 0.091 no no no no no up 18:0/16:0-PC+blood 22:0/16:0-PE+blood 0 0.786764706 0 serum_phospholipids serum_phospholipids 9.64E-07 0.091 up up up no no up 18:0/18:0-PC+blood 22:0/16:0-PE+blood 0 0 0.543931624 serum_phospholipids serum_phospholipids 0.426 0.091 no no no no no up 18:0/18:1-PC+blood 22:0/16:0-PE+blood 0 0 0.499487179 serum_phospholipids serum_phospholipids 0.393 0.091 no no no no no up 18:0/18:1-PG+blood 22:0/16:0-PE+blood 0 -0.514705882 -0.515897436 serum_phospholipids serum_phospholipids 0.000842 0.091 no up no no no up 18:0/18:2-PC+blood 22:0/16:0-PE+blood 0 0.700980392 0.549401709 serum_phospholipids serum_phospholipids 1.74E-06 0.091 no up up no no up 18:0/18:2-PI+blood 22:0/16:0-PE+blood 0 0 -0.464615385 serum_phospholipids serum_phospholipids 0.179 0.091 no no no no no up 18:0/20:2-PC+blood 22:0/16:0-PE+blood 0 0 0.424273504 serum_phospholipids serum_phospholipids 0.733 0.091 no no no no no up 18:0/20:4-PC+blood 22:0/16:0-PE+blood 0 0.656862745 0 serum_phospholipids serum_phospholipids 0.454 0.091 no no no no no up 18:0/20:5-PC+blood 22:0/16:0-PE+blood 0.554887218 0.5 0 serum_phospholipids serum_phospholipids 0.17 0.091 no no no no no up 18:0/22:6-PA+blood 22:0/16:0-PE+blood 0 0.575980392 0 serum_phospholipids serum_phospholipids 0.22 0.091 no no no no no up 18:0/22:6-PC+blood 22:0/16:0-PE+blood 0.742857143 0.583333333 0 serum_phospholipids serum_phospholipids 0.0775 0.091 no no up no no up 18:0/22:6-PI+blood 22:0/16:0-PE+blood 0.502255639 0 0 serum_phospholipids serum_phospholipids 0.425 0.091 no no no no no up 18:1-LPE+blood 22:0/16:0-PE+blood -0.523308271 0 0 serum_phospholipids serum_phospholipids 0.117 0.091 no no no no no up 18:1/16:0-PC+blood 22:0/16:0-PE+blood 0 0.649509804 0 serum_phospholipids serum_phospholipids 2.43E-05 0.091 no up up no no up 18:1/18:0-PC+blood 22:0/16:0-PE+blood 0 0.693627451 0.548717949 serum_phospholipids serum_phospholipids 1.83E-06 0.091 no up up no no up 18:1/18:0-PI+blood 22:0/16:0-PE+blood 0 0 -0.438632479 serum_phospholipids serum_phospholipids 0.0931 0.091 no no up no no up 18:1/22:6-PE+blood 22:0/16:0-PE+blood 0 0 0.496068376 serum_phospholipids serum_phospholipids 0.0047 0.091 no up no no no up 18:2/16:0-PC+blood 22:0/16:0-PE+blood 0 0.585784314 0 serum_phospholipids serum_phospholipids 8.67E-05 0.091 no up up no no up 18:2/20:4-PC+blood 22:0/16:0-PE+blood 0.481203008 0 0 serum_phospholipids serum_phospholipids 0.0145 0.091 no no up no no up 18:3/16:0-PE+blood 22:0/16:0-PE+blood 0 -0.593137255 0 serum_phospholipids serum_phospholipids 0.00149 0.091 up up no no no up 18:3n6+blood 22:0/16:0-PE+blood 0 -0.495098039 0 serum_fattyacid serum_phospholipids 0.0463 0.091 up no dn no no up 20:0/20:4-PE+blood 22:0/16:0-PE+blood 0 -0.595588235 0 serum_phospholipids serum_phospholipids 0.00128 0.091 up up no no no up 20:1-LPC+blood 22:0/16:0-PE+blood 0 0 0.511794872 serum_phospholipids serum_phospholipids 0.217 0.091 no no no no no up 20:1/20:4-PC+blood 22:0/16:0-PE+blood 0.681203008 0.671568627 0.428376068 serum_phospholipids serum_phospholipids 0.0419 0.091 no no up no no up 20:1/20:4-PE+blood 22:0/16:0-PE+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.0042 0.091 up up no no no up 20:2-LPC+blood 22:0/16:0-PE+blood 0 0 0.440683761 serum_phospholipids serum_phospholipids 0.119 0.091 no no up no no up 20:2/18:1-PE+blood 22:0/16:0-PE+blood 0 -0.50245098 0 serum_phospholipids serum_phospholipids 0.00208 0.091 up up no no no up 20:3-LPE+blood 22:0/16:0-PE+blood -0.690225564 0 0 serum_phospholipids serum_phospholipids 0.084 0.091 no up no no no up 20:3/16:0-PC+blood 22:0/16:0-PE+blood 0 0.639705882 0 serum_phospholipids serum_phospholipids 0.00405 0.091 no up up no no up 20:3/18:0-PC+blood 22:0/16:0-PE+blood 0.481203008 0.62254902 0.680683761 serum_phospholipids serum_phospholipids 0.296 0.091 no no no no no up 20:3/18:0-PI+blood 22:0/16:0-PE+blood 0 0 -0.436581197 serum_phospholipids serum_phospholipids 0.289 0.091 no no no no no up 20:4n6+blood 22:0/16:0-PE+blood 0 0.549019608 0 serum_fattyacid serum_phospholipids 0.133 0.091 no no no no no up 20:5-LPC+blood 22:0/16:0-PE+blood 0.466165414 0 0 serum_phospholipids serum_phospholipids 0.558 0.091 no no no no no up 20:5/18:0-PC+blood 22:0/16:0-PE+blood 0.726315789 0.794117647 0.684786325 serum_phospholipids serum_phospholipids 3.97E-06 0.091 no up up no no up 20:5n3+blood 22:0/16:0-PE+blood 0.512781955 0.531862745 0 serum_fattyacid serum_phospholipids 0.988 0.091 no no no no no up 14:1/18:2-PG+blood 22:1-LPA+blood 0.473684211 0 0 serum_phospholipids serum_phospholipids 0.00259 0.00373 no up up no up up 16:0/22:6-PE+blood 22:1-LPA+blood 0 -0.629901961 0 serum_phospholipids serum_phospholipids 0.000934 0.00373 up up no no up up 16:1/16:1-PC+blood 22:1-LPA+blood 0 0 -0.414700855 serum_phospholipids serum_phospholipids 0.0177 0.00373 no no up no up up 18:0-LPA+blood 22:1-LPA+blood 0 0.715686275 0.431111111 serum_phospholipids serum_phospholipids 0.0725 0.00373 no dn no no up up 18:0/22:6-PC+blood 22:1-LPA+blood 0.493233083 0 0 serum_phospholipids serum_phospholipids 0.0775 0.00373 no no up no up up 18:1-LPE+blood 22:1-LPA+blood -0.488721805 -0.492647059 0.527521368 serum_phospholipids serum_phospholipids 0.117 0.00373 no no no no up up 18:1/18:1-PI+blood 22:1-LPA+blood -0.596992481 0 0 serum_phospholipids serum_phospholipids 0.111 0.00373 dn no no no up up 18:1/20:4-PE+blood 22:1-LPA+blood 0 -0.490196078 0 serum_phospholipids serum_phospholipids 0.0578 0.00373 up no no no up up 18:2-LPA+blood 22:1-LPA+blood 0 0.485294118 0.469401709 serum_phospholipids serum_phospholipids 0.00684 0.00373 dn no up no up up 20:1-LPA+blood 22:1-LPA+blood 0.494736842 0.818627451 0.570598291 serum_phospholipids serum_phospholipids 0.0187 0.00373 dn dn no no up up 20:1-LPC+blood 22:1-LPA+blood -0.603007519 0 0 serum_phospholipids serum_phospholipids 0.217 0.00373 no no no no up up 20:1/20:4-PC+blood 22:1-LPA+blood 0.494736842 0 0 serum_phospholipids serum_phospholipids 0.0419 0.00373 no no up no up up 20:2/18:3-PE+blood 22:1-LPA+blood 0 -0.56127451 0 serum_phospholipids serum_phospholipids 0.0391 0.00373 up up no no up up 20:4-LPA+blood 22:1-LPA+blood 0 0.825980392 0.564444444 serum_phospholipids serum_phospholipids 0.398 0.00373 no no no no up up 20:4/18:0-PE+blood 22:1-LPA+blood 0 -0.522058824 0 serum_phospholipids serum_phospholipids 0.000755 0.00373 up up no no up up 16:0-LPE+blood 22:2-LPA+blood -0.557894737 0 0 serum_phospholipids serum_phospholipids 0.0711 0.0443 up up no dn no no 16:0/18:3-PC+blood 22:2-LPA+blood 0.497744361 0 0 serum_phospholipids serum_phospholipids 0.00216 0.0443 no up up dn no no 16:0/20:5-PC+blood 22:2-LPA+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.628 0.0443 no no no dn no no 16:1/18:1-PG+blood 22:2-LPA+blood 0 0.551470588 0 serum_phospholipids serum_phospholipids 3.21E-05 0.0443 no up up dn no no 18:0-LPA+blood 22:2-LPA+blood 0 0.647058824 0.416752137 serum_phospholipids serum_phospholipids 0.0725 0.0443 no dn no dn no no 18:0-LPE+blood 22:2-LPA+blood -0.467669173 0 0 serum_phospholipids serum_phospholipids 0.491 0.0443 no no no dn no no 18:0/18:2-PI+blood 22:2-LPA+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.179 0.0443 no no no dn no no 18:1-LPE+blood 22:2-LPA+blood 0 0 0.540512821 serum_phospholipids serum_phospholipids 0.117 0.0443 no no no dn no no 18:1/16:0-PI+blood 22:2-LPA+blood 0 0.509803922 0 serum_phospholipids serum_phospholipids 0.793 0.0443 no no no dn no no 18:2-LPA+blood 22:2-LPA+blood 0 0.585784314 0.541880342 serum_phospholipids serum_phospholipids 0.00684 0.0443 dn no up dn no no 2-methyl-butyric acid m-C4+blood 22:2-LPA+blood -0.473684211 0 0 serum_scfa serum_phospholipids 0.262 0.0443 no no no dn no no 20:1-LPA+blood 22:2-LPA+blood 0.634586466 0.715686275 0.610940171 serum_phospholipids serum_phospholipids 0.0187 0.0443 dn dn no dn no no 20:3-LPE+blood 22:2-LPA+blood 0 0 0.408547009 serum_phospholipids serum_phospholipids 0.084 0.0443 no up no dn no no 20:4-LPA+blood 22:2-LPA+blood 0 0 0.44957265 serum_phospholipids serum_phospholipids 0.398 0.0443 no no no dn no no 20:4-LPC+blood 22:2-LPA+blood 0 -0.553921569 0 serum_phospholipids serum_phospholipids 0.949 0.0443 no no no dn no no 20:4n6+blood 22:2-LPA+blood 0 -0.544117647 0 serum_fattyacid serum_phospholipids 0.133 0.0443 no no no dn no no 20:5-LPC+blood 22:2-LPA+blood 0 -0.661764706 0 serum_phospholipids serum_phospholipids 0.558 0.0443 no no no dn no no 20:5n3+blood 22:2-LPA+blood 0 -0.578431373 -0.422222222 serum_fattyacid serum_phospholipids 0.988 0.0443 no no no dn no no 22:1-LPA+blood 22:2-LPA+blood 0 0.649509804 0.60957265 serum_phospholipids serum_phospholipids 0.00373 0.0443 no up up dn no no 14:0-LPC+blood 22:6-LPC+blood 0 -0.512254902 0 serum_phospholipids serum_phospholipids 0.00689 0.127 up up no no no up 14:0/18:0-PC+blood 22:6-LPC+blood 0 -0.620098039 0 serum_phospholipids serum_phospholipids 0.00289 0.127 up up no no no up 14:0+blood 22:6-LPC+blood 0.658646617 0 0 yes serum_fattyacid serum_phospholipids 0.00572 0.127 up no dn no no up 16:0-LPC+blood 22:6-LPC+blood 0.490225564 0 0 serum_phospholipids serum_phospholipids 0.00456 0.127 up up no no no up 16:0/14:0-PC+blood 22:6-LPC+blood -0.445112782 0 0 serum_phospholipids serum_phospholipids 0.0206 0.127 no up up no no up 16:0/16:0-PI+blood 22:6-LPC+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.358 0.127 no no no no no up 16:0/16:1-PC+blood 22:6-LPC+blood -0.44962406 -0.590686275 0 serum_phospholipids serum_phospholipids 0.00283 0.127 up up no no no up 16:0/16:1-PI+blood 22:6-LPC+blood 0 -0.558823529 0 serum_phospholipids serum_phospholipids 0.262 0.127 no no no no no up 16:0/18:2-PI+blood 22:6-LPC+blood 0 -0.588235294 0 serum_phospholipids serum_phospholipids 0.269 0.127 no no no no no up 16:0/20:4-PC+blood 22:6-LPC+blood 0 0.529411765 0 serum_phospholipids serum_phospholipids 0.0262 0.127 no up no no no up 16:0/20:5-PC+blood 22:6-LPC+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 0.628 0.127 no no no no no up 16:0/22:6-PC+blood 22:6-LPC+blood 0 0.823529412 0.516581197 serum_phospholipids serum_phospholipids 4.53E-05 0.127 no up up no no up 16:1/16:0-PC+blood 22:6-LPC+blood 0 0.620098039 0 serum_phospholipids serum_phospholipids 0.0215 0.127 no up up no no up 16:1+blood 22:6-LPC+blood 0.464661654 0 0 yes serum_fattyacid serum_phospholipids 0.0186 0.127 no no dn no no up 18:0/20:4-PC+blood 22:6-LPC+blood 0 0.703431373 0 serum_phospholipids serum_phospholipids 0.454 0.127 no no no no no up 18:0/20:5-PC+blood 22:6-LPC+blood 0 0.764705882 0 serum_phospholipids serum_phospholipids 0.17 0.127 no no no no no up 18:0/22:6-PC+blood 22:6-LPC+blood 0.598496241 0.767156863 0.606153846 serum_phospholipids serum_phospholipids 0.0775 0.127 no no up no no up 18:0/22:6-PI+blood 22:6-LPC+blood 0.636090226 0.529411765 0.548034188 serum_phospholipids serum_phospholipids 0.425 0.127 no no no no no up 18:1/16:0-PI+blood 22:6-LPC+blood 0 -0.573529412 0 serum_phospholipids serum_phospholipids 0.793 0.127 no no no no no up 18:1/18:0-PE+blood 22:6-LPC+blood 0 -0.556372549 0 serum_phospholipids serum_phospholipids 1.39E-06 0.127 up up no no no up 18:1/18:0-PI+blood 22:6-LPC+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.0931 0.127 no no up no no up 18:1/18:1-PC+blood 22:6-LPC+blood 0 -0.524509804 0 serum_phospholipids serum_phospholipids 1.34E-05 0.127 no up up no no up 18:1/18:2-PE+blood 22:6-LPC+blood 0 -0.585784314 0 serum_phospholipids serum_phospholipids 0.000293 0.127 up up no no no up 18:1/20:3-PC+blood 22:6-LPC+blood 0 -0.588235294 0 serum_phospholipids serum_phospholipids 0.00872 0.127 no up up no no up 18:1/20:4-PC+blood 22:6-LPC+blood 0 0.666666667 0 serum_phospholipids serum_phospholipids 0.582 0.127 no no no no no up 18:2/18:2-PS+blood 22:6-LPC+blood 0 -0.578431373 0 serum_phospholipids serum_phospholipids 0.00674 0.127 up up no no no up 18:3n3+blood 22:6-LPC+blood 0 0.522058824 0 serum_fattyacid serum_phospholipids 0.291 0.127 no no no no no up 20:0/20:4-PE+blood 22:6-LPC+blood -0.497744361 -0.691176471 -0.558290598 serum_phospholipids serum_phospholipids 0.00128 0.127 up up no no no up 20:0/20:5-PC+blood 22:6-LPC+blood 0 0.522058824 0 serum_phospholipids serum_phospholipids 0.882 0.127 no no no no no up 20:1/20:4-PC+blood 22:6-LPC+blood 0.539849624 0.598039216 0.555555556 serum_phospholipids serum_phospholipids 0.0419 0.127 no no up no no up 20:1/20:4-PE+blood 22:6-LPC+blood 0 0 -0.483760684 serum_phospholipids serum_phospholipids 0.0042 0.127 up up no no no up 20:2/18:1-PE+blood 22:6-LPC+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.00208 0.127 up up no no no up 20:2/18:3-PE+blood 22:6-LPC+blood 0 0 -0.437948718 serum_phospholipids serum_phospholipids 0.0391 0.127 up up no no no up 20:2+blood 22:6-LPC+blood 0 -0.573529412 0 serum_fattyacid serum_phospholipids 0.478 0.127 no no no no no up 20:3-LPC+blood 22:6-LPC+blood 0 -0.512254902 0 serum_phospholipids serum_phospholipids 0.0292 0.127 no up no no no up 20:3-LPE+blood 22:6-LPC+blood 0 -0.590686275 -0.427008547 serum_phospholipids serum_phospholipids 0.084 0.127 no up no no no up 20:3/16:0-PC+blood 22:6-LPC+blood 0 0.526960784 0 serum_phospholipids serum_phospholipids 0.00405 0.127 no up up no no up 20:3n6+blood 22:6-LPC+blood 0 -0.68872549 0 serum_fattyacid serum_phospholipids 0.0884 0.127 up no no no no up 20:4-LPC+blood 22:6-LPC+blood 0 0.678921569 0 serum_phospholipids serum_phospholipids 0.949 0.127 no no no no no up 20:4-LPE+blood 22:6-LPC+blood 0 0 -0.40034188 serum_phospholipids serum_phospholipids 0.552 0.127 no no no no no up 20:4/18:0-PE+blood 22:6-LPC+blood 0 0 -0.422905983 serum_phospholipids serum_phospholipids 0.000755 0.127 up up no no no up 20:5-LPC+blood 22:6-LPC+blood 0 0.649509804 0.734700855 serum_phospholipids serum_phospholipids 0.558 0.127 no no no no no up 20:5/18:0-PC+blood 22:6-LPC+blood 0 0.74754902 0.481709402 serum_phospholipids serum_phospholipids 3.97E-06 0.127 no up up no no up 20:5n3+blood 22:6-LPC+blood 0 0.519607843 0.524102564 serum_fattyacid serum_phospholipids 0.988 0.127 no no no no no up 22:2-LPA+blood 22:6-LPC+blood -0.464661654 0 0 serum_phospholipids serum_phospholipids 0.0443 0.127 dn no no no no up 14:0/18:2-PC+blood 22:6n3+blood 0.530827068 0 0 serum_phospholipids serum_fattyacid 0.102 0.792 no up no no no no 14:0/20:4-PC+blood 22:6n3+blood 0.466165414 0 0 serum_phospholipids serum_fattyacid 0.486 0.792 no no no no no no 14:0+blood 22:6n3+blood 0.603007519 0 0 yes serum_fattyacid serum_fattyacid 0.00572 0.792 up no dn no no no 16:0/16:0-PI+blood 22:6n3+blood 0.458646617 -0.529411765 0 serum_phospholipids serum_fattyacid 0.358 0.792 no no no no no no 16:0/18:0-PS+blood 22:6n3+blood 0 0.669117647 0 serum_phospholipids serum_fattyacid 0.377 0.792 no no no no no no 16:0/20:4-PC+blood 22:6n3+blood -0.485714286 0 0 serum_phospholipids serum_fattyacid 0.0262 0.792 no up no no no no 16:0/20:4-PI+blood 22:6n3+blood 0.484210526 0 0 serum_phospholipids serum_fattyacid 0.558 0.792 no no no no no no 16:0/20:5-PC+blood 22:6n3+blood 0.479699248 0.651960784 0 serum_phospholipids serum_fattyacid 0.628 0.792 no no no no no no 16:0/20:5-PG+blood 22:6n3+blood -0.467669173 0 0 serum_phospholipids serum_fattyacid 0.00656 0.792 no up no no no no 16:0/22:0-PE+blood 22:6n3+blood 0 0.625 0 serum_phospholipids serum_fattyacid 0.00839 0.792 dn no up no no no 16:0/22:6-PC+blood 22:6n3+blood 0.476691729 0.816176471 0.650598291 serum_phospholipids serum_fattyacid 4.53E-05 0.792 no up up no no no 16:0+blood 22:6n3+blood 0.509774436 0 0 yes serum_fattyacid serum_fattyacid 0.00876 0.792 up no no no no no 16:1/16:0-PC+blood 22:6n3+blood 0 0.607843137 0 serum_phospholipids serum_fattyacid 0.0215 0.792 no up up no no no 18:0-LPE+blood 22:6n3+blood 0.467669173 0 0 serum_phospholipids serum_fattyacid 0.491 0.792 no no no no no no 18:0/18:0-PS+blood 22:6n3+blood 0 0.568627451 0 serum_phospholipids serum_fattyacid 0.00617 0.792 no up no no no no 18:0/20:3-PC+blood 22:6n3+blood 0.488721805 0 0 serum_phospholipids serum_fattyacid 0.0682 0.792 no up no no no no 18:0/20:4-PC+blood 22:6n3+blood 0 0.681372549 0 serum_phospholipids serum_fattyacid 0.454 0.792 no no no no no no 18:0/20:4-PI+blood 22:6n3+blood 0 0.617647059 0 serum_phospholipids serum_fattyacid 0.167 0.792 no no no no no no 18:0/20:5-PC+blood 22:6n3+blood 0 0.654411765 0 serum_phospholipids serum_fattyacid 0.17 0.792 no no no no no no 18:0/22:6-PA+blood 22:6n3+blood 0 0.5 0.456410256 serum_phospholipids serum_fattyacid 0.22 0.792 no no no no no no 18:0/22:6-PC+blood 22:6n3+blood 0.657142857 0.845588235 0.648547009 serum_phospholipids serum_fattyacid 0.0775 0.792 no no up no no no 18:0/22:6-PE+blood 22:6n3+blood 0 0.725490196 0 serum_phospholipids serum_fattyacid 0.00022 0.792 up up no no no no 18:0/22:6-PI+blood 22:6n3+blood 0.766917293 0.818627451 0.650598291 serum_phospholipids serum_fattyacid 0.425 0.792 no no no no no no 18:0+blood 22:6n3+blood 0.478195489 0 0 serum_fattyacid serum_fattyacid 0.344 0.792 no no no no no no 18:1-LPC+blood 22:6n3+blood -0.476691729 0 0 serum_phospholipids serum_fattyacid 0.179 0.792 no no no no no no 18:1-LPE+blood 22:6n3+blood 0 -0.536764706 -0.422222222 serum_phospholipids serum_fattyacid 0.117 0.792 no no no no no no 18:1/16:0-PI+blood 22:6n3+blood 0 -0.5 0 serum_phospholipids serum_fattyacid 0.793 0.792 no no no no no no 18:1/18:0-PS+blood 22:6n3+blood 0 0.678921569 0.404444444 serum_phospholipids serum_fattyacid 0.193 0.792 no no no no no no 18:1/18:1-PC+blood 22:6n3+blood -0.472180451 0 0 serum_phospholipids serum_fattyacid 1.34E-05 0.792 no up up no no no 18:1/20:4-PC+blood 22:6n3+blood 0 0.647058824 0 serum_phospholipids serum_fattyacid 0.582 0.792 no no no no no no 18:1/22:6-PE+blood 22:6n3+blood 0 0.769607843 0.478974359 serum_phospholipids serum_fattyacid 0.0047 0.792 no up no no no no 18:2-LPA+blood 22:6n3+blood 0 -0.551470588 0 serum_phospholipids serum_fattyacid 0.00684 0.792 dn no up no no no 18:2-LPE+blood 22:6n3+blood 0 -0.585784314 0 serum_phospholipids serum_fattyacid 0.112 0.792 no no no no no no 18:2/18:1-PC+blood 22:6n3+blood -0.503759398 0 0 serum_phospholipids serum_fattyacid 2.30E-05 0.792 dn up up no no no 18:2/18:2-PC+blood 22:6n3+blood -0.497744361 0 0 serum_phospholipids serum_fattyacid 1.98E-05 0.792 dn up up no no no 20:0/20:4-PE+blood 22:6n3+blood 0 0 -0.506324786 serum_phospholipids serum_fattyacid 0.00128 0.792 up up no no no no 20:0/20:5-PC+blood 22:6n3+blood 0 0.541666667 0 serum_phospholipids serum_fattyacid 0.882 0.792 no no no no no no 20:0+blood 22:6n3+blood -0.571428571 0 0 yes serum_fattyacid serum_fattyacid 0.000278 0.792 dn no up no no no 20:1/20:4-PC+blood 22:6n3+blood 0.529323308 0.691176471 0.579487179 serum_phospholipids serum_fattyacid 0.0419 0.792 no no up no no no 20:1+blood 22:6n3+blood -0.487218045 0 0 yes serum_fattyacid serum_fattyacid 2.56E-05 0.792 dn dn dn no no no 20:2/18:0-PC+blood 22:6n3+blood 0.518796992 0 0 serum_phospholipids serum_fattyacid 0.0427 0.792 no up no no no no 20:3-LPE+blood 22:6n3+blood 0 -0.571078431 -0.474871795 serum_phospholipids serum_fattyacid 0.084 0.792 no up no no no no 20:3/16:0-PC+blood 22:6n3+blood -0.568421053 0 0 serum_phospholipids serum_fattyacid 0.00405 0.792 no up up no no no 20:3/18:0-PI+blood 22:6n3+blood 0 0.551470588 0 serum_phospholipids serum_fattyacid 0.289 0.792 no no no no no no 20:4/16:0-PE+blood 22:6n3+blood 0 -0.544117647 0 serum_phospholipids serum_fattyacid 0.00529 0.792 no up up no no no 20:4n6+blood 22:6n3+blood 0 0.625 0 serum_fattyacid serum_fattyacid 0.133 0.792 no no no no no no 20:5-LPC+blood 22:6n3+blood 0 0.487745098 0.472136752 serum_phospholipids serum_fattyacid 0.558 0.792 no no no no no no 20:5/18:0-PC+blood 22:6n3+blood 0 0.75 0.540512821 serum_phospholipids serum_fattyacid 3.97E-06 0.792 no up up no no no 20:5n3+blood 22:6n3+blood 0.527819549 0.757352941 0.481709402 serum_fattyacid serum_fattyacid 0.988 0.792 no no no no no no 22:0/16:0-PE+blood 22:6n3+blood 0.57593985 0.585784314 0.40991453 serum_phospholipids serum_fattyacid 0.091 0.792 no no up no no no 22:6-LPC+blood 22:6n3+blood 0.646616541 0.710784314 0.752478632 serum_phospholipids serum_fattyacid 0.127 0.792 no no up no no no Adipocytokine signaling pathway 22:6n3+blood -0.463157895 0 0 kegg serum_fattyacid NA 0.792 no no no no no no Alzheimer disease 22:6n3+blood 0 -0.517647059 0 kegg serum_fattyacid NA 0.792 no no no no no no Amyotrophic lateral sclerosis 22:6n3+blood -0.461403509 -0.511764706 0 kegg serum_fattyacid NA 0.792 no no no no no no Bacteroides 22:6n3+blood 0 0 0.475555556 LPS-producing Genus serum_fattyacid 0.000267 0.792 dn dn up no no no Calcium signaling pathway 22:6n3+blood 0 -0.552941176 0 kegg serum_fattyacid NA 0.792 no up up no no no cAMP signaling pathway 22:6n3+blood 0 -0.529411765 0 yes kegg serum_fattyacid NA 0.792 no up up no no no Cardiac muscle contraction 22:6n3+blood 0 -0.526470588 0 kegg serum_fattyacid NA 0.792 no no up no no no Cholinergic synapse 22:6n3+blood 0 0.611764706 0 kegg serum_fattyacid NA 0.792 no no no no no no Cytosolic DNA-sensing pathway 22:6n3+blood -0.592982456 0 0 kegg serum_fattyacid NA 0.792 no no no no no no Diabetic cardiomyopathy 22:6n3+blood 0 -0.505882353 0 kegg serum_fattyacid NA 0.792 no no no no no no Ferroptosis 22:6n3+blood 0 -0.508823529 0 kegg serum_fattyacid NA 0.792 no no no no no no GABAergic synapse 22:6n3+blood 0.48245614 0 0 kegg serum_fattyacid NA 0.792 no up up no no no Hepatitis C 22:6n3+blood 0 -0.517647059 0 kegg serum_fattyacid NA 0.792 no no no no no no Huntington disease 22:6n3+blood 0 -0.544117647 0 kegg serum_fattyacid NA 0.792 no no no no no no Kaposi sarcoma-associated herpesvirus infection 22:6n3+blood 0 -0.764705882 0 kegg serum_fattyacid NA 0.792 no no dn no no no Longevity regulating pathway - multiple species 22:6n3+blood 0.514035088 0 0 kegg serum_fattyacid NA 0.792 no no no no no no Malaria 22:6n3+blood 0 -0.614705882 0 kegg serum_fattyacid NA 0.792 no no no no no no MAPK signaling pathway 22:6n3+blood 0 0.514705882 0 kegg serum_fattyacid NA 0.792 no no no no no no Mineral absorption 22:6n3+blood 0 -0.732352941 0 kegg serum_fattyacid NA 0.792 no no no no no no Mitophagy - animal 22:6n3+blood 0 -0.741176471 0 kegg serum_fattyacid NA 0.792 no no no no no no Necroptosis 22:6n3+blood 0 -0.7 0 kegg serum_fattyacid NA 0.792 no no no no no no Non-alcoholic fatty liver disease 22:6n3+blood 0 -0.602941176 0 kegg serum_fattyacid NA 0.792 no no no no no no Oxidative phosphorylation 22:6n3+blood 0 -0.526470588 0 kegg serum_fattyacid NA 0.792 no no no no no no Parkinson disease 22:6n3+blood 0 -0.602941176 0 kegg serum_fattyacid NA 0.792 no no no no no no Pathways of neurodegeneration - multiple diseases 22:6n3+blood 0 -0.6 0 kegg serum_fattyacid NA 0.792 no no no no no no Phenylacetic acid+stool 22:6n3+blood -0.582417582 0 0 stool_cometabolism serum_fattyacid 0.785 0.792 no no no no no no Ruminococcus 22:6n3+blood 0 0 0.494700855 acetate-producing Genus serum_fattyacid 0.335 0.792 no no no no no no Shigellosis 22:6n3+blood -0.505263158 -0.805882353 0 kegg serum_fattyacid NA 0.792 no no no no no no Th1 and Th2 cell differentiation 22:6n3+blood -0.571929825 0 0 kegg serum_fattyacid NA 0.792 no no no no no no Th17 cell differentiation 22:6n3+blood -0.521052632 0 0 kegg serum_fattyacid NA 0.792 no no no no no no Thermogenesis 22:6n3+blood -0.49122807 0 0 kegg serum_fattyacid NA 0.792 no no no no no no Ubiquitin mediated proteolysis 22:6n3+blood 0 -0.661764706 0 kegg serum_fattyacid NA 0.792 no no no no no no 13-HODE+blood 24:0+blood 0.472180451 0 0 serum_ARA serum_fattyacid 0.32 0.034 no no no dn no up 14:0-LPC+blood 24:0+blood 0 0 0.415384615 serum_phospholipids serum_fattyacid 0.00689 0.034 up up no dn no up 14:0/16:0-PC+blood 24:0+blood 0 0 0.485811966 serum_phospholipids serum_fattyacid 0.0358 0.034 no up no dn no up 14:0/18:2-PC+blood 24:0+blood 0 0.49754902 0.427008547 serum_phospholipids serum_fattyacid 0.102 0.034 no up no dn no up 14:0+blood 24:0+blood 0 0 0.436581197 yes serum_fattyacid serum_fattyacid 0.00572 0.034 up no dn dn no up 16:0/16:0-PI+blood 24:0+blood 0 0 0.460512821 serum_phospholipids serum_fattyacid 0.358 0.034 no no no dn no up 16:0/18:3-PC+blood 24:0+blood 0 0 0.426324786 serum_phospholipids serum_fattyacid 0.00216 0.034 no up up dn no up 16:0/20:3-PC+blood 24:0+blood 0 0.713235294 0 serum_phospholipids serum_fattyacid 5.43E-06 0.034 no up up dn no up 18:0/18:2-PI+blood 24:0+blood 0.485714286 0 0 serum_phospholipids serum_fattyacid 0.179 0.034 no no no dn no up 18:0/20:3-PI+blood 24:0+blood 0 0.539215686 0 serum_phospholipids serum_fattyacid 0.377 0.034 no no no dn no up 18:0+blood 24:0+blood 0 0.546568627 0 serum_fattyacid serum_fattyacid 0.344 0.034 no no no dn no up 18:1/18:0-PS+blood 24:0+blood 0 0.504901961 0 serum_phospholipids serum_fattyacid 0.193 0.034 no no no dn no up 18:1/18:1-PC+blood 24:0+blood 0 0.659313725 0 serum_phospholipids serum_fattyacid 1.34E-05 0.034 no up up dn no up 18:1/20:3-PC+blood 24:0+blood 0 0.620098039 0 serum_phospholipids serum_fattyacid 0.00872 0.034 no up up dn no up 18:3-LPC+blood 24:0+blood 0 -0.590686275 0 serum_phospholipids serum_fattyacid 0.147 0.034 no no no dn no up 18:3n3+blood 24:0+blood 0 -0.549019608 0 serum_fattyacid serum_fattyacid 0.291 0.034 no no no dn no up 18:3n6+blood 24:0+blood 0 0 0.426324786 serum_fattyacid serum_fattyacid 0.0463 0.034 up no dn dn no up 20:0+blood 24:0+blood 0 0.799019608 0.434529915 yes serum_fattyacid serum_fattyacid 0.000278 0.034 dn no up dn no up 20:1-LPE+blood 24:0+blood 0 0.698529412 0 serum_phospholipids serum_fattyacid 0.465 0.034 no no no dn no up 20:1/20:4-PE+blood 24:0+blood 0.460150376 0 0 serum_phospholipids serum_fattyacid 0.0042 0.034 up up no dn no up 20:2-LPC+blood 24:0+blood 0 0.575980392 0 serum_phospholipids serum_fattyacid 0.119 0.034 no no up dn no up 20:2-LPE+blood 24:0+blood 0 0.607843137 0 serum_phospholipids serum_fattyacid 0.177 0.034 no no no dn no up 20:2+blood 24:0+blood 0 0.566176471 0 serum_fattyacid serum_fattyacid 0.478 0.034 no no no dn no up 20:3-LPC+blood 24:0+blood 0 0 0.452991453 serum_phospholipids serum_fattyacid 0.0292 0.034 no up no dn no up 20:3n6+blood 24:0+blood 0 0 0.457777778 serum_fattyacid serum_fattyacid 0.0884 0.034 up no no dn no up 20:4-LPE+blood 24:0+blood 0 0.639705882 0 serum_phospholipids serum_fattyacid 0.552 0.034 no no no dn no up Acute myeloid leukemia 24:0+blood -0.470175439 0 0 kegg serum_fattyacid NA 0.034 no no no dn no up Adipocytokine signaling pathway 24:0+blood -0.621052632 0 0 kegg serum_fattyacid NA 0.034 no no no dn no up Antigen processing and presentation 24:0+blood 0.512280702 0 0 kegg serum_fattyacid NA 0.034 no no no dn no up Bifidobacterium 24:0+blood 0.592704066 0 0 acetate-producing Genus serum_fattyacid 0.105 0.034 no dn no dn no up Biosynthesis of cofactors 24:0+blood 0 -0.541176471 0 kegg serum_fattyacid NA 0.034 no no no dn no up Gemmiger 24:0+blood 0 0.616709478 0 butyrate-producing Genus serum_fattyacid 0.595 0.034 no no no dn no up Glioma 24:0+blood 0 0 -0.445384615 kegg serum_fattyacid NA 0.034 no no no dn no up "Glycine, serine and threonine metabolism" 24:0+blood 0 -0.632352941 0 kegg serum_fattyacid NA 0.034 no up no dn no up "Growth hormone synthesis, secretion and action" 24:0+blood -0.524561404 0 0 kegg serum_fattyacid NA 0.034 no no no dn no up HCA+stool 24:0+blood 0 0 0.565413534 stool_bileacids serum_fattyacid 0.155 0.034 no no no dn no up Herpes simplex virus 1 infection 24:0+blood 0.468421053 0 0 kegg serum_fattyacid NA 0.034 no no no dn no up Human T-cell leukemia virus 1 infection 24:0+blood 0.512280702 0 0 kegg serum_fattyacid NA 0.034 no no no dn no up Kaposi sarcoma-associated herpesvirus infection 24:0+blood 0 0 0.405384615 kegg serum_fattyacid NA 0.034 no no dn dn no up L-Phenylalanine+stool 24:0+blood 0 -0.681818182 0 stool_cometabolism serum_fattyacid 0.398 0.034 no no no dn no up Lachnospira 24:0+blood -0.476691729 0 0 butyrate-producing Genus serum_fattyacid 0.279 0.034 no no no dn no up Longevity regulating pathway 24:0+blood -0.638596491 0 0 kegg serum_fattyacid NA 0.034 no no no dn no up Oocyte meiosis 24:0+blood 0.477192982 0 -0.403846154 kegg serum_fattyacid NA 0.034 no no no dn no up Paraprevotella 24:0+blood 0.664485781 0 0 Genus serum_fattyacid 0.118 0.034 no no no dn no up Porphyrin and chlorophyll metabolism 24:0+blood 0 -0.520588235 0 kegg serum_fattyacid NA 0.034 no no no dn no up Prevotella 24:0+blood 0.460374502 0 0 Genus serum_fattyacid 0.367 0.034 no no no dn no up Relaxin signaling pathway 24:0+blood -0.478947368 0 0 kegg serum_fattyacid NA 0.034 no no no dn no up Salmonella infection 24:0+blood 0.578947368 0 0 kegg serum_fattyacid NA 0.034 no no no dn no up 12-ketoDCA+blood 24:1+blood 0 -0.559840896 0 serum_bileacids serum_fattyacid 0.517 0.00582 no no no no dn dn 14:0-LPC+blood 24:1+blood 0 0 -0.414017094 serum_phospholipids serum_fattyacid 0.00689 0.00582 up up no no dn dn 16:0/14:0-PC+blood 24:1+blood 0.610526316 0 0.60957265 serum_phospholipids serum_fattyacid 0.0206 0.00582 no up up no dn dn 16:0/16:0-PC+blood 24:1+blood 0 0 0.507692308 serum_phospholipids serum_fattyacid 0.00079 0.00582 no up up no dn dn 16:0/18:1-PE+blood 24:1+blood -0.490225564 0 0 serum_phospholipids serum_fattyacid 0.000107 0.00582 up up no no dn dn 16:0/18:2-PC+blood 24:1+blood 0 0 0.498119658 serum_phospholipids serum_fattyacid 3.24E-06 0.00582 no up up no dn dn 16:0/20:4-PC+blood 24:1+blood 0.464661654 0 0 serum_phospholipids serum_fattyacid 0.0262 0.00582 no up no no dn dn 16:1/16:0-PC+blood 24:1+blood 0.613533835 0 0.578119658 serum_phospholipids serum_fattyacid 0.0215 0.00582 no up up no dn dn 16:1/16:1-PC+blood 24:1+blood 0.512781955 0 0.595897436 serum_phospholipids serum_fattyacid 0.0177 0.00582 no no up no dn dn 18:0-LPC+blood 24:1+blood 0 -0.490196078 0 serum_phospholipids serum_fattyacid 0.554 0.00582 no no no no dn dn 18:0/18:0-PE+blood 24:1+blood -0.505263158 0 -0.72034188 serum_phospholipids serum_fattyacid 0.00896 0.00582 up up no no dn dn 18:0/18:1-PE+blood 24:1+blood -0.593984962 0 -0.669059829 serum_phospholipids serum_fattyacid 0.00716 0.00582 up up no no dn dn 18:0/18:1-PG+blood 24:1+blood 0 0 -0.420854701 serum_phospholipids serum_fattyacid 0.000842 0.00582 no up no no dn dn 18:0/18:2-PC+blood 24:1+blood 0 0 0.567863248 serum_phospholipids serum_fattyacid 1.74E-06 0.00582 no up up no dn dn 18:0/22:6-PA+blood 24:1+blood 0.481203008 0 0 serum_phospholipids serum_fattyacid 0.22 0.00582 no no no no dn dn 18:1-LPE+blood 24:1+blood -0.535338346 0 0 serum_phospholipids serum_fattyacid 0.117 0.00582 no no no no dn dn 18:1/16:0-PC+blood 24:1+blood 0 0 0.502905983 serum_phospholipids serum_fattyacid 2.43E-05 0.00582 no up up no dn dn 18:1/16:0-PE+blood 24:1+blood -0.479699248 0 -0.470769231 serum_phospholipids serum_fattyacid 0.000182 0.00582 up up no no dn dn 18:1/16:1-PE+blood 24:1+blood -0.445112782 0 0 serum_phospholipids serum_fattyacid 0.000184 0.00582 up up no no dn dn 18:1/18:0-PC+blood 24:1+blood 0 0 0.591111111 serum_phospholipids serum_fattyacid 1.83E-06 0.00582 no up up no dn dn 18:1/18:0-PE+blood 24:1+blood -0.446616541 0 0 serum_phospholipids serum_fattyacid 1.39E-06 0.00582 up up no no dn dn 18:1/18:1-PE+blood 24:1+blood -0.478195489 0 0 serum_phospholipids serum_fattyacid 1.03E-05 0.00582 up up no no dn dn 18:1/18:2-PE+blood 24:1+blood -0.559398496 0 -0.403076923 serum_phospholipids serum_fattyacid 0.000293 0.00582 up up no no dn dn 18:1/20:4-PE+blood 24:1+blood 0 0 -0.452991453 serum_phospholipids serum_fattyacid 0.0578 0.00582 up no no no dn dn 18:1+blood 24:1+blood 0 0.651960784 0 yes serum_fattyacid serum_fattyacid 0.00202 0.00582 up no dn no dn dn 18:2/16:0-PC+blood 24:1+blood 0 0 0.429059829 serum_phospholipids serum_fattyacid 8.67E-05 0.00582 no up up no dn dn 18:3/16:0-PE+blood 24:1+blood -0.493233083 0 0 serum_phospholipids serum_fattyacid 0.00149 0.00582 up up no no dn dn 20:0/20:4-PE+blood 24:1+blood 0 0 -0.578803419 serum_phospholipids serum_fattyacid 0.00128 0.00582 up up no no dn dn 20:1-LPE+blood 24:1+blood -0.448120301 0 0 serum_phospholipids serum_fattyacid 0.465 0.00582 no no no no dn dn 20:1/20:4-PE+blood 24:1+blood 0 0 -0.45982906 serum_phospholipids serum_fattyacid 0.0042 0.00582 up up no no dn dn 20:2/18:1-PE+blood 24:1+blood -0.473684211 0 -0.485128205 serum_phospholipids serum_fattyacid 0.00208 0.00582 up up no no dn dn 20:3-LPE+blood 24:1+blood 0 -0.536764706 0 serum_phospholipids serum_fattyacid 0.084 0.00582 no up no no dn dn 20:3/16:0-PC+blood 24:1+blood 0.484210526 0 0 serum_phospholipids serum_fattyacid 0.00405 0.00582 no up up no dn dn 20:3/18:0-PC+blood 24:1+blood 0.52481203 0 0.679316239 serum_phospholipids serum_fattyacid 0.296 0.00582 no no no no dn dn 20:4-LPA+blood 24:1+blood 0 0 -0.472820513 serum_phospholipids serum_fattyacid 0.398 0.00582 no no no no dn dn Calcium signaling pathway 24:1+blood 0 -0.570588235 0 kegg serum_fattyacid NA 0.00582 no up up no dn dn DCA+stool 24:1+blood 0 0 -0.717293233 stool_bileacids serum_fattyacid 0.195 0.00582 no no no no dn dn Eggerthella 24:1+blood 0 0.507149988 0 Genus serum_fattyacid 0.912 0.00582 no no no no dn dn Estrogen signaling pathway 24:1+blood -0.522807018 0 0 kegg serum_fattyacid NA 0.00582 no no no no dn dn GCDCA+stool 24:1+blood 0 0 0.445112782 yes stool_bileacids serum_fattyacid 0.0471 0.00582 no dn no no dn dn GDCA+stool 24:1+blood 0 0 0.49548249 stool_bileacids serum_fattyacid 0.656 0.00582 no no no no dn dn Inflammatory bowel disease 24:1+blood 0.528070175 0 0 kegg serum_fattyacid NA 0.00582 no no no no dn dn LCA+stool 24:1+blood 0 0 -0.654135338 stool_bileacids serum_fattyacid 0.314 0.00582 no no no no dn dn Longevity regulating pathway - multiple species 24:1+blood 0 0.523529412 0 kegg serum_fattyacid NA 0.00582 no no no no dn dn Lysosome 24:1+blood 0.489473684 0 0 kegg serum_fattyacid NA 0.00582 no no no no dn dn Mineral absorption 24:1+blood 0 -0.588235294 0 kegg serum_fattyacid NA 0.00582 no no no no dn dn Morphine addiction 24:1+blood 0 -0.508823529 0 kegg serum_fattyacid NA 0.00582 no up up no dn dn Necroptosis 24:1+blood 0 -0.55 0 kegg serum_fattyacid NA 0.00582 no no no no dn dn Pancreatic cancer 24:1+blood 0 0 -0.619230769 kegg serum_fattyacid NA 0.00582 no no no no dn dn Prevotella 24:1+blood -0.48287664 0 0 acetate-producing Genus serum_fattyacid 0.287 0.00582 no no no no dn dn Propionic acid+stool 24:1+blood 0 0 -0.74887218 yes stool_scfa serum_fattyacid 0.0436 0.00582 dn no up no dn dn total_stool_scfa+stool 24:1+blood 0 0 -0.618045113 stool_scfa serum_fattyacid 0.0534 0.00582 dn no up no dn dn Adlercreutzia 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.478665697 Genus stool_cometabolism 0.548 0.33 no no no no no no AGE-RAGE signaling pathway in diabetic complications 3-(3-Hydroxyphenyl)propanoic acid+stool 0.609907121 0 0 kegg stool_cometabolism NA 0.33 no no no no no no Anaerostipes 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.425928134 butyrate-producing Genus stool_cometabolism 0.568 0.33 no no no no no no Bacteroides 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 0.448616601 LPS-producing Genus stool_cometabolism 0.000267 0.33 dn dn up no no no Carbon metabolism 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.444381705 kegg stool_cometabolism NA 0.33 no no no no no no Central carbon metabolism in cancer 3-(3-Hydroxyphenyl)propanoic acid+stool 0.529411765 0 0 kegg stool_cometabolism NA 0.33 no no no no no no Coprococcus 3-(3-Hydroxyphenyl)propanoic acid+stool 0.558307534 0 0 butyrate-producing Genus stool_cometabolism 0.612 0.33 no no no no no no Dorea 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0.755244755 0 Genus stool_cometabolism 0.00362 0.33 up no dn no no no ErbB signaling pathway 3-(3-Hydroxyphenyl)propanoic acid+stool 0.502579979 0 0 kegg stool_cometabolism NA 0.33 no no no no no no Fluid shear stress and atherosclerosis 3-(3-Hydroxyphenyl)propanoic acid+stool -0.519091847 0 0 kegg stool_cometabolism NA 0.33 no no no no no no FoxO signaling pathway 3-(3-Hydroxyphenyl)propanoic acid+stool 0.560371517 0 0 kegg stool_cometabolism NA 0.33 no no no no no no Gastric cancer 3-(3-Hydroxyphenyl)propanoic acid+stool 0.517027864 0 0 kegg stool_cometabolism NA 0.33 no no no no no no Lachnospira 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.468495196 butyrate-producing Genus stool_cometabolism 0.279 0.33 no no no no no no Longevity regulating pathway - multiple species 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.422924901 kegg stool_cometabolism NA 0.33 no no no no no no Platinum drug resistance 3-(3-Hydroxyphenyl)propanoic acid+stool 0.616099071 0 0 kegg stool_cometabolism NA 0.33 no no no no no no Primary immunodeficiency 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.427442123 kegg stool_cometabolism NA 0.33 no no no no no no Regulation of actin cytoskeleton 3-(3-Hydroxyphenyl)propanoic acid+stool -0.488132095 0 0 kegg stool_cometabolism NA 0.33 no no no no no no Roseburia 3-(3-Hydroxyphenyl)propanoic acid+stool -0.488132095 0 0 butyrate-producing Genus stool_cometabolism 0.495 0.33 no no no no no no Serotonergic synapse 3-(3-Hydroxyphenyl)propanoic acid+stool -0.504643963 0 0 kegg stool_cometabolism NA 0.33 no no no no no no Spliceosome 3-(3-Hydroxyphenyl)propanoic acid+stool 0.535603715 0 0 kegg stool_cometabolism NA 0.33 no no no no no no Tight junction 3-(3-Hydroxyphenyl)propanoic acid+stool -0.574819401 0 0 kegg stool_cometabolism NA 0.33 no no no no no no 15-HETE+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.482363244 serum_ARA urine_cometabolism 0.819 0.0125 no no no up up no 16:0-LPC+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.575324675 serum_phospholipids urine_cometabolism 0.00456 0.0125 up up no up up no 16:0/18:2-PI+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.437662338 serum_phospholipids urine_cometabolism 0.269 0.0125 no no no up up no 16:0/20:4-PI+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.546753247 serum_phospholipids urine_cometabolism 0.558 0.0125 no no no up up no 16:0+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0.571428571 0 yes serum_fattyacid urine_cometabolism 0.00876 0.0125 up no no up up no 18:0/16:0-PC+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 -0.436363636 serum_phospholipids urine_cometabolism 9.64E-07 0.0125 up up up up up no 18:0/18:2-PI+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.463636364 serum_phospholipids urine_cometabolism 0.179 0.0125 no no no up up no 18:1/20:3-PC+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0.487745098 0 0 serum_phospholipids urine_cometabolism 0.00872 0.0125 no up up up up no 18:1/20:4-PC+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 -0.442857143 serum_phospholipids urine_cometabolism 0.582 0.0125 no no no up up no 18:2n6c+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0.620879121 0 serum_fattyacid urine_cometabolism 0.15 0.0125 no no no up up no 2-hydroxyhippuric acid+urine "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 -0.408547009 urine_cometabolism urine_cometabolism 0.215 0.0125 no no no up up no 2-hydroxyphenylacetic acid+urine "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 -0.461403509 0 urine_cometabolism urine_cometabolism 0.763 0.0125 no no no up up no 20:3n6+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0.556372549 0 0 serum_fattyacid urine_cometabolism 0.0884 0.0125 up no no up up no Alcoholism "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.403846154 kegg urine_cometabolism NA 0.0125 no no no up up no Bacterial invasion of epithelial cells "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0.477192982 0 kegg urine_cometabolism NA 0.0125 no no no up up no Bacteroides "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0.721804511 0 0 LPS-producing Genus urine_cometabolism 0.000267 0.0125 dn dn up up up no Cardiac muscle contraction "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.412307692 kegg urine_cometabolism NA 0.0125 no no up up up no Circadian entrainment "3-(3,4-dihydroxyphenyl)propionic acid+urine" -0.466666667 0 0 kegg urine_cometabolism NA 0.0125 no up up up up no Cocaine addiction "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.443846154 kegg urine_cometabolism NA 0.0125 no no no up up no Cortisol synthesis and secretion "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.430769231 kegg urine_cometabolism NA 0.0125 no no up up up no d18:1-14:0-SM+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0.50245098 0 0.490909091 serum_phospholipids urine_cometabolism 0.94 0.0125 no no no up up no d18:1-16:1-SM+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.528571429 serum_phospholipids urine_cometabolism 0.2 0.0125 no no no up up no d18:1-18:1-SM+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.454545455 serum_phospholipids urine_cometabolism 0.916 0.0125 no no no up up no d18:1-20:0-SM+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.511688312 serum_phospholipids urine_cometabolism 0.933 0.0125 no no no up up no DPA+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 -0.507792208 serum_ARA urine_cometabolism 0.519 0.0125 no no no up up no Ferroptosis "3-(3,4-dihydroxyphenyl)propionic acid+urine" -0.494736842 0 0 kegg urine_cometabolism NA 0.0125 no no no up up no Fluid shear stress and atherosclerosis "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0.459649123 0 kegg urine_cometabolism NA 0.0125 no no no up up no Gastric cancer "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0.519298246 0 0 kegg urine_cometabolism NA 0.0125 no no no up up no Glutamatergic synapse "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.406153846 kegg urine_cometabolism NA 0.0125 no up up up up no Hepatocellular carcinoma "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0.468421053 0 kegg urine_cometabolism NA 0.0125 no no no up up no Huntington disease "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.436153846 kegg urine_cometabolism NA 0.0125 no no no up up no Hypertrophic cardiomyopathy "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0.468421053 0 kegg urine_cometabolism NA 0.0125 no up up up up no L-Citrulline+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 -0.626373626 0 serum_aminoacids urine_cometabolism 0.534 0.0125 no no no up up no L-Lysine+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 -0.60989011 0 yes serum_aminoacids urine_cometabolism 0.0107 0.0125 no up no up up no L-Methionine+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 -0.448051948 serum_aminoacids urine_cometabolism 0.626 0.0125 no no no up up no L-Tryptophan+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 -0.5 serum_aminoacids urine_cometabolism 0.164 0.0125 no no no up up no Leukocyte transendothelial migration "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0.464912281 0 kegg urine_cometabolism NA 0.0125 no no no up up no Long-term depression "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.433076923 kegg urine_cometabolism NA 0.0125 no no no up up no Morphine addiction "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.469230769 kegg urine_cometabolism NA 0.0125 no up up up up no n6+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0.49754902 0 0 serum_fattyacid urine_cometabolism 0.153 0.0125 no no no up up no NF-kappa B signaling pathway "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0.456140351 0 0 kegg urine_cometabolism NA 0.0125 no no no up up no Non-alcoholic fatty liver disease "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.459230769 kegg urine_cometabolism NA 0.0125 no no no up up no Oxidative phosphorylation "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.423846154 kegg urine_cometabolism NA 0.0125 no no no up up no "Parathyroid hormone synthesis, secretion and action" "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.432307692 kegg urine_cometabolism NA 0.0125 no no no up up no Parkinson disease "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.440769231 kegg urine_cometabolism NA 0.0125 no no no up up no Pathways of neurodegeneration - multiple diseases "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.445384615 kegg urine_cometabolism NA 0.0125 no no no up up no Platelet activation "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0.473684211 0 kegg urine_cometabolism NA 0.0125 no no no up up no Rap1 signaling pathway "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0.51754386 0 kegg urine_cometabolism NA 0.0125 no no no up up no Salivary secretion "3-(3,4-dihydroxyphenyl)propionic acid+urine" -0.457894737 0.552631579 0 kegg urine_cometabolism NA 0.0125 no no no up up no Serotonergic synapse "3-(3,4-dihydroxyphenyl)propionic acid+urine" -0.510526316 0 0 kegg urine_cometabolism NA 0.0125 no no no up up no TCA+blood "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0.504236056 0 0 serum_bileacids urine_cometabolism 0.339 0.0125 no no no up up no Thermogenesis "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.420769231 kegg urine_cometabolism NA 0.0125 no no no up up no 2-hydroxyhippuric acid+urine 3-Hydroxy-L-kynurenine+urine -0.494736842 -0.498245614 -0.478290598 urine_cometabolism urine_cometabolism 0.215 0.401 no no no no no no 2-hydroxyphenylacetic acid+urine 3-Hydroxy-L-kynurenine+urine 0 -0.515789474 0 urine_cometabolism urine_cometabolism 0.763 0.401 no no no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" 3-Hydroxy-L-kynurenine+urine 0 0.592982456 0.667692308 urine_cometabolism urine_cometabolism 0.0125 0.401 up up no no no no 2-hydroxyhippuric acid+urine 3-Hydroxytyramine hydrochloride+urine 0 0 -0.557606838 urine_cometabolism urine_cometabolism 0.215 0.288 no no no no no no 2-hydroxyphenylacetic acid+urine 3-Hydroxytyramine hydrochloride+urine 0 0 -0.526837607 urine_cometabolism urine_cometabolism 0.763 0.288 no no no no no no 12-ketoDCA+blood 4-hydroxy-3-methoxymandelic acid+urine -0.517029533 0 0 serum_bileacids urine_cometabolism 0.517 0.973 no no no no no no 16:0/18:2-PI+blood 4-hydroxy-3-methoxymandelic acid+urine 0 0.582417582 0 serum_phospholipids urine_cometabolism 0.269 0.973 no no no no no no 16:0/20:4-PC+blood 4-hydroxy-3-methoxymandelic acid+urine 0 -0.653846154 0 serum_phospholipids urine_cometabolism 0.0262 0.973 no up no no no no 16:0/22:6-PC+blood 4-hydroxy-3-methoxymandelic acid+urine 0 -0.60989011 0 serum_phospholipids urine_cometabolism 4.53E-05 0.973 no up up no no no 18:0/18:0-PC+blood 4-hydroxy-3-methoxymandelic acid+urine 0 0 0.493506494 serum_phospholipids urine_cometabolism 0.426 0.973 no no no no no no 18:0/18:1-PC+blood 4-hydroxy-3-methoxymandelic acid+urine 0 0 0.464935065 serum_phospholipids urine_cometabolism 0.393 0.973 no no no no no no 18:0/18:1-PE+blood 4-hydroxy-3-methoxymandelic acid+urine 0 0.703296703 0 serum_phospholipids urine_cometabolism 0.00716 0.973 up up no no no no 18:0/20:3-PC+blood 4-hydroxy-3-methoxymandelic acid+urine 0 0 0.592207792 serum_phospholipids urine_cometabolism 0.0682 0.973 no up no no no no 18:0/20:4-PC+blood 4-hydroxy-3-methoxymandelic acid+urine 0 -0.631868132 0 serum_phospholipids urine_cometabolism 0.454 0.973 no no no no no no 18:0/22:6-PA+blood 4-hydroxy-3-methoxymandelic acid+urine 0 -0.637362637 0 serum_phospholipids urine_cometabolism 0.22 0.973 no no no no no no 20:2/18:0-PC+blood 4-hydroxy-3-methoxymandelic acid+urine 0 0 0.561038961 serum_phospholipids urine_cometabolism 0.0427 0.973 no up no no no no 20:3/16:0-PC+blood 4-hydroxy-3-methoxymandelic acid+urine 0 -0.659340659 0 serum_phospholipids urine_cometabolism 0.00405 0.973 no up up no no no 20:3/18:0-PC+blood 4-hydroxy-3-methoxymandelic acid+urine 0 -0.736263736 0 serum_phospholipids urine_cometabolism 0.296 0.973 no no no no no no 20:3n6+blood 4-hydroxy-3-methoxymandelic acid+urine 0 0 0.444155844 serum_fattyacid urine_cometabolism 0.0884 0.973 up no no no no no 20:4n6+blood 4-hydroxy-3-methoxymandelic acid+urine 0 -0.675824176 0.524675325 serum_fattyacid urine_cometabolism 0.133 0.973 no no no no no no 20:5/18:0-PC+blood 4-hydroxy-3-methoxymandelic acid+urine 0 -0.708791209 0 serum_phospholipids urine_cometabolism 3.97E-06 0.973 no up up no no no 3-Hydroxytyramine hydrochloride+urine 4-hydroxy-3-methoxymandelic acid+urine 0.557894737 0 0.435897436 urine_cometabolism urine_cometabolism 0.288 0.973 no no no no no no Arginine and proline metabolism 4-hydroxy-3-methoxymandelic acid+urine 0.556140351 0 0.424615385 kegg urine_cometabolism NA 0.973 no up no no no no Axon guidance 4-hydroxy-3-methoxymandelic acid+urine -0.485964912 0.515789474 0 kegg urine_cometabolism NA 0.973 no up up no no no Cushing syndrome 4-hydroxy-3-methoxymandelic acid+urine -0.471929825 0 0 kegg urine_cometabolism NA 0.973 no no up no no no DHA+blood 4-hydroxy-3-methoxymandelic acid+urine 0 -0.637362637 0 serum_ARA urine_cometabolism 0.872 0.973 no no no no no no DL-methionine sulfoxide+blood 4-hydroxy-3-methoxymandelic acid+urine -0.534313725 0 0 serum_aminoacids urine_cometabolism 0.302 0.973 no no no no no no Dorea 4-hydroxy-3-methoxymandelic acid+urine 0.496240602 0 0 Genus urine_cometabolism 0.00362 0.973 up no dn no no no FoxO signaling pathway 4-hydroxy-3-methoxymandelic acid+urine 0 0 -0.469230769 kegg urine_cometabolism NA 0.973 no no no no no no Gastric cancer 4-hydroxy-3-methoxymandelic acid+urine 0 0 -0.401538462 kegg urine_cometabolism NA 0.973 no no no no no no L-2-Aminobutyric acid+blood 4-hydroxy-3-methoxymandelic acid+urine 0 -0.554945055 0.476623377 yes serum_aminoacids urine_cometabolism 0.000328 0.973 up up no no no no L-Aspartic acid+blood 4-hydroxy-3-methoxymandelic acid+urine 0 -0.565934066 0 yes serum_aminoacids urine_cometabolism 0.0226 0.973 up up no no no no L-Proline+blood 4-hydroxy-3-methoxymandelic acid+urine 0 0.763736264 0 yes serum_aminoacids urine_cometabolism 0.00265 0.973 up up no no no no Lysosome 4-hydroxy-3-methoxymandelic acid+urine 0 0.470175439 0 kegg urine_cometabolism NA 0.973 no no no no no no n6+blood 4-hydroxy-3-methoxymandelic acid+urine 0.654411765 0 0 serum_fattyacid urine_cometabolism 0.153 0.973 no no no no no no NOD-like receptor signaling pathway 4-hydroxy-3-methoxymandelic acid+urine 0.478947368 0 0 kegg urine_cometabolism NA 0.973 no no no no no no Odoribacter 4-hydroxy-3-methoxymandelic acid+urine 0 0 -0.575887103 butyrate-producing Genus urine_cometabolism 0.798 0.973 no no no no no no p53 signaling pathway 4-hydroxy-3-methoxymandelic acid+urine 0 -0.470175439 0 kegg urine_cometabolism NA 0.973 no no no no no no Pancreatic cancer 4-hydroxy-3-methoxymandelic acid+urine 0 0 -0.499230769 kegg urine_cometabolism NA 0.973 no no no no no no Parabacteroides 4-hydroxy-3-methoxymandelic acid+urine 0 -0.657894737 0 Genus urine_cometabolism 4.19E-05 0.973 no up up no no no Peroxisome 4-hydroxy-3-methoxymandelic acid+urine 0.538596491 0 0 kegg urine_cometabolism NA 0.973 no no no no no no Pertussis 4-hydroxy-3-methoxymandelic acid+urine 0.466666667 0 0 kegg urine_cometabolism NA 0.973 no no dn no no no PUFA+blood 4-hydroxy-3-methoxymandelic acid+urine 0.529411765 0 0 serum_fattyacid urine_cometabolism 0.212 0.973 no no no no no no Renal cell carcinoma 4-hydroxy-3-methoxymandelic acid+urine -0.468421053 0 0 kegg urine_cometabolism NA 0.973 no no no no no no Roseburia 4-hydroxy-3-methoxymandelic acid+urine 0.526315789 0 0 butyrate-producing Genus urine_cometabolism 0.495 0.973 no no no no no no TCA+stool 4-hydroxy-3-methoxymandelic acid+urine 0 0.711303297 0 stool_bileacids urine_cometabolism 0.458 0.973 no no no no no no TLCA+stool 4-hydroxy-3-methoxymandelic acid+urine -0.580858437 0 0 stool_bileacids urine_cometabolism 0.243 0.973 no no no no no no Wnt signaling pathway 4-hydroxy-3-methoxymandelic acid+urine -0.470175439 0 0 kegg urine_cometabolism NA 0.973 no no no no no no AGE-RAGE signaling pathway in diabetic complications 4-hydroxybenzoic acid+stool 0 0 -0.517786561 kegg stool_cometabolism NA 0.0536 no no no no dn no Akkermansia 4-hydroxybenzoic acid+stool 0 0 -0.438823652 acetate-producing Genus stool_cometabolism 0.23 0.0536 no no no no dn no Alistipes 4-hydroxybenzoic acid+stool -0.54084914 0 0 Genus stool_cometabolism 0.0114 0.0536 no up no no dn no Alzheimer disease 4-hydroxybenzoic acid+stool 0 0 0.428571429 kegg stool_cometabolism NA 0.0536 no no no no dn no Axon guidance 4-hydroxybenzoic acid+stool 0 0 0.43308865 kegg stool_cometabolism NA 0.0536 no up up no dn no Faecalibacterium 4-hydroxybenzoic acid+stool 0.490196078 0 0 butyrate-producing Genus stool_cometabolism 0.0039 0.0536 no dn dn no dn no JAK-STAT signaling pathway 4-hydroxybenzoic acid+stool 0 0 -0.435347261 kegg stool_cometabolism NA 0.0536 no no no no dn no Neutrophil extracellular trap formation 4-hydroxybenzoic acid+stool 0.469556244 0 0 kegg stool_cometabolism NA 0.0536 no no no no dn no NF-kappa B signaling pathway 4-hydroxybenzoic acid+stool 0 0 -0.523433089 kegg stool_cometabolism NA 0.0536 no no no no dn no Oscillospira 4-hydroxybenzoic acid+stool -0.704850361 0 -0.526679842 LPS-producing Genus stool_cometabolism 0.62 0.0536 no no no no dn no Pathways in cancer 4-hydroxybenzoic acid+stool 0 0 -0.442123094 kegg stool_cometabolism NA 0.0536 no no no no dn no Ras signaling pathway 4-hydroxybenzoic acid+stool 0.502579979 0 0 yes kegg stool_cometabolism NA 0.0536 no up up no dn no RIG-I-like receptor signaling pathway 4-hydroxybenzoic acid+stool 0 0 -0.459062676 kegg stool_cometabolism NA 0.0536 no no no no dn no Ruminococcus 4-hydroxybenzoic acid+stool -0.560371517 0 0 acetate-producing Genus stool_cometabolism 0.335 0.0536 no no no no dn no Small cell lung cancer 4-hydroxybenzoic acid+stool 0 0 -0.435347261 kegg stool_cometabolism NA 0.0536 no no up no dn no 12-ketoDCA+stool 4-hydroxybenzoic acid+urine 0 0 -0.570691434 stool_bileacids urine_cometabolism 0.505 0.52 no no no no no no "12,13-EPOME+blood" 4-hydroxybenzoic acid+urine 0 0 -0.43841761 serum_ARA urine_cometabolism 0.901 0.52 no no no no no no 13-HODE+blood 4-hydroxybenzoic acid+urine 0 0 -0.441558442 serum_ARA urine_cometabolism 0.32 0.52 no no no no no no 16:0/18:1-PC+blood 4-hydroxybenzoic acid+urine 0 0 -0.471428571 serum_phospholipids urine_cometabolism 6.15E-07 0.52 up up up no no no 16:0/18:3-PC+blood 4-hydroxybenzoic acid+urine 0 0.56043956 0 serum_phospholipids urine_cometabolism 0.00216 0.52 no up up no no no 16:0+blood 4-hydroxybenzoic acid+urine 0 0 -0.525974026 yes serum_fattyacid urine_cometabolism 0.00876 0.52 up no no no no no 16:1+blood 4-hydroxybenzoic acid+urine 0 -0.664835165 0 yes serum_fattyacid urine_cometabolism 0.0186 0.52 no no dn no no no 18:1/18:2-PG+blood 4-hydroxybenzoic acid+urine 0 -0.637362637 0 serum_phospholipids urine_cometabolism 5.58E-07 0.52 no up up no no no 22:6n3+blood 4-hydroxybenzoic acid+urine 0 0 -0.449350649 serum_fattyacid urine_cometabolism 0.792 0.52 no no no no no no 3-Hydroxytyramine hydrochloride+urine 4-hydroxybenzoic acid+urine 0 0 -0.565811966 urine_cometabolism urine_cometabolism 0.288 0.52 no no no no no no Bacteroides 4-hydroxybenzoic acid+urine 0 0.5 0 LPS-producing Genus urine_cometabolism 0.000267 0.52 dn dn up no no no Choline metabolism in cancer 4-hydroxybenzoic acid+urine 0 -0.477192982 0 kegg urine_cometabolism NA 0.52 no no no no no no Colorectal cancer 4-hydroxybenzoic acid+urine 0 -0.677192982 0 kegg urine_cometabolism NA 0.52 no no no no no no d18:1-20:1-SM+blood 4-hydroxybenzoic acid+urine 0 0 0.557142857 serum_phospholipids urine_cometabolism 0.0992 0.52 no no no no no no Gastric cancer 4-hydroxybenzoic acid+urine 0 -0.492982456 0 kegg urine_cometabolism NA 0.52 no no no no no no GCDCA+blood 4-hydroxybenzoic acid+urine 0 0 0.435064935 serum_bileacids urine_cometabolism 0.31 0.52 no no no no no no Glycine+blood 4-hydroxybenzoic acid+urine 0 0.576923077 0 serum_aminoacids urine_cometabolism 0.00408 0.52 dn no up no no no HDCA+stool 4-hydroxybenzoic acid+urine 0 0 -0.570691434 stool_bileacids urine_cometabolism 0.176 0.52 no no no no no no L-Arginine+blood 4-hydroxybenzoic acid+urine 0 0.60989011 0 serum_aminoacids urine_cometabolism 0.316 0.52 no no no no no no L-Aspartic acid+blood 4-hydroxybenzoic acid+urine 0 0.554945055 0 yes serum_aminoacids urine_cometabolism 0.0226 0.52 up up no no no no Legionellosis 4-hydroxybenzoic acid+urine 0 0.466666667 0 kegg urine_cometabolism NA 0.52 no no no no no no Leishmaniasis 4-hydroxybenzoic acid+urine 0 0.470175439 0 kegg urine_cometabolism NA 0.52 no no no no no no n3+blood 4-hydroxybenzoic acid+urine 0 0 -0.485714286 serum_fattyacid urine_cometabolism 0.806 0.52 no no no no no no Phosphatidylinositol signaling system 4-hydroxybenzoic acid+urine 0 -0.484210526 0 kegg urine_cometabolism NA 0.52 no no no no no no PUFA/MUFA+blood 4-hydroxybenzoic acid+urine 0 0.637362637 0 serum_fattyacid urine_cometabolism 0.00108 0.52 dn no up no no no SFA+blood 4-hydroxybenzoic acid+urine 0 0 -0.527272727 serum_fattyacid urine_cometabolism 0.0386 0.52 up no no no no no Signaling pathways regulating pluripotency of stem cells 4-hydroxybenzoic acid+urine 0 -0.521052632 0 kegg urine_cometabolism NA 0.52 no no no no no no Taurine+blood 4-hydroxybenzoic acid+urine 0 0 -0.497402597 serum_aminoacids urine_cometabolism 0.857 0.52 no no no no no no ToFA+blood 4-hydroxybenzoic acid+urine 0 0 -0.433766234 serum_fattyacid urine_cometabolism 0.0307 0.52 up no dn no no no "12,13-EPOME+blood" 4-Hydroxyphenylacetic acid+urine 0 0.576501251 0 serum_ARA urine_cometabolism 0.901 0.0321 no no no up up no 16:0/18:0-PS+blood 4-Hydroxyphenylacetic acid+urine 0 0 -0.554545455 serum_phospholipids urine_cometabolism 0.377 0.0321 no no no up up no 16:0/18:1-PC+blood 4-Hydroxyphenylacetic acid+urine -0.566176471 0 0 serum_phospholipids urine_cometabolism 6.15E-07 0.0321 up up up up up no 18:0-LPC+blood 4-Hydroxyphenylacetic acid+urine 0.517156863 0 0 serum_phospholipids urine_cometabolism 0.554 0.0321 no no no up up no 18:0-LPE+blood 4-Hydroxyphenylacetic acid+urine 0.610294118 0 0 serum_phospholipids urine_cometabolism 0.491 0.0321 no no no up up no 18:0/16:0-PC+blood 4-Hydroxyphenylacetic acid+urine -0.580882353 0 0 serum_phospholipids urine_cometabolism 9.64E-07 0.0321 up up up up up no 18:0/18:0-PS+blood 4-Hydroxyphenylacetic acid+urine 0 0 -0.590909091 serum_phospholipids urine_cometabolism 0.00617 0.0321 no up no up up no 18:0/18:1-PE+blood 4-Hydroxyphenylacetic acid+urine 0.531862745 0 0 serum_phospholipids urine_cometabolism 0.00716 0.0321 up up no up up no 18:0/20:2-PC+blood 4-Hydroxyphenylacetic acid+urine 0.512254902 0 0 serum_phospholipids urine_cometabolism 0.733 0.0321 no no no up up no 18:0/20:3-PC+blood 4-Hydroxyphenylacetic acid+urine 0.553921569 0 0 serum_phospholipids urine_cometabolism 0.0682 0.0321 no up no up up no 18:0/20:4-PI+blood 4-Hydroxyphenylacetic acid+urine 0 0 -0.727272727 serum_phospholipids urine_cometabolism 0.167 0.0321 no no no up up no 18:0/22:6-PA+blood 4-Hydroxyphenylacetic acid+urine 0 0 -0.515584416 serum_phospholipids urine_cometabolism 0.22 0.0321 no no no up up no 18:0+blood 4-Hydroxyphenylacetic acid+urine 0.566176471 0 0 serum_fattyacid urine_cometabolism 0.344 0.0321 no no no up up no 18:1/18:2-PI+blood 4-Hydroxyphenylacetic acid+urine 0 0 0.653246753 serum_phospholipids urine_cometabolism 0.0164 0.0321 dn no up up up no 2-hydroxyphenylacetic acid+urine 4-Hydroxyphenylacetic acid+urine 0 0 0.437948718 urine_cometabolism urine_cometabolism 0.763 0.0321 no no no up up no 20:2/18:0-PC+blood 4-Hydroxyphenylacetic acid+urine 0.580882353 0 0 serum_phospholipids urine_cometabolism 0.0427 0.0321 no up no up up no 20:4/18:0-PE+blood 4-Hydroxyphenylacetic acid+urine 0 0 -0.509090909 serum_phospholipids urine_cometabolism 0.000755 0.0321 up up no up up no 22:6n3+blood 4-Hydroxyphenylacetic acid+urine 0.637254902 0 0 serum_fattyacid urine_cometabolism 0.792 0.0321 no no no up up no Apoptosis 4-Hydroxyphenylacetic acid+urine 0 0 0.403846154 kegg urine_cometabolism NA 0.0321 no no no up up no Arachidonic acid metabolism 4-Hydroxyphenylacetic acid+urine 0 0 0.463076923 kegg urine_cometabolism NA 0.0321 no no no up up no Autophagy - animal 4-Hydroxyphenylacetic acid+urine 0 0 -0.46 kegg urine_cometabolism NA 0.0321 no no no up up no Axon guidance 4-Hydroxyphenylacetic acid+urine 0 0 -0.486153846 kegg urine_cometabolism NA 0.0321 no up up up up no Breast cancer 4-Hydroxyphenylacetic acid+urine 0 0 -0.429230769 kegg urine_cometabolism NA 0.0321 no no no up up no Central carbon metabolism in cancer 4-Hydroxyphenylacetic acid+urine 0 0 -0.429230769 kegg urine_cometabolism NA 0.0321 no no no up up no Choline metabolism in cancer 4-Hydroxyphenylacetic acid+urine 0 0 -0.409230769 kegg urine_cometabolism NA 0.0321 no no no up up no Cytokine-cytokine receptor interaction 4-Hydroxyphenylacetic acid+urine 0 0 0.474615385 kegg urine_cometabolism NA 0.0321 no no no up up no d18:1-24:1-SM+blood 4-Hydroxyphenylacetic acid+urine 0 -0.576923077 0 serum_phospholipids urine_cometabolism 0.0123 0.0321 no dn dn up up no DCA+stool 4-Hydroxyphenylacetic acid+urine 0 -0.866666667 0 stool_bileacids urine_cometabolism 0.195 0.0321 no no no up up no Eggerthella 4-Hydroxyphenylacetic acid+urine 0 0.488861724 0 Genus urine_cometabolism 0.912 0.0321 no no no up up no ErbB signaling pathway 4-Hydroxyphenylacetic acid+urine 0 0 -0.556153846 kegg urine_cometabolism NA 0.0321 no no no up up no Glioma 4-Hydroxyphenylacetic acid+urine 0 0 -0.443846154 kegg urine_cometabolism NA 0.0321 no no no up up no Glutathione metabolism 4-Hydroxyphenylacetic acid+urine 0 0 0.455384615 kegg urine_cometabolism NA 0.0321 no no no up up no HDCA+stool 4-Hydroxyphenylacetic acid+urine -0.56043956 -0.766666667 0 stool_bileacids urine_cometabolism 0.176 0.0321 no no no up up no Herpes simplex virus 1 infection 4-Hydroxyphenylacetic acid+urine -0.484210526 0 0 kegg urine_cometabolism NA 0.0321 no no no up up no Human T-cell leukemia virus 1 infection 4-Hydroxyphenylacetic acid+urine -0.475438596 0 0 kegg urine_cometabolism NA 0.0321 no no no up up no iso-LCA+blood 4-Hydroxyphenylacetic acid+urine -0.503325555 0 0 serum_bileacids urine_cometabolism 0.507 0.0321 no no no up up no iso-LCA+stool 4-Hydroxyphenylacetic acid+urine 0 -0.766666667 0 stool_bileacids urine_cometabolism 0.72 0.0321 no no no up up no L-Aspartic acid+blood 4-Hydroxyphenylacetic acid+urine -0.531862745 0 0 yes serum_aminoacids urine_cometabolism 0.0226 0.0321 up up no up up no L-Histidine+blood 4-Hydroxyphenylacetic acid+urine -0.517156863 0 0 serum_aminoacids urine_cometabolism 0.109 0.0321 no no no up up no L-Phenylalanine+stool 4-Hydroxyphenylacetic acid+urine 0.556043956 0.733333333 0 stool_cometabolism urine_cometabolism 0.398 0.0321 no no no up up no L-Threonine+blood 4-Hydroxyphenylacetic acid+urine 0 0 -0.549350649 serum_aminoacids urine_cometabolism 0.0538 0.0321 dn no up up up no L-Tryptophan+stool 4-Hydroxyphenylacetic acid+urine 0.538461538 0.85 0 stool_cometabolism urine_cometabolism 0.557 0.0321 no no no up up no Lachnospira 4-Hydroxyphenylacetic acid+urine 0.472180451 0 0 butyrate-producing Genus urine_cometabolism 0.279 0.0321 no no no up up no LCA+blood 4-Hydroxyphenylacetic acid+urine -0.531791268 0 0 serum_bileacids urine_cometabolism 0.884 0.0321 no no no up up no LCA+stool 4-Hydroxyphenylacetic acid+urine 0 -0.8 0 stool_bileacids urine_cometabolism 0.314 0.0321 no no no up up no MAPK signaling pathway 4-Hydroxyphenylacetic acid+urine 0 0 -0.614615385 kegg urine_cometabolism NA 0.0321 no no no up up no MicroRNAs in cancer 4-Hydroxyphenylacetic acid+urine 0 0 -0.452307692 kegg urine_cometabolism NA 0.0321 no no no up up no n3+blood 4-Hydroxyphenylacetic acid+urine 0.522058824 0 0 serum_fattyacid urine_cometabolism 0.806 0.0321 no no no up up no n6/n3+blood 4-Hydroxyphenylacetic acid+urine -0.610294118 0 0 serum_fattyacid urine_cometabolism 0.226 0.0321 no no no up up no Propionic acid+stool 4-Hydroxyphenylacetic acid+urine 0 0 -0.599587203 yes stool_scfa urine_cometabolism 0.0436 0.0321 dn no up up up no PUFA+blood 4-Hydroxyphenylacetic acid+urine 0.507352941 0 0 serum_fattyacid urine_cometabolism 0.212 0.0321 no no no up up no Renal cell carcinoma 4-Hydroxyphenylacetic acid+urine 0 0 -0.402307692 kegg urine_cometabolism NA 0.0321 no no no up up no Renin secretion 4-Hydroxyphenylacetic acid+urine 0 0 0.41 kegg urine_cometabolism NA 0.0321 no no no up up no Signaling pathways regulating pluripotency of stem cells 4-Hydroxyphenylacetic acid+urine 0 0 -0.43 kegg urine_cometabolism NA 0.0321 no no no up up no Sphingolipid signaling pathway 4-Hydroxyphenylacetic acid+urine 0 0 -0.413846154 kegg urine_cometabolism NA 0.0321 no no no up up no Spinocerebellar ataxia 4-Hydroxyphenylacetic acid+urine 0 0 -0.415384615 kegg urine_cometabolism NA 0.0321 no no no up up no T cell receptor signaling pathway 4-Hydroxyphenylacetic acid+urine 0 0 -0.493076923 kegg urine_cometabolism NA 0.0321 no no no up up no TCA+stool 4-Hydroxyphenylacetic acid+urine 0 0 0.593395253 stool_bileacids urine_cometabolism 0.458 0.0321 no no no up up no Thyroid hormone synthesis 4-Hydroxyphenylacetic acid+urine 0 0 0.446153846 kegg urine_cometabolism NA 0.0321 no no no up up no TUDCA+blood 4-Hydroxyphenylacetic acid+urine 0.550899665 0 0 yes serum_bileacids urine_cometabolism 0.0282 0.0321 no no dn up up no Viral protein interaction with cytokine and cytokine receptor 4-Hydroxyphenylacetic acid+urine 0 0 0.411538462 kegg urine_cometabolism NA 0.0321 no no no up up no 14:0/18:0-PC+blood 5-HETE+blood 0 0 -0.422300941 serum_phospholipids serum_ARA 0.00289 0.697 up up no no no no 14:0/20:4-PC+blood 5-HETE+blood 0 -0.482269873 0 serum_phospholipids serum_ARA 0.486 0.697 no no no no no no 15-HETE+blood 5-HETE+blood 0.643350658 0 0 serum_ARA serum_ARA 0.819 0.697 no no no no no no 16:0/16:0-PC+blood 5-HETE+blood 0 0.630082458 0 serum_phospholipids serum_ARA 0.00079 0.697 no up up no no no 16:0/16:0-PI+blood 5-HETE+blood -0.572079545 0 0 serum_phospholipids serum_ARA 0.358 0.697 no no no no no no 16:0/16:1-PI+blood 5-HETE+blood -0.556230375 0 0 serum_phospholipids serum_ARA 0.262 0.697 no no no no no no 16:0/18:1-PC+blood 5-HETE+blood 0.492078975 0 0 serum_phospholipids serum_ARA 6.15E-07 0.697 up up up no no no 16:0/18:1-PE+blood 5-HETE+blood -0.560003987 0 0 serum_phospholipids serum_ARA 0.000107 0.697 up up no no no no 16:0/18:2-PC+blood 5-HETE+blood 0.554720931 0 0 serum_phospholipids serum_ARA 3.24E-06 0.697 no up up no no no 16:0/18:2-PI+blood 5-HETE+blood -0.518494258 0 0 serum_phospholipids serum_ARA 0.269 0.697 no no no no no no 16:0/20:3-PC+blood 5-HETE+blood 0 0 -0.409950954 serum_phospholipids serum_ARA 5.43E-06 0.697 no up up no no no 16:0/20:4-PI+blood 5-HETE+blood -0.492078975 0 0 serum_phospholipids serum_ARA 0.558 0.697 no no no no no no 16:0/20:5-PC+blood 5-HETE+blood 0 0 0.479934213 serum_phospholipids serum_ARA 0.628 0.697 no no no no no no 16:0/22:0-PE+blood 5-HETE+blood 0.538117039 0 0 serum_phospholipids serum_ARA 0.00839 0.697 dn no up no no no 16:0/22:6-PC+blood 5-HETE+blood 0.563022877 0 0 serum_phospholipids serum_ARA 4.53E-05 0.697 no up up no no no 18:0/16:0-PC+blood 5-HETE+blood 0.483777029 0 0 serum_phospholipids serum_ARA 9.64E-07 0.697 up up up no no no 18:0/18:2-PC+blood 5-HETE+blood 0.504909255 0 0 serum_phospholipids serum_ARA 1.74E-06 0.697 no up up no no no 18:0/18:2-PI+blood 5-HETE+blood -0.458871192 0 0 serum_phospholipids serum_ARA 0.179 0.697 no no no no no no 18:0/20:5-PC+blood 5-HETE+blood 0.826420978 0 0 serum_phospholipids serum_ARA 0.17 0.697 no no no no no no 18:1/16:0-PC+blood 5-HETE+blood 0.531324538 0 0 serum_phospholipids serum_ARA 2.43E-05 0.697 no up up no no no 18:1/16:0-PE+blood 5-HETE+blood -0.476984528 0 0 serum_phospholipids serum_ARA 0.000182 0.697 up up no no no no 18:1/16:0-PI+blood 5-HETE+blood -0.531324538 0 0 serum_phospholipids serum_ARA 0.793 0.697 no no no no no no 18:1/16:1-PE+blood 5-HETE+blood -0.495852587 0 0 serum_phospholipids serum_ARA 0.000184 0.697 up up no no no no 18:1/18:0-PC+blood 5-HETE+blood 0.536607594 0 0 serum_phospholipids serum_ARA 1.83E-06 0.697 no up up no no no 18:1/18:1-PC+blood 5-HETE+blood 0 0 -0.410637065 serum_phospholipids serum_ARA 1.34E-05 0.697 no up up no no no 18:1/22:6-PE+blood 5-HETE+blood 0 0 0.451803688 serum_phospholipids serum_ARA 0.0047 0.697 no up no no no no 18:2/18:2-PS+blood 5-HETE+blood -0.524532037 0 0 serum_phospholipids serum_ARA 0.00674 0.697 up up no no no no 18:2/20:4-PC+blood 5-HETE+blood 0.473965639 0 0 serum_phospholipids serum_ARA 0.0145 0.697 no no up no no no 18:3n6+blood 5-HETE+blood -0.529815093 0 0 serum_fattyacid serum_ARA 0.0463 0.697 up no dn no no no 20:0-LPC+blood 5-HETE+blood 0 -0.49980696 0 serum_phospholipids serum_ARA 0.199 0.697 no no no no no no 20:0-LPE+blood 5-HETE+blood -0.670948173 0 0 serum_phospholipids serum_ARA 0.0615 0.697 no no up no no no 20:1+blood 5-HETE+blood 0 0 -0.40240374 yes serum_fattyacid serum_ARA 2.56E-05 0.697 dn dn dn no no no 20:3-LPC+blood 5-HETE+blood -0.513965924 0 0 serum_phospholipids serum_ARA 0.0292 0.697 no up no no no no 20:3-LPE+blood 5-HETE+blood -0.593211771 0 0 serum_phospholipids serum_ARA 0.084 0.697 no up no no no no 20:3n6+blood 5-HETE+blood -0.68604262 0 0 serum_fattyacid serum_ARA 0.0884 0.697 up no no no no no 20:5-LPC+blood 5-HETE+blood 0 0 0.54580081 serum_phospholipids serum_ARA 0.558 0.697 no no no no no no 20:5/18:0-PC+blood 5-HETE+blood 0.450569246 0 0 serum_phospholipids serum_ARA 3.97E-06 0.697 no up up no no no 20:5n3+blood 5-HETE+blood 0 0 0.639111822 serum_fattyacid serum_ARA 0.988 0.697 no no no no no no 22:0/16:0-PE+blood 5-HETE+blood 0.548683152 0 0 serum_phospholipids serum_ARA 0.091 0.697 no no up no no no 14:0/18:2-PC+blood 5-Hydroxyindole-3-acetic Acid+urine 0 -0.554945055 0 serum_phospholipids urine_cometabolism 0.102 0.0405 no up no no dn dn 14:0/20:4-PC+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.503896104 serum_phospholipids urine_cometabolism 0.486 0.0405 no no no no dn dn 16:0/18:0-PC+blood 5-Hydroxyindole-3-acetic Acid+urine 0 -0.615384615 0 serum_phospholipids urine_cometabolism 0.521 0.0405 no no no no dn dn 16:0/18:0-PS+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0 0.436363636 serum_phospholipids urine_cometabolism 0.377 0.0405 no no no no dn dn 16:0/18:1-PC+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0 0.563636364 serum_phospholipids urine_cometabolism 6.15E-07 0.0405 up up up no dn dn 16:0/18:3-PC+blood 5-Hydroxyindole-3-acetic Acid+urine 0 -0.598901099 0 serum_phospholipids urine_cometabolism 0.00216 0.0405 no up up no dn dn 18:0-LPC+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.453246753 serum_phospholipids urine_cometabolism 0.554 0.0405 no no no no dn dn 18:0/16:0-PC+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0 0.602597403 serum_phospholipids urine_cometabolism 9.64E-07 0.0405 up up up no dn dn 18:1/18:2-PI+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.698701299 serum_phospholipids urine_cometabolism 0.0164 0.0405 dn no up no dn dn 18:1/20:3-PC+blood 5-Hydroxyindole-3-acetic Acid+urine -0.612745098 0 0 serum_phospholipids urine_cometabolism 0.00872 0.0405 no up up no dn dn 18:2/18:1-PC+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.444155844 serum_phospholipids urine_cometabolism 2.30E-05 0.0405 dn up up no dn dn 18:2/18:2-PC+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.435064935 serum_phospholipids urine_cometabolism 1.98E-05 0.0405 dn up up no dn dn 18:2n6c+blood 5-Hydroxyindole-3-acetic Acid+urine 0 -0.67032967 0 serum_fattyacid urine_cometabolism 0.15 0.0405 no no no no dn dn 18:3/18:2-PC+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.448051948 serum_phospholipids urine_cometabolism 0.0394 0.0405 no no up no dn dn 2-hydroxyhippuric acid+urine 5-Hydroxyindole-3-acetic Acid+urine 0 0 0.500854701 urine_cometabolism urine_cometabolism 0.215 0.0405 no no no no dn dn "3-(3,4-dihydroxyphenyl)propionic acid+urine" 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.467350427 urine_cometabolism urine_cometabolism 0.0125 0.0405 up up no no dn dn 4-Hydroxyphenylacetic acid+urine 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.402393162 urine_cometabolism urine_cometabolism 0.0321 0.0405 up up no no dn dn Adipocytokine signaling pathway 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.496153846 kegg urine_cometabolism NA 0.0405 no no no no dn dn Adrenergic signaling in cardiomyocytes 5-Hydroxyindole-3-acetic Acid+urine 0 0.459649123 0 kegg urine_cometabolism NA 0.0405 no no up no dn dn Akkermansia 5-Hydroxyindole-3-acetic Acid+urine 0 0.554495937 0 acetate-producing Genus urine_cometabolism 0.23 0.0405 no no no no dn dn Aldosterone synthesis and secretion 5-Hydroxyindole-3-acetic Acid+urine 0 0.507017544 0 kegg urine_cometabolism NA 0.0405 no up up no dn dn AMPK signaling pathway 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.446153846 kegg urine_cometabolism NA 0.0405 no no no no dn dn Apelin signaling pathway 5-Hydroxyindole-3-acetic Acid+urine -0.566666667 0 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Arachidonic acid metabolism 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.449230769 kegg urine_cometabolism NA 0.0405 no no no no dn dn Arginine and proline metabolism 5-Hydroxyindole-3-acetic Acid+urine 0 -0.501754386 0 kegg urine_cometabolism NA 0.0405 no up no no dn dn Axon guidance 5-Hydroxyindole-3-acetic Acid+urine -0.603508772 0 0 kegg urine_cometabolism NA 0.0405 no up up no dn dn Biosynthesis of amino acids 5-Hydroxyindole-3-acetic Acid+urine 0 -0.498245614 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Biosynthesis of cofactors 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.518461538 kegg urine_cometabolism NA 0.0405 no no no no dn dn Calcium signaling pathway 5-Hydroxyindole-3-acetic Acid+urine -0.58245614 0.501754386 0 kegg urine_cometabolism NA 0.0405 no up up no dn dn cGMP-PKG signaling pathway 5-Hydroxyindole-3-acetic Acid+urine 0 -0.473684211 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Coronavirus disease - COVID-19 5-Hydroxyindole-3-acetic Acid+urine -0.519298246 0 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Dilated cardiomyopathy 5-Hydroxyindole-3-acetic Acid+urine 0 0.456140351 0 kegg urine_cometabolism NA 0.0405 no up up no dn dn EGFR tyrosine kinase inhibitor resistance 5-Hydroxyindole-3-acetic Acid+urine -0.561403509 0 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Endocrine and other factor-regulated calcium reabsorption 5-Hydroxyindole-3-acetic Acid+urine 0 0.50877193 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn EPA+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0 0.474025974 serum_ARA urine_cometabolism 0.212 0.0405 no no no no dn dn GABAergic synapse 5-Hydroxyindole-3-acetic Acid+urine 0 -0.487719298 0 kegg urine_cometabolism NA 0.0405 no up up no dn dn Gap junction 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.463846154 kegg urine_cometabolism NA 0.0405 no no no no dn dn Gastric acid secretion 5-Hydroxyindole-3-acetic Acid+urine 0 0.464912281 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Gastric cancer 5-Hydroxyindole-3-acetic Acid+urine -0.487719298 0 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Glioma 5-Hydroxyindole-3-acetic Acid+urine 0 0 0.408461538 kegg urine_cometabolism NA 0.0405 no no no no dn dn Glutamatergic synapse 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.408461538 kegg urine_cometabolism NA 0.0405 no up up no dn dn Glutathione metabolism 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.474615385 kegg urine_cometabolism NA 0.0405 no no no no dn dn "Glycine, serine and threonine metabolism" 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.537692308 kegg urine_cometabolism NA 0.0405 no up no no dn dn HIF-1 signaling pathway 5-Hydroxyindole-3-acetic Acid+urine -0.575438596 0 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Hippo signaling pathway 5-Hydroxyindole-3-acetic Acid+urine 0 0.470175439 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Hypotaurine+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0 0.474025974 serum_aminoacids urine_cometabolism 0.933 0.0405 no no no no dn dn Inflammatory mediator regulation of TRP channels 5-Hydroxyindole-3-acetic Acid+urine 0 0.496491228 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Insulin secretion 5-Hydroxyindole-3-acetic Acid+urine 0 0.468421053 0 yes kegg urine_cometabolism NA 0.0405 no up up no dn dn Insulin signaling pathway 5-Hydroxyindole-3-acetic Acid+urine -0.543859649 0 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Kaposi sarcoma-associated herpesvirus infection 5-Hydroxyindole-3-acetic Acid+urine -0.459649123 0 0 kegg urine_cometabolism NA 0.0405 no no dn no dn dn L-Isoleucine+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0.582417582 0 yes serum_aminoacids urine_cometabolism 5.47E-06 0.0405 up up no no dn dn L-Methionine+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0.565934066 0.512987013 serum_aminoacids urine_cometabolism 0.626 0.0405 no no no no dn dn L-Tryptophan+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0.642857143 0 serum_aminoacids urine_cometabolism 0.164 0.0405 no no no no dn dn LCA+stool 5-Hydroxyindole-3-acetic Acid+urine 0.591208791 0 0 stool_bileacids urine_cometabolism 0.314 0.0405 no no no no dn dn Long-term depression 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.440769231 kegg urine_cometabolism NA 0.0405 no no no no dn dn Longevity regulating pathway 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.44 kegg urine_cometabolism NA 0.0405 no no no no dn dn Malaria 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.468461538 kegg urine_cometabolism NA 0.0405 no no no no dn dn Melanogenesis 5-Hydroxyindole-3-acetic Acid+urine 0 0.633333333 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Mitophagy - animal 5-Hydroxyindole-3-acetic Acid+urine -0.463157895 0 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn mRNA surveillance pathway 5-Hydroxyindole-3-acetic Acid+urine 0 0.494736842 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn mTOR signaling pathway 5-Hydroxyindole-3-acetic Acid+urine -0.575438596 0 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn MUFA%+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0 0.494805195 serum_fattyacid urine_cometabolism 0.00142 0.0405 up no dn no dn dn n6+blood 5-Hydroxyindole-3-acetic Acid+urine 0 -0.60989011 0 serum_fattyacid urine_cometabolism 0.153 0.0405 no no no no dn dn nutriCA+blood 5-Hydroxyindole-3-acetic Acid+urine -0.648142091 0 0 serum_bileacids urine_cometabolism 0.726 0.0405 no no no no dn dn Pancreatic cancer 5-Hydroxyindole-3-acetic Acid+urine -0.498245614 0 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Pancreatic secretion 5-Hydroxyindole-3-acetic Acid+urine 0 0.60877193 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Pathways of neurodegeneration - multiple diseases 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.406923077 kegg urine_cometabolism NA 0.0405 no no no no dn dn Peroxisome 5-Hydroxyindole-3-acetic Acid+urine 0 -0.471929825 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Porphyrin and chlorophyll metabolism 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.539230769 kegg urine_cometabolism NA 0.0405 no no no no dn dn PPAR signaling pathway 5-Hydroxyindole-3-acetic Acid+urine 0 -0.489473684 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Proteasome 5-Hydroxyindole-3-acetic Acid+urine 0 0 0.436153846 kegg urine_cometabolism NA 0.0405 no no no no dn dn Proteoglycans in cancer 5-Hydroxyindole-3-acetic Acid+urine 0 0 0.453846154 kegg urine_cometabolism NA 0.0405 no no no no dn dn Ras signaling pathway 5-Hydroxyindole-3-acetic Acid+urine -0.649122807 0 0 yes kegg urine_cometabolism NA 0.0405 no up up no dn dn Renal cell carcinoma 5-Hydroxyindole-3-acetic Acid+urine -0.605263158 0 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Renin secretion 5-Hydroxyindole-3-acetic Acid+urine 0 0.473684211 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Ribosome 5-Hydroxyindole-3-acetic Acid+urine -0.519298246 0 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn RNA degradation 5-Hydroxyindole-3-acetic Acid+urine 0 0.505263158 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Sphingolipid signaling pathway 5-Hydroxyindole-3-acetic Acid+urine 0 0 0.463846154 kegg urine_cometabolism NA 0.0405 no no no no dn dn TGF-beta signaling pathway 5-Hydroxyindole-3-acetic Acid+urine -0.522807018 0 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Th1 and Th2 cell differentiation 5-Hydroxyindole-3-acetic Acid+urine 0 0 0.496153846 kegg urine_cometabolism NA 0.0405 no no no no dn dn Th17 cell differentiation 5-Hydroxyindole-3-acetic Acid+urine 0 0 0.472307692 kegg urine_cometabolism NA 0.0405 no no no no dn dn Thyroid hormone signaling pathway 5-Hydroxyindole-3-acetic Acid+urine 0 0.489473684 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Thyroid hormone synthesis 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.571538462 kegg urine_cometabolism NA 0.0405 no no no no dn dn Toxoplasmosis 5-Hydroxyindole-3-acetic Acid+urine 0.7 0 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn TXB2+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.475943185 yes serum_ARA urine_cometabolism 0.0644 0.0405 dn no no no dn dn Valine+blood 5-Hydroxyindole-3-acetic Acid+urine 0 0.637362637 0 yes serum_aminoacids urine_cometabolism 1.22E-06 0.0405 up up no no dn dn Vascular smooth muscle contraction 5-Hydroxyindole-3-acetic Acid+urine -0.538596491 0 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn Wnt signaling pathway 5-Hydroxyindole-3-acetic Acid+urine -0.503508772 0.536842105 0 kegg urine_cometabolism NA 0.0405 no no no no dn dn 2-hydroxyhippuric acid+urine 5-Hydroxytryptamine+urine 0 0 -0.412649573 urine_cometabolism urine_cometabolism 0.215 0.171 no no no no no no 3-Hydroxytyramine hydrochloride+urine 5-Hydroxytryptamine+urine 0.566917293 0.610526316 0.688205128 urine_cometabolism urine_cometabolism 0.288 0.171 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine 5-Hydroxytryptamine+urine 0.454135338 0 0 urine_cometabolism urine_cometabolism 0.973 0.171 no no no no no no 11-HETE+blood 8-HETE+blood 0 0 -0.517370787 serum_ARA serum_ARA 0.464 0.741 no no no no no no 12-HEPE+blood 8-HETE+blood -0.614407251 0 0 serum_ARA serum_ARA 0.312 0.741 no no no no no no 12-ketoDCA+blood 8-HETE+blood 0 0 -0.443288121 serum_bileacids serum_ARA 0.517 0.741 no no no no no no 13-HODE+blood 8-HETE+blood 0 0.659313725 0.548717949 serum_ARA serum_ARA 0.32 0.741 no no no no no no 14:0/16:0-PC+blood 8-HETE+blood 0 -0.536764706 0 serum_phospholipids serum_ARA 0.0358 0.741 no up no no no no 16:0/16:1-PC+blood 8-HETE+blood 0 -0.522058824 0 serum_phospholipids serum_ARA 0.00283 0.741 up up no no no no 16:0/16:1-PI+blood 8-HETE+blood 0 -0.598039216 0 serum_phospholipids serum_ARA 0.262 0.741 no no no no no no 16:0/20:4-PI+blood 8-HETE+blood 0 -0.573529412 0 serum_phospholipids serum_ARA 0.558 0.741 no no no no no no 18:0-LPC+blood 8-HETE+blood 0 -0.549019608 0 serum_phospholipids serum_ARA 0.554 0.741 no no no no no no 18:0-LPE+blood 8-HETE+blood 0 -0.487745098 0 serum_phospholipids serum_ARA 0.491 0.741 no no no no no no 18:0/18:0-PS+blood 8-HETE+blood 0 -0.607843137 0 serum_phospholipids serum_ARA 0.00617 0.741 no up no no no no 18:0/18:1-PG+blood 8-HETE+blood 0 -0.541666667 0 serum_phospholipids serum_ARA 0.000842 0.741 no up no no no no 18:0/20:3-PC+blood 8-HETE+blood 0 -0.524509804 0 serum_phospholipids serum_ARA 0.0682 0.741 no up no no no no 18:1/16:0-PC+blood 8-HETE+blood 0 0.50245098 0 serum_phospholipids serum_ARA 2.43E-05 0.741 no up up no no no 18:1/18:1-PG+blood 8-HETE+blood 0 -0.639705882 0 serum_phospholipids serum_ARA 0.00352 0.741 no up up no no no 18:1/20:4-PE+blood 8-HETE+blood 0.603007519 0 0 serum_phospholipids serum_ARA 0.0578 0.741 up no no no no no 18:2/16:0-PC+blood 8-HETE+blood 0 0.524509804 0 serum_phospholipids serum_ARA 8.67E-05 0.741 no up up no no no 18:3n6+blood 8-HETE+blood 0 -0.681372549 0 serum_fattyacid serum_ARA 0.0463 0.741 up no dn no no no 20-HDOHE+blood 8-HETE+blood 0 0 -0.462250164 serum_ARA serum_ARA 0.205 0.741 no no no no no no 20:0-LPC+blood 8-HETE+blood 0 0 0.515213675 serum_phospholipids serum_ARA 0.199 0.741 no no no no no no 20:0/20:4-PE+blood 8-HETE+blood 0 -0.56127451 0 serum_phospholipids serum_ARA 0.00128 0.741 up up no no no no 20:1/20:4-PE+blood 8-HETE+blood 0.578947368 -0.482843137 0 serum_phospholipids serum_ARA 0.0042 0.741 up up no no no no 20:2/18:0-PC+blood 8-HETE+blood 0 -0.529411765 0 serum_phospholipids serum_ARA 0.0427 0.741 no up no no no no 20:2/18:1-PE+blood 8-HETE+blood 0 -0.529411765 0 serum_phospholipids serum_ARA 0.00208 0.741 up up no no no no 20:3n6+blood 8-HETE+blood 0 -0.49754902 0 serum_fattyacid serum_ARA 0.0884 0.741 up no no no no no 20:4/18:0-PE+blood 8-HETE+blood 0.452631579 0 0 serum_phospholipids serum_ARA 0.000755 0.741 up up no no no no 24:0+blood 8-HETE+blood 0.560902256 0 0 serum_fattyacid serum_ARA 0.034 0.741 dn no up no no no Adherens junction 8-HETE+blood 0 0 -0.552307692 kegg serum_ARA NA 0.741 no no no no no no AGE-RAGE signaling pathway in diabetic complications 8-HETE+blood 0 0 0.433076923 kegg serum_ARA NA 0.741 no no no no no no Alcoholism 8-HETE+blood 0 0 -0.482307692 kegg serum_ARA NA 0.741 no no no no no no Antigen processing and presentation 8-HETE+blood 0 0 -0.420769231 kegg serum_ARA NA 0.741 no no no no no no Arrhythmogenic right ventricular cardiomyopathy 8-HETE+blood 0 0 -0.543076923 kegg serum_ARA NA 0.741 no up up no no no Autophagy - animal 8-HETE+blood 0 0 0.562307692 kegg serum_ARA NA 0.741 no no no no no no Bacterial invasion of epithelial cells 8-HETE+blood 0 0 -0.625384615 kegg serum_ARA NA 0.741 no no no no no no Bacteroides 8-HETE+blood 0 0 -0.435213675 LPS-producing Genus serum_ARA 0.000267 0.741 dn dn up no no no Breast cancer 8-HETE+blood 0 0 0.594615385 kegg serum_ARA NA 0.741 no no no no no no Butyric acid+stool 8-HETE+blood 0 0 0.502255639 yes stool_scfa serum_ARA 0.102 0.741 dn no no no no no Chemokine signaling pathway 8-HETE+blood 0 0.5 -0.453076923 kegg serum_ARA NA 0.741 no no no no no no Choline metabolism in cancer 8-HETE+blood 0 0 0.542307692 kegg serum_ARA NA 0.741 no no no no no no Chronic myeloid leukemia 8-HETE+blood 0 0 0.492307692 kegg serum_ARA NA 0.741 no no no no no no Circadian entrainment 8-HETE+blood 0 0 -0.494615385 kegg serum_ARA NA 0.741 no up up no no no Colorectal cancer 8-HETE+blood 0 0 0.409230769 kegg serum_ARA NA 0.741 no no no no no no Cytokine-cytokine receptor interaction 8-HETE+blood 0 0 -0.602307692 kegg serum_ARA NA 0.741 no no no no no no DCA+stool 8-HETE+blood -0.593406593 0 0 stool_bileacids serum_ARA 0.195 0.741 no no no no no no Dilated cardiomyopathy 8-HETE+blood 0 0 -0.476153846 kegg serum_ARA NA 0.741 no up up no no no Endocytosis 8-HETE+blood 0.503508772 0 0 kegg serum_ARA NA 0.741 no no no no no no ErbB signaling pathway 8-HETE+blood 0 0 0.471538462 kegg serum_ARA NA 0.741 no no no no no no Fc gamma R-mediated phagocytosis 8-HETE+blood 0.507017544 0 0 kegg serum_ARA NA 0.741 no no no no no no Fluid shear stress and atherosclerosis 8-HETE+blood 0 0 -0.498461538 kegg serum_ARA NA 0.741 no no no no no no Focal adhesion 8-HETE+blood 0 0 -0.502307692 kegg serum_ARA NA 0.741 no up up no no no Gap junction 8-HETE+blood 0 0 -0.41 kegg serum_ARA NA 0.741 no no no no no no Gastric acid secretion 8-HETE+blood 0 0 -0.532307692 kegg serum_ARA NA 0.741 no no no no no no Gastric cancer 8-HETE+blood 0 0 0.503076923 kegg serum_ARA NA 0.741 no no no no no no Hepatitis B 8-HETE+blood 0 0 0.522307692 kegg serum_ARA NA 0.741 no no no no no no Hippo signaling pathway 8-HETE+blood 0 0 -0.431538462 kegg serum_ARA NA 0.741 no no no no no no Hypertrophic cardiomyopathy 8-HETE+blood 0 0 -0.554615385 kegg serum_ARA NA 0.741 no up up no no no Insulin resistance 8-HETE+blood 0 0 0.601538462 kegg serum_ARA NA 0.741 no no no no no no L-Phenylalanine+stool 8-HETE+blood 0 0.718181818 0 stool_cometabolism serum_ARA 0.398 0.741 no no no no no no L-Tryptophan+stool 8-HETE+blood 0 0.845454545 0 stool_cometabolism serum_ARA 0.557 0.741 no no no no no no L-Tyrosine+stool 8-HETE+blood 0.571428571 0 0 stool_cometabolism serum_ARA 0.44 0.741 no no no no no no Lachnospira 8-HETE+blood 0 0 0.531850095 butyrate-producing Genus serum_ARA 0.279 0.741 no no no no no no Leukocyte transendothelial migration 8-HETE+blood 0 0 -0.613076923 kegg serum_ARA NA 0.741 no no no no no no MicroRNAs in cancer 8-HETE+blood 0 0 0.534615385 kegg serum_ARA NA 0.741 no no no no no no Mitophagy - animal 8-HETE+blood -0.485964912 0 0 kegg serum_ARA NA 0.741 no no no no no no Natural killer cell mediated cytotoxicity 8-HETE+blood 0.471929825 0 0 kegg serum_ARA NA 0.741 no no no no no no Neutrophil extracellular trap formation 8-HETE+blood 0 0 -0.423846154 kegg serum_ARA NA 0.741 no no no no no no NF-kappa B signaling pathway 8-HETE+blood 0 0 0.525384615 kegg serum_ARA NA 0.741 no no no no no no Non-small cell lung cancer 8-HETE+blood 0 0 0.424615385 kegg serum_ARA NA 0.741 no no no no no no Olfactory transduction 8-HETE+blood 0.463157895 0 0 kegg serum_ARA NA 0.741 no no no no no no Oocyte meiosis 8-HETE+blood 0 -0.511764706 0 kegg serum_ARA NA 0.741 no no no no no no Oxytocin signaling pathway 8-HETE+blood 0.524561404 0 -0.553076923 kegg serum_ARA NA 0.741 no no no no no no p53 signaling pathway 8-HETE+blood 0 0 0.506153846 kegg serum_ARA NA 0.741 no no no no no no Pancreatic cancer 8-HETE+blood 0 0 0.419230769 kegg serum_ARA NA 0.741 no no no no no no Paraprevotella 8-HETE+blood 0.485422563 0 0 Genus serum_ARA 0.118 0.741 no no no no no no Pathogenic Escherichia coli infection 8-HETE+blood 0.631578947 0.5 -0.456923077 kegg serum_ARA NA 0.741 no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer 8-HETE+blood 0 0 0.493076923 kegg serum_ARA NA 0.741 no no no no no no Phosphatidylinositol signaling system 8-HETE+blood 0 0 0.461538462 kegg serum_ARA NA 0.741 no no no no no no Platelet activation 8-HETE+blood 0 0 -0.528461538 kegg serum_ARA NA 0.741 no no no no no no Platinum drug resistance 8-HETE+blood 0 0 0.426923077 kegg serum_ARA NA 0.741 no no no no no no Prostate cancer 8-HETE+blood 0 0.517647059 0.416923077 kegg serum_ARA NA 0.741 no no no no no no Rap1 signaling pathway 8-HETE+blood 0 0 -0.515384615 kegg serum_ARA NA 0.741 no no no no no no Regulation of actin cytoskeleton 8-HETE+blood 0 0 -0.647692308 kegg serum_ARA NA 0.741 no no no no no no Renin secretion 8-HETE+blood 0 0 -0.414615385 kegg serum_ARA NA 0.741 no no no no no no Salivary secretion 8-HETE+blood 0 0 -0.413846154 kegg serum_ARA NA 0.741 no no no no no no Salmonella infection 8-HETE+blood 0.628070175 0 -0.535384615 kegg serum_ARA NA 0.741 no no no no no no Signaling pathways regulating pluripotency of stem cells 8-HETE+blood 0 0 0.53 kegg serum_ARA NA 0.741 no no no no no no Small cell lung cancer 8-HETE+blood 0 0 0.423846154 kegg serum_ARA NA 0.741 no no up no no no Thermogenesis 8-HETE+blood 0 0 -0.407692308 kegg serum_ARA NA 0.741 no no no no no no Tight junction 8-HETE+blood 0 0 -0.51 kegg serum_ARA NA 0.741 no no no no no no TNF signaling pathway 8-HETE+blood 0 0.532352941 0 kegg serum_ARA NA 0.741 no no no no no no Transcriptional misregulation in cancer 8-HETE+blood 0 0 0.542307692 kegg serum_ARA NA 0.741 no no no no no no Vasopressin-regulated water reabsorption 8-HETE+blood 0 0 -0.430769231 kegg serum_ARA NA 0.741 no no no no no no Vibrio cholerae infection 8-HETE+blood 0 0 -0.53 kegg serum_ARA NA 0.741 no no no no no no Viral protein interaction with cytokine and cytokine receptor 8-HETE+blood 0 0 -0.704615385 kegg serum_ARA NA 0.741 no no no no no no Yersinia infection 8-HETE+blood 0.592982456 0 -0.526923077 kegg serum_ARA NA 0.741 no no no no no no 11-HETE+blood 9-HODE+blood 0 0 -0.419130731 serum_ARA serum_ARA 0.464 0.297 no no no no no no 12-HEPE+blood 9-HODE+blood 0 0 -0.48143311 serum_ARA serum_ARA 0.312 0.297 no no no no no no "12,13-EPOME+blood" 9-HODE+blood 0.57229258 0 0 serum_ARA serum_ARA 0.901 0.297 no no no no no no 13-HODE+blood 9-HODE+blood 0 0.703431373 0 serum_ARA serum_ARA 0.32 0.297 no no no no no no 18:0-LPC+blood 9-HODE+blood 0 -0.553921569 0 serum_phospholipids serum_ARA 0.554 0.297 no no no no no no 18:0/18:0-PC+blood 9-HODE+blood -0.464661654 0 0 serum_phospholipids serum_ARA 0.426 0.297 no no no no no no 18:0/18:0-PS+blood 9-HODE+blood 0 -0.553921569 0 serum_phospholipids serum_ARA 0.00617 0.297 no up no no no no 18:0/18:1-PG+blood 9-HODE+blood 0 -0.737745098 0 serum_phospholipids serum_ARA 0.000842 0.297 no up no no no no 18:0+blood 9-HODE+blood 0 -0.573529412 0 serum_fattyacid serum_ARA 0.344 0.297 no no no no no no 18:1/18:2-PI+blood 9-HODE+blood 0.609022556 0 0 serum_phospholipids serum_ARA 0.0164 0.297 dn no up no no no 18:2-LPA+blood 9-HODE+blood 0 0.5 0 serum_phospholipids serum_ARA 0.00684 0.297 dn no up no no no 18:2-LPC+blood 9-HODE+blood 0 0.56372549 0 serum_phospholipids serum_ARA 0.00743 0.297 dn no up no no no 18:2-LPE+blood 9-HODE+blood 0 0 0.423589744 serum_phospholipids serum_ARA 0.112 0.297 no no no no no no 18:3n6+blood 9-HODE+blood 0 -0.666666667 0 serum_fattyacid serum_ARA 0.0463 0.297 up no dn no no no 20:1/20:4-PE+blood 9-HODE+blood 0 -0.50245098 0 serum_phospholipids serum_ARA 0.0042 0.297 up up no no no no 20:2-LPC+blood 9-HODE+blood 0.50075188 0 0 serum_phospholipids serum_ARA 0.119 0.297 no no up no no no 20:2-LPE+blood 9-HODE+blood 0 0 0.432478632 serum_phospholipids serum_ARA 0.177 0.297 no no no no no no 20:2/18:1-PE+blood 9-HODE+blood 0 -0.490196078 0 serum_phospholipids serum_ARA 0.00208 0.297 up up no no no no 20:3/18:0-PI+blood 9-HODE+blood 0 -0.482843137 0 serum_phospholipids serum_ARA 0.289 0.297 no no no no no no Adherens junction 9-HODE+blood 0 0 -0.449230769 kegg serum_ARA NA 0.297 no no no no no no Alistipes 9-HODE+blood -0.502645088 0 0 Genus serum_ARA 0.0114 0.297 no up no no no no Autophagy - animal 9-HODE+blood 0 0 0.412307692 kegg serum_ARA NA 0.297 no no no no no no Axon guidance 9-HODE+blood 0 0 0.430769231 kegg serum_ARA NA 0.297 no up up no no no Central carbon metabolism in cancer 9-HODE+blood 0 -0.611764706 0 kegg serum_ARA NA 0.297 no no no no no no Clostridium 9-HODE+blood 0 -0.501532896 0 Genus serum_ARA 0.925 0.297 no no no no no no Fluid shear stress and atherosclerosis 9-HODE+blood 0 0 -0.459230769 kegg serum_ARA NA 0.297 no no no no no no Gastric acid secretion 9-HODE+blood 0 0 -0.45 kegg serum_ARA NA 0.297 no no no no no no GCDCA+stool 9-HODE+blood -0.56043956 0 0 yes stool_bileacids serum_ARA 0.0471 0.297 no dn no no no no L-Phenylalanine+stool 9-HODE+blood 0 0.645454545 0 stool_cometabolism serum_ARA 0.398 0.297 no no no no no no L-Tryptophan+stool 9-HODE+blood 0 0.618181818 0 stool_cometabolism serum_ARA 0.557 0.297 no no no no no no L-Tyrosine+stool 9-HODE+blood 0 0.8 0 stool_cometabolism serum_ARA 0.44 0.297 no no no no no no Neutrophil extracellular trap formation 9-HODE+blood 0 0 -0.415384615 kegg serum_ARA NA 0.297 no no no no no no nutriCA+stool 9-HODE+blood 0 -0.853246918 0 stool_bileacids serum_ARA 0.481 0.297 no no no no no no Oscillospira 9-HODE+blood -0.527819549 0 0 LPS-producing Genus serum_ARA 0.62 0.297 no no no no no no Oxytocin signaling pathway 9-HODE+blood 0 0 -0.413076923 kegg serum_ARA NA 0.297 no no no no no no Pancreatic cancer 9-HODE+blood 0 0 0.409230769 kegg serum_ARA NA 0.297 no no no no no no Parabacteroides 9-HODE+blood -0.65112782 0 0 Genus serum_ARA 4.19E-05 0.297 no up up no no no Ruminococcus 9-HODE+blood 0.484862399 0 0 Genus serum_ARA 0.0679 0.297 no no dn no no no Signaling pathways regulating pluripotency of stem cells 9-HODE+blood 0 0 0.430769231 kegg serum_ARA NA 0.297 no no no no no no Spliceosome 9-HODE+blood 0 0 0.410769231 kegg serum_ARA NA 0.297 no no no no no no Systemic lupus erythematosus 9-HODE+blood 0 0 -0.507692308 kegg serum_ARA NA 0.297 no no no no no no T cell receptor signaling pathway 9-HODE+blood 0 0 0.588461538 kegg serum_ARA NA 0.297 no no no no no no Tight junction 9-HODE+blood 0 0 -0.561538462 kegg serum_ARA NA 0.297 no no no no no no Transcriptional misregulation in cancer 9-HODE+blood 0 0 0.443076923 kegg serum_ARA NA 0.297 no no no no no no TUDCA+stool 9-HODE+blood 0 0.610695507 0 stool_bileacids serum_ARA 0.241 0.297 no no no no no no Vibrio cholerae infection 9-HODE+blood 0 0 -0.443846154 kegg serum_ARA NA 0.297 no no no no no no "12,13-EPOME+blood" "9,10-EPOME+blood" 0.50097146 0.538708416 0.58653442 serum_ARA serum_ARA 0.901 0.801 no no no no no no 14:0-LPC+blood "9,10-EPOME+blood" 0 0 -0.411357408 serum_phospholipids serum_ARA 0.00689 0.801 up up no no no no 14:0/16:0-PC+blood "9,10-EPOME+blood" 0 0 -0.544463861 serum_phospholipids serum_ARA 0.0358 0.801 no up no no no no 14:1/18:2-PG+blood "9,10-EPOME+blood" 0 0 -0.409981631 serum_phospholipids serum_ARA 0.00259 0.801 no up up no no no 16:0/16:0-PI+blood "9,10-EPOME+blood" 0 0 -0.440592676 serum_phospholipids serum_ARA 0.358 0.801 no no no no no no 16:0/18:3-PC+blood "9,10-EPOME+blood" 0 0 -0.45847778 serum_phospholipids serum_ARA 0.00216 0.801 no up up no no no 16:1/16:1-PC+blood "9,10-EPOME+blood" 0 0.486487955 0 serum_phospholipids serum_ARA 0.0177 0.801 no no up no no no 18:0/20:3-PC+blood "9,10-EPOME+blood" 0 0 -0.413765019 serum_phospholipids serum_ARA 0.0682 0.801 no up no no no no 18:0/22:6-PE+blood "9,10-EPOME+blood" 0 0.515972073 0 serum_phospholipids serum_ARA 0.00022 0.801 up up no no no no 18:2/18:2-PS+blood "9,10-EPOME+blood" -0.600753374 0 0 serum_phospholipids serum_ARA 0.00674 0.801 up up no no no no 20:2/18:0-PC+blood "9,10-EPOME+blood" 0 0 -0.480490217 serum_phospholipids serum_ARA 0.0427 0.801 no up no no no no 20:2/18:1-PE+blood "9,10-EPOME+blood" -0.459399639 0 0 serum_phospholipids serum_ARA 0.00208 0.801 up up no no no no 20:3-LPC+blood "9,10-EPOME+blood" 0 0 -0.451598894 serum_phospholipids serum_ARA 0.0292 0.801 no up no no no no 24:0+blood "9,10-EPOME+blood" 0 0 -0.515916482 serum_fattyacid serum_ARA 0.034 0.801 dn no up no no no ACA+stool "9,10-EPOME+blood" 0 0 -0.622508781 stool_bileacids serum_ARA 0.417 0.801 no no no no no no Adipocytokine signaling pathway "9,10-EPOME+blood" 0 0 -0.442217317 kegg serum_ARA NA 0.801 no no no no no no Alcoholism "9,10-EPOME+blood" 0 0.595872799 0 kegg serum_ARA NA 0.801 no no no no no no Axon guidance "9,10-EPOME+blood" 0 0 0.530118657 kegg serum_ARA NA 0.801 no up up no no no Bacteroides "9,10-EPOME+blood" 0 0 -0.404478522 LPS-producing Genus serum_ARA 0.000267 0.801 dn dn up no no no Cell cycle "9,10-EPOME+blood" 0 0 0.422081327 kegg serum_ARA NA 0.801 no no no no no no Central carbon metabolism in cancer "9,10-EPOME+blood" 0 0 0.422468558 kegg serum_ARA NA 0.801 no no no no no no Choline metabolism in cancer "9,10-EPOME+blood" 0 -0.516226435 0.458481001 kegg serum_ARA NA 0.801 no no no no no no Cholinergic synapse "9,10-EPOME+blood" 0 0 0.465063921 kegg serum_ARA NA 0.801 no no no no no no Chronic myeloid leukemia "9,10-EPOME+blood" 0 -0.516226435 0 kegg serum_ARA NA 0.801 no no no no no no Collinsella "9,10-EPOME+blood" 0 0 -0.44209358 Genus serum_ARA 0.128 0.801 no no no no no no Colorectal cancer "9,10-EPOME+blood" 0 -0.681418894 0.519276201 kegg serum_ARA NA 0.801 no no no no no no Cytosolic DNA-sensing pathway "9,10-EPOME+blood" 0 -0.528025896 0 kegg serum_ARA NA 0.801 no no no no no no ErbB signaling pathway "9,10-EPOME+blood" 0 0 0.454995926 kegg serum_ARA NA 0.801 no no no no no no Ferroptosis "9,10-EPOME+blood" 0 0 -0.529344196 kegg serum_ARA NA 0.801 no no no no no no Gastric cancer "9,10-EPOME+blood" 0 -0.589973068 0.404655951 kegg serum_ARA NA 0.801 no no no no no no Glioma "9,10-EPOME+blood" 0 0 0.611437078 kegg serum_ARA NA 0.801 no no no no no no Glutathione metabolism "9,10-EPOME+blood" 0 0 -0.404655951 kegg serum_ARA NA 0.801 no no no no no no Hepatitis C "9,10-EPOME+blood" 0 -0.578173607 0 kegg serum_ARA NA 0.801 no no no no no no Insulin resistance "9,10-EPOME+blood" 0 -0.504426973 0 kegg serum_ARA NA 0.801 no no no no no no Kaposi sarcoma-associated herpesvirus infection "9,10-EPOME+blood" 0 0 -0.449187467 kegg serum_ARA NA 0.801 no no dn no no no LCA+stool "9,10-EPOME+blood" 0.650180406 0 0 stool_bileacids serum_ARA 0.314 0.801 no no no no no no Long-term potentiation "9,10-EPOME+blood" 0 0 0.578135249 kegg serum_ARA NA 0.801 no no up no no no Malaria "9,10-EPOME+blood" 0 0 -0.518888971 kegg serum_ARA NA 0.801 no no no no no no MAPK signaling pathway "9,10-EPOME+blood" 0 0 0.542897266 kegg serum_ARA NA 0.801 no no no no no no Measles "9,10-EPOME+blood" 0 -0.501477108 0 kegg serum_ARA NA 0.801 no no no no no no Mineral absorption "9,10-EPOME+blood" 0 0 -0.482876527 kegg serum_ARA NA 0.801 no no no no no no Mitophagy - animal "9,10-EPOME+blood" 0 0 -0.46467669 kegg serum_ARA NA 0.801 no no no no no no Necroptosis "9,10-EPOME+blood" 0 0 -0.451510851 kegg serum_ARA NA 0.801 no no no no no no nutriCA+stool "9,10-EPOME+blood" -0.612614427 0 0 stool_bileacids serum_ARA 0.481 0.801 no no no no no no Oocyte meiosis "9,10-EPOME+blood" 0 0 0.51850174 kegg serum_ARA NA 0.801 no no no no no no Parkinson disease "9,10-EPOME+blood" 0 0 -0.540573883 kegg serum_ARA NA 0.801 no no no no no no Pathways of neurodegeneration - multiple diseases "9,10-EPOME+blood" 0 0 -0.553739723 kegg serum_ARA NA 0.801 no no no no no no Phosphatidylinositol signaling system "9,10-EPOME+blood" 0 0 0.4913956 kegg serum_ARA NA 0.801 no no no no no no Porphyrin and chlorophyll metabolism "9,10-EPOME+blood" 0 0 -0.422081327 kegg serum_ARA NA 0.801 no no no no no no Progesterone-mediated oocyte maturation "9,10-EPOME+blood" 0 0 0.405430412 kegg serum_ARA NA 0.801 no no no no no no Proteoglycans in cancer "9,10-EPOME+blood" 0 0 0.401558106 kegg serum_ARA NA 0.801 no no no no no no Purine metabolism "9,10-EPOME+blood" 0 0 -0.449961928 kegg serum_ARA NA 0.801 no no no no no no Renal cell carcinoma "9,10-EPOME+blood" 0 0 0.477068069 kegg serum_ARA NA 0.801 no no no no no no RNA degradation "9,10-EPOME+blood" 0 0 0.44415347 kegg serum_ARA NA 0.801 no no no no no no RNA transport "9,10-EPOME+blood" 0 0 0.439893933 kegg serum_ARA NA 0.801 no no no no no no Shigellosis "9,10-EPOME+blood" 0 0 -0.495655136 kegg serum_ARA NA 0.801 no no no no no no Signaling pathways regulating pluripotency of stem cells "9,10-EPOME+blood" 0 -0.587023203 0.400009184 kegg serum_ARA NA 0.801 no no no no no no Small cell lung cancer "9,10-EPOME+blood" 0 -0.530975762 0 kegg serum_ARA NA 0.801 no no up no no no Spinocerebellar ataxia "9,10-EPOME+blood" 0 0 0.436021628 kegg serum_ARA NA 0.801 no no no no no no Spliceosome "9,10-EPOME+blood" 0 0 0.450349159 kegg serum_ARA NA 0.801 no no no no no no T cell receptor signaling pathway "9,10-EPOME+blood" 0 -0.581123472 0.577360788 kegg serum_ARA NA 0.801 no no no no no no Th1 and Th2 cell differentiation "9,10-EPOME+blood" 0 -0.660769837 0 kegg serum_ARA NA 0.801 no no no no no no Th17 cell differentiation "9,10-EPOME+blood" 0 -0.705017817 0 kegg serum_ARA NA 0.801 no no no no no no Ubiquitin mediated proteolysis "9,10-EPOME+blood" 0 0 -0.455770387 kegg serum_ARA NA 0.801 no no no no no no 12-HEPE+blood AA+blood -0.476528458 0 0 serum_ARA serum_ARA 0.312 0.212 no no no no no no 12-ketoDCA+blood AA+blood -0.466774616 0 0 serum_bileacids serum_ARA 0.517 0.212 no no no no no no 13-HODE+blood AA+blood 0.655639098 0 0 serum_ARA serum_ARA 0.32 0.212 no no no no no no 14:0/18:0-PC+blood AA+blood 0 -0.62254902 0 serum_phospholipids serum_ARA 0.00289 0.212 up up no no no no 16:0-LPC+blood AA+blood 0.581954887 0 0 serum_phospholipids serum_ARA 0.00456 0.212 up up no no no no 16:0/16:1-PC+blood AA+blood 0 -0.620098039 0 serum_phospholipids serum_ARA 0.00283 0.212 up up no no no no 16:0/16:1-PI+blood AA+blood 0 -0.678921569 0 serum_phospholipids serum_ARA 0.262 0.212 no no no no no no 16:0/18:1-PE+blood AA+blood 0 -0.504901961 0 serum_phospholipids serum_ARA 0.000107 0.212 up up no no no no 16:0/18:2-PI+blood AA+blood 0 -0.727941176 0 serum_phospholipids serum_ARA 0.269 0.212 no no no no no no 16:0/20:4-PC+blood AA+blood 0 0.531862745 0 serum_phospholipids serum_ARA 0.0262 0.212 no up no no no no 16:0/20:4-PI+blood AA+blood 0 -0.541666667 0 serum_phospholipids serum_ARA 0.558 0.212 no no no no no no 16:0+blood AA+blood 0.494736842 0 0 yes serum_fattyacid serum_ARA 0.00876 0.212 up no no no no no 16:1/16:0-PC+blood AA+blood 0.463157895 0 0 serum_phospholipids serum_ARA 0.0215 0.212 no up up no no no 16:1/16:1-PC+blood AA+blood 0.472180451 0 0 serum_phospholipids serum_ARA 0.0177 0.212 no no up no no no 16:1/18:2-PG+blood AA+blood 0.568421053 0 0 serum_phospholipids serum_ARA 1.40E-08 0.212 no up up no no no 16:1+blood AA+blood 0.612030075 0 0 yes serum_fattyacid serum_ARA 0.0186 0.212 no no dn no no no 18:0-LPC+blood AA+blood 0 -0.482843137 0 serum_phospholipids serum_ARA 0.554 0.212 no no no no no no 18:0/18:0-PC+blood AA+blood 0 -0.659313725 0 serum_phospholipids serum_ARA 0.426 0.212 no no no no no no 18:0/18:1-PC+blood AA+blood 0 -0.703431373 0 serum_phospholipids serum_ARA 0.393 0.212 no no no no no no 18:0/20:2-PC+blood AA+blood -0.494736842 -0.683823529 0 serum_phospholipids serum_ARA 0.733 0.212 no no no no no no 18:0/20:3-PC+blood AA+blood 0 -0.776960784 0 serum_phospholipids serum_ARA 0.0682 0.212 no up no no no no 18:0/20:5-PC+blood AA+blood 0 0.578431373 0.543931624 serum_phospholipids serum_ARA 0.17 0.212 no no no no no no 18:1/16:1-PE+blood AA+blood 0 -0.56127451 0 serum_phospholipids serum_ARA 0.000184 0.212 up up no no no no 18:1/18:0-PE+blood AA+blood 0 -0.531862745 0 serum_phospholipids serum_ARA 1.39E-06 0.212 up up no no no no 18:1/18:0-PI+blood AA+blood 0 -0.637254902 0 serum_phospholipids serum_ARA 0.0931 0.212 no no up no no no 18:1/18:0-PS+blood AA+blood 0.493233083 0 0 serum_phospholipids serum_ARA 0.193 0.212 no no no no no no 18:1/18:1-PE+blood AA+blood 0 -0.573529412 0 serum_phospholipids serum_ARA 1.03E-05 0.212 up up no no no no 18:1/18:1-PG+blood AA+blood 0 -0.691176471 0 serum_phospholipids serum_ARA 0.00352 0.212 no up up no no no 18:1/18:2-PE+blood AA+blood 0 -0.575980392 0 serum_phospholipids serum_ARA 0.000293 0.212 up up no no no no 18:1/18:2-PG+blood AA+blood 0.482706767 -0.580882353 0 serum_phospholipids serum_ARA 5.58E-07 0.212 no up up no no no 18:2/18:2-PS+blood AA+blood 0 -0.536764706 0 serum_phospholipids serum_ARA 0.00674 0.212 up up no no no no 18:3n3+blood AA+blood 0.744360902 0.676470588 0 serum_fattyacid serum_ARA 0.291 0.212 no no no no no no 20:0-LPE+blood AA+blood 0 -0.541666667 0 serum_phospholipids serum_ARA 0.0615 0.212 no no up no no no 20:0/20:4-PE+blood AA+blood 0 -0.625 0 serum_phospholipids serum_ARA 0.00128 0.212 up up no no no no 20:0/20:5-PC+blood AA+blood 0 0 0.426324786 serum_phospholipids serum_ARA 0.882 0.212 no no no no no no 20:2/18:0-PC+blood AA+blood 0 -0.779411765 0 serum_phospholipids serum_ARA 0.0427 0.212 no up no no no no 20:2/18:1-PE+blood AA+blood 0 -0.754901961 0 serum_phospholipids serum_ARA 0.00208 0.212 up up no no no no 20:3/16:0-PC+blood AA+blood 0 0.49754902 0 serum_phospholipids serum_ARA 0.00405 0.212 no up up no no no 20:3n6+blood AA+blood 0 -0.720588235 0 serum_fattyacid serum_ARA 0.0884 0.212 up no no no no no 20:4-LPC+blood AA+blood 0 0.651960784 0.491965812 serum_phospholipids serum_ARA 0.949 0.212 no no no no no no 20:5-LPC+blood AA+blood 0 0.541666667 0 serum_phospholipids serum_ARA 0.558 0.212 no no no no no no 22:1-LPA+blood AA+blood 0.505263158 0 0 serum_phospholipids serum_ARA 0.00373 0.212 no up up no no no 22:6-LPC+blood AA+blood 0 0.615196078 0 serum_phospholipids serum_ARA 0.127 0.212 no no up no no no 24:0+blood AA+blood 0.461654135 0 0 serum_fattyacid serum_ARA 0.034 0.212 dn no up no no no 8-HETE+blood AA+blood 0.670676692 0 0.518632479 serum_ARA serum_ARA 0.741 0.212 no no no no no no 9-HODE+blood AA+blood 0 0.536764706 0 serum_ARA serum_ARA 0.297 0.212 no no no no no no Acetic acid+stool AA+blood 0 0 0.466165414 yes stool_scfa serum_ARA 0.0656 0.212 dn no no no no no Acute myeloid leukemia AA+blood 0 0 0.454615385 kegg serum_ARA NA 0.212 no no no no no no Adipocytokine signaling pathway AA+blood -0.58245614 0 0 kegg serum_ARA NA 0.212 no no no no no no Axon guidance AA+blood 0 -0.664705882 0 kegg serum_ARA NA 0.212 no up up no no no Bifidobacterium AA+blood 0.580669466 0 0 acetate-producing Genus serum_ARA 0.105 0.212 no dn no no no no Butyric acid+stool AA+blood 0 0 0.658646617 yes stool_scfa serum_ARA 0.102 0.212 dn no no no no no Coronavirus disease - COVID-19 AA+blood 0 0 -0.401538462 kegg serum_ARA NA 0.212 no no no no no no Estrogen signaling pathway AA+blood 0 0 -0.402307692 kegg serum_ARA NA 0.212 no no no no no no Fc epsilon RI signaling pathway AA+blood 0 0 0.565384615 kegg serum_ARA NA 0.212 no no no no no no Lipid and atherosclerosis AA+blood 0.471929825 0 0 kegg serum_ARA NA 0.212 no no no no no no MAPK signaling pathway AA+blood 0 0.629411765 0 kegg serum_ARA NA 0.212 no no no no no no Melanogenesis AA+blood 0 0 -0.448461538 kegg serum_ARA NA 0.212 no no no no no no Mitophagy - animal AA+blood -0.503508772 0 0 kegg serum_ARA NA 0.212 no no no no no no nutriCA+stool AA+blood 0 -0.633054165 0 stool_bileacids serum_ARA 0.481 0.212 no no no no no no Paraprevotella AA+blood 0.455720133 0 0 Genus serum_ARA 0.118 0.212 no no no no no no Parkinson disease AA+blood 0 0 -0.45 kegg serum_ARA NA 0.212 no no no no no no Pathways of neurodegeneration - multiple diseases AA+blood 0 0 -0.426923077 kegg serum_ARA NA 0.212 no no no no no no Phospholipase D signaling pathway AA+blood 0 0 0.499230769 kegg serum_ARA NA 0.212 no up up no no no Protein processing in endoplasmic reticulum AA+blood 0 0 -0.579230769 kegg serum_ARA NA 0.212 no no no no no no Renin secretion AA+blood 0 0 -0.42 kegg serum_ARA NA 0.212 no no no no no no Retrograde endocannabinoid signaling AA+blood 0 -0.502941176 0 kegg serum_ARA NA 0.212 no no up no no no Ribosome AA+blood 0 0 -0.401538462 kegg serum_ARA NA 0.212 no no no no no no Roseburia AA+blood 0 -0.580012371 0 butyrate-producing Genus serum_ARA 0.495 0.212 no no no no no no Salmonella infection AA+blood 0.540350877 0 0 kegg serum_ARA NA 0.212 no no no no no no total_stool_scfa+stool AA+blood 0 0 0.518796992 stool_scfa serum_ARA 0.0534 0.212 dn no up no no no alpha-Linolenic acid metabolism ABC transporters 0.529565217 0.504940711 0 kegg kegg NA NA no no no no up up Amino sugar and nucleotide sugar metabolism ABC transporters 0.573043478 0.482213439 0 kegg kegg NA NA no no no no up up Aminoacyl-tRNA biosynthesis ABC transporters 0.66173913 0 0.546203346 kegg kegg NA NA no no no no up up Antifolate resistance ABC transporters 0.652173913 0.482213439 0 kegg kegg NA NA no no no no up up beta-Alanine metabolism ABC transporters 0.492173913 0 0 kegg kegg NA NA no no no no up up Biosynthesis of unsaturated fatty acids ABC transporters 0.434782609 0 0 kegg kegg NA NA no no no no up up Butanoate metabolism ABC transporters 0.56173913 0 0 kegg kegg NA NA no no no no up up Carbon metabolism ABC transporters 0 -0.592885375 0 kegg kegg NA NA no no no no up up Drug metabolism - other enzymes ABC transporters 0 -0.450592885 0 kegg kegg NA NA no no no no up up EGFR tyrosine kinase inhibitor resistance ABC transporters 0 -0.449604743 0 kegg kegg NA NA no no no no up up Endocrine resistance ABC transporters -0.407826087 0 0 kegg kegg NA NA no no no no up up Fatty acid degradation ABC transporters 0.485217391 0 0 kegg kegg NA NA no no no no up up Fatty acid elongation ABC transporters 0 -0.433794466 0 kegg kegg NA NA no no no no up up Fatty acid metabolism ABC transporters 0.471304348 0 0 kegg kegg NA NA no no no no up up Folate biosynthesis ABC transporters 0 0 0.410810811 kegg kegg NA NA no no no no up up Fructose and mannose metabolism ABC transporters 0.597391304 0.513833992 0 kegg kegg NA NA no no no no up up Galactose metabolism ABC transporters 0.572173913 0.464426877 0.404118404 kegg kegg NA NA no no no no up up Glycerolipid metabolism ABC transporters 0.639130435 0.875494071 0.603088803 kegg kegg NA NA no no up no up up Glycerophospholipid metabolism ABC transporters 0 0.837944664 0.622393822 kegg kegg NA NA no no up no up up Glycolysis / Gluconeogenesis ABC transporters 0.410434783 -0.612648221 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate ABC transporters 0 0.563241107 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin ABC transporters 0 0 0.430630631 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate ABC transporters -0.406086957 0 0 kegg kegg NA NA no no no no up up Glycosphingolipid biosynthesis - globo and isoglobo series ABC transporters -0.472173913 0 0 kegg kegg NA NA no no no no up up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis ABC transporters 0.584347826 0.597826087 0 kegg kegg NA NA no no no no up up Histidine metabolism ABC transporters 0.428695652 0 0 kegg kegg NA NA no no no no up up Inositol phosphate metabolism ABC transporters 0.64173913 0.828063241 0.590990991 kegg kegg NA NA no no no no up up Lysine degradation ABC transporters 0.463478261 0.669960474 0.483912484 kegg kegg NA NA no no no no up up Mannose type O-glycan biosynthesis ABC transporters 0 0.578063241 0.491634492 kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis ABC transporters 0 0.456521739 0 kegg kegg NA NA no no no no up up One carbon pool by folate ABC transporters 0.431304348 0 0.536936937 kegg kegg NA NA no no no no up up Other glycan degradation ABC transporters 0.589565217 0.699604743 0.522522523 kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis ABC transporters 0 0.794466403 0.544401544 kegg kegg NA NA no no no no up up Oxidative phosphorylation ABC transporters -0.410434783 -0.433794466 0 kegg kegg NA NA no no no no up up Platinum drug resistance ABC transporters 0 0.847826087 0 kegg kegg NA NA no no no no up up Primary bile acid biosynthesis ABC transporters 0.455652174 0 0 kegg kegg NA NA no no no no up up Propanoate metabolism ABC transporters 0.417391304 0 0 kegg kegg NA NA no no no no up up Pyrimidine metabolism ABC transporters 0.464347826 0 0.692406692 kegg kegg NA NA no no no no up up Pyruvate metabolism ABC transporters 0.467826087 0 0 kegg kegg NA NA no no no no up up Retinol metabolism ABC transporters 0.410434783 0 0 kegg kegg NA NA no no no no up up Selenocompound metabolism ABC transporters 0.446956522 0.733201581 0.64993565 kegg kegg NA NA no no no no up up Starch and sucrose metabolism ABC transporters 0.471304348 0 0 kegg kegg NA NA no no no no up up Synthesis and degradation of ketone bodies ABC transporters 0.431304348 0 0 kegg kegg NA NA no no no no up up Taurine and hypotaurine metabolism ABC transporters 0.424347826 0.806324111 0.504761905 kegg kegg NA NA no no no no up up Thiamine metabolism ABC transporters 0.594782609 0 0 kegg kegg NA NA no no no no up up Tryptophan metabolism ABC transporters 0.513043478 0 0 kegg kegg NA NA no up no no up up Ubiquinone and other terpenoid-quinone biosynthesis ABC transporters 0.572173913 0 0 kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" ABC transporters 0.562608696 0 0 kegg kegg NA NA no no no no up up 16:0/16:0-PI+blood ACA+blood -0.504511257 0 0 serum_phospholipids serum_bileacids 0.358 0.338 no no no no no no 16:0/18:1-PC+blood ACA+blood 0.475590229 0 0 serum_phospholipids serum_bileacids 6.15E-07 0.338 up up up no no no 16:0/18:1-PE+blood ACA+blood -0.573600378 0 0 serum_phospholipids serum_bileacids 0.000107 0.338 up up no no no no 16:0/18:2-PC+blood ACA+blood 0.508528066 0 0 serum_phospholipids serum_bileacids 3.24E-06 0.338 no up up no no no 16:0/20:4-PC+blood ACA+blood 0.509331428 0 0 serum_phospholipids serum_bileacids 0.0262 0.338 no up no no no no 16:0/22:6-PE+blood ACA+blood -0.568780206 0 0 serum_phospholipids serum_bileacids 0.000934 0.338 up up no no no no 18:0/18:1-PE+blood ACA+blood 0 0 -0.410615571 serum_phospholipids serum_bileacids 0.00716 0.338 up up no no no no 18:0/18:2-PI+blood ACA+blood 0 -0.605201587 0 serum_phospholipids serum_bileacids 0.179 0.338 no no no no no no 18:0/20:5-PC+blood ACA+blood 0 0.583913089 0 serum_phospholipids serum_bileacids 0.17 0.338 no no no no no no 18:0/22:6-PE+blood ACA+blood -0.485230572 0 0 serum_phospholipids serum_bileacids 0.00022 0.338 up up no no no no 18:0/22:6-PI+blood ACA+blood -0.448275925 0 0 serum_phospholipids serum_bileacids 0.425 0.338 no no no no no no 18:1/16:0-PC+blood ACA+blood 0.545482712 0 0 serum_phospholipids serum_bileacids 2.43E-05 0.338 no up up no no no 18:1/16:1-PE+blood ACA+blood -0.453899459 0 0 serum_phospholipids serum_bileacids 0.000184 0.338 up up no no no no 18:1/18:0-PC+blood ACA+blood 0.495674276 0 0 serum_phospholipids serum_bileacids 1.83E-06 0.338 no up up no no no 18:1/18:1-PC+blood ACA+blood 0.456309544 0 0 serum_phospholipids serum_bileacids 1.34E-05 0.338 no up up no no no 18:1/18:1-PE+blood ACA+blood -0.459522992 0 0 serum_phospholipids serum_bileacids 1.03E-05 0.338 up up no no no no 18:1/18:2-PE+blood ACA+blood -0.555926416 0 0 serum_phospholipids serum_bileacids 0.000293 0.338 up up no no no no 18:1/22:6-PE+blood ACA+blood -0.449882649 0 0 serum_phospholipids serum_bileacids 0.0047 0.338 no up no no no no 18:2-LPA+blood ACA+blood 0 0 0.424125001 serum_phospholipids serum_bileacids 0.00684 0.338 dn no up no no no 18:2-LPE+blood ACA+blood 0 -0.538294879 0 serum_phospholipids serum_bileacids 0.112 0.338 no no no no no no 20:0-LPE+blood ACA+blood -0.562353311 -0.495717882 0 serum_phospholipids serum_bileacids 0.0615 0.338 no no up no no no 20:0/20:4-PE+blood ACA+blood 0 0 -0.410615571 serum_phospholipids serum_bileacids 0.00128 0.338 up up no no no no 20:1/20:4-PE+blood ACA+blood 0 0 -0.470341472 serum_phospholipids serum_bileacids 0.0042 0.338 up up no no no no 20:2/18:1-PE+blood ACA+blood -0.520578494 0 0 serum_phospholipids serum_bileacids 0.00208 0.338 up up no no no no 20:3/16:0-PC+blood ACA+blood 0.596897872 0 0 serum_phospholipids serum_bileacids 0.00405 0.338 no up up no no no 20:3/18:0-PC+blood ACA+blood 0 0 0.525801238 serum_phospholipids serum_bileacids 0.296 0.338 no no no no no no 20:4-LPC+blood ACA+blood 0 0.48659424 0 serum_phospholipids serum_bileacids 0.949 0.338 no no no no no no 20:4/16:0-PE+blood ACA+blood -0.451489373 0 0 serum_phospholipids serum_bileacids 0.00529 0.338 no up up no no no 20:4n6+blood ACA+blood 0 0.696438007 0 serum_fattyacid serum_bileacids 0.133 0.338 no no no no no no 20:5-LPC+blood ACA+blood 0 0.513965167 0 serum_phospholipids serum_bileacids 0.558 0.338 no no no no no no 22:2-LPA+blood ACA+blood 0 -0.489635454 0.528645328 serum_phospholipids serum_bileacids 0.0443 0.338 dn no no no no no 24:1+blood ACA+blood 0 0 0.482428857 serum_fattyacid serum_bileacids 0.00582 0.338 no dn dn no no no 4-hydroxybenzoic acid+stool ACA+blood 0 0 0.467639998 stool_cometabolism serum_bileacids 0.0536 0.338 no dn no no no no 8-HETE+blood ACA+blood 0 0 -0.412037616 serum_ARA serum_bileacids 0.741 0.338 no no no no no no Adherens junction ACA+blood 0 0 0.533854518 kegg serum_bileacids NA 0.338 no no no no no no AMPK signaling pathway ACA+blood 0.561979033 0 0 kegg serum_bileacids NA 0.338 no no no no no no Arrhythmogenic right ventricular cardiomyopathy ACA+blood 0 0 0.513754574 kegg serum_bileacids NA 0.338 no up up no no no Autophagy - animal ACA+blood 0 0 -0.481594663 kegg serum_bileacids NA 0.338 no no no no no no Bacterial invasion of epithelial cells ACA+blood 0 0 0.442198772 kegg serum_bileacids NA 0.338 no no no no no no Blautia ACA+blood -0.447472564 0 0 acetate-producing Genus serum_bileacids 1.36E-05 0.338 up dn dn no no no Breast cancer ACA+blood 0 0 -0.463906712 kegg serum_bileacids NA 0.338 no no no no no no Butyric acid+stool ACA+blood 0 -0.674126972 0 yes stool_scfa serum_bileacids 0.102 0.338 dn no no no no no CA+stool ACA+blood -0.633020982 0 0 stool_bileacids serum_bileacids 0.827 0.338 no no no no no no Choline metabolism in cancer ACA+blood 0 0 -0.467122703 kegg serum_bileacids NA 0.338 no no no no no no Cholinergic synapse ACA+blood 0 0.519696405 0 kegg serum_bileacids NA 0.338 no no no no no no Chronic myeloid leukemia ACA+blood 0 0 -0.409234864 kegg serum_bileacids NA 0.338 no no no no no no Clostridium ACA+blood -0.495057061 0 0 Genus serum_bileacids 0.925 0.338 no no no no no no Clostridium ACA+blood -0.537336186 0 0 Genus serum_bileacids 0.925 0.338 no no no no no no Cytokine-cytokine receptor interaction ACA+blood 0 0 0.478378672 kegg serum_bileacids NA 0.338 no no no no no no DCA+stool ACA+blood 0 0 -0.579500728 stool_bileacids serum_bileacids 0.195 0.338 no no no no no no ErbB signaling pathway ACA+blood 0 0 -0.447022759 kegg serum_bileacids NA 0.338 no no no no no no Fluid shear stress and atherosclerosis ACA+blood 0 0 0.45747473 kegg serum_bileacids NA 0.338 no no no no no no Gastric acid secretion ACA+blood 0 0 0.460690721 kegg serum_bileacids NA 0.338 no no no no no no Gastric cancer ACA+blood 0 0 -0.439786779 kegg serum_bileacids NA 0.338 no no no no no no Glioma ACA+blood 0 0.546743802 0 kegg serum_bileacids NA 0.338 no no no no no no Glutamatergic synapse ACA+blood 0.491499814 0 0 kegg serum_bileacids NA 0.338 no up up no no no HCA+stool ACA+blood -0.633020982 0 0 stool_bileacids serum_bileacids 0.155 0.338 no no no no no no Hepatitis B ACA+blood -0.510046977 0 0 kegg serum_bileacids NA 0.338 no no no no no no Hypertrophic cardiomyopathy ACA+blood 0 0 0.487222647 kegg serum_bileacids NA 0.338 no up up no no no IL-17 signaling pathway ACA+blood -0.615765805 0 0 kegg serum_bileacids NA 0.338 no no no no no no Influenza A ACA+blood 0 0 0.455062737 kegg serum_bileacids NA 0.338 no no no no no no Intestinal immune network for IgA production ACA+blood 0.545286586 0 0 kegg serum_bileacids NA 0.338 no no no no no no Kaposi sarcoma-associated herpesvirus infection ACA+blood 0 -0.566063371 0 kegg serum_bileacids NA 0.338 no no dn no no no LCA+stool ACA+blood 0 0 -0.527454416 stool_bileacids serum_bileacids 0.314 0.338 no no no no no no Leukocyte transendothelial migration ACA+blood 0 0 0.454258739 kegg serum_bileacids NA 0.338 no no no no no no Lipid and atherosclerosis ACA+blood -0.587945061 0 0 kegg serum_bileacids NA 0.338 no no no no no no Malaria ACA+blood 0 -0.5602675 0 kegg serum_bileacids NA 0.338 no no no no no no MAPK signaling pathway ACA+blood 0 0.556403586 0 kegg serum_bileacids NA 0.338 no no no no no no Measles ACA+blood -0.552705452 0 0 kegg serum_bileacids NA 0.338 no no no no no no Mineral absorption ACA+blood 0 -0.577655112 0 kegg serum_bileacids NA 0.338 no no no no no no Morphine addiction ACA+blood 0.480371517 0 0 kegg serum_bileacids NA 0.338 no up up no no no Necroptosis ACA+blood 0 -0.564131414 0 kegg serum_bileacids NA 0.338 no no no no no no NF-kappa B signaling pathway ACA+blood -0.658424279 0 0 kegg serum_bileacids NA 0.338 no no no no no no nutriCA+stool ACA+blood -0.582153224 0 0 stool_bileacids serum_bileacids 0.481 0.338 no no no no no no Olfactory transduction ACA+blood -0.582380912 0 0 kegg serum_bileacids NA 0.338 no no no no no no Osteoclast differentiation ACA+blood -0.580526196 0 0 kegg serum_bileacids NA 0.338 no no no no no no Oxytocin signaling pathway ACA+blood 0 0 0.456670732 kegg serum_bileacids NA 0.338 no no no no no no p53 signaling pathway ACA+blood 0 0 -0.512950576 kegg serum_bileacids NA 0.338 no no no no no no Pancreatic cancer ACA+blood 0 0 -0.567622424 kegg serum_bileacids NA 0.338 no no no no no no Pathogenic Escherichia coli infection ACA+blood 0 0 0.451042748 kegg serum_bileacids NA 0.338 no no no no no no Phagosome ACA+blood 0 0 0.41084286 kegg serum_bileacids NA 0.338 no no no no no no Phosphatidylinositol signaling system ACA+blood 0 0.633681862 0 kegg serum_bileacids NA 0.338 no no no no no no Platinum drug resistance ACA+blood 0 0 -0.456670732 kegg serum_bileacids NA 0.338 no no no no no no Propionic acid+stool ACA+blood 0 0 -0.620671691 yes stool_scfa serum_bileacids 0.0436 0.338 dn no up no no no Rap1 signaling pathway ACA+blood 0 0 0.400390889 kegg serum_bileacids NA 0.338 no no no no no no Renal cell carcinoma ACA+blood 0 0 -0.545914485 kegg serum_bileacids NA 0.338 no no no no no no Renin secretion ACA+blood 0.515611126 0 0 kegg serum_bileacids NA 0.338 no no no no no no RIG-I-like receptor signaling pathway ACA+blood -0.489645098 0 0 kegg serum_bileacids NA 0.338 no no no no no no Salivary secretion ACA+blood 0.539722438 0 0 kegg serum_bileacids NA 0.338 no no no no no no Salmonella infection ACA+blood 0 0 0.477574674 kegg serum_bileacids NA 0.338 no no no no no no Shigellosis ACA+blood 0 -0.666525129 0 kegg serum_bileacids NA 0.338 no no no no no no Small cell lung cancer ACA+blood 0 0 -0.459082726 kegg serum_bileacids NA 0.338 no no up no no no Thyroid hormone synthesis ACA+blood 0.491499814 0 0 kegg serum_bileacids NA 0.338 no no no no no no total_stool_scfa+stool ACA+blood 0 0 -0.467639998 stool_scfa serum_bileacids 0.0534 0.338 dn no up no no no Transcriptional misregulation in cancer ACA+blood -0.491499814 0 0 kegg serum_bileacids NA 0.338 no no no no no no Vibrio cholerae infection ACA+blood 0 0 0.508930587 kegg serum_bileacids NA 0.338 no no no no no no Yersinia infection ACA+blood 0 0 0.478378672 kegg serum_bileacids NA 0.338 no no no no no no 4-hydroxybenzoic acid+stool ACA+stool -0.540854486 0 0 stool_cometabolism stool_bileacids 0.0536 0.417 no dn no no no no AGE-RAGE signaling pathway in diabetic complications ACA+stool 0.598627579 0 0 kegg stool_bileacids NA 0.417 no no no no no no Breast cancer ACA+stool 0.608461297 0 0 kegg stool_bileacids NA 0.417 no no no no no no Chagas disease ACA+stool 0.577730928 0 0 kegg stool_bileacids NA 0.417 no no no no no no Choline metabolism in cancer ACA+stool 0.485539823 0 -0.445347476 kegg stool_bileacids NA 0.417 no no no no no no Cholinergic synapse ACA+stool 0.515040976 0 0 kegg stool_bileacids NA 0.417 no no no no no no Chronic myeloid leukemia ACA+stool 0.57035564 0 0 kegg stool_bileacids NA 0.417 no no no no no no ErbB signaling pathway ACA+stool 0.669922034 0 0 kegg stool_bileacids NA 0.417 no no no no no no Fc epsilon RI signaling pathway ACA+stool 0.519957835 0 0 kegg stool_bileacids NA 0.417 no no no no no no Gastric cancer ACA+stool 0.501519614 0 0 kegg stool_bileacids NA 0.417 no no no no no no "Growth hormone synthesis, secretion and action" ACA+stool 0.604773652 0 0 kegg stool_bileacids NA 0.417 no no no no no no Hepatitis B ACA+stool 0.519957835 0 0 kegg stool_bileacids NA 0.417 no no no no no no Influenza A ACA+stool 0 0 0.492226158 kegg stool_bileacids NA 0.417 no no no no no no Intestinal immune network for IgA production ACA+stool 0.575272499 0 0 kegg stool_bileacids NA 0.417 no no no no no no Neurotrophin signaling pathway ACA+stool 0.535937627 0 0 kegg stool_bileacids NA 0.417 no no no no no no Non-small cell lung cancer ACA+stool 0.694506328 0 0 kegg stool_bileacids NA 0.417 no no no no no no Phosphatidylinositol signaling system ACA+stool 0 0 -0.534036874 kegg stool_bileacids NA 0.417 no no no no no no Phospholipase D signaling pathway ACA+stool 0.527333124 0 0 kegg stool_bileacids NA 0.417 no up up no no no Prevotella ACA+stool -0.473298757 0 0 Genus stool_bileacids 0.367 0.417 no no no no no no Primary immunodeficiency ACA+stool -0.478164534 0 0 kegg stool_bileacids NA 0.417 no no no no no no Prolactin signaling pathway ACA+stool 0.533479197 0 0 kegg stool_bileacids NA 0.417 no no no no no no Prostate cancer ACA+stool 0.59371072 0 0 kegg stool_bileacids NA 0.417 no no no no no no Ras signaling pathway ACA+stool 0 0 -0.445347476 yes kegg stool_bileacids NA 0.417 no up up no no no Renal cell carcinoma ACA+stool 0 0 -0.508697046 kegg stool_bileacids NA 0.417 no no no no no no Roseburia ACA+stool -0.54454213 0 0 butyrate-producing Genus stool_bileacids 0.495 0.417 no no no no no no Signaling pathways regulating pluripotency of stem cells ACA+stool 0.468330816 0 0 kegg stool_bileacids NA 0.417 no no no no no no TNF signaling pathway ACA+stool 0.537166842 0 0 kegg stool_bileacids NA 0.417 no no no no no no Toll-like receptor signaling pathway ACA+stool 0.608461297 0 0 yes kegg stool_bileacids NA 0.417 no no no no no no VEGF signaling pathway ACA+stool 0.479393749 0 0 kegg stool_bileacids NA 0.417 no no no no no no Wnt signaling pathway ACA+stool 0 0 -0.449148451 kegg stool_bileacids NA 0.417 no no no no no no ¦Ø-MCA+stool ACA+stool 0 0.635403002 0 stool_bileacids stool_bileacids 0.919 0.417 no no no no no no 14:0-LPC+blood acetic acid C2+blood 0 0 -0.418803419 serum_phospholipids serum_scfa 0.00689 0.000193 up up no up dn no 14:0/16:0-PC+blood acetic acid C2+blood 0 -0.536764706 0 serum_phospholipids serum_scfa 0.0358 0.000193 no up no up dn no 14:0/18:0-PC+blood acetic acid C2+blood -0.538345865 0 0 serum_phospholipids serum_scfa 0.00289 0.000193 up up no up dn no 14:0/18:2-PC+blood acetic acid C2+blood 0 0 -0.433846154 serum_phospholipids serum_scfa 0.102 0.000193 no up no up dn no 14:0/20:4-PC+blood acetic acid C2+blood 0 0 -0.402393162 serum_phospholipids serum_scfa 0.486 0.000193 no no no up dn no 14:1/18:2-PG+blood acetic acid C2+blood 0 0 -0.409230769 serum_phospholipids serum_scfa 0.00259 0.000193 no up up up dn no 15-HETE+blood acetic acid C2+blood 0 0.499392968 0 serum_ARA serum_scfa 0.819 0.000193 no no no up dn no 16:0/14:0-PC+blood acetic acid C2+blood 0 -0.620098039 0 serum_phospholipids serum_scfa 0.0206 0.000193 no up up up dn no 16:0/16:0-PI+blood acetic acid C2+blood 0 0 -0.44957265 serum_phospholipids serum_scfa 0.358 0.000193 no no no up dn no 16:0/16:1-PC+blood acetic acid C2+blood -0.57593985 0 0 serum_phospholipids serum_scfa 0.00283 0.000193 up up no up dn no 16:0/18:1-PC+blood acetic acid C2+blood 0 -0.571078431 0 serum_phospholipids serum_scfa 6.15E-07 0.000193 up up up up dn no 16:0/18:2-PC+blood acetic acid C2+blood 0 -0.551470588 0 serum_phospholipids serum_scfa 3.24E-06 0.000193 no up up up dn no 16:0/20:3-PC+blood acetic acid C2+blood 0 -0.56127451 0 serum_phospholipids serum_scfa 5.43E-06 0.000193 no up up up dn no 16:0/22:0-PE+blood acetic acid C2+blood 0.454135338 0 0 serum_phospholipids serum_scfa 0.00839 0.000193 dn no up up dn no 16:0/22:6-PC+blood acetic acid C2+blood 0.460150376 0 0 serum_phospholipids serum_scfa 4.53E-05 0.000193 no up up up dn no 18:0-LPC+blood acetic acid C2+blood 0.496240602 0.509803922 0 serum_phospholipids serum_scfa 0.554 0.000193 no no no up dn no 18:0-LPE+blood acetic acid C2+blood 0.57593985 0.617647059 0 serum_phospholipids serum_scfa 0.491 0.000193 no no no up dn no 18:0/16:0-PC+blood acetic acid C2+blood 0 -0.534313725 0 serum_phospholipids serum_scfa 9.64E-07 0.000193 up up up up dn no 18:0/18:2-PC+blood acetic acid C2+blood 0 -0.625 0 serum_phospholipids serum_scfa 1.74E-06 0.000193 no up up up dn no 18:0/22:6-PA+blood acetic acid C2+blood 0 0 -0.404444444 serum_phospholipids serum_scfa 0.22 0.000193 no no no up dn no 18:0/22:6-PE+blood acetic acid C2+blood 0.518796992 0 0 serum_phospholipids serum_scfa 0.00022 0.000193 up up no up dn no 18:0/22:6-PI+blood acetic acid C2+blood 0.49924812 0 0 serum_phospholipids serum_scfa 0.425 0.000193 no no no up dn no 18:1/16:0-PC+blood acetic acid C2+blood 0 -0.504901961 0 serum_phospholipids serum_scfa 2.43E-05 0.000193 no up up up dn no 18:1/18:0-PC+blood acetic acid C2+blood 0 -0.637254902 0 serum_phospholipids serum_scfa 1.83E-06 0.000193 no up up up dn no 18:1/18:1-PC+blood acetic acid C2+blood 0 -0.566176471 0 serum_phospholipids serum_scfa 1.34E-05 0.000193 no up up up dn no 18:1/18:2-PI+blood acetic acid C2+blood 0 0.490196078 0 serum_phospholipids serum_scfa 0.0164 0.000193 dn no up up dn no 18:1/22:6-PE+blood acetic acid C2+blood 0.508270677 0 0 serum_phospholipids serum_scfa 0.0047 0.000193 no up no up dn no 18:3-LPC+blood acetic acid C2+blood -0.49924812 0 0 serum_phospholipids serum_scfa 0.147 0.000193 no no no up dn no 20:0-LPE+blood acetic acid C2+blood 0 0.615196078 0 serum_phospholipids serum_scfa 0.0615 0.000193 no no up up dn no 22:0/16:0-PE+blood acetic acid C2+blood 0.596992481 0 0 serum_phospholipids serum_scfa 0.091 0.000193 no no up up dn no 22:6n3+blood acetic acid C2+blood 0.503759398 0 0 serum_fattyacid serum_scfa 0.792 0.000193 no no no up dn no 4-hydroxybenzoic acid+stool Acetic acid+stool 0.494324045 0 0 yes stool_cometabolism stool_scfa 0.0536 0.0656 no dn no dn no no 5-Hydroxytryptamine+stool Acetic acid+stool 0 0 -0.421936759 yes stool_cometabolism stool_scfa 0.00862 0.0656 dn dn no dn no no ACA+stool Acetic acid+stool -0.507665688 0 0 yes stool_bileacids stool_scfa 0.417 0.0656 no no no dn no no Akkermansia Acetic acid+stool -0.564765508 0 0 acetate-producing yes Genus stool_scfa 0.23 0.0656 no no no dn no no Alcoholism Acetic acid+stool 0 0 -0.45567476 yes kegg stool_scfa NA 0.0656 no no no dn no no Amoebiasis Acetic acid+stool -0.525283798 0 0 yes kegg stool_scfa NA 0.0656 no no no dn no no Chemokine signaling pathway Acetic acid+stool -0.523219814 0 0 yes kegg stool_scfa NA 0.0656 no no no dn no no Clostridium Acetic acid+stool 0 0 -0.432908329 yes Genus stool_scfa 0.925 0.0656 no no no dn no no Clostridium Acetic acid+stool 0 0 0.426982963 yes Genus stool_scfa 0.925 0.0656 no no no dn no no Phospholipase D signaling pathway Acetic acid+stool -0.541795666 0 0 yes kegg stool_scfa NA 0.0656 no up up dn no no Porphyrin and chlorophyll metabolism Acetic acid+stool 0.471620227 0 0 yes kegg stool_scfa NA 0.0656 no no no dn no no Prevotella Acetic acid+stool 0 -0.694060061 0 acetate-producing yes Genus stool_scfa 0.287 0.0656 no no no dn no no Rheumatoid arthritis Acetic acid+stool -0.500515996 0 0 yes kegg stool_scfa NA 0.0656 no no no dn no no ¦Ø-MCA+stool Acetic acid+stool -0.478104177 0 0 yes stool_bileacids stool_scfa 0.919 0.0656 no no no dn no no 2-Oxocarboxylic acid metabolism Acute myeloid leukemia -0.544347826 -0.654150198 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Acute myeloid leukemia 0.411304348 0.545454545 0 kegg kegg NA NA no no no no no no African trypanosomiasis Acute myeloid leukemia 0.509565217 0 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Acute myeloid leukemia 0.42173913 0.774703557 0.511711712 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Acute myeloid leukemia 0.419130435 0.606719368 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Acute myeloid leukemia 0.649565217 0.738142292 0.528957529 kegg kegg NA NA no no no no no no Alzheimer disease Acute myeloid leukemia 0 -0.511857708 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Acute myeloid leukemia -0.44 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Acute myeloid leukemia -0.479130435 -0.636363636 0 kegg kegg NA NA no no no no no no Amoebiasis Acute myeloid leukemia 0.49826087 0.801383399 0 kegg kegg NA NA no no no no no no Amphetamine addiction Acute myeloid leukemia 0 -0.54743083 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Acute myeloid leukemia 0 -0.552371542 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Acute myeloid leukemia 0 -0.653162055 -0.443500644 kegg kegg NA NA no no no no no no Apoptosis Acute myeloid leukemia 0 0.714426877 0.478507079 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Acute myeloid leukemia -0.469565217 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Acute myeloid leukemia 0 0.673913043 0.417760618 kegg kegg NA NA no up no no no no Arginine biosynthesis Acute myeloid leukemia 0.442608696 0.589920949 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Acute myeloid leukemia -0.430434783 0 0 kegg kegg NA NA no no no no no no Autophagy - animal Acute myeloid leukemia 0.486956522 0.712450593 0.555212355 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Acute myeloid leukemia 0.410434783 0.742094862 0.642213642 kegg kegg NA NA no no no no no no Bacteroides Acute myeloid leukemia 0 -0.536561265 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Acute myeloid leukemia 0 -0.496047431 0 kegg kegg NA NA no no no no no no Base excision repair Acute myeloid leukemia -0.467826087 0 -0.402316602 kegg kegg NA NA no no no no no no beta-Alanine metabolism Acute myeloid leukemia -0.447826087 -0.613636364 -0.419305019 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Acute myeloid leukemia 0 0.41798419 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Acute myeloid leukemia -0.56 -0.524703557 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Acute myeloid leukemia -0.710434783 -0.641304348 -0.456370656 kegg kegg NA NA no no no no no no Bladder cancer Acute myeloid leukemia 0.563478261 0.836956522 0.591248391 kegg kegg NA NA no no no no no no Butanoate metabolism Acute myeloid leukemia -0.595652174 -0.863636364 -0.652767053 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Acute myeloid leukemia 0.686956522 0.736166008 0.718918919 kegg kegg NA NA no no no no no no cAMP signaling pathway Acute myeloid leukemia 0 0.584980237 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Acute myeloid leukemia 0.582608696 0.740118577 0.568597169 kegg kegg NA NA no no no no no no Cardiac muscle contraction Acute myeloid leukemia 0 -0.479249012 0 kegg kegg NA NA no no up no no no Cell cycle Acute myeloid leukemia -0.464347826 -0.550395257 0 kegg kegg NA NA no no no no no no Cellular senescence Acute myeloid leukemia 0 0.543478261 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Acute myeloid leukemia 0.595652174 0.57312253 0 kegg kegg NA NA no no no no no no Chagas disease Acute myeloid leukemia 0.437391304 0.756916996 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Acute myeloid leukemia 0.49826087 0.675889328 0 kegg kegg NA NA no no no no no no Cholesterol metabolism Acute myeloid leukemia 0 0 0.408494208 yes kegg kegg NA NA no no up no no no Chronic myeloid leukemia Acute myeloid leukemia 0.484347826 0.730237154 0.604890605 kegg kegg NA NA no no no no no no Circadian entrainment Acute myeloid leukemia 0 -0.461462451 -0.43011583 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Acute myeloid leukemia -0.646956522 -0.878458498 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Acute myeloid leukemia 0 0.510869565 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Acute myeloid leukemia 0 -0.499011858 -0.450965251 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Acute myeloid leukemia -0.562608696 -0.83201581 -0.574259974 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Acute myeloid leukemia 0 0.475296443 0 kegg kegg NA NA no no no no no no DNA replication Acute myeloid leukemia -0.66 -0.813241107 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Acute myeloid leukemia -0.482608696 -0.759881423 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Acute myeloid leukemia 0 -0.70256917 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Acute myeloid leukemia -0.704347826 0 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Acute myeloid leukemia 0 -0.490118577 0 kegg kegg NA NA no no no no no no Endometrial cancer Acute myeloid leukemia 0.766086957 0.848814229 0.55032175 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Acute myeloid leukemia 0.548695652 0.636363636 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Acute myeloid leukemia 0.544347826 0.62944664 0.435006435 kegg kegg NA NA no no no no no no Estrogen signaling pathway Acute myeloid leukemia -0.527826087 -0.718379447 -0.497039897 kegg kegg NA NA no no no no no no Ether lipid metabolism Acute myeloid leukemia 0 -0.459486166 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Acute myeloid leukemia -0.587826087 -0.481225296 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Acute myeloid leukemia 0.493043478 0.617588933 0.518918919 kegg kegg NA NA no no no no no no Fatty acid elongation Acute myeloid leukemia -0.522608696 -0.579051383 -0.486743887 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Acute myeloid leukemia 0.72173913 0.805335968 0.801544402 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Acute myeloid leukemia 0 0.421936759 0 kegg kegg NA NA no no no no no no Ferroptosis Acute myeloid leukemia 0 0.476284585 0 kegg kegg NA NA no no no no no no Focal adhesion Acute myeloid leukemia 0 -0.467391304 0 kegg kegg NA NA no up up no no no Fructose and mannose metabolism Acute myeloid leukemia 0 0.442687747 0 kegg kegg NA NA no no no no no no GABAergic synapse Acute myeloid leukemia 0 0.532608696 0 kegg kegg NA NA no up up no no no Gastric acid secretion Acute myeloid leukemia 0 -0.43972332 0 kegg kegg NA NA no no no no no no Glioma Acute myeloid leukemia 0.416521739 0 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Acute myeloid leukemia 0 -0.531620553 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Acute myeloid leukemia 0 0.470355731 0 kegg kegg NA NA no up up no no no Glutathione metabolism Acute myeloid leukemia -0.413913043 -0.42687747 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Acute myeloid leukemia -0.44173913 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Acute myeloid leukemia -0.517391304 -0.681818182 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Acute myeloid leukemia 0.724347826 0.788537549 0.477734878 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Acute myeloid leukemia 0.435652174 0 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Acute myeloid leukemia 0 -0.520750988 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Acute myeloid leukemia 0.413913043 0.45256917 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Acute myeloid leukemia 0 0.604743083 0 kegg kegg NA NA no no no no no no GnRH secretion Acute myeloid leukemia 0.611304348 0.683794466 0.529214929 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Acute myeloid leukemia 0.476521739 0.551383399 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Acute myeloid leukemia 0 -0.454545455 0 kegg kegg NA NA no no no no no no Hepatitis B Acute myeloid leukemia 0.495652174 0.700592885 0.696782497 kegg kegg NA NA no no no no no no Hepatitis C Acute myeloid leukemia 0.417391304 0.510869565 0.582239382 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Acute myeloid leukemia 0 -0.514822134 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Acute myeloid leukemia 0 -0.450592885 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Acute myeloid leukemia 0 0.505928854 0.485456885 kegg kegg NA NA no no no no no no Homologous recombination Acute myeloid leukemia -0.46173913 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Acute myeloid leukemia 0 0.568181818 0 kegg kegg NA NA no no no no no no Huntington disease Acute myeloid leukemia 0 -0.514822134 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Acute myeloid leukemia 0.571304348 0.595849802 0.535392535 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Acute myeloid leukemia 0 -0.48715415 0 kegg kegg NA NA no no no no no no Insulin resistance Acute myeloid leukemia 0 0.760869565 0.521750322 kegg kegg NA NA no no no no no no Insulin signaling pathway Acute myeloid leukemia 0 -0.593873518 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Acute myeloid leukemia 0.452173913 0.572134387 0.428314028 kegg kegg NA NA no no no no no no Legionellosis Acute myeloid leukemia 0 0 -0.458172458 kegg kegg NA NA no no no no no no Leishmaniasis Acute myeloid leukemia -0.428695652 0 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Acute myeloid leukemia 0 -0.420948617 0 kegg kegg NA NA no no no no no no Long-term potentiation Acute myeloid leukemia 0 -0.685770751 0 kegg kegg NA NA no no up no no no Lysosome Acute myeloid leukemia 0.593043478 0.434782609 0.502187902 kegg kegg NA NA no no no no no no Melanogenesis Acute myeloid leukemia 0 -0.470355731 0 kegg kegg NA NA no no no no no no Melanoma Acute myeloid leukemia 0.719130435 0.831027668 0.606177606 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Acute myeloid leukemia -0.449565217 -0.768774704 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Acute myeloid leukemia 0 0.785573123 0.48030888 kegg kegg NA NA no no no no no no Mismatch repair Acute myeloid leukemia -0.772173913 -0.779644269 -0.561904762 kegg kegg NA NA no no no no no no mTOR signaling pathway Acute myeloid leukemia 0 -0.488142292 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Acute myeloid leukemia -0.452173913 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Acute myeloid leukemia 0 -0.611660079 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Acute myeloid leukemia 0 0.43083004 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Acute myeloid leukemia 0.502608696 0.729249012 0.484169884 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Acute myeloid leukemia 0 0.453557312 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Acute myeloid leukemia 0 0.758893281 0.663063063 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Acute myeloid leukemia 0.514782609 0.701581028 0.517889318 kegg kegg NA NA no no no no no no Nicotine addiction Acute myeloid leukemia 0 0 0.441698842 kegg kegg NA NA no up up no no no Nitrogen metabolism Acute myeloid leukemia 0.454782609 0.621541502 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Acute myeloid leukemia 0 0.609683794 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Acute myeloid leukemia 0 -0.415019763 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Acute myeloid leukemia -0.613913043 -0.684782609 -0.568339768 kegg kegg NA NA no no no no no no Notch signaling pathway Acute myeloid leukemia 0.557391304 0.575098814 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Acute myeloid leukemia -0.7 -0.777667984 -0.5001287 kegg kegg NA NA no no no no no no One carbon pool by folate Acute myeloid leukemia -0.603478261 -0.65513834 0 kegg kegg NA NA no no no no no no Oocyte meiosis Acute myeloid leukemia 0 -0.73715415 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Acute myeloid leukemia 0.508695652 0.619565217 0.623423423 kegg kegg NA NA no no no no no no Oxidative phosphorylation Acute myeloid leukemia 0 -0.500988142 0 kegg kegg NA NA no no no no no no Pancreatic cancer Acute myeloid leukemia 0.566956522 0 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Acute myeloid leukemia 0.429565217 0.469367589 0 kegg kegg NA NA no no dn no no no Parkinson disease Acute myeloid leukemia 0 -0.449604743 -0.411068211 kegg kegg NA NA no no no no no no Pathways in cancer Acute myeloid leukemia 0 0.591897233 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Acute myeloid leukemia 0 -0.453557312 -0.427541828 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Acute myeloid leukemia -0.736521739 -0.849802372 -0.445302445 kegg kegg NA NA no no no no no no Pentose phosphate pathway Acute myeloid leukemia 0 0.469367589 0 kegg kegg NA NA no no no no no no Pertussis Acute myeloid leukemia 0 0.466403162 0 kegg kegg NA NA no no dn no no no Phenylalanine metabolism Acute myeloid leukemia -0.435652174 -0.741106719 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Acute myeloid leukemia 0.609565217 0.76284585 0.510939511 kegg kegg NA NA no up up no no no Phototransduction Acute myeloid leukemia 0 -0.690711462 -0.61029601 kegg kegg NA NA no no no no no no PPAR signaling pathway Acute myeloid leukemia 0 0.58201581 0 kegg kegg NA NA no no no no no no Prevotella Acute myeloid leukemia 0 0.417710244 0 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Acute myeloid leukemia -0.734782609 -0.66798419 0 kegg kegg NA NA no no no no no no Prion disease Acute myeloid leukemia 0 -0.605731225 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Acute myeloid leukemia 0.747826087 0.753952569 0.749292149 kegg kegg NA NA no no no no no no Propanoate metabolism Acute myeloid leukemia -0.5 -0.791501976 -0.515830116 kegg kegg NA NA no no no no no no Prostate cancer Acute myeloid leukemia 0.484347826 0.756916996 0.567310167 kegg kegg NA NA no no no no no no Proteasome Acute myeloid leukemia 0 -0.668972332 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Acute myeloid leukemia 0 0 0.51994852 yes kegg kegg NA NA no up up no no no Protein export Acute myeloid leukemia 0 -0.622529644 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Acute myeloid leukemia -0.674782609 -0.66798419 -0.566795367 kegg kegg NA NA no no no no no no Proteoglycans in cancer Acute myeloid leukemia 0 -0.45256917 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Acute myeloid leukemia -0.703478261 -0.643280632 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Acute myeloid leukemia 0 -0.62055336 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Acute myeloid leukemia -0.585217391 -0.831027668 -0.547490347 kegg kegg NA NA no no no no no no Ras signaling pathway Acute myeloid leukemia 0 -0.515810277 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Acute myeloid leukemia 0 -0.507905138 -0.509137709 kegg kegg NA NA no no no no no no Relaxin signaling pathway Acute myeloid leukemia 0 0.697628458 0 kegg kegg NA NA no no no no no no Renin secretion Acute myeloid leukemia 0 -0.557312253 -0.420592021 kegg kegg NA NA no no no no no no Renin-angiotensin system Acute myeloid leukemia 0 0.47826087 0 kegg kegg NA NA no no no no no no Retinol metabolism Acute myeloid leukemia -0.507826087 -0.684782609 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Acute myeloid leukemia 0 -0.540513834 0 kegg kegg NA NA no no up no no no Ribosome Acute myeloid leukemia 0 -0.509881423 -0.453796654 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Acute myeloid leukemia -0.411304348 -0.609683794 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Acute myeloid leukemia 0.502608696 0.759881423 0.587644788 kegg kegg NA NA no no no no no no RNA degradation Acute myeloid leukemia 0 -0.536561265 0 kegg kegg NA NA no no no no no no RNA polymerase Acute myeloid leukemia 0 -0.68972332 0 kegg kegg NA NA no no no no no no RNA transport Acute myeloid leukemia -0.427826087 -0.513833992 -0.546203346 kegg kegg NA NA no no no no no no Sarcina Acute myeloid leukemia 0 0.444554224 0 Genus kegg 0.0703 NA no no no no no no Signaling pathways regulating pluripotency of stem cells Acute myeloid leukemia 0.413913043 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Acute myeloid leukemia 0.527826087 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Acute myeloid leukemia 0.666956522 0.595849802 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Acute myeloid leukemia 0 0.486166008 0.434234234 kegg kegg NA NA no no no no no no Steroid biosynthesis Acute myeloid leukemia -0.412173913 -0.688735178 -0.443243243 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Acute myeloid leukemia -0.569565217 -0.646245059 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Acute myeloid leukemia 0.597391304 0 0.44967825 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Acute myeloid leukemia -0.567826087 -0.732213439 0 kegg kegg NA NA no no no no no no Taste transduction Acute myeloid leukemia 0 -0.688735178 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Acute myeloid leukemia 0 0.459486166 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Acute myeloid leukemia -0.415652174 -0.533596838 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Acute myeloid leukemia 0 -0.578063241 0 kegg kegg NA NA no no no no no no Thermogenesis Acute myeloid leukemia 0 -0.563241107 0 kegg kegg NA NA no no no no no no Thiamine metabolism Acute myeloid leukemia 0 -0.665019763 0 kegg kegg NA NA no no no no no no TNF signaling pathway Acute myeloid leukemia 0.519130435 0.754940711 0.524839125 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Acute myeloid leukemia 0.576521739 0.77173913 0.547747748 yes kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Acute myeloid leukemia 0 0.699604743 0.457142857 kegg kegg NA NA no no no no no no Tryptophan metabolism Acute myeloid leukemia -0.576521739 -0.732213439 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Acute myeloid leukemia 0.724347826 0.755928854 0.737966538 kegg kegg NA NA no no no no no no Tyrosine metabolism Acute myeloid leukemia -0.646086957 -0.774703557 -0.550579151 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Acute myeloid leukemia -0.592173913 -0.769762846 -0.410553411 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Acute myeloid leukemia -0.653043478 -0.838932806 -0.467696268 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Acute myeloid leukemia 0 -0.491106719 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Acute myeloid leukemia 0 -0.480237154 -0.485971686 kegg kegg NA NA no no no no no no VEGF signaling pathway Acute myeloid leukemia 0.650434783 0.751976285 0.406949807 kegg kegg NA NA no no no no no no Viral carcinogenesis Acute myeloid leukemia 0 0.601778656 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Acute myeloid leukemia 0 0 0.527155727 kegg kegg NA NA no no no no no no Wnt signaling pathway Acute myeloid leukemia 0 -0.518774704 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Adherens junction 0 0.42687747 0 kegg kegg NA NA no no no no no no ABC transporters Adherens junction 0 -0.635375494 0 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes Adherens junction 0 0.42687747 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Adherens junction 0 -0.693675889 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Adherens junction 0 -0.5 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Adherens junction -0.415652174 0.5 0 kegg kegg NA NA no no no no no no Apoptosis Adherens junction 0.473043478 0 0.458429858 kegg kegg NA NA no no no no no no Apoptosis - multiple species Adherens junction -0.746086957 -0.677865613 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Adherens junction 0 -0.574110672 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Adherens junction 0 -0.628458498 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Adherens junction 0 0.43972332 0 kegg kegg NA NA no no no no no no Autophagy - animal Adherens junction -0.734782609 -0.865612648 -0.52020592 kegg kegg NA NA no no no no no no Autophagy - other Adherens junction -0.827826087 -0.7756917 -0.508365508 kegg kegg NA NA no no no no no no Basal transcription factors Adherens junction -0.71826087 0 0 kegg kegg NA NA no no no no no no Base excision repair Adherens junction -0.680869565 0 0 kegg kegg NA NA no no no no no no Bifidobacterium Adherens junction 0 0.497277404 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Butanoate metabolism Adherens junction 0 0.445652174 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Adherens junction 0 0.473320158 0 kegg kegg NA NA no up up no no no Carbon metabolism Adherens junction 0 0.443675889 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Adherens junction 0 0.690711462 0.596653797 kegg kegg NA NA no no up no no no Citrate cycle (TCA cycle) Adherens junction 0 0.471343874 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Adherens junction 0 0 0.603346203 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Adherens junction 0 0.608695652 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Adherens junction 0 0.719367589 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Adherens junction -0.436521739 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Adherens junction -0.419130435 -0.549407115 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Adherens junction -0.406956522 0 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Adherens junction 0 -0.599802372 0 kegg kegg NA NA no no no no no no Fatty acid degradation Adherens junction 0 -0.625494071 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Adherens junction 0 -0.550395257 0 kegg kegg NA NA no no no no no no Focal adhesion Adherens junction 0.88 0.938735178 0.893436293 kegg kegg NA NA no up up no no no Folate biosynthesis Adherens junction 0 0.434782609 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Adherens junction -0.49826087 -0.78458498 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Adherens junction 0 -0.462450593 0 kegg kegg NA NA no no no no no no Glutathione metabolism Adherens junction 0 0.425889328 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Adherens junction 0 -0.647233202 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Adherens junction -0.477391304 -0.675889328 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Adherens junction 0 0.611660079 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Adherens junction 0 -0.672924901 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Adherens junction 0.53826087 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Adherens junction -0.420869565 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Adherens junction 0 -0.621541502 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Adherens junction -0.562608696 0.479249012 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Adherens junction 0.914782609 0.924901186 0.918404118 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Adherens junction 0 -0.545454545 0 kegg kegg NA NA no no no no no no Homologous recombination Adherens junction -0.422608696 -0.501976285 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Adherens junction 0 -0.631422925 0 kegg kegg NA NA no no no no no no Lachnospira Adherens junction 0 0.618729942 -0.420103442 butyrate-producing Genus kegg 0.279 NA no no no no no no Longevity regulating pathway Adherens junction 0 -0.541501976 0 kegg kegg NA NA no no no no no no Lysine degradation Adherens junction -0.480869565 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Adherens junction 0 -0.675889328 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Adherens junction 0 0.651185771 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Adherens junction -0.422608696 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Adherens junction 0 -0.650197628 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Adherens junction 0 0.457509881 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Adherens junction -0.430434783 -0.75 -0.575289575 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Adherens junction 0 -0.511857708 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Adherens junction 0 -0.621541502 0 kegg kegg NA NA no no no no no no Oocyte meiosis Adherens junction 0 0.425889328 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Adherens junction 0 -0.463438735 0 kegg kegg NA NA no no no no no no Other glycan degradation Adherens junction 0 -0.500988142 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Adherens junction -0.493913043 -0.434782609 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Adherens junction 0 0.690711462 0.604118404 kegg kegg NA NA no no no no no no p53 signaling pathway Adherens junction -0.792173913 -0.691699605 -0.473616474 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Adherens junction 0 -0.510869565 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Adherens junction 0 0.473320158 0 kegg kegg NA NA no no no no no no Peroxisome Adherens junction 0 -0.56916996 0 kegg kegg NA NA no no no no no no Phagosome Adherens junction 0.43826087 0 0.413899614 kegg kegg NA NA no no no no no no Phenylalanine metabolism Adherens junction 0.613913043 0.613636364 0.573487773 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Adherens junction 0 -0.489130435 0 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Adherens junction -0.451304348 0 0 yes kegg kegg NA NA no up up no no no Platinum drug resistance Adherens junction -0.789565217 -0.621541502 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Adherens junction 0 -0.523715415 0 kegg kegg NA NA no no no no no no Proteasome Adherens junction -0.482608696 0.537549407 0 kegg kegg NA NA no no no no no no Protein export Adherens junction -0.506956522 0.568181818 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Adherens junction 0 0 -0.416473616 kegg kegg NA NA no no no no no no Pyruvate metabolism Adherens junction 0 0.416996047 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Adherens junction 0.892173913 0.873517787 0.848391248 kegg kegg NA NA no no no no no no Ras signaling pathway Adherens junction 0 0.564229249 0 yes kegg kegg NA NA no up up no no no Ribosome Adherens junction 0 0.562252964 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Adherens junction -0.580869565 0 0 kegg kegg NA NA no no no no no no RNA polymerase Adherens junction -0.688695652 0 0 kegg kegg NA NA no no no no no no RNA transport Adherens junction -0.416521739 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Adherens junction -0.710434783 -0.477272727 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Adherens junction 0 -0.701581028 0 kegg kegg NA NA no no no no no no Spliceosome Adherens junction -0.788695652 -0.622529644 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Adherens junction 0 -0.528656126 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Adherens junction -0.422608696 -0.649209486 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Adherens junction -0.476521739 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Adherens junction 0 0.549407115 0 kegg kegg NA NA no no no no no no Thiamine metabolism Adherens junction 0 0 -0.47979408 kegg kegg NA NA no no no no no no Tyrosine metabolism Adherens junction 0 0.462450593 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Adherens junction -0.524347826 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Adherens junction 0 0.693675889 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Adherens junction 0 0 0.423938224 kegg kegg NA NA no no no no no no Wnt signaling pathway Adherens junction 0 0.481225296 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Adipocytokine signaling pathway 0 -0.556324111 -0.655598456 kegg kegg NA NA no no no no no no Adherens junction Adipocytokine signaling pathway 0 -0.59486166 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Adipocytokine signaling pathway 0 0.519762846 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Adipocytokine signaling pathway 0 0 -0.574517375 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Adipocytokine signaling pathway -0.525217391 -0.459486166 -0.404118404 kegg kegg NA NA no no no no no no AMPK signaling pathway Adipocytokine signaling pathway 0.467826087 0 0.834749035 kegg kegg NA NA no no no no no no Apelin signaling pathway Adipocytokine signaling pathway 0 -0.432806324 0 kegg kegg NA NA no no no no no no Apoptosis Adipocytokine signaling pathway 0 0.431818182 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Adipocytokine signaling pathway 0 0.468379447 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Adipocytokine signaling pathway 0 0.536561265 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Adipocytokine signaling pathway -0.413043478 -0.523715415 -0.480566281 kegg kegg NA NA no no no no no no Autophagy - animal Adipocytokine signaling pathway 0 0.666996047 0 kegg kegg NA NA no no no no no no Autophagy - other Adipocytokine signaling pathway 0 0.422924901 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Adipocytokine signaling pathway 0 0.568181818 0 kegg kegg NA NA no no no no no no Basal transcription factors Adipocytokine signaling pathway -0.427826087 0 0 kegg kegg NA NA no no no no no no Base excision repair Adipocytokine signaling pathway -0.48173913 0 -0.503732304 kegg kegg NA NA no no no no no no beta-Alanine metabolism Adipocytokine signaling pathway 0 -0.730237154 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Adipocytokine signaling pathway 0 0 0.683912484 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Adipocytokine signaling pathway -0.740869565 -0.548418972 -0.526383526 kegg kegg NA NA no no no no no no Butanoate metabolism Adipocytokine signaling pathway -0.424347826 -0.701581028 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Adipocytokine signaling pathway 0 0.631422925 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Adipocytokine signaling pathway 0 0.755928854 0.534362934 yes kegg kegg NA NA no up up no no no Carbon metabolism Adipocytokine signaling pathway 0 -0.483201581 0 kegg kegg NA NA no no no no no no Cell cycle Adipocytokine signaling pathway -0.67826087 0 0 kegg kegg NA NA no no no no no no Circadian entrainment Adipocytokine signaling pathway 0 -0.516798419 0 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Adipocytokine signaling pathway -0.616521739 -0.707509881 -0.64993565 kegg kegg NA NA no no no no no no Clostridium Adipocytokine signaling pathway -0.452707121 -0.459481269 0 Genus kegg 0.925 NA no no no no no no Cysteine and methionine metabolism Adipocytokine signaling pathway -0.649565217 -0.699604743 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Adipocytokine signaling pathway 0.482608696 0.799407115 0 kegg kegg NA NA no no no no no no DNA replication Adipocytokine signaling pathway -0.68173913 -0.67687747 -0.492921493 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Adipocytokine signaling pathway 0 -0.722332016 -0.548777349 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Adipocytokine signaling pathway 0 -0.645256917 -0.413384813 kegg kegg NA NA no no no no no no ECM-receptor interaction Adipocytokine signaling pathway -0.426956522 0 0 kegg kegg NA NA no up up no no no Endocrine resistance Adipocytokine signaling pathway 0 0 0.437065637 kegg kegg NA NA no no no no no no Estrogen signaling pathway Adipocytokine signaling pathway -0.652173913 -0.590909091 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Adipocytokine signaling pathway -0.69826087 0 -0.478764479 kegg kegg NA NA no no no no no no Fatty acid elongation Adipocytokine signaling pathway -0.632173913 -0.679841897 -0.527155727 kegg kegg NA NA no no no no no no Fatty acid metabolism Adipocytokine signaling pathway -0.459130435 0 -0.411325611 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Adipocytokine signaling pathway 0 0.456521739 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Adipocytokine signaling pathway -0.413913043 0 0 kegg kegg NA NA no no no no no no Ferroptosis Adipocytokine signaling pathway 0.56 0.528656126 0.729214929 kegg kegg NA NA no no no no no no Focal adhesion Adipocytokine signaling pathway 0 -0.674901186 0 kegg kegg NA NA no up up no no no Gap junction Adipocytokine signaling pathway 0 0 0.426254826 kegg kegg NA NA no no no no no no Glutamatergic synapse Adipocytokine signaling pathway 0 0.456521739 0.4996139 kegg kegg NA NA no up up no no no Glutathione metabolism Adipocytokine signaling pathway 0 0 0.51994852 kegg kegg NA NA no no no no no no Glycerolipid metabolism Adipocytokine signaling pathway 0 0 -0.438610039 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Adipocytokine signaling pathway 0 0 -0.408494208 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Adipocytokine signaling pathway 0 0 0.761132561 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Adipocytokine signaling pathway 0 -0.619565217 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Adipocytokine signaling pathway 0 0.572134387 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Adipocytokine signaling pathway 0 -0.490118577 -0.554182754 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Adipocytokine signaling pathway 0 0 -0.562676963 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - globo and isoglobo series Adipocytokine signaling pathway 0 0 0.413384813 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Adipocytokine signaling pathway 0 0.520750988 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Adipocytokine signaling pathway 0 -0.708498024 -0.407979408 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Adipocytokine signaling pathway 0 -0.424901186 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Adipocytokine signaling pathway 0 -0.636363636 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Adipocytokine signaling pathway 0 0 -0.442471042 kegg kegg NA NA no no no no no no Homologous recombination Adipocytokine signaling pathway -0.673913043 0 0 kegg kegg NA NA no no no no no no Insulin secretion Adipocytokine signaling pathway 0 0 0.443758044 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Adipocytokine signaling pathway 0 -0.421936759 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Adipocytokine signaling pathway 0 0.479249012 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Adipocytokine signaling pathway 0 -0.416007905 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Adipocytokine signaling pathway 0 -0.414031621 0 kegg kegg NA NA no no no no no no Long-term depression Adipocytokine signaling pathway 0 0.42687747 0.466409266 kegg kegg NA NA no no no no no no Long-term potentiation Adipocytokine signaling pathway 0 -0.482213439 -0.451222651 kegg kegg NA NA no no up no no no Longevity regulating pathway Adipocytokine signaling pathway 0.633043478 0.732213439 0.901930502 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Adipocytokine signaling pathway -0.773043478 -0.422924901 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Adipocytokine signaling pathway -0.439130435 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Adipocytokine signaling pathway 0 -0.769762846 -0.544916345 kegg kegg NA NA no no no no no no Mismatch repair Adipocytokine signaling pathway -0.748695652 -0.654150198 -0.471814672 kegg kegg NA NA no no no no no no Mitophagy - animal Adipocytokine signaling pathway 0.615652174 0 0.643243243 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Adipocytokine signaling pathway -0.629565217 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Adipocytokine signaling pathway -0.446086957 -0.530632411 0 kegg kegg NA NA no no no no no no Necroptosis Adipocytokine signaling pathway 0.517391304 0.450592885 0.649420849 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Adipocytokine signaling pathway 0 0.653162055 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Adipocytokine signaling pathway 0 0.707509881 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Adipocytokine signaling pathway 0 0.599802372 0.506048906 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Adipocytokine signaling pathway 0 0.54743083 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Adipocytokine signaling pathway -0.606086957 -0.721343874 0 kegg kegg NA NA no no no no no no Notch signaling pathway Adipocytokine signaling pathway 0 0 -0.454568855 kegg kegg NA NA no no no no no no Nucleotide excision repair Adipocytokine signaling pathway -0.725217391 -0.579051383 0 kegg kegg NA NA no no no no no no One carbon pool by folate Adipocytokine signaling pathway -0.688695652 -0.610671937 -0.486486486 kegg kegg NA NA no no no no no no Oocyte meiosis Adipocytokine signaling pathway -0.486956522 -0.635375494 -0.482882883 kegg kegg NA NA no no no no no no Other glycan degradation Adipocytokine signaling pathway 0 0 -0.622651223 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Adipocytokine signaling pathway 0 0 0.477477477 kegg kegg NA NA no up up no no no Paraprevotella Adipocytokine signaling pathway 0 -0.428393477 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Adipocytokine signaling pathway -0.577391304 -0.621541502 -0.667696268 kegg kegg NA NA no no no no no no Phenylalanine metabolism Adipocytokine signaling pathway 0 -0.761857708 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Adipocytokine signaling pathway 0 0.600790514 0 kegg kegg NA NA no up up no no no Phototransduction Adipocytokine signaling pathway 0 -0.604743083 -0.462548263 kegg kegg NA NA no no no no no no Platelet activation Adipocytokine signaling pathway 0 -0.522727273 0 kegg kegg NA NA no no no no no no Platinum drug resistance Adipocytokine signaling pathway -0.405217391 0 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Adipocytokine signaling pathway 0 0 0.758558559 kegg kegg NA NA no no no no no no PPAR signaling pathway Adipocytokine signaling pathway 0 0.589920949 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Adipocytokine signaling pathway -0.726956522 -0.608695652 -0.427284427 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Adipocytokine signaling pathway 0 0 -0.543886744 kegg kegg NA NA no no no no no no Prolactin signaling pathway Adipocytokine signaling pathway 0 0.484189723 0 kegg kegg NA NA no no no no no no Propanoate metabolism Adipocytokine signaling pathway -0.620869565 -0.670948617 0 kegg kegg NA NA no no no no no no Proteasome Adipocytokine signaling pathway 0 -0.529644269 -0.402831403 kegg kegg NA NA no no no no no no Protein export Adipocytokine signaling pathway 0 -0.446640316 0 kegg kegg NA NA no no no no no no Purine metabolism Adipocytokine signaling pathway 0 0 0.745173745 kegg kegg NA NA no no no no no no Pyrimidine metabolism Adipocytokine signaling pathway -0.417391304 -0.541501976 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Adipocytokine signaling pathway -0.645217391 -0.604743083 0 kegg kegg NA NA no no no no no no Ras signaling pathway Adipocytokine signaling pathway 0 -0.596837945 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Adipocytokine signaling pathway 0 -0.638339921 0 kegg kegg NA NA no no no no no no Retinol metabolism Adipocytokine signaling pathway -0.642608696 -0.630434783 -0.634234234 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Adipocytokine signaling pathway 0 0 -0.523552124 kegg kegg NA NA no no up no no no Ribosome biogenesis in eukaryotes Adipocytokine signaling pathway -0.46 -0.419960474 -0.464350064 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Adipocytokine signaling pathway 0 0.747035573 0 kegg kegg NA NA no no no no no no RNA degradation Adipocytokine signaling pathway 0 -0.416007905 0 kegg kegg NA NA no no no no no no RNA polymerase Adipocytokine signaling pathway 0 -0.414031621 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Adipocytokine signaling pathway 0 0 -0.476447876 kegg kegg NA NA no no no no no no Serotonergic synapse Adipocytokine signaling pathway 0 0 0.406435006 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Adipocytokine signaling pathway 0 0 -0.413642214 kegg kegg NA NA no no no no no no Sphingolipid metabolism Adipocytokine signaling pathway 0.431304348 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Adipocytokine signaling pathway 0 0 -0.448906049 kegg kegg NA NA no no no no no no Steroid biosynthesis Adipocytokine signaling pathway -0.406086957 -0.685770751 -0.506048906 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Adipocytokine signaling pathway -0.424347826 -0.709486166 -0.478507079 kegg kegg NA NA no no no no no no Sulfur metabolism Adipocytokine signaling pathway 0 0 0.548777349 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Adipocytokine signaling pathway -0.780869565 -0.524703557 -0.505534106 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Adipocytokine signaling pathway 0 0.527667984 0 kegg kegg NA NA no no no no no no Taste transduction Adipocytokine signaling pathway -0.606956522 -0.480237154 -0.472329472 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Adipocytokine signaling pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Adipocytokine signaling pathway -0.531304348 0 -0.408751609 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Adipocytokine signaling pathway 0 -0.5 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Adipocytokine signaling pathway 0.41826087 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Adipocytokine signaling pathway 0 -0.445652174 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Adipocytokine signaling pathway 0 0 0.550579151 kegg kegg NA NA no no no no no no Tight junction Adipocytokine signaling pathway 0 -0.497035573 0 kegg kegg NA NA no no no no no no TNF signaling pathway Adipocytokine signaling pathway 0.523478261 0.72826087 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Adipocytokine signaling pathway 0 0.637351779 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Adipocytokine signaling pathway -0.509565217 -0.783596838 -0.447361647 kegg kegg NA NA no up no no no no Tyrosine metabolism Adipocytokine signaling pathway -0.519130435 -0.734189723 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Adipocytokine signaling pathway -0.553043478 -0.651185771 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Adipocytokine signaling pathway 0.500869565 0 0.616988417 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Adipocytokine signaling pathway -0.589565217 -0.691699605 -0.570656371 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Adipocytokine signaling pathway 0 -0.431818182 -0.523809524 kegg kegg NA NA no no no no no no Wnt signaling pathway Adipocytokine signaling pathway 0 -0.484189723 -0.41003861 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Adrenergic signaling in cardiomyocytes -0.586956522 0 0 kegg kegg NA NA no no no no no up ABC transporters Adrenergic signaling in cardiomyocytes -0.736521739 0 0 kegg kegg NA NA no up up no no up "Alanine, aspartate and glutamate metabolism" Adrenergic signaling in cardiomyocytes -0.48 -0.690711462 -0.546203346 kegg kegg NA NA no no no no no up alpha-Linolenic acid metabolism Adrenergic signaling in cardiomyocytes -0.766086957 -0.760869565 -0.568339768 kegg kegg NA NA no no no no no up Amino sugar and nucleotide sugar metabolism Adrenergic signaling in cardiomyocytes -0.692173913 0 -0.545688546 kegg kegg NA NA no no no no no up Aminoacyl-tRNA biosynthesis Adrenergic signaling in cardiomyocytes -0.628695652 0 0 kegg kegg NA NA no no no no no up AMPK signaling pathway Adrenergic signaling in cardiomyocytes 0 0.64229249 0 kegg kegg NA NA no no no no no up Apoptosis Adrenergic signaling in cardiomyocytes -0.504347826 -0.545454545 -0.515830116 kegg kegg NA NA no no no no no up Arginine and proline metabolism Adrenergic signaling in cardiomyocytes -0.473043478 -0.640316206 -0.450707851 kegg kegg NA NA no up no no no up Arginine biosynthesis Adrenergic signaling in cardiomyocytes -0.503478261 -0.639328063 -0.523294723 kegg kegg NA NA no no no no no up Ascorbate and aldarate metabolism Adrenergic signaling in cardiomyocytes -0.442608696 0 0 kegg kegg NA NA no no no no no up Autophagy - animal Adrenergic signaling in cardiomyocytes 0 -0.508893281 0 kegg kegg NA NA no no no no no up beta-Alanine metabolism Adrenergic signaling in cardiomyocytes -0.783478261 0 -0.463320463 kegg kegg NA NA no no no no no up Biosynthesis of amino acids Adrenergic signaling in cardiomyocytes -0.677391304 -0.669960474 -0.647619048 kegg kegg NA NA no no no no no up Biosynthesis of cofactors Adrenergic signaling in cardiomyocytes 0 0.462450593 0 kegg kegg NA NA no no no no no up Biosynthesis of unsaturated fatty acids Adrenergic signaling in cardiomyocytes -0.471304348 0 0 kegg kegg NA NA no no no no no up Butanoate metabolism Adrenergic signaling in cardiomyocytes -0.666086957 0 0 kegg kegg NA NA no no no no no up Butyricimonas Adrenergic signaling in cardiomyocytes 0.549552113 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no up Calcium signaling pathway Adrenergic signaling in cardiomyocytes 0.857391304 0.798418972 0.83963964 kegg kegg NA NA no up up no no up cAMP signaling pathway Adrenergic signaling in cardiomyocytes 0.832173913 0 0.550836551 yes kegg kegg NA NA no up up no no up Carbon metabolism Adrenergic signaling in cardiomyocytes -0.654782609 0 -0.655855856 kegg kegg NA NA no no no no no up Cardiac muscle contraction Adrenergic signaling in cardiomyocytes 0.729565217 0.779644269 0.458944659 kegg kegg NA NA no no up no no up Cell cycle Adrenergic signaling in cardiomyocytes 0 0.453557312 0.492921493 kegg kegg NA NA no no no no no up Cellular senescence Adrenergic signaling in cardiomyocytes 0 -0.455533597 0 kegg kegg NA NA no no no no no up cGMP-PKG signaling pathway Adrenergic signaling in cardiomyocytes 0 -0.657114625 0 kegg kegg NA NA no no no no no up Chemokine signaling pathway Adrenergic signaling in cardiomyocytes 0 -0.47826087 0 kegg kegg NA NA no no no no no up Citrate cycle (TCA cycle) Adrenergic signaling in cardiomyocytes -0.425217391 0 0 kegg kegg NA NA no no no no no up Clostridium Adrenergic signaling in cardiomyocytes -0.426969045 0 0 Genus kegg 0.925 NA no no no no no up Cytokine-cytokine receptor interaction Adrenergic signaling in cardiomyocytes 0 -0.565217391 0 kegg kegg NA NA no no no no no up Drug metabolism - other enzymes Adrenergic signaling in cardiomyocytes -0.589565217 0 -0.526383526 kegg kegg NA NA no no no no no up EGFR tyrosine kinase inhibitor resistance Adrenergic signaling in cardiomyocytes 0 0.613636364 0 kegg kegg NA NA no no no no no up Endocrine resistance Adrenergic signaling in cardiomyocytes 0.635652174 0 0.557528958 kegg kegg NA NA no no no no no up Endocytosis Adrenergic signaling in cardiomyocytes 0 -0.530632411 0 kegg kegg NA NA no no no no no up Ether lipid metabolism Adrenergic signaling in cardiomyocytes 0.430434783 0.520750988 0 kegg kegg NA NA no no no no no up Fatty acid biosynthesis Adrenergic signaling in cardiomyocytes 0 -0.748023715 -0.502187902 kegg kegg NA NA no no no no no up Fatty acid degradation Adrenergic signaling in cardiomyocytes -0.677391304 -0.703557312 -0.648133848 kegg kegg NA NA no no no no no up Fatty acid elongation Adrenergic signaling in cardiomyocytes -0.567826087 0 0 kegg kegg NA NA no no no no no up Fatty acid metabolism Adrenergic signaling in cardiomyocytes -0.766956522 -0.766798419 -0.58018018 kegg kegg NA NA no no no no no up Ferroptosis Adrenergic signaling in cardiomyocytes 0.42 0 0 kegg kegg NA NA no no no no no up Folate biosynthesis Adrenergic signaling in cardiomyocytes 0 0.447628458 0 kegg kegg NA NA no no no no no up FoxO signaling pathway Adrenergic signaling in cardiomyocytes 0 -0.580039526 0 kegg kegg NA NA no no no no no up Fructose and mannose metabolism Adrenergic signaling in cardiomyocytes -0.836521739 0 -0.695238095 kegg kegg NA NA no no no no no up Galactose metabolism Adrenergic signaling in cardiomyocytes -0.910434783 -0.781620553 -0.539253539 kegg kegg NA NA no no no no no up Glutathione metabolism Adrenergic signaling in cardiomyocytes 0 0.632411067 0 kegg kegg NA NA no no no no no up Glycerolipid metabolism Adrenergic signaling in cardiomyocytes -0.622608696 -0.433794466 0 kegg kegg NA NA no no up no no up "Glycine, serine and threonine metabolism" Adrenergic signaling in cardiomyocytes 0 0.469367589 0 kegg kegg NA NA no up no no no up Glycolysis / Gluconeogenesis Adrenergic signaling in cardiomyocytes -0.568695652 0 0 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Adrenergic signaling in cardiomyocytes 0 -0.472332016 0 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - keratan sulfate Adrenergic signaling in cardiomyocytes 0.506086957 0.451581028 0.485199485 kegg kegg NA NA no no no no no up Glycosaminoglycan degradation Adrenergic signaling in cardiomyocytes 0 -0.499011858 0 kegg kegg NA NA no no up no no up Glyoxylate and dicarboxylate metabolism Adrenergic signaling in cardiomyocytes -0.686086957 -0.65513834 -0.588931789 kegg kegg NA NA no no no no no up HIF-1 signaling pathway Adrenergic signaling in cardiomyocytes 0 0.485177866 0 kegg kegg NA NA no no no no no up Histidine metabolism Adrenergic signaling in cardiomyocytes -0.730434783 0 -0.635521236 kegg kegg NA NA no no no no no up Inositol phosphate metabolism Adrenergic signaling in cardiomyocytes -0.508695652 0 0 kegg kegg NA NA no no no no no up Longevity regulating pathway - multiple species Adrenergic signaling in cardiomyocytes 0 -0.491106719 0 kegg kegg NA NA no no no no no up Lysosome Adrenergic signaling in cardiomyocytes 0 -0.522727273 -0.646846847 kegg kegg NA NA no no no no no up MAPK signaling pathway Adrenergic signaling in cardiomyocytes 0 -0.498023715 0 kegg kegg NA NA no no no no no up Mitophagy - animal Adrenergic signaling in cardiomyocytes 0.624347826 0.716403162 0 kegg kegg NA NA no no no no no up mRNA surveillance pathway Adrenergic signaling in cardiomyocytes 0.589565217 0.766798419 0.588159588 kegg kegg NA NA no no no no no up mTOR signaling pathway Adrenergic signaling in cardiomyocytes 0 0.606719368 0 kegg kegg NA NA no no no no no up N-Glycan biosynthesis Adrenergic signaling in cardiomyocytes 0 0.586956522 0 kegg kegg NA NA no no no no no up Necroptosis Adrenergic signaling in cardiomyocytes 0.537391304 0 0 kegg kegg NA NA no no no no no up Neuroactive ligand-receptor interaction Adrenergic signaling in cardiomyocytes 0 -0.639328063 -0.494723295 kegg kegg NA NA up up up no no up NF-kappa B signaling pathway Adrenergic signaling in cardiomyocytes -0.447826087 -0.529644269 0 kegg kegg NA NA no no no no no up Nicotinate and nicotinamide metabolism Adrenergic signaling in cardiomyocytes -0.405217391 -0.673913043 -0.559073359 kegg kegg NA NA no no no no no up Nitrogen metabolism Adrenergic signaling in cardiomyocytes 0 -0.509881423 0 kegg kegg NA NA no no no no no up Non-homologous end-joining Adrenergic signaling in cardiomyocytes -0.566086957 0 0 kegg kegg NA NA no no no no no up Oocyte meiosis Adrenergic signaling in cardiomyocytes 0.483478261 0 0.558301158 kegg kegg NA NA no no no no no up Oscillospira Adrenergic signaling in cardiomyocytes 0 0 -0.441698842 LPS-producing Genus kegg 0.62 NA no no no no no up Other glycan degradation Adrenergic signaling in cardiomyocytes -0.612173913 0 0 kegg kegg NA NA no no no no no up Oxidative phosphorylation Adrenergic signaling in cardiomyocytes 0.713043478 0.793478261 0.401544402 kegg kegg NA NA no no no no no up Pantothenate and CoA biosynthesis Adrenergic signaling in cardiomyocytes 0 -0.833003953 -0.665894466 kegg kegg NA NA no no dn no no up Pentose and glucuronate interconversions Adrenergic signaling in cardiomyocytes 0 0.428853755 0 kegg kegg NA NA no no no no no up Pentose phosphate pathway Adrenergic signaling in cardiomyocytes -0.509565217 -0.675889328 -0.703989704 kegg kegg NA NA no no no no no up Peroxisome Adrenergic signaling in cardiomyocytes -0.596521739 -0.842885375 -0.583268983 kegg kegg NA NA no no no no no up Phagosome Adrenergic signaling in cardiomyocytes 0 -0.593873518 -0.415186615 kegg kegg NA NA no no no no no up Phenylalanine metabolism Adrenergic signaling in cardiomyocytes -0.41826087 0 0 kegg kegg NA NA no no no no no up Phosphatidylinositol signaling system Adrenergic signaling in cardiomyocytes 0.553043478 0 0 kegg kegg NA NA no no no no no up PPAR signaling pathway Adrenergic signaling in cardiomyocytes 0 -0.56916996 0 kegg kegg NA NA no no no no no up Prevotella Adrenergic signaling in cardiomyocytes 0 0 0.433147007 acetate-producing Genus kegg 0.287 NA no no no no no up Primary bile acid biosynthesis Adrenergic signaling in cardiomyocytes -0.505217391 0 0 kegg kegg NA NA no no no no no up Protein export Adrenergic signaling in cardiomyocytes 0.500869565 0.646245059 0.476962677 kegg kegg NA NA no no no no no up Protein processing in endoplasmic reticulum Adrenergic signaling in cardiomyocytes 0 0.66798419 0 kegg kegg NA NA no no no no no up Purine metabolism Adrenergic signaling in cardiomyocytes 0 0.48715415 0 kegg kegg NA NA no no no no no up Pyrimidine metabolism Adrenergic signaling in cardiomyocytes -0.723478261 0 0 kegg kegg NA NA no no no no no up Ras signaling pathway Adrenergic signaling in cardiomyocytes 0.482608696 0.596837945 0.463577864 yes kegg kegg NA NA no up up no no up Retinol metabolism Adrenergic signaling in cardiomyocytes -0.443478261 0 0 kegg kegg NA NA no no no no no up Ribosome Adrenergic signaling in cardiomyocytes 0.599130435 0.706521739 0 kegg kegg NA NA no no no no no up RNA degradation Adrenergic signaling in cardiomyocytes 0.55826087 0.68083004 0.418532819 kegg kegg NA NA no no no no no up RNA polymerase Adrenergic signaling in cardiomyocytes 0 0.516798419 0 kegg kegg NA NA no no no no no up RNA transport Adrenergic signaling in cardiomyocytes 0 0.501976285 0 kegg kegg NA NA no no no no no up SNARE interactions in vesicular transport Adrenergic signaling in cardiomyocytes -0.53826087 -0.453557312 0 kegg kegg NA NA no no no no no up Sphingolipid metabolism Adrenergic signaling in cardiomyocytes 0 0 -0.413127413 kegg kegg NA NA no no no no no up Sphingolipid signaling pathway Adrenergic signaling in cardiomyocytes 0.559130435 0 0 kegg kegg NA NA no no no no no up Spliceosome Adrenergic signaling in cardiomyocytes 0 0 0.408751609 kegg kegg NA NA no no no no no up Starch and sucrose metabolism Adrenergic signaling in cardiomyocytes -0.689565217 -0.801383399 -0.723809524 kegg kegg NA NA no no no no no up Thiamine metabolism Adrenergic signaling in cardiomyocytes -0.443478261 0 0 kegg kegg NA NA no no no no no up Tryptophan metabolism Adrenergic signaling in cardiomyocytes -0.7 0 0 kegg kegg NA NA no up no no no up Ubiquinone and other terpenoid-quinone biosynthesis Adrenergic signaling in cardiomyocytes -0.635652174 0 0 kegg kegg NA NA no no no no no up Ubiquitin mediated proteolysis Adrenergic signaling in cardiomyocytes 0.610434783 0.751976285 0 kegg kegg NA NA no no no no no up "Valine, leucine and isoleucine degradation" Adrenergic signaling in cardiomyocytes -0.597391304 0 0 kegg kegg NA NA no no no no no up Various types of N-glycan biosynthesis Adrenergic signaling in cardiomyocytes 0 0.443675889 0 kegg kegg NA NA no no no no no up Viral protein interaction with cytokine and cytokine receptor Adrenergic signaling in cardiomyocytes 0.462608696 0 0 kegg kegg NA NA no no no no no up 2-Oxocarboxylic acid metabolism African trypanosomiasis -0.553043478 -0.484189723 0 kegg kegg NA NA no no no no no no ABC transporters African trypanosomiasis 0 0.436758893 0 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes African trypanosomiasis 0 -0.561264822 -0.546718147 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications African trypanosomiasis 0 0.606719368 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" African trypanosomiasis 0 0.555335968 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion African trypanosomiasis 0 0 -0.431660232 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism African trypanosomiasis 0 0.746047431 0 kegg kegg NA NA no no no no no no Alzheimer disease African trypanosomiasis 0 -0.482213439 0 kegg kegg NA NA no no no no no no Amphetamine addiction African trypanosomiasis 0 -0.462450593 -0.454311454 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis African trypanosomiasis 0 -0.480237154 0 kegg kegg NA NA no no no no no no Apelin signaling pathway African trypanosomiasis 0 -0.722332016 0 kegg kegg NA NA no no no no no no Apoptosis African trypanosomiasis 0 0.516798419 0 kegg kegg NA NA no no no no no no Arginine biosynthesis African trypanosomiasis 0 0.566205534 0 kegg kegg NA NA no no no no no no Autophagy - animal African trypanosomiasis 0 0.458498024 0 kegg kegg NA NA no no no no no no Axon guidance African trypanosomiasis 0 0 -0.414157014 kegg kegg NA NA no up up no no no B cell receptor signaling pathway African trypanosomiasis 0 0.436758893 0.421364221 kegg kegg NA NA no no no no no no Butanoate metabolism African trypanosomiasis -0.423478261 -0.540513834 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway African trypanosomiasis 0.484347826 0.520750988 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption African trypanosomiasis 0 0.453557312 0 kegg kegg NA NA no no no no no no Carbon metabolism African trypanosomiasis -0.444347826 0 0 kegg kegg NA NA no no no no no no Cellular senescence African trypanosomiasis 0 0.459486166 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway African trypanosomiasis 0.466956522 0 0 kegg kegg NA NA no no no no no no Chagas disease African trypanosomiasis 0 0.561264822 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway African trypanosomiasis 0 0.471343874 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) African trypanosomiasis -0.533043478 -0.568181818 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades African trypanosomiasis 0 0.529644269 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism African trypanosomiasis 0 -0.58201581 0 kegg kegg NA NA no no no no no no DNA replication African trypanosomiasis 0 -0.476284585 0 kegg kegg NA NA no no no no no no Dopaminergic synapse African trypanosomiasis 0 -0.472332016 -0.442471042 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 African trypanosomiasis 0 -0.595849802 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes African trypanosomiasis -0.407826087 -0.636363636 0.421621622 kegg kegg NA NA no no no no no no ECM-receptor interaction African trypanosomiasis 0 -0.459486166 -0.522779923 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance African trypanosomiasis 0 -0.716403162 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection African trypanosomiasis 0 0.508893281 0 kegg kegg NA NA no no no no no no ErbB signaling pathway African trypanosomiasis 0.427826087 0 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway African trypanosomiasis 0 0 -0.476447876 kegg kegg NA NA no no no no no no Fat digestion and absorption African trypanosomiasis 0 0.556324111 0.548005148 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis African trypanosomiasis 0 0.603754941 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway African trypanosomiasis 0.482608696 0.62055336 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis African trypanosomiasis 0 0.497035573 0 kegg kegg NA NA no no no no no no Folate biosynthesis African trypanosomiasis 0 -0.581027668 0 kegg kegg NA NA no no no no no no FoxO signaling pathway African trypanosomiasis 0 0.553359684 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism African trypanosomiasis 0 0 0.561904762 kegg kegg NA NA no no no no no no GABAergic synapse African trypanosomiasis 0 0.431818182 0 kegg kegg NA NA no up up no no no Galactose metabolism African trypanosomiasis 0 0.631422925 0.417503218 kegg kegg NA NA no no no no no no Glucagon signaling pathway African trypanosomiasis 0 -0.420948617 -0.514028314 kegg kegg NA NA no no no no no no Glutamatergic synapse African trypanosomiasis 0 0.414031621 0 kegg kegg NA NA no up up no no no Glutathione metabolism African trypanosomiasis 0 -0.632411067 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism African trypanosomiasis 0 0.450592885 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis African trypanosomiasis -0.503478261 -0.503952569 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate African trypanosomiasis 0 0.566205534 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin African trypanosomiasis -0.422608696 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series African trypanosomiasis 0 -0.416007905 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism African trypanosomiasis 0 0.522727273 0 kegg kegg NA NA no no no no no no GnRH secretion African trypanosomiasis 0.523478261 0 0 kegg kegg NA NA no up up no no no GnRH signaling pathway African trypanosomiasis 0 0 -0.414671815 kegg kegg NA NA no no no no no no HIF-1 signaling pathway African trypanosomiasis 0 -0.692687747 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species African trypanosomiasis 0 0.421936759 0 kegg kegg NA NA no no no no no no Huntington disease African trypanosomiasis 0 -0.457509881 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway African trypanosomiasis 0 0.462450593 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels African trypanosomiasis 0 0 -0.472586873 kegg kegg NA NA no no no no no no Insulin resistance African trypanosomiasis 0.473043478 0.509881423 0 kegg kegg NA NA no no no no no no Insulin signaling pathway African trypanosomiasis 0 -0.739130435 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway African trypanosomiasis 0.447826087 0.613636364 0 kegg kegg NA NA no no no no no no Legionellosis African trypanosomiasis 0 -0.529644269 0 kegg kegg NA NA no no no no no no Leishmaniasis African trypanosomiasis 0 -0.483201581 0 kegg kegg NA NA no no no no no no Long-term potentiation African trypanosomiasis 0 -0.545454545 0 kegg kegg NA NA no no up no no no Lysosome African trypanosomiasis 0 0 0.441441441 kegg kegg NA NA no no no no no no Melanogenesis African trypanosomiasis 0 0 -0.527927928 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 African trypanosomiasis 0 -0.559288538 0 kegg kegg NA NA no no no no no no Mismatch repair African trypanosomiasis 0 -0.424901186 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway African trypanosomiasis 0 -0.59486166 0 kegg kegg NA NA no no no no no no mTOR signaling pathway African trypanosomiasis 0 -0.736166008 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis African trypanosomiasis 0 0 -0.426512227 kegg kegg NA NA no no no no no no N-Glycan biosynthesis African trypanosomiasis 0 -0.653162055 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity African trypanosomiasis 0 0.415019763 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation African trypanosomiasis 0 0.558300395 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway African trypanosomiasis 0 0.548418972 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism African trypanosomiasis 0 0.631422925 0 kegg kegg NA NA no no no no no no Nitrogen metabolism African trypanosomiasis 0 0.48715415 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway African trypanosomiasis 0 0.505928854 0 kegg kegg NA NA no no no no no no Non-homologous end-joining African trypanosomiasis -0.455652174 -0.418972332 0 kegg kegg NA NA no no no no no no Notch signaling pathway African trypanosomiasis 0.54 0 0 kegg kegg NA NA no no no no no no Olfactory transduction African trypanosomiasis 0 0.434782609 0 kegg kegg NA NA no no no no no no Oocyte meiosis African trypanosomiasis 0 -0.564229249 -0.411325611 kegg kegg NA NA no no no no no no Osteoclast differentiation African trypanosomiasis 0 0.623517787 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation African trypanosomiasis 0 -0.441699605 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis African trypanosomiasis 0 0.633399209 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" African trypanosomiasis 0 -0.457509881 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions African trypanosomiasis -0.432173913 -0.600790514 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway African trypanosomiasis 0 0.433794466 0 kegg kegg NA NA no no no no no no Peroxisome African trypanosomiasis 0 0.583003953 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism African trypanosomiasis -0.43826087 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway African trypanosomiasis 0 0.601778656 0 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway African trypanosomiasis 0 -0.41798419 0 yes kegg kegg NA NA no up up no no no Prion disease African trypanosomiasis 0 -0.530632411 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway African trypanosomiasis 0.436521739 0.657114625 0 kegg kegg NA NA no no no no no no Propanoate metabolism African trypanosomiasis 0 -0.577075099 0 kegg kegg NA NA no no no no no no Proteasome African trypanosomiasis 0 -0.490118577 0 kegg kegg NA NA no no no no no no Protein export African trypanosomiasis 0 -0.727272727 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum African trypanosomiasis 0 -0.727272727 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation African trypanosomiasis 0 -0.62055336 -0.413642214 kegg kegg NA NA no no no no no no Pyruvate metabolism African trypanosomiasis 0 -0.644268775 0 kegg kegg NA NA no no no no no no Ras signaling pathway African trypanosomiasis 0 -0.589920949 0 yes kegg kegg NA NA no up up no no no Renin secretion African trypanosomiasis 0 0 -0.485714286 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling African trypanosomiasis 0 -0.493083004 0 kegg kegg NA NA no no up no no no Ribosome African trypanosomiasis 0 -0.599802372 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway African trypanosomiasis 0 0.477272727 0 kegg kegg NA NA no no no no no no RNA degradation African trypanosomiasis 0 -0.697628458 0 kegg kegg NA NA no no no no no no RNA polymerase African trypanosomiasis 0 -0.431818182 0 kegg kegg NA NA no no no no no no RNA transport African trypanosomiasis 0 -0.735177866 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway African trypanosomiasis 0.443478261 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism African trypanosomiasis 0 0.631422925 0.5997426 kegg kegg NA NA no no no no no no Synaptic vesicle cycle African trypanosomiasis 0 0.42687747 0.590733591 kegg kegg NA NA no up up no no no Taurine and hypotaurine metabolism African trypanosomiasis 0.430434783 0.422924901 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway African trypanosomiasis 0 -0.647233202 0 kegg kegg NA NA no no no no no no Thermogenesis African trypanosomiasis 0 -0.494071146 0 kegg kegg NA NA no no no no no no Thiamine metabolism African trypanosomiasis 0 -0.636363636 0 kegg kegg NA NA no no no no no no TNF signaling pathway African trypanosomiasis 0 0.440711462 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway African trypanosomiasis 0 0.515810277 0 yes kegg kegg NA NA no no no no no no Type II diabetes mellitus African trypanosomiasis 0.450434783 0.420948617 0 kegg kegg NA NA no no no no no no Tyrosine metabolism African trypanosomiasis -0.440869565 -0.416996047 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" African trypanosomiasis 0 -0.494071146 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis African trypanosomiasis 0 -0.609683794 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption African trypanosomiasis 0 0 -0.40978121 kegg kegg NA NA no no no no no no VEGF signaling pathway African trypanosomiasis 0.499130435 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway African trypanosomiasis 0 -0.551383399 0 kegg kegg NA NA no no no no no no Yersinia infection African trypanosomiasis 0 0.441699605 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism AGE-RAGE signaling pathway in diabetic complications 0 -0.664031621 0 kegg kegg NA NA no no no no no no Adherens junction AGE-RAGE signaling pathway in diabetic complications 0 -0.600790514 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.418972332 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes AGE-RAGE signaling pathway in diabetic complications 0 -0.734189723 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" AGE-RAGE signaling pathway in diabetic complications 0.470434783 0.847826087 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion AGE-RAGE signaling pathway in diabetic complications 0 -0.677865613 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism AGE-RAGE signaling pathway in diabetic complications 0 0.643280632 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis AGE-RAGE signaling pathway in diabetic complications 0 -0.449604743 0 kegg kegg NA NA no no no no no no Apelin signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 -0.799407115 0 kegg kegg NA NA no no no no no no Apoptosis AGE-RAGE signaling pathway in diabetic complications 0 0.725296443 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species AGE-RAGE signaling pathway in diabetic complications 0.546086957 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism AGE-RAGE signaling pathway in diabetic complications -0.462608696 0 -0.494208494 kegg kegg NA NA no no no no no no Arginine and proline metabolism AGE-RAGE signaling pathway in diabetic complications 0 0.85770751 0 kegg kegg NA NA no up no no no no Arginine biosynthesis AGE-RAGE signaling pathway in diabetic complications 0.415652174 0.824110672 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism AGE-RAGE signaling pathway in diabetic complications 0 -0.448616601 0 kegg kegg NA NA no no no no no no Autophagy - animal AGE-RAGE signaling pathway in diabetic complications 0.432173913 0.800395257 0.604890605 kegg kegg NA NA no no no no no no Autophagy - other AGE-RAGE signaling pathway in diabetic complications 0 0 0.415444015 kegg kegg NA NA no no no no no no B cell receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.751976285 0 kegg kegg NA NA no no no no no no Bacteroides AGE-RAGE signaling pathway in diabetic complications 0.451304348 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors AGE-RAGE signaling pathway in diabetic complications 0 -0.434782609 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids AGE-RAGE signaling pathway in diabetic complications 0 0.657114625 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors AGE-RAGE signaling pathway in diabetic complications -0.46 -0.47826087 0 kegg kegg NA NA no no no no no no Butanoate metabolism AGE-RAGE signaling pathway in diabetic complications 0 -0.705533597 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.77173913 0.550579151 kegg kegg NA NA no no no no no no Calcium signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 -0.51284585 0 kegg kegg NA NA no up up no no no Cardiac muscle contraction AGE-RAGE signaling pathway in diabetic complications 0 -0.782608696 0 kegg kegg NA NA no no up no no no Cell cycle AGE-RAGE signaling pathway in diabetic complications 0 -0.566205534 0 kegg kegg NA NA no no no no no no Cellular senescence AGE-RAGE signaling pathway in diabetic complications 0 0.496047431 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.76284585 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.729249012 0 kegg kegg NA NA no no no no no no Cholinergic synapse AGE-RAGE signaling pathway in diabetic complications 0 0.436758893 0 kegg kegg NA NA no no no no no no Circadian entrainment AGE-RAGE signaling pathway in diabetic complications 0 -0.52173913 0 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) AGE-RAGE signaling pathway in diabetic complications 0 -0.748023715 0 kegg kegg NA NA no no no no no no Collinsella AGE-RAGE signaling pathway in diabetic complications 0 0 -0.441821015 Genus kegg 0.128 NA no no no no no no Complement and coagulation cascades AGE-RAGE signaling pathway in diabetic complications 0 0.712450593 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism AGE-RAGE signaling pathway in diabetic complications 0 -0.679841897 0 kegg kegg NA NA no no no no no no DNA replication AGE-RAGE signaling pathway in diabetic complications 0 -0.734189723 0 kegg kegg NA NA no no no no no no Dopaminergic synapse AGE-RAGE signaling pathway in diabetic complications 0 -0.625494071 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 AGE-RAGE signaling pathway in diabetic complications -0.524347826 -0.787549407 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes AGE-RAGE signaling pathway in diabetic complications 0 -0.783596838 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance AGE-RAGE signaling pathway in diabetic complications 0 -0.677865613 0 kegg kegg NA NA no no no no no no Endocytosis AGE-RAGE signaling pathway in diabetic complications 0 0.458498024 0 kegg kegg NA NA no no no no no no ErbB signaling pathway AGE-RAGE signaling pathway in diabetic complications 0.616521739 0.530632411 0.641956242 kegg kegg NA NA no no no no no no Estrogen signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 -0.617588933 0 kegg kegg NA NA no no no no no no Ether lipid metabolism AGE-RAGE signaling pathway in diabetic complications 0 -0.520750988 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis AGE-RAGE signaling pathway in diabetic complications 0.54 0.874505929 0.487516088 kegg kegg NA NA no no no no no no Fatty acid degradation AGE-RAGE signaling pathway in diabetic complications 0 0.630434783 0 kegg kegg NA NA no no no no no no Fatty acid metabolism AGE-RAGE signaling pathway in diabetic complications 0 0.634387352 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway AGE-RAGE signaling pathway in diabetic complications 0.57826087 0.846837945 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis AGE-RAGE signaling pathway in diabetic complications 0 0.696640316 0 kegg kegg NA NA no no no no no no Focal adhesion AGE-RAGE signaling pathway in diabetic complications 0 -0.570158103 0 kegg kegg NA NA no up up no no no Folate biosynthesis AGE-RAGE signaling pathway in diabetic complications -0.517391304 -0.522727273 0 kegg kegg NA NA no no no no no no FoxO signaling pathway AGE-RAGE signaling pathway in diabetic complications 0.491304348 0.670948617 0.437065637 kegg kegg NA NA no no no no no no Fructose and mannose metabolism AGE-RAGE signaling pathway in diabetic complications 0 0.504940711 0 kegg kegg NA NA no no no no no no GABAergic synapse AGE-RAGE signaling pathway in diabetic complications 0.476521739 0.743083004 0 kegg kegg NA NA no up up no no no Galactose metabolism AGE-RAGE signaling pathway in diabetic complications 0 0.648221344 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 -0.749011858 0 kegg kegg NA NA no no no no no no Glutathione metabolism AGE-RAGE signaling pathway in diabetic complications -0.435652174 -0.602766798 -0.430888031 kegg kegg NA NA no no no no no no Glycerolipid metabolism AGE-RAGE signaling pathway in diabetic complications 0 0.476284585 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis AGE-RAGE signaling pathway in diabetic complications 0 -0.584980237 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate AGE-RAGE signaling pathway in diabetic complications 0.46173913 0.7756917 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series AGE-RAGE signaling pathway in diabetic complications 0 -0.436758893 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series AGE-RAGE signaling pathway in diabetic complications -0.439130435 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism AGE-RAGE signaling pathway in diabetic complications 0.414782609 0.833003953 0 kegg kegg NA NA no no no no no no GnRH secretion AGE-RAGE signaling pathway in diabetic complications 0.553043478 0.553359684 0.505534106 kegg kegg NA NA no up up no no no HIF-1 signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 -0.65513834 0 kegg kegg NA NA no no no no no no Hippo signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 -0.665019763 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species AGE-RAGE signaling pathway in diabetic complications 0 0.743083004 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.685770751 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels AGE-RAGE signaling pathway in diabetic complications 0 -0.747035573 0 kegg kegg NA NA no no no no no no Insulin resistance AGE-RAGE signaling pathway in diabetic complications 0 0.673913043 0.457400257 kegg kegg NA NA no no no no no no Insulin signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 -0.725296443 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production AGE-RAGE signaling pathway in diabetic complications 0.460869565 0 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.75 0.422908623 kegg kegg NA NA no no no no no no Linoleic acid metabolism AGE-RAGE signaling pathway in diabetic complications -0.746956522 0 0 kegg kegg NA NA no no no no no no Long-term potentiation AGE-RAGE signaling pathway in diabetic complications 0 -0.538537549 0 kegg kegg NA NA no no up no no no Lysosome AGE-RAGE signaling pathway in diabetic complications 0 0.475296443 0 kegg kegg NA NA no no no no no no MAPK signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0 0.443758044 kegg kegg NA NA no no no no no no Melanogenesis AGE-RAGE signaling pathway in diabetic complications 0 -0.758893281 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 AGE-RAGE signaling pathway in diabetic complications -0.43826087 -0.761857708 0 kegg kegg NA NA no no no no no no Mismatch repair AGE-RAGE signaling pathway in diabetic complications 0 -0.513833992 0 kegg kegg NA NA no no no no no no Mitophagy - animal AGE-RAGE signaling pathway in diabetic complications 0 -0.572134387 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway AGE-RAGE signaling pathway in diabetic complications 0 -0.713438735 0 kegg kegg NA NA no no no no no no mTOR signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 -0.666996047 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis AGE-RAGE signaling pathway in diabetic complications 0 -0.787549407 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity AGE-RAGE signaling pathway in diabetic complications 0 0.443675889 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction AGE-RAGE signaling pathway in diabetic complications 0 0.510869565 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.556324111 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications 0 0.665019763 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway AGE-RAGE signaling pathway in diabetic complications 0.528695652 0.792490119 0.621106821 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism AGE-RAGE signaling pathway in diabetic complications 0.423478261 0.89229249 0 kegg kegg NA NA no no no no no no Nitrogen metabolism AGE-RAGE signaling pathway in diabetic complications 0 0.78458498 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.79743083 0.52046332 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications 0 -0.739130435 -0.435521236 kegg kegg NA NA no no no no no no Notch signaling pathway AGE-RAGE signaling pathway in diabetic complications 0.426956522 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair AGE-RAGE signaling pathway in diabetic complications 0 -0.586956522 0 kegg kegg NA NA no no no no no no Olfactory transduction AGE-RAGE signaling pathway in diabetic complications 0 0.649209486 0 kegg kegg NA NA no no no no no no One carbon pool by folate AGE-RAGE signaling pathway in diabetic complications 0 -0.555335968 0 kegg kegg NA NA no no no no no no Oocyte meiosis AGE-RAGE signaling pathway in diabetic complications 0 -0.62944664 0 kegg kegg NA NA no no no no no no Osteoclast differentiation AGE-RAGE signaling pathway in diabetic complications 0 0.833003953 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation AGE-RAGE signaling pathway in diabetic complications 0 -0.796442688 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis AGE-RAGE signaling pathway in diabetic complications 0.416521739 0.829051383 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" AGE-RAGE signaling pathway in diabetic complications 0 -0.62055336 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions AGE-RAGE signaling pathway in diabetic complications -0.604347826 -0.826086957 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway AGE-RAGE signaling pathway in diabetic complications 0 0.636363636 0 kegg kegg NA NA no no no no no no Peroxisome AGE-RAGE signaling pathway in diabetic complications 0.425217391 0.713438735 0 kegg kegg NA NA no no no no no no Phagosome AGE-RAGE signaling pathway in diabetic complications 0 0.451581028 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism AGE-RAGE signaling pathway in diabetic complications 0 -0.590909091 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway AGE-RAGE signaling pathway in diabetic complications 0.566956522 0.709486166 0 kegg kegg NA NA no up up no no no Phototransduction AGE-RAGE signaling pathway in diabetic complications 0 -0.609683794 0 kegg kegg NA NA no no no no no no Platelet activation AGE-RAGE signaling pathway in diabetic complications 0 -0.479249012 0 kegg kegg NA NA no no no no no no Platinum drug resistance AGE-RAGE signaling pathway in diabetic complications 0.496521739 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.691699605 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway AGE-RAGE signaling pathway in diabetic complications 0.557391304 0.82312253 0.616216216 kegg kegg NA NA no no no no no no Propanoate metabolism AGE-RAGE signaling pathway in diabetic complications 0 -0.635375494 0 kegg kegg NA NA no no no no no no Proteasome AGE-RAGE signaling pathway in diabetic complications 0 -0.657114625 0 kegg kegg NA NA no no no no no no Protein export AGE-RAGE signaling pathway in diabetic complications 0 -0.827075099 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum AGE-RAGE signaling pathway in diabetic complications 0 -0.81916996 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism AGE-RAGE signaling pathway in diabetic complications 0 -0.530632411 0 kegg kegg NA NA no no no no no no Pyruvate metabolism AGE-RAGE signaling pathway in diabetic complications 0 -0.756916996 0 kegg kegg NA NA no no no no no no Ras signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 -0.668972332 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton AGE-RAGE signaling pathway in diabetic complications -0.493913043 -0.422924901 -0.45997426 kegg kegg NA NA no no no no no no Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.431818182 0 kegg kegg NA NA no no no no no no Renin secretion AGE-RAGE signaling pathway in diabetic complications -0.423478261 -0.759881423 0 kegg kegg NA NA no no no no no no Renin-angiotensin system AGE-RAGE signaling pathway in diabetic complications 0 0.637351779 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling AGE-RAGE signaling pathway in diabetic complications -0.408695652 -0.774703557 0 kegg kegg NA NA no no up no no no Ribosome AGE-RAGE signaling pathway in diabetic complications 0 -0.78458498 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes AGE-RAGE signaling pathway in diabetic complications 0 -0.53458498 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.799407115 0.504247104 kegg kegg NA NA no no no no no no RNA degradation AGE-RAGE signaling pathway in diabetic complications 0 -0.793478261 0 kegg kegg NA NA no no no no no no RNA polymerase AGE-RAGE signaling pathway in diabetic complications 0 -0.710474308 0 kegg kegg NA NA no no no no no no RNA transport AGE-RAGE signaling pathway in diabetic complications 0 -0.644268775 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells AGE-RAGE signaling pathway in diabetic complications 0 0 0.449420849 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport AGE-RAGE signaling pathway in diabetic complications 0 0.484189723 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.470355731 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism AGE-RAGE signaling pathway in diabetic complications 0 0.790513834 0 kegg kegg NA NA no no no no no no Steroid biosynthesis AGE-RAGE signaling pathway in diabetic complications 0 -0.469367589 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis AGE-RAGE signaling pathway in diabetic complications -0.483478261 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle AGE-RAGE signaling pathway in diabetic complications 0 0.636363636 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies AGE-RAGE signaling pathway in diabetic complications 0 -0.52173913 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.416007905 0 kegg kegg NA NA no no no no no no Taste transduction AGE-RAGE signaling pathway in diabetic complications 0 -0.490118577 0 kegg kegg NA NA no no up no no no TGF-beta signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 -0.732213439 0 kegg kegg NA NA no no no no no no Thermogenesis AGE-RAGE signaling pathway in diabetic complications 0 -0.847826087 -0.483397683 kegg kegg NA NA no no no no no no Thiamine metabolism AGE-RAGE signaling pathway in diabetic complications 0 -0.59486166 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 -0.53458498 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis AGE-RAGE signaling pathway in diabetic complications 0 -0.451581028 0 kegg kegg NA NA no no no no no no Tight junction AGE-RAGE signaling pathway in diabetic complications -0.430434783 -0.494071146 -0.43989704 kegg kegg NA NA no no no no no no TNF signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.684782609 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 0.828063241 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism AGE-RAGE signaling pathway in diabetic complications 0 -0.485177866 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus AGE-RAGE signaling pathway in diabetic complications 0 0.739130435 0.592792793 kegg kegg NA NA no no no no no no Tyrosine metabolism AGE-RAGE signaling pathway in diabetic complications 0 -0.571146245 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis AGE-RAGE signaling pathway in diabetic complications 0 -0.503952569 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis AGE-RAGE signaling pathway in diabetic complications 0 -0.663043478 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" AGE-RAGE signaling pathway in diabetic complications 0 -0.669960474 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis AGE-RAGE signaling pathway in diabetic complications 0 -0.65513834 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction AGE-RAGE signaling pathway in diabetic complications 0 -0.711462451 0 kegg kegg NA NA no no no no no no VEGF signaling pathway AGE-RAGE signaling pathway in diabetic complications 0.53826087 0.66798419 0.405148005 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor AGE-RAGE signaling pathway in diabetic complications 0 0 -0.517117117 kegg kegg NA NA no no no no no no Wnt signaling pathway AGE-RAGE signaling pathway in diabetic complications 0 -0.780632411 0 kegg kegg NA NA no no no no no no Arginine biosynthesis "Alanine, aspartate and glutamate metabolism" 0.980869565 0.97826087 0.968854569 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism "Alanine, aspartate and glutamate metabolism" 0 -0.441699605 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) "Alanine, aspartate and glutamate metabolism" 0 -0.649209486 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis "Alanine, aspartate and glutamate metabolism" 0.897391304 0.95256917 0.792792793 kegg kegg NA NA no no no no no no Fatty acid degradation "Alanine, aspartate and glutamate metabolism" 0.706086957 0.778656126 0.495238095 kegg kegg NA NA no no no no no no Galactose metabolism "Alanine, aspartate and glutamate metabolism" 0 0.581027668 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis "Alanine, aspartate and glutamate metabolism" 0 -0.511857708 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation "Alanine, aspartate and glutamate metabolism" -0.543478261 -0.768774704 -0.511196911 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions "Alanine, aspartate and glutamate metabolism" -0.436521739 -0.809288538 -0.577348777 kegg kegg NA NA no no no no no no Pentose phosphate pathway "Alanine, aspartate and glutamate metabolism" 0.413043478 0.588932806 0.693951094 kegg kegg NA NA no no no no no no Pyrimidine metabolism "Alanine, aspartate and glutamate metabolism" 0 -0.634387352 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis "Alanine, aspartate and glutamate metabolism" 0 -0.444664032 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Alcoholism -0.54173913 -0.522727273 -0.49009009 kegg kegg NA NA no no no no no no ABC transporters Alcoholism -0.489565217 0 -0.508622909 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes Alcoholism 0.510434783 0 0.414929215 kegg kegg NA NA no no up no no no Aldosterone synthesis and secretion Alcoholism 0 0 0.479279279 kegg kegg NA NA no up up no no no Alistipes Alcoholism 0 -0.447252486 0 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism Alcoholism -0.625217391 0 -0.469240669 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Alcoholism 0 0 -0.56036036 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Alcoholism -0.622608696 -0.653162055 -0.45019305 kegg kegg NA NA no no no no no no Amphetamine addiction Alcoholism 0 0 0.53976834 kegg kegg NA NA no no no no no no Anaerostipes Alcoholism 0 -0.415002709 0 butyrate-producing Genus kegg 0.568 NA no no no no no no Antifolate resistance Alcoholism -0.582608696 0 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Alcoholism 0.410434783 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Alcoholism 0 -0.419960474 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Alcoholism 0 0.432806324 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Alcoholism -0.529565217 0 -0.694465894 kegg kegg NA NA no no no no no no Autophagy - other Alcoholism 0 -0.450592885 0 kegg kegg NA NA no no no no no no Axon guidance Alcoholism 0.665217391 0 0 kegg kegg NA NA no up up no no no Basal transcription factors Alcoholism 0 -0.442687747 -0.41029601 kegg kegg NA NA no no no no no no beta-Alanine metabolism Alcoholism -0.563478261 0 0 kegg kegg NA NA no no no no no no Bile secretion Alcoholism 0 0.416007905 0.638610039 kegg kegg NA NA no no no no no no Butanoate metabolism Alcoholism -0.450434783 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Alcoholism 0.485217391 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Alcoholism 0.433913043 0 0.509395109 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Alcoholism 0 0 -0.552895753 kegg kegg NA NA no no no no no no Cell cycle Alcoholism 0 -0.492094862 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Alcoholism 0 0.455533597 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Alcoholism 0 0.499011858 0.407722008 kegg kegg NA NA no no no no no no Circadian entrainment Alcoholism 0 0 0.679279279 kegg kegg NA NA no up up no no no Circadian rhythm Alcoholism 0 -0.443675889 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Alcoholism -0.486956522 0 -0.518918919 kegg kegg NA NA no no no no no no Cocaine addiction Alcoholism 0 0 0.685971686 kegg kegg NA NA no no no no no no Collecting duct acid secretion Alcoholism 0 0.438735178 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Alcoholism 0 0.527667984 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Alcoholism 0 0 0.575032175 kegg kegg NA NA no no up no no no DNA replication Alcoholism 0 0 -0.422908623 kegg kegg NA NA no no no no no no Dopaminergic synapse Alcoholism 0.492173913 0 0.505276705 kegg kegg NA NA no up no no no no Endocrine and other factor-regulated calcium reabsorption Alcoholism 0 0 0.50990991 kegg kegg NA NA no no no no no no Ether lipid metabolism Alcoholism 0 0 -0.501415701 kegg kegg NA NA no no no no no no Fanconi anemia pathway Alcoholism 0 -0.545454545 -0.496525097 kegg kegg NA NA no no no no no no Fatty acid degradation Alcoholism 0 0 -0.482882883 kegg kegg NA NA no no no no no no Folate biosynthesis Alcoholism 0 -0.529644269 -0.435778636 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Alcoholism -0.460869565 0 -0.491891892 kegg kegg NA NA no no no no no no GABAergic synapse Alcoholism 0 0.516798419 0 kegg kegg NA NA no up up no no no Galactose metabolism Alcoholism -0.556521739 0 -0.637323037 kegg kegg NA NA no no no no no no Gap junction Alcoholism 0 0.483201581 0.628828829 kegg kegg NA NA no no no no no no Glutamatergic synapse Alcoholism 0.419130435 0.556324111 0.662805663 kegg kegg NA NA no up up no no no Glycerolipid metabolism Alcoholism -0.422608696 0 -0.594594595 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Alcoholism 0 0 -0.58970399 kegg kegg NA NA no no up no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Alcoholism 0 -0.435770751 -0.55006435 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Alcoholism 0 0 -0.531274131 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Alcoholism 0 -0.466403162 -0.531531532 kegg kegg NA NA no no no no no no GnRH secretion Alcoholism 0 0 -0.483655084 kegg kegg NA NA no up up no no no GnRH signaling pathway Alcoholism 0.44173913 0 0.648906049 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Alcoholism 0 -0.618577075 -0.474646075 kegg kegg NA NA no no no no no no Histidine metabolism Alcoholism -0.632173913 0 -0.610553411 kegg kegg NA NA no no no no no no Homologous recombination Alcoholism 0 -0.523715415 -0.406177606 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Alcoholism -0.659130435 -0.469367589 -0.703989704 kegg kegg NA NA no no no no no no Insulin secretion Alcoholism 0 0 0.570656371 yes kegg kegg NA NA no up up no no no JAK-STAT signaling pathway Alcoholism 0 0 -0.473873874 kegg kegg NA NA no no no no no no Long-term depression Alcoholism 0 0.43083004 0.681081081 kegg kegg NA NA no no no no no no Long-term potentiation Alcoholism 0.410434783 0 0 kegg kegg NA NA no no up no no no Lysine degradation Alcoholism 0 -0.691699605 -0.451222651 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Alcoholism 0 -0.708498024 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Alcoholism 0 -0.473320158 -0.418018018 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Alcoholism 0 0 -0.540540541 kegg kegg NA NA no up no no no no Melanogenesis Alcoholism 0 0 0.482882883 kegg kegg NA NA no no no no no no Methanobrevibacter Alcoholism 0 -0.422326513 0 Genus kegg 0.629 NA no no no no no no Morphine addiction Alcoholism 0.467826087 0 0.751866152 kegg kegg NA NA no up up no no no mRNA surveillance pathway Alcoholism 0 -0.448616601 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Alcoholism 0 -0.470355731 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Alcoholism 0 -0.477272727 -0.420849421 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Alcoholism 0 0.559288538 0 kegg kegg NA NA no no no no no no Nicotine addiction Alcoholism 0 -0.455533597 0 kegg kegg NA NA no up up no no no Nitrogen metabolism Alcoholism 0 0.442687747 0 kegg kegg NA NA no no no no no no Notch signaling pathway Alcoholism 0 0 -0.508365508 kegg kegg NA NA no no no no no no Olfactory transduction Alcoholism 0 0.459486166 0 kegg kegg NA NA no no no no no no One carbon pool by folate Alcoholism -0.484347826 0 -0.5997426 kegg kegg NA NA no no no no no no Other glycan degradation Alcoholism 0 -0.42687747 -0.554954955 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Alcoholism 0 -0.522727273 -0.527413127 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Alcoholism 0 0 0.624967825 kegg kegg NA NA no up up no no no Oxytocin signaling pathway Alcoholism 0 0.53458498 0 kegg kegg NA NA no no no no no no Pancreatic secretion Alcoholism 0.452173913 0 0.645817246 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Alcoholism 0 0 0.471814672 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Alcoholism 0 -0.434782609 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Alcoholism 0 0.43083004 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Alcoholism -0.479130435 0 -0.454568855 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Alcoholism 0 0 -0.441441441 kegg kegg NA NA no no no no no no Platinum drug resistance Alcoholism 0 -0.508893281 -0.438867439 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Alcoholism 0 -0.518774704 -0.473616474 kegg kegg NA NA no no no no no no Protein digestion and absorption Alcoholism -0.486956522 0 0 yes kegg kegg NA NA no up up no no no Protein processing in endoplasmic reticulum Alcoholism 0 -0.454545455 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Alcoholism -0.43826087 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Alcoholism 0 0.421936759 0 kegg kegg NA NA no no no no no no Ras signaling pathway Alcoholism 0.484347826 0 0 yes kegg kegg NA NA no up up no no no Regulation of lipolysis in adipocytes Alcoholism 0 0 0.593307593 kegg kegg NA NA no no no no no no Relaxin signaling pathway Alcoholism 0 0 0.552380952 kegg kegg NA NA no no no no no no Renin secretion Alcoholism 0 0 0.572200772 kegg kegg NA NA no no no no no no Retinol metabolism Alcoholism 0 0 -0.491119691 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Alcoholism 0.407826087 0 0 kegg kegg NA NA no no up no no no Ribosome biogenesis in eukaryotes Alcoholism 0 -0.535573123 -0.47001287 kegg kegg NA NA no no no no no no RNA degradation Alcoholism 0 -0.48715415 0 kegg kegg NA NA no no no no no no RNA polymerase Alcoholism 0 -0.516798419 -0.450965251 kegg kegg NA NA no no no no no no Ruminococcus Alcoholism 0 -0.470355731 0 acetate-producing Genus kegg 0.335 NA no no no no no no Salivary secretion Alcoholism 0.437391304 0.557312253 0.661518662 kegg kegg NA NA no no no no no no Selenocompound metabolism Alcoholism 0 -0.472332016 -0.67001287 kegg kegg NA NA no no no no no no Serotonergic synapse Alcoholism 0 0.62055336 0.671814672 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Alcoholism 0 -0.498023715 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Alcoholism 0 0 -0.41003861 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Alcoholism 0 -0.603754941 -0.458429858 kegg kegg NA NA no no no no no no Spliceosome Alcoholism 0 -0.588932806 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Alcoholism 0 0 -0.43011583 kegg kegg NA NA no no no no no no Steroid biosynthesis Alcoholism 0 0 -0.404890605 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Alcoholism 0 0 -0.638867439 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Alcoholism 0 0.418972332 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Alcoholism 0 0 -0.427799228 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Alcoholism 0 -0.48715415 0 kegg kegg NA NA no no no no no no Taste transduction Alcoholism 0 0 -0.64993565 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Alcoholism 0 0 -0.434749035 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Alcoholism 0 0 -0.501158301 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Alcoholism 0 -0.483201581 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Alcoholism 0 -0.539525692 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Alcoholism 0 0 0.523294723 kegg kegg NA NA no no no no no no Tryptophan metabolism Alcoholism -0.528695652 0 -0.454311454 kegg kegg NA NA no up no no no no Type II diabetes mellitus Alcoholism 0 0 -0.531016731 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Alcoholism -0.43826087 0 -0.484942085 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Alcoholism -0.54173913 0 -0.455855856 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Alcoholism 0 -0.545454545 -0.40978121 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Alcoholism 0.532173913 0 0.618790219 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Alcoholism 0 0 0.614414414 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Alcoholism 0.470434783 0.660079051 0.428056628 kegg kegg NA NA no no no no no no Wnt signaling pathway Alcoholism 0 -0.433794466 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Aldosterone synthesis and secretion -0.425217391 0 0 kegg kegg NA NA no no no no up up ABC transporters Aldosterone synthesis and secretion -0.640869565 0 0 kegg kegg NA NA no up up no up up Adrenergic signaling in cardiomyocytes Aldosterone synthesis and secretion 0.831304348 0.854743083 0.912998713 kegg kegg NA NA no no up no up up "Alanine, aspartate and glutamate metabolism" Aldosterone synthesis and secretion -0.494782609 -0.646245059 -0.531274131 kegg kegg NA NA no no no no up up alpha-Linolenic acid metabolism Aldosterone synthesis and secretion -0.805217391 -0.586956522 -0.603861004 kegg kegg NA NA no no no no up up Amino sugar and nucleotide sugar metabolism Aldosterone synthesis and secretion -0.606956522 0 -0.517117117 kegg kegg NA NA no no no no up up Aminoacyl-tRNA biosynthesis Aldosterone synthesis and secretion -0.459130435 0 0 kegg kegg NA NA no no no no up up AMPK signaling pathway Aldosterone synthesis and secretion 0 0.608695652 0 kegg kegg NA NA no no no no up up Antigen processing and presentation Aldosterone synthesis and secretion -0.415652174 0 0 kegg kegg NA NA no no no no up up Apelin signaling pathway Aldosterone synthesis and secretion 0 0.605731225 0 kegg kegg NA NA no no no no up up Apoptosis Aldosterone synthesis and secretion -0.599130435 -0.666007905 -0.421621622 kegg kegg NA NA no no no no up up Arginine and proline metabolism Aldosterone synthesis and secretion -0.676521739 -0.685770751 -0.42033462 kegg kegg NA NA no up no no up up Arginine biosynthesis Aldosterone synthesis and secretion -0.529565217 -0.637351779 -0.523294723 kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism Aldosterone synthesis and secretion 0 0 -0.431917632 kegg kegg NA NA no no no no up up Autophagy - animal Aldosterone synthesis and secretion 0 -0.471343874 0 kegg kegg NA NA no no no no up up B cell receptor signaling pathway Aldosterone synthesis and secretion 0 -0.593873518 0 kegg kegg NA NA no no no no up up Basal transcription factors Aldosterone synthesis and secretion 0 0.442687747 0 kegg kegg NA NA no no no no up up beta-Alanine metabolism Aldosterone synthesis and secretion -0.584347826 0 -0.517631918 kegg kegg NA NA no no no no up up Biosynthesis of amino acids Aldosterone synthesis and secretion -0.665217391 -0.836956522 -0.648906049 kegg kegg NA NA no no no no up up Biosynthesis of cofactors Aldosterone synthesis and secretion 0 0.549407115 0 kegg kegg NA NA no no no no up up Butanoate metabolism Aldosterone synthesis and secretion -0.442608696 0 0 kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway Aldosterone synthesis and secretion 0 -0.60770751 0 kegg kegg NA NA no no no no up up Calcium signaling pathway Aldosterone synthesis and secretion 0.845217391 0.78458498 0.871042471 kegg kegg NA NA no up up no up up cAMP signaling pathway Aldosterone synthesis and secretion 0.587826087 0 0.583526384 yes kegg kegg NA NA no up up no up up Carbon metabolism Aldosterone synthesis and secretion -0.583478261 -0.565217391 -0.718661519 kegg kegg NA NA no no no no up up Cardiac muscle contraction Aldosterone synthesis and secretion 0.59826087 0.756916996 0.42007722 kegg kegg NA NA no no up no up up Cell adhesion molecules Aldosterone synthesis and secretion 0 -0.739130435 0 kegg kegg NA NA no no no no up up Cell cycle Aldosterone synthesis and secretion 0 0.590909091 0.437580438 kegg kegg NA NA no no no no up up Cellular senescence Aldosterone synthesis and secretion 0 -0.606719368 0 kegg kegg NA NA no no no no up up cGMP-PKG signaling pathway Aldosterone synthesis and secretion 0 -0.747035573 0 kegg kegg NA NA no no no no up up Chemokine signaling pathway Aldosterone synthesis and secretion 0 -0.500988142 0 kegg kegg NA NA no no no no up up Circadian entrainment Aldosterone synthesis and secretion 0.622608696 0.580039526 0.675160875 kegg kegg NA NA no up up no up up Circadian rhythm Aldosterone synthesis and secretion 0.500869565 0.619565217 0.431917632 kegg kegg NA NA no no no no up up Complement and coagulation cascades Aldosterone synthesis and secretion -0.512173913 -0.731225296 0 kegg kegg NA NA no no no no up up Coprococcus Aldosterone synthesis and secretion 0 0 -0.490250339 butyrate-producing Genus kegg 0.612 NA no no no no up up Cytokine-cytokine receptor interaction Aldosterone synthesis and secretion 0 -0.415019763 0 kegg kegg NA NA no no no no up up DNA replication Aldosterone synthesis and secretion 0 0.456521739 0 kegg kegg NA NA no no no no up up Dopaminergic synapse Aldosterone synthesis and secretion 0.762608696 0.759881423 0.911454311 kegg kegg NA NA no up no no up up Drug metabolism - other enzymes Aldosterone synthesis and secretion -0.537391304 0 -0.508365508 kegg kegg NA NA no no no no up up ECM-receptor interaction Aldosterone synthesis and secretion 0 0 0.434234234 kegg kegg NA NA no up up no up up EGFR tyrosine kinase inhibitor resistance Aldosterone synthesis and secretion 0 0.561264822 0 kegg kegg NA NA no no no no up up Endocrine resistance Aldosterone synthesis and secretion 0.794782609 0.654150198 0.674388674 kegg kegg NA NA no no no no up up Endocytosis Aldosterone synthesis and secretion 0 -0.741106719 0 kegg kegg NA NA no no no no up up Estrogen signaling pathway Aldosterone synthesis and secretion 0 0.424901186 0 kegg kegg NA NA no no no no up up Ether lipid metabolism Aldosterone synthesis and secretion 0.491304348 0.551383399 0 kegg kegg NA NA no no no no up up Fatty acid biosynthesis Aldosterone synthesis and secretion -0.48173913 -0.673913043 -0.511969112 kegg kegg NA NA no no no no up up Fatty acid degradation Aldosterone synthesis and secretion -0.68173913 -0.678853755 -0.721750322 kegg kegg NA NA no no no no up up Fatty acid elongation Aldosterone synthesis and secretion -0.427826087 0 0 kegg kegg NA NA no no no no up up Fatty acid metabolism Aldosterone synthesis and secretion -0.713913043 -0.725296443 -0.62007722 kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway Aldosterone synthesis and secretion 0 -0.658102767 0 kegg kegg NA NA no no no no up up Fc gamma R-mediated phagocytosis Aldosterone synthesis and secretion -0.615652174 -0.815217391 -0.542857143 kegg kegg NA NA no no no no up up Fructose and mannose metabolism Aldosterone synthesis and secretion -0.670434783 0 -0.685199485 kegg kegg NA NA no no no no up up GABAergic synapse Aldosterone synthesis and secretion 0 -0.429841897 0 kegg kegg NA NA no up up no up up Galactose metabolism Aldosterone synthesis and secretion -0.715652174 -0.606719368 -0.560617761 kegg kegg NA NA no no no no up up Gap junction Aldosterone synthesis and secretion 0.664347826 0.438735178 0.425740026 kegg kegg NA NA no no no no up up Glucagon signaling pathway Aldosterone synthesis and secretion 0.830434783 0.933794466 0.842471042 kegg kegg NA NA no no no no up up Glutamatergic synapse Aldosterone synthesis and secretion 0.613913043 0 0 kegg kegg NA NA no up up no up up Glutathione metabolism Aldosterone synthesis and secretion 0 0.621541502 0 kegg kegg NA NA no no no no up up Glycerolipid metabolism Aldosterone synthesis and secretion -0.451304348 0 0 kegg kegg NA NA no no up no up up "Glycine, serine and threonine metabolism" Aldosterone synthesis and secretion 0 0.548418972 0 kegg kegg NA NA no up no no up up Glycolysis / Gluconeogenesis Aldosterone synthesis and secretion -0.502608696 0 -0.472072072 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Aldosterone synthesis and secretion 0 -0.427865613 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate Aldosterone synthesis and secretion 0.615652174 0 0 kegg kegg NA NA no no no no up up Glycosaminoglycan degradation Aldosterone synthesis and secretion 0 -0.679841897 0 kegg kegg NA NA no no up no up up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Aldosterone synthesis and secretion 0 0.422924901 0 kegg kegg NA NA no no no no up up Glyoxylate and dicarboxylate metabolism Aldosterone synthesis and secretion -0.657391304 -0.669960474 -0.615186615 kegg kegg NA NA no no no no up up GnRH signaling pathway Aldosterone synthesis and secretion 0.905217391 0.865612648 0.897812098 kegg kegg NA NA no no no no up up Hedgehog signaling pathway Aldosterone synthesis and secretion 0.563478261 0 0 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Aldosterone synthesis and secretion -0.413043478 -0.587944664 0 kegg kegg NA NA no no no no up up Histidine metabolism Aldosterone synthesis and secretion -0.58 0 -0.697812098 kegg kegg NA NA no no no no up up IL-17 signaling pathway Aldosterone synthesis and secretion 0 -0.70256917 -0.505534106 kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels Aldosterone synthesis and secretion 0.889565217 0.856719368 0.915057915 kegg kegg NA NA no no no no up up Insulin secretion Aldosterone synthesis and secretion 0.823478261 0.885375494 0.879021879 yes kegg kegg NA NA no up up no up up Insulin signaling pathway Aldosterone synthesis and secretion 0 0.546442688 0 kegg kegg NA NA no no no no up up Long-term depression Aldosterone synthesis and secretion 0.844347826 0.467391304 0.692664093 kegg kegg NA NA no no no no up up Long-term potentiation Aldosterone synthesis and secretion 0.469565217 0 0 kegg kegg NA NA no no up no up up Longevity regulating pathway Aldosterone synthesis and secretion 0.467826087 0 0 kegg kegg NA NA no no no no up up Longevity regulating pathway - multiple species Aldosterone synthesis and secretion 0 -0.504940711 0 kegg kegg NA NA no no no no up up Lysosome Aldosterone synthesis and secretion 0 -0.719367589 -0.619305019 kegg kegg NA NA no no no no up up Melanogenesis Aldosterone synthesis and secretion 0.847826087 0.906126482 0.933075933 kegg kegg NA NA no no no no up up Mitophagy - animal Aldosterone synthesis and secretion 0.616521739 0.732213439 0 kegg kegg NA NA no no no no up up mRNA surveillance pathway Aldosterone synthesis and secretion 0.553913043 0.736166008 0.513513514 kegg kegg NA NA no no no no up up mTOR signaling pathway Aldosterone synthesis and secretion 0 0.532608696 0 kegg kegg NA NA no no no no up up N-Glycan biosynthesis Aldosterone synthesis and secretion 0 0.563241107 0 kegg kegg NA NA no no no no up up Natural killer cell mediated cytotoxicity Aldosterone synthesis and secretion 0 -0.652173913 0 kegg kegg NA NA no no no no up up Necroptosis Aldosterone synthesis and secretion 0.542608696 0 0 kegg kegg NA NA no no no no up up Neuroactive ligand-receptor interaction Aldosterone synthesis and secretion -0.486956522 -0.793478261 -0.552123552 kegg kegg NA NA up up up no up up Neutrophil extracellular trap formation Aldosterone synthesis and secretion -0.582608696 -0.736166008 -0.482625483 kegg kegg NA NA no no no no up up NF-kappa B signaling pathway Aldosterone synthesis and secretion -0.491304348 -0.507905138 0 kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Aldosterone synthesis and secretion -0.605217391 -0.651185771 -0.560875161 kegg kegg NA NA no no no no up up Nitrogen metabolism Aldosterone synthesis and secretion -0.407826087 -0.504940711 0 kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Aldosterone synthesis and secretion -0.692173913 -0.718379447 0 kegg kegg NA NA no no no no up up Non-homologous end-joining Aldosterone synthesis and secretion -0.412173913 0 0 kegg kegg NA NA no no no no up up Nucleotide excision repair Aldosterone synthesis and secretion 0 0.43083004 0 kegg kegg NA NA no no no no up up Odoribacter Aldosterone synthesis and secretion -0.410611339 0 0 butyrate-producing Genus kegg 0.798 NA no no no no up up Olfactory transduction Aldosterone synthesis and secretion 0 -0.692687747 -0.618790219 kegg kegg NA NA no no no no up up One carbon pool by folate Aldosterone synthesis and secretion 0 0.463438735 0 kegg kegg NA NA no no no no up up Oocyte meiosis Aldosterone synthesis and secretion 0 0 0.432689833 kegg kegg NA NA no no no no up up Osteoclast differentiation Aldosterone synthesis and secretion -0.7 -0.790513834 -0.439124839 kegg kegg NA NA no no no no up up Other glycan degradation Aldosterone synthesis and secretion -0.626956522 0 0 kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis Aldosterone synthesis and secretion 0 0.43972332 0 kegg kegg NA NA no no no no up up Ovarian steroidogenesis Aldosterone synthesis and secretion 0.663478261 0.640316206 0.554697555 kegg kegg NA NA no up up no up up Oxidative phosphorylation Aldosterone synthesis and secretion 0.555652174 0.745059289 0 kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis Aldosterone synthesis and secretion -0.490434783 -0.734189723 -0.723294723 kegg kegg NA NA no no dn no up up Pentose phosphate pathway Aldosterone synthesis and secretion -0.522608696 -0.795454545 -0.675933076 kegg kegg NA NA no no no no up up Peroxisome Aldosterone synthesis and secretion -0.680869565 -0.742094862 -0.555469755 kegg kegg NA NA no no no no up up Phagosome Aldosterone synthesis and secretion 0 -0.742094862 0 kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system Aldosterone synthesis and secretion 0.589565217 0 0 kegg kegg NA NA no no no no up up Porphyrin and chlorophyll metabolism Aldosterone synthesis and secretion 0 0.462450593 0 kegg kegg NA NA no no no no up up PPAR signaling pathway Aldosterone synthesis and secretion -0.442608696 -0.735177866 0 kegg kegg NA NA no no no no up up Prevotella Aldosterone synthesis and secretion -0.415215659 0 0 Genus kegg 0.367 NA no no no no up up Prevotella Aldosterone synthesis and secretion 0 0 0.47767746 acetate-producing Genus kegg 0.287 NA no no no no up up Prolactin signaling pathway Aldosterone synthesis and secretion 0 -0.554347826 0 kegg kegg NA NA no no no no up up Proteasome Aldosterone synthesis and secretion 0 0 -0.458944659 kegg kegg NA NA no no no no up up Protein export Aldosterone synthesis and secretion 0.442608696 0.496047431 0 kegg kegg NA NA no no no no up up Protein processing in endoplasmic reticulum Aldosterone synthesis and secretion 0.463478261 0.595849802 0 kegg kegg NA NA no no no no up up Purine metabolism Aldosterone synthesis and secretion 0 0.548418972 0 kegg kegg NA NA no no no no up up Pyrimidine metabolism Aldosterone synthesis and secretion -0.593043478 0 0 kegg kegg NA NA no no no no up up Pyruvate metabolism Aldosterone synthesis and secretion 0 0.440711462 0 kegg kegg NA NA no no no no up up Ras signaling pathway Aldosterone synthesis and secretion 0 0.469367589 0 yes kegg kegg NA NA no up up no up up Regulation of lipolysis in adipocytes Aldosterone synthesis and secretion 0.769565217 0.670948617 0.702960103 kegg kegg NA NA no no no no up up Renin secretion Aldosterone synthesis and secretion 0.686086957 0.772727273 0.696267696 kegg kegg NA NA no no no no up up Renin-angiotensin system Aldosterone synthesis and secretion 0 -0.772727273 -0.551093951 kegg kegg NA NA no no no no up up Retinol metabolism Aldosterone synthesis and secretion -0.477391304 0 0 kegg kegg NA NA no no no no up up Retrograde endocannabinoid signaling Aldosterone synthesis and secretion 0 0.685770751 0 kegg kegg NA NA no no up no up up Ribosome Aldosterone synthesis and secretion 0.553913043 0.691699605 0 kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes Aldosterone synthesis and secretion 0 0.517786561 0 kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway Aldosterone synthesis and secretion 0 -0.524703557 0 kegg kegg NA NA no no no no up up RNA degradation Aldosterone synthesis and secretion 0.527826087 0.690711462 0 kegg kegg NA NA no no no no up up RNA polymerase Aldosterone synthesis and secretion 0 0.674901186 0 kegg kegg NA NA no no no no up up Sarcina Aldosterone synthesis and secretion 0 -0.422326513 0 Genus kegg 0.0703 NA no no no no up up Signaling pathways regulating pluripotency of stem cells Aldosterone synthesis and secretion 0.445217391 0 0 kegg kegg NA NA no no no no up up SNARE interactions in vesicular transport Aldosterone synthesis and secretion -0.526956522 -0.455533597 0 kegg kegg NA NA no no no no up up Sphingolipid metabolism Aldosterone synthesis and secretion 0 0 -0.464607465 kegg kegg NA NA no no no no up up Sphingolipid signaling pathway Aldosterone synthesis and secretion 0 -0.517786561 0 kegg kegg NA NA no no no no up up Starch and sucrose metabolism Aldosterone synthesis and secretion -0.733913043 -0.681818182 -0.720978121 kegg kegg NA NA no no no no up up Steroid biosynthesis Aldosterone synthesis and secretion 0.448695652 0 0 kegg kegg NA NA no no no no up up Synaptic vesicle cycle Aldosterone synthesis and secretion 0 -0.76284585 -0.696267696 kegg kegg NA NA no up up no up up Taste transduction Aldosterone synthesis and secretion 0 0.456521739 0 kegg kegg NA NA no no up no up up TGF-beta signaling pathway Aldosterone synthesis and secretion 0.486956522 0.491106719 0 kegg kegg NA NA no no no no up up Th1 and Th2 cell differentiation Aldosterone synthesis and secretion 0 -0.46541502 0 kegg kegg NA NA no no no no up up Th17 cell differentiation Aldosterone synthesis and secretion 0 -0.480237154 0 kegg kegg NA NA no no no no up up Thermogenesis Aldosterone synthesis and secretion 0.633913043 0.772727273 0 kegg kegg NA NA no no no no up up Thyroid hormone signaling pathway Aldosterone synthesis and secretion 0 0.424901186 0 kegg kegg NA NA no no no no up up Thyroid hormone synthesis Aldosterone synthesis and secretion 0.733913043 0.802371542 0.531788932 kegg kegg NA NA no no no no up up TNF signaling pathway Aldosterone synthesis and secretion 0 -0.425889328 0 kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway Aldosterone synthesis and secretion 0 -0.644268775 0 yes kegg kegg NA NA no no no no up up Tryptophan metabolism Aldosterone synthesis and secretion -0.5 0 -0.413899614 kegg kegg NA NA no up no no up up Ubiquitin mediated proteolysis Aldosterone synthesis and secretion 0.663478261 0.789525692 0 kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Aldosterone synthesis and secretion 0.787826087 0.683794466 0.65971686 kegg kegg NA NA no no no no up up Wnt signaling pathway Aldosterone synthesis and secretion 0.619130435 0.695652174 0 kegg kegg NA NA no no no no up up 2-Oxocarboxylic acid metabolism Aldosterone-regulated sodium reabsorption -0.576521739 0 0 kegg kegg NA NA no no no no no no ABC transporters Aldosterone-regulated sodium reabsorption -0.439130435 0 0 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes Aldosterone-regulated sodium reabsorption 0.535652174 0 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Aldosterone-regulated sodium reabsorption 0.488695652 0.5256917 0.689317889 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Aldosterone-regulated sodium reabsorption -0.613913043 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Aldosterone-regulated sodium reabsorption -0.46173913 -0.511857708 0 kegg kegg NA NA no no no no no no Antifolate resistance Aldosterone-regulated sodium reabsorption -0.50173913 0 0 kegg kegg NA NA no no no no no no Apoptosis Aldosterone-regulated sodium reabsorption 0 0.416996047 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Aldosterone-regulated sodium reabsorption -0.665217391 0 -0.545431145 kegg kegg NA NA no no no no no no Arginine and proline metabolism Aldosterone-regulated sodium reabsorption 0 0.448616601 0 kegg kegg NA NA no up no no no no Ascorbate and aldarate metabolism Aldosterone-regulated sodium reabsorption -0.496521739 0 0 kegg kegg NA NA no no no no no no Autophagy - animal Aldosterone-regulated sodium reabsorption 0.599130435 0.514822134 0.784555985 kegg kegg NA NA no no no no no no Autophagy - other Aldosterone-regulated sodium reabsorption 0.448695652 0 0.482882883 kegg kegg NA NA no no no no no no Axon guidance Aldosterone-regulated sodium reabsorption 0.626086957 0.633399209 0.567052767 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Aldosterone-regulated sodium reabsorption 0 0.546442688 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Aldosterone-regulated sodium reabsorption -0.657391304 -0.463438735 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Aldosterone-regulated sodium reabsorption -0.673043478 -0.414031621 -0.425997426 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Aldosterone-regulated sodium reabsorption -0.512173913 -0.471343874 0 kegg kegg NA NA no no no no no no Butanoate metabolism Aldosterone-regulated sodium reabsorption -0.682608696 -0.502964427 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Aldosterone-regulated sodium reabsorption 0.671304348 0.572134387 0.431917632 kegg kegg NA NA no no no no no no Calcium signaling pathway Aldosterone-regulated sodium reabsorption 0.527826087 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Aldosterone-regulated sodium reabsorption 0.644347826 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Aldosterone-regulated sodium reabsorption -0.480869565 0 0 kegg kegg NA NA no no no no no no Cellular senescence Aldosterone-regulated sodium reabsorption 0 0.458498024 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Aldosterone-regulated sodium reabsorption 0.526086957 0 0.471814672 kegg kegg NA NA no no no no no no Chemokine signaling pathway Aldosterone-regulated sodium reabsorption 0.452173913 0.520750988 0 kegg kegg NA NA no no no no no no Cholinergic synapse Aldosterone-regulated sodium reabsorption 0.712173913 0 0.477477477 kegg kegg NA NA no no no no no no Circadian entrainment Aldosterone-regulated sodium reabsorption 0 0 -0.416988417 kegg kegg NA NA no up up no no no Circadian rhythm Aldosterone-regulated sodium reabsorption 0.599130435 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Aldosterone-regulated sodium reabsorption -0.511304348 -0.551383399 0 kegg kegg NA NA no no no no no no DNA replication Aldosterone-regulated sodium reabsorption 0 -0.503952569 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Aldosterone-regulated sodium reabsorption 0 -0.529644269 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Aldosterone-regulated sodium reabsorption -0.594782609 -0.416007905 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Aldosterone-regulated sodium reabsorption 0.74 0.704545455 0.741827542 kegg kegg NA NA no no no no no no Estrogen signaling pathway Aldosterone-regulated sodium reabsorption 0 -0.619565217 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Aldosterone-regulated sodium reabsorption 0 0 0.415701416 kegg kegg NA NA no no no no no no Fatty acid elongation Aldosterone-regulated sodium reabsorption -0.535652174 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Aldosterone-regulated sodium reabsorption 0.597391304 0.548418972 0.56036036 kegg kegg NA NA no no no no no no Ferroptosis Aldosterone-regulated sodium reabsorption 0 0 -0.422136422 kegg kegg NA NA no no no no no no FoxO signaling pathway Aldosterone-regulated sodium reabsorption 0.44173913 0 0.445302445 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Aldosterone-regulated sodium reabsorption -0.583478261 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Aldosterone-regulated sodium reabsorption -0.58173913 0 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Aldosterone-regulated sodium reabsorption 0 -0.425889328 0 kegg kegg NA NA no no no no no no Glutathione metabolism Aldosterone-regulated sodium reabsorption -0.496521739 0 -0.603088803 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Aldosterone-regulated sodium reabsorption -0.451304348 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Aldosterone-regulated sodium reabsorption -0.530434783 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Aldosterone-regulated sodium reabsorption 0 0.52173913 0.45971686 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Aldosterone-regulated sodium reabsorption 0 -0.440711462 0 kegg kegg NA NA no no no no no no GnRH secretion Aldosterone-regulated sodium reabsorption 0.77826087 0.643280632 0.614414414 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Aldosterone-regulated sodium reabsorption 0.607826087 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Aldosterone-regulated sodium reabsorption 0.415652174 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Aldosterone-regulated sodium reabsorption 0 0 0.492406692 kegg kegg NA NA no no no no no no Histidine metabolism Aldosterone-regulated sodium reabsorption -0.536521739 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Aldosterone-regulated sodium reabsorption 0.422608696 0 0 kegg kegg NA NA no no no no no no Insulin resistance Aldosterone-regulated sodium reabsorption 0.488695652 0.505928854 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Aldosterone-regulated sodium reabsorption -0.423478261 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Aldosterone-regulated sodium reabsorption 0.56 0 0 kegg kegg NA NA no no up no no no MAPK signaling pathway Aldosterone-regulated sodium reabsorption 0 0 0.579150579 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Aldosterone-regulated sodium reabsorption 0 -0.556324111 0 kegg kegg NA NA no no no no no no Mismatch repair Aldosterone-regulated sodium reabsorption -0.534782609 -0.527667984 0 kegg kegg NA NA no no no no no no Mitophagy - animal Aldosterone-regulated sodium reabsorption 0 0 -0.566537967 kegg kegg NA NA no no no no no no Necroptosis Aldosterone-regulated sodium reabsorption 0 0 -0.406177606 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Aldosterone-regulated sodium reabsorption 0.693043478 0.639328063 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Aldosterone-regulated sodium reabsorption 0 0.481225296 0.42007722 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Aldosterone-regulated sodium reabsorption 0 0 -0.428056628 kegg kegg NA NA no no no no no no Non-homologous end-joining Aldosterone-regulated sodium reabsorption -0.519130435 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Aldosterone-regulated sodium reabsorption 0 0.438735178 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Aldosterone-regulated sodium reabsorption 0 -0.548418972 0 kegg kegg NA NA no no no no no no One carbon pool by folate Aldosterone-regulated sodium reabsorption 0 -0.461462451 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Aldosterone-regulated sodium reabsorption 0 0.454545455 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Aldosterone-regulated sodium reabsorption -0.58173913 -0.503952569 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Aldosterone-regulated sodium reabsorption -0.614782609 -0.552371542 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Aldosterone-regulated sodium reabsorption 0.510434783 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Aldosterone-regulated sodium reabsorption 0.463478261 0 0.408236808 kegg kegg NA NA no up up no no no Phototransduction Aldosterone-regulated sodium reabsorption 0 -0.416996047 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Aldosterone-regulated sodium reabsorption 0 0 -0.458429858 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Aldosterone-regulated sodium reabsorption -0.580869565 -0.449604743 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Aldosterone-regulated sodium reabsorption 0.570434783 0 0.532561133 kegg kegg NA NA no no no no no no Prolactin signaling pathway Aldosterone-regulated sodium reabsorption 0.796521739 0.503952569 0.515830116 kegg kegg NA NA no no no no no no Proteasome Aldosterone-regulated sodium reabsorption 0 -0.42687747 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Aldosterone-regulated sodium reabsorption 0 0 -0.422393822 kegg kegg NA NA no no no no no no Pyrimidine metabolism Aldosterone-regulated sodium reabsorption -0.586086957 -0.427865613 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Aldosterone-regulated sodium reabsorption -0.41826087 -0.468379447 0 kegg kegg NA NA no no no no no no Ras signaling pathway Aldosterone-regulated sodium reabsorption 0.444347826 0 0 yes kegg kegg NA NA no up up no no no Relaxin signaling pathway Aldosterone-regulated sodium reabsorption 0.46 0 0 kegg kegg NA NA no no no no no no Renin secretion Aldosterone-regulated sodium reabsorption 0 -0.43972332 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Aldosterone-regulated sodium reabsorption 0 0 0.446846847 kegg kegg NA NA no no no no no no Retinol metabolism Aldosterone-regulated sodium reabsorption 0 -0.563241107 0 kegg kegg NA NA no no no no no no Ribosome Aldosterone-regulated sodium reabsorption 0 0 -0.553410553 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Aldosterone-regulated sodium reabsorption 0.456521739 0.508893281 0 kegg kegg NA NA no no no no no no RNA polymerase Aldosterone-regulated sodium reabsorption 0 -0.433794466 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Aldosterone-regulated sodium reabsorption 0.732173913 0.506916996 0.549034749 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Aldosterone-regulated sodium reabsorption 0.880869565 0.758893281 0.646589447 kegg kegg NA NA no no no no no no Steroid biosynthesis Aldosterone-regulated sodium reabsorption 0 -0.561264822 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Aldosterone-regulated sodium reabsorption -0.582608696 -0.495059289 0 kegg kegg NA NA no no no no no no Sulfur metabolism Aldosterone-regulated sodium reabsorption -0.592173913 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Aldosterone-regulated sodium reabsorption -0.422608696 -0.497035573 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Aldosterone-regulated sodium reabsorption 0.428695652 0 0.473873874 kegg kegg NA NA no no no no no no Taste transduction Aldosterone-regulated sodium reabsorption 0 -0.618577075 0 kegg kegg NA NA no no up no no no Thermogenesis Aldosterone-regulated sodium reabsorption 0 0 -0.465379665 kegg kegg NA NA no no no no no no Thiamine metabolism Aldosterone-regulated sodium reabsorption -0.440869565 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Aldosterone-regulated sodium reabsorption 0 0 -0.493436293 kegg kegg NA NA no no no no no no Tight junction Aldosterone-regulated sodium reabsorption -0.515652174 0 -0.428571429 kegg kegg NA NA no no no no no no TNF signaling pathway Aldosterone-regulated sodium reabsorption 0.606086957 0.579051383 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Aldosterone-regulated sodium reabsorption 0.617391304 0.514822134 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Aldosterone-regulated sodium reabsorption -0.642608696 -0.458498024 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Aldosterone-regulated sodium reabsorption 0.803478261 0.695652174 0.674131274 kegg kegg NA NA no no no no no no Tyrosine metabolism Aldosterone-regulated sodium reabsorption -0.58 -0.567193676 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Aldosterone-regulated sodium reabsorption -0.747826087 -0.583003953 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Aldosterone-regulated sodium reabsorption 0 0 -0.596653797 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Aldosterone-regulated sodium reabsorption -0.633043478 -0.598814229 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Aldosterone-regulated sodium reabsorption 0.874782609 0.803359684 0.651737452 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Aldosterone-regulated sodium reabsorption 0.443478261 0 -0.412355212 kegg kegg NA NA no no no no no no Parabacteroides Alistipes 0 0.414475422 0 Genus Genus 4.19E-05 0.0114 no up up no up no 2-Oxocarboxylic acid metabolism Allograft rejection 0.462608696 0 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Allograft rejection 0 -0.43972332 0 kegg kegg NA NA no no up no no no Aldosterone synthesis and secretion Allograft rejection 0 -0.612648221 0 kegg kegg NA NA no up up no no no Alzheimer disease Allograft rejection -0.507826087 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Allograft rejection 0 0 -0.411840412 kegg kegg NA NA no no no no no no Amphetamine addiction Allograft rejection -0.426086957 -0.684782609 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Allograft rejection 0 -0.665019763 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Allograft rejection -0.455652174 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Allograft rejection 0 0 -0.455598456 kegg kegg NA NA no no no no no no Antigen processing and presentation Allograft rejection 0.469565217 0.533596838 0.645817246 kegg kegg NA NA no no no no no no Apelin signaling pathway Allograft rejection -0.459130435 0 0 kegg kegg NA NA no no no no no no Apoptosis Allograft rejection 0 0.710474308 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Allograft rejection 0 0 -0.555469755 kegg kegg NA NA no no no no no no Asthma Allograft rejection 0.448695652 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Allograft rejection 1 1 1 kegg kegg NA NA no no no no no no Autophagy - other Allograft rejection -0.580869565 0 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Allograft rejection 0 0.472332016 0 kegg kegg NA NA no no no no no no Bacteroides Allograft rejection 0.433043478 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Allograft rejection -0.592173913 -0.584980237 -0.535649936 kegg kegg NA NA no no no no no no Base excision repair Allograft rejection 0 -0.530632411 -0.436550837 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Allograft rejection 0.570434783 0.587944664 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Allograft rejection 0 -0.843873518 0 kegg kegg NA NA no no no no no no Butyricicoccus Allograft rejection 0 0 0.471212756 butyrate-producing Genus kegg 0.852 NA no no no no no no C-type lectin receptor signaling pathway Allograft rejection 0 0.523715415 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Allograft rejection -0.452173913 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Allograft rejection 0.477391304 0.475296443 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Allograft rejection -0.428695652 0 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Allograft rejection 0.957391304 0.960474308 0.942599743 kegg kegg NA NA no no no no no no Cell cycle Allograft rejection -0.607826087 -0.612648221 0 kegg kegg NA NA no no no no no no Cellular senescence Allograft rejection 0.830434783 0.935770751 0.886486486 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Allograft rejection 0 0 -0.444530245 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Allograft rejection 0 0.528656126 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Allograft rejection -0.535652174 -0.588932806 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Allograft rejection 0 0.451581028 0.466666667 kegg kegg NA NA no no no no no no Cholesterol metabolism Allograft rejection 0 0.708498024 0 yes kegg kegg NA NA no no up no no no Circadian rhythm Allograft rejection -0.499130435 -0.504940711 0 kegg kegg NA NA no no no no no no Cocaine addiction Allograft rejection 0 -0.522727273 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Allograft rejection 0.528695652 0.57312253 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Allograft rejection 0 -0.627470356 0 kegg kegg NA NA no no up no no no Cushing syndrome Allograft rejection 0 -0.698616601 0 kegg kegg NA NA no no up no no no Cytosolic DNA-sensing pathway Allograft rejection 0 0 0.47979408 kegg kegg NA NA no no no no no no DNA replication Allograft rejection 0 -0.418972332 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Allograft rejection -0.44 -0.524703557 0 kegg kegg NA NA no up no no no no Endocrine and other factor-regulated calcium reabsorption Allograft rejection 0 -0.468379447 0 kegg kegg NA NA no no no no no no Endocrine resistance Allograft rejection 0 -0.563241107 0 kegg kegg NA NA no no no no no no Endocytosis Allograft rejection 0.833043478 0.944664032 0.909137709 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Allograft rejection 0 0.577075099 0.542084942 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Allograft rejection 0.475652174 0.544466403 0.736422136 kegg kegg NA NA no no no no no no Estrogen signaling pathway Allograft rejection -0.426956522 -0.490118577 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Allograft rejection -0.502608696 -0.698616601 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Allograft rejection 0 -0.563241107 -0.463320463 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Allograft rejection 0 0.576086957 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Allograft rejection 0 0.546442688 0 kegg kegg NA NA no no no no no no Folate biosynthesis Allograft rejection -0.459130435 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Allograft rejection 0 0 -0.534877735 kegg kegg NA NA no no no no no no Glucagon signaling pathway Allograft rejection 0 -0.62944664 0 kegg kegg NA NA no no no no no no Glutathione metabolism Allograft rejection 0 -0.540513834 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Allograft rejection -0.487826087 -0.472332016 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Allograft rejection 0 -0.780632411 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Allograft rejection 0.424347826 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Allograft rejection 0 0.624505929 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Allograft rejection 0 -0.752964427 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Allograft rejection 0 -0.553359684 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Allograft rejection 0 -0.446640316 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Allograft rejection 0 0.53458498 0.68957529 kegg kegg NA NA no no no no no no Homologous recombination Allograft rejection 0 -0.505928854 -0.532818533 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Allograft rejection 0.42173913 0.535573123 0.682625483 kegg kegg NA NA no no dn no no no Human immunodeficiency virus 1 infection Allograft rejection 0 0.53458498 0.665894466 kegg kegg NA NA no no no no no no Human papillomavirus infection Allograft rejection 0.839130435 0.90513834 0.841698842 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Allograft rejection 0.471304348 0.519762846 0.714543115 kegg kegg NA NA no no no no no no Huntington disease Allograft rejection -0.474782609 0 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Allograft rejection 0 0.563241107 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Allograft rejection 0 -0.421936759 0 kegg kegg NA NA no no no no no no Influenza A Allograft rejection 0.605217391 0.770750988 0.544401544 kegg kegg NA NA no no no no no no Insulin resistance Allograft rejection -0.462608696 0 0 kegg kegg NA NA no no no no no no Insulin secretion Allograft rejection 0 -0.570158103 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Allograft rejection -0.450434783 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Allograft rejection 0.511304348 0.506916996 0.413127413 kegg kegg NA NA no no no no no no Long-term potentiation Allograft rejection -0.473913043 0 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Allograft rejection 0 -0.471343874 0 kegg kegg NA NA no no no no no no Lysosome Allograft rejection 0 0.704545455 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Allograft rejection -0.595652174 0 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Allograft rejection 0 -0.513833992 0 kegg kegg NA NA no up no no no no Measles Allograft rejection -0.502608696 0 0 kegg kegg NA NA no no no no no no Mismatch repair Allograft rejection 0 -0.545454545 0 kegg kegg NA NA no no no no no no Mitophagy - animal Allograft rejection 0 -0.491106719 0 kegg kegg NA NA no no no no no no Morphine addiction Allograft rejection 0 -0.428853755 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Allograft rejection -0.593043478 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Allograft rejection 0.822608696 0.95256917 0.8998713 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Allograft rejection 0 0.615612648 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Allograft rejection 0 0.492094862 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Allograft rejection 0.406086957 0.612648221 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Allograft rejection 0 0.490118577 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Allograft rejection -0.504347826 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Allograft rejection 0 -0.589920949 -0.535907336 kegg kegg NA NA no no no no no no One carbon pool by folate Allograft rejection 0 -0.546442688 0 kegg kegg NA NA no no no no no no Oocyte meiosis Allograft rejection -0.542608696 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Allograft rejection 0 0.588932806 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Allograft rejection -0.529565217 -0.53458498 -0.400514801 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Allograft rejection 0 -0.457509881 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Allograft rejection -0.460869565 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Allograft rejection -0.511304348 -0.491106719 -0.543886744 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Allograft rejection -0.406086957 -0.434782609 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Allograft rejection 0 0.7756917 0.474646075 kegg kegg NA NA no no no no no no Pathways in cancer Allograft rejection -0.551304348 0 -0.441698842 kegg kegg NA NA no no no no no no Pentose phosphate pathway Allograft rejection 0.453043478 0.663043478 0 kegg kegg NA NA no no no no no no Pertussis Allograft rejection 0 0.649209486 0 kegg kegg NA NA no no dn no no no Phagosome Allograft rejection 0.895652174 0.916007905 0.814929215 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Allograft rejection -0.53826087 0 0 yes kegg kegg NA NA no up up no no no Platinum drug resistance Allograft rejection 0 0 -0.578635779 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Allograft rejection 0 -0.745059289 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Allograft rejection 0 0.457509881 0 kegg kegg NA NA no no no no no no Prion disease Allograft rejection -0.459130435 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Allograft rejection -0.429565217 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Allograft rejection 0 0.455533597 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Allograft rejection 0.426086957 0.456521739 0 yes kegg kegg NA NA no up up no no no Protein export Allograft rejection -0.557391304 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Allograft rejection 0 -0.471343874 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Allograft rejection 0 0 -0.402831403 kegg kegg NA NA no no no no no no Purine metabolism Allograft rejection 0 -0.751976285 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Allograft rejection 0 -0.423913043 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Allograft rejection 0 -0.431818182 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Allograft rejection 0 0.677865613 0 kegg kegg NA NA no no no no no no Retinol metabolism Allograft rejection 0 -0.414031621 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Allograft rejection -0.517391304 0 0 kegg kegg NA NA no no up no no no Rheumatoid arthritis Allograft rejection 0.647826087 0.739130435 0.415444015 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Allograft rejection -0.432173913 -0.536561265 0 kegg kegg NA NA no no no no no no RNA degradation Allograft rejection -0.503478261 0 0 kegg kegg NA NA no no no no no no RNA polymerase Allograft rejection -0.46173913 -0.570158103 0 kegg kegg NA NA no no no no no no Ruminococcus Allograft rejection 0 0 0.405662806 acetate-producing Genus kegg 0.335 NA no no no no no no Salmonella infection Allograft rejection 0 0.706521739 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Allograft rejection -0.53826087 -0.531620553 -0.468725869 kegg kegg NA NA no no no no no no Sphingolipid metabolism Allograft rejection 0 0.445652174 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Allograft rejection 0 0.713438735 0 kegg kegg NA NA no no no no no no Spliceosome Allograft rejection -0.415652174 0 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Allograft rejection 0.569565217 0.731225296 0 kegg kegg NA NA up no no no no no Steroid biosynthesis Allograft rejection -0.605217391 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Allograft rejection 0 0.462450593 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Allograft rejection 0 -0.589920949 -0.425740026 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Allograft rejection 0.405217391 0.687747036 0 kegg kegg NA NA no no no no no no Taste transduction Allograft rejection -0.659130435 -0.586956522 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Allograft rejection -0.414782609 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Allograft rejection -0.695652174 0 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Allograft rejection 0 0.570158103 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Allograft rejection 0 0.540513834 0 kegg kegg NA NA no no no no no no Thermogenesis Allograft rejection -0.436521739 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Allograft rejection 0 -0.592885375 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Allograft rejection 0 -0.496047431 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Allograft rejection 0 0.48715415 0.462548263 yes kegg kegg NA NA no no no no no no Toxoplasmosis Allograft rejection 0 0.563241107 0 kegg kegg NA NA no no no no no no Tuberculosis Allograft rejection 0.476521739 0.698616601 0 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Allograft rejection 1 0.999011858 0.999485199 kegg kegg NA NA no no no no no no Tyrosine metabolism Allograft rejection 0 -0.449604743 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Allograft rejection 0 -0.449604743 -0.424967825 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Allograft rejection 0 -0.555335968 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Allograft rejection 0 -0.425889328 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Allograft rejection 0.803478261 0.916996047 0.856370656 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Allograft rejection -0.532173913 0 0 kegg kegg NA NA no no no no no no Yersinia infection Allograft rejection 0 0.713438735 0.407207207 kegg kegg NA NA no no no no no no 14:0+blood ALP+clinic 0 -0.603571429 0 yes serum_fattyacid clinic 0.00572 0.157 up no dn no no no 15-HETE+blood ALP+clinic 0.708067693 0 0 serum_ARA clinic 0.819 0.157 no no no no no no 16:0/16:1-PC+blood ALP+clinic 0 -0.657142857 0 serum_phospholipids clinic 0.00283 0.157 up up no no no no 16:0/18:2-PI+blood ALP+clinic 0 -0.542857143 0.410769231 serum_phospholipids clinic 0.269 0.157 no no no no no no 16:0/20:4-PC+blood ALP+clinic 0 0.610714286 0 serum_phospholipids clinic 0.0262 0.157 no up no no no no 16:0/22:6-PC+blood ALP+clinic 0 0.592857143 0 serum_phospholipids clinic 4.53E-05 0.157 no up up no no no 16:1/18:2-PG+blood ALP+clinic 0 -0.696428571 0 serum_phospholipids clinic 1.40E-08 0.157 no up up no no no 18:0/18:0-PC+blood ALP+clinic -0.616099071 0 0 serum_phospholipids clinic 0.426 0.157 no no no no no no 18:0/18:0-PS+blood ALP+clinic -0.494324045 0 0 serum_phospholipids clinic 0.00617 0.157 no up no no no no 18:0/18:1-PC+blood ALP+clinic -0.642930857 0 0 serum_phospholipids clinic 0.393 0.157 no no no no no no 18:0/18:1-PE+blood ALP+clinic 0 -0.621428571 -0.406153846 serum_phospholipids clinic 0.00716 0.157 up up no no no no 18:0/20:4-PC+blood ALP+clinic 0 0.817857143 0 serum_phospholipids clinic 0.454 0.157 no no no no no no 18:0/20:5-PC+blood ALP+clinic 0 0.746428571 0 serum_phospholipids clinic 0.17 0.157 no no no no no no 18:1/18:1-PE+blood ALP+clinic 0 -0.678571429 0 serum_phospholipids clinic 1.03E-05 0.157 up up no no no no 18:1/18:2-PG+blood ALP+clinic 0 -0.535714286 0 serum_phospholipids clinic 5.58E-07 0.157 no up up no no no 18:1/20:4-PC+blood ALP+clinic 0 0.710714286 0 serum_phospholipids clinic 0.582 0.157 no no no no no no 20:0/20:5-PC+blood ALP+clinic 0 0.635714286 0 serum_phospholipids clinic 0.882 0.157 no no no no no no 20:1-LPA+blood ALP+clinic 0 -0.517857143 0 serum_phospholipids clinic 0.0187 0.157 dn dn no no no no 20:1+blood ALP+clinic 0.486068111 0 0 yes serum_fattyacid clinic 2.56E-05 0.157 dn dn dn no no no 20:3/16:0-PC+blood ALP+clinic 0 0.596428571 0 serum_phospholipids clinic 0.00405 0.157 no up up no no no 20:3/18:0-PC+blood ALP+clinic 0 0.617857143 0 serum_phospholipids clinic 0.296 0.157 no no no no no no 20:4-LPC+blood ALP+clinic 0 0.539285714 0 serum_phospholipids clinic 0.949 0.157 no no no no no no 20:4n6+blood ALP+clinic 0 0.610714286 0 serum_fattyacid clinic 0.133 0.157 no no no no no no 20:5/18:0-PC+blood ALP+clinic 0 0.532142857 0 serum_phospholipids clinic 3.97E-06 0.157 no up up no no no 4-hydroxybenzoic acid+urine ALP+clinic 0 0.490196078 0 urine_cometabolism clinic 0.52 0.157 no no no no no no 9-HODE+blood ALP+clinic 0.475748194 0 0 serum_ARA clinic 0.297 0.157 no no no no no no Apelin signaling pathway ALP+clinic 0 0.537662338 0 kegg clinic NA 0.157 no no no no no no Bacteroides ALP+clinic 0 0.526821005 0 LPS-producing Genus clinic 0.000267 0.157 dn dn up no no no Butyricimonas ALP+clinic 0 0.480882312 0 butyrate-producing Genus clinic 0.17 0.157 no no no no no no C-peptide ALP+clinic 0 -0.428571429 0 DM-assocaited hormones clinic 0.228 0.157 no no no no no no Cholinergic synapse ALP+clinic 0 0.493506494 0 kegg clinic NA 0.157 no no no no no no Collinsella ALP+clinic -0.512478395 0 0 Genus clinic 0.128 0.157 no no no no no no Coronavirus disease - COVID-19 ALP+clinic 0 0.436363636 0 kegg clinic NA 0.157 no no no no no no d18:1-18:0-SM+blood ALP+clinic 0 0.521428571 0 serum_phospholipids clinic 0.97 0.157 no no no no no no d18:1-20:0-SM+blood ALP+clinic 0 0.696428571 0 serum_phospholipids clinic 0.933 0.157 no no no no no no d18:1-20:1-SM+blood ALP+clinic 0.490196078 0.675 0 serum_phospholipids clinic 0.0992 0.157 no no no no no no d18:1-24:1-SM+blood ALP+clinic 0 0.625 0 serum_phospholipids clinic 0.0123 0.157 no dn dn no no no DCA+blood ALP+clinic 0 0.525 0 serum_bileacids clinic 0.122 0.157 no no no no no no EGFR tyrosine kinase inhibitor resistance ALP+clinic 0 0.536363636 0 kegg clinic NA 0.157 no no no no no no EPA+blood ALP+clinic 0 0.557142857 0 serum_ARA clinic 0.212 0.157 no no no no no no Ethanolamine+blood ALP+clinic -0.494324045 0 0 serum_aminoacids clinic 0.122 0.157 up no no no no no GDCA+stool ALP+clinic 0.550404858 0 0 stool_bileacids clinic 0.656 0.157 no no no no no no GLCA+blood ALP+clinic -0.481933139 0 0 serum_bileacids clinic 0.319 0.157 no no no no no no HIF-1 signaling pathway ALP+clinic 0 0.485714286 0 kegg clinic NA 0.157 no no no no no no Indole-3-Acetic acid+urine ALP+clinic 0 0 -0.457692308 urine_cometabolism clinic 0.657 0.157 no no no no no no Insulin signaling pathway ALP+clinic 0 0.501298701 0 kegg clinic NA 0.157 no no no no no no L-Alanine+blood ALP+clinic 0 0 0.490769231 yes serum_aminoacids clinic 0.00138 0.157 up up no no no no L-Aspartic acid+blood ALP+clinic 0 0 0.510769231 yes serum_aminoacids clinic 0.0226 0.157 up up no no no no L-Glutamic acid+blood ALP+clinic 0 0 0.410769231 yes serum_aminoacids clinic 6.20E-05 0.157 up up no no no no L-Isoleucine+blood ALP+clinic -0.601651187 0 0 yes serum_aminoacids clinic 5.47E-06 0.157 up up no no no no L-Leucine+blood ALP+clinic -0.477812178 0 0 yes serum_aminoacids clinic 3.22E-05 0.157 up up no no no no L-Methionine+blood ALP+clinic 0 0 -0.466153846 serum_aminoacids clinic 0.626 0.157 no no no no no no L-Proline+blood ALP+clinic 0 -0.517857143 0 yes serum_aminoacids clinic 0.00265 0.157 up up no no no no Legionellosis ALP+clinic 0 0.533766234 0 kegg clinic NA 0.157 no no no no no no Leishmaniasis ALP+clinic 0 0.457142857 0 kegg clinic NA 0.157 no no no no no no mTOR signaling pathway ALP+clinic 0 0.490909091 0 kegg clinic NA 0.157 no no no no no no PI3K-Akt signaling pathway ALP+clinic 0 0.511688312 0 yes kegg clinic NA 0.157 no up up no no no Proteoglycans in cancer ALP+clinic 0 0.496103896 0 kegg clinic NA 0.157 no no no no no no Ribosome ALP+clinic 0 0.44025974 0 kegg clinic NA 0.157 no no no no no no RNA transport ALP+clinic 0 0.536363636 0 kegg clinic NA 0.157 no no no no no no TCA+stool ALP+clinic 0 -0.751710379 0 stool_bileacids clinic 0.458 0.157 no no no no no no TXB2+blood ALP+clinic 0 0.558816169 0 yes serum_ARA clinic 0.0644 0.157 dn no no no no no Valine+blood ALP+clinic -0.486068111 0 0 yes serum_aminoacids clinic 1.22E-06 0.157 up up no no no no "Alanine, aspartate and glutamate metabolism" alpha-Linolenic acid metabolism 0 0.654150198 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism alpha-Linolenic acid metabolism 0.719130435 0.504940711 0.637837838 kegg kegg NA NA no no no no no no Arginine and proline metabolism alpha-Linolenic acid metabolism 0.454782609 0.568181818 0 kegg kegg NA NA no up no no no no Arginine biosynthesis alpha-Linolenic acid metabolism 0 0.613636364 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism alpha-Linolenic acid metabolism 0 0 0.616216216 kegg kegg NA NA no no no no no no beta-Alanine metabolism alpha-Linolenic acid metabolism 0.799130435 0 0.558815959 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) alpha-Linolenic acid metabolism 0.495652174 0 0.511711712 kegg kegg NA NA no no no no no no Ether lipid metabolism alpha-Linolenic acid metabolism -0.49826087 0 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis alpha-Linolenic acid metabolism 0 0.684782609 0 kegg kegg NA NA no no no no no no Fatty acid degradation alpha-Linolenic acid metabolism 0.580869565 0.701581028 0.62033462 kegg kegg NA NA no no no no no no Fatty acid elongation alpha-Linolenic acid metabolism 0.515652174 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism alpha-Linolenic acid metabolism 0.802608696 0.555335968 0.564736165 kegg kegg NA NA no no no no no no Galactose metabolism alpha-Linolenic acid metabolism 0.780869565 0.802371542 0.571171171 kegg kegg NA NA no no no no no no Glutathione metabolism alpha-Linolenic acid metabolism 0 -0.633399209 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism alpha-Linolenic acid metabolism 0 0.638339921 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism alpha-Linolenic acid metabolism 0 0.455533597 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" alpha-Linolenic acid metabolism 0 0 -0.457915058 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis alpha-Linolenic acid metabolism 0.74 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate alpha-Linolenic acid metabolism 0 0.541501976 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin alpha-Linolenic acid metabolism 0.493913043 0 0.505019305 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate alpha-Linolenic acid metabolism -0.640869565 -0.545454545 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation alpha-Linolenic acid metabolism 0 0 0.590990991 kegg kegg NA NA no no up no no no Histidine metabolism alpha-Linolenic acid metabolism 0.659130435 0.477272727 0.624710425 kegg kegg NA NA no no no no no no Inositol phosphate metabolism alpha-Linolenic acid metabolism 0 0.424901186 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism alpha-Linolenic acid metabolism 0.508695652 0 0.442728443 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis alpha-Linolenic acid metabolism -0.511304348 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis alpha-Linolenic acid metabolism 0 -0.590909091 0 kegg kegg NA NA no no no no no no Other glycan degradation alpha-Linolenic acid metabolism 0.547826087 0.503952569 0.62033462 kegg kegg NA NA no no no no no no Oxidative phosphorylation alpha-Linolenic acid metabolism -0.589565217 -0.752964427 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway alpha-Linolenic acid metabolism 0.55826087 0.424901186 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism alpha-Linolenic acid metabolism 0.562608696 0 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis alpha-Linolenic acid metabolism 0.416521739 0 0.437065637 kegg kegg NA NA no no no no no no Purine metabolism alpha-Linolenic acid metabolism 0 0 -0.435778636 kegg kegg NA NA no no no no no no Pyrimidine metabolism alpha-Linolenic acid metabolism 0.625217391 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism alpha-Linolenic acid metabolism 0 0 0.43037323 kegg kegg NA NA no no no no no no Starch and sucrose metabolism alpha-Linolenic acid metabolism 0.688695652 0.804347826 0.538481338 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis alpha-Linolenic acid metabolism 0.486956522 0 0.482110682 kegg kegg NA NA no no no no no no Tryptophan metabolism alpha-Linolenic acid metabolism 0.664347826 0 0.455598456 kegg kegg NA NA no up no no no no Tyrosine metabolism alpha-Linolenic acid metabolism 0.486086957 0 0.418018018 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis alpha-Linolenic acid metabolism 0.475652174 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" alpha-Linolenic acid metabolism 0.53826087 0 0.473359073 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis alpha-Linolenic acid metabolism 0 -0.516798419 0 kegg kegg NA NA no no no no no no 12-ketoDCA+blood ALT+clinic 0 0 -0.438172789 serum_bileacids clinic 0.517 0.00654 no no no up up no 13-HODE+blood ALT+clinic 0 0 -0.413076923 serum_ARA clinic 0.32 0.00654 no no no up up no 16:0-LPC+blood ALT+clinic 0 0.575 0 serum_phospholipids clinic 0.00456 0.00654 up up no up up no 16:0/16:0-PC+blood ALT+clinic 0 0 -0.467692308 serum_phospholipids clinic 0.00079 0.00654 no up up up up no 16:0/18:3-PC+blood ALT+clinic -0.653250774 0 0 serum_phospholipids clinic 0.00216 0.00654 no up up up up no 16:1/18:2-PG+blood ALT+clinic 0 0.675 0 serum_phospholipids clinic 1.40E-08 0.00654 no up up up up no 16:1+blood ALT+clinic 0 0 -0.433076923 yes serum_fattyacid clinic 0.0186 0.00654 no no dn up up no 18:2/20:4-PC+blood ALT+clinic 0 0 0.443076923 serum_phospholipids clinic 0.0145 0.00654 no no up up up no 18:2n6c+blood ALT+clinic 0 0 -0.422307692 serum_fattyacid clinic 0.15 0.00654 no no no up up no 18:3n3+blood ALT+clinic -0.601651187 0 -0.586153846 serum_fattyacid clinic 0.291 0.00654 no no no up up no 2-hydroxyhippuric acid+urine ALT+clinic 0.628482972 0 0 urine_cometabolism clinic 0.215 0.00654 no no no up up no 20:1-LPA+blood ALT+clinic -0.521155831 0 0 serum_phospholipids clinic 0.0187 0.00654 dn dn no up up no 3-(3-Hydroxyphenyl)propanoic acid+stool ALT+clinic -0.611764706 0 0 stool_cometabolism clinic 0.33 0.00654 no no no up up no 9-HODE+blood ALT+clinic -0.576883385 0 0 serum_ARA clinic 0.297 0.00654 no no no up up no Adipocytokine signaling pathway ALT+clinic 0.486166008 0 0 kegg clinic NA 0.00654 no no no up up no Cytokine-cytokine receptor interaction ALT+clinic 0 -0.438961039 0 kegg clinic NA 0.00654 no no no up up no d18:1-20:0-SM+blood ALT+clinic -0.469556244 0 0 serum_phospholipids clinic 0.933 0.00654 no no no up up no DHA+blood ALT+clinic -0.543859649 0 0 serum_ARA clinic 0.872 0.00654 no no no up up no Ferroptosis ALT+clinic 0.428571429 0 0 kegg clinic NA 0.00654 no no no up up no GCA+blood ALT+clinic 0.488132095 0 0 yes serum_bileacids clinic 0.16 0.00654 no no no up up no HCA+stool ALT+clinic 0 0 0.472614342 stool_bileacids clinic 0.155 0.00654 no no no up up no iso-DCA+blood ALT+clinic -0.574819401 0 0 serum_bileacids clinic 0.38 0.00654 no no no up up no LCA+blood ALT+clinic 0 0 -0.42853081 serum_bileacids clinic 0.884 0.00654 no no no up up no Mineral absorption ALT+clinic 0.512140034 0 0 kegg clinic NA 0.00654 no no no up up no Necroptosis ALT+clinic 0.431959345 0.466233766 0 kegg clinic NA 0.00654 no no no up up no Ras signaling pathway ALT+clinic 0 -0.468831169 0 yes kegg clinic NA 0.00654 no up up up up no Ruminococcus ALT+clinic -0.499509633 0 0 Genus clinic 0.0679 0.00654 no no dn up up no T-a-MCA+blood ALT+clinic 0 0 -0.448189785 serum_bileacids clinic 0.478 0.00654 no no no up up no 2-Oxocarboxylic acid metabolism Alzheimer disease -0.580869565 0 0 kegg kegg NA NA no no no no no no ABC transporters Alzheimer disease -0.407826087 -0.423913043 0 kegg kegg NA NA no up up no no no Adherens junction Alzheimer disease 0 0.663043478 0.48983269 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Alzheimer disease 0.749565217 0.825098814 0.483397683 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Alzheimer disease 0 -0.820158103 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Alzheimer disease -0.493043478 -0.780632411 -0.589446589 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Alzheimer disease 0.58 0.768774704 0.404890605 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Alzheimer disease -0.613913043 -0.767786561 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Alzheimer disease -0.606956522 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Alzheimer disease -0.613043478 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Alzheimer disease 0 0.461462451 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Alzheimer disease 0 0.766798419 0 kegg kegg NA NA no no no no no no Apoptosis Alzheimer disease -0.467826087 -0.583992095 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Alzheimer disease 0 -0.46541502 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Alzheimer disease 0 -0.782608696 -0.597940798 kegg kegg NA NA no up no no no no Arginine biosynthesis Alzheimer disease -0.515652174 -0.727272727 -0.55984556 kegg kegg NA NA no no no no no no Autophagy - animal Alzheimer disease 0 -0.718379447 0 kegg kegg NA NA no no no no no no Axon guidance Alzheimer disease 0.516521739 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Alzheimer disease 0 -0.618577075 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Alzheimer disease -0.743478261 0 0 kegg kegg NA NA no no no no no no Bile secretion Alzheimer disease 0.42173913 0.488142292 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Alzheimer disease -0.817391304 -0.645256917 -0.495238095 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Alzheimer disease -0.426956522 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Alzheimer disease -0.613913043 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Alzheimer disease 0 -0.614624506 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Alzheimer disease 0.713913043 0.734189723 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Alzheimer disease 0.796521739 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Alzheimer disease 0 -0.470355731 0 kegg kegg NA NA no no no no no no Carbon metabolism Alzheimer disease -0.773913043 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Alzheimer disease 0.968695652 0.966403162 0.97039897 kegg kegg NA NA no no up no no no Cell adhesion molecules Alzheimer disease -0.585217391 -0.438735178 0 kegg kegg NA NA no no no no no no Cell cycle Alzheimer disease 0 0 0.473101673 kegg kegg NA NA no no no no no no Cellular senescence Alzheimer disease 0 -0.435770751 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Alzheimer disease 0 -0.645256917 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Alzheimer disease 0 -0.457509881 0 kegg kegg NA NA no no no no no no Circadian entrainment Alzheimer disease 0 0.571146245 0 kegg kegg NA NA no up up no no no Circadian rhythm Alzheimer disease 0.70173913 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Alzheimer disease 0 0.424901186 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Alzheimer disease -0.570434783 -0.645256917 0 kegg kegg NA NA no no no no no no Cushing syndrome Alzheimer disease 0.446086957 0.467391304 0 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Alzheimer disease 0 0.479249012 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Alzheimer disease 0 -0.457509881 0 kegg kegg NA NA no no no no no no DNA replication Alzheimer disease 0 0.442687747 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Alzheimer disease 0.667826087 0.717391304 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Alzheimer disease 0 0.506916996 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Alzheimer disease -0.592173913 0.585968379 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Alzheimer disease 0 0.690711462 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Alzheimer disease 0.486956522 0.792490119 0 kegg kegg NA NA no no no no no no Endocrine resistance Alzheimer disease 0.407826087 0 0 kegg kegg NA NA no no no no no no Endocytosis Alzheimer disease -0.479130435 -0.473320158 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Alzheimer disease 0 -0.434782609 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Alzheimer disease 0.695652174 0.471343874 0.448648649 kegg kegg NA NA no no no no no no Fat digestion and absorption Alzheimer disease -0.500869565 -0.62944664 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Alzheimer disease 0 -0.822134387 -0.597683398 kegg kegg NA NA no no no no no no Fatty acid degradation Alzheimer disease -0.62 -0.85770751 0 kegg kegg NA NA no no no no no no Fatty acid elongation Alzheimer disease -0.553043478 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Alzheimer disease -0.751304348 -0.830039526 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Alzheimer disease 0 -0.714426877 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Alzheimer disease -0.44 -0.653162055 -0.496010296 kegg kegg NA NA no no no no no no Focal adhesion Alzheimer disease 0 0.529644269 0.436808237 kegg kegg NA NA no up up no no no Folate biosynthesis Alzheimer disease 0 0.447628458 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Alzheimer disease 0 -0.781620553 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Alzheimer disease -0.774782609 -0.566205534 -0.534620335 kegg kegg NA NA no no no no no no GABAergic synapse Alzheimer disease 0 -0.632411067 0 kegg kegg NA NA no up up no no no Galactose metabolism Alzheimer disease -0.78173913 -0.790513834 0 kegg kegg NA NA no no no no no no Gastric acid secretion Alzheimer disease 0 0.720355731 0.43963964 kegg kegg NA NA no no no no no no Glucagon signaling pathway Alzheimer disease 0.434782609 0.760869565 0 kegg kegg NA NA no no no no no no Glutathione metabolism Alzheimer disease 0 0.71541502 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Alzheimer disease 0 -0.640316206 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Alzheimer disease -0.648695652 0.458498024 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Alzheimer disease 0 -0.751976285 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Alzheimer disease 0.499130435 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Alzheimer disease 0 -0.436758893 0 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Alzheimer disease -0.656521739 -0.730237154 -0.619305019 kegg kegg NA NA no no no no no no GnRH secretion Alzheimer disease 0 -0.415019763 0 kegg kegg NA NA no up up no no no GnRH signaling pathway Alzheimer disease 0 0.489130435 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Alzheimer disease 0.526956522 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Alzheimer disease 0 0.661067194 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Alzheimer disease 0 0.644268775 0.548262548 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Alzheimer disease 0 -0.743083004 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Alzheimer disease 0 -0.553359684 -0.52020592 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Alzheimer disease 0.545217391 0.795454545 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Alzheimer disease 0 -0.485177866 0 kegg kegg NA NA no no no no no no Insulin resistance Alzheimer disease 0 -0.552371542 0 kegg kegg NA NA no no no no no no Insulin secretion Alzheimer disease 0 0.536561265 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Alzheimer disease 0 0.707509881 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Alzheimer disease 0 -0.764822134 0 kegg kegg NA NA no no no no no no Long-term depression Alzheimer disease 0.533043478 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Alzheimer disease 0.439130435 0 0.464864865 kegg kegg NA NA no no up no no no Lysosome Alzheimer disease 0 0 -0.402574003 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Alzheimer disease 0.444347826 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Alzheimer disease 0 -0.686758893 0 kegg kegg NA NA no no no no no no Melanogenesis Alzheimer disease 0.5 0.835968379 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Alzheimer disease 0 0.458498024 0 kegg kegg NA NA no no no no no no Mineral absorption Alzheimer disease 0.407826087 0.610671937 0 kegg kegg NA NA no no no no no no Mitophagy - animal Alzheimer disease 0.52 0.821146245 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Alzheimer disease 0.74173913 0.656126482 0.476447876 kegg kegg NA NA no no no no no no mTOR signaling pathway Alzheimer disease 0 0.68972332 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Alzheimer disease 0 -0.415019763 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Alzheimer disease 0 0.56027668 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Alzheimer disease -0.488695652 -0.424901186 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Alzheimer disease 0 -0.511857708 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Alzheimer disease 0.554782609 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Alzheimer disease -0.486086957 -0.532608696 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Alzheimer disease 0 -0.730237154 -0.418790219 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Alzheimer disease 0 -0.761857708 -0.544658945 kegg kegg NA NA no no no no no no Nitrogen metabolism Alzheimer disease -0.449565217 -0.618577075 -0.493436293 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Alzheimer disease 0 -0.759881423 -0.45019305 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Alzheimer disease 0.990434783 0.961462451 0.852509653 kegg kegg NA NA no no no no no no Non-homologous end-joining Alzheimer disease -0.636521739 0 0 kegg kegg NA NA no no no no no no Olfactory transduction Alzheimer disease 0 -0.60770751 0 kegg kegg NA NA no no no no no no Oocyte meiosis Alzheimer disease 0.482608696 0.462450593 0.501673102 kegg kegg NA NA no no no no no no Oscillospira Alzheimer disease 0 -0.514822134 -0.432175032 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Alzheimer disease 0 -0.734189723 -0.468468468 kegg kegg NA NA no no no no no no Other glycan degradation Alzheimer disease 0 -0.514822134 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Alzheimer disease 0.984347826 0.991106719 0.959330759 kegg kegg NA NA no no no no no no Pancreatic secretion Alzheimer disease 0.634782609 0.72826087 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Alzheimer disease 0 -0.805335968 -0.521750322 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Alzheimer disease 0.671304348 0.805335968 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Alzheimer disease 0 0.542490119 0.430888031 kegg kegg NA NA no no no no no no Pentose phosphate pathway Alzheimer disease -0.537391304 -0.570158103 -0.554182754 kegg kegg NA NA no no no no no no Peroxisome Alzheimer disease -0.547826087 -0.747035573 -0.515315315 kegg kegg NA NA no no no no no no Phagosome Alzheimer disease -0.615652174 -0.450592885 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Alzheimer disease 0.580869565 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Alzheimer disease 0 -0.552371542 0 kegg kegg NA NA no up up no no no Phototransduction Alzheimer disease 0 0.532608696 0.501158301 kegg kegg NA NA no no no no no no Platelet activation Alzheimer disease 0 0.537549407 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Alzheimer disease 0 -0.597826087 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Alzheimer disease 0 -0.650197628 -0.407207207 kegg kegg NA NA no no no no no no Propanoate metabolism Alzheimer disease 0 0.451581028 0 kegg kegg NA NA no no no no no no Proteasome Alzheimer disease 0 0.5 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Alzheimer disease -0.64173913 -0.837944664 -0.404118404 yes kegg kegg NA NA no up up no no no Protein export Alzheimer disease 0.56 0.787549407 0.543886744 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Alzheimer disease 0 0.643280632 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Alzheimer disease 0 0.48715415 0 kegg kegg NA NA no no no no no no Purine metabolism Alzheimer disease 0 0.444664032 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Alzheimer disease -0.730434783 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Alzheimer disease 0 0.58201581 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Alzheimer disease 0 0.42687747 0 kegg kegg NA NA no no no no no no Ras signaling pathway Alzheimer disease 0 0.524703557 0.514285714 yes kegg kegg NA NA no up up no no no Relaxin signaling pathway Alzheimer disease 0.534782609 0 0 kegg kegg NA NA no no no no no no Renin secretion Alzheimer disease 0 0.804347826 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Alzheimer disease 0 -0.602766798 0 kegg kegg NA NA no no no no no no Retinol metabolism Alzheimer disease -0.46173913 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Alzheimer disease 0.831304348 0.924901186 0.828571429 kegg kegg NA NA no no up no no no Ribosome Alzheimer disease 0.704347826 0.886363636 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Alzheimer disease 0 -0.682806324 0 kegg kegg NA NA no no no no no no RNA degradation Alzheimer disease 0.689565217 0.678853755 0.436293436 kegg kegg NA NA no no no no no no RNA polymerase Alzheimer disease 0 0.549407115 0 kegg kegg NA NA no no no no no no RNA transport Alzheimer disease 0 0.583992095 0 kegg kegg NA NA no no no no no no Ruminococcus Alzheimer disease 0 0.419020601 0 Genus kegg 0.0679 NA no no dn no no no Signaling pathways regulating pluripotency of stem cells Alzheimer disease 0.626086957 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Alzheimer disease 0 -0.68083004 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Alzheimer disease 0.482608696 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Alzheimer disease -0.475652174 -0.827075099 0 kegg kegg NA NA no no no no no no Sulfur metabolism Alzheimer disease -0.449565217 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Alzheimer disease 0 -0.574110672 0 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Alzheimer disease 0 -0.507905138 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Alzheimer disease 0 -0.415019763 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Alzheimer disease 0.703478261 0.687747036 0.536422136 kegg kegg NA NA no no no no no no Th17 cell differentiation Alzheimer disease 0 -0.420948617 0 kegg kegg NA NA no no no no no no Thermogenesis Alzheimer disease 0.947826087 0.984189723 0.892921493 kegg kegg NA NA no no no no no no Thiamine metabolism Alzheimer disease 0 0.456521739 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Alzheimer disease 0 0.636363636 0.525611326 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Alzheimer disease 0 0.621541502 0 kegg kegg NA NA no no no no no no Tight junction Alzheimer disease 0 0.53458498 0 kegg kegg NA NA no no no no no no TNF signaling pathway Alzheimer disease 0 -0.550395257 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Alzheimer disease 0 -0.646245059 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Alzheimer disease -0.559130435 0 0 kegg kegg NA NA no up no no no no Type I diabetes mellitus Alzheimer disease -0.507826087 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Alzheimer disease 0 -0.612648221 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Alzheimer disease 0.519130435 0.833992095 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Alzheimer disease -0.466956522 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Alzheimer disease 0.697391304 0.853754941 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Alzheimer disease 0.536521739 0.761857708 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Alzheimer disease 0 -0.415019763 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Alzheimer disease 0.64 -0.432806324 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Alzheimer disease 0.69826087 0.649209486 0.554182754 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Amino sugar and nucleotide sugar metabolism 0.490434783 0 0.663835264 kegg kegg NA NA no no no no no no beta-Alanine metabolism Amino sugar and nucleotide sugar metabolism 0.776521739 0 0.595366795 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Amino sugar and nucleotide sugar metabolism 0.560869565 0 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Amino sugar and nucleotide sugar metabolism 0.514782609 0 0 kegg kegg NA NA no no no no no no Fatty acid degradation Amino sugar and nucleotide sugar metabolism 0.546956522 0 0.553667954 kegg kegg NA NA no no no no no no Fatty acid elongation Amino sugar and nucleotide sugar metabolism 0.612173913 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Amino sugar and nucleotide sugar metabolism 0.849565217 0.537549407 0.733590734 kegg kegg NA NA no no no no no no Galactose metabolism Amino sugar and nucleotide sugar metabolism 0.77826087 0 0.711196911 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Amino sugar and nucleotide sugar metabolism 0.82 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Amino sugar and nucleotide sugar metabolism 0.68 0.538537549 0.729214929 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Amino sugar and nucleotide sugar metabolism -0.683478261 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Amino sugar and nucleotide sugar metabolism 0.642608696 0.43083004 0 kegg kegg NA NA no no no no no no Other glycan degradation Amino sugar and nucleotide sugar metabolism 0.557391304 0.471343874 0.537709138 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Amino sugar and nucleotide sugar metabolism 0 0.482213439 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Amino sugar and nucleotide sugar metabolism -0.583478261 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Amino sugar and nucleotide sugar metabolism 0.577391304 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Amino sugar and nucleotide sugar metabolism 0.48173913 0 0.42007722 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Amino sugar and nucleotide sugar metabolism 0.692173913 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Amino sugar and nucleotide sugar metabolism 0.766956522 0.464426877 0.433976834 kegg kegg NA NA no no no no no no Selenocompound metabolism Amino sugar and nucleotide sugar metabolism 0 0.70256917 0.538996139 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Amino sugar and nucleotide sugar metabolism 0.677391304 0 0.665637066 kegg kegg NA NA no no no no no no Steroid biosynthesis Amino sugar and nucleotide sugar metabolism 0 0.437747036 0.462805663 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Amino sugar and nucleotide sugar metabolism 0.742608696 0.5 0.482368082 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Amino sugar and nucleotide sugar metabolism 0.5 0.514822134 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Amino sugar and nucleotide sugar metabolism 0.726956522 0 0.45045045 kegg kegg NA NA no up no no no no Tyrosine metabolism Amino sugar and nucleotide sugar metabolism 0.647826087 0 0.44967825 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Amino sugar and nucleotide sugar metabolism 0.744347826 0.531620553 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Amino sugar and nucleotide sugar metabolism 0.683478261 0 0.54002574 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Aminoacyl-tRNA biosynthesis 0.573913043 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Aminoacyl-tRNA biosynthesis 0.633043478 0.539525692 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Aminoacyl-tRNA biosynthesis 0 -0.48715415 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Aminoacyl-tRNA biosynthesis 0 -0.476284585 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Aminoacyl-tRNA biosynthesis 0.414782609 0.548418972 0.453539254 kegg kegg NA NA no no no no no no beta-Alanine metabolism Aminoacyl-tRNA biosynthesis 0.711304348 0.520750988 0 kegg kegg NA NA no no no no no no Butanoate metabolism Aminoacyl-tRNA biosynthesis 0.768695652 0.742094862 0.484684685 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Aminoacyl-tRNA biosynthesis 0.734782609 0.695652174 0.588674389 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Aminoacyl-tRNA biosynthesis 0.587826087 0.584980237 0.518146718 kegg kegg NA NA no no no no no no Ether lipid metabolism Aminoacyl-tRNA biosynthesis 0 0.441699605 0.439124839 kegg kegg NA NA no no no no no no Fatty acid degradation Aminoacyl-tRNA biosynthesis 0.465217391 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Aminoacyl-tRNA biosynthesis 0.51826087 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Aminoacyl-tRNA biosynthesis 0.612173913 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Aminoacyl-tRNA biosynthesis 0.610434783 0 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Aminoacyl-tRNA biosynthesis 0 0 0.522007722 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Aminoacyl-tRNA biosynthesis 0.677391304 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Aminoacyl-tRNA biosynthesis 0 0.59486166 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Aminoacyl-tRNA biosynthesis -0.529565217 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Aminoacyl-tRNA biosynthesis -0.568695652 0 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Aminoacyl-tRNA biosynthesis 0 0.73715415 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Aminoacyl-tRNA biosynthesis -0.5 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Aminoacyl-tRNA biosynthesis 0.468695652 0.462450593 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Aminoacyl-tRNA biosynthesis 0 -0.494071146 0 kegg kegg NA NA no no no no no no Histidine metabolism Aminoacyl-tRNA biosynthesis 0.513043478 0.475296443 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Aminoacyl-tRNA biosynthesis 0.448695652 0.461462451 0.481081081 kegg kegg NA NA no no no no no no Lysine degradation Aminoacyl-tRNA biosynthesis 0 0.604743083 0.482882883 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Aminoacyl-tRNA biosynthesis 0.439130435 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Aminoacyl-tRNA biosynthesis 0 0.630434783 0.691634492 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Aminoacyl-tRNA biosynthesis 0 -0.53458498 -0.447361647 kegg kegg NA NA no no no no no no Nitrogen metabolism Aminoacyl-tRNA biosynthesis 0 -0.604743083 -0.533075933 kegg kegg NA NA no no no no no no One carbon pool by folate Aminoacyl-tRNA biosynthesis 0.727826087 0.766798419 0.777091377 kegg kegg NA NA no no no no no no Other glycan degradation Aminoacyl-tRNA biosynthesis 0.422608696 0 0.417503218 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Aminoacyl-tRNA biosynthesis 0 0.514822134 0.562676963 kegg kegg NA NA no no no no no no Oxidative phosphorylation Aminoacyl-tRNA biosynthesis -0.594782609 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Aminoacyl-tRNA biosynthesis 0.452173913 0.729249012 0.53951094 kegg kegg NA NA no no no no no no Pentose phosphate pathway Aminoacyl-tRNA biosynthesis 0 -0.556324111 -0.401544402 kegg kegg NA NA no no no no no no Phenylalanine metabolism Aminoacyl-tRNA biosynthesis 0.48 0.698616601 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Aminoacyl-tRNA biosynthesis 0.703478261 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Aminoacyl-tRNA biosynthesis 0.700869565 0.508893281 0.465894466 kegg kegg NA NA no no no no no no Pyrimidine metabolism Aminoacyl-tRNA biosynthesis 0.68 0.565217391 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Aminoacyl-tRNA biosynthesis 0.749565217 0.554347826 0.494465894 kegg kegg NA NA no no no no no no Retinol metabolism Aminoacyl-tRNA biosynthesis 0.675652174 0.721343874 0.515830116 kegg kegg NA NA no no no no no no Selenocompound metabolism Aminoacyl-tRNA biosynthesis 0 0.67687747 0.734362934 kegg kegg NA NA no no no no no no Sphingolipid metabolism Aminoacyl-tRNA biosynthesis -0.454782609 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Aminoacyl-tRNA biosynthesis 0 0.56916996 0.512226512 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Aminoacyl-tRNA biosynthesis 0.43826087 0.621541502 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Aminoacyl-tRNA biosynthesis 0.715652174 0.723320158 0.601287001 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Aminoacyl-tRNA biosynthesis 0 0 0.425997426 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Aminoacyl-tRNA biosynthesis 0 0.606719368 0.547232947 kegg kegg NA NA no no no no no no Thiamine metabolism Aminoacyl-tRNA biosynthesis 0.490434783 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Aminoacyl-tRNA biosynthesis 0.72173913 0.570158103 0.417245817 kegg kegg NA NA no up no no no no Tyrosine metabolism Aminoacyl-tRNA biosynthesis 0.591304348 0.662055336 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Aminoacyl-tRNA biosynthesis 0.699130435 0.802371542 0.550836551 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Aminoacyl-tRNA biosynthesis 0.828695652 0.825098814 0.610810811 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Aminoacyl-tRNA biosynthesis 0 0.599802372 0.674646075 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Amoebiasis 0 -0.788537549 0 kegg kegg NA NA no no no no no no ABC transporters Amoebiasis -0.413913043 0 -0.518404118 kegg kegg NA NA no up up no no no Adipocytokine signaling pathway Amoebiasis 0 0.506916996 0 kegg kegg NA NA no no no no no no African trypanosomiasis Amoebiasis 0 0.593873518 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Amoebiasis 0 0.811264822 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Amoebiasis 0 0.748023715 0 kegg kegg NA NA no no no no no no Alcoholism Amoebiasis 0 0.576086957 0.474131274 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Amoebiasis 0 -0.440711462 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Amoebiasis 0 0.472332016 0 kegg kegg NA NA no no no no no no Alzheimer disease Amoebiasis 0 -0.56027668 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Amoebiasis -0.474782609 -0.700592885 -0.455083655 kegg kegg NA NA no no no no no no Amphetamine addiction Amoebiasis 0 -0.566205534 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Amoebiasis 0 -0.613636364 0 kegg kegg NA NA no no no no no no Antifolate resistance Amoebiasis 0 0 -0.516087516 kegg kegg NA NA no no no no no no Apelin signaling pathway Amoebiasis -0.48 -0.757905138 -0.614157014 kegg kegg NA NA no no no no no no Apoptosis Amoebiasis 0 0.763833992 0.513513514 kegg kegg NA NA no no no no no no Arginine and proline metabolism Amoebiasis 0 0.76284585 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Amoebiasis 0 0.778656126 0.503474903 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Amoebiasis -0.480869565 0 -0.607464607 kegg kegg NA NA no no no no no no Autophagy - animal Amoebiasis 0 0.647233202 0 kegg kegg NA NA no no no no no no Autophagy - other Amoebiasis 0 0 -0.488803089 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Amoebiasis 0 0.654150198 0 kegg kegg NA NA no no no no no no Bacteroides Amoebiasis 0 -0.468379447 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Amoebiasis 0 -0.541501976 -0.688288288 kegg kegg NA NA no no no no no no Base excision repair Amoebiasis -0.585217391 -0.490118577 -0.515572716 kegg kegg NA NA no no no no no no beta-Alanine metabolism Amoebiasis 0 -0.437747036 0 kegg kegg NA NA no no no no no no Bile secretion Amoebiasis 0.488695652 0 0.603861004 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Amoebiasis 0 0.59486166 0.553410553 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Amoebiasis 0 -0.535573123 0 kegg kegg NA NA no no no no no no Butanoate metabolism Amoebiasis 0 -0.884387352 -0.418790219 kegg kegg NA NA no no no no no no Butyricimonas Amoebiasis 0.510233077 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no C-type lectin receptor signaling pathway Amoebiasis 0 0.636363636 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Amoebiasis 0 0.56916996 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Amoebiasis 0 0.414031621 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Amoebiasis 0 -0.545454545 0 kegg kegg NA NA no no up no no no Cell cycle Amoebiasis -0.649565217 -0.697628458 -0.587902188 kegg kegg NA NA no no no no no no Cellular senescence Amoebiasis 0.499130435 0.519762846 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Amoebiasis 0 0.725296443 0 kegg kegg NA NA no no no no no no Chagas disease Amoebiasis 0.435652174 0.815217391 0.446846847 kegg kegg NA NA no no no no no no Chemokine signaling pathway Amoebiasis 0.572173913 0.75 0 kegg kegg NA NA no no no no no no Circadian rhythm Amoebiasis 0 -0.42687747 -0.630888031 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Amoebiasis -0.491304348 -0.865612648 -0.562676963 kegg kegg NA NA no no no no no no Complement and coagulation cascades Amoebiasis 0.449565217 0.677865613 0.615958816 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Amoebiasis -0.502608696 -0.862648221 -0.403861004 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Amoebiasis 0.614782609 0 0 kegg kegg NA NA no no no no no no DNA replication Amoebiasis -0.664347826 -0.84486166 -0.742084942 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Amoebiasis 0 -0.789525692 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Amoebiasis 0 -0.756916996 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Amoebiasis 0 -0.441699605 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Amoebiasis -0.446086957 -0.707509881 -0.530759331 kegg kegg NA NA no no no no no no Endocrine resistance Amoebiasis 0 0 0.418532819 kegg kegg NA NA no no no no no no Endocytosis Amoebiasis 0.489565217 0.421936759 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Amoebiasis 0.440869565 0.732213439 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Amoebiasis 0 -0.603754941 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Amoebiasis 0 -0.48715415 -0.649420849 kegg kegg NA NA no no no no no no Fanconi anemia pathway Amoebiasis -0.697391304 -0.530632411 -0.634234234 kegg kegg NA NA no no no no no no Fat digestion and absorption Amoebiasis 0 0.605731225 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Amoebiasis 0 0.738142292 0 kegg kegg NA NA no no no no no no Fatty acid elongation Amoebiasis 0 -0.43083004 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Amoebiasis 0 0.812252964 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Amoebiasis 0 0.566205534 0.578893179 kegg kegg NA NA no no no no no no Ferroptosis Amoebiasis 0 0.485177866 0 kegg kegg NA NA no no no no no no Folate biosynthesis Amoebiasis -0.733913043 -0.578063241 0 kegg kegg NA NA no no no no no no GABAergic synapse Amoebiasis 0 0.707509881 0.415958816 kegg kegg NA NA no up up no no no Gap junction Amoebiasis 0.446956522 0.468379447 0.683655084 kegg kegg NA NA no no no no no no Glucagon signaling pathway Amoebiasis 0 -0.565217391 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Amoebiasis 0.599130435 0.671936759 0.653539254 kegg kegg NA NA no up up no no no Glutathione metabolism Amoebiasis 0 -0.457509881 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Amoebiasis 0 0 -0.616473616 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Amoebiasis 0 0 -0.699356499 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Amoebiasis 0 -0.690711462 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Amoebiasis 0.497391304 0.70256917 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Amoebiasis 0 -0.541501976 -0.565250965 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Amoebiasis 0 0.477272727 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Amoebiasis 0 -0.522727273 -0.401029601 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Amoebiasis 0 0.767786561 0.447619048 kegg kegg NA NA no no no no no no GnRH secretion Amoebiasis 0 0.416996047 0 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Amoebiasis 0 0.495059289 0.45019305 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Amoebiasis 0 -0.577075099 -0.581981982 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Amoebiasis 0 -0.572134387 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Amoebiasis 0 -0.683794466 -0.456628057 kegg kegg NA NA no no no no no no Hippo signaling pathway Amoebiasis 0 -0.511857708 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Amoebiasis 0 0.622529644 0 kegg kegg NA NA no no no no no no Homologous recombination Amoebiasis -0.562608696 0 -0.562419562 kegg kegg NA NA no no no no no no Huntington disease Amoebiasis 0 -0.541501976 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Amoebiasis 0 0.699604743 0.498841699 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Amoebiasis 0 -0.489130435 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Amoebiasis 0 0 -0.561647362 kegg kegg NA NA no no no no no no Insulin resistance Amoebiasis 0 0.583003953 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Amoebiasis -0.483478261 -0.749011858 -0.622136422 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Amoebiasis 0 0.563241107 0 kegg kegg NA NA no no no no no no Legionellosis Amoebiasis 0 -0.501976285 0 kegg kegg NA NA no no no no no no Leishmaniasis Amoebiasis -0.426956522 -0.483201581 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Amoebiasis 0.426086957 0 0.555212355 kegg kegg NA NA no no no no no no Long-term depression Amoebiasis 0.53826087 0.428853755 0.57039897 kegg kegg NA NA no no no no no no Long-term potentiation Amoebiasis 0 -0.708498024 -0.428828829 kegg kegg NA NA no no up no no no Lysine degradation Amoebiasis -0.474782609 0 -0.707850708 kegg kegg NA NA no no no no no no Lysosome Amoebiasis 0 0.513833992 0 kegg kegg NA NA no no no no no no Malaria Amoebiasis 0 0.425889328 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Amoebiasis 0 0 -0.643758044 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Amoebiasis 0 0 -0.535392535 kegg kegg NA NA no up no no no no Melanogenesis Amoebiasis 0 -0.4743083 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Amoebiasis 0 -0.751976285 0 kegg kegg NA NA no no no no no no Mismatch repair Amoebiasis -0.619130435 -0.673913043 -0.412870013 kegg kegg NA NA no no no no no no mRNA surveillance pathway Amoebiasis 0 -0.637351779 -0.638352638 kegg kegg NA NA no no no no no no mTOR signaling pathway Amoebiasis -0.413913043 -0.716403162 -0.485199485 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Amoebiasis -0.474782609 -0.809288538 -0.482368082 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Amoebiasis 0.46 0.445652174 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Amoebiasis 0 0.449604743 0.482110682 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Amoebiasis 0 0.488142292 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Amoebiasis 0 0.661067194 0.617760618 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Amoebiasis 0 0.694664032 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Amoebiasis 0 0.85770751 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Amoebiasis 0.476521739 0.796442688 0.520720721 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Amoebiasis 0 0.611660079 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Amoebiasis 0 -0.419960474 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Amoebiasis 0 -0.590909091 0 kegg kegg NA NA no no no no no no Notch signaling pathway Amoebiasis 0 0 -0.627541828 kegg kegg NA NA no no no no no no Nucleotide excision repair Amoebiasis -0.682608696 -0.701581028 -0.581209781 kegg kegg NA NA no no no no no no Olfactory transduction Amoebiasis 0 0.580039526 0 kegg kegg NA NA no no no no no no One carbon pool by folate Amoebiasis -0.610434783 -0.671936759 -0.663577864 kegg kegg NA NA no no no no no no Oocyte meiosis Amoebiasis -0.409565217 -0.723320158 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Amoebiasis 0 0.668972332 0.500643501 kegg kegg NA NA no no no no no no Other glycan degradation Amoebiasis 0 0 -0.417760618 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Amoebiasis -0.533043478 0 -0.64993565 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Amoebiasis 0 0 0.628571429 kegg kegg NA NA no up up no no no Oxidative phosphorylation Amoebiasis 0 -0.532608696 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Amoebiasis 0 0 0.617503218 kegg kegg NA NA no no no no no no p53 signaling pathway Amoebiasis 0 0 -0.509137709 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Amoebiasis 0 0.70256917 0 kegg kegg NA NA no no dn no no no Parkinson disease Amoebiasis 0 -0.446640316 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Amoebiasis 0 0 0.545688546 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Amoebiasis 0 -0.469367589 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Amoebiasis -0.496521739 -0.906126482 -0.549034749 kegg kegg NA NA no no no no no no Pentose phosphate pathway Amoebiasis 0 0.612648221 0.498069498 kegg kegg NA NA no no no no no no Peroxisome Amoebiasis 0 0.541501976 0 kegg kegg NA NA no no no no no no Pertussis Amoebiasis 0.525217391 0.648221344 0.671557272 kegg kegg NA NA no no dn no no no Phagosome Amoebiasis 0.475652174 0.421936759 0.491377091 kegg kegg NA NA no no no no no no Phenylalanine metabolism Amoebiasis 0 -0.663043478 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Amoebiasis 0 -0.446640316 -0.617503218 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Amoebiasis 0.785217391 0.864624506 0.578635779 kegg kegg NA NA no up up no no no Phototransduction Amoebiasis 0 -0.532608696 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Amoebiasis -0.512173913 0 -0.532561133 yes kegg kegg NA NA no up up no no no Platelet activation Amoebiasis 0 0 0.506048906 kegg kegg NA NA no no no no no no PPAR signaling pathway Amoebiasis 0 0.570158103 0.45019305 kegg kegg NA NA no no no no no no Prevotella Amoebiasis 0 0.413635022 0 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Amoebiasis -0.58173913 -0.479249012 0 kegg kegg NA NA no no no no no no Prion disease Amoebiasis 0 -0.643280632 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Amoebiasis 0 0 -0.481853282 kegg kegg NA NA no no no no no no Prolactin signaling pathway Amoebiasis 0.429565217 0.645256917 0 kegg kegg NA NA no no no no no no Propanoate metabolism Amoebiasis -0.431304348 -0.822134387 0 kegg kegg NA NA no no no no no no Proteasome Amoebiasis 0 -0.698616601 -0.471299871 kegg kegg NA NA no no no no no no Protein export Amoebiasis -0.453043478 -0.742094862 -0.612870013 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Amoebiasis 0 -0.807312253 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Amoebiasis 0 -0.698616601 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Amoebiasis 0 -0.565217391 -0.503732304 kegg kegg NA NA no no no no no no Pyruvate metabolism Amoebiasis -0.537391304 -0.886363636 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Amoebiasis 0 0 0.521492921 kegg kegg NA NA no no no no no no Ras signaling pathway Amoebiasis 0 -0.612648221 -0.499356499 yes kegg kegg NA NA no up up no no no Regulation of lipolysis in adipocytes Amoebiasis 0.510434783 0 0.513256113 kegg kegg NA NA no no no no no no Relaxin signaling pathway Amoebiasis 0 0.66798419 0 kegg kegg NA NA no no no no no no Renin secretion Amoebiasis 0 -0.441699605 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Amoebiasis 0 0.598814229 0 kegg kegg NA NA no no no no no no Retinol metabolism Amoebiasis 0 -0.494071146 -0.492149292 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Amoebiasis 0 -0.500988142 0 kegg kegg NA NA no no up no no no Ribosome Amoebiasis 0 -0.630434783 -0.41003861 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Amoebiasis -0.543478261 -0.720355731 -0.721750322 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Amoebiasis 0 0.693675889 0 kegg kegg NA NA no no no no no no RNA degradation Amoebiasis 0 -0.811264822 -0.731016731 kegg kegg NA NA no no no no no no RNA polymerase Amoebiasis 0 -0.809288538 -0.708622909 kegg kegg NA NA no no no no no no RNA transport Amoebiasis -0.455652174 -0.757905138 0 kegg kegg NA NA no no no no no no Salivary secretion Amoebiasis 0.489565217 0 0.7003861 kegg kegg NA NA no no no no no no Salmonella infection Amoebiasis 0 0 0.506821107 kegg kegg NA NA no no no no no no Selenocompound metabolism Amoebiasis 0 0 -0.628056628 kegg kegg NA NA no no no no no no Serotonergic synapse Amoebiasis 0 0.494071146 0.773487773 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Amoebiasis -0.592173913 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Amoebiasis 0 -0.636363636 -0.729472329 kegg kegg NA NA no no no no no no Spliceosome Amoebiasis -0.413043478 0 -0.567052767 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Amoebiasis 0 0.64229249 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Amoebiasis 0 -0.537549407 -0.439124839 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Amoebiasis 0 -0.544466403 -0.474903475 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Amoebiasis 0 0.605731225 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Amoebiasis -0.552173913 -0.699604743 -0.487001287 kegg kegg NA NA no no no no no no Taste transduction Amoebiasis -0.509565217 -0.596837945 -0.691119691 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Amoebiasis 0 0 -0.408751609 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Amoebiasis -0.426956522 -0.45256917 -0.698584299 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Amoebiasis 0 -0.681818182 -0.465637066 kegg kegg NA NA no no no no no no Thermogenesis Amoebiasis 0 -0.609683794 0 kegg kegg NA NA no no no no no no Thiamine metabolism Amoebiasis -0.595652174 -0.73715415 0 kegg kegg NA NA no no no no no no TNF signaling pathway Amoebiasis 0 0.597826087 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Amoebiasis 0.446956522 0.755928854 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Amoebiasis -0.424347826 -0.62944664 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Amoebiasis 0 0.514822134 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Amoebiasis 0 -0.672924901 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Amoebiasis -0.640869565 -0.644268775 -0.587644788 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Amoebiasis 0 -0.416996047 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Amoebiasis -0.579130435 -0.795454545 -0.467438867 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Amoebiasis 0 -0.747035573 -0.421879022 kegg kegg NA NA no no no no no no VEGF signaling pathway Amoebiasis 0 0.551383399 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Amoebiasis 0 0 0.403346203 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Amoebiasis 0.587826087 0.503952569 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Amoebiasis 0 -0.794466403 -0.66023166 kegg kegg NA NA no no no no no no Yersinia infection Amoebiasis 0 0.528656126 0 kegg kegg NA NA no no no no no no ABC transporters Amphetamine addiction -0.477391304 0 0 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes Amphetamine addiction 0.73826087 0.767786561 0.857657658 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Amphetamine addiction 0 -0.752964427 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Amphetamine addiction -0.577391304 -0.662055336 -0.454054054 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Amphetamine addiction 0.854782609 0.87944664 0.935907336 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Amphetamine addiction 0 -0.432806324 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Amphetamine addiction -0.680869565 -0.538537549 -0.683397683 kegg kegg NA NA no no no no no no Alzheimer disease Amphetamine addiction 0.555652174 0.757905138 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Amphetamine addiction -0.414782609 0 -0.547232947 kegg kegg NA NA no no no no no no AMPK signaling pathway Amphetamine addiction 0 0.614624506 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Amphetamine addiction 0.613913043 0.806324111 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Amphetamine addiction -0.444347826 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Amphetamine addiction 0 0.624505929 0 kegg kegg NA NA no no no no no no Apoptosis Amphetamine addiction -0.58 -0.787549407 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Amphetamine addiction -0.549565217 -0.73715415 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Amphetamine addiction -0.614782609 -0.685770751 -0.422136422 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Amphetamine addiction 0 0 -0.527413127 kegg kegg NA NA no no no no no no Autophagy - animal Amphetamine addiction 0 -0.579051383 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Amphetamine addiction 0 -0.754940711 0 kegg kegg NA NA no no no no no no Basal transcription factors Amphetamine addiction 0 0.635375494 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Amphetamine addiction -0.493913043 0 0 kegg kegg NA NA no no no no no no Bile secretion Amphetamine addiction 0.710434783 0.546442688 0.56962677 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Amphetamine addiction -0.717391304 -0.820158103 -0.489060489 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Amphetamine addiction 0 0.688735178 0 kegg kegg NA NA no no no no no no Butanoate metabolism Amphetamine addiction 0 0.458498024 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Amphetamine addiction 0 -0.779644269 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Amphetamine addiction 0.627826087 0.543478261 0.748262548 kegg kegg NA NA no up up no no no cAMP signaling pathway Amphetamine addiction 0.569565217 0 0.570656371 yes kegg kegg NA NA no up up no no no Carbon metabolism Amphetamine addiction -0.549565217 0 -0.57992278 kegg kegg NA NA no no no no no no Cardiac muscle contraction Amphetamine addiction 0.526956522 0.696640316 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Amphetamine addiction -0.520869565 -0.78458498 0 kegg kegg NA NA no no no no no no Cell cycle Amphetamine addiction 0 0.658102767 0 kegg kegg NA NA no no no no no no Cellular senescence Amphetamine addiction -0.466956522 -0.750988142 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Amphetamine addiction 0 -0.778656126 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Amphetamine addiction 0 -0.729249012 0 kegg kegg NA NA no no no no no no Cholesterol metabolism Amphetamine addiction 0 -0.555335968 -0.475160875 yes kegg kegg NA NA no no up no no no Circadian entrainment Amphetamine addiction 0.750434783 0.67687747 0.765765766 kegg kegg NA NA no up up no no no Circadian rhythm Amphetamine addiction 0.431304348 0.581027668 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Amphetamine addiction 0 0.456521739 0 kegg kegg NA NA no no no no no no Cocaine addiction Amphetamine addiction 0.70173913 0.583992095 0.79021879 kegg kegg NA NA no no no no no no Complement and coagulation cascades Amphetamine addiction -0.7 -0.781620553 0 kegg kegg NA NA no no no no no no Coprococcus Amphetamine addiction 0 0 -0.476993373 butyrate-producing Genus kegg 0.612 NA no no no no no no Cortisol synthesis and secretion Amphetamine addiction 0.745217391 0.645256917 0.804890605 kegg kegg NA NA no no up no no no Cushing syndrome Amphetamine addiction 0.776521739 0.73715415 0.754440154 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Amphetamine addiction 0 0.486166008 0 kegg kegg NA NA no no no no no no DNA replication Amphetamine addiction 0 0.619565217 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Amphetamine addiction 0.831304348 0.765810277 0.923037323 kegg kegg NA NA no up no no no no Dorea Amphetamine addiction -0.450434783 0 0 Genus kegg 0.00362 NA up no dn no no no Drug metabolism - cytochrome P450 Amphetamine addiction 0 0.568181818 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Amphetamine addiction -0.482608696 0.475296443 -0.482882883 kegg kegg NA NA no no no no no no ECM-receptor interaction Amphetamine addiction 0 0 0.487516088 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Amphetamine addiction 0 0.531620553 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Amphetamine addiction 0.782608696 0.786561265 0.813899614 kegg kegg NA NA no no no no no no Endocrine resistance Amphetamine addiction 0.802608696 0.537549407 0.687516088 kegg kegg NA NA no no no no no no Endocytosis Amphetamine addiction -0.544347826 -0.782608696 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Amphetamine addiction 0.459130435 0.709486166 0.474131274 kegg kegg NA NA no no no no no no Ether lipid metabolism Amphetamine addiction 0.510434783 0.738142292 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Amphetamine addiction 0 0.448616601 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Amphetamine addiction -0.57826087 -0.645256917 -0.671557272 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Amphetamine addiction -0.546956522 -0.709486166 -0.505534106 kegg kegg NA NA no no no no no no Fatty acid degradation Amphetamine addiction -0.630434783 -0.579051383 -0.719433719 kegg kegg NA NA no no no no no no Fatty acid metabolism Amphetamine addiction -0.643478261 -0.598814229 -0.601544402 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Amphetamine addiction 0 -0.791501976 -0.455083655 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Amphetamine addiction -0.622608696 -0.790513834 -0.417503218 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Amphetamine addiction -0.573043478 0 -0.653281853 kegg kegg NA NA no no no no no no GABAergic synapse Amphetamine addiction -0.43826087 -0.540513834 0 kegg kegg NA NA no up up no no no Galactose metabolism Amphetamine addiction -0.6 -0.624505929 -0.543114543 kegg kegg NA NA no no no no no no Gap junction Amphetamine addiction 0.58 0 0.503732304 kegg kegg NA NA no no no no no no Gastric acid secretion Amphetamine addiction 0 0.56916996 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Amphetamine addiction 0.842608696 0.940711462 0.764221364 kegg kegg NA NA no no no no no no Glutamatergic synapse Amphetamine addiction 0.44173913 0 0.415958816 kegg kegg NA NA no up up no no no Glutathione metabolism Amphetamine addiction 0 0.706521739 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Amphetamine addiction -0.472173913 0 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Amphetamine addiction 0 0.601778656 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Amphetamine addiction -0.415652174 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Amphetamine addiction -0.544347826 -0.574110672 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Amphetamine addiction 0.472173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Amphetamine addiction -0.405217391 -0.527667984 -0.452252252 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Amphetamine addiction 0 0.498023715 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Amphetamine addiction -0.702608696 -0.718379447 -0.526383526 kegg kegg NA NA no no no no no no GnRH signaling pathway Amphetamine addiction 0.807826087 0.683794466 0.949292149 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Amphetamine addiction 0.482608696 0 0.553925354 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Amphetamine addiction 0.475652174 0.433794466 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Amphetamine addiction 0 0.445652174 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Amphetamine addiction 0 -0.56027668 -0.424710425 kegg kegg NA NA no no no no no no Histidine metabolism Amphetamine addiction 0 0 -0.655341055 kegg kegg NA NA no no no no no no Huntington disease Amphetamine addiction 0.556521739 0.774703557 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Amphetamine addiction -0.480869565 -0.726284585 -0.429086229 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Amphetamine addiction 0.807826087 0.863636364 0.875933076 kegg kegg NA NA no no no no no no Insulin resistance Amphetamine addiction 0 -0.517786561 0 kegg kegg NA NA no no no no no no Insulin secretion Amphetamine addiction 0.747826087 0.677865613 0.832175032 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Amphetamine addiction 0 0.571146245 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Amphetamine addiction 0 -0.4743083 0 kegg kegg NA NA no no no no no no Long-term depression Amphetamine addiction 0.66 0 0.716602317 kegg kegg NA NA no no no no no no Long-term potentiation Amphetamine addiction 0.466086957 0 0 kegg kegg NA NA no no up no no no Lysosome Amphetamine addiction -0.49826087 -0.697628458 -0.574259974 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Amphetamine addiction 0 0.514822134 0 kegg kegg NA NA no up no no no no Melanogenesis Amphetamine addiction 0.813913043 0.843873518 0.900900901 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Amphetamine addiction 0 0.491106719 0 kegg kegg NA NA no no no no no no Mineral absorption Amphetamine addiction 0.565217391 0.421936759 0 kegg kegg NA NA no no no no no no Mismatch repair Amphetamine addiction 0 0.523715415 0 kegg kegg NA NA no no no no no no Mitophagy - animal Amphetamine addiction 0.593913043 0.668972332 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Amphetamine addiction 0.570434783 0.732213439 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Amphetamine addiction 0 0.536561265 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Amphetamine addiction 0.420869565 0.665019763 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Amphetamine addiction -0.52173913 -0.745059289 0 kegg kegg NA NA no no no no no no Necroptosis Amphetamine addiction 0.535652174 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Amphetamine addiction -0.41826087 -0.730237154 -0.510682111 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Amphetamine addiction 0 -0.644268775 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Amphetamine addiction -0.679130435 -0.742094862 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Amphetamine addiction -0.523478261 -0.654150198 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Amphetamine addiction -0.680869565 -0.697628458 -0.556499356 kegg kegg NA NA no no no no no no Nitrogen metabolism Amphetamine addiction -0.557391304 -0.616600791 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Amphetamine addiction -0.726086957 -0.785573123 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Amphetamine addiction 0.585217391 0.729249012 0.414671815 kegg kegg NA NA no no no no no no Nucleotide excision repair Amphetamine addiction 0 0.630434783 0 kegg kegg NA NA no no no no no no Olfactory transduction Amphetamine addiction 0 -0.643280632 -0.53024453 kegg kegg NA NA no no no no no no One carbon pool by folate Amphetamine addiction 0 0.670948617 0 kegg kegg NA NA no no no no no no Oocyte meiosis Amphetamine addiction 0.467826087 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Amphetamine addiction -0.71826087 -0.851778656 0 kegg kegg NA NA no no no no no no Other glycan degradation Amphetamine addiction -0.548695652 0 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Amphetamine addiction 0.724347826 0.533596838 0.572458172 kegg kegg NA NA no up up no no no Oxidative phosphorylation Amphetamine addiction 0.54 0.73715415 0 kegg kegg NA NA no no no no no no Pancreatic secretion Amphetamine addiction 0.740869565 0.68972332 0.843500644 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Amphetamine addiction -0.533913043 -0.675889328 -0.712483912 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Amphetamine addiction 0.695652174 0.730237154 0.722522523 kegg kegg NA NA no no no no no no Parkinson disease Amphetamine addiction 0.677391304 0.745059289 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Amphetamine addiction 0.677391304 0.770750988 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Amphetamine addiction 0 0.596837945 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Amphetamine addiction -0.670434783 -0.78458498 -0.558043758 kegg kegg NA NA no no no no no no Peroxisome Amphetamine addiction -0.68173913 -0.66798419 -0.504504505 kegg kegg NA NA no no no no no no Phagosome Amphetamine addiction -0.557391304 -0.796442688 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Amphetamine addiction 0.503478261 0.414031621 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Amphetamine addiction 0 -0.444664032 0 kegg kegg NA NA no up up no no no Phototransduction Amphetamine addiction 0.451304348 0 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Amphetamine addiction 0 0.58201581 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Amphetamine addiction -0.493913043 -0.807312253 0 kegg kegg NA NA no no no no no no Prevotella Amphetamine addiction 0 0 0.409397432 acetate-producing Genus kegg 0.287 NA no no no no no no Prion disease Amphetamine addiction 0.548695652 0.714426877 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Amphetamine addiction 0 -0.662055336 0 kegg kegg NA NA no no no no no no Propanoate metabolism Amphetamine addiction 0 0.441699605 0 kegg kegg NA NA no no no no no no Proteasome Amphetamine addiction 0 0 -0.422908623 kegg kegg NA NA no no no no no no Protein digestion and absorption Amphetamine addiction -0.556521739 -0.643280632 -0.461003861 yes kegg kegg NA NA no up up no no no Protein export Amphetamine addiction 0.566956522 0.612648221 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Amphetamine addiction 0.568695652 0.726284585 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Amphetamine addiction 0 0.603754941 0 kegg kegg NA NA no no no no no no Purine metabolism Amphetamine addiction 0 0.633399209 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Amphetamine addiction -0.443478261 0.583992095 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Amphetamine addiction 0 0.60770751 0 kegg kegg NA NA no no no no no no Ras signaling pathway Amphetamine addiction 0 0.490118577 0 yes kegg kegg NA NA no up up no no no Regulation of lipolysis in adipocytes Amphetamine addiction 0.70173913 0.483201581 0.712741313 kegg kegg NA NA no no no no no no Relaxin signaling pathway Amphetamine addiction 0 0 0.522779923 kegg kegg NA NA no no no no no no Renin secretion Amphetamine addiction 0.717391304 0.84486166 0.764221364 kegg kegg NA NA no no no no no no Renin-angiotensin system Amphetamine addiction -0.519130435 -0.791501976 -0.536422136 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Amphetamine addiction 0 0.671936759 0 kegg kegg NA NA no no up no no no Ribosome Amphetamine addiction 0.584347826 0.650197628 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Amphetamine addiction 0 0.636363636 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Amphetamine addiction 0 -0.674901186 0 kegg kegg NA NA no no no no no no RNA degradation Amphetamine addiction 0.517391304 0.705533597 0 kegg kegg NA NA no no no no no no RNA polymerase Amphetamine addiction 0 0.774703557 0 kegg kegg NA NA no no no no no no Ruminococcus Amphetamine addiction 0.551304348 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Salivary secretion Amphetamine addiction 0 0 0.516087516 kegg kegg NA NA no no no no no no Sarcina Amphetamine addiction 0 -0.422326513 0 Genus kegg 0.0703 NA no no no no no no Serotonergic synapse Amphetamine addiction 0.548695652 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Amphetamine addiction 0 -0.476284585 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Amphetamine addiction 0 0 -0.473616474 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Amphetamine addiction 0 -0.639328063 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Amphetamine addiction 0 0.446640316 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Amphetamine addiction -0.674782609 -0.662055336 -0.688545689 kegg kegg NA NA no no no no no no Steroid biosynthesis Amphetamine addiction 0.628695652 0.499011858 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Amphetamine addiction 0 0.453557312 -0.412612613 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Amphetamine addiction 0 -0.678853755 -0.672329472 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Amphetamine addiction 0 0.541501976 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Amphetamine addiction 0 -0.531620553 0 kegg kegg NA NA no no no no no no Taste transduction Amphetamine addiction 0 0.603754941 0 kegg kegg NA NA no no up no no no TGF-beta signaling pathway Amphetamine addiction 0.463478261 0.552371542 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Amphetamine addiction 0 -0.531620553 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Amphetamine addiction 0 -0.545454545 0 kegg kegg NA NA no no no no no no Thermogenesis Amphetamine addiction 0.630434783 0.758893281 0 kegg kegg NA NA no no no no no no Thiamine metabolism Amphetamine addiction 0 0.493083004 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Amphetamine addiction 0 0.429841897 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Amphetamine addiction 0.671304348 0.654150198 0.626254826 kegg kegg NA NA no no no no no no TNF signaling pathway Amphetamine addiction 0 -0.653162055 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Amphetamine addiction 0 -0.801383399 0 yes kegg kegg NA NA no no no no no no Type I diabetes mellitus Amphetamine addiction -0.426086957 -0.688735178 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Amphetamine addiction 0 -0.414031621 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Amphetamine addiction 0 0.579051383 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Amphetamine addiction 0 0.421936759 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Amphetamine addiction 0.677391304 0.774703557 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Amphetamine addiction 0 0.5 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Amphetamine addiction 0 0.445652174 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Amphetamine addiction 0.708695652 0.685770751 0.754697555 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Amphetamine addiction 0.862608696 0.76284585 0.783783784 kegg kegg NA NA no no no no no no VEGF signaling pathway Amphetamine addiction 0 -0.583003953 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Amphetamine addiction 0.504347826 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Amphetamine addiction 0.535652174 0.712450593 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism AMPK signaling pathway 0 0 -0.475933076 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism AMPK signaling pathway 0 -0.460474308 -0.526640927 kegg kegg NA NA no no no no no no Arginine and proline metabolism AMPK signaling pathway -0.471304348 0 0 kegg kegg NA NA no up no no no no Ascorbate and aldarate metabolism AMPK signaling pathway 0 0 -0.411583012 kegg kegg NA NA no no no no no no Basal transcription factors AMPK signaling pathway 0 0.462450593 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids AMPK signaling pathway 0 -0.470355731 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors AMPK signaling pathway 0.54 0.66798419 0.712483912 kegg kegg NA NA no no no no no no Calcium signaling pathway AMPK signaling pathway 0 0.438735178 0 kegg kegg NA NA no up up no no no Carbon metabolism AMPK signaling pathway 0 -0.498023715 0 kegg kegg NA NA no no no no no no Cell cycle AMPK signaling pathway 0 0.509881423 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway AMPK signaling pathway -0.554782609 -0.57312253 -0.522522523 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) AMPK signaling pathway 0 0 -0.435778636 kegg kegg NA NA no no no no no no Clostridium AMPK signaling pathway -0.445456364 -0.424841882 0 Genus kegg 0.925 NA no no no no no no Cytokine-cytokine receptor interaction AMPK signaling pathway 0 -0.420948617 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 AMPK signaling pathway 0 0 -0.410553411 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes AMPK signaling pathway 0 0 -0.552380952 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance AMPK signaling pathway 0 0.424901186 0 kegg kegg NA NA no no no no no no Eggerthella AMPK signaling pathway 0 0.467400551 0 Genus kegg 0.912 NA no no no no no no Endocrine resistance AMPK signaling pathway 0 0.579051383 0.484684685 kegg kegg NA NA no no no no no no Endocytosis AMPK signaling pathway 0 -0.648221344 0 kegg kegg NA NA no no no no no no Ether lipid metabolism AMPK signaling pathway 0 0.494071146 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis AMPK signaling pathway -0.453043478 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism AMPK signaling pathway -0.410434783 0 0 kegg kegg NA NA no no no no no no Galactose metabolism AMPK signaling pathway 0 -0.517786561 0 kegg kegg NA NA no no no no no no Glutathione metabolism AMPK signaling pathway 0.61826087 0.605731225 0.644787645 kegg kegg NA NA no no no no no no Glycerolipid metabolism AMPK signaling pathway 0 0 -0.558558559 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism AMPK signaling pathway 0 0 -0.43989704 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" AMPK signaling pathway 0.633043478 0.725296443 0.759330759 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate AMPK signaling pathway 0 0 -0.515057915 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin AMPK signaling pathway 0 0 -0.592020592 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation AMPK signaling pathway 0 -0.688735178 -0.747232947 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis AMPK signaling pathway 0 0.59486166 0 kegg kegg NA NA no no no no no no Histidine metabolism AMPK signaling pathway 0 -0.500988142 0 kegg kegg NA NA no no no no no no Lysosome AMPK signaling pathway 0 -0.696640316 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis AMPK signaling pathway 0 0 -0.408236808 kegg kegg NA NA no no no no no no Mitophagy - animal AMPK signaling pathway 0.545217391 0.650197628 0.711711712 kegg kegg NA NA no no no no no no mRNA surveillance pathway AMPK signaling pathway 0 0.54743083 0 kegg kegg NA NA no no no no no no mTOR signaling pathway AMPK signaling pathway 0 0.462450593 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction AMPK signaling pathway -0.525217391 -0.645256917 0 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway AMPK signaling pathway -0.413043478 0 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism AMPK signaling pathway -0.42 -0.437747036 0 kegg kegg NA NA no no no no no no Other glycan degradation AMPK signaling pathway 0 0 -0.64967825 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis AMPK signaling pathway 0 0.480237154 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis AMPK signaling pathway -0.62173913 -0.608695652 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions AMPK signaling pathway 0 0 -0.472329472 kegg kegg NA NA no no no no no no Pentose phosphate pathway AMPK signaling pathway 0 -0.658102767 0 kegg kegg NA NA no no no no no no Peroxisome AMPK signaling pathway -0.424347826 -0.428853755 0 kegg kegg NA NA no no no no no no Phagosome AMPK signaling pathway 0 -0.727272727 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism AMPK signaling pathway 0.684347826 0.705533597 0.761904762 kegg kegg NA NA no no no no no no PPAR signaling pathway AMPK signaling pathway -0.529565217 0 0 kegg kegg NA NA no no no no no no Proteasome AMPK signaling pathway 0 0 -0.425482625 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum AMPK signaling pathway 0.502608696 0.54743083 0.545173745 kegg kegg NA NA no no no no no no Purine metabolism AMPK signaling pathway 0.836521739 0.768774704 0.678507079 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes AMPK signaling pathway 0 0.427865613 0 kegg kegg NA NA no no no no no no RNA polymerase AMPK signaling pathway 0 0.479249012 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport AMPK signaling pathway 0 0 -0.554440154 kegg kegg NA NA no no no no no no Sphingolipid metabolism AMPK signaling pathway 0 -0.431818182 -0.501673102 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway AMPK signaling pathway 0 0 -0.511454311 kegg kegg NA NA no no no no no no Starch and sucrose metabolism AMPK signaling pathway -0.411304348 -0.53458498 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis AMPK signaling pathway 0 0 -0.41029601 kegg kegg NA NA no no no no no no Sulfur metabolism AMPK signaling pathway 0.489565217 0 0.577863578 kegg kegg NA NA no no no no no no Thiamine metabolism AMPK signaling pathway 0 0.447628458 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis AMPK signaling pathway 0.584347826 0.672924901 0.706048906 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Amyotrophic lateral sclerosis -0.480869565 0.46541502 0 kegg kegg NA NA no no no no no no ABC transporters Amyotrophic lateral sclerosis -0.410434783 0 0 kegg kegg NA NA no up up no no no Adherens junction Amyotrophic lateral sclerosis 0 0.661067194 0.629343629 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Amyotrophic lateral sclerosis 0.730434783 0.838932806 0.423166023 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Amyotrophic lateral sclerosis 0 -0.876482213 -0.488803089 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Amyotrophic lateral sclerosis -0.616521739 -0.837944664 -0.576833977 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Amyotrophic lateral sclerosis 0.626086957 0.792490119 0.408751609 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Amyotrophic lateral sclerosis -0.629565217 -0.738142292 0 kegg kegg NA NA no no no no no no Alzheimer disease Amyotrophic lateral sclerosis 0.967826087 0.975296443 0.937709138 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Amyotrophic lateral sclerosis -0.593913043 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Amyotrophic lateral sclerosis -0.573913043 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Amyotrophic lateral sclerosis 0 0.462450593 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Amyotrophic lateral sclerosis 0 0.722332016 0 kegg kegg NA NA no no no no no no Apoptosis Amyotrophic lateral sclerosis -0.44173913 -0.630434783 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Amyotrophic lateral sclerosis -0.450434783 -0.851778656 -0.652252252 kegg kegg NA NA no up no no no no Arginine biosynthesis Amyotrophic lateral sclerosis -0.639130435 -0.803359684 -0.533590734 kegg kegg NA NA no no no no no no Autophagy - animal Amyotrophic lateral sclerosis 0 -0.747035573 -0.514800515 kegg kegg NA NA no no no no no no Axon guidance Amyotrophic lateral sclerosis 0.497391304 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Amyotrophic lateral sclerosis 0 -0.673913043 0 kegg kegg NA NA no no no no no no Bacteroides Amyotrophic lateral sclerosis -0.409565217 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no beta-Alanine metabolism Amyotrophic lateral sclerosis -0.69826087 0 0 kegg kegg NA NA no no no no no no Bile secretion Amyotrophic lateral sclerosis 0.482608696 0.463438735 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Amyotrophic lateral sclerosis -0.807826087 -0.731225296 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Amyotrophic lateral sclerosis 0 0.450592885 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Amyotrophic lateral sclerosis -0.43826087 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Amyotrophic lateral sclerosis -0.539130435 0.434782609 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Amyotrophic lateral sclerosis 0 -0.683794466 -0.479279279 kegg kegg NA NA no no no no no no Calcium signaling pathway Amyotrophic lateral sclerosis 0.723478261 0.72826087 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Amyotrophic lateral sclerosis 0.762608696 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Amyotrophic lateral sclerosis 0 -0.470355731 0 kegg kegg NA NA no no no no no no Carbon metabolism Amyotrophic lateral sclerosis -0.723478261 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Amyotrophic lateral sclerosis 0.963478261 0.956521739 0.944401544 kegg kegg NA NA no no up no no no Cell adhesion molecules Amyotrophic lateral sclerosis -0.544347826 -0.471343874 0 kegg kegg NA NA no no no no no no Cell cycle Amyotrophic lateral sclerosis 0 0.494071146 0 kegg kegg NA NA no no no no no no Cellular senescence Amyotrophic lateral sclerosis 0 -0.467391304 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Amyotrophic lateral sclerosis 0 -0.748023715 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Amyotrophic lateral sclerosis 0 -0.578063241 0 kegg kegg NA NA no no no no no no Cholinergic synapse Amyotrophic lateral sclerosis 0 -0.483201581 0 kegg kegg NA NA no no no no no no Circadian entrainment Amyotrophic lateral sclerosis 0 0.568181818 0 kegg kegg NA NA no up up no no no Circadian rhythm Amyotrophic lateral sclerosis 0.630434783 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Amyotrophic lateral sclerosis 0 0.490118577 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Amyotrophic lateral sclerosis -0.622608696 -0.739130435 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Amyotrophic lateral sclerosis 0.444347826 0.425889328 0 kegg kegg NA NA no no up no no no Cushing syndrome Amyotrophic lateral sclerosis 0.526086957 0.510869565 0 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Amyotrophic lateral sclerosis 0 0.479249012 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Amyotrophic lateral sclerosis 0 -0.504940711 0 kegg kegg NA NA no no no no no no DNA replication Amyotrophic lateral sclerosis 0 0.543478261 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Amyotrophic lateral sclerosis 0.656521739 0.707509881 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Amyotrophic lateral sclerosis 0 0.583992095 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Amyotrophic lateral sclerosis -0.583478261 0.62055336 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Amyotrophic lateral sclerosis 0 0.636363636 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Amyotrophic lateral sclerosis 0.566956522 0.801383399 0 kegg kegg NA NA no no no no no no Endocrine resistance Amyotrophic lateral sclerosis 0.451304348 0 0 kegg kegg NA NA no no no no no no Endocytosis Amyotrophic lateral sclerosis -0.49826087 -0.509881423 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Amyotrophic lateral sclerosis 0 -0.431818182 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Amyotrophic lateral sclerosis 0 0.463438735 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Amyotrophic lateral sclerosis 0.755652174 0.571146245 0.426512227 kegg kegg NA NA no no no no no no Fat digestion and absorption Amyotrophic lateral sclerosis -0.605217391 -0.693675889 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Amyotrophic lateral sclerosis -0.548695652 -0.878458498 -0.672329472 kegg kegg NA NA no no no no no no Fatty acid degradation Amyotrophic lateral sclerosis -0.730434783 -0.845849802 0 kegg kegg NA NA no no no no no no Fatty acid elongation Amyotrophic lateral sclerosis -0.503478261 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Amyotrophic lateral sclerosis -0.819130435 -0.847826087 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Amyotrophic lateral sclerosis 0 -0.757905138 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Amyotrophic lateral sclerosis -0.54 -0.721343874 -0.473101673 kegg kegg NA NA no no no no no no Focal adhesion Amyotrophic lateral sclerosis 0 0.528656126 0.518918919 kegg kegg NA NA no up up no no no Folate biosynthesis Amyotrophic lateral sclerosis 0 0.542490119 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Amyotrophic lateral sclerosis 0 -0.734189723 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Amyotrophic lateral sclerosis -0.716521739 -0.496047431 -0.456885457 kegg kegg NA NA no no no no no no GABAergic synapse Amyotrophic lateral sclerosis -0.462608696 -0.7243083 -0.433462033 kegg kegg NA NA no up up no no no Galactose metabolism Amyotrophic lateral sclerosis -0.732173913 -0.755928854 0 kegg kegg NA NA no no no no no no Gastric acid secretion Amyotrophic lateral sclerosis 0 0.739130435 0.614414414 kegg kegg NA NA no no no no no no Glucagon signaling pathway Amyotrophic lateral sclerosis 0.454782609 0.81027668 0 kegg kegg NA NA no no no no no no Glutathione metabolism Amyotrophic lateral sclerosis 0 0.673913043 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Amyotrophic lateral sclerosis 0 -0.528656126 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Amyotrophic lateral sclerosis 0 0.425889328 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Amyotrophic lateral sclerosis -0.615652174 0.41798419 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Amyotrophic lateral sclerosis -0.42173913 -0.732213439 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Amyotrophic lateral sclerosis 0.580869565 0.443675889 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Amyotrophic lateral sclerosis -0.739130435 -0.817193676 -0.603603604 kegg kegg NA NA no no no no no no GnRH signaling pathway Amyotrophic lateral sclerosis 0.41826087 0.489130435 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Amyotrophic lateral sclerosis 0.489565217 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Amyotrophic lateral sclerosis 0 0.592885375 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Amyotrophic lateral sclerosis 0 0.686758893 0.650965251 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Amyotrophic lateral sclerosis 0 -0.743083004 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Amyotrophic lateral sclerosis 0 -0.650197628 -0.546203346 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Amyotrophic lateral sclerosis 0.553043478 0.827075099 0 kegg kegg NA NA no no no no no no Insulin resistance Amyotrophic lateral sclerosis 0 -0.552371542 0 kegg kegg NA NA no no no no no no Insulin secretion Amyotrophic lateral sclerosis 0.42173913 0.553359684 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Amyotrophic lateral sclerosis 0 0.658102767 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Amyotrophic lateral sclerosis 0 -0.719367589 0 kegg kegg NA NA no no no no no no Long-term depression Amyotrophic lateral sclerosis 0.58173913 0 0 kegg kegg NA NA no no no no no no Lysosome Amyotrophic lateral sclerosis 0 -0.476284585 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Amyotrophic lateral sclerosis 0.52173913 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Amyotrophic lateral sclerosis 0 -0.628458498 0 kegg kegg NA NA no no no no no no Melanogenesis Amyotrophic lateral sclerosis 0.572173913 0.860671937 0.404890605 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Amyotrophic lateral sclerosis 0 0.533596838 0 kegg kegg NA NA no no no no no no Mineral absorption Amyotrophic lateral sclerosis 0.446086957 0.557312253 0 kegg kegg NA NA no no no no no no Mitophagy - animal Amyotrophic lateral sclerosis 0.593043478 0.778656126 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Amyotrophic lateral sclerosis 0.73826087 0.734189723 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Amyotrophic lateral sclerosis 0 0.62944664 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Amyotrophic lateral sclerosis 0 0.674901186 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Amyotrophic lateral sclerosis -0.470434783 -0.467391304 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Amyotrophic lateral sclerosis 0 -0.567193676 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Amyotrophic lateral sclerosis 0.525217391 -0.424901186 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Amyotrophic lateral sclerosis -0.534782609 -0.612648221 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Amyotrophic lateral sclerosis 0 -0.727272727 -0.51969112 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Amyotrophic lateral sclerosis -0.546086957 -0.822134387 -0.58018018 kegg kegg NA NA no no no no no no Nitrogen metabolism Amyotrophic lateral sclerosis -0.524347826 -0.7243083 -0.492921493 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Amyotrophic lateral sclerosis -0.433913043 -0.81027668 -0.503217503 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Amyotrophic lateral sclerosis 0.963478261 0.934782609 0.902702703 kegg kegg NA NA no no no no no no Non-homologous end-joining Amyotrophic lateral sclerosis -0.616521739 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Amyotrophic lateral sclerosis 0 0.425889328 0 kegg kegg NA NA no no no no no no Olfactory transduction Amyotrophic lateral sclerosis 0 -0.686758893 0 kegg kegg NA NA no no no no no no One carbon pool by folate Amyotrophic lateral sclerosis 0 0.43083004 0 kegg kegg NA NA no no no no no no Oocyte meiosis Amyotrophic lateral sclerosis 0.409565217 0.461462451 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Amyotrophic lateral sclerosis 0 -0.807312253 -0.514028314 kegg kegg NA NA no no no no no no Oxidative phosphorylation Amyotrophic lateral sclerosis 0.973913043 0.970355731 0.950836551 kegg kegg NA NA no no no no no no Pancreatic secretion Amyotrophic lateral sclerosis 0.704347826 0.736166008 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Amyotrophic lateral sclerosis -0.427826087 -0.842885375 -0.522522523 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Amyotrophic lateral sclerosis 0.731304348 0.744071146 0 kegg kegg NA NA no no no no no no Parkinson disease Amyotrophic lateral sclerosis 0.879130435 0.935770751 0.450707851 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Amyotrophic lateral sclerosis 0 0.630434783 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Amyotrophic lateral sclerosis -0.506086957 -0.650197628 -0.471814672 kegg kegg NA NA no no no no no no Peroxisome Amyotrophic lateral sclerosis -0.684347826 -0.779644269 -0.42960103 kegg kegg NA NA no no no no no no Phagosome Amyotrophic lateral sclerosis -0.590434783 -0.516798419 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Amyotrophic lateral sclerosis 0.533043478 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Amyotrophic lateral sclerosis 0 -0.544466403 0 kegg kegg NA NA no up up no no no Phototransduction Amyotrophic lateral sclerosis 0 0.496047431 0.474646075 kegg kegg NA NA no no no no no no Platelet activation Amyotrophic lateral sclerosis 0 0.530632411 0.441441441 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Amyotrophic lateral sclerosis 0 0.443675889 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Amyotrophic lateral sclerosis 0 -0.678853755 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Amyotrophic lateral sclerosis 0 -0.685770751 -0.491119691 kegg kegg NA NA no no no no no no Propanoate metabolism Amyotrophic lateral sclerosis 0 0.434782609 0 kegg kegg NA NA no no no no no no Proteasome Amyotrophic lateral sclerosis 0 0.532608696 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Amyotrophic lateral sclerosis -0.732173913 -0.811264822 -0.471042471 yes kegg kegg NA NA no up up no no no Protein export Amyotrophic lateral sclerosis 0.556521739 0.805335968 0.424967825 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Amyotrophic lateral sclerosis 0 0.718379447 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Amyotrophic lateral sclerosis 0 0.562252964 0 kegg kegg NA NA no no no no no no Purine metabolism Amyotrophic lateral sclerosis 0 0.495059289 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Amyotrophic lateral sclerosis -0.755652174 0.456521739 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Amyotrophic lateral sclerosis 0 0.585968379 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Amyotrophic lateral sclerosis 0 0.41798419 0.425740026 kegg kegg NA NA no no no no no no Ras signaling pathway Amyotrophic lateral sclerosis 0 0.576086957 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Amyotrophic lateral sclerosis 0 0 0.437580438 kegg kegg NA NA no no no no no no Relaxin signaling pathway Amyotrophic lateral sclerosis 0.571304348 0 0 kegg kegg NA NA no no no no no no Renin secretion Amyotrophic lateral sclerosis 0 0.83201581 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Amyotrophic lateral sclerosis 0 -0.674901186 0 kegg kegg NA NA no no no no no no Retinol metabolism Amyotrophic lateral sclerosis -0.506086957 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Amyotrophic lateral sclerosis 0.766086957 0.881422925 0.741312741 kegg kegg NA NA no no up no no no Ribosome Amyotrophic lateral sclerosis 0.746086957 0.821146245 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Amyotrophic lateral sclerosis 0 0.437747036 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Amyotrophic lateral sclerosis 0 -0.707509881 -0.503474903 kegg kegg NA NA no no no no no no RNA degradation Amyotrophic lateral sclerosis 0.703478261 0.747035573 0 kegg kegg NA NA no no no no no no RNA polymerase Amyotrophic lateral sclerosis 0 0.637351779 0 kegg kegg NA NA no no no no no no RNA transport Amyotrophic lateral sclerosis 0 0.528656126 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Amyotrophic lateral sclerosis 0.574782609 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Amyotrophic lateral sclerosis 0 -0.590909091 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Amyotrophic lateral sclerosis -0.525217391 -0.846837945 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Amyotrophic lateral sclerosis 0 0 0.41029601 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Amyotrophic lateral sclerosis 0 -0.649209486 0 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Amyotrophic lateral sclerosis 0 -0.490118577 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Amyotrophic lateral sclerosis 0.713043478 0.670948617 0.403088803 kegg kegg NA NA no no no no no no Thermogenesis Amyotrophic lateral sclerosis 0.979130435 0.970355731 0.908108108 kegg kegg NA NA no no no no no no Thiamine metabolism Amyotrophic lateral sclerosis 0 0.440711462 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Amyotrophic lateral sclerosis 0 0.663043478 0.623166023 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Amyotrophic lateral sclerosis 0 0.609683794 0 kegg kegg NA NA no no no no no no Tight junction Amyotrophic lateral sclerosis 0 0.526679842 0 kegg kegg NA NA no no no no no no TNF signaling pathway Amyotrophic lateral sclerosis 0 -0.579051383 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Amyotrophic lateral sclerosis 0 -0.722332016 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Amyotrophic lateral sclerosis -0.527826087 0 0 kegg kegg NA NA no up no no no no Type I diabetes mellitus Amyotrophic lateral sclerosis -0.455652174 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Amyotrophic lateral sclerosis 0 -0.618577075 -0.434491634 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Amyotrophic lateral sclerosis 0.615652174 0.829051383 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Amyotrophic lateral sclerosis -0.426956522 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Amyotrophic lateral sclerosis 0 0.472332016 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Amyotrophic lateral sclerosis 0.740869565 0.849802372 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Amyotrophic lateral sclerosis 0.619130435 0.760869565 0.444787645 kegg kegg NA NA no no no no no no VEGF signaling pathway Amyotrophic lateral sclerosis 0 -0.473320158 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Amyotrophic lateral sclerosis 0.588695652 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Amyotrophic lateral sclerosis 0.76 0.744071146 0.413642214 kegg kegg NA NA no no no no no no Alloscardovia Anaerococcus 0 0 0.436661287 Genus Genus 0.525 0.275 no no no no no no Myroides Anaerococcus 0 0.460720254 0 Genus Genus 0.269 0.275 no no no no no no Eggerthella Anaerotruncus 0.487088644 0 0 Genus Genus 0.912 0.904 no no no no no no 2-Oxocarboxylic acid metabolism Antifolate resistance 0 0.533596838 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Antifolate resistance 0 0.422924901 0.412097812 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Antifolate resistance 0.512173913 0.611660079 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Antifolate resistance 0.513913043 0 0.422908623 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Antifolate resistance 0 -0.464426877 -0.404633205 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Antifolate resistance 0 0.471343874 0 kegg kegg NA NA no no no no no no Butanoate metabolism Antifolate resistance 0.506956522 0.493083004 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Antifolate resistance 0 0.445652174 0 kegg kegg NA NA no no no no no no Endocrine resistance Antifolate resistance 0 0.52173913 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Antifolate resistance 0 0 0.571943372 kegg kegg NA NA no no no no no no Folate biosynthesis Antifolate resistance 0 0 0.42960103 kegg kegg NA NA no no no no no no Glycerolipid metabolism Antifolate resistance 0.503478261 0 0.517117117 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Antifolate resistance 0.477391304 0 0.57966538 kegg kegg NA NA no no up no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Antifolate resistance 0 0.624505929 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Antifolate resistance -0.429565217 -0.530632411 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Antifolate resistance 0 0.568181818 0.453796654 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Antifolate resistance 0.515652174 0.442687747 0 kegg kegg NA NA no no no no no no Histidine metabolism Antifolate resistance 0.466086957 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Antifolate resistance 0.585217391 0.481225296 0.515572716 kegg kegg NA NA no no no no no no Linoleic acid metabolism Antifolate resistance 0 0.540513834 0 kegg kegg NA NA no no no no no no Lysine degradation Antifolate resistance 0 0.549407115 0.542857143 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Antifolate resistance 0 0 0.528442728 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Antifolate resistance 0 0.5256917 0 kegg kegg NA NA no no no no no no One carbon pool by folate Antifolate resistance 0.619130435 0.77173913 0.512741313 kegg kegg NA NA no no no no no no Other glycan degradation Antifolate resistance 0 0 0.406177606 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Antifolate resistance 0.405217391 0.597826087 0.587644788 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Antifolate resistance 0.417391304 0 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Antifolate resistance 0 -0.5 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Antifolate resistance 0.488695652 0.495059289 0 kegg kegg NA NA no no no no no no Propanoate metabolism Antifolate resistance 0.419130435 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Antifolate resistance 0 0.662055336 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Antifolate resistance 0.540869565 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Antifolate resistance 0 0.749011858 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Antifolate resistance 0 0.625494071 0.4998713 kegg kegg NA NA no no no no no no Sphingolipid metabolism Antifolate resistance -0.485217391 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Antifolate resistance 0 0.485177866 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Antifolate resistance 0.468695652 0.570158103 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Antifolate resistance 0 0 0.540797941 kegg kegg NA NA no no no no no no Thiamine metabolism Antifolate resistance 0.447826087 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Antifolate resistance 0.515652174 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Antifolate resistance 0.47826087 0.599802372 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Antifolate resistance 0.58173913 0.605731225 0.497554698 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Antifolate resistance 0.555652174 0.514822134 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Antifolate resistance 0 0.518774704 0 kegg kegg NA NA no no no no no no ABC transporters Antigen processing and presentation 0 -0.56916996 0 kegg kegg NA NA no up up no no no Amino sugar and nucleotide sugar metabolism Antigen processing and presentation 0 -0.436758893 0 kegg kegg NA NA no no no no no no Antifolate resistance Antigen processing and presentation -0.556521739 -0.632411067 -0.499356499 kegg kegg NA NA no no no no no no Apoptosis - multiple species Antigen processing and presentation 0 -0.583992095 0 kegg kegg NA NA no no no no no no Axon guidance Antigen processing and presentation 0 0.509881423 0 kegg kegg NA NA no up up no no no Base excision repair Antigen processing and presentation 0 -0.462450593 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Antigen processing and presentation 0.429565217 0 0.519176319 kegg kegg NA NA no no no no no no Carbon metabolism Antigen processing and presentation 0 0.495059289 0.498326898 kegg kegg NA NA no no no no no no Cell adhesion molecules Antigen processing and presentation 0.509565217 0.538537549 0.705019305 kegg kegg NA NA no no no no no no Cell cycle Antigen processing and presentation 0 -0.429841897 0 kegg kegg NA NA no no no no no no Cellular senescence Antigen processing and presentation 0.619130435 0.420948617 0.496525097 kegg kegg NA NA no no no no no no Clostridium Antigen processing and presentation 0 0.503289904 0 Genus kegg 0.925 NA no no no no no no Complement and coagulation cascades Antigen processing and presentation 0.433913043 0 0.536164736 kegg kegg NA NA no no no no no no Desulfovibrio Antigen processing and presentation 0 0.444554224 0 Genus kegg 0.27 NA no no no no no no Drug metabolism - cytochrome P450 Antigen processing and presentation 0.447826087 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Antigen processing and presentation -0.655652174 -0.719367589 -0.459459459 kegg kegg NA NA no no no no no no Endocytosis Antigen processing and presentation 0.619130435 0.537549407 0.577091377 kegg kegg NA NA no no no no no no ErbB signaling pathway Antigen processing and presentation 0 -0.479249012 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Antigen processing and presentation -0.508695652 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Antigen processing and presentation 0 -0.567193676 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Antigen processing and presentation 0 -0.434782609 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Antigen processing and presentation 0 -0.589920949 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Antigen processing and presentation 0 -0.64229249 -0.461261261 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Antigen processing and presentation -0.733043478 -0.71541502 -0.517631918 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Antigen processing and presentation -0.435652174 -0.603754941 -0.435521236 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Antigen processing and presentation -0.586956522 -0.602766798 -0.523809524 kegg kegg NA NA no no no no no no Homologous recombination Antigen processing and presentation 0 -0.556324111 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Antigen processing and presentation -0.5 -0.618577075 -0.592535393 kegg kegg NA NA no no no no no no Longevity regulating pathway Antigen processing and presentation -0.443478261 0 0 kegg kegg NA NA no no no no no no Lysine degradation Antigen processing and presentation 0 -0.643280632 -0.511454311 kegg kegg NA NA no no no no no no Lysosome Antigen processing and presentation 0 0.541501976 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Antigen processing and presentation 0 -0.510869565 -0.421879022 kegg kegg NA NA no no no no no no MAPK signaling pathway Antigen processing and presentation 0 -0.480237154 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Antigen processing and presentation 0.452173913 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Antigen processing and presentation 0 0 -0.485714286 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Antigen processing and presentation 0.445217391 0.536561265 0.451222651 kegg kegg NA NA up up up no no no Notch signaling pathway Antigen processing and presentation 0 -0.592885375 -0.406692407 kegg kegg NA NA no no no no no no Odoribacter Antigen processing and presentation 0 0.462606669 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Oscillospira Antigen processing and presentation -0.413043478 0 0 LPS-producing Genus kegg 0.62 NA no no no no no no Other types of O-glycan biosynthesis Antigen processing and presentation -0.479130435 -0.703557312 -0.538223938 kegg kegg NA NA no no no no no no p53 signaling pathway Antigen processing and presentation -0.453043478 -0.567193676 -0.409009009 kegg kegg NA NA no no no no no no Phagosome Antigen processing and presentation 0.50173913 0.533596838 0.658172458 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Antigen processing and presentation 0 0 -0.512226512 kegg kegg NA NA no no no no no no Platinum drug resistance Antigen processing and presentation 0 -0.631422925 -0.428571429 kegg kegg NA NA no no no no no no PPAR signaling pathway Antigen processing and presentation 0.52173913 0 0.423938224 kegg kegg NA NA no no no no no no Proteasome Antigen processing and presentation 0 0.496047431 0.47001287 kegg kegg NA NA no no no no no no Purine metabolism Antigen processing and presentation 0 -0.421936759 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Antigen processing and presentation -0.413913043 -0.631422925 -0.41029601 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Antigen processing and presentation -0.416521739 -0.520750988 -0.54954955 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Antigen processing and presentation 0 0.43972332 0 kegg kegg NA NA no no no no no no Spliceosome Antigen processing and presentation 0 -0.509881423 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Antigen processing and presentation -0.526086957 -0.690711462 -0.548262548 kegg kegg NA NA no no no no no no Tight junction Antigen processing and presentation 0 0.479249012 0.414929215 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Antigen processing and presentation 0 0 0.454826255 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Apelin signaling pathway 0 0.447628458 0.41003861 kegg kegg NA NA no no no no no no ABC transporters Apelin signaling pathway 0 -0.477272727 0 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes Apelin signaling pathway 0 0.669960474 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Apelin signaling pathway 0 -0.682806324 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Apelin signaling pathway 0 -0.754940711 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Apelin signaling pathway 0 0.419960474 0 kegg kegg NA NA no no no no no no Apoptosis Apelin signaling pathway -0.57826087 -0.752964427 -0.62007722 kegg kegg NA NA no no no no no no Arginine and proline metabolism Apelin signaling pathway 0 -0.674901186 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Apelin signaling pathway -0.420869565 -0.62944664 -0.438095238 kegg kegg NA NA no no no no no no Autophagy - animal Apelin signaling pathway 0 -0.68972332 0 kegg kegg NA NA no no no no no no Autophagy - other Apelin signaling pathway 0.570434783 0 0 kegg kegg NA NA no no no no no no Bacteroides Apelin signaling pathway 0 0.421936759 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Apelin signaling pathway 0.603478261 0 0.553925354 kegg kegg NA NA no no no no no no Base excision repair Apelin signaling pathway 0.483478261 0 0.567052767 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Apelin signaling pathway -0.411304348 -0.47826087 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Apelin signaling pathway 0 0.48715415 0 kegg kegg NA NA no no no no no no Butanoate metabolism Apelin signaling pathway 0 0.657114625 0.638352638 kegg kegg NA NA no no no no no no Calcium signaling pathway Apelin signaling pathway 0 0.448616601 0 kegg kegg NA NA no up up no no no Cardiac muscle contraction Apelin signaling pathway 0 0.714426877 0 kegg kegg NA NA no no up no no no Cell cycle Apelin signaling pathway 0.592173913 0.482213439 0.419047619 kegg kegg NA NA no no no no no no Cellular senescence Apelin signaling pathway 0 -0.504940711 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Apelin signaling pathway 0 -0.571146245 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Apelin signaling pathway 0 -0.460474308 -0.457142857 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Apelin signaling pathway 0 0.647233202 0.615186615 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Apelin signaling pathway 0.50173913 0.824110672 0.714543115 kegg kegg NA NA no no no no no no DNA replication Apelin signaling pathway 0.509565217 0.612648221 0.686743887 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Apelin signaling pathway 0 0.678853755 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Apelin signaling pathway 0 0.678853755 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Apelin signaling pathway 0.882608696 0.956521739 0.969369369 kegg kegg NA NA no no no no no no Endocytosis Apelin signaling pathway -0.415652174 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Apelin signaling pathway 0 -0.428853755 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Apelin signaling pathway 0.443478261 0 0.512483912 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Apelin signaling pathway 0 -0.707509881 0 kegg kegg NA NA no no no no no no Fatty acid degradation Apelin signaling pathway 0 -0.540513834 0 kegg kegg NA NA no no no no no no Fatty acid elongation Apelin signaling pathway 0 0.428853755 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Apelin signaling pathway 0 -0.498023715 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Apelin signaling pathway 0 -0.638339921 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Apelin signaling pathway 0 -0.679841897 0 kegg kegg NA NA no no no no no no Galactose metabolism Apelin signaling pathway 0 -0.725296443 0 kegg kegg NA NA no no no no no no Glutathione metabolism Apelin signaling pathway 0 0.738142292 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Apelin signaling pathway 0 -0.653162055 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Apelin signaling pathway 0 -0.5 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Apelin signaling pathway 0 0.416996047 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Apelin signaling pathway 0 0.71541502 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Apelin signaling pathway 0 -0.808300395 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Apelin signaling pathway 0 -0.581027668 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - globo and isoglobo series Apelin signaling pathway 0 0 -0.428571429 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Apelin signaling pathway 0 -0.494071146 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Apelin signaling pathway 0 -0.605731225 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Apelin signaling pathway 0.87826087 0.931818182 0.918661519 kegg kegg NA NA no no no no no no Homologous recombination Apelin signaling pathway 0 0 0.462290862 kegg kegg NA NA no no no no no no Lysine degradation Apelin signaling pathway 0.533043478 0 0 kegg kegg NA NA no no no no no no Lysosome Apelin signaling pathway -0.460869565 0 -0.415186615 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Apelin signaling pathway 0 0.622529644 0 kegg kegg NA NA no no no no no no Mismatch repair Apelin signaling pathway 0 0.558300395 0.58970399 kegg kegg NA NA no no no no no no Mitophagy - animal Apelin signaling pathway 0.465217391 0.59486166 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Apelin signaling pathway 0.51826087 0.567193676 0.474131274 kegg kegg NA NA no no no no no no mTOR signaling pathway Apelin signaling pathway 0.920869565 0.949604743 0.90965251 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Apelin signaling pathway 0.477391304 0.651185771 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Apelin signaling pathway 0 -0.454545455 0 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Apelin signaling pathway 0 -0.788537549 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Apelin signaling pathway 0 -0.759881423 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Apelin signaling pathway -0.432173913 -0.552371542 -0.488030888 kegg kegg NA NA no no no no no no Non-homologous end-joining Apelin signaling pathway 0 0.530632411 0.448133848 kegg kegg NA NA no no no no no no Notch signaling pathway Apelin signaling pathway 0 -0.458498024 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Apelin signaling pathway 0.464347826 0.485177866 0.614929215 kegg kegg NA NA no no no no no no One carbon pool by folate Apelin signaling pathway 0 0 0.44967825 kegg kegg NA NA no no no no no no Oocyte meiosis Apelin signaling pathway 0.548695652 0.718379447 0.44967825 kegg kegg NA NA no no no no no no Other glycan degradation Apelin signaling pathway 0 -0.581027668 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Apelin signaling pathway 0.440869565 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Apelin signaling pathway 0 0.736166008 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Apelin signaling pathway 0 -0.75 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Apelin signaling pathway 0 0.651185771 0.584041184 kegg kegg NA NA no no no no no no Pentose phosphate pathway Apelin signaling pathway -0.484347826 -0.517786561 0 kegg kegg NA NA no no no no no no Peroxisome Apelin signaling pathway 0 -0.631422925 0 kegg kegg NA NA no no no no no no Phagosome Apelin signaling pathway -0.61826087 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Apelin signaling pathway 0 0.447628458 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Apelin signaling pathway -0.472173913 -0.816205534 -0.629086229 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Apelin signaling pathway 0.613913043 0.503952569 0.887516088 yes kegg kegg NA NA no up up no no no PPAR signaling pathway Apelin signaling pathway 0 -0.533596838 0 kegg kegg NA NA no no no no no no Propanoate metabolism Apelin signaling pathway 0 0.826086957 0.776319176 kegg kegg NA NA no no no no no no Proteasome Apelin signaling pathway 0.435652174 0.583992095 0.548262548 kegg kegg NA NA no no no no no no Protein export Apelin signaling pathway 0.686086957 0.792490119 0.658429858 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Apelin signaling pathway 0.567826087 0.694664032 0.569111969 kegg kegg NA NA no no no no no no Pyruvate metabolism Apelin signaling pathway 0 0.865612648 0.649163449 kegg kegg NA NA no no no no no no Rap1 signaling pathway Apelin signaling pathway -0.486956522 0 0 kegg kegg NA NA no no no no no no Ras signaling pathway Apelin signaling pathway 0 0.586956522 0 yes kegg kegg NA NA no up up no no no Retinol metabolism Apelin signaling pathway 0 0 0.408494208 kegg kegg NA NA no no no no no no Ribosome Apelin signaling pathway 0.702608696 0.923913043 0.839382239 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Apelin signaling pathway 0.632173913 0 0.574259974 kegg kegg NA NA no no no no no no RNA degradation Apelin signaling pathway 0.54173913 0.707509881 0.572972973 kegg kegg NA NA no no no no no no RNA polymerase Apelin signaling pathway 0.575652174 0.595849802 0.638610039 kegg kegg NA NA no no no no no no RNA transport Apelin signaling pathway 0.526956522 0.906126482 0.726126126 kegg kegg NA NA no no no no no no Selenocompound metabolism Apelin signaling pathway 0.453043478 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Apelin signaling pathway 0 -0.685770751 0 kegg kegg NA NA no no no no no no Spliceosome Apelin signaling pathway 0.577391304 0 0.51042471 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Apelin signaling pathway 0 -0.793478261 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Apelin signaling pathway 0.410434783 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Apelin signaling pathway 0 0.435770751 0.470785071 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Apelin signaling pathway 0 -0.533596838 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Apelin signaling pathway 0.516521739 0 0.465637066 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Apelin signaling pathway 0.406086957 0.782608696 0 kegg kegg NA NA no no no no no no Thiamine metabolism Apelin signaling pathway 0 0.781620553 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Apelin signaling pathway 0 0.429841897 0.490604891 kegg kegg NA NA no up no no no no Tyrosine metabolism Apelin signaling pathway 0 0.558300395 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Apelin signaling pathway 0 0 0.510682111 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Apelin signaling pathway 0.506956522 0.623517787 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Apelin signaling pathway 0 0.494071146 0.562934363 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Apelin signaling pathway 0.593913043 0.511857708 0.404118404 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Apelin signaling pathway 0.445217391 0.608695652 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Apelin signaling pathway 0 -0.450592885 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Apelin signaling pathway 0 0.638339921 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Apoptosis 0 -0.518774704 0 kegg kegg NA NA no no no no no no Akkermansia Apoptosis 0 0 0.41151793 acetate-producing Genus kegg 0.23 NA no no no no no no "Alanine, aspartate and glutamate metabolism" Apoptosis 0 0.612648221 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Apoptosis 0.58173913 0.434782609 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Apoptosis 0 -0.532608696 -0.489317889 kegg kegg NA NA no no no no no no AMPK signaling pathway Apoptosis 0 -0.536561265 0 kegg kegg NA NA no no no no no no Antifolate resistance Apoptosis 0 -0.5256917 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Apoptosis 0.502608696 0.690711462 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Apoptosis 0 0.619565217 0.5003861 kegg kegg NA NA no no no no no no Autophagy - animal Apoptosis 0 0.633399209 0 kegg kegg NA NA no no no no no no Autophagy - other Apoptosis -0.42 0 -0.474388674 kegg kegg NA NA no no no no no no Basal transcription factors Apoptosis -0.684347826 -0.650197628 -0.748777349 kegg kegg NA NA no no no no no no Base excision repair Apoptosis -0.486956522 -0.652173913 -0.722779923 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Apoptosis 0.6 0.660079051 0.653024453 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Apoptosis 0 -0.871541502 0 kegg kegg NA NA no no no no no no Butanoate metabolism Apoptosis 0 -0.734189723 -0.427541828 kegg kegg NA NA no no no no no no Calcium signaling pathway Apoptosis -0.52173913 0 -0.404375804 kegg kegg NA NA no up up no no no cAMP signaling pathway Apoptosis 0 0.601778656 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Apoptosis 0.45826087 0 0.456885457 kegg kegg NA NA no no no no no no Cell cycle Apoptosis -0.585217391 -0.802371542 -0.645302445 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Apoptosis 0 0.764822134 0.404890605 kegg kegg NA NA no no no no no no Chemokine signaling pathway Apoptosis 0 0.681818182 0.636808237 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Apoptosis 0 -0.71541502 -0.475933076 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Apoptosis 0 -0.787549407 -0.61981982 kegg kegg NA NA no no no no no no DNA replication Apoptosis -0.48173913 -0.826086957 -0.681338481 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Apoptosis 0 -0.744071146 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Apoptosis 0 -0.609683794 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Apoptosis -0.477391304 -0.648221344 -0.605405405 kegg kegg NA NA no no no no no no Endocrine resistance Apoptosis -0.442608696 0 0 kegg kegg NA NA no no no no no no Endocytosis Apoptosis 0.506956522 0.718379447 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Apoptosis 0 -0.578063241 -0.421879022 kegg kegg NA NA no no no no no no Fanconi anemia pathway Apoptosis 0 -0.588932806 -0.657657658 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Apoptosis 0 0.666996047 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Apoptosis 0.539130435 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Apoptosis 0.642608696 0.522727273 0 kegg kegg NA NA no no no no no no Glutathione metabolism Apoptosis 0 -0.753952569 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Apoptosis 0 -0.756916996 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Apoptosis 0 -0.468379447 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Apoptosis 0.543478261 0.672924901 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Apoptosis -0.410434783 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Apoptosis 0.533913043 0.68972332 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Apoptosis 0 -0.424901186 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Apoptosis 0 0.490118577 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Apoptosis 0 -0.506916996 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Apoptosis 0 0.645256917 0.478507079 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Apoptosis -0.485217391 -0.570158103 -0.453024453 kegg kegg NA NA no no no no no no Homologous recombination Apoptosis 0 0 -0.631402831 kegg kegg NA NA no no no no no no Lysine degradation Apoptosis 0 0 -0.555212355 kegg kegg NA NA no no no no no no Lysosome Apoptosis 0.573043478 0.684782609 0.701415701 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Apoptosis 0 0 -0.469498069 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Apoptosis 0 -0.647233202 0 kegg kegg NA NA no no no no no no Mismatch repair Apoptosis 0 -0.809288538 -0.505791506 kegg kegg NA NA no no no no no no Mitophagy - animal Apoptosis 0 -0.48715415 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Apoptosis -0.599130435 -0.579051383 -0.668983269 kegg kegg NA NA no no no no no no mTOR signaling pathway Apoptosis -0.495652174 -0.654150198 -0.571428571 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Apoptosis -0.646086957 -0.746047431 -0.591505792 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Apoptosis 0.463478261 0.562252964 0.62985843 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Apoptosis 0 0.718379447 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Apoptosis 0 0.753952569 0.503989704 kegg kegg NA NA no no no no no no Nitrogen metabolism Apoptosis 0.508695652 0.556324111 0.416216216 kegg kegg NA NA no no no no no no Non-homologous end-joining Apoptosis 0 -0.506916996 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Apoptosis -0.486086957 -0.831027668 -0.665122265 kegg kegg NA NA no no no no no no One carbon pool by folate Apoptosis -0.428695652 -0.799407115 -0.564993565 kegg kegg NA NA no no no no no no Oocyte meiosis Apoptosis -0.648695652 -0.650197628 -0.550836551 kegg kegg NA NA no no no no no no Other glycan degradation Apoptosis 0.432173913 0 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Apoptosis -0.522608696 0 -0.576833977 kegg kegg NA NA no no no no no no Oxidative phosphorylation Apoptosis -0.432173913 -0.556324111 0 kegg kegg NA NA no no no no no no p53 signaling pathway Apoptosis -0.519130435 0 -0.527927928 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Apoptosis 0 0.640316206 0 kegg kegg NA NA no no dn no no no Parabacteroides Apoptosis 0 0 0.404916662 Genus kegg 4.19E-05 NA no up up no no no Pentose and glucuronate interconversions Apoptosis 0 -0.717391304 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Apoptosis 0.8 0.700592885 0.612355212 kegg kegg NA NA no no no no no no Peroxisome Apoptosis 0 0.483201581 0 kegg kegg NA NA no no no no no no Phagosome Apoptosis 0.619130435 0.70256917 0.64967825 kegg kegg NA NA no no no no no no Phenylalanine metabolism Apoptosis 0 -0.539525692 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Apoptosis -0.602608696 -0.488142292 -0.536422136 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Apoptosis 0 0.705533597 0 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Apoptosis 0 0 -0.594079794 yes kegg kegg NA NA no up up no no no Platinum drug resistance Apoptosis -0.469565217 0 -0.404890605 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Apoptosis 0 -0.691699605 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Apoptosis 0 0.753952569 0.489317889 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Apoptosis 0 -0.419960474 0 kegg kegg NA NA no no no no no no Propanoate metabolism Apoptosis 0 -0.76284585 -0.586357786 kegg kegg NA NA no no no no no no Proteasome Apoptosis 0 -0.503952569 0 kegg kegg NA NA no no no no no no Protein export Apoptosis -0.777391304 -0.619565217 -0.586100386 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Apoptosis -0.553043478 -0.767786561 -0.575804376 kegg kegg NA NA no no no no no no Purine metabolism Apoptosis 0 -0.679841897 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Apoptosis 0 -0.720355731 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Apoptosis 0 -0.855731225 -0.563191763 kegg kegg NA NA no no no no no no Rap1 signaling pathway Apoptosis 0.556521739 0 0.579407979 kegg kegg NA NA no no no no no no Ras signaling pathway Apoptosis 0 -0.600790514 -0.45997426 yes kegg kegg NA NA no up up no no no Retinol metabolism Apoptosis 0 -0.630434783 0 kegg kegg NA NA no no no no no no Ribosome Apoptosis -0.646086957 -0.628458498 -0.443758044 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Apoptosis -0.674782609 -0.727272727 -0.738223938 kegg kegg NA NA no no no no no no RNA degradation Apoptosis -0.603478261 -0.663043478 -0.623166023 kegg kegg NA NA no no no no no no RNA polymerase Apoptosis -0.807826087 -0.800395257 -0.663320463 kegg kegg NA NA no no no no no no RNA transport Apoptosis 0 -0.555335968 -0.520978121 kegg kegg NA NA no no no no no no Sarcina Apoptosis 0 0.444554224 0 Genus kegg 0.0703 NA no no no no no no Selenocompound metabolism Apoptosis -0.452173913 0 -0.517117117 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Apoptosis 0 0.454545455 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Apoptosis 0.57826087 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Apoptosis 0 0.67687747 0 kegg kegg NA NA no no no no no no Spliceosome Apoptosis -0.486956522 0 -0.692406692 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Apoptosis 0.696521739 0.659090909 0.477734878 kegg kegg NA NA no no no no no no Steroid biosynthesis Apoptosis -0.725217391 -0.649209486 -0.402831403 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Apoptosis 0 -0.580039526 0 kegg kegg NA NA no no no no no no Sulfur metabolism Apoptosis 0 -0.559288538 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Apoptosis 0 -0.817193676 -0.58043758 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Apoptosis -0.58173913 -0.46541502 -0.522522523 kegg kegg NA NA no no no no no no Thiamine metabolism Apoptosis 0 -0.767786561 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Apoptosis 0 -0.499011858 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Apoptosis 0 -0.76284585 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Apoptosis 0 -0.677865613 -0.603346203 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Apoptosis -0.432173913 -0.602766798 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Apoptosis 0 -0.695652174 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Apoptosis -0.509565217 -0.627470356 -0.517117117 kegg kegg NA NA no no no no no no ABC transporters Apoptosis - multiple species 0 0.861660079 0 kegg kegg NA NA no up up no no no Amino sugar and nucleotide sugar metabolism Apoptosis - multiple species 0 0.595849802 0.417503218 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Apoptosis - multiple species 0.430434783 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Apoptosis - multiple species 0 0.435770751 0 kegg kegg NA NA no no no no no no Apoptosis Apoptosis - multiple species -0.506956522 0 0 kegg kegg NA NA no no no no no no Autophagy - animal Apoptosis - multiple species 0.477391304 0.47826087 0.437323037 kegg kegg NA NA no no no no no no Autophagy - other Apoptosis - multiple species 0.476521739 0.710474308 0 kegg kegg NA NA no no no no no no Basal transcription factors Apoptosis - multiple species 0.665217391 0.585968379 0.494208494 kegg kegg NA NA no no no no no no Base excision repair Apoptosis - multiple species 0.824347826 0.639328063 0.516087516 kegg kegg NA NA no no no no no no Carbon metabolism Apoptosis - multiple species 0 -0.492094862 0 kegg kegg NA NA no no no no no no Cell cycle Apoptosis - multiple species 0.502608696 0.463438735 0.442985843 kegg kegg NA NA no no no no no no Chemokine signaling pathway Apoptosis - multiple species -0.428695652 0 -0.583011583 kegg kegg NA NA no no no no no no DNA replication Apoptosis - multiple species 0.539130435 0 0 kegg kegg NA NA no no no no no no Endocytosis Apoptosis - multiple species 0 0 -0.642471042 kegg kegg NA NA no no no no no no ErbB signaling pathway Apoptosis - multiple species 0.429565217 0.461462451 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Apoptosis - multiple species 0.605217391 0.675889328 0.546718147 kegg kegg NA NA no no no no no no Fatty acid degradation Apoptosis - multiple species 0 0.443675889 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Apoptosis - multiple species 0.47826087 0.7756917 0.697554698 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Apoptosis - multiple species 0 0.472332016 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Apoptosis - multiple species 0 0.799407115 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Apoptosis - multiple species 0.536521739 0.816205534 0.424195624 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Apoptosis - multiple species 0 -0.510869565 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Apoptosis - multiple species 0 0.457509881 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Apoptosis - multiple species -0.717391304 0 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Apoptosis - multiple species 0 0.433794466 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Apoptosis - multiple species -0.577391304 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Apoptosis - multiple species 0.499130435 0.583992095 0.427284427 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Apoptosis - multiple species 0 -0.466403162 0 kegg kegg NA NA no no no no no no Homologous recombination Apoptosis - multiple species 0.597391304 0.760869565 0.654826255 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Apoptosis - multiple species 0 0.873517787 0.581209781 kegg kegg NA NA no no no no no no Linoleic acid metabolism Apoptosis - multiple species -0.525217391 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Apoptosis - multiple species 0 0.489130435 0 kegg kegg NA NA no no no no no no Lysine degradation Apoptosis - multiple species 0.414782609 0.693675889 0.410553411 kegg kegg NA NA no no no no no no Lysosome Apoptosis - multiple species -0.524347826 -0.485177866 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Apoptosis - multiple species 0 0.539525692 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Apoptosis - multiple species 0 0.692687747 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Apoptosis - multiple species 0 0.606719368 0.442213642 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Apoptosis - multiple species 0.550434783 0 0.43989704 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Apoptosis - multiple species -0.432173913 0 0 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Apoptosis - multiple species 0.406956522 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Apoptosis - multiple species 0.566956522 0 0.512226512 kegg kegg NA NA no no no no no no One carbon pool by folate Apoptosis - multiple species 0.485217391 0 0 kegg kegg NA NA no no no no no no Other glycan degradation Apoptosis - multiple species 0 0.628458498 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Apoptosis - multiple species 0.466086957 0.756916996 0.597425997 kegg kegg NA NA no no no no no no Oxidative phosphorylation Apoptosis - multiple species 0 -0.4743083 0 kegg kegg NA NA no no no no no no p53 signaling pathway Apoptosis - multiple species 0.844347826 0.872529644 0.792020592 kegg kegg NA NA no no no no no no Pentose phosphate pathway Apoptosis - multiple species -0.522608696 0 0 kegg kegg NA NA no no no no no no Phagosome Apoptosis - multiple species 0 -0.421936759 -0.619305019 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Apoptosis - multiple species 0.405217391 0.609683794 0.469240669 kegg kegg NA NA no no no no no no Platinum drug resistance Apoptosis - multiple species 0.950434783 0.95256917 0.928700129 kegg kegg NA NA no no no no no no PPAR signaling pathway Apoptosis - multiple species 0 0 -0.523037323 kegg kegg NA NA no no no no no no Rap1 signaling pathway Apoptosis - multiple species -0.810434783 -0.683794466 -0.455341055 kegg kegg NA NA no no no no no no Retinol metabolism Apoptosis - multiple species 0 0 0.436550837 kegg kegg NA NA no no no no no no Ribosome Apoptosis - multiple species 0 -0.518774704 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Apoptosis - multiple species 0.725217391 0.484189723 0.421621622 kegg kegg NA NA no no no no no no RNA polymerase Apoptosis - multiple species 0.674782609 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Apoptosis - multiple species 0.737391304 0.808300395 0.654311454 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Apoptosis - multiple species 0 0.619565217 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Apoptosis - multiple species -0.551304348 0 0 kegg kegg NA NA no no no no no no Spliceosome Apoptosis - multiple species 0.715652174 0.829051383 0.499099099 kegg kegg NA NA no no no no no no Steroid biosynthesis Apoptosis - multiple species 0 0 0.413127413 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Apoptosis - multiple species 0.613913043 0.651185771 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Apoptosis - multiple species 0.446956522 0.52173913 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Apoptosis - multiple species 0.494782609 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Apoptosis - multiple species 0 0 -0.401029601 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Arachidonic acid metabolism 0.411304348 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Arachidonic acid metabolism 0.413043478 0 0 kegg kegg NA NA no no no no no no Collinsella Arachidonic acid metabolism 0 0 0.448610227 Genus kegg 0.128 NA no no no no no no Glutathione metabolism Arachidonic acid metabolism 0.856521739 0.456521739 0.855855856 kegg kegg NA NA no no no no no no Glycerolipid metabolism Arachidonic acid metabolism 0 0 -0.461261261 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Arachidonic acid metabolism 0 0 -0.480823681 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Arachidonic acid metabolism 0.455652174 0 0.676705277 kegg kegg NA NA no up no no no no Inositol phosphate metabolism Arachidonic acid metabolism 0 0 -0.444015444 kegg kegg NA NA no no no no no no Lysine degradation Arachidonic acid metabolism 0 0 -0.531016731 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Arachidonic acid metabolism 0 -0.463438735 -0.477734878 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Arachidonic acid metabolism 0 -0.482213439 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Arachidonic acid metabolism 0 0 -0.578378378 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Arachidonic acid metabolism 0 0 -0.4998713 kegg kegg NA NA no no no no no no Paraprevotella Arachidonic acid metabolism 0 0 0.425415742 Genus kegg 0.118 NA no no no no no no Phenylalanine metabolism Arachidonic acid metabolism 0.405217391 0 0 kegg kegg NA NA no no no no no no Purine metabolism Arachidonic acid metabolism 0.532173913 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Arachidonic acid metabolism 0.545217391 0 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Arachidonic acid metabolism 0 0 -0.410810811 kegg kegg NA NA no no no no no no Tryptophan metabolism Arachidonic acid metabolism 0.430434783 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Arachidonic acid metabolism 0.533043478 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Arachidonic acid metabolism 0.454782609 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Arachidonic acid metabolism 0 0 -0.67001287 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Arginine and proline metabolism 0.745217391 0.873517787 0.552380952 kegg kegg NA NA no no no no up no Arginine biosynthesis Arginine and proline metabolism 0.786956522 0.85770751 0.58996139 kegg kegg NA NA no no no no up no Blautia Arginine and proline metabolism 0.422608696 0 0 acetate-producing Genus kegg 1.36E-05 NA up dn dn no up no Citrate cycle (TCA cycle) Arginine and proline metabolism 0 -0.634387352 0 kegg kegg NA NA no no no no up no Cysteine and methionine metabolism Arginine and proline metabolism 0 -0.640316206 -0.53951094 kegg kegg NA NA no no no no up no Fatty acid biosynthesis Arginine and proline metabolism 0.793913043 0.840909091 0.633719434 kegg kegg NA NA no no no no up no Fatty acid degradation Arginine and proline metabolism 0.647826087 0.639328063 0 kegg kegg NA NA no no no no up no Galactose metabolism Arginine and proline metabolism 0.415652174 0.469367589 0 kegg kegg NA NA no no no no up no "Glycine, serine and threonine metabolism" Arginine and proline metabolism -0.454782609 0 0 kegg kegg NA NA no up no no up no Glycolysis / Gluconeogenesis Arginine and proline metabolism 0 -0.5256917 0 kegg kegg NA NA no no no no up no Odoribacter Arginine and proline metabolism 0.474395625 0 0 butyrate-producing Genus kegg 0.798 NA no no no no up no Oxidative phosphorylation Arginine and proline metabolism 0 -0.776679842 -0.574002574 kegg kegg NA NA no no no no up no Paraprevotella Arginine and proline metabolism 0 -0.470822224 0 Genus kegg 0.118 NA no no no no up no Pentose and glucuronate interconversions Arginine and proline metabolism 0 -0.745059289 -0.454311454 kegg kegg NA NA no no no no up no Pentose phosphate pathway Arginine and proline metabolism 0.427826087 0.652173913 0.613384813 kegg kegg NA NA no no no no up no Purine metabolism Arginine and proline metabolism 0 -0.451581028 0 kegg kegg NA NA no no no no up no Pyrimidine metabolism Arginine and proline metabolism 0 -0.62055336 0 kegg kegg NA NA no no no no up no Slackia Arginine and proline metabolism 0 0 -0.420317831 Genus kegg 0.94 NA no no no no up no Steroid biosynthesis Arginine and proline metabolism -0.422608696 -0.464426877 -0.588159588 kegg kegg NA NA no no no no up no Synthesis and degradation of ketone bodies Arginine and proline metabolism 0 -0.542490119 0 kegg kegg NA NA no no no no up no Ubiquinone and other terpenoid-quinone biosynthesis Arginine and proline metabolism 0 -0.457509881 0 kegg kegg NA NA no no no no up no "Valine, leucine and isoleucine degradation" Arginine and proline metabolism 0 -0.56916996 0 kegg kegg NA NA no no no no up no Ascorbate and aldarate metabolism Arginine biosynthesis 0 -0.527667984 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Arginine biosynthesis 0 -0.671936759 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Arginine biosynthesis 0.907826087 0.93972332 0.738481338 kegg kegg NA NA no no no no no no Fatty acid degradation Arginine biosynthesis 0.726086957 0.747035573 0 kegg kegg NA NA no no no no no no Galactose metabolism Arginine biosynthesis 0.415652174 0.523715415 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Arginine biosynthesis 0 -0.469367589 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Arginine biosynthesis -0.547826087 -0.71541502 -0.466666667 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Arginine biosynthesis 0 -0.840909091 -0.631660232 kegg kegg NA NA no no no no no no Pentose phosphate pathway Arginine biosynthesis 0.519130435 0.637351779 0.762162162 kegg kegg NA NA no no no no no no Steroid biosynthesis Arginine biosynthesis -0.444347826 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Arginine biosynthesis 0 -0.418972332 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Arginine biosynthesis 0 -0.431818182 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Arginine biosynthesis 0 -0.489130435 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Arrhythmogenic right ventricular cardiomyopathy 0.415652174 0.571146245 0 kegg kegg NA NA no no no no up up ABC transporters Arrhythmogenic right ventricular cardiomyopathy 0 -0.455533597 0 kegg kegg NA NA no up up no up up Acute myeloid leukemia Arrhythmogenic right ventricular cardiomyopathy 0 -0.438735178 0 kegg kegg NA NA no no no no up up Adherens junction Arrhythmogenic right ventricular cardiomyopathy 0.92 0.945652174 0.964221364 kegg kegg NA NA no no no no up up Adipocytokine signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.612648221 0 kegg kegg NA NA no no no no up up Adrenergic signaling in cardiomyocytes Arrhythmogenic right ventricular cardiomyopathy 0 0.433794466 0 kegg kegg NA NA no no up no up up AGE-RAGE signaling pathway in diabetic complications Arrhythmogenic right ventricular cardiomyopathy 0 -0.625494071 0 kegg kegg NA NA no no no no up up "Alanine, aspartate and glutamate metabolism" Arrhythmogenic right ventricular cardiomyopathy 0 -0.718379447 0 kegg kegg NA NA no no no no up up Allograft rejection Arrhythmogenic right ventricular cardiomyopathy 0.406956522 0 0 kegg kegg NA NA no no no no up up alpha-Linolenic acid metabolism Arrhythmogenic right ventricular cardiomyopathy 0 -0.41798419 0 kegg kegg NA NA no no no no up up Alzheimer disease Arrhythmogenic right ventricular cardiomyopathy 0 0.605731225 0.459202059 kegg kegg NA NA no no no no up up Amoebiasis Arrhythmogenic right ventricular cardiomyopathy 0 -0.416007905 0 kegg kegg NA NA no no no no up up Amphetamine addiction Arrhythmogenic right ventricular cardiomyopathy 0 0.442687747 0 kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis Arrhythmogenic right ventricular cardiomyopathy 0 0.644268775 0.616216216 kegg kegg NA NA no no no no up up Apelin signaling pathway Arrhythmogenic right ventricular cardiomyopathy -0.452173913 0.46541502 0 kegg kegg NA NA no no no no up up Apoptosis Arrhythmogenic right ventricular cardiomyopathy 0.530434783 0 0.412355212 kegg kegg NA NA no no no no up up Apoptosis - multiple species Arrhythmogenic right ventricular cardiomyopathy -0.604347826 -0.486166008 0 kegg kegg NA NA no no no no up up Arginine and proline metabolism Arrhythmogenic right ventricular cardiomyopathy 0 -0.646245059 -0.405148005 kegg kegg NA NA no up no no up up Arginine biosynthesis Arrhythmogenic right ventricular cardiomyopathy 0 -0.663043478 0 kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism Arrhythmogenic right ventricular cardiomyopathy 0 0.479249012 0 kegg kegg NA NA no no no no up up Asthma Arrhythmogenic right ventricular cardiomyopathy 0 0.489130435 0 kegg kegg NA NA no no no no up up Autoimmune thyroid disease Arrhythmogenic right ventricular cardiomyopathy 0.406956522 0 0 kegg kegg NA NA no no no no up up Autophagy - animal Arrhythmogenic right ventricular cardiomyopathy -0.728695652 -0.893280632 -0.53951094 kegg kegg NA NA no no no no up up Autophagy - other Arrhythmogenic right ventricular cardiomyopathy -0.876521739 -0.740118577 -0.511454311 kegg kegg NA NA no no no no up up B cell receptor signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.583003953 0 kegg kegg NA NA no no no no up up Bacterial invasion of epithelial cells Arrhythmogenic right ventricular cardiomyopathy 0.905217391 0.861660079 0.919176319 kegg kegg NA NA no no no no up up Basal transcription factors Arrhythmogenic right ventricular cardiomyopathy -0.72173913 0 0 kegg kegg NA NA no no no no up up Base excision repair Arrhythmogenic right ventricular cardiomyopathy -0.544347826 0 0 kegg kegg NA NA no no no no up up beta-Alanine metabolism Arrhythmogenic right ventricular cardiomyopathy 0.435652174 0 0 kegg kegg NA NA no no no no up up Bifidobacterium Arrhythmogenic right ventricular cardiomyopathy 0 0.464587854 0 acetate-producing Genus kegg 0.105 NA no dn no no up up Bile secretion Arrhythmogenic right ventricular cardiomyopathy 0 0.440711462 0 kegg kegg NA NA no no no no up up Biosynthesis of cofactors Arrhythmogenic right ventricular cardiomyopathy 0.427826087 0 0 kegg kegg NA NA no no no no up up Bladder cancer Arrhythmogenic right ventricular cardiomyopathy 0 -0.610671937 0 kegg kegg NA NA no no no no up up Breast cancer Arrhythmogenic right ventricular cardiomyopathy 0 -0.691699605 0 kegg kegg NA NA no no no no up up Butanoate metabolism Arrhythmogenic right ventricular cardiomyopathy 0 0.541501976 0 kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway Arrhythmogenic right ventricular cardiomyopathy -0.505217391 -0.683794466 -0.549034749 kegg kegg NA NA no no no no up up Calcium signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 0.45256917 0 kegg kegg NA NA no up up no up up Carbohydrate digestion and absorption Arrhythmogenic right ventricular cardiomyopathy -0.487826087 -0.458498024 0 kegg kegg NA NA no no no no up up Carbon metabolism Arrhythmogenic right ventricular cardiomyopathy 0.430434783 0 0 kegg kegg NA NA no no no no up up Cardiac muscle contraction Arrhythmogenic right ventricular cardiomyopathy 0 0.636363636 0.56036036 kegg kegg NA NA no no up no up up Cell adhesion molecules Arrhythmogenic right ventricular cardiomyopathy 0.427826087 0 0 kegg kegg NA NA no no no no up up Cell cycle Arrhythmogenic right ventricular cardiomyopathy -0.410434783 0 0 kegg kegg NA NA no no no no up up Chagas disease Arrhythmogenic right ventricular cardiomyopathy 0 -0.606719368 0 kegg kegg NA NA no no no no up up Choline metabolism in cancer Arrhythmogenic right ventricular cardiomyopathy -0.466086957 -0.528656126 0 kegg kegg NA NA no no no no up up Cholinergic synapse Arrhythmogenic right ventricular cardiomyopathy -0.459130435 0 0 kegg kegg NA NA no no no no up up Chronic myeloid leukemia Arrhythmogenic right ventricular cardiomyopathy 0 -0.553359684 -0.535135135 kegg kegg NA NA no no no no up up Circadian entrainment Arrhythmogenic right ventricular cardiomyopathy 0 0.666996047 0 kegg kegg NA NA no up up no up up Circadian rhythm Arrhythmogenic right ventricular cardiomyopathy -0.65826087 0 0 kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) Arrhythmogenic right ventricular cardiomyopathy 0 0.536561265 0 kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Arrhythmogenic right ventricular cardiomyopathy 0 0.466403162 0 kegg kegg NA NA no no no no up up Cysteine and methionine metabolism Arrhythmogenic right ventricular cardiomyopathy 0 0.434782609 0 kegg kegg NA NA no no no no up up Cytokine-cytokine receptor interaction Arrhythmogenic right ventricular cardiomyopathy 0 0 0.651480051 kegg kegg NA NA no no no no up up Cytosolic DNA-sensing pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.455533597 0 kegg kegg NA NA no no no no up up DNA replication Arrhythmogenic right ventricular cardiomyopathy 0 0.480237154 0 kegg kegg NA NA no no no no up up Dopaminergic synapse Arrhythmogenic right ventricular cardiomyopathy 0 0.552371542 0 kegg kegg NA NA no up no no up up Drug metabolism - cytochrome P450 Arrhythmogenic right ventricular cardiomyopathy 0 0.694664032 0 kegg kegg NA NA no no no no up up Drug metabolism - other enzymes Arrhythmogenic right ventricular cardiomyopathy 0 0.753952569 0 kegg kegg NA NA no no no no up up EGFR tyrosine kinase inhibitor resistance Arrhythmogenic right ventricular cardiomyopathy -0.416521739 0 0 kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Arrhythmogenic right ventricular cardiomyopathy 0 0.530632411 0 kegg kegg NA NA no no no no up up Endometrial cancer Arrhythmogenic right ventricular cardiomyopathy 0 -0.611660079 0 kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection Arrhythmogenic right ventricular cardiomyopathy 0 -0.494071146 0 kegg kegg NA NA no no no no up up ErbB signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.51284585 0 kegg kegg NA NA no no no no up up Estrogen signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 0.502964427 0 kegg kegg NA NA no no no no up up Fatty acid biosynthesis Arrhythmogenic right ventricular cardiomyopathy 0 -0.634387352 0 kegg kegg NA NA no no no no up up Fatty acid degradation Arrhythmogenic right ventricular cardiomyopathy 0 -0.566205534 0 kegg kegg NA NA no no no no up up Fatty acid metabolism Arrhythmogenic right ventricular cardiomyopathy 0 -0.522727273 0 kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.552371542 0 kegg kegg NA NA no no no no up up Focal adhesion Arrhythmogenic right ventricular cardiomyopathy 0.891304348 0.927865613 0.907335907 kegg kegg NA NA no up up no up up Folate biosynthesis Arrhythmogenic right ventricular cardiomyopathy 0 0.447628458 0 kegg kegg NA NA no no no no up up FoxO signaling pathway Arrhythmogenic right ventricular cardiomyopathy -0.417391304 -0.694664032 0 kegg kegg NA NA no no no no up up GABAergic synapse Arrhythmogenic right ventricular cardiomyopathy -0.419130435 -0.556324111 0 kegg kegg NA NA no up up no up up Galactose metabolism Arrhythmogenic right ventricular cardiomyopathy 0.455652174 0 0 kegg kegg NA NA no no no no up up Gap junction Arrhythmogenic right ventricular cardiomyopathy 0.44 0 0 kegg kegg NA NA no no no no up up Gastric acid secretion Arrhythmogenic right ventricular cardiomyopathy 0.883478261 0.946640316 0.906048906 kegg kegg NA NA no no no no up up Glioma Arrhythmogenic right ventricular cardiomyopathy -0.495652174 -0.433794466 0 kegg kegg NA NA no no no no up up Glucagon signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 0.441699605 0 kegg kegg NA NA no no no no up up Glutathione metabolism Arrhythmogenic right ventricular cardiomyopathy 0 0.484189723 0 kegg kegg NA NA no no no no up up Glycerolipid metabolism Arrhythmogenic right ventricular cardiomyopathy 0 -0.485177866 0 kegg kegg NA NA no no up no up up Glycerophospholipid metabolism Arrhythmogenic right ventricular cardiomyopathy -0.429565217 -0.519762846 0 kegg kegg NA NA no no up no up up Glycolysis / Gluconeogenesis Arrhythmogenic right ventricular cardiomyopathy 0 0.575098814 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Arrhythmogenic right ventricular cardiomyopathy 0 -0.635375494 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Arrhythmogenic right ventricular cardiomyopathy 0.574782609 0.445652174 0 kegg kegg NA NA no no no no up up Glyoxylate and dicarboxylate metabolism Arrhythmogenic right ventricular cardiomyopathy 0 -0.675889328 0 kegg kegg NA NA no no no no up up GnRH secretion Arrhythmogenic right ventricular cardiomyopathy 0 -0.511857708 0 kegg kegg NA NA no up up no up up Hematopoietic cell lineage Arrhythmogenic right ventricular cardiomyopathy 0 0 0.506048906 kegg kegg NA NA no no no no up up Hepatitis B Arrhythmogenic right ventricular cardiomyopathy -0.593043478 -0.852766798 -0.488288288 kegg kegg NA NA no no no no up up Hepatitis C Arrhythmogenic right ventricular cardiomyopathy 0 -0.576086957 -0.43011583 kegg kegg NA NA no no no no up up Hepatocellular carcinoma Arrhythmogenic right ventricular cardiomyopathy 0.894782609 0.941699605 0.918661519 kegg kegg NA NA no no no no up up HIF-1 signaling pathway Arrhythmogenic right ventricular cardiomyopathy -0.506956522 0 0 kegg kegg NA NA no no no no up up Hippo signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0.863478261 0.929841897 0.937966538 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Arrhythmogenic right ventricular cardiomyopathy 0 -0.581027668 0 kegg kegg NA NA no no no no up up Huntington disease Arrhythmogenic right ventricular cardiomyopathy 0 0.615612648 0.537966538 kegg kegg NA NA no no no no up up Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy 0.982608696 0.985177866 0.992277992 kegg kegg NA NA no up up no up up Inflammatory mediator regulation of TRP channels Arrhythmogenic right ventricular cardiomyopathy 0 0.574110672 0 kegg kegg NA NA no no no no up up Influenza A Arrhythmogenic right ventricular cardiomyopathy 0.53826087 0 0.672844273 kegg kegg NA NA no no no no up up Inositol phosphate metabolism Arrhythmogenic right ventricular cardiomyopathy 0 -0.453557312 0 kegg kegg NA NA no no no no up up Insulin resistance Arrhythmogenic right ventricular cardiomyopathy -0.647826087 -0.707509881 -0.606949807 kegg kegg NA NA no no no no up up Insulin signaling pathway Arrhythmogenic right ventricular cardiomyopathy -0.50173913 0 0 kegg kegg NA NA no no no no up up JAK-STAT signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.703557312 0 kegg kegg NA NA no no no no up up Lachnospira Arrhythmogenic right ventricular cardiomyopathy 0 0.559426753 0 butyrate-producing Genus kegg 0.279 NA no no no no up up Leukocyte transendothelial migration Arrhythmogenic right ventricular cardiomyopathy 0.74173913 0.568181818 0.692664093 kegg kegg NA NA no no no no up up Long-term potentiation Arrhythmogenic right ventricular cardiomyopathy -0.544347826 0 0 kegg kegg NA NA no no up no up up Longevity regulating pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.445652174 0 kegg kegg NA NA no no no no up up Lysine degradation Arrhythmogenic right ventricular cardiomyopathy -0.406086957 0 0 kegg kegg NA NA no no no no up up Malaria Arrhythmogenic right ventricular cardiomyopathy 0 -0.419960474 0 kegg kegg NA NA no no no no up up MAPK signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.532608696 0 kegg kegg NA NA no no no no up up Melanogenesis Arrhythmogenic right ventricular cardiomyopathy 0 0.552371542 0 kegg kegg NA NA no no no no up up Melanoma Arrhythmogenic right ventricular cardiomyopathy -0.536521739 -0.711462451 -0.431660232 kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 Arrhythmogenic right ventricular cardiomyopathy 0 0.710474308 0 kegg kegg NA NA no no no no up up MicroRNAs in cancer Arrhythmogenic right ventricular cardiomyopathy 0 -0.779644269 0 kegg kegg NA NA no no no no up up Morphine addiction Arrhythmogenic right ventricular cardiomyopathy 0 0.508893281 0 kegg kegg NA NA no up up no up up mRNA surveillance pathway Arrhythmogenic right ventricular cardiomyopathy -0.522608696 0 0 kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis Arrhythmogenic right ventricular cardiomyopathy 0 -0.563241107 0 kegg kegg NA NA no no no no up up N-Glycan biosynthesis Arrhythmogenic right ventricular cardiomyopathy 0 0.574110672 0 kegg kegg NA NA no no no no up up Neurotrophin signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.578063241 0 kegg kegg NA NA no no no no up up NF-kappa B signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.767786561 -0.643243243 kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Arrhythmogenic right ventricular cardiomyopathy 0 -0.587944664 0 kegg kegg NA NA no no no no up up Nitrogen metabolism Arrhythmogenic right ventricular cardiomyopathy 0 -0.68083004 0 kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.760869565 0 kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease Arrhythmogenic right ventricular cardiomyopathy 0 0.517786561 0.502187902 kegg kegg NA NA no no no no up up Non-small cell lung cancer Arrhythmogenic right ventricular cardiomyopathy 0 -0.475296443 0 kegg kegg NA NA no no no no up up One carbon pool by folate Arrhythmogenic right ventricular cardiomyopathy 0 0.482213439 0 kegg kegg NA NA no no no no up up Oocyte meiosis Arrhythmogenic right ventricular cardiomyopathy -0.43826087 0 0 kegg kegg NA NA no no no no up up Osteoclast differentiation Arrhythmogenic right ventricular cardiomyopathy 0 -0.583992095 0 kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis Arrhythmogenic right ventricular cardiomyopathy -0.48173913 0 0 kegg kegg NA NA no no no no up up Ovarian steroidogenesis Arrhythmogenic right ventricular cardiomyopathy 0.446086957 0 0 kegg kegg NA NA no up up no up up Oxidative phosphorylation Arrhythmogenic right ventricular cardiomyopathy 0 0.621541502 0.558301158 kegg kegg NA NA no no no no up up Oxytocin signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0.882608696 0.719367589 0.648133848 kegg kegg NA NA no no no no up up p53 signaling pathway Arrhythmogenic right ventricular cardiomyopathy -0.720869565 -0.53458498 -0.427284427 kegg kegg NA NA no no no no up up Pancreatic secretion Arrhythmogenic right ventricular cardiomyopathy 0 0.609683794 0 kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis Arrhythmogenic right ventricular cardiomyopathy 0 -0.570158103 0 kegg kegg NA NA no no dn no up up Paraprevotella Arrhythmogenic right ventricular cardiomyopathy 0 0.417444123 0 Genus kegg 0.118 NA no no no no up up Parkinson disease Arrhythmogenic right ventricular cardiomyopathy 0 0.51284585 0 kegg kegg NA NA no no no no up up Pathogenic Escherichia coli infection Arrhythmogenic right ventricular cardiomyopathy 0.48173913 0 0.595366795 kegg kegg NA NA no no no no up up Pathways in cancer Arrhythmogenic right ventricular cardiomyopathy -0.530434783 -0.557312253 -0.433719434 kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases Arrhythmogenic right ventricular cardiomyopathy 0 0.479249012 0 kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer Arrhythmogenic right ventricular cardiomyopathy -0.499130435 -0.808300395 -0.54028314 kegg kegg NA NA no no no no up up Pentose and glucuronate interconversions Arrhythmogenic right ventricular cardiomyopathy 0 0.54743083 0 kegg kegg NA NA no no no no up up Pentose phosphate pathway Arrhythmogenic right ventricular cardiomyopathy 0.430434783 0 0 kegg kegg NA NA no no no no up up Peroxisome Arrhythmogenic right ventricular cardiomyopathy 0 -0.626482213 0 kegg kegg NA NA no no no no up up Phagosome Arrhythmogenic right ventricular cardiomyopathy 0.511304348 0 0.401801802 kegg kegg NA NA no no no no up up Phenylalanine metabolism Arrhythmogenic right ventricular cardiomyopathy 0.70173913 0.731225296 0.615444015 kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system Arrhythmogenic right ventricular cardiomyopathy -0.49826087 0 0 kegg kegg NA NA no no no no up up Phospholipase D signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.46541502 0 kegg kegg NA NA no up up no up up Phototransduction Arrhythmogenic right ventricular cardiomyopathy 0 0.523715415 0 kegg kegg NA NA no no no no up up Platelet activation Arrhythmogenic right ventricular cardiomyopathy 0.924347826 0.912055336 0.854568855 kegg kegg NA NA no no no no up up Platinum drug resistance Arrhythmogenic right ventricular cardiomyopathy -0.651304348 -0.429841897 0 kegg kegg NA NA no no no no up up PPAR signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.625494071 0 kegg kegg NA NA no no no no up up Prion disease Arrhythmogenic right ventricular cardiomyopathy 0 0.631422925 0.622908623 kegg kegg NA NA no no no no up up Progesterone-mediated oocyte maturation Arrhythmogenic right ventricular cardiomyopathy -0.596521739 0 0 kegg kegg NA NA no no no no up up Prolactin signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.52173913 0 kegg kegg NA NA no no no no up up Prostate cancer Arrhythmogenic right ventricular cardiomyopathy -0.474782609 -0.625494071 -0.530759331 kegg kegg NA NA no no no no up up Proteasome Arrhythmogenic right ventricular cardiomyopathy -0.600869565 0.505928854 0 kegg kegg NA NA no no no no up up Protein digestion and absorption Arrhythmogenic right ventricular cardiomyopathy 0 -0.536561265 0 yes kegg kegg NA NA no up up no up up Protein export Arrhythmogenic right ventricular cardiomyopathy -0.603478261 0.528656126 0 kegg kegg NA NA no no no no up up Protein processing in endoplasmic reticulum Arrhythmogenic right ventricular cardiomyopathy 0 0.45256917 0 kegg kegg NA NA no no no no up up Proteoglycans in cancer Arrhythmogenic right ventricular cardiomyopathy 0 0.539525692 0 kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation Arrhythmogenic right ventricular cardiomyopathy 0 0.542490119 0 kegg kegg NA NA no no no no up up Pyrimidine metabolism Arrhythmogenic right ventricular cardiomyopathy 0 0.540513834 0 kegg kegg NA NA no no no no up up Pyruvate metabolism Arrhythmogenic right ventricular cardiomyopathy 0 0.456521739 0 kegg kegg NA NA no no no no up up Rap1 signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0.864347826 0.820158103 0.814671815 kegg kegg NA NA no no no no up up Ras signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 0.590909091 0 yes kegg kegg NA NA no up up no up up Regulation of actin cytoskeleton Arrhythmogenic right ventricular cardiomyopathy 0.614782609 0.598814229 0.664092664 kegg kegg NA NA no no no no up up Renal cell carcinoma Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.502187902 kegg kegg NA NA no no no no up up Renin secretion Arrhythmogenic right ventricular cardiomyopathy 0 0.661067194 0 kegg kegg NA NA no no no no up up Retrograde endocannabinoid signaling Arrhythmogenic right ventricular cardiomyopathy 0 0.649209486 0.425997426 kegg kegg NA NA no no up no up up Rheumatoid arthritis Arrhythmogenic right ventricular cardiomyopathy 0 0 0.417245817 kegg kegg NA NA no no no no up up Ribosome Arrhythmogenic right ventricular cardiomyopathy 0 0.4743083 0 kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes Arrhythmogenic right ventricular cardiomyopathy -0.503478261 0 0 kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway Arrhythmogenic right ventricular cardiomyopathy -0.555652174 -0.801383399 -0.609009009 kegg kegg NA NA no no no no up up RNA degradation Arrhythmogenic right ventricular cardiomyopathy -0.519130435 0.442687747 0 kegg kegg NA NA no no no no up up RNA polymerase Arrhythmogenic right ventricular cardiomyopathy -0.640869565 0 0 kegg kegg NA NA no no no no up up Salivary secretion Arrhythmogenic right ventricular cardiomyopathy 0 0.568181818 0 kegg kegg NA NA no no no no up up Salmonella infection Arrhythmogenic right ventricular cardiomyopathy 0 0 0.620592021 kegg kegg NA NA no no no no up up Selenocompound metabolism Arrhythmogenic right ventricular cardiomyopathy -0.604347826 0 0 kegg kegg NA NA no no no no up up Small cell lung cancer Arrhythmogenic right ventricular cardiomyopathy -0.434782609 -0.688735178 -0.607464607 kegg kegg NA NA no no up no up up SNARE interactions in vesicular transport Arrhythmogenic right ventricular cardiomyopathy 0 -0.648221344 0 kegg kegg NA NA no no no no up up Spinocerebellar ataxia Arrhythmogenic right ventricular cardiomyopathy -0.846086957 0 0 kegg kegg NA NA no no no no up up Spliceosome Arrhythmogenic right ventricular cardiomyopathy -0.66173913 -0.463438735 0 kegg kegg NA NA no no no no up up Starch and sucrose metabolism Arrhythmogenic right ventricular cardiomyopathy 0 -0.563241107 0 kegg kegg NA NA no no no no up up Steroid hormone biosynthesis Arrhythmogenic right ventricular cardiomyopathy 0 0.459486166 0 kegg kegg NA NA no no no no up up Sulfur metabolism Arrhythmogenic right ventricular cardiomyopathy 0.428695652 0 0 kegg kegg NA NA no no no no up up T cell receptor signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.717391304 0 kegg kegg NA NA no no no no up up Taurine and hypotaurine metabolism Arrhythmogenic right ventricular cardiomyopathy 0 -0.550395257 0 kegg kegg NA NA no no no no up up Terpenoid backbone biosynthesis Arrhythmogenic right ventricular cardiomyopathy -0.497391304 0 0 kegg kegg NA NA no no no no up up TGF-beta signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 0.472332016 0 kegg kegg NA NA no no no no up up Thermogenesis Arrhythmogenic right ventricular cardiomyopathy 0 0.643280632 0.522007722 kegg kegg NA NA no no no no up up Thiamine metabolism Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.484169884 kegg kegg NA NA no no no no up up Thyroid hormone signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0.836521739 0.928853755 0.864092664 kegg kegg NA NA no no no no up up Tight junction Arrhythmogenic right ventricular cardiomyopathy 0.795652174 0.839920949 0.683912484 kegg kegg NA NA no no no no up up TNF signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.659090909 -0.407464607 kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 -0.638339921 0 yes kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Arrhythmogenic right ventricular cardiomyopathy -0.793913043 -0.868577075 -0.68983269 kegg kegg NA NA no no no no up up Tryptophan metabolism Arrhythmogenic right ventricular cardiomyopathy 0 0.447628458 0 kegg kegg NA NA no up no no up up Type I diabetes mellitus Arrhythmogenic right ventricular cardiomyopathy 0.406956522 0 0 kegg kegg NA NA no no no no up up Type II diabetes mellitus Arrhythmogenic right ventricular cardiomyopathy -0.440869565 -0.690711462 0 kegg kegg NA NA no no no no up up Tyrosine metabolism Arrhythmogenic right ventricular cardiomyopathy 0 0.593873518 0 kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" Arrhythmogenic right ventricular cardiomyopathy 0 0.5 0 kegg kegg NA NA no no no no up up Various types of N-glycan biosynthesis Arrhythmogenic right ventricular cardiomyopathy -0.437391304 0 0 kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Arrhythmogenic right ventricular cardiomyopathy 0 0.650197628 0 kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption Arrhythmogenic right ventricular cardiomyopathy 0 0.600790514 0 kegg kegg NA NA no no no no up up Vibrio cholerae infection Arrhythmogenic right ventricular cardiomyopathy 0.911304348 0.924901186 0.862033462 kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor Arrhythmogenic right ventricular cardiomyopathy 0 0 0.464350064 kegg kegg NA NA no no no no up up Wnt signaling pathway Arrhythmogenic right ventricular cardiomyopathy 0 0.549407115 0 kegg kegg NA NA no no no no up up Yersinia infection Arrhythmogenic right ventricular cardiomyopathy 0.512173913 0 0.71016731 kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) Ascorbate and aldarate metabolism 0.592173913 0.603754941 0.711454311 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Ascorbate and aldarate metabolism 0 0 0.53976834 kegg kegg NA NA no no no no no no Galactose metabolism Ascorbate and aldarate metabolism 0.513043478 0 0.576576577 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Ascorbate and aldarate metabolism 0.68 0.656126482 0.448391248 kegg kegg NA NA no no no no no no 14:0/18:2-PC+blood AST+clinic -0.500515996 0 0 serum_phospholipids clinic 0.102 0.113 no up no up no no 16:0-LPC+blood AST+clinic 0 0.571428571 0 serum_phospholipids clinic 0.00456 0.113 up up no up no no 16:0/16:0-PC+blood AST+clinic 0 0 -0.520769231 serum_phospholipids clinic 0.00079 0.113 no up up up no no 16:0/18:3-PC+blood AST+clinic 0 0.582142857 0 serum_phospholipids clinic 0.00216 0.113 no up up up no no 16:0/20:5-PC+blood AST+clinic -0.673890609 0 0 serum_phospholipids clinic 0.628 0.113 no no no up no no 16:1/18:2-PG+blood AST+clinic 0 0.639285714 0 serum_phospholipids clinic 1.40E-08 0.113 no up up up no no 16:1+blood AST+clinic 0 0 -0.402307692 yes serum_fattyacid clinic 0.0186 0.113 no no dn up no no 18:0/18:2-PI+blood AST+clinic 0 0.517857143 0 serum_phospholipids clinic 0.179 0.113 no no no up no no 18:1-LPC+blood AST+clinic 0.529411765 0 0.470769231 serum_phospholipids clinic 0.179 0.113 no no no up no no 18:1-LPE+blood AST+clinic 0 0 0.626153846 serum_phospholipids clinic 0.117 0.113 no no no up no no 18:2-LPC+blood AST+clinic 0.479876161 0 0.400769231 serum_phospholipids clinic 0.00743 0.113 dn no up up no no 18:2/20:4-PC+blood AST+clinic 0 0 0.514615385 serum_phospholipids clinic 0.0145 0.113 no no up up no no 20:1+blood AST+clinic 0.469556244 0 0 yes serum_fattyacid clinic 2.56E-05 0.113 dn dn dn up no no 20:2+blood AST+clinic 0.5500516 0 0 serum_fattyacid clinic 0.478 0.113 no no no up no no 20:5n3+blood AST+clinic -0.661506708 0 0 serum_fattyacid clinic 0.988 0.113 no no no up no no 24:1+blood AST+clinic 0 -0.585714286 0 serum_fattyacid clinic 0.00582 0.113 no dn dn up no no ACA+blood AST+clinic 0 -0.629360018 0 serum_bileacids clinic 0.338 0.113 no no no up no no Adipocytokine signaling pathway AST+clinic 0.531338227 0 0 kegg clinic NA 0.113 no no no up no no AGE-RAGE signaling pathway in diabetic complications AST+clinic 0 0.453246753 0 kegg clinic NA 0.113 no no no up no no Alcoholism AST+clinic 0.506493506 0 0 kegg clinic NA 0.113 no no no up no no Betaine+blood AST+clinic 0.494324045 0 0 serum_choline clinic 0.857 0.113 no no no up no no C-peptide AST+clinic -0.420948617 0 0 DM-assocaited hormones clinic 0.228 0.113 no no no up no no Clostridium AST+clinic -0.461082297 0 0 Genus clinic 0.925 0.113 no no no up no no EPA+blood AST+clinic -0.616099071 0 0 serum_ARA clinic 0.212 0.113 no no no up no no Faecalibacterium AST+clinic 0 0 0.441228876 butyrate-producing Genus clinic 0.0039 0.113 no dn dn up no no Ferroptosis AST+clinic 0.583286279 0 0 kegg clinic NA 0.113 no no no up no no GLCA+blood AST+clinic -0.474096828 0 0 serum_bileacids clinic 0.319 0.113 no no no up no no GUDCA+blood AST+clinic 0 0 0.443076923 serum_bileacids clinic 0.0766 0.113 no no dn up no no HCA+stool AST+clinic 0 0 0.53811406 stool_bileacids clinic 0.155 0.113 no no no up no no HDCA+stool AST+clinic 0 0 -0.466967815 stool_bileacids clinic 0.176 0.113 no no no up no no iso-DCA+blood AST+clinic 0 0 -0.407692308 serum_bileacids clinic 0.38 0.113 no no no up no no Kaposi sarcoma-associated herpesvirus infection AST+clinic 0.454545455 0 0 kegg clinic NA 0.113 no no dn up no no L-2-Aminobutyric acid+blood AST+clinic 0 0 -0.413846154 yes serum_aminoacids clinic 0.000328 0.113 up up no up no no LCA+blood AST+clinic 0 0 -0.592546355 serum_bileacids clinic 0.884 0.113 no no no up no no Long-term depression AST+clinic 0.427442123 0 0 kegg clinic NA 0.113 no no no up no no Mineral absorption AST+clinic 0.500846979 0 0 kegg clinic NA 0.113 no no no up no no MIP-1b AST+clinic -0.642857143 0 0 serum_cytokines clinic 0.632 0.113 no no no up no no n3+blood AST+clinic -0.5500516 0 0 serum_fattyacid clinic 0.806 0.113 no no no up no no n6/n3+blood AST+clinic 0.560371517 0 0 serum_fattyacid clinic 0.226 0.113 no no no up no no Necroptosis AST+clinic 0.556182947 0 0 kegg clinic NA 0.113 no no no up no no Ras signaling pathway AST+clinic 0 -0.575324675 0 yes kegg clinic NA 0.113 no up up up no no Salivary secretion AST+clinic 0.494071146 0 0 kegg clinic NA 0.113 no no no up no no SFA+blood AST+clinic 0 0 -0.451538462 serum_fattyacid clinic 0.0386 0.113 up no no up no no ToFA+blood AST+clinic 0 0 -0.459230769 serum_fattyacid clinic 0.0307 0.113 up no dn up no no Toll-like receptor signaling pathway AST+clinic 0 0.436363636 0 yes kegg clinic NA 0.113 no no no up no no UFA+blood AST+clinic 0 0 -0.417692308 serum_fattyacid clinic 0.0444 0.113 up no dn up no no Wnt signaling pathway AST+clinic 0 -0.476623377 0 kegg clinic NA 0.113 no no no up no no ABC transporters Asthma 0 -0.568181818 0 kegg kegg NA NA no up up no no no Adherens junction Asthma 0 0.583003953 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Asthma 0 -0.56916996 0 kegg kegg NA NA no no no no no no African trypanosomiasis Asthma -0.451304348 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Asthma 0 -0.457509881 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Asthma 0 -0.486166008 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Asthma 0 0.470355731 0 kegg kegg NA NA no no no no no no Autophagy - animal Asthma 0 -0.506916996 0 kegg kegg NA NA no no no no no no Autophagy - other Asthma 0 -0.46541502 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Asthma 0 0.712450593 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Asthma 0 0.587944664 0.662805663 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Asthma 0 0 0.483397683 kegg kegg NA NA no no no no no no Breast cancer Asthma 0 -0.493083004 0 kegg kegg NA NA no no no no no no Butanoate metabolism Asthma 0 0.446640316 0.427541828 kegg kegg NA NA no no no no no no cAMP signaling pathway Asthma 0 0 -0.48005148 yes kegg kegg NA NA no up up no no no Carbon metabolism Asthma 0 0.686758893 0.409266409 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Asthma -0.407826087 0 0 kegg kegg NA NA no no no no no no Chagas disease Asthma 0 -0.535573123 -0.408751609 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Asthma 0 -0.441699605 0 kegg kegg NA NA no no no no no no Cholesterol metabolism Asthma 0 0.507905138 0 yes kegg kegg NA NA no no up no no no Choline metabolism in cancer Asthma 0 -0.570158103 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Asthma 0 0 -0.41029601 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Asthma 0 0.467391304 0 kegg kegg NA NA no no no no no no Clostridium Asthma 0 0.643885059 0 Genus kegg 0.925 NA no no no no no no Cysteine and methionine metabolism Asthma 0 0.435770751 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Asthma 0 0.488142292 0.592020592 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Asthma 0 0.60770751 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Asthma 0 -0.443675889 0 kegg kegg NA NA no no no no no no Fatty acid elongation Asthma 0 0.561264822 0.56988417 kegg kegg NA NA no no no no no no Focal adhesion Asthma 0 0.661067194 0 kegg kegg NA NA no up up no no no Folate biosynthesis Asthma -0.482608696 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Asthma 0 -0.505928854 0 kegg kegg NA NA no no no no no no Gap junction Asthma 0 -0.468379447 0 kegg kegg NA NA no no no no no no Gastric acid secretion Asthma 0 0.437747036 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Asthma 0 -0.664031621 0 kegg kegg NA NA no up up no no no Glycerolipid metabolism Asthma 0 -0.454545455 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Asthma 0 -0.542490119 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Asthma 0 0.661067194 0.597940798 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Asthma 0 -0.467391304 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Asthma 0 0 -0.463320463 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Asthma -0.506956522 -0.433794466 0 kegg kegg NA NA no no no no no no GnRH secretion Asthma 0 -0.507905138 0 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Asthma 0 -0.596837945 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Asthma 0.664347826 0.853754941 0.853539254 kegg kegg NA NA no no no no no no Hepatitis C Asthma -0.500869565 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Asthma 0 0.513833992 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Asthma 0 0.559288538 0 kegg kegg NA NA no no no no no no Histidine metabolism Asthma 0 0 0.404890605 kegg kegg NA NA no no no no no no Influenza A Asthma 0.523478261 0.542490119 0.481595882 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Asthma 0 -0.477272727 0 kegg kegg NA NA no no no no no no Insulin resistance Asthma -0.46 -0.447628458 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Asthma 0.664347826 0.790513834 0.827027027 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Asthma 0 -0.550395257 0 kegg kegg NA NA no no no no no no Leishmaniasis Asthma 0 0.423913043 0.466666667 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Asthma 0 0.583003953 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Asthma 0 -0.677865613 0 kegg kegg NA NA no no no no no no Malaria Asthma 0.493913043 -0.652173913 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Asthma -0.477391304 0 0 kegg kegg NA NA no no no no no no Measles Asthma -0.6 0 0 kegg kegg NA NA no no no no no no Melanoma Asthma 0 -0.5 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Asthma 0 0.575098814 0.56962677 kegg kegg NA NA no no no no no no MicroRNAs in cancer Asthma 0 -0.43083004 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Asthma 0 -0.434782609 0 kegg kegg NA NA no no no no no no Nicotine addiction Asthma 0 -0.456521739 0 kegg kegg NA NA no up up no no no Nitrogen metabolism Asthma 0 -0.429841897 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Asthma 0 0.514822134 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Asthma 0 -0.609683794 0 kegg kegg NA NA no no no no no no Notch signaling pathway Asthma 0 -0.419960474 0 kegg kegg NA NA no no no no no no Oocyte meiosis Asthma 0 0.453557312 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Asthma -0.453913043 -0.422924901 0 kegg kegg NA NA no no no no no no p53 signaling pathway Asthma 0 -0.618577075 0 kegg kegg NA NA no no no no no no Pathways in cancer Asthma 0 -0.633399209 -0.407979408 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Asthma -0.437391304 -0.471343874 -0.422908623 kegg kegg NA NA no no no no no no Phenylalanine metabolism Asthma 0 0.442687747 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Asthma 0 -0.574110672 -0.426254826 kegg kegg NA NA no up up no no no Phototransduction Asthma 0 0.592885375 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Asthma -0.529565217 0 0 yes kegg kegg NA NA no up up no no no Platelet activation Asthma 0 0.499011858 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Asthma 0 0.508893281 0.500900901 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Asthma -0.451304348 -0.477272727 0 kegg kegg NA NA no no no no no no Propanoate metabolism Asthma 0 0.454545455 0 kegg kegg NA NA no no no no no no Prostate cancer Asthma 0 0 -0.405148005 kegg kegg NA NA no no no no no no Proteasome Asthma 0 0.622529644 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Asthma 0.447826087 0 0 yes kegg kegg NA NA no up up no no no Protein export Asthma 0 0.419960474 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Asthma 0 0.435770751 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Asthma 0 0.602766798 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Asthma 0 -0.463438735 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Asthma 0 -0.41798419 0 kegg kegg NA NA no no no no no no Salmonella infection Asthma 0 0 0.404375804 kegg kegg NA NA no no no no no no Small cell lung cancer Asthma 0 0 -0.466924067 kegg kegg NA NA no no up no no no Sphingolipid metabolism Asthma 0 0.515810277 0 kegg kegg NA NA no no no no no no Spliceosome Asthma 0 -0.434782609 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Asthma 0.493043478 0.496047431 0.51994852 kegg kegg NA NA up no no no no no Steroid hormone biosynthesis Asthma 0 0.42687747 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Asthma -0.630434783 0 0 kegg kegg NA NA no no no no no no Taste transduction Asthma -0.545217391 0 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Asthma 0 -0.568181818 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Asthma 0 0.455533597 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Asthma 0.532173913 0 0.658172458 kegg kegg NA NA no no no no no no Th17 cell differentiation Asthma 0.504347826 0 0.694723295 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Asthma 0 0.42687747 0 kegg kegg NA NA no no no no no no Tight junction Asthma 0 0.604743083 0 kegg kegg NA NA no no no no no no Toxoplasmosis Asthma 0.56 0.45256917 0.841441441 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Asthma 0 -0.486166008 -0.425225225 kegg kegg NA NA no no no no no no Tryptophan metabolism Asthma 0 0.58201581 0 kegg kegg NA NA no up no no no no Tuberculosis Asthma 0.453913043 0 0.538996139 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Asthma 0.448695652 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Asthma 0 0.468379447 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Autoimmune thyroid disease 0.462608696 0 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Autoimmune thyroid disease 0 -0.43972332 0 kegg kegg NA NA no no up no no no Aldosterone synthesis and secretion Autoimmune thyroid disease 0 -0.612648221 0 kegg kegg NA NA no up up no no no Alzheimer disease Autoimmune thyroid disease -0.507826087 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Autoimmune thyroid disease 0 0 -0.411840412 kegg kegg NA NA no no no no no no Amphetamine addiction Autoimmune thyroid disease -0.426086957 -0.684782609 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Autoimmune thyroid disease 0 -0.665019763 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Autoimmune thyroid disease -0.455652174 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Autoimmune thyroid disease 0 0 -0.455598456 kegg kegg NA NA no no no no no no Antigen processing and presentation Autoimmune thyroid disease 0.469565217 0.533596838 0.645817246 kegg kegg NA NA no no no no no no Apelin signaling pathway Autoimmune thyroid disease -0.459130435 0 0 kegg kegg NA NA no no no no no no Apoptosis Autoimmune thyroid disease 0 0.710474308 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Autoimmune thyroid disease 0 0 -0.555469755 kegg kegg NA NA no no no no no no Asthma Autoimmune thyroid disease 0.448695652 0 0 kegg kegg NA NA no no no no no no Autophagy - other Autoimmune thyroid disease -0.580869565 0 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Autoimmune thyroid disease 0 0.472332016 0 kegg kegg NA NA no no no no no no Bacteroides Autoimmune thyroid disease 0.433043478 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Autoimmune thyroid disease -0.592173913 -0.584980237 -0.535649936 kegg kegg NA NA no no no no no no Base excision repair Autoimmune thyroid disease 0 -0.530632411 -0.436550837 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Autoimmune thyroid disease 0.570434783 0.587944664 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Autoimmune thyroid disease 0 -0.843873518 0 kegg kegg NA NA no no no no no no Butyricicoccus Autoimmune thyroid disease 0 0 0.471212756 butyrate-producing Genus kegg 0.852 NA no no no no no no C-type lectin receptor signaling pathway Autoimmune thyroid disease 0 0.523715415 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Autoimmune thyroid disease -0.452173913 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Autoimmune thyroid disease 0.477391304 0.475296443 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Autoimmune thyroid disease -0.428695652 0 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Autoimmune thyroid disease 0.957391304 0.960474308 0.942599743 kegg kegg NA NA no no no no no no Cell cycle Autoimmune thyroid disease -0.607826087 -0.612648221 0 kegg kegg NA NA no no no no no no Cellular senescence Autoimmune thyroid disease 0.830434783 0.935770751 0.886486486 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Autoimmune thyroid disease 0 0 -0.444530245 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Autoimmune thyroid disease 0 0.528656126 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Autoimmune thyroid disease -0.535652174 -0.588932806 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Autoimmune thyroid disease 0 0.451581028 0.466666667 kegg kegg NA NA no no no no no no Cholesterol metabolism Autoimmune thyroid disease 0 0.708498024 0 yes kegg kegg NA NA no no up no no no Circadian rhythm Autoimmune thyroid disease -0.499130435 -0.504940711 0 kegg kegg NA NA no no no no no no Cocaine addiction Autoimmune thyroid disease 0 -0.522727273 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Autoimmune thyroid disease 0.528695652 0.57312253 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Autoimmune thyroid disease 0 -0.627470356 0 kegg kegg NA NA no no up no no no Cushing syndrome Autoimmune thyroid disease 0 -0.698616601 0 kegg kegg NA NA no no up no no no Cytosolic DNA-sensing pathway Autoimmune thyroid disease 0 0 0.47979408 kegg kegg NA NA no no no no no no DNA replication Autoimmune thyroid disease 0 -0.418972332 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Autoimmune thyroid disease -0.44 -0.524703557 0 kegg kegg NA NA no up no no no no Endocrine and other factor-regulated calcium reabsorption Autoimmune thyroid disease 0 -0.468379447 0 kegg kegg NA NA no no no no no no Endocrine resistance Autoimmune thyroid disease 0 -0.563241107 0 kegg kegg NA NA no no no no no no Endocytosis Autoimmune thyroid disease 0.833043478 0.944664032 0.909137709 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Autoimmune thyroid disease 0 0.577075099 0.542084942 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Autoimmune thyroid disease 0.475652174 0.544466403 0.736422136 kegg kegg NA NA no no no no no no Estrogen signaling pathway Autoimmune thyroid disease -0.426956522 -0.490118577 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Autoimmune thyroid disease -0.502608696 -0.698616601 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Autoimmune thyroid disease 0 -0.563241107 -0.463320463 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Autoimmune thyroid disease 0 0.576086957 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Autoimmune thyroid disease 0 0.546442688 0 kegg kegg NA NA no no no no no no Folate biosynthesis Autoimmune thyroid disease -0.459130435 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Autoimmune thyroid disease 0 0 -0.534877735 kegg kegg NA NA no no no no no no Glucagon signaling pathway Autoimmune thyroid disease 0 -0.62944664 0 kegg kegg NA NA no no no no no no Glutathione metabolism Autoimmune thyroid disease 0 -0.540513834 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Autoimmune thyroid disease -0.487826087 -0.472332016 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Autoimmune thyroid disease 0 -0.780632411 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Autoimmune thyroid disease 0.424347826 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Autoimmune thyroid disease 0 0.624505929 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Autoimmune thyroid disease 0 -0.752964427 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Autoimmune thyroid disease 0 -0.553359684 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Autoimmune thyroid disease 0 -0.446640316 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Autoimmune thyroid disease 0 0.53458498 0.68957529 kegg kegg NA NA no no no no no no Homologous recombination Autoimmune thyroid disease 0 -0.505928854 -0.532818533 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Autoimmune thyroid disease 0.42173913 0.535573123 0.682625483 kegg kegg NA NA no no dn no no no Human immunodeficiency virus 1 infection Autoimmune thyroid disease 0 0.53458498 0.665894466 kegg kegg NA NA no no no no no no Human papillomavirus infection Autoimmune thyroid disease 0.839130435 0.90513834 0.841698842 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Autoimmune thyroid disease 0.471304348 0.519762846 0.714543115 kegg kegg NA NA no no no no no no Huntington disease Autoimmune thyroid disease -0.474782609 0 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Autoimmune thyroid disease 0 0.563241107 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Autoimmune thyroid disease 0 -0.421936759 0 kegg kegg NA NA no no no no no no Influenza A Autoimmune thyroid disease 0.605217391 0.770750988 0.544401544 kegg kegg NA NA no no no no no no Insulin resistance Autoimmune thyroid disease -0.462608696 0 0 kegg kegg NA NA no no no no no no Insulin secretion Autoimmune thyroid disease 0 -0.570158103 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Autoimmune thyroid disease -0.450434783 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Autoimmune thyroid disease 0.511304348 0.506916996 0.413127413 kegg kegg NA NA no no no no no no Long-term potentiation Autoimmune thyroid disease -0.473913043 0 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Autoimmune thyroid disease 0 -0.471343874 0 kegg kegg NA NA no no no no no no Lysosome Autoimmune thyroid disease 0 0.704545455 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Autoimmune thyroid disease -0.595652174 0 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Autoimmune thyroid disease 0 -0.513833992 0 kegg kegg NA NA no up no no no no Measles Autoimmune thyroid disease -0.502608696 0 0 kegg kegg NA NA no no no no no no Mismatch repair Autoimmune thyroid disease 0 -0.545454545 0 kegg kegg NA NA no no no no no no Mitophagy - animal Autoimmune thyroid disease 0 -0.491106719 0 kegg kegg NA NA no no no no no no Morphine addiction Autoimmune thyroid disease 0 -0.428853755 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Autoimmune thyroid disease -0.593043478 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Autoimmune thyroid disease 0.822608696 0.95256917 0.8998713 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Autoimmune thyroid disease 0 0.615612648 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Autoimmune thyroid disease 0 0.492094862 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Autoimmune thyroid disease 0.406086957 0.612648221 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Autoimmune thyroid disease 0 0.490118577 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Autoimmune thyroid disease -0.504347826 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Autoimmune thyroid disease 0 -0.589920949 -0.535907336 kegg kegg NA NA no no no no no no One carbon pool by folate Autoimmune thyroid disease 0 -0.546442688 0 kegg kegg NA NA no no no no no no Oocyte meiosis Autoimmune thyroid disease -0.542608696 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Autoimmune thyroid disease 0 0.588932806 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Autoimmune thyroid disease -0.529565217 -0.53458498 -0.400514801 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Autoimmune thyroid disease 0 -0.457509881 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Autoimmune thyroid disease -0.460869565 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Autoimmune thyroid disease -0.511304348 -0.491106719 -0.543886744 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Autoimmune thyroid disease -0.406086957 -0.434782609 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Autoimmune thyroid disease 0 0.7756917 0.474646075 kegg kegg NA NA no no no no no no Pathways in cancer Autoimmune thyroid disease -0.551304348 0 -0.441698842 kegg kegg NA NA no no no no no no Pentose phosphate pathway Autoimmune thyroid disease 0.453043478 0.663043478 0 kegg kegg NA NA no no no no no no Pertussis Autoimmune thyroid disease 0 0.649209486 0 kegg kegg NA NA no no dn no no no Phagosome Autoimmune thyroid disease 0.895652174 0.916007905 0.814929215 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Autoimmune thyroid disease -0.53826087 0 0 yes kegg kegg NA NA no up up no no no Platinum drug resistance Autoimmune thyroid disease 0 0 -0.578635779 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Autoimmune thyroid disease 0 -0.745059289 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Autoimmune thyroid disease 0 0.457509881 0 kegg kegg NA NA no no no no no no Prion disease Autoimmune thyroid disease -0.459130435 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Autoimmune thyroid disease -0.429565217 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Autoimmune thyroid disease 0 0.455533597 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Autoimmune thyroid disease 0.426086957 0.456521739 0 yes kegg kegg NA NA no up up no no no Protein export Autoimmune thyroid disease -0.557391304 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Autoimmune thyroid disease 0 -0.471343874 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Autoimmune thyroid disease 0 0 -0.402831403 kegg kegg NA NA no no no no no no Purine metabolism Autoimmune thyroid disease 0 -0.751976285 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Autoimmune thyroid disease 0 -0.423913043 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Autoimmune thyroid disease 0 -0.431818182 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Autoimmune thyroid disease 0 0.677865613 0 kegg kegg NA NA no no no no no no Retinol metabolism Autoimmune thyroid disease 0 -0.414031621 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Autoimmune thyroid disease -0.517391304 0 0 kegg kegg NA NA no no up no no no Ribosome biogenesis in eukaryotes Autoimmune thyroid disease -0.432173913 -0.536561265 0 kegg kegg NA NA no no no no no no RNA degradation Autoimmune thyroid disease -0.503478261 0 0 kegg kegg NA NA no no no no no no RNA polymerase Autoimmune thyroid disease -0.46173913 -0.570158103 0 kegg kegg NA NA no no no no no no Ruminococcus Autoimmune thyroid disease 0 0 0.405662806 acetate-producing Genus kegg 0.335 NA no no no no no no Salmonella infection Autoimmune thyroid disease 0 0.706521739 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Autoimmune thyroid disease -0.53826087 -0.531620553 -0.468725869 kegg kegg NA NA no no no no no no Sphingolipid metabolism Autoimmune thyroid disease 0 0.445652174 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Autoimmune thyroid disease 0 0.713438735 0 kegg kegg NA NA no no no no no no Spliceosome Autoimmune thyroid disease -0.415652174 0 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Autoimmune thyroid disease 0.569565217 0.731225296 0 kegg kegg NA NA up no no no no no Steroid biosynthesis Autoimmune thyroid disease -0.605217391 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Autoimmune thyroid disease 0 0.462450593 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Autoimmune thyroid disease 0 -0.589920949 -0.425740026 kegg kegg NA NA no no no no no no Taste transduction Autoimmune thyroid disease -0.659130435 -0.586956522 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Autoimmune thyroid disease -0.414782609 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Autoimmune thyroid disease -0.695652174 0 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Autoimmune thyroid disease 0 0.570158103 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Autoimmune thyroid disease 0 0.540513834 0 kegg kegg NA NA no no no no no no Thermogenesis Autoimmune thyroid disease -0.436521739 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Autoimmune thyroid disease 0 -0.592885375 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Autoimmune thyroid disease 0 -0.496047431 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Autoimmune thyroid disease 0 0.48715415 0.462548263 yes kegg kegg NA NA no no no no no no Toxoplasmosis Autoimmune thyroid disease 0 0.563241107 0 kegg kegg NA NA no no no no no no Tuberculosis Autoimmune thyroid disease 0.476521739 0.698616601 0 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Autoimmune thyroid disease 1 0.999011858 0.999485199 kegg kegg NA NA no no no no no no Tyrosine metabolism Autoimmune thyroid disease 0 -0.449604743 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Autoimmune thyroid disease 0 -0.449604743 -0.424967825 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Autoimmune thyroid disease 0 -0.555335968 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Autoimmune thyroid disease 0 -0.425889328 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Autoimmune thyroid disease 0.803478261 0.916996047 0.856370656 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Autoimmune thyroid disease -0.532173913 0 0 kegg kegg NA NA no no no no no no Yersinia infection Autoimmune thyroid disease 0 0.713438735 0.407207207 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Autophagy - animal -0.553043478 -0.628458498 0 kegg kegg NA NA no no no no no no ABC transporters Autophagy - animal 0 0.485177866 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" Autophagy - animal 0.58173913 0.836956522 0 kegg kegg NA NA no no no no no no Alistipes Autophagy - animal -0.523149093 0 0 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism Autophagy - animal 0 0.473320158 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Autophagy - animal -0.509565217 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Autophagy - animal 0 0.77173913 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Autophagy - animal 0.490434783 0.7756917 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Autophagy - animal 0 -0.463438735 0 kegg kegg NA NA no no no no no no Autophagy - other Autophagy - animal 0.756521739 0.656126482 0.512226512 kegg kegg NA NA no no no no no no beta-Alanine metabolism Autophagy - animal -0.430434783 -0.505928854 0 kegg kegg NA NA no no no no no no Bifidobacterium Autophagy - animal 0 -0.473503186 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Biosynthesis of amino acids Autophagy - animal 0 0.442687747 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Autophagy - animal -0.589565217 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Autophagy - animal -0.446956522 -0.746047431 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Autophagy - animal 0 0.438735178 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Autophagy - animal -0.411304348 0 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Autophagy - animal 0.625217391 0.520750988 0.408236808 kegg kegg NA NA no no no no no no Chemokine signaling pathway Autophagy - animal 0 0.460474308 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Autophagy - animal 0 -0.744071146 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Autophagy - animal 0 -0.703557312 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Autophagy - animal 0 0 -0.477220077 kegg kegg NA NA no no no no no no DNA replication Autophagy - animal 0 -0.670948617 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Autophagy - animal 0 -0.831027668 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Autophagy - animal 0 -0.880434783 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Autophagy - animal 0 -0.529644269 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Autophagy - animal 0.546956522 0.668972332 0.650965251 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Autophagy - animal 0.543478261 0.774703557 0.498069498 kegg kegg NA NA no no no no no no Fatty acid degradation Autophagy - animal 0 0.598814229 0 kegg kegg NA NA no no no no no no Fatty acid elongation Autophagy - animal -0.473043478 -0.501976285 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Autophagy - animal 0 0.497035573 0 kegg kegg NA NA no no no no no no Folate biosynthesis Autophagy - animal 0 -0.449604743 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Autophagy - animal 0.697391304 0.749011858 0.430630631 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Autophagy - animal 0 0.497035573 0 kegg kegg NA NA no no no no no no Galactose metabolism Autophagy - animal 0 0.500988142 0 kegg kegg NA NA no no no no no no Glutathione metabolism Autophagy - animal -0.527826087 -0.589920949 -0.467953668 kegg kegg NA NA no no no no no no Glycerolipid metabolism Autophagy - animal 0 0.572134387 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Autophagy - animal 0.484347826 0.52173913 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Autophagy - animal -0.592173913 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Autophagy - animal 0 -0.735177866 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Autophagy - animal 0.474782609 0.863636364 0.406692407 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Autophagy - animal -0.599130435 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Autophagy - animal 0 0.777667984 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Autophagy - animal 0 -0.586956522 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Autophagy - animal 0 0.515810277 0 kegg kegg NA NA no no no no no no Lachnospira Autophagy - animal 0 -0.551519661 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Linoleic acid metabolism Autophagy - animal 0 -0.443675889 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Autophagy - animal 0.534782609 0.497035573 0.581467181 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Autophagy - animal 0 -0.846837945 0 kegg kegg NA NA no no no no no no Mismatch repair Autophagy - animal 0 -0.56027668 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Autophagy - animal 0 0.423913043 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Autophagy - animal 0 -0.670948617 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Autophagy - animal 0.58173913 0.93083004 0.465637066 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Autophagy - animal 0.524347826 0.752964427 0.408494208 kegg kegg NA NA no no no no no no Nitrogen metabolism Autophagy - animal 0 0.749011858 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Autophagy - animal -0.412173913 -0.558300395 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Autophagy - animal 0 -0.538537549 0 kegg kegg NA NA no no no no no no One carbon pool by folate Autophagy - animal 0 -0.588932806 0 kegg kegg NA NA no no no no no no Oocyte meiosis Autophagy - animal 0 -0.645256917 0 kegg kegg NA NA no no no no no no Oscillospira Autophagy - animal 0 0.441699605 0 LPS-producing Genus kegg 0.62 NA no no no no no no Other glycan degradation Autophagy - animal 0 0.482213439 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Autophagy - animal 0 -0.721343874 -0.492921493 kegg kegg NA NA no no no no no no p53 signaling pathway Autophagy - animal 0.633043478 0.445652174 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Autophagy - animal 0.460869565 0.639328063 0.45019305 kegg kegg NA NA no no dn no no no Paraprevotella Autophagy - animal -0.410684451 0 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Autophagy - animal -0.516521739 -0.740118577 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Autophagy - animal -0.737391304 -0.767786561 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Autophagy - animal 0 0.720355731 0 kegg kegg NA NA no up up no no no Platinum drug resistance Autophagy - animal 0.577391304 0.415019763 0.454311454 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Autophagy - animal -0.527826087 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Autophagy - animal 0 0.729249012 0 kegg kegg NA NA no no no no no no Prevotella Autophagy - animal 0 0.467631712 0 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Autophagy - animal 0 -0.506916996 0 kegg kegg NA NA no no no no no no Propanoate metabolism Autophagy - animal 0 -0.671936759 0 kegg kegg NA NA no no no no no no Proteasome Autophagy - animal 0 -0.701581028 0 kegg kegg NA NA no no no no no no Protein export Autophagy - animal 0 -0.711462451 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Autophagy - animal 0 -0.646245059 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Autophagy - animal 0 -0.733201581 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Autophagy - animal -0.527826087 -0.622529644 -0.461261261 kegg kegg NA NA no no no no no no Ras signaling pathway Autophagy - animal 0 -0.684782609 0 yes kegg kegg NA NA no up up no no no Retinol metabolism Autophagy - animal 0 -0.479249012 0 kegg kegg NA NA no no no no no no Ribosome Autophagy - animal 0 -0.660079051 -0.426512227 kegg kegg NA NA no no no no no no RNA degradation Autophagy - animal 0 -0.59486166 0 kegg kegg NA NA no no no no no no RNA polymerase Autophagy - animal 0 -0.486166008 0 kegg kegg NA NA no no no no no no RNA transport Autophagy - animal 0 -0.46541502 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Autophagy - animal 0.525217391 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Autophagy - animal 0 0.679841897 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Autophagy - animal 0.58173913 0.449604743 0.46023166 kegg kegg NA NA no no no no no no Spliceosome Autophagy - animal 0.499130435 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Autophagy - animal 0 0.661067194 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Autophagy - animal 0 -0.524703557 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Autophagy - animal 0 -0.563241107 0 kegg kegg NA NA no no no no no no Sulfur metabolism Autophagy - animal -0.495652174 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Autophagy - animal 0 -0.453557312 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Autophagy - animal 0.488695652 0.646245059 0 kegg kegg NA NA no no no no no no Thiamine metabolism Autophagy - animal 0 -0.535573123 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Autophagy - animal 0 -0.614624506 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Autophagy - animal -0.506086957 -0.733201581 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Autophagy - animal 0 -0.550395257 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Autophagy - animal 0 -0.457509881 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Autophagy - animal 0 -0.672924901 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Autophagy - animal 0 -0.484189723 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Autophagy - animal 0 0 -0.587902188 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Autophagy - other -0.424347826 0 0 kegg kegg NA NA no no no no no no ABC transporters Autophagy - other 0 0.638339921 0 kegg kegg NA NA no up up no no no Arachidonic acid metabolism Autophagy - other 0 -0.523715415 -0.710682111 kegg kegg NA NA no no no no no no Basal transcription factors Autophagy - other 0.744347826 0 0.671042471 kegg kegg NA NA no no no no no no Base excision repair Autophagy - other 0.543478261 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Autophagy - other -0.51826087 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Autophagy - other -0.471304348 0 -0.562676963 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Autophagy - other -0.433913043 0 -0.446846847 kegg kegg NA NA no no no no no no Calcium signaling pathway Autophagy - other 0 0 0.411068211 kegg kegg NA NA no up up no no no cAMP signaling pathway Autophagy - other 0.467826087 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Autophagy - other -0.47826087 -0.493083004 -0.44967825 kegg kegg NA NA no no no no no no Cell cycle Autophagy - other 0.497391304 0 0.625225225 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Autophagy - other 0 -0.431818182 -0.432432432 kegg kegg NA NA no no no no no no DNA replication Autophagy - other 0 0 0.44041184 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Autophagy - other 0 -0.43972332 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Autophagy - other 0.554782609 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Autophagy - other 0.466956522 0.559288538 0.693436293 kegg kegg NA NA no no no no no no Fanconi anemia pathway Autophagy - other 0 0 0.522522523 kegg kegg NA NA no no no no no no Fatty acid elongation Autophagy - other -0.429565217 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Autophagy - other 0.408695652 0.579051383 0 kegg kegg NA NA no no no no no no Galactose metabolism Autophagy - other -0.473913043 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Autophagy - other 0 0 -0.648906049 kegg kegg NA NA no no no no no no Glycerolipid metabolism Autophagy - other 0 0.586956522 0.495752896 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Autophagy - other 0.432173913 0.651185771 0.579150579 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Autophagy - other -0.416521739 0 -0.451480051 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Autophagy - other 0 -0.482213439 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Autophagy - other 0 0.432806324 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Autophagy - other -0.526086957 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Autophagy - other 0 0 0.514543115 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Autophagy - other 0 0 0.401287001 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Autophagy - other 0.572173913 0 0 kegg kegg NA NA no no no no no no Homologous recombination Autophagy - other 0 0.599802372 0.457142857 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Autophagy - other 0 0.657114625 0.451737452 kegg kegg NA NA no no no no no no Lysine degradation Autophagy - other 0.572173913 0.683794466 0.726383526 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Autophagy - other 0 0.611660079 0.659202059 kegg kegg NA NA no no no no no no MAPK signaling pathway Autophagy - other 0 0.545454545 0.521750322 kegg kegg NA NA no no no no no no mRNA surveillance pathway Autophagy - other 0.652173913 0 0.727155727 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Autophagy - other 0 0.75 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Autophagy - other 0 0 0.555212355 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Autophagy - other 0 0.558300395 0 kegg kegg NA NA no no no no no no Oocyte meiosis Autophagy - other 0.511304348 0 0.515057915 kegg kegg NA NA no no no no no no Other glycan degradation Autophagy - other 0 0.674901186 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Autophagy - other 0.584347826 0.618577075 0.673359073 kegg kegg NA NA no no no no no no p53 signaling pathway Autophagy - other 0.70173913 0.668972332 0.453796654 kegg kegg NA NA no no no no no no Pentose phosphate pathway Autophagy - other -0.428695652 0 -0.485456885 kegg kegg NA NA no no no no no no Phenylalanine metabolism Autophagy - other -0.667826087 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Autophagy - other 0.49826087 0 0.687773488 kegg kegg NA NA no no no no no no Platinum drug resistance Autophagy - other 0.595652174 0.714426877 0.513256113 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Autophagy - other -0.407826087 0 -0.466924067 kegg kegg NA NA no no no no no no Proteasome Autophagy - other 0.49826087 0 0 kegg kegg NA NA no no no no no no Protein export Autophagy - other 0.68 0 0.52998713 kegg kegg NA NA no no no no no no Rap1 signaling pathway Autophagy - other -0.734782609 -0.805335968 -0.55032175 kegg kegg NA NA no no no no no no Ras signaling pathway Autophagy - other 0 0 0.553667954 yes kegg kegg NA NA no up up no no no Ribosome Autophagy - other 0.453913043 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Autophagy - other 0.570434783 0 0.611068211 kegg kegg NA NA no no no no no no RNA degradation Autophagy - other 0.633043478 0 0.736422136 kegg kegg NA NA no no no no no no RNA polymerase Autophagy - other 0.667826087 0 0.405662806 kegg kegg NA NA no no no no no no RNA transport Autophagy - other 0.42173913 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Autophagy - other 0.644347826 0.548418972 0.494465894 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Autophagy - other 0 0.747035573 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Autophagy - other 0.433043478 0 0.427284427 kegg kegg NA NA no no no no no no Spliceosome Autophagy - other 0.766086957 0.807312253 0.761132561 kegg kegg NA NA no no no no no no Sulfur metabolism Autophagy - other -0.544347826 0 -0.527670528 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Autophagy - other 0 0.590909091 0.438610039 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Autophagy - other 0.54173913 0 0.543886744 kegg kegg NA NA no no no no no no Tyrosine metabolism Autophagy - other -0.422608696 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Autophagy - other 0.566956522 0 0.609009009 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Autophagy - other 0 -0.553359684 -0.438095238 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Axon guidance -0.556521739 0 0 kegg kegg NA NA no no no no up up ABC transporters Axon guidance -0.44173913 -0.508893281 0 kegg kegg NA NA no up up no up up Adrenergic signaling in cardiomyocytes Axon guidance 0.6 0 0 kegg kegg NA NA no no up no up up alpha-Linolenic acid metabolism Axon guidance -0.584347826 -0.491106719 0 kegg kegg NA NA no no no no up up Amino sugar and nucleotide sugar metabolism Axon guidance -0.710434783 -0.64229249 -0.476705277 kegg kegg NA NA no no no no up up Aminoacyl-tRNA biosynthesis Axon guidance -0.580869565 -0.526679842 0 kegg kegg NA NA no no no no up up Antifolate resistance Axon guidance -0.585217391 -0.450592885 0 kegg kegg NA NA no no no no up up Apoptosis - multiple species Axon guidance 0 -0.507905138 0 kegg kegg NA NA no no no no up up Arachidonic acid metabolism Axon guidance -0.466086957 0 -0.507850708 kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism Axon guidance -0.492173913 0 0 kegg kegg NA NA no no no no up up Autophagy - animal Axon guidance 0 0 0.412355212 kegg kegg NA NA no no no no up up Autophagy - other Axon guidance 0.41826087 0 0.507850708 kegg kegg NA NA no no no no up up beta-Alanine metabolism Axon guidance -0.723478261 0 0 kegg kegg NA NA no no no no up up Biosynthesis of amino acids Axon guidance -0.411304348 0 0 kegg kegg NA NA no no no no up up Biosynthesis of cofactors Axon guidance -0.471304348 -0.41798419 -0.494723295 kegg kegg NA NA no no no no up up Biosynthesis of unsaturated fatty acids Axon guidance -0.488695652 0 0 kegg kegg NA NA no no no no up up Butanoate metabolism Axon guidance -0.56 0 0 kegg kegg NA NA no no no no up up Calcium signaling pathway Axon guidance 0.683478261 0 0 kegg kegg NA NA no up up no up up cAMP signaling pathway Axon guidance 0.654782609 0 0 yes kegg kegg NA NA no up up no up up Carbon metabolism Axon guidance -0.508695652 0 0 kegg kegg NA NA no no no no up up Cardiac muscle contraction Axon guidance 0.54173913 0 0 kegg kegg NA NA no no up no up up cGMP-PKG signaling pathway Axon guidance 0 0 0.526898327 kegg kegg NA NA no no no no up up Chemokine signaling pathway Axon guidance 0.54173913 0 0 kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) Axon guidance -0.476521739 0 0 kegg kegg NA NA no no no no up up Drug metabolism - other enzymes Axon guidance -0.524347826 0 0 kegg kegg NA NA no no no no up up Endocytosis Axon guidance 0 0.42687747 0 kegg kegg NA NA no no no no up up ErbB signaling pathway Axon guidance 0.485217391 0 0.420849421 kegg kegg NA NA no no no no up up Fanconi anemia pathway Axon guidance 0 -0.578063241 0 kegg kegg NA NA no no no no up up Fatty acid degradation Axon guidance -0.460869565 0 0 kegg kegg NA NA no no no no up up Fatty acid elongation Axon guidance -0.440869565 0 0 kegg kegg NA NA no no no no up up Fatty acid metabolism Axon guidance -0.48173913 0 0 kegg kegg NA NA no no no no up up Fructose and mannose metabolism Axon guidance -0.690434783 0 0 kegg kegg NA NA no no no no up up Galactose metabolism Axon guidance -0.709565217 0 0 kegg kegg NA NA no no no no up up Glutathione metabolism Axon guidance 0 0 -0.517374517 kegg kegg NA NA no no no no up up Glycerolipid metabolism Axon guidance 0 -0.443675889 0 kegg kegg NA NA no no up no up up Glycerophospholipid metabolism Axon guidance 0 -0.550395257 0 kegg kegg NA NA no no up no up up "Glycine, serine and threonine metabolism" Axon guidance 0 0 -0.433976834 kegg kegg NA NA no up no no up up Glycolysis / Gluconeogenesis Axon guidance -0.562608696 0 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate Axon guidance 0.454782609 0 0 kegg kegg NA NA no no no no up up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Axon guidance 0 -0.661067194 0 kegg kegg NA NA no no no no up up Hedgehog signaling pathway Axon guidance 0 -0.434782609 0 kegg kegg NA NA no no no no up up Histidine metabolism Axon guidance -0.746086957 -0.468379447 0 kegg kegg NA NA no no no no up up Homologous recombination Axon guidance 0 -0.62055336 0 kegg kegg NA NA no no no no up up Inositol phosphate metabolism Axon guidance 0 -0.418972332 0 kegg kegg NA NA no no no no up up Lysosome Axon guidance 0 0.453557312 0 kegg kegg NA NA no no no no up up Mannose type O-glycan biosynthesis Axon guidance 0.473913043 0 0 kegg kegg NA NA no no no no up up mRNA surveillance pathway Axon guidance 0.452173913 0 0 kegg kegg NA NA no no no no up up Non-homologous end-joining Axon guidance -0.514782609 0 0 kegg kegg NA NA no no no no up up Nucleotide excision repair Axon guidance 0 -0.418972332 0 kegg kegg NA NA no no no no up up One carbon pool by folate Axon guidance -0.431304348 -0.46541502 0 kegg kegg NA NA no no no no up up Oocyte meiosis Axon guidance 0 0 0.422908623 kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis Axon guidance 0 -0.420948617 0 kegg kegg NA NA no no no no up up Oxidative phosphorylation Axon guidance 0.500869565 0 0 kegg kegg NA NA no no no no up up p53 signaling pathway Axon guidance 0 -0.557312253 0 kegg kegg NA NA no no no no up up Phenylalanine metabolism Axon guidance -0.550434783 0 0 kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system Axon guidance 0.535652174 0 0 kegg kegg NA NA no no no no up up Porphyrin and chlorophyll metabolism Axon guidance 0 0 -0.47001287 kegg kegg NA NA no no no no up up PPAR signaling pathway Axon guidance 0 0 0.404890605 kegg kegg NA NA no no no no up up Primary bile acid biosynthesis Axon guidance -0.526956522 0 0 kegg kegg NA NA no no no no up up Pyrimidine metabolism Axon guidance -0.659130435 0 0 kegg kegg NA NA no no no no up up Pyruvate metabolism Axon guidance -0.495652174 0 0 kegg kegg NA NA no no no no up up Ras signaling pathway Axon guidance 0.763478261 0 0 yes kegg kegg NA NA no up up no up up Retinol metabolism Axon guidance -0.553913043 -0.545454545 0 kegg kegg NA NA no no no no up up RNA degradation Axon guidance 0.5 0 0 kegg kegg NA NA no no no no up up Selenocompound metabolism Axon guidance 0 -0.51284585 0 kegg kegg NA NA no no no no up up Sphingolipid signaling pathway Axon guidance 0.653913043 0.727272727 0.463577864 kegg kegg NA NA no no no no up up Starch and sucrose metabolism Axon guidance -0.446086957 0 0 kegg kegg NA NA no no no no up up Steroid hormone biosynthesis Axon guidance -0.523478261 -0.45256917 0 kegg kegg NA NA no no no no up up Sulfur metabolism Axon guidance -0.410434783 0 0 kegg kegg NA NA no no no no up up Synthesis and degradation of ketone bodies Axon guidance -0.423478261 0 0 kegg kegg NA NA no no no no up up TGF-beta signaling pathway Axon guidance 0.569565217 0 0 kegg kegg NA NA no no no no up up Tryptophan metabolism Axon guidance -0.660869565 0 0 kegg kegg NA NA no up no no up up Tyrosine metabolism Axon guidance -0.654782609 0 0 kegg kegg NA NA no no no no up up Ubiquinone and other terpenoid-quinone biosynthesis Axon guidance -0.64173913 -0.447628458 0 kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" Axon guidance -0.597391304 0 0 kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Axon guidance 0.476521739 0 0 kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor Axon guidance 0.613043478 0 0 kegg kegg NA NA no no no no up up Wnt signaling pathway Axon guidance 0.537391304 0 0 kegg kegg NA NA no no no no up up 2-Oxocarboxylic acid metabolism B cell receptor signaling pathway 0 -0.533596838 0 kegg kegg NA NA no no no no no no Adherens junction B cell receptor signaling pathway 0 -0.458498024 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes B cell receptor signaling pathway 0 -0.541501976 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" B cell receptor signaling pathway 0 0.653162055 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis B cell receptor signaling pathway 0 -0.510869565 -0.406692407 kegg kegg NA NA no no no no no no AMPK signaling pathway B cell receptor signaling pathway -0.453043478 -0.420948617 0 kegg kegg NA NA no no no no no no Anaerostipes B cell receptor signaling pathway 0 0 -0.425649417 butyrate-producing Genus kegg 0.568 NA no no no no no no Antifolate resistance B cell receptor signaling pathway 0 -0.481225296 0 kegg kegg NA NA no no no no no no Apelin signaling pathway B cell receptor signaling pathway 0 -0.67687747 0 kegg kegg NA NA no no no no no no Apoptosis B cell receptor signaling pathway 0 0.87944664 0.474131274 kegg kegg NA NA no no no no no no Arachidonic acid metabolism B cell receptor signaling pathway -0.424347826 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism B cell receptor signaling pathway 0 0.79743083 0.526383526 kegg kegg NA NA no up no no no no Arginine biosynthesis B cell receptor signaling pathway 0 0.62944664 0 kegg kegg NA NA no no no no no no Autophagy - animal B cell receptor signaling pathway 0 0.760869565 0 kegg kegg NA NA no no no no no no Basal transcription factors B cell receptor signaling pathway 0 -0.596837945 0 kegg kegg NA NA no no no no no no Base excision repair B cell receptor signaling pathway 0 -0.552371542 -0.621106821 kegg kegg NA NA no no no no no no beta-Alanine metabolism B cell receptor signaling pathway 0 0 -0.526126126 kegg kegg NA NA no no no no no no Biosynthesis of amino acids B cell receptor signaling pathway 0 0.53458498 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors B cell receptor signaling pathway -0.602608696 -0.71541502 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids B cell receptor signaling pathway 0 -0.419960474 -0.614671815 kegg kegg NA NA no no no no no no Butanoate metabolism B cell receptor signaling pathway 0 -0.694664032 -0.645817246 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway B cell receptor signaling pathway 0.631304348 0.941699605 0.84041184 kegg kegg NA NA no no no no no no cAMP signaling pathway B cell receptor signaling pathway 0 0.645256917 0.505791506 yes kegg kegg NA NA no up up no no no Cardiac muscle contraction B cell receptor signaling pathway 0 -0.580039526 0 kegg kegg NA NA no no up no no no Cell adhesion molecules B cell receptor signaling pathway 0 0.498023715 0 kegg kegg NA NA no no no no no no Cell cycle B cell receptor signaling pathway 0 -0.705533597 0 kegg kegg NA NA no no no no no no Cellular senescence B cell receptor signaling pathway 0 0.618577075 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway B cell receptor signaling pathway 0.405217391 0.690711462 0.446846847 kegg kegg NA NA no no no no no no Chemokine signaling pathway B cell receptor signaling pathway 0 0.705533597 0.457657658 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) B cell receptor signaling pathway 0 -0.714426877 -0.456113256 kegg kegg NA NA no no no no no no Complement and coagulation cascades B cell receptor signaling pathway 0 0.538537549 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism B cell receptor signaling pathway -0.620869565 -0.738142292 -0.727155727 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway B cell receptor signaling pathway 0 0.619565217 0.540540541 kegg kegg NA NA no no no no no no DNA replication B cell receptor signaling pathway 0 -0.825098814 -0.481081081 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 B cell receptor signaling pathway -0.528695652 -0.7756917 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes B cell receptor signaling pathway -0.439130435 -0.673913043 0 kegg kegg NA NA no no no no no no ECM-receptor interaction B cell receptor signaling pathway -0.453913043 -0.47826087 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance B cell receptor signaling pathway 0 -0.532608696 0 kegg kegg NA NA no no no no no no Endocytosis B cell receptor signaling pathway 0 0.516798419 0 kegg kegg NA NA no no no no no no ErbB signaling pathway B cell receptor signaling pathway 0.49826087 0.468379447 0 kegg kegg NA NA no no no no no no Ether lipid metabolism B cell receptor signaling pathway 0 -0.489130435 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway B cell receptor signaling pathway 0 -0.530632411 -0.53024453 kegg kegg NA NA no no no no no no Fatty acid biosynthesis B cell receptor signaling pathway 0 0.675889328 0 kegg kegg NA NA no no no no no no Fatty acid elongation B cell receptor signaling pathway 0 0 -0.605405405 kegg kegg NA NA no no no no no no Focal adhesion B cell receptor signaling pathway 0 -0.492094862 0 kegg kegg NA NA no up up no no no FoxO signaling pathway B cell receptor signaling pathway 0 0 -0.466666667 kegg kegg NA NA no no no no no no Galactose metabolism B cell receptor signaling pathway 0 0.46541502 0 kegg kegg NA NA no no no no no no Gap junction B cell receptor signaling pathway -0.48173913 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism B cell receptor signaling pathway -0.463478261 -0.691699605 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism B cell receptor signaling pathway 0.483478261 0 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" B cell receptor signaling pathway -0.532173913 -0.595849802 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis B cell receptor signaling pathway -0.55826087 -0.519762846 -0.403088803 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate B cell receptor signaling pathway 0 0.720355731 0.46975547 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation B cell receptor signaling pathway 0 0.499011858 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series B cell receptor signaling pathway 0 -0.489130435 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series B cell receptor signaling pathway 0.692173913 0.504940711 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism B cell receptor signaling pathway 0 0.652173913 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway B cell receptor signaling pathway 0 -0.490118577 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway B cell receptor signaling pathway 0 -0.530632411 0 kegg kegg NA NA no no no no no no Hippo signaling pathway B cell receptor signaling pathway 0 -0.549407115 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species B cell receptor signaling pathway 0.713043478 0.716403162 0.457657658 kegg kegg NA NA no no no no no no Homologous recombination B cell receptor signaling pathway 0 0 -0.593050193 kegg kegg NA NA no no no no no no IL-17 signaling pathway B cell receptor signaling pathway 0.52173913 0.692687747 0.544916345 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway B cell receptor signaling pathway 0 0.600790514 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species B cell receptor signaling pathway 0 0 -0.603861004 kegg kegg NA NA no no no no no no Lysosome B cell receptor signaling pathway 0.555652174 0.564229249 0.498326898 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis B cell receptor signaling pathway 0.49826087 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 B cell receptor signaling pathway -0.548695652 -0.717391304 0 kegg kegg NA NA no no no no no no Mismatch repair B cell receptor signaling pathway 0 -0.781620553 -0.646846847 kegg kegg NA NA no no no no no no Mitophagy - animal B cell receptor signaling pathway 0 -0.433794466 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway B cell receptor signaling pathway 0 -0.482213439 0 kegg kegg NA NA no no no no no no mTOR signaling pathway B cell receptor signaling pathway 0 -0.516798419 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis B cell receptor signaling pathway -0.405217391 0 -0.430888031 kegg kegg NA NA no no no no no no N-Glycan biosynthesis B cell receptor signaling pathway 0 -0.706521739 -0.458944659 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity B cell receptor signaling pathway 0 0.543478261 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction B cell receptor signaling pathway 0 0.437747036 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation B cell receptor signaling pathway 0 0.498023715 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway B cell receptor signaling pathway 0.614782609 0.85770751 0.665122265 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism B cell receptor signaling pathway 0 0.706521739 0.401287001 kegg kegg NA NA no no no no no no Nitrogen metabolism B cell receptor signaling pathway 0 0.595849802 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway B cell receptor signaling pathway 0 0.837944664 0 kegg kegg NA NA no no no no no no Non-homologous end-joining B cell receptor signaling pathway -0.451304348 -0.529644269 -0.733333333 kegg kegg NA NA no no no no no no Notch signaling pathway B cell receptor signaling pathway 0.68 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair B cell receptor signaling pathway 0 -0.82312253 -0.694465894 kegg kegg NA NA no no no no no no One carbon pool by folate B cell receptor signaling pathway -0.405217391 -0.808300395 -0.451480051 kegg kegg NA NA no no no no no no Oocyte meiosis B cell receptor signaling pathway 0 -0.649209486 -0.431145431 kegg kegg NA NA no no no no no no Osteoclast differentiation B cell receptor signaling pathway 0.531304348 0.82312253 0.654826255 kegg kegg NA NA no no no no no no Oxidative phosphorylation B cell receptor signaling pathway 0 -0.602766798 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis B cell receptor signaling pathway 0 0.596837945 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions B cell receptor signaling pathway -0.491304348 -0.68972332 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway B cell receptor signaling pathway 0 0.558300395 0 kegg kegg NA NA no no no no no no Peroxisome B cell receptor signaling pathway 0 0.489130435 0 kegg kegg NA NA no no no no no no Phagosome B cell receptor signaling pathway 0 0.513833992 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism B cell receptor signaling pathway -0.463478261 -0.616600791 -0.416988417 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system B cell receptor signaling pathway 0 -0.451581028 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway B cell receptor signaling pathway 0 0.643280632 0 kegg kegg NA NA no up up no no no Platinum drug resistance B cell receptor signaling pathway 0 0 -0.413642214 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism B cell receptor signaling pathway -0.59826087 -0.509881423 0 kegg kegg NA NA no no no no no no PPAR signaling pathway B cell receptor signaling pathway 0 0.739130435 0.500643501 kegg kegg NA NA no no no no no no Prevotella B cell receptor signaling pathway -0.5388413 0 0 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis B cell receptor signaling pathway 0 -0.467391304 -0.419047619 kegg kegg NA NA no no no no no no Propanoate metabolism B cell receptor signaling pathway -0.590434783 -0.697628458 -0.703989704 kegg kegg NA NA no no no no no no Proteasome B cell receptor signaling pathway 0 -0.602766798 0 kegg kegg NA NA no no no no no no Protein export B cell receptor signaling pathway 0 -0.636363636 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum B cell receptor signaling pathway -0.433043478 -0.698616601 -0.477734878 kegg kegg NA NA no no no no no no Purine metabolism B cell receptor signaling pathway -0.486956522 -0.5256917 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism B cell receptor signaling pathway 0 -0.760869565 0 kegg kegg NA NA no no no no no no Pyruvate metabolism B cell receptor signaling pathway -0.557391304 -0.785573123 -0.739253539 kegg kegg NA NA no no no no no no Ras signaling pathway B cell receptor signaling pathway 0 -0.599802372 0 yes kegg kegg NA NA no up up no no no Renin-angiotensin system B cell receptor signaling pathway 0 0.631422925 0 kegg kegg NA NA no no no no no no Retinol metabolism B cell receptor signaling pathway -0.504347826 -0.649209486 -0.440669241 kegg kegg NA NA no no no no no no Ribosome B cell receptor signaling pathway 0 -0.604743083 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes B cell receptor signaling pathway 0 -0.695652174 -0.413642214 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway B cell receptor signaling pathway 0.508695652 0.840909091 0.681338481 kegg kegg NA NA no no no no no no RNA degradation B cell receptor signaling pathway 0 -0.572134387 0 kegg kegg NA NA no no no no no no RNA polymerase B cell receptor signaling pathway 0 -0.738142292 -0.430630631 kegg kegg NA NA no no no no no no RNA transport B cell receptor signaling pathway 0 -0.437747036 0 kegg kegg NA NA no no no no no no Sarcina B cell receptor signaling pathway 0 0.466781936 0 Genus kegg 0.0703 NA no no no no no no SNARE interactions in vesicular transport B cell receptor signaling pathway 0 0.567193676 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism B cell receptor signaling pathway 0.444347826 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway B cell receptor signaling pathway 0 0.634387352 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism B cell receptor signaling pathway 0 0.601778656 0 kegg kegg NA NA no no no no no no Steroid biosynthesis B cell receptor signaling pathway 0 -0.740118577 -0.64993565 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis B cell receptor signaling pathway 0 -0.583992095 0 kegg kegg NA NA no no no no no no Sulfur metabolism B cell receptor signaling pathway 0 -0.484189723 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies B cell receptor signaling pathway 0 -0.781620553 -0.637323037 kegg kegg NA NA no no no no no no T cell receptor signaling pathway B cell receptor signaling pathway 0 0.518774704 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis B cell receptor signaling pathway 0 -0.485177866 -0.400514801 kegg kegg NA NA no no no no no no TGF-beta signaling pathway B cell receptor signaling pathway 0 -0.542490119 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation B cell receptor signaling pathway 0.562608696 0.592885375 0 kegg kegg NA NA no no no no no no Th17 cell differentiation B cell receptor signaling pathway 0.549565217 0.615612648 0 kegg kegg NA NA no no no no no no Thiamine metabolism B cell receptor signaling pathway 0 -0.559288538 0 kegg kegg NA NA no no no no no no Tight junction B cell receptor signaling pathway 0 -0.45256917 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway B cell receptor signaling pathway 0.490434783 0.933794466 0.782754183 yes kegg kegg NA NA no no no no no no Tryptophan metabolism B cell receptor signaling pathway 0 -0.538537549 -0.412097812 kegg kegg NA NA no up no no no no Tyrosine metabolism B cell receptor signaling pathway -0.65826087 -0.785573123 -0.726898327 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis B cell receptor signaling pathway 0 -0.675889328 -0.573230373 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis B cell receptor signaling pathway 0 -0.554347826 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" B cell receptor signaling pathway 0 -0.690711462 -0.626512227 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis B cell receptor signaling pathway 0 -0.576086957 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction B cell receptor signaling pathway 0 -0.632411067 0 kegg kegg NA NA no no no no no no VEGF signaling pathway B cell receptor signaling pathway 0.549565217 0.579051383 0 kegg kegg NA NA no no no no no no Wnt signaling pathway B cell receptor signaling pathway 0 -0.630434783 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Bacterial invasion of epithelial cells 0.42173913 0 0 kegg kegg NA NA no no no no no no ABC transporters Bacterial invasion of epithelial cells 0 -0.696640316 0 kegg kegg NA NA no up up no no no Adherens junction Bacterial invasion of epithelial cells 0.906956522 0.922924901 0.912998713 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Bacterial invasion of epithelial cells 0 -0.601778656 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Bacterial invasion of epithelial cells 0 -0.414031621 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Bacterial invasion of epithelial cells 0 -0.508893281 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Bacterial invasion of epithelial cells 0.405217391 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Bacterial invasion of epithelial cells 0 0 0.462290862 kegg kegg NA NA no no no no no no Antigen processing and presentation Bacterial invasion of epithelial cells 0 0.415019763 0 kegg kegg NA NA no no no no no no Apoptosis Bacterial invasion of epithelial cells 0.623478261 0 0.48030888 kegg kegg NA NA no no no no no no Apoptosis - multiple species Bacterial invasion of epithelial cells -0.665217391 -0.68972332 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Bacterial invasion of epithelial cells 0 -0.436758893 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Bacterial invasion of epithelial cells 0 0.447628458 0 kegg kegg NA NA no no no no no no Autophagy - animal Bacterial invasion of epithelial cells -0.691304348 -0.75 0 kegg kegg NA NA no no no no no no Autophagy - other Bacterial invasion of epithelial cells -0.829565217 -0.796442688 -0.475160875 kegg kegg NA NA no no no no no no Basal transcription factors Bacterial invasion of epithelial cells -0.717391304 0 0 kegg kegg NA NA no no no no no no Base excision repair Bacterial invasion of epithelial cells -0.546086957 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Bacterial invasion of epithelial cells 0.482608696 0.520750988 0.418018018 kegg kegg NA NA no no no no no no Bifidobacterium Bacterial invasion of epithelial cells 0 0.473998482 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Biosynthesis of amino acids Bacterial invasion of epithelial cells 0.466956522 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Bacterial invasion of epithelial cells 0 0 0.434234234 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Bacterial invasion of epithelial cells -0.428695652 0 -0.517889318 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Bacterial invasion of epithelial cells -0.540869565 -0.475296443 0 kegg kegg NA NA no no no no no no Carbon metabolism Bacterial invasion of epithelial cells 0.537391304 0.683794466 0.443758044 kegg kegg NA NA no no no no no no Cardiac muscle contraction Bacterial invasion of epithelial cells 0 0.423913043 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Bacterial invasion of epithelial cells 0.455652174 0 0 kegg kegg NA NA no no no no no no Cell cycle Bacterial invasion of epithelial cells -0.406956522 0 0 kegg kegg NA NA no no no no no no Cholesterol metabolism Bacterial invasion of epithelial cells 0 0.416007905 0 yes kegg kegg NA NA no no up no no no Cholinergic synapse Bacterial invasion of epithelial cells -0.427826087 0 0 kegg kegg NA NA no no no no no no Circadian entrainment Bacterial invasion of epithelial cells 0 0.494071146 0 kegg kegg NA NA no up up no no no Circadian rhythm Bacterial invasion of epithelial cells -0.665217391 0 -0.440926641 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Bacterial invasion of epithelial cells 0 0.434782609 0 kegg kegg NA NA no no no no no no Clostridium Bacterial invasion of epithelial cells 0 0.522647208 0 Genus kegg 0.925 NA no no no no no no Complement and coagulation cascades Bacterial invasion of epithelial cells 0 0 0.488803089 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Bacterial invasion of epithelial cells 0 0 0.675160875 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Bacterial invasion of epithelial cells 0 0.527667984 0.403861004 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Bacterial invasion of epithelial cells 0 0.669960474 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Bacterial invasion of epithelial cells -0.45826087 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Bacterial invasion of epithelial cells -0.47826087 -0.596837945 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Bacterial invasion of epithelial cells 0 -0.414031621 0 kegg kegg NA NA no no no no no no Fatty acid elongation Bacterial invasion of epithelial cells 0.500869565 0.51284585 0.446589447 kegg kegg NA NA no no no no no no Focal adhesion Bacterial invasion of epithelial cells 0.885217391 0.946640316 0.9003861 kegg kegg NA NA no up up no no no FoxO signaling pathway Bacterial invasion of epithelial cells -0.449565217 -0.707509881 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Bacterial invasion of epithelial cells 0.405217391 -0.423913043 0 kegg kegg NA NA no no no no no no Galactose metabolism Bacterial invasion of epithelial cells 0.512173913 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Bacterial invasion of epithelial cells 0.802608696 0.822134387 0.810553411 kegg kegg NA NA no no no no no no Glycerolipid metabolism Bacterial invasion of epithelial cells 0 -0.654150198 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Bacterial invasion of epithelial cells -0.513913043 -0.752964427 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Bacterial invasion of epithelial cells 0 0.62944664 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Bacterial invasion of epithelial cells 0 -0.574110672 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Bacterial invasion of epithelial cells 0.610434783 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Bacterial invasion of epithelial cells 0 -0.511857708 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Bacterial invasion of epithelial cells 0 -0.416996047 0 kegg kegg NA NA no no no no no no GnRH secretion Bacterial invasion of epithelial cells -0.519130435 -0.616600791 0 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Bacterial invasion of epithelial cells 0 -0.584980237 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Bacterial invasion of epithelial cells 0 0.570158103 0.507850708 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Bacterial invasion of epithelial cells -0.48173913 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Bacterial invasion of epithelial cells 0.824347826 0.855731225 0.876447876 kegg kegg NA NA no no no no no no Homologous recombination Bacterial invasion of epithelial cells 0 -0.62055336 0 kegg kegg NA NA no no no no no no Huntington disease Bacterial invasion of epithelial cells 0 0 0.415444015 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Bacterial invasion of epithelial cells 0 -0.646245059 0 kegg kegg NA NA no no no no no no Insulin resistance Bacterial invasion of epithelial cells -0.667826087 -0.633399209 -0.686743887 kegg kegg NA NA no no no no no no Insulin signaling pathway Bacterial invasion of epithelial cells -0.486086957 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Bacterial invasion of epithelial cells 0 0.515810277 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Bacterial invasion of epithelial cells 0 -0.713438735 0 kegg kegg NA NA no no no no no no Lachnospira Bacterial invasion of epithelial cells 0 0.619718329 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Leukocyte transendothelial migration Bacterial invasion of epithelial cells 0.777391304 0.833992095 0.820849421 kegg kegg NA NA no no no no no no Long-term potentiation Bacterial invasion of epithelial cells -0.505217391 0 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Bacterial invasion of epithelial cells -0.473043478 -0.672924901 0 kegg kegg NA NA no no no no no no Lysine degradation Bacterial invasion of epithelial cells -0.480869565 -0.515810277 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Bacterial invasion of epithelial cells 0 -0.581027668 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Bacterial invasion of epithelial cells 0 0.613636364 0.482625483 kegg kegg NA NA no no no no no no mRNA surveillance pathway Bacterial invasion of epithelial cells -0.540869565 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Bacterial invasion of epithelial cells -0.426086957 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Bacterial invasion of epithelial cells 0 -0.56916996 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Bacterial invasion of epithelial cells 0.452173913 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Bacterial invasion of epithelial cells 0.562608696 0 0.467953668 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Bacterial invasion of epithelial cells 0 -0.621541502 -0.648391248 kegg kegg NA NA no no no no no no Nicotine addiction Bacterial invasion of epithelial cells 0 -0.565217391 0 kegg kegg NA NA no up up no no no Nitrogen metabolism Bacterial invasion of epithelial cells 0 -0.476284585 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Bacterial invasion of epithelial cells 0 -0.458498024 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Bacterial invasion of epithelial cells 0 0.428853755 0 kegg kegg NA NA no no no no no no Notch signaling pathway Bacterial invasion of epithelial cells 0 -0.46541502 0 kegg kegg NA NA no no no no no no Oocyte meiosis Bacterial invasion of epithelial cells -0.430434783 0.429841897 0 kegg kegg NA NA no no no no no no Other glycan degradation Bacterial invasion of epithelial cells 0 -0.467391304 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Bacterial invasion of epithelial cells -0.587826087 -0.616600791 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Bacterial invasion of epithelial cells 0 0.441699605 0.423938224 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Bacterial invasion of epithelial cells 0.848695652 0.811264822 0.671557272 kegg kegg NA NA no no no no no no p53 signaling pathway Bacterial invasion of epithelial cells -0.791304348 -0.804347826 -0.503217503 kegg kegg NA NA no no no no no no Pentose phosphate pathway Bacterial invasion of epithelial cells 0.56 0 0 kegg kegg NA NA no no no no no no Phagosome Bacterial invasion of epithelial cells 0.546956522 0 0.457400257 kegg kegg NA NA no no no no no no Phenylalanine metabolism Bacterial invasion of epithelial cells 0.646086957 0.59486166 0.55032175 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Bacterial invasion of epithelial cells -0.53826087 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Bacterial invasion of epithelial cells 0 -0.440711462 0 kegg kegg NA NA no up up no no no Phototransduction Bacterial invasion of epithelial cells 0 0.668972332 0 kegg kegg NA NA no no no no no no Platelet activation Bacterial invasion of epithelial cells 0.866956522 0.90513834 0.831402831 kegg kegg NA NA no no no no no no Platinum drug resistance Bacterial invasion of epithelial cells -0.726086957 -0.659090909 0 kegg kegg NA NA no no no no no no Prevotella Bacterial invasion of epithelial cells 0 -0.416691439 0 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Bacterial invasion of epithelial cells 0 0.423913043 0.429343629 kegg kegg NA NA no no no no no no Prion disease Bacterial invasion of epithelial cells 0 0.480237154 0.520978121 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Bacterial invasion of epithelial cells -0.569565217 -0.641304348 0 kegg kegg NA NA no no no no no no Proteasome Bacterial invasion of epithelial cells 0 0.572134387 0 kegg kegg NA NA no no no no no no Protein export Bacterial invasion of epithelial cells -0.602608696 0.457509881 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Bacterial invasion of epithelial cells 0 0 -0.402574003 kegg kegg NA NA no no no no no no Rap1 signaling pathway Bacterial invasion of epithelial cells 0.805217391 0.855731225 0.791248391 kegg kegg NA NA no no no no no no Ras signaling pathway Bacterial invasion of epithelial cells 0 0.448616601 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Bacterial invasion of epithelial cells 0.710434783 0.746047431 0.775032175 kegg kegg NA NA no no no no no no Renin secretion Bacterial invasion of epithelial cells 0 0.447628458 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Bacterial invasion of epithelial cells 0 0.496047431 0 kegg kegg NA NA no no up no no no Ribosome Bacterial invasion of epithelial cells -0.432173913 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Bacterial invasion of epithelial cells -0.568695652 0 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Bacterial invasion of epithelial cells -0.463478261 -0.627470356 -0.616473616 kegg kegg NA NA no no no no no no RNA degradation Bacterial invasion of epithelial cells -0.502608696 0 0 kegg kegg NA NA no no no no no no RNA polymerase Bacterial invasion of epithelial cells -0.743478261 0 0 kegg kegg NA NA no no no no no no Salivary secretion Bacterial invasion of epithelial cells 0 0.53458498 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Bacterial invasion of epithelial cells -0.62 -0.546442688 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Bacterial invasion of epithelial cells -0.503478261 -0.57312253 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Bacterial invasion of epithelial cells 0 -0.601778656 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Bacterial invasion of epithelial cells 0.413043478 0.444664032 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Bacterial invasion of epithelial cells -0.809565217 0 0 kegg kegg NA NA no no no no no no Spliceosome Bacterial invasion of epithelial cells -0.710434783 -0.712450593 0 kegg kegg NA NA no no no no no no Sulfur metabolism Bacterial invasion of epithelial cells 0.426086957 0 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Bacterial invasion of epithelial cells 0 -0.670948617 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Bacterial invasion of epithelial cells -0.488695652 -0.757905138 -0.405662806 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Bacterial invasion of epithelial cells -0.440869565 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Bacterial invasion of epithelial cells 0 0.470355731 0 kegg kegg NA NA no no no no no no Thermogenesis Bacterial invasion of epithelial cells 0 0.438735178 0.408751609 kegg kegg NA NA no no no no no no Thiamine metabolism Bacterial invasion of epithelial cells 0 0 -0.47953668 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Bacterial invasion of epithelial cells 0.760869565 0.776679842 0.724324324 kegg kegg NA NA no no no no no no Tight junction Bacterial invasion of epithelial cells 0.907826087 0.937747036 0.769111969 kegg kegg NA NA no no no no no no TNF signaling pathway Bacterial invasion of epithelial cells -0.459130435 -0.513833992 -0.400772201 kegg kegg NA NA no no no no no no Tryptophan metabolism Bacterial invasion of epithelial cells 0 0.499011858 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Bacterial invasion of epithelial cells -0.489565217 -0.666007905 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Bacterial invasion of epithelial cells -0.431304348 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Bacterial invasion of epithelial cells 0 0.517786561 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Bacterial invasion of epithelial cells 0 0 0.509395109 kegg kegg NA NA no no no no no no Eggerthella Bacteroides 0.488630222 0 0 LPS-producing Genus Genus 0.912 0.000267 no no no dn dn up Adrenergic signaling in cardiomyocytes Basal cell carcinoma 0 0.470355731 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Basal cell carcinoma -0.406956522 -0.419960474 -0.524066924 kegg kegg NA NA no no no no no no Alcoholism Basal cell carcinoma 0 -0.543478261 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Basal cell carcinoma 0.480869565 0.504940711 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Basal cell carcinoma 0 -0.454545455 0 kegg kegg NA NA no no no no no no Alzheimer disease Basal cell carcinoma 0.452173913 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Basal cell carcinoma -0.54 0 0 kegg kegg NA NA no no no no no no Amoebiasis Basal cell carcinoma 0 0 -0.54002574 kegg kegg NA NA no no no no no no AMPK signaling pathway Basal cell carcinoma 0 0.427865613 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Basal cell carcinoma 0.533913043 0 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Basal cell carcinoma -0.504347826 0 -0.482625483 kegg kegg NA NA no no no no no no Apelin signaling pathway Basal cell carcinoma 0.406956522 0 0 kegg kegg NA NA no no no no no no Apoptosis Basal cell carcinoma 0 0 -0.411583012 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Basal cell carcinoma 0 -0.423913043 -0.596911197 kegg kegg NA NA no no no no no no Arginine and proline metabolism Basal cell carcinoma -0.556521739 -0.437747036 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Basal cell carcinoma -0.46 -0.489130435 -0.598455598 kegg kegg NA NA no no no no no no Autophagy - other Basal cell carcinoma 0 0.508893281 0.706821107 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Basal cell carcinoma 0 0 -0.465894466 kegg kegg NA NA no no no no no no Basal transcription factors Basal cell carcinoma 0 0.429841897 0.52020592 kegg kegg NA NA no no no no no no Base excision repair Basal cell carcinoma 0 0.453557312 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Basal cell carcinoma -0.41826087 0 -0.496525097 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Basal cell carcinoma -0.556521739 -0.656126482 -0.760875161 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Basal cell carcinoma -0.504347826 -0.552371542 -0.450965251 kegg kegg NA NA no no no no no no Calcium signaling pathway Basal cell carcinoma 0.517391304 0.537549407 0.578635779 kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Basal cell carcinoma 0 0 0.444272844 kegg kegg NA NA no no no no no no Carbon metabolism Basal cell carcinoma -0.496521739 -0.548418972 -0.719433719 kegg kegg NA NA no no no no no no Cardiac muscle contraction Basal cell carcinoma 0.468695652 0 0 kegg kegg NA NA no no up no no no Cell cycle Basal cell carcinoma 0 0.563241107 0.643500644 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Basal cell carcinoma 0 -0.650197628 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Basal cell carcinoma -0.78 -0.764822134 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Basal cell carcinoma 0 0.538537549 0 kegg kegg NA NA no no no no no no Cholinergic synapse Basal cell carcinoma 0 0 0.512998713 kegg kegg NA NA no no no no no no Circadian rhythm Basal cell carcinoma 0.446956522 0.787549407 0.86975547 kegg kegg NA NA no no no no no no Cocaine addiction Basal cell carcinoma 0.471304348 0.450592885 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Basal cell carcinoma 0 -0.782608696 -0.63989704 kegg kegg NA NA no no no no no no Colorectal cancer Basal cell carcinoma 0.685217391 0.687747036 0.693178893 kegg kegg NA NA no no no no no no Complement and coagulation cascades Basal cell carcinoma -0.491304348 -0.660079051 -0.737966538 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Basal cell carcinoma 0.66 0 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Basal cell carcinoma 0.437391304 0.471343874 0 kegg kegg NA NA no no up no no no Cushing syndrome Basal cell carcinoma 0.622608696 0.612648221 0.546718147 kegg kegg NA NA no no up no no no Cytokine-cytokine receptor interaction Basal cell carcinoma 0 -0.663043478 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Basal cell carcinoma -0.446956522 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Basal cell carcinoma -0.484347826 0 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Basal cell carcinoma 0.571304348 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Basal cell carcinoma 0.416521739 0 0 kegg kegg NA NA no no no no no no Endometrial cancer Basal cell carcinoma 0.58 0 0.742084942 kegg kegg NA NA no no no no no no ErbB signaling pathway Basal cell carcinoma 0.49826087 0.471343874 0.633462033 kegg kegg NA NA no no no no no no Ether lipid metabolism Basal cell carcinoma 0.545217391 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Basal cell carcinoma 0 0 0.406692407 kegg kegg NA NA no no no no no no Fat digestion and absorption Basal cell carcinoma -0.603478261 -0.750988142 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Basal cell carcinoma -0.460869565 -0.440711462 0 kegg kegg NA NA no no no no no no Fatty acid degradation Basal cell carcinoma -0.495652174 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Basal cell carcinoma -0.47826087 -0.4743083 -0.477477477 kegg kegg NA NA no no no no no no Fatty acid metabolism Basal cell carcinoma -0.603478261 -0.593873518 -0.451222651 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Basal cell carcinoma -0.570434783 -0.695652174 -0.747490347 kegg kegg NA NA no no no no no no Folate biosynthesis Basal cell carcinoma 0 0.623517787 0 kegg kegg NA NA no no no no no no GABAergic synapse Basal cell carcinoma -0.483478261 -0.494071146 -0.436808237 kegg kegg NA NA no up up no no no Galactose metabolism Basal cell carcinoma -0.412173913 0 0 kegg kegg NA NA no no no no no no Glioma Basal cell carcinoma 0 0 0.499099099 kegg kegg NA NA no no no no no no Glucagon signaling pathway Basal cell carcinoma 0 0.459486166 0.525868726 kegg kegg NA NA no no no no no no Glutathione metabolism Basal cell carcinoma 0 0 -0.503989704 kegg kegg NA NA no no no no no no Glycerolipid metabolism Basal cell carcinoma 0 0 0.641184041 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Basal cell carcinoma 0 0 0.64993565 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Basal cell carcinoma -0.468695652 0 -0.525868726 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Basal cell carcinoma 0 0.505928854 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Basal cell carcinoma 0.684347826 0.811264822 0.52046332 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Basal cell carcinoma 0.528695652 0 0.524839125 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Basal cell carcinoma -0.46173913 -0.497035573 -0.580952381 kegg kegg NA NA no no no no no no GnRH secretion Basal cell carcinoma 0.492173913 0.467391304 0.619047619 kegg kegg NA NA no up up no no no GnRH signaling pathway Basal cell carcinoma 0 0.419960474 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Basal cell carcinoma 0.593913043 0.545454545 0.82007722 kegg kegg NA NA no no no no no no Hepatitis B Basal cell carcinoma 0 0 0.544916345 kegg kegg NA NA no no no no no no Hepatitis C Basal cell carcinoma 0 0 0.537709138 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Basal cell carcinoma -0.429565217 0 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Basal cell carcinoma -0.415652174 0 0 kegg kegg NA NA no no no no no no Huntington disease Basal cell carcinoma 0.483478261 0 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Basal cell carcinoma 0 -0.59486166 -0.406692407 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Basal cell carcinoma 0 0 0.508880309 kegg kegg NA NA no no no no no no Insulin resistance Basal cell carcinoma 0.449565217 0 0.775546976 kegg kegg NA NA no no no no no no Insulin secretion Basal cell carcinoma 0.545217391 0.568181818 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Basal cell carcinoma 0.468695652 0 0 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Basal cell carcinoma 0.410434783 0 0 kegg kegg NA NA no no dn no no no Leishmaniasis Basal cell carcinoma 0 0 -0.43037323 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Basal cell carcinoma 0 0 -0.574002574 kegg kegg NA NA no no no no no no Long-term potentiation Basal cell carcinoma 0 0 0.533333333 kegg kegg NA NA no no up no no no Longevity regulating pathway Basal cell carcinoma 0.416521739 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Basal cell carcinoma 0 -0.466403162 -0.46048906 kegg kegg NA NA no no no no no no Lysine degradation Basal cell carcinoma 0.626086957 0.789525692 0.788416988 kegg kegg NA NA no no no no no no Lysosome Basal cell carcinoma 0 -0.589920949 -0.458944659 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Basal cell carcinoma 0.846956522 0.875494071 0.803603604 kegg kegg NA NA no no no no no no MAPK signaling pathway Basal cell carcinoma 0 0 0.413127413 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Basal cell carcinoma 0 0 0.419305019 kegg kegg NA NA no up no no no no Melanogenesis Basal cell carcinoma 0.435652174 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Basal cell carcinoma -0.50173913 0 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Basal cell carcinoma 0 0 0.686229086 kegg kegg NA NA no no no no no no Mitophagy - animal Basal cell carcinoma 0.443478261 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Basal cell carcinoma 0.58 0.805335968 0.842471042 kegg kegg NA NA no no no no no no mTOR signaling pathway Basal cell carcinoma 0.54173913 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Basal cell carcinoma 0.406086957 0.549407115 0.501930502 kegg kegg NA NA no no no no no no Necroptosis Basal cell carcinoma 0 0 -0.407207207 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Basal cell carcinoma -0.507826087 -0.677865613 -0.614929215 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Basal cell carcinoma 0.430434783 0 0.496782497 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Basal cell carcinoma -0.523478261 -0.72826087 -0.738996139 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Basal cell carcinoma 0 0 0.412355212 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Basal cell carcinoma -0.496521739 -0.456521739 0 kegg kegg NA NA no no no no no no Nicotine addiction Basal cell carcinoma 0 0.476284585 0.421621622 kegg kegg NA NA no up up no no no Nitrogen metabolism Basal cell carcinoma 0 -0.484189723 -0.470527671 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Basal cell carcinoma -0.511304348 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Basal cell carcinoma 0.491304348 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Basal cell carcinoma 0 0 -0.431402831 kegg kegg NA NA no no no no no no Notch signaling pathway Basal cell carcinoma 0 0.443675889 0.62960103 kegg kegg NA NA no no no no no no Olfactory transduction Basal cell carcinoma -0.509565217 -0.847826087 -0.594079794 kegg kegg NA NA no no no no no no One carbon pool by folate Basal cell carcinoma 0 0 0.422136422 kegg kegg NA NA no no no no no no Osteoclast differentiation Basal cell carcinoma 0 -0.41798419 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Basal cell carcinoma 0.560869565 0.645256917 0.684169884 kegg kegg NA NA no no no no no no Oxidative phosphorylation Basal cell carcinoma 0.445217391 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Basal cell carcinoma 0 -0.488142292 -0.730501931 kegg kegg NA NA no no no no no no p53 signaling pathway Basal cell carcinoma 0 0 0.475418275 kegg kegg NA NA no no no no no no Pancreatic cancer Basal cell carcinoma 0 0.539525692 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Basal cell carcinoma -0.474782609 -0.572134387 -0.477992278 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Basal cell carcinoma 0.453913043 0 0 kegg kegg NA NA no no no no no no Parkinson disease Basal cell carcinoma 0.506956522 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Basal cell carcinoma -0.437391304 -0.531620553 -0.580952381 kegg kegg NA NA no no no no no no Pathways in cancer Basal cell carcinoma 0.440869565 0 0.568082368 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Basal cell carcinoma 0.516521739 0 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Basal cell carcinoma 0 -0.684782609 -0.663835264 kegg kegg NA NA no no no no no no Peroxisome Basal cell carcinoma -0.533043478 -0.559288538 -0.605405405 kegg kegg NA NA no no no no no no Pertussis Basal cell carcinoma -0.739130435 -0.650197628 -0.672329472 kegg kegg NA NA no no dn no no no Phagosome Basal cell carcinoma 0 -0.460474308 -0.493951094 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Basal cell carcinoma 0.509565217 0.43972332 0.737451737 kegg kegg NA NA no no no no no no Platelet activation Basal cell carcinoma 0 0 -0.421106821 kegg kegg NA NA no no no no no no Platinum drug resistance Basal cell carcinoma 0 0.461462451 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Basal cell carcinoma -0.440869565 0 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Basal cell carcinoma 0 -0.518774704 -0.631402831 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Basal cell carcinoma 0 0.484189723 0.599227799 kegg kegg NA NA no no no no no no Prostate cancer Basal cell carcinoma 0.486086957 0 0.658172458 kegg kegg NA NA no no no no no no Protein export Basal cell carcinoma 0 0 0.536164736 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Basal cell carcinoma 0 0.51284585 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Basal cell carcinoma 0.440869565 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Basal cell carcinoma -0.528695652 0 0 kegg kegg NA NA no no no no no no Ras signaling pathway Basal cell carcinoma 0 0 0.559330759 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Basal cell carcinoma 0 -0.438735178 -0.447619048 kegg kegg NA NA no no no no no no Renal cell carcinoma Basal cell carcinoma 0.413913043 0 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Basal cell carcinoma -0.466956522 -0.53458498 0 kegg kegg NA NA no no no no no no Retinol metabolism Basal cell carcinoma -0.595652174 0 0 kegg kegg NA NA no no no no no no Ribosome Basal cell carcinoma 0.663478261 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Basal cell carcinoma 0 0.494071146 0.597940798 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Basal cell carcinoma 0 0 0.425225225 kegg kegg NA NA no no no no no no RNA degradation Basal cell carcinoma 0.590434783 0.670948617 0.784041184 kegg kegg NA NA no no no no no no RNA polymerase Basal cell carcinoma 0 0.530632411 0 kegg kegg NA NA no no no no no no Salmonella infection Basal cell carcinoma -0.548695652 -0.551383399 -0.607464607 kegg kegg NA NA no no no no no no Selenocompound metabolism Basal cell carcinoma 0 0 0.437580438 kegg kegg NA NA no no no no no no Serotonergic synapse Basal cell carcinoma 0 0 -0.46023166 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Basal cell carcinoma 0.683478261 0.822134387 0.751608752 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Basal cell carcinoma 0 0 0.426769627 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Basal cell carcinoma 0 0.744071146 0.605405405 kegg kegg NA NA no no no no no no Spliceosome Basal cell carcinoma 0 0.610671937 0.644272844 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Basal cell carcinoma -0.508695652 -0.597826087 -0.810553411 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Basal cell carcinoma -0.46173913 -0.466403162 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Basal cell carcinoma -0.555652174 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Basal cell carcinoma 0 0 -0.548262548 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Basal cell carcinoma 0 -0.802371542 -0.420592021 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Basal cell carcinoma 0 0 0.45019305 kegg kegg NA NA no no no no no no Taste transduction Basal cell carcinoma 0 0 0.65019305 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Basal cell carcinoma 0 0.437747036 0.708622909 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Basal cell carcinoma 0.486956522 0 0.453024453 kegg kegg NA NA no no no no no no Thermogenesis Basal cell carcinoma 0.556521739 0 0 kegg kegg NA NA no no no no no no Tight junction Basal cell carcinoma 0 0 -0.748005148 kegg kegg NA NA no no no no no no Toxoplasmosis Basal cell carcinoma -0.476521739 0 -0.408751609 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Basal cell carcinoma 0 0 0.52046332 kegg kegg NA NA no no no no no no Tuberculosis Basal cell carcinoma -0.496521739 -0.635375494 -0.727670528 kegg kegg NA NA no no dn no no no Tyrosine metabolism Basal cell carcinoma 0 0 -0.462033462 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Basal cell carcinoma 0.525217391 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Basal cell carcinoma 0 0.567193676 0.439124839 kegg kegg NA NA no no no no no no VEGF signaling pathway Basal cell carcinoma 0 0 0.471299871 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Basal cell carcinoma 0 -0.681818182 -0.451994852 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Basal cell carcinoma 0.413913043 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Basal cell carcinoma 0.759130435 0.660079051 0.783783784 kegg kegg NA NA no no no no no no Yersinia infection Basal cell carcinoma 0 -0.580039526 -0.401287001 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Basal transcription factors 0 0.649209486 0.592020592 kegg kegg NA NA no no no no no no Antifolate resistance Basal transcription factors 0 0.433794466 0.440926641 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Basal transcription factors 0 0 -0.531274131 kegg kegg NA NA no no no no no no Arginine and proline metabolism Basal transcription factors 0 -0.488142292 -0.403861004 kegg kegg NA NA no up no no no no Arginine biosynthesis Basal transcription factors 0 0 -0.454568855 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Basal transcription factors 0 0 0.557014157 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Basal transcription factors -0.49826087 -0.643280632 -0.67953668 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Basal transcription factors 0 0.612648221 0 kegg kegg NA NA no no no no no no Butanoate metabolism Basal transcription factors 0 0.488142292 0.489317889 kegg kegg NA NA no no no no no no Carbon metabolism Basal transcription factors 0 0 -0.409009009 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Basal transcription factors 0 0.502964427 0.645045045 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Basal transcription factors 0 0.497035573 0.6 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Basal transcription factors 0.555652174 0 0.491634492 kegg kegg NA NA no no no no no no Ether lipid metabolism Basal transcription factors 0 0.65513834 0.602831403 kegg kegg NA NA no no no no no no Glutathione metabolism Basal transcription factors 0 0 -0.415701416 kegg kegg NA NA no no no no no no Glycerolipid metabolism Basal transcription factors 0 0 0.452767053 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Basal transcription factors 0.440869565 0 0.681081081 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Basal transcription factors 0 0.42687747 -0.449163449 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Basal transcription factors -0.447826087 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Basal transcription factors 0 0 0.405405405 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Basal transcription factors -0.571304348 0 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Basal transcription factors 0 0.633399209 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Basal transcription factors 0.446086957 0.531620553 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Basal transcription factors 0 -0.437747036 -0.424967825 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Basal transcription factors 0 0.414031621 0.624195624 kegg kegg NA NA no no no no no no Linoleic acid metabolism Basal transcription factors 0 0 0.439382239 kegg kegg NA NA no no no no no no Lysine degradation Basal transcription factors 0.509565217 0.585968379 0.731016731 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Basal transcription factors 0 0 0.61956242 kegg kegg NA NA no no no no no no mRNA surveillance pathway Basal transcription factors 0.597391304 0.645256917 0.735649936 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Basal transcription factors 0 0.442687747 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Basal transcription factors 0.58173913 0.648221344 0.680823681 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Basal transcription factors 0 -0.517786561 -0.444530245 kegg kegg NA NA no no no no no no Nitrogen metabolism Basal transcription factors -0.479130435 -0.456521739 -0.494208494 kegg kegg NA NA no no no no no no One carbon pool by folate Basal transcription factors 0.580869565 0.719367589 0.703474903 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Basal transcription factors 0.60173913 0.612648221 0.797683398 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Basal transcription factors 0 0.59486166 0.445817246 kegg kegg NA NA no no no no no no Pentose phosphate pathway Basal transcription factors -0.703478261 -0.731225296 -0.593564994 kegg kegg NA NA no no no no no no Platinum drug resistance Basal transcription factors 0.719130435 0.635375494 0.665379665 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Basal transcription factors 0 0 -0.423680824 kegg kegg NA NA no no no no no no Propanoate metabolism Basal transcription factors 0 0.421936759 0.571685972 kegg kegg NA NA no no no no no no Purine metabolism Basal transcription factors 0 0.470355731 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Basal transcription factors 0 0.52173913 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Basal transcription factors 0 0.496047431 0.490862291 kegg kegg NA NA no no no no no no Retinol metabolism Basal transcription factors 0 0.527667984 0.644530245 kegg kegg NA NA no no no no no no Ribosome Basal transcription factors 0.431304348 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Basal transcription factors 0.84173913 0.849802372 0.893693694 kegg kegg NA NA no no no no no no RNA degradation Basal transcription factors 0.592173913 0.575098814 0.767052767 kegg kegg NA NA no no no no no no RNA polymerase Basal transcription factors 0.853043478 0.82312253 0.81956242 kegg kegg NA NA no no no no no no Selenocompound metabolism Basal transcription factors 0.724347826 0.713438735 0.785070785 kegg kegg NA NA no no no no no no Sphingolipid metabolism Basal transcription factors -0.55826087 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Basal transcription factors 0.616521739 0.678853755 0.598198198 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Basal transcription factors 0 0.437747036 0.448648649 kegg kegg NA NA no no no no no no Sulfur metabolism Basal transcription factors -0.431304348 0 -0.524324324 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Basal transcription factors 0.542608696 0.7756917 0.734362934 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Basal transcription factors 0 0 0.411325611 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Basal transcription factors 0.848695652 0.824110672 0.756241956 kegg kegg NA NA no no no no no no Tryptophan metabolism Basal transcription factors 0 0 0.539253539 kegg kegg NA NA no up no no no no Tyrosine metabolism Basal transcription factors 0 0.47826087 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Basal transcription factors 0 0.602766798 0.678507079 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Basal transcription factors 0 0.581027668 0.611325611 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Basal transcription factors 0.543478261 0.619565217 0.661003861 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Base excision repair 0 0.588932806 0 kegg kegg NA NA no no no no no no ABC transporters Base excision repair 0.49826087 0.52173913 0 kegg kegg NA NA no up up no no no Amino sugar and nucleotide sugar metabolism Base excision repair 0 0.541501976 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Base excision repair 0.633043478 0.693675889 0.717117117 kegg kegg NA NA no no no no no no Antifolate resistance Base excision repair 0 0.75 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Base excision repair 0 0 -0.471299871 kegg kegg NA NA no up no no no no Arginine biosynthesis Base excision repair 0 0 -0.411583012 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Base excision repair 0 0 0.485456885 kegg kegg NA NA no no no no no no Basal transcription factors Base excision repair 0.76173913 0.717391304 0.847104247 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Base excision repair 0 -0.52173913 -0.49034749 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Base excision repair 0 0.687747036 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Base excision repair 0.443478261 0 0.527670528 kegg kegg NA NA no no no no no no Butanoate metabolism Base excision repair 0 0.503952569 0.666924067 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Base excision repair 0 0.466403162 0.659459459 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Base excision repair 0.473913043 0.43972332 0.736936937 kegg kegg NA NA no no no no no no DNA replication Base excision repair 0.800869565 0.739130435 0.841184041 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Base excision repair 0 0.4743083 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Base excision repair 0.514782609 0 0.51042471 kegg kegg NA NA no no no no no no Ether lipid metabolism Base excision repair 0 0.470355731 0.533075933 kegg kegg NA NA no no no no no no Fatty acid elongation Base excision repair 0 0 0.51969112 kegg kegg NA NA no no no no no no Glycerolipid metabolism Base excision repair 0 0.419960474 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Base excision repair 0 0.457509881 0.498069498 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Base excision repair 0 0.524703557 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Base excision repair 0 0.549407115 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Base excision repair -0.756521739 -0.520750988 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Base excision repair 0 0.68972332 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Base excision repair -0.474782609 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Base excision repair 0.646086957 0.524703557 0.410810811 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Base excision repair 0 0.541501976 0.481338481 kegg kegg NA NA no no no no no no Linoleic acid metabolism Base excision repair 0 0 0.40978121 kegg kegg NA NA no no no no no no Lysine degradation Base excision repair 0.63826087 0.711462451 0.537194337 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Base excision repair 0 0.481225296 0.417503218 kegg kegg NA NA no no no no no no mRNA surveillance pathway Base excision repair 0 0.491106719 0.487001287 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Base excision repair 0 0.488142292 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Base excision repair 0.686086957 0.635375494 0.637323037 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Base excision repair 0 -0.463438735 -0.467438867 kegg kegg NA NA no no no no no no Nitrogen metabolism Base excision repair 0 0 -0.497812098 kegg kegg NA NA no no no no no no One carbon pool by folate Base excision repair 0.688695652 0.789525692 0.724324324 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Base excision repair 0.6 0.716403162 0.648133848 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Base excision repair 0 0.518774704 0.586872587 kegg kegg NA NA no no no no no no Pentose phosphate pathway Base excision repair -0.526086957 -0.678853755 -0.495238095 kegg kegg NA NA no no no no no no Platinum drug resistance Base excision repair 0.837391304 0.723320158 0.636036036 kegg kegg NA NA no no no no no no PPAR signaling pathway Base excision repair 0 -0.499011858 -0.645559846 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Base excision repair 0.519130435 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Base excision repair 0.450434783 0 0.704247104 kegg kegg NA NA no no no no no no Protein export Base excision repair 0.575652174 0 0.469240669 kegg kegg NA NA no no no no no no Purine metabolism Base excision repair 0 0.52173913 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Base excision repair 0 0.66798419 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Base excision repair 0.519130435 0.449604743 0.695238095 kegg kegg NA NA no no no no no no Retinol metabolism Base excision repair 0 0.695652174 0.691377091 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Base excision repair 0.884347826 0.813241107 0.789189189 kegg kegg NA NA no no no no no no RNA degradation Base excision repair 0 0.491106719 0.564221364 kegg kegg NA NA no no no no no no RNA polymerase Base excision repair 0.773913043 0.709486166 0.762419562 kegg kegg NA NA no no no no no no RNA transport Base excision repair 0.651304348 0 0.414414414 kegg kegg NA NA no no no no no no Selenocompound metabolism Base excision repair 0.766086957 0.799407115 0.75984556 kegg kegg NA NA no no no no no no Sphingolipid metabolism Base excision repair -0.64 0 0 kegg kegg NA NA no no no no no no Spliceosome Base excision repair 0.880869565 0.757905138 0.679021879 kegg kegg NA NA no no no no no no Steroid biosynthesis Base excision repair 0 0.438735178 0.720978121 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Base excision repair 0 0 0.412612613 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Base excision repair 0.584347826 0.731225296 0.752123552 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Base excision repair 0.437391304 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Base excision repair 0.635652174 0.593873518 0.614671815 kegg kegg NA NA no no no no no no Tryptophan metabolism Base excision repair 0 0 0.584041184 kegg kegg NA NA no up no no no no Tyrosine metabolism Base excision repair 0 0.492094862 0.527927928 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Base excision repair 0 0.712450593 0.728442728 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Base excision repair 0.52173913 0.570158103 0.763449163 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Base excision repair 0.646956522 0.68972332 0.632432432 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism beta-Alanine metabolism 0.527826087 0.592885375 0.505791506 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) beta-Alanine metabolism 0.717391304 0.719367589 0.567824968 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism beta-Alanine metabolism 0 0.622529644 0.46023166 kegg kegg NA NA no no no no no no Fatty acid degradation beta-Alanine metabolism 0.555652174 0 0.575032175 kegg kegg NA NA no no no no no no Fatty acid elongation beta-Alanine metabolism 0.82173913 0.847826087 0.795109395 kegg kegg NA NA no no no no no no Fructose and mannose metabolism beta-Alanine metabolism 0.805217391 0 0 kegg kegg NA NA no no no no no no Galactose metabolism beta-Alanine metabolism 0.857391304 0 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis beta-Alanine metabolism 0.848695652 0.681818182 0.845302445 kegg kegg NA NA no no no no no no Histidine metabolism beta-Alanine metabolism 0.723478261 0.703557312 0.763706564 kegg kegg NA NA no no no no no no Oxidative phosphorylation beta-Alanine metabolism -0.693043478 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions beta-Alanine metabolism 0.535652174 0.574110672 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway beta-Alanine metabolism 0.431304348 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism beta-Alanine metabolism 0.757391304 0.773715415 0.512226512 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis beta-Alanine metabolism 0.716521739 0.750988142 0.743114543 kegg kegg NA NA no no no no no no Pyrimidine metabolism beta-Alanine metabolism 0.793913043 0.422924901 0 kegg kegg NA NA no no no no no no Steroid biosynthesis beta-Alanine metabolism 0 0.646245059 0.453024453 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis beta-Alanine metabolism 0.63826087 0.772727273 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies beta-Alanine metabolism 0.467826087 0.468379447 0.463835264 kegg kegg NA NA no no no no no no Tryptophan metabolism beta-Alanine metabolism 0.899130435 0.90513834 0.751351351 kegg kegg NA NA no up no no no no Tyrosine metabolism beta-Alanine metabolism 0.74173913 0.73715415 0.803603604 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis beta-Alanine metabolism 0.733043478 0.668972332 0.416988417 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" beta-Alanine metabolism 0.780869565 0.725296443 0.774259974 kegg kegg NA NA no no no no no no 14:0-LPC+blood Betaine+blood 0 0 -0.489230769 serum_phospholipids serum_choline 0.00689 0.857 up up no no no no 14:0/16:0-PC+blood Betaine+blood 0 -0.509803922 -0.526837607 serum_phospholipids serum_choline 0.0358 0.857 no up no no no no 14:0/18:0-PC+blood Betaine+blood 0 -0.536764706 -0.652649573 serum_phospholipids serum_choline 0.00289 0.857 up up no no no no 14:0/18:2-PC+blood Betaine+blood -0.497744361 0 -0.445470085 serum_phospholipids serum_choline 0.102 0.857 no up no no no no 14:0/20:4-PC+blood Betaine+blood -0.511278195 0 0 serum_phospholipids serum_choline 0.486 0.857 no no no no no no 14:0+blood Betaine+blood 0 0 -0.45982906 yes serum_fattyacid serum_choline 0.00572 0.857 up no dn no no no 16:0-LPC+blood Betaine+blood 0 0.580882353 0 serum_phospholipids serum_choline 0.00456 0.857 up up no no no no 16:0/16:0-PI+blood Betaine+blood 0 0 -0.493333333 serum_phospholipids serum_choline 0.358 0.857 no no no no no no 16:0/16:1-PC+blood Betaine+blood 0 -0.595588235 -0.688205128 serum_phospholipids serum_choline 0.00283 0.857 up up no no no no 16:0/16:1-PI+blood Betaine+blood 0 0 -0.556239316 serum_phospholipids serum_choline 0.262 0.857 no no no no no no 16:0/18:2-PI+blood Betaine+blood 0 0 -0.451623932 serum_phospholipids serum_choline 0.269 0.857 no no no no no no 16:0/18:3-PC+blood Betaine+blood 0 0 -0.530940171 serum_phospholipids serum_choline 0.00216 0.857 no up up no no no 16:0/20:4-PI+blood Betaine+blood 0 0 -0.512478632 serum_phospholipids serum_choline 0.558 0.857 no no no no no no 16:0/20:5-PC+blood Betaine+blood -0.672180451 0 0 serum_phospholipids serum_choline 0.628 0.857 no no no no no no 16:0/22:0-PE+blood Betaine+blood 0 0 0.420854701 serum_phospholipids serum_choline 0.00839 0.857 dn no up no no no 16:0+blood Betaine+blood 0 0 -0.530940171 yes serum_fattyacid serum_choline 0.00876 0.857 up no no no no no 16:1-LPC+blood Betaine+blood 0 0 -0.490598291 serum_phospholipids serum_choline 0.0241 0.857 no up no no no no 16:1/18:1-PG+blood Betaine+blood 0.448120301 0 0 serum_phospholipids serum_choline 3.21E-05 0.857 no up up no no no 16:1/18:2-PG+blood Betaine+blood 0.45112782 0 0 serum_phospholipids serum_choline 1.40E-08 0.857 no up up no no no 16:1+blood Betaine+blood 0 0 -0.444102564 yes serum_fattyacid serum_choline 0.0186 0.857 no no dn no no no 18:0-LPC+blood Betaine+blood 0 0 0.42017094 serum_phospholipids serum_choline 0.554 0.857 no no no no no no 18:0/18:0-PC+blood Betaine+blood 0 -0.602941176 0 serum_phospholipids serum_choline 0.426 0.857 no no no no no no 18:0/18:1-PC+blood Betaine+blood 0 -0.637254902 0 serum_phospholipids serum_choline 0.393 0.857 no no no no no no 18:0/18:1-PG+blood Betaine+blood 0 0 -0.494017094 serum_phospholipids serum_choline 0.000842 0.857 no up no no no no 18:0/20:2-PC+blood Betaine+blood 0 -0.490196078 0.406495726 serum_phospholipids serum_choline 0.733 0.857 no no no no no no 18:0/20:3-PC+blood Betaine+blood 0 -0.661764706 0 serum_phospholipids serum_choline 0.0682 0.857 no up no no no no 18:0/20:5-PC+blood Betaine+blood 0 0 0.405128205 serum_phospholipids serum_choline 0.17 0.857 no no no no no no 18:1-LPC+blood Betaine+blood 0 0 0.450940171 serum_phospholipids serum_choline 0.179 0.857 no no no no no no 18:1/16:1-PE+blood Betaine+blood 0 -0.490196078 -0.413333333 serum_phospholipids serum_choline 0.000184 0.857 up up no no no no 18:1/18:0-PE+blood Betaine+blood 0 0 -0.448205128 serum_phospholipids serum_choline 1.39E-06 0.857 up up no no no no 18:1/18:1-PE+blood Betaine+blood 0 -0.551470588 -0.422905983 serum_phospholipids serum_choline 1.03E-05 0.857 up up no no no no 18:1/18:1-PG+blood Betaine+blood 0 -0.62745098 0 serum_phospholipids serum_choline 0.00352 0.857 no up up no no no 18:2-LPC+blood Betaine+blood 0 0.593137255 0 serum_phospholipids serum_choline 0.00743 0.857 dn no up no no no 18:3/16:0-PE+blood Betaine+blood 0 0 -0.617777778 serum_phospholipids serum_choline 0.00149 0.857 up up no no no no 18:3n3+blood Betaine+blood 0 0.485294118 0 serum_fattyacid serum_choline 0.291 0.857 no no no no no no 18:3n6+blood Betaine+blood -0.511278195 0 0 serum_fattyacid serum_choline 0.0463 0.857 up no dn no no no 20:1-LPC+blood Betaine+blood 0 0 0.655384615 serum_phospholipids serum_choline 0.217 0.857 no no no no no no 20:2/18:0-PC+blood Betaine+blood 0 -0.671568627 0 serum_phospholipids serum_choline 0.0427 0.857 no up no no no no 20:2/18:1-PE+blood Betaine+blood 0 -0.649509804 -0.437264957 serum_phospholipids serum_choline 0.00208 0.857 up up no no no no 20:2+blood Betaine+blood 0 0 0.413333333 serum_fattyacid serum_choline 0.478 0.857 no no no no no no 20:3n6+blood Betaine+blood 0 -0.549019608 0 serum_fattyacid serum_choline 0.0884 0.857 up no no no no no 20:4-LPC+blood Betaine+blood 0 0.654411765 0 serum_phospholipids serum_choline 0.949 0.857 no no no no no no 20:5-LPC+blood Betaine+blood -0.652631579 0 0 serum_phospholipids serum_choline 0.558 0.857 no no no no no no 20:5n3+blood Betaine+blood -0.685714286 0 0 serum_fattyacid serum_choline 0.988 0.857 no no no no no no 8-HETE+blood Betaine+blood 0 0.519607843 0 serum_ARA serum_choline 0.741 0.857 no no no no no no "9,10-EPOME+blood" Betaine+blood -0.456326732 0 0 serum_ARA serum_choline 0.801 0.857 no no no no no no AA+blood Betaine+blood 0 0.529411765 0.444102564 serum_ARA serum_choline 0.212 0.857 no no no no no no Adrenergic signaling in cardiomyocytes Betaine+blood 0 0 -0.566923077 kegg serum_choline NA 0.857 no no up no no no Aldosterone synthesis and secretion Betaine+blood 0 0 -0.477692308 kegg serum_choline NA 0.857 no up up no no no Alistipes Betaine+blood 0 -0.497854171 0 Genus serum_choline 0.0114 0.857 no up no no no no Alzheimer disease Betaine+blood 0 0 -0.412307692 kegg serum_choline NA 0.857 no no no no no no Amphetamine addiction Betaine+blood 0 0 -0.568461538 kegg serum_choline NA 0.857 no no no no no no Apoptosis Betaine+blood 0 0 0.433846154 kegg serum_choline NA 0.857 no no no no no no Biosynthesis of amino acids Betaine+blood 0 0 0.493846154 kegg serum_choline NA 0.857 no no no no no no Calcium signaling pathway Betaine+blood 0 0 -0.453076923 kegg serum_choline NA 0.857 no up up no no no Carbon metabolism Betaine+blood 0 0 0.486153846 kegg serum_choline NA 0.857 no no no no no no Cocaine addiction Betaine+blood 0 0 -0.420769231 kegg serum_choline NA 0.857 no no no no no no Complement and coagulation cascades Betaine+blood 0 0 0.409230769 kegg serum_choline NA 0.857 no no no no no no Coprococcus Betaine+blood -0.545864662 0 0.455726496 butyrate-producing Genus serum_choline 0.612 0.857 no no no no no no Cushing syndrome Betaine+blood 0 0 -0.426923077 kegg serum_choline NA 0.857 no no up no no no Dopaminergic synapse Betaine+blood 0 0 -0.551538462 kegg serum_choline NA 0.857 no up no no no no EGFR tyrosine kinase inhibitor resistance Betaine+blood 0 0 -0.416153846 kegg serum_choline NA 0.857 no no no no no no Fc epsilon RI signaling pathway Betaine+blood 0 0 0.473846154 kegg serum_choline NA 0.857 no no no no no no Fc gamma R-mediated phagocytosis Betaine+blood 0 0 0.436153846 kegg serum_choline NA 0.857 no no no no no no Fluid shear stress and atherosclerosis Betaine+blood 0 0 0.422307692 kegg serum_choline NA 0.857 no no no no no no Glucagon signaling pathway Betaine+blood 0 0 -0.538461538 kegg serum_choline NA 0.857 no no no no no no GnRH signaling pathway Betaine+blood 0 0 -0.512307692 kegg serum_choline NA 0.857 no no no no no no Inflammatory mediator regulation of TRP channels Betaine+blood 0 0 -0.453076923 kegg serum_choline NA 0.857 no no no no no no Long-term potentiation Betaine+blood 0 0 -0.414615385 kegg serum_choline NA 0.857 no no up no no no Lysosome Betaine+blood 0 0 0.500769231 kegg serum_choline NA 0.857 no no no no no no Melanogenesis Betaine+blood 0 0 -0.516923077 kegg serum_choline NA 0.857 no no no no no no mRNA surveillance pathway Betaine+blood 0 0 -0.403846154 kegg serum_choline NA 0.857 no no no no no no Neuroactive ligand-receptor interaction Betaine+blood 0 0 0.420769231 kegg serum_choline NA 0.857 up up up no no no Non-alcoholic fatty liver disease Betaine+blood 0 0 -0.442307692 kegg serum_choline NA 0.857 no no no no no no Paraprevotella Betaine+blood 0 0 0.408895201 Genus serum_choline 0.118 0.857 no no no no no no "Parathyroid hormone synthesis, secretion and action" Betaine+blood 0 0 -0.475384615 kegg serum_choline NA 0.857 no no no no no no Pathogenic Escherichia coli infection Betaine+blood 0 0 0.462307692 kegg serum_choline NA 0.857 no no no no no no Protein processing in endoplasmic reticulum Betaine+blood 0 0 -0.451538462 kegg serum_choline NA 0.857 no no no no no no Salmonella infection Betaine+blood 0 0 0.424615385 kegg serum_choline NA 0.857 no no no no no no Tuberculosis Betaine+blood 0 0 0.504615385 kegg serum_choline NA 0.857 no no dn no no no Vascular smooth muscle contraction Betaine+blood 0 0 -0.487692308 kegg serum_choline NA 0.857 no no no no no no 2-Oxocarboxylic acid metabolism Bile secretion 0 0 -0.622908623 kegg kegg NA NA no no no no no no ABC transporters Bile secretion -0.615652174 0 -0.428056628 kegg kegg NA NA no up up no no no Adipocytokine signaling pathway Bile secretion 0 0 0.575804376 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Bile secretion 0.715652174 0.57312253 0.404890605 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Bile secretion -0.464347826 0 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Bile secretion 0.806956522 0.66798419 0.525096525 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Bile secretion -0.524347826 0 -0.569111969 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Bile secretion -0.493043478 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Bile secretion 0 0 0.672844273 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Bile secretion 0 0.587944664 0.416988417 kegg kegg NA NA no no no no no no Arginine and proline metabolism Bile secretion -0.460869565 0 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Bile secretion -0.42173913 0 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Bile secretion 0 0 -0.718404118 kegg kegg NA NA no no no no no no Autophagy - other Bile secretion 0 -0.511857708 -0.407722008 kegg kegg NA NA no no no no no no Base excision repair Bile secretion -0.473043478 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Bile secretion -0.409565217 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Bile secretion 0 0 0.581209781 kegg kegg NA NA no no no no no no Butanoate metabolism Bile secretion -0.417391304 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Bile secretion 0.583478261 0.703557312 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Bile secretion 0.503478261 0 0.496782497 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Bile secretion 0 0 -0.508108108 kegg kegg NA NA no no no no no no Cardiac muscle contraction Bile secretion 0.467826087 0.488142292 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Bile secretion 0 -0.47826087 0 kegg kegg NA NA no no no no no no Cholinergic synapse Bile secretion 0 0 -0.432947233 kegg kegg NA NA no no no no no no Circadian entrainment Bile secretion 0.766086957 0.729249012 0.778893179 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Bile secretion 0 0 -0.614414414 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Bile secretion 0.824347826 0.730237154 0.728442728 kegg kegg NA NA no no up no no no Cushing syndrome Bile secretion 0.746956522 0.590909091 0.470527671 kegg kegg NA NA no no up no no no DNA replication Bile secretion -0.428695652 0 -0.467696268 kegg kegg NA NA no no no no no no Dopaminergic synapse Bile secretion 0.708695652 0.732213439 0.46975547 kegg kegg NA NA no up no no no no Drug metabolism - other enzymes Bile secretion 0 0 -0.63963964 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Bile secretion 0.897391304 0.82312253 0.81003861 kegg kegg NA NA no no no no no no Endocrine resistance Bile secretion 0.709565217 0.70256917 0.699099099 kegg kegg NA NA no no no no no no Estrogen signaling pathway Bile secretion 0 0 0.497554698 kegg kegg NA NA no no no no no no Fanconi anemia pathway Bile secretion -0.427826087 0 -0.433204633 kegg kegg NA NA no no no no no no Fat digestion and absorption Bile secretion 0 0 -0.42960103 yes kegg kegg NA NA no up up no no no Fatty acid degradation Bile secretion -0.608695652 -0.499011858 -0.460746461 kegg kegg NA NA no no no no no no Fatty acid metabolism Bile secretion -0.619130435 -0.458498024 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Bile secretion -0.407826087 0 0 kegg kegg NA NA no no no no no no Ferroptosis Bile secretion 0.619130435 0.514822134 0.603346203 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Bile secretion -0.423478261 0 -0.422908623 kegg kegg NA NA no no no no no no Galactose metabolism Bile secretion -0.482608696 -0.420948617 -0.647876448 kegg kegg NA NA no no no no no no Gap junction Bile secretion 0.859130435 0.750988142 0.877477477 kegg kegg NA NA no no no no no no Gastric acid secretion Bile secretion 0.6 0.599802372 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Bile secretion 0.611304348 0.579051383 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Bile secretion 0.717391304 0.460474308 0.851222651 kegg kegg NA NA no up up no no no Glutathione metabolism Bile secretion 0 0.517786561 0.598198198 kegg kegg NA NA no no no no no no Glycerolipid metabolism Bile secretion -0.50173913 0 -0.701930502 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Bile secretion 0 0 -0.61956242 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Bile secretion 0 0 0.61003861 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Bile secretion 0 0 -0.436808237 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Bile secretion 0 0 -0.680566281 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Bile secretion 0.439130435 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Bile secretion 0 0 -0.735392535 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Bile secretion -0.604347826 0 0 kegg kegg NA NA no no no no no no GnRH secretion Bile secretion 0 0 -0.484427284 kegg kegg NA NA no up up no no no GnRH signaling pathway Bile secretion 0.755652174 0.734189723 0.615958816 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Bile secretion 0.437391304 0.432806324 0.517631918 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Bile secretion 0 0 -0.487258687 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Bile secretion 0 0 -0.581209781 kegg kegg NA NA no no no no no no Histidine metabolism Bile secretion -0.476521739 0 -0.48030888 kegg kegg NA NA no no no no no no Homologous recombination Bile secretion -0.433043478 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Bile secretion 0.753913043 0.660079051 0.565508366 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Bile secretion -0.434782609 0 -0.550579151 kegg kegg NA NA no no no no no no Insulin secretion Bile secretion 0.749565217 0.710474308 0.67027027 yes kegg kegg NA NA no up up no no no Long-term depression Bile secretion 0.909565217 0.742094862 0.866409266 kegg kegg NA NA no no no no no no Longevity regulating pathway Bile secretion 0 0 0.598455598 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Bile secretion 0 -0.621541502 0 kegg kegg NA NA no no no no no no Lysine degradation Bile secretion 0 0 -0.531016731 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Bile secretion 0 0 -0.50990991 kegg kegg NA NA no no no no no no MAPK signaling pathway Bile secretion 0 -0.536561265 -0.608236808 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Bile secretion 0 0 -0.492664093 kegg kegg NA NA no up no no no no Melanogenesis Bile secretion 0.808695652 0.684782609 0.625740026 kegg kegg NA NA no no no no no no Mismatch repair Bile secretion -0.44173913 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Bile secretion 0.586086957 0.562252964 0.511196911 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Bile secretion 0 -0.62944664 0 kegg kegg NA NA no no no no no no Necroptosis Bile secretion 0.664347826 0.51284585 0.631402831 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Bile secretion 0 -0.425889328 0 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Bile secretion -0.611304348 0 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Bile secretion -0.448695652 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Bile secretion -0.56173913 -0.507905138 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Bile secretion 0.482608696 0.513833992 0 kegg kegg NA NA no no no no no no Notch signaling pathway Bile secretion 0 0 -0.654568855 kegg kegg NA NA no no no no no no Nucleotide excision repair Bile secretion -0.436521739 0 0 kegg kegg NA NA no no no no no no One carbon pool by folate Bile secretion 0 0 -0.458429858 kegg kegg NA NA no no no no no no Osteoclast differentiation Bile secretion -0.453913043 -0.447628458 0 kegg kegg NA NA no no no no no no Other glycan degradation Bile secretion -0.585217391 -0.416996047 -0.699099099 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Bile secretion 0 0 -0.484169884 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Bile secretion 0.852173913 0.909090909 0.932818533 kegg kegg NA NA no up up no no no Oxidative phosphorylation Bile secretion 0.427826087 0.489130435 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Bile secretion 0 0.450592885 0.404633205 kegg kegg NA NA no no no no no no Pancreatic secretion Bile secretion 0.900869565 0.807312253 0.805920206 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Bile secretion 0.594782609 0.621541502 0.491891892 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Bile secretion 0 0 -0.517117117 kegg kegg NA NA no no no no no no Peroxisome Bile secretion -0.622608696 -0.489130435 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Bile secretion 0 0 -0.465122265 kegg kegg NA NA no no no no no no Platelet activation Bile secretion 0.508695652 0.5256917 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Bile secretion 0 0 0.602574003 kegg kegg NA NA no no no no no no PPAR signaling pathway Bile secretion 0 -0.519762846 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Bile secretion -0.450434783 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Bile secretion 0 0 -0.517117117 kegg kegg NA NA no no no no no no Proteasome Bile secretion 0 0 -0.570913771 kegg kegg NA NA no no no no no no Protein digestion and absorption Bile secretion -0.62173913 -0.603754941 0 yes kegg kegg NA NA no up up no no no Purine metabolism Bile secretion 0 0 0.412870013 kegg kegg NA NA no no no no no no Pyrimidine metabolism Bile secretion -0.508695652 0 -0.470785071 kegg kegg NA NA no no no no no no Rap1 signaling pathway Bile secretion 0.473043478 0.501976285 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Bile secretion 0.911304348 0.914031621 0.882882883 kegg kegg NA NA no no no no no no Relaxin signaling pathway Bile secretion 0.431304348 0 0.483140283 kegg kegg NA NA no no no no no no Renin secretion Bile secretion 0.76173913 0.68083004 0.843500644 kegg kegg NA NA no no no no no no Retinol metabolism Bile secretion 0 0 -0.544916345 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Bile secretion 0 0.499011858 0 kegg kegg NA NA no no up no no no Ribosome biogenesis in eukaryotes Bile secretion 0 0 -0.42033462 kegg kegg NA NA no no no no no no RNA degradation Bile secretion 0 0 -0.493693694 kegg kegg NA NA no no no no no no RNA transport Bile secretion -0.426956522 0 0 kegg kegg NA NA no no no no no no Salivary secretion Bile secretion 0.72173913 0.616600791 0.73024453 kegg kegg NA NA no no no no no no Selenocompound metabolism Bile secretion 0 0 -0.562676963 kegg kegg NA NA no no no no no no Serotonergic synapse Bile secretion 0.611304348 0.659090909 0.697812098 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Bile secretion -0.706956522 -0.529644269 -0.423423423 kegg kegg NA NA no no no no no no Sphingolipid metabolism Bile secretion 0 0 -0.523294723 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Bile secretion 0 -0.41798419 -0.428571429 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Bile secretion 0 0 -0.515572716 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Bile secretion 0 0 -0.585842986 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Bile secretion 0 -0.631422925 0 kegg kegg NA NA no no no no no no Taste transduction Bile secretion 0 0 -0.599485199 kegg kegg NA NA no no up no no no Terpenoid backbone biosynthesis Bile secretion 0 0 -0.483912484 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Bile secretion 0 -0.544466403 -0.50990991 kegg kegg NA NA no no no no no no Th17 cell differentiation Bile secretion 0 -0.635375494 -0.494208494 kegg kegg NA NA no no no no no no Thermogenesis Bile secretion 0.497391304 0.463438735 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Bile secretion 0 0.518774704 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Bile secretion 0.643478261 0.81027668 0.773745174 kegg kegg NA NA no no no no no no Tryptophan metabolism Bile secretion -0.467826087 0 -0.463835264 kegg kegg NA NA no up no no no no Type II diabetes mellitus Bile secretion 0 0 -0.487516088 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Bile secretion -0.444347826 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Bile secretion 0.566956522 0.543478261 0.494723295 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Bile secretion -0.468695652 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Bile secretion 0 0 -0.402831403 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Bile secretion 0.703478261 0.650197628 0.62007722 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Bile secretion 0.910434783 0.865612648 0.816216216 kegg kegg NA NA no no no no no no VEGF signaling pathway Bile secretion 0 0 -0.475675676 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Bile secretion 0 0 0.429343629 kegg kegg NA NA no no no no no no Wnt signaling pathway Bile secretion 0 0 -0.492664093 kegg kegg NA NA no no no no no no Turicibacter Bilophila 0 0.576532599 0 Genus Genus 0.269 0.528 no no no no no no 2-Oxocarboxylic acid metabolism Biosynthesis of amino acids 0.593043478 -0.5 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Biosynthesis of amino acids 0.410434783 0.717391304 0.679279279 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Biosynthesis of amino acids 0.754782609 0.5 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Biosynthesis of amino acids 0.640869565 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Biosynthesis of amino acids 0 -0.464426877 -0.450965251 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Biosynthesis of amino acids 0 0 0.441698842 kegg kegg NA NA no no no no no no Arginine and proline metabolism Biosynthesis of amino acids 0.410434783 0.685770751 0.493436293 kegg kegg NA NA no up no no no no Arginine biosynthesis Biosynthesis of amino acids 0.492173913 0.773715415 0.764221364 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Biosynthesis of amino acids 0 -0.437747036 0 kegg kegg NA NA no no no no no no Bacteroides Biosynthesis of amino acids 0.423478261 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no beta-Alanine metabolism Biosynthesis of amino acids 0.763478261 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Biosynthesis of amino acids 0.57826087 -0.42687747 0 kegg kegg NA NA no no no no no no Carbon metabolism Biosynthesis of amino acids 0.913913043 0.524703557 0.864607465 kegg kegg NA NA no no no no no no Coprococcus Biosynthesis of amino acids 0 0 0.410322415 butyrate-producing Genus kegg 0.612 NA no no no no no no Drug metabolism - cytochrome P450 Biosynthesis of amino acids 0 -0.496047431 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Biosynthesis of amino acids 0.711304348 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Biosynthesis of amino acids -0.704347826 -0.7243083 -0.544401544 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Biosynthesis of amino acids 0 0.759881423 0.475675676 kegg kegg NA NA no no no no no no Fatty acid degradation Biosynthesis of amino acids 0.642608696 0.674901186 0.46023166 kegg kegg NA NA no no no no no no Fatty acid elongation Biosynthesis of amino acids 0.607826087 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Biosynthesis of amino acids 0.704347826 0.747035573 0.498841699 kegg kegg NA NA no no no no no no Folate biosynthesis Biosynthesis of amino acids 0 -0.572134387 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Biosynthesis of amino acids 0.773043478 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Biosynthesis of amino acids 0.728695652 0.492094862 0 kegg kegg NA NA no no no no no no Glutathione metabolism Biosynthesis of amino acids 0 -0.504940711 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Biosynthesis of amino acids 0 0 -0.480823681 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Biosynthesis of amino acids 0 0 -0.627027027 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Biosynthesis of amino acids 0 -0.451581028 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Biosynthesis of amino acids 0.786956522 0 0.51994852 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Biosynthesis of amino acids 0 0.414031621 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Biosynthesis of amino acids 0.493043478 -0.446640316 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Biosynthesis of amino acids -0.513043478 -0.520750988 -0.607979408 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Biosynthesis of amino acids 0 0.498023715 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Biosynthesis of amino acids -0.463478261 0 -0.435778636 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Biosynthesis of amino acids 0 -0.497035573 -0.438610039 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Biosynthesis of amino acids 0.584347826 0.81027668 0.789446589 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Biosynthesis of amino acids 0 0 -0.514800515 kegg kegg NA NA no no no no no no Lysine degradation Biosynthesis of amino acids 0 -0.606719368 -0.741570142 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Biosynthesis of amino acids -0.576521739 -0.613636364 -0.750579151 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Biosynthesis of amino acids 0 -0.755928854 -0.62033462 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Biosynthesis of amino acids 0.467826087 0.765810277 0.696010296 kegg kegg NA NA no no no no no no Nitrogen metabolism Biosynthesis of amino acids 0.52173913 0.7243083 0.62033462 kegg kegg NA NA no no no no no no One carbon pool by folate Biosynthesis of amino acids 0 -0.639328063 -0.6002574 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Biosynthesis of amino acids -0.566956522 -0.645256917 -0.71969112 kegg kegg NA NA no no no no no no Oxidative phosphorylation Biosynthesis of amino acids -0.774782609 -0.632411067 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Biosynthesis of amino acids 0 0.696640316 0.673616474 kegg kegg NA NA no no dn no no no Parabacteroides Biosynthesis of amino acids 0.480869565 0 0 Genus kegg 4.19E-05 NA no up up no no no Paraprevotella Biosynthesis of amino acids 0 -0.48656192 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Biosynthesis of amino acids 0 -0.638339921 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Biosynthesis of amino acids 0.770434783 0.886363636 0.883655084 kegg kegg NA NA no no no no no no Phenylalanine metabolism Biosynthesis of amino acids 0.446956522 0 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Biosynthesis of amino acids 0 -0.419960474 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Biosynthesis of amino acids 0 0 0.413384813 kegg kegg NA NA no no no no no no Purine metabolism Biosynthesis of amino acids 0 -0.537549407 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Biosynthesis of amino acids 0.610434783 -0.515810277 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Biosynthesis of amino acids 0 -0.468379447 0 kegg kegg NA NA no no no no no no Retinol metabolism Biosynthesis of amino acids 0.537391304 0 0 kegg kegg NA NA no no no no no no Ruminococcus Biosynthesis of amino acids -0.419130435 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Selenocompound metabolism Biosynthesis of amino acids 0 0 -0.503217503 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Biosynthesis of amino acids 0.653043478 0.692687747 0.450965251 kegg kegg NA NA no no no no no no Steroid biosynthesis Biosynthesis of amino acids -0.41826087 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Biosynthesis of amino acids 0 0 0.514543115 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Biosynthesis of amino acids 0 -0.458498024 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Biosynthesis of amino acids 0 0 -0.511969112 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Biosynthesis of amino acids 0 0 -0.467438867 kegg kegg NA NA no no no no no no Tryptophan metabolism Biosynthesis of amino acids 0.567826087 0 0 kegg kegg NA NA no up no no no no Ubiquinone and other terpenoid-quinone biosynthesis Biosynthesis of amino acids 0 0 -0.416988417 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Biosynthesis of amino acids 0 -0.467391304 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Biosynthesis of amino acids 0 -0.610671937 -0.474646075 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Biosynthesis of cofactors 0.555652174 0 -0.413384813 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Biosynthesis of cofactors 0.429565217 0.444664032 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Biosynthesis of cofactors 0.431304348 0.48715415 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Biosynthesis of cofactors 0.473043478 0 0.685199485 kegg kegg NA NA no no no no no no Arginine and proline metabolism Biosynthesis of cofactors 0 -0.464426877 0 kegg kegg NA NA no up no no no no Ascorbate and aldarate metabolism Biosynthesis of cofactors 0 0 -0.425482625 kegg kegg NA NA no no no no no no beta-Alanine metabolism Biosynthesis of cofactors 0.453043478 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Biosynthesis of cofactors 0 -0.553359684 0 kegg kegg NA NA no no no no no no Butanoate metabolism Biosynthesis of cofactors 0.613913043 0.527667984 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Biosynthesis of cofactors 0.475652174 0.489130435 -0.427541828 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Biosynthesis of cofactors 0 0.527667984 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Biosynthesis of cofactors 0 0.515810277 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Biosynthesis of cofactors 0 0.699604743 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Biosynthesis of cofactors -0.460869565 -0.489130435 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Biosynthesis of cofactors 0.491304348 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Biosynthesis of cofactors 0 -0.446640316 0 kegg kegg NA NA no no no no no no Glutathione metabolism Biosynthesis of cofactors 0.555652174 0.678853755 0.801801802 kegg kegg NA NA no no no no no no Glycerolipid metabolism Biosynthesis of cofactors 0 0 -0.428314028 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Biosynthesis of cofactors 0.91826087 0.924901186 0.984813385 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Biosynthesis of cofactors 0.475652174 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Biosynthesis of cofactors 0 -0.451581028 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Biosynthesis of cofactors 0.47826087 0 -0.511711712 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Biosynthesis of cofactors -0.410434783 -0.663043478 -0.579407979 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Biosynthesis of cofactors 0 0.678853755 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Biosynthesis of cofactors 0 -0.438735178 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Biosynthesis of cofactors 0 0.550395257 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Biosynthesis of cofactors -0.436521739 -0.576086957 0 kegg kegg NA NA no no no no no no One carbon pool by folate Biosynthesis of cofactors 0 0.718379447 0 kegg kegg NA NA no no no no no no Other glycan degradation Biosynthesis of cofactors 0 0 -0.520720721 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Biosynthesis of cofactors 0 0.445652174 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Biosynthesis of cofactors -0.540869565 -0.48715415 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Biosynthesis of cofactors 0.420869565 0.513833992 -0.445045045 kegg kegg NA NA no no no no no no Pentose phosphate pathway Biosynthesis of cofactors 0 -0.675889328 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Biosynthesis of cofactors 0.571304348 0 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Biosynthesis of cofactors 0.871304348 0.875494071 0.980694981 kegg kegg NA NA no no no no no no Propanoate metabolism Biosynthesis of cofactors 0 0.507905138 0 kegg kegg NA NA no no no no no no Purine metabolism Biosynthesis of cofactors 0.595652174 0.87055336 0.546203346 kegg kegg NA NA no no no no no no Pyrimidine metabolism Biosynthesis of cofactors 0 0.68083004 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Biosynthesis of cofactors 0.447826087 0.631422925 0 kegg kegg NA NA no no no no no no Retinol metabolism Biosynthesis of cofactors 0 0.541501976 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Biosynthesis of cofactors 0 0.506916996 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Biosynthesis of cofactors 0 0 -0.43037323 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Biosynthesis of cofactors 0 -0.48715415 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Biosynthesis of cofactors 0 0.498023715 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Biosynthesis of cofactors 0 0.463438735 0 kegg kegg NA NA no no no no no no Sulfur metabolism Biosynthesis of cofactors 0.626086957 0.653162055 0.744658945 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Biosynthesis of cofactors 0 0.7243083 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Biosynthesis of cofactors 0 0.438735178 0 kegg kegg NA NA no no no no no no Thiamine metabolism Biosynthesis of cofactors 0 0.712450593 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Biosynthesis of cofactors 0.465217391 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Biosynthesis of cofactors 0.491304348 0.616600791 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Biosynthesis of cofactors 0.492173913 0.598814229 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Biosynthesis of cofactors 0.526086957 0.544466403 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Biosynthesis of cofactors 0 0.469367589 -0.456885457 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Biosynthesis of unsaturated fatty acids 0.410434783 0 0.476447876 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Biosynthesis of unsaturated fatty acids 0.640869565 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Biosynthesis of unsaturated fatty acids 0.68 0 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Biosynthesis of unsaturated fatty acids 0.530434783 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Biosynthesis of unsaturated fatty acids 0.704347826 0.729249012 0.749034749 kegg kegg NA NA no no no no no no Butanoate metabolism Biosynthesis of unsaturated fatty acids 0.617391304 0.614624506 0.656370656 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Biosynthesis of unsaturated fatty acids 0.715652174 0.632411067 0.448648649 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Biosynthesis of unsaturated fatty acids 0.586086957 0.599802372 0.444015444 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Biosynthesis of unsaturated fatty acids 0.473913043 0.46541502 0.406177606 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Biosynthesis of unsaturated fatty acids 0.524347826 0.428853755 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Biosynthesis of unsaturated fatty acids -0.406956522 0 0 kegg kegg NA NA no no no no no no Fatty acid degradation Biosynthesis of unsaturated fatty acids 0.451304348 0 0.462033462 kegg kegg NA NA no no no no no no Fatty acid elongation Biosynthesis of unsaturated fatty acids 0.795652174 0.802371542 0.814157014 kegg kegg NA NA no no no no no no Galactose metabolism Biosynthesis of unsaturated fatty acids 0.526086957 0 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Biosynthesis of unsaturated fatty acids 0.63826087 0.497035573 0.545688546 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Biosynthesis of unsaturated fatty acids 0 -0.477272727 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Biosynthesis of unsaturated fatty acids -0.532173913 -0.554347826 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Biosynthesis of unsaturated fatty acids -0.525217391 0 -0.470785071 kegg kegg NA NA no no no no no no Histidine metabolism Biosynthesis of unsaturated fatty acids 0.573913043 0.494071146 0.511711712 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Biosynthesis of unsaturated fatty acids -0.603478261 -0.453557312 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Biosynthesis of unsaturated fatty acids 0.514782609 0.531620553 0.438610039 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Biosynthesis of unsaturated fatty acids 0.571304348 0 0 kegg kegg NA NA no no no no no no One carbon pool by folate Biosynthesis of unsaturated fatty acids 0.68173913 0.436758893 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Biosynthesis of unsaturated fatty acids 0.688695652 0.444664032 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Biosynthesis of unsaturated fatty acids 0.48173913 0.514822134 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Biosynthesis of unsaturated fatty acids 0.896521739 0.833003953 0.84967825 kegg kegg NA NA no no no no no no Propanoate metabolism Biosynthesis of unsaturated fatty acids 0.619130435 0.606719368 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Biosynthesis of unsaturated fatty acids 0.653913043 0.48715415 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Biosynthesis of unsaturated fatty acids 0.692173913 0.520750988 0.464864865 kegg kegg NA NA no no no no no no Retinol metabolism Biosynthesis of unsaturated fatty acids 0.805217391 0.711462451 0.54980695 kegg kegg NA NA no no no no no no Sphingolipid metabolism Biosynthesis of unsaturated fatty acids -0.435652174 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Biosynthesis of unsaturated fatty acids 0 0.707509881 0.569111969 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Biosynthesis of unsaturated fatty acids 0.705217391 0.671936759 0 kegg kegg NA NA no no no no no no Sulfur metabolism Biosynthesis of unsaturated fatty acids 0 0.427865613 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Biosynthesis of unsaturated fatty acids 0.686086957 0.609683794 0.610553411 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Biosynthesis of unsaturated fatty acids 0 -0.477272727 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Biosynthesis of unsaturated fatty acids 0 0.497035573 0 kegg kegg NA NA no no no no no no Thiamine metabolism Biosynthesis of unsaturated fatty acids 0.414782609 0.45256917 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Biosynthesis of unsaturated fatty acids 0.725217391 0.77173913 0.632689833 kegg kegg NA NA no up no no no no Tyrosine metabolism Biosynthesis of unsaturated fatty acids 0.743478261 0.637351779 0.707078507 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Biosynthesis of unsaturated fatty acids 0.705217391 0.656126482 0.441184041 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Biosynthesis of unsaturated fatty acids 0.733043478 0.602766798 0.74002574 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Bladder cancer 0 -0.723320158 0 kegg kegg NA NA no no no no no no Adherens junction Bladder cancer 0 -0.562252964 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Bladder cancer 0 0.559288538 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Bladder cancer 0 -0.575098814 -0.501673102 kegg kegg NA NA no no up no no no African trypanosomiasis Bladder cancer 0 0.565217391 0.422393822 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Bladder cancer 0 0.907114625 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Bladder cancer 0.631304348 0.840909091 0.533590734 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Bladder cancer -0.580869565 -0.591897233 -0.458687259 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Bladder cancer 0 0.483201581 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Bladder cancer 0 0.571146245 0 kegg kegg NA NA no no no no no no Alzheimer disease Bladder cancer 0 -0.747035573 -0.518918919 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Bladder cancer 0 -0.572134387 0 kegg kegg NA NA no no no no no no Amoebiasis Bladder cancer 0.450434783 0.914031621 0 kegg kegg NA NA no no no no no no Amphetamine addiction Bladder cancer -0.685217391 -0.714426877 -0.463320463 kegg kegg NA NA no no no no no no AMPK signaling pathway Bladder cancer -0.543478261 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Bladder cancer 0 -0.795454545 -0.536936937 kegg kegg NA NA no no no no no no Apelin signaling pathway Bladder cancer -0.42 -0.833003953 -0.485971686 kegg kegg NA NA no no no no no no Apoptosis Bladder cancer 0.553913043 0.831027668 0.587902188 kegg kegg NA NA no no no no no no Arginine and proline metabolism Bladder cancer 0.645217391 0.901185771 0.685714286 kegg kegg NA NA no up no no no no Arginine biosynthesis Bladder cancer 0.673043478 0.821146245 0.543886744 kegg kegg NA NA no no no no no no Autophagy - animal Bladder cancer 0.496521739 0.820158103 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Bladder cancer 0.423478261 0.830039526 0.536936937 kegg kegg NA NA no no no no no no Basal transcription factors Bladder cancer 0 -0.561264822 -0.475160875 kegg kegg NA NA no no no no no no Base excision repair Bladder cancer 0 -0.431818182 -0.521235521 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Bladder cancer 0.442608696 0.64229249 0.551866152 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Bladder cancer -0.666956522 -0.572134387 0 kegg kegg NA NA no no no no no no Butanoate metabolism Bladder cancer 0 -0.847826087 -0.462805663 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Bladder cancer 0.544347826 0.806324111 0.515830116 kegg kegg NA NA no no no no no no cAMP signaling pathway Bladder cancer 0 0.528656126 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Bladder cancer 0.416521739 0.551383399 0 kegg kegg NA NA no no no no no no Carbon metabolism Bladder cancer 0 0 0.461261261 kegg kegg NA NA no no no no no no Cardiac muscle contraction Bladder cancer 0 -0.726284585 -0.483140283 kegg kegg NA NA no no up no no no Cell cycle Bladder cancer -0.435652174 -0.71541502 -0.598712999 kegg kegg NA NA no no no no no no Cellular senescence Bladder cancer 0.433043478 0.548418972 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Bladder cancer 0.62173913 0.786561265 0.608751609 kegg kegg NA NA no no no no no no Chagas disease Bladder cancer 0 0.846837945 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Bladder cancer 0 0 0.616988417 kegg kegg NA NA no no no no no no Chemokine signaling pathway Bladder cancer 0.563478261 0.727272727 0.49034749 kegg kegg NA NA no no no no no no Cholesterol metabolism Bladder cancer 0 0 0.560875161 yes kegg kegg NA NA no no up no no no Circadian entrainment Bladder cancer -0.492173913 -0.463438735 0 kegg kegg NA NA no up up no no no Circadian rhythm Bladder cancer 0 -0.416996047 -0.419305019 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Bladder cancer 0 -0.845849802 0 kegg kegg NA NA no no no no no no Cocaine addiction Bladder cancer -0.534782609 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Bladder cancer 0.52 0.695652174 0.456113256 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Bladder cancer -0.519130435 -0.744071146 -0.412097812 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Bladder cancer -0.576521739 0 0 kegg kegg NA NA no no up no no no Cushing syndrome Bladder cancer -0.683478261 0 -0.408751609 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Bladder cancer 0 -0.862648221 -0.683140283 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Bladder cancer 0.433043478 0 0 kegg kegg NA NA no no no no no no DNA replication Bladder cancer 0 -0.852766798 -0.483397683 kegg kegg NA NA no no no no no no Dopaminergic synapse Bladder cancer 0 -0.488142292 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Bladder cancer 0 -0.827075099 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Bladder cancer 0 -0.815217391 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Bladder cancer -0.55826087 -0.447628458 -0.475675676 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Bladder cancer 0 -0.729249012 -0.473101673 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Bladder cancer -0.560869565 -0.553359684 0 kegg kegg NA NA no no no no no no Endocrine resistance Bladder cancer -0.463478261 0 0 kegg kegg NA NA no no no no no no Endocytosis Bladder cancer 0.48 0.457509881 0 kegg kegg NA NA no no no no no no Endometrial cancer Bladder cancer 0 0.683794466 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Bladder cancer 0.797391304 0.806324111 0.609009009 kegg kegg NA NA no no no no no no ErbB signaling pathway Bladder cancer 0 0.481225296 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Bladder cancer 0 -0.68972332 -0.479021879 kegg kegg NA NA no no no no no no Ether lipid metabolism Bladder cancer -0.422608696 -0.513833992 -0.413384813 kegg kegg NA NA no no no no no no Fanconi anemia pathway Bladder cancer 0 -0.424901186 -0.492149292 kegg kegg NA NA no no no no no no Fat digestion and absorption Bladder cancer 0.644347826 0.611660079 0.702445302 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Bladder cancer 0.72 0.83201581 0.622651223 kegg kegg NA NA no no no no no no Fatty acid degradation Bladder cancer 0.532173913 0.542490119 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Bladder cancer 0.472173913 0.524703557 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Bladder cancer 0.423478261 0.90513834 0.745173745 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Bladder cancer 0.728695652 0.619565217 0.62033462 kegg kegg NA NA no no no no no no Focal adhesion Bladder cancer 0 -0.587944664 0 kegg kegg NA NA no up up no no no Folate biosynthesis Bladder cancer 0 -0.565217391 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Bladder cancer 0.417391304 0.538537549 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Bladder cancer 0 0.53458498 0.437065637 kegg kegg NA NA no no no no no no GABAergic synapse Bladder cancer 0.582608696 0.718379447 0.465379665 kegg kegg NA NA no up up no no no Galactose metabolism Bladder cancer 0 0.529644269 0 kegg kegg NA NA no no no no no no Gap junction Bladder cancer -0.452173913 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Bladder cancer 0 -0.609683794 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Bladder cancer -0.66 -0.743083004 -0.604890605 kegg kegg NA NA no no no no no no Glutamatergic synapse Bladder cancer 0 0.532608696 0 kegg kegg NA NA no up up no no no Glutathione metabolism Bladder cancer -0.571304348 -0.612648221 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Bladder cancer 0 0.437747036 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Bladder cancer -0.673043478 -0.43083004 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Bladder cancer 0 -0.713438735 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Bladder cancer 0.773913043 0.847826087 0.527927928 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Bladder cancer 0 -0.467391304 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Bladder cancer 0.596521739 0.503952569 0.418532819 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Bladder cancer 0 -0.455533597 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Bladder cancer 0.600869565 0.826086957 0.627027027 kegg kegg NA NA no no no no no no GnRH secretion Bladder cancer 0 0.539525692 0 kegg kegg NA NA no up up no no no GnRH signaling pathway Bladder cancer -0.494782609 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Bladder cancer 0 0.48715415 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Bladder cancer 0 -0.489130435 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Bladder cancer 0 -0.442687747 0 kegg kegg NA NA no no no no no no Hepatitis B Bladder cancer 0.556521739 0.850790514 0.410810811 kegg kegg NA NA no no no no no no Hepatitis C Bladder cancer 0 0.434782609 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Bladder cancer 0 -0.719367589 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Bladder cancer 0 -0.686758893 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Bladder cancer 0.585217391 0.772727273 0.592020592 kegg kegg NA NA no no no no no no Homologous recombination Bladder cancer 0 0 -0.596396396 kegg kegg NA NA no no no no no no Human papillomavirus infection Bladder cancer 0.417391304 0.572134387 0 kegg kegg NA NA no no no no no no Huntington disease Bladder cancer 0 -0.744071146 -0.508880309 kegg kegg NA NA no no no no no no IL-17 signaling pathway Bladder cancer 0.815652174 0.736166008 0.743886744 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Bladder cancer -0.474782609 -0.717391304 -0.503474903 kegg kegg NA NA no no no no no no Insulin resistance Bladder cancer 0 0.742094862 0 kegg kegg NA NA no no no no no no Insulin secretion Bladder cancer -0.666086957 0 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Bladder cancer 0 -0.796442688 -0.44041184 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Bladder cancer 0 0.697628458 0 kegg kegg NA NA no no no no no no Legionellosis Bladder cancer 0 -0.460474308 0 kegg kegg NA NA no no no no no no Leishmaniasis Bladder cancer 0 -0.445652174 0 kegg kegg NA NA no no no no no no Long-term potentiation Bladder cancer 0 -0.681818182 0 kegg kegg NA NA no no up no no no Lysosome Bladder cancer 0.706086957 0.532608696 0.78043758 kegg kegg NA NA no no no no no no Melanogenesis Bladder cancer -0.666956522 -0.692687747 -0.533075933 kegg kegg NA NA no no no no no no Melanoma Bladder cancer 0.439130435 0.770750988 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Bladder cancer 0 -0.790513834 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Bladder cancer 0 0.804347826 0 kegg kegg NA NA no no no no no no Mismatch repair Bladder cancer 0 -0.698616601 -0.483140283 kegg kegg NA NA no no no no no no Mitophagy - animal Bladder cancer -0.507826087 -0.488142292 0 kegg kegg NA NA no no no no no no Morphine addiction Bladder cancer -0.41826087 0 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Bladder cancer 0 -0.65513834 -0.525096525 kegg kegg NA NA no no no no no no mTOR signaling pathway Bladder cancer 0 -0.718379447 -0.419305019 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Bladder cancer -0.592173913 -0.853754941 -0.522265122 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Bladder cancer 0.442608696 0.466403162 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Bladder cancer 0.473913043 0.462450593 0.694723295 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Bladder cancer 0 0.636363636 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Bladder cancer 0.700869565 0.640316206 0.652509653 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Bladder cancer 0.536521739 0.863636364 0.446589447 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Bladder cancer 0.826956522 0.914031621 0.825482625 kegg kegg NA NA no no no no no no Nitrogen metabolism Bladder cancer 0.632173913 0.822134387 0.477734878 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Bladder cancer 0.896521739 0.803359684 0.412355212 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Bladder cancer 0 -0.626482213 -0.520720721 kegg kegg NA NA no no no no no no Non-homologous end-joining Bladder cancer 0 -0.556324111 0 kegg kegg NA NA no no no no no no Notch signaling pathway Bladder cancer 0 0.486166008 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Bladder cancer 0 -0.740118577 -0.615701416 kegg kegg NA NA no no no no no no Olfactory transduction Bladder cancer 0.599130435 0.601778656 0.626769627 kegg kegg NA NA no no no no no no One carbon pool by folate Bladder cancer -0.48173913 -0.712450593 -0.519433719 kegg kegg NA NA no no no no no no Oocyte meiosis Bladder cancer 0 -0.780632411 -0.509137709 kegg kegg NA NA no no no no no no Osteoclast differentiation Bladder cancer 0.824347826 0.799407115 0.802316602 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Bladder cancer -0.590434783 0 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Bladder cancer 0 -0.733201581 -0.457400257 kegg kegg NA NA no no no no no no p53 signaling pathway Bladder cancer 0 0 -0.456113256 kegg kegg NA NA no no no no no no Pancreatic secretion Bladder cancer -0.409565217 -0.447628458 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Bladder cancer 0.786086957 0.786561265 0.598970399 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Bladder cancer 0 -0.45256917 -0.444787645 kegg kegg NA NA no no no no no no Parkinson disease Bladder cancer -0.464347826 -0.661067194 -0.425225225 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Bladder cancer 0.599130435 0.445652174 0.463063063 kegg kegg NA NA no no no no no no Pathways in cancer Bladder cancer 0 0.56916996 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Bladder cancer -0.484347826 -0.669960474 -0.424453024 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Bladder cancer 0 -0.889328063 -0.403861004 kegg kegg NA NA no no no no no no Pentose phosphate pathway Bladder cancer 0.610434783 0.639328063 0.663835264 kegg kegg NA NA no no no no no no Peroxisome Bladder cancer 0.6 0.636363636 0.433719434 kegg kegg NA NA no no no no no no Pertussis Bladder cancer 0.746956522 0.705533597 0.673873874 kegg kegg NA NA no no dn no no no Phagosome Bladder cancer 0.410434783 0.454545455 0.448648649 kegg kegg NA NA no no no no no no Phenylalanine metabolism Bladder cancer 0 -0.696640316 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Bladder cancer 0 0.865612648 0.408751609 kegg kegg NA NA no up up no no no Phototransduction Bladder cancer 0 -0.650197628 -0.541827542 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Bladder cancer 0 0 -0.537451737 yes kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism Bladder cancer -0.600869565 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Bladder cancer 0.722608696 0.719367589 0.612355212 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Bladder cancer 0 -0.488142292 0 kegg kegg NA NA no no no no no no Prion disease Bladder cancer 0 -0.815217391 -0.476190476 kegg kegg NA NA no no no no no no Prolactin signaling pathway Bladder cancer 0.434782609 0.758893281 0.421621622 kegg kegg NA NA no no no no no no Propanoate metabolism Bladder cancer 0 -0.816205534 -0.586100386 kegg kegg NA NA no no no no no no Prostate cancer Bladder cancer 0 0.663043478 0 kegg kegg NA NA no no no no no no Proteasome Bladder cancer 0 -0.749011858 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Bladder cancer 0 0.584980237 0.401801802 yes kegg kegg NA NA no up up no no no Protein export Bladder cancer -0.485217391 -0.830039526 -0.485199485 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Bladder cancer -0.739130435 -0.826086957 -0.571171171 kegg kegg NA NA no no no no no no Proteoglycans in cancer Bladder cancer 0 -0.774703557 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Bladder cancer -0.432173913 -0.773715415 -0.417245817 kegg kegg NA NA no no no no no no Purine metabolism Bladder cancer -0.50173913 -0.449604743 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Bladder cancer 0 -0.650197628 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Bladder cancer 0 -0.896245059 -0.593822394 kegg kegg NA NA no no no no no no Ras signaling pathway Bladder cancer 0 -0.68972332 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Bladder cancer 0 -0.497035573 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Bladder cancer 0 0.658102767 0 kegg kegg NA NA no no no no no no Renin secretion Bladder cancer -0.607826087 -0.707509881 -0.438095238 kegg kegg NA NA no no no no no no Renin-angiotensin system Bladder cancer 0.633913043 0.640316206 0.529214929 kegg kegg NA NA no no no no no no Retinol metabolism Bladder cancer 0 -0.515810277 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Bladder cancer 0 -0.714426877 0 kegg kegg NA NA no no up no no no Ribosome Bladder cancer -0.528695652 -0.752964427 -0.416988417 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Bladder cancer -0.477391304 -0.697628458 -0.531016731 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Bladder cancer 0.579130435 0.852766798 0.427541828 kegg kegg NA NA no no no no no no RNA degradation Bladder cancer 0 -0.807312253 -0.475160875 kegg kegg NA NA no no no no no no RNA polymerase Bladder cancer -0.462608696 -0.813241107 -0.539253539 kegg kegg NA NA no no no no no no RNA transport Bladder cancer 0 -0.711462451 -0.503989704 kegg kegg NA NA no no no no no no Salmonella infection Bladder cancer 0.562608696 0 0 kegg kegg NA NA no no no no no no Shigellosis Bladder cancer 0 -0.440711462 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Bladder cancer 0 0.556324111 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Bladder cancer 0.517391304 0 0.402059202 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Bladder cancer 0.439130435 0.458498024 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Bladder cancer 0 -0.587944664 0 kegg kegg NA NA no no no no no no Spliceosome Bladder cancer 0 0 -0.47979408 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Bladder cancer 0.454782609 0.442687747 0.510939511 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Bladder cancer 0.58173913 0.77173913 0.576833977 kegg kegg NA NA no no no no no no Steroid biosynthesis Bladder cancer -0.527826087 -0.615612648 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Bladder cancer 0 -0.517786561 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Bladder cancer 0.608695652 0.60770751 0.654568855 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Bladder cancer 0 -0.700592885 0 kegg kegg NA NA no no no no no no Taste transduction Bladder cancer 0 -0.630434783 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Bladder cancer 0 0.447628458 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Bladder cancer 0 -0.441699605 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Bladder cancer 0 -0.773715415 0 kegg kegg NA NA no no no no no no Thermogenesis Bladder cancer 0 -0.805335968 -0.527927928 kegg kegg NA NA no no no no no no Thiamine metabolism Bladder cancer 0 -0.699604743 0 kegg kegg NA NA no no no no no no Thyroid cancer Bladder cancer 0 0 -0.465637066 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Bladder cancer 0 -0.491106719 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Bladder cancer -0.78173913 0 0 kegg kegg NA NA no no no no no no Tight junction Bladder cancer 0 -0.46541502 0 kegg kegg NA NA no no no no no no TNF signaling pathway Bladder cancer 0 0.776679842 0.435778636 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Bladder cancer 0.659130435 0.895256917 0.625482625 yes kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Bladder cancer 0.469565217 0.805335968 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Bladder cancer 0 -0.598814229 0 kegg kegg NA NA no up no no no no Tuberculosis Bladder cancer 0.619130435 0.563241107 0.58970399 kegg kegg NA NA no no dn no no no Type II diabetes mellitus Bladder cancer 0.41826087 0.679841897 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Bladder cancer 0 -0.726284585 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Bladder cancer 0 -0.625494071 -0.516602317 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Bladder cancer -0.628695652 -0.587944664 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Bladder cancer 0 -0.752964427 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Bladder cancer 0 -0.719367589 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Bladder cancer -0.466956522 -0.596837945 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Bladder cancer -0.580869565 -0.505928854 -0.417503218 kegg kegg NA NA no no no no no no VEGF signaling pathway Bladder cancer 0 0.626482213 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Bladder cancer 0 -0.435770751 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Bladder cancer 0 0.598814229 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Bladder cancer 0 -0.82312253 0 kegg kegg NA NA no no no no no no Yersinia infection Bladder cancer 0.594782609 0.529644269 0 kegg kegg NA NA no no no no no no Bacteroides Blautia 0.662820707 0 0 LPS-producing acetate-producing Genus Genus 0.000267 1.36E-05 dn dn up up dn dn 14:0+blood BMI+clinic 0 0 -0.414615385 yes yes serum_fattyacid clinic 0.00572 0.00527 up no dn no up no 16:1+blood BMI+clinic 0 -0.821428571 0 yes yes serum_fattyacid clinic 0.0186 0.00527 no no dn no up no 18:0/18:0-PS+blood BMI+clinic 0 -0.582142857 0 yes serum_phospholipids clinic 0.00617 0.00527 no up no no up no 18:0/20:3-PI+blood BMI+clinic 0 0 -0.41 yes serum_phospholipids clinic 0.377 0.00527 no no no no up no 18:0/22:6-PE+blood BMI+clinic 0 -0.55 0 yes serum_phospholipids clinic 0.00022 0.00527 up up no no up no 18:2-LPE+blood BMI+clinic 0 0 0.504615385 yes serum_phospholipids clinic 0.112 0.00527 no no no no up no 18:3n6+blood BMI+clinic 0 -0.603571429 0 yes serum_fattyacid clinic 0.0463 0.00527 up no dn no up no 20:4-LPA+blood BMI+clinic 0 0.653571429 0 yes serum_phospholipids clinic 0.398 0.00527 no no no no up no 20:4/18:0-PE+blood BMI+clinic 0 -0.514285714 0 yes serum_phospholipids clinic 0.000755 0.00527 up up no no up no 22:6n3+blood BMI+clinic 0 0 -0.436923077 yes serum_fattyacid clinic 0.792 0.00527 no no no no up no Adipocytokine signaling pathway BMI+clinic -0.471485037 0 0 yes kegg clinic NA 0.00527 no no no no up no Adrenergic signaling in cardiomyocytes BMI+clinic -0.446640316 0 0.449859944 yes kegg clinic NA 0.00527 no no up no up no Akkermansia BMI+clinic 0 0 -0.460717645 acetate-producing yes Genus clinic 0.23 0.00527 no no no no up no Aldosterone synthesis and secretion BMI+clinic -0.465838509 0 0 yes kegg clinic NA 0.00527 no up up no up no Alzheimer disease BMI+clinic -0.434217956 0 0 yes kegg clinic NA 0.00527 no no no no up no Amyotrophic lateral sclerosis BMI+clinic -0.485036702 0 0 yes kegg clinic NA 0.00527 no no no no up no C-peptide BMI+clinic -0.458498024 0 0 yes DM-assocaited hormones clinic 0.228 0.00527 no no no no up no Calcium signaling pathway BMI+clinic -0.465838509 0 0 yes kegg clinic NA 0.00527 no up up no up no cAMP signaling pathway BMI+clinic -0.477131564 0 0 yes yes kegg clinic NA 0.00527 no up up no up no Carbon metabolism BMI+clinic 0 0 -0.421848739 yes kegg clinic NA 0.00527 no no no no up no Cardiac muscle contraction BMI+clinic -0.470355731 0 0 yes kegg clinic NA 0.00527 no no up no up no Choline+blood BMI+clinic -0.486068111 0 0 yes serum_choline clinic 0.0395 0.00527 no up no no up no Cholinergic synapse BMI+clinic 0 0 0.43557423 yes kegg clinic NA 0.00527 no no no no up no Circadian entrainment BMI+clinic 0 -0.520779221 0 yes kegg clinic NA 0.00527 no up up no up no Cushing syndrome BMI+clinic -0.445511011 0 0 yes kegg clinic NA 0.00527 no no up no up no d18:1-18:0-SM+blood BMI+clinic 0 0 0.439230769 yes serum_phospholipids clinic 0.97 0.00527 no no no no up no d18:1-20:1-SM+blood BMI+clinic 0 0 0.416923077 yes serum_phospholipids clinic 0.0992 0.00527 no no no no up no d18:1-24:1-SM+blood BMI+clinic 0.558307534 0 0 yes serum_phospholipids clinic 0.0123 0.00527 no dn dn no up no Diabetic cardiomyopathy BMI+clinic -0.46809712 0 0 yes kegg clinic NA 0.00527 no no no no up no Eotaxin BMI+clinic 0 0.507017544 0 yes serum_cytokines clinic 0.393 0.00527 no no no no up no Faecalibacterium BMI+clinic 0 -0.4432524 0 butyrate-producing yes Genus clinic 0.0039 0.00527 no dn dn no up no Glycolysis / Gluconeogenesis BMI+clinic 0 0 -0.437535014 yes kegg clinic NA 0.00527 no no no no up no GnRH signaling pathway BMI+clinic -0.447769622 0 0 yes kegg clinic NA 0.00527 no no no no up no GPC+blood BMI+clinic 0 0.514285714 0 yes serum_choline clinic 0.00427 0.00527 no up up no up no Hepatitis C BMI+clinic 0 0.458441558 0 yes kegg clinic NA 0.00527 no no no no up no Huntington disease BMI+clinic -0.422924901 0 0 yes kegg clinic NA 0.00527 no no no no up no Inflammatory mediator regulation of TRP channels BMI+clinic 0 -0.498701299 0 yes kegg clinic NA 0.00527 no no no no up no IP-10 BMI+clinic 0.648351648 0 0 yes serum_cytokines clinic 0.394 0.00527 no no no no up no Kaposi sarcoma-associated herpesvirus infection BMI+clinic -0.571993224 0 0 yes kegg clinic NA 0.00527 no no dn no up no L-Glutamine+blood BMI+clinic 0 0.528571429 0 yes serum_aminoacids clinic 0.639 0.00527 no no no no up no L-Isoleucine+blood BMI+clinic 0 0 -0.413846154 yes yes serum_aminoacids clinic 5.47E-06 0.00527 up up no no up no L-Phenylalanine+stool BMI+clinic 0 0.718181818 -0.436476567 yes stool_cometabolism clinic 0.398 0.00527 no no no no up no L-Proline+blood BMI+clinic 0 0 0.41 yes yes serum_aminoacids clinic 0.00265 0.00527 up up no no up no L-Tryptophan+stool BMI+clinic 0 0 -0.464709204 yes stool_cometabolism clinic 0.557 0.00527 no no no no up no Long-term depression BMI+clinic -0.513269339 0 0 yes kegg clinic NA 0.00527 no no no no up no Long-term potentiation BMI+clinic 0 0 0.546218487 yes kegg clinic NA 0.00527 no no up no up no Longevity regulating pathway - multiple species BMI+clinic 0.429700734 0 0 yes kegg clinic NA 0.00527 no no no no up no Measles BMI+clinic 0 0.683116883 0 yes kegg clinic NA 0.00527 no no no no up no Methanobrevibacter BMI+clinic 0 0.446959858 0 yes Genus clinic 0.629 0.00527 no no no no up no Mineral absorption BMI+clinic -0.427442123 0 0 yes kegg clinic NA 0.00527 no no no no up no MIP-1b BMI+clinic 0 0 0.442364532 yes serum_cytokines clinic 0.632 0.00527 no no no no up no Mitophagy - animal BMI+clinic -0.472614342 0 0 yes kegg clinic NA 0.00527 no no no no up no Morphine addiction BMI+clinic -0.447769622 -0.466233766 0 yes kegg clinic NA 0.00527 no up up no up no Non-alcoholic fatty liver disease BMI+clinic -0.472614342 0 0 yes kegg clinic NA 0.00527 no no no no up no Odoribacter BMI+clinic 0.42542348 0 0 butyrate-producing yes Genus clinic 0.798 0.00527 no no no no up no Oocyte meiosis BMI+clinic 0 0 0.427170868 yes kegg clinic NA 0.00527 no no no no up no Oscillospira BMI+clinic 0 0.488424619 0 LPS-producing yes Genus clinic 0.62 0.00527 no no no no up no Oxidative phosphorylation BMI+clinic -0.438735178 0 0 yes kegg clinic NA 0.00527 no no no no up no Pancreatic secretion BMI+clinic -0.548277809 0 0 yes kegg clinic NA 0.00527 no no no no up no Parabacteroides BMI+clinic 0 0.451157538 0 yes Genus clinic 4.19E-05 0.00527 no up up no up no Paraprevotella BMI+clinic 0 -0.526103361 0 yes Genus clinic 0.118 0.00527 no no no no up no "Parathyroid hormone synthesis, secretion and action" BMI+clinic -0.494071146 0 0 yes kegg clinic NA 0.00527 no no no no up no Parkinson disease BMI+clinic -0.520045172 0 0 yes kegg clinic NA 0.00527 no no no no up no Pathways of neurodegeneration - multiple diseases BMI+clinic -0.532467532 0 0 yes kegg clinic NA 0.00527 no no no no up no Peroxisome BMI+clinic 0.431959345 0 0 yes kegg clinic NA 0.00527 no no no no up no Phenylacetic acid+stool BMI+clinic 0 0 -0.476002259 yes stool_cometabolism clinic 0.785 0.00527 no no no no up no Primary immunodeficiency BMI+clinic 0.602484472 0 0 yes kegg clinic NA 0.00527 no no no no up no PUFA+blood BMI+clinic 0 0 -0.516153846 yes serum_fattyacid clinic 0.212 0.00527 no no no no up no RANTES BMI+clinic 0.659340659 0 0 yes yes serum_cytokines clinic 0.0757 0.00527 no no up no up no Relaxin signaling pathway BMI+clinic -0.447769622 0 0 yes kegg clinic NA 0.00527 no no no no up no Renin secretion BMI+clinic 0 -0.450649351 0 yes kegg clinic NA 0.00527 no no no no up no Roseburia BMI+clinic 0 -0.44224797 0 butyrate-producing yes Genus clinic 0.495 0.00527 no no no no up no Salivary secretion BMI+clinic 0 -0.487012987 0 yes kegg clinic NA 0.00527 no no no no up no Salmonella infection BMI+clinic 0 0.433766234 0 yes kegg clinic NA 0.00527 no no no no up no T cell receptor signaling pathway BMI+clinic 0 0.44025974 0 yes kegg clinic NA 0.00527 no no no no up no Taurine+blood BMI+clinic 0 0.575 0 yes serum_aminoacids clinic 0.857 0.00527 no no no no up no Th1 and Th2 cell differentiation BMI+clinic 0 0.449350649 0 yes kegg clinic NA 0.00527 no no no no up no Th17 cell differentiation BMI+clinic 0 0.541558442 0 yes kegg clinic NA 0.00527 no no no no up no Thermogenesis BMI+clinic -0.427442123 0 0 yes kegg clinic NA 0.00527 no no no no up no ToFA+blood BMI+clinic 0 0 -0.403846154 yes serum_fattyacid clinic 0.0307 0.00527 up no dn no up no Toxoplasmosis BMI+clinic 0.436476567 0.487012987 0 yes kegg clinic NA 0.00527 no no no no up no Ubiquitin mediated proteolysis BMI+clinic -0.456804065 0 0 yes kegg clinic NA 0.00527 no no no no up no UFA+blood BMI+clinic 0 0 -0.403076923 yes serum_fattyacid clinic 0.0444 0.00527 up no dn no up no Visfatin BMI+clinic 0.499011858 0 0 yes DM-assocaited hormones clinic 0.0229 0.00527 dn no up no up no 2-Oxocarboxylic acid metabolism Breast cancer -0.586956522 -0.451581028 0 kegg kegg NA NA no no no no no no ABC transporters Breast cancer 0 0.621541502 0 kegg kegg NA NA no up up no no no Acute myeloid leukemia Breast cancer 0.640869565 0.65513834 0.611840412 kegg kegg NA NA no no no no no no Adherens junction Breast cancer -0.417391304 -0.733201581 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Breast cancer 0 0.541501976 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Breast cancer 0 -0.460474308 0 kegg kegg NA NA no no up no no no African trypanosomiasis Breast cancer 0.524347826 0.444664032 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Breast cancer 0.509565217 0.706521739 0.609266409 kegg kegg NA NA no no no no no no Akkermansia Breast cancer 0 -0.533553267 0 acetate-producing Genus kegg 0.23 NA no no no no no no "Alanine, aspartate and glutamate metabolism" Breast cancer 0 0.632411067 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Breast cancer 0.756521739 0.491106719 0.675675676 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Breast cancer -0.414782609 0.471343874 0 kegg kegg NA NA no no no no no no Alzheimer disease Breast cancer 0 -0.656126482 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Breast cancer -0.520869565 0 0 kegg kegg NA NA no no no no no no Amoebiasis Breast cancer 0 0.489130435 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Breast cancer 0 -0.650197628 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Breast cancer 0 -0.46541502 -0.492664093 kegg kegg NA NA no no no no no no Apelin signaling pathway Breast cancer 0 -0.695652174 0 kegg kegg NA NA no no no no no no Apoptosis Breast cancer 0 0.514822134 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Breast cancer 0 0.593873518 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Breast cancer -0.662608696 0 -0.521750322 kegg kegg NA NA no no no no no no Arginine and proline metabolism Breast cancer 0 0.558300395 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Breast cancer 0 0.545454545 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Breast cancer -0.429565217 -0.45256917 0 kegg kegg NA NA no no no no no no Autophagy - animal Breast cancer 0.696521739 0.855731225 0.671299871 kegg kegg NA NA no no no no no no Autophagy - other Breast cancer 0.52 0.570158103 0.638095238 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Breast cancer 0.509565217 0.634387352 0.411325611 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Breast cancer -0.433043478 -0.709486166 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Breast cancer 0.426086957 0 0.628056628 kegg kegg NA NA no no no no no no beta-Alanine metabolism Breast cancer -0.668695652 -0.508893281 0 kegg kegg NA NA no no no no no no Bifidobacterium Breast cancer 0 -0.491829146 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Biosynthesis of amino acids Breast cancer -0.457391304 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Breast cancer -0.529565217 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Breast cancer -0.543478261 -0.41798419 0 kegg kegg NA NA no no no no no no Bladder cancer Breast cancer 0 0.683794466 0 kegg kegg NA NA no no no no no no Butanoate metabolism Breast cancer -0.605217391 -0.600790514 -0.415444015 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Breast cancer 0.720869565 0.657114625 0.535135135 kegg kegg NA NA no no no no no no cAMP signaling pathway Breast cancer 0.57826087 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Breast cancer 0.820869565 0.774703557 0.788159588 kegg kegg NA NA no no no no no no Carbon metabolism Breast cancer -0.64 -0.416007905 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Breast cancer 0 -0.617588933 0 kegg kegg NA NA no no up no no no cGMP-PKG signaling pathway Breast cancer 0.506086957 0 0 kegg kegg NA NA no no no no no no Chagas disease Breast cancer 0.619130435 0.665019763 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Breast cancer -0.510434783 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Breast cancer 0.485217391 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Breast cancer 0.759130435 0 0.688803089 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Breast cancer 0.670434783 0.636363636 0.587387387 kegg kegg NA NA no no no no no no Circadian entrainment Breast cancer 0 -0.554347826 -0.46048906 kegg kegg NA NA no up up no no no Circadian rhythm Breast cancer 0.586956522 0 0.544916345 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Breast cancer -0.577391304 -0.684782609 0 kegg kegg NA NA no no no no no no Clostridium Breast cancer 0 -0.544042123 0 Genus kegg 0.925 NA no no no no no no Collecting duct acid secretion Breast cancer 0 0 -0.423166023 kegg kegg NA NA no no no no no no Collinsella Breast cancer 0 0 -0.512585492 Genus kegg 0.128 NA no no no no no no Colorectal cancer Breast cancer 0.75826087 0.494071146 0.866151866 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Breast cancer 0 -0.664031621 -0.418018018 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Breast cancer 0 -0.662055336 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Breast cancer 0 0 -0.483397683 kegg kegg NA NA no no no no no no DNA replication Breast cancer 0 -0.52173913 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Breast cancer 0 -0.508893281 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Breast cancer -0.645217391 -0.739130435 -0.404118404 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Breast cancer -0.740869565 -0.769762846 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Breast cancer 0 -0.537549407 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Breast cancer 0 -0.480237154 0 kegg kegg NA NA no no no no no no Endocrine resistance Breast cancer 0.409565217 0 0 kegg kegg NA NA no no no no no no Endometrial cancer Breast cancer 0.809565217 0.801383399 0.891891892 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Breast cancer 0 0.424901186 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Breast cancer 0.825217391 0.81027668 0.902187902 kegg kegg NA NA no no no no no no Estrogen signaling pathway Breast cancer 0 -0.449604743 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Breast cancer 0 0.658102767 0 kegg kegg NA NA no no no no no no Fatty acid degradation Breast cancer 0 0.529644269 0 kegg kegg NA NA no no no no no no Fatty acid elongation Breast cancer -0.677391304 -0.552371542 -0.49034749 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Breast cancer 0.684347826 0.675889328 0.4998713 kegg kegg NA NA no no no no no no Ferroptosis Breast cancer 0 0 -0.46048906 kegg kegg NA NA no no no no no no Focal adhesion Breast cancer -0.406956522 -0.778656126 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Breast cancer 0.493043478 0.809288538 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Breast cancer -0.406956522 0.654150198 0 kegg kegg NA NA no no no no no no GABAergic synapse Breast cancer 0 0.442687747 0 kegg kegg NA NA no up up no no no Galactose metabolism Breast cancer 0 0.576086957 0 kegg kegg NA NA no no no no no no Gastric acid secretion Breast cancer -0.411304348 -0.752964427 0 kegg kegg NA NA no no no no no no Glioma Breast cancer 0.602608696 0 0.603346203 kegg kegg NA NA no no no no no no Glucagon signaling pathway Breast cancer 0 -0.431818182 0 kegg kegg NA NA no no no no no no Glutathione metabolism Breast cancer -0.566086957 -0.540513834 -0.562162162 kegg kegg NA NA no no no no no no Glycerolipid metabolism Breast cancer 0 0.718379447 0.545688546 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Breast cancer 0.451304348 0.617588933 0.506563707 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Breast cancer -0.429565217 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Breast cancer -0.666086957 -0.745059289 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Breast cancer 0 0.889328063 0.514285714 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Breast cancer -0.529565217 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Breast cancer -0.426086957 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Breast cancer 0.482608696 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Breast cancer 0 0.531620553 0 kegg kegg NA NA no no no no no no GnRH secretion Breast cancer 0.850434783 0.807312253 0.818275418 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Breast cancer 0.749565217 0.701581028 0.428571429 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Breast cancer 0.502608696 0 0.642728443 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Breast cancer 0 -0.463438735 0 kegg kegg NA NA no no no no no no Hepatitis B Breast cancer 0.74173913 0.836956522 0.747747748 kegg kegg NA NA no no no no no no Hepatitis C Breast cancer 0.533043478 0 0.584813385 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Breast cancer 0 0 -0.403603604 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Breast cancer 0 -0.627470356 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Breast cancer -0.455652174 -0.711462451 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Breast cancer 0 0.523715415 0.458944659 kegg kegg NA NA no no no no no no Huntington disease Breast cancer 0 -0.647233202 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Breast cancer 0 -0.503952569 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Breast cancer 0 0.686758893 0.517631918 kegg kegg NA NA no no no no no no Insulin resistance Breast cancer 0.777391304 0.807312253 0.658944659 kegg kegg NA NA no no no no no no Insulin signaling pathway Breast cancer 0 -0.643280632 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Breast cancer 0.44 0.85770751 0 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Breast cancer 0 0 -0.413127413 kegg kegg NA NA no no dn no no no Lachnospira Breast cancer 0 -0.432913282 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Leishmaniasis Breast cancer -0.431304348 -0.432806324 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Breast cancer 0 -0.503952569 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Breast cancer -0.590434783 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Breast cancer 0 -0.54743083 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Breast cancer 0.43826087 0.46541502 0 kegg kegg NA NA no no no no no no Lysine degradation Breast cancer 0 0 0.57039897 kegg kegg NA NA no no no no no no Malaria Breast cancer 0 0 -0.478764479 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Breast cancer 0.48 0 0.516344916 kegg kegg NA NA no no no no no no MAPK signaling pathway Breast cancer 0.42 0.551383399 0.772972973 kegg kegg NA NA no no no no no no Measles Breast cancer 0.453043478 0 0 kegg kegg NA NA no no no no no no Melanogenesis Breast cancer 0 -0.548418972 0 kegg kegg NA NA no no no no no no Melanoma Breast cancer 0.85826087 0.786561265 0.856628057 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Breast cancer -0.709565217 -0.768774704 -0.454054054 kegg kegg NA NA no no no no no no MicroRNAs in cancer Breast cancer 0.503478261 0.792490119 0.866924067 kegg kegg NA NA no no no no no no Mineral absorption Breast cancer 0 0 -0.518404118 kegg kegg NA NA no no no no no no Mismatch repair Breast cancer -0.440869565 -0.530632411 0 kegg kegg NA NA no no no no no no Mitophagy - animal Breast cancer 0 -0.443675889 -0.422908623 kegg kegg NA NA no no no no no no mRNA surveillance pathway Breast cancer 0.486956522 0 0.473101673 kegg kegg NA NA no no no no no no mTOR signaling pathway Breast cancer 0 -0.52173913 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Breast cancer 0 -0.490118577 0 kegg kegg NA NA no no no no no no Necroptosis Breast cancer 0 0 -0.487001287 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Breast cancer 0.606086957 0.5256917 0.534362934 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Breast cancer 0.511304348 0.792490119 0.544401544 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Breast cancer 0 0.612648221 0 kegg kegg NA NA no no no no no no Nicotine addiction Breast cancer 0 0.441699605 0 kegg kegg NA NA no up up no no no Nitrogen metabolism Breast cancer 0 0.504940711 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Breast cancer 0 0.648221344 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Breast cancer 0 -0.541501976 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Breast cancer -0.591304348 -0.575098814 -0.413899614 kegg kegg NA NA no no no no no no Non-small cell lung cancer Breast cancer 0.850434783 0.793478261 0.813127413 kegg kegg NA NA no no no no no no Notch signaling pathway Breast cancer 0.6 0.70256917 0.587387387 kegg kegg NA NA no no no no no no Nucleotide excision repair Breast cancer 0 -0.433794466 0 kegg kegg NA NA no no no no no no Oocyte meiosis Breast cancer 0 -0.716403162 0 kegg kegg NA NA no no no no no no Oscillospira Breast cancer 0 0.41798419 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Breast cancer 0 0.564229249 0 kegg kegg NA NA no no no no no no Other glycan degradation Breast cancer 0 0.541501976 0.464092664 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Breast cancer 0 0 0.523552124 kegg kegg NA NA no no no no no no Oxidative phosphorylation Breast cancer 0 -0.662055336 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Breast cancer 0 -0.531620553 -0.438095238 kegg kegg NA NA no no no no no no p53 signaling pathway Breast cancer 0.517391304 0.557312253 0 kegg kegg NA NA no no no no no no Pancreatic cancer Breast cancer 0.502608696 0 0.425740026 kegg kegg NA NA no no no no no no Pancreatic secretion Breast cancer 0 -0.510869565 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Breast cancer 0 0.479249012 0 kegg kegg NA NA no no dn no no no Paraprevotella Breast cancer -0.461170482 0 0 Genus kegg 0.118 NA no no no no no no Parkinson disease Breast cancer 0 -0.638339921 -0.521235521 kegg kegg NA NA no no no no no no Pathways in cancer Breast cancer 0.665217391 0.725296443 0.443758044 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Breast cancer 0 -0.617588933 -0.506048906 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Breast cancer -0.713913043 -0.621541502 0 kegg kegg NA NA no no no no no no Peroxisome Breast cancer 0 0.444664032 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Breast cancer -0.664347826 -0.62944664 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Breast cancer 0.505217391 0 0.580952381 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Breast cancer 0.432173913 0.713438735 0 kegg kegg NA NA no up up no no no Phototransduction Breast cancer 0 -0.851778656 0 kegg kegg NA NA no no no no no no Platelet activation Breast cancer -0.416521739 -0.679841897 0 kegg kegg NA NA no no no no no no Platinum drug resistance Breast cancer 0 0.548418972 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Breast cancer 0 0.527667984 0 kegg kegg NA NA no no no no no no Prevotella Breast cancer 0 0.550154956 0 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Breast cancer -0.539130435 -0.590909091 0 kegg kegg NA NA no no no no no no Prion disease Breast cancer 0 -0.73715415 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Breast cancer 0.524347826 0.48715415 0.599227799 kegg kegg NA NA no no no no no no Prolactin signaling pathway Breast cancer 0.815652174 0.789525692 0.675675676 kegg kegg NA NA no no no no no no Propanoate metabolism Breast cancer 0 -0.652173913 0 kegg kegg NA NA no no no no no no Prostate cancer Breast cancer 0.737391304 0.653162055 0.574002574 kegg kegg NA NA no no no no no no Proteasome Breast cancer 0 -0.750988142 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Breast cancer 0 0.593873518 0.46975547 yes kegg kegg NA NA no up up no no no Protein export Breast cancer 0 -0.72826087 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Breast cancer 0 -0.471343874 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Breast cancer 0 -0.64229249 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Breast cancer 0 -0.656126482 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Breast cancer -0.493043478 -0.435770751 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Breast cancer -0.407826087 -0.657114625 -0.48030888 kegg kegg NA NA no no no no no no Rap1 signaling pathway Breast cancer 0 -0.492094862 0 kegg kegg NA NA no no no no no no Ras signaling pathway Breast cancer 0 -0.549407115 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Breast cancer -0.648695652 -0.763833992 -0.552123552 kegg kegg NA NA no no no no no no Relaxin signaling pathway Breast cancer 0.583478261 0.528656126 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Breast cancer 0.436521739 0 0 kegg kegg NA NA no no no no no no Renin secretion Breast cancer 0 -0.67687747 -0.403861004 kegg kegg NA NA no no no no no no Retinol metabolism Breast cancer -0.52173913 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Breast cancer 0 -0.751976285 0 kegg kegg NA NA no no up no no no Ribosome Breast cancer 0 -0.662055336 -0.417245817 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Breast cancer 0.589565217 0.739130435 0.466666667 kegg kegg NA NA no no no no no no RNA degradation Breast cancer 0.440869565 -0.425889328 0.43011583 kegg kegg NA NA no no no no no no RNA transport Breast cancer 0 -0.481225296 0 kegg kegg NA NA no no no no no no Ruminococcus Breast cancer 0 -0.429421822 0 Genus kegg 0.0679 NA no no dn no no no Shigellosis Breast cancer 0 -0.535573123 -0.552123552 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Breast cancer 0.753913043 0.592885375 0.774259974 kegg kegg NA NA no no no no no no Small cell lung cancer Breast cancer 0.600869565 0.743083004 0.47979408 kegg kegg NA NA no no up no no no SNARE interactions in vesicular transport Breast cancer 0 0.618577075 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Breast cancer 0.636521739 0 0.522779923 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Breast cancer 0.587826087 0 0 kegg kegg NA NA no no no no no no Spliceosome Breast cancer 0 0.415019763 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Breast cancer -0.42 0 0 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Breast cancer 0 0.587944664 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Breast cancer 0 -0.494071146 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Breast cancer -0.692173913 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Breast cancer -0.597391304 -0.429841897 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Breast cancer 0.447826087 0.564229249 0.438095238 kegg kegg NA NA no no no no no no Taste transduction Breast cancer 0 0 0.486229086 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Breast cancer 0.506086957 0.755928854 0.529214929 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Breast cancer 0 -0.682806324 0 kegg kegg NA NA no no no no no no Thermogenesis Breast cancer 0 -0.686758893 0 kegg kegg NA NA no no no no no no Thiamine metabolism Breast cancer 0 -0.537549407 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Breast cancer 0 -0.527667984 0 kegg kegg NA NA no no no no no no Tight junction Breast cancer -0.519130435 -0.815217391 -0.618790219 kegg kegg NA NA no no no no no no TNF signaling pathway Breast cancer 0.729565217 0.746047431 0.460746461 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Breast cancer 0.627826087 0.626482213 0 yes kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Breast cancer 0.539130435 0.821146245 0.545945946 kegg kegg NA NA no no no no no no Tryptophan metabolism Breast cancer -0.613043478 -0.588932806 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Breast cancer 0.857391304 0.868577075 0.71042471 kegg kegg NA NA no no no no no no Tyrosine metabolism Breast cancer -0.664347826 -0.557312253 -0.498841699 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Breast cancer -0.537391304 -0.446640316 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Breast cancer 0 -0.479249012 -0.452252252 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Breast cancer -0.537391304 -0.5256917 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Breast cancer 0 -0.754940711 -0.43989704 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Breast cancer 0 -0.526679842 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Breast cancer 0.78 0.59486166 0.694723295 kegg kegg NA NA no no no no no no Vibrio cholerae infection Breast cancer 0 -0.678853755 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Breast cancer 0 0 -0.625225225 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Breast cancer 0.533913043 0 0.43963964 kegg kegg NA NA no no no no no no Wnt signaling pathway Breast cancer 0 0 0.513513514 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Butanoate metabolism 0 -0.668972332 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Butanoate metabolism 0.629565217 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Butanoate metabolism 0.651304348 0 0.425225225 kegg kegg NA NA no no no no no no Arginine and proline metabolism Butanoate metabolism 0 -0.631422925 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Butanoate metabolism 0 -0.674901186 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Butanoate metabolism 0.42 0.504940711 0.507078507 kegg kegg NA NA no no no no no no beta-Alanine metabolism Butanoate metabolism 0.86 0.717391304 0.773230373 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Butanoate metabolism 0.826086957 0.949604743 0.702702703 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Butanoate metabolism 0.535652174 0.902173913 0.6996139 kegg kegg NA NA no no no no no no Ether lipid metabolism Butanoate metabolism 0 0.416007905 0.427541828 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Butanoate metabolism 0 -0.618577075 0 kegg kegg NA NA no no no no no no Fatty acid degradation Butanoate metabolism 0.434782609 0 0.480566281 kegg kegg NA NA no no no no no no Fatty acid elongation Butanoate metabolism 0.696521739 0.699604743 0.80978121 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Butanoate metabolism 0.7 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Butanoate metabolism 0.645217391 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Butanoate metabolism 0 0.416996047 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Butanoate metabolism 0.446956522 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Butanoate metabolism 0.813913043 0.759881423 0.646332046 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Butanoate metabolism 0 -0.733201581 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Butanoate metabolism 0.685217391 0.577075099 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Butanoate metabolism 0 0.601778656 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Butanoate metabolism -0.454782609 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Butanoate metabolism 0 -0.673913043 0 kegg kegg NA NA no no no no no no Histidine metabolism Butanoate metabolism 0.527826087 0 0.409009009 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Butanoate metabolism 0 0.768774704 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Butanoate metabolism -0.556521739 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Butanoate metabolism 0.599130435 0.914031621 0.56988417 kegg kegg NA NA no no no no no no Pentose phosphate pathway Butanoate metabolism 0 -0.432806324 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Butanoate metabolism 0.740869565 0.861660079 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Butanoate metabolism 0.736521739 0.693675889 0.522007722 kegg kegg NA NA no no no no no no Propanoate metabolism Butanoate metabolism 0.639130435 0.861660079 0.754440154 kegg kegg NA NA no no no no no no Pyrimidine metabolism Butanoate metabolism 0.71826087 0.68972332 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Butanoate metabolism 0.705217391 0.873517787 0.783011583 kegg kegg NA NA no no no no no no Selenocompound metabolism Butanoate metabolism 0 0 0.406435006 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Butanoate metabolism 0 -0.494071146 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Butanoate metabolism 0 0.696640316 0.596396396 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Butanoate metabolism 0.499130435 0.761857708 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Butanoate metabolism 0.651304348 0.770750988 0.715830116 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Butanoate metabolism 0 -0.445652174 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Butanoate metabolism 0.915652174 0.851778656 0.814157014 kegg kegg NA NA no up no no no no Tyrosine metabolism Butanoate metabolism 0.707826087 0.866600791 0.713770914 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Butanoate metabolism 0.780869565 0.851778656 0.60952381 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Butanoate metabolism 0.895652174 0.941699605 0.906048906 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Butanoate metabolism 0 0.698616601 0 kegg kegg NA NA no no no no no no 15-HETE+blood butyric acid C4+blood 0.456073694 0 0 serum_ARA serum_scfa 0.819 0.407 no no no no no no 16:0/14:0-PC+blood butyric acid C4+blood 0 -0.517156863 0 serum_phospholipids serum_scfa 0.0206 0.407 no up up no no no 16:0/18:0-PC+blood butyric acid C4+blood 0 -0.495098039 0 serum_phospholipids serum_scfa 0.521 0.407 no no no no no no 16:0/20:3-PC+blood butyric acid C4+blood 0 -0.558823529 0 serum_phospholipids serum_scfa 5.43E-06 0.407 no up up no no no 16:1/16:1-PC+blood butyric acid C4+blood 0 -0.573529412 0 serum_phospholipids serum_scfa 0.0177 0.407 no no up no no no 18:0/18:0-PC+blood butyric acid C4+blood 0 -0.571078431 0 serum_phospholipids serum_scfa 0.426 0.407 no no no no no no 18:0/18:1-PC+blood butyric acid C4+blood 0 -0.526960784 0 serum_phospholipids serum_scfa 0.393 0.407 no no no no no no 18:0/18:1-PI+blood butyric acid C4+blood -0.572932331 0 0 serum_phospholipids serum_scfa 0.599 0.407 no no no no no no 18:0/20:3-PC+blood butyric acid C4+blood 0 -0.49754902 0 serum_phospholipids serum_scfa 0.0682 0.407 no up no no no no 18:0/20:5-PC+blood butyric acid C4+blood 0.584962406 0 0 serum_phospholipids serum_scfa 0.17 0.407 no no no no no no 18:0/22:6-PA+blood butyric acid C4+blood 0 -0.617647059 0 serum_phospholipids serum_scfa 0.22 0.407 no no no no no no 18:1/16:0-PI+blood butyric acid C4+blood -0.542857143 0 0 serum_phospholipids serum_scfa 0.793 0.407 no no no no no no 18:1/18:2-PI+blood butyric acid C4+blood -0.493233083 0 0 serum_phospholipids serum_scfa 0.0164 0.407 dn no up no no no 18:2-LPC+blood butyric acid C4+blood 0 0.541666667 0 serum_phospholipids serum_scfa 0.00743 0.407 dn no up no no no 18:3-LPC+blood butyric acid C4+blood 0 0.492647059 0 serum_phospholipids serum_scfa 0.147 0.407 no no no no no no 18:3n3+blood butyric acid C4+blood 0.44962406 0 0 serum_fattyacid serum_scfa 0.291 0.407 no no no no no no 2-methyl-butyric acid m-C4+blood butyric acid C4+blood 0.490225564 0 0.573333333 serum_scfa serum_scfa 0.262 0.407 no no no no no no 20:2/18:0-PC+blood butyric acid C4+blood 0 -0.487745098 0 serum_phospholipids serum_scfa 0.0427 0.407 no up no no no no 20:3/18:0-PC+blood butyric acid C4+blood 0 -0.514705882 0 serum_phospholipids serum_scfa 0.296 0.407 no no no no no no 20:3/18:0-PI+blood butyric acid C4+blood 0 -0.5 0 serum_phospholipids serum_scfa 0.289 0.407 no no no no no no 22:0/16:0-PE+blood butyric acid C4+blood 0 0 -0.475555556 serum_phospholipids serum_scfa 0.091 0.407 no no up no no no 5-HETE+blood butyric acid C4+blood 0 0 -0.442198142 serum_ARA serum_scfa 0.697 0.407 no no no no no no 9-HODE+blood butyric acid C4+blood 0 0.637254902 0 serum_ARA serum_scfa 0.297 0.407 no no no no no no Acetic acid+stool Butyric acid+stool 0.661506708 0.664335664 0.839920949 yes yes stool_scfa stool_scfa 0.0656 0.102 dn no no dn no no Alcoholism Butyric acid+stool 0 0 -0.451157538 yes kegg stool_scfa NA 0.102 no no no dn no no Blautia Butyric acid+stool -0.506707946 0 0 acetate-producing yes Genus stool_scfa 1.36E-05 0.102 up dn dn dn no no Butyricicoccus Butyric acid+stool 0 0 0.543750985 butyrate-producing yes Genus stool_scfa 0.852 0.102 no no no dn no no Butyricimonas Butyric acid+stool 0 -0.652602405 0 butyrate-producing yes Genus stool_scfa 0.17 0.102 no no no dn no no Cell cycle Butyric acid+stool 0.585139319 0 0 yes kegg stool_scfa NA 0.102 no no no dn no no Chemokine signaling pathway Butyric acid+stool -0.481940144 0 0 yes kegg stool_scfa NA 0.102 no no no dn no no Clostridium Butyric acid+stool -0.628814167 0 -0.469986125 yes Genus stool_scfa 0.925 0.102 no no no dn no no Clostridium Butyric acid+stool -0.628814167 0 0.429948123 yes Genus stool_scfa 0.925 0.102 no no no dn no no Coprococcus Butyric acid+stool 0 0 0.536561265 butyrate-producing yes Genus stool_scfa 0.612 0.102 no no no dn no no Epithelial cell signaling in Helicobacter pylori infection Butyric acid+stool -0.484004128 0 0 yes kegg stool_scfa NA 0.102 no no no dn no no Faecalibacterium Butyric acid+stool 0.504643963 0 0 butyrate-producing yes Genus stool_scfa 0.0039 0.102 no dn dn dn no no Glioma Butyric acid+stool 0 -0.763636364 0 yes kegg stool_scfa NA 0.102 no no no dn no no Glucagon signaling pathway Butyric acid+stool 0.59752322 0 0 yes kegg stool_scfa NA 0.102 no no no dn no no Long-term potentiation Butyric acid+stool 0.473684211 0 0 yes kegg stool_scfa NA 0.102 no no up dn no no Lysosome Butyric acid+stool -0.475748194 0 0 yes kegg stool_scfa NA 0.102 no no no dn no no Mineral absorption Butyric acid+stool 0 0.654545455 0 yes kegg stool_scfa NA 0.102 no no no dn no no Mitophagy - animal Butyric acid+stool 0 0.754545455 0 yes kegg stool_scfa NA 0.102 no no no dn no no Neutrophil extracellular trap formation Butyric acid+stool -0.533539732 0 0 yes kegg stool_scfa NA 0.102 no no no dn no no Osteoclast differentiation Butyric acid+stool -0.50877193 0 0 yes kegg stool_scfa NA 0.102 no no no dn no no Pancreatic cancer Butyric acid+stool 0 -0.645454545 0 yes kegg stool_scfa NA 0.102 no no no dn no no Pathogenic Escherichia coli infection Butyric acid+stool -0.469556244 0 0 yes kegg stool_scfa NA 0.102 no no no dn no no Pathways in cancer Butyric acid+stool 0 0 -0.444381705 yes kegg stool_scfa NA 0.102 no no no dn no no Phosphatidylinositol signaling system Butyric acid+stool 0 -0.618181818 0 yes kegg stool_scfa NA 0.102 no no no dn no no Protein processing in endoplasmic reticulum Butyric acid+stool 0.547987616 0 0 yes kegg stool_scfa NA 0.102 no no no dn no no Purine metabolism Butyric acid+stool 0.519091847 0 0 yes kegg stool_scfa NA 0.102 no no no dn no no Shigellosis Butyric acid+stool 0 0.772727273 0 yes kegg stool_scfa NA 0.102 no no no dn no no Thyroid hormone synthesis Butyric acid+stool 0.50877193 0 0 yes kegg stool_scfa NA 0.102 no no no dn no no Ubiquitin mediated proteolysis Butyric acid+stool 0 0.754545455 0 yes kegg stool_scfa NA 0.102 no no no dn no no ¦Ø-MCA+stool Butyric acid+stool -0.498497246 0 0 yes stool_bileacids stool_scfa 0.919 0.102 no no no dn no no Wautersiella Butyricicoccus 0.443634386 0 0 butyrate-producing Genus Genus 0.289 0.852 no no no no no no 15-HETE+blood C-peptide 0 0 -0.674346986 serum_ARA DM-assocaited hormones 0.819 0.228 no no no no no no 16:0/20:3-PC+blood C-peptide 0 0 0.44 serum_phospholipids DM-assocaited hormones 5.43E-06 0.228 no up up no no no 16:0/20:5-PC+blood C-peptide 0 -0.485294118 0 serum_phospholipids DM-assocaited hormones 0.628 0.228 no no no no no no 16:0/22:6-PC+blood C-peptide 0 -0.495098039 0 serum_phospholipids DM-assocaited hormones 4.53E-05 0.228 no up up no no no 18:0-LPA+blood C-peptide 0 0 0.493043478 serum_phospholipids DM-assocaited hormones 0.0725 0.228 no dn no no no no 18:1/18:1-PC+blood C-peptide 0 0 0.448695652 serum_phospholipids DM-assocaited hormones 1.34E-05 0.228 no up up no no no 18:2-LPA+blood C-peptide 0 0 0.41826087 serum_phospholipids DM-assocaited hormones 0.00684 0.228 dn no up no no no 20:1-LPA+blood C-peptide 0 0 0.416521739 serum_phospholipids DM-assocaited hormones 0.0187 0.228 dn dn no no no no 20:3n6+blood C-peptide 0 0.544117647 0 serum_fattyacid DM-assocaited hormones 0.0884 0.228 up no no no no no ACA+stool C-peptide 0.50424075 0 0 stool_bileacids DM-assocaited hormones 0.417 0.228 no no no no no no Aldosterone synthesis and secretion C-peptide 0.587803501 0 0 kegg DM-assocaited hormones NA 0.228 no up up no no no Amphetamine addiction C-peptide 0.577639752 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Anaerostipes C-peptide -0.427626531 0 0 butyrate-producing Genus DM-assocaited hormones 0.568 0.228 no no no no no no Antigen processing and presentation C-peptide -0.639751553 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Arginine and proline metabolism C-peptide -0.611518916 0 0 kegg DM-assocaited hormones NA 0.228 no up no no no no Bifidobacterium C-peptide 0 0.42004457 0 acetate-producing Genus DM-assocaited hormones 0.105 0.228 no dn no no no no CDCA+stool C-peptide 0 0.587412587 0 stool_bileacids DM-assocaited hormones 0.663 0.228 no no no no no no Chemical carcinogenesis - receptor activation C-peptide 0.588932806 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Choline+blood C-peptide 0 0 0.45826087 serum_choline DM-assocaited hormones 0.0395 0.228 no up no no no no Collinsella C-peptide 0 0.404793989 0 Genus DM-assocaited hormones 0.128 0.228 no no no no no no Cushing syndrome C-peptide 0.658949746 0 0 kegg DM-assocaited hormones NA 0.228 no no up no no no DCA+blood C-peptide -0.471620227 0 0 serum_bileacids DM-assocaited hormones 0.122 0.228 no no no no no no DMG+blood C-peptide 0 0 0.455652174 serum_choline DM-assocaited hormones 0.909 0.228 no no no no no no Endocrine resistance C-peptide 0.648785997 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Epstein-Barr virus infection C-peptide -0.570863919 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Fc gamma R-mediated phagocytosis C-peptide -0.452286844 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no GABAergic synapse C-peptide -0.46809712 0 0 kegg DM-assocaited hormones NA 0.228 no up up no no no Gap junction C-peptide 0.450028233 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no GCDCA+stool C-peptide 0.508823529 0.727272727 0 yes stool_bileacids DM-assocaited hormones 0.0471 0.228 no dn no no no no GnRH signaling pathway C-peptide 0.431959345 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no "Growth hormone synthesis, secretion and action" C-peptide 0.435347261 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no HDCA+stool C-peptide 0 0 -0.487012987 stool_bileacids DM-assocaited hormones 0.176 0.228 no no no no no no Herpes simplex virus 1 infection C-peptide -0.599096556 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Human cytomegalovirus infection C-peptide -0.560700169 0 0 kegg DM-assocaited hormones NA 0.228 no no dn no no no Human immunodeficiency virus 1 infection C-peptide -0.581027668 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Human papillomavirus infection C-peptide 0 0.459486166 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Human T-cell leukemia virus 1 infection C-peptide -0.605872388 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no IL-8 C-peptide 0 0 -0.540229885 serum_cytokines DM-assocaited hormones 0.579 0.228 no no no no no no Inflammatory mediator regulation of TRP channels C-peptide 0.4432524 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no IP-10 C-peptide 0 0.490909091 0 serum_cytokines DM-assocaited hormones 0.394 0.228 no no no no no no L-Isoleucine+blood C-peptide 0 0 0.486086957 yes serum_aminoacids DM-assocaited hormones 5.47E-06 0.228 up up no no no no L-Leucine+blood C-peptide 0 0 0.486956522 yes serum_aminoacids DM-assocaited hormones 3.22E-05 0.228 up up no no no no L-Phenylalanine+blood C-peptide 0 0.593137255 0 yes serum_aminoacids DM-assocaited hormones 0.0103 0.228 up up no no no no L-Proline+blood C-peptide 0 0.681372549 0 yes serum_aminoacids DM-assocaited hormones 0.00265 0.228 up up no no no no L-Tryptophan+blood C-peptide 0 0.693627451 0 serum_aminoacids DM-assocaited hormones 0.164 0.228 no no no no no no L-Tyrosine+blood C-peptide 0 0.669117647 0.446086957 yes serum_aminoacids DM-assocaited hormones 0.00913 0.228 up up no no no no LCA+stool C-peptide 0 0 -0.475324675 stool_bileacids DM-assocaited hormones 0.314 0.228 no no no no no no Long-term depression C-peptide 0.444381705 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Long-term potentiation C-peptide 0 -0.470355731 0 kegg DM-assocaited hormones NA 0.228 no no up no no no Melanogenesis C-peptide 0.541501976 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Morphine addiction C-peptide 0.427442123 0 0 kegg DM-assocaited hormones NA 0.228 no up up no no no n6/n3+blood C-peptide 0 0.485294118 0 serum_fattyacid DM-assocaited hormones 0.226 0.228 no no no no no no Neutrophil extracellular trap formation C-peptide -0.489553924 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no NOD-like receptor signaling pathway C-peptide -0.526821005 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Odoribacter C-peptide -0.481440095 0 0 butyrate-producing Genus DM-assocaited hormones 0.798 0.228 no no no no no no Olfactory transduction C-peptide -0.445511011 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Oscillospira C-peptide 0.461462451 0 0 LPS-producing Genus DM-assocaited hormones 0.62 0.228 no no no no no no Osteoclast differentiation C-peptide -0.438735178 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Pancreatic secretion C-peptide 0.457933371 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Parabacteroides C-peptide 0 -0.565217391 0 Genus DM-assocaited hormones 4.19E-05 0.228 no up up no no no "Parathyroid hormone synthesis, secretion and action" C-peptide 0 0 -0.416109626 kegg DM-assocaited hormones NA 0.228 no no no no no no Peroxisome C-peptide -0.61038961 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Phenylacetic acid+stool C-peptide 0 -0.622377622 0 stool_cometabolism DM-assocaited hormones 0.785 0.228 no no no no no no Prolactin signaling pathway C-peptide 0 0.510869565 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Proteasome C-peptide -0.429700734 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no Roseburia C-peptide 0 0.54011743 0 butyrate-producing Genus DM-assocaited hormones 0.495 0.228 no no no no no no Ruminococcus C-peptide 0.617588933 0 0 acetate-producing Genus DM-assocaited hormones 0.335 0.228 no no no no no no Systemic lupus erythematosus C-peptide -0.476002259 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no total_stool_scfa+stool C-peptide 0 -0.713286713 0 stool_scfa DM-assocaited hormones 0.0534 0.228 dn no up no no no Valine+blood C-peptide 0 0 0.563478261 yes serum_aminoacids DM-assocaited hormones 1.22E-06 0.228 up up no no no no Wnt signaling pathway C-peptide 0.426312818 0 0 kegg DM-assocaited hormones NA 0.228 no no no no no no 2-Oxocarboxylic acid metabolism C-type lectin receptor signaling pathway -0.690434783 -0.572134387 -0.408751609 kegg kegg NA NA no no no no no no Adherens junction C-type lectin receptor signaling pathway -0.413913043 -0.566205534 -0.455598456 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes C-type lectin receptor signaling pathway 0 -0.565217391 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" C-type lectin receptor signaling pathway 0.485217391 0.696640316 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism C-type lectin receptor signaling pathway -0.451304348 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis C-type lectin receptor signaling pathway -0.420869565 -0.489130435 0 kegg kegg NA NA no no no no no no Antifolate resistance C-type lectin receptor signaling pathway -0.459130435 -0.503952569 0 kegg kegg NA NA no no no no no no Apelin signaling pathway C-type lectin receptor signaling pathway 0 -0.652173913 0 kegg kegg NA NA no no no no no no Apoptosis C-type lectin receptor signaling pathway 0 0.858695652 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism C-type lectin receptor signaling pathway -0.545217391 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism C-type lectin receptor signaling pathway 0 0.751976285 0.591248391 kegg kegg NA NA no up no no no no Arginine biosynthesis C-type lectin receptor signaling pathway 0.440869565 0.688735178 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism C-type lectin receptor signaling pathway 0 -0.438735178 0 kegg kegg NA NA no no no no no no Autophagy - animal C-type lectin receptor signaling pathway 0.791304348 0.820158103 0.451480051 kegg kegg NA NA no no no no no no Autophagy - other C-type lectin receptor signaling pathway 0.577391304 0 0 kegg kegg NA NA no no no no no no Axon guidance C-type lectin receptor signaling pathway 0.54173913 0 0 kegg kegg NA NA no up up no no no Basal transcription factors C-type lectin receptor signaling pathway 0 -0.530632411 0 kegg kegg NA NA no no no no no no Base excision repair C-type lectin receptor signaling pathway 0 -0.508893281 -0.484942085 kegg kegg NA NA no no no no no no beta-Alanine metabolism C-type lectin receptor signaling pathway -0.623478261 0 -0.596396396 kegg kegg NA NA no no no no no no Biosynthesis of amino acids C-type lectin receptor signaling pathway 0 0.572134387 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors C-type lectin receptor signaling pathway -0.725217391 -0.684782609 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids C-type lectin receptor signaling pathway -0.547826087 -0.43083004 -0.612870013 kegg kegg NA NA no no no no no no Butanoate metabolism C-type lectin receptor signaling pathway -0.666956522 -0.72826087 -0.656628057 kegg kegg NA NA no no no no no no cAMP signaling pathway C-type lectin receptor signaling pathway 0.552173913 0.618577075 0.55006435 yes kegg kegg NA NA no up up no no no Carbon metabolism C-type lectin receptor signaling pathway -0.520869565 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction C-type lectin receptor signaling pathway 0 -0.587944664 0 kegg kegg NA NA no no up no no no Cell adhesion molecules C-type lectin receptor signaling pathway 0 0.553359684 0 kegg kegg NA NA no no no no no no Cell cycle C-type lectin receptor signaling pathway 0 -0.679841897 0 kegg kegg NA NA no no no no no no Cellular senescence C-type lectin receptor signaling pathway 0 0.694664032 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway C-type lectin receptor signaling pathway 0.640869565 0.663043478 0.496010296 kegg kegg NA NA no no no no no no Chemokine signaling pathway C-type lectin receptor signaling pathway 0.423478261 0.653162055 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) C-type lectin receptor signaling pathway -0.655652174 -0.75 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades C-type lectin receptor signaling pathway 0 0.54743083 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism C-type lectin receptor signaling pathway -0.406086957 -0.706521739 -0.565250965 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction C-type lectin receptor signaling pathway 0 0 -0.458429858 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway 0 0.690711462 0.438352638 kegg kegg NA NA no no no no no no DNA replication C-type lectin receptor signaling pathway 0 -0.829051383 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 C-type lectin receptor signaling pathway 0 -0.833003953 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes C-type lectin receptor signaling pathway -0.573043478 -0.722332016 0 kegg kegg NA NA no no no no no no ECM-receptor interaction C-type lectin receptor signaling pathway -0.516521739 -0.484189723 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance C-type lectin receptor signaling pathway 0 -0.490118577 0 kegg kegg NA NA no no no no no no Endocytosis C-type lectin receptor signaling pathway 0 0.572134387 0 kegg kegg NA NA no no no no no no ErbB signaling pathway C-type lectin receptor signaling pathway 0.592173913 0.514822134 0 kegg kegg NA NA no no no no no no Ether lipid metabolism C-type lectin receptor signaling pathway 0 -0.548418972 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway C-type lectin receptor signaling pathway 0 -0.475296443 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis C-type lectin receptor signaling pathway 0.453043478 0.694664032 0.439382239 kegg kegg NA NA no no no no no no Fatty acid degradation C-type lectin receptor signaling pathway 0 0.436758893 0 kegg kegg NA NA no no no no no no Fatty acid elongation C-type lectin receptor signaling pathway -0.53826087 0 -0.582496782 kegg kegg NA NA no no no no no no Focal adhesion C-type lectin receptor signaling pathway -0.517391304 -0.574110672 -0.517117117 kegg kegg NA NA no up up no no no FoxO signaling pathway C-type lectin receptor signaling pathway 0 0.453557312 0 kegg kegg NA NA no no no no no no Galactose metabolism C-type lectin receptor signaling pathway 0 0.466403162 0 kegg kegg NA NA no no no no no no Gap junction C-type lectin receptor signaling pathway -0.416521739 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism C-type lectin receptor signaling pathway -0.496521739 -0.700592885 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" C-type lectin receptor signaling pathway -0.613043478 -0.527667984 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis C-type lectin receptor signaling pathway -0.615652174 -0.511857708 -0.443243243 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate C-type lectin receptor signaling pathway 0.54 0.73715415 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin C-type lectin receptor signaling pathway -0.654782609 -0.421936759 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series C-type lectin receptor signaling pathway 0 -0.517786561 -0.446332046 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series C-type lectin receptor signaling pathway 0.426086957 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism C-type lectin receptor signaling pathway 0 0.716403162 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway C-type lectin receptor signaling pathway 0 -0.445652174 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway C-type lectin receptor signaling pathway 0 -0.477272727 0 kegg kegg NA NA no no no no no no Hippo signaling pathway C-type lectin receptor signaling pathway -0.608695652 -0.623517787 -0.553153153 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species C-type lectin receptor signaling pathway 0.496521739 0.62944664 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species C-type lectin receptor signaling pathway 0 0 -0.46975547 kegg kegg NA NA no no no no no no Lysosome C-type lectin receptor signaling pathway 0.426086957 0.528656126 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 C-type lectin receptor signaling pathway 0 -0.794466403 -0.403861004 kegg kegg NA NA no no no no no no Mismatch repair C-type lectin receptor signaling pathway -0.547826087 -0.785573123 -0.592792793 kegg kegg NA NA no no no no no no mRNA surveillance pathway C-type lectin receptor signaling pathway 0 -0.481225296 0 kegg kegg NA NA no no no no no no mTOR signaling pathway C-type lectin receptor signaling pathway 0 -0.459486166 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis C-type lectin receptor signaling pathway 0 -0.753952569 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction C-type lectin receptor signaling pathway 0 0.451581028 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation C-type lectin receptor signaling pathway 0 0.504940711 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway C-type lectin receptor signaling pathway 0.536521739 0.863636364 0.847619048 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism C-type lectin receptor signaling pathway 0.44 0.707509881 0.491891892 kegg kegg NA NA no no no no no no Nitrogen metabolism C-type lectin receptor signaling pathway 0.407826087 0.650197628 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway C-type lectin receptor signaling pathway 0.44 0.927865613 0 kegg kegg NA NA no no no no no no Non-homologous end-joining C-type lectin receptor signaling pathway -0.646086957 -0.53458498 -0.601029601 kegg kegg NA NA no no no no no no Notch signaling pathway C-type lectin receptor signaling pathway 0.536521739 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair C-type lectin receptor signaling pathway 0 -0.81916996 -0.623423423 kegg kegg NA NA no no no no no no One carbon pool by folate C-type lectin receptor signaling pathway -0.499130435 -0.833003953 -0.434749035 kegg kegg NA NA no no no no no no Oocyte meiosis C-type lectin receptor signaling pathway 0 -0.625494071 0 kegg kegg NA NA no no no no no no Osteoclast differentiation C-type lectin receptor signaling pathway 0.489565217 0.872529644 0.67001287 kegg kegg NA NA no no no no no no Oxidative phosphorylation C-type lectin receptor signaling pathway 0 -0.611660079 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis C-type lectin receptor signaling pathway 0 0.601778656 0 kegg kegg NA NA no no dn no no no Paraprevotella C-type lectin receptor signaling pathway -0.477190089 0 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions C-type lectin receptor signaling pathway -0.682608696 -0.735177866 -0.405148005 kegg kegg NA NA no no no no no no Pentose phosphate pathway C-type lectin receptor signaling pathway 0 0.539525692 0 kegg kegg NA NA no no no no no no Peroxisome C-type lectin receptor signaling pathway 0 0.562252964 0 kegg kegg NA NA no no no no no no Phagosome C-type lectin receptor signaling pathway 0 0.542490119 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism C-type lectin receptor signaling pathway -0.820869565 -0.7243083 -0.580952381 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway C-type lectin receptor signaling pathway 0 0.615612648 0 kegg kegg NA NA no up up no no no Platelet activation C-type lectin receptor signaling pathway -0.53826087 -0.528656126 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism C-type lectin receptor signaling pathway -0.572173913 -0.462450593 0 kegg kegg NA NA no no no no no no PPAR signaling pathway C-type lectin receptor signaling pathway 0.435652174 0.809288538 0.553667954 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis C-type lectin receptor signaling pathway -0.597391304 -0.479249012 -0.449163449 kegg kegg NA NA no no no no no no Propanoate metabolism C-type lectin receptor signaling pathway 0 -0.668972332 -0.52972973 kegg kegg NA NA no no no no no no Proteasome C-type lectin receptor signaling pathway 0 -0.545454545 0 kegg kegg NA NA no no no no no no Protein export C-type lectin receptor signaling pathway 0 -0.621541502 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum C-type lectin receptor signaling pathway -0.444347826 -0.707509881 0 kegg kegg NA NA no no no no no no Purine metabolism C-type lectin receptor signaling pathway -0.420869565 -0.492094862 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism C-type lectin receptor signaling pathway -0.428695652 -0.802371542 0 kegg kegg NA NA no no no no no no Pyruvate metabolism C-type lectin receptor signaling pathway -0.524347826 -0.763833992 -0.62033462 kegg kegg NA NA no no no no no no Ras signaling pathway C-type lectin receptor signaling pathway 0 -0.696640316 0 yes kegg kegg NA NA no up up no no no Renin-angiotensin system C-type lectin receptor signaling pathway 0 0.638339921 0 kegg kegg NA NA no no no no no no Retinol metabolism C-type lectin receptor signaling pathway -0.491304348 -0.695652174 -0.466409266 kegg kegg NA NA no no no no no no Ribosome C-type lectin receptor signaling pathway 0 -0.561264822 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes C-type lectin receptor signaling pathway 0 -0.626482213 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway C-type lectin receptor signaling pathway 0.873913043 0.884387352 0.87001287 kegg kegg NA NA no no no no no no RNA degradation C-type lectin receptor signaling pathway 0 -0.60770751 0 kegg kegg NA NA no no no no no no RNA polymerase C-type lectin receptor signaling pathway 0 -0.68972332 -0.409009009 kegg kegg NA NA no no no no no no Sarcina C-type lectin receptor signaling pathway 0 0.444554224 0 Genus kegg 0.0703 NA no no no no no no Signaling pathways regulating pluripotency of stem cells C-type lectin receptor signaling pathway 0.52173913 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport C-type lectin receptor signaling pathway 0 0.522727273 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway C-type lectin receptor signaling pathway 0.675652174 0.688735178 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism C-type lectin receptor signaling pathway 0 0.599802372 0 kegg kegg NA NA no no no no no no Steroid biosynthesis C-type lectin receptor signaling pathway 0 -0.730237154 -0.663577864 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis C-type lectin receptor signaling pathway -0.488695652 -0.68083004 0 kegg kegg NA NA no no no no no no Sulfur metabolism C-type lectin receptor signaling pathway -0.5 -0.455533597 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies C-type lectin receptor signaling pathway -0.44 -0.752964427 -0.548777349 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis C-type lectin receptor signaling pathway 0 -0.432806324 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway C-type lectin receptor signaling pathway 0 -0.561264822 0 kegg kegg NA NA no no no no no no Thiamine metabolism C-type lectin receptor signaling pathway 0 -0.566205534 0 kegg kegg NA NA no no no no no no Tight junction C-type lectin receptor signaling pathway -0.482608696 -0.505928854 -0.45971686 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway C-type lectin receptor signaling pathway 0.763478261 0.958498024 0.741570142 yes kegg kegg NA NA no no no no no no Tryptophan metabolism C-type lectin receptor signaling pathway -0.675652174 -0.592885375 0 kegg kegg NA NA no up no no no no Tyrosine metabolism C-type lectin receptor signaling pathway -0.827826087 -0.837944664 -0.801801802 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis C-type lectin receptor signaling pathway -0.602608696 -0.744071146 -0.555212355 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis C-type lectin receptor signaling pathway 0 -0.496047431 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" C-type lectin receptor signaling pathway -0.626956522 -0.760869565 -0.642213642 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis C-type lectin receptor signaling pathway 0 -0.589920949 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction C-type lectin receptor signaling pathway 0 -0.683794466 0 kegg kegg NA NA no no no no no no VEGF signaling pathway C-type lectin receptor signaling pathway 0.708695652 0.598814229 0 kegg kegg NA NA no no no no no no Wnt signaling pathway C-type lectin receptor signaling pathway 0 -0.677865613 0 kegg kegg NA NA no no no no no no 12-ketoDCA+blood CA+blood 0.509987079 0 0 serum_bileacids serum_bileacids 0.517 0.606 no no no no no no 14:0/20:4-PC+blood CA+blood 0 0.605763449 0 serum_phospholipids serum_bileacids 0.486 0.606 no no no no no no 16:0/16:0-PC+blood CA+blood 0 -0.491722962 0 serum_phospholipids serum_bileacids 0.00079 0.606 no up up no no no 16:0/18:1-PC+blood CA+blood 0 -0.50398538 0 serum_phospholipids serum_bileacids 6.15E-07 0.606 up up up no no no 16:0/18:2-PC+blood CA+blood 0 -0.488044236 0 serum_phospholipids serum_bileacids 3.24E-06 0.606 no up up no no no 16:0/20:5-PC+blood CA+blood 0 0 0.468956447 serum_phospholipids serum_bileacids 0.628 0.606 no no no no no no 16:0/20:5-PG+blood CA+blood -0.47461455 0 0 serum_phospholipids serum_bileacids 0.00656 0.606 no up no no no no 18:0/16:0-PC+blood CA+blood 0 -0.535867667 0 serum_phospholipids serum_bileacids 9.64E-07 0.606 up up up no no no 18:0/20:3-PI+blood CA+blood -0.610003804 0 0 serum_phospholipids serum_bileacids 0.377 0.606 no no no no no no 18:0/20:4-PI+blood CA+blood -0.544565665 0 0 serum_phospholipids serum_bileacids 0.167 0.606 no no no no no no 18:0/22:6-PA+blood CA+blood -0.464084275 0 0 serum_phospholipids serum_bileacids 0.22 0.606 no no no no no no 18:1-LPE+blood CA+blood 0.473862388 0 0 serum_phospholipids serum_bileacids 0.117 0.606 no no no no no no 18:1/16:0-PC+blood CA+blood 0 -0.492949204 0 serum_phospholipids serum_bileacids 2.43E-05 0.606 no up up no no no 18:1/18:0-PS+blood CA+blood -0.574652165 0 0 serum_phospholipids serum_bileacids 0.193 0.606 no no no no no no 18:1/18:1-PG+blood CA+blood -0.523505114 0 0 serum_phospholipids serum_bileacids 0.00352 0.606 no up up no no no 18:1/20:3-PC+blood CA+blood 0 0 -0.459350902 serum_phospholipids serum_bileacids 0.00872 0.606 no up up no no no 18:1/22:6-PE+blood CA+blood -0.451297512 -0.492949204 0 serum_phospholipids serum_bileacids 0.0047 0.606 no up no no no no 18:1+blood CA+blood -0.466340763 0 -0.417498169 yes serum_fattyacid serum_bileacids 0.00202 0.606 up no dn no no no 18:2-LPE+blood CA+blood 0.484392663 0 0 serum_phospholipids serum_bileacids 0.112 0.606 no no no no no no 18:2/18:1-PC+blood CA+blood 0 0.620478351 0 serum_phospholipids serum_bileacids 2.30E-05 0.606 dn up up no no no 18:2/18:2-PC+blood CA+blood 0 0.658491847 0 serum_phospholipids serum_bileacids 1.98E-05 0.606 dn up up no no no 18:2/20:4-PC+blood CA+blood -0.449041025 0 0 serum_phospholipids serum_bileacids 0.0145 0.606 no no up no no no 18:3-LPC+blood CA+blood 0.47461455 0.49049672 0 serum_phospholipids serum_bileacids 0.147 0.606 no no no no no no 18:3/18:2-PC+blood CA+blood 0 0.581238613 0 serum_phospholipids serum_bileacids 0.0394 0.606 no no up no no no 18:3n6+blood CA+blood 0 0.505211622 0 serum_fattyacid serum_bileacids 0.0463 0.606 up no dn no no no 2-methyl-butyric acid m-C4+blood CA+blood 0 0 -0.440825922 serum_scfa serum_bileacids 0.262 0.606 no no no no no no 20:0/20:5-PC+blood CA+blood -0.72809332 0 0 serum_phospholipids serum_bileacids 0.882 0.606 no no no no no no 20:1/20:4-PC+blood CA+blood 0 -0.483139269 0 serum_phospholipids serum_bileacids 0.0419 0.606 no no up no no no 20:1/20:4-PE+blood CA+blood -0.48063185 0 0 serum_phospholipids serum_bileacids 0.0042 0.606 up up no no no no 20:2+blood CA+blood 0 0 -0.668614569 serum_fattyacid serum_bileacids 0.478 0.606 no no no no no no 20:3/18:0-PI+blood CA+blood -0.494922938 0 0 serum_phospholipids serum_bileacids 0.289 0.606 no no no no no no 20:4/16:0-PE+blood CA+blood 0 0.500306654 0 serum_phospholipids serum_bileacids 0.00529 0.606 no up up no no no 20:5/18:0-PC+blood CA+blood -0.472358063 0 0 serum_phospholipids serum_bileacids 3.97E-06 0.606 no up up no no no 20:5n3+blood CA+blood 0 0 0.516984174 serum_fattyacid serum_bileacids 0.988 0.606 no no no no no no 24:0+blood CA+blood -0.497179426 0 0 serum_fattyacid serum_bileacids 0.034 0.606 dn no up no no no acetic acid C2+blood CA+blood -0.533283227 0 0 serum_scfa serum_bileacids 0.000193 0.606 up dn no no no no Acute myeloid leukemia CA+blood 0 -0.522443114 0 kegg serum_bileacids NA 0.606 no no no no no no Adrenergic signaling in cardiomyocytes CA+blood 0 0.812362251 0.550583254 kegg serum_bileacids NA 0.606 no no up no no no AGE-RAGE signaling pathway in diabetic complications CA+blood 0 -0.657836823 0 kegg serum_bileacids NA 0.606 no no no no no no Akkermansia CA+blood -0.538053088 0 0 acetate-producing Genus serum_bileacids 0.23 0.606 no no no no no no Aldosterone synthesis and secretion CA+blood 0 0.722590335 0.612359777 kegg serum_bileacids NA 0.606 no up up no no no Allograft rejection CA+blood 0 -0.644591786 0 kegg serum_bileacids NA 0.606 no no no no no no Alzheimer disease CA+blood 0 0.746137067 0.400775188 kegg serum_bileacids NA 0.606 no no no no no no Amoebiasis CA+blood 0 -0.531273139 0 kegg serum_bileacids NA 0.606 no no no no no no Amphetamine addiction CA+blood 0 0.760853775 0.530505885 kegg serum_bileacids NA 0.606 no no no no no no AMPK signaling pathway CA+blood 0.458973278 0.788815519 0 kegg serum_bileacids NA 0.606 no no no no no no Amyotrophic lateral sclerosis CA+blood 0 0.746137067 0.491123352 kegg serum_bileacids NA 0.606 no no no no no no Apelin signaling pathway CA+blood 0 0.743193726 0 kegg serum_bileacids NA 0.606 no no no no no no Apoptosis CA+blood 0 -0.559234883 0 kegg serum_bileacids NA 0.606 no no no no no no Arginine and proline metabolism CA+blood 0 -0.626931737 0 kegg serum_bileacids NA 0.606 no up no no no no Autoimmune thyroid disease CA+blood 0 -0.644591786 0 kegg serum_bileacids NA 0.606 no no no no no no Betaine+blood CA+blood 0 0 -0.446314805 serum_choline serum_bileacids 0.857 0.606 no no no no no no Bifidobacterium CA+blood -0.490594432 0 0 acetate-producing Genus serum_bileacids 0.105 0.606 no dn no no no no Biosynthesis of amino acids CA+blood 0 -0.61221503 -0.485717906 kegg serum_bileacids NA 0.606 no no no no no no Bladder cancer CA+blood 0 -0.618101713 0 kegg serum_bileacids NA 0.606 no no no no no no Blautia CA+blood -0.485896988 0 0 acetate-producing Genus serum_bileacids 1.36E-05 0.606 up dn dn no no no CA+stool CA+blood 0 0 0.525772664 stool_bileacids serum_bileacids 0.827 0.606 no no no no no no Calcium signaling pathway CA+blood 0 0.51361309 0.505023069 kegg serum_bileacids NA 0.606 no up up no no no Carbon metabolism CA+blood 0 0 -0.488806732 kegg serum_bileacids NA 0.606 no no no no no no Cardiac muscle contraction CA+blood 0 0.701986945 0.437068895 kegg serum_bileacids NA 0.606 no no up no no no Cell adhesion molecules CA+blood 0 -0.615158371 0 kegg serum_bileacids NA 0.606 no no no no no no Cellular senescence CA+blood 0 -0.582781615 0 kegg serum_bileacids NA 0.606 no no no no no no Central carbon metabolism in cancer CA+blood 0 0.520971443 0 kegg serum_bileacids NA 0.606 no no no no no no cGMP-PKG signaling pathway CA+blood 0 -0.597498322 0 kegg serum_bileacids NA 0.606 no no no no no no Chemokine signaling pathway CA+blood 0 -0.575423261 0 kegg serum_bileacids NA 0.606 no no no no no no Cocaine addiction CA+blood 0 0 0.406180634 kegg serum_bileacids NA 0.606 no no no no no no Coprococcus CA+blood 0 0 -0.555406356 butyrate-producing Genus serum_bileacids 0.612 0.606 no no no no no no Coronavirus disease - COVID-19 CA+blood 0 0.763797116 0 kegg serum_bileacids NA 0.606 no no no no no no Cortisol synthesis and secretion CA+blood 0 0 0.50270645 kegg serum_bileacids NA 0.606 no no up no no no Cushing syndrome CA+blood 0 0.663723506 0.491895558 kegg serum_bileacids NA 0.606 no no up no no no Cytokine-cytokine receptor interaction CA+blood 0 -0.563649895 0 kegg serum_bileacids NA 0.606 no no no no no no Diabetic cardiomyopathy CA+blood 0 0.734363701 0 kegg serum_bileacids NA 0.606 no no no no no no Dopaminergic synapse CA+blood 0 0.587196627 0.527417059 kegg serum_bileacids NA 0.606 no up no no no no EGFR tyrosine kinase inhibitor resistance CA+blood 0 0.800588885 0 kegg serum_bileacids NA 0.606 no no no no no no Endocytosis CA+blood 0 -0.606328347 0 kegg serum_bileacids NA 0.606 no no no no no no Epithelial cell signaling in Helicobacter pylori infection CA+blood 0 -0.507726407 0 kegg serum_bileacids NA 0.606 no no no no no no Fc epsilon RI signaling pathway CA+blood 0 -0.67255353 0 kegg serum_bileacids NA 0.606 no no no no no no Fc gamma R-mediated phagocytosis CA+blood -0.479157571 -0.669610189 -0.50038983 kegg serum_bileacids NA 0.606 no no no no no no GABAergic synapse CA+blood 0 -0.551876529 0 kegg serum_bileacids NA 0.606 no up up no no no GCDCA+stool CA+blood 0 0 0.551530979 yes stool_bileacids serum_bileacids 0.0471 0.606 no dn no no no no Glucagon signaling pathway CA+blood 0 0.79028719 0.600776679 kegg serum_bileacids NA 0.606 no no no no no no GnRH signaling pathway CA+blood 0 0.65342181 0.471818189 kegg serum_bileacids NA 0.606 no no no no no no Graft-versus-host disease CA+blood 0 -0.644591786 0 kegg serum_bileacids NA 0.606 no no no no no no HIF-1 signaling pathway CA+blood 0 0.722590335 0 kegg serum_bileacids NA 0.606 no no no no no no Human papillomavirus infection CA+blood 0 -0.59308331 0 kegg serum_bileacids NA 0.606 no no no no no no Huntington disease CA+blood 0 0.746137067 0 kegg serum_bileacids NA 0.606 no no no no no no IL-17 signaling pathway CA+blood 0 -0.562178224 0 kegg serum_bileacids NA 0.606 no no no no no no Inflammatory mediator regulation of TRP channels CA+blood 0 0.744665397 0.547494428 kegg serum_bileacids NA 0.606 no no no no no no Influenza A CA+blood 0 -0.559234883 0 kegg serum_bileacids NA 0.606 no no no no no no Insulin secretion CA+blood 0 0 0.477995841 yes kegg serum_bileacids NA 0.606 no up up no no no Insulin signaling pathway CA+blood 0 0.77115547 0 kegg serum_bileacids NA 0.606 no no no no no no L-Tryptophan+stool CA+blood -0.565934066 0 0 stool_cometabolism serum_bileacids 0.557 0.606 no no no no no no Legionellosis CA+blood 0 0.544518175 0 kegg serum_bileacids NA 0.606 no no no no no no Lipid and atherosclerosis CA+blood 0 -0.740250384 0 kegg serum_bileacids NA 0.606 no no no no no no Long-term potentiation CA+blood 0 0.501839724 0 kegg serum_bileacids NA 0.606 no no up no no no Lysosome CA+blood 0 -0.678440213 0 kegg serum_bileacids NA 0.606 no no no no no no Melanogenesis CA+blood 0 0.65342181 0.444018754 kegg serum_bileacids NA 0.606 no no no no no no Mitophagy - animal CA+blood 0.499341865 0.713760311 0 kegg serum_bileacids NA 0.606 no no no no no no Morphine addiction CA+blood 0 0 0.457146265 kegg serum_bileacids NA 0.606 no up up no no no mRNA surveillance pathway CA+blood 0 0.63281842 0.5204672 kegg serum_bileacids NA 0.606 no no no no no no mTOR signaling pathway CA+blood 0 0.835908983 0 kegg serum_bileacids NA 0.606 no no no no no no Natural killer cell mediated cytotoxicity CA+blood 0 -0.547461517 0 kegg serum_bileacids NA 0.606 no no no no no no Neuroactive ligand-receptor interaction CA+blood 0 -0.669610189 0 kegg serum_bileacids NA 0.606 up up up no no no Neutrophil extracellular trap formation CA+blood 0 -0.706401957 0 kegg serum_bileacids NA 0.606 no no no no no no Nicotinate and nicotinamide metabolism CA+blood 0 -0.604856676 0 kegg serum_bileacids NA 0.606 no no no no no no NOD-like receptor signaling pathway CA+blood 0 -0.512141419 0 kegg serum_bileacids NA 0.606 no no no no no no Non-alcoholic fatty liver disease CA+blood 0 0.73142036 0.484173493 kegg serum_bileacids NA 0.606 no no no no no no nutriCA+stool CA+blood 0 0 0.519711884 stool_bileacids serum_bileacids 0.481 0.606 no no no no no no Olfactory transduction CA+blood -0.477402415 -0.591611639 0 kegg serum_bileacids NA 0.606 no no no no no no Osteoclast differentiation CA+blood 0 -0.610743359 0 kegg serum_bileacids NA 0.606 no no no no no no Oxidative phosphorylation CA+blood 0 0.704930287 0 kegg serum_bileacids NA 0.606 no no no no no no Pancreatic secretion CA+blood 0 0 0.422396971 kegg serum_bileacids NA 0.606 no no no no no no "Parathyroid hormone synthesis, secretion and action" CA+blood 0 0.816777263 0 kegg serum_bileacids NA 0.606 no no no no no no Parkinson disease CA+blood 0 0.749080409 0 kegg serum_bileacids NA 0.606 no no no no no no Pathogenic Escherichia coli infection CA+blood 0 -0.57247992 0 kegg serum_bileacids NA 0.606 no no no no no no Pathways of neurodegeneration - multiple diseases CA+blood 0 0.769683799 0 kegg serum_bileacids NA 0.606 no no no no no no Peroxisome CA+blood -0.46248359 -0.706401957 -0.416219319 kegg serum_bileacids NA 0.606 no no no no no no Pertussis CA+blood 0 -0.722590335 -0.412358286 kegg serum_bileacids NA 0.606 no no dn no no no Phagosome CA+blood 0 -0.656365152 0 kegg serum_bileacids NA 0.606 no no no no no no Phosphatidylinositol signaling system CA+blood 0 0 0.430119036 kegg serum_bileacids NA 0.606 no no no no no no Prion disease CA+blood 0 0.746137067 0 kegg serum_bileacids NA 0.606 no no no no no no Prolactin signaling pathway CA+blood 0 -0.504783065 0 kegg serum_bileacids NA 0.606 no no no no no no Protein processing in endoplasmic reticulum CA+blood 0 0.625460066 0 kegg serum_bileacids NA 0.606 no no no no no no Proteoglycans in cancer CA+blood 0.532689827 0.57395159 0 kegg serum_bileacids NA 0.606 no no no no no no Purine metabolism CA+blood 0 0.551876529 0 kegg serum_bileacids NA 0.606 no no no no no no Ras signaling pathway CA+blood 0 0 0.406180634 yes kegg serum_bileacids NA 0.606 no up up no no no Renin secretion CA+blood 0 0.562178224 0 kegg serum_bileacids NA 0.606 no no no no no no Retrograde endocannabinoid signaling CA+blood 0 0.568064907 0.459462884 kegg serum_bileacids NA 0.606 no no up no no no Rheumatoid arthritis CA+blood 0 -0.668138518 0 kegg serum_bileacids NA 0.606 no no no no no no Ribosome CA+blood 0 0.763797116 0 kegg serum_bileacids NA 0.606 no no no no no no Ribosome biogenesis in eukaryotes CA+blood 0 0.509198078 0 kegg serum_bileacids NA 0.606 no no no no no no RNA degradation CA+blood 0 0.588668298 0 kegg serum_bileacids NA 0.606 no no no no no no RNA transport CA+blood 0 0.762325446 0 kegg serum_bileacids NA 0.606 no no no no no no Salmonella infection CA+blood 0 -0.532744809 0 kegg serum_bileacids NA 0.606 no no no no no no Shigellosis CA+blood 0.464238746 0.569536578 0 kegg serum_bileacids NA 0.606 no no no no no no Spinocerebellar ataxia CA+blood 0 0.543046505 0 kegg serum_bileacids NA 0.606 no no no no no no Staphylococcus aureus infection CA+blood 0 -0.73142036 -0.505023069 kegg serum_bileacids NA 0.606 up no no no no no Systemic lupus erythematosus CA+blood 0 -0.754967092 -0.416219319 kegg serum_bileacids NA 0.606 no no no no no no Thermogenesis CA+blood 0 0.775570482 0 kegg serum_bileacids NA 0.606 no no no no no no Thyroid hormone synthesis CA+blood 0 0.578366602 0 kegg serum_bileacids NA 0.606 no no no no no no Toxoplasmosis CA+blood 0 -0.565121566 0 kegg serum_bileacids NA 0.606 no no no no no no Transcriptional misregulation in cancer CA+blood 0 -0.498896382 0 kegg serum_bileacids NA 0.606 no no no no no no Tuberculosis CA+blood 0 -0.700515274 -0.458690678 kegg serum_bileacids NA 0.606 no no dn no no no Type I diabetes mellitus CA+blood 0 -0.644591786 0 kegg serum_bileacids NA 0.606 no no no no no no Ubiquitin mediated proteolysis CA+blood 0.511627956 0.743193726 0 kegg serum_bileacids NA 0.606 no no no no no no Vascular smooth muscle contraction CA+blood 0 0.523914785 0 kegg serum_bileacids NA 0.606 no no no no no no Viral carcinogenesis CA+blood 0 -0.576894932 0 kegg serum_bileacids NA 0.606 no no no no no no Viral myocarditis CA+blood 0 -0.610743359 0 kegg serum_bileacids NA 0.606 no no no no no no Wnt signaling pathway CA+blood 0 0.519499773 0.435524482 kegg serum_bileacids NA 0.606 no no no no no no Yersinia infection CA+blood 0 -0.709345299 0 kegg serum_bileacids NA 0.606 no no no no no no 12-ketoDCA+stool CA+stool -0.525283798 0 0 stool_bileacids stool_bileacids 0.505 0.827 no no no no no no Aldosterone synthesis and secretion CA+stool -0.519091847 0 0 kegg stool_bileacids NA 0.827 no up up no no no Allograft rejection CA+stool 0 0.690909091 0.551665726 kegg stool_bileacids NA 0.827 no no no no no no Alzheimer disease CA+stool 0 0 0.556182947 kegg stool_bileacids NA 0.827 no no no no no no Amoebiasis CA+stool 0.469556244 0 0 kegg stool_bileacids NA 0.827 no no no no no no Amphetamine addiction CA+stool -0.678018576 0 0 kegg stool_bileacids NA 0.827 no no no no no no AMPK signaling pathway CA+stool 0 0 -0.465838509 kegg stool_bileacids NA 0.827 no no no no no no Amyotrophic lateral sclerosis CA+stool 0 0 0.579898363 kegg stool_bileacids NA 0.827 no no no no no no Antigen processing and presentation CA+stool 0.496388029 0 0.438735178 kegg stool_bileacids NA 0.827 no no no no no no Apoptosis CA+stool 0.609907121 0 0 kegg stool_bileacids NA 0.827 no no no no no no Arginine and proline metabolism CA+stool 0.492260062 0 0 kegg stool_bileacids NA 0.827 no up no no no no Asthma CA+stool 0 0.781818182 0 kegg stool_bileacids NA 0.827 no no no no no no Autoimmune thyroid disease CA+stool 0 0.690909091 0.551665726 kegg stool_bileacids NA 0.827 no no no no no no Bacterial invasion of epithelial cells CA+stool 0 0.618181818 0 kegg stool_bileacids NA 0.827 no no no no no no Bacteroides CA+stool 0.671826625 0 0 LPS-producing Genus stool_bileacids 0.000267 0.827 dn dn up no no no Bifidobacterium CA+stool 0 0.587412587 0 acetate-producing Genus stool_bileacids 0.105 0.827 no dn no no no no Biosynthesis of amino acids CA+stool 0.626418989 0 0 kegg stool_bileacids NA 0.827 no no no no no no Blautia CA+stool 0.479876161 0.636363636 0 acetate-producing Genus stool_bileacids 1.36E-05 0.827 up dn dn no no no Butyric acid+stool CA+stool -0.547987616 0 0 yes stool_scfa stool_bileacids 0.102 0.827 dn no no no no no Carbon metabolism CA+stool 0 0.818181818 0 kegg stool_bileacids NA 0.827 no no no no no no Cardiac muscle contraction CA+stool 0 0 0.561829475 kegg stool_bileacids NA 0.827 no no up no no no Cell adhesion molecules CA+stool 0.484004128 0.681818182 0.470355731 kegg stool_bileacids NA 0.827 no no no no no no Cell cycle CA+stool -0.523219814 0 0 kegg stool_bileacids NA 0.827 no no no no no no Cellular senescence CA+stool 0.655314757 0 0.604743083 kegg stool_bileacids NA 0.827 no no no no no no Central carbon metabolism in cancer CA+stool 0 0 -0.489553924 kegg stool_bileacids NA 0.827 no no no no no no cGMP-PKG signaling pathway CA+stool 0.506707946 0 0 kegg stool_bileacids NA 0.827 no no no no no no Chemical carcinogenesis - receptor activation CA+stool -0.502579979 -0.709090909 0 kegg stool_bileacids NA 0.827 no no no no no no Chemokine signaling pathway CA+stool 0.581011352 0 0 kegg stool_bileacids NA 0.827 no no no no no no Circadian entrainment CA+stool -0.512899897 0 0 kegg stool_bileacids NA 0.827 no up up no no no Clostridium CA+stool 0 0.692307692 0 Genus stool_bileacids 0.925 0.827 no no no no no no Cocaine addiction CA+stool 0 -0.763636364 0 kegg stool_bileacids NA 0.827 no no no no no no Coprococcus CA+stool 0 0 -0.596837945 butyrate-producing Genus stool_bileacids 0.612 0.827 no no no no no no Coronavirus disease - COVID-19 CA+stool -0.632610939 0 0 kegg stool_bileacids NA 0.827 no no no no no no Cortisol synthesis and secretion CA+stool 0 -0.836363636 0 kegg stool_bileacids NA 0.827 no no up no no no Cushing syndrome CA+stool -0.647058824 -0.609090909 0 kegg stool_bileacids NA 0.827 no no up no no no Diabetic cardiomyopathy CA+stool 0 0 0.544889893 kegg stool_bileacids NA 0.827 no no no no no no Dorea CA+stool 0 0.713286713 0 Genus stool_bileacids 0.00362 0.827 up no dn no no no Endocrine resistance CA+stool -0.595459236 -0.718181818 0 kegg stool_bileacids NA 0.827 no no no no no no Endocytosis CA+stool 0.680082559 0.609090909 0.57312253 kegg stool_bileacids NA 0.827 no no no no no no Epithelial cell signaling in Helicobacter pylori infection CA+stool 0.872033024 0 0 kegg stool_bileacids NA 0.827 no no no no no no Epstein-Barr virus infection CA+stool 0.510835913 0 0.492941841 kegg stool_bileacids NA 0.827 no no no no no no Fc gamma R-mediated phagocytosis CA+stool 0.620227038 0 0 kegg stool_bileacids NA 0.827 no no no no no no Ferroptosis CA+stool 0 -0.7 0 kegg stool_bileacids NA 0.827 no no no no no no Focal adhesion CA+stool 0 0.654545455 0 kegg stool_bileacids NA 0.827 no up up no no no FoxO signaling pathway CA+stool 0 0 -0.540372671 kegg stool_bileacids NA 0.827 no no no no no no GABAergic synapse CA+stool 0.543859649 0 0 kegg stool_bileacids NA 0.827 no up up no no no Gap junction CA+stool 0 -0.809090909 0 kegg stool_bileacids NA 0.827 no no no no no no Glucagon signaling pathway CA+stool -0.607843137 0 0 kegg stool_bileacids NA 0.827 no no no no no no Glutamatergic synapse CA+stool 0 -0.863636364 0 kegg stool_bileacids NA 0.827 no up up no no no Glycolysis / Gluconeogenesis CA+stool 0 0.781818182 0 kegg stool_bileacids NA 0.827 no no no no no no GnRH signaling pathway CA+stool 0 -0.672727273 0 kegg stool_bileacids NA 0.827 no no no no no no Graft-versus-host disease CA+stool 0 0.690909091 0.5256917 kegg stool_bileacids NA 0.827 no no no no no no "Growth hormone synthesis, secretion and action" CA+stool 0 -0.818181818 0 kegg stool_bileacids NA 0.827 no no no no no no Hematopoietic cell lineage CA+stool 0 0.690909091 0 kegg stool_bileacids NA 0.827 no no no no no no Hepatitis B CA+stool 0.475748194 0 0 kegg stool_bileacids NA 0.827 no no no no no no Herpes simplex virus 1 infection CA+stool 0 0 0.560700169 kegg stool_bileacids NA 0.827 no no no no no no Human cytomegalovirus infection CA+stool 0 0 0.5256917 kegg stool_bileacids NA 0.827 no no dn no no no Human immunodeficiency virus 1 infection CA+stool 0 0 0.548277809 kegg stool_bileacids NA 0.827 no no no no no no Human papillomavirus infection CA+stool 0.614035088 0 0.485036702 kegg stool_bileacids NA 0.827 no no no no no no Human T-cell leukemia virus 1 infection CA+stool 0 0 0.513269339 kegg stool_bileacids NA 0.827 no no no no no no Huntington disease CA+stool 0 0 0.555053642 kegg stool_bileacids NA 0.827 no no no no no no IL-17 signaling pathway CA+stool 0.671826625 0 0 kegg stool_bileacids NA 0.827 no no no no no no Inflammatory mediator regulation of TRP channels CA+stool -0.490196078 0 0 kegg stool_bileacids NA 0.827 no no no no no no Insulin secretion CA+stool 0 -0.745454545 0 yes kegg stool_bileacids NA 0.827 no up up no no no Leukocyte transendothelial migration CA+stool 0 0.609090909 0 kegg stool_bileacids NA 0.827 no no no no no no Lipid and atherosclerosis CA+stool 0.706914345 0 0 kegg stool_bileacids NA 0.827 no no no no no no Long-term depression CA+stool 0 -0.636363636 0 kegg stool_bileacids NA 0.827 no no no no no no Longevity regulating pathway CA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.827 no no no no no no Longevity regulating pathway - multiple species CA+stool 0 0.645454545 0 kegg stool_bileacids NA 0.827 no no no no no no Lysosome CA+stool 0.657378741 0 0 kegg stool_bileacids NA 0.827 no no no no no no Melanogenesis CA+stool -0.618163055 0 0 kegg stool_bileacids NA 0.827 no no no no no no Morphine addiction CA+stool 0 -0.609090909 0 kegg stool_bileacids NA 0.827 no up up no no no Natural killer cell mediated cytotoxicity CA+stool 0.620227038 0.645454545 0.474872953 kegg stool_bileacids NA 0.827 no no no no no no Neutrophil extracellular trap formation CA+stool 0.719298246 0 0 kegg stool_bileacids NA 0.827 no no no no no no NF-kappa B signaling pathway CA+stool 0.531475748 0 0 kegg stool_bileacids NA 0.827 no no no no no no NOD-like receptor signaling pathway CA+stool 0.609907121 0 0 kegg stool_bileacids NA 0.827 no no no no no no Non-alcoholic fatty liver disease CA+stool 0 0 0.517786561 kegg stool_bileacids NA 0.827 no no no no no no Odoribacter CA+stool 0 0.608391608 0 butyrate-producing Genus stool_bileacids 0.798 0.827 no no no no no no Oocyte meiosis CA+stool 0 0.609090909 0 kegg stool_bileacids NA 0.827 no no no no no no Osteoclast differentiation CA+stool 0.756449948 0 0 kegg stool_bileacids NA 0.827 no no no no no no Oxidative phosphorylation CA+stool 0 0 0.567476002 kegg stool_bileacids NA 0.827 no no no no no no p53 signaling pathway CA+stool 0 -0.645454545 0 kegg stool_bileacids NA 0.827 no no no no no no Parkinson disease CA+stool -0.469556244 0 0 kegg stool_bileacids NA 0.827 no no no no no no Pathogenic Escherichia coli infection CA+stool 0.605779154 0.618181818 0 kegg stool_bileacids NA 0.827 no no no no no no Pathways in cancer CA+stool 0 -0.645454545 0 kegg stool_bileacids NA 0.827 no no no no no no Peroxisome CA+stool 0.535603715 0 0 kegg stool_bileacids NA 0.827 no no no no no no Pertussis CA+stool 0.708978328 0 0 kegg stool_bileacids NA 0.827 no no dn no no no Phagosome CA+stool 0.560371517 0 0 kegg stool_bileacids NA 0.827 no no no no no no Phospholipase D signaling pathway CA+stool 0 -0.672727273 0 kegg stool_bileacids NA 0.827 no up up no no no Prion disease CA+stool 0 0 0.551665726 kegg stool_bileacids NA 0.827 no no no no no no Proteasome CA+stool 0 0.836363636 0 kegg stool_bileacids NA 0.827 no no no no no no Protein processing in endoplasmic reticulum CA+stool -0.492260062 0 0 kegg stool_bileacids NA 0.827 no no no no no no Regulation of actin cytoskeleton CA+stool 0 0.681818182 0.462450593 kegg stool_bileacids NA 0.827 no no no no no no Regulation of lipolysis in adipocytes CA+stool 0 -0.736363636 0 kegg stool_bileacids NA 0.827 no no no no no no Renin secretion CA+stool -0.595459236 0 0 kegg stool_bileacids NA 0.827 no no no no no no Retrograde endocannabinoid signaling CA+stool 0 0 0.642010164 kegg stool_bileacids NA 0.827 no no up no no no Ribosome CA+stool -0.64499484 0 0 kegg stool_bileacids NA 0.827 no no no no no no Ribosome biogenesis in eukaryotes CA+stool -0.498452012 0 0 kegg stool_bileacids NA 0.827 no no no no no no RIG-I-like receptor signaling pathway CA+stool 0.587203302 0 0 kegg stool_bileacids NA 0.827 no no no no no no Roseburia CA+stool 0 0 0.443675889 butyrate-producing Genus stool_bileacids 0.495 0.827 no no no no no no Salmonella infection CA+stool 0.494324045 0.745454545 0 kegg stool_bileacids NA 0.827 no no no no no no Serotonergic synapse CA+stool 0 -0.909090909 0 kegg stool_bileacids NA 0.827 no no no no no no Systemic lupus erythematosus CA+stool 0.475748194 0 0 kegg stool_bileacids NA 0.827 no no no no no no Thermogenesis CA+stool -0.498452012 0 0.482778091 kegg stool_bileacids NA 0.827 no no no no no no Thyroid hormone synthesis CA+stool -0.620227038 -0.672727273 0 kegg stool_bileacids NA 0.827 no no no no no no Toll-like receptor signaling pathway CA+stool 0.523219814 0 0 yes kegg stool_bileacids NA 0.827 no no no no no no Transcriptional misregulation in cancer CA+stool 0.486068111 0 0 kegg stool_bileacids NA 0.827 no no no no no no Tuberculosis CA+stool 0.512899897 0 0 kegg stool_bileacids NA 0.827 no no dn no no no Type I diabetes mellitus CA+stool 0 0.690909091 0.556182947 kegg stool_bileacids NA 0.827 no no no no no no Ubiquitin mediated proteolysis CA+stool -0.484004128 0 0 kegg stool_bileacids NA 0.827 no no no no no no Viral carcinogenesis CA+stool 0.651186791 0 0.527950311 kegg stool_bileacids NA 0.827 no no no no no no Viral myocarditis CA+stool 0 0.690909091 0.579898363 kegg stool_bileacids NA 0.827 no no no no no no Yersinia infection CA+stool 0.547987616 0 0 kegg stool_bileacids NA 0.827 no no no no no no 2-Oxocarboxylic acid metabolism Calcium signaling pathway -0.562608696 0 0 kegg kegg NA NA no no no no up up ABC transporters Calcium signaling pathway -0.673913043 0 0 kegg kegg NA NA no up up no up up "Alanine, aspartate and glutamate metabolism" Calcium signaling pathway -0.434782609 -0.589920949 -0.581209781 kegg kegg NA NA no no no no up up alpha-Linolenic acid metabolism Calcium signaling pathway -0.88 -0.710474308 -0.570656371 kegg kegg NA NA no no no no up up Amino sugar and nucleotide sugar metabolism Calcium signaling pathway -0.836521739 -0.48715415 -0.588674389 kegg kegg NA NA no no no no up up Aminoacyl-tRNA biosynthesis Calcium signaling pathway -0.633043478 0 0 kegg kegg NA NA no no no no up up Arginine and proline metabolism Calcium signaling pathway -0.617391304 -0.549407115 0 kegg kegg NA NA no up no no up up Arginine biosynthesis Calcium signaling pathway -0.486956522 -0.532608696 -0.558815959 kegg kegg NA NA no no no no up up beta-Alanine metabolism Calcium signaling pathway -0.78173913 -0.41798419 -0.642985843 kegg kegg NA NA no no no no up up Biosynthesis of amino acids Calcium signaling pathway -0.732173913 -0.592885375 -0.666666667 kegg kegg NA NA no no no no up up Biosynthesis of unsaturated fatty acids Calcium signaling pathway -0.513913043 -0.5 -0.403603604 kegg kegg NA NA no no no no up up Blautia Calcium signaling pathway 0 -0.494071146 0 acetate-producing Genus kegg 1.36E-05 NA up dn dn no up up Butanoate metabolism Calcium signaling pathway -0.643478261 0 0 kegg kegg NA NA no no no no up up Butyricimonas Calcium signaling pathway 0.458112494 0 0 butyrate-producing Genus kegg 0.17 NA no no no no up up Carbon metabolism Calcium signaling pathway -0.731304348 0 -0.704761905 kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) Calcium signaling pathway -0.452173913 0 0 kegg kegg NA NA no no no no up up Drug metabolism - other enzymes Calcium signaling pathway -0.68 0 -0.481595882 kegg kegg NA NA no no no no up up EGFR tyrosine kinase inhibitor resistance Calcium signaling pathway 0 0.458498024 0 kegg kegg NA NA no no no no up up Endocrine resistance Calcium signaling pathway 0.644347826 0.516798419 0.543114543 kegg kegg NA NA no no no no up up ErbB signaling pathway Calcium signaling pathway 0.460869565 0 0 kegg kegg NA NA no no no no up up Ether lipid metabolism Calcium signaling pathway 0.537391304 0 0 kegg kegg NA NA no no no no up up Fatty acid biosynthesis Calcium signaling pathway 0 -0.591897233 -0.410810811 kegg kegg NA NA no no no no up up Fatty acid degradation Calcium signaling pathway -0.692173913 -0.798418972 -0.748777349 kegg kegg NA NA no no no no up up Fatty acid elongation Calcium signaling pathway -0.589565217 0 -0.425997426 kegg kegg NA NA no no no no up up Fatty acid metabolism Calcium signaling pathway -0.747826087 -0.851778656 -0.711969112 kegg kegg NA NA no no no no up up Fructose and mannose metabolism Calcium signaling pathway -0.863478261 0 -0.615958816 kegg kegg NA NA no no no no up up Galactose metabolism Calcium signaling pathway -0.852173913 -0.565217391 -0.45019305 kegg kegg NA NA no no no no up up Glutathione metabolism Calcium signaling pathway 0 0.507905138 0 kegg kegg NA NA no no no no up up Glycolysis / Gluconeogenesis Calcium signaling pathway -0.719130435 0 -0.542857143 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate Calcium signaling pathway 0.746956522 0.631422925 0.452509653 kegg kegg NA NA no no no no up up Glycosaminoglycan degradation Calcium signaling pathway 0 -0.467391304 0 kegg kegg NA NA no no up no up up Glycosphingolipid biosynthesis - lacto and neolacto series Calcium signaling pathway 0.525217391 0 0.456370656 kegg kegg NA NA no no no no up up Glyoxylate and dicarboxylate metabolism Calcium signaling pathway -0.595652174 -0.556324111 -0.585585586 kegg kegg NA NA no no no no up up Histidine metabolism Calcium signaling pathway -0.714782609 -0.640316206 -0.685971686 kegg kegg NA NA no no no no up up Mannose type O-glycan biosynthesis Calcium signaling pathway 0.57826087 0 0.40952381 kegg kegg NA NA no no no no up up MAPK signaling pathway Calcium signaling pathway 0 -0.62944664 0 kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 Calcium signaling pathway -0.443478261 0 -0.402831403 kegg kegg NA NA no no no no up up Mismatch repair Calcium signaling pathway -0.424347826 0 0 kegg kegg NA NA no no no no up up mRNA surveillance pathway Calcium signaling pathway 0.654782609 0.583003953 0.621879022 kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis Calcium signaling pathway 0 -0.437747036 0 kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Calcium signaling pathway -0.453913043 -0.505928854 -0.422136422 kegg kegg NA NA no no no no up up Non-homologous end-joining Calcium signaling pathway -0.637391304 0 0 kegg kegg NA NA no no no no up up Oscillospira Calcium signaling pathway 0 -0.476284585 0 LPS-producing Genus kegg 0.62 NA no no no no up up Other glycan degradation Calcium signaling pathway -0.649565217 0 0 kegg kegg NA NA no no no no up up Oxidative phosphorylation Calcium signaling pathway 0.679130435 0.736166008 0 kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis Calcium signaling pathway 0 -0.710474308 -0.632432432 kegg kegg NA NA no no dn no up up Pentose phosphate pathway Calcium signaling pathway -0.516521739 -0.46541502 -0.645559846 kegg kegg NA NA no no no no up up Phenylalanine metabolism Calcium signaling pathway -0.436521739 0 0 kegg kegg NA NA no no no no up up PPAR signaling pathway Calcium signaling pathway 0 -0.4743083 0 kegg kegg NA NA no no no no up up Prevotella Calcium signaling pathway 0 0 0.487431749 acetate-producing Genus kegg 0.287 NA no no no no up up Primary bile acid biosynthesis Calcium signaling pathway -0.516521739 0 -0.530501931 kegg kegg NA NA no no no no up up Propanoate metabolism Calcium signaling pathway -0.507826087 0 0 kegg kegg NA NA no no no no up up Protein export Calcium signaling pathway 0.490434783 0 0.411583012 kegg kegg NA NA no no no no up up Pyrimidine metabolism Calcium signaling pathway -0.772173913 0 0 kegg kegg NA NA no no no no up up Pyruvate metabolism Calcium signaling pathway -0.459130435 0 0 kegg kegg NA NA no no no no up up Rap1 signaling pathway Calcium signaling pathway 0 0.479249012 0 kegg kegg NA NA no no no no up up Ras signaling pathway Calcium signaling pathway 0.552173913 0.418972332 0 yes kegg kegg NA NA no up up no up up Retinol metabolism Calcium signaling pathway -0.646086957 0 0 kegg kegg NA NA no no no no up up Ribosome Calcium signaling pathway 0.591304348 0.616600791 0 kegg kegg NA NA no no no no up up RNA degradation Calcium signaling pathway 0.700869565 0.530632411 0.477220077 kegg kegg NA NA no no no no up up Spliceosome Calcium signaling pathway 0 0 0.401801802 kegg kegg NA NA no no no no up up Starch and sucrose metabolism Calcium signaling pathway -0.795652174 -0.675889328 -0.645302445 kegg kegg NA NA no no no no up up Steroid hormone biosynthesis Calcium signaling pathway -0.547826087 0 0 kegg kegg NA NA no no no no up up Sulfur metabolism Calcium signaling pathway 0 0 -0.404375804 kegg kegg NA NA no no no no up up Thiamine metabolism Calcium signaling pathway -0.579130435 0 0 kegg kegg NA NA no no no no up up Tryptophan metabolism Calcium signaling pathway -0.668695652 0 -0.433719434 kegg kegg NA NA no up no no up up Tyrosine metabolism Calcium signaling pathway -0.48 0 -0.514285714 kegg kegg NA NA no no no no up up Ubiquinone and other terpenoid-quinone biosynthesis Calcium signaling pathway -0.607826087 0 0 kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" Calcium signaling pathway -0.580869565 0 0 kegg kegg NA NA no no no no up up 2-Oxocarboxylic acid metabolism cAMP signaling pathway -0.794782609 -0.557312253 -0.652767053 yes kegg kegg NA NA no no no no up up ABC transporters cAMP signaling pathway -0.544347826 0 0 yes kegg kegg NA NA no up up no up up alpha-Linolenic acid metabolism cAMP signaling pathway -0.700869565 0 -0.717631918 yes kegg kegg NA NA no no no no up up Amino sugar and nucleotide sugar metabolism cAMP signaling pathway -0.677391304 -0.505928854 -0.662290862 yes kegg kegg NA NA no no no no up up Aminoacyl-tRNA biosynthesis cAMP signaling pathway -0.719130435 -0.661067194 0 yes kegg kegg NA NA no no no no up up Antifolate resistance cAMP signaling pathway 0 -0.499011858 0 yes kegg kegg NA NA no no no no up up Arachidonic acid metabolism cAMP signaling pathway -0.422608696 0 0 yes kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism cAMP signaling pathway 0 0 -0.566023166 yes kegg kegg NA NA no no no no up up Bacteroides cAMP signaling pathway -0.415652174 -0.520750988 0 LPS-producing yes Genus kegg 0.000267 NA dn dn up no up up Basal transcription factors cAMP signaling pathway 0 -0.518774704 0 yes kegg kegg NA NA no no no no up up Base excision repair cAMP signaling pathway 0 -0.615612648 -0.449163449 yes kegg kegg NA NA no no no no up up beta-Alanine metabolism cAMP signaling pathway -0.922608696 -0.693675889 -0.798455598 yes kegg kegg NA NA no no no no up up Biosynthesis of amino acids cAMP signaling pathway -0.750434783 0 0 yes kegg kegg NA NA no no no no up up Biosynthesis of cofactors cAMP signaling pathway -0.470434783 -0.464426877 0 yes kegg kegg NA NA no no no no up up Biosynthesis of unsaturated fatty acids cAMP signaling pathway -0.626956522 -0.690711462 -0.636808237 yes kegg kegg NA NA no no no no up up Butanoate metabolism cAMP signaling pathway -0.862608696 -0.747035573 -0.637580438 yes kegg kegg NA NA no no no no up up Butyricimonas cAMP signaling pathway 0.521205831 0 0 butyrate-producing yes Genus kegg 0.17 NA no no no no up up Calcium signaling pathway cAMP signaling pathway 0.735652174 0 0.66023166 yes kegg kegg NA NA no up up no up up Carbon metabolism cAMP signaling pathway -0.812173913 0 -0.493178893 yes kegg kegg NA NA no no no no up up cGMP-PKG signaling pathway cAMP signaling pathway 0.464347826 0 0 yes kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) cAMP signaling pathway -0.635652174 -0.769762846 -0.626512227 yes kegg kegg NA NA no no no no up up Clostridium cAMP signaling pathway 0 -0.416691439 0 yes Genus kegg 0.925 NA no no no no up up Cysteine and methionine metabolism cAMP signaling pathway 0 -0.750988142 0 yes kegg kegg NA NA no no no no up up DNA replication cAMP signaling pathway 0 -0.781620553 -0.442985843 yes kegg kegg NA NA no no no no up up Drug metabolism - cytochrome P450 cAMP signaling pathway 0 -0.714426877 -0.601544402 yes kegg kegg NA NA no no no no up up Drug metabolism - other enzymes cAMP signaling pathway -0.760869565 -0.550395257 -0.433204633 yes kegg kegg NA NA no no no no up up Endocrine resistance cAMP signaling pathway 0.49826087 0 0.608236808 yes kegg kegg NA NA no no no no up up ErbB signaling pathway cAMP signaling pathway 0.405217391 0 0 yes kegg kegg NA NA no no no no up up Ether lipid metabolism cAMP signaling pathway 0.535652174 0 -0.404118404 yes kegg kegg NA NA no no no no up up Fanconi anemia pathway cAMP signaling pathway 0 -0.623517787 -0.404890605 yes kegg kegg NA NA no no no no up up Fatty acid degradation cAMP signaling pathway -0.656521739 0 -0.59047619 yes kegg kegg NA NA no no no no up up Fatty acid elongation cAMP signaling pathway -0.72173913 -0.648221344 -0.643500644 yes kegg kegg NA NA no no no no up up Fatty acid metabolism cAMP signaling pathway -0.746086957 0 -0.547747748 yes kegg kegg NA NA no no no no up up Fructose and mannose metabolism cAMP signaling pathway -0.791304348 0 0 yes kegg kegg NA NA no no no no up up Galactose metabolism cAMP signaling pathway -0.792173913 0 -0.497554698 yes kegg kegg NA NA no no no no up up Glycolysis / Gluconeogenesis cAMP signaling pathway -0.796521739 -0.589920949 -0.594337194 yes kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate cAMP signaling pathway 0 0.480237154 0 yes kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin cAMP signaling pathway -0.530434783 0 0 yes kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate cAMP signaling pathway 0.431304348 0 0 yes kegg kegg NA NA no no no no up up Glycosphingolipid biosynthesis - ganglio series cAMP signaling pathway 0 -0.604743083 0 yes kegg kegg NA NA no no no no up up Glycosphingolipid biosynthesis - lacto and neolacto series cAMP signaling pathway 0.444347826 0.451581028 0 yes kegg kegg NA NA no no no no up up Glyoxylate and dicarboxylate metabolism cAMP signaling pathway -0.520869565 0 0 yes kegg kegg NA NA no no no no up up Histidine metabolism cAMP signaling pathway -0.608695652 -0.43972332 -0.684684685 yes kegg kegg NA NA no no no no up up Homologous recombination cAMP signaling pathway 0 -0.41798419 0 yes kegg kegg NA NA no no no no up up Mannose type O-glycan biosynthesis cAMP signaling pathway 0.415652174 0 0 yes kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 cAMP signaling pathway -0.42173913 -0.709486166 -0.608494208 yes kegg kegg NA NA no no no no up up Mismatch repair cAMP signaling pathway -0.509565217 -0.868577075 -0.496782497 yes kegg kegg NA NA no no no no up up mRNA surveillance pathway cAMP signaling pathway 0.706956522 0 0 yes kegg kegg NA NA no no no no up up N-Glycan biosynthesis cAMP signaling pathway 0 -0.491106719 0 yes kegg kegg NA NA no no no no up up Non-homologous end-joining cAMP signaling pathway -0.813913043 -0.821146245 -0.595109395 yes kegg kegg NA NA no no no no up up Nucleotide excision repair cAMP signaling pathway 0 -0.791501976 -0.467696268 yes kegg kegg NA NA no no no no up up One carbon pool by folate cAMP signaling pathway 0 -0.748023715 -0.411840412 yes kegg kegg NA NA no no no no up up Other glycan degradation cAMP signaling pathway 0 0 -0.427541828 yes kegg kegg NA NA no no no no up up Oxidative phosphorylation cAMP signaling pathway 0.746956522 0 0 yes kegg kegg NA NA no no no no up up Pentose and glucuronate interconversions cAMP signaling pathway 0 -0.605731225 -0.479021879 yes kegg kegg NA NA no no no no up up Phenylalanine metabolism cAMP signaling pathway -0.640869565 -0.677865613 -0.462548263 yes kegg kegg NA NA no no no no up up PPAR signaling pathway cAMP signaling pathway 0 0.415019763 0 yes kegg kegg NA NA no no no no up up Prevotella cAMP signaling pathway 0 0 0.517684184 acetate-producing yes Genus kegg 0.287 NA no no no no up up Primary bile acid biosynthesis cAMP signaling pathway -0.632173913 -0.696640316 -0.505534106 yes kegg kegg NA NA no no no no up up Propanoate metabolism cAMP signaling pathway -0.470434783 -0.748023715 0 yes kegg kegg NA NA no no no no up up Proteasome cAMP signaling pathway 0 -0.580039526 -0.423166023 yes kegg kegg NA NA no no no no up up Protein export cAMP signaling pathway 0.413913043 0 0 yes kegg kegg NA NA no no no no up up Pyrimidine metabolism cAMP signaling pathway -0.811304348 -0.654150198 0 yes kegg kegg NA NA no no no no up up Pyruvate metabolism cAMP signaling pathway -0.516521739 -0.698616601 -0.421364221 yes kegg kegg NA NA no no no no up up Retinol metabolism cAMP signaling pathway -0.597391304 -0.774703557 -0.667438867 yes kegg kegg NA NA no no no no up up Ribosome cAMP signaling pathway 0.553043478 0 0 yes kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes cAMP signaling pathway 0 -0.626482213 0 yes kegg kegg NA NA no no no no up up RNA degradation cAMP signaling pathway 0.627826087 0 0 yes kegg kegg NA NA no no no no up up RNA polymerase cAMP signaling pathway 0 -0.518774704 0 yes kegg kegg NA NA no no no no up up Selenocompound metabolism cAMP signaling pathway 0 -0.447628458 -0.472329472 yes kegg kegg NA NA no no no no up up Starch and sucrose metabolism cAMP signaling pathway -0.420869565 0 0 yes kegg kegg NA NA no no no no up up Steroid biosynthesis cAMP signaling pathway 0 -0.820158103 -0.579150579 yes kegg kegg NA NA no no no no up up Steroid hormone biosynthesis cAMP signaling pathway -0.48 -0.743083004 -0.457400257 yes kegg kegg NA NA no no no no up up Sulfur metabolism cAMP signaling pathway -0.491304348 0 0 yes kegg kegg NA NA no no no no up up Synthesis and degradation of ketone bodies cAMP signaling pathway -0.443478261 -0.813241107 -0.495495495 yes kegg kegg NA NA no no no no up up Terpenoid backbone biosynthesis cAMP signaling pathway 0 -0.646245059 0 yes kegg kegg NA NA no no no no up up Thiamine metabolism cAMP signaling pathway 0 -0.467391304 0 yes kegg kegg NA NA no no no no up up Tryptophan metabolism cAMP signaling pathway -0.852173913 -0.817193676 -0.641956242 yes kegg kegg NA NA no up no no up up Tyrosine metabolism cAMP signaling pathway -0.634782609 -0.790513834 -0.701930502 yes kegg kegg NA NA no no no no up up Ubiquinone and other terpenoid-quinone biosynthesis cAMP signaling pathway -0.677391304 -0.818181818 -0.453024453 yes kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" cAMP signaling pathway -0.740869565 -0.756916996 -0.723037323 yes kegg kegg NA NA no no no no up up Various types of N-glycan biosynthesis cAMP signaling pathway 0 -0.486166008 0 yes kegg kegg NA NA no no no no up up 16:0-LPC+blood capric acid C6+blood 0 0 -0.401709402 serum_phospholipids serum_scfa 0.00456 0.433 up up no no no no 16:0-LPE+blood capric acid C6+blood 0 0 -0.48034188 serum_phospholipids serum_scfa 0.0711 0.433 up up no no no no 16:0/16:0-PI+blood capric acid C6+blood 0 0 -0.576752137 serum_phospholipids serum_scfa 0.358 0.433 no no no no no no 16:0/16:1-PI+blood capric acid C6+blood 0 0 -0.645128205 serum_phospholipids serum_scfa 0.262 0.433 no no no no no no 16:0/18:2-PI+blood capric acid C6+blood 0 0 -0.659487179 serum_phospholipids serum_scfa 0.269 0.433 no no no no no no 16:0/20:4-PI+blood capric acid C6+blood 0 0 -0.579487179 serum_phospholipids serum_scfa 0.558 0.433 no no no no no no 16:1/18:1-PG+blood capric acid C6+blood 0 0.490196078 0 serum_phospholipids serum_scfa 3.21E-05 0.433 no up up no no no 18:0-LPA+blood capric acid C6+blood 0 0.779411765 0 serum_phospholipids serum_scfa 0.0725 0.433 no dn no no no no 18:0-LPE+blood capric acid C6+blood 0 0 -0.422905983 serum_phospholipids serum_scfa 0.491 0.433 no no no no no no 18:0/18:2-PI+blood capric acid C6+blood 0 0 -0.541880342 serum_phospholipids serum_scfa 0.179 0.433 no no no no no no 18:1-LPC+blood capric acid C6+blood 0.506766917 0 0 serum_phospholipids serum_scfa 0.179 0.433 no no no no no no 18:1-LPE+blood capric acid C6+blood 0 0 -0.407863248 serum_phospholipids serum_scfa 0.117 0.433 no no no no no no 18:1/16:0-PI+blood capric acid C6+blood 0 0.49754902 -0.447521368 serum_phospholipids serum_scfa 0.793 0.433 no no no no no no 18:1/18:0-PI+blood capric acid C6+blood 0 0 -0.553504274 serum_phospholipids serum_scfa 0.0931 0.433 no no up no no no 18:1/22:6-PE+blood capric acid C6+blood 0 0 0.411282051 serum_phospholipids serum_scfa 0.0047 0.433 no up no no no no 18:2-LPE+blood capric acid C6+blood 0 0 -0.526837607 serum_phospholipids serum_scfa 0.112 0.433 no no no no no no 18:3/16:0-PE+blood capric acid C6+blood 0 0 -0.514529915 serum_phospholipids serum_scfa 0.00149 0.433 up up no no no no 18:3n6+blood capric acid C6+blood 0 0 -0.531623932 serum_fattyacid serum_scfa 0.0463 0.433 up no dn no no no 20:0+blood capric acid C6+blood 0.615037594 0 -0.632820513 yes serum_fattyacid serum_scfa 0.000278 0.433 dn no up no no no 20:1-LPA+blood capric acid C6+blood 0 0.735294118 0 serum_phospholipids serum_scfa 0.0187 0.433 dn dn no no no no 20:1-LPC+blood capric acid C6+blood 0.634586466 0 0 serum_phospholipids serum_scfa 0.217 0.433 no no no no no no 20:1-LPE+blood capric acid C6+blood 0.666165414 0 0 serum_phospholipids serum_scfa 0.465 0.433 no no no no no no 20:2-LPE+blood capric acid C6+blood 0.642105263 0 0 serum_phospholipids serum_scfa 0.177 0.433 no no no no no no 20:4-LPA+blood capric acid C6+blood 0 0.495098039 0 serum_phospholipids serum_scfa 0.398 0.433 no no no no no no 22:1-LPA+blood capric acid C6+blood 0 0.551470588 0 serum_phospholipids serum_scfa 0.00373 0.433 no up up no no no 22:2-LPA+blood capric acid C6+blood 0 0.612745098 0 serum_phospholipids serum_scfa 0.0443 0.433 dn no no no no no 24:1+blood capric acid C6+blood -0.511278195 0 0 serum_fattyacid serum_scfa 0.00582 0.433 no dn dn no no no acetic acid C2+blood capric acid C6+blood 0 0 0.453675214 serum_scfa serum_scfa 0.000193 0.433 up dn no no no no CA+blood capric acid C6+blood 0 0 -0.461409233 serum_bileacids serum_scfa 0.606 0.433 no no no no no no 2-Oxocarboxylic acid metabolism Carbohydrate digestion and absorption -0.426086957 0 0 kegg kegg NA NA no no no no no no ABC transporters Carbohydrate digestion and absorption 0 0.516798419 0 kegg kegg NA NA no up up no no no Adherens junction Carbohydrate digestion and absorption -0.583478261 -0.469367589 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Carbohydrate digestion and absorption 0.519130435 0.622529644 0.554954955 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Carbohydrate digestion and absorption 0.448695652 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Carbohydrate digestion and absorption 0.757391304 0.759881423 0.783526384 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Carbohydrate digestion and absorption 0 0 0.415701416 kegg kegg NA NA no no no no no no Antigen processing and presentation Carbohydrate digestion and absorption 0 -0.441699605 -0.440669241 kegg kegg NA NA no no no no no no Apelin signaling pathway Carbohydrate digestion and absorption 0 -0.539525692 0 kegg kegg NA NA no no no no no no Apoptosis Carbohydrate digestion and absorption 0 0.441699605 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Carbohydrate digestion and absorption 0 0 0.439382239 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Carbohydrate digestion and absorption -0.589565217 0 -0.43989704 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Carbohydrate digestion and absorption -0.522608696 -0.471343874 0.506306306 kegg kegg NA NA no no no no no no Autophagy - animal Carbohydrate digestion and absorption 0.790434783 0.654150198 0.775289575 kegg kegg NA NA no no no no no no Autophagy - other Carbohydrate digestion and absorption 0.579130435 0.416007905 0.526383526 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Carbohydrate digestion and absorption 0 0.536561265 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Carbohydrate digestion and absorption -0.476521739 -0.58201581 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Carbohydrate digestion and absorption -0.603478261 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Carbohydrate digestion and absorption -0.453043478 -0.56027668 0 kegg kegg NA NA no no no no no no Butanoate metabolism Carbohydrate digestion and absorption -0.470434783 -0.555335968 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Carbohydrate digestion and absorption 0.76173913 0.596837945 0 kegg kegg NA NA no no no no no no Cellular senescence Carbohydrate digestion and absorption 0 0.423913043 0 kegg kegg NA NA no no no no no no Cholinergic synapse Carbohydrate digestion and absorption 0.739130435 0 0.642728443 kegg kegg NA NA no no no no no no Circadian entrainment Carbohydrate digestion and absorption 0 -0.539525692 -0.536679537 kegg kegg NA NA no up up no no no Circadian rhythm Carbohydrate digestion and absorption 0.43826087 0 0.436550837 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Carbohydrate digestion and absorption -0.530434783 -0.657114625 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Carbohydrate digestion and absorption -0.410434783 0 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Carbohydrate digestion and absorption 0 -0.575098814 0 kegg kegg NA NA no no no no no no DNA replication Carbohydrate digestion and absorption 0 -0.421936759 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Carbohydrate digestion and absorption 0 -0.435770751 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Carbohydrate digestion and absorption -0.405217391 -0.614624506 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Carbohydrate digestion and absorption -0.512173913 -0.622529644 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Carbohydrate digestion and absorption 0.804347826 0.937747036 0.777091377 kegg kegg NA NA no no no no no no Estrogen signaling pathway Carbohydrate digestion and absorption 0 -0.520750988 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Carbohydrate digestion and absorption 0.450434783 0.443675889 0 kegg kegg NA NA no no no no no no Fatty acid elongation Carbohydrate digestion and absorption -0.569565217 -0.595849802 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Carbohydrate digestion and absorption 0.52 0.624505929 0.561904762 kegg kegg NA NA no no no no no no Ferroptosis Carbohydrate digestion and absorption 0 0 -0.526640927 kegg kegg NA NA no no no no no no Focal adhesion Carbohydrate digestion and absorption -0.472173913 -0.527667984 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Carbohydrate digestion and absorption 0.584347826 0.611660079 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Carbohydrate digestion and absorption 0 0.539525692 0 kegg kegg NA NA no no no no no no Galactose metabolism Carbohydrate digestion and absorption 0 0.529644269 0.565250965 kegg kegg NA NA no no no no no no Gap junction Carbohydrate digestion and absorption 0 0 -0.48030888 kegg kegg NA NA no no no no no no Gastric acid secretion Carbohydrate digestion and absorption -0.595652174 -0.523715415 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Carbohydrate digestion and absorption 0 0 -0.451480051 kegg kegg NA NA no up up no no no Glutathione metabolism Carbohydrate digestion and absorption -0.475652174 -0.4743083 -0.534105534 kegg kegg NA NA no no no no no no Glycerolipid metabolism Carbohydrate digestion and absorption 0 0.587944664 0.600772201 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Carbohydrate digestion and absorption 0 0 0.622651223 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Carbohydrate digestion and absorption -0.486956522 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Carbohydrate digestion and absorption 0 -0.640316206 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Carbohydrate digestion and absorption 0.447826087 0.777667984 0.553925354 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Carbohydrate digestion and absorption -0.512173913 0 0.445302445 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Carbohydrate digestion and absorption 0 0 0.550836551 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Carbohydrate digestion and absorption -0.448695652 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Carbohydrate digestion and absorption -0.432173913 0 0 kegg kegg NA NA no no no no no no GnRH secretion Carbohydrate digestion and absorption 0.784347826 0.93972332 0.82960103 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Carbohydrate digestion and absorption 0.615652174 0.65513834 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Carbohydrate digestion and absorption 0 0 0.606949807 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Carbohydrate digestion and absorption 0 -0.462450593 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Carbohydrate digestion and absorption -0.62173913 -0.432806324 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Carbohydrate digestion and absorption 0 0 0.65997426 kegg kegg NA NA no no no no no no Histidine metabolism Carbohydrate digestion and absorption -0.408695652 0 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Carbohydrate digestion and absorption 0.42173913 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Carbohydrate digestion and absorption 0 0.470355731 0.688803089 kegg kegg NA NA no no no no no no Insulin resistance Carbohydrate digestion and absorption 0.689565217 0.752964427 0.462805663 kegg kegg NA NA no no no no no no Insulin signaling pathway Carbohydrate digestion and absorption 0 -0.480237154 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Carbohydrate digestion and absorption 0 0.682806324 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Carbohydrate digestion and absorption -0.474782609 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Carbohydrate digestion and absorption 0 -0.490118577 0 kegg kegg NA NA no no up no no no Lysine degradation Carbohydrate digestion and absorption 0 0 0.627284427 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Carbohydrate digestion and absorption 0 0.43972332 0.512741313 kegg kegg NA NA no no no no no no MAPK signaling pathway Carbohydrate digestion and absorption 0 0 0.635006435 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Carbohydrate digestion and absorption 0 0 0.476705277 kegg kegg NA NA no up no no no no Metabolism of xenobiotics by cytochrome P450 Carbohydrate digestion and absorption -0.455652174 -0.664031621 0 kegg kegg NA NA no no no no no no Mismatch repair Carbohydrate digestion and absorption -0.448695652 -0.498023715 0 kegg kegg NA NA no no no no no no Mitophagy - animal Carbohydrate digestion and absorption 0 0 -0.552638353 kegg kegg NA NA no no no no no no Necroptosis Carbohydrate digestion and absorption 0 0 -0.541827542 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Carbohydrate digestion and absorption 0.622608696 0.576086957 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Carbohydrate digestion and absorption 0.570434783 0.650197628 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Carbohydrate digestion and absorption 0 0.441699605 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Carbohydrate digestion and absorption 0 0.483201581 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Carbohydrate digestion and absorption 0 -0.433794466 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Carbohydrate digestion and absorption -0.411304348 -0.545454545 0 kegg kegg NA NA no no no no no no Notch signaling pathway Carbohydrate digestion and absorption 0 0.628458498 0.614157014 kegg kegg NA NA no no no no no no Nucleotide excision repair Carbohydrate digestion and absorption 0 -0.415019763 0 kegg kegg NA NA no no no no no no Oocyte meiosis Carbohydrate digestion and absorption 0 -0.580039526 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Carbohydrate digestion and absorption 0 0.448616601 0 kegg kegg NA NA no no no no no no Other glycan degradation Carbohydrate digestion and absorption 0 0.416996047 0.706306306 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Carbohydrate digestion and absorption 0 0 0.607207207 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Carbohydrate digestion and absorption 0 0 -0.465894466 kegg kegg NA NA no up up no no no Oxidative phosphorylation Carbohydrate digestion and absorption 0 -0.469367589 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Carbohydrate digestion and absorption -0.5 -0.446640316 0 kegg kegg NA NA no no no no no no p53 signaling pathway Carbohydrate digestion and absorption 0.467826087 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Carbohydrate digestion and absorption -0.702608696 -0.561264822 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Carbohydrate digestion and absorption -0.668695652 -0.554347826 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Carbohydrate digestion and absorption 0 0 0.609266409 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Carbohydrate digestion and absorption 0 0.606719368 0 kegg kegg NA NA no up up no no no Phototransduction Carbohydrate digestion and absorption 0 -0.767786561 0 kegg kegg NA NA no no no no no no Platelet activation Carbohydrate digestion and absorption -0.559130435 -0.451581028 0 kegg kegg NA NA no no no no no no Platinum drug resistance Carbohydrate digestion and absorption 0.47826087 0.455533597 0.524324324 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Carbohydrate digestion and absorption 0 0 -0.435006435 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Carbohydrate digestion and absorption -0.526086957 -0.644268775 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Carbohydrate digestion and absorption 0.649565217 0.446640316 0.665122265 kegg kegg NA NA no no no no no no Prolactin signaling pathway Carbohydrate digestion and absorption 0.749565217 0.709486166 0.524839125 kegg kegg NA NA no no no no no no Propanoate metabolism Carbohydrate digestion and absorption 0 -0.591897233 0 kegg kegg NA NA no no no no no no Proteasome Carbohydrate digestion and absorption 0 -0.661067194 0 kegg kegg NA NA no no no no no no Protein export Carbohydrate digestion and absorption 0 -0.559288538 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Carbohydrate digestion and absorption 0 -0.419960474 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Carbohydrate digestion and absorption 0 -0.441699605 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Carbohydrate digestion and absorption 0 -0.616600791 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Carbohydrate digestion and absorption -0.565217391 -0.62055336 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Carbohydrate digestion and absorption 0.50173913 0.463438735 0 kegg kegg NA NA no no no no no no Renin secretion Carbohydrate digestion and absorption -0.463478261 -0.558300395 -0.501673102 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Carbohydrate digestion and absorption 0 -0.542490119 0 kegg kegg NA NA no no up no no no Ribosome Carbohydrate digestion and absorption 0 -0.4743083 -0.447619048 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Carbohydrate digestion and absorption 0.759130435 0.605731225 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Carbohydrate digestion and absorption 0 0 0.544658945 kegg kegg NA NA no no no no no no Serotonergic synapse Carbohydrate digestion and absorption 0 0 -0.422651223 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Carbohydrate digestion and absorption 0.59826087 0.70256917 0.638095238 kegg kegg NA NA no no no no no no Sphingolipid metabolism Carbohydrate digestion and absorption 0 0 0.526640927 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Carbohydrate digestion and absorption 0.613913043 0.462450593 0.578378378 kegg kegg NA NA no no no no no no Steroid biosynthesis Carbohydrate digestion and absorption 0 -0.577075099 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Carbohydrate digestion and absorption -0.643478261 -0.483201581 0 kegg kegg NA NA no no no no no no Sulfur metabolism Carbohydrate digestion and absorption -0.572173913 -0.41798419 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Carbohydrate digestion and absorption 0.550434783 0.480237154 0 kegg kegg NA NA no no no no no no Taste transduction Carbohydrate digestion and absorption 0 0 0.601544402 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Carbohydrate digestion and absorption 0.426086957 0.722332016 0.467438867 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Carbohydrate digestion and absorption 0 -0.490118577 0 kegg kegg NA NA no no no no no no Thermogenesis Carbohydrate digestion and absorption 0 -0.481225296 0 kegg kegg NA NA no no no no no no Thiamine metabolism Carbohydrate digestion and absorption 0 -0.550395257 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Carbohydrate digestion and absorption 0 0 -0.476705277 kegg kegg NA NA no no no no no no Tight junction Carbohydrate digestion and absorption -0.694782609 -0.591897233 -0.462548263 kegg kegg NA NA no no no no no no TNF signaling pathway Carbohydrate digestion and absorption 0.808695652 0.68972332 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Carbohydrate digestion and absorption 0.831304348 0.518774704 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Carbohydrate digestion and absorption -0.539130435 -0.621541502 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Carbohydrate digestion and absorption 0.895652174 0.908102767 0.840926641 kegg kegg NA NA no no no no no no Tyrosine metabolism Carbohydrate digestion and absorption -0.605217391 -0.554347826 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Carbohydrate digestion and absorption -0.576521739 -0.473320158 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Carbohydrate digestion and absorption 0 0 -0.56962677 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Carbohydrate digestion and absorption -0.48 -0.564229249 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Carbohydrate digestion and absorption 0 -0.587944664 -0.518918919 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Carbohydrate digestion and absorption 0 0 -0.508880309 kegg kegg NA NA no no no no no no VEGF signaling pathway Carbohydrate digestion and absorption 0.695652174 0.808300395 0.57966538 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Carbohydrate digestion and absorption 0 0 -0.628571429 kegg kegg NA NA no no no no no no Wnt signaling pathway Carbohydrate digestion and absorption 0 0 0.411068211 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Carbon metabolism 0 0 0.458687259 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Carbon metabolism 0.78 0 0.482110682 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Carbon metabolism 0.726956522 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Carbon metabolism 0.545217391 0 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Carbon metabolism 0 0 0.507850708 kegg kegg NA NA no no no no no no beta-Alanine metabolism Carbon metabolism 0.892173913 0.665019763 0.63037323 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Carbon metabolism 0.52173913 0.448616601 0 kegg kegg NA NA no no no no no no Butanoate metabolism Carbon metabolism 0.786086957 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Carbon metabolism 0.626956522 0 0 kegg kegg NA NA no no no no no no Clostridium Carbon metabolism 0 0.662223558 0 Genus kegg 0.925 NA no no no no no no Dorea Carbon metabolism 0 0.434890055 0 Genus kegg 0.00362 NA up no dn no no no Drug metabolism - cytochrome P450 Carbon metabolism 0 0 0.448906049 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Carbon metabolism 0.857391304 0.421936759 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Carbon metabolism -0.555652174 0 0 kegg kegg NA NA no no no no no no Fatty acid degradation Carbon metabolism 0.535652174 0 0.595881596 kegg kegg NA NA no no no no no no Fatty acid elongation Carbon metabolism 0.759130435 0.738142292 0.506048906 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Carbon metabolism 0.797391304 0 0.516344916 kegg kegg NA NA no no no no no no Galactose metabolism Carbon metabolism 0.750434783 0 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Carbon metabolism 0 -0.429841897 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Carbon metabolism 0 -0.630434783 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Carbon metabolism 0.9 0.703557312 0.774517375 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Carbon metabolism 0.680869565 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Carbon metabolism -0.495652174 0 -0.593822394 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Carbon metabolism -0.503478261 0 -0.438867439 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Carbon metabolism 0 -0.541501976 -0.453281853 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Carbon metabolism 0 0 0.590733591 kegg kegg NA NA no no no no no no Histidine metabolism Carbon metabolism 0.503478261 0 0.578120978 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Carbon metabolism 0 -0.427865613 0 kegg kegg NA NA no no no no no no Lachnospira Carbon metabolism 0 0.434890055 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Lysine degradation Carbon metabolism 0 -0.56027668 -0.474903475 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Carbon metabolism -0.575652174 -0.518774704 -0.544144144 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Carbon metabolism 0.513043478 0 0.520978121 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Carbon metabolism 0 0 0.557271557 kegg kegg NA NA no no no no no no Odoribacter Carbon metabolism 0 0.634474457 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Other types of O-glycan biosynthesis Carbon metabolism -0.495652174 -0.711462451 -0.501158301 kegg kegg NA NA no no no no no no Oxidative phosphorylation Carbon metabolism -0.722608696 0 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Carbon metabolism 0 0 0.709395109 kegg kegg NA NA no no dn no no no Parabacteroides Carbon metabolism 0.468695652 0 0 Genus kegg 4.19E-05 NA no up up no no no Paraprevotella Carbon metabolism 0.458257827 0 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Carbon metabolism 0.453913043 0 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Carbon metabolism 0.605217391 0.574110672 0.796911197 kegg kegg NA NA no no no no no no Phenylalanine metabolism Carbon metabolism 0.664347826 0.462450593 0 kegg kegg NA NA no no no no no no Prevotella Carbon metabolism 0 0 -0.403035939 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Carbon metabolism 0.537391304 0.66798419 0.6 kegg kegg NA NA no no no no no no Propanoate metabolism Carbon metabolism 0.474782609 0 0 kegg kegg NA NA no no no no no no Pyramidobacter Carbon metabolism 0 0 -0.425454098 Genus kegg 0.45 NA no no no no no no Pyrimidine metabolism Carbon metabolism 0.688695652 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Carbon metabolism 0.419130435 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Carbon metabolism 0.65826087 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Carbon metabolism 0.51826087 0 0.512741313 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Carbon metabolism 0.53826087 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Carbon metabolism 0.512173913 0 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Carbon metabolism -0.45826087 -0.707509881 -0.456113256 kegg kegg NA NA no no no no no no Tryptophan metabolism Carbon metabolism 0.772173913 0.614624506 0.423166023 kegg kegg NA NA no up no no no no Tyrosine metabolism Carbon metabolism 0.615652174 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Carbon metabolism 0.508695652 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Carbon metabolism 0.620869565 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Cardiac muscle contraction -0.58 0 0 kegg kegg NA NA no no no no no up ABC transporters Cardiac muscle contraction -0.429565217 0 0 kegg kegg NA NA no up up no no up "Alanine, aspartate and glutamate metabolism" Cardiac muscle contraction -0.546086957 -0.790513834 -0.585585586 kegg kegg NA NA no no no no no up alpha-Linolenic acid metabolism Cardiac muscle contraction -0.629565217 -0.723320158 0 kegg kegg NA NA no no no no no up Amino sugar and nucleotide sugar metabolism Cardiac muscle contraction -0.597391304 0 0 kegg kegg NA NA no no no no no up Aminoacyl-tRNA biosynthesis Cardiac muscle contraction -0.607826087 0 0 kegg kegg NA NA no no no no no up Apoptosis Cardiac muscle contraction 0 -0.52173913 0 kegg kegg NA NA no no no no no up Apoptosis - multiple species Cardiac muscle contraction 0 -0.451581028 0 kegg kegg NA NA no no no no no up Arginine and proline metabolism Cardiac muscle contraction 0 -0.811264822 -0.596396396 kegg kegg NA NA no up no no no up Arginine biosynthesis Cardiac muscle contraction -0.553913043 -0.743083004 -0.537709138 kegg kegg NA NA no no no no no up Autophagy - animal Cardiac muscle contraction 0 -0.714426877 -0.444787645 kegg kegg NA NA no no no no no up beta-Alanine metabolism Cardiac muscle contraction -0.715652174 0 0 kegg kegg NA NA no no no no no up Biosynthesis of amino acids Cardiac muscle contraction -0.775652174 -0.653162055 -0.453796654 kegg kegg NA NA no no no no no up Biosynthesis of unsaturated fatty acids Cardiac muscle contraction -0.409565217 0 0 kegg kegg NA NA no no no no no up Butanoate metabolism Cardiac muscle contraction -0.624347826 0 0 kegg kegg NA NA no no no no no up Butyricimonas Cardiac muscle contraction 0 0 -0.422068072 butyrate-producing Genus kegg 0.17 NA no no no no no up Calcium signaling pathway Cardiac muscle contraction 0.731304348 0.770750988 0 kegg kegg NA NA no up up no no up cAMP signaling pathway Cardiac muscle contraction 0.770434783 0 0 yes kegg kegg NA NA no up up no no up Carbon metabolism Cardiac muscle contraction -0.749565217 0 0 kegg kegg NA NA no no no no no up cGMP-PKG signaling pathway Cardiac muscle contraction 0 -0.64229249 0 kegg kegg NA NA no no no no no up Chemokine signaling pathway Cardiac muscle contraction 0 -0.414031621 0 kegg kegg NA NA no no no no no up Cysteine and methionine metabolism Cardiac muscle contraction 0 0.451581028 0 kegg kegg NA NA no no no no no up Cytokine-cytokine receptor interaction Cardiac muscle contraction 0 -0.446640316 0 kegg kegg NA NA no no no no no up DNA replication Cardiac muscle contraction 0 0.45256917 0 kegg kegg NA NA no no no no no up Drug metabolism - cytochrome P450 Cardiac muscle contraction 0 0.485177866 0 kegg kegg NA NA no no no no no up Drug metabolism - other enzymes Cardiac muscle contraction -0.583478261 0.527667984 0 kegg kegg NA NA no no no no no up EGFR tyrosine kinase inhibitor resistance Cardiac muscle contraction 0 0.670948617 0 kegg kegg NA NA no no no no no up Endocytosis Cardiac muscle contraction -0.413913043 0 0 kegg kegg NA NA no no no no no up Ether lipid metabolism Cardiac muscle contraction 0.632173913 0 0 kegg kegg NA NA no no no no no up Fatty acid biosynthesis Cardiac muscle contraction -0.427826087 -0.792490119 -0.594594595 kegg kegg NA NA no no no no no up Fatty acid degradation Cardiac muscle contraction -0.659130435 -0.858695652 0 kegg kegg NA NA no no no no no up Fatty acid elongation Cardiac muscle contraction -0.507826087 0 0 kegg kegg NA NA no no no no no up Fatty acid metabolism Cardiac muscle contraction -0.745217391 -0.851778656 0 kegg kegg NA NA no no no no no up Folate biosynthesis Cardiac muscle contraction 0 0.459486166 0 kegg kegg NA NA no no no no no up FoxO signaling pathway Cardiac muscle contraction 0 -0.713438735 0 kegg kegg NA NA no no no no no up Fructose and mannose metabolism Cardiac muscle contraction -0.759130435 -0.537549407 -0.54954955 kegg kegg NA NA no no no no no up Galactose metabolism Cardiac muscle contraction -0.727826087 -0.677865613 0 kegg kegg NA NA no no no no no up Glutathione metabolism Cardiac muscle contraction 0 0.603754941 0 kegg kegg NA NA no no no no no up Glycerolipid metabolism Cardiac muscle contraction 0 -0.533596838 0 kegg kegg NA NA no no up no no up Glycolysis / Gluconeogenesis Cardiac muscle contraction -0.62173913 0.428853755 0 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Cardiac muscle contraction 0 -0.692687747 0 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - keratan sulfate Cardiac muscle contraction 0.506956522 0.458498024 0 kegg kegg NA NA no no no no no up Glycosaminoglycan degradation Cardiac muscle contraction 0 -0.435770751 0 kegg kegg NA NA no no up no no up Glyoxylate and dicarboxylate metabolism Cardiac muscle contraction -0.694782609 -0.75 -0.596396396 kegg kegg NA NA no no no no no up HIF-1 signaling pathway Cardiac muscle contraction 0 0.634387352 0 kegg kegg NA NA no no no no no up Inositol phosphate metabolism Cardiac muscle contraction 0 -0.416996047 0 kegg kegg NA NA no no no no no up Mannose type O-glycan biosynthesis Cardiac muscle contraction 0.442608696 0 0 kegg kegg NA NA no no no no no up MAPK signaling pathway Cardiac muscle contraction 0 -0.656126482 0 kegg kegg NA NA no no no no no up Metabolism of xenobiotics by cytochrome P450 Cardiac muscle contraction 0 0.440711462 0 kegg kegg NA NA no no no no no up Mitophagy - animal Cardiac muscle contraction 0.465217391 0.761857708 0 kegg kegg NA NA no no no no no up mRNA surveillance pathway Cardiac muscle contraction 0.662608696 0.635375494 0.413384813 kegg kegg NA NA no no no no no up mTOR signaling pathway Cardiac muscle contraction 0 0.641304348 0 kegg kegg NA NA no no no no no up Mucin type O-glycan biosynthesis Cardiac muscle contraction 0 -0.444664032 0 kegg kegg NA NA no no no no no up N-Glycan biosynthesis Cardiac muscle contraction 0 0.56916996 0 kegg kegg NA NA no no no no no up Neuroactive ligand-receptor interaction Cardiac muscle contraction 0 -0.533596838 0 kegg kegg NA NA up up up no no up NF-kappa B signaling pathway Cardiac muscle contraction 0 -0.699604743 0 kegg kegg NA NA no no no no no up Nicotinate and nicotinamide metabolism Cardiac muscle contraction -0.424347826 -0.726284585 -0.532303732 kegg kegg NA NA no no no no no up Nitrogen metabolism Cardiac muscle contraction -0.450434783 -0.66798419 -0.476962677 kegg kegg NA NA no no no no no up Non-homologous end-joining Cardiac muscle contraction -0.629565217 0 0 kegg kegg NA NA no no no no no up Oocyte meiosis Cardiac muscle contraction 0 0 0.40952381 kegg kegg NA NA no no no no no up Oscillospira Cardiac muscle contraction 0 -0.5 0 LPS-producing Genus kegg 0.62 NA no no no no no up Other glycan degradation Cardiac muscle contraction 0 -0.43972332 0 kegg kegg NA NA no no no no no up Oxidative phosphorylation Cardiac muscle contraction 0.97826087 0.979249012 0.972200772 kegg kegg NA NA no no no no no up Pantothenate and CoA biosynthesis Cardiac muscle contraction 0 -0.786561265 -0.555727156 kegg kegg NA NA no no dn no no up Pentose and glucuronate interconversions Cardiac muscle contraction 0 0.518774704 0 kegg kegg NA NA no no no no no up Pentose phosphate pathway Cardiac muscle contraction -0.471304348 -0.543478261 -0.533075933 kegg kegg NA NA no no no no no up Peroxisome Cardiac muscle contraction -0.591304348 -0.765810277 -0.485714286 kegg kegg NA NA no no no no no up Phagosome Cardiac muscle contraction -0.513913043 0 0 kegg kegg NA NA no no no no no up Phosphatidylinositol signaling system Cardiac muscle contraction 0.542608696 0 0 kegg kegg NA NA no no no no no up Phospholipase D signaling pathway Cardiac muscle contraction 0 -0.499011858 0 kegg kegg NA NA no up up no no up PPAR signaling pathway Cardiac muscle contraction 0 -0.600790514 0 kegg kegg NA NA no no no no no up Propanoate metabolism Cardiac muscle contraction 0 0.418972332 0 kegg kegg NA NA no no no no no up Proteasome Cardiac muscle contraction 0 0.446640316 0 kegg kegg NA NA no no no no no up Protein export Cardiac muscle contraction 0.449565217 0.721343874 0.472844273 kegg kegg NA NA no no no no no up Protein processing in endoplasmic reticulum Cardiac muscle contraction 0 0.581027668 0 kegg kegg NA NA no no no no no up Pyrimidine metabolism Cardiac muscle contraction -0.737391304 0 0 kegg kegg NA NA no no no no no up Pyruvate metabolism Cardiac muscle contraction 0 0.533596838 0 kegg kegg NA NA no no no no no up Rap1 signaling pathway Cardiac muscle contraction 0 0.472332016 0 kegg kegg NA NA no no no no no up Ras signaling pathway Cardiac muscle contraction 0 0.511857708 0.402831403 yes kegg kegg NA NA no up up no no up Retinol metabolism Cardiac muscle contraction -0.460869565 0 0 kegg kegg NA NA no no no no no up Ribosome Cardiac muscle contraction 0.636521739 0.843873518 0 kegg kegg NA NA no no no no no up RNA degradation Cardiac muscle contraction 0.609565217 0.684782609 0 kegg kegg NA NA no no no no no up RNA polymerase Cardiac muscle contraction 0 0.558300395 0 kegg kegg NA NA no no no no no up RNA transport Cardiac muscle contraction 0 0.545454545 0 kegg kegg NA NA no no no no no up SNARE interactions in vesicular transport Cardiac muscle contraction 0 -0.656126482 0 kegg kegg NA NA no no no no no up Sphingolipid signaling pathway Cardiac muscle contraction 0.453043478 0 0 kegg kegg NA NA no no no no no up Starch and sucrose metabolism Cardiac muscle contraction -0.459130435 -0.788537549 0 kegg kegg NA NA no no no no no up Sulfur metabolism Cardiac muscle contraction -0.453043478 0 0 kegg kegg NA NA no no no no no up Tryptophan metabolism Cardiac muscle contraction -0.57826087 0 0 kegg kegg NA NA no up no no no up Ubiquinone and other terpenoid-quinone biosynthesis Cardiac muscle contraction -0.408695652 0 0 kegg kegg NA NA no no no no no up Ubiquitin mediated proteolysis Cardiac muscle contraction 0.460869565 0.773715415 0 kegg kegg NA NA no no no no no up "Valine, leucine and isoleucine degradation" Cardiac muscle contraction -0.508695652 0 0 kegg kegg NA NA no no no no no up 12-ketoDCA+blood CDCA+blood 0.477529792 0 0 serum_bileacids serum_bileacids 0.517 0.506 no no no no no no 14:0-LPC+blood CDCA+blood 0.551879699 0 0 serum_phospholipids serum_bileacids 0.00689 0.506 up up no no no no 16:0/16:1-PI+blood CDCA+blood 0.515789474 0 0 serum_phospholipids serum_bileacids 0.262 0.506 no no no no no no 16:0/18:1-PC+blood CDCA+blood -0.476691729 0 0 serum_phospholipids serum_bileacids 6.15E-07 0.506 up up up no no no 16:0/20:5-PC+blood CDCA+blood 0 0 0.433846154 serum_phospholipids serum_bileacids 0.628 0.506 no no no no no no 16:0/20:5-PG+blood CDCA+blood -0.578947368 0 0 serum_phospholipids serum_bileacids 0.00656 0.506 no up no no no no 16:1-LPC+blood CDCA+blood 0 -0.509803922 0 serum_phospholipids serum_bileacids 0.0241 0.506 no up no no no no 16:1/16:0-PC+blood CDCA+blood -0.533834586 0 0 serum_phospholipids serum_bileacids 0.0215 0.506 no up up no no no 16:1/16:1-PC+blood CDCA+blood -0.685714286 0 0 serum_phospholipids serum_bileacids 0.0177 0.506 no no up no no no 16:1/18:1-PG+blood CDCA+blood -0.714285714 0 0 serum_phospholipids serum_bileacids 3.21E-05 0.506 no up up no no no 16:1/18:2-PG+blood CDCA+blood -0.673684211 0 0 serum_phospholipids serum_bileacids 1.40E-08 0.506 no up up no no no 18:0/16:0-PC+blood CDCA+blood -0.508270677 0 0 serum_phospholipids serum_bileacids 9.64E-07 0.506 up up up no no no 18:0/18:0-PS+blood CDCA+blood -0.470676692 0 0 serum_phospholipids serum_bileacids 0.00617 0.506 no up no no no no 18:0/18:2-PC+blood CDCA+blood -0.454135338 0 0 serum_phospholipids serum_bileacids 1.74E-06 0.506 no up up no no no 18:0/20:3-PI+blood CDCA+blood -0.666165414 0 0 serum_phospholipids serum_bileacids 0.377 0.506 no no no no no no 18:0/20:4-PI+blood CDCA+blood -0.721804511 0 0 serum_phospholipids serum_bileacids 0.167 0.506 no no no no no no 18:0/20:5-PC+blood CDCA+blood 0 0 -0.411965812 serum_phospholipids serum_bileacids 0.17 0.506 no no no no no no 18:0/22:6-PA+blood CDCA+blood -0.609022556 0 0 serum_phospholipids serum_bileacids 0.22 0.506 no no no no no no 18:1/18:0-PS+blood CDCA+blood -0.727819549 0 0 serum_phospholipids serum_bileacids 0.193 0.506 no no no no no no 18:1/18:1-PC+blood CDCA+blood 0 0 -0.406495726 serum_phospholipids serum_bileacids 1.34E-05 0.506 no up up no no no 18:1/18:1-PG+blood CDCA+blood -0.62556391 0 0 serum_phospholipids serum_bileacids 0.00352 0.506 no up up no no no 18:1/18:2-PG+blood CDCA+blood -0.658646617 0 0 serum_phospholipids serum_bileacids 5.58E-07 0.506 no up up no no no 18:1/20:3-PC+blood CDCA+blood 0 0 -0.496752137 serum_phospholipids serum_bileacids 0.00872 0.506 no up up no no no 18:1/20:4-PC+blood CDCA+blood 0 0 -0.401025641 serum_phospholipids serum_bileacids 0.582 0.506 no no no no no no 18:1+blood CDCA+blood 0 0 -0.522735043 yes serum_fattyacid serum_bileacids 0.00202 0.506 up no dn no no no 18:3-LPC+blood CDCA+blood 0.65112782 0 0.406495726 serum_phospholipids serum_bileacids 0.147 0.506 no no no no no no 18:3n3+blood CDCA+blood -0.469172932 0 0 serum_fattyacid serum_bileacids 0.291 0.506 no no no no no no 20:0/20:5-PC+blood CDCA+blood -0.754887218 0 -0.498119658 serum_phospholipids serum_bileacids 0.882 0.506 no no no no no no 20:1/20:4-PE+blood CDCA+blood -0.559398496 0 0 serum_phospholipids serum_bileacids 0.0042 0.506 up up no no no no 20:2/18:3-PE+blood CDCA+blood 0 0 -0.442051282 serum_phospholipids serum_bileacids 0.0391 0.506 up up no no no no 20:2+blood CDCA+blood 0 0 -0.550769231 serum_fattyacid serum_bileacids 0.478 0.506 no no no no no no 20:3/18:0-PC+blood CDCA+blood -0.484210526 0 0 serum_phospholipids serum_bileacids 0.296 0.506 no no no no no no 20:3/18:0-PI+blood CDCA+blood -0.655639098 0 0 serum_phospholipids serum_bileacids 0.289 0.506 no no no no no no 20:4-LPA+blood CDCA+blood 0 -0.536764706 -0.424957265 serum_phospholipids serum_bileacids 0.398 0.506 no no no no no no 20:4/18:0-PE+blood CDCA+blood -0.476691729 0 0 serum_phospholipids serum_bileacids 0.000755 0.506 up up no no no no 20:5-LPC+blood CDCA+blood 0 0 0.422905983 serum_phospholipids serum_bileacids 0.558 0.506 no no no no no no 20:5/18:0-PC+blood CDCA+blood -0.446616541 0 0 serum_phospholipids serum_bileacids 3.97E-06 0.506 no up up no no no 20:5n3+blood CDCA+blood 0 0 0.512478632 serum_fattyacid serum_bileacids 0.988 0.506 no no no no no no AA+blood CDCA+blood -0.461654135 0 0 serum_ARA serum_bileacids 0.212 0.506 no no no no no no Acute myeloid leukemia CDCA+blood 0 -0.688235294 0 kegg serum_bileacids NA 0.506 no no no no no no Adherens junction CDCA+blood 0 0.55 0 kegg serum_bileacids NA 0.506 no no no no no no Adrenergic signaling in cardiomyocytes CDCA+blood 0 0.635294118 0 kegg serum_bileacids NA 0.506 no no up no no no AGE-RAGE signaling pathway in diabetic complications CDCA+blood 0 -0.852941176 0 kegg serum_bileacids NA 0.506 no no no no no no Aldosterone synthesis and secretion CDCA+blood 0 0.617647059 0.462307692 kegg serum_bileacids NA 0.506 no up up no no no Alzheimer disease CDCA+blood 0 0.861764706 0 kegg serum_bileacids NA 0.506 no no no no no no Amoebiasis CDCA+blood 0 -0.711764706 0 kegg serum_bileacids NA 0.506 no no no no no no Amphetamine addiction CDCA+blood 0 0.761764706 0 kegg serum_bileacids NA 0.506 no no no no no no Amyotrophic lateral sclerosis CDCA+blood 0 0.911764706 0.416923077 kegg serum_bileacids NA 0.506 no no no no no no Apelin signaling pathway CDCA+blood 0 0.785294118 0 kegg serum_bileacids NA 0.506 no no no no no no Apoptosis CDCA+blood 0 -0.679411765 0 kegg serum_bileacids NA 0.506 no no no no no no Arginine and proline metabolism CDCA+blood 0 -0.832352941 0 kegg serum_bileacids NA 0.506 no up no no no no Arrhythmogenic right ventricular cardiomyopathy CDCA+blood 0 0.567647059 0 kegg serum_bileacids NA 0.506 no up up no no no Autophagy - animal CDCA+blood 0 -0.705882353 0 kegg serum_bileacids NA 0.506 no no no no no no B cell receptor signaling pathway CDCA+blood 0 -0.708823529 0 kegg serum_bileacids NA 0.506 no no no no no no Biosynthesis of amino acids CDCA+blood 0 -0.7 -0.401538462 kegg serum_bileacids NA 0.506 no no no no no no Biosynthesis of cofactors CDCA+blood 0.485964912 0.511764706 0 kegg serum_bileacids NA 0.506 no no no no no no Bladder cancer CDCA+blood 0 -0.867647059 0 kegg serum_bileacids NA 0.506 no no no no no no Breast cancer CDCA+blood 0 -0.661764706 0 kegg serum_bileacids NA 0.506 no no no no no no C-type lectin receptor signaling pathway CDCA+blood 0 -0.697058824 0 kegg serum_bileacids NA 0.506 no no no no no no CA+blood CDCA+blood 0.811583359 0.638871978 0.83053662 serum_bileacids serum_bileacids 0.606 0.506 no no no no no no CA+stool CDCA+blood 0 0 0.490225564 stool_bileacids serum_bileacids 0.827 0.506 no no no no no no capric acid C6+blood CDCA+blood 0 0 -0.427008547 serum_scfa serum_bileacids 0.433 0.506 no no no no no no Carbon metabolism CDCA+blood 0 0 -0.512307692 kegg serum_bileacids NA 0.506 no no no no no no Cardiac muscle contraction CDCA+blood 0 0.808823529 0.406923077 kegg serum_bileacids NA 0.506 no no up no no no Cell cycle CDCA+blood 0 0.702941176 0 kegg serum_bileacids NA 0.506 no no no no no no Cellular senescence CDCA+blood 0 -0.570588235 0 kegg serum_bileacids NA 0.506 no no no no no no cGMP-PKG signaling pathway CDCA+blood 0 -0.758823529 0 kegg serum_bileacids NA 0.506 no no no no no no Chagas disease CDCA+blood 0 -0.664705882 0 kegg serum_bileacids NA 0.506 no no no no no no Chemokine signaling pathway CDCA+blood 0 -0.658823529 0 kegg serum_bileacids NA 0.506 no no no no no no Choline metabolism in cancer CDCA+blood 0 -0.541176471 0 kegg serum_bileacids NA 0.506 no no no no no no Clostridium CDCA+blood 0 0 0.408967364 Genus serum_bileacids 0.925 0.506 no no no no no no Coprococcus CDCA+blood 0 0 -0.532307692 butyrate-producing Genus serum_bileacids 0.612 0.506 no no no no no no Coronavirus disease - COVID-19 CDCA+blood 0 0.802941176 0 kegg serum_bileacids NA 0.506 no no no no no no Cortisol synthesis and secretion CDCA+blood 0 0 0.466153846 kegg serum_bileacids NA 0.506 no no up no no no Cytosolic DNA-sensing pathway CDCA+blood 0.468421053 0 0 kegg serum_bileacids NA 0.506 no no no no no no Diabetic cardiomyopathy CDCA+blood 0 0.844117647 0 kegg serum_bileacids NA 0.506 no no no no no no Dilated cardiomyopathy CDCA+blood 0 0.570588235 0 kegg serum_bileacids NA 0.506 no up up no no no Dopaminergic synapse CDCA+blood 0 0.517647059 0.404615385 kegg serum_bileacids NA 0.506 no up no no no no EGFR tyrosine kinase inhibitor resistance CDCA+blood 0 0.752941176 0 kegg serum_bileacids NA 0.506 no no no no no no Endocytosis CDCA+blood 0 -0.514705882 0 kegg serum_bileacids NA 0.506 no no no no no no Epithelial cell signaling in Helicobacter pylori infection CDCA+blood 0 -0.782352941 0 kegg serum_bileacids NA 0.506 no no no no no no ErbB signaling pathway CDCA+blood 0 -0.5 0 kegg serum_bileacids NA 0.506 no no no no no no Estrogen signaling pathway CDCA+blood 0 0.644117647 0 kegg serum_bileacids NA 0.506 no no no no no no Fc epsilon RI signaling pathway CDCA+blood 0 -0.832352941 0 kegg serum_bileacids NA 0.506 no no no no no no Fc gamma R-mediated phagocytosis CDCA+blood -0.540350877 -0.697058824 -0.499230769 kegg serum_bileacids NA 0.506 no no no no no no Focal adhesion CDCA+blood 0 0.529411765 0 kegg serum_bileacids NA 0.506 no up up no no no FoxO signaling pathway CDCA+blood 0 -0.629411765 0 kegg serum_bileacids NA 0.506 no no no no no no GABAergic synapse CDCA+blood 0 -0.802941176 0 kegg serum_bileacids NA 0.506 no up up no no no Gastric acid secretion CDCA+blood 0 0.591176471 0 kegg serum_bileacids NA 0.506 no no no no no no Glucagon signaling pathway CDCA+blood 0 0.764705882 0 kegg serum_bileacids NA 0.506 no no no no no no Glutamatergic synapse CDCA+blood 0 -0.691176471 0 kegg serum_bileacids NA 0.506 no up up no no no "Glycine, serine and threonine metabolism" CDCA+blood 0.5 0 0 kegg serum_bileacids NA 0.506 no up no no no no Glycolysis / Gluconeogenesis CDCA+blood 0 0.623529412 0 kegg serum_bileacids NA 0.506 no no no no no no "Growth hormone synthesis, secretion and action" CDCA+blood 0 -0.517647059 0 kegg serum_bileacids NA 0.506 no no no no no no HCA+stool CDCA+blood 0 0 0.497744361 stool_bileacids serum_bileacids 0.155 0.506 no no no no no no Hepatitis B CDCA+blood 0 -0.785294118 0 kegg serum_bileacids NA 0.506 no no no no no no HIF-1 signaling pathway CDCA+blood 0 0.752941176 0 kegg serum_bileacids NA 0.506 no no no no no no Hippo signaling pathway CDCA+blood 0 0.688235294 0 kegg serum_bileacids NA 0.506 no no no no no no Human papillomavirus infection CDCA+blood 0 -0.529411765 0 kegg serum_bileacids NA 0.506 no no no no no no Huntington disease CDCA+blood 0 0.847058824 0 kegg serum_bileacids NA 0.506 no no no no no no IL-17 signaling pathway CDCA+blood 0 -0.732352941 0 kegg serum_bileacids NA 0.506 no no no no no no Inflammatory mediator regulation of TRP channels CDCA+blood 0 0.726470588 0 kegg serum_bileacids NA 0.506 no no no no no no Insulin resistance CDCA+blood 0 -0.585294118 0 kegg serum_bileacids NA 0.506 no no no no no no Insulin secretion CDCA+blood 0 0 0.430769231 yes kegg serum_bileacids NA 0.506 no up up no no no Insulin signaling pathway CDCA+blood 0 0.805882353 0 kegg serum_bileacids NA 0.506 no no no no no no iso-LCA+stool CDCA+blood 0 0 -0.458646617 stool_bileacids serum_bileacids 0.72 0.506 no no no no no no JAK-STAT signaling pathway CDCA+blood 0 -0.658823529 0 kegg serum_bileacids NA 0.506 no no no no no no Lipid and atherosclerosis CDCA+blood 0 -0.755882353 0 kegg serum_bileacids NA 0.506 no no no no no no Long-term potentiation CDCA+blood 0 0.755882353 0 kegg serum_bileacids NA 0.506 no no up no no no Lysosome CDCA+blood 0 -0.570588235 0 kegg serum_bileacids NA 0.506 no no no no no no Melanogenesis CDCA+blood 0 0.667647059 0 kegg serum_bileacids NA 0.506 no no no no no no MicroRNAs in cancer CDCA+blood 0 -0.564705882 0 kegg serum_bileacids NA 0.506 no no no no no no Mitophagy - animal CDCA+blood 0.529824561 0.611764706 0 kegg serum_bileacids NA 0.506 no no no no no no Morphine addiction CDCA+blood 0 0 0.481538462 kegg serum_bileacids NA 0.506 no up up no no no mRNA surveillance pathway CDCA+blood 0 0.738235294 0 kegg serum_bileacids NA 0.506 no no no no no no mTOR signaling pathway CDCA+blood 0 0.738235294 0 kegg serum_bileacids NA 0.506 no no no no no no Natural killer cell mediated cytotoxicity CDCA+blood 0 -0.511764706 0 kegg serum_bileacids NA 0.506 no no no no no no Neuroactive ligand-receptor interaction CDCA+blood 0 -0.520588235 0 kegg serum_bileacids NA 0.506 up up up no no no Neutrophil extracellular trap formation CDCA+blood 0 -0.667647059 0 kegg serum_bileacids NA 0.506 no no no no no no NF-kappa B signaling pathway CDCA+blood 0 -0.708823529 0 kegg serum_bileacids NA 0.506 no no no no no no Nicotinate and nicotinamide metabolism CDCA+blood 0 -0.9 0 kegg serum_bileacids NA 0.506 no no no no no no NOD-like receptor signaling pathway CDCA+blood 0 -0.779411765 0 kegg serum_bileacids NA 0.506 no no no no no no Non-alcoholic fatty liver disease CDCA+blood 0 0.738235294 0.486923077 kegg serum_bileacids NA 0.506 no no no no no no Non-small cell lung cancer CDCA+blood 0 -0.505882353 0 kegg serum_bileacids NA 0.506 no no no no no no Olfactory transduction CDCA+blood -0.515789474 -0.688235294 0 kegg serum_bileacids NA 0.506 no no no no no no Oocyte meiosis CDCA+blood 0 0.761764706 0 kegg serum_bileacids NA 0.506 no no no no no no Osteoclast differentiation CDCA+blood 0 -0.767647059 0 kegg serum_bileacids NA 0.506 no no no no no no Oxidative phosphorylation CDCA+blood 0 0.847058824 0 kegg serum_bileacids NA 0.506 no no no no no no Parkinson disease CDCA+blood 0 0.785294118 0 kegg serum_bileacids NA 0.506 no no no no no no Pathways of neurodegeneration - multiple diseases CDCA+blood 0 0.791176471 0 kegg serum_bileacids NA 0.506 no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer CDCA+blood 0 -0.576470588 0 kegg serum_bileacids NA 0.506 no no no no no no Peroxisome CDCA+blood 0 -0.735294118 0 kegg serum_bileacids NA 0.506 no no no no no no Pertussis CDCA+blood 0 -0.673529412 0 kegg serum_bileacids NA 0.506 no no dn no no no Phagosome CDCA+blood 0 -0.55 0 kegg serum_bileacids NA 0.506 no no no no no no Phospholipase D signaling pathway CDCA+blood 0 -0.811764706 0 kegg serum_bileacids NA 0.506 no up up no no no PPAR signaling pathway CDCA+blood 0 -0.738235294 0 kegg serum_bileacids NA 0.506 no no no no no no Prion disease CDCA+blood 0 0.9 0 kegg serum_bileacids NA 0.506 no no no no no no Prolactin signaling pathway CDCA+blood 0 -0.782352941 0 kegg serum_bileacids NA 0.506 no no no no no no Prostate cancer CDCA+blood 0 -0.511764706 0 kegg serum_bileacids NA 0.506 no no no no no no Proteasome CDCA+blood 0 0.691176471 0 kegg serum_bileacids NA 0.506 no no no no no no Protein processing in endoplasmic reticulum CDCA+blood 0 0.864705882 0 kegg serum_bileacids NA 0.506 no no no no no no Proteoglycans in cancer CDCA+blood 0.61754386 0.782352941 0 kegg serum_bileacids NA 0.506 no no no no no no Purine metabolism CDCA+blood 0 0.573529412 0 kegg serum_bileacids NA 0.506 no no no no no no Ras signaling pathway CDCA+blood 0 0.685294118 0 yes kegg serum_bileacids NA 0.506 no up up no no no Regulation of actin cytoskeleton CDCA+blood 0 0.594117647 0 kegg serum_bileacids NA 0.506 no no no no no no Relaxin signaling pathway CDCA+blood 0.484210526 -0.526470588 0 kegg serum_bileacids NA 0.506 no no no no no no Renin secretion CDCA+blood 0 0.723529412 0 kegg serum_bileacids NA 0.506 no no no no no no Retrograde endocannabinoid signaling CDCA+blood 0 0.826470588 0.403846154 kegg serum_bileacids NA 0.506 no no up no no no Rheumatoid arthritis CDCA+blood 0 -0.647058824 0 kegg serum_bileacids NA 0.506 no no no no no no Ribosome CDCA+blood 0 0.802941176 0 kegg serum_bileacids NA 0.506 no no no no no no Ribosome biogenesis in eukaryotes CDCA+blood 0 0.679411765 0 kegg serum_bileacids NA 0.506 no no no no no no RIG-I-like receptor signaling pathway CDCA+blood 0 -0.688235294 0 kegg serum_bileacids NA 0.506 no no no no no no RNA degradation CDCA+blood 0 0.797058824 0 kegg serum_bileacids NA 0.506 no no no no no no RNA transport CDCA+blood 0 0.714705882 0 kegg serum_bileacids NA 0.506 no no no no no no Serotonergic synapse CDCA+blood 0 -0.55 0 kegg serum_bileacids NA 0.506 no no no no no no Shigellosis CDCA+blood 0.489473684 0.5 0 kegg serum_bileacids NA 0.506 no no no no no no Small cell lung cancer CDCA+blood 0.470175439 0 0 kegg serum_bileacids NA 0.506 no no up no no no Spinocerebellar ataxia CDCA+blood 0 0.676470588 0 kegg serum_bileacids NA 0.506 no no no no no no Staphylococcus aureus infection CDCA+blood 0 -0.564705882 -0.494615385 kegg serum_bileacids NA 0.506 up no no no no no Systemic lupus erythematosus CDCA+blood -0.461403509 -0.655882353 -0.482307692 kegg serum_bileacids NA 0.506 no no no no no no Thermogenesis CDCA+blood 0 0.855882353 0 kegg serum_bileacids NA 0.506 no no no no no no Thyroid hormone signaling pathway CDCA+blood 0 0.511764706 0 kegg serum_bileacids NA 0.506 no no no no no no TNF signaling pathway CDCA+blood 0 -0.617647059 0 kegg serum_bileacids NA 0.506 no no no no no no Toll-like receptor signaling pathway CDCA+blood 0 -0.794117647 0 yes kegg serum_bileacids NA 0.506 no no no no no no Transcriptional misregulation in cancer CDCA+blood 0 -0.673529412 0 kegg serum_bileacids NA 0.506 no no no no no no Tuberculosis CDCA+blood -0.505263158 -0.629411765 -0.463846154 kegg serum_bileacids NA 0.506 no no dn no no no Ubiquitin mediated proteolysis CDCA+blood 0.526315789 0.755882353 0 kegg serum_bileacids NA 0.506 no no no no no no UDCA+stool CDCA+blood 0 0 0.467669173 stool_bileacids serum_bileacids 0.266 0.506 no no no no no no Vascular smooth muscle contraction CDCA+blood 0 0.655882353 0 kegg serum_bileacids NA 0.506 no no no no no no Viral carcinogenesis CDCA+blood 0 -0.594117647 0 kegg serum_bileacids NA 0.506 no no no no no no Wnt signaling pathway CDCA+blood 0 0.823529412 0 kegg serum_bileacids NA 0.506 no no no no no no Yersinia infection CDCA+blood 0 -0.614705882 0 kegg serum_bileacids NA 0.506 no no no no no no 12-ketoDCA+stool CDCA+stool -0.475748194 0 0 stool_bileacids stool_bileacids 0.505 0.663 no no no no no no 4-hydroxybenzoic acid+stool CDCA+stool 0 0 0.450592885 stool_cometabolism stool_bileacids 0.0536 0.663 no dn no no no no Adipocytokine signaling pathway CDCA+stool 0 0 -0.55053642 kegg stool_bileacids NA 0.663 no no no no no no Adrenergic signaling in cardiomyocytes CDCA+stool 0 -0.618181818 0.422924901 kegg stool_bileacids NA 0.663 no no up no no no Aldosterone synthesis and secretion CDCA+stool 0 0 0.426312818 kegg stool_bileacids NA 0.663 no up up no no no Allograft rejection CDCA+stool 0 0.790909091 0.569734613 kegg stool_bileacids NA 0.663 no no no no no no Alzheimer disease CDCA+stool -0.527347781 0 0.696216827 kegg stool_bileacids NA 0.663 no no no no no no Amphetamine addiction CDCA+stool -0.609907121 0 0 kegg stool_bileacids NA 0.663 no no no no no no AMPK signaling pathway CDCA+stool 0 -0.609090909 -0.553924337 kegg stool_bileacids NA 0.663 no no no no no no Amyotrophic lateral sclerosis CDCA+stool -0.578947368 0 0.700734049 kegg stool_bileacids NA 0.663 no no no no no no Apoptosis CDCA+stool 0.609907121 0 0 kegg stool_bileacids NA 0.663 no no no no no no Asthma CDCA+stool 0 0.609090909 0 kegg stool_bileacids NA 0.663 no no no no no no Autoimmune thyroid disease CDCA+stool 0 0.790909091 0.569734613 kegg stool_bileacids NA 0.663 no no no no no no Bacteroides CDCA+stool 0.599587203 0 0 LPS-producing Genus stool_bileacids 0.000267 0.663 dn dn up no no no Biosynthesis of amino acids CDCA+stool 0.647058824 0 0 kegg stool_bileacids NA 0.663 no no no no no no Blautia CDCA+stool 0 0.664335664 0 acetate-producing Genus stool_bileacids 1.36E-05 0.663 up dn dn no no no CA+stool CDCA+stool 0.867905057 0.874125874 0.914031621 stool_bileacids stool_bileacids 0.827 0.663 no no no no no no Carbon metabolism CDCA+stool 0 0.627272727 0 kegg stool_bileacids NA 0.663 no no no no no no Cardiac muscle contraction CDCA+stool -0.471620227 0 0.682665161 kegg stool_bileacids NA 0.663 no no up no no no Cell adhesion molecules CDCA+stool 0.477812178 0.7 0.491812535 kegg stool_bileacids NA 0.663 no no no no no no Cellular senescence CDCA+stool 0.628482972 0.681818182 0.560700169 kegg stool_bileacids NA 0.663 no no no no no no Chemical carcinogenesis - receptor activation CDCA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.663 no no no no no no Clostridium CDCA+stool 0 0.58041958 0 Genus stool_bileacids 0.925 0.663 no no no no no no Cocaine addiction CDCA+stool 0 -0.609090909 0 kegg stool_bileacids NA 0.663 no no no no no no Coprococcus CDCA+stool 0 0 -0.462450593 butyrate-producing Genus stool_bileacids 0.612 0.663 no no no no no no Coronavirus disease - COVID-19 CDCA+stool -0.541795666 0 0 kegg stool_bileacids NA 0.663 no no no no no no Cortisol synthesis and secretion CDCA+stool 0 -0.718181818 0 kegg stool_bileacids NA 0.663 no no up no no no Cushing syndrome CDCA+stool -0.504643963 0 0 kegg stool_bileacids NA 0.663 no no up no no no Diabetic cardiomyopathy CDCA+stool -0.488132095 0 0.656691135 kegg stool_bileacids NA 0.663 no no no no no no Dorea CDCA+stool 0.500515996 0.685314685 0 Genus stool_bileacids 0.00362 0.663 up no dn no no no Endocrine resistance CDCA+stool -0.543859649 -0.672727273 0 kegg stool_bileacids NA 0.663 no no no no no no Endocytosis CDCA+stool 0.636738906 0.618181818 0.535855449 kegg stool_bileacids NA 0.663 no no no no no no Epithelial cell signaling in Helicobacter pylori infection CDCA+stool 0.713106295 0 0 kegg stool_bileacids NA 0.663 no no no no no no Epstein-Barr virus infection CDCA+stool 0 0 0.424054207 kegg stool_bileacids NA 0.663 no no no no no no Fc gamma R-mediated phagocytosis CDCA+stool 0.533539732 0 0 kegg stool_bileacids NA 0.663 no no no no no no FoxO signaling pathway CDCA+stool 0 0 -0.516657256 kegg stool_bileacids NA 0.663 no no no no no no GABAergic synapse CDCA+stool 0.543859649 0 0 kegg stool_bileacids NA 0.663 no up up no no no Glutamatergic synapse CDCA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.663 no up up no no no GnRH signaling pathway CDCA+stool 0 -0.618181818 0 kegg stool_bileacids NA 0.663 no no no no no no Graft-versus-host disease CDCA+stool 0 0.790909091 0.55053642 kegg stool_bileacids NA 0.663 no no no no no no "Growth hormone synthesis, secretion and action" CDCA+stool 0 -0.672727273 0 kegg stool_bileacids NA 0.663 no no no no no no Herpes simplex virus 1 infection CDCA+stool 0 0.654545455 0.514398645 kegg stool_bileacids NA 0.663 no no no no no no Hippo signaling pathway CDCA+stool 0 0.618181818 0 kegg stool_bileacids NA 0.663 no no no no no no Human cytomegalovirus infection CDCA+stool 0 0 0.446640316 kegg stool_bileacids NA 0.663 no no dn no no no Human immunodeficiency virus 1 infection CDCA+stool 0 0 0.444381705 kegg stool_bileacids NA 0.663 no no no no no no Human papillomavirus infection CDCA+stool 0.620227038 0.618181818 0 kegg stool_bileacids NA 0.663 no no no no no no Human T-cell leukemia virus 1 infection CDCA+stool 0 0 0.488424619 kegg stool_bileacids NA 0.663 no no no no no no Huntington disease CDCA+stool -0.583075335 0 0.658949746 kegg stool_bileacids NA 0.663 no no no no no no IL-17 signaling pathway CDCA+stool 0.510835913 0 0 kegg stool_bileacids NA 0.663 no no no no no no Insulin secretion CDCA+stool 0 -0.654545455 0 yes kegg stool_bileacids NA 0.663 no up up no no no JAK-STAT signaling pathway CDCA+stool 0 0 -0.501976285 kegg stool_bileacids NA 0.663 no no no no no no Lipid and atherosclerosis CDCA+stool 0.576883385 0 0 kegg stool_bileacids NA 0.663 no no no no no no Long-term potentiation CDCA+stool 0 0 0.495200452 kegg stool_bileacids NA 0.663 no no up no no no Longevity regulating pathway CDCA+stool 0 -0.7 -0.541501976 kegg stool_bileacids NA 0.663 no no no no no no Lysosome CDCA+stool 0.498452012 0 0 kegg stool_bileacids NA 0.663 no no no no no no Melanogenesis CDCA+stool -0.494324045 0 0 kegg stool_bileacids NA 0.663 no no no no no no Mitophagy - animal CDCA+stool 0 0 -0.434217956 kegg stool_bileacids NA 0.663 no no no no no no mRNA surveillance pathway CDCA+stool -0.492260062 0 0 kegg stool_bileacids NA 0.663 no no no no no no Natural killer cell mediated cytotoxicity CDCA+stool 0.576883385 0.681818182 0 kegg stool_bileacids NA 0.663 no no no no no no Neutrophil extracellular trap formation CDCA+stool 0.620227038 0 0 kegg stool_bileacids NA 0.663 no no no no no no NOD-like receptor signaling pathway CDCA+stool 0.500515996 0 0 kegg stool_bileacids NA 0.663 no no no no no no Non-alcoholic fatty liver disease CDCA+stool -0.475748194 0 0.567476002 kegg stool_bileacids NA 0.663 no no no no no no Oscillospira CDCA+stool 0 0 -0.477272727 LPS-producing Genus stool_bileacids 0.62 0.663 no no no no no no Osteoclast differentiation CDCA+stool 0.568627451 0 0 kegg stool_bileacids NA 0.663 no no no no no no Oxidative phosphorylation CDCA+stool -0.525283798 0 0.661208357 kegg stool_bileacids NA 0.663 no no no no no no Parkinson disease CDCA+stool -0.488132095 0 0 kegg stool_bileacids NA 0.663 no no no no no no Pathogenic Escherichia coli infection CDCA+stool 0.492260062 0 0 kegg stool_bileacids NA 0.663 no no no no no no Pathways in cancer CDCA+stool 0 0 -0.542631282 kegg stool_bileacids NA 0.663 no no no no no no Pathways of neurodegeneration - multiple diseases CDCA+stool -0.488132095 0 0 kegg stool_bileacids NA 0.663 no no no no no no Peroxisome CDCA+stool 0.506707946 0 0 kegg stool_bileacids NA 0.663 no no no no no no Pertussis CDCA+stool 0.694530444 0 0 kegg stool_bileacids NA 0.663 no no dn no no no Phagosome CDCA+stool 0.523219814 0 0 kegg stool_bileacids NA 0.663 no no no no no no Porphyrin and chlorophyll metabolism CDCA+stool 0 0 -0.4432524 kegg stool_bileacids NA 0.663 no no no no no no Prion disease CDCA+stool -0.498452012 0 0.682665161 kegg stool_bileacids NA 0.663 no no no no no no Proteasome CDCA+stool 0 0.790909091 0 kegg stool_bileacids NA 0.663 no no no no no no Purine metabolism CDCA+stool 0 0 -0.508752117 kegg stool_bileacids NA 0.663 no no no no no no Regulation of actin cytoskeleton CDCA+stool 0 0 0.518915867 kegg stool_bileacids NA 0.663 no no no no no no Regulation of lipolysis in adipocytes CDCA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.663 no no no no no no Retrograde endocannabinoid signaling CDCA+stool 0 0 0.743647657 kegg stool_bileacids NA 0.663 no no up no no no Ribosome CDCA+stool -0.564499484 0 0 kegg stool_bileacids NA 0.663 no no no no no no Roseburia CDCA+stool 0 0 0.420948617 butyrate-producing Genus stool_bileacids 0.495 0.663 no no no no no no Salmonella infection CDCA+stool 0.50877193 0.627272727 0 kegg stool_bileacids NA 0.663 no no no no no no Serotonergic synapse CDCA+stool 0 -0.8 0 kegg stool_bileacids NA 0.663 no no no no no no Thermogenesis CDCA+stool -0.614035088 0 0.608130999 kegg stool_bileacids NA 0.663 no no no no no no Type I diabetes mellitus CDCA+stool 0 0.790909091 0.571993224 kegg stool_bileacids NA 0.663 no no no no no no Viral carcinogenesis CDCA+stool 0.570691434 0 0.4432524 kegg stool_bileacids NA 0.663 no no no no no no Viral myocarditis CDCA+stool 0 0.818181818 0.599096556 kegg stool_bileacids NA 0.663 no no no no no no ¦Ø-MCA+stool CDCA+stool 0 0.592647768 0 stool_bileacids stool_bileacids 0.919 0.663 no no no no no no 2-Oxocarboxylic acid metabolism Cell adhesion molecules 0.489565217 0 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Cell adhesion molecules 0 -0.550395257 0 kegg kegg NA NA no no up no no no alpha-Linolenic acid metabolism Cell adhesion molecules 0.427826087 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Cell adhesion molecules 0 0 -0.425225225 kegg kegg NA NA no no no no no no AMPK signaling pathway Cell adhesion molecules 0 -0.685770751 0 kegg kegg NA NA no no no no no no Antifolate resistance Cell adhesion molecules 0 0 -0.60978121 kegg kegg NA NA no no no no no no Apelin signaling pathway Cell adhesion molecules -0.465217391 0 0 kegg kegg NA NA no no no no no no Apoptosis Cell adhesion molecules 0.492173913 0.692687747 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Cell adhesion molecules 0 0 -0.557528958 kegg kegg NA NA no no no no no no Autophagy - other Cell adhesion molecules -0.564347826 0 0 kegg kegg NA NA no no no no no no Bacteroides Cell adhesion molecules 0.432173913 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Cell adhesion molecules -0.617391304 -0.602766798 -0.625997426 kegg kegg NA NA no no no no no no Base excision repair Cell adhesion molecules 0 -0.471343874 -0.491891892 kegg kegg NA NA no no no no no no beta-Alanine metabolism Cell adhesion molecules 0.449565217 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Cell adhesion molecules 0.705217391 0.695652174 0.486743887 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Cell adhesion molecules 0 -0.809288538 0 kegg kegg NA NA no no no no no no Butyricicoccus Cell adhesion molecules 0 0 0.509406759 butyrate-producing Genus kegg 0.852 NA no no no no no no cAMP signaling pathway Cell adhesion molecules -0.500869565 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Cell adhesion molecules 0.611304348 0.576086957 0.415958816 kegg kegg NA NA no no no no no no Cardiac muscle contraction Cell adhesion molecules -0.487826087 0 0 kegg kegg NA NA no no up no no no Cell cycle Cell adhesion molecules -0.548695652 -0.615612648 -0.400772201 kegg kegg NA NA no no no no no no Cellular senescence Cell adhesion molecules 0.859130435 0.913043478 0.824195624 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Cell adhesion molecules 0 0.58201581 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Cell adhesion molecules 0 0.472332016 0.490862291 kegg kegg NA NA no no no no no no DNA replication Cell adhesion molecules 0 0 -0.445817246 kegg kegg NA NA no no no no no no Endocrine resistance Cell adhesion molecules 0 -0.662055336 0 kegg kegg NA NA no no no no no no Endocytosis Cell adhesion molecules 0.894782609 0.967391304 0.881595882 kegg kegg NA NA no no no no no no Ether lipid metabolism Cell adhesion molecules -0.615652174 -0.751976285 -0.501930502 kegg kegg NA NA no no no no no no Fanconi anemia pathway Cell adhesion molecules 0 -0.500988142 -0.524839125 kegg kegg NA NA no no no no no no Focal adhesion Cell adhesion molecules 0.446956522 0 0 kegg kegg NA NA no up up no no no Folate biosynthesis Cell adhesion molecules -0.424347826 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Cell adhesion molecules 0 0 -0.428828829 kegg kegg NA NA no no no no no no Galactose metabolism Cell adhesion molecules 0 0.423913043 0 kegg kegg NA NA no no no no no no Glutathione metabolism Cell adhesion molecules 0 -0.585968379 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Cell adhesion molecules -0.551304348 -0.435770751 -0.477220077 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Cell adhesion molecules 0 -0.750988142 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Cell adhesion molecules 0.470434783 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Cell adhesion molecules 0.47826087 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Cell adhesion molecules 0 0.609683794 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Cell adhesion molecules 0 -0.714426877 -0.417503218 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Cell adhesion molecules -0.446956522 -0.42687747 0 kegg kegg NA NA no no no no no no Homologous recombination Cell adhesion molecules 0 -0.43083004 -0.580694981 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Cell adhesion molecules 0 0 -0.461261261 kegg kegg NA NA no no no no no no Longevity regulating pathway Cell adhesion molecules 0 -0.507905138 0 kegg kegg NA NA no no no no no no Lysine degradation Cell adhesion molecules 0 0 -0.423680824 kegg kegg NA NA no no no no no no Lysosome Cell adhesion molecules 0 0.733201581 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Cell adhesion molecules -0.45826087 0 0 kegg kegg NA NA no no no no no no Mismatch repair Cell adhesion molecules 0 -0.469367589 0 kegg kegg NA NA no no no no no no Mitophagy - animal Cell adhesion molecules 0 -0.571146245 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Cell adhesion molecules -0.703478261 -0.494071146 -0.42033462 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Cell adhesion molecules 0 0.682806324 0 kegg kegg NA NA up up up no no no Nicotinate and nicotinamide metabolism Cell adhesion molecules 0 0.425889328 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Cell adhesion molecules 0.41826087 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Cell adhesion molecules 0 -0.550395257 -0.570913771 kegg kegg NA NA no no no no no no One carbon pool by folate Cell adhesion molecules 0 -0.54743083 0 kegg kegg NA NA no no no no no no Oocyte meiosis Cell adhesion molecules -0.543478261 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Cell adhesion molecules 0 0.654150198 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Cell adhesion molecules -0.596521739 -0.54743083 -0.551093951 kegg kegg NA NA no no no no no no Oxidative phosphorylation Cell adhesion molecules -0.53826087 -0.418972332 0 kegg kegg NA NA no no no no no no p53 signaling pathway Cell adhesion molecules -0.559130435 -0.4743083 -0.645817246 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Cell adhesion molecules 0 0.416996047 0 kegg kegg NA NA no no dn no no no Pentose phosphate pathway Cell adhesion molecules 0.568695652 0.721343874 0 kegg kegg NA NA no no no no no no Phagosome Cell adhesion molecules 0.925217391 0.943675889 0.899099099 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Cell adhesion molecules -0.475652174 0 -0.480823681 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Cell adhesion molecules -0.414782609 0 0 yes kegg kegg NA NA no up up no no no Platinum drug resistance Cell adhesion molecules 0 0 -0.594079794 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Cell adhesion molecules 0 -0.723320158 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Cell adhesion molecules 0 0.557312253 0.472844273 kegg kegg NA NA no no no no no no Protein export Cell adhesion molecules -0.62173913 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Cell adhesion molecules 0 -0.502964427 0 kegg kegg NA NA no no no no no no Purine metabolism Cell adhesion molecules 0 -0.755928854 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Cell adhesion molecules 0 -0.450592885 0 kegg kegg NA NA no no no no no no Ribosome Cell adhesion molecules -0.526956522 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Cell adhesion molecules -0.447826087 -0.533596838 -0.437065637 kegg kegg NA NA no no no no no no RNA degradation Cell adhesion molecules -0.62173913 -0.42687747 0 kegg kegg NA NA no no no no no no RNA polymerase Cell adhesion molecules -0.52 -0.595849802 -0.466666667 kegg kegg NA NA no no no no no no Ruminococcus Cell adhesion molecules 0 0 0.426254826 acetate-producing Genus kegg 0.335 NA no no no no no no Selenocompound metabolism Cell adhesion molecules -0.567826087 -0.466403162 -0.553153153 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Cell adhesion molecules 0 0.698616601 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Cell adhesion molecules -0.64173913 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Cell adhesion molecules 0 -0.51284585 -0.425482625 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Cell adhesion molecules -0.504347826 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Cell adhesion molecules -0.663478261 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Cell adhesion molecules -0.52173913 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Cell adhesion molecules 0 -0.482213439 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Cell adhesion molecules 0 0 -0.463063063 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Cell adhesion molecules 0 -0.640316206 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Cell adhesion molecules -0.413043478 -0.423913043 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Cell adhesion molecules -0.420869565 -0.427865613 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Cell cycle 0 0.646245059 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Cell cycle 0 -0.563241107 -0.551608752 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Cell cycle 0 0.723320158 0.604633205 kegg kegg NA NA no no no no no no Antifolate resistance Cell cycle 0 0.716403162 0.433719434 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Cell cycle 0 0 -0.525353925 kegg kegg NA NA no no no no no no Arginine and proline metabolism Cell cycle 0 -0.664031621 -0.61029601 kegg kegg NA NA no up no no no no Arginine biosynthesis Cell cycle 0 -0.614624506 -0.683912484 kegg kegg NA NA no no no no no no Basal transcription factors Cell cycle 0.729565217 0.837944664 0.803346203 kegg kegg NA NA no no no no no no Base excision repair Cell cycle 0.73826087 0.85770751 0.714285714 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Cell cycle -0.437391304 -0.781620553 -0.808751609 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Cell cycle 0 0.70256917 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Cell cycle 0.423478261 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Cell cycle 0 0.641304348 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Cell cycle 0 0 0.436036036 kegg kegg NA NA no up up no no no cAMP signaling pathway Cell cycle 0 -0.56027668 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Cell cycle 0 0 -0.625482625 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Cell cycle 0 -0.884387352 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Cell cycle -0.435652174 -0.719367589 -0.563963964 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Cell cycle 0.422608696 0.604743083 0.423680824 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Cell cycle 0.683478261 0.602766798 0.573487773 kegg kegg NA NA no no no no no no DNA replication Cell cycle 0.783478261 0.842885375 0.650965251 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Cell cycle 0 0.609683794 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Cell cycle 0 0.419960474 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Cell cycle 0.429565217 0.435770751 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Cell cycle 0 0 0.471299871 kegg kegg NA NA no no no no no no Ether lipid metabolism Cell cycle 0 0.609683794 0.566795367 kegg kegg NA NA no no no no no no Fanconi anemia pathway Cell cycle 0.851304348 0.817193676 0.796911197 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Cell cycle 0 -0.597826087 -0.403861004 kegg kegg NA NA no no no no no no Folate biosynthesis Cell cycle 0.493043478 0.502964427 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Cell cycle 0 0 0.434234234 kegg kegg NA NA no no no no no no Glutathione metabolism Cell cycle 0 0.466403162 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Cell cycle 0 0 0.485456885 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Cell cycle 0 0 0.66048906 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Cell cycle 0 0.54743083 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Cell cycle -0.616521739 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Cell cycle 0 0.595849802 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Cell cycle 0 0 0.542599743 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Cell cycle -0.591304348 -0.615612648 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Cell cycle 0 0.648221344 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Cell cycle 0.633043478 0.565217391 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Cell cycle 0 -0.654150198 -0.710939511 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Cell cycle 0.423478261 0 0 kegg kegg NA NA no no no no no no Homologous recombination Cell cycle 0.782608696 0.621541502 0.793050193 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Cell cycle 0 0 0.597683398 kegg kegg NA NA no no no no no no Lysine degradation Cell cycle 0.437391304 0.674901186 0.763706564 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Cell cycle 0 0.5256917 0.718918919 kegg kegg NA NA no no no no no no MAPK signaling pathway Cell cycle 0.504347826 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Cell cycle 0 0.498023715 0 kegg kegg NA NA no no no no no no Mismatch repair Cell cycle 0.629565217 0.719367589 0.435263835 kegg kegg NA NA no no no no no no mRNA surveillance pathway Cell cycle 0.448695652 0.72826087 0.826254826 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Cell cycle 0.585217391 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Cell cycle 0.767826087 0.835968379 0.803861004 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Cell cycle 0 -0.683794466 -0.696525097 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Cell cycle 0 -0.456521739 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Cell cycle 0 -0.721343874 -0.720978121 kegg kegg NA NA no no no no no no Nitrogen metabolism Cell cycle -0.566956522 -0.637351779 -0.624967825 kegg kegg NA NA no no no no no no Nucleotide excision repair Cell cycle 0.815652174 0.866600791 0.657915058 kegg kegg NA NA no no no no no no One carbon pool by folate Cell cycle 0.790434783 0.860671937 0.715830116 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Cell cycle 0.628695652 0.685770751 0.832947233 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Cell cycle 0 -0.621541502 -0.561389961 kegg kegg NA NA no no dn no no no Paraprevotella Cell cycle 0 0.447554847 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Cell cycle 0.466086957 0.706521739 0.571428571 kegg kegg NA NA no no no no no no Pentose phosphate pathway Cell cycle -0.669565217 -0.839920949 -0.852767053 kegg kegg NA NA no no no no no no Phenylalanine metabolism Cell cycle 0 0.52173913 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Cell cycle 0.55826087 0.72826087 0.832689833 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Cell cycle -0.495652174 -0.483201581 0 kegg kegg NA NA no up up no no no Platinum drug resistance Cell cycle 0.616521739 0.583003953 0.642728443 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Cell cycle 0 0.461462451 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Cell cycle 0 -0.704545455 -0.661518662 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Cell cycle 0.553043478 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Cell cycle 0.540869565 0.518774704 0.441956242 kegg kegg NA NA no no no no no no Protein export Cell cycle 0.726086957 0.508893281 0.668983269 kegg kegg NA NA no no no no no no Purine metabolism Cell cycle 0 0.595849802 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Cell cycle 0 0.692687747 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Cell cycle 0.597391304 0.612648221 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Cell cycle -0.532173913 0 0 kegg kegg NA NA no no no no no no Ras signaling pathway Cell cycle 0 0.575098814 0.722007722 yes kegg kegg NA NA no up up no no no Retinol metabolism Cell cycle 0 0.650197628 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Cell cycle 0.833043478 0.934782609 0.894980695 kegg kegg NA NA no no no no no no RNA degradation Cell cycle 0.428695652 0.733201581 0.85997426 kegg kegg NA NA no no no no no no RNA polymerase Cell cycle 0.699130435 0.911067194 0.664350064 kegg kegg NA NA no no no no no no RNA transport Cell cycle 0.52173913 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Cell cycle 0.524347826 0.670948617 0.651480051 kegg kegg NA NA no no no no no no Sphingolipid metabolism Cell cycle -0.635652174 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Cell cycle 0 -0.555335968 0 kegg kegg NA NA no no no no no no Spliceosome Cell cycle 0.707826087 0.62944664 0.864350064 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Cell cycle 0 -0.562252964 -0.423680824 kegg kegg NA NA no no no no no no Steroid biosynthesis Cell cycle 0.596521739 0.536561265 0.54028314 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Cell cycle 0 0.446640316 0 kegg kegg NA NA no no no no no no Sulfur metabolism Cell cycle 0 0 -0.586615187 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Cell cycle 0.69826087 0.79743083 0.595109395 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Cell cycle 0.744347826 0.614624506 0.702445302 kegg kegg NA NA no no no no no no Thiamine metabolism Cell cycle 0 0.480237154 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Cell cycle 0 0.600790514 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Cell cycle 0.448695652 0.707509881 0.481338481 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Cell cycle 0.459130435 0.665019763 0.438095238 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Cell cycle 0.662608696 0.783596838 0.724324324 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Cell cycle 0 -0.524703557 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Cellular senescence 0 0 -0.571943372 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Cellular senescence 0 -0.416007905 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Cellular senescence 0 -0.558300395 0 kegg kegg NA NA no no no no no no Apoptosis Cellular senescence 0 0.81027668 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Cellular senescence 0 0 -0.566023166 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Cellular senescence -0.547826087 0 0 kegg kegg NA NA no no no no no no Basal transcription factors Cellular senescence -0.566086957 -0.604743083 0 kegg kegg NA NA no no no no no no Base excision repair Cellular senescence 0 -0.5 -0.446589447 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Cellular senescence 0.532173913 0.617588933 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Cellular senescence 0 -0.855731225 0 kegg kegg NA NA no no no no no no Butanoate metabolism Cellular senescence 0 -0.52173913 0 kegg kegg NA NA no no no no no no Cell cycle Cellular senescence -0.573043478 -0.641304348 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Cellular senescence 0 0.563241107 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Cellular senescence 0.435652174 0.556324111 0.486743887 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Cellular senescence 0 -0.506916996 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Cellular senescence 0 -0.535573123 0 kegg kegg NA NA no no no no no no DNA replication Cellular senescence -0.406956522 -0.572134387 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Cellular senescence 0 -0.51284585 0 kegg kegg NA NA no no no no no no Endocrine resistance Cellular senescence 0 -0.422924901 0 kegg kegg NA NA no no no no no no Endocytosis Cellular senescence 0.955652174 0.935770751 0.947232947 kegg kegg NA NA no no no no no no Ether lipid metabolism Cellular senescence -0.551304348 -0.726284585 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Cellular senescence -0.475652174 -0.552371542 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Cellular senescence 0 0.416007905 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Cellular senescence 0 0 -0.456628057 kegg kegg NA NA no no no no no no Galactose metabolism Cellular senescence 0 0.434782609 0 kegg kegg NA NA no no no no no no Glutathione metabolism Cellular senescence 0 -0.636363636 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Cellular senescence -0.530434783 0 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Cellular senescence 0 -0.720355731 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Cellular senescence 0.460869565 0.507905138 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Cellular senescence 0 0.533596838 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Cellular senescence -0.442608696 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Cellular senescence 0 -0.67687747 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Cellular senescence 0 0.429841897 0 kegg kegg NA NA no no no no no no Histidine metabolism Cellular senescence 0 0 -0.416731017 kegg kegg NA NA no no no no no no Homologous recombination Cellular senescence 0 -0.427865613 -0.514285714 kegg kegg NA NA no no no no no no Lysosome Cellular senescence 0 0.638339921 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Cellular senescence 0 -0.434782609 0 kegg kegg NA NA no no no no no no Mismatch repair Cellular senescence 0 -0.690711462 0 kegg kegg NA NA no no no no no no Mitophagy - animal Cellular senescence 0 -0.475296443 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Cellular senescence -0.522608696 -0.423913043 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Cellular senescence 0 -0.423913043 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Cellular senescence 0 -0.507905138 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Cellular senescence 0 0.575098814 0 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Cellular senescence 0 0.477272727 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Cellular senescence 0 0.522727273 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Cellular senescence 0.491304348 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Cellular senescence -0.450434783 -0.703557312 -0.532046332 kegg kegg NA NA no no no no no no One carbon pool by folate Cellular senescence -0.516521739 -0.666007905 0 kegg kegg NA NA no no no no no no Oocyte meiosis Cellular senescence 0 -0.433794466 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Cellular senescence -0.52 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Cellular senescence -0.436521739 0 -0.481853282 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Cellular senescence 0 0.422924901 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Cellular senescence 0 -0.5256917 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Cellular senescence 0.484347826 0.648221344 0 kegg kegg NA NA no no no no no no Phagosome Cellular senescence 0.815652174 0.861660079 0.652252252 kegg kegg NA NA no no no no no no Phenylalanine metabolism Cellular senescence 0 -0.415019763 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Cellular senescence 0 0.461462451 0 kegg kegg NA NA no up up no no no Platinum drug resistance Cellular senescence 0 0 -0.538996139 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Cellular senescence 0 -0.71541502 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Cellular senescence 0.431304348 0.56916996 0.484684685 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Cellular senescence -0.414782609 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Cellular senescence 0 -0.522727273 0 kegg kegg NA NA no no no no no no Protein export Cellular senescence -0.494782609 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Cellular senescence 0 -0.589920949 0 kegg kegg NA NA no no no no no no Purine metabolism Cellular senescence 0 -0.672924901 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Cellular senescence 0 -0.552371542 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Cellular senescence 0 -0.62055336 -0.453024453 kegg kegg NA NA no no no no no no Retinol metabolism Cellular senescence 0 -0.519762846 -0.410810811 kegg kegg NA NA no no no no no no Ribosome Cellular senescence 0 -0.414031621 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Cellular senescence -0.482608696 -0.578063241 0 kegg kegg NA NA no no no no no no RNA degradation Cellular senescence -0.48 -0.468379447 0 kegg kegg NA NA no no no no no no RNA polymerase Cellular senescence -0.432173913 -0.638339921 0 kegg kegg NA NA no no no no no no Sarcina Cellular senescence 0 0.422326513 0 Genus kegg 0.0703 NA no no no no no no Selenocompound metabolism Cellular senescence -0.519130435 -0.438735178 -0.446846847 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Cellular senescence 0 0.755928854 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Cellular senescence -0.673043478 -0.574110672 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Cellular senescence 0 -0.622529644 0 kegg kegg NA NA no no no no no no Sulfur metabolism Cellular senescence 0 -0.41798419 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Cellular senescence -0.416521739 -0.706521739 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Cellular senescence -0.436521739 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Cellular senescence -0.682608696 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Cellular senescence 0 -0.717391304 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Cellular senescence 0 -0.653162055 -0.456370656 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Cellular senescence -0.450434783 -0.586956522 -0.43989704 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Cellular senescence 0 -0.563241107 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Cellular senescence 0 -0.574110672 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Cellular senescence 0.513913043 0 0 kegg kegg NA NA no no no no no no Adherens junction Central carbon metabolism in cancer -0.527826087 0 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Central carbon metabolism in cancer 0 0 0.4996139 kegg kegg NA NA no no no no no no Alcoholism Central carbon metabolism in cancer 0 0 -0.444272844 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Central carbon metabolism in cancer 0.468695652 0 0.554697555 kegg kegg NA NA no no no no no no Alistipes Central carbon metabolism in cancer -0.420091342 0 0 Genus kegg 0.0114 NA no up no no no no Aminoacyl-tRNA biosynthesis Central carbon metabolism in cancer 0 0 0.466409266 kegg kegg NA NA no no no no no no Apoptosis Central carbon metabolism in cancer 0 0 -0.466924067 kegg kegg NA NA no no no no no no Apoptosis - multiple species Central carbon metabolism in cancer 0.449565217 0 0.543629344 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Central carbon metabolism in cancer 0 0 -0.624967825 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Central carbon metabolism in cancer 0 0 0.483655084 kegg kegg NA NA no no no no no no Autophagy - animal Central carbon metabolism in cancer 0.645217391 0 0.516602317 kegg kegg NA NA no no no no no no Autophagy - other Central carbon metabolism in cancer 0.453043478 0 0.582754183 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Central carbon metabolism in cancer -0.428695652 0 0 kegg kegg NA NA no no no no no no Basal transcription factors Central carbon metabolism in cancer 0 0 0.693436293 kegg kegg NA NA no no no no no no Base excision repair Central carbon metabolism in cancer 0.455652174 0 0.564478764 kegg kegg NA NA no no no no no no Bile secretion Central carbon metabolism in cancer 0 0 -0.435778636 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Central carbon metabolism in cancer 0 0 -0.416731017 kegg kegg NA NA no no no no no no Breast cancer Central carbon metabolism in cancer 0 0 0.422908623 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Central carbon metabolism in cancer 0.587826087 0 0.548005148 kegg kegg NA NA no no no no no no Cell cycle Central carbon metabolism in cancer 0 0 0.567567568 kegg kegg NA NA no no no no no no Chemokine signaling pathway Central carbon metabolism in cancer 0 0 -0.649163449 kegg kegg NA NA no no no no no no Cholinergic synapse Central carbon metabolism in cancer 0.515652174 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Central carbon metabolism in cancer 0 0 0.465894466 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Central carbon metabolism in cancer 0 0 0.498069498 kegg kegg NA NA no no no no no no Collinsella Central carbon metabolism in cancer 0 0 -0.425370233 Genus kegg 0.128 NA no no no no no no Colorectal cancer Central carbon metabolism in cancer 0 0 0.465894466 kegg kegg NA NA no no no no no no Complement and coagulation cascades Central carbon metabolism in cancer 0 0 -0.437580438 kegg kegg NA NA no no no no no no Coprococcus Central carbon metabolism in cancer 0.430434783 0 0 butyrate-producing Genus kegg 0.612 NA no no no no no no Cysteine and methionine metabolism Central carbon metabolism in cancer 0.499130435 0 0.568854569 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Central carbon metabolism in cancer 0 0 -0.543371943 kegg kegg NA NA no no no no no no DNA replication Central carbon metabolism in cancer 0 0 0.496525097 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Central carbon metabolism in cancer 0 0.549407115 0 kegg kegg NA NA no no no no no no Endometrial cancer Central carbon metabolism in cancer 0 0 0.503732304 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Central carbon metabolism in cancer 0 0 -0.528700129 kegg kegg NA NA no no no no no no ErbB signaling pathway Central carbon metabolism in cancer 0 0 0.535392535 kegg kegg NA NA no no no no no no Ether lipid metabolism Central carbon metabolism in cancer -0.426086957 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Central carbon metabolism in cancer 0 0 0.692664093 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Central carbon metabolism in cancer 0.474782609 0 0 kegg kegg NA NA no no no no no no Fatty acid degradation Central carbon metabolism in cancer 0.513043478 0 0 kegg kegg NA NA no no no no no no Ferroptosis Central carbon metabolism in cancer 0 0 -0.546203346 kegg kegg NA NA no no no no no no FoxO signaling pathway Central carbon metabolism in cancer 0.72173913 0 0.718918919 kegg kegg NA NA no no no no no no Gap junction Central carbon metabolism in cancer 0 0 -0.458944659 kegg kegg NA NA no no no no no no Gastric acid secretion Central carbon metabolism in cancer -0.54 0 0 kegg kegg NA NA no no no no no no Gastric cancer Central carbon metabolism in cancer 0 0 0.627284427 kegg kegg NA NA no no no no no no Gemmiger Central carbon metabolism in cancer 0 0.432245513 0 butyrate-producing Genus kegg 0.595 NA no no no no no no Glioma Central carbon metabolism in cancer 0 0 0.623166023 kegg kegg NA NA no no no no no no Glutathione metabolism Central carbon metabolism in cancer 0 0 -0.546460746 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Central carbon metabolism in cancer 0 0 0.480823681 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Central carbon metabolism in cancer 0 0 -0.427541828 kegg kegg NA NA no up no no no no Glycosaminoglycan degradation Central carbon metabolism in cancer 0 -0.496047431 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Central carbon metabolism in cancer -0.503478261 0 0 kegg kegg NA NA no no no no no no GnRH secretion Central carbon metabolism in cancer 0 0 0.465894466 kegg kegg NA NA no up up no no no Hedgehog signaling pathway Central carbon metabolism in cancer 0 0 0.593564994 kegg kegg NA NA no no no no no no Hepatitis B Central carbon metabolism in cancer 0.519130435 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Central carbon metabolism in cancer -0.410434783 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Central carbon metabolism in cancer 0.436521739 0.541501976 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Central carbon metabolism in cancer -0.535652174 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Central carbon metabolism in cancer 0 -0.4743083 0 kegg kegg NA NA no no no no no no Homologous recombination Central carbon metabolism in cancer 0.555652174 0 0.68030888 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Central carbon metabolism in cancer 0 0 -0.403861004 kegg kegg NA NA no no dn no no no Influenza A Central carbon metabolism in cancer -0.434782609 0 -0.421621622 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Central carbon metabolism in cancer 0 0 0.55984556 kegg kegg NA NA no no no no no no Insulin signaling pathway Central carbon metabolism in cancer 0 0.480237154 0.425482625 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Central carbon metabolism in cancer 0.452173913 0 0.423938224 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Central carbon metabolism in cancer 0 0 -0.51016731 kegg kegg NA NA no no dn no no no Legionellosis Central carbon metabolism in cancer 0.472173913 0.532608696 0 kegg kegg NA NA no no no no no no Leishmaniasis Central carbon metabolism in cancer 0 0.454545455 0 kegg kegg NA NA no no no no no no Long-term depression Central carbon metabolism in cancer 0 0 -0.43011583 kegg kegg NA NA no no no no no no Long-term potentiation Central carbon metabolism in cancer 0 0 0.411068211 kegg kegg NA NA no no up no no no Longevity regulating pathway - multiple species Central carbon metabolism in cancer 0.553043478 0 0 kegg kegg NA NA no no no no no no Lysine degradation Central carbon metabolism in cancer 0 0 0.517631918 kegg kegg NA NA no no no no no no MAPK signaling pathway Central carbon metabolism in cancer 0.540869565 0 0.547490347 kegg kegg NA NA no no no no no no Measles Central carbon metabolism in cancer 0.492173913 0 0 kegg kegg NA NA no no no no no no Melanoma Central carbon metabolism in cancer 0.440869565 0 0.451737452 kegg kegg NA NA no no no no no no MicroRNAs in cancer Central carbon metabolism in cancer 0 0 0.674131274 kegg kegg NA NA no no no no no no Mineral absorption Central carbon metabolism in cancer 0 0 -0.518661519 kegg kegg NA NA no no no no no no Morphine addiction Central carbon metabolism in cancer 0 0 -0.467181467 kegg kegg NA NA no up up no no no mRNA surveillance pathway Central carbon metabolism in cancer 0 0 0.493178893 kegg kegg NA NA no no no no no no mTOR signaling pathway Central carbon metabolism in cancer 0 0.52173913 0.409266409 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Central carbon metabolism in cancer 0 0 0.607722008 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Central carbon metabolism in cancer 0 0 -0.430888031 kegg kegg NA NA no no no no no no Necroptosis Central carbon metabolism in cancer 0 0 -0.463320463 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Central carbon metabolism in cancer 0 0 -0.455855856 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Central carbon metabolism in cancer 0.437391304 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Central carbon metabolism in cancer 0 0 0.538738739 kegg kegg NA NA no no no no no no One carbon pool by folate Central carbon metabolism in cancer 0 0 0.491634492 kegg kegg NA NA no no no no no no Oocyte meiosis Central carbon metabolism in cancer 0 0 0.543371943 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Central carbon metabolism in cancer 0 0 0.613899614 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Central carbon metabolism in cancer 0 0 -0.469498069 kegg kegg NA NA no up up no no no Oxytocin signaling pathway Central carbon metabolism in cancer 0 0 -0.409266409 kegg kegg NA NA no no no no no no p53 signaling pathway Central carbon metabolism in cancer 0 0 0.518918919 kegg kegg NA NA no no no no no no Pancreatic cancer Central carbon metabolism in cancer 0 0.463438735 0.452767053 kegg kegg NA NA no no no no no no Parabacteroides Central carbon metabolism in cancer 0 0 -0.473003412 Genus kegg 4.19E-05 NA no up up no no no Parkinson disease Central carbon metabolism in cancer 0 0 -0.43011583 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Central carbon metabolism in cancer 0 0 -0.480823681 kegg kegg NA NA no no no no no no Pathways in cancer Central carbon metabolism in cancer 0 0 0.403861004 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Central carbon metabolism in cancer 0 0 -0.440669241 kegg kegg NA NA no no no no no no Peroxisome Central carbon metabolism in cancer 0.444347826 0 0 kegg kegg NA NA no no no no no no Phagosome Central carbon metabolism in cancer 0 0 -0.496267696 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Central carbon metabolism in cancer 0 0 0.595109395 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Central carbon metabolism in cancer 0.62173913 0.657114625 0.618790219 yes kegg kegg NA NA no up up no no no Platelet activation Central carbon metabolism in cancer -0.48 0 -0.434749035 kegg kegg NA NA no no no no no no Platinum drug resistance Central carbon metabolism in cancer 0.57826087 0 0.693436293 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Central carbon metabolism in cancer 0 0 -0.459202059 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Central carbon metabolism in cancer 0.766086957 0 0.675675676 kegg kegg NA NA no no no no no no Propanoate metabolism Central carbon metabolism in cancer 0.56173913 0 0.546460746 kegg kegg NA NA no no no no no no Protein digestion and absorption Central carbon metabolism in cancer 0 0 0.484427284 yes kegg kegg NA NA no up up no no no Proteoglycans in cancer Central carbon metabolism in cancer 0 0.448616601 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Central carbon metabolism in cancer 0 0 0.47979408 kegg kegg NA NA no no no no no no Pyruvate metabolism Central carbon metabolism in cancer 0.426956522 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Central carbon metabolism in cancer 0 0 -0.525611326 kegg kegg NA NA no no no no no no Relaxin signaling pathway Central carbon metabolism in cancer 0 0 -0.421364221 kegg kegg NA NA no no no no no no Renal cell carcinoma Central carbon metabolism in cancer 0 0.537549407 0.446846847 kegg kegg NA NA no no no no no no Retinol metabolism Central carbon metabolism in cancer 0 0 0.490862291 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Central carbon metabolism in cancer 0 0 0.675418275 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Central carbon metabolism in cancer 0.433043478 0 0 kegg kegg NA NA no no no no no no RNA degradation Central carbon metabolism in cancer 0 0 0.581981982 kegg kegg NA NA no no no no no no RNA polymerase Central carbon metabolism in cancer 0 0 0.414671815 kegg kegg NA NA no no no no no no RNA transport Central carbon metabolism in cancer 0.493913043 0.554347826 0.413642214 kegg kegg NA NA no no no no no no Selenocompound metabolism Central carbon metabolism in cancer 0 0 0.66023166 kegg kegg NA NA no no no no no no Serotonergic synapse Central carbon metabolism in cancer 0 -0.482213439 -0.611840412 kegg kegg NA NA no no no no no no Shigellosis Central carbon metabolism in cancer 0 0 -0.414157014 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Central carbon metabolism in cancer 0 0 0.608751609 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Central carbon metabolism in cancer 0 0 0.429343629 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Central carbon metabolism in cancer 0.433913043 0.486166008 0.655598456 kegg kegg NA NA no no no no no no Spliceosome Central carbon metabolism in cancer 0.609565217 0 0.702702703 kegg kegg NA NA no no no no no no Sulfur metabolism Central carbon metabolism in cancer 0 0 -0.403861004 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Central carbon metabolism in cancer 0 0 0.521235521 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Central carbon metabolism in cancer 0.573913043 0 0.502445302 kegg kegg NA NA no no no no no no Taste transduction Central carbon metabolism in cancer 0 0 0.483140283 kegg kegg NA NA no no up no no no Terpenoid backbone biosynthesis Central carbon metabolism in cancer 0 0 0.493178893 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Central carbon metabolism in cancer -0.468695652 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Central carbon metabolism in cancer 0 0 -0.567310167 kegg kegg NA NA no no no no no no Tight junction Central carbon metabolism in cancer -0.62 0 -0.433976834 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Central carbon metabolism in cancer 0 0 -0.416731017 yes kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Central carbon metabolism in cancer 0.513043478 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Central carbon metabolism in cancer 0 0 0.545173745 kegg kegg NA NA no up no no no no Type I diabetes mellitus Central carbon metabolism in cancer 0 0 -0.443243243 kegg kegg NA NA no no no no no no Type II diabetes mellitus Central carbon metabolism in cancer 0.486086957 0 0.423680824 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Central carbon metabolism in cancer 0 0 0.406949807 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Central carbon metabolism in cancer 0 0 0.465379665 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Central carbon metabolism in cancer 0 0 0.665894466 kegg kegg NA NA no no no no no no Vibrio cholerae infection Central carbon metabolism in cancer -0.513043478 0 -0.502702703 kegg kegg NA NA no no no no no no Viral carcinogenesis Central carbon metabolism in cancer 0 0 -0.403088803 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Central carbon metabolism in cancer 0 0 -0.607979408 kegg kegg NA NA no no no no no no Wnt signaling pathway Central carbon metabolism in cancer 0 0 0.416988417 kegg kegg NA NA no no no no no no Yersinia infection Central carbon metabolism in cancer 0 0 -0.48030888 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism cGMP-PKG signaling pathway -0.716521739 -0.674901186 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" cGMP-PKG signaling pathway 0.446086957 0.721343874 0 kegg kegg NA NA no no no no no no Alistipes cGMP-PKG signaling pathway -0.47424033 0 0 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism cGMP-PKG signaling pathway 0 0.448616601 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis cGMP-PKG signaling pathway -0.508695652 -0.608695652 -0.525868726 kegg kegg NA NA no no no no no no Antifolate resistance cGMP-PKG signaling pathway 0 -0.566205534 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism cGMP-PKG signaling pathway 0.44173913 0.792490119 0 kegg kegg NA NA no up no no no no Arginine biosynthesis cGMP-PKG signaling pathway 0.476521739 0.747035573 0 kegg kegg NA NA no no no no no no Basal transcription factors cGMP-PKG signaling pathway 0 -0.694664032 0 kegg kegg NA NA no no no no no no Base excision repair cGMP-PKG signaling pathway 0 -0.661067194 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism cGMP-PKG signaling pathway -0.433913043 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids cGMP-PKG signaling pathway 0 0.877470356 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors cGMP-PKG signaling pathway -0.74 -0.645256917 -0.445817246 kegg kegg NA NA no no no no no no Butanoate metabolism cGMP-PKG signaling pathway -0.60173913 -0.585968379 0 kegg kegg NA NA no no no no no no Calcium signaling pathway cGMP-PKG signaling pathway 0 -0.48715415 0 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) cGMP-PKG signaling pathway -0.502608696 -0.568181818 0 kegg kegg NA NA no no no no no no Clostridium cGMP-PKG signaling pathway 0 0 0.438757958 Genus kegg 0.925 NA no no no no no no Cysteine and methionine metabolism cGMP-PKG signaling pathway 0 -0.52173913 -0.408494208 kegg kegg NA NA no no no no no no DNA replication cGMP-PKG signaling pathway 0 -0.782608696 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 cGMP-PKG signaling pathway 0 -0.633399209 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes cGMP-PKG signaling pathway 0 -0.51284585 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance cGMP-PKG signaling pathway 0 -0.506916996 0 kegg kegg NA NA no no no no no no Ether lipid metabolism cGMP-PKG signaling pathway 0 -0.647233202 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway cGMP-PKG signaling pathway 0 -0.65513834 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis cGMP-PKG signaling pathway 0.529565217 0.781620553 0 kegg kegg NA NA no no no no no no Fatty acid degradation cGMP-PKG signaling pathway 0 0.551383399 0 kegg kegg NA NA no no no no no no Fatty acid metabolism cGMP-PKG signaling pathway 0 0.64229249 0 kegg kegg NA NA no no no no no no Folate biosynthesis cGMP-PKG signaling pathway 0 -0.561264822 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism cGMP-PKG signaling pathway -0.406956522 0 0 kegg kegg NA NA no no no no no no Galactose metabolism cGMP-PKG signaling pathway 0 0.443675889 0 kegg kegg NA NA no no no no no no Glutathione metabolism cGMP-PKG signaling pathway -0.592173913 -0.56027668 -0.462290862 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" cGMP-PKG signaling pathway -0.733913043 -0.568181818 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis cGMP-PKG signaling pathway -0.468695652 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate cGMP-PKG signaling pathway 0.472173913 0.47826087 0.494465894 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin cGMP-PKG signaling pathway -0.447826087 -0.511857708 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate cGMP-PKG signaling pathway 0 -0.448616601 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation cGMP-PKG signaling pathway 0 0.597826087 0.441441441 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series cGMP-PKG signaling pathway 0 -0.56916996 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis cGMP-PKG signaling pathway 0 -0.545454545 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism cGMP-PKG signaling pathway 0 0.787549407 0 kegg kegg NA NA no no no no no no Homologous recombination cGMP-PKG signaling pathway 0 -0.460474308 -0.402316602 kegg kegg NA NA no no no no no no Lysine degradation cGMP-PKG signaling pathway 0 -0.600790514 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis cGMP-PKG signaling pathway 0 -0.555335968 0 kegg kegg NA NA no no no no no no MAPK signaling pathway cGMP-PKG signaling pathway 0.499130435 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 cGMP-PKG signaling pathway 0 -0.518774704 0 kegg kegg NA NA no no no no no no Mismatch repair cGMP-PKG signaling pathway 0 -0.539525692 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway cGMP-PKG signaling pathway 0 -0.869565217 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis cGMP-PKG signaling pathway 0 -0.83201581 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism cGMP-PKG signaling pathway 0.610434783 0.850790514 0.579150579 kegg kegg NA NA no no no no no no Nitrogen metabolism cGMP-PKG signaling pathway 0.407826087 0.73715415 0 kegg kegg NA NA no no no no no no Non-homologous end-joining cGMP-PKG signaling pathway -0.444347826 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair cGMP-PKG signaling pathway 0 -0.714426877 -0.448648649 kegg kegg NA NA no no no no no no One carbon pool by folate cGMP-PKG signaling pathway 0 -0.721343874 -0.483655084 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis cGMP-PKG signaling pathway 0 -0.593873518 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation cGMP-PKG signaling pathway 0 -0.616600791 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis cGMP-PKG signaling pathway 0.693043478 0.805335968 0.458172458 kegg kegg NA NA no no dn no no no Paraprevotella cGMP-PKG signaling pathway 0 -0.535149679 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions cGMP-PKG signaling pathway 0 -0.72826087 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway cGMP-PKG signaling pathway 0 0.918972332 0.422651223 kegg kegg NA NA no no no no no no Phenylalanine metabolism cGMP-PKG signaling pathway -0.58173913 -0.446640316 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism cGMP-PKG signaling pathway -0.689565217 -0.53458498 -0.436036036 kegg kegg NA NA no no no no no no PPAR signaling pathway cGMP-PKG signaling pathway 0 0.772727273 0.667953668 kegg kegg NA NA no no no no no no Propanoate metabolism cGMP-PKG signaling pathway 0 -0.442687747 0 kegg kegg NA NA no no no no no no Protein export cGMP-PKG signaling pathway 0 -0.646245059 0 kegg kegg NA NA no no no no no no Purine metabolism cGMP-PKG signaling pathway -0.544347826 -0.646245059 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism cGMP-PKG signaling pathway 0 -0.626482213 0 kegg kegg NA NA no no no no no no Pyruvate metabolism cGMP-PKG signaling pathway 0 -0.59486166 -0.495495495 kegg kegg NA NA no no no no no no Ras signaling pathway cGMP-PKG signaling pathway 0 -0.553359684 0 yes kegg kegg NA NA no up up no no no Retinol metabolism cGMP-PKG signaling pathway 0 -0.443675889 0 kegg kegg NA NA no no no no no no Ribosome cGMP-PKG signaling pathway 0 -0.53458498 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes cGMP-PKG signaling pathway 0 -0.82312253 0 kegg kegg NA NA no no no no no no RNA degradation cGMP-PKG signaling pathway 0 -0.824110672 0 kegg kegg NA NA no no no no no no RNA polymerase cGMP-PKG signaling pathway 0 -0.894268775 0 kegg kegg NA NA no no no no no no RNA transport cGMP-PKG signaling pathway 0 -0.441699605 0 kegg kegg NA NA no no no no no no Ruminococcus cGMP-PKG signaling pathway -0.531304348 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Selenocompound metabolism cGMP-PKG signaling pathway 0 -0.450592885 0 kegg kegg NA NA no no no no no no Slackia cGMP-PKG signaling pathway 0 0 -0.463976098 Genus kegg 0.94 NA no no no no no no Spliceosome cGMP-PKG signaling pathway 0 -0.470355731 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism cGMP-PKG signaling pathway 0 0.736166008 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies cGMP-PKG signaling pathway 0 -0.596837945 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis cGMP-PKG signaling pathway 0 -0.469367589 0 kegg kegg NA NA no no no no no no Thiamine metabolism cGMP-PKG signaling pathway 0 -0.453557312 0 kegg kegg NA NA no no no no no no Tryptophan metabolism cGMP-PKG signaling pathway -0.417391304 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism cGMP-PKG signaling pathway -0.415652174 -0.48715415 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis cGMP-PKG signaling pathway 0 -0.549407115 -0.465379665 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" cGMP-PKG signaling pathway -0.471304348 -0.583003953 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis cGMP-PKG signaling pathway 0 -0.718379447 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Chagas disease -0.476521739 -0.698616601 0 kegg kegg NA NA no no no no no no Adherens junction Chagas disease 0 -0.556324111 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Chagas disease 0.419130435 0.802371542 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Chagas disease 0.445217391 0 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Chagas disease 0 0.690711462 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Chagas disease 0 0.709486166 0 kegg kegg NA NA no no no no no no Alcoholism Chagas disease 0 0 0.503732304 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Chagas disease 0.594782609 0.415019763 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Chagas disease 0 0 -0.471814672 kegg kegg NA NA no no no no no no Alzheimer disease Chagas disease 0 -0.466403162 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Chagas disease -0.432173913 0 -0.71016731 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Chagas disease 0 -0.600790514 -0.400772201 kegg kegg NA NA no no no no no no Amphetamine addiction Chagas disease 0 -0.572134387 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Chagas disease 0 -0.514822134 0 kegg kegg NA NA no no no no no no Antifolate resistance Chagas disease 0 -0.428853755 -0.423423423 kegg kegg NA NA no no no no no no Apelin signaling pathway Chagas disease 0 -0.688735178 0 kegg kegg NA NA no no no no no no Apoptosis Chagas disease 0 0.79743083 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Chagas disease 0 0 -0.479279279 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Chagas disease -0.542608696 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Chagas disease 0 0.670948617 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Chagas disease 0 0.731225296 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Chagas disease -0.473913043 -0.529644269 -0.612355212 kegg kegg NA NA no no no no no no Autophagy - animal Chagas disease 0.52 0.804347826 0 kegg kegg NA NA no no no no no no Autophagy - other Chagas disease 0.45826087 0 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Chagas disease 0 0.787549407 0.424453024 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Chagas disease 0 -0.484189723 0 kegg kegg NA NA no no no no no no Bacteroides Chagas disease 0 -0.473320158 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Chagas disease 0 -0.496047431 0 kegg kegg NA NA no no no no no no Base excision repair Chagas disease 0 -0.461462451 -0.516087516 kegg kegg NA NA no no no no no no beta-Alanine metabolism Chagas disease -0.605217391 -0.670948617 -0.634749035 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Chagas disease 0 0.473320158 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Chagas disease -0.433913043 -0.556324111 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Chagas disease -0.550434783 -0.598814229 -0.596911197 kegg kegg NA NA no no no no no no Butanoate metabolism Chagas disease -0.597391304 -0.909090909 -0.568854569 kegg kegg NA NA no no no no no no Butyricimonas Chagas disease 0.45902689 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no C-type lectin receptor signaling pathway Chagas disease 0.58173913 0.824110672 0.461261261 kegg kegg NA NA no no no no no no Calcium signaling pathway Chagas disease 0 0 0.453796654 kegg kegg NA NA no up up no no no cAMP signaling pathway Chagas disease 0.640869565 0.803359684 0.717374517 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Chagas disease 0.703478261 0.539525692 0 kegg kegg NA NA no no no no no no Carbon metabolism Chagas disease -0.437391304 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Chagas disease 0 -0.435770751 0 kegg kegg NA NA no no up no no no Cell cycle Chagas disease 0 -0.624505929 0 kegg kegg NA NA no no no no no no Cellular senescence Chagas disease 0 0.564229249 0.561904762 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Chagas disease 0 0.555335968 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Chagas disease 0.63826087 0.623517787 0.510939511 kegg kegg NA NA no no no no no no Cholinergic synapse Chagas disease 0.480869565 0 0 kegg kegg NA NA no no no no no no Circadian entrainment Chagas disease 0 -0.507905138 0 kegg kegg NA NA no up up no no no Circadian rhythm Chagas disease 0.406956522 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Chagas disease -0.611304348 -0.911067194 -0.427799228 kegg kegg NA NA no no no no no no Clostridium Chagas disease -0.449228104 0 0 Genus kegg 0.925 NA no no no no no no Cocaine addiction Chagas disease 0 0 0.611068211 kegg kegg NA NA no no no no no no Complement and coagulation cascades Chagas disease 0 0.440711462 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Chagas disease 0 0 0.453796654 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Chagas disease 0 -0.902173913 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Chagas disease 0.566086957 0.70256917 0.770913771 kegg kegg NA NA no no no no no no DNA replication Chagas disease 0 -0.867588933 -0.477734878 kegg kegg NA NA no no no no no no Dopaminergic synapse Chagas disease 0.435652174 -0.427865613 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Chagas disease 0 -0.913043478 -0.457915058 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Chagas disease -0.646956522 -0.862648221 -0.42033462 kegg kegg NA NA no no no no no no ECM-receptor interaction Chagas disease 0 -0.554347826 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Chagas disease 0 -0.567193676 0 kegg kegg NA NA no no no no no no Endocytosis Chagas disease 0 0 0.489060489 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Chagas disease 0.520869565 0.805335968 0.708108108 kegg kegg NA NA no no no no no no ErbB signaling pathway Chagas disease 0.479130435 0.517786561 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Chagas disease 0 -0.758893281 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Chagas disease 0 -0.433794466 -0.563449163 kegg kegg NA NA no no no no no no Fanconi anemia pathway Chagas disease 0 -0.435770751 -0.531016731 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Chagas disease 0 0.669960474 0 kegg kegg NA NA no no no no no no Fatty acid degradation Chagas disease 0 0 -0.403603604 kegg kegg NA NA no no no no no no Fatty acid elongation Chagas disease -0.656521739 -0.663043478 -0.540797941 kegg kegg NA NA no no no no no no Fatty acid metabolism Chagas disease -0.408695652 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Chagas disease 0 0.809288538 0 kegg kegg NA NA no no no no no no Ferroptosis Chagas disease 0 0.4743083 0 kegg kegg NA NA no no no no no no Focal adhesion Chagas disease 0 -0.644268775 0 kegg kegg NA NA no up up no no no Folate biosynthesis Chagas disease 0 -0.486166008 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Chagas disease 0 0.43083004 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Chagas disease 0 0.453557312 0 kegg kegg NA NA no no no no no no GABAergic synapse Chagas disease 0 0.528656126 0 kegg kegg NA NA no up up no no no Galactose metabolism Chagas disease -0.426086957 0 -0.465379665 kegg kegg NA NA no no no no no no Gap junction Chagas disease 0 0 0.411583012 kegg kegg NA NA no no no no no no Gastric acid secretion Chagas disease 0 -0.567193676 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Chagas disease 0 -0.538537549 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Chagas disease 0 0.543478261 0 kegg kegg NA NA no up up no no no Glutathione metabolism Chagas disease 0 -0.548418972 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Chagas disease 0 0 -0.453024453 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Chagas disease -0.41826087 -0.750988142 -0.423166023 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Chagas disease 0 0.809288538 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Chagas disease -0.466086957 -0.508893281 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Chagas disease -0.442608696 -0.485177866 -0.466409266 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Chagas disease 0 0.5 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Chagas disease 0 0.717391304 0 kegg kegg NA NA no no no no no no GnRH secretion Chagas disease 0.522608696 0.619565217 0 kegg kegg NA NA no up up no no no GnRH signaling pathway Chagas disease 0 0 0.417245817 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Chagas disease 0.50173913 0.564229249 0.580694981 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Chagas disease 0 -0.440711462 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Chagas disease -0.565217391 -0.690711462 -0.607722008 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Chagas disease 0 -0.600790514 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Chagas disease 0 -0.665019763 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Chagas disease 0 0.490118577 0 kegg kegg NA NA no no no no no no Histidine metabolism Chagas disease -0.555652174 0 -0.624195624 kegg kegg NA NA no no no no no no Homologous recombination Chagas disease 0 0 -0.52972973 kegg kegg NA NA no no no no no no Huntington disease Chagas disease 0 -0.448616601 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Chagas disease 0 0.570158103 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Chagas disease 0 -0.515810277 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Chagas disease 0 0 -0.546975547 kegg kegg NA NA no no no no no no Insulin resistance Chagas disease 0.529565217 0.813241107 0 kegg kegg NA NA no no no no no no Insulin secretion Chagas disease 0 0 0.476447876 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Chagas disease 0 -0.674901186 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Chagas disease 0 0.658102767 0 kegg kegg NA NA no no no no no no Long-term depression Chagas disease 0 0.473320158 0.550836551 kegg kegg NA NA no no no no no no Long-term potentiation Chagas disease 0 -0.744071146 0 kegg kegg NA NA no no up no no no Maturity onset diabetes of the young Chagas disease 0 0 -0.472586873 kegg kegg NA NA no up no no no no Melanogenesis Chagas disease 0 -0.468379447 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Chagas disease -0.48 -0.908102767 -0.427541828 kegg kegg NA NA no no no no no no Mismatch repair Chagas disease -0.483478261 -0.843873518 -0.509137709 kegg kegg NA NA no no no no no no Morphine addiction Chagas disease 0 0 0.406692407 kegg kegg NA NA no up up no no no mRNA surveillance pathway Chagas disease 0 -0.41798419 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Chagas disease 0 -0.563241107 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Chagas disease 0 -0.763833992 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Chagas disease 0 0.453557312 0.48030888 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Chagas disease 0.650434783 0.751976285 0.623423423 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Chagas disease 0 0.852766798 0.432432432 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Chagas disease 0 0.718379447 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Chagas disease 0 0.730237154 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Chagas disease 0 0.739130435 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Chagas disease -0.606956522 -0.783596838 0 kegg kegg NA NA no no no no no no Notch signaling pathway Chagas disease 0 0.46541502 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Chagas disease -0.434782609 -0.791501976 -0.598198198 kegg kegg NA NA no no no no no no One carbon pool by folate Chagas disease -0.425217391 -0.800395257 -0.54980695 kegg kegg NA NA no no no no no no Oocyte meiosis Chagas disease 0 -0.820158103 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Chagas disease 0 0.671936759 0.421106821 kegg kegg NA NA no no no no no no Other glycan degradation Chagas disease 0 0 -0.423680824 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Chagas disease 0 0 -0.436293436 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Chagas disease 0 0 0.403346203 kegg kegg NA NA no up up no no no Oxidative phosphorylation Chagas disease 0 -0.459486166 0 kegg kegg NA NA no no no no no no p53 signaling pathway Chagas disease 0 0 -0.431145431 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Chagas disease 0 0.492094862 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Chagas disease 0.489565217 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Chagas disease -0.55826087 -0.863636364 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Chagas disease 0 0.414031621 0 kegg kegg NA NA no no no no no no Peroxisome Chagas disease 0 0.436758893 0 kegg kegg NA NA no no no no no no Pertussis Chagas disease 0 0.480237154 0 kegg kegg NA NA no no dn no no no Phenylalanine metabolism Chagas disease -0.568695652 -0.807312253 -0.408236808 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Chagas disease 0.51826087 0.874505929 0.53024453 kegg kegg NA NA no up up no no no Phototransduction Chagas disease 0 -0.709486166 0 kegg kegg NA NA no no no no no no Platelet activation Chagas disease 0 -0.421936759 0 kegg kegg NA NA no no no no no no Platinum drug resistance Chagas disease 0 0 -0.493693694 kegg kegg NA NA no no no no no no PPAR signaling pathway Chagas disease 0 0.7243083 0.561389961 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Chagas disease -0.651304348 -0.693675889 -0.451994852 kegg kegg NA NA no no no no no no Prion disease Chagas disease 0 -0.563241107 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Chagas disease 0.612173913 0.720355731 0 kegg kegg NA NA no no no no no no Propanoate metabolism Chagas disease 0 -0.873517787 0 kegg kegg NA NA no no no no no no Proteasome Chagas disease 0 -0.756916996 0 kegg kegg NA NA no no no no no no Protein export Chagas disease 0 -0.703557312 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Chagas disease 0 -0.669960474 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Chagas disease 0 -0.863636364 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Chagas disease -0.62 -0.760869565 -0.528442728 kegg kegg NA NA no no no no no no Pyruvate metabolism Chagas disease -0.446086957 -0.897233202 -0.46048906 kegg kegg NA NA no no no no no no Ras signaling pathway Chagas disease 0 -0.705533597 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Chagas disease 0 -0.650197628 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Chagas disease 0.74 0.863636364 0.653539254 kegg kegg NA NA no no no no no no Renin secretion Chagas disease 0 -0.581027668 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Chagas disease 0 0.444664032 0 kegg kegg NA NA no no no no no no Retinol metabolism Chagas disease 0 -0.681818182 -0.603088803 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Chagas disease 0 -0.541501976 0 kegg kegg NA NA no no up no no no Ribosome Chagas disease 0 -0.535573123 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Chagas disease 0 -0.617588933 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Chagas disease 0.597391304 0.864624506 0.537194337 kegg kegg NA NA no no no no no no RNA degradation Chagas disease 0 -0.664031621 0 kegg kegg NA NA no no no no no no RNA polymerase Chagas disease 0 -0.669960474 -0.416731017 kegg kegg NA NA no no no no no no RNA transport Chagas disease 0 -0.552371542 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Chagas disease 0 0 -0.606949807 kegg kegg NA NA no no no no no no Serotonergic synapse Chagas disease 0 0 0.51016731 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Chagas disease 0.431304348 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Chagas disease 0 0.468379447 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Chagas disease 0.515652174 0.459486166 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Chagas disease 0.428695652 -0.432806324 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Chagas disease 0 0.519762846 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Chagas disease 0 -0.787549407 -0.533848134 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Chagas disease -0.53826087 -0.795454545 -0.48983269 kegg kegg NA NA no no no no no no Sulfur metabolism Chagas disease -0.530434783 -0.425889328 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Chagas disease -0.466086957 -0.765810277 -0.477220077 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Chagas disease 0.462608696 0.477272727 0.403861004 kegg kegg NA NA no no no no no no Taste transduction Chagas disease 0 -0.650197628 -0.402831403 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Chagas disease 0 0.508893281 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Chagas disease 0 -0.509881423 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Chagas disease 0 -0.710474308 0 kegg kegg NA NA no no no no no no Thermogenesis Chagas disease 0 -0.530632411 0 kegg kegg NA NA no no no no no no Thiamine metabolism Chagas disease 0 -0.685770751 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Chagas disease 0 -0.436758893 0 kegg kegg NA NA no no no no no no Tight junction Chagas disease -0.436521739 -0.508893281 0 kegg kegg NA NA no no no no no no TNF signaling pathway Chagas disease 0.848695652 0.873517787 0.722779923 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Chagas disease 0.846956522 0.871541502 0.757786358 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Chagas disease -0.692173913 -0.829051383 -0.534620335 kegg kegg NA NA no up no no no no Type II diabetes mellitus Chagas disease 0.646086957 0.618577075 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Chagas disease -0.568695652 -0.889328063 -0.579407979 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Chagas disease -0.72173913 -0.773715415 -0.579150579 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Chagas disease -0.629565217 -0.85770751 -0.642728443 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Chagas disease 0 -0.648221344 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Chagas disease 0 -0.428853755 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Chagas disease 0.512173913 0.600790514 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Chagas disease 0 -0.431818182 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Chagas disease 0.46 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Chagas disease 0 -0.692687747 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Chemical carcinogenesis - DNA adducts -0.505217391 -0.516798419 -0.591505792 kegg kegg NA NA no no up no no no Aldosterone synthesis and secretion Chemical carcinogenesis - DNA adducts -0.653913043 -0.583992095 -0.547747748 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Chemical carcinogenesis - DNA adducts 0.667826087 0.549407115 0.551608752 kegg kegg NA NA no no no no no no Alzheimer disease Chemical carcinogenesis - DNA adducts -0.459130435 -0.5 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Chemical carcinogenesis - DNA adducts 0.813043478 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Chemical carcinogenesis - DNA adducts 0.432173913 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Chemical carcinogenesis - DNA adducts -0.475652174 0 -0.523809524 kegg kegg NA NA no no no no no no AMPK signaling pathway Chemical carcinogenesis - DNA adducts 0 -0.505928854 -0.457657658 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Chemical carcinogenesis - DNA adducts -0.526956522 -0.502964427 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Chemical carcinogenesis - DNA adducts 0.450434783 0 0 kegg kegg NA NA no no no no no no Apoptosis Chemical carcinogenesis - DNA adducts 0 0 0.514028314 kegg kegg NA NA no no no no no no Arginine and proline metabolism Chemical carcinogenesis - DNA adducts 0.606956522 0.488142292 0.462290862 kegg kegg NA NA no up no no no no Axon guidance Chemical carcinogenesis - DNA adducts -0.48173913 0 0 kegg kegg NA NA no up up no no no Basal transcription factors Chemical carcinogenesis - DNA adducts 0 0 -0.422651223 kegg kegg NA NA no no no no no no beta-Alanine metabolism Chemical carcinogenesis - DNA adducts 0.576521739 0.562252964 0 kegg kegg NA NA no no no no no no Bile secretion Chemical carcinogenesis - DNA adducts -0.435652174 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Chemical carcinogenesis - DNA adducts 0.573043478 0.504940711 0.613899614 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Chemical carcinogenesis - DNA adducts 0.566956522 0.501976285 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Chemical carcinogenesis - DNA adducts -0.74173913 -0.686758893 -0.55984556 kegg kegg NA NA no up up no no no cAMP signaling pathway Chemical carcinogenesis - DNA adducts -0.490434783 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Chemical carcinogenesis - DNA adducts 0.610434783 0.434782609 0.723294723 kegg kegg NA NA no no no no no no Cardiac muscle contraction Chemical carcinogenesis - DNA adducts -0.47826087 -0.523715415 0 kegg kegg NA NA no no up no no no Cell cycle Chemical carcinogenesis - DNA adducts 0 0 -0.584555985 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Chemical carcinogenesis - DNA adducts 0 0.496047431 0.427027027 kegg kegg NA NA no no no no no no Cholesterol metabolism Chemical carcinogenesis - DNA adducts 0 0 0.51016731 yes kegg kegg NA NA no no up no no no Circadian rhythm Chemical carcinogenesis - DNA adducts -0.460869565 -0.668972332 -0.522779923 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Chemical carcinogenesis - DNA adducts 0.483478261 0 0 kegg kegg NA NA no no no no no no Cocaine addiction Chemical carcinogenesis - DNA adducts -0.606086957 -0.532608696 -0.410810811 kegg kegg NA NA no no no no no no Collecting duct acid secretion Chemical carcinogenesis - DNA adducts 0 0.612648221 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Chemical carcinogenesis - DNA adducts 0.466086957 0.437747036 0.491377091 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Chemical carcinogenesis - DNA adducts -0.48 -0.414031621 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Chemical carcinogenesis - DNA adducts -0.582608696 -0.468379447 -0.471042471 kegg kegg NA NA no no up no no no Cushing syndrome Chemical carcinogenesis - DNA adducts -0.631304348 -0.583003953 -0.649420849 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Chemical carcinogenesis - DNA adducts 0.473043478 0 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Chemical carcinogenesis - DNA adducts 0 0.550395257 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Chemical carcinogenesis - DNA adducts 0 0 -0.518404118 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Chemical carcinogenesis - DNA adducts 0.733043478 0 0.653796654 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Chemical carcinogenesis - DNA adducts 0.73826087 0 0.554697555 kegg kegg NA NA no no no no no no ECM-receptor interaction Chemical carcinogenesis - DNA adducts 0 0 -0.45971686 kegg kegg NA NA no up up no no no Endocrine and other factor-regulated calcium reabsorption Chemical carcinogenesis - DNA adducts -0.595652174 -0.476284585 -0.463320463 kegg kegg NA NA no no no no no no Endocrine resistance Chemical carcinogenesis - DNA adducts -0.676521739 -0.470355731 -0.556756757 kegg kegg NA NA no no no no no no ErbB signaling pathway Chemical carcinogenesis - DNA adducts -0.64 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Chemical carcinogenesis - DNA adducts -0.494782609 0 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Chemical carcinogenesis - DNA adducts 0.626086957 0.518774704 0.85045045 yes kegg kegg NA NA no up up no no no Fatty acid degradation Chemical carcinogenesis - DNA adducts 0.595652174 0.496047431 0.426512227 kegg kegg NA NA no no no no no no Fatty acid elongation Chemical carcinogenesis - DNA adducts 0.540869565 0.490118577 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Chemical carcinogenesis - DNA adducts 0.643478261 0.579051383 0.446589447 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Chemical carcinogenesis - DNA adducts -0.496521739 0 0.438610039 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Chemical carcinogenesis - DNA adducts 0.524347826 0.561264822 0.463320463 kegg kegg NA NA no no no no no no Folate biosynthesis Chemical carcinogenesis - DNA adducts 0 -0.477272727 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Chemical carcinogenesis - DNA adducts 0.595652174 0 0.476447876 kegg kegg NA NA no no no no no no Galactose metabolism Chemical carcinogenesis - DNA adducts 0.567826087 0 0.432689833 kegg kegg NA NA no no no no no no Glucagon signaling pathway Chemical carcinogenesis - DNA adducts 0 -0.493083004 -0.641184041 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Chemical carcinogenesis - DNA adducts 0.682608696 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Chemical carcinogenesis - DNA adducts -0.873913043 -0.726284585 -0.508365508 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Chemical carcinogenesis - DNA adducts 0 0.434782609 0.465637066 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - globo and isoglobo series Chemical carcinogenesis - DNA adducts 0.412173913 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Chemical carcinogenesis - DNA adducts -0.673913043 0 0 kegg kegg NA NA no no no no no no GnRH secretion Chemical carcinogenesis - DNA adducts -0.629565217 0 0 kegg kegg NA NA no up up no no no GnRH signaling pathway Chemical carcinogenesis - DNA adducts -0.58 -0.553359684 -0.509137709 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Chemical carcinogenesis - DNA adducts -0.576521739 0 -0.408494208 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Chemical carcinogenesis - DNA adducts -0.651304348 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Chemical carcinogenesis - DNA adducts 0 0.454545455 0.471042471 kegg kegg NA NA no no no no no no Histidine metabolism Chemical carcinogenesis - DNA adducts 0.592173913 0.665019763 0.447361647 kegg kegg NA NA no no no no no no Homologous recombination Chemical carcinogenesis - DNA adducts 0 0 -0.442213642 kegg kegg NA NA no no no no no no Huntington disease Chemical carcinogenesis - DNA adducts -0.51826087 -0.507905138 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Chemical carcinogenesis - DNA adducts 0 0 0.552380952 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Chemical carcinogenesis - DNA adducts -0.537391304 -0.498023715 -0.638352638 kegg kegg NA NA no no no no no no Insulin resistance Chemical carcinogenesis - DNA adducts -0.406956522 0 0 kegg kegg NA NA no no no no no no Insulin secretion Chemical carcinogenesis - DNA adducts -0.712173913 -0.576086957 -0.476705277 yes kegg kegg NA NA no up up no no no Kaposi sarcoma-associated herpesvirus infection Chemical carcinogenesis - DNA adducts -0.480869565 0 0 kegg kegg NA NA no no dn no no no Legionellosis Chemical carcinogenesis - DNA adducts 0.542608696 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Chemical carcinogenesis - DNA adducts 0.565217391 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Chemical carcinogenesis - DNA adducts 0 0 0.442471042 kegg kegg NA NA no no no no no no Long-term depression Chemical carcinogenesis - DNA adducts -0.635652174 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Chemical carcinogenesis - DNA adducts -0.626956522 0 -0.466151866 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Chemical carcinogenesis - DNA adducts 0 0.514822134 0 kegg kegg NA NA no no no no no no Lysosome Chemical carcinogenesis - DNA adducts 0 0.423913043 0.724066924 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Chemical carcinogenesis - DNA adducts -0.852173913 -0.548418972 0 kegg kegg NA NA no no no no no no Melanogenesis Chemical carcinogenesis - DNA adducts -0.491304348 -0.488142292 -0.621621622 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Chemical carcinogenesis - DNA adducts 0.782608696 0 0.706306306 kegg kegg NA NA no no no no no no Mismatch repair Chemical carcinogenesis - DNA adducts 0.472173913 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Chemical carcinogenesis - DNA adducts -0.428695652 -0.433794466 0 kegg kegg NA NA no no no no no no Morphine addiction Chemical carcinogenesis - DNA adducts -0.54 0 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Chemical carcinogenesis - DNA adducts -0.593913043 -0.636363636 -0.507593308 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Chemical carcinogenesis - DNA adducts 0.593913043 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Chemical carcinogenesis - DNA adducts 0 0 -0.467181467 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Chemical carcinogenesis - DNA adducts 0.516521739 0.485177866 0.602316602 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Chemical carcinogenesis - DNA adducts -0.459130435 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Chemical carcinogenesis - DNA adducts 0.444347826 0.51284585 0.659202059 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Chemical carcinogenesis - DNA adducts 0.451304348 0 0.596396396 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Chemical carcinogenesis - DNA adducts 0.55826087 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Chemical carcinogenesis - DNA adducts -0.514782609 -0.508893281 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Chemical carcinogenesis - DNA adducts 0.52173913 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Chemical carcinogenesis - DNA adducts -0.552173913 0 0 kegg kegg NA NA no no no no no no Olfactory transduction Chemical carcinogenesis - DNA adducts 0.425217391 0.736166008 0.638352638 kegg kegg NA NA no no no no no no Oocyte meiosis Chemical carcinogenesis - DNA adducts 0 0 -0.474903475 kegg kegg NA NA no no no no no no Osteoclast differentiation Chemical carcinogenesis - DNA adducts 0 0 0.483655084 kegg kegg NA NA no no no no no no Other glycan degradation Chemical carcinogenesis - DNA adducts 0.440869565 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Chemical carcinogenesis - DNA adducts -0.437391304 -0.492094862 0 kegg kegg NA NA no no no no no no p53 signaling pathway Chemical carcinogenesis - DNA adducts 0 0 -0.519176319 kegg kegg NA NA no no no no no no Pancreatic secretion Chemical carcinogenesis - DNA adducts -0.622608696 0 -0.401544402 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Chemical carcinogenesis - DNA adducts 0 0.544466403 0.571171171 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Chemical carcinogenesis - DNA adducts -0.48 -0.460474308 -0.598198198 kegg kegg NA NA no no no no no no Parkinson disease Chemical carcinogenesis - DNA adducts -0.54173913 -0.464426877 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Chemical carcinogenesis - DNA adducts 0 0.434782609 0.593822394 kegg kegg NA NA no no no no no no Pathways in cancer Chemical carcinogenesis - DNA adducts -0.497391304 0 -0.554697555 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - DNA adducts -0.550434783 -0.47826087 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Chemical carcinogenesis - DNA adducts 0.508695652 0 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Chemical carcinogenesis - DNA adducts 0 0.497035573 0.641956242 kegg kegg NA NA no no no no no no Peroxisome Chemical carcinogenesis - DNA adducts 0.526086957 0.449604743 0 kegg kegg NA NA no no no no no no Pertussis Chemical carcinogenesis - DNA adducts 0.47826087 0.562252964 0.432947233 kegg kegg NA NA no no dn no no no Phagosome Chemical carcinogenesis - DNA adducts 0 0 0.541312741 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Chemical carcinogenesis - DNA adducts -0.583478261 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Chemical carcinogenesis - DNA adducts -0.576521739 0 0 kegg kegg NA NA no up up no no no Primary bile acid biosynthesis Chemical carcinogenesis - DNA adducts 0.567826087 0 0.442213642 kegg kegg NA NA no no no no no no Propanoate metabolism Chemical carcinogenesis - DNA adducts 0.609565217 0 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Chemical carcinogenesis - DNA adducts 0 0.420948617 0 yes kegg kegg NA NA no up up no no no Protein processing in endoplasmic reticulum Chemical carcinogenesis - DNA adducts 0 0 -0.558558559 kegg kegg NA NA no no no no no no Pyrimidine metabolism Chemical carcinogenesis - DNA adducts 0.7 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Chemical carcinogenesis - DNA adducts 0.512173913 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Chemical carcinogenesis - DNA adducts 0.425217391 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Chemical carcinogenesis - DNA adducts 0 0 -0.419047619 kegg kegg NA NA no no no no no no Relaxin signaling pathway Chemical carcinogenesis - DNA adducts -0.516521739 0 0 kegg kegg NA NA no no no no no no Renin secretion Chemical carcinogenesis - DNA adducts 0 0 -0.453796654 kegg kegg NA NA no no no no no no Renin-angiotensin system Chemical carcinogenesis - DNA adducts 0 0 0.419305019 kegg kegg NA NA no no no no no no Retinol metabolism Chemical carcinogenesis - DNA adducts 0.757391304 0 0 kegg kegg NA NA no no no no no no Ribosome Chemical carcinogenesis - DNA adducts -0.495652174 -0.420948617 0 kegg kegg NA NA no no no no no no RNA degradation Chemical carcinogenesis - DNA adducts -0.593913043 -0.486166008 0 kegg kegg NA NA no no no no no no Salmonella infection Chemical carcinogenesis - DNA adducts 0.614782609 0.581027668 0.486486486 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - DNA adducts -0.623478261 -0.623517787 -0.513513514 kegg kegg NA NA no no no no no no Sphingolipid metabolism Chemical carcinogenesis - DNA adducts 0 0 0.535907336 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Chemical carcinogenesis - DNA adducts 0 -0.53458498 0 kegg kegg NA NA no no no no no no Spliceosome Chemical carcinogenesis - DNA adducts 0 0 -0.47001287 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Chemical carcinogenesis - DNA adducts 0 0.515810277 0.506563707 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Chemical carcinogenesis - DNA adducts 0.647826087 0.420948617 0.614157014 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Chemical carcinogenesis - DNA adducts 0.734782609 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Chemical carcinogenesis - DNA adducts 0 0.633399209 0.648133848 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Chemical carcinogenesis - DNA adducts 0.406086957 0 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Chemical carcinogenesis - DNA adducts 0 0 -0.406177606 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Chemical carcinogenesis - DNA adducts -0.446956522 0 0 kegg kegg NA NA no no no no no no Thermogenesis Chemical carcinogenesis - DNA adducts -0.514782609 -0.488142292 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Chemical carcinogenesis - DNA adducts 0 -0.444664032 0 kegg kegg NA NA no no no no no no Toxoplasmosis Chemical carcinogenesis - DNA adducts 0.447826087 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Chemical carcinogenesis - DNA adducts 0.526956522 0 0 kegg kegg NA NA no up no no no no Tuberculosis Chemical carcinogenesis - DNA adducts 0 0.56916996 0.636550837 kegg kegg NA NA no no dn no no no Tyrosine metabolism Chemical carcinogenesis - DNA adducts 0.54173913 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Chemical carcinogenesis - DNA adducts 0.529565217 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Chemical carcinogenesis - DNA adducts -0.520869565 -0.434782609 -0.406949807 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Chemical carcinogenesis - DNA adducts 0.48 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Chemical carcinogenesis - DNA adducts -0.451304348 0 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Chemical carcinogenesis - DNA adducts -0.527826087 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Chemical carcinogenesis - DNA adducts -0.534782609 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Chemical carcinogenesis - DNA adducts -0.54173913 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Chemical carcinogenesis - DNA adducts -0.728695652 -0.497035573 0 kegg kegg NA NA no no no no no no Yersinia infection Chemical carcinogenesis - DNA adducts 0 0.492094862 0.401287001 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Chemical carcinogenesis - receptor activation -0.463478261 0 -0.480566281 kegg kegg NA NA no no no no no no ABC transporters Chemical carcinogenesis - receptor activation 0 0.482213439 0 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes Chemical carcinogenesis - receptor activation 0.650434783 0.416996047 0.647361647 kegg kegg NA NA no no up no no no Aldosterone synthesis and secretion Chemical carcinogenesis - receptor activation 0.693913043 0.597826087 0.715572716 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Chemical carcinogenesis - receptor activation -0.574782609 0 -0.522779923 kegg kegg NA NA no no no no no no Alzheimer disease Chemical carcinogenesis - receptor activation 0.51826087 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Chemical carcinogenesis - receptor activation 0.794782609 0.491106719 0.693436293 kegg kegg NA NA no no no no no no AMPK signaling pathway Chemical carcinogenesis - receptor activation 0 0.584980237 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Chemical carcinogenesis - receptor activation 0.534782609 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Chemical carcinogenesis - receptor activation 0 0.539525692 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Chemical carcinogenesis - receptor activation -0.608695652 -0.790513834 -0.502445302 kegg kegg NA NA no no no no no no Apoptosis - multiple species Chemical carcinogenesis - receptor activation 0 0.43083004 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Chemical carcinogenesis - receptor activation 0 -0.480237154 0 kegg kegg NA NA no no no no no no Base excision repair Chemical carcinogenesis - receptor activation 0 0.41798419 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Chemical carcinogenesis - receptor activation -0.536521739 0 -0.485971686 kegg kegg NA NA no no no no no no Bifidobacterium Chemical carcinogenesis - receptor activation 0 0 0.400271524 acetate-producing Genus kegg 0.105 NA no dn no no no no Bile secretion Chemical carcinogenesis - receptor activation 0.607826087 0.47826087 0.503732304 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Chemical carcinogenesis - receptor activation -0.620869565 -0.586956522 -0.503989704 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Chemical carcinogenesis - receptor activation 0 -0.424901186 0 kegg kegg NA NA no no no no no no Blautia Chemical carcinogenesis - receptor activation -0.462608696 0 0 acetate-producing Genus kegg 1.36E-05 NA up dn dn no no no Butanoate metabolism Chemical carcinogenesis - receptor activation -0.495652174 0 -0.42033462 kegg kegg NA NA no no no no no no Calcium signaling pathway Chemical carcinogenesis - receptor activation 0.535652174 0.435770751 0.645302445 kegg kegg NA NA no up up no no no cAMP signaling pathway Chemical carcinogenesis - receptor activation 0.666956522 0 0.665894466 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Chemical carcinogenesis - receptor activation 0 0.418972332 0 kegg kegg NA NA no no no no no no Carbon metabolism Chemical carcinogenesis - receptor activation -0.568695652 -0.745059289 -0.60978121 kegg kegg NA NA no no no no no no Cardiac muscle contraction Chemical carcinogenesis - receptor activation 0.514782609 0 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Chemical carcinogenesis - receptor activation -0.522608696 -0.678853755 0 kegg kegg NA NA no no no no no no Cell cycle Chemical carcinogenesis - receptor activation 0 0.457509881 0 kegg kegg NA NA no no no no no no Cellular senescence Chemical carcinogenesis - receptor activation -0.433043478 -0.441699605 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Chemical carcinogenesis - receptor activation 0 -0.43972332 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation -0.44 -0.425889328 -0.568082368 kegg kegg NA NA no no no no no no Cholesterol metabolism Chemical carcinogenesis - receptor activation 0 -0.687747036 0 yes kegg kegg NA NA no no up no no no Cholinergic synapse Chemical carcinogenesis - receptor activation 0.497391304 0 0 kegg kegg NA NA no no no no no no Circadian entrainment Chemical carcinogenesis - receptor activation 0.552173913 0 0.535135135 kegg kegg NA NA no up up no no no Circadian rhythm Chemical carcinogenesis - receptor activation 0.466086957 0.68083004 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Chemical carcinogenesis - receptor activation 0 0 -0.462805663 kegg kegg NA NA no no no no no no Clostridium Chemical carcinogenesis - receptor activation -0.422567302 -0.514496764 0 Genus kegg 0.925 NA no no no no no no Cocaine addiction Chemical carcinogenesis - receptor activation 0.595652174 0.785573123 0.675160875 kegg kegg NA NA no no no no no no Complement and coagulation cascades Chemical carcinogenesis - receptor activation -0.509565217 -0.482213439 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Chemical carcinogenesis - receptor activation 0.685217391 0.864624506 0.778378378 kegg kegg NA NA no no up no no no Cushing syndrome Chemical carcinogenesis - receptor activation 0.742608696 0.863636364 0.803603604 kegg kegg NA NA no no up no no no Dopaminergic synapse Chemical carcinogenesis - receptor activation 0.726956522 0 0.717374517 kegg kegg NA NA no up no no no no Dorea Chemical carcinogenesis - receptor activation -0.44 0 0 Genus kegg 0.00362 NA up no dn no no no Drug metabolism - cytochrome P450 Chemical carcinogenesis - receptor activation 0 0 -0.525353925 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Chemical carcinogenesis - receptor activation -0.593913043 0 -0.474131274 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Chemical carcinogenesis - receptor activation 0.565217391 0.470355731 0.664092664 kegg kegg NA NA no no no no no no Endocrine resistance Chemical carcinogenesis - receptor activation 0.807826087 0.882411067 0.867953668 kegg kegg NA NA no no no no no no Endocytosis Chemical carcinogenesis - receptor activation -0.483478261 -0.650197628 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Chemical carcinogenesis - receptor activation -0.533913043 -0.734189723 -0.425225225 kegg kegg NA NA no no no no no no ErbB signaling pathway Chemical carcinogenesis - receptor activation 0 0.485177866 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Chemical carcinogenesis - receptor activation 0.446086957 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Chemical carcinogenesis - receptor activation 0.420869565 0.451581028 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Chemical carcinogenesis - receptor activation 0 0.469367589 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Chemical carcinogenesis - receptor activation 0 0 -0.52972973 yes kegg kegg NA NA no up up no no no Fatty acid degradation Chemical carcinogenesis - receptor activation -0.487826087 0 -0.622651223 kegg kegg NA NA no no no no no no Fatty acid elongation Chemical carcinogenesis - receptor activation -0.456521739 -0.609683794 -0.436293436 kegg kegg NA NA no no no no no no Fatty acid metabolism Chemical carcinogenesis - receptor activation -0.582608696 0 -0.61003861 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Chemical carcinogenesis - receptor activation -0.415652174 -0.598814229 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Chemical carcinogenesis - receptor activation -0.452173913 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Chemical carcinogenesis - receptor activation -0.472173913 0 0 kegg kegg NA NA no no no no no no Gap junction Chemical carcinogenesis - receptor activation 0.466086957 0.545454545 0.439382239 kegg kegg NA NA no no no no no no Glucagon signaling pathway Chemical carcinogenesis - receptor activation 0.691304348 0.501976285 0.561647362 kegg kegg NA NA no no no no no no Glutamatergic synapse Chemical carcinogenesis - receptor activation 0.424347826 0.432806324 0.434491634 kegg kegg NA NA no up up no no no Glycerophospholipid metabolism Chemical carcinogenesis - receptor activation 0 0.638339921 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Chemical carcinogenesis - receptor activation -0.426956522 -0.490118577 -0.473873874 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Chemical carcinogenesis - receptor activation 0 -0.503952569 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Chemical carcinogenesis - receptor activation 0 0.545454545 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Chemical carcinogenesis - receptor activation -0.565217391 0 0 kegg kegg NA NA no no no no no no GnRH secretion Chemical carcinogenesis - receptor activation 0.413913043 0.529644269 0 kegg kegg NA NA no up up no no no GnRH signaling pathway Chemical carcinogenesis - receptor activation 0.657391304 0.742094862 0.693178893 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Chemical carcinogenesis - receptor activation 0.693913043 0.764822134 0.807464607 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Chemical carcinogenesis - receptor activation 0.529565217 0.510869565 0 kegg kegg NA NA no no no no no no Hepatitis C Chemical carcinogenesis - receptor activation 0 0 0.427284427 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Chemical carcinogenesis - receptor activation -0.545217391 -0.704545455 -0.44015444 kegg kegg NA NA no no no no no no Histidine metabolism Chemical carcinogenesis - receptor activation 0 0 -0.403861004 kegg kegg NA NA no no no no no no Homologous recombination Chemical carcinogenesis - receptor activation 0 0.435770751 0 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Chemical carcinogenesis - receptor activation -0.435652174 -0.687747036 0 kegg kegg NA NA no no dn no no no Human immunodeficiency virus 1 infection Chemical carcinogenesis - receptor activation -0.423478261 -0.703557312 -0.442213642 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Chemical carcinogenesis - receptor activation -0.573043478 -0.725296443 -0.408494208 kegg kegg NA NA no no no no no no Huntington disease Chemical carcinogenesis - receptor activation 0.474782609 0 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Chemical carcinogenesis - receptor activation 0 -0.488142292 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Chemical carcinogenesis - receptor activation 0.611304348 0 0.689317889 kegg kegg NA NA no no no no no no Influenza A Chemical carcinogenesis - receptor activation 0 -0.568181818 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Chemical carcinogenesis - receptor activation 0 0.5256917 0 kegg kegg NA NA no no no no no no Insulin secretion Chemical carcinogenesis - receptor activation 0.61826087 0.795454545 0.767567568 yes kegg kegg NA NA no up up no no no Leishmaniasis Chemical carcinogenesis - receptor activation -0.582608696 -0.481225296 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Chemical carcinogenesis - receptor activation 0 -0.558300395 0 kegg kegg NA NA no no no no no no Long-term depression Chemical carcinogenesis - receptor activation 0.583478261 0.437747036 0.645045045 kegg kegg NA NA no no no no no no Long-term potentiation Chemical carcinogenesis - receptor activation 0.436521739 0 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Chemical carcinogenesis - receptor activation 0 0.471343874 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Chemical carcinogenesis - receptor activation 0 -0.598814229 0 kegg kegg NA NA no no no no no no Lysine degradation Chemical carcinogenesis - receptor activation 0 0.672924901 0 kegg kegg NA NA no no no no no no Lysosome Chemical carcinogenesis - receptor activation 0 -0.68972332 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Chemical carcinogenesis - receptor activation 0 0.563241107 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Chemical carcinogenesis - receptor activation 0 0.448616601 0 kegg kegg NA NA no up no no no no Melanogenesis Chemical carcinogenesis - receptor activation 0.611304348 0 0.696010296 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Chemical carcinogenesis - receptor activation -0.413043478 0 -0.554697555 kegg kegg NA NA no no no no no no Morphine addiction Chemical carcinogenesis - receptor activation 0.592173913 0.586956522 0.633976834 kegg kegg NA NA no up up no no no mRNA surveillance pathway Chemical carcinogenesis - receptor activation 0.52173913 0.467391304 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Chemical carcinogenesis - receptor activation -0.497391304 -0.555335968 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Chemical carcinogenesis - receptor activation 0 -0.714426877 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Chemical carcinogenesis - receptor activation -0.51826087 -0.564229249 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Chemical carcinogenesis - receptor activation -0.466086957 0 0 kegg kegg NA NA no no no no no no Nicotine addiction Chemical carcinogenesis - receptor activation 0 0.623517787 0 kegg kegg NA NA no up up no no no Non-alcoholic fatty liver disease Chemical carcinogenesis - receptor activation 0.571304348 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Chemical carcinogenesis - receptor activation 0 -0.424901186 -0.403346203 kegg kegg NA NA no no no no no no Notch signaling pathway Chemical carcinogenesis - receptor activation 0 0.700592885 0 kegg kegg NA NA no no no no no no Odoribacter Chemical carcinogenesis - receptor activation 0 -0.57503891 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Olfactory transduction Chemical carcinogenesis - receptor activation 0 -0.501976285 -0.43963964 kegg kegg NA NA no no no no no no Osteoclast differentiation Chemical carcinogenesis - receptor activation -0.406086957 0 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Chemical carcinogenesis - receptor activation 0 0.778656126 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Chemical carcinogenesis - receptor activation 0.620869565 0.611660079 0.509137709 kegg kegg NA NA no up up no no no Oxidative phosphorylation Chemical carcinogenesis - receptor activation 0.459130435 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Chemical carcinogenesis - receptor activation 0 0.556324111 0 kegg kegg NA NA no no no no no no Pancreatic secretion Chemical carcinogenesis - receptor activation 0.600869565 0 0.71042471 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Chemical carcinogenesis - receptor activation 0 0 -0.491891892 kegg kegg NA NA no no dn no no no Paraprevotella Chemical carcinogenesis - receptor activation -0.416995205 0 0 Genus kegg 0.118 NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Chemical carcinogenesis - receptor activation 0.680869565 0 0.651994852 kegg kegg NA NA no no no no no no Parkinson disease Chemical carcinogenesis - receptor activation 0.509565217 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Chemical carcinogenesis - receptor activation 0 -0.668972332 0 kegg kegg NA NA no no no no no no Pathways in cancer Chemical carcinogenesis - receptor activation 0.560869565 0 0.52998713 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - receptor activation 0.503478261 0 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Chemical carcinogenesis - receptor activation -0.456521739 -0.588932806 0 kegg kegg NA NA no no no no no no Peroxisome Chemical carcinogenesis - receptor activation -0.584347826 0 0 kegg kegg NA NA no no no no no no Pertussis Chemical carcinogenesis - receptor activation 0 -0.618577075 0 kegg kegg NA NA no no dn no no no Phagosome Chemical carcinogenesis - receptor activation -0.545217391 -0.690711462 -0.413127413 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Chemical carcinogenesis - receptor activation 0.490434783 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Chemical carcinogenesis - receptor activation 0 0 0.500900901 kegg kegg NA NA no up up no no no Phototransduction Chemical carcinogenesis - receptor activation 0 -0.505928854 0 kegg kegg NA NA no no no no no no Platinum drug resistance Chemical carcinogenesis - receptor activation 0 0.505928854 0 kegg kegg NA NA no no no no no no Prevotella Chemical carcinogenesis - receptor activation 0 0 0.458451614 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Chemical carcinogenesis - receptor activation 0 -0.4743083 0 kegg kegg NA NA no no no no no no Prion disease Chemical carcinogenesis - receptor activation 0.484347826 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Chemical carcinogenesis - receptor activation 0 0.5 0 kegg kegg NA NA no no no no no no Proteasome Chemical carcinogenesis - receptor activation 0 -0.504940711 -0.572972973 kegg kegg NA NA no no no no no no Protein digestion and absorption Chemical carcinogenesis - receptor activation -0.526956522 0 0 yes kegg kegg NA NA no up up no no no Purine metabolism Chemical carcinogenesis - receptor activation 0 0.494071146 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Chemical carcinogenesis - receptor activation -0.486086957 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Chemical carcinogenesis - receptor activation 0 -0.4743083 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Chemical carcinogenesis - receptor activation 0.688695652 0.641304348 0.655341055 kegg kegg NA NA no no no no no no Relaxin signaling pathway Chemical carcinogenesis - receptor activation 0.540869565 0 0.654826255 kegg kegg NA NA no no no no no no Renin secretion Chemical carcinogenesis - receptor activation 0.448695652 0 0.52972973 kegg kegg NA NA no no no no no no Renin-angiotensin system Chemical carcinogenesis - receptor activation 0 -0.588932806 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Chemical carcinogenesis - receptor activation 0 0.427865613 0 kegg kegg NA NA no no no no no no RNA degradation Chemical carcinogenesis - receptor activation 0.425217391 0 0 kegg kegg NA NA no no no no no no Salivary secretion Chemical carcinogenesis - receptor activation 0 0 0.422908623 kegg kegg NA NA no no no no no no Salmonella infection Chemical carcinogenesis - receptor activation 0 -0.828063241 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Chemical carcinogenesis - receptor activation 0 0.564229249 0 kegg kegg NA NA no no no no no no Serotonergic synapse Chemical carcinogenesis - receptor activation 0.585217391 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - receptor activation 0.586956522 0.683794466 0 kegg kegg NA NA no no no no no no Spliceosome Chemical carcinogenesis - receptor activation 0 0.495059289 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Chemical carcinogenesis - receptor activation -0.645217391 -0.73715415 0 kegg kegg NA NA up no no no no no Steroid biosynthesis Chemical carcinogenesis - receptor activation 0.433913043 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Chemical carcinogenesis - receptor activation 0 -0.536561265 0 kegg kegg NA NA no up up no no no Taurine and hypotaurine metabolism Chemical carcinogenesis - receptor activation 0 0.703557312 0 kegg kegg NA NA no no no no no no Thermogenesis Chemical carcinogenesis - receptor activation 0.50173913 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Chemical carcinogenesis - receptor activation 0 0.651185771 0.418275418 kegg kegg NA NA no no no no no no Tight junction Chemical carcinogenesis - receptor activation 0 -0.4743083 0 kegg kegg NA NA no no no no no no Toxoplasmosis Chemical carcinogenesis - receptor activation 0 -0.53458498 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Chemical carcinogenesis - receptor activation -0.471304348 0 -0.458172458 kegg kegg NA NA no up no no no no Tuberculosis Chemical carcinogenesis - receptor activation -0.624347826 -0.694664032 -0.403603604 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Chemical carcinogenesis - receptor activation -0.535652174 -0.583003953 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Chemical carcinogenesis - receptor activation 0 0.447628458 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Chemical carcinogenesis - receptor activation 0.43826087 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Chemical carcinogenesis - receptor activation 0.48 0 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Chemical carcinogenesis - receptor activation 0.711304348 0.421936759 0.60952381 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Chemical carcinogenesis - receptor activation 0.448695652 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Chemical carcinogenesis - receptor activation 0.425217391 0 0 kegg kegg NA NA no no no no no no Yersinia infection Chemical carcinogenesis - receptor activation 0 -0.635375494 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Chemokine signaling pathway 0 -0.652173913 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Chemokine signaling pathway 0 0.60770751 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Chemokine signaling pathway 0 -0.431818182 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Chemokine signaling pathway -0.526956522 -0.747035573 -0.548262548 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Chemokine signaling pathway -0.406956522 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Chemokine signaling pathway 0 0.706521739 0.433976834 kegg kegg NA NA no up no no no no Arginine biosynthesis Chemokine signaling pathway 0 0.674901186 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Chemokine signaling pathway 0 -0.514822134 -0.455083655 kegg kegg NA NA no no no no no no Basal transcription factors Chemokine signaling pathway 0 -0.790513834 -0.690862291 kegg kegg NA NA no no no no no no Base excision repair Chemokine signaling pathway -0.513043478 -0.59486166 -0.701930502 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Chemokine signaling pathway 0 0.663043478 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Chemokine signaling pathway -0.555652174 -0.617588933 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Chemokine signaling pathway -0.447826087 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Chemokine signaling pathway -0.500869565 -0.651185771 -0.597683398 kegg kegg NA NA no no no no no no cAMP signaling pathway Chemokine signaling pathway 0.433043478 0.5 0 yes kegg kegg NA NA no up up no no no cGMP-PKG signaling pathway Chemokine signaling pathway 0 0.761857708 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Chemokine signaling pathway -0.58 -0.671936759 -0.5001287 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Chemokine signaling pathway -0.433913043 -0.565217391 -0.592792793 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Chemokine signaling pathway 0.700869565 0.509881423 0.46023166 kegg kegg NA NA no no no no no no DNA replication Chemokine signaling pathway -0.606956522 -0.769762846 -0.505276705 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Chemokine signaling pathway 0 -0.646245059 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Chemokine signaling pathway 0 -0.526679842 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway 0 0 -0.476962677 kegg kegg NA NA no no no no no no Ether lipid metabolism Chemokine signaling pathway 0 -0.735177866 -0.523809524 kegg kegg NA NA no no no no no no Fanconi anemia pathway Chemokine signaling pathway -0.544347826 -0.739130435 -0.655855856 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Chemokine signaling pathway 0 0.650197628 0 kegg kegg NA NA no no no no no no Folate biosynthesis Chemokine signaling pathway 0 -0.501976285 0 kegg kegg NA NA no no no no no no Glutathione metabolism Chemokine signaling pathway -0.443478261 0 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Chemokine signaling pathway 0 0 -0.491634492 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Chemokine signaling pathway -0.465217391 -0.462450593 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Chemokine signaling pathway 0 0.463438735 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Chemokine signaling pathway 0 -0.427865613 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Chemokine signaling pathway 0.495652174 0 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Chemokine signaling pathway 0 -0.68972332 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Chemokine signaling pathway 0 -0.557312253 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Chemokine signaling pathway 0 0.688735178 0 kegg kegg NA NA no no no no no no Histidine metabolism Chemokine signaling pathway -0.436521739 0 0 kegg kegg NA NA no no no no no no Homologous recombination Chemokine signaling pathway -0.41826087 -0.542490119 -0.714285714 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Chemokine signaling pathway 0 0 -0.516087516 kegg kegg NA NA no no no no no no Lysine degradation Chemokine signaling pathway 0 -0.522727273 -0.50990991 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Chemokine signaling pathway 0 0 -0.414671815 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Chemokine signaling pathway 0 -0.605731225 0 kegg kegg NA NA no no no no no no Mismatch repair Chemokine signaling pathway -0.493043478 -0.592885375 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Chemokine signaling pathway 0 -0.717391304 -0.486229086 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Chemokine signaling pathway -0.427826087 -0.732213439 -0.44041184 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Chemokine signaling pathway 0 0.692687747 0.412612613 kegg kegg NA NA no no no no no no Nitrogen metabolism Chemokine signaling pathway 0 0.719367589 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Chemokine signaling pathway 0 0 -0.419047619 kegg kegg NA NA no no no no no no Nucleotide excision repair Chemokine signaling pathway -0.627826087 -0.734189723 -0.637065637 kegg kegg NA NA no no no no no no One carbon pool by folate Chemokine signaling pathway -0.663478261 -0.739130435 -0.603088803 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Chemokine signaling pathway 0 -0.506916996 -0.615444015 kegg kegg NA NA no no no no no no Oxidative phosphorylation Chemokine signaling pathway 0 -0.429841897 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Chemokine signaling pathway 0 0.542490119 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Chemokine signaling pathway 0 -0.777667984 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Chemokine signaling pathway 0 0.705533597 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Chemokine signaling pathway 0 -0.491106719 0 kegg kegg NA NA no no no no no no Platinum drug resistance Chemokine signaling pathway 0 0 -0.610553411 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Chemokine signaling pathway -0.440869565 -0.434782609 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Chemokine signaling pathway 0 0.584980237 0.569111969 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Chemokine signaling pathway -0.626086957 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Chemokine signaling pathway -0.451304348 -0.496047431 -0.607722008 kegg kegg NA NA no no no no no no Proteasome Chemokine signaling pathway 0 -0.56027668 0 kegg kegg NA NA no no no no no no Protein export Chemokine signaling pathway 0 -0.62944664 -0.452509653 kegg kegg NA NA no no no no no no Purine metabolism Chemokine signaling pathway -0.425217391 -0.470355731 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Chemokine signaling pathway -0.532173913 -0.58201581 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Chemokine signaling pathway -0.593913043 -0.625494071 -0.644015444 kegg kegg NA NA no no no no no no Rap1 signaling pathway Chemokine signaling pathway 0 0 0.572200772 kegg kegg NA NA no no no no no no Ras signaling pathway Chemokine signaling pathway 0 -0.449604743 0 yes kegg kegg NA NA no up up no no no Retinol metabolism Chemokine signaling pathway 0 -0.479249012 -0.507593308 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Chemokine signaling pathway -0.493043478 -0.804347826 -0.642985843 kegg kegg NA NA no no no no no no RNA degradation Chemokine signaling pathway 0 -0.706521739 -0.4998713 kegg kegg NA NA no no no no no no RNA polymerase Chemokine signaling pathway 0 -0.838932806 -0.60952381 kegg kegg NA NA no no no no no no RNA transport Chemokine signaling pathway 0 0 -0.438867439 kegg kegg NA NA no no no no no no Selenocompound metabolism Chemokine signaling pathway -0.43826087 -0.549407115 -0.676190476 kegg kegg NA NA no no no no no no Spliceosome Chemokine signaling pathway 0 -0.433794466 -0.620592021 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Chemokine signaling pathway 0 0.466403162 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Chemokine signaling pathway 0 -0.617588933 -0.474131274 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Chemokine signaling pathway -0.444347826 -0.524703557 0 kegg kegg NA NA no no no no no no Sulfur metabolism Chemokine signaling pathway -0.499130435 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Chemokine signaling pathway -0.605217391 -0.727272727 -0.558043758 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Chemokine signaling pathway 0 -0.697628458 -0.442985843 kegg kegg NA NA no no no no no no Thiamine metabolism Chemokine signaling pathway 0 -0.46541502 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Chemokine signaling pathway -0.560869565 -0.502964427 -0.555469755 kegg kegg NA NA no up no no no no Tyrosine metabolism Chemokine signaling pathway -0.443478261 -0.564229249 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Chemokine signaling pathway -0.656521739 -0.650197628 -0.522779923 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Chemokine signaling pathway -0.673913043 -0.75 -0.58970399 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Chemokine signaling pathway 0 -0.674901186 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway 0.774782609 0.718379447 0.68005148 kegg kegg NA NA no no no no no no ABC transporters Cholesterol metabolism 0 -0.549407115 0 yes kegg kegg NA NA no up up no no up Adipocytokine signaling pathway Cholesterol metabolism 0.539130435 0 0 yes kegg kegg NA NA no no no no no up Aldosterone synthesis and secretion Cholesterol metabolism 0 -0.57312253 -0.473873874 yes kegg kegg NA NA no up up no no up Aminoacyl-tRNA biosynthesis Cholesterol metabolism -0.517391304 0 -0.420592021 yes kegg kegg NA NA no no no no no up AMPK signaling pathway Cholesterol metabolism 0 -0.499011858 -0.420849421 yes kegg kegg NA NA no no no no no up Antifolate resistance Cholesterol metabolism -0.557391304 -0.567193676 0 yes kegg kegg NA NA no no no no no up Antigen processing and presentation Cholesterol metabolism 0.506086957 0.593873518 0 yes kegg kegg NA NA no no no no no up Apoptosis Cholesterol metabolism 0 0.578063241 0.420592021 yes kegg kegg NA NA no no no no no up Apoptosis - multiple species Cholesterol metabolism -0.466086957 -0.541501976 0 yes kegg kegg NA NA no no no no no up Arginine and proline metabolism Cholesterol metabolism 0 0 0.463577864 yes kegg kegg NA NA no up no no no up Axon guidance Cholesterol metabolism 0 0.415019763 0 yes kegg kegg NA NA no up up no no up B cell receptor signaling pathway Cholesterol metabolism 0 0.425889328 0.607979408 yes kegg kegg NA NA no no no no no up Basal transcription factors Cholesterol metabolism 0 -0.546442688 0 yes kegg kegg NA NA no no no no no up Base excision repair Cholesterol metabolism -0.446956522 -0.652173913 0 yes kegg kegg NA NA no no no no no up Bile secretion Cholesterol metabolism 0 0 -0.422908623 yes kegg kegg NA NA no no no no no up Biosynthesis of amino acids Cholesterol metabolism 0 0.606719368 0.415958816 yes kegg kegg NA NA no no no no no up Biosynthesis of cofactors Cholesterol metabolism 0 -0.666007905 0 yes kegg kegg NA NA no no no no no up C-type lectin receptor signaling pathway Cholesterol metabolism 0 0.41798419 0.482625483 yes kegg kegg NA NA no no no no no up Carbon metabolism Cholesterol metabolism 0 0.664031621 0.442985843 yes kegg kegg NA NA no no no no no up Cell adhesion molecules Cholesterol metabolism 0 0.729249012 0 yes kegg kegg NA NA no no no no no up Cell cycle Cholesterol metabolism -0.507826087 -0.650197628 -0.40978121 yes kegg kegg NA NA no no no no no up Cellular senescence Cholesterol metabolism 0 0.553359684 0 yes kegg kegg NA NA no no no no no up cGMP-PKG signaling pathway Cholesterol metabolism 0 0.545454545 0.707593308 yes kegg kegg NA NA no no no no no up Circadian entrainment Cholesterol metabolism 0 0 -0.422651223 yes kegg kegg NA NA no up up no no up Circadian rhythm Cholesterol metabolism 0 -0.565217391 0 yes kegg kegg NA NA no no no no no up Complement and coagulation cascades Cholesterol metabolism 0 0.458498024 0 yes kegg kegg NA NA no no no no no up Cortisol synthesis and secretion Cholesterol metabolism 0 -0.608695652 -0.404890605 yes kegg kegg NA NA no no up no no up Cushing syndrome Cholesterol metabolism 0 -0.674901186 0 yes kegg kegg NA NA no no up no no up Cysteine and methionine metabolism Cholesterol metabolism 0 0 -0.435006435 yes kegg kegg NA NA no no no no no up DNA replication Cholesterol metabolism -0.448695652 0 0 yes kegg kegg NA NA no no no no no up Dopaminergic synapse Cholesterol metabolism 0 -0.437747036 0 yes kegg kegg NA NA no up no no no up Drug metabolism - other enzymes Cholesterol metabolism 0 0 0.404890605 yes kegg kegg NA NA no no no no no up Endocrine and other factor-regulated calcium reabsorption Cholesterol metabolism 0 -0.477272727 -0.559330759 yes kegg kegg NA NA no no no no no up Endocrine resistance Cholesterol metabolism 0 -0.650197628 -0.473101673 yes kegg kegg NA NA no no no no no up Endocytosis Cholesterol metabolism 0 0.646245059 0 yes kegg kegg NA NA no no no no no up Estrogen signaling pathway Cholesterol metabolism -0.512173913 0 -0.653024453 yes kegg kegg NA NA no no no no no up Ether lipid metabolism Cholesterol metabolism 0 -0.564229249 0 yes kegg kegg NA NA no no no no no up Fanconi anemia pathway Cholesterol metabolism -0.592173913 -0.595849802 0 yes kegg kegg NA NA no no no no no up Fat digestion and absorption Cholesterol metabolism 0 0 0.647361647 yes yes kegg kegg NA NA no up up no no up Fc epsilon RI signaling pathway Cholesterol metabolism 0 0 0.583268983 yes kegg kegg NA NA no no no no no up Fc gamma R-mediated phagocytosis Cholesterol metabolism 0 0.448616601 0 yes kegg kegg NA NA no no no no no up FoxO signaling pathway Cholesterol metabolism -0.549565217 0 0 yes kegg kegg NA NA no no no no no up Fructose and mannose metabolism Cholesterol metabolism 0 0 0.404118404 yes kegg kegg NA NA no no no no no up Gap junction Cholesterol metabolism 0 0 -0.422651223 yes kegg kegg NA NA no no no no no up Glucagon signaling pathway Cholesterol metabolism 0 -0.56027668 -0.476962677 yes kegg kegg NA NA no no no no no up Glycerophospholipid metabolism Cholesterol metabolism 0 -0.558300395 0 yes kegg kegg NA NA no no up no no up "Glycine, serine and threonine metabolism" Cholesterol metabolism 0 -0.657114625 0 yes kegg kegg NA NA no up no no no up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Cholesterol metabolism 0 0 0.43989704 yes kegg kegg NA NA no no no no no up Glycosaminoglycan degradation Cholesterol metabolism 0.69826087 0.588932806 0.527927928 yes kegg kegg NA NA no no up no no up Glycosphingolipid biosynthesis - globo and isoglobo series Cholesterol metabolism 0.506956522 0 0 yes kegg kegg NA NA no no no no no up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Cholesterol metabolism -0.640869565 -0.650197628 0 yes kegg kegg NA NA no no no no no up Glyoxylate and dicarboxylate metabolism Cholesterol metabolism 0 0 0.43037323 yes kegg kegg NA NA no no no no no up GnRH signaling pathway Cholesterol metabolism 0 -0.513833992 0 yes kegg kegg NA NA no no no no no up "Growth hormone synthesis, secretion and action" Cholesterol metabolism 0 -0.489130435 0 yes kegg kegg NA NA no no no no no up Hedgehog signaling pathway Cholesterol metabolism 0 -0.570158103 0 yes kegg kegg NA NA no no no no no up Hippo signaling pathway - multiple species Cholesterol metabolism 0 0 0.622908623 yes kegg kegg NA NA no no no no no up Homologous recombination Cholesterol metabolism -0.633043478 -0.550395257 0 yes kegg kegg NA NA no no no no no up IL-17 signaling pathway Cholesterol metabolism 0 0.62944664 0.612355212 yes kegg kegg NA NA no no no no no up Inflammatory mediator regulation of TRP channels Cholesterol metabolism 0 -0.4743083 -0.65971686 yes kegg kegg NA NA no no no no no up Inositol phosphate metabolism Cholesterol metabolism -0.596521739 -0.460474308 0 yes kegg kegg NA NA no no no no no up Insulin secretion Cholesterol metabolism 0 -0.603754941 0 yes yes kegg kegg NA NA no up up no no up Intestinal immune network for IgA production Cholesterol metabolism 0 0.504940711 0 yes kegg kegg NA NA no no no no no up JAK-STAT signaling pathway Cholesterol metabolism -0.583478261 0 0 yes kegg kegg NA NA no no no no no up Leukocyte transendothelial migration Cholesterol metabolism 0 0.564229249 0 yes kegg kegg NA NA no no no no no up Long-term depression Cholesterol metabolism 0 0 -0.406177606 yes kegg kegg NA NA no no no no no up Longevity regulating pathway Cholesterol metabolism 0 -0.509881423 0 yes kegg kegg NA NA no no no no no up Longevity regulating pathway - multiple species Cholesterol metabolism -0.48173913 0 0 yes kegg kegg NA NA no no no no no up Lysine degradation Cholesterol metabolism 0 -0.509881423 0 yes kegg kegg NA NA no no no no no up Lysosome Cholesterol metabolism 0.570434783 0.735177866 0.721750322 yes kegg kegg NA NA no no no no no up MAPK signaling pathway Cholesterol metabolism -0.462608696 0 0 yes kegg kegg NA NA no no no no no up Melanogenesis Cholesterol metabolism 0 -0.423913043 -0.569111969 yes kegg kegg NA NA no no no no no up N-Glycan biosynthesis Cholesterol metabolism -0.412173913 0 -0.431402831 yes kegg kegg NA NA no no no no no up Natural killer cell mediated cytotoxicity Cholesterol metabolism 0 0.614624506 0 yes kegg kegg NA NA no no no no no up Neuroactive ligand-receptor interaction Cholesterol metabolism 0 0.517786561 0.533848134 yes kegg kegg NA NA up up up no no up Neurotrophin signaling pathway Cholesterol metabolism 0 0.440711462 0.498069498 yes kegg kegg NA NA no no no no no up Neutrophil extracellular trap formation Cholesterol metabolism 0 0.460474308 0 yes kegg kegg NA NA no no no no no up Nicotinate and nicotinamide metabolism Cholesterol metabolism 0 0 0.594079794 yes kegg kegg NA NA no no no no no up NOD-like receptor signaling pathway Cholesterol metabolism 0 0.416007905 0 yes kegg kegg NA NA no no no no no up Nucleotide excision repair Cholesterol metabolism -0.468695652 -0.510869565 0 yes kegg kegg NA NA no no no no no up Olfactory transduction Cholesterol metabolism 0 0 0.564221364 yes kegg kegg NA NA no no no no no up One carbon pool by folate Cholesterol metabolism -0.693043478 -0.566205534 0 yes kegg kegg NA NA no no no no no up Osteoclast differentiation Cholesterol metabolism 0 0.467391304 0.552380952 yes kegg kegg NA NA no no no no no up Other types of O-glycan biosynthesis Cholesterol metabolism 0 -0.722332016 0 yes kegg kegg NA NA no no no no no up Ovarian steroidogenesis Cholesterol metabolism 0 -0.529644269 -0.463835264 yes kegg kegg NA NA no up up no no up p53 signaling pathway Cholesterol metabolism 0 -0.681818182 0 yes kegg kegg NA NA no no no no no up Pancreatic secretion Cholesterol metabolism 0 0 -0.46023166 yes kegg kegg NA NA no no no no no up Pantothenate and CoA biosynthesis Cholesterol metabolism 0 0 0.527413127 yes kegg kegg NA NA no no dn no no up Pentose phosphate pathway Cholesterol metabolism 0 0.583992095 0.534877735 yes kegg kegg NA NA no no no no no up Phagosome Cholesterol metabolism 0 0.721343874 0 yes kegg kegg NA NA no no no no no up Phosphatidylinositol signaling system Cholesterol metabolism 0 -0.658102767 0 yes kegg kegg NA NA no no no no no up Platinum drug resistance Cholesterol metabolism -0.54173913 -0.583003953 0 yes kegg kegg NA NA no no no no no up Porphyrin and chlorophyll metabolism Cholesterol metabolism 0 -0.510869565 0 yes kegg kegg NA NA no no no no no up PPAR signaling pathway Cholesterol metabolism 0.406086957 0.556324111 0.512226512 yes kegg kegg NA NA no no no no no up Progesterone-mediated oocyte maturation Cholesterol metabolism 0 -0.503952569 0 yes kegg kegg NA NA no no no no no up Protein processing in endoplasmic reticulum Cholesterol metabolism 0 0 -0.465122265 yes kegg kegg NA NA no no no no no up Purine metabolism Cholesterol metabolism 0 -0.656126482 0 yes kegg kegg NA NA no no no no no up Pyrimidine metabolism Cholesterol metabolism 0 -0.495059289 0 yes kegg kegg NA NA no no no no no up Pyruvate metabolism Cholesterol metabolism -0.454782609 0 0 yes kegg kegg NA NA no no no no no up Regulation of lipolysis in adipocytes Cholesterol metabolism 0 -0.536561265 -0.555727156 yes kegg kegg NA NA no no no no no up Renin secretion Cholesterol metabolism 0 0 -0.560875161 yes kegg kegg NA NA no no no no no up Renin-angiotensin system Cholesterol metabolism 0 0.591897233 0.553925354 yes kegg kegg NA NA no no no no no up Retinol metabolism Cholesterol metabolism 0 -0.41798419 0 yes kegg kegg NA NA no no no no no up Ribosome biogenesis in eukaryotes Cholesterol metabolism -0.544347826 -0.56916996 0 yes kegg kegg NA NA no no no no no up RNA polymerase Cholesterol metabolism 0 -0.539525692 0 yes kegg kegg NA NA no no no no no up Selenocompound metabolism Cholesterol metabolism 0 -0.593873518 0 yes kegg kegg NA NA no no no no no up Sphingolipid metabolism Cholesterol metabolism 0.653043478 0 0.593307593 yes kegg kegg NA NA no no no no no up Sphingolipid signaling pathway Cholesterol metabolism 0 0.542490119 0 yes kegg kegg NA NA no no no no no up Spliceosome Cholesterol metabolism 0 -0.537549407 0 yes kegg kegg NA NA no no no no no up Starch and sucrose metabolism Cholesterol metabolism 0 0 0.591505792 yes kegg kegg NA NA no no no no no up Synaptic vesicle cycle Cholesterol metabolism 0 0.485177866 0.62007722 yes kegg kegg NA NA no up up no no up Synthesis and degradation of ketone bodies Cholesterol metabolism -0.533913043 -0.462450593 0 yes kegg kegg NA NA no no no no no up Taste transduction Cholesterol metabolism -0.529565217 -0.555335968 0 yes kegg kegg NA NA no no up no no up Taurine and hypotaurine metabolism Cholesterol metabolism 0 -0.438735178 0 yes kegg kegg NA NA no no no no no up Th1 and Th2 cell differentiation Cholesterol metabolism 0 0.538537549 0 yes kegg kegg NA NA no no no no no up Th17 cell differentiation Cholesterol metabolism 0 0.527667984 0 yes kegg kegg NA NA no no no no no up Thyroid hormone synthesis Cholesterol metabolism 0 -0.484189723 0 yes kegg kegg NA NA no no no no no up Toll-like receptor signaling pathway Cholesterol metabolism 0 0.442687747 0.490862291 yes yes kegg kegg NA NA no no no no no up Type I diabetes mellitus Cholesterol metabolism 0 0.701581028 0 yes kegg kegg NA NA no no no no no up Vasopressin-regulated water reabsorption Cholesterol metabolism 0 -0.433794466 -0.536422136 yes kegg kegg NA NA no no no no no up Vitamin digestion and absorption Cholesterol metabolism 0 0 0.407722008 yes kegg kegg NA NA no no no no no up Wnt signaling pathway Cholesterol metabolism 0 -0.432806324 0 yes kegg kegg NA NA no no no no no up 2-Oxocarboxylic acid metabolism Choline metabolism in cancer -0.624347826 -0.419960474 0 kegg kegg NA NA no no no no no no ABC transporters Choline metabolism in cancer 0 0.650197628 0 kegg kegg NA NA no up up no no no Acute myeloid leukemia Choline metabolism in cancer 0.533913043 0.627470356 0 kegg kegg NA NA no no no no no no Adherens junction Choline metabolism in cancer -0.453043478 -0.586956522 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Choline metabolism in cancer 0 0.513833992 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Choline metabolism in cancer 0.472173913 0 0 kegg kegg NA NA no no up no no no African trypanosomiasis Choline metabolism in cancer 0.485217391 0.459486166 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Choline metabolism in cancer 0 0.584980237 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Choline metabolism in cancer 0 0.498023715 0 kegg kegg NA NA no no no no no no Alcoholism Choline metabolism in cancer 0 0 -0.443758044 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Choline metabolism in cancer 0.764347826 0 0.468468468 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Choline metabolism in cancer -0.546956522 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Choline metabolism in cancer 0.449565217 -0.484189723 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Choline metabolism in cancer -0.599130435 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Choline metabolism in cancer -0.413043478 0 0 kegg kegg NA NA no no no no no no Amoebiasis Choline metabolism in cancer 0 0.481225296 -0.424453024 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Choline metabolism in cancer 0 -0.450592885 0 kegg kegg NA NA no no no no no no Antifolate resistance Choline metabolism in cancer 0 0 0.466924067 kegg kegg NA NA no no no no no no Antigen processing and presentation Choline metabolism in cancer 0 -0.585968379 -0.526126126 kegg kegg NA NA no no no no no no Apelin signaling pathway Choline metabolism in cancer 0 -0.660079051 0 kegg kegg NA NA no no no no no no Apoptosis Choline metabolism in cancer 0 0.45256917 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Choline metabolism in cancer 0 0.590909091 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Choline metabolism in cancer -0.580869565 0 -0.473101673 kegg kegg NA NA no no no no no no Arginine biosynthesis Choline metabolism in cancer 0 0.423913043 -0.482368082 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Choline metabolism in cancer -0.451304348 0 0 kegg kegg NA NA no no no no no no Autophagy - animal Choline metabolism in cancer 0.665217391 0.735177866 0.453796654 kegg kegg NA NA no no no no no no Autophagy - other Choline metabolism in cancer 0.599130435 0.513833992 0.607464607 kegg kegg NA NA no no no no no no Axon guidance Choline metabolism in cancer 0.482608696 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Choline metabolism in cancer 0.419130435 0.527667984 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Choline metabolism in cancer -0.58 -0.647233202 0 kegg kegg NA NA no no no no no no Bacteroides Choline metabolism in cancer 0 -0.45256917 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal cell carcinoma Choline metabolism in cancer 0.415652174 0 0.65997426 kegg kegg NA NA no no no no no no Basal transcription factors Choline metabolism in cancer 0 0 0.400772201 kegg kegg NA NA no no no no no no beta-Alanine metabolism Choline metabolism in cancer -0.769565217 -0.622529644 0 kegg kegg NA NA no no no no no no Bile secretion Choline metabolism in cancer 0 0 -0.454568855 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Choline metabolism in cancer -0.590434783 0 -0.574517375 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Choline metabolism in cancer -0.506956522 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Choline metabolism in cancer -0.590434783 -0.53458498 0 kegg kegg NA NA no no no no no no Bladder cancer Choline metabolism in cancer 0 0.583992095 0 kegg kegg NA NA no no no no no no Breast cancer Choline metabolism in cancer 0.910434783 0.920948617 0.851737452 kegg kegg NA NA no no no no no no Butanoate metabolism Choline metabolism in cancer -0.710434783 -0.604743083 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Choline metabolism in cancer 0.684347826 0.511857708 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Choline metabolism in cancer 0.546086957 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Choline metabolism in cancer 0.715652174 0.42687747 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Choline metabolism in cancer 0.792173913 0.770750988 0.719433719 kegg kegg NA NA no no no no no no Carbon metabolism Choline metabolism in cancer -0.737391304 -0.523715415 -0.455855856 kegg kegg NA NA no no no no no no Cell cycle Choline metabolism in cancer 0 0 0.51994852 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Choline metabolism in cancer 0.420869565 0 0 kegg kegg NA NA no no no no no no Chagas disease Choline metabolism in cancer 0.686956522 0.659090909 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Choline metabolism in cancer -0.562608696 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Choline metabolism in cancer 0.571304348 0.533596838 0 kegg kegg NA NA no no no no no no Cholinergic synapse Choline metabolism in cancer 0.694782609 0 0.789189189 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Choline metabolism in cancer 0.68173913 0.617588933 0.409266409 kegg kegg NA NA no no no no no no Circadian rhythm Choline metabolism in cancer 0.724347826 0 0.683397683 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Choline metabolism in cancer -0.625217391 -0.68972332 0 kegg kegg NA NA no no no no no no Clostridium Choline metabolism in cancer 0 -0.628602977 0 Genus kegg 0.925 NA no no no no no no Collecting duct acid secretion Choline metabolism in cancer 0 0 -0.409009009 kegg kegg NA NA no no no no no no Collinsella Choline metabolism in cancer 0 0 -0.441559892 Genus kegg 0.128 NA no no no no no no Colorectal cancer Choline metabolism in cancer 0.772173913 0.528656126 0.911196911 kegg kegg NA NA no no no no no no Complement and coagulation cascades Choline metabolism in cancer -0.507826087 0 -0.44993565 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Choline metabolism in cancer 0 -0.590909091 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Choline metabolism in cancer 0 -0.687747036 0 kegg kegg NA NA no no no no no no DNA replication Choline metabolism in cancer 0 -0.457509881 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Choline metabolism in cancer 0.437391304 0 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Choline metabolism in cancer -0.532173913 -0.705533597 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Choline metabolism in cancer -0.823478261 -0.77173913 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Choline metabolism in cancer 0 -0.510869565 0 kegg kegg NA NA no no no no no no Endocrine resistance Choline metabolism in cancer 0.553043478 0.472332016 0 kegg kegg NA NA no no no no no no Endometrial cancer Choline metabolism in cancer 0.74173913 0.738142292 0.688288288 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Choline metabolism in cancer 0 -0.447628458 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Choline metabolism in cancer 0.827826087 0.800395257 0.838352638 kegg kegg NA NA no no no no no no Ether lipid metabolism Choline metabolism in cancer 0 0 0.472072072 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Choline metabolism in cancer 0 0.558300395 0 kegg kegg NA NA no no no no no no Fatty acid elongation Choline metabolism in cancer -0.764347826 -0.686758893 -0.411840412 kegg kegg NA NA no no no no no no Fatty acid metabolism Choline metabolism in cancer -0.426956522 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Choline metabolism in cancer 0.603478261 0.602766798 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Choline metabolism in cancer 0 0 -0.506821107 kegg kegg NA NA no no no no no no Ferroptosis Choline metabolism in cancer 0 0 -0.493951094 kegg kegg NA NA no no no no no no Focal adhesion Choline metabolism in cancer -0.445217391 -0.68972332 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Choline metabolism in cancer 0 0.75 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Choline metabolism in cancer -0.530434783 0.608695652 0 kegg kegg NA NA no no no no no no Galactose metabolism Choline metabolism in cancer -0.549565217 0.533596838 0 kegg kegg NA NA no no no no no no Gastric acid secretion Choline metabolism in cancer -0.412173913 -0.566205534 0 kegg kegg NA NA no no no no no no Gastric cancer Choline metabolism in cancer 0.602608696 0.691699605 0.787387387 kegg kegg NA NA no no no no no no Glioma Choline metabolism in cancer 0.697391304 0 0.705276705 kegg kegg NA NA no no no no no no Glutamatergic synapse Choline metabolism in cancer 0 0.498023715 -0.440926641 kegg kegg NA NA no up up no no no Glutathione metabolism Choline metabolism in cancer -0.433913043 -0.490118577 -0.476962677 kegg kegg NA NA no no no no no no Glycerolipid metabolism Choline metabolism in cancer 0 0.736166008 0.677992278 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Choline metabolism in cancer 0.44 0.672924901 0.697039897 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Choline metabolism in cancer -0.73826087 -0.773715415 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Choline metabolism in cancer 0 0.828063241 0.490862291 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Choline metabolism in cancer -0.567826087 0 0.596911197 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Choline metabolism in cancer 0.416521739 0 0.547747748 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Choline metabolism in cancer 0 0 0.415444015 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Choline metabolism in cancer 0.523478261 0.497035573 0.491634492 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Choline metabolism in cancer 0 0 -0.462290862 kegg kegg NA NA no no no no no no GnRH secretion Choline metabolism in cancer 0.875652174 0.838932806 0.866666667 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Choline metabolism in cancer 0.78 0.809288538 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Choline metabolism in cancer 0.519130435 0 0.759073359 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Choline metabolism in cancer 0 -0.539525692 0 kegg kegg NA NA no no no no no no Hepatitis B Choline metabolism in cancer 0.64 0.706521739 0.466409266 kegg kegg NA NA no no no no no no Hepatitis C Choline metabolism in cancer 0.5 0 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Choline metabolism in cancer 0 -0.420948617 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Choline metabolism in cancer 0 -0.632411067 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Choline metabolism in cancer -0.46 -0.583992095 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Choline metabolism in cancer 0 0 0.462548263 kegg kegg NA NA no no no no no no Histidine metabolism Choline metabolism in cancer -0.514782609 0 0 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Choline metabolism in cancer 0 0 -0.427541828 kegg kegg NA NA no no dn no no no Human immunodeficiency virus 1 infection Choline metabolism in cancer 0 0 -0.419047619 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Choline metabolism in cancer 0 -0.485177866 0 kegg kegg NA NA no no no no no no Huntington disease Choline metabolism in cancer 0.431304348 -0.457509881 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Choline metabolism in cancer 0 0.684782609 0.710939511 kegg kegg NA NA no no no no no no Insulin resistance Choline metabolism in cancer 0.785217391 0.78458498 0.530759331 kegg kegg NA NA no no no no no no Insulin signaling pathway Choline metabolism in cancer 0 -0.631422925 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Choline metabolism in cancer 0 0.815217391 0 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Choline metabolism in cancer 0 0 -0.473616474 kegg kegg NA NA no no dn no no no Legionellosis Choline metabolism in cancer 0 0 -0.477734878 kegg kegg NA NA no no no no no no Leishmaniasis Choline metabolism in cancer -0.506086957 -0.504940711 -0.504247104 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Choline metabolism in cancer 0 -0.481225296 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Choline metabolism in cancer -0.555652174 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Choline metabolism in cancer 0.426086957 -0.608695652 0.506821107 kegg kegg NA NA no no up no no no Longevity regulating pathway Choline metabolism in cancer 0.545217391 0.4743083 0 kegg kegg NA NA no no no no no no Lysine degradation Choline metabolism in cancer 0 0.41798419 0.744144144 kegg kegg NA NA no no no no no no Malaria Choline metabolism in cancer 0 0 -0.527927928 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Choline metabolism in cancer 0.543478261 0.466403162 0.73951094 kegg kegg NA NA no no no no no no MAPK signaling pathway Choline metabolism in cancer 0 0.419960474 0.764221364 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Choline metabolism in cancer 0 0 0.480823681 kegg kegg NA NA no up no no no no Melanoma Choline metabolism in cancer 0.852173913 0.741106719 0.66975547 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Choline metabolism in cancer -0.645217391 -0.73715415 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Choline metabolism in cancer 0.445217391 0.700592885 0.733848134 kegg kegg NA NA no no no no no no Mineral absorption Choline metabolism in cancer 0 0 -0.474903475 kegg kegg NA NA no no no no no no Mismatch repair Choline metabolism in cancer -0.475652174 -0.515810277 0 kegg kegg NA NA no no no no no no Mitophagy - animal Choline metabolism in cancer 0 0 -0.431660232 kegg kegg NA NA no no no no no no mRNA surveillance pathway Choline metabolism in cancer 0.614782609 0 0.655598456 kegg kegg NA NA no no no no no no mTOR signaling pathway Choline metabolism in cancer 0 -0.53458498 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Choline metabolism in cancer 0 0 0.406692407 kegg kegg NA NA no no no no no no Necroptosis Choline metabolism in cancer 0 0 -0.528700129 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Choline metabolism in cancer 0.679130435 0.428853755 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Choline metabolism in cancer 0 0 -0.519433719 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Choline metabolism in cancer 0 0.705533597 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Choline metabolism in cancer 0 0.511857708 0 kegg kegg NA NA no no no no no no Nicotine addiction Choline metabolism in cancer 0 0.550395257 0 kegg kegg NA NA no up up no no no NOD-like receptor signaling pathway Choline metabolism in cancer 0 0.447628458 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Choline metabolism in cancer 0.497391304 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Choline metabolism in cancer -0.714782609 -0.672924901 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Choline metabolism in cancer 0.84173913 0.862648221 0.851222651 kegg kegg NA NA no no no no no no Notch signaling pathway Choline metabolism in cancer 0.546956522 0.782608696 0.763706564 kegg kegg NA NA no no no no no no Oocyte meiosis Choline metabolism in cancer 0 -0.720355731 0 kegg kegg NA NA no no no no no no Other glycan degradation Choline metabolism in cancer 0 0.509881423 0.531531532 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Choline metabolism in cancer 0.463478261 0.479249012 0.698841699 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Choline metabolism in cancer 0 0 -0.421106821 kegg kegg NA NA no up up no no no Oxidative phosphorylation Choline metabolism in cancer 0 -0.469367589 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Choline metabolism in cancer -0.424347826 -0.428853755 -0.439124839 kegg kegg NA NA no no no no no no p53 signaling pathway Choline metabolism in cancer 0.559130435 0.561264822 0 kegg kegg NA NA no no no no no no Pancreatic cancer Choline metabolism in cancer 0.48 0 0.524066924 kegg kegg NA NA no no no no no no Paraprevotella Choline metabolism in cancer -0.505831203 0 0 Genus kegg 0.118 NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Choline metabolism in cancer 0.489565217 0 0 kegg kegg NA NA no no no no no no Parkinson disease Choline metabolism in cancer 0 -0.467391304 0 kegg kegg NA NA no no no no no no Pathways in cancer Choline metabolism in cancer 0.706956522 0.776679842 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Choline metabolism in cancer 0 -0.45256917 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Choline metabolism in cancer -0.663478261 -0.581027668 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Choline metabolism in cancer 0 0 -0.423166023 kegg kegg NA NA no no no no no no Peroxisome Choline metabolism in cancer 0 0 -0.529472329 kegg kegg NA NA no no no no no no Phagosome Choline metabolism in cancer 0 0 -0.43989704 kegg kegg NA NA no no no no no no Phenylalanine metabolism Choline metabolism in cancer -0.716521739 -0.545454545 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Choline metabolism in cancer 0.631304348 0 0.791248391 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Choline metabolism in cancer 0 0.746047431 0 kegg kegg NA NA no up up no no no Phototransduction Choline metabolism in cancer 0 -0.846837945 0 kegg kegg NA NA no no no no no no Platelet activation Choline metabolism in cancer -0.43826087 -0.518774704 0 kegg kegg NA NA no no no no no no Platinum drug resistance Choline metabolism in cancer 0 0.552371542 0.411583012 kegg kegg NA NA no no no no no no Prevotella Choline metabolism in cancer 0 0.539966901 0 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Choline metabolism in cancer -0.565217391 -0.666996047 0 kegg kegg NA NA no no no no no no Prion disease Choline metabolism in cancer 0 -0.584980237 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Choline metabolism in cancer 0.520869565 0.531620553 0.654311454 kegg kegg NA NA no no no no no no Prolactin signaling pathway Choline metabolism in cancer 0.716521739 0.712450593 0.455855856 kegg kegg NA NA no no no no no no Propanoate metabolism Choline metabolism in cancer -0.454782609 -0.692687747 0 kegg kegg NA NA no no no no no no Prostate cancer Choline metabolism in cancer 0.759130435 0.585968379 0 kegg kegg NA NA no no no no no no Proteasome Choline metabolism in cancer 0 -0.781620553 0 kegg kegg NA NA no no no no no no Protein export Choline metabolism in cancer 0 -0.681818182 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Choline metabolism in cancer 0 -0.572134387 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Choline metabolism in cancer 0 -0.565217391 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Choline metabolism in cancer -0.63826087 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Choline metabolism in cancer -0.445217391 -0.670948617 -0.400514801 kegg kegg NA NA no no no no no no Ras signaling pathway Choline metabolism in cancer 0 -0.448616601 0.597940798 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Choline metabolism in cancer -0.649565217 -0.754940711 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Choline metabolism in cancer 0.702608696 0.593873518 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Choline metabolism in cancer 0.552173913 0 0 kegg kegg NA NA no no no no no no Renin secretion Choline metabolism in cancer 0 -0.48715415 0 kegg kegg NA NA no no no no no no Retinol metabolism Choline metabolism in cancer -0.568695652 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Choline metabolism in cancer 0 -0.602766798 0 kegg kegg NA NA no no up no no no Ribosome Choline metabolism in cancer 0 -0.58201581 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Choline metabolism in cancer 0 0 0.434749035 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Choline metabolism in cancer 0.493913043 0.634387352 0 kegg kegg NA NA no no no no no no RNA degradation Choline metabolism in cancer 0.567826087 0 0.612355212 kegg kegg NA NA no no no no no no RNA transport Choline metabolism in cancer 0 -0.502964427 0 kegg kegg NA NA no no no no no no Salivary secretion Choline metabolism in cancer 0 0 -0.438867439 kegg kegg NA NA no no no no no no Salmonella infection Choline metabolism in cancer -0.446086957 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Choline metabolism in cancer 0 0 0.442985843 kegg kegg NA NA no no no no no no Shigellosis Choline metabolism in cancer 0 -0.427865613 -0.544658945 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Choline metabolism in cancer 0.812173913 0.636363636 0.77966538 kegg kegg NA NA no no no no no no Small cell lung cancer Choline metabolism in cancer 0.557391304 0.696640316 0 kegg kegg NA NA no no up no no no SNARE interactions in vesicular transport Choline metabolism in cancer 0 0.507905138 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Choline metabolism in cancer 0.682608696 0 0.585070785 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Choline metabolism in cancer 0.675652174 0 0.497297297 kegg kegg NA NA no no no no no no Spliceosome Choline metabolism in cancer 0 0 0.468725869 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Choline metabolism in cancer -0.512173913 0 -0.499356499 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Choline metabolism in cancer 0 0.483201581 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Choline metabolism in cancer 0 -0.471343874 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Choline metabolism in cancer -0.634782609 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Choline metabolism in cancer -0.580869565 -0.523715415 -0.441184041 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Choline metabolism in cancer 0 0.469367589 0 kegg kegg NA NA no no no no no no Taste transduction Choline metabolism in cancer 0 0 0.669498069 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Choline metabolism in cancer 0.5 0.804347826 0.476447876 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Choline metabolism in cancer 0 0 0.421364221 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Choline metabolism in cancer 0 -0.648221344 0.515057915 kegg kegg NA NA no no no no no no Thermogenesis Choline metabolism in cancer 0 -0.492094862 0 kegg kegg NA NA no no no no no no Thiamine metabolism Choline metabolism in cancer 0 -0.564229249 0 kegg kegg NA NA no no no no no no Thyroid cancer Choline metabolism in cancer 0 -0.45256917 0 kegg kegg NA NA no no no no no no Tight junction Choline metabolism in cancer -0.588695652 -0.734189723 -0.465122265 kegg kegg NA NA no no no no no no TNF signaling pathway Choline metabolism in cancer 0.77826087 0.666007905 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Choline metabolism in cancer 0.610434783 0.502964427 0 yes kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Choline metabolism in cancer 0.512173913 0.7243083 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Choline metabolism in cancer -0.713913043 -0.652173913 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Choline metabolism in cancer 0.855652174 0.834980237 0.598970399 kegg kegg NA NA no no no no no no Tyrosine metabolism Choline metabolism in cancer -0.672173913 -0.528656126 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Choline metabolism in cancer -0.591304348 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Choline metabolism in cancer 0 0 -0.421879022 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Choline metabolism in cancer -0.57826087 -0.502964427 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Choline metabolism in cancer 0 -0.546442688 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Choline metabolism in cancer 0.780869565 0.558300395 0.73024453 kegg kegg NA NA no no no no no no Vibrio cholerae infection Choline metabolism in cancer 0 -0.5 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Choline metabolism in cancer 0 0 -0.511711712 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Choline metabolism in cancer 0.514782609 0 0.476447876 kegg kegg NA NA no no no no no no Wnt signaling pathway Choline metabolism in cancer 0 0 0.750579151 kegg kegg NA NA no no no no no no 14:0/18:2-PC+blood Choline+blood -0.461654135 0 0 serum_phospholipids serum_choline 0.102 0.0395 no up no no up no 14:0/20:4-PC+blood Choline+blood -0.45112782 0 0 serum_phospholipids serum_choline 0.486 0.0395 no no no no up no 15-HETE+blood Choline+blood 0 0 -0.433622152 serum_ARA serum_choline 0.819 0.0395 no no no no up no 16:0-LPC+blood Choline+blood 0 0.544117647 0 serum_phospholipids serum_choline 0.00456 0.0395 up up no no up no 16:0/18:0-PS+blood Choline+blood 0 -0.585784314 0 serum_phospholipids serum_choline 0.377 0.0395 no no no no up no 16:0/20:5-PC+blood Choline+blood -0.527819549 0 0 serum_phospholipids serum_choline 0.628 0.0395 no no no no up no 16:0/22:6-PE+blood Choline+blood 0 -0.529411765 0 serum_phospholipids serum_choline 0.000934 0.0395 up up no no up no 18:0/18:0-PS+blood Choline+blood 0 -0.620098039 0 serum_phospholipids serum_choline 0.00617 0.0395 no up no no up no 18:0/22:6-PC+blood Choline+blood 0 -0.509803922 0 serum_phospholipids serum_choline 0.0775 0.0395 no no up no up no 18:0/22:6-PE+blood Choline+blood 0 -0.588235294 0 serum_phospholipids serum_choline 0.00022 0.0395 up up no no up no 18:0/22:6-PI+blood Choline+blood 0 -0.5 0 serum_phospholipids serum_choline 0.425 0.0395 no no no no up no 18:1-LPC+blood Choline+blood 0.538345865 0 0 serum_phospholipids serum_choline 0.179 0.0395 no no no no up no 18:1/18:0-PS+blood Choline+blood 0 -0.590686275 0 serum_phospholipids serum_choline 0.193 0.0395 no no no no up no 18:1/20:4-PE+blood Choline+blood 0 -0.531862745 0 serum_phospholipids serum_choline 0.0578 0.0395 up no no no up no 18:1/22:6-PE+blood Choline+blood 0 -0.549019608 0 serum_phospholipids serum_choline 0.0047 0.0395 no up no no up no 18:2-LPA+blood Choline+blood 0 0.656862745 0 serum_phospholipids serum_choline 0.00684 0.0395 dn no up no up no 18:2-LPC+blood Choline+blood 0 0.529411765 0 serum_phospholipids serum_choline 0.00743 0.0395 dn no up no up no 18:3n6+blood Choline+blood -0.609022556 0 0 serum_fattyacid serum_choline 0.0463 0.0395 up no dn no up no 20:0+blood Choline+blood 0 0 0.445470085 yes serum_fattyacid serum_choline 0.000278 0.0395 dn no up no up no 20:2-LPC+blood Choline+blood 0.45112782 0 0 serum_phospholipids serum_choline 0.119 0.0395 no no up no up no 20:3-LPE+blood Choline+blood 0 0 0.448205128 serum_phospholipids serum_choline 0.084 0.0395 no up no no up no 20:5-LPC+blood Choline+blood -0.467669173 0 0 serum_phospholipids serum_choline 0.558 0.0395 no no no no up no 20:5n3+blood Choline+blood -0.523308271 0 0 serum_fattyacid serum_choline 0.988 0.0395 no no no no up no AA+blood Choline+blood 0 0 0.424957265 serum_ARA serum_choline 0.212 0.0395 no no no no up no Arachidonic acid metabolism Choline+blood 0 0 0.420769231 kegg serum_choline NA 0.0395 no no no no up no B cell receptor signaling pathway Choline+blood 0.475438596 0 0.492307692 kegg serum_choline NA 0.0395 no no no no up no Betaine+blood Choline+blood 0.661654135 0.801470588 0 serum_choline serum_choline 0.857 0.0395 no no no no up no Biosynthesis of amino acids Choline+blood -0.470175439 0 0 kegg serum_choline NA 0.0395 no no no no up no cAMP signaling pathway Choline+blood 0.507017544 0 0 yes kegg serum_choline NA 0.0395 no up up no up no Carbon metabolism Choline+blood -0.470175439 0 0 kegg serum_choline NA 0.0395 no no no no up no Cell cycle Choline+blood 0 0 -0.408461538 kegg serum_choline NA 0.0395 no no no no up no Central carbon metabolism in cancer Choline+blood 0 0 -0.443846154 kegg serum_choline NA 0.0395 no no no no up no Chronic myeloid leukemia Choline+blood 0.524561404 0 0.528461538 kegg serum_choline NA 0.0395 no no no no up no Colorectal cancer Choline+blood 0.464912281 0 0 kegg serum_choline NA 0.0395 no no no no up no Coprococcus Choline+blood -0.496240602 0 0 butyrate-producing Genus serum_choline 0.612 0.0395 no no no no up no Glycolysis / Gluconeogenesis Choline+blood -0.545614035 0 -0.55 kegg serum_choline NA 0.0395 no no no no up no Hematopoietic cell lineage Choline+blood 0 0 -0.439230769 kegg serum_choline NA 0.0395 no no no no up no Intestinal immune network for IgA production Choline+blood 0 0 -0.414615385 kegg serum_choline NA 0.0395 no no no no up no Kaposi sarcoma-associated herpesvirus infection Choline+blood 0 0.544117647 0 kegg serum_choline NA 0.0395 no no dn no up no Lachnospira Choline+blood 0 0 0.462329445 butyrate-producing Genus serum_choline 0.279 0.0395 no no no no up no Long-term potentiation Choline+blood 0 0 -0.424615385 kegg serum_choline NA 0.0395 no no up no up no mRNA surveillance pathway Choline+blood 0.526315789 0 0 kegg serum_choline NA 0.0395 no no no no up no NF-kappa B signaling pathway Choline+blood 0 0 0.408461538 kegg serum_choline NA 0.0395 no no no no up no Non-alcoholic fatty liver disease Choline+blood 0.459649123 0 0 kegg serum_choline NA 0.0395 no no no no up no Odoribacter Choline+blood 0 0 0.64175419 butyrate-producing Genus serum_choline 0.798 0.0395 no no no no up no Oocyte meiosis Choline+blood 0 0 -0.494615385 kegg serum_choline NA 0.0395 no no no no up no Pancreatic cancer Choline+blood 0 -0.502941176 0 kegg serum_choline NA 0.0395 no no no no up no Parabacteroides Choline+blood 0 0 0.485211154 Genus serum_choline 4.19E-05 0.0395 no up up no up no Pathways in cancer Choline+blood 0.49122807 0 0 kegg serum_choline NA 0.0395 no no no no up no Phosphatidylinositol signaling system Choline+blood 0 -0.55 0 kegg serum_choline NA 0.0395 no no no no up no Primary immunodeficiency Choline+blood -0.51754386 0 -0.432307692 kegg serum_choline NA 0.0395 no no no no up no Ras signaling pathway Choline+blood 0 -0.614705882 0 yes kegg serum_choline NA 0.0395 no up up no up no Relaxin signaling pathway Choline+blood 0.51754386 0 0 kegg serum_choline NA 0.0395 no no no no up no Signaling pathways regulating pluripotency of stem cells Choline+blood 0.487719298 0 0 kegg serum_choline NA 0.0395 no no no no up no Spliceosome Choline+blood 0 0 -0.420769231 kegg serum_choline NA 0.0395 no no no no up no TCA+stool Choline+blood -0.696011663 0 0 stool_bileacids serum_choline 0.458 0.0395 no no no no up no Wnt signaling pathway Choline+blood 0.480701754 0 0 kegg serum_choline NA 0.0395 no no no no up no 2-Oxocarboxylic acid metabolism Cholinergic synapse -0.534782609 0 0 kegg kegg NA NA no no no no no no Adherens junction Cholinergic synapse -0.511304348 0 0 kegg kegg NA NA no no no no no no Akkermansia Cholinergic synapse 0 -0.414110093 0 acetate-producing Genus kegg 0.23 NA no no no no no no Alistipes Cholinergic synapse -0.514415385 0 0 Genus kegg 0.0114 NA no up no no no no AMPK signaling pathway Cholinergic synapse 0 0 -0.482368082 kegg kegg NA NA no no no no no no Arginine and proline metabolism Cholinergic synapse 0 0.427865613 0 kegg kegg NA NA no up no no no no Ascorbate and aldarate metabolism Cholinergic synapse -0.411304348 0 0 kegg kegg NA NA no no no no no no Autophagy - animal Cholinergic synapse 0.66173913 0 0.437065637 kegg kegg NA NA no no no no no no Autophagy - other Cholinergic synapse 0.540869565 0 0.517889318 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Cholinergic synapse 0 0 0.410553411 kegg kegg NA NA no no no no no no beta-Alanine metabolism Cholinergic synapse -0.53826087 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Cholinergic synapse -0.52 0 -0.402831403 kegg kegg NA NA no no no no no no Butanoate metabolism Cholinergic synapse -0.536521739 0 0 kegg kegg NA NA no no no no no no Butyricimonas Cholinergic synapse 0 0.416033771 0 butyrate-producing Genus kegg 0.17 NA no no no no no no C-type lectin receptor signaling pathway Cholinergic synapse 0.546956522 0 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Cholinergic synapse 0.487826087 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Cholinergic synapse -0.405217391 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Cholinergic synapse 0 -0.416996047 0 kegg kegg NA NA no no up no no no cGMP-PKG signaling pathway Cholinergic synapse 0.546956522 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Cholinergic synapse 0.492173913 0 0.560617761 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Cholinergic synapse -0.44 0 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Cholinergic synapse 0 0.527667984 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Cholinergic synapse -0.42173913 0 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Cholinergic synapse 0 0.414031621 0 kegg kegg NA NA no up up no no no ErbB signaling pathway Cholinergic synapse 0.594782609 0 0.754697555 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Cholinergic synapse 0.408695652 0.449604743 0 kegg kegg NA NA no no no no no no Fatty acid elongation Cholinergic synapse -0.443478261 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Cholinergic synapse 0 0.450592885 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Cholinergic synapse 0 0 0.475675676 kegg kegg NA NA no no no no no no Ferroptosis Cholinergic synapse 0 0 -0.492921493 kegg kegg NA NA no no no no no no FoxO signaling pathway Cholinergic synapse 0.570434783 0.471343874 0 kegg kegg NA NA no no no no no no Glutathione metabolism Cholinergic synapse -0.420869565 0 -0.425482625 kegg kegg NA NA no no no no no no Glycerolipid metabolism Cholinergic synapse 0 0 0.48030888 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Cholinergic synapse 0 0 0.445045045 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Cholinergic synapse -0.405217391 0 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Cholinergic synapse 0 0 0.504247104 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Cholinergic synapse -0.527826087 0 0.54980695 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Cholinergic synapse 0 0 0.507335907 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Cholinergic synapse 0 0 0.476447876 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Cholinergic synapse 0 0 0.436550837 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Cholinergic synapse 0 0 0.603603604 kegg kegg NA NA no no no no no no Hippo signaling pathway Cholinergic synapse -0.48173913 -0.416996047 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Cholinergic synapse 0 0 0.580952381 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Cholinergic synapse 0 0 0.43963964 kegg kegg NA NA no no no no no no Linoleic acid metabolism Cholinergic synapse -0.450434783 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Cholinergic synapse 0.584347826 0 0.611325611 kegg kegg NA NA no no up no no no Longevity regulating pathway - multiple species Cholinergic synapse 0 0 -0.500900901 kegg kegg NA NA no no no no no no Lysine degradation Cholinergic synapse 0 0 0.556756757 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Cholinergic synapse 0 0 0.595624196 kegg kegg NA NA no no no no no no MAPK signaling pathway Cholinergic synapse 0.625217391 0.453557312 0.647619048 kegg kegg NA NA no no no no no no Mitophagy - animal Cholinergic synapse 0 0 -0.542084942 kegg kegg NA NA no no no no no no mRNA surveillance pathway Cholinergic synapse 0 0 0.430630631 kegg kegg NA NA no no no no no no Necroptosis Cholinergic synapse 0 0 -0.536164736 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Cholinergic synapse 0.469565217 0 0.53951094 kegg kegg NA NA no no no no no no Non-homologous end-joining Cholinergic synapse 0 0 -0.408751609 kegg kegg NA NA no no no no no no Notch signaling pathway Cholinergic synapse 0 0 0.670785071 kegg kegg NA NA no no no no no no Other glycan degradation Cholinergic synapse 0 0 0.5003861 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Cholinergic synapse 0 0 0.479279279 kegg kegg NA NA no no no no no no Oxidative phosphorylation Cholinergic synapse 0 -0.415019763 0 kegg kegg NA NA no no no no no no p53 signaling pathway Cholinergic synapse 0.435652174 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Cholinergic synapse -0.407826087 0 0 kegg kegg NA NA no no no no no no Peroxisome Cholinergic synapse 0 0 -0.589446589 kegg kegg NA NA no no no no no no Phenylalanine metabolism Cholinergic synapse -0.606086957 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Cholinergic synapse 0 0 0.558301158 kegg kegg NA NA no no no no no no Platinum drug resistance Cholinergic synapse 0.457391304 0 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Cholinergic synapse 0 0 -0.420849421 kegg kegg NA NA no no no no no no Proteasome Cholinergic synapse 0 -0.468379447 0 kegg kegg NA NA no no no no no no Protein export Cholinergic synapse 0 -0.441699605 0 kegg kegg NA NA no no no no no no Purine metabolism Cholinergic synapse 0 0 -0.452509653 kegg kegg NA NA no no no no no no Pyruvate metabolism Cholinergic synapse 0 0 -0.530501931 kegg kegg NA NA no no no no no no Ras signaling pathway Cholinergic synapse 0 0 0.621621622 yes kegg kegg NA NA no up up no no no Ribosome Cholinergic synapse 0 0 -0.404118404 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Cholinergic synapse 0.499130435 0 0 kegg kegg NA NA no no no no no no RNA degradation Cholinergic synapse 0 0 0.446589447 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Cholinergic synapse 0.574782609 0 0.586872587 kegg kegg NA NA no no no no no no Sphingolipid metabolism Cholinergic synapse 0 0 0.478249678 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Cholinergic synapse 0.632173913 0 0.565250965 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Cholinergic synapse 0 0.418972332 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Cholinergic synapse -0.45826087 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Cholinergic synapse -0.635652174 0 -0.436036036 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Cholinergic synapse 0.466086957 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Cholinergic synapse 0 0 0.545688546 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Cholinergic synapse 0 0 0.496782497 kegg kegg NA NA no no no no no no Th17 cell differentiation Cholinergic synapse 0 0 0.441184041 kegg kegg NA NA no no no no no no Tight junction Cholinergic synapse -0.559130435 0 0 kegg kegg NA NA no no no no no no TNF signaling pathway Cholinergic synapse 0.531304348 0 0.451480051 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Cholinergic synapse 0.546086957 0 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Cholinergic synapse -0.464347826 0 0 kegg kegg NA NA no up no no no no Ubiquinone and other terpenoid-quinone biosynthesis Cholinergic synapse -0.419130435 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Cholinergic synapse 0 -0.414031621 -0.558043758 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Cholinergic synapse -0.437391304 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Cholinergic synapse 0.432173913 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Cholinergic synapse 0.60173913 0 0.687516088 kegg kegg NA NA no no no no no no Wnt signaling pathway Cholinergic synapse 0 0 0.607979408 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Chronic myeloid leukemia 0 0 -0.404118404 kegg kegg NA NA no no no no no no Adherens junction Chronic myeloid leukemia 0 -0.475296443 -0.476190476 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Chronic myeloid leukemia 0.452173913 0.729249012 0.475675676 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Chronic myeloid leukemia 0 0.488142292 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Chronic myeloid leukemia 0 0.420948617 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Chronic myeloid leukemia 0.491304348 0.548418972 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Chronic myeloid leukemia -0.530434783 0 0 kegg kegg NA NA no no no no no no Amoebiasis Chronic myeloid leukemia 0 0.485177866 0 kegg kegg NA NA no no no no no no Amphetamine addiction Chronic myeloid leukemia 0 -0.506916996 0 kegg kegg NA NA no no no no no no Anaerostipes Chronic myeloid leukemia 0 0 -0.471941609 butyrate-producing Genus kegg 0.568 NA no no no no no no Apelin signaling pathway Chronic myeloid leukemia 0 -0.496047431 0 kegg kegg NA NA no no no no no no Apoptosis Chronic myeloid leukemia 0 0.68972332 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Chronic myeloid leukemia -0.534782609 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Chronic myeloid leukemia 0 0.459486166 0 kegg kegg NA NA no up no no no no Autophagy - animal Chronic myeloid leukemia 0.516521739 0.7243083 0 kegg kegg NA NA no no no no no no Autophagy - other Chronic myeloid leukemia 0.580869565 0.516798419 0 kegg kegg NA NA no no no no no no Axon guidance Chronic myeloid leukemia 0.532173913 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Chronic myeloid leukemia 0.616521739 0.801383399 0.763191763 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Chronic myeloid leukemia -0.406086957 -0.455533597 -0.587644788 kegg kegg NA NA no no no no no no Bacteroides Chronic myeloid leukemia 0 -0.425889328 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal cell carcinoma Chronic myeloid leukemia 0.577391304 0 0.522265122 kegg kegg NA NA no no no no no no beta-Alanine metabolism Chronic myeloid leukemia -0.537391304 -0.690711462 -0.677992278 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Chronic myeloid leukemia 0 -0.556324111 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Chronic myeloid leukemia -0.635652174 -0.758893281 -0.781981982 kegg kegg NA NA no no no no no no Bladder cancer Chronic myeloid leukemia 0 0.609683794 0 kegg kegg NA NA no no no no no no Butanoate metabolism Chronic myeloid leukemia -0.417391304 -0.726284585 -0.635263835 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Chronic myeloid leukemia 0.700869565 0.821146245 0.77992278 kegg kegg NA NA no no no no no no cAMP signaling pathway Chronic myeloid leukemia 0.466086957 0.758893281 0.592535393 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Chronic myeloid leukemia 0.671304348 0.651185771 0 kegg kegg NA NA no no no no no no Carbon metabolism Chronic myeloid leukemia -0.479130435 0 0 kegg kegg NA NA no no no no no no Cellular senescence Chronic myeloid leukemia 0 0.575098814 0 kegg kegg NA NA no no no no no no Chagas disease Chronic myeloid leukemia 0.625217391 0.811264822 0.546718147 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Chronic myeloid leukemia -0.569565217 0 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Chronic myeloid leukemia 0.434782609 0.467391304 0 kegg kegg NA NA no no no no no no Circadian entrainment Chronic myeloid leukemia -0.519130435 -0.699604743 0 kegg kegg NA NA no up up no no no Circadian rhythm Chronic myeloid leukemia 0.540869565 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Chronic myeloid leukemia -0.533913043 -0.725296443 -0.421621622 kegg kegg NA NA no no no no no no Collecting duct acid secretion Chronic myeloid leukemia -0.429565217 -0.599802372 0 kegg kegg NA NA no no no no no no Colorectal cancer Chronic myeloid leukemia 0.589565217 0 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Chronic myeloid leukemia -0.469565217 -0.731225296 -0.562676963 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Chronic myeloid leukemia 0 0 -0.543114543 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Chronic myeloid leukemia 0.452173913 0.866600791 0.506306306 kegg kegg NA NA no no no no no no DNA replication Chronic myeloid leukemia 0 -0.673913043 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Chronic myeloid leukemia 0 -0.522727273 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Chronic myeloid leukemia -0.495652174 -0.716403162 -0.5001287 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Chronic myeloid leukemia -0.590434783 -0.632411067 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Chronic myeloid leukemia 0 -0.475296443 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Chronic myeloid leukemia 0.443478261 0 0 kegg kegg NA NA no no no no no no Endometrial cancer Chronic myeloid leukemia 0.79826087 0.841897233 0.568597169 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Chronic myeloid leukemia 0.467826087 0.627470356 0.427284427 kegg kegg NA NA no no no no no no ErbB signaling pathway Chronic myeloid leukemia 0.730434783 0.639328063 0.406949807 kegg kegg NA NA no no no no no no Estrogen signaling pathway Chronic myeloid leukemia -0.58 -0.758893281 -0.463577864 kegg kegg NA NA no no no no no no Fatty acid elongation Chronic myeloid leukemia -0.64 -0.679841897 -0.825482625 kegg kegg NA NA no no no no no no Fatty acid metabolism Chronic myeloid leukemia -0.431304348 0 -0.402574003 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Chronic myeloid leukemia 0.484347826 0.645256917 0 kegg kegg NA NA no no no no no no Focal adhesion Chronic myeloid leukemia -0.407826087 -0.591897233 -0.548777349 kegg kegg NA NA no up up no no no Gastric acid secretion Chronic myeloid leukemia -0.483478261 -0.54743083 -0.468211068 kegg kegg NA NA no no no no no no Glucagon signaling pathway Chronic myeloid leukemia 0 -0.425889328 0 kegg kegg NA NA no no no no no no Glutathione metabolism Chronic myeloid leukemia 0 -0.507905138 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Chronic myeloid leukemia -0.574782609 -0.623517787 -0.607979408 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Chronic myeloid leukemia 0 0.699604743 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Chronic myeloid leukemia 0.411304348 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Chronic myeloid leukemia -0.414782609 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Chronic myeloid leukemia 0.573043478 0.609683794 0.496525097 kegg kegg NA NA no no no no no no GnRH secretion Chronic myeloid leukemia 0.677391304 0.696640316 0 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Chronic myeloid leukemia 0 0.424901186 0.558043758 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Chronic myeloid leukemia 0 -0.491106719 -0.598712999 kegg kegg NA NA no no no no no no Hepatitis B Chronic myeloid leukemia 0.673913043 0.727272727 0.81003861 kegg kegg NA NA no no no no no no Hepatitis C Chronic myeloid leukemia 0.542608696 0.860671937 0.752895753 kegg kegg NA NA no no no no no no Hippo signaling pathway Chronic myeloid leukemia 0 -0.483201581 -0.514028314 kegg kegg NA NA no no no no no no Histidine metabolism Chronic myeloid leukemia -0.45826087 0 -0.408494208 kegg kegg NA NA no no no no no no Human papillomavirus infection Chronic myeloid leukemia 0 0.62944664 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Chronic myeloid leukemia 0 -0.453557312 0 kegg kegg NA NA no no no no no no Insulin resistance Chronic myeloid leukemia 0.78 0.899209486 0.774517375 kegg kegg NA NA no no no no no no Insulin signaling pathway Chronic myeloid leukemia 0 -0.444664032 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Chronic myeloid leukemia 0 0.588932806 0 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Chronic myeloid leukemia 0.508695652 0 0 kegg kegg NA NA no no dn no no no Lachnospira Chronic myeloid leukemia 0 -0.434395862 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Long-term potentiation Chronic myeloid leukemia 0 -0.612648221 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Chronic myeloid leukemia 0.415652174 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Chronic myeloid leukemia -0.471304348 -0.423913043 -0.594594595 kegg kegg NA NA no no no no no no Lysine degradation Chronic myeloid leukemia 0.62173913 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Chronic myeloid leukemia 0.766956522 0.427865613 0 kegg kegg NA NA no no no no no no Melanoma Chronic myeloid leukemia 0.646086957 0.780632411 0.571428571 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Chronic myeloid leukemia -0.582608696 -0.739130435 -0.545173745 kegg kegg NA NA no no no no no no MicroRNAs in cancer Chronic myeloid leukemia 0.420869565 0.820158103 0 kegg kegg NA NA no no no no no no Mismatch repair Chronic myeloid leukemia -0.519130435 -0.805335968 -0.629343629 kegg kegg NA NA no no no no no no mRNA surveillance pathway Chronic myeloid leukemia 0.534782609 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Chronic myeloid leukemia -0.416521739 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Chronic myeloid leukemia 0 -0.428853755 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Chronic myeloid leukemia 0 0.437747036 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Chronic myeloid leukemia 0.807826087 0.923913043 0.726126126 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Chronic myeloid leukemia 0.596521739 0.804347826 0.801287001 kegg kegg NA NA no no no no no no Nicotine addiction Chronic myeloid leukemia 0 0 0.677477477 kegg kegg NA NA no up up no no no NOD-like receptor signaling pathway Chronic myeloid leukemia 0 0.650197628 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Chronic myeloid leukemia -0.579130435 -0.781620553 -0.630630631 kegg kegg NA NA no no no no no no Notch signaling pathway Chronic myeloid leukemia 0.429565217 0.48715415 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Chronic myeloid leukemia 0 -0.721343874 -0.479021879 kegg kegg NA NA no no no no no no One carbon pool by folate Chronic myeloid leukemia 0 -0.704545455 0 kegg kegg NA NA no no no no no no Oocyte meiosis Chronic myeloid leukemia 0 -0.682806324 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Chronic myeloid leukemia 0 0.508893281 0.4002574 kegg kegg NA NA no no no no no no Other glycan degradation Chronic myeloid leukemia 0 0.445652174 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Chronic myeloid leukemia 0.422608696 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Chronic myeloid leukemia -0.551304348 -0.414031621 -0.465894466 kegg kegg NA NA no no no no no no p53 signaling pathway Chronic myeloid leukemia 0.407826087 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Chronic myeloid leukemia 0.502608696 0.617588933 0.421106821 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Chronic myeloid leukemia -0.620869565 -0.589920949 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Chronic myeloid leukemia -0.562608696 -0.709486166 -0.491891892 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Chronic myeloid leukemia 0 0.624505929 0.412612613 kegg kegg NA NA no up up no no no Phototransduction Chronic myeloid leukemia 0 -0.718379447 -0.582496782 kegg kegg NA NA no no no no no no Platelet activation Chronic myeloid leukemia -0.51826087 -0.501976285 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Chronic myeloid leukemia 0 0.591897233 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Chronic myeloid leukemia -0.604347826 -0.752964427 -0.702187902 kegg kegg NA NA no no no no no no Prion disease Chronic myeloid leukemia 0 0 -0.418275418 kegg kegg NA NA no no no no no no Prolactin signaling pathway Chronic myeloid leukemia 0 0.649209486 0.566537967 kegg kegg NA NA no no no no no no Propanoate metabolism Chronic myeloid leukemia -0.508695652 -0.727272727 -0.566795367 kegg kegg NA NA no no no no no no Prostate cancer Chronic myeloid leukemia 0.886086957 0.977272727 0.833719434 kegg kegg NA NA no no no no no no Proteasome Chronic myeloid leukemia 0 -0.566205534 0 kegg kegg NA NA no no no no no no Protein export Chronic myeloid leukemia 0 -0.423913043 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Chronic myeloid leukemia -0.460869565 -0.619565217 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Chronic myeloid leukemia -0.536521739 -0.691699605 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Chronic myeloid leukemia -0.523478261 -0.717391304 -0.561647362 kegg kegg NA NA no no no no no no Ras signaling pathway Chronic myeloid leukemia 0 -0.486166008 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Chronic myeloid leukemia -0.492173913 -0.684782609 -0.673873874 kegg kegg NA NA no no no no no no Relaxin signaling pathway Chronic myeloid leukemia 0.673913043 0.813241107 0.649420849 kegg kegg NA NA no no no no no no Renal cell carcinoma Chronic myeloid leukemia 0.58173913 0 0 kegg kegg NA NA no no no no no no Renin secretion Chronic myeloid leukemia -0.494782609 -0.593873518 0 kegg kegg NA NA no no no no no no Retinol metabolism Chronic myeloid leukemia -0.646956522 -0.736166008 -0.433204633 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Chronic myeloid leukemia 0 -0.471343874 0 kegg kegg NA NA no no up no no no Ribosome biogenesis in eukaryotes Chronic myeloid leukemia 0 -0.419960474 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Chronic myeloid leukemia 0.67826087 0.808300395 0.773230373 kegg kegg NA NA no no no no no no RNA degradation Chronic myeloid leukemia 0.525217391 0 0 kegg kegg NA NA no no no no no no RNA polymerase Chronic myeloid leukemia 0 -0.423913043 0 kegg kegg NA NA no no no no no no Roseburia Chronic myeloid leukemia -0.499130435 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Salivary secretion Chronic myeloid leukemia -0.42173913 -0.449604743 0 kegg kegg NA NA no no no no no no Salmonella infection Chronic myeloid leukemia 0 0 -0.432432432 kegg kegg NA NA no no no no no no Sarcina Chronic myeloid leukemia 0 0.444554224 0 Genus kegg 0.0703 NA no no no no no no Serotonergic synapse Chronic myeloid leukemia -0.412173913 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Chronic myeloid leukemia 0.647826087 0.510869565 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Chronic myeloid leukemia 0 0.523715415 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Chronic myeloid leukemia 0.433913043 0.56916996 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Chronic myeloid leukemia 0.535652174 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Chronic myeloid leukemia 0 -0.833003953 -0.512226512 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Chronic myeloid leukemia -0.706956522 -0.831027668 0 kegg kegg NA NA no no no no no no Sulfur metabolism Chronic myeloid leukemia 0 -0.518774704 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Chronic myeloid leukemia -0.494782609 -0.730237154 -0.52046332 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Chronic myeloid leukemia 0.528695652 0.654150198 0 kegg kegg NA NA no no no no no no Taste transduction Chronic myeloid leukemia 0 -0.615612648 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Chronic myeloid leukemia 0.406956522 0.533596838 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Chronic myeloid leukemia 0 -0.464426877 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Chronic myeloid leukemia 0 -0.453557312 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Chronic myeloid leukemia 0.473913043 0.53458498 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Chronic myeloid leukemia 0.532173913 0.613636364 0 kegg kegg NA NA no no no no no no Thermogenesis Chronic myeloid leukemia 0 0 -0.412870013 kegg kegg NA NA no no no no no no Thiamine metabolism Chronic myeloid leukemia 0 -0.576086957 0 kegg kegg NA NA no no no no no no Tight junction Chronic myeloid leukemia -0.409565217 -0.53458498 -0.586357786 kegg kegg NA NA no no no no no no TNF signaling pathway Chronic myeloid leukemia 0.864347826 0.936758893 0.847876448 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Chronic myeloid leukemia 0.617391304 0.750988142 0.636293436 yes kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Chronic myeloid leukemia 0.566086957 0.678853755 0.60978121 kegg kegg NA NA no no no no no no Tryptophan metabolism Chronic myeloid leukemia -0.563478261 -0.787549407 -0.465894466 kegg kegg NA NA no up no no no no Type II diabetes mellitus Chronic myeloid leukemia 0.680869565 0.662055336 0.490604891 kegg kegg NA NA no no no no no no Tyrosine metabolism Chronic myeloid leukemia -0.787826087 -0.889328063 -0.737451737 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Chronic myeloid leukemia -0.534782609 -0.741106719 -0.41029601 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Chronic myeloid leukemia -0.48 -0.73715415 -0.655598456 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Chronic myeloid leukemia 0 -0.491106719 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Chronic myeloid leukemia 0.571304348 0.618577075 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Chronic myeloid leukemia -0.439130435 -0.472332016 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Chronic myeloid leukemia 0 0.649209486 0 kegg kegg NA NA no no no no no no ABC transporters Circadian entrainment -0.597391304 0 0 kegg kegg NA NA no up up no up up Adherens junction Circadian entrainment 0 0.64229249 0 kegg kegg NA NA no no no no up up Adrenergic signaling in cardiomyocytes Circadian entrainment 0.607826087 0.518774704 0.585585586 kegg kegg NA NA no no up no up up "Alanine, aspartate and glutamate metabolism" Circadian entrainment -0.499130435 -0.536561265 0 kegg kegg NA NA no no no no up up alpha-Linolenic acid metabolism Circadian entrainment 0 0 -0.503474903 kegg kegg NA NA no no no no up up AMPK signaling pathway Circadian entrainment 0 0 0.428056628 kegg kegg NA NA no no no no up up Apelin signaling pathway Circadian entrainment 0 0.442687747 0 kegg kegg NA NA no no no no up up Apoptosis Circadian entrainment 0 -0.507905138 0 kegg kegg NA NA no no no no up up Arachidonic acid metabolism Circadian entrainment 0 0.453557312 0.453281853 kegg kegg NA NA no no no no up up Arginine and proline metabolism Circadian entrainment 0 -0.483201581 0 kegg kegg NA NA no up no no up up Arginine biosynthesis Circadian entrainment -0.46 -0.486166008 0 kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism Circadian entrainment 0 0 -0.534620335 kegg kegg NA NA no no no no up up Autophagy - animal Circadian entrainment 0 -0.710474308 -0.538223938 kegg kegg NA NA no no no no up up Autophagy - other Circadian entrainment 0 -0.640316206 0 kegg kegg NA NA no no no no up up B cell receptor signaling pathway Circadian entrainment -0.56 -0.611660079 0 kegg kegg NA NA no no no no up up Biosynthesis of cofactors Circadian entrainment 0 0 0.497039897 kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway Circadian entrainment 0 -0.747035573 0 kegg kegg NA NA no no no no up up Calcium signaling pathway Circadian entrainment 0 0.466403162 0 kegg kegg NA NA no up up no up up Cardiac muscle contraction Circadian entrainment 0 0.552371542 0 kegg kegg NA NA no no up no up up Cell adhesion molecules Circadian entrainment 0 -0.486166008 0 kegg kegg NA NA no no no no up up Cellular senescence Circadian entrainment 0 -0.507905138 0 kegg kegg NA NA no no no no up up Coprococcus Circadian entrainment 0 0 -0.530536072 butyrate-producing Genus kegg 0.612 NA no no no no up up Cytosolic DNA-sensing pathway Circadian entrainment 0 -0.622529644 0 kegg kegg NA NA no no no no up up Drug metabolism - cytochrome P450 Circadian entrainment 0 0.457509881 0 kegg kegg NA NA no no no no up up Drug metabolism - other enzymes Circadian entrainment 0 0.464426877 -0.456885457 kegg kegg NA NA no no no no up up Endocrine resistance Circadian entrainment 0.477391304 0 0.61003861 kegg kegg NA NA no no no no up up Endocytosis Circadian entrainment 0 -0.433794466 0 kegg kegg NA NA no no no no up up ErbB signaling pathway Circadian entrainment 0 -0.530632411 0 kegg kegg NA NA no no no no up up Fatty acid biosynthesis Circadian entrainment 0 -0.471343874 0 kegg kegg NA NA no no no no up up Fatty acid degradation Circadian entrainment 0 -0.485177866 -0.501158301 kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway Circadian entrainment 0 -0.538537549 -0.405920206 kegg kegg NA NA no no no no up up Ferroptosis Circadian entrainment 0.550434783 0 0.433204633 kegg kegg NA NA no no no no up up Focal adhesion Circadian entrainment 0 0.605731225 0 kegg kegg NA NA no up up no up up FoxO signaling pathway Circadian entrainment 0 -0.468379447 0 kegg kegg NA NA no no no no up up Fructose and mannose metabolism Circadian entrainment 0 -0.420948617 -0.454311454 kegg kegg NA NA no no no no up up Galactose metabolism Circadian entrainment 0 -0.424901186 -0.570913771 kegg kegg NA NA no no no no up up Gap junction Circadian entrainment 0.704347826 0 0.753410553 kegg kegg NA NA no no no no up up Glutathione metabolism Circadian entrainment 0 0.577075099 0.565250965 kegg kegg NA NA no no no no up up Glycerolipid metabolism Circadian entrainment -0.707826087 0 -0.582754183 kegg kegg NA NA no no up no up up Glycerophospholipid metabolism Circadian entrainment 0 0 -0.455598456 kegg kegg NA NA no no up no up up "Glycine, serine and threonine metabolism" Circadian entrainment 0 0 0.490862291 kegg kegg NA NA no up no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Circadian entrainment -0.482608696 -0.567193676 -0.438867439 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Circadian entrainment 0 0 -0.466409266 kegg kegg NA NA no no no no up up Glycosaminoglycan degradation Circadian entrainment 0 0 -0.648906049 kegg kegg NA NA no no up no up up Glycosphingolipid biosynthesis - globo and isoglobo series Circadian entrainment 0.430434783 0 0 kegg kegg NA NA no no no no up up Glyoxylate and dicarboxylate metabolism Circadian entrainment -0.590434783 -0.52173913 0 kegg kegg NA NA no no no no up up Hippo signaling pathway Circadian entrainment 0 0.575098814 0 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Circadian entrainment -0.430434783 0 -0.533333333 kegg kegg NA NA no no no no up up Histidine metabolism Circadian entrainment 0 0 -0.402059202 kegg kegg NA NA no no no no up up Inositol phosphate metabolism Circadian entrainment -0.479130435 0 -0.448648649 kegg kegg NA NA no no no no up up JAK-STAT signaling pathway Circadian entrainment 0 -0.614624506 0 kegg kegg NA NA no no no no up up Lachnospira Circadian entrainment 0 0.523350646 0 butyrate-producing Genus kegg 0.279 NA no no no no up up Lysine degradation Circadian entrainment -0.516521739 0 0 kegg kegg NA NA no no no no up up MAPK signaling pathway Circadian entrainment 0 -0.446640316 -0.556499356 kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 Circadian entrainment 0 0.482213439 0 kegg kegg NA NA no no no no up up Mitophagy - animal Circadian entrainment 0.427826087 0 0 kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis Circadian entrainment 0 -0.458498024 0 kegg kegg NA NA no no no no up up Natural killer cell mediated cytotoxicity Circadian entrainment 0 -0.436758893 0 kegg kegg NA NA no no no no up up Necroptosis Circadian entrainment 0.519130435 0 0.451994852 kegg kegg NA NA no no no no up up NF-kappa B signaling pathway Circadian entrainment -0.839130435 -0.707509881 0 kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Circadian entrainment -0.432173913 0 0 kegg kegg NA NA no no no no up up Nitrogen metabolism Circadian entrainment 0 -0.416007905 0 kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Circadian entrainment -0.46 -0.77173913 0 kegg kegg NA NA no no no no up up Notch signaling pathway Circadian entrainment 0 0 -0.455083655 kegg kegg NA NA no no no no up up One carbon pool by folate Circadian entrainment 0 0.466403162 0 kegg kegg NA NA no no no no up up Oscillospira Circadian entrainment 0 -0.481225296 0 LPS-producing Genus kegg 0.62 NA no no no no up up Osteoclast differentiation Circadian entrainment -0.542608696 -0.572134387 0 kegg kegg NA NA no no no no up up Other glycan degradation Circadian entrainment -0.60173913 -0.529644269 -0.532561133 kegg kegg NA NA no no no no up up Oxidative phosphorylation Circadian entrainment 0 0.597826087 0 kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis Circadian entrainment 0 0 -0.416988417 kegg kegg NA NA no no dn no up up Peroxisome Circadian entrainment -0.466086957 -0.506916996 0 kegg kegg NA NA no no no no up up Phenylalanine metabolism Circadian entrainment 0 0.467391304 0 kegg kegg NA NA no no no no up up Platelet activation Circadian entrainment 0.569565217 0.729249012 0.425482625 kegg kegg NA NA no no no no up up Porphyrin and chlorophyll metabolism Circadian entrainment 0 0 0.460746461 kegg kegg NA NA no no no no up up PPAR signaling pathway Circadian entrainment 0 -0.71541502 0 kegg kegg NA NA no no no no up up Proteasome Circadian entrainment 0 0 -0.404890605 kegg kegg NA NA no no no no up up Pyrimidine metabolism Circadian entrainment 0 0.503952569 -0.400772201 kegg kegg NA NA no no no no up up Pyruvate metabolism Circadian entrainment 0 0.42687747 0 kegg kegg NA NA no no no no up up Rap1 signaling pathway Circadian entrainment 0 0.571146245 0 kegg kegg NA NA no no no no up up Ras signaling pathway Circadian entrainment 0 0.515810277 0 yes kegg kegg NA NA no up up no up up Retinol metabolism Circadian entrainment 0 0.419960474 0 kegg kegg NA NA no no no no up up Ribosome Circadian entrainment 0 0.458498024 0 kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway Circadian entrainment -0.512173913 -0.758893281 0 kegg kegg NA NA no no no no up up Sarcina Circadian entrainment 0 -0.422326513 0 Genus kegg 0.0703 NA no no no no up up Selenocompound metabolism Circadian entrainment 0 0 -0.400514801 kegg kegg NA NA no no no no up up SNARE interactions in vesicular transport Circadian entrainment -0.623478261 -0.628458498 0 kegg kegg NA NA no no no no up up Sphingolipid metabolism Circadian entrainment 0 0 -0.456113256 kegg kegg NA NA no no no no up up Sphingolipid signaling pathway Circadian entrainment 0 -0.522727273 0 kegg kegg NA NA no no no no up up Spliceosome Circadian entrainment 0 -0.438735178 0 kegg kegg NA NA no no no no up up Starch and sucrose metabolism Circadian entrainment 0 0 -0.473359073 kegg kegg NA NA no no no no up up Steroid biosynthesis Circadian entrainment 0.49826087 0.47826087 0 kegg kegg NA NA no no no no up up Steroid hormone biosynthesis Circadian entrainment 0 0.516798419 0 kegg kegg NA NA no no no no up up T cell receptor signaling pathway Circadian entrainment 0 -0.847826087 0 kegg kegg NA NA no no no no up up TGF-beta signaling pathway Circadian entrainment 0 0.484189723 0 kegg kegg NA NA no no no no up up Th1 and Th2 cell differentiation Circadian entrainment -0.463478261 -0.630434783 0 kegg kegg NA NA no no no no up up Th17 cell differentiation Circadian entrainment -0.517391304 -0.738142292 0 kegg kegg NA NA no no no no up up Tight junction Circadian entrainment 0 0.548418972 0 kegg kegg NA NA no no no no up up TNF signaling pathway Circadian entrainment 0 -0.722332016 0 kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway Circadian entrainment 0 -0.652173913 0 yes kegg kegg NA NA no no no no up up Tyrosine metabolism Circadian entrainment 0 0.589920949 0 kegg kegg NA NA no no no no up up Ubiquitin mediated proteolysis Circadian entrainment 0.408695652 0 0 kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Circadian entrainment 0.64 0.802371542 0.88030888 kegg kegg NA NA no no no no up up VEGF signaling pathway Circadian entrainment 0 -0.479249012 0 kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor Circadian entrainment 0 0 0.496267696 kegg kegg NA NA no no no no up up 2-Oxocarboxylic acid metabolism Circadian rhythm -0.668695652 0 0 kegg kegg NA NA no no no no no no ABC transporters Circadian rhythm 0 0.494071146 0 kegg kegg NA NA no up up no no no Adherens junction Circadian rhythm -0.493913043 0 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Circadian rhythm 0.67826087 0.515810277 0.539253539 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Circadian rhythm 0 0 -0.572715573 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Circadian rhythm -0.70173913 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Circadian rhythm -0.617391304 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Circadian rhythm 0 0.432806324 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Circadian rhythm 0 0.631422925 0 kegg kegg NA NA no no no no no no Antifolate resistance Circadian rhythm 0 0.511857708 0.409266409 kegg kegg NA NA no no no no no no Antigen processing and presentation Circadian rhythm 0 -0.416996047 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Circadian rhythm 0.445217391 0 0 kegg kegg NA NA no no no no no no Apoptosis Circadian rhythm -0.565217391 -0.485177866 -0.613899614 kegg kegg NA NA no no no no no no Apoptosis - multiple species Circadian rhythm 0 0.519762846 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Circadian rhythm -0.446956522 0 -0.614414414 kegg kegg NA NA no no no no no no Arginine and proline metabolism Circadian rhythm 0 -0.485177866 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Circadian rhythm 0 -0.42687747 -0.661003861 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Circadian rhythm -0.405217391 0 0 kegg kegg NA NA no no no no no no Autophagy - animal Circadian rhythm 0.511304348 0 0 kegg kegg NA NA no no no no no no Autophagy - other Circadian rhythm 0.731304348 0.529644269 0.854568855 kegg kegg NA NA no no no no no no Axon guidance Circadian rhythm 0.647826087 0 0 kegg kegg NA NA no up up no no no Basal transcription factors Circadian rhythm 0.499130435 0.779644269 0.742857143 kegg kegg NA NA no no no no no no Base excision repair Circadian rhythm 0 0.663043478 0.480823681 kegg kegg NA NA no no no no no no beta-Alanine metabolism Circadian rhythm -0.836521739 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Circadian rhythm -0.80173913 -0.731225296 -0.831660232 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Circadian rhythm 0 0.448616601 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Circadian rhythm -0.44173913 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Circadian rhythm -0.627826087 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Circadian rhythm 0.514782609 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Circadian rhythm 0.703478261 0 0.566795367 kegg kegg NA NA no up up no no no cAMP signaling pathway Circadian rhythm 0.760869565 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Circadian rhythm -0.805217391 -0.580039526 -0.696010296 kegg kegg NA NA no no no no no no Cardiac muscle contraction Circadian rhythm 0.620869565 0 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Circadian rhythm -0.564347826 -0.579051383 -0.412355212 kegg kegg NA NA no no no no no no Cell cycle Circadian rhythm 0.411304348 0.799407115 0.813642214 kegg kegg NA NA no no no no no no Cellular senescence Circadian rhythm 0 -0.442687747 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Circadian rhythm 0 -0.752964427 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Circadian rhythm 0 -0.602766798 -0.427799228 kegg kegg NA NA no no no no no no Complement and coagulation cascades Circadian rhythm -0.615652174 -0.70256917 -0.726126126 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Circadian rhythm 0 -0.598814229 -0.41003861 kegg kegg NA NA no no no no no no DNA replication Circadian rhythm 0 0.483201581 0.522007722 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Circadian rhythm -0.670434783 0 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Circadian rhythm 0 0 0.456370656 kegg kegg NA NA no up up no no no Endocrine resistance Circadian rhythm 0 0.504940711 0 kegg kegg NA NA no no no no no no Endocytosis Circadian rhythm 0 -0.600790514 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Circadian rhythm 0.53826087 0 0.63011583 kegg kegg NA NA no no no no no no Ether lipid metabolism Circadian rhythm 0.55826087 0.561264822 0.511454311 kegg kegg NA NA no no no no no no Fanconi anemia pathway Circadian rhythm 0 0.644268775 0.598198198 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Circadian rhythm 0 -0.42687747 0 kegg kegg NA NA no no no no no no Fatty acid degradation Circadian rhythm -0.433043478 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Circadian rhythm -0.682608696 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Circadian rhythm -0.577391304 -0.443675889 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Circadian rhythm -0.410434783 -0.745059289 -0.718918919 kegg kegg NA NA no no no no no no Ferroptosis Circadian rhythm 0 0 -0.414929215 kegg kegg NA NA no no no no no no Focal adhesion Circadian rhythm -0.534782609 0 0 kegg kegg NA NA no up up no no no Folate biosynthesis Circadian rhythm 0 0.467391304 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Circadian rhythm -0.728695652 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Circadian rhythm -0.822608696 0 0 kegg kegg NA NA no no no no no no Gap junction Circadian rhythm 0 0 -0.413899614 kegg kegg NA NA no no no no no no Glutathione metabolism Circadian rhythm 0 0 -0.497297297 kegg kegg NA NA no no no no no no Glycerolipid metabolism Circadian rhythm 0 0 0.593050193 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Circadian rhythm 0 0.454545455 0.689060489 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Circadian rhythm -0.706086957 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Circadian rhythm -0.513913043 0 0.453796654 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Circadian rhythm 0 0.496047431 0.671814672 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Circadian rhythm 0 -0.5256917 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Circadian rhythm 0 0.485177866 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Circadian rhythm 0.426956522 0 0.537194337 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Circadian rhythm 0 0.515810277 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Circadian rhythm 0 -0.456521739 -0.652509653 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Circadian rhythm 0.620869565 0.747035573 0.813384813 kegg kegg NA NA no no no no no no Hippo signaling pathway Circadian rhythm -0.453913043 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Circadian rhythm -0.624347826 0 0 kegg kegg NA NA no no no no no no Homologous recombination Circadian rhythm 0 0.541501976 0.545688546 kegg kegg NA NA no no no no no no IL-17 signaling pathway Circadian rhythm 0 -0.745059289 -0.551608752 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Circadian rhythm 0 0.486166008 0.538738739 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Circadian rhythm -0.447826087 -0.482213439 -0.598455598 kegg kegg NA NA no no no no no no Linoleic acid metabolism Circadian rhythm 0 0 0.46048906 kegg kegg NA NA no no no no no no Lysine degradation Circadian rhythm 0 0.781620553 0.847619048 kegg kegg NA NA no no no no no no Lysosome Circadian rhythm 0 -0.81027668 -0.54028314 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Circadian rhythm 0.553043478 0.712450593 0.862033462 kegg kegg NA NA no no no no no no MAPK signaling pathway Circadian rhythm 0 0 0.422908623 kegg kegg NA NA no no no no no no Mitophagy - animal Circadian rhythm 0.41826087 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Circadian rhythm 0.847826087 0.803359684 0.912741313 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Circadian rhythm 0.413043478 0.58201581 0.638352638 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Circadian rhythm -0.443478261 -0.5256917 0 kegg kegg NA NA no no no no no no Necroptosis Circadian rhythm 0 0 -0.405148005 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Circadian rhythm 0 -0.721343874 -0.595109395 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Circadian rhythm -0.530434783 -0.808300395 -0.852509653 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Circadian rhythm 0 -0.51284585 -0.484169884 kegg kegg NA NA no no no no no no Nitrogen metabolism Circadian rhythm 0 0 -0.52972973 kegg kegg NA NA no no no no no no Non-homologous end-joining Circadian rhythm -0.612173913 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Circadian rhythm 0 0 0.624967825 kegg kegg NA NA no no no no no no Nucleotide excision repair Circadian rhythm 0 0.532608696 0 kegg kegg NA NA no no no no no no One carbon pool by folate Circadian rhythm 0 0.514822134 0.529472329 kegg kegg NA NA no no no no no no Oocyte meiosis Circadian rhythm 0.567826087 0 0.601029601 kegg kegg NA NA no no no no no no Osteoclast differentiation Circadian rhythm 0 -0.563241107 -0.472844273 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Circadian rhythm 0.526086957 0.79743083 0.805920206 kegg kegg NA NA no no no no no no Oxidative phosphorylation Circadian rhythm 0.611304348 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Circadian rhythm 0.570434783 0.5256917 0.57992278 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Circadian rhythm 0 -0.554347826 -0.465894466 kegg kegg NA NA no no dn no no no Pentose phosphate pathway Circadian rhythm -0.609565217 -0.82312253 -0.742342342 kegg kegg NA NA no no no no no no Peroxisome Circadian rhythm 0 -0.464426877 -0.655598456 kegg kegg NA NA no no no no no no Phagosome Circadian rhythm -0.63826087 -0.739130435 -0.681338481 kegg kegg NA NA no no no no no no Phenylalanine metabolism Circadian rhythm -0.680869565 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Circadian rhythm 0.760869565 0.694664032 0.830888031 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Circadian rhythm 0 0 0.418790219 yes kegg kegg NA NA no up up no no no Platelet activation Circadian rhythm -0.527826087 0 -0.501158301 kegg kegg NA NA no no no no no no Platinum drug resistance Circadian rhythm 0 0.625494071 0.514543115 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Circadian rhythm 0 0 -0.423938224 kegg kegg NA NA no no no no no no Protein export Circadian rhythm 0.717391304 0 0.69009009 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Circadian rhythm 0 0.635375494 0 kegg kegg NA NA no no no no no no Purine metabolism Circadian rhythm 0 0.457509881 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Circadian rhythm -0.627826087 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Circadian rhythm -0.409565217 0 -0.510939511 kegg kegg NA NA no no no no no no Ras signaling pathway Circadian rhythm 0.505217391 0 0.75006435 yes kegg kegg NA NA no up up no no no Renin-angiotensin system Circadian rhythm 0 -0.671936759 0 kegg kegg NA NA no no no no no no Retinol metabolism Circadian rhythm -0.497391304 0 0 kegg kegg NA NA no no no no no no Ribosome Circadian rhythm 0.66 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Circadian rhythm 0.430434783 0.757905138 0.748777349 kegg kegg NA NA no no no no no no RNA degradation Circadian rhythm 0.823478261 0.622529644 0.881853282 kegg kegg NA NA no no no no no no RNA polymerase Circadian rhythm 0.56173913 0.743083004 0.567310167 kegg kegg NA NA no no no no no no Selenocompound metabolism Circadian rhythm 0 0.656126482 0.557528958 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Circadian rhythm 0.77826087 0.770750988 0.783268983 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Circadian rhythm 0.609565217 0 0 kegg kegg NA NA no no no no no no Spliceosome Circadian rhythm 0 0.703557312 0.787902188 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Circadian rhythm -0.546956522 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Circadian rhythm -0.47826087 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Circadian rhythm -0.523478261 0 -0.56988417 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Circadian rhythm 0 0.464426877 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Circadian rhythm 0.426086957 0 0.551608752 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Circadian rhythm 0 0.454545455 0.546203346 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Circadian rhythm 0 0.448616601 0.575032175 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Circadian rhythm 0.59826087 0 0.630888031 kegg kegg NA NA no no no no no no Tight junction Circadian rhythm -0.53826087 0 -0.696010296 kegg kegg NA NA no no no no no no TNF signaling pathway Circadian rhythm 0.565217391 0 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Circadian rhythm 0 -0.461462451 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Circadian rhythm -0.648695652 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Circadian rhythm -0.573043478 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Circadian rhythm -0.465217391 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Circadian rhythm 0.428695652 0.451581028 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Circadian rhythm -0.446956522 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Circadian rhythm 0.505217391 0.599802372 0.591248391 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Circadian rhythm 0.512173913 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Circadian rhythm 0.586956522 0 0.520978121 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Circadian rhythm 0 -0.682806324 -0.417760618 kegg kegg NA NA no no no no no no Wnt signaling pathway Circadian rhythm 0.587826087 0.649209486 0.847361647 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Citrate cycle (TCA cycle) 0.692173913 0.785573123 0.436550837 kegg kegg NA NA no no no no no no 1-68 Cloacibacillus 0 0.408673758 0 Genus Genus 0.828 0.933 no no no no no no Eggerthella Clostridium 0.465757046 0 0 Genus Genus 0.912 0.925 no no no no no no 2-Oxocarboxylic acid metabolism Cocaine addiction 0 0 -0.541055341 kegg kegg NA NA no no no no no no ABC transporters Cocaine addiction -0.444347826 0 0 kegg kegg NA NA no up up no no no Adipocytokine signaling pathway Cocaine addiction 0.410434783 0 0.529472329 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Cocaine addiction 0.570434783 0.677865613 0.675933076 kegg kegg NA NA no no up no no no Aldosterone synthesis and secretion Cocaine addiction 0.77826087 0.779644269 0.78018018 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Cocaine addiction -0.52 0 -0.781467181 kegg kegg NA NA no no no no no no Alzheimer disease Cocaine addiction 0 0.491106719 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Cocaine addiction -0.444347826 0 -0.629343629 kegg kegg NA NA no no no no no no AMPK signaling pathway Cocaine addiction 0.45826087 0.640316206 0.417245817 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Cocaine addiction 0.457391304 0.481225296 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Cocaine addiction -0.417391304 -0.485177866 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Cocaine addiction -0.487826087 0 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Cocaine addiction -0.405217391 0 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Cocaine addiction 0 0 -0.702960103 kegg kegg NA NA no no no no no no beta-Alanine metabolism Cocaine addiction -0.422608696 -0.516798419 -0.663320463 kegg kegg NA NA no no no no no no Bile secretion Cocaine addiction 0.796521739 0.779644269 0.718146718 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Cocaine addiction -0.462608696 -0.579051383 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Cocaine addiction -0.452173913 -0.523715415 -0.537194337 kegg kegg NA NA no no no no no no Blautia Cocaine addiction 0 -0.42687747 0 acetate-producing Genus kegg 1.36E-05 NA up dn dn no no no Butanoate metabolism Cocaine addiction 0 0 -0.480566281 kegg kegg NA NA no no no no no no Calcium signaling pathway Cocaine addiction 0.511304348 0.747035573 0.762162162 kegg kegg NA NA no up up no no no cAMP signaling pathway Cocaine addiction 0.449565217 0.425889328 0.827284427 yes kegg kegg NA NA no up up no no no Carbon metabolism Cocaine addiction -0.433913043 -0.729249012 -0.511969112 kegg kegg NA NA no no no no no no Cardiac muscle contraction Cocaine addiction 0 0.484189723 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Cocaine addiction 0 -0.64229249 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Cocaine addiction 0 -0.449604743 0 kegg kegg NA NA no no no no no no Cholesterol metabolism Cocaine addiction 0 -0.496047431 0 yes kegg kegg NA NA no no up no no no Circadian entrainment Cocaine addiction 0.477391304 0 0.656370656 kegg kegg NA NA no up up no no no Circadian rhythm Cocaine addiction 0 0.438735178 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Cocaine addiction -0.431304348 0 -0.617245817 kegg kegg NA NA no no no no no no Clostridium Cocaine addiction 0 -0.511440348 0 Genus kegg 0.925 NA no no no no no no Complement and coagulation cascades Cocaine addiction 0 -0.497035573 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Cocaine addiction 0.94 0.944664032 0.936679537 kegg kegg NA NA no no up no no no Cushing syndrome Cocaine addiction 0.827826087 0.872529644 0.769111969 kegg kegg NA NA no no up no no no Cytokine-cytokine receptor interaction Cocaine addiction 0 -0.419960474 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Cocaine addiction 0 0 0.464092664 kegg kegg NA NA no no no no no no Dopaminergic synapse Cocaine addiction 0.57826087 0.597826087 0.711196911 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Cocaine addiction 0 0 -0.419305019 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Cocaine addiction -0.496521739 0 -0.537966538 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Cocaine addiction 0.769565217 0.773715415 0.749292149 kegg kegg NA NA no no no no no no Endocrine resistance Cocaine addiction 0.734782609 0.837944664 0.692149292 kegg kegg NA NA no no no no no no Endocytosis Cocaine addiction 0 -0.619565217 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Cocaine addiction 0 -0.438735178 -0.472072072 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Cocaine addiction -0.475652174 0 0 kegg kegg NA NA no no no no no no Fatty acid degradation Cocaine addiction -0.709565217 -0.471343874 -0.773230373 kegg kegg NA NA no no no no no no Fatty acid elongation Cocaine addiction -0.434782609 -0.603754941 -0.544658945 kegg kegg NA NA no no no no no no Fatty acid metabolism Cocaine addiction -0.667826087 -0.572134387 -0.712483912 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Cocaine addiction -0.674782609 -0.671936759 0 kegg kegg NA NA no no no no no no Ferroptosis Cocaine addiction 0.57826087 0.545454545 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Cocaine addiction 0 0 -0.497039897 kegg kegg NA NA no no no no no no GABAergic synapse Cocaine addiction -0.427826087 0 0 kegg kegg NA NA no up up no no no Galactose metabolism Cocaine addiction 0 -0.414031621 -0.566537967 kegg kegg NA NA no no no no no no Gap junction Cocaine addiction 0.682608696 0.720355731 0.635263835 kegg kegg NA NA no no no no no no Gastric acid secretion Cocaine addiction 0.429565217 0 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Cocaine addiction 0.528695652 0.618577075 0.549292149 kegg kegg NA NA no no no no no no Glutamatergic synapse Cocaine addiction 0.528695652 0.475296443 0.576576577 kegg kegg NA NA no up up no no no Glutathione metabolism Cocaine addiction 0 0.434782609 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Cocaine addiction 0 0.468379447 0.427284427 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Cocaine addiction 0 0 -0.482625483 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Cocaine addiction 0 0 -0.452767053 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Cocaine addiction 0.479130435 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Cocaine addiction 0 -0.532608696 -0.543629344 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Cocaine addiction 0 0.416996047 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Cocaine addiction -0.506956522 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Cocaine addiction 0.800869565 0.883399209 0.848133848 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Cocaine addiction 0.563478261 0.62944664 0.732303732 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Cocaine addiction 0 -0.520750988 -0.448133848 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Cocaine addiction -0.420869565 0 -0.423423423 kegg kegg NA NA no no no no no no Histidine metabolism Cocaine addiction -0.453043478 -0.428853755 -0.758043758 kegg kegg NA NA no no no no no no Huntington disease Cocaine addiction 0 0.510869565 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Cocaine addiction 0.568695652 0.543478261 0.64015444 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Cocaine addiction 0 0 -0.443758044 kegg kegg NA NA no no no no no no Insulin secretion Cocaine addiction 0.914782609 0.941699605 0.942084942 yes kegg kegg NA NA no up up no no no Long-term depression Cocaine addiction 0.813913043 0.774703557 0.873873874 kegg kegg NA NA no no no no no no Longevity regulating pathway Cocaine addiction 0.488695652 0.463438735 0.414929215 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Cocaine addiction -0.551304348 -0.81027668 -0.475675676 kegg kegg NA NA no no no no no no Lysosome Cocaine addiction 0 -0.56027668 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Cocaine addiction 0.409565217 0 0 kegg kegg NA NA no no no no no no Melanogenesis Cocaine addiction 0.666956522 0.617588933 0.737709138 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Cocaine addiction 0 0 -0.436293436 kegg kegg NA NA no no no no no no Mineral absorption Cocaine addiction 0.719130435 0.78458498 0.451994852 kegg kegg NA NA no no no no no no Mismatch repair Cocaine addiction -0.48 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Cocaine addiction 0.700869565 0.660079051 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Cocaine addiction 0 0.4743083 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Cocaine addiction -0.431304348 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Cocaine addiction 0 -0.5 0 kegg kegg NA NA no no no no no no Necroptosis Cocaine addiction 0.663478261 0.636363636 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Cocaine addiction -0.603478261 -0.731225296 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Cocaine addiction -0.432173913 -0.535573123 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Cocaine addiction -0.590434783 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Cocaine addiction -0.673913043 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Cocaine addiction 0 0.532608696 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Cocaine addiction -0.429565217 -0.526679842 -0.412097812 kegg kegg NA NA no no no no no no Odoribacter Cocaine addiction 0 -0.547797618 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Olfactory transduction Cocaine addiction -0.56173913 -0.519762846 -0.443243243 kegg kegg NA NA no no no no no no Osteoclast differentiation Cocaine addiction -0.542608696 -0.483201581 0 kegg kegg NA NA no no no no no no Other glycan degradation Cocaine addiction 0 0 -0.4996139 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Cocaine addiction 0 0.446640316 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Cocaine addiction 0.684347826 0.818181818 0.73976834 kegg kegg NA NA no up up no no no Oxidative phosphorylation Cocaine addiction 0 0.460474308 0 kegg kegg NA NA no no no no no no Pancreatic secretion Cocaine addiction 0.787826087 0.693675889 0.832689833 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Cocaine addiction -0.546956522 -0.485177866 -0.524581725 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Cocaine addiction 0.67826087 0.744071146 0.689317889 kegg kegg NA NA no no no no no no Parkinson disease Cocaine addiction 0.654782609 0.546442688 0.452252252 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Cocaine addiction 0.653043478 0.556324111 0.422651223 kegg kegg NA NA no no no no no no Pentose phosphate pathway Cocaine addiction 0 -0.564229249 0 kegg kegg NA NA no no no no no no Peroxisome Cocaine addiction -0.757391304 -0.549407115 0 kegg kegg NA NA no no no no no no Phagosome Cocaine addiction 0 -0.612648221 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Cocaine addiction 0 0 0.482625483 kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism Cocaine addiction 0 0.418972332 0 kegg kegg NA NA no no no no no no Prevotella Cocaine addiction 0 0 0.438094835 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Cocaine addiction -0.507826087 -0.542490119 -0.479279279 kegg kegg NA NA no no no no no no Propanoate metabolism Cocaine addiction -0.408695652 0 0 kegg kegg NA NA no no no no no no Proteasome Cocaine addiction 0 0 -0.456885457 kegg kegg NA NA no no no no no no Protein digestion and absorption Cocaine addiction -0.517391304 -0.595849802 0 yes kegg kegg NA NA no up up no no no Purine metabolism Cocaine addiction 0 0.514822134 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Cocaine addiction -0.496521739 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Cocaine addiction 0.692173913 0.853754941 0.764736165 kegg kegg NA NA no no no no no no Relaxin signaling pathway Cocaine addiction 0.583478261 0.476284585 0.83011583 kegg kegg NA NA no no no no no no Renin secretion Cocaine addiction 0.508695652 0.444664032 0.639382239 kegg kegg NA NA no no no no no no Renin-angiotensin system Cocaine addiction -0.503478261 -0.598814229 0 kegg kegg NA NA no no no no no no Retinol metabolism Cocaine addiction -0.550434783 0 -0.66023166 kegg kegg NA NA no no no no no no Ribosome Cocaine addiction 0.470434783 0 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Cocaine addiction 0 0 0.402059202 kegg kegg NA NA no no no no no no Salivary secretion Cocaine addiction 0.484347826 0 0.541055341 kegg kegg NA NA no no no no no no Selenocompound metabolism Cocaine addiction 0 0 -0.488545689 kegg kegg NA NA no no no no no no Serotonergic synapse Cocaine addiction 0.413043478 0.490118577 0.57014157 kegg kegg NA NA no no no no no no Sphingolipid metabolism Cocaine addiction 0 0 -0.494465894 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Cocaine addiction -0.477391304 0 -0.586615187 kegg kegg NA NA no no no no no no Steroid biosynthesis Cocaine addiction 0 0 -0.45045045 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Cocaine addiction 0 0 -0.608751609 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Cocaine addiction 0 -0.551383399 -0.473873874 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Cocaine addiction 0 0 -0.457142857 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Cocaine addiction 0 0 -0.406949807 kegg kegg NA NA no no no no no no Thermogenesis Cocaine addiction 0.450434783 0.438735178 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Cocaine addiction 0.754782609 0.919960474 0.687773488 kegg kegg NA NA no no no no no no Tryptophan metabolism Cocaine addiction -0.52173913 -0.484189723 -0.671042471 kegg kegg NA NA no up no no no no Type I diabetes mellitus Cocaine addiction 0 -0.531620553 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Cocaine addiction 0 0 -0.498326898 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Cocaine addiction -0.409565217 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Cocaine addiction 0.725217391 0.647233202 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Cocaine addiction -0.439130435 0 -0.61981982 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Cocaine addiction 0.587826087 0.418972332 0.599227799 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Cocaine addiction 0.8 0.720355731 0.762934363 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Collecting duct acid secretion 0 0 -0.54980695 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Collecting duct acid secretion 0 0 0.521750322 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Collecting duct acid secretion 0 0 -0.515315315 kegg kegg NA NA no up up no no no Amino sugar and nucleotide sugar metabolism Collecting duct acid secretion 0 0 0.462290862 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Collecting duct acid secretion 0 0.532608696 0.704761905 kegg kegg NA NA no no no no no no Arginine biosynthesis Collecting duct acid secretion 0 0 0.570656371 kegg kegg NA NA no no no no no no Autophagy - other Collecting duct acid secretion -0.420869565 -0.599802372 -0.593050193 kegg kegg NA NA no no no no no no Axon guidance Collecting duct acid secretion 0 0 -0.462548263 kegg kegg NA NA no up up no no no Basal transcription factors Collecting duct acid secretion -0.451304348 0 0 kegg kegg NA NA no no no no no no Base excision repair Collecting duct acid secretion -0.588695652 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Collecting duct acid secretion 0 0.537549407 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Collecting duct acid secretion 0 0 0.538738739 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Collecting duct acid secretion 0 0 0.470527671 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Collecting duct acid secretion 0 0.637351779 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Collecting duct acid secretion 0 0 -0.63011583 kegg kegg NA NA no up up no no no Carbon metabolism Collecting duct acid secretion 0 0.477272727 0.451994852 kegg kegg NA NA no no no no no no Cell cycle Collecting duct acid secretion 0 0 -0.571428571 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Collecting duct acid secretion 0.414782609 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Collecting duct acid secretion 0 -0.591897233 -0.63037323 kegg kegg NA NA no no no no no no Complement and coagulation cascades Collecting duct acid secretion 0 0.446640316 0 kegg kegg NA NA no no no no no no Cushing syndrome Collecting duct acid secretion 0 -0.444664032 -0.544658945 kegg kegg NA NA no no up no no no Cytokine-cytokine receptor interaction Collecting duct acid secretion 0 0.779644269 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Collecting duct acid secretion 0 -0.605731225 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Collecting duct acid secretion 0 0 -0.41029601 kegg kegg NA NA no up no no no no ECM-receptor interaction Collecting duct acid secretion -0.523478261 0 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Collecting duct acid secretion -0.447826087 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Collecting duct acid secretion -0.44173913 -0.548418972 -0.568854569 kegg kegg NA NA no no no no no no Fatty acid elongation Collecting duct acid secretion 0 0.489130435 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Collecting duct acid secretion 0.415652174 0.484189723 0 kegg kegg NA NA no no no no no no Ferroptosis Collecting duct acid secretion 0 0 0.440926641 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Collecting duct acid secretion 0 0 0.417245817 kegg kegg NA NA no no no no no no GABAergic synapse Collecting duct acid secretion 0 0 0.42960103 kegg kegg NA NA no up up no no no Glucagon signaling pathway Collecting duct acid secretion 0 0 -0.574259974 kegg kegg NA NA no no no no no no Glutathione metabolism Collecting duct acid secretion 0 0 0.616988417 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Collecting duct acid secretion 0 0 0.462290862 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - keratan sulfate Collecting duct acid secretion 0 -0.699604743 -0.487773488 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Collecting duct acid secretion 0.470434783 0 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Collecting duct acid secretion 0 0 -0.402316602 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Collecting duct acid secretion -0.405217391 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Collecting duct acid secretion 0 0 0.54980695 kegg kegg NA NA no no no no no no GnRH secretion Collecting duct acid secretion 0 -0.558300395 0 kegg kegg NA NA no up up no no no Hedgehog signaling pathway Collecting duct acid secretion 0 0 -0.573487773 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Collecting duct acid secretion -0.465217391 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Collecting duct acid secretion 0 0 -0.453539254 kegg kegg NA NA no no no no no no Insulin resistance Collecting duct acid secretion 0 0 -0.438352638 kegg kegg NA NA no no no no no no Insulin secretion Collecting duct acid secretion 0 -0.459486166 0 yes kegg kegg NA NA no up up no no no Long-term potentiation Collecting duct acid secretion 0 0 -0.622651223 kegg kegg NA NA no no up no no no Longevity regulating pathway - multiple species Collecting duct acid secretion 0 0.445652174 0 kegg kegg NA NA no no no no no no Lysine degradation Collecting duct acid secretion -0.640869565 -0.662055336 -0.478249678 kegg kegg NA NA no no no no no no Lysosome Collecting duct acid secretion 0.491304348 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Collecting duct acid secretion 0 -0.746047431 -0.514028314 kegg kegg NA NA no no no no no no Melanogenesis Collecting duct acid secretion 0 0 -0.427541828 kegg kegg NA NA no no no no no no mRNA surveillance pathway Collecting duct acid secretion 0 -0.602766798 -0.595109395 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Collecting duct acid secretion -0.453043478 0 -0.518918919 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Collecting duct acid secretion 0.516521739 0.467391304 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Collecting duct acid secretion 0 -0.461462451 -0.492664093 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Collecting duct acid secretion 0.511304348 0.510869565 0.425225225 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Collecting duct acid secretion 0.432173913 0 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Collecting duct acid secretion 0 0 0.525611326 kegg kegg NA NA no no no no no no Non-homologous end-joining Collecting duct acid secretion 0 0.464426877 0 kegg kegg NA NA no no no no no no Olfactory transduction Collecting duct acid secretion 0.588695652 0.66798419 0.45971686 kegg kegg NA NA no no no no no no Oocyte meiosis Collecting duct acid secretion 0 0 -0.554697555 kegg kegg NA NA no no no no no no Other glycan degradation Collecting duct acid secretion 0 -0.416996047 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Collecting duct acid secretion -0.463478261 -0.516798419 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Collecting duct acid secretion 0.535652174 0.497035573 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Collecting duct acid secretion 0 0.453557312 0.476962677 kegg kegg NA NA no no dn no no no Pentose phosphate pathway Collecting duct acid secretion 0 0.448616601 0.631402831 kegg kegg NA NA no no no no no no Peroxisome Collecting duct acid secretion 0 0.427865613 0.523809524 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Collecting duct acid secretion 0 0 -0.454826255 kegg kegg NA NA no no no no no no Phototransduction Collecting duct acid secretion 0 0.446640316 0 kegg kegg NA NA no no no no no no Platinum drug resistance Collecting duct acid secretion -0.44 0 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Collecting duct acid secretion 0 0 0.489317889 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Collecting duct acid secretion 0 0.558300395 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Collecting duct acid secretion -0.447826087 0 -0.534620335 kegg kegg NA NA no no no no no no Protein export Collecting duct acid secretion -0.409565217 0 -0.536679537 kegg kegg NA NA no no no no no no Purine metabolism Collecting duct acid secretion 0 0 0.421879022 kegg kegg NA NA no no no no no no Ras signaling pathway Collecting duct acid secretion 0 0 -0.423166023 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Collecting duct acid secretion 0 0.598814229 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Collecting duct acid secretion 0.459130435 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Collecting duct acid secretion -0.626086957 0 -0.451737452 kegg kegg NA NA no no no no no no RNA degradation Collecting duct acid secretion 0 -0.436758893 -0.608751609 kegg kegg NA NA no no no no no no RNA polymerase Collecting duct acid secretion -0.546086957 0 0 kegg kegg NA NA no no no no no no RNA transport Collecting duct acid secretion -0.43826087 0 -0.406177606 kegg kegg NA NA no no no no no no Selenocompound metabolism Collecting duct acid secretion -0.43826087 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Collecting duct acid secretion 0 -0.743083004 -0.594851995 kegg kegg NA NA no no no no no no Spliceosome Collecting duct acid secretion -0.665217391 -0.515810277 -0.589446589 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Collecting duct acid secretion 0 0 0.534877735 kegg kegg NA NA no no no no no no Steroid biosynthesis Collecting duct acid secretion 0 0.435770751 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Collecting duct acid secretion 0 0.456521739 0 kegg kegg NA NA no no no no no no Sulfur metabolism Collecting duct acid secretion 0 0 0.735392535 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Collecting duct acid secretion 0.755652174 0.646245059 0.594594595 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Collecting duct acid secretion -0.491304348 -0.470355731 -0.69009009 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Collecting duct acid secretion 0 -0.416996047 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Collecting duct acid secretion 0 0 -0.424195624 kegg kegg NA NA no no no no no no Tight junction Collecting duct acid secretion 0.464347826 0 0.547490347 kegg kegg NA NA no no no no no no TNF signaling pathway Collecting duct acid secretion 0 -0.425889328 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Collecting duct acid secretion 0 0.45256917 0 kegg kegg NA NA no up no no no no Various types of N-glycan biosynthesis Collecting duct acid secretion -0.486086957 0 -0.547490347 kegg kegg NA NA no no no no no no VEGF signaling pathway Collecting duct acid secretion 0 0 -0.485971686 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Collecting duct acid secretion 0 0.652173913 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Collecting duct acid secretion 0 0 -0.565765766 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Colorectal cancer -0.537391304 0 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Colorectal cancer 0.553913043 0 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Colorectal cancer 0 0 0.465637066 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Colorectal cancer 0 0 -0.40952381 kegg kegg NA NA no no no no no no Alcoholism Colorectal cancer 0 -0.57312253 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Colorectal cancer 0.509565217 0 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Colorectal cancer 0.668695652 0.423913043 0.563449163 kegg kegg NA NA no no no no no no Alistipes Colorectal cancer 0 0.574048318 0 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism Colorectal cancer -0.65826087 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Colorectal cancer 0.654782609 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Colorectal cancer -0.728695652 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Colorectal cancer -0.426956522 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Colorectal cancer 0.506956522 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Colorectal cancer 0.654782609 0 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Colorectal cancer 0 -0.440711462 -0.450707851 kegg kegg NA NA no no no no no no Apoptosis - multiple species Colorectal cancer 0 0.416996047 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Colorectal cancer -0.593043478 -0.448616601 -0.611583012 kegg kegg NA NA no no no no no no Arginine biosynthesis Colorectal cancer 0 0 -0.466409266 kegg kegg NA NA no no no no no no Autophagy - animal Colorectal cancer 0 0 0.420849421 kegg kegg NA NA no no no no no no Autophagy - other Colorectal cancer 0.463478261 0.43972332 0.663063063 kegg kegg NA NA no no no no no no Axon guidance Colorectal cancer 0.587826087 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Colorectal cancer 0.463478261 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Colorectal cancer -0.747826087 0 0 kegg kegg NA NA no no no no no no Bile secretion Colorectal cancer 0 0 -0.421879022 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Colorectal cancer -0.77826087 0 -0.54028314 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Colorectal cancer 0 0 -0.43989704 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Colorectal cancer -0.463478261 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Colorectal cancer -0.607826087 0 0 kegg kegg NA NA no no no no no no Butyricimonas Colorectal cancer 0.474571625 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no C-type lectin receptor signaling pathway Colorectal cancer 0.443478261 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Colorectal cancer 0.717391304 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Colorectal cancer 0.727826087 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Colorectal cancer 0.430434783 0.53458498 0.674903475 kegg kegg NA NA no no no no no no Carbon metabolism Colorectal cancer -0.773913043 0 -0.419047619 kegg kegg NA NA no no no no no no Cardiac muscle contraction Colorectal cancer 0.637391304 0 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Colorectal cancer -0.475652174 0 0 kegg kegg NA NA no no no no no no Cell cycle Colorectal cancer 0 0 0.528957529 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Colorectal cancer -0.706956522 -0.528656126 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Colorectal cancer 0.605217391 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Colorectal cancer 0.513913043 0 0.802574003 kegg kegg NA NA no no no no no no Circadian rhythm Colorectal cancer 0.752173913 0.501976285 0.680823681 kegg kegg NA NA no no no no no no Collecting duct acid secretion Colorectal cancer 0 -0.572134387 -0.591505792 kegg kegg NA NA no no no no no no Collinsella Colorectal cancer 0 0 -0.506840774 Genus kegg 0.128 NA no no no no no no Complement and coagulation cascades Colorectal cancer -0.720869565 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Colorectal cancer 0.559130435 0 0 kegg kegg NA NA no no no no no no Cushing syndrome Colorectal cancer 0.427826087 0 0 kegg kegg NA NA no no up no no no Dopaminergic synapse Colorectal cancer 0.493913043 0 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Colorectal cancer -0.509565217 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Colorectal cancer -0.771304348 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Colorectal cancer 0.540869565 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Colorectal cancer 0.72173913 0.611660079 0.897812098 kegg kegg NA NA no no no no no no Ether lipid metabolism Colorectal cancer 0.560869565 0 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Colorectal cancer -0.572173913 0 0 yes kegg kegg NA NA no up up no no no Fatty acid degradation Colorectal cancer -0.477391304 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Colorectal cancer -0.573913043 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Colorectal cancer -0.577391304 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Colorectal cancer 0.612173913 0 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Colorectal cancer 0 0 -0.404890605 kegg kegg NA NA no no no no no no Ferroptosis Colorectal cancer 0 0 -0.61029601 kegg kegg NA NA no no no no no no Folate biosynthesis Colorectal cancer 0 0.523715415 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Colorectal cancer -0.703478261 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Colorectal cancer -0.633043478 0 0 kegg kegg NA NA no no no no no no Gemmiger Colorectal cancer 0 0.512364247 0 butyrate-producing Genus kegg 0.595 NA no no no no no no Glutathione metabolism Colorectal cancer -0.430434783 0 -0.623423423 kegg kegg NA NA no no no no no no Glycerolipid metabolism Colorectal cancer 0 0 0.583783784 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Colorectal cancer 0 0 0.574002574 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Colorectal cancer 0 0 -0.406177606 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Colorectal cancer -0.784347826 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Colorectal cancer 0 0 0.436550837 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Colorectal cancer 0 0.57312253 0.520978121 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Colorectal cancer 0.66173913 0.712450593 0.535135135 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Colorectal cancer 0.65826087 0 0.424967825 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Colorectal cancer -0.43826087 0 -0.457915058 kegg kegg NA NA no no no no no no GnRH secretion Colorectal cancer 0.76 0.527667984 0.829343629 kegg kegg NA NA no up up no no no GnRH signaling pathway Colorectal cancer 0.424347826 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Colorectal cancer 0.586956522 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Colorectal cancer 0.799130435 0.524703557 0.760617761 kegg kegg NA NA no no no no no no Hepatitis B Colorectal cancer 0.444347826 0 0.545173745 kegg kegg NA NA no no no no no no Hepatitis C Colorectal cancer 0.424347826 0 0.426254826 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Colorectal cancer 0 0 0.429343629 kegg kegg NA NA no no no no no no Histidine metabolism Colorectal cancer -0.423478261 0 0 kegg kegg NA NA no no no no no no Huntington disease Colorectal cancer 0.657391304 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Colorectal cancer 0.471304348 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Colorectal cancer 0 0.515810277 0.598455598 kegg kegg NA NA no no no no no no Insulin resistance Colorectal cancer 0.630434783 0 0.516344916 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Colorectal cancer 0 0 -0.558558559 kegg kegg NA NA no no dn no no no Legionellosis Colorectal cancer -0.479130435 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Colorectal cancer -0.536521739 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Colorectal cancer 0.512173913 0 0.601029601 kegg kegg NA NA no no up no no no Lysine degradation Colorectal cancer 0 0.639328063 0.667953668 kegg kegg NA NA no no no no no no Malaria Colorectal cancer 0 0 -0.654826255 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Colorectal cancer 0.690434783 0.742094862 0.662548263 kegg kegg NA NA no no no no no no MAPK signaling pathway Colorectal cancer 0 0 0.805920206 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Colorectal cancer -0.602608696 0 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Colorectal cancer 0 0 0.816216216 kegg kegg NA NA no no no no no no Mineral absorption Colorectal cancer 0 0 -0.57039897 kegg kegg NA NA no no no no no no Mitophagy - animal Colorectal cancer 0 0 -0.554182754 kegg kegg NA NA no no no no no no mRNA surveillance pathway Colorectal cancer 0.775652174 0.456521739 0.636808237 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Colorectal cancer 0 0 0.448391248 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Colorectal cancer -0.48 0 0 kegg kegg NA NA no no no no no no Necroptosis Colorectal cancer 0 0 -0.602316602 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Colorectal cancer 0.654782609 0 0.509137709 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Colorectal cancer -0.473043478 0 -0.458429858 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Colorectal cancer 0.690434783 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Colorectal cancer -0.599130435 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Colorectal cancer 0.593913043 0.435770751 0.696267696 kegg kegg NA NA no no no no no no Olfactory transduction Colorectal cancer 0 -0.494071146 0 kegg kegg NA NA no no no no no no Other glycan degradation Colorectal cancer 0 0 0.49034749 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Colorectal cancer 0.468695652 0.514822134 0.625997426 kegg kegg NA NA no no no no no no Oxidative phosphorylation Colorectal cancer 0.603478261 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Colorectal cancer 0 0 -0.402574003 kegg kegg NA NA no no no no no no Pancreatic secretion Colorectal cancer 0.449565217 0 0 kegg kegg NA NA no no no no no no Parabacteroides Colorectal cancer -0.42173913 0 0 Genus kegg 4.19E-05 NA no up up no no no "Parathyroid hormone synthesis, secretion and action" Colorectal cancer 0.515652174 0 0 kegg kegg NA NA no no no no no no Parkinson disease Colorectal cancer 0.510434783 0 -0.477220077 kegg kegg NA NA no no no no no no Pathways in cancer Colorectal cancer 0.74 0 0.426769627 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Colorectal cancer 0.505217391 0 -0.471557272 kegg kegg NA NA no no no no no no Pentose phosphate pathway Colorectal cancer -0.487826087 0 -0.43989704 kegg kegg NA NA no no no no no no Peroxisome Colorectal cancer -0.445217391 0 -0.564993565 kegg kegg NA NA no no no no no no Pertussis Colorectal cancer -0.457391304 0 0 kegg kegg NA NA no no dn no no no Phagosome Colorectal cancer -0.540869565 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Colorectal cancer -0.460869565 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Colorectal cancer 0.787826087 0.493083004 0.742857143 kegg kegg NA NA no no no no no no Platinum drug resistance Colorectal cancer 0 0.520750988 0.402316602 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Colorectal cancer 0 0 -0.488030888 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Colorectal cancer -0.416521739 0 0 kegg kegg NA NA no no no no no no Prion disease Colorectal cancer 0.573913043 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Colorectal cancer 0 0.481225296 0.687773488 kegg kegg NA NA no no no no no no Prolactin signaling pathway Colorectal cancer 0.539130435 0 0.47001287 kegg kegg NA NA no no no no no no Propanoate metabolism Colorectal cancer -0.451304348 0 0 kegg kegg NA NA no no no no no no Protein export Colorectal cancer 0.506086957 0 0 kegg kegg NA NA no no no no no no Purine metabolism Colorectal cancer 0 0 -0.501673102 kegg kegg NA NA no no no no no no Pyrimidine metabolism Colorectal cancer -0.707826087 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Colorectal cancer 0 0 -0.414157014 kegg kegg NA NA no no no no no no Ras signaling pathway Colorectal cancer 0.415652174 0 0.572715573 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Colorectal cancer -0.417391304 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Colorectal cancer 0.562608696 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Colorectal cancer -0.612173913 0 0 kegg kegg NA NA no no no no no no Ribosome Colorectal cancer 0.562608696 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Colorectal cancer 0 0 0.425225225 kegg kegg NA NA no no no no no no RNA degradation Colorectal cancer 0.80173913 0.424901186 0.617760618 kegg kegg NA NA no no no no no no Salmonella infection Colorectal cancer -0.412173913 0 0 kegg kegg NA NA no no no no no no Shigellosis Colorectal cancer 0 0 -0.643758044 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Colorectal cancer 0.886086957 0.752964427 0.842213642 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Colorectal cancer 0.625217391 0 0.686743887 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Colorectal cancer 0.592173913 0.596837945 0.515315315 kegg kegg NA NA no no no no no no Spliceosome Colorectal cancer 0 0.442687747 0.516859717 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Colorectal cancer -0.500869565 0 -0.451994852 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Colorectal cancer -0.546086957 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Colorectal cancer -0.602608696 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Colorectal cancer -0.59826087 0 -0.616473616 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Colorectal cancer 0 -0.43083004 0 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Colorectal cancer 0 0 0.492921493 kegg kegg NA NA no no no no no no Taste transduction Colorectal cancer 0 0 0.587902188 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Colorectal cancer 0 0 0.451480051 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Colorectal cancer 0.655652174 0 0.607979408 kegg kegg NA NA no no no no no no Thermogenesis Colorectal cancer 0.64173913 0 0 kegg kegg NA NA no no no no no no Tight junction Colorectal cancer 0 0 -0.498584299 kegg kegg NA NA no no no no no no TNF signaling pathway Colorectal cancer 0.49826087 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Colorectal cancer -0.587826087 0 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Colorectal cancer 0.560869565 0.463438735 0.559073359 kegg kegg NA NA no no no no no no Tyrosine metabolism Colorectal cancer -0.562608696 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Colorectal cancer -0.486086957 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Colorectal cancer 0 0 -0.55958816 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Colorectal cancer -0.489565217 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Colorectal cancer 0 0.444664032 0.439124839 kegg kegg NA NA no no no no no no VEGF signaling pathway Colorectal cancer 0.757391304 0 0.793050193 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Colorectal cancer 0 -0.475296443 -0.451737452 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Colorectal cancer 0.688695652 0 0.405920206 kegg kegg NA NA no no no no no no Wnt signaling pathway Colorectal cancer 0.794782609 0.46541502 0.760875161 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Complement and coagulation cascades 0 -0.610671937 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Complement and coagulation cascades -0.457391304 -0.736166008 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Complement and coagulation cascades 0.426956522 0.696640316 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Complement and coagulation cascades 0.607826087 0.548418972 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Complement and coagulation cascades 0.473913043 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Complement and coagulation cascades 0 -0.603754941 -0.404633205 kegg kegg NA NA no no no no no no AMPK signaling pathway Complement and coagulation cascades 0 -0.611660079 0 kegg kegg NA NA no no no no no no Antifolate resistance Complement and coagulation cascades 0 0 -0.425482625 kegg kegg NA NA no no no no no no Apelin signaling pathway Complement and coagulation cascades -0.475652174 -0.548418972 -0.448648649 kegg kegg NA NA no no no no no no Apoptosis Complement and coagulation cascades 0.553913043 0.626482213 0.620849421 kegg kegg NA NA no no no no no no Arginine and proline metabolism Complement and coagulation cascades 0.420869565 0.732213439 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Complement and coagulation cascades 0.524347826 0.739130435 0.492149292 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Complement and coagulation cascades 0 -0.451581028 0 kegg kegg NA NA no no no no no no Autophagy - animal Complement and coagulation cascades 0 0.432806324 0 kegg kegg NA NA no no no no no no Autophagy - other Complement and coagulation cascades -0.406956522 0 -0.523552124 kegg kegg NA NA no no no no no no Basal transcription factors Complement and coagulation cascades -0.600869565 -0.661067194 -0.655855856 kegg kegg NA NA no no no no no no Base excision repair Complement and coagulation cascades 0 -0.543478261 -0.451480051 kegg kegg NA NA no no no no no no beta-Alanine metabolism Complement and coagulation cascades 0.510434783 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Complement and coagulation cascades 0.843478261 0.849802372 0.726126126 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Complement and coagulation cascades 0 -0.609683794 0 kegg kegg NA NA no no no no no no Butanoate metabolism Complement and coagulation cascades 0 -0.488142292 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Complement and coagulation cascades -0.56 -0.494071146 -0.457400257 kegg kegg NA NA no up up no no no cAMP signaling pathway Complement and coagulation cascades -0.52173913 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Complement and coagulation cascades 0.650434783 0 0.624195624 kegg kegg NA NA no no no no no no Cardiac muscle contraction Complement and coagulation cascades -0.500869565 -0.643280632 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Complement and coagulation cascades 0.676521739 0.627470356 0.475933076 kegg kegg NA NA no no no no no no Cell cycle Complement and coagulation cascades -0.52173913 -0.751976285 -0.681853282 kegg kegg NA NA no no no no no no Cellular senescence Complement and coagulation cascades 0.610434783 0.586956522 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Complement and coagulation cascades 0 0.860671937 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Complement and coagulation cascades 0 0.781620553 0.613127413 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Complement and coagulation cascades 0 -0.463438735 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Complement and coagulation cascades 0 -0.43972332 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Complement and coagulation cascades 0 0.662055336 0.547747748 kegg kegg NA NA no no no no no no DNA replication Complement and coagulation cascades 0 -0.632411067 -0.483397683 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Complement and coagulation cascades 0 -0.517786561 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Complement and coagulation cascades 0.50173913 -0.428853755 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Complement and coagulation cascades -0.48 -0.540513834 -0.462033462 kegg kegg NA NA no no no no no no Endocrine resistance Complement and coagulation cascades -0.543478261 0 0 kegg kegg NA NA no no no no no no Endocytosis Complement and coagulation cascades 0.727826087 0.648221344 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Complement and coagulation cascades -0.726086957 -0.747035573 -0.491634492 kegg kegg NA NA no no no no no no Fanconi anemia pathway Complement and coagulation cascades 0 -0.596837945 -0.569369369 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Complement and coagulation cascades 0.443478261 0.756916996 0 kegg kegg NA NA no no no no no no Fatty acid degradation Complement and coagulation cascades 0.506086957 0.535573123 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Complement and coagulation cascades 0.531304348 0.677865613 0 kegg kegg NA NA no no no no no no Folate biosynthesis Complement and coagulation cascades 0 -0.662055336 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Complement and coagulation cascades 0.565217391 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Complement and coagulation cascades 0.490434783 0.53458498 0 kegg kegg NA NA no no no no no no Gap junction Complement and coagulation cascades 0 0 0.412612613 kegg kegg NA NA no no no no no no Glutathione metabolism Complement and coagulation cascades 0 -0.464426877 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Complement and coagulation cascades 0 0 -0.516859717 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Complement and coagulation cascades 0 0 -0.66023166 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Complement and coagulation cascades 0 -0.519762846 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Complement and coagulation cascades 0.6 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Complement and coagulation cascades 0.453913043 0.45256917 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Complement and coagulation cascades 0 -0.459486166 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Complement and coagulation cascades -0.491304348 -0.493083004 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Complement and coagulation cascades 0 0.516798419 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Complement and coagulation cascades -0.417391304 -0.464426877 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Complement and coagulation cascades -0.514782609 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Complement and coagulation cascades 0 -0.517786561 -0.445045045 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Complement and coagulation cascades 0.494782609 0.759881423 0.501158301 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Complement and coagulation cascades -0.609565217 -0.645256917 -0.729214929 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Complement and coagulation cascades 0 0.489130435 0 kegg kegg NA NA no no no no no no Homologous recombination Complement and coagulation cascades 0 -0.418972332 -0.531788932 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Complement and coagulation cascades 0 0 -0.518146718 kegg kegg NA NA no no no no no no Lysine degradation Complement and coagulation cascades 0 -0.631422925 -0.72998713 kegg kegg NA NA no no no no no no Lysosome Complement and coagulation cascades 0 0.777667984 0.498841699 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Complement and coagulation cascades -0.526956522 -0.587944664 -0.67027027 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Complement and coagulation cascades 0 -0.431818182 0 kegg kegg NA NA no no no no no no Mismatch repair Complement and coagulation cascades 0 -0.427865613 0 kegg kegg NA NA no no no no no no Mitophagy - animal Complement and coagulation cascades -0.444347826 -0.59486166 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Complement and coagulation cascades -0.811304348 -0.864624506 -0.825225225 kegg kegg NA NA no no no no no no mTOR signaling pathway Complement and coagulation cascades 0 -0.550395257 -0.477220077 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Complement and coagulation cascades -0.505217391 -0.779644269 -0.436036036 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Complement and coagulation cascades 0 0.817193676 0.675160875 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Complement and coagulation cascades 0 0.440711462 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Complement and coagulation cascades 0.56 0.795454545 0.452509653 kegg kegg NA NA no no no no no no Nitrogen metabolism Complement and coagulation cascades 0.656521739 0.740118577 0.419047619 kegg kegg NA NA no no no no no no Notch signaling pathway Complement and coagulation cascades -0.411304348 0 -0.43011583 kegg kegg NA NA no no no no no no Nucleotide excision repair Complement and coagulation cascades 0 -0.588932806 -0.404375804 kegg kegg NA NA no no no no no no One carbon pool by folate Complement and coagulation cascades 0 -0.617588933 -0.542599743 kegg kegg NA NA no no no no no no Oocyte meiosis Complement and coagulation cascades -0.545217391 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Complement and coagulation cascades 0.494782609 0.781620553 0.510939511 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Complement and coagulation cascades -0.589565217 -0.566205534 -0.697039897 kegg kegg NA NA no no no no no no Oxidative phosphorylation Complement and coagulation cascades -0.546956522 -0.621541502 0 kegg kegg NA NA no no no no no no p53 signaling pathway Complement and coagulation cascades -0.43826087 0 -0.617503218 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Complement and coagulation cascades 0.470434783 0.792490119 0 kegg kegg NA NA no no dn no no no Parabacteroides Complement and coagulation cascades 0 0 0.453053608 Genus kegg 4.19E-05 NA no up up no no no Pentose and glucuronate interconversions Complement and coagulation cascades 0 -0.690711462 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Complement and coagulation cascades 0.733913043 0.904150198 0.585328185 kegg kegg NA NA no no no no no no Peroxisome Complement and coagulation cascades 0.474782609 0.766798419 0 kegg kegg NA NA no no no no no no Phagosome Complement and coagulation cascades 0.74173913 0.779644269 0.630888031 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Complement and coagulation cascades -0.732173913 -0.438735178 -0.708365508 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Complement and coagulation cascades 0 0.418972332 0 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Complement and coagulation cascades 0 0 -0.432947233 yes kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism Complement and coagulation cascades 0 -0.497035573 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Complement and coagulation cascades 0.466086957 0.627470356 0.472329472 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Complement and coagulation cascades 0 0 0.452767053 kegg kegg NA NA no no no no no no Protein export Complement and coagulation cascades -0.76 -0.64229249 -0.610553411 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Complement and coagulation cascades 0 -0.839920949 0 kegg kegg NA NA no no no no no no Purine metabolism Complement and coagulation cascades 0 -0.652173913 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Complement and coagulation cascades 0.419130435 -0.482213439 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Complement and coagulation cascades 0 -0.529644269 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Complement and coagulation cascades 0 0 0.510939511 kegg kegg NA NA no no no no no no Ras signaling pathway Complement and coagulation cascades 0 -0.459486166 -0.427799228 yes kegg kegg NA NA no up up no no no Ribosome Complement and coagulation cascades -0.726086957 -0.511857708 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Complement and coagulation cascades -0.56 -0.745059289 -0.688803089 kegg kegg NA NA no no no no no no RNA degradation Complement and coagulation cascades -0.825217391 -0.849802372 -0.746203346 kegg kegg NA NA no no no no no no RNA polymerase Complement and coagulation cascades -0.532173913 -0.852766798 -0.536422136 kegg kegg NA NA no no no no no no RNA transport Complement and coagulation cascades 0 -0.504940711 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Complement and coagulation cascades 0 0 -0.556241956 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Complement and coagulation cascades -0.512173913 0 -0.536936937 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Complement and coagulation cascades 0 0.492094862 0 kegg kegg NA NA no no no no no no Spliceosome Complement and coagulation cascades 0 -0.449604743 -0.693436293 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Complement and coagulation cascades 0.644347826 0.718379447 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Complement and coagulation cascades -0.555652174 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Complement and coagulation cascades 0 -0.462450593 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Complement and coagulation cascades 0 0 -0.549292149 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Complement and coagulation cascades -0.497391304 0 -0.435263835 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Complement and coagulation cascades -0.708695652 -0.473320158 0 kegg kegg NA NA no no no no no no Thiamine metabolism Complement and coagulation cascades 0 -0.468379447 0 kegg kegg NA NA no no no no no no Tight junction Complement and coagulation cascades 0 0 0.506048906 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Complement and coagulation cascades 0 -0.43972332 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Complement and coagulation cascades -0.552173913 -0.706521739 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Complement and coagulation cascades 0 -0.524703557 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Complement and coagulation cascades 0 -0.636363636 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Complement and coagulation cascades -0.466086957 -0.463438735 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Complement and coagulation cascades 0 0.666996047 0.644015444 kegg kegg NA NA no no no no no no Wnt signaling pathway Complement and coagulation cascades -0.680869565 -0.798418972 -0.662033462 kegg kegg NA NA no no no no no no Clostridium Coprobacillus 0.445005021 0 0 Genus Genus 0.925 0.289 no no no no no no Actinomyces Coprococcus 0 0.474174387 0 butyrate-producing Genus Genus 0.621 0.612 no no no no no no ABC transporters Coronavirus disease - COVID-19 0 -0.526679842 0 kegg kegg NA NA no up up no no no Adherens junction Coronavirus disease - COVID-19 0 0.56027668 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Coronavirus disease - COVID-19 0.602608696 0.687747036 0 kegg kegg NA NA no no up no no no African trypanosomiasis Coronavirus disease - COVID-19 0 -0.592885375 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Coronavirus disease - COVID-19 0 -0.769762846 0 kegg kegg NA NA no no no no no no Akkermansia Coronavirus disease - COVID-19 -0.471598474 0 0 acetate-producing Genus kegg 0.23 NA no no no no no no "Alanine, aspartate and glutamate metabolism" Coronavirus disease - COVID-19 -0.544347826 -0.657114625 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Coronavirus disease - COVID-19 0.549565217 0.671936759 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Coronavirus disease - COVID-19 0 0 -0.553667954 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Coronavirus disease - COVID-19 -0.512173913 -0.811264822 0 kegg kegg NA NA no no no no no no Alzheimer disease Coronavirus disease - COVID-19 0.706956522 0.881422925 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Coronavirus disease - COVID-19 -0.53826087 -0.431818182 0 kegg kegg NA NA no no no no no no Amoebiasis Coronavirus disease - COVID-19 0 -0.624505929 -0.407464607 kegg kegg NA NA no no no no no no Amphetamine addiction Coronavirus disease - COVID-19 0.57826087 0.630434783 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Coronavirus disease - COVID-19 0.744347826 0.811264822 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Coronavirus disease - COVID-19 0.710434783 0.919960474 0.838352638 kegg kegg NA NA no no no no no no Apoptosis Coronavirus disease - COVID-19 -0.64173913 -0.616600791 -0.441441441 kegg kegg NA NA no no no no no no Apoptosis - multiple species Coronavirus disease - COVID-19 0 -0.535573123 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Coronavirus disease - COVID-19 -0.427826087 -0.68083004 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Coronavirus disease - COVID-19 -0.615652174 -0.599802372 0 kegg kegg NA NA no no no no no no Autophagy - animal Coronavirus disease - COVID-19 0 -0.652173913 -0.427284427 kegg kegg NA NA no no no no no no Autophagy - other Coronavirus disease - COVID-19 0.462608696 0 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Coronavirus disease - COVID-19 0 -0.586956522 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Coronavirus disease - COVID-19 -0.434782609 0 0 kegg kegg NA NA no no no no no no Bacteroides Coronavirus disease - COVID-19 -0.426086957 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Coronavirus disease - COVID-19 0.428695652 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Coronavirus disease - COVID-19 -0.606956522 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Coronavirus disease - COVID-19 -0.775652174 -0.486166008 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Coronavirus disease - COVID-19 -0.519130435 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Coronavirus disease - COVID-19 0 0.431818182 0.535907336 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Coronavirus disease - COVID-19 0 -0.540513834 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Coronavirus disease - COVID-19 0.586086957 0.606719368 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Coronavirus disease - COVID-19 0.557391304 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Coronavirus disease - COVID-19 0 -0.472332016 -0.452509653 kegg kegg NA NA no no no no no no Carbon metabolism Coronavirus disease - COVID-19 -0.633043478 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Coronavirus disease - COVID-19 0.64 0.835968379 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Coronavirus disease - COVID-19 -0.530434783 0 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Coronavirus disease - COVID-19 0 -0.517786561 0 kegg kegg NA NA no no no no no no Chagas disease Coronavirus disease - COVID-19 0 -0.529644269 0 kegg kegg NA NA no no no no no no Cholinergic synapse Coronavirus disease - COVID-19 0 0 -0.406177606 kegg kegg NA NA no no no no no no Circadian entrainment Coronavirus disease - COVID-19 0 0.440711462 0 kegg kegg NA NA no up up no no no Circadian rhythm Coronavirus disease - COVID-19 0.664347826 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Coronavirus disease - COVID-19 0 0.468379447 0 kegg kegg NA NA no no no no no no Cocaine addiction Coronavirus disease - COVID-19 0.46173913 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Coronavirus disease - COVID-19 -0.711304348 -0.495059289 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Coronavirus disease - COVID-19 0.428695652 0 0 kegg kegg NA NA no no up no no no Cushing syndrome Coronavirus disease - COVID-19 0.506086957 0 0 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Coronavirus disease - COVID-19 0 0.649209486 0.542084942 kegg kegg NA NA no no no no no no DNA replication Coronavirus disease - COVID-19 0 0.425889328 0.435263835 kegg kegg NA NA no no no no no no Dopaminergic synapse Coronavirus disease - COVID-19 0.542608696 0.590909091 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Coronavirus disease - COVID-19 0 0.533596838 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Coronavirus disease - COVID-19 0 0.588932806 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Coronavirus disease - COVID-19 0.712173913 0.897233202 0.816731017 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Coronavirus disease - COVID-19 0.423478261 0.673913043 0 kegg kegg NA NA no no no no no no Endocytosis Coronavirus disease - COVID-19 -0.490434783 0 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Coronavirus disease - COVID-19 0 -0.497035573 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Coronavirus disease - COVID-19 0 -0.427865613 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Coronavirus disease - COVID-19 0.68 0 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Coronavirus disease - COVID-19 -0.58173913 -0.5256917 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Coronavirus disease - COVID-19 -0.492173913 -0.690711462 0 kegg kegg NA NA no no no no no no Fatty acid degradation Coronavirus disease - COVID-19 -0.616521739 -0.68972332 0 kegg kegg NA NA no no no no no no Fatty acid elongation Coronavirus disease - COVID-19 -0.577391304 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Coronavirus disease - COVID-19 -0.744347826 -0.636363636 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Coronavirus disease - COVID-19 0 -0.706521739 -0.63989704 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Coronavirus disease - COVID-19 -0.797391304 -0.543478261 0 kegg kegg NA NA no no no no no no Focal adhesion Coronavirus disease - COVID-19 0 0.479249012 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Coronavirus disease - COVID-19 0 -0.743083004 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Coronavirus disease - COVID-19 -0.554782609 -0.696640316 0 kegg kegg NA NA no no no no no no GABAergic synapse Coronavirus disease - COVID-19 -0.455652174 -0.505928854 -0.401801802 kegg kegg NA NA no up up no no no Galactose metabolism Coronavirus disease - COVID-19 -0.704347826 -0.754940711 0 kegg kegg NA NA no no no no no no Gastric acid secretion Coronavirus disease - COVID-19 0 0.574110672 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Coronavirus disease - COVID-19 0.542608696 0.665019763 0 kegg kegg NA NA no no no no no no Glutathione metabolism Coronavirus disease - COVID-19 0 0.729249012 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Coronavirus disease - COVID-19 0 -0.718379447 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Coronavirus disease - COVID-19 0 -0.544466403 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Coronavirus disease - COVID-19 -0.49826087 0.627470356 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Coronavirus disease - COVID-19 0 -0.766798419 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Coronavirus disease - COVID-19 0.519130435 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Coronavirus disease - COVID-19 0 -0.528656126 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Coronavirus disease - COVID-19 0 -0.498023715 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Coronavirus disease - COVID-19 -0.637391304 -0.57312253 0 kegg kegg NA NA no no no no no no GnRH secretion Coronavirus disease - COVID-19 0 -0.448616601 0 kegg kegg NA NA no up up no no no GnRH signaling pathway Coronavirus disease - COVID-19 0.425217391 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Coronavirus disease - COVID-19 0.434782609 0 0 kegg kegg NA NA no no no no no no Hepatitis B Coronavirus disease - COVID-19 0 -0.745059289 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Coronavirus disease - COVID-19 0.562608696 0.883399209 0.792535393 kegg kegg NA NA no no no no no no Hippo signaling pathway Coronavirus disease - COVID-19 0 0.516798419 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Coronavirus disease - COVID-19 0 -0.787549407 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Coronavirus disease - COVID-19 -0.471304348 -0.448616601 0 kegg kegg NA NA no no no no no no Huntington disease Coronavirus disease - COVID-19 0.724347826 0.863636364 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Coronavirus disease - COVID-19 -0.435652174 -0.416007905 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Coronavirus disease - COVID-19 0.51826087 0.681818182 0 kegg kegg NA NA no no no no no no Influenza A Coronavirus disease - COVID-19 -0.457391304 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Coronavirus disease - COVID-19 0 -0.553359684 0 kegg kegg NA NA no no no no no no Insulin resistance Coronavirus disease - COVID-19 0.424347826 -0.56916996 0 kegg kegg NA NA no no no no no no Insulin secretion Coronavirus disease - COVID-19 0.420869565 0 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Coronavirus disease - COVID-19 0.708695652 0.895256917 0.777863578 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Coronavirus disease - COVID-19 0 -0.805335968 0 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Coronavirus disease - COVID-19 0.536521739 0.440711462 0.484942085 kegg kegg NA NA no no dn no no no Legionellosis Coronavirus disease - COVID-19 0 0.646245059 0.517631918 kegg kegg NA NA no no no no no no Leishmaniasis Coronavirus disease - COVID-19 0 0.584980237 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Coronavirus disease - COVID-19 -0.405217391 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Coronavirus disease - COVID-19 0.428695652 0.516798419 0 kegg kegg NA NA no no up no no no Lysine degradation Coronavirus disease - COVID-19 0.433043478 0 0 kegg kegg NA NA no no no no no no Malaria Coronavirus disease - COVID-19 0 0 0.417503218 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Coronavirus disease - COVID-19 0.606086957 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Coronavirus disease - COVID-19 0 -0.565217391 0 kegg kegg NA NA no no no no no no Measles Coronavirus disease - COVID-19 0 0 0.529214929 kegg kegg NA NA no no no no no no Melanogenesis Coronavirus disease - COVID-19 0.429565217 0.711462451 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Coronavirus disease - COVID-19 0 0.47826087 0 kegg kegg NA NA no no no no no no Mineral absorption Coronavirus disease - COVID-19 0.584347826 0.519762846 0 kegg kegg NA NA no no no no no no Mitophagy - animal Coronavirus disease - COVID-19 0.766956522 0.757905138 0.541055341 kegg kegg NA NA no no no no no no Morphine addiction Coronavirus disease - COVID-19 0 0.45256917 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Coronavirus disease - COVID-19 0.754782609 0.549407115 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Coronavirus disease - COVID-19 0.712173913 0.889328063 0.783011583 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Coronavirus disease - COVID-19 0 0.497035573 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Coronavirus disease - COVID-19 -0.486956522 0 0 kegg kegg NA NA no no no no no no Necroptosis Coronavirus disease - COVID-19 0.50173913 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Coronavirus disease - COVID-19 -0.509565217 -0.46541502 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Coronavirus disease - COVID-19 0.414782609 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Coronavirus disease - COVID-19 -0.756521739 -0.500988142 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Coronavirus disease - COVID-19 0 -0.733201581 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Coronavirus disease - COVID-19 -0.529565217 -0.700592885 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Coronavirus disease - COVID-19 -0.565217391 -0.484189723 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Coronavirus disease - COVID-19 -0.531304348 -0.654150198 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Coronavirus disease - COVID-19 0.72173913 0.805335968 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Coronavirus disease - COVID-19 -0.484347826 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Coronavirus disease - COVID-19 0 -0.420948617 0 kegg kegg NA NA no no no no no no Olfactory transduction Coronavirus disease - COVID-19 -0.484347826 -0.46541502 0 kegg kegg NA NA no no no no no no Oocyte meiosis Coronavirus disease - COVID-19 0.504347826 0.554347826 0 kegg kegg NA NA no no no no no no Oscillospira Coronavirus disease - COVID-19 0 -0.476284585 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Coronavirus disease - COVID-19 -0.570434783 -0.635375494 0 kegg kegg NA NA no no no no no no Other glycan degradation Coronavirus disease - COVID-19 0 -0.640316206 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Coronavirus disease - COVID-19 0.457391304 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Coronavirus disease - COVID-19 0.692173913 0.85770751 0 kegg kegg NA NA no no no no no no Pancreatic secretion Coronavirus disease - COVID-19 0.459130435 0.600790514 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Coronavirus disease - COVID-19 -0.625217391 -0.735177866 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Coronavirus disease - COVID-19 0.692173913 0.781620553 0.484169884 kegg kegg NA NA no no no no no no Parkinson disease Coronavirus disease - COVID-19 0.82173913 0.860671937 0.58996139 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Coronavirus disease - COVID-19 -0.586086957 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Coronavirus disease - COVID-19 0.823478261 0.855731225 0.575546976 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Coronavirus disease - COVID-19 0 0.491106719 0.416988417 kegg kegg NA NA no no no no no no Pentose phosphate pathway Coronavirus disease - COVID-19 -0.655652174 -0.471343874 0 kegg kegg NA NA no no no no no no Peroxisome Coronavirus disease - COVID-19 -0.58 -0.601778656 0 kegg kegg NA NA no no no no no no Pertussis Coronavirus disease - COVID-19 -0.737391304 -0.579051383 -0.455598456 kegg kegg NA NA no no dn no no no Phagosome Coronavirus disease - COVID-19 -0.630434783 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Coronavirus disease - COVID-19 0.517391304 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Coronavirus disease - COVID-19 0 -0.711462451 -0.490604891 kegg kegg NA NA no up up no no no Phototransduction Coronavirus disease - COVID-19 0 0.59486166 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Coronavirus disease - COVID-19 0 0 0.621621622 yes kegg kegg NA NA no up up no no no Platinum drug resistance Coronavirus disease - COVID-19 0 -0.427865613 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Coronavirus disease - COVID-19 0 -0.469367589 0 kegg kegg NA NA no no no no no no Prion disease Coronavirus disease - COVID-19 0.633913043 0.887351779 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Coronavirus disease - COVID-19 0 -0.635375494 -0.502702703 kegg kegg NA NA no no no no no no Propanoate metabolism Coronavirus disease - COVID-19 0 0.663043478 0.647361647 kegg kegg NA NA no no no no no no Proteasome Coronavirus disease - COVID-19 0 0.541501976 0.434491634 kegg kegg NA NA no no no no no no Protein digestion and absorption Coronavirus disease - COVID-19 -0.528695652 -0.726284585 -0.523809524 yes kegg kegg NA NA no up up no no no Protein export Coronavirus disease - COVID-19 0.677391304 0.757905138 0.526898327 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Coronavirus disease - COVID-19 0 0.571146245 0.64015444 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Coronavirus disease - COVID-19 0 0.48715415 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Coronavirus disease - COVID-19 -0.474782609 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Coronavirus disease - COVID-19 0 0.725296443 0.590990991 kegg kegg NA NA no no no no no no Ras signaling pathway Coronavirus disease - COVID-19 0 0.435770751 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Coronavirus disease - COVID-19 0 0.457509881 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Coronavirus disease - COVID-19 0.525217391 0 0 kegg kegg NA NA no no no no no no Renin secretion Coronavirus disease - COVID-19 0 0.67687747 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Coronavirus disease - COVID-19 -0.479130435 -0.481225296 -0.449420849 kegg kegg NA NA no no no no no no Retinol metabolism Coronavirus disease - COVID-19 -0.47826087 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Coronavirus disease - COVID-19 0.415652174 0.864624506 0 kegg kegg NA NA no no up no no no Ribosome Coronavirus disease - COVID-19 0.999130435 0.999011858 0.9997426 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Coronavirus disease - COVID-19 0.424347826 0 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Coronavirus disease - COVID-19 0 -0.646245059 0 kegg kegg NA NA no no no no no no RNA degradation Coronavirus disease - COVID-19 0.740869565 0.645256917 0 kegg kegg NA NA no no no no no no RNA polymerase Coronavirus disease - COVID-19 0.528695652 0.504940711 0.465122265 kegg kegg NA NA no no no no no no RNA transport Coronavirus disease - COVID-19 0 0.81916996 0.607722008 kegg kegg NA NA no no no no no no Ruminococcus Coronavirus disease - COVID-19 0.437391304 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Salmonella infection Coronavirus disease - COVID-19 -0.604347826 0 0 kegg kegg NA NA no no no no no no Shigellosis Coronavirus disease - COVID-19 0.683478261 0.783596838 0.52972973 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Coronavirus disease - COVID-19 0.526956522 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Coronavirus disease - COVID-19 0 -0.764822134 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Coronavirus disease - COVID-19 0.54 0 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Coronavirus disease - COVID-19 -0.737391304 0 0 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Coronavirus disease - COVID-19 -0.634782609 -0.757905138 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Coronavirus disease - COVID-19 0 -0.460474308 0 kegg kegg NA NA no up up no no no Taurine and hypotaurine metabolism Coronavirus disease - COVID-19 0 -0.485177866 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Coronavirus disease - COVID-19 0.66173913 0.727272727 0 kegg kegg NA NA no no no no no no Thermogenesis Coronavirus disease - COVID-19 0.754782609 0.890316206 0.542857143 kegg kegg NA NA no no no no no no Thiamine metabolism Coronavirus disease - COVID-19 0 0.590909091 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Coronavirus disease - COVID-19 0 0.477272727 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Coronavirus disease - COVID-19 0.470434783 0.463438735 0 kegg kegg NA NA no no no no no no Tight junction Coronavirus disease - COVID-19 0 0.453557312 0 kegg kegg NA NA no no no no no no TNF signaling pathway Coronavirus disease - COVID-19 0 -0.556324111 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Coronavirus disease - COVID-19 0 -0.580039526 0 yes kegg kegg NA NA no no no no no no Toxoplasmosis Coronavirus disease - COVID-19 -0.473913043 -0.450592885 0 kegg kegg NA NA no no no no no no Tuberculosis Coronavirus disease - COVID-19 -0.726086957 -0.462450593 0 kegg kegg NA NA no no dn no no no Type II diabetes mellitus Coronavirus disease - COVID-19 0 -0.591897233 -0.505019305 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Coronavirus disease - COVID-19 0.786086957 0.749011858 0.566537967 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Coronavirus disease - COVID-19 0.68173913 0.681818182 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Coronavirus disease - COVID-19 0.423478261 0.643280632 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Coronavirus disease - COVID-19 0 -0.41798419 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Coronavirus disease - COVID-19 0 0.467391304 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Coronavirus disease - COVID-19 0.466086957 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Coronavirus disease - COVID-19 0.604347826 0.554347826 0 kegg kegg NA NA no no no no no no Yersinia infection Coronavirus disease - COVID-19 -0.55826087 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Cortisol synthesis and secretion 0 0 -0.51042471 kegg kegg NA NA no no no no no up Adipocytokine signaling pathway Cortisol synthesis and secretion 0 0 0.441184041 kegg kegg NA NA no no no no no up Adrenergic signaling in cardiomyocytes Cortisol synthesis and secretion 0.592173913 0.636363636 0.716344916 kegg kegg NA NA no no up no no up Aldosterone synthesis and secretion Cortisol synthesis and secretion 0.810434783 0.79743083 0.85971686 kegg kegg NA NA no up up no no up alpha-Linolenic acid metabolism Cortisol synthesis and secretion -0.503478261 0 -0.682625483 kegg kegg NA NA no no no no no up Amino sugar and nucleotide sugar metabolism Cortisol synthesis and secretion 0 0 -0.498584299 kegg kegg NA NA no no no no no up AMPK signaling pathway Cortisol synthesis and secretion 0.551304348 0.681818182 0.405405405 kegg kegg NA NA no no no no no up Antigen processing and presentation Cortisol synthesis and secretion -0.546956522 -0.584980237 0 kegg kegg NA NA no no no no no up Arginine and proline metabolism Cortisol synthesis and secretion -0.577391304 0 0 kegg kegg NA NA no up no no no up Arginine biosynthesis Cortisol synthesis and secretion -0.432173913 0 0 kegg kegg NA NA no no no no no up Ascorbate and aldarate metabolism Cortisol synthesis and secretion 0 0 -0.5997426 kegg kegg NA NA no no no no no up beta-Alanine metabolism Cortisol synthesis and secretion 0 -0.421936759 -0.612612613 kegg kegg NA NA no no no no no up Biosynthesis of amino acids Cortisol synthesis and secretion -0.480869565 -0.665019763 -0.432689833 kegg kegg NA NA no no no no no up Biosynthesis of cofactors Cortisol synthesis and secretion 0 0.472332016 0 kegg kegg NA NA no no no no no up Biosynthesis of unsaturated fatty acids Cortisol synthesis and secretion 0 0 -0.413127413 kegg kegg NA NA no no no no no up Butanoate metabolism Cortisol synthesis and secretion 0 0 -0.43963964 kegg kegg NA NA no no no no no up Calcium signaling pathway Cortisol synthesis and secretion 0.540869565 0.626482213 0.796911197 kegg kegg NA NA no up up no no up cAMP signaling pathway Cortisol synthesis and secretion 0.425217391 0 0.730759331 yes kegg kegg NA NA no up up no no up Carbon metabolism Cortisol synthesis and secretion -0.439130435 -0.773715415 -0.619305019 kegg kegg NA NA no no no no no up Cell adhesion molecules Cortisol synthesis and secretion 0 -0.735177866 0 kegg kegg NA NA no no no no no up Cell cycle Cortisol synthesis and secretion 0 0.41798419 0 kegg kegg NA NA no no no no no up Cellular senescence Cortisol synthesis and secretion 0 -0.506916996 0 kegg kegg NA NA no no no no no up cGMP-PKG signaling pathway Cortisol synthesis and secretion 0 -0.545454545 0 kegg kegg NA NA no no no no no up Circadian entrainment Cortisol synthesis and secretion 0.511304348 0 0.681595882 kegg kegg NA NA no up up no no up Circadian rhythm Cortisol synthesis and secretion 0 0.583992095 0 kegg kegg NA NA no no no no no up Citrate cycle (TCA cycle) Cortisol synthesis and secretion 0 0 -0.584041184 kegg kegg NA NA no no no no no up Clostridium Cortisol synthesis and secretion 0 -0.498195877 0 Genus kegg 0.925 NA no no no no no up Complement and coagulation cascades Cortisol synthesis and secretion 0 -0.549407115 0 kegg kegg NA NA no no no no no up Cytokine-cytokine receptor interaction Cortisol synthesis and secretion 0 -0.420948617 0 kegg kegg NA NA no no no no no up Dopaminergic synapse Cortisol synthesis and secretion 0.584347826 0.570158103 0.724066924 kegg kegg NA NA no up no no no up Drug metabolism - other enzymes Cortisol synthesis and secretion -0.520869565 0 -0.625740026 kegg kegg NA NA no no no no no up Endocrine resistance Cortisol synthesis and secretion 0.844347826 0.887351779 0.795881596 kegg kegg NA NA no no no no no up Endocytosis Cortisol synthesis and secretion 0 -0.719367589 0 kegg kegg NA NA no no no no no up Ether lipid metabolism Cortisol synthesis and secretion 0.407826087 0.429841897 0 kegg kegg NA NA no no no no no up Fatty acid biosynthesis Cortisol synthesis and secretion -0.499130435 0 0 kegg kegg NA NA no no no no no up Fatty acid degradation Cortisol synthesis and secretion -0.66 0 -0.773230373 kegg kegg NA NA no no no no no up Fatty acid elongation Cortisol synthesis and secretion -0.455652174 -0.549407115 -0.487258687 kegg kegg NA NA no no no no no up Fatty acid metabolism Cortisol synthesis and secretion -0.663478261 -0.480237154 -0.708108108 kegg kegg NA NA no no no no no up Fc gamma R-mediated phagocytosis Cortisol synthesis and secretion -0.713913043 -0.730237154 -0.421621622 kegg kegg NA NA no no no no no up Ferroptosis Cortisol synthesis and secretion 0.512173913 0.43083004 0 kegg kegg NA NA no no no no no up Fructose and mannose metabolism Cortisol synthesis and secretion 0 0 -0.53976834 kegg kegg NA NA no no no no no up GABAergic synapse Cortisol synthesis and secretion -0.422608696 0 0 kegg kegg NA NA no up up no no up Galactose metabolism Cortisol synthesis and secretion -0.41826087 0 -0.557014157 kegg kegg NA NA no no no no no up Gap junction Cortisol synthesis and secretion 0.755652174 0.68083004 0.640669241 kegg kegg NA NA no no no no no up Glucagon signaling pathway Cortisol synthesis and secretion 0.634782609 0.68972332 0.641698842 kegg kegg NA NA no no no no no up Glutamatergic synapse Cortisol synthesis and secretion 0.548695652 0.473320158 0.564736165 kegg kegg NA NA no up up no no up Glutathione metabolism Cortisol synthesis and secretion 0 0.463438735 0 kegg kegg NA NA no no no no no up Glycerophospholipid metabolism Cortisol synthesis and secretion 0 0.416996047 0 kegg kegg NA NA no no up no no up "Glycine, serine and threonine metabolism" Cortisol synthesis and secretion 0.413043478 0.545454545 0 kegg kegg NA NA no up no no no up Glycolysis / Gluconeogenesis Cortisol synthesis and secretion 0 0 -0.544144144 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - keratan sulfate Cortisol synthesis and secretion 0.473913043 0 0 kegg kegg NA NA no no no no no up Glycosaminoglycan degradation Cortisol synthesis and secretion 0 -0.577075099 -0.553410553 kegg kegg NA NA no no up no no up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Cortisol synthesis and secretion 0 0.536561265 0 kegg kegg NA NA no no no no no up Glyoxylate and dicarboxylate metabolism Cortisol synthesis and secretion -0.533043478 0 0 kegg kegg NA NA no no no no no up GnRH signaling pathway Cortisol synthesis and secretion 0.800869565 0.912055336 0.825997426 kegg kegg NA NA no no no no no up Hematopoietic cell lineage Cortisol synthesis and secretion 0 -0.471343874 0 kegg kegg NA NA no no no no no up Hippo signaling pathway - multiple species Cortisol synthesis and secretion -0.471304348 0 0 kegg kegg NA NA no no no no no up Histidine metabolism Cortisol synthesis and secretion -0.451304348 0 -0.666409266 kegg kegg NA NA no no no no no up IL-17 signaling pathway Cortisol synthesis and secretion -0.429565217 -0.5256917 0 kegg kegg NA NA no no no no no up Inflammatory mediator regulation of TRP channels Cortisol synthesis and secretion 0.656521739 0.54743083 0.761389961 kegg kegg NA NA no no no no no up Insulin secretion Cortisol synthesis and secretion 0.953913043 0.953557312 0.975546976 yes kegg kegg NA NA no up up no no up Leukocyte transendothelial migration Cortisol synthesis and secretion 0 -0.45256917 0 kegg kegg NA NA no no no no no up Long-term depression Cortisol synthesis and secretion 0.795652174 0.651185771 0.873873874 kegg kegg NA NA no no no no no up Longevity regulating pathway Cortisol synthesis and secretion 0.579130435 0.48715415 0 kegg kegg NA NA no no no no no up Longevity regulating pathway - multiple species Cortisol synthesis and secretion -0.423478261 -0.725296443 -0.411583012 kegg kegg NA NA no no no no no up Lysine degradation Cortisol synthesis and secretion 0 0.489130435 0 kegg kegg NA NA no no no no no up Lysosome Cortisol synthesis and secretion -0.416521739 -0.704545455 -0.447104247 kegg kegg NA NA no no no no no up Melanogenesis Cortisol synthesis and secretion 0.72 0.589920949 0.828314028 kegg kegg NA NA no no no no no up Metabolism of xenobiotics by cytochrome P450 Cortisol synthesis and secretion 0 0 -0.416473616 kegg kegg NA NA no no no no no up Mitophagy - animal Cortisol synthesis and secretion 0.673913043 0.600790514 0 kegg kegg NA NA no no no no no up mRNA surveillance pathway Cortisol synthesis and secretion 0 0.517786561 0 kegg kegg NA NA no no no no no up Natural killer cell mediated cytotoxicity Cortisol synthesis and secretion 0 -0.617588933 0 kegg kegg NA NA no no no no no up Necroptosis Cortisol synthesis and secretion 0.670434783 0.540513834 0 kegg kegg NA NA no no no no no up Neuroactive ligand-receptor interaction Cortisol synthesis and secretion -0.629565217 -0.798418972 -0.419305019 kegg kegg NA NA up up up no no up Neutrophil extracellular trap formation Cortisol synthesis and secretion -0.52173913 -0.637351779 0 kegg kegg NA NA no no no no no up Nicotinate and nicotinamide metabolism Cortisol synthesis and secretion -0.605217391 0 0 kegg kegg NA NA no no no no no up NOD-like receptor signaling pathway Cortisol synthesis and secretion -0.702608696 0 0 kegg kegg NA NA no no no no no up Non-homologous end-joining Cortisol synthesis and secretion 0 -0.423913043 -0.420592021 kegg kegg NA NA no no no no no up Notch signaling pathway Cortisol synthesis and secretion 0 0.416996047 0 kegg kegg NA NA no no no no no up Odoribacter Cortisol synthesis and secretion 0 -0.653791009 0 butyrate-producing Genus kegg 0.798 NA no no no no no up Olfactory transduction Cortisol synthesis and secretion -0.542608696 -0.563241107 -0.542599743 kegg kegg NA NA no no no no no up Osteoclast differentiation Cortisol synthesis and secretion -0.623478261 -0.554347826 0 kegg kegg NA NA no no no no no up Other types of O-glycan biosynthesis Cortisol synthesis and secretion 0 0.623517787 0 kegg kegg NA NA no no no no no up Ovarian steroidogenesis Cortisol synthesis and secretion 0.799130435 0.81027668 0.758043758 kegg kegg NA NA no up up no no up p53 signaling pathway Cortisol synthesis and secretion 0 0.427865613 0 kegg kegg NA NA no no no no no up Pantothenate and CoA biosynthesis Cortisol synthesis and secretion -0.526956522 -0.448616601 -0.593307593 kegg kegg NA NA no no dn no no up Pentose phosphate pathway Cortisol synthesis and secretion 0 -0.681818182 -0.424453024 kegg kegg NA NA no no no no no up Peroxisome Cortisol synthesis and secretion -0.730434783 -0.517786561 0 kegg kegg NA NA no no no no no up Phagosome Cortisol synthesis and secretion 0 -0.740118577 0 kegg kegg NA NA no no no no no up Phospholipase D signaling pathway Cortisol synthesis and secretion 0 0 0.514285714 kegg kegg NA NA no up up no no up Porphyrin and chlorophyll metabolism Cortisol synthesis and secretion 0.423478261 0.468379447 0 kegg kegg NA NA no no no no no up PPAR signaling pathway Cortisol synthesis and secretion -0.412173913 -0.457509881 0 kegg kegg NA NA no no no no no up Prevotella Cortisol synthesis and secretion 0 0 0.520652881 acetate-producing Genus kegg 0.287 NA no no no no no up Primary bile acid biosynthesis Cortisol synthesis and secretion -0.413913043 -0.455533597 -0.434749035 kegg kegg NA NA no no no no no up Proteasome Cortisol synthesis and secretion 0 0 -0.571428571 kegg kegg NA NA no no no no no up Purine metabolism Cortisol synthesis and secretion 0.444347826 0.554347826 0 kegg kegg NA NA no no no no no up Pyrimidine metabolism Cortisol synthesis and secretion -0.488695652 0 0 kegg kegg NA NA no no no no no up Regulation of lipolysis in adipocytes Cortisol synthesis and secretion 0.793043478 0.835968379 0.814157014 kegg kegg NA NA no no no no no up Relaxin signaling pathway Cortisol synthesis and secretion 0.53826087 0 0.719176319 kegg kegg NA NA no no no no no up Renin secretion Cortisol synthesis and secretion 0.560869565 0.434782609 0.70990991 kegg kegg NA NA no no no no no up Renin-angiotensin system Cortisol synthesis and secretion -0.583478261 -0.675889328 -0.45971686 kegg kegg NA NA no no no no no up Retinol metabolism Cortisol synthesis and secretion -0.439130435 0 -0.512483912 kegg kegg NA NA no no no no no up Ribosome Cortisol synthesis and secretion 0.436521739 0 0 kegg kegg NA NA no no no no no up RNA polymerase Cortisol synthesis and secretion 0 0.43083004 0 kegg kegg NA NA no no no no no up Serotonergic synapse Cortisol synthesis and secretion 0.453913043 0.455533597 0.476447876 kegg kegg NA NA no no no no no up Signaling pathways regulating pluripotency of stem cells Cortisol synthesis and secretion 0 0.445652174 0 kegg kegg NA NA no no no no no up Sphingolipid metabolism Cortisol synthesis and secretion 0 0 -0.505276705 kegg kegg NA NA no no no no no up Sphingolipid signaling pathway Cortisol synthesis and secretion 0 -0.523715415 0 kegg kegg NA NA no no no no no up Starch and sucrose metabolism Cortisol synthesis and secretion -0.544347826 0 -0.621106821 kegg kegg NA NA no no no no no up Steroid hormone biosynthesis Cortisol synthesis and secretion 0 0 -0.568597169 kegg kegg NA NA no no no no no up Synaptic vesicle cycle Cortisol synthesis and secretion -0.417391304 -0.626482213 -0.535392535 kegg kegg NA NA no up up no no up Taurine and hypotaurine metabolism Cortisol synthesis and secretion 0 0.482213439 0 kegg kegg NA NA no no no no no up Th17 cell differentiation Cortisol synthesis and secretion 0 -0.425889328 0 kegg kegg NA NA no no no no no up Thermogenesis Cortisol synthesis and secretion 0.426956522 0 0 kegg kegg NA NA no no no no no up Thyroid hormone synthesis Cortisol synthesis and secretion 0.788695652 0.888339921 0.683397683 kegg kegg NA NA no no no no no up Tryptophan metabolism Cortisol synthesis and secretion -0.46173913 0 -0.640926641 kegg kegg NA NA no up no no no up Ubiquitin mediated proteolysis Cortisol synthesis and secretion 0.708695652 0.638339921 0 kegg kegg NA NA no no no no no up "Valine, leucine and isoleucine degradation" Cortisol synthesis and secretion 0 0 -0.484942085 kegg kegg NA NA no no no no no up Vascular smooth muscle contraction Cortisol synthesis and secretion 0.552173913 0 0.56036036 kegg kegg NA NA no no no no no up 13-HODE+blood CR+clinic 0 0.628571429 0 serum_ARA clinic 0.32 0.978 no no no no no no 14:0/18:2-PC+blood CR+clinic 0 -0.582142857 -0.485384615 serum_phospholipids clinic 0.102 0.978 no up no no no no 14:0/20:4-PC+blood CR+clinic 0 0 -0.499230769 serum_phospholipids clinic 0.486 0.978 no no no no no no 16:0/18:0-PS+blood CR+clinic 0 -0.596428571 0 serum_phospholipids clinic 0.377 0.978 no no no no no no 16:0/18:2-PI+blood CR+clinic 0 0 -0.628461538 serum_phospholipids clinic 0.269 0.978 no no no no no no 16:0/20:4-PC+blood CR+clinic 0.558307534 0 0 serum_phospholipids clinic 0.0262 0.978 no up no no no no 16:0/20:4-PI+blood CR+clinic 0 -0.571428571 -0.473076923 serum_phospholipids clinic 0.558 0.978 no no no no no no 18:0/18:0-PS+blood CR+clinic 0 -0.657142857 0 serum_phospholipids clinic 0.00617 0.978 no up no no no no 18:0/18:2-PI+blood CR+clinic 0 0 -0.486153846 serum_phospholipids clinic 0.179 0.978 no no no no no no 18:0/20:2-PC+blood CR+clinic 0 -0.535714286 0 serum_phospholipids clinic 0.733 0.978 no no no no no no 18:0/20:4-PC+blood CR+clinic 0.490196078 0 0 serum_phospholipids clinic 0.454 0.978 no no no no no no 18:0/20:4-PI+blood CR+clinic 0.595459236 -0.682142857 0 serum_phospholipids clinic 0.167 0.978 no no no no no no 18:0+blood CR+clinic 0 0 -0.427692308 serum_fattyacid clinic 0.344 0.978 no no no no no no 18:1-LPC+blood CR+clinic 0.574819401 0 0 serum_phospholipids clinic 0.179 0.978 no no no no no no 18:1/18:2-PI+blood CR+clinic 0 0 -0.416153846 serum_phospholipids clinic 0.0164 0.978 dn no up no no no 18:2-LPA+blood CR+clinic 0.475748194 0 0 serum_phospholipids clinic 0.00684 0.978 dn no up no no no 2-hydroxyhippuric acid+urine CR+clinic 0 0 0.452307692 urine_cometabolism clinic 0.215 0.978 no no no no no no 20:1+blood CR+clinic 0 0.596428571 0 yes serum_fattyacid clinic 2.56E-05 0.978 dn dn dn no no no 20:3/16:0-PC+blood CR+clinic 0.572755418 0 0 serum_phospholipids clinic 0.00405 0.978 no up up no no no 4-hydroxy-3-methoxymandelic acid+urine CR+clinic 0 0 -0.403846154 urine_cometabolism clinic 0.973 0.978 no no no no no no 5-Hydroxyindole-3-acetic Acid+urine CR+clinic 0 0.632352941 0.416153846 urine_cometabolism clinic 0.0405 0.978 no dn dn no no no 9-HODE+blood CR+clinic 0 0.653571429 0 serum_ARA clinic 0.297 0.978 no no no no no no AA+blood CR+clinic 0 0.560714286 0 serum_ARA clinic 0.212 0.978 no no no no no no Adipocytokine signaling pathway CR+clinic 0 0 -0.508683473 kegg clinic NA 0.978 no no no no no no Alcoholism CR+clinic -0.450028233 0 0 kegg clinic NA 0.978 no no no no no no Anaerostipes CR+clinic -0.530296771 0 0 butyrate-producing Genus clinic 0.568 0.978 no no no no no no Asthma CR+clinic 0.437605872 0 0 kegg clinic NA 0.978 no no no no no no CA+stool CR+clinic -0.541176471 -0.645454545 0 stool_bileacids clinic 0.827 0.978 no no no no no no Calcium signaling pathway CR+clinic 0 0 -0.406162465 kegg clinic NA 0.978 no up up no no no cAMP signaling pathway CR+clinic 0 0 -0.445098039 yes kegg clinic NA 0.978 no up up no no no Carbon metabolism CR+clinic 0 -0.471428571 0 kegg clinic NA 0.978 no no no no no no CDCA+blood CR+clinic -0.562435501 0 0 serum_bileacids clinic 0.506 0.978 no no no no no no CDCA+stool CR+clinic -0.517647059 0 0 stool_bileacids clinic 0.663 0.978 no no no no no no Chemical carcinogenesis - receptor activation CR+clinic 0 0 -0.416246499 kegg clinic NA 0.978 no no no no no no Cholinergic synapse CR+clinic 0 -0.555844156 0 kegg clinic NA 0.978 no no no no no no Chronic myeloid leukemia CR+clinic 0 0 -0.416526611 kegg clinic NA 0.978 no no no no no no Cocaine addiction CR+clinic 0 0 -0.608403361 kegg clinic NA 0.978 no no no no no no Cortisol synthesis and secretion CR+clinic 0 0 -0.578991597 kegg clinic NA 0.978 no no up no no no Creatinine+blood CR+clinic 0.86377709 0.55 0.788461538 serum_choline clinic 0.437 0.978 no no no no no no Cushing syndrome CR+clinic 0 0 -0.531932773 kegg clinic NA 0.978 no no up no no no Cytokine-cytokine receptor interaction CR+clinic 0 -0.571428571 0 kegg clinic NA 0.978 no no no no no no Cytosolic DNA-sensing pathway CR+clinic -0.425183512 0.485714286 0 kegg clinic NA 0.978 no no no no no no d18:0-24:1-SM+blood CR+clinic 0 -0.646428571 0 serum_phospholipids clinic 0.0609 0.978 no dn dn no no no d18:1-14:0-SM+blood CR+clinic 0 -0.567857143 0 serum_phospholipids clinic 0.94 0.978 no no no no no no d18:1-22:1-SM+blood CR+clinic 0 0 -0.407692308 serum_phospholipids clinic 0.222 0.978 no no no no no no Dorea CR+clinic 0 -0.469923769 0 Genus clinic 0.00362 0.978 up no dn no no no Endocrine resistance CR+clinic 0 0 -0.438935574 kegg clinic NA 0.978 no no no no no no Eotaxin CR+clinic 0 0.536842105 0 serum_cytokines clinic 0.393 0.978 no no no no no no Ethanolamine+blood CR+clinic 0.572755418 0 0 serum_aminoacids clinic 0.122 0.978 up no no no no no Fc gamma R-mediated phagocytosis CR+clinic 0 0 0.418487395 kegg clinic NA 0.978 no no no no no no GCA+stool CR+clinic -0.526470588 0 0 stool_bileacids clinic 0.0809 0.978 no no no no no no "Growth hormone synthesis, secretion and action" CR+clinic 0 0 -0.522408964 kegg clinic NA 0.978 no no no no no no HDCA+stool CR+clinic 0.758823529 0 0 stool_bileacids clinic 0.176 0.978 no no no no no no Hematopoietic cell lineage CR+clinic 0.53811406 0 0 kegg clinic NA 0.978 no no no no no no Hepatitis C CR+clinic 0 0 -0.467787115 kegg clinic NA 0.978 no no no no no no IL-1ra CR+clinic 0 -0.578947368 0 yes serum_cytokines clinic 0.0288 0.978 no up no no no no Indole-3-Acetic acid+urine CR+clinic 0 0 0.530769231 urine_cometabolism clinic 0.657 0.978 no no no no no no Inflammatory bowel disease CR+clinic 0.58554489 0 0 kegg clinic NA 0.978 no no no no no no Insulin secretion CR+clinic 0 0 -0.547619048 yes kegg clinic NA 0.978 no up up no no no iso-DCA+blood CR+clinic 0 0.657142857 0 serum_bileacids clinic 0.38 0.978 no no no no no no L-Alanine+blood CR+clinic 0 0 -0.502307692 yes serum_aminoacids clinic 0.00138 0.978 up up no no no no L-Arginine+blood CR+clinic 0.576883385 0 0 serum_aminoacids clinic 0.316 0.978 no no no no no no L-Asparagine+blood CR+clinic 0.479876161 0 0.420769231 serum_aminoacids clinic 0.784 0.978 no no no no no no L-Citrulline+blood CR+clinic 0.609907121 0.553571429 0 serum_aminoacids clinic 0.534 0.978 no no no no no no L-Glutamic acid+blood CR+clinic 0.572755418 0 0 yes serum_aminoacids clinic 6.20E-05 0.978 up up no no no no L-Histidine+blood CR+clinic 0.473684211 0 0 serum_aminoacids clinic 0.109 0.978 no no no no no no L-Isoleucine+blood CR+clinic 0.562435501 0 0 yes serum_aminoacids clinic 5.47E-06 0.978 up up no no no no L-Lysine+blood CR+clinic 0.587203302 0 0 yes serum_aminoacids clinic 0.0107 0.978 no up no no no no L-Methionine+blood CR+clinic 0.583075335 0 0.42 serum_aminoacids clinic 0.626 0.978 no no no no no no L-Ornithine+blood CR+clinic 0 0.7 0 serum_aminoacids clinic 0.175 0.978 no no no no no no L-Tryptophan+blood CR+clinic 0.667698658 0 0 serum_aminoacids clinic 0.164 0.978 no no no no no no L-Tyrosine+urine CR+clinic 0 -0.575980392 0 urine_cometabolism clinic 0.45 0.978 no no no no no no Leptin CR+clinic -0.501976285 -0.460191982 -0.622307105 DM-assocaited hormones clinic 0.706 0.978 no no no no no no Leukocyte transendothelial migration CR+clinic -0.435347261 0 0 kegg clinic NA 0.978 no no no no no no Long-term depression CR+clinic 0 0 -0.527731092 kegg clinic NA 0.978 no no no no no no Longevity regulating pathway - multiple species CR+clinic 0 -0.506493506 0.454061625 kegg clinic NA 0.978 no no no no no no MCP-1(MCAF) CR+clinic 0.675824176 0 0 yes serum_cytokines clinic 0.0633 0.978 dn no no no no no Morphine addiction CR+clinic 0 0 -0.426890756 kegg clinic NA 0.978 no up up no no no MUFA%+blood CR+clinic 0.481940144 0 0.6 serum_fattyacid clinic 0.00142 0.978 up no dn no no no n6/n3+blood CR+clinic 0.539731682 0 0 serum_fattyacid clinic 0.226 0.978 no no no no no no Neuroactive ligand-receptor interaction CR+clinic 0 0 0.451540616 kegg clinic NA 0.978 up up up no no no nutriCA+blood CR+clinic -0.529387576 0 0 serum_bileacids clinic 0.726 0.978 no no no no no no nutriCA+stool CR+clinic 0 -0.788156942 0 stool_bileacids clinic 0.481 0.978 no no no no no no P-hydroxyhippuric acid+urine CR+clinic 0 0.56372549 0 urine_cometabolism clinic 0.436 0.978 no no no no no no PDGF-bb CR+clinic 0 0.489473684 0 yes serum_cytokines clinic 0.111 0.978 no no no no no no Relaxin signaling pathway CR+clinic 0 0 -0.559943978 kegg clinic NA 0.978 no no no no no no RIG-I-like receptor signaling pathway CR+clinic 0 0 -0.482913165 kegg clinic NA 0.978 no no no no no no Small cell lung cancer CR+clinic 0 0 -0.48767507 kegg clinic NA 0.978 no no up no no no Toxoplasmosis CR+clinic 0.446640316 0 0 kegg clinic NA 0.978 no no no no no no Tuberculosis CR+clinic 0 0 0.407843137 kegg clinic NA 0.978 no no dn no no no TUDCA+stool CR+clinic 0 0.705458603 0 stool_bileacids clinic 0.241 0.978 no no no no no no Valine+blood CR+clinic 0.587203302 0 0 yes serum_aminoacids clinic 1.22E-06 0.978 up up no no no no Viral protein interaction with cytokine and cytokine receptor CR+clinic -0.437605872 0 0 kegg clinic NA 0.978 no no no no no no 14:0-LPC+blood Creatinine+blood -0.502255639 0 0 serum_phospholipids serum_choline 0.00689 0.437 up up no no no no 14:0/18:2-PC+blood Creatinine+blood -0.511278195 -0.495098039 -0.422905983 serum_phospholipids serum_choline 0.102 0.437 no up no no no no 14:0/20:4-PC+blood Creatinine+blood -0.613533835 0 -0.53982906 serum_phospholipids serum_choline 0.486 0.437 no no no no no no 14:1/18:2-PG+blood Creatinine+blood -0.448120301 0 -0.527521368 serum_phospholipids serum_choline 0.00259 0.437 no up up no no no 16:0/14:0-PC+blood Creatinine+blood 0.506766917 0 0 serum_phospholipids serum_choline 0.0206 0.437 no up up no no no 16:0/16:0-PI+blood Creatinine+blood 0 0 -0.472136752 serum_phospholipids serum_choline 0.358 0.437 no no no no no no 16:0/16:1-PI+blood Creatinine+blood -0.604511278 0 0 serum_phospholipids serum_choline 0.262 0.437 no no no no no no 16:0/18:1-PC+blood Creatinine+blood 0.461654135 0 0 serum_phospholipids serum_choline 6.15E-07 0.437 up up up no no no 16:0/18:2-PI+blood Creatinine+blood 0 0 -0.411965812 serum_phospholipids serum_choline 0.269 0.437 no no no no no no 16:0/20:4-PC+blood Creatinine+blood 0.466165414 0 0 serum_phospholipids serum_choline 0.0262 0.437 no up no no no no 16:0/20:4-PI+blood Creatinine+blood -0.508270677 0 -0.435897436 serum_phospholipids serum_choline 0.558 0.437 no no no no no no 16:0/20:5-PC+blood Creatinine+blood 0 -0.534313725 0 serum_phospholipids serum_choline 0.628 0.437 no no no no no no 16:1/16:0-PC+blood Creatinine+blood 0.530827068 0 0 serum_phospholipids serum_choline 0.0215 0.437 no up up no no no 18:0/16:0-PC+blood Creatinine+blood 0.476691729 0 0 serum_phospholipids serum_choline 9.64E-07 0.437 up up up no no no 18:0/18:0-PE+blood Creatinine+blood -0.467669173 0 0 serum_phospholipids serum_choline 0.00896 0.437 up up no no no no 18:0/18:1-PE+blood Creatinine+blood -0.508270677 0 0 serum_phospholipids serum_choline 0.00716 0.437 up up no no no no 18:0/18:2-PI+blood Creatinine+blood 0 0 -0.407179487 serum_phospholipids serum_choline 0.179 0.437 no no no no no no 18:0/20:3-PI+blood Creatinine+blood 0.572932331 0 0 serum_phospholipids serum_choline 0.377 0.437 no no no no no no 18:0/20:4-PI+blood Creatinine+blood 0.472180451 0 0 serum_phospholipids serum_choline 0.167 0.437 no no no no no no 18:1-LPC+blood Creatinine+blood 0.590977444 0 0 serum_phospholipids serum_choline 0.179 0.437 no no no no no no 18:1/18:0-PS+blood Creatinine+blood 0 -0.522058824 0 serum_phospholipids serum_choline 0.193 0.437 no no no no no no 18:1/22:6-PE+blood Creatinine+blood 0 0 0.506324786 serum_phospholipids serum_choline 0.0047 0.437 no up no no no no 18:2-LPA+blood Creatinine+blood 0 0.654411765 0 serum_phospholipids serum_choline 0.00684 0.437 dn no up no no no 18:2/16:0-PC+blood Creatinine+blood 0.452631579 0 0 serum_phospholipids serum_choline 8.67E-05 0.437 no up up no no no 18:3/16:0-PE+blood Creatinine+blood -0.544360902 0 0 serum_phospholipids serum_choline 0.00149 0.437 up up no no no no 18:3n6+blood Creatinine+blood -0.714285714 0 0 serum_fattyacid serum_choline 0.0463 0.437 up no dn no no no 20:0+blood Creatinine+blood 0 -0.566176471 0 yes serum_fattyacid serum_choline 0.000278 0.437 dn no up no no no 20:1-LPA+blood Creatinine+blood 0 0.487745098 0 serum_phospholipids serum_choline 0.0187 0.437 dn dn no no no no 20:2+blood Creatinine+blood 0 0 0.42017094 serum_fattyacid serum_choline 0.478 0.437 no no no no no no 20:3/16:0-PC+blood Creatinine+blood 0.487218045 0 0 serum_phospholipids serum_choline 0.00405 0.437 no up up no no no 20:3/18:0-PI+blood Creatinine+blood 0.460150376 0 0 serum_phospholipids serum_choline 0.289 0.437 no no no no no no 20:5n3+blood Creatinine+blood 0 -0.556372549 0 serum_fattyacid serum_choline 0.988 0.437 no no no no no no 24:1+blood Creatinine+blood 0.488721805 0 0 serum_fattyacid serum_choline 0.00582 0.437 no dn dn no no no 5-HETE+blood Creatinine+blood 0 0.527365238 0 serum_ARA serum_choline 0.697 0.437 no no no no no no Betaine+blood Creatinine+blood 0.505263158 0 0 serum_choline serum_choline 0.857 0.437 no no no no no no Biosynthesis of cofactors Creatinine+blood -0.463157895 0 0 kegg serum_choline NA 0.437 no no no no no no Blautia Creatinine+blood 0 0.634803922 0 acetate-producing Genus serum_choline 1.36E-05 0.437 up dn dn no no no Butyricimonas Creatinine+blood 0 -0.571426844 0 butyrate-producing Genus serum_choline 0.17 0.437 no no no no no no CDCA+blood Creatinine+blood -0.512781955 0 0 serum_bileacids serum_choline 0.506 0.437 no no no no no no cGMP-PKG signaling pathway Creatinine+blood 0.468421053 0 0 kegg serum_choline NA 0.437 no no no no no no Choline+blood Creatinine+blood 0.717293233 0.62254902 0 serum_choline serum_choline 0.0395 0.437 no up no no no no Cocaine addiction Creatinine+blood 0 0 -0.443846154 kegg serum_choline NA 0.437 no no no no no no Cortisol synthesis and secretion Creatinine+blood 0 0 -0.483076923 kegg serum_choline NA 0.437 no no up no no no Cushing syndrome Creatinine+blood 0 0 -0.49 kegg serum_choline NA 0.437 no no up no no no ErbB signaling pathway Creatinine+blood 0 0 -0.404615385 kegg serum_choline NA 0.437 no no no no no no Fc epsilon RI signaling pathway Creatinine+blood 0.559649123 0 0 kegg serum_choline NA 0.437 no no no no no no Fc gamma R-mediated phagocytosis Creatinine+blood 0 0 0.505384615 kegg serum_choline NA 0.437 no no no no no no GCDCA+stool Creatinine+blood 0 0 -0.466165414 yes stool_bileacids serum_choline 0.0471 0.437 no dn no no no no Glucagon signaling pathway Creatinine+blood 0 0 -0.426923077 kegg serum_choline NA 0.437 no no no no no no "Glycine, serine and threonine metabolism" Creatinine+blood -0.485964912 0 0 kegg serum_choline NA 0.437 no up no no no no Glycolysis / Gluconeogenesis Creatinine+blood -0.457894737 0 0 kegg serum_choline NA 0.437 no no no no no no "Growth hormone synthesis, secretion and action" Creatinine+blood 0 0 -0.452307692 kegg serum_choline NA 0.437 no no no no no no Insulin secretion Creatinine+blood 0 0 -0.417692308 yes kegg serum_choline NA 0.437 no up up no no no Legionellosis Creatinine+blood -0.563157895 0 0 kegg serum_choline NA 0.437 no no no no no no Leishmaniasis Creatinine+blood -0.484210526 0 0 kegg serum_choline NA 0.437 no no no no no no mRNA surveillance pathway Creatinine+blood 0 0 -0.400769231 kegg serum_choline NA 0.437 no no no no no no Neuroactive ligand-receptor interaction Creatinine+blood 0 0 0.446923077 kegg serum_choline NA 0.437 up up up no no no Prolactin signaling pathway Creatinine+blood 0.49122807 0 0 kegg serum_choline NA 0.437 no no no no no no Proteasome Creatinine+blood 0 0 0.455384615 kegg serum_choline NA 0.437 no no no no no no Ras signaling pathway Creatinine+blood 0 -0.538235294 0 yes kegg serum_choline NA 0.437 no up up no no no RNA transport Creatinine+blood -0.531578947 0 0 kegg serum_choline NA 0.437 no no no no no no TCA+stool Creatinine+blood -0.643742012 0 0 stool_bileacids serum_choline 0.458 0.437 no no no no no no Adrenergic signaling in cardiomyocytes Cushing syndrome 0.612173913 0.682806324 0.812870013 kegg kegg NA NA no no up no no up "Alanine, aspartate and glutamate metabolism" Cushing syndrome -0.591304348 0 -0.444272844 kegg kegg NA NA no no no no no up Aldosterone synthesis and secretion Cushing syndrome 0.85826087 0.865612648 0.853281853 kegg kegg NA NA no up up no no up alpha-Linolenic acid metabolism Cushing syndrome -0.54173913 0 -0.573745174 kegg kegg NA NA no no no no no up Amino sugar and nucleotide sugar metabolism Cushing syndrome 0 0 -0.461518662 kegg kegg NA NA no no no no no up AMPK signaling pathway Cushing syndrome 0.506086957 0.735177866 0 kegg kegg NA NA no no no no no up Antifolate resistance Cushing syndrome 0 0.477272727 0 kegg kegg NA NA no no no no no up Antigen processing and presentation Cushing syndrome -0.594782609 -0.56916996 -0.461003861 kegg kegg NA NA no no no no no up Apoptosis Cushing syndrome -0.445217391 -0.515810277 -0.447104247 kegg kegg NA NA no no no no no up Arginine and proline metabolism Cushing syndrome -0.728695652 -0.424901186 0 kegg kegg NA NA no up no no no up Arginine biosynthesis Cushing syndrome -0.617391304 0 -0.447361647 kegg kegg NA NA no no no no no up Basal transcription factors Cushing syndrome 0 0.500988142 0 kegg kegg NA NA no no no no no up Base excision repair Cushing syndrome 0 0.476284585 0 kegg kegg NA NA no no no no no up beta-Alanine metabolism Cushing syndrome 0 0 -0.552123552 kegg kegg NA NA no no no no no up Biosynthesis of amino acids Cushing syndrome -0.563478261 -0.790513834 -0.685714286 kegg kegg NA NA no no no no no up Biosynthesis of cofactors Cushing syndrome 0 0.572134387 0 kegg kegg NA NA no no no no no up Blautia Cushing syndrome -0.469565217 0 0 acetate-producing Genus kegg 1.36E-05 NA up dn dn no no up Calcium signaling pathway Cushing syndrome 0.616521739 0.641304348 0.871814672 kegg kegg NA NA no up up no no up cAMP signaling pathway Cushing syndrome 0.419130435 0 0.636293436 yes kegg kegg NA NA no up up no no up Carbon metabolism Cushing syndrome -0.46 -0.792490119 -0.751093951 kegg kegg NA NA no no no no no up Cardiac muscle contraction Cushing syndrome 0.499130435 0.438735178 0 kegg kegg NA NA no no up no no up Cell adhesion molecules Cushing syndrome 0 -0.809288538 0 kegg kegg NA NA no no no no no up Cell cycle Cushing syndrome 0 0.599802372 0.456113256 kegg kegg NA NA no no no no no up Cellular senescence Cushing syndrome 0 -0.603754941 0 kegg kegg NA NA no no no no no up cGMP-PKG signaling pathway Cushing syndrome 0 -0.68972332 0 kegg kegg NA NA no no no no no up Chemokine signaling pathway Cushing syndrome 0 -0.438735178 0 kegg kegg NA NA no no no no no up Circadian entrainment Cushing syndrome 0.51826087 0 0.470527671 kegg kegg NA NA no up up no no up Circadian rhythm Cushing syndrome 0 0.760869565 0.533848134 kegg kegg NA NA no no no no no up Clostridium Cushing syndrome -0.434892182 -0.492083044 0 Genus kegg 0.925 NA no no no no no up Complement and coagulation cascades Cushing syndrome 0 -0.688735178 -0.437065637 kegg kegg NA NA no no no no no up Cortisol synthesis and secretion Cushing syndrome 0.880869565 0.949604743 0.874903475 kegg kegg NA NA no no up no no up Cytokine-cytokine receptor interaction Cushing syndrome 0 -0.470355731 0 kegg kegg NA NA no no no no no up Dopaminergic synapse Cushing syndrome 0.56173913 0.559288538 0.726640927 kegg kegg NA NA no up no no no up Drug metabolism - cytochrome P450 Cushing syndrome 0 0 -0.472844273 kegg kegg NA NA no no no no no up Drug metabolism - other enzymes Cushing syndrome -0.43826087 0 -0.589189189 kegg kegg NA NA no no no no no up ECM-receptor interaction Cushing syndrome 0 0 0.521235521 kegg kegg NA NA no up up no no up Endocrine resistance Cushing syndrome 0.790434783 0.834980237 0.75006435 kegg kegg NA NA no no no no no up Endocytosis Cushing syndrome 0 -0.800395257 0 kegg kegg NA NA no no no no no up Ether lipid metabolism Cushing syndrome 0.440869565 0.568181818 0 kegg kegg NA NA no no no no no up Fanconi anemia pathway Cushing syndrome 0 0.449604743 0 kegg kegg NA NA no no no no no up Fatty acid biosynthesis Cushing syndrome -0.635652174 -0.434782609 0 kegg kegg NA NA no no no no no up Fatty acid degradation Cushing syndrome -0.688695652 -0.441699605 -0.713513514 kegg kegg NA NA no no no no no up Fatty acid elongation Cushing syndrome 0 -0.508893281 -0.445045045 kegg kegg NA NA no no no no no up Fatty acid metabolism Cushing syndrome -0.719130435 -0.555335968 -0.697039897 kegg kegg NA NA no no no no no up Fc epsilon RI signaling pathway Cushing syndrome 0 -0.472332016 0 kegg kegg NA NA no no no no no up Fc gamma R-mediated phagocytosis Cushing syndrome -0.65826087 -0.83201581 -0.567567568 kegg kegg NA NA no no no no no up Fructose and mannose metabolism Cushing syndrome 0 0 -0.581724582 kegg kegg NA NA no no no no no up GABAergic synapse Cushing syndrome -0.472173913 0 0 kegg kegg NA NA no up up no no up Galactose metabolism Cushing syndrome -0.468695652 0 -0.478249678 kegg kegg NA NA no no no no no up Gap junction Cushing syndrome 0.673043478 0.542490119 0.405662806 kegg kegg NA NA no no no no no up Glucagon signaling pathway Cushing syndrome 0.785217391 0.789525692 0.821879022 kegg kegg NA NA no no no no no up Glutamatergic synapse Cushing syndrome 0.443478261 0 0 kegg kegg NA NA no up up no no up Glutathione metabolism Cushing syndrome 0 0.505928854 0 kegg kegg NA NA no no no no no up Glycerophospholipid metabolism Cushing syndrome 0 0.444664032 0 kegg kegg NA NA no no up no no up "Glycine, serine and threonine metabolism" Cushing syndrome 0 0.581027668 0 kegg kegg NA NA no up no no no up Glycolysis / Gluconeogenesis Cushing syndrome 0 0 -0.54028314 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Cushing syndrome -0.42 0 0 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - keratan sulfate Cushing syndrome 0.546956522 0 0.496267696 kegg kegg NA NA no no no no no up Glycosaminoglycan degradation Cushing syndrome 0 -0.661067194 -0.431917632 kegg kegg NA NA no no up no no up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Cushing syndrome 0 0.605731225 0 kegg kegg NA NA no no no no no up Glyoxylate and dicarboxylate metabolism Cushing syndrome -0.719130435 -0.442687747 -0.503732304 kegg kegg NA NA no no no no no up GnRH signaling pathway Cushing syndrome 0.764347826 0.880434783 0.768597169 kegg kegg NA NA no no no no no up Hedgehog signaling pathway Cushing syndrome 0.512173913 0.470355731 0 kegg kegg NA NA no no no no no up Hippo signaling pathway - multiple species Cushing syndrome -0.546086957 0 0 kegg kegg NA NA no no no no no up Histidine metabolism Cushing syndrome -0.422608696 0 -0.575289575 kegg kegg NA NA no no no no no up IL-17 signaling pathway Cushing syndrome -0.542608696 -0.679841897 -0.482882883 kegg kegg NA NA no no no no no up Inflammatory mediator regulation of TRP channels Cushing syndrome 0.7 0.60770751 0.814414414 kegg kegg NA NA no no no no no up Insulin secretion Cushing syndrome 0.893913043 0.93972332 0.862548263 yes kegg kegg NA NA no up up no no up Leukocyte transendothelial migration Cushing syndrome 0 -0.515810277 0 kegg kegg NA NA no no no no no up Long-term depression Cushing syndrome 0.727826087 0.501976285 0.642213642 kegg kegg NA NA no no no no no up Longevity regulating pathway Cushing syndrome 0.474782609 0.516798419 0 kegg kegg NA NA no no no no no up Longevity regulating pathway - multiple species Cushing syndrome 0 -0.631422925 0 kegg kegg NA NA no no no no no up Lysine degradation Cushing syndrome 0 0.605731225 0 kegg kegg NA NA no no no no no up Lysosome Cushing syndrome -0.517391304 -0.833003953 -0.638867439 kegg kegg NA NA no no no no no up Mannose type O-glycan biosynthesis Cushing syndrome 0.409565217 0.53458498 0 kegg kegg NA NA no no no no no up Melanogenesis Cushing syndrome 0.853043478 0.64229249 0.837580438 kegg kegg NA NA no no no no no up Metabolism of xenobiotics by cytochrome P450 Cushing syndrome 0 0 -0.507593308 kegg kegg NA NA no no no no no up Mitophagy - animal Cushing syndrome 0.572173913 0.600790514 0 kegg kegg NA NA no no no no no up mRNA surveillance pathway Cushing syndrome 0.429565217 0.679841897 0.581981982 kegg kegg NA NA no no no no no up N-Glycan biosynthesis Cushing syndrome 0 0.416007905 0.409009009 kegg kegg NA NA no no no no no up Natural killer cell mediated cytotoxicity Cushing syndrome 0 -0.707509881 0 kegg kegg NA NA no no no no no up Necroptosis Cushing syndrome 0.506956522 0.414031621 0 kegg kegg NA NA no no no no no up Neuroactive ligand-receptor interaction Cushing syndrome -0.563478261 -0.864624506 -0.558043758 kegg kegg NA NA up up up no no up Neutrophil extracellular trap formation Cushing syndrome -0.593043478 -0.792490119 -0.578378378 kegg kegg NA NA no no no no no up NF-kappa B signaling pathway Cushing syndrome -0.414782609 0 0 kegg kegg NA NA no no no no no up Nicotinate and nicotinamide metabolism Cushing syndrome -0.706956522 -0.469367589 -0.470785071 kegg kegg NA NA no no no no no up Nitrogen metabolism Cushing syndrome -0.480869565 0 0 kegg kegg NA NA no no no no no up NOD-like receptor signaling pathway Cushing syndrome -0.73826087 -0.463438735 0 kegg kegg NA NA no no no no no up Non-alcoholic fatty liver disease Cushing syndrome 0.505217391 0.4743083 0 kegg kegg NA NA no no no no no up Odoribacter Cushing syndrome -0.495657053 -0.576524799 0 butyrate-producing Genus kegg 0.798 NA no no no no no up Olfactory transduction Cushing syndrome -0.475652174 -0.711462451 -0.688545689 kegg kegg NA NA no no no no no up Osteoclast differentiation Cushing syndrome -0.682608696 -0.662055336 0 kegg kegg NA NA no no no no no up Other glycan degradation Cushing syndrome -0.434782609 0 0 kegg kegg NA NA no no no no no up Other types of O-glycan biosynthesis Cushing syndrome 0 0.721343874 0 kegg kegg NA NA no no no no no up Ovarian steroidogenesis Cushing syndrome 0.737391304 0.66798419 0.474646075 kegg kegg NA NA no up up no no up Oxidative phosphorylation Cushing syndrome 0.426086957 0.421936759 0 kegg kegg NA NA no no no no no up p53 signaling pathway Cushing syndrome 0 0.518774704 0 kegg kegg NA NA no no no no no up Pantothenate and CoA biosynthesis Cushing syndrome -0.564347826 -0.576086957 -0.663577864 kegg kegg NA NA no no dn no no up "Parathyroid hormone synthesis, secretion and action" Cushing syndrome 0.593043478 0.627470356 0.593822394 kegg kegg NA NA no no no no no up Pentose phosphate pathway Cushing syndrome -0.44 -0.827075099 -0.662805663 kegg kegg NA NA no no no no no up Peroxisome Cushing syndrome -0.766956522 -0.579051383 -0.488803089 kegg kegg NA NA no no no no no up Phagosome Cushing syndrome 0 -0.848814229 -0.475675676 kegg kegg NA NA no no no no no up Phosphatidylinositol signaling system Cushing syndrome 0.422608696 0 0 kegg kegg NA NA no no no no no up Phospholipase D signaling pathway Cushing syndrome 0 0 0.433719434 kegg kegg NA NA no up up no no up Porphyrin and chlorophyll metabolism Cushing syndrome 0 0.518774704 0 kegg kegg NA NA no no no no no up PPAR signaling pathway Cushing syndrome -0.60173913 -0.543478261 0 kegg kegg NA NA no no no no no up Prevotella Cushing syndrome 0 0 0.553025813 acetate-producing Genus kegg 0.287 NA no no no no no up Primary bile acid biosynthesis Cushing syndrome 0 0 -0.447876448 kegg kegg NA NA no no no no no up Proteasome Cushing syndrome -0.460869565 0 -0.525096525 kegg kegg NA NA no no no no no up Protein processing in endoplasmic reticulum Cushing syndrome 0.491304348 0.528656126 0 kegg kegg NA NA no no no no no up Purine metabolism Cushing syndrome 0 0.625494071 0 kegg kegg NA NA no no no no no up Pyrimidine metabolism Cushing syndrome -0.433043478 0 0 kegg kegg NA NA no no no no no up Regulation of lipolysis in adipocytes Cushing syndrome 0.708695652 0.708498024 0.644530245 kegg kegg NA NA no no no no no up Relaxin signaling pathway Cushing syndrome 0 0 0.543114543 kegg kegg NA NA no no no no no up Renin secretion Cushing syndrome 0.626956522 0.467391304 0.55984556 kegg kegg NA NA no no no no no up Renin-angiotensin system Cushing syndrome -0.508695652 -0.778656126 -0.462805663 kegg kegg NA NA no no no no no up Ribosome Cushing syndrome 0.506956522 0 0 kegg kegg NA NA no no no no no up Ribosome biogenesis in eukaryotes Cushing syndrome 0 0.526679842 0 kegg kegg NA NA no no no no no up RNA degradation Cushing syndrome 0 0.537549407 0 kegg kegg NA NA no no no no no up RNA polymerase Cushing syndrome 0 0.606719368 0 kegg kegg NA NA no no no no no up Selenocompound metabolism Cushing syndrome 0 0.440711462 0 kegg kegg NA NA no no no no no up Signaling pathways regulating pluripotency of stem cells Cushing syndrome 0.462608696 0.548418972 0.492149292 kegg kegg NA NA no no no no no up Sphingolipid metabolism Cushing syndrome 0 0 -0.444015444 kegg kegg NA NA no no no no no up Sphingolipid signaling pathway Cushing syndrome 0 -0.54743083 0 kegg kegg NA NA no no no no no up Spliceosome Cushing syndrome 0 0.443675889 0.439382239 kegg kegg NA NA no no no no no up Starch and sucrose metabolism Cushing syndrome -0.606086957 -0.468379447 -0.689317889 kegg kegg NA NA no no no no no up Synaptic vesicle cycle Cushing syndrome -0.453043478 -0.7756917 -0.698841699 kegg kegg NA NA no up up no no up Taurine and hypotaurine metabolism Cushing syndrome 0 0.469367589 0 kegg kegg NA NA no no no no no up Thermogenesis Cushing syndrome 0.537391304 0.43972332 0 kegg kegg NA NA no no no no no up Thyroid hormone synthesis Cushing syndrome 0.722608696 0.824110672 0.404375804 kegg kegg NA NA no no no no no up Tight junction Cushing syndrome 0 0 -0.502187902 kegg kegg NA NA no no no no no up Tryptophan metabolism Cushing syndrome 0 0 -0.445817246 kegg kegg NA NA no up no no no up Ubiquitin mediated proteolysis Cushing syndrome 0.649565217 0.668972332 0 kegg kegg NA NA no no no no no up Vascular smooth muscle contraction Cushing syndrome 0.602608696 0 0.401029601 kegg kegg NA NA no no no no no up Wnt signaling pathway Cushing syndrome 0.542608696 0.52173913 0 kegg kegg NA NA no no no no no up "Alanine, aspartate and glutamate metabolism" Cysteine and methionine metabolism 0 -0.615612648 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Cysteine and methionine metabolism 0 -0.608695652 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Cysteine and methionine metabolism 0.689565217 0.889328063 0.538223938 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Cysteine and methionine metabolism 0 -0.598814229 0 kegg kegg NA NA no no no no no no Fatty acid elongation Cysteine and methionine metabolism 0 0.691699605 0.611325611 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Cysteine and methionine metabolism 0 -0.571146245 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Cysteine and methionine metabolism 0.58173913 0.831027668 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Cysteine and methionine metabolism 0 0.46541502 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Cysteine and methionine metabolism 0.73826087 0.817193676 0.566023166 kegg kegg NA NA no no no no no no Pentose phosphate pathway Cysteine and methionine metabolism 0 -0.425889328 -0.489317889 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Cysteine and methionine metabolism 0.686956522 0.714426877 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Cysteine and methionine metabolism 0.406086957 0.563241107 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Cysteine and methionine metabolism 0 0.72826087 0.552638353 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Cysteine and methionine metabolism 0.546956522 0.652173913 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Cysteine and methionine metabolism 0.813043478 0.739130435 0.582239382 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Cysteine and methionine metabolism 0.599130435 0.695652174 0.577863578 kegg kegg NA NA no no no no no no 14:0/20:4-PC+blood Cysteine+blood 0 0 -0.492649573 yes serum_phospholipids serum_aminoacids 0.486 1.81E-07 no no no dn up up 14:1/18:2-PG+blood Cysteine+blood 0 0.571078431 0 yes serum_phospholipids serum_aminoacids 0.00259 1.81E-07 no up up dn up up 16:0-LPE+blood Cysteine+blood -0.497744361 0 0 yes serum_phospholipids serum_aminoacids 0.0711 1.81E-07 up up no dn up up 16:0/18:0-PS+blood Cysteine+blood -0.461654135 0 0 yes serum_phospholipids serum_aminoacids 0.377 1.81E-07 no no no dn up up 16:0/18:1-PC+blood Cysteine+blood 0 0 0.540512821 yes serum_phospholipids serum_aminoacids 6.15E-07 1.81E-07 up up up dn up up 16:0/18:2-PC+blood Cysteine+blood 0 0 0.513846154 yes serum_phospholipids serum_aminoacids 3.24E-06 1.81E-07 no up up dn up up 16:0/20:3-PC+blood Cysteine+blood 0.545864662 0 0 yes serum_phospholipids serum_aminoacids 5.43E-06 1.81E-07 no up up dn up up 16:0/20:4-PC+blood Cysteine+blood 0.470676692 0 0 yes serum_phospholipids serum_aminoacids 0.0262 1.81E-07 no up no dn up up 16:0/20:4-PE+blood Cysteine+blood -0.562406015 0 0 yes serum_phospholipids serum_aminoacids 0.00139 1.81E-07 up up no dn up up 16:1/16:0-PC+blood Cysteine+blood 0 0 0.457777778 yes serum_phospholipids serum_aminoacids 0.0215 1.81E-07 no up up dn up up 18:0-LPA+blood Cysteine+blood 0 0.544117647 0 yes serum_phospholipids serum_aminoacids 0.0725 1.81E-07 no dn no dn up up 18:0-LPE+blood Cysteine+blood -0.538345865 0 0 yes serum_phospholipids serum_aminoacids 0.491 1.81E-07 no no no dn up up 18:0/16:0-PC+blood Cysteine+blood 0 0 0.494017094 yes serum_phospholipids serum_aminoacids 9.64E-07 1.81E-07 up up up dn up up 18:0/18:0-PE+blood Cysteine+blood -0.49924812 0 -0.411282051 yes serum_phospholipids serum_aminoacids 0.00896 1.81E-07 up up no dn up up 18:0/18:1-PE+blood Cysteine+blood -0.530827068 0 0 yes serum_phospholipids serum_aminoacids 0.00716 1.81E-07 up up no dn up up 18:0/18:2-PC+blood Cysteine+blood 0 0 0.40991453 yes serum_phospholipids serum_aminoacids 1.74E-06 1.81E-07 no up up dn up up 18:0/20:4-PC+blood Cysteine+blood 0.466165414 0 0 yes serum_phospholipids serum_aminoacids 0.454 1.81E-07 no no no dn up up 18:1-LPE+blood Cysteine+blood -0.497744361 0 0 yes serum_phospholipids serum_aminoacids 0.117 1.81E-07 no no no dn up up 18:1/16:0-PC+blood Cysteine+blood 0 0 0.509059829 yes serum_phospholipids serum_aminoacids 2.43E-05 1.81E-07 no up up dn up up 18:1/16:0-PE+blood Cysteine+blood -0.586466165 0 0 yes serum_phospholipids serum_aminoacids 0.000182 1.81E-07 up up no dn up up 18:1/16:1-PE+blood Cysteine+blood -0.458646617 0 0 yes serum_phospholipids serum_aminoacids 0.000184 1.81E-07 up up no dn up up 18:1/18:0-PE+blood Cysteine+blood -0.484210526 0 0 yes serum_phospholipids serum_aminoacids 1.39E-06 1.81E-07 up up no dn up up 18:1/18:2-PE+blood Cysteine+blood 0 0 -0.404444444 yes serum_phospholipids serum_aminoacids 0.000293 1.81E-07 up up no dn up up 18:1/18:2-PI+blood Cysteine+blood 0.518796992 0 0 yes serum_phospholipids serum_aminoacids 0.0164 1.81E-07 dn no up dn up up 18:1/20:3-PC+blood Cysteine+blood 0.491729323 0 0 yes serum_phospholipids serum_aminoacids 0.00872 1.81E-07 no up up dn up up 18:1/20:4-PI+blood Cysteine+blood 0.610526316 0 0 yes serum_phospholipids serum_aminoacids 0.192 1.81E-07 no no no dn up up 18:1+blood Cysteine+blood 0 0 0.47965812 yes yes serum_fattyacid serum_aminoacids 0.00202 1.81E-07 up no dn dn up up 18:2/18:2-PS+blood Cysteine+blood -0.536842105 0 0 yes serum_phospholipids serum_aminoacids 0.00674 1.81E-07 up up no dn up up 18:3-LPC+blood Cysteine+blood 0 -0.524509804 -0.414017094 yes serum_phospholipids serum_aminoacids 0.147 1.81E-07 no no no dn up up 18:3/16:0-PE+blood Cysteine+blood -0.523308271 0 0 yes serum_phospholipids serum_aminoacids 0.00149 1.81E-07 up up no dn up up 20:1-LPA+blood Cysteine+blood 0.44962406 0 0 yes serum_phospholipids serum_aminoacids 0.0187 1.81E-07 dn dn no dn up up 20:2-LPC+blood Cysteine+blood 0.467669173 0 0 yes serum_phospholipids serum_aminoacids 0.119 1.81E-07 no no up dn up up 20:2+blood Cysteine+blood 0 0.593137255 0.465982906 yes serum_fattyacid serum_aminoacids 0.478 1.81E-07 no no no dn up up 20:4/16:0-PE+blood Cysteine+blood 0 0 -0.588376068 yes serum_phospholipids serum_aminoacids 0.00529 1.81E-07 no up up dn up up 20:5-LPC+blood Cysteine+blood 0 -0.568627451 0 yes serum_phospholipids serum_aminoacids 0.558 1.81E-07 no no no dn up up 20:5/18:0-PC+blood Cysteine+blood 0.497744361 0 0 yes serum_phospholipids serum_aminoacids 3.97E-06 1.81E-07 no up up dn up up 22:1-LPA+blood Cysteine+blood 0 0.580882353 0 yes serum_phospholipids serum_aminoacids 0.00373 1.81E-07 no up up dn up up 22:2-LPA+blood Cysteine+blood 0 0.644607843 0 yes serum_phospholipids serum_aminoacids 0.0443 1.81E-07 dn no no dn up up 4-hydroxybenzoic acid+stool Cysteine+blood 0.648351648 0 0 yes stool_cometabolism serum_aminoacids 0.0536 1.81E-07 no dn no dn up up 9-HODE+blood Cysteine+blood 0.454135338 0 0 yes serum_ARA serum_aminoacids 0.297 1.81E-07 no no no dn up up Acetic acid+stool Cysteine+blood 0 0 -0.45112782 yes yes stool_scfa serum_aminoacids 0.0656 1.81E-07 dn no no dn up up Acute myeloid leukemia Cysteine+blood 0 0.508823529 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Adrenergic signaling in cardiomyocytes Cysteine+blood 0 -0.623529412 0 yes kegg serum_aminoacids NA 1.81E-07 no no up dn up up AGE-RAGE signaling pathway in diabetic complications Cysteine+blood 0 0.538235294 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Alcoholism Cysteine+blood 0 0.638235294 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Aldosterone synthesis and secretion Cysteine+blood 0 -0.635294118 0 yes kegg serum_aminoacids NA 1.81E-07 no up up dn up up Allograft rejection Cysteine+blood 0 0.588235294 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Alzheimer disease Cysteine+blood 0 0 -0.401538462 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Amoebiasis Cysteine+blood 0 0.608823529 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Amphetamine addiction Cysteine+blood 0 -0.591176471 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Amyotrophic lateral sclerosis Cysteine+blood 0 0 -0.528461538 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Apelin signaling pathway Cysteine+blood 0 -0.605882353 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Apoptosis Cysteine+blood 0 0.541176471 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Arginine and proline metabolism Cysteine+blood 0 0 0.623076923 yes kegg serum_aminoacids NA 1.81E-07 no up no dn up up Autoimmune thyroid disease Cysteine+blood 0 0.588235294 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Biosynthesis of amino acids Cysteine+blood 0 0.794117647 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Bladder cancer Cysteine+blood 0 0.505882353 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up CA+blood Cysteine+blood 0 -0.556713777 -0.565011901 yes serum_bileacids serum_aminoacids 0.606 1.81E-07 no no no dn up up Calcium signaling pathway Cysteine+blood 0 0 -0.401538462 yes kegg serum_aminoacids NA 1.81E-07 no up up dn up up Cardiac muscle contraction Cysteine+blood 0 0 -0.46 yes kegg serum_aminoacids NA 1.81E-07 no no up dn up up CDCA+blood Cysteine+blood 0 -0.529411765 -0.503589744 yes serum_bileacids serum_aminoacids 0.506 1.81E-07 no no no dn up up Cell adhesion molecules Cysteine+blood 0 0.576470588 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Cell cycle Cysteine+blood 0 -0.811764706 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Cellular senescence Cysteine+blood 0 0.629411765 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up cGMP-PKG signaling pathway Cysteine+blood 0 0.814705882 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Chemical carcinogenesis - receptor activation Cysteine+blood 0 -0.523529412 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Chemokine signaling pathway Cysteine+blood 0 0.620588235 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Clostridium Cysteine+blood 0 0.497854171 0 yes Genus serum_aminoacids 0.925 1.81E-07 no no no dn up up Creatinine+blood Cysteine+blood 0.446616541 0 0.490598291 yes serum_choline serum_aminoacids 0.437 1.81E-07 no no no dn up up Cushing syndrome Cysteine+blood 0 -0.65 0 yes kegg serum_aminoacids NA 1.81E-07 no no up dn up up Cytokine-cytokine receptor interaction Cysteine+blood 0 0.638235294 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up EGFR tyrosine kinase inhibitor resistance Cysteine+blood 0 -0.620588235 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Endocytosis Cysteine+blood 0 0.664705882 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Epithelial cell signaling in Helicobacter pylori infection Cysteine+blood 0 0.552941176 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Faecalibacterium Cysteine+blood 0 0 -0.441442988 butyrate-producing yes Genus serum_aminoacids 0.0039 1.81E-07 no dn dn dn up up Fc epsilon RI signaling pathway Cysteine+blood 0 0.561764706 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Fc gamma R-mediated phagocytosis Cysteine+blood 0 0.744117647 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Gemmiger Cysteine+blood -0.45112782 0 0 butyrate-producing yes Genus serum_aminoacids 0.595 1.81E-07 no no no dn up up Glucagon signaling pathway Cysteine+blood 0 -0.629411765 -0.428461538 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Graft-versus-host disease Cysteine+blood 0 0.588235294 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up HCA+stool Cysteine+blood 0 0 -0.45112782 yes stool_bileacids serum_aminoacids 0.155 1.81E-07 no no no dn up up HDCA+stool Cysteine+blood 0 -0.636363636 0 yes stool_bileacids serum_aminoacids 0.176 1.81E-07 no no no dn up up Hippo signaling pathway Cysteine+blood 0 0 -0.431538462 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Human papillomavirus infection Cysteine+blood 0 0.602941176 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Huntington disease Cysteine+blood 0 0 -0.407692308 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up IL-17 signaling pathway Cysteine+blood 0 0.823529412 0.44 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Influenza A Cysteine+blood 0 0.529411765 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Insulin signaling pathway Cysteine+blood 0 -0.605882353 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up L-Phenylalanine+stool Cysteine+blood 0 0 0.44962406 yes stool_cometabolism serum_aminoacids 0.398 1.81E-07 no no no dn up up Lipid and atherosclerosis Cysteine+blood 0 0.708823529 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Long-term potentiation Cysteine+blood 0 -0.576470588 0 yes kegg serum_aminoacids NA 1.81E-07 no no up dn up up Lysosome Cysteine+blood 0 0.841176471 0.435384615 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Measles Cysteine+blood 0 -0.508823529 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up mRNA surveillance pathway Cysteine+blood 0 -0.808823529 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up mTOR signaling pathway Cysteine+blood 0 -0.658823529 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Natural killer cell mediated cytotoxicity Cysteine+blood 0 0.611764706 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Neuroactive ligand-receptor interaction Cysteine+blood 0 0.8 0 yes kegg serum_aminoacids NA 1.81E-07 up up up dn up up Neutrophil extracellular trap formation Cysteine+blood 0 0.814705882 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Nicotinate and nicotinamide metabolism Cysteine+blood 0 0.591176471 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Non-alcoholic fatty liver disease Cysteine+blood 0 0 -0.483846154 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Olfactory transduction Cysteine+blood 0 0.752941176 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Osteoclast differentiation Cysteine+blood 0 0.641176471 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Oxytocin signaling pathway Cysteine+blood 0 0.529411765 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Pathogenic Escherichia coli infection Cysteine+blood 0 0.667647059 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Peroxisome Cysteine+blood 0 0.623529412 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Pertussis Cysteine+blood 0 0.852941176 0 yes kegg serum_aminoacids NA 1.81E-07 no no dn dn up up Phagosome Cysteine+blood 0 0.711764706 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Phenylacetic acid+stool Cysteine+blood 0 0 0.57443609 yes stool_cometabolism serum_aminoacids 0.785 1.81E-07 no no no dn up up PI3K-Akt signaling pathway Cysteine+blood 0 -0.635294118 0 yes yes kegg serum_aminoacids NA 1.81E-07 no up up dn up up Primary immunodeficiency Cysteine+blood 0 -0.614705882 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Prion disease Cysteine+blood 0 0 -0.413076923 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Progesterone-mediated oocyte maturation Cysteine+blood 0 -0.567647059 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Prolactin signaling pathway Cysteine+blood 0 0.538235294 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Proteasome Cysteine+blood 0 0 0.462307692 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Protein processing in endoplasmic reticulum Cysteine+blood 0 -0.744117647 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Proteoglycans in cancer Cysteine+blood 0 -0.502941176 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Rheumatoid arthritis Cysteine+blood 0 0.735294118 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Ribosome biogenesis in eukaryotes Cysteine+blood 0 -0.770588235 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up RNA degradation Cysteine+blood 0 -0.652941176 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up RNA transport Cysteine+blood 0 -0.6 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Slackia Cysteine+blood 0 0 -0.405914191 yes Genus serum_aminoacids 0.94 1.81E-07 no no no dn up up Spinocerebellar ataxia Cysteine+blood 0 -0.711764706 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Spliceosome Cysteine+blood 0 -0.602941176 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Staphylococcus aureus infection Cysteine+blood 0 0.717647059 0 yes kegg serum_aminoacids NA 1.81E-07 up no no dn up up Systemic lupus erythematosus Cysteine+blood 0 0.794117647 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Tuberculosis Cysteine+blood 0 0.75 0 yes kegg serum_aminoacids NA 1.81E-07 no no dn dn up up Type I diabetes mellitus Cysteine+blood 0 0.588235294 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Ubiquitin mediated proteolysis Cysteine+blood 0 -0.505882353 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Viral carcinogenesis Cysteine+blood 0 0.541176471 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Viral myocarditis Cysteine+blood 0 0.538235294 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Viral protein interaction with cytokine and cytokine receptor Cysteine+blood 0 0.752941176 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Wnt signaling pathway Cysteine+blood 0 -0.697058824 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up Yersinia infection Cysteine+blood 0 0.685294118 0 yes kegg serum_aminoacids NA 1.81E-07 no no no dn up up 12-HEPE+blood Cystine+blood 0 -0.507149988 0 yes serum_ARA serum_aminoacids 0.312 0.00028 no no no up up no 12-ketoDCA+stool Cystine+blood -0.582417582 0 0 yes stool_bileacids serum_aminoacids 0.505 0.00028 no no no up up no 14:0/18:2-PC+blood Cystine+blood -0.482706767 0 -0.461880342 yes serum_phospholipids serum_aminoacids 0.102 0.00028 no up no up up no 14:0/20:4-PC+blood Cystine+blood 0 0 -0.405811966 yes serum_phospholipids serum_aminoacids 0.486 0.00028 no no no up up no 15-HETE+blood Cystine+blood 0.513651104 0 0 yes serum_ARA serum_aminoacids 0.819 0.00028 no no no up up no 16:0/18:0-PS+blood Cystine+blood -0.464661654 0 0 yes serum_phospholipids serum_aminoacids 0.377 0.00028 no no no up up no 16:0/18:1-PC+blood Cystine+blood 0 0 0.456410256 yes serum_phospholipids serum_aminoacids 6.15E-07 0.00028 up up up up up no 16:0/18:1-PE+blood Cystine+blood -0.445112782 0 0 yes serum_phospholipids serum_aminoacids 0.000107 0.00028 up up no up up no 16:0/18:2-PC+blood Cystine+blood 0 0.642156863 0 yes serum_phospholipids serum_aminoacids 3.24E-06 0.00028 no up up up up no 16:0/20:4-PI+blood Cystine+blood 0 -0.50245098 0 yes serum_phospholipids serum_aminoacids 0.558 0.00028 no no no up up no 16:0/20:5-PC+blood Cystine+blood 0 -0.642156863 0 yes serum_phospholipids serum_aminoacids 0.628 0.00028 no no no up up no 18:0-LPC+blood Cystine+blood -0.472180451 0 0 yes serum_phospholipids serum_aminoacids 0.554 0.00028 no no no up up no 18:0-LPE+blood Cystine+blood -0.472180451 0 0 yes serum_phospholipids serum_aminoacids 0.491 0.00028 no no no up up no 18:0/16:0-PC+blood Cystine+blood 0 0.49754902 0.439316239 yes serum_phospholipids serum_aminoacids 9.64E-07 0.00028 up up up up up no 18:0/18:0-PE+blood Cystine+blood 0 0 -0.543247863 yes serum_phospholipids serum_aminoacids 0.00896 0.00028 up up no up up no 18:0/18:1-PE+blood Cystine+blood 0 0 -0.442735043 yes serum_phospholipids serum_aminoacids 0.00716 0.00028 up up no up up no 18:0/18:1-PI+blood Cystine+blood -0.452631579 0 0 yes serum_phospholipids serum_aminoacids 0.599 0.00028 no no no up up no 18:0/18:2-PI+blood Cystine+blood -0.44962406 0 0 yes serum_phospholipids serum_aminoacids 0.179 0.00028 no no no up up no 18:0/20:5-PC+blood Cystine+blood 0.497744361 0 0 yes serum_phospholipids serum_aminoacids 0.17 0.00028 no no no up up no 18:1/16:0-PC+blood Cystine+blood 0 0.642156863 0 yes serum_phospholipids serum_aminoacids 2.43E-05 0.00028 no up up up up no 18:1/16:0-PE+blood Cystine+blood -0.509774436 0 -0.451623932 yes serum_phospholipids serum_aminoacids 0.000182 0.00028 up up no up up no 18:1/16:0-PI+blood Cystine+blood -0.541353383 0 0 yes serum_phospholipids serum_aminoacids 0.793 0.00028 no no no up up no 18:1/16:1-PE+blood Cystine+blood -0.484210526 0 0 yes serum_phospholipids serum_aminoacids 0.000184 0.00028 up up no up up no 18:1/18:0-PE+blood Cystine+blood -0.44962406 0 0 yes serum_phospholipids serum_aminoacids 1.39E-06 0.00028 up up no up up no 18:1/18:1-PE+blood Cystine+blood -0.556390977 0 0 yes serum_phospholipids serum_aminoacids 1.03E-05 0.00028 up up no up up no 18:1/18:1-PG+blood Cystine+blood 0 0 0.540512821 yes serum_phospholipids serum_aminoacids 0.00352 0.00028 no up up up up no 18:1/18:2-PI+blood Cystine+blood 0 0 -0.401025641 yes serum_phospholipids serum_aminoacids 0.0164 0.00028 dn no up up up no 18:2/18:2-PS+blood Cystine+blood -0.503759398 0 0 yes serum_phospholipids serum_aminoacids 0.00674 0.00028 up up no up up no 18:3/16:0-PE+blood Cystine+blood -0.45112782 0 0 yes serum_phospholipids serum_aminoacids 0.00149 0.00028 up up no up up no 18:3/18:2-PC+blood Cystine+blood 0 -0.546568627 0 yes serum_phospholipids serum_aminoacids 0.0394 0.00028 no no up up up no 20:0/20:4-PE+blood Cystine+blood 0 0 -0.424957265 yes serum_phospholipids serum_aminoacids 0.00128 0.00028 up up no up up no 20:2/18:1-PE+blood Cystine+blood -0.538345865 0 0 yes serum_phospholipids serum_aminoacids 0.00208 0.00028 up up no up up no 20:4/16:0-PE+blood Cystine+blood 0 0 -0.612307692 yes serum_phospholipids serum_aminoacids 0.00529 0.00028 no up up up up no 24:1+blood Cystine+blood 0.485714286 0 0.406495726 yes serum_fattyacid serum_aminoacids 0.00582 0.00028 no dn dn up up no Acute myeloid leukemia Cystine+blood 0.512280702 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no AGE-RAGE signaling pathway in diabetic complications Cystine+blood 0.492982456 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Allograft rejection Cystine+blood 0.547368421 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Amoebiasis Cystine+blood 0.478947368 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no AMPK signaling pathway Cystine+blood 0 0 -0.502307692 yes kegg serum_aminoacids NA 0.00028 no no no up up no Arginine and proline metabolism Cystine+blood 0 0 0.523076923 yes kegg serum_aminoacids NA 0.00028 no up no up up no Asthma Cystine+blood 0.5 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Autoimmune thyroid disease Cystine+blood 0.547368421 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Blautia Cystine+blood 0 0.580882353 0 acetate-producing yes Genus serum_aminoacids 1.36E-05 0.00028 up dn dn up up no butyric acid C4+blood Cystine+blood 0.494736842 0 0 yes serum_scfa serum_aminoacids 0.407 0.00028 no no no up up no capric acid C6+blood Cystine+blood -0.464661654 0 0 yes serum_scfa serum_aminoacids 0.433 0.00028 no no no up up no Cell cycle Cystine+blood -0.778947368 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Cellular senescence Cystine+blood 0.549122807 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Creatinine+blood Cystine+blood 0 0.590686275 0 yes serum_choline serum_aminoacids 0.437 0.00028 no no no up up no Cysteine+blood Cystine+blood 0 0 0.597948718 yes yes serum_aminoacids serum_aminoacids 1.81E-07 0.00028 dn up up up up no DCA+stool Cystine+blood 0 0 -0.457142857 yes stool_bileacids serum_aminoacids 0.195 0.00028 no no no up up no Endocrine resistance Cystine+blood 0 0 -0.415384615 yes kegg serum_aminoacids NA 0.00028 no no no up up no Endocytosis Cystine+blood 0.51754386 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Estrogen signaling pathway Cystine+blood -0.557894737 0 -0.564615385 yes kegg serum_aminoacids NA 0.00028 no no no up up no Ferroptosis Cystine+blood 0.545614035 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Gap junction Cystine+blood 0 0 -0.406923077 yes kegg serum_aminoacids NA 0.00028 no no no up up no GCDCA+stool Cystine+blood 0 0.636363636 0 yes yes stool_bileacids serum_aminoacids 0.0471 0.00028 no dn no up up no Graft-versus-host disease Cystine+blood 0.519298246 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Human papillomavirus infection Cystine+blood 0.587719298 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Influenza A Cystine+blood 0.675438596 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no LCA+stool Cystine+blood 0 0 -0.482706767 yes stool_bileacids serum_aminoacids 0.314 0.00028 no no no up up no Legionellosis Cystine+blood -0.531578947 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Longevity regulating pathway Cystine+blood 0 0 -0.412307692 yes kegg serum_aminoacids NA 0.00028 no no no up up no Lysosome Cystine+blood 0.521052632 0 0.463846154 yes kegg serum_aminoacids NA 0.00028 no no no up up no Malaria Cystine+blood 0.496491228 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Methanobrevibacter Cystine+blood 0 -0.516353281 0 yes Genus serum_aminoacids 0.629 0.00028 no no no up up no Oocyte meiosis Cystine+blood -0.510526316 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Pancreatic cancer Cystine+blood 0 0 -0.449230769 yes kegg serum_aminoacids NA 0.00028 no no no up up no Phagosome Cystine+blood 0.521052632 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Phenylacetic acid+stool Cystine+blood 0 -0.609090909 0 yes stool_cometabolism serum_aminoacids 0.785 0.00028 no no no up up no Phospholipase D signaling pathway Cystine+blood 0.461403509 0 0 yes kegg serum_aminoacids NA 0.00028 no up up up up no PI3K-Akt signaling pathway Cystine+blood -0.554385965 0 0 yes yes kegg serum_aminoacids NA 0.00028 no up up up up no Primary immunodeficiency Cystine+blood -0.533333333 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Progesterone-mediated oocyte maturation Cystine+blood -0.478947368 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Proteasome Cystine+blood 0 0 0.435384615 yes kegg serum_aminoacids NA 0.00028 no no no up up no Rheumatoid arthritis Cystine+blood 0.473684211 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Ribosome biogenesis in eukaryotes Cystine+blood -0.571929825 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no RNA transport Cystine+blood -0.668421053 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Slackia Cystine+blood 0 0 -0.553971019 yes Genus serum_aminoacids 0.94 0.00028 no no no up up no Spliceosome Cystine+blood -0.571929825 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no T cell receptor signaling pathway Cystine+blood -0.473684211 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Type I diabetes mellitus Cystine+blood 0.547368421 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Viral carcinogenesis Cystine+blood 0.538596491 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Viral myocarditis Cystine+blood 0.542105263 0 0 yes kegg serum_aminoacids NA 0.00028 no no no up up no Akkermansia Cytokine-cytokine receptor interaction 0 -0.522639678 0 acetate-producing Genus kegg 0.23 NA no no no no no no alpha-Linolenic acid metabolism Cytokine-cytokine receptor interaction 0 0.46541502 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Cytokine-cytokine receptor interaction 0 0.433794466 0 kegg kegg NA NA no no no no no no Bacteroides Cytokine-cytokine receptor interaction 0 0 0.402574003 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Biosynthesis of amino acids Cytokine-cytokine receptor interaction 0 0.505928854 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Cytokine-cytokine receptor interaction 0 0.548418972 0.424195624 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Cytokine-cytokine receptor interaction 0 0.543478261 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Cytokine-cytokine receptor interaction 0 0.468379447 0 kegg kegg NA NA no no no no no no Fatty acid elongation Cytokine-cytokine receptor interaction 0 0.470355731 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Cytokine-cytokine receptor interaction 0 0.550395257 0 kegg kegg NA NA no no no no no no Folate biosynthesis Cytokine-cytokine receptor interaction 0 -0.517786561 0 kegg kegg NA NA no no no no no no Glutathione metabolism Cytokine-cytokine receptor interaction -0.406086957 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Cytokine-cytokine receptor interaction 0 -0.532608696 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Cytokine-cytokine receptor interaction -0.408695652 0 0 kegg kegg NA NA no no no no no no Lysine degradation Cytokine-cytokine receptor interaction 0 -0.546442688 -0.455083655 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Cytokine-cytokine receptor interaction 0 -0.613636364 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Cytokine-cytokine receptor interaction 0 -0.720355731 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Cytokine-cytokine receptor interaction 0 0.451581028 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Cytokine-cytokine receptor interaction 0 -0.418972332 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Cytokine-cytokine receptor interaction 0 -0.418972332 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Cytokine-cytokine receptor interaction 0.443478261 0.551383399 0 kegg kegg NA NA no no dn no no no Pentose phosphate pathway Cytokine-cytokine receptor interaction 0 0.586956522 0 kegg kegg NA NA no no no no no no Protein export Cytokine-cytokine receptor interaction 0 -0.460474308 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Cytokine-cytokine receptor interaction 0 0 0.563963964 kegg kegg NA NA no no no no no no RNA degradation Cytokine-cytokine receptor interaction 0 -0.531620553 0 kegg kegg NA NA no no no no no no RNA polymerase Cytokine-cytokine receptor interaction 0 -0.419960474 0 kegg kegg NA NA no no no no no no Sulfur metabolism Cytokine-cytokine receptor interaction -0.442608696 0 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Cytokine-cytokine receptor interaction 0 0 0.431145431 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Cytosolic DNA-sensing pathway 0 -0.454545455 -0.626512227 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Cytosolic DNA-sensing pathway 0 -0.437747036 0 kegg kegg NA NA no no no no no no Antifolate resistance Cytosolic DNA-sensing pathway 0 -0.48715415 0 kegg kegg NA NA no no no no no no Apoptosis Cytosolic DNA-sensing pathway 0.433043478 0.508893281 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Cytosolic DNA-sensing pathway -0.509565217 0 -0.662033462 kegg kegg NA NA no no no no no no Autophagy - animal Cytosolic DNA-sensing pathway 0 0.517786561 0 kegg kegg NA NA no no no no no no Autophagy - other Cytosolic DNA-sensing pathway 0 0.423913043 0 kegg kegg NA NA no no no no no no Base excision repair Cytosolic DNA-sensing pathway 0 0 -0.527927928 kegg kegg NA NA no no no no no no beta-Alanine metabolism Cytosolic DNA-sensing pathway 0 -0.636363636 -0.59047619 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Cytosolic DNA-sensing pathway 0 -0.613636364 -0.571943372 kegg kegg NA NA no no no no no no Butanoate metabolism Cytosolic DNA-sensing pathway 0 -0.576086957 -0.435263835 kegg kegg NA NA no no no no no no cAMP signaling pathway Cytosolic DNA-sensing pathway 0 0.796442688 0.598198198 yes kegg kegg NA NA no up up no no no Cellular senescence Cytosolic DNA-sensing pathway 0 0.444664032 0.608751609 kegg kegg NA NA no no no no no no Chemokine signaling pathway Cytosolic DNA-sensing pathway 0.529565217 0 0.584298584 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Cytosolic DNA-sensing pathway 0 -0.550395257 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Cytosolic DNA-sensing pathway 0 -0.544466403 -0.429343629 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Cytosolic DNA-sensing pathway 0 -0.414031621 0 kegg kegg NA NA no no no no no no DNA replication Cytosolic DNA-sensing pathway -0.419130435 -0.59486166 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Cytosolic DNA-sensing pathway 0 -0.570158103 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Cytosolic DNA-sensing pathway 0 -0.41798419 0 kegg kegg NA NA no no no no no no Endocytosis Cytosolic DNA-sensing pathway 0 0 0.550836551 kegg kegg NA NA no no no no no no Fanconi anemia pathway Cytosolic DNA-sensing pathway 0 -0.429841897 -0.459202059 kegg kegg NA NA no no no no no no Fatty acid elongation Cytosolic DNA-sensing pathway 0 -0.546442688 -0.533075933 kegg kegg NA NA no no no no no no Focal adhesion Cytosolic DNA-sensing pathway 0 -0.436758893 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Cytosolic DNA-sensing pathway 0 0 -0.629086229 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Cytosolic DNA-sensing pathway 0 0 -0.485714286 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Cytosolic DNA-sensing pathway 0 0.437747036 0 kegg kegg NA NA no no no no no no Histidine metabolism Cytosolic DNA-sensing pathway 0 -0.433794466 -0.599485199 kegg kegg NA NA no no no no no no Homologous recombination Cytosolic DNA-sensing pathway 0 0 -0.534105534 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Cytosolic DNA-sensing pathway 0 0 -0.468725869 kegg kegg NA NA no no no no no no Lachnospira Cytosolic DNA-sensing pathway 0 -0.416604905 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Longevity regulating pathway - multiple species Cytosolic DNA-sensing pathway -0.494782609 0 -0.414414414 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Cytosolic DNA-sensing pathway 0 -0.599802372 0 kegg kegg NA NA no no no no no no Mismatch repair Cytosolic DNA-sensing pathway 0 -0.711462451 -0.421879022 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Cytosolic DNA-sensing pathway 0 0.597826087 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway 0 0.520750988 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Cytosolic DNA-sensing pathway 0 -0.652173913 -0.443243243 kegg kegg NA NA no no no no no no Nucleotide excision repair Cytosolic DNA-sensing pathway -0.475652174 -0.640316206 -0.516602317 kegg kegg NA NA no no no no no no One carbon pool by folate Cytosolic DNA-sensing pathway -0.50173913 -0.710474308 0 kegg kegg NA NA no no no no no no Oocyte meiosis Cytosolic DNA-sensing pathway 0 -0.428853755 0 kegg kegg NA NA no no no no no no p53 signaling pathway Cytosolic DNA-sensing pathway 0 0 -0.446846847 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Cytosolic DNA-sensing pathway 0 -0.420948617 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Cytosolic DNA-sensing pathway 0 -0.654150198 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Cytosolic DNA-sensing pathway 0 -0.424901186 0 kegg kegg NA NA no no no no no no Platinum drug resistance Cytosolic DNA-sensing pathway -0.452173913 0 -0.645045045 kegg kegg NA NA no no no no no no PPAR signaling pathway Cytosolic DNA-sensing pathway 0 0.52173913 0.445302445 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Cytosolic DNA-sensing pathway -0.445217391 -0.571146245 -0.52998713 kegg kegg NA NA no no no no no no Propanoate metabolism Cytosolic DNA-sensing pathway 0 -0.546442688 -0.427284427 kegg kegg NA NA no no no no no no Pyrimidine metabolism Cytosolic DNA-sensing pathway 0 -0.627470356 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Cytosolic DNA-sensing pathway -0.409565217 -0.514822134 -0.505534106 kegg kegg NA NA no no no no no no Retinol metabolism Cytosolic DNA-sensing pathway 0 -0.735177866 -0.519433719 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Cytosolic DNA-sensing pathway 0 -0.432806324 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway 0 0.658102767 0.447104247 kegg kegg NA NA no no no no no no Selenocompound metabolism Cytosolic DNA-sensing pathway 0 0 -0.553667954 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Cytosolic DNA-sensing pathway 0 0.495059289 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Cytosolic DNA-sensing pathway -0.453043478 -0.753952569 -0.472586873 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Cytosolic DNA-sensing pathway 0 -0.814229249 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Cytosolic DNA-sensing pathway 0 -0.652173913 -0.423938224 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Cytosolic DNA-sensing pathway 0.453913043 0.606719368 0.735907336 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Cytosolic DNA-sensing pathway 0 -0.700592885 -0.494208494 kegg kegg NA NA no up no no no no Tyrosine metabolism Cytosolic DNA-sensing pathway -0.427826087 -0.806324111 -0.567567568 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Cytosolic DNA-sensing pathway 0 -0.704545455 -0.40978121 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Cytosolic DNA-sensing pathway 0 -0.649209486 -0.513770914 kegg kegg NA NA no no no no no no 12-HEPE+blood d18:0-16:0-SM+blood 0 0 -0.436717961 serum_ARA serum_phospholipids 0.312 0.202 no no no no no no "12,13-EPOME+blood" d18:0-16:0-SM+blood 0 -0.711504645 0 serum_ARA serum_phospholipids 0.901 0.202 no no no no no no 16:0-LPC+blood d18:0-16:0-SM+blood 0 0.539215686 0 serum_phospholipids serum_phospholipids 0.00456 0.202 up up no no no no 16:0/18:2-PC+blood d18:0-16:0-SM+blood 0 0 -0.644444444 serum_phospholipids serum_phospholipids 3.24E-06 0.202 no up up no no no 16:0/20:3-PC+blood d18:0-16:0-SM+blood 0 -0.482843137 0 serum_phospholipids serum_phospholipids 5.43E-06 0.202 no up up no no no 16:0/20:5-PG+blood d18:0-16:0-SM+blood 0.55037594 0 0.568547009 serum_phospholipids serum_phospholipids 0.00656 0.202 no up no no no no 16:0/22:6-PC+blood d18:0-16:0-SM+blood 0 0 -0.578803419 serum_phospholipids serum_phospholipids 4.53E-05 0.202 no up up no no no 16:1/16:0-PC+blood d18:0-16:0-SM+blood 0 0 -0.648547009 serum_phospholipids serum_phospholipids 0.0215 0.202 no up up no no no 16:1/16:1-PC+blood d18:0-16:0-SM+blood 0 0 -0.472136752 serum_phospholipids serum_phospholipids 0.0177 0.202 no no up no no no 16:1/18:1-PG+blood d18:0-16:0-SM+blood 0 0 0.556239316 serum_phospholipids serum_phospholipids 3.21E-05 0.202 no up up no no no 16:1/18:2-PG+blood d18:0-16:0-SM+blood 0 0 0.448205128 serum_phospholipids serum_phospholipids 1.40E-08 0.202 no up up no no no 18:0/18:1-PI+blood d18:0-16:0-SM+blood 0 0 0.547350427 serum_phospholipids serum_phospholipids 0.599 0.202 no no no no no no 18:0/18:2-PC+blood d18:0-16:0-SM+blood 0 -0.588235294 -0.486495726 serum_phospholipids serum_phospholipids 1.74E-06 0.202 no up up no no no 18:0/18:2-PI+blood d18:0-16:0-SM+blood 0 0 0.496068376 serum_phospholipids serum_phospholipids 0.179 0.202 no no no no no no 18:0/22:6-PC+blood d18:0-16:0-SM+blood -0.446616541 0 -0.55008547 serum_phospholipids serum_phospholipids 0.0775 0.202 no no up no no no 18:1/16:0-PC+blood d18:0-16:0-SM+blood 0 0 -0.647863248 serum_phospholipids serum_phospholipids 2.43E-05 0.202 no up up no no no 18:1/18:0-PC+blood d18:0-16:0-SM+blood 0 -0.566176471 -0.512478632 serum_phospholipids serum_phospholipids 1.83E-06 0.202 no up up no no no 18:1/18:0-PI+blood d18:0-16:0-SM+blood 0 0 0.422222222 serum_phospholipids serum_phospholipids 0.0931 0.202 no no up no no no 18:1/18:1-PG+blood d18:0-16:0-SM+blood 0 0 0.593162393 serum_phospholipids serum_phospholipids 0.00352 0.202 no up up no no no 18:1/18:1-PI+blood d18:0-16:0-SM+blood 0 0 0.417435897 serum_phospholipids serum_phospholipids 0.111 0.202 dn no no no no no 18:1/18:2-PG+blood d18:0-16:0-SM+blood 0 0 0.473504274 serum_phospholipids serum_phospholipids 5.58E-07 0.202 no up up no no no 18:1/20:4-PE+blood d18:0-16:0-SM+blood 0.569924812 0 0 serum_phospholipids serum_phospholipids 0.0578 0.202 up no no no no no 18:1/22:6-PE+blood d18:0-16:0-SM+blood 0.487218045 0 0 serum_phospholipids serum_phospholipids 0.0047 0.202 no up no no no no 18:2/16:0-PC+blood d18:0-16:0-SM+blood 0 0 -0.437264957 serum_phospholipids serum_phospholipids 8.67E-05 0.202 no up up no no no 18:2/18:2-PS+blood d18:0-16:0-SM+blood 0 0 0.530940171 serum_phospholipids serum_phospholipids 0.00674 0.202 up up no no no no 18:3n3+blood d18:0-16:0-SM+blood 0 0 -0.40034188 serum_fattyacid serum_phospholipids 0.291 0.202 no no no no no no 18:3n6+blood d18:0-16:0-SM+blood 0 0 0.432478632 serum_fattyacid serum_phospholipids 0.0463 0.202 up no dn no no no 20:0/20:4-PE+blood d18:0-16:0-SM+blood 0.551879699 0 0.413333333 serum_phospholipids serum_phospholipids 0.00128 0.202 up up no no no no 20:1-LPA+blood d18:0-16:0-SM+blood 0 0 0.404444444 serum_phospholipids serum_phospholipids 0.0187 0.202 dn dn no no no no 20:1/20:4-PC+blood d18:0-16:0-SM+blood -0.473684211 0 -0.513162393 serum_phospholipids serum_phospholipids 0.0419 0.202 no no up no no no 20:1/20:4-PE+blood d18:0-16:0-SM+blood 0.769924812 0 0 serum_phospholipids serum_phospholipids 0.0042 0.202 up up no no no no 20:2/18:3-PE+blood d18:0-16:0-SM+blood 0.667669173 0 0 serum_phospholipids serum_phospholipids 0.0391 0.202 up up no no no no 20:4-LPC+blood d18:0-16:0-SM+blood 0 0 0.44957265 serum_phospholipids serum_phospholipids 0.949 0.202 no no no no no no 20:4-LPE+blood d18:0-16:0-SM+blood 0.508270677 0 0 serum_phospholipids serum_phospholipids 0.552 0.202 no no no no no no 20:4/18:0-PE+blood d18:0-16:0-SM+blood 0.484210526 0 0 serum_phospholipids serum_phospholipids 0.000755 0.202 up up no no no no 20:4n6+blood d18:0-16:0-SM+blood 0.529323308 0 0 serum_fattyacid serum_phospholipids 0.133 0.202 no no no no no no 20:5/18:0-PC+blood d18:0-16:0-SM+blood 0 0 -0.629401709 serum_phospholipids serum_phospholipids 3.97E-06 0.202 no up up no no no 24:0+blood d18:0-16:0-SM+blood 0.448120301 0 0 serum_fattyacid serum_phospholipids 0.034 0.202 dn no up no no no 8-HETE+blood d18:0-16:0-SM+blood 0.541353383 0 0 serum_ARA serum_phospholipids 0.741 0.202 no no no no no no Adrenergic signaling in cardiomyocytes d18:0-16:0-SM+blood 0 0 0.442307692 kegg serum_phospholipids NA 0.202 no no up no no no Aldosterone synthesis and secretion d18:0-16:0-SM+blood 0 0 0.46 kegg serum_phospholipids NA 0.202 no up up no no no Amphetamine addiction d18:0-16:0-SM+blood 0 0 0.463076923 kegg serum_phospholipids NA 0.202 no no no no no no Antigen processing and presentation d18:0-16:0-SM+blood 0 -0.617647059 0 kegg serum_phospholipids NA 0.202 no no no no no no Calcium signaling pathway d18:0-16:0-SM+blood 0 0 0.473846154 kegg serum_phospholipids NA 0.202 no up up no no no Choline metabolism in cancer d18:0-16:0-SM+blood 0 0.508823529 0 kegg serum_phospholipids NA 0.202 no no no no no no Clostridium d18:0-16:0-SM+blood -0.449793187 0 0 Genus serum_phospholipids 0.925 0.202 no no no no no no Cocaine addiction d18:0-16:0-SM+blood 0 0 0.437692308 kegg serum_phospholipids NA 0.202 no no no no no no Dopaminergic synapse d18:0-16:0-SM+blood 0 0 0.457692308 kegg serum_phospholipids NA 0.202 no up no no no no Epstein-Barr virus infection d18:0-16:0-SM+blood 0 -0.576470588 0 kegg serum_phospholipids NA 0.202 no no no no no no GDCA+stool d18:0-16:0-SM+blood 0.659340659 0 0 stool_bileacids serum_phospholipids 0.656 0.202 no no no no no no Gemmiger d18:0-16:0-SM+blood 0 0.496315994 0 butyrate-producing Genus serum_phospholipids 0.595 0.202 no no no no no no GnRH signaling pathway d18:0-16:0-SM+blood 0 0 0.463846154 kegg serum_phospholipids NA 0.202 no no no no no no Hematopoietic cell lineage d18:0-16:0-SM+blood -0.485964912 0 0 kegg serum_phospholipids NA 0.202 no no no no no no Herpes simplex virus 1 infection d18:0-16:0-SM+blood 0 -0.617647059 0 kegg serum_phospholipids NA 0.202 no no no no no no Human cytomegalovirus infection d18:0-16:0-SM+blood 0 -0.532352941 0 kegg serum_phospholipids NA 0.202 no no dn no no no Human immunodeficiency virus 1 infection d18:0-16:0-SM+blood 0 -0.544117647 0 kegg serum_phospholipids NA 0.202 no no no no no no Human T-cell leukemia virus 1 infection d18:0-16:0-SM+blood 0 -0.597058824 0 kegg serum_phospholipids NA 0.202 no no no no no no Inflammatory mediator regulation of TRP channels d18:0-16:0-SM+blood 0 0 0.443846154 kegg serum_phospholipids NA 0.202 no no no no no no Long-term depression d18:0-16:0-SM+blood 0 0 0.416923077 kegg serum_phospholipids NA 0.202 no no no no no no Longevity regulating pathway - multiple species d18:0-16:0-SM+blood 0 0 -0.41 kegg serum_phospholipids NA 0.202 no no no no no no Malaria d18:0-16:0-SM+blood -0.51754386 0 0 kegg serum_phospholipids NA 0.202 no no no no no no Melanogenesis d18:0-16:0-SM+blood 0 0 0.433076923 kegg serum_phospholipids NA 0.202 no no no no no no Mineral absorption d18:0-16:0-SM+blood -0.503508772 0 0 kegg serum_phospholipids NA 0.202 no no no no no no Pancreatic secretion d18:0-16:0-SM+blood 0 0 0.466153846 kegg serum_phospholipids NA 0.202 no no no no no no Peroxisome d18:0-16:0-SM+blood 0 0 -0.523076923 kegg serum_phospholipids NA 0.202 no no no no no no Retrograde endocannabinoid signaling d18:0-16:0-SM+blood 0.468421053 0 0 kegg serum_phospholipids NA 0.202 no no up no no no Ruminococcus d18:0-16:0-SM+blood 0 0 0.413286326 Genus serum_phospholipids 0.0679 0.202 no no dn no no no Signaling pathways regulating pluripotency of stem cells d18:0-16:0-SM+blood 0 0.514705882 0 kegg serum_phospholipids NA 0.202 no no no no no no Vasopressin-regulated water reabsorption d18:0-16:0-SM+blood 0 0 0.420769231 kegg serum_phospholipids NA 0.202 no no no no no no 11-HETE+blood d18:0-18:3-SM+blood 0 -0.616595352 0 serum_ARA serum_phospholipids 0.464 0.0879 no no no no dn no 14:0-LPC+blood d18:0-18:3-SM+blood -0.460150376 0 0 serum_phospholipids serum_phospholipids 0.00689 0.0879 up up no no dn no 14:0/20:4-PC+blood d18:0-18:3-SM+blood 0 0 0.585641026 serum_phospholipids serum_phospholipids 0.486 0.0879 no no no no dn no 16:0-LPC+blood d18:0-18:3-SM+blood 0 0.644607843 0 serum_phospholipids serum_phospholipids 0.00456 0.0879 up up no no dn no 16:0/16:1-PC+blood d18:0-18:3-SM+blood 0 -0.485294118 0 serum_phospholipids serum_phospholipids 0.00283 0.0879 up up no no dn no 16:0/18:0-PS+blood d18:0-18:3-SM+blood 0.461654135 0 0 serum_phospholipids serum_phospholipids 0.377 0.0879 no no no no dn no 16:0/18:1-PC+blood d18:0-18:3-SM+blood 0 0 -0.485128205 serum_phospholipids serum_phospholipids 6.15E-07 0.0879 up up up no dn no 16:0/18:1-PE+blood d18:0-18:3-SM+blood 0 -0.578431373 -0.403760684 serum_phospholipids serum_phospholipids 0.000107 0.0879 up up no no dn no 16:0/18:2-PC+blood d18:0-18:3-SM+blood 0 -0.49754902 -0.64034188 serum_phospholipids serum_phospholipids 3.24E-06 0.0879 no up up no dn no 16:0/18:3-PC+blood d18:0-18:3-SM+blood 0.461654135 0.556372549 0 serum_phospholipids serum_phospholipids 0.00216 0.0879 no up up no dn no 16:0/20:3-PC+blood d18:0-18:3-SM+blood 0 -0.526960784 0 serum_phospholipids serum_phospholipids 5.43E-06 0.0879 no up up no dn no 16:0/22:6-PE+blood d18:0-18:3-SM+blood 0.536842105 0 0 serum_phospholipids serum_phospholipids 0.000934 0.0879 up up no no dn no 18:0/16:0-PC+blood d18:0-18:3-SM+blood 0 0 -0.496068376 serum_phospholipids serum_phospholipids 9.64E-07 0.0879 up up up no dn no 18:0/20:3-PI+blood d18:0-18:3-SM+blood 0 -0.544117647 0 serum_phospholipids serum_phospholipids 0.377 0.0879 no no no no dn no 18:0/22:6-PC+blood d18:0-18:3-SM+blood 0 0 -0.425641026 serum_phospholipids serum_phospholipids 0.0775 0.0879 no no up no dn no 18:1/16:0-PC+blood d18:0-18:3-SM+blood 0 0 -0.632820513 serum_phospholipids serum_phospholipids 2.43E-05 0.0879 no up up no dn no 18:1/16:1-PE+blood d18:0-18:3-SM+blood 0 -0.553921569 -0.416068376 serum_phospholipids serum_phospholipids 0.000184 0.0879 up up no no dn no 18:1/18:1-PC+blood d18:0-18:3-SM+blood 0 -0.573529412 0 serum_phospholipids serum_phospholipids 1.34E-05 0.0879 no up up no dn no 18:1/20:4-PE+blood d18:0-18:3-SM+blood 0.648120301 0 0 serum_phospholipids serum_phospholipids 0.0578 0.0879 up no no no dn no 18:1/22:6-PE+blood d18:0-18:3-SM+blood 0.535338346 0 0 serum_phospholipids serum_phospholipids 0.0047 0.0879 no up no no dn no 18:3/18:2-PC+blood d18:0-18:3-SM+blood 0.506766917 0.786764706 0 serum_phospholipids serum_phospholipids 0.0394 0.0879 no no up no dn no 18:3n3+blood d18:0-18:3-SM+blood 0.448120301 0 0 serum_fattyacid serum_phospholipids 0.291 0.0879 no no no no dn no 20:0/20:5-PC+blood d18:0-18:3-SM+blood 0.490225564 0 0 serum_phospholipids serum_phospholipids 0.882 0.0879 no no no no dn no 20:1/20:4-PE+blood d18:0-18:3-SM+blood 0.70075188 0 0 serum_phospholipids serum_phospholipids 0.0042 0.0879 up up no no dn no 20:2/18:3-PE+blood d18:0-18:3-SM+blood 0.553383459 0 0 serum_phospholipids serum_phospholipids 0.0391 0.0879 up up no no dn no 20:3-LPE+blood d18:0-18:3-SM+blood 0 -0.56127451 0 serum_phospholipids serum_phospholipids 0.084 0.0879 no up no no dn no 20:3n6+blood d18:0-18:3-SM+blood 0 -0.49754902 0 serum_fattyacid serum_phospholipids 0.0884 0.0879 up no no no dn no 20:4/18:0-PE+blood d18:0-18:3-SM+blood 0.508270677 0 0 serum_phospholipids serum_phospholipids 0.000755 0.0879 up up no no dn no 20:4n6+blood d18:0-18:3-SM+blood 0.520300752 0 0 serum_fattyacid serum_phospholipids 0.133 0.0879 no no no no dn no 20:5/18:0-PC+blood d18:0-18:3-SM+blood 0 0 -0.439316239 serum_phospholipids serum_phospholipids 3.97E-06 0.0879 no up up no dn no d18:0-16:0-SM+blood d18:0-18:3-SM+blood 0.732330827 0 0.552136752 serum_phospholipids serum_phospholipids 0.202 0.0879 no no no no dn no 12-ketoDCA+blood d18:0-24:1-SM+blood 0 0.540081806 0 serum_bileacids serum_phospholipids 0.517 0.0609 no no no no dn dn "12,13-EPOME+blood" d18:0-24:1-SM+blood 0.465086256 0 0 serum_ARA serum_phospholipids 0.901 0.0609 no no no no dn dn 14:0/18:2-PC+blood d18:0-24:1-SM+blood 0 0 0.418803419 serum_phospholipids serum_phospholipids 0.102 0.0609 no up no no dn dn 14:0/20:4-PC+blood d18:0-24:1-SM+blood 0 0 0.402393162 serum_phospholipids serum_phospholipids 0.486 0.0609 no no no no dn dn 14:0+blood d18:0-24:1-SM+blood 0 -0.553921569 0 yes serum_fattyacid serum_phospholipids 0.00572 0.0609 up no dn no dn dn 14:1/18:2-PG+blood d18:0-24:1-SM+blood 0 0 0.444102564 serum_phospholipids serum_phospholipids 0.00259 0.0609 no up up no dn dn 16:0/18:2-PC+blood d18:0-24:1-SM+blood 0 0 -0.530940171 serum_phospholipids serum_phospholipids 3.24E-06 0.0609 no up up no dn dn 16:0/20:4-PC+blood d18:0-24:1-SM+blood 0 0 -0.554871795 serum_phospholipids serum_phospholipids 0.0262 0.0609 no up no no dn dn 16:1-LPC+blood d18:0-24:1-SM+blood 0 0 0.444102564 serum_phospholipids serum_phospholipids 0.0241 0.0609 no up no no dn dn 16:1/16:0-PC+blood d18:0-24:1-SM+blood 0 0 -0.574700855 serum_phospholipids serum_phospholipids 0.0215 0.0609 no up up no dn dn 16:1/16:1-PC+blood d18:0-24:1-SM+blood 0 0 -0.461880342 serum_phospholipids serum_phospholipids 0.0177 0.0609 no no up no dn dn 18:0/18:1-PI+blood d18:0-24:1-SM+blood 0 0 0.504273504 serum_phospholipids serum_phospholipids 0.599 0.0609 no no no no dn dn 18:0/18:2-PC+blood d18:0-24:1-SM+blood -0.454135338 0 -0.424957265 serum_phospholipids serum_phospholipids 1.74E-06 0.0609 no up up no dn dn 18:0/18:2-PI+blood d18:0-24:1-SM+blood 0 0 0.403076923 serum_phospholipids serum_phospholipids 0.179 0.0609 no no no no dn dn 18:0/20:2-PC+blood d18:0-24:1-SM+blood 0 0.764705882 0 serum_phospholipids serum_phospholipids 0.733 0.0609 no no no no dn dn 18:0/20:3-PC+blood d18:0-24:1-SM+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.0682 0.0609 no up no no dn dn 18:0/20:4-PC+blood d18:0-24:1-SM+blood 0 0 -0.427008547 serum_phospholipids serum_phospholipids 0.454 0.0609 no no no no dn dn 18:0/22:6-PC+blood d18:0-24:1-SM+blood -0.536842105 0 0 serum_phospholipids serum_phospholipids 0.0775 0.0609 no no up no dn dn 18:1/16:0-PC+blood d18:0-24:1-SM+blood 0 0 -0.530940171 serum_phospholipids serum_phospholipids 2.43E-05 0.0609 no up up no dn dn 18:1/16:0-PI+blood d18:0-24:1-SM+blood 0 0 0.461196581 serum_phospholipids serum_phospholipids 0.793 0.0609 no no no no dn dn 18:1/18:0-PC+blood d18:0-24:1-SM+blood -0.461654135 0 -0.47008547 serum_phospholipids serum_phospholipids 1.83E-06 0.0609 no up up no dn dn 18:1/18:0-PI+blood d18:0-24:1-SM+blood 0 0 0.460512821 serum_phospholipids serum_phospholipids 0.0931 0.0609 no no up no dn dn 18:1/22:6-PE+blood d18:0-24:1-SM+blood 0 0 -0.415384615 serum_phospholipids serum_phospholipids 0.0047 0.0609 no up no no dn dn 18:1+blood d18:0-24:1-SM+blood 0 -0.583333333 0 yes serum_fattyacid serum_phospholipids 0.00202 0.0609 up no dn no dn dn 18:2/16:0-PC+blood d18:0-24:1-SM+blood 0 0 -0.568547009 serum_phospholipids serum_phospholipids 8.67E-05 0.0609 no up up no dn dn 18:3n3+blood d18:0-24:1-SM+blood 0 -0.495098039 0 serum_fattyacid serum_phospholipids 0.291 0.0609 no no no no dn dn 20:0-LPC+blood d18:0-24:1-SM+blood 0 0.509803922 0 serum_phospholipids serum_phospholipids 0.199 0.0609 no no no no dn dn 20:1-LPA+blood d18:0-24:1-SM+blood -0.509774436 0 0 serum_phospholipids serum_phospholipids 0.0187 0.0609 dn dn no no dn dn 20:1-LPE+blood d18:0-24:1-SM+blood 0 0.50245098 0 serum_phospholipids serum_phospholipids 0.465 0.0609 no no no no dn dn 20:1/20:4-PC+blood d18:0-24:1-SM+blood -0.583458647 0 0 serum_phospholipids serum_phospholipids 0.0419 0.0609 no no up no dn dn 20:1/20:4-PE+blood d18:0-24:1-SM+blood 0.512781955 0 0 serum_phospholipids serum_phospholipids 0.0042 0.0609 up up no no dn dn 20:1+blood d18:0-24:1-SM+blood 0 0 0.461880342 yes serum_fattyacid serum_phospholipids 2.56E-05 0.0609 dn dn dn no dn dn 20:2/18:3-PE+blood d18:0-24:1-SM+blood 0.553383459 0 0 serum_phospholipids serum_phospholipids 0.0391 0.0609 up up no no dn dn 20:3-LPE+blood d18:0-24:1-SM+blood 0.44962406 0 0 serum_phospholipids serum_phospholipids 0.084 0.0609 no up no no dn dn 20:3/16:0-PC+blood d18:0-24:1-SM+blood 0 0 -0.534358974 serum_phospholipids serum_phospholipids 0.00405 0.0609 no up up no dn dn 20:4-LPC+blood d18:0-24:1-SM+blood 0.463157895 0 0 serum_phospholipids serum_phospholipids 0.949 0.0609 no no no no dn dn 20:4-LPE+blood d18:0-24:1-SM+blood 0.511278195 0 0 serum_phospholipids serum_phospholipids 0.552 0.0609 no no no no dn dn 20:4n6+blood d18:0-24:1-SM+blood 0.593984962 0 0 serum_fattyacid serum_phospholipids 0.133 0.0609 no no no no dn dn 20:5/18:0-PC+blood d18:0-24:1-SM+blood -0.547368421 0 0 serum_phospholipids serum_phospholipids 3.97E-06 0.0609 no up up no dn dn 22:2-LPA+blood d18:0-24:1-SM+blood -0.484210526 0 0 serum_phospholipids serum_phospholipids 0.0443 0.0609 dn no no no dn dn 24:1+blood d18:0-24:1-SM+blood 0 -0.575980392 0 serum_fattyacid serum_phospholipids 0.00582 0.0609 no dn dn no dn dn Asthma d18:0-24:1-SM+blood 0 0 0.462307692 kegg serum_phospholipids NA 0.0609 no no no no dn dn Blautia d18:0-24:1-SM+blood 0 0 0.405148182 acetate-producing Genus serum_phospholipids 1.36E-05 0.0609 up dn dn no dn dn Butyricimonas d18:0-24:1-SM+blood 0 0 -0.422082098 butyrate-producing Genus serum_phospholipids 0.17 0.0609 no no no no dn dn Clostridium d18:0-24:1-SM+blood -0.679202756 0 0 Genus serum_phospholipids 0.925 0.0609 no no no no dn dn d18:0-16:0-SM+blood d18:0-24:1-SM+blood 0.747368421 0 0.552136752 serum_phospholipids serum_phospholipids 0.202 0.0609 no no no no dn dn GABAergic synapse d18:0-24:1-SM+blood 0 0 -0.423846154 kegg serum_phospholipids NA 0.0609 no up up no dn dn Inflammatory bowel disease d18:0-24:1-SM+blood 0 0 0.539230769 kegg serum_phospholipids NA 0.0609 no no no no dn dn Intestinal immune network for IgA production d18:0-24:1-SM+blood 0 0 0.414615385 kegg serum_phospholipids NA 0.0609 no no no no dn dn Lachnospira d18:0-24:1-SM+blood 0 0 -0.403767715 butyrate-producing Genus serum_phospholipids 0.279 0.0609 no no no no dn dn Legionellosis d18:0-24:1-SM+blood 0 0.517647059 0 kegg serum_phospholipids NA 0.0609 no no no no dn dn Mineral absorption d18:0-24:1-SM+blood 0 0 -0.41 kegg serum_phospholipids NA 0.0609 no no no no dn dn Necroptosis d18:0-24:1-SM+blood 0 0 -0.457692308 kegg serum_phospholipids NA 0.0609 no no no no dn dn Odoribacter d18:0-24:1-SM+blood 0 0 -0.42327702 butyrate-producing Genus serum_phospholipids 0.798 0.0609 no no no no dn dn Th1 and Th2 cell differentiation d18:0-24:1-SM+blood 0 0 0.521538462 kegg serum_phospholipids NA 0.0609 no no no no dn dn Th17 cell differentiation d18:0-24:1-SM+blood 0 0 0.543846154 kegg serum_phospholipids NA 0.0609 no no no no dn dn Thyroid hormone signaling pathway d18:0-24:1-SM+blood 0 0 0.405384615 kegg serum_phospholipids NA 0.0609 no no no no dn dn 13-HODE+blood d18:1-14:0-SM+blood 0 -0.642156863 0 serum_ARA serum_phospholipids 0.32 0.94 no no no no no no 14:0-LPC+blood d18:1-14:0-SM+blood 0 0 0.476923077 serum_phospholipids serum_phospholipids 0.00689 0.94 up up no no no no 14:0/18:2-PC+blood d18:1-14:0-SM+blood 0 0 0.676581197 serum_phospholipids serum_phospholipids 0.102 0.94 no up no no no no 14:0/20:4-PC+blood d18:1-14:0-SM+blood 0.618045113 0.531862745 0.703247863 serum_phospholipids serum_phospholipids 0.486 0.94 no no no no no no 14:1/18:2-PG+blood d18:1-14:0-SM+blood 0 0 0.576752137 serum_phospholipids serum_phospholipids 0.00259 0.94 no up up no no no 16:0-LPC+blood d18:1-14:0-SM+blood 0 0 0.414700855 serum_phospholipids serum_phospholipids 0.00456 0.94 up up no no no no 16:0/14:0-PC+blood d18:1-14:0-SM+blood 0 0 -0.604786325 serum_phospholipids serum_phospholipids 0.0206 0.94 no up up no no no 16:0/16:0-PI+blood d18:1-14:0-SM+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.358 0.94 no no no no no no 16:0/18:0-PS+blood d18:1-14:0-SM+blood 0.511278195 0 0.401709402 serum_phospholipids serum_phospholipids 0.377 0.94 no no no no no no 16:0/18:1-PC+blood d18:1-14:0-SM+blood 0 0 -0.487179487 serum_phospholipids serum_phospholipids 6.15E-07 0.94 up up up no no no 16:0/18:2-PC+blood d18:1-14:0-SM+blood 0 -0.539215686 -0.844786325 serum_phospholipids serum_phospholipids 3.24E-06 0.94 no up up no no no 16:0/20:4-PC+blood d18:1-14:0-SM+blood 0 0 -0.617777778 serum_phospholipids serum_phospholipids 0.0262 0.94 no up no no no no 16:0/20:4-PI+blood d18:1-14:0-SM+blood 0.508270677 0 0 serum_phospholipids serum_phospholipids 0.558 0.94 no no no no no no 16:0/20:5-PC+blood d18:1-14:0-SM+blood 0 0.56127451 0 serum_phospholipids serum_phospholipids 0.628 0.94 no no no no no no 16:0/22:6-PC+blood d18:1-14:0-SM+blood 0 0 -0.463247863 serum_phospholipids serum_phospholipids 4.53E-05 0.94 no up up no no no 16:0/22:6-PE+blood d18:1-14:0-SM+blood 0.461654135 0 0 serum_phospholipids serum_phospholipids 0.000934 0.94 up up no no no no 16:1/16:0-PC+blood d18:1-14:0-SM+blood 0 0 -0.67042735 serum_phospholipids serum_phospholipids 0.0215 0.94 no up up no no no 18:0/16:0-PC+blood d18:1-14:0-SM+blood 0 0 -0.506324786 serum_phospholipids serum_phospholipids 9.64E-07 0.94 up up up no no no 18:0/18:0-PE+blood d18:1-14:0-SM+blood 0 0 0.40991453 serum_phospholipids serum_phospholipids 0.00896 0.94 up up no no no no 18:0/18:0-PS+blood d18:1-14:0-SM+blood 0.559398496 0.487745098 0 serum_phospholipids serum_phospholipids 0.00617 0.94 no up no no no no 18:0/18:2-PC+blood d18:1-14:0-SM+blood -0.446616541 0 -0.622564103 serum_phospholipids serum_phospholipids 1.74E-06 0.94 no up up no no no 18:0/20:4-PC+blood d18:1-14:0-SM+blood 0 0 -0.476239316 serum_phospholipids serum_phospholipids 0.454 0.94 no no no no no no 18:0/20:5-PC+blood d18:1-14:0-SM+blood 0 0 -0.465299145 serum_phospholipids serum_phospholipids 0.17 0.94 no no no no no no 18:0/22:6-PE+blood d18:1-14:0-SM+blood 0.49924812 0 0 serum_phospholipids serum_phospholipids 0.00022 0.94 up up no no no no 18:1/16:0-PC+blood d18:1-14:0-SM+blood 0 -0.553921569 -0.857094017 serum_phospholipids serum_phospholipids 2.43E-05 0.94 no up up no no no 18:1/18:0-PC+blood d18:1-14:0-SM+blood 0 0 -0.647863248 serum_phospholipids serum_phospholipids 1.83E-06 0.94 no up up no no no 18:1/20:4-PC+blood d18:1-14:0-SM+blood 0 0 -0.426324786 serum_phospholipids serum_phospholipids 0.582 0.94 no no no no no no 18:2-LPC+blood d18:1-14:0-SM+blood -0.454135338 0 0 serum_phospholipids serum_phospholipids 0.00743 0.94 dn no up no no no 18:2/16:0-PC+blood d18:1-14:0-SM+blood 0 -0.490196078 -0.483076923 serum_phospholipids serum_phospholipids 8.67E-05 0.94 no up up no no no 18:3/16:0-PE+blood d18:1-14:0-SM+blood 0.454135338 0 0 serum_phospholipids serum_phospholipids 0.00149 0.94 up up no no no no 18:3/18:2-PC+blood d18:1-14:0-SM+blood 0.469172932 0 0 serum_phospholipids serum_phospholipids 0.0394 0.94 no no up no no no 20:0/20:5-PC+blood d18:1-14:0-SM+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 0.882 0.94 no no no no no no 20:1/20:4-PC+blood d18:1-14:0-SM+blood 0 0 -0.415384615 serum_phospholipids serum_phospholipids 0.0419 0.94 no no up no no no 20:2/18:1-PE+blood d18:1-14:0-SM+blood 0.458646617 0 0 serum_phospholipids serum_phospholipids 0.00208 0.94 up up no no no no 20:2+blood d18:1-14:0-SM+blood 0 -0.544117647 0 serum_fattyacid serum_phospholipids 0.478 0.94 no no no no no no 20:3/16:0-PC+blood d18:1-14:0-SM+blood 0 0 -0.661538462 serum_phospholipids serum_phospholipids 0.00405 0.94 no up up no no no 20:5/18:0-PC+blood d18:1-14:0-SM+blood 0 0 -0.491282051 serum_phospholipids serum_phospholipids 3.97E-06 0.94 no up up no no no 3-(3-Hydroxyphenyl)propanoic acid+stool d18:1-14:0-SM+blood 0 0 0.47518797 stool_cometabolism serum_phospholipids 0.33 0.94 no no no no no no 8-HETE+blood d18:1-14:0-SM+blood 0 -0.512254902 0 serum_ARA serum_phospholipids 0.741 0.94 no no no no no no ACA+blood d18:1-14:0-SM+blood -0.571993654 0 0 serum_bileacids serum_phospholipids 0.338 0.94 no no no no no no Adipocytokine signaling pathway d18:1-14:0-SM+blood -0.470175439 0 0 kegg serum_phospholipids NA 0.94 no no no no no no Alcoholism d18:1-14:0-SM+blood 0 -0.558823529 0 kegg serum_phospholipids NA 0.94 no no no no no no Amoebiasis d18:1-14:0-SM+blood -0.503508772 -0.552941176 0 kegg serum_phospholipids NA 0.94 no no no no no no AMPK signaling pathway d18:1-14:0-SM+blood -0.459649123 0 0 kegg serum_phospholipids NA 0.94 no no no no no no Amyotrophic lateral sclerosis d18:1-14:0-SM+blood 0 0 0.452307692 kegg serum_phospholipids NA 0.94 no no no no no no Apelin signaling pathway d18:1-14:0-SM+blood 0 0.552941176 0 kegg serum_phospholipids NA 0.94 no no no no no no Asthma d18:1-14:0-SM+blood -0.624561404 0 0 kegg serum_phospholipids NA 0.94 no no no no no no B cell receptor signaling pathway d18:1-14:0-SM+blood 0 -0.505882353 0 kegg serum_phospholipids NA 0.94 no no no no no no Bifidobacterium d18:1-14:0-SM+blood 0.600225691 0 0 acetate-producing Genus serum_phospholipids 0.105 0.94 no dn no no no no Bladder cancer d18:1-14:0-SM+blood 0 -0.561764706 0 kegg serum_phospholipids NA 0.94 no no no no no no Butyricimonas d18:1-14:0-SM+blood 0 0 -0.400436862 butyrate-producing Genus serum_phospholipids 0.17 0.94 no no no no no no C-type lectin receptor signaling pathway d18:1-14:0-SM+blood 0 -0.514705882 0 kegg serum_phospholipids NA 0.94 no no no no no no cAMP signaling pathway d18:1-14:0-SM+blood 0 -0.579411765 0 yes kegg serum_phospholipids NA 0.94 no up up no no no Cardiac muscle contraction d18:1-14:0-SM+blood 0 0 0.408461538 kegg serum_phospholipids NA 0.94 no no up no no no Cell cycle d18:1-14:0-SM+blood 0.475438596 0.585294118 0 kegg serum_phospholipids NA 0.94 no no no no no no Central carbon metabolism in cancer d18:1-14:0-SM+blood 0 0.65 0 kegg serum_phospholipids NA 0.94 no no no no no no Chagas disease d18:1-14:0-SM+blood 0 -0.517647059 0 kegg serum_phospholipids NA 0.94 no no no no no no Chemokine signaling pathway d18:1-14:0-SM+blood 0 -0.517647059 0 kegg serum_phospholipids NA 0.94 no no no no no no Clostridium d18:1-14:0-SM+blood 0.461075625 0 0 Genus serum_phospholipids 0.925 0.94 no no no no no no Colorectal cancer d18:1-14:0-SM+blood 0 0.555882353 0 kegg serum_phospholipids NA 0.94 no no no no no no Cysteine+blood d18:1-14:0-SM+blood 0 0 -0.406495726 yes serum_aminoacids serum_phospholipids 1.81E-07 0.94 dn up up no no no Cystine+blood d18:1-14:0-SM+blood -0.506766917 -0.524509804 0 yes serum_aminoacids serum_phospholipids 0.00028 0.94 up up no no no no d18:0-16:0-SM+blood d18:1-14:0-SM+blood 0 0 0.551452991 serum_phospholipids serum_phospholipids 0.202 0.94 no no no no no no d18:0-18:3-SM+blood d18:1-14:0-SM+blood 0.505263158 0.482843137 0.641025641 serum_phospholipids serum_phospholipids 0.0879 0.94 no dn no no no no d18:0-24:1-SM+blood d18:1-14:0-SM+blood 0 0.495098039 0.653333333 serum_phospholipids serum_phospholipids 0.0609 0.94 no dn dn no no no EGFR tyrosine kinase inhibitor resistance d18:1-14:0-SM+blood 0 0.597058824 0 kegg serum_phospholipids NA 0.94 no no no no no no Epithelial cell signaling in Helicobacter pylori infection d18:1-14:0-SM+blood 0 -0.55 0 kegg serum_phospholipids NA 0.94 no no no no no no Faecalibacterium d18:1-14:0-SM+blood 0 -0.512254902 0 butyrate-producing Genus serum_phospholipids 0.0039 0.94 no dn dn no no no Ferroptosis d18:1-14:0-SM+blood -0.464912281 -0.529411765 0 kegg serum_phospholipids NA 0.94 no no no no no no Gap junction d18:1-14:0-SM+blood 0 0 0.422307692 kegg serum_phospholipids NA 0.94 no no no no no no Glutamatergic synapse d18:1-14:0-SM+blood -0.642105263 0 0 kegg serum_phospholipids NA 0.94 no up up no no no Glycolysis / Gluconeogenesis d18:1-14:0-SM+blood 0 0.535294118 0 kegg serum_phospholipids NA 0.94 no no no no no no Hematopoietic cell lineage d18:1-14:0-SM+blood -0.466666667 0.505882353 0 kegg serum_phospholipids NA 0.94 no no no no no no HIF-1 signaling pathway d18:1-14:0-SM+blood 0 0.594117647 0 kegg serum_phospholipids NA 0.94 no no no no no no Huntington disease d18:1-14:0-SM+blood 0 0 0.406923077 kegg serum_phospholipids NA 0.94 no no no no no no IL-17 signaling pathway d18:1-14:0-SM+blood 0 0 -0.453846154 kegg serum_phospholipids NA 0.94 no no no no no no Inflammatory bowel disease d18:1-14:0-SM+blood -0.494736842 0 0 kegg serum_phospholipids NA 0.94 no no no no no no Insulin signaling pathway d18:1-14:0-SM+blood 0 0.576470588 0 kegg serum_phospholipids NA 0.94 no no no no no no Intestinal immune network for IgA production d18:1-14:0-SM+blood -0.649122807 0 0 kegg serum_phospholipids NA 0.94 no no no no no no Lachnospira d18:1-14:0-SM+blood 0 0 -0.482192488 butyrate-producing Genus serum_phospholipids 0.279 0.94 no no no no no no Legionellosis d18:1-14:0-SM+blood 0.596491228 0.544117647 0 kegg serum_phospholipids NA 0.94 no no no no no no Leishmaniasis d18:1-14:0-SM+blood 0.575438596 0.552941176 0 kegg serum_phospholipids NA 0.94 no no no no no no Lipid and atherosclerosis d18:1-14:0-SM+blood 0 -0.502941176 0 kegg serum_phospholipids NA 0.94 no no no no no no Long-term depression d18:1-14:0-SM+blood -0.543859649 0 0 kegg serum_phospholipids NA 0.94 no no no no no no Longevity regulating pathway d18:1-14:0-SM+blood -0.510526316 0 0 kegg serum_phospholipids NA 0.94 no no no no no no Measles d18:1-14:0-SM+blood 0.50877193 0 0 kegg serum_phospholipids NA 0.94 no no no no no no Methanobrevibacter d18:1-14:0-SM+blood 0 0.525105032 0 Genus serum_phospholipids 0.629 0.94 no no no no no no Morphine addiction d18:1-14:0-SM+blood -0.480701754 0 0 kegg serum_phospholipids NA 0.94 no up up no no no mTOR signaling pathway d18:1-14:0-SM+blood 0 0.573529412 0 kegg serum_phospholipids NA 0.94 no no no no no no Non-alcoholic fatty liver disease d18:1-14:0-SM+blood 0 0 0.581538462 kegg serum_phospholipids NA 0.94 no no no no no no nutriCA+stool d18:1-14:0-SM+blood 0 0.614704769 0 stool_bileacids serum_phospholipids 0.481 0.94 no no no no no no Oocyte meiosis d18:1-14:0-SM+blood 0 0.573529412 0 kegg serum_phospholipids NA 0.94 no no no no no no Parabacteroides d18:1-14:0-SM+blood 0 0.536764706 0 Genus serum_phospholipids 4.19E-05 0.94 no up up no no no Phospholipase D signaling pathway d18:1-14:0-SM+blood 0 -0.526470588 0 kegg serum_phospholipids NA 0.94 no up up no no no PI3K-Akt signaling pathway d18:1-14:0-SM+blood 0.549122807 0 0 yes kegg serum_phospholipids NA 0.94 no up up no no no Proteasome d18:1-14:0-SM+blood 0 0 -0.404615385 kegg serum_phospholipids NA 0.94 no no no no no no Protein processing in endoplasmic reticulum d18:1-14:0-SM+blood 0 0.529411765 0 kegg serum_phospholipids NA 0.94 no no no no no no Proteoglycans in cancer d18:1-14:0-SM+blood 0 0.655882353 0 kegg serum_phospholipids NA 0.94 no no no no no no Ras signaling pathway d18:1-14:0-SM+blood 0 0.514705882 0 yes kegg serum_phospholipids NA 0.94 no up up no no no Relaxin signaling pathway d18:1-14:0-SM+blood 0 -0.508823529 0 kegg serum_phospholipids NA 0.94 no no no no no no Ribosome biogenesis in eukaryotes d18:1-14:0-SM+blood 0 0.508823529 0 kegg serum_phospholipids NA 0.94 no no no no no no RNA degradation d18:1-14:0-SM+blood 0 0.544117647 0 kegg serum_phospholipids NA 0.94 no no no no no no RNA transport d18:1-14:0-SM+blood 0.564912281 0.682352941 0 kegg serum_phospholipids NA 0.94 no no no no no no Ruminococcus d18:1-14:0-SM+blood 0 0 0.505296713 Genus serum_phospholipids 0.0679 0.94 no no dn no no no Salivary secretion d18:1-14:0-SM+blood -0.531578947 0 0 kegg serum_phospholipids NA 0.94 no no no no no no Spinocerebellar ataxia d18:1-14:0-SM+blood 0 0.647058824 0 kegg serum_phospholipids NA 0.94 no no no no no no T cell receptor signaling pathway d18:1-14:0-SM+blood 0.484210526 0 0 kegg serum_phospholipids NA 0.94 no no no no no no Toll-like receptor signaling pathway d18:1-14:0-SM+blood 0 -0.552941176 0 yes kegg serum_phospholipids NA 0.94 no no no no no no Transcriptional misregulation in cancer d18:1-14:0-SM+blood 0 -0.529411765 0 kegg serum_phospholipids NA 0.94 no no no no no no TUDCA+stool d18:1-14:0-SM+blood 0 -0.705458603 0 stool_bileacids serum_phospholipids 0.241 0.94 no no no no no no Viral protein interaction with cytokine and cytokine receptor d18:1-14:0-SM+blood 0 -0.514705882 0 kegg serum_phospholipids NA 0.94 no no no no no no Wnt signaling pathway d18:1-14:0-SM+blood 0 0.629411765 0 kegg serum_phospholipids NA 0.94 no no no no no no 13-HODE+blood d18:1-14:1-SM+blood 0 -0.546568627 0 serum_ARA serum_phospholipids 0.32 0.0952 no no no no dn no 14:0-LPC+blood d18:1-14:1-SM+blood 0 0 0.427692308 serum_phospholipids serum_phospholipids 0.00689 0.0952 up up no no dn no 14:0/16:0-PC+blood d18:1-14:1-SM+blood 0.497744361 0 0 serum_phospholipids serum_phospholipids 0.0358 0.0952 no up no no dn no 14:0/18:2-PC+blood d18:1-14:1-SM+blood 0 0 0.649230769 serum_phospholipids serum_phospholipids 0.102 0.0952 no up no no dn no 14:0/20:4-PC+blood d18:1-14:1-SM+blood 0.65112782 0 0.737435897 serum_phospholipids serum_phospholipids 0.486 0.0952 no no no no dn no 14:1/18:2-PG+blood d18:1-14:1-SM+blood 0 0 0.537777778 serum_phospholipids serum_phospholipids 0.00259 0.0952 no up up no dn no 16:0/14:0-PC+blood d18:1-14:1-SM+blood 0 0 -0.447521368 serum_phospholipids serum_phospholipids 0.0206 0.0952 no up up no dn no 16:0/18:0-PS+blood d18:1-14:1-SM+blood 0.589473684 0 0 serum_phospholipids serum_phospholipids 0.377 0.0952 no no no no dn no 16:0/18:2-PC+blood d18:1-14:1-SM+blood 0 -0.602941176 -0.718290598 serum_phospholipids serum_phospholipids 3.24E-06 0.0952 no up up no dn no 16:0/18:3-PC+blood d18:1-14:1-SM+blood 0 0 0.473504274 serum_phospholipids serum_phospholipids 0.00216 0.0952 no up up no dn no 16:0/20:4-PC+blood d18:1-14:1-SM+blood 0 0 -0.416752137 serum_phospholipids serum_phospholipids 0.0262 0.0952 no up no no dn no 16:0/20:4-PI+blood d18:1-14:1-SM+blood 0.469172932 0.585784314 0 serum_phospholipids serum_phospholipids 0.558 0.0952 no no no no dn no 16:0/22:6-PC+blood d18:1-14:1-SM+blood 0 0 -0.537094017 serum_phospholipids serum_phospholipids 4.53E-05 0.0952 no up up no dn no 16:1/16:0-PC+blood d18:1-14:1-SM+blood 0 0 -0.568547009 serum_phospholipids serum_phospholipids 0.0215 0.0952 no up up no dn no 18:0-LPC+blood d18:1-14:1-SM+blood 0 0.610294118 0 serum_phospholipids serum_phospholipids 0.554 0.0952 no no no no dn no 18:0/18:0-PS+blood d18:1-14:1-SM+blood 0.593984962 0 0 serum_phospholipids serum_phospholipids 0.00617 0.0952 no up no no dn no 18:0/18:1-PC+blood d18:1-14:1-SM+blood 0 0.50245098 0 serum_phospholipids serum_phospholipids 0.393 0.0952 no no no no dn no 18:0/18:2-PC+blood d18:1-14:1-SM+blood 0 0 -0.567179487 serum_phospholipids serum_phospholipids 1.74E-06 0.0952 no up up no dn no 18:0/20:2-PC+blood d18:1-14:1-SM+blood 0 0.568627451 0 serum_phospholipids serum_phospholipids 0.733 0.0952 no no no no dn no 18:0/20:3-PC+blood d18:1-14:1-SM+blood 0 0.566176471 0 serum_phospholipids serum_phospholipids 0.0682 0.0952 no up no no dn no 18:0/22:6-PC+blood d18:1-14:1-SM+blood 0 0 -0.407863248 serum_phospholipids serum_phospholipids 0.0775 0.0952 no no up no dn no 18:1/16:0-PC+blood d18:1-14:1-SM+blood 0 -0.593137255 -0.726495726 serum_phospholipids serum_phospholipids 2.43E-05 0.0952 no up up no dn no 18:1/18:0-PC+blood d18:1-14:1-SM+blood 0 0 -0.573333333 serum_phospholipids serum_phospholipids 1.83E-06 0.0952 no up up no dn no 18:1/22:6-PE+blood d18:1-14:1-SM+blood 0 0 -0.404444444 serum_phospholipids serum_phospholipids 0.0047 0.0952 no up no no dn no 18:2-LPA+blood d18:1-14:1-SM+blood 0 -0.541666667 0 serum_phospholipids serum_phospholipids 0.00684 0.0952 dn no up no dn no 18:2-LPC+blood d18:1-14:1-SM+blood -0.535338346 -0.546568627 0 serum_phospholipids serum_phospholipids 0.00743 0.0952 dn no up no dn no 18:2/16:0-PC+blood d18:1-14:1-SM+blood 0 -0.541666667 -0.476923077 serum_phospholipids serum_phospholipids 8.67E-05 0.0952 no up up no dn no 18:2n6c+blood d18:1-14:1-SM+blood 0 -0.495098039 0 serum_fattyacid serum_phospholipids 0.15 0.0952 no no no no dn no 18:3/16:0-PE+blood d18:1-14:1-SM+blood 0.470676692 0 0 serum_phospholipids serum_phospholipids 0.00149 0.0952 up up no no dn no 18:3/18:2-PC+blood d18:1-14:1-SM+blood 0.452631579 0 0 serum_phospholipids serum_phospholipids 0.0394 0.0952 no no up no dn no 18:3n3+blood d18:1-14:1-SM+blood 0 -0.485294118 0 serum_fattyacid serum_phospholipids 0.291 0.0952 no no no no dn no 18:3n6+blood d18:1-14:1-SM+blood 0.454135338 0 0.635555556 serum_fattyacid serum_phospholipids 0.0463 0.0952 up no dn no dn no 20:0-LPC+blood d18:1-14:1-SM+blood 0 0.482843137 0 serum_phospholipids serum_phospholipids 0.199 0.0952 no no no no dn no 20:0/20:4-PE+blood d18:1-14:1-SM+blood 0 0.522058824 0 serum_phospholipids serum_phospholipids 0.00128 0.0952 up up no no dn no 20:0/20:5-PC+blood d18:1-14:1-SM+blood 0 0.56127451 0 serum_phospholipids serum_phospholipids 0.882 0.0952 no no no no dn no 20:1/20:4-PC+blood d18:1-14:1-SM+blood 0 0 -0.401025641 serum_phospholipids serum_phospholipids 0.0419 0.0952 no no up no dn no 20:1/20:4-PE+blood d18:1-14:1-SM+blood 0 0.509803922 0 serum_phospholipids serum_phospholipids 0.0042 0.0952 up up no no dn no 20:2/18:0-PC+blood d18:1-14:1-SM+blood 0 0.575980392 0 serum_phospholipids serum_phospholipids 0.0427 0.0952 no up no no dn no 20:3/16:0-PC+blood d18:1-14:1-SM+blood 0 0 -0.478974359 serum_phospholipids serum_phospholipids 0.00405 0.0952 no up up no dn no 20:5/18:0-PC+blood d18:1-14:1-SM+blood 0 0 -0.525470085 serum_phospholipids serum_phospholipids 3.97E-06 0.0952 no up up no dn no 24:1+blood d18:1-14:1-SM+blood 0 -0.485294118 0 serum_fattyacid serum_phospholipids 0.00582 0.0952 no dn dn no dn no 8-HETE+blood d18:1-14:1-SM+blood 0 -0.551470588 0 serum_ARA serum_phospholipids 0.741 0.0952 no no no no dn no 9-HODE+blood d18:1-14:1-SM+blood 0 -0.546568627 0 serum_ARA serum_phospholipids 0.297 0.0952 no no no no dn no AA+blood d18:1-14:1-SM+blood 0 -0.5 0 serum_ARA serum_phospholipids 0.212 0.0952 no no no no dn no acetic acid C2+blood d18:1-14:1-SM+blood 0 0 -0.448205128 serum_scfa serum_phospholipids 0.000193 0.0952 up dn no no dn no Betaine+blood d18:1-14:1-SM+blood 0 -0.544117647 0 serum_choline serum_phospholipids 0.857 0.0952 no no no no dn no CDCA+blood d18:1-14:1-SM+blood 0 0 0.447521368 serum_bileacids serum_phospholipids 0.506 0.0952 no no no no dn no Choline+blood d18:1-14:1-SM+blood 0 -0.490196078 0 serum_choline serum_phospholipids 0.0395 0.0952 no up no no dn no Creatinine+blood d18:1-14:1-SM+blood -0.544360902 -0.558823529 0 serum_choline serum_phospholipids 0.437 0.0952 no no no no dn no Cystine+blood d18:1-14:1-SM+blood -0.584962406 0 0 yes serum_aminoacids serum_phospholipids 0.00028 0.0952 up up no no dn no d18:0-16:0-SM+blood d18:1-14:1-SM+blood 0 0 0.512478632 serum_phospholipids serum_phospholipids 0.202 0.0952 no no no no dn no d18:0-18:3-SM+blood d18:1-14:1-SM+blood 0.580451128 0 0.753162393 serum_phospholipids serum_phospholipids 0.0879 0.0952 no dn no no dn no d18:0-24:1-SM+blood d18:1-14:1-SM+blood 0 0.583333333 0.463931624 serum_phospholipids serum_phospholipids 0.0609 0.0952 no dn dn no dn no d18:1-14:0-SM+blood d18:1-14:1-SM+blood 0.828571429 0.708333333 0.835213675 serum_phospholipids serum_phospholipids 0.94 0.0952 no no no no dn no 12-HEPE+blood d18:1-16:0-SM+blood 0 0 -0.434730621 serum_ARA serum_phospholipids 0.312 0.14 no no no no no no "12,13-EPOME+blood" d18:1-16:0-SM+blood 0 -0.707746697 0 serum_ARA serum_phospholipids 0.901 0.14 no no no no no no 16:0-LPC+blood d18:1-16:0-SM+blood 0 0.546568627 0 serum_phospholipids serum_phospholipids 0.00456 0.14 up up no no no no 16:0/18:2-PC+blood d18:1-16:0-SM+blood 0 0 -0.597948718 serum_phospholipids serum_phospholipids 3.24E-06 0.14 no up up no no no 16:0/20:3-PC+blood d18:1-16:0-SM+blood 0 -0.49754902 0 serum_phospholipids serum_phospholipids 5.43E-06 0.14 no up up no no no 16:0/20:5-PG+blood d18:1-16:0-SM+blood 0.571428571 0 0.592478632 serum_phospholipids serum_phospholipids 0.00656 0.14 no up no no no no 16:0/22:6-PC+blood d18:1-16:0-SM+blood 0 0 -0.574017094 serum_phospholipids serum_phospholipids 4.53E-05 0.14 no up up no no no 16:1/16:0-PC+blood d18:1-16:0-SM+blood 0 0 -0.610940171 serum_phospholipids serum_phospholipids 0.0215 0.14 no up up no no no 16:1/16:1-PC+blood d18:1-16:0-SM+blood 0 0 -0.451623932 serum_phospholipids serum_phospholipids 0.0177 0.14 no no up no no no 16:1/18:1-PG+blood d18:1-16:0-SM+blood 0 0 0.521367521 serum_phospholipids serum_phospholipids 3.21E-05 0.14 no up up no no no 16:1/18:2-PG+blood d18:1-16:0-SM+blood 0 0 0.465982906 serum_phospholipids serum_phospholipids 1.40E-08 0.14 no up up no no no 18:0/18:1-PI+blood d18:1-16:0-SM+blood 0 0 0.543247863 serum_phospholipids serum_phospholipids 0.599 0.14 no no no no no no 18:0/18:2-PC+blood d18:1-16:0-SM+blood 0 -0.546568627 -0.442735043 serum_phospholipids serum_phospholipids 1.74E-06 0.14 no up up no no no 18:0/18:2-PI+blood d18:1-16:0-SM+blood 0 0 0.513162393 serum_phospholipids serum_phospholipids 0.179 0.14 no no no no no no 18:0/22:6-PC+blood d18:1-16:0-SM+blood -0.485714286 0 -0.536410256 serum_phospholipids serum_phospholipids 0.0775 0.14 no no up no no no 18:1/16:0-PC+blood d18:1-16:0-SM+blood 0 0 -0.600683761 serum_phospholipids serum_phospholipids 2.43E-05 0.14 no up up no no no 18:1/18:0-PC+blood d18:1-16:0-SM+blood 0 -0.524509804 -0.472136752 serum_phospholipids serum_phospholipids 1.83E-06 0.14 no up up no no no 18:1/18:0-PI+blood d18:1-16:0-SM+blood 0 0 0.448205128 serum_phospholipids serum_phospholipids 0.0931 0.14 no no up no no no 18:1/18:1-PC+blood d18:1-16:0-SM+blood 0 -0.50245098 0 serum_phospholipids serum_phospholipids 1.34E-05 0.14 no up up no no no 18:1/18:1-PG+blood d18:1-16:0-SM+blood 0 0 0.584273504 serum_phospholipids serum_phospholipids 0.00352 0.14 no up up no no no 18:1/18:1-PI+blood d18:1-16:0-SM+blood 0 0 0.406495726 serum_phospholipids serum_phospholipids 0.111 0.14 dn no no no no no 18:1/18:2-PG+blood d18:1-16:0-SM+blood 0 0 0.507692308 serum_phospholipids serum_phospholipids 5.58E-07 0.14 no up up no no no 18:1/20:4-PE+blood d18:1-16:0-SM+blood 0.551879699 0 0 serum_phospholipids serum_phospholipids 0.0578 0.14 up no no no no no 18:1/22:6-PE+blood d18:1-16:0-SM+blood 0.469172932 0 -0.406495726 serum_phospholipids serum_phospholipids 0.0047 0.14 no up no no no no 18:2/18:2-PS+blood d18:1-16:0-SM+blood 0 0 0.496752137 serum_phospholipids serum_phospholipids 0.00674 0.14 up up no no no no 18:3n6+blood d18:1-16:0-SM+blood 0 0 0.421538462 serum_fattyacid serum_phospholipids 0.0463 0.14 up no dn no no no 20:0/20:4-PE+blood d18:1-16:0-SM+blood 0.545864662 0 0 serum_phospholipids serum_phospholipids 0.00128 0.14 up up no no no no 20:1/20:4-PC+blood d18:1-16:0-SM+blood -0.512781955 0 -0.489230769 serum_phospholipids serum_phospholipids 0.0419 0.14 no no up no no no 20:1/20:4-PE+blood d18:1-16:0-SM+blood 0.751879699 0 0 serum_phospholipids serum_phospholipids 0.0042 0.14 up up no no no no 20:2/18:3-PE+blood d18:1-16:0-SM+blood 0.670676692 0 0 serum_phospholipids serum_phospholipids 0.0391 0.14 up up no no no no 20:4-LPC+blood d18:1-16:0-SM+blood 0 0.566176471 0.496068376 serum_phospholipids serum_phospholipids 0.949 0.14 no no no no no no 20:4-LPE+blood d18:1-16:0-SM+blood 0.508270677 0 0 serum_phospholipids serum_phospholipids 0.552 0.14 no no no no no no 20:4/18:0-PE+blood d18:1-16:0-SM+blood 0.481203008 0 0 serum_phospholipids serum_phospholipids 0.000755 0.14 up up no no no no 20:4n6+blood d18:1-16:0-SM+blood 0.545864662 0 0 serum_fattyacid serum_phospholipids 0.133 0.14 no no no no no no 20:5/18:0-PC+blood d18:1-16:0-SM+blood 0 0 -0.606837607 serum_phospholipids serum_phospholipids 3.97E-06 0.14 no up up no no no 8-HETE+blood d18:1-16:0-SM+blood 0.509774436 0 0 serum_ARA serum_phospholipids 0.741 0.14 no no no no no no Aldosterone synthesis and secretion d18:1-16:0-SM+blood 0 0 0.413846154 kegg serum_phospholipids NA 0.14 no up up no no no Amphetamine addiction d18:1-16:0-SM+blood 0 0 0.417692308 kegg serum_phospholipids NA 0.14 no no no no no no Antigen processing and presentation d18:1-16:0-SM+blood 0 -0.647058824 0 kegg serum_phospholipids NA 0.14 no no no no no no Calcium signaling pathway d18:1-16:0-SM+blood 0 0 0.436153846 kegg serum_phospholipids NA 0.14 no up up no no no Chemical carcinogenesis - receptor activation d18:1-16:0-SM+blood 0 0.517647059 0 kegg serum_phospholipids NA 0.14 no no no no no no Choline metabolism in cancer d18:1-16:0-SM+blood 0 0.517647059 0 kegg serum_phospholipids NA 0.14 no no no no no no Clostridium d18:1-16:0-SM+blood -0.464836438 0 0 Genus serum_phospholipids 0.925 0.14 no no no no no no Cocaine addiction d18:1-16:0-SM+blood 0 0 0.437692308 kegg serum_phospholipids NA 0.14 no no no no no no d18:0-16:0-SM+blood d18:1-16:0-SM+blood 0.993984962 0.987745098 0.984957265 serum_phospholipids serum_phospholipids 0.202 0.14 no no no no no no d18:0-18:3-SM+blood d18:1-16:0-SM+blood 0.733834586 0 0.535042735 serum_phospholipids serum_phospholipids 0.0879 0.14 no dn no no no no d18:0-24:1-SM+blood d18:1-16:0-SM+blood 0.753383459 0 0.528888889 serum_phospholipids serum_phospholipids 0.0609 0.14 no dn dn no no no d18:1-14:0-SM+blood d18:1-16:0-SM+blood 0 0 0.511794872 serum_phospholipids serum_phospholipids 0.94 0.14 no no no no no no d18:1-14:1-SM+blood d18:1-16:0-SM+blood 0 0 0.491965812 serum_phospholipids serum_phospholipids 0.0952 0.14 no dn no no no no Dopaminergic synapse d18:1-16:0-SM+blood 0 0 0.416153846 kegg serum_phospholipids NA 0.14 no up no no no no Endocrine resistance d18:1-16:0-SM+blood 0 0.517647059 0 kegg serum_phospholipids NA 0.14 no no no no no no Epstein-Barr virus infection d18:1-16:0-SM+blood 0 -0.605882353 0 kegg serum_phospholipids NA 0.14 no no no no no no ErbB signaling pathway d18:1-16:0-SM+blood 0 0.5 0 kegg serum_phospholipids NA 0.14 no no no no no no FoxO signaling pathway d18:1-16:0-SM+blood 0 0 -0.400769231 kegg serum_phospholipids NA 0.14 no no no no no no Gastric cancer d18:1-16:0-SM+blood -0.470175439 0 0 kegg serum_phospholipids NA 0.14 no no no no no no GDCA+stool d18:1-16:0-SM+blood 0.642857143 0 0 stool_bileacids serum_phospholipids 0.656 0.14 no no no no no no Gemmiger d18:1-16:0-SM+blood 0 0.503687024 0 butyrate-producing Genus serum_phospholipids 0.595 0.14 no no no no no no GnRH signaling pathway d18:1-16:0-SM+blood 0 0 0.424615385 kegg serum_phospholipids NA 0.14 no no no no no no "Growth hormone synthesis, secretion and action" d18:1-16:0-SM+blood 0 0.511764706 0 kegg serum_phospholipids NA 0.14 no no no no no no Herpes simplex virus 1 infection d18:1-16:0-SM+blood 0 -0.635294118 0 kegg serum_phospholipids NA 0.14 no no no no no no Human cytomegalovirus infection d18:1-16:0-SM+blood 0 -0.544117647 0 kegg serum_phospholipids NA 0.14 no no dn no no no Human immunodeficiency virus 1 infection d18:1-16:0-SM+blood 0 -0.564705882 0 kegg serum_phospholipids NA 0.14 no no no no no no Human T-cell leukemia virus 1 infection d18:1-16:0-SM+blood 0 -0.620588235 0 kegg serum_phospholipids NA 0.14 no no no no no no Long-term depression d18:1-16:0-SM+blood 0 0 0.411538462 kegg serum_phospholipids NA 0.14 no no no no no no Longevity regulating pathway - multiple species d18:1-16:0-SM+blood 0 0 -0.433076923 kegg serum_phospholipids NA 0.14 no no no no no no Malaria d18:1-16:0-SM+blood -0.489473684 0 0 kegg serum_phospholipids NA 0.14 no no no no no no Mineral absorption d18:1-16:0-SM+blood -0.514035088 0 0 kegg serum_phospholipids NA 0.14 no no no no no no Pancreatic secretion d18:1-16:0-SM+blood 0 0 0.420769231 kegg serum_phospholipids NA 0.14 no no no no no no Peroxisome d18:1-16:0-SM+blood 0 0 -0.499230769 kegg serum_phospholipids NA 0.14 no no no no no no Signaling pathways regulating pluripotency of stem cells d18:1-16:0-SM+blood 0 0.517647059 0 kegg serum_phospholipids NA 0.14 no no no no no no TDCA+stool d18:1-16:0-SM+blood 0 -0.646686526 0 stool_bileacids serum_phospholipids 0.963 0.14 no no no no no no 14:0/18:2-PC+blood d18:1-16:1-SM+blood 0 0 0.444786325 serum_phospholipids serum_phospholipids 0.102 0.2 no up no no no no 14:0/20:4-PC+blood d18:1-16:1-SM+blood 0 0 0.628717949 serum_phospholipids serum_phospholipids 0.486 0.2 no no no no no no 14:1/18:2-PG+blood d18:1-16:1-SM+blood 0 0 0.477606838 serum_phospholipids serum_phospholipids 0.00259 0.2 no up up no no no 16:0-LPC+blood d18:1-16:1-SM+blood 0 0 0.454358974 serum_phospholipids serum_phospholipids 0.00456 0.2 up up no no no no 16:0/14:0-PC+blood d18:1-16:1-SM+blood -0.490225564 -0.485294118 0 serum_phospholipids serum_phospholipids 0.0206 0.2 no up up no no no 16:0/18:1-PC+blood d18:1-16:1-SM+blood 0 -0.68872549 -0.531623932 serum_phospholipids serum_phospholipids 6.15E-07 0.2 up up up no no no 16:0/18:2-PC+blood d18:1-16:1-SM+blood -0.643609023 -0.769607843 -0.824273504 serum_phospholipids serum_phospholipids 3.24E-06 0.2 no up up no no no 16:0/20:3-PC+blood d18:1-16:1-SM+blood -0.484210526 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.2 no up up no no no 16:0/20:4-PC+blood d18:1-16:1-SM+blood 0 0 -0.445470085 serum_phospholipids serum_phospholipids 0.0262 0.2 no up no no no no 16:0/22:6-PC+blood d18:1-16:1-SM+blood 0 0 -0.633504274 serum_phospholipids serum_phospholipids 4.53E-05 0.2 no up up no no no 16:0/22:6-PE+blood d18:1-16:1-SM+blood 0.493233083 0 0 serum_phospholipids serum_phospholipids 0.000934 0.2 up up no no no no 16:1/16:0-PC+blood d18:1-16:1-SM+blood -0.467669173 -0.485294118 -0.633504274 serum_phospholipids serum_phospholipids 0.0215 0.2 no up up no no no 18:0-LPC+blood d18:1-16:1-SM+blood 0 0.573529412 0 serum_phospholipids serum_phospholipids 0.554 0.2 no no no no no no 18:0-LPE+blood d18:1-16:1-SM+blood 0 0.482843137 0.429059829 serum_phospholipids serum_phospholipids 0.491 0.2 no no no no no no 18:0/16:0-PC+blood d18:1-16:1-SM+blood 0 -0.656862745 -0.536410256 serum_phospholipids serum_phospholipids 9.64E-07 0.2 up up up no no no 18:0/18:2-PC+blood d18:1-16:1-SM+blood -0.589473684 -0.566176471 -0.55965812 serum_phospholipids serum_phospholipids 1.74E-06 0.2 no up up no no no 18:0/22:6-PC+blood d18:1-16:1-SM+blood 0 0 -0.522735043 serum_phospholipids serum_phospholipids 0.0775 0.2 no no up no no no 18:1/16:0-PC+blood d18:1-16:1-SM+blood -0.62406015 -0.732843137 -0.822222222 serum_phospholipids serum_phospholipids 2.43E-05 0.2 no up up no no no 18:1/18:0-PC+blood d18:1-16:1-SM+blood -0.554887218 -0.56372549 -0.56991453 serum_phospholipids serum_phospholipids 1.83E-06 0.2 no up up no no no 18:1/20:4-PC+blood d18:1-16:1-SM+blood 0 0 -0.405128205 serum_phospholipids serum_phospholipids 0.582 0.2 no no no no no no 18:1/20:4-PE+blood d18:1-16:1-SM+blood 0.452631579 0 0 serum_phospholipids serum_phospholipids 0.0578 0.2 up no no no no no 18:1/22:6-PE+blood d18:1-16:1-SM+blood 0 0 -0.51042735 serum_phospholipids serum_phospholipids 0.0047 0.2 no up no no no no 18:2/16:0-PC+blood d18:1-16:1-SM+blood 0 -0.605392157 0 serum_phospholipids serum_phospholipids 8.67E-05 0.2 no up up no no no 18:3n6+blood d18:1-16:1-SM+blood 0 0 0.495384615 serum_fattyacid serum_phospholipids 0.0463 0.2 up no dn no no no 20:0-LPC+blood d18:1-16:1-SM+blood 0 0.551470588 0 serum_phospholipids serum_phospholipids 0.199 0.2 no no no no no no 20:0/20:4-PE+blood d18:1-16:1-SM+blood 0.482706767 0 0 serum_phospholipids serum_phospholipids 0.00128 0.2 up up no no no no 20:1/20:4-PC+blood d18:1-16:1-SM+blood -0.472180451 0 -0.55008547 serum_phospholipids serum_phospholipids 0.0419 0.2 no no up no no no 20:1/20:4-PE+blood d18:1-16:1-SM+blood 0.628571429 0 0 serum_phospholipids serum_phospholipids 0.0042 0.2 up up no no no no 20:2/18:1-PE+blood d18:1-16:1-SM+blood 0.485714286 0 0 serum_phospholipids serum_phospholipids 0.00208 0.2 up up no no no no 20:2/18:3-PE+blood d18:1-16:1-SM+blood 0.545864662 0 0 serum_phospholipids serum_phospholipids 0.0391 0.2 up up no no no no 20:3/16:0-PC+blood d18:1-16:1-SM+blood 0 0 -0.522051282 serum_phospholipids serum_phospholipids 0.00405 0.2 no up up no no no 20:5/18:0-PC+blood d18:1-16:1-SM+blood 0 0 -0.629401709 serum_phospholipids serum_phospholipids 3.97E-06 0.2 no up up no no no 22:0/16:0-PE+blood d18:1-16:1-SM+blood 0 -0.482843137 0 serum_phospholipids serum_phospholipids 0.091 0.2 no no up no no no 24:1+blood d18:1-16:1-SM+blood 0 -0.507352941 0 serum_fattyacid serum_phospholipids 0.00582 0.2 no dn dn no no no Adrenergic signaling in cardiomyocytes d18:1-16:1-SM+blood 0 0.576470588 0 kegg serum_phospholipids NA 0.2 no no up no no no Alcoholism d18:1-16:1-SM+blood 0 0 0.474615385 kegg serum_phospholipids NA 0.2 no no no no no no Aldosterone synthesis and secretion d18:1-16:1-SM+blood 0 0 0.482307692 kegg serum_phospholipids NA 0.2 no up up no no no Alistipes d18:1-16:1-SM+blood 0 0.506437863 0 Genus serum_phospholipids 0.0114 0.2 no up no no no no Alzheimer disease d18:1-16:1-SM+blood 0 0 0.406153846 kegg serum_phospholipids NA 0.2 no no no no no no Amphetamine addiction d18:1-16:1-SM+blood 0 0 0.439230769 kegg serum_phospholipids NA 0.2 no no no no no no AMPK signaling pathway d18:1-16:1-SM+blood -0.654385965 0.685294118 0 kegg serum_phospholipids NA 0.2 no no no no no no Amyotrophic lateral sclerosis d18:1-16:1-SM+blood 0 0 0.467692308 kegg serum_phospholipids NA 0.2 no no no no no no Blautia d18:1-16:1-SM+blood 0 0 0.42092872 acetate-producing Genus serum_phospholipids 1.36E-05 0.2 up dn dn no no no Calcium signaling pathway d18:1-16:1-SM+blood 0 0 0.422307692 kegg serum_phospholipids NA 0.2 no up up no no no capric acid C6+blood d18:1-16:1-SM+blood 0 0 -0.406495726 serum_scfa serum_phospholipids 0.433 0.2 no no no no no no Cardiac muscle contraction d18:1-16:1-SM+blood 0 0 0.456153846 kegg serum_phospholipids NA 0.2 no no up no no no Central carbon metabolism in cancer d18:1-16:1-SM+blood 0 0.717647059 0 kegg serum_phospholipids NA 0.2 no no no no no no Circadian entrainment d18:1-16:1-SM+blood 0 0 0.405384615 kegg serum_phospholipids NA 0.2 no up up no no no Cocaine addiction d18:1-16:1-SM+blood 0 0 0.442307692 kegg serum_phospholipids NA 0.2 no no no no no no Collinsella d18:1-16:1-SM+blood 0 -0.517889004 0 Genus serum_phospholipids 0.128 0.2 no no no no no no Cortisol synthesis and secretion d18:1-16:1-SM+blood 0 0 0.475384615 kegg serum_phospholipids NA 0.2 no no up no no no Creatinine+blood d18:1-16:1-SM+blood 0 0 -0.487179487 serum_choline serum_phospholipids 0.437 0.2 no no no no no no d18:0-16:0-SM+blood d18:1-16:1-SM+blood 0.796992481 0.671568627 0.721709402 serum_phospholipids serum_phospholipids 0.202 0.2 no no no no no no d18:0-18:3-SM+blood d18:1-16:1-SM+blood 0.762406015 0.666666667 0.820854701 serum_phospholipids serum_phospholipids 0.0879 0.2 no dn no no no no d18:0-24:1-SM+blood d18:1-16:1-SM+blood 0.612030075 0.62254902 0.539145299 serum_phospholipids serum_phospholipids 0.0609 0.2 no dn dn no no no d18:1-14:0-SM+blood d18:1-16:1-SM+blood 0.520300752 0.656862745 0.801709402 serum_phospholipids serum_phospholipids 0.94 0.2 no no no no no no d18:1-14:1-SM+blood d18:1-16:1-SM+blood 0.557894737 0.68627451 0.794871795 serum_phospholipids serum_phospholipids 0.0952 0.2 no dn no no no no d18:1-16:0-SM+blood d18:1-16:1-SM+blood 0.783458647 0.620098039 0.714871795 serum_phospholipids serum_phospholipids 0.14 0.2 no no no no no no Diabetic cardiomyopathy d18:1-16:1-SM+blood 0 0 0.424615385 kegg serum_phospholipids NA 0.2 no no no no no no EGFR tyrosine kinase inhibitor resistance d18:1-16:1-SM+blood 0 0.523529412 0 kegg serum_phospholipids NA 0.2 no no no no no no Endocrine and other factor-regulated calcium reabsorption d18:1-16:1-SM+blood 0 0 0.450769231 kegg serum_phospholipids NA 0.2 no no no no no no Faecalibacterium d18:1-16:1-SM+blood 0 -0.551470588 0 butyrate-producing Genus serum_phospholipids 0.0039 0.2 no dn dn no no no Fc gamma R-mediated phagocytosis d18:1-16:1-SM+blood 0.456140351 0 0 kegg serum_phospholipids NA 0.2 no no no no no no Ferroptosis d18:1-16:1-SM+blood -0.515789474 0 0 kegg serum_phospholipids NA 0.2 no no no no no no Gap junction d18:1-16:1-SM+blood -0.477192982 0 0.563846154 kegg serum_phospholipids NA 0.2 no no no no no no Gastric cancer d18:1-16:1-SM+blood -0.464912281 0 0 kegg serum_phospholipids NA 0.2 no no no no no no GDCA+stool d18:1-16:1-SM+blood 0.736263736 0 0 stool_bileacids serum_phospholipids 0.656 0.2 no no no no no no GnRH signaling pathway d18:1-16:1-SM+blood 0 0 0.403846154 kegg serum_phospholipids NA 0.2 no no no no no no Herpes simplex virus 1 infection d18:1-16:1-SM+blood 0 -0.502941176 0 kegg serum_phospholipids NA 0.2 no no no no no no HIF-1 signaling pathway d18:1-16:1-SM+blood -0.498245614 0 0 kegg serum_phospholipids NA 0.2 no no no no no no Inflammatory mediator regulation of TRP channels d18:1-16:1-SM+blood 0 0 0.426153846 kegg serum_phospholipids NA 0.2 no no no no no no Insulin secretion d18:1-16:1-SM+blood 0 0 0.451538462 yes kegg serum_phospholipids NA 0.2 no up up no no no Kaposi sarcoma-associated herpesvirus infection d18:1-16:1-SM+blood -0.512280702 0 0 kegg serum_phospholipids NA 0.2 no no dn no no no Lachnospira d18:1-16:1-SM+blood 0 0 -0.431507482 butyrate-producing Genus serum_phospholipids 0.279 0.2 no no no no no no Legionellosis d18:1-16:1-SM+blood 0 0.594117647 0 kegg serum_phospholipids NA 0.2 no no no no no no Lipid and atherosclerosis d18:1-16:1-SM+blood 0.566666667 0 0 kegg serum_phospholipids NA 0.2 no no no no no no Long-term depression d18:1-16:1-SM+blood 0 0 0.557692308 kegg serum_phospholipids NA 0.2 no no no no no no Longevity regulating pathway d18:1-16:1-SM+blood -0.507017544 0 0 kegg serum_phospholipids NA 0.2 no no no no no no Malaria d18:1-16:1-SM+blood -0.607017544 0 0 kegg serum_phospholipids NA 0.2 no no no no no no Mineral absorption d18:1-16:1-SM+blood -0.631578947 0 0 kegg serum_phospholipids NA 0.2 no no no no no no Mitophagy - animal d18:1-16:1-SM+blood -0.519298246 0 0 kegg serum_phospholipids NA 0.2 no no no no no no Morphine addiction d18:1-16:1-SM+blood 0 0 0.495384615 kegg serum_phospholipids NA 0.2 no up up no no no mTOR signaling pathway d18:1-16:1-SM+blood 0 0.55 0 kegg serum_phospholipids NA 0.2 no no no no no no Necroptosis d18:1-16:1-SM+blood -0.556140351 0 0 kegg serum_phospholipids NA 0.2 no no no no no no Non-alcoholic fatty liver disease d18:1-16:1-SM+blood 0 0 0.529230769 kegg serum_phospholipids NA 0.2 no no no no no no Olfactory transduction d18:1-16:1-SM+blood 0.524561404 0 0 kegg serum_phospholipids NA 0.2 no no no no no no Osteoclast differentiation d18:1-16:1-SM+blood 0.464912281 0 0 kegg serum_phospholipids NA 0.2 no no no no no no Oxidative phosphorylation d18:1-16:1-SM+blood 0 0 0.403846154 kegg serum_phospholipids NA 0.2 no no no no no no Pancreatic secretion d18:1-16:1-SM+blood 0 0 0.513846154 kegg serum_phospholipids NA 0.2 no no no no no no Phenylacetic acid+stool d18:1-16:1-SM+blood 0 0.618181818 0 stool_cometabolism serum_phospholipids 0.785 0.2 no no no no no no Proteasome d18:1-16:1-SM+blood 0 0 -0.580769231 kegg serum_phospholipids NA 0.2 no no no no no no Purine metabolism d18:1-16:1-SM+blood -0.542105263 0 0 kegg serum_phospholipids NA 0.2 no no no no no no Regulation of lipolysis in adipocytes d18:1-16:1-SM+blood 0 0 0.449230769 kegg serum_phospholipids NA 0.2 no no no no no no RNA transport d18:1-16:1-SM+blood 0 0.538235294 0 kegg serum_phospholipids NA 0.2 no no no no no no Ruminococcus d18:1-16:1-SM+blood 0 0 0.412525909 Genus serum_phospholipids 0.0679 0.2 no no dn no no no Shigellosis d18:1-16:1-SM+blood -0.494736842 0 0 kegg serum_phospholipids NA 0.2 no no no no no no Thermogenesis d18:1-16:1-SM+blood 0 0 0.409230769 kegg serum_phospholipids NA 0.2 no no no no no no Thyroid hormone synthesis d18:1-16:1-SM+blood -0.619298246 0 0.435384615 kegg serum_phospholipids NA 0.2 no no no no no no Ubiquitin mediated proteolysis d18:1-16:1-SM+blood -0.473684211 0 0 kegg serum_phospholipids NA 0.2 no no no no no no UDCA+stool d18:1-16:1-SM+blood 0 0 0.461654135 stool_bileacids serum_phospholipids 0.266 0.2 no no no no no no Vasopressin-regulated water reabsorption d18:1-16:1-SM+blood 0 0 0.507692308 kegg serum_phospholipids NA 0.2 no no no no no no 14:0-LPC+blood d18:1-18:0-SM+blood -0.476691729 -0.529411765 0 serum_phospholipids serum_phospholipids 0.00689 0.97 up up no no no no 14:0/16:0-PC+blood d18:1-18:0-SM+blood 0 -0.583333333 0 serum_phospholipids serum_phospholipids 0.0358 0.97 no up no no no no 14:0/18:0-PC+blood d18:1-18:0-SM+blood 0 -0.654411765 0 serum_phospholipids serum_phospholipids 0.00289 0.97 up up no no no no 16:0/16:0-PC+blood d18:1-18:0-SM+blood 0.527819549 0 0 serum_phospholipids serum_phospholipids 0.00079 0.97 no up up no no no 16:0/16:1-PC+blood d18:1-18:0-SM+blood 0 -0.639705882 0 serum_phospholipids serum_phospholipids 0.00283 0.97 up up no no no no 16:0/16:1-PI+blood d18:1-18:0-SM+blood -0.612030075 0 0 serum_phospholipids serum_phospholipids 0.262 0.97 no no no no no no 16:0/18:1-PC+blood d18:1-18:0-SM+blood 0.711278195 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.97 up up up no no no 16:0/18:2-PC+blood d18:1-18:0-SM+blood 0.539849624 0 0 serum_phospholipids serum_phospholipids 3.24E-06 0.97 no up up no no no 16:0/20:4-PC+blood d18:1-18:0-SM+blood 0.512781955 0 0 serum_phospholipids serum_phospholipids 0.0262 0.97 no up no no no no 16:0/20:4-PI+blood d18:1-18:0-SM+blood -0.496240602 0 0 serum_phospholipids serum_phospholipids 0.558 0.97 no no no no no no 16:0/20:5-PG+blood d18:1-18:0-SM+blood 0.520300752 0 0.435213675 serum_phospholipids serum_phospholipids 0.00656 0.97 no up no no no no 16:0/22:6-PC+blood d18:1-18:0-SM+blood 0 0.647058824 0 serum_phospholipids serum_phospholipids 4.53E-05 0.97 no up up no no no 16:1/16:0-PC+blood d18:1-18:0-SM+blood 0.721804511 0.666666667 0.413333333 serum_phospholipids serum_phospholipids 0.0215 0.97 no up up no no no 16:1/16:1-PC+blood d18:1-18:0-SM+blood 0.810526316 0 0 serum_phospholipids serum_phospholipids 0.0177 0.97 no no up no no no 16:1/18:1-PG+blood d18:1-18:0-SM+blood 0.521804511 0 0 serum_phospholipids serum_phospholipids 3.21E-05 0.97 no up up no no no 16:1/18:2-PG+blood d18:1-18:0-SM+blood 0.610526316 0 0.478290598 serum_phospholipids serum_phospholipids 1.40E-08 0.97 no up up no no no 18:0/16:0-PC+blood d18:1-18:0-SM+blood 0.763909774 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.97 up up up no no no 18:0/18:0-PE+blood d18:1-18:0-SM+blood -0.452631579 0 0 serum_phospholipids serum_phospholipids 0.00896 0.97 up up no no no no 18:0/18:0-PS+blood d18:1-18:0-SM+blood 0 0 0.414700855 serum_phospholipids serum_phospholipids 0.00617 0.97 no up no no no no 18:0/18:2-PC+blood d18:1-18:0-SM+blood 0.485714286 0 0 serum_phospholipids serum_phospholipids 1.74E-06 0.97 no up up no no no 18:0/20:2-PC+blood d18:1-18:0-SM+blood 0 0 -0.427692308 serum_phospholipids serum_phospholipids 0.733 0.97 no no no no no no 18:0/20:4-PC+blood d18:1-18:0-SM+blood 0.490225564 0.588235294 0 serum_phospholipids serum_phospholipids 0.454 0.97 no no no no no no 18:0/20:5-PC+blood d18:1-18:0-SM+blood 0 0.654411765 0 serum_phospholipids serum_phospholipids 0.17 0.97 no no no no no no 18:0/22:6-PC+blood d18:1-18:0-SM+blood 0 0.678921569 0 serum_phospholipids serum_phospholipids 0.0775 0.97 no no up no no no 18:0/22:6-PI+blood d18:1-18:0-SM+blood 0 0.487745098 0 serum_phospholipids serum_phospholipids 0.425 0.97 no no no no no no 18:1-LPE+blood d18:1-18:0-SM+blood -0.476691729 0 0 serum_phospholipids serum_phospholipids 0.117 0.97 no no no no no no 18:1/16:0-PC+blood d18:1-18:0-SM+blood 0.54887218 0 0 serum_phospholipids serum_phospholipids 2.43E-05 0.97 no up up no no no 18:1/16:0-PI+blood d18:1-18:0-SM+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.793 0.97 no no no no no no 18:1/18:0-PC+blood d18:1-18:0-SM+blood 0.457142857 0 0 serum_phospholipids serum_phospholipids 1.83E-06 0.97 no up up no no no 18:1/18:0-PS+blood d18:1-18:0-SM+blood 0.612030075 0 0 serum_phospholipids serum_phospholipids 0.193 0.97 no no no no no no 18:1/18:1-PC+blood d18:1-18:0-SM+blood 0 -0.539215686 0 serum_phospholipids serum_phospholipids 1.34E-05 0.97 no up up no no no 18:1/18:2-PG+blood d18:1-18:0-SM+blood 0.517293233 0 0.513162393 serum_phospholipids serum_phospholipids 5.58E-07 0.97 no up up no no no 18:1/20:4-PC+blood d18:1-18:0-SM+blood 0.466165414 0.62745098 0 serum_phospholipids serum_phospholipids 0.582 0.97 no no no no no no 18:2/16:0-PC+blood d18:1-18:0-SM+blood 0.57443609 0 0 serum_phospholipids serum_phospholipids 8.67E-05 0.97 no up up no no no 18:2/18:2-PC+blood d18:1-18:0-SM+blood 0 -0.50245098 0 serum_phospholipids serum_phospholipids 1.98E-05 0.97 dn up up no no no 18:2/18:2-PS+blood d18:1-18:0-SM+blood 0 -0.514705882 0.414700855 serum_phospholipids serum_phospholipids 0.00674 0.97 up up no no no no 18:3n3+blood d18:1-18:0-SM+blood 0.509774436 0 0 serum_fattyacid serum_phospholipids 0.291 0.97 no no no no no no 20:0-LPC+blood d18:1-18:0-SM+blood 0 0 -0.422905983 serum_phospholipids serum_phospholipids 0.199 0.97 no no no no no no 20:0-LPE+blood d18:1-18:0-SM+blood 0 0 -0.417435897 serum_phospholipids serum_phospholipids 0.0615 0.97 no no up no no no 20:0/20:4-PE+blood d18:1-18:0-SM+blood 0 -0.522058824 0 serum_phospholipids serum_phospholipids 0.00128 0.97 up up no no no no 20:0/20:5-PC+blood d18:1-18:0-SM+blood 0.603007519 0.620098039 0 serum_phospholipids serum_phospholipids 0.882 0.97 no no no no no no 20:1-LPE+blood d18:1-18:0-SM+blood 0 0 -0.44 serum_phospholipids serum_phospholipids 0.465 0.97 no no no no no no 20:1/20:4-PC+blood d18:1-18:0-SM+blood 0 0.649509804 0 serum_phospholipids serum_phospholipids 0.0419 0.97 no no up no no no 20:1/20:4-PE+blood d18:1-18:0-SM+blood 0.470676692 0 0 serum_phospholipids serum_phospholipids 0.0042 0.97 up up no no no no 20:1+blood d18:1-18:0-SM+blood 0 0 -0.407863248 yes serum_fattyacid serum_phospholipids 2.56E-05 0.97 dn dn dn no no no 20:2+blood d18:1-18:0-SM+blood 0 -0.524509804 0 serum_fattyacid serum_phospholipids 0.478 0.97 no no no no no no 20:3/16:0-PC+blood d18:1-18:0-SM+blood 0.544360902 0 0 serum_phospholipids serum_phospholipids 0.00405 0.97 no up up no no no 20:3/18:0-PC+blood d18:1-18:0-SM+blood 0.45112782 0.549019608 0 serum_phospholipids serum_phospholipids 0.296 0.97 no no no no no no 20:3n6+blood d18:1-18:0-SM+blood -0.476691729 -0.585784314 0 serum_fattyacid serum_phospholipids 0.0884 0.97 up no no no no no 20:4-LPC+blood d18:1-18:0-SM+blood 0 0.539215686 0 serum_phospholipids serum_phospholipids 0.949 0.97 no no no no no no 20:4n6+blood d18:1-18:0-SM+blood 0.445112782 0 0 serum_fattyacid serum_phospholipids 0.133 0.97 no no no no no no 20:5/18:0-PC+blood d18:1-18:0-SM+blood 0 0.585784314 0 serum_phospholipids serum_phospholipids 3.97E-06 0.97 no up up no no no 22:1-LPA+blood d18:1-18:0-SM+blood 0 0 -0.463931624 serum_phospholipids serum_phospholipids 0.00373 0.97 no up up no no no 22:6-LPC+blood d18:1-18:0-SM+blood 0 0.784313725 0 serum_phospholipids serum_phospholipids 0.127 0.97 no no up no no no 22:6n3+blood d18:1-18:0-SM+blood 0 0.495098039 0 serum_fattyacid serum_phospholipids 0.792 0.97 no no no no no no AA+blood d18:1-18:0-SM+blood 0.661654135 0 0 serum_ARA serum_phospholipids 0.212 0.97 no no no no no no Bacteroides d18:1-18:0-SM+blood 0 0.512254902 0 LPS-producing Genus serum_phospholipids 0.000267 0.97 dn dn up no no no Blautia d18:1-18:0-SM+blood 0 0.522058824 0 acetate-producing Genus serum_phospholipids 1.36E-05 0.97 up dn dn no no no CDCA+blood d18:1-18:0-SM+blood -0.541353383 0 0 serum_bileacids serum_phospholipids 0.506 0.97 no no no no no no cGMP-PKG signaling pathway d18:1-18:0-SM+blood 0 0 0.476923077 kegg serum_phospholipids NA 0.97 no no no no no no d18:0-18:3-SM+blood d18:1-18:0-SM+blood 0.494736842 0 0 serum_phospholipids serum_phospholipids 0.0879 0.97 no dn no no no no Epstein-Barr virus infection d18:1-18:0-SM+blood 0 -0.544117647 0 kegg serum_phospholipids NA 0.97 no no no no no no Human cytomegalovirus infection d18:1-18:0-SM+blood 0 -0.517647059 0 kegg serum_phospholipids NA 0.97 no no dn no no no Human immunodeficiency virus 1 infection d18:1-18:0-SM+blood 0 -0.511764706 0 kegg serum_phospholipids NA 0.97 no no no no no no Human T-cell leukemia virus 1 infection d18:1-18:0-SM+blood 0 -0.520588235 0 kegg serum_phospholipids NA 0.97 no no no no no no Longevity regulating pathway d18:1-18:0-SM+blood -0.464912281 0 0 kegg serum_phospholipids NA 0.97 no no no no no no Mineral absorption d18:1-18:0-SM+blood -0.547368421 0 0 kegg serum_phospholipids NA 0.97 no no no no no no Mitophagy - animal d18:1-18:0-SM+blood -0.496491228 0 0 kegg serum_phospholipids NA 0.97 no no no no no no Necroptosis d18:1-18:0-SM+blood -0.512280702 0 0 kegg serum_phospholipids NA 0.97 no no no no no no Salmonella infection d18:1-18:0-SM+blood 0.554385965 0 0 kegg serum_phospholipids NA 0.97 no no no no no no Slackia d18:1-18:0-SM+blood 0 0 -0.402933181 Genus serum_phospholipids 0.94 0.97 no no no no no no 11-HETE+blood d18:1-18:1-SM+blood 0 -0.507615708 0 serum_ARA serum_phospholipids 0.464 0.916 no no no no no no 13-HODE+blood d18:1-18:1-SM+blood 0 0 -0.55008547 serum_ARA serum_phospholipids 0.32 0.916 no no no no no no 14:0-LPC+blood d18:1-18:1-SM+blood -0.610526316 0 0 serum_phospholipids serum_phospholipids 0.00689 0.916 up up no no no no 14:0/16:0-PC+blood d18:1-18:1-SM+blood 0 -0.56127451 0 serum_phospholipids serum_phospholipids 0.0358 0.916 no up no no no no 14:0/18:0-PC+blood d18:1-18:1-SM+blood 0 -0.546568627 0 serum_phospholipids serum_phospholipids 0.00289 0.916 up up no no no no 15-HETE+blood d18:1-18:1-SM+blood 0 0 0.436744232 serum_ARA serum_phospholipids 0.819 0.916 no no no no no no 16:0-LPC+blood d18:1-18:1-SM+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 0.00456 0.916 up up no no no no 16:0/16:1-PC+blood d18:1-18:1-SM+blood 0 -0.553921569 0 serum_phospholipids serum_phospholipids 0.00283 0.916 up up no no no no 16:0/16:1-PI+blood d18:1-18:1-SM+blood -0.595488722 0 0 serum_phospholipids serum_phospholipids 0.262 0.916 no no no no no no 16:0/18:0-PS+blood d18:1-18:1-SM+blood 0 0 0.413333333 serum_phospholipids serum_phospholipids 0.377 0.916 no no no no no no 16:0/18:1-PC+blood d18:1-18:1-SM+blood 0.545864662 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.916 up up up no no no 16:0/18:2-PI+blood d18:1-18:1-SM+blood -0.521804511 0 0 serum_phospholipids serum_phospholipids 0.269 0.916 no no no no no no 16:0/20:3-PC+blood d18:1-18:1-SM+blood 0 -0.600490196 0 serum_phospholipids serum_phospholipids 5.43E-06 0.916 no up up no no no 16:0/20:4-PI+blood d18:1-18:1-SM+blood -0.458646617 0 0 serum_phospholipids serum_phospholipids 0.558 0.916 no no no no no no 16:0/20:5-PG+blood d18:1-18:1-SM+blood 0.682706767 0 0.521367521 serum_phospholipids serum_phospholipids 0.00656 0.916 no up no no no no 16:1-LPC+blood d18:1-18:1-SM+blood 0 0.617647059 0 serum_phospholipids serum_phospholipids 0.0241 0.916 no up no no no no 16:1/16:0-PC+blood d18:1-18:1-SM+blood 0.467669173 0 0 serum_phospholipids serum_phospholipids 0.0215 0.916 no up up no no no 16:1/16:1-PC+blood d18:1-18:1-SM+blood 0.763909774 0 0.401025641 serum_phospholipids serum_phospholipids 0.0177 0.916 no no up no no no 16:1/18:1-PG+blood d18:1-18:1-SM+blood 0.587969925 0 0.456410256 serum_phospholipids serum_phospholipids 3.21E-05 0.916 no up up no no no 16:1/18:2-PG+blood d18:1-18:1-SM+blood 0.527819549 0 0.439316239 serum_phospholipids serum_phospholipids 1.40E-08 0.916 no up up no no no 18:0/16:0-PC+blood d18:1-18:1-SM+blood 0.601503759 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.916 up up up no no no 18:0/20:4-PC+blood d18:1-18:1-SM+blood 0.481203008 0 0 serum_phospholipids serum_phospholipids 0.454 0.916 no no no no no no 18:0/20:4-PI+blood d18:1-18:1-SM+blood 0.527819549 0 0 serum_phospholipids serum_phospholipids 0.167 0.916 no no no no no no 18:1/18:0-PS+blood d18:1-18:1-SM+blood 0.684210526 0 0 serum_phospholipids serum_phospholipids 0.193 0.916 no no no no no no 18:1/18:1-PC+blood d18:1-18:1-SM+blood 0 -0.671568627 0 serum_phospholipids serum_phospholipids 1.34E-05 0.916 no up up no no no 18:1/18:1-PG+blood d18:1-18:1-SM+blood 0 -0.517156863 0 serum_phospholipids serum_phospholipids 0.00352 0.916 no up up no no no 18:1/18:2-PG+blood d18:1-18:1-SM+blood 0 0 0.45025641 serum_phospholipids serum_phospholipids 5.58E-07 0.916 no up up no no no 18:1/20:4-PC+blood d18:1-18:1-SM+blood 0.580451128 0.487745098 0 serum_phospholipids serum_phospholipids 0.582 0.916 no no no no no no 18:1/20:4-PE+blood d18:1-18:1-SM+blood 0.538345865 0 0 serum_phospholipids serum_phospholipids 0.0578 0.916 up no no no no no 18:2-LPE+blood d18:1-18:1-SM+blood -0.511278195 0 0 serum_phospholipids serum_phospholipids 0.112 0.916 no no no no no no 18:2/18:2-PS+blood d18:1-18:1-SM+blood 0 0 0.466666667 serum_phospholipids serum_phospholipids 0.00674 0.916 up up no no no no 18:3n6+blood d18:1-18:1-SM+blood 0 0 0.40034188 serum_fattyacid serum_phospholipids 0.0463 0.916 up no dn no no no 20:0-LPC+blood d18:1-18:1-SM+blood 0 0 -0.428376068 serum_phospholipids serum_phospholipids 0.199 0.916 no no no no no no 20:0/20:5-PC+blood d18:1-18:1-SM+blood 0.744360902 0.539215686 0 serum_phospholipids serum_phospholipids 0.882 0.916 no no no no no no 20:1/20:4-PE+blood d18:1-18:1-SM+blood 0.702255639 0 0 serum_phospholipids serum_phospholipids 0.0042 0.916 up up no no no no 20:2/18:3-PE+blood d18:1-18:1-SM+blood 0.544360902 0 0 serum_phospholipids serum_phospholipids 0.0391 0.916 up up no no no no 20:3/18:0-PC+blood d18:1-18:1-SM+blood 0.446616541 0 0 serum_phospholipids serum_phospholipids 0.296 0.916 no no no no no no 20:3/18:0-PI+blood d18:1-18:1-SM+blood 0.476691729 0 0 serum_phospholipids serum_phospholipids 0.289 0.916 no no no no no no 20:3n6+blood d18:1-18:1-SM+blood -0.473684211 -0.544117647 0 serum_fattyacid serum_phospholipids 0.0884 0.916 up no no no no no 20:4-LPE+blood d18:1-18:1-SM+blood 0.539849624 0 0 serum_phospholipids serum_phospholipids 0.552 0.916 no no no no no no 20:4/18:0-PE+blood d18:1-18:1-SM+blood 0.493233083 0 0 serum_phospholipids serum_phospholipids 0.000755 0.916 up up no no no no 20:4n6+blood d18:1-18:1-SM+blood 0.663157895 0 0 serum_fattyacid serum_phospholipids 0.133 0.916 no no no no no no 22:6-LPC+blood d18:1-18:1-SM+blood 0 0.546568627 0 serum_phospholipids serum_phospholipids 0.127 0.916 no no up no no no 8-HETE+blood d18:1-18:1-SM+blood 0.466165414 0 -0.505641026 serum_ARA serum_phospholipids 0.741 0.916 no no no no no no AA+blood d18:1-18:1-SM+blood 0.530827068 0 0 serum_ARA serum_phospholipids 0.212 0.916 no no no no no no acetic acid C2+blood d18:1-18:1-SM+blood 0 0.558823529 0 serum_scfa serum_phospholipids 0.000193 0.916 up dn no no no no Alcoholism d18:1-18:1-SM+blood 0 0 0.562307692 kegg serum_phospholipids NA 0.916 no no no no no no Antigen processing and presentation d18:1-18:1-SM+blood 0.505263158 0 0 kegg serum_phospholipids NA 0.916 no no no no no no Bifidobacterium d18:1-18:1-SM+blood 0 0 0.44093662 acetate-producing Genus serum_phospholipids 0.105 0.916 no dn no no no no CDCA+blood d18:1-18:1-SM+blood -0.52481203 0 0 serum_bileacids serum_phospholipids 0.506 0.916 no no no no no no Circadian entrainment d18:1-18:1-SM+blood 0 0 0.477692308 kegg serum_phospholipids NA 0.916 no up up no no no Cushing syndrome d18:1-18:1-SM+blood -0.492982456 0 0 kegg serum_phospholipids NA 0.916 no no up no no no d18:0-16:0-SM+blood d18:1-18:1-SM+blood 0.601503759 0.620098039 0.44 serum_phospholipids serum_phospholipids 0.202 0.916 no no no no no no d18:0-18:3-SM+blood d18:1-18:1-SM+blood 0.723308271 0.681372549 0.572649573 serum_phospholipids serum_phospholipids 0.0879 0.916 no dn no no no no d18:1-14:1-SM+blood d18:1-18:1-SM+blood 0 0 0.459145299 serum_phospholipids serum_phospholipids 0.0952 0.916 no dn no no no no d18:1-16:0-SM+blood d18:1-18:1-SM+blood 0.630075188 0.588235294 0.470769231 serum_phospholipids serum_phospholipids 0.14 0.916 no no no no no no d18:1-16:1-SM+blood d18:1-18:1-SM+blood 0 0 0.498803419 serum_phospholipids serum_phospholipids 0.2 0.916 no no no no no no d18:1-18:0-SM+blood d18:1-18:1-SM+blood 0.882706767 0.791666667 0.758632479 serum_phospholipids serum_phospholipids 0.97 0.916 no no no no no no Dopaminergic synapse d18:1-18:1-SM+blood 0 0 0.402307692 kegg serum_phospholipids NA 0.916 no up no no no no EGFR tyrosine kinase inhibitor resistance d18:1-18:1-SM+blood -0.480701754 0 0 kegg serum_phospholipids NA 0.916 no no no no no no Epstein-Barr virus infection d18:1-18:1-SM+blood 0 -0.570588235 0 kegg serum_phospholipids NA 0.916 no no no no no no FoxO signaling pathway d18:1-18:1-SM+blood 0 0 -0.402307692 kegg serum_phospholipids NA 0.916 no no no no no no Fusobacterium d18:1-18:1-SM+blood 0 0.494197275 0 Genus serum_phospholipids 0.628 0.916 no no no no no no Gap junction d18:1-18:1-SM+blood 0 0 0.429230769 kegg serum_phospholipids NA 0.916 no no no no no no Glutamatergic synapse d18:1-18:1-SM+blood 0 0 0.409230769 kegg serum_phospholipids NA 0.916 no up up no no no Herpes simplex virus 1 infection d18:1-18:1-SM+blood 0 -0.626470588 0 kegg serum_phospholipids NA 0.916 no no no no no no Human cytomegalovirus infection d18:1-18:1-SM+blood 0 -0.529411765 0 kegg serum_phospholipids NA 0.916 no no dn no no no Human immunodeficiency virus 1 infection d18:1-18:1-SM+blood 0 -0.552941176 0 kegg serum_phospholipids NA 0.916 no no no no no no Human T-cell leukemia virus 1 infection d18:1-18:1-SM+blood 0 -0.552941176 0 kegg serum_phospholipids NA 0.916 no no no no no no Intestinal immune network for IgA production d18:1-18:1-SM+blood 0 -0.520588235 0 kegg serum_phospholipids NA 0.916 no no no no no no JAK-STAT signaling pathway d18:1-18:1-SM+blood 0 0 -0.464615385 kegg serum_phospholipids NA 0.916 no no no no no no Kaposi sarcoma-associated herpesvirus infection d18:1-18:1-SM+blood -0.478947368 0 0 kegg serum_phospholipids NA 0.916 no no dn no no no Lipid and atherosclerosis d18:1-18:1-SM+blood 0.473684211 0 0 kegg serum_phospholipids NA 0.916 no no no no no no Long-term depression d18:1-18:1-SM+blood 0 0 0.405384615 kegg serum_phospholipids NA 0.916 no no no no no no Longevity regulating pathway d18:1-18:1-SM+blood -0.478947368 0 0 kegg serum_phospholipids NA 0.916 no no no no no no Mineral absorption d18:1-18:1-SM+blood -0.694736842 0 0 kegg serum_phospholipids NA 0.916 no no no no no no Mitophagy - animal d18:1-18:1-SM+blood -0.647368421 0 0 kegg serum_phospholipids NA 0.916 no no no no no no Morphine addiction d18:1-18:1-SM+blood 0 0 0.456923077 kegg serum_phospholipids NA 0.916 no up up no no no mTOR signaling pathway d18:1-18:1-SM+blood -0.533333333 0 0 kegg serum_phospholipids NA 0.916 no no no no no no Necroptosis d18:1-18:1-SM+blood -0.638596491 0 0 kegg serum_phospholipids NA 0.916 no no no no no no Propionic acid+stool d18:1-18:1-SM+blood 0 0.627272727 0 yes stool_scfa serum_phospholipids 0.0436 0.916 dn no up no no no Salmonella infection d18:1-18:1-SM+blood 0.526315789 0 0 kegg serum_phospholipids NA 0.916 no no no no no no Serotonergic synapse d18:1-18:1-SM+blood 0 0 0.45 kegg serum_phospholipids NA 0.916 no no no no no no Shigellosis d18:1-18:1-SM+blood -0.471929825 0 0 kegg serum_phospholipids NA 0.916 no no no no no no Slackia d18:1-18:1-SM+blood 0 0 -0.44367365 Genus serum_phospholipids 0.94 0.916 no no no no no no Ubiquitin mediated proteolysis d18:1-18:1-SM+blood -0.584210526 0 0 kegg serum_phospholipids NA 0.916 no no no no no no Vascular smooth muscle contraction d18:1-18:1-SM+blood 0 0 0.471538462 kegg serum_phospholipids NA 0.916 no no no no no no 11-HETE+blood d18:1-20:0-SM+blood 0 -0.570709186 0 serum_ARA serum_phospholipids 0.464 0.933 no no no no no no "12,13-EPOME+blood" d18:1-20:0-SM+blood 0 -0.579976497 0 serum_ARA serum_phospholipids 0.901 0.933 no no no no no no 14:0-LPC+blood d18:1-20:0-SM+blood 0 0 0.40034188 serum_phospholipids serum_phospholipids 0.00689 0.933 up up no no no no 14:0/18:2-PC+blood d18:1-20:0-SM+blood 0 0 0.461880342 serum_phospholipids serum_phospholipids 0.102 0.933 no up no no no no 14:0/20:4-PC+blood d18:1-20:0-SM+blood 0 0 0.501538462 serum_phospholipids serum_phospholipids 0.486 0.933 no no no no no no 14:1/18:2-PG+blood d18:1-20:0-SM+blood 0 0 0.463931624 serum_phospholipids serum_phospholipids 0.00259 0.933 no up up no no no 16:0-LPC+blood d18:1-20:0-SM+blood 0 0 0.646495726 serum_phospholipids serum_phospholipids 0.00456 0.933 up up no no no no 16:0/14:0-PC+blood d18:1-20:0-SM+blood 0 0 -0.419487179 serum_phospholipids serum_phospholipids 0.0206 0.933 no up up no no no 16:0/18:0-PC+blood d18:1-20:0-SM+blood 0 0 0.401709402 serum_phospholipids serum_phospholipids 0.521 0.933 no no no no no no 16:0/18:1-PE+blood d18:1-20:0-SM+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.000107 0.933 up up no no no no 16:0/18:2-PC+blood d18:1-20:0-SM+blood 0 0 -0.602051282 serum_phospholipids serum_phospholipids 3.24E-06 0.933 no up up no no no 16:0/18:3-PC+blood d18:1-20:0-SM+blood 0.517293233 0 0 serum_phospholipids serum_phospholipids 0.00216 0.933 no up up no no no 16:0/20:4-PC+blood d18:1-20:0-SM+blood 0 0 -0.428376068 serum_phospholipids serum_phospholipids 0.0262 0.933 no up no no no no 16:1/16:0-PC+blood d18:1-20:0-SM+blood 0 0 -0.558974359 serum_phospholipids serum_phospholipids 0.0215 0.933 no up up no no no 18:0-LPC+blood d18:1-20:0-SM+blood 0 0 0.47965812 serum_phospholipids serum_phospholipids 0.554 0.933 no no no no no no 18:0/18:0-PE+blood d18:1-20:0-SM+blood 0 0 0.424957265 serum_phospholipids serum_phospholipids 0.00896 0.933 up up no no no no 18:0/20:2-PC+blood d18:1-20:0-SM+blood 0 0 0.455042735 serum_phospholipids serum_phospholipids 0.733 0.933 no no no no no no 18:0/20:4-PC+blood d18:1-20:0-SM+blood 0 0.544117647 0 serum_phospholipids serum_phospholipids 0.454 0.933 no no no no no no 18:0/20:5-PC+blood d18:1-20:0-SM+blood 0 0.536764706 0 serum_phospholipids serum_phospholipids 0.17 0.933 no no no no no no 18:1/16:0-PC+blood d18:1-20:0-SM+blood 0 0 -0.606153846 serum_phospholipids serum_phospholipids 2.43E-05 0.933 no up up no no no 18:1/16:1-PE+blood d18:1-20:0-SM+blood 0 -0.517156863 0 serum_phospholipids serum_phospholipids 0.000184 0.933 up up no no no no 18:1/18:0-PE+blood d18:1-20:0-SM+blood 0 -0.512254902 0 serum_phospholipids serum_phospholipids 1.39E-06 0.933 up up no no no no 18:1/18:1-PC+blood d18:1-20:0-SM+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 1.34E-05 0.933 no up up no no no 18:1/18:1-PE+blood d18:1-20:0-SM+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 1.03E-05 0.933 up up no no no no 18:1/20:4-PC+blood d18:1-20:0-SM+blood 0 0.573529412 0 serum_phospholipids serum_phospholipids 0.582 0.933 no no no no no no 18:1/20:4-PE+blood d18:1-20:0-SM+blood 0.497744361 0 0 serum_phospholipids serum_phospholipids 0.0578 0.933 up no no no no no 18:2-LPE+blood d18:1-20:0-SM+blood 0 -0.482843137 0 serum_phospholipids serum_phospholipids 0.112 0.933 no no no no no no 18:2n6c+blood d18:1-20:0-SM+blood 0 -0.495098039 0 serum_fattyacid serum_phospholipids 0.15 0.933 no no no no no no 18:3/18:2-PC+blood d18:1-20:0-SM+blood 0.478195489 0 0 serum_phospholipids serum_phospholipids 0.0394 0.933 no no up no no no 20:0-LPC+blood d18:1-20:0-SM+blood 0 0 0.594529915 serum_phospholipids serum_phospholipids 0.199 0.933 no no no no no no 20:0/20:5-PC+blood d18:1-20:0-SM+blood 0 0.68627451 0 serum_phospholipids serum_phospholipids 0.882 0.933 no no no no no no 20:1/20:4-PE+blood d18:1-20:0-SM+blood 0.556390977 0 0 serum_phospholipids serum_phospholipids 0.0042 0.933 up up no no no no 20:2+blood d18:1-20:0-SM+blood 0 -0.529411765 0 serum_fattyacid serum_phospholipids 0.478 0.933 no no no no no no 20:3/16:0-PC+blood d18:1-20:0-SM+blood 0 0 -0.462564103 serum_phospholipids serum_phospholipids 0.00405 0.933 no up up no no no 20:4-LPC+blood d18:1-20:0-SM+blood 0 0.578431373 0 serum_phospholipids serum_phospholipids 0.949 0.933 no no no no no no 24:0+blood d18:1-20:0-SM+blood 0.545864662 0 0 serum_fattyacid serum_phospholipids 0.034 0.933 dn no up no no no 8-HETE+blood d18:1-20:0-SM+blood 0.463157895 0 0 serum_ARA serum_phospholipids 0.741 0.933 no no no no no no Acute myeloid leukemia d18:1-20:0-SM+blood -0.461403509 0 0 kegg serum_phospholipids NA 0.933 no no no no no no Antigen processing and presentation d18:1-20:0-SM+blood 0.642105263 -0.573529412 0 kegg serum_phospholipids NA 0.933 no no no no no no Bacteroides d18:1-20:0-SM+blood 0 0.487745098 0 LPS-producing Genus serum_phospholipids 0.000267 0.933 dn dn up no no no Collinsella d18:1-20:0-SM+blood 0 -0.489528416 0 Genus serum_phospholipids 0.128 0.933 no no no no no no d18:0-16:0-SM+blood d18:1-20:0-SM+blood 0.693233083 0.796568627 0.548034188 serum_phospholipids serum_phospholipids 0.202 0.933 no no no no no no d18:0-18:3-SM+blood d18:1-20:0-SM+blood 0.813533835 0.669117647 0.503589744 serum_phospholipids serum_phospholipids 0.0879 0.933 no dn no no no no d18:0-24:1-SM+blood d18:1-20:0-SM+blood 0 0.549019608 0.45982906 serum_phospholipids serum_phospholipids 0.0609 0.933 no dn dn no no no d18:1-14:0-SM+blood d18:1-20:0-SM+blood 0.547368421 0.661764706 0.730598291 serum_phospholipids serum_phospholipids 0.94 0.933 no no no no no no d18:1-14:1-SM+blood d18:1-20:0-SM+blood 0.618045113 0.580882353 0.481025641 serum_phospholipids serum_phospholipids 0.0952 0.933 no dn no no no no d18:1-16:0-SM+blood d18:1-20:0-SM+blood 0.697744361 0.781862745 0.515213675 serum_phospholipids serum_phospholipids 0.14 0.933 no no no no no no d18:1-16:1-SM+blood d18:1-20:0-SM+blood 0.634586466 0.676470588 0.633504274 serum_phospholipids serum_phospholipids 0.2 0.933 no no no no no no d18:1-18:0-SM+blood d18:1-20:0-SM+blood 0.467669173 0.578431373 0 serum_phospholipids serum_phospholipids 0.97 0.933 no no no no no no d18:1-18:1-SM+blood d18:1-20:0-SM+blood 0.633082707 0.664215686 0 serum_phospholipids serum_phospholipids 0.916 0.933 no no no no no no Dorea d18:1-20:0-SM+blood 0 0 0.503948077 Genus serum_phospholipids 0.00362 0.933 up no dn no no no Epstein-Barr virus infection d18:1-20:0-SM+blood 0.5 -0.655882353 0 kegg serum_phospholipids NA 0.933 no no no no no no Ferroptosis d18:1-20:0-SM+blood -0.535087719 0 0 kegg serum_phospholipids NA 0.933 no no no no no no Gastric cancer d18:1-20:0-SM+blood -0.549122807 0 0 kegg serum_phospholipids NA 0.933 no no no no no no GDCA+stool d18:1-20:0-SM+blood 0.598901099 0 0 stool_bileacids serum_phospholipids 0.656 0.933 no no no no no no "Growth hormone synthesis, secretion and action" d18:1-20:0-SM+blood -0.489473684 0 0 kegg serum_phospholipids NA 0.933 no no no no no no HCA+stool d18:1-20:0-SM+blood 0.653846154 0 0 stool_bileacids serum_phospholipids 0.155 0.933 no no no no no no Herpes simplex virus 1 infection d18:1-20:0-SM+blood 0.571929825 -0.655882353 0 kegg serum_phospholipids NA 0.933 no no no no no no Human cytomegalovirus infection d18:1-20:0-SM+blood 0.540350877 -0.644117647 0 kegg serum_phospholipids NA 0.933 no no dn no no no Human immunodeficiency virus 1 infection d18:1-20:0-SM+blood 0.526315789 -0.641176471 0 kegg serum_phospholipids NA 0.933 no no no no no no Human T-cell leukemia virus 1 infection d18:1-20:0-SM+blood 0.649122807 -0.644117647 0 kegg serum_phospholipids NA 0.933 no no no no no no Leishmaniasis d18:1-20:0-SM+blood 0.505263158 0 0 kegg serum_phospholipids NA 0.933 no no no no no no Long-term depression d18:1-20:0-SM+blood -0.461403509 0 0 kegg serum_phospholipids NA 0.933 no no no no no no Longevity regulating pathway d18:1-20:0-SM+blood -0.696491228 0 0 kegg serum_phospholipids NA 0.933 no no no no no no MAPK signaling pathway d18:1-20:0-SM+blood 0 0 -0.425384615 kegg serum_phospholipids NA 0.933 no no no no no no Mineral absorption d18:1-20:0-SM+blood -0.736842105 0 0 kegg serum_phospholipids NA 0.933 no no no no no no Mitophagy - animal d18:1-20:0-SM+blood -0.563157895 0 0 kegg serum_phospholipids NA 0.933 no no no no no no Necroptosis d18:1-20:0-SM+blood -0.71754386 0 0 kegg serum_phospholipids NA 0.933 no no no no no no nutriCA+stool d18:1-20:0-SM+blood 0.664835165 0 0 stool_bileacids serum_phospholipids 0.481 0.933 no no no no no no Paraprevotella d18:1-20:0-SM+blood 0.481179359 0 0.408895201 Genus serum_phospholipids 0.118 0.933 no no no no no no Pathways of neurodegeneration - multiple diseases d18:1-20:0-SM+blood 0 0 0.446153846 kegg serum_phospholipids NA 0.933 no no no no no no Pertussis d18:1-20:0-SM+blood 0.468421053 0 0 kegg serum_phospholipids NA 0.933 no no dn no no no Phenylacetic acid+stool d18:1-20:0-SM+blood 0 0.627272727 0 stool_cometabolism serum_phospholipids 0.785 0.933 no no no no no no Prolactin signaling pathway d18:1-20:0-SM+blood 0 0 -0.41 kegg serum_phospholipids NA 0.933 no no no no no no Regulation of actin cytoskeleton d18:1-20:0-SM+blood 0.489473684 0 0 kegg serum_phospholipids NA 0.933 no no no no no no Salmonella infection d18:1-20:0-SM+blood 0.580701754 0 0 kegg serum_phospholipids NA 0.933 no no no no no no TCA+stool d18:1-20:0-SM+blood 0 -0.636363636 0 stool_bileacids serum_phospholipids 0.458 0.933 no no no no no no Thyroid hormone synthesis d18:1-20:0-SM+blood 0 0 0.448461538 kegg serum_phospholipids NA 0.933 no no no no no no Ubiquitin mediated proteolysis d18:1-20:0-SM+blood -0.48245614 0 0 kegg serum_phospholipids NA 0.933 no no no no no no 11-HETE+blood d18:1-20:1-SM+blood 0 -0.745650193 0 serum_ARA serum_phospholipids 0.464 0.0992 no no no no no no "12,13-EPOME+blood" d18:1-20:1-SM+blood 0 -0.529870536 0 serum_ARA serum_phospholipids 0.901 0.0992 no no no no no no 13-HODE+blood d18:1-20:1-SM+blood 0 0 -0.436581197 serum_ARA serum_phospholipids 0.32 0.0992 no no no no no no 14:0/16:0-PC+blood d18:1-20:1-SM+blood 0 -0.75 0 serum_phospholipids serum_phospholipids 0.0358 0.0992 no up no no no no 14:0/18:0-PC+blood d18:1-20:1-SM+blood 0 -0.725490196 0 serum_phospholipids serum_phospholipids 0.00289 0.0992 up up no no no no 14:0+blood d18:1-20:1-SM+blood 0 -0.56127451 0 yes serum_fattyacid serum_phospholipids 0.00572 0.0992 up no dn no no no 16:0/16:1-PC+blood d18:1-20:1-SM+blood 0 -0.754901961 0 serum_phospholipids serum_phospholipids 0.00283 0.0992 up up no no no no 16:0/16:1-PI+blood d18:1-20:1-SM+blood -0.587969925 -0.549019608 0 serum_phospholipids serum_phospholipids 0.262 0.0992 no no no no no no 16:0/18:1-PE+blood d18:1-20:1-SM+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.000107 0.0992 up up no no no no 16:0/18:2-PI+blood d18:1-20:1-SM+blood -0.461654135 0 0 serum_phospholipids serum_phospholipids 0.269 0.0992 no no no no no no 16:0/20:4-PI+blood d18:1-20:1-SM+blood -0.514285714 0 0 serum_phospholipids serum_phospholipids 0.558 0.0992 no no no no no no 16:0/20:5-PG+blood d18:1-20:1-SM+blood 0.454135338 0 0.478974359 serum_phospholipids serum_phospholipids 0.00656 0.0992 no up no no no no 16:1/16:1-PC+blood d18:1-20:1-SM+blood 0.506766917 0 0 serum_phospholipids serum_phospholipids 0.0177 0.0992 no no up no no no 16:1/18:2-PG+blood d18:1-20:1-SM+blood 0.553383459 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.0992 no up up no no no 18:0/16:0-PC+blood d18:1-20:1-SM+blood 0.448120301 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.0992 up up up no no no 18:0/18:0-PE+blood d18:1-20:1-SM+blood 0 -0.519607843 0 serum_phospholipids serum_phospholipids 0.00896 0.0992 up up no no no no 18:0/18:1-PE+blood d18:1-20:1-SM+blood 0 -0.485294118 0 serum_phospholipids serum_phospholipids 0.00716 0.0992 up up no no no no 18:0/20:4-PC+blood d18:1-20:1-SM+blood 0 0.595588235 0 serum_phospholipids serum_phospholipids 0.454 0.0992 no no no no no no 18:0/20:5-PC+blood d18:1-20:1-SM+blood 0 0.644607843 0 serum_phospholipids serum_phospholipids 0.17 0.0992 no no no no no no 18:1-LPC+blood d18:1-20:1-SM+blood 0 0.566176471 0 serum_phospholipids serum_phospholipids 0.179 0.0992 no no no no no no 18:1/16:1-PE+blood d18:1-20:1-SM+blood 0 -0.519607843 0 serum_phospholipids serum_phospholipids 0.000184 0.0992 up up no no no no 18:1/18:0-PE+blood d18:1-20:1-SM+blood 0 -0.490196078 0 serum_phospholipids serum_phospholipids 1.39E-06 0.0992 up up no no no no 18:1/18:0-PS+blood d18:1-20:1-SM+blood 0.560902256 0 0 serum_phospholipids serum_phospholipids 0.193 0.0992 no no no no no no 18:1/18:1-PC+blood d18:1-20:1-SM+blood 0 -0.585784314 0 serum_phospholipids serum_phospholipids 1.34E-05 0.0992 no up up no no no 18:1/18:1-PE+blood d18:1-20:1-SM+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 1.03E-05 0.0992 up up no no no no 18:1/18:1-PG+blood d18:1-20:1-SM+blood 0 -0.551470588 0 serum_phospholipids serum_phospholipids 0.00352 0.0992 no up up no no no 18:1/18:2-PG+blood d18:1-20:1-SM+blood 0.490225564 0 0.506324786 serum_phospholipids serum_phospholipids 5.58E-07 0.0992 no up up no no no 18:1/20:4-PC+blood d18:1-20:1-SM+blood 0 0.676470588 0 serum_phospholipids serum_phospholipids 0.582 0.0992 no no no no no no 18:2/18:2-PS+blood d18:1-20:1-SM+blood 0 -0.531862745 0 serum_phospholipids serum_phospholipids 0.00674 0.0992 up up no no no no 20:0/20:5-PC+blood d18:1-20:1-SM+blood 0 0.534313725 0 serum_phospholipids serum_phospholipids 0.882 0.0992 no no no no no no 20:1-LPC+blood d18:1-20:1-SM+blood 0 0.509803922 0 serum_phospholipids serum_phospholipids 0.217 0.0992 no no no no no no 20:1/20:4-PE+blood d18:1-20:1-SM+blood 0.514285714 0 0 serum_phospholipids serum_phospholipids 0.0042 0.0992 up up no no no no 20:1+blood d18:1-20:1-SM+blood 0.491729323 0 0 yes serum_fattyacid serum_phospholipids 2.56E-05 0.0992 dn dn dn no no no 20:3n6+blood d18:1-20:1-SM+blood 0 -0.612745098 0 serum_fattyacid serum_phospholipids 0.0884 0.0992 up no no no no no 20:4-LPC+blood d18:1-20:1-SM+blood 0 0.590686275 0.575384615 serum_phospholipids serum_phospholipids 0.949 0.0992 no no no no no no 20:4-LPE+blood d18:1-20:1-SM+blood 0 0 0.535042735 serum_phospholipids serum_phospholipids 0.552 0.0992 no no no no no no 8-HETE+blood d18:1-20:1-SM+blood 0.538345865 0 0 serum_ARA serum_phospholipids 0.741 0.0992 no no no no no no AA+blood d18:1-20:1-SM+blood 0.556390977 0 0 serum_ARA serum_phospholipids 0.212 0.0992 no no no no no no acetic acid C2+blood d18:1-20:1-SM+blood 0 0.558823529 0 serum_scfa serum_phospholipids 0.000193 0.0992 up dn no no no no Antigen processing and presentation d18:1-20:1-SM+blood 0.49122807 0 0 kegg serum_phospholipids NA 0.0992 no no no no no no d18:0-16:0-SM+blood d18:1-20:1-SM+blood 0.612030075 0.642156863 0 serum_phospholipids serum_phospholipids 0.202 0.0992 no no no no no no d18:0-18:3-SM+blood d18:1-20:1-SM+blood 0.604511278 0.566176471 0.52957265 serum_phospholipids serum_phospholipids 0.0879 0.0992 no dn no no no no d18:1-16:0-SM+blood d18:1-20:1-SM+blood 0.621052632 0.656862745 0 serum_phospholipids serum_phospholipids 0.14 0.0992 no no no no no no d18:1-18:0-SM+blood d18:1-20:1-SM+blood 0.72481203 0.767156863 0.556239316 serum_phospholipids serum_phospholipids 0.97 0.0992 no no no no no no d18:1-18:1-SM+blood d18:1-20:1-SM+blood 0.819548872 0.794117647 0.644444444 serum_phospholipids serum_phospholipids 0.916 0.0992 no no no no no no d18:1-20:0-SM+blood d18:1-20:1-SM+blood 0.621052632 0.757352941 0 serum_phospholipids serum_phospholipids 0.933 0.0992 no no no no no no Epstein-Barr virus infection d18:1-20:1-SM+blood 0 -0.558823529 0 kegg serum_phospholipids NA 0.0992 no no no no no no GCDCA+stool d18:1-20:1-SM+blood 0 -0.7 0 yes stool_bileacids serum_phospholipids 0.0471 0.0992 no dn no no no no Herpes simplex virus 1 infection d18:1-20:1-SM+blood 0 -0.567647059 0 kegg serum_phospholipids NA 0.0992 no no no no no no Human T-cell leukemia virus 1 infection d18:1-20:1-SM+blood 0.478947368 -0.544117647 0 kegg serum_phospholipids NA 0.0992 no no no no no no Intestinal immune network for IgA production d18:1-20:1-SM+blood 0 -0.505882353 0 kegg serum_phospholipids NA 0.0992 no no no no no no Mineral absorption d18:1-20:1-SM+blood -0.498245614 0 0 kegg serum_phospholipids NA 0.0992 no no no no no no mTOR signaling pathway d18:1-20:1-SM+blood -0.505263158 0 0 kegg serum_phospholipids NA 0.0992 no no no no no no Phenylacetic acid+stool d18:1-20:1-SM+blood 0.725274725 0.790909091 0 stool_cometabolism serum_phospholipids 0.785 0.0992 no no no no no no Propionic acid+stool d18:1-20:1-SM+blood 0 0.663636364 0 yes stool_scfa serum_phospholipids 0.0436 0.0992 dn no up no no no TCA+stool d18:1-20:1-SM+blood 0 -0.7 0 stool_bileacids serum_phospholipids 0.458 0.0992 no no no no no no Th17 cell differentiation d18:1-20:1-SM+blood 0 0 -0.425384615 kegg serum_phospholipids NA 0.0992 no no no no no no total_stool_scfa+stool d18:1-20:1-SM+blood 0 0.772727273 0 stool_scfa serum_phospholipids 0.0534 0.0992 dn no up no no no Yersinia infection d18:1-20:1-SM+blood 0.487719298 0 0 kegg serum_phospholipids NA 0.0992 no no no no no no 12-ketoDCA+blood d18:1-22:0-SM+blood 0 0.487390898 0 serum_bileacids serum_phospholipids 0.517 0.522 no no no no no no "12,13-EPOME+blood" d18:1-22:0-SM+blood 0.454050311 0 0 serum_ARA serum_phospholipids 0.901 0.522 no no no no no no 14:0/20:4-PC+blood d18:1-22:0-SM+blood 0 0 0.421538462 serum_phospholipids serum_phospholipids 0.486 0.522 no no no no no no 14:0+blood d18:1-22:0-SM+blood 0 -0.485294118 0 yes serum_fattyacid serum_phospholipids 0.00572 0.522 up no dn no no no 16:0/18:2-PC+blood d18:1-22:0-SM+blood 0 0 -0.465982906 serum_phospholipids serum_phospholipids 3.24E-06 0.522 no up up no no no 16:0/22:6-PE+blood d18:1-22:0-SM+blood 0 0 -0.419487179 serum_phospholipids serum_phospholipids 0.000934 0.522 up up no no no no 16:1/16:0-PC+blood d18:1-22:0-SM+blood 0 0 -0.611623932 serum_phospholipids serum_phospholipids 0.0215 0.522 no up up no no no 16:1/16:1-PC+blood d18:1-22:0-SM+blood 0 0 -0.673846154 serum_phospholipids serum_phospholipids 0.0177 0.522 no no up no no no 18:0/18:0-PC+blood d18:1-22:0-SM+blood 0 0.549019608 0.476923077 serum_phospholipids serum_phospholipids 0.426 0.522 no no no no no no 18:0/18:1-PC+blood d18:1-22:0-SM+blood 0 0.529411765 0.503589744 serum_phospholipids serum_phospholipids 0.393 0.522 no no no no no no 18:0/20:2-PC+blood d18:1-22:0-SM+blood 0 0.774509804 0.742222222 serum_phospholipids serum_phospholipids 0.733 0.522 no no no no no no 18:1-LPC+blood d18:1-22:0-SM+blood 0 0 0.445470085 serum_phospholipids serum_phospholipids 0.179 0.522 no no no no no no 18:1/16:0-PC+blood d18:1-22:0-SM+blood 0 0 -0.45025641 serum_phospholipids serum_phospholipids 2.43E-05 0.522 no up up no no no 18:1/18:1-PI+blood d18:1-22:0-SM+blood 0 0 0.455726496 serum_phospholipids serum_phospholipids 0.111 0.522 dn no no no no no 18:1/18:2-PI+blood d18:1-22:0-SM+blood 0 -0.485294118 0 serum_phospholipids serum_phospholipids 0.0164 0.522 dn no up no no no 18:1+blood d18:1-22:0-SM+blood 0 -0.602941176 0 yes serum_fattyacid serum_phospholipids 0.00202 0.522 up no dn no no no 20:0-LPC+blood d18:1-22:0-SM+blood 0 0.485294118 0.718290598 serum_phospholipids serum_phospholipids 0.199 0.522 no no no no no no 20:0-LPE+blood d18:1-22:0-SM+blood 0.466165414 0 0 serum_phospholipids serum_phospholipids 0.0615 0.522 no no up no no no 20:0/20:5-PC+blood d18:1-22:0-SM+blood 0 0.625 0 serum_phospholipids serum_phospholipids 0.882 0.522 no no no no no no 20:1-LPC+blood d18:1-22:0-SM+blood 0 0 0.401709402 serum_phospholipids serum_phospholipids 0.217 0.522 no no no no no no 20:1+blood d18:1-22:0-SM+blood 0 0 0.402393162 yes serum_fattyacid serum_phospholipids 2.56E-05 0.522 dn dn dn no no no 24:1+blood d18:1-22:0-SM+blood -0.497744361 0 0 serum_fattyacid serum_phospholipids 0.00582 0.522 no dn dn no no no "9,10-EPOME+blood" d18:1-22:0-SM+blood 0.490128712 0 0 serum_ARA serum_phospholipids 0.801 0.522 no no no no no no Butyric acid+stool d18:1-22:0-SM+blood -0.653846154 0 0 yes stool_scfa serum_phospholipids 0.102 0.522 dn no no no no no Butyricicoccus d18:1-22:0-SM+blood 0.490524166 0 0 butyrate-producing Genus serum_phospholipids 0.852 0.522 no no no no no no Clostridium d18:1-22:0-SM+blood 0 0 -0.530742499 Genus serum_phospholipids 0.925 0.522 no no no no no no Cytosolic DNA-sensing pathway d18:1-22:0-SM+blood 0.578947368 0 0 kegg serum_phospholipids NA 0.522 no no no no no no d18:0-16:0-SM+blood d18:1-22:0-SM+blood 0.684210526 0 0.475555556 serum_phospholipids serum_phospholipids 0.202 0.522 no no no no no no d18:0-18:3-SM+blood d18:1-22:0-SM+blood 0.463157895 0 0 serum_phospholipids serum_phospholipids 0.0879 0.522 no dn no no no no d18:0-24:1-SM+blood d18:1-22:0-SM+blood 0.598496241 0.857843137 0.714871795 serum_phospholipids serum_phospholipids 0.0609 0.522 no dn dn no no no d18:1-14:0-SM+blood d18:1-22:0-SM+blood 0 0.526960784 0.508376068 serum_phospholipids serum_phospholipids 0.94 0.522 no no no no no no d18:1-14:1-SM+blood d18:1-22:0-SM+blood 0 0.583333333 0 serum_phospholipids serum_phospholipids 0.0952 0.522 no dn no no no no d18:1-16:0-SM+blood d18:1-22:0-SM+blood 0.688721805 0 0.459145299 serum_phospholipids serum_phospholipids 0.14 0.522 no no no no no no d18:1-16:1-SM+blood d18:1-22:0-SM+blood 0.512781955 0.487745098 0.422222222 serum_phospholipids serum_phospholipids 0.2 0.522 no no no no no no d18:1-20:0-SM+blood d18:1-22:0-SM+blood 0.520300752 0.605392157 0.588376068 serum_phospholipids serum_phospholipids 0.933 0.522 no no no no no no Faecalibacterium d18:1-22:0-SM+blood 0 0 0.439391355 butyrate-producing Genus serum_phospholipids 0.0039 0.522 no dn dn no no no GABAergic synapse d18:1-22:0-SM+blood 0 0 -0.427692308 kegg serum_phospholipids NA 0.522 no up up no no no Gastric cancer d18:1-22:0-SM+blood -0.461403509 0 0 kegg serum_phospholipids NA 0.522 no no no no no no Glutamatergic synapse d18:1-22:0-SM+blood -0.471929825 0 0 kegg serum_phospholipids NA 0.522 no up up no no no Hematopoietic cell lineage d18:1-22:0-SM+blood -0.485964912 0 0 kegg serum_phospholipids NA 0.522 no no no no no no Herpes simplex virus 1 infection d18:1-22:0-SM+blood 0.477192982 0 0 kegg serum_phospholipids NA 0.522 no no no no no no Human cytomegalovirus infection d18:1-22:0-SM+blood 0 0 -0.401538462 kegg serum_phospholipids NA 0.522 no no dn no no no Human T-cell leukemia virus 1 infection d18:1-22:0-SM+blood 0.48245614 0 0 kegg serum_phospholipids NA 0.522 no no no no no no IL-17 signaling pathway d18:1-22:0-SM+blood 0 0 -0.471538462 kegg serum_phospholipids NA 0.522 no no no no no no Measles d18:1-22:0-SM+blood 0.592982456 0 0 kegg serum_phospholipids NA 0.522 no no no no no no Parabacteroides d18:1-22:0-SM+blood 0 0.580882353 0 Genus serum_phospholipids 4.19E-05 0.522 no up up no no no Paraprevotella d18:1-22:0-SM+blood 0 0 0.420819241 Genus serum_phospholipids 0.118 0.522 no no no no no no 11-HETE+blood d18:1-22:1-SM+blood 0 -0.567841301 0 serum_ARA serum_phospholipids 0.464 0.222 no no no no no no 12-HEPE+blood d18:1-22:1-SM+blood 0 0 -0.45261668 serum_ARA serum_phospholipids 0.312 0.222 no no no no no no 12-ketoDCA+blood d18:1-22:1-SM+blood 0 0.490684079 0 serum_bileacids serum_phospholipids 0.517 0.222 no no no no no no "12,13-EPOME+blood" d18:1-22:1-SM+blood 0 -0.643861597 0 serum_ARA serum_phospholipids 0.901 0.222 no no no no no no 14:0/20:4-PC+blood d18:1-22:1-SM+blood 0 0 0.632136752 serum_phospholipids serum_phospholipids 0.486 0.222 no no no no no no 14:1/18:2-PG+blood d18:1-22:1-SM+blood 0 0 0.42017094 serum_phospholipids serum_phospholipids 0.00259 0.222 no up up no no no 16:0/14:0-PC+blood d18:1-22:1-SM+blood 0 -0.5 0 serum_phospholipids serum_phospholipids 0.0206 0.222 no up up no no no 16:0/18:2-PC+blood d18:1-22:1-SM+blood 0 -0.590686275 -0.602051282 serum_phospholipids serum_phospholipids 3.24E-06 0.222 no up up no no no 16:0/22:6-PC+blood d18:1-22:1-SM+blood 0 0 -0.42974359 serum_phospholipids serum_phospholipids 4.53E-05 0.222 no up up no no no 16:1/16:0-PC+blood d18:1-22:1-SM+blood 0 0 -0.653333333 serum_phospholipids serum_phospholipids 0.0215 0.222 no up up no no no 16:1/16:1-PC+blood d18:1-22:1-SM+blood 0 0 -0.496068376 serum_phospholipids serum_phospholipids 0.0177 0.222 no no up no no no 18:0-LPC+blood d18:1-22:1-SM+blood 0 0.573529412 0.498119658 serum_phospholipids serum_phospholipids 0.554 0.222 no no no no no no 18:0/18:0-PC+blood d18:1-22:1-SM+blood 0 0 0.403076923 serum_phospholipids serum_phospholipids 0.426 0.222 no no no no no no 18:0/18:1-PC+blood d18:1-22:1-SM+blood 0 0 0.414700855 serum_phospholipids serum_phospholipids 0.393 0.222 no no no no no no 18:0/18:2-PC+blood d18:1-22:1-SM+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 1.74E-06 0.222 no up up no no no 18:0/20:2-PC+blood d18:1-22:1-SM+blood 0 0 0.571282051 serum_phospholipids serum_phospholipids 0.733 0.222 no no no no no no 18:0/20:3-PC+blood d18:1-22:1-SM+blood 0 0 0.404444444 serum_phospholipids serum_phospholipids 0.0682 0.222 no up no no no no 18:1/16:0-PC+blood d18:1-22:1-SM+blood 0 -0.541666667 -0.58974359 serum_phospholipids serum_phospholipids 2.43E-05 0.222 no up up no no no 18:1/18:0-PC+blood d18:1-22:1-SM+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 1.83E-06 0.222 no up up no no no 18:1/18:1-PI+blood d18:1-22:1-SM+blood 0 0 0.418803419 serum_phospholipids serum_phospholipids 0.111 0.222 dn no no no no no 18:1/20:4-PE+blood d18:1-22:1-SM+blood 0.488721805 0 0 serum_phospholipids serum_phospholipids 0.0578 0.222 up no no no no no 18:1/22:6-PE+blood d18:1-22:1-SM+blood 0.476691729 0 0 serum_phospholipids serum_phospholipids 0.0047 0.222 no up no no no no 18:2n6c+blood d18:1-22:1-SM+blood 0 -0.504901961 0 serum_fattyacid serum_phospholipids 0.15 0.222 no no no no no no 20:0-LPC+blood d18:1-22:1-SM+blood 0 0.715686275 0.642393162 serum_phospholipids serum_phospholipids 0.199 0.222 no no no no no no 20:0/20:4-PE+blood d18:1-22:1-SM+blood 0 0 0.438632479 serum_phospholipids serum_phospholipids 0.00128 0.222 up up no no no no 20:0/20:5-PC+blood d18:1-22:1-SM+blood 0 0.49754902 0 serum_phospholipids serum_phospholipids 0.882 0.222 no no no no no no 20:1-LPC+blood d18:1-22:1-SM+blood 0.479699248 0.5 0 serum_phospholipids serum_phospholipids 0.217 0.222 no no no no no no 20:1-LPE+blood d18:1-22:1-SM+blood 0 0.529411765 0 serum_phospholipids serum_phospholipids 0.465 0.222 no no no no no no 20:1/20:4-PE+blood d18:1-22:1-SM+blood 0.622556391 0 0 serum_phospholipids serum_phospholipids 0.0042 0.222 up up no no no no 20:1+blood d18:1-22:1-SM+blood 0.542857143 0 0 yes serum_fattyacid serum_phospholipids 2.56E-05 0.222 dn dn dn no no no 20:2/18:3-PE+blood d18:1-22:1-SM+blood 0.49924812 0 0 serum_phospholipids serum_phospholipids 0.0391 0.222 up up no no no no 20:3-LPC+blood d18:1-22:1-SM+blood 0 0 0.440683761 serum_phospholipids serum_phospholipids 0.0292 0.222 no up no no no no 20:4-LPC+blood d18:1-22:1-SM+blood 0 0 0.409230769 serum_phospholipids serum_phospholipids 0.949 0.222 no no no no no no 20:4n6+blood d18:1-22:1-SM+blood 0.467669173 0 0 serum_fattyacid serum_phospholipids 0.133 0.222 no no no no no no acetic acid C2+blood d18:1-22:1-SM+blood 0 0.529411765 0 serum_scfa serum_phospholipids 0.000193 0.222 up dn no no no no Akkermansia d18:1-22:1-SM+blood 0.482820486 0 0 acetate-producing Genus serum_phospholipids 0.23 0.222 no no no no no no Alistipes d18:1-22:1-SM+blood 0 0.508890347 0 Genus serum_phospholipids 0.0114 0.222 no up no no no no AMPK signaling pathway d18:1-22:1-SM+blood -0.529824561 0 0 kegg serum_phospholipids NA 0.222 no no no no no no Antigen processing and presentation d18:1-22:1-SM+blood 0.575438596 -0.561764706 0 kegg serum_phospholipids NA 0.222 no no no no no no Butyric acid+stool d18:1-22:1-SM+blood -0.571428571 0 0 yes stool_scfa serum_phospholipids 0.102 0.222 dn no no no no no Calcium signaling pathway d18:1-22:1-SM+blood 0 0.502941176 0 kegg serum_phospholipids NA 0.222 no up up no no no Chemical carcinogenesis - receptor activation d18:1-22:1-SM+blood 0 0.635294118 0 kegg serum_phospholipids NA 0.222 no no no no no no Collinsella d18:1-22:1-SM+blood 0 -0.537618109 0 Genus serum_phospholipids 0.128 0.222 no no no no no no Creatinine+blood d18:1-22:1-SM+blood 0 0 -0.488547009 serum_choline serum_phospholipids 0.437 0.222 no no no no no no Cushing syndrome d18:1-22:1-SM+blood 0 0.520588235 0 kegg serum_phospholipids NA 0.222 no no up no no no d18:0-16:0-SM+blood d18:1-22:1-SM+blood 0.852631579 0.803921569 0.728547009 serum_phospholipids serum_phospholipids 0.202 0.222 no no no no no no d18:0-18:3-SM+blood d18:1-22:1-SM+blood 0.751879699 0.512254902 0.586324786 serum_phospholipids serum_phospholipids 0.0879 0.222 no dn no no no no d18:0-24:1-SM+blood d18:1-22:1-SM+blood 0.654135338 0.580882353 0.56991453 serum_phospholipids serum_phospholipids 0.0609 0.222 no dn dn no no no d18:1-14:0-SM+blood d18:1-22:1-SM+blood 0 0.517156863 0.61982906 serum_phospholipids serum_phospholipids 0.94 0.222 no no no no no no d18:1-14:1-SM+blood d18:1-22:1-SM+blood 0 0.644607843 0.602051282 serum_phospholipids serum_phospholipids 0.0952 0.222 no dn no no no no d18:1-16:0-SM+blood d18:1-22:1-SM+blood 0.857142857 0.786764706 0.71965812 serum_phospholipids serum_phospholipids 0.14 0.222 no no no no no no d18:1-16:1-SM+blood d18:1-22:1-SM+blood 0.836090226 0.806372549 0.734700855 serum_phospholipids serum_phospholipids 0.2 0.222 no no no no no no d18:1-18:1-SM+blood d18:1-22:1-SM+blood 0.556390977 0.49754902 0 serum_phospholipids serum_phospholipids 0.916 0.222 no no no no no no d18:1-20:0-SM+blood d18:1-22:1-SM+blood 0.781954887 0.87254902 0.74017094 serum_phospholipids serum_phospholipids 0.933 0.222 no no no no no no d18:1-20:1-SM+blood d18:1-22:1-SM+blood 0.627067669 0.705882353 0 serum_phospholipids serum_phospholipids 0.0992 0.222 no no no no no no d18:1-22:0-SM+blood d18:1-22:1-SM+blood 0.637593985 0.583333333 0.762735043 serum_phospholipids serum_phospholipids 0.522 0.222 no no no no no no Endocrine resistance d18:1-22:1-SM+blood 0 0.614705882 0 kegg serum_phospholipids NA 0.222 no no no no no no Epstein-Barr virus infection d18:1-22:1-SM+blood 0.464912281 -0.55 0 kegg serum_phospholipids NA 0.222 no no no no no no Gap junction d18:1-22:1-SM+blood 0 0 0.443846154 kegg serum_phospholipids NA 0.222 no no no no no no Gastric cancer d18:1-22:1-SM+blood -0.60877193 0.526470588 0 kegg serum_phospholipids NA 0.222 no no no no no no GDCA+stool d18:1-22:1-SM+blood 0.71978022 0 0 stool_bileacids serum_phospholipids 0.656 0.222 no no no no no no Glutathione metabolism d18:1-22:1-SM+blood 0 0 0.405384615 kegg serum_phospholipids NA 0.222 no no no no no no GnRH signaling pathway d18:1-22:1-SM+blood 0 0.514705882 0 kegg serum_phospholipids NA 0.222 no no no no no no Herpes simplex virus 1 infection d18:1-22:1-SM+blood 0.494736842 -0.591176471 0 kegg serum_phospholipids NA 0.222 no no no no no no HIF-1 signaling pathway d18:1-22:1-SM+blood -0.521052632 0 0 kegg serum_phospholipids NA 0.222 no no no no no no Human cytomegalovirus infection d18:1-22:1-SM+blood 0.489473684 0 0 kegg serum_phospholipids NA 0.222 no no dn no no no Human immunodeficiency virus 1 infection d18:1-22:1-SM+blood 0.459649123 -0.511764706 0 kegg serum_phospholipids NA 0.222 no no no no no no Human T-cell leukemia virus 1 infection d18:1-22:1-SM+blood 0.585964912 -0.561764706 0 kegg serum_phospholipids NA 0.222 no no no no no no Insulin signaling pathway d18:1-22:1-SM+blood -0.501754386 0 0 kegg serum_phospholipids NA 0.222 no no no no no no Long-term depression d18:1-22:1-SM+blood 0 0 0.437692308 kegg serum_phospholipids NA 0.222 no no no no no no Longevity regulating pathway d18:1-22:1-SM+blood -0.507017544 0 0 kegg serum_phospholipids NA 0.222 no no no no no no Mineral absorption d18:1-22:1-SM+blood -0.542105263 0 0 kegg serum_phospholipids NA 0.222 no no no no no no Mitophagy - animal d18:1-22:1-SM+blood -0.510526316 0 0 kegg serum_phospholipids NA 0.222 no no no no no no mTOR signaling pathway d18:1-22:1-SM+blood -0.480701754 0 0 kegg serum_phospholipids NA 0.222 no no no no no no Necroptosis d18:1-22:1-SM+blood -0.480701754 0 0 kegg serum_phospholipids NA 0.222 no no no no no no Neuroactive ligand-receptor interaction d18:1-22:1-SM+blood 0 0 -0.425384615 kegg serum_phospholipids NA 0.222 up up up no no no Pathogenic Escherichia coli infection d18:1-22:1-SM+blood 0.477192982 0 0 kegg serum_phospholipids NA 0.222 no no no no no no Phenylacetic acid+stool d18:1-22:1-SM+blood 0 0.609090909 0 stool_cometabolism serum_phospholipids 0.785 0.222 no no no no no no Propionic acid+stool d18:1-22:1-SM+blood -0.653846154 0 0 yes stool_scfa serum_phospholipids 0.0436 0.222 dn no up no no no Proteasome d18:1-22:1-SM+blood 0 0 -0.463076923 kegg serum_phospholipids NA 0.222 no no no no no no Ruminococcus d18:1-22:1-SM+blood 0 -0.570202437 0 Genus serum_phospholipids 0.0679 0.222 no no dn no no no Signaling pathways regulating pluripotency of stem cells d18:1-22:1-SM+blood 0 0.561764706 0 kegg serum_phospholipids NA 0.222 no no no no no no Thyroid hormone synthesis d18:1-22:1-SM+blood 0 0 0.533846154 kegg serum_phospholipids NA 0.222 no no no no no no total_stool_scfa+stool d18:1-22:1-SM+blood -0.692307692 0 0 stool_scfa serum_phospholipids 0.0534 0.222 dn no up no no no Ubiquitin mediated proteolysis d18:1-22:1-SM+blood -0.477192982 0 0 kegg serum_phospholipids NA 0.222 no no no no no no 12-ketoDCA+blood d18:1-24:1-SM+blood 0 0.559840896 0 serum_bileacids serum_phospholipids 0.517 0.0123 no no no no dn dn "12,13-EPOME+blood" d18:1-24:1-SM+blood 0 -0.586239742 0 serum_ARA serum_phospholipids 0.901 0.0123 no no no no dn dn 14:0+blood d18:1-24:1-SM+blood 0 -0.573529412 0 yes serum_fattyacid serum_phospholipids 0.00572 0.0123 up no dn no dn dn 16:0/18:2-PC+blood d18:1-24:1-SM+blood 0 0 -0.435897436 serum_phospholipids serum_phospholipids 3.24E-06 0.0123 no up up no dn dn 16:0/20:5-PG+blood d18:1-24:1-SM+blood 0.520300752 0 0 serum_phospholipids serum_phospholipids 0.00656 0.0123 no up no no dn dn 16:1/16:0-PC+blood d18:1-24:1-SM+blood 0 0 -0.469401709 serum_phospholipids serum_phospholipids 0.0215 0.0123 no up up no dn dn 16:1/16:1-PC+blood d18:1-24:1-SM+blood 0 0 -0.522735043 serum_phospholipids serum_phospholipids 0.0177 0.0123 no no up no dn dn 18:0/18:0-PE+blood d18:1-24:1-SM+blood 0 -0.62254902 0 serum_phospholipids serum_phospholipids 0.00896 0.0123 up up no no dn dn 18:0/18:1-PC+blood d18:1-24:1-SM+blood 0 0 0.405128205 serum_phospholipids serum_phospholipids 0.393 0.0123 no no no no dn dn 18:0/18:1-PE+blood d18:1-24:1-SM+blood 0 -0.526960784 0 serum_phospholipids serum_phospholipids 0.00716 0.0123 up up no no dn dn 18:0/20:2-PC+blood d18:1-24:1-SM+blood 0 0.549019608 0.645811966 serum_phospholipids serum_phospholipids 0.733 0.0123 no no no no dn dn 18:1-LPC+blood d18:1-24:1-SM+blood 0 0 0.433162393 serum_phospholipids serum_phospholipids 0.179 0.0123 no no no no dn dn 18:1/16:0-PC+blood d18:1-24:1-SM+blood 0 0 -0.414017094 serum_phospholipids serum_phospholipids 2.43E-05 0.0123 no up up no dn dn 18:1/16:0-PE+blood d18:1-24:1-SM+blood 0 -0.558823529 0 serum_phospholipids serum_phospholipids 0.000182 0.0123 up up no no dn dn 18:1/18:0-PE+blood d18:1-24:1-SM+blood 0 -0.56127451 0 serum_phospholipids serum_phospholipids 1.39E-06 0.0123 up up no no dn dn 18:1/18:1-PE+blood d18:1-24:1-SM+blood 0 -0.531862745 0 serum_phospholipids serum_phospholipids 1.03E-05 0.0123 up up no no dn dn 18:1/18:2-PE+blood d18:1-24:1-SM+blood 0 -0.49754902 0 serum_phospholipids serum_phospholipids 0.000293 0.0123 up up no no dn dn 18:1/20:4-PC+blood d18:1-24:1-SM+blood 0.445112782 0.539215686 0 serum_phospholipids serum_phospholipids 0.582 0.0123 no no no no dn dn 18:2-LPE+blood d18:1-24:1-SM+blood -0.47518797 0 0 serum_phospholipids serum_phospholipids 0.112 0.0123 no no no no dn dn 18:2n6c+blood d18:1-24:1-SM+blood 0 -0.549019608 0 serum_fattyacid serum_phospholipids 0.15 0.0123 no no no no dn dn 20:0-LPC+blood d18:1-24:1-SM+blood 0 0.490196078 0.446153846 serum_phospholipids serum_phospholipids 0.199 0.0123 no no no no dn dn 20:0/20:5-PC+blood d18:1-24:1-SM+blood 0 0.693627451 0 serum_phospholipids serum_phospholipids 0.882 0.0123 no no no no dn dn 20:3/18:0-PC+blood d18:1-24:1-SM+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.296 0.0123 no no no no dn dn 20:4n6+blood d18:1-24:1-SM+blood 0.538345865 0 0 serum_fattyacid serum_phospholipids 0.133 0.0123 no no no no dn dn "9,10-EPOME+blood" d18:1-24:1-SM+blood 0.450180917 0 0 serum_ARA serum_phospholipids 0.801 0.0123 no no no no dn dn Antigen processing and presentation d18:1-24:1-SM+blood 0 -0.55 0 kegg serum_phospholipids NA 0.0123 no no no no dn dn Arginine and proline metabolism d18:1-24:1-SM+blood 0.592982456 0 0 kegg serum_phospholipids NA 0.0123 no up no no dn dn Asthma d18:1-24:1-SM+blood 0 0 0.411538462 kegg serum_phospholipids NA 0.0123 no no no no dn dn Butyricimonas d18:1-24:1-SM+blood 0 0 -0.401833329 butyrate-producing Genus serum_phospholipids 0.17 0.0123 no no no no dn dn Clostridium d18:1-24:1-SM+blood -0.594960554 0 0.410637065 Genus serum_phospholipids 0.925 0.0123 no no no no dn dn Clostridium d18:1-24:1-SM+blood -0.594960554 0 -0.433603952 Genus serum_phospholipids 0.925 0.0123 no no no no dn dn Coprococcus d18:1-24:1-SM+blood 0.44962406 0 0 butyrate-producing Genus serum_phospholipids 0.612 0.0123 no no no no dn dn d18:0-16:0-SM+blood d18:1-24:1-SM+blood 0.509774436 0.585784314 0.476239316 serum_phospholipids serum_phospholipids 0.202 0.0123 no no no no dn dn d18:0-24:1-SM+blood d18:1-24:1-SM+blood 0.587969925 0.818627451 0.72034188 serum_phospholipids serum_phospholipids 0.0609 0.0123 no dn dn no dn dn d18:1-14:0-SM+blood d18:1-24:1-SM+blood 0 0 0.48034188 serum_phospholipids serum_phospholipids 0.94 0.0123 no no no no dn dn d18:1-14:1-SM+blood d18:1-24:1-SM+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 0.0952 0.0123 no dn no no dn dn d18:1-16:0-SM+blood d18:1-24:1-SM+blood 0.527819549 0.578431373 0.475555556 serum_phospholipids serum_phospholipids 0.14 0.0123 no no no no dn dn d18:1-16:1-SM+blood d18:1-24:1-SM+blood 0 0.571078431 0.461880342 serum_phospholipids serum_phospholipids 0.2 0.0123 no no no no dn dn d18:1-20:0-SM+blood d18:1-24:1-SM+blood 0 0.737745098 0 serum_phospholipids serum_phospholipids 0.933 0.0123 no no no no dn dn d18:1-20:1-SM+blood d18:1-24:1-SM+blood 0 0.580882353 0 serum_phospholipids serum_phospholipids 0.0992 0.0123 no no no no dn dn d18:1-22:0-SM+blood d18:1-24:1-SM+blood 0.681203008 0.899509804 0.87965812 serum_phospholipids serum_phospholipids 0.522 0.0123 no no no no dn dn d18:1-22:1-SM+blood d18:1-24:1-SM+blood 0 0.705882353 0.66974359 serum_phospholipids serum_phospholipids 0.222 0.0123 no no no no dn dn Epstein-Barr virus infection d18:1-24:1-SM+blood 0 -0.579411765 0 kegg serum_phospholipids NA 0.0123 no no no no dn dn Faecalibacterium d18:1-24:1-SM+blood 0 0 0.487604726 butyrate-producing Genus serum_phospholipids 0.0039 0.0123 no dn dn no dn dn GABAergic synapse d18:1-24:1-SM+blood 0 0 -0.416923077 kegg serum_phospholipids NA 0.0123 no up up no dn dn Hematopoietic cell lineage d18:1-24:1-SM+blood 0 0 0.447692308 kegg serum_phospholipids NA 0.0123 no no no no dn dn Herpes simplex virus 1 infection d18:1-24:1-SM+blood 0 -0.582352941 0 kegg serum_phospholipids NA 0.0123 no no no no dn dn Human cytomegalovirus infection d18:1-24:1-SM+blood 0 -0.535294118 0 kegg serum_phospholipids NA 0.0123 no no dn no dn dn Human immunodeficiency virus 1 infection d18:1-24:1-SM+blood 0 -0.555882353 0 kegg serum_phospholipids NA 0.0123 no no no no dn dn Human T-cell leukemia virus 1 infection d18:1-24:1-SM+blood 0 -0.591176471 0 kegg serum_phospholipids NA 0.0123 no no no no dn dn Inflammatory bowel disease d18:1-24:1-SM+blood 0 0 0.443076923 kegg serum_phospholipids NA 0.0123 no no no no dn dn Inflammatory mediator regulation of TRP channels d18:1-24:1-SM+blood -0.463157895 0 0 kegg serum_phospholipids NA 0.0123 no no no no dn dn Intestinal immune network for IgA production d18:1-24:1-SM+blood 0 0 0.439230769 kegg serum_phospholipids NA 0.0123 no no no no dn dn JAK-STAT signaling pathway d18:1-24:1-SM+blood 0.468421053 0 0 kegg serum_phospholipids NA 0.0123 no no no no dn dn Measles d18:1-24:1-SM+blood 0.538596491 0 0 kegg serum_phospholipids NA 0.0123 no no no no dn dn TCA+stool d18:1-24:1-SM+blood 0 -0.672727273 0 stool_bileacids serum_phospholipids 0.458 0.0123 no no no no dn dn TDCA+stool d18:1-24:1-SM+blood 0 -0.776954316 0 stool_bileacids serum_phospholipids 0.963 0.0123 no no no no dn dn 12-HEPE+blood DCA+blood 0.445082418 0 0 serum_ARA serum_bileacids 0.312 0.122 no no no no no no 12-ketoDCA+blood DCA+blood 0.619498108 0.602652259 0 serum_bileacids serum_bileacids 0.517 0.122 no no no no no no "12,13-EPOME+blood" DCA+blood 0 0 0.511601235 serum_ARA serum_bileacids 0.901 0.122 no no no no no no 16:0/16:1-PI+blood DCA+blood 0.466165414 0 0 serum_phospholipids serum_bileacids 0.262 0.122 no no no no no no 16:0/18:0-PC+blood DCA+blood -0.479699248 0 0 serum_phospholipids serum_bileacids 0.521 0.122 no no no no no no 16:0/18:0-PS+blood DCA+blood -0.460150376 -0.549019608 0 serum_phospholipids serum_bileacids 0.377 0.122 no no no no no no 16:0/20:4-PE+blood DCA+blood 0 -0.588235294 0 serum_phospholipids serum_bileacids 0.00139 0.122 up up no no no no 16:0/22:6-PE+blood DCA+blood -0.49924812 0 0 serum_phospholipids serum_bileacids 0.000934 0.122 up up no no no no 16:0+blood DCA+blood -0.44962406 -0.551470588 0 yes serum_fattyacid serum_bileacids 0.00876 0.122 up no no no no no 16:1/16:1-PC+blood DCA+blood -0.458646617 0 0 serum_phospholipids serum_bileacids 0.0177 0.122 no no up no no no 18:0-LPA+blood DCA+blood -0.455639098 0 0 serum_phospholipids serum_bileacids 0.0725 0.122 no dn no no no no 18:0-LPC+blood DCA+blood 0 0.674019608 0 serum_phospholipids serum_bileacids 0.554 0.122 no no no no no no 18:0/18:0-PS+blood DCA+blood -0.523308271 0 0 serum_phospholipids serum_bileacids 0.00617 0.122 no up no no no no 18:0/20:4-PC+blood DCA+blood 0 0 -0.427692308 serum_phospholipids serum_bileacids 0.454 0.122 no no no no no no 18:1/16:0-PE+blood DCA+blood 0 -0.482843137 0 serum_phospholipids serum_bileacids 0.000182 0.122 up up no no no no 18:1/18:0-PS+blood DCA+blood -0.44962406 0 0 serum_phospholipids serum_bileacids 0.193 0.122 no no no no no no 18:1/20:3-PC+blood DCA+blood 0 0.580882353 -0.401709402 serum_phospholipids serum_bileacids 0.00872 0.122 no up up no no no 18:1/20:4-PC+blood DCA+blood 0 0 -0.443418803 serum_phospholipids serum_bileacids 0.582 0.122 no no no no no no 18:1/20:4-PE+blood DCA+blood -0.596992481 -0.512254902 0 serum_phospholipids serum_bileacids 0.0578 0.122 up no no no no no 18:1/20:4-PI+blood DCA+blood 0 0 -0.422905983 serum_phospholipids serum_bileacids 0.192 0.122 no no no no no no 18:3-LPC+blood DCA+blood 0 0 0.406495726 serum_phospholipids serum_bileacids 0.147 0.122 no no no no no no 18:3n3+blood DCA+blood -0.515789474 0 0 serum_fattyacid serum_bileacids 0.291 0.122 no no no no no no 20:0-LPC+blood DCA+blood 0 0.656862745 0 serum_phospholipids serum_bileacids 0.199 0.122 no no no no no no 20:0/20:4-PE+blood DCA+blood -0.463157895 0 0 serum_phospholipids serum_bileacids 0.00128 0.122 up up no no no no 20:0/20:5-PC+blood DCA+blood 0 0 -0.40034188 serum_phospholipids serum_bileacids 0.882 0.122 no no no no no no 20:1/20:4-PE+blood DCA+blood -0.509774436 0 0 serum_phospholipids serum_bileacids 0.0042 0.122 up up no no no no 20:2-LPC+blood DCA+blood 0 0.495098039 0 serum_phospholipids serum_bileacids 0.119 0.122 no no up no no no 20:2/18:3-PE+blood DCA+blood -0.469172932 0 -0.504273504 serum_phospholipids serum_bileacids 0.0391 0.122 up up no no no no 20:3/18:0-PC+blood DCA+blood -0.511278195 0 0 serum_phospholipids serum_bileacids 0.296 0.122 no no no no no no 20:4-LPA+blood DCA+blood -0.664661654 0 -0.442735043 serum_phospholipids serum_bileacids 0.398 0.122 no no no no no no 20:4/18:0-PE+blood DCA+blood -0.62406015 0 0 serum_phospholipids serum_bileacids 0.000755 0.122 up up no no no no 20:5n3+blood DCA+blood 0 0 0.437264957 serum_fattyacid serum_bileacids 0.988 0.122 no no no no no no 9-HODE+blood DCA+blood 0 0 0.413333333 serum_ARA serum_bileacids 0.297 0.122 no no no no no no AA+blood DCA+blood -0.485714286 0 0 serum_ARA serum_bileacids 0.212 0.122 no no no no no no Adrenergic signaling in cardiomyocytes DCA+blood 0 0.514705882 0 kegg serum_bileacids NA 0.122 no no up no no no AGE-RAGE signaling pathway in diabetic complications DCA+blood 0 -0.517647059 0 kegg serum_bileacids NA 0.122 no no no no no no Alcoholism DCA+blood 0.471929825 0 0 kegg serum_bileacids NA 0.122 no no no no no no Aldosterone synthesis and secretion DCA+blood 0 0.644117647 0.413846154 kegg serum_bileacids NA 0.122 no up up no no no Alzheimer disease DCA+blood 0 0.532352941 0 kegg serum_bileacids NA 0.122 no no no no no no Apelin signaling pathway DCA+blood 0 0.520588235 0 kegg serum_bileacids NA 0.122 no no no no no no Bifidobacterium DCA+blood -0.448288862 0 0 acetate-producing Genus serum_bileacids 0.105 0.122 no dn no no no no Biosynthesis of amino acids DCA+blood 0 0 -0.513846154 kegg serum_bileacids NA 0.122 no no no no no no butyric acid C4+blood DCA+blood -0.469172932 0 0 serum_scfa serum_bileacids 0.407 0.122 no no no no no no Butyric acid+stool DCA+blood 0 0.618181818 0 yes stool_scfa serum_bileacids 0.102 0.122 dn no no no no no CA+blood DCA+blood 0 0 0.621959063 serum_bileacids serum_bileacids 0.606 0.122 no no no no no no Calcium signaling pathway DCA+blood 0 0.776470588 0.430769231 kegg serum_bileacids NA 0.122 no up up no no no capric acid C6+blood DCA+blood 0 0 -0.414017094 serum_scfa serum_bileacids 0.433 0.122 no no no no no no Carbon metabolism DCA+blood 0 0 -0.557692308 kegg serum_bileacids NA 0.122 no no no no no no Cardiac muscle contraction DCA+blood 0 0.585294118 0 kegg serum_bileacids NA 0.122 no no up no no no CDCA+blood DCA+blood 0.52481203 0 0.681367521 serum_bileacids serum_bileacids 0.506 0.122 no no no no no no cGMP-PKG signaling pathway DCA+blood 0 0 -0.438461538 kegg serum_bileacids NA 0.122 no no no no no no Coronavirus disease - COVID-19 DCA+blood 0 0.585294118 0 kegg serum_bileacids NA 0.122 no no no no no no Cushing syndrome DCA+blood 0 0 0.407692308 kegg serum_bileacids NA 0.122 no no up no no no Cystine+blood DCA+blood 0 0 -0.493333333 yes serum_aminoacids serum_bileacids 0.00028 0.122 up up no no no no d18:0-24:1-SM+blood DCA+blood 0 0.578431373 0 serum_phospholipids serum_bileacids 0.0609 0.122 no dn dn no no no d18:1-22:0-SM+blood DCA+blood 0 0.553921569 0 serum_phospholipids serum_bileacids 0.522 0.122 no no no no no no d18:1-22:1-SM+blood DCA+blood 0 0.509803922 0 serum_phospholipids serum_bileacids 0.222 0.122 no no no no no no d18:1-24:1-SM+blood DCA+blood 0 0.56372549 0 serum_phospholipids serum_bileacids 0.0123 0.122 no dn dn no no no Diabetic cardiomyopathy DCA+blood 0 0.55 0 kegg serum_bileacids NA 0.122 no no no no no no EGFR tyrosine kinase inhibitor resistance DCA+blood 0 0.564705882 0 kegg serum_bileacids NA 0.122 no no no no no no Fc gamma R-mediated phagocytosis DCA+blood 0 0 -0.456153846 kegg serum_bileacids NA 0.122 no no no no no no GABAergic synapse DCA+blood 0 0 -0.437692308 kegg serum_bileacids NA 0.122 no up up no no no Glucagon signaling pathway DCA+blood 0 0.558823529 0 kegg serum_bileacids NA 0.122 no no no no no no Glutathione metabolism DCA+blood 0.466666667 0 0 kegg serum_bileacids NA 0.122 no no no no no no Huntington disease DCA+blood 0 0.535294118 0 kegg serum_bileacids NA 0.122 no no no no no no Inflammatory mediator regulation of TRP channels DCA+blood 0 0.541176471 0 kegg serum_bileacids NA 0.122 no no no no no no Insulin signaling pathway DCA+blood 0 0.523529412 0 kegg serum_bileacids NA 0.122 no no no no no no L-Phenylalanine+stool DCA+blood -0.664835165 0 0 stool_cometabolism serum_bileacids 0.398 0.122 no no no no no no L-Tryptophan+stool DCA+blood -0.71978022 0 0 stool_cometabolism serum_bileacids 0.557 0.122 no no no no no no L-Tyrosine+stool DCA+blood -0.664835165 0 0 stool_cometabolism serum_bileacids 0.44 0.122 no no no no no no Lysosome DCA+blood 0 0 -0.411538462 kegg serum_bileacids NA 0.122 no no no no no no Melanogenesis DCA+blood 0 0.65 0 kegg serum_bileacids NA 0.122 no no no no no no Mitophagy - animal DCA+blood 0.473684211 0.623529412 0 kegg serum_bileacids NA 0.122 no no no no no no Morphine addiction DCA+blood 0 0.505882353 0 kegg serum_bileacids NA 0.122 no up up no no no mTOR signaling pathway DCA+blood 0 0.555882353 0 kegg serum_bileacids NA 0.122 no no no no no no Neuroactive ligand-receptor interaction DCA+blood 0 -0.552941176 -0.406923077 kegg serum_bileacids NA 0.122 up up up no no no Neutrophil extracellular trap formation DCA+blood 0 -0.511764706 0 kegg serum_bileacids NA 0.122 no no no no no no Nicotinate and nicotinamide metabolism DCA+blood 0 -0.55 0 kegg serum_bileacids NA 0.122 no no no no no no Oxidative phosphorylation DCA+blood 0 0.535294118 0 kegg serum_bileacids NA 0.122 no no no no no no Pancreatic secretion DCA+blood 0 0.555882353 0 kegg serum_bileacids NA 0.122 no no no no no no "Parathyroid hormone synthesis, secretion and action" DCA+blood 0 0.617647059 0 kegg serum_bileacids NA 0.122 no no no no no no Parkinson disease DCA+blood 0 0.514705882 0 kegg serum_bileacids NA 0.122 no no no no no no Pathways in cancer DCA+blood 0 0 0.429230769 kegg serum_bileacids NA 0.122 no no no no no no Pathways of neurodegeneration - multiple diseases DCA+blood 0 0.523529412 0 kegg serum_bileacids NA 0.122 no no no no no no Peroxisome DCA+blood 0 -0.508823529 0 kegg serum_bileacids NA 0.122 no no no no no no Pertussis DCA+blood 0 -0.511764706 0 kegg serum_bileacids NA 0.122 no no dn no no no PPAR signaling pathway DCA+blood 0 0 -0.546153846 kegg serum_bileacids NA 0.122 no no no no no no Purine metabolism DCA+blood 0 0.632352941 0 kegg serum_bileacids NA 0.122 no no no no no no Rheumatoid arthritis DCA+blood 0 -0.558823529 0 kegg serum_bileacids NA 0.122 no no no no no no Ribosome DCA+blood 0 0.585294118 0 kegg serum_bileacids NA 0.122 no no no no no no RNA transport DCA+blood 0 0.570588235 0 kegg serum_bileacids NA 0.122 no no no no no no Shigellosis DCA+blood 0.538596491 0 0 kegg serum_bileacids NA 0.122 no no no no no no Slackia DCA+blood 0 0 0.49534449 Genus serum_bileacids 0.94 0.122 no no no no no no Staphylococcus aureus infection DCA+blood 0 -0.567647059 -0.479230769 kegg serum_bileacids NA 0.122 up no no no no no Systemic lupus erythematosus DCA+blood 0 -0.614705882 -0.48 kegg serum_bileacids NA 0.122 no no no no no no Thermogenesis DCA+blood 0 0.526470588 0 kegg serum_bileacids NA 0.122 no no no no no no Thyroid hormone synthesis DCA+blood 0 0.535294118 0 kegg serum_bileacids NA 0.122 no no no no no no Tuberculosis DCA+blood 0 -0.626470588 -0.49 kegg serum_bileacids NA 0.122 no no dn no no no Ubiquitin mediated proteolysis DCA+blood 0 0.608823529 0 kegg serum_bileacids NA 0.122 no no no no no no 12-ketoDCA+stool DCA+stool 0.554179567 0.654992248 0.42687747 stool_bileacids stool_bileacids 0.505 0.195 no no no no no no 4-hydroxybenzoic acid+stool DCA+stool 0 -0.65034965 0 stool_cometabolism stool_bileacids 0.0536 0.195 no dn no no no no AGE-RAGE signaling pathway in diabetic complications DCA+stool 0 0 0.547148504 kegg stool_bileacids NA 0.195 no no no no no no Antigen processing and presentation DCA+stool 0 -0.754545455 0 kegg stool_bileacids NA 0.195 no no no no no no Apoptosis DCA+stool -0.783281734 0 0 kegg stool_bileacids NA 0.195 no no no no no no Breast cancer DCA+stool 0 0 0.436476567 kegg stool_bileacids NA 0.195 no no no no no no Butyricicoccus DCA+stool 0 0 0.436859765 butyrate-producing Genus stool_bileacids 0.852 0.195 no no no no no no CA+stool DCA+stool -0.517027864 0 0 stool_bileacids stool_bileacids 0.827 0.195 no no no no no no Carbon metabolism DCA+stool 0 -0.745454545 0 kegg stool_bileacids NA 0.195 no no no no no no CDCA+stool DCA+stool -0.587203302 0 0 stool_bileacids stool_bileacids 0.663 0.195 no no no no no no Chemical carcinogenesis - receptor activation DCA+stool 0 0.718181818 0 kegg stool_bileacids NA 0.195 no no no no no no Choline metabolism in cancer DCA+stool 0 0.681818182 0 kegg stool_bileacids NA 0.195 no no no no no no Clostridium DCA+stool 0 -0.653157881 0 Genus stool_bileacids 0.925 0.195 no no no no no no Cocaine addiction DCA+stool 0 0.663636364 0 kegg stool_bileacids NA 0.195 no no no no no no Coprococcus DCA+stool 0 0 0.572134387 butyrate-producing Genus stool_bileacids 0.612 0.195 no no no no no no Coronavirus disease - COVID-19 DCA+stool 0.533539732 0 0 kegg stool_bileacids NA 0.195 no no no no no no Cortisol synthesis and secretion DCA+stool 0 0.7 0 kegg stool_bileacids NA 0.195 no no up no no no Cushing syndrome DCA+stool 0 0.763636364 0 kegg stool_bileacids NA 0.195 no no up no no no Endocrine resistance DCA+stool 0 0.736363636 0 kegg stool_bileacids NA 0.195 no no no no no no Endocytosis DCA+stool -0.512899897 0 0 kegg stool_bileacids NA 0.195 no no no no no no Epithelial cell signaling in Helicobacter pylori infection DCA+stool -0.533539732 0 0 kegg stool_bileacids NA 0.195 no no no no no no Epstein-Barr virus infection DCA+stool 0 -0.672727273 0 kegg stool_bileacids NA 0.195 no no no no no no Fc gamma R-mediated phagocytosis DCA+stool -0.475748194 -0.690909091 0 kegg stool_bileacids NA 0.195 no no no no no no Fluid shear stress and atherosclerosis DCA+stool 0 -0.690909091 0 kegg stool_bileacids NA 0.195 no no no no no no FoxO signaling pathway DCA+stool 0 0 0.470355731 kegg stool_bileacids NA 0.195 no no no no no no Fusobacterium DCA+stool 0 0 -0.527345237 Genus stool_bileacids 0.628 0.195 no no no no no no Gastric cancer DCA+stool 0 0.736363636 0.425183512 kegg stool_bileacids NA 0.195 no no no no no no Gemmiger DCA+stool 0.619514796 0 0 butyrate-producing Genus stool_bileacids 0.595 0.195 no no no no no no GnRH signaling pathway DCA+stool 0 0.718181818 0 kegg stool_bileacids NA 0.195 no no no no no no "Growth hormone synthesis, secretion and action" DCA+stool 0 0.645454545 0 kegg stool_bileacids NA 0.195 no no no no no no Herpes simplex virus 1 infection DCA+stool 0 -0.672727273 0 kegg stool_bileacids NA 0.195 no no no no no no Human cytomegalovirus infection DCA+stool 0 -0.718181818 0 kegg stool_bileacids NA 0.195 no no dn no no no Human immunodeficiency virus 1 infection DCA+stool 0 -0.672727273 0 kegg stool_bileacids NA 0.195 no no no no no no Human papillomavirus infection DCA+stool -0.504643963 0 0 kegg stool_bileacids NA 0.195 no no no no no no Human T-cell leukemia virus 1 infection DCA+stool 0 -0.718181818 0 kegg stool_bileacids NA 0.195 no no no no no no Insulin secretion DCA+stool 0 0.681818182 0 yes kegg stool_bileacids NA 0.195 no up up no no no JAK-STAT signaling pathway DCA+stool 0 0 0.451157538 kegg stool_bileacids NA 0.195 no no no no no no Leishmaniasis DCA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.195 no no no no no no Leukocyte transendothelial migration DCA+stool 0 -0.727272727 0 kegg stool_bileacids NA 0.195 no no no no no no Lysosome DCA+stool -0.479876161 0 0 kegg stool_bileacids NA 0.195 no no no no no no Morphine addiction DCA+stool 0 0.727272727 0 kegg stool_bileacids NA 0.195 no up up no no no Natural killer cell mediated cytotoxicity DCA+stool -0.50877193 0 0 kegg stool_bileacids NA 0.195 no no no no no no Neuroactive ligand-receptor interaction DCA+stool 0 -0.727272727 0 kegg stool_bileacids NA 0.195 up up up no no no Neutrophil extracellular trap formation DCA+stool -0.698658411 -0.636363636 0 kegg stool_bileacids NA 0.195 no no no no no no NOD-like receptor signaling pathway DCA+stool 0 0 0.549407115 kegg stool_bileacids NA 0.195 no no no no no no Odoribacter DCA+stool 0 -0.832167832 0 butyrate-producing Genus stool_bileacids 0.798 0.195 no no no no no no Oscillospira DCA+stool 0.663570691 0 0 LPS-producing Genus stool_bileacids 0.62 0.195 no no no no no no Osteoclast differentiation DCA+stool -0.539731682 0 0 kegg stool_bileacids NA 0.195 no no no no no no p53 signaling pathway DCA+stool 0 0.781818182 0 kegg stool_bileacids NA 0.195 no no no no no no Pancreatic cancer DCA+stool 0 0 0.596837945 kegg stool_bileacids NA 0.195 no no no no no no Pathogenic Escherichia coli infection DCA+stool -0.620227038 -0.809090909 0 kegg stool_bileacids NA 0.195 no no no no no no Pathways in cancer DCA+stool 0 0.690909091 0 kegg stool_bileacids NA 0.195 no no no no no no Phagosome DCA+stool -0.537667699 -0.654545455 0 kegg stool_bileacids NA 0.195 no no no no no no Platinum drug resistance DCA+stool 0 0.645454545 0 kegg stool_bileacids NA 0.195 no no no no no no Prolactin signaling pathway DCA+stool 0 0 0.504234896 kegg stool_bileacids NA 0.195 no no no no no no Regulation of actin cytoskeleton DCA+stool 0 -0.609090909 0 kegg stool_bileacids NA 0.195 no no no no no no Ribosome DCA+stool 0.539731682 0 0 kegg stool_bileacids NA 0.195 no no no no no no Salmonella infection DCA+stool -0.473684211 -0.809090909 0 kegg stool_bileacids NA 0.195 no no no no no no Signaling pathways regulating pluripotency of stem cells DCA+stool 0 0.672727273 0.466967815 kegg stool_bileacids NA 0.195 no no no no no no Staphylococcus aureus infection DCA+stool 0 -0.645454545 0 kegg stool_bileacids NA 0.195 up no no no no no Tight junction DCA+stool 0 -0.672727273 0 kegg stool_bileacids NA 0.195 no no no no no no Tuberculosis DCA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.195 no no dn no no no Viral carcinogenesis DCA+stool -0.562435501 0 0 kegg stool_bileacids NA 0.195 no no no no no no Yersinia infection DCA+stool -0.611971104 0 0 kegg stool_bileacids NA 0.195 no no no no no no 11-HETE+blood decanoic acid C10+blood 0 0.493276281 0 serum_ARA serum_mcfa 0.464 6.64E-11 no no no dn dn no 14:0/18:0-PC+blood decanoic acid C10+blood 0 0.703431373 0 serum_phospholipids serum_mcfa 0.00289 6.64E-11 up up no dn dn no 16:0/16:1-PC+blood decanoic acid C10+blood 0 0.678921569 0 serum_phospholipids serum_mcfa 0.00283 6.64E-11 up up no dn dn no 16:0/18:1-PE+blood decanoic acid C10+blood -0.45112782 0.541666667 0 serum_phospholipids serum_mcfa 0.000107 6.64E-11 up up no dn dn no 16:0/18:3-PC+blood decanoic acid C10+blood -0.556390977 0 0 serum_phospholipids serum_mcfa 0.00216 6.64E-11 no up up dn dn no 16:0/20:3-PC+blood decanoic acid C10+blood 0 0.602941176 0 serum_phospholipids serum_mcfa 5.43E-06 6.64E-11 no up up dn dn no 16:0/20:5-PC+blood decanoic acid C10+blood 0 -0.713235294 0 serum_phospholipids serum_mcfa 0.628 6.64E-11 no no no dn dn no 16:0/22:0-PE+blood decanoic acid C10+blood 0 -0.607843137 0 serum_phospholipids serum_mcfa 0.00839 6.64E-11 dn no up dn dn no 16:0/22:6-PC+blood decanoic acid C10+blood 0 -0.617647059 0 serum_phospholipids serum_mcfa 4.53E-05 6.64E-11 no up up dn dn no 16:1/18:1-PG+blood decanoic acid C10+blood 0 0.482843137 0 serum_phospholipids serum_mcfa 3.21E-05 6.64E-11 no up up dn dn no 18:0/18:1-PI+blood decanoic acid C10+blood 0 0.666666667 0 serum_phospholipids serum_mcfa 0.599 6.64E-11 no no no dn dn no 18:0/20:3-PC+blood decanoic acid C10+blood 0 0.485294118 0 serum_phospholipids serum_mcfa 0.0682 6.64E-11 no up no dn dn no 18:0/20:3-PI+blood decanoic acid C10+blood 0 0.683823529 0 serum_phospholipids serum_mcfa 0.377 6.64E-11 no no no dn dn no 18:0/20:4-PC+blood decanoic acid C10+blood 0 -0.62745098 0 serum_phospholipids serum_mcfa 0.454 6.64E-11 no no no dn dn no 18:0/20:5-PC+blood decanoic acid C10+blood 0 -0.762254902 0 serum_phospholipids serum_mcfa 0.17 6.64E-11 no no no dn dn no 18:0/22:6-PC+blood decanoic acid C10+blood 0 -0.629901961 0 serum_phospholipids serum_mcfa 0.0775 6.64E-11 no no up dn dn no 18:1-LPC+blood decanoic acid C10+blood 0.452631579 0 0 serum_phospholipids serum_mcfa 0.179 6.64E-11 no no no dn dn no 18:1-LPE+blood decanoic acid C10+blood 0 0.519607843 0 serum_phospholipids serum_mcfa 0.117 6.64E-11 no no no dn dn no 18:1/16:0-PE+blood decanoic acid C10+blood -0.512781955 0 0 serum_phospholipids serum_mcfa 0.000182 6.64E-11 up up no dn dn no 18:1/16:0-PI+blood decanoic acid C10+blood 0 0.593137255 0 serum_phospholipids serum_mcfa 0.793 6.64E-11 no no no dn dn no 18:1/16:1-PE+blood decanoic acid C10+blood -0.479699248 0.507352941 0 serum_phospholipids serum_mcfa 0.000184 6.64E-11 up up no dn dn no 18:1/18:0-PE+blood decanoic acid C10+blood 0 0.5 0 serum_phospholipids serum_mcfa 1.39E-06 6.64E-11 up up no dn dn no 18:1/18:1-PC+blood decanoic acid C10+blood 0 0.737745098 0 serum_phospholipids serum_mcfa 1.34E-05 6.64E-11 no up up dn dn no 18:1/18:1-PE+blood decanoic acid C10+blood -0.448120301 0 0 serum_phospholipids serum_mcfa 1.03E-05 6.64E-11 up up no dn dn no 18:1/18:1-PI+blood decanoic acid C10+blood 0.523308271 0 0 serum_phospholipids serum_mcfa 0.111 6.64E-11 dn no no dn dn no 18:1/18:2-PE+blood decanoic acid C10+blood 0 0.487745098 0 serum_phospholipids serum_mcfa 0.000293 6.64E-11 up up no dn dn no 18:1/20:3-PC+blood decanoic acid C10+blood 0 0.610294118 0 serum_phospholipids serum_mcfa 0.00872 6.64E-11 no up up dn dn no 18:1/20:4-PC+blood decanoic acid C10+blood 0 -0.62745098 0 serum_phospholipids serum_mcfa 0.582 6.64E-11 no no no dn dn no 18:1/20:4-PE+blood decanoic acid C10+blood -0.446616541 0 0 serum_phospholipids serum_mcfa 0.0578 6.64E-11 up no no dn dn no 18:2-LPC+blood decanoic acid C10+blood 0.557894737 0 0 serum_phospholipids serum_mcfa 0.00743 6.64E-11 dn no up dn dn no 18:2-LPE+blood decanoic acid C10+blood 0 0.644607843 0 serum_phospholipids serum_mcfa 0.112 6.64E-11 no no no dn dn no 18:2/18:2-PS+blood decanoic acid C10+blood 0 0.669117647 0 serum_phospholipids serum_mcfa 0.00674 6.64E-11 up up no dn dn no 18:3/16:0-PE+blood decanoic acid C10+blood -0.751879699 0 -0.447521368 serum_phospholipids serum_mcfa 0.00149 6.64E-11 up up no dn dn no 18:3n6+blood decanoic acid C10+blood 0 0 -0.526837607 serum_fattyacid serum_mcfa 0.0463 6.64E-11 up no dn dn dn no 2-methyl-butyric acid m-C4+blood decanoic acid C10+blood 0.592481203 0 0 serum_scfa serum_mcfa 0.262 6.64E-11 no no no dn dn no 20:0/20:5-PC+blood decanoic acid C10+blood 0 -0.56372549 0 serum_phospholipids serum_mcfa 0.882 6.64E-11 no no no dn dn no 20:2/18:1-PE+blood decanoic acid C10+blood -0.452631579 0 0 serum_phospholipids serum_mcfa 0.00208 6.64E-11 up up no dn dn no 20:2+blood decanoic acid C10+blood 0 0.612745098 0 serum_fattyacid serum_mcfa 0.478 6.64E-11 no no no dn dn no 20:3-LPC+blood decanoic acid C10+blood 0 0.676470588 0 serum_phospholipids serum_mcfa 0.0292 6.64E-11 no up no dn dn no 20:3-LPE+blood decanoic acid C10+blood 0 0.647058824 0 serum_phospholipids serum_mcfa 0.084 6.64E-11 no up no dn dn no 20:3n6+blood decanoic acid C10+blood 0 0.767156863 0 serum_fattyacid serum_mcfa 0.0884 6.64E-11 up no no dn dn no 20:4-LPC+blood decanoic acid C10+blood 0 -0.671568627 0 serum_phospholipids serum_mcfa 0.949 6.64E-11 no no no dn dn no 20:4n6+blood decanoic acid C10+blood 0 -0.568627451 0 serum_fattyacid serum_mcfa 0.133 6.64E-11 no no no dn dn no 20:5-LPC+blood decanoic acid C10+blood 0 -0.838235294 0 serum_phospholipids serum_mcfa 0.558 6.64E-11 no no no dn dn no 20:5n3+blood decanoic acid C10+blood 0 -0.671568627 0 serum_fattyacid serum_mcfa 0.988 6.64E-11 no no no dn dn no 22:6-LPC+blood decanoic acid C10+blood 0 -0.725490196 0 serum_phospholipids serum_mcfa 0.127 6.64E-11 no no up dn dn no 22:6n3+blood decanoic acid C10+blood 0 -0.585784314 0 serum_fattyacid serum_mcfa 0.792 6.64E-11 no no no dn dn no 9-HODE+blood decanoic acid C10+blood 0 0 -0.513846154 serum_ARA serum_mcfa 0.297 6.64E-11 no no no dn dn no AA+blood decanoic acid C10+blood 0 0 -0.421538462 serum_ARA serum_mcfa 0.212 6.64E-11 no no no dn dn no ACA+blood decanoic acid C10+blood 0 -0.48659424 0 serum_bileacids serum_mcfa 0.338 6.64E-11 no no no dn dn no capric acid C6+blood decanoic acid C10+blood 0 0 0.621880342 serum_scfa serum_mcfa 0.433 6.64E-11 no no no dn dn no Creatinine+blood decanoic acid C10+blood 0.503759398 0 0 serum_choline serum_mcfa 0.437 6.64E-11 no no no dn dn no d18:1-18:0-SM+blood decanoic acid C10+blood 0 -0.588235294 0 serum_phospholipids serum_mcfa 0.97 6.64E-11 no no no dn dn no d18:1-20:0-SM+blood decanoic acid C10+blood -0.455639098 -0.490196078 0 serum_phospholipids serum_mcfa 0.933 6.64E-11 no no no dn dn no d18:1-20:1-SM+blood decanoic acid C10+blood 0 -0.487745098 0 serum_phospholipids serum_mcfa 0.0992 6.64E-11 no no no dn dn no Bilophila Desulfovibrio 0 0.462200405 0 Genus Genus 0.528 0.27 no no no no no no Turicibacter Desulfovibrio 0 0.404179525 0 Genus Genus 0.269 0.27 no no no no no no 12-HEPE+blood DHA+blood -0.488623089 0 0 serum_ARA serum_ARA 0.312 0.872 no no no no no no 14:0/18:2-PC+blood DHA+blood 0.577443609 0 0 serum_phospholipids serum_ARA 0.102 0.872 no up no no no no 14:0+blood DHA+blood 0.565413534 0 0 yes serum_fattyacid serum_ARA 0.00572 0.872 up no dn no no no 16:0/16:1-PC+blood DHA+blood 0 -0.485294118 0 serum_phospholipids serum_ARA 0.00283 0.872 up up no no no no 16:0/16:1-PI+blood DHA+blood 0 -0.605392157 0 serum_phospholipids serum_ARA 0.262 0.872 no no no no no no 16:0/18:1-PE+blood DHA+blood 0 -0.541666667 0 serum_phospholipids serum_ARA 0.000107 0.872 up up no no no no 16:0/18:2-PI+blood DHA+blood 0 -0.703431373 0 serum_phospholipids serum_ARA 0.269 0.872 no no no no no no 16:0/20:4-PC+blood DHA+blood 0 0.669117647 0 serum_phospholipids serum_ARA 0.0262 0.872 no up no no no no 16:0/20:4-PI+blood DHA+blood 0 -0.602941176 0 serum_phospholipids serum_ARA 0.558 0.872 no no no no no no 16:0/22:6-PC+blood DHA+blood 0 0.5 0 serum_phospholipids serum_ARA 4.53E-05 0.872 no up up no no no 18:0-LPC+blood DHA+blood 0 -0.517156863 0 serum_phospholipids serum_ARA 0.554 0.872 no no no no no no 18:0/18:0-PC+blood DHA+blood 0 -0.490196078 0 serum_phospholipids serum_ARA 0.426 0.872 no no no no no no 18:0/18:1-PC+blood DHA+blood 0 -0.553921569 0 serum_phospholipids serum_ARA 0.393 0.872 no no no no no no 18:0/18:1-PE+blood DHA+blood 0 -0.578431373 0 serum_phospholipids serum_ARA 0.00716 0.872 up up no no no no 18:0/18:1-PG+blood DHA+blood 0 -0.522058824 0 serum_phospholipids serum_ARA 0.000842 0.872 no up no no no no 18:0/20:2-PC+blood DHA+blood 0 -0.504901961 0 serum_phospholipids serum_ARA 0.733 0.872 no no no no no no 18:0/20:3-PC+blood DHA+blood 0 -0.649509804 0 serum_phospholipids serum_ARA 0.0682 0.872 no up no no no no 18:0/20:4-PC+blood DHA+blood 0 0.492647059 0 serum_phospholipids serum_ARA 0.454 0.872 no no no no no no 18:0/20:5-PC+blood DHA+blood 0 0.5 0 serum_phospholipids serum_ARA 0.17 0.872 no no no no no no 18:0/22:6-PC+blood DHA+blood 0.521804511 0 0 serum_phospholipids serum_ARA 0.0775 0.872 no no up no no no 18:0/22:6-PI+blood DHA+blood 0.631578947 0 0 serum_phospholipids serum_ARA 0.425 0.872 no no no no no no 18:1/16:0-PE+blood DHA+blood 0 -0.566176471 0 serum_phospholipids serum_ARA 0.000182 0.872 up up no no no no 18:1/16:1-PE+blood DHA+blood 0 -0.583333333 0 serum_phospholipids serum_ARA 0.000184 0.872 up up no no no no 18:1/18:0-PE+blood DHA+blood 0 -0.642156863 0 serum_phospholipids serum_ARA 1.39E-06 0.872 up up no no no no 18:1/18:0-PI+blood DHA+blood 0 -0.568627451 0 serum_phospholipids serum_ARA 0.0931 0.872 no no up no no no 18:1/18:1-PE+blood DHA+blood 0 -0.669117647 0 serum_phospholipids serum_ARA 1.03E-05 0.872 up up no no no no 18:1/18:1-PG+blood DHA+blood 0 -0.56127451 0 serum_phospholipids serum_ARA 0.00352 0.872 no up up no no no 18:1/18:2-PE+blood DHA+blood 0 -0.678921569 0 serum_phospholipids serum_ARA 0.000293 0.872 up up no no no no 18:2/16:0-PC+blood DHA+blood 0 0.482843137 0 serum_phospholipids serum_ARA 8.67E-05 0.872 no up up no no no 18:3n3+blood DHA+blood 0.661654135 0.629901961 0 serum_fattyacid serum_ARA 0.291 0.872 no no no no no no 20:0-LPE+blood DHA+blood 0 -0.575980392 0 serum_phospholipids serum_ARA 0.0615 0.872 no no up no no no 20:0/20:4-PE+blood DHA+blood 0 -0.651960784 0 serum_phospholipids serum_ARA 0.00128 0.872 up up no no no no 20:1/20:4-PC+blood DHA+blood 0.559398496 0 0 serum_phospholipids serum_ARA 0.0419 0.872 no no up no no no 20:1/20:4-PE+blood DHA+blood 0 -0.575980392 0 serum_phospholipids serum_ARA 0.0042 0.872 up up no no no no 20:1+blood DHA+blood -0.497744361 0 0 yes serum_fattyacid serum_ARA 2.56E-05 0.872 dn dn dn no no no 20:2/18:0-PC+blood DHA+blood 0 -0.659313725 0 serum_phospholipids serum_ARA 0.0427 0.872 no up no no no no 20:2/18:1-PE+blood DHA+blood 0 -0.81372549 0 serum_phospholipids serum_ARA 0.00208 0.872 up up no no no no 20:3/16:0-PC+blood DHA+blood 0 0.656862745 0 serum_phospholipids serum_ARA 0.00405 0.872 no up up no no no 20:3n6+blood DHA+blood 0 -0.549019608 0 serum_fattyacid serum_ARA 0.0884 0.872 up no no no no no 20:4-LPC+blood DHA+blood 0 0.62254902 0 serum_phospholipids serum_ARA 0.949 0.872 no no no no no no 20:4-LPE+blood DHA+blood 0 0.482843137 0 serum_phospholipids serum_ARA 0.552 0.872 no no no no no no 20:4n6+blood DHA+blood 0 0.546568627 0 serum_fattyacid serum_ARA 0.133 0.872 no no no no no no 20:5-LPC+blood DHA+blood 0 0.5 0 serum_phospholipids serum_ARA 0.558 0.872 no no no no no no 20:5/18:0-PC+blood DHA+blood 0.569924812 0.495098039 0 serum_phospholipids serum_ARA 3.97E-06 0.872 no up up no no no 22:1-LPA+blood DHA+blood 0.487218045 0 0 serum_phospholipids serum_ARA 0.00373 0.872 no up up no no no 22:6-LPC+blood DHA+blood 0 0.539215686 0 serum_phospholipids serum_ARA 0.127 0.872 no no up no no no 3-(3-Hydroxyphenyl)propanoic acid+stool DHA+blood 0.582417582 0 0 stool_cometabolism serum_ARA 0.33 0.872 no no no no no no AA+blood DHA+blood 0.509774436 0.862745098 0 serum_ARA serum_ARA 0.212 0.872 no no no no no no Adipocytokine signaling pathway DHA+blood -0.784210526 0 0 kegg serum_ARA NA 0.872 no no no no no no Axon guidance DHA+blood 0 -0.614705882 0 kegg serum_ARA NA 0.872 no up up no no no Betaine+blood DHA+blood 0 0.629901961 0 serum_choline serum_ARA 0.857 0.872 no no no no no no Cellular senescence DHA+blood 0 0 0.455384615 kegg serum_ARA NA 0.872 no no no no no no Central carbon metabolism in cancer DHA+blood 0.550877193 0 0 kegg serum_ARA NA 0.872 no no no no no no Choline+blood DHA+blood -0.44962406 0 0 serum_choline serum_ARA 0.0395 0.872 no up no no no no Collinsella DHA+blood 0 0 -0.402158929 Genus serum_ARA 0.128 0.872 no no no no no no d18:1-14:1-SM+blood DHA+blood 0 -0.585784314 0 serum_phospholipids serum_ARA 0.0952 0.872 no dn no no no no Estrogen signaling pathway DHA+blood 0.496491228 0 0 kegg serum_ARA NA 0.872 no no no no no no GCA+stool DHA+blood 0 0 -0.521804511 stool_bileacids serum_ARA 0.0809 0.872 no no no no no no Gemmiger DHA+blood 0 0 0.401027985 butyrate-producing Genus serum_ARA 0.595 0.872 no no no no no no Human papillomavirus infection DHA+blood 0 0 0.518461538 kegg serum_ARA NA 0.872 no no no no no no Longevity regulating pathway - multiple species DHA+blood 0.489473684 0 0 kegg serum_ARA NA 0.872 no no no no no no Measles DHA+blood 0 0.532352941 0 kegg serum_ARA NA 0.872 no no no no no no Odoribacter DHA+blood 0 0 0.473307212 butyrate-producing Genus serum_ARA 0.798 0.872 no no no no no no Primary immunodeficiency DHA+blood 0.635087719 0 0 kegg serum_ARA NA 0.872 no no no no no no Th1 and Th2 cell differentiation DHA+blood -0.515789474 0.561764706 0 kegg serum_ARA NA 0.872 no no no no no no Th17 cell differentiation DHA+blood 0 0.555882353 0 kegg serum_ARA NA 0.872 no no no no no no Toxoplasmosis DHA+blood 0 0.529411765 0 kegg serum_ARA NA 0.872 no no no no no no Viral carcinogenesis DHA+blood 0 0 0.476153846 kegg serum_ARA NA 0.872 no no no no no no 2-Oxocarboxylic acid metabolism Diabetic cardiomyopathy -0.553913043 0 0 kegg kegg NA NA no no no no no no ABC transporters Diabetic cardiomyopathy -0.473043478 -0.436758893 0 kegg kegg NA NA no up up no no no Acute myeloid leukemia Diabetic cardiomyopathy 0 -0.502964427 0 kegg kegg NA NA no no no no no no Adherens junction Diabetic cardiomyopathy 0 0.679841897 0.636550837 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Diabetic cardiomyopathy 0.730434783 0.798418972 0 kegg kegg NA NA no no up no no no African trypanosomiasis Diabetic cardiomyopathy 0 -0.460474308 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Diabetic cardiomyopathy 0 -0.796442688 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Diabetic cardiomyopathy -0.506956522 -0.772727273 -0.516087516 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Diabetic cardiomyopathy 0.579130435 0.752964427 0 kegg kegg NA NA no up up no no no Allograft rejection Diabetic cardiomyopathy -0.431304348 0 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Diabetic cardiomyopathy -0.60173913 -0.763833992 0 kegg kegg NA NA no no no no no no Alzheimer disease Diabetic cardiomyopathy 0.979130435 0.994071146 0.953410553 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Diabetic cardiomyopathy -0.62173913 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Diabetic cardiomyopathy -0.634782609 0 0 kegg kegg NA NA no no no no no no Amoebiasis Diabetic cardiomyopathy 0 -0.54743083 0 kegg kegg NA NA no no no no no no Amphetamine addiction Diabetic cardiomyopathy 0.51826087 0.740118577 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Diabetic cardiomyopathy 0 0.416996047 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Diabetic cardiomyopathy 0.968695652 0.966403162 0.948519949 kegg kegg NA NA no no no no no no Apelin signaling pathway Diabetic cardiomyopathy 0 0.757905138 0 kegg kegg NA NA no no no no no no Apoptosis Diabetic cardiomyopathy -0.41826087 -0.563241107 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Diabetic cardiomyopathy 0 -0.476284585 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Diabetic cardiomyopathy 0 -0.779644269 -0.572972973 kegg kegg NA NA no up no no no no Arginine biosynthesis Diabetic cardiomyopathy -0.519130435 -0.719367589 -0.475160875 kegg kegg NA NA no no no no no no Arrhythmogenic right ventricular cardiomyopathy Diabetic cardiomyopathy 0 0.611660079 0.581981982 kegg kegg NA NA no up up no no no Autoimmune thyroid disease Diabetic cardiomyopathy -0.431304348 0 0 kegg kegg NA NA no no no no no no Autophagy - animal Diabetic cardiomyopathy 0 -0.716403162 -0.476705277 kegg kegg NA NA no no no no no no Axon guidance Diabetic cardiomyopathy 0.527826087 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Diabetic cardiomyopathy 0 -0.603754941 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Diabetic cardiomyopathy 0 0.425889328 0.456628057 kegg kegg NA NA no no no no no no Basal cell carcinoma Diabetic cardiomyopathy 0.43826087 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Diabetic cardiomyopathy -0.705217391 0 0 kegg kegg NA NA no no no no no no Bile secretion Diabetic cardiomyopathy 0.446956522 0.489130435 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Diabetic cardiomyopathy -0.762608696 -0.635375494 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Diabetic cardiomyopathy -0.428695652 0 0 kegg kegg NA NA no no no no no no Bladder cancer Diabetic cardiomyopathy 0 -0.739130435 -0.418018018 kegg kegg NA NA no no no no no no Breast cancer Diabetic cardiomyopathy 0 -0.649209486 0 kegg kegg NA NA no no no no no no Butanoate metabolism Diabetic cardiomyopathy -0.610434783 0 0 kegg kegg NA NA no no no no no no Butyricimonas Diabetic cardiomyopathy 0.412392684 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no C-type lectin receptor signaling pathway Diabetic cardiomyopathy 0 -0.605731225 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Diabetic cardiomyopathy 0.708695652 0.73715415 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Diabetic cardiomyopathy 0.759130435 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Diabetic cardiomyopathy 0 -0.456521739 0 kegg kegg NA NA no no no no no no Carbon metabolism Diabetic cardiomyopathy -0.724347826 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Diabetic cardiomyopathy 0.982608696 0.980237154 0.968854569 kegg kegg NA NA no no up no no no Cell adhesion molecules Diabetic cardiomyopathy -0.509565217 -0.41798419 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Diabetic cardiomyopathy 0 -0.621541502 0 kegg kegg NA NA no no no no no no Chagas disease Diabetic cardiomyopathy 0 -0.463438735 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Diabetic cardiomyopathy -0.450434783 -0.501976285 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Diabetic cardiomyopathy 0.454782609 0 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Diabetic cardiomyopathy 0 -0.43083004 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Diabetic cardiomyopathy 0 -0.467391304 0 kegg kegg NA NA no no no no no no Circadian entrainment Diabetic cardiomyopathy 0 0.587944664 0 kegg kegg NA NA no up up no no no Circadian rhythm Diabetic cardiomyopathy 0.613043478 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Diabetic cardiomyopathy 0 0.415019763 0 kegg kegg NA NA no no no no no no Cocaine addiction Diabetic cardiomyopathy 0 0.472332016 0 kegg kegg NA NA no no no no no no Colorectal cancer Diabetic cardiomyopathy 0.613913043 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Diabetic cardiomyopathy -0.517391304 -0.627470356 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Diabetic cardiomyopathy 0.674782609 0.876482213 0 kegg kegg NA NA no no no no no no Cushing syndrome Diabetic cardiomyopathy 0.430434783 0.434782609 0 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Diabetic cardiomyopathy 0 0.482213439 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Diabetic cardiomyopathy 0 -0.42687747 0 kegg kegg NA NA no no no no no no Dilated cardiomyopathy Diabetic cardiomyopathy 0 0.701581028 0.498069498 kegg kegg NA NA no up up no no no DNA replication Diabetic cardiomyopathy 0 0.43083004 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Diabetic cardiomyopathy 0.622608696 0.707509881 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Diabetic cardiomyopathy 0 0.486166008 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Diabetic cardiomyopathy -0.547826087 0.561264822 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Diabetic cardiomyopathy 0 0.693675889 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Diabetic cardiomyopathy 0.52173913 0.786561265 0 kegg kegg NA NA no no no no no no Endocytosis Diabetic cardiomyopathy -0.423478261 -0.447628458 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Diabetic cardiomyopathy 0 -0.550395257 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Diabetic cardiomyopathy 0 -0.427865613 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Diabetic cardiomyopathy 0.646086957 0.441699605 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Diabetic cardiomyopathy -0.462608696 -0.614624506 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Diabetic cardiomyopathy 0 -0.800395257 -0.545688546 kegg kegg NA NA no no no no no no Fatty acid degradation Diabetic cardiomyopathy -0.626086957 -0.860671937 0 kegg kegg NA NA no no no no no no Fatty acid elongation Diabetic cardiomyopathy -0.479130435 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Diabetic cardiomyopathy -0.724347826 -0.827075099 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Diabetic cardiomyopathy 0 -0.690711462 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Diabetic cardiomyopathy -0.409565217 -0.626482213 0 kegg kegg NA NA no no no no no no Focal adhesion Diabetic cardiomyopathy 0 0.535573123 0.51042471 kegg kegg NA NA no up up no no no Folate biosynthesis Diabetic cardiomyopathy 0 0.440711462 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Diabetic cardiomyopathy 0 -0.76284585 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Diabetic cardiomyopathy -0.766086957 -0.59486166 -0.501415701 kegg kegg NA NA no no no no no no GABAergic synapse Diabetic cardiomyopathy 0 -0.640316206 0 kegg kegg NA NA no up up no no no Galactose metabolism Diabetic cardiomyopathy -0.742608696 -0.76284585 0 kegg kegg NA NA no no no no no no Gastric acid secretion Diabetic cardiomyopathy 0 0.726284585 0.594594595 kegg kegg NA NA no no no no no no Glioma Diabetic cardiomyopathy 0.445217391 0 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Diabetic cardiomyopathy 0 0.746047431 0 kegg kegg NA NA no no no no no no Glutathione metabolism Diabetic cardiomyopathy 0 0.688735178 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Diabetic cardiomyopathy 0 -0.636363636 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Diabetic cardiomyopathy 0 -0.414031621 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Diabetic cardiomyopathy -0.622608696 0.458498024 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Diabetic cardiomyopathy 0 -0.748023715 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Diabetic cardiomyopathy 0.508695652 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Diabetic cardiomyopathy 0 -0.423913043 0 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Diabetic cardiomyopathy -0.648695652 -0.723320158 -0.537709138 kegg kegg NA NA no no no no no no GnRH signaling pathway Diabetic cardiomyopathy 0 0.469367589 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Diabetic cardiomyopathy -0.433913043 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Diabetic cardiomyopathy 0.480869565 0 0 kegg kegg NA NA no no no no no no Hepatitis B Diabetic cardiomyopathy 0 -0.801383399 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Diabetic cardiomyopathy 0 0.611660079 0.619305019 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Diabetic cardiomyopathy 0 0.664031621 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Diabetic cardiomyopathy 0 0.654150198 0.62985843 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Diabetic cardiomyopathy 0 -0.742094862 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Diabetic cardiomyopathy -0.464347826 -0.416007905 0 kegg kegg NA NA no no no no no no Huntington disease Diabetic cardiomyopathy 0.977391304 0.990118577 0.948777349 kegg kegg NA NA no no no no no no Hypertrophic cardiomyopathy Diabetic cardiomyopathy 0 0.554347826 0.526640927 kegg kegg NA NA no up up no no no IL-17 signaling pathway Diabetic cardiomyopathy 0 -0.529644269 -0.416731017 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Diabetic cardiomyopathy 0.519130435 0.803359684 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Diabetic cardiomyopathy 0 -0.486166008 0 kegg kegg NA NA no no no no no no Insulin resistance Diabetic cardiomyopathy 0 -0.54743083 0 kegg kegg NA NA no no no no no no Insulin secretion Diabetic cardiomyopathy 0 0.510869565 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Diabetic cardiomyopathy 0 0.70256917 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Diabetic cardiomyopathy 0 -0.757905138 0 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Diabetic cardiomyopathy 0 0.449604743 0 kegg kegg NA NA no no dn no no no Legionellosis Diabetic cardiomyopathy -0.413913043 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Diabetic cardiomyopathy -0.533913043 0 0 kegg kegg NA NA no no no no no no Long-term depression Diabetic cardiomyopathy 0.582608696 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Diabetic cardiomyopathy 0.434782609 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Diabetic cardiomyopathy 0 -0.683794466 0 kegg kegg NA NA no no no no no no Melanogenesis Diabetic cardiomyopathy 0.508695652 0.835968379 0 kegg kegg NA NA no no no no no no Melanoma Diabetic cardiomyopathy 0 -0.456521739 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Diabetic cardiomyopathy 0 0.442687747 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Diabetic cardiomyopathy 0 -0.618577075 0 kegg kegg NA NA no no no no no no Mineral absorption Diabetic cardiomyopathy 0.416521739 0.600790514 0 kegg kegg NA NA no no no no no no Mitophagy - animal Diabetic cardiomyopathy 0.500869565 0.802371542 0 kegg kegg NA NA no no no no no no Morphine addiction Diabetic cardiomyopathy 0.532173913 0.593873518 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Diabetic cardiomyopathy 0.680869565 0.635375494 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Diabetic cardiomyopathy 0 0.684782609 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Diabetic cardiomyopathy 0 -0.427865613 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Diabetic cardiomyopathy 0 0.552371542 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Diabetic cardiomyopathy -0.417391304 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Diabetic cardiomyopathy 0 -0.495059289 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Diabetic cardiomyopathy 0.549565217 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Diabetic cardiomyopathy -0.423478261 -0.502964427 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Diabetic cardiomyopathy 0 -0.730237154 -0.403088803 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Diabetic cardiomyopathy 0 -0.735177866 -0.464092664 kegg kegg NA NA no no no no no no Nitrogen metabolism Diabetic cardiomyopathy -0.43826087 -0.623517787 -0.463320463 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Diabetic cardiomyopathy 0 -0.760869565 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Diabetic cardiomyopathy 0.966086957 0.953557312 0.877220077 kegg kegg NA NA no no no no no no Non-homologous end-joining Diabetic cardiomyopathy -0.629565217 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Diabetic cardiomyopathy 0 -0.416996047 0 kegg kegg NA NA no no no no no no Olfactory transduction Diabetic cardiomyopathy 0 -0.576086957 0 kegg kegg NA NA no no no no no no Oocyte meiosis Diabetic cardiomyopathy 0.416521739 0.461462451 0 kegg kegg NA NA no no no no no no Oscillospira Diabetic cardiomyopathy 0 -0.520750988 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Diabetic cardiomyopathy 0 -0.704545455 0 kegg kegg NA NA no no no no no no Other glycan degradation Diabetic cardiomyopathy 0 -0.532608696 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Diabetic cardiomyopathy 0.988695652 0.998023715 0.990990991 kegg kegg NA NA no no no no no no Pancreatic secretion Diabetic cardiomyopathy 0.673913043 0.720355731 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Diabetic cardiomyopathy 0 -0.776679842 -0.453796654 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Diabetic cardiomyopathy 0.644347826 0.791501976 0 kegg kegg NA NA no no no no no no Parkinson disease Diabetic cardiomyopathy 0.810434783 0.956521739 0 kegg kegg NA NA no no no no no no Pathways in cancer Diabetic cardiomyopathy 0.557391304 -0.435770751 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Diabetic cardiomyopathy 0.812173913 0.946640316 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Diabetic cardiomyopathy 0 -0.543478261 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Diabetic cardiomyopathy 0 0.528656126 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Diabetic cardiomyopathy -0.460869565 -0.538537549 -0.421879022 kegg kegg NA NA no no no no no no Peroxisome Diabetic cardiomyopathy -0.573913043 -0.736166008 0 kegg kegg NA NA no no no no no no Pertussis Diabetic cardiomyopathy 0 -0.654150198 0 kegg kegg NA NA no no dn no no no Phagosome Diabetic cardiomyopathy -0.533043478 -0.420948617 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Diabetic cardiomyopathy 0.517391304 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Diabetic cardiomyopathy 0 -0.54743083 0 kegg kegg NA NA no up up no no no Phototransduction Diabetic cardiomyopathy 0 0.538537549 0.429086229 kegg kegg NA NA no no no no no no Platelet activation Diabetic cardiomyopathy 0 0.54743083 0.429086229 kegg kegg NA NA no no no no no no PPAR signaling pathway Diabetic cardiomyopathy 0 -0.595849802 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Diabetic cardiomyopathy -0.444347826 0 0 kegg kegg NA NA no no no no no no Prion disease Diabetic cardiomyopathy 0.964347826 0.977272727 0.96036036 kegg kegg NA NA no no no no no no Prolactin signaling pathway Diabetic cardiomyopathy 0 -0.619565217 0 kegg kegg NA NA no no no no no no Propanoate metabolism Diabetic cardiomyopathy 0 0.456521739 0 kegg kegg NA NA no no no no no no Proteasome Diabetic cardiomyopathy 0 0.494071146 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Diabetic cardiomyopathy -0.633913043 -0.837944664 -0.43011583 yes kegg kegg NA NA no up up no no no Protein export Diabetic cardiomyopathy 0.480869565 0.773715415 0.445045045 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Diabetic cardiomyopathy 0 0.610671937 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Diabetic cardiomyopathy 0 0.736166008 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Diabetic cardiomyopathy 0 0.473320158 0 kegg kegg NA NA no no no no no no Purine metabolism Diabetic cardiomyopathy 0 0.41798419 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Diabetic cardiomyopathy -0.728695652 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Diabetic cardiomyopathy 0 0.574110672 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Diabetic cardiomyopathy 0 0.444664032 0.438095238 kegg kegg NA NA no no no no no no Ras signaling pathway Diabetic cardiomyopathy 0 0.519762846 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Diabetic cardiomyopathy 0 0 0.411583012 kegg kegg NA NA no no no no no no Relaxin signaling pathway Diabetic cardiomyopathy 0.504347826 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Diabetic cardiomyopathy 0.514782609 0 0 kegg kegg NA NA no no no no no no Renin secretion Diabetic cardiomyopathy 0 0.813241107 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Diabetic cardiomyopathy 0 -0.570158103 0 kegg kegg NA NA no no no no no no Retinol metabolism Diabetic cardiomyopathy -0.471304348 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Diabetic cardiomyopathy 0.833913043 0.929841897 0.77992278 kegg kegg NA NA no no up no no no Rheumatoid arthritis Diabetic cardiomyopathy 0 -0.567193676 0 kegg kegg NA NA no no no no no no Ribosome Diabetic cardiomyopathy 0.673043478 0.881422925 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Diabetic cardiomyopathy 0 -0.685770751 0 kegg kegg NA NA no no no no no no RNA degradation Diabetic cardiomyopathy 0.63826087 0.669960474 0 kegg kegg NA NA no no no no no no RNA polymerase Diabetic cardiomyopathy 0 0.541501976 0 kegg kegg NA NA no no no no no no RNA transport Diabetic cardiomyopathy 0 0.575098814 0 kegg kegg NA NA no no no no no no Shigellosis Diabetic cardiomyopathy 0.5 0.824110672 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Diabetic cardiomyopathy 0.571304348 0 0 kegg kegg NA NA no no no no no no Small cell lung cancer Diabetic cardiomyopathy 0 -0.524703557 0 kegg kegg NA NA no no up no no no SNARE interactions in vesicular transport Diabetic cardiomyopathy 0 -0.698616601 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Diabetic cardiomyopathy 0.450434783 0 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Diabetic cardiomyopathy -0.493043478 -0.450592885 0 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Diabetic cardiomyopathy -0.452173913 -0.809288538 0 kegg kegg NA NA no no no no no no Sulfur metabolism Diabetic cardiomyopathy -0.457391304 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Diabetic cardiomyopathy 0 -0.538537549 0 kegg kegg NA NA no up up no no no Systemic lupus erythematosus Diabetic cardiomyopathy -0.42 -0.440711462 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Diabetic cardiomyopathy 0 -0.510869565 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Diabetic cardiomyopathy 0 -0.425889328 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Diabetic cardiomyopathy 0.703478261 0.685770751 0.41029601 kegg kegg NA NA no no no no no no Th17 cell differentiation Diabetic cardiomyopathy 0 -0.419960474 0 kegg kegg NA NA no no no no no no Thermogenesis Diabetic cardiomyopathy 0.953913043 0.986166008 0.941312741 kegg kegg NA NA no no no no no no Thiamine metabolism Diabetic cardiomyopathy 0 0.421936759 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Diabetic cardiomyopathy 0 0.646245059 0.624710425 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Diabetic cardiomyopathy 0 0.592885375 0 kegg kegg NA NA no no no no no no Tight junction Diabetic cardiomyopathy 0 0.537549407 0 kegg kegg NA NA no no no no no no TNF signaling pathway Diabetic cardiomyopathy 0 -0.54743083 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Diabetic cardiomyopathy 0 -0.635375494 0 yes kegg kegg NA NA no no no no no no Toxoplasmosis Diabetic cardiomyopathy 0 -0.617588933 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Diabetic cardiomyopathy 0 -0.701581028 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Diabetic cardiomyopathy -0.554782609 0 0 kegg kegg NA NA no up no no no no Tuberculosis Diabetic cardiomyopathy -0.44173913 -0.553359684 0 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Diabetic cardiomyopathy -0.431304348 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Diabetic cardiomyopathy 0 -0.598814229 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Diabetic cardiomyopathy -0.412173913 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Diabetic cardiomyopathy 0.490434783 0.81027668 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Diabetic cardiomyopathy -0.493913043 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Diabetic cardiomyopathy 0.693043478 0.858695652 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Diabetic cardiomyopathy 0.550434783 0.758893281 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Diabetic cardiomyopathy 0 0.619565217 0.502445302 kegg kegg NA NA no no no no no no Viral carcinogenesis Diabetic cardiomyopathy 0 -0.488142292 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Diabetic cardiomyopathy 0.617391304 -0.428853755 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Diabetic cardiomyopathy 0.69826087 0.645256917 0.415701416 kegg kegg NA NA no no no no no no 15-HETE+blood Diastolic_Pressure+clinic 0 0 0.405449495 serum_ARA clinic 0.819 0.0346 no no no up no no 16:0/16:1-PC+blood Diastolic_Pressure+clinic 0 -0.596428571 0 serum_phospholipids clinic 0.00283 0.0346 up up no up no no 16:0/18:2-PI+blood Diastolic_Pressure+clinic 0 -0.660714286 0 serum_phospholipids clinic 0.269 0.0346 no no no up no no 16:0/18:3-PC+blood Diastolic_Pressure+clinic 0.496388029 0 0 serum_phospholipids clinic 0.00216 0.0346 no up up up no no 16:0/22:6-PC+blood Diastolic_Pressure+clinic 0 0.528571429 0 serum_phospholipids clinic 4.53E-05 0.0346 no up up up no no 16:1/18:2-PG+blood Diastolic_Pressure+clinic 0 -0.678571429 0 serum_phospholipids clinic 1.40E-08 0.0346 no up up up no no 18:0-LPA+blood Diastolic_Pressure+clinic 0 0 -0.401538462 serum_phospholipids clinic 0.0725 0.0346 no dn no up no no 18:0/18:2-PI+blood Diastolic_Pressure+clinic 0 -0.557142857 0 serum_phospholipids clinic 0.179 0.0346 no no no up no no 18:0/20:4-PC+blood Diastolic_Pressure+clinic 0 0.639285714 0 serum_phospholipids clinic 0.454 0.0346 no no no up no no 18:0/20:5-PC+blood Diastolic_Pressure+clinic 0 0.75 0 serum_phospholipids clinic 0.17 0.0346 no no no up no no 18:1/18:1-PE+blood Diastolic_Pressure+clinic 0 -0.653571429 0 serum_phospholipids clinic 1.03E-05 0.0346 up up no up no no 18:1/18:2-PI+blood Diastolic_Pressure+clinic 0 0 -0.409230769 serum_phospholipids clinic 0.0164 0.0346 dn no up up no no 18:1/20:4-PC+blood Diastolic_Pressure+clinic 0 0.689285714 0 serum_phospholipids clinic 0.582 0.0346 no no no up no no 20:1-LPA+blood Diastolic_Pressure+clinic 0 0 -0.427692308 serum_phospholipids clinic 0.0187 0.0346 dn dn no up no no 20:3n6+blood Diastolic_Pressure+clinic 0 -0.596428571 0 serum_fattyacid clinic 0.0884 0.0346 up no no up no no 20:4-LPC+blood Diastolic_Pressure+clinic 0 0.564285714 0 serum_phospholipids clinic 0.949 0.0346 no no no up no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Diastolic_Pressure+clinic -0.473684211 0 0 urine_cometabolism clinic 0.0125 0.0346 up up no up no no 4-hydroxybenzoic acid+urine Diastolic_Pressure+clinic 0 0.487745098 0 urine_cometabolism clinic 0.52 0.0346 no no no up no no 9-HODE+blood Diastolic_Pressure+clinic 0 0 0.54 serum_ARA clinic 0.297 0.0346 no no no up no no AA+blood Diastolic_Pressure+clinic 0 0.607142857 0 serum_ARA clinic 0.212 0.0346 no no no up no no ACA+stool Diastolic_Pressure+clinic -0.511968578 0 0 stool_bileacids clinic 0.417 0.0346 no no no up no no Aldosterone synthesis and secretion Diastolic_Pressure+clinic -0.50310559 0 0 kegg clinic NA 0.0346 no up up up no no Amphetamine addiction Diastolic_Pressure+clinic -0.439864483 0 0 kegg clinic NA 0.0346 no no no up no no Anaerostipes Diastolic_Pressure+clinic 0.518833588 0 0 butyrate-producing Genus clinic 0.568 0.0346 no no no up no no Antigen processing and presentation Diastolic_Pressure+clinic 0.5256917 0 0 kegg clinic NA 0.0346 no no no up no no Breast cancer Diastolic_Pressure+clinic -0.477131564 0 0 kegg clinic NA 0.0346 no no no up no no C-peptide Diastolic_Pressure+clinic -0.469367589 -0.623941276 -0.449656226 DM-assocaited hormones clinic 0.228 0.0346 no no no up no no CA+blood Diastolic_Pressure+clinic 0 0 0.496528798 serum_bileacids clinic 0.606 0.0346 no no no up no no Chemical carcinogenesis - receptor activation Diastolic_Pressure+clinic -0.512140034 0 0 kegg clinic NA 0.0346 no no no up no no Choline metabolism in cancer Diastolic_Pressure+clinic -0.454545455 0 0 kegg clinic NA 0.0346 no no no up no no Choline+blood Diastolic_Pressure+clinic -0.545923633 0 -0.406153846 serum_choline clinic 0.0395 0.0346 no up no up no no Colorectal cancer Diastolic_Pressure+clinic -0.51552795 0 0 kegg clinic NA 0.0346 no no no up no no Cushing syndrome Diastolic_Pressure+clinic -0.587803501 0 0 kegg clinic NA 0.0346 no no up up no no Dorea Diastolic_Pressure+clinic 0.47826087 0 0 Genus clinic 0.00362 0.0346 up no dn up no no Endocrine resistance Diastolic_Pressure+clinic -0.57312253 0 0 kegg clinic NA 0.0346 no no no up no no EPA+blood Diastolic_Pressure+clinic 0 0.657142857 0 serum_ARA clinic 0.212 0.0346 no no no up no no ErbB signaling pathway Diastolic_Pressure+clinic -0.482778091 0 0 kegg clinic NA 0.0346 no no no up no no Gastric cancer Diastolic_Pressure+clinic -0.549407115 0 0 kegg clinic NA 0.0346 no no no up no no GCDCA+stool Diastolic_Pressure+clinic 0 -0.627272727 0 yes stool_bileacids clinic 0.0471 0.0346 no dn no up no no Glycolysis / Gluconeogenesis Diastolic_Pressure+clinic 0.460191982 0 0 kegg clinic NA 0.0346 no no no up no no GnRH signaling pathway Diastolic_Pressure+clinic -0.498588368 0 0 kegg clinic NA 0.0346 no no no up no no "Growth hormone synthesis, secretion and action" Diastolic_Pressure+clinic -0.631846414 0 0 kegg clinic NA 0.0346 no no no up no no Herpes simplex virus 1 infection Diastolic_Pressure+clinic 0.541501976 0 0 kegg clinic NA 0.0346 no no no up no no Human T-cell leukemia virus 1 infection Diastolic_Pressure+clinic 0.505364201 0 0 kegg clinic NA 0.0346 no no no up no no IL-17 signaling pathway Diastolic_Pressure+clinic 0 0 -0.434733894 kegg clinic NA 0.0346 no no no up no no Kaposi sarcoma-associated herpesvirus infection Diastolic_Pressure+clinic -0.488424619 -0.484415584 0 kegg clinic NA 0.0346 no no dn up no no L-2-Aminobutyric acid+blood Diastolic_Pressure+clinic 0 0.521428571 0 yes serum_aminoacids clinic 0.000328 0.0346 up up no up no no L-Isoleucine+blood Diastolic_Pressure+clinic 0 0 -0.583846154 yes serum_aminoacids clinic 5.47E-06 0.0346 up up no up no no L-Leucine+blood Diastolic_Pressure+clinic 0 0 -0.466923077 yes serum_aminoacids clinic 3.22E-05 0.0346 up up no up no no L-Phenylalanine+blood Diastolic_Pressure+clinic 0 -0.525 -0.546153846 yes serum_aminoacids clinic 0.0103 0.0346 up up no up no no L-Proline+blood Diastolic_Pressure+clinic 0 -0.742857143 0 yes serum_aminoacids clinic 0.00265 0.0346 up up no up no no L-Tryptophan+blood Diastolic_Pressure+clinic 0 -0.564285714 0 serum_aminoacids clinic 0.164 0.0346 no no no up no no L-Tyrosine+blood Diastolic_Pressure+clinic 0 -0.557142857 0 yes serum_aminoacids clinic 0.00913 0.0346 up up no up no no Legionellosis Diastolic_Pressure+clinic 0.43083004 0 0 kegg clinic NA 0.0346 no no no up no no Leishmaniasis Diastolic_Pressure+clinic 0.471485037 0 0 kegg clinic NA 0.0346 no no no up no no Long-term depression Diastolic_Pressure+clinic -0.424054207 0 0 kegg clinic NA 0.0346 no no no up no no Long-term potentiation Diastolic_Pressure+clinic 0 0.580519481 0 kegg clinic NA 0.0346 no no up up no no Longevity regulating pathway Diastolic_Pressure+clinic -0.501976285 0 0 kegg clinic NA 0.0346 no no no up no no Morphine addiction Diastolic_Pressure+clinic -0.479390175 0 0 kegg clinic NA 0.0346 no up up up no no Necroptosis Diastolic_Pressure+clinic 0 -0.457142857 0 kegg clinic NA 0.0346 no no no up no no Parabacteroides Diastolic_Pressure+clinic 0 0.578769057 0 Genus clinic 4.19E-05 0.0346 no up up up no no Primary immunodeficiency Diastolic_Pressure+clinic 0.57312253 0 0 kegg clinic NA 0.0346 no no no up no no RANTES Diastolic_Pressure+clinic 0 0 0.618226601 yes serum_cytokines clinic 0.0757 0.0346 no no up up no no Regulation of actin cytoskeleton Diastolic_Pressure+clinic 0.451157538 0 0 kegg clinic NA 0.0346 no no no up no no Relaxin signaling pathway Diastolic_Pressure+clinic -0.450028233 0 0 kegg clinic NA 0.0346 no no no up no no Retrograde endocannabinoid signaling Diastolic_Pressure+clinic 0 0 0.407002801 kegg clinic NA 0.0346 no no up up no no Roseburia Diastolic_Pressure+clinic 0 -0.53374755 0 butyrate-producing Genus clinic 0.495 0.0346 no no no up no no Salmonella infection Diastolic_Pressure+clinic 0.436476567 0 0 kegg clinic NA 0.0346 no no no up no no Signaling pathways regulating pluripotency of stem cells Diastolic_Pressure+clinic -0.477131564 0 0 kegg clinic NA 0.0346 no no no up no no TCA+stool Diastolic_Pressure+clinic 0.533925627 0 0 stool_bileacids clinic 0.458 0.0346 no no no up no no TXB2+blood Diastolic_Pressure+clinic 0 0.73217828 0 yes serum_ARA clinic 0.0644 0.0346 dn no no up no no Valine+blood Diastolic_Pressure+clinic -0.475748194 0 -0.645384615 yes serum_aminoacids clinic 1.22E-06 0.0346 up up no up no no Visfatin Diastolic_Pressure+clinic 0 0 0.463101604 DM-assocaited hormones clinic 0.0229 0.0346 dn no up up no no Wnt signaling pathway Diastolic_Pressure+clinic -0.473743648 0 0 kegg clinic NA 0.0346 no no no up no no 2-Oxocarboxylic acid metabolism Dilated cardiomyopathy 0 0.450592885 0 kegg kegg NA NA no no no no up up ABC transporters Dilated cardiomyopathy 0 -0.475296443 0 kegg kegg NA NA no up up no up up Adherens junction Dilated cardiomyopathy 0.893043478 0.92687747 0.803603604 kegg kegg NA NA no no no no up up Adipocytokine signaling pathway Dilated cardiomyopathy 0 -0.492094862 0 kegg kegg NA NA no no no no up up Adrenergic signaling in cardiomyocytes Dilated cardiomyopathy 0 0.563241107 0 kegg kegg NA NA no no up no up up AGE-RAGE signaling pathway in diabetic complications Dilated cardiomyopathy 0 -0.638339921 0 kegg kegg NA NA no no no no up up "Alanine, aspartate and glutamate metabolism" Dilated cardiomyopathy 0 -0.730237154 0 kegg kegg NA NA no no no no up up Aldosterone synthesis and secretion Dilated cardiomyopathy 0 0.493083004 0 kegg kegg NA NA no up up no up up alpha-Linolenic acid metabolism Dilated cardiomyopathy 0 -0.492094862 0 kegg kegg NA NA no no no no up up Alzheimer disease Dilated cardiomyopathy 0 0.698616601 0 kegg kegg NA NA no no no no up up Amoebiasis Dilated cardiomyopathy 0 0 0.507335907 kegg kegg NA NA no no no no up up Amphetamine addiction Dilated cardiomyopathy 0 0.509881423 0 kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis Dilated cardiomyopathy 0 0.716403162 0.525353925 kegg kegg NA NA no no no no up up Apelin signaling pathway Dilated cardiomyopathy -0.469565217 0.486166008 0 kegg kegg NA NA no no no no up up Apoptosis Dilated cardiomyopathy 0.41826087 0 0 kegg kegg NA NA no no no no up up Apoptosis - multiple species Dilated cardiomyopathy -0.570434783 -0.557312253 0 kegg kegg NA NA no no no no up up Arginine and proline metabolism Dilated cardiomyopathy 0 -0.640316206 0 kegg kegg NA NA no up no no up up Arginine biosynthesis Dilated cardiomyopathy 0 -0.654150198 0 kegg kegg NA NA no no no no up up Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy 0.967826087 0.961462451 0.825482625 kegg kegg NA NA no up up no up up Ascorbate and aldarate metabolism Dilated cardiomyopathy 0 0.416007905 0 kegg kegg NA NA no no no no up up Autophagy - animal Dilated cardiomyopathy -0.780869565 -0.867588933 -0.524324324 kegg kegg NA NA no no no no up up Autophagy - other Dilated cardiomyopathy -0.87826087 -0.735177866 -0.522779923 kegg kegg NA NA no no no no up up B cell receptor signaling pathway Dilated cardiomyopathy 0 -0.554347826 0 kegg kegg NA NA no no no no up up Bacterial invasion of epithelial cells Dilated cardiomyopathy 0.833913043 0.793478261 0.736164736 kegg kegg NA NA no no no no up up Basal transcription factors Dilated cardiomyopathy -0.666086957 0 -0.421621622 kegg kegg NA NA no no no no up up Base excision repair Dilated cardiomyopathy -0.539130435 0 0 kegg kegg NA NA no no no no up up Bifidobacterium Dilated cardiomyopathy 0 0.418030009 0 acetate-producing Genus kegg 0.105 NA no dn no no up up Bile secretion Dilated cardiomyopathy 0.490434783 0.616600791 0.454826255 kegg kegg NA NA no no no no up up Biosynthesis of amino acids Dilated cardiomyopathy 0 -0.422924901 0 kegg kegg NA NA no no no no up up Biosynthesis of cofactors Dilated cardiomyopathy 0.462608696 0 0 kegg kegg NA NA no no no no up up Bladder cancer Dilated cardiomyopathy 0 -0.574110672 0 kegg kegg NA NA no no no no up up Breast cancer Dilated cardiomyopathy -0.433913043 -0.694664032 0 kegg kegg NA NA no no no no up up Butanoate metabolism Dilated cardiomyopathy 0 0.424901186 0 kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway Dilated cardiomyopathy -0.573043478 -0.652173913 -0.416216216 kegg kegg NA NA no no no no up up Calcium signaling pathway Dilated cardiomyopathy 0 0.622529644 0 kegg kegg NA NA no up up no up up Carbohydrate digestion and absorption Dilated cardiomyopathy -0.527826087 -0.427865613 0 kegg kegg NA NA no no no no up up Cardiac muscle contraction Dilated cardiomyopathy 0 0.718379447 0.493178893 kegg kegg NA NA no no up no up up Central carbon metabolism in cancer Dilated cardiomyopathy -0.462608696 0 0 kegg kegg NA NA no no no no up up cGMP-PKG signaling pathway Dilated cardiomyopathy 0 -0.42687747 0 kegg kegg NA NA no no no no up up Chagas disease Dilated cardiomyopathy 0 -0.504940711 0 kegg kegg NA NA no no no no up up Choline metabolism in cancer Dilated cardiomyopathy -0.457391304 -0.501976285 0 kegg kegg NA NA no no no no up up Cholinergic synapse Dilated cardiomyopathy -0.450434783 0 0 kegg kegg NA NA no no no no up up Chronic myeloid leukemia Dilated cardiomyopathy -0.45826087 -0.463438735 0 kegg kegg NA NA no no no no up up Circadian entrainment Dilated cardiomyopathy 0.453043478 0.726284585 0.501930502 kegg kegg NA NA no up up no up up Circadian rhythm Dilated cardiomyopathy -0.602608696 0 -0.404633205 kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) Dilated cardiomyopathy 0 0.416996047 0 kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Dilated cardiomyopathy 0 0.544466403 0 kegg kegg NA NA no no no no up up Cytokine-cytokine receptor interaction Dilated cardiomyopathy 0 0 0.604118404 kegg kegg NA NA no no no no up up Dopaminergic synapse Dilated cardiomyopathy 0 0.647233202 0 kegg kegg NA NA no up no no up up Drug metabolism - cytochrome P450 Dilated cardiomyopathy 0 0.601778656 0 kegg kegg NA NA no no no no up up Drug metabolism - other enzymes Dilated cardiomyopathy 0 0.691699605 0 kegg kegg NA NA no no no no up up EGFR tyrosine kinase inhibitor resistance Dilated cardiomyopathy -0.473043478 0 0 kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Dilated cardiomyopathy 0.407826087 0.693675889 0.508622909 kegg kegg NA NA no no no no up up Endometrial cancer Dilated cardiomyopathy 0 -0.538537549 0 kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection Dilated cardiomyopathy 0 -0.462450593 0 kegg kegg NA NA no no no no up up ErbB signaling pathway Dilated cardiomyopathy -0.426956522 -0.489130435 0 kegg kegg NA NA no no no no up up Estrogen signaling pathway Dilated cardiomyopathy 0 0.449604743 0.447104247 kegg kegg NA NA no no no no up up Fatty acid biosynthesis Dilated cardiomyopathy 0 -0.668972332 0 kegg kegg NA NA no no no no up up Fatty acid degradation Dilated cardiomyopathy 0 -0.688735178 0 kegg kegg NA NA no no no no up up Fatty acid metabolism Dilated cardiomyopathy 0 -0.641304348 0 kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway Dilated cardiomyopathy 0 -0.553359684 0 kegg kegg NA NA no no no no up up Fc gamma R-mediated phagocytosis Dilated cardiomyopathy 0 -0.421936759 0 kegg kegg NA NA no no no no up up Focal adhesion Dilated cardiomyopathy 0.874782609 0.873517787 0.744144144 kegg kegg NA NA no up up no up up Folate biosynthesis Dilated cardiomyopathy 0 0.419960474 0 kegg kegg NA NA no no no no up up FoxO signaling pathway Dilated cardiomyopathy -0.433043478 -0.753952569 0 kegg kegg NA NA no no no no up up GABAergic synapse Dilated cardiomyopathy -0.41826087 -0.517786561 0 kegg kegg NA NA no up up no up up Galactose metabolism Dilated cardiomyopathy 0 -0.456521739 0 kegg kegg NA NA no no no no up up Gap junction Dilated cardiomyopathy 0.596521739 0 0.653539254 kegg kegg NA NA no no no no up up Gastric acid secretion Dilated cardiomyopathy 0.926086957 0.975296443 0.938481338 kegg kegg NA NA no no no no up up Glioma Dilated cardiomyopathy -0.462608696 -0.496047431 0 kegg kegg NA NA no no no no up up Glucagon signaling pathway Dilated cardiomyopathy 0 0.537549407 0 kegg kegg NA NA no no no no up up Glutathione metabolism Dilated cardiomyopathy 0 0.553359684 0 kegg kegg NA NA no no no no up up Glycerolipid metabolism Dilated cardiomyopathy 0 -0.544466403 0 kegg kegg NA NA no no up no up up Glycerophospholipid metabolism Dilated cardiomyopathy -0.471304348 -0.510869565 0 kegg kegg NA NA no no up no up up "Glycine, serine and threonine metabolism" Dilated cardiomyopathy 0.451304348 0 0 kegg kegg NA NA no up no no up up Glycolysis / Gluconeogenesis Dilated cardiomyopathy 0 0.469367589 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Dilated cardiomyopathy 0 -0.618577075 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Dilated cardiomyopathy 0.472173913 0 0 kegg kegg NA NA no no no no up up Glyoxylate and dicarboxylate metabolism Dilated cardiomyopathy 0 -0.673913043 0 kegg kegg NA NA no no no no up up GnRH secretion Dilated cardiomyopathy 0 -0.459486166 0 kegg kegg NA NA no up up no up up Hepatitis B Dilated cardiomyopathy -0.665217391 -0.842885375 0 kegg kegg NA NA no no no no up up Hepatitis C Dilated cardiomyopathy 0 -0.519762846 0 kegg kegg NA NA no no no no up up Hepatocellular carcinoma Dilated cardiomyopathy 0.849565217 0.922924901 0.694980695 kegg kegg NA NA no no no no up up HIF-1 signaling pathway Dilated cardiomyopathy -0.56173913 0 0 kegg kegg NA NA no no no no up up Hippo signaling pathway Dilated cardiomyopathy 0.860869565 0.884387352 0.765508366 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Dilated cardiomyopathy 0 -0.585968379 0 kegg kegg NA NA no no no no up up Huntington disease Dilated cardiomyopathy 0 0.710474308 0.462033462 kegg kegg NA NA no no no no up up Hypertrophic cardiomyopathy Dilated cardiomyopathy 0.956521739 0.949604743 0.836550837 kegg kegg NA NA no up up no up up Inflammatory mediator regulation of TRP channels Dilated cardiomyopathy 0 0.666007905 0 kegg kegg NA NA no no no no up up Influenza A Dilated cardiomyopathy 0.48173913 0 0.544401544 kegg kegg NA NA no no no no up up Inositol phosphate metabolism Dilated cardiomyopathy 0 -0.530632411 0 kegg kegg NA NA no no no no up up Insulin resistance Dilated cardiomyopathy -0.688695652 -0.641304348 -0.536936937 kegg kegg NA NA no no no no up up Insulin signaling pathway Dilated cardiomyopathy -0.542608696 0 -0.436036036 kegg kegg NA NA no no no no up up JAK-STAT signaling pathway Dilated cardiomyopathy 0 -0.717391304 0 kegg kegg NA NA no no no no up up Lachnospira Dilated cardiomyopathy 0 0.533234511 0 butyrate-producing Genus kegg 0.279 NA no no no no up up Leukocyte transendothelial migration Dilated cardiomyopathy 0.686086957 0.543478261 0.644015444 kegg kegg NA NA no no no no up up Linoleic acid metabolism Dilated cardiomyopathy 0 0.432806324 0 kegg kegg NA NA no no no no up up Long-term depression Dilated cardiomyopathy 0 0 0.475418275 kegg kegg NA NA no no no no up up Long-term potentiation Dilated cardiomyopathy -0.466086957 0 0 kegg kegg NA NA no no up no up up Lysine degradation Dilated cardiomyopathy -0.474782609 0 -0.42033462 kegg kegg NA NA no no no no up up MAPK signaling pathway Dilated cardiomyopathy 0 -0.647233202 0 kegg kegg NA NA no no no no up up Measles Dilated cardiomyopathy -0.435652174 0 0 kegg kegg NA NA no no no no up up Melanogenesis Dilated cardiomyopathy 0.453043478 0.682806324 0 kegg kegg NA NA no no no no up up Melanoma Dilated cardiomyopathy -0.575652174 -0.647233202 0 kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 Dilated cardiomyopathy 0 0.602766798 0 kegg kegg NA NA no no no no up up MicroRNAs in cancer Dilated cardiomyopathy 0 -0.722332016 0 kegg kegg NA NA no no no no up up Mitophagy - animal Dilated cardiomyopathy 0 0.448616601 0 kegg kegg NA NA no no no no up up Morphine addiction Dilated cardiomyopathy 0 0.666996047 0.462548263 kegg kegg NA NA no up up no up up mRNA surveillance pathway Dilated cardiomyopathy -0.473043478 0 0 kegg kegg NA NA no no no no up up mTOR signaling pathway Dilated cardiomyopathy -0.46 0 -0.446332046 kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis Dilated cardiomyopathy 0 -0.636363636 0 kegg kegg NA NA no no no no up up N-Glycan biosynthesis Dilated cardiomyopathy 0 0.526679842 0 kegg kegg NA NA no no no no up up Neurotrophin signaling pathway Dilated cardiomyopathy -0.410434783 -0.513833992 0 kegg kegg NA NA no no no no up up NF-kappa B signaling pathway Dilated cardiomyopathy -0.486086957 -0.73715415 -0.442471042 kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Dilated cardiomyopathy 0 -0.604743083 0 kegg kegg NA NA no no no no up up Nitrogen metabolism Dilated cardiomyopathy 0 -0.617588933 0 kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Dilated cardiomyopathy 0 -0.777667984 0 kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease Dilated cardiomyopathy 0 0.624505929 0.517374517 kegg kegg NA NA no no no no up up Non-small cell lung cancer Dilated cardiomyopathy -0.426956522 -0.431818182 0 kegg kegg NA NA no no no no up up Oscillospira Dilated cardiomyopathy 0 -0.45256917 0 LPS-producing Genus kegg 0.62 NA no no no no up up Osteoclast differentiation Dilated cardiomyopathy 0 -0.624505929 0 kegg kegg NA NA no no no no up up Other glycan degradation Dilated cardiomyopathy 0 -0.449604743 0 kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis Dilated cardiomyopathy -0.47826087 0 0 kegg kegg NA NA no no no no up up Ovarian steroidogenesis Dilated cardiomyopathy 0.607826087 0 0.519433719 kegg kegg NA NA no up up no up up Oxidative phosphorylation Dilated cardiomyopathy 0 0.709486166 0.4996139 kegg kegg NA NA no no no no up up Oxytocin signaling pathway Dilated cardiomyopathy 0.877391304 0.716403162 0.697297297 kegg kegg NA NA no no no no up up p53 signaling pathway Dilated cardiomyopathy -0.68 -0.522727273 -0.403088803 kegg kegg NA NA no no no no up up Pancreatic secretion Dilated cardiomyopathy 0 0.766798419 0.509395109 kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis Dilated cardiomyopathy 0 -0.631422925 0 kegg kegg NA NA no no dn no up up Paraprevotella Dilated cardiomyopathy 0 0.443448839 0 Genus kegg 0.118 NA no no no no up up "Parathyroid hormone synthesis, secretion and action" Dilated cardiomyopathy 0 0.45256917 0 kegg kegg NA NA no no no no up up Parkinson disease Dilated cardiomyopathy 0 0.631422925 0 kegg kegg NA NA no no no no up up Pathogenic Escherichia coli infection Dilated cardiomyopathy 0 0 0.543371943 kegg kegg NA NA no no no no up up Pathways in cancer Dilated cardiomyopathy -0.482608696 -0.479249012 0 kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases Dilated cardiomyopathy 0 0.598814229 0 kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer Dilated cardiomyopathy -0.56 -0.765810277 -0.51969112 kegg kegg NA NA no no no no up up Pentose and glucuronate interconversions Dilated cardiomyopathy 0 0.470355731 0 kegg kegg NA NA no no no no up up Peroxisome Dilated cardiomyopathy 0 -0.701581028 0 kegg kegg NA NA no no no no up up Pertussis Dilated cardiomyopathy 0 -0.419960474 0 kegg kegg NA NA no no dn no up up Phagosome Dilated cardiomyopathy 0.455652174 0 0 kegg kegg NA NA no no no no up up Phenylalanine metabolism Dilated cardiomyopathy 0.657391304 0.599802372 0.447361647 kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system Dilated cardiomyopathy -0.433043478 0 0 kegg kegg NA NA no no no no up up Phototransduction Dilated cardiomyopathy 0 0.475296443 0 kegg kegg NA NA no no no no up up PI3K-Akt signaling pathway Dilated cardiomyopathy -0.429565217 0 0 yes kegg kegg NA NA no up up no up up Platelet activation Dilated cardiomyopathy 0.951304348 0.920948617 0.934877735 kegg kegg NA NA no no no no up up Platinum drug resistance Dilated cardiomyopathy -0.619130435 -0.494071146 0 kegg kegg NA NA no no no no up up Porphyrin and chlorophyll metabolism Dilated cardiomyopathy 0.42173913 0 0 kegg kegg NA NA no no no no up up PPAR signaling pathway Dilated cardiomyopathy 0 -0.660079051 0 kegg kegg NA NA no no no no up up Prion disease Dilated cardiomyopathy 0 0.692687747 0.486743887 kegg kegg NA NA no no no no up up Progesterone-mediated oocyte maturation Dilated cardiomyopathy -0.624347826 -0.460474308 0 kegg kegg NA NA no no no no up up Prolactin signaling pathway Dilated cardiomyopathy 0 -0.518774704 0 kegg kegg NA NA no no no no up up Prostate cancer Dilated cardiomyopathy -0.54173913 -0.543478261 0 kegg kegg NA NA no no no no up up Proteasome Dilated cardiomyopathy -0.625217391 0 -0.484942085 kegg kegg NA NA no no no no up up Protein digestion and absorption Dilated cardiomyopathy 0 -0.670948617 0 yes kegg kegg NA NA no up up no up up Protein export Dilated cardiomyopathy -0.527826087 0.527667984 0 kegg kegg NA NA no no no no up up Protein processing in endoplasmic reticulum Dilated cardiomyopathy 0 0.454545455 0 kegg kegg NA NA no no no no up up Proteoglycans in cancer Dilated cardiomyopathy 0 0.543478261 0 kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation Dilated cardiomyopathy 0 0.51284585 0 kegg kegg NA NA no no no no up up Pyrimidine metabolism Dilated cardiomyopathy 0 0.484189723 -0.499099099 kegg kegg NA NA no no no no up up Rap1 signaling pathway Dilated cardiomyopathy 0.839130435 0.842885375 0.855855856 kegg kegg NA NA no no no no up up Ras signaling pathway Dilated cardiomyopathy 0 0.581027668 0 yes kegg kegg NA NA no up up no up up Regulation of actin cytoskeleton Dilated cardiomyopathy 0.617391304 0.558300395 0.556499356 kegg kegg NA NA no no no no up up Regulation of lipolysis in adipocytes Dilated cardiomyopathy 0 0.434782609 0.47953668 kegg kegg NA NA no no no no up up Renin secretion Dilated cardiomyopathy 0.486086957 0.743083004 0.444015444 kegg kegg NA NA no no no no up up Retrograde endocannabinoid signaling Dilated cardiomyopathy 0 0.731225296 0 kegg kegg NA NA no no up no up up Ribosome Dilated cardiomyopathy 0 0.552371542 0 kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes Dilated cardiomyopathy -0.474782609 0 0 kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway Dilated cardiomyopathy -0.626956522 -0.766798419 0 kegg kegg NA NA no no no no up up RNA degradation Dilated cardiomyopathy -0.487826087 0.463438735 0 kegg kegg NA NA no no no no up up RNA polymerase Dilated cardiomyopathy -0.560869565 0 0 kegg kegg NA NA no no no no up up Salivary secretion Dilated cardiomyopathy 0.486086957 0.624505929 0 kegg kegg NA NA no no no no up up Salmonella infection Dilated cardiomyopathy 0 0 0.544144144 kegg kegg NA NA no no no no up up Selenocompound metabolism Dilated cardiomyopathy -0.610434783 0 0 kegg kegg NA NA no no no no up up Serotonergic synapse Dilated cardiomyopathy 0.436521739 0 0.534105534 kegg kegg NA NA no no no no up up Shigellosis Dilated cardiomyopathy 0 0.460474308 0 kegg kegg NA NA no no no no up up Small cell lung cancer Dilated cardiomyopathy -0.495652174 -0.608695652 0 kegg kegg NA NA no no up no up up SNARE interactions in vesicular transport Dilated cardiomyopathy 0 -0.691699605 0 kegg kegg NA NA no no no no up up Spinocerebellar ataxia Dilated cardiomyopathy -0.84173913 0 -0.434491634 kegg kegg NA NA no no no no up up Spliceosome Dilated cardiomyopathy -0.657391304 -0.483201581 0 kegg kegg NA NA no no no no up up Starch and sucrose metabolism Dilated cardiomyopathy 0 -0.62055336 0 kegg kegg NA NA no no no no up up Sulfur metabolism Dilated cardiomyopathy 0.406956522 0 0 kegg kegg NA NA no no no no up up T cell receptor signaling pathway Dilated cardiomyopathy 0 -0.747035573 0 kegg kegg NA NA no no no no up up Taurine and hypotaurine metabolism Dilated cardiomyopathy 0 -0.482213439 0 kegg kegg NA NA no no no no up up Terpenoid backbone biosynthesis Dilated cardiomyopathy -0.454782609 0 0 kegg kegg NA NA no no no no up up TGF-beta signaling pathway Dilated cardiomyopathy 0 0.502964427 0 kegg kegg NA NA no no no no up up Th17 cell differentiation Dilated cardiomyopathy 0 -0.420948617 0 kegg kegg NA NA no no no no up up Thermogenesis Dilated cardiomyopathy 0 0.716403162 0.457142857 kegg kegg NA NA no no no no up up Thiamine metabolism Dilated cardiomyopathy 0 0 -0.461776062 kegg kegg NA NA no no no no up up Thyroid hormone signaling pathway Dilated cardiomyopathy 0.819130435 0.943675889 0.681853282 kegg kegg NA NA no no no no up up Thyroid hormone synthesis Dilated cardiomyopathy 0 0.476284585 0 kegg kegg NA NA no no no no up up Tight junction Dilated cardiomyopathy 0.743478261 0.796442688 0.54980695 kegg kegg NA NA no no no no up up TNF signaling pathway Dilated cardiomyopathy -0.422608696 -0.595849802 0 kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway Dilated cardiomyopathy 0 -0.613636364 0 yes kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Dilated cardiomyopathy -0.842608696 -0.828063241 -0.48957529 kegg kegg NA NA no no no no up up Type II diabetes mellitus Dilated cardiomyopathy -0.497391304 -0.647233202 -0.404118404 kegg kegg NA NA no no no no up up Tyrosine metabolism Dilated cardiomyopathy 0 0.496047431 0 kegg kegg NA NA no no no no up up Ubiquitin mediated proteolysis Dilated cardiomyopathy 0 0.475296443 0 kegg kegg NA NA no no no no up up Various types of N-glycan biosynthesis Dilated cardiomyopathy -0.433043478 0 0 kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Dilated cardiomyopathy 0 0.750988142 0 kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption Dilated cardiomyopathy 0.446956522 0.75 0.592020592 kegg kegg NA NA no no no no up up Vibrio cholerae infection Dilated cardiomyopathy 0.927826087 0.957509881 0.866666667 kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor Dilated cardiomyopathy 0 0 0.518146718 kegg kegg NA NA no no no no up up Wnt signaling pathway Dilated cardiomyopathy 0 0.542490119 0 kegg kegg NA NA no no no no up up Yersinia infection Dilated cardiomyopathy 0.42173913 0 0.626512227 kegg kegg NA NA no no no no up up 14:0/18:2-PC+blood DL-Indole-3-lactic acid+urine 0 0.78021978 0 serum_phospholipids urine_cometabolism 0.102 0.00552 no up no up up no 18:2n6c+blood DL-Indole-3-lactic acid+urine -0.531862745 0 0 serum_fattyacid urine_cometabolism 0.15 0.00552 no no no up up no 2-hydroxyphenylacetic acid+urine DL-Indole-3-lactic acid+urine -0.460150376 0 0 urine_cometabolism urine_cometabolism 0.763 0.00552 no no no up up no 20:1+blood DL-Indole-3-lactic acid+urine 0.485294118 0 0 yes serum_fattyacid urine_cometabolism 2.56E-05 0.00552 dn dn dn up up no 20:2+blood DL-Indole-3-lactic acid+urine 0 0.708791209 0 serum_fattyacid urine_cometabolism 0.478 0.00552 no no no up up no 20:4-LPC+blood DL-Indole-3-lactic acid+urine 0.676470588 0 0 serum_phospholipids urine_cometabolism 0.949 0.00552 no no no up up no 20:4n6+blood DL-Indole-3-lactic acid+urine 0.705882353 0 0 serum_fattyacid urine_cometabolism 0.133 0.00552 no no no up up no 24:0+blood DL-Indole-3-lactic acid+urine 0 0.615384615 0 serum_fattyacid urine_cometabolism 0.034 0.00552 dn no up up up no "3-(3,4-dihydroxyphenyl)propionic acid+urine" DL-Indole-3-lactic acid+urine 0.559398496 0.519298246 0.688888889 urine_cometabolism urine_cometabolism 0.0125 0.00552 up up no up up no 3-Hydroxy-L-kynurenine+urine DL-Indole-3-lactic acid+urine 0 0.612280702 0 urine_cometabolism urine_cometabolism 0.401 0.00552 no no no up up no 5-Hydroxyindole-3-acetic Acid+urine DL-Indole-3-lactic acid+urine 0 0 -0.433162393 urine_cometabolism urine_cometabolism 0.0405 0.00552 no dn dn up up no Alcoholism DL-Indole-3-lactic acid+urine 0 0 0.434615385 kegg urine_cometabolism NA 0.00552 no no no up up no Bacteroides DL-Indole-3-lactic acid+urine 0.503759398 0 0 LPS-producing Genus urine_cometabolism 0.000267 0.00552 dn dn up up up no Butyricicoccus DL-Indole-3-lactic acid+urine 0 -0.457083118 0 butyrate-producing Genus urine_cometabolism 0.852 0.00552 no no no up up no Calcium signaling pathway DL-Indole-3-lactic acid+urine 0 0.470175439 0 kegg urine_cometabolism NA 0.00552 no up up up up no Clostridium DL-Indole-3-lactic acid+urine 0 -0.549582541 0 Genus urine_cometabolism 0.925 0.00552 no no no up up no Collinsella DL-Indole-3-lactic acid+urine 0 -0.572935858 0 Genus urine_cometabolism 0.128 0.00552 no no no up up no d18:0-16:0-SM+blood DL-Indole-3-lactic acid+urine 0.50245098 0 0 serum_phospholipids urine_cometabolism 0.202 0.00552 no no no up up no d18:0-24:1-SM+blood DL-Indole-3-lactic acid+urine 0.482843137 0 0 serum_phospholipids urine_cometabolism 0.0609 0.00552 no dn dn up up no d18:1-14:0-SM+blood DL-Indole-3-lactic acid+urine 0.551470588 0 0 serum_phospholipids urine_cometabolism 0.94 0.00552 no no no up up no d18:1-16:0-SM+blood DL-Indole-3-lactic acid+urine 0.49754902 0 0 serum_phospholipids urine_cometabolism 0.14 0.00552 no no no up up no d18:1-16:1-SM+blood DL-Indole-3-lactic acid+urine 0.504901961 0 0 serum_phospholipids urine_cometabolism 0.2 0.00552 no no no up up no d18:1-22:1-SM+blood DL-Indole-3-lactic acid+urine 0.517156863 0 0 serum_phospholipids urine_cometabolism 0.222 0.00552 no no no up up no Endocrine resistance DL-Indole-3-lactic acid+urine 0 0.494736842 0 kegg urine_cometabolism NA 0.00552 no no no up up no Gap junction DL-Indole-3-lactic acid+urine 0 0.619298246 0 kegg urine_cometabolism NA 0.00552 no no no up up no Glutamatergic synapse DL-Indole-3-lactic acid+urine -0.498245614 0 0 kegg urine_cometabolism NA 0.00552 no up up up up no Long-term depression DL-Indole-3-lactic acid+urine 0 0.678947368 0 kegg urine_cometabolism NA 0.00552 no no no up up no Morphine addiction DL-Indole-3-lactic acid+urine 0 0.528070175 0 kegg urine_cometabolism NA 0.00552 no up up up up no n6+blood DL-Indole-3-lactic acid+urine 0 0.582417582 0 serum_fattyacid urine_cometabolism 0.153 0.00552 no no no up up no NF-kappa B signaling pathway DL-Indole-3-lactic acid+urine 0.512280702 0 0 kegg urine_cometabolism NA 0.00552 no no no up up no Parkinson disease DL-Indole-3-lactic acid+urine 0 0 0.434615385 kegg urine_cometabolism NA 0.00552 no no no up up no Pathways of neurodegeneration - multiple diseases DL-Indole-3-lactic acid+urine 0 0 0.453076923 kegg urine_cometabolism NA 0.00552 no no no up up no Regulation of lipolysis in adipocytes DL-Indole-3-lactic acid+urine 0 0.571929825 0 kegg urine_cometabolism NA 0.00552 no no no up up no Renin secretion DL-Indole-3-lactic acid+urine -0.496491228 0 0 kegg urine_cometabolism NA 0.00552 no no no up up no Salivary secretion DL-Indole-3-lactic acid+urine -0.529824561 0.478947368 0 kegg urine_cometabolism NA 0.00552 no no no up up no Thyroid hormone synthesis DL-Indole-3-lactic acid+urine 0 0.489473684 0 kegg urine_cometabolism NA 0.00552 no no no up up no 14:0/18:2-PC+blood DL-methionine sulfoxide+blood 0 -0.519607843 0 serum_phospholipids serum_aminoacids 0.102 0.302 no up no no no no 14:0/20:4-PC+blood DL-methionine sulfoxide+blood 0 -0.558823529 0 serum_phospholipids serum_aminoacids 0.486 0.302 no no no no no no 16:0/16:0-PC+blood DL-methionine sulfoxide+blood -0.455639098 0 0 serum_phospholipids serum_aminoacids 0.00079 0.302 no up up no no no 16:0/18:0-PC+blood DL-methionine sulfoxide+blood 0 -0.492647059 0 serum_phospholipids serum_aminoacids 0.521 0.302 no no no no no no 16:0/18:3-PC+blood DL-methionine sulfoxide+blood 0 -0.742647059 0 serum_phospholipids serum_aminoacids 0.00216 0.302 no up up no no no 16:0/20:5-PC+blood DL-methionine sulfoxide+blood 0 -0.68627451 0 serum_phospholipids serum_aminoacids 0.628 0.302 no no no no no no 18:1-LPE+blood DL-methionine sulfoxide+blood 0 0.575980392 0 serum_phospholipids serum_aminoacids 0.117 0.302 no no no no no no 18:2-LPA+blood DL-methionine sulfoxide+blood -0.445112782 0 0 serum_phospholipids serum_aminoacids 0.00684 0.302 dn no up no no no 18:3/18:2-PC+blood DL-methionine sulfoxide+blood 0 -0.529411765 -0.538461538 serum_phospholipids serum_aminoacids 0.0394 0.302 no no up no no no 20:0+blood DL-methionine sulfoxide+blood 0 0 0.439316239 yes serum_fattyacid serum_aminoacids 0.000278 0.302 dn no up no no no 20:3/18:0-PC+blood DL-methionine sulfoxide+blood 0 0 -0.423589744 serum_phospholipids serum_aminoacids 0.296 0.302 no no no no no no 20:5-LPC+blood DL-methionine sulfoxide+blood 0 0 0.446153846 serum_phospholipids serum_aminoacids 0.558 0.302 no no no no no no 20:5n3+blood DL-methionine sulfoxide+blood 0 -0.573529412 0 serum_fattyacid serum_aminoacids 0.988 0.302 no no no no no no ACA+blood DL-methionine sulfoxide+blood 0 0 -0.439056476 serum_bileacids serum_aminoacids 0.338 0.302 no no no no no no Choline+blood DL-methionine sulfoxide+blood 0 0 0.401025641 serum_choline serum_aminoacids 0.0395 0.302 no up no no no no Creatinine+blood DL-methionine sulfoxide+blood 0 0.659313725 0 serum_choline serum_aminoacids 0.437 0.302 no no no no no no Cystine+blood DL-methionine sulfoxide+blood 0 0.713235294 0 yes serum_aminoacids serum_aminoacids 0.00028 0.302 up up no no no no d18:0-18:3-SM+blood DL-methionine sulfoxide+blood 0 0 -0.455726496 serum_phospholipids serum_aminoacids 0.0879 0.302 no dn no no no no DCA+stool DL-methionine sulfoxide+blood -0.571428571 0 0 stool_bileacids serum_aminoacids 0.195 0.302 no no no no no no 12-HEPE+blood DMG+blood 0 -0.612531804 0 serum_ARA serum_choline 0.312 0.909 no no no no no no 14:0+blood DMG+blood -0.464661654 0 0 yes serum_fattyacid serum_choline 0.00572 0.909 up no dn no no no 16:0/18:2-PC+blood DMG+blood 0 0 0.522051282 serum_phospholipids serum_choline 3.24E-06 0.909 no up up no no no 16:0/20:5-PC+blood DMG+blood 0 -0.590686275 0 serum_phospholipids serum_choline 0.628 0.909 no no no no no no 16:0/22:6-PC+blood DMG+blood 0 0 0.44957265 serum_phospholipids serum_choline 4.53E-05 0.909 no up up no no no 16:1/16:0-PC+blood DMG+blood 0 0 0.411965812 serum_phospholipids serum_choline 0.0215 0.909 no up up no no no 18:0/18:2-PC+blood DMG+blood 0 0 0.508376068 serum_phospholipids serum_choline 1.74E-06 0.909 no up up no no no 18:0/20:4-PI+blood DMG+blood 0 -0.644607843 0 serum_phospholipids serum_choline 0.167 0.909 no no no no no no 18:0+blood DMG+blood 0 -0.580882353 0 serum_fattyacid serum_choline 0.344 0.909 no no no no no no 18:1/16:0-PC+blood DMG+blood 0 0 0.532307692 serum_phospholipids serum_choline 2.43E-05 0.909 no up up no no no 18:1/16:0-PI+blood DMG+blood -0.473684211 0 0 serum_phospholipids serum_choline 0.793 0.909 no no no no no no 18:1/18:0-PC+blood DMG+blood 0 0 0.483076923 serum_phospholipids serum_choline 1.83E-06 0.909 no up up no no no 18:1/18:0-PS+blood DMG+blood 0 -0.676470588 0 serum_phospholipids serum_choline 0.193 0.909 no no no no no no 18:2-LPA+blood DMG+blood 0 0.482843137 0 serum_phospholipids serum_choline 0.00684 0.909 dn no up no no no 18:2/16:0-PC+blood DMG+blood 0 0 0.519316239 serum_phospholipids serum_choline 8.67E-05 0.909 no up up no no no 18:2/20:4-PC+blood DMG+blood 0 -0.517156863 0 serum_phospholipids serum_choline 0.0145 0.909 no no up no no no 20:1/20:4-PC+blood DMG+blood 0 0 0.448888889 serum_phospholipids serum_choline 0.0419 0.909 no no up no no no 20:3/16:0-PC+blood DMG+blood 0 0 0.408547009 serum_phospholipids serum_choline 0.00405 0.909 no up up no no no 20:3/18:0-PI+blood DMG+blood 0 -0.615196078 0 serum_phospholipids serum_choline 0.289 0.909 no no no no no no 20:5n3+blood DMG+blood 0 -0.708333333 0 serum_fattyacid serum_choline 0.988 0.909 no no no no no no 22:6n3+blood DMG+blood 0 -0.519607843 0 serum_fattyacid serum_choline 0.792 0.909 no no no no no no 24:0+blood DMG+blood 0 0 -0.476239316 serum_fattyacid serum_choline 0.034 0.909 dn no up no no no 4-hydroxybenzoic acid+stool DMG+blood 0.664835165 0 0 stool_cometabolism serum_choline 0.0536 0.909 no dn no no no no "9,10-EPOME+blood" DMG+blood -0.629945993 0 0 serum_ARA serum_choline 0.801 0.909 no no no no no no Adherens junction DMG+blood 0 0.505882353 0 kegg serum_choline NA 0.909 no no no no no no Alistipes DMG+blood 0 -0.595953515 0 Genus serum_choline 0.0114 0.909 no up no no no no Bacterial invasion of epithelial cells DMG+blood 0 0.538235294 0 kegg serum_choline NA 0.909 no no no no no no Betaine+blood DMG+blood 0.508270677 0 0 serum_choline serum_choline 0.857 0.909 no no no no no no Bifidobacterium DMG+blood 0 0.705089035 0 acetate-producing Genus serum_choline 0.105 0.909 no dn no no no no Breast cancer DMG+blood 0 -0.585294118 0 kegg serum_choline NA 0.909 no no no no no no Choline+blood DMG+blood 0.542857143 0.482843137 0 serum_choline serum_choline 0.0395 0.909 no up no no no no Colorectal cancer DMG+blood 0 -0.667647059 0 kegg serum_choline NA 0.909 no no no no no no Creatinine+blood DMG+blood 0 0.568627451 0.429059829 serum_choline serum_choline 0.437 0.909 no no no no no no d18:0-24:1-SM+blood DMG+blood 0 0 -0.441367521 serum_phospholipids serum_choline 0.0609 0.909 no dn dn no no no d18:1-14:0-SM+blood DMG+blood 0 0 -0.441367521 serum_phospholipids serum_choline 0.94 0.909 no no no no no no d18:1-14:1-SM+blood DMG+blood 0 0 -0.431794872 serum_phospholipids serum_choline 0.0952 0.909 no dn no no no no d18:1-18:0-SM+blood DMG+blood 0 0 0.412649573 serum_phospholipids serum_choline 0.97 0.909 no no no no no no DCA+stool DMG+blood -0.703296703 0 0 stool_bileacids serum_choline 0.195 0.909 no no no no no no Dilated cardiomyopathy DMG+blood 0 0.564705882 -0.411538462 kegg serum_choline NA 0.909 no up up no no no DL-methionine sulfoxide+blood DMG+blood 0.609022556 0 0 serum_aminoacids serum_choline 0.302 0.909 no no no no no no ErbB signaling pathway DMG+blood 0 -0.647058824 0 kegg serum_choline NA 0.909 no no no no no no Estrogen signaling pathway DMG+blood -0.515789474 0 0 kegg serum_choline NA 0.909 no no no no no no FoxO signaling pathway DMG+blood 0 -0.605882353 0 kegg serum_choline NA 0.909 no no no no no no Gastric acid secretion DMG+blood 0 0.594117647 0 kegg serum_choline NA 0.909 no no no no no no Gastric cancer DMG+blood 0 -0.679411765 0 kegg serum_choline NA 0.909 no no no no no no Hepatocellular carcinoma DMG+blood 0 0 -0.461538462 kegg serum_choline NA 0.909 no no no no no no Hippo signaling pathway DMG+blood 0 0 -0.401538462 kegg serum_choline NA 0.909 no no no no no no Influenza A DMG+blood 0 0.508823529 0 kegg serum_choline NA 0.909 no no no no no no LCA+stool DMG+blood -0.565934066 0 0 stool_bileacids serum_choline 0.314 0.909 no no no no no no MAPK signaling pathway DMG+blood 0 -0.573529412 0 kegg serum_choline NA 0.909 no no no no no no Non-small cell lung cancer DMG+blood 0 -0.561764706 0 kegg serum_choline NA 0.909 no no no no no no Oxytocin signaling pathway DMG+blood 0 0.638235294 0 kegg serum_choline NA 0.909 no no no no no no Pancreatic cancer DMG+blood 0.459649123 -0.626470588 0 kegg serum_choline NA 0.909 no no no no no no Phosphatidylinositol signaling system DMG+blood 0 -0.555882353 0 kegg serum_choline NA 0.909 no no no no no no Platelet activation DMG+blood 0 0.541176471 0 kegg serum_choline NA 0.909 no no no no no no Platinum drug resistance DMG+blood 0 -0.579411765 0 kegg serum_choline NA 0.909 no no no no no no Progesterone-mediated oocyte maturation DMG+blood 0 -0.670588235 0 kegg serum_choline NA 0.909 no no no no no no Rap1 signaling pathway DMG+blood 0 0.547058824 0 kegg serum_choline NA 0.909 no no no no no no Serotonergic synapse DMG+blood -0.594736842 0 0 kegg serum_choline NA 0.909 no no no no no no Signaling pathways regulating pluripotency of stem cells DMG+blood 0 -0.65 0 kegg serum_choline NA 0.909 no no no no no no Spliceosome DMG+blood 0 -0.588235294 0 kegg serum_choline NA 0.909 no no no no no no TGF-beta signaling pathway DMG+blood 0.468421053 0 0 kegg serum_choline NA 0.909 no no no no no no Thyroid hormone signaling pathway DMG+blood 0 0.502941176 -0.506923077 kegg serum_choline NA 0.909 no no no no no no Tight junction DMG+blood 0 0.594117647 0 kegg serum_choline NA 0.909 no no no no no no Vascular smooth muscle contraction DMG+blood 0 0.535294118 0 kegg serum_choline NA 0.909 no no no no no no Vibrio cholerae infection DMG+blood 0 0.679411765 0 kegg serum_choline NA 0.909 no no no no no no Wnt signaling pathway DMG+blood 0.570175439 0 0 kegg serum_choline NA 0.909 no no no no no no 2-Oxocarboxylic acid metabolism DNA replication 0.502608696 0.824110672 0.503989704 kegg kegg NA NA no no no no no no ABC transporters DNA replication 0.442608696 0 0.405405405 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" DNA replication 0 -0.685770751 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis DNA replication 0.706086957 0.786561265 0.62960103 kegg kegg NA NA no no no no no no Antifolate resistance DNA replication 0.449565217 0.630434783 0.466666667 kegg kegg NA NA no no no no no no Arginine and proline metabolism DNA replication 0 -0.752964427 0 kegg kegg NA NA no up no no no no Arginine biosynthesis DNA replication 0 -0.730237154 -0.505019305 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism DNA replication 0.434782609 0.498023715 0.636036036 kegg kegg NA NA no no no no no no Basal transcription factors DNA replication 0.697391304 0.661067194 0.826769627 kegg kegg NA NA no no no no no no beta-Alanine metabolism DNA replication 0 0.522727273 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids DNA replication 0 -0.611660079 -0.518146718 kegg kegg NA NA no no no no no no Biosynthesis of cofactors DNA replication 0 0.622529644 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids DNA replication 0.617391304 0.4743083 0 kegg kegg NA NA no no no no no no Butanoate metabolism DNA replication 0.629565217 0.876482213 0.626512227 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) DNA replication 0.779130435 0.886363636 0.783783784 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism DNA replication 0.747826087 0.817193676 0.671042471 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 DNA replication 0 0.887351779 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes DNA replication 0 0.723320158 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance DNA replication 0.454782609 0.503952569 0.599227799 kegg kegg NA NA no no no no no no Ether lipid metabolism DNA replication 0 0.508893281 0.627541828 kegg kegg NA NA no no no no no no Fatty acid biosynthesis DNA replication 0 -0.68972332 0 kegg kegg NA NA no no no no no no Fatty acid elongation DNA replication 0 0.446640316 0 kegg kegg NA NA no no no no no no Folate biosynthesis DNA replication 0.427826087 0.454545455 0 kegg kegg NA NA no no no no no no Glutathione metabolism DNA replication 0 0.481225296 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism DNA replication 0 0 0.461518662 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism DNA replication 0 0 0.566280566 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis DNA replication 0.408695652 0.563241107 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate DNA replication -0.52 -0.658102767 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin DNA replication 0 0.614624506 0.453281853 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation DNA replication -0.624347826 -0.438735178 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series DNA replication 0 0.705533597 0.403346203 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series DNA replication 0 0 -0.407979408 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis DNA replication 0.577391304 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism DNA replication 0 -0.742094862 -0.447104247 kegg kegg NA NA no no no no no no Inositol phosphate metabolism DNA replication 0 0 0.487516088 kegg kegg NA NA no no no no no no Linoleic acid metabolism DNA replication 0 0.459486166 0.406177606 kegg kegg NA NA no no no no no no Lysine degradation DNA replication 0.448695652 0 0.581209781 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis DNA replication 0 0 0.482110682 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 DNA replication 0 0.838932806 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway DNA replication 0 0.583992095 0.54028314 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis DNA replication 0.5 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis DNA replication 0.665217391 0.834980237 0.635521236 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism DNA replication 0 -0.764822134 -0.425225225 kegg kegg NA NA no no no no no no Nitrogen metabolism DNA replication -0.50173913 -0.759881423 -0.57992278 kegg kegg NA NA no no no no no no One carbon pool by folate DNA replication 0.885217391 0.896245059 0.802316602 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis DNA replication 0.452173913 0 0.628571429 kegg kegg NA NA no no no no no no Oxidative phosphorylation DNA replication 0 0.42687747 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis DNA replication 0 -0.581027668 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions DNA replication 0.585217391 0.891304348 0.662548263 kegg kegg NA NA no no no no no no Pentose phosphate pathway DNA replication -0.497391304 -0.661067194 -0.494723295 kegg kegg NA NA no no no no no no Phenylalanine metabolism DNA replication 0 0.780632411 0 kegg kegg NA NA no no no no no no Platinum drug resistance DNA replication 0.557391304 0 0.441698842 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis DNA replication 0.795652174 0.4743083 0 kegg kegg NA NA no no no no no no Propanoate metabolism DNA replication 0.716521739 0.758893281 0.672072072 kegg kegg NA NA no no no no no no Pyrimidine metabolism DNA replication 0.428695652 0.806324111 0 kegg kegg NA NA no no no no no no Pyruvate metabolism DNA replication 0.833913043 0.825098814 0.568082368 kegg kegg NA NA no no no no no no Retinol metabolism DNA replication 0.553913043 0.779644269 0.682368082 kegg kegg NA NA no no no no no no Ribosome DNA replication 0 0.442687747 0.437580438 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes DNA replication 0.793913043 0.852766798 0.82007722 kegg kegg NA NA no no no no no no RNA degradation DNA replication 0 0.723320158 0.621364221 kegg kegg NA NA no no no no no no RNA polymerase DNA replication 0.653043478 0.855731225 0.824967825 kegg kegg NA NA no no no no no no RNA transport DNA replication 0.594782609 0.490118577 0 kegg kegg NA NA no no no no no no Selenocompound metabolism DNA replication 0.55826087 0.464426877 0.74980695 kegg kegg NA NA no no no no no no Sphingolipid metabolism DNA replication -0.611304348 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism DNA replication 0 -0.535573123 0 kegg kegg NA NA no no no no no no Steroid biosynthesis DNA replication 0.542608696 0.700592885 0.628828829 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis DNA replication 0.408695652 0.671936759 0.502445302 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies DNA replication 0.882608696 0.846837945 0.77039897 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis DNA replication 0.720869565 0.630434783 0.754440154 kegg kegg NA NA no no no no no no Thiamine metabolism DNA replication 0.43826087 0.587944664 0 kegg kegg NA NA no no no no no no Tryptophan metabolism DNA replication 0.64 0.709486166 0.538738739 kegg kegg NA NA no up no no no no Tyrosine metabolism DNA replication 0.564347826 0.822134387 0.476962677 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis DNA replication 0.693043478 0.87944664 0.852252252 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" DNA replication 0.824347826 0.884387352 0.708880309 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis DNA replication 0.542608696 0.747035573 0.625997426 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Dopaminergic synapse -0.606086957 0 0 kegg kegg NA NA no no no no up no ABC transporters Dopaminergic synapse -0.58173913 0 0 kegg kegg NA NA no up up no up no Adherens junction Dopaminergic synapse 0 0.530632411 0 kegg kegg NA NA no no no no up no Adrenergic signaling in cardiomyocytes Dopaminergic synapse 0.889565217 0.783596838 0.904761905 kegg kegg NA NA no no up no up no "Alanine, aspartate and glutamate metabolism" Dopaminergic synapse -0.409565217 -0.593873518 -0.453024453 kegg kegg NA NA no no no no up no alpha-Linolenic acid metabolism Dopaminergic synapse -0.751304348 -0.558300395 -0.607979408 kegg kegg NA NA no no no no up no Amino sugar and nucleotide sugar metabolism Dopaminergic synapse -0.523478261 0 -0.523037323 kegg kegg NA NA no no no no up no Aminoacyl-tRNA biosynthesis Dopaminergic synapse -0.579130435 0 0 kegg kegg NA NA no no no no up no AMPK signaling pathway Dopaminergic synapse 0 0.425889328 0 kegg kegg NA NA no no no no up no Apelin signaling pathway Dopaminergic synapse 0 0.593873518 0 kegg kegg NA NA no no no no up no Apoptosis Dopaminergic synapse -0.436521739 -0.616600791 0 kegg kegg NA NA no no no no up no Arginine and proline metabolism Dopaminergic synapse 0 -0.507905138 0 kegg kegg NA NA no up no no up no Arginine biosynthesis Dopaminergic synapse -0.427826087 -0.552371542 -0.428056628 kegg kegg NA NA no no no no up no Ascorbate and aldarate metabolism Dopaminergic synapse 0 0 -0.40952381 kegg kegg NA NA no no no no up no Autophagy - animal Dopaminergic synapse 0 -0.614624506 0 kegg kegg NA NA no no no no up no Autophagy - other Dopaminergic synapse 0 -0.435770751 0 kegg kegg NA NA no no no no up no Axon guidance Dopaminergic synapse 0.429565217 0 0 kegg kegg NA NA no up up no up no B cell receptor signaling pathway Dopaminergic synapse 0 -0.622529644 0 kegg kegg NA NA no no no no up no beta-Alanine metabolism Dopaminergic synapse -0.76173913 0 -0.506563707 kegg kegg NA NA no no no no up no Biosynthesis of amino acids Dopaminergic synapse -0.684347826 -0.550395257 -0.583011583 kegg kegg NA NA no no no no up no Biosynthesis of cofactors Dopaminergic synapse 0 0.5 0 kegg kegg NA NA no no no no up no Blautia Dopaminergic synapse 0 -0.416996047 0 acetate-producing Genus kegg 1.36E-05 NA up dn dn no up no Butanoate metabolism Dopaminergic synapse -0.611304348 0 0 kegg kegg NA NA no no no no up no Butyricimonas Dopaminergic synapse 0.476400418 0 0 butyrate-producing Genus kegg 0.17 NA no no no no up no C-type lectin receptor signaling pathway Dopaminergic synapse 0 -0.73715415 0 kegg kegg NA NA no no no no up no Calcium signaling pathway Dopaminergic synapse 0.688695652 0.666007905 0.738481338 kegg kegg NA NA no up up no up no cAMP signaling pathway Dopaminergic synapse 0.81826087 0 0.60952381 yes kegg kegg NA NA no up up no up no Carbon metabolism Dopaminergic synapse -0.653043478 0 -0.654311454 kegg kegg NA NA no no no no up no Cardiac muscle contraction Dopaminergic synapse 0.626086957 0.664031621 0 kegg kegg NA NA no no up no up no Cell adhesion molecules Dopaminergic synapse -0.500869565 -0.604743083 0 kegg kegg NA NA no no no no up no Cellular senescence Dopaminergic synapse 0 -0.583003953 0 kegg kegg NA NA no no no no up no cGMP-PKG signaling pathway Dopaminergic synapse 0 -0.461462451 0 kegg kegg NA NA no no no no up no Circadian entrainment Dopaminergic synapse 0.731304348 0.861660079 0.723294723 kegg kegg NA NA no up up no up no Circadian rhythm Dopaminergic synapse 0.60173913 0 0 kegg kegg NA NA no no no no up no Citrate cycle (TCA cycle) Dopaminergic synapse -0.42 0 0 kegg kegg NA NA no no no no up no Complement and coagulation cascades Dopaminergic synapse -0.503478261 -0.428853755 0 kegg kegg NA NA no no no no up no Coprococcus Dopaminergic synapse 0 0 -0.559238047 butyrate-producing Genus kegg 0.612 NA no no no no up no Drug metabolism - cytochrome P450 Dopaminergic synapse 0 0.449604743 0 kegg kegg NA NA no no no no up no Drug metabolism - other enzymes Dopaminergic synapse -0.56173913 0.437747036 0 kegg kegg NA NA no no no no up no ECM-receptor interaction Dopaminergic synapse 0 0 0.509137709 kegg kegg NA NA no up up no up no EGFR tyrosine kinase inhibitor resistance Dopaminergic synapse 0 0.467391304 0 kegg kegg NA NA no no no no up no Endocrine resistance Dopaminergic synapse 0.61826087 0.468379447 0.615958816 kegg kegg NA NA no no no no up no Endocytosis Dopaminergic synapse 0 -0.565217391 0 kegg kegg NA NA no no no no up no Ether lipid metabolism Dopaminergic synapse 0.416521739 0.464426877 0 kegg kegg NA NA no no no no up no Fatty acid biosynthesis Dopaminergic synapse 0 -0.614624506 -0.437323037 kegg kegg NA NA no no no no up no Fatty acid degradation Dopaminergic synapse -0.622608696 -0.636363636 -0.674903475 kegg kegg NA NA no no no no up no Fatty acid elongation Dopaminergic synapse -0.551304348 0 0 kegg kegg NA NA no no no no up no Fatty acid metabolism Dopaminergic synapse -0.680869565 -0.556324111 -0.572458172 kegg kegg NA NA no no no no up no Fc epsilon RI signaling pathway Dopaminergic synapse 0 -0.617588933 0 kegg kegg NA NA no no no no up no Fc gamma R-mediated phagocytosis Dopaminergic synapse -0.475652174 -0.539525692 -0.437837838 kegg kegg NA NA no no no no up no Ferroptosis Dopaminergic synapse 0.488695652 0 0 kegg kegg NA NA no no no no up no Focal adhesion Dopaminergic synapse 0 0.442687747 0 kegg kegg NA NA no up up no up no FoxO signaling pathway Dopaminergic synapse 0 -0.539525692 0 kegg kegg NA NA no no no no up no Fructose and mannose metabolism Dopaminergic synapse -0.70173913 -0.418972332 -0.62007722 kegg kegg NA NA no no no no up no Galactose metabolism Dopaminergic synapse -0.78173913 -0.675889328 -0.535649936 kegg kegg NA NA no no no no up no Gap junction Dopaminergic synapse 0.449565217 0.415019763 0 kegg kegg NA NA no no no no up no Glutamatergic synapse Dopaminergic synapse 0.530434783 0 0 kegg kegg NA NA no up up no up no Glutathione metabolism Dopaminergic synapse 0 0.755928854 0 kegg kegg NA NA no no no no up no Glycerolipid metabolism Dopaminergic synapse -0.606956522 0 0 kegg kegg NA NA no no up no up no "Glycine, serine and threonine metabolism" Dopaminergic synapse 0 0.455533597 0 kegg kegg NA NA no up no no up no Glycolysis / Gluconeogenesis Dopaminergic synapse -0.547826087 0 -0.428571429 kegg kegg NA NA no no no no up no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Dopaminergic synapse 0 -0.526679842 0 kegg kegg NA NA no no no no up no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Dopaminergic synapse -0.439130435 0 0 kegg kegg NA NA no no no no up no Glyoxylate and dicarboxylate metabolism Dopaminergic synapse -0.62 -0.581027668 -0.516859717 kegg kegg NA NA no no no no up no Hematopoietic cell lineage Dopaminergic synapse -0.43826087 0 0 kegg kegg NA NA no no no no up no Hippo signaling pathway Dopaminergic synapse 0 0.483201581 0 kegg kegg NA NA no no no no up no Hippo signaling pathway - multiple species Dopaminergic synapse 0 -0.507905138 0 kegg kegg NA NA no no no no up no Histidine metabolism Dopaminergic synapse -0.617391304 0 -0.657400257 kegg kegg NA NA no no no no up no IL-17 signaling pathway Dopaminergic synapse 0 -0.489130435 0 kegg kegg NA NA no no no no up no Inositol phosphate metabolism Dopaminergic synapse -0.466956522 0 0 kegg kegg NA NA no no no no up no JAK-STAT signaling pathway Dopaminergic synapse 0 -0.643280632 0 kegg kegg NA NA no no no no up no Long-term potentiation Dopaminergic synapse 0.572173913 0 0.47001287 kegg kegg NA NA no no up no up no Lysosome Dopaminergic synapse 0 0 -0.523809524 kegg kegg NA NA no no no no up no MAPK signaling pathway Dopaminergic synapse 0 -0.507905138 0 kegg kegg NA NA no no no no up no Mitophagy - animal Dopaminergic synapse 0.626086957 0.527667984 0 kegg kegg NA NA no no no no up no mRNA surveillance pathway Dopaminergic synapse 0.562608696 0.464426877 0.44041184 kegg kegg NA NA no no no no up no mTOR signaling pathway Dopaminergic synapse 0 0.448616601 0 kegg kegg NA NA no no no no up no N-Glycan biosynthesis Dopaminergic synapse 0 0.46541502 0 kegg kegg NA NA no no no no up no Natural killer cell mediated cytotoxicity Dopaminergic synapse 0 -0.564229249 0 kegg kegg NA NA no no no no up no Necroptosis Dopaminergic synapse 0.573043478 0 0 kegg kegg NA NA no no no no up no Neuroactive ligand-receptor interaction Dopaminergic synapse 0 -0.441699605 -0.423166023 kegg kegg NA NA up up up no up no Neurotrophin signaling pathway Dopaminergic synapse 0 -0.580039526 0 kegg kegg NA NA no no no no up no Neutrophil extracellular trap formation Dopaminergic synapse -0.484347826 0 -0.410810811 kegg kegg NA NA no no no no up no NF-kappa B signaling pathway Dopaminergic synapse -0.433043478 -0.634387352 0 kegg kegg NA NA no no no no up no Nicotinate and nicotinamide metabolism Dopaminergic synapse 0 -0.503952569 -0.47979408 kegg kegg NA NA no no no no up no NOD-like receptor signaling pathway Dopaminergic synapse -0.437391304 -0.811264822 0 kegg kegg NA NA no no no no up no Non-homologous end-joining Dopaminergic synapse -0.535652174 0 0 kegg kegg NA NA no no no no up no One carbon pool by folate Dopaminergic synapse 0 0.416996047 0 kegg kegg NA NA no no no no up no Oocyte meiosis Dopaminergic synapse 0.466956522 0 0.451994852 kegg kegg NA NA no no no no up no Oscillospira Dopaminergic synapse 0 -0.425889328 0 LPS-producing Genus kegg 0.62 NA no no no no up no Osteoclast differentiation Dopaminergic synapse -0.45826087 -0.736166008 0 kegg kegg NA NA no no no no up no Other glycan degradation Dopaminergic synapse -0.542608696 -0.480237154 0 kegg kegg NA NA no no no no up no Oxidative phosphorylation Dopaminergic synapse 0.633043478 0.709486166 0 kegg kegg NA NA no no no no up no Pantothenate and CoA biosynthesis Dopaminergic synapse 0 -0.556324111 -0.657400257 kegg kegg NA NA no no dn no up no Pentose phosphate pathway Dopaminergic synapse -0.539130435 -0.436758893 -0.57039897 kegg kegg NA NA no no no no up no Peroxisome Dopaminergic synapse -0.546956522 -0.666007905 -0.571171171 kegg kegg NA NA no no no no up no Phagosome Dopaminergic synapse -0.483478261 -0.522727273 0 kegg kegg NA NA no no no no up no Phenylalanine metabolism Dopaminergic synapse -0.408695652 0 -0.403861004 kegg kegg NA NA no no no no up no Phosphatidylinositol signaling system Dopaminergic synapse 0.434782609 0 0 kegg kegg NA NA no no no no up no Platelet activation Dopaminergic synapse 0 0.572134387 0 kegg kegg NA NA no no no no up no PPAR signaling pathway Dopaminergic synapse 0 -0.688735178 0 kegg kegg NA NA no no no no up no Prevotella Dopaminergic synapse 0 0 0.411800663 acetate-producing Genus kegg 0.287 NA no no no no up no Primary bile acid biosynthesis Dopaminergic synapse -0.405217391 0 0 kegg kegg NA NA no no no no up no Protein export Dopaminergic synapse 0.506086957 0.501976285 0 kegg kegg NA NA no no no no up no Protein processing in endoplasmic reticulum Dopaminergic synapse 0 0.500988142 0 kegg kegg NA NA no no no no up no Pyrimidine metabolism Dopaminergic synapse -0.579130435 0.483201581 0 kegg kegg NA NA no no no no up no Pyruvate metabolism Dopaminergic synapse 0 0.441699605 0 kegg kegg NA NA no no no no up no Rap1 signaling pathway Dopaminergic synapse 0 0.415019763 0 kegg kegg NA NA no no no no up no Ras signaling pathway Dopaminergic synapse 0 0.601778656 0.414157014 yes kegg kegg NA NA no up up no up no Renin-angiotensin system Dopaminergic synapse 0 -0.524703557 -0.422136422 kegg kegg NA NA no no no no up no Retrograde endocannabinoid signaling Dopaminergic synapse 0.509565217 0.793478261 0 kegg kegg NA NA no no up no up no Ribosome Dopaminergic synapse 0.537391304 0.610671937 0 kegg kegg NA NA no no no no up no RIG-I-like receptor signaling pathway Dopaminergic synapse 0 -0.647233202 0 kegg kegg NA NA no no no no up no RNA degradation Dopaminergic synapse 0.485217391 0.476284585 0 kegg kegg NA NA no no no no up no Ruminococcus Dopaminergic synapse 0.413913043 0 0 acetate-producing Genus kegg 0.335 NA no no no no up no Sarcina Dopaminergic synapse 0 -0.466781936 0 Genus kegg 0.0703 NA no no no no up no Serotonergic synapse Dopaminergic synapse 0.602608696 0.418972332 0 kegg kegg NA NA no no no no up no SNARE interactions in vesicular transport Dopaminergic synapse -0.446086957 -0.542490119 0 kegg kegg NA NA no no no no up no Sphingolipid signaling pathway Dopaminergic synapse 0 -0.472332016 0 kegg kegg NA NA no no no no up no Starch and sucrose metabolism Dopaminergic synapse -0.535652174 -0.623517787 -0.6 kegg kegg NA NA no no no no up no Steroid biosynthesis Dopaminergic synapse 0.437391304 0 0 kegg kegg NA NA no no no no up no Synaptic vesicle cycle Dopaminergic synapse 0 0 -0.544916345 kegg kegg NA NA no up up no up no T cell receptor signaling pathway Dopaminergic synapse 0 -0.703557312 0 kegg kegg NA NA no no no no up no TGF-beta signaling pathway Dopaminergic synapse 0.440869565 0.522727273 0 kegg kegg NA NA no no no no up no Th1 and Th2 cell differentiation Dopaminergic synapse 0 -0.740118577 0 kegg kegg NA NA no no no no up no Th17 cell differentiation Dopaminergic synapse 0 -0.793478261 0 kegg kegg NA NA no no no no up no Thermogenesis Dopaminergic synapse 0.635652174 0.711462451 0 kegg kegg NA NA no no no no up no Thiamine metabolism Dopaminergic synapse 0 0.416996047 0 kegg kegg NA NA no no no no up no Tight junction Dopaminergic synapse 0 0.436758893 0 kegg kegg NA NA no no no no up no TNF signaling pathway Dopaminergic synapse 0 -0.606719368 0 kegg kegg NA NA no no no no up no Toll-like receptor signaling pathway Dopaminergic synapse 0 -0.653162055 0 yes kegg kegg NA NA no no no no up no Tryptophan metabolism Dopaminergic synapse -0.645217391 0 0 kegg kegg NA NA no up no no up no Tyrosine metabolism Dopaminergic synapse 0 0.441699605 0 kegg kegg NA NA no no no no up no Ubiquinone and other terpenoid-quinone biosynthesis Dopaminergic synapse -0.483478261 0 0 kegg kegg NA NA no no no no up no Ubiquitin mediated proteolysis Dopaminergic synapse 0.61826087 0.564229249 0 kegg kegg NA NA no no no no up no "Valine, leucine and isoleucine degradation" Dopaminergic synapse -0.524347826 0 0 kegg kegg NA NA no no no no up no Vascular smooth muscle contraction Dopaminergic synapse 0.77826087 0.833003953 0.766280566 kegg kegg NA NA no no no no up no Wnt signaling pathway Dopaminergic synapse 0.435652174 0.505928854 0 kegg kegg NA NA no no no no up no Blautia Dorea 0 0.505607775 0 acetate-producing Genus Genus 1.36E-05 0.00362 up dn dn up no dn 12-ketoDCA+blood DPA+blood -0.451717371 0 0 serum_bileacids serum_ARA 0.517 0.519 no no no no no no "12,13-EPOME+blood" DPA+blood 0 0 0.415212596 serum_ARA serum_ARA 0.901 0.519 no no no no no no 14:0-LPC+blood DPA+blood 0.446616541 0 0 serum_phospholipids serum_ARA 0.00689 0.519 up up no no no no 14:0/18:2-PC+blood DPA+blood 0.467669173 0 0 serum_phospholipids serum_ARA 0.102 0.519 no up no no no no 14:0+blood DPA+blood 0.62406015 0 0 yes serum_fattyacid serum_ARA 0.00572 0.519 up no dn no no no 16:0-LPC+blood DPA+blood 0.607518797 0 0 serum_phospholipids serum_ARA 0.00456 0.519 up up no no no no 16:0/18:0-PC+blood DPA+blood 0 0 -0.422905983 serum_phospholipids serum_ARA 0.521 0.519 no no no no no no 16:0/18:2-PI+blood DPA+blood 0.455639098 0 0 serum_phospholipids serum_ARA 0.269 0.519 no no no no no no 16:0/20:5-PG+blood DPA+blood -0.466165414 0 0 serum_phospholipids serum_ARA 0.00656 0.519 no up no no no no 16:0+blood DPA+blood 0.446616541 0 0 yes serum_fattyacid serum_ARA 0.00876 0.519 up no no no no no 16:1/16:1-PC+blood DPA+blood 0 0 -0.438632479 serum_phospholipids serum_ARA 0.0177 0.519 no no up no no no 18:0-LPC+blood DPA+blood 0.497744361 0 0 serum_phospholipids serum_ARA 0.554 0.519 no no no no no no 18:0-LPE+blood DPA+blood 0 -0.482843137 0 serum_phospholipids serum_ARA 0.491 0.519 no no no no no no 18:0/18:1-PI+blood DPA+blood 0 0 0.455042735 serum_phospholipids serum_ARA 0.599 0.519 no no no no no no 18:0/22:6-PI+blood DPA+blood 0.542857143 0 0 serum_phospholipids serum_ARA 0.425 0.519 no no no no no no 18:2/16:0-PC+blood DPA+blood 0 0 -0.483076923 serum_phospholipids serum_ARA 8.67E-05 0.519 no up up no no no 18:2n6c+blood DPA+blood 0.606015038 0 -0.467350427 serum_fattyacid serum_ARA 0.15 0.519 no no no no no no 20:2/18:3-PE+blood DPA+blood -0.506766917 0 0 serum_phospholipids serum_ARA 0.0391 0.519 up up no no no no 20:2+blood DPA+blood 0.523308271 0 0 serum_fattyacid serum_ARA 0.478 0.519 no no no no no no 22:6-LPC+blood DPA+blood 0.612030075 0 0 serum_phospholipids serum_ARA 0.127 0.519 no no up no no no Adipocytokine signaling pathway DPA+blood -0.545614035 0 0 kegg serum_ARA NA 0.519 no no no no no no Adrenergic signaling in cardiomyocytes DPA+blood 0 -0.644117647 0 kegg serum_ARA NA 0.519 no no up no no no Aldosterone synthesis and secretion DPA+blood 0 -0.567647059 0 kegg serum_ARA NA 0.519 no up up no no no Allograft rejection DPA+blood 0 0.747058824 0 kegg serum_ARA NA 0.519 no no no no no no Amphetamine addiction DPA+blood 0 -0.647058824 0 kegg serum_ARA NA 0.519 no no no no no no AMPK signaling pathway DPA+blood 0 -0.520588235 0 kegg serum_ARA NA 0.519 no no no no no no Amyotrophic lateral sclerosis DPA+blood 0 -0.5 0 kegg serum_ARA NA 0.519 no no no no no no Apoptosis DPA+blood 0 0.6 0 kegg serum_ARA NA 0.519 no no no no no no Autoimmune thyroid disease DPA+blood 0 0.747058824 0 kegg serum_ARA NA 0.519 no no no no no no Biosynthesis of cofactors DPA+blood 0 -0.661764706 0 kegg serum_ARA NA 0.519 no no no no no no C-type lectin receptor signaling pathway DPA+blood 0 0.526470588 0 kegg serum_ARA NA 0.519 no no no no no no Cell adhesion molecules DPA+blood 0 0.764705882 0 kegg serum_ARA NA 0.519 no no no no no no Cellular senescence DPA+blood 0 0.741176471 0 kegg serum_ARA NA 0.519 no no no no no no Circadian entrainment DPA+blood 0 -0.597058824 0 kegg serum_ARA NA 0.519 no up up no no no Clostridium DPA+blood 0.500188076 0 0 Genus serum_ARA 0.925 0.519 no no no no no no Cushing syndrome DPA+blood 0 -0.514705882 0 kegg serum_ARA NA 0.519 no no up no no no d18:1-14:1-SM+blood DPA+blood 0 -0.507352941 0 serum_phospholipids serum_ARA 0.0952 0.519 no dn no no no no d18:1-24:1-SM+blood DPA+blood -0.494736842 0 0 serum_phospholipids serum_ARA 0.0123 0.519 no dn dn no no no DHA+blood DPA+blood 0.503759398 0.539215686 0.441367521 serum_ARA serum_ARA 0.872 0.519 no no no no no no Dopaminergic synapse DPA+blood 0 -0.776470588 0 kegg serum_ARA NA 0.519 no up no no no no Endocytosis DPA+blood 0 0.732352941 0 kegg serum_ARA NA 0.519 no no no no no no Estrogen signaling pathway DPA+blood 0.487719298 0 0 kegg serum_ARA NA 0.519 no no no no no no Fc epsilon RI signaling pathway DPA+blood 0 0.558823529 0 kegg serum_ARA NA 0.519 no no no no no no Fc gamma R-mediated phagocytosis DPA+blood 0 0.502941176 0 kegg serum_ARA NA 0.519 no no no no no no GABAergic synapse DPA+blood 0 0 -0.453076923 kegg serum_ARA NA 0.519 no up up no no no GCA+stool DPA+blood 0 0.645454545 0 stool_bileacids serum_ARA 0.0809 0.519 no no no no no no Glucagon signaling pathway DPA+blood 0 -0.523529412 0 kegg serum_ARA NA 0.519 no no no no no no Glutamatergic synapse DPA+blood 0 0 -0.444615385 kegg serum_ARA NA 0.519 no up up no no no "Glycine, serine and threonine metabolism" DPA+blood 0 -0.597058824 0 kegg serum_ARA NA 0.519 no up no no no no Graft-versus-host disease DPA+blood 0 0.747058824 0 kegg serum_ARA NA 0.519 no no no no no no Human papillomavirus infection DPA+blood 0 0.726470588 0.411538462 kegg serum_ARA NA 0.519 no no no no no no Inflammatory mediator regulation of TRP channels DPA+blood 0.464912281 0 0 kegg serum_ARA NA 0.519 no no no no no no Insulin signaling pathway DPA+blood 0 -0.520588235 0 kegg serum_ARA NA 0.519 no no no no no no JAK-STAT signaling pathway DPA+blood 0 0.5 0 kegg serum_ARA NA 0.519 no no no no no no Lipid and atherosclerosis DPA+blood 0 0.664705882 0 kegg serum_ARA NA 0.519 no no no no no no Long-term potentiation DPA+blood 0.568421053 0 0 kegg serum_ARA NA 0.519 no no up no no no Malaria DPA+blood 0 0 -0.431538462 kegg serum_ARA NA 0.519 no no no no no no Measles DPA+blood 0 0 0.411538462 kegg serum_ARA NA 0.519 no no no no no no Mineral absorption DPA+blood 0 -0.570588235 0 kegg serum_ARA NA 0.519 no no no no no no Morphine addiction DPA+blood 0 -0.561764706 0 kegg serum_ARA NA 0.519 no up up no no no mTOR signaling pathway DPA+blood 0 -0.526470588 0 kegg serum_ARA NA 0.519 no no no no no no Natural killer cell mediated cytotoxicity DPA+blood 0 0.767647059 0 kegg serum_ARA NA 0.519 no no no no no no NOD-like receptor signaling pathway DPA+blood 0 0.626470588 0 kegg serum_ARA NA 0.519 no no no no no no Osteoclast differentiation DPA+blood 0 0.641176471 0 kegg serum_ARA NA 0.519 no no no no no no Pancreatic secretion DPA+blood 0 -0.647058824 0 kegg serum_ARA NA 0.519 no no no no no no "Parathyroid hormone synthesis, secretion and action" DPA+blood 0 -0.544117647 0 kegg serum_ARA NA 0.519 no no no no no no Pathogenic Escherichia coli infection DPA+blood 0 0.511764706 0 kegg serum_ARA NA 0.519 no no no no no no Pathways of neurodegeneration - multiple diseases DPA+blood 0 0 -0.408461538 kegg serum_ARA NA 0.519 no no no no no no Phagosome DPA+blood 0 0.673529412 0 kegg serum_ARA NA 0.519 no no no no no no Porphyrin and chlorophyll metabolism DPA+blood 0 -0.641176471 0 kegg serum_ARA NA 0.519 no no no no no no Prolactin signaling pathway DPA+blood 0 0.502941176 0 kegg serum_ARA NA 0.519 no no no no no no Purine metabolism DPA+blood 0 -0.644117647 0 kegg serum_ARA NA 0.519 no no no no no no Renin secretion DPA+blood 0 -0.594117647 0 kegg serum_ARA NA 0.519 no no no no no no Retrograde endocannabinoid signaling DPA+blood 0 -0.505882353 0 kegg serum_ARA NA 0.519 no no up no no no Rheumatoid arthritis DPA+blood 0 0.535294118 0 kegg serum_ARA NA 0.519 no no no no no no Sphingolipid signaling pathway DPA+blood 0 0.526470588 0 kegg serum_ARA NA 0.519 no no no no no no Staphylococcus aureus infection DPA+blood 0 0.520588235 0 kegg serum_ARA NA 0.519 up no no no no no Th1 and Th2 cell differentiation DPA+blood 0 0.567647059 0 kegg serum_ARA NA 0.519 no no no no no no Th17 cell differentiation DPA+blood 0 0.544117647 0 kegg serum_ARA NA 0.519 no no no no no no Thyroid hormone synthesis DPA+blood 0 -0.605882353 0 kegg serum_ARA NA 0.519 no no no no no no Toxoplasmosis DPA+blood 0 0.532352941 0 kegg serum_ARA NA 0.519 no no no no no no Tuberculosis DPA+blood 0 0.520588235 0 kegg serum_ARA NA 0.519 no no dn no no no Type I diabetes mellitus DPA+blood 0 0.747058824 0 kegg serum_ARA NA 0.519 no no no no no no Vascular smooth muscle contraction DPA+blood 0 -0.602941176 -0.446153846 kegg serum_ARA NA 0.519 no no no no no no Viral carcinogenesis DPA+blood 0 0.764705882 0 kegg serum_ARA NA 0.519 no no no no no no Viral myocarditis DPA+blood 0 0.661764706 0 kegg serum_ARA NA 0.519 no no no no no no "Alanine, aspartate and glutamate metabolism" Drug metabolism - cytochrome P450 0 -0.717391304 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Drug metabolism - cytochrome P450 0.433913043 0 0.495752896 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Drug metabolism - cytochrome P450 0.490434783 0 0.447619048 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Drug metabolism - cytochrome P450 0 0.652173913 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Drug metabolism - cytochrome P450 0.484347826 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Drug metabolism - cytochrome P450 0 -0.685770751 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Drug metabolism - cytochrome P450 0 -0.740118577 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Drug metabolism - cytochrome P450 0 0.653162055 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Drug metabolism - cytochrome P450 0 0.668972332 0.535135135 kegg kegg NA NA no no no no no no Butanoate metabolism Drug metabolism - cytochrome P450 0 0.877470356 0.480566281 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Drug metabolism - cytochrome P450 0.489565217 0.91798419 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Drug metabolism - cytochrome P450 0.590434783 0.812252964 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Drug metabolism - cytochrome P450 0 -0.726284585 0 kegg kegg NA NA no no no no no no Fatty acid elongation Drug metabolism - cytochrome P450 0 0.589920949 0.566537967 kegg kegg NA NA no no no no no no Folate biosynthesis Drug metabolism - cytochrome P450 0 0.480237154 0 kegg kegg NA NA no no no no no no Glutathione metabolism Drug metabolism - cytochrome P450 0.474782609 0.558300395 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Drug metabolism - cytochrome P450 -0.434782609 0 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Drug metabolism - cytochrome P450 0.575652174 0.72826087 0.492406692 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Drug metabolism - cytochrome P450 0 -0.778656126 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Drug metabolism - cytochrome P450 0 0.546442688 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Drug metabolism - cytochrome P450 -0.588695652 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Drug metabolism - cytochrome P450 0 0.580039526 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Drug metabolism - cytochrome P450 0.504347826 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Drug metabolism - cytochrome P450 -0.671304348 -0.418972332 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Drug metabolism - cytochrome P450 0 -0.732213439 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Drug metabolism - cytochrome P450 0.635652174 0.440711462 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Drug metabolism - cytochrome P450 -0.59826087 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 0.973913043 0.97826087 0.984298584 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Drug metabolism - cytochrome P450 0.530434783 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Drug metabolism - cytochrome P450 0 0.783596838 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Drug metabolism - cytochrome P450 0 -0.763833992 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Drug metabolism - cytochrome P450 0 -0.750988142 0 kegg kegg NA NA no no no no no no One carbon pool by folate Drug metabolism - cytochrome P450 0 0.76284585 0 kegg kegg NA NA no no no no no no Other glycan degradation Drug metabolism - cytochrome P450 0 0 0.455341055 kegg kegg NA NA no no no no no no Oxidative phosphorylation Drug metabolism - cytochrome P450 0 0.486166008 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Drug metabolism - cytochrome P450 0 -0.593873518 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Drug metabolism - cytochrome P450 0.703478261 0.878458498 0.548777349 kegg kegg NA NA no no no no no no Pentose phosphate pathway Drug metabolism - cytochrome P450 0 -0.483201581 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Drug metabolism - cytochrome P450 0 0.858695652 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Drug metabolism - cytochrome P450 0.472173913 0.567193676 0.454054054 kegg kegg NA NA no no no no no no Propanoate metabolism Drug metabolism - cytochrome P450 0.611304348 0.777667984 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Drug metabolism - cytochrome P450 0.426956522 0.72826087 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Drug metabolism - cytochrome P450 0.534782609 0.833003953 0 kegg kegg NA NA no no no no no no Retinol metabolism Drug metabolism - cytochrome P450 0.637391304 0.658102767 0.501673102 kegg kegg NA NA no no no no no no Sphingolipid metabolism Drug metabolism - cytochrome P450 0 0 0.439382239 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Drug metabolism - cytochrome P450 0 -0.576086957 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Drug metabolism - cytochrome P450 0 0.678853755 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Drug metabolism - cytochrome P450 0.617391304 0.727272727 0 kegg kegg NA NA no no no no no no Sulfur metabolism Drug metabolism - cytochrome P450 0 0.433794466 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Drug metabolism - cytochrome P450 0 0.687747036 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Drug metabolism - cytochrome P450 0 -0.449604743 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Drug metabolism - cytochrome P450 0 0.437747036 0 kegg kegg NA NA no no no no no no Thiamine metabolism Drug metabolism - cytochrome P450 0 0.625494071 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Drug metabolism - cytochrome P450 0 0.779644269 0.426512227 kegg kegg NA NA no up no no no no Tyrosine metabolism Drug metabolism - cytochrome P450 0.587826087 0.841897233 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Drug metabolism - cytochrome P450 0.406956522 0.78458498 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Drug metabolism - cytochrome P450 0.432173913 0.868577075 0.513770914 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Drug metabolism - cytochrome P450 0 0.656126482 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Drug metabolism - other enzymes 0 -0.814229249 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Drug metabolism - other enzymes 0.705217391 -0.480237154 0.507335907 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Drug metabolism - other enzymes 0.740869565 0 0.407207207 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Drug metabolism - other enzymes 0.54 0.450592885 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Drug metabolism - other enzymes 0.569565217 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Drug metabolism - other enzymes 0 -0.696640316 0.414929215 kegg kegg NA NA no up no no no no Arginine biosynthesis Drug metabolism - other enzymes 0 -0.794466403 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Drug metabolism - other enzymes 0.433913043 0.553359684 0.564993565 kegg kegg NA NA no no no no no no beta-Alanine metabolism Drug metabolism - other enzymes 0.82173913 0.603754941 0 kegg kegg NA NA no no no no no no Butanoate metabolism Drug metabolism - other enzymes 0.767826087 0.822134387 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Drug metabolism - other enzymes 0.711304348 0.856719368 0.42033462 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Drug metabolism - other enzymes 0.434782609 0.757905138 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Drug metabolism - other enzymes 0.606956522 0.89229249 0.602574003 kegg kegg NA NA no no no no no no Ether lipid metabolism Drug metabolism - other enzymes -0.426086957 0 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Drug metabolism - other enzymes 0 -0.805335968 0 kegg kegg NA NA no no no no no no Fatty acid degradation Drug metabolism - other enzymes 0.496521739 -0.529644269 0.413899614 kegg kegg NA NA no no no no no no Fatty acid elongation Drug metabolism - other enzymes 0.708695652 0.586956522 0 kegg kegg NA NA no no no no no no Folate biosynthesis Drug metabolism - other enzymes 0 0.58201581 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Drug metabolism - other enzymes 0.686956522 -0.415019763 0.566537967 kegg kegg NA NA no no no no no no Galactose metabolism Drug metabolism - other enzymes 0.649565217 -0.46541502 0.601287001 kegg kegg NA NA no no no no no no Glutathione metabolism Drug metabolism - other enzymes 0.448695652 0.585968379 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Drug metabolism - other enzymes 0 -0.555335968 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Drug metabolism - other enzymes 0 -0.513833992 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Drug metabolism - other enzymes 0.835652174 0.792490119 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Drug metabolism - other enzymes 0 -0.840909091 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Drug metabolism - other enzymes 0.633043478 0.53458498 0.436808237 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Drug metabolism - other enzymes -0.533913043 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Drug metabolism - other enzymes 0 0 0.547747748 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Drug metabolism - other enzymes 0 0.484189723 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Drug metabolism - other enzymes -0.562608696 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Drug metabolism - other enzymes 0 -0.769762846 0 kegg kegg NA NA no no no no no no Histidine metabolism Drug metabolism - other enzymes 0.599130435 0 0.431660232 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Drug metabolism - other enzymes 0 -0.419960474 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Drug metabolism - other enzymes 0.548695652 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Drug metabolism - other enzymes -0.611304348 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Drug metabolism - other enzymes 0.736521739 0.908102767 0.574517375 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Drug metabolism - other enzymes 0.48 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Drug metabolism - other enzymes 0 0.72826087 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Drug metabolism - other enzymes 0 -0.811264822 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Drug metabolism - other enzymes 0 -0.751976285 0 kegg kegg NA NA no no no no no no One carbon pool by folate Drug metabolism - other enzymes 0 0.599802372 0 kegg kegg NA NA no no no no no no Other glycan degradation Drug metabolism - other enzymes 0 0 0.531788932 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Drug metabolism - other enzymes -0.446956522 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Drug metabolism - other enzymes -0.534782609 0.557312253 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Drug metabolism - other enzymes 0 -0.643280632 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Drug metabolism - other enzymes 0.605217391 0.850790514 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Drug metabolism - other enzymes 0.672173913 0.764822134 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Drug metabolism - other enzymes 0.629565217 0.592885375 0 kegg kegg NA NA no no no no no no Propanoate metabolism Drug metabolism - other enzymes 0.57826087 0.720355731 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Drug metabolism - other enzymes 0.831304348 0.707509881 0.697812098 kegg kegg NA NA no no no no no no Pyruvate metabolism Drug metabolism - other enzymes 0.546956522 0.786561265 0 kegg kegg NA NA no no no no no no Retinol metabolism Drug metabolism - other enzymes 0.688695652 0.467391304 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Drug metabolism - other enzymes 0 0 0.618790219 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Drug metabolism - other enzymes 0.477391304 -0.651185771 0.595624196 kegg kegg NA NA no no no no no no Steroid biosynthesis Drug metabolism - other enzymes 0 0.559288538 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Drug metabolism - other enzymes 0.604347826 0.595849802 0.442471042 kegg kegg NA NA no no no no no no Sulfur metabolism Drug metabolism - other enzymes 0.513043478 0.456521739 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Drug metabolism - other enzymes 0.451304348 0.493083004 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Drug metabolism - other enzymes 0 -0.651185771 0 kegg kegg NA NA no no no no no no Thiamine metabolism Drug metabolism - other enzymes 0 0.597826087 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Drug metabolism - other enzymes 0.815652174 0.716403162 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Drug metabolism - other enzymes 0.702608696 0.725296443 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Drug metabolism - other enzymes 0.685217391 0.586956522 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Drug metabolism - other enzymes 0.703478261 0.734189723 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Drug metabolism - other enzymes 0 0.631422925 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes ECM-receptor interaction 0 0 0.611840412 kegg kegg NA NA no no up no up up "Alanine, aspartate and glutamate metabolism" ECM-receptor interaction 0 0 -0.404633205 kegg kegg NA NA no no no no up up Aminoacyl-tRNA biosynthesis ECM-receptor interaction 0.485217391 0 0 kegg kegg NA NA no no no no up up Antifolate resistance ECM-receptor interaction 0 0.532608696 0 kegg kegg NA NA no no no no up up Apelin signaling pathway ECM-receptor interaction 0 0.489130435 0 kegg kegg NA NA no no no no up up Apoptosis ECM-receptor interaction 0 -0.588932806 0 kegg kegg NA NA no no no no up up Arginine and proline metabolism ECM-receptor interaction -0.463478261 0 0 kegg kegg NA NA no up no no up up Axon guidance ECM-receptor interaction 0 0 0.46023166 kegg kegg NA NA no up up no up up Base excision repair ECM-receptor interaction 0.566956522 0.524703557 0 kegg kegg NA NA no no no no up up Biosynthesis of amino acids ECM-receptor interaction 0 0 -0.416473616 kegg kegg NA NA no no no no up up Biosynthesis of cofactors ECM-receptor interaction 0.47826087 0.473320158 0 kegg kegg NA NA no no no no up up Biosynthesis of unsaturated fatty acids ECM-receptor interaction 0.584347826 0.492094862 0 kegg kegg NA NA no no no no up up Butanoate metabolism ECM-receptor interaction 0.471304348 0.568181818 0 kegg kegg NA NA no no no no up up Calcium signaling pathway ECM-receptor interaction 0 0 0.463320463 kegg kegg NA NA no up up no up up cAMP signaling pathway ECM-receptor interaction 0 -0.556324111 0 yes kegg kegg NA NA no up up no up up Cell cycle ECM-receptor interaction 0.527826087 0.522727273 0.404118404 kegg kegg NA NA no no no no up up Cellular senescence ECM-receptor interaction 0 -0.418972332 0 kegg kegg NA NA no no no no up up cGMP-PKG signaling pathway ECM-receptor interaction -0.536521739 0 0 kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) ECM-receptor interaction 0.405217391 0.533596838 0 kegg kegg NA NA no no no no up up Cysteine and methionine metabolism ECM-receptor interaction 0.495652174 0.605731225 0 kegg kegg NA NA no no no no up up DNA replication ECM-receptor interaction 0.524347826 0.508893281 0 kegg kegg NA NA no no no no up up Drug metabolism - cytochrome P450 ECM-receptor interaction 0 0.476284585 0 kegg kegg NA NA no no no no up up Drug metabolism - other enzymes ECM-receptor interaction 0 0.498023715 0 kegg kegg NA NA no no no no up up Fanconi anemia pathway ECM-receptor interaction 0.58 0 0 kegg kegg NA NA no no no no up up Fatty acid degradation ECM-receptor interaction 0 0 -0.483140283 kegg kegg NA NA no no no no up up Fatty acid elongation ECM-receptor interaction 0 0.459486166 0 kegg kegg NA NA no no no no up up Fatty acid metabolism ECM-receptor interaction 0 0 -0.472329472 kegg kegg NA NA no no no no up up Ferroptosis ECM-receptor interaction 0 -0.422924901 0 kegg kegg NA NA no no no no up up Fructose and mannose metabolism ECM-receptor interaction 0 0 -0.404375804 kegg kegg NA NA no no no no up up Glutathione metabolism ECM-receptor interaction 0 0.57312253 0 kegg kegg NA NA no no no no up up "Glycine, serine and threonine metabolism" ECM-receptor interaction 0.46 0 0 kegg kegg NA NA no up no no up up Glycolysis / Gluconeogenesis ECM-receptor interaction 0.46 0.444664032 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate ECM-receptor interaction -0.586956522 -0.416996047 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate ECM-receptor interaction 0 0 0.595624196 kegg kegg NA NA no no no no up up Glycosaminoglycan degradation ECM-receptor interaction -0.624347826 -0.438735178 0 kegg kegg NA NA no no up no up up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis ECM-receptor interaction 0.419130435 0 0 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species ECM-receptor interaction -0.505217391 0 0 kegg kegg NA NA no no no no up up Homologous recombination ECM-receptor interaction 0.603478261 0 0 kegg kegg NA NA no no no no up up Lysosome ECM-receptor interaction -0.735652174 0 -0.507850708 kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 ECM-receptor interaction 0 0.421936759 0 kegg kegg NA NA no no no no up up Mismatch repair ECM-receptor interaction 0.533043478 0.595849802 0 kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis ECM-receptor interaction 0.435652174 0 0 kegg kegg NA NA no no no no up up N-Glycan biosynthesis ECM-receptor interaction 0.612173913 0.488142292 0.482882883 kegg kegg NA NA no no no no up up NF-kappa B signaling pathway ECM-receptor interaction 0 -0.432806324 0 kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism ECM-receptor interaction -0.520869565 -0.463438735 -0.457400257 kegg kegg NA NA no no no no up up Non-homologous end-joining ECM-receptor interaction 0.539130435 0.632411067 0 kegg kegg NA NA no no no no up up Notch signaling pathway ECM-receptor interaction -0.539130435 0 0 kegg kegg NA NA no no no no up up Nucleotide excision repair ECM-receptor interaction 0.568695652 0.561264822 0 kegg kegg NA NA no no no no up up One carbon pool by folate ECM-receptor interaction 0.560869565 0.5 0 kegg kegg NA NA no no no no up up Oocyte meiosis ECM-receptor interaction 0 0.612648221 0.476962677 kegg kegg NA NA no no no no up up Osteoclast differentiation ECM-receptor interaction -0.571304348 -0.434782609 0 kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis ECM-receptor interaction 0 0 -0.478764479 kegg kegg NA NA no no dn no up up Pentose and glucuronate interconversions ECM-receptor interaction 0.45826087 0.442687747 0 kegg kegg NA NA no no no no up up Pentose phosphate pathway ECM-receptor interaction 0 0 -0.500643501 kegg kegg NA NA no no no no up up Peroxisome ECM-receptor interaction 0 0 -0.574517375 kegg kegg NA NA no no no no up up Phenylalanine metabolism ECM-receptor interaction 0 0.425889328 0 kegg kegg NA NA no no no no up up Phospholipase D signaling pathway ECM-receptor interaction 0 -0.522727273 0 kegg kegg NA NA no up up no up up Platinum drug resistance ECM-receptor interaction 0.42 0 0 kegg kegg NA NA no no no no up up Primary bile acid biosynthesis ECM-receptor interaction 0.506086957 0.507905138 0 kegg kegg NA NA no no no no up up Propanoate metabolism ECM-receptor interaction 0.417391304 0.587944664 0 kegg kegg NA NA no no no no up up Protein processing in endoplasmic reticulum ECM-receptor interaction 0.556521739 0.492094862 0 kegg kegg NA NA no no no no up up Pyrimidine metabolism ECM-receptor interaction 0 0.546442688 0 kegg kegg NA NA no no no no up up Pyruvate metabolism ECM-receptor interaction 0.437391304 0.558300395 0 kegg kegg NA NA no no no no up up Ras signaling pathway ECM-receptor interaction 0 0.585968379 0.453539254 yes kegg kegg NA NA no up up no up up Retinol metabolism ECM-receptor interaction 0 0.555335968 0 kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes ECM-receptor interaction 0.526956522 0 0 kegg kegg NA NA no no no no up up RNA polymerase ECM-receptor interaction 0.44173913 0 0 kegg kegg NA NA no no no no up up RNA transport ECM-receptor interaction 0.499130435 0 0 kegg kegg NA NA no no no no up up Sphingolipid metabolism ECM-receptor interaction -0.669565217 0 0 kegg kegg NA NA no no no no up up Sphingolipid signaling pathway ECM-receptor interaction -0.42173913 0 0 kegg kegg NA NA no no no no up up Spliceosome ECM-receptor interaction 0.470434783 0 0 kegg kegg NA NA no no no no up up Starch and sucrose metabolism ECM-receptor interaction 0 0 -0.451737452 kegg kegg NA NA no no no no up up Steroid biosynthesis ECM-receptor interaction 0 0.43972332 0 kegg kegg NA NA no no no no up up Sulfur metabolism ECM-receptor interaction 0 0.548418972 0 kegg kegg NA NA no no no no up up Synthesis and degradation of ketone bodies ECM-receptor interaction 0.427826087 0.552371542 0 kegg kegg NA NA no no no no up up TGF-beta signaling pathway ECM-receptor interaction 0 0.490118577 0.50990991 kegg kegg NA NA no no no no up up Thiamine metabolism ECM-receptor interaction 0 0.593873518 0 kegg kegg NA NA no no no no up up Tryptophan metabolism ECM-receptor interaction 0 0.423913043 0 kegg kegg NA NA no up no no up up Tyrosine metabolism ECM-receptor interaction 0.433043478 0.536561265 0 kegg kegg NA NA no no no no up up Ubiquinone and other terpenoid-quinone biosynthesis ECM-receptor interaction 0 0.502964427 0 kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" ECM-receptor interaction 0.462608696 0.442687747 0 kegg kegg NA NA no no no no up up Various types of N-glycan biosynthesis ECM-receptor interaction 0.487826087 0.566205534 0.403088803 kegg kegg NA NA no no no no up up "Alanine, aspartate and glutamate metabolism" EGFR tyrosine kinase inhibitor resistance 0 -0.590909091 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism EGFR tyrosine kinase inhibitor resistance 0 -0.792490119 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism EGFR tyrosine kinase inhibitor resistance 0 -0.602766798 0 kegg kegg NA NA no up no no no no Arginine biosynthesis EGFR tyrosine kinase inhibitor resistance 0 -0.555335968 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids EGFR tyrosine kinase inhibitor resistance 0 -0.437747036 0 kegg kegg NA NA no no no no no no Butanoate metabolism EGFR tyrosine kinase inhibitor resistance 0 0.53458498 0.592277992 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) EGFR tyrosine kinase inhibitor resistance 0 0.510869565 0.514800515 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism EGFR tyrosine kinase inhibitor resistance 0 0.747035573 0.680566281 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 EGFR tyrosine kinase inhibitor resistance 0 0.542490119 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes EGFR tyrosine kinase inhibitor resistance 0 0.526679842 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis EGFR tyrosine kinase inhibitor resistance 0 -0.602766798 0 kegg kegg NA NA no no no no no no Fatty acid degradation EGFR tyrosine kinase inhibitor resistance 0 -0.480237154 0 kegg kegg NA NA no no no no no no Fatty acid metabolism EGFR tyrosine kinase inhibitor resistance 0 -0.477272727 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism EGFR tyrosine kinase inhibitor resistance 0 -0.609683794 0 kegg kegg NA NA no no no no no no Galactose metabolism EGFR tyrosine kinase inhibitor resistance 0 -0.662055336 0 kegg kegg NA NA no no no no no no Glutathione metabolism EGFR tyrosine kinase inhibitor resistance 0 0.645256917 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism EGFR tyrosine kinase inhibitor resistance 0 -0.566205534 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism EGFR tyrosine kinase inhibitor resistance 0 -0.456521739 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis EGFR tyrosine kinase inhibitor resistance 0 0.639328063 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate EGFR tyrosine kinase inhibitor resistance 0 -0.66798419 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation EGFR tyrosine kinase inhibitor resistance -0.428695652 -0.610671937 0 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism EGFR tyrosine kinase inhibitor resistance 0 -0.518774704 0 kegg kegg NA NA no no no no no no Lysine degradation EGFR tyrosine kinase inhibitor resistance 0.76173913 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis EGFR tyrosine kinase inhibitor resistance 0.510434783 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 EGFR tyrosine kinase inhibitor resistance 0 0.4743083 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis EGFR tyrosine kinase inhibitor resistance 0.415652174 0.587944664 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism EGFR tyrosine kinase inhibitor resistance 0 -0.664031621 0 kegg kegg NA NA no no no no no no Nitrogen metabolism EGFR tyrosine kinase inhibitor resistance 0 -0.494071146 0 kegg kegg NA NA no no no no no no Other glycan degradation EGFR tyrosine kinase inhibitor resistance 0 -0.524703557 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis EGFR tyrosine kinase inhibitor resistance 0.539130435 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation EGFR tyrosine kinase inhibitor resistance 0 0.666007905 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis EGFR tyrosine kinase inhibitor resistance -0.435652174 -0.705533597 0 kegg kegg NA NA no no dn no no no Parabacteroides EGFR tyrosine kinase inhibitor resistance 0 0 -0.449707189 Genus kegg 4.19E-05 NA no up up no no no Pentose and glucuronate interconversions EGFR tyrosine kinase inhibitor resistance 0 0.526679842 0.449420849 kegg kegg NA NA no no no no no no Pentose phosphate pathway EGFR tyrosine kinase inhibitor resistance -0.409565217 -0.489130435 0 kegg kegg NA NA no no no no no no Propanoate metabolism EGFR tyrosine kinase inhibitor resistance 0 0.764822134 0.754182754 kegg kegg NA NA no no no no no no Pyruvate metabolism EGFR tyrosine kinase inhibitor resistance 0 0.788537549 0.659459459 kegg kegg NA NA no no no no no no Selenocompound metabolism EGFR tyrosine kinase inhibitor resistance 0.496521739 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism EGFR tyrosine kinase inhibitor resistance 0 -0.731225296 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism EGFR tyrosine kinase inhibitor resistance 0 -0.418972332 0 kegg kegg NA NA no no no no no no Thiamine metabolism EGFR tyrosine kinase inhibitor resistance 0 0.710474308 0 kegg kegg NA NA no no no no no no Tryptophan metabolism EGFR tyrosine kinase inhibitor resistance 0 0 0.478249678 kegg kegg NA NA no up no no no no Ubiquinone and other terpenoid-quinone biosynthesis EGFR tyrosine kinase inhibitor resistance 0 0 0.441698842 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" EGFR tyrosine kinase inhibitor resistance 0 0 0.482110682 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis EGFR tyrosine kinase inhibitor resistance 0.488695652 0.472332016 0 kegg kegg NA NA no no no no no no ABC transporters Endocrine and other factor-regulated calcium reabsorption -0.670434783 0 0 kegg kegg NA NA no up up no no no Adherens junction Endocrine and other factor-regulated calcium reabsorption 0 0.482213439 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Endocrine and other factor-regulated calcium reabsorption 0.74 0.860671937 0.676705277 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Endocrine and other factor-regulated calcium reabsorption 0 -0.659090909 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Endocrine and other factor-regulated calcium reabsorption -0.604347826 -0.664031621 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Endocrine and other factor-regulated calcium reabsorption 0.915652174 0.911067194 0.824453024 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Endocrine and other factor-regulated calcium reabsorption -0.626086957 -0.614624506 -0.56962677 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Endocrine and other factor-regulated calcium reabsorption -0.529565217 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Endocrine and other factor-regulated calcium reabsorption -0.432173913 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 0.540513834 0.477734878 kegg kegg NA NA no no no no no no Apelin signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 0.609683794 0 kegg kegg NA NA no no no no no no Apoptosis Endocrine and other factor-regulated calcium reabsorption -0.455652174 -0.593873518 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Endocrine and other factor-regulated calcium reabsorption -0.700869565 -0.654150198 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Endocrine and other factor-regulated calcium reabsorption -0.6 -0.601778656 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Endocrine and other factor-regulated calcium reabsorption 0 0 -0.536164736 kegg kegg NA NA no no no no no no Autophagy - animal Endocrine and other factor-regulated calcium reabsorption -0.412173913 -0.586956522 -0.494465894 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 -0.596837945 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Endocrine and other factor-regulated calcium reabsorption -0.473043478 -0.725296443 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Endocrine and other factor-regulated calcium reabsorption 0 0.480237154 0.424453024 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 -0.627470356 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Endocrine and other factor-regulated calcium reabsorption 0.73826087 0.854743083 0.603346203 kegg kegg NA NA no up up no no no cAMP signaling pathway Endocrine and other factor-regulated calcium reabsorption 0.426086957 0 0.492921493 yes kegg kegg NA NA no up up no no no Carbon metabolism Endocrine and other factor-regulated calcium reabsorption 0 -0.429841897 -0.474388674 kegg kegg NA NA no no no no no no Cardiac muscle contraction Endocrine and other factor-regulated calcium reabsorption 0.530434783 0.791501976 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Endocrine and other factor-regulated calcium reabsorption 0 -0.602766798 0 kegg kegg NA NA no no no no no no Cell cycle Endocrine and other factor-regulated calcium reabsorption 0 0.47826087 0 kegg kegg NA NA no no no no no no Cellular senescence Endocrine and other factor-regulated calcium reabsorption 0 -0.469367589 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 -0.674901186 0 kegg kegg NA NA no no no no no no Circadian entrainment Endocrine and other factor-regulated calcium reabsorption 0.693043478 0.691699605 0.852252252 kegg kegg NA NA no up up no no no Circadian rhythm Endocrine and other factor-regulated calcium reabsorption 0 0.416007905 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Endocrine and other factor-regulated calcium reabsorption 0 0 -0.419305019 kegg kegg NA NA no no no no no no Collinsella Endocrine and other factor-regulated calcium reabsorption 0 -0.44279482 0 Genus kegg 0.128 NA no no no no no no Complement and coagulation cascades Endocrine and other factor-regulated calcium reabsorption 0 -0.633399209 0 kegg kegg NA NA no no no no no no Coprococcus Endocrine and other factor-regulated calcium reabsorption 0 0 -0.427698051 butyrate-producing Genus kegg 0.612 NA no no no no no no Cortisol synthesis and secretion Endocrine and other factor-regulated calcium reabsorption 0.803478261 0.745059289 0.859202059 kegg kegg NA NA no no up no no no Cushing syndrome Endocrine and other factor-regulated calcium reabsorption 0.82173913 0.744071146 0.694208494 kegg kegg NA NA no no up no no no Dopaminergic synapse Endocrine and other factor-regulated calcium reabsorption 0.63826087 0.825098814 0.722265122 kegg kegg NA NA no up no no no no Drug metabolism - other enzymes Endocrine and other factor-regulated calcium reabsorption 0 0 -0.681081081 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Endocrine and other factor-regulated calcium reabsorption 0 0.538537549 0 kegg kegg NA NA no no no no no no Endocrine resistance Endocrine and other factor-regulated calcium reabsorption 0.76173913 0.599802372 0.774259974 kegg kegg NA NA no no no no no no Endocytosis Endocrine and other factor-regulated calcium reabsorption 0 -0.56916996 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 0 0.587129987 kegg kegg NA NA no no no no no no Ether lipid metabolism Endocrine and other factor-regulated calcium reabsorption 0.430434783 0 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Endocrine and other factor-regulated calcium reabsorption -0.562608696 -0.697628458 0 kegg kegg NA NA no no no no no no Fatty acid degradation Endocrine and other factor-regulated calcium reabsorption -0.673913043 -0.757905138 -0.565508366 kegg kegg NA NA no no no no no no Fatty acid metabolism Endocrine and other factor-regulated calcium reabsorption -0.670434783 -0.756916996 -0.448133848 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 -0.659090909 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Endocrine and other factor-regulated calcium reabsorption -0.533913043 -0.75 0 kegg kegg NA NA no no no no no no Ferroptosis Endocrine and other factor-regulated calcium reabsorption 0.444347826 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 -0.518774704 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Endocrine and other factor-regulated calcium reabsorption -0.551304348 0 -0.554954955 kegg kegg NA NA no no no no no no GABAergic synapse Endocrine and other factor-regulated calcium reabsorption -0.430434783 0 0 kegg kegg NA NA no up up no no no Galactose metabolism Endocrine and other factor-regulated calcium reabsorption -0.559130435 -0.670948617 -0.627541828 kegg kegg NA NA no no no no no no Gap junction Endocrine and other factor-regulated calcium reabsorption 0.809565217 0.531620553 0.716602317 kegg kegg NA NA no no no no no no Glucagon signaling pathway Endocrine and other factor-regulated calcium reabsorption 0.717391304 0.866600791 0.58970399 kegg kegg NA NA no no no no no no Glutamatergic synapse Endocrine and other factor-regulated calcium reabsorption 0.643478261 0 0.614414414 kegg kegg NA NA no up up no no no Glutathione metabolism Endocrine and other factor-regulated calcium reabsorption 0 0.707509881 0.43037323 kegg kegg NA NA no no no no no no Glycerolipid metabolism Endocrine and other factor-regulated calcium reabsorption -0.50173913 0 -0.401029601 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Endocrine and other factor-regulated calcium reabsorption 0 0.522727273 0.424967825 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Endocrine and other factor-regulated calcium reabsorption 0 -0.469367589 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Endocrine and other factor-regulated calcium reabsorption 0 0 -0.441698842 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Endocrine and other factor-regulated calcium reabsorption 0.647826087 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Endocrine and other factor-regulated calcium reabsorption 0 -0.598814229 -0.620592021 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Endocrine and other factor-regulated calcium reabsorption -0.691304348 -0.64229249 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Endocrine and other factor-regulated calcium reabsorption 0.817391304 0.755928854 0.775032175 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Endocrine and other factor-regulated calcium reabsorption 0 0 0.517889318 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Endocrine and other factor-regulated calcium reabsorption 0.446086957 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Endocrine and other factor-regulated calcium reabsorption 0.426956522 0.497035573 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Endocrine and other factor-regulated calcium reabsorption -0.453043478 -0.62944664 -0.502702703 kegg kegg NA NA no no no no no no Histidine metabolism Endocrine and other factor-regulated calcium reabsorption -0.45826087 0 -0.511969112 kegg kegg NA NA no no no no no no IL-17 signaling pathway Endocrine and other factor-regulated calcium reabsorption -0.454782609 -0.648221344 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Endocrine and other factor-regulated calcium reabsorption 0.86 0.884387352 0.837580438 kegg kegg NA NA no no no no no no Insulin secretion Endocrine and other factor-regulated calcium reabsorption 0.828695652 0.821146245 0.820592021 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 0.533596838 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Endocrine and other factor-regulated calcium reabsorption -0.416521739 -0.52173913 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Endocrine and other factor-regulated calcium reabsorption 0 0.435770751 0 kegg kegg NA NA no no no no no no Long-term depression Endocrine and other factor-regulated calcium reabsorption 0.899130435 0.562252964 0.818790219 kegg kegg NA NA no no no no no no Longevity regulating pathway Endocrine and other factor-regulated calcium reabsorption 0 0 0.408494208 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Endocrine and other factor-regulated calcium reabsorption 0 -0.517786561 0 kegg kegg NA NA no no no no no no Lysosome Endocrine and other factor-regulated calcium reabsorption 0 -0.587944664 -0.476447876 kegg kegg NA NA no no no no no no MAPK signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 -0.546442688 -0.532046332 kegg kegg NA NA no no no no no no Melanogenesis Endocrine and other factor-regulated calcium reabsorption 0.915652174 0.92687747 0.877477477 kegg kegg NA NA no no no no no no Mitophagy - animal Endocrine and other factor-regulated calcium reabsorption 0.567826087 0.747035573 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Endocrine and other factor-regulated calcium reabsorption 0 0.630434783 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 0.509881423 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Endocrine and other factor-regulated calcium reabsorption 0 -0.444664032 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Endocrine and other factor-regulated calcium reabsorption 0 0.542490119 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Endocrine and other factor-regulated calcium reabsorption 0 -0.501976285 0 kegg kegg NA NA no no no no no no Necroptosis Endocrine and other factor-regulated calcium reabsorption 0.559130435 0.416996047 0.412355212 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Endocrine and other factor-regulated calcium reabsorption 0 -0.690711462 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 -0.421936759 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Endocrine and other factor-regulated calcium reabsorption -0.416521739 -0.609683794 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Endocrine and other factor-regulated calcium reabsorption -0.637391304 -0.559288538 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Endocrine and other factor-regulated calcium reabsorption -0.628695652 -0.64229249 -0.455598456 kegg kegg NA NA no no no no no no Nitrogen metabolism Endocrine and other factor-regulated calcium reabsorption -0.444347826 -0.4743083 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Endocrine and other factor-regulated calcium reabsorption -0.720869565 -0.764822134 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Endocrine and other factor-regulated calcium reabsorption 0.530434783 0.7756917 0.486229086 kegg kegg NA NA no no no no no no Olfactory transduction Endocrine and other factor-regulated calcium reabsorption 0 -0.588932806 -0.431917632 kegg kegg NA NA no no no no no no Oscillospira Endocrine and other factor-regulated calcium reabsorption 0 -0.462450593 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Endocrine and other factor-regulated calcium reabsorption -0.671304348 -0.792490119 0 kegg kegg NA NA no no no no no no Other glycan degradation Endocrine and other factor-regulated calcium reabsorption -0.706086957 0 -0.43037323 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Endocrine and other factor-regulated calcium reabsorption 0.806086957 0.747035573 0.828314028 kegg kegg NA NA no up up no no no Oxidative phosphorylation Endocrine and other factor-regulated calcium reabsorption 0.497391304 0.781620553 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Endocrine and other factor-regulated calcium reabsorption -0.503478261 -0.743083004 -0.512998713 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Endocrine and other factor-regulated calcium reabsorption 0.552173913 0.776679842 0.667181467 kegg kegg NA NA no no no no no no Pentose phosphate pathway Endocrine and other factor-regulated calcium reabsorption 0 -0.664031621 0 kegg kegg NA NA no no no no no no Peroxisome Endocrine and other factor-regulated calcium reabsorption -0.713043478 -0.795454545 0 kegg kegg NA NA no no no no no no Phagosome Endocrine and other factor-regulated calcium reabsorption 0 -0.579051383 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Endocrine and other factor-regulated calcium reabsorption -0.420869565 0 0 yes kegg kegg NA NA no up up no no no Platelet activation Endocrine and other factor-regulated calcium reabsorption 0.430434783 0.4743083 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Endocrine and other factor-regulated calcium reabsorption 0 0.434782609 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Endocrine and other factor-regulated calcium reabsorption -0.48 -0.753952569 0 kegg kegg NA NA no no no no no no Prevotella Endocrine and other factor-regulated calcium reabsorption 0 0 0.445587261 acetate-producing Genus kegg 0.287 NA no no no no no no Prolactin signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 -0.57312253 0 kegg kegg NA NA no no no no no no Proteasome Endocrine and other factor-regulated calcium reabsorption 0 0 -0.531531532 kegg kegg NA NA no no no no no no Protein export Endocrine and other factor-regulated calcium reabsorption 0 0.509881423 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Endocrine and other factor-regulated calcium reabsorption 0 0.580039526 0 kegg kegg NA NA no no no no no no Purine metabolism Endocrine and other factor-regulated calcium reabsorption 0 0.545454545 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Endocrine and other factor-regulated calcium reabsorption -0.515652174 0 -0.474388674 kegg kegg NA NA no no no no no no Ras signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 0.497035573 0 yes kegg kegg NA NA no up up no no no Regulation of lipolysis in adipocytes Endocrine and other factor-regulated calcium reabsorption 0.816521739 0.791501976 0.873616474 kegg kegg NA NA no no no no no no Relaxin signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 0 0.435778636 kegg kegg NA NA no no no no no no Renin secretion Endocrine and other factor-regulated calcium reabsorption 0.789565217 0.855731225 0.911454311 kegg kegg NA NA no no no no no no Renin-angiotensin system Endocrine and other factor-regulated calcium reabsorption 0 -0.678853755 -0.470785071 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Endocrine and other factor-regulated calcium reabsorption 0 0.770750988 0 kegg kegg NA NA no no up no no no Ribosome Endocrine and other factor-regulated calcium reabsorption 0.432173913 0.691699605 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Endocrine and other factor-regulated calcium reabsorption -0.51826087 -0.567193676 0 kegg kegg NA NA no no no no no no RNA degradation Endocrine and other factor-regulated calcium reabsorption 0 0.616600791 0 kegg kegg NA NA no no no no no no RNA polymerase Endocrine and other factor-regulated calcium reabsorption 0 0.53458498 0 kegg kegg NA NA no no no no no no Serotonergic synapse Endocrine and other factor-regulated calcium reabsorption 0.408695652 0 0.488545689 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Endocrine and other factor-regulated calcium reabsorption -0.690434783 -0.568181818 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Endocrine and other factor-regulated calcium reabsorption 0 0 -0.545431145 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 -0.484189723 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Endocrine and other factor-regulated calcium reabsorption -0.665217391 -0.756916996 -0.646846847 kegg kegg NA NA no no no no no no Steroid biosynthesis Endocrine and other factor-regulated calcium reabsorption 0.415652174 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Endocrine and other factor-regulated calcium reabsorption 0 0 -0.511196911 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Endocrine and other factor-regulated calcium reabsorption 0 -0.633399209 -0.488030888 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 -0.499011858 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Endocrine and other factor-regulated calcium reabsorption 0.413043478 0.497035573 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Endocrine and other factor-regulated calcium reabsorption 0 -0.549407115 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Endocrine and other factor-regulated calcium reabsorption 0 -0.587944664 0 kegg kegg NA NA no no no no no no Thermogenesis Endocrine and other factor-regulated calcium reabsorption 0.59826087 0.791501976 0 kegg kegg NA NA no no no no no no Thiamine metabolism Endocrine and other factor-regulated calcium reabsorption -0.425217391 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 0.597826087 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Endocrine and other factor-regulated calcium reabsorption 0.74 0.869565217 0.758558559 kegg kegg NA NA no no no no no no TNF signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 -0.447628458 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Endocrine and other factor-regulated calcium reabsorption 0 -0.619565217 0 yes kegg kegg NA NA no no no no no no Type I diabetes mellitus Endocrine and other factor-regulated calcium reabsorption 0 -0.481225296 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Endocrine and other factor-regulated calcium reabsorption 0 0 -0.467438867 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Endocrine and other factor-regulated calcium reabsorption 0.617391304 0.782608696 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Endocrine and other factor-regulated calcium reabsorption 0.751304348 0.799407115 0.727927928 kegg kegg NA NA no no no no no no Wnt signaling pathway Endocrine and other factor-regulated calcium reabsorption 0.559130435 0.624505929 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Endocrine resistance 0 0 -0.504761905 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Endocrine resistance -0.629565217 0 -0.536422136 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Endocrine resistance -0.513043478 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Endocrine resistance -0.553913043 0 0 kegg kegg NA NA no up no no no no Ascorbate and aldarate metabolism Endocrine resistance 0 0 -0.487516088 kegg kegg NA NA no no no no no no beta-Alanine metabolism Endocrine resistance -0.457391304 0 -0.425225225 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Endocrine resistance -0.571304348 -0.549407115 0 kegg kegg NA NA no no no no no no Butanoate metabolism Endocrine resistance -0.415652174 0 -0.417503218 kegg kegg NA NA no no no no no no Carbon metabolism Endocrine resistance -0.540869565 -0.668972332 -0.505276705 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Endocrine resistance 0 0 -0.55006435 kegg kegg NA NA no no no no no no Clostridium Endocrine resistance 0 -0.622490144 0 Genus kegg 0.925 NA no no no no no no Dorea Endocrine resistance -0.493043478 0 0 Genus kegg 0.00362 NA up no dn no no no Drug metabolism - cytochrome P450 Endocrine resistance -0.442608696 0 -0.587387387 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Endocrine resistance -0.634782609 0 -0.636036036 kegg kegg NA NA no no no no no no Ether lipid metabolism Endocrine resistance 0.430434783 0 0 kegg kegg NA NA no no no no no no Fatty acid degradation Endocrine resistance -0.505217391 0 -0.54954955 kegg kegg NA NA no no no no no no Fatty acid elongation Endocrine resistance -0.44173913 -0.505928854 -0.426769627 kegg kegg NA NA no no no no no no Fatty acid metabolism Endocrine resistance -0.565217391 0 -0.461261261 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Endocrine resistance -0.502608696 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Endocrine resistance -0.489565217 0 -0.427541828 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Endocrine resistance 0 0.460474308 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Endocrine resistance 0 0.414031621 0.428056628 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Endocrine resistance -0.475652174 0 -0.411840412 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Endocrine resistance 0 0 -0.405920206 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Endocrine resistance 0.60173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Endocrine resistance 0 -0.533596838 -0.541827542 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Endocrine resistance 0 0.505928854 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Endocrine resistance -0.472173913 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Endocrine resistance -0.406086957 0 -0.414157014 kegg kegg NA NA no no no no no no Linoleic acid metabolism Endocrine resistance -0.451304348 0 0 kegg kegg NA NA no no no no no no Lysine degradation Endocrine resistance 0 0.454545455 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Endocrine resistance -0.50173913 0 -0.597940798 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Endocrine resistance -0.52 0 0 kegg kegg NA NA no no no no no no Odoribacter Endocrine resistance -0.479268035 -0.61961557 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Other glycan degradation Endocrine resistance -0.5 0 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Endocrine resistance 0 0.613636364 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Endocrine resistance 0 0 -0.433719434 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Endocrine resistance 0 0 -0.423938224 kegg kegg NA NA no no no no no no Pentose phosphate pathway Endocrine resistance -0.476521739 -0.488142292 0 kegg kegg NA NA no no no no no no Prevotella Endocrine resistance 0 0.518571986 0.61282385 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Endocrine resistance 0 -0.423913043 0 kegg kegg NA NA no no no no no no Purine metabolism Endocrine resistance 0 0.455533597 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Endocrine resistance -0.513913043 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Endocrine resistance 0 0 -0.477220077 kegg kegg NA NA no no no no no no Ruminococcus Endocrine resistance 0.437391304 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Sphingolipid metabolism Endocrine resistance 0 0 -0.435778636 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Endocrine resistance -0.646086957 0 -0.492406692 kegg kegg NA NA no no no no no no Steroid biosynthesis Endocrine resistance 0.44173913 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Endocrine resistance -0.406086957 0 -0.417245817 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Endocrine resistance 0 0.517786561 0 kegg kegg NA NA no no no no no no Thiamine metabolism Endocrine resistance -0.445217391 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Endocrine resistance -0.431304348 0 -0.486743887 kegg kegg NA NA no up no no no no "Valine, leucine and isoleucine degradation" Endocrine resistance 0 0 -0.405148005 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Endocytosis 0 0 -0.482882883 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Endocytosis -0.419130435 0 0 kegg kegg NA NA no no no no no no Autophagy - other Endocytosis -0.439130435 0 0 kegg kegg NA NA no no no no no no Bacteroides Endocytosis 0.450434783 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Endocytosis -0.672173913 -0.600790514 -0.494465894 kegg kegg NA NA no no no no no no Base excision repair Endocytosis -0.420869565 -0.46541502 -0.508365508 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Endocytosis 0.676521739 0.727272727 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Endocytosis 0 -0.781620553 0 kegg kegg NA NA no no no no no no Carbon metabolism Endocytosis 0.48173913 0.524703557 0 kegg kegg NA NA no no no no no no Cell cycle Endocytosis -0.606956522 -0.649209486 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Endocytosis 0 0.641304348 0.409009009 kegg kegg NA NA no no no no no no Chemokine signaling pathway Endocytosis 0 0.531620553 0.572458172 kegg kegg NA NA no no no no no no DNA replication Endocytosis -0.420869565 -0.462450593 0 kegg kegg NA NA no no no no no no Endocrine resistance Endocytosis 0 -0.616600791 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Endocytosis -0.608695652 -0.732213439 -0.442213642 kegg kegg NA NA no no no no no no Fanconi anemia pathway Endocytosis -0.495652174 -0.557312253 -0.457657658 kegg kegg NA NA no no no no no no FoxO signaling pathway Endocytosis 0 0 -0.458687259 kegg kegg NA NA no no no no no no Glutathione metabolism Endocytosis 0 -0.564229249 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Endocytosis -0.546086957 -0.444664032 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Endocytosis 0 -0.71541502 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Endocytosis 0.512173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Endocytosis 0.411304348 0.601778656 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Endocytosis 0 -0.767786561 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Endocytosis 0 0.415019763 0 kegg kegg NA NA no no no no no no Homologous recombination Endocytosis 0 -0.497035573 -0.598970399 kegg kegg NA NA no no no no no no Lysosome Endocytosis 0.495652174 0.748023715 0 kegg kegg NA NA no no no no no no Mismatch repair Endocytosis 0 -0.509881423 0 kegg kegg NA NA no no no no no no Mitophagy - animal Endocytosis 0 -0.584980237 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Endocytosis -0.660869565 -0.524703557 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Endocytosis -0.444347826 -0.437747036 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Endocytosis 0 0.726284585 0 kegg kegg NA NA up up up no no no Nicotinate and nicotinamide metabolism Endocytosis 0.428695652 0.486166008 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Endocytosis 0.557391304 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Endocytosis -0.445217391 -0.587944664 -0.595366795 kegg kegg NA NA no no no no no no One carbon pool by folate Endocytosis -0.499130435 -0.562252964 0 kegg kegg NA NA no no no no no no Oocyte meiosis Endocytosis -0.486956522 0 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Endocytosis -0.616521739 -0.577075099 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Endocytosis -0.444347826 -0.446640316 0 kegg kegg NA NA no no no no no no p53 signaling pathway Endocytosis -0.545217391 -0.442687747 -0.586100386 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Endocytosis 0 0.462450593 0 kegg kegg NA NA no no dn no no no Pentose phosphate pathway Endocytosis 0.637391304 0.750988142 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Endocytosis -0.453913043 0 0 kegg kegg NA NA no no no no no no Platinum drug resistance Endocytosis 0 0 -0.634234234 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Endocytosis 0 -0.706521739 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Endocytosis 0.41826087 0.551383399 0.537451737 kegg kegg NA NA no no no no no no Protein export Endocytosis -0.633913043 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Endocytosis 0 -0.545454545 0 kegg kegg NA NA no no no no no no Purine metabolism Endocytosis 0 -0.699604743 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Endocytosis 0 -0.42687747 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Endocytosis 0 -0.442687747 -0.462805663 kegg kegg NA NA no no no no no no Ribosome Endocytosis -0.495652174 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Endocytosis -0.594782609 -0.589920949 0 kegg kegg NA NA no no no no no no RNA degradation Endocytosis -0.615652174 -0.470355731 0 kegg kegg NA NA no no no no no no RNA polymerase Endocytosis -0.595652174 -0.654150198 0 kegg kegg NA NA no no no no no no Ruminococcus Endocytosis -0.413043478 0 0.440926641 acetate-producing Genus kegg 0.335 NA no no no no no no Selenocompound metabolism Endocytosis -0.575652174 -0.493083004 -0.466409266 kegg kegg NA NA no no no no no no Sphingolipid metabolism Endocytosis 0.423478261 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Endocytosis 0 0.741106719 0 kegg kegg NA NA no no no no no no Spliceosome Endocytosis -0.44 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Endocytosis -0.680869565 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Endocytosis 0 -0.423913043 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Endocytosis 0 -0.566205534 -0.428314028 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Endocytosis -0.532173913 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Endocytosis -0.68 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Endocytosis 0 -0.531620553 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Endocytosis 0 -0.45256917 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Endocytosis 0 -0.414031621 -0.437580438 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Endocytosis 0 -0.663043478 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Endocytosis 0.42173913 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Endometrial cancer -0.530434783 -0.52173913 0 kegg kegg NA NA no no no no no no Adherens junction Endometrial cancer 0 -0.554347826 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Endometrial cancer 0 0.635375494 0 kegg kegg NA NA no no no no no no African trypanosomiasis Endometrial cancer 0.445217391 0 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Endometrial cancer 0.537391304 0.65513834 0.61981982 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Endometrial cancer 0 0.484189723 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Endometrial cancer 0.786956522 0.774703557 0.654568855 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Endometrial cancer -0.669565217 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Endometrial cancer 0 -0.482213439 0 kegg kegg NA NA no no no no no no Amoebiasis Endometrial cancer 0 0.571146245 0 kegg kegg NA NA no no no no no no Amphetamine addiction Endometrial cancer 0 -0.427865613 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Endometrial cancer 0 -0.447628458 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Endometrial cancer 0 0 -0.411068211 kegg kegg NA NA no no no no no no Apelin signaling pathway Endometrial cancer 0 -0.51284585 0 kegg kegg NA NA no no no no no no Apoptosis Endometrial cancer 0 0.60770751 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Endometrial cancer -0.666956522 0 -0.689060489 kegg kegg NA NA no no no no no no Arginine and proline metabolism Endometrial cancer 0 0.516798419 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Endometrial cancer 0 0.453557312 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Endometrial cancer -0.427826087 -0.543478261 0 kegg kegg NA NA no no no no no no Autophagy - animal Endometrial cancer 0.58 0.79743083 0.612870013 kegg kegg NA NA no no no no no no Autophagy - other Endometrial cancer 0 0.507905138 0.735907336 kegg kegg NA NA no no no no no no Axon guidance Endometrial cancer 0.591304348 0 0.503732304 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Endometrial cancer 0.547826087 0.70256917 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Endometrial cancer 0 -0.545454545 -0.446332046 kegg kegg NA NA no no no no no no beta-Alanine metabolism Endometrial cancer -0.586956522 -0.731225296 -0.451480051 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Endometrial cancer -0.605217391 -0.443675889 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Endometrial cancer -0.654782609 -0.719367589 0 kegg kegg NA NA no no no no no no Butanoate metabolism Endometrial cancer -0.58 -0.777667984 -0.414414414 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Endometrial cancer 0.733043478 0.768774704 0.551351351 kegg kegg NA NA no no no no no no Calcium signaling pathway Endometrial cancer 0.453913043 0 0.407979408 kegg kegg NA NA no up up no no no cAMP signaling pathway Endometrial cancer 0.514782609 0.619565217 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Endometrial cancer 0.737391304 0.843873518 0.631660232 kegg kegg NA NA no no no no no no Carbon metabolism Endometrial cancer -0.540869565 -0.428853755 -0.406692407 kegg kegg NA NA no no no no no no Cell cycle Endometrial cancer 0 0 0.431402831 kegg kegg NA NA no no no no no no Cellular senescence Endometrial cancer 0 0.506916996 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Endometrial cancer 0.453043478 0 0 kegg kegg NA NA no no no no no no Chagas disease Endometrial cancer 0.539130435 0.759881423 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Endometrial cancer -0.614782609 0 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Endometrial cancer 0.492173913 0.469367589 0 kegg kegg NA NA no no no no no no Cholinergic synapse Endometrial cancer 0.499130435 0 0.556756757 kegg kegg NA NA no no no no no no Circadian entrainment Endometrial cancer 0 -0.614624506 -0.428056628 kegg kegg NA NA no up up no no no Circadian rhythm Endometrial cancer 0.493913043 0 0.651737452 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Endometrial cancer -0.612173913 -0.834980237 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Endometrial cancer 0 -0.509881423 -0.601287001 kegg kegg NA NA no no no no no no Colorectal cancer Endometrial cancer 0.704347826 0.416996047 0.8 kegg kegg NA NA no no no no no no Complement and coagulation cascades Endometrial cancer 0 0 -0.432947233 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Endometrial cancer -0.466086957 -0.725296443 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Endometrial cancer 0 0 -0.460746461 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Endometrial cancer 0 0.625494071 0 kegg kegg NA NA no no no no no no DNA replication Endometrial cancer 0 -0.674901186 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Endometrial cancer 0 -0.419960474 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Endometrial cancer -0.582608696 -0.791501976 -0.429343629 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Endometrial cancer -0.633913043 -0.716403162 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Endometrial cancer 0 0.536561265 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Endometrial cancer 0.866086957 0.848814229 0.873101673 kegg kegg NA NA no no no no no no Estrogen signaling pathway Endometrial cancer -0.474782609 -0.704545455 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Endometrial cancer 0 0.471343874 0 kegg kegg NA NA no no no no no no Fatty acid elongation Endometrial cancer -0.614782609 -0.683794466 -0.458172458 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Endometrial cancer 0.756521739 0.690711462 0 kegg kegg NA NA no no no no no no Ferroptosis Endometrial cancer 0 0 -0.501930502 kegg kegg NA NA no no no no no no Focal adhesion Endometrial cancer 0 -0.662055336 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Endometrial cancer 0 0.494071146 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Endometrial cancer -0.471304348 0.463438735 0 kegg kegg NA NA no no no no no no Gastric acid secretion Endometrial cancer 0 -0.614624506 -0.404633205 kegg kegg NA NA no no no no no no Glutathione metabolism Endometrial cancer -0.486086957 0 -0.683397683 kegg kegg NA NA no no no no no no Glycerolipid metabolism Endometrial cancer 0 0 0.499356499 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Endometrial cancer 0 0 0.47001287 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Endometrial cancer -0.463478261 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Endometrial cancer -0.653043478 -0.716403162 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Endometrial cancer 0.447826087 0.787549407 0.428056628 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Endometrial cancer 0.47826087 0 0.428314028 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Endometrial cancer 0 -0.423913043 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Endometrial cancer 0.574782609 0 0.457400257 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Endometrial cancer 0 0.470355731 0 kegg kegg NA NA no no no no no no GnRH secretion Endometrial cancer 0.869565217 0.860671937 0.74002574 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Endometrial cancer 0.576521739 0.644268775 0.421621622 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Endometrial cancer 0.483478261 0 0.665637066 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Endometrial cancer 0 -0.57312253 0 kegg kegg NA NA no no no no no no Hepatitis B Endometrial cancer 0.674782609 0.749011858 0.77039897 kegg kegg NA NA no no no no no no Hepatitis C Endometrial cancer 0.544347826 0.657114625 0.701415701 kegg kegg NA NA no no no no no no Hippo signaling pathway Endometrial cancer 0 -0.539525692 0 kegg kegg NA NA no no no no no no Histidine metabolism Endometrial cancer -0.440869565 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Endometrial cancer 0 0.538537549 0 kegg kegg NA NA no no no no no no Huntington disease Endometrial cancer 0 -0.418972332 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Endometrial cancer 0 0 0.425997426 kegg kegg NA NA no no no no no no Insulin resistance Endometrial cancer 0.628695652 0.83201581 0.726640927 kegg kegg NA NA no no no no no no Insulin signaling pathway Endometrial cancer 0 -0.438735178 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Endometrial cancer 0 0.652173913 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Endometrial cancer 0 -0.416996047 0 kegg kegg NA NA no no no no no no Long-term potentiation Endometrial cancer 0 -0.551383399 0.507078507 kegg kegg NA NA no no up no no no Longevity regulating pathway Endometrial cancer 0.444347826 0 0 kegg kegg NA NA no no no no no no Lysine degradation Endometrial cancer 0 0 0.554954955 kegg kegg NA NA no no no no no no Malaria Endometrial cancer 0 0 -0.416473616 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Endometrial cancer 0.633913043 0 0.525611326 kegg kegg NA NA no no no no no no MAPK signaling pathway Endometrial cancer 0 0 0.671299871 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Endometrial cancer -0.607826087 -0.838932806 -0.471814672 kegg kegg NA NA no no no no no no MicroRNAs in cancer Endometrial cancer 0.466086957 0.866600791 0.896267696 kegg kegg NA NA no no no no no no Mineral absorption Endometrial cancer 0 0 -0.497039897 kegg kegg NA NA no no no no no no Mismatch repair Endometrial cancer -0.605217391 -0.7243083 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Endometrial cancer 0.406086957 0 0.574259974 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Endometrial cancer -0.420869565 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Endometrial cancer 0 -0.48715415 0 kegg kegg NA NA no no no no no no Necroptosis Endometrial cancer 0 0 -0.475675676 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Endometrial cancer 0.753913043 0.812252964 0.61029601 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Endometrial cancer 0 0 -0.403603604 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Endometrial cancer 0.493913043 0.755928854 0.599485199 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Endometrial cancer 0 0.52173913 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Endometrial cancer 0 0.497035573 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Endometrial cancer 0 0.648221344 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Endometrial cancer -0.604347826 -0.731225296 0 kegg kegg NA NA no no no no no no Notch signaling pathway Endometrial cancer 0.606956522 0.581027668 0.487516088 kegg kegg NA NA no no no no no no Nucleotide excision repair Endometrial cancer -0.422608696 -0.662055336 0 kegg kegg NA NA no no no no no no One carbon pool by folate Endometrial cancer 0 -0.580039526 0 kegg kegg NA NA no no no no no no Oocyte meiosis Endometrial cancer 0 -0.68083004 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Endometrial cancer 0 0.529644269 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Endometrial cancer 0 0 0.51994852 kegg kegg NA NA no no no no no no Oxidative phosphorylation Endometrial cancer 0 -0.41798419 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Endometrial cancer 0 -0.444664032 -0.561132561 kegg kegg NA NA no no no no no no Pancreatic cancer Endometrial cancer 0.729565217 0.432806324 0.438095238 kegg kegg NA NA no no no no no no Parkinson disease Endometrial cancer 0 0 -0.403088803 kegg kegg NA NA no no no no no no Pathways in cancer Endometrial cancer 0.574782609 0.684782609 0.628571429 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Endometrial cancer 0 0 -0.401544402 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Endometrial cancer -0.709565217 -0.707509881 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Endometrial cancer -0.557391304 -0.816205534 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Endometrial cancer 0.467826087 0 0.6002574 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Endometrial cancer 0.546086957 0.696640316 0.407979408 kegg kegg NA NA no up up no no no Phototransduction Endometrial cancer 0 -0.792490119 0 kegg kegg NA NA no no no no no no Platelet activation Endometrial cancer 0 -0.545454545 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Endometrial cancer -0.44173913 0 -0.406177606 kegg kegg NA NA no no no no no no PPAR signaling pathway Endometrial cancer 0 0.556324111 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Endometrial cancer -0.675652174 -0.793478261 -0.428056628 kegg kegg NA NA no no no no no no Prion disease Endometrial cancer 0 -0.490118577 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Endometrial cancer 0 0 0.65971686 kegg kegg NA NA no no no no no no Prolactin signaling pathway Endometrial cancer 0.685217391 0.729249012 0.547232947 kegg kegg NA NA no no no no no no Propanoate metabolism Endometrial cancer -0.514782609 -0.720355731 0 kegg kegg NA NA no no no no no no Proteasome Endometrial cancer 0 -0.694664032 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Endometrial cancer 0 0 0.451480051 yes kegg kegg NA NA no up up no no no Protein export Endometrial cancer 0 -0.495059289 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Endometrial cancer 0 -0.446640316 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Endometrial cancer -0.473913043 -0.638339921 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Endometrial cancer -0.556521739 -0.580039526 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Endometrial cancer -0.547826087 -0.717391304 0 kegg kegg NA NA no no no no no no Ras signaling pathway Endometrial cancer 0 -0.449604743 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Endometrial cancer -0.45826087 -0.729249012 -0.545173745 kegg kegg NA NA no no no no no no Relaxin signaling pathway Endometrial cancer 0.497391304 0.684782609 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Endometrial cancer 0.619130435 0 0 kegg kegg NA NA no no no no no no Renin secretion Endometrial cancer 0 -0.58201581 0 kegg kegg NA NA no no no no no no Retinol metabolism Endometrial cancer -0.608695652 -0.705533597 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Endometrial cancer 0 -0.523715415 0 kegg kegg NA NA no no up no no no RIG-I-like receptor signaling pathway Endometrial cancer 0.546086957 0.774703557 0.556241956 kegg kegg NA NA no no no no no no RNA degradation Endometrial cancer 0.419130435 0 0.532818533 kegg kegg NA NA no no no no no no RNA polymerase Endometrial cancer 0 -0.424901186 0 kegg kegg NA NA no no no no no no Shigellosis Endometrial cancer 0 0 -0.497554698 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Endometrial cancer 0.788695652 0.638339921 0.840926641 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Endometrial cancer 0 0.434782609 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Endometrial cancer 0.72 0.622529644 0.496010296 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Endometrial cancer 0.476521739 0 0.467696268 kegg kegg NA NA no no no no no no Spliceosome Endometrial cancer 0 0 0.526640927 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Endometrial cancer 0 0 -0.440669241 kegg kegg NA NA up no no no no no Steroid biosynthesis Endometrial cancer 0 -0.766798419 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Endometrial cancer -0.765217391 -0.730237154 0 kegg kegg NA NA no no no no no no Sulfur metabolism Endometrial cancer -0.473913043 -0.45256917 -0.48030888 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Endometrial cancer -0.540869565 -0.666007905 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Endometrial cancer 0.407826087 0.515810277 0.610810811 kegg kegg NA NA no no no no no no Taste transduction Endometrial cancer 0 -0.597826087 0.448391248 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Endometrial cancer 0 0.598814229 0.536679537 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Endometrial cancer 0 -0.488142292 0 kegg kegg NA NA no no no no no no Thermogenesis Endometrial cancer 0 -0.461462451 0 kegg kegg NA NA no no no no no no Thiamine metabolism Endometrial cancer 0 -0.566205534 0 kegg kegg NA NA no no no no no no Tight junction Endometrial cancer -0.433913043 -0.621541502 -0.743629344 kegg kegg NA NA no no no no no no TNF signaling pathway Endometrial cancer 0.686956522 0.84486166 0.45019305 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Endometrial cancer 0.596521739 0.717391304 0 yes kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Endometrial cancer 0.466956522 0.738142292 0.717117117 kegg kegg NA NA no no no no no no Tryptophan metabolism Endometrial cancer -0.614782609 -0.807312253 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Endometrial cancer 0.793913043 0.849802372 0.56036036 kegg kegg NA NA no no no no no no Tyrosine metabolism Endometrial cancer -0.742608696 -0.794466403 -0.521492921 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Endometrial cancer -0.647826087 -0.753952569 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Endometrial cancer -0.616521739 -0.79743083 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Endometrial cancer 0 0 0.405405405 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Endometrial cancer 0 -0.549407115 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Endometrial cancer 0.826086957 0.807312253 0.706306306 kegg kegg NA NA no no no no no no Vibrio cholerae infection Endometrial cancer 0 -0.542490119 -0.462805663 kegg kegg NA NA no no no no no no Viral carcinogenesis Endometrial cancer 0 0.579051383 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Endometrial cancer 0 0 -0.571428571 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Endometrial cancer 0.41826087 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Endometrial cancer 0.427826087 0 0.566280566 kegg kegg NA NA no no no no no no 16:0/18:2-PI+blood Eotaxin 0 -0.585714286 0 serum_phospholipids serum_cytokines 0.269 0.393 no no no no no no 16:0/20:4-PI+blood Eotaxin 0 -0.657142857 0 serum_phospholipids serum_cytokines 0.558 0.393 no no no no no no 18:0/18:2-PI+blood Eotaxin 0 -0.557142857 0 serum_phospholipids serum_cytokines 0.179 0.393 no no no no no no 20:2+blood Eotaxin 0 0 -0.654135338 serum_fattyacid serum_cytokines 0.478 0.393 no no no no no no 20:5/18:0-PC+blood Eotaxin 0 0 -0.487218045 serum_phospholipids serum_cytokines 3.97E-06 0.393 no up up no no no 22:6n3+blood Eotaxin 0 0 -0.478195489 serum_fattyacid serum_cytokines 0.792 0.393 no no no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Eotaxin -0.733333333 -0.523529412 0 urine_cometabolism serum_cytokines 0.0125 0.393 up up no no no no ACA+blood Eotaxin 0 0 -0.448275925 serum_bileacids serum_cytokines 0.338 0.393 no no no no no no Adrenergic signaling in cardiomyocytes Eotaxin 0 0 0.539135194 kegg serum_cytokines NA 0.393 no no up no no no Aldosterone synthesis and secretion Eotaxin 0 0 0.4969896 kegg serum_cytokines NA 0.393 no up up no no no Allograft rejection Eotaxin 0 0 -0.478927203 kegg serum_cytokines NA 0.393 no no no no no no Amphetamine addiction Eotaxin 0 0 0.46743295 kegg serum_cytokines NA 0.393 no no no no no no Anaerostipes Eotaxin 0 0.516224302 0 butyrate-producing Genus serum_cytokines 0.568 0.393 no no no no no no Antigen processing and presentation Eotaxin 0 0 -0.40941434 kegg serum_cytokines NA 0.393 no no no no no no Autoimmune thyroid disease Eotaxin 0 0 -0.478927203 kegg serum_cytokines NA 0.393 no no no no no no Biosynthesis of amino acids Eotaxin 0 0 -0.570881226 kegg serum_cytokines NA 0.393 no no no no no no Butyricimonas Eotaxin -0.555503621 0 0 butyrate-producing Genus serum_cytokines 0.17 0.393 no no no no no no CA+blood Eotaxin 0 0 0.533348639 serum_bileacids serum_cytokines 0.606 0.393 no no no no no no Carbon metabolism Eotaxin 0 0 -0.435686918 kegg serum_cytokines NA 0.393 no no no no no no Cell adhesion molecules Eotaxin 0 0 -0.493705528 kegg serum_cytokines NA 0.393 no no no no no no Cell cycle Eotaxin 0 0 0.477832512 kegg serum_cytokines NA 0.393 no no no no no no Chemical carcinogenesis - receptor activation Eotaxin 0 0 0.461959496 kegg serum_cytokines NA 0.393 no no no no no no Choline metabolism in cancer Eotaxin 0 0 0.476190476 kegg serum_cytokines NA 0.393 no no no no no no Choline+blood Eotaxin 0 0 -0.461654135 serum_choline serum_cytokines 0.0395 0.393 no up no no no no Cholinergic synapse Eotaxin -0.642857143 0 0.472906404 kegg serum_cytokines NA 0.393 no no no no no no Clostridium Eotaxin 0 -0.439532231 0 Genus serum_cytokines 0.925 0.393 no no no no no no Colorectal cancer Eotaxin 0 0 0.410509031 kegg serum_cytokines NA 0.393 no no no no no no Coprococcus Eotaxin 0 0 -0.414645044 butyrate-producing Genus serum_cytokines 0.612 0.393 no no no no no no Creatinine+blood Eotaxin 0 0 -0.503759398 serum_choline serum_cytokines 0.437 0.393 no no no no no no Cushing syndrome Eotaxin 0 0 0.424740011 kegg serum_cytokines NA 0.393 no no up no no no Cysteine+blood Eotaxin 0 0 -0.446616541 yes serum_aminoacids serum_cytokines 1.81E-07 0.393 dn up up no no no Cystine+blood Eotaxin 0.733333333 0 0 yes serum_aminoacids serum_cytokines 0.00028 0.393 up up no no no no Dopaminergic synapse Eotaxin 0 0 0.537493158 kegg serum_cytokines NA 0.393 no up no no no no Dorea Eotaxin 0 -0.490418993 0 Genus serum_cytokines 0.00362 0.393 up no dn no no no Endocytosis Eotaxin 0 0 -0.50410509 kegg serum_cytokines NA 0.393 no no no no no no ErbB signaling pathway Eotaxin 0 0 0.40120416 kegg serum_cytokines NA 0.393 no no no no no no Fc gamma R-mediated phagocytosis Eotaxin 0 0 -0.403393541 kegg serum_cytokines NA 0.393 no no no no no no Fluid shear stress and atherosclerosis Eotaxin 0 -0.529323308 0 kegg serum_cytokines NA 0.393 no no no no no no Gastric cancer Eotaxin 0 0 0.407224959 kegg serum_cytokines NA 0.393 no no no no no no Glioma Eotaxin 0 0 0.40831965 kegg serum_cytokines NA 0.393 no no no no no no Glucagon signaling pathway Eotaxin 0 0 0.503557745 kegg serum_cytokines NA 0.393 no no no no no no Graft-versus-host disease Eotaxin 0 0 -0.467980296 kegg serum_cytokines NA 0.393 no no no no no no HDCA+stool Eotaxin 0 0.769230769 0 stool_bileacids serum_cytokines 0.176 0.393 no no no no no no Hematopoietic cell lineage Eotaxin 0.653846154 0 0 kegg serum_cytokines NA 0.393 no no no no no no IL-17 signaling pathway Eotaxin 0 -0.454135338 -0.434044882 kegg serum_cytokines NA 0.393 no no no no no no Inflammatory mediator regulation of TRP channels Eotaxin 0 0 0.529830323 kegg serum_cytokines NA 0.393 no no no no no no L-2-Aminobutyric acid+blood Eotaxin 0 0.621428571 0 yes serum_aminoacids serum_cytokines 0.000328 0.393 up up no no no no L-Alanine+blood Eotaxin 0.672727273 0 0 yes serum_aminoacids serum_cytokines 0.00138 0.393 up up no no no no L-Asparagine+blood Eotaxin 0.696969697 0 0 serum_aminoacids serum_cytokines 0.784 0.393 no no no no no no L-Citrulline+blood Eotaxin 0 0.55 0 serum_aminoacids serum_cytokines 0.534 0.393 no no no no no no L-Glutamic acid+blood Eotaxin 0.806060606 0 0 yes serum_aminoacids serum_cytokines 6.20E-05 0.393 up up no no no no L-Glutamine+blood Eotaxin 0.76969697 0 0 serum_aminoacids serum_cytokines 0.639 0.393 no no no no no no L-Lysine+blood Eotaxin 0.648484848 0 0 yes serum_aminoacids serum_cytokines 0.0107 0.393 no up no no no no L-Ornithine+blood Eotaxin 0.733333333 0 0 serum_aminoacids serum_cytokines 0.175 0.393 no no no no no no Leukocyte transendothelial migration Eotaxin 0 -0.586466165 0 kegg serum_cytokines NA 0.393 no no no no no no Lipid and atherosclerosis Eotaxin 0 0 -0.417624521 kegg serum_cytokines NA 0.393 no no no no no no Long-term potentiation Eotaxin 0 0 0.438970991 kegg serum_cytokines NA 0.393 no no up no no no Lysosome Eotaxin 0 -0.463157895 0 kegg serum_cytokines NA 0.393 no no no no no no Measles Eotaxin 0 0.518796992 -0.5030104 kegg serum_cytokines NA 0.393 no no no no no no Melanogenesis Eotaxin 0 0 0.409961686 kegg serum_cytokines NA 0.393 no no no no no no mRNA surveillance pathway Eotaxin 0 0 0.463054187 kegg serum_cytokines NA 0.393 no no no no no no MUFA%+blood Eotaxin 0 0 -0.568421053 serum_fattyacid serum_cytokines 0.00142 0.393 up no dn no no no n3+blood Eotaxin 0 0 -0.479699248 serum_fattyacid serum_cytokines 0.806 0.393 no no no no no no Neuroactive ligand-receptor interaction Eotaxin 0 -0.469172932 0 kegg serum_cytokines NA 0.393 up up up no no no Neutrophil extracellular trap formation Eotaxin 0 -0.545864662 -0.483305966 kegg serum_cytokines NA 0.393 no no no no no no Non-small cell lung cancer Eotaxin 0 0 0.428571429 kegg serum_cytokines NA 0.393 no no no no no no Oxytocin signaling pathway Eotaxin 0 -0.538345865 0 kegg serum_cytokines NA 0.393 no no no no no no P-hydroxyhippuric acid+urine Eotaxin 0 0.526470588 0 urine_cometabolism serum_cytokines 0.436 0.393 no no no no no no p53 signaling pathway Eotaxin 0 0.580451128 0 kegg serum_cytokines NA 0.393 no no no no no no Pathogenic Escherichia coli infection Eotaxin 0 0 -0.40831965 kegg serum_cytokines NA 0.393 no no no no no no Peroxisome Eotaxin 0 0 -0.470169677 kegg serum_cytokines NA 0.393 no no no no no no Phagosome Eotaxin 0 0 -0.666119321 kegg serum_cytokines NA 0.393 no no no no no no Phosphatidylinositol signaling system Eotaxin 0 0 0.47454844 kegg serum_cytokines NA 0.393 no no no no no no Platelet activation Eotaxin 0 -0.509774436 0 kegg serum_cytokines NA 0.393 no no no no no no Platinum drug resistance Eotaxin 0 0 0.438423645 kegg serum_cytokines NA 0.393 no no no no no no Primary immunodeficiency Eotaxin 0 0.497744361 0 kegg serum_cytokines NA 0.393 no no no no no no Progesterone-mediated oocyte maturation Eotaxin 0 0.448120301 0 kegg serum_cytokines NA 0.393 no no no no no no Rap1 signaling pathway Eotaxin 0 -0.535338346 0 kegg serum_cytokines NA 0.393 no no no no no no Ras signaling pathway Eotaxin 0 0 0.532019704 yes kegg serum_cytokines NA 0.393 no up up no no no Signaling pathways regulating pluripotency of stem cells Eotaxin 0 0 0.434592228 kegg serum_cytokines NA 0.393 no no no no no no Spliceosome Eotaxin 0 0.685714286 0.435139573 kegg serum_cytokines NA 0.393 no no no no no no Staphylococcus aureus infection Eotaxin 0 0 -0.483305966 kegg serum_cytokines NA 0.393 up no no no no no Systemic lupus erythematosus Eotaxin 0 -0.448120301 -0.45210728 kegg serum_cytokines NA 0.393 no no no no no no T cell receptor signaling pathway Eotaxin -0.642857143 0 0 kegg serum_cytokines NA 0.393 no no no no no no TUDCA+blood Eotaxin 0 0 0.491042015 yes serum_bileacids serum_cytokines 0.0282 0.393 no no dn no no no Type I diabetes mellitus Eotaxin 0 0 -0.470169677 kegg serum_cytokines NA 0.393 no no no no no no UDCA+blood Eotaxin 0 0.532618622 0 yes serum_bileacids serum_cytokines 0.0939 0.393 no no dn no no no UFA%+blood Eotaxin 0 0 -0.517293233 serum_fattyacid serum_cytokines 0.0236 0.393 no dn no no no no Viral myocarditis Eotaxin 0 0 -0.484400657 kegg serum_cytokines NA 0.393 no no no no no no Viral protein interaction with cytokine and cytokine receptor Eotaxin 0 -0.52481203 0 kegg serum_cytokines NA 0.393 no no no no no no "12,13-EPOME+blood" EPA+blood 0 0 0.519015745 serum_ARA serum_ARA 0.901 0.212 no no no no no no 14:0/18:0-PC+blood EPA+blood 0 -0.830882353 0 serum_phospholipids serum_ARA 0.00289 0.212 up up no no no no 14:0/18:2-PC+blood EPA+blood 0.457142857 0 0 serum_phospholipids serum_ARA 0.102 0.212 no up no no no no 14:0/20:4-PC+blood EPA+blood 0.457142857 0 0 serum_phospholipids serum_ARA 0.486 0.212 no no no no no no 14:0+blood EPA+blood 0.478195489 0 0 yes serum_fattyacid serum_ARA 0.00572 0.212 up no dn no no no 16:0/16:0-PC+blood EPA+blood 0.455639098 0 0 serum_phospholipids serum_ARA 0.00079 0.212 no up up no no no 16:0/16:0-PI+blood EPA+blood 0 -0.774509804 0 serum_phospholipids serum_ARA 0.358 0.212 no no no no no no 16:0/16:1-PC+blood EPA+blood 0 -0.81372549 0 serum_phospholipids serum_ARA 0.00283 0.212 up up no no no no 16:0/16:1-PI+blood EPA+blood 0 -0.68872549 0 serum_phospholipids serum_ARA 0.262 0.212 no no no no no no 16:0/18:0-PC+blood EPA+blood 0.44962406 0 0 serum_phospholipids serum_ARA 0.521 0.212 no no no no no no 16:0/18:1-PE+blood EPA+blood 0 -0.759803922 0 serum_phospholipids serum_ARA 0.000107 0.212 up up no no no no 16:0/18:2-PI+blood EPA+blood 0 -0.723039216 0 serum_phospholipids serum_ARA 0.269 0.212 no no no no no no 16:0/20:4-PC+blood EPA+blood 0 0.607843137 0 serum_phospholipids serum_ARA 0.0262 0.212 no up no no no no 16:0/20:4-PE+blood EPA+blood 0 -0.514705882 0 serum_phospholipids serum_ARA 0.00139 0.212 up up no no no no 16:0/20:5-PC+blood EPA+blood 0.673684211 0.674019608 0.491965812 serum_phospholipids serum_ARA 0.628 0.212 no no no no no no 16:0/22:6-PC+blood EPA+blood 0.593984962 0.725490196 0 serum_phospholipids serum_ARA 4.53E-05 0.212 no up up no no no 16:1/18:1-PG+blood EPA+blood 0 -0.5 0 serum_phospholipids serum_ARA 3.21E-05 0.212 no up up no no no 18:0/18:1-PE+blood EPA+blood 0 -0.558823529 0 serum_phospholipids serum_ARA 0.00716 0.212 up up no no no no 18:0/18:1-PI+blood EPA+blood 0 -0.676470588 0 serum_phospholipids serum_ARA 0.599 0.212 no no no no no no 18:0/20:2-PC+blood EPA+blood 0 -0.519607843 0 serum_phospholipids serum_ARA 0.733 0.212 no no no no no no 18:0/20:3-PC+blood EPA+blood 0 -0.647058824 0 serum_phospholipids serum_ARA 0.0682 0.212 no up no no no no 18:0/20:3-PI+blood EPA+blood 0 -0.629901961 0 serum_phospholipids serum_ARA 0.377 0.212 no no no no no no 18:0/20:4-PC+blood EPA+blood 0 0.759803922 0 serum_phospholipids serum_ARA 0.454 0.212 no no no no no no 18:0/20:5-PC+blood EPA+blood 0 0.857843137 0 serum_phospholipids serum_ARA 0.17 0.212 no no no no no no 18:0/22:6-PA+blood EPA+blood 0.595488722 0 0 serum_phospholipids serum_ARA 0.22 0.212 no no no no no no 18:0/22:6-PC+blood EPA+blood 0.545864662 0.512254902 0.437264957 serum_phospholipids serum_ARA 0.0775 0.212 no no up no no no 18:0/22:6-PI+blood EPA+blood 0 0 0.462564103 serum_phospholipids serum_ARA 0.425 0.212 no no no no no no 18:1/16:0-PE+blood EPA+blood 0 -0.698529412 0 serum_phospholipids serum_ARA 0.000182 0.212 up up no no no no 18:1/16:0-PI+blood EPA+blood 0 -0.723039216 0 serum_phospholipids serum_ARA 0.793 0.212 no no no no no no 18:1/16:1-PE+blood EPA+blood 0 -0.754901961 0 serum_phospholipids serum_ARA 0.000184 0.212 up up no no no no 18:1/18:0-PE+blood EPA+blood 0 -0.735294118 0 serum_phospholipids serum_ARA 1.39E-06 0.212 up up no no no no 18:1/18:1-PC+blood EPA+blood 0 -0.62254902 0 serum_phospholipids serum_ARA 1.34E-05 0.212 no up up no no no 18:1/18:1-PE+blood EPA+blood 0 -0.649509804 0 serum_phospholipids serum_ARA 1.03E-05 0.212 up up no no no no 18:1/18:1-PG+blood EPA+blood 0 -0.495098039 0 serum_phospholipids serum_ARA 0.00352 0.212 no up up no no no 18:1/18:1-PI+blood EPA+blood 0 -0.492647059 0 serum_phospholipids serum_ARA 0.111 0.212 dn no no no no no 18:1/18:2-PE+blood EPA+blood -0.526315789 -0.703431373 0 serum_phospholipids serum_ARA 0.000293 0.212 up up no no no no 18:1/20:3-PC+blood EPA+blood 0 0 -0.511111111 serum_phospholipids serum_ARA 0.00872 0.212 no up up no no no 18:1/20:4-PC+blood EPA+blood 0 0.737745098 0 serum_phospholipids serum_ARA 0.582 0.212 no no no no no no 18:2/18:2-PS+blood EPA+blood 0 -0.654411765 0 serum_phospholipids serum_ARA 0.00674 0.212 up up no no no no 18:2/20:4-PC+blood EPA+blood 0 0.541666667 0 serum_phospholipids serum_ARA 0.0145 0.212 no no up no no no 18:3/16:0-PE+blood EPA+blood 0 -0.495098039 0 serum_phospholipids serum_ARA 0.00149 0.212 up up no no no no 18:3n3+blood EPA+blood 0.45112782 0.659313725 0 serum_fattyacid serum_ARA 0.291 0.212 no no no no no no 20:0/20:4-PE+blood EPA+blood 0 -0.526960784 -0.543931624 serum_phospholipids serum_ARA 0.00128 0.212 up up no no no no 20:1/20:4-PC+blood EPA+blood 0.526315789 0 0 serum_phospholipids serum_ARA 0.0419 0.212 no no up no no no 20:2/18:0-PC+blood EPA+blood 0 -0.625 0 serum_phospholipids serum_ARA 0.0427 0.212 no up no no no no 20:2/18:1-PE+blood EPA+blood 0 -0.656862745 -0.410598291 serum_phospholipids serum_ARA 0.00208 0.212 up up no no no no 20:2/18:3-PE+blood EPA+blood 0 0 -0.417435897 serum_phospholipids serum_ARA 0.0391 0.212 up up no no no no 20:2+blood EPA+blood 0 -0.482843137 0 serum_fattyacid serum_ARA 0.478 0.212 no no no no no no 20:3-LPC+blood EPA+blood 0 -0.610294118 0 serum_phospholipids serum_ARA 0.0292 0.212 no up no no no no 20:3-LPE+blood EPA+blood 0 -0.607843137 0 serum_phospholipids serum_ARA 0.084 0.212 no up no no no no 20:3/16:0-PC+blood EPA+blood 0 0.578431373 0 serum_phospholipids serum_ARA 0.00405 0.212 no up up no no no 20:3/18:0-PC+blood EPA+blood 0.464661654 0 0 serum_phospholipids serum_ARA 0.296 0.212 no no no no no no 20:3n6+blood EPA+blood 0 -0.759803922 0 serum_fattyacid serum_ARA 0.0884 0.212 up no no no no no 20:4-LPC+blood EPA+blood 0 0.821078431 0 serum_phospholipids serum_ARA 0.949 0.212 no no no no no no 20:4n6+blood EPA+blood 0 0.75245098 0 serum_fattyacid serum_ARA 0.133 0.212 no no no no no no 20:5-LPC+blood EPA+blood 0.687218045 0.821078431 0.585641026 serum_phospholipids serum_ARA 0.558 0.212 no no no no no no 20:5/18:0-PC+blood EPA+blood 0.610526316 0.607843137 0 serum_phospholipids serum_ARA 3.97E-06 0.212 no up up no no no 20:5n3+blood EPA+blood 0.72481203 0.703431373 0.683418803 serum_fattyacid serum_ARA 0.988 0.212 no no no no no no 22:0/16:0-PE+blood EPA+blood 0.631578947 0 0 serum_phospholipids serum_ARA 0.091 0.212 no no up no no no 22:2-LPA+blood EPA+blood 0 -0.541666667 0 serum_phospholipids serum_ARA 0.0443 0.212 dn no no no no no 22:6-LPC+blood EPA+blood 0 0.759803922 0 serum_phospholipids serum_ARA 0.127 0.212 no no up no no no 22:6n3+blood EPA+blood 0.505263158 0.620098039 0.485811966 serum_fattyacid serum_ARA 0.792 0.212 no no no no no no 4-hydroxybenzoic acid+stool EPA+blood -0.593406593 0 0 stool_cometabolism serum_ARA 0.0536 0.212 no dn no no no no AA+blood EPA+blood 0 0.615196078 0 serum_ARA serum_ARA 0.212 0.212 no no no no no no ACA+blood EPA+blood 0 0.530691844 0 serum_bileacids serum_ARA 0.338 0.212 no no no no no no Adipocytokine signaling pathway EPA+blood -0.464912281 0 0 kegg serum_ARA NA 0.212 no no no no no no Adlercreutzia EPA+blood 0 0 -0.485966179 Genus serum_ARA 0.548 0.212 no no no no no no Anaerostipes EPA+blood 0 0 -0.464575663 butyrate-producing Genus serum_ARA 0.568 0.212 no no no no no no Axon guidance EPA+blood 0 -0.582352941 0 kegg serum_ARA NA 0.212 no up up no no no Betaine+blood EPA+blood -0.610526316 0 0 serum_choline serum_ARA 0.857 0.212 no no no no no no Cholinergic synapse EPA+blood 0 0.505882353 0 kegg serum_ARA NA 0.212 no no no no no no Collinsella EPA+blood 0 0 -0.467056679 Genus serum_ARA 0.128 0.212 no no no no no no d18:0-18:3-SM+blood EPA+blood 0 0 -0.471452991 serum_phospholipids serum_ARA 0.0879 0.212 no dn no no no no d18:1-18:0-SM+blood EPA+blood 0 0.549019608 0 serum_phospholipids serum_ARA 0.97 0.212 no no no no no no d18:1-22:1-SM+blood EPA+blood 0 0 -0.413333333 serum_phospholipids serum_ARA 0.222 0.212 no no no no no no DCA+blood EPA+blood 0 0 0.535042735 serum_bileacids serum_ARA 0.122 0.212 no no no no no no decanoic acid C10+blood EPA+blood 0 -0.816176471 0 serum_mcfa serum_ARA 6.64E-11 0.212 dn dn no no no no DHA+blood EPA+blood 0.613533835 0.620098039 0.624615385 serum_ARA serum_ARA 0.872 0.212 no no no no no no DL-methionine sulfoxide+blood EPA+blood 0 0 0.464615385 serum_aminoacids serum_ARA 0.302 0.212 no no no no no no Gap junction EPA+blood 0 0 -0.439230769 kegg serum_ARA NA 0.212 no no no no no no Glutamatergic synapse EPA+blood 0 0 -0.484615385 kegg serum_ARA NA 0.212 no up up no no no HDCA+stool EPA+blood 0 0 0.476691729 stool_bileacids serum_ARA 0.176 0.212 no no no no no no Insulin resistance EPA+blood 0 0 0.415384615 kegg serum_ARA NA 0.212 no no no no no no Kaposi sarcoma-associated herpesvirus infection EPA+blood 0 -0.635294118 0 kegg serum_ARA NA 0.212 no no dn no no no Long-term potentiation EPA+blood 0.470175439 0 0 kegg serum_ARA NA 0.212 no no up no no no MAPK signaling pathway EPA+blood 0 0.767647059 0 kegg serum_ARA NA 0.212 no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer EPA+blood 0 0 0.539230769 kegg serum_ARA NA 0.212 no no no no no no Primary immunodeficiency EPA+blood 0 0.573529412 0 kegg serum_ARA NA 0.212 no no no no no no Progesterone-mediated oocyte maturation EPA+blood 0 0.5 0 kegg serum_ARA NA 0.212 no no no no no no Regulation of lipolysis in adipocytes EPA+blood 0 0 -0.418461538 kegg serum_ARA NA 0.212 no no no no no no Renal cell carcinoma EPA+blood 0 -0.505882353 0 kegg serum_ARA NA 0.212 no no no no no no Renin secretion EPA+blood 0 0 -0.406153846 kegg serum_ARA NA 0.212 no no no no no no Ruminococcus EPA+blood 0 -0.56127451 0 acetate-producing Genus serum_ARA 0.335 0.212 no no no no no no Salivary secretion EPA+blood 0 0 -0.403076923 kegg serum_ARA NA 0.212 no no no no no no TCA+stool EPA+blood 0 -0.645454545 0 stool_bileacids serum_ARA 0.458 0.212 no no no no no no 2-Oxocarboxylic acid metabolism Epithelial cell signaling in Helicobacter pylori infection 0 -0.641304348 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 0.553359684 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Epithelial cell signaling in Helicobacter pylori infection 0 -0.541501976 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Epithelial cell signaling in Helicobacter pylori infection 0 0.732213439 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Epithelial cell signaling in Helicobacter pylori infection 0 0.721343874 0 kegg kegg NA NA no no no no no no Alcoholism Epithelial cell signaling in Helicobacter pylori infection 0 0 0.411325611 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Epithelial cell signaling in Helicobacter pylori infection 0 -0.687747036 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Epithelial cell signaling in Helicobacter pylori infection 0 0.416007905 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Epithelial cell signaling in Helicobacter pylori infection 0 0.425889328 0 kegg kegg NA NA no no no no no no Alzheimer disease Epithelial cell signaling in Helicobacter pylori infection 0 -0.566205534 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Epithelial cell signaling in Helicobacter pylori infection 0 0 -0.47979408 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Epithelial cell signaling in Helicobacter pylori infection 0 -0.624505929 -0.586872587 kegg kegg NA NA no no no no no no Amphetamine addiction Epithelial cell signaling in Helicobacter pylori infection -0.532173913 -0.846837945 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Epithelial cell signaling in Helicobacter pylori infection -0.422608696 -0.423913043 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Epithelial cell signaling in Helicobacter pylori infection 0 -0.665019763 0 kegg kegg NA NA no no no no no no Antifolate resistance Epithelial cell signaling in Helicobacter pylori infection 0 -0.610671937 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 -0.590909091 0 kegg kegg NA NA no no no no no no Apoptosis Epithelial cell signaling in Helicobacter pylori infection 0.629565217 0.878458498 0.531274131 kegg kegg NA NA no no no no no no Apoptosis - multiple species Epithelial cell signaling in Helicobacter pylori infection -0.426956522 0 -0.724839125 kegg kegg NA NA no no no no no no Arginine and proline metabolism Epithelial cell signaling in Helicobacter pylori infection 0 0.786561265 0.501415701 kegg kegg NA NA no up no no no no Arginine biosynthesis Epithelial cell signaling in Helicobacter pylori infection 0 0.781620553 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Epithelial cell signaling in Helicobacter pylori infection 0 -0.482213439 -0.411325611 kegg kegg NA NA no no no no no no Autophagy - animal Epithelial cell signaling in Helicobacter pylori infection 0 0.636363636 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0.56 0.863636364 0.705019305 kegg kegg NA NA no no no no no no Basal transcription factors Epithelial cell signaling in Helicobacter pylori infection -0.433043478 -0.749011858 -0.612097812 kegg kegg NA NA no no no no no no Base excision repair Epithelial cell signaling in Helicobacter pylori infection -0.48 -0.694664032 -0.73024453 kegg kegg NA NA no no no no no no beta-Alanine metabolism Epithelial cell signaling in Helicobacter pylori infection 0 0 -0.47027027 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Epithelial cell signaling in Helicobacter pylori infection 0 0.804347826 0.415444015 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Epithelial cell signaling in Helicobacter pylori infection -0.509565217 -0.719367589 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Epithelial cell signaling in Helicobacter pylori infection -0.431304348 0 -0.501673102 kegg kegg NA NA no no no no no no Butanoate metabolism Epithelial cell signaling in Helicobacter pylori infection 0 -0.694664032 -0.577606178 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0.54173913 0.878458498 0.641956242 kegg kegg NA NA no no no no no no cAMP signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 0.621541502 0.464092664 yes kegg kegg NA NA no up up no no no Cardiac muscle contraction Epithelial cell signaling in Helicobacter pylori infection 0 -0.542490119 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Epithelial cell signaling in Helicobacter pylori infection 0 0.635375494 0.555727156 kegg kegg NA NA no no no no no no Cell cycle Epithelial cell signaling in Helicobacter pylori infection -0.607826087 -0.864624506 -0.607979408 kegg kegg NA NA no no no no no no Cellular senescence Epithelial cell signaling in Helicobacter pylori infection 0.520869565 0.714426877 0.647361647 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0.453043478 0.83201581 0.611325611 kegg kegg NA NA no no no no no no Chemokine signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0.733913043 0.804347826 0.736164736 kegg kegg NA NA no no no no no no Cholesterol metabolism Epithelial cell signaling in Helicobacter pylori infection 0.446086957 0.559288538 0.491119691 yes kegg kegg NA NA no no up no no no Circadian entrainment Epithelial cell signaling in Helicobacter pylori infection -0.442608696 -0.5256917 0 kegg kegg NA NA no up up no no no Circadian rhythm Epithelial cell signaling in Helicobacter pylori infection 0 -0.630434783 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Epithelial cell signaling in Helicobacter pylori infection -0.46173913 -0.708498024 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Epithelial cell signaling in Helicobacter pylori infection 0.424347826 0.722332016 0 kegg kegg NA NA no no no no no no Cushing syndrome Epithelial cell signaling in Helicobacter pylori infection -0.466956522 -0.57312253 0 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Epithelial cell signaling in Helicobacter pylori infection -0.511304348 -0.681818182 -0.631402831 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Epithelial cell signaling in Helicobacter pylori infection 0.595652174 0.571146245 0.728442728 kegg kegg NA NA no no no no no no DNA replication Epithelial cell signaling in Helicobacter pylori infection -0.58173913 -0.87944664 -0.55032175 kegg kegg NA NA no no no no no no Dopaminergic synapse Epithelial cell signaling in Helicobacter pylori infection 0 -0.586956522 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Epithelial cell signaling in Helicobacter pylori infection 0 -0.786561265 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Epithelial cell signaling in Helicobacter pylori infection 0 -0.645256917 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Epithelial cell signaling in Helicobacter pylori infection -0.607826087 -0.441699605 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Epithelial cell signaling in Helicobacter pylori infection 0 -0.493083004 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Epithelial cell signaling in Helicobacter pylori infection 0 -0.584980237 0 kegg kegg NA NA no no no no no no Endocytosis Epithelial cell signaling in Helicobacter pylori infection 0.516521739 0.666007905 0.705534106 kegg kegg NA NA no no no no no no Estrogen signaling pathway Epithelial cell signaling in Helicobacter pylori infection -0.520869565 -0.795454545 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Epithelial cell signaling in Helicobacter pylori infection 0 -0.679841897 -0.597940798 kegg kegg NA NA no no no no no no Fanconi anemia pathway Epithelial cell signaling in Helicobacter pylori infection -0.544347826 -0.674901186 -0.717374517 kegg kegg NA NA no no no no no no Fat digestion and absorption Epithelial cell signaling in Helicobacter pylori infection 0 0.596837945 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Epithelial cell signaling in Helicobacter pylori infection 0 0.747035573 0 kegg kegg NA NA no no no no no no Fatty acid degradation Epithelial cell signaling in Helicobacter pylori infection 0 0.470355731 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Epithelial cell signaling in Helicobacter pylori infection 0 0.466403162 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 0.856719368 0.420592021 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Epithelial cell signaling in Helicobacter pylori infection 0.433913043 0.736166008 0 kegg kegg NA NA no no no no no no Folate biosynthesis Epithelial cell signaling in Helicobacter pylori infection 0 -0.518774704 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 0 -0.581724582 kegg kegg NA NA no no no no no no GABAergic synapse Epithelial cell signaling in Helicobacter pylori infection 0 0.587944664 0 kegg kegg NA NA no up up no no no Galactose metabolism Epithelial cell signaling in Helicobacter pylori infection 0 0.422924901 0 kegg kegg NA NA no no no no no no Gastric acid secretion Epithelial cell signaling in Helicobacter pylori infection 0 -0.486166008 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Epithelial cell signaling in Helicobacter pylori infection -0.626956522 -0.833992095 0 kegg kegg NA NA no no no no no no Glutathione metabolism Epithelial cell signaling in Helicobacter pylori infection -0.467826087 -0.643280632 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Epithelial cell signaling in Helicobacter pylori infection 0 0 -0.464864865 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Epithelial cell signaling in Helicobacter pylori infection -0.48173913 -0.527667984 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Epithelial cell signaling in Helicobacter pylori infection 0.677391304 0.604743083 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Epithelial cell signaling in Helicobacter pylori infection 0 -0.531620553 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Epithelial cell signaling in Helicobacter pylori infection 0.712173913 0.48715415 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Epithelial cell signaling in Helicobacter pylori infection 0 -0.608695652 -0.532818533 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Epithelial cell signaling in Helicobacter pylori infection 0 -0.4743083 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Epithelial cell signaling in Helicobacter pylori infection 0 0.803359684 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 -0.674901186 -0.410553411 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Epithelial cell signaling in Helicobacter pylori infection 0 0 -0.432175032 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 -0.418972332 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 -0.504940711 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Epithelial cell signaling in Helicobacter pylori infection 0.520869565 0.531620553 0 kegg kegg NA NA no no no no no no Homologous recombination Epithelial cell signaling in Helicobacter pylori infection -0.435652174 -0.424901186 -0.807464607 kegg kegg NA NA no no no no no no Huntington disease Epithelial cell signaling in Helicobacter pylori infection 0 -0.579051383 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0.744347826 0.836956522 0.700643501 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Epithelial cell signaling in Helicobacter pylori infection 0 -0.720355731 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Epithelial cell signaling in Helicobacter pylori infection 0 0 -0.585842986 kegg kegg NA NA no no no no no no Insulin resistance Epithelial cell signaling in Helicobacter pylori infection 0 0.614624506 0 kegg kegg NA NA no no no no no no Insulin secretion Epithelial cell signaling in Helicobacter pylori infection 0 -0.420948617 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 -0.561264822 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 0.434782609 0 kegg kegg NA NA no no no no no no Long-term potentiation Epithelial cell signaling in Helicobacter pylori infection 0 -0.517786561 0 kegg kegg NA NA no no up no no no Lysine degradation Epithelial cell signaling in Helicobacter pylori infection 0 -0.427865613 -0.405920206 kegg kegg NA NA no no no no no no Lysosome Epithelial cell signaling in Helicobacter pylori infection 0.722608696 0.730237154 0.515830116 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Epithelial cell signaling in Helicobacter pylori infection 0 -0.437747036 0 kegg kegg NA NA no up no no no no Melanogenesis Epithelial cell signaling in Helicobacter pylori infection -0.520869565 -0.65513834 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Epithelial cell signaling in Helicobacter pylori infection 0 -0.708498024 0 kegg kegg NA NA no no no no no no Mismatch repair Epithelial cell signaling in Helicobacter pylori infection -0.449565217 -0.758893281 -0.553667954 kegg kegg NA NA no no no no no no Morphine addiction Epithelial cell signaling in Helicobacter pylori infection 0 -0.456521739 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Epithelial cell signaling in Helicobacter pylori infection 0 -0.711462451 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 -0.484189723 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Epithelial cell signaling in Helicobacter pylori infection -0.61826087 -0.853754941 -0.576576577 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Epithelial cell signaling in Helicobacter pylori infection 0.514782609 0.690711462 0.663835264 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Epithelial cell signaling in Helicobacter pylori infection 0.413913043 0.640316206 0.53024453 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0.47826087 0.751976285 0.668983269 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Epithelial cell signaling in Helicobacter pylori infection 0.588695652 0.73715415 0.532046332 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0.482608696 0.710474308 0.455598456 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Epithelial cell signaling in Helicobacter pylori infection 0.497391304 0.780632411 0.568339768 kegg kegg NA NA no no no no no no Nitrogen metabolism Epithelial cell signaling in Helicobacter pylori infection 0.567826087 0.750988142 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0.550434783 0.824110672 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Epithelial cell signaling in Helicobacter pylori infection 0 -0.481225296 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Epithelial cell signaling in Helicobacter pylori infection -0.640869565 -0.865612648 -0.797683398 kegg kegg NA NA no no no no no no Olfactory transduction Epithelial cell signaling in Helicobacter pylori infection 0 0.636363636 0 kegg kegg NA NA no no no no no no One carbon pool by folate Epithelial cell signaling in Helicobacter pylori infection -0.72 -0.910079051 -0.677734878 kegg kegg NA NA no no no no no no Oocyte meiosis Epithelial cell signaling in Helicobacter pylori infection -0.507826087 -0.555335968 -0.426254826 kegg kegg NA NA no no no no no no Osteoclast differentiation Epithelial cell signaling in Helicobacter pylori infection 0.769565217 0.878458498 0.775289575 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Epithelial cell signaling in Helicobacter pylori infection 0 -0.481225296 -0.604118404 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Epithelial cell signaling in Helicobacter pylori infection -0.486956522 0 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Epithelial cell signaling in Helicobacter pylori infection 0 -0.54743083 0 kegg kegg NA NA no no no no no no p53 signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 0 -0.683655084 kegg kegg NA NA no no no no no no Pancreatic secretion Epithelial cell signaling in Helicobacter pylori infection 0 -0.513833992 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Epithelial cell signaling in Helicobacter pylori infection 0.487826087 0.640316206 0 kegg kegg NA NA no no dn no no no Paraprevotella Epithelial cell signaling in Helicobacter pylori infection 0 -0.43181515 0 Genus kegg 0.118 NA no no no no no no Parkinson disease Epithelial cell signaling in Helicobacter pylori infection 0 -0.496047431 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Epithelial cell signaling in Helicobacter pylori infection 0 -0.514822134 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Epithelial cell signaling in Helicobacter pylori infection -0.412173913 -0.785573123 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Epithelial cell signaling in Helicobacter pylori infection 0.685217391 0.764822134 0.446074646 kegg kegg NA NA no no no no no no Peroxisome Epithelial cell signaling in Helicobacter pylori infection 0 0.601778656 0 kegg kegg NA NA no no no no no no Phagosome Epithelial cell signaling in Helicobacter pylori infection 0.436521739 0.707509881 0.624195624 kegg kegg NA NA no no no no no no Phenylalanine metabolism Epithelial cell signaling in Helicobacter pylori infection 0 -0.605731225 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Epithelial cell signaling in Helicobacter pylori infection 0 -0.621541502 -0.471042471 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0.475652174 0.602766798 0.410810811 kegg kegg NA NA no up up no no no Phototransduction Epithelial cell signaling in Helicobacter pylori infection -0.444347826 0 -0.441441441 kegg kegg NA NA no no no no no no Platinum drug resistance Epithelial cell signaling in Helicobacter pylori infection 0 0 -0.768082368 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Epithelial cell signaling in Helicobacter pylori infection -0.416521739 -0.484189723 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0.594782609 0.854743083 0.846074646 kegg kegg NA NA no no no no no no Prevotella Epithelial cell signaling in Helicobacter pylori infection -0.504374875 0 0 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Epithelial cell signaling in Helicobacter pylori infection -0.499130435 0 0 kegg kegg NA NA no no no no no no Prion disease Epithelial cell signaling in Helicobacter pylori infection 0 -0.574110672 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 0.705533597 0 kegg kegg NA NA no no no no no no Propanoate metabolism Epithelial cell signaling in Helicobacter pylori infection 0 -0.617588933 -0.560617761 kegg kegg NA NA no no no no no no Proteasome Epithelial cell signaling in Helicobacter pylori infection 0 -0.497035573 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Epithelial cell signaling in Helicobacter pylori infection 0 0.460474308 0 yes kegg kegg NA NA no up up no no no Protein export Epithelial cell signaling in Helicobacter pylori infection -0.454782609 -0.657114625 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Epithelial cell signaling in Helicobacter pylori infection -0.564347826 -0.815217391 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Epithelial cell signaling in Helicobacter pylori infection -0.63826087 -0.840909091 -0.573487773 kegg kegg NA NA no no no no no no Purine metabolism Epithelial cell signaling in Helicobacter pylori infection 0 -0.545454545 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Epithelial cell signaling in Helicobacter pylori infection 0 -0.800395257 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Epithelial cell signaling in Helicobacter pylori infection -0.54173913 -0.745059289 -0.644272844 kegg kegg NA NA no no no no no no Ras signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 -0.637351779 0 yes kegg kegg NA NA no up up no no no Relaxin signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 0.603754941 0.504247104 kegg kegg NA NA no no no no no no Renin secretion Epithelial cell signaling in Helicobacter pylori infection -0.553913043 -0.691699605 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Epithelial cell signaling in Helicobacter pylori infection 0.453043478 0.764822134 0.4002574 kegg kegg NA NA no no no no no no Retinol metabolism Epithelial cell signaling in Helicobacter pylori infection 0 -0.632411067 -0.536164736 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Epithelial cell signaling in Helicobacter pylori infection 0 -0.555335968 0 kegg kegg NA NA no no up no no no Ribosome Epithelial cell signaling in Helicobacter pylori infection 0 -0.516798419 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Epithelial cell signaling in Helicobacter pylori infection -0.591304348 -0.837944664 -0.638095238 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0.586086957 0.733201581 0.542084942 kegg kegg NA NA no no no no no no RNA degradation Epithelial cell signaling in Helicobacter pylori infection 0 -0.785573123 0 kegg kegg NA NA no no no no no no RNA polymerase Epithelial cell signaling in Helicobacter pylori infection -0.511304348 -0.888339921 -0.582239382 kegg kegg NA NA no no no no no no Selenocompound metabolism Epithelial cell signaling in Helicobacter pylori infection 0 -0.441699605 -0.683912484 kegg kegg NA NA no no no no no no Serotonergic synapse Epithelial cell signaling in Helicobacter pylori infection 0 0 0.415186615 kegg kegg NA NA no no no no no no Sphingolipid metabolism Epithelial cell signaling in Helicobacter pylori infection 0.590434783 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 0.657114625 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Epithelial cell signaling in Helicobacter pylori infection 0 -0.665019763 0 kegg kegg NA NA no no no no no no Spliceosome Epithelial cell signaling in Helicobacter pylori infection 0 0 -0.492406692 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Epithelial cell signaling in Helicobacter pylori infection 0.443478261 0.627470356 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Epithelial cell signaling in Helicobacter pylori infection -0.642608696 -0.696640316 -0.644272844 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Epithelial cell signaling in Helicobacter pylori infection 0 -0.635375494 -0.404633205 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Epithelial cell signaling in Helicobacter pylori infection 0.519130435 0.671936759 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Epithelial cell signaling in Helicobacter pylori infection -0.579130435 -0.794466403 -0.622136422 kegg kegg NA NA no no no no no no Taste transduction Epithelial cell signaling in Helicobacter pylori infection -0.531304348 -0.756916996 -0.497554698 kegg kegg NA NA no no up no no no Terpenoid backbone biosynthesis Epithelial cell signaling in Helicobacter pylori infection -0.517391304 -0.541501976 -0.47953668 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 -0.566205534 0 kegg kegg NA NA no no no no no no Thermogenesis Epithelial cell signaling in Helicobacter pylori infection 0 -0.606719368 0 kegg kegg NA NA no no no no no no Thiamine metabolism Epithelial cell signaling in Helicobacter pylori infection 0 -0.528656126 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Epithelial cell signaling in Helicobacter pylori infection -0.568695652 0 0 kegg kegg NA NA no no no no no no TNF signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0.497391304 0.761857708 0.716602317 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0.706086957 0.92687747 0.919433719 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Epithelial cell signaling in Helicobacter pylori infection 0 -0.490118577 -0.432175032 kegg kegg NA NA no up no no no no Type I diabetes mellitus Epithelial cell signaling in Helicobacter pylori infection 0 0.572134387 0.53951094 kegg kegg NA NA no no no no no no Type II diabetes mellitus Epithelial cell signaling in Helicobacter pylori infection 0 0.418972332 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Epithelial cell signaling in Helicobacter pylori infection -0.505217391 -0.746047431 -0.585842986 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Epithelial cell signaling in Helicobacter pylori infection -0.471304348 -0.703557312 -0.643500644 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Epithelial cell signaling in Helicobacter pylori infection 0 -0.523715415 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Epithelial cell signaling in Helicobacter pylori infection -0.474782609 -0.739130435 -0.624453024 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Epithelial cell signaling in Helicobacter pylori infection 0 -0.726284585 -0.434749035 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Epithelial cell signaling in Helicobacter pylori infection 0 -0.480237154 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Epithelial cell signaling in Helicobacter pylori infection 0 -0.587944664 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 0.544466403 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Epithelial cell signaling in Helicobacter pylori infection 0.446086957 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Epithelial cell signaling in Helicobacter pylori infection 0 -0.825098814 0 kegg kegg NA NA no no no no no no ABC transporters Epstein-Barr virus infection 0 -0.506916996 0 kegg kegg NA NA no up up no no no Alcoholism Epstein-Barr virus infection 0.536521739 0 0.407722008 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Epstein-Barr virus infection 0 -0.463438735 -0.416731017 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Epstein-Barr virus infection 0 -0.471343874 0 kegg kegg NA NA no no no no no no Antifolate resistance Epstein-Barr virus infection -0.659130435 -0.687747036 -0.453539254 kegg kegg NA NA no no no no no no Antigen processing and presentation Epstein-Barr virus infection 0.959130435 0.968379447 0.905019305 kegg kegg NA NA no no no no no no Apoptosis - multiple species Epstein-Barr virus infection 0 -0.540513834 -0.538223938 kegg kegg NA NA no no no no no no Axon guidance Epstein-Barr virus infection 0.496521739 0.501976285 0 kegg kegg NA NA no up up no no no Base excision repair Epstein-Barr virus infection 0 -0.54743083 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Epstein-Barr virus infection 0 -0.455533597 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Epstein-Barr virus infection 0.471304348 0.517786561 0.723294723 kegg kegg NA NA no no no no no no Cell cycle Epstein-Barr virus infection 0 -0.484189723 0 kegg kegg NA NA no no no no no no Cellular senescence Epstein-Barr virus infection 0.643478261 0.45256917 0.692149292 kegg kegg NA NA no no no no no no Cholesterol metabolism Epstein-Barr virus infection 0.566086957 0.586956522 0 yes kegg kegg NA NA no no up no no no Clostridium Epstein-Barr virus infection 0 0.415672633 0 Genus kegg 0.925 NA no no no no no no Cocaine addiction Epstein-Barr virus infection 0 -0.421936759 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Epstein-Barr virus infection -0.433913043 -0.540513834 0 kegg kegg NA NA no no up no no no Cushing syndrome Epstein-Barr virus infection -0.490434783 -0.52173913 0 kegg kegg NA NA no no up no no no Cytosolic DNA-sensing pathway Epstein-Barr virus infection 0 0 0.413899614 kegg kegg NA NA no no no no no no Endocrine resistance Epstein-Barr virus infection -0.549565217 -0.653162055 -0.431660232 kegg kegg NA NA no no no no no no Endocytosis Epstein-Barr virus infection 0.6 0.524703557 0.718661519 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Epstein-Barr virus infection 0 0 0.52998713 kegg kegg NA NA no no no no no no Ether lipid metabolism Epstein-Barr virus infection -0.435652174 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Epstein-Barr virus infection 0 -0.631422925 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Epstein-Barr virus infection 0 0 -0.431145431 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Epstein-Barr virus infection 0 -0.562252964 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Epstein-Barr virus infection 0 -0.596837945 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Epstein-Barr virus infection -0.691304348 -0.65513834 -0.419305019 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Epstein-Barr virus infection 0 -0.467391304 0 kegg kegg NA NA no up no no no no Glycosphingolipid biosynthesis - ganglio series Epstein-Barr virus infection 0 0 -0.451480051 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Epstein-Barr virus infection -0.464347826 -0.561264822 -0.412612613 kegg kegg NA NA no no no no no no GnRH signaling pathway Epstein-Barr virus infection 0 -0.416996047 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Epstein-Barr virus infection 0 -0.531620553 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Epstein-Barr virus infection -0.474782609 -0.652173913 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Epstein-Barr virus infection 0.952173913 0.966403162 0.948005148 kegg kegg NA NA no no no no no no Homologous recombination Epstein-Barr virus infection 0 -0.553359684 0 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Epstein-Barr virus infection 0.975652174 0.97826087 0.945431145 kegg kegg NA NA no no dn no no no Human papillomavirus infection Epstein-Barr virus infection 0.547826087 0 0.636036036 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Epstein-Barr virus infection 0.965217391 0.988142292 0.952638353 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Epstein-Barr virus infection -0.586086957 -0.599802372 -0.595624196 kegg kegg NA NA no no no no no no Insulin secretion Epstein-Barr virus infection -0.460869565 -0.429841897 0 yes kegg kegg NA NA no up up no no no JAK-STAT signaling pathway Epstein-Barr virus infection -0.426956522 0 0 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection 0 0.514822134 0 kegg kegg NA NA no no dn no no no Leukocyte transendothelial migration Epstein-Barr virus infection 0 0.524703557 0 kegg kegg NA NA no no no no no no Lysine degradation Epstein-Barr virus infection 0 -0.631422925 0 kegg kegg NA NA no no no no no no Lysosome Epstein-Barr virus infection 0 0.53458498 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Epstein-Barr virus infection 0 -0.453557312 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Epstein-Barr virus infection 0 -0.508893281 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Epstein-Barr virus infection 0.643478261 0.516798419 0.751608752 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Epstein-Barr virus infection 0 0.528656126 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Epstein-Barr virus infection 0 0 0.428314028 kegg kegg NA NA no no no no no no Nicotine addiction Epstein-Barr virus infection 0 -0.65513834 0 kegg kegg NA NA no up up no no no Notch signaling pathway Epstein-Barr virus infection 0 -0.524703557 0 kegg kegg NA NA no no no no no no One carbon pool by folate Epstein-Barr virus infection -0.453043478 -0.493083004 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Epstein-Barr virus infection 0 -0.664031621 -0.467181467 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Epstein-Barr virus infection -0.523478261 0 0 kegg kegg NA NA no up up no no no p53 signaling pathway Epstein-Barr virus infection 0 -0.493083004 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Epstein-Barr virus infection 0 0.476284585 0 kegg kegg NA NA no no no no no no Pertussis Epstein-Barr virus infection 0 0.425889328 0.419305019 kegg kegg NA NA no no dn no no no Phagosome Epstein-Barr virus infection 0.457391304 0.518774704 0.621879022 kegg kegg NA NA no no no no no no Phenylalanine metabolism Epstein-Barr virus infection 0 0 -0.410810811 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Epstein-Barr virus infection 0 0 -0.415186615 kegg kegg NA NA no no no no no no Phototransduction Epstein-Barr virus infection 0 0.467391304 0 kegg kegg NA NA no no no no no no Platinum drug resistance Epstein-Barr virus infection 0 -0.602766798 -0.537451737 kegg kegg NA NA no no no no no no PPAR signaling pathway Epstein-Barr virus infection 0.54173913 0 0.485456885 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Epstein-Barr virus infection 0 -0.600790514 0 kegg kegg NA NA no no no no no no Proteasome Epstein-Barr virus infection 0.415652174 0 0.499099099 kegg kegg NA NA no no no no no no Purine metabolism Epstein-Barr virus infection 0 -0.464426877 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Epstein-Barr virus infection 0.422608696 0 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Epstein-Barr virus infection 0 0.489130435 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Epstein-Barr virus infection 0 -0.461462451 0 kegg kegg NA NA no no no no no no Salmonella infection Epstein-Barr virus infection 0 0.499011858 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Epstein-Barr virus infection 0 -0.679841897 -0.423423423 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Epstein-Barr virus infection 0 -0.437747036 -0.427799228 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Epstein-Barr virus infection 0 0.496047431 0 kegg kegg NA NA no no no no no no Spliceosome Epstein-Barr virus infection 0 -0.494071146 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Epstein-Barr virus infection 0 0.48715415 0 kegg kegg NA NA up no no no no no Steroid biosynthesis Epstein-Barr virus infection -0.434782609 0 0 kegg kegg NA NA no no no no no no Taste transduction Epstein-Barr virus infection 0 -0.475296443 -0.483397683 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Epstein-Barr virus infection -0.457391304 -0.610671937 0 kegg kegg NA NA no no no no no no Tuberculosis Epstein-Barr virus infection 0 0.460474308 0 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Epstein-Barr virus infection 0.475652174 0.531620553 0.739253539 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Epstein-Barr virus infection -0.440869565 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Epstein-Barr virus infection 0.422608696 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Epstein-Barr virus infection -0.42 -0.421936759 0 kegg kegg NA NA no no no no no no ABC transporters ErbB signaling pathway 0 0.583003953 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism ErbB signaling pathway -0.405217391 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism ErbB signaling pathway -0.629565217 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism ErbB signaling pathway -0.563478261 0 -0.682368082 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism ErbB signaling pathway -0.437391304 -0.511857708 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism ErbB signaling pathway -0.514782609 -0.605731225 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids ErbB signaling pathway 0 0 -0.433976834 kegg kegg NA NA no no no no no no Biosynthesis of cofactors ErbB signaling pathway -0.534782609 0 -0.443243243 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids ErbB signaling pathway -0.462608696 -0.546442688 0 kegg kegg NA NA no no no no no no Butanoate metabolism ErbB signaling pathway -0.483478261 -0.485177866 0 kegg kegg NA NA no no no no no no Carbon metabolism ErbB signaling pathway -0.520869565 -0.451581028 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) ErbB signaling pathway -0.506086957 -0.597826087 0 kegg kegg NA NA no no no no no no Clostridium ErbB signaling pathway 0 -0.503289904 0 Genus kegg 0.925 NA no no no no no no Collinsella ErbB signaling pathway 0 0 -0.518591333 Genus kegg 0.128 NA no no no no no no Cysteine and methionine metabolism ErbB signaling pathway -0.455652174 -0.500988142 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 ErbB signaling pathway -0.584347826 -0.572134387 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes ErbB signaling pathway -0.643478261 -0.60770751 0 kegg kegg NA NA no no no no no no Endocrine resistance ErbB signaling pathway 0.435652174 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation ErbB signaling pathway -0.527826087 -0.556324111 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism ErbB signaling pathway -0.426086957 0.508893281 0 kegg kegg NA NA no no no no no no Galactose metabolism ErbB signaling pathway 0 0.42687747 0 kegg kegg NA NA no no no no no no Gemmiger ErbB signaling pathway 0 0.449060556 0 butyrate-producing Genus kegg 0.595 NA no no no no no no Glutathione metabolism ErbB signaling pathway -0.406956522 0 -0.665379665 kegg kegg NA NA no no no no no no Glycerolipid metabolism ErbB signaling pathway 0 0.633399209 0.566795367 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism ErbB signaling pathway 0 0.46541502 0.555727156 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" ErbB signaling pathway 0 0 -0.408494208 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis ErbB signaling pathway -0.599130435 -0.648221344 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate ErbB signaling pathway 0 0.753952569 0.534877735 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin ErbB signaling pathway 0 0 0.431145431 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate ErbB signaling pathway 0.51826087 0 0.453539254 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series ErbB signaling pathway -0.477391304 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series ErbB signaling pathway 0.553043478 0 0.416731017 kegg kegg NA NA no no no no no no Histidine metabolism ErbB signaling pathway -0.445217391 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism ErbB signaling pathway 0 0.585968379 0.598198198 kegg kegg NA NA no no no no no no Lachnospira ErbB signaling pathway 0 -0.51791452 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Linoleic acid metabolism ErbB signaling pathway -0.572173913 0 0 kegg kegg NA NA no no no no no no Lysine degradation ErbB signaling pathway 0.411304348 0.503952569 0.651480051 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis ErbB signaling pathway 0.625217391 0.506916996 0.61029601 kegg kegg NA NA no no no no no no MAPK signaling pathway ErbB signaling pathway 0 0 0.792277992 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 ErbB signaling pathway -0.619130435 -0.638339921 0 kegg kegg NA NA no no no no no no Mismatch repair ErbB signaling pathway -0.453913043 -0.416996047 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway ErbB signaling pathway 0.46 0 0.57014157 kegg kegg NA NA no no no no no no N-Glycan biosynthesis ErbB signaling pathway 0 0 0.442213642 kegg kegg NA NA no no no no no no Non-homologous end-joining ErbB signaling pathway -0.472173913 -0.509881423 0 kegg kegg NA NA no no no no no no Other glycan degradation ErbB signaling pathway 0 0.477272727 0.525868726 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis ErbB signaling pathway 0 0.501976285 0.620849421 kegg kegg NA NA no no no no no no Oxidative phosphorylation ErbB signaling pathway 0 -0.449604743 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions ErbB signaling pathway -0.689565217 -0.479249012 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism ErbB signaling pathway -0.547826087 -0.540513834 0 kegg kegg NA NA no no no no no no Platinum drug resistance ErbB signaling pathway 0.500869565 0.549407115 0.459202059 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism ErbB signaling pathway 0 0 -0.47979408 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis ErbB signaling pathway -0.492173913 -0.671936759 0 kegg kegg NA NA no no no no no no Propanoate metabolism ErbB signaling pathway -0.500869565 -0.528656126 0 kegg kegg NA NA no no no no no no Proteasome ErbB signaling pathway 0 -0.704545455 0 kegg kegg NA NA no no no no no no Protein export ErbB signaling pathway 0 -0.496047431 0 kegg kegg NA NA no no no no no no Purine metabolism ErbB signaling pathway 0 0 -0.446074646 kegg kegg NA NA no no no no no no Pyrimidine metabolism ErbB signaling pathway -0.428695652 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism ErbB signaling pathway -0.469565217 -0.531620553 0 kegg kegg NA NA no no no no no no Retinol metabolism ErbB signaling pathway -0.517391304 0 0 kegg kegg NA NA no no no no no no Ribosome ErbB signaling pathway 0 -0.420948617 0 kegg kegg NA NA no no no no no no RNA degradation ErbB signaling pathway 0.483478261 0 0.554697555 kegg kegg NA NA no no no no no no Ruminococcus ErbB signaling pathway 0 -0.547302322 0 Genus kegg 0.0679 NA no no dn no no no Spliceosome ErbB signaling pathway 0 0.520750988 0.548777349 kegg kegg NA NA no no no no no no Steroid biosynthesis ErbB signaling pathway 0 -0.571146245 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis ErbB signaling pathway -0.742608696 -0.470355731 0 kegg kegg NA NA no no no no no no Sulfur metabolism ErbB signaling pathway -0.544347826 -0.440711462 -0.53024453 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism ErbB signaling pathway 0.512173913 0.734189723 0.418018018 kegg kegg NA NA no no no no no no Thiamine metabolism ErbB signaling pathway -0.433043478 -0.455533597 0 kegg kegg NA NA no no no no no no Tryptophan metabolism ErbB signaling pathway -0.520869565 -0.618577075 0 kegg kegg NA NA no up no no no no Tyrosine metabolism ErbB signaling pathway -0.606086957 -0.509881423 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis ErbB signaling pathway -0.536521739 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" ErbB signaling pathway -0.470434783 -0.486166008 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis ErbB signaling pathway 0 0 0.48957529 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Estrogen signaling pathway 0 0.551383399 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Estrogen signaling pathway 0 -0.532608696 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Estrogen signaling pathway 0 0.420948617 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Estrogen signaling pathway 0 0.710474308 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Estrogen signaling pathway 0 0 0.465894466 kegg kegg NA NA no no no no no no Antifolate resistance Estrogen signaling pathway 0 0.498023715 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Estrogen signaling pathway 0 0.416007905 0 kegg kegg NA NA no no no no no no Apoptosis Estrogen signaling pathway 0 -0.697628458 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Estrogen signaling pathway 0 -0.599802372 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Estrogen signaling pathway 0 -0.566205534 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Estrogen signaling pathway 0 0.606719368 0 kegg kegg NA NA no no no no no no Autophagy - animal Estrogen signaling pathway 0 -0.621541502 0 kegg kegg NA NA no no no no no no Axon guidance Estrogen signaling pathway 0 -0.486166008 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Estrogen signaling pathway -0.609565217 -0.778656126 -0.585585586 kegg kegg NA NA no no no no no no Basal transcription factors Estrogen signaling pathway 0 0.714426877 0 kegg kegg NA NA no no no no no no Base excision repair Estrogen signaling pathway 0 0.488142292 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Estrogen signaling pathway 0 0.555335968 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Estrogen signaling pathway 0 -0.528656126 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Estrogen signaling pathway 0 0.608695652 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Estrogen signaling pathway 0.58173913 0.454545455 0.441956242 kegg kegg NA NA no no no no no no Butanoate metabolism Estrogen signaling pathway 0 0.727272727 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Estrogen signaling pathway -0.468695652 -0.818181818 -0.501415701 kegg kegg NA NA no no no no no no cAMP signaling pathway Estrogen signaling pathway 0 -0.627470356 0 yes kegg kegg NA NA no up up no no no Cell adhesion molecules Estrogen signaling pathway 0 -0.527667984 0 kegg kegg NA NA no no no no no no Cell cycle Estrogen signaling pathway 0.596521739 0.658102767 0 kegg kegg NA NA no no no no no no Cellular senescence Estrogen signaling pathway 0 -0.662055336 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Estrogen signaling pathway 0 -0.568181818 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Estrogen signaling pathway 0 -0.77173913 0 kegg kegg NA NA no no no no no no Circadian entrainment Estrogen signaling pathway 0.613913043 0.590909091 0.635263835 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Estrogen signaling pathway 0.425217391 0.723320158 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Estrogen signaling pathway 0 -0.575098814 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Estrogen signaling pathway 0.723478261 0.624505929 0.504504505 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Estrogen signaling pathway 0 -0.684782609 0 kegg kegg NA NA no no no no no no DNA replication Estrogen signaling pathway 0.496521739 0.752964427 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Estrogen signaling pathway 0 0.437747036 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Estrogen signaling pathway 0 0.721343874 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Estrogen signaling pathway 0 0.611660079 -0.536679537 kegg kegg NA NA no no no no no no ECM-receptor interaction Estrogen signaling pathway 0.562608696 0 0 kegg kegg NA NA no up up no no no Endocrine resistance Estrogen signaling pathway 0 0 0.485199485 kegg kegg NA NA no no no no no no Endocytosis Estrogen signaling pathway 0 -0.538537549 -0.415701416 kegg kegg NA NA no no no no no no ErbB signaling pathway Estrogen signaling pathway 0 -0.4743083 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Estrogen signaling pathway 0 0.668972332 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Estrogen signaling pathway 0.54173913 0.613636364 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Estrogen signaling pathway 0 -0.526679842 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Estrogen signaling pathway -0.470434783 -0.692687747 -0.55032175 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Estrogen signaling pathway 0 -0.457509881 0 kegg kegg NA NA no no no no no no Focal adhesion Estrogen signaling pathway 0 0.422924901 0 kegg kegg NA NA no up up no no no Fructose and mannose metabolism Estrogen signaling pathway 0 0 -0.490862291 kegg kegg NA NA no no no no no no GABAergic synapse Estrogen signaling pathway 0 -0.497035573 0 kegg kegg NA NA no up up no no no Galactose metabolism Estrogen signaling pathway 0 0 -0.532046332 kegg kegg NA NA no no no no no no Gap junction Estrogen signaling pathway 0 0 0.596653797 kegg kegg NA NA no no no no no no Glutamatergic synapse Estrogen signaling pathway 0 0 0.448648649 kegg kegg NA NA no up up no no no Glycerolipid metabolism Estrogen signaling pathway 0 0 -0.483397683 kegg kegg NA NA no no up no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Estrogen signaling pathway -0.530434783 -0.576086957 -0.551093951 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Estrogen signaling pathway 0 0.422924901 -0.407722008 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Estrogen signaling pathway -0.516521739 0 -0.673616474 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Estrogen signaling pathway 0 0.623517787 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Estrogen signaling pathway -0.517391304 0 -0.459202059 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Estrogen signaling pathway 0 -0.597826087 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Estrogen signaling pathway 0 0 0.410553411 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Estrogen signaling pathway 0 0.601778656 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Estrogen signaling pathway 0 0.471343874 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Estrogen signaling pathway 0 0 -0.621879022 kegg kegg NA NA no no no no no no Homologous recombination Estrogen signaling pathway 0.575652174 0 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Estrogen signaling pathway 0 -0.619565217 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Estrogen signaling pathway 0 0.572134387 0.607207207 kegg kegg NA NA no no no no no no Long-term potentiation Estrogen signaling pathway 0 0.56916996 0 kegg kegg NA NA no no up no no no Longevity regulating pathway - multiple species Estrogen signaling pathway 0.668695652 0 0.574774775 kegg kegg NA NA no no no no no no Lysosome Estrogen signaling pathway -0.584347826 -0.5 -0.488803089 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Estrogen signaling pathway -0.513913043 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Estrogen signaling pathway 0.475652174 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Estrogen signaling pathway 0 0.71541502 0 kegg kegg NA NA no no no no no no Mismatch repair Estrogen signaling pathway 0.61826087 0.754940711 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Estrogen signaling pathway 0 0.423913043 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Estrogen signaling pathway 0.649565217 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Estrogen signaling pathway 0 0.666007905 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Estrogen signaling pathway 0 -0.574110672 -0.406435006 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Estrogen signaling pathway 0 -0.849802372 -0.478249678 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Estrogen signaling pathway 0 -0.472332016 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Estrogen signaling pathway 0 -0.696640316 -0.404118404 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Estrogen signaling pathway 0 -0.58201581 -0.425225225 kegg kegg NA NA no no no no no no Nitrogen metabolism Estrogen signaling pathway 0 -0.616600791 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Estrogen signaling pathway 0 -0.652173913 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Estrogen signaling pathway 0.413913043 0.511857708 0.41956242 kegg kegg NA NA no no no no no no Notch signaling pathway Estrogen signaling pathway -0.451304348 0 -0.475160875 kegg kegg NA NA no no no no no no Nucleotide excision repair Estrogen signaling pathway 0.545217391 0.829051383 0 kegg kegg NA NA no no no no no no One carbon pool by folate Estrogen signaling pathway 0.630434783 0.852766798 0 kegg kegg NA NA no no no no no no Oocyte meiosis Estrogen signaling pathway 0.453913043 0.578063241 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Estrogen signaling pathway 0 -0.658102767 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Estrogen signaling pathway 0.473043478 0 0.493178893 kegg kegg NA NA no up up no no no Pentose and glucuronate interconversions Estrogen signaling pathway 0.571304348 0.751976285 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Estrogen signaling pathway 0 -0.504940711 0 kegg kegg NA NA no no no no no no Peroxisome Estrogen signaling pathway 0 -0.415019763 0 kegg kegg NA NA no no no no no no Phagosome Estrogen signaling pathway 0 -0.529644269 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Estrogen signaling pathway 0 0.757905138 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Estrogen signaling pathway 0 0.506916996 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Estrogen signaling pathway 0 -0.527667984 0 kegg kegg NA NA no up up no no no Phototransduction Estrogen signaling pathway 0 0.495059289 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Estrogen signaling pathway 0 -0.703557312 0 kegg kegg NA NA no no no no no no Prevotella Estrogen signaling pathway 0.420878745 0 0 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Estrogen signaling pathway 0.555652174 0.56027668 0 kegg kegg NA NA no no no no no no Propanoate metabolism Estrogen signaling pathway 0.624347826 0.551383399 0.434491634 kegg kegg NA NA no no no no no no Proteasome Estrogen signaling pathway 0 0.5 0 kegg kegg NA NA no no no no no no Protein export Estrogen signaling pathway 0 0.485177866 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Estrogen signaling pathway 0.455652174 0.651185771 0 kegg kegg NA NA no no no no no no Purine metabolism Estrogen signaling pathway 0 0.419960474 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Estrogen signaling pathway 0 0.747035573 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Estrogen signaling pathway 0.624347826 0.630434783 0.45045045 kegg kegg NA NA no no no no no no Ras signaling pathway Estrogen signaling pathway 0 0.56027668 0 yes kegg kegg NA NA no up up no no no Renin-angiotensin system Estrogen signaling pathway 0 -0.508893281 0 kegg kegg NA NA no no no no no no Retinol metabolism Estrogen signaling pathway 0.597391304 0.736166008 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Estrogen signaling pathway 0 0.71541502 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Estrogen signaling pathway 0 -0.745059289 0 kegg kegg NA NA no no no no no no RNA degradation Estrogen signaling pathway 0 0.52173913 0 kegg kegg NA NA no no no no no no RNA polymerase Estrogen signaling pathway 0 0.721343874 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Estrogen signaling pathway 0 0.443675889 0 kegg kegg NA NA no no no no no no Serotonergic synapse Estrogen signaling pathway 0.526956522 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Estrogen signaling pathway 0 0 -0.46048906 kegg kegg NA NA no no no no no no Sphingolipid metabolism Estrogen signaling pathway -0.616521739 0 -0.558043758 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Estrogen signaling pathway 0 -0.621541502 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Estrogen signaling pathway 0 0 -0.542342342 kegg kegg NA NA no no no no no no Steroid biosynthesis Estrogen signaling pathway 0.559130435 0.842885375 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Estrogen signaling pathway 0.448695652 0.834980237 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Estrogen signaling pathway 0 0 -0.48030888 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Estrogen signaling pathway 0.631304348 0.796442688 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Estrogen signaling pathway 0 -0.501976285 0 kegg kegg NA NA no no no no no no Taste transduction Estrogen signaling pathway 0.706086957 0.830039526 0 kegg kegg NA NA no no up no no no Terpenoid backbone biosynthesis Estrogen signaling pathway 0.579130435 0.643280632 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Estrogen signaling pathway 0 0.476284585 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Estrogen signaling pathway -0.656521739 0 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Estrogen signaling pathway -0.568695652 0 0 kegg kegg NA NA no no no no no no Thermogenesis Estrogen signaling pathway 0 0.427865613 0 kegg kegg NA NA no no no no no no Thiamine metabolism Estrogen signaling pathway 0 0.451581028 0 kegg kegg NA NA no no no no no no TNF signaling pathway Estrogen signaling pathway -0.406956522 -0.781620553 -0.475675676 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Estrogen signaling pathway 0 -0.835968379 -0.42033462 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Estrogen signaling pathway 0 0.648221344 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Estrogen signaling pathway 0.565217391 0.856719368 0.402831403 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Estrogen signaling pathway 0 0.780632411 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Estrogen signaling pathway 0 0.835968379 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Estrogen signaling pathway 0 0.523715415 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Estrogen signaling pathway 0 0.428853755 0.459459459 kegg kegg NA NA no no no no no no VEGF signaling pathway Estrogen signaling pathway 0 -0.648221344 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Estrogen signaling pathway 0 0.575098814 0 kegg kegg NA NA no no no no no no 12-ketoDCA+blood Ethanolamine+blood 0 0.490684079 0 serum_bileacids serum_aminoacids 0.517 0.122 no no no up no no 13-HODE+blood Ethanolamine+blood 0 0.5 0 serum_ARA serum_aminoacids 0.32 0.122 no no no up no no 14:0/20:4-PC+blood Ethanolamine+blood 0 0 -0.424273504 serum_phospholipids serum_aminoacids 0.486 0.122 no no no up no no 16:0/14:0-PC+blood Ethanolamine+blood 0.469172932 0 0 serum_phospholipids serum_aminoacids 0.0206 0.122 no up up up no no 16:0/16:1-PI+blood Ethanolamine+blood -0.488721805 0 0 serum_phospholipids serum_aminoacids 0.262 0.122 no no no up no no 16:0/18:0-PS+blood Ethanolamine+blood 0 -0.571078431 0 serum_phospholipids serum_aminoacids 0.377 0.122 no no no up no no 16:0/18:1-PC+blood Ethanolamine+blood 0.643609023 0 0 serum_phospholipids serum_aminoacids 6.15E-07 0.122 up up up up no no 16:0/18:2-PC+blood Ethanolamine+blood 0.496240602 0 0 serum_phospholipids serum_aminoacids 3.24E-06 0.122 no up up up no no 16:0/20:4-PC+blood Ethanolamine+blood 0.6 0 0 serum_phospholipids serum_aminoacids 0.0262 0.122 no up no up no no 16:0/20:4-PI+blood Ethanolamine+blood -0.502255639 0 0 serum_phospholipids serum_aminoacids 0.558 0.122 no no no up no no 16:1/16:0-PC+blood Ethanolamine+blood 0.448120301 0 0 serum_phospholipids serum_aminoacids 0.0215 0.122 no up up up no no 18:0-LPA+blood Ethanolamine+blood 0.518796992 0 0 serum_phospholipids serum_aminoacids 0.0725 0.122 no dn no up no no 18:0/16:0-PC+blood Ethanolamine+blood 0.603007519 0 0 serum_phospholipids serum_aminoacids 9.64E-07 0.122 up up up up no no 18:0/18:0-PC+blood Ethanolamine+blood 0.458646617 0 0 serum_phospholipids serum_aminoacids 0.426 0.122 no no no up no no 18:0/18:0-PE+blood Ethanolamine+blood 0 -0.487745098 0 serum_phospholipids serum_aminoacids 0.00896 0.122 up up no up no no 18:0/18:0-PS+blood Ethanolamine+blood 0 -0.708333333 0 serum_phospholipids serum_aminoacids 0.00617 0.122 no up no up no no 18:0/18:1-PE+blood Ethanolamine+blood 0 -0.553921569 0 serum_phospholipids serum_aminoacids 0.00716 0.122 up up no up no no 18:0/18:1-PG+blood Ethanolamine+blood 0 -0.568627451 0 serum_phospholipids serum_aminoacids 0.000842 0.122 no up no up no no 18:0/18:2-PC+blood Ethanolamine+blood 0.479699248 0 0 serum_phospholipids serum_aminoacids 1.74E-06 0.122 no up up up no no 18:0/20:4-PC+blood Ethanolamine+blood 0.461654135 0 0 serum_phospholipids serum_aminoacids 0.454 0.122 no no no up no no 18:0/22:6-PE+blood Ethanolamine+blood 0 -0.524509804 0 serum_phospholipids serum_aminoacids 0.00022 0.122 up up no up no no 18:1/16:0-PC+blood Ethanolamine+blood 0.514285714 0 0 serum_phospholipids serum_aminoacids 2.43E-05 0.122 no up up up no no 18:2-LPA+blood Ethanolamine+blood 0 0.634803922 0 serum_phospholipids serum_aminoacids 0.00684 0.122 dn no up up no no 18:2-LPE+blood Ethanolamine+blood 0 0.487745098 0 serum_phospholipids serum_aminoacids 0.112 0.122 no no no up no no 18:3/18:2-PC+blood Ethanolamine+blood 0 0 -0.468717949 serum_phospholipids serum_aminoacids 0.0394 0.122 no no up up no no 20:1/20:4-PE+blood Ethanolamine+blood 0 -0.634803922 0 serum_phospholipids serum_aminoacids 0.0042 0.122 up up no up no no 20:3/16:0-PC+blood Ethanolamine+blood 0.612030075 0 0 serum_phospholipids serum_aminoacids 0.00405 0.122 no up up up no no 20:4-LPA+blood Ethanolamine+blood 0 0.519607843 0 serum_phospholipids serum_aminoacids 0.398 0.122 no no no up no no 8-HETE+blood Ethanolamine+blood 0 0.495098039 0 serum_ARA serum_aminoacids 0.741 0.122 no no no up no no 9-HODE+blood Ethanolamine+blood -0.490225564 0 0 serum_ARA serum_aminoacids 0.297 0.122 no no no up no no Adherens junction Ethanolamine+blood 0.610526316 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Adipocytokine signaling pathway Ethanolamine+blood 0 0.652941176 0 kegg serum_aminoacids NA 0.122 no no no up no no Alcoholism Ethanolamine+blood -0.592982456 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Alistipes Ethanolamine+blood 0.510192312 0 0 Genus serum_aminoacids 0.0114 0.122 no up no up no no Amphetamine addiction Ethanolamine+blood 0 -0.591176471 0 kegg serum_aminoacids NA 0.122 no no no up no no Anaerostipes Ethanolamine+blood 0 0 -0.451553466 butyrate-producing Genus serum_aminoacids 0.568 0.122 no no no up no no Apelin signaling pathway Ethanolamine+blood 0 -0.532352941 0 kegg serum_aminoacids NA 0.122 no no no up no no Apoptosis Ethanolamine+blood 0.550877193 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Arrhythmogenic right ventricular cardiomyopathy Ethanolamine+blood 0.549122807 -0.505882353 0 kegg serum_aminoacids NA 0.122 no up up up no no Axon guidance Ethanolamine+blood -0.535087719 0 0 kegg serum_aminoacids NA 0.122 no up up up no no B cell receptor signaling pathway Ethanolamine+blood 0 0.611764706 0.572307692 kegg serum_aminoacids NA 0.122 no no no up no no Bacterial invasion of epithelial cells Ethanolamine+blood 0.563157895 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Bladder cancer Ethanolamine+blood 0 0.514705882 0 kegg serum_aminoacids NA 0.122 no no no up no no Breast cancer Ethanolamine+blood 0 0 0.414615385 kegg serum_aminoacids NA 0.122 no no no up no no C-type lectin receptor signaling pathway Ethanolamine+blood 0 0.644117647 0.506923077 kegg serum_aminoacids NA 0.122 no no no up no no cAMP signaling pathway Ethanolamine+blood 0 0.502941176 0 yes kegg serum_aminoacids NA 0.122 no up up up no no CDCA+blood Ethanolamine+blood 0 -0.522058824 0 serum_bileacids serum_aminoacids 0.506 0.122 no no no up no no Cell cycle Ethanolamine+blood 0 -0.538235294 0 kegg serum_aminoacids NA 0.122 no no no up no no Chagas disease Ethanolamine+blood 0 0.594117647 0 kegg serum_aminoacids NA 0.122 no no no up no no Chemokine signaling pathway Ethanolamine+blood 0 0.511764706 0 kegg serum_aminoacids NA 0.122 no no no up no no Choline+blood Ethanolamine+blood 0 0.485294118 0.532991453 serum_choline serum_aminoacids 0.0395 0.122 no up no up no no Chronic myeloid leukemia Ethanolamine+blood 0 0.623529412 0.573846154 kegg serum_aminoacids NA 0.122 no no no up no no Clostridium Ethanolamine+blood 0 -0.490157248 0 Genus serum_aminoacids 0.925 0.122 no no no up no no Creatinine+blood Ethanolamine+blood 0.460150376 0 0 serum_choline serum_aminoacids 0.437 0.122 no no no up no no Cytosolic DNA-sensing pathway Ethanolamine+blood 0 0.564705882 0 kegg serum_aminoacids NA 0.122 no no no up no no d18:0-18:3-SM+blood Ethanolamine+blood 0 0 -0.406495726 serum_phospholipids serum_aminoacids 0.0879 0.122 no dn no up no no d18:1-14:0-SM+blood Ethanolamine+blood 0 -0.632352941 0 serum_phospholipids serum_aminoacids 0.94 0.122 no no no up no no d18:1-14:1-SM+blood Ethanolamine+blood -0.464661654 -0.585784314 -0.445470085 serum_phospholipids serum_aminoacids 0.0952 0.122 no dn no up no no Dilated cardiomyopathy Ethanolamine+blood 0.492982456 0 0 kegg serum_aminoacids NA 0.122 no up up up no no DL-methionine sulfoxide+blood Ethanolamine+blood 0 0 0.42974359 serum_aminoacids serum_aminoacids 0.302 0.122 no no no up no no Epithelial cell signaling in Helicobacter pylori infection Ethanolamine+blood 0 0.644117647 0 kegg serum_aminoacids NA 0.122 no no no up no no Estrogen signaling pathway Ethanolamine+blood 0 -0.664705882 -0.436923077 kegg serum_aminoacids NA 0.122 no no no up no no Fluid shear stress and atherosclerosis Ethanolamine+blood 0.598245614 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Focal adhesion Ethanolamine+blood 0.457894737 -0.520588235 0 kegg serum_aminoacids NA 0.122 no up up up no no Gastric acid secretion Ethanolamine+blood 0.501754386 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Glycolysis / Gluconeogenesis Ethanolamine+blood 0 0 -0.455384615 kegg serum_aminoacids NA 0.122 no no no up no no HDCA+stool Ethanolamine+blood 0.593406593 0 0 stool_bileacids serum_aminoacids 0.176 0.122 no no no up no no Hematopoietic cell lineage Ethanolamine+blood 0 0 -0.513076923 kegg serum_aminoacids NA 0.122 no no no up no no Hepatitis B Ethanolamine+blood 0 0.564705882 0.493076923 kegg serum_aminoacids NA 0.122 no no no up no no Hepatocellular carcinoma Ethanolamine+blood 0.614035088 -0.508823529 0 kegg serum_aminoacids NA 0.122 no no no up no no HIF-1 signaling pathway Ethanolamine+blood 0 -0.502941176 0 kegg serum_aminoacids NA 0.122 no no no up no no Hippo signaling pathway Ethanolamine+blood 0.577192982 -0.585294118 0 kegg serum_aminoacids NA 0.122 no no no up no no Hypertrophic cardiomyopathy Ethanolamine+blood 0.524561404 0 0 kegg serum_aminoacids NA 0.122 no up up up no no Inflammatory mediator regulation of TRP channels Ethanolamine+blood 0 -0.511764706 0 kegg serum_aminoacids NA 0.122 no no no up no no Influenza A Ethanolamine+blood 0.626315789 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Insulin resistance Ethanolamine+blood 0 0.661764706 0.539230769 kegg serum_aminoacids NA 0.122 no no no up no no Insulin signaling pathway Ethanolamine+blood 0 -0.567647059 0 kegg serum_aminoacids NA 0.122 no no no up no no Leukocyte transendothelial migration Ethanolamine+blood 0.464912281 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Lipid and atherosclerosis Ethanolamine+blood 0 0.564705882 0 kegg serum_aminoacids NA 0.122 no no no up no no Long-term potentiation Ethanolamine+blood 0 -0.558823529 0 kegg serum_aminoacids NA 0.122 no no up up no no mRNA surveillance pathway Ethanolamine+blood 0 -0.502941176 0 kegg serum_aminoacids NA 0.122 no no no up no no Neurotrophin signaling pathway Ethanolamine+blood 0 0.638235294 0.559230769 kegg serum_aminoacids NA 0.122 no no no up no no NF-kappa B signaling pathway Ethanolamine+blood 0 0.605882353 0.437692308 kegg serum_aminoacids NA 0.122 no no no up no no NOD-like receptor signaling pathway Ethanolamine+blood 0 0.555882353 0 kegg serum_aminoacids NA 0.122 no no no up no no Odoribacter Ethanolamine+blood 0 0 0.406360337 butyrate-producing Genus serum_aminoacids 0.798 0.122 no no no up no no Oocyte meiosis Ethanolamine+blood 0 -0.641176471 0 kegg serum_aminoacids NA 0.122 no no no up no no Osteoclast differentiation Ethanolamine+blood 0 0.523529412 0 kegg serum_aminoacids NA 0.122 no no no up no no Oxytocin signaling pathway Ethanolamine+blood 0.480701754 0 0 kegg serum_aminoacids NA 0.122 no no no up no no p53 signaling pathway Ethanolamine+blood -0.540350877 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Parabacteroides Ethanolamine+blood 0.621052632 0 0.415113701 Genus serum_aminoacids 4.19E-05 0.122 no up up up no no Pathogenic Escherichia coli infection Ethanolamine+blood 0.514035088 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Pathways in cancer Ethanolamine+blood -0.5 0 0 kegg serum_aminoacids NA 0.122 no no no up no no PD-L1 expression and PD-1 checkpoint pathway in cancer Ethanolamine+blood 0 0.685294118 0.633846154 kegg serum_aminoacids NA 0.122 no no no up no no Platelet activation Ethanolamine+blood 0.478947368 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Platinum drug resistance Ethanolamine+blood -0.477192982 0 0 kegg serum_aminoacids NA 0.122 no no no up no no PPAR signaling pathway Ethanolamine+blood 0 0.588235294 0 kegg serum_aminoacids NA 0.122 no no no up no no Prevotella Ethanolamine+blood 0.460374502 0 0 Genus serum_aminoacids 0.367 0.122 no no no up no no Prevotella Ethanolamine+blood 0 0 0.41911497 acetate-producing Genus serum_aminoacids 0.287 0.122 no no no up no no Primary immunodeficiency Ethanolamine+blood 0 0 -0.466153846 kegg serum_aminoacids NA 0.122 no no no up no no Prolactin signaling pathway Ethanolamine+blood 0 0.544117647 0 kegg serum_aminoacids NA 0.122 no no no up no no Prostate cancer Ethanolamine+blood 0 0.614705882 0.580769231 kegg serum_aminoacids NA 0.122 no no no up no no Protein processing in endoplasmic reticulum Ethanolamine+blood 0 -0.620588235 0 kegg serum_aminoacids NA 0.122 no no no up no no Proteoglycans in cancer Ethanolamine+blood 0 -0.517647059 0 kegg serum_aminoacids NA 0.122 no no no up no no Pyramidobacter Ethanolamine+blood 0 0 0.48342045 Genus serum_aminoacids 0.45 0.122 no no no up no no Rap1 signaling pathway Ethanolamine+blood 0.540350877 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Ras signaling pathway Ethanolamine+blood 0 -0.626470588 0 yes kegg serum_aminoacids NA 0.122 no up up up no no Regulation of actin cytoskeleton Ethanolamine+blood 0 -0.555882353 0 kegg serum_aminoacids NA 0.122 no no no up no no Relaxin signaling pathway Ethanolamine+blood 0 0.561764706 0 kegg serum_aminoacids NA 0.122 no no no up no no Renin secretion Ethanolamine+blood 0 -0.532352941 0 kegg serum_aminoacids NA 0.122 no no no up no no RIG-I-like receptor signaling pathway Ethanolamine+blood 0 0.591176471 0 kegg serum_aminoacids NA 0.122 no no no up no no Small cell lung cancer Ethanolamine+blood 0 0.623529412 0.445384615 kegg serum_aminoacids NA 0.122 no no up up no no Spinocerebellar ataxia Ethanolamine+blood -0.477192982 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Spliceosome Ethanolamine+blood -0.487719298 0 0 kegg serum_aminoacids NA 0.122 no no no up no no T cell receptor signaling pathway Ethanolamine+blood 0 0.561764706 0 kegg serum_aminoacids NA 0.122 no no no up no no TCA+stool Ethanolamine+blood 0 0 -0.503759398 stool_bileacids serum_aminoacids 0.458 0.122 no no no up no no Th17 cell differentiation Ethanolamine+blood 0 0.502941176 0 kegg serum_aminoacids NA 0.122 no no no up no no Thyroid hormone signaling pathway Ethanolamine+blood 0.557894737 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Tight junction Ethanolamine+blood 0.489473684 0 0 kegg serum_aminoacids NA 0.122 no no no up no no TNF signaling pathway Ethanolamine+blood 0 0.667647059 0.51 kegg serum_aminoacids NA 0.122 no no no up no no Toll-like receptor signaling pathway Ethanolamine+blood 0 0.608823529 0 yes kegg serum_aminoacids NA 0.122 no no no up no no Transcriptional misregulation in cancer Ethanolamine+blood -0.596491228 0.573529412 0 kegg serum_aminoacids NA 0.122 no no no up no no Vibrio cholerae infection Ethanolamine+blood 0.60877193 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Viral myocarditis Ethanolamine+blood 0.461403509 0 0 kegg serum_aminoacids NA 0.122 no no no up no no Wnt signaling pathway Ethanolamine+blood 0 -0.552941176 0 kegg serum_aminoacids NA 0.122 no no no up no no "Alanine, aspartate and glutamate metabolism" Ether lipid metabolism -0.5 -0.540513834 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Ether lipid metabolism 0 0.462450593 0.432175032 kegg kegg NA NA no no no no no no Arginine and proline metabolism Ether lipid metabolism -0.476521739 -0.510869565 -0.462548263 kegg kegg NA NA no up no no no no Arginine biosynthesis Ether lipid metabolism -0.530434783 -0.601778656 -0.468725869 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Ether lipid metabolism 0 0.459486166 0.614929215 kegg kegg NA NA no no no no no no beta-Alanine metabolism Ether lipid metabolism -0.466956522 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Ether lipid metabolism 0 0.423913043 0.493436293 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Ether lipid metabolism -0.594782609 -0.595849802 0 kegg kegg NA NA no no no no no no Fatty acid degradation Ether lipid metabolism -0.636521739 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Ether lipid metabolism -0.410434783 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Ether lipid metabolism -0.420869565 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Ether lipid metabolism -0.456521739 0 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Ether lipid metabolism 0 0 0.544916345 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Ether lipid metabolism 0.439130435 0 0.711969112 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Ether lipid metabolism 0 0.541501976 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Ether lipid metabolism -0.571304348 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Ether lipid metabolism 0 0 0.551351351 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Ether lipid metabolism 0.580869565 0 0.407979408 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Ether lipid metabolism 0 0.651185771 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Ether lipid metabolism 0 0 0.635006435 kegg kegg NA NA no no no no no no Lysine degradation Ether lipid metabolism 0 0.422924901 0.577348777 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Ether lipid metabolism 0.645217391 0.416007905 0.585070785 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Ether lipid metabolism 0 0.587944664 0.411325611 kegg kegg NA NA no no no no no no Other glycan degradation Ether lipid metabolism 0 0 0.428828829 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Ether lipid metabolism 0.517391304 0.506916996 0.624967825 kegg kegg NA NA no no no no no no Oxidative phosphorylation Ether lipid metabolism 0.667826087 0.456521739 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Ether lipid metabolism 0 0.60770751 0.482368082 kegg kegg NA NA no no no no no no Pentose phosphate pathway Ether lipid metabolism 0 -0.682806324 -0.421879022 kegg kegg NA NA no no no no no no Purine metabolism Ether lipid metabolism 0 0.648221344 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Ether lipid metabolism -0.550434783 0.634387352 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Ether lipid metabolism 0 0.459486166 0.624453024 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Ether lipid metabolism -0.415652174 -0.438735178 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Ether lipid metabolism 0.42173913 0.421936759 0.631660232 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Ether lipid metabolism 0 0.453557312 0.573487773 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Ether lipid metabolism 0 0.567193676 0.581209781 kegg kegg NA NA no no no no no no Tyrosine metabolism Ether lipid metabolism 0 0.435770751 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Ether lipid metabolism 0 0.5 0.581209781 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Ether lipid metabolism 0 0.531620553 0.471042471 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Ether lipid metabolism 0 0.497035573 0 kegg kegg NA NA no no no no no no Eggerthella Faecalibacterium -0.54461403 0 0 butyrate-producing Genus Genus 0.912 0.0039 no no no no dn dn Roseburia Faecalibacterium 0 0.726977954 0 butyrate-producing butyrate-producing Genus Genus 0.495 0.0039 no no no no dn dn 2-Oxocarboxylic acid metabolism Fanconi anemia pathway 0 0.541501976 0.435778636 kegg kegg NA NA no no no no no no ABC transporters Fanconi anemia pathway 0.572173913 0.583003953 0.413899614 kegg kegg NA NA no up up no no no Amino sugar and nucleotide sugar metabolism Fanconi anemia pathway 0 0.681818182 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Fanconi anemia pathway 0.719130435 0.858695652 0.725611326 kegg kegg NA NA no no no no no no Antifolate resistance Fanconi anemia pathway 0.496521739 0.671936759 0.432689833 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Fanconi anemia pathway 0 0 -0.410553411 kegg kegg NA NA no no no no no no Arginine biosynthesis Fanconi anemia pathway 0 0 -0.461518662 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Fanconi anemia pathway 0.410434783 0 0.568082368 kegg kegg NA NA no no no no no no Basal transcription factors Fanconi anemia pathway 0.67826087 0.77173913 0.856370656 kegg kegg NA NA no no no no no no Base excision repair Fanconi anemia pathway 0.852173913 0.860671937 0.841698842 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Fanconi anemia pathway 0 -0.52173913 -0.576319176 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Fanconi anemia pathway 0 0.641304348 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Fanconi anemia pathway 0.615652174 0 0.401287001 kegg kegg NA NA no no no no no no Butanoate metabolism Fanconi anemia pathway 0.517391304 0.518774704 0.58970399 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Fanconi anemia pathway 0.589565217 0.488142292 0.674646075 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Fanconi anemia pathway 0.725217391 0.418972332 0.673101673 kegg kegg NA NA no no no no no no DNA replication Fanconi anemia pathway 0.916521739 0.735177866 0.863063063 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Fanconi anemia pathway 0 0.459486166 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Fanconi anemia pathway 0.407826087 0 0.434749035 kegg kegg NA NA no no no no no no Ether lipid metabolism Fanconi anemia pathway 0 0.537549407 0.625482625 kegg kegg NA NA no no no no no no Folate biosynthesis Fanconi anemia pathway 0.48 0 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Fanconi anemia pathway 0 0.503952569 0.508622909 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Fanconi anemia pathway 0 0.604743083 0.695238095 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Fanconi anemia pathway 0 0.493083004 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Fanconi anemia pathway -0.508695652 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Fanconi anemia pathway 0 0.42687747 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Fanconi anemia pathway -0.700869565 -0.425889328 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Fanconi anemia pathway 0 0.710474308 0.503474903 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Fanconi anemia pathway 0.692173913 0.712450593 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Fanconi anemia pathway 0 0 -0.465122265 kegg kegg NA NA no no no no no no Homologous recombination Fanconi anemia pathway 0.930434783 0.902173913 0.913770914 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Fanconi anemia pathway 0.470434783 0.648221344 0.648906049 kegg kegg NA NA no no no no no no Lysine degradation Fanconi anemia pathway 0.505217391 0.742094862 0.670527671 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Fanconi anemia pathway 0 0.475296443 0.565250965 kegg kegg NA NA no no no no no no Mismatch repair Fanconi anemia pathway 0.813913043 0.679841897 0.72020592 kegg kegg NA NA no no no no no no mRNA surveillance pathway Fanconi anemia pathway 0 0.453557312 0.596911197 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Fanconi anemia pathway 0.58173913 0.467391304 0.447104247 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Fanconi anemia pathway 0.640869565 0.523715415 0.743114543 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Fanconi anemia pathway 0 0 -0.48030888 kegg kegg NA NA no no no no no no Nitrogen metabolism Fanconi anemia pathway 0 0 -0.525611326 kegg kegg NA NA no no no no no no Non-homologous end-joining Fanconi anemia pathway 0.491304348 0 0.405920206 kegg kegg NA NA no no no no no no Nucleotide excision repair Fanconi anemia pathway 0.926956522 0.803359684 0.868468468 kegg kegg NA NA no no no no no no One carbon pool by folate Fanconi anemia pathway 0.867826087 0.782608696 0.823938224 kegg kegg NA NA no no no no no no Other glycan degradation Fanconi anemia pathway 0 0.429841897 0.475933076 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Fanconi anemia pathway 0.584347826 0.769762846 0.798455598 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Fanconi anemia pathway 0.513043478 0.529644269 0.616473616 kegg kegg NA NA no no no no no no Pentose phosphate pathway Fanconi anemia pathway -0.48 -0.668972332 -0.563449163 kegg kegg NA NA no no no no no no Phenylalanine metabolism Fanconi anemia pathway 0 0.428853755 0 kegg kegg NA NA no no no no no no Platinum drug resistance Fanconi anemia pathway 0.669565217 0.750988142 0.707593308 kegg kegg NA NA no no no no no no PPAR signaling pathway Fanconi anemia pathway 0 -0.428853755 -0.654311454 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Fanconi anemia pathway 0.736521739 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Fanconi anemia pathway 0.685217391 0 0.612612613 kegg kegg NA NA no no no no no no Protein export Fanconi anemia pathway 0.500869565 0 0.456628057 kegg kegg NA NA no no no no no no Purine metabolism Fanconi anemia pathway 0 0.506916996 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Fanconi anemia pathway 0.428695652 0.56916996 0.401801802 kegg kegg NA NA no no no no no no Pyruvate metabolism Fanconi anemia pathway 0.769565217 0.428853755 0.520720721 kegg kegg NA NA no no no no no no Retinol metabolism Fanconi anemia pathway 0.522608696 0.669960474 0.668983269 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Fanconi anemia pathway 0.804347826 0.903162055 0.914285714 kegg kegg NA NA no no no no no no RNA degradation Fanconi anemia pathway 0 0.432806324 0.680823681 kegg kegg NA NA no no no no no no RNA polymerase Fanconi anemia pathway 0.636521739 0.780632411 0.716859717 kegg kegg NA NA no no no no no no RNA transport Fanconi anemia pathway 0.648695652 0 0.403088803 kegg kegg NA NA no no no no no no Selenocompound metabolism Fanconi anemia pathway 0.62173913 0.89229249 0.877477477 kegg kegg NA NA no no no no no no Sphingolipid metabolism Fanconi anemia pathway -0.722608696 0 0 kegg kegg NA NA no no no no no no Spliceosome Fanconi anemia pathway 0.753913043 0.776679842 0.785842986 kegg kegg NA NA no no no no no no Steroid biosynthesis Fanconi anemia pathway 0.431304348 0.504940711 0.574517375 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Fanconi anemia pathway 0 0.492094862 0.524324324 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Fanconi anemia pathway 0.849565217 0.765810277 0.781724582 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Fanconi anemia pathway 0.649565217 0.674901186 0.724324324 kegg kegg NA NA no no no no no no Thiamine metabolism Fanconi anemia pathway 0.554782609 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Fanconi anemia pathway 0.513043478 0 0.522265122 kegg kegg NA NA no up no no no no Tyrosine metabolism Fanconi anemia pathway 0.439130435 0.536561265 0.4002574 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Fanconi anemia pathway 0.686956522 0.738142292 0.730501931 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Fanconi anemia pathway 0.736521739 0.645256917 0.68030888 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Fanconi anemia pathway 0.502608696 0.513833992 0.727155727 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Fat digestion and absorption 0 -0.544466403 0 yes kegg kegg NA NA no no no no up up Adrenergic signaling in cardiomyocytes Fat digestion and absorption -0.52173913 -0.753952569 -0.662548263 yes kegg kegg NA NA no no up no up up AGE-RAGE signaling pathway in diabetic complications Fat digestion and absorption 0 0.683794466 0 yes kegg kegg NA NA no no no no up up "Alanine, aspartate and glutamate metabolism" Fat digestion and absorption 0.72173913 0.709486166 0 yes kegg kegg NA NA no no no no up up Aldosterone synthesis and secretion Fat digestion and absorption -0.604347826 -0.682806324 -0.656628057 yes kegg kegg NA NA no up up no up up alpha-Linolenic acid metabolism Fat digestion and absorption 0.564347826 0.632411067 0.578378378 yes kegg kegg NA NA no no no no up up Amino sugar and nucleotide sugar metabolism Fat digestion and absorption 0.506086957 0 0.47027027 yes kegg kegg NA NA no no no no up up AMPK signaling pathway Fat digestion and absorption 0 -0.494071146 -0.478507079 yes kegg kegg NA NA no no no no up up Apelin signaling pathway Fat digestion and absorption 0 -0.574110672 0 yes kegg kegg NA NA no no no no up up Apoptosis Fat digestion and absorption 0.48 0.497035573 0.483140283 yes kegg kegg NA NA no no no no up up Arginine and proline metabolism Fat digestion and absorption 0.85826087 0.640316206 0.535649936 yes kegg kegg NA NA no up no no up up Arginine biosynthesis Fat digestion and absorption 0.784347826 0.735177866 0 yes kegg kegg NA NA no no no no up up Axon guidance Fat digestion and absorption -0.508695652 0 0 yes kegg kegg NA NA no up up no up up Basal transcription factors Fat digestion and absorption 0 -0.508893281 0 yes kegg kegg NA NA no no no no up up Biosynthesis of amino acids Fat digestion and absorption 0.617391304 0.778656126 0.617503218 yes kegg kegg NA NA no no no no up up Calcium signaling pathway Fat digestion and absorption -0.688695652 -0.563241107 -0.55006435 yes kegg kegg NA NA no up up no up up cAMP signaling pathway Fat digestion and absorption -0.408695652 0 0 yes yes kegg kegg NA NA no up up no up up Carbon metabolism Fat digestion and absorption 0.420869565 0.457509881 0.708622909 yes kegg kegg NA NA no no no no up up Cardiac muscle contraction Fat digestion and absorption -0.503478261 -0.626482213 0 yes kegg kegg NA NA no no up no up up Cell cycle Fat digestion and absorption 0 -0.618577075 -0.542857143 yes kegg kegg NA NA no no no no up up cGMP-PKG signaling pathway Fat digestion and absorption 0 0.774703557 0.538223938 yes kegg kegg NA NA no no no no up up Chemokine signaling pathway Fat digestion and absorption 0 0.608695652 0 yes kegg kegg NA NA no no no no up up Circadian entrainment Fat digestion and absorption 0 0 -0.447876448 yes kegg kegg NA NA no up up no up up Circadian rhythm Fat digestion and absorption -0.520869565 -0.663043478 -0.411583012 yes kegg kegg NA NA no no no no up up Collecting duct acid secretion Fat digestion and absorption 0 0.628458498 0 yes kegg kegg NA NA no no no no up up Complement and coagulation cascades Fat digestion and absorption 0.655652174 0.839920949 0 yes kegg kegg NA NA no no no no up up Cortisol synthesis and secretion Fat digestion and absorption -0.436521739 -0.43972332 -0.537966538 yes kegg kegg NA NA no no up no up up Cushing syndrome Fat digestion and absorption -0.587826087 -0.590909091 -0.63963964 yes kegg kegg NA NA no no up no up up Cytokine-cytokine receptor interaction Fat digestion and absorption 0 0.627470356 0 yes kegg kegg NA NA no no no no up up DNA replication Fat digestion and absorption 0 -0.51284585 0 yes kegg kegg NA NA no no no no up up Dopaminergic synapse Fat digestion and absorption -0.416521739 -0.433794466 -0.642471042 yes kegg kegg NA NA no up no no up up Drug metabolism - cytochrome P450 Fat digestion and absorption 0 0 0.407464607 yes kegg kegg NA NA no no no no up up Drug metabolism - other enzymes Fat digestion and absorption 0.408695652 0 0.497039897 yes kegg kegg NA NA no no no no up up ECM-receptor interaction Fat digestion and absorption 0 0 -0.492149292 yes kegg kegg NA NA no up up no up up EGFR tyrosine kinase inhibitor resistance Fat digestion and absorption -0.446956522 -0.576086957 0 yes kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Fat digestion and absorption -0.56173913 -0.613636364 -0.578635779 yes kegg kegg NA NA no no no no up up Endocrine resistance Fat digestion and absorption -0.453043478 0 -0.564221364 yes kegg kegg NA NA no no no no up up Estrogen signaling pathway Fat digestion and absorption 0 0 -0.526640927 yes kegg kegg NA NA no no no no up up Ether lipid metabolism Fat digestion and absorption -0.60173913 -0.504940711 0 yes kegg kegg NA NA no no no no up up Fatty acid biosynthesis Fat digestion and absorption 0.78173913 0.787549407 0.418790219 yes kegg kegg NA NA no no no no up up Fatty acid degradation Fat digestion and absorption 0.764347826 0.652173913 0.543371943 yes kegg kegg NA NA no no no no up up Fatty acid metabolism Fat digestion and absorption 0.730434783 0.752964427 0.491119691 yes kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway Fat digestion and absorption 0 0.612648221 0.575032175 yes kegg kegg NA NA no no no no up up Fc gamma R-mediated phagocytosis Fat digestion and absorption 0.613913043 0.788537549 0.494465894 yes kegg kegg NA NA no no no no up up Folate biosynthesis Fat digestion and absorption 0 -0.587944664 0 yes kegg kegg NA NA no no no no up up Fructose and mannose metabolism Fat digestion and absorption 0.507826087 0 0.632689833 yes kegg kegg NA NA no no no no up up GABAergic synapse Fat digestion and absorption 0.610434783 0.630434783 0 yes kegg kegg NA NA no up up no up up Galactose metabolism Fat digestion and absorption 0.533043478 0.633399209 0.594079794 yes kegg kegg NA NA no no no no up up Glucagon signaling pathway Fat digestion and absorption -0.516521739 -0.685770751 -0.677477477 yes kegg kegg NA NA no no no no up up Glutathione metabolism Fat digestion and absorption 0 -0.420948617 0 yes kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Fat digestion and absorption 0.624347826 0 0.530759331 yes kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Fat digestion and absorption 0 -0.539525692 0 yes kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate Fat digestion and absorption -0.649565217 -0.644268775 -0.413127413 yes kegg kegg NA NA no no no no up up Glycosaminoglycan degradation Fat digestion and absorption 0 0.418972332 0.552638353 yes kegg kegg NA NA no no up no up up Glyoxylate and dicarboxylate metabolism Fat digestion and absorption 0.724347826 0.742094862 0.46048906 yes kegg kegg NA NA no no no no up up GnRH signaling pathway Fat digestion and absorption -0.482608696 -0.416007905 -0.616216216 yes kegg kegg NA NA no no no no up up Hedgehog signaling pathway Fat digestion and absorption -0.476521739 -0.469367589 0 yes kegg kegg NA NA no no no no up up HIF-1 signaling pathway Fat digestion and absorption 0 -0.422924901 0 yes kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Fat digestion and absorption 0 0.445652174 0.541827542 yes kegg kegg NA NA no no no no up up Histidine metabolism Fat digestion and absorption 0.502608696 0 0.462033462 yes kegg kegg NA NA no no no no up up IL-17 signaling pathway Fat digestion and absorption 0.495652174 0.793478261 0.615701416 yes kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels Fat digestion and absorption -0.613913043 -0.637351779 -0.718146718 yes kegg kegg NA NA no no no no up up Insulin secretion Fat digestion and absorption -0.549565217 -0.586956522 -0.525611326 yes yes kegg kegg NA NA no up up no up up Insulin signaling pathway Fat digestion and absorption 0 -0.565217391 0 yes kegg kegg NA NA no no no no up up Long-term depression Fat digestion and absorption 0 0 -0.411325611 yes kegg kegg NA NA no no no no up up Longevity regulating pathway Fat digestion and absorption 0 0 -0.442728443 yes kegg kegg NA NA no no no no up up Lysine degradation Fat digestion and absorption -0.415652174 -0.565217391 0 yes kegg kegg NA NA no no no no up up Lysosome Fat digestion and absorption 0.430434783 0.639328063 0.814414414 yes kegg kegg NA NA no no no no up up Mannose type O-glycan biosynthesis Fat digestion and absorption -0.59826087 -0.581027668 0 yes kegg kegg NA NA no no no no up up Melanogenesis Fat digestion and absorption -0.624347826 -0.670948617 -0.757014157 yes kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 Fat digestion and absorption 0 0 0.441956242 yes kegg kegg NA NA no no no no up up Mitophagy - animal Fat digestion and absorption -0.467826087 -0.453557312 0 yes kegg kegg NA NA no no no no up up mRNA surveillance pathway Fat digestion and absorption -0.609565217 -0.920948617 -0.462290862 yes kegg kegg NA NA no no no no up up mTOR signaling pathway Fat digestion and absorption 0 -0.586956522 0 yes kegg kegg NA NA no no no no up up N-Glycan biosynthesis Fat digestion and absorption -0.611304348 -0.730237154 -0.421106821 yes kegg kegg NA NA no no no no up up Neuroactive ligand-receptor interaction Fat digestion and absorption 0 0.695652174 0.677477477 yes kegg kegg NA NA up up up no up up Neutrophil extracellular trap formation Fat digestion and absorption 0.63826087 0.811264822 0.58996139 yes kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Fat digestion and absorption 0.797391304 0.753952569 0.701158301 yes kegg kegg NA NA no no no no up up Nitrogen metabolism Fat digestion and absorption 0.693043478 0.673913043 0 yes kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Fat digestion and absorption 0.756521739 0.483201581 0 yes kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease Fat digestion and absorption -0.509565217 -0.650197628 -0.430888031 yes kegg kegg NA NA no no no no up up Olfactory transduction Fat digestion and absorption 0.533043478 0.827075099 0.722522523 yes kegg kegg NA NA no no no no up up Oocyte meiosis Fat digestion and absorption -0.459130435 0 -0.502702703 yes kegg kegg NA NA no no no no up up Osteoclast differentiation Fat digestion and absorption 0.569565217 0.688735178 0.553153153 yes kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis Fat digestion and absorption -0.428695652 -0.471343874 0 yes kegg kegg NA NA no no no no up up Oxidative phosphorylation Fat digestion and absorption -0.486956522 -0.599802372 0 yes kegg kegg NA NA no no no no up up Pancreatic secretion Fat digestion and absorption -0.555652174 -0.526679842 -0.558558559 yes kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis Fat digestion and absorption 0.686956522 0.792490119 0.716602317 yes kegg kegg NA NA no no dn no up up "Parathyroid hormone synthesis, secretion and action" Fat digestion and absorption -0.460869565 -0.553359684 -0.550836551 yes kegg kegg NA NA no no no no up up Pentose and glucuronate interconversions Fat digestion and absorption 0 -0.605731225 0 yes kegg kegg NA NA no no no no up up Pentose phosphate pathway Fat digestion and absorption 0.546956522 0.79743083 0.715315315 yes kegg kegg NA NA no no no no up up Peroxisome Fat digestion and absorption 0.691304348 0.799407115 0.409009009 yes kegg kegg NA NA no no no no up up Phagosome Fat digestion and absorption 0 0.563241107 0.416216216 yes kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system Fat digestion and absorption -0.634782609 0 0 yes kegg kegg NA NA no no no no up up PI3K-Akt signaling pathway Fat digestion and absorption 0 -0.468379447 0 yes yes kegg kegg NA NA no up up no up up PPAR signaling pathway Fat digestion and absorption 0.589565217 0.571146245 0.466151866 yes kegg kegg NA NA no no no no up up Prolactin signaling pathway Fat digestion and absorption 0 0.511857708 0 yes kegg kegg NA NA no no no no up up Protein digestion and absorption Fat digestion and absorption 0.537391304 0.475296443 0.424453024 yes yes kegg kegg NA NA no up up no up up Protein export Fat digestion and absorption -0.634782609 -0.685770751 0 yes kegg kegg NA NA no no no no up up Protein processing in endoplasmic reticulum Fat digestion and absorption -0.50173913 -0.79743083 -0.531788932 yes kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation Fat digestion and absorption 0 -0.51284585 0 yes kegg kegg NA NA no no no no up up Pyrimidine metabolism Fat digestion and absorption 0.50173913 0 0 yes kegg kegg NA NA no no no no up up Pyruvate metabolism Fat digestion and absorption 0 -0.427865613 0 yes kegg kegg NA NA no no no no up up Ras signaling pathway Fat digestion and absorption -0.573043478 -0.552371542 0 yes yes kegg kegg NA NA no up up no up up Regulation of lipolysis in adipocytes Fat digestion and absorption 0 0 -0.515057915 yes kegg kegg NA NA no no no no up up Renin secretion Fat digestion and absorption 0 -0.51284585 -0.596396396 yes kegg kegg NA NA no no no no up up Renin-angiotensin system Fat digestion and absorption 0.477391304 0.643280632 0.591505792 yes kegg kegg NA NA no no no no up up Retinol metabolism Fat digestion and absorption 0.415652174 0 0 yes kegg kegg NA NA no no no no up up Retrograde endocannabinoid signaling Fat digestion and absorption 0 -0.492094862 0 yes kegg kegg NA NA no no up no up up Ribosome Fat digestion and absorption -0.597391304 -0.543478261 0 yes kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes Fat digestion and absorption -0.437391304 -0.546442688 0 yes kegg kegg NA NA no no no no up up RNA degradation Fat digestion and absorption -0.691304348 -0.867588933 0 yes kegg kegg NA NA no no no no up up RNA polymerase Fat digestion and absorption -0.44173913 -0.711462451 0 yes kegg kegg NA NA no no no no up up RNA transport Fat digestion and absorption 0 -0.523715415 0 yes kegg kegg NA NA no no no no up up Signaling pathways regulating pluripotency of stem cells Fat digestion and absorption -0.446956522 -0.442687747 0 yes kegg kegg NA NA no no no no up up Sphingolipid metabolism Fat digestion and absorption 0 0 0.594851995 yes kegg kegg NA NA no no no no up up Spliceosome Fat digestion and absorption 0 -0.423913043 0 yes kegg kegg NA NA no no no no up up Starch and sucrose metabolism Fat digestion and absorption 0.793913043 0.807312253 0.784298584 yes kegg kegg NA NA no no no no up up Synaptic vesicle cycle Fat digestion and absorption 0.469565217 0.876482213 0.762162162 yes kegg kegg NA NA no up up no up up TGF-beta signaling pathway Fat digestion and absorption -0.700869565 -0.565217391 0 yes kegg kegg NA NA no no no no up up Thermogenesis Fat digestion and absorption -0.592173913 -0.623517787 0 yes kegg kegg NA NA no no no no up up Thyroid hormone synthesis Fat digestion and absorption -0.527826087 -0.51284585 0 yes kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway Fat digestion and absorption 0 0.522727273 0 yes yes kegg kegg NA NA no no no no up up Ubiquitin mediated proteolysis Fat digestion and absorption -0.616521739 -0.54743083 0 yes kegg kegg NA NA no no no no up up Various types of N-glycan biosynthesis Fat digestion and absorption -0.450434783 -0.634387352 0 yes kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Fat digestion and absorption -0.58 0 -0.467953668 yes kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption Fat digestion and absorption -0.526956522 -0.513833992 -0.564993565 yes kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor Fat digestion and absorption 0 0.576086957 0 yes kegg kegg NA NA no no no no up up Wnt signaling pathway Fat digestion and absorption -0.733043478 -0.81027668 0 yes kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism Fatty acid biosynthesis 0 -0.472332016 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Fatty acid biosynthesis 0 -0.653162055 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Fatty acid biosynthesis 0 0.418972332 0 kegg kegg NA NA no no no no no no Galactose metabolism Fatty acid biosynthesis 0 0.710474308 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Fatty acid biosynthesis 0 -0.459486166 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Fatty acid biosynthesis 0 -0.817193676 -0.495752896 kegg kegg NA NA no no no no no no Pentose phosphate pathway Fatty acid biosynthesis 0 0.688735178 0.587902188 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Fatty acid degradation 0 0 0.522007722 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Fatty acid degradation 0 0 0.52020592 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Fatty acid degradation 0.783478261 0.831027668 0.536164736 kegg kegg NA NA no no no no no no Fatty acid elongation Fatty acid degradation 0.454782609 0 0.542857143 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Fatty acid degradation 0.534782609 0.490118577 0.541827542 kegg kegg NA NA no no no no no no Galactose metabolism Fatty acid degradation 0.569565217 0.712450593 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Fatty acid degradation 0.553043478 0 0.46023166 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Fatty acid degradation 0 -0.447628458 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Fatty acid degradation 0 0.503952569 0.44967825 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Fatty acid elongation 0.590434783 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Fatty acid elongation 0.699130435 0.683794466 0.52046332 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Fatty acid elongation 0.491304348 -0.443675889 0 kegg kegg NA NA no no no no no no Galactose metabolism Fatty acid elongation 0.633913043 0 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Fatty acid elongation 0.693043478 0.745059289 0.701158301 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Fatty acid elongation 0.640869565 0.48715415 0.443243243 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Fatty acid metabolism 0.688695652 0.750988142 0.532561133 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Fatty acid metabolism 0.579130435 0.707509881 0.56962677 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Fatty acid metabolism 0.597391304 0 0.454054054 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Fatty acid metabolism 0.513913043 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Fatty acid metabolism 0.639130435 0.652173913 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Fatty acid metabolism 0.72173913 0.741106719 0.436808237 kegg kegg NA NA no no no no no no beta-Alanine metabolism Fatty acid metabolism 0.647826087 0 0.527670528 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Fatty acid metabolism 0.57826087 0 0.556756757 kegg kegg NA NA no no no no no no Butanoate metabolism Fatty acid metabolism 0.477391304 0 0.459202059 kegg kegg NA NA no no no no no no Carbon metabolism Fatty acid metabolism 0.603478261 0 0.593050193 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Fatty acid metabolism 0 0 0.425225225 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Fatty acid metabolism 0.53826087 -0.43972332 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Fatty acid metabolism -0.724347826 -0.440711462 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Fatty acid metabolism 0.723478261 0.807312253 0.502702703 kegg kegg NA NA no no no no no no Fatty acid degradation Fatty acid metabolism 0.933913043 0.941699605 0.94002574 kegg kegg NA NA no no no no no no Fatty acid elongation Fatty acid metabolism 0.62 0 0.593307593 kegg kegg NA NA no no no no no no Folate biosynthesis Fatty acid metabolism 0 -0.598814229 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Fatty acid metabolism 0.595652174 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Fatty acid metabolism 0.694782609 0.65513834 0 kegg kegg NA NA no no no no no no Glutathione metabolism Fatty acid metabolism 0 -0.524703557 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Fatty acid metabolism 0.577391304 0 0.453539254 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Fatty acid metabolism 0 0.447628458 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Fatty acid metabolism -0.650434783 -0.694664032 -0.404890605 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Fatty acid metabolism -0.410434783 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Fatty acid metabolism 0.826956522 0.750988142 0.46975547 kegg kegg NA NA no no no no no no Histidine metabolism Fatty acid metabolism 0.586086957 0.42687747 0.524581725 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Fatty acid metabolism -0.59826087 -0.431818182 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Fatty acid metabolism 0 -0.561264822 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Fatty acid metabolism 0.68173913 0.708498024 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Fatty acid metabolism 0.509565217 0.62944664 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Fatty acid metabolism -0.72 -0.826086957 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Fatty acid metabolism 0.632173913 0.798418972 0.673101673 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Fatty acid metabolism 0 -0.436758893 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Fatty acid metabolism 0 0.609683794 0.420849421 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Fatty acid metabolism 0.502608696 0 0.609009009 kegg kegg NA NA no no no no no no Propanoate metabolism Fatty acid metabolism 0.423478261 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Fatty acid metabolism 0.71826087 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Fatty acid metabolism 0.609565217 0 0.425225225 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Fatty acid metabolism 0.642608696 0.806324111 0.426769627 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Fatty acid metabolism 0.414782609 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Fatty acid metabolism 0 0 0.416473616 kegg kegg NA NA no no no no no no Tryptophan metabolism Fatty acid metabolism 0.575652174 0 0.572715573 kegg kegg NA NA no up no no no no Ubiquinone and other terpenoid-quinone biosynthesis Fatty acid metabolism 0.465217391 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Fatty acid metabolism 0.466086957 0 0.532046332 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Fc epsilon RI signaling pathway -0.506956522 -0.659090909 0 kegg kegg NA NA no no no no no no Adherens junction Fc epsilon RI signaling pathway 0 -0.451581028 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Fc epsilon RI signaling pathway 0 -0.606719368 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Fc epsilon RI signaling pathway 0 0.761857708 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Fc epsilon RI signaling pathway 0 0.527667984 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Fc epsilon RI signaling pathway -0.620869565 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Fc epsilon RI signaling pathway -0.445217391 -0.548418972 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Fc epsilon RI signaling pathway 0 -0.472332016 0 kegg kegg NA NA no no no no no no Antifolate resistance Fc epsilon RI signaling pathway 0 -0.428853755 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Fc epsilon RI signaling pathway -0.414782609 -0.815217391 -0.61981982 kegg kegg NA NA no no no no no no Apoptosis Fc epsilon RI signaling pathway 0 0.909090909 0.59047619 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Fc epsilon RI signaling pathway -0.528695652 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Fc epsilon RI signaling pathway 0 0.778656126 0.416731017 kegg kegg NA NA no up no no no no Arginine biosynthesis Fc epsilon RI signaling pathway 0 0.754940711 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Fc epsilon RI signaling pathway 0 -0.423913043 0 kegg kegg NA NA no no no no no no Autophagy - animal Fc epsilon RI signaling pathway 0 0.77173913 0.513770914 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Fc epsilon RI signaling pathway 0.712173913 0.84486166 0.601544402 kegg kegg NA NA no no no no no no Basal transcription factors Fc epsilon RI signaling pathway 0 -0.583992095 0 kegg kegg NA NA no no no no no no Base excision repair Fc epsilon RI signaling pathway 0 -0.536561265 -0.459202059 kegg kegg NA NA no no no no no no beta-Alanine metabolism Fc epsilon RI signaling pathway -0.44173913 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Fc epsilon RI signaling pathway 0 0.71541502 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Fc epsilon RI signaling pathway -0.694782609 -0.750988142 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Fc epsilon RI signaling pathway -0.419130435 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Fc epsilon RI signaling pathway -0.620869565 -0.796442688 -0.60978121 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Fc epsilon RI signaling pathway 0.613913043 0.851778656 0.513513514 kegg kegg NA NA no no no no no no cAMP signaling pathway Fc epsilon RI signaling pathway 0 0.515810277 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Fc epsilon RI signaling pathway -0.500869565 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Fc epsilon RI signaling pathway 0 -0.653162055 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Fc epsilon RI signaling pathway 0 0.583003953 0 kegg kegg NA NA no no no no no no Cell cycle Fc epsilon RI signaling pathway 0 -0.744071146 0 kegg kegg NA NA no no no no no no Cellular senescence Fc epsilon RI signaling pathway 0 0.729249012 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Fc epsilon RI signaling pathway 0.546956522 0.809288538 0.564993565 kegg kegg NA NA no no no no no no Chemokine signaling pathway Fc epsilon RI signaling pathway 0.43826087 0.691699605 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Fc epsilon RI signaling pathway -0.57826087 -0.796442688 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Fc epsilon RI signaling pathway 0 0.723320158 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Fc epsilon RI signaling pathway -0.686956522 -0.82312253 -0.659202059 kegg kegg NA NA no no no no no no DNA replication Fc epsilon RI signaling pathway -0.46173913 -0.833992095 -0.466151866 kegg kegg NA NA no no no no no no Dorea Fc epsilon RI signaling pathway -0.466956522 0 0 Genus kegg 0.00362 NA up no dn no no no Drug metabolism - cytochrome P450 Fc epsilon RI signaling pathway -0.615652174 -0.835968379 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Fc epsilon RI signaling pathway -0.62 -0.768774704 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Fc epsilon RI signaling pathway -0.506956522 -0.526679842 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Fc epsilon RI signaling pathway 0 -0.68972332 -0.589446589 kegg kegg NA NA no no no no no no Endocytosis Fc epsilon RI signaling pathway 0 0.630434783 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Fc epsilon RI signaling pathway 0.730434783 0.5256917 0.435778636 kegg kegg NA NA no no no no no no Ether lipid metabolism Fc epsilon RI signaling pathway 0 -0.577075099 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Fc epsilon RI signaling pathway 0 -0.488142292 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Fc epsilon RI signaling pathway 0 0.826086957 0.418275418 kegg kegg NA NA no no no no no no Fatty acid degradation Fc epsilon RI signaling pathway 0 0.562252964 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Fc epsilon RI signaling pathway 0 0.517786561 0 kegg kegg NA NA no no no no no no Focal adhesion Fc epsilon RI signaling pathway 0 -0.481225296 0 kegg kegg NA NA no up up no no no Folate biosynthesis Fc epsilon RI signaling pathway 0 -0.441699605 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Fc epsilon RI signaling pathway 0 0.533596838 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Fc epsilon RI signaling pathway -0.450434783 0.458498024 0 kegg kegg NA NA no no no no no no Galactose metabolism Fc epsilon RI signaling pathway 0 0.650197628 0.424195624 kegg kegg NA NA no no no no no no Glutathione metabolism Fc epsilon RI signaling pathway -0.527826087 -0.792490119 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Fc epsilon RI signaling pathway -0.543478261 -0.603754941 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Fc epsilon RI signaling pathway -0.706086957 -0.592885375 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Fc epsilon RI signaling pathway 0.450434783 0.82312253 0.683140283 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Fc epsilon RI signaling pathway 0.426956522 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Fc epsilon RI signaling pathway 0 0.556324111 0.4996139 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Fc epsilon RI signaling pathway 0 -0.476284585 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Fc epsilon RI signaling pathway 0.631304348 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Fc epsilon RI signaling pathway 0 0.769762846 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Fc epsilon RI signaling pathway 0.504347826 -0.457509881 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Fc epsilon RI signaling pathway 0 -0.645256917 -0.468468468 kegg kegg NA NA no no no no no no Hippo signaling pathway Fc epsilon RI signaling pathway 0 -0.565217391 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Fc epsilon RI signaling pathway 0.43826087 0.649209486 0.72972973 kegg kegg NA NA no no no no no no Homologous recombination Fc epsilon RI signaling pathway 0 0 -0.468468468 kegg kegg NA NA no no no no no no IL-17 signaling pathway Fc epsilon RI signaling pathway 0.433043478 0.806324111 0.537194337 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Fc epsilon RI signaling pathway 0 0.664031621 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Fc epsilon RI signaling pathway -0.549565217 0 0 kegg kegg NA NA no no no no no no Lysosome Fc epsilon RI signaling pathway 0.486956522 0.651185771 0.684942085 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Fc epsilon RI signaling pathway 0.44173913 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Fc epsilon RI signaling pathway -0.59826087 -0.757905138 0 kegg kegg NA NA no no no no no no Mismatch repair Fc epsilon RI signaling pathway -0.556521739 -0.756916996 -0.528185328 kegg kegg NA NA no no no no no no Mitophagy - animal Fc epsilon RI signaling pathway 0 -0.564229249 -0.550579151 kegg kegg NA NA no no no no no no mRNA surveillance pathway Fc epsilon RI signaling pathway 0 -0.641304348 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Fc epsilon RI signaling pathway 0 -0.699604743 -0.546975547 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Fc epsilon RI signaling pathway -0.566086957 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Fc epsilon RI signaling pathway 0 -0.818181818 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Fc epsilon RI signaling pathway 0 0.672924901 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Fc epsilon RI signaling pathway 0 0.597826087 0.48983269 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Fc epsilon RI signaling pathway 0 0.735177866 0.420592021 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Fc epsilon RI signaling pathway 0.446956522 0.802371542 0.404375804 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Fc epsilon RI signaling pathway 0 0.898221344 0.58043758 kegg kegg NA NA no no no no no no Nitrogen metabolism Fc epsilon RI signaling pathway 0 0.705533597 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Fc epsilon RI signaling pathway 0 0.828063241 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Fc epsilon RI signaling pathway -0.556521739 -0.497035573 -0.506821107 kegg kegg NA NA no no no no no no Notch signaling pathway Fc epsilon RI signaling pathway 0.775652174 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Fc epsilon RI signaling pathway -0.469565217 -0.791501976 -0.541055341 kegg kegg NA NA no no no no no no One carbon pool by folate Fc epsilon RI signaling pathway -0.419130435 -0.755928854 0 kegg kegg NA NA no no no no no no Oocyte meiosis Fc epsilon RI signaling pathway 0 -0.674901186 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Fc epsilon RI signaling pathway 0 0.906126482 0.653024453 kegg kegg NA NA no no no no no no Oxidative phosphorylation Fc epsilon RI signaling pathway 0 -0.681818182 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Fc epsilon RI signaling pathway 0 0.751976285 0.405405405 kegg kegg NA NA no no dn no no no Paraprevotella Fc epsilon RI signaling pathway 0 -0.441395835 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Fc epsilon RI signaling pathway -0.670434783 -0.840909091 -0.446589447 kegg kegg NA NA no no no no no no Pentose phosphate pathway Fc epsilon RI signaling pathway 0 0.744071146 0.476190476 kegg kegg NA NA no no no no no no Peroxisome Fc epsilon RI signaling pathway 0 0.653162055 0 kegg kegg NA NA no no no no no no Phagosome Fc epsilon RI signaling pathway 0 0.641304348 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Fc epsilon RI signaling pathway -0.417391304 -0.646245059 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Fc epsilon RI signaling pathway 0.686956522 0.783596838 0.602059202 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Fc epsilon RI signaling pathway 0 0 -0.51969112 yes kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism Fc epsilon RI signaling pathway -0.573913043 -0.589920949 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Fc epsilon RI signaling pathway 0 0.800395257 0.408751609 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Fc epsilon RI signaling pathway -0.526086957 -0.415019763 0 kegg kegg NA NA no no no no no no Propanoate metabolism Fc epsilon RI signaling pathway -0.697391304 -0.780632411 -0.637323037 kegg kegg NA NA no no no no no no Proteasome Fc epsilon RI signaling pathway 0 -0.623517787 0 kegg kegg NA NA no no no no no no Protein export Fc epsilon RI signaling pathway 0 -0.782608696 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Fc epsilon RI signaling pathway -0.611304348 -0.880434783 -0.758558559 kegg kegg NA NA no no no no no no Purine metabolism Fc epsilon RI signaling pathway -0.433913043 -0.603754941 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Fc epsilon RI signaling pathway -0.447826087 -0.712450593 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Fc epsilon RI signaling pathway -0.636521739 -0.890316206 -0.686743887 kegg kegg NA NA no no no no no no Ras signaling pathway Fc epsilon RI signaling pathway 0 -0.608695652 0 yes kegg kegg NA NA no up up no no no Renin-angiotensin system Fc epsilon RI signaling pathway 0 0.75 0.555727156 kegg kegg NA NA no no no no no no Retinol metabolism Fc epsilon RI signaling pathway -0.537391304 -0.564229249 0 kegg kegg NA NA no no no no no no Ribosome Fc epsilon RI signaling pathway 0 -0.716403162 -0.641698842 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Fc epsilon RI signaling pathway 0 -0.682806324 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Fc epsilon RI signaling pathway 0 0.773715415 0 kegg kegg NA NA no no no no no no RNA degradation Fc epsilon RI signaling pathway 0 -0.780632411 0 kegg kegg NA NA no no no no no no RNA polymerase Fc epsilon RI signaling pathway 0 -0.81916996 -0.437065637 kegg kegg NA NA no no no no no no RNA transport Fc epsilon RI signaling pathway -0.525217391 -0.62055336 -0.665894466 kegg kegg NA NA no no no no no no Sarcina Fc epsilon RI signaling pathway 0 0.422326513 0 Genus kegg 0.0703 NA no no no no no no Signaling pathways regulating pluripotency of stem cells Fc epsilon RI signaling pathway 0.544347826 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Fc epsilon RI signaling pathway 0 0.485177866 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Fc epsilon RI signaling pathway 0 0 0.581724582 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Fc epsilon RI signaling pathway 0.657391304 0.669960474 0.517374517 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Fc epsilon RI signaling pathway 0 0.803359684 0.602059202 kegg kegg NA NA no no no no no no Steroid biosynthesis Fc epsilon RI signaling pathway 0 -0.605731225 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Fc epsilon RI signaling pathway -0.534782609 -0.554347826 0 kegg kegg NA NA no no no no no no Sulfur metabolism Fc epsilon RI signaling pathway -0.530434783 -0.503952569 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Fc epsilon RI signaling pathway -0.493043478 -0.697628458 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Fc epsilon RI signaling pathway 0 -0.425889328 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Fc epsilon RI signaling pathway 0 -0.698616601 0 kegg kegg NA NA no no no no no no Thiamine metabolism Fc epsilon RI signaling pathway -0.445217391 -0.765810277 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Fc epsilon RI signaling pathway 0.489565217 0.886363636 0.52998713 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Fc epsilon RI signaling pathway -0.543478261 -0.529644269 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Fc epsilon RI signaling pathway -0.592173913 -0.757905138 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Fc epsilon RI signaling pathway -0.528695652 -0.666996047 -0.424967825 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Fc epsilon RI signaling pathway 0 -0.678853755 -0.58996139 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Fc epsilon RI signaling pathway -0.612173913 -0.740118577 -0.40978121 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Fc epsilon RI signaling pathway 0 -0.650197628 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Fc epsilon RI signaling pathway 0 -0.604743083 -0.458429858 kegg kegg NA NA no no no no no no VEGF signaling pathway Fc epsilon RI signaling pathway 0.829565217 0.65513834 0.50965251 kegg kegg NA NA no no no no no no Wnt signaling pathway Fc epsilon RI signaling pathway 0 -0.745059289 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Fc gamma R-mediated phagocytosis 0 -0.501976285 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Fc gamma R-mediated phagocytosis -0.484347826 -0.71541502 -0.533590734 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Fc gamma R-mediated phagocytosis 0.513913043 0.636363636 0.730759331 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Fc gamma R-mediated phagocytosis 0.446086957 0.501976285 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Fc gamma R-mediated phagocytosis 0.405217391 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Fc gamma R-mediated phagocytosis 0 -0.460474308 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Fc gamma R-mediated phagocytosis -0.642608696 -0.60770751 0 kegg kegg NA NA no no no no no no Antifolate resistance Fc gamma R-mediated phagocytosis 0 -0.47826087 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Fc gamma R-mediated phagocytosis 0 0 0.513770914 kegg kegg NA NA no no no no no no Apelin signaling pathway Fc gamma R-mediated phagocytosis -0.487826087 -0.527667984 0 kegg kegg NA NA no no no no no no Apoptosis Fc gamma R-mediated phagocytosis 0.570434783 0.616600791 0.578120978 kegg kegg NA NA no no no no no no Arginine and proline metabolism Fc gamma R-mediated phagocytosis 0.584347826 0.673913043 0.513256113 kegg kegg NA NA no up no no no no Arginine biosynthesis Fc gamma R-mediated phagocytosis 0.613913043 0.677865613 0.763449163 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Fc gamma R-mediated phagocytosis 0 0.533596838 0 kegg kegg NA NA no no no no no no Basal transcription factors Fc gamma R-mediated phagocytosis 0 -0.577075099 -0.48005148 kegg kegg NA NA no no no no no no Base excision repair Fc gamma R-mediated phagocytosis 0 -0.508893281 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Fc gamma R-mediated phagocytosis 0.60173913 0.871541502 0.818275418 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Fc gamma R-mediated phagocytosis 0 -0.527667984 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Fc gamma R-mediated phagocytosis 0 0.568181818 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Fc gamma R-mediated phagocytosis -0.515652174 -0.596837945 -0.558558559 kegg kegg NA NA no up up no no no Carbon metabolism Fc gamma R-mediated phagocytosis 0.454782609 0.537549407 0.731788932 kegg kegg NA NA no no no no no no Cardiac muscle contraction Fc gamma R-mediated phagocytosis 0 -0.644268775 -0.483655084 kegg kegg NA NA no no up no no no Cell adhesion molecules Fc gamma R-mediated phagocytosis 0 0.640316206 0 kegg kegg NA NA no no no no no no Cell cycle Fc gamma R-mediated phagocytosis 0 -0.732213439 -0.6 kegg kegg NA NA no no no no no no Cellular senescence Fc gamma R-mediated phagocytosis 0 0.571146245 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Fc gamma R-mediated phagocytosis 0.531304348 0.89229249 0.506563707 kegg kegg NA NA no no no no no no Chemokine signaling pathway Fc gamma R-mediated phagocytosis 0 0.632411067 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Fc gamma R-mediated phagocytosis 0.57826087 0.852766798 0.712741313 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Fc gamma R-mediated phagocytosis 0 0.601778656 0 kegg kegg NA NA no no no no no no DNA replication Fc gamma R-mediated phagocytosis 0 -0.602766798 -0.433976834 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Fc gamma R-mediated phagocytosis 0 -0.510869565 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Fc gamma R-mediated phagocytosis -0.576521739 -0.495059289 0 kegg kegg NA NA no no no no no no Endocrine resistance Fc gamma R-mediated phagocytosis -0.569565217 -0.54743083 0 kegg kegg NA NA no no no no no no Endocytosis Fc gamma R-mediated phagocytosis 0.452173913 0.698616601 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Fc gamma R-mediated phagocytosis -0.546956522 -0.579051383 -0.514543115 kegg kegg NA NA no no no no no no Fanconi anemia pathway Fc gamma R-mediated phagocytosis 0 -0.529644269 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Fc gamma R-mediated phagocytosis 0.619130435 0.713438735 0.620849421 kegg kegg NA NA no no no no no no Fatty acid degradation Fc gamma R-mediated phagocytosis 0.672173913 0.610671937 0.481081081 kegg kegg NA NA no no no no no no Fatty acid elongation Fc gamma R-mediated phagocytosis 0.517391304 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Fc gamma R-mediated phagocytosis 0.72 0.706521739 0.578120978 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis 0 0.72826087 0 kegg kegg NA NA no no no no no no Folate biosynthesis Fc gamma R-mediated phagocytosis 0 -0.502964427 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Fc gamma R-mediated phagocytosis 0.413913043 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Fc gamma R-mediated phagocytosis 0.494782609 0.493083004 0 kegg kegg NA NA no no no no no no Glutathione metabolism Fc gamma R-mediated phagocytosis -0.477391304 -0.60770751 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Fc gamma R-mediated phagocytosis 0 0 -0.483912484 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Fc gamma R-mediated phagocytosis 0 0 -0.516344916 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Fc gamma R-mediated phagocytosis -0.471304348 -0.451581028 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Fc gamma R-mediated phagocytosis 0.450434783 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Fc gamma R-mediated phagocytosis 0 0 -0.403603604 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Fc gamma R-mediated phagocytosis -0.526956522 -0.491106719 -0.464607465 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Fc gamma R-mediated phagocytosis 0.408695652 0.563241107 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Fc gamma R-mediated phagocytosis 0 -0.471343874 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Fc gamma R-mediated phagocytosis 0 -0.5 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Fc gamma R-mediated phagocytosis 0.569565217 0.707509881 0.771428571 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Fc gamma R-mediated phagocytosis 0 -0.54743083 -0.664092664 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Fc gamma R-mediated phagocytosis -0.433913043 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Fc gamma R-mediated phagocytosis 0.456521739 0.486166008 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Fc gamma R-mediated phagocytosis 0.673043478 0.850790514 0.718404118 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Fc gamma R-mediated phagocytosis 0 0 -0.436550837 kegg kegg NA NA no no no no no no Longevity regulating pathway Fc gamma R-mediated phagocytosis -0.572173913 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Fc gamma R-mediated phagocytosis 0.484347826 0.423913043 0.414157014 kegg kegg NA NA no no no no no no Lysine degradation Fc gamma R-mediated phagocytosis -0.470434783 -0.611660079 -0.677992278 kegg kegg NA NA no no no no no no Lysosome Fc gamma R-mediated phagocytosis 0.577391304 0.833992095 0.657400257 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Fc gamma R-mediated phagocytosis -0.526086957 -0.572134387 -0.726126126 kegg kegg NA NA no no no no no no Mitophagy - animal Fc gamma R-mediated phagocytosis -0.810434783 -0.617588933 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Fc gamma R-mediated phagocytosis -0.546086957 -0.856719368 -0.779407979 kegg kegg NA NA no no no no no no mTOR signaling pathway Fc gamma R-mediated phagocytosis -0.591304348 -0.491106719 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Fc gamma R-mediated phagocytosis 0 -0.697628458 -0.462033462 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Fc gamma R-mediated phagocytosis 0.413913043 0.644268775 0 kegg kegg NA NA no no no no no no Necroptosis Fc gamma R-mediated phagocytosis -0.570434783 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Fc gamma R-mediated phagocytosis 0.762608696 0.92687747 0.836550837 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Fc gamma R-mediated phagocytosis 0.85826087 0.935770751 0.821364221 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Fc gamma R-mediated phagocytosis 0.728695652 0.763833992 0.692406692 kegg kegg NA NA no no no no no no Nitrogen metabolism Fc gamma R-mediated phagocytosis 0.471304348 0.610671937 0.612870013 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Fc gamma R-mediated phagocytosis 0.765217391 0.639328063 0.592277992 kegg kegg NA NA no no no no no no Notch signaling pathway Fc gamma R-mediated phagocytosis 0 0 -0.44993565 kegg kegg NA NA no no no no no no Nucleotide excision repair Fc gamma R-mediated phagocytosis 0 -0.549407115 0 kegg kegg NA NA no no no no no no Odoribacter Fc gamma R-mediated phagocytosis 0 0.421001786 0 butyrate-producing Genus kegg 0.798 NA no no no no no no One carbon pool by folate Fc gamma R-mediated phagocytosis 0 -0.559288538 -0.581981982 kegg kegg NA NA no no no no no no Osteoclast differentiation Fc gamma R-mediated phagocytosis 0.78 0.862648221 0.661776062 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Fc gamma R-mediated phagocytosis -0.42173913 -0.585968379 -0.586100386 kegg kegg NA NA no no no no no no Oxidative phosphorylation Fc gamma R-mediated phagocytosis 0 -0.612648221 0 kegg kegg NA NA no no no no no no p53 signaling pathway Fc gamma R-mediated phagocytosis 0 0 -0.43989704 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Fc gamma R-mediated phagocytosis 0.834782609 0.793478261 0.695495495 kegg kegg NA NA no no dn no no no Paraprevotella Fc gamma R-mediated phagocytosis 0 -0.461925874 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Fc gamma R-mediated phagocytosis 0 -0.577075099 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Fc gamma R-mediated phagocytosis 0.606086957 0.928853755 0.757528958 kegg kegg NA NA no no no no no no Peroxisome Fc gamma R-mediated phagocytosis 0.716521739 0.754940711 0.707850708 kegg kegg NA NA no no no no no no Phagosome Fc gamma R-mediated phagocytosis 0.46173913 0.778656126 0.525611326 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Fc gamma R-mediated phagocytosis 0 0 -0.584041184 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Fc gamma R-mediated phagocytosis -0.449565217 -0.454545455 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Fc gamma R-mediated phagocytosis 0 0.693675889 0.55032175 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Fc gamma R-mediated phagocytosis 0 0 0.543371943 kegg kegg NA NA no no no no no no Protein export Fc gamma R-mediated phagocytosis -0.546086957 -0.551383399 -0.578893179 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Fc gamma R-mediated phagocytosis -0.579130435 -0.818181818 0 kegg kegg NA NA no no no no no no Purine metabolism Fc gamma R-mediated phagocytosis -0.576521739 -0.578063241 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Fc gamma R-mediated phagocytosis 0 -0.470355731 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Fc gamma R-mediated phagocytosis 0 -0.473320158 0 kegg kegg NA NA no no no no no no Ras signaling pathway Fc gamma R-mediated phagocytosis 0 -0.418972332 -0.467696268 yes kegg kegg NA NA no up up no no no Renin-angiotensin system Fc gamma R-mediated phagocytosis 0.797391304 0.880434783 0.658172458 kegg kegg NA NA no no no no no no Retinol metabolism Fc gamma R-mediated phagocytosis 0.462608696 0 0 kegg kegg NA NA no no no no no no Ribosome Fc gamma R-mediated phagocytosis -0.804347826 -0.562252964 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Fc gamma R-mediated phagocytosis -0.424347826 -0.682806324 -0.572715573 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Fc gamma R-mediated phagocytosis 0 0.42687747 0 kegg kegg NA NA no no no no no no RNA degradation Fc gamma R-mediated phagocytosis -0.553043478 -0.805335968 -0.673873874 kegg kegg NA NA no no no no no no RNA polymerase Fc gamma R-mediated phagocytosis -0.54 -0.802371542 -0.532561133 kegg kegg NA NA no no no no no no RNA transport Fc gamma R-mediated phagocytosis 0 -0.418972332 0 kegg kegg NA NA no no no no no no Ruminococcus Fc gamma R-mediated phagocytosis -0.654782609 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Signaling pathways regulating pluripotency of stem cells Fc gamma R-mediated phagocytosis 0 -0.423913043 -0.475675676 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Fc gamma R-mediated phagocytosis 0 0.585968379 0 kegg kegg NA NA no no no no no no Spliceosome Fc gamma R-mediated phagocytosis 0 0 -0.48983269 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Fc gamma R-mediated phagocytosis 0.715652174 0.686758893 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Fc gamma R-mediated phagocytosis 0 0 -0.604118404 kegg kegg NA NA no no no no no no Tight junction Fc gamma R-mediated phagocytosis 0 0 0.422651223 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Fc gamma R-mediated phagocytosis 0 0.631422925 0 yes kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Fc gamma R-mediated phagocytosis -0.864347826 -0.732213439 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Fc gamma R-mediated phagocytosis 0 -0.545454545 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Fc gamma R-mediated phagocytosis -0.55826087 -0.424901186 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Fc gamma R-mediated phagocytosis 0 0.541501976 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Fc gamma R-mediated phagocytosis 0 -0.760869565 -0.663063063 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Ferroptosis 0 -0.57312253 -0.553153153 kegg kegg NA NA no no no no no no ABC transporters Ferroptosis -0.540869565 0 0 kegg kegg NA NA no up up no no no Alistipes Ferroptosis 0 -0.413572343 0 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism Ferroptosis 0 0 -0.431402831 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Ferroptosis -0.42 -0.500988142 -0.40952381 kegg kegg NA NA no no no no no no AMPK signaling pathway Ferroptosis 0 0 0.651222651 kegg kegg NA NA no no no no no no Antifolate resistance Ferroptosis 0 -0.431818182 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Ferroptosis 0.409565217 0.450592885 0.571171171 kegg kegg NA NA no no no no no no Arginine biosynthesis Ferroptosis 0 0 0.410810811 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Ferroptosis 0 0 -0.427799228 kegg kegg NA NA no no no no no no Autophagy - other Ferroptosis 0 0 -0.434749035 kegg kegg NA NA no no no no no no Base excision repair Ferroptosis -0.44 -0.467391304 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Ferroptosis 0 -0.522727273 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Ferroptosis 0 0 0.613127413 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Ferroptosis -0.486956522 -0.54743083 0 kegg kegg NA NA no no no no no no Butanoate metabolism Ferroptosis 0 -0.591897233 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Ferroptosis 0 0.59486166 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Ferroptosis 0 -0.418972332 0 kegg kegg NA NA no no no no no no Cell cycle Ferroptosis -0.474782609 -0.420948617 -0.533848134 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Ferroptosis -0.437391304 -0.577075099 -0.45997426 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Ferroptosis 0 -0.464426877 0 kegg kegg NA NA no no no no no no DNA replication Ferroptosis -0.52 -0.54743083 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Ferroptosis 0 0 -0.646846847 kegg kegg NA NA no no no no no no Fanconi anemia pathway Ferroptosis -0.545217391 0 -0.490862291 kegg kegg NA NA no no no no no no Fatty acid elongation Ferroptosis 0 -0.533596838 0 kegg kegg NA NA no no no no no no Folate biosynthesis Ferroptosis -0.448695652 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Ferroptosis 0.483478261 0 0.656113256 kegg kegg NA NA no no no no no no Glycerolipid metabolism Ferroptosis 0 0 -0.665379665 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Ferroptosis 0 0 -0.554440154 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Ferroptosis 0 0 0.635263835 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Ferroptosis 0 -0.511857708 -0.557271557 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Ferroptosis 0 0 -0.503732304 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Ferroptosis 0 -0.564229249 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Ferroptosis 0.439130435 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Ferroptosis -0.493913043 0 0 kegg kegg NA NA no no no no no no Homologous recombination Ferroptosis -0.531304348 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Ferroptosis -0.643478261 0 -0.61003861 kegg kegg NA NA no no no no no no Longevity regulating pathway Ferroptosis 0.427826087 0 0.657657658 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Ferroptosis -0.455652174 -0.52173913 0 kegg kegg NA NA no no no no no no Lysine degradation Ferroptosis 0 0 -0.564993565 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Ferroptosis 0 0 -0.540540541 kegg kegg NA NA no no no no no no MAPK signaling pathway Ferroptosis 0 0 -0.539253539 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Ferroptosis 0 -0.444664032 0 kegg kegg NA NA no no no no no no Mismatch repair Ferroptosis -0.47826087 -0.467391304 0 kegg kegg NA NA no no no no no no Mitophagy - animal Ferroptosis 0.651304348 0.420948617 0.756241956 kegg kegg NA NA no no no no no no mRNA surveillance pathway Ferroptosis 0 0 -0.411583012 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Ferroptosis 0 -0.513833992 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Ferroptosis -0.444347826 -0.448616601 -0.605405405 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Ferroptosis -0.55826087 0 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Ferroptosis 0 0.416007905 0.465894466 kegg kegg NA NA no no no no no no Non-homologous end-joining Ferroptosis -0.43826087 -0.567193676 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Ferroptosis -0.527826087 -0.52173913 0 kegg kegg NA NA no no no no no no Odoribacter Ferroptosis 0 -0.459139595 0 butyrate-producing Genus kegg 0.798 NA no no no no no no One carbon pool by folate Ferroptosis -0.437391304 -0.482213439 -0.496267696 kegg kegg NA NA no no no no no no Oocyte meiosis Ferroptosis 0 -0.556324111 -0.461003861 kegg kegg NA NA no no no no no no Other glycan degradation Ferroptosis 0 0 -0.696267696 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Ferroptosis 0 0 -0.601287001 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Ferroptosis 0 -0.527667984 -0.52972973 kegg kegg NA NA no no no no no no Phenylalanine metabolism Ferroptosis 0 -0.542490119 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Ferroptosis 0 -0.625494071 -0.595881596 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Ferroptosis 0 0.419960474 0 kegg kegg NA NA no up up no no no Platinum drug resistance Ferroptosis 0 0 -0.423166023 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Ferroptosis 0 0 0.688545689 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Ferroptosis -0.503478261 -0.531620553 0 kegg kegg NA NA no no no no no no Propanoate metabolism Ferroptosis 0 -0.425889328 0 kegg kegg NA NA no no no no no no Purine metabolism Ferroptosis 0 0 0.792020592 kegg kegg NA NA no no no no no no Pyrimidine metabolism Ferroptosis 0 -0.414031621 0 kegg kegg NA NA no no no no no no Ras signaling pathway Ferroptosis 0 -0.427865613 -0.451737452 yes kegg kegg NA NA no up up no no no Retinol metabolism Ferroptosis 0 -0.614624506 -0.457657658 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Ferroptosis 0 -0.441699605 -0.548519949 kegg kegg NA NA no no no no no no RNA degradation Ferroptosis 0 0 -0.580694981 kegg kegg NA NA no no no no no no Selenocompound metabolism Ferroptosis 0 0 -0.540797941 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Ferroptosis -0.423478261 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Ferroptosis 0 0 -0.57014157 kegg kegg NA NA no no no no no no Spliceosome Ferroptosis 0 0 -0.520720721 kegg kegg NA NA no no no no no no Steroid biosynthesis Ferroptosis 0 -0.510869565 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Ferroptosis 0 -0.415019763 0 kegg kegg NA NA no no no no no no Sulfur metabolism Ferroptosis 0 0 0.55984556 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Ferroptosis -0.409565217 -0.603754941 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Ferroptosis 0 -0.556324111 -0.437065637 kegg kegg NA NA no no no no no no Tryptophan metabolism Ferroptosis -0.412173913 -0.662055336 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Ferroptosis 0 -0.424901186 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Ferroptosis 0 -0.602766798 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Ferroptosis 0.520869565 0 0.738996139 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Ferroptosis -0.472173913 -0.580039526 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Ferroptosis 0 -0.583003953 -0.728442728 kegg kegg NA NA no no no no no no 16:0/18:2-PI+blood FGF basic 0 0 -0.562406015 serum_phospholipids serum_cytokines 0.269 0.65 no no no no no no 16:0/22:6-PC+blood FGF basic -0.672727273 0 0 serum_phospholipids serum_cytokines 4.53E-05 0.65 no up up no no no 16:1/16:1-PC+blood FGF basic 0 -0.564285714 0 serum_phospholipids serum_cytokines 0.0177 0.65 no no up no no no 18:0-LPC+blood FGF basic 0 0 -0.466165414 serum_phospholipids serum_cytokines 0.554 0.65 no no no no no no 18:1/18:1-PC+blood FGF basic 0 0.542857143 0 serum_phospholipids serum_cytokines 1.34E-05 0.65 no up up no no no 18:3n3+blood FGF basic 0 -0.628571429 0 serum_fattyacid serum_cytokines 0.291 0.65 no no no no no no 20:0+blood FGF basic 0.660606061 0 -0.717293233 yes serum_fattyacid serum_cytokines 0.000278 0.65 dn no up no no no 4-hydroxy-3-methoxymandelic acid+urine FGF basic 0 0.5 0 urine_cometabolism serum_cytokines 0.973 0.65 no no no no no no AA+blood FGF basic -0.696969697 0 0 serum_ARA serum_cytokines 0.212 0.65 no no no no no no Acute myeloid leukemia FGF basic 0 0.572932331 0 kegg serum_cytokines NA 0.65 no no no no no no Adipocytokine signaling pathway FGF basic 0 0 -0.406130268 kegg serum_cytokines NA 0.65 no no no no no no AGE-RAGE signaling pathway in diabetic complications FGF basic -0.593406593 0 0 kegg serum_cytokines NA 0.65 no no no no no no Aldosterone synthesis and secretion FGF basic 0 0 -0.402298851 kegg serum_cytokines NA 0.65 no up up no no no Allograft rejection FGF basic -0.78021978 0 0 kegg serum_cytokines NA 0.65 no no no no no no Alzheimer disease FGF basic 0.796703297 0 0 kegg serum_cytokines NA 0.65 no no no no no no Amoebiasis FGF basic 0 0.458646617 0 kegg serum_cytokines NA 0.65 no no no no no no Amyotrophic lateral sclerosis FGF basic 0.840659341 0 0 kegg serum_cytokines NA 0.65 no no no no no no Apoptosis FGF basic 0 0.518796992 0 kegg serum_cytokines NA 0.65 no no no no no no Arrhythmogenic right ventricular cardiomyopathy FGF basic 0 0 0.444444444 kegg serum_cytokines NA 0.65 no up up no no no Autoimmune thyroid disease FGF basic -0.78021978 0 0 kegg serum_cytokines NA 0.65 no no no no no no Axon guidance FGF basic 0 0.544360902 0 kegg serum_cytokines NA 0.65 no up up no no no B cell receptor signaling pathway FGF basic 0 0.455639098 0 kegg serum_cytokines NA 0.65 no no no no no no Bacterial invasion of epithelial cells FGF basic 0 0 0.48166393 kegg serum_cytokines NA 0.65 no no no no no no Bacteroides FGF basic -0.642857143 0 0 LPS-producing Genus serum_cytokines 0.000267 0.65 dn dn up no no no Bifidobacterium FGF basic 0 0 -0.450774061 acetate-producing Genus serum_cytokines 0.105 0.65 no dn no no no no Biosynthesis of amino acids FGF basic -0.648351648 0 0 kegg serum_cytokines NA 0.65 no no no no no no Biosynthesis of cofactors FGF basic 0 -0.523308271 0 kegg serum_cytokines NA 0.65 no no no no no no C-type lectin receptor signaling pathway FGF basic 0 0 -0.469622332 kegg serum_cytokines NA 0.65 no no no no no no Calcium signaling pathway FGF basic 0 0 -0.436781609 kegg serum_cytokines NA 0.65 no up up no no no cAMP signaling pathway FGF basic 0 0.478195489 -0.51833607 yes kegg serum_cytokines NA 0.65 no up up no no no Carbon metabolism FGF basic 0 0 0.452654625 kegg serum_cytokines NA 0.65 no no no no no no Cardiac muscle contraction FGF basic 0.835164835 0 0 kegg serum_cytokines NA 0.65 no no up no no no Cell adhesion molecules FGF basic -0.741758242 0 0 kegg serum_cytokines NA 0.65 no no no no no no Cellular senescence FGF basic -0.642857143 0 0 kegg serum_cytokines NA 0.65 no no no no no no Chagas disease FGF basic 0 0.481203008 0 kegg serum_cytokines NA 0.65 no no no no no no Chemical carcinogenesis - receptor activation FGF basic 0 0 -0.484400657 kegg serum_cytokines NA 0.65 no no no no no no Chronic myeloid leukemia FGF basic 0 0.606015038 -0.497536946 kegg serum_cytokines NA 0.65 no no no no no no Cocaine addiction FGF basic 0 0 -0.408866995 kegg serum_cytokines NA 0.65 no no no no no no Cortisol synthesis and secretion FGF basic 0 0 -0.417624521 kegg serum_cytokines NA 0.65 no no up no no no Cytosolic DNA-sensing pathway FGF basic 0 0.502255639 0 kegg serum_cytokines NA 0.65 no no no no no no d18:1-22:0-SM+blood FGF basic 0.721212121 0 0 serum_phospholipids serum_cytokines 0.522 0.65 no no no no no no Diabetic cardiomyopathy FGF basic 0.851648352 0 0 kegg serum_cytokines NA 0.65 no no no no no no Endocytosis FGF basic -0.708791209 0 0 kegg serum_cytokines NA 0.65 no no no no no no Estrogen signaling pathway FGF basic 0 -0.448120301 0 kegg serum_cytokines NA 0.65 no no no no no no Fc epsilon RI signaling pathway FGF basic 0 0.45112782 0 kegg serum_cytokines NA 0.65 no no no no no no Focal adhesion FGF basic 0 0 0.578544061 kegg serum_cytokines NA 0.65 no up up no no no GCA+blood FGF basic 0 0 0.472180451 yes serum_bileacids serum_cytokines 0.16 0.65 no no no no no no Glycolysis / Gluconeogenesis FGF basic 0 0 0.48166393 kegg serum_cytokines NA 0.65 no no no no no no Graft-versus-host disease FGF basic -0.758241758 0 0 kegg serum_cytokines NA 0.65 no no no no no no "Growth hormone synthesis, secretion and action" FGF basic 0 0 -0.47454844 kegg serum_cytokines NA 0.65 no no no no no no Hepatitis B FGF basic 0 0 -0.406130268 kegg serum_cytokines NA 0.65 no no no no no no Hepatitis C FGF basic 0 0.493233083 0 kegg serum_cytokines NA 0.65 no no no no no no Hippo signaling pathway FGF basic 0 0 0.524356869 kegg serum_cytokines NA 0.65 no no no no no no Human papillomavirus infection FGF basic -0.741758242 0 0 kegg serum_cytokines NA 0.65 no no no no no no Huntington disease FGF basic 0.846153846 0 0 kegg serum_cytokines NA 0.65 no no no no no no Hypertrophic cardiomyopathy FGF basic 0 0 0.451559934 kegg serum_cytokines NA 0.65 no up up no no no Insulin resistance FGF basic 0 0 -0.629994527 kegg serum_cytokines NA 0.65 no no no no no no Insulin secretion FGF basic 0 0 -0.449370553 yes kegg serum_cytokines NA 0.65 no up up no no no L-Alanine+blood FGF basic 0 0 -0.464661654 yes serum_aminoacids serum_cytokines 0.00138 0.65 up up no no no no L-Homocystine+blood FGF basic 0.648484848 0 0 serum_aminoacids serum_cytokines 0.197 0.65 no no no no no no L-Tryptophan+urine FGF basic 0.672727273 0 0 urine_cometabolism serum_cytokines 0.226 0.65 no no no no no no Leukocyte transendothelial migration FGF basic 0 0 0.474001095 kegg serum_cytokines NA 0.65 no no no no no no Longevity regulating pathway - multiple species FGF basic 0 0 0.405582923 kegg serum_cytokines NA 0.65 no no no no no no mRNA surveillance pathway FGF basic 0.67032967 0 0 kegg serum_cytokines NA 0.65 no no no no no no n3+blood FGF basic 0 -0.514285714 0 serum_fattyacid serum_cytokines 0.806 0.65 no no no no no no Natural killer cell mediated cytotoxicity FGF basic -0.615384615 0 0 kegg serum_cytokines NA 0.65 no no no no no no Neurotrophin signaling pathway FGF basic 0 0.587969925 0 kegg serum_cytokines NA 0.65 no no no no no no NF-kappa B signaling pathway FGF basic 0 0 -0.528188287 kegg serum_cytokines NA 0.65 no no no no no no Non-alcoholic fatty liver disease FGF basic 0.747252747 0 0 kegg serum_cytokines NA 0.65 no no no no no no Oxidative phosphorylation FGF basic 0.868131868 0 0 kegg serum_cytokines NA 0.65 no no no no no no P-hydroxyhippuric acid+urine FGF basic -0.636363636 0 0 urine_cometabolism serum_cytokines 0.436 0.65 no no no no no no "Parathyroid hormone synthesis, secretion and action" FGF basic 0 0 -0.515599343 kegg serum_cytokines NA 0.65 no no no no no no Parkinson disease FGF basic 0.653846154 0 0 kegg serum_cytokines NA 0.65 no no no no no no Pathways of neurodegeneration - multiple diseases FGF basic 0.653846154 0 0 kegg serum_cytokines NA 0.65 no no no no no no Phagosome FGF basic -0.747252747 0 0 kegg serum_cytokines NA 0.65 no no no no no no Primary immunodeficiency FGF basic 0 -0.481203008 0.496442255 kegg serum_cytokines NA 0.65 no no no no no no Prion disease FGF basic 0.835164835 0 0 kegg serum_cytokines NA 0.65 no no no no no no Prostate cancer FGF basic 0 0.544360902 -0.556102901 kegg serum_cytokines NA 0.65 no no no no no no Regulation of actin cytoskeleton FGF basic 0 0 0.42364532 kegg serum_cytokines NA 0.65 no no no no no no Relaxin signaling pathway FGF basic 0 0.488721805 -0.571975917 kegg serum_cytokines NA 0.65 no no no no no no Retrograde endocannabinoid signaling FGF basic 0.774725275 0 0 kegg serum_cytokines NA 0.65 no no up no no no Rheumatoid arthritis FGF basic 0 0 0.562671045 kegg serum_cytokines NA 0.65 no no no no no no Ribosome biogenesis in eukaryotes FGF basic 0 -0.473684211 0 kegg serum_cytokines NA 0.65 no no no no no no RIG-I-like receptor signaling pathway FGF basic 0 0 -0.48877942 kegg serum_cytokines NA 0.65 no no no no no no RNA degradation FGF basic 0.631868132 0 0 kegg serum_cytokines NA 0.65 no no no no no no Ruminococcus FGF basic 0 0 -0.401896275 Genus serum_cytokines 0.0679 0.65 no no dn no no no Salmonella infection FGF basic 0 0 0.4969896 kegg serum_cytokines NA 0.65 no no no no no no Sarcina FGF basic 0 0.458682472 0 Genus serum_cytokines 0.0703 0.65 no no no no no no Sarcosine+blood FGF basic 0 0 -0.455639098 serum_choline serum_cytokines 5.06E-05 0.65 up up no no no no Small cell lung cancer FGF basic 0 0.454135338 -0.65681445 kegg serum_cytokines NA 0.65 no no up no no no Sphingolipid signaling pathway FGF basic 0 0.530827068 0 kegg serum_cytokines NA 0.65 no no no no no no TCA+blood FGF basic 0 0 0.449941231 serum_bileacids serum_cytokines 0.339 0.65 no no no no no no Thermogenesis FGF basic 0.758241758 0 0 kegg serum_cytokines NA 0.65 no no no no no no Tight junction FGF basic 0 0 0.425834702 kegg serum_cytokines NA 0.65 no no no no no no Transcriptional misregulation in cancer FGF basic 0 0 -0.528735632 kegg serum_cytokines NA 0.65 no no no no no no TXB2+blood FGF basic -0.911858316 0 0 yes serum_ARA serum_cytokines 0.0644 0.65 dn no no no no no Type I diabetes mellitus FGF basic -0.78021978 0 0 kegg serum_cytokines NA 0.65 no no no no no no Viral carcinogenesis FGF basic -0.587912088 0 0 kegg serum_cytokines NA 0.65 no no no no no no Viral myocarditis FGF basic -0.752747253 0 0 kegg serum_cytokines NA 0.65 no no no no no no Corynebacterium Finegoldia 0 0.400240341 0 Genus Genus 0.216 0.456 no no no no no no Eggerthella Finegoldia 0 0.468989962 0 Genus Genus 0.912 0.456 no no no no no no ABC transporters Fluid shear stress and atherosclerosis 0 -0.62055336 0 kegg kegg NA NA no up up no no no Adherens junction Fluid shear stress and atherosclerosis 0.833043478 0.774703557 0.836808237 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Fluid shear stress and atherosclerosis 0 -0.511857708 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Fluid shear stress and atherosclerosis 0 -0.453557312 0 kegg kegg NA NA no no no no no no Anaerostipes Fluid shear stress and atherosclerosis 0 -0.483052842 0 butyrate-producing Genus kegg 0.568 NA no no no no no no Apelin signaling pathway Fluid shear stress and atherosclerosis -0.42173913 0 0 kegg kegg NA NA no no no no no no Apoptosis Fluid shear stress and atherosclerosis 0.540869565 0 0.70990991 kegg kegg NA NA no no no no no no Apoptosis - multiple species Fluid shear stress and atherosclerosis -0.682608696 -0.662055336 -0.404118404 kegg kegg NA NA no no no no no no Arrhythmogenic right ventricular cardiomyopathy Fluid shear stress and atherosclerosis 0.771304348 0.714426877 0.818790219 kegg kegg NA NA no up up no no no Asthma Fluid shear stress and atherosclerosis 0 0.503952569 0 kegg kegg NA NA no no no no no no Autophagy - animal Fluid shear stress and atherosclerosis -0.433913043 -0.579051383 0 kegg kegg NA NA no no no no no no Autophagy - other Fluid shear stress and atherosclerosis -0.64173913 -0.825098814 -0.679279279 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Fluid shear stress and atherosclerosis 0.802608696 0.877470356 0.823680824 kegg kegg NA NA no no no no no no Basal cell carcinoma Fluid shear stress and atherosclerosis 0 -0.528656126 -0.542857143 kegg kegg NA NA no no no no no no Basal transcription factors Fluid shear stress and atherosclerosis -0.573043478 0 -0.606177606 kegg kegg NA NA no no no no no no Base excision repair Fluid shear stress and atherosclerosis -0.669565217 -0.4743083 -0.47027027 kegg kegg NA NA no no no no no no beta-Alanine metabolism Fluid shear stress and atherosclerosis 0 0.509881423 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Fluid shear stress and atherosclerosis 0 0 0.496525097 kegg kegg NA NA no no no no no no Breast cancer Fluid shear stress and atherosclerosis 0 -0.519762846 0 kegg kegg NA NA no no no no no no Butyricicoccus Fluid shear stress and atherosclerosis -0.518542838 0 0 butyrate-producing Genus kegg 0.852 NA no no no no no no Carbohydrate digestion and absorption Fluid shear stress and atherosclerosis 0 -0.420948617 0 kegg kegg NA NA no no no no no no Carbon metabolism Fluid shear stress and atherosclerosis 0 0.70256917 0.547490347 kegg kegg NA NA no no no no no no Cell adhesion molecules Fluid shear stress and atherosclerosis 0 0 0.42985843 kegg kegg NA NA no no no no no no Cell cycle Fluid shear stress and atherosclerosis 0 0 -0.473101673 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Fluid shear stress and atherosclerosis 0 0 0.528700129 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Fluid shear stress and atherosclerosis 0 -0.461462451 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Fluid shear stress and atherosclerosis 0 0 0.447361647 kegg kegg NA NA no no no no no no Choline metabolism in cancer Fluid shear stress and atherosclerosis 0 -0.460474308 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Fluid shear stress and atherosclerosis -0.428695652 -0.43083004 0 kegg kegg NA NA no no no no no no Circadian entrainment Fluid shear stress and atherosclerosis 0.48173913 0.495059289 0 kegg kegg NA NA no up up no no no Circadian rhythm Fluid shear stress and atherosclerosis 0 -0.566205534 -0.672329472 kegg kegg NA NA no no no no no no Clostridium Fluid shear stress and atherosclerosis 0 0.42993591 0 Genus kegg 0.925 NA no no no no no no Collecting duct acid secretion Fluid shear stress and atherosclerosis 0.497391304 0.513833992 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Fluid shear stress and atherosclerosis 0 0 0.586100386 kegg kegg NA NA no no no no no no Cushing syndrome Fluid shear stress and atherosclerosis 0 -0.493083004 -0.44015444 kegg kegg NA NA no no up no no no Cytokine-cytokine receptor interaction Fluid shear stress and atherosclerosis 0 0 0.529214929 kegg kegg NA NA no no no no no no Dilated cardiomyopathy Fluid shear stress and atherosclerosis 0.746086957 0.650197628 0.641441441 kegg kegg NA NA no up up no no no Drug metabolism - other enzymes Fluid shear stress and atherosclerosis 0 0.421936759 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Fluid shear stress and atherosclerosis -0.55826087 0 0 kegg kegg NA NA no no no no no no Endometrial cancer Fluid shear stress and atherosclerosis 0 -0.519762846 -0.455341055 kegg kegg NA NA no no no no no no ErbB signaling pathway Fluid shear stress and atherosclerosis 0 -0.540513834 0 kegg kegg NA NA no no no no no no Eubacterium Fluid shear stress and atherosclerosis 0 0 -0.407286627 Genus kegg 0.0692 NA no no no no no no Fanconi anemia pathway Fluid shear stress and atherosclerosis 0 0 -0.42960103 kegg kegg NA NA no no no no no no Fatty acid elongation Fluid shear stress and atherosclerosis 0 0.462450593 0 kegg kegg NA NA no no no no no no Focal adhesion Fluid shear stress and atherosclerosis 0.776521739 0.796442688 0.709395109 kegg kegg NA NA no up up no no no FoxO signaling pathway Fluid shear stress and atherosclerosis 0 -0.506916996 0 kegg kegg NA NA no no no no no no Gastric acid secretion Fluid shear stress and atherosclerosis 0.820869565 0.68972332 0.754954955 kegg kegg NA NA no no no no no no Gastric cancer Fluid shear stress and atherosclerosis 0 -0.586956522 -0.467953668 kegg kegg NA NA no no no no no no Glucagon signaling pathway Fluid shear stress and atherosclerosis 0 0 -0.574774775 kegg kegg NA NA no no no no no no Glycerolipid metabolism Fluid shear stress and atherosclerosis 0 -0.518774704 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Fluid shear stress and atherosclerosis 0 -0.614624506 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Fluid shear stress and atherosclerosis 0 0.488142292 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Fluid shear stress and atherosclerosis 0.405217391 0 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - globo and isoglobo series Fluid shear stress and atherosclerosis 0.454782609 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Fluid shear stress and atherosclerosis -0.410434783 -0.470355731 -0.417245817 kegg kegg NA NA no no no no no no GnRH secretion Fluid shear stress and atherosclerosis 0 -0.532608696 0 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Fluid shear stress and atherosclerosis 0 -0.436758893 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Fluid shear stress and atherosclerosis 0 0.464426877 0.471299871 kegg kegg NA NA no no no no no no Hepatitis B Fluid shear stress and atherosclerosis 0 -0.500988142 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Fluid shear stress and atherosclerosis 0.779130435 0.678853755 0.742342342 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Fluid shear stress and atherosclerosis -0.59826087 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Fluid shear stress and atherosclerosis 0.730434783 0.627470356 0.665637066 kegg kegg NA NA no no no no no no Histidine metabolism Fluid shear stress and atherosclerosis 0 0 0.432689833 kegg kegg NA NA no no no no no no Homologous recombination Fluid shear stress and atherosclerosis 0 -0.585968379 -0.482882883 kegg kegg NA NA no no no no no no Hypertrophic cardiomyopathy Fluid shear stress and atherosclerosis 0.740869565 0.785573123 0.835263835 kegg kegg NA NA no up up no no no Influenza A Fluid shear stress and atherosclerosis 0.444347826 0.463438735 0.82033462 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Fluid shear stress and atherosclerosis 0 -0.513833992 0 kegg kegg NA NA no no no no no no Insulin resistance Fluid shear stress and atherosclerosis -0.495652174 -0.505928854 -0.564993565 kegg kegg NA NA no no no no no no Insulin signaling pathway Fluid shear stress and atherosclerosis -0.500869565 0 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Fluid shear stress and atherosclerosis 0 -0.5256917 0 kegg kegg NA NA no no no no no no Lachnospira Fluid shear stress and atherosclerosis 0 0.691376349 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Leukocyte transendothelial migration Fluid shear stress and atherosclerosis 0.728695652 0.78458498 0.792535393 kegg kegg NA NA no no no no no no Long-term potentiation Fluid shear stress and atherosclerosis 0 0 -0.445302445 kegg kegg NA NA no no up no no no Longevity regulating pathway Fluid shear stress and atherosclerosis 0 -0.650197628 0 kegg kegg NA NA no no no no no no Lysine degradation Fluid shear stress and atherosclerosis -0.676521739 -0.635375494 -0.456885457 kegg kegg NA NA no no no no no no Lysosome Fluid shear stress and atherosclerosis 0 0.479249012 0.460746461 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Fluid shear stress and atherosclerosis 0 -0.528656126 -0.423423423 kegg kegg NA NA no no no no no no Melanoma Fluid shear stress and atherosclerosis 0 -0.4743083 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Fluid shear stress and atherosclerosis 0 0 0.401544402 kegg kegg NA NA no no no no no no MicroRNAs in cancer Fluid shear stress and atherosclerosis 0 -0.563241107 -0.413127413 kegg kegg NA NA no no no no no no mRNA surveillance pathway Fluid shear stress and atherosclerosis 0 0 -0.550579151 kegg kegg NA NA no no no no no no mTOR signaling pathway Fluid shear stress and atherosclerosis -0.537391304 0 -0.45045045 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Fluid shear stress and atherosclerosis 0 -0.505928854 -0.428828829 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Fluid shear stress and atherosclerosis 0.437391304 0.43083004 0.430630631 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Fluid shear stress and atherosclerosis 0.479130435 0.450592885 0.676705277 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Fluid shear stress and atherosclerosis 0 -0.4743083 -0.402831403 kegg kegg NA NA no no no no no no Nicotine addiction Fluid shear stress and atherosclerosis 0 -0.504940711 0 kegg kegg NA NA no up up no no no Non-small cell lung cancer Fluid shear stress and atherosclerosis 0 -0.53458498 0 kegg kegg NA NA no no no no no no Other glycan degradation Fluid shear stress and atherosclerosis 0 -0.42687747 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Fluid shear stress and atherosclerosis -0.55826087 -0.668972332 -0.496010296 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Fluid shear stress and atherosclerosis 0.848695652 0.885375494 0.705019305 kegg kegg NA NA no no no no no no p53 signaling pathway Fluid shear stress and atherosclerosis -0.693043478 -0.772727273 -0.635263835 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Fluid shear stress and atherosclerosis 0.486956522 0.540513834 0.808751609 kegg kegg NA NA no no no no no no Pathways in cancer Fluid shear stress and atherosclerosis 0 -0.530632411 -0.607722008 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Fluid shear stress and atherosclerosis 0 -0.497035573 -0.48957529 kegg kegg NA NA no no no no no no Pentose phosphate pathway Fluid shear stress and atherosclerosis 0 0.472332016 0 kegg kegg NA NA no no no no no no Pertussis Fluid shear stress and atherosclerosis 0 0 0.458944659 kegg kegg NA NA no no dn no no no Phagosome Fluid shear stress and atherosclerosis 0 0.488142292 0.645302445 kegg kegg NA NA no no no no no no Phenylalanine metabolism Fluid shear stress and atherosclerosis 0.439130435 0.531620553 0.482110682 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Fluid shear stress and atherosclerosis 0 0 -0.416473616 kegg kegg NA NA no no no no no no Phototransduction Fluid shear stress and atherosclerosis 0 0.574110672 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Fluid shear stress and atherosclerosis 0 0 -0.423680824 yes kegg kegg NA NA no up up no no no Platelet activation Fluid shear stress and atherosclerosis 0.873043478 0.830039526 0.783268983 kegg kegg NA NA no no no no no no Platinum drug resistance Fluid shear stress and atherosclerosis -0.662608696 -0.671936759 -0.435263835 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Fluid shear stress and atherosclerosis 0 0.451581028 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Fluid shear stress and atherosclerosis 0 -0.583992095 -0.407464607 kegg kegg NA NA no no no no no no Prostate cancer Fluid shear stress and atherosclerosis 0 -0.455533597 -0.441441441 kegg kegg NA NA no no no no no no Protein export Fluid shear stress and atherosclerosis -0.448695652 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Fluid shear stress and atherosclerosis 0 0 -0.42985843 kegg kegg NA NA no no no no no no Rap1 signaling pathway Fluid shear stress and atherosclerosis 0.853043478 0.813241107 0.798455598 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Fluid shear stress and atherosclerosis 0.64 0.675889328 0.491634492 kegg kegg NA NA no no no no no no Renal cell carcinoma Fluid shear stress and atherosclerosis 0 0 -0.598970399 kegg kegg NA NA no no no no no no Rheumatoid arthritis Fluid shear stress and atherosclerosis 0 0 0.574002574 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Fluid shear stress and atherosclerosis -0.607826087 0 -0.466924067 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Fluid shear stress and atherosclerosis -0.42 -0.507905138 0 kegg kegg NA NA no no no no no no RNA degradation Fluid shear stress and atherosclerosis 0 0 -0.476962677 kegg kegg NA NA no no no no no no RNA polymerase Fluid shear stress and atherosclerosis -0.696521739 0 0 kegg kegg NA NA no no no no no no RNA transport Fluid shear stress and atherosclerosis -0.51826087 0 0 kegg kegg NA NA no no no no no no Roseburia Fluid shear stress and atherosclerosis 0.439130435 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Salivary secretion Fluid shear stress and atherosclerosis 0 0.585968379 0 kegg kegg NA NA no no no no no no Salmonella infection Fluid shear stress and atherosclerosis 0 0.507905138 0.712741313 kegg kegg NA NA no no no no no no Selenocompound metabolism Fluid shear stress and atherosclerosis -0.609565217 -0.506916996 0 kegg kegg NA NA no no no no no no Serotonergic synapse Fluid shear stress and atherosclerosis 0.5 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Fluid shear stress and atherosclerosis 0 -0.690711462 -0.465637066 kegg kegg NA NA no no no no no no Small cell lung cancer Fluid shear stress and atherosclerosis -0.587826087 -0.522727273 -0.578893179 kegg kegg NA NA no no up no no no SNARE interactions in vesicular transport Fluid shear stress and atherosclerosis 0 -0.5256917 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Fluid shear stress and atherosclerosis 0.413043478 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Fluid shear stress and atherosclerosis -0.609565217 0 -0.407722008 kegg kegg NA NA no no no no no no Spliceosome Fluid shear stress and atherosclerosis -0.724347826 -0.785573123 -0.622136422 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Fluid shear stress and atherosclerosis 0 0.4743083 0.601544402 kegg kegg NA NA up no no no no no Synaptic vesicle cycle Fluid shear stress and atherosclerosis 0.459130435 0.469367589 0.414157014 kegg kegg NA NA no up up no no no Systemic lupus erythematosus Fluid shear stress and atherosclerosis 0 0.429841897 0.457915058 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Fluid shear stress and atherosclerosis 0 -0.609683794 -0.534105534 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Fluid shear stress and atherosclerosis 0 -0.649209486 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Fluid shear stress and atherosclerosis 0.74173913 0.596837945 0.672586873 kegg kegg NA NA no no no no no no Tight junction Fluid shear stress and atherosclerosis 0.709565217 0.785573123 0.744658945 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Fluid shear stress and atherosclerosis -0.604347826 -0.592885375 -0.625482625 kegg kegg NA NA no no no no no no Tuberculosis Fluid shear stress and atherosclerosis 0 0 0.615444015 kegg kegg NA NA no no dn no no no Type II diabetes mellitus Fluid shear stress and atherosclerosis 0 -0.557312253 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Fluid shear stress and atherosclerosis -0.439130435 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Fluid shear stress and atherosclerosis 0.854782609 0.732213439 0.81981982 kegg kegg NA NA no no no no no no Viral myocarditis Fluid shear stress and atherosclerosis 0 0.428853755 0.545688546 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Fluid shear stress and atherosclerosis 0 0.415019763 0 kegg kegg NA NA no no no no no no Yersinia infection Fluid shear stress and atherosclerosis 0.715652174 0.540513834 0.796396396 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Focal adhesion 0 0.513833992 0 kegg kegg NA NA no no no no up up ABC transporters Focal adhesion 0 -0.625494071 0 kegg kegg NA NA no up up no up up "Alanine, aspartate and glutamate metabolism" Focal adhesion -0.409565217 -0.65513834 0 kegg kegg NA NA no no no no up up Apelin signaling pathway Focal adhesion -0.408695652 0.497035573 0 kegg kegg NA NA no no no no up up Apoptosis Focal adhesion 0.476521739 0 0 kegg kegg NA NA no no no no up up Apoptosis - multiple species Focal adhesion -0.559130435 -0.633399209 0 kegg kegg NA NA no no no no up up Arginine and proline metabolism Focal adhesion 0 -0.543478261 -0.405662806 kegg kegg NA NA no up no no up up Arginine biosynthesis Focal adhesion 0 -0.579051383 0 kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism Focal adhesion 0 0.436758893 0 kegg kegg NA NA no no no no up up Autophagy - animal Focal adhesion -0.709565217 -0.878458498 0 kegg kegg NA NA no no no no up up Autophagy - other Focal adhesion -0.770434783 -0.787549407 0 kegg kegg NA NA no no no no up up Basal transcription factors Focal adhesion -0.606956522 0 0 kegg kegg NA NA no no no no up up Base excision repair Focal adhesion -0.453043478 0 0 kegg kegg NA NA no no no no up up beta-Alanine metabolism Focal adhesion 0 0.572134387 0 kegg kegg NA NA no no no no up up Bifidobacterium Focal adhesion 0 0.44675719 0 acetate-producing Genus kegg 0.105 NA no dn no no up up Biosynthesis of unsaturated fatty acids Focal adhesion 0 0 0.456885457 kegg kegg NA NA no no no no up up Butanoate metabolism Focal adhesion 0 0.577075099 0 kegg kegg NA NA no no no no up up Butyricicoccus Focal adhesion -0.48173604 0 0 butyrate-producing Genus kegg 0.852 NA no no no no up up Carbon metabolism Focal adhesion 0.43826087 0.604743083 0 kegg kegg NA NA no no no no up up Cardiac muscle contraction Focal adhesion 0 0.530632411 0.502187902 kegg kegg NA NA no no up no up up Citrate cycle (TCA cycle) Focal adhesion 0 0.583992095 0 kegg kegg NA NA no no no no up up Clostridium Focal adhesion 0 0.439105159 0 Genus kegg 0.925 NA no no no no up up Cysteine and methionine metabolism Focal adhesion 0 0.514822134 0 kegg kegg NA NA no no no no up up Cytokine-cytokine receptor interaction Focal adhesion 0 0 0.633204633 kegg kegg NA NA no no no no up up DNA replication Focal adhesion 0 0.416007905 0 kegg kegg NA NA no no no no up up Drug metabolism - cytochrome P450 Focal adhesion 0 0.673913043 0 kegg kegg NA NA no no no no up up Drug metabolism - other enzymes Focal adhesion 0 0.803359684 0 kegg kegg NA NA no no no no up up EGFR tyrosine kinase inhibitor resistance Focal adhesion -0.460869565 0 0 kegg kegg NA NA no no no no up up ErbB signaling pathway Focal adhesion 0 -0.615612648 0 kegg kegg NA NA no no no no up up Fatty acid biosynthesis Focal adhesion 0 -0.56027668 0 kegg kegg NA NA no no no no up up Fatty acid degradation Focal adhesion 0 -0.48715415 0 kegg kegg NA NA no no no no up up Fatty acid elongation Focal adhesion 0.431304348 0.555335968 0 kegg kegg NA NA no no no no up up FoxO signaling pathway Focal adhesion 0 -0.721343874 0 kegg kegg NA NA no no no no up up Fructose and mannose metabolism Focal adhesion 0 -0.45256917 0 kegg kegg NA NA no no no no up up Glycerolipid metabolism Focal adhesion 0 -0.648221344 0 kegg kegg NA NA no no up no up up Glycerophospholipid metabolism Focal adhesion -0.590434783 -0.707509881 0 kegg kegg NA NA no no up no up up Glycolysis / Gluconeogenesis Focal adhesion 0 0.72826087 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Focal adhesion 0 -0.711462451 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Focal adhesion 0.614782609 0 0 kegg kegg NA NA no no no no up up Glyoxylate and dicarboxylate metabolism Focal adhesion 0 -0.570158103 0 kegg kegg NA NA no no no no up up HIF-1 signaling pathway Focal adhesion -0.527826087 0.479249012 0 kegg kegg NA NA no no no no up up Hippo signaling pathway Focal adhesion 0.910434783 0.914031621 0.958558559 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Focal adhesion 0 -0.493083004 0 kegg kegg NA NA no no no no up up Homologous recombination Focal adhesion 0 -0.490118577 0 kegg kegg NA NA no no no no up up Inositol phosphate metabolism Focal adhesion 0 -0.60770751 0 kegg kegg NA NA no no no no up up Lachnospira Focal adhesion 0 0.565851265 0 butyrate-producing Genus kegg 0.279 NA no no no no up up Longevity regulating pathway Focal adhesion -0.410434783 -0.615612648 0 kegg kegg NA NA no no no no up up Lysine degradation Focal adhesion -0.479130435 0 0 kegg kegg NA NA no no no no up up MAPK signaling pathway Focal adhesion 0 -0.553359684 0 kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 Focal adhesion 0 0.735177866 0 kegg kegg NA NA no no no no up up Mitophagy - animal Focal adhesion 0 0 -0.424967825 kegg kegg NA NA no no no no up up mRNA surveillance pathway Focal adhesion -0.459130435 0 0 kegg kegg NA NA no no no no up up mTOR signaling pathway Focal adhesion -0.445217391 0 0 kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis Focal adhesion 0 -0.508893281 0 kegg kegg NA NA no no no no up up N-Glycan biosynthesis Focal adhesion 0 0.467391304 0 kegg kegg NA NA no no no no up up NF-kappa B signaling pathway Focal adhesion -0.410434783 -0.77173913 -0.664607465 kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Focal adhesion 0 -0.516798419 0 kegg kegg NA NA no no no no up up Nitrogen metabolism Focal adhesion 0 -0.592885375 0 kegg kegg NA NA no no no no up up Non-homologous end-joining Focal adhesion 0 0.536561265 0 kegg kegg NA NA no no no no up up Notch signaling pathway Focal adhesion 0 -0.492094862 0 kegg kegg NA NA no no no no up up Oocyte meiosis Focal adhesion 0 0.545454545 0 kegg kegg NA NA no no no no up up Oscillospira Focal adhesion 0 -0.41798419 0 LPS-producing Genus kegg 0.62 NA no no no no up up Other glycan degradation Focal adhesion 0 -0.502964427 0 kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis Focal adhesion -0.554782609 -0.47826087 0 kegg kegg NA NA no no no no up up Oxidative phosphorylation Focal adhesion 0 0.544466403 0.478507079 kegg kegg NA NA no no no no up up p53 signaling pathway Focal adhesion -0.705217391 -0.72826087 0 kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis Focal adhesion 0 -0.434782609 0 kegg kegg NA NA no no dn no up up Pentose and glucuronate interconversions Focal adhesion 0 0.539525692 0 kegg kegg NA NA no no no no up up Peroxisome Focal adhesion 0 -0.481225296 0 kegg kegg NA NA no no no no up up Phagosome Focal adhesion 0.466956522 0 0 kegg kegg NA NA no no no no up up Phenylalanine metabolism Focal adhesion 0.653913043 0.716403162 0.506563707 kegg kegg NA NA no no no no up up Phospholipase D signaling pathway Focal adhesion 0 -0.585968379 0 kegg kegg NA NA no up up no up up Platinum drug resistance Focal adhesion -0.553043478 -0.586956522 0 kegg kegg NA NA no no no no up up PPAR signaling pathway Focal adhesion 0 -0.515810277 0 kegg kegg NA NA no no no no up up Prevotella Focal adhesion 0 -0.459481269 0 acetate-producing Genus kegg 0.287 NA no no no no up up Primary bile acid biosynthesis Focal adhesion 0 0.494071146 0 kegg kegg NA NA no no no no up up Propanoate metabolism Focal adhesion 0 0.498023715 0 kegg kegg NA NA no no no no up up Proteasome Focal adhesion -0.516521739 0.613636364 0 kegg kegg NA NA no no no no up up Protein export Focal adhesion -0.436521739 0.551383399 0 kegg kegg NA NA no no no no up up Purine metabolism Focal adhesion 0 0 -0.527155727 kegg kegg NA NA no no no no up up Pyrimidine metabolism Focal adhesion 0 0.467391304 0 kegg kegg NA NA no no no no up up Pyruvate metabolism Focal adhesion 0 0.495059289 0 kegg kegg NA NA no no no no up up Rap1 signaling pathway Focal adhesion 0.824347826 0.804347826 0.71969112 kegg kegg NA NA no no no no up up Ras signaling pathway Focal adhesion 0 0.584980237 0 yes kegg kegg NA NA no up up no up up Ribosome Focal adhesion 0 0.477272727 0 kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes Focal adhesion -0.428695652 0 0 kegg kegg NA NA no no no no up up RNA polymerase Focal adhesion -0.583478261 0 0 kegg kegg NA NA no no no no up up Selenocompound metabolism Focal adhesion -0.663478261 -0.415019763 0 kegg kegg NA NA no no no no up up SNARE interactions in vesicular transport Focal adhesion 0 -0.681818182 0 kegg kegg NA NA no no no no up up Sphingolipid signaling pathway Focal adhesion 0 0 0.431660232 kegg kegg NA NA no no no no up up Spliceosome Focal adhesion -0.606956522 -0.613636364 0 kegg kegg NA NA no no no no up up Starch and sucrose metabolism Focal adhesion 0 -0.476284585 0 kegg kegg NA NA no no no no up up Steroid hormone biosynthesis Focal adhesion 0 0.473320158 0 kegg kegg NA NA no no no no up up Taurine and hypotaurine metabolism Focal adhesion -0.444347826 -0.736166008 0 kegg kegg NA NA no no no no up up TGF-beta signaling pathway Focal adhesion 0 0.584980237 0 kegg kegg NA NA no no no no up up Thiamine metabolism Focal adhesion 0 0 -0.482110682 kegg kegg NA NA no no no no up up Tryptophan metabolism Focal adhesion 0 0.583003953 0 kegg kegg NA NA no up no no up up Tyrosine metabolism Focal adhesion 0 0.583992095 0 kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" Focal adhesion 0 0.475296443 0 kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Focal adhesion 0 0.595849802 0 kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor Focal adhesion 0 0 0.438352638 kegg kegg NA NA no no no no up up Wnt signaling pathway Focal adhesion 0 0.42687747 0 kegg kegg NA NA no no no no up up "Alanine, aspartate and glutamate metabolism" Folate biosynthesis 0 -0.7243083 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Folate biosynthesis 0 -0.608695652 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Folate biosynthesis 0 -0.592885375 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Folate biosynthesis 0 -0.765810277 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Folate biosynthesis 0 0.519762846 0 kegg kegg NA NA no no no no no no Butanoate metabolism Folate biosynthesis 0 0.453557312 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Folate biosynthesis 0 0.450592885 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Folate biosynthesis 0.456521739 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Folate biosynthesis 0 0.555335968 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Folate biosynthesis 0 -0.677865613 0 kegg kegg NA NA no no no no no no Fatty acid degradation Folate biosynthesis 0 -0.513833992 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Folate biosynthesis 0 0 0.419047619 kegg kegg NA NA no no up no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Folate biosynthesis 0 0.657114625 0.426512227 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Folate biosynthesis 0 0.714426877 0.564221364 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Folate biosynthesis 0 -0.745059289 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Folate biosynthesis 0.406086957 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Folate biosynthesis 0 0.575098814 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Folate biosynthesis 0 0.766798419 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Folate biosynthesis 0 -0.693675889 0 kegg kegg NA NA no no no no no no One carbon pool by folate Folate biosynthesis 0 0.447628458 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Folate biosynthesis 0.44173913 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Folate biosynthesis 0 0.445652174 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Folate biosynthesis 0 -0.663043478 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Folate biosynthesis 0.473913043 0.630434783 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Folate biosynthesis 0 -0.500988142 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Folate biosynthesis 0 0.427865613 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Folate biosynthesis 0 0.427865613 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Folate biosynthesis 0.424347826 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Folate biosynthesis 0 -0.578063241 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Folate biosynthesis 0 0 0.624710425 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Folate biosynthesis 0.46173913 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Folate biosynthesis 0.582608696 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Folate biosynthesis 0.493913043 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Folate biosynthesis 0 0.423913043 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Folate biosynthesis 0 0.744071146 0 kegg kegg NA NA no no no no no no ABC transporters FoxO signaling pathway 0 0.744071146 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" FoxO signaling pathway 0.493913043 0.645256917 0 kegg kegg NA NA no no no no no no Alistipes FoxO signaling pathway -0.558083924 0 0 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism FoxO signaling pathway 0 0.68972332 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis FoxO signaling pathway 0 0 0.4002574 kegg kegg NA NA no no no no no no Arachidonic acid metabolism FoxO signaling pathway -0.465217391 0 -0.428056628 kegg kegg NA NA no no no no no no Arginine and proline metabolism FoxO signaling pathway 0 0.494071146 0 kegg kegg NA NA no up no no no no Arginine biosynthesis FoxO signaling pathway 0.46173913 0.567193676 0 kegg kegg NA NA no no no no no no Basal transcription factors FoxO signaling pathway 0 0 0.504504505 kegg kegg NA NA no no no no no no Base excision repair FoxO signaling pathway 0 0 0.49034749 kegg kegg NA NA no no no no no no Bifidobacterium FoxO signaling pathway 0 -0.422487675 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Biosynthesis of cofactors FoxO signaling pathway -0.475652174 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway FoxO signaling pathway 0 -0.514822134 0 kegg kegg NA NA no up up no no no cGMP-PKG signaling pathway FoxO signaling pathway 0.586086957 0 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway FoxO signaling pathway 0 0 -0.406949807 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) FoxO signaling pathway 0 -0.442687747 0 kegg kegg NA NA no no no no no no Clostridium FoxO signaling pathway 0 -0.486989016 0 Genus kegg 0.925 NA no no no no no no Cysteine and methionine metabolism FoxO signaling pathway 0 0 0.428314028 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction FoxO signaling pathway 0.477391304 0 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 FoxO signaling pathway 0 -0.538537549 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes FoxO signaling pathway 0 -0.716403162 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance FoxO signaling pathway 0 -0.536561265 0 kegg kegg NA NA no no no no no no ErbB signaling pathway FoxO signaling pathway 0 0.657114625 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway FoxO signaling pathway 0 0 0.565508366 kegg kegg NA NA no no no no no no Fatty acid biosynthesis FoxO signaling pathway 0.584347826 0.691699605 0 kegg kegg NA NA no no no no no no Fatty acid degradation FoxO signaling pathway 0.48173913 0.716403162 0 kegg kegg NA NA no no no no no no Fatty acid metabolism FoxO signaling pathway 0 0.62944664 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism FoxO signaling pathway 0 0.505928854 0 kegg kegg NA NA no no no no no no Galactose metabolism FoxO signaling pathway 0 0.719367589 0 kegg kegg NA NA no no no no no no Glutathione metabolism FoxO signaling pathway -0.586956522 -0.60770751 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism FoxO signaling pathway 0 0.825098814 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism FoxO signaling pathway 0 0.650197628 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" FoxO signaling pathway -0.579130435 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis FoxO signaling pathway 0 -0.614624506 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate FoxO signaling pathway 0 0.747035573 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series FoxO signaling pathway -0.446956522 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis FoxO signaling pathway 0.443478261 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism FoxO signaling pathway 0 0.537549407 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway FoxO signaling pathway 0 -0.615612648 0 kegg kegg NA NA no no no no no no Homologous recombination FoxO signaling pathway 0.496521739 0.482213439 0.628828829 kegg kegg NA NA no no no no no no Inositol phosphate metabolism FoxO signaling pathway 0.411304348 0.770750988 0.500643501 kegg kegg NA NA no no no no no no Lachnospira FoxO signaling pathway 0 -0.490239699 0 butyrate-producing Genus kegg 0.279 NA no no no no no no MAPK signaling pathway FoxO signaling pathway 0.696521739 0.710474308 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 FoxO signaling pathway 0 -0.550395257 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis FoxO signaling pathway 0 0.491106719 0.507335907 kegg kegg NA NA no no no no no no N-Glycan biosynthesis FoxO signaling pathway 0 0 0.491634492 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway FoxO signaling pathway 0.520869565 0.668972332 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism FoxO signaling pathway 0.51826087 0.604743083 0 kegg kegg NA NA no no no no no no Nitrogen metabolism FoxO signaling pathway 0 0.454545455 0 kegg kegg NA NA no no no no no no Nucleotide excision repair FoxO signaling pathway 0 0 0.511196911 kegg kegg NA NA no no no no no no Oscillospira FoxO signaling pathway 0 0.533596838 0 LPS-producing Genus kegg 0.62 NA no no no no no no Other glycan degradation FoxO signaling pathway 0 0.54743083 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis FoxO signaling pathway 0 0 0.459202059 kegg kegg NA NA no no no no no no Oxidative phosphorylation FoxO signaling pathway 0 -0.765810277 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis FoxO signaling pathway 0.69826087 0.608695652 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions FoxO signaling pathway 0 -0.455533597 0 kegg kegg NA NA no no no no no no Platinum drug resistance FoxO signaling pathway 0.643478261 0.714426877 0.797425997 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism FoxO signaling pathway -0.50173913 0 0 kegg kegg NA NA no no no no no no Prevotella FoxO signaling pathway 0 0.456424852 0 acetate-producing Genus kegg 0.287 NA no no no no no no Proteasome FoxO signaling pathway 0 -0.626482213 0 kegg kegg NA NA no no no no no no Protein export FoxO signaling pathway 0 -0.722332016 0 kegg kegg NA NA no no no no no no Pyruvate metabolism FoxO signaling pathway 0 -0.475296443 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway FoxO signaling pathway 0 -0.617588933 0 kegg kegg NA NA no no no no no no Ras signaling pathway FoxO signaling pathway 0 -0.457509881 0 yes kegg kegg NA NA no up up no no no Retinol metabolism FoxO signaling pathway 0 0 0.415186615 kegg kegg NA NA no no no no no no Ribosome FoxO signaling pathway 0 -0.735177866 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes FoxO signaling pathway 0 0 0.431660232 kegg kegg NA NA no no no no no no RNA degradation FoxO signaling pathway 0 -0.445652174 0 kegg kegg NA NA no no no no no no RNA transport FoxO signaling pathway 0 -0.500988142 0 kegg kegg NA NA no no no no no no Ruminococcus FoxO signaling pathway 0 -0.573553022 0 Genus kegg 0.0679 NA no no dn no no no Ruminococcus FoxO signaling pathway -0.47826087 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Selenocompound metabolism FoxO signaling pathway 0 0.507905138 0.557014157 kegg kegg NA NA no no no no no no Spliceosome FoxO signaling pathway 0.410434783 0.558300395 0.464350064 kegg kegg NA NA no no no no no no Starch and sucrose metabolism FoxO signaling pathway 0 0.653162055 0 kegg kegg NA NA no no no no no no Steroid biosynthesis FoxO signaling pathway 0 0 0.412355212 kegg kegg NA NA no no no no no no Sulfur metabolism FoxO signaling pathway -0.450434783 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies FoxO signaling pathway 0 0 0.403861004 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism FoxO signaling pathway 0.416521739 0.690711462 0 kegg kegg NA NA no no no no no no Thiamine metabolism FoxO signaling pathway 0 -0.421936759 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis FoxO signaling pathway 0 0 0.504761905 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Fructose and mannose metabolism 0.431304348 0 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Fructose and mannose metabolism 0.769565217 -0.524703557 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Fructose and mannose metabolism 0.556521739 0 0.55032175 kegg kegg NA NA no no no no no no Holdemania Fusobacterium 0.494150797 0 0 Genus Genus 0.289 0.628 no no no no no no 2-Oxocarboxylic acid metabolism GABAergic synapse 0 -0.726284585 -0.600772201 kegg kegg NA NA no no no no up up Adherens junction GABAergic synapse -0.423478261 -0.537549407 0 kegg kegg NA NA no no no no up up Adrenergic signaling in cardiomyocytes GABAergic synapse 0 -0.46541502 0 kegg kegg NA NA no no up no up up "Alanine, aspartate and glutamate metabolism" GABAergic synapse 0.767826087 0.789525692 0.791248391 kegg kegg NA NA no no no no up up Alistipes GABAergic synapse -0.59913235 0 0 Genus kegg 0.0114 NA no up no no up up alpha-Linolenic acid metabolism GABAergic synapse 0 0.531620553 0 kegg kegg NA NA no no no no up up Aminoacyl-tRNA biosynthesis GABAergic synapse 0 -0.543478261 -0.447361647 kegg kegg NA NA no no no no up up Antifolate resistance GABAergic synapse -0.44 0 0 kegg kegg NA NA no no no no up up Apelin signaling pathway GABAergic synapse 0 -0.466403162 -0.436550837 kegg kegg NA NA no no no no up up Arginine and proline metabolism GABAergic synapse 0.615652174 0.821146245 0.63989704 kegg kegg NA NA no up no no up up Arginine biosynthesis GABAergic synapse 0.757391304 0.831027668 0.845559846 kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism GABAergic synapse 0 -0.604743083 0 kegg kegg NA NA no no no no up up Autophagy - animal GABAergic synapse 0.509565217 0.613636364 0 kegg kegg NA NA no no no no up up B cell receptor signaling pathway GABAergic synapse 0 0.46541502 0 kegg kegg NA NA no no no no up up Bifidobacterium GABAergic synapse 0 -0.419515898 0 acetate-producing Genus kegg 0.105 NA no dn no no up up Biosynthesis of amino acids GABAergic synapse 0 0.613636364 0.517631918 kegg kegg NA NA no no no no up up Biosynthesis of cofactors GABAergic synapse -0.425217391 0 0 kegg kegg NA NA no no no no up up Butanoate metabolism GABAergic synapse 0 -0.537549407 0 kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway GABAergic synapse 0 0.471343874 0 kegg kegg NA NA no no no no up up Cardiac muscle contraction GABAergic synapse 0 -0.686758893 -0.400514801 kegg kegg NA NA no no up no up up Cell cycle GABAergic synapse 0 -0.456521739 -0.494723295 kegg kegg NA NA no no no no up up cGMP-PKG signaling pathway GABAergic synapse 0.576521739 0.630434783 0 kegg kegg NA NA no no no no up up Chemokine signaling pathway GABAergic synapse 0 0.709486166 0 kegg kegg NA NA no no no no up up Cholinergic synapse GABAergic synapse 0.551304348 0.64229249 0 kegg kegg NA NA no no no no up up Circadian rhythm GABAergic synapse 0 0 -0.403088803 kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) GABAergic synapse 0 -0.586956522 0 kegg kegg NA NA no no no no up up Complement and coagulation cascades GABAergic synapse 0.425217391 0.741106719 0.457142857 kegg kegg NA NA no no no no up up Cysteine and methionine metabolism GABAergic synapse 0 -0.477272727 -0.405405405 kegg kegg NA NA no no no no up up Cytokine-cytokine receptor interaction GABAergic synapse 0 0.548418972 0 kegg kegg NA NA no no no no up up DNA replication GABAergic synapse 0 -0.583992095 -0.451480051 kegg kegg NA NA no no no no up up Drug metabolism - cytochrome P450 GABAergic synapse 0 -0.600790514 0 kegg kegg NA NA no no no no up up Drug metabolism - other enzymes GABAergic synapse 0 -0.633399209 0 kegg kegg NA NA no no no no up up EGFR tyrosine kinase inhibitor resistance GABAergic synapse 0 -0.460474308 0 kegg kegg NA NA no no no no up up Ether lipid metabolism GABAergic synapse -0.534782609 -0.501976285 -0.469498069 kegg kegg NA NA no no no no up up Fanconi anemia pathway GABAergic synapse 0 0 -0.415958816 kegg kegg NA NA no no no no up up Fatty acid biosynthesis GABAergic synapse 0.831304348 0.764822134 0.605405405 kegg kegg NA NA no no no no up up Fatty acid degradation GABAergic synapse 0.567826087 0.577075099 0 kegg kegg NA NA no no no no up up Fatty acid metabolism GABAergic synapse 0.548695652 0.646245059 0 kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway GABAergic synapse 0 0.568181818 0 kegg kegg NA NA no no no no up up Fc gamma R-mediated phagocytosis GABAergic synapse 0.499130435 0.574110672 0.64015444 kegg kegg NA NA no no no no up up Focal adhesion GABAergic synapse 0 -0.463438735 0 kegg kegg NA NA no up up no up up Folate biosynthesis GABAergic synapse 0 -0.736166008 0 kegg kegg NA NA no no no no up up FoxO signaling pathway GABAergic synapse 0.525217391 0.507905138 0 kegg kegg NA NA no no no no up up Glutamatergic synapse GABAergic synapse 0 0.650197628 0.621364221 kegg kegg NA NA no up up no up up Glycerolipid metabolism GABAergic synapse 0 0 -0.532046332 kegg kegg NA NA no no up no up up Glycerophospholipid metabolism GABAergic synapse 0 0 -0.449420849 kegg kegg NA NA no no up no up up Glycolysis / Gluconeogenesis GABAergic synapse 0 -0.46541502 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate GABAergic synapse 0.500869565 0.56027668 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin GABAergic synapse 0 -0.491106719 -0.55958816 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate GABAergic synapse 0 -0.505928854 0 kegg kegg NA NA no no no no up up Glycosphingolipid biosynthesis - ganglio series GABAergic synapse 0 -0.473320158 -0.441956242 kegg kegg NA NA no no no no up up Glyoxylate and dicarboxylate metabolism GABAergic synapse 0.663478261 0.81916996 0.794079794 kegg kegg NA NA no no no no up up Hedgehog signaling pathway GABAergic synapse 0 0 -0.507078507 kegg kegg NA NA no no no no up up HIF-1 signaling pathway GABAergic synapse 0 -0.463438735 0 kegg kegg NA NA no no no no up up Hippo signaling pathway GABAergic synapse -0.51826087 -0.672924901 0 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species GABAergic synapse 0 0.517786561 0 kegg kegg NA NA no no no no up up IL-17 signaling pathway GABAergic synapse 0.528695652 0.549407115 0.619305019 kegg kegg NA NA no no no no up up Inositol phosphate metabolism GABAergic synapse 0 0 -0.415701416 kegg kegg NA NA no no no no up up JAK-STAT signaling pathway GABAergic synapse 0 0.470355731 0 kegg kegg NA NA no no no no up up Lysine degradation GABAergic synapse 0 0 -0.599485199 kegg kegg NA NA no no no no up up Lysosome GABAergic synapse 0.436521739 0 0.40978121 kegg kegg NA NA no no no no up up Mannose type O-glycan biosynthesis GABAergic synapse 0 -0.444664032 -0.561904762 kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 GABAergic synapse 0 -0.609683794 0 kegg kegg NA NA no no no no up up Mitophagy - animal GABAergic synapse -0.419130435 0 0 kegg kegg NA NA no no no no up up mRNA surveillance pathway GABAergic synapse 0 -0.654150198 -0.553153153 kegg kegg NA NA no no no no up up mTOR signaling pathway GABAergic synapse 0 -0.450592885 0 kegg kegg NA NA no no no no up up N-Glycan biosynthesis GABAergic synapse 0 -0.716403162 -0.533590734 kegg kegg NA NA no no no no up up Neuroactive ligand-receptor interaction GABAergic synapse 0 0.441699605 0.522522523 kegg kegg NA NA up up up no up up Neutrophil extracellular trap formation GABAergic synapse 0.420869565 0.567193676 0.468468468 kegg kegg NA NA no no no no up up NF-kappa B signaling pathway GABAergic synapse 0 0.567193676 0 kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism GABAergic synapse 0.746086957 0.745059289 0.657657658 kegg kegg NA NA no no no no up up Nitrogen metabolism GABAergic synapse 0.700869565 0.897233202 0.885714286 kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway GABAergic synapse 0.691304348 0.508893281 0 kegg kegg NA NA no no no no up up One carbon pool by folate GABAergic synapse 0 -0.473320158 -0.663320463 kegg kegg NA NA no no no no up up Osteoclast differentiation GABAergic synapse 0.405217391 0.546442688 0.561132561 kegg kegg NA NA no no no no up up Other glycan degradation GABAergic synapse 0 0 -0.466924067 kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis GABAergic synapse 0 0 -0.419047619 kegg kegg NA NA no no no no up up Oxidative phosphorylation GABAergic synapse 0 -0.643280632 0 kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis GABAergic synapse 0.593043478 0.650197628 0.46975547 kegg kegg NA NA no no dn no up up Paraprevotella GABAergic synapse 0 -0.485193251 0 Genus kegg 0.118 NA no no no no up up Pentose and glucuronate interconversions GABAergic synapse 0 -0.738142292 -0.644015444 kegg kegg NA NA no no no no up up Pentose phosphate pathway GABAergic synapse 0 0.520750988 0.547232947 kegg kegg NA NA no no no no up up Peroxisome GABAergic synapse 0.673913043 0.647233202 0.514543115 kegg kegg NA NA no no no no up up Phenylalanine metabolism GABAergic synapse -0.446086957 -0.54743083 0 kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system GABAergic synapse 0 0 -0.449420849 kegg kegg NA NA no no no no up up Phospholipase D signaling pathway GABAergic synapse 0 0.556324111 0 kegg kegg NA NA no up up no up up PPAR signaling pathway GABAergic synapse 0.468695652 0.513833992 0.476190476 kegg kegg NA NA no no no no up up Propanoate metabolism GABAergic synapse 0 -0.416007905 0 kegg kegg NA NA no no no no up up Proteasome GABAergic synapse 0 -0.650197628 0 kegg kegg NA NA no no no no up up Protein export GABAergic synapse 0 -0.713438735 -0.552638353 kegg kegg NA NA no no no no up up Protein processing in endoplasmic reticulum GABAergic synapse 0 -0.657114625 0 kegg kegg NA NA no no no no up up Pyruvate metabolism GABAergic synapse 0 -0.529644269 0 kegg kegg NA NA no no no no up up Ras signaling pathway GABAergic synapse 0 -0.423913043 0 yes kegg kegg NA NA no up up no up up Renin-angiotensin system GABAergic synapse 0.513043478 0.479249012 0.571428571 kegg kegg NA NA no no no no up up Retrograde endocannabinoid signaling GABAergic synapse 0 -0.471343874 0 kegg kegg NA NA no no up no up up Ribosome GABAergic synapse -0.472173913 -0.514822134 -0.408494208 kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes GABAergic synapse 0 -0.548418972 -0.541055341 kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway GABAergic synapse 0.431304348 0.583003953 0 kegg kegg NA NA no no no no up up RNA degradation GABAergic synapse 0 -0.7756917 -0.592535393 kegg kegg NA NA no no no no up up RNA polymerase GABAergic synapse 0 -0.666996047 -0.518918919 kegg kegg NA NA no no no no up up RNA transport GABAergic synapse 0 -0.463438735 0 kegg kegg NA NA no no no no up up Ruminococcus GABAergic synapse -0.433043478 0 0 acetate-producing Genus kegg 0.335 NA no no no no up up Serotonergic synapse GABAergic synapse 0 0.47826087 0 kegg kegg NA NA no no no no up up Spliceosome GABAergic synapse 0 0 -0.401544402 kegg kegg NA NA no no no no up up Starch and sucrose metabolism GABAergic synapse 0 0.592885375 0 kegg kegg NA NA no no no no up up Synaptic vesicle cycle GABAergic synapse 0 0.555335968 0 kegg kegg NA NA no up up no up up TGF-beta signaling pathway GABAergic synapse 0 -0.526679842 0 kegg kegg NA NA no no no no up up Th1 and Th2 cell differentiation GABAergic synapse 0 0 -0.412355212 kegg kegg NA NA no no no no up up Th17 cell differentiation GABAergic synapse 0 0 -0.401801802 kegg kegg NA NA no no no no up up Thermogenesis GABAergic synapse -0.485217391 -0.650197628 -0.441956242 kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway GABAergic synapse 0 0.563241107 0 yes kegg kegg NA NA no no no no up up Ubiquinone and other terpenoid-quinone biosynthesis GABAergic synapse 0 0 -0.412355212 kegg kegg NA NA no no no no up up Ubiquitin mediated proteolysis GABAergic synapse -0.556521739 -0.467391304 0 kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" GABAergic synapse 0 -0.545454545 0 kegg kegg NA NA no no no no up up Various types of N-glycan biosynthesis GABAergic synapse 0 -0.599802372 -0.44041184 kegg kegg NA NA no no no no up up Vascular smooth muscle contraction GABAergic synapse 0 -0.462450593 0 kegg kegg NA NA no no no no up up VEGF signaling pathway GABAergic synapse 0 0.503952569 0 kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor GABAergic synapse 0 0.586956522 0 kegg kegg NA NA no no no no up up Wnt signaling pathway GABAergic synapse -0.455652174 -0.720355731 -0.516087516 kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) Galactose metabolism 0.460869565 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Galactose metabolism 0.886956522 0.583992095 0.798970399 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Galactose metabolism 0.648695652 0 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Galactose metabolism 0.582608696 0.46541502 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Gap junction 0 0 -0.498841699 kegg kegg NA NA no no no no no no ABC transporters Gap junction -0.499130435 0 -0.44967825 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes Gap junction 0.457391304 0 0 kegg kegg NA NA no no up no no no alpha-Linolenic acid metabolism Gap junction 0 0 -0.432947233 kegg kegg NA NA no no no no no no AMPK signaling pathway Gap junction 0.419130435 0 0.558558559 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Gap junction 0 0.499011858 0.423166023 kegg kegg NA NA no no no no no no Arginine and proline metabolism Gap junction -0.513043478 0 0 kegg kegg NA NA no up no no no no Ascorbate and aldarate metabolism Gap junction 0 0 -0.689317889 kegg kegg NA NA no no no no no no Autophagy - animal Gap junction -0.446956522 0 0 kegg kegg NA NA no no no no no no Autophagy - other Gap junction 0 0 -0.427799228 kegg kegg NA NA no no no no no no Basal transcription factors Gap junction 0 0 -0.502960103 kegg kegg NA NA no no no no no no beta-Alanine metabolism Gap junction 0 -0.502964427 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Gap junction 0 0 0.532561133 kegg kegg NA NA no no no no no no Butanoate metabolism Gap junction 0 -0.45256917 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Gap junction 0 0.485177866 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Gap junction 0 0.503952569 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Gap junction 0 -0.62055336 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Gap junction 0 -0.540513834 -0.60952381 kegg kegg NA NA no no no no no no Clostridium Gap junction 0 -0.562380621 0 Genus kegg 0.925 NA no no no no no no Cysteine and methionine metabolism Gap junction 0 -0.472332016 0 kegg kegg NA NA no no no no no no DNA replication Gap junction 0 0 -0.461776062 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Gap junction 0 0 -0.625225225 kegg kegg NA NA no no no no no no Endocrine resistance Gap junction 0.65826087 0.666007905 0.661518662 kegg kegg NA NA no no no no no no Ether lipid metabolism Gap junction 0 0 -0.457915058 kegg kegg NA NA no no no no no no Fanconi anemia pathway Gap junction 0 0 -0.457142857 kegg kegg NA NA no no no no no no Fatty acid degradation Gap junction -0.415652174 0 -0.484427284 kegg kegg NA NA no no no no no no Fatty acid elongation Gap junction 0 -0.545454545 0 kegg kegg NA NA no no no no no no Ferroptosis Gap junction 0.463478261 0.60770751 0 kegg kegg NA NA no no no no no no Focal adhesion Gap junction 0.41826087 0 0 kegg kegg NA NA no up up no no no Folate biosynthesis Gap junction -0.546086957 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Gap junction 0 0 -0.424453024 kegg kegg NA NA no no no no no no Galactose metabolism Gap junction 0 0 -0.578378378 kegg kegg NA NA no no no no no no Glutathione metabolism Gap junction 0 0 0.552638353 kegg kegg NA NA no no no no no no Glycerolipid metabolism Gap junction -0.457391304 0 -0.644272844 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Gap junction 0 0 -0.677477477 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Gap junction 0.509565217 0 0.558043758 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Gap junction 0 -0.54743083 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Gap junction 0 0 -0.587644788 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Gap junction 0 0 -0.684169884 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Gap junction -0.464347826 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Gap junction 0 0 -0.505791506 kegg kegg NA NA no no no no no no Hippo signaling pathway Gap junction 0.413913043 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Gap junction -0.573913043 0 -0.544916345 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Gap junction 0 0 -0.527413127 kegg kegg NA NA no no no no no no Longevity regulating pathway Gap junction 0 0.434782609 0.439124839 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Gap junction 0 -0.586956522 0 kegg kegg NA NA no no no no no no Lysine degradation Gap junction 0 0 -0.563191763 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Gap junction 0 0 -0.529214929 kegg kegg NA NA no no no no no no MAPK signaling pathway Gap junction 0 0 -0.452509653 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Gap junction 0 -0.482213439 0 kegg kegg NA NA no no no no no no Necroptosis Gap junction 0.491304348 0.533596838 0.420592021 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Gap junction -0.584347826 0 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Gap junction -0.487826087 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Gap junction 0 -0.588932806 0 kegg kegg NA NA no no no no no no Notch signaling pathway Gap junction 0 0 -0.676962677 kegg kegg NA NA no no no no no no Odoribacter Gap junction -0.422570892 -0.608719053 0 butyrate-producing Genus kegg 0.798 NA no no no no no no One carbon pool by folate Gap junction 0 0 -0.463577864 kegg kegg NA NA no no no no no no Oocyte meiosis Gap junction 0 -0.54743083 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Gap junction -0.547826087 0 0 kegg kegg NA NA no no no no no no Other glycan degradation Gap junction -0.523478261 0 -0.615958816 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Gap junction 0 0 -0.528700129 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Gap junction 0 0 -0.426254826 kegg kegg NA NA no no no no no no Peroxisome Gap junction -0.54 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Gap junction 0 0 -0.489060489 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Gap junction 0 0.552371542 0.425225225 kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism Gap junction 0.493043478 0 0.532046332 kegg kegg NA NA no no no no no no PPAR signaling pathway Gap junction -0.429565217 0 0 kegg kegg NA NA no no no no no no Prevotella Gap junction -0.411589322 0 0 Genus kegg 0.367 NA no no no no no no Primary bile acid biosynthesis Gap junction 0 -0.630434783 0 kegg kegg NA NA no no no no no no Propanoate metabolism Gap junction 0 -0.502964427 0 kegg kegg NA NA no no no no no no Proteasome Gap junction 0 -0.633399209 -0.624710425 kegg kegg NA NA no no no no no no Pyrimidine metabolism Gap junction 0 0 -0.531016731 kegg kegg NA NA no no no no no no Rap1 signaling pathway Gap junction 0.426956522 0 0.506563707 kegg kegg NA NA no no no no no no Retinol metabolism Gap junction 0 0 -0.496782497 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Gap junction 0 0 -0.502702703 kegg kegg NA NA no no no no no no RNA degradation Gap junction 0 0 -0.560617761 kegg kegg NA NA no no no no no no RNA polymerase Gap junction 0 0 -0.457657658 kegg kegg NA NA no no no no no no Selenocompound metabolism Gap junction 0 0 -0.589189189 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Gap junction -0.716521739 0 -0.461003861 kegg kegg NA NA no no no no no no Sphingolipid metabolism Gap junction 0 0 -0.455855856 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Gap junction 0 0 -0.459459459 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Gap junction 0 0 -0.534362934 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Gap junction 0 0 -0.446074646 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Gap junction 0 -0.450592885 -0.545431145 kegg kegg NA NA no no no no no no Tryptophan metabolism Gap junction 0 -0.618577075 -0.506306306 kegg kegg NA NA no up no no no no "Valine, leucine and isoleucine degradation" Gap junction 0 -0.416996047 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Gap junction 0.423478261 0 0.541827542 kegg kegg NA NA no no no no no no VEGF signaling pathway Gap junction 0 0 -0.403603604 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Gap junction 0 0 0.526126126 kegg kegg NA NA no no no no no no Wnt signaling pathway Gap junction 0 0 -0.484169884 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Gastric acid secretion 0 0.425889328 0 kegg kegg NA NA no no no no no no ABC transporters Gastric acid secretion 0 -0.54743083 0 kegg kegg NA NA no up up no no no Adherens junction Gastric acid secretion 0.916521739 0.944664032 0.903217503 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Gastric acid secretion 0 -0.543478261 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Gastric acid secretion 0 0.578063241 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Gastric acid secretion -0.414782609 -0.677865613 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Gastric acid secretion -0.469565217 -0.741106719 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Gastric acid secretion 0 0.510869565 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Gastric acid secretion 0 -0.499011858 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Gastric acid secretion 0 0.5256917 0 kegg kegg NA NA no no no no no no Apoptosis Gastric acid secretion 0 -0.415019763 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Gastric acid secretion -0.650434783 -0.575098814 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Gastric acid secretion 0 -0.652173913 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Gastric acid secretion 0 -0.669960474 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Gastric acid secretion 0 0.471343874 0 kegg kegg NA NA no no no no no no Autophagy - animal Gastric acid secretion -0.749565217 -0.901185771 -0.593307593 kegg kegg NA NA no no no no no no Autophagy - other Gastric acid secretion -0.8 -0.766798419 -0.593822394 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Gastric acid secretion 0 -0.585968379 0 kegg kegg NA NA no no no no no no Basal transcription factors Gastric acid secretion -0.573043478 0 0 kegg kegg NA NA no no no no no no Base excision repair Gastric acid secretion -0.636521739 0 0 kegg kegg NA NA no no no no no no Bifidobacterium Gastric acid secretion 0 0.419515898 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Biosynthesis of amino acids Gastric acid secretion 0 -0.419960474 0 kegg kegg NA NA no no no no no no Butanoate metabolism Gastric acid secretion 0 0.462450593 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Gastric acid secretion -0.525217391 -0.68972332 -0.462548263 kegg kegg NA NA no no no no no no Calcium signaling pathway Gastric acid secretion 0 0.574110672 0 kegg kegg NA NA no up up no no no Cardiac muscle contraction Gastric acid secretion 0 0.729249012 0.555984556 kegg kegg NA NA no no up no no no Cholinergic synapse Gastric acid secretion -0.433043478 0 0 kegg kegg NA NA no no no no no no Circadian entrainment Gastric acid secretion 0.611304348 0.790513834 0.425225225 kegg kegg NA NA no up up no no no Circadian rhythm Gastric acid secretion -0.436521739 0 -0.430888031 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Gastric acid secretion 0 0.462450593 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Gastric acid secretion 0 0 0.596138996 kegg kegg NA NA no no no no no no Dopaminergic synapse Gastric acid secretion 0 0.678853755 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Gastric acid secretion 0 0.634387352 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Gastric acid secretion 0 0.708498024 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Gastric acid secretion -0.406086957 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Gastric acid secretion 0.56173913 0.67687747 0.43963964 kegg kegg NA NA no no no no no no ErbB signaling pathway Gastric acid secretion -0.446956522 -0.587944664 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Gastric acid secretion 0 0.52173913 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Gastric acid secretion -0.415652174 -0.671936759 0 kegg kegg NA NA no no no no no no Fatty acid degradation Gastric acid secretion 0 -0.662055336 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Gastric acid secretion 0 -0.600790514 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Gastric acid secretion 0 -0.570158103 0 kegg kegg NA NA no no no no no no Focal adhesion Gastric acid secretion 0.846086957 0.889328063 0.773230373 kegg kegg NA NA no up up no no no FoxO signaling pathway Gastric acid secretion -0.48173913 -0.765810277 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Gastric acid secretion 0 -0.416996047 0 kegg kegg NA NA no no no no no no GABAergic synapse Gastric acid secretion -0.440869565 -0.546442688 0 kegg kegg NA NA no up up no no no Galactose metabolism Gastric acid secretion 0 -0.492094862 0 kegg kegg NA NA no no no no no no Gap junction Gastric acid secretion 0.588695652 0 0.470527671 kegg kegg NA NA no no no no no no Glucagon signaling pathway Gastric acid secretion 0 0.561264822 0 kegg kegg NA NA no no no no no no Glutathione metabolism Gastric acid secretion 0 0.526679842 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Gastric acid secretion 0 -0.605731225 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Gastric acid secretion -0.450434783 -0.533596838 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Gastric acid secretion 0 0.51284585 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Gastric acid secretion 0 -0.683794466 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Gastric acid secretion 0.432173913 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Gastric acid secretion -0.412173913 -0.684782609 0 kegg kegg NA NA no no no no no no GnRH secretion Gastric acid secretion 0 -0.568181818 0 kegg kegg NA NA no up up no no no Hematopoietic cell lineage Gastric acid secretion 0 0 0.428828829 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Gastric acid secretion -0.522608696 0.416996047 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Gastric acid secretion 0.90173913 0.899209486 0.813642214 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Gastric acid secretion 0 -0.57312253 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Gastric acid secretion 0 0.706521739 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Gastric acid secretion 0 -0.556324111 0 kegg kegg NA NA no no no no no no Insulin resistance Gastric acid secretion -0.66 -0.696640316 -0.532561133 kegg kegg NA NA no no no no no no Insulin signaling pathway Gastric acid secretion -0.408695652 0.43083004 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Gastric acid secretion 0 -0.767786561 0 kegg kegg NA NA no no no no no no Lachnospira Gastric acid secretion 0 0.595008667 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Leukocyte transendothelial migration Gastric acid secretion 0.689565217 0.553359684 0.613384813 kegg kegg NA NA no no no no no no Long-term depression Gastric acid secretion 0.475652174 0 0 kegg kegg NA NA no no no no no no Lysine degradation Gastric acid secretion -0.546086957 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Gastric acid secretion 0 -0.658102767 0 kegg kegg NA NA no no no no no no Melanogenesis Gastric acid secretion 0.607826087 0.723320158 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Gastric acid secretion 0 0.657114625 0 kegg kegg NA NA no no no no no no Mitophagy - animal Gastric acid secretion 0 0.451581028 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Gastric acid secretion 0 -0.656126482 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Gastric acid secretion 0 0.524703557 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Gastric acid secretion 0 -0.570158103 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Gastric acid secretion -0.633913043 -0.788537549 -0.505534106 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Gastric acid secretion 0 -0.587944664 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Gastric acid secretion 0 -0.64229249 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Gastric acid secretion 0 -0.78458498 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Gastric acid secretion 0 0.646245059 0.573745174 kegg kegg NA NA no no no no no no Oscillospira Gastric acid secretion 0 -0.453557312 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Gastric acid secretion 0 -0.612648221 0 kegg kegg NA NA no no no no no no Other glycan degradation Gastric acid secretion 0 -0.497035573 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Gastric acid secretion -0.473043478 0 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Gastric acid secretion 0.66173913 0 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Gastric acid secretion 0 0.738142292 0.588931789 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Gastric acid secretion 0.869565217 0.770750988 0.729214929 kegg kegg NA NA no no no no no no p53 signaling pathway Gastric acid secretion -0.679130435 -0.53458498 -0.406692407 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Gastric acid secretion 0 -0.585968379 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Gastric acid secretion 0 0.498023715 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Gastric acid secretion 0 0.509881423 0 kegg kegg NA NA no no no no no no Peroxisome Gastric acid secretion -0.448695652 -0.669960474 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Gastric acid secretion 0.580869565 0.625494071 0.518661519 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Gastric acid secretion 0 -0.443675889 0 kegg kegg NA NA no up up no no no Phototransduction Gastric acid secretion 0 0.595849802 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Gastric acid secretion -0.468695652 0 0 yes kegg kegg NA NA no up up no no no Platelet activation Gastric acid secretion 0.962608696 0.934782609 0.911969112 kegg kegg NA NA no no no no no no Platinum drug resistance Gastric acid secretion -0.697391304 -0.536561265 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Gastric acid secretion 0 -0.683794466 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Gastric acid secretion -0.608695652 -0.499011858 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Gastric acid secretion 0 -0.566205534 0 kegg kegg NA NA no no no no no no Proteasome Gastric acid secretion -0.480869565 0.469367589 0 kegg kegg NA NA no no no no no no Protein export Gastric acid secretion 0 0.567193676 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Gastric acid secretion 0 0.432806324 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Gastric acid secretion 0 0.533596838 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Gastric acid secretion 0 0.479249012 -0.428056628 kegg kegg NA NA no no no no no no Pyruvate metabolism Gastric acid secretion 0 0.444664032 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Gastric acid secretion 0.854782609 0.836956522 0.854568855 kegg kegg NA NA no no no no no no Ras signaling pathway Gastric acid secretion 0 0.590909091 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Gastric acid secretion 0.663478261 0.622529644 0.567824968 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Gastric acid secretion 0.409565217 0 0 kegg kegg NA NA no no no no no no Renin secretion Gastric acid secretion 0.637391304 0.809288538 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Gastric acid secretion 0 0.746047431 0 kegg kegg NA NA no no up no no no Ribosome Gastric acid secretion 0 0.583003953 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Gastric acid secretion -0.487826087 0 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Gastric acid secretion -0.680869565 -0.82312253 -0.486743887 kegg kegg NA NA no no no no no no RNA degradation Gastric acid secretion 0 0.467391304 0 kegg kegg NA NA no no no no no no RNA polymerase Gastric acid secretion -0.556521739 0 0 kegg kegg NA NA no no no no no no RNA transport Gastric acid secretion -0.474782609 0 0 kegg kegg NA NA no no no no no no Salivary secretion Gastric acid secretion 0.57826087 0.671936759 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Gastric acid secretion -0.61826087 0 0 kegg kegg NA NA no no no no no no Serotonergic synapse Gastric acid secretion 0.476521739 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Gastric acid secretion -0.436521739 -0.722332016 0 kegg kegg NA NA no no no no no no Spliceosome Gastric acid secretion -0.737391304 -0.527667984 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Gastric acid secretion 0 -0.596837945 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Gastric acid secretion 0 0.416996047 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Gastric acid secretion -0.408695652 -0.814229249 -0.48005148 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Gastric acid secretion 0 -0.543478261 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Gastric acid secretion 0 0.562252964 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Gastric acid secretion 0 -0.443675889 0 kegg kegg NA NA no no no no no no Thermogenesis Gastric acid secretion 0 0.745059289 0.557528958 kegg kegg NA NA no no no no no no Thiamine metabolism Gastric acid secretion 0 0 -0.461776062 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Gastric acid secretion 0.832173913 0.901185771 0.7997426 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Gastric acid secretion 0 0.421936759 0 kegg kegg NA NA no no no no no no Tight junction Gastric acid secretion 0.797391304 0.827075099 0.674131274 kegg kegg NA NA no no no no no no TNF signaling pathway Gastric acid secretion -0.463478261 -0.672924901 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Gastric acid secretion -0.44 -0.647233202 0 yes kegg kegg NA NA no no no no no no Type II diabetes mellitus Gastric acid secretion -0.48 -0.700592885 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Gastric acid secretion 0 0.546442688 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Gastric acid secretion 0 0.482213439 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Gastric acid secretion 0 0.429841897 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Gastric acid secretion -0.42 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Gastric acid secretion 0 0.812252964 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Gastric acid secretion 0.59826087 0.739130435 0.487001287 kegg kegg NA NA no no no no no no VEGF signaling pathway Gastric acid secretion 0 -0.421936759 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Gastric acid secretion 0 0 0.447361647 kegg kegg NA NA no no no no no no Wnt signaling pathway Gastric acid secretion 0 0.537549407 0 kegg kegg NA NA no no no no no no ABC transporters Gastric cancer 0 0.641304348 0 kegg kegg NA NA no up up no no no Acute myeloid leukemia Gastric cancer 0.410434783 0 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Gastric cancer 0.572173913 0 0.486743887 kegg kegg NA NA no no no no no no Alcoholism Gastric cancer 0 -0.433794466 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Gastric cancer 0.572173913 0.471343874 0.583011583 kegg kegg NA NA no no no no no no Alistipes Gastric cancer 0 0.420011194 0 Genus kegg 0.0114 NA no up no no no no Amino sugar and nucleotide sugar metabolism Gastric cancer -0.613043478 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Gastric cancer 0 0.461462451 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Gastric cancer -0.462608696 -0.56027668 -0.484427284 kegg kegg NA NA no no no no no no Apoptosis - multiple species Gastric cancer 0.443478261 0.59486166 0.485199485 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Gastric cancer -0.50173913 0 -0.723037323 kegg kegg NA NA no no no no no no Arginine and proline metabolism Gastric cancer -0.426086957 0 -0.400514801 kegg kegg NA NA no up no no no no Arginine biosynthesis Gastric cancer 0 0 -0.447876448 kegg kegg NA NA no no no no no no Autophagy - animal Gastric cancer 0 0 0.540540541 kegg kegg NA NA no no no no no no Autophagy - other Gastric cancer 0 0.561264822 0.78043758 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Gastric cancer 0 -0.496047431 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Gastric cancer 0.776521739 0.808300395 0.785842986 kegg kegg NA NA no no no no no no Basal transcription factors Gastric cancer 0 0 0.605405405 kegg kegg NA NA no no no no no no Base excision repair Gastric cancer 0 0.461462451 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Gastric cancer 0 -0.545454545 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Gastric cancer -0.442608696 0 -0.64041184 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Gastric cancer 0 0 -0.475160875 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Gastric cancer 0 -0.505928854 0 kegg kegg NA NA no no no no no no Breast cancer Gastric cancer 0.66 0.602766798 0.796911197 kegg kegg NA NA no no no no no no Calcium signaling pathway Gastric cancer 0.513043478 0 0.421364221 kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Gastric cancer 0.493913043 0.744071146 0.698584299 kegg kegg NA NA no no no no no no Carbon metabolism Gastric cancer -0.472173913 -0.549407115 -0.512998713 kegg kegg NA NA no no no no no no Cell cycle Gastric cancer 0 0.45256917 0.722779923 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Gastric cancer -0.751304348 -0.622529644 -0.437065637 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Gastric cancer 0 0.608695652 0 kegg kegg NA NA no no no no no no Cholesterol metabolism Gastric cancer 0 -0.472332016 0 yes kegg kegg NA NA no no up no no no Cholinergic synapse Gastric cancer 0 0 0.608751609 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Gastric cancer 0.631304348 0.445652174 0 kegg kegg NA NA no no no no no no Circadian rhythm Gastric cancer 0.52173913 0.695652174 0.815958816 kegg kegg NA NA no no no no no no Clostridium Gastric cancer 0 -0.564418232 0 Genus kegg 0.925 NA no no no no no no Collecting duct acid secretion Gastric cancer 0 -0.649209486 -0.614414414 kegg kegg NA NA no no no no no no Collinsella Gastric cancer 0 0 -0.441037645 Genus kegg 0.128 NA no no no no no no Colorectal cancer Gastric cancer 0.730434783 0.790513834 0.852767053 kegg kegg NA NA no no no no no no Complement and coagulation cascades Gastric cancer -0.409565217 0 -0.572458172 kegg kegg NA NA no no no no no no Cushing syndrome Gastric cancer 0 0.475296443 0.442213642 kegg kegg NA NA no no up no no no Drug metabolism - cytochrome P450 Gastric cancer -0.603478261 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Gastric cancer -0.511304348 0 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Gastric cancer 0.444347826 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Gastric cancer 0.426086957 0.483201581 0 kegg kegg NA NA no no no no no no Endometrial cancer Gastric cancer 0.795652174 0.59486166 0.876962677 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Gastric cancer 0 -0.482213439 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Gastric cancer 0.837391304 0.828063241 0.878764479 kegg kegg NA NA no no no no no no Fanconi anemia pathway Gastric cancer 0 0 0.4996139 kegg kegg NA NA no no no no no no Fat digestion and absorption Gastric cancer -0.444347826 0 0 yes kegg kegg NA NA no up up no no no Fatty acid elongation Gastric cancer -0.437391304 -0.539525692 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Gastric cancer 0.531304348 0 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Gastric cancer 0 0 -0.462548263 kegg kegg NA NA no no no no no no Ferroptosis Gastric cancer 0 0 -0.623166023 kegg kegg NA NA no no no no no no Focal adhesion Gastric cancer 0 -0.432806324 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Gastric cancer 0 0.492094862 0.515315315 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Gastric cancer -0.431304348 0 0 kegg kegg NA NA no no no no no no Gemmiger Gastric cancer 0 0.517309848 0 butyrate-producing Genus kegg 0.595 NA no no no no no no Glioma Gastric cancer 0.606086957 0 0.752895753 kegg kegg NA NA no no no no no no Glucagon signaling pathway Gastric cancer 0 0 0.451222651 kegg kegg NA NA no no no no no no Glutathione metabolism Gastric cancer 0 0 -0.66048906 kegg kegg NA NA no no no no no no Glycerolipid metabolism Gastric cancer 0 0.592885375 0.614671815 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Gastric cancer 0.480869565 0.475296443 0.671299871 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Gastric cancer 0 0 -0.452509653 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Gastric cancer -0.525217391 -0.46541502 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Gastric cancer 0 0.458498024 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Gastric cancer 0 0.457509881 0.428828829 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Gastric cancer 0.645217391 0.656126482 0.589189189 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Gastric cancer -0.592173913 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Gastric cancer 0.595652174 0 0.457142857 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Gastric cancer 0 0 -0.441184041 kegg kegg NA NA no no no no no no GnRH secretion Gastric cancer 0.79826087 0.805335968 0.836293436 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Gastric cancer 0.519130435 0.59486166 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Gastric cancer 0.747826087 0.590909091 0.841698842 kegg kegg NA NA no no no no no no Hepatitis B Gastric cancer 0.409565217 0 0.494465894 kegg kegg NA NA no no no no no no Hepatitis C Gastric cancer 0 0 0.43963964 kegg kegg NA NA no no no no no no Homologous recombination Gastric cancer 0 0 0.485714286 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Gastric cancer 0 -0.434782609 -0.407722008 kegg kegg NA NA no no dn no no no Human immunodeficiency virus 1 infection Gastric cancer 0 -0.447628458 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Gastric cancer -0.417391304 -0.456521739 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Gastric cancer 0 0.639328063 0.676962677 kegg kegg NA NA no no no no no no Insulin resistance Gastric cancer 0.510434783 0.457509881 0.581981982 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Gastric cancer 0 0.476284585 0 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Gastric cancer 0 0 -0.47027027 kegg kegg NA NA no no dn no no no Leukocyte transendothelial migration Gastric cancer 0 -0.431818182 0 kegg kegg NA NA no no no no no no Long-term potentiation Gastric cancer 0 0 0.600772201 kegg kegg NA NA no no up no no no Longevity regulating pathway Gastric cancer 0.513913043 0 0 kegg kegg NA NA no no no no no no Lysine degradation Gastric cancer 0.552173913 0.754940711 0.758815959 kegg kegg NA NA no no no no no no Lysosome Gastric cancer 0 -0.494071146 0 kegg kegg NA NA no no no no no no Malaria Gastric cancer 0 0 -0.501673102 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Gastric cancer 0.764347826 0.783596838 0.733075933 kegg kegg NA NA no no no no no no MAPK signaling pathway Gastric cancer 0 0 0.665379665 kegg kegg NA NA no no no no no no Melanoma Gastric cancer 0.51826087 0.464426877 0.724581725 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Gastric cancer -0.604347826 0 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Gastric cancer 0 0 0.878764479 kegg kegg NA NA no no no no no no Mineral absorption Gastric cancer 0 0 -0.526383526 kegg kegg NA NA no no no no no no mRNA surveillance pathway Gastric cancer 0.533043478 0.453557312 0.756241956 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Gastric cancer 0.480869565 0 0.618790219 kegg kegg NA NA no no no no no no Necroptosis Gastric cancer 0 0 -0.54980695 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Gastric cancer -0.479130435 -0.434782609 -0.414671815 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Gastric cancer 0.430434783 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Gastric cancer 0 0 -0.638095238 kegg kegg NA NA no no no no no no Nicotine addiction Gastric cancer 0 0.700592885 0 kegg kegg NA NA no up up no no no Nitrogen metabolism Gastric cancer 0 0 -0.402574003 kegg kegg NA NA no no no no no no Non-homologous end-joining Gastric cancer 0 -0.42687747 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Gastric cancer 0.759130435 0.812252964 0.847361647 kegg kegg NA NA no no no no no no Notch signaling pathway Gastric cancer 0.546086957 0.641304348 0.598970399 kegg kegg NA NA no no no no no no Olfactory transduction Gastric cancer 0 -0.526679842 -0.413899614 kegg kegg NA NA no no no no no no One carbon pool by folate Gastric cancer 0 0 0.420592021 kegg kegg NA NA no no no no no no Oocyte meiosis Gastric cancer 0 0 0.500643501 kegg kegg NA NA no no no no no no Other glycan degradation Gastric cancer 0 0.435770751 0.473359073 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Gastric cancer 0.466956522 0.721343874 0.768082368 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Gastric cancer 0 -0.567193676 -0.606949807 kegg kegg NA NA no no no no no no p53 signaling pathway Gastric cancer 0.523478261 0.566205534 0.526126126 kegg kegg NA NA no no no no no no Pancreatic cancer Gastric cancer 0.61826087 0.733201581 0.607722008 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Gastric cancer -0.437391304 0 -0.501415701 kegg kegg NA NA no no no no no no Pathways in cancer Gastric cancer 0.564347826 0.564229249 0.589189189 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Gastric cancer -0.493913043 0 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Gastric cancer 0 0 -0.54028314 kegg kegg NA NA no no no no no no Peroxisome Gastric cancer 0 0 -0.443500644 kegg kegg NA NA no no no no no no Pertussis Gastric cancer -0.446086957 -0.422924901 -0.47027027 kegg kegg NA NA no no dn no no no Phagosome Gastric cancer 0 0 -0.541312741 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Gastric cancer 0.670434783 0.565217391 0.828056628 kegg kegg NA NA no no no no no no Phototransduction Gastric cancer 0 -0.657114625 0 kegg kegg NA NA no no no no no no Platelet activation Gastric cancer 0 -0.425889328 0 kegg kegg NA NA no no no no no no Platinum drug resistance Gastric cancer 0.462608696 0.709486166 0.640669241 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Gastric cancer 0 0 -0.503732304 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Gastric cancer 0 -0.58201581 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Gastric cancer 0 0.695652174 0.839124839 kegg kegg NA NA no no no no no no Prostate cancer Gastric cancer 0.566086957 0 0.445559846 kegg kegg NA NA no no no no no no Protein export Gastric cancer 0 0 0.48030888 kegg kegg NA NA no no no no no no Ras signaling pathway Gastric cancer 0.413043478 0 0.636550837 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Gastric cancer -0.62173913 -0.626482213 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Gastric cancer 0.528695652 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Gastric cancer -0.492173913 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Gastric cancer 0.450434783 0 0.605662806 kegg kegg NA NA no no no no no no RNA degradation Gastric cancer 0.592173913 0 0.731274131 kegg kegg NA NA no no no no no no Ruminococcus Gastric cancer 0 -0.539377583 0 Genus kegg 0.0679 NA no no dn no no no Salmonella infection Gastric cancer -0.411304348 -0.48715415 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Gastric cancer 0 0.475296443 0.556756757 kegg kegg NA NA no no no no no no Serotonergic synapse Gastric cancer -0.426086957 0 -0.474903475 kegg kegg NA NA no no no no no no Shigellosis Gastric cancer 0 0 -0.52998713 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Gastric cancer 0.773043478 0.910079051 0.962934363 kegg kegg NA NA no no no no no no Small cell lung cancer Gastric cancer 0.609565217 0.447628458 0 kegg kegg NA NA no no up no no no Sphingolipid signaling pathway Gastric cancer 0.435652174 0 0.576576577 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Gastric cancer 0.508695652 0.660079051 0.662033462 kegg kegg NA NA no no no no no no Spliceosome Gastric cancer 0 0.688735178 0.704761905 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Gastric cancer 0 -0.432806324 -0.606692407 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Gastric cancer -0.493043478 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Gastric cancer -0.687826087 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Gastric cancer 0 0 -0.609009009 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Gastric cancer 0 -0.500988142 0 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Gastric cancer 0 0.428853755 0.598198198 kegg kegg NA NA no no no no no no Taste transduction Gastric cancer 0 0 0.692921493 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Gastric cancer 0.416521739 0.666007905 0.573745174 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Gastric cancer 0 0 0.441956242 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Gastric cancer 0 0 0.584298584 kegg kegg NA NA no no no no no no Tight junction Gastric cancer -0.420869565 -0.554347826 -0.681595882 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Gastric cancer 0 0 0.517117117 kegg kegg NA NA no no no no no no Tuberculosis Gastric cancer 0 -0.459486166 -0.44993565 kegg kegg NA NA no no dn no no no Type II diabetes mellitus Gastric cancer 0.509565217 0.640316206 0.505791506 kegg kegg NA NA no no no no no no Tyrosine metabolism Gastric cancer -0.451304348 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Gastric cancer 0.453043478 0 0.612870013 kegg kegg NA NA no no no no no no VEGF signaling pathway Gastric cancer 0.627826087 0.482213439 0.682368082 kegg kegg NA NA no no no no no no Vibrio cholerae infection Gastric cancer 0 0 -0.428056628 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Gastric cancer 0 -0.492094862 -0.552380952 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Gastric cancer 0.452173913 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Gastric cancer 0.569565217 0 0.759330759 kegg kegg NA NA no no no no no no Yersinia infection Gastric cancer 0 -0.434782609 0 kegg kegg NA NA no no no no no no 12-HEPE+blood GCA+blood 0 0 0.44665466 yes serum_ARA serum_bileacids 0.312 0.16 no no no no no no 12-ketoDCA+stool GCA+blood 0 0.747154558 0 yes stool_bileacids serum_bileacids 0.505 0.16 no no no no no no 16:0/16:0-PC+blood GCA+blood -0.733834586 0 0 yes serum_phospholipids serum_bileacids 0.00079 0.16 no up up no no no 16:0/16:0-PI+blood GCA+blood 0 0.490196078 0 yes serum_phospholipids serum_bileacids 0.358 0.16 no no no no no no 16:0/22:6-PC+blood GCA+blood -0.587969925 -0.539215686 0 yes serum_phospholipids serum_bileacids 4.53E-05 0.16 no up up no no no 16:1/16:0-PC+blood GCA+blood -0.490225564 -0.531862745 0 yes serum_phospholipids serum_bileacids 0.0215 0.16 no up up no no no 16:1/16:1-PC+blood GCA+blood -0.571428571 0 0 yes serum_phospholipids serum_bileacids 0.0177 0.16 no no up no no no 16:1/18:2-PG+blood GCA+blood -0.493233083 0 0 yes serum_phospholipids serum_bileacids 1.40E-08 0.16 no up up no no no 18:0/16:0-PC+blood GCA+blood 0 -0.482843137 0 yes serum_phospholipids serum_bileacids 9.64E-07 0.16 up up up no no no 18:0/18:1-PE+blood GCA+blood 0 0.512254902 0 yes serum_phospholipids serum_bileacids 0.00716 0.16 up up no no no no 18:0/18:2-PC+blood GCA+blood -0.457142857 0 0 yes serum_phospholipids serum_bileacids 1.74E-06 0.16 no up up no no no 18:0/22:6-PA+blood GCA+blood -0.467669173 0 -0.426324786 yes serum_phospholipids serum_bileacids 0.22 0.16 no no no no no no 18:0/22:6-PC+blood GCA+blood -0.470676692 0 0 yes serum_phospholipids serum_bileacids 0.0775 0.16 no no up no no no 18:0+blood GCA+blood 0 0 -0.524786325 yes serum_fattyacid serum_bileacids 0.344 0.16 no no no no no no 18:1/18:0-PC+blood GCA+blood -0.509774436 0 0 yes serum_phospholipids serum_bileacids 1.83E-06 0.16 no up up no no no 18:1/18:0-PS+blood GCA+blood -0.587969925 0 0 yes serum_phospholipids serum_bileacids 0.193 0.16 no no no no no no 18:1/18:2-PG+blood GCA+blood -0.472180451 0 0 yes serum_phospholipids serum_bileacids 5.58E-07 0.16 no up up no no no 18:2/16:0-PC+blood GCA+blood -0.518796992 0 0 yes serum_phospholipids serum_bileacids 8.67E-05 0.16 no up up no no no 18:3n3+blood GCA+blood -0.62406015 0 0 yes serum_fattyacid serum_bileacids 0.291 0.16 no no no no no no 20:0/20:4-PE+blood GCA+blood 0 0.558823529 0 yes serum_phospholipids serum_bileacids 0.00128 0.16 up up no no no no 20:0/20:5-PC+blood GCA+blood -0.506766917 0 0 yes serum_phospholipids serum_bileacids 0.882 0.16 no no no no no no 20:1-LPE+blood GCA+blood 0 -0.522058824 0 yes serum_phospholipids serum_bileacids 0.465 0.16 no no no no no no 20:1/20:4-PC+blood GCA+blood -0.485714286 -0.573529412 0 yes serum_phospholipids serum_bileacids 0.0419 0.16 no no up no no no 20:3/18:0-PC+blood GCA+blood -0.544360902 -0.546568627 0 yes serum_phospholipids serum_bileacids 0.296 0.16 no no no no no no 20:5/18:0-PC+blood GCA+blood -0.526315789 -0.659313725 0 yes serum_phospholipids serum_bileacids 3.97E-06 0.16 no up up no no no 22:0/16:0-PE+blood GCA+blood -0.484210526 -0.519607843 0 yes serum_phospholipids serum_bileacids 0.091 0.16 no no up no no no 22:6n3+blood GCA+blood 0 0 -0.447521368 yes serum_fattyacid serum_bileacids 0.792 0.16 no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool GCA+blood -0.571428571 0 0 yes stool_cometabolism serum_bileacids 0.33 0.16 no no no no no no AA+blood GCA+blood -0.682706767 0 0 yes serum_ARA serum_bileacids 0.212 0.16 no no no no no no Adherens junction GCA+blood 0 0 0.526153846 yes kegg serum_bileacids NA 0.16 no no no no no no Adipocytokine signaling pathway GCA+blood 0.636842105 0 0 yes kegg serum_bileacids NA 0.16 no no no no no no Aldosterone synthesis and secretion GCA+blood 0 0.523529412 0 yes kegg serum_bileacids NA 0.16 no up up no no no Allograft rejection GCA+blood 0 -0.644117647 0 yes kegg serum_bileacids NA 0.16 no no no no no no Alzheimer disease GCA+blood 0 0 0.471538462 yes kegg serum_bileacids NA 0.16 no no no no no no Amphetamine addiction GCA+blood 0 0.629411765 0 yes kegg serum_bileacids NA 0.16 no no no no no no Amyotrophic lateral sclerosis GCA+blood 0 0.535294118 0.506923077 yes kegg serum_bileacids NA 0.16 no no no no no no Arrhythmogenic right ventricular cardiomyopathy GCA+blood 0 0 0.489230769 yes kegg serum_bileacids NA 0.16 no up up no no no Autoimmune thyroid disease GCA+blood 0 -0.644117647 0 yes kegg serum_bileacids NA 0.16 no no no no no no Bacterial invasion of epithelial cells GCA+blood 0 0 0.418461538 yes kegg serum_bileacids NA 0.16 no no no no no no Biosynthesis of amino acids GCA+blood 0 -0.529411765 0 yes kegg serum_bileacids NA 0.16 no no no no no no Biosynthesis of cofactors GCA+blood 0 0 -0.417692308 yes kegg serum_bileacids NA 0.16 no no no no no no Blautia GCA+blood 0 0 0.405834292 acetate-producing yes Genus serum_bileacids 1.36E-05 0.16 up dn dn no no no Butyricimonas GCA+blood 0 0 -0.401135096 butyrate-producing yes Genus serum_bileacids 0.17 0.16 no no no no no no CA+blood GCA+blood 0 0.564071228 0 yes serum_bileacids serum_bileacids 0.606 0.16 no no no no no no Cardiac muscle contraction GCA+blood 0 0 0.497692308 yes kegg serum_bileacids NA 0.16 no no up no no no Cell adhesion molecules GCA+blood 0 -0.638235294 0 yes kegg serum_bileacids NA 0.16 no no no no no no Cellular senescence GCA+blood 0 -0.661764706 0 yes kegg serum_bileacids NA 0.16 no no no no no no d18:0-18:3-SM+blood GCA+blood -0.562406015 0 0 yes serum_phospholipids serum_bileacids 0.0879 0.16 no dn no no no no d18:1-14:1-SM+blood GCA+blood -0.497744361 0 0 yes serum_phospholipids serum_bileacids 0.0952 0.16 no dn no no no no d18:1-18:0-SM+blood GCA+blood -0.643609023 0 0 yes serum_phospholipids serum_bileacids 0.97 0.16 no no no no no no d18:1-18:1-SM+blood GCA+blood -0.596992481 0 0 yes serum_phospholipids serum_bileacids 0.916 0.16 no no no no no no d18:1-20:0-SM+blood GCA+blood -0.49924812 0 0 yes serum_phospholipids serum_bileacids 0.933 0.16 no no no no no no d18:1-20:1-SM+blood GCA+blood -0.506766917 0 0 yes serum_phospholipids serum_bileacids 0.0992 0.16 no no no no no no DHA+blood GCA+blood -0.584962406 0 0 yes serum_ARA serum_bileacids 0.872 0.16 no no no no no no Diabetic cardiomyopathy GCA+blood 0 0 0.476923077 yes kegg serum_bileacids NA 0.16 no no no no no no Endocytosis GCA+blood 0 -0.679411765 0 yes kegg serum_bileacids NA 0.16 no no no no no no EPA+blood GCA+blood -0.467669173 0 0 yes serum_ARA serum_bileacids 0.212 0.16 no no no no no no Ferroptosis GCA+blood 0.542105263 0 0 yes kegg serum_bileacids NA 0.16 no no no no no no Focal adhesion GCA+blood 0 0 0.573846154 yes kegg serum_bileacids NA 0.16 no up up no no no GnRH signaling pathway GCA+blood 0 0.535294118 0 yes kegg serum_bileacids NA 0.16 no no no no no no Graft-versus-host disease GCA+blood 0 -0.644117647 0 yes kegg serum_bileacids NA 0.16 no no no no no no Hepatocellular carcinoma GCA+blood 0 0 0.532307692 yes kegg serum_bileacids NA 0.16 no no no no no no Hippo signaling pathway GCA+blood 0 0 0.548461538 yes kegg serum_bileacids NA 0.16 no no no no no no Human papillomavirus infection GCA+blood 0 -0.714705882 0 yes kegg serum_bileacids NA 0.16 no no no no no no Huntington disease GCA+blood 0 0 0.494615385 yes kegg serum_bileacids NA 0.16 no no no no no no Hypertrophic cardiomyopathy GCA+blood 0 0 0.469230769 yes kegg serum_bileacids NA 0.16 no up up no no no Kaposi sarcoma-associated herpesvirus infection GCA+blood 0.457894737 0 -0.416923077 yes kegg serum_bileacids NA 0.16 no no dn no no no Lipid and atherosclerosis GCA+blood 0 -0.523529412 0 yes kegg serum_bileacids NA 0.16 no no no no no no Longevity regulating pathway - multiple species GCA+blood -0.463157895 0 0 yes kegg serum_bileacids NA 0.16 no no no no no no Malaria GCA+blood 0.480701754 0 0 yes kegg serum_bileacids NA 0.16 no no no no no no Mineral absorption GCA+blood 0.645614035 0 0 yes kegg serum_bileacids NA 0.16 no no no no no no Mitophagy - animal GCA+blood 0.561403509 0.535294118 0 yes kegg serum_bileacids NA 0.16 no no no no no no mTOR signaling pathway GCA+blood 0 0.520588235 0 yes kegg serum_bileacids NA 0.16 no no no no no no Natural killer cell mediated cytotoxicity GCA+blood 0 -0.644117647 0 yes kegg serum_bileacids NA 0.16 no no no no no no Necroptosis GCA+blood 0.680701754 0 0 yes kegg serum_bileacids NA 0.16 no no no no no no Oxidative phosphorylation GCA+blood 0 0 0.478461538 yes kegg serum_bileacids NA 0.16 no no no no no no Pancreatic cancer GCA+blood -0.466666667 0 0 yes kegg serum_bileacids NA 0.16 no no no no no no "Parathyroid hormone synthesis, secretion and action" GCA+blood 0 0.55 0 yes kegg serum_bileacids NA 0.16 no no no no no no Pathogenic Escherichia coli infection GCA+blood 0 -0.523529412 0 yes kegg serum_bileacids NA 0.16 no no no no no no Phagosome GCA+blood 0 -0.561764706 0 yes kegg serum_bileacids NA 0.16 no no no no no no Porphyrin and chlorophyll metabolism GCA+blood 0 0.567647059 0 yes kegg serum_bileacids NA 0.16 no no no no no no Prion disease GCA+blood 0 0 0.502307692 yes kegg serum_bileacids NA 0.16 no no no no no no Progesterone-mediated oocyte maturation GCA+blood -0.552631579 0 0 yes kegg serum_bileacids NA 0.16 no no no no no no Ras signaling pathway GCA+blood -0.563157895 0 0 yes yes kegg serum_bileacids NA 0.16 no up up no no no Retrograde endocannabinoid signaling GCA+blood 0 0 0.451538462 yes kegg serum_bileacids NA 0.16 no no up no no no RIG-I-like receptor signaling pathway GCA+blood 0 0 -0.428461538 yes kegg serum_bileacids NA 0.16 no no no no no no Salmonella infection GCA+blood 0 0 0.425384615 yes kegg serum_bileacids NA 0.16 no no no no no no Sphingolipid signaling pathway GCA+blood 0 0 0.446153846 yes kegg serum_bileacids NA 0.16 no no no no no no T cell receptor signaling pathway GCA+blood -0.463157895 0 0 yes kegg serum_bileacids NA 0.16 no no no no no no Type I diabetes mellitus GCA+blood 0 -0.644117647 0 yes kegg serum_bileacids NA 0.16 no no no no no no Ubiquitin mediated proteolysis GCA+blood 0.49122807 0.535294118 0 yes kegg serum_bileacids NA 0.16 no no no no no no Viral carcinogenesis GCA+blood 0 -0.647058824 0 yes kegg serum_bileacids NA 0.16 no no no no no no Viral myocarditis GCA+blood 0 -0.576470588 0 yes kegg serum_bileacids NA 0.16 no no no no no no Viral protein interaction with cytokine and cytokine receptor GCA+blood -0.459649123 0 0 yes kegg serum_bileacids NA 0.16 no no no no no no 12-ketoDCA+stool GCA+stool 0 -0.609458027 0 stool_bileacids stool_bileacids 0.505 0.0809 no no no no no no 5-Hydroxytryptamine+stool GCA+stool 0.624355005 0 0 stool_cometabolism stool_bileacids 0.00862 0.0809 dn dn no no no no ACA+stool GCA+stool 0 0 -0.447802141 stool_bileacids stool_bileacids 0.417 0.0809 no no no no no no Adrenergic signaling in cardiomyocytes GCA+stool 0 -0.745454545 0 kegg stool_bileacids NA 0.0809 no no up no no no Aldosterone synthesis and secretion GCA+stool 0 -0.709090909 0 kegg stool_bileacids NA 0.0809 no up up no no no Allograft rejection GCA+stool 0 0.709090909 0 kegg stool_bileacids NA 0.0809 no no no no no no Antigen processing and presentation GCA+stool 0 0.845454545 0 kegg stool_bileacids NA 0.0809 no no no no no no Apoptosis GCA+stool 0.5500516 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Asthma GCA+stool 0 0.681818182 0 kegg stool_bileacids NA 0.0809 no no no no no no Autoimmune thyroid disease GCA+stool 0 0.709090909 0 kegg stool_bileacids NA 0.0809 no no no no no no Bacterial invasion of epithelial cells GCA+stool 0.564499484 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Bacteroides GCA+stool 0 0 -0.43083004 LPS-producing Genus stool_bileacids 0.000267 0.0809 dn dn up no no no Biosynthesis of amino acids GCA+stool 0.481940144 0.627272727 0 kegg stool_bileacids NA 0.0809 no no no no no no Blautia GCA+stool 0 0.734265734 0 acetate-producing Genus stool_bileacids 1.36E-05 0.0809 up dn dn no no no CA+stool GCA+stool 0.607843137 0.776223776 0 stool_bileacids stool_bileacids 0.827 0.0809 no no no no no no Caproic acid+stool GCA+stool 0 -0.664335664 0 stool_scfa stool_bileacids 0.882 0.0809 no no no no no no Carbon metabolism GCA+stool 0 0.872727273 0 kegg stool_bileacids NA 0.0809 no no no no no no CDCA+stool GCA+stool 0.492260062 0.804195804 0 stool_bileacids stool_bileacids 0.663 0.0809 no no no no no no Cell adhesion molecules GCA+stool 0 0.727272727 0 kegg stool_bileacids NA 0.0809 no no no no no no Cellular senescence GCA+stool 0 0.618181818 0 kegg stool_bileacids NA 0.0809 no no no no no no Chemical carcinogenesis - receptor activation GCA+stool 0 -0.909090909 0 kegg stool_bileacids NA 0.0809 no no no no no no Chemokine signaling pathway GCA+stool 0.578947368 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Choline metabolism in cancer GCA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.0809 no no no no no no Clostridium GCA+stool 0 0.806183442 0 Genus stool_bileacids 0.925 0.0809 no no no no no no Cocaine addiction GCA+stool 0 -0.854545455 0 kegg stool_bileacids NA 0.0809 no no no no no no Coronavirus disease - COVID-19 GCA+stool -0.494324045 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Cortisol synthesis and secretion GCA+stool 0 -0.927272727 0 kegg stool_bileacids NA 0.0809 no no up no no no Cushing syndrome GCA+stool 0 -0.863636364 0 kegg stool_bileacids NA 0.0809 no no up no no no DCA+stool GCA+stool 0 -0.65034965 -0.499011858 stool_bileacids stool_bileacids 0.195 0.0809 no no no no no no Dopaminergic synapse GCA+stool 0 -0.636363636 0 kegg stool_bileacids NA 0.0809 no up no no no no Dorea GCA+stool 0 0.734265734 0 Genus stool_bileacids 0.00362 0.0809 up no dn no no no EGFR tyrosine kinase inhibitor resistance GCA+stool -0.504643963 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Endocrine resistance GCA+stool 0 -0.945454545 0 kegg stool_bileacids NA 0.0809 no no no no no no Endocytosis GCA+stool 0.523219814 0.736363636 0 kegg stool_bileacids NA 0.0809 no no no no no no Epithelial cell signaling in Helicobacter pylori infection GCA+stool 0.523219814 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Epstein-Barr virus infection GCA+stool 0 0.754545455 0 kegg stool_bileacids NA 0.0809 no no no no no no Gap junction GCA+stool 0 -0.8 0 kegg stool_bileacids NA 0.0809 no no no no no no Gemmiger GCA+stool 0 0 -0.560831135 butyrate-producing Genus stool_bileacids 0.595 0.0809 no no no no no no Glioma GCA+stool 0 0 0.426312818 kegg stool_bileacids NA 0.0809 no no no no no no Glutamatergic synapse GCA+stool 0 -0.790909091 0 kegg stool_bileacids NA 0.0809 no up up no no no Glycolysis / Gluconeogenesis GCA+stool 0 0.727272727 0 kegg stool_bileacids NA 0.0809 no no no no no no GnRH signaling pathway GCA+stool 0 -0.890909091 0 kegg stool_bileacids NA 0.0809 no no no no no no Graft-versus-host disease GCA+stool 0 0.709090909 0 kegg stool_bileacids NA 0.0809 no no no no no no "Growth hormone synthesis, secretion and action" GCA+stool 0 -0.909090909 0 kegg stool_bileacids NA 0.0809 no no no no no no Hematopoietic cell lineage GCA+stool -0.479876161 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Herpes simplex virus 1 infection GCA+stool 0 0.854545455 0 kegg stool_bileacids NA 0.0809 no no no no no no Human cytomegalovirus infection GCA+stool 0 0.718181818 0 kegg stool_bileacids NA 0.0809 no no dn no no no Human immunodeficiency virus 1 infection GCA+stool 0 0.754545455 0 kegg stool_bileacids NA 0.0809 no no no no no no Human papillomavirus infection GCA+stool 0.484004128 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Human T-cell leukemia virus 1 infection GCA+stool 0 0.809090909 0 kegg stool_bileacids NA 0.0809 no no no no no no Inflammatory bowel disease GCA+stool -0.564499484 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Influenza A GCA+stool 0 0 -0.507622812 kegg stool_bileacids NA 0.0809 no no no no no no Insulin secretion GCA+stool 0 -0.863636364 0 yes kegg stool_bileacids NA 0.0809 no up up no no no Intestinal immune network for IgA production GCA+stool -0.477812178 0 0 kegg stool_bileacids NA 0.0809 no no no no no no JAK-STAT signaling pathway GCA+stool 0 0 -0.459062676 kegg stool_bileacids NA 0.0809 no no no no no no Lachnospira GCA+stool 0.661506708 0 0 butyrate-producing Genus stool_bileacids 0.279 0.0809 no no no no no no Leukocyte transendothelial migration GCA+stool 0.566563467 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Lipid and atherosclerosis GCA+stool 0 0.7 0 kegg stool_bileacids NA 0.0809 no no no no no no Long-term depression GCA+stool 0 -0.627272727 0 kegg stool_bileacids NA 0.0809 no no no no no no Long-term potentiation GCA+stool 0 0 0.587803501 kegg stool_bileacids NA 0.0809 no no up no no no Longevity regulating pathway GCA+stool 0 -0.672727273 0 kegg stool_bileacids NA 0.0809 no no no no no no Longevity regulating pathway - multiple species GCA+stool 0 0.609090909 0 kegg stool_bileacids NA 0.0809 no no no no no no Morphine addiction GCA+stool 0 -0.790909091 0 kegg stool_bileacids NA 0.0809 no up up no no no mRNA surveillance pathway GCA+stool -0.477812178 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Natural killer cell mediated cytotoxicity GCA+stool 0.529411765 0.681818182 0 kegg stool_bileacids NA 0.0809 no no no no no no Neuroactive ligand-receptor interaction GCA+stool 0 0.709090909 0 kegg stool_bileacids NA 0.0809 up up up no no no Neutrophil extracellular trap formation GCA+stool 0.531475748 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Odoribacter GCA+stool 0 0.671328671 0 butyrate-producing Genus stool_bileacids 0.798 0.0809 no no no no no no p53 signaling pathway GCA+stool 0 -0.736363636 0 kegg stool_bileacids NA 0.0809 no no no no no no Pancreatic secretion GCA+stool 0 -0.627272727 0 kegg stool_bileacids NA 0.0809 no no no no no no Parabacteroides GCA+stool 0 0 -0.570158103 Genus stool_bileacids 4.19E-05 0.0809 no up up no no no Pathogenic Escherichia coli infection GCA+stool 0.496388029 0.627272727 0 kegg stool_bileacids NA 0.0809 no no no no no no Peroxisome GCA+stool 0 0.654545455 0 kegg stool_bileacids NA 0.0809 no no no no no no Pertussis GCA+stool 0 0.718181818 0 kegg stool_bileacids NA 0.0809 no no dn no no no Phagosome GCA+stool 0 0.681818182 0 kegg stool_bileacids NA 0.0809 no no no no no no Proteasome GCA+stool -0.481940144 0.7 0 kegg stool_bileacids NA 0.0809 no no no no no no Regulation of actin cytoskeleton GCA+stool 0 0.663636364 0 kegg stool_bileacids NA 0.0809 no no no no no no Regulation of lipolysis in adipocytes GCA+stool 0 -0.863636364 0 kegg stool_bileacids NA 0.0809 no no no no no no Rheumatoid arthritis GCA+stool 0 0.645454545 0 kegg stool_bileacids NA 0.0809 no no no no no no Ribosome GCA+stool -0.519091847 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Ribosome biogenesis in eukaryotes GCA+stool -0.572755418 0 0 kegg stool_bileacids NA 0.0809 no no no no no no RNA degradation GCA+stool -0.535603715 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Salmonella infection GCA+stool 0 0.863636364 0 kegg stool_bileacids NA 0.0809 no no no no no no Serotonergic synapse GCA+stool 0 -0.745454545 0 kegg stool_bileacids NA 0.0809 no no no no no no Thyroid hormone synthesis GCA+stool 0 -0.727272727 0 kegg stool_bileacids NA 0.0809 no no no no no no Tuberculosis GCA+stool 0 0.663636364 0 kegg stool_bileacids NA 0.0809 no no dn no no no Type I diabetes mellitus GCA+stool 0 0.709090909 0 kegg stool_bileacids NA 0.0809 no no no no no no Viral carcinogenesis GCA+stool 0.601651187 0 0 kegg stool_bileacids NA 0.0809 no no no no no no Viral myocarditis GCA+stool 0 0.690909091 0 kegg stool_bileacids NA 0.0809 no no no no no no Yersinia infection GCA+stool 0.537667699 0 0 kegg stool_bileacids NA 0.0809 no no no no no no 16:0/16:0-PC+blood GCDCA+blood -0.65112782 0 0 serum_phospholipids serum_bileacids 0.00079 0.31 no up up no no no 16:0/16:1-PI+blood GCDCA+blood 0.460150376 0 0 serum_phospholipids serum_bileacids 0.262 0.31 no no no no no no 16:0/18:1-PC+blood GCDCA+blood -0.515789474 0 0 serum_phospholipids serum_bileacids 6.15E-07 0.31 up up up no no no 16:0/18:2-PC+blood GCDCA+blood -0.512781955 0 0 serum_phospholipids serum_bileacids 3.24E-06 0.31 no up up no no no 16:0/20:3-PC+blood GCDCA+blood -0.463157895 0 0 serum_phospholipids serum_bileacids 5.43E-06 0.31 no up up no no no 16:0/22:6-PC+blood GCDCA+blood -0.551879699 0 0 serum_phospholipids serum_bileacids 4.53E-05 0.31 no up up no no no 16:1/16:0-PC+blood GCDCA+blood -0.622556391 0 0 serum_phospholipids serum_bileacids 0.0215 0.31 no up up no no no 16:1/16:1-PC+blood GCDCA+blood -0.678195489 0 0 serum_phospholipids serum_bileacids 0.0177 0.31 no no up no no no 16:1/18:1-PG+blood GCDCA+blood -0.502255639 0 0 serum_phospholipids serum_bileacids 3.21E-05 0.31 no up up no no no 16:1/18:2-PG+blood GCDCA+blood -0.753383459 0 0 serum_phospholipids serum_bileacids 1.40E-08 0.31 no up up no no no 18:0/16:0-PC+blood GCDCA+blood -0.523308271 0 0 serum_phospholipids serum_bileacids 9.64E-07 0.31 up up up no no no 18:0/18:0-PE+blood GCDCA+blood 0.479699248 0.509803922 0 serum_phospholipids serum_bileacids 0.00896 0.31 up up no no no no 18:0/18:1-PE+blood GCDCA+blood 0.505263158 0.583333333 0 serum_phospholipids serum_bileacids 0.00716 0.31 up up no no no no 18:0/18:2-PC+blood GCDCA+blood -0.62406015 0 0 serum_phospholipids serum_bileacids 1.74E-06 0.31 no up up no no no 18:0/20:4-PC+blood GCDCA+blood 0 -0.5 0 serum_phospholipids serum_bileacids 0.454 0.31 no no no no no no 18:0/20:4-PI+blood GCDCA+blood 0 -0.495098039 0 serum_phospholipids serum_bileacids 0.167 0.31 no no no no no no 18:0/22:6-PA+blood GCDCA+blood -0.612030075 0 -0.415384615 serum_phospholipids serum_bileacids 0.22 0.31 no no no no no no 18:0/22:6-PC+blood GCDCA+blood 0 0 -0.445470085 serum_phospholipids serum_bileacids 0.0775 0.31 no no up no no no 18:0+blood GCDCA+blood 0 0 -0.569230769 serum_fattyacid serum_bileacids 0.344 0.31 no no no no no no 18:1/16:0-PC+blood GCDCA+blood -0.547368421 0 0 serum_phospholipids serum_bileacids 2.43E-05 0.31 no up up no no no 18:1/18:0-PC+blood GCDCA+blood -0.667669173 0 0 serum_phospholipids serum_bileacids 1.83E-06 0.31 no up up no no no 18:1/18:0-PS+blood GCDCA+blood -0.741353383 0 0 serum_phospholipids serum_bileacids 0.193 0.31 no no no no no no 18:1/18:2-PG+blood GCDCA+blood -0.762406015 0 0 serum_phospholipids serum_bileacids 5.58E-07 0.31 no up up no no no 18:1/20:4-PC+blood GCDCA+blood 0 -0.600490196 0 serum_phospholipids serum_bileacids 0.582 0.31 no no no no no no 18:1/20:4-PI+blood GCDCA+blood 0 -0.524509804 0 serum_phospholipids serum_bileacids 0.192 0.31 no no no no no no 18:2-LPC+blood GCDCA+blood 0 0 0.428376068 serum_phospholipids serum_bileacids 0.00743 0.31 dn no up no no no 18:2/16:0-PC+blood GCDCA+blood -0.621052632 0 0 serum_phospholipids serum_bileacids 8.67E-05 0.31 no up up no no no 18:3n3+blood GCDCA+blood -0.584962406 0 0 serum_fattyacid serum_bileacids 0.291 0.31 no no no no no no 20:0/20:5-PC+blood GCDCA+blood -0.521804511 0 0 serum_phospholipids serum_bileacids 0.882 0.31 no no no no no no 20:1-LPA+blood GCDCA+blood -0.457142857 0 0 serum_phospholipids serum_bileacids 0.0187 0.31 dn dn no no no no 20:1-LPE+blood GCDCA+blood 0 -0.514705882 0 serum_phospholipids serum_bileacids 0.465 0.31 no no no no no no 20:1/20:4-PC+blood GCDCA+blood -0.472180451 0 -0.433846154 serum_phospholipids serum_bileacids 0.0419 0.31 no no up no no no 20:3/18:0-PC+blood GCDCA+blood -0.491729323 0 0 serum_phospholipids serum_bileacids 0.296 0.31 no no no no no no 20:4-LPE+blood GCDCA+blood 0 -0.583333333 0 serum_phospholipids serum_bileacids 0.552 0.31 no no no no no no 20:5/18:0-PC+blood GCDCA+blood -0.545864662 0 0 serum_phospholipids serum_bileacids 3.97E-06 0.31 no up up no no no 22:6n3+blood GCDCA+blood 0 0 -0.45982906 serum_fattyacid serum_bileacids 0.792 0.31 no no no no no no AA+blood GCDCA+blood -0.717293233 0 0 serum_ARA serum_bileacids 0.212 0.31 no no no no no no Adherens junction GCDCA+blood 0 0.547058824 0.599230769 kegg serum_bileacids NA 0.31 no no no no no no Adipocytokine signaling pathway GCDCA+blood 0.478947368 0 0 kegg serum_bileacids NA 0.31 no no no no no no AGE-RAGE signaling pathway in diabetic complications GCDCA+blood 0 -0.547058824 0 kegg serum_bileacids NA 0.31 no no no no no no Alzheimer disease GCDCA+blood 0 0.720588235 0.596923077 kegg serum_bileacids NA 0.31 no no no no no no Amphetamine addiction GCDCA+blood 0 0.673529412 0 kegg serum_bileacids NA 0.31 no no no no no no Amyotrophic lateral sclerosis GCDCA+blood 0 0.785294118 0.67 kegg serum_bileacids NA 0.31 no no no no no no Arginine and proline metabolism GCDCA+blood 0 -0.538235294 0 kegg serum_bileacids NA 0.31 no up no no no no Arrhythmogenic right ventricular cardiomyopathy GCDCA+blood 0 0.502941176 0.559230769 kegg serum_bileacids NA 0.31 no up up no no no Autophagy - animal GCDCA+blood 0 -0.552941176 0 kegg serum_bileacids NA 0.31 no no no no no no Bacterial invasion of epithelial cells GCDCA+blood 0 0 0.461538462 kegg serum_bileacids NA 0.31 no no no no no no Biosynthesis of amino acids GCDCA+blood 0 -0.529411765 0 kegg serum_bileacids NA 0.31 no no no no no no Biosynthesis of cofactors GCDCA+blood 0 0 -0.413846154 kegg serum_bileacids NA 0.31 no no no no no no Bladder cancer GCDCA+blood 0 -0.526470588 0 kegg serum_bileacids NA 0.31 no no no no no no Blautia GCDCA+blood 0 0 0.516298064 acetate-producing Genus serum_bileacids 1.36E-05 0.31 up dn dn no no no CA+blood GCDCA+blood 0 0.511342831 0 serum_bileacids serum_bileacids 0.606 0.31 no no no no no no Cardiac muscle contraction GCDCA+blood 0 0.661764706 0.67 kegg serum_bileacids NA 0.31 no no up no no no CDCA+blood GCDCA+blood 0.598496241 0.644607843 0 serum_bileacids serum_bileacids 0.506 0.31 no no no no no no Cell adhesion molecules GCDCA+blood 0 -0.511764706 0 kegg serum_bileacids NA 0.31 no no no no no no Cellular senescence GCDCA+blood 0 -0.564705882 0 kegg serum_bileacids NA 0.31 no no no no no no Coronavirus disease - COVID-19 GCDCA+blood 0 0.541176471 0 kegg serum_bileacids NA 0.31 no no no no no no d18:1-18:0-SM+blood GCDCA+blood -0.640601504 0 0 serum_phospholipids serum_bileacids 0.97 0.31 no no no no no no d18:1-18:1-SM+blood GCDCA+blood -0.557894737 0 0 serum_phospholipids serum_bileacids 0.916 0.31 no no no no no no d18:1-20:1-SM+blood GCDCA+blood -0.563909774 0 0 serum_phospholipids serum_bileacids 0.0992 0.31 no no no no no no Diabetic cardiomyopathy GCDCA+blood 0 0.711764706 0.645384615 kegg serum_bileacids NA 0.31 no no no no no no Dilated cardiomyopathy GCDCA+blood 0 0 0.505384615 kegg serum_bileacids NA 0.31 no up up no no no Endocytosis GCDCA+blood 0 -0.535294118 0 kegg serum_bileacids NA 0.31 no no no no no no ErbB signaling pathway GCDCA+blood 0 -0.541176471 0 kegg serum_bileacids NA 0.31 no no no no no no Fc epsilon RI signaling pathway GCDCA+blood 0 -0.514705882 0 kegg serum_bileacids NA 0.31 no no no no no no Fluid shear stress and atherosclerosis GCDCA+blood 0 0 0.403846154 kegg serum_bileacids NA 0.31 no no no no no no Focal adhesion GCDCA+blood 0 0 0.564615385 kegg serum_bileacids NA 0.31 no up up no no no FoxO signaling pathway GCDCA+blood 0 -0.547058824 0 kegg serum_bileacids NA 0.31 no no no no no no GABAergic synapse GCDCA+blood 0 -0.588235294 0 kegg serum_bileacids NA 0.31 no up up no no no Gastric acid secretion GCDCA+blood 0 0.582352941 0.526153846 kegg serum_bileacids NA 0.31 no no no no no no GCA+blood GCDCA+blood 0.831578947 0.779411765 0.764786325 yes serum_bileacids serum_bileacids 0.16 0.31 no no no no no no Hepatitis B GCDCA+blood 0 -0.567647059 0 kegg serum_bileacids NA 0.31 no no no no no no Hepatocellular carcinoma GCDCA+blood 0 0 0.64 kegg serum_bileacids NA 0.31 no no no no no no Hippo signaling pathway GCDCA+blood 0 0.558823529 0.602307692 kegg serum_bileacids NA 0.31 no no no no no no Human papillomavirus infection GCDCA+blood 0 -0.602941176 0 kegg serum_bileacids NA 0.31 no no no no no no Huntington disease GCDCA+blood 0 0.723529412 0.629230769 kegg serum_bileacids NA 0.31 no no no no no no Hypertrophic cardiomyopathy GCDCA+blood 0 0 0.538461538 kegg serum_bileacids NA 0.31 no up up no no no JAK-STAT signaling pathway GCDCA+blood 0 -0.523529412 0 kegg serum_bileacids NA 0.31 no no no no no no Kaposi sarcoma-associated herpesvirus infection GCDCA+blood 0 0 -0.413846154 kegg serum_bileacids NA 0.31 no no dn no no no Mitophagy - animal GCDCA+blood 0 0.670588235 0 kegg serum_bileacids NA 0.31 no no no no no no Natural killer cell mediated cytotoxicity GCDCA+blood 0 -0.532352941 0 kegg serum_bileacids NA 0.31 no no no no no no Nicotinate and nicotinamide metabolism GCDCA+blood 0 -0.535294118 0 kegg serum_bileacids NA 0.31 no no no no no no NOD-like receptor signaling pathway GCDCA+blood 0 -0.561764706 0 kegg serum_bileacids NA 0.31 no no no no no no Non-alcoholic fatty liver disease GCDCA+blood 0 0.658823529 0.516153846 kegg serum_bileacids NA 0.31 no no no no no no Non-small cell lung cancer GCDCA+blood 0 -0.582352941 0 kegg serum_bileacids NA 0.31 no no no no no no nutriCA+stool GCDCA+blood 0 0 0.493233083 stool_bileacids serum_bileacids 0.481 0.31 no no no no no no Oxidative phosphorylation GCDCA+blood 0 0.738235294 0.653846154 kegg serum_bileacids NA 0.31 no no no no no no Pancreatic cancer GCDCA+blood -0.477192982 0 0 kegg serum_bileacids NA 0.31 no no no no no no Parabacteroides GCDCA+blood 0 -0.5 0 Genus serum_bileacids 4.19E-05 0.31 no up up no no no Parkinson disease GCDCA+blood 0 0.714705882 0 kegg serum_bileacids NA 0.31 no no no no no no Pathways of neurodegeneration - multiple diseases GCDCA+blood 0 0.744117647 0 kegg serum_bileacids NA 0.31 no no no no no no Phenylacetic acid+stool GCDCA+blood 0 -0.618181818 0 stool_cometabolism serum_bileacids 0.785 0.31 no no no no no no Phospholipase D signaling pathway GCDCA+blood 0 -0.564705882 0 kegg serum_bileacids NA 0.31 no up up no no no Platelet activation GCDCA+blood 0 0 0.52 kegg serum_bileacids NA 0.31 no no no no no no Porphyrin and chlorophyll metabolism GCDCA+blood 0 0.573529412 0 kegg serum_bileacids NA 0.31 no no no no no no Prion disease GCDCA+blood 0 0.708823529 0.599230769 kegg serum_bileacids NA 0.31 no no no no no no Purine metabolism GCDCA+blood 0 0.588235294 -0.490769231 kegg serum_bileacids NA 0.31 no no no no no no Rap1 signaling pathway GCDCA+blood 0 0 0.554615385 kegg serum_bileacids NA 0.31 no no no no no no Ras signaling pathway GCDCA+blood -0.521052632 0 0 yes kegg serum_bileacids NA 0.31 no up up no no no Renin secretion GCDCA+blood 0 0.55 0 kegg serum_bileacids NA 0.31 no no no no no no Retrograde endocannabinoid signaling GCDCA+blood 0 0.605882353 0.577692308 kegg serum_bileacids NA 0.31 no no up no no no Ribosome GCDCA+blood 0 0.541176471 0 kegg serum_bileacids NA 0.31 no no no no no no RIG-I-like receptor signaling pathway GCDCA+blood 0 0 -0.45 kegg serum_bileacids NA 0.31 no no no no no no Roseburia GCDCA+blood 0 0.571428679 0 butyrate-producing Genus serum_bileacids 0.495 0.31 no no no no no no Shigellosis GCDCA+blood 0 0.520588235 0 kegg serum_bileacids NA 0.31 no no no no no no Thermogenesis GCDCA+blood 0 0.673529412 0.522307692 kegg serum_bileacids NA 0.31 no no no no no no Thyroid hormone signaling pathway GCDCA+blood 0 0 0.521538462 kegg serum_bileacids NA 0.31 no no no no no no Ubiquitin mediated proteolysis GCDCA+blood 0 0.708823529 0 kegg serum_bileacids NA 0.31 no no no no no no Vascular smooth muscle contraction GCDCA+blood 0 0.588235294 0 kegg serum_bileacids NA 0.31 no no no no no no Vibrio cholerae infection GCDCA+blood 0 0 0.46 kegg serum_bileacids NA 0.31 no no no no no no Viral carcinogenesis GCDCA+blood 0 -0.594117647 0 kegg serum_bileacids NA 0.31 no no no no no no 5-Hydroxytryptamine+stool GCDCA+stool 0.711042312 0 0 yes stool_cometabolism stool_bileacids 0.00862 0.0471 dn dn no no dn no Adherens junction GCDCA+stool 0.51496388 0 0 yes kegg stool_bileacids NA 0.0471 no no no no dn no Adrenergic signaling in cardiomyocytes GCDCA+stool 0 -0.609090909 0.533596838 yes kegg stool_bileacids NA 0.0471 no no up no dn no Aldosterone synthesis and secretion GCDCA+stool 0 0 0.471485037 yes kegg stool_bileacids NA 0.0471 no up up no dn no Amphetamine addiction GCDCA+stool 0 0 0.476002259 yes kegg stool_bileacids NA 0.0471 no no no no dn no Arrhythmogenic right ventricular cardiomyopathy GCDCA+stool 0.521155831 0 0 yes kegg stool_bileacids NA 0.0471 no up up no dn no Bacterial invasion of epithelial cells GCDCA+stool 0.539731682 0 0 yes kegg stool_bileacids NA 0.0471 no no no no dn no CDCA+stool GCDCA+stool 0 0.811188811 0 yes stool_bileacids stool_bileacids 0.663 0.0471 no no no no dn no Chemokine signaling pathway GCDCA+stool 0.5500516 0 0 yes kegg stool_bileacids NA 0.0471 no no no no dn no Coprococcus GCDCA+stool 0 0 -0.456521739 butyrate-producing yes Genus stool_bileacids 0.612 0.0471 no no no no dn no Dorea GCDCA+stool 0 0.622377622 0 yes Genus stool_bileacids 0.00362 0.0471 up no dn no dn no Faecalibacterium GCDCA+stool 0 0.65034965 0 butyrate-producing yes Genus stool_bileacids 0.0039 0.0471 no dn dn no dn no Focal adhesion GCDCA+stool 0.484004128 0 0 yes kegg stool_bileacids NA 0.0471 no up up no dn no GCA+stool GCDCA+stool 0.851393189 0.636363636 0.767786561 yes stool_bileacids stool_bileacids 0.0809 0.0471 no no no no dn no Glucagon signaling pathway GCDCA+stool 0 0 0.501976285 yes kegg stool_bileacids NA 0.0471 no no no no dn no Hepatocellular carcinoma GCDCA+stool 0.506707946 0 0 yes kegg stool_bileacids NA 0.0471 no no no no dn no Hypertrophic cardiomyopathy GCDCA+stool 0.473684211 0 0 yes kegg stool_bileacids NA 0.0471 no up up no dn no Intestinal immune network for IgA production GCDCA+stool 0 0.609090909 0 yes kegg stool_bileacids NA 0.0471 no no no no dn no Kaposi sarcoma-associated herpesvirus infection GCDCA+stool 0 0.618181818 0 yes kegg stool_bileacids NA 0.0471 no no dn no dn no Lachnospira GCDCA+stool 0.63880289 0 0 butyrate-producing yes Genus stool_bileacids 0.279 0.0471 no no no no dn no Leukocyte transendothelial migration GCDCA+stool 0.568627451 0 0 yes kegg stool_bileacids NA 0.0471 no no no no dn no Long-term potentiation GCDCA+stool 0 0 0.56295878 yes kegg stool_bileacids NA 0.0471 no no up no dn no mRNA surveillance pathway GCDCA+stool 0 0 0.451157538 yes kegg stool_bileacids NA 0.0471 no no no no dn no Oxytocin signaling pathway GCDCA+stool 0.484004128 0 0 yes kegg stool_bileacids NA 0.0471 no no no no dn no Proteasome GCDCA+stool -0.531475748 0 0 yes kegg stool_bileacids NA 0.0471 no no no no dn no Rap1 signaling pathway GCDCA+stool 0.519091847 0 0 yes kegg stool_bileacids NA 0.0471 no no no no dn no Ribosome biogenesis in eukaryotes GCDCA+stool -0.502579979 0 0 yes kegg stool_bileacids NA 0.0471 no no no no dn no Roseburia GCDCA+stool 0 0.847637027 0 butyrate-producing yes Genus stool_bileacids 0.495 0.0471 no no no no dn no Vibrio cholerae infection GCDCA+stool 0.498452012 0 0 yes kegg stool_bileacids NA 0.0471 no no no no dn no 11-HETE+blood GDCA+blood 0 -0.519087249 0 serum_ARA serum_bileacids 0.464 0.632 no no no no no no 12-HEPE+blood GDCA+blood 0.452339196 0 0 serum_ARA serum_bileacids 0.312 0.632 no no no no no no 12-ketoDCA+blood GDCA+blood 0.624875696 0.523615897 0.418325484 serum_bileacids serum_bileacids 0.517 0.632 no no no no no no 12-ketoDCA+stool GDCA+blood 0.681318681 0 0 stool_bileacids serum_bileacids 0.505 0.632 no no no no no no 14:0-LPC+blood GDCA+blood 0 0.553921569 0 serum_phospholipids serum_bileacids 0.00689 0.632 up up no no no no 14:0/16:0-PC+blood GDCA+blood 0.527819549 0 0 serum_phospholipids serum_bileacids 0.0358 0.632 no up no no no no 16:0/16:0-PC+blood GDCA+blood 0 -0.514705882 0 serum_phospholipids serum_bileacids 0.00079 0.632 no up up no no no 16:0/18:0-PS+blood GDCA+blood 0 -0.536764706 0 serum_phospholipids serum_bileacids 0.377 0.632 no no no no no no 16:1/18:1-PG+blood GDCA+blood 0 -0.56372549 0 serum_phospholipids serum_bileacids 3.21E-05 0.632 no up up no no no 18:0/18:0-PC+blood GDCA+blood 0 -0.651960784 0 serum_phospholipids serum_bileacids 0.426 0.632 no no no no no no 18:0/18:0-PS+blood GDCA+blood 0 -0.546568627 0 serum_phospholipids serum_bileacids 0.00617 0.632 no up no no no no 18:0/18:1-PC+blood GDCA+blood 0 -0.632352941 0 serum_phospholipids serum_bileacids 0.393 0.632 no no no no no no 18:0/18:1-PI+blood GDCA+blood 0 -0.495098039 0 serum_phospholipids serum_bileacids 0.599 0.632 no no no no no no 18:0/22:6-PA+blood GDCA+blood 0 -0.666666667 0 serum_phospholipids serum_bileacids 0.22 0.632 no no no no no no 18:0/22:6-PC+blood GDCA+blood 0 -0.50245098 0 serum_phospholipids serum_bileacids 0.0775 0.632 no no up no no no 18:0/22:6-PI+blood GDCA+blood 0 -0.544117647 0 serum_phospholipids serum_bileacids 0.425 0.632 no no no no no no 18:1/18:1-PG+blood GDCA+blood 0 -0.50245098 0 serum_phospholipids serum_bileacids 0.00352 0.632 no up up no no no 18:2/18:1-PC+blood GDCA+blood -0.563909774 0 0 serum_phospholipids serum_bileacids 2.30E-05 0.632 dn up up no no no 18:2/18:2-PC+blood GDCA+blood -0.554887218 0 0 serum_phospholipids serum_bileacids 1.98E-05 0.632 dn up up no no no 18:2n6c+blood GDCA+blood -0.464661654 0 0 serum_fattyacid serum_bileacids 0.15 0.632 no no no no no no 18:3-LPC+blood GDCA+blood -0.484210526 0 0 serum_phospholipids serum_bileacids 0.147 0.632 no no no no no no 20:1/20:4-PC+blood GDCA+blood 0 -0.571078431 0 serum_phospholipids serum_bileacids 0.0419 0.632 no no up no no no 5-HETE+blood GDCA+blood 0 -0.621313915 0 serum_ARA serum_bileacids 0.697 0.632 no no no no no no 8-HETE+blood GDCA+blood -0.533834586 0 0 serum_ARA serum_bileacids 0.741 0.632 no no no no no no Adherens junction GDCA+blood -0.473684211 0 0 kegg serum_bileacids NA 0.632 no no no no no no Adipocytokine signaling pathway GDCA+blood 0 0.517647059 0 kegg serum_bileacids NA 0.632 no no no no no no Anaerostipes GDCA+blood 0 -0.571426844 0 butyrate-producing Genus serum_bileacids 0.568 0.632 no no no no no no Apelin signaling pathway GDCA+blood 0 0 -0.437692308 kegg serum_bileacids NA 0.632 no no no no no no Asthma GDCA+blood 0 -0.635294118 0 kegg serum_bileacids NA 0.632 no no no no no no cAMP signaling pathway GDCA+blood 0 0.6 0 yes kegg serum_bileacids NA 0.632 no up up no no no CDCA+stool GDCA+blood 0 -0.745454545 0 stool_bileacids serum_bileacids 0.663 0.632 no no no no no no Clostridium GDCA+blood 0 -0.622220341 0 Genus serum_bileacids 0.925 0.632 no no no no no no Coronavirus disease - COVID-19 GDCA+blood 0 0 -0.521538462 kegg serum_bileacids NA 0.632 no no no no no no d18:1-18:1-SM+blood GDCA+blood 0 0 -0.411282051 serum_phospholipids serum_bileacids 0.916 0.632 no no no no no no d18:1-20:1-SM+blood GDCA+blood 0 0 -0.458461538 serum_phospholipids serum_bileacids 0.0992 0.632 no no no no no no DCA+stool GDCA+blood 0.752747253 0 0.45112782 stool_bileacids serum_bileacids 0.195 0.632 no no no no no no EGFR tyrosine kinase inhibitor resistance GDCA+blood 0 0 -0.413076923 kegg serum_bileacids NA 0.632 no no no no no no Endocrine resistance GDCA+blood 0 0.579411765 0 kegg serum_bileacids NA 0.632 no no no no no no Fc epsilon RI signaling pathway GDCA+blood 0 0 0.45 kegg serum_bileacids NA 0.632 no no no no no no Fluid shear stress and atherosclerosis GDCA+blood -0.456140351 0 0 kegg serum_bileacids NA 0.632 no no no no no no FoxO signaling pathway GDCA+blood 0 0 0.539230769 kegg serum_bileacids NA 0.632 no no no no no no GCA+blood GDCA+blood 0 0 0.45982906 yes serum_bileacids serum_bileacids 0.16 0.632 no no no no no no GCA+stool GDCA+blood 0 -0.636363636 0 stool_bileacids serum_bileacids 0.0809 0.632 no no no no no no GnRH signaling pathway GDCA+blood 0 0.582352941 0 kegg serum_bileacids NA 0.632 no no no no no no "Growth hormone synthesis, secretion and action" GDCA+blood 0 0.694117647 0 kegg serum_bileacids NA 0.632 no no no no no no Hematopoietic cell lineage GDCA+blood 0 -0.576470588 0 kegg serum_bileacids NA 0.632 no no no no no no Hippo signaling pathway GDCA+blood 0 -0.541176471 0 kegg serum_bileacids NA 0.632 no no no no no no Influenza A GDCA+blood -0.49122807 0 0 kegg serum_bileacids NA 0.632 no no no no no no JAK-STAT signaling pathway GDCA+blood 0 0 0.595384615 kegg serum_bileacids NA 0.632 no no no no no no Kaposi sarcoma-associated herpesvirus infection GDCA+blood 0 0 -0.427692308 kegg serum_bileacids NA 0.632 no no dn no no no L-Phenylalanine+stool GDCA+blood -0.708791209 0 0 stool_cometabolism serum_bileacids 0.398 0.632 no no no no no no L-Tryptophan+stool GDCA+blood -0.692307692 0 0 stool_cometabolism serum_bileacids 0.557 0.632 no no no no no no L-Tyrosine+stool GDCA+blood -0.725274725 0 0 stool_cometabolism serum_bileacids 0.44 0.632 no no no no no no LCA+stool GDCA+blood 0 0 0.469172932 stool_bileacids serum_bileacids 0.314 0.632 no no no no no no Leukocyte transendothelial migration GDCA+blood -0.470175439 0 0 kegg serum_bileacids NA 0.632 no no no no no no Long-term depression GDCA+blood 0 0.629411765 0 kegg serum_bileacids NA 0.632 no no no no no no Longevity regulating pathway GDCA+blood 0 0.579411765 0 kegg serum_bileacids NA 0.632 no no no no no no Longevity regulating pathway - multiple species GDCA+blood 0 -0.5 0 kegg serum_bileacids NA 0.632 no no no no no no Malaria GDCA+blood 0 0.591176471 0 kegg serum_bileacids NA 0.632 no no no no no no Mitophagy - animal GDCA+blood 0 0 -0.402307692 kegg serum_bileacids NA 0.632 no no no no no no mTOR signaling pathway GDCA+blood 0 0 -0.414615385 kegg serum_bileacids NA 0.632 no no no no no no Neuroactive ligand-receptor interaction GDCA+blood 0 0 0.403076923 kegg serum_bileacids NA 0.632 up up up no no no Pathogenic Escherichia coli infection GDCA+blood -0.49122807 0 0 kegg serum_bileacids NA 0.632 no no no no no no Prevotella GDCA+blood 0 0.563807819 0 acetate-producing Genus serum_bileacids 0.287 0.632 no no no no no no Prolactin signaling pathway GDCA+blood 0 0 0.446153846 kegg serum_bileacids NA 0.632 no no no no no no Proteasome GDCA+blood 0 -0.55 0 kegg serum_bileacids NA 0.632 no no no no no no Purine metabolism GDCA+blood 0.463157895 0 0 kegg serum_bileacids NA 0.632 no no no no no no Rap1 signaling pathway GDCA+blood -0.50877193 0 0 kegg serum_bileacids NA 0.632 no no no no no no Regulation of actin cytoskeleton GDCA+blood 0 -0.502941176 0 kegg serum_bileacids NA 0.632 no no no no no no Relaxin signaling pathway GDCA+blood 0 0.505882353 0 kegg serum_bileacids NA 0.632 no no no no no no Ribosome GDCA+blood 0 0 -0.521538462 kegg serum_bileacids NA 0.632 no no no no no no Sphingolipid signaling pathway GDCA+blood 0 0 0.507692308 kegg serum_bileacids NA 0.632 no no no no no no UDCA+stool GDCA+blood 0 -0.736363636 0 stool_bileacids serum_bileacids 0.266 0.632 no no no no no no Vascular smooth muscle contraction GDCA+blood 0 0 -0.426153846 kegg serum_bileacids NA 0.632 no no no no no no Yersinia infection GDCA+blood -0.584210526 0 0 kegg serum_bileacids NA 0.632 no no no no no no Alistipes GDCA+stool -0.494568625 0 0 Genus stool_bileacids 0.0114 0.656 no up no no no no Amphetamine addiction GDCA+stool -0.472896294 0 0 kegg stool_bileacids NA 0.656 no no no no no no Asthma GDCA+stool 0 0.678817251 0 kegg stool_bileacids NA 0.656 no no no no no no Blautia GDCA+stool 0 0.619965924 0 acetate-producing Genus stool_bileacids 1.36E-05 0.656 up dn dn no no no CA+stool GDCA+stool 0.585441482 0.812610703 0 stool_bileacids stool_bileacids 0.827 0.656 no no no no no no Carbon metabolism GDCA+stool 0 0.605924123 0 kegg stool_bileacids NA 0.656 no no no no no no CDCA+stool GDCA+stool 0 0.809108071 0 stool_bileacids stool_bileacids 0.663 0.656 no no no no no no Chemical carcinogenesis - receptor activation GDCA+stool 0 -0.651482328 0 kegg stool_bileacids NA 0.656 no no no no no no Chemokine signaling pathway GDCA+stool 0.484254066 0 0 kegg stool_bileacids NA 0.656 no no no no no no Clostridium GDCA+stool 0 0.633976454 0 Genus stool_bileacids 0.925 0.656 no no no no no no Coronavirus disease - COVID-19 GDCA+stool -0.535880299 0 0 kegg stool_bileacids NA 0.656 no no no no no no Cortisol synthesis and secretion GDCA+stool 0 -0.651482328 0 kegg stool_bileacids NA 0.656 no no up no no no DCA+stool GDCA+stool 0 0 -0.436201994 stool_bileacids stool_bileacids 0.195 0.656 no no no no no no Dorea GDCA+stool 0 0.67250541 0 Genus stool_bileacids 0.00362 0.656 up no dn no no no Epithelial cell signaling in Helicobacter pylori infection GDCA+stool 0.509034657 0 0 kegg stool_bileacids NA 0.656 no no no no no no Ferroptosis GDCA+stool -0.473928819 0 0 kegg stool_bileacids NA 0.656 no no no no no no GABAergic synapse GDCA+stool 0.517294855 0 0 kegg stool_bileacids NA 0.656 no up up no no no Gap junction GDCA+stool 0 -0.642370687 0 kegg stool_bileacids NA 0.656 no no no no no no GCA+stool GDCA+stool 0.488384164 0.65849488 0.636004268 stool_bileacids stool_bileacids 0.0809 0.656 no no no no no no GCDCA+stool GDCA+stool 0 0.711034365 0.852621584 yes stool_bileacids stool_bileacids 0.0471 0.656 no dn no no no no Glutamatergic synapse GDCA+stool 0 -0.66970561 0 kegg stool_bileacids NA 0.656 no up up no no no Glycolysis / Gluconeogenesis GDCA+stool 0 0.67426143 0 kegg stool_bileacids NA 0.656 no no no no no no "Growth hormone synthesis, secretion and action" GDCA+stool 0 -0.687928892 0 kegg stool_bileacids NA 0.656 no no no no no no Hematopoietic cell lineage GDCA+stool 0 0.651482328 0 kegg stool_bileacids NA 0.656 no no no no no no Inflammatory mediator regulation of TRP channels GDCA+stool -0.504904559 0 0 kegg stool_bileacids NA 0.656 no no no no no no Legionellosis GDCA+stool 0.525555052 0 0 kegg stool_bileacids NA 0.656 no no no no no no Lipid and atherosclerosis GDCA+stool 0.503872034 0 0 kegg stool_bileacids NA 0.656 no no no no no no Longevity regulating pathway GDCA+stool 0 -0.615035764 0 kegg stool_bileacids NA 0.656 no no no no no no Melanogenesis GDCA+stool -0.498709411 0 0 kegg stool_bileacids NA 0.656 no no no no no no Mineral absorption GDCA+stool -0.589571581 0 0 kegg stool_bileacids NA 0.656 no no no no no no Necroptosis GDCA+stool -0.549303119 0 0 kegg stool_bileacids NA 0.656 no no no no no no NOD-like receptor signaling pathway GDCA+stool 0.51626233 0 0 kegg stool_bileacids NA 0.656 no no no no no no Proteasome GDCA+stool 0 0.646926508 0 kegg stool_bileacids NA 0.656 no no no no no no Ribosome GDCA+stool -0.56066089 0 0 kegg stool_bileacids NA 0.656 no no no no no no Roseburia GDCA+stool -0.558595841 0 0 butyrate-producing Genus stool_bileacids 0.495 0.656 no no no no no no Serotonergic synapse GDCA+stool 0 -0.605924123 0 kegg stool_bileacids NA 0.656 no no no no no no Th1 and Th2 cell differentiation GDCA+stool 0 0.610479944 0 kegg stool_bileacids NA 0.656 no no no no no no Thyroid hormone synthesis GDCA+stool -0.503872034 0 0 kegg stool_bileacids NA 0.656 no no no no no no Ubiquitin mediated proteolysis GDCA+stool -0.48735164 0 0 kegg stool_bileacids NA 0.656 no no no no no no ¦Ø-MCA+stool GDCA+stool 0 0.70304991 0 stool_bileacids stool_bileacids 0.919 0.656 no no no no no no Anaerotruncus Gemmiger -0.411815359 0 0 butyrate-producing Genus Genus 0.904 0.595 no no no no no no Eggerthella Gemmiger -0.625999253 0 0 butyrate-producing Genus Genus 0.912 0.595 no no no no no no 16:0/16:0-PC+blood GGT+clinic -0.545923633 0 0 serum_phospholipids clinic 0.00079 0.00149 no up up up up no 16:0/18:0-PS+blood GGT+clinic 0 0 -0.406153846 serum_phospholipids clinic 0.377 0.00149 no no no up up no 16:0/18:2-PI+blood GGT+clinic 0 0.664285714 0 serum_phospholipids clinic 0.269 0.00149 no no no up up no 16:0/18:3-PC+blood GGT+clinic -0.581011352 0 0 serum_phospholipids clinic 0.00216 0.00149 no up up up up no 16:0/22:6-PC+blood GGT+clinic 0 -0.635714286 0 serum_phospholipids clinic 4.53E-05 0.00149 no up up up up no 18:0/18:1-PE+blood GGT+clinic 0 0.542857143 0 serum_phospholipids clinic 0.00716 0.00149 up up no up up no 18:0/20:2-PC+blood GGT+clinic 0 0 0.417692308 serum_phospholipids clinic 0.733 0.00149 no no no up up no 18:0/20:4-PC+blood GGT+clinic 0 -0.635714286 0 serum_phospholipids clinic 0.454 0.00149 no no no up up no 18:0/20:5-PC+blood GGT+clinic 0 -0.65 0 serum_phospholipids clinic 0.17 0.00149 no no no up up no 18:0/22:6-PA+blood GGT+clinic 0 -0.532142857 0 serum_phospholipids clinic 0.22 0.00149 no no no up up no 18:0/22:6-PC+blood GGT+clinic 0 -0.582142857 0 serum_phospholipids clinic 0.0775 0.00149 no no up up up no 18:1-LPC+blood GGT+clinic 0 0 0.631538462 serum_phospholipids clinic 0.179 0.00149 no no no up up no 18:1-LPE+blood GGT+clinic 0 0 0.493076923 serum_phospholipids clinic 0.117 0.00149 no no no up up no 18:1/18:1-PE+blood GGT+clinic 0 0.564285714 0 serum_phospholipids clinic 1.03E-05 0.00149 up up no up up no 18:1/18:2-PI+blood GGT+clinic 0 0 0.533846154 serum_phospholipids clinic 0.0164 0.00149 dn no up up up no 18:1/20:4-PC+blood GGT+clinic 0 -0.664285714 0 serum_phospholipids clinic 0.582 0.00149 no no no up up no 18:2-LPC+blood GGT+clinic 0 0 0.57 serum_phospholipids clinic 0.00743 0.00149 dn no up up up no 18:2/18:1-PC+blood GGT+clinic 0 0 0.405384615 serum_phospholipids clinic 2.30E-05 0.00149 dn up up up up no 18:2/18:2-PC+blood GGT+clinic 0 0 0.402307692 serum_phospholipids clinic 1.98E-05 0.00149 dn up up up up no 18:2/20:4-PC+blood GGT+clinic 0 0 0.432307692 serum_phospholipids clinic 0.0145 0.00149 no no up up up no 20:0/20:5-PC+blood GGT+clinic 0 -0.528571429 0 serum_phospholipids clinic 0.882 0.00149 no no no up up no 20:3/18:0-PC+blood GGT+clinic -0.502579979 -0.553571429 0 serum_phospholipids clinic 0.296 0.00149 no no no up up no 20:5/18:0-PC+blood GGT+clinic 0 -0.617857143 0 serum_phospholipids clinic 3.97E-06 0.00149 no up up up up no 22:6n3+blood GGT+clinic 0 -0.553571429 0 serum_fattyacid clinic 0.792 0.00149 no no no up up no Aldosterone synthesis and secretion GGT+clinic 0.436476567 0 0 kegg clinic NA 0.00149 no up up up up no Amphetamine addiction GGT+clinic 0.43083004 0 0 kegg clinic NA 0.00149 no no no up up no Anaerostipes GGT+clinic -0.483447244 0 0 butyrate-producing Genus clinic 0.568 0.00149 no no no up up no Antigen processing and presentation GGT+clinic -0.476002259 0 0 kegg clinic NA 0.00149 no no no up up no Butyric acid+stool GGT+clinic 0.523529412 0 0 yes stool_scfa clinic 0.102 0.00149 dn no no up up no Cushing syndrome GGT+clinic 0.531338227 0 0 kegg clinic NA 0.00149 no no up up up no d18:1-18:1-SM+blood GGT+clinic -0.59752322 0 0 serum_phospholipids clinic 0.916 0.00149 no no no up up no d18:1-20:0-SM+blood GGT+clinic -0.531475748 0 0 serum_phospholipids clinic 0.933 0.00149 no no no up up no d18:1-20:1-SM+blood GGT+clinic -0.477812178 0 0 serum_phospholipids clinic 0.0992 0.00149 no no no up up no DCA+stool GGT+clinic 0 0 -0.424054207 stool_bileacids clinic 0.195 0.00149 no no no up up no Dorea GGT+clinic -0.541501976 0.507201376 0 Genus clinic 0.00362 0.00149 up no dn up up no Eotaxin GGT+clinic 0.653846154 -0.501754386 0 serum_cytokines clinic 0.393 0.00149 no no no up up no EPA+blood GGT+clinic 0 -0.578571429 -0.414615385 serum_ARA clinic 0.212 0.00149 no no no up up no GCA+blood GGT+clinic 0.593395253 0 0 yes serum_bileacids clinic 0.16 0.00149 no no no up up no GCDCA+blood GGT+clinic 0 0.564285714 0 serum_bileacids clinic 0.31 0.00149 no no no up up no Glucagon signaling pathway GGT+clinic 0.452286844 0 0 kegg clinic NA 0.00149 no no no up up no HDCA+stool GGT+clinic 0.635294118 0 -0.568605308 stool_bileacids clinic 0.176 0.00149 no no no up up no Herpes simplex virus 1 infection GGT+clinic -0.496329757 0 0 kegg clinic NA 0.00149 no no no up up no Human cytomegalovirus infection GGT+clinic -0.424054207 0 0 kegg clinic NA 0.00149 no no dn up up no Human T-cell leukemia virus 1 infection GGT+clinic -0.499717674 0 0 kegg clinic NA 0.00149 no no no up up no IL-17 signaling pathway GGT+clinic -0.431959345 0 0 kegg clinic NA 0.00149 no no no up up no IL-9 GGT+clinic -0.813186813 0 0 serum_cytokines clinic 0.906 0.00149 no no no up up no Kaposi sarcoma-associated herpesvirus infection GGT+clinic 0 0.433766234 0 kegg clinic NA 0.00149 no no dn up up no L-2-Aminobutyric acid+blood GGT+clinic 0 -0.542857143 0 yes serum_aminoacids clinic 0.000328 0.00149 up up no up up no L-Alanine+blood GGT+clinic 0.578947368 0 0 yes serum_aminoacids clinic 0.00138 0.00149 up up no up up no L-Asparagine+blood GGT+clinic 0.475748194 0 0 serum_aminoacids clinic 0.784 0.00149 no no no up up no L-Glutamic acid+blood GGT+clinic 0.593395253 0 0 yes serum_aminoacids clinic 6.20E-05 0.00149 up up no up up no L-Ornithine+blood GGT+clinic 0.469556244 0 0 serum_aminoacids clinic 0.175 0.00149 no no no up up no L-Proline+blood GGT+clinic 0 0.817857143 0 yes serum_aminoacids clinic 0.00265 0.00149 up up no up up no MCP-1(MCAF) GGT+clinic 0.736263736 0 0 yes serum_cytokines clinic 0.0633 0.00149 dn no no up up no Melanogenesis GGT+clinic 0.46809712 0 0 kegg clinic NA 0.00149 no no no up up no Mineral absorption GGT+clinic 0.481648786 0 0 kegg clinic NA 0.00149 no no no up up no Mitophagy - animal GGT+clinic 0 0.448051948 0 kegg clinic NA 0.00149 no no no up up no Necroptosis GGT+clinic 0.547148504 0 0 kegg clinic NA 0.00149 no no no up up no PAI-1 GGT+clinic 0 0.447769622 0 yes DM-assocaited hormones clinic 5.10E-05 0.00149 up up up up up no Prolactin signaling pathway GGT+clinic 0 0 -0.400280112 kegg clinic NA 0.00149 no no no up up no Roseburia GGT+clinic 0 0.435470224 0 butyrate-producing Genus clinic 0.495 0.00149 no no no up up no Ruminococcus GGT+clinic -0.420064761 0.43941286 0 Genus clinic 0.0679 0.00149 no no dn up up no TCA+stool GGT+clinic 0 0.710707994 0 stool_bileacids clinic 0.458 0.00149 no no no up up no TLCA+stool GGT+clinic -0.623950099 0 0 stool_bileacids clinic 0.243 0.00149 no no no up up no TMAO+blood GGT+clinic 0 -0.557142857 0 serum_choline clinic 0.00706 0.00149 up up no up up no Transcriptional misregulation in cancer GGT+clinic -0.43083004 0 0 kegg clinic NA 0.00149 no no no up up no TXB2+blood GGT+clinic 0 -0.636275835 0 yes serum_ARA clinic 0.0644 0.00149 dn no no up up no C-peptide GIP 0 -0.633043478 0 DM-assocaited hormones DM-assocaited hormones 0.228 0.374 no no no no no no 12-ketoDCA+blood GLCA+blood 0 0.658504608 0.495473029 serum_bileacids serum_bileacids 0.517 0.319 no no no no no no "12,13-EPOME+blood" GLCA+blood 0 0 0.467574779 serum_ARA serum_bileacids 0.901 0.319 no no no no no no 14:0-LPC+blood GLCA+blood 0 0 -0.403474386 serum_phospholipids serum_bileacids 0.00689 0.319 up up no no no no 14:0/16:0-PC+blood GLCA+blood 0 0 -0.492177152 serum_phospholipids serum_bileacids 0.0358 0.319 no up no no no no 14:0/18:2-PC+blood GLCA+blood 0 0 -0.451521717 serum_phospholipids serum_bileacids 0.102 0.319 no up no no no no 14:0/20:4-PC+blood GLCA+blood 0 0 -0.407170335 serum_phospholipids serum_bileacids 0.486 0.319 no no no no no no 16:0/18:1-PC+blood GLCA+blood 0 -0.560112034 0 serum_phospholipids serum_bileacids 6.15E-07 0.319 up up up no no no 16:0/18:2-PC+blood GLCA+blood 0 -0.525105032 0 serum_phospholipids serum_bileacids 3.24E-06 0.319 no up up no no no 16:0/18:3-PC+blood GLCA+blood 0 0 -0.451521717 serum_phospholipids serum_bileacids 0.00216 0.319 no up up no no no 16:0/20:3-PC+blood GLCA+blood 0 0 -0.419490163 serum_phospholipids serum_bileacids 5.43E-06 0.319 no up up no no no 16:0+blood GLCA+blood 0 -0.555736158 -0.413330249 yes serum_fattyacid serum_bileacids 0.00876 0.319 up no no no no no 16:1-LPC+blood GLCA+blood 0 0 -0.437969906 serum_phospholipids serum_bileacids 0.0241 0.319 no up no no no no 16:1/16:0-PC+blood GLCA+blood 0 -0.485722154 0 serum_phospholipids serum_bileacids 0.0215 0.319 no up up no no no 16:1/18:2-PG+blood GLCA+blood 0 -0.525105032 0 serum_phospholipids serum_bileacids 1.40E-08 0.319 no up up no no no 16:1+blood GLCA+blood 0 -0.485722154 0 yes serum_fattyacid serum_bileacids 0.0186 0.319 no no dn no no no 18:0/16:0-PC+blood GLCA+blood 0 -0.555736158 0 serum_phospholipids serum_bileacids 9.64E-07 0.319 up up up no no no 18:0/20:3-PC+blood GLCA+blood 0 0 -0.494641117 serum_phospholipids serum_bileacids 0.0682 0.319 no up no no no no 18:1/16:0-PC+blood GLCA+blood 0 -0.560112034 0 serum_phospholipids serum_bileacids 2.43E-05 0.319 no up up no no no 18:1/18:1-PC+blood GLCA+blood 0 0 -0.467537495 serum_phospholipids serum_bileacids 1.34E-05 0.319 no up up no no no 18:1/20:4-PE+blood GLCA+blood 0 0 0.442897837 serum_phospholipids serum_bileacids 0.0578 0.319 up no no no no no 18:1/22:6-PE+blood GLCA+blood 0 -0.516353281 0 serum_phospholipids serum_bileacids 0.0047 0.319 no up no no no no 18:1+blood GLCA+blood 0 -0.516353281 0 yes serum_fattyacid serum_bileacids 0.00202 0.319 up no dn no no no 18:2/16:0-PC+blood GLCA+blood 0 -0.485722154 0 serum_phospholipids serum_bileacids 8.67E-05 0.319 no up up no no no 20:0-LPC+blood GLCA+blood 0 0.485722154 0 serum_phospholipids serum_bileacids 0.199 0.319 no no no no no no 20:1-LPE+blood GLCA+blood 0 0 -0.420722146 serum_phospholipids serum_bileacids 0.465 0.319 no no no no no no 20:2/18:0-PC+blood GLCA+blood 0 0 -0.509424912 serum_phospholipids serum_bileacids 0.0427 0.319 no up no no no no 20:2+blood GLCA+blood -0.446649911 0 0 serum_fattyacid serum_bileacids 0.478 0.319 no no no no no no 20:3-LPC+blood GLCA+blood 0 0 -0.42688206 serum_phospholipids serum_bileacids 0.0292 0.319 no up no no no no 20:3n6+blood GLCA+blood 0 0 -0.476161375 serum_fattyacid serum_bileacids 0.0884 0.319 up no no no no no 20:4-LPE+blood GLCA+blood 0.450602565 0 0 serum_phospholipids serum_bileacids 0.552 0.319 no no no no no no 22:6-LPC+blood GLCA+blood -0.517797684 0 0 serum_phospholipids serum_bileacids 0.127 0.319 no no up no no no 24:0+blood GLCA+blood 0 0 -0.414562232 serum_fattyacid serum_bileacids 0.034 0.319 dn no up no no no 5-HETE+blood GLCA+blood 0 -0.5367422 0 serum_ARA serum_bileacids 0.697 0.319 no no no no no no Akkermansia GLCA+blood -0.633494611 0 0 acetate-producing Genus serum_bileacids 0.23 0.319 no no no no no no Aldosterone synthesis and secretion GLCA+blood -0.457176242 0 0 kegg serum_bileacids NA 0.319 no up up no no no Biosynthesis of cofactors GLCA+blood 0 0 -0.439334972 kegg serum_bileacids NA 0.319 no no no no no no Blautia GLCA+blood 0 -0.525105032 0 acetate-producing Genus serum_bileacids 1.36E-05 0.319 up dn dn no no no Circadian entrainment GLCA+blood -0.516020709 0 0 kegg serum_bileacids NA 0.319 no up up no no no Colorectal cancer GLCA+blood 0 0 0.418900787 kegg serum_bileacids NA 0.319 no no no no no no Creatinine+blood GLCA+blood 0 -0.516353281 0 serum_choline serum_bileacids 0.437 0.319 no no no no no no Cystine+blood GLCA+blood 0 -0.490098029 0 yes serum_aminoacids serum_bileacids 0.00028 0.319 up up no no no no Focal adhesion GLCA+blood 0 0 0.462493715 kegg serum_bileacids NA 0.319 no up up no no no FoxO signaling pathway GLCA+blood 0 0 0.40119116 kegg serum_bileacids NA 0.319 no no no no no no Gap junction GLCA+blood -0.659737003 0 0 kegg serum_bileacids NA 0.319 no no no no no no Gemmiger GLCA+blood 0.51384503 0 0 butyrate-producing Genus serum_bileacids 0.595 0.319 no no no no no no Glutamatergic synapse GLCA+blood -0.608813907 0 0 kegg serum_bileacids NA 0.319 no up up no no no "Glycine, serine and threonine metabolism" GLCA+blood 0 0 -0.408002555 kegg serum_bileacids NA 0.319 no up no no no no GnRH signaling pathway GLCA+blood -0.521678831 0 0 kegg serum_bileacids NA 0.319 no no no no no no LCA+stool GLCA+blood 0 0 0.457488141 stool_bileacids serum_bileacids 0.314 0.319 no no no no no no Leukocyte transendothelial migration GLCA+blood 0 0 0.427074461 kegg serum_bileacids NA 0.319 no no no no no no Porphyrin and chlorophyll metabolism GLCA+blood 0 0 -0.439334972 kegg serum_bileacids NA 0.319 no no no no no no Prevotella GLCA+blood 0.684712472 0 0 Genus serum_bileacids 0.367 0.319 no no no no no no Salivary secretion GLCA+blood -0.737819084 0 0 kegg serum_bileacids NA 0.319 no no no no no no Salmonella infection GLCA+blood 0 0 0.419581927 kegg serum_bileacids NA 0.319 no no no no no no Serotonergic synapse GLCA+blood -0.504704466 0 0 kegg serum_bileacids NA 0.319 no no no no no no Sphingolipid signaling pathway GLCA+blood 0 0 0.508130061 kegg serum_bileacids NA 0.319 no no no no no no ACA+stool GLCA+stool 0 0 0.549734645 stool_bileacids stool_bileacids 0.417 0.617 no no no no no no CDCA+stool GLCA+stool 0.537137624 0 0 stool_bileacids stool_bileacids 0.663 0.617 no no no no no no DCA+stool GLCA+stool -0.644354918 0 0 stool_bileacids stool_bileacids 0.195 0.617 no no no no no no 2-Oxocarboxylic acid metabolism Glioma -0.599130435 0 0 kegg kegg NA NA no no no no no no ABC transporters Glioma -0.456521739 0 0 kegg kegg NA NA no up up no no no Adipocytokine signaling pathway Glioma 0 0 -0.429086229 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Glioma 0.570434783 0 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Glioma 0.455652174 0 0.494980695 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Glioma 0.42173913 0 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Glioma 0.756521739 0.598814229 0.558815959 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Glioma -0.653913043 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Glioma 0.482608696 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Glioma -0.69826087 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Glioma -0.44173913 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Glioma -0.414782609 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Glioma -0.476521739 -0.522727273 -0.578635779 kegg kegg NA NA no no no no no no Arginine biosynthesis Glioma 0 0 -0.404890605 kegg kegg NA NA no no no no no no Autophagy - animal Glioma 0.468695652 0.443675889 0.475160875 kegg kegg NA NA no no no no no no Autophagy - other Glioma 0.479130435 0 0.672586873 kegg kegg NA NA no no no no no no Axon guidance Glioma 0.697391304 0.493083004 0.48030888 kegg kegg NA NA no up up no no no Bacterial invasion of epithelial cells Glioma -0.500869565 0 0 kegg kegg NA NA no no no no no no Basal transcription factors Glioma 0 0 0.590990991 kegg kegg NA NA no no no no no no beta-Alanine metabolism Glioma -0.68 0 0 kegg kegg NA NA no no no no no no Bile secretion Glioma 0 -0.431818182 -0.403088803 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Glioma -0.563478261 0 -0.537709138 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Glioma -0.63826087 0 -0.437837838 kegg kegg NA NA no no no no no no Butanoate metabolism Glioma -0.631304348 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Glioma 0.5 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Glioma 0.71826087 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Glioma 0.626956522 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Glioma 0.477391304 0.463438735 0.571171171 kegg kegg NA NA no no no no no no Carbon metabolism Glioma -0.652173913 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Glioma 0.464347826 0 0 kegg kegg NA NA no no up no no no Cell cycle Glioma 0 0 0.707335907 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Glioma 0.560869565 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Glioma -0.476521739 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Glioma 0.55826087 0 0.586100386 kegg kegg NA NA no no no no no no Circadian rhythm Glioma 0.686956522 0 0.683655084 kegg kegg NA NA no no no no no no Collecting duct acid secretion Glioma 0 0 -0.466666667 kegg kegg NA NA no no no no no no Collinsella Glioma 0 0 -0.463494268 Genus kegg 0.128 NA no no no no no no Colorectal cancer Glioma 0.708695652 0 0.744401544 kegg kegg NA NA no no no no no no Complement and coagulation cascades Glioma -0.47826087 0 -0.456885457 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Glioma 0 -0.47826087 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Glioma -0.57826087 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Glioma 0 -0.447628458 0 kegg kegg NA NA no no no no no no Endometrial cancer Glioma 0.654782609 0.477272727 0.630630631 kegg kegg NA NA no no no no no no ErbB signaling pathway Glioma 0.690434783 0.460474308 0.728700129 kegg kegg NA NA no no no no no no Ether lipid metabolism Glioma 0 0 0.415444015 kegg kegg NA NA no no no no no no Fanconi anemia pathway Glioma 0 0 0.555727156 kegg kegg NA NA no no no no no no Fatty acid elongation Glioma -0.434782609 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Glioma 0.577391304 0.516798419 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Glioma 0 0.528656126 0 kegg kegg NA NA no no no no no no Ferroptosis Glioma 0 0 -0.563449163 kegg kegg NA NA no no no no no no FoxO signaling pathway Glioma 0 0 0.414414414 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Glioma -0.80173913 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Glioma -0.662608696 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Glioma 0 -0.423913043 0 kegg kegg NA NA no no no no no no Glutathione metabolism Glioma 0 -0.448616601 -0.562419562 kegg kegg NA NA no no no no no no Glycerolipid metabolism Glioma 0 0 0.427541828 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Glioma 0 0 0.60952381 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Glioma -0.472173913 0 -0.433976834 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Glioma -0.68 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Glioma 0.449565217 0 0.409009009 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Glioma 0.490434783 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Glioma 0 0 -0.43011583 kegg kegg NA NA no no no no no no GnRH secretion Glioma 0.742608696 0 0.716602317 kegg kegg NA NA no up up no no no GnRH signaling pathway Glioma 0.435652174 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Glioma 0.482608696 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Glioma 0.626086957 0 0.645817246 kegg kegg NA NA no no no no no no Hepatitis B Glioma 0.433913043 0 0 kegg kegg NA NA no no no no no no Hepatitis C Glioma 0.453043478 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Glioma -0.472173913 0 0 kegg kegg NA NA no no no no no no Homologous recombination Glioma 0 0 0.516344916 kegg kegg NA NA no no no no no no Huntington disease Glioma 0.44173913 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Glioma 0.526956522 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Glioma 0 0 0.546203346 kegg kegg NA NA no no no no no no Insulin resistance Glioma 0.453043478 0 0.411325611 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Glioma 0 0 -0.562419562 kegg kegg NA NA no no dn no no no Leishmaniasis Glioma -0.457391304 0 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Glioma -0.499130435 -0.441699605 0 kegg kegg NA NA no no no no no no Long-term potentiation Glioma 0.764347826 0 0.806949807 kegg kegg NA NA no no up no no no Lysine degradation Glioma 0 0 0.625740026 kegg kegg NA NA no no no no no no Malaria Glioma 0 0 -0.532818533 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Glioma 0.411304348 0 0.595881596 kegg kegg NA NA no no no no no no MAPK signaling pathway Glioma 0 0 0.621879022 kegg kegg NA NA no no no no no no MicroRNAs in cancer Glioma 0 0 0.78018018 kegg kegg NA NA no no no no no no Mineral absorption Glioma 0 -0.480237154 -0.509137709 kegg kegg NA NA no no no no no no Mitophagy - animal Glioma 0 0 -0.476190476 kegg kegg NA NA no no no no no no Morphine addiction Glioma 0 -0.451581028 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Glioma 0.54173913 0 0.662805663 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Glioma 0 0 0.465894466 kegg kegg NA NA no no no no no no Necroptosis Glioma 0 0 -0.522265122 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Glioma 0 0.464426877 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Glioma 0.583478261 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Glioma 0 0 -0.468725869 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Glioma 0.494782609 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Glioma -0.526956522 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Glioma 0.565217391 0 0.5997426 kegg kegg NA NA no no no no no no Oocyte meiosis Glioma 0.494782609 0 0.73976834 kegg kegg NA NA no no no no no no Osteoclast differentiation Glioma 0 0.545454545 0 kegg kegg NA NA no no no no no no Other glycan degradation Glioma -0.41826087 0 0.407207207 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Glioma 0 0 0.701158301 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Glioma 0 -0.469367589 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Glioma 0.426956522 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Glioma 0.414782609 0 0.448133848 kegg kegg NA NA no no no no no no Pancreatic cancer Glioma 0.794782609 0.631422925 0.585328185 kegg kegg NA NA no no no no no no Pancreatic secretion Glioma 0 -0.419960474 0 kegg kegg NA NA no no no no no no Paraprevotella Glioma 0 -0.428393477 0 Genus kegg 0.118 NA no no no no no no Pathogenic Escherichia coli infection Glioma -0.411304348 0 -0.488803089 kegg kegg NA NA no no no no no no Pathways in cancer Glioma 0.672173913 0 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Glioma -0.435652174 0 -0.449163449 kegg kegg NA NA no no no no no no Peroxisome Glioma 0 0 -0.403088803 kegg kegg NA NA no no no no no no Phagosome Glioma 0 0 -0.477477477 kegg kegg NA NA no no no no no no Phenylalanine metabolism Glioma -0.572173913 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Glioma 0.852173913 0 0.829343629 kegg kegg NA NA no no no no no no Phototransduction Glioma 0 0 0.42007722 kegg kegg NA NA no no no no no no Platinum drug resistance Glioma 0 0 0.523809524 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Glioma -0.539130435 -0.43083004 -0.498841699 kegg kegg NA NA no no no no no no PPAR signaling pathway Glioma 0 0.423913043 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Glioma 0.469565217 0 0.729472329 kegg kegg NA NA no no no no no no Prolactin signaling pathway Glioma 0.516521739 0 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Glioma 0 0.466403162 0 yes kegg kegg NA NA no up up no no no Protein export Glioma 0.416521739 0 0.509395109 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Glioma 0 -0.43083004 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Glioma 0 0 0.526898327 kegg kegg NA NA no no no no no no Purine metabolism Glioma 0 0 -0.486486486 kegg kegg NA NA no no no no no no Pyrimidine metabolism Glioma -0.512173913 0 0 kegg kegg NA NA no no no no no no Ras signaling pathway Glioma 0.645217391 0 0.70990991 yes kegg kegg NA NA no up up no no no Renal cell carcinoma Glioma 0.666956522 0.438735178 0.41003861 kegg kegg NA NA no no no no no no Renin-angiotensin system Glioma 0 0.484189723 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Glioma 0 0 0.598970399 kegg kegg NA NA no no no no no no RNA degradation Glioma 0.573913043 0 0.672329472 kegg kegg NA NA no no no no no no Ruminococcus Glioma 0 -0.426945341 0 Genus kegg 0.0679 NA no no dn no no no Selenocompound metabolism Glioma 0 0 0.488030888 kegg kegg NA NA no no no no no no Serotonergic synapse Glioma 0 0 -0.413642214 kegg kegg NA NA no no no no no no Shigellosis Glioma 0 0 -0.563706564 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Glioma 0.744347826 0 0.726126126 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Glioma 0.795652174 0.685770751 0.617760618 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Glioma 0.647826087 0 0.615958816 kegg kegg NA NA no no no no no no Spliceosome Glioma 0 0 0.701158301 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Glioma 0 0 -0.428571429 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Glioma -0.535652174 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Glioma -0.446086957 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Glioma -0.497391304 0 -0.518404118 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Glioma 0 0 0.433719434 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Glioma 0 0 0.471814672 kegg kegg NA NA no no no no no no Taste transduction Glioma 0 0 0.497812098 kegg kegg NA NA no no up no no no Terpenoid backbone biosynthesis Glioma 0 0 0.528442728 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Glioma 0.614782609 0 0.646846847 kegg kegg NA NA no no no no no no Thiamine metabolism Glioma -0.453913043 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Glioma 0 -0.490118577 -0.435521236 kegg kegg NA NA no no no no no no Tight junction Glioma -0.493043478 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Glioma 0.417391304 0.416007905 0.436550837 kegg kegg NA NA no no no no no no Tryptophan metabolism Glioma -0.533913043 0 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Glioma 0.543478261 0.479249012 0.445302445 kegg kegg NA NA no no no no no no Tyrosine metabolism Glioma -0.455652174 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Glioma -0.453043478 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Glioma 0 -0.464426877 -0.468983269 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Glioma -0.440869565 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Glioma 0 0 0.494208494 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Glioma 0 -0.476284585 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Glioma 0.797391304 0.424901186 0.761904762 kegg kegg NA NA no no no no no no Vibrio cholerae infection Glioma 0 -0.451581028 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Glioma 0 0 -0.432432432 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Glioma 0.540869565 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Glioma 0.510434783 0 0.728700129 kegg kegg NA NA no no no no no no Ghrelin GLP-1 0 0.408695652 0 yes DM-assocaited hormones DM-assocaited hormones 0.0108 0.256 dn no no no no no GIP GLP-1 -0.511857708 0 0 DM-assocaited hormones DM-assocaited hormones 0.374 0.256 no no no no no no Ghrelin Glucagon 0.425889328 0.509565217 0.540336134 yes DM-assocaited hormones DM-assocaited hormones 0.0108 0.0283 dn no no no no up GLP-1 Glucagon 0.657114625 0.664347826 0.770028011 DM-assocaited hormones DM-assocaited hormones 0.256 0.0283 no no no no no up Adrenergic signaling in cardiomyocytes Glucagon signaling pathway 0.697391304 0.799407115 0.872844273 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Glucagon signaling pathway -0.537391304 -0.701581028 -0.501673102 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Glucagon signaling pathway -0.606086957 -0.551383399 -0.477220077 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Glucagon signaling pathway 0 0 -0.402059202 kegg kegg NA NA no no no no no no AMPK signaling pathway Glucagon signaling pathway 0 0.631422925 0 kegg kegg NA NA no no no no no no Antifolate resistance Glucagon signaling pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Glucagon signaling pathway 0.503478261 0.656126482 0 kegg kegg NA NA no no no no no no Apoptosis Glucagon signaling pathway -0.717391304 -0.780632411 -0.711711712 kegg kegg NA NA no no no no no no Arginine and proline metabolism Glucagon signaling pathway -0.60173913 -0.808300395 -0.537194337 kegg kegg NA NA no up no no no no Arginine biosynthesis Glucagon signaling pathway -0.579130435 -0.697628458 -0.551866152 kegg kegg NA NA no no no no no no Autophagy - animal Glucagon signaling pathway 0 -0.589920949 0 kegg kegg NA NA no no no no no no Autophagy - other Glucagon signaling pathway 0 0 0.506821107 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Glucagon signaling pathway -0.526956522 -0.777667984 0 kegg kegg NA NA no no no no no no Basal transcription factors Glucagon signaling pathway 0 0.633399209 0.52020592 kegg kegg NA NA no no no no no no Base excision repair Glucagon signaling pathway 0 0.47826087 0.42985843 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Glucagon signaling pathway -0.566956522 -0.839920949 -0.727155727 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Glucagon signaling pathway 0 0.661067194 0 kegg kegg NA NA no no no no no no Butanoate metabolism Glucagon signaling pathway 0 0.447628458 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Glucagon signaling pathway 0 -0.763833992 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Glucagon signaling pathway 0.607826087 0.630434783 0.777091377 kegg kegg NA NA no up up no no no Carbon metabolism Glucagon signaling pathway -0.412173913 -0.433794466 -0.685971686 kegg kegg NA NA no no no no no no Cardiac muscle contraction Glucagon signaling pathway 0.425217391 0.740118577 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Glucagon signaling pathway 0 -0.741106719 0 kegg kegg NA NA no no no no no no Cell cycle Glucagon signaling pathway 0.536521739 0.734189723 0.657657658 kegg kegg NA NA no no no no no no Cellular senescence Glucagon signaling pathway 0 -0.672924901 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Glucagon signaling pathway 0 -0.834980237 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Glucagon signaling pathway 0 -0.669960474 0 kegg kegg NA NA no no no no no no Circadian entrainment Glucagon signaling pathway 0.680869565 0.606719368 0.418275418 kegg kegg NA NA no up up no no no Circadian rhythm Glucagon signaling pathway 0.451304348 0.649209486 0.640926641 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Glucagon signaling pathway 0 0.420948617 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Glucagon signaling pathway -0.482608696 -0.812252964 -0.593822394 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Glucagon signaling pathway 0 0.504940711 0.516344916 kegg kegg NA NA no no no no no no DNA replication Glucagon signaling pathway 0 0.644268775 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Glucagon signaling pathway 0.684347826 0.701581028 0.737709138 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Glucagon signaling pathway 0 0.554347826 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Glucagon signaling pathway 0 0.458498024 -0.500643501 kegg kegg NA NA no no no no no no ECM-receptor interaction Glucagon signaling pathway 0.431304348 0 0.47953668 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Glucagon signaling pathway 0 0.583003953 0 kegg kegg NA NA no no no no no no Endocrine resistance Glucagon signaling pathway 0.66 0.574110672 0.476705277 kegg kegg NA NA no no no no no no Endocytosis Glucagon signaling pathway 0 -0.739130435 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Glucagon signaling pathway 0.586086957 0.648221344 0.433204633 kegg kegg NA NA no no no no no no Ether lipid metabolism Glucagon signaling pathway 0 0.624505929 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Glucagon signaling pathway 0 0.473320158 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Glucagon signaling pathway -0.454782609 -0.734189723 -0.421106821 kegg kegg NA NA no no no no no no Fatty acid degradation Glucagon signaling pathway -0.433913043 -0.614624506 -0.495495495 kegg kegg NA NA no no no no no no Fatty acid metabolism Glucagon signaling pathway -0.509565217 -0.645256917 -0.473101673 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Glucagon signaling pathway 0 -0.802371542 -0.531788932 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Glucagon signaling pathway -0.564347826 -0.845849802 -0.604375804 kegg kegg NA NA no no no no no no Folate biosynthesis Glucagon signaling pathway 0 0.416996047 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Glucagon signaling pathway -0.5 0 -0.677477477 kegg kegg NA NA no no no no no no GABAergic synapse Glucagon signaling pathway 0 -0.544466403 0 kegg kegg NA NA no up up no no no Galactose metabolism Glucagon signaling pathway -0.624347826 -0.586956522 -0.496782497 kegg kegg NA NA no no no no no no Gap junction Glucagon signaling pathway 0.550434783 0 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Glucagon signaling pathway 0.415652174 0 0 kegg kegg NA NA no up up no no no Glutathione metabolism Glucagon signaling pathway 0 0.68083004 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Glucagon signaling pathway -0.466956522 0 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Glucagon signaling pathway 0 0.595849802 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Glucagon signaling pathway -0.54173913 -0.568181818 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Glucagon signaling pathway -0.530434783 -0.66798419 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Glucagon signaling pathway 0 0.472332016 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Glucagon signaling pathway -0.668695652 -0.730237154 -0.606177606 kegg kegg NA NA no no no no no no GnRH signaling pathway Glucagon signaling pathway 0.744347826 0.747035573 0.73024453 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Glucagon signaling pathway 0.446086957 0.504940711 0.428571429 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Glucagon signaling pathway 0 0.445652174 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Glucagon signaling pathway 0 0.448616601 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Glucagon signaling pathway -0.539130435 -0.646245059 0 kegg kegg NA NA no no no no no no Histidine metabolism Glucagon signaling pathway -0.406956522 0 -0.523809524 kegg kegg NA NA no no no no no no Homologous recombination Glucagon signaling pathway 0 0 0.430630631 kegg kegg NA NA no no no no no no IL-17 signaling pathway Glucagon signaling pathway -0.565217391 -0.806324111 -0.631660232 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Glucagon signaling pathway 0.811304348 0.889328063 0.823680824 kegg kegg NA NA no no no no no no Insulin secretion Glucagon signaling pathway 0.614782609 0.745059289 0.653539254 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Glucagon signaling pathway 0.42173913 0.605731225 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Glucagon signaling pathway 0 -0.435770751 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Glucagon signaling pathway 0 0 -0.407464607 kegg kegg NA NA no no no no no no Long-term depression Glucagon signaling pathway 0.526956522 0 0.404375804 kegg kegg NA NA no no no no no no Long-term potentiation Glucagon signaling pathway 0.616521739 0 0.542084942 kegg kegg NA NA no no up no no no Lysine degradation Glucagon signaling pathway 0 0 0.428314028 kegg kegg NA NA no no no no no no Lysosome Glucagon signaling pathway -0.64 -0.789525692 -0.777606178 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Glucagon signaling pathway 0 0 0.437323037 kegg kegg NA NA no no no no no no Melanogenesis Glucagon signaling pathway 0.773043478 0.907114625 0.843500644 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Glucagon signaling pathway 0 0.461462451 0 kegg kegg NA NA no no no no no no Mismatch repair Glucagon signaling pathway 0 0.530632411 0 kegg kegg NA NA no no no no no no Mitophagy - animal Glucagon signaling pathway 0.486086957 0.700592885 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Glucagon signaling pathway 0.426086957 0.751976285 0.736936937 kegg kegg NA NA no no no no no no mTOR signaling pathway Glucagon signaling pathway 0 0.56027668 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Glucagon signaling pathway 0.555652174 0.70256917 0.497039897 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Glucagon signaling pathway -0.412173913 -0.683794466 0 kegg kegg NA NA no no no no no no Necroptosis Glucagon signaling pathway 0.495652174 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Glucagon signaling pathway -0.411304348 -0.804347826 -0.657142857 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Glucagon signaling pathway 0 -0.583003953 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Glucagon signaling pathway -0.685217391 -0.791501976 -0.698584299 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Glucagon signaling pathway -0.54 -0.659090909 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Glucagon signaling pathway -0.565217391 -0.751976285 -0.594851995 kegg kegg NA NA no no no no no no Nitrogen metabolism Glucagon signaling pathway -0.514782609 -0.62055336 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Glucagon signaling pathway -0.614782609 -0.787549407 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Glucagon signaling pathway 0 0.645256917 0 kegg kegg NA NA no no no no no no Olfactory transduction Glucagon signaling pathway 0 -0.707509881 -0.623423423 kegg kegg NA NA no no no no no no One carbon pool by folate Glucagon signaling pathway 0 0.670948617 0 kegg kegg NA NA no no no no no no Oocyte meiosis Glucagon signaling pathway 0.533043478 0 0.614671815 kegg kegg NA NA no no no no no no Osteoclast differentiation Glucagon signaling pathway -0.78173913 -0.881422925 -0.602316602 kegg kegg NA NA no no no no no no Other glycan degradation Glucagon signaling pathway -0.574782609 0 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Glucagon signaling pathway 0 0.427865613 0.445045045 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Glucagon signaling pathway 0.594782609 0.558300395 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Glucagon signaling pathway 0.406956522 0.738142292 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Glucagon signaling pathway -0.454782609 -0.760869565 -0.634749035 kegg kegg NA NA no no dn no no no Parabacteroides Glucagon signaling pathway 0 0 -0.411995625 Genus kegg 4.19E-05 NA no up up no no no Pentose and glucuronate interconversions Glucagon signaling pathway 0 0.575098814 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Glucagon signaling pathway -0.695652174 -0.851778656 -0.779407979 kegg kegg NA NA no no no no no no Peroxisome Glucagon signaling pathway -0.490434783 -0.736166008 -0.448391248 kegg kegg NA NA no no no no no no Phagosome Glucagon signaling pathway -0.500869565 -0.774703557 -0.581209781 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Glucagon signaling pathway 0.505217391 0.419960474 0.489060489 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Glucagon signaling pathway 0 -0.436758893 0 kegg kegg NA NA no up up no no no Phototransduction Glucagon signaling pathway 0.510434783 0 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Glucagon signaling pathway 0 0 0.432175032 yes kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism Glucagon signaling pathway 0 0.522727273 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Glucagon signaling pathway -0.425217391 -0.816205534 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Glucagon signaling pathway 0 -0.643280632 0 kegg kegg NA NA no no no no no no Propanoate metabolism Glucagon signaling pathway 0 0.444664032 0.413899614 kegg kegg NA NA no no no no no no Protein export Glucagon signaling pathway 0.57826087 0.597826087 0.572200772 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Glucagon signaling pathway 0.669565217 0.732213439 0.404118404 kegg kegg NA NA no no no no no no Purine metabolism Glucagon signaling pathway 0 0.628458498 0 kegg kegg NA NA no no no no no no Pyramidobacter Glucagon signaling pathway 0 0 0.403624964 Genus kegg 0.45 NA no no no no no no Pyrimidine metabolism Glucagon signaling pathway 0 0.572134387 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Glucagon signaling pathway 0 0.602766798 0 kegg kegg NA NA no no no no no no Ras signaling pathway Glucagon signaling pathway 0 0.508893281 0.438610039 yes kegg kegg NA NA no up up no no no Renin-angiotensin system Glucagon signaling pathway 0 -0.825098814 -0.543114543 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Glucagon signaling pathway 0 0.679841897 0 kegg kegg NA NA no no up no no no Ribosome Glucagon signaling pathway 0.536521739 0.685770751 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Glucagon signaling pathway 0.470434783 0.70256917 0.541827542 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Glucagon signaling pathway 0 -0.664031621 0 kegg kegg NA NA no no no no no no RNA degradation Glucagon signaling pathway 0.411304348 0.751976285 0.580694981 kegg kegg NA NA no no no no no no RNA polymerase Glucagon signaling pathway 0.48173913 0.824110672 0 kegg kegg NA NA no no no no no no RNA transport Glucagon signaling pathway 0 0.449604743 0.524581725 kegg kegg NA NA no no no no no no Sarcina Glucagon signaling pathway 0 -0.444554224 0 Genus kegg 0.0703 NA no no no no no no Serotonergic synapse Glucagon signaling pathway 0.41826087 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Glucagon signaling pathway 0 0 0.461776062 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Glucagon signaling pathway 0 -0.502964427 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Glucagon signaling pathway -0.533043478 0 -0.516344916 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Glucagon signaling pathway 0 -0.625494071 0 kegg kegg NA NA no no no no no no Spliceosome Glucagon signaling pathway 0 0 0.687773488 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Glucagon signaling pathway -0.671304348 -0.71541502 -0.766023166 kegg kegg NA NA no no no no no no Steroid biosynthesis Glucagon signaling pathway 0.616521739 0.437747036 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Glucagon signaling pathway -0.453913043 -0.76284585 -0.79047619 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Glucagon signaling pathway 0 0.507905138 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Glucagon signaling pathway 0 0 0.451737452 kegg kegg NA NA no no no no no no Taste transduction Glucagon signaling pathway 0.426086957 0.648221344 0 kegg kegg NA NA no no up no no no TGF-beta signaling pathway Glucagon signaling pathway 0 0.541501976 0.401544402 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Glucagon signaling pathway -0.451304348 -0.489130435 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Glucagon signaling pathway -0.426086957 -0.5 0 kegg kegg NA NA no no no no no no Thermogenesis Glucagon signaling pathway 0.474782609 0.785573123 0 kegg kegg NA NA no no no no no no Thiamine metabolism Glucagon signaling pathway 0 0.442687747 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Glucagon signaling pathway 0 0.442687747 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Glucagon signaling pathway 0.669565217 0.677865613 0 kegg kegg NA NA no no no no no no Tight junction Glucagon signaling pathway 0 0 -0.442213642 kegg kegg NA NA no no no no no no TNF signaling pathway Glucagon signaling pathway 0 -0.615612648 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Glucagon signaling pathway 0 -0.803359684 0 yes kegg kegg NA NA no no no no no no Tyrosine metabolism Glucagon signaling pathway 0 0.540513834 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Glucagon signaling pathway 0.54 0.799407115 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Glucagon signaling pathway 0 0.449604743 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Glucagon signaling pathway 0.5 0.497035573 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Glucagon signaling pathway 0.631304348 0.67687747 0.442985843 kegg kegg NA NA no no no no no no VEGF signaling pathway Glucagon signaling pathway 0 -0.482213439 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Glucagon signaling pathway 0 0.751976285 0.509137709 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Glutamatergic synapse 0 -0.598814229 -0.738996139 kegg kegg NA NA no no no no up up ABC transporters Glutamatergic synapse -0.719130435 0 -0.44041184 kegg kegg NA NA no up up no up up Adrenergic signaling in cardiomyocytes Glutamatergic synapse 0.516521739 0 0 kegg kegg NA NA no no up no up up "Alanine, aspartate and glutamate metabolism" Glutamatergic synapse 0 0.42687747 0.41956242 kegg kegg NA NA no no no no up up alpha-Linolenic acid metabolism Glutamatergic synapse -0.479130435 0 -0.44993565 kegg kegg NA NA no no no no up up Amino sugar and nucleotide sugar metabolism Glutamatergic synapse 0 0 -0.400514801 kegg kegg NA NA no no no no up up Aminoacyl-tRNA biosynthesis Glutamatergic synapse -0.522608696 -0.455533597 0 kegg kegg NA NA no no no no up up AMPK signaling pathway Glutamatergic synapse 0 0 0.505791506 kegg kegg NA NA no no no no up up Antifolate resistance Glutamatergic synapse -0.410434783 0 0 kegg kegg NA NA no no no no up up Apelin signaling pathway Glutamatergic synapse 0 -0.425889328 -0.427799228 kegg kegg NA NA no no no no up up Arachidonic acid metabolism Glutamatergic synapse 0 0 0.406949807 kegg kegg NA NA no no no no up up Arginine biosynthesis Glutamatergic synapse 0 0.458498024 0.489060489 kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism Glutamatergic synapse 0 -0.431818182 -0.73024453 kegg kegg NA NA no no no no up up Basal transcription factors Glutamatergic synapse 0 0 -0.405148005 kegg kegg NA NA no no no no up up Base excision repair Glutamatergic synapse -0.413043478 0 0 kegg kegg NA NA no no no no up up beta-Alanine metabolism Glutamatergic synapse 0 -0.517786561 0 kegg kegg NA NA no no no no up up Bifidobacterium Glutamatergic synapse 0 -0.450719559 0 acetate-producing Genus kegg 0.105 NA no dn no no up up Biosynthesis of cofactors Glutamatergic synapse 0 0 0.509137709 kegg kegg NA NA no no no no up up Butanoate metabolism Glutamatergic synapse -0.43826087 -0.595849802 0 kegg kegg NA NA no no no no up up Calcium signaling pathway Glutamatergic synapse 0.473043478 0 0 kegg kegg NA NA no up up no up up cAMP signaling pathway Glutamatergic synapse 0 0.469367589 0.489317889 yes kegg kegg NA NA no up up no up up Carbon metabolism Glutamatergic synapse 0 -0.57312253 0 kegg kegg NA NA no no no no up up Circadian entrainment Glutamatergic synapse 0.660869565 0 0.674131274 kegg kegg NA NA no up up no up up Circadian rhythm Glutamatergic synapse 0 0 -0.403346203 kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) Glutamatergic synapse -0.433043478 -0.654150198 -0.692406692 kegg kegg NA NA no no no no up up Clostridium Glutamatergic synapse 0 -0.511440348 0 Genus kegg 0.925 NA no no no no up up Cysteine and methionine metabolism Glutamatergic synapse 0 -0.639328063 0 kegg kegg NA NA no no no no up up DNA replication Glutamatergic synapse -0.486086957 -0.42687747 -0.513513514 kegg kegg NA NA no no no no up up Drug metabolism - cytochrome P450 Glutamatergic synapse 0 -0.490118577 -0.428571429 kegg kegg NA NA no no no no up up Drug metabolism - other enzymes Glutamatergic synapse 0 -0.593873518 -0.532303732 kegg kegg NA NA no no no no up up EGFR tyrosine kinase inhibitor resistance Glutamatergic synapse 0 -0.46541502 0 kegg kegg NA NA no no no no up up Endocrine resistance Glutamatergic synapse 0.549565217 0.488142292 0.63963964 kegg kegg NA NA no no no no up up Ether lipid metabolism Glutamatergic synapse 0 0 -0.520720721 kegg kegg NA NA no no no no up up Fanconi anemia pathway Glutamatergic synapse -0.460869565 0 -0.467696268 kegg kegg NA NA no no no no up up Fatty acid elongation Glutamatergic synapse 0 -0.470355731 0 kegg kegg NA NA no no no no up up Ferroptosis Glutamatergic synapse 0.588695652 0.470355731 0.487258687 kegg kegg NA NA no no no no up up Folate biosynthesis Glutamatergic synapse -0.55826087 -0.511857708 0 kegg kegg NA NA no no no no up up Fructose and mannose metabolism Glutamatergic synapse 0 0 -0.421621622 kegg kegg NA NA no no no no up up Galactose metabolism Glutamatergic synapse 0 0 -0.651994852 kegg kegg NA NA no no no no up up Gap junction Glutamatergic synapse 0.745217391 0.809288538 0.801029601 kegg kegg NA NA no no no no up up Glutathione metabolism Glutamatergic synapse 0 0 0.478507079 kegg kegg NA NA no no no no up up Glycerolipid metabolism Glutamatergic synapse -0.508695652 0 -0.727155727 kegg kegg NA NA no no up no up up Glycerophospholipid metabolism Glutamatergic synapse 0 0 -0.631660232 kegg kegg NA NA no no up no up up "Glycine, serine and threonine metabolism" Glutamatergic synapse 0 0 0.549292149 kegg kegg NA NA no up no no up up Glycolysis / Gluconeogenesis Glutamatergic synapse 0 -0.741106719 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Glutamatergic synapse 0 0.542490119 -0.474903475 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Glutamatergic synapse 0 0 -0.815444015 kegg kegg NA NA no no no no up up Glycosaminoglycan degradation Glutamatergic synapse 0 0 -0.712483912 kegg kegg NA NA no no up no up up Hedgehog signaling pathway Glutamatergic synapse 0 0 -0.517117117 kegg kegg NA NA no no no no up up Hematopoietic cell lineage Glutamatergic synapse 0 -0.744071146 0 kegg kegg NA NA no no no no up up HIF-1 signaling pathway Glutamatergic synapse 0 -0.583003953 -0.412097812 kegg kegg NA NA no no no no up up Hippo signaling pathway Glutamatergic synapse 0 -0.423913043 0 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Glutamatergic synapse -0.416521739 0 -0.470527671 kegg kegg NA NA no no no no up up Histidine metabolism Glutamatergic synapse 0 0 -0.406692407 kegg kegg NA NA no no no no up up Inositol phosphate metabolism Glutamatergic synapse -0.49826087 0 -0.56988417 kegg kegg NA NA no no no no up up Intestinal immune network for IgA production Glutamatergic synapse 0 -0.610671937 0 kegg kegg NA NA no no no no up up JAK-STAT signaling pathway Glutamatergic synapse 0 0.416996047 0 kegg kegg NA NA no no no no up up Long-term potentiation Glutamatergic synapse 0 -0.515810277 0 kegg kegg NA NA no no up no up up Longevity regulating pathway Glutamatergic synapse 0.405217391 0.528656126 0.472586873 kegg kegg NA NA no no no no up up Lysine degradation Glutamatergic synapse -0.563478261 0 -0.635778636 kegg kegg NA NA no no no no up up Mannose type O-glycan biosynthesis Glutamatergic synapse 0 0 -0.594851995 kegg kegg NA NA no no no no up up MAPK signaling pathway Glutamatergic synapse 0 0 -0.466409266 kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 Glutamatergic synapse 0 -0.537549407 0 kegg kegg NA NA no no no no up up Mismatch repair Glutamatergic synapse -0.425217391 0 0 kegg kegg NA NA no no no no up up mRNA surveillance pathway Glutamatergic synapse 0 0 -0.4002574 kegg kegg NA NA no no no no up up mTOR signaling pathway Glutamatergic synapse 0 -0.48715415 0 kegg kegg NA NA no no no no up up N-Glycan biosynthesis Glutamatergic synapse 0 -0.425889328 0 kegg kegg NA NA no no no no up up Necroptosis Glutamatergic synapse 0.522608696 0 0.489060489 kegg kegg NA NA no no no no up up NF-kappa B signaling pathway Glutamatergic synapse -0.534782609 0 0 kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Glutamatergic synapse 0 0.473320158 0 kegg kegg NA NA no no no no up up Nitrogen metabolism Glutamatergic synapse 0 0.551383399 0.625740026 kegg kegg NA NA no no no no up up Non-homologous end-joining Glutamatergic synapse 0 -0.561264822 0 kegg kegg NA NA no no no no up up Notch signaling pathway Glutamatergic synapse 0 0.457509881 -0.604375804 kegg kegg NA NA no no no no up up Nucleotide excision repair Glutamatergic synapse -0.465217391 0 0 kegg kegg NA NA no no no no up up Odoribacter Glutamatergic synapse 0 -0.480437333 0 butyrate-producing Genus kegg 0.798 NA no no no no up up One carbon pool by folate Glutamatergic synapse 0 0 -0.577091377 kegg kegg NA NA no no no no up up Oocyte meiosis Glutamatergic synapse 0 -0.585968379 0 kegg kegg NA NA no no no no up up Other glycan degradation Glutamatergic synapse -0.540869565 0 -0.682368082 kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis Glutamatergic synapse 0 0 -0.488030888 kegg kegg NA NA no no no no up up Pentose and glucuronate interconversions Glutamatergic synapse 0 -0.613636364 -0.615701416 kegg kegg NA NA no no no no up up Phenylalanine metabolism Glutamatergic synapse 0 -0.497035573 0 kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system Glutamatergic synapse 0 0 -0.498326898 kegg kegg NA NA no no no no up up Phospholipase D signaling pathway Glutamatergic synapse 0 0.754940711 0 kegg kegg NA NA no up up no up up PI3K-Akt signaling pathway Glutamatergic synapse -0.511304348 0 0 yes kegg kegg NA NA no up up no up up Porphyrin and chlorophyll metabolism Glutamatergic synapse 0 0 0.525096525 kegg kegg NA NA no no no no up up Prevotella Glutamatergic synapse -0.43788027 0 0 Genus kegg 0.367 NA no no no no up up Primary bile acid biosynthesis Glutamatergic synapse 0 -0.523715415 0 kegg kegg NA NA no no no no up up Propanoate metabolism Glutamatergic synapse 0 -0.639328063 0 kegg kegg NA NA no no no no up up Proteasome Glutamatergic synapse 0 -0.778656126 -0.556241956 kegg kegg NA NA no no no no up up Protein export Glutamatergic synapse 0 -0.577075099 -0.4998713 kegg kegg NA NA no no no no up up Pyruvate metabolism Glutamatergic synapse -0.434782609 -0.591897233 0 kegg kegg NA NA no no no no up up Retinol metabolism Glutamatergic synapse 0 0 -0.531016731 kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes Glutamatergic synapse 0 0 -0.528700129 kegg kegg NA NA no no no no up up RNA degradation Glutamatergic synapse 0 -0.460474308 -0.593050193 kegg kegg NA NA no no no no up up RNA polymerase Glutamatergic synapse 0 0 -0.511969112 kegg kegg NA NA no no no no up up RNA transport Glutamatergic synapse -0.53826087 -0.58201581 0 kegg kegg NA NA no no no no up up Selenocompound metabolism Glutamatergic synapse 0 0 -0.541312741 kegg kegg NA NA no no no no up up SNARE interactions in vesicular transport Glutamatergic synapse -0.66 0 -0.406949807 kegg kegg NA NA no no no no up up Sphingolipid metabolism Glutamatergic synapse 0 0 -0.525096525 kegg kegg NA NA no no no no up up Steroid hormone biosynthesis Glutamatergic synapse 0 0 -0.537451737 kegg kegg NA NA no no no no up up T cell receptor signaling pathway Glutamatergic synapse -0.460869565 0 0 kegg kegg NA NA no no no no up up Taurine and hypotaurine metabolism Glutamatergic synapse 0 0.506916996 0 kegg kegg NA NA no no no no up up Terpenoid backbone biosynthesis Glutamatergic synapse 0 0 -0.497812098 kegg kegg NA NA no no no no up up TGF-beta signaling pathway Glutamatergic synapse 0 -0.507905138 0 kegg kegg NA NA no no no no up up Th1 and Th2 cell differentiation Glutamatergic synapse 0 0 -0.51042471 kegg kegg NA NA no no no no up up Th17 cell differentiation Glutamatergic synapse 0 0 -0.489060489 kegg kegg NA NA no no no no up up Thiamine metabolism Glutamatergic synapse -0.523478261 0 0 kegg kegg NA NA no no no no up up Tryptophan metabolism Glutamatergic synapse -0.411304348 -0.589920949 -0.461776062 kegg kegg NA NA no up no no up up Ubiquinone and other terpenoid-quinone biosynthesis Glutamatergic synapse -0.413043478 0 -0.422393822 kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" Glutamatergic synapse -0.486086957 -0.477272727 -0.456885457 kegg kegg NA NA no no no no up up Various types of N-glycan biosynthesis Glutamatergic synapse 0 -0.437747036 -0.456885457 kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Glutamatergic synapse 0.446086957 0 0.532303732 kegg kegg NA NA no no no no up up Wnt signaling pathway Glutamatergic synapse 0 0 -0.521235521 kegg kegg NA NA no no no no up up "Alanine, aspartate and glutamate metabolism" Glutathione metabolism 0 -0.536561265 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Glutathione metabolism 0 -0.537549407 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Glutathione metabolism 0 -0.502964427 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Glutathione metabolism 0 0 -0.403346203 kegg kegg NA NA no no no no no no Butyricimonas Glutathione metabolism -0.422451042 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no Citrate cycle (TCA cycle) Glutathione metabolism 0 0.447628458 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Glutathione metabolism 0 0.550395257 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Glutathione metabolism 0 -0.646245059 0 kegg kegg NA NA no no no no no no Fatty acid degradation Glutathione metabolism 0 -0.614624506 0 kegg kegg NA NA no no no no no no Galactose metabolism Glutathione metabolism 0 -0.735177866 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Glutathione metabolism 0.609565217 0.615612648 0.787902188 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Glutathione metabolism 0 0.435770751 0 kegg kegg NA NA no no no no no no Lysine degradation Glutathione metabolism 0 0 -0.507078507 kegg kegg NA NA no no no no no no Oxidative phosphorylation Glutathione metabolism 0 0.673913043 0 kegg kegg NA NA no no no no no no Paraprevotella Glutathione metabolism 0 0 0.478146677 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Glutathione metabolism 0 0.450592885 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Glutathione metabolism 0 -0.545454545 0 kegg kegg NA NA no no no no no no Purine metabolism Glutathione metabolism 0.655652174 0.636363636 0.502960103 kegg kegg NA NA no no no no no no Pyrimidine metabolism Glutathione metabolism 0 0.555335968 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Glutathione metabolism 0 0 -0.446589447 kegg kegg NA NA no no no no no no Tyrosine metabolism Glutathione metabolism 0 0.520750988 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Glycerolipid metabolism 0 0.421936759 0 kegg kegg NA NA no no no no no up Amino sugar and nucleotide sugar metabolism Glycerolipid metabolism 0 0.553359684 0 kegg kegg NA NA no no no no no up Arginine biosynthesis Glycerolipid metabolism 0 0 -0.502445302 kegg kegg NA NA no no no no no up Ascorbate and aldarate metabolism Glycerolipid metabolism 0 0 0.612612613 kegg kegg NA NA no no no no no up Citrate cycle (TCA cycle) Glycerolipid metabolism 0 0 0.412097812 kegg kegg NA NA no no no no no up Cysteine and methionine metabolism Glycerolipid metabolism 0 -0.415019763 0 kegg kegg NA NA no no no no no up Fatty acid biosynthesis Glycerolipid metabolism 0 0.45256917 0 kegg kegg NA NA no no no no no up Fatty acid degradation Glycerolipid metabolism 0 0.524703557 0 kegg kegg NA NA no no no no no up Fructose and mannose metabolism Glycerolipid metabolism 0 0.716403162 0 kegg kegg NA NA no no no no no up Galactose metabolism Glycerolipid metabolism 0.475652174 0.685770751 0.541055341 kegg kegg NA NA no no no no no up Glutathione metabolism Glycerolipid metabolism 0 -0.513833992 -0.543371943 kegg kegg NA NA no no no no no up "Glycine, serine and threonine metabolism" Glycerolipid metabolism 0 0 -0.466151866 kegg kegg NA NA no up no no no up Glycolysis / Gluconeogenesis Glycerolipid metabolism 0 -0.619565217 0 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Glycerolipid metabolism 0 0.703557312 0.556499356 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Glycerolipid metabolism 0 0 0.728700129 kegg kegg NA NA no no no no no up Glycosaminoglycan degradation Glycerolipid metabolism 0 0 0.637323037 kegg kegg NA NA no no up no no up Histidine metabolism Glycerolipid metabolism 0.426086957 0 0 kegg kegg NA NA no no no no no up Lysine degradation Glycerolipid metabolism 0.43826087 0.604743083 0.804375804 kegg kegg NA NA no no no no no up Mannose type O-glycan biosynthesis Glycerolipid metabolism 0 0.491106719 0.815701416 kegg kegg NA NA no no no no no up Mucin type O-glycan biosynthesis Glycerolipid metabolism 0 0.442687747 0 kegg kegg NA NA no no no no no up N-Glycan biosynthesis Glycerolipid metabolism 0 0 0.477734878 kegg kegg NA NA no no no no no up Other glycan degradation Glycerolipid metabolism 0.543478261 0.789525692 0.807979408 kegg kegg NA NA no no no no no up Other types of O-glycan biosynthesis Glycerolipid metabolism 0 0.644268775 0.754182754 kegg kegg NA NA no no no no no up Oxidative phosphorylation Glycerolipid metabolism 0 -0.632411067 0 kegg kegg NA NA no no no no no up Pentose and glucuronate interconversions Glycerolipid metabolism 0 0 0.480566281 kegg kegg NA NA no no no no no up Pyrimidine metabolism Glycerolipid metabolism 0 0 0.432947233 kegg kegg NA NA no no no no no up Selenocompound metabolism Glycerolipid metabolism 0 0.682806324 0.697554698 kegg kegg NA NA no no no no no up Starch and sucrose metabolism Glycerolipid metabolism 0 0.536561265 0 kegg kegg NA NA no no no no no up Steroid hormone biosynthesis Glycerolipid metabolism 0 0 0.483655084 kegg kegg NA NA no no no no no up Taurine and hypotaurine metabolism Glycerolipid metabolism 0.503478261 0.811264822 0.637580438 kegg kegg NA NA no no no no no up Various types of N-glycan biosynthesis Glycerolipid metabolism 0 0 0.495752896 kegg kegg NA NA no no no no no up Amino sugar and nucleotide sugar metabolism Glycerophospholipid metabolism 0 0.644268775 0 kegg kegg NA NA no no no no no up Arginine biosynthesis Glycerophospholipid metabolism 0 0 -0.47953668 kegg kegg NA NA no no no no no up Ascorbate and aldarate metabolism Glycerophospholipid metabolism 0 0 0.632175032 kegg kegg NA NA no no no no no up Citrate cycle (TCA cycle) Glycerophospholipid metabolism 0 0 0.444272844 kegg kegg NA NA no no no no no up Fatty acid elongation Glycerophospholipid metabolism 0 -0.503952569 0 kegg kegg NA NA no no no no no up Fructose and mannose metabolism Glycerophospholipid metabolism 0 0.623517787 0 kegg kegg NA NA no no no no no up Glutathione metabolism Glycerophospholipid metabolism 0 0 -0.513513514 kegg kegg NA NA no no no no no up Glycerolipid metabolism Glycerophospholipid metabolism 0.62173913 0.831027668 0.87953668 kegg kegg NA NA no no up no no up "Glycine, serine and threonine metabolism" Glycerophospholipid metabolism 0 0 -0.437323037 kegg kegg NA NA no up no no no up Glycolysis / Gluconeogenesis Glycerophospholipid metabolism 0 -0.64229249 0 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Glycerophospholipid metabolism 0 0.544466403 0 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Glycerophospholipid metabolism 0 0 0.612097812 kegg kegg NA NA no no no no no up Glycosaminoglycan degradation Glycerophospholipid metabolism 0 0 0.503217503 kegg kegg NA NA no no up no no up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Glycerophospholipid metabolism 0.56 0.709486166 0.41956242 kegg kegg NA NA no no no no no up Inositol phosphate metabolism Glycerophospholipid metabolism 0.609565217 0.830039526 0.888803089 kegg kegg NA NA no no no no no up Lysine degradation Glycerophospholipid metabolism 0.569565217 0.685770751 0.875160875 kegg kegg NA NA no no no no no up Mannose type O-glycan biosynthesis Glycerophospholipid metabolism 0.450434783 0.555335968 0.830888031 kegg kegg NA NA no no no no no up Mucin type O-glycan biosynthesis Glycerophospholipid metabolism 0 0.515810277 0 kegg kegg NA NA no no no no no up N-Glycan biosynthesis Glycerophospholipid metabolism 0 0 0.521750322 kegg kegg NA NA no no no no no up Other glycan degradation Glycerophospholipid metabolism 0 0.710474308 0.761132561 kegg kegg NA NA no no no no no up Other types of O-glycan biosynthesis Glycerophospholipid metabolism 0.7 0.804347826 0.894465894 kegg kegg NA NA no no no no no up Pentose and glucuronate interconversions Glycerophospholipid metabolism 0 0 0.42985843 kegg kegg NA NA no no no no no up Pentose phosphate pathway Glycerophospholipid metabolism 0 0 -0.456370656 kegg kegg NA NA no no no no no up Pyrimidine metabolism Glycerophospholipid metabolism 0 0 0.512998713 kegg kegg NA NA no no no no no up Selenocompound metabolism Glycerophospholipid metabolism 0.748695652 0.795454545 0.825482625 kegg kegg NA NA no no no no no up Steroid biosynthesis Glycerophospholipid metabolism 0 0 0.433976834 kegg kegg NA NA no no no no no up Steroid hormone biosynthesis Glycerophospholipid metabolism 0 0 0.504504505 kegg kegg NA NA no no no no no up Synthesis and degradation of ketone bodies Glycerophospholipid metabolism 0 0 0.487516088 kegg kegg NA NA no no no no no up Taurine and hypotaurine metabolism Glycerophospholipid metabolism 0.742608696 0.826086957 0.64967825 kegg kegg NA NA no no no no no up Ubiquinone and other terpenoid-quinone biosynthesis Glycerophospholipid metabolism 0 0 0.440669241 kegg kegg NA NA no no no no no up Various types of N-glycan biosynthesis Glycerophospholipid metabolism 0 0 0.495752896 kegg kegg NA NA no no no no no up Ascorbate and aldarate metabolism "Glycine, serine and threonine metabolism" 0 0 -0.490862291 kegg kegg NA NA no no no no up no Citrate cycle (TCA cycle) "Glycine, serine and threonine metabolism" 0 0 -0.52046332 kegg kegg NA NA no no no no up no Collinsella "Glycine, serine and threonine metabolism" 0.492602449 0 0 Genus kegg 0.128 NA no no no no up no Fatty acid biosynthesis "Glycine, serine and threonine metabolism" -0.470434783 0 0 kegg kegg NA NA no no no no up no Galactose metabolism "Glycine, serine and threonine metabolism" 0 -0.451581028 0 kegg kegg NA NA no no no no up no Pentose and glucuronate interconversions "Glycine, serine and threonine metabolism" 0 0 -0.528442728 kegg kegg NA NA no no no no up no Pentose phosphate pathway "Glycine, serine and threonine metabolism" 0 -0.576086957 0 kegg kegg NA NA no no no no up no Purine metabolism "Glycine, serine and threonine metabolism" 0.639130435 0.908102767 0.563963964 kegg kegg NA NA no no no no up no Pyrimidine metabolism "Glycine, serine and threonine metabolism" 0 0.448616601 0 kegg kegg NA NA no no no no up no Synthesis and degradation of ketone bodies "Glycine, serine and threonine metabolism" 0 0.520750988 0 kegg kegg NA NA no no no no up no 12-ketoDCA+stool Glycine+blood 0 0 -0.523308271 stool_bileacids serum_aminoacids 0.505 0.00408 no no no dn no up 14:0-LPC+blood Glycine+blood 0 0 -0.453675214 serum_phospholipids serum_aminoacids 0.00689 0.00408 up up no dn no up 14:0/18:2-PC+blood Glycine+blood -0.554887218 0 0 serum_phospholipids serum_aminoacids 0.102 0.00408 no up no dn no up 14:0+blood Glycine+blood -0.452631579 0 -0.448888889 yes serum_fattyacid serum_aminoacids 0.00572 0.00408 up no dn dn no up 14:1/18:2-PG+blood Glycine+blood 0 0 -0.556239316 serum_phospholipids serum_aminoacids 0.00259 0.00408 no up up dn no up 16:0/14:0-PC+blood Glycine+blood 0 0 0.461880342 serum_phospholipids serum_aminoacids 0.0206 0.00408 no up up dn no up 16:0/16:1-PI+blood Glycine+blood -0.557894737 0 0 serum_phospholipids serum_aminoacids 0.262 0.00408 no no no dn no up 16:0/18:1-PC+blood Glycine+blood 0.472180451 0 0 serum_phospholipids serum_aminoacids 6.15E-07 0.00408 up up up dn no up 16:0/18:1-PE+blood Glycine+blood 0 0 -0.461880342 serum_phospholipids serum_aminoacids 0.000107 0.00408 up up no dn no up 16:0/18:2-PI+blood Glycine+blood -0.551879699 0 0 serum_phospholipids serum_aminoacids 0.269 0.00408 no no no dn no up 16:0/20:4-PC+blood Glycine+blood 0.547368421 0 0 serum_phospholipids serum_aminoacids 0.0262 0.00408 no up no dn no up 16:0/20:4-PI+blood Glycine+blood -0.606015038 0 0 serum_phospholipids serum_aminoacids 0.558 0.00408 no no no dn no up 16:0/20:5-PC+blood Glycine+blood 0 -0.549019608 0 serum_phospholipids serum_aminoacids 0.628 0.00408 no no no dn no up 16:1-LPC+blood Glycine+blood 0 0.634803922 0 serum_phospholipids serum_aminoacids 0.0241 0.00408 no up no dn no up 18:0-LPC+blood Glycine+blood -0.452631579 0 0 serum_phospholipids serum_aminoacids 0.554 0.00408 no no no dn no up 18:0/16:0-PC+blood Glycine+blood 0.491729323 0 0 serum_phospholipids serum_aminoacids 9.64E-07 0.00408 up up up dn no up 18:0/18:0-PC+blood Glycine+blood 0 0 0.447521368 serum_phospholipids serum_aminoacids 0.426 0.00408 no no no dn no up 18:0/18:0-PE+blood Glycine+blood 0 0 -0.617094017 serum_phospholipids serum_aminoacids 0.00896 0.00408 up up no dn no up 18:0/18:0-PS+blood Glycine+blood 0 -0.595588235 0 serum_phospholipids serum_aminoacids 0.00617 0.00408 no up no dn no up 18:0/18:1-PC+blood Glycine+blood 0 0 0.453675214 serum_phospholipids serum_aminoacids 0.393 0.00408 no no no dn no up 18:0/18:1-PE+blood Glycine+blood 0 0 -0.641025641 serum_phospholipids serum_aminoacids 0.00716 0.00408 up up no dn no up 18:0/18:1-PG+blood Glycine+blood 0 0 -0.572649573 serum_phospholipids serum_aminoacids 0.000842 0.00408 no up no dn no up 18:0/20:3-PC+blood Glycine+blood -0.562406015 0 0 serum_phospholipids serum_aminoacids 0.0682 0.00408 no up no dn no up 18:0/22:6-PI+blood Glycine+blood -0.562406015 0 0 serum_phospholipids serum_aminoacids 0.425 0.00408 no no no dn no up 18:1/16:0-PE+blood Glycine+blood 0 0 -0.638974359 serum_phospholipids serum_aminoacids 0.000182 0.00408 up up no dn no up 18:1/16:1-PE+blood Glycine+blood 0 0 -0.421538462 serum_phospholipids serum_aminoacids 0.000184 0.00408 up up no dn no up 18:1/18:0-PE+blood Glycine+blood 0 0 -0.654017094 serum_phospholipids serum_aminoacids 1.39E-06 0.00408 up up no dn no up 18:1/18:1-PE+blood Glycine+blood 0 0 -0.614358974 serum_phospholipids serum_aminoacids 1.03E-05 0.00408 up up no dn no up 18:1/18:2-PE+blood Glycine+blood 0 0 -0.528205128 serum_phospholipids serum_aminoacids 0.000293 0.00408 up up no dn no up 18:1/20:4-PE+blood Glycine+blood 0 0 -0.481025641 serum_phospholipids serum_aminoacids 0.0578 0.00408 up no no dn no up 18:2-LPA+blood Glycine+blood 0 0.56372549 0 serum_phospholipids serum_aminoacids 0.00684 0.00408 dn no up dn no up 18:3/16:0-PE+blood Glycine+blood 0 0 -0.401709402 serum_phospholipids serum_aminoacids 0.00149 0.00408 up up no dn no up 18:3n6+blood Glycine+blood 0 -0.534313725 0 serum_fattyacid serum_aminoacids 0.0463 0.00408 up no dn dn no up 20:0/20:4-PE+blood Glycine+blood 0 0 -0.476239316 serum_phospholipids serum_aminoacids 0.00128 0.00408 up up no dn no up 20:1-LPC+blood Glycine+blood 0 0 0.492649573 serum_phospholipids serum_aminoacids 0.217 0.00408 no no no dn no up 20:1/20:4-PE+blood Glycine+blood 0 0 -0.507008547 serum_phospholipids serum_aminoacids 0.0042 0.00408 up up no dn no up 20:1+blood Glycine+blood 0.490225564 0 0 yes serum_fattyacid serum_aminoacids 2.56E-05 0.00408 dn dn dn dn no up 20:2-LPC+blood Glycine+blood 0 0 0.405128205 serum_phospholipids serum_aminoacids 0.119 0.00408 no no up dn no up 20:2/18:0-PC+blood Glycine+blood -0.566917293 0 0 serum_phospholipids serum_aminoacids 0.0427 0.00408 no up no dn no up 20:2/18:1-PE+blood Glycine+blood 0 0 -0.474188034 serum_phospholipids serum_aminoacids 0.00208 0.00408 up up no dn no up 20:3/16:0-PC+blood Glycine+blood 0.566917293 0 0 serum_phospholipids serum_aminoacids 0.00405 0.00408 no up up dn no up 20:3/18:0-PC+blood Glycine+blood 0 0 0.66974359 serum_phospholipids serum_aminoacids 0.296 0.00408 no no no dn no up 20:4-LPE+blood Glycine+blood 0 0 0.461880342 serum_phospholipids serum_aminoacids 0.552 0.00408 no no no dn no up 20:4/16:0-PE+blood Glycine+blood 0 0 -0.402393162 serum_phospholipids serum_aminoacids 0.00529 0.00408 no up up dn no up 20:5n3+blood Glycine+blood 0 -0.50245098 0 serum_fattyacid serum_aminoacids 0.988 0.00408 no no no dn no up 22:0/16:0-PE+blood Glycine+blood 0 0 0.471452991 serum_phospholipids serum_aminoacids 0.091 0.00408 no no up dn no up 22:6n3+blood Glycine+blood -0.47518797 0 0 serum_fattyacid serum_aminoacids 0.792 0.00408 no no no dn no up 24:1+blood Glycine+blood 0 0 0.663589744 serum_fattyacid serum_aminoacids 0.00582 0.00408 no dn dn dn no up 3-(3-Hydroxyphenyl)propanoic acid+stool Glycine+blood -0.648351648 0 0 stool_cometabolism serum_aminoacids 0.33 0.00408 no no no dn no up 8-HETE+blood Glycine+blood 0 0.580882353 0 serum_ARA serum_aminoacids 0.741 0.00408 no no no dn no up ACA+blood Glycine+blood 0 0 0.449721816 serum_bileacids serum_aminoacids 0.338 0.00408 no no no dn no up Adipocytokine signaling pathway Glycine+blood 0 0.723529412 0 kegg serum_aminoacids NA 0.00408 no no no dn no up AGE-RAGE signaling pathway in diabetic complications Glycine+blood 0 0.597058824 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Amoebiasis Glycine+blood 0 0.629411765 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Amphetamine addiction Glycine+blood 0 -0.591176471 0 kegg serum_aminoacids NA 0.00408 no no no dn no up AMPK signaling pathway Glycine+blood 0 0 -0.443846154 kegg serum_aminoacids NA 0.00408 no no no dn no up Arginine and proline metabolism Glycine+blood 0 0.635294118 0 kegg serum_aminoacids NA 0.00408 no up no dn no up Asthma Glycine+blood 0 -0.505882353 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Autophagy - animal Glycine+blood 0 0.532352941 0 kegg serum_aminoacids NA 0.00408 no no no dn no up B cell receptor signaling pathway Glycine+blood 0 0.617647059 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Bifidobacterium Glycine+blood 0 0 0.411701353 acetate-producing Genus serum_aminoacids 0.105 0.00408 no dn no dn no up Bladder cancer Glycine+blood 0 0.661764706 0 kegg serum_aminoacids NA 0.00408 no no no dn no up C-type lectin receptor signaling pathway Glycine+blood 0 0.55 0 kegg serum_aminoacids NA 0.00408 no no no dn no up cAMP signaling pathway Glycine+blood 0 0.552941176 0 yes kegg serum_aminoacids NA 0.00408 no up up dn no up CDCA+blood Glycine+blood 0 -0.546568627 0 serum_bileacids serum_aminoacids 0.506 0.00408 no no no dn no up Cell cycle Glycine+blood 0 -0.558823529 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Chagas disease Glycine+blood 0 0.664705882 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Chemokine signaling pathway Glycine+blood 0 0.658823529 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Chronic myeloid leukemia Glycine+blood 0 0.535294118 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Coronavirus disease - COVID-19 Glycine+blood 0 -0.511764706 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Cystine+blood Glycine+blood 0 0 0.542564103 yes serum_aminoacids serum_aminoacids 0.00028 0.00408 up up no dn no up Cytosolic DNA-sensing pathway Glycine+blood 0 0.505882353 0 kegg serum_aminoacids NA 0.00408 no no no dn no up d18:1-14:0-SM+blood Glycine+blood 0 -0.539215686 0 serum_phospholipids serum_aminoacids 0.94 0.00408 no no no dn no up d18:1-18:0-SM+blood Glycine+blood 0.586466165 0 0 serum_phospholipids serum_aminoacids 0.97 0.00408 no no no dn no up d18:1-18:1-SM+blood Glycine+blood 0.511278195 0 0 serum_phospholipids serum_aminoacids 0.916 0.00408 no no no dn no up d18:1-20:1-SM+blood Glycine+blood 0.557894737 0 0 serum_phospholipids serum_aminoacids 0.0992 0.00408 no no no dn no up DCA+stool Glycine+blood 0 0 -0.622556391 stool_bileacids serum_aminoacids 0.195 0.00408 no no no dn no up Epithelial cell signaling in Helicobacter pylori infection Glycine+blood 0 0.758823529 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Estrogen signaling pathway Glycine+blood 0 -0.673529412 -0.404615385 kegg serum_aminoacids NA 0.00408 no no no dn no up Ethanolamine+blood Glycine+blood 0.467669173 0.620098039 0 serum_aminoacids serum_aminoacids 0.122 0.00408 up no no dn no up GABAergic synapse Glycine+blood 0 0.673529412 0 kegg serum_aminoacids NA 0.00408 no up up dn no up Gap junction Glycine+blood 0 0.570588235 0 kegg serum_aminoacids NA 0.00408 no no no dn no up GDCA+stool Glycine+blood 0 0 0.555723522 stool_bileacids serum_aminoacids 0.656 0.00408 no no no dn no up Glucagon signaling pathway Glycine+blood 0 -0.502941176 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Glutamatergic synapse Glycine+blood 0 0.611764706 0 kegg serum_aminoacids NA 0.00408 no up up dn no up Hematopoietic cell lineage Glycine+blood 0 -0.617647059 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Hepatitis B Glycine+blood 0 0.573529412 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Inflammatory mediator regulation of TRP channels Glycine+blood 0 -0.570588235 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Insulin signaling pathway Glycine+blood 0 -0.508823529 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Intestinal immune network for IgA production Glycine+blood 0 -0.547058824 0 kegg serum_aminoacids NA 0.00408 no no no dn no up iso-LCA+stool Glycine+blood 0 0 -0.541353383 stool_bileacids serum_aminoacids 0.72 0.00408 no no no dn no up LCA+stool Glycine+blood 0 0 -0.681203008 stool_bileacids serum_aminoacids 0.314 0.00408 no no no dn no up Lipid and atherosclerosis Glycine+blood 0 0.544117647 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Long-term depression Glycine+blood 0 0.573529412 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Long-term potentiation Glycine+blood 0 -0.670588235 0 kegg serum_aminoacids NA 0.00408 no no up dn no up Longevity regulating pathway Glycine+blood 0 0 -0.44 kegg serum_aminoacids NA 0.00408 no no no dn no up Malaria Glycine+blood 0 0.505882353 0 kegg serum_aminoacids NA 0.00408 no no no dn no up MicroRNAs in cancer Glycine+blood 0 0 -0.402307692 kegg serum_aminoacids NA 0.00408 no no no dn no up Neurotrophin signaling pathway Glycine+blood 0 0.538235294 0 kegg serum_aminoacids NA 0.00408 no no no dn no up NF-kappa B signaling pathway Glycine+blood 0 0.658823529 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Nicotinate and nicotinamide metabolism Glycine+blood 0 0.544117647 0 kegg serum_aminoacids NA 0.00408 no no no dn no up NOD-like receptor signaling pathway Glycine+blood 0 0.573529412 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Oocyte meiosis Glycine+blood 0 -0.685294118 0 kegg serum_aminoacids NA 0.00408 no no no dn no up p53 signaling pathway Glycine+blood 0 0 -0.456923077 kegg serum_aminoacids NA 0.00408 no no no dn no up Pancreatic cancer Glycine+blood 0 0 -0.550769231 kegg serum_aminoacids NA 0.00408 no no no dn no up Pathways in cancer Glycine+blood 0 0 -0.440769231 kegg serum_aminoacids NA 0.00408 no no no dn no up PD-L1 expression and PD-1 checkpoint pathway in cancer Glycine+blood 0 0.602941176 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Phosphatidylinositol signaling system Glycine+blood 0 -0.623529412 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Phospholipase D signaling pathway Glycine+blood 0 0.605882353 0 kegg serum_aminoacids NA 0.00408 no up up dn no up PPAR signaling pathway Glycine+blood 0 0.55 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Prion disease Glycine+blood 0 -0.520588235 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Propionic acid+stool Glycine+blood 0 0 -0.703759398 yes stool_scfa serum_aminoacids 0.0436 0.00408 dn no up dn no up Prostate cancer Glycine+blood 0 0.608823529 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Proteasome Glycine+blood 0 -0.526470588 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Ras signaling pathway Glycine+blood 0 -0.517647059 0 yes kegg serum_aminoacids NA 0.00408 no up up dn no up Relaxin signaling pathway Glycine+blood 0 0.567647059 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Ribosome Glycine+blood 0 -0.511764706 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Ribosome biogenesis in eukaryotes Glycine+blood 0 -0.658823529 0 kegg serum_aminoacids NA 0.00408 no no no dn no up RIG-I-like receptor signaling pathway Glycine+blood 0 0.664705882 0 kegg serum_aminoacids NA 0.00408 no no no dn no up RNA degradation Glycine+blood 0 -0.638235294 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Small cell lung cancer Glycine+blood 0 0.511764706 0 kegg serum_aminoacids NA 0.00408 no no up dn no up Spinocerebellar ataxia Glycine+blood 0 -0.573529412 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Th1 and Th2 cell differentiation Glycine+blood 0.489473684 0 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Thermogenesis Glycine+blood 0 -0.505882353 0 kegg serum_aminoacids NA 0.00408 no no no dn no up TNF signaling pathway Glycine+blood 0 0.6 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Toll-like receptor signaling pathway Glycine+blood 0 0.676470588 0 yes kegg serum_aminoacids NA 0.00408 no no no dn no up Transcriptional misregulation in cancer Glycine+blood 0 0.561764706 -0.44 kegg serum_aminoacids NA 0.00408 no no no dn no up Wnt signaling pathway Glycine+blood 0 -0.6 0 kegg serum_aminoacids NA 0.00408 no no no dn no up Bacteroides Glycolysis / Gluconeogenesis 0 0.578063241 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Bifidobacterium Glycolysis / Gluconeogenesis 0 0.477960851 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Clostridium Glycolysis / Gluconeogenesis 0 0.568493454 0 Genus kegg 0.925 NA no no no no no no Dorea Glycolysis / Gluconeogenesis 0 0.451692626 0 Genus kegg 0.00362 NA up no dn no no no Lachnospira Glycolysis / Gluconeogenesis 0 0.423523611 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Odoribacter Glycolysis / Gluconeogenesis 0 0.504706847 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Parabacteroides Glycolysis / Gluconeogenesis 0.488695652 0 0 Genus kegg 4.19E-05 NA no up up no no no Paraprevotella Glycolysis / Gluconeogenesis 0.505831203 0 0 Genus kegg 0.118 NA no no no no no no Prevotella Glycolysis / Gluconeogenesis 0 -0.467631712 -0.427916446 acetate-producing Genus kegg 0.287 NA no no no no no no "Alanine, aspartate and glutamate metabolism" Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.733043478 0.729249012 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.592173913 0.700592885 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.762608696 0.681818182 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.416007905 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.502964427 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.798418972 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.465217391 -0.831027668 -0.435778636 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.673043478 0.745059289 0 kegg kegg NA NA no no no no no no Fatty acid degradation Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.436521739 0.586956522 0 kegg kegg NA NA no no no no no no Fatty acid elongation Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.550395257 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.700592885 0 kegg kegg NA NA no no no no no no Galactose metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.619565217 0.515572716 kegg kegg NA NA no no no no no no Glutathione metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.663043478 -0.495238095 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.833003953 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.486086957 0 0.688545689 kegg kegg NA NA no no up no no no N-Glycan biosynthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.58 -0.609683794 0 kegg kegg NA NA no no no no no no Other glycan degradation Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.558300395 0.547232947 kegg kegg NA NA no no no no no no Oxidative phosphorylation Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.748023715 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.624347826 -0.767786561 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.665217391 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.664031621 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.424347826 -0.650197628 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.565217391 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.526086957 0.669960474 0.448133848 kegg kegg NA NA no no no no no no Steroid biosynthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.603478261 -0.619565217 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.523715415 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.468695652 -0.517786561 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.751976285 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.633399209 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.411304348 -0.690711462 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.51284585 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.621541502 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.42687747 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.626482213 -0.52998713 kegg kegg NA NA no no no no no no Arginine and proline metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.477272727 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.668972332 -0.584555985 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.421936759 0.653281853 kegg kegg NA NA no no no no no no beta-Alanine metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.632173913 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.595652174 0.497035573 0.586357786 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.541501976 0 kegg kegg NA NA no no no no no no Fatty acid elongation Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.456521739 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.459130435 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.409565217 0 0.555984556 kegg kegg NA NA no no no no no no Glutathione metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.45045045 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.553925354 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.576521739 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.568597169 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.57312253 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.72020592 kegg kegg NA NA no no up no no no Lysine degradation Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.541501976 0.633719434 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.538537549 0.634234234 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.758893281 0.443243243 kegg kegg NA NA no no no no no no Other glycan degradation Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.656113256 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.502187902 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.48 0.630434783 0.553667954 kegg kegg NA NA no no no no no no Phenylalanine metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.812173913 0.583003953 0 kegg kegg NA NA no no no no no no Purine metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.41003861 kegg kegg NA NA no no no no no no Pyrimidine metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.575098814 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.487516088 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.431818182 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.603861004 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.412173913 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.640869565 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.543478261 0.415019763 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.447826087 0.542490119 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.522608696 0.59486166 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.796442688 0.473873874 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Glycosaminoglycan biosynthesis - keratan sulfate -0.459130435 -0.544466403 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.746956522 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.631304348 -0.428853755 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate -0.494782609 -0.559288538 -0.407207207 kegg kegg NA NA no no no no no no beta-Alanine metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.484347826 -0.460474308 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.471304348 0 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate -0.465217391 -0.496047431 0 kegg kegg NA NA no no no no no no Fatty acid degradation Glycosaminoglycan biosynthesis - keratan sulfate -0.609565217 -0.579051383 -0.406949807 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.57826087 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.56173913 0 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Glycosaminoglycan biosynthesis - keratan sulfate -0.610434783 0 -0.475418275 kegg kegg NA NA no no no no no no Histidine metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.487826087 -0.561264822 0 kegg kegg NA NA no no no no no no Lysine degradation Glycosaminoglycan biosynthesis - keratan sulfate 0 0.48715415 0.471042471 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate 0.769565217 0.751976285 0.603346203 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate -0.569565217 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate 0 0.514822134 0.520978121 kegg kegg NA NA no no no no no no Other glycan degradation Glycosaminoglycan biosynthesis - keratan sulfate -0.543478261 0 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.495495495 kegg kegg NA NA no no no no no no Oxidative phosphorylation Glycosaminoglycan biosynthesis - keratan sulfate 0.490434783 0 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Glycosaminoglycan biosynthesis - keratan sulfate 0 0 -0.579407979 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate -0.436521739 -0.467391304 -0.4002574 kegg kegg NA NA no no no no no no Pyrimidine metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.593913043 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.674782609 -0.546442688 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate -0.577391304 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Glycosaminoglycan biosynthesis - keratan sulfate -0.416521739 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate -0.413913043 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Glycosaminoglycan biosynthesis - keratan sulfate -0.407826087 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate 0 0.535573123 0.434749035 kegg kegg NA NA no no no no no no Arginine and proline metabolism Glycosaminoglycan degradation 0 0.498023715 0 kegg kegg NA NA no up no no no up Ascorbate and aldarate metabolism Glycosaminoglycan degradation 0 0 0.497554698 kegg kegg NA NA no no no no no up Cysteine and methionine metabolism Glycosaminoglycan degradation -0.51826087 -0.445652174 0 kegg kegg NA NA no no no no no up Fructose and mannose metabolism Glycosaminoglycan degradation 0 0 0.43963964 kegg kegg NA NA no no no no no up Galactose metabolism Glycosaminoglycan degradation 0 0 0.701158301 kegg kegg NA NA no no no no no up Glutathione metabolism Glycosaminoglycan degradation 0 -0.567193676 -0.498584299 kegg kegg NA NA no no no no no up "Glycine, serine and threonine metabolism" Glycosaminoglycan degradation 0 -0.70256917 -0.579407979 kegg kegg NA NA no up no no no up Histidine metabolism Glycosaminoglycan degradation 0 0.419960474 0 kegg kegg NA NA no no no no no up Lysine degradation Glycosaminoglycan degradation 0 0 0.403346203 kegg kegg NA NA no no no no no up Mannose type O-glycan biosynthesis Glycosaminoglycan degradation 0 0 0.441956242 kegg kegg NA NA no no no no no up N-Glycan biosynthesis Glycosaminoglycan degradation -0.593913043 0 0 kegg kegg NA NA no no no no no up Other glycan degradation Glycosaminoglycan degradation 0 0 0.720720721 kegg kegg NA NA no no no no no up Other types of O-glycan biosynthesis Glycosaminoglycan degradation -0.410434783 -0.443675889 0 kegg kegg NA NA no no no no no up Pentose phosphate pathway Glycosaminoglycan degradation 0.653913043 0.65513834 0 kegg kegg NA NA no no no no no up Purine metabolism Glycosaminoglycan degradation 0 -0.683794466 -0.497039897 kegg kegg NA NA no no no no no up Selenocompound metabolism Glycosaminoglycan degradation -0.514782609 0 0 kegg kegg NA NA no no no no no up Starch and sucrose metabolism Glycosaminoglycan degradation 0 0.496047431 0.6 kegg kegg NA NA no no no no no up Steroid biosynthesis Glycosaminoglycan degradation -0.436521739 0 0 kegg kegg NA NA no no no no no up Steroid hormone biosynthesis Glycosaminoglycan degradation 0 0 0.470785071 kegg kegg NA NA no no no no no up Synthesis and degradation of ketone bodies Glycosaminoglycan degradation -0.551304348 0 0 kegg kegg NA NA no no no no no up Various types of N-glycan biosynthesis Glycosaminoglycan degradation -0.44173913 0 0 kegg kegg NA NA no no no no no up Amino sugar and nucleotide sugar metabolism Glycosphingolipid biosynthesis - ganglio series 0 0.544466403 0.425225225 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Glycosphingolipid biosynthesis - ganglio series 0.431304348 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Glycosphingolipid biosynthesis - ganglio series 0 -0.421936759 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Glycosphingolipid biosynthesis - ganglio series 0 -0.454545455 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Glycosphingolipid biosynthesis - ganglio series 0 0.588932806 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Glycosphingolipid biosynthesis - ganglio series 0 0.651185771 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Glycosphingolipid biosynthesis - ganglio series 0.470434783 0.490118577 0.575032175 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Glycosphingolipid biosynthesis - ganglio series 0 -0.424901186 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Glycosphingolipid biosynthesis - ganglio series 0 0 0.444015444 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Glycosphingolipid biosynthesis - ganglio series 0 0 0.496782497 kegg kegg NA NA no no up no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Glycosphingolipid biosynthesis - ganglio series 0 0.618577075 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Glycosphingolipid biosynthesis - ganglio series 0 0.46541502 0.441698842 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - ganglio series 0.414782609 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Glycosphingolipid biosynthesis - ganglio series 0 0 0.465894466 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Glycosphingolipid biosynthesis - ganglio series 0 0.431818182 0.478764479 kegg kegg NA NA no no no no no no Lysine degradation Glycosphingolipid biosynthesis - ganglio series 0 0.550395257 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Glycosphingolipid biosynthesis - ganglio series 0 0.434782609 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Glycosphingolipid biosynthesis - ganglio series 0 0.424901186 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Glycosphingolipid biosynthesis - ganglio series 0 0.639328063 0 kegg kegg NA NA no no no no no no Other glycan degradation Glycosphingolipid biosynthesis - ganglio series 0 0 0.420849421 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Glycosphingolipid biosynthesis - ganglio series 0 0.449604743 0.451737452 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Glycosphingolipid biosynthesis - ganglio series 0 0.673913043 0.455855856 kegg kegg NA NA no no no no no no Pentose phosphate pathway Glycosphingolipid biosynthesis - ganglio series 0 -0.463438735 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Glycosphingolipid biosynthesis - ganglio series 0 0.592885375 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Glycosphingolipid biosynthesis - ganglio series 0 0.657114625 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Glycosphingolipid biosynthesis - ganglio series 0 0.657114625 0.482368082 kegg kegg NA NA no no no no no no Steroid biosynthesis Glycosphingolipid biosynthesis - ganglio series 0 0.543478261 0.444272844 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Glycosphingolipid biosynthesis - ganglio series 0 0.496047431 0.451480051 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Glycosphingolipid biosynthesis - ganglio series 0 0.661067194 0.423938224 kegg kegg NA NA no no no no no no Tryptophan metabolism Glycosphingolipid biosynthesis - ganglio series 0 0.553359684 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Glycosphingolipid biosynthesis - ganglio series 0 0.509881423 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Glycosphingolipid biosynthesis - ganglio series 0 0.757905138 0.534105534 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Glycosphingolipid biosynthesis - ganglio series 0 0.730237154 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Glycosphingolipid biosynthesis - ganglio series 0 0.695652174 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Glycosphingolipid biosynthesis - globo and isoglobo series 0.419130435 0 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Glycosphingolipid biosynthesis - globo and isoglobo series 0 0.47826087 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Glycosphingolipid biosynthesis - globo and isoglobo series -0.502608696 0 0 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Glycosphingolipid biosynthesis - globo and isoglobo series 0.482608696 0 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Glycosphingolipid biosynthesis - globo and isoglobo series -0.584347826 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Glycosphingolipid biosynthesis - globo and isoglobo series -0.56173913 0 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Glycosphingolipid biosynthesis - globo and isoglobo series 0.42 0 -0.522265122 kegg kegg NA NA no no no no no no Lysine degradation Glycosphingolipid biosynthesis - globo and isoglobo series -0.517391304 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Glycosphingolipid biosynthesis - globo and isoglobo series -0.428695652 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Glycosphingolipid biosynthesis - globo and isoglobo series -0.508695652 0 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Glycosphingolipid biosynthesis - globo and isoglobo series -0.513913043 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Glycosphingolipid biosynthesis - globo and isoglobo series -0.593913043 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Glycosphingolipid biosynthesis - globo and isoglobo series 0.466956522 0 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Glycosphingolipid biosynthesis - globo and isoglobo series -0.511304348 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Glycosphingolipid biosynthesis - globo and isoglobo series -0.427826087 0 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.512173913 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.625217391 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.474782609 0 -0.525096525 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Glycosphingolipid biosynthesis - lacto and neolacto series -0.432173913 0 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.643478261 -0.541501976 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Glycosphingolipid biosynthesis - lacto and neolacto series 0.62 0 0 kegg kegg NA NA no no no no no no Fatty acid degradation Glycosphingolipid biosynthesis - lacto and neolacto series -0.415652174 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 -0.523294723 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.456521739 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Glycosphingolipid biosynthesis - lacto and neolacto series 0 -0.434782609 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 0.45045045 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Glycosphingolipid biosynthesis - lacto and neolacto series 0.451304348 0 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Glycosphingolipid biosynthesis - lacto and neolacto series -0.76173913 -0.546442688 -0.496782497 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.526679842 0.430888031 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Glycosphingolipid biosynthesis - lacto and neolacto series 0.713913043 0.464426877 0.67953668 kegg kegg NA NA no no no no no no Lysine degradation Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 0.461776062 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Glycosphingolipid biosynthesis - lacto and neolacto series 0.782608696 0.438735178 0.615701416 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Glycosphingolipid biosynthesis - lacto and neolacto series -0.562608696 0 0 kegg kegg NA NA no no no no no no Other glycan degradation Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.418972332 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Glycosphingolipid biosynthesis - lacto and neolacto series -0.511304348 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.416521739 0 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Glycosphingolipid biosynthesis - lacto and neolacto series 0 -0.461462451 -0.500643501 kegg kegg NA NA no no no no no no Pyrimidine metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.546956522 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Glycosphingolipid biosynthesis - lacto and neolacto series 0.410434783 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Glycosphingolipid biosynthesis - lacto and neolacto series -0.46 -0.483201581 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Glycosphingolipid biosynthesis - lacto and neolacto series -0.436521739 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.408695652 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.64173913 -0.536561265 -0.476962677 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Glycosphingolipid biosynthesis - lacto and neolacto series -0.410434783 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.56916996 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.42 0.415019763 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.654150198 0 kegg kegg NA NA no up no no no no Glycosaminoglycan degradation Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.526086957 -0.463438735 0 kegg kegg NA NA no no up no no no Inositol phosphate metabolism Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.597391304 0.485177866 0 kegg kegg NA NA no no no no no no Lysine degradation Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.602608696 0.530632411 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.668695652 0 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.737391304 0.729249012 0.406177606 kegg kegg NA NA no no no no no no Pentose phosphate pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.604743083 0 kegg kegg NA NA no no no no no no Purine metabolism Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.632411067 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.643478261 0.664031621 0.44015444 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.534782609 0.531620553 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.471304348 0.434782609 0.410553411 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.411304348 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.567826087 0 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Glyoxylate and dicarboxylate metabolism 0.937391304 0.9743083 0.940797941 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Glyoxylate and dicarboxylate metabolism 0.435652174 0.583003953 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Glyoxylate and dicarboxylate metabolism 0.715652174 0.868577075 0.628056628 kegg kegg NA NA no up no no no no Arginine biosynthesis Glyoxylate and dicarboxylate metabolism 0.939130435 0.993083004 0.968597169 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Glyoxylate and dicarboxylate metabolism 0 -0.528656126 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism 0 -0.664031621 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Glyoxylate and dicarboxylate metabolism 0 -0.586956522 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Glyoxylate and dicarboxylate metabolism -0.560869565 -0.639328063 -0.465637066 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Glyoxylate and dicarboxylate metabolism 0.831304348 0.938735178 0.766280566 kegg kegg NA NA no no no no no no Fatty acid degradation Glyoxylate and dicarboxylate metabolism 0.787826087 0.748023715 0.466151866 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Glyoxylate and dicarboxylate metabolism 0.489565217 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Glyoxylate and dicarboxylate metabolism 0.554782609 0.51284585 0 kegg kegg NA NA no no no no no no Glutathione metabolism Glyoxylate and dicarboxylate metabolism 0 -0.507905138 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Glyoxylate and dicarboxylate metabolism 0.417391304 0 -0.428056628 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Glyoxylate and dicarboxylate metabolism 0 0 -0.444787645 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Glyoxylate and dicarboxylate metabolism 0 -0.421936759 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Glyoxylate and dicarboxylate metabolism 0.672173913 0.660079051 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Glyoxylate and dicarboxylate metabolism 0 -0.675889328 -0.471042471 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Glyoxylate and dicarboxylate metabolism -0.468695652 -0.565217391 -0.412097812 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Glyoxylate and dicarboxylate metabolism 0 -0.482213439 0 kegg kegg NA NA no no no no no no Lysine degradation Glyoxylate and dicarboxylate metabolism 0 0 -0.636293436 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Glyoxylate and dicarboxylate metabolism 0 -0.421936759 -0.68983269 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Glyoxylate and dicarboxylate metabolism 0 -0.876482213 -0.571428571 kegg kegg NA NA no no no no no no Other glycan degradation Glyoxylate and dicarboxylate metabolism 0.447826087 0 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Glyoxylate and dicarboxylate metabolism 0 0 -0.535135135 kegg kegg NA NA no no no no no no Oxidative phosphorylation Glyoxylate and dicarboxylate metabolism -0.672173913 -0.722332016 -0.533848134 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Glyoxylate and dicarboxylate metabolism 0 -0.840909091 -0.61029601 kegg kegg NA NA no no no no no no Pentose phosphate pathway Glyoxylate and dicarboxylate metabolism 0.496521739 0.666996047 0.807207207 kegg kegg NA NA no no no no no no Phenylalanine metabolism Glyoxylate and dicarboxylate metabolism 0 -0.608695652 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Glyoxylate and dicarboxylate metabolism 0.468695652 -0.684782609 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Glyoxylate and dicarboxylate metabolism 0 -0.644268775 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Glyoxylate and dicarboxylate metabolism 0.619130435 0.782608696 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Glyoxylate and dicarboxylate metabolism -0.412173913 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Glyoxylate and dicarboxylate metabolism 0 -0.42687747 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Glyoxylate and dicarboxylate metabolism 0 -0.461462451 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Glyoxylate and dicarboxylate metabolism 0 -0.416996047 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Glyoxylate and dicarboxylate metabolism 0 -0.549407115 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Glyoxylate and dicarboxylate metabolism 0 -0.515810277 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Glyoxylate and dicarboxylate metabolism 0 -0.654150198 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Glyoxylate and dicarboxylate metabolism 0 -0.748023715 -0.446846847 kegg kegg NA NA no no no no no no Eotaxin GM-CSF 0 -0.683116883 -0.401557286 yes serum_cytokines serum_cytokines 0.393 0.0124 no no no up no no 2-Oxocarboxylic acid metabolism GnRH secretion -0.51826087 0 0 kegg kegg NA NA no no no no up up ABC transporters GnRH secretion 0 0.60770751 0 kegg kegg NA NA no up up no up up Adherens junction GnRH secretion 0 -0.555335968 0 kegg kegg NA NA no no no no up up Adipocytokine signaling pathway GnRH secretion 0 0.447628458 0 kegg kegg NA NA no no no no up up alpha-Linolenic acid metabolism GnRH secretion -0.433913043 0 0 kegg kegg NA NA no no no no up up Amino sugar and nucleotide sugar metabolism GnRH secretion -0.648695652 0 0 kegg kegg NA NA no no no no up up Antigen processing and presentation GnRH secretion 0 -0.500988142 -0.502187902 kegg kegg NA NA no no no no up up Apelin signaling pathway GnRH secretion 0 -0.504940711 0 kegg kegg NA NA no no no no up up Apoptosis GnRH secretion 0 0.414031621 0 kegg kegg NA NA no no no no up up Apoptosis - multiple species GnRH secretion 0 0.448616601 0 kegg kegg NA NA no no no no up up Arachidonic acid metabolism GnRH secretion -0.583478261 0 -0.564221364 kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism GnRH secretion 0 -0.496047431 0 kegg kegg NA NA no no no no up up Autophagy - animal GnRH secretion 0.586956522 0.695652174 0.5997426 kegg kegg NA NA no no no no up up Autophagy - other GnRH secretion 0.474782609 0.550395257 0.637323037 kegg kegg NA NA no no no no up up Axon guidance GnRH secretion 0.447826087 0 0 kegg kegg NA NA no up up no up up B cell receptor signaling pathway GnRH secretion 0.46 0.481225296 0 kegg kegg NA NA no no no no up up Basal transcription factors GnRH secretion 0 0 0.434749035 kegg kegg NA NA no no no no up up beta-Alanine metabolism GnRH secretion -0.589565217 -0.695652174 0 kegg kegg NA NA no no no no up up Biosynthesis of amino acids GnRH secretion -0.473913043 0 -0.500643501 kegg kegg NA NA no no no no up up Biosynthesis of cofactors GnRH secretion -0.6 0 -0.464607465 kegg kegg NA NA no no no no up up Biosynthesis of unsaturated fatty acids GnRH secretion -0.492173913 -0.649209486 0 kegg kegg NA NA no no no no up up Butanoate metabolism GnRH secretion -0.60173913 -0.590909091 0 kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway GnRH secretion 0.611304348 0.538537549 0 kegg kegg NA NA no no no no up up Calcium signaling pathway GnRH secretion 0.508695652 0 0 kegg kegg NA NA no up up no up up cAMP signaling pathway GnRH secretion 0.513043478 0 0 yes kegg kegg NA NA no up up no up up Carbon metabolism GnRH secretion -0.637391304 -0.517786561 0 kegg kegg NA NA no no no no up up Cell cycle GnRH secretion 0 0 0.507078507 kegg kegg NA NA no no no no up up Cholinergic synapse GnRH secretion 0.60173913 0 0.714028314 kegg kegg NA NA no no no no up up Circadian entrainment GnRH secretion 0 -0.533596838 -0.432689833 kegg kegg NA NA no up up no up up Circadian rhythm GnRH secretion 0.582608696 0 0.622393822 kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) GnRH secretion -0.565217391 -0.677865613 0 kegg kegg NA NA no no no no up up Complement and coagulation cascades GnRH secretion 0 0 -0.481853282 kegg kegg NA NA no no no no up up Cysteine and methionine metabolism GnRH secretion -0.443478261 -0.605731225 0 kegg kegg NA NA no no no no up up Drug metabolism - cytochrome P450 GnRH secretion -0.554782609 -0.62944664 0 kegg kegg NA NA no no no no up up Drug metabolism - other enzymes GnRH secretion -0.710434783 -0.681818182 0 kegg kegg NA NA no no no no up up Endocrine resistance GnRH secretion 0.508695652 0 0 kegg kegg NA NA no no no no up up ErbB signaling pathway GnRH secretion 0.959130435 0.972332016 0.843243243 kegg kegg NA NA no no no no up up Estrogen signaling pathway GnRH secretion 0 -0.48715415 0 kegg kegg NA NA no no no no up up Ether lipid metabolism GnRH secretion 0 0 0.419305019 kegg kegg NA NA no no no no up up Fatty acid elongation GnRH secretion -0.604347826 -0.700592885 0 kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway GnRH secretion 0.766956522 0.568181818 0.466924067 kegg kegg NA NA no no no no up up Ferroptosis GnRH secretion 0 0 -0.545173745 kegg kegg NA NA no no no no up up Focal adhesion GnRH secretion 0 -0.65513834 0 kegg kegg NA NA no up up no up up FoxO signaling pathway GnRH secretion 0.48173913 0.628458498 0 kegg kegg NA NA no no no no up up Fructose and mannose metabolism GnRH secretion -0.513913043 0.568181818 0 kegg kegg NA NA no no no no up up Galactose metabolism GnRH secretion -0.426956522 0.435770751 0 kegg kegg NA NA no no no no up up Gap junction GnRH secretion 0 0 -0.438352638 kegg kegg NA NA no no no no up up Glutamatergic synapse GnRH secretion 0 0.435770751 -0.435778636 kegg kegg NA NA no up up no up up Glutathione metabolism GnRH secretion -0.436521739 -0.427865613 -0.626512227 kegg kegg NA NA no no no no up up Glycerolipid metabolism GnRH secretion 0 0.660079051 0.670785071 kegg kegg NA NA no no up no up up Glycerophospholipid metabolism GnRH secretion 0.447826087 0.522727273 0.734877735 kegg kegg NA NA no no up no up up "Glycine, serine and threonine metabolism" GnRH secretion -0.443478261 0 -0.444272844 kegg kegg NA NA no up no no up up Glycolysis / Gluconeogenesis GnRH secretion -0.677391304 -0.726284585 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate GnRH secretion 0 0.796442688 0.558043758 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin GnRH secretion -0.448695652 0 0.540797941 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate GnRH secretion 0.495652174 0 0.455855856 kegg kegg NA NA no no no no up up Glycosaminoglycan degradation GnRH secretion 0 0 0.496525097 kegg kegg NA NA no no up no up up Glycosphingolipid biosynthesis - globo and isoglobo series GnRH secretion -0.428695652 0 0 kegg kegg NA NA no no no no up up Glycosphingolipid biosynthesis - lacto and neolacto series GnRH secretion 0.547826087 0 0.435263835 kegg kegg NA NA no no no no up up Hedgehog signaling pathway GnRH secretion 0.65826087 0 0.776576577 kegg kegg NA NA no no no no up up Hematopoietic cell lineage GnRH secretion 0 -0.52173913 0 kegg kegg NA NA no no no no up up HIF-1 signaling pathway GnRH secretion 0 -0.460474308 0 kegg kegg NA NA no no no no up up Hippo signaling pathway GnRH secretion 0 -0.520750988 0 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species GnRH secretion 0 0 0.57014157 kegg kegg NA NA no no no no up up Inositol phosphate metabolism GnRH secretion 0 0.574110672 0.733075933 kegg kegg NA NA no no no no up up Insulin signaling pathway GnRH secretion 0 -0.460474308 0 kegg kegg NA NA no no no no up up JAK-STAT signaling pathway GnRH secretion 0 0.720355731 0 kegg kegg NA NA no no no no up up Linoleic acid metabolism GnRH secretion -0.543478261 0 0 kegg kegg NA NA no no no no up up Long-term potentiation GnRH secretion 0 -0.528656126 0.498069498 kegg kegg NA NA no no up no up up Longevity regulating pathway GnRH secretion 0.494782609 0 0 kegg kegg NA NA no no no no up up Lysine degradation GnRH secretion 0 0.500988142 0.70965251 kegg kegg NA NA no no no no up up Mannose type O-glycan biosynthesis GnRH secretion 0.594782609 0.514822134 0.662805663 kegg kegg NA NA no no no no up up MAPK signaling pathway GnRH secretion 0 0 0.717374517 kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 GnRH secretion -0.605217391 -0.701581028 0 kegg kegg NA NA no no no no up up Mismatch repair GnRH secretion -0.482608696 -0.482213439 0 kegg kegg NA NA no no no no up up Mitophagy - animal GnRH secretion 0 0 -0.485714286 kegg kegg NA NA no no no no up up mRNA surveillance pathway GnRH secretion 0.507826087 0 0.59021879 kegg kegg NA NA no no no no up up N-Glycan biosynthesis GnRH secretion 0 0 0.410553411 kegg kegg NA NA no no no no up up Necroptosis GnRH secretion 0 0 -0.51969112 kegg kegg NA NA no no no no up up Neurotrophin signaling pathway GnRH secretion 0.615652174 0.568181818 0 kegg kegg NA NA no no no no up up Neutrophil extracellular trap formation GnRH secretion 0 0 -0.423166023 kegg kegg NA NA no no no no up up NF-kappa B signaling pathway GnRH secretion 0.473043478 0.657114625 0 kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway GnRH secretion 0 0.449604743 0 kegg kegg NA NA no no no no up up Non-homologous end-joining GnRH secretion -0.587826087 -0.627470356 0 kegg kegg NA NA no no no no up up Notch signaling pathway GnRH secretion 0.608695652 0.705533597 0.705019305 kegg kegg NA NA no no no no up up Oocyte meiosis GnRH secretion 0 -0.637351779 0 kegg kegg NA NA no no no no up up Other glycan degradation GnRH secretion 0 0.500988142 0.611840412 kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis GnRH secretion 0 0.515810277 0.679021879 kegg kegg NA NA no no no no up up Ovarian steroidogenesis GnRH secretion 0 0 -0.424453024 kegg kegg NA NA no up up no up up Oxidative phosphorylation GnRH secretion 0 -0.422924901 0 kegg kegg NA NA no no no no up up Oxytocin signaling pathway GnRH secretion 0 -0.518774704 -0.442471042 kegg kegg NA NA no no no no up up p53 signaling pathway GnRH secretion 0.517391304 0.448616601 0 kegg kegg NA NA no no no no up up Pentose and glucuronate interconversions GnRH secretion -0.663478261 -0.554347826 0 kegg kegg NA NA no no no no up up Phenylalanine metabolism GnRH secretion -0.562608696 -0.584980237 0 kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system GnRH secretion 0.650434783 0 0.785842986 kegg kegg NA NA no no no no up up Phospholipase D signaling pathway GnRH secretion 0.532173913 0.684782609 0 kegg kegg NA NA no up up no up up Phototransduction GnRH secretion 0 -0.865612648 0 kegg kegg NA NA no no no no up up Platelet activation GnRH secretion -0.41826087 -0.537549407 0 kegg kegg NA NA no no no no up up Platinum drug resistance GnRH secretion 0.475652174 0.53458498 0.46023166 kegg kegg NA NA no no no no up up Porphyrin and chlorophyll metabolism GnRH secretion -0.435652174 0 -0.503989704 kegg kegg NA NA no no no no up up Primary bile acid biosynthesis GnRH secretion -0.528695652 -0.741106719 0 kegg kegg NA NA no no no no up up Progesterone-mediated oocyte maturation GnRH secretion 0.495652174 0.567193676 0.784555985 kegg kegg NA NA no no no no up up Prolactin signaling pathway GnRH secretion 0.720869565 0.622529644 0.522779923 kegg kegg NA NA no no no no up up Propanoate metabolism GnRH secretion -0.493043478 -0.635375494 0 kegg kegg NA NA no no no no up up Proteasome GnRH secretion 0 -0.740118577 0 kegg kegg NA NA no no no no up up Protein export GnRH secretion 0 -0.54743083 0 kegg kegg NA NA no no no no up up Pyrimidine metabolism GnRH secretion -0.503478261 0 0 kegg kegg NA NA no no no no up up Pyruvate metabolism GnRH secretion -0.451304348 -0.624505929 0 kegg kegg NA NA no no no no up up Ras signaling pathway GnRH secretion 0 0 0.567052767 yes kegg kegg NA NA no up up no up up Regulation of actin cytoskeleton GnRH secretion -0.65826087 -0.786561265 0 kegg kegg NA NA no no no no up up Relaxin signaling pathway GnRH secretion 0.467826087 0.549407115 0 kegg kegg NA NA no no no no up up Renin secretion GnRH secretion 0 -0.522727273 0 kegg kegg NA NA no no no no up up Retinol metabolism GnRH secretion -0.506956522 0 0 kegg kegg NA NA no no no no up up Retrograde endocannabinoid signaling GnRH secretion 0 -0.504940711 0 kegg kegg NA NA no no up no up up Ribosome GnRH secretion 0 -0.441699605 0 kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes GnRH secretion 0 0 0.421364221 kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway GnRH secretion 0.426086957 0.632411067 0 kegg kegg NA NA no no no no up up RNA degradation GnRH secretion 0.493913043 0 0.572715573 kegg kegg NA NA no no no no up up Selenocompound metabolism GnRH secretion 0 0 0.523809524 kegg kegg NA NA no no no no up up Serotonergic synapse GnRH secretion 0 0 -0.402316602 kegg kegg NA NA no no no no up up Signaling pathways regulating pluripotency of stem cells GnRH secretion 0.86 0.766798419 0.80978121 kegg kegg NA NA no no no no up up SNARE interactions in vesicular transport GnRH secretion 0 0.4743083 0 kegg kegg NA NA no no no no up up Sphingolipid signaling pathway GnRH secretion 0.706086957 0 0.69034749 kegg kegg NA NA no no no no up up Spliceosome GnRH secretion 0 0.514822134 0.471042471 kegg kegg NA NA no no no no up up Steroid biosynthesis GnRH secretion 0 -0.604743083 0 kegg kegg NA NA no no no no up up Steroid hormone biosynthesis GnRH secretion -0.716521739 -0.542490119 0 kegg kegg NA NA no no no no up up Sulfur metabolism GnRH secretion -0.615652174 -0.466403162 -0.492664093 kegg kegg NA NA no no no no up up T cell receptor signaling pathway GnRH secretion 0 0.549407115 0 kegg kegg NA NA no no no no up up Taste transduction GnRH secretion 0 0 0.715572716 kegg kegg NA NA no no up no up up Taurine and hypotaurine metabolism GnRH secretion 0.56 0.800395257 0.519433719 kegg kegg NA NA no no no no up up TGF-beta signaling pathway GnRH secretion 0 -0.551383399 0.50990991 kegg kegg NA NA no no no no up up Thermogenesis GnRH secretion 0 -0.422924901 0 kegg kegg NA NA no no no no up up Thiamine metabolism GnRH secretion -0.46 -0.56027668 0 kegg kegg NA NA no no no no up up Thyroid hormone synthesis GnRH secretion 0 0 -0.457400257 kegg kegg NA NA no no no no up up Tight junction GnRH secretion -0.628695652 -0.70256917 -0.475418275 kegg kegg NA NA no no no no up up TNF signaling pathway GnRH secretion 0.627826087 0.705533597 0 kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway GnRH secretion 0.533043478 0.492094862 0 yes kegg kegg NA NA no no no no up up Tryptophan metabolism GnRH secretion -0.576521739 -0.7243083 0 kegg kegg NA NA no up no no up up Tyrosine metabolism GnRH secretion -0.590434783 -0.583003953 0 kegg kegg NA NA no no no no up up Ubiquinone and other terpenoid-quinone biosynthesis GnRH secretion -0.546956522 -0.449604743 0 kegg kegg NA NA no no no no up up Ubiquitin mediated proteolysis GnRH secretion 0 0 -0.478507079 kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" GnRH secretion -0.52 -0.558300395 0 kegg kegg NA NA no no no no up up Various types of N-glycan biosynthesis GnRH secretion 0 0 0.405920206 kegg kegg NA NA no no no no up up Vascular smooth muscle contraction GnRH secretion 0 -0.545454545 0 kegg kegg NA NA no no no no up up VEGF signaling pathway GnRH secretion 0.839130435 0.81027668 0.756756757 kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor GnRH secretion 0 0 -0.579150579 kegg kegg NA NA no no no no up up Wnt signaling pathway GnRH secretion 0 0 0.670785071 kegg kegg NA NA no no no no up up 2-Oxocarboxylic acid metabolism GnRH signaling pathway -0.440869565 0 0 kegg kegg NA NA no no no no no no ABC transporters GnRH signaling pathway -0.687826087 0 0 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes GnRH signaling pathway 0.763478261 0.68083004 0.83037323 kegg kegg NA NA no no up no no no alpha-Linolenic acid metabolism GnRH signaling pathway -0.78 0 -0.729214929 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism GnRH signaling pathway -0.565217391 0 -0.628828829 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis GnRH signaling pathway -0.436521739 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway GnRH signaling pathway 0 0.618577075 0 kegg kegg NA NA no no no no no no Antigen processing and presentation GnRH signaling pathway 0 -0.46541502 0 kegg kegg NA NA no no no no no no Apoptosis GnRH signaling pathway -0.472173913 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism GnRH signaling pathway -0.53826087 0 0 kegg kegg NA NA no up no no no no Ascorbate and aldarate metabolism GnRH signaling pathway 0 0 -0.588674389 kegg kegg NA NA no no no no no no beta-Alanine metabolism GnRH signaling pathway -0.560869565 0 -0.504247104 kegg kegg NA NA no no no no no no Biosynthesis of amino acids GnRH signaling pathway -0.537391304 -0.626482213 0 kegg kegg NA NA no no no no no no Butanoate metabolism GnRH signaling pathway -0.493913043 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway GnRH signaling pathway 0.745217391 0.669960474 0.75984556 kegg kegg NA NA no up up no no no cAMP signaling pathway GnRH signaling pathway 0.552173913 0 0.678764479 yes kegg kegg NA NA no up up no no no Carbon metabolism GnRH signaling pathway -0.519130435 -0.666007905 -0.532046332 kegg kegg NA NA no no no no no no Cardiac muscle contraction GnRH signaling pathway 0 0.484189723 0 kegg kegg NA NA no no up no no no Cell adhesion molecules GnRH signaling pathway 0 -0.672924901 0 kegg kegg NA NA no no no no no no Cellular senescence GnRH signaling pathway 0 -0.458498024 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway GnRH signaling pathway 0 -0.482213439 0 kegg kegg NA NA no no no no no no Circadian entrainment GnRH signaling pathway 0.612173913 0.443675889 0.743886744 kegg kegg NA NA no up up no no no Circadian rhythm GnRH signaling pathway 0 0.529644269 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) GnRH signaling pathway -0.422608696 0 -0.413127413 kegg kegg NA NA no no no no no no Clostridium GnRH signaling pathway 0 -0.475782156 0 Genus kegg 0.925 NA no no no no no no Collinsella GnRH signaling pathway 0 -0.450224263 0 Genus kegg 0.128 NA no no no no no no Complement and coagulation cascades GnRH signaling pathway -0.448695652 -0.523715415 0 kegg kegg NA NA no no no no no no Dopaminergic synapse GnRH signaling pathway 0.732173913 0.586956522 0.898326898 kegg kegg NA NA no up no no no no Dorea GnRH signaling pathway -0.467826087 0 0 Genus kegg 0.00362 NA up no dn no no no Drug metabolism - other enzymes GnRH signaling pathway -0.533913043 0 -0.509137709 kegg kegg NA NA no no no no no no ECM-receptor interaction GnRH signaling pathway 0 0 0.445045045 kegg kegg NA NA no up up no no no Endocrine resistance GnRH signaling pathway 0.793043478 0.853754941 0.713256113 kegg kegg NA NA no no no no no no Endocytosis GnRH signaling pathway 0 -0.662055336 0 kegg kegg NA NA no no no no no no Fatty acid degradation GnRH signaling pathway -0.64 0 -0.709395109 kegg kegg NA NA no no no no no no Fatty acid elongation GnRH signaling pathway 0 -0.441699605 0 kegg kegg NA NA no no no no no no Fatty acid metabolism GnRH signaling pathway -0.591304348 -0.461462451 -0.576061776 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis GnRH signaling pathway -0.568695652 -0.636363636 0 kegg kegg NA NA no no no no no no Ferroptosis GnRH signaling pathway 0.526956522 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism GnRH signaling pathway -0.594782609 0 -0.656628057 kegg kegg NA NA no no no no no no Galactose metabolism GnRH signaling pathway -0.630434783 0 -0.614671815 kegg kegg NA NA no no no no no no Gap junction GnRH signaling pathway 0.693043478 0.614624506 0.549034749 kegg kegg NA NA no no no no no no Glutamatergic synapse GnRH signaling pathway 0.715652174 0.421936759 0.515057915 kegg kegg NA NA no up up no no no Glycerolipid metabolism GnRH signaling pathway -0.466956522 0 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" GnRH signaling pathway 0 0.451581028 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis GnRH signaling pathway -0.493043478 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate GnRH signaling pathway 0.549565217 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation GnRH signaling pathway 0 -0.596837945 -0.502960103 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis GnRH signaling pathway 0 0.453557312 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism GnRH signaling pathway -0.486956522 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species GnRH signaling pathway 0 0 -0.407464607 kegg kegg NA NA no no no no no no Histidine metabolism GnRH signaling pathway -0.590434783 0 -0.722779923 kegg kegg NA NA no no no no no no IL-17 signaling pathway GnRH signaling pathway 0 -0.429841897 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels GnRH signaling pathway 0.823478261 0.662055336 0.833976834 kegg kegg NA NA no no no no no no Inositol phosphate metabolism GnRH signaling pathway -0.425217391 0 0 kegg kegg NA NA no no no no no no Insulin secretion GnRH signaling pathway 0.796521739 0.928853755 0.863577864 yes kegg kegg NA NA no up up no no no Long-term depression GnRH signaling pathway 0.811304348 0.660079051 0.778378378 kegg kegg NA NA no no no no no no Long-term potentiation GnRH signaling pathway 0.466086957 0 0 kegg kegg NA NA no no up no no no Longevity regulating pathway GnRH signaling pathway 0.505217391 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species GnRH signaling pathway 0 -0.678853755 0 kegg kegg NA NA no no no no no no Lysosome GnRH signaling pathway 0 -0.612648221 -0.489317889 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 GnRH signaling pathway 0 0 -0.400514801 kegg kegg NA NA no no no no no no Mitophagy - animal GnRH signaling pathway 0.619130435 0.609683794 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway GnRH signaling pathway 0.420869565 0.483201581 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity GnRH signaling pathway 0 -0.531620553 0 kegg kegg NA NA no no no no no no Necroptosis GnRH signaling pathway 0.62173913 0.450592885 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction GnRH signaling pathway -0.506086957 -0.717391304 -0.404890605 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation GnRH signaling pathway -0.488695652 -0.557312253 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway GnRH signaling pathway -0.488695652 0 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism GnRH signaling pathway -0.507826087 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway GnRH signaling pathway -0.623478261 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining GnRH signaling pathway -0.440869565 0 0 kegg kegg NA NA no no no no no no Odoribacter GnRH signaling pathway 0 -0.501239774 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Olfactory transduction GnRH signaling pathway 0 -0.506916996 -0.461003861 kegg kegg NA NA no no no no no no Osteoclast differentiation GnRH signaling pathway -0.62173913 -0.496047431 0 kegg kegg NA NA no no no no no no Other glycan degradation GnRH signaling pathway -0.51826087 0 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis GnRH signaling pathway 0 0.494071146 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation GnRH signaling pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis GnRH signaling pathway -0.455652174 -0.453557312 -0.608494208 kegg kegg NA NA no no dn no no no Paraprevotella GnRH signaling pathway -0.494666023 0 0 Genus kegg 0.118 NA no no no no no no Pentose phosphate pathway GnRH signaling pathway -0.422608696 -0.606719368 -0.459202059 kegg kegg NA NA no no no no no no Peroxisome GnRH signaling pathway -0.593043478 -0.526679842 -0.428828829 kegg kegg NA NA no no no no no no Phagosome GnRH signaling pathway 0 -0.641304348 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism GnRH signaling pathway 0 0 -0.428828829 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system GnRH signaling pathway 0.482608696 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway GnRH signaling pathway 0 -0.451581028 0 kegg kegg NA NA no no no no no no Prevotella GnRH signaling pathway -0.434253932 0 0 Genus kegg 0.367 NA no no no no no no Prevotella GnRH signaling pathway 0 0 0.459723912 acetate-producing Genus kegg 0.287 NA no no no no no no Proteasome GnRH signaling pathway 0 0 -0.452767053 kegg kegg NA NA no no no no no no Pyrimidine metabolism GnRH signaling pathway -0.484347826 0 0 kegg kegg NA NA no no no no no no Renin-angiotensin system GnRH signaling pathway 0 -0.583992095 0 kegg kegg NA NA no no no no no no Retinol metabolism GnRH signaling pathway -0.454782609 0 -0.498326898 kegg kegg NA NA no no no no no no Ribosome GnRH signaling pathway 0.433043478 0.434782609 0 kegg kegg NA NA no no no no no no RNA polymerase GnRH signaling pathway 0 0.420948617 0 kegg kegg NA NA no no no no no no Sarcina GnRH signaling pathway 0 -0.444554224 0 Genus kegg 0.0703 NA no no no no no no Serotonergic synapse GnRH signaling pathway 0.470434783 0 0.444272844 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport GnRH signaling pathway -0.506086957 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism GnRH signaling pathway 0 0 -0.51016731 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway GnRH signaling pathway 0 -0.427865613 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism GnRH signaling pathway -0.710434783 0 -0.683912484 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis GnRH signaling pathway 0 0 -0.463063063 kegg kegg NA NA no no no no no no Synaptic vesicle cycle GnRH signaling pathway 0 -0.588932806 -0.618790219 kegg kegg NA NA no up up no no no Thermogenesis GnRH signaling pathway 0 0.482213439 0 kegg kegg NA NA no no no no no no Tryptophan metabolism GnRH signaling pathway -0.550434783 0 -0.42985843 kegg kegg NA NA no up no no no no Ubiquinone and other terpenoid-quinone biosynthesis GnRH signaling pathway -0.462608696 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis GnRH signaling pathway 0.645217391 0.623517787 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" GnRH signaling pathway -0.463478261 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction GnRH signaling pathway 0.690434783 0.43972332 0.761132561 kegg kegg NA NA no no no no no no Wnt signaling pathway GnRH signaling pathway 0.434782609 0 0 kegg kegg NA NA no no no no no no 14:0/16:0-PC+blood GPC+blood 0 -0.56372549 0 serum_phospholipids serum_choline 0.0358 0.00427 no up no no up up 14:0/18:0-PC+blood GPC+blood -0.47518797 0 0 serum_phospholipids serum_choline 0.00289 0.00427 up up no no up up 16:0-LPC+blood GPC+blood 0.497744361 0 0.446153846 serum_phospholipids serum_choline 0.00456 0.00427 up up no no up up 16:0/16:1-PC+blood GPC+blood -0.482706767 0 0 serum_phospholipids serum_choline 0.00283 0.00427 up up no no up up 16:1-LPC+blood GPC+blood 0.580451128 0 0 serum_phospholipids serum_choline 0.0241 0.00427 no up no no up up 18:0-LPC+blood GPC+blood 0 0 0.557606838 serum_phospholipids serum_choline 0.554 0.00427 no no no no up up 18:0-LPE+blood GPC+blood 0 0 0.420854701 serum_phospholipids serum_choline 0.491 0.00427 no no no no up up 18:0/18:0-PS+blood GPC+blood 0 -0.531862745 0 serum_phospholipids serum_choline 0.00617 0.00427 no up no no up up 18:0+blood GPC+blood 0 -0.541666667 0 serum_fattyacid serum_choline 0.344 0.00427 no no no no up up 18:1/18:0-PS+blood GPC+blood 0 -0.534313725 0 serum_phospholipids serum_choline 0.193 0.00427 no no no no up up 18:1/18:1-PG+blood GPC+blood 0 -0.568627451 0 serum_phospholipids serum_choline 0.00352 0.00427 no up up no up up 18:1/18:2-PI+blood GPC+blood 0.497744361 0 0 serum_phospholipids serum_choline 0.0164 0.00427 dn no up no up up 18:2-LPA+blood GPC+blood 0 0.588235294 0 serum_phospholipids serum_choline 0.00684 0.00427 dn no up no up up 20:1-LPA+blood GPC+blood 0.613533835 0 0 serum_phospholipids serum_choline 0.0187 0.00427 dn dn no no up up 24:0+blood GPC+blood 0 0 -0.517948718 serum_fattyacid serum_choline 0.034 0.00427 dn no up no up up 8-HETE+blood GPC+blood 0 0.526960784 0 serum_ARA serum_choline 0.741 0.00427 no no no no up up 9-HODE+blood GPC+blood 0.487218045 0 0 serum_ARA serum_choline 0.297 0.00427 no no no no up up ACA+stool GPC+blood 0 0 0.487119845 stool_bileacids serum_choline 0.417 0.00427 no no no no up up Adipocytokine signaling pathway GPC+blood -0.485964912 0 0 kegg serum_choline NA 0.00427 no no no no up up Alistipes GPC+blood 0 -0.49049672 0 Genus serum_choline 0.0114 0.00427 no up no no up up Betaine+blood GPC+blood 0 0.691176471 0 serum_choline serum_choline 0.857 0.00427 no no no no up up Butyricimonas GPC+blood 0 -0.510474647 0 butyrate-producing Genus serum_choline 0.17 0.00427 no no no no up up C-type lectin receptor signaling pathway GPC+blood 0 0 0.459230769 kegg serum_choline NA 0.00427 no no no no up up Choline+blood GPC+blood 0 0.830882353 0 serum_choline serum_choline 0.0395 0.00427 no up no no up up Clostridium GPC+blood 0.478375363 0 0 Genus serum_choline 0.925 0.00427 no no no no up up Colorectal cancer GPC+blood 0 -0.555882353 0 kegg serum_choline NA 0.00427 no no no no up up Creatinine+blood GPC+blood 0 0.568627451 0 serum_choline serum_choline 0.437 0.00427 no no no no up up Cysteine+blood GPC+blood 0.470676692 0 0 yes serum_aminoacids serum_choline 1.81E-07 0.00427 dn up up no up up d18:1-20:0-SM+blood GPC+blood 0 0 0.411282051 serum_phospholipids serum_choline 0.933 0.00427 no no no no up up DMG+blood GPC+blood 0 0.490196078 0.407179487 serum_choline serum_choline 0.909 0.00427 no no no no up up Gastric cancer GPC+blood 0 -0.505882353 0 kegg serum_choline NA 0.00427 no no no no up up Gemmiger GPC+blood -0.485714286 0 0 butyrate-producing Genus serum_choline 0.595 0.00427 no no no no up up Glioma GPC+blood 0 -0.564705882 0 kegg serum_choline NA 0.00427 no no no no up up Glycine+blood GPC+blood 0 0.536764706 0 serum_aminoacids serum_choline 0.00408 0.00427 dn no up no up up HCA+stool GPC+blood 0 0 -0.467669173 stool_bileacids serum_choline 0.155 0.00427 no no no no up up Hepatitis B GPC+blood 0 0 0.425384615 kegg serum_choline NA 0.00427 no no no no up up Hepatitis C GPC+blood 0 0 0.432307692 kegg serum_choline NA 0.00427 no no no no up up Oscillospira GPC+blood -0.780451128 0 0 LPS-producing Genus serum_choline 0.62 0.00427 no no no no up up Pancreatic cancer GPC+blood 0.459649123 -0.673529412 0 kegg serum_choline NA 0.00427 no no no no up up Phosphatidylinositol signaling system GPC+blood 0 -0.652941176 0 kegg serum_choline NA 0.00427 no no no no up up Platinum drug resistance GPC+blood 0 -0.502941176 0 kegg serum_choline NA 0.00427 no no no no up up Ras signaling pathway GPC+blood 0.605263158 0 0 yes kegg serum_choline NA 0.00427 no up up no up up RIG-I-like receptor signaling pathway GPC+blood 0 0 0.494615385 kegg serum_choline NA 0.00427 no no no no up up Signaling pathways regulating pluripotency of stem cells GPC+blood 0 -0.505882353 0 kegg serum_choline NA 0.00427 no no no no up up Transcriptional misregulation in cancer GPC+blood 0 0 0.41 kegg serum_choline NA 0.00427 no no no no up up 2-Oxocarboxylic acid metabolism Graft-versus-host disease 0.48173913 0 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Graft-versus-host disease 0 -0.43972332 0 kegg kegg NA NA no no up no no no Aldosterone synthesis and secretion Graft-versus-host disease 0 -0.612648221 0 kegg kegg NA NA no up up no no no Allograft rejection Graft-versus-host disease 0.99826087 1 0.996911197 kegg kegg NA NA no no no no no no Alzheimer disease Graft-versus-host disease -0.510434783 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Graft-versus-host disease 0 0 -0.416216216 kegg kegg NA NA no no no no no no Amphetamine addiction Graft-versus-host disease -0.423478261 -0.684782609 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Graft-versus-host disease 0 -0.665019763 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Graft-versus-host disease -0.456521739 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Graft-versus-host disease 0 0 -0.465122265 kegg kegg NA NA no no no no no no Antigen processing and presentation Graft-versus-host disease 0.493913043 0.533596838 0.662033462 kegg kegg NA NA no no no no no no Apelin signaling pathway Graft-versus-host disease -0.447826087 0 0 kegg kegg NA NA no no no no no no Apoptosis Graft-versus-host disease 0 0.710474308 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Graft-versus-host disease 0 0 -0.563191763 kegg kegg NA NA no no no no no no Asthma Graft-versus-host disease 0.462608696 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Graft-versus-host disease 0.99826087 1 0.996911197 kegg kegg NA NA no no no no no no Autophagy - other Graft-versus-host disease -0.574782609 0 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Graft-versus-host disease 0 0.472332016 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Graft-versus-host disease 0.411304348 0 0 kegg kegg NA NA no no no no no no Bacteroides Graft-versus-host disease 0.420869565 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Graft-versus-host disease -0.580869565 -0.584980237 -0.527670528 kegg kegg NA NA no no no no no no Base excision repair Graft-versus-host disease 0 -0.530632411 -0.427027027 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Graft-versus-host disease 0.574782609 0.587944664 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Graft-versus-host disease 0 -0.843873518 0 kegg kegg NA NA no no no no no no Butyricicoccus Graft-versus-host disease 0 0 0.496522035 butyrate-producing Genus kegg 0.852 NA no no no no no no C-type lectin receptor signaling pathway Graft-versus-host disease 0 0.523715415 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Graft-versus-host disease -0.453913043 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Graft-versus-host disease 0.495652174 0.475296443 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Graft-versus-host disease -0.432173913 0 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Graft-versus-host disease 0.959130435 0.960474308 0.949292149 kegg kegg NA NA no no no no no no Cell cycle Graft-versus-host disease -0.589565217 -0.612648221 0 kegg kegg NA NA no no no no no no Cellular senescence Graft-versus-host disease 0.825217391 0.935770751 0.888803089 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Graft-versus-host disease 0 0 -0.438610039 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Graft-versus-host disease 0 0.528656126 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Graft-versus-host disease -0.54173913 -0.588932806 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Graft-versus-host disease 0 0.451581028 0.475160875 kegg kegg NA NA no no no no no no Cholesterol metabolism Graft-versus-host disease 0 0.708498024 0 yes kegg kegg NA NA no no up no no no Circadian rhythm Graft-versus-host disease -0.497391304 -0.504940711 0 kegg kegg NA NA no no no no no no Cocaine addiction Graft-versus-host disease 0 -0.522727273 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Graft-versus-host disease 0.52 0.57312253 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Graft-versus-host disease 0 -0.627470356 0 kegg kegg NA NA no no up no no no Cushing syndrome Graft-versus-host disease 0 -0.698616601 0 kegg kegg NA NA no no up no no no Cytosolic DNA-sensing pathway Graft-versus-host disease 0 0 0.485199485 kegg kegg NA NA no no no no no no DNA replication Graft-versus-host disease 0 -0.418972332 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Graft-versus-host disease -0.436521739 -0.524703557 0 kegg kegg NA NA no up no no no no Endocrine and other factor-regulated calcium reabsorption Graft-versus-host disease 0 -0.468379447 0 kegg kegg NA NA no no no no no no Endocrine resistance Graft-versus-host disease 0 -0.563241107 0 kegg kegg NA NA no no no no no no Endocytosis Graft-versus-host disease 0.827826087 0.944664032 0.909137709 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Graft-versus-host disease 0 0.577075099 0.547232947 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Graft-versus-host disease 0.496521739 0.544466403 0.746460746 kegg kegg NA NA no no no no no no Estrogen signaling pathway Graft-versus-host disease -0.407826087 -0.490118577 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Graft-versus-host disease -0.502608696 -0.698616601 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Graft-versus-host disease 0 -0.563241107 -0.457657658 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Graft-versus-host disease 0 0.576086957 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Graft-versus-host disease 0 0.546442688 0 kegg kegg NA NA no no no no no no Focal adhesion Graft-versus-host disease 0.405217391 0 0 kegg kegg NA NA no up up no no no Folate biosynthesis Graft-versus-host disease -0.451304348 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Graft-versus-host disease 0 0 -0.529214929 kegg kegg NA NA no no no no no no Glucagon signaling pathway Graft-versus-host disease 0 -0.62944664 0 kegg kegg NA NA no no no no no no Glutathione metabolism Graft-versus-host disease 0 -0.540513834 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Graft-versus-host disease -0.513043478 -0.472332016 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Graft-versus-host disease 0 -0.780632411 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Graft-versus-host disease 0.443478261 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Graft-versus-host disease 0 0.624505929 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Graft-versus-host disease 0 -0.752964427 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Graft-versus-host disease 0 -0.553359684 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Graft-versus-host disease 0 -0.446640316 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Graft-versus-host disease 0.428695652 0.53458498 0.702702703 kegg kegg NA NA no no no no no no Homologous recombination Graft-versus-host disease 0 -0.505928854 -0.530501931 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Graft-versus-host disease 0.443478261 0.535573123 0.694465894 kegg kegg NA NA no no dn no no no Human immunodeficiency virus 1 infection Graft-versus-host disease 0 0.53458498 0.675418275 kegg kegg NA NA no no no no no no Human papillomavirus infection Graft-versus-host disease 0.833913043 0.90513834 0.83989704 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Graft-versus-host disease 0.494782609 0.519762846 0.727927928 kegg kegg NA NA no no no no no no Huntington disease Graft-versus-host disease -0.479130435 0 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Graft-versus-host disease 0 0.563241107 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Graft-versus-host disease 0 -0.421936759 0 kegg kegg NA NA no no no no no no Influenza A Graft-versus-host disease 0.604347826 0.770750988 0.543371943 kegg kegg NA NA no no no no no no Insulin resistance Graft-versus-host disease -0.482608696 0 0 kegg kegg NA NA no no no no no no Insulin secretion Graft-versus-host disease 0 -0.570158103 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Graft-versus-host disease -0.443478261 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Graft-versus-host disease 0.52 0.506916996 0.435521236 kegg kegg NA NA no no no no no no Long-term potentiation Graft-versus-host disease -0.455652174 0 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Graft-versus-host disease 0 -0.471343874 0 kegg kegg NA NA no no no no no no Lysosome Graft-versus-host disease 0 0.704545455 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Graft-versus-host disease -0.6 0 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Graft-versus-host disease 0 -0.513833992 0 kegg kegg NA NA no up no no no no Measles Graft-versus-host disease -0.507826087 0 0 kegg kegg NA NA no no no no no no Mismatch repair Graft-versus-host disease 0 -0.545454545 0 kegg kegg NA NA no no no no no no Mitophagy - animal Graft-versus-host disease 0 -0.491106719 0 kegg kegg NA NA no no no no no no Morphine addiction Graft-versus-host disease 0 -0.428853755 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Graft-versus-host disease -0.593913043 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Graft-versus-host disease 0.825217391 0.95256917 0.908880309 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Graft-versus-host disease 0 0.615612648 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Graft-versus-host disease 0 0.492094862 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Graft-versus-host disease 0 0.612648221 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Graft-versus-host disease 0 0.490118577 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Graft-versus-host disease -0.509565217 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Graft-versus-host disease 0 -0.589920949 -0.526126126 kegg kegg NA NA no no no no no no One carbon pool by folate Graft-versus-host disease 0 -0.546442688 0 kegg kegg NA NA no no no no no no Oocyte meiosis Graft-versus-host disease -0.513043478 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Graft-versus-host disease 0 0.588932806 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Graft-versus-host disease -0.544347826 -0.53458498 -0.41029601 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Graft-versus-host disease 0 -0.457509881 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Graft-versus-host disease -0.463478261 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Graft-versus-host disease -0.519130435 -0.491106719 -0.562419562 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Graft-versus-host disease -0.414782609 -0.434782609 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Graft-versus-host disease 0 0.7756917 0.482110682 kegg kegg NA NA no no no no no no Pathways in cancer Graft-versus-host disease -0.564347826 0 -0.442213642 kegg kegg NA NA no no no no no no Pentose phosphate pathway Graft-versus-host disease 0.443478261 0.663043478 0 kegg kegg NA NA no no no no no no Pertussis Graft-versus-host disease 0 0.649209486 0 kegg kegg NA NA no no dn no no no Phagosome Graft-versus-host disease 0.890434783 0.916007905 0.818018018 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Graft-versus-host disease -0.540869565 0 0 yes kegg kegg NA NA no up up no no no Platinum drug resistance Graft-versus-host disease 0 0 -0.577091377 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Graft-versus-host disease 0 -0.745059289 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Graft-versus-host disease 0 0.457509881 0 kegg kegg NA NA no no no no no no Prion disease Graft-versus-host disease -0.456521739 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Graft-versus-host disease -0.428695652 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Graft-versus-host disease 0 0.455533597 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Graft-versus-host disease 0.419130435 0.456521739 0 yes kegg kegg NA NA no up up no no no Protein export Graft-versus-host disease -0.535652174 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Graft-versus-host disease 0 -0.471343874 0 kegg kegg NA NA no no no no no no Purine metabolism Graft-versus-host disease 0 -0.751976285 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Graft-versus-host disease 0 -0.423913043 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Graft-versus-host disease 0 -0.431818182 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Graft-versus-host disease 0 0.677865613 0 kegg kegg NA NA no no no no no no Retinol metabolism Graft-versus-host disease 0 -0.414031621 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Graft-versus-host disease -0.51826087 0 0 kegg kegg NA NA no no up no no no Rheumatoid arthritis Graft-versus-host disease 0.66 0.739130435 0.428828829 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Graft-versus-host disease -0.424347826 -0.536561265 0 kegg kegg NA NA no no no no no no RNA degradation Graft-versus-host disease -0.494782609 0 0 kegg kegg NA NA no no no no no no RNA polymerase Graft-versus-host disease -0.453043478 -0.570158103 0 kegg kegg NA NA no no no no no no Ruminococcus Graft-versus-host disease 0 0 0.412612613 acetate-producing Genus kegg 0.335 NA no no no no no no Salmonella infection Graft-versus-host disease 0 0.706521739 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Graft-versus-host disease -0.545217391 -0.531620553 -0.474388674 kegg kegg NA NA no no no no no no Sphingolipid metabolism Graft-versus-host disease 0 0.445652174 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Graft-versus-host disease 0 0.713438735 0 kegg kegg NA NA no no no no no no Spliceosome Graft-versus-host disease -0.410434783 0 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Graft-versus-host disease 0.580869565 0.731225296 0 kegg kegg NA NA up no no no no no Steroid biosynthesis Graft-versus-host disease -0.587826087 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Graft-versus-host disease 0 0.462450593 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Graft-versus-host disease 0 -0.589920949 -0.40978121 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Graft-versus-host disease 0.414782609 0.687747036 0 kegg kegg NA NA no no no no no no Taste transduction Graft-versus-host disease -0.649565217 -0.586956522 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Graft-versus-host disease -0.435652174 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Graft-versus-host disease -0.676521739 0 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Graft-versus-host disease 0 0.570158103 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Graft-versus-host disease 0 0.540513834 0 kegg kegg NA NA no no no no no no Thermogenesis Graft-versus-host disease -0.439130435 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Graft-versus-host disease 0 -0.592885375 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Graft-versus-host disease 0 -0.496047431 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Graft-versus-host disease 0 0.48715415 0.463835264 yes kegg kegg NA NA no no no no no no Toxoplasmosis Graft-versus-host disease 0 0.563241107 0 kegg kegg NA NA no no no no no no Tuberculosis Graft-versus-host disease 0.480869565 0.698616601 0 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Graft-versus-host disease 0.99826087 0.999011858 0.996911197 kegg kegg NA NA no no no no no no Tyrosine metabolism Graft-versus-host disease 0 -0.449604743 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Graft-versus-host disease 0 -0.449604743 -0.414671815 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Graft-versus-host disease 0 -0.555335968 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Graft-versus-host disease 0 -0.425889328 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Graft-versus-host disease 0.790434783 0.916996047 0.851994852 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Graft-versus-host disease -0.553913043 0 0 kegg kegg NA NA no no no no no no Yersinia infection Graft-versus-host disease 0 0.713438735 0.408236808 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism "Growth hormone synthesis, secretion and action" -0.504347826 -0.463438735 -0.557786358 kegg kegg NA NA no no no no no no ABC transporters "Growth hormone synthesis, secretion and action" 0 0.519762846 0 kegg kegg NA NA no up up no no no Adherens junction "Growth hormone synthesis, secretion and action" 0 -0.436758893 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway "Growth hormone synthesis, secretion and action" 0 0.43083004 0.509395109 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes "Growth hormone synthesis, secretion and action" 0.448695652 0 0.436036036 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications "Growth hormone synthesis, secretion and action" 0 0.414031621 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion "Growth hormone synthesis, secretion and action" 0.511304348 0 0.538738739 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism "Growth hormone synthesis, secretion and action" -0.5 0 -0.587902188 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism "Growth hormone synthesis, secretion and action" -0.526086957 0 -0.438867439 kegg kegg NA NA no no no no no no Antigen processing and presentation "Growth hormone synthesis, secretion and action" -0.508695652 -0.659090909 0 kegg kegg NA NA no no no no no no Apelin signaling pathway "Growth hormone synthesis, secretion and action" 0 -0.453557312 -0.468725869 kegg kegg NA NA no no no no no no Apoptosis - multiple species "Growth hormone synthesis, secretion and action" 0 0.429841897 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism "Growth hormone synthesis, secretion and action" -0.465217391 0 -0.572972973 kegg kegg NA NA no no no no no no Autophagy - animal "Growth hormone synthesis, secretion and action" 0 0.511857708 0 kegg kegg NA NA no no no no no no Bacteroides "Growth hormone synthesis, secretion and action" 0 -0.493083004 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no beta-Alanine metabolism "Growth hormone synthesis, secretion and action" -0.56 -0.646245059 -0.663835264 kegg kegg NA NA no no no no no no Biosynthesis of amino acids "Growth hormone synthesis, secretion and action" -0.452173913 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids "Growth hormone synthesis, secretion and action" -0.456521739 -0.571146245 -0.586872587 kegg kegg NA NA no no no no no no Butanoate metabolism "Growth hormone synthesis, secretion and action" -0.626086957 -0.596837945 -0.700900901 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway "Growth hormone synthesis, secretion and action" 0 0 0.417245817 kegg kegg NA NA no no no no no no Calcium signaling pathway "Growth hormone synthesis, secretion and action" 0.485217391 0 0.557786358 kegg kegg NA NA no up up no no no cAMP signaling pathway "Growth hormone synthesis, secretion and action" 0.524347826 0.455533597 0.763706564 yes kegg kegg NA NA no up up no no no Carbon metabolism "Growth hormone synthesis, secretion and action" -0.597391304 -0.746047431 -0.45045045 kegg kegg NA NA no no no no no no Cholinergic synapse "Growth hormone synthesis, secretion and action" 0.577391304 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) "Growth hormone synthesis, secretion and action" -0.620869565 -0.713438735 -0.655855856 kegg kegg NA NA no no no no no no Clostridium "Growth hormone synthesis, secretion and action" 0 -0.698900555 0 Genus kegg 0.925 NA no no no no no no Cortisol synthesis and secretion "Growth hormone synthesis, secretion and action" 0.633913043 0.638339921 0.727155727 kegg kegg NA NA no no up no no no Cushing syndrome "Growth hormone synthesis, secretion and action" 0.519130435 0.545454545 0.676962677 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism "Growth hormone synthesis, secretion and action" -0.424347826 -0.615612648 0 kegg kegg NA NA no no no no no no DNA replication "Growth hormone synthesis, secretion and action" 0 0 -0.484427284 kegg kegg NA NA no no no no no no Dopaminergic synapse "Growth hormone synthesis, secretion and action" 0.460869565 0 0.510939511 kegg kegg NA NA no up no no no no Dorea "Growth hormone synthesis, secretion and action" -0.470434783 0 0 Genus kegg 0.00362 NA up no dn no no no Drug metabolism - cytochrome P450 "Growth hormone synthesis, secretion and action" -0.55826087 -0.58201581 -0.678764479 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes "Growth hormone synthesis, secretion and action" -0.729565217 -0.670948617 -0.514800515 kegg kegg NA NA no no no no no no Endocrine resistance "Growth hormone synthesis, secretion and action" 0.80173913 0.7756917 0.843500644 kegg kegg NA NA no no no no no no ErbB signaling pathway "Growth hormone synthesis, secretion and action" 0.702608696 0.688735178 0 kegg kegg NA NA no no no no no no Fatty acid degradation "Growth hormone synthesis, secretion and action" 0 0 -0.571943372 kegg kegg NA NA no no no no no no Fatty acid elongation "Growth hormone synthesis, secretion and action" -0.633913043 -0.752964427 -0.704761905 kegg kegg NA NA no no no no no no Fatty acid metabolism "Growth hormone synthesis, secretion and action" 0 0 -0.544401544 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway "Growth hormone synthesis, secretion and action" 0.589565217 0 0 kegg kegg NA NA no no no no no no Ferroptosis "Growth hormone synthesis, secretion and action" 0 0.428853755 0 kegg kegg NA NA no no no no no no Focal adhesion "Growth hormone synthesis, secretion and action" 0 -0.583003953 0 kegg kegg NA NA no up up no no no FoxO signaling pathway "Growth hormone synthesis, secretion and action" 0 0.530632411 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism "Growth hormone synthesis, secretion and action" 0 0.5256917 0 kegg kegg NA NA no no no no no no Gap junction "Growth hormone synthesis, secretion and action" 0 0.694664032 0.508622909 kegg kegg NA NA no no no no no no Glutamatergic synapse "Growth hormone synthesis, secretion and action" 0.517391304 0.710474308 0.523294723 kegg kegg NA NA no up up no no no Glycerolipid metabolism "Growth hormone synthesis, secretion and action" 0 0.56916996 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism "Growth hormone synthesis, secretion and action" 0 0.598814229 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" "Growth hormone synthesis, secretion and action" 0 0 0.416731017 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis "Growth hormone synthesis, secretion and action" -0.59826087 -0.813241107 -0.508365508 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate "Growth hormone synthesis, secretion and action" 0 0.678853755 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin "Growth hormone synthesis, secretion and action" -0.503478261 0 0 kegg kegg NA NA no no no no no no GnRH secretion "Growth hormone synthesis, secretion and action" 0.753913043 0.759881423 0 kegg kegg NA NA no up up no no no GnRH signaling pathway "Growth hormone synthesis, secretion and action" 0.619130435 0.605731225 0.628571429 kegg kegg NA NA no no no no no no Hedgehog signaling pathway "Growth hormone synthesis, secretion and action" 0.508695652 0 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage "Growth hormone synthesis, secretion and action" 0 -0.678853755 -0.41956242 kegg kegg NA NA no no no no no no HIF-1 signaling pathway "Growth hormone synthesis, secretion and action" 0 -0.535573123 0 kegg kegg NA NA no no no no no no Hippo signaling pathway "Growth hormone synthesis, secretion and action" 0 -0.45256917 0 kegg kegg NA NA no no no no no no Histidine metabolism "Growth hormone synthesis, secretion and action" -0.422608696 0 -0.503217503 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels "Growth hormone synthesis, secretion and action" 0.446956522 0 0.511454311 kegg kegg NA NA no no no no no no Inositol phosphate metabolism "Growth hormone synthesis, secretion and action" 0 0.500988142 0 kegg kegg NA NA no no no no no no Insulin resistance "Growth hormone synthesis, secretion and action" 0 0.567193676 0 kegg kegg NA NA no no no no no no Insulin secretion "Growth hormone synthesis, secretion and action" 0.611304348 0.561264822 0.733075933 yes kegg kegg NA NA no up up no no no Insulin signaling pathway "Growth hormone synthesis, secretion and action" 0 -0.458498024 -0.462805663 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway "Growth hormone synthesis, secretion and action" 0 0.592885375 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration "Growth hormone synthesis, secretion and action" 0 -0.497035573 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism "Growth hormone synthesis, secretion and action" -0.62 0 0 kegg kegg NA NA no no no no no no Long-term depression "Growth hormone synthesis, secretion and action" 0.555652174 0.639328063 0.735392535 kegg kegg NA NA no no no no no no Long-term potentiation "Growth hormone synthesis, secretion and action" 0 -0.609683794 0 kegg kegg NA NA no no up no no no Longevity regulating pathway "Growth hormone synthesis, secretion and action" 0.614782609 0.532608696 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species "Growth hormone synthesis, secretion and action" 0 -0.56027668 -0.407722008 kegg kegg NA NA no no no no no no Melanogenesis "Growth hormone synthesis, secretion and action" 0 0 0.493951094 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 "Growth hormone synthesis, secretion and action" -0.6 -0.650197628 -0.697554698 kegg kegg NA NA no no no no no no Mismatch repair "Growth hormone synthesis, secretion and action" -0.535652174 -0.415019763 -0.553153153 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis "Growth hormone synthesis, secretion and action" -0.41826087 0 0 kegg kegg NA NA no no no no no no Necroptosis "Growth hormone synthesis, secretion and action" 0.424347826 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction "Growth hormone synthesis, secretion and action" -0.544347826 0 0 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway "Growth hormone synthesis, secretion and action" 0 0.469367589 0.50965251 kegg kegg NA NA no no no no no no Non-homologous end-joining "Growth hormone synthesis, secretion and action" -0.543478261 -0.731225296 -0.500643501 kegg kegg NA NA no no no no no no Notch signaling pathway "Growth hormone synthesis, secretion and action" 0 0.708498024 0 kegg kegg NA NA no no no no no no Nucleotide excision repair "Growth hormone synthesis, secretion and action" 0 0 -0.447361647 kegg kegg NA NA no no no no no no Odoribacter "Growth hormone synthesis, secretion and action" 0 -0.569095356 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Oocyte meiosis "Growth hormone synthesis, secretion and action" 0 -0.729249012 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis "Growth hormone synthesis, secretion and action" 0 0.532608696 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis "Growth hormone synthesis, secretion and action" 0 0.572134387 0.564736165 kegg kegg NA NA no up up no no no p53 signaling pathway "Growth hormone synthesis, secretion and action" 0 0.555335968 0 kegg kegg NA NA no no no no no no Paraprevotella "Growth hormone synthesis, secretion and action" -0.595152643 0 0 Genus kegg 0.118 NA no no no no no no "Parathyroid hormone synthesis, secretion and action" "Growth hormone synthesis, secretion and action" 0 0 0.447104247 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions "Growth hormone synthesis, secretion and action" -0.675652174 -0.548418972 -0.557528958 kegg kegg NA NA no no no no no no Phenylalanine metabolism "Growth hormone synthesis, secretion and action" -0.470434783 -0.549407115 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system "Growth hormone synthesis, secretion and action" 0.450434783 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway "Growth hormone synthesis, secretion and action" 0.522608696 0.749011858 0.720720721 kegg kegg NA NA no up up no no no Phototransduction "Growth hormone synthesis, secretion and action" 0 -0.769762846 -0.448133848 kegg kegg NA NA no no no no no no Platinum drug resistance "Growth hormone synthesis, secretion and action" 0 0.431818182 0 kegg kegg NA NA no no no no no no Prevotella "Growth hormone synthesis, secretion and action" -0.411589322 0 0 Genus kegg 0.367 NA no no no no no no Prevotella "Growth hormone synthesis, secretion and action" 0 0.632678199 0.467781804 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis "Growth hormone synthesis, secretion and action" -0.564347826 -0.745059289 -0.477220077 kegg kegg NA NA no no no no no no Prolactin signaling pathway "Growth hormone synthesis, secretion and action" 0.720869565 0.497035573 0.526383526 kegg kegg NA NA no no no no no no Propanoate metabolism "Growth hormone synthesis, secretion and action" -0.49826087 -0.641304348 -0.433204633 kegg kegg NA NA no no no no no no Proteasome "Growth hormone synthesis, secretion and action" 0 -0.824110672 -0.604375804 kegg kegg NA NA no no no no no no Protein export "Growth hormone synthesis, secretion and action" 0 -0.552371542 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism "Growth hormone synthesis, secretion and action" -0.463478261 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism "Growth hormone synthesis, secretion and action" -0.47826087 -0.563241107 -0.420849421 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton "Growth hormone synthesis, secretion and action" -0.549565217 -0.727272727 -0.507078507 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes "Growth hormone synthesis, secretion and action" 0.571304348 0.614624506 0.623166023 kegg kegg NA NA no no no no no no Relaxin signaling pathway "Growth hormone synthesis, secretion and action" 0.564347826 0.613636364 0.748519949 kegg kegg NA NA no no no no no no Renin-angiotensin system "Growth hormone synthesis, secretion and action" -0.413913043 0 0 kegg kegg NA NA no no no no no no Retinol metabolism "Growth hormone synthesis, secretion and action" -0.506956522 0 -0.641184041 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway "Growth hormone synthesis, secretion and action" 0 0 0.517374517 kegg kegg NA NA no no no no no no RNA polymerase "Growth hormone synthesis, secretion and action" 0 0 -0.452767053 kegg kegg NA NA no no no no no no RNA transport "Growth hormone synthesis, secretion and action" 0 -0.451581028 0 kegg kegg NA NA no no no no no no Serotonergic synapse "Growth hormone synthesis, secretion and action" 0 0.503952569 0.538481338 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells "Growth hormone synthesis, secretion and action" 0.612173913 0.572134387 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway "Growth hormone synthesis, secretion and action" 0.473043478 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis "Growth hormone synthesis, secretion and action" 0 -0.420948617 -0.490604891 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis "Growth hormone synthesis, secretion and action" -0.631304348 0 -0.462290862 kegg kegg NA NA no no no no no no Sulfur metabolism "Growth hormone synthesis, secretion and action" 0 -0.429841897 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies "Growth hormone synthesis, secretion and action" 0 0 -0.445045045 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism "Growth hormone synthesis, secretion and action" 0.448695652 0.792490119 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway "Growth hormone synthesis, secretion and action" 0 -0.514822134 0 kegg kegg NA NA no no no no no no Thiamine metabolism "Growth hormone synthesis, secretion and action" -0.439130435 -0.504940711 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis "Growth hormone synthesis, secretion and action" 0 0 0.431145431 kegg kegg NA NA no no no no no no Tight junction "Growth hormone synthesis, secretion and action" 0 -0.627470356 -0.432947233 kegg kegg NA NA no no no no no no TNF signaling pathway "Growth hormone synthesis, secretion and action" 0.488695652 0.45256917 0.497297297 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway "Growth hormone synthesis, secretion and action" 0.406956522 0 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism "Growth hormone synthesis, secretion and action" -0.640869565 -0.713438735 -0.684684685 kegg kegg NA NA no up no no no no Type II diabetes mellitus "Growth hormone synthesis, secretion and action" 0.617391304 0.697628458 0 kegg kegg NA NA no no no no no no Tyrosine metabolism "Growth hormone synthesis, secretion and action" -0.450434783 0 -0.575804376 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis "Growth hormone synthesis, secretion and action" -0.567826087 0 -0.467953668 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" "Growth hormone synthesis, secretion and action" -0.582608696 -0.480237154 -0.722265122 kegg kegg NA NA no no no no no no VEGF signaling pathway "Growth hormone synthesis, secretion and action" 0.593043478 0.47826087 0 kegg kegg NA NA no no no no no no 11-HETE+blood GUDCA+blood 0 0.493276281 0 serum_ARA serum_bileacids 0.464 0.0766 no no no no no dn 12-ketoDCA+stool GUDCA+blood 0 0 -0.461654135 stool_bileacids serum_bileacids 0.505 0.0766 no no no no no dn 16:0/16:0-PC+blood GUDCA+blood -0.694736842 0 0 serum_phospholipids serum_bileacids 0.00079 0.0766 no up up no no dn 16:0/16:1-PC+blood GUDCA+blood 0 0.507352941 0 serum_phospholipids serum_bileacids 0.00283 0.0766 up up no no no dn 16:0/16:1-PI+blood GUDCA+blood 0.47518797 0 0 serum_phospholipids serum_bileacids 0.262 0.0766 no no no no no dn 16:0/18:0-PC+blood GUDCA+blood 0 0 -0.431794872 serum_phospholipids serum_bileacids 0.521 0.0766 no no no no no dn 16:0/18:1-PC+blood GUDCA+blood -0.476691729 0 0 serum_phospholipids serum_bileacids 6.15E-07 0.0766 up up up no no dn 16:0/18:2-PC+blood GUDCA+blood -0.457142857 0 0 serum_phospholipids serum_bileacids 3.24E-06 0.0766 no up up no no dn 16:0/22:6-PC+blood GUDCA+blood -0.536842105 0 0 serum_phospholipids serum_bileacids 4.53E-05 0.0766 no up up no no dn 16:1/16:0-PC+blood GUDCA+blood -0.511278195 0 0 serum_phospholipids serum_bileacids 0.0215 0.0766 no up up no no dn 16:1/16:1-PC+blood GUDCA+blood -0.598496241 0 0 serum_phospholipids serum_bileacids 0.0177 0.0766 no no up no no dn 16:1/18:2-PG+blood GUDCA+blood -0.545864662 0 0 serum_phospholipids serum_bileacids 1.40E-08 0.0766 no up up no no dn 18:0/16:0-PC+blood GUDCA+blood -0.494736842 0 0 serum_phospholipids serum_bileacids 9.64E-07 0.0766 up up up no no dn 18:0/18:0-PC+blood GUDCA+blood 0 0.512254902 0 serum_phospholipids serum_bileacids 0.426 0.0766 no no no no no dn 18:0/18:0-PE+blood GUDCA+blood 0 0 -0.482393162 serum_phospholipids serum_bileacids 0.00896 0.0766 up up no no no dn 18:0/18:1-PC+blood GUDCA+blood 0 0.56127451 0 serum_phospholipids serum_bileacids 0.393 0.0766 no no no no no dn 18:0/18:1-PE+blood GUDCA+blood 0 0 -0.411965812 serum_phospholipids serum_bileacids 0.00716 0.0766 up up no no no dn 18:0/18:2-PC+blood GUDCA+blood -0.556390977 0 0 serum_phospholipids serum_bileacids 1.74E-06 0.0766 no up up no no dn 18:0/20:4-PC+blood GUDCA+blood -0.44962406 0 0 serum_phospholipids serum_bileacids 0.454 0.0766 no no no no no dn 18:1/16:0-PC+blood GUDCA+blood -0.520300752 0 0 serum_phospholipids serum_bileacids 2.43E-05 0.0766 no up up no no dn 18:1/18:0-PC+blood GUDCA+blood -0.630075188 0 0 serum_phospholipids serum_bileacids 1.83E-06 0.0766 no up up no no dn 18:1/18:0-PS+blood GUDCA+blood -0.610526316 0 0 serum_phospholipids serum_bileacids 0.193 0.0766 no no no no no dn 18:1/18:2-PG+blood GUDCA+blood -0.520300752 0 0 serum_phospholipids serum_bileacids 5.58E-07 0.0766 no up up no no dn 18:1/20:4-PI+blood GUDCA+blood 0 -0.632352941 0 serum_phospholipids serum_bileacids 0.192 0.0766 no no no no no dn 18:2/16:0-PC+blood GUDCA+blood -0.618045113 0 0 serum_phospholipids serum_bileacids 8.67E-05 0.0766 no up up no no dn 18:3n3+blood GUDCA+blood -0.493233083 0 0 serum_fattyacid serum_bileacids 0.291 0.0766 no no no no no dn 20:0-LPC+blood GUDCA+blood 0.506766917 0 0 serum_phospholipids serum_bileacids 0.199 0.0766 no no no no no dn 20:0/20:5-PC+blood GUDCA+blood -0.446616541 0 0 serum_phospholipids serum_bileacids 0.882 0.0766 no no no no no dn 20:3/18:0-PC+blood GUDCA+blood -0.49924812 0 0 serum_phospholipids serum_bileacids 0.296 0.0766 no no no no no dn 20:4-LPA+blood GUDCA+blood -0.563909774 0 0 serum_phospholipids serum_bileacids 0.398 0.0766 no no no no no dn 20:5/18:0-PC+blood GUDCA+blood -0.446616541 0 0 serum_phospholipids serum_bileacids 3.97E-06 0.0766 no up up no no dn AA+blood GUDCA+blood -0.673684211 0 0 serum_ARA serum_bileacids 0.212 0.0766 no no no no no dn AGE-RAGE signaling pathway in diabetic complications GUDCA+blood 0 -0.564705882 0 kegg serum_bileacids NA 0.0766 no no no no no dn Alistipes GUDCA+blood 0 0 -0.42024261 Genus serum_bileacids 0.0114 0.0766 no up no no no dn Allograft rejection GUDCA+blood 0 -0.529411765 0 kegg serum_bileacids NA 0.0766 no no no no no dn Alzheimer disease GUDCA+blood 0 0.6 0 kegg serum_bileacids NA 0.0766 no no no no no dn Amphetamine addiction GUDCA+blood 0 0.591176471 0 kegg serum_bileacids NA 0.0766 no no no no no dn Amyotrophic lateral sclerosis GUDCA+blood 0 0.697058824 0 kegg serum_bileacids NA 0.0766 no no no no no dn Apoptosis GUDCA+blood 0 -0.502941176 0 kegg serum_bileacids NA 0.0766 no no no no no dn Arginine and proline metabolism GUDCA+blood 0 -0.514705882 0 kegg serum_bileacids NA 0.0766 no up no no no dn Autoimmune thyroid disease GUDCA+blood 0 -0.529411765 0 kegg serum_bileacids NA 0.0766 no no no no no dn Biosynthesis of amino acids GUDCA+blood 0 -0.570588235 0 kegg serum_bileacids NA 0.0766 no no no no no dn Biosynthesis of cofactors GUDCA+blood 0 0.514705882 0 kegg serum_bileacids NA 0.0766 no no no no no dn Bladder cancer GUDCA+blood 0 -0.508823529 0 kegg serum_bileacids NA 0.0766 no no no no no dn Blautia GUDCA+blood 0 0 0.539625817 acetate-producing Genus serum_bileacids 1.36E-05 0.0766 up dn dn no no dn CA+blood GUDCA+blood 0 0.500306654 0 serum_bileacids serum_bileacids 0.606 0.0766 no no no no no dn Cardiac muscle contraction GUDCA+blood 0 0.526470588 0 kegg serum_bileacids NA 0.0766 no no up no no dn CDCA+blood GUDCA+blood 0.481203008 0.754901961 0 serum_bileacids serum_bileacids 0.506 0.0766 no no no no no dn Cell adhesion molecules GUDCA+blood 0 -0.532352941 0 kegg serum_bileacids NA 0.0766 no no no no no dn Cellular senescence GUDCA+blood 0 -0.608823529 0 kegg serum_bileacids NA 0.0766 no no no no no dn cGMP-PKG signaling pathway GUDCA+blood 0 -0.6 0 kegg serum_bileacids NA 0.0766 no no no no no dn d18:1-18:0-SM+blood GUDCA+blood -0.598496241 0 0 serum_phospholipids serum_bileacids 0.97 0.0766 no no no no no dn d18:1-18:1-SM+blood GUDCA+blood -0.535338346 0 0 serum_phospholipids serum_bileacids 0.916 0.0766 no no no no no dn d18:1-20:1-SM+blood GUDCA+blood -0.470676692 -0.5 0 serum_phospholipids serum_bileacids 0.0992 0.0766 no no no no no dn DCA+blood GUDCA+blood 0.6 0 0 serum_bileacids serum_bileacids 0.122 0.0766 no no no no no dn Diabetic cardiomyopathy GUDCA+blood 0 0.570588235 0 kegg serum_bileacids NA 0.0766 no no no no no dn Endocytosis GUDCA+blood 0 -0.564705882 0 kegg serum_bileacids NA 0.0766 no no no no no dn Epithelial cell signaling in Helicobacter pylori infection GUDCA+blood 0 -0.582352941 0 kegg serum_bileacids NA 0.0766 no no no no no dn Fc epsilon RI signaling pathway GUDCA+blood 0 -0.658823529 0 kegg serum_bileacids NA 0.0766 no no no no no dn Fc gamma R-mediated phagocytosis GUDCA+blood 0 -0.65 0 kegg serum_bileacids NA 0.0766 no no no no no dn Fusobacterium GUDCA+blood 0 -0.539815486 0.408765371 Genus serum_bileacids 0.628 0.0766 no no no no no dn GABAergic synapse GUDCA+blood 0 -0.558823529 0 kegg serum_bileacids NA 0.0766 no up up no no dn GCA+blood GUDCA+blood 0.789473684 0 0.413333333 yes serum_bileacids serum_bileacids 0.16 0.0766 no no no no no dn GCDCA+blood GUDCA+blood 0.840601504 0.772058824 0.701196581 serum_bileacids serum_bileacids 0.31 0.0766 no no no no no dn GPC+blood GUDCA+blood 0 0 -0.494700855 serum_choline serum_bileacids 0.00427 0.0766 no up up no no dn Graft-versus-host disease GUDCA+blood 0 -0.529411765 0 kegg serum_bileacids NA 0.0766 no no no no no dn HCA+stool GUDCA+blood 0 0 0.521804511 stool_bileacids serum_bileacids 0.155 0.0766 no no no no no dn Hepatitis B GUDCA+blood 0 -0.505882353 0 kegg serum_bileacids NA 0.0766 no no no no no dn Hepatitis C GUDCA+blood 0 0 -0.509230769 kegg serum_bileacids NA 0.0766 no no no no no dn Human papillomavirus infection GUDCA+blood 0 -0.594117647 0 kegg serum_bileacids NA 0.0766 no no no no no dn Huntington disease GUDCA+blood 0 0.605882353 0 kegg serum_bileacids NA 0.0766 no no no no no dn IL-17 signaling pathway GUDCA+blood 0 -0.517647059 0 kegg serum_bileacids NA 0.0766 no no no no no dn iso-LCA+stool GUDCA+blood 0 0 -0.446616541 stool_bileacids serum_bileacids 0.72 0.0766 no no no no no dn Lipid and atherosclerosis GUDCA+blood 0 -0.626470588 0 kegg serum_bileacids NA 0.0766 no no no no no dn mRNA surveillance pathway GUDCA+blood 0 0.541176471 0 kegg serum_bileacids NA 0.0766 no no no no no dn Natural killer cell mediated cytotoxicity GUDCA+blood 0 -0.617647059 0 kegg serum_bileacids NA 0.0766 no no no no no dn Neutrophil extracellular trap formation GUDCA+blood 0 -0.576470588 0 kegg serum_bileacids NA 0.0766 no no no no no dn Nicotinate and nicotinamide metabolism GUDCA+blood 0 -0.635294118 0 kegg serum_bileacids NA 0.0766 no no no no no dn NOD-like receptor signaling pathway GUDCA+blood 0 -0.570588235 -0.416153846 kegg serum_bileacids NA 0.0766 no no no no no dn Non-alcoholic fatty liver disease GUDCA+blood 0 0.529411765 0 kegg serum_bileacids NA 0.0766 no no no no no dn nutriCA+stool GUDCA+blood 0 0 0.637593985 stool_bileacids serum_bileacids 0.481 0.0766 no no no no no dn Olfactory transduction GUDCA+blood 0 -0.602941176 0 kegg serum_bileacids NA 0.0766 no no no no no dn Osteoclast differentiation GUDCA+blood 0 -0.614705882 0 kegg serum_bileacids NA 0.0766 no no no no no dn Oxidative phosphorylation GUDCA+blood 0 0.588235294 0 kegg serum_bileacids NA 0.0766 no no no no no dn Parkinson disease GUDCA+blood 0 0.558823529 0 kegg serum_bileacids NA 0.0766 no no no no no dn Pathogenic Escherichia coli infection GUDCA+blood 0 -0.552941176 0 kegg serum_bileacids NA 0.0766 no no no no no dn Pathways of neurodegeneration - multiple diseases GUDCA+blood 0 0.594117647 0 kegg serum_bileacids NA 0.0766 no no no no no dn Pertussis GUDCA+blood 0 -0.538235294 0 kegg serum_bileacids NA 0.0766 no no dn no no dn Phagosome GUDCA+blood 0 -0.591176471 0 kegg serum_bileacids NA 0.0766 no no no no no dn Phenylacetic acid+stool GUDCA+blood 0 -0.618181818 0 stool_cometabolism serum_bileacids 0.785 0.0766 no no no no no dn Phospholipase D signaling pathway GUDCA+blood 0 -0.555882353 0 kegg serum_bileacids NA 0.0766 no up up no no dn Porphyrin and chlorophyll metabolism GUDCA+blood 0 0.535294118 0 kegg serum_bileacids NA 0.0766 no no no no no dn PPAR signaling pathway GUDCA+blood 0 -0.535294118 0 kegg serum_bileacids NA 0.0766 no no no no no dn Prion disease GUDCA+blood 0 0.605882353 0 kegg serum_bileacids NA 0.0766 no no no no no dn Progesterone-mediated oocyte maturation GUDCA+blood -0.475438596 0 0 kegg serum_bileacids NA 0.0766 no no no no no dn Prolactin signaling pathway GUDCA+blood 0 -0.597058824 -0.425384615 kegg serum_bileacids NA 0.0766 no no no no no dn Protein processing in endoplasmic reticulum GUDCA+blood 0 0.629411765 0 kegg serum_bileacids NA 0.0766 no no no no no dn Purine metabolism GUDCA+blood 0 0.55 0 kegg serum_bileacids NA 0.0766 no no no no no dn Retrograde endocannabinoid signaling GUDCA+blood 0 0.552941176 0.420769231 kegg serum_bileacids NA 0.0766 no no up no no dn RIG-I-like receptor signaling pathway GUDCA+blood 0 0 -0.423076923 kegg serum_bileacids NA 0.0766 no no no no no dn RNA degradation GUDCA+blood 0 0.570588235 0 kegg serum_bileacids NA 0.0766 no no no no no dn Roseburia GUDCA+blood 0 0.519926523 0 butyrate-producing Genus serum_bileacids 0.495 0.0766 no no no no no dn Sphingolipid signaling pathway GUDCA+blood 0 -0.520588235 0 kegg serum_bileacids NA 0.0766 no no no no no dn Systemic lupus erythematosus GUDCA+blood 0 -0.523529412 0 kegg serum_bileacids NA 0.0766 no no no no no dn Thermogenesis GUDCA+blood 0 0.555882353 0 kegg serum_bileacids NA 0.0766 no no no no no dn Tuberculosis GUDCA+blood 0 -0.511764706 0 kegg serum_bileacids NA 0.0766 no no dn no no dn Type I diabetes mellitus GUDCA+blood 0 -0.529411765 0 kegg serum_bileacids NA 0.0766 no no no no no dn Ubiquitin mediated proteolysis GUDCA+blood 0 0.570588235 0 kegg serum_bileacids NA 0.0766 no no no no no dn UDCA+stool GUDCA+blood 0 0 0.616541353 stool_bileacids serum_bileacids 0.266 0.0766 no no no no no dn Viral carcinogenesis GUDCA+blood 0 -0.585294118 0 kegg serum_bileacids NA 0.0766 no no no no no dn Wnt signaling pathway GUDCA+blood 0 0.514705882 0 kegg serum_bileacids NA 0.0766 no no no no no dn Yersinia infection GUDCA+blood 0 -0.541176471 0 kegg serum_bileacids NA 0.0766 no no no no no dn 3-(3-Hydroxyphenyl)propanoic acid+stool GUDCA+stool 0 -0.615834573 0 yes stool_cometabolism stool_bileacids 0.33 0.0085 no no no no dn no B cell receptor signaling pathway GUDCA+stool 0 0.674126972 0 yes kegg stool_bileacids NA 0.0085 no no no no dn no C-type lectin receptor signaling pathway GUDCA+stool 0 0.649342892 0 yes kegg stool_bileacids NA 0.0085 no no no no dn no Insulin resistance GUDCA+stool 0 0.609688364 0 yes kegg stool_bileacids NA 0.0085 no no no no dn no Neurotrophin signaling pathway GUDCA+stool 0 0.684040604 0 yes kegg stool_bileacids NA 0.0085 no no no no dn no TNF signaling pathway GUDCA+stool 0 0.609688364 0 yes kegg stool_bileacids NA 0.0085 no no no no dn no Toll-like receptor signaling pathway GUDCA+stool 0 0.604731548 0 yes yes kegg stool_bileacids NA 0.0085 no no no no dn no 12-ketoDCA+blood HCA+blood 0.48284992 0 0 serum_bileacids serum_bileacids 0.517 0.544 no no no no no no 14:0/16:0-PC+blood HCA+blood 0 0.486027821 0 serum_phospholipids serum_bileacids 0.0358 0.544 no up no no no no 16:0/20:5-PG+blood HCA+blood -0.521189187 0 0 serum_phospholipids serum_bileacids 0.00656 0.544 no up no no no no 16:0/22:6-PC+blood HCA+blood -0.556239922 0 0 serum_phospholipids serum_bileacids 4.53E-05 0.544 no up up no no no 16:1/16:0-PC+blood HCA+blood -0.556239922 0 0 serum_phospholipids serum_bileacids 0.0215 0.544 no up up no no no 16:1/16:1-PC+blood HCA+blood -0.656820291 0 0 serum_phospholipids serum_bileacids 0.0177 0.544 no no up no no no 16:1/18:1-PG+blood HCA+blood -0.533380747 0 0 serum_phospholipids serum_bileacids 3.21E-05 0.544 no up up no no no 16:1/18:2-PG+blood HCA+blood -0.489186342 0 0 serum_phospholipids serum_bileacids 1.40E-08 0.544 no up up no no no 18:0/16:0-PC+blood HCA+blood -0.46708914 0 0 serum_phospholipids serum_bileacids 9.64E-07 0.544 up up up no no no 18:0/18:0-PS+blood HCA+blood -0.448039828 0 0 serum_phospholipids serum_bileacids 0.00617 0.544 no up no no no no 18:0/18:1-PC+blood HCA+blood -0.467851112 0 0 serum_phospholipids serum_bileacids 0.393 0.544 no no no no no no 18:0/20:3-PI+blood HCA+blood -0.526522995 0 0 serum_phospholipids serum_bileacids 0.377 0.544 no no no no no no 18:0/20:4-PI+blood HCA+blood -0.563859647 0 0 serum_phospholipids serum_bileacids 0.167 0.544 no no no no no no 18:0/22:6-PA+blood HCA+blood -0.637770979 0 0 serum_phospholipids serum_bileacids 0.22 0.544 no no no no no no 18:1-LPE+blood HCA+blood 0.569955427 0 0 serum_phospholipids serum_bileacids 0.117 0.544 no no no no no no 18:1/18:0-PS+blood HCA+blood -0.695680889 0 0 serum_phospholipids serum_bileacids 0.193 0.544 no no no no no no 18:1/18:1-PG+blood HCA+blood -0.583670932 0 0 serum_phospholipids serum_bileacids 0.00352 0.544 no up up no no no 18:1/18:2-PG+blood HCA+blood -0.481566617 0 0 serum_phospholipids serum_bileacids 5.58E-07 0.544 no up up no no no 18:1/20:4-PC+blood HCA+blood -0.539476527 0 0 serum_phospholipids serum_bileacids 0.582 0.544 no no no no no no 18:1+blood HCA+blood -0.484614507 0 -0.525137052 yes serum_fattyacid serum_bileacids 0.00202 0.544 up no dn no no no 18:2-LPE+blood HCA+blood 0.499091985 0 0 serum_phospholipids serum_bileacids 0.112 0.544 no no no no no no 18:2/18:2-PC+blood HCA+blood 0 0.486027821 0 serum_phospholipids serum_bileacids 1.98E-05 0.544 dn up up no no no 18:2/20:4-PC+blood HCA+blood -0.468613085 0 0 serum_phospholipids serum_bileacids 0.0145 0.544 no no up no no no 18:2n6c+blood HCA+blood 0 0 -0.447392293 serum_fattyacid serum_bileacids 0.15 0.544 no no no no no no 18:3-LPC+blood HCA+blood 0.534904692 0 0 serum_phospholipids serum_bileacids 0.147 0.544 no no no no no no 18:3n3+blood HCA+blood -0.48232859 0 0 serum_fattyacid serum_bileacids 0.291 0.544 no no no no no no 18:3n6+blood HCA+blood 0 0.578723848 0 serum_fattyacid serum_bileacids 0.0463 0.544 up no dn no no no 20:0/20:5-PC+blood HCA+blood -0.829788048 0 0 serum_phospholipids serum_bileacids 0.882 0.544 no no no no no no 20:1-LPA+blood HCA+blood 0 -0.514838748 0 serum_phospholipids serum_bileacids 0.0187 0.544 dn dn no no no no 20:1/20:4-PE+blood HCA+blood -0.45489758 0 0 serum_phospholipids serum_bileacids 0.0042 0.544 up up no no no no 20:2+blood HCA+blood 0 0 -0.523697334 serum_fattyacid serum_bileacids 0.478 0.544 no no no no no no 20:3/18:0-PC+blood HCA+blood -0.579861069 0 0 serum_phospholipids serum_bileacids 0.296 0.544 no no no no no no 20:3/18:0-PI+blood HCA+blood -0.535666665 0 0 serum_phospholipids serum_bileacids 0.289 0.544 no no no no no no 20:4-LPA+blood HCA+blood 0 -0.65388279 0 serum_phospholipids serum_bileacids 0.398 0.544 no no no no no no 20:4/16:0-PE+blood HCA+blood 0 0.497301662 0 serum_phospholipids serum_bileacids 0.00529 0.544 no up up no no no 20:5/18:0-PC+blood HCA+blood -0.575289234 0 0 serum_phospholipids serum_bileacids 3.97E-06 0.544 no up up no no no 22:0/16:0-PE+blood HCA+blood -0.508235655 0 0 serum_phospholipids serum_bileacids 0.091 0.544 no no up no no no 22:1-LPA+blood HCA+blood 0 -0.518596695 0 serum_phospholipids serum_bileacids 0.00373 0.544 no up up no no no acetic acid C2+blood HCA+blood -0.489186342 0 0 serum_scfa serum_bileacids 0.000193 0.544 up dn no no no no Adrenergic signaling in cardiomyocytes HCA+blood 0 0.533016179 0.418291471 kegg serum_bileacids NA 0.544 no no up no no no AGE-RAGE signaling pathway in diabetic complications HCA+blood 0 -0.501307001 0 kegg serum_bileacids NA 0.544 no no no no no no Akkermansia HCA+blood -0.459178196 0 0 acetate-producing Genus serum_bileacids 0.23 0.544 no no no no no no Aldosterone synthesis and secretion HCA+blood 0 0.599454456 0.451722173 kegg serum_bileacids NA 0.544 no up up no no no Allograft rejection HCA+blood 0 -0.542075944 0 kegg serum_bileacids NA 0.544 no no no no no no Alzheimer disease HCA+blood 0 0.533016179 0 kegg serum_bileacids NA 0.544 no no no no no no Amphetamine addiction HCA+blood 0 0.679482381 0.430522216 kegg serum_bileacids NA 0.544 no no no no no no AMPK signaling pathway HCA+blood 0 0.608514221 0 kegg serum_bileacids NA 0.544 no no no no no no Amyotrophic lateral sclerosis HCA+blood 0 0.585864809 0.443976035 kegg serum_bileacids NA 0.544 no no no no no no Apelin signaling pathway HCA+blood 0 0.522446453 0 kegg serum_bileacids NA 0.544 no no no no no no Arginine and proline metabolism HCA+blood 0 -0.533016179 0 kegg serum_bileacids NA 0.544 no up no no no no Autoimmune thyroid disease HCA+blood 0 -0.542075944 0 kegg serum_bileacids NA 0.544 no no no no no no Biosynthesis of amino acids HCA+blood 0 -0.603984339 0 kegg serum_bileacids NA 0.544 no no no no no no Biosynthesis of cofactors HCA+blood 0.541713944 0 0 kegg serum_bileacids NA 0.544 no no no no no no Bladder cancer HCA+blood 0 -0.511876727 0 kegg serum_bileacids NA 0.544 no no no no no no CA+blood HCA+blood 0.921571268 0.810960982 0.732806451 serum_bileacids serum_bileacids 0.606 0.544 no no no no no no capric acid C6+blood HCA+blood 0 -0.532375834 0 serum_scfa serum_bileacids 0.433 0.544 no no no no no no CDCA+blood HCA+blood 0.840455663 0.62757716 0.716619513 serum_bileacids serum_bileacids 0.506 0.544 no no no no no no CDCA+stool HCA+blood 0 0 0.482428456 stool_bileacids serum_bileacids 0.663 0.544 no no no no no no Cell adhesion molecules HCA+blood 0 -0.536036101 0 kegg serum_bileacids NA 0.544 no no no no no no Cell cycle HCA+blood 0 0.58888473 0 kegg serum_bileacids NA 0.544 no no no no no no Cellular senescence HCA+blood 0 -0.507346845 0 kegg serum_bileacids NA 0.544 no no no no no no cGMP-PKG signaling pathway HCA+blood 0 -0.671932577 0 kegg serum_bileacids NA 0.544 no no no no no no Chemokine signaling pathway HCA+blood 0 -0.602474378 0 kegg serum_bileacids NA 0.544 no no no no no no Colorectal cancer HCA+blood 0 0.582844887 0 kegg serum_bileacids NA 0.544 no no no no no no Coprococcus HCA+blood 0 0 -0.412119208 butyrate-producing Genus serum_bileacids 0.612 0.544 no no no no no no Coronavirus disease - COVID-19 HCA+blood 0 0.514896649 0 kegg serum_bileacids NA 0.544 no no no no no no Cushing syndrome HCA+blood 0 0.62361383 0 kegg serum_bileacids NA 0.544 no no up no no no Cysteine+blood HCA+blood 0 -0.57621855 -0.443433069 yes serum_aminoacids serum_bileacids 1.81E-07 0.544 dn up up no no no Cytokine-cytokine receptor interaction HCA+blood 0 -0.619083947 0 kegg serum_bileacids NA 0.544 no no no no no no d18:1-18:0-SM+blood HCA+blood -0.514331435 0 0 serum_phospholipids serum_bileacids 0.97 0.544 no no no no no no d18:1-18:1-SM+blood HCA+blood -0.504425792 0 0 serum_phospholipids serum_bileacids 0.916 0.544 no no no no no no Diabetic cardiomyopathy HCA+blood 0 0.517916571 0 kegg serum_bileacids NA 0.544 no no no no no no Dopaminergic synapse HCA+blood 0 0 0.455799088 kegg serum_bileacids NA 0.544 no up no no no no EGFR tyrosine kinase inhibitor resistance HCA+blood 0 0.569255239 0 kegg serum_bileacids NA 0.544 no no no no no no Endocytosis HCA+blood 0 -0.540565983 0 kegg serum_bileacids NA 0.544 no no no no no no Epithelial cell signaling in Helicobacter pylori infection HCA+blood 0 -0.569255239 0 kegg serum_bileacids NA 0.544 no no no no no no Fc epsilon RI signaling pathway HCA+blood 0 -0.529996257 0 kegg serum_bileacids NA 0.544 no no no no no no Fc gamma R-mediated phagocytosis HCA+blood -0.483800447 -0.711191559 0 kegg serum_bileacids NA 0.544 no no no no no no GCA+blood HCA+blood 0 0.52485994 0 yes serum_bileacids serum_bileacids 0.16 0.544 no no no no no no GCDCA+blood HCA+blood 0.502901847 0.547407623 0 serum_bileacids serum_bileacids 0.31 0.544 no no no no no no Glucagon signaling pathway HCA+blood 0 0.664382773 0 kegg serum_bileacids NA 0.544 no no no no no no "Glycine, serine and threonine metabolism" HCA+blood 0.492710215 0 0 kegg serum_bileacids NA 0.544 no up no no no no Graft-versus-host disease HCA+blood 0 -0.542075944 0 kegg serum_bileacids NA 0.544 no no no no no no GUDCA+blood HCA+blood 0 0.663903982 0 serum_bileacids serum_bileacids 0.0766 0.544 no no dn no no no Huntington disease HCA+blood 0 0.533016179 0 kegg serum_bileacids NA 0.544 no no no no no no IL-17 signaling pathway HCA+blood 0 -0.599454456 0 kegg serum_bileacids NA 0.544 no no no no no no Inflammatory mediator regulation of TRP channels HCA+blood 0 0.597944496 0.410953024 kegg serum_bileacids NA 0.544 no no no no no no Influenza A HCA+blood 0 -0.560195474 0 kegg serum_bileacids NA 0.544 no no no no no no Insulin signaling pathway HCA+blood 0 0.585864809 0 kegg serum_bileacids NA 0.544 no no no no no no Lipid and atherosclerosis HCA+blood 0 -0.738370854 0 kegg serum_bileacids NA 0.544 no no no no no no Lysosome HCA+blood 0 -0.67797242 0 kegg serum_bileacids NA 0.544 no no no no no no Mitophagy - animal HCA+blood 0.517657568 0 0 kegg serum_bileacids NA 0.544 no no no no no no mRNA surveillance pathway HCA+blood 0 0.724781207 0 kegg serum_bileacids NA 0.544 no no no no no no mTOR signaling pathway HCA+blood 0 0.591904652 0 kegg serum_bileacids NA 0.544 no no no no no no Natural killer cell mediated cytotoxicity HCA+blood 0 -0.502816962 0 kegg serum_bileacids NA 0.544 no no no no no no Neuroactive ligand-receptor interaction HCA+blood 0 -0.608514221 0 kegg serum_bileacids NA 0.544 up up up no no no Neutrophil extracellular trap formation HCA+blood 0 -0.67797242 0 kegg serum_bileacids NA 0.544 no no no no no no Nicotinate and nicotinamide metabolism HCA+blood 0 -0.507346845 0 kegg serum_bileacids NA 0.544 no no no no no no Non-alcoholic fatty liver disease HCA+blood 0 0.51640661 0.41258379 kegg serum_bileacids NA 0.544 no no no no no no nutriCA+stool HCA+blood 0 0 0.586481652 stool_bileacids serum_bileacids 0.481 0.544 no no no no no no Olfactory transduction HCA+blood 0 -0.729311089 0 kegg serum_bileacids NA 0.544 no no no no no no Osteoclast differentiation HCA+blood 0 -0.51640661 0 kegg serum_bileacids NA 0.544 no no no no no no "Parathyroid hormone synthesis, secretion and action" HCA+blood 0 0.508856806 0 kegg serum_bileacids NA 0.544 no no no no no no Pathogenic Escherichia coli infection HCA+blood 0 -0.724781207 0 kegg serum_bileacids NA 0.544 no no no no no no Pathways of neurodegeneration - multiple diseases HCA+blood 0 0.520936492 0 kegg serum_bileacids NA 0.544 no no no no no no Peroxisome HCA+blood 0 -0.522446453 0 kegg serum_bileacids NA 0.544 no no no no no no Pertussis HCA+blood -0.465980909 -0.673442538 0 kegg serum_bileacids NA 0.544 no no dn no no no Phagosome HCA+blood 0 -0.650793125 0 kegg serum_bileacids NA 0.544 no no no no no no Phosphatidylinositol signaling system HCA+blood 0 0.51640661 0 kegg serum_bileacids NA 0.544 no no no no no no PI3K-Akt signaling pathway HCA+blood 0 0.504326923 0 yes kegg serum_bileacids NA 0.544 no up up no no no Prevotella HCA+blood 0.468717716 0 0 acetate-producing Genus serum_bileacids 0.287 0.544 no no no no no no Prion disease HCA+blood 0 0.548115788 0 kegg serum_bileacids NA 0.544 no no no no no no Protein processing in endoplasmic reticulum HCA+blood 0 0.619083947 0 kegg serum_bileacids NA 0.544 no no no no no no Proteoglycans in cancer HCA+blood 0.559533481 0 0 kegg serum_bileacids NA 0.544 no no no no no no Regulation of actin cytoskeleton HCA+blood 0 0 0.522660493 kegg serum_bileacids NA 0.544 no no no no no no Rheumatoid arthritis HCA+blood 0 -0.613044104 0 kegg serum_bileacids NA 0.544 no no no no no no Ribosome HCA+blood 0 0.514896649 0 kegg serum_bileacids NA 0.544 no no no no no no Ribosome biogenesis in eukaryotes HCA+blood 0 0.590394691 0 kegg serum_bileacids NA 0.544 no no no no no no RNA degradation HCA+blood 0 0.596434535 0 kegg serum_bileacids NA 0.544 no no no no no no RNA transport HCA+blood 0 0.537546062 0 kegg serum_bileacids NA 0.544 no no no no no no Roseburia HCA+blood 0 0 0.446312505 butyrate-producing Genus serum_bileacids 0.495 0.544 no no no no no no Salmonella infection HCA+blood 0 -0.597944496 0 kegg serum_bileacids NA 0.544 no no no no no no Spinocerebellar ataxia HCA+blood 0 0.661362851 0 kegg serum_bileacids NA 0.544 no no no no no no Staphylococcus aureus infection HCA+blood 0 -0.687032185 0 kegg serum_bileacids NA 0.544 up no no no no no Systemic lupus erythematosus HCA+blood -0.494492169 -0.674952499 0 kegg serum_bileacids NA 0.544 no no no no no no Thermogenesis HCA+blood 0 0.561705435 0 kegg serum_bileacids NA 0.544 no no no no no no Tuberculosis HCA+blood -0.479345562 -0.653813047 0 kegg serum_bileacids NA 0.544 no no dn no no no Type I diabetes mellitus HCA+blood 0 -0.542075944 0 kegg serum_bileacids NA 0.544 no no no no no no Ubiquitin mediated proteolysis HCA+blood 0.518548545 0 0 kegg serum_bileacids NA 0.544 no no no no no no Viral myocarditis HCA+blood 0 -0.49979704 0 kegg serum_bileacids NA 0.544 no no no no no no Viral protein interaction with cytokine and cytokine receptor HCA+blood 0 -0.522446453 0 kegg serum_bileacids NA 0.544 no no no no no no Wnt signaling pathway HCA+blood 0 0.539056022 0 kegg serum_bileacids NA 0.544 no no no no no no Yersinia infection HCA+blood 0 -0.764040189 0 kegg serum_bileacids NA 0.544 no no no no no no 4-hydroxybenzoic acid+stool HCA+stool 0.486068111 0 0 stool_cometabolism stool_bileacids 0.0536 0.155 no dn no no no no Amyotrophic lateral sclerosis HCA+stool 0 0 0.518915867 kegg stool_bileacids NA 0.155 no no no no no no Antigen processing and presentation HCA+stool 0.605779154 0 0 kegg stool_bileacids NA 0.155 no no no no no no CA+stool HCA+stool 0.568627451 0 0.419960474 stool_bileacids stool_bileacids 0.827 0.155 no no no no no no Cardiac muscle contraction HCA+stool 0 0 0.43308865 kegg stool_bileacids NA 0.155 no no up no no no CDCA+stool HCA+stool 0.655314757 0 0 stool_bileacids stool_bileacids 0.663 0.155 no no no no no no Chemical carcinogenesis - receptor activation HCA+stool -0.492260062 0 0 kegg stool_bileacids NA 0.155 no no no no no no Coronavirus disease - COVID-19 HCA+stool -0.477812178 0 0 kegg stool_bileacids NA 0.155 no no no no no no Cushing syndrome HCA+stool -0.682146543 0 0 kegg stool_bileacids NA 0.155 no no up no no no Endocrine resistance HCA+stool -0.589267286 0 0 kegg stool_bileacids NA 0.155 no no no no no no Epstein-Barr virus infection HCA+stool 0.552115583 0 0 kegg stool_bileacids NA 0.155 no no no no no no Fc gamma R-mediated phagocytosis HCA+stool 0.653250774 0 0 kegg stool_bileacids NA 0.155 no no no no no no GABAergic synapse HCA+stool 0.581011352 0 0 kegg stool_bileacids NA 0.155 no up up no no no "Growth hormone synthesis, secretion and action" HCA+stool -0.506707946 0 0 kegg stool_bileacids NA 0.155 no no no no no no Herpes simplex virus 1 infection HCA+stool 0.512899897 0 0 kegg stool_bileacids NA 0.155 no no no no no no Human immunodeficiency virus 1 infection HCA+stool 0.492260062 0 0 kegg stool_bileacids NA 0.155 no no no no no no Human T-cell leukemia virus 1 infection HCA+stool 0.545923633 0 0 kegg stool_bileacids NA 0.155 no no no no no no Huntington disease HCA+stool 0 0 0.498588368 kegg stool_bileacids NA 0.155 no no no no no no IL-17 signaling pathway HCA+stool 0.55624355 0 0 kegg stool_bileacids NA 0.155 no no no no no no Lipid and atherosclerosis HCA+stool 0.678018576 0 0 kegg stool_bileacids NA 0.155 no no no no no no Long-term depression HCA+stool -0.492260062 0 0 kegg stool_bileacids NA 0.155 no no no no no no Lysosome HCA+stool 0.539731682 0 0 kegg stool_bileacids NA 0.155 no no no no no no Neutrophil extracellular trap formation HCA+stool 0.539731682 0 0 kegg stool_bileacids NA 0.155 no no no no no no NOD-like receptor signaling pathway HCA+stool 0.521155831 0 -0.429700734 kegg stool_bileacids NA 0.155 no no no no no no Non-alcoholic fatty liver disease HCA+stool 0 0 0.450028233 kegg stool_bileacids NA 0.155 no no no no no no Olfactory transduction HCA+stool 0.605779154 0 0 kegg stool_bileacids NA 0.155 no no no no no no Oscillospira HCA+stool -0.665634675 0 0 LPS-producing Genus stool_bileacids 0.62 0.155 no no no no no no Osteoclast differentiation HCA+stool 0.506707946 0 0 kegg stool_bileacids NA 0.155 no no no no no no Peroxisome HCA+stool 0.607843137 0 0 kegg stool_bileacids NA 0.155 no no no no no no Pertussis HCA+stool 0.729618163 0 0 kegg stool_bileacids NA 0.155 no no dn no no no Proteasome HCA+stool 0.481940144 0 0 kegg stool_bileacids NA 0.155 no no no no no no Ribosome HCA+stool -0.484004128 0 0 kegg stool_bileacids NA 0.155 no no no no no no Salmonella infection HCA+stool 0.622291022 0 0 kegg stool_bileacids NA 0.155 no no no no no no Systemic lupus erythematosus HCA+stool 0.568627451 0 0 kegg stool_bileacids NA 0.155 no no no no no no Thyroid hormone signaling pathway HCA+stool -0.475748194 0 0 kegg stool_bileacids NA 0.155 no no no no no no Transcriptional misregulation in cancer HCA+stool 0.488132095 0 0 kegg stool_bileacids NA 0.155 no no no no no no Tuberculosis HCA+stool 0.517027864 0 0 kegg stool_bileacids NA 0.155 no no dn no no no 11-HETE+blood HDCA+blood 0 -0.668320777 0 serum_ARA serum_bileacids 0.464 0.483 no no no no no no 12-ketoDCA+blood HDCA+blood 0 0.893684825 0 serum_bileacids serum_bileacids 0.517 0.483 no no no no no no "12,13-EPOME+blood" HDCA+blood 0 -0.531092282 0.421929486 serum_ARA serum_bileacids 0.901 0.483 no no no no no no 14:0/16:0-PC+blood HDCA+blood 0 0 -0.48342045 serum_phospholipids serum_bileacids 0.0358 0.483 no up no no no no 14:0/18:0-PC+blood HDCA+blood 0 0 -0.46354705 serum_phospholipids serum_bileacids 0.00289 0.483 up up no no no no 16:0-LPE+blood HDCA+blood 0 0 -0.50925587 serum_phospholipids serum_bileacids 0.0711 0.483 up up no no no no 16:0/16:1-PC+blood HDCA+blood 0 -0.490098029 -0.45957237 serum_phospholipids serum_bileacids 0.00283 0.483 up up no no no no 16:0/18:0-PS+blood HDCA+blood 0 -0.515892663 0 serum_phospholipids serum_bileacids 0.377 0.483 no no no no no no 16:0/18:1-PC+blood HDCA+blood 0 0 -0.44764833 serum_phospholipids serum_bileacids 6.15E-07 0.483 up up up no no no 16:0/18:1-PE+blood HDCA+blood 0 -0.65039325 0 serum_phospholipids serum_bileacids 0.000107 0.483 up up no no no no 16:0/18:3-PC+blood HDCA+blood 0 0 -0.440692641 serum_phospholipids serum_bileacids 0.00216 0.483 no up up no no no 16:0/20:3-PC+blood HDCA+blood 0 0 -0.628496269 serum_phospholipids serum_bileacids 5.43E-06 0.483 no up up no no no 16:0/20:4-PE+blood HDCA+blood 0 -0.584064193 0 serum_phospholipids serum_bileacids 0.00139 0.483 up up no no no no 16:0/22:6-PE+blood HDCA+blood 0 -0.543529769 0 serum_phospholipids serum_bileacids 0.000934 0.483 up up no no no no 18:0-LPE+blood HDCA+blood 0 0 -0.416844561 serum_phospholipids serum_bileacids 0.491 0.483 no no no no no no 18:0/16:0-PC+blood HDCA+blood 0 0 -0.44367365 serum_phospholipids serum_bileacids 9.64E-07 0.483 up up up no no no 18:0/18:0-PE+blood HDCA+blood -0.487794926 -0.598803983 0 serum_phospholipids serum_bileacids 0.00896 0.483 up up no no no no 18:0/18:0-PS+blood HDCA+blood 0 -0.550899665 0 serum_phospholipids serum_bileacids 0.00617 0.483 no up no no no no 18:0/18:1-PE+blood HDCA+blood -0.487794926 -0.584064193 0 serum_phospholipids serum_bileacids 0.00716 0.483 up up no no no no 18:0/18:1-PG+blood HDCA+blood -0.487794926 0 0 serum_phospholipids serum_bileacids 0.000842 0.483 no up no no no no 18:0/18:1-PI+blood HDCA+blood 0 -0.633810985 0 serum_phospholipids serum_bileacids 0.599 0.483 no no no no no no 18:0/20:3-PC+blood HDCA+blood 0 0 -0.598686169 serum_phospholipids serum_bileacids 0.0682 0.483 no up no no no no 18:0/20:3-PI+blood HDCA+blood 0 -0.591434088 0 serum_phospholipids serum_bileacids 0.377 0.483 no no no no no no 18:0/22:6-PE+blood HDCA+blood 0 -0.512207715 0 serum_phospholipids serum_bileacids 0.00022 0.483 up up no no no no 18:1/16:0-PE+blood HDCA+blood 0 -0.580379245 0 serum_phospholipids serum_bileacids 0.000182 0.483 up up no no no no 18:1/16:1-PE+blood HDCA+blood 0 -0.615386247 0 serum_phospholipids serum_bileacids 0.000184 0.483 up up no no no no 18:1/18:0-PE+blood HDCA+blood 0 -0.591434088 0 serum_phospholipids serum_bileacids 1.39E-06 0.483 up up no no no no 18:1/18:1-PC+blood HDCA+blood 0 0 -0.631477279 serum_phospholipids serum_bileacids 1.34E-05 0.483 no up up no no no 18:1/18:1-PE+blood HDCA+blood 0 -0.661448092 0 serum_phospholipids serum_bileacids 1.03E-05 0.483 up up no no no no 18:1/18:1-PG+blood HDCA+blood 0 -0.50483782 0 serum_phospholipids serum_bileacids 0.00352 0.483 no up up no no no 18:1/18:2-PE+blood HDCA+blood 0 -0.512207715 0 serum_phospholipids serum_bileacids 0.000293 0.483 up up no no no no 18:1/20:3-PC+blood HDCA+blood 0 0 -0.586762129 serum_phospholipids serum_bileacids 0.00872 0.483 no up up no no no 18:2-LPC+blood HDCA+blood 0.457488141 0 0 serum_phospholipids serum_bileacids 0.00743 0.483 dn no up no no no 18:2/18:2-PS+blood HDCA+blood 0 -0.633810985 0 serum_phospholipids serum_bileacids 0.00674 0.483 up up no no no no 18:3/16:0-PE+blood HDCA+blood 0 0 -0.45361035 serum_phospholipids serum_bileacids 0.00149 0.483 up up no no no no 20:0/20:4-PE+blood HDCA+blood 0 0 -0.44466732 serum_phospholipids serum_bileacids 0.00128 0.483 up up no no no no 20:0+blood HDCA+blood 0 0 -0.411876211 yes serum_fattyacid serum_bileacids 0.000278 0.483 dn no up no no no 20:2-LPC+blood HDCA+blood 0 0 -0.46553439 serum_phospholipids serum_bileacids 0.119 0.483 no no up no no no 20:2-LPE+blood HDCA+blood -0.460374502 0 0 serum_phospholipids serum_bileacids 0.177 0.483 no no no no no no 20:2/18:0-PC+blood HDCA+blood 0 0 -0.598686169 serum_phospholipids serum_bileacids 0.0427 0.483 no up no no no no 20:2/18:1-PE+blood HDCA+blood 0 -0.654078197 -0.549002669 serum_phospholipids serum_bileacids 0.00208 0.483 up up no no no no 20:3-LPC+blood HDCA+blood 0 0 -0.549002669 serum_phospholipids serum_bileacids 0.0292 0.483 no up no no no no 20:3-LPE+blood HDCA+blood 0 0 -0.47447742 serum_phospholipids serum_bileacids 0.084 0.483 no up no no no no 20:3n6+blood HDCA+blood 0 -0.521420084 -0.45957237 serum_fattyacid serum_bileacids 0.0884 0.483 up no no no no no 20:4-LPC+blood HDCA+blood 0 0.619071195 0 serum_phospholipids serum_bileacids 0.949 0.483 no no no no no no 4-hydroxybenzoic acid+stool HDCA+blood 0 0 -0.486204163 stool_cometabolism serum_bileacids 0.0536 0.483 no dn no no no no AA+blood HDCA+blood 0.493567647 0 0 serum_ARA serum_bileacids 0.212 0.483 no no no no no no Adherens junction HDCA+blood 0 0 0.405582262 kegg serum_bileacids NA 0.483 no no no no no no Antigen processing and presentation HDCA+blood 0 -0.552257939 0 kegg serum_bileacids NA 0.483 no no no no no no Betaine+blood HDCA+blood 0 0.510365241 0 serum_choline serum_bileacids 0.857 0.483 no no no no no no Butyricicoccus HDCA+blood -0.536805675 0 0 butyrate-producing Genus serum_bileacids 0.852 0.483 no no no no no no Clostridium HDCA+blood 0 -0.580381 0 Genus serum_bileacids 0.925 0.483 no no no no no no Cysteine+blood HDCA+blood 0.518101712 0 0 yes serum_aminoacids serum_bileacids 1.81E-07 0.483 dn up up no no no Cytokine-cytokine receptor interaction HDCA+blood 0 0 0.506289934 kegg serum_bileacids NA 0.483 no no no no no no d18:0-16:0-SM+blood HDCA+blood 0 0.536159874 0 serum_phospholipids serum_bileacids 0.202 0.483 no no no no no no d18:1-16:0-SM+blood HDCA+blood 0 0.630126038 0 serum_phospholipids serum_bileacids 0.14 0.483 no no no no no no d18:1-20:0-SM+blood HDCA+blood 0 0.528789979 0 serum_phospholipids serum_bileacids 0.933 0.483 no no no no no no d18:1-20:1-SM+blood HDCA+blood 0 0.545372243 0 serum_phospholipids serum_bileacids 0.0992 0.483 no no no no no no d18:1-22:1-SM+blood HDCA+blood 0 0.567481929 0 serum_phospholipids serum_bileacids 0.222 0.483 no no no no no no d18:1-24:1-SM+blood HDCA+blood 0 0.591434088 0 serum_phospholipids serum_bileacids 0.0123 0.483 no dn dn no no no DPA+blood HDCA+blood 0 0 0.4685154 serum_ARA serum_bileacids 0.519 0.483 no no no no no no Endocrine resistance HDCA+blood 0 0.565201484 0 kegg serum_bileacids NA 0.483 no no no no no no Epstein-Barr virus infection HDCA+blood 0 -0.522056333 -0.436950226 kegg serum_bileacids NA 0.483 no no no no no no Focal adhesion HDCA+blood 0 0 0.451808735 kegg serum_bileacids NA 0.483 no up up no no no FoxO signaling pathway HDCA+blood 0 0 0.449607474 kegg serum_bileacids NA 0.483 no no no no no no GCA+stool HDCA+blood 0 -0.606779876 0 stool_bileacids serum_bileacids 0.0809 0.483 no no no no no no GLCA+blood HDCA+blood 0 0 0.455649083 serum_bileacids serum_bileacids 0.319 0.483 no no no no no no GnRH signaling pathway HDCA+blood 0 0.565201484 0 kegg serum_bileacids NA 0.483 no no no no no no "Growth hormone synthesis, secretion and action" HDCA+blood 0 0.573830515 0 kegg serum_bileacids NA 0.483 no no no no no no HDCA+stool HDCA+blood 0 0 0.507974499 stool_bileacids serum_bileacids 0.176 0.483 no no no no no no Hematopoietic cell lineage HDCA+blood 0 0 0.483727013 kegg serum_bileacids NA 0.483 no no no no no no Hepatocellular carcinoma HDCA+blood 0 0 0.458962831 kegg serum_bileacids NA 0.483 no no no no no no Herpes simplex virus 1 infection HDCA+blood 0 -0.522056333 0 kegg serum_bileacids NA 0.483 no no no no no no Hippo signaling pathway HDCA+blood 0 0 0.454009995 kegg serum_bileacids NA 0.483 no no no no no no Human cytomegalovirus infection HDCA+blood 0 0 -0.493082371 kegg serum_bileacids NA 0.483 no no dn no no no Human immunodeficiency virus 1 infection HDCA+blood 0 0 -0.479324492 kegg serum_bileacids NA 0.483 no no no no no no Human T-cell leukemia virus 1 infection HDCA+blood 0 -0.522056333 0 kegg serum_bileacids NA 0.483 no no no no no no Hypertrophic cardiomyopathy HDCA+blood 0 0 0.43419865 kegg serum_bileacids NA 0.483 no up up no no no Kaposi sarcoma-associated herpesvirus infection HDCA+blood 0 0 -0.443554007 kegg serum_bileacids NA 0.483 no no dn no no no Longevity regulating pathway - multiple species HDCA+blood 0 -0.513427302 0.41713888 kegg serum_bileacids NA 0.483 no no no no no no Malaria HDCA+blood 0 0 -0.450157789 kegg serum_bileacids NA 0.483 no no no no no no Phenylacetic acid+stool HDCA+blood 0 0 0.459595975 stool_cometabolism serum_bileacids 0.785 0.483 no no no no no no Primary immunodeficiency HDCA+blood 0 0 0.481525752 kegg serum_bileacids NA 0.483 no no no no no no Proteasome HDCA+blood 0 -0.58677406 0 kegg serum_bileacids NA 0.483 no no no no no no TDCA+stool HDCA+blood 0 -0.690065559 0 stool_bileacids serum_bileacids 0.963 0.483 no no no no no no Thyroid hormone signaling pathway HDCA+blood 0 0 0.450157789 kegg serum_bileacids NA 0.483 no no no no no no 12-ketoDCA+stool HDCA+stool 0 0.644484351 0.510869565 stool_bileacids stool_bileacids 0.505 0.176 no no no no no no 4-hydroxybenzoic acid+stool HDCA+stool 0 0 -0.41798419 stool_cometabolism stool_bileacids 0.0536 0.176 no dn no no no no Adrenergic signaling in cardiomyocytes HDCA+stool 0 0.627272727 0 kegg stool_bileacids NA 0.176 no no up no no no Aldosterone synthesis and secretion HDCA+stool 0 0.745454545 0 kegg stool_bileacids NA 0.176 no up up no no no Allograft rejection HDCA+stool 0 -0.709090909 0 kegg stool_bileacids NA 0.176 no no no no no no Amphetamine addiction HDCA+stool 0.475748194 0.627272727 0 kegg stool_bileacids NA 0.176 no no no no no no Antigen processing and presentation HDCA+stool 0 -0.7 0 kegg stool_bileacids NA 0.176 no no no no no no Apoptosis HDCA+stool 0 -0.636363636 0 kegg stool_bileacids NA 0.176 no no no no no no Arachidonic acid metabolism HDCA+stool 0 0 -0.500846979 kegg stool_bileacids NA 0.176 no no no no no no Autoimmune thyroid disease HDCA+stool 0 -0.709090909 0 kegg stool_bileacids NA 0.176 no no no no no no Axon guidance HDCA+stool 0 -0.718181818 0 kegg stool_bileacids NA 0.176 no up up no no no Bacteroides HDCA+stool -0.473684211 0 0 LPS-producing Genus stool_bileacids 0.000267 0.176 dn dn up no no no Biosynthesis of amino acids HDCA+stool 0 -0.681818182 0 kegg stool_bileacids NA 0.176 no no no no no no Biosynthesis of cofactors HDCA+stool 0 0.727272727 0 kegg stool_bileacids NA 0.176 no no no no no no Butyric acid+stool HDCA+stool 0.630546956 0 0 yes stool_scfa stool_bileacids 0.102 0.176 dn no no no no no CA+stool HDCA+stool -0.647058824 0 -0.482213439 stool_bileacids stool_bileacids 0.827 0.176 no no no no no no Carbon metabolism HDCA+stool 0 -0.7 0 kegg stool_bileacids NA 0.176 no no no no no no CDCA+stool HDCA+stool -0.541795666 0 -0.496047431 stool_bileacids stool_bileacids 0.663 0.176 no no no no no no Cell adhesion molecules HDCA+stool 0 -0.690909091 0 kegg stool_bileacids NA 0.176 no no no no no no Cell cycle HDCA+stool 0 0.627272727 0 kegg stool_bileacids NA 0.176 no no no no no no Cellular senescence HDCA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.176 no no no no no no Central carbon metabolism in cancer HDCA+stool 0 0 0.527950311 kegg stool_bileacids NA 0.176 no no no no no no cGMP-PKG signaling pathway HDCA+stool -0.529411765 -0.7 0 kegg stool_bileacids NA 0.176 no no no no no no Chagas disease HDCA+stool 0 0 0.45567476 kegg stool_bileacids NA 0.176 no no no no no no Chemical carcinogenesis - receptor activation HDCA+stool 0 0.681818182 0 kegg stool_bileacids NA 0.176 no no no no no no Chemokine signaling pathway HDCA+stool -0.519091847 0 0 kegg stool_bileacids NA 0.176 no no no no no no Cocaine addiction HDCA+stool 0 0.645454545 0 kegg stool_bileacids NA 0.176 no no no no no no Collinsella HDCA+stool 0 0 -0.697463419 Genus stool_bileacids 0.128 0.176 no no no no no no Cortisol synthesis and secretion HDCA+stool 0 0.681818182 0 kegg stool_bileacids NA 0.176 no no up no no no Cushing syndrome HDCA+stool 0.479876161 0.809090909 0 kegg stool_bileacids NA 0.176 no no up no no no Cytokine-cytokine receptor interaction HDCA+stool -0.475748194 0 0 kegg stool_bileacids NA 0.176 no no no no no no DCA+stool HDCA+stool 0 0.72027972 0.464426877 stool_bileacids stool_bileacids 0.195 0.176 no no no no no no Dopaminergic synapse HDCA+stool 0 0.627272727 0 kegg stool_bileacids NA 0.176 no up no no no no Endocrine and other factor-regulated calcium reabsorption HDCA+stool 0 0.663636364 0 kegg stool_bileacids NA 0.176 no no no no no no Endocytosis HDCA+stool 0 -0.754545455 0 kegg stool_bileacids NA 0.176 no no no no no no Epithelial cell signaling in Helicobacter pylori infection HDCA+stool -0.545923633 0 0 kegg stool_bileacids NA 0.176 no no no no no no Epstein-Barr virus infection HDCA+stool 0 -0.681818182 0 kegg stool_bileacids NA 0.176 no no no no no no Fc epsilon RI signaling pathway HDCA+stool 0 -0.654545455 0 kegg stool_bileacids NA 0.176 no no no no no no Fc gamma R-mediated phagocytosis HDCA+stool 0 -0.854545455 0 kegg stool_bileacids NA 0.176 no no no no no no Fluid shear stress and atherosclerosis HDCA+stool 0 -0.627272727 0 kegg stool_bileacids NA 0.176 no no no no no no Glucagon signaling pathway HDCA+stool 0 0.654545455 0 kegg stool_bileacids NA 0.176 no no no no no no GnRH signaling pathway HDCA+stool 0 0.609090909 0 kegg stool_bileacids NA 0.176 no no no no no no Graft-versus-host disease HDCA+stool 0 -0.709090909 0 kegg stool_bileacids NA 0.176 no no no no no no HCA+stool HDCA+stool 0 -0.612691249 0 stool_bileacids stool_bileacids 0.155 0.176 no no no no no no Hepatitis B HDCA+stool -0.547987616 0 0 kegg stool_bileacids NA 0.176 no no no no no no Hepatitis C HDCA+stool 0 0 0.462450593 kegg stool_bileacids NA 0.176 no no no no no no Herpes simplex virus 1 infection HDCA+stool 0 -0.690909091 0 kegg stool_bileacids NA 0.176 no no no no no no Human cytomegalovirus infection HDCA+stool 0 -0.745454545 0 kegg stool_bileacids NA 0.176 no no dn no no no Human immunodeficiency virus 1 infection HDCA+stool 0 -0.681818182 0 kegg stool_bileacids NA 0.176 no no no no no no Human papillomavirus infection HDCA+stool 0 -0.627272727 0 kegg stool_bileacids NA 0.176 no no no no no no Human T-cell leukemia virus 1 infection HDCA+stool 0 -0.672727273 0 kegg stool_bileacids NA 0.176 no no no no no no IL-17 signaling pathway HDCA+stool -0.704850361 -0.781818182 0 kegg stool_bileacids NA 0.176 no no no no no no Inflammatory bowel disease HDCA+stool 0 -0.609090909 0 kegg stool_bileacids NA 0.176 no no no no no no Influenza A HDCA+stool 0 -0.627272727 0 kegg stool_bileacids NA 0.176 no no no no no no Insulin secretion HDCA+stool 0 0.8 0 yes kegg stool_bileacids NA 0.176 no up up no no no Intestinal immune network for IgA production HDCA+stool 0 -0.654545455 0 kegg stool_bileacids NA 0.176 no no no no no no Leukocyte transendothelial migration HDCA+stool 0 -0.790909091 0 kegg stool_bileacids NA 0.176 no no no no no no Lipid and atherosclerosis HDCA+stool 0 -0.727272727 0 kegg stool_bileacids NA 0.176 no no no no no no Lysosome HDCA+stool 0 -0.881818182 -0.500846979 kegg stool_bileacids NA 0.176 no no no no no no MAPK signaling pathway HDCA+stool 0 0 0.518915867 kegg stool_bileacids NA 0.176 no no no no no no Measles HDCA+stool 0 0 0.500846979 kegg stool_bileacids NA 0.176 no no no no no no Morphine addiction HDCA+stool 0 0.8 0 kegg stool_bileacids NA 0.176 no up up no no no mRNA surveillance pathway HDCA+stool 0 0.645454545 0 kegg stool_bileacids NA 0.176 no no no no no no Natural killer cell mediated cytotoxicity HDCA+stool 0 -0.754545455 0 kegg stool_bileacids NA 0.176 no no no no no no Neuroactive ligand-receptor interaction HDCA+stool 0 -0.909090909 0 kegg stool_bileacids NA 0.176 up up up no no no Neutrophil extracellular trap formation HDCA+stool -0.492260062 -0.872727273 0 kegg stool_bileacids NA 0.176 no no no no no no NF-kappa B signaling pathway HDCA+stool -0.481940144 0 0 kegg stool_bileacids NA 0.176 no no no no no no NOD-like receptor signaling pathway HDCA+stool 0 0 0.459062676 kegg stool_bileacids NA 0.176 no no no no no no Odoribacter HDCA+stool 0 -0.615384615 0 butyrate-producing Genus stool_bileacids 0.798 0.176 no no no no no no Osteoclast differentiation HDCA+stool -0.568627451 -0.854545455 0 kegg stool_bileacids NA 0.176 no no no no no no p53 signaling pathway HDCA+stool 0 0.781818182 0 kegg stool_bileacids NA 0.176 no no no no no no Pancreatic secretion HDCA+stool 0 0.636363636 0 kegg stool_bileacids NA 0.176 no no no no no no Pathogenic Escherichia coli infection HDCA+stool 0 -0.872727273 0 kegg stool_bileacids NA 0.176 no no no no no no Pathways in cancer HDCA+stool 0 0 0.604743083 kegg stool_bileacids NA 0.176 no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer HDCA+stool 0 0 0.568605308 kegg stool_bileacids NA 0.176 no no no no no no Peroxisome HDCA+stool -0.475748194 -0.690909091 0 kegg stool_bileacids NA 0.176 no no no no no no Pertussis HDCA+stool 0 -0.790909091 0 kegg stool_bileacids NA 0.176 no no dn no no no Phagosome HDCA+stool 0 -0.863636364 0 kegg stool_bileacids NA 0.176 no no no no no no PPAR signaling pathway HDCA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.176 no no no no no no Prolactin signaling pathway HDCA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.176 no no no no no no Protein processing in endoplasmic reticulum HDCA+stool 0.55624355 0 0 kegg stool_bileacids NA 0.176 no no no no no no Pyramidobacter HDCA+stool 0 0 0.414706784 Genus stool_bileacids 0.45 0.176 no no no no no no Regulation of lipolysis in adipocytes HDCA+stool 0 0.627272727 0 kegg stool_bileacids NA 0.176 no no no no no no Rheumatoid arthritis HDCA+stool 0 -0.809090909 0 kegg stool_bileacids NA 0.176 no no no no no no RIG-I-like receptor signaling pathway HDCA+stool -0.622291022 0 0 kegg stool_bileacids NA 0.176 no no no no no no Ruminococcus HDCA+stool -0.52453321 0 0 Genus stool_bileacids 0.0679 0.176 no no dn no no no Ruminococcus HDCA+stool 0.568627451 0 0 acetate-producing Genus stool_bileacids 0.335 0.176 no no no no no no Salmonella infection HDCA+stool 0 -0.790909091 0 kegg stool_bileacids NA 0.176 no no no no no no Signaling pathways regulating pluripotency of stem cells HDCA+stool 0 0 0.489553924 kegg stool_bileacids NA 0.176 no no no no no no Sphingolipid signaling pathway HDCA+stool 0 -0.8 0 kegg stool_bileacids NA 0.176 no no no no no no Spliceosome HDCA+stool 0 0.654545455 0 kegg stool_bileacids NA 0.176 no no no no no no Staphylococcus aureus infection HDCA+stool 0 -0.890909091 0 kegg stool_bileacids NA 0.176 up no no no no no Systemic lupus erythematosus HDCA+stool 0 -0.872727273 0 kegg stool_bileacids NA 0.176 no no no no no no T cell receptor signaling pathway HDCA+stool 0 0 0.674760023 kegg stool_bileacids NA 0.176 no no no no no no Thyroid hormone synthesis HDCA+stool 0.529411765 0.763636364 0 kegg stool_bileacids NA 0.176 no no no no no no Toll-like receptor signaling pathway HDCA+stool -0.471620227 0 0 yes kegg stool_bileacids NA 0.176 no no no no no no Transcriptional misregulation in cancer HDCA+stool -0.5500516 0 0 kegg stool_bileacids NA 0.176 no no no no no no Tuberculosis HDCA+stool 0 -0.890909091 0 kegg stool_bileacids NA 0.176 no no dn no no no Type I diabetes mellitus HDCA+stool 0 -0.709090909 0 kegg stool_bileacids NA 0.176 no no no no no no Vasopressin-regulated water reabsorption HDCA+stool 0 0.690909091 0 kegg stool_bileacids NA 0.176 no no no no no no Viral carcinogenesis HDCA+stool 0 -0.772727273 0 kegg stool_bileacids NA 0.176 no no no no no no Viral myocarditis HDCA+stool 0 -0.709090909 0 kegg stool_bileacids NA 0.176 no no no no no no Yersinia infection HDCA+stool 0 -0.727272727 0 kegg stool_bileacids NA 0.176 no no no no no no 15-HETE+blood Heart_Rate+clinic 0.509933876 0 0 serum_ARA clinic 0.819 0.00151 no no no up up no 16:0/16:0-PC+blood Heart_Rate+clinic 0 0 0.46 serum_phospholipids clinic 0.00079 0.00151 no up up up up no 16:0/18:2-PI+blood Heart_Rate+clinic 0 -0.692857143 0 serum_phospholipids clinic 0.269 0.00151 no no no up up no 16:0/20:5-PC+blood Heart_Rate+clinic 0 0.617857143 0 serum_phospholipids clinic 0.628 0.00151 no no no up up no 16:0/22:6-PC+blood Heart_Rate+clinic 0 0.582142857 0 serum_phospholipids clinic 4.53E-05 0.00151 no up up up up no 18:0-LPE+blood Heart_Rate+clinic -0.521155831 0 0 serum_phospholipids clinic 0.491 0.00151 no no no up up no 18:0/18:0-PC+blood Heart_Rate+clinic -0.568627451 0 0 serum_phospholipids clinic 0.426 0.00151 no no no up up no 18:0/18:1-PC+blood Heart_Rate+clinic -0.554179567 0 0 serum_phospholipids clinic 0.393 0.00151 no no no up up no 18:0/20:4-PC+blood Heart_Rate+clinic 0 0.592857143 0 serum_phospholipids clinic 0.454 0.00151 no no no up up no 18:0/20:5-PC+blood Heart_Rate+clinic 0 0.653571429 0 serum_phospholipids clinic 0.17 0.00151 no no no up up no 18:1/18:1-PE+blood Heart_Rate+clinic 0 -0.610714286 0 serum_phospholipids clinic 1.03E-05 0.00151 up up no up up no 18:1/20:4-PC+blood Heart_Rate+clinic 0 0.557142857 0 serum_phospholipids clinic 0.582 0.00151 no no no up up no 20:1-LPA+blood Heart_Rate+clinic 0.572755418 0 0 serum_phospholipids clinic 0.0187 0.00151 dn dn no up up no 20:2+blood Heart_Rate+clinic 0.473684211 0 0 serum_fattyacid clinic 0.478 0.00151 no no no up up no 20:4n6+blood Heart_Rate+clinic 0 0.596428571 0 serum_fattyacid clinic 0.133 0.00151 no no no up up no 20:5/18:0-PC+blood Heart_Rate+clinic 0 0.532142857 0 serum_phospholipids clinic 3.97E-06 0.00151 no up up up up no 20:5n3+blood Heart_Rate+clinic 0 0.607142857 0 serum_fattyacid clinic 0.988 0.00151 no no no up up no 22:6n3+blood Heart_Rate+clinic 0 0.525 0 serum_fattyacid clinic 0.792 0.00151 no no no up up no 9-HODE+blood Heart_Rate+clinic 0.475748194 0 0.575384615 serum_ARA clinic 0.297 0.00151 no no no up up no AA+blood Heart_Rate+clinic 0 0.592857143 0 serum_ARA clinic 0.212 0.00151 no no no up up no Adherens junction Heart_Rate+clinic 0 -0.496103896 0 kegg clinic NA 0.00151 no no no up up no Alistipes Heart_Rate+clinic 0 0 0.460177985 Genus clinic 0.0114 0.00151 no up no up up no Alzheimer disease Heart_Rate+clinic 0 -0.535064935 0 kegg clinic NA 0.00151 no no no up up no Amyotrophic lateral sclerosis Heart_Rate+clinic 0 -0.531168831 0 kegg clinic NA 0.00151 no no no up up no Arrhythmogenic right ventricular cardiomyopathy Heart_Rate+clinic 0 -0.475324675 0 kegg clinic NA 0.00151 no up up up up no Bacteroides Heart_Rate+clinic 0 0.442123094 0 LPS-producing Genus clinic 0.000267 0.00151 dn dn up up up no C-peptide Heart_Rate+clinic 0 0 -0.531856379 DM-assocaited hormones clinic 0.228 0.00151 no no no up up no Calcium signaling pathway Heart_Rate+clinic 0 -0.462337662 0 kegg clinic NA 0.00151 no up up up up no Cardiac muscle contraction Heart_Rate+clinic 0 -0.515584416 0 kegg clinic NA 0.00151 no no up up up no Cholinergic synapse Heart_Rate+clinic 0 0.476623377 0 kegg clinic NA 0.00151 no no no up up no Circadian entrainment Heart_Rate+clinic 0 -0.485714286 0 kegg clinic NA 0.00151 no up up up up no Cocaine addiction Heart_Rate+clinic 0 -0.444155844 0 kegg clinic NA 0.00151 no no no up up no d18:1-20:1-SM+blood Heart_Rate+clinic 0.496388029 0 0 serum_phospholipids clinic 0.0992 0.00151 no no no up up no Diabetic cardiomyopathy Heart_Rate+clinic 0 -0.533766234 0 kegg clinic NA 0.00151 no no no up up no Dilated cardiomyopathy Heart_Rate+clinic 0 -0.592207792 0 kegg clinic NA 0.00151 no up up up up no DMG+blood Heart_Rate+clinic 0 -0.514285714 0 serum_choline clinic 0.909 0.00151 no no no up up no Endocrine and other factor-regulated calcium reabsorption Heart_Rate+clinic 0 -0.47012987 0 kegg clinic NA 0.00151 no no no up up no EPA+blood Heart_Rate+clinic 0 0.642857143 0 serum_ARA clinic 0.212 0.00151 no no no up up no FoxO signaling pathway Heart_Rate+clinic 0 0.490909091 0 kegg clinic NA 0.00151 no no no up up no Gastric acid secretion Heart_Rate+clinic 0 -0.577922078 0 kegg clinic NA 0.00151 no no no up up no GCDCA+blood Heart_Rate+clinic -0.469556244 0 0 serum_bileacids clinic 0.31 0.00151 no no no up up no Gemmiger Heart_Rate+clinic -0.46454165 0 0 butyrate-producing Genus clinic 0.595 0.00151 no no no up up no GPC+blood Heart_Rate+clinic 0.599587203 0 0 serum_choline clinic 0.00427 0.00151 no up up up up no HDCA+blood Heart_Rate+clinic 0.481869425 0 0 serum_bileacids clinic 0.483 0.00151 no no no up up no Hepatocellular carcinoma Heart_Rate+clinic 0 -0.493506494 0 kegg clinic NA 0.00151 no no no up up no Huntington disease Heart_Rate+clinic 0 -0.554545455 0 kegg clinic NA 0.00151 no no no up up no Hypertrophic cardiomyopathy Heart_Rate+clinic 0 -0.474025974 0 kegg clinic NA 0.00151 no up up up up no IL-1ra Heart_Rate+clinic -0.615384615 0 0 yes serum_cytokines clinic 0.0288 0.00151 no up no up up no Inflammatory mediator regulation of TRP channels Heart_Rate+clinic 0 -0.438961039 0 kegg clinic NA 0.00151 no no no up up no iso-DCA+blood Heart_Rate+clinic 0.533539732 0 0 serum_bileacids clinic 0.38 0.00151 no no no up up no L-2-Aminobutyric acid+blood Heart_Rate+clinic 0 0.557142857 0 yes serum_aminoacids clinic 0.000328 0.00151 up up no up up no L-Proline+blood Heart_Rate+clinic 0 -0.821428571 0 yes serum_aminoacids clinic 0.00265 0.00151 up up no up up no Long-term depression Heart_Rate+clinic 0 -0.492207792 0 kegg clinic NA 0.00151 no no no up up no Longevity regulating pathway - multiple species Heart_Rate+clinic 0 0.457142857 0 kegg clinic NA 0.00151 no no no up up no MAPK signaling pathway Heart_Rate+clinic 0 0.627272727 0 kegg clinic NA 0.00151 no no no up up no Measles Heart_Rate+clinic 0 0.48961039 0 kegg clinic NA 0.00151 no no no up up no Melanogenesis Heart_Rate+clinic 0 -0.457142857 0 kegg clinic NA 0.00151 no no no up up no Mineral absorption Heart_Rate+clinic 0 -0.492207792 0 kegg clinic NA 0.00151 no no no up up no Mitophagy - animal Heart_Rate+clinic 0 -0.522077922 0 kegg clinic NA 0.00151 no no no up up no Morphine addiction Heart_Rate+clinic 0 -0.479220779 0 kegg clinic NA 0.00151 no up up up up no Non-alcoholic fatty liver disease Heart_Rate+clinic 0 -0.535064935 0 kegg clinic NA 0.00151 no no no up up no Oscillospira Heart_Rate+clinic 0 0.456804065 0 LPS-producing Genus clinic 0.62 0.00151 no no no up up no Oxidative phosphorylation Heart_Rate+clinic 0 -0.561038961 0 kegg clinic NA 0.00151 no no no up up no Oxytocin signaling pathway Heart_Rate+clinic 0 -0.474025974 0 kegg clinic NA 0.00151 no no no up up no Pancreatic secretion Heart_Rate+clinic 0 -0.464935065 0 kegg clinic NA 0.00151 no no no up up no Parabacteroides Heart_Rate+clinic 0 0.473743648 0 Genus clinic 4.19E-05 0.00151 no up up up up no Parkinson disease Heart_Rate+clinic 0 -0.564935065 0 kegg clinic NA 0.00151 no no no up up no Pathways of neurodegeneration - multiple diseases Heart_Rate+clinic 0 -0.536363636 0 kegg clinic NA 0.00151 no no no up up no PI3K-Akt signaling pathway Heart_Rate+clinic 0 0.641558442 0 yes kegg clinic NA 0.00151 no up up up up no Platelet activation Heart_Rate+clinic 0 -0.58961039 0 kegg clinic NA 0.00151 no no no up up no Progesterone-mediated oocyte maturation Heart_Rate+clinic 0 0.48961039 0 kegg clinic NA 0.00151 no no no up up no Rap1 signaling pathway Heart_Rate+clinic 0 -0.622077922 0 kegg clinic NA 0.00151 no no no up up no Renin secretion Heart_Rate+clinic 0 -0.516883117 0 kegg clinic NA 0.00151 no no no up up no Roseburia Heart_Rate+clinic -0.424901186 0 0 butyrate-producing Genus clinic 0.495 0.00151 no no no up up no Ruminococcus Heart_Rate+clinic 0 -0.477351857 0 Genus clinic 0.0679 0.00151 no no dn up up no Shigellosis Heart_Rate+clinic 0 -0.5 0 kegg clinic NA 0.00151 no no no up up no Spliceosome Heart_Rate+clinic 0 0.450649351 0 kegg clinic NA 0.00151 no no no up up no T cell receptor signaling pathway Heart_Rate+clinic 0 0.538961039 0 kegg clinic NA 0.00151 no no no up up no TCA+stool Heart_Rate+clinic 0 -0.751710379 0 stool_bileacids clinic 0.458 0.00151 no no no up up no Thermogenesis Heart_Rate+clinic 0 -0.450649351 0 kegg clinic NA 0.00151 no no no up up no Thyroid hormone signaling pathway Heart_Rate+clinic 0 -0.537662338 0 kegg clinic NA 0.00151 no no no up up no Thyroid hormone synthesis Heart_Rate+clinic 0 -0.502597403 0 kegg clinic NA 0.00151 no no no up up no TLCA+stool Heart_Rate+clinic 0.65380417 0 0 stool_bileacids clinic 0.243 0.00151 no no no up up no TXB2+blood Heart_Rate+clinic 0 0.573570391 0 yes serum_ARA clinic 0.0644 0.00151 dn no no up up no Ubiquitin mediated proteolysis Heart_Rate+clinic 0 -0.496103896 0 kegg clinic NA 0.00151 no no no up up no Vascular smooth muscle contraction Heart_Rate+clinic 0 -0.605194805 0 kegg clinic NA 0.00151 no no no up up no Vasopressin-regulated water reabsorption Heart_Rate+clinic 0 -0.47012987 0 kegg clinic NA 0.00151 no no no up up no Vibrio cholerae infection Heart_Rate+clinic 0 -0.642857143 0 kegg clinic NA 0.00151 no no no up up no 2-Oxocarboxylic acid metabolism Hedgehog signaling pathway 0 0.614624506 0 kegg kegg NA NA no no no no no no ABC transporters Hedgehog signaling pathway 0 0.557312253 0.486229086 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes Hedgehog signaling pathway 0.439130435 0 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Hedgehog signaling pathway 0 0 -0.500900901 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Hedgehog signaling pathway -0.625217391 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Hedgehog signaling pathway -0.583478261 0.455533597 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Hedgehog signaling pathway 0 0.830039526 0.497297297 kegg kegg NA NA no no no no no no AMPK signaling pathway Hedgehog signaling pathway 0 0.433794466 0 kegg kegg NA NA no no no no no no Antifolate resistance Hedgehog signaling pathway 0 0.779644269 0 kegg kegg NA NA no no no no no no Apoptosis Hedgehog signaling pathway -0.49826087 -0.559288538 -0.42985843 kegg kegg NA NA no no no no no no Apoptosis - multiple species Hedgehog signaling pathway 0 0.654150198 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Hedgehog signaling pathway 0 0 -0.615701416 kegg kegg NA NA no no no no no no Arginine and proline metabolism Hedgehog signaling pathway -0.473043478 -0.483201581 -0.403346203 kegg kegg NA NA no up no no no no Arginine biosynthesis Hedgehog signaling pathway 0 -0.423913043 -0.627027027 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Hedgehog signaling pathway 0 0 0.421879022 kegg kegg NA NA no no no no no no Autophagy - other Hedgehog signaling pathway 0 0 0.643243243 kegg kegg NA NA no no no no no no Basal transcription factors Hedgehog signaling pathway 0 0.760869565 0.63989704 kegg kegg NA NA no no no no no no Base excision repair Hedgehog signaling pathway 0 0.841897233 0.447104247 kegg kegg NA NA no no no no no no beta-Alanine metabolism Hedgehog signaling pathway -0.47826087 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Hedgehog signaling pathway -0.69826087 -0.563241107 -0.726126126 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Hedgehog signaling pathway 0 0.54743083 -0.441441441 kegg kegg NA NA no no no no no no Butanoate metabolism Hedgehog signaling pathway 0 0.536561265 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Hedgehog signaling pathway 0.66 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Hedgehog signaling pathway 0.443478261 -0.519762846 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Hedgehog signaling pathway -0.64173913 0 -0.548519949 kegg kegg NA NA no no no no no no Cardiac muscle contraction Hedgehog signaling pathway 0.515652174 0 0 kegg kegg NA NA no no up no no no Cell cycle Hedgehog signaling pathway 0 0.874505929 0.783783784 kegg kegg NA NA no no no no no no Cellular senescence Hedgehog signaling pathway 0 -0.43972332 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Hedgehog signaling pathway 0 -0.701581028 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Hedgehog signaling pathway 0 -0.690711462 -0.485714286 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Hedgehog signaling pathway 0 0.43972332 0 kegg kegg NA NA no no no no no no DNA replication Hedgehog signaling pathway 0 0.703557312 0.461261261 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Hedgehog signaling pathway -0.471304348 0.433794466 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Hedgehog signaling pathway -0.527826087 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Hedgehog signaling pathway 0.573043478 0 0 kegg kegg NA NA no no no no no no Endocytosis Hedgehog signaling pathway -0.450434783 -0.461462451 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Hedgehog signaling pathway 0.607826087 0 0.716602317 kegg kegg NA NA no no no no no no Ether lipid metabolism Hedgehog signaling pathway 0.548695652 0.501976285 0.505534106 kegg kegg NA NA no no no no no no Fanconi anemia pathway Hedgehog signaling pathway 0 0.89229249 0.614157014 kegg kegg NA NA no no no no no no Fatty acid metabolism Hedgehog signaling pathway -0.434782609 0 0 kegg kegg NA NA no no no no no no Ferroptosis Hedgehog signaling pathway 0 -0.489130435 -0.611325611 kegg kegg NA NA no no no no no no Folate biosynthesis Hedgehog signaling pathway 0 0.441699605 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Hedgehog signaling pathway -0.610434783 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Hedgehog signaling pathway -0.494782609 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Hedgehog signaling pathway 0 0 -0.581724582 kegg kegg NA NA no no no no no no Glycerolipid metabolism Hedgehog signaling pathway 0 0.433794466 0.733590734 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Hedgehog signaling pathway 0.439130435 0.490118577 0.786615187 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Hedgehog signaling pathway 0 0 -0.448648649 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Hedgehog signaling pathway -0.64 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Hedgehog signaling pathway 0 0.664031621 0.558043758 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Hedgehog signaling pathway 0.657391304 0 0.521235521 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Hedgehog signaling pathway 0 -0.490118577 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Hedgehog signaling pathway 0 0.678853755 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Hedgehog signaling pathway 0.56 0 0.461776062 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Hedgehog signaling pathway 0 0.586956522 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Hedgehog signaling pathway 0 -0.459486166 -0.601801802 kegg kegg NA NA no no no no no no Homologous recombination Hedgehog signaling pathway 0 0.721343874 0.544401544 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Hedgehog signaling pathway 0 0.657114625 0.757014157 kegg kegg NA NA no no no no no no Lysine degradation Hedgehog signaling pathway 0 0.794466403 0.855855856 kegg kegg NA NA no no no no no no Lysosome Hedgehog signaling pathway 0 -0.769762846 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Hedgehog signaling pathway 0.604347826 0.608695652 0.831145431 kegg kegg NA NA no no no no no no MAPK signaling pathway Hedgehog signaling pathway 0 0.517786561 0.564993565 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Hedgehog signaling pathway -0.484347826 0 0 kegg kegg NA NA no no no no no no Mismatch repair Hedgehog signaling pathway 0 0.551383399 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Hedgehog signaling pathway 0.68173913 0.565217391 0.815186615 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Hedgehog signaling pathway 0 0.466403162 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Hedgehog signaling pathway 0.511304348 0.671936759 0.680823681 kegg kegg NA NA no no no no no no Necroptosis Hedgehog signaling pathway 0 0 -0.584041184 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Hedgehog signaling pathway 0 -0.580039526 -0.598970399 kegg kegg NA NA up up up no no no Nicotinate and nicotinamide metabolism Hedgehog signaling pathway 0 -0.48715415 -0.482625483 kegg kegg NA NA no no no no no no Nitrogen metabolism Hedgehog signaling pathway -0.487826087 -0.519762846 -0.594337194 kegg kegg NA NA no no no no no no Notch signaling pathway Hedgehog signaling pathway 0.584347826 0 0.718918919 kegg kegg NA NA no no no no no no Nucleotide excision repair Hedgehog signaling pathway 0 0.727272727 0 kegg kegg NA NA no no no no no no One carbon pool by folate Hedgehog signaling pathway 0 0.790513834 0.664350064 kegg kegg NA NA no no no no no no Oocyte meiosis Hedgehog signaling pathway 0 0 0.498841699 kegg kegg NA NA no no no no no no Other glycan degradation Hedgehog signaling pathway -0.494782609 0 0.626254826 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Hedgehog signaling pathway 0 0.760869565 0.853796654 kegg kegg NA NA no no no no no no Oxidative phosphorylation Hedgehog signaling pathway 0.468695652 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Hedgehog signaling pathway 0.444347826 0.510869565 0.563191763 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Hedgehog signaling pathway 0 -0.436758893 -0.447876448 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Hedgehog signaling pathway 0 0.545454545 0.401287001 kegg kegg NA NA no no no no no no Pentose phosphate pathway Hedgehog signaling pathway -0.529565217 -0.671936759 -0.632432432 kegg kegg NA NA no no no no no no Peroxisome Hedgehog signaling pathway 0 0 -0.593822394 kegg kegg NA NA no no no no no no Phagosome Hedgehog signaling pathway -0.503478261 -0.581027668 -0.528185328 kegg kegg NA NA no no no no no no Phenylalanine metabolism Hedgehog signaling pathway 0 0.449604743 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Hedgehog signaling pathway 0.819130435 0.755928854 0.863320463 kegg kegg NA NA no no no no no no Platinum drug resistance Hedgehog signaling pathway 0 0.752964427 0.541055341 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Hedgehog signaling pathway 0 0 -0.467696268 kegg kegg NA NA no no no no no no PPAR signaling pathway Hedgehog signaling pathway -0.514782609 -0.454545455 -0.496525097 kegg kegg NA NA no no no no no no Protein export Hedgehog signaling pathway 0.432173913 0 0.592792793 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Hedgehog signaling pathway 0 0.613636364 0 kegg kegg NA NA no no no no no no Purine metabolism Hedgehog signaling pathway 0 0.480237154 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Hedgehog signaling pathway -0.419130435 0.56027668 0.402831403 kegg kegg NA NA no no no no no no Ras signaling pathway Hedgehog signaling pathway 0 0 0.603603604 yes kegg kegg NA NA no up up no no no Retinol metabolism Hedgehog signaling pathway -0.42173913 0.616600791 0 kegg kegg NA NA no no no no no no Ribosome Hedgehog signaling pathway 0.437391304 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Hedgehog signaling pathway 0.405217391 0.900197628 0.743629344 kegg kegg NA NA no no no no no no RNA degradation Hedgehog signaling pathway 0.704347826 0.548418972 0.841698842 kegg kegg NA NA no no no no no no RNA polymerase Hedgehog signaling pathway 0 0.779644269 0.517117117 kegg kegg NA NA no no no no no no Selenocompound metabolism Hedgehog signaling pathway 0 0.816205534 0.681081081 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Hedgehog signaling pathway 0.474782609 -0.424901186 0.431917632 kegg kegg NA NA no no no no no no Spliceosome Hedgehog signaling pathway 0 0.756916996 0.722779923 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Hedgehog signaling pathway -0.543478261 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Hedgehog signaling pathway 0.480869565 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Hedgehog signaling pathway -0.489565217 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Hedgehog signaling pathway 0 0 -0.598970399 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Hedgehog signaling pathway 0 0.701581028 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Hedgehog signaling pathway 0 0 0.673359073 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Hedgehog signaling pathway 0 0.590909091 0.488803089 kegg kegg NA NA no no no no no no Tyrosine metabolism Hedgehog signaling pathway 0 0.502964427 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Hedgehog signaling pathway 0 0.64229249 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Hedgehog signaling pathway 0 0.604743083 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Hedgehog signaling pathway 0 0.692687747 0.617245817 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Hedgehog signaling pathway 0 -0.678853755 -0.623423423 kegg kegg NA NA no no no no no no Wnt signaling pathway Hedgehog signaling pathway 0.730434783 0.647233202 0.831402831 kegg kegg NA NA no no no no no no 12-HEPE+blood Height+clinic 0 0.531685128 0 serum_ARA clinic 0.312 0.358 no no no no no no 12-ketoDCA+blood Height+clinic 0 0.530999412 0 serum_bileacids clinic 0.517 0.358 no no no no no no 13-HODE+blood Height+clinic 0 0 0.492307692 serum_ARA clinic 0.32 0.358 no no no no no no 16:0/16:1-PC+blood Height+clinic 0 -0.653571429 0 serum_phospholipids clinic 0.00283 0.358 up up no no no no 16:0/18:1-PC+blood Height+clinic 0.599587203 0 0 serum_phospholipids clinic 6.15E-07 0.358 up up up no no no 16:0/18:2-PC+blood Height+clinic 0.479876161 0 0 serum_phospholipids clinic 3.24E-06 0.358 no up up no no no 16:0/18:2-PI+blood Height+clinic -0.475748194 -0.660714286 0 serum_phospholipids clinic 0.269 0.358 no no no no no no 16:0/20:3-PC+blood Height+clinic 0 0 -0.41 serum_phospholipids clinic 5.43E-06 0.358 no up up no no no 16:0/20:4-PI+blood Height+clinic -0.715170279 0 -0.440769231 serum_phospholipids clinic 0.558 0.358 no no no no no no 16:0/20:5-PC+blood Height+clinic 0 0.575 0 serum_phospholipids clinic 0.628 0.358 no no no no no no 16:1/18:2-PG+blood Height+clinic 0.484004128 0 0 serum_phospholipids clinic 1.40E-08 0.358 no up up no no no 18:0-LPA+blood Height+clinic 0 0 -0.418461538 serum_phospholipids clinic 0.0725 0.358 no dn no no no no 18:0-LPC+blood Height+clinic -0.568627451 0 0 serum_phospholipids clinic 0.554 0.358 no no no no no no 18:0-LPE+blood Height+clinic -0.475748194 0 0 serum_phospholipids clinic 0.491 0.358 no no no no no no 18:0/16:0-PC+blood Height+clinic 0.572755418 0 0 serum_phospholipids clinic 9.64E-07 0.358 up up up no no no 18:0/18:1-PE+blood Height+clinic 0 -0.575 0 serum_phospholipids clinic 0.00716 0.358 up up no no no no 18:0/18:2-PC+blood Height+clinic 0.510835913 0 0 serum_phospholipids clinic 1.74E-06 0.358 no up up no no no 18:0/20:3-PC+blood Height+clinic -0.566563467 0 -0.585384615 serum_phospholipids clinic 0.0682 0.358 no up no no no no 18:0/20:3-PI+blood Height+clinic 0 -0.65 0 serum_phospholipids clinic 0.377 0.358 no no no no no no 18:0/20:4-PC+blood Height+clinic 0 0.667857143 0 serum_phospholipids clinic 0.454 0.358 no no no no no no 18:0/20:5-PC+blood Height+clinic 0 0.653571429 0 serum_phospholipids clinic 0.17 0.358 no no no no no no 18:1/18:0-PC+blood Height+clinic 0.494324045 0 0 serum_phospholipids clinic 1.83E-06 0.358 no up up no no no 18:1/18:1-PC+blood Height+clinic 0 0 -0.44 serum_phospholipids clinic 1.34E-05 0.358 no up up no no no 18:1/18:1-PE+blood Height+clinic 0 -0.725 0 serum_phospholipids clinic 1.03E-05 0.358 up up no no no no 18:1/18:2-PG+blood Height+clinic 0.481940144 0 0 serum_phospholipids clinic 5.58E-07 0.358 no up up no no no 18:1/20:4-PC+blood Height+clinic 0 0.575 0 serum_phospholipids clinic 0.582 0.358 no no no no no no 18:2-LPC+blood Height+clinic 0.488132095 0 0 serum_phospholipids clinic 0.00743 0.358 dn no up no no no 18:2/16:0-PC+blood Height+clinic 0.642930857 0 0 serum_phospholipids clinic 8.67E-05 0.358 no up up no no no 18:2/18:2-PC+blood Height+clinic 0.477812178 0 0 serum_phospholipids clinic 1.98E-05 0.358 dn up up no no no 18:2/20:4-PC+blood Height+clinic 0 0.532142857 0 serum_phospholipids clinic 0.0145 0.358 no no up no no no 18:3n3+blood Height+clinic 0 0 0.536923077 serum_fattyacid clinic 0.291 0.358 no no no no no no 18:3n6+blood Height+clinic -0.558307534 0 0 serum_fattyacid clinic 0.0463 0.358 up no dn no no no 20:2/18:0-PC+blood Height+clinic -0.529411765 0 -0.569230769 serum_phospholipids clinic 0.0427 0.358 no up no no no no 20:3/16:0-PC+blood Height+clinic 0.479876161 0 0 serum_phospholipids clinic 0.00405 0.358 no up up no no no 20:3n6+blood Height+clinic -0.630546956 -0.657142857 -0.486153846 serum_fattyacid clinic 0.0884 0.358 up no no no no no 20:4-LPC+blood Height+clinic 0 0.682142857 0 serum_phospholipids clinic 0.949 0.358 no no no no no no 20:4n6+blood Height+clinic 0 0.6 0 serum_fattyacid clinic 0.133 0.358 no no no no no no 22:6n3+blood Height+clinic -0.574819401 0 0 serum_fattyacid clinic 0.792 0.358 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine Height+clinic 0 0 -0.421538462 urine_cometabolism clinic 0.973 0.358 no no no no no no 4-hydroxybenzoic acid+urine Height+clinic 0 0.495098039 0 urine_cometabolism clinic 0.52 0.358 no no no no no no Apoptosis Height+clinic 0.522303783 0 0 kegg clinic NA 0.358 no no no no no no C-peptide Height+clinic 0 -0.626199887 -0.458212376 DM-assocaited hormones clinic 0.228 0.358 no no no no no no Cholinergic synapse Height+clinic 0 0.488311688 0 kegg clinic NA 0.358 no no no no no no Coprococcus Height+clinic -0.446640316 0 0 butyrate-producing Genus clinic 0.612 0.358 no no no no no no Cytosolic DNA-sensing pathway Height+clinic 0.514398645 0 0 kegg clinic NA 0.358 no no no no no no d18:1-18:0-SM+blood Height+clinic 0.543859649 0 0 serum_phospholipids clinic 0.97 0.358 no no no no no no d18:1-18:1-SM+blood Height+clinic 0.484004128 0 0 serum_phospholipids clinic 0.916 0.358 no no no no no no d18:1-20:1-SM+blood Height+clinic 0.539731682 0 0 serum_phospholipids clinic 0.0992 0.358 no no no no no no EPA+blood Height+clinic 0 0.653571429 0 serum_ARA clinic 0.212 0.358 no no no no no no Ethanolamine+blood Height+clinic 0.490196078 0 0 serum_aminoacids clinic 0.122 0.358 up no no no no no Gastric cancer Height+clinic -0.486166008 0 0 kegg clinic NA 0.358 no no no no no no GCDCA+stool Height+clinic -0.5 0 0 yes stool_bileacids clinic 0.0471 0.358 no dn no no no no GLCA+blood Height+clinic 0 0 0.449552064 serum_bileacids clinic 0.319 0.358 no no no no no no Glycine+blood Height+clinic 0.570691434 0 0 serum_aminoacids clinic 0.00408 0.358 dn no up no no no HDCA+blood Height+clinic 0.481869425 0.530999412 0 serum_bileacids clinic 0.483 0.358 no no no no no no Homovanillic acid+urine Height+clinic -0.504643963 0 0 urine_cometabolism clinic 0.45 0.358 no no no no no no IP-10 Height+clinic 0 -0.477192982 0 serum_cytokines clinic 0.394 0.358 no no no no no no iso-DCA+blood Height+clinic 0.581011352 0 0 serum_bileacids clinic 0.38 0.358 no no no no no no iso-LCA+blood Height+clinic 0 0.542185151 0 serum_bileacids clinic 0.507 0.358 no no no no no no L-Aspartic acid+blood Height+clinic 0.543859649 0 0 yes serum_aminoacids clinic 0.0226 0.358 up up no no no no L-Phenylalanine+blood Height+clinic 0 -0.689285714 0 yes serum_aminoacids clinic 0.0103 0.358 up up no no no no L-Proline+blood Height+clinic 0 -0.753571429 0 yes serum_aminoacids clinic 0.00265 0.358 up up no no no no L-Tryptophan+blood Height+clinic 0 -0.632142857 0 serum_aminoacids clinic 0.164 0.358 no no no no no no L-Tyrosine+blood Height+clinic 0 -0.739285714 0 yes serum_aminoacids clinic 0.00913 0.358 up up no no no no Leptin Height+clinic 0 0 -0.44171123 DM-assocaited hormones clinic 0.706 0.358 no no no no no no n6/n3+blood Height+clinic 0.510835913 0 0 serum_fattyacid clinic 0.226 0.358 no no no no no no P-hydroxyhippuric acid+urine Height+clinic -0.51496388 0 0 urine_cometabolism clinic 0.436 0.358 no no no no no no Parabacteroides Height+clinic 0 0.448898927 0 Genus clinic 4.19E-05 0.358 no up up no no no Paraprevotella Height+clinic 0 -0.540367726 0 Genus clinic 0.118 0.358 no no no no no no Pathogenic Escherichia coli infection Height+clinic 0.429700734 0 0 kegg clinic NA 0.358 no no no no no no Phenylacetic acid+stool Height+clinic 0.555882353 0 0 stool_cometabolism clinic 0.785 0.358 no no no no no no PI3K-Akt signaling pathway Height+clinic 0 0.467532468 0 yes kegg clinic NA 0.358 no up up no no no PUFA%+blood Height+clinic 0.616099071 0 0 serum_fattyacid clinic 0.0013 0.358 dn no up no no no Roseburia Height+clinic 0 -0.462016398 0 butyrate-producing Genus clinic 0.495 0.358 no no no no no no SFA%+blood Height+clinic 0.545923633 0 0 serum_fattyacid clinic 0.0236 0.358 no up no no no no TCA+stool Height+clinic 0 -0.619591585 -0.425183512 stool_bileacids clinic 0.458 0.358 no no no no no no TXB2+blood Height+clinic 0 0.61598878 0 yes serum_ARA clinic 0.0644 0.358 dn no no no no no UFA%+blood Height+clinic 0.55624355 0 0 serum_fattyacid clinic 0.0236 0.358 no dn no no no no Visfatin Height+clinic 0 0 0.455767762 DM-assocaited hormones clinic 0.0229 0.358 dn no up no no no 2-Oxocarboxylic acid metabolism Hematopoietic cell lineage 0 0.529644269 0 kegg kegg NA NA no no no no no no Adherens junction Hematopoietic cell lineage 0 0.445652174 0.455083655 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Hematopoietic cell lineage 0 0 0.443758044 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Hematopoietic cell lineage 0 0.419960474 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Hematopoietic cell lineage 0 -0.462450593 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Hematopoietic cell lineage 0.41826087 0 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Hematopoietic cell lineage 0 -0.414031621 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Hematopoietic cell lineage 0 0.492094862 0 kegg kegg NA NA no no no no no no Autophagy - animal Hematopoietic cell lineage 0 -0.510869565 0 kegg kegg NA NA no no no no no no Axon guidance Hematopoietic cell lineage -0.476521739 0 0 kegg kegg NA NA no up up no no no beta-Alanine metabolism Hematopoietic cell lineage 0.451304348 0.751976285 0.726640927 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Hematopoietic cell lineage 0 0.56027668 0.624195624 kegg kegg NA NA no no no no no no Butanoate metabolism Hematopoietic cell lineage 0 0.708498024 0.471299871 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Hematopoietic cell lineage 0 0 -0.454568855 kegg kegg NA NA no no no no no no cAMP signaling pathway Hematopoietic cell lineage -0.529565217 -0.606719368 -0.595109395 yes kegg kegg NA NA no up up no no no Carbon metabolism Hematopoietic cell lineage 0 0.701581028 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Hematopoietic cell lineage -0.453913043 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Hematopoietic cell lineage 0 0.698616601 0 kegg kegg NA NA no no no no no no Clostridium Hematopoietic cell lineage 0 0.566455843 0 Genus kegg 0.925 NA no no no no no no Cysteine and methionine metabolism Hematopoietic cell lineage 0 0.659090909 0.400772201 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Hematopoietic cell lineage 0 0 0.437837838 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Hematopoietic cell lineage -0.584347826 -0.475296443 -0.51994852 kegg kegg NA NA no no no no no no DNA replication Hematopoietic cell lineage 0 0.446640316 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Hematopoietic cell lineage 0 0.599802372 0.576061776 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Hematopoietic cell lineage 0 0.628458498 0 kegg kegg NA NA no no no no no no Fatty acid degradation Hematopoietic cell lineage 0.424347826 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Hematopoietic cell lineage 0 0.752964427 0.676447876 kegg kegg NA NA no no no no no no Fatty acid metabolism Hematopoietic cell lineage 0.424347826 0 0 kegg kegg NA NA no no no no no no Ferroptosis Hematopoietic cell lineage 0 -0.552371542 0 kegg kegg NA NA no no no no no no Focal adhesion Hematopoietic cell lineage 0 0.590909091 0.524066924 kegg kegg NA NA no up up no no no Gap junction Hematopoietic cell lineage 0 -0.658102767 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Hematopoietic cell lineage 0 0.734189723 0.570913771 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Hematopoietic cell lineage 0 -0.506916996 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Hematopoietic cell lineage 0 0 -0.487516088 kegg kegg NA NA no no no no no no Hippo signaling pathway Hematopoietic cell lineage 0 0.462450593 0.516087516 kegg kegg NA NA no no no no no no Histidine metabolism Hematopoietic cell lineage 0.42173913 0 0.585585586 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Hematopoietic cell lineage 0 -0.481225296 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Hematopoietic cell lineage 0 -0.727272727 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Hematopoietic cell lineage 0 0.428853755 0.436036036 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Hematopoietic cell lineage 0 0.684782609 0.584041184 kegg kegg NA NA no no no no no no Mismatch repair Hematopoietic cell lineage 0 0.437747036 0 kegg kegg NA NA no no no no no no Necroptosis Hematopoietic cell lineage 0 -0.520750988 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Hematopoietic cell lineage 0 -0.469367589 -0.485456885 kegg kegg NA NA no no no no no no Nitrogen metabolism Hematopoietic cell lineage 0 -0.496047431 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Hematopoietic cell lineage 0 0.756916996 0 kegg kegg NA NA no no no no no no Oocyte meiosis Hematopoietic cell lineage 0 0.627470356 0 kegg kegg NA NA no no no no no no p53 signaling pathway Hematopoietic cell lineage 0 -0.445652174 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Hematopoietic cell lineage 0 0.586956522 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Hematopoietic cell lineage 0 0.665019763 0.495495495 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Hematopoietic cell lineage 0 -0.699604743 -0.421364221 kegg kegg NA NA no up up no no no Primary bile acid biosynthesis Hematopoietic cell lineage 0 0.722332016 0.611583012 kegg kegg NA NA no no no no no no Propanoate metabolism Hematopoietic cell lineage 0 0.663043478 0 kegg kegg NA NA no no no no no no Proteasome Hematopoietic cell lineage 0 0.624505929 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Hematopoietic cell lineage 0.5 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Hematopoietic cell lineage 0 0.559288538 0 kegg kegg NA NA no no no no no no Retinol metabolism Hematopoietic cell lineage 0 0.422924901 0.402316602 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Hematopoietic cell lineage 0 -0.481225296 -0.516344916 kegg kegg NA NA no no no no no no Steroid biosynthesis Hematopoietic cell lineage 0 0.517786561 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Hematopoietic cell lineage 0 0.635375494 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Hematopoietic cell lineage 0 -0.520750988 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Hematopoietic cell lineage 0 0.490118577 0 kegg kegg NA NA no no no no no no Thiamine metabolism Hematopoietic cell lineage 0 0.461462451 0 kegg kegg NA NA no no no no no no Tight junction Hematopoietic cell lineage 0 0.453557312 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Hematopoietic cell lineage 0 0 -0.461518662 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Hematopoietic cell lineage 0.420869565 0.781620553 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Hematopoietic cell lineage 0 0.539525692 0.517631918 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Hematopoietic cell lineage 0 0.495059289 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Hematopoietic cell lineage 0 0.632411067 0.547747748 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Hepatitis B -0.577391304 -0.563241107 0 kegg kegg NA NA no no no no no no ABC transporters Hepatitis B 0 0.479249012 0 kegg kegg NA NA no up up no no no Adherens junction Hepatitis B -0.58 -0.834980237 -0.430888031 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Hepatitis B 0 0.633399209 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Hepatitis B 0 -0.624505929 0 kegg kegg NA NA no no up no no no African trypanosomiasis Hepatitis B 0.427826087 0.526679842 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Hepatitis B 0.477391304 0.851778656 0.659202059 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Hepatitis B 0.463478261 0.830039526 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Hepatitis B 0 -0.572134387 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Hepatitis B 0.608695652 0.483201581 0.524581725 kegg kegg NA NA no no no no no no Alistipes Hepatitis B -0.455026173 0 0 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism Hepatitis B 0 0.580039526 0 kegg kegg NA NA no no no no no no Alzheimer disease Hepatitis B 0 -0.805335968 0 kegg kegg NA NA no no no no no no Amoebiasis Hepatitis B 0 0.646245059 0 kegg kegg NA NA no no no no no no Amphetamine addiction Hepatitis B 0 -0.68972332 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Hepatitis B -0.460869565 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Hepatitis B 0 -0.825098814 -0.405405405 kegg kegg NA NA no no no no no no Anaerostipes Hepatitis B 0 0 -0.400314721 butyrate-producing Genus kegg 0.568 NA no no no no no no Apelin signaling pathway Hepatitis B 0 -0.76284585 0 kegg kegg NA NA no no no no no no Apoptosis Hepatitis B 0 0.70256917 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Hepatitis B 0 0.450592885 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Hepatitis B -0.673913043 0 -0.435778636 kegg kegg NA NA no no no no no no Arginine and proline metabolism Hepatitis B 0 0.821146245 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Hepatitis B 0 0.77173913 0 kegg kegg NA NA no no no no no no Autophagy - animal Hepatitis B 0.853043478 0.966403162 0.47979408 kegg kegg NA NA no no no no no no Autophagy - other Hepatitis B 0.694782609 0.617588933 0.485199485 kegg kegg NA NA no no no no no no Axon guidance Hepatitis B 0.410434783 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Hepatitis B 0.554782609 0.843873518 0.706563707 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Hepatitis B -0.516521739 -0.683794466 -0.536422136 kegg kegg NA NA no no no no no no beta-Alanine metabolism Hepatitis B -0.466086957 0 -0.64967825 kegg kegg NA NA no no no no no no Bifidobacterium Hepatitis B 0 -0.42843123 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Bile secretion Hepatitis B 0 -0.41798419 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Hepatitis B 0 0.480237154 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Hepatitis B -0.707826087 -0.451581028 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Hepatitis B 0 0 -0.611840412 kegg kegg NA NA no no no no no no Butanoate metabolism Hepatitis B -0.464347826 -0.686758893 -0.687258687 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Hepatitis B 0.84173913 0.877470356 0.882882883 kegg kegg NA NA no no no no no no Calcium signaling pathway Hepatitis B 0 -0.468379447 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Hepatitis B 0 0.429841897 0.54980695 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Hepatitis B 0.804347826 0.657114625 0.453281853 kegg kegg NA NA no no no no no no Carbon metabolism Hepatitis B -0.436521739 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Hepatitis B 0 -0.782608696 0 kegg kegg NA NA no no up no no no Cell cycle Hepatitis B 0 -0.436758893 0 kegg kegg NA NA no no no no no no Cellular senescence Hepatitis B 0 0.445652174 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Hepatitis B 0.611304348 0.571146245 0 kegg kegg NA NA no no no no no no Chagas disease Hepatitis B 0.590434783 0.792490119 0.49009009 kegg kegg NA NA no no no no no no Chemokine signaling pathway Hepatitis B 0.436521739 0.522727273 0 kegg kegg NA NA no no no no no no Cholinergic synapse Hepatitis B 0.635652174 0 0.473101673 kegg kegg NA NA no no no no no no Circadian entrainment Hepatitis B -0.5 -0.738142292 0 kegg kegg NA NA no up up no no no Circadian rhythm Hepatitis B 0.506956522 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Hepatitis B -0.471304348 -0.71541502 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Hepatitis B 0 0 -0.405662806 kegg kegg NA NA no no no no no no Collinsella Hepatitis B 0 0 -0.446782362 Genus kegg 0.128 NA no no no no no no Complement and coagulation cascades Hepatitis B 0 0.480237154 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Hepatitis B 0 -0.70256917 -0.439124839 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Hepatitis B 0 0 -0.476190476 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Hepatitis B 0 0.508893281 0 kegg kegg NA NA no no no no no no DNA replication Hepatitis B 0 -0.683794466 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Hepatitis B 0 -0.710474308 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Hepatitis B 0 -0.815217391 -0.498841699 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Hepatitis B -0.522608696 -0.849802372 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Hepatitis B 0 -0.610671937 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Hepatitis B -0.433043478 -0.662055336 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Hepatitis B 0.474782609 0.704545455 0.455598456 kegg kegg NA NA no no no no no no ErbB signaling pathway Hepatitis B 0.622608696 0.638339921 0.633204633 kegg kegg NA NA no no no no no no Estrogen signaling pathway Hepatitis B 0 -0.646245059 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Hepatitis B 0.47826087 0.800395257 0 kegg kegg NA NA no no no no no no Fatty acid degradation Hepatitis B 0 0.640316206 0 kegg kegg NA NA no no no no no no Fatty acid elongation Hepatitis B -0.416521739 -0.428853755 -0.678507079 kegg kegg NA NA no no no no no no Fatty acid metabolism Hepatitis B 0 0.543478261 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Hepatitis B 0.515652174 0.802371542 0.501415701 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Hepatitis B 0 0.476284585 0 kegg kegg NA NA no no no no no no Focal adhesion Hepatitis B -0.565217391 -0.816205534 -0.425997426 kegg kegg NA NA no up up no no no Folate biosynthesis Hepatitis B 0 -0.428853755 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Hepatitis B 0.659130435 0.755928854 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Hepatitis B 0 0.557312253 0 kegg kegg NA NA no no no no no no GABAergic synapse Hepatitis B 0 0.609683794 0 kegg kegg NA NA no up up no no no Galactose metabolism Hepatitis B 0 0.601778656 0 kegg kegg NA NA no no no no no no Gap junction Hepatitis B -0.473043478 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Hepatitis B -0.687826087 -0.883399209 -0.404890605 kegg kegg NA NA no no no no no no Glucagon signaling pathway Hepatitis B 0 -0.687747036 0 kegg kegg NA NA no no no no no no Glutathione metabolism Hepatitis B -0.713043478 -0.691699605 -0.462290862 kegg kegg NA NA no no no no no no Glycerolipid metabolism Hepatitis B 0 0.606719368 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Hepatitis B 0 0.5256917 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Hepatitis B -0.7 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Hepatitis B -0.422608696 -0.696640316 -0.546718147 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Hepatitis B 0.416521739 0.871541502 0.41956242 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Hepatitis B -0.605217391 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Hepatitis B 0 0.449604743 0.430888031 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Hepatitis B 0 0.773715415 0 kegg kegg NA NA no no no no no no GnRH secretion Hepatitis B 0.639130435 0.660079051 0.508622909 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Hepatitis B 0 0.453557312 0.594851995 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Hepatitis B 0 0 -0.467953668 kegg kegg NA NA no no no no no no Hepatitis C Hepatitis B 0.766956522 0.634387352 0.874646075 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Hepatitis B 0 -0.657114625 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Hepatitis B -0.68173913 -0.849802372 -0.427027027 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Hepatitis B 0.529565217 0.754940711 0 kegg kegg NA NA no no no no no no Huntington disease Hepatitis B 0 -0.805335968 -0.401544402 kegg kegg NA NA no no no no no no IL-17 signaling pathway Hepatitis B 0.640869565 0.533596838 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Hepatitis B 0 -0.758893281 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Hepatitis B 0 0.500988142 0 kegg kegg NA NA no no no no no no Insulin resistance Hepatitis B 0.805217391 0.876482213 0.831917632 kegg kegg NA NA no no no no no no Insulin signaling pathway Hepatitis B 0 -0.684782609 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Hepatitis B 0.415652174 0.867588933 0 kegg kegg NA NA no no no no no no Lachnospira Hepatitis B 0 -0.529775158 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Leukocyte transendothelial migration Hepatitis B 0 -0.420948617 0 kegg kegg NA NA no no no no no no Long-term potentiation Hepatitis B 0 -0.498023715 0 kegg kegg NA NA no no up no no no Longevity regulating pathway - multiple species Hepatitis B 0 0 -0.507850708 kegg kegg NA NA no no no no no no Malaria Hepatitis B -0.447826087 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Hepatitis B 0.523478261 0.546442688 0 kegg kegg NA NA no no no no no no Melanogenesis Hepatitis B -0.446086957 -0.749011858 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Hepatitis B -0.437391304 -0.81027668 -0.538996139 kegg kegg NA NA no no no no no no Mismatch repair Hepatitis B 0 -0.575098814 -0.581209781 kegg kegg NA NA no no no no no no Mitophagy - animal Hepatitis B 0 -0.493083004 0 kegg kegg NA NA no no no no no no Morphine addiction Hepatitis B 0 -0.503952569 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Hepatitis B 0 -0.454545455 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Hepatitis B 0 -0.586956522 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Hepatitis B 0 0.432806324 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Hepatitis B 0 -0.687747036 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Hepatitis B 0.667826087 0.716403162 0.787129987 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Hepatitis B 0.768695652 0.960474308 0.865122265 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Hepatitis B 0.437391304 0.76284585 0 kegg kegg NA NA no no no no no no Nicotine addiction Hepatitis B 0 0 0.471557272 kegg kegg NA NA no up up no no no Nitrogen metabolism Hepatitis B 0 0.719367589 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Hepatitis B 0.519130435 0.895256917 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Hepatitis B 0 -0.710474308 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Hepatitis B 0 -0.511857708 -0.624195624 kegg kegg NA NA no no no no no no Notch signaling pathway Hepatitis B 0.408695652 0.504940711 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Hepatitis B 0 -0.565217391 -0.485714286 kegg kegg NA NA no no no no no no One carbon pool by folate Hepatitis B 0 -0.593873518 0 kegg kegg NA NA no no no no no no Oocyte meiosis Hepatitis B 0 -0.661067194 0 kegg kegg NA NA no no no no no no Oscillospira Hepatitis B 0 0.414031621 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Hepatitis B 0.492173913 0.778656126 0.47027027 kegg kegg NA NA no no no no no no Other glycan degradation Hepatitis B 0 0.552371542 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Hepatitis B -0.508695652 0 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Hepatitis B 0 -0.804347826 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Hepatitis B -0.586086957 -0.583003953 -0.468468468 kegg kegg NA NA no no no no no no p53 signaling pathway Hepatitis B 0.506956522 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Hepatitis B 0 -0.662055336 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Hepatitis B 0.508695652 0.695652174 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Hepatitis B 0 -0.51284585 0 kegg kegg NA NA no no no no no no Parkinson disease Hepatitis B 0 -0.729249012 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Hepatitis B 0 -0.713438735 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Hepatitis B -0.509565217 -0.714426877 0 kegg kegg NA NA no no no no no no Peroxisome Hepatitis B 0 0.654150198 0 kegg kegg NA NA no no no no no no Pertussis Hepatitis B 0 0.537549407 0 kegg kegg NA NA no no dn no no no Phenylalanine metabolism Hepatitis B -0.71826087 -0.685770751 -0.484427284 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Hepatitis B 0 0.713438735 0.516602317 kegg kegg NA NA no up up no no no Phototransduction Hepatitis B 0 -0.734189723 -0.501930502 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Hepatitis B 0.408695652 0 0 yes kegg kegg NA NA no up up no no no Platelet activation Hepatitis B -0.668695652 -0.753952569 0 kegg kegg NA NA no no no no no no Platinum drug resistance Hepatitis B 0.45826087 0 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Hepatitis B -0.642608696 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Hepatitis B 0 0.735177866 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Hepatitis B 0 -0.464426877 -0.523037323 kegg kegg NA NA no no no no no no Prion disease Hepatitis B 0 -0.840909091 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Hepatitis B 0.68173913 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Hepatitis B 0.607826087 0.777667984 0.718404118 kegg kegg NA NA no no no no no no Propanoate metabolism Hepatitis B 0 -0.675889328 -0.478507079 kegg kegg NA NA no no no no no no Proteasome Hepatitis B 0 -0.696640316 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Hepatitis B 0 0.672924901 0 yes kegg kegg NA NA no up up no no no Protein export Hepatitis B 0 -0.764822134 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Hepatitis B 0 -0.643280632 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Hepatitis B 0 -0.71541502 0 kegg kegg NA NA no no no no no no Purine metabolism Hepatitis B -0.503478261 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Hepatitis B 0 -0.643280632 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Hepatitis B 0 -0.756916996 -0.628314028 kegg kegg NA NA no no no no no no Rap1 signaling pathway Hepatitis B -0.424347826 -0.588932806 0 kegg kegg NA NA no no no no no no Ras signaling pathway Hepatitis B 0 -0.699604743 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Hepatitis B -0.515652174 -0.657114625 -0.629343629 kegg kegg NA NA no no no no no no Relaxin signaling pathway Hepatitis B 0 0.559288538 0.547747748 kegg kegg NA NA no no no no no no Renin secretion Hepatitis B -0.646086957 -0.849802372 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Hepatitis B 0 0.495059289 0 kegg kegg NA NA no no no no no no Retinol metabolism Hepatitis B 0 -0.421936759 -0.400514801 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Hepatitis B 0 -0.849802372 0 kegg kegg NA NA no no up no no no Ribosome Hepatitis B 0 -0.755928854 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Hepatitis B 0.900869565 0.955533597 0.877220077 kegg kegg NA NA no no no no no no RNA degradation Hepatitis B 0 -0.625494071 0 kegg kegg NA NA no no no no no no RNA polymerase Hepatitis B 0 -0.540513834 0 kegg kegg NA NA no no no no no no RNA transport Hepatitis B 0 -0.522727273 0 kegg kegg NA NA no no no no no no Roseburia Hepatitis B -0.504347826 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Salivary secretion Hepatitis B -0.502608696 -0.545454545 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Hepatitis B 0.420869565 0 0 kegg kegg NA NA no no no no no no Shigellosis Hepatitis B 0 -0.509881423 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Hepatitis B 0.573043478 0 0.487258687 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Hepatitis B 0 0.738142292 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Hepatitis B 0.595652174 0.437747036 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Hepatitis B 0.60173913 0 0 kegg kegg NA NA no no no no no no Spliceosome Hepatitis B 0.451304348 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Hepatitis B 0 0.717391304 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Hepatitis B 0 -0.556324111 -0.47979408 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Hepatitis B -0.463478261 -0.517786561 0 kegg kegg NA NA no no no no no no Sulfur metabolism Hepatitis B -0.64 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Hepatitis B 0 -0.486166008 -0.434749035 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Hepatitis B 0.69826087 0.720355731 0 kegg kegg NA NA no no no no no no Taste transduction Hepatitis B 0 -0.43972332 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Hepatitis B 0.453913043 0.625494071 0.406692407 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Hepatitis B 0 -0.706521739 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Hepatitis B 0 0.440711462 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Hepatitis B 0 0.506916996 0 kegg kegg NA NA no no no no no no Thermogenesis Hepatitis B 0 -0.847826087 -0.42007722 kegg kegg NA NA no no no no no no Thiamine metabolism Hepatitis B 0 -0.53458498 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Hepatitis B 0 -0.730237154 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Hepatitis B -0.573043478 0 0 kegg kegg NA NA no no no no no no Tight junction Hepatitis B -0.645217391 -0.763833992 -0.671299871 kegg kegg NA NA no no no no no no TNF signaling pathway Hepatitis B 0.711304348 0.880434783 0.757528958 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Hepatitis B 0.744347826 0.862648221 0.621879022 yes kegg kegg NA NA no no no no no no Toxoplasmosis Hepatitis B 0 0.454545455 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Hepatitis B -0.465217391 -0.556324111 -0.462290862 kegg kegg NA NA no up no no no no Type II diabetes mellitus Hepatitis B 0.74 0.830039526 0.595109395 kegg kegg NA NA no no no no no no Tyrosine metabolism Hepatitis B -0.620869565 -0.711462451 -0.805662806 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Hepatitis B -0.414782609 -0.501976285 -0.464092664 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Hepatitis B 0 -0.559288538 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Hepatitis B 0 -0.621541502 -0.594594595 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Hepatitis B 0 -0.494071146 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Hepatitis B 0 -0.820158103 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Hepatitis B 0 -0.710474308 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Hepatitis B 0.66 0.56916996 0.474646075 kegg kegg NA NA no no no no no no Vibrio cholerae infection Hepatitis B -0.632173913 -0.785573123 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Hepatitis B 0 -0.663043478 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Hepatitis C -0.622608696 0 -0.406949807 kegg kegg NA NA no no no no no no Adherens junction Hepatitis C 0 -0.448616601 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Hepatitis C 0 0.65513834 0 kegg kegg NA NA no no no no no no African trypanosomiasis Hepatitis C 0.456521739 0 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Hepatitis C 0 0 0.504247104 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Hepatitis C 0 0.423913043 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Hepatitis C 0.593043478 0.420948617 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Hepatitis C 0 -0.414031621 -0.51969112 kegg kegg NA NA no no no no no no Amphetamine addiction Hepatitis C 0 -0.53458498 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Hepatitis C -0.470434783 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Hepatitis C -0.408695652 -0.544466403 0 kegg kegg NA NA no no no no no no Apoptosis Hepatitis C 0 0.586956522 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Hepatitis C -0.503478261 0 -0.428571429 kegg kegg NA NA no no no no no no Arginine and proline metabolism Hepatitis C 0 0.43083004 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Hepatitis C 0 0.42687747 0 kegg kegg NA NA no no no no no no Autophagy - animal Hepatitis C 0.562608696 0.630434783 0 kegg kegg NA NA no no no no no no Autophagy - other Hepatitis C 0.56173913 0.535573123 0.406177606 kegg kegg NA NA no no no no no no Axon guidance Hepatitis C 0.606086957 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Hepatitis C 0.433913043 0.709486166 0.544658945 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Hepatitis C 0 0 -0.51969112 kegg kegg NA NA no no no no no no beta-Alanine metabolism Hepatitis C -0.567826087 -0.494071146 -0.652509653 kegg kegg NA NA no no no no no no Bile secretion Hepatitis C 0 -0.433794466 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Hepatitis C -0.671304348 -0.488142292 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Hepatitis C 0 -0.565217391 -0.61003861 kegg kegg NA NA no no no no no no Butanoate metabolism Hepatitis C -0.566086957 -0.536561265 -0.658687259 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Hepatitis C 0.806086957 0.788537549 0.785328185 kegg kegg NA NA no no no no no no Calcium signaling pathway Hepatitis C 0 0 0.460746461 kegg kegg NA NA no up up no no no cAMP signaling pathway Hepatitis C 0.6 0.585968379 0.643758044 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Hepatitis C 0.609565217 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Hepatitis C -0.446086957 0 -0.463835264 kegg kegg NA NA no no no no no no Cellular senescence Hepatitis C 0 0.5 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Hepatitis C 0.529565217 0 0 kegg kegg NA NA no no no no no no Chagas disease Hepatitis C 0.530434783 0.649209486 0.561389961 kegg kegg NA NA no no no no no no Chemokine signaling pathway Hepatitis C 0.477391304 0.414031621 0 kegg kegg NA NA no no no no no no Cholesterol metabolism Hepatitis C 0 0.427865613 0 yes kegg kegg NA NA no no up no no no Cholinergic synapse Hepatitis C 0.552173913 0 0 kegg kegg NA NA no no no no no no Circadian entrainment Hepatitis C 0 -0.796442688 0 kegg kegg NA NA no up up no no no Circadian rhythm Hepatitis C 0.49826087 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Hepatitis C -0.466956522 -0.502964427 -0.421879022 kegg kegg NA NA no no no no no no Cocaine addiction Hepatitis C 0 0 0.428571429 kegg kegg NA NA no no no no no no Collecting duct acid secretion Hepatitis C 0 -0.517786561 -0.425482625 kegg kegg NA NA no no no no no no Cushing syndrome Hepatitis C 0 0 0.438610039 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Hepatitis C 0 -0.443675889 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Hepatitis C 0 0.875494071 0.461776062 kegg kegg NA NA no no no no no no DNA replication Hepatitis C 0 -0.566205534 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Hepatitis C 0 -0.636363636 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Hepatitis C 0 -0.576086957 -0.581209781 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Hepatitis C -0.432173913 -0.494071146 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Hepatitis C 0 0.633399209 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Hepatitis C 0.413913043 0 0.487001287 kegg kegg NA NA no no no no no no Estrogen signaling pathway Hepatitis C 0 -0.706521739 0 kegg kegg NA NA no no no no no no Fatty acid elongation Hepatitis C 0 -0.429841897 -0.662290862 kegg kegg NA NA no no no no no no Fatty acid metabolism Hepatitis C 0 0 -0.409009009 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Hepatitis C 0.405217391 0.485177866 0 kegg kegg NA NA no no no no no no Focal adhesion Hepatitis C 0 -0.520750988 0 kegg kegg NA NA no up up no no no Gastric acid secretion Hepatitis C 0 -0.57312253 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Hepatitis C 0 -0.445652174 0 kegg kegg NA NA no no no no no no Glutathione metabolism Hepatitis C -0.450434783 -0.415019763 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Hepatitis C -0.591304348 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Hepatitis C -0.443478261 0 -0.593564994 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Hepatitis C 0 0.415019763 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Hepatitis C -0.60173913 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Hepatitis C 0 0.422924901 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Hepatitis C 0 0.461462451 0 kegg kegg NA NA no no no no no no GnRH secretion Hepatitis C 0.451304348 0.428853755 0 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Hepatitis C 0 0 0.620592021 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Hepatitis C -0.532173913 0 -0.44041184 kegg kegg NA NA no no no no no no Hippo signaling pathway Hepatitis C 0 -0.454545455 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Hepatitis C 0.405217391 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Hepatitis C 0 0 -0.465379665 kegg kegg NA NA no no no no no no IL-17 signaling pathway Hepatitis C 0.548695652 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Hepatitis C 0 -0.513833992 0 kegg kegg NA NA no no no no no no Insulin resistance Hepatitis C 0.643478261 0.712450593 0.714028314 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Hepatitis C 0 0.420948617 0 kegg kegg NA NA no no no no no no Long-term potentiation Hepatitis C 0.469565217 0 0 kegg kegg NA NA no no up no no no Malaria Hepatitis C -0.459130435 0.463438735 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Hepatitis C 0 -0.48715415 0 kegg kegg NA NA no up no no no no Melanogenesis Hepatitis C 0 -0.416007905 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Hepatitis C 0 -0.597826087 -0.612097812 kegg kegg NA NA no no no no no no Mismatch repair Hepatitis C 0 -0.598814229 -0.487516088 kegg kegg NA NA no no no no no no Morphine addiction Hepatitis C 0 -0.479249012 0 kegg kegg NA NA no up up no no no Neurotrophin signaling pathway Hepatitis C 0.807826087 0.907114625 0.688545689 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Hepatitis C 0 0.654150198 0.766023166 kegg kegg NA NA no no no no no no Nicotine addiction Hepatitis C 0 0 0.446332046 kegg kegg NA NA no up up no no no NOD-like receptor signaling pathway Hepatitis C 0 0.674901186 0.419047619 kegg kegg NA NA no no no no no no Non-homologous end-joining Hepatitis C -0.446086957 -0.48715415 -0.533590734 kegg kegg NA NA no no no no no no Nucleotide excision repair Hepatitis C 0 -0.60770751 -0.408494208 kegg kegg NA NA no no no no no no One carbon pool by folate Hepatitis C 0 -0.709486166 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Hepatitis C 0 0.5 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Hepatitis C 0 -0.447628458 -0.43989704 kegg kegg NA NA no no no no no no Pancreatic secretion Hepatitis C 0 -0.419960474 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Hepatitis C 0 -0.440711462 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Hepatitis C -0.650434783 -0.588932806 -0.424710425 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Hepatitis C 0 0 0.402316602 kegg kegg NA NA no up up no no no Phototransduction Hepatitis C 0 -0.443675889 -0.446074646 kegg kegg NA NA no no no no no no Platelet activation Hepatitis C 0 -0.549407115 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Hepatitis C -0.575652174 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Hepatitis C 0 0.666007905 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Hepatitis C -0.407826087 -0.470355731 -0.58018018 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Hepatitis C 0.494782609 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Hepatitis C 0.5 0.48715415 0.66048906 kegg kegg NA NA no no no no no no Propanoate metabolism Hepatitis C 0 -0.423913043 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Hepatitis C 0 -0.522727273 0 kegg kegg NA NA no no no no no no Purine metabolism Hepatitis C -0.593913043 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Hepatitis C 0 -0.714426877 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Hepatitis C 0 -0.466403162 -0.467696268 kegg kegg NA NA no no no no no no Ras signaling pathway Hepatitis C 0 -0.509881423 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Hepatitis C 0 -0.489130435 -0.549292149 kegg kegg NA NA no no no no no no Relaxin signaling pathway Hepatitis C 0.479130435 0.559288538 0.578893179 kegg kegg NA NA no no no no no no Renin secretion Hepatitis C 0 -0.598814229 0 kegg kegg NA NA no no no no no no Retinol metabolism Hepatitis C 0 -0.723320158 -0.525353925 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Hepatitis C 0.75826087 0.739130435 0.846846847 kegg kegg NA NA no no no no no no Salivary secretion Hepatitis C 0 -0.636363636 0 kegg kegg NA NA no no no no no no Sarcina Hepatitis C 0 0.444554224 0 Genus kegg 0.0703 NA no no no no no no Signaling pathways regulating pluripotency of stem cells Hepatitis C 0.5 0 0.468211068 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Hepatitis C 0.636521739 0.606719368 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Hepatitis C 0.46173913 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Hepatitis C 0 -0.663043478 -0.538223938 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Hepatitis C 0 -0.755928854 0 kegg kegg NA NA no no no no no no Sulfur metabolism Hepatitis C -0.556521739 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Hepatitis C 0 -0.597826087 -0.464350064 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Hepatitis C 0.737391304 0.729249012 0.459459459 kegg kegg NA NA no no no no no no Taste transduction Hepatitis C 0 -0.557312253 0 kegg kegg NA NA no no up no no no Th1 and Th2 cell differentiation Hepatitis C 0 0.546442688 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Hepatitis C 0 0.662055336 0 kegg kegg NA NA no no no no no no Tight junction Hepatitis C 0 -0.429841897 -0.66975547 kegg kegg NA NA no no no no no no TNF signaling pathway Hepatitis C 0.674782609 0.793478261 0.699099099 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Hepatitis C 0.592173913 0.707509881 0.555984556 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Hepatitis C -0.593043478 -0.585968379 -0.526383526 kegg kegg NA NA no up no no no no Type II diabetes mellitus Hepatitis C 0.586956522 0.446640316 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Hepatitis C -0.609565217 -0.76284585 -0.723809524 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Hepatitis C -0.467826087 -0.640316206 -0.413642214 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Hepatitis C -0.49826087 -0.619565217 -0.612612613 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Hepatitis C 0 -0.4743083 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Hepatitis C 0 -0.500988142 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Hepatitis C 0.596521739 0.460474308 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Hepatitis C 0 -0.546442688 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Hepatitis C 0 -0.445652174 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Hepatocellular carcinoma 0 0.470355731 0 kegg kegg NA NA no no no no no no ABC transporters Hepatocellular carcinoma 0 -0.496047431 0 kegg kegg NA NA no up up no no no Adherens junction Hepatocellular carcinoma 0.920869565 0.936758893 0.917889318 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Hepatocellular carcinoma 0 -0.524703557 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Hepatocellular carcinoma 0 0.451581028 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Hepatocellular carcinoma 0 -0.522727273 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Hepatocellular carcinoma 0 -0.706521739 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Hepatocellular carcinoma 0 -0.489130435 0 kegg kegg NA NA no no no no no no Alzheimer disease Hepatocellular carcinoma 0 0.600790514 0.514800515 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Hepatocellular carcinoma 0 0.626482213 0.642471042 kegg kegg NA NA no no no no no no Apelin signaling pathway Hepatocellular carcinoma -0.525217391 0 0 kegg kegg NA NA no no no no no no Apoptosis Hepatocellular carcinoma 0.443478261 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Hepatocellular carcinoma -0.572173913 -0.531620553 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Hepatocellular carcinoma 0 -0.608695652 -0.43037323 kegg kegg NA NA no up no no no no Arginine biosynthesis Hepatocellular carcinoma 0 -0.665019763 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Hepatocellular carcinoma 0 0.418972332 0 kegg kegg NA NA no no no no no no Autophagy - animal Hepatocellular carcinoma -0.602608696 -0.781620553 0 kegg kegg NA NA no no no no no no Autophagy - other Hepatocellular carcinoma -0.827826087 -0.690711462 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Hepatocellular carcinoma 0 -0.43083004 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Hepatocellular carcinoma 0.836521739 0.838932806 0.830888031 kegg kegg NA NA no no no no no no Basal transcription factors Hepatocellular carcinoma -0.687826087 0 0 kegg kegg NA NA no no no no no no Base excision repair Hepatocellular carcinoma -0.595652174 0 0 kegg kegg NA NA no no no no no no Bifidobacterium Hepatocellular carcinoma 0 0.471026704 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Bile secretion Hepatocellular carcinoma 0 0.437747036 0 kegg kegg NA NA no no no no no no Bladder cancer Hepatocellular carcinoma 0 -0.495059289 0 kegg kegg NA NA no no no no no no Breast cancer Hepatocellular carcinoma 0 -0.548418972 0 kegg kegg NA NA no no no no no no Butyricicoccus Hepatocellular carcinoma -0.450342006 0 0 butyrate-producing Genus kegg 0.852 NA no no no no no no C-type lectin receptor signaling pathway Hepatocellular carcinoma 0 -0.522727273 -0.434491634 kegg kegg NA NA no no no no no no Calcium signaling pathway Hepatocellular carcinoma 0 0.535573123 0 kegg kegg NA NA no up up no no no Cardiac muscle contraction Hepatocellular carcinoma 0 0.647233202 0.616216216 kegg kegg NA NA no no up no no no Chagas disease Hepatocellular carcinoma 0 -0.480237154 0 kegg kegg NA NA no no no no no no Circadian entrainment Hepatocellular carcinoma 0 0.566205534 0 kegg kegg NA NA no up up no no no Circadian rhythm Hepatocellular carcinoma -0.487826087 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Hepatocellular carcinoma 0 0.446640316 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Hepatocellular carcinoma 0 0 0.48005148 kegg kegg NA NA no no no no no no Dopaminergic synapse Hepatocellular carcinoma 0 0.476284585 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Hepatocellular carcinoma 0 0.544466403 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Hepatocellular carcinoma 0 0.660079051 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Hepatocellular carcinoma -0.457391304 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Hepatocellular carcinoma 0 0.496047431 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Hepatocellular carcinoma 0 -0.601778656 0 kegg kegg NA NA no no no no no no Fatty acid degradation Hepatocellular carcinoma 0 -0.617588933 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Hepatocellular carcinoma 0 -0.606719368 0 kegg kegg NA NA no no no no no no Focal adhesion Hepatocellular carcinoma 0.846086957 0.858695652 0.846589447 kegg kegg NA NA no up up no no no Folate biosynthesis Hepatocellular carcinoma 0 0.541501976 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Hepatocellular carcinoma 0 -0.679841897 0 kegg kegg NA NA no no no no no no GABAergic synapse Hepatocellular carcinoma 0 -0.591897233 0 kegg kegg NA NA no up up no no no Gastric acid secretion Hepatocellular carcinoma 0.851304348 0.907114625 0.813384813 kegg kegg NA NA no no no no no no Glycerolipid metabolism Hepatocellular carcinoma 0 -0.483201581 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Hepatocellular carcinoma 0 -0.538537549 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Hepatocellular carcinoma 0 0.459486166 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Hepatocellular carcinoma 0 -0.511857708 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Hepatocellular carcinoma 0.470434783 0.441699605 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Hepatocellular carcinoma 0 -0.660079051 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Hepatocellular carcinoma 0 0 0.515572716 kegg kegg NA NA no no no no no no Hepatitis B Hepatocellular carcinoma -0.459130435 -0.756916996 0 kegg kegg NA NA no no no no no no Hepatitis C Hepatocellular carcinoma 0 -0.432806324 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Hepatocellular carcinoma -0.594782609 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Hepatocellular carcinoma 0.868695652 0.920948617 0.92046332 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Hepatocellular carcinoma 0 -0.522727273 0 kegg kegg NA NA no no no no no no Homologous recombination Hepatocellular carcinoma 0 -0.423913043 0 kegg kegg NA NA no no no no no no Huntington disease Hepatocellular carcinoma 0 0.598814229 0.537194337 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Hepatocellular carcinoma 0 0.541501976 0 kegg kegg NA NA no no no no no no Influenza A Hepatocellular carcinoma 0.622608696 0 0.605148005 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Hepatocellular carcinoma 0 -0.45256917 0 kegg kegg NA NA no no no no no no Insulin resistance Hepatocellular carcinoma -0.502608696 -0.53458498 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Hepatocellular carcinoma -0.540869565 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Hepatocellular carcinoma 0 0.424901186 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Hepatocellular carcinoma 0 -0.627470356 0 kegg kegg NA NA no no no no no no Lachnospira Hepatocellular carcinoma 0 0.576723516 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Legionellosis Hepatocellular carcinoma -0.42 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Hepatocellular carcinoma 0.768695652 0.608695652 0.541827542 kegg kegg NA NA no no no no no no Long-term potentiation Hepatocellular carcinoma -0.446956522 0 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Hepatocellular carcinoma 0 -0.424901186 0 kegg kegg NA NA no no no no no no Malaria Hepatocellular carcinoma 0 0 -0.482625483 kegg kegg NA NA no no no no no no MAPK signaling pathway Hepatocellular carcinoma 0 -0.588932806 0 kegg kegg NA NA no no no no no no Melanogenesis Hepatocellular carcinoma 0 0.54743083 0 kegg kegg NA NA no no no no no no Melanoma Hepatocellular carcinoma 0 -0.514822134 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Hepatocellular carcinoma 0 0.565217391 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Hepatocellular carcinoma 0 -0.628458498 0 kegg kegg NA NA no no no no no no Mitophagy - animal Hepatocellular carcinoma 0 0 -0.444015444 kegg kegg NA NA no no no no no no Morphine addiction Hepatocellular carcinoma 0 0.482213439 0 kegg kegg NA NA no up up no no no mTOR signaling pathway Hepatocellular carcinoma -0.474782609 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Hepatocellular carcinoma 0 -0.614624506 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Hepatocellular carcinoma 0 0.495059289 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Hepatocellular carcinoma 0 -0.668972332 -0.501930502 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Hepatocellular carcinoma 0 -0.507905138 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Hepatocellular carcinoma 0 -0.663043478 -0.409009009 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Hepatocellular carcinoma 0 -0.646245059 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Hepatocellular carcinoma 0 0.540513834 0.505019305 kegg kegg NA NA no no no no no no Osteoclast differentiation Hepatocellular carcinoma 0 -0.472332016 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Hepatocellular carcinoma 0 0.617588933 0.57992278 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Hepatocellular carcinoma 0.82 0.720355731 0.474131274 kegg kegg NA NA no no no no no no p53 signaling pathway Hepatocellular carcinoma -0.648695652 -0.555335968 0 kegg kegg NA NA no no no no no no Pancreatic secretion Hepatocellular carcinoma 0 0.62055336 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Hepatocellular carcinoma 0 -0.563241107 0 kegg kegg NA NA no no dn no no no Parkinson disease Hepatocellular carcinoma 0 0.499011858 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Hepatocellular carcinoma 0 0 0.485199485 kegg kegg NA NA no no no no no no Pathways in cancer Hepatocellular carcinoma 0 -0.4743083 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Hepatocellular carcinoma 0 0.468379447 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Hepatocellular carcinoma 0 0.41798419 0 kegg kegg NA NA no no no no no no Peroxisome Hepatocellular carcinoma 0 -0.65513834 0 kegg kegg NA NA no no no no no no Phagosome Hepatocellular carcinoma 0.466086957 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Hepatocellular carcinoma 0.553043478 0.566205534 0.628056628 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Hepatocellular carcinoma -0.48173913 0 0 yes kegg kegg NA NA no up up no no no Platelet activation Hepatocellular carcinoma 0.853043478 0.878458498 0.740797941 kegg kegg NA NA no no no no no no Platinum drug resistance Hepatocellular carcinoma -0.607826087 -0.449604743 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Hepatocellular carcinoma 0 -0.524703557 0 kegg kegg NA NA no no no no no no Prion disease Hepatocellular carcinoma 0 0.599802372 0.606177606 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Hepatocellular carcinoma -0.512173913 -0.41798419 0 kegg kegg NA NA no no no no no no Prostate cancer Hepatocellular carcinoma 0 -0.429841897 0 kegg kegg NA NA no no no no no no Proteasome Hepatocellular carcinoma -0.530434783 0.41798419 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Hepatocellular carcinoma 0 -0.455533597 0 yes kegg kegg NA NA no up up no no no Protein export Hepatocellular carcinoma -0.562608696 0.491106719 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Hepatocellular carcinoma 0 0.53458498 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Hepatocellular carcinoma 0 0.424901186 0 kegg kegg NA NA no no no no no no Purine metabolism Hepatocellular carcinoma 0 0 -0.483140283 kegg kegg NA NA no no no no no no Pyrimidine metabolism Hepatocellular carcinoma 0 0.416007905 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Hepatocellular carcinoma 0.860869565 0.876482213 0.718146718 kegg kegg NA NA no no no no no no Ras signaling pathway Hepatocellular carcinoma 0 0.539525692 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Hepatocellular carcinoma 0.475652174 0.463438735 0.508365508 kegg kegg NA NA no no no no no no Renal cell carcinoma Hepatocellular carcinoma 0 0 -0.46023166 kegg kegg NA NA no no no no no no Renin secretion Hepatocellular carcinoma 0 0.589920949 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Hepatocellular carcinoma 0 0.586956522 0.488803089 kegg kegg NA NA no no up no no no Ribosome Hepatocellular carcinoma 0 0.45256917 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Hepatocellular carcinoma -0.519130435 0 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Hepatocellular carcinoma -0.515652174 -0.700592885 -0.52972973 kegg kegg NA NA no no no no no no RNA degradation Hepatocellular carcinoma 0 0.448616601 0 kegg kegg NA NA no no no no no no RNA polymerase Hepatocellular carcinoma -0.673913043 0 0 kegg kegg NA NA no no no no no no RNA transport Hepatocellular carcinoma -0.475652174 0 0 kegg kegg NA NA no no no no no no Salivary secretion Hepatocellular carcinoma 0 0.539525692 0 kegg kegg NA NA no no no no no no Salmonella infection Hepatocellular carcinoma 0 0 0.492921493 kegg kegg NA NA no no no no no no Selenocompound metabolism Hepatocellular carcinoma -0.590434783 0 0 kegg kegg NA NA no no no no no no Small cell lung cancer Hepatocellular carcinoma 0 -0.56027668 -0.519433719 kegg kegg NA NA no no up no no no SNARE interactions in vesicular transport Hepatocellular carcinoma 0 -0.628458498 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Hepatocellular carcinoma -0.704347826 0 0 kegg kegg NA NA no no no no no no Spliceosome Hepatocellular carcinoma -0.746956522 -0.471343874 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Hepatocellular carcinoma 0 -0.522727273 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Hepatocellular carcinoma 0 -0.700592885 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Hepatocellular carcinoma 0 -0.459486166 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Hepatocellular carcinoma -0.464347826 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Hepatocellular carcinoma 0 0.43083004 0 kegg kegg NA NA no no no no no no Thermogenesis Hepatocellular carcinoma 0 0.623517787 0.502445302 kegg kegg NA NA no no no no no no Thiamine metabolism Hepatocellular carcinoma 0 0 -0.498841699 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Hepatocellular carcinoma 0.96173913 0.96541502 0.947232947 kegg kegg NA NA no no no no no no Tight junction Hepatocellular carcinoma 0.734782609 0.779644269 0.535392535 kegg kegg NA NA no no no no no no TNF signaling pathway Hepatocellular carcinoma 0 -0.498023715 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Hepatocellular carcinoma 0 -0.501976285 0 yes kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Hepatocellular carcinoma -0.730434783 -0.764822134 -0.549034749 kegg kegg NA NA no no no no no no Type II diabetes mellitus Hepatocellular carcinoma 0 -0.520750988 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Hepatocellular carcinoma 0 0.416007905 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Hepatocellular carcinoma 0 0 -0.407464607 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Hepatocellular carcinoma -0.493913043 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Hepatocellular carcinoma 0 0.59486166 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Hepatocellular carcinoma 0 0.558300395 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Hepatocellular carcinoma 0.871304348 0.904150198 0.774259974 kegg kegg NA NA no no no no no no Wnt signaling pathway Hepatocellular carcinoma 0 0.541501976 0 kegg kegg NA NA no no no no no no Yersinia infection Hepatocellular carcinoma 0.514782609 0 0.64967825 kegg kegg NA NA no no no no no no 14:0/20:4-PC+blood heptanoic acid C7+blood 0 0 -0.407179487 serum_phospholipids serum_mcfa 0.486 8.27E-11 no no no dn dn no 14:1/18:2-PG+blood heptanoic acid C7+blood 0 0.544117647 0 serum_phospholipids serum_mcfa 0.00259 8.27E-11 no up up dn dn no 16:0-LPE+blood heptanoic acid C7+blood 0 0 -0.40991453 serum_phospholipids serum_mcfa 0.0711 8.27E-11 up up no dn dn no 16:0/16:1-PC+blood heptanoic acid C7+blood 0 0 -0.422905983 serum_phospholipids serum_mcfa 0.00283 8.27E-11 up up no dn dn no 16:0/20:5-PC+blood heptanoic acid C7+blood 0 -0.49754902 0 serum_phospholipids serum_mcfa 0.628 8.27E-11 no no no dn dn no 16:0/22:6-PE+blood heptanoic acid C7+blood 0 -0.522058824 0 serum_phospholipids serum_mcfa 0.000934 8.27E-11 up up no dn dn no 18:0-LPE+blood heptanoic acid C7+blood 0 0 -0.587008547 serum_phospholipids serum_mcfa 0.491 8.27E-11 no no no dn dn no 18:0/22:6-PE+blood heptanoic acid C7+blood 0 -0.553921569 0 serum_phospholipids serum_mcfa 0.00022 8.27E-11 up up no dn dn no 18:0+blood heptanoic acid C7+blood 0.448120301 0 0 serum_fattyacid serum_mcfa 0.344 8.27E-11 no no no dn dn no 18:1/20:3-PC+blood heptanoic acid C7+blood 0 0.524509804 0 serum_phospholipids serum_mcfa 0.00872 8.27E-11 no up up dn dn no 2-methyl-butyric acid m-C4+blood heptanoic acid C7+blood 0.502255639 0 0.50017094 serum_scfa serum_mcfa 0.262 8.27E-11 no no no dn dn no 20:0/20:4-PE+blood heptanoic acid C7+blood -0.448120301 0 0 serum_phospholipids serum_mcfa 0.00128 8.27E-11 up up no dn dn no 20:1-LPA+blood heptanoic acid C7+blood 0 0.512254902 0 serum_phospholipids serum_mcfa 0.0187 8.27E-11 dn dn no dn dn no 20:2-LPE+blood heptanoic acid C7+blood -0.596992481 0 0 serum_phospholipids serum_mcfa 0.177 8.27E-11 no no no dn dn no 20:2+blood heptanoic acid C7+blood 0 0.50245098 0 serum_fattyacid serum_mcfa 0.478 8.27E-11 no no no dn dn no 20:3-LPE+blood heptanoic acid C7+blood 0 0.62745098 -0.442735043 serum_phospholipids serum_mcfa 0.084 8.27E-11 no up no dn dn no 20:4-LPA+blood heptanoic acid C7+blood 0 0.544117647 0 serum_phospholipids serum_mcfa 0.398 8.27E-11 no no no dn dn no 20:5-LPC+blood heptanoic acid C7+blood 0 -0.632352941 0 serum_phospholipids serum_mcfa 0.558 8.27E-11 no no no dn dn no 20:5n3+blood heptanoic acid C7+blood 0 -0.553921569 0 serum_fattyacid serum_mcfa 0.988 8.27E-11 no no no dn dn no 22:1-LPA+blood heptanoic acid C7+blood 0 0.610294118 0 serum_phospholipids serum_mcfa 0.00373 8.27E-11 no up up dn dn no 22:2-LPA+blood heptanoic acid C7+blood 0 0.659313725 0 serum_phospholipids serum_mcfa 0.0443 8.27E-11 dn no no dn dn no 24:1+blood heptanoic acid C7+blood 0.526315789 0 0 serum_fattyacid serum_mcfa 0.00582 8.27E-11 no dn dn dn dn no acetic acid C2+blood heptanoic acid C7+blood 0.512781955 0 0 serum_scfa serum_mcfa 0.000193 8.27E-11 up dn no dn dn no butyric acid C4+blood heptanoic acid C7+blood 0.514285714 0 0 serum_scfa serum_mcfa 0.407 8.27E-11 no no no dn dn no Cysteine+blood heptanoic acid C7+blood 0 0.730392157 0 yes serum_aminoacids serum_mcfa 1.81E-07 8.27E-11 dn up up dn dn no Cystine+blood heptanoic acid C7+blood 0.464661654 0 0 yes serum_aminoacids serum_mcfa 0.00028 8.27E-11 up up no dn dn no d18:0-16:0-SM+blood heptanoic acid C7+blood -0.445112782 0 0 serum_phospholipids serum_mcfa 0.202 8.27E-11 no no no dn dn no d18:1-14:1-SM+blood heptanoic acid C7+blood 0 0 -0.465299145 serum_phospholipids serum_mcfa 0.0952 8.27E-11 no dn no dn dn no d18:1-16:0-SM+blood heptanoic acid C7+blood -0.481203008 0 0 serum_phospholipids serum_mcfa 0.14 8.27E-11 no no no dn dn no d18:1-20:0-SM+blood heptanoic acid C7+blood -0.50075188 0 0 serum_phospholipids serum_mcfa 0.933 8.27E-11 no no no dn dn no decanoic acid C10+blood heptanoic acid C7+blood 0.738345865 0.519607843 0 serum_mcfa serum_mcfa 6.64E-11 8.27E-11 dn dn no dn dn no DMG+blood heptanoic acid C7+blood 0 0 0.439316239 serum_choline serum_mcfa 0.909 8.27E-11 no no no dn dn no Antifolate resistance Herpes simplex virus 1 infection -0.545217391 -0.588932806 -0.414414414 kegg kegg NA NA no no no no no no Antigen processing and presentation Herpes simplex virus 1 infection 0.96 0.944664032 0.935649936 kegg kegg NA NA no no no no no no Axon guidance Herpes simplex virus 1 infection 0 0.454545455 0 kegg kegg NA NA no up up no no no Biosynthesis of cofactors Herpes simplex virus 1 infection 0 -0.441699605 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Herpes simplex virus 1 infection 0.423478261 0.520750988 0.66975547 kegg kegg NA NA no no no no no no Cellular senescence Herpes simplex virus 1 infection 0.536521739 0.445652174 0.590990991 kegg kegg NA NA no no no no no no Cholesterol metabolism Herpes simplex virus 1 infection 0.44 0.502964427 0 yes kegg kegg NA NA no no up no no no Cocaine addiction Herpes simplex virus 1 infection 0 -0.495059289 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Herpes simplex virus 1 infection -0.464347826 -0.567193676 0 kegg kegg NA NA no no up no no no Cushing syndrome Herpes simplex virus 1 infection -0.52173913 -0.503952569 0 kegg kegg NA NA no no up no no no Desulfovibrio Herpes simplex virus 1 infection 0 0.422326513 0 Genus kegg 0.27 NA no no no no no no Drug metabolism - cytochrome P450 Herpes simplex virus 1 infection 0.433043478 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Herpes simplex virus 1 infection -0.586086957 -0.673913043 -0.431145431 kegg kegg NA NA no no no no no no Endocytosis Herpes simplex virus 1 infection 0.486086957 0.511857708 0.60952381 kegg kegg NA NA no no no no no no Ether lipid metabolism Herpes simplex virus 1 infection -0.486086957 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Herpes simplex virus 1 infection 0 -0.502964427 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Herpes simplex virus 1 infection 0 -0.57312253 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Herpes simplex virus 1 infection -0.410434783 -0.491106719 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Herpes simplex virus 1 infection -0.676521739 -0.56027668 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Herpes simplex virus 1 infection 0 -0.488142292 0 kegg kegg NA NA no up no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Herpes simplex virus 1 infection 0 -0.516798419 0 kegg kegg NA NA no no no no no no GnRH secretion Herpes simplex virus 1 infection 0 0 -0.42007722 kegg kegg NA NA no up up no no no GnRH signaling pathway Herpes simplex virus 1 infection 0 -0.438735178 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Herpes simplex virus 1 infection -0.443478261 -0.542490119 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Herpes simplex virus 1 infection -0.569565217 -0.511857708 0 kegg kegg NA NA no no no no no no Homologous recombination Herpes simplex virus 1 infection 0 -0.418972332 0 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Herpes simplex virus 1 infection 0.940869565 0.945652174 0.882882883 kegg kegg NA NA no no dn no no no Human papillomavirus infection Herpes simplex virus 1 infection 0.466956522 0 0.509395109 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection 0.973043478 0.97826087 0.968854569 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Herpes simplex virus 1 infection -0.506956522 -0.449604743 -0.506563707 kegg kegg NA NA no no no no no no Insulin secretion Herpes simplex virus 1 infection -0.496521739 -0.437747036 0 yes kegg kegg NA NA no up up no no no Lachnospira Herpes simplex virus 1 infection -0.417391304 0 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Leishmaniasis Herpes simplex virus 1 infection 0.454782609 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Herpes simplex virus 1 infection 0 0.420948617 0 kegg kegg NA NA no no no no no no Lysine degradation Herpes simplex virus 1 infection 0 -0.493083004 0 kegg kegg NA NA no no no no no no Lysosome Herpes simplex virus 1 infection 0 0.454545455 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Herpes simplex virus 1 infection 0 -0.415019763 0 kegg kegg NA NA no up no no no no Natural killer cell mediated cytotoxicity Herpes simplex virus 1 infection 0.569565217 0.510869565 0.655083655 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Herpes simplex virus 1 infection 0 0.509881423 0 kegg kegg NA NA up up up no no no Nicotine addiction Herpes simplex virus 1 infection 0 -0.536561265 0 kegg kegg NA NA no up up no no no Notch signaling pathway Herpes simplex virus 1 infection 0 -0.498023715 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Herpes simplex virus 1 infection 0 -0.526679842 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Herpes simplex virus 1 infection -0.495652174 -0.435770751 0 kegg kegg NA NA no up up no no no Phagosome Herpes simplex virus 1 infection 0 0.48715415 0.553410553 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Herpes simplex virus 1 infection 0 0 -0.4002574 kegg kegg NA NA no up up no no no Phototransduction Herpes simplex virus 1 infection 0 0.455533597 0 kegg kegg NA NA no no no no no no Platinum drug resistance Herpes simplex virus 1 infection 0 -0.445652174 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Herpes simplex virus 1 infection 0 -0.416996047 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Herpes simplex virus 1 infection 0.493043478 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Herpes simplex virus 1 infection 0 -0.438735178 0 kegg kegg NA NA no no no no no no Proteasome Herpes simplex virus 1 infection 0.416521739 0 0.493693694 kegg kegg NA NA no no no no no no Protein digestion and absorption Herpes simplex virus 1 infection 0 0 -0.423938224 yes kegg kegg NA NA no up up no no no Purine metabolism Herpes simplex virus 1 infection 0 -0.501976285 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Herpes simplex virus 1 infection 0.423478261 0 0.458429858 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Herpes simplex virus 1 infection 0 -0.469367589 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Herpes simplex virus 1 infection 0 0.468379447 0 kegg kegg NA NA no no no no no no Salmonella infection Herpes simplex virus 1 infection 0.451304348 0.470355731 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Herpes simplex virus 1 infection 0 -0.542490119 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Herpes simplex virus 1 infection 0 0 -0.419047619 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Herpes simplex virus 1 infection 0 0.494071146 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Herpes simplex virus 1 infection 0 0.472332016 0 kegg kegg NA NA up no no no no no Taste transduction Herpes simplex virus 1 infection 0 0 -0.416216216 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Herpes simplex virus 1 infection 0 -0.522727273 0 kegg kegg NA NA no no no no no no Tuberculosis Herpes simplex virus 1 infection 0 0.424901186 0 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Herpes simplex virus 1 infection 0 0.526679842 0.694465894 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Herpes simplex virus 1 infection -0.493043478 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Herpes simplex virus 1 infection 0 0 0.406177606 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Herpes simplex virus 1 infection -0.5 0 0 kegg kegg NA NA no no no no no no ABC transporters HIF-1 signaling pathway 0 -0.577075099 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" HIF-1 signaling pathway 0 -0.555335968 0 kegg kegg NA NA no no no no no no Alistipes HIF-1 signaling pathway 0 0 -0.423196228 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism HIF-1 signaling pathway 0 -0.738142292 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism HIF-1 signaling pathway 0 -0.586956522 0 kegg kegg NA NA no up no no no no Arginine biosynthesis HIF-1 signaling pathway 0 -0.509881423 0 kegg kegg NA NA no no no no no no Basal transcription factors HIF-1 signaling pathway 0.573913043 0 0 kegg kegg NA NA no no no no no no Base excision repair HIF-1 signaling pathway 0.572173913 0 0 kegg kegg NA NA no no no no no no Bifidobacterium HIF-1 signaling pathway 0 0.421497083 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Butanoate metabolism HIF-1 signaling pathway 0 0.558300395 0.574002574 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) HIF-1 signaling pathway 0 0.575098814 0.514285714 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism HIF-1 signaling pathway 0.41826087 0.773715415 0.597940798 kegg kegg NA NA no no no no no no DNA replication HIF-1 signaling pathway 0.500869565 0.494071146 0.515830116 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 HIF-1 signaling pathway 0 0.589920949 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes HIF-1 signaling pathway 0 0.615612648 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance HIF-1 signaling pathway 0.908695652 0.954545455 0.951351351 kegg kegg NA NA no no no no no no Endocrine resistance HIF-1 signaling pathway 0 0 -0.409266409 kegg kegg NA NA no no no no no no Fatty acid biosynthesis HIF-1 signaling pathway 0 -0.562252964 0 kegg kegg NA NA no no no no no no Fatty acid degradation HIF-1 signaling pathway 0 -0.435770751 0 kegg kegg NA NA no no no no no no Fatty acid elongation HIF-1 signaling pathway 0 0.453557312 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism HIF-1 signaling pathway 0 -0.628458498 0 kegg kegg NA NA no no no no no no Galactose metabolism HIF-1 signaling pathway 0 -0.597826087 0 kegg kegg NA NA no no no no no no Glutathione metabolism HIF-1 signaling pathway 0 0.633399209 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism HIF-1 signaling pathway 0 -0.650197628 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism HIF-1 signaling pathway 0 -0.621541502 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis HIF-1 signaling pathway 0 0.793478261 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate HIF-1 signaling pathway 0 -0.736166008 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation HIF-1 signaling pathway -0.416521739 -0.468379447 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series HIF-1 signaling pathway 0 -0.479249012 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism HIF-1 signaling pathway 0 -0.459486166 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism HIF-1 signaling pathway 0 -0.455533597 0 kegg kegg NA NA no no no no no no Lysine degradation HIF-1 signaling pathway 0.636521739 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 HIF-1 signaling pathway 0 0.551383399 0 kegg kegg NA NA no no no no no no Mismatch repair HIF-1 signaling pathway 0 0.440711462 0.428056628 kegg kegg NA NA no no no no no no mRNA surveillance pathway HIF-1 signaling pathway 0 0.422924901 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis HIF-1 signaling pathway 0 0.518774704 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway HIF-1 signaling pathway 0 -0.695652174 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism HIF-1 signaling pathway 0 -0.613636364 0 kegg kegg NA NA no no no no no no Nitrogen metabolism HIF-1 signaling pathway 0 -0.467391304 0 kegg kegg NA NA no no no no no no Non-homologous end-joining HIF-1 signaling pathway 0 0.548418972 0.447361647 kegg kegg NA NA no no no no no no Nucleotide excision repair HIF-1 signaling pathway 0.432173913 0 0.423938224 kegg kegg NA NA no no no no no no Other glycan degradation HIF-1 signaling pathway 0 -0.584980237 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation HIF-1 signaling pathway 0 0.639328063 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis HIF-1 signaling pathway 0 -0.624505929 0 kegg kegg NA NA no no dn no no no Parabacteroides HIF-1 signaling pathway 0 0 -0.445202395 Genus kegg 4.19E-05 NA no up up no no no Pentose and glucuronate interconversions HIF-1 signaling pathway 0 0.52173913 0 kegg kegg NA NA no no no no no no Propanoate metabolism HIF-1 signaling pathway 0 0.81027668 0.706821107 kegg kegg NA NA no no no no no no Proteasome HIF-1 signaling pathway 0.512173913 0.624505929 0.562419562 kegg kegg NA NA no no no no no no Protein export HIF-1 signaling pathway 0.51826087 0.726284585 0.508622909 kegg kegg NA NA no no no no no no Pyruvate metabolism HIF-1 signaling pathway 0 0.805335968 0.575032175 kegg kegg NA NA no no no no no no Rap1 signaling pathway HIF-1 signaling pathway -0.591304348 0 0 kegg kegg NA NA no no no no no no Ras signaling pathway HIF-1 signaling pathway 0 0.416996047 0 yes kegg kegg NA NA no up up no no no Ribosome HIF-1 signaling pathway 0.555652174 0.87944664 0.793050193 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes HIF-1 signaling pathway 0.651304348 0 0 kegg kegg NA NA no no no no no no RNA degradation HIF-1 signaling pathway 0 0.588932806 0.421364221 kegg kegg NA NA no no no no no no RNA polymerase HIF-1 signaling pathway 0.594782609 0.441699605 0.471557272 kegg kegg NA NA no no no no no no RNA transport HIF-1 signaling pathway 0.626086957 0.933794466 0.734105534 kegg kegg NA NA no no no no no no Selenocompound metabolism HIF-1 signaling pathway 0.492173913 0 0 kegg kegg NA NA no no no no no no Spliceosome HIF-1 signaling pathway 0.684347826 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism HIF-1 signaling pathway 0 -0.662055336 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism HIF-1 signaling pathway 0 -0.592885375 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis HIF-1 signaling pathway 0.406086957 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism HIF-1 signaling pathway 0 0.686758893 0 kegg kegg NA NA no no no no no no Tryptophan metabolism HIF-1 signaling pathway 0 0.414031621 0.513256113 kegg kegg NA NA no up no no no no Tyrosine metabolism HIF-1 signaling pathway 0 0.42687747 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" HIF-1 signaling pathway 0 0 0.461776062 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis HIF-1 signaling pathway 0.567826087 0.416007905 0 kegg kegg NA NA no no no no no no 12-ketoDCA+stool hipline+clinic 0 0 -0.424054207 stool_bileacids clinic 0.505 8.08E-05 no no no up up no 15-HETE+blood hipline+clinic 0 0 0.498894461 serum_ARA clinic 0.819 8.08E-05 no no no up up no 16:0/16:0-PC+blood hipline+clinic 0.562435501 0 0 serum_phospholipids clinic 0.00079 8.08E-05 no up up up up no 16:0/18:2-PI+blood hipline+clinic 0 -0.603571429 0 serum_phospholipids clinic 0.269 8.08E-05 no no no up up no 16:1/16:0-PC+blood hipline+clinic 0 0 0.414615385 serum_phospholipids clinic 0.0215 8.08E-05 no up up up up no 18:0-LPC+blood hipline+clinic 0 -0.564285714 0 serum_phospholipids clinic 0.554 8.08E-05 no no no up up no 18:0/18:1-PE+blood hipline+clinic 0 0 -0.501538462 serum_phospholipids clinic 0.00716 8.08E-05 up up no up up no 18:0/20:3-PC+blood hipline+clinic 0 0 -0.472307692 serum_phospholipids clinic 0.0682 8.08E-05 no up no up up no 18:0/20:3-PI+blood hipline+clinic 0 0 -0.429230769 serum_phospholipids clinic 0.377 8.08E-05 no no no up up no 18:0/20:5-PC+blood hipline+clinic 0 0 0.453076923 serum_phospholipids clinic 0.17 8.08E-05 no no no up up no 18:1/18:1-PE+blood hipline+clinic 0 -0.567857143 0 serum_phospholipids clinic 1.03E-05 8.08E-05 up up no up up no 18:2/16:0-PC+blood hipline+clinic 0.475748194 0 0 serum_phospholipids clinic 8.67E-05 8.08E-05 no up up up up no 20:1-LPA+blood hipline+clinic 0.560371517 0 0 serum_phospholipids clinic 0.0187 8.08E-05 dn dn no up up no 20:2/18:0-PC+blood hipline+clinic 0 0 -0.486923077 serum_phospholipids clinic 0.0427 8.08E-05 no up no up up no 20:3/18:0-PC+blood hipline+clinic 0 0 0.437692308 serum_phospholipids clinic 0.296 8.08E-05 no no no up up no 20:3n6+blood hipline+clinic -0.636738906 0 -0.499230769 serum_fattyacid clinic 0.0884 8.08E-05 up no no up up no 24:1+blood hipline+clinic 0 0 0.477692308 serum_fattyacid clinic 0.00582 8.08E-05 no dn dn up up no 4-hydroxybenzoic acid+urine hipline+clinic 0 0 0.407692308 urine_cometabolism clinic 0.52 8.08E-05 no no no up up no AA+blood hipline+clinic 0 0.610714286 0 serum_ARA clinic 0.212 8.08E-05 no no no up up no Akkermansia hipline+clinic 0 0 -0.405127354 acetate-producing Genus clinic 0.23 8.08E-05 no no no up up no Bacteroides hipline+clinic 0 0.487295313 0 LPS-producing Genus clinic 0.000267 8.08E-05 dn dn up up up no Blautia hipline+clinic -0.445652174 0 0 acetate-producing Genus clinic 1.36E-05 8.08E-05 up dn dn up up no C-peptide hipline+clinic 0 -0.511010728 0 DM-assocaited hormones clinic 0.228 8.08E-05 no no no up up no Cystine+blood hipline+clinic 0 0 0.421538462 yes serum_aminoacids clinic 0.00028 8.08E-05 up up no up up no d18:1-18:0-SM+blood hipline+clinic 0 0 0.442307692 serum_phospholipids clinic 0.97 8.08E-05 no no no up up no Endocrine resistance hipline+clinic 0 -0.437662338 0 kegg clinic NA 8.08E-05 no no no up up no FGF basic hipline+clinic 0.565934066 0 0 serum_cytokines clinic 0.65 8.08E-05 no no no up up no Glycine+blood hipline+clinic 0 0 0.528461538 serum_aminoacids clinic 0.00408 8.08E-05 dn no up up up no L-2-Aminobutyric acid+blood hipline+clinic 0 0.546428571 0 yes serum_aminoacids clinic 0.000328 8.08E-05 up up no up up no L-Glutamine+blood hipline+clinic 0 0 0.419230769 serum_aminoacids clinic 0.639 8.08E-05 no no no up up no L-Proline+blood hipline+clinic 0 -0.671428571 0 yes serum_aminoacids clinic 0.00265 8.08E-05 up up no up up no Legionellosis hipline+clinic 0 0.48961039 0 kegg clinic NA 8.08E-05 no no no up up no Measles hipline+clinic 0 0.657142857 0 kegg clinic NA 8.08E-05 no no no up up no Methanobrevibacter hipline+clinic 0 0.427723611 0 Genus clinic 0.629 8.08E-05 no no no up up no Morphine addiction hipline+clinic 0 -0.437662338 0 kegg clinic NA 8.08E-05 no up up up up no Oscillospira hipline+clinic 0 0.470355731 0 LPS-producing Genus clinic 0.62 8.08E-05 no no no up up no Parabacteroides hipline+clinic 0 0.465838509 0 Genus clinic 4.19E-05 8.08E-05 no up up up up no Paraprevotella hipline+clinic 0 -0.521068879 0 Genus clinic 0.118 8.08E-05 no no no up up no PI3K-Akt signaling pathway hipline+clinic 0.460191982 0.518181818 0 yes kegg clinic NA 8.08E-05 no up up up up no Primary immunodeficiency hipline+clinic 0.483907397 0 0 kegg clinic NA 8.08E-05 no no no up up no Rap1 signaling pathway hipline+clinic 0 -0.448051948 0 kegg clinic NA 8.08E-05 no no no up up no Regulation of lipolysis in adipocytes hipline+clinic 0 -0.435064935 0 kegg clinic NA 8.08E-05 no no no up up no Roseburia hipline+clinic 0 -0.471053394 0 butyrate-producing Genus clinic 0.495 8.08E-05 no no no up up no Toxoplasmosis hipline+clinic 0 0.444155844 0 kegg clinic NA 8.08E-05 no no no up up no Viral myocarditis hipline+clinic -0.438735178 0 0 kegg clinic NA 8.08E-05 no no no up up no Visfatin hipline+clinic 0 0 0.497326203 DM-assocaited hormones clinic 0.0229 8.08E-05 dn no up up up no 2-Oxocarboxylic acid metabolism Hippo signaling pathway 0.406086957 0.652173913 0 kegg kegg NA NA no no no no no no ABC transporters Hippo signaling pathway 0 -0.522727273 0 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes Hippo signaling pathway 0 0.4743083 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Hippo signaling pathway -0.568695652 -0.826086957 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Hippo signaling pathway 0 -0.523715415 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Hippo signaling pathway 0 0.536561265 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Hippo signaling pathway -0.56173913 -0.482213439 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Hippo signaling pathway 0 -0.713438735 -0.551866152 kegg kegg NA NA no up no no no no Arginine biosynthesis Hippo signaling pathway -0.482608696 -0.773715415 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Hippo signaling pathway 0 0.504940711 0 kegg kegg NA NA no no no no no no Autophagy - animal Hippo signaling pathway -0.808695652 -0.885375494 -0.41981982 kegg kegg NA NA no no no no no no Autophagy - other Hippo signaling pathway -0.753913043 -0.615612648 0 kegg kegg NA NA no no no no no no Basal transcription factors Hippo signaling pathway -0.50173913 0 0 kegg kegg NA NA no no no no no no Base excision repair Hippo signaling pathway -0.454782609 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Hippo signaling pathway 0 0.419960474 0 kegg kegg NA NA no no no no no no Bifidobacterium Hippo signaling pathway 0 0.507183328 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Biosynthesis of unsaturated fatty acids Hippo signaling pathway 0 0 0.404890605 kegg kegg NA NA no no no no no no Butanoate metabolism Hippo signaling pathway 0 0.58201581 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Hippo signaling pathway 0 0.453557312 0 kegg kegg NA NA no up up no no no Cardiac muscle contraction Hippo signaling pathway 0 0.670948617 0.623423423 kegg kegg NA NA no no up no no no cGMP-PKG signaling pathway Hippo signaling pathway 0 -0.444664032 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Hippo signaling pathway 0 0.575098814 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Hippo signaling pathway 0 0.5 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Hippo signaling pathway 0 0 0.594594595 kegg kegg NA NA no no no no no no DNA replication Hippo signaling pathway 0 0.515810277 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Hippo signaling pathway 0 0.697628458 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Hippo signaling pathway 0 0.814229249 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Hippo signaling pathway 0 0.425889328 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Hippo signaling pathway 0 -0.484189723 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Hippo signaling pathway -0.526956522 -0.741106719 -0.472329472 kegg kegg NA NA no no no no no no Fatty acid degradation Hippo signaling pathway 0 -0.635375494 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Hippo signaling pathway 0 -0.587944664 0 kegg kegg NA NA no no no no no no Folate biosynthesis Hippo signaling pathway 0 0.616600791 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Hippo signaling pathway -0.506956522 -0.697628458 0 kegg kegg NA NA no no no no no no Galactose metabolism Hippo signaling pathway 0 -0.427865613 0 kegg kegg NA NA no no no no no no Glutathione metabolism Hippo signaling pathway 0 0.442687747 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Hippo signaling pathway 0 -0.563241107 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Hippo signaling pathway 0 -0.612648221 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Hippo signaling pathway 0 0.615612648 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Hippo signaling pathway 0 -0.693675889 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Hippo signaling pathway 0.651304348 0.524703557 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Hippo signaling pathway -0.44173913 -0.767786561 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Hippo signaling pathway -0.449565217 0.501976285 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Hippo signaling pathway 0 -0.477272727 0 kegg kegg NA NA no no no no no no Lachnospira Hippo signaling pathway 0 0.553496434 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Longevity regulating pathway Hippo signaling pathway 0 -0.482213439 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Hippo signaling pathway 0 -0.563241107 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Hippo signaling pathway 0 0.727272727 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Hippo signaling pathway 0 -0.486166008 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Hippo signaling pathway 0 0.666007905 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Hippo signaling pathway -0.488695652 -0.776679842 -0.638610039 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Hippo signaling pathway -0.452173913 -0.664031621 -0.407722008 kegg kegg NA NA no no no no no no Nitrogen metabolism Hippo signaling pathway 0 -0.792490119 -0.430888031 kegg kegg NA NA no no no no no no Notch signaling pathway Hippo signaling pathway 0 -0.416007905 0 kegg kegg NA NA no no no no no no One carbon pool by folate Hippo signaling pathway 0 0.466403162 0 kegg kegg NA NA no no no no no no Oocyte meiosis Hippo signaling pathway 0 0.51284585 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Hippo signaling pathway 0 -0.56027668 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Hippo signaling pathway 0 0.662055336 0.595624196 kegg kegg NA NA no no no no no no p53 signaling pathway Hippo signaling pathway -0.648695652 -0.542490119 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Hippo signaling pathway 0 -0.619565217 0 kegg kegg NA NA no no dn no no no Paraprevotella Hippo signaling pathway 0 0.446186177 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Hippo signaling pathway 0.443478261 0.637351779 0 kegg kegg NA NA no no no no no no Peroxisome Hippo signaling pathway -0.459130435 -0.67687747 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Hippo signaling pathway 0.734782609 0.688735178 0.558558559 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Hippo signaling pathway 0 -0.571146245 0 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Hippo signaling pathway -0.411304348 0 0 yes kegg kegg NA NA no up up no no no Platinum drug resistance Hippo signaling pathway -0.593043478 -0.416996047 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Hippo signaling pathway -0.431304348 -0.64229249 0 kegg kegg NA NA no no no no no no Prevotella Hippo signaling pathway 0 -0.449293214 0 acetate-producing Genus kegg 0.287 NA no no no no no no Propanoate metabolism Hippo signaling pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Proteasome Hippo signaling pathway -0.483478261 0.632411067 0 kegg kegg NA NA no no no no no no Protein export Hippo signaling pathway 0 0.687747036 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Hippo signaling pathway 0 0.517786561 0 kegg kegg NA NA no no no no no no Purine metabolism Hippo signaling pathway 0 0 -0.522522523 kegg kegg NA NA no no no no no no Pyrimidine metabolism Hippo signaling pathway 0 0.54743083 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Hippo signaling pathway 0 0.513833992 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Hippo signaling pathway 0.750434783 0.755928854 0.741312741 kegg kegg NA NA no no no no no no Ras signaling pathway Hippo signaling pathway 0 0.679841897 0 yes kegg kegg NA NA no up up no no no Ribosome Hippo signaling pathway 0 0.52173913 0 kegg kegg NA NA no no no no no no RNA degradation Hippo signaling pathway 0 0.583003953 0 kegg kegg NA NA no no no no no no RNA polymerase Hippo signaling pathway -0.459130435 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Hippo signaling pathway -0.57826087 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Hippo signaling pathway 0 -0.609683794 0 kegg kegg NA NA no no no no no no Spliceosome Hippo signaling pathway -0.630434783 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Hippo signaling pathway 0 -0.657114625 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Hippo signaling pathway 0 -0.613636364 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Hippo signaling pathway 0 0.638339921 0 kegg kegg NA NA no no no no no no Thiamine metabolism Hippo signaling pathway 0 0 -0.563191763 kegg kegg NA NA no no no no no no Tryptophan metabolism Hippo signaling pathway 0 0.500988142 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Hippo signaling pathway 0.409565217 0.538537549 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Hippo signaling pathway 0 0.501976285 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Hippo signaling pathway 0 0.501976285 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Hippo signaling pathway 0 0.656126482 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Hippo signaling pathway 0 0.660079051 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Hippo signaling pathway - multiple species 0 -0.628458498 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Hippo signaling pathway - multiple species 0 0.641304348 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Hippo signaling pathway - multiple species 0 0.658102767 0.594079794 kegg kegg NA NA no no no no no no AMPK signaling pathway Hippo signaling pathway - multiple species -0.673043478 -0.51284585 -0.693178893 kegg kegg NA NA no no no no no no Apelin signaling pathway Hippo signaling pathway - multiple species 0 -0.780632411 0 kegg kegg NA NA no no no no no no Apoptosis Hippo signaling pathway - multiple species 0 0.639328063 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Hippo signaling pathway - multiple species 0.432173913 0.805335968 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Hippo signaling pathway - multiple species 0 0.56027668 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Hippo signaling pathway - multiple species 0 0 0.497039897 kegg kegg NA NA no no no no no no Autophagy - animal Hippo signaling pathway - multiple species 0 0.670948617 0.476962677 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Hippo signaling pathway - multiple species -0.633043478 0 -0.528185328 kegg kegg NA NA no no no no no no Butanoate metabolism Hippo signaling pathway - multiple species 0 -0.48715415 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Hippo signaling pathway - multiple species 0 -0.574110672 0 kegg kegg NA NA no up up no no no Cardiac muscle contraction Hippo signaling pathway - multiple species 0 -0.760869565 0 kegg kegg NA NA no no up no no no Cell cycle Hippo signaling pathway - multiple species 0 -0.462450593 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Hippo signaling pathway - multiple species 0.584347826 0.598814229 0.503989704 kegg kegg NA NA no no no no no no Chemokine signaling pathway Hippo signaling pathway - multiple species 0 0.440711462 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Hippo signaling pathway - multiple species 0 -0.447628458 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Hippo signaling pathway - multiple species 0 -0.581027668 0 kegg kegg NA NA no no no no no no DNA replication Hippo signaling pathway - multiple species 0 -0.523715415 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Hippo signaling pathway - multiple species 0 -0.519762846 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Hippo signaling pathway - multiple species 0 -0.516798419 0.46023166 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Hippo signaling pathway - multiple species 0 -0.758893281 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Hippo signaling pathway - multiple species 0 0 0.47953668 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Hippo signaling pathway - multiple species 0 0.600790514 0 kegg kegg NA NA no no no no no no Fatty acid degradation Hippo signaling pathway - multiple species 0 0.467391304 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Hippo signaling pathway - multiple species 0 0.48715415 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Hippo signaling pathway - multiple species 0 0.522727273 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Hippo signaling pathway - multiple species 0 0.444664032 0.476447876 kegg kegg NA NA no no no no no no Galactose metabolism Hippo signaling pathway - multiple species 0 0.523715415 0.567310167 kegg kegg NA NA no no no no no no Glutathione metabolism Hippo signaling pathway - multiple species -0.503478261 -0.592885375 -0.562419562 kegg kegg NA NA no no no no no no Glycerolipid metabolism Hippo signaling pathway - multiple species 0 0.428853755 0.540540541 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Hippo signaling pathway - multiple species 0 0 0.483397683 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Hippo signaling pathway - multiple species -0.693043478 -0.470355731 -0.524581725 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Hippo signaling pathway - multiple species 0 -0.556324111 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Hippo signaling pathway - multiple species 0 0.583003953 0.713770914 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Hippo signaling pathway - multiple species 0 0 0.603861004 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Hippo signaling pathway - multiple species 0.431304348 0.601778656 0.794594595 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Hippo signaling pathway - multiple species 0 0.568181818 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Hippo signaling pathway - multiple species 0 -0.756916996 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Hippo signaling pathway - multiple species 0 -0.577075099 0 kegg kegg NA NA no no no no no no Histidine metabolism Hippo signaling pathway - multiple species 0 0.51284585 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Hippo signaling pathway - multiple species 0 0 0.475160875 kegg kegg NA NA no no no no no no Longevity regulating pathway Hippo signaling pathway - multiple species 0 0 -0.613899614 kegg kegg NA NA no no no no no no Lysine degradation Hippo signaling pathway - multiple species 0 0 0.422136422 kegg kegg NA NA no no no no no no Lysosome Hippo signaling pathway - multiple species 0.512173913 0 0.516087516 kegg kegg NA NA no no no no no no MAPK signaling pathway Hippo signaling pathway - multiple species 0 0.425889328 0.44993565 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Hippo signaling pathway - multiple species 0 -0.453557312 0 kegg kegg NA NA no no no no no no Mitophagy - animal Hippo signaling pathway - multiple species 0 -0.604743083 -0.629343629 kegg kegg NA NA no no no no no no mRNA surveillance pathway Hippo signaling pathway - multiple species 0 -0.483201581 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Hippo signaling pathway - multiple species 0 -0.719367589 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Hippo signaling pathway - multiple species 0 -0.592885375 0 kegg kegg NA NA no no no no no no Necroptosis Hippo signaling pathway - multiple species 0 0 -0.464092664 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Hippo signaling pathway - multiple species 0 0.429841897 0 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Hippo signaling pathway - multiple species 0.526086957 0.719367589 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Hippo signaling pathway - multiple species 0.409565217 0.670948617 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Hippo signaling pathway - multiple species 0 0.545454545 0 kegg kegg NA NA no no no no no no Notch signaling pathway Hippo signaling pathway - multiple species 0.471304348 0 0.638352638 kegg kegg NA NA no no no no no no Oocyte meiosis Hippo signaling pathway - multiple species 0 -0.454545455 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Hippo signaling pathway - multiple species 0.646956522 0.647233202 0 kegg kegg NA NA no no no no no no Other glycan degradation Hippo signaling pathway - multiple species 0 0.545454545 0.685971686 kegg kegg NA NA no no no no no no Oxidative phosphorylation Hippo signaling pathway - multiple species 0 -0.730237154 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Hippo signaling pathway - multiple species 0.547826087 0.770750988 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Hippo signaling pathway - multiple species 0 -0.451581028 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Hippo signaling pathway - multiple species 0 0.414031621 0 kegg kegg NA NA no no no no no no Peroxisome Hippo signaling pathway - multiple species 0 0.563241107 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Hippo signaling pathway - multiple species 0 0.574110672 0 kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism Hippo signaling pathway - multiple species -0.726086957 0 -0.551608752 kegg kegg NA NA no no no no no no PPAR signaling pathway Hippo signaling pathway - multiple species 0.433043478 0.43972332 0 kegg kegg NA NA no no no no no no Propanoate metabolism Hippo signaling pathway - multiple species 0 -0.58201581 0 kegg kegg NA NA no no no no no no Proteasome Hippo signaling pathway - multiple species 0 -0.472332016 0 kegg kegg NA NA no no no no no no Protein export Hippo signaling pathway - multiple species 0 -0.580039526 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Hippo signaling pathway - multiple species -0.406956522 -0.548418972 -0.587644788 kegg kegg NA NA no no no no no no Purine metabolism Hippo signaling pathway - multiple species -0.632173913 -0.420948617 -0.458687259 kegg kegg NA NA no no no no no no Pyruvate metabolism Hippo signaling pathway - multiple species 0 -0.648221344 -0.471814672 kegg kegg NA NA no no no no no no Ras signaling pathway Hippo signaling pathway - multiple species 0 -0.448616601 0 yes kegg kegg NA NA no up up no no no Ribosome Hippo signaling pathway - multiple species 0 -0.798418972 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Hippo signaling pathway - multiple species 0 -0.41798419 0 kegg kegg NA NA no no no no no no RNA degradation Hippo signaling pathway - multiple species 0 -0.549407115 0 kegg kegg NA NA no no no no no no RNA polymerase Hippo signaling pathway - multiple species 0 -0.522727273 0 kegg kegg NA NA no no no no no no RNA transport Hippo signaling pathway - multiple species 0 -0.684782609 -0.407464607 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Hippo signaling pathway - multiple species 0.422608696 0.72826087 0.493178893 kegg kegg NA NA no no no no no no Sphingolipid metabolism Hippo signaling pathway - multiple species 0 0 0.742857143 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Hippo signaling pathway - multiple species 0 0 0.573745174 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Hippo signaling pathway - multiple species 0 0.708498024 0.575804376 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Hippo signaling pathway - multiple species 0 -0.489130435 0 kegg kegg NA NA no no no no no no Thiamine metabolism Hippo signaling pathway - multiple species 0 -0.502964427 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Hippo signaling pathway - multiple species 0 -0.619565217 -0.64015444 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Hippo signaling pathway - multiple species 0 -0.489130435 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Hippo signaling pathway - multiple species 0 -0.597826087 -0.446589447 kegg kegg NA NA no no no no no no VEGF signaling pathway Hippo signaling pathway - multiple species 0 0 0.56010296 kegg kegg NA NA no no no no no no Wnt signaling pathway Hippo signaling pathway - multiple species 0 -0.603754941 0 kegg kegg NA NA no no no no no no 12-ketoDCA+stool Hippuric acid+urine 0 0.711303297 0 stool_bileacids urine_cometabolism 0.505 0.361 no no no no no no 13-HODE+blood Hippuric acid+urine 0 0 0.588311688 serum_ARA urine_cometabolism 0.32 0.361 no no no no no no 16:0/18:2-PC+blood Hippuric acid+urine 0 0 0.485714286 serum_phospholipids urine_cometabolism 3.24E-06 0.361 no up up no no no 16:0/22:6-PC+blood Hippuric acid+urine 0 0 0.448051948 serum_phospholipids urine_cometabolism 4.53E-05 0.361 no up up no no no 18:0/18:2-PC+blood Hippuric acid+urine 0 0 0.464935065 serum_phospholipids urine_cometabolism 1.74E-06 0.361 no up up no no no 18:0/22:6-PC+blood Hippuric acid+urine 0 0 0.492207792 serum_phospholipids urine_cometabolism 0.0775 0.361 no no up no no no 18:0+blood Hippuric acid+urine 0 0 0.557142857 serum_fattyacid urine_cometabolism 0.344 0.361 no no no no no no 18:1/16:0-PC+blood Hippuric acid+urine 0 0 0.471428571 serum_phospholipids urine_cometabolism 2.43E-05 0.361 no up up no no no 18:1/18:0-PC+blood Hippuric acid+urine 0 0 0.448051948 serum_phospholipids urine_cometabolism 1.83E-06 0.361 no up up no no no 18:2/20:4-PC+blood Hippuric acid+urine 0 0.576923077 0 serum_phospholipids urine_cometabolism 0.0145 0.361 no no up no no no 18:3n6+blood Hippuric acid+urine 0 0.565934066 0 serum_fattyacid urine_cometabolism 0.0463 0.361 up no dn no no no 2-hydroxyphenylacetic acid+urine Hippuric acid+urine 0 0 -0.401025641 urine_cometabolism urine_cometabolism 0.763 0.361 no no no no no no 20:1+blood Hippuric acid+urine -0.517156863 0 0 yes serum_fattyacid urine_cometabolism 2.56E-05 0.361 dn dn dn no no no 20:5/18:0-PC+blood Hippuric acid+urine 0 0 0.468831169 serum_phospholipids urine_cometabolism 3.97E-06 0.361 no up up no no no 3-Hydroxytyramine hydrochloride+urine Hippuric acid+urine 0 -0.564912281 0 urine_cometabolism urine_cometabolism 0.288 0.361 no no no no no no 5-Hydroxyindole-3-acetic Acid+urine Hippuric acid+urine -0.627067669 0 0 urine_cometabolism urine_cometabolism 0.0405 0.361 no dn dn no no no 5-Hydroxytryptamine+urine Hippuric acid+urine -0.469172932 -0.6 0 urine_cometabolism urine_cometabolism 0.171 0.361 no no no no no no 8-HETE+blood Hippuric acid+urine 0 0 0.632467532 serum_ARA urine_cometabolism 0.741 0.361 no no no no no no Adherens junction Hippuric acid+urine 0 -0.566666667 -0.476923077 kegg urine_cometabolism NA 0.361 no no no no no no Adrenergic signaling in cardiomyocytes Hippuric acid+urine 0 0 -0.626923077 kegg urine_cometabolism NA 0.361 no no up no no no AGE-RAGE signaling pathway in diabetic complications Hippuric acid+urine 0 0 0.436923077 kegg urine_cometabolism NA 0.361 no no no no no no Alcoholism Hippuric acid+urine 0 0 -0.53 kegg urine_cometabolism NA 0.361 no no no no no no Aldosterone synthesis and secretion Hippuric acid+urine 0 0 -0.605384615 kegg urine_cometabolism NA 0.361 no up up no no no Allograft rejection Hippuric acid+urine 0 -0.457894737 0 kegg urine_cometabolism NA 0.361 no no no no no no Alzheimer disease Hippuric acid+urine 0 0 -0.596923077 kegg urine_cometabolism NA 0.361 no no no no no no Amphetamine addiction Hippuric acid+urine 0 0 -0.644615385 kegg urine_cometabolism NA 0.361 no no no no no no AMPK signaling pathway Hippuric acid+urine 0 0.471929825 0 kegg urine_cometabolism NA 0.361 no no no no no no Amyotrophic lateral sclerosis Hippuric acid+urine 0 0 -0.701538462 kegg urine_cometabolism NA 0.361 no no no no no no Anaerostipes Hippuric acid+urine 0.572079545 0 0 butyrate-producing Genus urine_cometabolism 0.568 0.361 no no no no no no Antigen processing and presentation Hippuric acid+urine 0 -0.729824561 0 kegg urine_cometabolism NA 0.361 no no no no no no Apelin signaling pathway Hippuric acid+urine 0.557894737 0 0 kegg urine_cometabolism NA 0.361 no no no no no no Arrhythmogenic right ventricular cardiomyopathy Hippuric acid+urine 0 0 -0.483846154 kegg urine_cometabolism NA 0.361 no up up no no no Asthma Hippuric acid+urine 0 -0.575438596 0 kegg urine_cometabolism NA 0.361 no no no no no no Autoimmune thyroid disease Hippuric acid+urine 0 -0.457894737 0 kegg urine_cometabolism NA 0.361 no no no no no no Autophagy - animal Hippuric acid+urine 0 0 0.461538462 kegg urine_cometabolism NA 0.361 no no no no no no Bacterial invasion of epithelial cells Hippuric acid+urine 0 -0.685964912 -0.463846154 kegg urine_cometabolism NA 0.361 no no no no no no Breast cancer Hippuric acid+urine 0 0.552631579 0 kegg urine_cometabolism NA 0.361 no no no no no no C-type lectin receptor signaling pathway Hippuric acid+urine 0 0 0.416923077 kegg urine_cometabolism NA 0.361 no no no no no no CA+stool Hippuric acid+urine 0 0 -0.661506708 stool_bileacids urine_cometabolism 0.827 0.361 no no no no no no Carbon metabolism Hippuric acid+urine 0 -0.631578947 0 kegg urine_cometabolism NA 0.361 no no no no no no Cardiac muscle contraction Hippuric acid+urine 0 0 -0.598461538 kegg urine_cometabolism NA 0.361 no no up no no no CDCA+stool Hippuric acid+urine 0 0 -0.591331269 stool_bileacids urine_cometabolism 0.663 0.361 no no no no no no Chemical carcinogenesis - receptor activation Hippuric acid+urine 0 0.659649123 0 kegg urine_cometabolism NA 0.361 no no no no no no Choline metabolism in cancer Hippuric acid+urine 0 0.629824561 0 kegg urine_cometabolism NA 0.361 no no no no no no Circadian entrainment Hippuric acid+urine 0 0 -0.806153846 kegg urine_cometabolism NA 0.361 no up up no no no Clostridium Hippuric acid+urine 0 -0.633432613 0 Genus urine_cometabolism 0.925 0.361 no no no no no no Cocaine addiction Hippuric acid+urine 0 0 -0.446153846 kegg urine_cometabolism NA 0.361 no no no no no no Collinsella Hippuric acid+urine 0 0 -0.44611047 Genus urine_cometabolism 0.128 0.361 no no no no no no Coprococcus Hippuric acid+urine 0 0 0.525470085 butyrate-producing Genus urine_cometabolism 0.612 0.361 no no no no no no Coronavirus disease - COVID-19 Hippuric acid+urine 0.466666667 0 0 kegg urine_cometabolism NA 0.361 no no no no no no Cortisol synthesis and secretion Hippuric acid+urine 0 0.522807018 -0.553076923 kegg urine_cometabolism NA 0.361 no no up no no no Cushing syndrome Hippuric acid+urine 0 0.543859649 0 kegg urine_cometabolism NA 0.361 no no up no no no d18:1-16:1-SM+blood Hippuric acid+urine 0 0 -0.438961039 serum_phospholipids urine_cometabolism 0.2 0.361 no no no no no no d18:1-18:1-SM+blood Hippuric acid+urine 0 0 -0.536363636 serum_phospholipids urine_cometabolism 0.916 0.361 no no no no no no Diabetic cardiomyopathy Hippuric acid+urine 0 0 -0.602307692 kegg urine_cometabolism NA 0.361 no no no no no no Dilated cardiomyopathy Hippuric acid+urine 0 0 -0.577692308 kegg urine_cometabolism NA 0.361 no up up no no no DMG+blood Hippuric acid+urine 0 -0.565934066 0 serum_choline urine_cometabolism 0.909 0.361 no no no no no no Dopaminergic synapse Hippuric acid+urine 0 0 -0.69 kegg urine_cometabolism NA 0.361 no up no no no no EGFR tyrosine kinase inhibitor resistance Hippuric acid+urine 0.664912281 0 0 kegg urine_cometabolism NA 0.361 no no no no no no Endocrine and other factor-regulated calcium reabsorption Hippuric acid+urine 0 0 -0.689230769 kegg urine_cometabolism NA 0.361 no no no no no no Endocrine resistance Hippuric acid+urine 0 0.601754386 -0.422307692 kegg urine_cometabolism NA 0.361 no no no no no no EPA+blood Hippuric acid+urine 0 0 0.446753247 serum_ARA urine_cometabolism 0.212 0.361 no no no no no no Epstein-Barr virus infection Hippuric acid+urine 0 -0.707017544 0 kegg urine_cometabolism NA 0.361 no no no no no no Estrogen signaling pathway Hippuric acid+urine 0 0 -0.483846154 kegg urine_cometabolism NA 0.361 no no no no no no Fluid shear stress and atherosclerosis Hippuric acid+urine 0 -0.705263158 0 kegg urine_cometabolism NA 0.361 no no no no no no Focal adhesion Hippuric acid+urine 0 -0.563157895 -0.478461538 kegg urine_cometabolism NA 0.361 no up up no no no FoxO signaling pathway Hippuric acid+urine 0 0.619298246 0 kegg urine_cometabolism NA 0.361 no no no no no no Gap junction Hippuric acid+urine 0 0 -0.484615385 kegg urine_cometabolism NA 0.361 no no no no no no Gastric acid secretion Hippuric acid+urine 0 0 -0.54 kegg urine_cometabolism NA 0.361 no no no no no no Gastric cancer Hippuric acid+urine 0.487719298 0.621052632 0 kegg urine_cometabolism NA 0.361 no no no no no no GCDCA+blood Hippuric acid+urine 0 0 -0.458441558 serum_bileacids urine_cometabolism 0.31 0.361 no no no no no no Glucagon signaling pathway Hippuric acid+urine 0 0 -0.403846154 kegg urine_cometabolism NA 0.361 no no no no no no Glycolysis / Gluconeogenesis Hippuric acid+urine 0 -0.512280702 0 kegg urine_cometabolism NA 0.361 no no no no no no GnRH signaling pathway Hippuric acid+urine 0 0 -0.587692308 kegg urine_cometabolism NA 0.361 no no no no no no Graft-versus-host disease Hippuric acid+urine 0 -0.457894737 0 kegg urine_cometabolism NA 0.361 no no no no no no "Growth hormone synthesis, secretion and action" Hippuric acid+urine 0 0.649122807 0 kegg urine_cometabolism NA 0.361 no no no no no no HCA+blood Hippuric acid+urine 0 0 -0.547747604 serum_bileacids urine_cometabolism 0.544 0.361 no no no no no no HDCA+stool Hippuric acid+urine 0 0.766666667 0 stool_bileacids urine_cometabolism 0.176 0.361 no no no no no no Herpes simplex virus 1 infection Hippuric acid+urine 0 -0.635087719 0 kegg urine_cometabolism NA 0.361 no no no no no no HIF-1 signaling pathway Hippuric acid+urine 0.622807018 0 0 kegg urine_cometabolism NA 0.361 no no no no no no Hippo signaling pathway Hippuric acid+urine 0 0 -0.467692308 kegg urine_cometabolism NA 0.361 no no no no no no Human cytomegalovirus infection Hippuric acid+urine 0 -0.626315789 0 kegg urine_cometabolism NA 0.361 no no dn no no no Human immunodeficiency virus 1 infection Hippuric acid+urine 0 -0.656140351 0 kegg urine_cometabolism NA 0.361 no no no no no no Human T-cell leukemia virus 1 infection Hippuric acid+urine 0 -0.661403509 0 kegg urine_cometabolism NA 0.361 no no no no no no Huntington disease Hippuric acid+urine 0 0 -0.657692308 kegg urine_cometabolism NA 0.361 no no no no no no Hypertrophic cardiomyopathy Hippuric acid+urine 0 -0.473684211 -0.475384615 kegg urine_cometabolism NA 0.361 no up up no no no Inflammatory mediator regulation of TRP channels Hippuric acid+urine 0 0 -0.628461538 kegg urine_cometabolism NA 0.361 no no no no no no Influenza A Hippuric acid+urine 0 -0.564912281 0 kegg urine_cometabolism NA 0.361 no no no no no no Insulin secretion Hippuric acid+urine 0 0 -0.517692308 yes kegg urine_cometabolism NA 0.361 no up up no no no Insulin signaling pathway Hippuric acid+urine 0.610526316 0 0 kegg urine_cometabolism NA 0.361 no no no no no no JAK-STAT signaling pathway Hippuric acid+urine 0 0.533333333 0.427692308 kegg urine_cometabolism NA 0.361 no no no no no no L-Aspartic acid+blood Hippuric acid+urine 0 0 0.45974026 yes serum_aminoacids urine_cometabolism 0.0226 0.361 up up no no no no L-Glutamic acid+blood Hippuric acid+urine 0 0 0.511688312 yes serum_aminoacids urine_cometabolism 6.20E-05 0.361 up up no no no no L-Lysine+blood Hippuric acid+urine 0 0 0.475324675 yes serum_aminoacids urine_cometabolism 0.0107 0.361 no up no no no no L-Ornithine+blood Hippuric acid+urine 0 0 0.466233766 serum_aminoacids urine_cometabolism 0.175 0.361 no no no no no no Lachnospira Hippuric acid+urine 0 -0.485964912 0 butyrate-producing Genus urine_cometabolism 0.279 0.361 no no no no no no Leishmaniasis Hippuric acid+urine 0 -0.480701754 0 kegg urine_cometabolism NA 0.361 no no no no no no Leukocyte transendothelial migration Hippuric acid+urine 0 -0.759649123 0 kegg urine_cometabolism NA 0.361 no no no no no no Long-term depression Hippuric acid+urine 0 0 -0.563846154 kegg urine_cometabolism NA 0.361 no no no no no no Longevity regulating pathway Hippuric acid+urine 0 0.547368421 0 kegg urine_cometabolism NA 0.361 no no no no no no Lysosome Hippuric acid+urine 0 -0.585964912 0 kegg urine_cometabolism NA 0.361 no no no no no no MAPK signaling pathway Hippuric acid+urine 0 0.521052632 0 kegg urine_cometabolism NA 0.361 no no no no no no Melanogenesis Hippuric acid+urine 0 0 -0.679230769 kegg urine_cometabolism NA 0.361 no no no no no no Morphine addiction Hippuric acid+urine 0 0 -0.68 kegg urine_cometabolism NA 0.361 no up up no no no mTOR signaling pathway Hippuric acid+urine 0.661403509 0 0 kegg urine_cometabolism NA 0.361 no no no no no no n3+blood Hippuric acid+urine 0 0 0.515584416 serum_fattyacid urine_cometabolism 0.806 0.361 no no no no no no Neutrophil extracellular trap formation Hippuric acid+urine 0 -0.471929825 0 kegg urine_cometabolism NA 0.361 no no no no no no NF-kappa B signaling pathway Hippuric acid+urine 0 0 0.511538462 kegg urine_cometabolism NA 0.361 no no no no no no NOD-like receptor signaling pathway Hippuric acid+urine 0 0 0.439230769 kegg urine_cometabolism NA 0.361 no no no no no no Non-alcoholic fatty liver disease Hippuric acid+urine 0 0 -0.690769231 kegg urine_cometabolism NA 0.361 no no no no no no Non-small cell lung cancer Hippuric acid+urine 0 0.545614035 0 kegg urine_cometabolism NA 0.361 no no no no no no nutriCA+blood Hippuric acid+urine 0 0 -0.481098573 serum_bileacids urine_cometabolism 0.726 0.361 no no no no no no nutriCA+stool Hippuric acid+urine 0 0 -0.554179567 stool_bileacids urine_cometabolism 0.481 0.361 no no no no no no Oxidative phosphorylation Hippuric acid+urine 0 0 -0.64 kegg urine_cometabolism NA 0.361 no no no no no no Oxytocin signaling pathway Hippuric acid+urine 0 -0.6 -0.403846154 kegg urine_cometabolism NA 0.361 no no no no no no p53 signaling pathway Hippuric acid+urine 0 0.784210526 0 kegg urine_cometabolism NA 0.361 no no no no no no Pancreatic secretion Hippuric acid+urine 0 0 -0.727692308 kegg urine_cometabolism NA 0.361 no no no no no no Parabacteroides Hippuric acid+urine 0.460150376 0 0 Genus urine_cometabolism 4.19E-05 0.361 no up up no no no "Parathyroid hormone synthesis, secretion and action" Hippuric acid+urine 0 0 -0.505384615 kegg urine_cometabolism NA 0.361 no no no no no no Parkinson disease Hippuric acid+urine 0 0 -0.496153846 kegg urine_cometabolism NA 0.361 no no no no no no Pathogenic Escherichia coli infection Hippuric acid+urine 0 -0.598245614 0 kegg urine_cometabolism NA 0.361 no no no no no no Pathways in cancer Hippuric acid+urine 0 0.496491228 0 kegg urine_cometabolism NA 0.361 no no no no no no Pathways of neurodegeneration - multiple diseases Hippuric acid+urine 0 0 -0.460769231 kegg urine_cometabolism NA 0.361 no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Hippuric acid+urine 0 0 0.463076923 kegg urine_cometabolism NA 0.361 no no no no no no Phagosome Hippuric acid+urine 0 -0.519298246 0 kegg urine_cometabolism NA 0.361 no no no no no no Phosphatidylinositol signaling system Hippuric acid+urine 0 0.547368421 0 kegg urine_cometabolism NA 0.361 no no no no no no Platelet activation Hippuric acid+urine 0 -0.496491228 -0.555384615 kegg urine_cometabolism NA 0.361 no no no no no no Platinum drug resistance Hippuric acid+urine 0 0.757894737 0 kegg urine_cometabolism NA 0.361 no no no no no no Prevotella Hippuric acid+urine 0 0.625039386 0 acetate-producing Genus urine_cometabolism 0.287 0.361 no no no no no no Prion disease Hippuric acid+urine 0 0 -0.614615385 kegg urine_cometabolism NA 0.361 no no no no no no Progesterone-mediated oocyte maturation Hippuric acid+urine 0 0.710526316 0 kegg urine_cometabolism NA 0.361 no no no no no no Rap1 signaling pathway Hippuric acid+urine 0 -0.519298246 -0.533076923 kegg urine_cometabolism NA 0.361 no no no no no no Ras signaling pathway Hippuric acid+urine 0.540350877 0 0 yes kegg urine_cometabolism NA 0.361 no up up no no no Regulation of actin cytoskeleton Hippuric acid+urine 0 -0.594736842 -0.617692308 kegg urine_cometabolism NA 0.361 no no no no no no Regulation of lipolysis in adipocytes Hippuric acid+urine 0 0 -0.553846154 kegg urine_cometabolism NA 0.361 no no no no no no Renal cell carcinoma Hippuric acid+urine 0.49122807 0 0 kegg urine_cometabolism NA 0.361 no no no no no no Renin secretion Hippuric acid+urine 0 0 -0.646923077 kegg urine_cometabolism NA 0.361 no no no no no no Retrograde endocannabinoid signaling Hippuric acid+urine 0 0 -0.544615385 kegg urine_cometabolism NA 0.361 no no up no no no Ribosome Hippuric acid+urine 0.466666667 0 0 kegg urine_cometabolism NA 0.361 no no no no no no RIG-I-like receptor signaling pathway Hippuric acid+urine 0 0 0.417692308 kegg urine_cometabolism NA 0.361 no no no no no no Salivary secretion Hippuric acid+urine 0 0 -0.460769231 kegg urine_cometabolism NA 0.361 no no no no no no Salmonella infection Hippuric acid+urine 0 -0.631578947 0 kegg urine_cometabolism NA 0.361 no no no no no no Serotonergic synapse Hippuric acid+urine 0 0 -0.424615385 kegg urine_cometabolism NA 0.361 no no no no no no Signaling pathways regulating pluripotency of stem cells Hippuric acid+urine 0 0.584210526 0 kegg urine_cometabolism NA 0.361 no no no no no no Spliceosome Hippuric acid+urine 0 0.696491228 0 kegg urine_cometabolism NA 0.361 no no no no no no Staphylococcus aureus infection Hippuric acid+urine 0 -0.584210526 0 kegg urine_cometabolism NA 0.361 up no no no no no Systemic lupus erythematosus Hippuric acid+urine 0 -0.578947368 0 kegg urine_cometabolism NA 0.361 no no no no no no TGF-beta signaling pathway Hippuric acid+urine 0.461403509 0 0 kegg urine_cometabolism NA 0.361 no no no no no no Thermogenesis Hippuric acid+urine 0 0 -0.653076923 kegg urine_cometabolism NA 0.361 no no no no no no Thyroid hormone synthesis Hippuric acid+urine 0 0 -0.433846154 kegg urine_cometabolism NA 0.361 no no no no no no Tight junction Hippuric acid+urine 0 -0.650877193 -0.432307692 kegg urine_cometabolism NA 0.361 no no no no no no Toxoplasmosis Hippuric acid+urine -0.677192982 0 0 kegg urine_cometabolism NA 0.361 no no no no no no Tuberculosis Hippuric acid+urine 0 -0.489473684 0 kegg urine_cometabolism NA 0.361 no no dn no no no Vascular smooth muscle contraction Hippuric acid+urine 0 0 -0.688461538 kegg urine_cometabolism NA 0.361 no no no no no no Vasopressin-regulated water reabsorption Hippuric acid+urine 0 0 -0.734615385 kegg urine_cometabolism NA 0.361 no no no no no no Vibrio cholerae infection Hippuric acid+urine 0 0 -0.503846154 kegg urine_cometabolism NA 0.361 no no no no no no Viral myocarditis Hippuric acid+urine 0 -0.487719298 0 kegg urine_cometabolism NA 0.361 no no no no no no Viral protein interaction with cytokine and cytokine receptor Hippuric acid+urine 0 -0.459649123 -0.589230769 kegg urine_cometabolism NA 0.361 no no no no no no Yersinia infection Hippuric acid+urine 0 -0.554385965 0 kegg urine_cometabolism NA 0.361 no no no no no no Arginine and proline metabolism Histidine metabolism 0.442608696 0 0 kegg kegg NA NA no up no no no no Ascorbate and aldarate metabolism Histidine metabolism 0.846086957 0.598814229 0.699356499 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Histidine metabolism 0.586956522 0 0.464864865 kegg kegg NA NA no no no no no no Fatty acid degradation Histidine metabolism 0.54 0 0.626254826 kegg kegg NA NA no no no no no no Fatty acid elongation Histidine metabolism 0.650434783 0.423913043 0.484169884 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Histidine metabolism 0.586956522 0 0.597940798 kegg kegg NA NA no no no no no no Galactose metabolism Histidine metabolism 0.768695652 0 0.611068211 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Histidine metabolism 0.485217391 0 0.616216216 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Histidine metabolism 0.493043478 0 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Histidine metabolism 0.679130435 0.427865613 0.565250965 kegg kegg NA NA no no no no no no Pyrimidine metabolism Histidine metabolism 0.652173913 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Histidine metabolism 0 0.460474308 0.404633205 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Histidine metabolism 0.651304348 0.591897233 0.517889318 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Histidine metabolism 0.499130435 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Histidine metabolism 0.752173913 0.483201581 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Histidine metabolism 0.653043478 0.46541502 0.564736165 kegg kegg NA NA no no no no no no WAL_1855D Holdemania 0.402433251 0 0 Genus Genus 0.916 0.289 no no no no no no 12-ketoDCA+blood HOMA-IR+clinic 0 -0.541210939 0 serum_bileacids clinic 0.517 1.68E-06 no no no up up no 16:0/18:0-PC+blood HOMA-IR+clinic 0 -0.517857143 0 serum_phospholipids clinic 0.521 1.68E-06 no no no up up no 16:0+blood HOMA-IR+clinic 0 0 0.441538462 yes serum_fattyacid clinic 0.00876 1.68E-06 up no no up up no 16:1+blood HOMA-IR+clinic 0 0.567857143 0 yes serum_fattyacid clinic 0.0186 1.68E-06 no no dn up up no 18:0/20:3-PC+blood HOMA-IR+clinic 0 0 0.436153846 serum_phospholipids clinic 0.0682 1.68E-06 no up no up up no 18:0/20:3-PI+blood HOMA-IR+clinic 0 0.625 0 serum_phospholipids clinic 0.377 1.68E-06 no no no up up no 18:1/18:1-PE+blood HOMA-IR+clinic 0 0.521428571 0 serum_phospholipids clinic 1.03E-05 1.68E-06 up up no up up no 18:2-LPC+blood HOMA-IR+clinic 0 -0.542857143 -0.413846154 serum_phospholipids clinic 0.00743 1.68E-06 dn no up up up no 18:2-LPE+blood HOMA-IR+clinic 0 0 -0.476153846 serum_phospholipids clinic 0.112 1.68E-06 no no no up up no 20:2/18:0-PC+blood HOMA-IR+clinic 0 0 0.426153846 serum_phospholipids clinic 0.0427 1.68E-06 no up no up up no 20:3n6+blood HOMA-IR+clinic 0 0.557142857 0.454615385 serum_fattyacid clinic 0.0884 1.68E-06 up no no up up no 4-hydroxybenzoic acid+urine HOMA-IR+clinic 0 -0.62254902 -0.485384615 urine_cometabolism clinic 0.52 1.68E-06 no no no up up no 9-HODE+blood HOMA-IR+clinic 0 -0.546428571 0 serum_ARA clinic 0.297 1.68E-06 no no no up up no C-peptide HOMA-IR+clinic 0 0.592320723 0 DM-assocaited hormones clinic 0.228 1.68E-06 no no no up up no CDCA+stool HOMA-IR+clinic 0 0.709090909 0 stool_bileacids clinic 0.663 1.68E-06 no no no up up no GLCA+blood HOMA-IR+clinic 0 0 -0.411408253 serum_bileacids clinic 0.319 1.68E-06 no no no up up no GUDCA+stool HOMA-IR+clinic 0 -0.629285309 0 yes stool_bileacids clinic 0.0085 1.68E-06 no dn no up up no HDCA+blood HOMA-IR+clinic 0 -0.541210939 0 serum_bileacids clinic 0.483 1.68E-06 no no no up up no iso-LCA+blood HOMA-IR+clinic 0 -0.520922988 0 serum_bileacids clinic 0.507 1.68E-06 no no no up up no L-Homocystine+blood HOMA-IR+clinic 0 -0.535714286 0 serum_aminoacids clinic 0.197 1.68E-06 no no no up up no L-Proline+blood HOMA-IR+clinic 0 0.664285714 0 yes serum_aminoacids clinic 0.00265 1.68E-06 up up no up up no L-Tyrosine+blood HOMA-IR+clinic 0 0.689285714 0 yes serum_aminoacids clinic 0.00913 1.68E-06 up up no up up no Legionellosis HOMA-IR+clinic 0 -0.438961039 0 kegg clinic NA 1.68E-06 no no no up up no Leptin HOMA-IR+clinic 0 0 0.506799083 DM-assocaited hormones clinic 0.706 1.68E-06 no no no up up no Methanobrevibacter HOMA-IR+clinic 0 -0.499010879 0 Genus clinic 0.629 1.68E-06 no no no up up no Parabacteroides HOMA-IR+clinic 0 -0.483907397 0 Genus clinic 4.19E-05 1.68E-06 no up up up up no Paraprevotella HOMA-IR+clinic 0 0.5244252 0 Genus clinic 0.118 1.68E-06 no no no up up no Roseburia HOMA-IR+clinic 0 0.532053114 0 butyrate-producing Genus clinic 0.495 1.68E-06 no no no up up no total_stool_scfa+stool HOMA-IR+clinic 0 -0.636363636 0 stool_scfa clinic 0.0534 1.68E-06 dn no up up up no 13-HODE+blood HOMA-¦Â+clinic 0 0 -0.628461538 serum_ARA clinic 0.32 3.22E-07 no no no dn dn no 18:0/22:6-PC+blood HOMA-¦Â+clinic 0.583075335 0 0 serum_phospholipids clinic 0.0775 3.22E-07 no no up dn dn no 18:1-LPC+blood HOMA-¦Â+clinic -0.512899897 0 0 serum_phospholipids clinic 0.179 3.22E-07 no no no dn dn no 18:1-LPE+blood HOMA-¦Â+clinic -0.477812178 0 0 serum_phospholipids clinic 0.117 3.22E-07 no no no dn dn no 18:2-LPC+blood HOMA-¦Â+clinic 0 -0.632142857 0 serum_phospholipids clinic 0.00743 3.22E-07 dn no up dn dn no 18:2-LPE+blood HOMA-¦Â+clinic 0 0 -0.433076923 serum_phospholipids clinic 0.112 3.22E-07 no no no dn dn no 18:2/18:2-PC+blood HOMA-¦Â+clinic 0 -0.696428571 0 serum_phospholipids clinic 1.98E-05 3.22E-07 dn up up dn dn no 8-HETE+blood HOMA-¦Â+clinic 0 0 -0.456153846 serum_ARA clinic 0.741 3.22E-07 no no no dn dn no Blautia HOMA-¦Â+clinic 0 0.653303219 -0.405773877 acetate-producing Genus clinic 1.36E-05 3.22E-07 up dn dn dn dn no CA+stool HOMA-¦Â+clinic 0 0.745454545 0 stool_bileacids clinic 0.827 3.22E-07 no no no dn dn no Carbon metabolism HOMA-¦Â+clinic 0 0.444155844 0 kegg clinic NA 3.22E-07 no no no dn dn no CDCA+stool HOMA-¦Â+clinic 0 0.863636364 0 stool_bileacids clinic 0.663 3.22E-07 no no no dn dn no Clostridium HOMA-¦Â+clinic 0.448727466 0.524145742 0 Genus clinic 0.925 3.22E-07 no no no dn dn no Collinsella HOMA-¦Â+clinic 0.521373873 0 0 Genus clinic 0.128 3.22E-07 no no no dn dn no Coprococcus HOMA-¦Â+clinic 0 0.532467532 0 butyrate-producing Genus clinic 0.612 3.22E-07 no no no dn dn no d18:1-14:0-SM+blood HOMA-¦Â+clinic 0.531475748 0 0 serum_phospholipids clinic 0.94 3.22E-07 no no no dn dn no Dorea HOMA-¦Â+clinic 0 0.613950886 0 Genus clinic 0.00362 3.22E-07 up no dn dn dn no Faecalibacterium HOMA-¦Â+clinic 0 0.457933371 0 butyrate-producing Genus clinic 0.0039 3.22E-07 no dn dn dn dn no GCA+stool HOMA-¦Â+clinic 0 0.763636364 0 stool_bileacids clinic 0.0809 3.22E-07 no no no dn dn no GCDCA+stool HOMA-¦Â+clinic 0.632352941 0.763636364 0 yes stool_bileacids clinic 0.0471 3.22E-07 no dn no dn dn no GDCA+blood HOMA-¦Â+clinic 0 -0.521428571 0 serum_bileacids clinic 0.632 3.22E-07 no no no dn dn no GDCA+stool HOMA-¦Â+clinic 0 0.797268583 0 stool_bileacids clinic 0.656 3.22E-07 no no no dn dn no GPC+blood HOMA-¦Â+clinic 0.500515996 0 0 serum_choline clinic 0.00427 3.22E-07 no up up dn dn no "Growth hormone synthesis, secretion and action" HOMA-¦Â+clinic 0 -0.468831169 0 kegg clinic NA 3.22E-07 no no no dn dn no Hippuric acid+urine HOMA-¦Â+clinic 0 0 -0.412307692 urine_cometabolism clinic 0.361 3.22E-07 no no no dn dn no IL-1ra HOMA-¦Â+clinic 0 0.489473684 0 yes serum_cytokines clinic 0.0288 3.22E-07 no up no dn dn no Indole-3-Acetic acid+stool HOMA-¦Â+clinic 0 -0.790909091 0 stool_cometabolism clinic 0.304 3.22E-07 no no no dn dn no Indole-3-Acetic acid+urine HOMA-¦Â+clinic -0.494324045 0 0 urine_cometabolism clinic 0.657 3.22E-07 no no no dn dn no iso-LCA+blood HOMA-¦Â+clinic 0 -0.552816232 0 serum_bileacids clinic 0.507 3.22E-07 no no no dn dn no L-Homocystine+blood HOMA-¦Â+clinic -0.543859649 0 0 serum_aminoacids clinic 0.197 3.22E-07 no no no dn dn no L-Methionine+blood HOMA-¦Â+clinic 0 0.560714286 0 serum_aminoacids clinic 0.626 3.22E-07 no no no dn dn no L-Phenylalanine+blood HOMA-¦Â+clinic 0 0.65 0 yes serum_aminoacids clinic 0.0103 3.22E-07 up up no dn dn no L-Proline+blood HOMA-¦Â+clinic 0 0.560714286 0 yes serum_aminoacids clinic 0.00265 3.22E-07 up up no dn dn no L-Tryptophan+blood HOMA-¦Â+clinic 0 0.628571429 0 serum_aminoacids clinic 0.164 3.22E-07 no no no dn dn no L-Tyrosine+blood HOMA-¦Â+clinic 0 0.825 0 yes serum_aminoacids clinic 0.00913 3.22E-07 up up no dn dn no Leptin HOMA-¦Â+clinic 0.529644269 0.518915867 0 DM-assocaited hormones clinic 0.706 3.22E-07 no no no dn dn no Longevity regulating pathway - multiple species HOMA-¦Â+clinic 0 0.475324675 0 kegg clinic NA 3.22E-07 no no no dn dn no PUFA/MUFA+blood HOMA-¦Â+clinic 0.525283798 0 0 serum_fattyacid clinic 0.00108 3.22E-07 dn no up dn dn no Regulation of actin cytoskeleton HOMA-¦Â+clinic 0 0.512987013 0 kegg clinic NA 3.22E-07 no no no dn dn no Roseburia HOMA-¦Â+clinic 0 0.455803464 0 butyrate-producing Genus clinic 0.495 3.22E-07 no no no dn dn no TDCA+blood HOMA-¦Â+clinic 0 -0.540058935 0 yes serum_bileacids clinic 0.155 3.22E-07 no up no dn dn no TXB2+blood HOMA-¦Â+clinic 0.524303086 0 0 yes serum_ARA clinic 0.0644 3.22E-07 dn no no dn dn no UDCA+stool HOMA-¦Â+clinic 0 0.881818182 0 stool_bileacids clinic 0.266 3.22E-07 no no no dn dn no Valine+blood HOMA-¦Â+clinic 0 0.578571429 0 yes serum_aminoacids clinic 1.22E-06 3.22E-07 up up no dn dn no ABC transporters Homologous recombination 0.588695652 0.735177866 0 kegg kegg NA NA no up up no no no Amino sugar and nucleotide sugar metabolism Homologous recombination 0.491304348 0.690711462 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Homologous recombination 0.708695652 0.694664032 0.663063063 kegg kegg NA NA no no no no no no Antifolate resistance Homologous recombination 0.415652174 0.473320158 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Homologous recombination 0 0 -0.421621622 kegg kegg NA NA no up no no no no Ascorbate and aldarate metabolism Homologous recombination 0 0 0.445302445 kegg kegg NA NA no no no no no no Basal transcription factors Homologous recombination 0.536521739 0.649209486 0.817760618 kegg kegg NA NA no no no no no no Base excision repair Homologous recombination 0.807826087 0.692687747 0.852509653 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Homologous recombination 0 0 -0.53024453 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Homologous recombination 0 0.467391304 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Homologous recombination 0.633913043 0 0.457142857 kegg kegg NA NA no no no no no no Butanoate metabolism Homologous recombination 0.409565217 0 0.594594595 kegg kegg NA NA no no no no no no Carbon metabolism Homologous recombination 0 -0.437747036 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Homologous recombination 0.44 0 0.537194337 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Homologous recombination 0.696521739 0 0.722779923 kegg kegg NA NA no no no no no no DNA replication Homologous recombination 0.762608696 0.479249012 0.779407979 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Homologous recombination 0 0 0.408236808 kegg kegg NA NA no no no no no no Ether lipid metabolism Homologous recombination 0 0 0.613384813 kegg kegg NA NA no no no no no no Fatty acid elongation Homologous recombination 0 0 0.412355212 kegg kegg NA NA no no no no no no Glycerolipid metabolism Homologous recombination 0 0.661067194 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Homologous recombination 0 0.754940711 0.551866152 kegg kegg NA NA no no up no no no Glycosaminoglycan biosynthesis - keratan sulfate Homologous recombination -0.429565217 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Homologous recombination -0.654782609 0 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Homologous recombination 0 0.481225296 0.452252252 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Homologous recombination 0.691304348 0.768774704 0.405920206 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Homologous recombination 0.483478261 0.70256917 0.543371943 kegg kegg NA NA no no no no no no Lysine degradation Homologous recombination 0.409565217 0.71541502 0.546203346 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Homologous recombination 0 0.470355731 0.425740026 kegg kegg NA NA no no no no no no Mismatch repair Homologous recombination 0.74 0.47826087 0.690862291 kegg kegg NA NA no no no no no no mRNA surveillance pathway Homologous recombination 0 0 0.534105534 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Homologous recombination 0.693913043 0.527667984 0.543629344 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Homologous recombination 0.513913043 0 0.654568855 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Homologous recombination 0 0 -0.531016731 kegg kegg NA NA no no no no no no Nucleotide excision repair Homologous recombination 0.803478261 0.583992095 0.87027027 kegg kegg NA NA no no no no no no One carbon pool by folate Homologous recombination 0.77826087 0.518774704 0.71969112 kegg kegg NA NA no no no no no no Other glycan degradation Homologous recombination 0 0.551383399 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Homologous recombination 0.485217391 0.798418972 0.726640927 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Homologous recombination 0.423478261 0 0.524581725 kegg kegg NA NA no no no no no no Pentose phosphate pathway Homologous recombination 0 -0.546442688 -0.562419562 kegg kegg NA NA no no no no no no Platinum drug resistance Homologous recombination 0.710434783 0.81027668 0.786357786 kegg kegg NA NA no no no no no no PPAR signaling pathway Homologous recombination 0 0 -0.649163449 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Homologous recombination 0.664347826 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Homologous recombination 0.695652174 0 0.653281853 kegg kegg NA NA no no no no no no Pyrimidine metabolism Homologous recombination 0.462608696 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Homologous recombination 0.706086957 0 0.611068211 kegg kegg NA NA no no no no no no Retinol metabolism Homologous recombination 0.603478261 0.475296443 0.59021879 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Homologous recombination 0.68173913 0.745059289 0.813127413 kegg kegg NA NA no no no no no no RNA degradation Homologous recombination 0 0 0.586357786 kegg kegg NA NA no no no no no no RNA polymerase Homologous recombination 0.504347826 0.612648221 0.685456885 kegg kegg NA NA no no no no no no RNA transport Homologous recombination 0.670434783 0 0.44041184 kegg kegg NA NA no no no no no no Selenocompound metabolism Homologous recombination 0.536521739 0.840909091 0.775032175 kegg kegg NA NA no no no no no no Sphingolipid metabolism Homologous recombination -0.705217391 -0.42687747 0 kegg kegg NA NA no no no no no no Spliceosome Homologous recombination 0.751304348 0.839920949 0.762419562 kegg kegg NA NA no no no no no no Steroid biosynthesis Homologous recombination 0 0 0.628056628 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Homologous recombination 0 0 0.490604891 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Homologous recombination 0.732173913 0.564229249 0.700643501 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Homologous recombination 0 0.554347826 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Homologous recombination 0.532173913 0.552371542 0.674388674 kegg kegg NA NA no no no no no no Thiamine metabolism Homologous recombination 0.525217391 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Homologous recombination 0.431304348 0 0.475418275 kegg kegg NA NA no up no no no no Tyrosine metabolism Homologous recombination 0 0 0.424710425 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Homologous recombination 0.586086957 0.509881423 0.653796654 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Homologous recombination 0.617391304 0 0.642213642 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Homologous recombination 0.43826087 0 0.605920206 kegg kegg NA NA no no no no no no 16:0/18:1-PC+blood Homovanillic acid+urine -0.615196078 0 0 serum_phospholipids urine_cometabolism 6.15E-07 0.45 up up up no no no 16:0/18:2-PC+blood Homovanillic acid+urine -0.524509804 0 0 serum_phospholipids urine_cometabolism 3.24E-06 0.45 no up up no no no 16:0/18:2-PI+blood Homovanillic acid+urine 0.664215686 0 0 serum_phospholipids urine_cometabolism 0.269 0.45 no no no no no no 16:0/20:3-PC+blood Homovanillic acid+urine -0.504901961 -0.642857143 0 serum_phospholipids urine_cometabolism 5.43E-06 0.45 no up up no no no 16:0/20:4-PI+blood Homovanillic acid+urine 0.781862745 0 0 serum_phospholipids urine_cometabolism 0.558 0.45 no no no no no no 18:0-LPC+blood Homovanillic acid+urine 0.534313725 0 0 serum_phospholipids urine_cometabolism 0.554 0.45 no no no no no no 18:0-LPE+blood Homovanillic acid+urine 0.62745098 0 0.464935065 serum_phospholipids urine_cometabolism 0.491 0.45 no no no no no no 18:0/16:0-PC+blood Homovanillic acid+urine -0.571078431 0 0 serum_phospholipids urine_cometabolism 9.64E-07 0.45 up up up no no no 18:0/18:2-PC+blood Homovanillic acid+urine -0.507352941 0 0 serum_phospholipids urine_cometabolism 1.74E-06 0.45 no up up no no no 18:0/20:3-PC+blood Homovanillic acid+urine 0 0 0.438961039 serum_phospholipids urine_cometabolism 0.0682 0.45 no up no no no no 18:0/20:5-PC+blood Homovanillic acid+urine -0.553921569 0 0 serum_phospholipids urine_cometabolism 0.17 0.45 no no no no no no 18:1/16:0-PC+blood Homovanillic acid+urine -0.524509804 0 0 serum_phospholipids urine_cometabolism 2.43E-05 0.45 no up up no no no 18:1/18:0-PC+blood Homovanillic acid+urine -0.556372549 0 0 serum_phospholipids urine_cometabolism 1.83E-06 0.45 no up up no no no 18:1/18:1-PC+blood Homovanillic acid+urine -0.546568627 -0.587912088 0 serum_phospholipids urine_cometabolism 1.34E-05 0.45 no up up no no no 18:1/18:2-PG+blood Homovanillic acid+urine 0 -0.56043956 0 serum_phospholipids urine_cometabolism 5.58E-07 0.45 no up up no no no 18:1/20:3-PC+blood Homovanillic acid+urine 0 -0.576923077 0 serum_phospholipids urine_cometabolism 0.00872 0.45 no up up no no no 18:3n3+blood Homovanillic acid+urine 0 0.604395604 0 serum_fattyacid urine_cometabolism 0.291 0.45 no no no no no no 18:3n6+blood Homovanillic acid+urine 0.492647059 0 0 serum_fattyacid urine_cometabolism 0.0463 0.45 up no dn no no no 2-hydroxyphenylacetic acid+urine Homovanillic acid+urine 0 0.557894737 0 urine_cometabolism urine_cometabolism 0.763 0.45 no no no no no no 20:0+blood Homovanillic acid+urine -0.517156863 -0.576923077 0 yes serum_fattyacid urine_cometabolism 0.000278 0.45 dn no up no no no 20:2/18:0-PC+blood Homovanillic acid+urine 0 0 0.464935065 serum_phospholipids urine_cometabolism 0.0427 0.45 no up no no no no 20:3/18:0-PC+blood Homovanillic acid+urine 0 0 0.435064935 serum_phospholipids urine_cometabolism 0.296 0.45 no no no no no no 20:3n6+blood Homovanillic acid+urine 0 -0.60989011 0 serum_fattyacid urine_cometabolism 0.0884 0.45 up no no no no no 22:6n3+blood Homovanillic acid+urine 0.531862745 0 0 serum_fattyacid urine_cometabolism 0.792 0.45 no no no no no no 24:0+blood Homovanillic acid+urine 0 -0.758241758 0 serum_fattyacid urine_cometabolism 0.034 0.45 dn no up no no no 4-hydroxy-3-methoxymandelic acid+urine Homovanillic acid+urine 0 0 0.662905983 urine_cometabolism urine_cometabolism 0.973 0.45 no no no no no no 4-hydroxybenzoic acid+stool Homovanillic acid+urine 0.538461538 0 0 stool_cometabolism urine_cometabolism 0.0536 0.45 no dn no no no no 4-hydroxybenzoic acid+urine Homovanillic acid+urine 0 0.5 0 urine_cometabolism urine_cometabolism 0.52 0.45 no no no no no no "9,10-EPOME+blood" Homovanillic acid+urine 0 0.737277176 0 serum_ARA urine_cometabolism 0.801 0.45 no no no no no no Acetic acid+stool Homovanillic acid+urine 0.652747253 0 0 yes stool_scfa urine_cometabolism 0.0656 0.45 dn no no no no no Acute myeloid leukemia Homovanillic acid+urine 0 0 -0.436153846 kegg urine_cometabolism NA 0.45 no no no no no no Alistipes Homovanillic acid+urine -0.724398412 0 0 Genus urine_cometabolism 0.0114 0.45 no up no no no no Anaerostipes Homovanillic acid+urine 0 0 0.462520223 butyrate-producing Genus urine_cometabolism 0.568 0.45 no no no no no no Biosynthesis of amino acids Homovanillic acid+urine 0 0.573684211 0 kegg urine_cometabolism NA 0.45 no no no no no no Breast cancer Homovanillic acid+urine 0 0 -0.447692308 kegg urine_cometabolism NA 0.45 no no no no no no Carbon metabolism Homovanillic acid+urine 0 0.540350877 0 kegg urine_cometabolism NA 0.45 no no no no no no Central carbon metabolism in cancer Homovanillic acid+urine 0.514035088 0 0 kegg urine_cometabolism NA 0.45 no no no no no no Chemokine signaling pathway Homovanillic acid+urine -0.470175439 0 0 kegg urine_cometabolism NA 0.45 no no no no no no Clostridium Homovanillic acid+urine 0 0.531354264 0 Genus urine_cometabolism 0.925 0.45 no no no no no no Colorectal cancer Homovanillic acid+urine 0 -0.503508772 -0.425384615 kegg urine_cometabolism NA 0.45 no no no no no no Coprococcus Homovanillic acid+urine 0.448120301 0 0 butyrate-producing Genus urine_cometabolism 0.612 0.45 no no no no no no Cytosolic DNA-sensing pathway Homovanillic acid+urine -0.59122807 0 0 kegg urine_cometabolism NA 0.45 no no no no no no d18:1-18:1-SM+blood Homovanillic acid+urine 0 0.697802198 0 serum_phospholipids urine_cometabolism 0.916 0.45 no no no no no no d18:1-20:1-SM+blood Homovanillic acid+urine 0 0.56043956 0 serum_phospholipids urine_cometabolism 0.0992 0.45 no no no no no no Ethanolamine+blood Homovanillic acid+urine 0 0 -0.501298701 serum_aminoacids urine_cometabolism 0.122 0.45 up no no no no no Fc gamma R-mediated phagocytosis Homovanillic acid+urine 0 0.503508772 0 kegg urine_cometabolism NA 0.45 no no no no no no GABAergic synapse Homovanillic acid+urine 0.477192982 0 0 kegg urine_cometabolism NA 0.45 no up up no no no Gastric cancer Homovanillic acid+urine 0 -0.507017544 -0.473076923 kegg urine_cometabolism NA 0.45 no no no no no no GCA+stool Homovanillic acid+urine 0 0 0.502579979 stool_bileacids urine_cometabolism 0.0809 0.45 no no no no no no GDCA+blood Homovanillic acid+urine 0 0 -0.461038961 serum_bileacids urine_cometabolism 0.632 0.45 no no no no no no Gemmiger Homovanillic acid+urine 0 0 -0.567124119 butyrate-producing Genus urine_cometabolism 0.595 0.45 no no no no no no GLCA+blood Homovanillic acid+urine 0 0 -0.507098955 serum_bileacids urine_cometabolism 0.319 0.45 no no no no no no Hypotaurine+blood Homovanillic acid+urine 0 0 -0.616883117 serum_aminoacids urine_cometabolism 0.933 0.45 no no no no no no Influenza A Homovanillic acid+urine -0.556140351 0 0 kegg urine_cometabolism NA 0.45 no no no no no no iso-LCA+blood Homovanillic acid+urine 0 0 -0.468140838 serum_bileacids urine_cometabolism 0.507 0.45 no no no no no no L-Glutamine+blood Homovanillic acid+urine -0.495098039 0 0 serum_aminoacids urine_cometabolism 0.639 0.45 no no no no no no L-Homocystine+blood Homovanillic acid+urine 0 0 -0.479220779 serum_aminoacids urine_cometabolism 0.197 0.45 no no no no no no L-Methionine+blood Homovanillic acid+urine 0 0 -0.433766234 serum_aminoacids urine_cometabolism 0.626 0.45 no no no no no no L-Phenylalanine+stool Homovanillic acid+urine 0 0.75 0 stool_cometabolism urine_cometabolism 0.398 0.45 no no no no no no L-Tryptophan+blood Homovanillic acid+urine 0 0 -0.511688312 serum_aminoacids urine_cometabolism 0.164 0.45 no no no no no no L-Tryptophan+stool Homovanillic acid+urine 0 0.7 0 stool_cometabolism urine_cometabolism 0.557 0.45 no no no no no no L-Tyrosine+blood Homovanillic acid+urine 0 0 -0.454545455 yes serum_aminoacids urine_cometabolism 0.00913 0.45 up up no no no no LCA+blood Homovanillic acid+urine 0 0 -0.564197877 serum_bileacids urine_cometabolism 0.884 0.45 no no no no no no Legionellosis Homovanillic acid+urine 0 0 0.456923077 kegg urine_cometabolism NA 0.45 no no no no no no Leishmaniasis Homovanillic acid+urine 0 0 0.466923077 kegg urine_cometabolism NA 0.45 no no no no no no Longevity regulating pathway - multiple species Homovanillic acid+urine 0.529824561 0 0 kegg urine_cometabolism NA 0.45 no no no no no no Lysosome Homovanillic acid+urine 0 0.496491228 0 kegg urine_cometabolism NA 0.45 no no no no no no MAPK signaling pathway Homovanillic acid+urine 0.471929825 0 0 kegg urine_cometabolism NA 0.45 no no no no no no MUFA%+blood Homovanillic acid+urine -0.536764706 0 0 serum_fattyacid urine_cometabolism 0.00142 0.45 up no dn no no no Non-small cell lung cancer Homovanillic acid+urine 0 0 -0.520769231 kegg urine_cometabolism NA 0.45 no no no no no no Odoribacter Homovanillic acid+urine 0 0 -0.438394057 butyrate-producing Genus urine_cometabolism 0.798 0.45 no no no no no no Olfactory transduction Homovanillic acid+urine 0 0.542105263 0 kegg urine_cometabolism NA 0.45 no no no no no no Oscillospira Homovanillic acid+urine -0.44962406 0 0 LPS-producing Genus urine_cometabolism 0.62 0.45 no no no no no no p53 signaling pathway Homovanillic acid+urine 0 -0.505263158 0 kegg urine_cometabolism NA 0.45 no no no no no no Peroxisome Homovanillic acid+urine 0.526315789 0 0 kegg urine_cometabolism NA 0.45 no no no no no no Phenylacetic acid+stool Homovanillic acid+urine -0.718681319 0 0 stool_cometabolism urine_cometabolism 0.785 0.45 no no no no no no Primary immunodeficiency Homovanillic acid+urine 0.494736842 0 0 kegg urine_cometabolism NA 0.45 no no no no no no Propionic acid+stool Homovanillic acid+urine 0.67032967 0 0 yes stool_scfa urine_cometabolism 0.0436 0.45 dn no up no no no PUFA/MUFA+blood Homovanillic acid+urine -0.558823529 0 0 serum_fattyacid urine_cometabolism 0.00108 0.45 dn no up no no no PUFA%+blood Homovanillic acid+urine -0.696078431 0 0 serum_fattyacid urine_cometabolism 0.0013 0.45 dn no up no no no Pyramidobacter Homovanillic acid+urine 0 0 -0.417838231 Genus urine_cometabolism 0.45 0.45 no no no no no no Serine+blood Homovanillic acid+urine -0.485294118 0 0 serum_aminoacids urine_cometabolism 0.942 0.45 no no no no no no SFA%+blood Homovanillic acid+urine -0.723039216 0 0 serum_fattyacid urine_cometabolism 0.0236 0.45 no up no no no no Signaling pathways regulating pluripotency of stem cells Homovanillic acid+urine 0 0 -0.443846154 kegg urine_cometabolism NA 0.45 no no no no no no Systemic lupus erythematosus Homovanillic acid+urine 0 0.456140351 0 kegg urine_cometabolism NA 0.45 no no no no no no total_stool_scfa+stool Homovanillic acid+urine 0.613186813 0 0 stool_scfa urine_cometabolism 0.0534 0.45 dn no up no no no Tuberculosis Homovanillic acid+urine 0 0.484210526 0 kegg urine_cometabolism NA 0.45 no no dn no no no TXB2+blood Homovanillic acid+urine 0 0.563544513 0 yes serum_ARA urine_cometabolism 0.0644 0.45 dn no no no no no UDCA+stool Homovanillic acid+urine 0 0 0.545923633 stool_bileacids urine_cometabolism 0.266 0.45 no no no no no no UFA%+blood Homovanillic acid+urine -0.600490196 0 0 serum_fattyacid urine_cometabolism 0.0236 0.45 no dn no no no no ABC transporters Human cytomegalovirus infection 0 -0.464426877 0 kegg kegg NA NA no up up no no dn Alcoholism Human cytomegalovirus infection 0.580869565 0.443675889 0.527927928 kegg kegg NA NA no no no no no dn Amino sugar and nucleotide sugar metabolism Human cytomegalovirus infection 0 -0.510869565 -0.532561133 kegg kegg NA NA no no no no no dn Aminoacyl-tRNA biosynthesis Human cytomegalovirus infection 0 -0.567193676 0 kegg kegg NA NA no no no no no dn Anaerostipes Human cytomegalovirus infection 0.427613883 0 0 butyrate-producing Genus kegg 0.568 NA no no no no no dn Antifolate resistance Human cytomegalovirus infection -0.662608696 -0.697628458 -0.516344916 kegg kegg NA NA no no no no no dn Antigen processing and presentation Human cytomegalovirus infection 0.933043478 0.93972332 0.879021879 kegg kegg NA NA no no no no no dn Apoptosis - multiple species Human cytomegalovirus infection 0 -0.518774704 -0.56010296 kegg kegg NA NA no no no no no dn Ascorbate and aldarate metabolism Human cytomegalovirus infection -0.416521739 0 -0.402059202 kegg kegg NA NA no no no no no dn Axon guidance Human cytomegalovirus infection 0.568695652 0.536561265 0.416988417 kegg kegg NA NA no up up no no dn Basal transcription factors Human cytomegalovirus infection 0 0 -0.428828829 kegg kegg NA NA no no no no no dn Base excision repair Human cytomegalovirus infection 0 -0.568181818 0 kegg kegg NA NA no no no no no dn Biosynthesis of cofactors Human cytomegalovirus infection 0 -0.489130435 0 kegg kegg NA NA no no no no no dn Carbohydrate digestion and absorption Human cytomegalovirus infection 0 0 -0.454311454 kegg kegg NA NA no no no no no dn Cell adhesion molecules Human cytomegalovirus infection 0.435652174 0.517786561 0.694723295 kegg kegg NA NA no no no no no dn Cell cycle Human cytomegalovirus infection 0 -0.536561265 0 kegg kegg NA NA no no no no no dn Cellular senescence Human cytomegalovirus infection 0.629565217 0.501976285 0.674131274 kegg kegg NA NA no no no no no dn Chagas disease Human cytomegalovirus infection 0 0 0.434749035 kegg kegg NA NA no no no no no dn Chemokine signaling pathway Human cytomegalovirus infection 0 0 0.45045045 kegg kegg NA NA no no no no no dn Cholesterol metabolism Human cytomegalovirus infection 0.510434783 0.518774704 0 yes kegg kegg NA NA no no up no no dn Complement and coagulation cascades Human cytomegalovirus infection 0 0 0.446589447 kegg kegg NA NA no no no no no dn Cortisol synthesis and secretion Human cytomegalovirus infection 0 -0.488142292 0 kegg kegg NA NA no no up no no dn Cushing syndrome Human cytomegalovirus infection 0 -0.496047431 0 kegg kegg NA NA no no up no no dn Cytosolic DNA-sensing pathway Human cytomegalovirus infection 0 0 0.493951094 kegg kegg NA NA no no no no no dn Desulfovibrio Human cytomegalovirus infection 0 0.422326513 0 Genus kegg 0.27 NA no no no no no dn Endocrine resistance Human cytomegalovirus infection -0.472173913 -0.576086957 0 kegg kegg NA NA no no no no no dn Endocytosis Human cytomegalovirus infection 0.564347826 0.54743083 0.694465894 kegg kegg NA NA no no no no no dn Epithelial cell signaling in Helicobacter pylori infection Human cytomegalovirus infection 0 0.427865613 0.629086229 kegg kegg NA NA no no no no no dn Fanconi anemia pathway Human cytomegalovirus infection 0 -0.683794466 -0.432175032 kegg kegg NA NA no no no no no dn FoxO signaling pathway Human cytomegalovirus infection 0 0 -0.475160875 kegg kegg NA NA no no no no no dn Fructose and mannose metabolism Human cytomegalovirus infection 0 -0.549407115 0 kegg kegg NA NA no no no no no dn Glycerolipid metabolism Human cytomegalovirus infection -0.439130435 -0.548418972 -0.428571429 kegg kegg NA NA no no up no no dn Glycerophospholipid metabolism Human cytomegalovirus infection -0.733043478 -0.616600791 -0.508880309 kegg kegg NA NA no no up no no dn "Glycine, serine and threonine metabolism" Human cytomegalovirus infection 0 -0.457509881 0 kegg kegg NA NA no up no no no dn Glycosphingolipid biosynthesis - ganglio series Human cytomegalovirus infection 0 0 -0.475418275 kegg kegg NA NA no no no no no dn Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Human cytomegalovirus infection -0.422608696 -0.567193676 0 kegg kegg NA NA no no no no no dn GnRH secretion Human cytomegalovirus infection 0 0 -0.44015444 kegg kegg NA NA no up up no no dn "Growth hormone synthesis, secretion and action" Human cytomegalovirus infection 0 -0.414031621 0 kegg kegg NA NA no no no no no dn Hedgehog signaling pathway Human cytomegalovirus infection -0.464347826 -0.697628458 -0.502187902 kegg kegg NA NA no no no no no dn Hepatitis C Human cytomegalovirus infection 0.416521739 0 0 kegg kegg NA NA no no no no no dn Histidine metabolism Human cytomegalovirus infection -0.423478261 0 0 kegg kegg NA NA no no no no no dn Homologous recombination Human cytomegalovirus infection 0 -0.571146245 -0.455083655 kegg kegg NA NA no no no no no dn IL-17 signaling pathway Human cytomegalovirus infection 0 0.420948617 0.461518662 kegg kegg NA NA no no no no no dn Inositol phosphate metabolism Human cytomegalovirus infection -0.603478261 -0.561264822 -0.691377091 kegg kegg NA NA no no no no no dn JAK-STAT signaling pathway Human cytomegalovirus infection 0 0 -0.436550837 kegg kegg NA NA no no no no no dn Leukocyte transendothelial migration Human cytomegalovirus infection 0 0.497035573 0 kegg kegg NA NA no no no no no dn Lysine degradation Human cytomegalovirus infection 0 -0.639328063 -0.476705277 kegg kegg NA NA no no no no no dn Lysosome Human cytomegalovirus infection 0 0.538537549 0 kegg kegg NA NA no no no no no dn Mannose type O-glycan biosynthesis Human cytomegalovirus infection 0 -0.466403162 0 kegg kegg NA NA no no no no no dn MAPK signaling pathway Human cytomegalovirus infection 0 -0.503952569 0 kegg kegg NA NA no no no no no dn Maturity onset diabetes of the young Human cytomegalovirus infection 0 -0.450592885 0 kegg kegg NA NA no up no no no dn Natural killer cell mediated cytotoxicity Human cytomegalovirus infection 0.635652174 0.559288538 0.725353925 kegg kegg NA NA no no no no no dn Neuroactive ligand-receptor interaction Human cytomegalovirus infection 0 0.550395257 0 kegg kegg NA NA up up up no no dn Neutrophil extracellular trap formation Human cytomegalovirus infection 0 0.428853755 0.467953668 kegg kegg NA NA no no no no no dn Nicotine addiction Human cytomegalovirus infection 0 -0.612648221 0 kegg kegg NA NA no up up no no dn Notch signaling pathway Human cytomegalovirus infection 0 -0.4743083 0 kegg kegg NA NA no no no no no dn Nucleotide excision repair Human cytomegalovirus infection 0 0 -0.42033462 kegg kegg NA NA no no no no no dn One carbon pool by folate Human cytomegalovirus infection -0.453043478 -0.572134387 -0.495752896 kegg kegg NA NA no no no no no dn Oscillospira Human cytomegalovirus infection 0 -0.416007905 0 LPS-producing Genus kegg 0.62 NA no no no no no dn Osteoclast differentiation Human cytomegalovirus infection 0 0 0.419047619 kegg kegg NA NA no no no no no dn Other types of O-glycan biosynthesis Human cytomegalovirus infection 0 -0.640316206 -0.565250965 kegg kegg NA NA no no no no no dn Ovarian steroidogenesis Human cytomegalovirus infection -0.426086957 0 0 kegg kegg NA NA no up up no no dn p53 signaling pathway Human cytomegalovirus infection 0 -0.445652174 -0.453796654 kegg kegg NA NA no no no no no dn Pathogenic Escherichia coli infection Human cytomegalovirus infection 0 0.494071146 0 kegg kegg NA NA no no no no no dn Pentose phosphate pathway Human cytomegalovirus infection 0 0.416996047 0 kegg kegg NA NA no no no no no dn Pertussis Human cytomegalovirus infection 0 0.444664032 0.491119691 kegg kegg NA NA no no dn no no dn Phagosome Human cytomegalovirus infection 0.423478261 0.537549407 0.605148005 kegg kegg NA NA no no no no no dn Phenylalanine metabolism Human cytomegalovirus infection 0 0 -0.475418275 kegg kegg NA NA no no no no no dn Phosphatidylinositol signaling system Human cytomegalovirus infection 0 0 -0.483140283 kegg kegg NA NA no no no no no dn Platinum drug resistance Human cytomegalovirus infection 0 -0.585968379 -0.595366795 kegg kegg NA NA no no no no no dn PPAR signaling pathway Human cytomegalovirus infection 0.487826087 0 0.602059202 kegg kegg NA NA no no no no no dn Progesterone-mediated oocyte maturation Human cytomegalovirus infection 0 -0.588932806 -0.411583012 kegg kegg NA NA no no no no no dn Purine metabolism Human cytomegalovirus infection 0 -0.475296443 0 kegg kegg NA NA no no no no no dn Regulation of actin cytoskeleton Human cytomegalovirus infection 0.474782609 0 0 kegg kegg NA NA no no no no no dn Renin-angiotensin system Human cytomegalovirus infection 0 0.528656126 0 kegg kegg NA NA no no no no no dn Retinol metabolism Human cytomegalovirus infection 0 -0.456521739 0 kegg kegg NA NA no no no no no dn Ribosome biogenesis in eukaryotes Human cytomegalovirus infection 0 -0.5256917 -0.409266409 kegg kegg NA NA no no no no no dn Salmonella infection Human cytomegalovirus infection 0 0.448616601 0 kegg kegg NA NA no no no no no dn Selenocompound metabolism Human cytomegalovirus infection -0.433913043 -0.694664032 -0.555984556 kegg kegg NA NA no no no no no dn Signaling pathways regulating pluripotency of stem cells Human cytomegalovirus infection 0 0 -0.463835264 kegg kegg NA NA no no no no no dn Sphingolipid signaling pathway Human cytomegalovirus infection 0 0.539525692 0 kegg kegg NA NA no no no no no dn Spliceosome Human cytomegalovirus infection 0 -0.486166008 0 kegg kegg NA NA no no no no no dn Staphylococcus aureus infection Human cytomegalovirus infection 0 0.489130435 0 kegg kegg NA NA up no no no no dn Steroid biosynthesis Human cytomegalovirus infection -0.410434783 0 0 kegg kegg NA NA no no no no no dn Taste transduction Human cytomegalovirus infection 0 -0.533596838 -0.610553411 kegg kegg NA NA no no up no no dn Taurine and hypotaurine metabolism Human cytomegalovirus infection -0.43826087 -0.543478261 -0.402316602 kegg kegg NA NA no no no no no dn Toll-like receptor signaling pathway Human cytomegalovirus infection 0 0 0.461776062 yes kegg kegg NA NA no no no no no dn Tuberculosis Human cytomegalovirus infection 0 0.46541502 0 kegg kegg NA NA no no dn no no dn Type I diabetes mellitus Human cytomegalovirus infection 0.42173913 0.52173913 0.685199485 kegg kegg NA NA no no no no no dn Ubiquinone and other terpenoid-quinone biosynthesis Human cytomegalovirus infection 0 -0.459486166 -0.401801802 kegg kegg NA NA no no no no no dn Viral protein interaction with cytokine and cytokine receptor Human cytomegalovirus infection 0.519130435 0 0.451222651 kegg kegg NA NA no no no no no dn Vitamin digestion and absorption Human cytomegalovirus infection -0.414782609 -0.455533597 0 kegg kegg NA NA no no no no no dn Yersinia infection Human cytomegalovirus infection 0 0.43972332 0 kegg kegg NA NA no no no no no dn ABC transporters Human immunodeficiency virus 1 infection 0 -0.48715415 0 kegg kegg NA NA no up up no no no Alcoholism Human immunodeficiency virus 1 infection 0.580869565 0 0.425482625 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Human immunodeficiency virus 1 infection 0 -0.505928854 -0.404118404 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Human immunodeficiency virus 1 infection 0 -0.509881423 0 kegg kegg NA NA no no no no no no Antifolate resistance Human immunodeficiency virus 1 infection -0.667826087 -0.688735178 -0.416216216 kegg kegg NA NA no no no no no no Antigen processing and presentation Human immunodeficiency virus 1 infection 0.931304348 0.958498024 0.895752896 kegg kegg NA NA no no no no no no Apoptosis - multiple species Human immunodeficiency virus 1 infection 0 -0.5256917 -0.508622909 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Human immunodeficiency virus 1 infection -0.409565217 0 0 kegg kegg NA NA no no no no no no Axon guidance Human immunodeficiency virus 1 infection 0.575652174 0.53458498 0 kegg kegg NA NA no up up no no no Base excision repair Human immunodeficiency virus 1 infection 0 -0.549407115 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Human immunodeficiency virus 1 infection 0 0 0.400514801 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Human immunodeficiency virus 1 infection 0 -0.476284585 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Human immunodeficiency virus 1 infection 0 0.515810277 0.655341055 kegg kegg NA NA no no no no no no Cell cycle Human immunodeficiency virus 1 infection 0 -0.495059289 0 kegg kegg NA NA no no no no no no Cellular senescence Human immunodeficiency virus 1 infection 0.573043478 0.480237154 0.65971686 kegg kegg NA NA no no no no no no Cholesterol metabolism Human immunodeficiency virus 1 infection 0.524347826 0.540513834 0 yes kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Human immunodeficiency virus 1 infection 0 -0.506916996 0 kegg kegg NA NA no no up no no no Cushing syndrome Human immunodeficiency virus 1 infection -0.419130435 -0.500988142 0 kegg kegg NA NA no no up no no no Cytosolic DNA-sensing pathway Human immunodeficiency virus 1 infection 0 0 0.423423423 kegg kegg NA NA no no no no no no Desulfovibrio Human immunodeficiency virus 1 infection 0 0.422326513 0 Genus kegg 0.27 NA no no no no no no Endocrine resistance Human immunodeficiency virus 1 infection -0.492173913 -0.605731225 -0.441956242 kegg kegg NA NA no no no no no no Endocytosis Human immunodeficiency virus 1 infection 0.508695652 0.535573123 0.691891892 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Human immunodeficiency virus 1 infection 0 0 0.561904762 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Human immunodeficiency virus 1 infection 0.979130435 0.990118577 0.971943372 kegg kegg NA NA no no no no no no Fanconi anemia pathway Human immunodeficiency virus 1 infection 0 -0.651185771 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Human immunodeficiency virus 1 infection 0 0 -0.432175032 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Human immunodeficiency virus 1 infection 0 -0.571146245 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Human immunodeficiency virus 1 infection -0.429565217 -0.578063241 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Human immunodeficiency virus 1 infection -0.668695652 -0.639328063 -0.420592021 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Human immunodeficiency virus 1 infection 0 -0.46541502 0 kegg kegg NA NA no up no no no no Glycosphingolipid biosynthesis - ganglio series Human immunodeficiency virus 1 infection 0 0 -0.428056628 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Human immunodeficiency virus 1 infection 0 -0.571146245 0 kegg kegg NA NA no no no no no no GnRH secretion Human immunodeficiency virus 1 infection 0 0 -0.406692407 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Human immunodeficiency virus 1 infection 0 -0.471343874 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Human immunodeficiency virus 1 infection -0.419130435 -0.663043478 -0.444787645 kegg kegg NA NA no no no no no no Hepatitis C Human immunodeficiency virus 1 infection 0.46173913 0 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Human immunodeficiency virus 1 infection 0.942608696 0.962450593 0.919176319 kegg kegg NA NA no no no no no no Homologous recombination Human immunodeficiency virus 1 infection 0 -0.559288538 0 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Human immunodeficiency virus 1 infection 0.983478261 0.995059289 0.967310167 kegg kegg NA NA no no dn no no no Human papillomavirus infection Human immunodeficiency virus 1 infection 0.473043478 0.424901186 0.5997426 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Human immunodeficiency virus 1 infection 0.952173913 0.98715415 0.934105534 kegg kegg NA NA no no no no no no IL-17 signaling pathway Human immunodeficiency virus 1 infection 0 0 0.458172458 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Human immunodeficiency virus 1 infection -0.577391304 -0.568181818 -0.61029601 kegg kegg NA NA no no no no no no Insulin secretion Human immunodeficiency virus 1 infection -0.436521739 0 0 yes kegg kegg NA NA no up up no no no Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection 0 0.518774704 0 kegg kegg NA NA no no dn no no no Leukocyte transendothelial migration Human immunodeficiency virus 1 infection 0 0.513833992 0 kegg kegg NA NA no no no no no no Lysine degradation Human immunodeficiency virus 1 infection 0 -0.619565217 -0.411840412 kegg kegg NA NA no no no no no no Lysosome Human immunodeficiency virus 1 infection 0 0.524703557 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Human immunodeficiency virus 1 infection 0 -0.447628458 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Human immunodeficiency virus 1 infection 0 -0.504940711 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Human immunodeficiency virus 1 infection 0 -0.422924901 0 kegg kegg NA NA no up no no no no Natural killer cell mediated cytotoxicity Human immunodeficiency virus 1 infection 0.56 0.542490119 0.736679537 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Human immunodeficiency virus 1 infection 0 0.526679842 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Human immunodeficiency virus 1 infection 0 0 0.451480051 kegg kegg NA NA no no no no no no Nicotine addiction Human immunodeficiency virus 1 infection 0 -0.638339921 0 kegg kegg NA NA no up up no no no Notch signaling pathway Human immunodeficiency virus 1 infection 0 -0.5 0 kegg kegg NA NA no no no no no no One carbon pool by folate Human immunodeficiency virus 1 infection -0.414782609 -0.529644269 -0.418018018 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Human immunodeficiency virus 1 infection 0 -0.643280632 -0.483397683 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Human immunodeficiency virus 1 infection -0.486956522 0 0 kegg kegg NA NA no up up no no no p53 signaling pathway Human immunodeficiency virus 1 infection 0 -0.471343874 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Human immunodeficiency virus 1 infection 0 0.475296443 0 kegg kegg NA NA no no no no no no Pertussis Human immunodeficiency virus 1 infection 0 0.420948617 0.443758044 kegg kegg NA NA no no dn no no no Phagosome Human immunodeficiency virus 1 infection 0 0.520750988 0.587129987 kegg kegg NA NA no no no no no no Phenylalanine metabolism Human immunodeficiency virus 1 infection 0 0 -0.474646075 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Human immunodeficiency virus 1 infection 0 0 -0.418018018 kegg kegg NA NA no no no no no no Phototransduction Human immunodeficiency virus 1 infection 0 0.433794466 0 kegg kegg NA NA no no no no no no Platinum drug resistance Human immunodeficiency virus 1 infection 0 -0.588932806 -0.537966538 kegg kegg NA NA no no no no no no PPAR signaling pathway Human immunodeficiency virus 1 infection 0.470434783 0 0.542857143 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Human immunodeficiency virus 1 infection 0 -0.583992095 0 kegg kegg NA NA no no no no no no Proteasome Human immunodeficiency virus 1 infection 0 0 0.505019305 kegg kegg NA NA no no no no no no Purine metabolism Human immunodeficiency virus 1 infection 0 -0.469367589 0 kegg kegg NA NA no no no no no no Ras signaling pathway Human immunodeficiency virus 1 infection 0.409565217 0 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Human immunodeficiency virus 1 infection 0.406956522 0 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Human immunodeficiency virus 1 infection 0 0.501976285 0 kegg kegg NA NA no no no no no no Retinol metabolism Human immunodeficiency virus 1 infection 0 -0.42687747 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Human immunodeficiency virus 1 infection 0 -0.479249012 0 kegg kegg NA NA no no no no no no Salmonella infection Human immunodeficiency virus 1 infection 0 0.461462451 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Human immunodeficiency virus 1 infection 0 -0.68083004 -0.42985843 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Human immunodeficiency virus 1 infection 0 0 -0.465637066 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Human immunodeficiency virus 1 infection 0 0.5256917 0 kegg kegg NA NA no no no no no no Spliceosome Human immunodeficiency virus 1 infection 0 -0.479249012 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Human immunodeficiency virus 1 infection 0 0.4743083 0 kegg kegg NA NA up no no no no no Taste transduction Human immunodeficiency virus 1 infection 0 -0.495059289 -0.53024453 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Human immunodeficiency virus 1 infection 0 -0.576086957 0 kegg kegg NA NA no no no no no no Tuberculosis Human immunodeficiency virus 1 infection 0 0.446640316 0 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Human immunodeficiency virus 1 infection 0 0.52173913 0.67001287 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Human immunodeficiency virus 1 infection 0.430434783 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Human immunodeficiency virus 1 infection 0 -0.45256917 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Human papillomavirus infection 0 -0.447628458 0 kegg kegg NA NA no no up no no no African trypanosomiasis Human papillomavirus infection 0 0.488142292 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Human papillomavirus infection 0 0.491106719 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Human papillomavirus infection 0 -0.576086957 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Human papillomavirus infection 0 0.435770751 0 kegg kegg NA NA no no no no no no Alzheimer disease Human papillomavirus infection -0.509565217 -0.438735178 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Human papillomavirus infection 0 0 -0.634749035 kegg kegg NA NA no no no no no no Amoebiasis Human papillomavirus infection 0.516521739 0.536561265 0 kegg kegg NA NA no no no no no no Amphetamine addiction Human papillomavirus infection -0.453043478 -0.723320158 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Human papillomavirus infection 0 -0.527667984 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Human papillomavirus infection -0.517391304 -0.450592885 0 kegg kegg NA NA no no no no no no Antifolate resistance Human papillomavirus infection 0 0 -0.436293436 kegg kegg NA NA no no no no no no Antigen processing and presentation Human papillomavirus infection 0.557391304 0 0.439382239 kegg kegg NA NA no no no no no no Apelin signaling pathway Human papillomavirus infection -0.450434783 -0.578063241 0 kegg kegg NA NA no no no no no no Apoptosis Human papillomavirus infection 0.53826087 0.814229249 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Human papillomavirus infection 0 0 -0.601544402 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Human papillomavirus infection -0.47826087 0 -0.501930502 kegg kegg NA NA no no no no no no Autophagy - animal Human papillomavirus infection 0 0.43972332 0 kegg kegg NA NA no no no no no no Autophagy - other Human papillomavirus infection -0.430434783 0 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Human papillomavirus infection 0 0.617588933 0 kegg kegg NA NA no no no no no no Basal transcription factors Human papillomavirus infection -0.666956522 -0.552371542 -0.498326898 kegg kegg NA NA no no no no no no Base excision repair Human papillomavirus infection 0 -0.458498024 -0.555727156 kegg kegg NA NA no no no no no no beta-Alanine metabolism Human papillomavirus infection 0 0 -0.430888031 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Human papillomavirus infection 0.64 0.554347826 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Human papillomavirus infection 0 -0.833992095 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Human papillomavirus infection 0 0 -0.43989704 kegg kegg NA NA no no no no no no Butanoate metabolism Human papillomavirus infection 0 -0.568181818 -0.476962677 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Human papillomavirus infection 0 0.692687747 0.401544402 kegg kegg NA NA no no no no no no cAMP signaling pathway Human papillomavirus infection 0 0.434782609 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Human papillomavirus infection 0 0.466403162 0 kegg kegg NA NA no no no no no no Carbon metabolism Human papillomavirus infection 0.451304348 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Human papillomavirus infection -0.440869565 0 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Human papillomavirus infection 0.896521739 0.862648221 0.815958816 kegg kegg NA NA no no no no no no Cell cycle Human papillomavirus infection -0.615652174 -0.597826087 0 kegg kegg NA NA no no no no no no Cellular senescence Human papillomavirus infection 0.960869565 0.982213439 0.950579151 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Human papillomavirus infection 0 0.508893281 0 kegg kegg NA NA no no no no no no Chagas disease Human papillomavirus infection 0 0.610671937 0.642213642 kegg kegg NA NA no no no no no no Chemokine signaling pathway Human papillomavirus infection 0 0.506916996 0.584298584 kegg kegg NA NA no no no no no no Cholesterol metabolism Human papillomavirus infection 0 0.485177866 0 yes kegg kegg NA NA no no up no no no Circadian entrainment Human papillomavirus infection 0 -0.531620553 0 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Human papillomavirus infection 0 -0.530632411 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Human papillomavirus infection 0.699130435 0.543478261 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Human papillomavirus infection 0 -0.432806324 0 kegg kegg NA NA no no up no no no Cushing syndrome Human papillomavirus infection 0 -0.520750988 0 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Human papillomavirus infection 0 -0.605731225 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Human papillomavirus infection 0 0.480237154 0.627541828 kegg kegg NA NA no no no no no no DNA replication Human papillomavirus infection -0.436521739 -0.56916996 -0.417245817 kegg kegg NA NA no no no no no no Dopaminergic synapse Human papillomavirus infection 0 -0.586956522 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Human papillomavirus infection 0 -0.533596838 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Human papillomavirus infection 0 -0.45256917 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Human papillomavirus infection 0 -0.485177866 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Human papillomavirus infection 0 -0.449604743 0 kegg kegg NA NA no no no no no no Endocytosis Human papillomavirus infection 0.95826087 0.880434783 0.926640927 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Human papillomavirus infection 0.48 0.678853755 0.691891892 kegg kegg NA NA no no no no no no Estrogen signaling pathway Human papillomavirus infection 0 -0.645256917 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Human papillomavirus infection -0.648695652 -0.662055336 -0.489317889 kegg kegg NA NA no no no no no no Fanconi anemia pathway Human papillomavirus infection -0.466086957 -0.486166008 -0.486743887 kegg kegg NA NA no no no no no no Fatty acid elongation Human papillomavirus infection 0 0 -0.405405405 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Human papillomavirus infection 0 0.736166008 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Human papillomavirus infection 0 0.498023715 0 kegg kegg NA NA no no no no no no Folate biosynthesis Human papillomavirus infection -0.415652174 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Human papillomavirus infection 0 0 -0.423423423 kegg kegg NA NA no no no no no no Galactose metabolism Human papillomavirus infection 0 0.455533597 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Human papillomavirus infection 0 -0.646245059 0 kegg kegg NA NA no no no no no no Glutathione metabolism Human papillomavirus infection 0 -0.643280632 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Human papillomavirus infection -0.566956522 0 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Human papillomavirus infection 0 -0.695652174 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Human papillomavirus infection 0.480869565 0.568181818 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Human papillomavirus infection 0 0.545454545 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Human papillomavirus infection -0.453043478 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Human papillomavirus infection 0 0.46541502 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Human papillomavirus infection 0 -0.59486166 0 kegg kegg NA NA no no no no no no GnRH secretion Human papillomavirus infection 0 0.415019763 0 kegg kegg NA NA no up up no no no GnRH signaling pathway Human papillomavirus infection 0 -0.42687747 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Human papillomavirus infection -0.471304348 0 0 kegg kegg NA NA no no no no no no Hepatitis B Human papillomavirus infection 0 0.479249012 0 kegg kegg NA NA no no no no no no Hepatitis C Human papillomavirus infection 0 0.505928854 0.411583012 kegg kegg NA NA no no no no no no Histidine metabolism Human papillomavirus infection 0 0 -0.452252252 kegg kegg NA NA no no no no no no Homologous recombination Human papillomavirus infection 0 0 -0.598198198 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Human papillomavirus infection 0.536521739 0.446640316 0.633204633 kegg kegg NA NA no no dn no no no Huntington disease Human papillomavirus infection -0.544347826 -0.431818182 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Human papillomavirus infection 0 0.540513834 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Human papillomavirus infection 0 -0.4743083 0 kegg kegg NA NA no no no no no no Influenza A Human papillomavirus infection 0.426086957 0.585968379 0 kegg kegg NA NA no no no no no no Insulin resistance Human papillomavirus infection 0 0.507905138 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Human papillomavirus infection -0.471304348 -0.556324111 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Human papillomavirus infection 0.584347826 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Human papillomavirus infection 0 -0.612648221 0 kegg kegg NA NA no no up no no no Lysosome Human papillomavirus infection 0 0.565217391 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Human papillomavirus infection 0 -0.544466403 0 kegg kegg NA NA no up no no no no Melanogenesis Human papillomavirus infection 0 -0.45256917 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Human papillomavirus infection 0 -0.468379447 0 kegg kegg NA NA no no no no no no Mismatch repair Human papillomavirus infection 0 -0.716403162 -0.433462033 kegg kegg NA NA no no no no no no Mitophagy - animal Human papillomavirus infection 0 -0.456521739 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Human papillomavirus infection -0.659130435 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Human papillomavirus infection 0 -0.496047431 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Human papillomavirus infection -0.431304348 -0.499011858 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Human papillomavirus infection 0.936521739 0.932806324 0.892406692 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Human papillomavirus infection 0 0.509881423 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Human papillomavirus infection 0 0.636363636 0.47953668 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Human papillomavirus infection 0.56173913 0.564229249 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Human papillomavirus infection 0 0.530632411 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Human papillomavirus infection 0 0.509881423 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Human papillomavirus infection 0.527826087 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Human papillomavirus infection 0 0.62944664 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Human papillomavirus infection -0.485217391 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Human papillomavirus infection 0 -0.432806324 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Human papillomavirus infection -0.465217391 -0.686758893 -0.638352638 kegg kegg NA NA no no no no no no One carbon pool by folate Human papillomavirus infection -0.486086957 -0.647233202 0 kegg kegg NA NA no no no no no no Oocyte meiosis Human papillomavirus infection -0.492173913 -0.506916996 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Human papillomavirus infection 0 0.668972332 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Human papillomavirus infection -0.619130435 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Human papillomavirus infection -0.488695652 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Human papillomavirus infection -0.487826087 0 -0.492406692 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Human papillomavirus infection 0 -0.455533597 0 kegg kegg NA NA no no no no no no Parkinson disease Human papillomavirus infection -0.406956522 -0.415019763 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Human papillomavirus infection 0.572173913 0.648221344 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Human papillomavirus infection -0.413913043 -0.446640316 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Human papillomavirus infection 0 -0.529644269 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Human papillomavirus infection 0.576521739 0.588932806 0 kegg kegg NA NA no no no no no no Pertussis Human papillomavirus infection 0.544347826 0.610671937 0 kegg kegg NA NA no no dn no no no Phagosome Human papillomavirus infection 0.886086957 0.795454545 0.675933076 kegg kegg NA NA no no no no no no Phenylalanine metabolism Human papillomavirus infection 0 -0.445652174 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Human papillomavirus infection -0.48 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Human papillomavirus infection 0 0.530632411 0 kegg kegg NA NA no up up no no no Platinum drug resistance Human papillomavirus infection 0 0 -0.595109395 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Human papillomavirus infection 0 -0.675889328 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Human papillomavirus infection 0 0.554347826 0.507593308 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Human papillomavirus infection 0 -0.414031621 -0.407722008 kegg kegg NA NA no no no no no no Prion disease Human papillomavirus infection -0.446956522 -0.460474308 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Human papillomavirus infection 0 0.647233202 0 kegg kegg NA NA no no no no no no Propanoate metabolism Human papillomavirus infection 0 -0.603754941 -0.430888031 kegg kegg NA NA no no no no no no Protein digestion and absorption Human papillomavirus infection 0 0.471343874 0 yes kegg kegg NA NA no up up no no no Protein export Human papillomavirus infection -0.639130435 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Human papillomavirus infection 0 -0.557312253 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Human papillomavirus infection 0 -0.610671937 -0.428571429 kegg kegg NA NA no no no no no no Purine metabolism Human papillomavirus infection 0 -0.621541502 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Human papillomavirus infection 0 -0.530632411 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Human papillomavirus infection 0 -0.674901186 -0.530759331 kegg kegg NA NA no no no no no no Rap1 signaling pathway Human papillomavirus infection 0.412173913 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Human papillomavirus infection 0 0.450592885 0 kegg kegg NA NA no no no no no no Renin secretion Human papillomavirus infection 0 -0.513833992 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Human papillomavirus infection 0 0.619565217 0 kegg kegg NA NA no no no no no no Retinol metabolism Human papillomavirus infection 0 -0.522727273 -0.543886744 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Human papillomavirus infection -0.413913043 -0.440711462 0 kegg kegg NA NA no no up no no no Ribosome Human papillomavirus infection -0.477391304 -0.456521739 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Human papillomavirus infection -0.554782609 -0.530632411 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Human papillomavirus infection 0 0.509881423 0 kegg kegg NA NA no no no no no no RNA degradation Human papillomavirus infection -0.63826087 -0.454545455 0 kegg kegg NA NA no no no no no no RNA polymerase Human papillomavirus infection -0.554782609 -0.596837945 -0.427541828 kegg kegg NA NA no no no no no no RNA transport Human papillomavirus infection 0 -0.429841897 0 kegg kegg NA NA no no no no no no Salmonella infection Human papillomavirus infection 0.42 0.496047431 0 kegg kegg NA NA no no no no no no Sarcina Human papillomavirus infection 0 0.444554224 0 Genus kegg 0.0703 NA no no no no no no Selenocompound metabolism Human papillomavirus infection -0.544347826 0 -0.514800515 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Human papillomavirus infection 0 0.695652174 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Human papillomavirus infection 0 0.557312253 0 kegg kegg NA NA up no no no no no Steroid biosynthesis Human papillomavirus infection -0.697391304 -0.583992095 -0.488803089 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Human papillomavirus infection 0 -0.644268775 -0.413642214 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Human papillomavirus infection 0 -0.693675889 -0.463063063 kegg kegg NA NA no no no no no no Taste transduction Human papillomavirus infection -0.487826087 -0.625494071 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Human papillomavirus infection -0.439130435 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Human papillomavirus infection -0.726956522 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Human papillomavirus infection -0.566956522 -0.43972332 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Human papillomavirus infection 0 0.526679842 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Human papillomavirus infection 0 0.528656126 0 kegg kegg NA NA no no no no no no Thermogenesis Human papillomavirus infection -0.526086957 -0.466403162 0 kegg kegg NA NA no no no no no no Thiamine metabolism Human papillomavirus infection 0 -0.795454545 0 kegg kegg NA NA no no no no no no TNF signaling pathway Human papillomavirus infection 0 0.62944664 0.576576577 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Human papillomavirus infection 0 0.650197628 0.662033462 yes kegg kegg NA NA no no no no no no Toxoplasmosis Human papillomavirus infection 0 0.42687747 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Human papillomavirus infection 0 0 -0.42007722 kegg kegg NA NA no up no no no no Tuberculosis Human papillomavirus infection 0 0.565217391 0 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Human papillomavirus infection 0.839130435 0.907114625 0.843500644 kegg kegg NA NA no no no no no no Tyrosine metabolism Human papillomavirus infection 0 -0.696640316 -0.514543115 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Human papillomavirus infection 0 -0.587944664 -0.52020592 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Human papillomavirus infection 0 -0.530632411 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Human papillomavirus infection 0 -0.583003953 -0.526126126 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Human papillomavirus infection 0 -0.421936759 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Human papillomavirus infection 0 -0.451581028 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Human papillomavirus infection 0 0.536561265 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Human papillomavirus infection 0.425217391 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Human papillomavirus infection -0.606086957 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Human papillomavirus infection -0.456521739 -0.436758893 0 kegg kegg NA NA no no no no no no Yersinia infection Human papillomavirus infection 0.464347826 0.639328063 0 kegg kegg NA NA no no no no no no ABC transporters Human T-cell leukemia virus 1 infection 0 -0.494071146 0 kegg kegg NA NA no up up no no no Alcoholism Human T-cell leukemia virus 1 infection 0.426086957 0 0.415186615 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Human T-cell leukemia virus 1 infection 0 -0.476284585 0 kegg kegg NA NA no no no no no no Amphetamine addiction Human T-cell leukemia virus 1 infection -0.411304348 0 0 kegg kegg NA NA no no no no no no Anaerostipes Human T-cell leukemia virus 1 infection 0.41184124 0 0 butyrate-producing Genus kegg 0.568 NA no no no no no no Antifolate resistance Human T-cell leukemia virus 1 infection -0.528695652 -0.65513834 -0.471814672 kegg kegg NA NA no no no no no no Antigen processing and presentation Human T-cell leukemia virus 1 infection 0.985217391 0.979249012 0.95984556 kegg kegg NA NA no no no no no no Apoptosis - multiple species Human T-cell leukemia virus 1 infection 0 -0.51284585 -0.421621622 kegg kegg NA NA no no no no no no Axon guidance Human T-cell leukemia virus 1 infection 0 0.502964427 0 kegg kegg NA NA no up up no no no Base excision repair Human T-cell leukemia virus 1 infection 0 -0.4743083 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Human T-cell leukemia virus 1 infection 0 0 -0.407722008 kegg kegg NA NA no no no no no no Cell adhesion molecules Human T-cell leukemia virus 1 infection 0.506086957 0.504940711 0.713513514 kegg kegg NA NA no no no no no no Cell cycle Human T-cell leukemia virus 1 infection 0 -0.415019763 0 kegg kegg NA NA no no no no no no Cellular senescence Human T-cell leukemia virus 1 infection 0.634782609 0.431818182 0.613642214 kegg kegg NA NA no no no no no no Cholesterol metabolism Human T-cell leukemia virus 1 infection 0.477391304 0.543478261 0 yes kegg kegg NA NA no no up no no no Cocaine addiction Human T-cell leukemia virus 1 infection 0 -0.425889328 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Human T-cell leukemia virus 1 infection 0 0 0.406949807 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Human T-cell leukemia virus 1 infection -0.475652174 -0.527667984 0 kegg kegg NA NA no no up no no no Cushing syndrome Human T-cell leukemia virus 1 infection -0.520869565 -0.496047431 0 kegg kegg NA NA no no up no no no Desulfovibrio Human T-cell leukemia virus 1 infection 0 0.444554224 0 Genus kegg 0.27 NA no no no no no no Drug metabolism - cytochrome P450 Human T-cell leukemia virus 1 infection 0.452173913 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Human T-cell leukemia virus 1 infection -0.623478261 -0.656126482 -0.409266409 kegg kegg NA NA no no no no no no Endocytosis Human T-cell leukemia virus 1 infection 0.60173913 0.508893281 0.633462033 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Human T-cell leukemia virus 1 infection 0 0 0.43011583 kegg kegg NA NA no no no no no no Ether lipid metabolism Human T-cell leukemia virus 1 infection -0.466956522 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Human T-cell leukemia virus 1 infection 0 -0.570158103 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Human T-cell leukemia virus 1 infection 0 -0.60770751 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Human T-cell leukemia virus 1 infection 0 -0.604743083 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Human T-cell leukemia virus 1 infection -0.728695652 -0.660079051 -0.446074646 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Human T-cell leukemia virus 1 infection 0 -0.422924901 0 kegg kegg NA NA no up no no no no Glycosphingolipid biosynthesis - ganglio series Human T-cell leukemia virus 1 infection 0 0 -0.434491634 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Human T-cell leukemia virus 1 infection 0 -0.554347826 -0.428056628 kegg kegg NA NA no no no no no no GnRH secretion Human T-cell leukemia virus 1 infection 0 0 -0.414414414 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Human T-cell leukemia virus 1 infection -0.479130435 -0.554347826 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Human T-cell leukemia virus 1 infection -0.583478261 -0.585968379 0 kegg kegg NA NA no no no no no no Homologous recombination Human T-cell leukemia virus 1 infection 0 -0.51284585 0 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Human T-cell leukemia virus 1 infection 0.956521739 0.972332016 0.920978121 kegg kegg NA NA no no dn no no no Human papillomavirus infection Human T-cell leukemia virus 1 infection 0.56 0 0.527413127 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Human T-cell leukemia virus 1 infection -0.502608696 -0.56027668 -0.566280566 kegg kegg NA NA no no no no no no Insulin secretion Human T-cell leukemia virus 1 infection -0.515652174 0 0 yes kegg kegg NA NA no up up no no no JAK-STAT signaling pathway Human T-cell leukemia virus 1 infection 0 0 -0.400514801 kegg kegg NA NA no no no no no no Leishmaniasis Human T-cell leukemia virus 1 infection 0.429565217 0.427865613 0.409009009 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Human T-cell leukemia virus 1 infection 0 0.502964427 0 kegg kegg NA NA no no no no no no Lysine degradation Human T-cell leukemia virus 1 infection 0 -0.580039526 0 kegg kegg NA NA no no no no no no Lysosome Human T-cell leukemia virus 1 infection 0 0.486166008 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Human T-cell leukemia virus 1 infection 0 -0.434782609 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Human T-cell leukemia virus 1 infection 0 -0.481225296 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Human T-cell leukemia virus 1 infection -0.415652174 -0.423913043 0 kegg kegg NA NA no up no no no no Metabolism of xenobiotics by cytochrome P450 Human T-cell leukemia virus 1 infection 0.427826087 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Human T-cell leukemia virus 1 infection 0.674782609 0.504940711 0.675418275 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Human T-cell leukemia virus 1 infection 0 0.484189723 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Human T-cell leukemia virus 1 infection 0 0 0.419047619 kegg kegg NA NA no no no no no no Nicotine addiction Human T-cell leukemia virus 1 infection 0 -0.631422925 0 kegg kegg NA NA no up up no no no Notch signaling pathway Human T-cell leukemia virus 1 infection 0 -0.54743083 0 kegg kegg NA NA no no no no no no One carbon pool by folate Human T-cell leukemia virus 1 infection 0 -0.447628458 0 kegg kegg NA NA no no no no no no Oscillospira Human T-cell leukemia virus 1 infection -0.417391304 0 0 LPS-producing Genus kegg 0.62 NA no no no no no no Other types of O-glycan biosynthesis Human T-cell leukemia virus 1 infection 0 -0.621541502 -0.44993565 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Human T-cell leukemia virus 1 infection -0.489565217 0 0 kegg kegg NA NA no up up no no no p53 signaling pathway Human T-cell leukemia virus 1 infection 0 -0.467391304 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Human T-cell leukemia virus 1 infection 0.42173913 0.435770751 0 kegg kegg NA NA no no no no no no Pertussis Human T-cell leukemia virus 1 infection 0.413913043 0 0.403603604 kegg kegg NA NA no no dn no no no Phagosome Human T-cell leukemia virus 1 infection 0.471304348 0.488142292 0.596911197 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Human T-cell leukemia virus 1 infection 0 0 -0.409266409 kegg kegg NA NA no no no no no no Phototransduction Human T-cell leukemia virus 1 infection 0 0.501976285 0 kegg kegg NA NA no no no no no no Platinum drug resistance Human T-cell leukemia virus 1 infection 0 -0.564229249 -0.445045045 kegg kegg NA NA no no no no no no PPAR signaling pathway Human T-cell leukemia virus 1 infection 0.497391304 0 0.422136422 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Human T-cell leukemia virus 1 infection 0 -0.544466403 0 kegg kegg NA NA no no no no no no Proteasome Human T-cell leukemia virus 1 infection 0 0.418972332 0.458172458 kegg kegg NA NA no no no no no no Purine metabolism Human T-cell leukemia virus 1 infection 0 -0.444664032 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Human T-cell leukemia virus 1 infection 0.514782609 0 0.44041184 kegg kegg NA NA no no no no no no Renin-angiotensin system Human T-cell leukemia virus 1 infection 0 0.448616601 0 kegg kegg NA NA no no no no no no Salmonella infection Human T-cell leukemia virus 1 infection 0.502608696 0.469367589 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Human T-cell leukemia virus 1 infection 0 -0.632411067 -0.403603604 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection 0 0 -0.442471042 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Human T-cell leukemia virus 1 infection 0 0.484189723 0 kegg kegg NA NA no no no no no no Spliceosome Human T-cell leukemia virus 1 infection 0 -0.431818182 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Human T-cell leukemia virus 1 infection 0 0.453557312 0.435521236 kegg kegg NA NA up no no no no no Steroid biosynthesis Human T-cell leukemia virus 1 infection -0.430434783 0 0 kegg kegg NA NA no no no no no no Taste transduction Human T-cell leukemia virus 1 infection 0 0 -0.488288288 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Human T-cell leukemia virus 1 infection -0.495652174 -0.609683794 -0.457400257 kegg kegg NA NA no no no no no no Tuberculosis Human T-cell leukemia virus 1 infection 0 0.418972332 0 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Human T-cell leukemia virus 1 infection 0.471304348 0.507905138 0.717631918 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Human T-cell leukemia virus 1 infection -0.482608696 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Human T-cell leukemia virus 1 infection -0.55826087 -0.41798419 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Huntington disease -0.542608696 0 0 kegg kegg NA NA no no no no no no Adherens junction Huntington disease 0 0.662055336 0.561647362 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Huntington disease 0.706956522 0.820158103 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Huntington disease 0 -0.831027668 -0.517631918 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Huntington disease -0.49826087 -0.767786561 -0.48957529 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Huntington disease 0.586086957 0.780632411 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Huntington disease 0 0 -0.441184041 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Huntington disease -0.646956522 -0.75 0 kegg kegg NA NA no no no no no no Alzheimer disease Huntington disease 0.982608696 0.994071146 0.942084942 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Huntington disease -0.64 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Huntington disease -0.596521739 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Huntington disease 0 0.461462451 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Huntington disease 0.976521739 0.981225296 0.968597169 kegg kegg NA NA no no no no no no Apelin signaling pathway Huntington disease 0 0.742094862 0 kegg kegg NA NA no no no no no no Apoptosis Huntington disease -0.492173913 -0.58201581 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Huntington disease 0 -0.429841897 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Huntington disease 0 -0.791501976 -0.588159588 kegg kegg NA NA no up no no no no Arginine biosynthesis Huntington disease -0.529565217 -0.716403162 -0.436808237 kegg kegg NA NA no no no no no no Autophagy - animal Huntington disease 0 -0.71541502 -0.513513514 kegg kegg NA NA no no no no no no Axon guidance Huntington disease 0.504347826 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Huntington disease 0 -0.627470356 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Huntington disease -0.731304348 0 0 kegg kegg NA NA no no no no no no Bile secretion Huntington disease 0.414782609 0.51284585 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Huntington disease -0.826086957 -0.661067194 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Huntington disease -0.430434783 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Huntington disease -0.58 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Huntington disease 0 -0.631422925 -0.435521236 kegg kegg NA NA no no no no no no Calcium signaling pathway Huntington disease 0.71826087 0.744071146 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Huntington disease 0.755652174 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Huntington disease 0 -0.489130435 0 kegg kegg NA NA no no no no no no Carbon metabolism Huntington disease -0.777391304 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Huntington disease 0.960869565 0.967391304 0.928957529 kegg kegg NA NA no no up no no no Cell adhesion molecules Huntington disease -0.58 -0.450592885 0 kegg kegg NA NA no no no no no no Cellular senescence Huntington disease 0 -0.438735178 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Huntington disease 0 -0.662055336 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Huntington disease 0 -0.466403162 0 kegg kegg NA NA no no no no no no Cholinergic synapse Huntington disease 0 -0.440711462 0 kegg kegg NA NA no no no no no no Circadian entrainment Huntington disease 0 0.589920949 0 kegg kegg NA NA no up up no no no Circadian rhythm Huntington disease 0.669565217 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Huntington disease 0 0.41798419 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Huntington disease -0.606956522 -0.651185771 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Huntington disease 0 0.43083004 0 kegg kegg NA NA no no up no no no Cushing syndrome Huntington disease 0.445217391 0.48715415 0 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Huntington disease 0 0.455533597 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Huntington disease 0 -0.449604743 0 kegg kegg NA NA no no no no no no DNA replication Huntington disease 0 0.443675889 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Huntington disease 0.640869565 0.723320158 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Huntington disease 0 0.505928854 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Huntington disease -0.603478261 0.566205534 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Huntington disease 0 0.661067194 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Huntington disease 0.50173913 0.811264822 0 kegg kegg NA NA no no no no no no Endocrine resistance Huntington disease 0.419130435 0 0 kegg kegg NA NA no no no no no no Endocytosis Huntington disease -0.512173913 -0.48715415 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Huntington disease 0 -0.450592885 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Huntington disease 0.72 0.471343874 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Huntington disease -0.536521739 -0.632411067 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Huntington disease -0.42173913 -0.812252964 -0.604890605 kegg kegg NA NA no no no no no no Fatty acid degradation Huntington disease -0.647826087 -0.853754941 0 kegg kegg NA NA no no no no no no Fatty acid elongation Huntington disease -0.533913043 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Huntington disease -0.750434783 -0.830039526 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Huntington disease 0 -0.718379447 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Huntington disease -0.503478261 -0.677865613 -0.403346203 kegg kegg NA NA no no no no no no Focal adhesion Huntington disease 0 0.520750988 0.440926641 kegg kegg NA NA no up up no no no Folate biosynthesis Huntington disease 0 0.431818182 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Huntington disease 0 -0.759881423 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Huntington disease -0.755652174 -0.567193676 -0.483912484 kegg kegg NA NA no no no no no no GABAergic synapse Huntington disease 0 -0.640316206 0 kegg kegg NA NA no up up no no no Galactose metabolism Huntington disease -0.752173913 -0.781620553 0 kegg kegg NA NA no no no no no no Gastric acid secretion Huntington disease 0 0.730237154 0.538481338 kegg kegg NA NA no no no no no no Glucagon signaling pathway Huntington disease 0 0.778656126 0 kegg kegg NA NA no no no no no no Glutathione metabolism Huntington disease 0 0.706521739 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Huntington disease 0 -0.608695652 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Huntington disease -0.667826087 0.425889328 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Huntington disease 0 -0.734189723 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Huntington disease 0.557391304 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Huntington disease 0 -0.416007905 0 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Huntington disease -0.636521739 -0.727272727 -0.501930502 kegg kegg NA NA no no no no no no GnRH secretion Huntington disease 0 -0.419960474 0 kegg kegg NA NA no up up no no no GnRH signaling pathway Huntington disease 0 0.503952569 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Huntington disease 0.526086957 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Huntington disease 0 0.627470356 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Huntington disease 0 0.638339921 0.566280566 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Huntington disease 0 -0.746047431 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Huntington disease 0 -0.558300395 -0.465122265 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Huntington disease 0.519130435 0.814229249 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Huntington disease 0 -0.459486166 0 kegg kegg NA NA no no no no no no Insulin resistance Huntington disease 0.417391304 -0.541501976 0 kegg kegg NA NA no no no no no no Insulin secretion Huntington disease 0 0.54743083 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Huntington disease 0 0.675889328 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Huntington disease 0 -0.741106719 0 kegg kegg NA NA no no no no no no Long-term depression Huntington disease 0.552173913 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Huntington disease 0.510434783 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Huntington disease 0 -0.690711462 0 kegg kegg NA NA no no no no no no Melanogenesis Huntington disease 0.487826087 0.845849802 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Huntington disease 0 0.455533597 0 kegg kegg NA NA no no no no no no Mineral absorption Huntington disease 0.410434783 0.624505929 0 kegg kegg NA NA no no no no no no Mitophagy - animal Huntington disease 0.535652174 0.827075099 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Huntington disease 0.760869565 0.657114625 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Huntington disease 0 0.653162055 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Huntington disease 0 -0.441699605 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Huntington disease 0 0.568181818 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Huntington disease -0.512173913 -0.429841897 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Huntington disease 0 -0.533596838 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Huntington disease 0.54 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Huntington disease -0.525217391 -0.550395257 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Huntington disease 0 -0.717391304 -0.496267696 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Huntington disease -0.446956522 -0.756916996 -0.488030888 kegg kegg NA NA no no no no no no Nitrogen metabolism Huntington disease -0.468695652 -0.619565217 -0.4002574 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Huntington disease 0 -0.778656126 -0.465894466 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Huntington disease 0.972173913 0.96541502 0.885456885 kegg kegg NA NA no no no no no no Non-homologous end-joining Huntington disease -0.648695652 0 0 kegg kegg NA NA no no no no no no Olfactory transduction Huntington disease 0 -0.615612648 0 kegg kegg NA NA no no no no no no Oocyte meiosis Huntington disease 0.44 0.43083004 0 kegg kegg NA NA no no no no no no Oscillospira Huntington disease 0 -0.477272727 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Huntington disease 0 -0.749011858 -0.46048906 kegg kegg NA NA no no no no no no Other glycan degradation Huntington disease 0 -0.495059289 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Huntington disease 0.977391304 0.990118577 0.958558559 kegg kegg NA NA no no no no no no Pancreatic secretion Huntington disease 0.648695652 0.73715415 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Huntington disease 0 -0.799407115 -0.447876448 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Huntington disease 0.669565217 0.799407115 0 kegg kegg NA NA no no no no no no Parkinson disease Huntington disease 0.84 0.967391304 0.503217503 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Huntington disease 0 0.535573123 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Huntington disease -0.544347826 -0.580039526 -0.417503218 kegg kegg NA NA no no no no no no Peroxisome Huntington disease -0.580869565 -0.73715415 0 kegg kegg NA NA no no no no no no Phagosome Huntington disease -0.616521739 -0.463438735 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Huntington disease 0.576521739 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Huntington disease 0 -0.523715415 0 kegg kegg NA NA no up up no no no Phototransduction Huntington disease 0 0.506916996 0.455855856 kegg kegg NA NA no no no no no no Platelet activation Huntington disease 0 0.543478261 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Huntington disease 0 0.416996047 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Huntington disease 0 -0.616600791 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Huntington disease 0 -0.649209486 -0.535135135 kegg kegg NA NA no no no no no no Propanoate metabolism Huntington disease 0 0.42687747 0 kegg kegg NA NA no no no no no no Proteasome Huntington disease 0 0.482213439 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Huntington disease -0.650434783 -0.852766798 -0.505791506 yes kegg kegg NA NA no up up no no no Protein export Huntington disease 0.574782609 0.765810277 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Huntington disease 0 0.64229249 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Huntington disease 0 0.482213439 0 kegg kegg NA NA no no no no no no Purine metabolism Huntington disease 0 0.448616601 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Huntington disease -0.720869565 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Huntington disease 0 0.562252964 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Huntington disease 0 0.433794466 0 kegg kegg NA NA no no no no no no Ras signaling pathway Huntington disease 0 0.500988142 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Huntington disease 0 0 0.437580438 kegg kegg NA NA no no no no no no Relaxin signaling pathway Huntington disease 0.551304348 0 0 kegg kegg NA NA no no no no no no Renin secretion Huntington disease 0 0.825098814 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Huntington disease 0 -0.615612648 0 kegg kegg NA NA no no no no no no Retinol metabolism Huntington disease -0.524347826 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Huntington disease 0.812173913 0.921936759 0.753153153 kegg kegg NA NA no no up no no no Ribosome Huntington disease 0.726086957 0.87055336 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Huntington disease 0 -0.678853755 -0.472844273 kegg kegg NA NA no no no no no no RNA degradation Huntington disease 0.713913043 0.669960474 0 kegg kegg NA NA no no no no no no RNA polymerase Huntington disease 0 0.558300395 0 kegg kegg NA NA no no no no no no RNA transport Huntington disease 0 0.543478261 0 kegg kegg NA NA no no no no no no Ruminococcus Huntington disease 0 0.417039417 0 Genus kegg 0.0679 NA no no dn no no no Signaling pathways regulating pluripotency of stem cells Huntington disease 0.595652174 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Huntington disease 0 -0.66798419 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Huntington disease -0.507826087 -0.822134387 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Huntington disease 0 0 0.414414414 kegg kegg NA NA no no no no no no Sulfur metabolism Huntington disease -0.460869565 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Huntington disease 0 -0.574110672 0 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Huntington disease 0 -0.508893281 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Huntington disease 0.727826087 0.660079051 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Huntington disease 0 -0.421936759 0 kegg kegg NA NA no no no no no no Thermogenesis Huntington disease 0.954782609 0.982213439 0.928442728 kegg kegg NA NA no no no no no no Thiamine metabolism Huntington disease 0 0.419960474 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Huntington disease 0 0.643280632 0.494208494 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Huntington disease 0 0.636363636 0 kegg kegg NA NA no no no no no no Tight junction Huntington disease 0 0.527667984 0 kegg kegg NA NA no no no no no no TNF signaling pathway Huntington disease 0 -0.552371542 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Huntington disease 0 -0.657114625 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Huntington disease -0.547826087 0 0 kegg kegg NA NA no up no no no no Type I diabetes mellitus Huntington disease -0.474782609 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Huntington disease 0 -0.624505929 -0.497554698 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Huntington disease 0.548695652 0.846837945 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Huntington disease -0.454782609 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Huntington disease 0.686086957 0.860671937 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Huntington disease 0.53826087 0.778656126 0.414414414 kegg kegg NA NA no no no no no no VEGF signaling pathway Huntington disease 0 -0.444664032 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Huntington disease 0.656521739 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Huntington disease 0.720869565 0.647233202 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Hypertrophic cardiomyopathy 0.453913043 0.504940711 0 kegg kegg NA NA no no no no up up ABC transporters Hypertrophic cardiomyopathy 0 -0.496047431 0 kegg kegg NA NA no up up no up up Adherens junction Hypertrophic cardiomyopathy 0.89826087 0.947628458 0.957014157 kegg kegg NA NA no no no no up up Adipocytokine signaling pathway Hypertrophic cardiomyopathy 0 -0.618577075 0 kegg kegg NA NA no no no no up up AGE-RAGE signaling pathway in diabetic complications Hypertrophic cardiomyopathy 0 -0.54743083 0 kegg kegg NA NA no no no no up up "Alanine, aspartate and glutamate metabolism" Hypertrophic cardiomyopathy 0 -0.649209486 0 kegg kegg NA NA no no no no up up Allograft rejection Hypertrophic cardiomyopathy 0.468695652 0 0 kegg kegg NA NA no no no no up up alpha-Linolenic acid metabolism Hypertrophic cardiomyopathy 0.42 0 0 kegg kegg NA NA no no no no up up Alzheimer disease Hypertrophic cardiomyopathy 0 0.545454545 0.400772201 kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis Hypertrophic cardiomyopathy 0 0.565217391 0.56010296 kegg kegg NA NA no no no no up up Apelin signaling pathway Hypertrophic cardiomyopathy -0.506956522 0 0 kegg kegg NA NA no no no no up up Apoptosis Hypertrophic cardiomyopathy 0.584347826 0 0.451737452 kegg kegg NA NA no no no no up up Apoptosis - multiple species Hypertrophic cardiomyopathy -0.583478261 -0.555335968 0 kegg kegg NA NA no no no no up up Arginine and proline metabolism Hypertrophic cardiomyopathy 0 -0.564229249 0 kegg kegg NA NA no up no no up up Arginine biosynthesis Hypertrophic cardiomyopathy 0 -0.583003953 0 kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism Hypertrophic cardiomyopathy 0 0.436758893 0 kegg kegg NA NA no no no no up up Asthma Hypertrophic cardiomyopathy 0 0.511857708 0 kegg kegg NA NA no no no no up up Autoimmune thyroid disease Hypertrophic cardiomyopathy 0.468695652 0 0 kegg kegg NA NA no no no no up up Autophagy - animal Hypertrophic cardiomyopathy -0.729565217 -0.860671937 -0.525868726 kegg kegg NA NA no no no no up up Autophagy - other Hypertrophic cardiomyopathy -0.894782609 -0.793478261 -0.526126126 kegg kegg NA NA no no no no up up B cell receptor signaling pathway Hypertrophic cardiomyopathy 0 -0.51284585 0 kegg kegg NA NA no no no no up up Bacterial invasion of epithelial cells Hypertrophic cardiomyopathy 0.917391304 0.896245059 0.930501931 kegg kegg NA NA no no no no up up Basal transcription factors Hypertrophic cardiomyopathy -0.746956522 0 0 kegg kegg NA NA no no no no up up Base excision repair Hypertrophic cardiomyopathy -0.531304348 0 0 kegg kegg NA NA no no no no up up beta-Alanine metabolism Hypertrophic cardiomyopathy 0.507826087 0.443675889 0 kegg kegg NA NA no no no no up up Bifidobacterium Hypertrophic cardiomyopathy 0 0.445271301 0 acetate-producing Genus kegg 0.105 NA no dn no no up up Bile secretion Hypertrophic cardiomyopathy 0 0.418972332 0 kegg kegg NA NA no no no no up up Biosynthesis of amino acids Hypertrophic cardiomyopathy 0.455652174 0 0 kegg kegg NA NA no no no no up up Biosynthesis of cofactors Hypertrophic cardiomyopathy 0.430434783 0 0 kegg kegg NA NA no no no no up up Bladder cancer Hypertrophic cardiomyopathy 0 -0.540513834 0 kegg kegg NA NA no no no no up up Breast cancer Hypertrophic cardiomyopathy -0.450434783 -0.681818182 0 kegg kegg NA NA no no no no up up Butanoate metabolism Hypertrophic cardiomyopathy 0 0.498023715 0 kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway Hypertrophic cardiomyopathy -0.540869565 -0.617588933 -0.548519949 kegg kegg NA NA no no no no up up Calcium signaling pathway Hypertrophic cardiomyopathy 0 0.414031621 0 kegg kegg NA NA no up up no up up Carbohydrate digestion and absorption Hypertrophic cardiomyopathy -0.506086957 -0.429841897 0 kegg kegg NA NA no no no no up up Carbon metabolism Hypertrophic cardiomyopathy 0.511304348 0.450592885 0 kegg kegg NA NA no no no no up up Cardiac muscle contraction Hypertrophic cardiomyopathy 0 0.574110672 0.505791506 kegg kegg NA NA no no up no up up Cell adhesion molecules Hypertrophic cardiomyopathy 0.516521739 0 0 kegg kegg NA NA no no no no up up Cell cycle Hypertrophic cardiomyopathy -0.432173913 0 0 kegg kegg NA NA no no no no up up Chagas disease Hypertrophic cardiomyopathy 0 -0.567193676 0 kegg kegg NA NA no no no no up up Choline metabolism in cancer Hypertrophic cardiomyopathy -0.535652174 -0.53458498 0 kegg kegg NA NA no no no no up up Cholinergic synapse Hypertrophic cardiomyopathy -0.467826087 0 0 kegg kegg NA NA no no no no up up Chronic myeloid leukemia Hypertrophic cardiomyopathy -0.42173913 -0.545454545 -0.531274131 kegg kegg NA NA no no no no up up Circadian entrainment Hypertrophic cardiomyopathy 0 0.658102767 0 kegg kegg NA NA no up up no up up Circadian rhythm Hypertrophic cardiomyopathy -0.705217391 0 -0.415186615 kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) Hypertrophic cardiomyopathy 0 0.495059289 0 kegg kegg NA NA no no no no up up Complement and coagulation cascades Hypertrophic cardiomyopathy 0 0 0.420592021 kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Hypertrophic cardiomyopathy -0.430434783 0.416996047 0 kegg kegg NA NA no no no no up up Cytokine-cytokine receptor interaction Hypertrophic cardiomyopathy 0 0 0.703989704 kegg kegg NA NA no no no no up up Cytosolic DNA-sensing pathway Hypertrophic cardiomyopathy 0 -0.45256917 0 kegg kegg NA NA no no no no up up Dopaminergic synapse Hypertrophic cardiomyopathy 0 0.510869565 0 kegg kegg NA NA no up no no up up Drug metabolism - cytochrome P450 Hypertrophic cardiomyopathy 0 0.637351779 0 kegg kegg NA NA no no no no up up Drug metabolism - other enzymes Hypertrophic cardiomyopathy 0 0.727272727 0 kegg kegg NA NA no no no no up up EGFR tyrosine kinase inhibitor resistance Hypertrophic cardiomyopathy -0.483478261 0 0 kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Hypertrophic cardiomyopathy 0 0.467391304 0 kegg kegg NA NA no no no no up up Endometrial cancer Hypertrophic cardiomyopathy 0 -0.599802372 -0.412355212 kegg kegg NA NA no no no no up up ErbB signaling pathway Hypertrophic cardiomyopathy -0.448695652 -0.511857708 0 kegg kegg NA NA no no no no up up Estrogen signaling pathway Hypertrophic cardiomyopathy 0 0.453557312 0 kegg kegg NA NA no no no no up up Fatty acid biosynthesis Hypertrophic cardiomyopathy 0 -0.556324111 0 kegg kegg NA NA no no no no up up Fatty acid degradation Hypertrophic cardiomyopathy 0 -0.526679842 0 kegg kegg NA NA no no no no up up Fatty acid metabolism Hypertrophic cardiomyopathy 0 -0.466403162 0 kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway Hypertrophic cardiomyopathy 0 -0.467391304 0 kegg kegg NA NA no no no no up up Focal adhesion Hypertrophic cardiomyopathy 0.89826087 0.955533597 0.913256113 kegg kegg NA NA no up up no up up FoxO signaling pathway Hypertrophic cardiomyopathy 0 -0.679841897 0 kegg kegg NA NA no no no no up up Fructose and mannose metabolism Hypertrophic cardiomyopathy 0.439130435 0 0 kegg kegg NA NA no no no no up up GABAergic synapse Hypertrophic cardiomyopathy 0 -0.467391304 0 kegg kegg NA NA no up up no up up Galactose metabolism Hypertrophic cardiomyopathy 0.510434783 0 0 kegg kegg NA NA no no no no up up Gap junction Hypertrophic cardiomyopathy 0.419130435 0 0 kegg kegg NA NA no no no no up up Gastric acid secretion Hypertrophic cardiomyopathy 0.844347826 0.932806324 0.898584299 kegg kegg NA NA no no no no up up Glioma Hypertrophic cardiomyopathy -0.543478261 0 0 kegg kegg NA NA no no no no up up Glutathione metabolism Hypertrophic cardiomyopathy 0 0.434782609 0 kegg kegg NA NA no no no no up up Glycerolipid metabolism Hypertrophic cardiomyopathy 0 -0.514822134 0 kegg kegg NA NA no no up no up up Glycerophospholipid metabolism Hypertrophic cardiomyopathy -0.489565217 -0.56916996 0 kegg kegg NA NA no no up no up up Glycolysis / Gluconeogenesis Hypertrophic cardiomyopathy 0.413043478 0.579051383 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Hypertrophic cardiomyopathy 0 -0.606719368 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Hypertrophic cardiomyopathy 0.593043478 0 0 kegg kegg NA NA no no no no up up Glyoxylate and dicarboxylate metabolism Hypertrophic cardiomyopathy 0 -0.59486166 0 kegg kegg NA NA no no no no up up GnRH secretion Hypertrophic cardiomyopathy -0.450434783 -0.514822134 0 kegg kegg NA NA no up up no up up Graft-versus-host disease Hypertrophic cardiomyopathy 0.468695652 0 0 kegg kegg NA NA no no no no up up Hematopoietic cell lineage Hypertrophic cardiomyopathy 0 0.436758893 0.514285714 kegg kegg NA NA no no no no up up Hepatitis B Hypertrophic cardiomyopathy -0.588695652 -0.808300395 -0.498326898 kegg kegg NA NA no no no no up up Hepatitis C Hypertrophic cardiomyopathy 0 -0.570158103 -0.428571429 kegg kegg NA NA no no no no up up Hepatocellular carcinoma Hypertrophic cardiomyopathy 0.850434783 0.927865613 0.896010296 kegg kegg NA NA no no no no up up HIF-1 signaling pathway Hypertrophic cardiomyopathy -0.54 0 0 kegg kegg NA NA no no no no up up Hippo signaling pathway Hypertrophic cardiomyopathy 0.837391304 0.907114625 0.927413127 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Hypertrophic cardiomyopathy 0 -0.510869565 0 kegg kegg NA NA no no no no up up Homologous recombination Hypertrophic cardiomyopathy 0 -0.41798419 0 kegg kegg NA NA no no no no up up Human papillomavirus infection Hypertrophic cardiomyopathy 0.419130435 0 0 kegg kegg NA NA no no no no up up Huntington disease Hypertrophic cardiomyopathy 0 0.550395257 0.484427284 kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels Hypertrophic cardiomyopathy 0 0.501976285 0 kegg kegg NA NA no no no no up up Influenza A Hypertrophic cardiomyopathy 0.574782609 0 0.686486486 kegg kegg NA NA no no no no up up Inositol phosphate metabolism Hypertrophic cardiomyopathy 0 -0.5 0 kegg kegg NA NA no no no no up up Insulin resistance Hypertrophic cardiomyopathy -0.71826087 -0.679841897 -0.643758044 kegg kegg NA NA no no no no up up Insulin signaling pathway Hypertrophic cardiomyopathy -0.569565217 0 0 kegg kegg NA NA no no no no up up JAK-STAT signaling pathway Hypertrophic cardiomyopathy 0 -0.681818182 0 kegg kegg NA NA no no no no up up Lachnospira Hypertrophic cardiomyopathy 0 0.573264164 0 butyrate-producing Genus kegg 0.279 NA no no no no up up Leukocyte transendothelial migration Hypertrophic cardiomyopathy 0.751304348 0.650197628 0.739253539 kegg kegg NA NA no no no no up up Linoleic acid metabolism Hypertrophic cardiomyopathy 0 0.419960474 0 kegg kegg NA NA no no no no up up Long-term potentiation Hypertrophic cardiomyopathy -0.569565217 0 0 kegg kegg NA NA no no up no up up Longevity regulating pathway Hypertrophic cardiomyopathy 0 -0.505928854 0 kegg kegg NA NA no no no no up up Lysine degradation Hypertrophic cardiomyopathy -0.452173913 0 0 kegg kegg NA NA no no no no up up Malaria Hypertrophic cardiomyopathy 0 -0.435770751 0 kegg kegg NA NA no no no no up up MAPK signaling pathway Hypertrophic cardiomyopathy 0 -0.537549407 0 kegg kegg NA NA no no no no up up Maturity onset diabetes of the young Hypertrophic cardiomyopathy -0.405217391 0 0 kegg kegg NA NA no up no no up up Melanogenesis Hypertrophic cardiomyopathy 0 0.484189723 0 kegg kegg NA NA no no no no up up Melanoma Hypertrophic cardiomyopathy -0.573043478 -0.675889328 -0.438095238 kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 Hypertrophic cardiomyopathy 0 0.669960474 0 kegg kegg NA NA no no no no up up MicroRNAs in cancer Hypertrophic cardiomyopathy 0 -0.740118577 0 kegg kegg NA NA no no no no up up Morphine addiction Hypertrophic cardiomyopathy 0 0.481225296 0 kegg kegg NA NA no up up no up up mRNA surveillance pathway Hypertrophic cardiomyopathy -0.605217391 0 0 kegg kegg NA NA no no no no up up mTOR signaling pathway Hypertrophic cardiomyopathy -0.46173913 0 -0.413899614 kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis Hypertrophic cardiomyopathy 0 -0.575098814 0 kegg kegg NA NA no no no no up up N-Glycan biosynthesis Hypertrophic cardiomyopathy 0 0.477272727 0 kegg kegg NA NA no no no no up up Natural killer cell mediated cytotoxicity Hypertrophic cardiomyopathy 0.451304348 0 0 kegg kegg NA NA no no no no up up Neurotrophin signaling pathway Hypertrophic cardiomyopathy -0.426956522 -0.540513834 0 kegg kegg NA NA no no no no up up Neutrophil extracellular trap formation Hypertrophic cardiomyopathy 0.448695652 0 0 kegg kegg NA NA no no no no up up NF-kappa B signaling pathway Hypertrophic cardiomyopathy 0 -0.730237154 -0.643758044 kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Hypertrophic cardiomyopathy 0 -0.505928854 0 kegg kegg NA NA no no no no up up Nitrogen metabolism Hypertrophic cardiomyopathy 0 -0.595849802 0 kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Hypertrophic cardiomyopathy 0 -0.699604743 0 kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease Hypertrophic cardiomyopathy 0 0.453557312 0.459202059 kegg kegg NA NA no no no no up up Non-small cell lung cancer Hypertrophic cardiomyopathy -0.433043478 -0.490118577 0 kegg kegg NA NA no no no no up up Oocyte meiosis Hypertrophic cardiomyopathy -0.480869565 0 0 kegg kegg NA NA no no no no up up Osteoclast differentiation Hypertrophic cardiomyopathy 0 -0.484189723 0 kegg kegg NA NA no no no no up up Other glycan degradation Hypertrophic cardiomyopathy 0 -0.423913043 0 kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis Hypertrophic cardiomyopathy -0.560869565 0 0 kegg kegg NA NA no no no no up up Ovarian steroidogenesis Hypertrophic cardiomyopathy 0.406086957 0 0 kegg kegg NA NA no up up no up up Oxidative phosphorylation Hypertrophic cardiomyopathy 0 0.565217391 0.504761905 kegg kegg NA NA no no no no up up Oxytocin signaling pathway Hypertrophic cardiomyopathy 0.888695652 0.761857708 0.665122265 kegg kegg NA NA no no no no up up p53 signaling pathway Hypertrophic cardiomyopathy -0.744347826 -0.622529644 -0.448133848 kegg kegg NA NA no no no no up up Pancreatic secretion Hypertrophic cardiomyopathy 0 0.56916996 0 kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis Hypertrophic cardiomyopathy 0 -0.486166008 0 kegg kegg NA NA no no dn no up up Parkinson disease Hypertrophic cardiomyopathy 0 0.45256917 0 kegg kegg NA NA no no no no up up Pathogenic Escherichia coli infection Hypertrophic cardiomyopathy 0.53826087 0 0.631145431 kegg kegg NA NA no no no no up up Pathways in cancer Hypertrophic cardiomyopathy -0.565217391 -0.536561265 -0.424967825 kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases Hypertrophic cardiomyopathy 0 0.416007905 0 kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer Hypertrophic cardiomyopathy -0.544347826 -0.779644269 -0.551866152 kegg kegg NA NA no no no no up up Pentose and glucuronate interconversions Hypertrophic cardiomyopathy 0 0.482213439 0 kegg kegg NA NA no no no no up up Pentose phosphate pathway Hypertrophic cardiomyopathy 0.48173913 0 0 kegg kegg NA NA no no no no up up Peroxisome Hypertrophic cardiomyopathy 0 -0.554347826 0 kegg kegg NA NA no no no no up up Phagosome Hypertrophic cardiomyopathy 0.586086957 0 0.418790219 kegg kegg NA NA no no no no up up Phenylalanine metabolism Hypertrophic cardiomyopathy 0.705217391 0.712450593 0.622651223 kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system Hypertrophic cardiomyopathy -0.554782609 0 0 kegg kegg NA NA no no no no up up Phospholipase D signaling pathway Hypertrophic cardiomyopathy 0 -0.433794466 0 kegg kegg NA NA no up up no up up Phototransduction Hypertrophic cardiomyopathy 0 0.545454545 0 kegg kegg NA NA no no no no up up Platelet activation Hypertrophic cardiomyopathy 0.911304348 0.941699605 0.872072072 kegg kegg NA NA no no no no up up Platinum drug resistance Hypertrophic cardiomyopathy -0.635652174 -0.501976285 0 kegg kegg NA NA no no no no up up PPAR signaling pathway Hypertrophic cardiomyopathy 0 -0.567193676 0 kegg kegg NA NA no no no no up up Prevotella Hypertrophic cardiomyopathy 0 -0.414653828 0 acetate-producing Genus kegg 0.287 NA no no no no up up Prion disease Hypertrophic cardiomyopathy 0 0.578063241 0.576833977 kegg kegg NA NA no no no no up up Progesterone-mediated oocyte maturation Hypertrophic cardiomyopathy -0.593913043 -0.457509881 0 kegg kegg NA NA no no no no up up Prolactin signaling pathway Hypertrophic cardiomyopathy 0 -0.468379447 0 kegg kegg NA NA no no no no up up Prostate cancer Hypertrophic cardiomyopathy -0.513913043 -0.603754941 -0.543371943 kegg kegg NA NA no no no no up up Proteasome Hypertrophic cardiomyopathy -0.611304348 0.470355731 0 kegg kegg NA NA no no no no up up Protein digestion and absorption Hypertrophic cardiomyopathy 0 -0.503952569 0 yes kegg kegg NA NA no up up no up up Protein export Hypertrophic cardiomyopathy -0.649565217 0.457509881 0 kegg kegg NA NA no no no no up up Proteoglycans in cancer Hypertrophic cardiomyopathy 0 0.479249012 0 kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation Hypertrophic cardiomyopathy 0 0.490118577 0 kegg kegg NA NA no no no no up up Pyrimidine metabolism Hypertrophic cardiomyopathy 0 0.507905138 0 kegg kegg NA NA no no no no up up Rap1 signaling pathway Hypertrophic cardiomyopathy 0.832173913 0.859683794 0.827027027 kegg kegg NA NA no no no no up up Ras signaling pathway Hypertrophic cardiomyopathy 0 0.570158103 0 yes kegg kegg NA NA no up up no up up Regulation of actin cytoskeleton Hypertrophic cardiomyopathy 0.653043478 0.66798419 0.685199485 kegg kegg NA NA no no no no up up Renal cell carcinoma Hypertrophic cardiomyopathy -0.419130435 0 -0.485971686 kegg kegg NA NA no no no no up up Renin secretion Hypertrophic cardiomyopathy 0 0.601778656 0 kegg kegg NA NA no no no no up up Retrograde endocannabinoid signaling Hypertrophic cardiomyopathy 0 0.623517787 0 kegg kegg NA NA no no up no up up Rheumatoid arthritis Hypertrophic cardiomyopathy 0 0 0.448133848 kegg kegg NA NA no no no no up up Ribosome Hypertrophic cardiomyopathy -0.427826087 0.420948617 0 kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes Hypertrophic cardiomyopathy -0.525217391 0 0 kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway Hypertrophic cardiomyopathy -0.546086957 -0.768774704 -0.602574003 kegg kegg NA NA no no no no up up RNA degradation Hypertrophic cardiomyopathy -0.593913043 0 0 kegg kegg NA NA no no no no up up RNA polymerase Hypertrophic cardiomyopathy -0.671304348 0 0 kegg kegg NA NA no no no no up up Salivary secretion Hypertrophic cardiomyopathy 0 0.59486166 0 kegg kegg NA NA no no no no up up Salmonella infection Hypertrophic cardiomyopathy 0 0 0.65971686 kegg kegg NA NA no no no no up up Selenocompound metabolism Hypertrophic cardiomyopathy -0.644347826 0 0 kegg kegg NA NA no no no no up up Signaling pathways regulating pluripotency of stem cells Hypertrophic cardiomyopathy -0.465217391 -0.437747036 0 kegg kegg NA NA no no no no up up Small cell lung cancer Hypertrophic cardiomyopathy -0.471304348 -0.654150198 -0.609266409 kegg kegg NA NA no no up no up up SNARE interactions in vesicular transport Hypertrophic cardiomyopathy 0 -0.656126482 0 kegg kegg NA NA no no no no up up Spinocerebellar ataxia Hypertrophic cardiomyopathy -0.874782609 0 0 kegg kegg NA NA no no no no up up Spliceosome Hypertrophic cardiomyopathy -0.66 -0.551383399 0 kegg kegg NA NA no no no no up up Staphylococcus aureus infection Hypertrophic cardiomyopathy 0.419130435 0 0 kegg kegg NA NA up no no no up up Starch and sucrose metabolism Hypertrophic cardiomyopathy 0 -0.480237154 0 kegg kegg NA NA no no no no up up Steroid hormone biosynthesis Hypertrophic cardiomyopathy 0 0.451581028 0 kegg kegg NA NA no no no no up up Sulfur metabolism Hypertrophic cardiomyopathy 0.459130435 0 0 kegg kegg NA NA no no no no up up T cell receptor signaling pathway Hypertrophic cardiomyopathy 0 -0.72826087 0 kegg kegg NA NA no no no no up up Taurine and hypotaurine metabolism Hypertrophic cardiomyopathy -0.406086957 -0.577075099 0 kegg kegg NA NA no no no no up up Terpenoid backbone biosynthesis Hypertrophic cardiomyopathy -0.522608696 0 0 kegg kegg NA NA no no no no up up TGF-beta signaling pathway Hypertrophic cardiomyopathy 0 0.450592885 0 kegg kegg NA NA no no no no up up Thermogenesis Hypertrophic cardiomyopathy 0 0.580039526 0.467953668 kegg kegg NA NA no no no no up up Thiamine metabolism Hypertrophic cardiomyopathy 0 0 -0.460746461 kegg kegg NA NA no no no no up up Thyroid hormone signaling pathway Hypertrophic cardiomyopathy 0.786956522 0.911067194 0.834491634 kegg kegg NA NA no no no no up up Tight junction Hypertrophic cardiomyopathy 0.786956522 0.863636364 0.692921493 kegg kegg NA NA no no no no up up TNF signaling pathway Hypertrophic cardiomyopathy -0.422608696 -0.621541502 0 kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway Hypertrophic cardiomyopathy 0 -0.575098814 0 yes kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Hypertrophic cardiomyopathy -0.765217391 -0.833003953 -0.702702703 kegg kegg NA NA no no no no up up Tryptophan metabolism Hypertrophic cardiomyopathy 0 0.445652174 0 kegg kegg NA NA no up no no up up Type I diabetes mellitus Hypertrophic cardiomyopathy 0.468695652 0 0 kegg kegg NA NA no no no no up up Type II diabetes mellitus Hypertrophic cardiomyopathy -0.492173913 -0.666007905 0 kegg kegg NA NA no no no no up up Tyrosine metabolism Hypertrophic cardiomyopathy 0 0.570158103 0 kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" Hypertrophic cardiomyopathy 0 0.441699605 0 kegg kegg NA NA no no no no up up Various types of N-glycan biosynthesis Hypertrophic cardiomyopathy -0.453913043 0 0 kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Hypertrophic cardiomyopathy 0 0.614624506 0 kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption Hypertrophic cardiomyopathy 0 0.548418972 0 kegg kegg NA NA no no no no up up Vibrio cholerae infection Hypertrophic cardiomyopathy 0.87826087 0.925889328 0.856113256 kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor Hypertrophic cardiomyopathy 0 0 0.514543115 kegg kegg NA NA no no no no up up Wnt signaling pathway Hypertrophic cardiomyopathy 0 0.464426877 0 kegg kegg NA NA no no no no up up Yersinia infection Hypertrophic cardiomyopathy 0.556521739 0 0.712998713 kegg kegg NA NA no no no no up up "12,13-EPOME+blood" Hypotaurine+blood 0 0 0.481162717 serum_ARA serum_aminoacids 0.901 0.933 no no no no no no 13-HODE+blood Hypotaurine+blood 0 0.56372549 0.428376068 serum_ARA serum_aminoacids 0.32 0.933 no no no no no no 14:0/18:2-PC+blood Hypotaurine+blood -0.493233083 0 0 serum_phospholipids serum_aminoacids 0.102 0.933 no up no no no no 16:0/18:0-PS+blood Hypotaurine+blood 0 -0.656862745 0 serum_phospholipids serum_aminoacids 0.377 0.933 no no no no no no 16:0/20:4-PI+blood Hypotaurine+blood 0 -0.556372549 0 serum_phospholipids serum_aminoacids 0.558 0.933 no no no no no no 16:0/22:0-PE+blood Hypotaurine+blood -0.682706767 0 0 serum_phospholipids serum_aminoacids 0.00839 0.933 dn no up no no no 16:0/22:6-PC+blood Hypotaurine+blood -0.562406015 0 0 serum_phospholipids serum_aminoacids 4.53E-05 0.933 no up up no no no 18:0-LPC+blood Hypotaurine+blood -0.57593985 0 0 serum_phospholipids serum_aminoacids 0.554 0.933 no no no no no no 18:0/18:0-PC+blood Hypotaurine+blood 0 -0.492647059 0 serum_phospholipids serum_aminoacids 0.426 0.933 no no no no no no 18:0/18:0-PS+blood Hypotaurine+blood 0 -0.759803922 0 serum_phospholipids serum_aminoacids 0.00617 0.933 no up no no no no 18:0/18:1-PC+blood Hypotaurine+blood 0 -0.507352941 0 serum_phospholipids serum_aminoacids 0.393 0.933 no no no no no no 18:0/20:3-PC+blood Hypotaurine+blood -0.556390977 0 0 serum_phospholipids serum_aminoacids 0.0682 0.933 no up no no no no 18:0/22:6-PC+blood Hypotaurine+blood -0.787969925 -0.517156863 0 serum_phospholipids serum_aminoacids 0.0775 0.933 no no up no no no 18:0/22:6-PE+blood Hypotaurine+blood 0 -0.549019608 0 serum_phospholipids serum_aminoacids 0.00022 0.933 up up no no no no 18:0/22:6-PI+blood Hypotaurine+blood -0.645112782 -0.620098039 0 serum_phospholipids serum_aminoacids 0.425 0.933 no no no no no no 18:1-LPE+blood Hypotaurine+blood 0 0.487745098 0 serum_phospholipids serum_aminoacids 0.117 0.933 no no no no no no 18:1/18:0-PS+blood Hypotaurine+blood 0 -0.549019608 0 serum_phospholipids serum_aminoacids 0.193 0.933 no no no no no no 18:1/18:1-PG+blood Hypotaurine+blood 0 -0.590686275 0 serum_phospholipids serum_aminoacids 0.00352 0.933 no up up no no no 18:2/20:4-PC+blood Hypotaurine+blood -0.476691729 0 0 serum_phospholipids serum_aminoacids 0.0145 0.933 no no up no no no 20:0/20:4-PE+blood Hypotaurine+blood 0.469172932 0 0 serum_phospholipids serum_aminoacids 0.00128 0.933 up up no no no no 20:1/20:4-PC+blood Hypotaurine+blood -0.806015038 0 0 serum_phospholipids serum_aminoacids 0.0419 0.933 no no up no no no 20:2-LPC+blood Hypotaurine+blood 0 0.529411765 0 serum_phospholipids serum_aminoacids 0.119 0.933 no no up no no no 20:2/18:0-PC+blood Hypotaurine+blood -0.551879699 0 0 serum_phospholipids serum_aminoacids 0.0427 0.933 no up no no no no 20:2/18:3-PE+blood Hypotaurine+blood 0.572932331 0 0 serum_phospholipids serum_aminoacids 0.0391 0.933 up up no no no no 20:3-LPE+blood Hypotaurine+blood 0.485714286 0 0 serum_phospholipids serum_aminoacids 0.084 0.933 no up no no no no 20:4-LPA+blood Hypotaurine+blood 0 0 0.545299145 serum_phospholipids serum_aminoacids 0.398 0.933 no no no no no no 20:5/18:0-PC+blood Hypotaurine+blood -0.70075188 0 0 serum_phospholipids serum_aminoacids 3.97E-06 0.933 no up up no no no 22:0/16:0-PE+blood Hypotaurine+blood -0.590977444 0 0 serum_phospholipids serum_aminoacids 0.091 0.933 no no up no no no 22:6-LPC+blood Hypotaurine+blood -0.533834586 0 0 serum_phospholipids serum_aminoacids 0.127 0.933 no no up no no no 22:6n3+blood Hypotaurine+blood -0.610526316 0 0 serum_fattyacid serum_aminoacids 0.792 0.933 no no no no no no 24:0+blood Hypotaurine+blood 0 0 -0.438632479 serum_fattyacid serum_aminoacids 0.034 0.933 dn no up no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Hypotaurine+blood -0.642857143 0 0 stool_cometabolism serum_aminoacids 0.33 0.933 no no no no no no 8-HETE+blood Hypotaurine+blood 0 0.693627451 0 serum_ARA serum_aminoacids 0.741 0.933 no no no no no no Adipocytokine signaling pathway Hypotaurine+blood 0 0.514705882 0 kegg serum_aminoacids NA 0.933 no no no no no no AGE-RAGE signaling pathway in diabetic complications Hypotaurine+blood -0.464912281 0 0 kegg serum_aminoacids NA 0.933 no no no no no no Arachidonic acid metabolism Hypotaurine+blood 0 0 -0.453076923 kegg serum_aminoacids NA 0.933 no no no no no no Asthma Hypotaurine+blood 0 -0.552941176 0 kegg serum_aminoacids NA 0.933 no no no no no no Autophagy - animal Hypotaurine+blood 0 0 0.532307692 kegg serum_aminoacids NA 0.933 no no no no no no Betaine+blood Hypotaurine+blood 0 0.526960784 0 serum_choline serum_aminoacids 0.857 0.933 no no no no no no Biosynthesis of cofactors Hypotaurine+blood 0 0 -0.462307692 kegg serum_aminoacids NA 0.933 no no no no no no Breast cancer Hypotaurine+blood 0 0 0.437692308 kegg serum_aminoacids NA 0.933 no no no no no no Butyricimonas Hypotaurine+blood -0.45101735 0 0 butyrate-producing Genus serum_aminoacids 0.17 0.933 no no no no no no cAMP signaling pathway Hypotaurine+blood 0 0.676470588 0 yes kegg serum_aminoacids NA 0.933 no up up no no no Central carbon metabolism in cancer Hypotaurine+blood 0 0 0.416153846 kegg serum_aminoacids NA 0.933 no no no no no no Choline metabolism in cancer Hypotaurine+blood 0 0 0.541538462 kegg serum_aminoacids NA 0.933 no no no no no no Choline+blood Hypotaurine+blood 0 0.720588235 0 serum_choline serum_aminoacids 0.0395 0.933 no up no no no no Chronic myeloid leukemia Hypotaurine+blood 0 0.532352941 0 kegg serum_aminoacids NA 0.933 no no no no no no Clostridium Hypotaurine+blood -0.488905638 -0.645077415 0 Genus serum_aminoacids 0.925 0.933 no no no no no no Cocaine addiction Hypotaurine+blood 0 0 -0.421538462 kegg serum_aminoacids NA 0.933 no no no no no no Colorectal cancer Hypotaurine+blood 0 0 0.51 kegg serum_aminoacids NA 0.933 no no no no no no Cytosolic DNA-sensing pathway Hypotaurine+blood 0 0.502941176 0 kegg serum_aminoacids NA 0.933 no no no no no no DHA+blood Hypotaurine+blood -0.527819549 0 0 serum_ARA serum_aminoacids 0.872 0.933 no no no no no no Endocrine and other factor-regulated calcium reabsorption Hypotaurine+blood 0 0 -0.423846154 kegg serum_aminoacids NA 0.933 no no no no no no EPA+blood Hypotaurine+blood -0.466165414 0 0 serum_ARA serum_aminoacids 0.212 0.933 no no no no no no ErbB signaling pathway Hypotaurine+blood 0 0 0.449230769 kegg serum_aminoacids NA 0.933 no no no no no no Ethanolamine+blood Hypotaurine+blood 0 0.50245098 0 serum_aminoacids serum_aminoacids 0.122 0.933 up no no no no no Ferroptosis Hypotaurine+blood 0 0.555882353 -0.52 kegg serum_aminoacids NA 0.933 no no no no no no FoxO signaling pathway Hypotaurine+blood 0 0 0.484615385 kegg serum_aminoacids NA 0.933 no no no no no no Gap junction Hypotaurine+blood 0 0.685294118 0 kegg serum_aminoacids NA 0.933 no no no no no no Gastric cancer Hypotaurine+blood 0 0 0.463846154 kegg serum_aminoacids NA 0.933 no no no no no no GDCA+blood Hypotaurine+blood 0 0.674019608 0 serum_bileacids serum_aminoacids 0.632 0.933 no no no no no no Glioma Hypotaurine+blood 0 0 0.583846154 kegg serum_aminoacids NA 0.933 no no no no no no Glutathione metabolism Hypotaurine+blood 0 0 -0.493076923 kegg serum_aminoacids NA 0.933 no no no no no no "Glycine, serine and threonine metabolism" Hypotaurine+blood 0 0 -0.463076923 kegg serum_aminoacids NA 0.933 no up no no no no Glycine+blood Hypotaurine+blood 0.506766917 0.588235294 0 serum_aminoacids serum_aminoacids 0.00408 0.933 dn no up no no no GPC+blood Hypotaurine+blood 0 0.659313725 0 serum_choline serum_aminoacids 0.00427 0.933 no up up no no no HDCA+blood Hypotaurine+blood 0 0.493782977 0 serum_bileacids serum_aminoacids 0.483 0.933 no no no no no no Inflammatory bowel disease Hypotaurine+blood 0 -0.564705882 0 kegg serum_aminoacids NA 0.933 no no no no no no Kaposi sarcoma-associated herpesvirus infection Hypotaurine+blood 0 0 -0.630769231 kegg serum_aminoacids NA 0.933 no no dn no no no Long-term depression Hypotaurine+blood 0 0.679411765 -0.423846154 kegg serum_aminoacids NA 0.933 no no no no no no Long-term potentiation Hypotaurine+blood -0.466666667 0 0 kegg serum_aminoacids NA 0.933 no no up no no no Malaria Hypotaurine+blood 0 0.6 -0.473846154 kegg serum_aminoacids NA 0.933 no no no no no no MAPK signaling pathway Hypotaurine+blood 0 0 0.536153846 kegg serum_aminoacids NA 0.933 no no no no no no MicroRNAs in cancer Hypotaurine+blood 0 0 0.51 kegg serum_aminoacids NA 0.933 no no no no no no Mineral absorption Hypotaurine+blood 0 0.526470588 -0.524615385 kegg serum_aminoacids NA 0.933 no no no no no no Mitophagy - animal Hypotaurine+blood 0 0 -0.456923077 kegg serum_aminoacids NA 0.933 no no no no no no Necroptosis Hypotaurine+blood 0 0.517647059 -0.48 kegg serum_aminoacids NA 0.933 no no no no no no Non-small cell lung cancer Hypotaurine+blood 0 0 0.543076923 kegg serum_aminoacids NA 0.933 no no no no no no Oocyte meiosis Hypotaurine+blood 0 -0.588235294 0 kegg serum_aminoacids NA 0.933 no no no no no no Pancreatic cancer Hypotaurine+blood 0 0 0.587692308 kegg serum_aminoacids NA 0.933 no no no no no no Pathways in cancer Hypotaurine+blood 0 0.532352941 0 kegg serum_aminoacids NA 0.933 no no no no no no Phosphatidylinositol signaling system Hypotaurine+blood 0 0 0.526153846 kegg serum_aminoacids NA 0.933 no no no no no no Porphyrin and chlorophyll metabolism Hypotaurine+blood 0 0 -0.490769231 kegg serum_aminoacids NA 0.933 no no no no no no Progesterone-mediated oocyte maturation Hypotaurine+blood 0 0 0.592307692 kegg serum_aminoacids NA 0.933 no no no no no no Prostate cancer Hypotaurine+blood 0 0.558823529 0 kegg serum_aminoacids NA 0.933 no no no no no no Proteasome Hypotaurine+blood 0 -0.602941176 0 kegg serum_aminoacids NA 0.933 no no no no no no Relaxin signaling pathway Hypotaurine+blood 0 0.664705882 0 kegg serum_aminoacids NA 0.933 no no no no no no Ruminococcus Hypotaurine+blood -0.445467329 0 0 Genus serum_aminoacids 0.0679 0.933 no no dn no no no Serotonergic synapse Hypotaurine+blood 0 0.505882353 0 kegg serum_aminoacids NA 0.933 no no no no no no Shigellosis Hypotaurine+blood 0 0 -0.511538462 kegg serum_aminoacids NA 0.933 no no no no no no Signaling pathways regulating pluripotency of stem cells Hypotaurine+blood 0 0 0.494615385 kegg serum_aminoacids NA 0.933 no no no no no no Sphingolipid signaling pathway Hypotaurine+blood 0 0 0.656153846 kegg serum_aminoacids NA 0.933 no no no no no no Spinocerebellar ataxia Hypotaurine+blood 0 0 0.415384615 kegg serum_aminoacids NA 0.933 no no no no no no Thyroid hormone synthesis Hypotaurine+blood 0 0 -0.600769231 kegg serum_aminoacids NA 0.933 no no no no no no Ubiquitin mediated proteolysis Hypotaurine+blood 0 0 -0.45 kegg serum_aminoacids NA 0.933 no no no no no no FGF basic IL-13 -0.637362637 0 0 yes serum_cytokines serum_cytokines 0.65 0.00264 no no no up up no GM-CSF IL-13 0.604395604 0.675324675 0.471412681 yes yes serum_cytokines serum_cytokines 0.0124 0.00264 up no no up up no 2-Oxocarboxylic acid metabolism IL-17 signaling pathway -0.45826087 -0.707509881 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes IL-17 signaling pathway 0 -0.649209486 -0.51969112 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" IL-17 signaling pathway 0.645217391 0.717391304 0.651222651 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis IL-17 signaling pathway 0 -0.656126482 -0.536422136 kegg kegg NA NA no no no no no no AMPK signaling pathway IL-17 signaling pathway -0.62173913 -0.563241107 0 kegg kegg NA NA no no no no no no Antifolate resistance IL-17 signaling pathway 0 -0.659090909 0 kegg kegg NA NA no no no no no no Apelin signaling pathway IL-17 signaling pathway 0 -0.542490119 0 kegg kegg NA NA no no no no no no Apoptosis IL-17 signaling pathway 0.442608696 0.766798419 0.619305019 kegg kegg NA NA no no no no no no Arginine and proline metabolism IL-17 signaling pathway 0.602608696 0.736166008 0.744144144 kegg kegg NA NA no up no no no no Arginine biosynthesis IL-17 signaling pathway 0.694782609 0.746047431 0.731016731 kegg kegg NA NA no no no no no no Autophagy - animal IL-17 signaling pathway 0.524347826 0.492094862 0 kegg kegg NA NA no no no no no no Basal transcription factors IL-17 signaling pathway 0 -0.695652174 -0.571685972 kegg kegg NA NA no no no no no no Base excision repair IL-17 signaling pathway 0 -0.765810277 -0.637837838 kegg kegg NA NA no no no no no no Biosynthesis of amino acids IL-17 signaling pathway 0 0.839920949 0.733590734 kegg kegg NA NA no no no no no no Biosynthesis of cofactors IL-17 signaling pathway -0.687826087 -0.686758893 0 kegg kegg NA NA no no no no no no Butanoate metabolism IL-17 signaling pathway 0 -0.60770751 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway IL-17 signaling pathway 0.662608696 0.68972332 0.573745174 kegg kegg NA NA no no no no no no Calcium signaling pathway IL-17 signaling pathway 0 -0.427865613 0 kegg kegg NA NA no up up no no no Carbon metabolism IL-17 signaling pathway 0 0 0.574259974 kegg kegg NA NA no no no no no no Cardiac muscle contraction IL-17 signaling pathway 0 -0.552371542 -0.491119691 kegg kegg NA NA no no up no no no Cell adhesion molecules IL-17 signaling pathway 0 0.603754941 0 kegg kegg NA NA no no no no no no Cell cycle IL-17 signaling pathway 0 -0.910079051 -0.808751609 kegg kegg NA NA no no no no no no Cellular senescence IL-17 signaling pathway 0 0.591897233 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway IL-17 signaling pathway 0.756521739 0.925889328 0.597168597 kegg kegg NA NA no no no no no no Chemokine signaling pathway IL-17 signaling pathway 0.48173913 0.712450593 0.461776062 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) IL-17 signaling pathway -0.414782609 -0.57312253 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades IL-17 signaling pathway 0 0.852766798 0.493693694 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism IL-17 signaling pathway 0 -0.541501976 -0.6 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction IL-17 signaling pathway 0 0.442687747 0 kegg kegg NA NA no no no no no no DNA replication IL-17 signaling pathway -0.410434783 -0.807312253 -0.571685972 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 IL-17 signaling pathway 0 -0.625494071 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes IL-17 signaling pathway 0 -0.524703557 0 kegg kegg NA NA no no no no no no ECM-receptor interaction IL-17 signaling pathway -0.559130435 -0.443675889 -0.448391248 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance IL-17 signaling pathway 0 -0.463438735 0 kegg kegg NA NA no no no no no no Endocytosis IL-17 signaling pathway 0 0.622529644 0 kegg kegg NA NA no no no no no no Ether lipid metabolism IL-17 signaling pathway 0 -0.658102767 -0.546203346 kegg kegg NA NA no no no no no no Fanconi anemia pathway IL-17 signaling pathway 0 -0.703557312 -0.626254826 kegg kegg NA NA no no no no no no Fatty acid biosynthesis IL-17 signaling pathway 0.656521739 0.783596838 0.672072072 kegg kegg NA NA no no no no no no Fatty acid degradation IL-17 signaling pathway 0 0.526679842 0 kegg kegg NA NA no no no no no no Fatty acid metabolism IL-17 signaling pathway 0 0.600790514 0 kegg kegg NA NA no no no no no no Folate biosynthesis IL-17 signaling pathway 0 -0.526679842 0 kegg kegg NA NA no no no no no no FoxO signaling pathway IL-17 signaling pathway 0.452173913 0 0 kegg kegg NA NA no no no no no no Galactose metabolism IL-17 signaling pathway 0 0.42687747 0 kegg kegg NA NA no no no no no no Glutathione metabolism IL-17 signaling pathway -0.609565217 -0.565217391 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism IL-17 signaling pathway 0 0 -0.446846847 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" IL-17 signaling pathway -0.675652174 -0.542490119 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate IL-17 signaling pathway 0.632173913 0.462450593 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin IL-17 signaling pathway 0 -0.636363636 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate IL-17 signaling pathway 0 -0.434782609 -0.466666667 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation IL-17 signaling pathway 0.583478261 0.625494071 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series IL-17 signaling pathway 0 -0.618577075 -0.523809524 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis IL-17 signaling pathway 0 -0.544466403 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism IL-17 signaling pathway 0.550434783 0.782608696 0.768082368 kegg kegg NA NA no no no no no no Hedgehog signaling pathway IL-17 signaling pathway 0 -0.755928854 -0.575032175 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species IL-17 signaling pathway 0.690434783 0.489130435 0 kegg kegg NA NA no no no no no no Homologous recombination IL-17 signaling pathway 0 -0.498023715 -0.646589447 kegg kegg NA NA no no no no no no Inositol phosphate metabolism IL-17 signaling pathway 0 0 -0.485456885 kegg kegg NA NA no no no no no no Linoleic acid metabolism IL-17 signaling pathway 0 -0.435770751 0 kegg kegg NA NA no no no no no no Lysine degradation IL-17 signaling pathway 0 -0.638339921 -0.554182754 kegg kegg NA NA no no no no no no Lysosome IL-17 signaling pathway 0.724347826 0.89229249 0.811840412 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis IL-17 signaling pathway 0 -0.529644269 -0.557271557 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 IL-17 signaling pathway 0 -0.513833992 0 kegg kegg NA NA no no no no no no Mismatch repair IL-17 signaling pathway 0 -0.627470356 -0.426512227 kegg kegg NA NA no no no no no no Mitophagy - animal IL-17 signaling pathway 0 -0.41798419 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway IL-17 signaling pathway 0 -0.813241107 -0.631917632 kegg kegg NA NA no no no no no no mTOR signaling pathway IL-17 signaling pathway 0 -0.466403162 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis IL-17 signaling pathway -0.453913043 -0.836956522 -0.732561133 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity IL-17 signaling pathway 0 0.622529644 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction IL-17 signaling pathway 0.526956522 0.758893281 0.797683398 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation IL-17 signaling pathway 0.63826087 0.853754941 0.731531532 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway IL-17 signaling pathway 0.526086957 0.514822134 0.465379665 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism IL-17 signaling pathway 0.717391304 0.835968379 0.9001287 kegg kegg NA NA no no no no no no Nitrogen metabolism IL-17 signaling pathway 0.613913043 0.701581028 0.672329472 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway IL-17 signaling pathway 0.693913043 0.681818182 0.454311454 kegg kegg NA NA no no no no no no Nucleotide excision repair IL-17 signaling pathway -0.409565217 -0.790513834 -0.651480051 kegg kegg NA NA no no no no no no One carbon pool by folate IL-17 signaling pathway -0.493043478 -0.793478261 -0.737194337 kegg kegg NA NA no no no no no no Oocyte meiosis IL-17 signaling pathway 0 0 -0.613899614 kegg kegg NA NA no no no no no no Osteoclast differentiation IL-17 signaling pathway 0.840869565 0.871541502 0.926383526 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis IL-17 signaling pathway 0 -0.640316206 -0.616988417 kegg kegg NA NA no no no no no no Oxidative phosphorylation IL-17 signaling pathway 0 -0.518774704 -0.41956242 kegg kegg NA NA no no no no no no p53 signaling pathway IL-17 signaling pathway 0 0 -0.418790219 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis IL-17 signaling pathway 0.814782609 0.780632411 0.768082368 kegg kegg NA NA no no dn no no no Paraprevotella IL-17 signaling pathway 0 -0.494773936 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions IL-17 signaling pathway 0 -0.747035573 -0.581209781 kegg kegg NA NA no no no no no no Pentose phosphate pathway IL-17 signaling pathway 0.569565217 0.908102767 0.866151866 kegg kegg NA NA no no no no no no Peroxisome IL-17 signaling pathway 0.510434783 0.75 0.576319176 kegg kegg NA NA no no no no no no Phagosome IL-17 signaling pathway 0 0.752964427 0.499356499 kegg kegg NA NA no no no no no no Phenylalanine metabolism IL-17 signaling pathway -0.480869565 -0.5 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system IL-17 signaling pathway 0 -0.552371542 -0.572972973 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway IL-17 signaling pathway 0.406956522 0.440711462 0 kegg kegg NA NA no up up no no no Platinum drug resistance IL-17 signaling pathway 0 0 -0.475933076 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism IL-17 signaling pathway -0.630434783 -0.459486166 0 kegg kegg NA NA no no no no no no PPAR signaling pathway IL-17 signaling pathway 0.514782609 0.769762846 0.803603604 kegg kegg NA NA no no no no no no Prevotella IL-17 signaling pathway -0.404859139 0 0 acetate-producing Genus kegg 0.287 NA no no no no no no Propanoate metabolism IL-17 signaling pathway 0 -0.43972332 -0.441184041 kegg kegg NA NA no no no no no no Protein export IL-17 signaling pathway 0 -0.603754941 -0.527927928 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum IL-17 signaling pathway -0.588695652 -0.896245059 0 kegg kegg NA NA no no no no no no Purine metabolism IL-17 signaling pathway -0.58 -0.645256917 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism IL-17 signaling pathway 0 -0.742094862 0 kegg kegg NA NA no no no no no no Pyruvate metabolism IL-17 signaling pathway 0 -0.595849802 0 kegg kegg NA NA no no no no no no Ras signaling pathway IL-17 signaling pathway 0 -0.645256917 -0.503732304 yes kegg kegg NA NA no up up no no no Renin-angiotensin system IL-17 signaling pathway 0.73826087 0.858695652 0.685714286 kegg kegg NA NA no no no no no no Retinol metabolism IL-17 signaling pathway 0 -0.544466403 0 kegg kegg NA NA no no no no no no Ribosome IL-17 signaling pathway -0.44 -0.435770751 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes IL-17 signaling pathway -0.416521739 -0.845849802 -0.721492921 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway IL-17 signaling pathway 0.679130435 0.533596838 0.427284427 kegg kegg NA NA no no no no no no RNA degradation IL-17 signaling pathway 0 -0.82312253 -0.624967825 kegg kegg NA NA no no no no no no RNA polymerase IL-17 signaling pathway 0 -0.898221344 -0.637065637 kegg kegg NA NA no no no no no no Ruminococcus IL-17 signaling pathway -0.60173913 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Selenocompound metabolism IL-17 signaling pathway 0 -0.493083004 -0.468983269 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells IL-17 signaling pathway 0 0 -0.452252252 kegg kegg NA NA no no no no no no Sphingolipid metabolism IL-17 signaling pathway 0.446956522 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway IL-17 signaling pathway 0.507826087 0.572134387 0 kegg kegg NA NA no no no no no no Spliceosome IL-17 signaling pathway 0 -0.537549407 -0.594851995 kegg kegg NA NA no no no no no no Starch and sucrose metabolism IL-17 signaling pathway 0.586956522 0.731225296 0.477220077 kegg kegg NA NA no no no no no no Steroid biosynthesis IL-17 signaling pathway 0 0 -0.58043758 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies IL-17 signaling pathway 0 -0.614624506 -0.509137709 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis IL-17 signaling pathway 0 -0.461462451 -0.524066924 kegg kegg NA NA no no no no no no TGF-beta signaling pathway IL-17 signaling pathway 0 -0.482213439 -0.469498069 kegg kegg NA NA no no no no no no Thiamine metabolism IL-17 signaling pathway 0 -0.461462451 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway IL-17 signaling pathway 0.610434783 0.779644269 0.655341055 yes kegg kegg NA NA no no no no no no Tyrosine metabolism IL-17 signaling pathway -0.473043478 -0.555335968 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis IL-17 signaling pathway 0 -0.622529644 -0.543629344 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis IL-17 signaling pathway -0.459130435 -0.562252964 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" IL-17 signaling pathway 0 -0.618577075 -0.427284427 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis IL-17 signaling pathway 0 -0.739130435 -0.544401544 kegg kegg NA NA no no no no no no VEGF signaling pathway IL-17 signaling pathway 0.436521739 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor IL-17 signaling pathway 0 0.5256917 0 kegg kegg NA NA no no no no no no Wnt signaling pathway IL-17 signaling pathway 0 -0.852766798 -0.558558559 kegg kegg NA NA no no no no no no Eotaxin IL-17A 0 0 0.430478309 serum_cytokines serum_cytokines 0.393 0.855 no no no no no no FGF basic IL-17A 0.664835165 0.585714286 0.402892102 serum_cytokines serum_cytokines 0.65 0.855 no no no no no no GM-CSF IL-17A -0.708791209 -0.474025974 -0.413125695 yes serum_cytokines serum_cytokines 0.0124 0.855 up no no no no no IL-13 IL-17A -0.93956044 0 0 yes serum_cytokines serum_cytokines 0.00264 0.855 up up no no no no GM-CSF IL-1b 0 0 0.563070078 yes yes serum_cytokines serum_cytokines 0.0124 0.00358 up no no up up no IFN-g IL-1b -0.642857143 -0.444155844 0 yes serum_cytokines serum_cytokines 0.825 0.00358 no no no up up no IL-13 IL-1b 0.857142857 0.738961039 0.688542825 yes yes serum_cytokines serum_cytokines 0.00264 0.00358 up up no up up no IL-17A IL-1b -0.89010989 -0.572727273 0 yes serum_cytokines serum_cytokines 0.855 0.00358 no no no up up no 12-ketoDCA+stool IL-1ra 0 -0.644484351 0 yes stool_bileacids serum_cytokines 0.505 0.0288 no no no no up no 16:0/18:2-PI+blood IL-1ra 0 0.542857143 0 yes serum_phospholipids serum_cytokines 0.269 0.0288 no no no no up no 16:0/20:3-PC+blood IL-1ra -0.636363636 0 0 yes serum_phospholipids serum_cytokines 5.43E-06 0.0288 no up up no up no 16:0/20:4-PC+blood IL-1ra 0 -0.582142857 0 yes serum_phospholipids serum_cytokines 0.0262 0.0288 no up no no up no 16:0/20:4-PI+blood IL-1ra 0 0.689285714 0 yes serum_phospholipids serum_cytokines 0.558 0.0288 no no no no up no 16:0/20:5-PC+blood IL-1ra 0 0 0.523308271 yes serum_phospholipids serum_cytokines 0.628 0.0288 no no no no up no 18:0/18:0-PC+blood IL-1ra 0 0.532142857 0 yes serum_phospholipids serum_cytokines 0.426 0.0288 no no no no up no 18:0/18:1-PC+blood IL-1ra 0 0.514285714 0 yes serum_phospholipids serum_cytokines 0.393 0.0288 no no no no up no 18:0/18:2-PI+blood IL-1ra 0 0.514285714 0 yes serum_phospholipids serum_cytokines 0.179 0.0288 no no no no up no 18:0/20:3-PI+blood IL-1ra 0 0 -0.479699248 yes serum_phospholipids serum_cytokines 0.377 0.0288 no no no no up no 18:0/20:5-PC+blood IL-1ra 0 0 0.466165414 yes serum_phospholipids serum_cytokines 0.17 0.0288 no no no no up no 18:0/22:6-PA+blood IL-1ra 0 0.546428571 0 yes serum_phospholipids serum_cytokines 0.22 0.0288 no no no no up no 18:0/22:6-PE+blood IL-1ra 0 0 0.563909774 yes serum_phospholipids serum_cytokines 0.00022 0.0288 up up no no up no 18:1-LPC+blood IL-1ra -0.636363636 0 0 yes serum_phospholipids serum_cytokines 0.179 0.0288 no no no no up no 18:1/20:3-PC+blood IL-1ra -0.709090909 0 0 yes serum_phospholipids serum_cytokines 0.00872 0.0288 no up up no up no 18:2/20:4-PC+blood IL-1ra 0 -0.557142857 0 yes serum_phospholipids serum_cytokines 0.0145 0.0288 no no up no up no 20:0/20:5-PC+blood IL-1ra 0 0 0.547368421 yes serum_phospholipids serum_cytokines 0.882 0.0288 no no no no up no 20:1+blood IL-1ra -0.76969697 0 -0.590977444 yes yes serum_fattyacid serum_cytokines 2.56E-05 0.0288 dn dn dn no up no 20:3/16:0-PC+blood IL-1ra 0 -0.532142857 0 yes serum_phospholipids serum_cytokines 0.00405 0.0288 no up up no up no 24:0+blood IL-1ra 0.660606061 0 0 yes serum_fattyacid serum_cytokines 0.034 0.0288 dn no up no up no Adrenergic signaling in cardiomyocytes IL-1ra 0 -0.461654135 0 yes kegg serum_cytokines NA 0.0288 no no up no up no Aldosterone synthesis and secretion IL-1ra 0 -0.603007519 0 yes kegg serum_cytokines NA 0.0288 no up up no up no Betaine+blood IL-1ra -0.684848485 0 0 yes serum_choline serum_cytokines 0.857 0.0288 no no no no up no Breast cancer IL-1ra -0.598901099 0 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Calcium signaling pathway IL-1ra -0.587912088 -0.478195489 0 yes kegg serum_cytokines NA 0.0288 no up up no up no Carbon metabolism IL-1ra 0.587912088 0.590977444 0 yes kegg serum_cytokines NA 0.0288 no no no no up no CDCA+stool IL-1ra 0 0.594405594 0 yes stool_bileacids serum_cytokines 0.663 0.0288 no no no no up no Cell adhesion molecules IL-1ra 0 0.506766917 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Chemical carcinogenesis - receptor activation IL-1ra 0 -0.607518797 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Choline+blood IL-1ra -0.660606061 0 0 yes serum_choline serum_cytokines 0.0395 0.0288 no up no no up no Clostridium IL-1ra 0 0.506472394 0 yes Genus serum_cytokines 0.925 0.0288 no no no no up no Cocaine addiction IL-1ra 0 -0.571428571 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Colorectal cancer IL-1ra -0.675824176 0 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Cortisol synthesis and secretion IL-1ra 0 -0.589473684 0 yes kegg serum_cytokines NA 0.0288 no no up no up no Cushing syndrome IL-1ra 0 -0.661654135 0 yes kegg serum_cytokines NA 0.0288 no no up no up no Endocrine and other factor-regulated calcium reabsorption IL-1ra 0 -0.463157895 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Endocrine resistance IL-1ra 0 -0.62556391 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Gap junction IL-1ra 0 -0.488721805 0 yes kegg serum_cytokines NA 0.0288 no no no no up no GCA+stool IL-1ra 0 0.664335664 0 yes stool_bileacids serum_cytokines 0.0809 0.0288 no no no no up no GDCA+blood IL-1ra 0 -0.546428571 0 yes serum_bileacids serum_cytokines 0.632 0.0288 no no no no up no Glucagon signaling pathway IL-1ra 0 -0.472180451 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Glycolysis / Gluconeogenesis IL-1ra 0.67032967 0 0 yes kegg serum_cytokines NA 0.0288 no no no no up no GM-CSF IL-1ra 0 0 0.409121246 yes yes serum_cytokines serum_cytokines 0.0124 0.0288 up no no no up no GnRH signaling pathway IL-1ra 0 -0.70075188 0 yes kegg serum_cytokines NA 0.0288 no no no no up no GPC+blood IL-1ra 0 0 0.509774436 yes serum_choline serum_cytokines 0.00427 0.0288 no up up no up no "Growth hormone synthesis, secretion and action" IL-1ra 0 -0.565413534 0 yes kegg serum_cytokines NA 0.0288 no no no no up no HDCA+stool IL-1ra 0 -0.594405594 0 yes stool_bileacids serum_cytokines 0.176 0.0288 no no no no up no Hypotaurine+blood IL-1ra 0 -0.610714286 0 yes serum_aminoacids serum_cytokines 0.933 0.0288 no no no no up no IL-17A IL-1ra 0 0 -0.688097887 yes serum_cytokines serum_cytokines 0.855 0.0288 no no no no up no Insulin secretion IL-1ra 0 -0.658646617 0 yes yes kegg serum_cytokines NA 0.0288 no up up no up no iso-DCA+blood IL-1ra -0.660606061 -0.553571429 0 yes serum_bileacids serum_cytokines 0.38 0.0288 no no no no up no iso-LCA+stool IL-1ra 0 -0.797202797 0 yes stool_bileacids serum_cytokines 0.72 0.0288 no no no no up no L-2-Aminobutyric acid+blood IL-1ra 0 0 -0.542857143 yes yes serum_aminoacids serum_cytokines 0.000328 0.0288 up up no no up no L-Alanine+blood IL-1ra 0 -0.55 0 yes yes serum_aminoacids serum_cytokines 0.00138 0.0288 up up no no up no L-Arginine+blood IL-1ra -0.793939394 0 0 yes serum_aminoacids serum_cytokines 0.316 0.0288 no no no no up no L-Homocystine+blood IL-1ra -0.648484848 0 0 yes serum_aminoacids serum_cytokines 0.197 0.0288 no no no no up no L-Methionine+blood IL-1ra -0.672727273 0 0 yes serum_aminoacids serum_cytokines 0.626 0.0288 no no no no up no L-Phenylalanine+blood IL-1ra -0.709090909 0 0 yes yes serum_aminoacids serum_cytokines 0.0103 0.0288 up up no no up no L-Tryptophan+blood IL-1ra -0.818181818 0 0 yes serum_aminoacids serum_cytokines 0.164 0.0288 no no no no up no L-Tyrosine+blood IL-1ra -0.806060606 0 0 yes yes serum_aminoacids serum_cytokines 0.00913 0.0288 up up no no up no LCA+stool IL-1ra 0 -0.818181818 0 yes stool_bileacids serum_cytokines 0.314 0.0288 no no no no up no Legionellosis IL-1ra 0.642857143 0 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Long-term depression IL-1ra 0 -0.478195489 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Longevity regulating pathway - multiple species IL-1ra 0 0.544360902 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Melanogenesis IL-1ra 0 -0.497744361 0 yes kegg serum_cytokines NA 0.0288 no no no no up no P-hydroxyhippuric acid+urine IL-1ra 0 -0.5 0 yes urine_cometabolism serum_cytokines 0.436 0.0288 no no no no up no Pancreatic secretion IL-1ra 0 -0.506766917 0 yes kegg serum_cytokines NA 0.0288 no no no no up no "Parathyroid hormone synthesis, secretion and action" IL-1ra 0 -0.47518797 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Phagosome IL-1ra 0 0.446616541 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Phenylacetic acid+stool IL-1ra -0.842424242 0 -0.632352941 yes stool_cometabolism serum_cytokines 0.785 0.0288 no no no no up no Phospholipase D signaling pathway IL-1ra -0.576923077 0 0 yes kegg serum_cytokines NA 0.0288 no up up no up no Primary immunodeficiency IL-1ra 0.626373626 0 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Proteasome IL-1ra 0 0 -0.459770115 yes kegg serum_cytokines NA 0.0288 no no no no up no Regulation of lipolysis in adipocytes IL-1ra 0 -0.497744361 0 yes kegg serum_cytokines NA 0.0288 no no no no up no Salivary secretion IL-1ra 0 0 0.49589491 yes kegg serum_cytokines NA 0.0288 no no no no up no Salmonella infection IL-1ra 0 0.645112782 0 yes kegg serum_cytokines NA 0.0288 no no no no up no TDCA+blood IL-1ra 0 -0.523784927 0 yes yes serum_bileacids serum_cytokines 0.155 0.0288 no up no no up no Thyroid hormone synthesis IL-1ra 0 -0.485714286 0 yes kegg serum_cytokines NA 0.0288 no no no no up no UDCA+stool IL-1ra 0 0.594405594 0 yes stool_bileacids serum_cytokines 0.266 0.0288 no no no no up no Vasopressin-regulated water reabsorption IL-1ra 0 -0.452631579 0 yes kegg serum_cytokines NA 0.0288 no no no no up no IFN-g IL-2 0.653846154 0.666233766 0.461179088 serum_cytokines serum_cytokines 0.825 0.522 no no no no no no IL-13 IL-2 -0.604395604 0 0 yes serum_cytokines serum_cytokines 0.00264 0.522 up up no no no no IL-1b IL-2 -0.554945055 -0.516883117 0 yes serum_cytokines serum_cytokines 0.00358 0.522 up up no no no no Eotaxin IL-4 0.659340659 0.838961039 0.688987764 serum_cytokines serum_cytokines 0.393 0.858 no no no no no no GM-CSF IL-4 -0.664835165 -0.577922078 0 yes serum_cytokines serum_cytokines 0.0124 0.858 up no no no no no IL-17A IL-4 0 0.611688312 0.799777531 serum_cytokines serum_cytokines 0.855 0.858 no no no no no no IL-1ra IL-4 0 0 -0.477641824 yes serum_cytokines serum_cytokines 0.0288 0.858 no up no no no no Adherens junction IL-6 0 0.527819549 0 kegg serum_cytokines NA 0.52 no no no no no no Alistipes IL-6 0 -0.50684308 0 Genus serum_cytokines 0.0114 0.52 no up no no no no Anaerostipes IL-6 0 -0.498193182 0 butyrate-producing Genus serum_cytokines 0.568 0.52 no no no no no no Antigen processing and presentation IL-6 0 0.445112782 0 kegg serum_cytokines NA 0.52 no no no no no no Asthma IL-6 0 0.520300752 0 kegg serum_cytokines NA 0.52 no no no no no no Bacterial invasion of epithelial cells IL-6 0 0.613533835 0 kegg serum_cytokines NA 0.52 no no no no no no Carbon metabolism IL-6 0 0.541353383 0 kegg serum_cytokines NA 0.52 no no no no no no Cell cycle IL-6 0 -0.479699248 0 kegg serum_cytokines NA 0.52 no no no no no no Chemical carcinogenesis - receptor activation IL-6 0 -0.469172932 0 kegg serum_cytokines NA 0.52 no no no no no no Clostridium IL-6 0 0.454244576 0 Genus serum_cytokines 0.925 0.52 no no no no no no Eotaxin IL-6 0 -0.571428571 -0.404226919 serum_cytokines serum_cytokines 0.393 0.52 no no no no no no Epstein-Barr virus infection IL-6 0 0.45112782 0 kegg serum_cytokines NA 0.52 no no no no no no ErbB signaling pathway IL-6 0 -0.509774436 0 kegg serum_cytokines NA 0.52 no no no no no no FGF basic IL-6 0.653846154 0 0 serum_cytokines serum_cytokines 0.65 0.52 no no no no no no Fluid shear stress and atherosclerosis IL-6 0 0.637593985 0 kegg serum_cytokines NA 0.52 no no no no no no Focal adhesion IL-6 0 0.541353383 0 kegg serum_cytokines NA 0.52 no up up no no no FoxO signaling pathway IL-6 0 -0.487218045 0 kegg serum_cytokines NA 0.52 no no no no no no Gastric cancer IL-6 0 -0.609022556 0 kegg serum_cytokines NA 0.52 no no no no no no Hippuric acid+urine IL-6 0 -0.717647059 0 urine_cometabolism serum_cytokines 0.361 0.52 no no no no no no IFN-g IL-6 0 0.849350649 0.576418242 serum_cytokines serum_cytokines 0.825 0.52 no no no no no no IL-13 IL-6 -0.681318681 0 0 yes serum_cytokines serum_cytokines 0.00264 0.52 up up no no no no IL-17 signaling pathway IL-6 0 0.509774436 0 kegg serum_cytokines NA 0.52 no no no no no no IL-17A IL-6 0.796703297 0 0 serum_cytokines serum_cytokines 0.855 0.52 no no no no no no IL-1b IL-6 -0.741758242 0 0 yes serum_cytokines serum_cytokines 0.00358 0.52 up up no no no no IL-2 IL-6 0 0.78961039 0.430923248 serum_cytokines serum_cytokines 0.522 0.52 no no no no no no JAK-STAT signaling pathway IL-6 0 -0.515789474 0 kegg serum_cytokines NA 0.52 no no no no no no Leishmaniasis IL-6 0 0.521804511 0 kegg serum_cytokines NA 0.52 no no no no no no Leukocyte transendothelial migration IL-6 0 0.679699248 0 kegg serum_cytokines NA 0.52 no no no no no no Lysosome IL-6 0 0.57443609 0 kegg serum_cytokines NA 0.52 no no no no no no MAPK signaling pathway IL-6 0 -0.473684211 0 kegg serum_cytokines NA 0.52 no no no no no no Non-small cell lung cancer IL-6 0 -0.593984962 0 kegg serum_cytokines NA 0.52 no no no no no no Oxytocin signaling pathway IL-6 0 0.646616541 0 kegg serum_cytokines NA 0.52 no no no no no no p53 signaling pathway IL-6 0 -0.753383459 0 kegg serum_cytokines NA 0.52 no no no no no no Pancreatic cancer IL-6 0 -0.469172932 0 kegg serum_cytokines NA 0.52 no no no no no no Pathogenic Escherichia coli infection IL-6 0 0.487218045 0 kegg serum_cytokines NA 0.52 no no no no no no Pathways in cancer IL-6 0 -0.539849624 0 kegg serum_cytokines NA 0.52 no no no no no no Phosphatidylinositol signaling system IL-6 0 -0.445112782 0 kegg serum_cytokines NA 0.52 no no no no no no Platelet activation IL-6 0 0.618045113 0 kegg serum_cytokines NA 0.52 no no no no no no Platinum drug resistance IL-6 0 -0.711278195 0 kegg serum_cytokines NA 0.52 no no no no no no Progesterone-mediated oocyte maturation IL-6 0 -0.630075188 0 kegg serum_cytokines NA 0.52 no no no no no no Rap1 signaling pathway IL-6 0 0.532330827 0 kegg serum_cytokines NA 0.52 no no no no no no Regulation of actin cytoskeleton IL-6 0 0.606015038 0 kegg serum_cytokines NA 0.52 no no no no no no Ribosome biogenesis in eukaryotes IL-6 0 -0.445112782 0 kegg serum_cytokines NA 0.52 no no no no no no Signaling pathways regulating pluripotency of stem cells IL-6 0 -0.508270677 0 kegg serum_cytokines NA 0.52 no no no no no no Spinocerebellar ataxia IL-6 0 -0.44962406 0 kegg serum_cytokines NA 0.52 no no no no no no Spliceosome IL-6 0 -0.781954887 0 kegg serum_cytokines NA 0.52 no no no no no no Staphylococcus aureus infection IL-6 0 0.484210526 0 kegg serum_cytokines NA 0.52 up no no no no no Systemic lupus erythematosus IL-6 0 0.463157895 0 kegg serum_cytokines NA 0.52 no no no no no no T cell receptor signaling pathway IL-6 0 -0.547368421 0 kegg serum_cytokines NA 0.52 no no no no no no Tight junction IL-6 0 0.584962406 0 kegg serum_cytokines NA 0.52 no no no no no no Vibrio cholerae infection IL-6 0 0.476691729 0 kegg serum_cytokines NA 0.52 no no no no no no Eotaxin IL-8 0 -0.485714286 0 serum_cytokines serum_cytokines 0.393 0.579 no no no no no no GM-CSF IL-8 0 0 0.424694105 yes serum_cytokines serum_cytokines 0.0124 0.579 up no no no no no IFN-g IL-8 0.60989011 0.574025974 0 serum_cytokines serum_cytokines 0.825 0.579 no no no no no no IL-17A IL-8 0 0 -0.585761958 serum_cytokines serum_cytokines 0.855 0.579 no no no no no no IL-1ra IL-8 0 0.503896104 0.433147942 yes serum_cytokines serum_cytokines 0.0288 0.579 no up no no no no IL-2 IL-8 0.681318681 0.468831169 0 serum_cytokines serum_cytokines 0.522 0.579 no no no no no no IL-4 IL-8 0 0 -0.509232481 serum_cytokines serum_cytokines 0.858 0.579 no no no no no no IL-6 IL-8 0 0.528571429 0 serum_cytokines serum_cytokines 0.52 0.579 no no no no no no Odoribacter IL-8 0 0 0.404951476 butyrate-producing Genus serum_cytokines 0.798 0.579 no no no no no no 12-ketoDCA+blood IL-9 0 0.679066556 -0.528378343 serum_bileacids serum_cytokines 0.517 0.906 no no no no no no 16:0/18:3-PC+blood IL-9 0 0 0.547368421 serum_phospholipids serum_cytokines 0.00216 0.906 no up up no no no 16:1/18:2-PG+blood IL-9 0 -0.65 0 serum_phospholipids serum_cytokines 1.40E-08 0.906 no up up no no no 18:0/18:0-PC+blood IL-9 0 0 0.482706767 serum_phospholipids serum_cytokines 0.426 0.906 no no no no no no 18:0/18:1-PC+blood IL-9 0 0 0.488721805 serum_phospholipids serum_cytokines 0.393 0.906 no no no no no no 18:0/18:2-PI+blood IL-9 0 -0.539285714 0 serum_phospholipids serum_cytokines 0.179 0.906 no no no no no no 18:0/20:3-PI+blood IL-9 0 -0.546428571 0 serum_phospholipids serum_cytokines 0.377 0.906 no no no no no no 18:1/18:1-PE+blood IL-9 0.733333333 -0.528571429 0 serum_phospholipids serum_cytokines 1.03E-05 0.906 up up no no no no 18:1/18:2-PG+blood IL-9 0 -0.553571429 0 serum_phospholipids serum_cytokines 5.58E-07 0.906 no up up no no no 24:1+blood IL-9 -0.709090909 0 0 serum_fattyacid serum_cytokines 0.00582 0.906 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine IL-9 0 0 -0.464912281 urine_cometabolism serum_cytokines 0.0405 0.906 no dn dn no no no Alcoholism IL-9 0 -0.44962406 0 kegg serum_cytokines NA 0.906 no no no no no no Antigen processing and presentation IL-9 0 -0.54887218 0 kegg serum_cytokines NA 0.906 no no no no no no Chemical carcinogenesis - receptor activation IL-9 0 0.45112782 0 kegg serum_cytokines NA 0.906 no no no no no no Clostridium IL-9 0.574594405 -0.547704882 0 Genus serum_cytokines 0.925 0.906 no no no no no no Cystine+blood IL-9 -0.76969697 0 0 yes serum_aminoacids serum_cytokines 0.00028 0.906 up up no no no no d18:1-20:0-SM+blood IL-9 0.806060606 0 0 serum_phospholipids serum_cytokines 0.933 0.906 no no no no no no d18:1-22:0-SM+blood IL-9 0.660606061 0 0 serum_phospholipids serum_cytokines 0.522 0.906 no no no no no no DCA+stool IL-9 0 0 -0.492647059 stool_bileacids serum_cytokines 0.195 0.906 no no no no no no Eotaxin IL-9 -0.565934066 0.537662338 0 serum_cytokines serum_cytokines 0.393 0.906 no no no no no no Epstein-Barr virus infection IL-9 0 -0.566917293 0 kegg serum_cytokines NA 0.906 no no no no no no ErbB signaling pathway IL-9 0 0.445112782 0 kegg serum_cytokines NA 0.906 no no no no no no Ferroptosis IL-9 -0.631868132 0 0 kegg serum_cytokines NA 0.906 no no no no no no Gastric cancer IL-9 0 0.55037594 0 kegg serum_cytokines NA 0.906 no no no no no no GCA+stool IL-9 0 -0.706293706 0.600490196 stool_bileacids serum_cytokines 0.0809 0.906 no no no no no no GCDCA+stool IL-9 0 0 0.514705882 yes stool_bileacids serum_cytokines 0.0471 0.906 no dn no no no no GDCA+blood IL-9 0 0 -0.493233083 serum_bileacids serum_cytokines 0.632 0.906 no no no no no no GLCA+blood IL-9 0 0.537276633 -0.498298794 serum_bileacids serum_cytokines 0.319 0.906 no no no no no no HDCA+blood IL-9 0 0 -0.44992027 serum_bileacids serum_cytokines 0.483 0.906 no no no no no no HDCA+stool IL-9 0 0.608391608 0 stool_bileacids serum_cytokines 0.176 0.906 no no no no no no Hematopoietic cell lineage IL-9 0 0 -0.499726327 kegg serum_cytokines NA 0.906 no no no no no no Herpes simplex virus 1 infection IL-9 0 -0.484210526 0 kegg serum_cytokines NA 0.906 no no no no no no Human cytomegalovirus infection IL-9 0 -0.512781955 0 kegg serum_cytokines NA 0.906 no no dn no no no Human immunodeficiency virus 1 infection IL-9 0 -0.547368421 0 kegg serum_cytokines NA 0.906 no no no no no no Human T-cell leukemia virus 1 infection IL-9 0 -0.538345865 0 kegg serum_cytokines NA 0.906 no no no no no no Hypotaurine+blood IL-9 0 0 -0.448120301 serum_aminoacids serum_cytokines 0.933 0.906 no no no no no no IFN-g IL-9 0 -0.741558442 0 serum_cytokines serum_cytokines 0.825 0.906 no no no no no no IL-2 IL-9 0 -0.715584416 0 serum_cytokines serum_cytokines 0.522 0.906 no no no no no no IL-6 IL-9 0 -0.727272727 0 serum_cytokines serum_cytokines 0.52 0.906 no no no no no no IL-8 IL-9 0 -0.518181818 -0.661401557 serum_cytokines serum_cytokines 0.579 0.906 no no no no no no Influenza A IL-9 0 0 -0.468527641 kegg serum_cytokines NA 0.906 no no no no no no iso-LCA+stool IL-9 0 0.643356643 0 stool_bileacids serum_cytokines 0.72 0.906 no no no no no no L-Alanine+blood IL-9 -0.76969697 0 0 yes serum_aminoacids serum_cytokines 0.00138 0.906 up up no no no no L-Asparagine+blood IL-9 -0.709090909 0 0 serum_aminoacids serum_cytokines 0.784 0.906 no no no no no no L-Glutamic acid+blood IL-9 -0.83030303 0 0.514285714 yes serum_aminoacids serum_cytokines 6.20E-05 0.906 up up no no no no L-Glutamine+blood IL-9 -0.745454545 0 0 serum_aminoacids serum_cytokines 0.639 0.906 no no no no no no L-Lysine+blood IL-9 -0.696969697 0 0 yes serum_aminoacids serum_cytokines 0.0107 0.906 no up no no no no L-Methionine+blood IL-9 -0.636363636 0 0 serum_aminoacids serum_cytokines 0.626 0.906 no no no no no no L-Ornithine+blood IL-9 -0.696969697 0 0 serum_aminoacids serum_cytokines 0.175 0.906 no no no no no no LCA+stool IL-9 0 0.636363636 0 stool_bileacids serum_cytokines 0.314 0.906 no no no no no no Leukocyte transendothelial migration IL-9 0 -0.562406015 0 kegg serum_cytokines NA 0.906 no no no no no no Longevity regulating pathway - multiple species IL-9 0 0 -0.527093596 kegg serum_cytokines NA 0.906 no no no no no no Lysosome IL-9 0 -0.479699248 0 kegg serum_cytokines NA 0.906 no no no no no no Malaria IL-9 -0.615384615 0 0 kegg serum_cytokines NA 0.906 no no no no no no Mineral absorption IL-9 -0.642857143 0 0 kegg serum_cytokines NA 0.906 no no no no no no Necroptosis IL-9 -0.659340659 0 0 kegg serum_cytokines NA 0.906 no no no no no no Non-small cell lung cancer IL-9 0 0.538345865 0 kegg serum_cytokines NA 0.906 no no no no no no nutriCA+stool IL-9 0 -0.584521537 0 stool_bileacids serum_cytokines 0.481 0.906 no no no no no no p53 signaling pathway IL-9 0 0.642105263 0 kegg serum_cytokines NA 0.906 no no no no no no Platinum drug resistance IL-9 0 0.530827068 0 kegg serum_cytokines NA 0.906 no no no no no no Progesterone-mediated oocyte maturation IL-9 0 0.505263158 0 kegg serum_cytokines NA 0.906 no no no no no no Regulation of actin cytoskeleton IL-9 0 -0.551879699 0 kegg serum_cytokines NA 0.906 no no no no no no Rheumatoid arthritis IL-9 0 0 -0.468527641 kegg serum_cytokines NA 0.906 no no no no no no Ruminococcus IL-9 0.615384615 0 0 Genus serum_cytokines 0.0679 0.906 no no dn no no no Spliceosome IL-9 0 0.586466165 0 kegg serum_cytokines NA 0.906 no no no no no no Staphylococcus aureus infection IL-9 0 0 -0.464696223 kegg serum_cytokines NA 0.906 up no no no no no T cell receptor signaling pathway IL-9 0 0.469172932 0 kegg serum_cytokines NA 0.906 no no no no no no TCA+stool IL-9 0 -0.588442233 0 stool_bileacids serum_cytokines 0.458 0.906 no no no no no no TDCA+stool IL-9 0 -0.839990637 0 stool_bileacids serum_cytokines 0.963 0.906 no no no no no no TLCA+stool IL-9 0.668762 0 0 stool_bileacids serum_cytokines 0.243 0.906 no no no no no no Toxoplasmosis IL-9 0 0 -0.532019704 kegg serum_cytokines NA 0.906 no no no no no no Tuberculosis IL-9 0 0 -0.490421456 kegg serum_cytokines NA 0.906 no no dn no no no 5-Hydroxytryptamine+stool Indole-3-Acetic acid+stool 0 0.748251748 0.503952569 stool_cometabolism stool_cometabolism 0.00862 0.304 dn dn no no no no Acetic acid+stool Indole-3-Acetic acid+stool 0 0 -0.435770751 yes stool_scfa stool_cometabolism 0.0656 0.304 dn no no no no no Adrenergic signaling in cardiomyocytes Indole-3-Acetic acid+stool 0 0.618181818 0 kegg stool_cometabolism NA 0.304 no no up no no no Antigen processing and presentation Indole-3-Acetic acid+stool 0 -0.645454545 0 kegg stool_cometabolism NA 0.304 no no no no no no Asthma Indole-3-Acetic acid+stool 0 -0.772727273 0 kegg stool_cometabolism NA 0.304 no no no no no no Blautia Indole-3-Acetic acid+stool 0 -0.671328671 0 acetate-producing Genus stool_cometabolism 1.36E-05 0.304 up dn dn no no no Butyric acid+stool Indole-3-Acetic acid+stool -0.510835913 0 0 yes stool_scfa stool_cometabolism 0.102 0.304 dn no no no no no CA+stool Indole-3-Acetic acid+stool 0 -0.713286713 0 stool_bileacids stool_cometabolism 0.827 0.304 no no no no no no Caproic acid+stool Indole-3-Acetic acid+stool 0 0.664335664 0 stool_scfa stool_cometabolism 0.882 0.304 no no no no no no CDCA+stool Indole-3-Acetic acid+stool 0 -0.769230769 -0.428853755 stool_bileacids stool_cometabolism 0.663 0.304 no no no no no no Clostridium Indole-3-Acetic acid+stool 0 -0.671328671 0 Genus stool_cometabolism 0.925 0.304 no no no no no no Cortisol synthesis and secretion Indole-3-Acetic acid+stool 0 0.7 0 kegg stool_cometabolism NA 0.304 no no up no no no Endocrine resistance Indole-3-Acetic acid+stool 0 0.672727273 0 kegg stool_cometabolism NA 0.304 no no no no no no Epstein-Barr virus infection Indole-3-Acetic acid+stool 0 -0.645454545 0 kegg stool_cometabolism NA 0.304 no no no no no no Gap junction Indole-3-Acetic acid+stool 0 0.681818182 0 kegg stool_cometabolism NA 0.304 no no no no no no GCA+stool Indole-3-Acetic acid+stool 0 -0.727272727 0 stool_bileacids stool_cometabolism 0.0809 0.304 no no no no no no GCDCA+stool Indole-3-Acetic acid+stool 0 -0.811188811 0 yes stool_bileacids stool_cometabolism 0.0471 0.304 no dn no no no no GDCA+stool Indole-3-Acetic acid+stool 0 -0.732050159 0 stool_bileacids stool_cometabolism 0.656 0.304 no no no no no no Glutamatergic synapse Indole-3-Acetic acid+stool 0 0.790909091 0 kegg stool_cometabolism NA 0.304 no up up no no no Glycolysis / Gluconeogenesis Indole-3-Acetic acid+stool 0 -0.672727273 0 kegg stool_cometabolism NA 0.304 no no no no no no "Growth hormone synthesis, secretion and action" Indole-3-Acetic acid+stool 0 0.754545455 0 kegg stool_cometabolism NA 0.304 no no no no no no Herpes simplex virus 1 infection Indole-3-Acetic acid+stool 0 -0.727272727 0 kegg stool_cometabolism NA 0.304 no no no no no no Human immunodeficiency virus 1 infection Indole-3-Acetic acid+stool 0 -0.645454545 0 kegg stool_cometabolism NA 0.304 no no no no no no Human T-cell leukemia virus 1 infection Indole-3-Acetic acid+stool 0 -0.663636364 0 kegg stool_cometabolism NA 0.304 no no no no no no Intestinal immune network for IgA production Indole-3-Acetic acid+stool 0 -0.718181818 0 kegg stool_cometabolism NA 0.304 no no no no no no Phospholipase D signaling pathway Indole-3-Acetic acid+stool 0 0.709090909 0 kegg stool_cometabolism NA 0.304 no up up no no no Proteasome Indole-3-Acetic acid+stool 0 -0.654545455 0 kegg stool_cometabolism NA 0.304 no no no no no no Regulation of actin cytoskeleton Indole-3-Acetic acid+stool 0 -0.709090909 0 kegg stool_cometabolism NA 0.304 no no no no no no Regulation of lipolysis in adipocytes Indole-3-Acetic acid+stool 0 0.709090909 0 kegg stool_cometabolism NA 0.304 no no no no no no Serotonergic synapse Indole-3-Acetic acid+stool 0 0.709090909 0 kegg stool_cometabolism NA 0.304 no no no no no no Th1 and Th2 cell differentiation Indole-3-Acetic acid+stool 0 -0.609090909 0 kegg stool_cometabolism NA 0.304 no no no no no no Th17 cell differentiation Indole-3-Acetic acid+stool 0 -0.618181818 0 kegg stool_cometabolism NA 0.304 no no no no no no Toxoplasmosis Indole-3-Acetic acid+stool 0 -0.681818182 0 kegg stool_cometabolism NA 0.304 no no no no no no 12-ketoDCA+stool Indole-3-Acetic acid+urine 0 0 0.680082559 stool_bileacids urine_cometabolism 0.505 0.657 no no no no no no 16:0/18:0-PS+blood Indole-3-Acetic acid+urine 0 0 0.435064935 serum_phospholipids urine_cometabolism 0.377 0.657 no no no no no no 18:1/18:1-PE+blood Indole-3-Acetic acid+urine 0 0 0.525974026 serum_phospholipids urine_cometabolism 1.03E-05 0.657 up up no no no no 18:1/20:3-PC+blood Indole-3-Acetic acid+urine -0.509803922 0 0 serum_phospholipids urine_cometabolism 0.00872 0.657 no up up no no no 3-Hydroxy-L-kynurenine+urine Indole-3-Acetic acid+urine 0 0 -0.439316239 urine_cometabolism urine_cometabolism 0.401 0.657 no no no no no no 3-Hydroxytyramine hydrochloride+urine Indole-3-Acetic acid+urine -0.505263158 0 -0.458461538 urine_cometabolism urine_cometabolism 0.288 0.657 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine Indole-3-Acetic acid+urine -0.592481203 0 0 urine_cometabolism urine_cometabolism 0.973 0.657 no no no no no no 4-hydroxybenzoic acid+urine Indole-3-Acetic acid+urine 0 0.515789474 0 urine_cometabolism urine_cometabolism 0.52 0.657 no no no no no no 8-HETE+blood Indole-3-Acetic acid+urine -0.49754902 0 0 serum_ARA urine_cometabolism 0.741 0.657 no no no no no no Bifidobacterium Indole-3-Acetic acid+urine -0.517293233 0 0 acetate-producing Genus urine_cometabolism 0.105 0.657 no dn no no no no d18:1-20:1-SM+blood Indole-3-Acetic acid+urine -0.485294118 0 0 serum_phospholipids urine_cometabolism 0.0992 0.657 no no no no no no DCA+stool Indole-3-Acetic acid+urine 0.547252747 0 0 stool_bileacids urine_cometabolism 0.195 0.657 no no no no no no Dorea Indole-3-Acetic acid+urine -0.457142857 0 0 Genus urine_cometabolism 0.00362 0.657 up no dn no no no GDCA+blood Indole-3-Acetic acid+urine 0.600490196 0 0 serum_bileacids urine_cometabolism 0.632 0.657 no no no no no no Prevotella Indole-3-Acetic acid+urine 0.60574593 0 0 acetate-producing Genus urine_cometabolism 0.287 0.657 no no no no no no PUFA/MUFA+blood Indole-3-Acetic acid+urine -0.507352941 0 0 serum_fattyacid urine_cometabolism 0.00108 0.657 dn no up no no no PUFA%+blood Indole-3-Acetic acid+urine -0.56372549 0 0 serum_fattyacid urine_cometabolism 0.0013 0.657 dn no up no no no SFA%+blood Indole-3-Acetic acid+urine -0.50245098 0 0 serum_fattyacid urine_cometabolism 0.0236 0.657 no up no no no no UFA%+blood Indole-3-Acetic acid+urine -0.541666667 0 0 serum_fattyacid urine_cometabolism 0.0236 0.657 no dn no no no no Adrenergic signaling in cardiomyocytes Inflammatory bowel disease 0 -0.43972332 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Inflammatory bowel disease 0.465217391 0 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Inflammatory bowel disease 0 -0.448616601 0 kegg kegg NA NA no up up no no no AMPK signaling pathway Inflammatory bowel disease 0 -0.575098814 0 kegg kegg NA NA no no no no no no Anaerostipes Inflammatory bowel disease -0.430680786 0 0 butyrate-producing Genus kegg 0.568 NA no no no no no no Asthma Inflammatory bowel disease 0.87826087 0.875494071 0.958301158 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Inflammatory bowel disease 0 0.440711462 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Inflammatory bowel disease 0 0.440711462 0.59021879 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Inflammatory bowel disease 0 0 0.461518662 kegg kegg NA NA no no no no no no cAMP signaling pathway Inflammatory bowel disease 0 0 -0.492406692 yes kegg kegg NA NA no up up no no no Carbon metabolism Inflammatory bowel disease 0 0.666007905 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Inflammatory bowel disease 0 0.433794466 0 kegg kegg NA NA no no no no no no Chagas disease Inflammatory bowel disease 0 0 -0.417245817 kegg kegg NA NA no no no no no no Cholesterol metabolism Inflammatory bowel disease 0 0.552371542 0 yes kegg kegg NA NA no no up no no no Clostridium Inflammatory bowel disease 0 0.58071912 0 Genus kegg 0.925 NA no no no no no no Cocaine addiction Inflammatory bowel disease 0 -0.519762846 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Inflammatory bowel disease 0 -0.504940711 0 kegg kegg NA NA no no up no no no Cushing syndrome Inflammatory bowel disease 0 -0.504940711 0 kegg kegg NA NA no no up no no no Drug metabolism - cytochrome P450 Inflammatory bowel disease 0 0 0.505276705 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Inflammatory bowel disease 0 -0.471343874 0 kegg kegg NA NA no no no no no no Fatty acid elongation Inflammatory bowel disease 0 0.421936759 0.476962677 kegg kegg NA NA no no no no no no Folate biosynthesis Inflammatory bowel disease -0.41826087 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Inflammatory bowel disease 0 0 0.418275418 kegg kegg NA NA no no no no no no Gap junction Inflammatory bowel disease 0 -0.529644269 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Inflammatory bowel disease 0 -0.420948617 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Inflammatory bowel disease 0 -0.539525692 0 kegg kegg NA NA no up up no no no Glycolysis / Gluconeogenesis Inflammatory bowel disease 0 0 0.522265122 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Inflammatory bowel disease 0 0.42687747 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Inflammatory bowel disease 0 0 -0.415958816 kegg kegg NA NA no no no no no no GnRH signaling pathway Inflammatory bowel disease 0 -0.429841897 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Inflammatory bowel disease 0.723478261 0.770750988 0.838352638 kegg kegg NA NA no no no no no no Histidine metabolism Inflammatory bowel disease 0 0 0.408751609 kegg kegg NA NA no no no no no no Influenza A Inflammatory bowel disease 0 0.566205534 0.475418275 kegg kegg NA NA no no no no no no Insulin secretion Inflammatory bowel disease 0 -0.507905138 0 yes kegg kegg NA NA no up up no no no Intestinal immune network for IgA production Inflammatory bowel disease 0.754782609 0.701581028 0.826769627 kegg kegg NA NA no no no no no no Lachnospira Inflammatory bowel disease -0.409565217 0 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Long-term depression Inflammatory bowel disease 0 -0.442687747 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Inflammatory bowel disease 0 -0.581027668 0 kegg kegg NA NA no no no no no no Lysosome Inflammatory bowel disease 0 0.536561265 0 kegg kegg NA NA no no no no no no Malaria Inflammatory bowel disease 0 -0.62944664 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Inflammatory bowel disease 0.547826087 0 0 kegg kegg NA NA no up no no no no Measles Inflammatory bowel disease -0.452173913 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Inflammatory bowel disease 0 0 0.465894466 kegg kegg NA NA no no no no no no Mitophagy - animal Inflammatory bowel disease 0 -0.433794466 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Inflammatory bowel disease 0 0.445652174 0 kegg kegg NA NA up up up no no no Odoribacter Inflammatory bowel disease 0.444275267 0 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Ovarian steroidogenesis Inflammatory bowel disease 0 -0.558300395 0 kegg kegg NA NA no up up no no no p53 signaling pathway Inflammatory bowel disease 0 -0.462450593 0 kegg kegg NA NA no no no no no no Phagosome Inflammatory bowel disease 0 0.461462451 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Inflammatory bowel disease 0 0 -0.408494208 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Inflammatory bowel disease -0.420869565 0 0 yes kegg kegg NA NA no up up no no no Primary bile acid biosynthesis Inflammatory bowel disease 0 0 0.426512227 kegg kegg NA NA no no no no no no Protein digestion and absorption Inflammatory bowel disease 0.556521739 0.4743083 0 yes kegg kegg NA NA no up up no no no Purine metabolism Inflammatory bowel disease 0 -0.461462451 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Inflammatory bowel disease 0 -0.526679842 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Inflammatory bowel disease 0 0.442687747 0 kegg kegg NA NA no no no no no no Salmonella infection Inflammatory bowel disease 0 0.468379447 0 kegg kegg NA NA no no no no no no Shigellosis Inflammatory bowel disease 0 -0.418972332 0 kegg kegg NA NA no no no no no no Small cell lung cancer Inflammatory bowel disease 0 0 -0.414929215 kegg kegg NA NA no no up no no no Sphingolipid metabolism Inflammatory bowel disease 0 0.484189723 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Inflammatory bowel disease 0 0.640316206 0.473616474 kegg kegg NA NA up no no no no no T cell receptor signaling pathway Inflammatory bowel disease -0.47826087 0 0 kegg kegg NA NA no no no no no no Taste transduction Inflammatory bowel disease -0.470434783 0 0 kegg kegg NA NA no no up no no no Th1 and Th2 cell differentiation Inflammatory bowel disease 0.565217391 0.538537549 0.726640927 kegg kegg NA NA no no no no no no Th17 cell differentiation Inflammatory bowel disease 0.585217391 0.449604743 0.764993565 kegg kegg NA NA no no no no no no Thiamine metabolism Inflammatory bowel disease -0.413043478 0 0 kegg kegg NA NA no no no no no no Thyroid cancer Inflammatory bowel disease -0.513913043 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Inflammatory bowel disease 0 -0.517786561 0 kegg kegg NA NA no no no no no no Toxoplasmosis Inflammatory bowel disease 0.620869565 0.663043478 0.847104247 kegg kegg NA NA no no no no no no Tryptophan metabolism Inflammatory bowel disease 0 0.424901186 0 kegg kegg NA NA no up no no no no Tuberculosis Inflammatory bowel disease 0.500869565 0.585968379 0.504247104 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Inflammatory bowel disease 0 0.421936759 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Inflammatory bowel disease 0 -0.436758893 0 kegg kegg NA NA no no no no no no ABC transporters Inflammatory mediator regulation of TRP channels -0.693913043 0 0 kegg kegg NA NA no up up no no no Adherens junction Inflammatory mediator regulation of TRP channels 0 0.539525692 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Inflammatory mediator regulation of TRP channels 0.890434783 0.793478261 0.867953668 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Inflammatory mediator regulation of TRP channels -0.552173913 -0.768774704 -0.42033462 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Inflammatory mediator regulation of TRP channels -0.709565217 -0.649209486 -0.58970399 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Inflammatory mediator regulation of TRP channels -0.610434783 0 -0.467181467 kegg kegg NA NA no no no no no no AMPK signaling pathway Inflammatory mediator regulation of TRP channels 0 0.471343874 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Inflammatory mediator regulation of TRP channels 0 0.658102767 0 kegg kegg NA NA no no no no no no Apoptosis Inflammatory mediator regulation of TRP channels -0.612173913 -0.668972332 -0.455083655 kegg kegg NA NA no no no no no no Arginine and proline metabolism Inflammatory mediator regulation of TRP channels -0.674782609 -0.799407115 -0.476447876 kegg kegg NA NA no up no no no no Arginine biosynthesis Inflammatory mediator regulation of TRP channels -0.582608696 -0.721343874 -0.436550837 kegg kegg NA NA no no no no no no Autophagy - animal Inflammatory mediator regulation of TRP channels 0 -0.672924901 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.725296443 0 kegg kegg NA NA no no no no no no Basal transcription factors Inflammatory mediator regulation of TRP channels 0 0.482213439 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Inflammatory mediator regulation of TRP channels -0.53826087 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Inflammatory mediator regulation of TRP channels -0.569565217 -0.750988142 -0.60978121 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Inflammatory mediator regulation of TRP channels 0 0.470355731 0 kegg kegg NA NA no no no no no no Butyricimonas Inflammatory mediator regulation of TRP channels 0.460855682 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no C-type lectin receptor signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.7243083 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Inflammatory mediator regulation of TRP channels 0.825217391 0.719367589 0.747747748 kegg kegg NA NA no up up no no no cAMP signaling pathway Inflammatory mediator regulation of TRP channels 0.582608696 0 0.441698842 yes kegg kegg NA NA no up up no no no Carbon metabolism Inflammatory mediator regulation of TRP channels -0.466956522 0 -0.644787645 kegg kegg NA NA no no no no no no Cardiac muscle contraction Inflammatory mediator regulation of TRP channels 0.520869565 0.790513834 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Inflammatory mediator regulation of TRP channels 0 -0.549407115 0 kegg kegg NA NA no no no no no no Cell cycle Inflammatory mediator regulation of TRP channels 0 0.558300395 0.497039897 kegg kegg NA NA no no no no no no Cellular senescence Inflammatory mediator regulation of TRP channels 0 -0.473320158 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.695652174 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.56027668 0 kegg kegg NA NA no no no no no no Circadian entrainment Inflammatory mediator regulation of TRP channels 0.65826087 0.753952569 0.684684685 kegg kegg NA NA no up up no no no Circadian rhythm Inflammatory mediator regulation of TRP channels 0.513913043 0.449604743 0 kegg kegg NA NA no no no no no no Collinsella Inflammatory mediator regulation of TRP channels 0 -0.502230366 0 Genus kegg 0.128 NA no no no no no no Complement and coagulation cascades Inflammatory mediator regulation of TRP channels -0.500869565 -0.660079051 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Inflammatory mediator regulation of TRP channels 0 0.473320158 0 kegg kegg NA NA no no no no no no DNA replication Inflammatory mediator regulation of TRP channels 0 0.511857708 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Inflammatory mediator regulation of TRP channels 0.772173913 0.780632411 0.836550837 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Inflammatory mediator regulation of TRP channels 0 0.476284585 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Inflammatory mediator regulation of TRP channels -0.431304348 0.479249012 -0.615186615 kegg kegg NA NA no no no no no no ECM-receptor interaction Inflammatory mediator regulation of TRP channels 0 0 0.485456885 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Inflammatory mediator regulation of TRP channels 0 0.577075099 0 kegg kegg NA NA no no no no no no Endocrine resistance Inflammatory mediator regulation of TRP channels 0.760869565 0.510869565 0.743629344 kegg kegg NA NA no no no no no no Endocytosis Inflammatory mediator regulation of TRP channels 0 -0.51284585 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Inflammatory mediator regulation of TRP channels 0.406086957 0.518774704 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Inflammatory mediator regulation of TRP channels -0.444347826 -0.747035573 0 kegg kegg NA NA no no no no no no Fatty acid degradation Inflammatory mediator regulation of TRP channels -0.597391304 -0.693675889 -0.577091377 kegg kegg NA NA no no no no no no Fatty acid metabolism Inflammatory mediator regulation of TRP channels -0.667826087 -0.665019763 -0.471042471 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.709486166 -0.435006435 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Inflammatory mediator regulation of TRP channels -0.523478261 -0.658102767 0 kegg kegg NA NA no no no no no no Focal adhesion Inflammatory mediator regulation of TRP channels 0 0.457509881 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.457509881 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Inflammatory mediator regulation of TRP channels -0.729565217 -0.490118577 -0.717117117 kegg kegg NA NA no no no no no no GABAergic synapse Inflammatory mediator regulation of TRP channels 0 -0.559288538 0 kegg kegg NA NA no up up no no no Galactose metabolism Inflammatory mediator regulation of TRP channels -0.776521739 -0.638339921 -0.597168597 kegg kegg NA NA no no no no no no Gap junction Inflammatory mediator regulation of TRP channels 0.659130435 0 0.494208494 kegg kegg NA NA no no no no no no Glutamatergic synapse Inflammatory mediator regulation of TRP channels 0.570434783 0 0 kegg kegg NA NA no up up no no no Glutathione metabolism Inflammatory mediator regulation of TRP channels 0 0.628458498 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Inflammatory mediator regulation of TRP channels -0.613043478 0 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Inflammatory mediator regulation of TRP channels 0 0.440711462 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Inflammatory mediator regulation of TRP channels -0.420869565 -0.579051383 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Inflammatory mediator regulation of TRP channels 0.572173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Inflammatory mediator regulation of TRP channels 0 -0.494071146 -0.486743887 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Inflammatory mediator regulation of TRP channels -0.689565217 -0.755928854 -0.54002574 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Inflammatory mediator regulation of TRP channels 0.506086957 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Inflammatory mediator regulation of TRP channels 0 0.467391304 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Inflammatory mediator regulation of TRP channels 0 0.614624506 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Inflammatory mediator regulation of TRP channels 0 -0.692687747 -0.423166023 kegg kegg NA NA no no no no no no Histidine metabolism Inflammatory mediator regulation of TRP channels -0.62 0 -0.52046332 kegg kegg NA NA no no no no no no IL-17 signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.64229249 -0.564993565 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Inflammatory mediator regulation of TRP channels -0.423478261 -0.590909091 0 kegg kegg NA NA no no no no no no Long-term depression Inflammatory mediator regulation of TRP channels 0.748695652 0 0.657400257 kegg kegg NA NA no no no no no no Long-term potentiation Inflammatory mediator regulation of TRP channels 0.590434783 0 0 kegg kegg NA NA no no up no no no Lysosome Inflammatory mediator regulation of TRP channels 0 -0.53458498 -0.693178893 kegg kegg NA NA no no no no no no MAPK signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.501976285 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Inflammatory mediator regulation of TRP channels 0 0.429841897 0 kegg kegg NA NA no no no no no no Mitophagy - animal Inflammatory mediator regulation of TRP channels 0.546956522 0.608695652 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Inflammatory mediator regulation of TRP channels 0.475652174 0.673913043 0.43963964 kegg kegg NA NA no no no no no no mTOR signaling pathway Inflammatory mediator regulation of TRP channels 0 0.548418972 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Inflammatory mediator regulation of TRP channels 0 0.681818182 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Inflammatory mediator regulation of TRP channels 0 -0.449604743 0 kegg kegg NA NA no no no no no no Necroptosis Inflammatory mediator regulation of TRP channels 0.506956522 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Inflammatory mediator regulation of TRP channels 0 -0.554347826 -0.49034749 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.58201581 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Inflammatory mediator regulation of TRP channels -0.552173913 -0.580039526 -0.445302445 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Inflammatory mediator regulation of TRP channels -0.53826087 -0.71541502 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Inflammatory mediator regulation of TRP channels -0.537391304 -0.699604743 -0.595366795 kegg kegg NA NA no no no no no no Nitrogen metabolism Inflammatory mediator regulation of TRP channels -0.506956522 -0.663043478 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Inflammatory mediator regulation of TRP channels -0.608695652 -0.807312253 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Inflammatory mediator regulation of TRP channels 0 0.46541502 0 kegg kegg NA NA no no no no no no Olfactory transduction Inflammatory mediator regulation of TRP channels 0 -0.572134387 -0.58018018 kegg kegg NA NA no no no no no no One carbon pool by folate Inflammatory mediator regulation of TRP channels 0 0.540513834 0 kegg kegg NA NA no no no no no no Oocyte meiosis Inflammatory mediator regulation of TRP channels 0.517391304 0.419960474 0.545173745 kegg kegg NA NA no no no no no no Oscillospira Inflammatory mediator regulation of TRP channels 0 -0.424901186 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Inflammatory mediator regulation of TRP channels -0.67826087 -0.754940711 -0.490862291 kegg kegg NA NA no no no no no no Other glycan degradation Inflammatory mediator regulation of TRP channels -0.74 -0.450592885 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Inflammatory mediator regulation of TRP channels 0.509565217 0.801383399 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Inflammatory mediator regulation of TRP channels -0.413043478 -0.694664032 -0.659459459 kegg kegg NA NA no no dn no no no Paraprevotella Inflammatory mediator regulation of TRP channels 0 0.416075454 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Inflammatory mediator regulation of TRP channels 0 0.527667984 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Inflammatory mediator regulation of TRP channels -0.56173913 -0.619565217 -0.675160875 kegg kegg NA NA no no no no no no Peroxisome Inflammatory mediator regulation of TRP channels -0.579130435 -0.751976285 0 kegg kegg NA NA no no no no no no Phagosome Inflammatory mediator regulation of TRP channels 0 -0.530632411 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Inflammatory mediator regulation of TRP channels 0.587826087 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.414031621 0 kegg kegg NA NA no up up no no no Phototransduction Inflammatory mediator regulation of TRP channels 0.577391304 0 0 kegg kegg NA NA no no no no no no Platelet activation Inflammatory mediator regulation of TRP channels 0 0.504940711 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Inflammatory mediator regulation of TRP channels -0.413043478 -0.817193676 0 kegg kegg NA NA no no no no no no Prevotella Inflammatory mediator regulation of TRP channels 0 0 0.532951768 acetate-producing Genus kegg 0.287 NA no no no no no no Propanoate metabolism Inflammatory mediator regulation of TRP channels 0 0.416996047 0 kegg kegg NA NA no no no no no no Proteasome Inflammatory mediator regulation of TRP channels 0 0 -0.500643501 kegg kegg NA NA no no no no no no Protein export Inflammatory mediator regulation of TRP channels 0.51826087 0.648221344 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Inflammatory mediator regulation of TRP channels 0.448695652 0.625494071 0 kegg kegg NA NA no no no no no no Purine metabolism Inflammatory mediator regulation of TRP channels 0 0.449604743 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Inflammatory mediator regulation of TRP channels -0.545217391 0.470355731 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Inflammatory mediator regulation of TRP channels 0 0.537549407 0 kegg kegg NA NA no no no no no no Ras signaling pathway Inflammatory mediator regulation of TRP channels 0.464347826 0.59486166 0 yes kegg kegg NA NA no up up no no no Renin-angiotensin system Inflammatory mediator regulation of TRP channels 0 -0.574110672 -0.491891892 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Inflammatory mediator regulation of TRP channels 0 0.746047431 0 kegg kegg NA NA no no up no no no Ribosome Inflammatory mediator regulation of TRP channels 0.52173913 0.70256917 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Inflammatory mediator regulation of TRP channels 0 0.485177866 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.730237154 0 kegg kegg NA NA no no no no no no RNA degradation Inflammatory mediator regulation of TRP channels 0.502608696 0.698616601 0 kegg kegg NA NA no no no no no no RNA polymerase Inflammatory mediator regulation of TRP channels 0 0.649209486 0 kegg kegg NA NA no no no no no no Sarcina Inflammatory mediator regulation of TRP channels 0 -0.422326513 0 Genus kegg 0.0703 NA no no no no no no SNARE interactions in vesicular transport Inflammatory mediator regulation of TRP channels -0.673043478 -0.640316206 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Inflammatory mediator regulation of TRP channels 0 0 -0.545688546 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.424901186 0 kegg kegg NA NA no no no no no no Spliceosome Inflammatory mediator regulation of TRP channels 0 0 0.417503218 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Inflammatory mediator regulation of TRP channels -0.808695652 -0.753952569 -0.773745174 kegg kegg NA NA no no no no no no Steroid biosynthesis Inflammatory mediator regulation of TRP channels 0.540869565 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Inflammatory mediator regulation of TRP channels 0 -0.610671937 -0.743371943 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.559288538 0 kegg kegg NA NA no no no no no no Taste transduction Inflammatory mediator regulation of TRP channels 0 0.437747036 0 kegg kegg NA NA no no up no no no TGF-beta signaling pathway Inflammatory mediator regulation of TRP channels 0.507826087 0.673913043 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Inflammatory mediator regulation of TRP channels 0 -0.504940711 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Inflammatory mediator regulation of TRP channels 0 -0.548418972 0 kegg kegg NA NA no no no no no no Thermogenesis Inflammatory mediator regulation of TRP channels 0.551304348 0.826086957 0 kegg kegg NA NA no no no no no no Thiamine metabolism Inflammatory mediator regulation of TRP channels -0.473043478 0 0 kegg kegg NA NA no no no no no no TNF signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.62944664 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.758893281 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Inflammatory mediator regulation of TRP channels -0.419130435 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Inflammatory mediator regulation of TRP channels 0 0.450592885 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Inflammatory mediator regulation of TRP channels -0.426956522 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Inflammatory mediator regulation of TRP channels 0.591304348 0.675889328 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Inflammatory mediator regulation of TRP channels 0 0.493083004 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Inflammatory mediator regulation of TRP channels 0.752173913 0.813241107 0.607207207 kegg kegg NA NA no no no no no no VEGF signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.434782609 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Inflammatory mediator regulation of TRP channels 0.49826087 0.721343874 0 kegg kegg NA NA no no no no no no Adherens junction Influenza A 0.557391304 0 0.665122265 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Influenza A 0 -0.437747036 0 kegg kegg NA NA no up up no no no Alistipes Influenza A 0 -0.462606669 0 Genus kegg 0.0114 NA no up no no no no Amphetamine addiction Influenza A 0 -0.510869565 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Influenza A 0 -0.608695652 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Influenza A -0.704347826 0 0 kegg kegg NA NA no no no no no no Apoptosis Influenza A 0.654782609 0.561264822 0.701158301 kegg kegg NA NA no no no no no no Apoptosis - multiple species Influenza A 0 -0.492094862 -0.503474903 kegg kegg NA NA no no no no no no Autophagy - other Influenza A -0.563478261 0 -0.532046332 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Influenza A 0.587826087 0.51284585 0.63989704 kegg kegg NA NA no no no no no no Basal transcription factors Influenza A -0.539130435 -0.701581028 -0.607464607 kegg kegg NA NA no no no no no no Base excision repair Influenza A -0.486956522 -0.618577075 -0.493693694 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Influenza A 0 0.414031621 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Influenza A 0 -0.651185771 0 kegg kegg NA NA no no no no no no Carbon metabolism Influenza A 0 0.467391304 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Influenza A 0.56 0.7243083 0.576319176 kegg kegg NA NA no no no no no no Cell cycle Influenza A -0.665217391 -0.597826087 0 kegg kegg NA NA no no no no no no Cellular senescence Influenza A 0 0.636363636 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Influenza A 0 0.462450593 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Influenza A 0 0.420948617 0.52046332 kegg kegg NA NA no no no no no no Cholesterol metabolism Influenza A 0 0.692687747 0 yes kegg kegg NA NA no no up no no no Circadian rhythm Influenza A -0.527826087 -0.647233202 -0.522265122 kegg kegg NA NA no no no no no no Complement and coagulation cascades Influenza A 0 0.435770751 0.537966538 kegg kegg NA NA no no no no no no Coprococcus Influenza A -0.419130435 0 0 butyrate-producing Genus kegg 0.612 NA no no no no no no Cortisol synthesis and secretion Influenza A 0 -0.486166008 0 kegg kegg NA NA no no up no no no Cushing syndrome Influenza A 0 -0.593873518 0 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Influenza A -0.574782609 0 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Influenza A 0 0 0.426512227 kegg kegg NA NA no no no no no no DNA replication Influenza A -0.451304348 0 -0.433204633 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Influenza A -0.500869565 0 -0.405920206 kegg kegg NA NA no no no no no no Eggerthella Influenza A 0 -0.490667928 0 Genus kegg 0.912 NA no no no no no no Endocrine resistance Influenza A 0 -0.441699605 0 kegg kegg NA NA no no no no no no Endocytosis Influenza A 0 0.670948617 0.404890605 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Influenza A 0.426956522 0.443675889 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Influenza A -0.436521739 -0.427865613 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Influenza A 0 -0.5256917 0 kegg kegg NA NA no no no no no no Eubacterium Influenza A 0 0 -0.430162599 Genus kegg 0.0692 NA no no no no no no Fanconi anemia pathway Influenza A -0.477391304 -0.567193676 -0.477477477 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Influenza A 0.454782609 0 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Influenza A 0 0.438735178 0 kegg kegg NA NA no no no no no no Focal adhesion Influenza A 0.525217391 0 0.57992278 kegg kegg NA NA no up up no no no Galactose metabolism Influenza A 0.435652174 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Influenza A 0 0 0.608494208 kegg kegg NA NA no no no no no no Glucagon signaling pathway Influenza A -0.617391304 -0.473320158 -0.527670528 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Influenza A 0 -0.488142292 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Influenza A 0 -0.576086957 0 kegg kegg NA NA no up no no no no Glycosaminoglycan degradation Influenza A 0.417391304 0.537549407 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Influenza A -0.559130435 -0.537549407 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Influenza A 0 -0.510869565 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Influenza A 0 0 0.462805663 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Influenza A -0.573913043 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Influenza A 0.472173913 0 0.555212355 kegg kegg NA NA no no no no no no Homologous recombination Influenza A -0.449565217 -0.477272727 -0.502702703 kegg kegg NA NA no no no no no no IL-17 signaling pathway Influenza A 0 0.522727273 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Influenza A 0 -0.442687747 0 kegg kegg NA NA no no no no no no Insulin secretion Influenza A 0 -0.435770751 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Influenza A -0.683478261 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Influenza A 0 0.527667984 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Influenza A 0.584347826 0.506916996 0.664864865 kegg kegg NA NA no no no no no no Long-term potentiation Influenza A -0.58 0 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Influenza A 0 -0.457509881 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Influenza A -0.440869565 0 0 kegg kegg NA NA no no no no no no Lysine degradation Influenza A 0 -0.435770751 -0.402059202 kegg kegg NA NA no no no no no no Lysosome Influenza A 0.50173913 0.666996047 0.412355212 kegg kegg NA NA no no no no no no Mismatch repair Influenza A 0 -0.46541502 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Influenza A 0 0 -0.49034749 kegg kegg NA NA no no no no no no mTOR signaling pathway Influenza A -0.575652174 0 -0.453024453 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Influenza A -0.456521739 -0.458498024 -0.473873874 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Influenza A -0.587826087 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Influenza A 0.41826087 0.647233202 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Influenza A 0 0.475296443 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Influenza A 0.520869565 0.56027668 0.571171171 kegg kegg NA NA no no no no no no Nicotine addiction Influenza A 0.472173913 0 0 kegg kegg NA NA no up up no no no Nucleotide excision repair Influenza A -0.457391304 -0.559288538 -0.435006435 kegg kegg NA NA no no no no no no One carbon pool by folate Influenza A -0.428695652 -0.437747036 0 kegg kegg NA NA no no no no no no Oocyte meiosis Influenza A -0.593043478 0 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Influenza A -0.553043478 -0.554347826 -0.474646075 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Influenza A 0.444347826 0.490118577 0.492921493 kegg kegg NA NA no no no no no no p53 signaling pathway Influenza A -0.533043478 -0.530632411 -0.61956242 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Influenza A -0.446956522 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Influenza A 0.613913043 0.678853755 0.70965251 kegg kegg NA NA no no no no no no Pentose phosphate pathway Influenza A 0.506956522 0.586956522 0 kegg kegg NA NA no no no no no no Pertussis Influenza A 0.463478261 0.501976285 0.481081081 kegg kegg NA NA no no dn no no no Phagosome Influenza A 0.646086957 0.749011858 0.693178893 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Influenza A 0 -0.563241107 -0.403603604 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Influenza A 0.446086957 0 0 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Influenza A -0.623478261 0 -0.407464607 yes kegg kegg NA NA no up up no no no Platelet activation Influenza A 0.45826087 0 0.634491634 kegg kegg NA NA no no no no no no Platinum drug resistance Influenza A -0.41826087 -0.47826087 -0.484427284 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Influenza A 0 -0.5256917 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Influenza A -0.50173913 -0.531620553 0 kegg kegg NA NA no no no no no no Propanoate metabolism Influenza A -0.48 0 0 kegg kegg NA NA no no no no no no Protein export Influenza A -0.648695652 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Influenza A -0.600869565 -0.434782609 -0.401029601 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Influenza A -0.453913043 0 0 kegg kegg NA NA no no no no no no Purine metabolism Influenza A 0 -0.602766798 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Influenza A -0.412173913 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Influenza A 0.491304348 0.499011858 0.646846847 kegg kegg NA NA no no no no no no Renin-angiotensin system Influenza A 0 0.5256917 0 kegg kegg NA NA no no no no no no Retinol metabolism Influenza A 0 -0.416007905 0 kegg kegg NA NA no no no no no no Ribosome Influenza A -0.444347826 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Influenza A -0.573913043 -0.533596838 -0.457142857 kegg kegg NA NA no no no no no no RNA polymerase Influenza A -0.653043478 -0.513833992 -0.433719434 kegg kegg NA NA no no no no no no RNA transport Influenza A -0.502608696 0 0 kegg kegg NA NA no no no no no no Salmonella infection Influenza A 0 0.64229249 0.587902188 kegg kegg NA NA no no no no no no Selenocompound metabolism Influenza A -0.500869565 -0.68083004 -0.439382239 kegg kegg NA NA no no no no no no Sphingolipid metabolism Influenza A 0.516521739 0.47826087 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Influenza A 0 0.460474308 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Influenza A -0.554782609 0 0 kegg kegg NA NA no no no no no no Spliceosome Influenza A -0.594782609 -0.486166008 -0.518146718 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Influenza A 0.736521739 0.718379447 0.584555985 kegg kegg NA NA up no no no no no Steroid biosynthesis Influenza A -0.544347826 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Influenza A 0 0.414031621 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Influenza A -0.406956522 -0.56027668 0 kegg kegg NA NA no no no no no no Taste transduction Influenza A -0.591304348 -0.536561265 0 kegg kegg NA NA no no up no no no Terpenoid backbone biosynthesis Influenza A -0.587826087 -0.492094862 -0.444015444 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Influenza A 0.495652174 0.593873518 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Influenza A 0.456521739 0.491106719 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Influenza A 0.583478261 0 0.593050193 kegg kegg NA NA no no no no no no Tight junction Influenza A 0.434782609 0 0.507593308 kegg kegg NA NA no no no no no no Toxoplasmosis Influenza A 0.452173913 0.507905138 0.457400257 kegg kegg NA NA no no no no no no Tuberculosis Influenza A 0.719130435 0.658102767 0.564478764 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Influenza A 0.605217391 0.765810277 0.535135135 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Influenza A 0 0 -0.423938224 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Influenza A -0.683478261 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Influenza A 0.471304348 0 0.673101673 kegg kegg NA NA no no no no no no Yersinia infection Influenza A 0.576521739 0.730237154 0.753410553 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Inositol phosphate metabolism 0 0.530632411 0.492664093 kegg kegg NA NA no no no no no no Arginine biosynthesis Inositol phosphate metabolism 0 0 -0.4002574 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Inositol phosphate metabolism 0 0 0.633976834 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Inositol phosphate metabolism 0 0 0.415444015 kegg kegg NA NA no no no no no no Fatty acid degradation Inositol phosphate metabolism 0 0.475296443 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Inositol phosphate metabolism 0 0.599802372 0 kegg kegg NA NA no no no no no no Galactose metabolism Inositol phosphate metabolism 0.446956522 0.505928854 0.464864865 kegg kegg NA NA no no no no no no Glutathione metabolism Inositol phosphate metabolism -0.468695652 0 -0.477992278 kegg kegg NA NA no no no no no no Glycerolipid metabolism Inositol phosphate metabolism 0.666956522 0.846837945 0.807979408 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Inositol phosphate metabolism 0 -0.500988142 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Inositol phosphate metabolism 0 0.575098814 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Inositol phosphate metabolism 0 0 0.610810811 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Inositol phosphate metabolism 0 0 0.437065637 kegg kegg NA NA no no up no no no Histidine metabolism Inositol phosphate metabolism 0.446956522 0 0 kegg kegg NA NA no no no no no no Lysine degradation Inositol phosphate metabolism 0.424347826 0.753952569 0.788416988 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Inositol phosphate metabolism 0 0.597826087 0.737194337 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Inositol phosphate metabolism 0 0.613636364 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Inositol phosphate metabolism 0 0 0.589189189 kegg kegg NA NA no no no no no no Other glycan degradation Inositol phosphate metabolism 0 0.758893281 0.726640927 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Inositol phosphate metabolism 0 0.767786561 0.860746461 kegg kegg NA NA no no no no no no Oxidative phosphorylation Inositol phosphate metabolism 0 -0.490118577 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Inositol phosphate metabolism 0.429565217 0.798418972 0.81981982 kegg kegg NA NA no no no no no no Steroid biosynthesis Inositol phosphate metabolism 0 0 0.511969112 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Inositol phosphate metabolism 0 0 0.523809524 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Inositol phosphate metabolism 0 0 0.493693694 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Inositol phosphate metabolism 0.489565217 0.748023715 0.55032175 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Inositol phosphate metabolism 0.440869565 0 0.471299871 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Inositol phosphate metabolism 0.429565217 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Inositol phosphate metabolism 0 0 0.538223938 kegg kegg NA NA no no no no no no 12-ketoDCA+blood INS0h+clinic 0 -0.525893648 0 serum_bileacids clinic 0.517 0.0633 no no no no up no 14:0+blood INS0h+clinic 0.51496388 0 0 yes serum_fattyacid clinic 0.00572 0.0633 up no dn no up no 16:0/20:5-PC+blood INS0h+clinic 0.60371517 0 0 serum_phospholipids clinic 0.628 0.0633 no no no no up no 18:0/20:3-PC+blood INS0h+clinic 0 0 0.483076923 serum_phospholipids clinic 0.0682 0.0633 no up no no up no 18:0/20:3-PI+blood INS0h+clinic 0 0.571428571 0 serum_phospholipids clinic 0.377 0.0633 no no no no up no 18:0/20:4-PI+blood INS0h+clinic -0.653250774 0 0 serum_phospholipids clinic 0.167 0.0633 no no no no up no 18:0/22:6-PC+blood INS0h+clinic 0.55624355 0 0 serum_phospholipids clinic 0.0775 0.0633 no no up no up no 18:1-LPC+blood INS0h+clinic -0.624355005 0 0 serum_phospholipids clinic 0.179 0.0633 no no no no up no 18:2-LPC+blood INS0h+clinic 0 -0.642857143 0 serum_phospholipids clinic 0.00743 0.0633 dn no up no up no 18:2-LPE+blood INS0h+clinic 0 0 -0.505384615 serum_phospholipids clinic 0.112 0.0633 no no no no up no 18:2/18:2-PC+blood INS0h+clinic 0 -0.578571429 0 serum_phospholipids clinic 1.98E-05 0.0633 dn up up no up no 18:3n3+blood INS0h+clinic 0 0 -0.411538462 serum_fattyacid clinic 0.291 0.0633 no no no no up no 20:2/18:0-PC+blood INS0h+clinic 0 0 0.471538462 serum_phospholipids clinic 0.0427 0.0633 no up no no up no 20:3n6+blood INS0h+clinic 0 0.532142857 0.41 serum_fattyacid clinic 0.0884 0.0633 up no no no up no 20:5n3+blood INS0h+clinic 0.618163055 0 0 serum_fattyacid clinic 0.988 0.0633 no no no no up no Blautia INS0h+clinic 0 0.444381705 -0.424185748 acetate-producing Genus clinic 1.36E-05 0.0633 up dn dn no up no C-peptide INS0h+clinic 0.583003953 0.51552795 0 DM-assocaited hormones clinic 0.228 0.0633 no no no no up no CA+stool INS0h+clinic 0 0.618181818 0 stool_bileacids clinic 0.827 0.0633 no no no no up no CDCA+stool INS0h+clinic 0 0.890909091 0 stool_bileacids clinic 0.663 0.0633 no no no no up no Collinsella INS0h+clinic 0.538670637 0 0 Genus clinic 0.128 0.0633 no no no no up no Coprococcus INS0h+clinic 0 0.456804065 0 butyrate-producing Genus clinic 0.612 0.0633 no no no no up no Dorea INS0h+clinic 0 0.565377035 0 Genus clinic 0.00362 0.0633 up no dn no up no EPA+blood INS0h+clinic 0.529411765 0 0 serum_ARA clinic 0.212 0.0633 no no no no up no Gap junction INS0h+clinic 0.4432524 0 0 kegg clinic NA 0.0633 no no no no up no GCA+stool INS0h+clinic 0.582352941 0.627272727 0 stool_bileacids clinic 0.0809 0.0633 no no no no up no GCDCA+stool INS0h+clinic 0.802941176 0.7 0 yes stool_bileacids clinic 0.0471 0.0633 no dn no no up no "Glycine, serine and threonine metabolism" INS0h+clinic 0.424054207 0 0 kegg clinic NA 0.0633 no up no no up no HDCA+blood INS0h+clinic 0 -0.525893648 0 serum_bileacids clinic 0.483 0.0633 no no no no up no IP-10 INS0h+clinic 0 0.466666667 0 serum_cytokines clinic 0.394 0.0633 no no no no up no iso-LCA+blood INS0h+clinic 0 -0.567699746 0 serum_bileacids clinic 0.507 0.0633 no no no no up no L-Phenylalanine+blood INS0h+clinic 0 0.6 0 yes serum_aminoacids clinic 0.0103 0.0633 up up no no up no L-Proline+blood INS0h+clinic 0 0.653571429 0 yes serum_aminoacids clinic 0.00265 0.0633 up up no no up no L-Tryptophan+blood INS0h+clinic 0 0.553571429 0 serum_aminoacids clinic 0.164 0.0633 no no no no up no L-Tyrosine+blood INS0h+clinic 0 0.782142857 0 yes serum_aminoacids clinic 0.00913 0.0633 up up no no up no Leptin INS0h+clinic 0.558300395 0.428571429 0.493659282 DM-assocaited hormones clinic 0.706 0.0633 no no no no up no n3+blood INS0h+clinic 0.529411765 0 0 serum_fattyacid clinic 0.806 0.0633 no no no no up no n6/n3+blood INS0h+clinic -0.529411765 0 0 serum_fattyacid clinic 0.226 0.0633 no no no no up no Odoribacter INS0h+clinic -0.428956059 0 0 butyrate-producing Genus clinic 0.798 0.0633 no no no no up no Parabacteroides INS0h+clinic 0 -0.4432524 0 Genus clinic 4.19E-05 0.0633 no up up no up no PUFA/MUFA+blood INS0h+clinic 0.469556244 0 0 serum_fattyacid clinic 0.00108 0.0633 dn no up no up no Resistin INS0h+clinic -0.571146245 0 0 DM-assocaited hormones clinic 0.156 0.0633 no no no no up no Roseburia INS0h+clinic 0 0.570460345 0 butyrate-producing Genus clinic 0.495 0.0633 no no no no up no total_stool_scfa+stool INS0h+clinic 0 -0.627272727 0 stool_scfa clinic 0.0534 0.0633 dn no up no up no UDCA+stool INS0h+clinic 0 0.727272727 0 stool_bileacids clinic 0.266 0.0633 no no no no up no Visfatin INS0h+clinic -0.622529644 0 0 DM-assocaited hormones clinic 0.0229 0.0633 dn no up no up no C-peptide Insulin 0.768774704 0.784347826 0.444257703 yes DM-assocaited hormones DM-assocaited hormones 0.228 0.00058 no no no up up no Ghrelin Insulin 0 -0.559130435 -0.403641457 yes yes DM-assocaited hormones DM-assocaited hormones 0.0108 0.00058 dn no no up up no GIP Insulin 0 -0.536521739 0 yes DM-assocaited hormones DM-assocaited hormones 0.374 0.00058 no no no up up no 2-Oxocarboxylic acid metabolism Insulin resistance -0.585217391 -0.517786561 0 kegg kegg NA NA no no no no no no ABC transporters Insulin resistance 0 0.484189723 0 kegg kegg NA NA no up up no no no Adherens junction Insulin resistance -0.617391304 -0.654150198 -0.54028314 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Insulin resistance 0 0.694664032 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Insulin resistance 0 0.628458498 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Insulin resistance -0.419130435 0 0 kegg kegg NA NA no no no no no no Anaerostipes Insulin resistance 0 0 -0.401508502 butyrate-producing Genus kegg 0.568 NA no no no no no no Apelin signaling pathway Insulin resistance 0 -0.687747036 0 kegg kegg NA NA no no no no no no Apoptosis Insulin resistance 0 0.675889328 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Insulin resistance -0.502608696 0 -0.467438867 kegg kegg NA NA no no no no no no Arginine and proline metabolism Insulin resistance 0 0.615612648 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Insulin resistance 0 0.566205534 0 kegg kegg NA NA no no no no no no Autophagy - animal Insulin resistance 0.729565217 0.864624506 0 kegg kegg NA NA no no no no no no Autophagy - other Insulin resistance 0.787826087 0.570158103 0.627541828 kegg kegg NA NA no no no no no no Axon guidance Insulin resistance 0.432173913 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Insulin resistance 0.580869565 0.83201581 0.595366795 kegg kegg NA NA no no no no no no Basal transcription factors Insulin resistance 0.465217391 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Insulin resistance -0.648695652 -0.611660079 -0.625740026 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Insulin resistance -0.551304348 0 -0.46023166 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Insulin resistance -0.465217391 -0.48715415 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Insulin resistance -0.454782609 -0.608695652 -0.588416988 kegg kegg NA NA no no no no no no Butanoate metabolism Insulin resistance -0.488695652 -0.755928854 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Insulin resistance 0.789565217 0.827075099 0.735649936 kegg kegg NA NA no no no no no no Calcium signaling pathway Insulin resistance 0 0 0.46048906 kegg kegg NA NA no up up no no no cAMP signaling pathway Insulin resistance 0.531304348 0.624505929 0.457142857 yes kegg kegg NA NA no up up no no no Carbon metabolism Insulin resistance -0.675652174 -0.449604743 -0.546718147 kegg kegg NA NA no no no no no no Cardiac muscle contraction Insulin resistance 0 -0.490118577 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Insulin resistance -0.525217391 0 0 kegg kegg NA NA no no no no no no Cellular senescence Insulin resistance 0 0.446640316 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Insulin resistance 0 0.491106719 0 kegg kegg NA NA no no no no no no Cholinergic synapse Insulin resistance 0.506086957 0 0.453281853 kegg kegg NA NA no no no no no no Circadian entrainment Insulin resistance 0 -0.685770751 0 kegg kegg NA NA no up up no no no Circadian rhythm Insulin resistance 0.7 0 0.647104247 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Insulin resistance -0.489565217 -0.769762846 0 kegg kegg NA NA no no no no no no Clostridium Insulin resistance 0 -0.420766661 0 Genus kegg 0.925 NA no no no no no no Collinsella Insulin resistance 0 0 -0.438165286 Genus kegg 0.128 NA no no no no no no Complement and coagulation cascades Insulin resistance -0.448695652 0 -0.586615187 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Insulin resistance 0 -0.789525692 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Insulin resistance 0 0 -0.600514801 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Insulin resistance 0 0.656126482 0 kegg kegg NA NA no no no no no no DNA replication Insulin resistance 0 -0.659090909 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Insulin resistance 0 -0.583992095 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Insulin resistance -0.42173913 -0.7756917 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Insulin resistance -0.679130435 -0.799407115 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Insulin resistance 0 -0.504940711 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Insulin resistance 0.446086957 -0.517786561 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Insulin resistance 0.646086957 0.717391304 0.54980695 kegg kegg NA NA no no no no no no Estrogen signaling pathway Insulin resistance 0 -0.67687747 -0.477992278 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Insulin resistance 0 0.60770751 0 kegg kegg NA NA no no no no no no Fatty acid elongation Insulin resistance -0.60173913 -0.67687747 -0.582239382 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Insulin resistance 0.435652174 0.748023715 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Insulin resistance 0 0 -0.406177606 kegg kegg NA NA no no no no no no Focal adhesion Insulin resistance -0.706956522 -0.746047431 -0.599485199 kegg kegg NA NA no up up no no no FoxO signaling pathway Insulin resistance 0 0.613636364 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Insulin resistance 0 0.519762846 0 kegg kegg NA NA no no no no no no Galactose metabolism Insulin resistance 0 0.48715415 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Insulin resistance 0 -0.476284585 0 kegg kegg NA NA no no no no no no Glutathione metabolism Insulin resistance -0.439130435 -0.634387352 -0.454054054 kegg kegg NA NA no no no no no no Glycerolipid metabolism Insulin resistance 0 0.562252964 0.492406692 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Insulin resistance 0.563478261 0.5 0.479279279 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Insulin resistance -0.420869565 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Insulin resistance -0.633913043 -0.75 -0.584041184 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Insulin resistance 0 0.838932806 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Insulin resistance -0.65826087 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Insulin resistance -0.42173913 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Insulin resistance 0.505217391 0.520750988 0.526640927 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Insulin resistance 0 0.561264822 0 kegg kegg NA NA no no no no no no GnRH secretion Insulin resistance 0.668695652 0.769762846 0.565508366 kegg kegg NA NA no up up no no no Hedgehog signaling pathway Insulin resistance 0 0 0.601287001 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Insulin resistance 0 -0.500988142 -0.463835264 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Insulin resistance 0 -0.60770751 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Insulin resistance -0.673043478 -0.685770751 -0.518661519 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Insulin resistance 0.406086957 0.593873518 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Insulin resistance 0 -0.58201581 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Insulin resistance 0 0.442687747 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Insulin resistance 0 -0.635375494 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Insulin resistance 0 0.818181818 0 kegg kegg NA NA no no no no no no Lachnospira Insulin resistance 0 -0.50111195 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Leukocyte transendothelial migration Insulin resistance -0.551304348 0 -0.623166023 kegg kegg NA NA no no no no no no Long-term potentiation Insulin resistance 0 -0.611660079 0 kegg kegg NA NA no no up no no no Longevity regulating pathway - multiple species Insulin resistance 0 0 -0.547232947 kegg kegg NA NA no no no no no no Lysine degradation Insulin resistance 0.631304348 0 0.576576577 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Insulin resistance 0.595652174 0 0.567824968 kegg kegg NA NA no no no no no no Melanogenesis Insulin resistance 0 -0.496047431 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Insulin resistance -0.546956522 -0.793478261 -0.435521236 kegg kegg NA NA no no no no no no Mismatch repair Insulin resistance 0 -0.682806324 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Insulin resistance 0.685217391 0 0.56962677 kegg kegg NA NA no no no no no no mTOR signaling pathway Insulin resistance 0 -0.518774704 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Insulin resistance 0 -0.56916996 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Insulin resistance -0.423478261 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Insulin resistance 0.69826087 0.811264822 0.675933076 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Insulin resistance 0 0 -0.453539254 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Insulin resistance 0.590434783 0.920948617 0.788416988 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Insulin resistance 0 0.601778656 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Insulin resistance 0 0.553359684 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Insulin resistance 0 0.7243083 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Insulin resistance -0.606086957 -0.746047431 -0.602574003 kegg kegg NA NA no no no no no no Notch signaling pathway Insulin resistance 0.522608696 0.616600791 0.480823681 kegg kegg NA NA no no no no no no Nucleotide excision repair Insulin resistance 0 -0.62055336 0 kegg kegg NA NA no no no no no no One carbon pool by folate Insulin resistance 0 -0.609683794 0 kegg kegg NA NA no no no no no no Oocyte meiosis Insulin resistance 0 -0.767786561 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Insulin resistance 0 0.603754941 0 kegg kegg NA NA no no no no no no Other glycan degradation Insulin resistance 0 0.568181818 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Insulin resistance 0.74173913 0 0.492406692 kegg kegg NA NA no no no no no no Oxidative phosphorylation Insulin resistance 0 -0.546442688 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Insulin resistance -0.745217391 -0.5 -0.706306306 kegg kegg NA NA no no no no no no p53 signaling pathway Insulin resistance 0.673043478 0 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Insulin resistance 0 0.420948617 0 kegg kegg NA NA no no dn no no no Paraprevotella Insulin resistance -0.466995794 0 0 Genus kegg 0.118 NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Insulin resistance 0.433043478 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Insulin resistance -0.506956522 -0.679841897 0 kegg kegg NA NA no no no no no no Peroxisome Insulin resistance 0 0.414031621 0 kegg kegg NA NA no no no no no no Phagosome Insulin resistance -0.532173913 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Insulin resistance -0.752173913 -0.706521739 -0.507593308 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Insulin resistance 0.468695652 0 0.497039897 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Insulin resistance 0 0.735177866 0 kegg kegg NA NA no up up no no no Phototransduction Insulin resistance 0 -0.805335968 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Insulin resistance 0.48173913 0 0 yes kegg kegg NA NA no up up no no no Platelet activation Insulin resistance -0.722608696 -0.634387352 -0.56010296 kegg kegg NA NA no no no no no no Platinum drug resistance Insulin resistance 0.429565217 0 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Insulin resistance -0.412173913 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Insulin resistance 0 0.593873518 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Insulin resistance 0 -0.697628458 -0.614414414 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Insulin resistance 0.550434783 0 0.451994852 kegg kegg NA NA no no no no no no Prolactin signaling pathway Insulin resistance 0.440869565 0.736166008 0.513770914 kegg kegg NA NA no no no no no no Propanoate metabolism Insulin resistance 0 -0.774703557 0 kegg kegg NA NA no no no no no no Proteasome Insulin resistance 0 -0.733201581 0 kegg kegg NA NA no no no no no no Protein export Insulin resistance 0.420869565 -0.677865613 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Insulin resistance 0 -0.550395257 0 kegg kegg NA NA no no no no no no Pyramidobacter Insulin resistance 0 0 0.410901342 Genus kegg 0.45 NA no no no no no no Pyrimidine metabolism Insulin resistance -0.449565217 -0.635375494 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Insulin resistance 0 -0.787549407 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Insulin resistance -0.50173913 0 -0.462548263 kegg kegg NA NA no no no no no no Ras signaling pathway Insulin resistance 0 -0.59486166 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Insulin resistance -0.712173913 -0.725296443 -0.700643501 kegg kegg NA NA no no no no no no Relaxin signaling pathway Insulin resistance 0.6 0.750988142 0.452252252 kegg kegg NA NA no no no no no no Renin secretion Insulin resistance -0.5 -0.703557312 0 kegg kegg NA NA no no no no no no Retinol metabolism Insulin resistance -0.502608696 -0.556324111 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Insulin resistance 0 -0.654150198 0 kegg kegg NA NA no no up no no no Ribosome Insulin resistance 0.426086957 -0.577075099 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Insulin resistance 0.752173913 0.877470356 0.750579151 kegg kegg NA NA no no no no no no RNA degradation Insulin resistance 0.594782609 -0.424901186 0.531016731 kegg kegg NA NA no no no no no no RNA polymerase Insulin resistance 0.436521739 -0.436758893 0 kegg kegg NA NA no no no no no no RNA transport Insulin resistance 0 -0.462450593 0 kegg kegg NA NA no no no no no no Roseburia Insulin resistance -0.446086957 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Sarcina Insulin resistance 0 0.422326513 0 Genus kegg 0.0703 NA no no no no no no Selenocompound metabolism Insulin resistance 0.60173913 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Insulin resistance 0.68173913 0.518774704 0.542857143 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Insulin resistance 0 0.662055336 0.423680824 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Insulin resistance 0.431304348 0.428853755 0 kegg kegg NA NA no no no no no no Spliceosome Insulin resistance 0.542608696 0 0.466409266 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Insulin resistance 0 0.532608696 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Insulin resistance 0 -0.720355731 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Insulin resistance -0.513043478 -0.654150198 0 kegg kegg NA NA no no no no no no Sulfur metabolism Insulin resistance -0.559130435 -0.56027668 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Insulin resistance 0 -0.603754941 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Insulin resistance 0.584347826 0.657114625 0 kegg kegg NA NA no no no no no no Taste transduction Insulin resistance 0 -0.435770751 0.411325611 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Insulin resistance 0.596521739 0.745059289 0.603861004 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Insulin resistance 0 -0.650197628 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Insulin resistance 0 0.481225296 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Insulin resistance 0 0.543478261 0 kegg kegg NA NA no no no no no no Thermogenesis Insulin resistance 0 -0.599802372 0 kegg kegg NA NA no no no no no no Thiamine metabolism Insulin resistance 0 -0.62944664 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Insulin resistance -0.425217391 -0.468379447 0 kegg kegg NA NA no no no no no no Tight junction Insulin resistance -0.630434783 -0.725296443 -0.747490347 kegg kegg NA NA no no no no no no TNF signaling pathway Insulin resistance 0.766086957 0.927865613 0.61003861 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Insulin resistance 0.539130435 0.7756917 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Insulin resistance -0.537391304 -0.73715415 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Insulin resistance 0.731304348 0.836956522 0.562419562 kegg kegg NA NA no no no no no no Tyrosine metabolism Insulin resistance -0.72 -0.791501976 -0.722265122 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Insulin resistance 0 -0.624505929 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Insulin resistance 0 -0.70256917 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Insulin resistance 0 -0.444664032 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Insulin resistance 0 -0.650197628 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Insulin resistance 0.56173913 0.599802372 0.407464607 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Insulin resistance 0 0 -0.541570142 kegg kegg NA NA no no no no no no Wnt signaling pathway Insulin resistance 0 -0.421936759 0.502960103 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Insulin secretion 0 0 -0.484169884 yes kegg kegg NA NA no no no no up up Adrenergic signaling in cardiomyocytes Insulin secretion 0.51826087 0.750988142 0.737709138 yes kegg kegg NA NA no no up no up up "Alanine, aspartate and glutamate metabolism" Insulin secretion -0.448695652 0 0 yes kegg kegg NA NA no no no no up up alpha-Linolenic acid metabolism Insulin secretion -0.533913043 0 -0.685971686 yes kegg kegg NA NA no no no no up up Amino sugar and nucleotide sugar metabolism Insulin secretion -0.456521739 0 -0.523294723 yes kegg kegg NA NA no no no no up up AMPK signaling pathway Insulin secretion 0.564347826 0.658102767 0 yes kegg kegg NA NA no no no no up up Antigen processing and presentation Insulin secretion -0.58173913 -0.472332016 0 yes kegg kegg NA NA no no no no up up Arginine and proline metabolism Insulin secretion -0.685217391 0 0 yes kegg kegg NA NA no up no no up up Arginine biosynthesis Insulin secretion -0.485217391 0 0 yes kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism Insulin secretion 0 0 -0.581724582 yes kegg kegg NA NA no no no no up up beta-Alanine metabolism Insulin secretion 0 -0.43083004 -0.642213642 yes kegg kegg NA NA no no no no up up Biosynthesis of amino acids Insulin secretion -0.492173913 -0.739130435 -0.447876448 yes kegg kegg NA NA no no no no up up Biosynthesis of cofactors Insulin secretion 0 0.438735178 0 yes kegg kegg NA NA no no no no up up Biosynthesis of unsaturated fatty acids Insulin secretion 0 -0.416996047 -0.467438867 yes kegg kegg NA NA no no no no up up Butanoate metabolism Insulin secretion 0 0 -0.433462033 yes kegg kegg NA NA no no no no up up Calcium signaling pathway Insulin secretion 0.575652174 0.756916996 0.844272844 yes kegg kegg NA NA no up up no up up cAMP signaling pathway Insulin secretion 0 0 0.75006435 yes yes kegg kegg NA NA no up up no up up Carbon metabolism Insulin secretion -0.415652174 -0.756916996 -0.61956242 yes kegg kegg NA NA no no no no up up Cardiac muscle contraction Insulin secretion 0 0.529644269 0 yes kegg kegg NA NA no no up no up up Cell adhesion molecules Insulin secretion 0 -0.688735178 0 yes kegg kegg NA NA no no no no up up Cell cycle Insulin secretion 0 0.437747036 0 yes kegg kegg NA NA no no no no up up Cellular senescence Insulin secretion 0 -0.448616601 0 yes kegg kegg NA NA no no no no up up cGMP-PKG signaling pathway Insulin secretion 0 -0.616600791 0 yes kegg kegg NA NA no no no no up up Circadian entrainment Insulin secretion 0.424347826 0 0.64015444 yes kegg kegg NA NA no up up no up up Circadian rhythm Insulin secretion 0 0.599802372 0 yes kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) Insulin secretion 0 0 -0.56010296 yes kegg kegg NA NA no no no no up up Clostridium Insulin secretion 0 -0.493101849 0 yes Genus kegg 0.925 NA no no no no up up Complement and coagulation cascades Insulin secretion -0.426956522 -0.632411067 0 yes kegg kegg NA NA no no no no up up Cytokine-cytokine receptor interaction Insulin secretion 0 -0.484189723 0 yes kegg kegg NA NA no no no no up up Dopaminergic synapse Insulin secretion 0.494782609 0.604743083 0.763963964 yes kegg kegg NA NA no up no no up up Drug metabolism - other enzymes Insulin secretion -0.510434783 0 -0.576319176 yes kegg kegg NA NA no no no no up up Endocrine resistance Insulin secretion 0.86 0.818181818 0.763963964 yes kegg kegg NA NA no no no no up up Endocytosis Insulin secretion 0 -0.669960474 0 yes kegg kegg NA NA no no no no up up Ether lipid metabolism Insulin secretion 0.439130435 0.454545455 0 yes kegg kegg NA NA no no no no up up Fatty acid biosynthesis Insulin secretion -0.568695652 -0.441699605 0 yes kegg kegg NA NA no no no no up up Fatty acid degradation Insulin secretion -0.667826087 -0.523715415 -0.784041184 yes kegg kegg NA NA no no no no up up Fatty acid elongation Insulin secretion 0 -0.520750988 -0.514028314 yes kegg kegg NA NA no no no no up up Fatty acid metabolism Insulin secretion -0.643478261 -0.632411067 -0.719176319 yes kegg kegg NA NA no no no no up up Fc gamma R-mediated phagocytosis Insulin secretion -0.715652174 -0.753952569 -0.437837838 yes kegg kegg NA NA no no no no up up Fructose and mannose metabolism Insulin secretion 0 0 -0.507850708 yes kegg kegg NA NA no no no no up up GABAergic synapse Insulin secretion -0.5 0 0 yes kegg kegg NA NA no up up no up up Galactose metabolism Insulin secretion 0 -0.449604743 -0.525868726 yes kegg kegg NA NA no no no no up up Gap junction Insulin secretion 0.720869565 0.640316206 0.560875161 yes kegg kegg NA NA no no no no up up Glutamatergic synapse Insulin secretion 0.488695652 0 0.497554698 yes kegg kegg NA NA no up up no up up Glutathione metabolism Insulin secretion 0 0.447628458 0 yes kegg kegg NA NA no no no no up up "Glycine, serine and threonine metabolism" Insulin secretion 0.448695652 0.518774704 0 yes kegg kegg NA NA no up no no up up Glycolysis / Gluconeogenesis Insulin secretion 0 0 -0.542857143 yes kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate Insulin secretion 0.602608696 0 0 yes kegg kegg NA NA no no no no up up Glycosaminoglycan degradation Insulin secretion 0 -0.636363636 -0.46048906 yes kegg kegg NA NA no no up no up up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Insulin secretion 0 0.464426877 0 yes kegg kegg NA NA no no no no up up Glyoxylate and dicarboxylate metabolism Insulin secretion -0.528695652 -0.433794466 0 yes kegg kegg NA NA no no no no up up Hedgehog signaling pathway Insulin secretion 0.422608696 0 0 yes kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Insulin secretion -0.48173913 0 0 yes kegg kegg NA NA no no no no up up Histidine metabolism Insulin secretion -0.409565217 0 -0.719433719 yes kegg kegg NA NA no no no no up up IL-17 signaling pathway Insulin secretion -0.512173913 -0.584980237 0 yes kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels Insulin secretion 0.657391304 0.650197628 0.748519949 yes kegg kegg NA NA no no no no up up Long-term depression Insulin secretion 0.768695652 0.682806324 0.838095238 yes kegg kegg NA NA no no no no up up Longevity regulating pathway Insulin secretion 0.569565217 0 0 yes kegg kegg NA NA no no no no up up Longevity regulating pathway - multiple species Insulin secretion -0.41826087 -0.745059289 -0.46975547 yes kegg kegg NA NA no no no no up up Lysine degradation Insulin secretion 0 0.480237154 0 yes kegg kegg NA NA no no no no up up Lysosome Insulin secretion -0.422608696 -0.701581028 -0.42007722 yes kegg kegg NA NA no no no no up up Mannose type O-glycan biosynthesis Insulin secretion 0.468695652 0.450592885 0 yes kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 Insulin secretion -0.426086957 0 -0.416473616 yes kegg kegg NA NA no no no no up up Mitophagy - animal Insulin secretion 0.6 0.654150198 0 yes kegg kegg NA NA no no no no up up mRNA surveillance pathway Insulin secretion 0 0.627470356 0 yes kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis Insulin secretion -0.436521739 0 0 yes kegg kegg NA NA no no no no up up Natural killer cell mediated cytotoxicity Insulin secretion 0 -0.557312253 0 yes kegg kegg NA NA no no no no up up Necroptosis Insulin secretion 0.560869565 0.468379447 0 yes kegg kegg NA NA no no no no up up Neuroactive ligand-receptor interaction Insulin secretion -0.654782609 -0.791501976 -0.433204633 yes kegg kegg NA NA up up up no up up Neutrophil extracellular trap formation Insulin secretion -0.553043478 -0.670948617 0 yes kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Insulin secretion -0.690434783 -0.418972332 0 yes kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Insulin secretion -0.806956522 -0.418972332 0 yes kegg kegg NA NA no no no no up up Non-homologous end-joining Insulin secretion 0 -0.427865613 -0.417760618 yes kegg kegg NA NA no no no no up up Odoribacter Insulin secretion 0 -0.521546919 0 butyrate-producing yes Genus kegg 0.798 NA no no no no up up Olfactory transduction Insulin secretion -0.610434783 -0.653162055 -0.56010296 yes kegg kegg NA NA no no no no up up Osteoclast differentiation Insulin secretion -0.664347826 -0.584980237 0 yes kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis Insulin secretion 0 0.583003953 0 yes kegg kegg NA NA no no no no up up Oxidative phosphorylation Insulin secretion 0 0.498023715 0 yes kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis Insulin secretion -0.592173913 -0.576086957 -0.585842986 yes kegg kegg NA NA no no dn no up up Pentose phosphate pathway Insulin secretion 0 -0.730237154 -0.413899614 yes kegg kegg NA NA no no no no up up Peroxisome Insulin secretion -0.73826087 -0.644268775 0 yes kegg kegg NA NA no no no no up up Phagosome Insulin secretion 0 -0.708498024 0 yes kegg kegg NA NA no no no no up up Phospholipase D signaling pathway Insulin secretion 0 0 0.508365508 yes kegg kegg NA NA no up up no up up Porphyrin and chlorophyll metabolism Insulin secretion 0.417391304 0.421936759 0 yes kegg kegg NA NA no no no no up up PPAR signaling pathway Insulin secretion -0.542608696 -0.524703557 0 yes kegg kegg NA NA no no no no up up Prevotella Insulin secretion 0 0 0.501709768 acetate-producing yes Genus kegg 0.287 NA no no no no up up Primary bile acid biosynthesis Insulin secretion 0 -0.472332016 -0.484684685 yes kegg kegg NA NA no no no no up up Proteasome Insulin secretion 0 0 -0.516087516 yes kegg kegg NA NA no no no no up up Protein processing in endoplasmic reticulum Insulin secretion 0.417391304 0.418972332 0 yes kegg kegg NA NA no no no no up up Purine metabolism Insulin secretion 0.464347826 0.537549407 0 yes kegg kegg NA NA no no no no up up Pyrimidine metabolism Insulin secretion -0.46173913 0 0 yes kegg kegg NA NA no no no no up up Renin-angiotensin system Insulin secretion -0.626956522 -0.693675889 -0.447104247 yes kegg kegg NA NA no no no no up up Retinol metabolism Insulin secretion -0.483478261 0 -0.536679537 yes kegg kegg NA NA no no no no up up Ribosome Insulin secretion 0.435652174 0.422924901 0 yes kegg kegg NA NA no no no no up up RNA degradation Insulin secretion 0 0.486166008 0 yes kegg kegg NA NA no no no no up up RNA polymerase Insulin secretion 0 0.473320158 0 yes kegg kegg NA NA no no no no up up Serotonergic synapse Insulin secretion 0 0 0.434749035 yes kegg kegg NA NA no no no no up up Signaling pathways regulating pluripotency of stem cells Insulin secretion 0 0.449604743 0 yes kegg kegg NA NA no no no no up up Sphingolipid metabolism Insulin secretion 0 0 -0.446332046 yes kegg kegg NA NA no no no no up up Sphingolipid signaling pathway Insulin secretion 0 -0.428853755 0 yes kegg kegg NA NA no no no no up up Starch and sucrose metabolism Insulin secretion -0.633043478 -0.500988142 -0.604890605 yes kegg kegg NA NA no no no no up up Steroid hormone biosynthesis Insulin secretion 0 0 -0.569111969 yes kegg kegg NA NA no no no no up up Synaptic vesicle cycle Insulin secretion -0.459130435 -0.734189723 -0.521492921 yes kegg kegg NA NA no up up no up up Thermogenesis Insulin secretion 0.426086957 0.5 0 yes kegg kegg NA NA no no no no up up Tryptophan metabolism Insulin secretion 0 0 -0.586615187 yes kegg kegg NA NA no up no no up up Tyrosine metabolism Insulin secretion 0 0 -0.455855856 yes kegg kegg NA NA no no no no up up Ubiquitin mediated proteolysis Insulin secretion 0.685217391 0.681818182 0 yes kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" Insulin secretion 0 0 -0.507335907 yes kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Insulin secretion 0.516521739 0.447628458 0.598455598 yes kegg kegg NA NA no no no no up up Wnt signaling pathway Insulin secretion 0.466956522 0.477272727 0 yes kegg kegg NA NA no no no no up up 2-Oxocarboxylic acid metabolism Insulin signaling pathway 0 0.429841897 0 kegg kegg NA NA no no no no no no ABC transporters Insulin signaling pathway 0 -0.4743083 0 kegg kegg NA NA no up up no no no Adherens junction Insulin signaling pathway -0.485217391 0.42687747 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Insulin signaling pathway 0 0.606719368 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Insulin signaling pathway 0 -0.637351779 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Insulin signaling pathway 0 -0.760869565 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Insulin signaling pathway 0 0 0.407464607 kegg kegg NA NA no no no no no no Apelin signaling pathway Insulin signaling pathway 0.970434783 0.984189723 0.983268983 kegg kegg NA NA no no no no no no Apoptosis Insulin signaling pathway -0.597391304 -0.718379447 -0.604375804 kegg kegg NA NA no no no no no no Arginine and proline metabolism Insulin signaling pathway 0 -0.624505929 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Insulin signaling pathway 0 -0.595849802 -0.412870013 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Insulin signaling pathway 0 0 0.452252252 kegg kegg NA NA no no no no no no Autophagy - animal Insulin signaling pathway 0 -0.613636364 0 kegg kegg NA NA no no no no no no Autophagy - other Insulin signaling pathway 0.626956522 0 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Insulin signaling pathway 0 -0.616600791 0 kegg kegg NA NA no no no no no no Basal transcription factors Insulin signaling pathway 0.657391304 0 0.585842986 kegg kegg NA NA no no no no no no Base excision repair Insulin signaling pathway 0.54173913 0 0.566537967 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Insulin signaling pathway 0 -0.456521739 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Insulin signaling pathway 0 0.46541502 0 kegg kegg NA NA no no no no no no Butanoate metabolism Insulin signaling pathway 0 0.636363636 0.62960103 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Insulin signaling pathway 0 -0.576086957 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Insulin signaling pathway 0 0.657114625 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Insulin signaling pathway -0.470434783 0 0 kegg kegg NA NA no no no no no no Cell cycle Insulin signaling pathway 0.587826087 0.482213439 0.422393822 kegg kegg NA NA no no no no no no Cellular senescence Insulin signaling pathway 0 -0.4743083 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Insulin signaling pathway 0 -0.543478261 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Insulin signaling pathway 0 -0.445652174 -0.482882883 kegg kegg NA NA no no no no no no Circadian rhythm Insulin signaling pathway 0.443478261 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Insulin signaling pathway 0 0.622529644 0.622651223 kegg kegg NA NA no no no no no no Complement and coagulation cascades Insulin signaling pathway -0.491304348 -0.537549407 -0.465122265 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Insulin signaling pathway 0.473043478 0.830039526 0.673101673 kegg kegg NA NA no no no no no no DNA replication Insulin signaling pathway 0.559130435 0.587944664 0.674388674 kegg kegg NA NA no no no no no no Dopaminergic synapse Insulin signaling pathway 0 0.501976285 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Insulin signaling pathway 0 0.638339921 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Insulin signaling pathway 0 0.633399209 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Insulin signaling pathway 0 0.481225296 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Insulin signaling pathway 0.929565217 0.976284585 0.968597169 kegg kegg NA NA no no no no no no Endocytosis Insulin signaling pathway -0.437391304 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Insulin signaling pathway 0.485217391 0 0.523294723 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Insulin signaling pathway 0 -0.662055336 0 kegg kegg NA NA no no no no no no Fatty acid degradation Insulin signaling pathway 0 -0.493083004 0 kegg kegg NA NA no no no no no no Fatty acid elongation Insulin signaling pathway 0 0.428853755 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Insulin signaling pathway 0 -0.451581028 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Insulin signaling pathway 0 -0.776679842 -0.536679537 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Insulin signaling pathway -0.484347826 -0.493083004 0 kegg kegg NA NA no no no no no no Focal adhesion Insulin signaling pathway -0.493043478 0.42687747 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Insulin signaling pathway 0 -0.579051383 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Insulin signaling pathway 0 -0.662055336 0 kegg kegg NA NA no no no no no no GABAergic synapse Insulin signaling pathway 0 -0.45256917 -0.418790219 kegg kegg NA NA no up up no no no Galactose metabolism Insulin signaling pathway 0 -0.696640316 0 kegg kegg NA NA no no no no no no Gap junction Insulin signaling pathway 0 0 -0.447876448 kegg kegg NA NA no no no no no no Glutamatergic synapse Insulin signaling pathway 0 -0.486166008 -0.464092664 kegg kegg NA NA no up up no no no Glutathione metabolism Insulin signaling pathway 0 0.701581028 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Insulin signaling pathway 0 -0.624505929 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Insulin signaling pathway 0 -0.491106719 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Insulin signaling pathway 0 0.709486166 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Insulin signaling pathway 0 -0.7756917 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Insulin signaling pathway 0 -0.571146245 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - globo and isoglobo series Insulin signaling pathway 0 0 -0.407979408 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Insulin signaling pathway 0 -0.46541502 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Insulin signaling pathway 0 -0.561264822 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Insulin signaling pathway 0.923478261 0.950592885 0.925868726 kegg kegg NA NA no no no no no no Hippo signaling pathway Insulin signaling pathway 0 0.486166008 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Insulin signaling pathway 0 -0.731225296 0 kegg kegg NA NA no no no no no no Homologous recombination Insulin signaling pathway 0 0 0.463835264 kegg kegg NA NA no no no no no no IL-17 signaling pathway Insulin signaling pathway 0 -0.507905138 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Insulin signaling pathway 0 0.599802372 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Insulin signaling pathway 0 -0.740118577 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Insulin signaling pathway -0.550434783 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Insulin signaling pathway 0.416521739 0.70256917 0 kegg kegg NA NA no no up no no no Lysine degradation Insulin signaling pathway 0.648695652 0 0.402574003 kegg kegg NA NA no no no no no no Lysosome Insulin signaling pathway -0.467826087 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Insulin signaling pathway 0 0.579051383 0 kegg kegg NA NA no no no no no no Mismatch repair Insulin signaling pathway 0 0.549407115 0.554182754 kegg kegg NA NA no no no no no no Mitophagy - animal Insulin signaling pathway 0.408695652 0.550395257 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Insulin signaling pathway 0.533043478 0.56916996 0.502702703 kegg kegg NA NA no no no no no no mTOR signaling pathway Insulin signaling pathway 0.944347826 0.975296443 0.924581725 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Insulin signaling pathway 0.506086957 0.638339921 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Insulin signaling pathway -0.449565217 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Insulin signaling pathway 0 -0.441699605 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Insulin signaling pathway -0.633043478 -0.559288538 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Insulin signaling pathway 0 -0.730237154 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Insulin signaling pathway 0 -0.722332016 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Insulin signaling pathway -0.426956522 -0.531620553 -0.474646075 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Insulin signaling pathway 0 -0.602766798 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Insulin signaling pathway 0 0.531620553 0.432689833 kegg kegg NA NA no no no no no no Notch signaling pathway Insulin signaling pathway 0 -0.457509881 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Insulin signaling pathway 0.496521739 0.460474308 0.598712999 kegg kegg NA NA no no no no no no Olfactory transduction Insulin signaling pathway 0 -0.437747036 0 kegg kegg NA NA no no no no no no One carbon pool by folate Insulin signaling pathway 0.409565217 0 0.436036036 kegg kegg NA NA no no no no no no Oocyte meiosis Insulin signaling pathway 0.528695652 0.726284585 0.450707851 kegg kegg NA NA no no no no no no Osteoclast differentiation Insulin signaling pathway 0 -0.643280632 -0.435521236 kegg kegg NA NA no no no no no no Other glycan degradation Insulin signaling pathway 0 -0.555335968 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Insulin signaling pathway 0.532173913 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Insulin signaling pathway 0 0.677865613 0 kegg kegg NA NA no no no no no no p53 signaling pathway Insulin signaling pathway 0.457391304 0 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Insulin signaling pathway 0 -0.699604743 0 kegg kegg NA NA no no dn no no no Parabacteroides Insulin signaling pathway 0 0 -0.414183668 Genus kegg 4.19E-05 NA no up up no no no Pentose and glucuronate interconversions Insulin signaling pathway 0 0.625494071 0.553153153 kegg kegg NA NA no no no no no no Pentose phosphate pathway Insulin signaling pathway -0.470434783 -0.509881423 0 kegg kegg NA NA no no no no no no Peroxisome Insulin signaling pathway 0 -0.581027668 0 kegg kegg NA NA no no no no no no Phagosome Insulin signaling pathway -0.630434783 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Insulin signaling pathway -0.42 -0.829051383 -0.618018018 kegg kegg NA NA no up up no no no Phototransduction Insulin signaling pathway 0 0.609683794 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Insulin signaling pathway 0.657391304 0.574110672 0.894208494 yes kegg kegg NA NA no up up no no no Platelet activation Insulin signaling pathway -0.535652174 0 -0.41981982 kegg kegg NA NA no no no no no no PPAR signaling pathway Insulin signaling pathway 0 -0.477272727 0 kegg kegg NA NA no no no no no no Propanoate metabolism Insulin signaling pathway 0 0.837944664 0.743114543 kegg kegg NA NA no no no no no no Proteasome Insulin signaling pathway 0.45826087 0.590909091 0.553410553 kegg kegg NA NA no no no no no no Protein export Insulin signaling pathway 0.68 0.793478261 0.641441441 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Insulin signaling pathway 0.473913043 0.670948617 0.512998713 kegg kegg NA NA no no no no no no Pyruvate metabolism Insulin signaling pathway 0.407826087 0.859683794 0.616216216 kegg kegg NA NA no no no no no no Rap1 signaling pathway Insulin signaling pathway -0.549565217 0 -0.426512227 kegg kegg NA NA no no no no no no Ras signaling pathway Insulin signaling pathway 0 0.536561265 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Insulin signaling pathway 0 0.458498024 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Insulin signaling pathway 0 -0.46541502 0 kegg kegg NA NA no no no no no no Retinol metabolism Insulin signaling pathway 0 0 0.42007722 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Insulin signaling pathway 0 0.714426877 0 kegg kegg NA NA no no up no no no Ribosome Insulin signaling pathway 0.703478261 0.896245059 0.77992278 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Insulin signaling pathway 0.695652174 0.416007905 0.589446589 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Insulin signaling pathway 0 -0.634387352 0 kegg kegg NA NA no no no no no no RNA degradation Insulin signaling pathway 0.566086957 0.710474308 0.612870013 kegg kegg NA NA no no no no no no RNA polymerase Insulin signaling pathway 0.640869565 0.586956522 0.631917632 kegg kegg NA NA no no no no no no RNA transport Insulin signaling pathway 0.562608696 0.935770751 0.728185328 kegg kegg NA NA no no no no no no Selenocompound metabolism Insulin signaling pathway 0.553913043 0 0 kegg kegg NA NA no no no no no no Serotonergic synapse Insulin signaling pathway 0 0 -0.567052767 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Insulin signaling pathway 0 -0.641304348 0 kegg kegg NA NA no no no no no no Spliceosome Insulin signaling pathway 0.652173913 0 0.537709138 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Insulin signaling pathway 0 -0.760869565 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Insulin signaling pathway 0.415652174 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Insulin signaling pathway 0 -0.491106719 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Insulin signaling pathway 0.416521739 0.420948617 0.482110682 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Insulin signaling pathway 0 -0.515810277 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Insulin signaling pathway 0.53826087 0 0.487516088 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Insulin signaling pathway 0 0.776679842 0 kegg kegg NA NA no no no no no no Thermogenesis Insulin signaling pathway 0 0.748023715 0 kegg kegg NA NA no no no no no no Thiamine metabolism Insulin signaling pathway 0 0.785573123 0 kegg kegg NA NA no no no no no no TNF signaling pathway Insulin signaling pathway 0 -0.596837945 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Insulin signaling pathway 0 -0.62055336 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Insulin signaling pathway 0 0.424901186 0.561389961 kegg kegg NA NA no up no no no no Tyrosine metabolism Insulin signaling pathway 0 0.511857708 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Insulin signaling pathway 0 0 0.501158301 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Insulin signaling pathway 0.45826087 0.580039526 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Insulin signaling pathway 0 0.461462451 0.566537967 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Insulin signaling pathway 0.607826087 0.515810277 0.438867439 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Insulin signaling pathway 0 0.52173913 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Insulin signaling pathway 0 0.615612648 0 kegg kegg NA NA no no no no no no ABC transporters Intestinal immune network for IgA production 0 -0.550395257 0 kegg kegg NA NA no up up no no no Adherens junction Intestinal immune network for IgA production 0 0.440711462 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Intestinal immune network for IgA production 0 -0.5 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Intestinal immune network for IgA production -0.495652174 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Intestinal immune network for IgA production -0.434782609 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Intestinal immune network for IgA production 0 -0.485177866 0 kegg kegg NA NA no no no no no no Axon guidance Intestinal immune network for IgA production 0 0.669960474 0 kegg kegg NA NA no up up no no no Bifidobacterium Intestinal immune network for IgA production -0.407914774 0 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Calcium signaling pathway Intestinal immune network for IgA production 0.442608696 0 0 kegg kegg NA NA no up up no no no Carbon metabolism Intestinal immune network for IgA production 0 0.466403162 0 kegg kegg NA NA no no no no no no Clostridium Intestinal immune network for IgA production 0 0.480876184 0 Genus kegg 0.925 NA no no no no no no Cysteine and methionine metabolism Intestinal immune network for IgA production -0.408695652 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Intestinal immune network for IgA production 0.488695652 0 0 kegg kegg NA NA no no no no no no Focal adhesion Intestinal immune network for IgA production 0 0.43972332 0 kegg kegg NA NA no up up no no no Folate biosynthesis Intestinal immune network for IgA production -0.507826087 0.4743083 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Intestinal immune network for IgA production 0 -0.425889328 0 kegg kegg NA NA no no no no no no Fusobacterium Intestinal immune network for IgA production 0 -0.415694842 0 Genus kegg 0.628 NA no no no no no no Glycerolipid metabolism Intestinal immune network for IgA production 0 -0.42687747 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Intestinal immune network for IgA production 0 -0.562252964 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Intestinal immune network for IgA production 0 0.475296443 0.401544402 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Intestinal immune network for IgA production 0 -0.579051383 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Intestinal immune network for IgA production 0 0.584980237 0.622908623 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Intestinal immune network for IgA production 0 0.483201581 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Intestinal immune network for IgA production 0 0.43083004 0 kegg kegg NA NA no no no no no no Homologous recombination Intestinal immune network for IgA production 0 -0.447628458 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Intestinal immune network for IgA production 0 -0.446640316 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Intestinal immune network for IgA production 0 -0.416996047 0 kegg kegg NA NA no no no no no no Lachnospira Intestinal immune network for IgA production -0.433043478 0 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Leukocyte transendothelial migration Intestinal immune network for IgA production 0 0.606719368 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Intestinal immune network for IgA production 0 -0.546442688 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Intestinal immune network for IgA production -0.430434783 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Intestinal immune network for IgA production -0.580869565 0 0 kegg kegg NA NA up up up no no no p53 signaling pathway Intestinal immune network for IgA production 0 -0.556324111 0 kegg kegg NA NA no no no no no no Propanoate metabolism Intestinal immune network for IgA production -0.475652174 0 0 kegg kegg NA NA no no no no no no Protein export Intestinal immune network for IgA production 0 0.415019763 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Intestinal immune network for IgA production 0 -0.471343874 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Intestinal immune network for IgA production 0 0.479249012 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Intestinal immune network for IgA production 0 0.451581028 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Intestinal immune network for IgA production -0.539130435 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Intestinal immune network for IgA production -0.428695652 0 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Intestinal immune network for IgA production 0 -0.450592885 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Intestinal immune network for IgA production 0 0.432806324 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Intestinal immune network for IgA production 0.517391304 0 0.675675676 kegg kegg NA NA no no no no no no Th17 cell differentiation Intestinal immune network for IgA production 0.58173913 0 0.712483912 kegg kegg NA NA no no no no no no Thiamine metabolism Intestinal immune network for IgA production -0.568695652 0 0 kegg kegg NA NA no no no no no no Tight junction Intestinal immune network for IgA production 0 0.429841897 0 kegg kegg NA NA no no no no no no 14:0/16:0-PC+blood IP-10 0 0 0.763909774 serum_phospholipids serum_cytokines 0.0358 0.394 no up no no no no 14:0/18:2-PC+blood IP-10 0 0 0.630075188 serum_phospholipids serum_cytokines 0.102 0.394 no up no no no no 14:0+blood IP-10 0 0 0.469172932 yes serum_fattyacid serum_cytokines 0.00572 0.394 up no dn no no no 16:0/16:1-PC+blood IP-10 0 0.514285714 0.744360902 serum_phospholipids serum_cytokines 0.00283 0.394 up up no no no no 16:0/18:2-PI+blood IP-10 0 0 0.660150376 serum_phospholipids serum_cytokines 0.269 0.394 no no no no no no 16:0/18:3-PC+blood IP-10 0 0 0.607518797 serum_phospholipids serum_cytokines 0.00216 0.394 no up up no no no 16:0/20:3-PC+blood IP-10 0 0.535714286 0 serum_phospholipids serum_cytokines 5.43E-06 0.394 no up up no no no 16:0/20:4-PI+blood IP-10 0 0 0.688721805 serum_phospholipids serum_cytokines 0.558 0.394 no no no no no no 16:0/22:6-PE+blood IP-10 0 0 0.44962406 serum_phospholipids serum_cytokines 0.000934 0.394 up up no no no no 18:0/18:0-PC+blood IP-10 0 0.767857143 0 serum_phospholipids serum_cytokines 0.426 0.394 no no no no no no 18:0/18:1-PC+blood IP-10 0 0.771428571 0 serum_phospholipids serum_cytokines 0.393 0.394 no no no no no no 18:0/20:2-PC+blood IP-10 0 0.757142857 0 serum_phospholipids serum_cytokines 0.733 0.394 no no no no no no 18:0/20:3-PC+blood IP-10 0 0.760714286 0 serum_phospholipids serum_cytokines 0.0682 0.394 no up no no no no 18:0/20:5-PC+blood IP-10 0 0 -0.54887218 serum_phospholipids serum_cytokines 0.17 0.394 no no no no no no 18:1-LPC+blood IP-10 0 0 -0.446616541 serum_phospholipids serum_cytokines 0.179 0.394 no no no no no no 18:1/20:4-PC+blood IP-10 -0.636363636 0 -0.461654135 serum_phospholipids serum_cytokines 0.582 0.394 no no no no no no 18:3n6+blood IP-10 0 0 0.452631579 serum_fattyacid serum_cytokines 0.0463 0.394 up no dn no no no 20:2/18:0-PC+blood IP-10 0 0.771428571 0 serum_phospholipids serum_cytokines 0.0427 0.394 no up no no no no 20:3n6+blood IP-10 0 0.575 0 serum_fattyacid serum_cytokines 0.0884 0.394 up no no no no no 20:4/18:0-PE+blood IP-10 0 -0.596428571 0 serum_phospholipids serum_cytokines 0.000755 0.394 up up no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool IP-10 0 0 0.507352941 stool_cometabolism serum_cytokines 0.33 0.394 no no no no no no AA+blood IP-10 0 -0.582142857 -0.520300752 serum_ARA serum_cytokines 0.212 0.394 no no no no no no Alcoholism IP-10 0 -0.566917293 0 kegg serum_cytokines NA 0.394 no no no no no no Aldosterone synthesis and secretion IP-10 0 0 0.499726327 kegg serum_cytokines NA 0.394 no up up no no no Alzheimer disease IP-10 -0.653846154 0 0 kegg serum_cytokines NA 0.394 no no no no no no Amphetamine addiction IP-10 0 0 0.54077723 kegg serum_cytokines NA 0.394 no no no no no no Amyotrophic lateral sclerosis IP-10 -0.659340659 0 0 kegg serum_cytokines NA 0.394 no no no no no no Bacterial invasion of epithelial cells IP-10 0 0 -0.442802408 kegg serum_cytokines NA 0.394 no no no no no no Betaine+blood IP-10 0 0 -0.645112782 serum_choline serum_cytokines 0.857 0.394 no no no no no no Biosynthesis of amino acids IP-10 0 0 -0.522714833 kegg serum_cytokines NA 0.394 no no no no no no Butyricicoccus IP-10 0 0 -0.411206615 butyrate-producing Genus serum_cytokines 0.852 0.394 no no no no no no Carbon metabolism IP-10 0 0 -0.690202518 kegg serum_cytokines NA 0.394 no no no no no no Cardiac muscle contraction IP-10 -0.653846154 0 0 kegg serum_cytokines NA 0.394 no no up no no no CDCA+stool IP-10 0 0.629370629 0 stool_bileacids serum_cytokines 0.663 0.394 no no no no no no Collinsella IP-10 0.613480635 0 0 Genus serum_cytokines 0.128 0.394 no no no no no no d18:0-24:1-SM+blood IP-10 0 0.596428571 0 serum_phospholipids serum_cytokines 0.0609 0.394 no dn dn no no no d18:1-22:0-SM+blood IP-10 0 0.607142857 0 serum_phospholipids serum_cytokines 0.522 0.394 no no no no no no Diabetic cardiomyopathy IP-10 -0.626373626 0 0 kegg serum_cytokines NA 0.394 no no no no no no Dopaminergic synapse IP-10 0 0 0.603174603 kegg serum_cytokines NA 0.394 no up no no no no Faecalibacterium IP-10 -0.554945055 0 0 butyrate-producing Genus serum_cytokines 0.0039 0.394 no dn dn no no no Fc gamma R-mediated phagocytosis IP-10 0 0 -0.465790914 kegg serum_cytokines NA 0.394 no no no no no no FGF basic IP-10 -0.587912088 0 0 serum_cytokines serum_cytokines 0.65 0.394 no no no no no no GDCA+blood IP-10 0 -0.6 0 serum_bileacids serum_cytokines 0.632 0.394 no no no no no no GDCA+stool IP-10 0 0.584939601 0 stool_bileacids serum_cytokines 0.656 0.394 no no no no no no Glucagon signaling pathway IP-10 0 0 0.409961686 kegg serum_cytokines NA 0.394 no no no no no no Glycolysis / Gluconeogenesis IP-10 0 0 -0.432950192 kegg serum_cytokines NA 0.394 no no no no no no GnRH signaling pathway IP-10 0 0 0.46031746 kegg serum_cytokines NA 0.394 no no no no no no Homovanillic acid+urine IP-10 0 -0.511764706 0 urine_cometabolism serum_cytokines 0.45 0.394 no no no no no no Huntington disease IP-10 -0.648351648 0 0 kegg serum_cytokines NA 0.394 no no no no no no IFN-g IP-10 -0.554945055 -0.664935065 0 serum_cytokines serum_cytokines 0.825 0.394 no no no no no no IL-2 IP-10 0 -0.51038961 -0.435372636 serum_cytokines serum_cytokines 0.522 0.394 no no no no no no IL-6 IP-10 0 -0.506493506 -0.537708565 serum_cytokines serum_cytokines 0.52 0.394 no no no no no no Inflammatory mediator regulation of TRP channels IP-10 0 0 0.422550629 kegg serum_cytokines NA 0.394 no no no no no no Insulin resistance IP-10 -0.71978022 0 0 kegg serum_cytokines NA 0.394 no no no no no no iso-DCA+blood IP-10 0 -0.585714286 0 serum_bileacids serum_cytokines 0.38 0.394 no no no no no no L-2-Aminobutyric acid+blood IP-10 0 0 -0.52481203 yes serum_aminoacids serum_cytokines 0.000328 0.394 up up no no no no L-Citrulline+blood IP-10 0 0 -0.595488722 serum_aminoacids serum_cytokines 0.534 0.394 no no no no no no L-Glutamine+blood IP-10 0 0 -0.554887218 serum_aminoacids serum_cytokines 0.639 0.394 no no no no no no L-Homocystine+blood IP-10 -0.793939394 0 0 serum_aminoacids serum_cytokines 0.197 0.394 no no no no no no L-Ornithine+blood IP-10 0 0 -0.529323308 serum_aminoacids serum_cytokines 0.175 0.394 no no no no no no L-Tryptophan+blood IP-10 0 0 -0.455639098 serum_aminoacids serum_cytokines 0.164 0.394 no no no no no no L-Tryptophan+urine IP-10 -0.745454545 0 0 urine_cometabolism serum_cytokines 0.226 0.394 no no no no no no L-Tyrosine+blood IP-10 0 0.564285714 0 yes serum_aminoacids serum_cytokines 0.00913 0.394 up up no no no no Leukocyte transendothelial migration IP-10 0 0 -0.524356869 kegg serum_cytokines NA 0.394 no no no no no no Lysosome IP-10 0 0 -0.458128079 kegg serum_cytokines NA 0.394 no no no no no no Melanogenesis IP-10 0 0 0.471811713 kegg serum_cytokines NA 0.394 no no no no no no MicroRNAs in cancer IP-10 -0.626373626 0 0 kegg serum_cytokines NA 0.394 no no no no no no Neuroactive ligand-receptor interaction IP-10 0 0 -0.564860427 kegg serum_cytokines NA 0.394 up up up no no no Neurotrophin signaling pathway IP-10 -0.554945055 0 0 kegg serum_cytokines NA 0.394 no no no no no no Neutrophil extracellular trap formation IP-10 0 0 -0.535851122 kegg serum_cytokines NA 0.394 no no no no no no Non-alcoholic fatty liver disease IP-10 -0.631868132 0 0 kegg serum_cytokines NA 0.394 no no no no no no Oxidative phosphorylation IP-10 -0.648351648 0 0 kegg serum_cytokines NA 0.394 no no no no no no p53 signaling pathway IP-10 0 0 0.45320197 kegg serum_cytokines NA 0.394 no no no no no no Paraprevotella IP-10 0 0.501933551 0 Genus serum_cytokines 0.118 0.394 no no no no no no "Parathyroid hormone synthesis, secretion and action" IP-10 -0.554945055 0 0 kegg serum_cytokines NA 0.394 no no no no no no Pathogenic Escherichia coli infection IP-10 0 0 -0.616858238 kegg serum_cytokines NA 0.394 no no no no no no Pathways in cancer IP-10 -0.571428571 0 0.446086481 kegg serum_cytokines NA 0.394 no no no no no no Peroxisome IP-10 0 0 -0.403393541 kegg serum_cytokines NA 0.394 no no no no no no Porphyrin and chlorophyll metabolism IP-10 0.582417582 0 0 kegg serum_cytokines NA 0.394 no no no no no no Progesterone-mediated oocyte maturation IP-10 -0.642857143 0 0 kegg serum_cytokines NA 0.394 no no no no no no Prostate cancer IP-10 -0.593406593 0 0 kegg serum_cytokines NA 0.394 no no no no no no Rheumatoid arthritis IP-10 0 0 -0.51833607 kegg serum_cytokines NA 0.394 no no no no no no Roseburia IP-10 0 0.488470308 0 butyrate-producing Genus serum_cytokines 0.495 0.394 no no no no no no Ruminococcus IP-10 0 0.537662338 0 acetate-producing Genus serum_cytokines 0.335 0.394 no no no no no no Salmonella infection IP-10 0 0 -0.646414888 kegg serum_cytokines NA 0.394 no no no no no no Sarcina IP-10 0 0.509647191 0 Genus serum_cytokines 0.0703 0.394 no no no no no no Sarcosine+blood IP-10 0 0 0.587969925 serum_choline serum_cytokines 5.06E-05 0.394 up up no no no no Signaling pathways regulating pluripotency of stem cells IP-10 -0.648351648 0 0 kegg serum_cytokines NA 0.394 no no no no no no Small cell lung cancer IP-10 0 0 0.473453749 kegg serum_cytokines NA 0.394 no no up no no no Staphylococcus aureus infection IP-10 0 0 -0.546250684 kegg serum_cytokines NA 0.394 up no no no no no Systemic lupus erythematosus IP-10 0 0 -0.521620142 kegg serum_cytokines NA 0.394 no no no no no no TDCA+blood IP-10 0 -0.604367223 0 yes serum_bileacids serum_cytokines 0.155 0.394 no up no no no no Thermogenesis IP-10 -0.554945055 0 0 kegg serum_cytokines NA 0.394 no no no no no no Thyroid cancer IP-10 0 0 0.499178982 kegg serum_cytokines NA 0.394 no no no no no no Tight junction IP-10 0 0 -0.443349754 kegg serum_cytokines NA 0.394 no no no no no no Tuberculosis IP-10 0 0 -0.555555556 kegg serum_cytokines NA 0.394 no no dn no no no TXB2+blood IP-10 0.650458932 0 0 yes serum_ARA serum_cytokines 0.0644 0.394 dn no no no no no Valine+blood IP-10 0 0 -0.49924812 yes serum_aminoacids serum_cytokines 1.22E-06 0.394 up up no no no no 12-ketoDCA+blood iso-DCA+blood -0.48720945 0 0 serum_bileacids serum_bileacids 0.517 0.38 no no no no no no 13-HODE+blood iso-DCA+blood 0.455639098 0.482843137 0 serum_ARA serum_bileacids 0.32 0.38 no no no no no no 15-HETE+blood iso-DCA+blood 0 -0.498159899 0 serum_ARA serum_bileacids 0.819 0.38 no no no no no no 16:0-LPE+blood iso-DCA+blood -0.631578947 0 0 serum_phospholipids serum_bileacids 0.0711 0.38 up up no no no no 16:0/14:0-PC+blood iso-DCA+blood 0.556390977 0 0.549401709 serum_phospholipids serum_bileacids 0.0206 0.38 no up up no no no 16:0/16:0-PC+blood iso-DCA+blood 0.554887218 0 0.402393162 serum_phospholipids serum_bileacids 0.00079 0.38 no up up no no no 16:0/16:1-PI+blood iso-DCA+blood -0.589473684 0 0 serum_phospholipids serum_bileacids 0.262 0.38 no no no no no no 16:0/18:0-PS+blood iso-DCA+blood 0 0 -0.465982906 serum_phospholipids serum_bileacids 0.377 0.38 no no no no no no 16:0/18:1-PC+blood iso-DCA+blood 0.518796992 0 0 serum_phospholipids serum_bileacids 6.15E-07 0.38 up up up no no no 16:0/18:1-PE+blood iso-DCA+blood -0.44962406 0 0 serum_phospholipids serum_bileacids 0.000107 0.38 up up no no no no 16:0/18:2-PC+blood iso-DCA+blood 0.559398496 0 0.561709402 serum_phospholipids serum_bileacids 3.24E-06 0.38 no up up no no no 16:0/20:3-PC+blood iso-DCA+blood 0.798496241 0 0.410598291 serum_phospholipids serum_bileacids 5.43E-06 0.38 no up up no no no 16:0/20:4-PC+blood iso-DCA+blood 0.479699248 0 0 serum_phospholipids serum_bileacids 0.0262 0.38 no up no no no no 16:0/20:4-PE+blood iso-DCA+blood -0.490225564 0 0 serum_phospholipids serum_bileacids 0.00139 0.38 up up no no no no 16:0/20:4-PI+blood iso-DCA+blood -0.467669173 -0.610294118 0 serum_phospholipids serum_bileacids 0.558 0.38 no no no no no no 16:1/16:0-PC+blood iso-DCA+blood 0.517293233 0 0 serum_phospholipids serum_bileacids 0.0215 0.38 no up up no no no 16:1/16:1-PC+blood iso-DCA+blood 0.544360902 0 0 serum_phospholipids serum_bileacids 0.0177 0.38 no no up no no no 16:1/18:1-PG+blood iso-DCA+blood 0 0 -0.414017094 serum_phospholipids serum_bileacids 3.21E-05 0.38 no up up no no no 16:1/18:2-PG+blood iso-DCA+blood 0.658646617 0 0 serum_phospholipids serum_bileacids 1.40E-08 0.38 no up up no no no 18:0-LPE+blood iso-DCA+blood -0.473684211 0 0 serum_phospholipids serum_bileacids 0.491 0.38 no no no no no no 18:0/16:0-PC+blood iso-DCA+blood 0.472180451 0 0 serum_phospholipids serum_bileacids 9.64E-07 0.38 up up up no no no 18:0/18:0-PE+blood iso-DCA+blood -0.593984962 0 -0.413333333 serum_phospholipids serum_bileacids 0.00896 0.38 up up no no no no 18:0/18:0-PS+blood iso-DCA+blood 0 0 -0.417435897 serum_phospholipids serum_bileacids 0.00617 0.38 no up no no no no 18:0/18:1-PE+blood iso-DCA+blood -0.618045113 0 0 serum_phospholipids serum_bileacids 0.00716 0.38 up up no no no no 18:0/18:1-PG+blood iso-DCA+blood -0.472180451 0 0 serum_phospholipids serum_bileacids 0.000842 0.38 no up no no no no 18:0/18:2-PC+blood iso-DCA+blood 0.693233083 0 0.535042735 serum_phospholipids serum_bileacids 1.74E-06 0.38 no up up no no no 18:0/20:4-PC+blood iso-DCA+blood 0.460150376 0 0 serum_phospholipids serum_bileacids 0.454 0.38 no no no no no no 18:0+blood iso-DCA+blood 0 0 0.483076923 serum_fattyacid serum_bileacids 0.344 0.38 no no no no no no 18:1/16:0-PC+blood iso-DCA+blood 0.512781955 0 0.540512821 serum_phospholipids serum_bileacids 2.43E-05 0.38 no up up no no no 18:1/16:0-PE+blood iso-DCA+blood -0.508270677 0 0 serum_phospholipids serum_bileacids 0.000182 0.38 up up no no no no 18:1/16:0-PI+blood iso-DCA+blood -0.44962406 0 0 serum_phospholipids serum_bileacids 0.793 0.38 no no no no no no 18:1/16:1-PE+blood iso-DCA+blood -0.49924812 0 0 serum_phospholipids serum_bileacids 0.000184 0.38 up up no no no no 18:1/18:0-PC+blood iso-DCA+blood 0.703759398 0 0.537094017 serum_phospholipids serum_bileacids 1.83E-06 0.38 no up up no no no 18:1/18:0-PS+blood iso-DCA+blood 0 -0.492647059 0 serum_phospholipids serum_bileacids 0.193 0.38 no no no no no no 18:1/18:1-PC+blood iso-DCA+blood 0.756390977 0 0 serum_phospholipids serum_bileacids 1.34E-05 0.38 no up up no no no 18:1/18:2-PG+blood iso-DCA+blood 0.669172932 0 0 serum_phospholipids serum_bileacids 5.58E-07 0.38 no up up no no no 18:1/20:3-PC+blood iso-DCA+blood 0.633082707 0 0 serum_phospholipids serum_bileacids 0.00872 0.38 no up up no no no 18:2-LPA+blood iso-DCA+blood 0.521804511 0 0 serum_phospholipids serum_bileacids 0.00684 0.38 dn no up no no no 18:2/16:0-PC+blood iso-DCA+blood 0.787969925 0 0.411282051 serum_phospholipids serum_bileacids 8.67E-05 0.38 no up up no no no 18:2/18:1-PC+blood iso-DCA+blood 0.527819549 0 0 serum_phospholipids serum_bileacids 2.30E-05 0.38 dn up up no no no 18:2/18:2-PC+blood iso-DCA+blood 0.47518797 0 0 serum_phospholipids serum_bileacids 1.98E-05 0.38 dn up up no no no 18:2n6c+blood iso-DCA+blood 0 0 0.425641026 serum_fattyacid serum_bileacids 0.15 0.38 no no no no no no 18:3n3+blood iso-DCA+blood 0 0 0.444102564 serum_fattyacid serum_bileacids 0.291 0.38 no no no no no no 20:1-LPA+blood iso-DCA+blood 0.496240602 0 0 serum_phospholipids serum_bileacids 0.0187 0.38 dn dn no no no no 20:2-LPC+blood iso-DCA+blood 0.664661654 0 0.535726496 serum_phospholipids serum_bileacids 0.119 0.38 no no up no no no 20:2+blood iso-DCA+blood 0.560902256 0 0.404444444 serum_fattyacid serum_bileacids 0.478 0.38 no no no no no no 20:3/16:0-PC+blood iso-DCA+blood 0.49924812 0 0.414700855 serum_phospholipids serum_bileacids 0.00405 0.38 no up up no no no AA+blood iso-DCA+blood 0.455639098 0 0 serum_ARA serum_bileacids 0.212 0.38 no no no no no no Acute myeloid leukemia iso-DCA+blood 0 0 0.436923077 kegg serum_bileacids NA 0.38 no no no no no no Adherens junction iso-DCA+blood 0 0 -0.48 kegg serum_bileacids NA 0.38 no no no no no no Adrenergic signaling in cardiomyocytes iso-DCA+blood 0 0 -0.414615385 kegg serum_bileacids NA 0.38 no no up no no no Alzheimer disease iso-DCA+blood 0 0 -0.491538462 kegg serum_bileacids NA 0.38 no no no no no no Amphetamine addiction iso-DCA+blood 0 0 -0.406153846 kegg serum_bileacids NA 0.38 no no no no no no Amyotrophic lateral sclerosis iso-DCA+blood 0 0 -0.529230769 kegg serum_bileacids NA 0.38 no no no no no no Arginine and proline metabolism iso-DCA+blood 0 0 0.426923077 kegg serum_bileacids NA 0.38 no up no no no no Arrhythmogenic right ventricular cardiomyopathy iso-DCA+blood 0 0 -0.463076923 kegg serum_bileacids NA 0.38 no up up no no no B cell receptor signaling pathway iso-DCA+blood 0 0 0.423846154 kegg serum_bileacids NA 0.38 no no no no no no Butyricimonas iso-DCA+blood 0 -0.538411071 0 butyrate-producing Genus serum_bileacids 0.17 0.38 no no no no no no Cardiac muscle contraction iso-DCA+blood 0 0 -0.536153846 kegg serum_bileacids NA 0.38 no no up no no no Choline+blood iso-DCA+blood 0 0 0.483076923 serum_choline serum_bileacids 0.0395 0.38 no up no no no no Chronic myeloid leukemia iso-DCA+blood 0 0 0.462307692 kegg serum_bileacids NA 0.38 no no no no no no Creatinine+blood iso-DCA+blood 0 0.536764706 0 serum_choline serum_bileacids 0.437 0.38 no no no no no no Cysteine+blood iso-DCA+blood 0.569924812 0 0.565811966 yes serum_aminoacids serum_bileacids 1.81E-07 0.38 dn up up no no no d18:1-14:0-SM+blood iso-DCA+blood 0 0 -0.515897436 serum_phospholipids serum_bileacids 0.94 0.38 no no no no no no d18:1-18:0-SM+blood iso-DCA+blood 0.476691729 0 0 serum_phospholipids serum_bileacids 0.97 0.38 no no no no no no d18:1-20:1-SM+blood iso-DCA+blood 0.463157895 0 0 serum_phospholipids serum_bileacids 0.0992 0.38 no no no no no no Diabetic cardiomyopathy iso-DCA+blood 0 0 -0.507692308 kegg serum_bileacids NA 0.38 no no no no no no Dilated cardiomyopathy iso-DCA+blood 0 0 -0.527692308 kegg serum_bileacids NA 0.38 no up up no no no Estrogen signaling pathway iso-DCA+blood 0 0 -0.423846154 kegg serum_bileacids NA 0.38 no no no no no no Focal adhesion iso-DCA+blood 0 0 -0.546153846 kegg serum_bileacids NA 0.38 no up up no no no Gastric acid secretion iso-DCA+blood 0 0 -0.482307692 kegg serum_bileacids NA 0.38 no no no no no no GCA+blood iso-DCA+blood -0.461654135 0 0 yes serum_bileacids serum_bileacids 0.16 0.38 no no no no no no GCDCA+blood iso-DCA+blood -0.541353383 0 0 serum_bileacids serum_bileacids 0.31 0.38 no no no no no no GUDCA+blood iso-DCA+blood -0.464661654 0 0 serum_bileacids serum_bileacids 0.0766 0.38 no no dn no no no Hippo signaling pathway iso-DCA+blood 0 0 -0.516923077 kegg serum_bileacids NA 0.38 no no no no no no Huntington disease iso-DCA+blood 0 0 -0.429230769 kegg serum_bileacids NA 0.38 no no no no no no Hypertrophic cardiomyopathy iso-DCA+blood 0 0 -0.423846154 kegg serum_bileacids NA 0.38 no up up no no no Hypotaurine+blood iso-DCA+blood 0 0.590686275 0 serum_aminoacids serum_bileacids 0.933 0.38 no no no no no no IL-17 signaling pathway iso-DCA+blood 0 0 0.430769231 kegg serum_bileacids NA 0.38 no no no no no no Inflammatory mediator regulation of TRP channels iso-DCA+blood 0 0 -0.446153846 kegg serum_bileacids NA 0.38 no no no no no no Melanogenesis iso-DCA+blood 0 0 -0.436153846 kegg serum_bileacids NA 0.38 no no no no no no NF-kappa B signaling pathway iso-DCA+blood 0 0 0.486923077 kegg serum_bileacids NA 0.38 no no no no no no Non-alcoholic fatty liver disease iso-DCA+blood 0 0 -0.539230769 kegg serum_bileacids NA 0.38 no no no no no no Oocyte meiosis iso-DCA+blood 0 0 -0.404615385 kegg serum_bileacids NA 0.38 no no no no no no Oscillospira iso-DCA+blood 0 0 0.42017094 LPS-producing Genus serum_bileacids 0.62 0.38 no no no no no no Oxidative phosphorylation iso-DCA+blood 0 0 -0.474615385 kegg serum_bileacids NA 0.38 no no no no no no Prevotella iso-DCA+blood -0.455720133 0 0 acetate-producing Genus serum_bileacids 0.287 0.38 no no no no no no Prion disease iso-DCA+blood 0 0 -0.523846154 kegg serum_bileacids NA 0.38 no no no no no no TCA+stool iso-DCA+blood -0.558459951 0 0 stool_bileacids serum_bileacids 0.458 0.38 no no no no no no Thermogenesis iso-DCA+blood 0 0 -0.459230769 kegg serum_bileacids NA 0.38 no no no no no no Thyroid hormone signaling pathway iso-DCA+blood 0 0 -0.482307692 kegg serum_bileacids NA 0.38 no no no no no no TNF signaling pathway iso-DCA+blood 0 0 0.404615385 kegg serum_bileacids NA 0.38 no no no no no no Viral protein interaction with cytokine and cytokine receptor iso-DCA+blood 0.477192982 0 0 kegg serum_bileacids NA 0.38 no no no no no no 12-ketoDCA+stool iso-DCA+stool 0 0 0.449604743 stool_bileacids stool_bileacids 0.505 0.155 no no no no no no CA+stool iso-DCA+stool -0.558307534 0 0 stool_bileacids stool_bileacids 0.827 0.155 no no no no no no CDCA+stool iso-DCA+stool -0.60371517 0 0 stool_bileacids stool_bileacids 0.663 0.155 no no no no no no DCA+stool iso-DCA+stool 0.547987616 0 0 stool_bileacids stool_bileacids 0.195 0.155 no no no no no no GLCA+stool iso-DCA+stool 0 0 0.525101769 stool_bileacids stool_bileacids 0.617 0.155 no no no no no no HCA+stool iso-DCA+stool -0.492260062 0 0 stool_bileacids stool_bileacids 0.155 0.155 no no no no no no HDCA+stool iso-DCA+stool 0.504643963 0.657342657 0 stool_bileacids stool_bileacids 0.176 0.155 no no no no no no ¦Ø-MCA+stool iso-DCA+stool -0.524555057 0 0 stool_bileacids stool_bileacids 0.919 0.155 no no no no no no 14:0/18:0-PC+blood iso-heptanoic acid C7+blood 0 0.50245098 0.403076923 serum_phospholipids serum_mcfa 0.00289 0.00256 up up no up up no 16:0/16:0-PI+blood iso-heptanoic acid C7+blood 0 0.549019608 0 serum_phospholipids serum_mcfa 0.358 0.00256 no no no up up no 16:0/18:1-PC+blood iso-heptanoic acid C7+blood 0 0 0.629401709 serum_phospholipids serum_mcfa 6.15E-07 0.00256 up up up up up no 16:0/20:3-PC+blood iso-heptanoic acid C7+blood 0 0 0.554188034 serum_phospholipids serum_mcfa 5.43E-06 0.00256 no up up up up no 16:0+blood iso-heptanoic acid C7+blood 0 0 0.467350427 yes serum_fattyacid serum_mcfa 0.00876 0.00256 up no no up up no 18:0/16:0-PC+blood iso-heptanoic acid C7+blood 0 0 0.607521368 serum_phospholipids serum_mcfa 9.64E-07 0.00256 up up up up up no 18:0/20:3-PC+blood iso-heptanoic acid C7+blood 0 0 0.437948718 serum_phospholipids serum_mcfa 0.0682 0.00256 no up no up up no 18:0/20:3-PI+blood iso-heptanoic acid C7+blood -0.460150376 0 0 serum_phospholipids serum_mcfa 0.377 0.00256 no no no up up no 18:1/18:1-PC+blood iso-heptanoic acid C7+blood 0 0 0.58017094 serum_phospholipids serum_mcfa 1.34E-05 0.00256 no up up up up no 18:3n6+blood iso-heptanoic acid C7+blood 0.533834586 -0.519607843 0 serum_fattyacid serum_mcfa 0.0463 0.00256 up no dn up up no 2-methyl-butyric acid m-C4+blood iso-heptanoic acid C7+blood 0.606015038 0 0 serum_scfa serum_mcfa 0.262 0.00256 no no no up up no 20:1-LPE+blood iso-heptanoic acid C7+blood -0.523308271 0 0 serum_phospholipids serum_mcfa 0.465 0.00256 no no no up up no 20:2-LPC+blood iso-heptanoic acid C7+blood -0.589473684 0 0 serum_phospholipids serum_mcfa 0.119 0.00256 no no up up up no 20:2/18:0-PC+blood iso-heptanoic acid C7+blood 0 0 0.419487179 serum_phospholipids serum_mcfa 0.0427 0.00256 no up no up up no 20:3n6+blood iso-heptanoic acid C7+blood 0 0 0.439316239 serum_fattyacid serum_mcfa 0.0884 0.00256 up no no up up no 5-HETE+blood iso-heptanoic acid C7+blood 0 0.482269873 0 serum_ARA serum_mcfa 0.697 0.00256 no no no up up no 9-HODE+blood iso-heptanoic acid C7+blood -0.476691729 0 0 serum_ARA serum_mcfa 0.297 0.00256 no no no up up no AA+blood iso-heptanoic acid C7+blood 0 0 -0.427692308 serum_ARA serum_mcfa 0.212 0.00256 no no no up up no butyric acid C4+blood iso-heptanoic acid C7+blood 0.52481203 0 0 serum_scfa serum_mcfa 0.407 0.00256 no no no up up no capric acid C6+blood iso-heptanoic acid C7+blood 0 0.634803922 0 serum_scfa serum_mcfa 0.433 0.00256 no no no up up no decanoic acid C10+blood iso-heptanoic acid C7+blood 0 0 0.552136752 serum_mcfa serum_mcfa 6.64E-11 0.00256 dn dn no up up no DPA+blood iso-heptanoic acid C7+blood 0 0 -0.417435897 serum_ARA serum_mcfa 0.519 0.00256 no no no up up no heptanoic acid C7+blood iso-heptanoic acid C7+blood 0.473684211 0 0 serum_mcfa serum_mcfa 8.27E-11 0.00256 dn dn no up up no 12-ketoDCA+blood iso-LCA+blood 0.501033597 0.863148791 0 serum_bileacids serum_bileacids 0.517 0.507 no no no no no no "12,13-EPOME+blood" iso-LCA+blood -0.503669365 0 0 serum_ARA serum_bileacids 0.901 0.507 no no no no no no 14:0/18:2-PC+blood iso-LCA+blood 0 0 -0.406237136 serum_phospholipids serum_bileacids 0.102 0.507 no up no no no no 14:0/20:4-PC+blood iso-LCA+blood 0 0 -0.442919452 serum_phospholipids serum_bileacids 0.486 0.507 no no no no no no 16:0/18:0-PS+blood iso-LCA+blood 0 -0.499012052 0 serum_phospholipids serum_bileacids 0.377 0.507 no no no no no no 18:0-LPA+blood iso-LCA+blood 0 -0.501879937 0 serum_phospholipids serum_bileacids 0.0725 0.507 no dn no no no no 18:0/18:0-PS+blood iso-LCA+blood 0 -0.507615708 0 serum_phospholipids serum_bileacids 0.00617 0.507 no up no no no no 18:0/20:3-PC+blood iso-LCA+blood -0.520578494 0 0 serum_phospholipids serum_bileacids 0.0682 0.507 no up no no no no 18:0/20:3-PI+blood iso-LCA+blood 0 -0.493276281 0 serum_phospholipids serum_bileacids 0.377 0.507 no no no no no no 18:0/22:6-PE+blood iso-LCA+blood 0 -0.501879937 0 serum_phospholipids serum_bileacids 0.00022 0.507 up up no no no no 18:0/22:6-PI+blood iso-LCA+blood -0.55753314 -0.613727466 0 serum_phospholipids serum_bileacids 0.425 0.507 no no no no no no 18:2/20:4-PC+blood iso-LCA+blood -0.498887723 0 0 serum_phospholipids serum_bileacids 0.0145 0.507 no no up no no no 18:3n6+blood iso-LCA+blood 0 0 -0.415993071 serum_fattyacid serum_bileacids 0.0463 0.507 up no dn no no no 20:0-LPC+blood iso-LCA+blood 0 0.673953059 0 serum_phospholipids serum_bileacids 0.199 0.507 no no no no no no 20:2/18:0-PC+blood iso-LCA+blood -0.527808751 0 0 serum_phospholipids serum_bileacids 0.0427 0.507 no up no no no no 22:6-LPC+blood iso-LCA+blood -0.518168408 0 0 serum_phospholipids serum_bileacids 0.127 0.507 no no up no no no 22:6n3+blood iso-LCA+blood -0.576010463 0 0 serum_fattyacid serum_bileacids 0.792 0.507 no no no no no no 24:1+blood iso-LCA+blood 0 -0.484672625 0 serum_fattyacid serum_bileacids 0.00582 0.507 no dn dn no no no 3-(3-Hydroxyphenyl)propanoic acid+stool iso-LCA+blood 0 0 -0.582276887 stool_cometabolism serum_bileacids 0.33 0.507 no no no no no no ACA+blood iso-LCA+blood 0.558798283 0 0 serum_bileacids serum_bileacids 0.338 0.507 no no no no no no Acetic acid+stool iso-LCA+blood 0.654659598 0 0 yes stool_scfa serum_bileacids 0.0656 0.507 dn no no no no no Akkermansia iso-LCA+blood -0.461802575 0 0 acetate-producing Genus serum_bileacids 0.23 0.507 no no no no no no Alistipes iso-LCA+blood 0.447148339 0 0 Genus serum_bileacids 0.0114 0.507 no up no no no no Allograft rejection iso-LCA+blood 0 0 -0.416840085 kegg serum_bileacids NA 0.507 no no no no no no AMPK signaling pathway iso-LCA+blood 0.606492224 0 0 kegg serum_bileacids NA 0.507 no no no no no no Apelin signaling pathway iso-LCA+blood 0.532303572 0 0 kegg serum_bileacids NA 0.507 no no no no no no Autoimmune thyroid disease iso-LCA+blood 0 0 -0.416840085 kegg serum_bileacids NA 0.507 no no no no no no Blautia iso-LCA+blood -0.674823974 -0.539162447 -0.446399408 acetate-producing Genus serum_bileacids 1.36E-05 0.507 up dn dn no no no butyric acid C4+blood iso-LCA+blood 0 0.570709186 0 serum_scfa serum_bileacids 0.407 0.507 no no no no no no CA+stool iso-LCA+blood -0.807877802 0 0 stool_bileacids serum_bileacids 0.827 0.507 no no no no no no Calcium signaling pathway iso-LCA+blood 0 0.567781459 0 kegg serum_bileacids NA 0.507 no up up no no no Carbon metabolism iso-LCA+blood 0 -0.598198323 0 kegg serum_bileacids NA 0.507 no no no no no no CDCA+stool iso-LCA+blood -0.598943887 0 -0.481701789 stool_bileacids serum_bileacids 0.663 0.507 no no no no no no Chemical carcinogenesis - receptor activation iso-LCA+blood 0 0.604957626 0 kegg serum_bileacids NA 0.507 no no no no no no Clostridium iso-LCA+blood -0.576008109 -0.509361855 0 Genus serum_bileacids 0.925 0.507 no no no no no no Coronavirus disease - COVID-19 iso-LCA+blood 0.59350921 0 0 kegg serum_bileacids NA 0.507 no no no no no no Cushing syndrome iso-LCA+blood 0 0.604957626 0 kegg serum_bileacids NA 0.507 no no up no no no d18:0-18:3-SM+blood iso-LCA+blood 0 0 -0.458528948 serum_phospholipids serum_bileacids 0.0879 0.507 no dn no no no no d18:1-14:0-SM+blood iso-LCA+blood 0 0 -0.495601501 serum_phospholipids serum_bileacids 0.94 0.507 no no no no no no d18:1-14:1-SM+blood iso-LCA+blood 0 0 -0.573258744 serum_phospholipids serum_bileacids 0.0952 0.507 no dn no no no no d18:1-22:1-SM+blood iso-LCA+blood 0 0.513351479 0 serum_phospholipids serum_bileacids 0.222 0.507 no no no no no no EGFR tyrosine kinase inhibitor resistance iso-LCA+blood 0.498918679 0 0 kegg serum_bileacids NA 0.507 no no no no no no Endocrine resistance iso-LCA+blood 0 0.596508497 0 kegg serum_bileacids NA 0.507 no no no no no no Fc gamma R-mediated phagocytosis iso-LCA+blood -0.510046977 0 0 kegg serum_bileacids NA 0.507 no no no no no no FoxO signaling pathway iso-LCA+blood 0 0 0.520181689 kegg serum_bileacids NA 0.507 no no no no no no GABAergic synapse iso-LCA+blood -0.46367907 0 0 kegg serum_bileacids NA 0.507 no up up no no no GCA+stool iso-LCA+blood -0.571086032 -0.705458603 0 stool_bileacids serum_bileacids 0.0809 0.507 no no no no no no GDCA+blood iso-LCA+blood 0 0.530558791 0.469065358 serum_bileacids serum_bileacids 0.632 0.507 no no no no no no GLCA+blood iso-LCA+blood 0.496237446 0.568342145 0.599761333 serum_bileacids serum_bileacids 0.319 0.507 no no no no no no GnRH signaling pathway iso-LCA+blood 0 0.66748118 0 kegg serum_bileacids NA 0.507 no no no no no no Graft-versus-host disease iso-LCA+blood 0 0 -0.402945415 kegg serum_bileacids NA 0.507 no no no no no no "Growth hormone synthesis, secretion and action" iso-LCA+blood 0 0.62354571 0 kegg serum_bileacids NA 0.507 no no no no no no HCA+stool iso-LCA+blood -0.55994289 0 0 stool_bileacids serum_bileacids 0.155 0.507 no no no no no no HDCA+blood iso-LCA+blood 0 0.741620475 0.402647762 serum_bileacids serum_bileacids 0.483 0.507 no no no no no no Human cytomegalovirus infection iso-LCA+blood 0 0 -0.402945415 kegg serum_bileacids NA 0.507 no no dn no no no Human immunodeficiency virus 1 infection iso-LCA+blood 0 0 -0.414234834 kegg serum_bileacids NA 0.507 no no no no no no Hypotaurine+blood iso-LCA+blood 0.461129715 0 0 serum_aminoacids serum_bileacids 0.933 0.507 no no no no no no IL-17 signaling pathway iso-LCA+blood -0.487790382 0 0 kegg serum_bileacids NA 0.507 no no no no no no Insulin signaling pathway iso-LCA+blood 0.511901693 0 0 kegg serum_bileacids NA 0.507 no no no no no no iso-LCA+stool iso-LCA+blood 0.594189072 0 0.576983461 stool_bileacids serum_bileacids 0.72 0.507 no no no no no no LCA+stool iso-LCA+blood 0 0 0.46582151 stool_bileacids serum_bileacids 0.314 0.507 no no no no no no Lipid and atherosclerosis iso-LCA+blood -0.599073359 0 0 kegg serum_bileacids NA 0.507 no no no no no no Longevity regulating pathway - multiple species iso-LCA+blood 0 -0.549193376 0 kegg serum_bileacids NA 0.507 no no no no no no Mitophagy - animal iso-LCA+blood 0.506337545 0 0 kegg serum_bileacids NA 0.507 no no no no no no mTOR signaling pathway iso-LCA+blood 0.560124317 0 0 kegg serum_bileacids NA 0.507 no no no no no no Neutrophil extracellular trap formation iso-LCA+blood -0.484080949 0 0 kegg serum_bileacids NA 0.507 no no no no no no NOD-like receptor signaling pathway iso-LCA+blood -0.476662084 0 0 kegg serum_bileacids NA 0.507 no no no no no no nutriCA+stool iso-LCA+blood -0.562728676 -0.65882927 0 stool_bileacids serum_bileacids 0.481 0.507 no no no no no no Parkinson disease iso-LCA+blood 0.504482828 0 0 kegg serum_bileacids NA 0.507 no no no no no no Pathways of neurodegeneration - multiple diseases iso-LCA+blood 0.502628112 0 0 kegg serum_bileacids NA 0.507 no no no no no no Peroxisome iso-LCA+blood -0.474807368 0 0 kegg serum_bileacids NA 0.507 no no no no no no Pertussis iso-LCA+blood -0.634312968 0 0 kegg serum_bileacids NA 0.507 no no dn no no no Prevotella iso-LCA+blood 0.527362862 0 0 Genus serum_bileacids 0.367 0.507 no no no no no no Propionic acid+stool iso-LCA+blood 0.646302241 0 0 yes stool_scfa serum_bileacids 0.0436 0.507 dn no up no no no Protein processing in endoplasmic reticulum iso-LCA+blood 0.489645098 0 0 kegg serum_bileacids NA 0.507 no no no no no no Proteoglycans in cancer iso-LCA+blood 0.504482828 0 0 kegg serum_bileacids NA 0.507 no no no no no no Renal cell carcinoma iso-LCA+blood 0.482226233 0 0 kegg serum_bileacids NA 0.507 no no no no no no Ribosome iso-LCA+blood 0.59350921 0 0 kegg serum_bileacids NA 0.507 no no no no no no Salmonella infection iso-LCA+blood 0 -0.512017209 0 kegg serum_bileacids NA 0.507 no no no no no no Shigellosis iso-LCA+blood 0.556414884 0 0 kegg serum_bileacids NA 0.507 no no no no no no total_stool_scfa+stool iso-LCA+blood 0.674160097 0 0 stool_scfa serum_bileacids 0.0534 0.507 dn no up no no no Tuberculosis iso-LCA+blood -0.482226233 0 0 kegg serum_bileacids NA 0.507 no no dn no no no Type I diabetes mellitus iso-LCA+blood 0 0 -0.408155916 kegg serum_bileacids NA 0.507 no no no no no no Ubiquitin mediated proteolysis iso-LCA+blood 0.547141303 0 0 kegg serum_bileacids NA 0.507 no no no no no no UDCA+stool iso-LCA+blood -0.601729673 -0.663341671 -0.584041363 stool_bileacids serum_bileacids 0.266 0.507 no no no no no no 12-ketoDCA+stool iso-LCA+stool 0 0.721542262 0.526679842 stool_bileacids stool_bileacids 0.505 0.72 no no no no no no 4-hydroxybenzoic acid+stool iso-LCA+stool 0 -0.727272727 0 stool_cometabolism stool_bileacids 0.0536 0.72 no dn no no no no Allograft rejection iso-LCA+stool 0 -0.709090909 0 kegg stool_bileacids NA 0.72 no no no no no no Alzheimer disease iso-LCA+stool 0.486319115 0 0 kegg stool_bileacids NA 0.72 no no no no no no Amphetamine addiction iso-LCA+stool 0.601961877 0 0 kegg stool_bileacids NA 0.72 no no no no no no Amyotrophic lateral sclerosis iso-LCA+stool 0.6071245 0 -0.489553924 kegg stool_bileacids NA 0.72 no no no no no no Antigen processing and presentation iso-LCA+stool 0 -0.727272727 0 kegg stool_bileacids NA 0.72 no no no no no no Autoimmune thyroid disease iso-LCA+stool 0 -0.709090909 0 kegg stool_bileacids NA 0.72 no no no no no no Autophagy - animal iso-LCA+stool 0 0 0.552795031 kegg stool_bileacids NA 0.72 no no no no no no Bacterial invasion of epithelial cells iso-LCA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.72 no no no no no no Bacteroides iso-LCA+stool -0.541042922 0 0 LPS-producing Genus stool_bileacids 0.000267 0.72 dn dn up no no no Biosynthesis of amino acids iso-LCA+stool -0.554465742 0 0 kegg stool_bileacids NA 0.72 no no no no no no CA+stool iso-LCA+stool -0.751677953 -0.657342657 -0.644268775 stool_bileacids stool_bileacids 0.827 0.72 no no no no no no Carbon metabolism iso-LCA+stool 0 -0.836363636 0 kegg stool_bileacids NA 0.72 no no no no no no Cardiac muscle contraction iso-LCA+stool 0.481156492 0 -0.469226426 kegg stool_bileacids NA 0.72 no no up no no no CDCA+stool iso-LCA+stool -0.886938683 -0.594405594 -0.683794466 stool_bileacids stool_bileacids 0.663 0.72 no no no no no no Cell adhesion molecules iso-LCA+stool 0 -0.736363636 0 kegg stool_bileacids NA 0.72 no no no no no no Cellular senescence iso-LCA+stool -0.600929352 -0.618181818 0 kegg stool_bileacids NA 0.72 no no no no no no Central carbon metabolism in cancer iso-LCA+stool 0 0 0.557312253 kegg stool_bileacids NA 0.72 no no no no no no Chemical carcinogenesis - receptor activation iso-LCA+stool 0 0.790909091 0 kegg stool_bileacids NA 0.72 no no no no no no Choline metabolism in cancer iso-LCA+stool 0 0.609090909 0 kegg stool_bileacids NA 0.72 no no no no no no Circadian entrainment iso-LCA+stool 0.478058918 0 0 kegg stool_bileacids NA 0.72 no up up no no no Clostridium iso-LCA+stool 0 -0.60090525 0 Genus stool_bileacids 0.925 0.72 no no no no no no Cocaine addiction iso-LCA+stool 0 0.736363636 0 kegg stool_bileacids NA 0.72 no no no no no no Coprococcus iso-LCA+stool 0 0 0.495059289 butyrate-producing Genus stool_bileacids 0.612 0.72 no no no no no no Cortisol synthesis and secretion iso-LCA+stool 0 0.754545455 0 kegg stool_bileacids NA 0.72 no no up no no no Cushing syndrome iso-LCA+stool 0.486319115 0.790909091 0 kegg stool_bileacids NA 0.72 no no up no no no DCA+stool iso-LCA+stool 0.596799254 0.811188811 0.533596838 stool_bileacids stool_bileacids 0.195 0.72 no no no no no no Diabetic cardiomyopathy iso-LCA+stool 0.478058918 0 -0.505364201 kegg stool_bileacids NA 0.72 no no no no no no Dorea iso-LCA+stool -0.534847774 0 0 Genus stool_bileacids 0.00362 0.72 up no dn no no no Eggerthella iso-LCA+stool 0 -0.591312396 0 Genus stool_bileacids 0.912 0.72 no no no no no no Endocrine resistance iso-LCA+stool 0 0.736363636 0 kegg stool_bileacids NA 0.72 no no no no no no Endocytosis iso-LCA+stool -0.559628366 -0.763636364 0 kegg stool_bileacids NA 0.72 no no no no no no Epithelial cell signaling in Helicobacter pylori infection iso-LCA+stool -0.610222074 0 0 kegg stool_bileacids NA 0.72 no no no no no no Epstein-Barr virus infection iso-LCA+stool 0 -0.609090909 0 kegg stool_bileacids NA 0.72 no no no no no no Fluid shear stress and atherosclerosis iso-LCA+stool 0 -0.763636364 0 kegg stool_bileacids NA 0.72 no no no no no no FoxO signaling pathway iso-LCA+stool -0.489416689 0 0.691699605 kegg stool_bileacids NA 0.72 no no no no no no GABAergic synapse iso-LCA+stool -0.597831778 0 0 kegg stool_bileacids NA 0.72 no up up no no no Gastric acid secretion iso-LCA+stool 0.491481738 0 0 kegg stool_bileacids NA 0.72 no no no no no no Gastric cancer iso-LCA+stool 0 0 0.461321287 kegg stool_bileacids NA 0.72 no no no no no no GCA+stool iso-LCA+stool 0 -0.79020979 0 stool_bileacids stool_bileacids 0.0809 0.72 no no no no no no GLCA+stool iso-LCA+stool -0.655204588 0 0 stool_bileacids stool_bileacids 0.617 0.72 no no no no no no GnRH signaling pathway iso-LCA+stool 0 0.7 0 kegg stool_bileacids NA 0.72 no no no no no no Graft-versus-host disease iso-LCA+stool 0 -0.709090909 0 kegg stool_bileacids NA 0.72 no no no no no no "Growth hormone synthesis, secretion and action" iso-LCA+stool 0 0.672727273 0 kegg stool_bileacids NA 0.72 no no no no no no HCA+stool iso-LCA+stool -0.671141029 0 -0.479249012 stool_bileacids stool_bileacids 0.155 0.72 no no no no no no HDCA+stool iso-LCA+stool 0.528652626 0.594405594 0.555335968 stool_bileacids stool_bileacids 0.176 0.72 no no no no no no Hepatocellular carcinoma iso-LCA+stool 0.472896294 0 0 kegg stool_bileacids NA 0.72 no no no no no no Herpes simplex virus 1 infection iso-LCA+stool 0 -0.645454545 0 kegg stool_bileacids NA 0.72 no no no no no no Hippo signaling pathway iso-LCA+stool 0.538977873 0 0 kegg stool_bileacids NA 0.72 no no no no no no Human cytomegalovirus infection iso-LCA+stool 0 -0.636363636 0 kegg stool_bileacids NA 0.72 no no dn no no no Human immunodeficiency virus 1 infection iso-LCA+stool 0 -0.609090909 0 kegg stool_bileacids NA 0.72 no no no no no no Human papillomavirus infection iso-LCA+stool -0.566856038 0 0 kegg stool_bileacids NA 0.72 no no no no no no Human T-cell leukemia virus 1 infection iso-LCA+stool 0 -0.681818182 0 kegg stool_bileacids NA 0.72 no no no no no no Huntington disease iso-LCA+stool 0.550335644 0 -0.453416149 kegg stool_bileacids NA 0.72 no no no no no no IL-17 signaling pathway iso-LCA+stool -0.585441482 0 0 kegg stool_bileacids NA 0.72 no no no no no no Insulin secretion iso-LCA+stool 0 0.718181818 0 yes kegg stool_bileacids NA 0.72 no up up no no no iso-DCA+stool iso-LCA+stool 0.561693415 0 0 stool_bileacids stool_bileacids 0.155 0.72 no no no no no no Leishmaniasis iso-LCA+stool 0 -0.709090909 0 kegg stool_bileacids NA 0.72 no no no no no no Leukocyte transendothelial migration iso-LCA+stool 0 -0.745454545 0 kegg stool_bileacids NA 0.72 no no no no no no Lipid and atherosclerosis iso-LCA+stool -0.557563316 0 0 kegg stool_bileacids NA 0.72 no no no no no no MAPK signaling pathway iso-LCA+stool 0 0 0.50310559 kegg stool_bileacids NA 0.72 no no no no no no Melanogenesis iso-LCA+stool 0.554465742 0 0 kegg stool_bileacids NA 0.72 no no no no no no Morphine addiction iso-LCA+stool 0 0.736363636 0 kegg stool_bileacids NA 0.72 no up up no no no Natural killer cell mediated cytotoxicity iso-LCA+stool -0.475993868 -0.727272727 0 kegg stool_bileacids NA 0.72 no no no no no no Neuroactive ligand-receptor interaction iso-LCA+stool 0 -0.681818182 0 kegg stool_bileacids NA 0.72 up up up no no no Neutrophil extracellular trap formation iso-LCA+stool -0.470831245 0 0 kegg stool_bileacids NA 0.72 no no no no no no NF-kappa B signaling pathway iso-LCA+stool -0.508002133 0 0 kegg stool_bileacids NA 0.72 no no no no no no NOD-like receptor signaling pathway iso-LCA+stool -0.540010397 0 0 kegg stool_bileacids NA 0.72 no no no no no no Non-alcoholic fatty liver disease iso-LCA+stool 0 0 -0.466967815 kegg stool_bileacids NA 0.72 no no no no no no Odoribacter iso-LCA+stool 0 -0.881118881 0 butyrate-producing Genus stool_bileacids 0.798 0.72 no no no no no no Oscillospira iso-LCA+stool 0.51626233 0 0 LPS-producing Genus stool_bileacids 0.62 0.72 no no no no no no Osteoclast differentiation iso-LCA+stool -0.490449214 0 0 kegg stool_bileacids NA 0.72 no no no no no no Oxidative phosphorylation iso-LCA+stool 0.515229805 0 -0.501976285 kegg stool_bileacids NA 0.72 no no no no no no p53 signaling pathway iso-LCA+stool 0 0.772727273 0 kegg stool_bileacids NA 0.72 no no no no no no Pancreatic cancer iso-LCA+stool 0 0 0.669113495 kegg stool_bileacids NA 0.72 no no no no no no Pathogenic Escherichia coli infection iso-LCA+stool 0 -0.718181818 0 kegg stool_bileacids NA 0.72 no no no no no no Pathways in cancer iso-LCA+stool 0 0.863636364 0.529079616 kegg stool_bileacids NA 0.72 no no no no no no Peroxisome iso-LCA+stool -0.604026926 0 0 kegg stool_bileacids NA 0.72 no no no no no no Pertussis iso-LCA+stool -0.574083711 0 0 kegg stool_bileacids NA 0.72 no no dn no no no Phagosome iso-LCA+stool 0 -0.736363636 0 kegg stool_bileacids NA 0.72 no no no no no no Platelet activation iso-LCA+stool 0.483221541 0 0 kegg stool_bileacids NA 0.72 no no no no no no Platinum drug resistance iso-LCA+stool 0 0 0.629587804 kegg stool_bileacids NA 0.72 no no no no no no Prion disease iso-LCA+stool 0.505937083 0 0 kegg stool_bileacids NA 0.72 no no no no no no Proteasome iso-LCA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.72 no no no no no no Renal cell carcinoma iso-LCA+stool 0 0 0.628458498 kegg stool_bileacids NA 0.72 no no no no no no Renin secretion iso-LCA+stool 0.472896294 0 0 kegg stool_bileacids NA 0.72 no no no no no no RIG-I-like receptor signaling pathway iso-LCA+stool -0.579246334 0 0 kegg stool_bileacids NA 0.72 no no no no no no Salmonella infection iso-LCA+stool 0 -0.790909091 0 kegg stool_bileacids NA 0.72 no no no no no no Serotonergic synapse iso-LCA+stool 0 0.609090909 0 kegg stool_bileacids NA 0.72 no no no no no no Signaling pathways regulating pluripotency of stem cells iso-LCA+stool 0 0.681818182 0.476002259 kegg stool_bileacids NA 0.72 no no no no no no T cell receptor signaling pathway iso-LCA+stool 0 0 0.471485037 kegg stool_bileacids NA 0.72 no no no no no no Thermogenesis iso-LCA+stool 0.66701093 0 -0.508752117 kegg stool_bileacids NA 0.72 no no no no no no Thyroid hormone signaling pathway iso-LCA+stool 0.529685151 0 0 kegg stool_bileacids NA 0.72 no no no no no no Tight junction iso-LCA+stool 0 -0.7 0 kegg stool_bileacids NA 0.72 no no no no no no Transcriptional misregulation in cancer iso-LCA+stool -0.619514796 0 0 kegg stool_bileacids NA 0.72 no no no no no no Type I diabetes mellitus iso-LCA+stool 0 -0.709090909 0 kegg stool_bileacids NA 0.72 no no no no no no Vibrio cholerae infection iso-LCA+stool 0 0 -0.526821005 kegg stool_bileacids NA 0.72 no no no no no no Viral carcinogenesis iso-LCA+stool -0.523490003 0 0 kegg stool_bileacids NA 0.72 no no no no no no Viral myocarditis iso-LCA+stool 0 -0.727272727 0 kegg stool_bileacids NA 0.72 no no no no no no Wnt signaling pathway iso-LCA+stool 0.48735164 0 0 kegg stool_bileacids NA 0.72 no no no no no no 12-ketoDCA+blood isobutyric acid C4+blood -0.519474976 0 0 serum_bileacids serum_scfa 0.517 0.0151 no no no up up no 13-HODE+blood isobutyric acid C4+blood 0 0.625 0 serum_ARA serum_scfa 0.32 0.0151 no no no up up no 16:0/18:0-PC+blood isobutyric acid C4+blood 0 0 -0.42974359 serum_phospholipids serum_scfa 0.521 0.0151 no no no up up no 18:0-LPA+blood isobutyric acid C4+blood 0 0 0.428376068 serum_phospholipids serum_scfa 0.0725 0.0151 no dn no up up no 18:1/18:2-PI+blood isobutyric acid C4+blood -0.455639098 0 0 serum_phospholipids serum_scfa 0.0164 0.0151 dn no up up up no 18:2-LPC+blood isobutyric acid C4+blood 0 0.549019608 0 serum_phospholipids serum_scfa 0.00743 0.0151 dn no up up up no 18:3/18:2-PC+blood isobutyric acid C4+blood 0 0 -0.457094017 serum_phospholipids serum_scfa 0.0394 0.0151 no no up up up no 2-methyl-butyric acid m-C4+blood isobutyric acid C4+blood 0.639097744 0.639705882 0.807179487 serum_scfa serum_scfa 0.262 0.0151 no no no up up no 20:1+blood isobutyric acid C4+blood 0 0.612745098 0 yes serum_fattyacid serum_scfa 2.56E-05 0.0151 dn dn dn up up no 9-HODE+blood isobutyric acid C4+blood 0 0.75245098 0 serum_ARA serum_scfa 0.297 0.0151 no no no up up no acetic acid C2+blood isobutyric acid C4+blood 0.514285714 0 0 serum_scfa serum_scfa 0.000193 0.0151 up dn no up up no butyric acid C4+blood isobutyric acid C4+blood 0.581954887 0.661764706 0.60957265 serum_scfa serum_scfa 0.407 0.0151 no no no up up no CA+blood isobutyric acid C4+blood 0 0 -0.466212006 serum_bileacids serum_scfa 0.606 0.0151 no no no up up no DCA+blood isobutyric acid C4+blood -0.568421053 0 0 serum_bileacids serum_scfa 0.122 0.0151 no no no up up no decanoic acid C10+blood isobutyric acid C4+blood 0.494736842 0 0 serum_mcfa serum_scfa 6.64E-11 0.0151 dn dn no up up no heptanoic acid C7+blood isobutyric acid C4+blood 0.532330827 0 0.426324786 serum_mcfa serum_scfa 8.27E-11 0.0151 dn dn no up up no iso-LCA+blood isobutyric acid C4+blood 0 0.527690906 0 serum_bileacids serum_scfa 0.507 0.0151 no no no up up no 4-hydroxybenzoic acid+stool Isobutyric acid+stool 0 0 -0.523715415 stool_cometabolism stool_scfa 0.0536 0.408 no dn no no no no CA+stool Isobutyric acid+stool 0 -0.713286713 -0.558300395 stool_bileacids stool_scfa 0.827 0.408 no no no no no no CDCA+stool Isobutyric acid+stool -0.479876161 -0.909090909 -0.731225296 stool_bileacids stool_scfa 0.663 0.408 no no no no no no GCA+stool Isobutyric acid+stool -0.506707946 -0.678321678 0 stool_bileacids stool_scfa 0.0809 0.408 no no no no no no GCDCA+stool Isobutyric acid+stool -0.488132095 -0.93006993 0 yes stool_bileacids stool_scfa 0.0471 0.408 no dn no no no no GDCA+stool Isobutyric acid+stool 0 -0.76357385 0 stool_bileacids stool_scfa 0.656 0.408 no no no no no no Indole-3-Acetic acid+stool Isobutyric acid+stool 0.552115583 0.762237762 0.5256917 stool_cometabolism stool_scfa 0.304 0.408 no no no no no no iso-LCA+stool Isobutyric acid+stool 0.518327379 0 0 stool_bileacids stool_scfa 0.72 0.408 no no no no no no ¦Ø-MCA+stool Isobutyric acid+stool 0 -0.584849771 0 stool_bileacids stool_scfa 0.919 0.408 no no no no no no 12-ketoDCA+blood isocapric acid iso-C6+blood -0.561420161 0 0 serum_bileacids serum_scfa 0.517 0.0458 no no no no no dn 13-HODE+blood isocapric acid iso-C6+blood 0 0 -0.456410256 serum_ARA serum_scfa 0.32 0.0458 no no no no no dn 14:0/18:0-PC+blood isocapric acid iso-C6+blood -0.479699248 0 0 serum_phospholipids serum_scfa 0.00289 0.0458 up up no no no dn 14:1/18:2-PG+blood isocapric acid iso-C6+blood 0 -0.553921569 0 serum_phospholipids serum_scfa 0.00259 0.0458 no up up no no dn 15-HETE+blood isocapric acid iso-C6+blood 0 0.633797496 0 serum_ARA serum_scfa 0.819 0.0458 no no no no no dn 16:0-LPE+blood isocapric acid iso-C6+blood 0 0.610294118 0 serum_phospholipids serum_scfa 0.0711 0.0458 up up no no no dn 16:0/16:1-PC+blood isocapric acid iso-C6+blood -0.44962406 0 0 serum_phospholipids serum_scfa 0.00283 0.0458 up up no no no dn 16:0/20:3-PC+blood isocapric acid iso-C6+blood 0.469172932 0 0 serum_phospholipids serum_scfa 5.43E-06 0.0458 no up up no no dn 18:0/22:6-PI+blood isocapric acid iso-C6+blood 0 0 -0.518632479 serum_phospholipids serum_scfa 0.425 0.0458 no no no no no dn 18:3n3+blood isocapric acid iso-C6+blood 0 0.487745098 0 serum_fattyacid serum_scfa 0.291 0.0458 no no no no no dn 20:1-LPE+blood isocapric acid iso-C6+blood 0.521804511 0 0 serum_phospholipids serum_scfa 0.465 0.0458 no no no no no dn 20:5/18:0-PC+blood isocapric acid iso-C6+blood 0.45112782 0 0 serum_phospholipids serum_scfa 3.97E-06 0.0458 no up up no no dn 22:6n3+blood isocapric acid iso-C6+blood 0 0 -0.422905983 serum_fattyacid serum_scfa 0.792 0.0458 no no no no no dn CA+blood isocapric acid iso-C6+blood -0.47461455 0 0 serum_bileacids serum_scfa 0.606 0.0458 no no no no no dn d18:1-18:1-SM+blood isocapric acid iso-C6+blood 0 0 0.444786325 serum_phospholipids serum_scfa 0.916 0.0458 no no no no no dn d18:1-20:1-SM+blood isocapric acid iso-C6+blood 0 0 0.566495726 serum_phospholipids serum_scfa 0.0992 0.0458 no no no no no dn GCDCA+blood isocapric acid iso-C6+blood 0 -0.544117647 0 serum_bileacids serum_scfa 0.31 0.0458 no no no no no dn GDCA+blood isocapric acid iso-C6+blood 0 0 -0.444786325 serum_bileacids serum_scfa 0.632 0.0458 no no no no no dn HCA+blood isocapric acid iso-C6+blood -0.48842437 0 0 serum_bileacids serum_scfa 0.544 0.0458 no no no no no dn 16:0/16:0-PI+blood isovaleric acid iso-C5+blood 0 -0.490196078 0 serum_phospholipids serum_scfa 0.358 0.117 no no no no no no 16:0/20:5-PG+blood isovaleric acid iso-C5+blood 0 0.580882353 0 serum_phospholipids serum_scfa 0.00656 0.117 no up no no no no 18:0/18:1-PG+blood isovaleric acid iso-C5+blood -0.520300752 0 0 serum_phospholipids serum_scfa 0.000842 0.117 no up no no no no 18:0/18:1-PI+blood isovaleric acid iso-C5+blood -0.544360902 0 0 serum_phospholipids serum_scfa 0.599 0.117 no no no no no no 18:0/20:2-PC+blood isovaleric acid iso-C5+blood 0 -0.632352941 0 serum_phospholipids serum_scfa 0.733 0.117 no no no no no no 18:0/20:3-PC+blood isovaleric acid iso-C5+blood 0 -0.593137255 0 serum_phospholipids serum_scfa 0.0682 0.117 no up no no no no 18:1/18:1-PC+blood isovaleric acid iso-C5+blood 0 -0.507352941 0 serum_phospholipids serum_scfa 1.34E-05 0.117 no up up no no no 18:1/20:3-PC+blood isovaleric acid iso-C5+blood 0 -0.56127451 0 serum_phospholipids serum_scfa 0.00872 0.117 no up up no no no 18:2/18:2-PS+blood isovaleric acid iso-C5+blood 0 0 0.432478632 serum_phospholipids serum_scfa 0.00674 0.117 up up no no no no 20:1+blood isovaleric acid iso-C5+blood 0 0 0.435213675 yes serum_fattyacid serum_scfa 2.56E-05 0.117 dn dn dn no no no 20:2/18:0-PC+blood isovaleric acid iso-C5+blood 0 -0.571078431 0 serum_phospholipids serum_scfa 0.0427 0.117 no up no no no no 20:4-LPC+blood isovaleric acid iso-C5+blood 0 0.531862745 0 serum_phospholipids serum_scfa 0.949 0.117 no no no no no no 20:5-LPC+blood isovaleric acid iso-C5+blood 0 0.514705882 0 serum_phospholipids serum_scfa 0.558 0.117 no no no no no no 22:6-LPC+blood isovaleric acid iso-C5+blood 0 0.509803922 0 serum_phospholipids serum_scfa 0.127 0.117 no no up no no no butyric acid C4+blood isovaleric acid iso-C5+blood 0.479699248 0 0 serum_scfa serum_scfa 0.407 0.117 no no no no no no Cysteine+blood isovaleric acid iso-C5+blood 0 0 0.405128205 yes serum_aminoacids serum_scfa 1.81E-07 0.117 dn up up no no no d18:0-16:0-SM+blood isovaleric acid iso-C5+blood 0 0 0.459145299 serum_phospholipids serum_scfa 0.202 0.117 no no no no no no d18:0-24:1-SM+blood isovaleric acid iso-C5+blood 0 -0.490196078 0 serum_phospholipids serum_scfa 0.0609 0.117 no dn dn no no no d18:1-16:0-SM+blood isovaleric acid iso-C5+blood 0 0 0.42017094 serum_phospholipids serum_scfa 0.14 0.117 no no no no no no decanoic acid C10+blood isovaleric acid iso-C5+blood 0 -0.490196078 0 serum_mcfa serum_scfa 6.64E-11 0.117 dn dn no no no no EPA+blood isovaleric acid iso-C5+blood 0 0.590686275 0 serum_ARA serum_scfa 0.212 0.117 no no no no no no GUDCA+blood isovaleric acid iso-C5+blood 0 0 -0.406495726 serum_bileacids serum_scfa 0.0766 0.117 no no dn no no no isobutyric acid C4+blood isovaleric acid iso-C5+blood 0 0 0.474871795 serum_scfa serum_scfa 0.0151 0.117 up up no no no no 4-hydroxybenzoic acid+stool Isovaleric acid+stool -0.525283798 0 -0.564229249 stool_cometabolism stool_scfa 0.0536 0.343 no dn no no no no Acetic acid+stool Isovaleric acid+stool 0 0 -0.424901186 yes stool_scfa stool_scfa 0.0656 0.343 dn no no no no no CA+stool Isovaleric acid+stool 0 0 -0.567193676 stool_bileacids stool_scfa 0.827 0.343 no no no no no no CDCA+stool Isovaleric acid+stool -0.570691434 -0.804195804 -0.744071146 stool_bileacids stool_scfa 0.663 0.343 no no no no no no GCA+stool Isovaleric acid+stool -0.471620227 -0.58041958 0 stool_bileacids stool_scfa 0.0809 0.343 no no no no no no GCDCA+stool Isovaleric acid+stool -0.488132095 -0.972027972 0 yes stool_bileacids stool_scfa 0.0471 0.343 no dn no no no no GDCA+stool Isovaleric acid+stool 0 -0.626971189 0 stool_bileacids stool_scfa 0.656 0.343 no no no no no no Indole-3-Acetic acid+stool Isovaleric acid+stool 0.533539732 0.762237762 0.52173913 stool_cometabolism stool_scfa 0.304 0.343 no no no no no no iso-LCA+stool Isovaleric acid+stool 0.557563316 0 0 stool_bileacids stool_scfa 0.72 0.343 no no no no no no Isobutyric acid+stool Isovaleric acid+stool 0.900928793 0.93006993 0.984189723 stool_scfa stool_scfa 0.408 0.343 no no no no no no ABC transporters JAK-STAT signaling pathway 0.486086957 0.713438735 0.594337194 kegg kegg NA NA no up up no no no Adherens junction JAK-STAT signaling pathway 0 -0.78458498 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes JAK-STAT signaling pathway -0.406956522 -0.556324111 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" JAK-STAT signaling pathway 0.429565217 0.720355731 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism JAK-STAT signaling pathway 0 0.701581028 0 kegg kegg NA NA no no no no no no Antigen processing and presentation JAK-STAT signaling pathway 0 -0.415019763 0 kegg kegg NA NA no no no no no no Apelin signaling pathway JAK-STAT signaling pathway 0 -0.794466403 0 kegg kegg NA NA no no no no no no Apoptosis JAK-STAT signaling pathway 0 0.539525692 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species JAK-STAT signaling pathway 0 0.677865613 0.51969112 kegg kegg NA NA no no no no no no Arachidonic acid metabolism JAK-STAT signaling pathway -0.413043478 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism JAK-STAT signaling pathway 0 0.579051383 0 kegg kegg NA NA no up no no no no Arginine biosynthesis JAK-STAT signaling pathway 0.430434783 0.638339921 0 kegg kegg NA NA no no no no no no Autophagy - animal JAK-STAT signaling pathway 0.42173913 0.852766798 0 kegg kegg NA NA no no no no no no Autophagy - other JAK-STAT signaling pathway 0 0.622529644 0 kegg kegg NA NA no no no no no no Butanoate metabolism JAK-STAT signaling pathway 0 -0.570158103 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway JAK-STAT signaling pathway 0 0.636363636 0 kegg kegg NA NA no no no no no no Calcium signaling pathway JAK-STAT signaling pathway 0 -0.428853755 0 kegg kegg NA NA no up up no no no Cardiac muscle contraction JAK-STAT signaling pathway 0 -0.699604743 0 kegg kegg NA NA no no up no no no Citrate cycle (TCA cycle) JAK-STAT signaling pathway 0 -0.614624506 0 kegg kegg NA NA no no no no no no Clostridium JAK-STAT signaling pathway 0 -0.476800962 0 Genus kegg 0.925 NA no no no no no no Cysteine and methionine metabolism JAK-STAT signaling pathway 0 -0.65513834 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway JAK-STAT signaling pathway 0 0 -0.402574003 kegg kegg NA NA no no no no no no DNA replication JAK-STAT signaling pathway 0 -0.416996047 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 JAK-STAT signaling pathway 0 -0.654150198 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes JAK-STAT signaling pathway 0 -0.787549407 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance JAK-STAT signaling pathway 0 -0.67687747 0 kegg kegg NA NA no no no no no no ErbB signaling pathway JAK-STAT signaling pathway 0 0.68083004 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis JAK-STAT signaling pathway 0.427826087 0.709486166 0.431402831 kegg kegg NA NA no no no no no no Fatty acid degradation JAK-STAT signaling pathway 0.431304348 0.630434783 0 kegg kegg NA NA no no no no no no Fatty acid elongation JAK-STAT signaling pathway 0 -0.497035573 0 kegg kegg NA NA no no no no no no Fatty acid metabolism JAK-STAT signaling pathway 0 0.48715415 0 kegg kegg NA NA no no no no no no Focal adhesion JAK-STAT signaling pathway 0 -0.767786561 0 kegg kegg NA NA no up up no no no FoxO signaling pathway JAK-STAT signaling pathway 0.705217391 0.896245059 0.708108108 kegg kegg NA NA no no no no no no Fructose and mannose metabolism JAK-STAT signaling pathway 0 0.698616601 0 kegg kegg NA NA no no no no no no Galactose metabolism JAK-STAT signaling pathway 0.420869565 0.720355731 0 kegg kegg NA NA no no no no no no Glutathione metabolism JAK-STAT signaling pathway -0.506956522 -0.650197628 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism JAK-STAT signaling pathway 0.61826087 0.815217391 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism JAK-STAT signaling pathway 0 0.675889328 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis JAK-STAT signaling pathway 0 -0.734189723 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate JAK-STAT signaling pathway 0 0.853754941 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series JAK-STAT signaling pathway 0 0.464426877 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis JAK-STAT signaling pathway 0.42 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism JAK-STAT signaling pathway 0 0.611660079 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway JAK-STAT signaling pathway 0 -0.73715415 0 kegg kegg NA NA no no no no no no Hippo signaling pathway JAK-STAT signaling pathway 0 -0.722332016 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species JAK-STAT signaling pathway 0 0.645256917 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism JAK-STAT signaling pathway 0.666956522 0.718379447 0.471814672 kegg kegg NA NA no no no no no no Lachnospira JAK-STAT signaling pathway 0.456521739 -0.548060308 0 butyrate-producing Genus kegg 0.279 NA no no no no no no MAPK signaling pathway JAK-STAT signaling pathway 0.606956522 0.615612648 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 JAK-STAT signaling pathway 0 -0.674901186 0 kegg kegg NA NA no no no no no no Mitophagy - animal JAK-STAT signaling pathway -0.455652174 -0.472332016 0 kegg kegg NA NA no no no no no no mTOR signaling pathway JAK-STAT signaling pathway 0 -0.678853755 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis JAK-STAT signaling pathway 0 -0.5 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway JAK-STAT signaling pathway 0.516521739 0.84486166 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism JAK-STAT signaling pathway 0.408695652 0.656126482 0 kegg kegg NA NA no no no no no no Nitrogen metabolism JAK-STAT signaling pathway 0 0.538537549 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway JAK-STAT signaling pathway 0.454782609 0.707509881 0 kegg kegg NA NA no no no no no no Non-homologous end-joining JAK-STAT signaling pathway 0 -0.518774704 0 kegg kegg NA NA no no no no no no Notch signaling pathway JAK-STAT signaling pathway 0 0.583003953 0 kegg kegg NA NA no no no no no no Oocyte meiosis JAK-STAT signaling pathway 0 -0.690711462 0 kegg kegg NA NA no no no no no no Oscillospira JAK-STAT signaling pathway 0 0.518774704 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation JAK-STAT signaling pathway 0.446956522 0.561264822 0 kegg kegg NA NA no no no no no no Other glycan degradation JAK-STAT signaling pathway 0 0.679841897 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation JAK-STAT signaling pathway 0 -0.756916996 0 kegg kegg NA NA no no no no no no p53 signaling pathway JAK-STAT signaling pathway 0 0.567193676 0.542342342 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis JAK-STAT signaling pathway 0.533043478 0.583003953 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions JAK-STAT signaling pathway 0 -0.583003953 0 kegg kegg NA NA no no no no no no Peroxisome JAK-STAT signaling pathway 0 0.538537549 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism JAK-STAT signaling pathway 0 -0.486166008 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway JAK-STAT signaling pathway 0 0.7243083 0 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway JAK-STAT signaling pathway 0.422608696 0 0 yes kegg kegg NA NA no up up no no no Platelet activation JAK-STAT signaling pathway 0 -0.707509881 0 kegg kegg NA NA no no no no no no Platinum drug resistance JAK-STAT signaling pathway 0 0.60770751 0.513770914 kegg kegg NA NA no no no no no no PPAR signaling pathway JAK-STAT signaling pathway 0 0.47826087 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis JAK-STAT signaling pathway 0 -0.52173913 0 kegg kegg NA NA no no no no no no Propanoate metabolism JAK-STAT signaling pathway 0 -0.660079051 0 kegg kegg NA NA no no no no no no Proteasome JAK-STAT signaling pathway 0 -0.705533597 0 kegg kegg NA NA no no no no no no Protein export JAK-STAT signaling pathway 0 -0.781620553 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum JAK-STAT signaling pathway -0.430434783 -0.501976285 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism JAK-STAT signaling pathway 0 0 0.503989704 kegg kegg NA NA no no no no no no Pyruvate metabolism JAK-STAT signaling pathway 0 -0.692687747 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway JAK-STAT signaling pathway 0 -0.544466403 0 kegg kegg NA NA no no no no no no Ras signaling pathway JAK-STAT signaling pathway 0 -0.615612648 0 yes kegg kegg NA NA no up up no no no Ribosome JAK-STAT signaling pathway 0 -0.804347826 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway JAK-STAT signaling pathway 0 0.783596838 0 kegg kegg NA NA no no no no no no RNA degradation JAK-STAT signaling pathway 0 -0.514822134 0 kegg kegg NA NA no no no no no no RNA transport JAK-STAT signaling pathway 0 -0.616600791 0 kegg kegg NA NA no no no no no no Ruminococcus JAK-STAT signaling pathway 0 -0.443785412 0 Genus kegg 0.0679 NA no no dn no no no Selenocompound metabolism JAK-STAT signaling pathway 0 0.423913043 0.502445302 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway 0 0.455533597 0.436036036 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport JAK-STAT signaling pathway 0 0.734189723 0 kegg kegg NA NA no no no no no no Spliceosome JAK-STAT signaling pathway 0 0.527667984 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism JAK-STAT signaling pathway 0.523478261 0.68083004 0 kegg kegg NA NA no no no no no no Sulfur metabolism JAK-STAT signaling pathway 0 -0.444664032 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism JAK-STAT signaling pathway 0.503478261 0.793478261 0.43963964 kegg kegg NA NA no no no no no no TGF-beta signaling pathway JAK-STAT signaling pathway 0 -0.785573123 0 kegg kegg NA NA no no no no no no Thiamine metabolism JAK-STAT signaling pathway 0 -0.615612648 0 kegg kegg NA NA no no no no no no Tight junction JAK-STAT signaling pathway 0 -0.798418972 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway JAK-STAT signaling pathway 0 0.613636364 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism JAK-STAT signaling pathway 0 -0.486166008 0 kegg kegg NA NA no up no no no no Tyrosine metabolism JAK-STAT signaling pathway 0 -0.48715415 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis JAK-STAT signaling pathway -0.492173913 -0.470355731 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" JAK-STAT signaling pathway 0 -0.450592885 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction JAK-STAT signaling pathway -0.531304348 -0.7756917 -0.544144144 kegg kegg NA NA no no no no no no VEGF signaling pathway JAK-STAT signaling pathway 0 0.472332016 0 kegg kegg NA NA no no no no no no Wnt signaling pathway JAK-STAT signaling pathway 0 -0.456521739 0 kegg kegg NA NA no no no no no no ABC transporters Kaposi sarcoma-associated herpesvirus infection -0.442608696 0 0 kegg kegg NA NA no up up no no dn Adipocytokine signaling pathway Kaposi sarcoma-associated herpesvirus infection 0.759130435 0.483201581 0.634234234 kegg kegg NA NA no no no no no dn Adrenergic signaling in cardiomyocytes Kaposi sarcoma-associated herpesvirus infection 0.54173913 0 0 kegg kegg NA NA no no up no no dn Alcoholism Kaposi sarcoma-associated herpesvirus infection 0 0 0.412612613 kegg kegg NA NA no no no no no dn Aldosterone synthesis and secretion Kaposi sarcoma-associated herpesvirus infection 0.46173913 0 0 kegg kegg NA NA no up up no no dn Aldosterone-regulated sodium reabsorption Kaposi sarcoma-associated herpesvirus infection 0 0 -0.607207207 kegg kegg NA NA no no no no no dn alpha-Linolenic acid metabolism Kaposi sarcoma-associated herpesvirus infection 0 0 -0.531274131 kegg kegg NA NA no no no no no dn Alzheimer disease Kaposi sarcoma-associated herpesvirus infection 0 0.454545455 0 kegg kegg NA NA no no no no no dn Amino sugar and nucleotide sugar metabolism Kaposi sarcoma-associated herpesvirus infection -0.524347826 -0.519762846 0 kegg kegg NA NA no no no no no dn Aminoacyl-tRNA biosynthesis Kaposi sarcoma-associated herpesvirus infection -0.484347826 -0.446640316 0 kegg kegg NA NA no no no no no dn AMPK signaling pathway Kaposi sarcoma-associated herpesvirus infection 0.44 0 0.571943372 kegg kegg NA NA no no no no no dn Antifolate resistance Kaposi sarcoma-associated herpesvirus infection 0 -0.580039526 0 kegg kegg NA NA no no no no no dn Antigen processing and presentation Kaposi sarcoma-associated herpesvirus infection 0 0.431818182 0 kegg kegg NA NA no no no no no dn Arachidonic acid metabolism Kaposi sarcoma-associated herpesvirus infection 0 0 0.427541828 kegg kegg NA NA no no no no no dn Ascorbate and aldarate metabolism Kaposi sarcoma-associated herpesvirus infection -0.584347826 0 -0.545688546 kegg kegg NA NA no no no no no dn Autophagy - animal Kaposi sarcoma-associated herpesvirus infection 0 0 -0.402831403 kegg kegg NA NA no no no no no dn Axon guidance Kaposi sarcoma-associated herpesvirus infection 0.414782609 0 0 kegg kegg NA NA no up up no no dn Base excision repair Kaposi sarcoma-associated herpesvirus infection 0 -0.503952569 0 kegg kegg NA NA no no no no no dn beta-Alanine metabolism Kaposi sarcoma-associated herpesvirus infection -0.591304348 -0.486166008 0 kegg kegg NA NA no no no no no dn Bile secretion Kaposi sarcoma-associated herpesvirus infection 0.492173913 0 0.501930502 kegg kegg NA NA no no no no no dn Biosynthesis of cofactors Kaposi sarcoma-associated herpesvirus infection 0 0 0.509395109 kegg kegg NA NA no no no no no dn Biosynthesis of unsaturated fatty acids Kaposi sarcoma-associated herpesvirus infection -0.752173913 0 -0.407207207 kegg kegg NA NA no no no no no dn Butanoate metabolism Kaposi sarcoma-associated herpesvirus infection -0.473043478 0 0 kegg kegg NA NA no no no no no dn Calcium signaling pathway Kaposi sarcoma-associated herpesvirus infection 0.462608696 0 0 kegg kegg NA NA no up up no no dn cAMP signaling pathway Kaposi sarcoma-associated herpesvirus infection 0.526956522 0.555335968 0 yes kegg kegg NA NA no up up no no dn Carbohydrate digestion and absorption Kaposi sarcoma-associated herpesvirus infection 0 0 -0.622908623 kegg kegg NA NA no no no no no dn Cardiac muscle contraction Kaposi sarcoma-associated herpesvirus infection 0 0.418972332 0 kegg kegg NA NA no no up no no dn Chagas disease Kaposi sarcoma-associated herpesvirus infection 0.471304348 0 0 kegg kegg NA NA no no no no no dn Cholesterol metabolism Kaposi sarcoma-associated herpesvirus infection 0.428695652 0 0 yes kegg kegg NA NA no no up no no dn Cholinergic synapse Kaposi sarcoma-associated herpesvirus infection 0 -0.538537549 -0.505534106 kegg kegg NA NA no no no no no dn Citrate cycle (TCA cycle) Kaposi sarcoma-associated herpesvirus infection -0.599130435 0 0 kegg kegg NA NA no no no no no dn Cocaine addiction Kaposi sarcoma-associated herpesvirus infection 0.670434783 0 0.5003861 kegg kegg NA NA no no no no no dn Cortisol synthesis and secretion Kaposi sarcoma-associated herpesvirus infection 0.58 0 0 kegg kegg NA NA no no up no no dn Cushing syndrome Kaposi sarcoma-associated herpesvirus infection 0.437391304 0 0 kegg kegg NA NA no no up no no dn Cysteine and methionine metabolism Kaposi sarcoma-associated herpesvirus infection -0.423478261 0 0 kegg kegg NA NA no no no no no dn Cytosolic DNA-sensing pathway Kaposi sarcoma-associated herpesvirus infection 0.513043478 0.584980237 0.466409266 kegg kegg NA NA no no no no no dn DNA replication Kaposi sarcoma-associated herpesvirus infection -0.548695652 0 0 kegg kegg NA NA no no no no no dn Dopaminergic synapse Kaposi sarcoma-associated herpesvirus infection 0.47826087 0 0 kegg kegg NA NA no up no no no dn Drug metabolism - other enzymes Kaposi sarcoma-associated herpesvirus infection -0.444347826 0 0 kegg kegg NA NA no no no no no dn ECM-receptor interaction Kaposi sarcoma-associated herpesvirus infection 0 -0.425889328 0 kegg kegg NA NA no up up no no dn ErbB signaling pathway Kaposi sarcoma-associated herpesvirus infection 0 0 -0.564221364 kegg kegg NA NA no no no no no dn Estrogen signaling pathway Kaposi sarcoma-associated herpesvirus infection -0.413043478 0 0 kegg kegg NA NA no no no no no dn Fanconi anemia pathway Kaposi sarcoma-associated herpesvirus infection -0.545217391 -0.420948617 0 kegg kegg NA NA no no no no no dn Fatty acid degradation Kaposi sarcoma-associated herpesvirus infection -0.650434783 0 0 kegg kegg NA NA no no no no no dn Fatty acid elongation Kaposi sarcoma-associated herpesvirus infection -0.675652174 0 0 kegg kegg NA NA no no no no no dn Fatty acid metabolism Kaposi sarcoma-associated herpesvirus infection -0.677391304 0 0 kegg kegg NA NA no no no no no dn Fc epsilon RI signaling pathway Kaposi sarcoma-associated herpesvirus infection 0 0 -0.442728443 kegg kegg NA NA no no no no no dn Fc gamma R-mediated phagocytosis Kaposi sarcoma-associated herpesvirus infection -0.607826087 0 0 kegg kegg NA NA no no no no no dn Ferroptosis Kaposi sarcoma-associated herpesvirus infection 0.616521739 0.616600791 0.748519949 kegg kegg NA NA no no no no no dn FoxO signaling pathway Kaposi sarcoma-associated herpesvirus infection 0 0 -0.501158301 kegg kegg NA NA no no no no no dn Galactose metabolism Kaposi sarcoma-associated herpesvirus infection -0.548695652 -0.469367589 0 kegg kegg NA NA no no no no no dn Glutathione metabolism Kaposi sarcoma-associated herpesvirus infection 0 0 0.563706564 kegg kegg NA NA no no no no no dn Glycerolipid metabolism Kaposi sarcoma-associated herpesvirus infection 0 0 -0.474646075 kegg kegg NA NA no no up no no dn Glycerophospholipid metabolism Kaposi sarcoma-associated herpesvirus infection 0 0 -0.492664093 kegg kegg NA NA no no up no no dn "Glycine, serine and threonine metabolism" Kaposi sarcoma-associated herpesvirus infection 0 0 0.527927928 kegg kegg NA NA no up no no no dn Glycolysis / Gluconeogenesis Kaposi sarcoma-associated herpesvirus infection -0.429565217 0 0 kegg kegg NA NA no no no no no dn Glycosaminoglycan biosynthesis - heparan sulfate / heparin Kaposi sarcoma-associated herpesvirus infection 0 -0.496047431 -0.437065637 kegg kegg NA NA no no no no no dn Glycosaminoglycan degradation Kaposi sarcoma-associated herpesvirus infection 0 0 -0.458172458 kegg kegg NA NA no no up no no dn Glycosphingolipid biosynthesis - ganglio series Kaposi sarcoma-associated herpesvirus infection 0 -0.461462451 0 kegg kegg NA NA no no no no no dn GnRH secretion Kaposi sarcoma-associated herpesvirus infection 0 0 -0.55006435 kegg kegg NA NA no up up no no dn GnRH signaling pathway Kaposi sarcoma-associated herpesvirus infection 0.512173913 0 0 kegg kegg NA NA no no no no no dn Hedgehog signaling pathway Kaposi sarcoma-associated herpesvirus infection 0 -0.475296443 0 kegg kegg NA NA no no no no no dn Hematopoietic cell lineage Kaposi sarcoma-associated herpesvirus infection -0.446086957 -0.476284585 -0.4002574 kegg kegg NA NA no no no no no dn Hepatitis C Kaposi sarcoma-associated herpesvirus infection 0 0.459486166 0 kegg kegg NA NA no no no no no dn Hippo signaling pathway - multiple species Kaposi sarcoma-associated herpesvirus infection 0 0 -0.55032175 kegg kegg NA NA no no no no no dn Histidine metabolism Kaposi sarcoma-associated herpesvirus infection -0.680869565 -0.48715415 -0.532561133 kegg kegg NA NA no no no no no dn Homologous recombination Kaposi sarcoma-associated herpesvirus infection -0.546956522 0 0 kegg kegg NA NA no no no no no dn Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection 0 0.529644269 0 kegg kegg NA NA no no dn no no dn Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection 0 0.496047431 0 kegg kegg NA NA no no no no no dn Huntington disease Kaposi sarcoma-associated herpesvirus infection 0 0.471343874 0 kegg kegg NA NA no no no no no dn Inositol phosphate metabolism Kaposi sarcoma-associated herpesvirus infection -0.513043478 -0.480237154 -0.62985843 kegg kegg NA NA no no no no no dn Insulin secretion Kaposi sarcoma-associated herpesvirus infection 0.496521739 0 0 yes kegg kegg NA NA no up up no no dn Long-term depression Kaposi sarcoma-associated herpesvirus infection 0.551304348 0.453557312 0 kegg kegg NA NA no no no no no dn Longevity regulating pathway Kaposi sarcoma-associated herpesvirus infection 0.575652174 0 0.567567568 kegg kegg NA NA no no no no no dn Longevity regulating pathway - multiple species Kaposi sarcoma-associated herpesvirus infection -0.70173913 0 0 kegg kegg NA NA no no no no no dn Lysine degradation Kaposi sarcoma-associated herpesvirus infection 0 0 -0.407722008 kegg kegg NA NA no no no no no dn Malaria Kaposi sarcoma-associated herpesvirus infection 0.452173913 0.690711462 0.835006435 kegg kegg NA NA no no no no no dn Mannose type O-glycan biosynthesis Kaposi sarcoma-associated herpesvirus infection 0.449565217 0 0 kegg kegg NA NA no no no no no dn MAPK signaling pathway Kaposi sarcoma-associated herpesvirus infection -0.497391304 -0.602766798 -0.483397683 kegg kegg NA NA no no no no no dn Mineral absorption Kaposi sarcoma-associated herpesvirus infection 0.722608696 0.638339921 0.767567568 kegg kegg NA NA no no no no no dn Mismatch repair Kaposi sarcoma-associated herpesvirus infection -0.72 0 0 kegg kegg NA NA no no no no no dn Mitophagy - animal Kaposi sarcoma-associated herpesvirus infection 0.812173913 0.616600791 0.87953668 kegg kegg NA NA no no no no no dn Morphine addiction Kaposi sarcoma-associated herpesvirus infection 0.56 0 0 kegg kegg NA NA no up up no no dn Mucin type O-glycan biosynthesis Kaposi sarcoma-associated herpesvirus infection -0.46 -0.477272727 0 kegg kegg NA NA no no no no no dn Necroptosis Kaposi sarcoma-associated herpesvirus infection 0.646956522 0.712450593 0.738223938 kegg kegg NA NA no no no no no dn Neuroactive ligand-receptor interaction Kaposi sarcoma-associated herpesvirus infection -0.493913043 0 0 kegg kegg NA NA up up up no no dn Neurotrophin signaling pathway Kaposi sarcoma-associated herpesvirus infection 0.550434783 0 0 kegg kegg NA NA no no no no no dn Non-alcoholic fatty liver disease Kaposi sarcoma-associated herpesvirus infection 0.407826087 0.574110672 0 kegg kegg NA NA no no no no no dn Non-homologous end-joining Kaposi sarcoma-associated herpesvirus infection -0.58 -0.434782609 0 kegg kegg NA NA no no no no no dn Notch signaling pathway Kaposi sarcoma-associated herpesvirus infection 0 0 -0.534105534 kegg kegg NA NA no no no no no dn Nucleotide excision repair Kaposi sarcoma-associated herpesvirus infection -0.588695652 0 0 kegg kegg NA NA no no no no no dn Olfactory transduction Kaposi sarcoma-associated herpesvirus infection -0.53826087 0 0 kegg kegg NA NA no no no no no dn One carbon pool by folate Kaposi sarcoma-associated herpesvirus infection -0.569565217 -0.502964427 0 kegg kegg NA NA no no no no no dn Other glycan degradation Kaposi sarcoma-associated herpesvirus infection 0 0 -0.5997426 kegg kegg NA NA no no no no no dn Other types of O-glycan biosynthesis Kaposi sarcoma-associated herpesvirus infection 0 0 -0.500643501 kegg kegg NA NA no no no no no dn Ovarian steroidogenesis Kaposi sarcoma-associated herpesvirus infection 0 0 0.431917632 kegg kegg NA NA no up up no no dn Oxidative phosphorylation Kaposi sarcoma-associated herpesvirus infection 0 0.445652174 0 kegg kegg NA NA no no no no no dn Pancreatic secretion Kaposi sarcoma-associated herpesvirus infection 0.572173913 0 0 kegg kegg NA NA no no no no no dn Pantothenate and CoA biosynthesis Kaposi sarcoma-associated herpesvirus infection -0.480869565 0 0 kegg kegg NA NA no no dn no no dn "Parathyroid hormone synthesis, secretion and action" Kaposi sarcoma-associated herpesvirus infection 0.664347826 0.479249012 0.471042471 kegg kegg NA NA no no no no no dn Parkinson disease Kaposi sarcoma-associated herpesvirus infection 0.675652174 0.553359684 0.760617761 kegg kegg NA NA no no no no no dn Pathways of neurodegeneration - multiple diseases Kaposi sarcoma-associated herpesvirus infection 0.671304348 0.545454545 0.764736165 kegg kegg NA NA no no no no no dn Pentose and glucuronate interconversions Kaposi sarcoma-associated herpesvirus infection -0.532173913 0 0 kegg kegg NA NA no no no no no dn Peroxisome Kaposi sarcoma-associated herpesvirus infection -0.539130435 0 0 kegg kegg NA NA no no no no no dn Phenylalanine metabolism Kaposi sarcoma-associated herpesvirus infection -0.431304348 -0.460474308 0 kegg kegg NA NA no no no no no dn Phosphatidylinositol signaling system Kaposi sarcoma-associated herpesvirus infection 0 -0.510869565 -0.51016731 kegg kegg NA NA no no no no no dn Platinum drug resistance Kaposi sarcoma-associated herpesvirus infection 0 -0.461462451 -0.479021879 kegg kegg NA NA no no no no no dn Porphyrin and chlorophyll metabolism Kaposi sarcoma-associated herpesvirus infection 0 0 0.605920206 kegg kegg NA NA no no no no no dn Primary bile acid biosynthesis Kaposi sarcoma-associated herpesvirus infection -0.788695652 0 0 kegg kegg NA NA no no no no no dn Progesterone-mediated oocyte maturation Kaposi sarcoma-associated herpesvirus infection 0 -0.434782609 -0.605662806 kegg kegg NA NA no no no no no dn Propanoate metabolism Kaposi sarcoma-associated herpesvirus infection -0.47826087 0 0 kegg kegg NA NA no no no no no dn Protein digestion and absorption Kaposi sarcoma-associated herpesvirus infection -0.513043478 0 -0.479279279 yes kegg kegg NA NA no up up no no dn Protein processing in endoplasmic reticulum Kaposi sarcoma-associated herpesvirus infection 0 0 0.557014157 kegg kegg NA NA no no no no no dn Purine metabolism Kaposi sarcoma-associated herpesvirus infection 0 0 0.715315315 kegg kegg NA NA no no no no no dn Pyrimidine metabolism Kaposi sarcoma-associated herpesvirus infection -0.555652174 0 0 kegg kegg NA NA no no no no no dn Pyruvate metabolism Kaposi sarcoma-associated herpesvirus infection -0.60173913 0 0 kegg kegg NA NA no no no no no dn Ras signaling pathway Kaposi sarcoma-associated herpesvirus infection 0 0 -0.416216216 yes kegg kegg NA NA no up up no no dn Regulation of lipolysis in adipocytes Kaposi sarcoma-associated herpesvirus infection 0.431304348 0 0 kegg kegg NA NA no no no no no dn Relaxin signaling pathway Kaposi sarcoma-associated herpesvirus infection 0.775652174 0.423913043 0.427284427 kegg kegg NA NA no no no no no dn Retinol metabolism Kaposi sarcoma-associated herpesvirus infection -0.690434783 -0.632411067 -0.534105534 kegg kegg NA NA no no no no no dn Ribosome Kaposi sarcoma-associated herpesvirus infection 0.535652174 0.429841897 0.477477477 kegg kegg NA NA no no no no no dn Salmonella infection Kaposi sarcoma-associated herpesvirus infection -0.455652174 0 0 kegg kegg NA NA no no no no no dn Selenocompound metabolism Kaposi sarcoma-associated herpesvirus infection 0 -0.529644269 -0.515572716 kegg kegg NA NA no no no no no dn Shigellosis Kaposi sarcoma-associated herpesvirus infection 0.793913043 0.783596838 0.896010296 kegg kegg NA NA no no no no no dn Signaling pathways regulating pluripotency of stem cells Kaposi sarcoma-associated herpesvirus infection 0 0 -0.453281853 kegg kegg NA NA no no no no no dn Sphingolipid metabolism Kaposi sarcoma-associated herpesvirus infection 0 0 -0.476705277 kegg kegg NA NA no no no no no dn Sphingolipid signaling pathway Kaposi sarcoma-associated herpesvirus infection 0 0 -0.723552124 kegg kegg NA NA no no no no no dn Staphylococcus aureus infection Kaposi sarcoma-associated herpesvirus infection -0.437391304 0 0 kegg kegg NA NA up no no no no dn Steroid hormone biosynthesis Kaposi sarcoma-associated herpesvirus infection -0.572173913 -0.581027668 -0.465637066 kegg kegg NA NA no no no no no dn Sulfur metabolism Kaposi sarcoma-associated herpesvirus infection 0 0 0.486229086 kegg kegg NA NA no no no no no dn Synthesis and degradation of ketone bodies Kaposi sarcoma-associated herpesvirus infection -0.651304348 -0.446640316 0 kegg kegg NA NA no no no no no dn Taste transduction Kaposi sarcoma-associated herpesvirus infection -0.44173913 0 -0.50965251 kegg kegg NA NA no no up no no dn Terpenoid backbone biosynthesis Kaposi sarcoma-associated herpesvirus infection -0.437391304 0 0 kegg kegg NA NA no no no no no dn TGF-beta signaling pathway Kaposi sarcoma-associated herpesvirus infection 0 0 -0.492921493 kegg kegg NA NA no no no no no dn Thyroid hormone synthesis Kaposi sarcoma-associated herpesvirus infection 0.50173913 0 0.574774775 kegg kegg NA NA no no no no no dn TNF signaling pathway Kaposi sarcoma-associated herpesvirus infection 0.588695652 0 0 kegg kegg NA NA no no no no no dn Toxoplasmosis Kaposi sarcoma-associated herpesvirus infection -0.500869565 0 0 kegg kegg NA NA no no no no no dn Tryptophan metabolism Kaposi sarcoma-associated herpesvirus infection -0.675652174 -0.488142292 0 kegg kegg NA NA no up no no no dn Tuberculosis Kaposi sarcoma-associated herpesvirus infection -0.500869565 0 0 kegg kegg NA NA no no dn no no dn Type II diabetes mellitus Kaposi sarcoma-associated herpesvirus infection 0 0 -0.543886744 kegg kegg NA NA no no no no no dn Tyrosine metabolism Kaposi sarcoma-associated herpesvirus infection -0.612173913 -0.436758893 0 kegg kegg NA NA no no no no no dn Ubiquinone and other terpenoid-quinone biosynthesis Kaposi sarcoma-associated herpesvirus infection -0.713043478 -0.580039526 0 kegg kegg NA NA no no no no no dn Ubiquitin mediated proteolysis Kaposi sarcoma-associated herpesvirus infection 0.74 0.516798419 0.863835264 kegg kegg NA NA no no no no no dn "Valine, leucine and isoleucine degradation" Kaposi sarcoma-associated herpesvirus infection -0.655652174 -0.481225296 0 kegg kegg NA NA no no no no no dn Various types of N-glycan biosynthesis Kaposi sarcoma-associated herpesvirus infection 0 0 -0.488030888 kegg kegg NA NA no no no no no dn Vascular smooth muscle contraction Kaposi sarcoma-associated herpesvirus infection 0.553043478 0 0 kegg kegg NA NA no no no no no dn VEGF signaling pathway Kaposi sarcoma-associated herpesvirus infection 0 0 -0.546460746 kegg kegg NA NA no no no no no dn Vitamin digestion and absorption Kaposi sarcoma-associated herpesvirus infection 0 -0.5 -0.462033462 kegg kegg NA NA no no no no no dn Wnt signaling pathway Kaposi sarcoma-associated herpesvirus infection 0 0 -0.428056628 kegg kegg NA NA no no no no no dn 5-Hydroxytryptamine+stool Kynurenic acid+stool 0 0.594405594 0 stool_cometabolism stool_cometabolism 0.00862 0.037 dn dn no dn dn no ACA+stool Kynurenic acid+stool 0 -0.650443636 0 stool_bileacids stool_cometabolism 0.417 0.037 no no no dn dn no CA+stool Kynurenic acid+stool 0 0 -0.537549407 stool_bileacids stool_cometabolism 0.827 0.037 no no no dn dn no Indole-3-Acetic acid+stool Kynurenic acid+stool 0 0.608391608 0 stool_cometabolism stool_cometabolism 0.304 0.037 no no no dn dn no 2-hydroxyphenylacetic acid+urine Kynurenic acid+urine 0 0 -0.409230769 urine_cometabolism urine_cometabolism 0.763 0.296 no no no no no no 4-Hydroxyphenylacetic acid+urine Kynurenic acid+urine 0 -0.473684211 -0.443418803 urine_cometabolism urine_cometabolism 0.0321 0.296 up up no no no no 5-Hydroxyindole-3-acetic Acid+urine Kynurenic acid+urine 0 0.670175439 0.514529915 urine_cometabolism urine_cometabolism 0.0405 0.296 no dn dn no no no DL-Indole-3-lactic acid+urine Kynurenic acid+urine 0 0 -0.402393162 urine_cometabolism urine_cometabolism 0.00552 0.296 up up no no no no 14:0-LPC+blood L-2-Aminobutyric acid+blood -0.482706767 -0.539215686 0 yes serum_phospholipids serum_aminoacids 0.00689 0.000328 up up no up up no 14:0/18:0-PC+blood L-2-Aminobutyric acid+blood 0 -0.50245098 0 yes serum_phospholipids serum_aminoacids 0.00289 0.000328 up up no up up no 14:1/18:2-PG+blood L-2-Aminobutyric acid+blood 0 -0.526960784 0 yes serum_phospholipids serum_aminoacids 0.00259 0.000328 no up up up up no 16:0-LPE+blood L-2-Aminobutyric acid+blood 0 0 -0.446153846 yes serum_phospholipids serum_aminoacids 0.0711 0.000328 up up no up up no 16:0/16:0-PI+blood L-2-Aminobutyric acid+blood 0 -0.487745098 0 yes serum_phospholipids serum_aminoacids 0.358 0.000328 no no no up up no 16:0/16:1-PI+blood L-2-Aminobutyric acid+blood -0.604511278 -0.49754902 0 yes serum_phospholipids serum_aminoacids 0.262 0.000328 no no no up up no 16:0/18:1-PE+blood L-2-Aminobutyric acid+blood 0 0 -0.473504274 yes serum_phospholipids serum_aminoacids 0.000107 0.000328 up up no up up no 16:0/18:2-PI+blood L-2-Aminobutyric acid+blood -0.54887218 -0.779411765 0 yes serum_phospholipids serum_aminoacids 0.269 0.000328 no no no up up no 16:0/20:4-PC+blood L-2-Aminobutyric acid+blood 0 0.715686275 0 yes serum_phospholipids serum_aminoacids 0.0262 0.000328 no up no up up no 16:0/20:4-PI+blood L-2-Aminobutyric acid+blood -0.458646617 -0.588235294 0 yes serum_phospholipids serum_aminoacids 0.558 0.000328 no no no up up no 16:0/22:0-PE+blood L-2-Aminobutyric acid+blood 0.464661654 0 0 yes serum_phospholipids serum_aminoacids 0.00839 0.000328 dn no up up up no 16:0/22:6-PC+blood L-2-Aminobutyric acid+blood 0.54887218 0.602941176 0 yes serum_phospholipids serum_aminoacids 4.53E-05 0.000328 no up up up up no 16:0/22:6-PE+blood L-2-Aminobutyric acid+blood 0 0 -0.417435897 yes serum_phospholipids serum_aminoacids 0.000934 0.000328 up up no up up no 16:1/16:0-PC+blood L-2-Aminobutyric acid+blood 0 0.492647059 0 yes serum_phospholipids serum_aminoacids 0.0215 0.000328 no up up up up no 16:1/16:1-PC+blood L-2-Aminobutyric acid+blood 0 0.492647059 0 yes serum_phospholipids serum_aminoacids 0.0177 0.000328 no no up up up no 18:0/18:0-PC+blood L-2-Aminobutyric acid+blood 0 0 0.549401709 yes serum_phospholipids serum_aminoacids 0.426 0.000328 no no no up up no 18:0/18:1-PC+blood L-2-Aminobutyric acid+blood 0 0 0.537777778 yes serum_phospholipids serum_aminoacids 0.393 0.000328 no no no up up no 18:0/20:2-PC+blood L-2-Aminobutyric acid+blood 0 -0.531862745 0 yes serum_phospholipids serum_aminoacids 0.733 0.000328 no no no up up no 18:0/20:4-PC+blood L-2-Aminobutyric acid+blood 0 0.580882353 0 yes serum_phospholipids serum_aminoacids 0.454 0.000328 no no no up up no 18:0/20:5-PC+blood L-2-Aminobutyric acid+blood 0.509774436 0.551470588 0 yes serum_phospholipids serum_aminoacids 0.17 0.000328 no no no up up no 18:0/22:6-PE+blood L-2-Aminobutyric acid+blood 0 0 -0.470769231 yes serum_phospholipids serum_aminoacids 0.00022 0.000328 up up no up up no 18:1/16:0-PE+blood L-2-Aminobutyric acid+blood -0.461654135 0 -0.452307692 yes serum_phospholipids serum_aminoacids 0.000182 0.000328 up up no up up no 18:1/16:1-PE+blood L-2-Aminobutyric acid+blood 0 -0.522058824 0 yes serum_phospholipids serum_aminoacids 0.000184 0.000328 up up no up up no 18:1/18:0-PE+blood L-2-Aminobutyric acid+blood 0 -0.625 -0.455726496 yes serum_phospholipids serum_aminoacids 1.39E-06 0.000328 up up no up up no 18:1/18:1-PE+blood L-2-Aminobutyric acid+blood 0 -0.566176471 0 yes serum_phospholipids serum_aminoacids 1.03E-05 0.000328 up up no up up no 18:1/18:2-PE+blood L-2-Aminobutyric acid+blood 0 -0.666666667 0 yes serum_phospholipids serum_aminoacids 0.000293 0.000328 up up no up up no 18:1/20:4-PC+blood L-2-Aminobutyric acid+blood 0.473684211 0 0 yes serum_phospholipids serum_aminoacids 0.582 0.000328 no no no up up no 18:3/16:0-PE+blood L-2-Aminobutyric acid+blood 0 -0.495098039 -0.414700855 yes serum_phospholipids serum_aminoacids 0.00149 0.000328 up up no up up no 18:3n3+blood L-2-Aminobutyric acid+blood 0 0.56127451 0 yes serum_fattyacid serum_aminoacids 0.291 0.000328 no no no up up no 18:3n6+blood L-2-Aminobutyric acid+blood -0.514285714 0 0 yes serum_fattyacid serum_aminoacids 0.0463 0.000328 up no dn up up no 20:0-LPE+blood L-2-Aminobutyric acid+blood -0.55037594 -0.482843137 0 yes serum_phospholipids serum_aminoacids 0.0615 0.000328 no no up up up no 20:0/20:4-PE+blood L-2-Aminobutyric acid+blood 0 -0.715686275 0 yes serum_phospholipids serum_aminoacids 0.00128 0.000328 up up no up up no 20:0/20:5-PC+blood L-2-Aminobutyric acid+blood 0.476691729 0 0 yes serum_phospholipids serum_aminoacids 0.882 0.000328 no no no up up no 20:2/18:1-PE+blood L-2-Aminobutyric acid+blood 0 -0.637254902 0 yes serum_phospholipids serum_aminoacids 0.00208 0.000328 up up no up up no 20:3/16:0-PC+blood L-2-Aminobutyric acid+blood 0 0.691176471 0 yes serum_phospholipids serum_aminoacids 0.00405 0.000328 no up up up up no 20:3/18:0-PC+blood L-2-Aminobutyric acid+blood 0 0.482843137 0 yes serum_phospholipids serum_aminoacids 0.296 0.000328 no no no up up no 20:4-LPC+blood L-2-Aminobutyric acid+blood 0 0.539215686 0 yes serum_phospholipids serum_aminoacids 0.949 0.000328 no no no up up no 20:4/16:0-PE+blood L-2-Aminobutyric acid+blood 0 0 -0.40034188 yes serum_phospholipids serum_aminoacids 0.00529 0.000328 no up up up up no 20:5/18:0-PC+blood L-2-Aminobutyric acid+blood 0.565413534 0.612745098 0 yes serum_phospholipids serum_aminoacids 3.97E-06 0.000328 no up up up up no 22:0/16:0-PE+blood L-2-Aminobutyric acid+blood 0.544360902 0 0 yes serum_phospholipids serum_aminoacids 0.091 0.000328 no no up up up no 22:6-LPC+blood L-2-Aminobutyric acid+blood 0 0.68872549 0 yes serum_phospholipids serum_aminoacids 0.127 0.000328 no no up up up no 5-HETE+blood L-2-Aminobutyric acid+blood 0.541135928 0 0 yes serum_ARA serum_aminoacids 0.697 0.000328 no no no up up no AA+blood L-2-Aminobutyric acid+blood 0 0.806372549 0 yes serum_ARA serum_aminoacids 0.212 0.000328 no no no up up no acetic acid C2+blood L-2-Aminobutyric acid+blood 0.45112782 0 0 yes serum_scfa serum_aminoacids 0.000193 0.000328 up dn no up up no Amoebiasis L-2-Aminobutyric acid+blood 0.526315789 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no Anaerostipes L-2-Aminobutyric acid+blood 0 0.528252371 0 butyrate-producing yes Genus serum_aminoacids 0.568 0.000328 no no no up up no Apelin signaling pathway L-2-Aminobutyric acid+blood -0.498245614 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no Axon guidance L-2-Aminobutyric acid+blood 0 -0.8 0 yes kegg serum_aminoacids NA 0.000328 no up up up up no Biosynthesis of cofactors L-2-Aminobutyric acid+blood -0.547368421 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no CDCA+blood L-2-Aminobutyric acid+blood -0.445112782 0 0 yes serum_bileacids serum_aminoacids 0.506 0.000328 no no no up up no Cell adhesion molecules L-2-Aminobutyric acid+blood 0 0 -0.405384615 yes kegg serum_aminoacids NA 0.000328 no no no up up no Creatinine+blood L-2-Aminobutyric acid+blood 0.467669173 0 0 yes serum_choline serum_aminoacids 0.437 0.000328 no no no up up no Cysteine+blood L-2-Aminobutyric acid+blood 0 0 0.501538462 yes yes serum_aminoacids serum_aminoacids 1.81E-07 0.000328 dn up up up up no Cystine+blood L-2-Aminobutyric acid+blood 0 0 0.568547009 yes yes serum_aminoacids serum_aminoacids 0.00028 0.000328 up up no up up no DHA+blood L-2-Aminobutyric acid+blood 0 0.838235294 -0.496752137 yes serum_ARA serum_aminoacids 0.872 0.000328 no no no up up no Dilated cardiomyopathy L-2-Aminobutyric acid+blood 0 0 -0.42 yes kegg serum_aminoacids NA 0.000328 no up up up up no EGFR tyrosine kinase inhibitor resistance L-2-Aminobutyric acid+blood -0.603508772 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no EPA+blood L-2-Aminobutyric acid+blood 0 0.605392157 0 yes serum_ARA serum_aminoacids 0.212 0.000328 no no no up up no Fc epsilon RI signaling pathway L-2-Aminobutyric acid+blood 0.492982456 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no GCA+stool L-2-Aminobutyric acid+blood 0 0 0.533834586 yes stool_bileacids serum_aminoacids 0.0809 0.000328 no no no up up no "Glycine, serine and threonine metabolism" L-2-Aminobutyric acid+blood -0.49122807 0 0 yes kegg serum_aminoacids NA 0.000328 no up no up up no HCA+blood L-2-Aminobutyric acid+blood -0.499853957 0 0 yes serum_bileacids serum_aminoacids 0.544 0.000328 no no no up up no HDCA+stool L-2-Aminobutyric acid+blood 0 0.636363636 0 yes stool_bileacids serum_aminoacids 0.176 0.000328 no no no up up no HIF-1 signaling pathway L-2-Aminobutyric acid+blood -0.585964912 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no Human papillomavirus infection L-2-Aminobutyric acid+blood 0 0 -0.448461538 yes kegg serum_aminoacids NA 0.000328 no no no up up no IL-17 signaling pathway L-2-Aminobutyric acid+blood 0.549122807 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no Insulin signaling pathway L-2-Aminobutyric acid+blood -0.540350877 0 0.438461538 yes kegg serum_aminoacids NA 0.000328 no no no up up no isocapric acid iso-C6+blood L-2-Aminobutyric acid+blood 0.592481203 0 0 yes serum_scfa serum_aminoacids 0.0458 0.000328 no no dn up up no L-Tryptophan+stool L-2-Aminobutyric acid+blood 0.571428571 0 0 yes stool_cometabolism serum_aminoacids 0.557 0.000328 no no no up up no Legionellosis L-2-Aminobutyric acid+blood -0.561403509 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no Lysosome L-2-Aminobutyric acid+blood 0.575438596 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no Measles L-2-Aminobutyric acid+blood 0 0.508823529 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no Methanobrevibacter L-2-Aminobutyric acid+blood 0 0 0.403322424 yes Genus serum_aminoacids 0.629 0.000328 no no no up up no mTOR signaling pathway L-2-Aminobutyric acid+blood -0.614035088 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no Odoribacter L-2-Aminobutyric acid+blood 0 0 -0.412119208 butyrate-producing yes Genus serum_aminoacids 0.798 0.000328 no no no up up no Phospholipase D signaling pathway L-2-Aminobutyric acid+blood 0.471929825 0 0 yes kegg serum_aminoacids NA 0.000328 no up up up up no PI3K-Akt signaling pathway L-2-Aminobutyric acid+blood -0.60877193 0 0 yes yes kegg serum_aminoacids NA 0.000328 no up up up up no Porphyrin and chlorophyll metabolism L-2-Aminobutyric acid+blood -0.494736842 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no Primary immunodeficiency L-2-Aminobutyric acid+blood 0 0.520588235 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no Proteoglycans in cancer L-2-Aminobutyric acid+blood -0.698245614 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no Ribosome biogenesis in eukaryotes L-2-Aminobutyric acid+blood -0.466666667 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no RNA transport L-2-Aminobutyric acid+blood -0.635087719 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no Sphingolipid signaling pathway L-2-Aminobutyric acid+blood 0.464912281 0 0 yes kegg serum_aminoacids NA 0.000328 no no no up up no Th1 and Th2 cell differentiation L-2-Aminobutyric acid+blood 0 0 0.403846154 yes kegg serum_aminoacids NA 0.000328 no no no up up no total_stool_scfa+stool L-2-Aminobutyric acid+blood -0.582417582 0 0 yes stool_scfa serum_aminoacids 0.0534 0.000328 dn no up up up no Tuberculosis L-2-Aminobutyric acid+blood 0.478947368 0 0 yes kegg serum_aminoacids NA 0.000328 no no dn up up no Viral myocarditis L-2-Aminobutyric acid+blood 0 0 -0.403076923 yes kegg serum_aminoacids NA 0.000328 no no no up up no 12-HEPE+blood L-Alanine+blood 0.445082418 -0.556547714 0 yes serum_ARA serum_aminoacids 0.312 0.00138 no no no up up no 12-ketoDCA+stool L-Alanine+blood 0 0 -0.508270677 yes stool_bileacids serum_aminoacids 0.505 0.00138 no no no up up no 14:0-LPC+blood L-Alanine+blood 0 0 0.462564103 yes serum_phospholipids serum_aminoacids 0.00689 0.00138 up up no up up no 14:0/16:0-PC+blood L-Alanine+blood 0 0 0.405811966 yes serum_phospholipids serum_aminoacids 0.0358 0.00138 no up no up up no 14:0/18:0-PC+blood L-Alanine+blood 0 0 0.40034188 yes serum_phospholipids serum_aminoacids 0.00289 0.00138 up up no up up no 14:0/20:4-PC+blood L-Alanine+blood -0.506766917 0 0 yes serum_phospholipids serum_aminoacids 0.486 0.00138 no no no up up no 16:0/16:0-PI+blood L-Alanine+blood 0 0 0.43042735 yes serum_phospholipids serum_aminoacids 0.358 0.00138 no no no up up no 16:0/16:1-PI+blood L-Alanine+blood 0 0 0.591111111 yes serum_phospholipids serum_aminoacids 0.262 0.00138 no no no up up no 16:0/18:2-PI+blood L-Alanine+blood 0 0 0.602051282 yes serum_phospholipids serum_aminoacids 0.269 0.00138 no no no up up no 16:0/18:3-PC+blood L-Alanine+blood 0 0 0.591111111 yes serum_phospholipids serum_aminoacids 0.00216 0.00138 no up up up up no 16:0/20:4-PI+blood L-Alanine+blood 0 0 0.58017094 yes serum_phospholipids serum_aminoacids 0.558 0.00138 no no no up up no 16:1-LPC+blood L-Alanine+blood 0 0 0.447521368 yes serum_phospholipids serum_aminoacids 0.0241 0.00138 no up no up up no 18:0/18:0-PS+blood L-Alanine+blood -0.452631579 0 0 yes serum_phospholipids serum_aminoacids 0.00617 0.00138 no up no up up no 18:0/18:1-PC+blood L-Alanine+blood 0 0 0.414700855 yes serum_phospholipids serum_aminoacids 0.393 0.00138 no no no up up no 18:0/18:2-PI+blood L-Alanine+blood 0 0 0.597264957 yes serum_phospholipids serum_aminoacids 0.179 0.00138 no no no up up no 18:0/20:3-PC+blood L-Alanine+blood -0.485714286 0 0.465299145 yes serum_phospholipids serum_aminoacids 0.0682 0.00138 no up no up up no 18:0/22:6-PA+blood L-Alanine+blood -0.544360902 -0.49754902 0 yes serum_phospholipids serum_aminoacids 0.22 0.00138 no no no up up no 18:1/16:0-PI+blood L-Alanine+blood 0 0 0.528888889 yes serum_phospholipids serum_aminoacids 0.793 0.00138 no no no up up no 18:1/18:0-PI+blood L-Alanine+blood 0 -0.509803922 0.552136752 yes serum_phospholipids serum_aminoacids 0.0931 0.00138 no no up up up no 18:1/18:0-PS+blood L-Alanine+blood -0.661654135 0 0 yes serum_phospholipids serum_aminoacids 0.193 0.00138 no no no up up no 18:1/22:6-PE+blood L-Alanine+blood 0 0 -0.568547009 yes serum_phospholipids serum_aminoacids 0.0047 0.00138 no up no up up no 18:2/18:2-PS+blood L-Alanine+blood -0.484210526 0 0 yes serum_phospholipids serum_aminoacids 0.00674 0.00138 up up no up up no 18:3n6+blood L-Alanine+blood 0 0 0.485128205 yes serum_fattyacid serum_aminoacids 0.0463 0.00138 up no dn up up no 20:0-LPE+blood L-Alanine+blood 0 -0.549019608 0 yes serum_phospholipids serum_aminoacids 0.0615 0.00138 no no up up up no 20:0+blood L-Alanine+blood 0 -0.482843137 0.446837607 yes yes serum_fattyacid serum_aminoacids 0.000278 0.00138 dn no up up up no 20:2-LPE+blood L-Alanine+blood 0 -0.566176471 0 yes serum_phospholipids serum_aminoacids 0.177 0.00138 no no no up up no 20:2/18:0-PC+blood L-Alanine+blood -0.478195489 0 0.455726496 yes serum_phospholipids serum_aminoacids 0.0427 0.00138 no up no up up no 20:3-LPC+blood L-Alanine+blood 0 0 0.448205128 yes serum_phospholipids serum_aminoacids 0.0292 0.00138 no up no up up no 22:2-LPA+blood L-Alanine+blood 0 0 0.42974359 yes serum_phospholipids serum_aminoacids 0.0443 0.00138 dn no no up up no acetic acid C2+blood L-Alanine+blood 0 0 -0.437264957 yes serum_scfa serum_aminoacids 0.000193 0.00138 up dn no up up no Adipocytokine signaling pathway L-Alanine+blood 0.475438596 0 0 yes kegg serum_aminoacids NA 0.00138 no no no up up no Akkermansia L-Alanine+blood 0 0 -0.482162677 acetate-producing yes Genus serum_aminoacids 0.23 0.00138 no no no up up no Biosynthesis of amino acids L-Alanine+blood 0 0 -0.434615385 yes kegg serum_aminoacids NA 0.00138 no no no up up no Calcium signaling pathway L-Alanine+blood 0 0 0.493846154 yes kegg serum_aminoacids NA 0.00138 no up up up up no capric acid C6+blood L-Alanine+blood 0 0 -0.615726496 yes serum_scfa serum_aminoacids 0.433 0.00138 no no no up up no Carbon metabolism L-Alanine+blood 0 0 -0.516153846 yes kegg serum_aminoacids NA 0.00138 no no no up up no Cell cycle L-Alanine+blood -0.494736842 0 0 yes kegg serum_aminoacids NA 0.00138 no no no up up no Chronic myeloid leukemia L-Alanine+blood 0 0 0.415384615 yes kegg serum_aminoacids NA 0.00138 no no no up up no Circadian entrainment L-Alanine+blood 0 0.520588235 0 yes kegg serum_aminoacids NA 0.00138 no up up up up no Cocaine addiction L-Alanine+blood 0 0 0.439230769 yes kegg serum_aminoacids NA 0.00138 no no no up up no Cortisol synthesis and secretion L-Alanine+blood 0 0 0.429230769 yes kegg serum_aminoacids NA 0.00138 no no up up up no Creatinine+blood L-Alanine+blood 0 0 -0.491282051 yes serum_choline serum_aminoacids 0.437 0.00138 no no no up up no Cushing syndrome L-Alanine+blood 0 0 0.469230769 yes kegg serum_aminoacids NA 0.00138 no no up up up no Cystine+blood L-Alanine+blood 0.547368421 0.575980392 0 yes yes serum_aminoacids serum_aminoacids 0.00028 0.00138 up up no up up no Cytosolic DNA-sensing pathway L-Alanine+blood 0 0 0.412307692 yes kegg serum_aminoacids NA 0.00138 no no no up up no d18:0-16:0-SM+blood L-Alanine+blood 0 0 0.445470085 yes serum_phospholipids serum_aminoacids 0.202 0.00138 no no no up up no d18:0-24:1-SM+blood L-Alanine+blood 0 0 0.458461538 yes serum_phospholipids serum_aminoacids 0.0609 0.00138 no dn dn up up no d18:1-14:1-SM+blood L-Alanine+blood -0.506766917 0 0 yes serum_phospholipids serum_aminoacids 0.0952 0.00138 no dn no up up no d18:1-16:0-SM+blood L-Alanine+blood 0 0 0.444102564 yes serum_phospholipids serum_aminoacids 0.14 0.00138 no no no up up no d18:1-20:0-SM+blood L-Alanine+blood -0.481203008 0 0 yes serum_phospholipids serum_aminoacids 0.933 0.00138 no no no up up no d18:1-20:1-SM+blood L-Alanine+blood -0.463157895 0 0 yes serum_phospholipids serum_aminoacids 0.0992 0.00138 no no no up up no d18:1-22:1-SM+blood L-Alanine+blood 0 0 0.433162393 yes serum_phospholipids serum_aminoacids 0.222 0.00138 no no no up up no DHA+blood L-Alanine+blood -0.551879699 0 0 yes serum_ARA serum_aminoacids 0.872 0.00138 no no no up up no DL-methionine sulfoxide+blood L-Alanine+blood 0.577443609 0 0 yes serum_aminoacids serum_aminoacids 0.302 0.00138 no no no up up no ErbB signaling pathway L-Alanine+blood 0 -0.541176471 0 yes kegg serum_aminoacids NA 0.00138 no no no up up no Estrogen signaling pathway L-Alanine+blood 0 0 -0.488461538 yes kegg serum_aminoacids NA 0.00138 no no no up up no Faecalibacterium L-Alanine+blood 0 0.573529412 0 butyrate-producing yes Genus serum_aminoacids 0.0039 0.00138 no dn dn up up no Fc gamma R-mediated phagocytosis L-Alanine+blood 0 0 -0.63 yes kegg serum_aminoacids NA 0.00138 no no no up up no FoxO signaling pathway L-Alanine+blood 0 0 -0.422307692 yes kegg serum_aminoacids NA 0.00138 no no no up up no GCA+blood L-Alanine+blood 0.512781955 0 0 yes yes serum_bileacids serum_aminoacids 0.16 0.00138 no no no up up no GCDCA+blood L-Alanine+blood 0.49924812 0.524509804 0 yes serum_bileacids serum_aminoacids 0.31 0.00138 no no no up up no Glycolysis / Gluconeogenesis L-Alanine+blood 0 0 -0.458461538 yes kegg serum_aminoacids NA 0.00138 no no no up up no Hepatitis B L-Alanine+blood 0 0 0.403076923 yes kegg serum_aminoacids NA 0.00138 no no no up up no Insulin resistance L-Alanine+blood 0 0 0.576153846 yes kegg serum_aminoacids NA 0.00138 no no no up up no Longevity regulating pathway - multiple species L-Alanine+blood 0 0 -0.693846154 yes kegg serum_aminoacids NA 0.00138 no no no up up no mRNA surveillance pathway L-Alanine+blood 0 0 0.401538462 yes kegg serum_aminoacids NA 0.00138 no no no up up no Neuroactive ligand-receptor interaction L-Alanine+blood 0 0 -0.493846154 yes kegg serum_aminoacids NA 0.00138 up up up up up no Neurotrophin signaling pathway L-Alanine+blood 0 0 0.505384615 yes kegg serum_aminoacids NA 0.00138 no no no up up no Non-small cell lung cancer L-Alanine+blood 0 -0.535294118 0 yes kegg serum_aminoacids NA 0.00138 no no no up up no Oxytocin signaling pathway L-Alanine+blood 0 0 -0.416923077 yes kegg serum_aminoacids NA 0.00138 no no no up up no Parabacteroides L-Alanine+blood 0 -0.512254902 0 yes Genus serum_aminoacids 4.19E-05 0.00138 no up up up up no Peroxisome L-Alanine+blood 0 0 -0.506923077 yes kegg serum_aminoacids NA 0.00138 no no no up up no Pertussis L-Alanine+blood 0 0 -0.42 yes kegg serum_aminoacids NA 0.00138 no no dn up up no Prevotella L-Alanine+blood 0 0 0.437846365 acetate-producing yes Genus serum_aminoacids 0.287 0.00138 no no no up up no Primary immunodeficiency L-Alanine+blood 0 0 -0.487692308 yes kegg serum_aminoacids NA 0.00138 no no no up up no Prostate cancer L-Alanine+blood 0 0 0.573076923 yes kegg serum_aminoacids NA 0.00138 no no no up up no Relaxin signaling pathway L-Alanine+blood 0 0 0.451538462 yes kegg serum_aminoacids NA 0.00138 no no no up up no Renal cell carcinoma L-Alanine+blood 0 -0.594117647 0 yes kegg serum_aminoacids NA 0.00138 no no no up up no Rheumatoid arthritis L-Alanine+blood 0 0 -0.436153846 yes kegg serum_aminoacids NA 0.00138 no no no up up no RIG-I-like receptor signaling pathway L-Alanine+blood 0 0 0.478461538 yes kegg serum_aminoacids NA 0.00138 no no no up up no Small cell lung cancer L-Alanine+blood 0 0 0.436923077 yes kegg serum_aminoacids NA 0.00138 no no up up up no Sphingolipid signaling pathway L-Alanine+blood 0 -0.561764706 0 yes kegg serum_aminoacids NA 0.00138 no no no up up no Staphylococcus aureus infection L-Alanine+blood 0 0 -0.416153846 yes kegg serum_aminoacids NA 0.00138 up no no up up no Tight junction L-Alanine+blood 0 0 -0.457692308 yes kegg serum_aminoacids NA 0.00138 no no no up up no Tuberculosis L-Alanine+blood 0 0 -0.480769231 yes kegg serum_aminoacids NA 0.00138 no no dn up up no 12-HEPE+blood L-Arginine+blood 0.534582687 -0.665222712 0 serum_ARA serum_aminoacids 0.312 0.316 no no no no no no 12-ketoDCA+blood L-Arginine+blood 0 0 -0.419130731 serum_bileacids serum_aminoacids 0.517 0.316 no no no no no no 16:0-LPE+blood L-Arginine+blood 0 0 -0.416752137 serum_phospholipids serum_aminoacids 0.0711 0.316 up up no no no no 16:0/14:0-PC+blood L-Arginine+blood 0.521804511 0 0.439316239 serum_phospholipids serum_aminoacids 0.0206 0.316 no up up no no no 16:0/18:0-PS+blood L-Arginine+blood -0.521804511 0 0 serum_phospholipids serum_aminoacids 0.377 0.316 no no no no no no 16:0/18:2-PC+blood L-Arginine+blood 0 0 0.424273504 serum_phospholipids serum_aminoacids 3.24E-06 0.316 no up up no no no 16:0/20:3-PC+blood L-Arginine+blood 0.464661654 0 0 serum_phospholipids serum_aminoacids 5.43E-06 0.316 no up up no no no 16:0/20:4-PC+blood L-Arginine+blood 0 0.536764706 0 serum_phospholipids serum_aminoacids 0.0262 0.316 no up no no no no 16:0/22:6-PC+blood L-Arginine+blood 0 0 0.460512821 serum_phospholipids serum_aminoacids 4.53E-05 0.316 no up up no no no 16:1/16:0-PC+blood L-Arginine+blood 0.454135338 0 0.452307692 serum_phospholipids serum_aminoacids 0.0215 0.316 no up up no no no 18:0/18:0-PE+blood L-Arginine+blood -0.538345865 0 0 serum_phospholipids serum_aminoacids 0.00896 0.316 up up no no no no 18:0/18:1-PE+blood L-Arginine+blood -0.62556391 0 0 serum_phospholipids serum_aminoacids 0.00716 0.316 up up no no no no 18:0/18:2-PC+blood L-Arginine+blood 0 0 0.512478632 serum_phospholipids serum_aminoacids 1.74E-06 0.316 no up up no no no 18:1/16:0-PC+blood L-Arginine+blood 0 0 0.416752137 serum_phospholipids serum_aminoacids 2.43E-05 0.316 no up up no no no 18:1/16:0-PE+blood L-Arginine+blood -0.562406015 0 0 serum_phospholipids serum_aminoacids 0.000182 0.316 up up no no no no 18:1/16:1-PE+blood L-Arginine+blood 0 0 -0.401025641 serum_phospholipids serum_aminoacids 0.000184 0.316 up up no no no no 18:1/18:0-PC+blood L-Arginine+blood 0 0 0.523418803 serum_phospholipids serum_aminoacids 1.83E-06 0.316 no up up no no no 18:1/18:0-PE+blood L-Arginine+blood 0 0 -0.438632479 serum_phospholipids serum_aminoacids 1.39E-06 0.316 up up no no no no 18:1/18:0-PI+blood L-Arginine+blood 0 -0.664215686 0 serum_phospholipids serum_aminoacids 0.0931 0.316 no no up no no no 18:1/18:1-PE+blood L-Arginine+blood -0.517293233 0 -0.465299145 serum_phospholipids serum_aminoacids 1.03E-05 0.316 up up no no no no 18:1/18:2-PE+blood L-Arginine+blood 0 -0.509803922 -0.496068376 serum_phospholipids serum_aminoacids 0.000293 0.316 up up no no no no 18:1/18:2-PG+blood L-Arginine+blood 0 -0.50245098 0 serum_phospholipids serum_aminoacids 5.58E-07 0.316 no up up no no no 18:1/20:3-PC+blood L-Arginine+blood 0.455639098 0 0 serum_phospholipids serum_aminoacids 0.00872 0.316 no up up no no no 18:1/20:4-PE+blood L-Arginine+blood -0.494736842 0 -0.446153846 serum_phospholipids serum_aminoacids 0.0578 0.316 up no no no no no 18:2/16:0-PC+blood L-Arginine+blood 0 0 0.473504274 serum_phospholipids serum_aminoacids 8.67E-05 0.316 no up up no no no 18:3/16:0-PE+blood L-Arginine+blood -0.539849624 0 -0.416752137 serum_phospholipids serum_aminoacids 0.00149 0.316 up up no no no no 18:3n6+blood L-Arginine+blood -0.478195489 0 0 serum_fattyacid serum_aminoacids 0.0463 0.316 up no dn no no no 20:0-LPE+blood L-Arginine+blood 0 -0.526960784 0 serum_phospholipids serum_aminoacids 0.0615 0.316 no no up no no no 20:0/20:4-PE+blood L-Arginine+blood -0.493233083 0 0 serum_phospholipids serum_aminoacids 0.00128 0.316 up up no no no no 20:1-LPE+blood L-Arginine+blood 0 0 0.403760684 serum_phospholipids serum_aminoacids 0.465 0.316 no no no no no no 20:2/18:1-PE+blood L-Arginine+blood -0.517293233 0 -0.40991453 serum_phospholipids serum_aminoacids 0.00208 0.316 up up no no no no 20:3/16:0-PC+blood L-Arginine+blood 0 0.490196078 0.432478632 serum_phospholipids serum_aminoacids 0.00405 0.316 no up up no no no 20:4/16:0-PE+blood L-Arginine+blood 0 0 -0.427008547 serum_phospholipids serum_aminoacids 0.00529 0.316 no up up no no no 20:4/18:0-PE+blood L-Arginine+blood -0.488721805 0 0 serum_phospholipids serum_aminoacids 0.000755 0.316 up up no no no no 24:1+blood L-Arginine+blood 0.563909774 0 0.488547009 serum_fattyacid serum_aminoacids 0.00582 0.316 no dn dn no no no AA+blood L-Arginine+blood 0 0.544117647 0 serum_ARA serum_aminoacids 0.212 0.316 no no no no no no Alistipes L-Arginine+blood 0 0 -0.45592035 Genus serum_aminoacids 0.0114 0.316 no up no no no no Apelin signaling pathway L-Arginine+blood 0 0 0.424615385 kegg serum_aminoacids NA 0.316 no no no no no no Axon guidance L-Arginine+blood 0 -0.555882353 0 kegg serum_aminoacids NA 0.316 no up up no no no B cell receptor signaling pathway L-Arginine+blood 0.473684211 0 0 kegg serum_aminoacids NA 0.316 no no no no no no Betaine+blood L-Arginine+blood 0 0 0.422905983 serum_choline serum_aminoacids 0.857 0.316 no no no no no no Chemical carcinogenesis - receptor activation L-Arginine+blood 0 -0.523529412 0 kegg serum_aminoacids NA 0.316 no no no no no no Choline+blood L-Arginine+blood 0.631578947 0 0 serum_choline serum_aminoacids 0.0395 0.316 no up no no no no Coronavirus disease - COVID-19 L-Arginine+blood 0 0 0.506923077 kegg serum_aminoacids NA 0.316 no no no no no no Creatinine+blood L-Arginine+blood 0.687218045 0 0 serum_choline serum_aminoacids 0.437 0.316 no no no no no no Cysteine+blood L-Arginine+blood 0.455639098 0 0 yes serum_aminoacids serum_aminoacids 1.81E-07 0.316 dn up up no no no Cystine+blood L-Arginine+blood 0.44962406 0 0 yes serum_aminoacids serum_aminoacids 0.00028 0.316 up up no no no no d18:0-16:0-SM+blood L-Arginine+blood -0.553383459 0 0 serum_phospholipids serum_aminoacids 0.202 0.316 no no no no no no d18:0-24:1-SM+blood L-Arginine+blood -0.45112782 0 0 serum_phospholipids serum_aminoacids 0.0609 0.316 no dn dn no no no d18:1-14:1-SM+blood L-Arginine+blood 0 0 -0.403760684 serum_phospholipids serum_aminoacids 0.0952 0.316 no dn no no no no d18:1-16:0-SM+blood L-Arginine+blood -0.527819549 0 0 serum_phospholipids serum_aminoacids 0.14 0.316 no no no no no no d18:1-20:0-SM+blood L-Arginine+blood -0.445112782 0 0 serum_phospholipids serum_aminoacids 0.933 0.316 no no no no no no DHA+blood L-Arginine+blood 0 0.598039216 0 serum_ARA serum_aminoacids 0.872 0.316 no no no no no no Dilated cardiomyopathy L-Arginine+blood 0 0 -0.422307692 kegg serum_aminoacids NA 0.316 no up up no no no DMG+blood L-Arginine+blood 0.448120301 0.549019608 0 serum_choline serum_aminoacids 0.909 0.316 no no no no no no EGFR tyrosine kinase inhibitor resistance L-Arginine+blood 0 0 0.423846154 kegg serum_aminoacids NA 0.316 no no no no no no Estrogen signaling pathway L-Arginine+blood -0.524561404 0 0 kegg serum_aminoacids NA 0.316 no no no no no no Glycine+blood L-Arginine+blood 0 0 0.442051282 serum_aminoacids serum_aminoacids 0.00408 0.316 dn no up no no no Glycolysis / Gluconeogenesis L-Arginine+blood -0.564912281 0 0 kegg serum_aminoacids NA 0.316 no no no no no no GPC+blood L-Arginine+blood 0 0.534313725 0 serum_choline serum_aminoacids 0.00427 0.316 no up up no no no HIF-1 signaling pathway L-Arginine+blood 0 0 0.5 kegg serum_aminoacids NA 0.316 no no no no no no Inflammatory bowel disease L-Arginine+blood 0.575438596 0 -0.434615385 kegg serum_aminoacids NA 0.316 no no no no no no Insulin signaling pathway L-Arginine+blood 0 0 0.423846154 kegg serum_aminoacids NA 0.316 no no no no no no Intestinal immune network for IgA production L-Arginine+blood 0 0 -0.563076923 kegg serum_aminoacids NA 0.316 no no no no no no Kaposi sarcoma-associated herpesvirus infection L-Arginine+blood 0.464912281 0 0 kegg serum_aminoacids NA 0.316 no no dn no no no L-2-Aminobutyric acid+blood L-Arginine+blood 0.553383459 0.602941176 0.407179487 yes serum_aminoacids serum_aminoacids 0.000328 0.316 up up no no no no Legionellosis L-Arginine+blood -0.468421053 0 0 kegg serum_aminoacids NA 0.316 no no no no no no mTOR signaling pathway L-Arginine+blood 0 0 0.404615385 kegg serum_aminoacids NA 0.316 no no no no no no Primary immunodeficiency L-Arginine+blood -0.636842105 0 0 kegg serum_aminoacids NA 0.316 no no no no no no Ribosome L-Arginine+blood 0 0 0.506923077 kegg serum_aminoacids NA 0.316 no no no no no no Signaling pathways regulating pluripotency of stem cells L-Arginine+blood 0 -0.564705882 0 kegg serum_aminoacids NA 0.316 no no no no no no Th1 and Th2 cell differentiation L-Arginine+blood 0.538596491 0 0 kegg serum_aminoacids NA 0.316 no no no no no no Th17 cell differentiation L-Arginine+blood 0.510526316 0 0 kegg serum_aminoacids NA 0.316 no no no no no no 14:0-LPC+blood L-Asparagine+blood 0 0 -0.426324786 serum_phospholipids serum_aminoacids 0.00689 0.784 up up no no no no 14:0/16:0-PC+blood L-Asparagine+blood -0.52481203 -0.644607843 0 serum_phospholipids serum_aminoacids 0.0358 0.784 no up no no no no 14:0/18:2-PC+blood L-Asparagine+blood -0.628571429 0 -0.405811966 serum_phospholipids serum_aminoacids 0.102 0.784 no up no no no no 14:0/20:4-PC+blood L-Asparagine+blood -0.631578947 0 0 serum_phospholipids serum_aminoacids 0.486 0.784 no no no no no no 14:1/18:2-PG+blood L-Asparagine+blood 0 0 -0.534358974 serum_phospholipids serum_aminoacids 0.00259 0.784 no up up no no no 16:0/16:0-PI+blood L-Asparagine+blood 0 0 -0.543931624 serum_phospholipids serum_aminoacids 0.358 0.784 no no no no no no 16:0/16:1-PI+blood L-Asparagine+blood 0 0 -0.645811966 serum_phospholipids serum_aminoacids 0.262 0.784 no no no no no no 16:0/18:0-PS+blood L-Asparagine+blood 0 -0.698529412 0 serum_phospholipids serum_aminoacids 0.377 0.784 no no no no no no 16:0/18:2-PI+blood L-Asparagine+blood 0 0 -0.612991453 serum_phospholipids serum_aminoacids 0.269 0.784 no no no no no no 16:0/20:4-PI+blood L-Asparagine+blood 0 0 -0.667692308 serum_phospholipids serum_aminoacids 0.558 0.784 no no no no no no 16:0/20:5-PC+blood L-Asparagine+blood 0 -0.659313725 0 serum_phospholipids serum_aminoacids 0.628 0.784 no no no no no no 16:0/22:0-PE+blood L-Asparagine+blood 0 0 0.549401709 serum_phospholipids serum_aminoacids 0.00839 0.784 dn no up no no no 16:0/22:6-PC+blood L-Asparagine+blood 0 0 0.441367521 serum_phospholipids serum_aminoacids 4.53E-05 0.784 no up up no no no 16:0/22:6-PE+blood L-Asparagine+blood 0 -0.504901961 0 serum_phospholipids serum_aminoacids 0.000934 0.784 up up no no no no 16:1-LPC+blood L-Asparagine+blood 0 0 -0.455042735 serum_phospholipids serum_aminoacids 0.0241 0.784 no up no no no no 16:1+blood L-Asparagine+blood 0 0 -0.402393162 yes serum_fattyacid serum_aminoacids 0.0186 0.784 no no dn no no no 18:0/18:0-PS+blood L-Asparagine+blood 0 -0.791666667 0 serum_phospholipids serum_aminoacids 0.00617 0.784 no up no no no no 18:0/18:1-PG+blood L-Asparagine+blood 0 0 -0.543931624 serum_phospholipids serum_aminoacids 0.000842 0.784 no up no no no no 18:0/18:2-PC+blood L-Asparagine+blood 0 0 0.438632479 serum_phospholipids serum_aminoacids 1.74E-06 0.784 no up up no no no 18:0/20:3-PC+blood L-Asparagine+blood -0.445112782 0 0 serum_phospholipids serum_aminoacids 0.0682 0.784 no up no no no no 18:0/20:5-PC+blood L-Asparagine+blood 0 0 0.410598291 serum_phospholipids serum_aminoacids 0.17 0.784 no no no no no no 18:0/22:6-PA+blood L-Asparagine+blood 0 -0.517156863 0 serum_phospholipids serum_aminoacids 0.22 0.784 no no no no no no 18:0/22:6-PE+blood L-Asparagine+blood 0 -0.534313725 0 serum_phospholipids serum_aminoacids 0.00022 0.784 up up no no no no 18:1/16:0-PC+blood L-Asparagine+blood 0 0 0.40991453 serum_phospholipids serum_aminoacids 2.43E-05 0.784 no up up no no no 18:1/16:0-PE+blood L-Asparagine+blood 0 0 -0.50017094 serum_phospholipids serum_aminoacids 0.000182 0.784 up up no no no no 18:1/18:0-PC+blood L-Asparagine+blood 0 0 0.419487179 serum_phospholipids serum_aminoacids 1.83E-06 0.784 no up up no no no 18:1/18:0-PE+blood L-Asparagine+blood 0 0 -0.442735043 serum_phospholipids serum_aminoacids 1.39E-06 0.784 up up no no no no 18:1/18:0-PS+blood L-Asparagine+blood 0 -0.632352941 0 serum_phospholipids serum_aminoacids 0.193 0.784 no no no no no no 18:1/18:1-PE+blood L-Asparagine+blood 0 0 -0.433846154 serum_phospholipids serum_aminoacids 1.03E-05 0.784 up up no no no no 18:2-LPA+blood L-Asparagine+blood 0 0.632352941 0 serum_phospholipids serum_aminoacids 0.00684 0.784 dn no up no no no 18:3/16:0-PE+blood L-Asparagine+blood 0 0 -0.481709402 serum_phospholipids serum_aminoacids 0.00149 0.784 up up no no no no 18:3n6+blood L-Asparagine+blood 0 0 -0.491965812 serum_fattyacid serum_aminoacids 0.0463 0.784 up no dn no no no 20:0/20:4-PE+blood L-Asparagine+blood 0 0 -0.431111111 serum_phospholipids serum_aminoacids 0.00128 0.784 up up no no no no 20:1-LPC+blood L-Asparagine+blood 0 0 0.453675214 serum_phospholipids serum_aminoacids 0.217 0.784 no no no no no no 20:2-LPE+blood L-Asparagine+blood -0.532330827 0 0 serum_phospholipids serum_aminoacids 0.177 0.784 no no no no no no 20:2/18:0-PC+blood L-Asparagine+blood -0.466165414 0 0 serum_phospholipids serum_aminoacids 0.0427 0.784 no up no no no no 20:2/18:1-PE+blood L-Asparagine+blood 0 0 -0.42974359 serum_phospholipids serum_aminoacids 0.00208 0.784 up up no no no no 20:4-LPA+blood L-Asparagine+blood 0 0.593137255 0 serum_phospholipids serum_aminoacids 0.398 0.784 no no no no no no 20:4/16:0-PE+blood L-Asparagine+blood 0 0 -0.474188034 serum_phospholipids serum_aminoacids 0.00529 0.784 no up up no no no 20:5n3+blood L-Asparagine+blood 0 -0.651960784 0 serum_fattyacid serum_aminoacids 0.988 0.784 no no no no no no 4-hydroxybenzoic acid+stool L-Asparagine+blood 0 0 0.47518797 stool_cometabolism serum_aminoacids 0.0536 0.784 no dn no no no no 8-HETE+blood L-Asparagine+blood 0 0.612745098 0 serum_ARA serum_aminoacids 0.741 0.784 no no no no no no 9-HODE+blood L-Asparagine+blood -0.446616541 0 0 serum_ARA serum_aminoacids 0.297 0.784 no no no no no no Adipocytokine signaling pathway L-Asparagine+blood 0 0.541176471 0 kegg serum_aminoacids NA 0.784 no no no no no no Alcoholism L-Asparagine+blood 0 0 -0.412307692 kegg serum_aminoacids NA 0.784 no no no no no no Apoptosis L-Asparagine+blood 0.461403509 0 0 kegg serum_aminoacids NA 0.784 no no no no no no Betaine+blood L-Asparagine+blood 0 0.529411765 0.437264957 serum_choline serum_aminoacids 0.857 0.784 no no no no no no Butyricimonas L-Asparagine+blood 0 -0.538411071 0 butyrate-producing Genus serum_aminoacids 0.17 0.784 no no no no no no cAMP signaling pathway L-Asparagine+blood 0 0.538235294 -0.401538462 yes kegg serum_aminoacids NA 0.784 no up up no no no capric acid C6+blood L-Asparagine+blood 0 0 0.445470085 serum_scfa serum_aminoacids 0.433 0.784 no no no no no no Cell cycle L-Asparagine+blood -0.489473684 -0.502941176 0 kegg serum_aminoacids NA 0.784 no no no no no no Choline+blood L-Asparagine+blood 0 0.68627451 0 serum_choline serum_aminoacids 0.0395 0.784 no up no no no no Cocaine addiction L-Asparagine+blood 0 0 -0.498461538 kegg serum_aminoacids NA 0.784 no no no no no no Colorectal cancer L-Asparagine+blood 0 -0.558823529 0 kegg serum_aminoacids NA 0.784 no no no no no no Cortisol synthesis and secretion L-Asparagine+blood 0 0 -0.493846154 kegg serum_aminoacids NA 0.784 no no up no no no Creatinine+blood L-Asparagine+blood 0.559398496 0.571078431 0.468717949 serum_choline serum_aminoacids 0.437 0.784 no no no no no no Cysteine+blood L-Asparagine+blood 0 0 0.408547009 yes serum_aminoacids serum_aminoacids 1.81E-07 0.784 dn up up no no no Cystine+blood L-Asparagine+blood 0.687218045 0.49754902 0 yes serum_aminoacids serum_aminoacids 0.00028 0.784 up up no no no no d18:1-14:0-SM+blood L-Asparagine+blood 0 -0.632352941 0 serum_phospholipids serum_aminoacids 0.94 0.784 no no no no no no d18:1-14:1-SM+blood L-Asparagine+blood -0.598496241 -0.526960784 -0.470769231 serum_phospholipids serum_aminoacids 0.0952 0.784 no dn no no no no d18:1-16:1-SM+blood L-Asparagine+blood 0 0 -0.488547009 serum_phospholipids serum_aminoacids 0.2 0.784 no no no no no no DL-methionine sulfoxide+blood L-Asparagine+blood 0 0.541666667 0 serum_aminoacids serum_aminoacids 0.302 0.784 no no no no no no Endocrine and other factor-regulated calcium reabsorption L-Asparagine+blood 0 0 -0.453846154 kegg serum_aminoacids NA 0.784 no no no no no no Epithelial cell signaling in Helicobacter pylori infection L-Asparagine+blood 0 0.547058824 0 kegg serum_aminoacids NA 0.784 no no no no no no Estrogen signaling pathway L-Asparagine+blood -0.510526316 0 0 kegg serum_aminoacids NA 0.784 no no no no no no Ethanolamine+blood L-Asparagine+blood 0.523308271 0.605392157 0 serum_aminoacids serum_aminoacids 0.122 0.784 up no no no no no Ferroptosis L-Asparagine+blood 0.538596491 0 0 kegg serum_aminoacids NA 0.784 no no no no no no Gap junction L-Asparagine+blood 0 0 -0.416153846 kegg serum_aminoacids NA 0.784 no no no no no no Glycine+blood L-Asparagine+blood 0 0.723039216 0.483760684 serum_aminoacids serum_aminoacids 0.00408 0.784 dn no up no no no GPC+blood L-Asparagine+blood 0 0.75245098 0 serum_choline serum_aminoacids 0.00427 0.784 no up up no no no HDCA+blood L-Asparagine+blood 0.457488141 0 0 serum_bileacids serum_aminoacids 0.483 0.784 no no no no no no heptanoic acid C7+blood L-Asparagine+blood 0.532330827 0 0 serum_mcfa serum_aminoacids 8.27E-11 0.784 dn dn no no no no Hypotaurine+blood L-Asparagine+blood 0 0.708333333 0 serum_aminoacids serum_aminoacids 0.933 0.784 no no no no no no Influenza A L-Asparagine+blood 0.501754386 0 0 kegg serum_aminoacids NA 0.784 no no no no no no Insulin secretion L-Asparagine+blood 0 0 -0.434615385 yes kegg serum_aminoacids NA 0.784 no up up no no no iso-DCA+blood L-Asparagine+blood 0 0.49754902 0 serum_bileacids serum_aminoacids 0.38 0.784 no no no no no no L-Alanine+blood L-Asparagine+blood 0.664661654 0 0 yes serum_aminoacids serum_aminoacids 0.00138 0.784 up up no no no no L-Arginine+blood L-Asparagine+blood 0 0 0.485128205 serum_aminoacids serum_aminoacids 0.316 0.784 no no no no no no L-Phenylalanine+stool L-Asparagine+blood 0 0 0.551879699 stool_cometabolism serum_aminoacids 0.398 0.784 no no no no no no L-Tyrosine+stool L-Asparagine+blood 0 0 0.616541353 stool_cometabolism serum_aminoacids 0.44 0.784 no no no no no no Long-term depression L-Asparagine+blood 0 0 -0.569230769 kegg serum_aminoacids NA 0.784 no no no no no no Longevity regulating pathway - multiple species L-Asparagine+blood -0.512280702 0 0 kegg serum_aminoacids NA 0.784 no no no no no no Morphine addiction L-Asparagine+blood 0 0 -0.405384615 kegg serum_aminoacids NA 0.784 no up up no no no Oocyte meiosis L-Asparagine+blood 0 -0.5 0 kegg serum_aminoacids NA 0.784 no no no no no no Pancreatic secretion L-Asparagine+blood 0 0 -0.402307692 kegg serum_aminoacids NA 0.784 no no no no no no Primary immunodeficiency L-Asparagine+blood -0.466666667 0 0 kegg serum_aminoacids NA 0.784 no no no no no no Progesterone-mediated oocyte maturation L-Asparagine+blood -0.470175439 0 0 kegg serum_aminoacids NA 0.784 no no no no no no Ras signaling pathway L-Asparagine+blood 0 -0.547058824 0 yes kegg serum_aminoacids NA 0.784 no up up no no no Regulation of lipolysis in adipocytes L-Asparagine+blood 0 0 -0.477692308 kegg serum_aminoacids NA 0.784 no no no no no no Relaxin signaling pathway L-Asparagine+blood 0 0 -0.425384615 kegg serum_aminoacids NA 0.784 no no no no no no Renin secretion L-Asparagine+blood 0 0 -0.401538462 kegg serum_aminoacids NA 0.784 no no no no no no RIG-I-like receptor signaling pathway L-Asparagine+blood 0 0 -0.413076923 kegg serum_aminoacids NA 0.784 no no no no no no Small cell lung cancer L-Asparagine+blood 0 0 -0.424615385 kegg serum_aminoacids NA 0.784 no no up no no no Spinocerebellar ataxia L-Asparagine+blood 0 -0.585294118 0 kegg serum_aminoacids NA 0.784 no no no no no no Transcriptional misregulation in cancer L-Asparagine+blood 0 0 -0.447692308 kegg serum_aminoacids NA 0.784 no no no no no no Vasopressin-regulated water reabsorption L-Asparagine+blood 0 0 -0.403076923 kegg serum_aminoacids NA 0.784 no no no no no no 13-HODE+blood L-Aspartic acid+blood 0 0.580882353 0 yes serum_ARA serum_aminoacids 0.32 0.0226 no no no up up no 14:0/18:2-PC+blood L-Aspartic acid+blood -0.460150376 0 0 yes serum_phospholipids serum_aminoacids 0.102 0.0226 no up no up up no 16:0/14:0-PC+blood L-Aspartic acid+blood 0 0.659313725 0.431794872 yes serum_phospholipids serum_aminoacids 0.0206 0.0226 no up up up up no 16:0/16:0-PC+blood L-Aspartic acid+blood 0 0.517156863 0 yes serum_phospholipids serum_aminoacids 0.00079 0.0226 no up up up up no 16:0/18:2-PC+blood L-Aspartic acid+blood 0 0.575980392 0 yes serum_phospholipids serum_aminoacids 3.24E-06 0.0226 no up up up up no 16:0/20:4-PC+blood L-Aspartic acid+blood 0.50075188 0.590686275 0 yes serum_phospholipids serum_aminoacids 0.0262 0.0226 no up no up up no 16:0/20:4-PI+blood L-Aspartic acid+blood 0 -0.585784314 0 yes serum_phospholipids serum_aminoacids 0.558 0.0226 no no no up up no 16:0/22:6-PE+blood L-Aspartic acid+blood 0 0 -0.414017094 yes serum_phospholipids serum_aminoacids 0.000934 0.0226 up up no up up no 18:0-LPC+blood L-Aspartic acid+blood -0.505263158 0 0 yes serum_phospholipids serum_aminoacids 0.554 0.0226 no no no up up no 18:0/16:0-PC+blood L-Aspartic acid+blood 0 0.482843137 0 yes serum_phospholipids serum_aminoacids 9.64E-07 0.0226 up up up up up no 18:0/18:0-PE+blood L-Aspartic acid+blood 0 -0.492647059 -0.541880342 yes serum_phospholipids serum_aminoacids 0.00896 0.0226 up up no up up no 18:0/18:1-PE+blood L-Aspartic acid+blood 0 0 -0.519316239 yes serum_phospholipids serum_aminoacids 0.00716 0.0226 up up no up up no 18:0/18:1-PG+blood L-Aspartic acid+blood 0 -0.585784314 0 yes serum_phospholipids serum_aminoacids 0.000842 0.0226 no up no up up no 18:0/20:3-PC+blood L-Aspartic acid+blood -0.52481203 0 0 yes serum_phospholipids serum_aminoacids 0.0682 0.0226 no up no up up no 18:0/22:6-PC+blood L-Aspartic acid+blood 0 0 0.55965812 yes serum_phospholipids serum_aminoacids 0.0775 0.0226 no no up up up no 18:0+blood L-Aspartic acid+blood 0 0 0.414700855 yes serum_fattyacid serum_aminoacids 0.344 0.0226 no no no up up no 18:1/16:0-PC+blood L-Aspartic acid+blood 0 0.615196078 0 yes serum_phospholipids serum_aminoacids 2.43E-05 0.0226 no up up up up no 18:1/16:0-PE+blood L-Aspartic acid+blood 0 0 -0.491282051 yes serum_phospholipids serum_aminoacids 0.000182 0.0226 up up no up up no 18:1/18:0-PE+blood L-Aspartic acid+blood 0 0 -0.565128205 yes serum_phospholipids serum_aminoacids 1.39E-06 0.0226 up up no up up no 18:1/18:1-PE+blood L-Aspartic acid+blood 0 0 -0.605470085 yes serum_phospholipids serum_aminoacids 1.03E-05 0.0226 up up no up up no 18:1/18:1-PG+blood L-Aspartic acid+blood 0 -0.495098039 0 yes serum_phospholipids serum_aminoacids 0.00352 0.0226 no up up up up no 18:1/18:2-PE+blood L-Aspartic acid+blood 0 0 -0.759316239 yes serum_phospholipids serum_aminoacids 0.000293 0.0226 up up no up up no 18:1/18:2-PG+blood L-Aspartic acid+blood 0 -0.495098039 0 yes serum_phospholipids serum_aminoacids 5.58E-07 0.0226 no up up up up no 18:1/20:4-PE+blood L-Aspartic acid+blood 0 0 -0.524102564 yes serum_phospholipids serum_aminoacids 0.0578 0.0226 up no no up up no 18:1/20:4-PI+blood L-Aspartic acid+blood 0 -0.492647059 0 yes serum_phospholipids serum_aminoacids 0.192 0.0226 no no no up up no 18:2/16:0-PC+blood L-Aspartic acid+blood 0 0.504901961 0 yes serum_phospholipids serum_aminoacids 8.67E-05 0.0226 no up up up up no 18:3/18:2-PC+blood L-Aspartic acid+blood -0.54887218 0 0 yes serum_phospholipids serum_aminoacids 0.0394 0.0226 no no up up up no 18:3n6+blood L-Aspartic acid+blood 0 -0.639705882 0 yes serum_fattyacid serum_aminoacids 0.0463 0.0226 up no dn up up no 20:0/20:4-PE+blood L-Aspartic acid+blood 0 0 -0.542564103 yes serum_phospholipids serum_aminoacids 0.00128 0.0226 up up no up up no 20:1/20:4-PC+blood L-Aspartic acid+blood 0 0 0.531623932 yes serum_phospholipids serum_aminoacids 0.0419 0.0226 no no up up up no 20:1/20:4-PE+blood L-Aspartic acid+blood 0 0 -0.40991453 yes serum_phospholipids serum_aminoacids 0.0042 0.0226 up up no up up no 20:2-LPC+blood L-Aspartic acid+blood 0 0.56372549 0 yes serum_phospholipids serum_aminoacids 0.119 0.0226 no no up up up no 20:2/18:0-PC+blood L-Aspartic acid+blood -0.511278195 0 0 yes serum_phospholipids serum_aminoacids 0.0427 0.0226 no up no up up no 20:2/18:1-PE+blood L-Aspartic acid+blood -0.448120301 0 -0.544615385 yes serum_phospholipids serum_aminoacids 0.00208 0.0226 up up no up up no 20:2/18:3-PE+blood L-Aspartic acid+blood 0 0 -0.504273504 yes serum_phospholipids serum_aminoacids 0.0391 0.0226 up up no up up no 20:3/16:0-PC+blood L-Aspartic acid+blood 0.503759398 0.612745098 0 yes serum_phospholipids serum_aminoacids 0.00405 0.0226 no up up up up no 20:3/18:0-PC+blood L-Aspartic acid+blood 0 0.615196078 0.416752137 yes serum_phospholipids serum_aminoacids 0.296 0.0226 no no no up up no 20:4/16:0-PE+blood L-Aspartic acid+blood -0.565413534 0 -0.418119658 yes serum_phospholipids serum_aminoacids 0.00529 0.0226 no up up up up no 20:4/18:0-PE+blood L-Aspartic acid+blood 0 0 -0.401025641 yes serum_phospholipids serum_aminoacids 0.000755 0.0226 up up no up up no 20:5/18:0-PC+blood L-Aspartic acid+blood 0 0.50245098 0 yes serum_phospholipids serum_aminoacids 3.97E-06 0.0226 no up up up up no 22:6-LPC+blood L-Aspartic acid+blood 0 0 0.512478632 yes serum_phospholipids serum_aminoacids 0.127 0.0226 no no up up up no 22:6n3+blood L-Aspartic acid+blood 0 0 0.483076923 yes serum_fattyacid serum_aminoacids 0.792 0.0226 no no no up up no 8-HETE+blood L-Aspartic acid+blood 0 0.647058824 0 yes serum_ARA serum_aminoacids 0.741 0.0226 no no no up up no Alistipes L-Aspartic acid+blood 0 0 -0.406520402 yes Genus serum_aminoacids 0.0114 0.0226 no up no up up no AMPK signaling pathway L-Aspartic acid+blood 0.473684211 0 0 yes kegg serum_aminoacids NA 0.0226 no no no up up no Axon guidance L-Aspartic acid+blood -0.61754386 0 -0.443846154 yes kegg serum_aminoacids NA 0.0226 no up up up up no Betaine+blood L-Aspartic acid+blood 0 0 0.409230769 yes serum_choline serum_aminoacids 0.857 0.0226 no no no up up no Cardiac muscle contraction L-Aspartic acid+blood -0.456140351 0 0 yes kegg serum_aminoacids NA 0.0226 no no up up up no Cystine+blood L-Aspartic acid+blood 0.47518797 0 0 yes yes serum_aminoacids serum_aminoacids 0.00028 0.0226 up up no up up no Diabetic cardiomyopathy L-Aspartic acid+blood -0.485964912 0 0 yes kegg serum_aminoacids NA 0.0226 no no no up up no DPA+blood L-Aspartic acid+blood 0 0 0.403076923 yes serum_ARA serum_aminoacids 0.519 0.0226 no no no up up no EPA+blood L-Aspartic acid+blood 0 0 0.425641026 yes serum_ARA serum_aminoacids 0.212 0.0226 no no no up up no Estrogen signaling pathway L-Aspartic acid+blood 0 0 -0.546153846 yes kegg serum_aminoacids NA 0.0226 no no no up up no Ethanolamine+blood L-Aspartic acid+blood 0.481203008 0 0 yes serum_aminoacids serum_aminoacids 0.122 0.0226 up no no up up no Ferroptosis L-Aspartic acid+blood 0.466666667 0 0 yes kegg serum_aminoacids NA 0.0226 no no no up up no Glioma L-Aspartic acid+blood -0.524561404 -0.688235294 -0.415384615 yes kegg serum_aminoacids NA 0.0226 no no no up up no Glycine+blood L-Aspartic acid+blood 0.760902256 0 0.43042735 yes serum_aminoacids serum_aminoacids 0.00408 0.0226 dn no up up up no GPC+blood L-Aspartic acid+blood 0 0.644607843 0 yes serum_choline serum_aminoacids 0.00427 0.0226 no up up up up no HDCA+blood L-Aspartic acid+blood 0.487794926 0 0 yes serum_bileacids serum_aminoacids 0.483 0.0226 no no no up up no Hypotaurine+blood L-Aspartic acid+blood 0 0.578431373 0 yes serum_aminoacids serum_aminoacids 0.933 0.0226 no no no up up no Intestinal immune network for IgA production L-Aspartic acid+blood 0 0 -0.445384615 yes kegg serum_aminoacids NA 0.0226 no no no up up no L-Arginine+blood L-Aspartic acid+blood 0 0.534313725 0.473504274 yes serum_aminoacids serum_aminoacids 0.316 0.0226 no no no up up no L-Asparagine+blood L-Aspartic acid+blood 0.452631579 0 0 yes serum_aminoacids serum_aminoacids 0.784 0.0226 no no no up up no Long-term potentiation L-Aspartic acid+blood -0.540350877 0 0 yes kegg serum_aminoacids NA 0.0226 no no up up up no Measles L-Aspartic acid+blood 0 0 0.44 yes kegg serum_aminoacids NA 0.0226 no no no up up no Pancreatic cancer L-Aspartic acid+blood -0.459649123 0 -0.583846154 yes kegg serum_aminoacids NA 0.0226 no no no up up no Phosphatidylinositol signaling system L-Aspartic acid+blood 0 -0.544117647 0 yes kegg serum_aminoacids NA 0.0226 no no no up up no Porphyrin and chlorophyll metabolism L-Aspartic acid+blood 0.459649123 0 0 yes kegg serum_aminoacids NA 0.0226 no no no up up no Purine metabolism L-Aspartic acid+blood 0.510526316 0 0 yes kegg serum_aminoacids NA 0.0226 no no no up up no TGF-beta signaling pathway L-Aspartic acid+blood -0.498245614 0 0 yes kegg serum_aminoacids NA 0.0226 no no no up up no 11-HETE+blood L-Citrulline+blood 0.468449746 0 0 serum_ARA serum_aminoacids 0.464 0.534 no no no no no no 12-HEPE+blood L-Citrulline+blood 0.459595975 -0.517029533 0 serum_ARA serum_aminoacids 0.312 0.534 no no no no no no 13-HODE+blood L-Citrulline+blood 0 0 0.429059829 serum_ARA serum_aminoacids 0.32 0.534 no no no no no no 14:0+blood L-Citrulline+blood -0.52481203 0 0 yes serum_fattyacid serum_aminoacids 0.00572 0.534 up no dn no no no 16:0-LPE+blood L-Citrulline+blood 0 0 -0.483076923 serum_phospholipids serum_aminoacids 0.0711 0.534 up up no no no no 16:0/16:1-PC+blood L-Citrulline+blood 0 0 -0.40991453 serum_phospholipids serum_aminoacids 0.00283 0.534 up up no no no no 16:0/16:1-PI+blood L-Citrulline+blood 0 0 -0.416068376 serum_phospholipids serum_aminoacids 0.262 0.534 no no no no no no 16:0/18:0-PS+blood L-Citrulline+blood -0.49924812 -0.575980392 0 serum_phospholipids serum_aminoacids 0.377 0.534 no no no no no no 16:0/18:1-PE+blood L-Citrulline+blood 0 0 -0.55008547 serum_phospholipids serum_aminoacids 0.000107 0.534 up up no no no no 16:0/18:2-PI+blood L-Citrulline+blood 0 0 -0.432478632 serum_phospholipids serum_aminoacids 0.269 0.534 no no no no no no 16:0/20:4-PE+blood L-Citrulline+blood 0 0 -0.408547009 serum_phospholipids serum_aminoacids 0.00139 0.534 up up no no no no 16:0/20:4-PI+blood L-Citrulline+blood 0 0 -0.565128205 serum_phospholipids serum_aminoacids 0.558 0.534 no no no no no no 16:0/20:5-PC+blood L-Citrulline+blood 0 -0.524509804 0 serum_phospholipids serum_aminoacids 0.628 0.534 no no no no no no 16:0/22:6-PE+blood L-Citrulline+blood 0 0 -0.446153846 serum_phospholipids serum_aminoacids 0.000934 0.534 up up no no no no 18:0-LPC+blood L-Citrulline+blood 0 0 0.461880342 serum_phospholipids serum_aminoacids 0.554 0.534 no no no no no no 18:0/18:0-PS+blood L-Citrulline+blood 0 -0.549019608 0 serum_phospholipids serum_aminoacids 0.00617 0.534 no up no no no no 18:1/16:1-PE+blood L-Citrulline+blood 0 0 -0.541880342 serum_phospholipids serum_aminoacids 0.000184 0.534 up up no no no no 18:1/18:0-PE+blood L-Citrulline+blood 0 0 -0.460512821 serum_phospholipids serum_aminoacids 1.39E-06 0.534 up up no no no no 18:1/18:1-PE+blood L-Citrulline+blood 0 0 -0.42017094 serum_phospholipids serum_aminoacids 1.03E-05 0.534 up up no no no no 18:3/16:0-PE+blood L-Citrulline+blood 0 0 -0.428376068 serum_phospholipids serum_aminoacids 0.00149 0.534 up up no no no no 20:0-LPC+blood L-Citrulline+blood 0 0 0.436581197 serum_phospholipids serum_aminoacids 0.199 0.534 no no no no no no 20:1+blood L-Citrulline+blood 0 0 0.435213675 yes serum_fattyacid serum_aminoacids 2.56E-05 0.534 dn dn dn no no no 20:2/18:1-PE+blood L-Citrulline+blood 0 0 -0.476239316 serum_phospholipids serum_aminoacids 0.00208 0.534 up up no no no no 20:3n6+blood L-Citrulline+blood 0 0 -0.473504274 serum_fattyacid serum_aminoacids 0.0884 0.534 up no no no no no 24:0+blood L-Citrulline+blood -0.50075188 0 0 serum_fattyacid serum_aminoacids 0.034 0.534 dn no up no no no "9,10-EPOME+blood" L-Citrulline+blood 0 0 0.422363627 serum_ARA serum_aminoacids 0.801 0.534 no no no no no no ACA+stool L-Citrulline+blood 0 0 -0.545676063 stool_bileacids serum_aminoacids 0.417 0.534 no no no no no no Adherens junction L-Citrulline+blood 0 -0.5 0 kegg serum_aminoacids NA 0.534 no no no no no no Adipocytokine signaling pathway L-Citrulline+blood 0.633333333 0.644117647 0 kegg serum_aminoacids NA 0.534 no no no no no no Allograft rejection L-Citrulline+blood 0 0 -0.474615385 kegg serum_aminoacids NA 0.534 no no no no no no AMPK signaling pathway L-Citrulline+blood 0 0.511764706 0 kegg serum_aminoacids NA 0.534 no no no no no no Arrhythmogenic right ventricular cardiomyopathy L-Citrulline+blood -0.524561404 -0.5 0 kegg serum_aminoacids NA 0.534 no up up no no no Asthma L-Citrulline+blood 0 -0.652941176 0 kegg serum_aminoacids NA 0.534 no no no no no no Autoimmune thyroid disease L-Citrulline+blood 0 0 -0.474615385 kegg serum_aminoacids NA 0.534 no no no no no no Autophagy - animal L-Citrulline+blood 0.605263158 0 0 kegg serum_aminoacids NA 0.534 no no no no no no B cell receptor signaling pathway L-Citrulline+blood 0.550877193 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Bacterial invasion of epithelial cells L-Citrulline+blood -0.470175439 -0.558823529 0 kegg serum_aminoacids NA 0.534 no no no no no no Betaine+blood L-Citrulline+blood 0 0 0.429059829 serum_choline serum_aminoacids 0.857 0.534 no no no no no no Butyric acid+stool L-Citrulline+blood 0 0.609090909 0 yes stool_scfa serum_aminoacids 0.102 0.534 dn no no no no no C-type lectin receptor signaling pathway L-Citrulline+blood 0.621052632 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Carbon metabolism L-Citrulline+blood -0.561403509 -0.520588235 0 kegg serum_aminoacids NA 0.534 no no no no no no Cell adhesion molecules L-Citrulline+blood 0 0 -0.578461538 kegg serum_aminoacids NA 0.534 no no no no no no Choline+blood L-Citrulline+blood 0.473684211 0 0 serum_choline serum_aminoacids 0.0395 0.534 no up no no no no Chronic myeloid leukemia L-Citrulline+blood 0.564912281 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Circadian entrainment L-Citrulline+blood -0.545614035 0 0 kegg serum_aminoacids NA 0.534 no up up no no no Clostridium L-Citrulline+blood 0 -0.581585543 0 Genus serum_aminoacids 0.925 0.534 no no no no no no Creatinine+blood L-Citrulline+blood 0.553383459 0 0 serum_choline serum_aminoacids 0.437 0.534 no no no no no no d18:1-14:1-SM+blood L-Citrulline+blood -0.508270677 0 0 serum_phospholipids serum_aminoacids 0.0952 0.534 no dn no no no no d18:1-20:0-SM+blood L-Citrulline+blood -0.55037594 0 0 serum_phospholipids serum_aminoacids 0.933 0.534 no no no no no no DHA+blood L-Citrulline+blood -0.455639098 0 0 serum_ARA serum_aminoacids 0.872 0.534 no no no no no no Dilated cardiomyopathy L-Citrulline+blood -0.592982456 0 0 kegg serum_aminoacids NA 0.534 no up up no no no DMG+blood L-Citrulline+blood 0.494736842 0 0.447521368 serum_choline serum_aminoacids 0.909 0.534 no no no no no no Estrogen signaling pathway L-Citrulline+blood -0.710526316 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Ferroptosis L-Citrulline+blood 0 0 -0.433076923 kegg serum_aminoacids NA 0.534 no no no no no no Fluid shear stress and atherosclerosis L-Citrulline+blood 0 -0.529411765 0 kegg serum_aminoacids NA 0.534 no no no no no no Focal adhesion L-Citrulline+blood -0.664912281 -0.5 0 kegg serum_aminoacids NA 0.534 no up up no no no Gap junction L-Citrulline+blood -0.503508772 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Gastric acid secretion L-Citrulline+blood -0.51754386 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Glycine+blood L-Citrulline+blood 0 0.62254902 0 serum_aminoacids serum_aminoacids 0.00408 0.534 dn no up no no no Glycolysis / Gluconeogenesis L-Citrulline+blood -0.650877193 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Graft-versus-host disease L-Citrulline+blood 0 0 -0.480769231 kegg serum_aminoacids NA 0.534 no no no no no no HDCA+stool L-Citrulline+blood 0 0.7 0 stool_bileacids serum_aminoacids 0.176 0.534 no no no no no no Hematopoietic cell lineage L-Citrulline+blood 0 -0.535294118 0 kegg serum_aminoacids NA 0.534 no no no no no no Hepatitis B L-Citrulline+blood 0.515789474 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Hepatocellular carcinoma L-Citrulline+blood 0 -0.520588235 0 kegg serum_aminoacids NA 0.534 no no no no no no Hippo signaling pathway L-Citrulline+blood -0.550877193 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Human papillomavirus infection L-Citrulline+blood 0 0 -0.446923077 kegg serum_aminoacids NA 0.534 no no no no no no Hypertrophic cardiomyopathy L-Citrulline+blood -0.533333333 -0.541176471 0 kegg serum_aminoacids NA 0.534 no up up no no no Hypotaurine+blood L-Citrulline+blood 0 0.566176471 0.490598291 serum_aminoacids serum_aminoacids 0.933 0.534 no no no no no no Inflammatory bowel disease L-Citrulline+blood 0.494736842 -0.670588235 0 kegg serum_aminoacids NA 0.534 no no no no no no Insulin resistance L-Citrulline+blood 0.58245614 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Intestinal immune network for IgA production L-Citrulline+blood 0 -0.579411765 0 kegg serum_aminoacids NA 0.534 no no no no no no iso-DCA+blood L-Citrulline+blood 0 0.487745098 0 serum_bileacids serum_aminoacids 0.38 0.534 no no no no no no Kaposi sarcoma-associated herpesvirus infection L-Citrulline+blood 0 0 -0.454615385 kegg serum_aminoacids NA 0.534 no no dn no no no L-2-Aminobutyric acid+blood L-Citrulline+blood 0 0 0.485811966 yes serum_aminoacids serum_aminoacids 0.000328 0.534 up up no no no no L-Arginine+blood L-Citrulline+blood 0.727819549 0 0.546666667 serum_aminoacids serum_aminoacids 0.316 0.534 no no no no no no L-Asparagine+blood L-Citrulline+blood 0.446616541 0.578431373 0.491282051 serum_aminoacids serum_aminoacids 0.784 0.534 no no no no no no Leukocyte transendothelial migration L-Citrulline+blood -0.464912281 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Longevity regulating pathway L-Citrulline+blood 0 0.758823529 0 kegg serum_aminoacids NA 0.534 no no no no no no Longevity regulating pathway - multiple species L-Citrulline+blood -0.459649123 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Methanobrevibacter L-Citrulline+blood 0 0 0.44849889 Genus serum_aminoacids 0.629 0.534 no no no no no no mRNA surveillance pathway L-Citrulline+blood 0.464912281 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Oxytocin signaling pathway L-Citrulline+blood -0.561403509 0 0 kegg serum_aminoacids NA 0.534 no no no no no no p53 signaling pathway L-Citrulline+blood 0.524561404 0.532352941 0 kegg serum_aminoacids NA 0.534 no no no no no no Pathways in cancer L-Citrulline+blood 0 0.538235294 0 kegg serum_aminoacids NA 0.534 no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer L-Citrulline+blood 0.585964912 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Phagosome L-Citrulline+blood 0 0 -0.435384615 kegg serum_aminoacids NA 0.534 no no no no no no Phosphatidylinositol signaling system L-Citrulline+blood 0 0 0.513846154 kegg serum_aminoacids NA 0.534 no no no no no no Platelet activation L-Citrulline+blood -0.622807018 -0.544117647 0 kegg serum_aminoacids NA 0.534 no no no no no no Primary immunodeficiency L-Citrulline+blood -0.577192982 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Progesterone-mediated oocyte maturation L-Citrulline+blood 0 0 0.523076923 kegg serum_aminoacids NA 0.534 no no no no no no Prostate cancer L-Citrulline+blood 0.515789474 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Purine metabolism L-Citrulline+blood 0 0.532352941 0 kegg serum_aminoacids NA 0.534 no no no no no no Rap1 signaling pathway L-Citrulline+blood -0.512280702 -0.505882353 0 kegg serum_aminoacids NA 0.534 no no no no no no Ras signaling pathway L-Citrulline+blood 0 0 0.447692308 yes kegg serum_aminoacids NA 0.534 no up up no no no Regulation of actin cytoskeleton L-Citrulline+blood -0.612280702 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Renin secretion L-Citrulline+blood -0.552631579 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Ribosome biogenesis in eukaryotes L-Citrulline+blood 0 0 0.463076923 kegg serum_aminoacids NA 0.534 no no no no no no RIG-I-like receptor signaling pathway L-Citrulline+blood 0.568421053 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Small cell lung cancer L-Citrulline+blood 0.536842105 0 0 kegg serum_aminoacids NA 0.534 no no up no no no Spinocerebellar ataxia L-Citrulline+blood 0 0 0.461538462 kegg serum_aminoacids NA 0.534 no no no no no no Th1 and Th2 cell differentiation L-Citrulline+blood 0.629824561 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Th17 cell differentiation L-Citrulline+blood 0.678947368 0 0 kegg serum_aminoacids NA 0.534 no no no no no no TNF signaling pathway L-Citrulline+blood 0.550877193 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Transcriptional misregulation in cancer L-Citrulline+blood 0.492982456 0 0 kegg serum_aminoacids NA 0.534 no no no no no no Type I diabetes mellitus L-Citrulline+blood 0 0 -0.476923077 kegg serum_aminoacids NA 0.534 no no no no no no Viral carcinogenesis L-Citrulline+blood 0 0 -0.432307692 kegg serum_aminoacids NA 0.534 no no no no no no Viral myocarditis L-Citrulline+blood 0 0 -0.513076923 kegg serum_aminoacids NA 0.534 no no no no no no 13-HODE+blood L-Glutamic acid+blood 0 0.49754902 0 yes serum_ARA serum_aminoacids 0.32 6.20E-05 no no no up up no 16:0/14:0-PC+blood L-Glutamic acid+blood 0 0.514705882 0 yes serum_phospholipids serum_aminoacids 0.0206 6.20E-05 no up up up up no 16:0/18:2-PC+blood L-Glutamic acid+blood 0 0.580882353 0 yes serum_phospholipids serum_aminoacids 3.24E-06 6.20E-05 no up up up up no 16:0/22:6-PE+blood L-Glutamic acid+blood 0 0 -0.434529915 yes serum_phospholipids serum_aminoacids 0.000934 6.20E-05 up up no up up no 18:0+blood L-Glutamic acid+blood 0 0 0.426324786 yes serum_fattyacid serum_aminoacids 0.344 6.20E-05 no no no up up no 18:1/16:0-PC+blood L-Glutamic acid+blood 0 0.578431373 0 yes serum_phospholipids serum_aminoacids 2.43E-05 6.20E-05 no up up up up no 18:1/18:0-PE+blood L-Glutamic acid+blood 0 0 -0.418803419 yes serum_phospholipids serum_aminoacids 1.39E-06 6.20E-05 up up no up up no 18:1/18:1-PE+blood L-Glutamic acid+blood 0 0 -0.43042735 yes serum_phospholipids serum_aminoacids 1.03E-05 6.20E-05 up up no up up no 18:1/18:2-PE+blood L-Glutamic acid+blood 0 0 -0.535042735 yes serum_phospholipids serum_aminoacids 0.000293 6.20E-05 up up no up up no 18:1/20:4-PE+blood L-Glutamic acid+blood 0 -0.487745098 0 yes serum_phospholipids serum_aminoacids 0.0578 6.20E-05 up no no up up no 18:2/16:0-PC+blood L-Glutamic acid+blood 0 0.573529412 0 yes serum_phospholipids serum_aminoacids 8.67E-05 6.20E-05 no up up up up no 18:3/18:2-PC+blood L-Glutamic acid+blood -0.563909774 0 0 yes serum_phospholipids serum_aminoacids 0.0394 6.20E-05 no no up up up no 20:0-LPC+blood L-Glutamic acid+blood 0 -0.514705882 0 yes serum_phospholipids serum_aminoacids 0.199 6.20E-05 no no no up up no 20:0+blood L-Glutamic acid+blood 0 -0.514705882 0 yes yes serum_fattyacid serum_aminoacids 0.000278 6.20E-05 dn no up up up no 20:2/18:1-PE+blood L-Glutamic acid+blood 0 0 -0.415384615 yes serum_phospholipids serum_aminoacids 0.00208 6.20E-05 up up no up up no 20:2/18:3-PE+blood L-Glutamic acid+blood 0 0 -0.44 yes serum_phospholipids serum_aminoacids 0.0391 6.20E-05 up up no up up no 20:4-LPC+blood L-Glutamic acid+blood 0.6 0 0 yes serum_phospholipids serum_aminoacids 0.949 6.20E-05 no no no up up no 5-HETE+blood L-Glutamic acid+blood 0 0.482269873 0 yes serum_ARA serum_aminoacids 0.697 6.20E-05 no no no up up no Adherens junction L-Glutamic acid+blood 0 0 -0.401538462 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Alistipes L-Glutamic acid+blood 0 -0.683016683 0 yes Genus serum_aminoacids 0.0114 6.20E-05 no up no up up no Amoebiasis L-Glutamic acid+blood 0 0 -0.460769231 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no AMPK signaling pathway L-Glutamic acid+blood 0 -0.505882353 0 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Antigen processing and presentation L-Glutamic acid+blood 0 0 -0.485384615 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Axon guidance L-Glutamic acid+blood -0.457894737 0 0 yes kegg serum_aminoacids NA 6.20E-05 no up up up up no Bacterial invasion of epithelial cells L-Glutamic acid+blood 0 0 -0.43 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Betaine+blood L-Glutamic acid+blood 0 0.634803922 0 yes serum_choline serum_aminoacids 0.857 6.20E-05 no no no up up no Blautia L-Glutamic acid+blood 0 0.571078431 0 acetate-producing yes Genus serum_aminoacids 1.36E-05 6.20E-05 up dn dn up up no Cell adhesion molecules L-Glutamic acid+blood 0 0 -0.444615385 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Cell cycle L-Glutamic acid+blood -0.561403509 0 0 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Chemical carcinogenesis - receptor activation L-Glutamic acid+blood 0 -0.558823529 0 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Choline+blood L-Glutamic acid+blood 0 0.696078431 0 yes serum_choline serum_aminoacids 0.0395 6.20E-05 no up no up up no Cholinergic synapse L-Glutamic acid+blood 0 -0.564705882 0 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Circadian entrainment L-Glutamic acid+blood 0 0 -0.412307692 yes kegg serum_aminoacids NA 6.20E-05 no up up up up no Colorectal cancer L-Glutamic acid+blood 0 -0.629411765 0 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Creatinine+blood L-Glutamic acid+blood 0.520300752 0.620098039 0 yes serum_choline serum_aminoacids 0.437 6.20E-05 no no no up up no Cystine+blood L-Glutamic acid+blood 0.520300752 0.590686275 0 yes yes serum_aminoacids serum_aminoacids 0.00028 6.20E-05 up up no up up no d18:1-14:0-SM+blood L-Glutamic acid+blood 0 -0.485294118 0 yes serum_phospholipids serum_aminoacids 0.94 6.20E-05 no no no up up no d18:1-14:1-SM+blood L-Glutamic acid+blood -0.526315789 -0.669117647 0 yes serum_phospholipids serum_aminoacids 0.0952 6.20E-05 no dn no up up no d18:1-16:1-SM+blood L-Glutamic acid+blood 0 -0.514705882 0 yes serum_phospholipids serum_aminoacids 0.2 6.20E-05 no no no up up no d18:1-22:1-SM+blood L-Glutamic acid+blood 0 -0.509803922 0 yes serum_phospholipids serum_aminoacids 0.222 6.20E-05 no no no up up no DHA+blood L-Glutamic acid+blood 0 0.509803922 0 yes serum_ARA serum_aminoacids 0.872 6.20E-05 no no no up up no Dilated cardiomyopathy L-Glutamic acid+blood 0 0 -0.564615385 yes kegg serum_aminoacids NA 6.20E-05 no up up up up no DL-methionine sulfoxide+blood L-Glutamic acid+blood 0 0.534313725 0 yes serum_aminoacids serum_aminoacids 0.302 6.20E-05 no no no up up no DMG+blood L-Glutamic acid+blood 0 0.544117647 0 yes serum_choline serum_aminoacids 0.909 6.20E-05 no no no up up no Dorea L-Glutamic acid+blood 0 0.49754902 0 yes Genus serum_aminoacids 0.00362 6.20E-05 up no dn up up no Estrogen signaling pathway L-Glutamic acid+blood 0 0 -0.577692308 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Ethanolamine+blood L-Glutamic acid+blood 0.568421053 0 0 yes serum_aminoacids serum_aminoacids 0.122 6.20E-05 up no no up up no Focal adhesion L-Glutamic acid+blood 0 0 -0.468461538 yes kegg serum_aminoacids NA 6.20E-05 no up up up up no Gap junction L-Glutamic acid+blood 0 0 -0.443076923 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Gastric acid secretion L-Glutamic acid+blood 0 0 -0.487692308 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Gastric cancer L-Glutamic acid+blood 0 -0.611764706 0 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no GPC+blood L-Glutamic acid+blood 0 0.634803922 0 yes serum_choline serum_aminoacids 0.00427 6.20E-05 no up up up up no Human T-cell leukemia virus 1 infection L-Glutamic acid+blood 0 0 -0.429230769 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Influenza A L-Glutamic acid+blood 0.521052632 0.576470588 0 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Insulin resistance L-Glutamic acid+blood 0 0 0.544615385 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no L-2-Aminobutyric acid+blood L-Glutamic acid+blood 0 0 0.474188034 yes yes serum_aminoacids serum_aminoacids 0.000328 6.20E-05 up up no up up no L-Alanine+blood L-Glutamic acid+blood 0.581954887 0 0.50974359 yes yes serum_aminoacids serum_aminoacids 0.00138 6.20E-05 up up no up up no L-Arginine+blood L-Glutamic acid+blood 0 0.566176471 0 yes serum_aminoacids serum_aminoacids 0.316 6.20E-05 no no no up up no L-Asparagine+blood L-Glutamic acid+blood 0.472180451 0.539215686 0 yes serum_aminoacids serum_aminoacids 0.784 6.20E-05 no no no up up no L-Aspartic acid+blood L-Glutamic acid+blood 0 0.600490196 0.647179487 yes yes serum_aminoacids serum_aminoacids 0.0226 6.20E-05 up up no up up no L-Citrulline+blood L-Glutamic acid+blood 0 0 0.416752137 yes serum_aminoacids serum_aminoacids 0.534 6.20E-05 no no no up up no Leukocyte transendothelial migration L-Glutamic acid+blood 0 0 -0.424615385 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Oocyte meiosis L-Glutamic acid+blood -0.456140351 0 0 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Oxytocin signaling pathway L-Glutamic acid+blood 0 0 -0.533846154 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Phosphatidylinositol signaling system L-Glutamic acid+blood 0 -0.502941176 0 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Phospholipase D signaling pathway L-Glutamic acid+blood 0.49122807 0 0 yes kegg serum_aminoacids NA 6.20E-05 no up up up up no Platelet activation L-Glutamic acid+blood 0 0 -0.467692308 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Platinum drug resistance L-Glutamic acid+blood 0 -0.547058824 0 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Prion disease L-Glutamic acid+blood 0 0 -0.42 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Regulation of actin cytoskeleton L-Glutamic acid+blood 0 0 -0.467692308 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Renin secretion L-Glutamic acid+blood 0 0 -0.401538462 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Rheumatoid arthritis L-Glutamic acid+blood 0 0 -0.426153846 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Salivary secretion L-Glutamic acid+blood 0 0 -0.42 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Salmonella infection L-Glutamic acid+blood 0 0.564705882 0 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Serotonergic synapse L-Glutamic acid+blood 0 0 -0.503846154 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Signaling pathways regulating pluripotency of stem cells L-Glutamic acid+blood 0 -0.620588235 0 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Systemic lupus erythematosus L-Glutamic acid+blood 0 0 -0.410769231 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no TGF-beta signaling pathway L-Glutamic acid+blood -0.473684211 0 0 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Tight junction L-Glutamic acid+blood 0 0 -0.447692308 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no Yersinia infection L-Glutamic acid+blood 0 0.605882353 0 yes kegg serum_aminoacids NA 6.20E-05 no no no up up no 14:0-LPC+blood L-Glutamine+blood 0 0 -0.608888889 serum_phospholipids serum_aminoacids 0.00689 0.639 up up no no no no 14:0/16:0-PC+blood L-Glutamine+blood 0 0 -0.431794872 serum_phospholipids serum_aminoacids 0.0358 0.639 no up no no no no 14:0/18:0-PC+blood L-Glutamine+blood 0 0 -0.461196581 serum_phospholipids serum_aminoacids 0.00289 0.639 up up no no no no 14:0/18:2-PC+blood L-Glutamine+blood -0.481203008 0 -0.634871795 serum_phospholipids serum_aminoacids 0.102 0.639 no up no no no no 14:0/20:4-PC+blood L-Glutamine+blood 0 0 -0.541880342 serum_phospholipids serum_aminoacids 0.486 0.639 no no no no no no 14:0+blood L-Glutamine+blood -0.488721805 0 -0.486495726 yes serum_fattyacid serum_aminoacids 0.00572 0.639 up no dn no no no 14:1/18:2-PG+blood L-Glutamine+blood 0 0 -0.648547009 serum_phospholipids serum_aminoacids 0.00259 0.639 no up up no no no 16:0/14:0-PC+blood L-Glutamine+blood 0 0 0.483760684 serum_phospholipids serum_aminoacids 0.0206 0.639 no up up no no no 16:0/16:0-PI+blood L-Glutamine+blood -0.454135338 0 -0.55965812 serum_phospholipids serum_aminoacids 0.358 0.639 no no no no no no 16:0/16:1-PC+blood L-Glutamine+blood 0 0 -0.493333333 serum_phospholipids serum_aminoacids 0.00283 0.639 up up no no no no 16:0/16:1-PI+blood L-Glutamine+blood 0 0 -0.55965812 serum_phospholipids serum_aminoacids 0.262 0.639 no no no no no no 16:0/18:0-PS+blood L-Glutamine+blood -0.452631579 -0.514705882 0 serum_phospholipids serum_aminoacids 0.377 0.639 no no no no no no 16:0/18:2-PC+blood L-Glutamine+blood 0 0 0.56991453 serum_phospholipids serum_aminoacids 3.24E-06 0.639 no up up no no no 16:0/18:2-PI+blood L-Glutamine+blood -0.482706767 0 -0.502905983 serum_phospholipids serum_aminoacids 0.269 0.639 no no no no no no 16:0/20:4-PC+blood L-Glutamine+blood 0.493233083 0 0 serum_phospholipids serum_aminoacids 0.0262 0.639 no up no no no no 16:0/20:4-PI+blood L-Glutamine+blood -0.490225564 0 -0.532991453 serum_phospholipids serum_aminoacids 0.558 0.639 no no no no no no 16:0/22:0-PE+blood L-Glutamine+blood 0 0 0.511794872 serum_phospholipids serum_aminoacids 0.00839 0.639 dn no up no no no 16:0/22:6-PC+blood L-Glutamine+blood 0 0 0.630769231 serum_phospholipids serum_aminoacids 4.53E-05 0.639 no up up no no no 16:0/22:6-PE+blood L-Glutamine+blood 0 -0.551470588 0 serum_phospholipids serum_aminoacids 0.000934 0.639 up up no no no no 16:0+blood L-Glutamine+blood 0 0 -0.404444444 yes serum_fattyacid serum_aminoacids 0.00876 0.639 up no no no no no 16:1-LPC+blood L-Glutamine+blood 0 0 -0.441367521 serum_phospholipids serum_aminoacids 0.0241 0.639 no up no no no no 16:1/16:0-PC+blood L-Glutamine+blood 0 0 0.537094017 serum_phospholipids serum_aminoacids 0.0215 0.639 no up up no no no 18:0-LPC+blood L-Glutamine+blood -0.532330827 0 0 serum_phospholipids serum_aminoacids 0.554 0.639 no no no no no no 18:0-LPE+blood L-Glutamine+blood -0.482706767 0 0 serum_phospholipids serum_aminoacids 0.491 0.639 no no no no no no 18:0/18:0-PE+blood L-Glutamine+blood 0 0 -0.457094017 serum_phospholipids serum_aminoacids 0.00896 0.639 up up no no no no 18:0/18:0-PS+blood L-Glutamine+blood 0 -0.595588235 0 serum_phospholipids serum_aminoacids 0.00617 0.639 no up no no no no 18:0/18:1-PE+blood L-Glutamine+blood 0 0 -0.446153846 serum_phospholipids serum_aminoacids 0.00716 0.639 up up no no no no 18:0/18:1-PG+blood L-Glutamine+blood 0 0 -0.625982906 serum_phospholipids serum_aminoacids 0.000842 0.639 no up no no no no 18:0/18:2-PC+blood L-Glutamine+blood 0 0 0.584957265 serum_phospholipids serum_aminoacids 1.74E-06 0.639 no up up no no no 18:0/18:2-PI+blood L-Glutamine+blood -0.457142857 0 0 serum_phospholipids serum_aminoacids 0.179 0.639 no no no no no no 18:0/20:5-PC+blood L-Glutamine+blood 0 0 0.478974359 serum_phospholipids serum_aminoacids 0.17 0.639 no no no no no no 18:0/22:6-PC+blood L-Glutamine+blood 0 0 0.464615385 serum_phospholipids serum_aminoacids 0.0775 0.639 no no up no no no 18:0/22:6-PE+blood L-Glutamine+blood -0.452631579 -0.637254902 0 serum_phospholipids serum_aminoacids 0.00022 0.639 up up no no no no 18:0/22:6-PI+blood L-Glutamine+blood -0.54887218 0 0 serum_phospholipids serum_aminoacids 0.425 0.639 no no no no no no 18:0+blood L-Glutamine+blood 0 -0.634803922 0 serum_fattyacid serum_aminoacids 0.344 0.639 no no no no no no 18:1/16:0-PC+blood L-Glutamine+blood 0 0 0.596581197 serum_phospholipids serum_aminoacids 2.43E-05 0.639 no up up no no no 18:1/16:0-PE+blood L-Glutamine+blood 0 0 -0.459145299 serum_phospholipids serum_aminoacids 0.000182 0.639 up up no no no no 18:1/16:0-PI+blood L-Glutamine+blood -0.445112782 0 0 serum_phospholipids serum_aminoacids 0.793 0.639 no no no no no no 18:1/18:0-PC+blood L-Glutamine+blood 0 0 0.573333333 serum_phospholipids serum_aminoacids 1.83E-06 0.639 no up up no no no 18:1/18:0-PS+blood L-Glutamine+blood 0 -0.617647059 0 serum_phospholipids serum_aminoacids 0.193 0.639 no no no no no no 18:1/18:1-PE+blood L-Glutamine+blood 0 -0.512254902 0 serum_phospholipids serum_aminoacids 1.03E-05 0.639 up up no no no no 18:1/20:4-PC+blood L-Glutamine+blood 0 0 0.423589744 serum_phospholipids serum_aminoacids 0.582 0.639 no no no no no no 18:1/20:4-PE+blood L-Glutamine+blood 0 -0.629901961 0 serum_phospholipids serum_aminoacids 0.0578 0.639 up no no no no no 18:1/22:6-PE+blood L-Glutamine+blood 0 0 0.502222222 serum_phospholipids serum_aminoacids 0.0047 0.639 no up no no no no 18:2-LPA+blood L-Glutamine+blood 0 0.598039216 0 serum_phospholipids serum_aminoacids 0.00684 0.639 dn no up no no no 18:2/16:0-PC+blood L-Glutamine+blood 0 0 0.454358974 serum_phospholipids serum_aminoacids 8.67E-05 0.639 no up up no no no 18:3/16:0-PE+blood L-Glutamine+blood 0 0 -0.563076923 serum_phospholipids serum_aminoacids 0.00149 0.639 up up no no no no 18:3n6+blood L-Glutamine+blood 0 0 -0.424957265 serum_fattyacid serum_aminoacids 0.0463 0.639 up no dn no no no 20:0/20:4-PE+blood L-Glutamine+blood 0 0 -0.461880342 serum_phospholipids serum_aminoacids 0.00128 0.639 up up no no no no 20:1-LPC+blood L-Glutamine+blood 0 0 0.444786325 serum_phospholipids serum_aminoacids 0.217 0.639 no no no no no no 20:1/20:4-PC+blood L-Glutamine+blood 0 0 0.506324786 serum_phospholipids serum_aminoacids 0.0419 0.639 no no up no no no 20:1/20:4-PE+blood L-Glutamine+blood 0 -0.602941176 -0.420854701 serum_phospholipids serum_aminoacids 0.0042 0.639 up up no no no no 20:2/18:1-PE+blood L-Glutamine+blood -0.541353383 -0.514705882 -0.466666667 serum_phospholipids serum_aminoacids 0.00208 0.639 up up no no no no 20:3/16:0-PC+blood L-Glutamine+blood 0.50075188 0 0.406495726 serum_phospholipids serum_aminoacids 0.00405 0.639 no up up no no no 20:3/18:0-PC+blood L-Glutamine+blood 0 0 0.48991453 serum_phospholipids serum_aminoacids 0.296 0.639 no no no no no no 20:4/16:0-PE+blood L-Glutamine+blood 0 0 -0.451623932 serum_phospholipids serum_aminoacids 0.00529 0.639 no up up no no no 20:4/18:0-PE+blood L-Glutamine+blood 0 -0.62254902 0 serum_phospholipids serum_aminoacids 0.000755 0.639 up up no no no no 20:5/18:0-PC+blood L-Glutamine+blood 0 0 0.576068376 serum_phospholipids serum_aminoacids 3.97E-06 0.639 no up up no no no 24:1+blood L-Glutamine+blood 0.547368421 0 0.48991453 serum_fattyacid serum_aminoacids 0.00582 0.639 no dn dn no no no Adipocytokine signaling pathway L-Glutamine+blood 0.664912281 0 0 kegg serum_aminoacids NA 0.639 no no no no no no Aldosterone synthesis and secretion L-Glutamine+blood 0 0 -0.450769231 kegg serum_aminoacids NA 0.639 no up up no no no Alistipes L-Glutamine+blood 0.526796204 0 0 Genus serum_aminoacids 0.0114 0.639 no up no no no no Amphetamine addiction L-Glutamine+blood 0 0 -0.47 kegg serum_aminoacids NA 0.639 no no no no no no Asthma L-Glutamine+blood 0.473684211 0 0 kegg serum_aminoacids NA 0.639 no no no no no no Betaine+blood L-Glutamine+blood 0 0.566176471 0.680683761 serum_choline serum_aminoacids 0.857 0.639 no no no no no no Biosynthesis of amino acids L-Glutamine+blood 0 0 0.445384615 kegg serum_aminoacids NA 0.639 no no no no no no Blautia L-Glutamine+blood 0 0.593137255 0 acetate-producing Genus serum_aminoacids 1.36E-05 0.639 up dn dn no no no Butyricimonas L-Glutamine+blood 0 -0.505395297 0 butyrate-producing Genus serum_aminoacids 0.17 0.639 no no no no no no CA+blood L-Glutamine+blood 0 0 -0.421614831 serum_bileacids serum_aminoacids 0.606 0.639 no no no no no no Calcium signaling pathway L-Glutamine+blood 0 0 -0.469230769 kegg serum_aminoacids NA 0.639 no up up no no no capric acid C6+blood L-Glutamine+blood 0 0 0.427008547 serum_scfa serum_aminoacids 0.433 0.639 no no no no no no Carbon metabolism L-Glutamine+blood 0 0 0.566153846 kegg serum_aminoacids NA 0.639 no no no no no no Cell cycle L-Glutamine+blood -0.622807018 0 0 kegg serum_aminoacids NA 0.639 no no no no no no Central carbon metabolism in cancer L-Glutamine+blood -0.514035088 0 0 kegg serum_aminoacids NA 0.639 no no no no no no Chemical carcinogenesis - receptor activation L-Glutamine+blood 0 0 -0.474615385 kegg serum_aminoacids NA 0.639 no no no no no no Choline+blood L-Glutamine+blood 0 0.68872549 0 serum_choline serum_aminoacids 0.0395 0.639 no up no no no no Cocaine addiction L-Glutamine+blood 0 0 -0.468461538 kegg serum_aminoacids NA 0.639 no no no no no no Cortisol synthesis and secretion L-Glutamine+blood 0 0 -0.561538462 kegg serum_aminoacids NA 0.639 no no up no no no Creatinine+blood L-Glutamine+blood 0.514285714 0.62254902 0.489230769 serum_choline serum_aminoacids 0.437 0.639 no no no no no no Cushing syndrome L-Glutamine+blood 0 0 -0.499230769 kegg serum_aminoacids NA 0.639 no no up no no no Cystine+blood L-Glutamine+blood 0.751879699 0 0.472136752 yes serum_aminoacids serum_aminoacids 0.00028 0.639 up up no no no no d18:1-14:0-SM+blood L-Glutamine+blood 0 0 -0.472136752 serum_phospholipids serum_aminoacids 0.94 0.639 no no no no no no d18:1-14:1-SM+blood L-Glutamine+blood -0.508270677 0 -0.536410256 serum_phospholipids serum_aminoacids 0.0952 0.639 no dn no no no no d18:1-16:1-SM+blood L-Glutamine+blood 0 0 -0.483760684 serum_phospholipids serum_aminoacids 0.2 0.639 no no no no no no DCA+blood L-Glutamine+blood 0 0 -0.432478632 serum_bileacids serum_aminoacids 0.122 0.639 no no no no no no DHA+blood L-Glutamine+blood -0.542857143 0 0 serum_ARA serum_aminoacids 0.872 0.639 no no no no no no DL-methionine sulfoxide+blood L-Glutamine+blood 0 0.600490196 0 serum_aminoacids serum_aminoacids 0.302 0.639 no no no no no no DMG+blood L-Glutamine+blood 0 0 0.539145299 serum_choline serum_aminoacids 0.909 0.639 no no no no no no DPA+blood L-Glutamine+blood -0.470676692 0 0 serum_ARA serum_aminoacids 0.519 0.639 no no no no no no Endocrine and other factor-regulated calcium reabsorption L-Glutamine+blood 0 0 -0.443846154 kegg serum_aminoacids NA 0.639 no no no no no no Endocrine resistance L-Glutamine+blood 0 0 -0.508461538 kegg serum_aminoacids NA 0.639 no no no no no no Estrogen signaling pathway L-Glutamine+blood -0.726315789 0 0 kegg serum_aminoacids NA 0.639 no no no no no no Ethanolamine+blood L-Glutamine+blood 0.545864662 0 0 serum_aminoacids serum_aminoacids 0.122 0.639 up no no no no no Fc gamma R-mediated phagocytosis L-Glutamine+blood 0 0 0.433846154 kegg serum_aminoacids NA 0.639 no no no no no no Gap junction L-Glutamine+blood 0 0 -0.422307692 kegg serum_aminoacids NA 0.639 no no no no no no GLCA+blood L-Glutamine+blood 0.501987068 0 0 serum_bileacids serum_aminoacids 0.319 0.639 no no no no no no Glioma L-Glutamine+blood 0 -0.511764706 0 kegg serum_aminoacids NA 0.639 no no no no no no Glycine+blood L-Glutamine+blood 0.529323308 0.524509804 0.606153846 serum_aminoacids serum_aminoacids 0.00408 0.639 dn no up no no no Glycolysis / Gluconeogenesis L-Glutamine+blood 0 0 0.403846154 kegg serum_aminoacids NA 0.639 no no no no no no GPC+blood L-Glutamine+blood 0 0.776960784 0 serum_choline serum_aminoacids 0.00427 0.639 no up up no no no "Growth hormone synthesis, secretion and action" L-Glutamine+blood 0 0 -0.509230769 kegg serum_aminoacids NA 0.639 no no no no no no Hepatitis C L-Glutamine+blood 0 0.511764706 0 kegg serum_aminoacids NA 0.639 no no no no no no heptanoic acid C7+blood L-Glutamine+blood 0 0 0.44 serum_mcfa serum_aminoacids 8.27E-11 0.639 dn dn no no no no Hypotaurine+blood L-Glutamine+blood 0 0.519607843 0 serum_aminoacids serum_aminoacids 0.933 0.639 no no no no no no Inflammatory mediator regulation of TRP channels L-Glutamine+blood 0 0 -0.46 kegg serum_aminoacids NA 0.639 no no no no no no Influenza A L-Glutamine+blood 0.5 0 0 kegg serum_aminoacids NA 0.639 no no no no no no Insulin secretion L-Glutamine+blood 0 0 -0.492307692 yes kegg serum_aminoacids NA 0.639 no up up no no no Kaposi sarcoma-associated herpesvirus infection L-Glutamine+blood 0.487719298 0 0 kegg serum_aminoacids NA 0.639 no no dn no no no L-Alanine+blood L-Glutamine+blood 0.590977444 0 0 yes serum_aminoacids serum_aminoacids 0.00138 0.639 up up no no no no L-Arginine+blood L-Glutamine+blood 0.527819549 0 0.667692308 serum_aminoacids serum_aminoacids 0.316 0.639 no no no no no no L-Asparagine+blood L-Glutamine+blood 0.745864662 0.666666667 0.753162393 serum_aminoacids serum_aminoacids 0.784 0.639 no no no no no no L-Aspartic acid+blood L-Glutamine+blood 0.606015038 0.556372549 0 yes serum_aminoacids serum_aminoacids 0.0226 0.639 up up no no no no L-Citrulline+blood L-Glutamine+blood 0.560902256 0 0.424273504 serum_aminoacids serum_aminoacids 0.534 0.639 no no no no no no L-Glutamic acid+blood L-Glutamine+blood 0.50075188 0.534313725 0 yes serum_aminoacids serum_aminoacids 6.20E-05 0.639 up up no no no no Long-term depression L-Glutamine+blood 0 0 -0.450769231 kegg serum_aminoacids NA 0.639 no no no no no no Longevity regulating pathway - multiple species L-Glutamine+blood -0.705263158 0 0 kegg serum_aminoacids NA 0.639 no no no no no no Lysosome L-Glutamine+blood 0 0 0.413076923 kegg serum_aminoacids NA 0.639 no no no no no no Malaria L-Glutamine+blood 0.514035088 0 0 kegg serum_aminoacids NA 0.639 no no no no no no MAPK signaling pathway L-Glutamine+blood -0.50877193 0 0 kegg serum_aminoacids NA 0.639 no no no no no no Measles L-Glutamine+blood 0 0.729411765 0 kegg serum_aminoacids NA 0.639 no no no no no no Melanogenesis L-Glutamine+blood 0 0 -0.440769231 kegg serum_aminoacids NA 0.639 no no no no no no Morphine addiction L-Glutamine+blood 0 0 -0.407692308 kegg serum_aminoacids NA 0.639 no up up no no no Non-alcoholic fatty liver disease L-Glutamine+blood 0 0 -0.437692308 kegg serum_aminoacids NA 0.639 no no no no no no Oocyte meiosis L-Glutamine+blood -0.459649123 0 0 kegg serum_aminoacids NA 0.639 no no no no no no Pancreatic cancer L-Glutamine+blood 0 0 -0.434615385 kegg serum_aminoacids NA 0.639 no no no no no no Pancreatic secretion L-Glutamine+blood 0 0 -0.472307692 kegg serum_aminoacids NA 0.639 no no no no no no Prevotella L-Glutamine+blood 0 -0.614601316 0 acetate-producing Genus serum_aminoacids 0.287 0.639 no no no no no no Primary immunodeficiency L-Glutamine+blood -0.636842105 0 0 kegg serum_aminoacids NA 0.639 no no no no no no Progesterone-mediated oocyte maturation L-Glutamine+blood -0.501754386 0 0 kegg serum_aminoacids NA 0.639 no no no no no no Regulation of lipolysis in adipocytes L-Glutamine+blood 0 0 -0.456923077 kegg serum_aminoacids NA 0.639 no no no no no no Small cell lung cancer L-Glutamine+blood 0 0 -0.432307692 kegg serum_aminoacids NA 0.639 no no up no no no Spliceosome L-Glutamine+blood -0.471929825 0 0 kegg serum_aminoacids NA 0.639 no no no no no no Th1 and Th2 cell differentiation L-Glutamine+blood 0.598245614 0 0 kegg serum_aminoacids NA 0.639 no no no no no no Th17 cell differentiation L-Glutamine+blood 0.514035088 0.514705882 0 kegg serum_aminoacids NA 0.639 no no no no no no Vasopressin-regulated water reabsorption L-Glutamine+blood 0 0 -0.410769231 kegg serum_aminoacids NA 0.639 no no no no no no 13-HODE+blood L-Histidine+blood 0.484210526 0 0 serum_ARA serum_aminoacids 0.32 0.109 no no no no no no 14:0/18:2-PC+blood L-Histidine+blood 0 0 -0.455726496 serum_phospholipids serum_aminoacids 0.102 0.109 no up no no no no 14:0/20:4-PC+blood L-Histidine+blood 0 0 -0.462564103 serum_phospholipids serum_aminoacids 0.486 0.109 no no no no no no 14:1/18:2-PG+blood L-Histidine+blood 0 0 -0.42017094 serum_phospholipids serum_aminoacids 0.00259 0.109 no up up no no no 16:0-LPC+blood L-Histidine+blood 0.467669173 0 0 serum_phospholipids serum_aminoacids 0.00456 0.109 up up no no no no 16:0/14:0-PC+blood L-Histidine+blood 0.497744361 0 0 serum_phospholipids serum_aminoacids 0.0206 0.109 no up up no no no 16:0/18:0-PS+blood L-Histidine+blood 0 -0.821078431 0 serum_phospholipids serum_aminoacids 0.377 0.109 no no no no no no 16:0/18:2-PC+blood L-Histidine+blood 0.533834586 0 0.422222222 serum_phospholipids serum_aminoacids 3.24E-06 0.109 no up up no no no 16:0/18:2-PI+blood L-Histidine+blood 0 0 -0.414017094 serum_phospholipids serum_aminoacids 0.269 0.109 no no no no no no 16:0/18:3-PC+blood L-Histidine+blood 0 0 -0.446837607 serum_phospholipids serum_aminoacids 0.00216 0.109 no up up no no no 16:0/20:3-PC+blood L-Histidine+blood 0.511278195 0 0 serum_phospholipids serum_aminoacids 5.43E-06 0.109 no up up no no no 16:0/20:4-PC+blood L-Histidine+blood 0.455639098 0 0 serum_phospholipids serum_aminoacids 0.0262 0.109 no up no no no no 16:0/20:4-PI+blood L-Histidine+blood 0 0 -0.610940171 serum_phospholipids serum_aminoacids 0.558 0.109 no no no no no no 16:0/20:5-PC+blood L-Histidine+blood 0 -0.644607843 0 serum_phospholipids serum_aminoacids 0.628 0.109 no no no no no no 16:0/22:6-PE+blood L-Histidine+blood 0 -0.68872549 0 serum_phospholipids serum_aminoacids 0.000934 0.109 up up no no no no 16:1/16:0-PC+blood L-Histidine+blood 0.538345865 0 0 serum_phospholipids serum_aminoacids 0.0215 0.109 no up up no no no 16:1/18:2-PG+blood L-Histidine+blood 0.511278195 0 0 serum_phospholipids serum_aminoacids 1.40E-08 0.109 no up up no no no 18:0-LPE+blood L-Histidine+blood -0.529323308 0 0 serum_phospholipids serum_aminoacids 0.491 0.109 no no no no no no 18:0/18:0-PE+blood L-Histidine+blood -0.603007519 0 0 serum_phospholipids serum_aminoacids 0.00896 0.109 up up no no no no 18:0/18:0-PS+blood L-Histidine+blood 0 -0.862745098 0 serum_phospholipids serum_aminoacids 0.00617 0.109 no up no no no no 18:0/18:1-PE+blood L-Histidine+blood -0.603007519 0 0 serum_phospholipids serum_aminoacids 0.00716 0.109 up up no no no no 18:0/18:1-PG+blood L-Histidine+blood 0 0 -0.406495726 serum_phospholipids serum_aminoacids 0.000842 0.109 no up no no no no 18:0/20:3-PI+blood L-Histidine+blood 0.45112782 0 0 serum_phospholipids serum_aminoacids 0.377 0.109 no no no no no no 18:0/22:6-PE+blood L-Histidine+blood 0 -0.803921569 0 serum_phospholipids serum_aminoacids 0.00022 0.109 up up no no no no 18:0/22:6-PI+blood L-Histidine+blood 0 -0.593137255 0 serum_phospholipids serum_aminoacids 0.425 0.109 no no no no no no 18:1-LPC+blood L-Histidine+blood 0 0.539215686 0 serum_phospholipids serum_aminoacids 0.179 0.109 no no no no no no 18:1-LPE+blood L-Histidine+blood -0.494736842 0 0 serum_phospholipids serum_aminoacids 0.117 0.109 no no no no no no 18:1/16:0-PC+blood L-Histidine+blood 0.488721805 0 0.439316239 serum_phospholipids serum_aminoacids 2.43E-05 0.109 no up up no no no 18:1/16:0-PE+blood L-Histidine+blood -0.506766917 0 0 serum_phospholipids serum_aminoacids 0.000182 0.109 up up no no no no 18:1/18:0-PE+blood L-Histidine+blood 0 0 -0.405128205 serum_phospholipids serum_aminoacids 1.39E-06 0.109 up up no no no no 18:1/18:0-PS+blood L-Histidine+blood 0 -0.605392157 0 serum_phospholipids serum_aminoacids 0.193 0.109 no no no no no no 18:1/18:1-PE+blood L-Histidine+blood 0 0 -0.424957265 serum_phospholipids serum_aminoacids 1.03E-05 0.109 up up no no no no 18:1/20:3-PC+blood L-Histidine+blood 0 0.629901961 0 serum_phospholipids serum_aminoacids 0.00872 0.109 no up up no no no 18:1/20:4-PE+blood L-Histidine+blood 0 -0.676470588 0 serum_phospholipids serum_aminoacids 0.0578 0.109 up no no no no no 18:3/16:0-PE+blood L-Histidine+blood 0 0 -0.465982906 serum_phospholipids serum_aminoacids 0.00149 0.109 up up no no no no 18:3n6+blood L-Histidine+blood -0.553383459 0 -0.426324786 serum_fattyacid serum_aminoacids 0.0463 0.109 up no dn no no no 20:0/20:4-PE+blood L-Histidine+blood 0 0 -0.455726496 serum_phospholipids serum_aminoacids 0.00128 0.109 up up no no no no 20:1-LPA+blood L-Histidine+blood 0.466165414 0 0.443418803 serum_phospholipids serum_aminoacids 0.0187 0.109 dn dn no no no no 20:1-LPC+blood L-Histidine+blood 0 0.519607843 0 serum_phospholipids serum_aminoacids 0.217 0.109 no no no no no no 20:1/20:4-PE+blood L-Histidine+blood 0 -0.598039216 -0.446837607 serum_phospholipids serum_aminoacids 0.0042 0.109 up up no no no no 20:2-LPC+blood L-Histidine+blood 0.518796992 0 0 serum_phospholipids serum_aminoacids 0.119 0.109 no no up no no no 20:2/18:1-PE+blood L-Histidine+blood 0 0 -0.457094017 serum_phospholipids serum_aminoacids 0.00208 0.109 up up no no no no 20:3/16:0-PC+blood L-Histidine+blood 0.45112782 0 0 serum_phospholipids serum_aminoacids 0.00405 0.109 no up up no no no 20:4/16:0-PE+blood L-Histidine+blood -0.460150376 0 0 serum_phospholipids serum_aminoacids 0.00529 0.109 no up up no no no 20:4/18:0-PE+blood L-Histidine+blood 0 -0.629901961 0 serum_phospholipids serum_aminoacids 0.000755 0.109 up up no no no no 20:5n3+blood L-Histidine+blood 0 -0.605392157 0 serum_fattyacid serum_aminoacids 0.988 0.109 no no no no no no 22:1-LPA+blood L-Histidine+blood 0.478195489 0 0 serum_phospholipids serum_aminoacids 0.00373 0.109 no up up no no no 22:6n3+blood L-Histidine+blood 0 -0.529411765 0 serum_fattyacid serum_aminoacids 0.792 0.109 no no no no no no 8-HETE+blood L-Histidine+blood 0 0.5 0 serum_ARA serum_aminoacids 0.741 0.109 no no no no no no Acetic acid+stool L-Histidine+blood 0 0.681818182 0 yes stool_scfa serum_aminoacids 0.0656 0.109 dn no no no no no Adipocytokine signaling pathway L-Histidine+blood 0 0.55 0 kegg serum_aminoacids NA 0.109 no no no no no no Adrenergic signaling in cardiomyocytes L-Histidine+blood 0 0 -0.404615385 kegg serum_aminoacids NA 0.109 no no up no no no Alzheimer disease L-Histidine+blood 0 0 -0.411538462 kegg serum_aminoacids NA 0.109 no no no no no no Amphetamine addiction L-Histidine+blood 0 0 -0.456153846 kegg serum_aminoacids NA 0.109 no no no no no no Amyotrophic lateral sclerosis L-Histidine+blood 0 0 -0.455384615 kegg serum_aminoacids NA 0.109 no no no no no no Betaine+blood L-Histidine+blood 0 0 0.593162393 serum_choline serum_aminoacids 0.857 0.109 no no no no no no Butyric acid+stool L-Histidine+blood 0 0.618181818 0 yes stool_scfa serum_aminoacids 0.102 0.109 dn no no no no no Butyricimonas L-Histidine+blood 0 0 0.471656671 butyrate-producing Genus serum_aminoacids 0.17 0.109 no no no no no no Calcium signaling pathway L-Histidine+blood 0 0 -0.449230769 kegg serum_aminoacids NA 0.109 no up up no no no cAMP signaling pathway L-Histidine+blood 0 0.567647059 0 yes kegg serum_aminoacids NA 0.109 no up up no no no Cardiac muscle contraction L-Histidine+blood 0 0 -0.433846154 kegg serum_aminoacids NA 0.109 no no up no no no Choline+blood L-Histidine+blood 0.593984962 0.620098039 0.403760684 serum_choline serum_aminoacids 0.0395 0.109 no up no no no no Chronic myeloid leukemia L-Histidine+blood 0 0.597058824 0 kegg serum_aminoacids NA 0.109 no no no no no no Clostridium L-Histidine+blood 0 -0.594283918 0 Genus serum_aminoacids 0.925 0.109 no no no no no no Cocaine addiction L-Histidine+blood 0 0 -0.413846154 kegg serum_aminoacids NA 0.109 no no no no no no Creatinine+blood L-Histidine+blood 0.639097744 0 0.563760684 serum_choline serum_aminoacids 0.437 0.109 no no no no no no Cysteine+blood L-Histidine+blood 0.733834586 0 0.567863248 yes serum_aminoacids serum_aminoacids 1.81E-07 0.109 dn up up no no no Cystine+blood L-Histidine+blood 0 0.490196078 0 yes serum_aminoacids serum_aminoacids 0.00028 0.109 up up no no no no Cytosolic DNA-sensing pathway L-Histidine+blood 0 0.605882353 0 kegg serum_aminoacids NA 0.109 no no no no no no d18:0-24:1-SM+blood L-Histidine+blood -0.469172932 0 0 serum_phospholipids serum_aminoacids 0.0609 0.109 no dn dn no no no d18:1-14:0-SM+blood L-Histidine+blood 0 0 -0.452307692 serum_phospholipids serum_aminoacids 0.94 0.109 no no no no no no d18:1-14:1-SM+blood L-Histidine+blood 0 0 -0.481025641 serum_phospholipids serum_aminoacids 0.0952 0.109 no dn no no no no d18:1-16:1-SM+blood L-Histidine+blood 0 0 -0.478974359 serum_phospholipids serum_aminoacids 0.2 0.109 no no no no no no DCA+blood L-Histidine+blood 0 0.526960784 0 serum_bileacids serum_aminoacids 0.122 0.109 no no no no no no DL-methionine sulfoxide+blood L-Histidine+blood 0 0.593137255 0 serum_aminoacids serum_aminoacids 0.302 0.109 no no no no no no Ethanolamine+blood L-Histidine+blood 0 0.666666667 0.441367521 serum_aminoacids serum_aminoacids 0.122 0.109 up no no no no no Gap junction L-Histidine+blood 0 0 -0.432307692 kegg serum_aminoacids NA 0.109 no no no no no no GCDCA+stool L-Histidine+blood 0 0 -0.593984962 yes stool_bileacids serum_aminoacids 0.0471 0.109 no dn no no no no GDCA+stool L-Histidine+blood 0 0 -0.472892103 stool_bileacids serum_aminoacids 0.656 0.109 no no no no no no Glycine+blood L-Histidine+blood 0 0.529411765 0 serum_aminoacids serum_aminoacids 0.00408 0.109 dn no up no no no GPC+blood L-Histidine+blood 0 0.50245098 0 serum_choline serum_aminoacids 0.00427 0.109 no up up no no no HDCA+blood L-Histidine+blood 0.518101712 0 0 serum_bileacids serum_aminoacids 0.483 0.109 no no no no no no Hepatitis C L-Histidine+blood 0 0.594117647 0 kegg serum_aminoacids NA 0.109 no no no no no no heptanoic acid C7+blood L-Histidine+blood 0 0.509803922 0 serum_mcfa serum_aminoacids 8.27E-11 0.109 dn dn no no no no Hypotaurine+blood L-Histidine+blood 0 0.710784314 0 serum_aminoacids serum_aminoacids 0.933 0.109 no no no no no no Insulin resistance L-Histidine+blood 0 0.520588235 0 kegg serum_aminoacids NA 0.109 no no no no no no iso-DCA+blood L-Histidine+blood 0.505263158 0 0 serum_bileacids serum_aminoacids 0.38 0.109 no no no no no no iso-heptanoic acid C7+blood L-Histidine+blood -0.479699248 0 0 serum_mcfa serum_aminoacids 0.00256 0.109 up up no no no no Kaposi sarcoma-associated herpesvirus infection L-Histidine+blood 0 0.555882353 0 kegg serum_aminoacids NA 0.109 no no dn no no no L-Arginine+blood L-Histidine+blood 0.586466165 0 0.575384615 serum_aminoacids serum_aminoacids 0.316 0.109 no no no no no no L-Asparagine+blood L-Histidine+blood 0 0.81127451 0.672478632 serum_aminoacids serum_aminoacids 0.784 0.109 no no no no no no L-Citrulline+blood L-Histidine+blood 0 0.615196078 0.505641026 serum_aminoacids serum_aminoacids 0.534 0.109 no no no no no no L-Glutamine+blood L-Histidine+blood 0 0.691176471 0.587692308 serum_aminoacids serum_aminoacids 0.639 0.109 no no no no no no Long-term depression L-Histidine+blood 0 0 -0.417692308 kegg serum_aminoacids NA 0.109 no no no no no no Melanogenesis L-Histidine+blood 0 0 -0.416923077 kegg serum_aminoacids NA 0.109 no no no no no no Neurotrophin signaling pathway L-Histidine+blood 0 0.514705882 0 kegg serum_aminoacids NA 0.109 no no no no no no Non-alcoholic fatty liver disease L-Histidine+blood 0 0 -0.483076923 kegg serum_aminoacids NA 0.109 no no no no no no Pancreatic secretion L-Histidine+blood 0 0 -0.406923077 kegg serum_aminoacids NA 0.109 no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer L-Histidine+blood 0 0.505882353 0 kegg serum_aminoacids NA 0.109 no no no no no no Prostate cancer L-Histidine+blood 0 0.552941176 0 kegg serum_aminoacids NA 0.109 no no no no no no Renin secretion L-Histidine+blood 0 0 -0.423076923 kegg serum_aminoacids NA 0.109 no no no no no no Small cell lung cancer L-Histidine+blood 0 0.544117647 0 kegg serum_aminoacids NA 0.109 no no up no no no 11-HETE+blood L-Homocystine+blood 0.444687802 0 0 serum_ARA serum_aminoacids 0.464 0.197 no no no no no no 12-ketoDCA+blood L-Homocystine+blood 0 0.546668169 0 serum_bileacids serum_aminoacids 0.517 0.197 no no no no no no 18:0-LPC+blood L-Homocystine+blood 0 0 0.433162393 serum_phospholipids serum_aminoacids 0.554 0.197 no no no no no no 18:0/18:1-PI+blood L-Homocystine+blood 0 -0.485294118 0 serum_phospholipids serum_aminoacids 0.599 0.197 no no no no no no 18:0/20:3-PI+blood L-Homocystine+blood 0 -0.62745098 0 serum_phospholipids serum_aminoacids 0.377 0.197 no no no no no no 18:1-LPE+blood L-Homocystine+blood 0.568421053 0 0 serum_phospholipids serum_aminoacids 0.117 0.197 no no no no no no 18:1/18:2-PI+blood L-Homocystine+blood 0 0 0.44957265 serum_phospholipids serum_aminoacids 0.0164 0.197 dn no up no no no 18:2/18:2-PS+blood L-Homocystine+blood 0 -0.490196078 0 serum_phospholipids serum_aminoacids 0.00674 0.197 up up no no no no 18:3n3+blood L-Homocystine+blood 0 0 0.429059829 serum_fattyacid serum_aminoacids 0.291 0.197 no no no no no no 20:0-LPE+blood L-Homocystine+blood 0 0 0.444102564 serum_phospholipids serum_aminoacids 0.0615 0.197 no no up no no no 20:1-LPA+blood L-Homocystine+blood -0.446616541 0 0 serum_phospholipids serum_aminoacids 0.0187 0.197 dn dn no no no no 20:1-LPE+blood L-Homocystine+blood 0.457142857 0 0 serum_phospholipids serum_aminoacids 0.465 0.197 no no no no no no 20:3n6+blood L-Homocystine+blood 0 0 -0.461880342 serum_fattyacid serum_aminoacids 0.0884 0.197 up no no no no no 20:4/16:0-PE+blood L-Homocystine+blood 0 0 0.465982906 serum_phospholipids serum_aminoacids 0.00529 0.197 no up up no no no 22:6n3+blood L-Homocystine+blood 0 0 -0.431111111 serum_fattyacid serum_aminoacids 0.792 0.197 no no no no no no 24:0+blood L-Homocystine+blood -0.460150376 0 -0.550769231 serum_fattyacid serum_aminoacids 0.034 0.197 dn no up no no no 3-(3-Hydroxyphenyl)propanoic acid+stool L-Homocystine+blood 0 -0.618181818 0 stool_cometabolism serum_aminoacids 0.33 0.197 no no no no no no 4-hydroxybenzoic acid+stool L-Homocystine+blood -0.60989011 0 0 stool_cometabolism serum_aminoacids 0.0536 0.197 no dn no no no no 8-HETE+blood L-Homocystine+blood -0.554887218 0 0 serum_ARA serum_aminoacids 0.741 0.197 no no no no no no Acetic acid+stool L-Homocystine+blood -0.576923077 0 0 yes stool_scfa serum_aminoacids 0.0656 0.197 dn no no no no no Adrenergic signaling in cardiomyocytes L-Homocystine+blood 0.587719298 0.511764706 0 kegg serum_aminoacids NA 0.197 no no up no no no Aldosterone synthesis and secretion L-Homocystine+blood 0.471929825 0.567647059 0 kegg serum_aminoacids NA 0.197 no up up no no no Allograft rejection L-Homocystine+blood 0 -0.611764706 -0.450769231 kegg serum_aminoacids NA 0.197 no no no no no no Alzheimer disease L-Homocystine+blood 0.650877193 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Amyotrophic lateral sclerosis L-Homocystine+blood 0.607017544 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Antigen processing and presentation L-Homocystine+blood 0 -0.614705882 0 kegg serum_aminoacids NA 0.197 no no no no no no Autoimmune thyroid disease L-Homocystine+blood 0 -0.611764706 -0.450769231 kegg serum_aminoacids NA 0.197 no no no no no no Autophagy - animal L-Homocystine+blood 0.510526316 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Bacterial invasion of epithelial cells L-Homocystine+blood -0.556140351 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Bacteroides L-Homocystine+blood -0.461654135 0 0 LPS-producing Genus serum_aminoacids 0.000267 0.197 dn dn up no no no Biosynthesis of amino acids L-Homocystine+blood -0.596491228 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Blautia L-Homocystine+blood 0 -0.517156863 0 acetate-producing Genus serum_aminoacids 1.36E-05 0.197 up dn dn no no no CA+stool L-Homocystine+blood 0 -0.672727273 0 stool_bileacids serum_aminoacids 0.827 0.197 no no no no no no Calcium signaling pathway L-Homocystine+blood 0.573684211 0.555882353 0 kegg serum_aminoacids NA 0.197 no up up no no no cAMP signaling pathway L-Homocystine+blood 0.628070175 0 0 yes kegg serum_aminoacids NA 0.197 no up up no no no Carbon metabolism L-Homocystine+blood -0.712280702 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Cardiac muscle contraction L-Homocystine+blood 0.635087719 0 0 kegg serum_aminoacids NA 0.197 no no up no no no CDCA+stool L-Homocystine+blood 0 -0.709090909 0 stool_bileacids serum_aminoacids 0.663 0.197 no no no no no no Cell adhesion molecules L-Homocystine+blood 0 -0.670588235 0 kegg serum_aminoacids NA 0.197 no no no no no no Cellular senescence L-Homocystine+blood 0 -0.505882353 -0.421538462 kegg serum_aminoacids NA 0.197 no no no no no no Chagas disease L-Homocystine+blood 0.531578947 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Chemical carcinogenesis - receptor activation L-Homocystine+blood 0.503508772 0.670588235 0 kegg serum_aminoacids NA 0.197 no no no no no no Choline metabolism in cancer L-Homocystine+blood 0.556140351 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Colorectal cancer L-Homocystine+blood 0.475438596 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Cushing syndrome L-Homocystine+blood 0 0.638235294 0 kegg serum_aminoacids NA 0.197 no no up no no no d18:1-20:0-SM+blood L-Homocystine+blood -0.476691729 0 0 serum_phospholipids serum_aminoacids 0.933 0.197 no no no no no no Diabetic cardiomyopathy L-Homocystine+blood 0.633333333 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Dopaminergic synapse L-Homocystine+blood 0.501754386 0.570588235 0 kegg serum_aminoacids NA 0.197 no up no no no no DPA+blood L-Homocystine+blood 0 -0.534313725 0 serum_ARA serum_aminoacids 0.519 0.197 no no no no no no Eggerthella L-Homocystine+blood 0 -0.507149988 0 Genus serum_aminoacids 0.912 0.197 no no no no no no Endocrine resistance L-Homocystine+blood 0.501754386 0.705882353 0 kegg serum_aminoacids NA 0.197 no no no no no no Endocytosis L-Homocystine+blood 0 -0.614705882 -0.480769231 kegg serum_aminoacids NA 0.197 no no no no no no Epstein-Barr virus infection L-Homocystine+blood 0 -0.6 0 kegg serum_aminoacids NA 0.197 no no no no no no Fc gamma R-mediated phagocytosis L-Homocystine+blood -0.463157895 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Ferroptosis L-Homocystine+blood 0 0.517647059 0 kegg serum_aminoacids NA 0.197 no no no no no no FoxO signaling pathway L-Homocystine+blood 0 0 0.536153846 kegg serum_aminoacids NA 0.197 no no no no no no Gap junction L-Homocystine+blood 0 0.5 0 kegg serum_aminoacids NA 0.197 no no no no no no GCA+stool L-Homocystine+blood 0 -0.772727273 0 stool_bileacids serum_aminoacids 0.0809 0.197 no no no no no no GLCA+blood L-Homocystine+blood 0 0 0.468769477 serum_bileacids serum_aminoacids 0.319 0.197 no no no no no no Glycolysis / Gluconeogenesis L-Homocystine+blood -0.568421053 0 0 kegg serum_aminoacids NA 0.197 no no no no no no GnRH signaling pathway L-Homocystine+blood 0 0.723529412 0 kegg serum_aminoacids NA 0.197 no no no no no no GPC+blood L-Homocystine+blood -0.536842105 0 0.463931624 serum_choline serum_aminoacids 0.00427 0.197 no up up no no no Graft-versus-host disease L-Homocystine+blood 0 -0.611764706 -0.425384615 kegg serum_aminoacids NA 0.197 no no no no no no "Growth hormone synthesis, secretion and action" L-Homocystine+blood 0.477192982 0 0 kegg serum_aminoacids NA 0.197 no no no no no no GUDCA+stool L-Homocystine+blood 0 0.66421334 0 yes stool_bileacids serum_aminoacids 0.0085 0.197 no dn no no no no HCA+stool L-Homocystine+blood -0.554945055 0 -0.590977444 stool_bileacids serum_aminoacids 0.155 0.197 no no no no no no HDCA+blood L-Homocystine+blood 0 0.578536772 0 serum_bileacids serum_aminoacids 0.483 0.197 no no no no no no Herpes simplex virus 1 infection L-Homocystine+blood 0 -0.688235294 0 kegg serum_aminoacids NA 0.197 no no no no no no Human cytomegalovirus infection L-Homocystine+blood 0 -0.544117647 0 kegg serum_aminoacids NA 0.197 no no dn no no no Human immunodeficiency virus 1 infection L-Homocystine+blood 0 -0.594117647 0 kegg serum_aminoacids NA 0.197 no no no no no no Human papillomavirus infection L-Homocystine+blood 0 -0.511764706 -0.41 kegg serum_aminoacids NA 0.197 no no no no no no Human T-cell leukemia virus 1 infection L-Homocystine+blood 0 -0.632352941 0 kegg serum_aminoacids NA 0.197 no no no no no no Huntington disease L-Homocystine+blood 0.647368421 0 0 kegg serum_aminoacids NA 0.197 no no no no no no iso-LCA+blood L-Homocystine+blood 0 0.590784383 0 serum_bileacids serum_aminoacids 0.507 0.197 no no no no no no iso-LCA+stool L-Homocystine+blood 0 0.7 0 stool_bileacids serum_aminoacids 0.72 0.197 no no no no no no L-Citrulline+blood L-Homocystine+blood 0.466165414 0 0 serum_aminoacids serum_aminoacids 0.534 0.197 no no no no no no LCA+stool L-Homocystine+blood 0 0.645454545 0 stool_bileacids serum_aminoacids 0.314 0.197 no no no no no no Long-term depression L-Homocystine+blood 0.557894737 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Longevity regulating pathway L-Homocystine+blood 0.573684211 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Longevity regulating pathway - multiple species L-Homocystine+blood 0 -0.685294118 0 kegg serum_aminoacids NA 0.197 no no no no no no Methanobrevibacter L-Homocystine+blood 0 0 0.400056655 Genus serum_aminoacids 0.629 0.197 no no no no no no Mineral absorption L-Homocystine+blood 0 0.611764706 0 kegg serum_aminoacids NA 0.197 no no no no no no Mitophagy - animal L-Homocystine+blood 0.466666667 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Morphine addiction L-Homocystine+blood 0 0.758823529 0 kegg serum_aminoacids NA 0.197 no up up no no no mRNA surveillance pathway L-Homocystine+blood 0.466666667 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Natural killer cell mediated cytotoxicity L-Homocystine+blood -0.554385965 -0.597058824 0 kegg serum_aminoacids NA 0.197 no no no no no no Neuroactive ligand-receptor interaction L-Homocystine+blood 0 -0.508823529 0 kegg serum_aminoacids NA 0.197 up up up no no no Neurotrophin signaling pathway L-Homocystine+blood 0.521052632 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Neutrophil extracellular trap formation L-Homocystine+blood -0.496491228 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Non-alcoholic fatty liver disease L-Homocystine+blood 0.668421053 0 0 kegg serum_aminoacids NA 0.197 no no no no no no nutriCA+stool L-Homocystine+blood -0.571428571 0 0 stool_bileacids serum_aminoacids 0.481 0.197 no no no no no no Oscillospira L-Homocystine+blood 0.562406015 0 0 LPS-producing Genus serum_aminoacids 0.62 0.197 no no no no no no Oxidative phosphorylation L-Homocystine+blood 0.589473684 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Pancreatic cancer L-Homocystine+blood 0 -0.523529412 0 kegg serum_aminoacids NA 0.197 no no no no no no Pancreatic secretion L-Homocystine+blood 0.501754386 0.714705882 0 kegg serum_aminoacids NA 0.197 no no no no no no Paraprevotella L-Homocystine+blood -0.499849457 0 0 Genus serum_aminoacids 0.118 0.197 no no no no no no "Parathyroid hormone synthesis, secretion and action" L-Homocystine+blood 0.575438596 0.570588235 0 kegg serum_aminoacids NA 0.197 no no no no no no Parkinson disease L-Homocystine+blood 0.610526316 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Pathogenic Escherichia coli infection L-Homocystine+blood -0.526315789 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Pathways in cancer L-Homocystine+blood 0.519298246 0 0.468461538 kegg serum_aminoacids NA 0.197 no no no no no no Pathways of neurodegeneration - multiple diseases L-Homocystine+blood 0.60877193 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Platinum drug resistance L-Homocystine+blood 0 0 0.489230769 kegg serum_aminoacids NA 0.197 no no no no no no Prion disease L-Homocystine+blood 0.561403509 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Prostate cancer L-Homocystine+blood 0.584210526 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Relaxin signaling pathway L-Homocystine+blood 0.60877193 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Roseburia L-Homocystine+blood -0.503759398 0 0 butyrate-producing Genus serum_aminoacids 0.495 0.197 no no no no no no Ruminococcus L-Homocystine+blood 0 0 -0.517948718 acetate-producing Genus serum_aminoacids 0.335 0.197 no no no no no no Salmonella infection L-Homocystine+blood -0.640350877 -0.552941176 0 kegg serum_aminoacids NA 0.197 no no no no no no Serotonergic synapse L-Homocystine+blood 0 0.585294118 0 kegg serum_aminoacids NA 0.197 no no no no no no Signaling pathways regulating pluripotency of stem cells L-Homocystine+blood 0.605263158 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Thermogenesis L-Homocystine+blood 0.542105263 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Thyroid hormone synthesis L-Homocystine+blood 0 0.729411765 0 kegg serum_aminoacids NA 0.197 no no no no no no Tight junction L-Homocystine+blood -0.480701754 0 0 kegg serum_aminoacids NA 0.197 no no no no no no Transcriptional misregulation in cancer L-Homocystine+blood 0 0 0.5 kegg serum_aminoacids NA 0.197 no no no no no no Type I diabetes mellitus L-Homocystine+blood 0 -0.611764706 -0.441538462 kegg serum_aminoacids NA 0.197 no no no no no no UDCA+stool L-Homocystine+blood 0 -0.754545455 -0.612030075 stool_bileacids serum_aminoacids 0.266 0.197 no no no no no no Viral myocarditis L-Homocystine+blood 0 -0.638235294 -0.459230769 kegg serum_aminoacids NA 0.197 no no no no no no 12-HEPE+blood L-Isoleucine+blood 0 -0.493977261 0 yes serum_ARA serum_aminoacids 0.312 5.47E-06 no no no up up no 15-HETE+blood L-Isoleucine+blood 0 0 -0.50716447 yes serum_ARA serum_aminoacids 0.819 5.47E-06 no no no up up no 16:0/20:5-PC+blood L-Isoleucine+blood 0 -0.642156863 0 yes serum_phospholipids serum_aminoacids 0.628 5.47E-06 no no no up up no 16:0/22:0-PE+blood L-Isoleucine+blood 0 -0.487745098 0 yes serum_phospholipids serum_aminoacids 0.00839 5.47E-06 dn no up up up no 18:0-LPA+blood L-Isoleucine+blood 0 0.507352941 0 yes serum_phospholipids serum_aminoacids 0.0725 5.47E-06 no dn no up up no 18:0/18:1-PI+blood L-Isoleucine+blood 0 0.517156863 0 yes serum_phospholipids serum_aminoacids 0.599 5.47E-06 no no no up up no 18:1-LPE+blood L-Isoleucine+blood -0.502255639 0 0 yes serum_phospholipids serum_aminoacids 0.117 5.47E-06 no no no up up no 18:3/18:2-PC+blood L-Isoleucine+blood 0 0 -0.413333333 yes serum_phospholipids serum_aminoacids 0.0394 5.47E-06 no no up up up no 20:1-LPA+blood L-Isoleucine+blood 0 0.534313725 0 yes serum_phospholipids serum_aminoacids 0.0187 5.47E-06 dn dn no up up no 20:4-LPE+blood L-Isoleucine+blood 0 0 -0.416068376 yes serum_phospholipids serum_aminoacids 0.552 5.47E-06 no no no up up no 20:4/16:0-PE+blood L-Isoleucine+blood -0.454135338 0 0 yes serum_phospholipids serum_aminoacids 0.00529 5.47E-06 no up up up up no 20:5n3+blood L-Isoleucine+blood 0 -0.605392157 0 yes serum_fattyacid serum_aminoacids 0.988 5.47E-06 no no no up up no 22:1-LPA+blood L-Isoleucine+blood 0.454135338 0 0 yes serum_phospholipids serum_aminoacids 0.00373 5.47E-06 no up up up up no 22:6-LPC+blood L-Isoleucine+blood 0 0 0.502222222 yes serum_phospholipids serum_aminoacids 0.127 5.47E-06 no no up up up no 22:6n3+blood L-Isoleucine+blood 0 0 0.401025641 yes serum_fattyacid serum_aminoacids 0.792 5.47E-06 no no no up up no Adrenergic signaling in cardiomyocytes L-Isoleucine+blood 0 0 -0.468461538 yes kegg serum_aminoacids NA 5.47E-06 no no up up up no Aldosterone synthesis and secretion L-Isoleucine+blood 0 0 -0.421538462 yes kegg serum_aminoacids NA 5.47E-06 no up up up up no Amphetamine addiction L-Isoleucine+blood 0 0 -0.515384615 yes kegg serum_aminoacids NA 5.47E-06 no no no up up no Anaerostipes L-Isoleucine+blood 0 0 -0.42762078 butyrate-producing yes Genus serum_aminoacids 0.568 5.47E-06 no no no up up no Axon guidance L-Isoleucine+blood 0 0 -0.403076923 yes kegg serum_aminoacids NA 5.47E-06 no up up up up no Betaine+blood L-Isoleucine+blood 0 0 0.433846154 yes serum_choline serum_aminoacids 0.857 5.47E-06 no no no up up no Blautia L-Isoleucine+blood 0 0.634803922 0 acetate-producing yes Genus serum_aminoacids 1.36E-05 5.47E-06 up dn dn up up no Butyricimonas L-Isoleucine+blood 0 -0.490157248 0 butyrate-producing yes Genus serum_aminoacids 0.17 5.47E-06 no no no up up no CA+blood L-Isoleucine+blood -0.510718351 0 0 yes serum_bileacids serum_aminoacids 0.606 5.47E-06 no no no up up no CDCA+stool L-Isoleucine+blood 0 0.654545455 0 yes stool_bileacids serum_aminoacids 0.663 5.47E-06 no no no up up no Chemical carcinogenesis - receptor activation L-Isoleucine+blood 0 -0.594117647 0 yes kegg serum_aminoacids NA 5.47E-06 no no no up up no Choline+blood L-Isoleucine+blood 0.452631579 0 0.485811966 yes serum_choline serum_aminoacids 0.0395 5.47E-06 no up no up up no Cholinergic synapse L-Isoleucine+blood 0 -0.735294118 0 yes kegg serum_aminoacids NA 5.47E-06 no no no up up no Clostridium L-Isoleucine+blood 0 0.523605249 0 yes Genus serum_aminoacids 0.925 5.47E-06 no no no up up no Creatinine+blood L-Isoleucine+blood 0.557894737 0.68872549 0.498803419 yes serum_choline serum_aminoacids 0.437 5.47E-06 no no no up up no Cysteine+blood L-Isoleucine+blood 0 0 0.424273504 yes yes serum_aminoacids serum_aminoacids 1.81E-07 5.47E-06 dn up up up up no Cystine+blood L-Isoleucine+blood 0 0.678921569 0 yes yes serum_aminoacids serum_aminoacids 0.00028 5.47E-06 up up no up up no d18:0-16:0-SM+blood L-Isoleucine+blood -0.485714286 0 0 yes serum_phospholipids serum_aminoacids 0.202 5.47E-06 no no no up up no d18:0-18:3-SM+blood L-Isoleucine+blood 0 0 -0.455726496 yes serum_phospholipids serum_aminoacids 0.0879 5.47E-06 no dn no up up no d18:0-24:1-SM+blood L-Isoleucine+blood -0.494736842 0 0 yes serum_phospholipids serum_aminoacids 0.0609 5.47E-06 no dn dn up up no d18:1-14:1-SM+blood L-Isoleucine+blood 0 -0.507352941 -0.405811966 yes serum_phospholipids serum_aminoacids 0.0952 5.47E-06 no dn no up up no d18:1-16:0-SM+blood L-Isoleucine+blood -0.478195489 0 0 yes serum_phospholipids serum_aminoacids 0.14 5.47E-06 no no no up up no d18:1-16:1-SM+blood L-Isoleucine+blood -0.544360902 0 -0.448888889 yes serum_phospholipids serum_aminoacids 0.2 5.47E-06 no no no up up no d18:1-22:1-SM+blood L-Isoleucine+blood -0.523308271 0 0 yes serum_phospholipids serum_aminoacids 0.222 5.47E-06 no no no up up no decanoic acid C10+blood L-Isoleucine+blood 0 0.580882353 0 yes serum_mcfa serum_aminoacids 6.64E-11 5.47E-06 dn dn no up up no DL-methionine sulfoxide+blood L-Isoleucine+blood 0 0.68872549 0.439316239 yes serum_aminoacids serum_aminoacids 0.302 5.47E-06 no no no up up no DMG+blood L-Isoleucine+blood 0 0 0.483760684 yes serum_choline serum_aminoacids 0.909 5.47E-06 no no no up up no Estrogen signaling pathway L-Isoleucine+blood 0 0 -0.400769231 yes kegg serum_aminoacids NA 5.47E-06 no no no up up no Ethanolamine+blood L-Isoleucine+blood 0 0 0.59042735 yes serum_aminoacids serum_aminoacids 0.122 5.47E-06 up no no up up no Gap junction L-Isoleucine+blood 0 0 -0.430769231 yes kegg serum_aminoacids NA 5.47E-06 no no no up up no GCDCA+stool L-Isoleucine+blood 0 0.7 -0.571428571 yes yes stool_bileacids serum_aminoacids 0.0471 5.47E-06 no dn no up up no GDCA+stool L-Isoleucine+blood -0.582417582 0.76537784 -0.548193393 yes stool_bileacids serum_aminoacids 0.656 5.47E-06 no no no up up no Glucagon signaling pathway L-Isoleucine+blood 0 0 -0.404615385 yes kegg serum_aminoacids NA 5.47E-06 no no no up up no GnRH signaling pathway L-Isoleucine+blood 0 0 -0.456153846 yes kegg serum_aminoacids NA 5.47E-06 no no no up up no HCA+blood L-Isoleucine+blood -0.471660975 0 0 yes serum_bileacids serum_aminoacids 0.544 5.47E-06 no no no up up no heptanoic acid C7+blood L-Isoleucine+blood 0 0 0.504957265 yes serum_mcfa serum_aminoacids 8.27E-11 5.47E-06 dn dn no up up no Inflammatory mediator regulation of TRP channels L-Isoleucine+blood 0 0 -0.432307692 yes kegg serum_aminoacids NA 5.47E-06 no no no up up no Intestinal immune network for IgA production L-Isoleucine+blood 0 0 -0.434615385 yes kegg serum_aminoacids NA 5.47E-06 no no no up up no isobutyric acid C4+blood L-Isoleucine+blood 0.562406015 0 0 yes serum_scfa serum_aminoacids 0.0151 5.47E-06 up up no up up no isocapric acid iso-C6+blood L-Isoleucine+blood 0.44962406 0 0 yes serum_scfa serum_aminoacids 0.0458 5.47E-06 no no dn up up no Kaposi sarcoma-associated herpesvirus infection L-Isoleucine+blood 0 0.508823529 0 yes kegg serum_aminoacids NA 5.47E-06 no no dn up up no L-Arginine+blood L-Isoleucine+blood 0.529323308 0 0 yes serum_aminoacids serum_aminoacids 0.316 5.47E-06 no no no up up no L-Asparagine+blood L-Isoleucine+blood 0 0.526960784 0.414017094 yes serum_aminoacids serum_aminoacids 0.784 5.47E-06 no no no up up no L-Citrulline+blood L-Isoleucine+blood 0 0 0.44957265 yes serum_aminoacids serum_aminoacids 0.534 5.47E-06 no no no up up no L-Glutamic acid+blood L-Isoleucine+blood 0.464661654 0.642156863 0 yes yes serum_aminoacids serum_aminoacids 6.20E-05 5.47E-06 up up no up up no L-Glutamine+blood L-Isoleucine+blood 0 0.507352941 0.40991453 yes serum_aminoacids serum_aminoacids 0.639 5.47E-06 no no no up up no L-Histidine+blood L-Isoleucine+blood 0.697744361 0.509803922 0.673162393 yes serum_aminoacids serum_aminoacids 0.109 5.47E-06 no no no up up no Long-term depression L-Isoleucine+blood 0 0 -0.406923077 yes kegg serum_aminoacids NA 5.47E-06 no no no up up no Long-term potentiation L-Isoleucine+blood 0 0 -0.422307692 yes kegg serum_aminoacids NA 5.47E-06 no no up up up no Mineral absorption L-Isoleucine+blood 0.473684211 0 0 yes kegg serum_aminoacids NA 5.47E-06 no no no up up no Parabacteroides L-Isoleucine+blood 0 0 0.515301769 yes Genus serum_aminoacids 4.19E-05 5.47E-06 no up up up up no Phenylacetic acid+stool L-Isoleucine+blood 0 -0.727272727 0 yes stool_cometabolism serum_aminoacids 0.785 5.47E-06 no no no up up no Proteasome L-Isoleucine+blood 0 0 0.427692308 yes kegg serum_aminoacids NA 5.47E-06 no no no up up no 15-HETE+blood L-Leucine+blood 0 0 -0.423909016 yes serum_ARA serum_aminoacids 0.819 3.22E-05 no no no up up no 16:0-LPC+blood L-Leucine+blood 0 0.531862745 0 yes serum_phospholipids serum_aminoacids 0.00456 3.22E-05 up up no up up no 16:1+blood L-Leucine+blood -0.520300752 0 0 yes yes serum_fattyacid serum_aminoacids 0.0186 3.22E-05 no no dn up up no 18:0/18:0-PC+blood L-Leucine+blood 0 -0.492647059 0 yes serum_phospholipids serum_aminoacids 0.426 3.22E-05 no no no up up no 18:0/18:1-PC+blood L-Leucine+blood 0 -0.507352941 0 yes serum_phospholipids serum_aminoacids 0.393 3.22E-05 no no no up up no 18:0/20:2-PC+blood L-Leucine+blood 0 -0.656862745 0 yes serum_phospholipids serum_aminoacids 0.733 3.22E-05 no no no up up no 18:0/20:3-PC+blood L-Leucine+blood 0 -0.50245098 0 yes serum_phospholipids serum_aminoacids 0.0682 3.22E-05 no up no up up no 18:1/20:4-PE+blood L-Leucine+blood 0 0 -0.448205128 yes serum_phospholipids serum_aminoacids 0.0578 3.22E-05 up no no up up no 18:1+blood L-Leucine+blood -0.514285714 0 0 yes yes serum_fattyacid serum_aminoacids 0.00202 3.22E-05 up no dn up up no 18:3n3+blood L-Leucine+blood 0 0.507352941 0 yes serum_fattyacid serum_aminoacids 0.291 3.22E-05 no no no up up no 20:0-LPE+blood L-Leucine+blood 0 -0.495098039 0 yes serum_phospholipids serum_aminoacids 0.0615 3.22E-05 no no up up up no 20:0+blood L-Leucine+blood 0 -0.524509804 0 yes yes serum_fattyacid serum_aminoacids 0.000278 3.22E-05 dn no up up up no 20:1+blood L-Leucine+blood 0 0 0.419487179 yes yes serum_fattyacid serum_aminoacids 2.56E-05 3.22E-05 dn dn dn up up no 20:2-LPE+blood L-Leucine+blood 0 -0.571078431 0 yes serum_phospholipids serum_aminoacids 0.177 3.22E-05 no no no up up no 20:2/18:0-PC+blood L-Leucine+blood 0 -0.526960784 0 yes serum_phospholipids serum_aminoacids 0.0427 3.22E-05 no up no up up no Acetic acid+stool L-Leucine+blood 0.56043956 0 0 yes yes stool_scfa serum_aminoacids 0.0656 3.22E-05 dn no no up up no Akkermansia L-Leucine+blood -0.479607038 0 0 acetate-producing yes Genus serum_aminoacids 0.23 3.22E-05 no no no up up no Antigen processing and presentation L-Leucine+blood -0.529824561 0 0 yes kegg serum_aminoacids NA 3.22E-05 no no no up up no Axon guidance L-Leucine+blood 0 -0.6 0 yes kegg serum_aminoacids NA 3.22E-05 no up up up up no Betaine+blood L-Leucine+blood 0 0.600490196 0 yes serum_choline serum_aminoacids 0.857 3.22E-05 no no no up up no Choline+blood L-Leucine+blood 0 0.588235294 0 yes serum_choline serum_aminoacids 0.0395 3.22E-05 no up no up up no Cholinergic synapse L-Leucine+blood -0.456140351 0 0 yes kegg serum_aminoacids NA 3.22E-05 no no no up up no Creatinine+blood L-Leucine+blood 0 0.693627451 0.416752137 yes serum_choline serum_aminoacids 0.437 3.22E-05 no no no up up no Cysteine+blood L-Leucine+blood 0 0 0.40991453 yes yes serum_aminoacids serum_aminoacids 1.81E-07 3.22E-05 dn up up up up no d18:0-16:0-SM+blood L-Leucine+blood -0.505263158 0 0 yes serum_phospholipids serum_aminoacids 0.202 3.22E-05 no no no up up no d18:0-24:1-SM+blood L-Leucine+blood -0.467669173 0 0 yes serum_phospholipids serum_aminoacids 0.0609 3.22E-05 no dn dn up up no d18:1-14:1-SM+blood L-Leucine+blood 0 -0.553921569 0 yes serum_phospholipids serum_aminoacids 0.0952 3.22E-05 no dn no up up no d18:1-16:0-SM+blood L-Leucine+blood -0.487218045 0 0 yes serum_phospholipids serum_aminoacids 0.14 3.22E-05 no no no up up no d18:1-20:0-SM+blood L-Leucine+blood -0.50075188 0 0 yes serum_phospholipids serum_aminoacids 0.933 3.22E-05 no no no up up no d18:1-20:1-SM+blood L-Leucine+blood -0.532330827 0 0 yes serum_phospholipids serum_aminoacids 0.0992 3.22E-05 no no no up up no d18:1-22:0-SM+blood L-Leucine+blood 0 -0.575980392 0 yes serum_phospholipids serum_aminoacids 0.522 3.22E-05 no no no up up no d18:1-22:1-SM+blood L-Leucine+blood -0.515789474 0 0 yes serum_phospholipids serum_aminoacids 0.222 3.22E-05 no no no up up no DMG+blood L-Leucine+blood 0 0 0.608205128 yes serum_choline serum_aminoacids 0.909 3.22E-05 no no no up up no Epstein-Barr virus infection L-Leucine+blood -0.550877193 0 0 yes kegg serum_aminoacids NA 3.22E-05 no no no up up no Ethanolamine+blood L-Leucine+blood 0 0 0.474188034 yes serum_aminoacids serum_aminoacids 0.122 3.22E-05 up no no up up no Faecalibacterium L-Leucine+blood 0.503759398 0 0 butyrate-producing yes Genus serum_aminoacids 0.0039 3.22E-05 no dn dn up up no Gastric cancer L-Leucine+blood 0 -0.520588235 0 yes kegg serum_aminoacids NA 3.22E-05 no no no up up no GCA+blood L-Leucine+blood 0.44962406 0 0 yes yes serum_bileacids serum_aminoacids 0.16 3.22E-05 no no no up up no GPC+blood L-Leucine+blood 0 0.551470588 0 yes serum_choline serum_aminoacids 0.00427 3.22E-05 no up up up up no heptanoic acid C7+blood L-Leucine+blood 0 0 0.537777778 yes serum_mcfa serum_aminoacids 8.27E-11 3.22E-05 dn dn no up up no Herpes simplex virus 1 infection L-Leucine+blood -0.6 0 0 yes kegg serum_aminoacids NA 3.22E-05 no no no up up no Human cytomegalovirus infection L-Leucine+blood -0.612280702 0 0 yes kegg serum_aminoacids NA 3.22E-05 no no dn up up no Human immunodeficiency virus 1 infection L-Leucine+blood -0.577192982 0 0 yes kegg serum_aminoacids NA 3.22E-05 no no no up up no Human T-cell leukemia virus 1 infection L-Leucine+blood -0.512280702 0 0 yes kegg serum_aminoacids NA 3.22E-05 no no no up up no Intestinal immune network for IgA production L-Leucine+blood 0 0 -0.409230769 yes kegg serum_aminoacids NA 3.22E-05 no no no up up no iso-DCA+blood L-Leucine+blood 0 0 0.474188034 yes serum_bileacids serum_aminoacids 0.38 3.22E-05 no no no up up no isobutyric acid C4+blood L-Leucine+blood 0.545864662 0 0 yes serum_scfa serum_aminoacids 0.0151 3.22E-05 up up no up up no L-Alanine+blood L-Leucine+blood 0 0.637254902 0 yes yes serum_aminoacids serum_aminoacids 0.00138 3.22E-05 up up no up up no L-Arginine+blood L-Leucine+blood 0 0.509803922 0.446837607 yes serum_aminoacids serum_aminoacids 0.316 3.22E-05 no no no up up no L-Asparagine+blood L-Leucine+blood 0 0.571078431 0 yes serum_aminoacids serum_aminoacids 0.784 3.22E-05 no no no up up no L-Citrulline+blood L-Leucine+blood 0 0 0.624615385 yes serum_aminoacids serum_aminoacids 0.534 3.22E-05 no no no up up no L-Glutamic acid+blood L-Leucine+blood 0 0.585784314 0 yes yes serum_aminoacids serum_aminoacids 6.20E-05 3.22E-05 up up no up up no L-Histidine+blood L-Leucine+blood 0 0 0.534358974 yes serum_aminoacids serum_aminoacids 0.109 3.22E-05 no no no up up no L-Isoleucine+blood L-Leucine+blood 0.745864662 0.691176471 0.79008547 yes yes serum_aminoacids serum_aminoacids 5.47E-06 3.22E-05 up up no up up no Lachnospira L-Leucine+blood 0.49924812 0 0 butyrate-producing yes Genus serum_aminoacids 0.279 3.22E-05 no no no up up no Methanobrevibacter L-Leucine+blood 0 0 0.50673843 yes Genus serum_aminoacids 0.629 3.22E-05 no no no up up no Parabacteroides L-Leucine+blood 0 -0.529411765 0.47803044 yes Genus serum_aminoacids 4.19E-05 3.22E-05 no up up up up no Prevotella L-Leucine+blood 0 0 0.453065624 acetate-producing yes Genus serum_aminoacids 0.287 3.22E-05 no no no up up no Viral protein interaction with cytokine and cytokine receptor L-Leucine+blood -0.456140351 0 0 yes kegg serum_aminoacids NA 3.22E-05 no no no up up no 12-ketoDCA+blood L-Lysine+blood 0 0 -0.401415311 yes serum_bileacids serum_aminoacids 0.517 0.0107 no no no no up no 14:0/18:0-PC+blood L-Lysine+blood -0.527819549 0 0 yes serum_phospholipids serum_aminoacids 0.00289 0.0107 up up no no up no 14:0/20:4-PC+blood L-Lysine+blood -0.523308271 0 0 yes serum_phospholipids serum_aminoacids 0.486 0.0107 no no no no up no 16:0/14:0-PC+blood L-Lysine+blood 0 0 0.440683761 yes serum_phospholipids serum_aminoacids 0.0206 0.0107 no up up no up no 16:0/16:1-PI+blood L-Lysine+blood -0.52481203 0 0 yes serum_phospholipids serum_aminoacids 0.262 0.0107 no no no no up no 16:0/18:1-PC+blood L-Lysine+blood 0 0 0.411965812 yes serum_phospholipids serum_aminoacids 6.15E-07 0.0107 up up up no up no 16:0/18:2-PC+blood L-Lysine+blood 0 0.524509804 0.554871795 yes serum_phospholipids serum_aminoacids 3.24E-06 0.0107 no up up no up no 16:0/20:3-PC+blood L-Lysine+blood 0 0.495098039 0 yes serum_phospholipids serum_aminoacids 5.43E-06 0.0107 no up up no up no 16:0/20:5-PC+blood L-Lysine+blood 0 -0.495098039 0 yes serum_phospholipids serum_aminoacids 0.628 0.0107 no no no no up no 16:0/22:6-PC+blood L-Lysine+blood 0.455639098 0 0.447521368 yes serum_phospholipids serum_aminoacids 4.53E-05 0.0107 no up up no up no 16:1/16:0-PC+blood L-Lysine+blood 0 0 0.488547009 yes serum_phospholipids serum_aminoacids 0.0215 0.0107 no up up no up no 18:0/16:0-PC+blood L-Lysine+blood 0 0 0.401025641 yes serum_phospholipids serum_aminoacids 9.64E-07 0.0107 up up up no up no 18:0/18:0-PE+blood L-Lysine+blood 0 0 -0.410598291 yes serum_phospholipids serum_aminoacids 0.00896 0.0107 up up no no up no 18:0/18:2-PC+blood L-Lysine+blood 0 0 0.499487179 yes serum_phospholipids serum_aminoacids 1.74E-06 0.0107 no up up no up no 18:0/20:5-PC+blood L-Lysine+blood 0.484210526 0 0 yes serum_phospholipids serum_aminoacids 0.17 0.0107 no no no no up no 18:0/22:6-PC+blood L-Lysine+blood 0 0 0.455726496 yes serum_phospholipids serum_aminoacids 0.0775 0.0107 no no up no up no 18:0+blood L-Lysine+blood 0 0 0.534358974 yes serum_fattyacid serum_aminoacids 0.344 0.0107 no no no no up no 18:1/16:0-PC+blood L-Lysine+blood 0 0.509803922 0.548717949 yes serum_phospholipids serum_aminoacids 2.43E-05 0.0107 no up up no up no 18:1/18:0-PC+blood L-Lysine+blood 0 0 0.478290598 yes serum_phospholipids serum_aminoacids 1.83E-06 0.0107 no up up no up no 18:1/18:2-PE+blood L-Lysine+blood 0 0 -0.503589744 yes serum_phospholipids serum_aminoacids 0.000293 0.0107 up up no no up no 18:1/20:4-PE+blood L-Lysine+blood 0 -0.612745098 0 yes serum_phospholipids serum_aminoacids 0.0578 0.0107 up no no no up no 18:2/18:2-PS+blood L-Lysine+blood -0.502255639 0 0 yes serum_phospholipids serum_aminoacids 0.00674 0.0107 up up no no up no 18:3/16:0-PE+blood L-Lysine+blood -0.497744361 -0.504901961 0 yes serum_phospholipids serum_aminoacids 0.00149 0.0107 up up no no up no 18:3/18:2-PC+blood L-Lysine+blood 0 0 -0.497435897 yes serum_phospholipids serum_aminoacids 0.0394 0.0107 no no up no up no 18:3n6+blood L-Lysine+blood -0.631578947 0 0 yes serum_fattyacid serum_aminoacids 0.0463 0.0107 up no dn no up no 20:1/20:4-PC+blood L-Lysine+blood 0 0 0.503589744 yes serum_phospholipids serum_aminoacids 0.0419 0.0107 no no up no up no 20:1/20:4-PE+blood L-Lysine+blood 0 -0.504901961 0 yes serum_phospholipids serum_aminoacids 0.0042 0.0107 up up no no up no 20:3/16:0-PC+blood L-Lysine+blood 0 0 0.403076923 yes serum_phospholipids serum_aminoacids 0.00405 0.0107 no up up no up no 20:4/16:0-PE+blood L-Lysine+blood 0 0 -0.514529915 yes serum_phospholipids serum_aminoacids 0.00529 0.0107 no up up no up no 20:4/18:0-PE+blood L-Lysine+blood 0 -0.490196078 0 yes serum_phospholipids serum_aminoacids 0.000755 0.0107 up up no no up no 22:1-LPA+blood L-Lysine+blood 0 0.485294118 0 yes serum_phospholipids serum_aminoacids 0.00373 0.0107 no up up no up no Acute myeloid leukemia L-Lysine+blood 0.547368421 0 0 yes kegg serum_aminoacids NA 0.0107 no no no no up no Adherens junction L-Lysine+blood 0 0 -0.484615385 yes kegg serum_aminoacids NA 0.0107 no no no no up no AGE-RAGE signaling pathway in diabetic complications L-Lysine+blood 0.480701754 0 0 yes kegg serum_aminoacids NA 0.0107 no no no no up no Alzheimer disease L-Lysine+blood 0 0 -0.593076923 yes kegg serum_aminoacids NA 0.0107 no no no no up no Amyotrophic lateral sclerosis L-Lysine+blood 0 0 -0.576923077 yes kegg serum_aminoacids NA 0.0107 no no no no up no Arginine and proline metabolism L-Lysine+blood 0 0 0.45 yes kegg serum_aminoacids NA 0.0107 no up no no up no Arrhythmogenic right ventricular cardiomyopathy L-Lysine+blood 0 0 -0.523076923 yes kegg serum_aminoacids NA 0.0107 no up up no up no Bacterial invasion of epithelial cells L-Lysine+blood 0 0 -0.448461538 yes kegg serum_aminoacids NA 0.0107 no no no no up no Blautia L-Lysine+blood 0 0.526960784 0 acetate-producing yes Genus serum_aminoacids 1.36E-05 0.0107 up dn dn no up no Butyricimonas L-Lysine+blood 0 0 0.500284241 butyrate-producing yes Genus serum_aminoacids 0.17 0.0107 no no no no up no CA+stool L-Lysine+blood 0 0 -0.497744361 yes stool_bileacids serum_aminoacids 0.827 0.0107 no no no no up no Cardiac muscle contraction L-Lysine+blood 0 0 -0.641538462 yes kegg serum_aminoacids NA 0.0107 no no up no up no CDCA+stool L-Lysine+blood 0 0 -0.448120301 yes stool_bileacids serum_aminoacids 0.663 0.0107 no no no no up no Cell adhesion molecules L-Lysine+blood 0 0 -0.418461538 yes kegg serum_aminoacids NA 0.0107 no no no no up no Cell cycle L-Lysine+blood -0.484210526 0 0 yes kegg serum_aminoacids NA 0.0107 no no no no up no Choline+blood L-Lysine+blood 0.490225564 0 0 yes serum_choline serum_aminoacids 0.0395 0.0107 no up no no up no Creatinine+blood L-Lysine+blood 0.796992481 0 0 yes serum_choline serum_aminoacids 0.437 0.0107 no no no no up no Cysteine+blood L-Lysine+blood 0.458646617 0 0.561709402 yes yes serum_aminoacids serum_aminoacids 1.81E-07 0.0107 dn up up no up no Cystine+blood L-Lysine+blood 0.667669173 0.742647059 0.486495726 yes yes serum_aminoacids serum_aminoacids 0.00028 0.0107 up up no no up no Cytokine-cytokine receptor interaction L-Lysine+blood 0 0 -0.445384615 yes kegg serum_aminoacids NA 0.0107 no no no no up no d18:0-18:3-SM+blood L-Lysine+blood 0 0 -0.401025641 yes serum_phospholipids serum_aminoacids 0.0879 0.0107 no dn no no up no d18:1-14:0-SM+blood L-Lysine+blood 0 0 -0.419487179 yes serum_phospholipids serum_aminoacids 0.94 0.0107 no no no no up no d18:1-14:1-SM+blood L-Lysine+blood -0.57443609 -0.50245098 -0.422905983 yes serum_phospholipids serum_aminoacids 0.0952 0.0107 no dn no no up no d18:1-16:1-SM+blood L-Lysine+blood 0 0 -0.459145299 yes serum_phospholipids serum_aminoacids 0.2 0.0107 no no no no up no Diabetic cardiomyopathy L-Lysine+blood 0 0 -0.580769231 yes kegg serum_aminoacids NA 0.0107 no no no no up no Dilated cardiomyopathy L-Lysine+blood 0 0 -0.605384615 yes kegg serum_aminoacids NA 0.0107 no up up no up no DL-methionine sulfoxide+blood L-Lysine+blood 0 0.541666667 0 yes serum_aminoacids serum_aminoacids 0.302 0.0107 no no no no up no DMG+blood L-Lysine+blood 0 0 0.433846154 yes serum_choline serum_aminoacids 0.909 0.0107 no no no no up no Estrogen signaling pathway L-Lysine+blood 0 0 -0.511538462 yes kegg serum_aminoacids NA 0.0107 no no no no up no Ethanolamine+blood L-Lysine+blood 0.479699248 0.558823529 0.518632479 yes serum_aminoacids serum_aminoacids 0.122 0.0107 up no no no up no Fc epsilon RI signaling pathway L-Lysine+blood 0.642105263 0 0 yes kegg serum_aminoacids NA 0.0107 no no no no up no Focal adhesion L-Lysine+blood 0 0 -0.601538462 yes kegg serum_aminoacids NA 0.0107 no up up no up no Gastric acid secretion L-Lysine+blood 0 0 -0.521538462 yes kegg serum_aminoacids NA 0.0107 no no no no up no GDCA+stool L-Lysine+blood 0 0.838270968 0 yes stool_bileacids serum_aminoacids 0.656 0.0107 no no no no up no "Glycine, serine and threonine metabolism" L-Lysine+blood -0.487719298 0 0 yes kegg serum_aminoacids NA 0.0107 no up no no up no GPC+blood L-Lysine+blood 0 0.487745098 0 yes serum_choline serum_aminoacids 0.00427 0.0107 no up up no up no Hippo signaling pathway L-Lysine+blood 0 0 -0.625384615 yes kegg serum_aminoacids NA 0.0107 no no no no up no Huntington disease L-Lysine+blood 0 0 -0.542307692 yes kegg serum_aminoacids NA 0.0107 no no no no up no Hypertrophic cardiomyopathy L-Lysine+blood 0 0 -0.506153846 yes kegg serum_aminoacids NA 0.0107 no up up no up no Influenza A L-Lysine+blood 0.514035088 0 0 yes kegg serum_aminoacids NA 0.0107 no no no no up no iso-DCA+blood L-Lysine+blood 0 0 0.466666667 yes serum_bileacids serum_aminoacids 0.38 0.0107 no no no no up no L-2-Aminobutyric acid+blood L-Lysine+blood 0.566917293 0 0.442735043 yes yes serum_aminoacids serum_aminoacids 0.000328 0.0107 up up no no up no L-Alanine+blood L-Lysine+blood 0.523308271 0.492647059 0 yes yes serum_aminoacids serum_aminoacids 0.00138 0.0107 up up no no up no L-Arginine+blood L-Lysine+blood 0.538345865 0.595588235 0.539145299 yes serum_aminoacids serum_aminoacids 0.316 0.0107 no no no no up no L-Asparagine+blood L-Lysine+blood 0.593984962 0.615196078 0 yes serum_aminoacids serum_aminoacids 0.784 0.0107 no no no no up no L-Aspartic acid+blood L-Lysine+blood 0 0 0.507692308 yes yes serum_aminoacids serum_aminoacids 0.0226 0.0107 up up no no up no L-Glutamic acid+blood L-Lysine+blood 0.70075188 0.705882353 0.582222222 yes yes serum_aminoacids serum_aminoacids 6.20E-05 0.0107 up up no no up no L-Glutamine+blood L-Lysine+blood 0.577443609 0.593137255 0 yes serum_aminoacids serum_aminoacids 0.639 0.0107 no no no no up no L-Histidine+blood L-Lysine+blood 0.609022556 0.620098039 0.591111111 yes serum_aminoacids serum_aminoacids 0.109 0.0107 no no no no up no L-Isoleucine+blood L-Lysine+blood 0.636090226 0.74754902 0.56991453 yes yes serum_aminoacids serum_aminoacids 5.47E-06 0.0107 up up no no up no L-Leucine+blood L-Lysine+blood 0 0.519607843 0 yes yes serum_aminoacids serum_aminoacids 3.22E-05 0.0107 up up no no up no L-Tryptophan+stool L-Lysine+blood 0 0 0.44962406 yes stool_cometabolism serum_aminoacids 0.557 0.0107 no no no no up no L-Tyrosine+stool L-Lysine+blood 0 0 0.464661654 yes stool_cometabolism serum_aminoacids 0.44 0.0107 no no no no up no Legionellosis L-Lysine+blood -0.594736842 0 0 yes kegg serum_aminoacids NA 0.0107 no no no no up no Leishmaniasis L-Lysine+blood -0.535087719 0 0 yes kegg serum_aminoacids NA 0.0107 no no no no up no Leukocyte transendothelial migration L-Lysine+blood 0 0 -0.403846154 yes kegg serum_aminoacids NA 0.0107 no no no no up no Non-alcoholic fatty liver disease L-Lysine+blood 0 0 -0.585384615 yes kegg serum_aminoacids NA 0.0107 no no no no up no Oxidative phosphorylation L-Lysine+blood 0 0 -0.586923077 yes kegg serum_aminoacids NA 0.0107 no no no no up no Phospholipase D signaling pathway L-Lysine+blood 0.643859649 0 0 yes kegg serum_aminoacids NA 0.0107 no up up no up no Platelet activation L-Lysine+blood 0 0 -0.476923077 yes kegg serum_aminoacids NA 0.0107 no no no no up no Prion disease L-Lysine+blood 0 0 -0.679230769 yes kegg serum_aminoacids NA 0.0107 no no no no up no Prolactin signaling pathway L-Lysine+blood 0.510526316 0 0 yes kegg serum_aminoacids NA 0.0107 no no no no up no Purine metabolism L-Lysine+blood 0 0 0.438461538 yes kegg serum_aminoacids NA 0.0107 no no no no up no Regulation of actin cytoskeleton L-Lysine+blood 0 0 -0.473076923 yes kegg serum_aminoacids NA 0.0107 no no no no up no Retrograde endocannabinoid signaling L-Lysine+blood 0 0 -0.506923077 yes kegg serum_aminoacids NA 0.0107 no no up no up no RNA transport L-Lysine+blood -0.594736842 0 0 yes kegg serum_aminoacids NA 0.0107 no no no no up no Thermogenesis L-Lysine+blood 0 0 -0.533846154 yes kegg serum_aminoacids NA 0.0107 no no no no up no Thyroid hormone signaling pathway L-Lysine+blood 0 0 -0.512307692 yes kegg serum_aminoacids NA 0.0107 no no no no up no Viral protein interaction with cytokine and cytokine receptor L-Lysine+blood 0 0 -0.508461538 yes kegg serum_aminoacids NA 0.0107 no no no no up no 12-HEPE+blood L-Methionine+blood 0.575704432 -0.576306805 0 serum_ARA serum_aminoacids 0.312 0.626 no no no no no no 13-HODE+blood L-Methionine+blood 0.472180451 0 0 serum_ARA serum_aminoacids 0.32 0.626 no no no no no no 14:0/20:4-PC+blood L-Methionine+blood -0.446616541 0 -0.425641026 serum_phospholipids serum_aminoacids 0.486 0.626 no no no no no no 16:0/18:0-PS+blood L-Methionine+blood -0.554887218 -0.512254902 0 serum_phospholipids serum_aminoacids 0.377 0.626 no no no no no no 16:0/18:1-PE+blood L-Methionine+blood -0.557894737 0 0 serum_phospholipids serum_aminoacids 0.000107 0.626 up up no no no no 16:0/18:2-PC+blood L-Methionine+blood 0.467669173 0 0 serum_phospholipids serum_aminoacids 3.24E-06 0.626 no up up no no no 16:0/20:3-PC+blood L-Methionine+blood 0.476691729 0 0 serum_phospholipids serum_aminoacids 5.43E-06 0.626 no up up no no no 16:0/20:5-PC+blood L-Methionine+blood 0 -0.583333333 0 serum_phospholipids serum_aminoacids 0.628 0.626 no no no no no no 16:0/22:6-PE+blood L-Methionine+blood -0.52481203 -0.522058824 0 serum_phospholipids serum_aminoacids 0.000934 0.626 up up no no no no 16:1/18:2-PG+blood L-Methionine+blood 0.457142857 0 0 serum_phospholipids serum_aminoacids 1.40E-08 0.626 no up up no no no 18:0-LPA+blood L-Methionine+blood 0 0.536764706 0 serum_phospholipids serum_aminoacids 0.0725 0.626 no dn no no no no 18:0/16:0-PC+blood L-Methionine+blood 0 0 0.402393162 serum_phospholipids serum_aminoacids 9.64E-07 0.626 up up up no no no 18:0/18:0-PE+blood L-Methionine+blood -0.631578947 0 0 serum_phospholipids serum_aminoacids 0.00896 0.626 up up no no no no 18:0/18:0-PS+blood L-Methionine+blood -0.505263158 0 0 serum_phospholipids serum_aminoacids 0.00617 0.626 no up no no no no 18:0/18:1-PE+blood L-Methionine+blood -0.62406015 0 0 serum_phospholipids serum_aminoacids 0.00716 0.626 up up no no no no 18:0/18:2-PC+blood L-Methionine+blood 0.452631579 0 0 serum_phospholipids serum_aminoacids 1.74E-06 0.626 no up up no no no 18:0/20:3-PI+blood L-Methionine+blood 0.593984962 0 0 serum_phospholipids serum_aminoacids 0.377 0.626 no no no no no no 18:1/16:0-PE+blood L-Methionine+blood -0.660150376 0 0 serum_phospholipids serum_aminoacids 0.000182 0.626 up up no no no no 18:1/16:1-PE+blood L-Methionine+blood -0.586466165 0 0 serum_phospholipids serum_aminoacids 0.000184 0.626 up up no no no no 18:1/18:0-PS+blood L-Methionine+blood 0 -0.551470588 0 serum_phospholipids serum_aminoacids 0.193 0.626 no no no no no no 18:1/18:1-PE+blood L-Methionine+blood -0.521804511 0 0 serum_phospholipids serum_aminoacids 1.03E-05 0.626 up up no no no no 18:1/18:2-PE+blood L-Methionine+blood -0.464661654 0 0 serum_phospholipids serum_aminoacids 0.000293 0.626 up up no no no no 18:2-LPA+blood L-Methionine+blood 0 0.544117647 0 serum_phospholipids serum_aminoacids 0.00684 0.626 dn no up no no no 18:2/18:2-PS+blood L-Methionine+blood -0.50075188 0 0 serum_phospholipids serum_aminoacids 0.00674 0.626 up up no no no no 18:3/16:0-PE+blood L-Methionine+blood -0.714285714 0 0 serum_phospholipids serum_aminoacids 0.00149 0.626 up up no no no no 18:3n6+blood L-Methionine+blood -0.583458647 0 -0.425641026 serum_fattyacid serum_aminoacids 0.0463 0.626 up no dn no no no 20:0+blood L-Methionine+blood 0 -0.487745098 0 yes serum_fattyacid serum_aminoacids 0.000278 0.626 dn no up no no no 20:1-LPA+blood L-Methionine+blood 0 0.531862745 0 serum_phospholipids serum_aminoacids 0.0187 0.626 dn dn no no no no 20:1-LPE+blood L-Methionine+blood 0 -0.526960784 0 serum_phospholipids serum_aminoacids 0.465 0.626 no no no no no no 20:2-LPC+blood L-Methionine+blood 0.6 0 0 serum_phospholipids serum_aminoacids 0.119 0.626 no no up no no no 20:2-LPE+blood L-Methionine+blood 0 -0.598039216 0 serum_phospholipids serum_aminoacids 0.177 0.626 no no no no no no 20:2/18:1-PE+blood L-Methionine+blood -0.584962406 0 0 serum_phospholipids serum_aminoacids 0.00208 0.626 up up no no no no 20:4-LPA+blood L-Methionine+blood 0 0.509803922 0 serum_phospholipids serum_aminoacids 0.398 0.626 no no no no no no 20:4-LPE+blood L-Methionine+blood 0 0 -0.40034188 serum_phospholipids serum_aminoacids 0.552 0.626 no no no no no no 20:5n3+blood L-Methionine+blood 0 -0.56127451 0 serum_fattyacid serum_aminoacids 0.988 0.626 no no no no no no 22:1-LPA+blood L-Methionine+blood 0 0.617647059 0 serum_phospholipids serum_aminoacids 0.00373 0.626 no up up no no no Adrenergic signaling in cardiomyocytes L-Methionine+blood 0.614035088 0 0 kegg serum_aminoacids NA 0.626 no no up no no no AGE-RAGE signaling pathway in diabetic complications L-Methionine+blood 0.60877193 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Autophagy - animal L-Methionine+blood 0 0 0.443076923 kegg serum_aminoacids NA 0.626 no no no no no no Biosynthesis of amino acids L-Methionine+blood -0.584210526 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Blautia L-Methionine+blood 0 0.512254902 0 acetate-producing Genus serum_aminoacids 1.36E-05 0.626 up dn dn no no no Breast cancer L-Methionine+blood 0.49122807 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Butyricimonas L-Methionine+blood 0.485584373 -0.594283918 0 butyrate-producing Genus serum_aminoacids 0.17 0.626 no no no no no no Calcium signaling pathway L-Methionine+blood 0.564912281 0 0 kegg serum_aminoacids NA 0.626 no up up no no no cAMP signaling pathway L-Methionine+blood 0.561403509 0 0 yes kegg serum_aminoacids NA 0.626 no up up no no no Carbon metabolism L-Methionine+blood -0.661403509 0 0 kegg serum_aminoacids NA 0.626 no no no no no no CDCA+blood L-Methionine+blood 0 0 -0.408547009 serum_bileacids serum_aminoacids 0.506 0.626 no no no no no no cGMP-PKG signaling pathway L-Methionine+blood 0.477192982 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Choline metabolism in cancer L-Methionine+blood 0.519298246 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Choline+blood L-Methionine+blood 0.460150376 0 0 serum_choline serum_aminoacids 0.0395 0.626 no up no no no no Clostridium L-Methionine+blood 0 0.501532896 0 Genus serum_aminoacids 0.925 0.626 no no no no no no Colorectal cancer L-Methionine+blood 0.505263158 -0.576470588 0 kegg serum_aminoacids NA 0.626 no no no no no no Creatinine+blood L-Methionine+blood 0.666165414 0.620098039 0 serum_choline serum_aminoacids 0.437 0.626 no no no no no no Cysteine+blood L-Methionine+blood 0.476691729 0 0.44957265 yes serum_aminoacids serum_aminoacids 1.81E-07 0.626 dn up up no no no Cystine+blood L-Methionine+blood 0 0.566176471 0 yes serum_aminoacids serum_aminoacids 0.00028 0.626 up up no no no no Cytokine-cytokine receptor interaction L-Methionine+blood 0 0 -0.418461538 kegg serum_aminoacids NA 0.626 no no no no no no d18:0-18:3-SM+blood L-Methionine+blood 0 0 -0.573333333 serum_phospholipids serum_aminoacids 0.0879 0.626 no dn no no no no d18:1-14:0-SM+blood L-Methionine+blood -0.445112782 0 0 serum_phospholipids serum_aminoacids 0.94 0.626 no no no no no no d18:1-14:1-SM+blood L-Methionine+blood -0.514285714 0 -0.55008547 serum_phospholipids serum_aminoacids 0.0952 0.626 no dn no no no no d18:1-16:1-SM+blood L-Methionine+blood 0 0 -0.497435897 serum_phospholipids serum_aminoacids 0.2 0.626 no no no no no no d18:1-20:0-SM+blood L-Methionine+blood -0.497744361 0 0 serum_phospholipids serum_aminoacids 0.933 0.626 no no no no no no decanoic acid C10+blood L-Methionine+blood 0.494736842 0 0 serum_mcfa serum_aminoacids 6.64E-11 0.626 dn dn no no no no DL-methionine sulfoxide+blood L-Methionine+blood 0 0.490196078 0.445470085 serum_aminoacids serum_aminoacids 0.302 0.626 no no no no no no DMG+blood L-Methionine+blood 0 0.590686275 0.447521368 serum_choline serum_aminoacids 0.909 0.626 no no no no no no Dopaminergic synapse L-Methionine+blood 0.459649123 0 0 kegg serum_aminoacids NA 0.626 no up no no no no ErbB signaling pathway L-Methionine+blood 0.559649123 -0.547058824 0 kegg serum_aminoacids NA 0.626 no no no no no no Ethanolamine+blood L-Methionine+blood 0 0 0.556923077 serum_aminoacids serum_aminoacids 0.122 0.626 up no no no no no Fc epsilon RI signaling pathway L-Methionine+blood 0.635087719 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Gap junction L-Methionine+blood 0 0 -0.446923077 kegg serum_aminoacids NA 0.626 no no no no no no Gastric cancer L-Methionine+blood 0 -0.538235294 0 kegg serum_aminoacids NA 0.626 no no no no no no GCA+stool L-Methionine+blood -0.593406593 0 0 stool_bileacids serum_aminoacids 0.0809 0.626 no no no no no no GDCA+stool L-Methionine+blood 0 0.656038149 0 stool_bileacids serum_aminoacids 0.656 0.626 no no no no no no Glioma L-Methionine+blood 0.571929825 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Glycolysis / Gluconeogenesis L-Methionine+blood -0.659649123 0 0 kegg serum_aminoacids NA 0.626 no no no no no no GPC+blood L-Methionine+blood 0 0.485294118 0 serum_choline serum_aminoacids 0.00427 0.626 no up up no no no "Growth hormone synthesis, secretion and action" L-Methionine+blood 0.531578947 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Hypotaurine+blood L-Methionine+blood 0 0 0.638974359 serum_aminoacids serum_aminoacids 0.933 0.626 no no no no no no Inflammatory mediator regulation of TRP channels L-Methionine+blood 0.457894737 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Intestinal immune network for IgA production L-Methionine+blood 0.457894737 0 0 kegg serum_aminoacids NA 0.626 no no no no no no iso-heptanoic acid C7+blood L-Methionine+blood -0.464661654 0 0 serum_mcfa serum_aminoacids 0.00256 0.626 up up no no no no L-2-Aminobutyric acid+blood L-Methionine+blood 0.484210526 0 0 yes serum_aminoacids serum_aminoacids 0.000328 0.626 up up no no no no L-Alanine+blood L-Methionine+blood 0 0.718137255 0 yes serum_aminoacids serum_aminoacids 0.00138 0.626 up up no no no no L-Arginine+blood L-Methionine+blood 0.627067669 0.578431373 0 serum_aminoacids serum_aminoacids 0.316 0.626 no no no no no no L-Asparagine+blood L-Methionine+blood 0 0.737745098 0.626666667 serum_aminoacids serum_aminoacids 0.784 0.626 no no no no no no L-Citrulline+blood L-Methionine+blood 0.49924812 0 0.446153846 serum_aminoacids serum_aminoacids 0.534 0.626 no no no no no no L-Glutamic acid+blood L-Methionine+blood 0 0.549019608 0 yes serum_aminoacids serum_aminoacids 6.20E-05 0.626 up up no no no no L-Glutamine+blood L-Methionine+blood 0 0.512254902 0 serum_aminoacids serum_aminoacids 0.639 0.626 no no no no no no L-Histidine+blood L-Methionine+blood 0.566917293 0.539215686 0.472136752 serum_aminoacids serum_aminoacids 0.109 0.626 no no no no no no L-Homocystine+blood L-Methionine+blood 0.469172932 0 0 serum_aminoacids serum_aminoacids 0.197 0.626 no no no no no no L-Isoleucine+blood L-Methionine+blood 0 0.774509804 0.552820513 yes serum_aminoacids serum_aminoacids 5.47E-06 0.626 up up no no no no L-Leucine+blood L-Methionine+blood 0 0.727941176 0.409230769 yes serum_aminoacids serum_aminoacids 3.22E-05 0.626 up up no no no no L-Lysine+blood L-Methionine+blood 0.64962406 0.737745098 0 yes serum_aminoacids serum_aminoacids 0.0107 0.626 no up no no no no L-Phenylalanine+stool L-Methionine+blood 0 0 0.464661654 stool_cometabolism serum_aminoacids 0.398 0.626 no no no no no no L-Tyrosine+stool L-Methionine+blood 0 0 0.481203008 stool_cometabolism serum_aminoacids 0.44 0.626 no no no no no no Lachnospira L-Methionine+blood 0 0.543225117 0 butyrate-producing Genus serum_aminoacids 0.279 0.626 no no no no no no Legionellosis L-Methionine+blood -0.564912281 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Leishmaniasis L-Methionine+blood -0.645614035 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Long-term depression L-Methionine+blood 0 0 -0.460769231 kegg serum_aminoacids NA 0.626 no no no no no no mRNA surveillance pathway L-Methionine+blood 0.515789474 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Non-alcoholic fatty liver disease L-Methionine+blood 0.468421053 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Non-small cell lung cancer L-Methionine+blood 0.464912281 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Oxytocin signaling pathway L-Methionine+blood 0 0 -0.406923077 kegg serum_aminoacids NA 0.626 no no no no no no Pancreatic cancer L-Methionine+blood 0.5 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Pathways in cancer L-Methionine+blood 0.607017544 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Phosphatidylinositol signaling system L-Methionine+blood 0.528070175 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Phospholipase D signaling pathway L-Methionine+blood 0.612280702 0 0 kegg serum_aminoacids NA 0.626 no up up no no no Progesterone-mediated oocyte maturation L-Methionine+blood 0 0 0.437692308 kegg serum_aminoacids NA 0.626 no no no no no no Prolactin signaling pathway L-Methionine+blood 0.610526316 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Renal cell carcinoma L-Methionine+blood 0.478947368 0 0 kegg serum_aminoacids NA 0.626 no no no no no no RNA degradation L-Methionine+blood 0.480701754 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Signaling pathways regulating pluripotency of stem cells L-Methionine+blood 0.568421053 -0.532352941 0 kegg serum_aminoacids NA 0.626 no no no no no no Sphingolipid signaling pathway L-Methionine+blood 0.622807018 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Spinocerebellar ataxia L-Methionine+blood 0 0 0.426153846 kegg serum_aminoacids NA 0.626 no no no no no no VEGF signaling pathway L-Methionine+blood 0.61754386 0 0 kegg serum_aminoacids NA 0.626 no no no no no no Vibrio cholerae infection L-Methionine+blood 0 0 -0.404615385 kegg serum_aminoacids NA 0.626 no no no no no no 13-HODE+blood L-Ornithine+blood 0 0.534313725 0.421538462 serum_ARA serum_aminoacids 0.32 0.175 no no no no no no 14:0/18:0-PC+blood L-Ornithine+blood 0 0 -0.451623932 serum_phospholipids serum_aminoacids 0.00289 0.175 up up no no no no 14:0/18:2-PC+blood L-Ornithine+blood -0.634586466 -0.568627451 0 serum_phospholipids serum_aminoacids 0.102 0.175 no up no no no no 14:0/20:4-PC+blood L-Ornithine+blood -0.75037594 -0.556372549 -0.422222222 serum_phospholipids serum_aminoacids 0.486 0.175 no no no no no no 14:0+blood L-Ornithine+blood -0.454135338 0 0 yes serum_fattyacid serum_aminoacids 0.00572 0.175 up no dn no no no 16:0-LPE+blood L-Ornithine+blood 0 0.534313725 -0.580854701 serum_phospholipids serum_aminoacids 0.0711 0.175 up up no no no no 16:0/16:1-PC+blood L-Ornithine+blood 0 0 -0.495384615 serum_phospholipids serum_aminoacids 0.00283 0.175 up up no no no no 16:0/18:0-PC+blood L-Ornithine+blood 0 -0.598039216 0 serum_phospholipids serum_aminoacids 0.521 0.175 no no no no no no 16:0/18:0-PS+blood L-Ornithine+blood 0 0 -0.44957265 serum_phospholipids serum_aminoacids 0.377 0.175 no no no no no no 16:0/18:1-PE+blood L-Ornithine+blood 0 0 -0.40991453 serum_phospholipids serum_aminoacids 0.000107 0.175 up up no no no no 16:0/18:3-PC+blood L-Ornithine+blood 0 -0.580882353 -0.445470085 serum_phospholipids serum_aminoacids 0.00216 0.175 no up up no no no 16:0/20:5-PC+blood L-Ornithine+blood 0 -0.487745098 0 serum_phospholipids serum_aminoacids 0.628 0.175 no no no no no no 16:0/22:6-PE+blood L-Ornithine+blood 0 0 -0.50017094 serum_phospholipids serum_aminoacids 0.000934 0.175 up up no no no no 18:0-LPE+blood L-Ornithine+blood 0 0 -0.472136752 serum_phospholipids serum_aminoacids 0.491 0.175 no no no no no no 18:0/18:0-PS+blood L-Ornithine+blood 0 -0.517156863 0 serum_phospholipids serum_aminoacids 0.00617 0.175 no up no no no no 18:0/20:3-PC+blood L-Ornithine+blood -0.491729323 0 0 serum_phospholipids serum_aminoacids 0.0682 0.175 no up no no no no 18:0/22:6-PC+blood L-Ornithine+blood 0 0 0.458461538 serum_phospholipids serum_aminoacids 0.0775 0.175 no no up no no no 18:1-LPE+blood L-Ornithine+blood 0 0.68627451 0 serum_phospholipids serum_aminoacids 0.117 0.175 no no no no no no 18:1/18:0-PE+blood L-Ornithine+blood 0 0 -0.44957265 serum_phospholipids serum_aminoacids 1.39E-06 0.175 up up no no no no 18:1/18:1-PE+blood L-Ornithine+blood 0 0 -0.526837607 serum_phospholipids serum_aminoacids 1.03E-05 0.175 up up no no no no 18:1/18:2-PE+blood L-Ornithine+blood 0 0 -0.469401709 serum_phospholipids serum_aminoacids 0.000293 0.175 up up no no no no 18:1/18:2-PI+blood L-Ornithine+blood 0 0.600490196 0 serum_phospholipids serum_aminoacids 0.0164 0.175 dn no up no no no 18:3/16:0-PE+blood L-Ornithine+blood 0 0 -0.457094017 serum_phospholipids serum_aminoacids 0.00149 0.175 up up no no no no 18:3/18:2-PC+blood L-Ornithine+blood -0.469172932 0 0 serum_phospholipids serum_aminoacids 0.0394 0.175 no no up no no no 20:0/20:4-PE+blood L-Ornithine+blood 0 0 -0.469401709 serum_phospholipids serum_aminoacids 0.00128 0.175 up up no no no no 20:1/20:4-PC+blood L-Ornithine+blood 0 0 0.47965812 serum_phospholipids serum_aminoacids 0.0419 0.175 no no up no no no 20:1/20:4-PE+blood L-Ornithine+blood 0 0 -0.459145299 serum_phospholipids serum_aminoacids 0.0042 0.175 up up no no no no 20:2/18:0-PC+blood L-Ornithine+blood -0.559398496 0 0 serum_phospholipids serum_aminoacids 0.0427 0.175 no up no no no no 20:2/18:1-PE+blood L-Ornithine+blood 0 0 -0.621880342 serum_phospholipids serum_aminoacids 0.00208 0.175 up up no no no no 20:3-LPE+blood L-Ornithine+blood 0 0 -0.407179487 serum_phospholipids serum_aminoacids 0.084 0.175 no up no no no no 20:4/18:0-PE+blood L-Ornithine+blood 0 0 -0.436581197 serum_phospholipids serum_aminoacids 0.000755 0.175 up up no no no no 22:6-LPC+blood L-Ornithine+blood 0 0 0.419487179 serum_phospholipids serum_aminoacids 0.127 0.175 no no up no no no 3-(3-Hydroxyphenyl)propanoic acid+stool L-Ornithine+blood -0.67032967 0 0 stool_cometabolism serum_aminoacids 0.33 0.175 no no no no no no 8-HETE+blood L-Ornithine+blood 0 0.5 0 serum_ARA serum_aminoacids 0.741 0.175 no no no no no no 9-HODE+blood L-Ornithine+blood -0.484210526 0 0 serum_ARA serum_aminoacids 0.297 0.175 no no no no no no Adherens junction L-Ornithine+blood 0 -0.520588235 0 kegg serum_aminoacids NA 0.175 no no no no no no Adipocytokine signaling pathway L-Ornithine+blood 0.557894737 0.517647059 0 kegg serum_aminoacids NA 0.175 no no no no no no Allograft rejection L-Ornithine+blood 0 0 -0.528461538 kegg serum_aminoacids NA 0.175 no no no no no no Alzheimer disease L-Ornithine+blood 0 0 -0.467692308 kegg serum_aminoacids NA 0.175 no no no no no no Amyotrophic lateral sclerosis L-Ornithine+blood 0 0 -0.412307692 kegg serum_aminoacids NA 0.175 no no no no no no Antigen processing and presentation L-Ornithine+blood 0 0 -0.435384615 kegg serum_aminoacids NA 0.175 no no no no no no Arrhythmogenic right ventricular cardiomyopathy L-Ornithine+blood 0 -0.582352941 0 kegg serum_aminoacids NA 0.175 no up up no no no Asthma L-Ornithine+blood 0 -0.635294118 0 kegg serum_aminoacids NA 0.175 no no no no no no Autoimmune thyroid disease L-Ornithine+blood 0 0 -0.528461538 kegg serum_aminoacids NA 0.175 no no no no no no Bacterial invasion of epithelial cells L-Ornithine+blood 0 -0.505882353 0 kegg serum_aminoacids NA 0.175 no no no no no no Betaine+blood L-Ornithine+blood 0 0 0.474871795 serum_choline serum_aminoacids 0.857 0.175 no no no no no no Bifidobacterium L-Ornithine+blood -0.594208391 0 0 acetate-producing Genus serum_aminoacids 0.105 0.175 no dn no no no no Blautia L-Ornithine+blood 0 0 -0.461409233 acetate-producing Genus serum_aminoacids 1.36E-05 0.175 up dn dn no no no butyric acid C4+blood L-Ornithine+blood 0 0.593137255 0 serum_scfa serum_aminoacids 0.407 0.175 no no no no no no CA+stool L-Ornithine+blood 0 0 -0.544360902 stool_bileacids serum_aminoacids 0.827 0.175 no no no no no no Carbon metabolism L-Ornithine+blood 0 -0.611764706 0 kegg serum_aminoacids NA 0.175 no no no no no no Cardiac muscle contraction L-Ornithine+blood 0 0 -0.436153846 kegg serum_aminoacids NA 0.175 no no up no no no CDCA+stool L-Ornithine+blood 0 0 -0.493233083 stool_bileacids serum_aminoacids 0.663 0.175 no no no no no no Cell adhesion molecules L-Ornithine+blood 0 0 -0.5 kegg serum_aminoacids NA 0.175 no no no no no no Cell cycle L-Ornithine+blood -0.563157895 0 0 kegg serum_aminoacids NA 0.175 no no no no no no Cellular senescence L-Ornithine+blood 0 0 -0.429230769 kegg serum_aminoacids NA 0.175 no no no no no no Central carbon metabolism in cancer L-Ornithine+blood -0.485964912 0 0 kegg serum_aminoacids NA 0.175 no no no no no no Cystine+blood L-Ornithine+blood 0.609022556 0 0 yes serum_aminoacids serum_aminoacids 0.00028 0.175 up up no no no no Cytosolic DNA-sensing pathway L-Ornithine+blood 0 0.535294118 0 kegg serum_aminoacids NA 0.175 no no no no no no d18:0-18:3-SM+blood L-Ornithine+blood 0 0 -0.417435897 serum_phospholipids serum_aminoacids 0.0879 0.175 no dn no no no no d18:1-14:0-SM+blood L-Ornithine+blood -0.622556391 -0.642156863 -0.44957265 serum_phospholipids serum_aminoacids 0.94 0.175 no no no no no no d18:1-14:1-SM+blood L-Ornithine+blood -0.676691729 -0.509803922 -0.543931624 serum_phospholipids serum_aminoacids 0.0952 0.175 no dn no no no no d18:1-16:1-SM+blood L-Ornithine+blood 0 0 -0.415384615 serum_phospholipids serum_aminoacids 0.2 0.175 no no no no no no d18:1-18:1-SM+blood L-Ornithine+blood 0 0 -0.488547009 serum_phospholipids serum_aminoacids 0.916 0.175 no no no no no no d18:1-20:0-SM+blood L-Ornithine+blood -0.529323308 0 0 serum_phospholipids serum_aminoacids 0.933 0.175 no no no no no no DHA+blood L-Ornithine+blood -0.494736842 0 0 serum_ARA serum_aminoacids 0.872 0.175 no no no no no no Diabetic cardiomyopathy L-Ornithine+blood 0 0 -0.411538462 kegg serum_aminoacids NA 0.175 no no no no no no DL-methionine sulfoxide+blood L-Ornithine+blood 0.706766917 0.490196078 0 serum_aminoacids serum_aminoacids 0.302 0.175 no no no no no no DPA+blood L-Ornithine+blood 0 0 0.420854701 serum_ARA serum_aminoacids 0.519 0.175 no no no no no no Epstein-Barr virus infection L-Ornithine+blood 0 0 -0.453076923 kegg serum_aminoacids NA 0.175 no no no no no no Focal adhesion L-Ornithine+blood 0 -0.55 0 kegg serum_aminoacids NA 0.175 no up up no no no FoxO signaling pathway L-Ornithine+blood 0 0 0.424615385 kegg serum_aminoacids NA 0.175 no no no no no no Glycolysis / Gluconeogenesis L-Ornithine+blood 0 -0.535294118 0 kegg serum_aminoacids NA 0.175 no no no no no no Graft-versus-host disease L-Ornithine+blood 0 0 -0.513076923 kegg serum_aminoacids NA 0.175 no no no no no no HDCA+blood L-Ornithine+blood 0 0 0.47447742 serum_bileacids serum_aminoacids 0.483 0.175 no no no no no no Hematopoietic cell lineage L-Ornithine+blood 0 -0.608823529 0 kegg serum_aminoacids NA 0.175 no no no no no no Hepatitis C L-Ornithine+blood 0 0.502941176 0 kegg serum_aminoacids NA 0.175 no no no no no no Hepatocellular carcinoma L-Ornithine+blood 0 -0.517647059 0 kegg serum_aminoacids NA 0.175 no no no no no no heptanoic acid C7+blood L-Ornithine+blood 0 0 0.478290598 serum_mcfa serum_aminoacids 8.27E-11 0.175 dn dn no no no no Herpes simplex virus 1 infection L-Ornithine+blood 0 0 -0.431538462 kegg serum_aminoacids NA 0.175 no no no no no no Human cytomegalovirus infection L-Ornithine+blood 0 0 -0.553846154 kegg serum_aminoacids NA 0.175 no no dn no no no Human immunodeficiency virus 1 infection L-Ornithine+blood 0 0 -0.485384615 kegg serum_aminoacids NA 0.175 no no no no no no Human T-cell leukemia virus 1 infection L-Ornithine+blood 0 0 -0.521538462 kegg serum_aminoacids NA 0.175 no no no no no no Huntington disease L-Ornithine+blood 0 0 -0.456153846 kegg serum_aminoacids NA 0.175 no no no no no no Hypertrophic cardiomyopathy L-Ornithine+blood 0 -0.567647059 0 kegg serum_aminoacids NA 0.175 no up up no no no Inflammatory bowel disease L-Ornithine+blood 0 -0.708823529 0 kegg serum_aminoacids NA 0.175 no no no no no no Intestinal immune network for IgA production L-Ornithine+blood 0 -0.635294118 0 kegg serum_aminoacids NA 0.175 no no no no no no iso-LCA+blood L-Ornithine+blood 0 0 0.666135246 serum_bileacids serum_aminoacids 0.507 0.175 no no no no no no L-Alanine+blood L-Ornithine+blood 0.772932331 0 0 yes serum_aminoacids serum_aminoacids 0.00138 0.175 up up no no no no L-Asparagine+blood L-Ornithine+blood 0.643609023 0 0 serum_aminoacids serum_aminoacids 0.784 0.175 no no no no no no L-Aspartic acid+blood L-Ornithine+blood 0 0 0.52 yes serum_aminoacids serum_aminoacids 0.0226 0.175 up up no no no no L-Citrulline+blood L-Ornithine+blood 0.458646617 0.620098039 0.427008547 serum_aminoacids serum_aminoacids 0.534 0.175 no no no no no no L-Glutamic acid+blood L-Ornithine+blood 0.496240602 0 0.452991453 yes serum_aminoacids serum_aminoacids 6.20E-05 0.175 up up no no no no L-Glutamine+blood L-Ornithine+blood 0.616541353 0 0 serum_aminoacids serum_aminoacids 0.639 0.175 no no no no no no L-Histidine+blood L-Ornithine+blood 0 0 0.545299145 serum_aminoacids serum_aminoacids 0.109 0.175 no no no no no no L-Isoleucine+blood L-Ornithine+blood 0 0 0.435897436 yes serum_aminoacids serum_aminoacids 5.47E-06 0.175 up up no no no no L-Lysine+blood L-Ornithine+blood 0.619548872 0 0.470769231 yes serum_aminoacids serum_aminoacids 0.0107 0.175 no up no no no no L-Phenylalanine+stool L-Ornithine+blood 0 0 0.496240602 stool_cometabolism serum_aminoacids 0.398 0.175 no no no no no no L-Tryptophan+stool L-Ornithine+blood 0 0 0.458646617 stool_cometabolism serum_aminoacids 0.557 0.175 no no no no no no L-Tyrosine+stool L-Ornithine+blood 0 0 0.554887218 stool_cometabolism serum_aminoacids 0.44 0.175 no no no no no no Leishmaniasis L-Ornithine+blood -0.49122807 0 0 kegg serum_aminoacids NA 0.175 no no no no no no MicroRNAs in cancer L-Ornithine+blood 0 0.517647059 0 kegg serum_aminoacids NA 0.175 no no no no no no Mineral absorption L-Ornithine+blood 0.468421053 0 0 kegg serum_aminoacids NA 0.175 no no no no no no Non-alcoholic fatty liver disease L-Ornithine+blood 0 0 -0.492307692 kegg serum_aminoacids NA 0.175 no no no no no no nutriCA+stool L-Ornithine+blood 0 -0.669752957 0 stool_bileacids serum_aminoacids 0.481 0.175 no no no no no no Oxidative phosphorylation L-Ornithine+blood 0 0 -0.431538462 kegg serum_aminoacids NA 0.175 no no no no no no Platelet activation L-Ornithine+blood 0 -0.561764706 0 kegg serum_aminoacids NA 0.175 no no no no no no Primary immunodeficiency L-Ornithine+blood -0.512280702 0 0 kegg serum_aminoacids NA 0.175 no no no no no no Prion disease L-Ornithine+blood 0 0 -0.462307692 kegg serum_aminoacids NA 0.175 no no no no no no Progesterone-mediated oocyte maturation L-Ornithine+blood -0.492982456 0 0 kegg serum_aminoacids NA 0.175 no no no no no no Retrograde endocannabinoid signaling L-Ornithine+blood 0 0 -0.441538462 kegg serum_aminoacids NA 0.175 no no up no no no Ribosome biogenesis in eukaryotes L-Ornithine+blood -0.457894737 0 0 kegg serum_aminoacids NA 0.175 no no no no no no RNA transport L-Ornithine+blood -0.496491228 0 0 kegg serum_aminoacids NA 0.175 no no no no no no Spliceosome L-Ornithine+blood -0.526315789 0 0 kegg serum_aminoacids NA 0.175 no no no no no no Thermogenesis L-Ornithine+blood 0 0 -0.427692308 kegg serum_aminoacids NA 0.175 no no no no no no Transcriptional misregulation in cancer L-Ornithine+blood 0 0.535294118 0 kegg serum_aminoacids NA 0.175 no no no no no no Type I diabetes mellitus L-Ornithine+blood 0 0 -0.526153846 kegg serum_aminoacids NA 0.175 no no no no no no UDCA+stool L-Ornithine+blood 0 0 -0.452631579 stool_bileacids serum_aminoacids 0.266 0.175 no no no no no no Vibrio cholerae infection L-Ornithine+blood 0 -0.5 0 kegg serum_aminoacids NA 0.175 no no no no no no Viral carcinogenesis L-Ornithine+blood 0 0 -0.425384615 kegg serum_aminoacids NA 0.175 no no no no no no Viral myocarditis L-Ornithine+blood 0 0 -0.527692308 kegg serum_aminoacids NA 0.175 no no no no no no 12-HEPE+blood L-Phenylalanine+blood 0.483785237 -0.612531804 0 yes serum_ARA serum_aminoacids 0.312 0.0103 no no no up up no 14:0/18:0-PC+blood L-Phenylalanine+blood -0.520300752 0 0 yes serum_phospholipids serum_aminoacids 0.00289 0.0103 up up no up up no 14:0/20:4-PC+blood L-Phenylalanine+blood 0 -0.546568627 0 yes serum_phospholipids serum_aminoacids 0.486 0.0103 no no no up up no 15-HETE+blood L-Phenylalanine+blood 0 0 -0.413155187 yes serum_ARA serum_aminoacids 0.819 0.0103 no no no up up no 16:0/18:2-PC+blood L-Phenylalanine+blood 0.461654135 0 0 yes serum_phospholipids serum_aminoacids 3.24E-06 0.0103 no up up up up no 16:0/20:5-PC+blood L-Phenylalanine+blood 0 -0.664215686 0 yes serum_phospholipids serum_aminoacids 0.628 0.0103 no no no up up no 16:0/22:0-PE+blood L-Phenylalanine+blood 0.446616541 0 0 yes serum_phospholipids serum_aminoacids 0.00839 0.0103 dn no up up up no 16:0/22:6-PC+blood L-Phenylalanine+blood 0.515789474 0 0 yes serum_phospholipids serum_aminoacids 4.53E-05 0.0103 no up up up up no 18:0/22:6-PC+blood L-Phenylalanine+blood 0.535338346 0 0.443418803 yes serum_phospholipids serum_aminoacids 0.0775 0.0103 no no up up up no 18:1/16:0-PC+blood L-Phenylalanine+blood 0.44962406 0 0 yes serum_phospholipids serum_aminoacids 2.43E-05 0.0103 no up up up up no 18:1/16:0-PE+blood L-Phenylalanine+blood -0.50075188 0 0 yes serum_phospholipids serum_aminoacids 0.000182 0.0103 up up no up up no 18:2-LPA+blood L-Phenylalanine+blood 0 0.546568627 0 yes serum_phospholipids serum_aminoacids 0.00684 0.0103 dn no up up up no 18:2/20:4-PC+blood L-Phenylalanine+blood 0 -0.546568627 0 yes serum_phospholipids serum_aminoacids 0.0145 0.0103 no no up up up no 18:3/16:0-PE+blood L-Phenylalanine+blood -0.569924812 0 0 yes serum_phospholipids serum_aminoacids 0.00149 0.0103 up up no up up no 18:3/18:2-PC+blood L-Phenylalanine+blood 0 0 -0.414017094 yes serum_phospholipids serum_aminoacids 0.0394 0.0103 no no up up up no 18:3n6+blood L-Phenylalanine+blood -0.65112782 0 0 yes serum_fattyacid serum_aminoacids 0.0463 0.0103 up no dn up up no 20:0+blood L-Phenylalanine+blood 0 -0.524509804 0 yes yes serum_fattyacid serum_aminoacids 0.000278 0.0103 dn no up up up no 20:1/20:4-PC+blood L-Phenylalanine+blood 0.571428571 0 0.413333333 yes serum_phospholipids serum_aminoacids 0.0419 0.0103 no no up up up no 20:2/18:1-PE+blood L-Phenylalanine+blood -0.503759398 0 0 yes serum_phospholipids serum_aminoacids 0.00208 0.0103 up up no up up no 20:3-LPE+blood L-Phenylalanine+blood -0.518796992 0 0 yes serum_phospholipids serum_aminoacids 0.084 0.0103 no up no up up no 20:5/18:0-PC+blood L-Phenylalanine+blood 0.535338346 0 0 yes serum_phospholipids serum_aminoacids 3.97E-06 0.0103 no up up up up no 20:5n3+blood L-Phenylalanine+blood 0 -0.629901961 0 yes serum_fattyacid serum_aminoacids 0.988 0.0103 no no no up up no 22:0/16:0-PE+blood L-Phenylalanine+blood 0.457142857 0 0 yes serum_phospholipids serum_aminoacids 0.091 0.0103 no no up up up no 22:2-LPA+blood L-Phenylalanine+blood 0 0.575980392 0 yes serum_phospholipids serum_aminoacids 0.0443 0.0103 dn no no up up no 22:6-LPC+blood L-Phenylalanine+blood 0 0 0.532307692 yes serum_phospholipids serum_aminoacids 0.127 0.0103 no no up up up no Acute myeloid leukemia L-Phenylalanine+blood 0 0 0.47 yes kegg serum_aminoacids NA 0.0103 no no no up up no Adrenergic signaling in cardiomyocytes L-Phenylalanine+blood 0.471929825 0 0 yes kegg serum_aminoacids NA 0.0103 no no up up up no AGE-RAGE signaling pathway in diabetic complications L-Phenylalanine+blood 0.478947368 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Alistipes L-Phenylalanine+blood 0 -0.505211622 0 yes Genus serum_aminoacids 0.0114 0.0103 no up no up up no Arrhythmogenic right ventricular cardiomyopathy L-Phenylalanine+blood 0 0 -0.460769231 yes kegg serum_aminoacids NA 0.0103 no up up up up no Asthma L-Phenylalanine+blood 0 0 -0.540769231 yes kegg serum_aminoacids NA 0.0103 no no no up up no Bifidobacterium L-Phenylalanine+blood 0 0.603310966 0 acetate-producing yes Genus serum_aminoacids 0.105 0.0103 no dn no up up no Biosynthesis of amino acids L-Phenylalanine+blood -0.526315789 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Blautia L-Phenylalanine+blood 0 0.715686275 0 acetate-producing yes Genus serum_aminoacids 1.36E-05 0.0103 up dn dn up up no Breast cancer L-Phenylalanine+blood 0.557894737 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Butyricimonas L-Phenylalanine+blood 0.455955496 0 0 butyrate-producing yes Genus serum_aminoacids 0.17 0.0103 no no no up up no cAMP signaling pathway L-Phenylalanine+blood 0.50877193 0 0 yes yes kegg serum_aminoacids NA 0.0103 no up up up up no Carbon metabolism L-Phenylalanine+blood -0.605263158 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Cell adhesion molecules L-Phenylalanine+blood 0 0 -0.407692308 yes kegg serum_aminoacids NA 0.0103 no no no up up no Chemical carcinogenesis - receptor activation L-Phenylalanine+blood 0.496491228 -0.726470588 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Choline metabolism in cancer L-Phenylalanine+blood 0.557894737 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Choline+blood L-Phenylalanine+blood 0.535338346 0 0.500854701 yes serum_choline serum_aminoacids 0.0395 0.0103 no up no up up no Cholinergic synapse L-Phenylalanine+blood 0 -0.617647059 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Clostridium L-Phenylalanine+blood 0 0.58614358 0 yes Genus serum_aminoacids 0.925 0.0103 no no no up up no Colorectal cancer L-Phenylalanine+blood 0.531578947 -0.558823529 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Creatinine+blood L-Phenylalanine+blood 0.563909774 0.647058824 0 yes serum_choline serum_aminoacids 0.437 0.0103 no no no up up no Cushing syndrome L-Phenylalanine+blood 0 -0.517647059 0 yes kegg serum_aminoacids NA 0.0103 no no up up up no Cysteine+blood L-Phenylalanine+blood 0 0 0.459145299 yes yes serum_aminoacids serum_aminoacids 1.81E-07 0.0103 dn up up up up no Cystine+blood L-Phenylalanine+blood 0 0.713235294 0 yes yes serum_aminoacids serum_aminoacids 0.00028 0.0103 up up no up up no d18:0-18:3-SM+blood L-Phenylalanine+blood 0 0 -0.408547009 yes serum_phospholipids serum_aminoacids 0.0879 0.0103 no dn no up up no d18:1-22:1-SM+blood L-Phenylalanine+blood -0.464661654 0 0 yes serum_phospholipids serum_aminoacids 0.222 0.0103 no no no up up no decanoic acid C10+blood L-Phenylalanine+blood 0 0.495098039 0 yes serum_mcfa serum_aminoacids 6.64E-11 0.0103 dn dn no up up no Dilated cardiomyopathy L-Phenylalanine+blood 0 0 -0.443846154 yes kegg serum_aminoacids NA 0.0103 no up up up up no DL-methionine sulfoxide+blood L-Phenylalanine+blood 0 0.683823529 0.506324786 yes serum_aminoacids serum_aminoacids 0.302 0.0103 no no no up up no DMG+blood L-Phenylalanine+blood 0 0.696078431 0.551452991 yes serum_choline serum_aminoacids 0.909 0.0103 no no no up up no Dorea L-Phenylalanine+blood 0 0.593137255 0 yes Genus serum_aminoacids 0.00362 0.0103 up no dn up up no Endocrine resistance L-Phenylalanine+blood 0.496491228 -0.558823529 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no ErbB signaling pathway L-Phenylalanine+blood 0.624561404 -0.526470588 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Estrogen signaling pathway L-Phenylalanine+blood 0 0 -0.406153846 yes kegg serum_aminoacids NA 0.0103 no no no up up no Ethanolamine+blood L-Phenylalanine+blood 0 0 0.621196581 yes serum_aminoacids serum_aminoacids 0.122 0.0103 up no no up up no Fc epsilon RI signaling pathway L-Phenylalanine+blood 0.605263158 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Focal adhesion L-Phenylalanine+blood 0 0 -0.565384615 yes kegg serum_aminoacids NA 0.0103 no up up up up no FoxO signaling pathway L-Phenylalanine+blood 0.507017544 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Gastric cancer L-Phenylalanine+blood 0.596491228 -0.541176471 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no GCDCA+stool L-Phenylalanine+blood 0 0.654545455 -0.491729323 yes yes stool_bileacids serum_aminoacids 0.0471 0.0103 no dn no up up no GDCA+stool L-Phenylalanine+blood 0 0.715263815 -0.490964412 yes stool_bileacids serum_aminoacids 0.656 0.0103 no no no up up no Gemmiger L-Phenylalanine+blood 0 0 0.429795151 butyrate-producing yes Genus serum_aminoacids 0.595 0.0103 no no no up up no Glioma L-Phenylalanine+blood 0.480701754 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Glutathione metabolism L-Phenylalanine+blood -0.480701754 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Glycolysis / Gluconeogenesis L-Phenylalanine+blood -0.585964912 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no "Growth hormone synthesis, secretion and action" L-Phenylalanine+blood 0.531578947 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Hematopoietic cell lineage L-Phenylalanine+blood 0 0 -0.476153846 yes kegg serum_aminoacids NA 0.0103 no no no up up no Hepatitis B L-Phenylalanine+blood 0.501754386 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no heptanoic acid C7+blood L-Phenylalanine+blood 0 0 0.442735043 yes serum_mcfa serum_aminoacids 8.27E-11 0.0103 dn dn no up up no Hippo signaling pathway L-Phenylalanine+blood 0 0 -0.534615385 yes kegg serum_aminoacids NA 0.0103 no no no up up no Hypertrophic cardiomyopathy L-Phenylalanine+blood 0 0 -0.440769231 yes kegg serum_aminoacids NA 0.0103 no up up up up no Inflammatory bowel disease L-Phenylalanine+blood 0 0 -0.476923077 yes kegg serum_aminoacids NA 0.0103 no no no up up no Influenza A L-Phenylalanine+blood 0 0.570588235 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Intestinal immune network for IgA production L-Phenylalanine+blood 0 0 -0.620769231 yes kegg serum_aminoacids NA 0.0103 no no no up up no iso-DCA+blood L-Phenylalanine+blood 0 0 0.528205128 yes serum_bileacids serum_aminoacids 0.38 0.0103 no no no up up no iso-heptanoic acid C7+blood L-Phenylalanine+blood -0.461654135 0 0 yes serum_mcfa serum_aminoacids 0.00256 0.0103 up up no up up no isovaleric acid iso-C5+blood L-Phenylalanine+blood 0 -0.485294118 0 yes serum_scfa serum_aminoacids 0.117 0.0103 no no no up up no L-Arginine+blood L-Phenylalanine+blood 0.521804511 0.583333333 0.432478632 yes serum_aminoacids serum_aminoacids 0.316 0.0103 no no no up up no L-Glutamic acid+blood L-Phenylalanine+blood 0 0.713235294 0.419487179 yes yes serum_aminoacids serum_aminoacids 6.20E-05 0.0103 up up no up up no L-Glutamine+blood L-Phenylalanine+blood 0 0.534313725 0 yes serum_aminoacids serum_aminoacids 0.639 0.0103 no no no up up no L-Histidine+blood L-Phenylalanine+blood 0.6 0 0.552820513 yes serum_aminoacids serum_aminoacids 0.109 0.0103 no no no up up no L-Isoleucine+blood L-Phenylalanine+blood 0.551879699 0.779411765 0.832478632 yes yes serum_aminoacids serum_aminoacids 5.47E-06 0.0103 up up no up up no L-Leucine+blood L-Phenylalanine+blood 0 0 0.738803419 yes yes serum_aminoacids serum_aminoacids 3.22E-05 0.0103 up up no up up no L-Lysine+blood L-Phenylalanine+blood 0.628571429 0.713235294 0.625299145 yes yes serum_aminoacids serum_aminoacids 0.0107 0.0103 no up no up up no L-Methionine+blood L-Phenylalanine+blood 0.836090226 0.720588235 0.423589744 yes serum_aminoacids serum_aminoacids 0.626 0.0103 no no no up up no L-Ornithine+blood L-Phenylalanine+blood 0 0 0.420854701 yes serum_aminoacids serum_aminoacids 0.175 0.0103 no no no up up no Leishmaniasis L-Phenylalanine+blood -0.496491228 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Leukocyte transendothelial migration L-Phenylalanine+blood 0 0 -0.405384615 yes kegg serum_aminoacids NA 0.0103 no no no up up no MAPK signaling pathway L-Phenylalanine+blood 0 -0.541176471 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no mRNA surveillance pathway L-Phenylalanine+blood 0.580701754 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Non-small cell lung cancer L-Phenylalanine+blood 0.601754386 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Oscillospira L-Phenylalanine+blood 0 0 0.408547009 LPS-producing yes Genus serum_aminoacids 0.62 0.0103 no no no up up no Pancreatic cancer L-Phenylalanine+blood 0.485964912 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Parabacteroides L-Phenylalanine+blood 0 -0.522058824 0.455804418 yes Genus serum_aminoacids 4.19E-05 0.0103 no up up up up no Pathways in cancer L-Phenylalanine+blood 0.652631579 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Phosphatidylinositol signaling system L-Phenylalanine+blood 0.456140351 -0.526470588 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Phospholipase D signaling pathway L-Phenylalanine+blood 0.584210526 0 0 yes kegg serum_aminoacids NA 0.0103 no up up up up no Prolactin signaling pathway L-Phenylalanine+blood 0.478947368 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Proteasome L-Phenylalanine+blood 0 0 0.462307692 yes kegg serum_aminoacids NA 0.0103 no no no up up no Regulation of actin cytoskeleton L-Phenylalanine+blood -0.464912281 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Rheumatoid arthritis L-Phenylalanine+blood 0 0 -0.518461538 yes kegg serum_aminoacids NA 0.0103 no no no up up no RNA degradation L-Phenylalanine+blood 0.466666667 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Roseburia L-Phenylalanine+blood 0 0.488044236 0 butyrate-producing yes Genus serum_aminoacids 0.495 0.0103 no no no up up no Salmonella infection L-Phenylalanine+blood 0 0.5 -0.457692308 yes kegg serum_aminoacids NA 0.0103 no no no up up no Signaling pathways regulating pluripotency of stem cells L-Phenylalanine+blood 0.610526316 -0.602941176 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Sphingolipid signaling pathway L-Phenylalanine+blood 0.50877193 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Thyroid hormone signaling pathway L-Phenylalanine+blood 0 0 -0.413846154 yes kegg serum_aminoacids NA 0.0103 no no no up up no Toxoplasmosis L-Phenylalanine+blood 0 0 -0.413846154 yes kegg serum_aminoacids NA 0.0103 no no no up up no VEGF signaling pathway L-Phenylalanine+blood 0.573684211 0 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no Yersinia infection L-Phenylalanine+blood 0 0.55 0 yes kegg serum_aminoacids NA 0.0103 no no no up up no 5-Hydroxytryptamine+stool L-Phenylalanine+stool 0 0 0.486166008 stool_cometabolism stool_cometabolism 0.00862 0.398 dn dn no no no no ACA+stool L-Phenylalanine+stool 0 -0.591312396 0 stool_bileacids stool_cometabolism 0.417 0.398 no no no no no no Allograft rejection L-Phenylalanine+stool 0 0 -0.566346697 kegg stool_cometabolism NA 0.398 no no no no no no Antigen processing and presentation L-Phenylalanine+stool 0 0 -0.46809712 kegg stool_cometabolism NA 0.398 no no no no no no Apelin signaling pathway L-Phenylalanine+stool -0.486068111 0 0 kegg stool_cometabolism NA 0.398 no no no no no no Autoimmune thyroid disease L-Phenylalanine+stool 0 0 -0.566346697 kegg stool_cometabolism NA 0.398 no no no no no no Butyric acid+stool L-Phenylalanine+stool -0.492260062 0 0 yes stool_scfa stool_cometabolism 0.102 0.398 dn no no no no no Butyricicoccus L-Phenylalanine+stool 0 0 -0.532132374 butyrate-producing Genus stool_cometabolism 0.852 0.398 no no no no no no CA+stool L-Phenylalanine+stool 0 0 -0.56027668 stool_bileacids stool_cometabolism 0.827 0.398 no no no no no no CDCA+stool L-Phenylalanine+stool 0 0 -0.589920949 stool_bileacids stool_cometabolism 0.663 0.398 no no no no no no Cell adhesion molecules L-Phenylalanine+stool 0 0 -0.558441558 kegg stool_cometabolism NA 0.398 no no no no no no Cellular senescence L-Phenylalanine+stool 0 0 -0.566346697 kegg stool_cometabolism NA 0.398 no no no no no no Clostridium L-Phenylalanine+stool 0.486992066 0 0 Genus stool_cometabolism 0.925 0.398 no no no no no no DCA+stool L-Phenylalanine+stool -0.496388029 0 0 stool_bileacids stool_cometabolism 0.195 0.398 no no no no no no Endocytosis L-Phenylalanine+stool 0 0 -0.53811406 kegg stool_cometabolism NA 0.398 no no no no no no Epstein-Barr virus infection L-Phenylalanine+stool 0 0 -0.488424619 kegg stool_cometabolism NA 0.398 no no no no no no GCDCA+stool L-Phenylalanine+stool 0 -0.657342657 0 yes stool_bileacids stool_cometabolism 0.0471 0.398 no dn no no no no Gemmiger L-Phenylalanine+stool -0.649458011 0 0 butyrate-producing Genus stool_cometabolism 0.595 0.398 no no no no no no Graft-versus-host disease L-Phenylalanine+stool 0 0 -0.56295878 kegg stool_cometabolism NA 0.398 no no no no no no Herpes simplex virus 1 infection L-Phenylalanine+stool 0 0 -0.428571429 kegg stool_cometabolism NA 0.398 no no no no no no Human cytomegalovirus infection L-Phenylalanine+stool 0 0 -0.473743648 kegg stool_cometabolism NA 0.398 no no dn no no no Human immunodeficiency virus 1 infection L-Phenylalanine+stool 0 0 -0.465838509 kegg stool_cometabolism NA 0.398 no no no no no no Human papillomavirus infection L-Phenylalanine+stool 0 0 -0.480519481 kegg stool_cometabolism NA 0.398 no no no no no no Human T-cell leukemia virus 1 infection L-Phenylalanine+stool 0 0 -0.459062676 kegg stool_cometabolism NA 0.398 no no no no no no Indole-3-Acetic acid+stool L-Phenylalanine+stool 0.529411765 0 0.726284585 stool_cometabolism stool_cometabolism 0.304 0.398 no no no no no no Isobutyric acid+stool L-Phenylalanine+stool 0 0.664335664 0.543478261 stool_scfa stool_cometabolism 0.408 0.398 no no no no no no Isovaleric acid+stool L-Phenylalanine+stool 0 0.706293706 0.520750988 stool_scfa stool_cometabolism 0.343 0.398 no no no no no no Kynurenic acid+stool L-Phenylalanine+stool 0 0.608391608 0 stool_cometabolism stool_cometabolism 0.037 0.398 dn dn no no no no Legionellosis L-Phenylalanine+stool -0.51496388 0 0 kegg stool_cometabolism NA 0.398 no no no no no no Methanobrevibacter L-Phenylalanine+stool 0 0 0.444554224 Genus stool_cometabolism 0.629 0.398 no no no no no no mTOR signaling pathway L-Phenylalanine+stool -0.498452012 0 0 kegg stool_cometabolism NA 0.398 no no no no no no Natural killer cell mediated cytotoxicity L-Phenylalanine+stool 0 0 -0.496329757 kegg stool_cometabolism NA 0.398 no no no no no no Neutrophil extracellular trap formation L-Phenylalanine+stool 0.475748194 0 0 kegg stool_cometabolism NA 0.398 no no no no no no Phagosome L-Phenylalanine+stool 0 0 -0.464709204 kegg stool_cometabolism NA 0.398 no no no no no no Purine metabolism L-Phenylalanine+stool -0.572755418 0 0 kegg stool_cometabolism NA 0.398 no no no no no no RNA transport L-Phenylalanine+stool -0.492260062 0 0 kegg stool_cometabolism NA 0.398 no no no no no no Succinivibrio L-Phenylalanine+stool 0 0 -0.456470037 Genus stool_cometabolism 0.138 0.398 no no no no no no Tuberculosis L-Phenylalanine+stool 0.496388029 0 0 kegg stool_cometabolism NA 0.398 no no dn no no no Type I diabetes mellitus L-Phenylalanine+stool 0 0 -0.569734613 kegg stool_cometabolism NA 0.398 no no no no no no Viral carcinogenesis L-Phenylalanine+stool 0 0 -0.5256917 kegg stool_cometabolism NA 0.398 no no no no no no Viral myocarditis L-Phenylalanine+stool 0 0 -0.561829475 kegg stool_cometabolism NA 0.398 no no no no no no ¦Ø-MCA+stool L-Phenylalanine+stool 0 -0.701819726 0 stool_bileacids stool_cometabolism 0.919 0.398 no no no no no no 16:0/16:0-PC+blood L-Phenylalanine+urine 0.882352941 0 0 serum_phospholipids urine_cometabolism 0.00079 0.0908 no up up no up no 16:0/18:0-PC+blood L-Phenylalanine+urine 0.556372549 0 0 serum_phospholipids urine_cometabolism 0.521 0.0908 no no no no up no 16:0/18:1-PC+blood L-Phenylalanine+urine 0.536764706 0 0 serum_phospholipids urine_cometabolism 6.15E-07 0.0908 up up up no up no 16:0/18:2-PC+blood L-Phenylalanine+urine 0.593137255 0 0 serum_phospholipids urine_cometabolism 3.24E-06 0.0908 no up up no up no 16:0/20:3-PC+blood L-Phenylalanine+urine 0.656862745 0 0 serum_phospholipids urine_cometabolism 5.43E-06 0.0908 no up up no up no 16:0/22:6-PC+blood L-Phenylalanine+urine 0.607843137 0 0 serum_phospholipids urine_cometabolism 4.53E-05 0.0908 no up up no up no 16:1/16:0-PC+blood L-Phenylalanine+urine 0.602941176 0 0 serum_phospholipids urine_cometabolism 0.0215 0.0908 no up up no up no 16:1/16:1-PC+blood L-Phenylalanine+urine 0.575980392 0 0 serum_phospholipids urine_cometabolism 0.0177 0.0908 no no up no up no 18:0/16:0-PC+blood L-Phenylalanine+urine 0.56127451 0 0 serum_phospholipids urine_cometabolism 9.64E-07 0.0908 up up up no up no 18:0/18:1-PE+blood L-Phenylalanine+urine -0.485294118 0 0 serum_phospholipids urine_cometabolism 0.00716 0.0908 up up no no up no 18:0/18:2-PC+blood L-Phenylalanine+urine 0.605392157 0 0 serum_phospholipids urine_cometabolism 1.74E-06 0.0908 no up up no up no 18:0/18:2-PI+blood L-Phenylalanine+urine 0 0 0.548051948 serum_phospholipids urine_cometabolism 0.179 0.0908 no no no no up no 18:0/20:4-PI+blood L-Phenylalanine+urine 0 0 0.566233766 serum_phospholipids urine_cometabolism 0.167 0.0908 no no no no up no 18:0/22:6-PA+blood L-Phenylalanine+urine 0.553921569 0 0 serum_phospholipids urine_cometabolism 0.22 0.0908 no no no no up no 18:0/22:6-PC+blood L-Phenylalanine+urine 0.482843137 0 0 serum_phospholipids urine_cometabolism 0.0775 0.0908 no no up no up no 18:1/16:0-PC+blood L-Phenylalanine+urine 0.580882353 0 0 serum_phospholipids urine_cometabolism 2.43E-05 0.0908 no up up no up no 18:1/18:0-PC+blood L-Phenylalanine+urine 0.669117647 0 0 serum_phospholipids urine_cometabolism 1.83E-06 0.0908 no up up no up no 18:1/18:1-PC+blood L-Phenylalanine+urine 0.593137255 0 0 serum_phospholipids urine_cometabolism 1.34E-05 0.0908 no up up no up no 18:2/16:0-PC+blood L-Phenylalanine+urine 0.580882353 0 0 serum_phospholipids urine_cometabolism 8.67E-05 0.0908 no up up no up no 2-hydroxyhippuric acid+urine L-Phenylalanine+urine -0.696240602 0 -0.504273504 urine_cometabolism urine_cometabolism 0.215 0.0908 no no no no up no 2-hydroxyphenylacetic acid+urine L-Phenylalanine+urine 0 -0.496491228 -0.453675214 urine_cometabolism urine_cometabolism 0.763 0.0908 no no no no up no 20:1-LPA+blood L-Phenylalanine+urine 0 -0.620879121 0 serum_phospholipids urine_cometabolism 0.0187 0.0908 dn dn no no up no 20:3/18:0-PC+blood L-Phenylalanine+urine 0.62745098 0 0 serum_phospholipids urine_cometabolism 0.296 0.0908 no no no no up no 20:5/18:0-PC+blood L-Phenylalanine+urine 0.595588235 0 0 serum_phospholipids urine_cometabolism 3.97E-06 0.0908 no up up no up no "3-(3,4-dihydroxyphenyl)propionic acid+urine" L-Phenylalanine+urine 0 0 0.64034188 urine_cometabolism urine_cometabolism 0.0125 0.0908 up up no no up no 3-Hydroxy-L-kynurenine+urine L-Phenylalanine+urine 0.732330827 0.678947368 0.72034188 urine_cometabolism urine_cometabolism 0.401 0.0908 no no no no up no 3-Hydroxytyramine hydrochloride+urine L-Phenylalanine+urine 0 0 0.50017094 urine_cometabolism urine_cometabolism 0.288 0.0908 no no no no up no 5-Hydroxytryptamine+urine L-Phenylalanine+urine 0 0.477192982 0 urine_cometabolism urine_cometabolism 0.171 0.0908 no no no no up no Alcoholism L-Phenylalanine+urine 0 -0.61754386 0 kegg urine_cometabolism NA 0.0908 no no no no up no Amoebiasis L-Phenylalanine+urine 0 -0.566666667 0 kegg urine_cometabolism NA 0.0908 no no no no up no Anaerostipes L-Phenylalanine+urine 0.572834267 0 0 butyrate-producing Genus urine_cometabolism 0.568 0.0908 no no no no up no Apelin signaling pathway L-Phenylalanine+urine 0 0.484210526 0 kegg urine_cometabolism NA 0.0908 no no no no up no Arrhythmogenic right ventricular cardiomyopathy L-Phenylalanine+urine -0.475438596 0 0 kegg urine_cometabolism NA 0.0908 no up up no up no Axon guidance L-Phenylalanine+urine 0.456140351 0 0 kegg urine_cometabolism NA 0.0908 no up up no up no Biosynthesis of amino acids L-Phenylalanine+urine 0 -0.456140351 0 kegg urine_cometabolism NA 0.0908 no no no no up no Biosynthesis of cofactors L-Phenylalanine+urine -0.510526316 0 0 kegg urine_cometabolism NA 0.0908 no no no no up no Bladder cancer L-Phenylalanine+urine 0 -0.487719298 0 kegg urine_cometabolism NA 0.0908 no no no no up no CDCA+blood L-Phenylalanine+urine 0 0.769230769 0 serum_bileacids urine_cometabolism 0.506 0.0908 no no no no up no Colorectal cancer L-Phenylalanine+urine 0 0.514035088 0 kegg urine_cometabolism NA 0.0908 no no no no up no Coronavirus disease - COVID-19 L-Phenylalanine+urine 0 0 0.414615385 kegg urine_cometabolism NA 0.0908 no no no no up no Cysteine+blood L-Phenylalanine+urine 0 -0.642857143 0 yes serum_aminoacids urine_cometabolism 1.81E-07 0.0908 dn up up no up no Diabetic cardiomyopathy L-Phenylalanine+urine 0 0.456140351 0 kegg urine_cometabolism NA 0.0908 no no no no up no DL-Indole-3-lactic acid+urine L-Phenylalanine+urine 0 0 0.424957265 urine_cometabolism urine_cometabolism 0.00552 0.0908 up up no no up no DPA+blood L-Phenylalanine+urine 0 -0.56043956 0 serum_ARA urine_cometabolism 0.519 0.0908 no no no no up no EGFR tyrosine kinase inhibitor resistance L-Phenylalanine+urine 0 0.533333333 0.413846154 kegg urine_cometabolism NA 0.0908 no no no no up no EPA+blood L-Phenylalanine+urine 0.524509804 0 0 serum_ARA urine_cometabolism 0.212 0.0908 no no no no up no Fc epsilon RI signaling pathway L-Phenylalanine+urine 0 -0.5 0 kegg urine_cometabolism NA 0.0908 no no no no up no Fc gamma R-mediated phagocytosis L-Phenylalanine+urine 0 -0.466666667 0 kegg urine_cometabolism NA 0.0908 no no no no up no GABAergic synapse L-Phenylalanine+urine 0 -0.536842105 0 kegg urine_cometabolism NA 0.0908 no up up no up no GCA+blood L-Phenylalanine+urine -0.75 0 0 yes serum_bileacids urine_cometabolism 0.16 0.0908 no no no no up no GCDCA+blood L-Phenylalanine+urine -0.607843137 0 0 serum_bileacids urine_cometabolism 0.31 0.0908 no no no no up no GDCA+stool L-Phenylalanine+urine 0 0 -0.598760329 stool_bileacids urine_cometabolism 0.656 0.0908 no no no no up no Glutamatergic synapse L-Phenylalanine+urine 0 -0.573684211 0 kegg urine_cometabolism NA 0.0908 no up up no up no Glycine+blood L-Phenylalanine+urine 0 -0.818681319 0 serum_aminoacids urine_cometabolism 0.00408 0.0908 dn no up no up no GUDCA+blood L-Phenylalanine+urine -0.573529412 0 0 serum_bileacids urine_cometabolism 0.0766 0.0908 no no dn no up no HCA+blood L-Phenylalanine+urine 0 0.570849278 0 serum_bileacids urine_cometabolism 0.544 0.0908 no no no no up no Hepatitis C L-Phenylalanine+urine 0.535087719 0 0 kegg urine_cometabolism NA 0.0908 no no no no up no Hepatocellular carcinoma L-Phenylalanine+urine -0.471929825 0 0 kegg urine_cometabolism NA 0.0908 no no no no up no HIF-1 signaling pathway L-Phenylalanine+urine 0 0.49122807 0 kegg urine_cometabolism NA 0.0908 no no no no up no Hypertrophic cardiomyopathy L-Phenylalanine+urine -0.466666667 0 0 kegg urine_cometabolism NA 0.0908 no up up no up no IL-17 signaling pathway L-Phenylalanine+urine 0 -0.464912281 0 kegg urine_cometabolism NA 0.0908 no no no no up no Indole-3-Acetic acid+urine L-Phenylalanine+urine 0 -0.552631579 0 urine_cometabolism urine_cometabolism 0.657 0.0908 no no no no up no Insulin signaling pathway L-Phenylalanine+urine 0 0.503508772 0 kegg urine_cometabolism NA 0.0908 no no no no up no iso-DCA+blood L-Phenylalanine+urine 0.553921569 0 0 serum_bileacids urine_cometabolism 0.38 0.0908 no no no no up no L-Alanine+blood L-Phenylalanine+urine -0.5 0 0 yes serum_aminoacids urine_cometabolism 0.00138 0.0908 up up no no up no Long-term potentiation L-Phenylalanine+urine 0.487719298 0 0 kegg urine_cometabolism NA 0.0908 no no up no up no mRNA surveillance pathway L-Phenylalanine+urine 0 0.466666667 0 kegg urine_cometabolism NA 0.0908 no no no no up no mTOR signaling pathway L-Phenylalanine+urine 0 0.563157895 0 kegg urine_cometabolism NA 0.0908 no no no no up no MUFA%+blood L-Phenylalanine+urine 0 -0.725274725 0 serum_fattyacid urine_cometabolism 0.00142 0.0908 up no dn no up no Neurotrophin signaling pathway L-Phenylalanine+urine 0.521052632 0 0 kegg urine_cometabolism NA 0.0908 no no no no up no Neutrophil extracellular trap formation L-Phenylalanine+urine 0 -0.484210526 0 kegg urine_cometabolism NA 0.0908 no no no no up no Oxytocin signaling pathway L-Phenylalanine+urine -0.478947368 0 0 kegg urine_cometabolism NA 0.0908 no no no no up no Paraprevotella L-Phenylalanine+urine 0 0.494378563 0 Genus urine_cometabolism 0.118 0.0908 no no no no up no Phospholipase D signaling pathway L-Phenylalanine+urine 0 -0.526315789 0 kegg urine_cometabolism NA 0.0908 no up up no up no PI3K-Akt signaling pathway L-Phenylalanine+urine 0 0 0.427692308 yes kegg urine_cometabolism NA 0.0908 no up up no up no Porphyrin and chlorophyll metabolism L-Phenylalanine+urine -0.457894737 0 0 kegg urine_cometabolism NA 0.0908 no no no no up no Prevotella L-Phenylalanine+urine -0.475708081 0 0 acetate-producing Genus urine_cometabolism 0.287 0.0908 no no no no up no Progesterone-mediated oocyte maturation L-Phenylalanine+urine 0.505263158 0 0 kegg urine_cometabolism NA 0.0908 no no no no up no Protein processing in endoplasmic reticulum L-Phenylalanine+urine 0 0.545614035 0 kegg urine_cometabolism NA 0.0908 no no no no up no Proteoglycans in cancer L-Phenylalanine+urine 0 0.485964912 0 kegg urine_cometabolism NA 0.0908 no no no no up no PUFA%+blood L-Phenylalanine+urine 0.529411765 -0.774725275 0 serum_fattyacid urine_cometabolism 0.0013 0.0908 dn no up no up no Rheumatoid arthritis L-Phenylalanine+urine 0 0 -0.403846154 kegg urine_cometabolism NA 0.0908 no no no no up no Ribosome L-Phenylalanine+urine 0 0 0.414615385 kegg urine_cometabolism NA 0.0908 no no no no up no Ribosome biogenesis in eukaryotes L-Phenylalanine+urine 0 0.485964912 0 kegg urine_cometabolism NA 0.0908 no no no no up no RNA degradation L-Phenylalanine+urine 0 0.585964912 0 kegg urine_cometabolism NA 0.0908 no no no no up no RNA transport L-Phenylalanine+urine 0 0.484210526 0 kegg urine_cometabolism NA 0.0908 no no no no up no Sarcosine+blood L-Phenylalanine+urine -0.49754902 0 0 serum_choline urine_cometabolism 5.06E-05 0.0908 up up no no up no SFA%+blood L-Phenylalanine+urine 0.490196078 -0.785714286 0 serum_fattyacid urine_cometabolism 0.0236 0.0908 no up no no up no Sphingolipid signaling pathway L-Phenylalanine+urine 0.456140351 0 0 kegg urine_cometabolism NA 0.0908 no no no no up no TCA+stool L-Phenylalanine+urine 0 0 -0.512899897 stool_bileacids urine_cometabolism 0.458 0.0908 no no no no up no Transcriptional misregulation in cancer L-Phenylalanine+urine 0.543859649 0 0 kegg urine_cometabolism NA 0.0908 no no no no up no TUDCA+blood L-Phenylalanine+urine 0 0.598278863 0 yes serum_bileacids urine_cometabolism 0.0282 0.0908 no no dn no up no TXB2+blood L-Phenylalanine+urine 0 -0.613269028 0 yes serum_ARA urine_cometabolism 0.0644 0.0908 dn no no no up no UDCA+blood L-Phenylalanine+urine 0 0.571428571 0 yes serum_bileacids urine_cometabolism 0.0939 0.0908 no no dn no up no UFA%+blood L-Phenylalanine+urine 0 -0.862637363 0 serum_fattyacid urine_cometabolism 0.0236 0.0908 no dn no no up no Wnt signaling pathway L-Phenylalanine+urine 0 0.478947368 0 kegg urine_cometabolism NA 0.0908 no no no no up no 12-ketoDCA+blood L-Proline+blood 0.48290738 0 0 yes serum_bileacids serum_aminoacids 0.517 0.00265 no no no up up no "12,13-EPOME+blood" L-Proline+blood -0.545490999 0 0 yes serum_ARA serum_aminoacids 0.901 0.00265 no no no up up no 14:0/18:2-PC+blood L-Proline+blood 0 0 -0.424273504 yes serum_phospholipids serum_aminoacids 0.102 0.00265 no up no up up no 14:0+blood L-Proline+blood 0 0 -0.499487179 yes yes serum_fattyacid serum_aminoacids 0.00572 0.00265 up no dn up up no 16:0/16:0-PI+blood L-Proline+blood 0 0.512254902 0 yes serum_phospholipids serum_aminoacids 0.358 0.00265 no no no up up no 16:0/18:0-PC+blood L-Proline+blood 0 -0.551470588 0 yes serum_phospholipids serum_aminoacids 0.521 0.00265 no no no up up no 16:0/18:0-PS+blood L-Proline+blood -0.479699248 0 0 yes serum_phospholipids serum_aminoacids 0.377 0.00265 no no no up up no 16:0/18:2-PI+blood L-Proline+blood 0 0.700980392 0 yes serum_phospholipids serum_aminoacids 0.269 0.00265 no no no up up no 16:0/20:4-PC+blood L-Proline+blood 0 -0.647058824 0 yes serum_phospholipids serum_aminoacids 0.0262 0.00265 no up no up up no 16:0/22:6-PC+blood L-Proline+blood 0 -0.703431373 0 yes serum_phospholipids serum_aminoacids 4.53E-05 0.00265 no up up up up no 16:0+blood L-Proline+blood -0.517293233 0 -0.460512821 yes yes serum_fattyacid serum_aminoacids 0.00876 0.00265 up no no up up no 16:1+blood L-Proline+blood -0.566917293 0 0 yes yes serum_fattyacid serum_aminoacids 0.0186 0.00265 no no dn up up no 18:0/18:0-PE+blood L-Proline+blood 0 0.490196078 0 yes serum_phospholipids serum_aminoacids 0.00896 0.00265 up up no up up no 18:0/18:0-PS+blood L-Proline+blood -0.529323308 0 0 yes serum_phospholipids serum_aminoacids 0.00617 0.00265 no up no up up no 18:0/18:1-PE+blood L-Proline+blood 0 0.544117647 0 yes serum_phospholipids serum_aminoacids 0.00716 0.00265 up up no up up no 18:0/18:1-PG+blood L-Proline+blood 0 0.492647059 0 yes serum_phospholipids serum_aminoacids 0.000842 0.00265 no up no up up no 18:0/18:2-PI+blood L-Proline+blood -0.490225564 0 0 yes serum_phospholipids serum_aminoacids 0.179 0.00265 no no no up up no 18:0/20:4-PC+blood L-Proline+blood 0 -0.757352941 0 yes serum_phospholipids serum_aminoacids 0.454 0.00265 no no no up up no 18:0/20:5-PC+blood L-Proline+blood 0 -0.602941176 0 yes serum_phospholipids serum_aminoacids 0.17 0.00265 no no no up up no 18:0/22:6-PA+blood L-Proline+blood 0 -0.566176471 0 yes serum_phospholipids serum_aminoacids 0.22 0.00265 no no no up up no 18:0/22:6-PI+blood L-Proline+blood -0.533834586 0 0 yes serum_phospholipids serum_aminoacids 0.425 0.00265 no no no up up no 18:1/18:0-PE+blood L-Proline+blood 0 0.571078431 0 yes serum_phospholipids serum_aminoacids 1.39E-06 0.00265 up up no up up no 18:1/18:0-PS+blood L-Proline+blood -0.47518797 0 0 yes serum_phospholipids serum_aminoacids 0.193 0.00265 no no no up up no 18:1/18:2-PE+blood L-Proline+blood 0 0.585784314 0 yes serum_phospholipids serum_aminoacids 0.000293 0.00265 up up no up up no 18:1/20:4-PC+blood L-Proline+blood 0 -0.659313725 0 yes serum_phospholipids serum_aminoacids 0.582 0.00265 no no no up up no 18:1+blood L-Proline+blood -0.562406015 0 -0.468717949 yes yes serum_fattyacid serum_aminoacids 0.00202 0.00265 up no dn up up no 18:2-LPE+blood L-Proline+blood 0.458646617 0 0 yes serum_phospholipids serum_aminoacids 0.112 0.00265 no no no up up no 18:3-LPC+blood L-Proline+blood 0 0 0.405128205 yes serum_phospholipids serum_aminoacids 0.147 0.00265 no no no up up no 18:3/18:2-PC+blood L-Proline+blood -0.469172932 0 0 yes serum_phospholipids serum_aminoacids 0.0394 0.00265 no no up up up no 18:3n3+blood L-Proline+blood -0.526315789 0 0 yes serum_fattyacid serum_aminoacids 0.291 0.00265 no no no up up no 20:0/20:4-PE+blood L-Proline+blood 0 0.534313725 0 yes serum_phospholipids serum_aminoacids 0.00128 0.00265 up up no up up no 20:0+blood L-Proline+blood 0 -0.558823529 0 yes yes serum_fattyacid serum_aminoacids 0.000278 0.00265 dn no up up up no 20:1-LPE+blood L-Proline+blood 0 -0.656862745 0 yes serum_phospholipids serum_aminoacids 0.465 0.00265 no no no up up no 20:1/20:4-PE+blood L-Proline+blood -0.568421053 0 -0.496068376 yes serum_phospholipids serum_aminoacids 0.0042 0.00265 up up no up up no 20:2/18:1-PE+blood L-Proline+blood -0.551879699 0.578431373 -0.483076923 yes serum_phospholipids serum_aminoacids 0.00208 0.00265 up up no up up no 20:3/16:0-PC+blood L-Proline+blood 0 -0.651960784 0 yes serum_phospholipids serum_aminoacids 0.00405 0.00265 no up up up up no 20:3/18:0-PC+blood L-Proline+blood 0 -0.607843137 0 yes serum_phospholipids serum_aminoacids 0.296 0.00265 no no no up up no 20:3n6+blood L-Proline+blood 0 0 -0.491965812 yes serum_fattyacid serum_aminoacids 0.0884 0.00265 up no no up up no 20:4-LPE+blood L-Proline+blood 0 -0.681372549 0 yes serum_phospholipids serum_aminoacids 0.552 0.00265 no no no up up no 20:4n6+blood L-Proline+blood 0 -0.598039216 0 yes serum_fattyacid serum_aminoacids 0.133 0.00265 no no no up up no 20:5/18:0-PC+blood L-Proline+blood 0 -0.700980392 0 yes serum_phospholipids serum_aminoacids 3.97E-06 0.00265 no up up up up no 22:0/16:0-PE+blood L-Proline+blood 0 -0.644607843 0 yes serum_phospholipids serum_aminoacids 0.091 0.00265 no no up up up no 22:6n3+blood L-Proline+blood 0 -0.522058824 0 yes serum_fattyacid serum_aminoacids 0.792 0.00265 no no no up up no 24:0+blood L-Proline+blood -0.697744361 0 0 yes serum_fattyacid serum_aminoacids 0.034 0.00265 dn no up up up no AA+blood L-Proline+blood -0.517293233 0 0 yes serum_ARA serum_aminoacids 0.212 0.00265 no no no up up no Adipocytokine signaling pathway L-Proline+blood 0.714035088 0 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Alzheimer disease L-Proline+blood 0 0.523529412 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no AMPK signaling pathway L-Proline+blood 0.71754386 0 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Amyotrophic lateral sclerosis L-Proline+blood 0 0.5 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Bifidobacterium L-Proline+blood -0.555848102 0.56529747 0 acetate-producing yes Genus serum_aminoacids 0.105 0.00265 no dn no up up no Blautia L-Proline+blood -0.536842105 0 0 acetate-producing yes Genus serum_aminoacids 1.36E-05 0.00265 up dn dn up up no CA+blood L-Proline+blood 0.583678116 0 0 yes serum_bileacids serum_aminoacids 0.606 0.00265 no no no up up no Cardiac muscle contraction L-Proline+blood 0 0.532352941 0 yes kegg serum_aminoacids NA 0.00265 no no up up up no Cholinergic synapse L-Proline+blood 0 0 0.421538462 yes kegg serum_aminoacids NA 0.00265 no no no up up no Chronic myeloid leukemia L-Proline+blood 0.480701754 0 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Clostridium L-Proline+blood -0.492996205 0 0 yes Genus serum_aminoacids 0.925 0.00265 no no no up up no d18:0-16:0-SM+blood L-Proline+blood -0.490225564 0 0 yes serum_phospholipids serum_aminoacids 0.202 0.00265 no no no up up no d18:0-18:3-SM+blood L-Proline+blood -0.446616541 0 0 yes serum_phospholipids serum_aminoacids 0.0879 0.00265 no dn no up up no d18:1-14:0-SM+blood L-Proline+blood -0.538345865 0 0 yes serum_phospholipids serum_aminoacids 0.94 0.00265 no no no up up no d18:1-14:1-SM+blood L-Proline+blood -0.491729323 0 0 yes serum_phospholipids serum_aminoacids 0.0952 0.00265 no dn no up up no d18:1-16:0-SM+blood L-Proline+blood -0.448120301 0 0 yes serum_phospholipids serum_aminoacids 0.14 0.00265 no no no up up no d18:1-16:1-SM+blood L-Proline+blood -0.621052632 0 0 yes serum_phospholipids serum_aminoacids 0.2 0.00265 no no no up up no d18:1-20:0-SM+blood L-Proline+blood -0.541353383 0 0 yes serum_phospholipids serum_aminoacids 0.933 0.00265 no no no up up no d18:1-22:1-SM+blood L-Proline+blood -0.538345865 0 0 yes serum_phospholipids serum_aminoacids 0.222 0.00265 no no no up up no Diabetic cardiomyopathy L-Proline+blood 0 0.544117647 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Dorea L-Proline+blood 0 0.482843137 0 yes Genus serum_aminoacids 0.00362 0.00265 up no dn up up no Fc gamma R-mediated phagocytosis L-Proline+blood -0.471929825 0 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no GCA+blood L-Proline+blood 0 0.522058824 0 yes yes serum_bileacids serum_aminoacids 0.16 0.00265 no no no up up no GCDCA+blood L-Proline+blood 0 0.62745098 0 yes serum_bileacids serum_aminoacids 0.31 0.00265 no no no up up no GCDCA+stool L-Proline+blood 0 0.690909091 0 yes yes stool_bileacids serum_aminoacids 0.0471 0.00265 no dn no up up no HCA+blood L-Proline+blood 0.473946892 0 0.422197232 yes serum_bileacids serum_aminoacids 0.544 0.00265 no no no up up no HCA+stool L-Proline+blood -0.576923077 0 0 yes stool_bileacids serum_aminoacids 0.155 0.00265 no no no up up no Huntington disease L-Proline+blood 0 0.517647059 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no iso-LCA+blood L-Proline+blood 0.547892798 0 0.526040018 yes serum_bileacids serum_aminoacids 0.507 0.00265 no no no up up no Kaposi sarcoma-associated herpesvirus infection L-Proline+blood 0.578947368 0.547058824 0 yes kegg serum_aminoacids NA 0.00265 no no dn up up no L-2-Aminobutyric acid+blood L-Proline+blood 0 -0.507352941 0 yes yes serum_aminoacids serum_aminoacids 0.000328 0.00265 up up no up up no L-Alanine+blood L-Proline+blood 0.521804511 0 0 yes yes serum_aminoacids serum_aminoacids 0.00138 0.00265 up up no up up no L-Citrulline+blood L-Proline+blood 0.45112782 0 0 yes serum_aminoacids serum_aminoacids 0.534 0.00265 no no no up up no L-Glutamine+blood L-Proline+blood 0.603007519 0 0 yes serum_aminoacids serum_aminoacids 0.639 0.00265 no no no up up no L-Ornithine+blood L-Proline+blood 0.551879699 0 0.457094017 yes serum_aminoacids serum_aminoacids 0.175 0.00265 no no no up up no Legionellosis L-Proline+blood 0 0 -0.444615385 yes kegg serum_aminoacids NA 0.00265 no no no up up no Leishmaniasis L-Proline+blood 0 0 -0.420769231 yes kegg serum_aminoacids NA 0.00265 no no no up up no Lipid and atherosclerosis L-Proline+blood -0.545614035 0 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Longevity regulating pathway L-Proline+blood 0.615789474 0 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Longevity regulating pathway - multiple species L-Proline+blood -0.657894737 0 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no MAPK signaling pathway L-Proline+blood 0 -0.579411765 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Mitophagy - animal L-Proline+blood 0.526315789 0.670588235 -0.454615385 yes kegg serum_aminoacids NA 0.00265 no no no up up no mTOR signaling pathway L-Proline+blood 0 0 -0.428461538 yes kegg serum_aminoacids NA 0.00265 no no no up up no Olfactory transduction L-Proline+blood -0.524561404 0 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Oxidative phosphorylation L-Proline+blood 0 0.573529412 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Parabacteroides L-Proline+blood 0 -0.740196078 0 yes Genus serum_aminoacids 4.19E-05 0.00265 no up up up up no Parkinson disease L-Proline+blood 0 0.635294118 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Pathways of neurodegeneration - multiple diseases L-Proline+blood 0 0.635294118 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Peroxisome L-Proline+blood -0.456140351 0 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Phenylacetic acid+stool L-Proline+blood 0 -0.609090909 0 yes stool_cometabolism serum_aminoacids 0.785 0.00265 no no no up up no Prevotella L-Proline+blood 0 0 0.538137378 acetate-producing yes Genus serum_aminoacids 0.287 0.00265 no no no up up no Relaxin signaling pathway L-Proline+blood 0.480701754 0 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Roseburia L-Proline+blood 0 0.611894658 0 butyrate-producing yes Genus serum_aminoacids 0.495 0.00265 no no no up up no Ruminococcus L-Proline+blood 0 0.532188941 0 yes Genus serum_aminoacids 0.0679 0.00265 no no dn up up no Salmonella infection L-Proline+blood -0.456140351 0 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no Shigellosis L-Proline+blood 0.549122807 0.588235294 -0.456153846 yes kegg serum_aminoacids NA 0.00265 no no no up up no TCA+stool L-Proline+blood 0 0.663636364 0 yes stool_bileacids serum_aminoacids 0.458 0.00265 no no no up up no Ubiquitin mediated proteolysis L-Proline+blood 0.473684211 0.6 -0.471538462 yes kegg serum_aminoacids NA 0.00265 no no no up up no Vascular smooth muscle contraction L-Proline+blood 0 0.526470588 0 yes kegg serum_aminoacids NA 0.00265 no no no up up no 12-ketoDCA+blood L-Threonine+blood 0 0 -0.51656554 serum_bileacids serum_aminoacids 0.517 0.0538 no no no dn no up 14:0/16:0-PC+blood L-Threonine+blood 0 -0.607843137 0 serum_phospholipids serum_aminoacids 0.0358 0.0538 no up no dn no up 14:0/18:2-PC+blood L-Threonine+blood -0.44962406 -0.664215686 0 serum_phospholipids serum_aminoacids 0.102 0.0538 no up no dn no up 14:0+blood L-Threonine+blood -0.479699248 0 0 yes serum_fattyacid serum_aminoacids 0.00572 0.0538 up no dn dn no up 16:0/16:0-PI+blood L-Threonine+blood -0.496240602 0 -0.423589744 serum_phospholipids serum_aminoacids 0.358 0.0538 no no no dn no up 16:0/18:0-PS+blood L-Threonine+blood -0.55037594 0 0 serum_phospholipids serum_aminoacids 0.377 0.0538 no no no dn no up 16:0/20:4-PI+blood L-Threonine+blood -0.526315789 0 0 serum_phospholipids serum_aminoacids 0.558 0.0538 no no no dn no up 16:0+blood L-Threonine+blood 0 -0.50245098 0 yes serum_fattyacid serum_aminoacids 0.00876 0.0538 up no no dn no up 18:0-LPA+blood L-Threonine+blood 0 0.482843137 0 serum_phospholipids serum_aminoacids 0.0725 0.0538 no dn no dn no up 18:0/18:0-PS+blood L-Threonine+blood -0.593984962 0 0 serum_phospholipids serum_aminoacids 0.00617 0.0538 no up no dn no up 18:0/18:2-PI+blood L-Threonine+blood -0.505263158 0 0 serum_phospholipids serum_aminoacids 0.179 0.0538 no no no dn no up 18:0/22:6-PE+blood L-Threonine+blood -0.481203008 0 0 serum_phospholipids serum_aminoacids 0.00022 0.0538 up up no dn no up 18:0/22:6-PI+blood L-Threonine+blood -0.496240602 0 0 serum_phospholipids serum_aminoacids 0.425 0.0538 no no no dn no up 18:1/16:0-PI+blood L-Threonine+blood -0.45112782 0 0 serum_phospholipids serum_aminoacids 0.793 0.0538 no no no dn no up 18:1/18:2-PI+blood L-Threonine+blood 0 0.50245098 0 serum_phospholipids serum_aminoacids 0.0164 0.0538 dn no up dn no up 18:1/20:4-PC+blood L-Threonine+blood 0 0 0.411282051 serum_phospholipids serum_aminoacids 0.582 0.0538 no no no dn no up 20:0/20:4-PE+blood L-Threonine+blood -0.472180451 0 0 serum_phospholipids serum_aminoacids 0.00128 0.0538 up up no dn no up 20:1/20:4-PE+blood L-Threonine+blood -0.503759398 0 0 serum_phospholipids serum_aminoacids 0.0042 0.0538 up up no dn no up 20:2/18:1-PE+blood L-Threonine+blood -0.445112782 0 0 serum_phospholipids serum_aminoacids 0.00208 0.0538 up up no dn no up 20:4-LPA+blood L-Threonine+blood 0 0.485294118 0 serum_phospholipids serum_aminoacids 0.398 0.0538 no no no dn no up 20:4/18:0-PE+blood L-Threonine+blood -0.473684211 0 0 serum_phospholipids serum_aminoacids 0.000755 0.0538 up up no dn no up 22:1-LPA+blood L-Threonine+blood 0 0.5 0 serum_phospholipids serum_aminoacids 0.00373 0.0538 no up up dn no up 24:0+blood L-Threonine+blood -0.571428571 0 0 serum_fattyacid serum_aminoacids 0.034 0.0538 dn no up dn no up 4-hydroxybenzoic acid+stool L-Threonine+blood 0 0 0.54887218 stool_cometabolism serum_aminoacids 0.0536 0.0538 no dn no dn no up 8-HETE+blood L-Threonine+blood 0 0 0.504957265 serum_ARA serum_aminoacids 0.741 0.0538 no no no dn no up ACA+stool L-Threonine+blood 0 0 -0.446385084 stool_bileacids serum_aminoacids 0.417 0.0538 no no no dn no up Acetic acid+stool L-Threonine+blood 0 0.636363636 0 yes stool_scfa serum_aminoacids 0.0656 0.0538 dn no no dn no up Adipocytokine signaling pathway L-Threonine+blood 0.656140351 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Asthma L-Threonine+blood 0.49122807 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Autophagy - animal L-Threonine+blood 0 0 0.485384615 kegg serum_aminoacids NA 0.0538 no no no dn no up Bifidobacterium L-Threonine+blood -0.66265518 0 0 acetate-producing Genus serum_aminoacids 0.105 0.0538 no dn no dn no up Butyricimonas L-Threonine+blood 0 -0.667934488 0 butyrate-producing Genus serum_aminoacids 0.17 0.0538 no no no dn no up Cell cycle L-Threonine+blood -0.48245614 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Central carbon metabolism in cancer L-Threonine+blood -0.701754386 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Chemokine signaling pathway L-Threonine+blood 0 0 -0.429230769 kegg serum_aminoacids NA 0.0538 no no no dn no up Choline metabolism in cancer L-Threonine+blood 0 0 0.510769231 kegg serum_aminoacids NA 0.0538 no no no dn no up Cholinergic synapse L-Threonine+blood 0 0 0.472307692 kegg serum_aminoacids NA 0.0538 no no no dn no up Colorectal cancer L-Threonine+blood 0 -0.623529412 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Cystine+blood L-Threonine+blood 0.541353383 0 0 yes serum_aminoacids serum_aminoacids 0.00028 0.0538 up up no dn no up d18:1-14:0-SM+blood L-Threonine+blood -0.673684211 0 0 serum_phospholipids serum_aminoacids 0.94 0.0538 no no no dn no up d18:1-14:1-SM+blood L-Threonine+blood -0.580451128 0 0 serum_phospholipids serum_aminoacids 0.0952 0.0538 no dn no dn no up DHA+blood L-Threonine+blood -0.535338346 0 0 serum_ARA serum_aminoacids 0.872 0.0538 no no no dn no up DMG+blood L-Threonine+blood 0.460150376 0 0 serum_choline serum_aminoacids 0.909 0.0538 no no no dn no up Estrogen signaling pathway L-Threonine+blood -0.519298246 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Gemmiger L-Threonine+blood 0 -0.533171143 0 butyrate-producing Genus serum_aminoacids 0.595 0.0538 no no no dn no up Glioma L-Threonine+blood 0 0 0.426153846 kegg serum_aminoacids NA 0.0538 no no no dn no up Glutamatergic synapse L-Threonine+blood 0.477192982 0 0 kegg serum_aminoacids NA 0.0538 no up up dn no up Glycolysis / Gluconeogenesis L-Threonine+blood -0.505263158 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up HCA+blood L-Threonine+blood 0 -0.488533119 0 serum_bileacids serum_aminoacids 0.544 0.0538 no no no dn no up Hypotaurine+blood L-Threonine+blood 0 0 0.472136752 serum_aminoacids serum_aminoacids 0.933 0.0538 no no no dn no up Intestinal immune network for IgA production L-Threonine+blood 0.519298246 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Kaposi sarcoma-associated herpesvirus infection L-Threonine+blood 0.550877193 0 0 kegg serum_aminoacids NA 0.0538 no no dn dn no up L-Alanine+blood L-Threonine+blood 0.445112782 0 0 yes serum_aminoacids serum_aminoacids 0.00138 0.0538 up up no dn no up L-Arginine+blood L-Threonine+blood 0.557894737 0 0 serum_aminoacids serum_aminoacids 0.316 0.0538 no no no dn no up L-Asparagine+blood L-Threonine+blood 0.457142857 0.656862745 0.591111111 serum_aminoacids serum_aminoacids 0.784 0.0538 no no no dn no up L-Citrulline+blood L-Threonine+blood 0.497744361 0 0.405811966 serum_aminoacids serum_aminoacids 0.534 0.0538 no no no dn no up L-Glutamine+blood L-Threonine+blood 0.595488722 0 0 serum_aminoacids serum_aminoacids 0.639 0.0538 no no no dn no up L-Lysine+blood L-Threonine+blood 0 0.524509804 0 yes serum_aminoacids serum_aminoacids 0.0107 0.0538 no up no dn no up L-Methionine+blood L-Threonine+blood 0 0.681372549 0.466666667 serum_aminoacids serum_aminoacids 0.626 0.0538 no no no dn no up L-Ornithine+blood L-Threonine+blood 0.645112782 0 0 serum_aminoacids serum_aminoacids 0.175 0.0538 no no no dn no up L-Proline+blood L-Threonine+blood 0.578947368 0 0 yes serum_aminoacids serum_aminoacids 0.00265 0.0538 up up no dn no up Legionellosis L-Threonine+blood -0.60877193 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Leishmaniasis L-Threonine+blood -0.484210526 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Longevity regulating pathway - multiple species L-Threonine+blood -0.598245614 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Morphine addiction L-Threonine+blood 0.521052632 0 0 kegg serum_aminoacids NA 0.0538 no up up dn no up Non-small cell lung cancer L-Threonine+blood 0 0 0.405384615 kegg serum_aminoacids NA 0.0538 no no no dn no up Phosphatidylinositol signaling system L-Threonine+blood 0 0 0.432307692 kegg serum_aminoacids NA 0.0538 no no no dn no up PI3K-Akt signaling pathway L-Threonine+blood -0.471929825 0 0 yes kegg serum_aminoacids NA 0.0538 no up up dn no up Prevotella L-Threonine+blood 0 -0.54349042 0 acetate-producing Genus serum_aminoacids 0.287 0.0538 no no no dn no up Primary immunodeficiency L-Threonine+blood -0.724561404 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Ras signaling pathway L-Threonine+blood 0 0 0.416153846 yes kegg serum_aminoacids NA 0.0538 no up up dn no up RNA transport L-Threonine+blood -0.631578947 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Spliceosome L-Threonine+blood -0.512280702 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Th1 and Th2 cell differentiation L-Threonine+blood 0.561403509 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Th17 cell differentiation L-Threonine+blood 0.570175439 0 0 kegg serum_aminoacids NA 0.0538 no no no dn no up Vasopressin-regulated water reabsorption L-Threonine+blood 0 0 -0.407692308 kegg serum_aminoacids NA 0.0538 no no no dn no up 12-HEPE+blood L-Tryptophan+blood 0.457177049 -0.503856806 0 serum_ARA serum_aminoacids 0.312 0.164 no no no no no no 14:0/20:4-PC+blood L-Tryptophan+blood -0.47518797 0 0 serum_phospholipids serum_aminoacids 0.486 0.164 no no no no no no 16:0/16:1-PI+blood L-Tryptophan+blood 0 0 -0.408547009 serum_phospholipids serum_aminoacids 0.262 0.164 no no no no no no 16:0/18:0-PC+blood L-Tryptophan+blood 0 -0.541666667 0 serum_phospholipids serum_aminoacids 0.521 0.164 no no no no no no 16:0/18:3-PC+blood L-Tryptophan+blood -0.496240602 0 0 serum_phospholipids serum_aminoacids 0.00216 0.164 no up up no no no 16:0/20:4-PI+blood L-Tryptophan+blood 0 0 -0.531623932 serum_phospholipids serum_aminoacids 0.558 0.164 no no no no no no 16:0/22:0-PE+blood L-Tryptophan+blood 0 0 0.427008547 serum_phospholipids serum_aminoacids 0.00839 0.164 dn no up no no no 18:0-LPE+blood L-Tryptophan+blood 0 0 -0.478974359 serum_phospholipids serum_aminoacids 0.491 0.164 no no no no no no 18:0/18:1-PE+blood L-Tryptophan+blood -0.452631579 0 0 serum_phospholipids serum_aminoacids 0.00716 0.164 up up no no no no 18:0/20:3-PI+blood L-Tryptophan+blood 0.557894737 0 0 serum_phospholipids serum_aminoacids 0.377 0.164 no no no no no no 18:2-LPA+blood L-Tryptophan+blood 0 0.629901961 0 serum_phospholipids serum_aminoacids 0.00684 0.164 dn no up no no no 18:3/16:0-PE+blood L-Tryptophan+blood -0.530827068 0 0 serum_phospholipids serum_aminoacids 0.00149 0.164 up up no no no no 18:3/18:2-PC+blood L-Tryptophan+blood -0.642105263 0 0 serum_phospholipids serum_aminoacids 0.0394 0.164 no no up no no no 18:3n6+blood L-Tryptophan+blood -0.616541353 0 -0.556923077 serum_fattyacid serum_aminoacids 0.0463 0.164 up no dn no no no 20:0+blood L-Tryptophan+blood 0 -0.666666667 0 yes serum_fattyacid serum_aminoacids 0.000278 0.164 dn no up no no no 20:1-LPE+blood L-Tryptophan+blood 0 -0.534313725 0 serum_phospholipids serum_aminoacids 0.465 0.164 no no no no no no 20:2-LPE+blood L-Tryptophan+blood 0 -0.512254902 0 serum_phospholipids serum_aminoacids 0.177 0.164 no no no no no no 20:2/18:1-PE+blood L-Tryptophan+blood -0.452631579 0 0 serum_phospholipids serum_aminoacids 0.00208 0.164 up up no no no no 20:2/18:3-PE+blood L-Tryptophan+blood 0 -0.512254902 0 serum_phospholipids serum_aminoacids 0.0391 0.164 up up no no no no 20:4-LPC+blood L-Tryptophan+blood 0.535338346 0 0 serum_phospholipids serum_aminoacids 0.949 0.164 no no no no no no 20:4/16:0-PE+blood L-Tryptophan+blood 0 0 -0.453675214 serum_phospholipids serum_aminoacids 0.00529 0.164 no up up no no no AGE-RAGE signaling pathway in diabetic complications L-Tryptophan+blood 0.524561404 0 0 kegg serum_aminoacids NA 0.164 no no no no no no Betaine+blood L-Tryptophan+blood 0.472180451 0 0 serum_choline serum_aminoacids 0.857 0.164 no no no no no no Bifidobacterium L-Tryptophan+blood 0 0.567749953 0 acetate-producing Genus serum_aminoacids 0.105 0.164 no dn no no no no Blautia L-Tryptophan+blood 0 0.625 0 acetate-producing Genus serum_aminoacids 1.36E-05 0.164 up dn dn no no no Breast cancer L-Tryptophan+blood 0.456140351 0 0 kegg serum_aminoacids NA 0.164 no no no no no no capric acid C6+blood L-Tryptophan+blood 0 0 0.412649573 serum_scfa serum_aminoacids 0.433 0.164 no no no no no no Carbon metabolism L-Tryptophan+blood -0.473684211 0 0 kegg serum_aminoacids NA 0.164 no no no no no no CDCA+blood L-Tryptophan+blood 0 0 -0.418119658 serum_bileacids serum_aminoacids 0.506 0.164 no no no no no no Choline metabolism in cancer L-Tryptophan+blood 0.464912281 0 0 kegg serum_aminoacids NA 0.164 no no no no no no Choline+blood L-Tryptophan+blood 0.545864662 0.492647059 0 serum_choline serum_aminoacids 0.0395 0.164 no up no no no no Cholinergic synapse L-Tryptophan+blood 0 -0.626470588 0 kegg serum_aminoacids NA 0.164 no no no no no no Coprococcus L-Tryptophan+blood 0 0.5 0 butyrate-producing Genus serum_aminoacids 0.612 0.164 no no no no no no Creatinine+blood L-Tryptophan+blood 0.763909774 0.735294118 0 serum_choline serum_aminoacids 0.437 0.164 no no no no no no Cysteine+blood L-Tryptophan+blood 0 0 0.429059829 yes serum_aminoacids serum_aminoacids 1.81E-07 0.164 dn up up no no no Cystine+blood L-Tryptophan+blood 0 0.539215686 0 yes serum_aminoacids serum_aminoacids 0.00028 0.164 up up no no no no d18:1-14:1-SM+blood L-Tryptophan+blood -0.487218045 0 -0.526837607 serum_phospholipids serum_aminoacids 0.0952 0.164 no dn no no no no d18:1-16:1-SM+blood L-Tryptophan+blood 0 0 -0.434529915 serum_phospholipids serum_aminoacids 0.2 0.164 no no no no no no decanoic acid C10+blood L-Tryptophan+blood 0 0 0.452991453 serum_mcfa serum_aminoacids 6.64E-11 0.164 dn dn no no no no DL-methionine sulfoxide+blood L-Tryptophan+blood 0 0.595588235 0 serum_aminoacids serum_aminoacids 0.302 0.164 no no no no no no DMG+blood L-Tryptophan+blood 0 0.531862745 0.415384615 serum_choline serum_aminoacids 0.909 0.164 no no no no no no Dorea L-Tryptophan+blood 0 0.495098039 0 Genus serum_aminoacids 0.00362 0.164 up no dn no no no Endocrine resistance L-Tryptophan+blood 0.542105263 0 0 kegg serum_aminoacids NA 0.164 no no no no no no ErbB signaling pathway L-Tryptophan+blood 0.487719298 0 0 kegg serum_aminoacids NA 0.164 no no no no no no Ethanolamine+blood L-Tryptophan+blood 0 0 0.506324786 serum_aminoacids serum_aminoacids 0.122 0.164 up no no no no no Fc epsilon RI signaling pathway L-Tryptophan+blood 0.571929825 0 0 kegg serum_aminoacids NA 0.164 no no no no no no GCDCA+stool L-Tryptophan+blood 0 0.690909091 0 yes stool_bileacids serum_aminoacids 0.0471 0.164 no dn no no no no GDCA+stool L-Tryptophan+blood 0 0.619591585 0 stool_bileacids serum_aminoacids 0.656 0.164 no no no no no no "Growth hormone synthesis, secretion and action" L-Tryptophan+blood 0.585964912 0 0 kegg serum_aminoacids NA 0.164 no no no no no no HDCA+blood L-Tryptophan+blood 0.460374502 0 0 serum_bileacids serum_aminoacids 0.483 0.164 no no no no no no heptanoic acid C7+blood L-Tryptophan+blood 0 0 0.616410256 serum_mcfa serum_aminoacids 8.27E-11 0.164 dn dn no no no no Human T-cell leukemia virus 1 infection L-Tryptophan+blood -0.470175439 0 0 kegg serum_aminoacids NA 0.164 no no no no no no Hypotaurine+blood L-Tryptophan+blood 0 0 0.426324786 serum_aminoacids serum_aminoacids 0.933 0.164 no no no no no no L-Alanine+blood L-Tryptophan+blood 0 0.492647059 0 yes serum_aminoacids serum_aminoacids 0.00138 0.164 up up no no no no L-Arginine+blood L-Tryptophan+blood 0.491729323 0 0 serum_aminoacids serum_aminoacids 0.316 0.164 no no no no no no L-Asparagine+blood L-Tryptophan+blood 0 0 0.734700855 serum_aminoacids serum_aminoacids 0.784 0.164 no no no no no no L-Citrulline+blood L-Tryptophan+blood 0 0 0.458461538 serum_aminoacids serum_aminoacids 0.534 0.164 no no no no no no L-Glutamic acid+blood L-Tryptophan+blood 0.639097744 0.612745098 0 yes serum_aminoacids serum_aminoacids 6.20E-05 0.164 up up no no no no L-Glutamine+blood L-Tryptophan+blood 0 0.524509804 0.494700855 serum_aminoacids serum_aminoacids 0.639 0.164 no no no no no no L-Histidine+blood L-Tryptophan+blood 0.587969925 0 0.598632479 serum_aminoacids serum_aminoacids 0.109 0.164 no no no no no no L-Isoleucine+blood L-Tryptophan+blood 0.618045113 0.718137255 0.585641026 yes serum_aminoacids serum_aminoacids 5.47E-06 0.164 up up no no no no L-Leucine+blood L-Tryptophan+blood 0 0.536764706 0.526153846 yes serum_aminoacids serum_aminoacids 3.22E-05 0.164 up up no no no no L-Lysine+blood L-Tryptophan+blood 0.783458647 0.56372549 0.461196581 yes serum_aminoacids serum_aminoacids 0.0107 0.164 no up no no no no L-Methionine+blood L-Tryptophan+blood 0.822556391 0.68872549 0.771623932 serum_aminoacids serum_aminoacids 0.626 0.164 no no no no no no L-Ornithine+blood L-Tryptophan+blood 0 0 0.422222222 serum_aminoacids serum_aminoacids 0.175 0.164 no no no no no no L-Phenylalanine+blood L-Tryptophan+blood 0.809022556 0.803921569 0 yes serum_aminoacids serum_aminoacids 0.0103 0.164 up up no no no no L-Phenylalanine+stool L-Tryptophan+blood 0 0 0.669172932 stool_cometabolism serum_aminoacids 0.398 0.164 no no no no no no L-Proline+blood L-Tryptophan+blood 0 0.676470588 0 yes serum_aminoacids serum_aminoacids 0.00265 0.164 up up no no no no L-Tryptophan+stool L-Tryptophan+blood 0 0 0.511278195 stool_cometabolism serum_aminoacids 0.557 0.164 no no no no no no L-Tyrosine+stool L-Tryptophan+blood 0 0 0.693233083 stool_cometabolism serum_aminoacids 0.44 0.164 no no no no no no Leishmaniasis L-Tryptophan+blood -0.556140351 0 0 kegg serum_aminoacids NA 0.164 no no no no no no Long-term depression L-Tryptophan+blood 0 0 -0.412307692 kegg serum_aminoacids NA 0.164 no no no no no no Non-small cell lung cancer L-Tryptophan+blood 0.492982456 0 0 kegg serum_aminoacids NA 0.164 no no no no no no Parabacteroides L-Tryptophan+blood 0 -0.49754902 0 Genus serum_aminoacids 4.19E-05 0.164 no up up no no no Phospholipase D signaling pathway L-Tryptophan+blood 0.663157895 0 0 kegg serum_aminoacids NA 0.164 no up up no no no Prolactin signaling pathway L-Tryptophan+blood 0.594736842 0 0 kegg serum_aminoacids NA 0.164 no no no no no no TCA+stool L-Tryptophan+blood -0.602476498 0 0 stool_bileacids serum_aminoacids 0.458 0.164 no no no no no no 4-hydroxybenzoic acid+stool L-Tryptophan+stool 0 0.622377622 0 stool_cometabolism stool_cometabolism 0.0536 0.557 no dn no no no no ACA+stool L-Tryptophan+stool 0 -0.650443636 0 stool_bileacids stool_cometabolism 0.417 0.557 no no no no no no Allograft rejection L-Tryptophan+stool 0 0 -0.594579334 kegg stool_cometabolism NA 0.557 no no no no no no Antigen processing and presentation L-Tryptophan+stool 0 0 -0.529079616 kegg stool_cometabolism NA 0.557 no no no no no no Apelin signaling pathway L-Tryptophan+stool -0.547987616 0 0 kegg stool_cometabolism NA 0.557 no no no no no no Autoimmune thyroid disease L-Tryptophan+stool 0 0 -0.594579334 kegg stool_cometabolism NA 0.557 no no no no no no Axon guidance L-Tryptophan+stool 0 0 -0.437605872 kegg stool_cometabolism NA 0.557 no up up no no no Butyric acid+stool L-Tryptophan+stool -0.583075335 0 0 yes stool_scfa stool_cometabolism 0.102 0.557 dn no no no no no Butyricicoccus L-Tryptophan+stool 0 0 -0.525161207 butyrate-producing Genus stool_cometabolism 0.852 0.557 no no no no no no CA+stool L-Tryptophan+stool 0 0 -0.472332016 stool_bileacids stool_cometabolism 0.827 0.557 no no no no no no CDCA+stool L-Tryptophan+stool 0 0 -0.552371542 stool_bileacids stool_cometabolism 0.663 0.557 no no no no no no Cell adhesion molecules L-Tryptophan+stool 0 0 -0.596837945 kegg stool_cometabolism NA 0.557 no no no no no no Cellular senescence L-Tryptophan+stool 0 0 -0.593450028 kegg stool_cometabolism NA 0.557 no no no no no no Coronavirus disease - COVID-19 L-Tryptophan+stool -0.576883385 0 0 kegg stool_cometabolism NA 0.557 no no no no no no DCA+stool L-Tryptophan+stool -0.574819401 -0.664335664 0 stool_bileacids stool_cometabolism 0.195 0.557 no no no no no no EGFR tyrosine kinase inhibitor resistance L-Tryptophan+stool -0.484004128 0 0 kegg stool_cometabolism NA 0.557 no no no no no no Endocytosis L-Tryptophan+stool 0 0 -0.587803501 kegg stool_cometabolism NA 0.557 no no no no no no Epstein-Barr virus infection L-Tryptophan+stool 0 0 -0.555053642 kegg stool_cometabolism NA 0.557 no no no no no no Faecalibacterium L-Tryptophan+stool 0 0 -0.428289032 butyrate-producing Genus stool_cometabolism 0.0039 0.557 no dn dn no no no Gemmiger L-Tryptophan+stool -0.54723807 0 0 butyrate-producing Genus stool_cometabolism 0.595 0.557 no no no no no no Graft-versus-host disease L-Tryptophan+stool 0 0 -0.603613778 kegg stool_cometabolism NA 0.557 no no no no no no GUDCA+stool L-Tryptophan+stool 0.565668221 0 0 yes stool_bileacids stool_cometabolism 0.0085 0.557 no dn no no no no Herpes simplex virus 1 infection L-Tryptophan+stool 0 0 -0.470355731 kegg stool_cometabolism NA 0.557 no no no no no no Human cytomegalovirus infection L-Tryptophan+stool 0 0 -0.543760587 kegg stool_cometabolism NA 0.557 no no dn no no no Human immunodeficiency virus 1 infection L-Tryptophan+stool 0 0 -0.533596838 kegg stool_cometabolism NA 0.557 no no no no no no Human papillomavirus infection L-Tryptophan+stool 0 0 -0.523433089 kegg stool_cometabolism NA 0.557 no no no no no no Human T-cell leukemia virus 1 infection L-Tryptophan+stool 0 0 -0.511010728 kegg stool_cometabolism NA 0.557 no no no no no no Indole-3-Acetic acid+stool L-Tryptophan+stool 0.622291022 0 0.664031621 stool_cometabolism stool_cometabolism 0.304 0.557 no no no no no no Influenza A L-Tryptophan+stool 0.494324045 0 0 kegg stool_cometabolism NA 0.557 no no no no no no Insulin signaling pathway L-Tryptophan+stool -0.50877193 0 0 kegg stool_cometabolism NA 0.557 no no no no no no iso-DCA+stool L-Tryptophan+stool -0.484004128 0 0 stool_bileacids stool_cometabolism 0.155 0.557 no no no no no no Isobutyric acid+stool L-Tryptophan+stool 0 0 0.640316206 stool_scfa stool_cometabolism 0.408 0.557 no no no no no no Isovaleric acid+stool L-Tryptophan+stool 0 0 0.602766798 stool_scfa stool_cometabolism 0.343 0.557 no no no no no no L-Phenylalanine+stool L-Tryptophan+stool 0.909184727 0.888111888 0.918972332 stool_cometabolism stool_cometabolism 0.398 0.557 no no no no no no mTOR signaling pathway L-Tryptophan+stool -0.583075335 0 0 kegg stool_cometabolism NA 0.557 no no no no no no Natural killer cell mediated cytotoxicity L-Tryptophan+stool 0 0 -0.558441558 kegg stool_cometabolism NA 0.557 no no no no no no Neutrophil extracellular trap formation L-Tryptophan+stool 0.583075335 0 0 kegg stool_cometabolism NA 0.557 no no no no no no Pathogenic Escherichia coli infection L-Tryptophan+stool 0.492260062 0 0 kegg stool_cometabolism NA 0.557 no no no no no no Phagosome L-Tryptophan+stool 0 0 -0.514398645 kegg stool_cometabolism NA 0.557 no no no no no no Phospholipase D signaling pathway L-Tryptophan+stool 0.486068111 0 0 kegg stool_cometabolism NA 0.557 no up up no no no Prevotella L-Tryptophan+stool -0.538778043 0 0 acetate-producing Genus stool_cometabolism 0.287 0.557 no no no no no no Purine metabolism L-Tryptophan+stool -0.533539732 0 0 kegg stool_cometabolism NA 0.557 no no no no no no Renal cell carcinoma L-Tryptophan+stool 0 0.627272727 0 kegg stool_cometabolism NA 0.557 no no no no no no Ribosome L-Tryptophan+stool -0.55624355 0 0 kegg stool_cometabolism NA 0.557 no no no no no no Staphylococcus aureus infection L-Tryptophan+stool 0.545923633 0 0 kegg stool_cometabolism NA 0.557 up no no no no no Tuberculosis L-Tryptophan+stool 0.554179567 0 0 kegg stool_cometabolism NA 0.557 no no dn no no no Type I diabetes mellitus L-Tryptophan+stool 0 0 -0.593450028 kegg stool_cometabolism NA 0.557 no no no no no no Viral carcinogenesis L-Tryptophan+stool 0 0 -0.559570864 kegg stool_cometabolism NA 0.557 no no no no no no Viral myocarditis L-Tryptophan+stool 0 0 -0.57312253 kegg stool_cometabolism NA 0.557 no no no no no no Yersinia infection L-Tryptophan+stool 0.481940144 0 0 kegg stool_cometabolism NA 0.557 no no no no no no ¦Ø-MCA+stool L-Tryptophan+stool 0 -0.616041759 0 stool_bileacids stool_cometabolism 0.919 0.557 no no no no no no 16:0/16:0-PC+blood L-Tryptophan+urine 0.644607843 0 0 serum_phospholipids urine_cometabolism 0.00079 0.226 no up up no no no 16:0/18:0-PS+blood L-Tryptophan+urine -0.512254902 0 0 serum_phospholipids urine_cometabolism 0.377 0.226 no no no no no no 16:0/18:1-PC+blood L-Tryptophan+urine 0.735294118 0 0 serum_phospholipids urine_cometabolism 6.15E-07 0.226 up up up no no no 16:0/18:2-PC+blood L-Tryptophan+urine 0.68872549 0 0 serum_phospholipids urine_cometabolism 3.24E-06 0.226 no up up no no no 16:0/18:2-PI+blood L-Tryptophan+urine -0.485294118 0 0 serum_phospholipids urine_cometabolism 0.269 0.226 no no no no no no 16:0/20:3-PC+blood L-Tryptophan+urine 0.693627451 0 0 serum_phospholipids urine_cometabolism 5.43E-06 0.226 no up up no no no 16:0/20:4-PC+blood L-Tryptophan+urine 0.593137255 0 0 serum_phospholipids urine_cometabolism 0.0262 0.226 no up no no no no 16:0/22:6-PE+blood L-Tryptophan+urine -0.517156863 0 0 serum_phospholipids urine_cometabolism 0.000934 0.226 up up no no no no 16:1/16:0-PC+blood L-Tryptophan+urine 0.485294118 -0.604395604 0 serum_phospholipids urine_cometabolism 0.0215 0.226 no up up no no no 18:0-LPE+blood L-Tryptophan+urine -0.678921569 0 0 serum_phospholipids urine_cometabolism 0.491 0.226 no no no no no no 18:0/16:0-PC+blood L-Tryptophan+urine 0.723039216 0 0 serum_phospholipids urine_cometabolism 9.64E-07 0.226 up up up no no no 18:0/18:1-PE+blood L-Tryptophan+urine -0.541666667 0 0 serum_phospholipids urine_cometabolism 0.00716 0.226 up up no no no no 18:0/18:2-PC+blood L-Tryptophan+urine 0.605392157 0 0 serum_phospholipids urine_cometabolism 1.74E-06 0.226 no up up no no no 18:0/20:4-PC+blood L-Tryptophan+urine 0.68627451 0 0 serum_phospholipids urine_cometabolism 0.454 0.226 no no no no no no 18:0/22:6-PE+blood L-Tryptophan+urine -0.531862745 0 0 serum_phospholipids urine_cometabolism 0.00022 0.226 up up no no no no 18:1-LPC+blood L-Tryptophan+urine 0.492647059 0 0 serum_phospholipids urine_cometabolism 0.179 0.226 no no no no no no 18:1/16:0-PC+blood L-Tryptophan+urine 0.693627451 0 0 serum_phospholipids urine_cometabolism 2.43E-05 0.226 no up up no no no 18:1/18:0-PC+blood L-Tryptophan+urine 0.656862745 0 0 serum_phospholipids urine_cometabolism 1.83E-06 0.226 no up up no no no 18:1/18:1-PC+blood L-Tryptophan+urine 0.781862745 0 0 serum_phospholipids urine_cometabolism 1.34E-05 0.226 no up up no no no 18:1/18:1-PE+blood L-Tryptophan+urine -0.625 0 0 serum_phospholipids urine_cometabolism 1.03E-05 0.226 up up no no no no 18:1/20:4-PC+blood L-Tryptophan+urine 0.56372549 0 0 serum_phospholipids urine_cometabolism 0.582 0.226 no no no no no no 18:1+blood L-Tryptophan+urine 0 0 -0.446753247 yes serum_fattyacid urine_cometabolism 0.00202 0.226 up no dn no no no 18:2/16:0-PC+blood L-Tryptophan+urine 0.610294118 0 0 serum_phospholipids urine_cometabolism 8.67E-05 0.226 no up up no no no 18:2/18:2-PC+blood L-Tryptophan+urine 0.482843137 0 0 serum_phospholipids urine_cometabolism 1.98E-05 0.226 dn up up no no no 18:2/20:4-PC+blood L-Tryptophan+urine 0.575980392 0 0 serum_phospholipids urine_cometabolism 0.0145 0.226 no no up no no no 2-hydroxyhippuric acid+urine L-Tryptophan+urine -0.50075188 -0.51754386 -0.44957265 urine_cometabolism urine_cometabolism 0.215 0.226 no no no no no no 2-hydroxyphenylacetic acid+urine L-Tryptophan+urine 0 0 -0.455726496 urine_cometabolism urine_cometabolism 0.763 0.226 no no no no no no 20:0+blood L-Tryptophan+urine 0.566176471 0 0 yes serum_fattyacid urine_cometabolism 0.000278 0.226 dn no up no no no 20:3/16:0-PC+blood L-Tryptophan+urine 0.629901961 0 0 serum_phospholipids urine_cometabolism 0.00405 0.226 no up up no no no 20:3/18:0-PC+blood L-Tryptophan+urine 0 0 -0.5 serum_phospholipids urine_cometabolism 0.296 0.226 no no no no no no 22:6n3+blood L-Tryptophan+urine 0 0 -0.485714286 serum_fattyacid urine_cometabolism 0.792 0.226 no no no no no no 3-Hydroxy-L-kynurenine+urine L-Tryptophan+urine 0.642105263 0.675438596 0.489230769 urine_cometabolism urine_cometabolism 0.401 0.226 no no no no no no Anaerostipes L-Tryptophan+urine 0 0.506337545 0 butyrate-producing Genus urine_cometabolism 0.568 0.226 no no no no no no Apelin signaling pathway L-Tryptophan+urine 0 0 0.407692308 kegg urine_cometabolism NA 0.226 no no no no no no Clostridium L-Tryptophan+urine -0.527284967 0 0 Genus urine_cometabolism 0.925 0.226 no no no no no no Collinsella L-Tryptophan+urine -0.563253651 0 0 Genus urine_cometabolism 0.128 0.226 no no no no no no Cytosolic DNA-sensing pathway L-Tryptophan+urine 0.503508772 0 0 kegg urine_cometabolism NA 0.226 no no no no no no DL-methionine sulfoxide+blood L-Tryptophan+urine -0.541666667 0 0 serum_aminoacids urine_cometabolism 0.302 0.226 no no no no no no EGFR tyrosine kinase inhibitor resistance L-Tryptophan+urine 0 0 0.41 kegg urine_cometabolism NA 0.226 no no no no no no Fluid shear stress and atherosclerosis L-Tryptophan+urine 0 0 -0.427692308 kegg urine_cometabolism NA 0.226 no no no no no no Glucagon signaling pathway L-Tryptophan+urine 0 0 0.473076923 kegg urine_cometabolism NA 0.226 no no no no no no Glycine+blood L-Tryptophan+urine 0 -0.675824176 0 serum_aminoacids urine_cometabolism 0.00408 0.226 dn no up no no no Homovanillic acid+urine L-Tryptophan+urine -0.572932331 0 0 urine_cometabolism urine_cometabolism 0.45 0.226 no no no no no no Indole-3-Acetic acid+urine L-Tryptophan+urine 0 -0.49122807 0 urine_cometabolism urine_cometabolism 0.657 0.226 no no no no no no iso-DCA+blood L-Tryptophan+urine 0.612745098 0 0 serum_bileacids urine_cometabolism 0.38 0.226 no no no no no no L-Phenylalanine+urine L-Tryptophan+urine 0.715789474 0.840350877 0.781880342 urine_cometabolism urine_cometabolism 0.0908 0.226 no up no no no no L-Threonine+blood L-Tryptophan+urine 0 -0.593406593 0 serum_aminoacids urine_cometabolism 0.0538 0.226 dn no up no no no Lachnospira L-Tryptophan+urine -0.457142857 0 0 butyrate-producing Genus urine_cometabolism 0.279 0.226 no no no no no no Lysosome L-Tryptophan+urine 0 0 -0.434615385 kegg urine_cometabolism NA 0.226 no no no no no no mRNA surveillance pathway L-Tryptophan+urine 0 0 0.424615385 kegg urine_cometabolism NA 0.226 no no no no no no MUFA%+blood L-Tryptophan+urine 0 -0.692307692 0 serum_fattyacid urine_cometabolism 0.00142 0.226 up no dn no no no n3+blood L-Tryptophan+urine 0 0 -0.44025974 serum_fattyacid urine_cometabolism 0.806 0.226 no no no no no no Necroptosis L-Tryptophan+urine 0 0.514035088 0 kegg urine_cometabolism NA 0.226 no no no no no no PI3K-Akt signaling pathway L-Tryptophan+urine 0 0 0.43 yes kegg urine_cometabolism NA 0.226 no up up no no no PUFA%+blood L-Tryptophan+urine 0.647058824 -0.681318681 0 serum_fattyacid urine_cometabolism 0.0013 0.226 dn no up no no no Pyramidobacter L-Tryptophan+urine 0 0 0.428768601 Genus urine_cometabolism 0.45 0.226 no no no no no no RNA transport L-Tryptophan+urine 0 0 0.441538462 kegg urine_cometabolism NA 0.226 no no no no no no SFA%+blood L-Tryptophan+urine 0.625 -0.648351648 0 serum_fattyacid urine_cometabolism 0.0236 0.226 no up no no no no T cell receptor signaling pathway L-Tryptophan+urine 0 0 0.503846154 kegg urine_cometabolism NA 0.226 no no no no no no TCA+stool L-Tryptophan+urine 0 0 -0.488132095 stool_bileacids urine_cometabolism 0.458 0.226 no no no no no no TMAO+blood L-Tryptophan+urine 0 -0.565934066 0 serum_choline urine_cometabolism 0.00706 0.226 up up no no no no TUDCA+blood L-Tryptophan+urine -0.550899665 0 0 yes serum_bileacids urine_cometabolism 0.0282 0.226 no no dn no no no TXB2+blood L-Tryptophan+urine 0 -0.767967522 0 yes serum_ARA urine_cometabolism 0.0644 0.226 dn no no no no no UFA%+blood L-Tryptophan+urine 0.568627451 -0.752747253 0 serum_fattyacid urine_cometabolism 0.0236 0.226 no dn no no no no 11-HETE+blood L-Tyrosine+blood 0 0.533426676 0 yes serum_ARA serum_aminoacids 0.464 0.00913 no no no up up no 12-HEPE+blood L-Tyrosine+blood 0.522488056 -0.490684079 0 yes serum_ARA serum_aminoacids 0.312 0.00913 no no no up up no 15-HETE+blood L-Tyrosine+blood 0 0 -0.423215221 yes serum_ARA serum_aminoacids 0.819 0.00913 no no no up up no 16:0/16:0-PI+blood L-Tyrosine+blood 0 0.492647059 0 yes serum_phospholipids serum_aminoacids 0.358 0.00913 no no no up up no 16:0/16:1-PC+blood L-Tyrosine+blood 0 0.49754902 0 yes serum_phospholipids serum_aminoacids 0.00283 0.00913 up up no up up no 16:0/16:1-PI+blood L-Tyrosine+blood 0 0.556372549 0 yes serum_phospholipids serum_aminoacids 0.262 0.00913 no no no up up no 16:1/18:2-PG+blood L-Tyrosine+blood 0.445112782 0 0 yes serum_phospholipids serum_aminoacids 1.40E-08 0.00913 no up up up up no 18:0-LPE+blood L-Tyrosine+blood 0 0 -0.427692308 yes serum_phospholipids serum_aminoacids 0.491 0.00913 no no no up up no 18:0/18:0-PE+blood L-Tyrosine+blood -0.527819549 0 0 yes serum_phospholipids serum_aminoacids 0.00896 0.00913 up up no up up no 18:0/18:1-PE+blood L-Tyrosine+blood -0.523308271 0 0 yes serum_phospholipids serum_aminoacids 0.00716 0.00913 up up no up up no 18:0/20:3-PI+blood L-Tyrosine+blood 0.667669173 0 0 yes serum_phospholipids serum_aminoacids 0.377 0.00913 no no no up up no 18:0/20:4-PC+blood L-Tyrosine+blood 0 -0.541666667 0 yes serum_phospholipids serum_aminoacids 0.454 0.00913 no no no up up no 18:0/20:4-PI+blood L-Tyrosine+blood 0.478195489 0 0 yes serum_phospholipids serum_aminoacids 0.167 0.00913 no no no up up no 18:0/20:5-PC+blood L-Tyrosine+blood 0 -0.495098039 0 yes serum_phospholipids serum_aminoacids 0.17 0.00913 no no no up up no 18:1-LPC+blood L-Tyrosine+blood 0 0 -0.473504274 yes serum_phospholipids serum_aminoacids 0.179 0.00913 no no no up up no 18:1/16:0-PE+blood L-Tyrosine+blood -0.457142857 0 0 yes serum_phospholipids serum_aminoacids 0.000182 0.00913 up up no up up no 18:1/18:2-PE+blood L-Tyrosine+blood 0 0 -0.442051282 yes serum_phospholipids serum_aminoacids 0.000293 0.00913 up up no up up no 18:2-LPE+blood L-Tyrosine+blood 0 0 -0.471452991 yes serum_phospholipids serum_aminoacids 0.112 0.00913 no no no up up no 18:3/16:0-PE+blood L-Tyrosine+blood -0.461654135 0 0 yes serum_phospholipids serum_aminoacids 0.00149 0.00913 up up no up up no 18:3n6+blood L-Tyrosine+blood -0.615037594 0 0 yes serum_fattyacid serum_aminoacids 0.0463 0.00913 up no dn up up no 20:0/20:5-PC+blood L-Tyrosine+blood 0.487218045 0 0 yes serum_phospholipids serum_aminoacids 0.882 0.00913 no no no up up no 20:0+blood L-Tyrosine+blood 0 -0.536764706 0 yes yes serum_fattyacid serum_aminoacids 0.000278 0.00913 dn no up up up no 20:1-LPE+blood L-Tyrosine+blood 0 -0.571078431 0 yes serum_phospholipids serum_aminoacids 0.465 0.00913 no no no up up no 20:2-LPC+blood L-Tyrosine+blood 0.64962406 0 0 yes serum_phospholipids serum_aminoacids 0.119 0.00913 no no up up up no 20:3/18:0-PI+blood L-Tyrosine+blood 0.505263158 0 0 yes serum_phospholipids serum_aminoacids 0.289 0.00913 no no no up up no 20:3n6+blood L-Tyrosine+blood 0 0.56372549 0 yes serum_fattyacid serum_aminoacids 0.0884 0.00913 up no no up up no 20:4-LPC+blood L-Tyrosine+blood 0 -0.490196078 0 yes serum_phospholipids serum_aminoacids 0.949 0.00913 no no no up up no 20:4-LPE+blood L-Tyrosine+blood 0 -0.558823529 0 yes serum_phospholipids serum_aminoacids 0.552 0.00913 no no no up up no 20:4n6+blood L-Tyrosine+blood 0 -0.487745098 0 yes serum_fattyacid serum_aminoacids 0.133 0.00913 no no no up up no Adrenergic signaling in cardiomyocytes L-Tyrosine+blood 0.559649123 0 0 yes kegg serum_aminoacids NA 0.00913 no no up up up no Alzheimer disease L-Tyrosine+blood 0.466666667 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Apoptosis L-Tyrosine+blood -0.48245614 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Arrhythmogenic right ventricular cardiomyopathy L-Tyrosine+blood -0.519298246 0 0 yes kegg serum_aminoacids NA 0.00913 no up up up up no Asthma L-Tyrosine+blood 0 0 -0.519230769 yes kegg serum_aminoacids NA 0.00913 no no no up up no Bifidobacterium L-Tyrosine+blood 0 0.605763449 0 acetate-producing yes Genus serum_aminoacids 0.105 0.00913 no dn no up up no Biosynthesis of amino acids L-Tyrosine+blood -0.584210526 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Blautia L-Tyrosine+blood 0 0.553921569 0 acetate-producing yes Genus serum_aminoacids 1.36E-05 0.00913 up dn dn up up no Butyricimonas L-Tyrosine+blood 0.464185739 0 0 butyrate-producing yes Genus serum_aminoacids 0.17 0.00913 no no no up up no CA+stool L-Tyrosine+blood 0 0.709090909 0 yes stool_bileacids serum_aminoacids 0.827 0.00913 no no no up up no Calcium signaling pathway L-Tyrosine+blood 0.494736842 0 0 yes kegg serum_aminoacids NA 0.00913 no up up up up no cAMP signaling pathway L-Tyrosine+blood 0.519298246 0 0 yes yes kegg serum_aminoacids NA 0.00913 no up up up up no Carbon metabolism L-Tyrosine+blood -0.633333333 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no CDCA+stool L-Tyrosine+blood 0 0.809090909 0 yes stool_bileacids serum_aminoacids 0.663 0.00913 no no no up up no Cell adhesion molecules L-Tyrosine+blood 0 0 -0.479230769 yes kegg serum_aminoacids NA 0.00913 no no no up up no cGMP-PKG signaling pathway L-Tyrosine+blood 0.461403509 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Chemical carcinogenesis - receptor activation L-Tyrosine+blood 0 -0.55 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Choline metabolism in cancer L-Tyrosine+blood 0.489473684 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Choline+blood L-Tyrosine+blood 0.523308271 0 0.45025641 yes serum_choline serum_aminoacids 0.0395 0.00913 no up no up up no Cholinergic synapse L-Tyrosine+blood 0 -0.582352941 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Coprococcus L-Tyrosine+blood 0 0.490196078 0 butyrate-producing yes Genus serum_aminoacids 0.612 0.00913 no no no up up no Creatinine+blood L-Tyrosine+blood 0.589473684 0 0 yes serum_choline serum_aminoacids 0.437 0.00913 no no no up up no Cysteine+blood L-Tyrosine+blood 0 0 0.409230769 yes yes serum_aminoacids serum_aminoacids 1.81E-07 0.00913 dn up up up up no d18:1-20:1-SM+blood L-Tyrosine+blood 0 -0.517156863 0 yes serum_phospholipids serum_aminoacids 0.0992 0.00913 no no no up up no d18:1-24:1-SM+blood L-Tyrosine+blood 0 0 -0.421538462 yes serum_phospholipids serum_aminoacids 0.0123 0.00913 no dn dn up up no DL-methionine sulfoxide+blood L-Tyrosine+blood 0 0 0.548034188 yes serum_aminoacids serum_aminoacids 0.302 0.00913 no no no up up no Dorea L-Tyrosine+blood 0 0.531862745 0 yes Genus serum_aminoacids 0.00362 0.00913 up no dn up up no ErbB signaling pathway L-Tyrosine+blood 0.480701754 -0.505882353 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Ethanolamine+blood L-Tyrosine+blood 0 0 0.671111111 yes serum_aminoacids serum_aminoacids 0.122 0.00913 up no no up up no Fc epsilon RI signaling pathway L-Tyrosine+blood 0.466666667 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Focal adhesion L-Tyrosine+blood 0 0 -0.402307692 yes kegg serum_aminoacids NA 0.00913 no up up up up no Gap junction L-Tyrosine+blood 0 -0.561764706 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no GCA+stool L-Tyrosine+blood 0 0.7 0 yes stool_bileacids serum_aminoacids 0.0809 0.00913 no no no up up no GCDCA+blood L-Tyrosine+blood 0 0.526960784 0 yes serum_bileacids serum_aminoacids 0.31 0.00913 no no no up up no GCDCA+stool L-Tyrosine+blood -0.554945055 0.881818182 0 yes yes stool_bileacids serum_aminoacids 0.0471 0.00913 no dn no up up no GDCA+stool L-Tyrosine+blood 0 0.797268583 0 yes stool_bileacids serum_aminoacids 0.656 0.00913 no no no up up no Gemmiger L-Tyrosine+blood 0 0 0.550343273 butyrate-producing yes Genus serum_aminoacids 0.595 0.00913 no no no up up no Glioma L-Tyrosine+blood 0.529824561 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Glutathione metabolism L-Tyrosine+blood -0.473684211 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Glycolysis / Gluconeogenesis L-Tyrosine+blood -0.564912281 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no "Growth hormone synthesis, secretion and action" L-Tyrosine+blood 0 -0.552941176 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Hematopoietic cell lineage L-Tyrosine+blood 0 0 -0.545384615 yes kegg serum_aminoacids NA 0.00913 no no no up up no Hepatitis B L-Tyrosine+blood 0.5 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Hypertrophic cardiomyopathy L-Tyrosine+blood -0.48245614 0 0 yes kegg serum_aminoacids NA 0.00913 no up up up up no Inflammatory bowel disease L-Tyrosine+blood 0 0 -0.511538462 yes kegg serum_aminoacids NA 0.00913 no no no up up no Intestinal immune network for IgA production L-Tyrosine+blood 0 0 -0.592307692 yes kegg serum_aminoacids NA 0.00913 no no no up up no iso-heptanoic acid C7+blood L-Tyrosine+blood -0.636090226 0 0 yes serum_mcfa serum_aminoacids 0.00256 0.00913 up up no up up no isocapric acid iso-C6+blood L-Tyrosine+blood 0.547368421 0 0 yes serum_scfa serum_aminoacids 0.0458 0.00913 no no dn up up no L-2-Aminobutyric acid+blood L-Tyrosine+blood 0.491729323 0 0 yes yes serum_aminoacids serum_aminoacids 0.000328 0.00913 up up no up up no L-Arginine+blood L-Tyrosine+blood 0.57593985 0 0 yes serum_aminoacids serum_aminoacids 0.316 0.00913 no no no up up no L-Citrulline+blood L-Tyrosine+blood 0.445112782 0 0 yes serum_aminoacids serum_aminoacids 0.534 0.00913 no no no up up no L-Histidine+blood L-Tyrosine+blood 0.603007519 0 0.51042735 yes serum_aminoacids serum_aminoacids 0.109 0.00913 no no no up up no L-Isoleucine+blood L-Tyrosine+blood 0 0.644607843 0.673846154 yes yes serum_aminoacids serum_aminoacids 5.47E-06 0.00913 up up no up up no L-Leucine+blood L-Tyrosine+blood 0 0 0.626666667 yes yes serum_aminoacids serum_aminoacids 3.22E-05 0.00913 up up no up up no L-Lysine+blood L-Tyrosine+blood 0.511278195 0.531862745 0.541880342 yes yes serum_aminoacids serum_aminoacids 0.0107 0.00913 no up no up up no L-Methionine+blood L-Tyrosine+blood 0.882706767 0.585784314 0.513162393 yes serum_aminoacids serum_aminoacids 0.626 0.00913 no no no up up no L-Phenylalanine+blood L-Tyrosine+blood 0.846616541 0.754901961 0.76 yes yes serum_aminoacids serum_aminoacids 0.0103 0.00913 up up no up up no L-Phenylalanine+stool L-Tyrosine+blood 0 0 0.509774436 yes stool_cometabolism serum_aminoacids 0.398 0.00913 no no no up up no L-Proline+blood L-Tyrosine+blood 0 0.698529412 0 yes yes serum_aminoacids serum_aminoacids 0.00265 0.00913 up up no up up no L-Tryptophan+blood L-Tyrosine+blood 0.765413534 0.796568627 0.578119658 yes serum_aminoacids serum_aminoacids 0.164 0.00913 no no no up up no L-Tryptophan+stool L-Tyrosine+blood 0 0 0.502255639 yes stool_cometabolism serum_aminoacids 0.557 0.00913 no no no up up no L-Tyrosine+stool L-Tyrosine+blood 0 0 0.517293233 yes stool_cometabolism serum_aminoacids 0.44 0.00913 no no no up up no Leishmaniasis L-Tyrosine+blood -0.48245614 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Long-term potentiation L-Tyrosine+blood 0.471929825 0 0 yes kegg serum_aminoacids NA 0.00913 no no up up up no mRNA surveillance pathway L-Tyrosine+blood 0.589473684 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Non-alcoholic fatty liver disease L-Tyrosine+blood 0.521052632 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no p53 signaling pathway L-Tyrosine+blood 0.487719298 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Parabacteroides L-Tyrosine+blood 0 -0.534313725 0.512224319 yes Genus serum_aminoacids 4.19E-05 0.00913 no up up up up no Pathways in cancer L-Tyrosine+blood 0.728070175 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Phenylacetic acid+stool L-Tyrosine+blood 0 -0.790909091 0 yes stool_cometabolism serum_aminoacids 0.785 0.00913 no no no up up no Phosphatidylinositol signaling system L-Tyrosine+blood 0.561403509 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Phospholipase D signaling pathway L-Tyrosine+blood 0.478947368 0 0 yes kegg serum_aminoacids NA 0.00913 no up up up up no Platinum drug resistance L-Tyrosine+blood 0.485964912 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Prevotella L-Tyrosine+blood 0 0 0.417163783 acetate-producing yes Genus serum_aminoacids 0.287 0.00913 no no no up up no Progesterone-mediated oocyte maturation L-Tyrosine+blood 0.461403509 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Propionic acid+stool L-Tyrosine+blood 0 -0.654545455 0 yes yes stool_scfa serum_aminoacids 0.0436 0.00913 dn no up up up no Proteasome L-Tyrosine+blood 0 0.602941176 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Renal cell carcinoma L-Tyrosine+blood 0.478947368 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Rheumatoid arthritis L-Tyrosine+blood 0 0 -0.473076923 yes kegg serum_aminoacids NA 0.00913 no no no up up no RNA degradation L-Tyrosine+blood 0.528070175 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Roseburia L-Tyrosine+blood 0 0.62660956 0 butyrate-producing yes Genus serum_aminoacids 0.495 0.00913 no no no up up no Ruminococcus L-Tyrosine+blood 0 0.499080413 0 yes Genus serum_aminoacids 0.0679 0.00913 no no dn up up no Ruminococcus L-Tyrosine+blood 0 0.578431373 0 acetate-producing yes Genus serum_aminoacids 0.335 0.00913 no no no up up no Salmonella infection L-Tyrosine+blood 0 0 -0.452307692 yes kegg serum_aminoacids NA 0.00913 no no no up up no Serotonergic synapse L-Tyrosine+blood 0 -0.611764706 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Signaling pathways regulating pluripotency of stem cells L-Tyrosine+blood 0.540350877 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Sphingolipid signaling pathway L-Tyrosine+blood 0.577192982 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Spinocerebellar ataxia L-Tyrosine+blood 0.507017544 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Thyroid hormone signaling pathway L-Tyrosine+blood 0 0 -0.432307692 yes kegg serum_aminoacids NA 0.00913 no no no up up no total_stool_scfa+stool L-Tyrosine+blood 0 -0.663636364 0 yes stool_scfa serum_aminoacids 0.0534 0.00913 dn no up up up no Toxoplasmosis L-Tyrosine+blood 0 0 -0.475384615 yes kegg serum_aminoacids NA 0.00913 no no no up up no UDCA+stool L-Tyrosine+blood 0 0.672727273 0 yes stool_bileacids serum_aminoacids 0.266 0.00913 no no no up up no VEGF signaling pathway L-Tyrosine+blood 0.561403509 0 0 yes kegg serum_aminoacids NA 0.00913 no no no up up no Viral myocarditis L-Tyrosine+blood 0 0 -0.42 yes kegg serum_aminoacids NA 0.00913 no no no up up no 5-Hydroxytryptamine+stool L-Tyrosine+stool 0 0 0.483201581 stool_cometabolism stool_cometabolism 0.00862 0.44 dn dn no no no no Allograft rejection L-Tyrosine+stool 0 0 -0.581027668 kegg stool_cometabolism NA 0.44 no no no no no no Antigen processing and presentation L-Tyrosine+stool 0 0 -0.51552795 kegg stool_cometabolism NA 0.44 no no no no no no Apelin signaling pathway L-Tyrosine+stool -0.519091847 0 0 kegg stool_cometabolism NA 0.44 no no no no no no Autoimmune thyroid disease L-Tyrosine+stool 0 0 -0.581027668 kegg stool_cometabolism NA 0.44 no no no no no no Butyricicoccus L-Tyrosine+stool 0 0 -0.507733291 butyrate-producing Genus stool_cometabolism 0.852 0.44 no no no no no no CA+stool L-Tyrosine+stool 0 0 -0.60770751 stool_bileacids stool_cometabolism 0.827 0.44 no no no no no no CDCA+stool L-Tyrosine+stool 0 0 -0.592885375 stool_bileacids stool_cometabolism 0.663 0.44 no no no no no no Cell adhesion molecules L-Tyrosine+stool 0 0 -0.583286279 kegg stool_cometabolism NA 0.44 no no no no no no Cellular senescence L-Tyrosine+stool 0 0 -0.600225861 kegg stool_cometabolism NA 0.44 no no no no no no DCA+stool L-Tyrosine+stool -0.649122807 0 0 stool_bileacids stool_cometabolism 0.195 0.44 no no no no no no Endocytosis L-Tyrosine+stool 0 0 -0.565217391 kegg stool_cometabolism NA 0.44 no no no no no no Epstein-Barr virus infection L-Tyrosine+stool 0 0 -0.541501976 kegg stool_cometabolism NA 0.44 no no no no no no Gemmiger L-Tyrosine+stool -0.702116769 0 0 butyrate-producing Genus stool_cometabolism 0.595 0.44 no no no no no no Graft-versus-host disease L-Tyrosine+stool 0 0 -0.578769057 kegg stool_cometabolism NA 0.44 no no no no no no Herpes simplex virus 1 infection L-Tyrosine+stool 0 0 -0.496329757 kegg stool_cometabolism NA 0.44 no no no no no no Human cytomegalovirus infection L-Tyrosine+stool 0 0 -0.535855449 kegg stool_cometabolism NA 0.44 no no dn no no no Human immunodeficiency virus 1 infection L-Tyrosine+stool 0 0 -0.524562394 kegg stool_cometabolism NA 0.44 no no no no no no Human papillomavirus infection L-Tyrosine+stool 0 0 -0.514398645 kegg stool_cometabolism NA 0.44 no no no no no no Human T-cell leukemia virus 1 infection L-Tyrosine+stool 0 0 -0.521174478 kegg stool_cometabolism NA 0.44 no no no no no no Indole-3-Acetic acid+stool L-Tyrosine+stool 0 0 0.645256917 stool_cometabolism stool_cometabolism 0.304 0.44 no no no no no no Influenza A L-Tyrosine+stool 0.510835913 0 0 kegg stool_cometabolism NA 0.44 no no no no no no Isobutyric acid+stool L-Tyrosine+stool 0 0 0.481225296 stool_scfa stool_cometabolism 0.408 0.44 no no no no no no Isovaleric acid+stool L-Tyrosine+stool 0 0 0.449604743 stool_scfa stool_cometabolism 0.343 0.44 no no no no no no Kynurenic acid+stool L-Tyrosine+stool 0 0.65034965 0.435770751 stool_cometabolism stool_cometabolism 0.037 0.44 dn dn no no no no L-Phenylalanine+stool L-Tyrosine+stool 0.919504644 0.741258741 0.975296443 stool_cometabolism stool_cometabolism 0.398 0.44 no no no no no no L-Tryptophan+stool L-Tyrosine+stool 0.832817337 0.622377622 0.871541502 stool_cometabolism stool_cometabolism 0.557 0.44 no no no no no no Methanobrevibacter L-Tyrosine+stool 0 0 0.444554224 Genus stool_cometabolism 0.629 0.44 no no no no no no mTOR signaling pathway L-Tyrosine+stool -0.494324045 0 0 kegg stool_cometabolism NA 0.44 no no no no no no Natural killer cell mediated cytotoxicity L-Tyrosine+stool 0 0 -0.51552795 kegg stool_cometabolism NA 0.44 no no no no no no Neutrophil extracellular trap formation L-Tyrosine+stool 0.477812178 0 0 kegg stool_cometabolism NA 0.44 no no no no no no Pathogenic Escherichia coli infection L-Tyrosine+stool 0.471620227 0 0 kegg stool_cometabolism NA 0.44 no no no no no no Phagosome L-Tyrosine+stool 0 0 -0.462450593 kegg stool_cometabolism NA 0.44 no no no no no no RNA transport L-Tyrosine+stool -0.471620227 0 0 kegg stool_cometabolism NA 0.44 no no no no no no Succinivibrio L-Tyrosine+stool 0 0 -0.456470037 Genus stool_cometabolism 0.138 0.44 no no no no no no Tuberculosis L-Tyrosine+stool 0.502579979 0 0 kegg stool_cometabolism NA 0.44 no no dn no no no Type I diabetes mellitus L-Tyrosine+stool 0 0 -0.586674195 kegg stool_cometabolism NA 0.44 no no no no no no Viral carcinogenesis L-Tyrosine+stool 0 0 -0.555053642 kegg stool_cometabolism NA 0.44 no no no no no no Viral myocarditis L-Tyrosine+stool 0 0 -0.57312253 kegg stool_cometabolism NA 0.44 no no no no no no ¦Ø-MCA+stool L-Tyrosine+stool 0 -0.725213717 0 stool_bileacids stool_cometabolism 0.919 0.44 no no no no no no 16:0/16:0-PC+blood L-Tyrosine+urine 0.742647059 0 0 serum_phospholipids urine_cometabolism 0.00079 0.45 no up up no no no 16:0/18:0-PS+blood L-Tyrosine+urine -0.492647059 0 0 serum_phospholipids urine_cometabolism 0.377 0.45 no no no no no no 16:0/18:1-PC+blood L-Tyrosine+urine 0.642156863 0 0 serum_phospholipids urine_cometabolism 6.15E-07 0.45 up up up no no no 16:0/18:2-PC+blood L-Tyrosine+urine 0.696078431 0 0 serum_phospholipids urine_cometabolism 3.24E-06 0.45 no up up no no no 16:0/20:3-PC+blood L-Tyrosine+urine 0.68872549 0 0 serum_phospholipids urine_cometabolism 5.43E-06 0.45 no up up no no no 16:0/20:4-PC+blood L-Tyrosine+urine 0.56372549 0 0 serum_phospholipids urine_cometabolism 0.0262 0.45 no up no no no no 16:0/22:6-PE+blood L-Tyrosine+urine -0.583333333 0 0 serum_phospholipids urine_cometabolism 0.000934 0.45 up up no no no no 16:1/16:0-PC+blood L-Tyrosine+urine 0.610294118 0 0 serum_phospholipids urine_cometabolism 0.0215 0.45 no up up no no no 16:1/16:1-PC+blood L-Tyrosine+urine 0.5 0 0 serum_phospholipids urine_cometabolism 0.0177 0.45 no no up no no no 16:1/18:2-PG+blood L-Tyrosine+urine 0.492647059 0 0 serum_phospholipids urine_cometabolism 1.40E-08 0.45 no up up no no no 18:0-LPE+blood L-Tyrosine+urine -0.666666667 0 0 serum_phospholipids urine_cometabolism 0.491 0.45 no no no no no no 18:0/16:0-PC+blood L-Tyrosine+urine 0.639705882 0 0 serum_phospholipids urine_cometabolism 9.64E-07 0.45 up up up no no no 18:0/18:1-PE+blood L-Tyrosine+urine -0.742647059 0 0 serum_phospholipids urine_cometabolism 0.00716 0.45 up up no no no no 18:0/18:2-PC+blood L-Tyrosine+urine 0.605392157 0 0 serum_phospholipids urine_cometabolism 1.74E-06 0.45 no up up no no no 18:0/18:2-PI+blood L-Tyrosine+urine 0 0 0.480519481 serum_phospholipids urine_cometabolism 0.179 0.45 no no no no no no 18:0/20:4-PC+blood L-Tyrosine+urine 0.583333333 0 0 serum_phospholipids urine_cometabolism 0.454 0.45 no no no no no no 18:0/22:6-PE+blood L-Tyrosine+urine -0.556372549 0 0 serum_phospholipids urine_cometabolism 0.00022 0.45 up up no no no no 18:1/16:0-PC+blood L-Tyrosine+urine 0.708333333 0 0 serum_phospholipids urine_cometabolism 2.43E-05 0.45 no up up no no no 18:1/18:0-PC+blood L-Tyrosine+urine 0.669117647 0 0 serum_phospholipids urine_cometabolism 1.83E-06 0.45 no up up no no no 18:1/18:1-PC+blood L-Tyrosine+urine 0.718137255 0 0 serum_phospholipids urine_cometabolism 1.34E-05 0.45 no up up no no no 18:1/18:1-PE+blood L-Tyrosine+urine -0.708333333 0 0 serum_phospholipids urine_cometabolism 1.03E-05 0.45 up up no no no no 18:1/20:4-PC+blood L-Tyrosine+urine 0.531862745 0 0 serum_phospholipids urine_cometabolism 0.582 0.45 no no no no no no 18:2/16:0-PC+blood L-Tyrosine+urine 0.642156863 0 0 serum_phospholipids urine_cometabolism 8.67E-05 0.45 no up up no no no 2-hydroxyhippuric acid+urine L-Tyrosine+urine -0.514285714 -0.571929825 -0.588376068 urine_cometabolism urine_cometabolism 0.215 0.45 no no no no no no 2-hydroxyphenylacetic acid+urine L-Tyrosine+urine 0 0 -0.442735043 urine_cometabolism urine_cometabolism 0.763 0.45 no no no no no no 20:1-LPA+blood L-Tyrosine+urine 0 -0.593406593 0 serum_phospholipids urine_cometabolism 0.0187 0.45 dn dn no no no no 20:3/16:0-PC+blood L-Tyrosine+urine 0.610294118 0 0 serum_phospholipids urine_cometabolism 0.00405 0.45 no up up no no no 20:4-LPA+blood L-Tyrosine+urine 0 -0.554945055 0 serum_phospholipids urine_cometabolism 0.398 0.45 no no no no no no 24:1+blood L-Tyrosine+urine 0.595588235 0 0 serum_fattyacid urine_cometabolism 0.00582 0.45 no dn dn no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" L-Tyrosine+urine 0 0 0.516581197 urine_cometabolism urine_cometabolism 0.0125 0.45 up up no no no no 3-Hydroxy-L-kynurenine+urine L-Tyrosine+urine 0.628571429 0.733333333 0.61025641 urine_cometabolism urine_cometabolism 0.401 0.45 no no no no no no 3-Hydroxytyramine hydrochloride+urine L-Tyrosine+urine 0 0 0.585641026 urine_cometabolism urine_cometabolism 0.288 0.45 no no no no no no 5-Hydroxytryptamine+urine L-Tyrosine+urine 0 0.547368421 0 urine_cometabolism urine_cometabolism 0.171 0.45 no no no no no no Apelin signaling pathway L-Tyrosine+urine 0 0 0.541538462 kegg urine_cometabolism NA 0.45 no no no no no no Apoptosis L-Tyrosine+urine 0 0 -0.404615385 kegg urine_cometabolism NA 0.45 no no no no no no Butyric acid+stool L-Tyrosine+urine 0.683516484 0 0 yes stool_scfa urine_cometabolism 0.102 0.45 dn no no no no no Butyricicoccus L-Tyrosine+urine 0 0.45606963 0 butyrate-producing Genus urine_cometabolism 0.852 0.45 no no no no no no CDCA+blood L-Tyrosine+urine 0 0.598901099 0 serum_bileacids urine_cometabolism 0.506 0.45 no no no no no no Clostridium L-Tyrosine+urine -0.50366382 0 0 Genus urine_cometabolism 0.925 0.45 no no no no no no Coronavirus disease - COVID-19 L-Tyrosine+urine 0 0 0.493846154 kegg urine_cometabolism NA 0.45 no no no no no no Cytosolic DNA-sensing pathway L-Tyrosine+urine 0.494736842 0 0 kegg urine_cometabolism NA 0.45 no no no no no no EGFR tyrosine kinase inhibitor resistance L-Tyrosine+urine 0 0 0.568461538 kegg urine_cometabolism NA 0.45 no no no no no no Fc epsilon RI signaling pathway L-Tyrosine+urine 0 0 -0.427692308 kegg urine_cometabolism NA 0.45 no no no no no no Fluid shear stress and atherosclerosis L-Tyrosine+urine 0 0 -0.463846154 kegg urine_cometabolism NA 0.45 no no no no no no Glucagon signaling pathway L-Tyrosine+urine 0 0 0.56 kegg urine_cometabolism NA 0.45 no no no no no no Glycine+blood L-Tyrosine+urine 0 -0.774725275 0 serum_aminoacids urine_cometabolism 0.00408 0.45 dn no up no no no HIF-1 signaling pathway L-Tyrosine+urine 0 0 0.475384615 kegg urine_cometabolism NA 0.45 no no no no no no Insulin signaling pathway L-Tyrosine+urine 0 0 0.528461538 kegg urine_cometabolism NA 0.45 no no no no no no iso-DCA+blood L-Tyrosine+urine 0.598039216 0 0 serum_bileacids urine_cometabolism 0.38 0.45 no no no no no no L-Histidine+blood L-Tyrosine+urine 0.512254902 0 0 serum_aminoacids urine_cometabolism 0.109 0.45 no no no no no no L-Phenylalanine+urine L-Tyrosine+urine 0.845112782 0.807017544 0.885128205 urine_cometabolism urine_cometabolism 0.0908 0.45 no up no no no no L-Tryptophan+urine L-Tyrosine+urine 0.834586466 0.759649123 0.883760684 urine_cometabolism urine_cometabolism 0.226 0.45 no no no no no no Lysosome L-Tyrosine+urine 0 0 -0.436923077 kegg urine_cometabolism NA 0.45 no no no no no no mRNA surveillance pathway L-Tyrosine+urine 0 0 0.462307692 kegg urine_cometabolism NA 0.45 no no no no no no mTOR signaling pathway L-Tyrosine+urine 0 0 0.509230769 kegg urine_cometabolism NA 0.45 no no no no no no MUFA%+blood L-Tyrosine+urine 0 -0.818681319 0 serum_fattyacid urine_cometabolism 0.00142 0.45 up no dn no no no Neuroactive ligand-receptor interaction L-Tyrosine+urine 0 0 -0.442307692 kegg urine_cometabolism NA 0.45 up up up no no no Neurotrophin signaling pathway L-Tyrosine+urine 0.524561404 0 0 kegg urine_cometabolism NA 0.45 no no no no no no "Parathyroid hormone synthesis, secretion and action" L-Tyrosine+urine 0 0 0.484615385 kegg urine_cometabolism NA 0.45 no no no no no no Pertussis L-Tyrosine+urine 0 0 -0.466923077 kegg urine_cometabolism NA 0.45 no no dn no no no Phagosome L-Tyrosine+urine 0 0 -0.415384615 kegg urine_cometabolism NA 0.45 no no no no no no PI3K-Akt signaling pathway L-Tyrosine+urine 0 0 0.566153846 yes kegg urine_cometabolism NA 0.45 no up up no no no Prevotella L-Tyrosine+urine -0.462539691 0 0 acetate-producing Genus urine_cometabolism 0.287 0.45 no no no no no no PUFA/MUFA+blood L-Tyrosine+urine 0.549019608 0 0 serum_fattyacid urine_cometabolism 0.00108 0.45 dn no up no no no PUFA%+blood L-Tyrosine+urine 0.740196078 -0.730769231 0 serum_fattyacid urine_cometabolism 0.0013 0.45 dn no up no no no Pyramidobacter L-Tyrosine+urine 0 0 0.47249008 Genus urine_cometabolism 0.45 0.45 no no no no no no Relaxin signaling pathway L-Tyrosine+urine 0.514035088 0 0 kegg urine_cometabolism NA 0.45 no no no no no no Rheumatoid arthritis L-Tyrosine+urine 0 0 -0.456153846 kegg urine_cometabolism NA 0.45 no no no no no no Ribosome L-Tyrosine+urine 0 0 0.493846154 kegg urine_cometabolism NA 0.45 no no no no no no RNA transport L-Tyrosine+urine 0 0 0.532307692 kegg urine_cometabolism NA 0.45 no no no no no no Serine+blood L-Tyrosine+urine 0.504901961 0 0 serum_aminoacids urine_cometabolism 0.942 0.45 no no no no no no SFA%+blood L-Tyrosine+urine 0.745098039 -0.791208791 0 serum_fattyacid urine_cometabolism 0.0236 0.45 no up no no no no Spliceosome L-Tyrosine+urine 0 0 0.420769231 kegg urine_cometabolism NA 0.45 no no no no no no T cell receptor signaling pathway L-Tyrosine+urine 0 0 0.415384615 kegg urine_cometabolism NA 0.45 no no no no no no TNF signaling pathway L-Tyrosine+urine 0.542105263 0 0 kegg urine_cometabolism NA 0.45 no no no no no no Transcriptional misregulation in cancer L-Tyrosine+urine 0 0 0.436923077 kegg urine_cometabolism NA 0.45 no no no no no no Tuberculosis L-Tyrosine+urine 0 0 -0.459230769 kegg urine_cometabolism NA 0.45 no no dn no no no TUDCA+blood L-Tyrosine+urine -0.654078197 0 0 yes serum_bileacids urine_cometabolism 0.0282 0.45 no no dn no no no TXB2+blood L-Tyrosine+urine 0 -0.657468598 0 yes serum_ARA urine_cometabolism 0.0644 0.45 dn no no no no no UFA%+blood L-Tyrosine+urine 0.649509804 -0.851648352 0 serum_fattyacid urine_cometabolism 0.0236 0.45 no dn no no no no Actinomyces Lachnobacterium 0 0.436443089 0 Genus Genus 0.621 0.867 no no no no no no Coprococcus Lachnospira 0.540309531 0 0 butyrate-producing butyrate-producing Genus Genus 0.612 0.279 no no no no no no 12-HEPE+blood lauric acid C12+blood 0.515231277 0 0 serum_ARA serum_mcfa 0.312 0.015 no no no no dn dn 14:0/20:4-PC+blood lauric acid C12+blood -0.458646617 0 0 serum_phospholipids serum_mcfa 0.486 0.015 no no no no dn dn 16:0/14:0-PC+blood lauric acid C12+blood 0.488721805 0 0 serum_phospholipids serum_mcfa 0.0206 0.015 no up up no dn dn 16:0/16:0-PC+blood lauric acid C12+blood 0 0 -0.422222222 serum_phospholipids serum_mcfa 0.00079 0.015 no up up no dn dn 16:0/16:0-PI+blood lauric acid C12+blood -0.545864662 0 0 serum_phospholipids serum_mcfa 0.358 0.015 no no no no dn dn 16:0/16:1-PC+blood lauric acid C12+blood 0 0 -0.411965812 serum_phospholipids serum_mcfa 0.00283 0.015 up up no no dn dn 16:0/16:1-PI+blood lauric acid C12+blood -0.657142857 0 -0.461880342 serum_phospholipids serum_mcfa 0.262 0.015 no no no no dn dn 16:0/18:0-PS+blood lauric acid C12+blood -0.577443609 0 0 serum_phospholipids serum_mcfa 0.377 0.015 no no no no dn dn 16:0/18:1-PC+blood lauric acid C12+blood 0.488721805 0 0 serum_phospholipids serum_mcfa 6.15E-07 0.015 up up up no dn dn 16:0/18:1-PE+blood lauric acid C12+blood -0.583458647 0 0 serum_phospholipids serum_mcfa 0.000107 0.015 up up no no dn dn 16:0/18:2-PC+blood lauric acid C12+blood 0.527819549 0 0 serum_phospholipids serum_mcfa 3.24E-06 0.015 no up up no dn dn 16:0/18:2-PI+blood lauric acid C12+blood -0.473684211 0 0 serum_phospholipids serum_mcfa 0.269 0.015 no no no no dn dn 16:0/18:3-PC+blood lauric acid C12+blood -0.508270677 0 -0.492649573 serum_phospholipids serum_mcfa 0.00216 0.015 no up up no dn dn 16:0/20:3-PC+blood lauric acid C12+blood 0.535338346 0.544117647 0 serum_phospholipids serum_mcfa 5.43E-06 0.015 no up up no dn dn 16:0/20:4-PC+blood lauric acid C12+blood 0.621052632 0 0 serum_phospholipids serum_mcfa 0.0262 0.015 no up no no dn dn 18:0/16:0-PC+blood lauric acid C12+blood 0.481203008 0 0 serum_phospholipids serum_mcfa 9.64E-07 0.015 up up up no dn dn 18:0/18:0-PC+blood lauric acid C12+blood 0 0 -0.456410256 serum_phospholipids serum_mcfa 0.426 0.015 no no no no dn dn 18:0/18:0-PE+blood lauric acid C12+blood -0.44962406 0 0 serum_phospholipids serum_mcfa 0.00896 0.015 up up no no dn dn 18:0/18:0-PS+blood lauric acid C12+blood -0.479699248 0 0 serum_phospholipids serum_mcfa 0.00617 0.015 no up no no dn dn 18:0/18:1-PC+blood lauric acid C12+blood 0 0 -0.45982906 serum_phospholipids serum_mcfa 0.393 0.015 no no no no dn dn 18:0/18:1-PE+blood lauric acid C12+blood -0.514285714 0 0 serum_phospholipids serum_mcfa 0.00716 0.015 up up no no dn dn 18:0/18:2-PC+blood lauric acid C12+blood 0.532330827 0 0 serum_phospholipids serum_mcfa 1.74E-06 0.015 no up up no dn dn 18:0/20:3-PC+blood lauric acid C12+blood 0 0 -0.448888889 serum_phospholipids serum_mcfa 0.0682 0.015 no up no no dn dn 18:0/20:4-PC+blood lauric acid C12+blood 0.606015038 0 0 serum_phospholipids serum_mcfa 0.454 0.015 no no no no dn dn 18:0/22:6-PC+blood lauric acid C12+blood 0 -0.487745098 0 serum_phospholipids serum_mcfa 0.0775 0.015 no no up no dn dn 18:0/22:6-PE+blood lauric acid C12+blood -0.458646617 -0.524509804 0 serum_phospholipids serum_mcfa 0.00022 0.015 up up no no dn dn 18:0+blood lauric acid C12+blood 0 0 -0.556923077 serum_fattyacid serum_mcfa 0.344 0.015 no no no no dn dn 18:1-LPC+blood lauric acid C12+blood 0.609022556 0 0 serum_phospholipids serum_mcfa 0.179 0.015 no no no no dn dn 18:1/16:0-PC+blood lauric acid C12+blood 0.554887218 0 0 serum_phospholipids serum_mcfa 2.43E-05 0.015 no up up no dn dn 18:1/16:0-PE+blood lauric acid C12+blood -0.587969925 0 0 serum_phospholipids serum_mcfa 0.000182 0.015 up up no no dn dn 18:1/16:1-PE+blood lauric acid C12+blood -0.645112782 0 0 serum_phospholipids serum_mcfa 0.000184 0.015 up up no no dn dn 18:1/18:0-PC+blood lauric acid C12+blood 0.514285714 0 0 serum_phospholipids serum_mcfa 1.83E-06 0.015 no up up no dn dn 18:1/18:0-PE+blood lauric acid C12+blood -0.553383459 0 0 serum_phospholipids serum_mcfa 1.39E-06 0.015 up up no no dn dn 18:1/18:1-PC+blood lauric acid C12+blood 0.490225564 0.531862745 0 serum_phospholipids serum_mcfa 1.34E-05 0.015 no up up no dn dn 18:1/18:1-PE+blood lauric acid C12+blood -0.586466165 0 0 serum_phospholipids serum_mcfa 1.03E-05 0.015 up up no no dn dn 18:1/18:1-PI+blood lauric acid C12+blood 0.539849624 0 0 serum_phospholipids serum_mcfa 0.111 0.015 dn no no no dn dn 18:1/20:3-PC+blood lauric acid C12+blood 0 0.551470588 0 serum_phospholipids serum_mcfa 0.00872 0.015 no up up no dn dn 18:1/20:4-PI+blood lauric acid C12+blood 0 0 -0.501538462 serum_phospholipids serum_mcfa 0.192 0.015 no no no no dn dn 18:2-LPC+blood lauric acid C12+blood 0.618045113 0 0 serum_phospholipids serum_mcfa 0.00743 0.015 dn no up no dn dn 18:2-LPE+blood lauric acid C12+blood 0 0.595588235 0 serum_phospholipids serum_mcfa 0.112 0.015 no no no no dn dn 18:2/16:0-PC+blood lauric acid C12+blood 0.536842105 0 0 serum_phospholipids serum_mcfa 8.67E-05 0.015 no up up no dn dn 18:2/18:1-PC+blood lauric acid C12+blood 0.461654135 0 0 serum_phospholipids serum_mcfa 2.30E-05 0.015 dn up up no dn dn 18:2/18:2-PS+blood lauric acid C12+blood -0.530827068 0 0 serum_phospholipids serum_mcfa 0.00674 0.015 up up no no dn dn 18:3/16:0-PE+blood lauric acid C12+blood -0.839097744 0 0 serum_phospholipids serum_mcfa 0.00149 0.015 up up no no dn dn 18:3n6+blood lauric acid C12+blood -0.461654135 0 -0.507692308 serum_fattyacid serum_mcfa 0.0463 0.015 up no dn no dn dn 2-methyl-butyric acid m-C4+blood lauric acid C12+blood 0.496240602 0 0 serum_scfa serum_mcfa 0.262 0.015 no no no no dn dn 20:2/18:0-PC+blood lauric acid C12+blood 0 0 -0.450940171 serum_phospholipids serum_mcfa 0.0427 0.015 no up no no dn dn 20:2/18:1-PE+blood lauric acid C12+blood -0.634586466 0 0 serum_phospholipids serum_mcfa 0.00208 0.015 up up no no dn dn 20:2+blood lauric acid C12+blood 0 0.598039216 0 serum_fattyacid serum_mcfa 0.478 0.015 no no no no dn dn 20:3-LPE+blood lauric acid C12+blood 0 0.571078431 0 serum_phospholipids serum_mcfa 0.084 0.015 no up no no dn dn 20:3/16:0-PC+blood lauric acid C12+blood 0.637593985 0 0 serum_phospholipids serum_mcfa 0.00405 0.015 no up up no dn dn 20:4/16:0-PE+blood lauric acid C12+blood -0.482706767 0 0 serum_phospholipids serum_mcfa 0.00529 0.015 no up up no dn dn 20:5-LPC+blood lauric acid C12+blood 0 -0.629901961 0 serum_phospholipids serum_mcfa 0.558 0.015 no no no no dn dn 22:1-LPA+blood lauric acid C12+blood 0 0.49754902 0 serum_phospholipids serum_mcfa 0.00373 0.015 no up up no dn dn 22:2-LPA+blood lauric acid C12+blood 0 0.595588235 0 serum_phospholipids serum_mcfa 0.0443 0.015 dn no no no dn dn 22:6-LPC+blood lauric acid C12+blood 0 -0.556372549 0 serum_phospholipids serum_mcfa 0.127 0.015 no no up no dn dn capric acid C6+blood lauric acid C12+blood 0 0 0.404444444 serum_scfa serum_mcfa 0.433 0.015 no no no no dn dn Creatinine+blood lauric acid C12+blood 0.673684211 0 0 serum_choline serum_mcfa 0.437 0.015 no no no no dn dn Cysteine+blood lauric acid C12+blood 0.544360902 0.585784314 0 yes serum_aminoacids serum_mcfa 1.81E-07 0.015 dn up up no dn dn d18:1-14:0-SM+blood lauric acid C12+blood -0.50075188 0 0 serum_phospholipids serum_mcfa 0.94 0.015 no no no no dn dn d18:1-14:1-SM+blood lauric acid C12+blood -0.553383459 0 0 serum_phospholipids serum_mcfa 0.0952 0.015 no dn no no dn dn decanoic acid C10+blood lauric acid C12+blood 0.855639098 0.620098039 0.556923077 serum_mcfa serum_mcfa 6.64E-11 0.015 dn dn no no dn dn HDCA+blood lauric acid C12+blood 0.457488141 0 0.565895059 serum_bileacids serum_mcfa 0.483 0.015 no no no no dn dn heptanoic acid C7+blood lauric acid C12+blood 0.464661654 0.806372549 0 serum_mcfa serum_mcfa 8.27E-11 0.015 dn dn no no dn dn L-Alanine+blood lauric acid C12+blood 0 0 -0.540512821 yes serum_aminoacids serum_mcfa 0.00138 0.015 up up no no dn dn L-Arginine+blood lauric acid C12+blood 0.496240602 0 0 serum_aminoacids serum_mcfa 0.316 0.015 no no no no dn dn L-Lysine+blood lauric acid C12+blood 0.54887218 0.492647059 0 yes serum_aminoacids serum_mcfa 0.0107 0.015 no up no no dn dn L-Methionine+blood lauric acid C12+blood 0.604511278 0 0 serum_aminoacids serum_mcfa 0.626 0.015 no no no no dn dn L-Phenylalanine+blood lauric acid C12+blood 0.47518797 0 0 yes serum_aminoacids serum_mcfa 0.0103 0.015 up up no no dn dn L-Tryptophan+blood lauric acid C12+blood 0.612030075 0 0 serum_aminoacids serum_mcfa 0.164 0.015 no no no no dn dn 12-ketoDCA+blood LCA+blood 0.472304606 0.832322049 0.693890105 serum_bileacids serum_bileacids 0.517 0.884 no no no no no no "12,13-EPOME+blood" LCA+blood 0 0 0.462194374 serum_ARA serum_bileacids 0.901 0.884 no no no no no no 14:0/18:2-PC+blood LCA+blood -0.450686011 0 0 serum_phospholipids serum_bileacids 0.102 0.884 no up no no no no 16:0/16:0-PI+blood LCA+blood -0.452292735 0 0 serum_phospholipids serum_bileacids 0.358 0.884 no no no no no no 16:0/18:2-PI+blood LCA+blood -0.517365047 0 0 serum_phospholipids serum_bileacids 0.269 0.884 no no no no no no 18:0-LPC+blood LCA+blood 0 0.516219364 0 serum_phospholipids serum_bileacids 0.554 0.884 no no no no no no 18:0/20:3-PC+blood LCA+blood -0.582437358 0 0 serum_phospholipids serum_bileacids 0.0682 0.884 no up no no no no 18:0/22:6-PC+blood LCA+blood -0.529415475 0 0 serum_phospholipids serum_bileacids 0.0775 0.884 no no up no no no 18:0/22:6-PI+blood LCA+blood -0.695711382 0 0 serum_phospholipids serum_bileacids 0.425 0.884 no no no no no no 18:1-LPE+blood LCA+blood 0 0 -0.47474693 serum_phospholipids serum_bileacids 0.117 0.884 no no no no no no 18:1/16:0-PE+blood LCA+blood 0 -0.504747823 0 serum_phospholipids serum_bileacids 0.000182 0.884 up up no no no no 18:3n3+blood LCA+blood -0.487640657 0 0 serum_fattyacid serum_bileacids 0.291 0.884 no no no no no no 20:0-LPC+blood LCA+blood 0 0.510483593 0 serum_phospholipids serum_bileacids 0.199 0.884 no no no no no no 20:1-LPE+blood LCA+blood 0 0 -0.444152928 serum_phospholipids serum_bileacids 0.465 0.884 no no no no no no 20:1/20:4-PC+blood LCA+blood -0.499691085 0 0 serum_phospholipids serum_bileacids 0.0419 0.884 no no up no no no 20:2/18:0-PC+blood LCA+blood -0.550302883 0 0 serum_phospholipids serum_bileacids 0.0427 0.884 no up no no no no 20:2/18:1-PE+blood LCA+blood -0.465146525 0 0 serum_phospholipids serum_bileacids 0.00208 0.884 up up no no no no 20:3-LPE+blood LCA+blood 0 0 -0.508220368 serum_phospholipids serum_bileacids 0.084 0.884 no up no no no no 20:3/16:0-PC+blood LCA+blood 0.526202027 0 0 serum_phospholipids serum_bileacids 0.00405 0.884 no up up no no no 20:3n6+blood LCA+blood -0.474786867 0 0 serum_fattyacid serum_bileacids 0.0884 0.884 up no no no no no 20:5/18:0-PC+blood LCA+blood -0.447472564 0 0 serum_phospholipids serum_bileacids 3.97E-06 0.884 no up up no no no 22:6-LPC+blood LCA+blood -0.560746588 0 0 serum_phospholipids serum_bileacids 0.127 0.884 no no up no no no 22:6n3+blood LCA+blood -0.613768471 0 0 serum_fattyacid serum_bileacids 0.792 0.884 no no no no no no 24:1+blood LCA+blood 0 -0.636670549 0 serum_fattyacid serum_bileacids 0.00582 0.884 no dn dn no no no 3-(3-Hydroxyphenyl)propanoic acid+stool LCA+blood -0.717800578 0 -0.460356566 stool_cometabolism serum_bileacids 0.33 0.884 no no no no no no 4-hydroxybenzoic acid+stool LCA+blood 0 0 -0.463509693 stool_cometabolism serum_bileacids 0.0536 0.884 no dn no no no no ACA+blood LCA+blood 0.642060086 0 0 serum_bileacids serum_bileacids 0.338 0.884 no no no no no no acetic acid C2+blood LCA+blood -0.476393591 0 0 serum_scfa serum_bileacids 0.000193 0.884 up dn no no no no Adipocytokine signaling pathway LCA+blood 0.500773396 0 0 kegg serum_bileacids NA 0.884 no no no no no no AGE-RAGE signaling pathway in diabetic complications LCA+blood -0.51375641 0 0 kegg serum_bileacids NA 0.884 no no no no no no Akkermansia LCA+blood -0.473819742 0 0 acetate-producing Genus serum_bileacids 0.23 0.884 no no no no no no Alistipes LCA+blood 0.551980231 0 0 Genus serum_bileacids 0.0114 0.884 no up no no no no AMPK signaling pathway LCA+blood 0.489645098 0 0 kegg serum_bileacids NA 0.884 no no no no no no Blautia LCA+blood -0.497281 0 -0.41245193 acetate-producing Genus serum_bileacids 1.36E-05 0.884 up dn dn no no no CA+blood LCA+blood 0.586674764 0 0 serum_bileacids serum_bileacids 0.606 0.884 no no no no no no CA+stool LCA+blood -0.570849278 0 0 stool_bileacids serum_bileacids 0.827 0.884 no no no no no no CDCA+stool LCA+blood -0.553893359 0 -0.472969074 stool_bileacids serum_bileacids 0.663 0.884 no no no no no no Clostridium LCA+blood -0.544884232 -0.484381641 0 Genus serum_bileacids 0.925 0.884 no no no no no no Clostridium LCA+blood -0.494593535 -0.484381641 0 Genus serum_bileacids 0.925 0.884 no no no no no no Coronavirus disease - COVID-19 LCA+blood 0.471097935 0 0 kegg serum_bileacids NA 0.884 no no no no no no Cytokine-cytokine receptor interaction LCA+blood -0.472952651 0 0 kegg serum_bileacids NA 0.884 no no no no no no d18:0-24:1-SM+blood LCA+blood 0 0.559237644 0 serum_phospholipids serum_bileacids 0.0609 0.884 no dn dn no no no d18:1-24:1-SM+blood LCA+blood 0 0.504747823 0 serum_phospholipids serum_bileacids 0.0123 0.884 no dn dn no no no DPA+blood LCA+blood -0.45871963 0 0 serum_ARA serum_bileacids 0.519 0.884 no no no no no no Endocrine resistance LCA+blood 0 0.50356808 0 kegg serum_bileacids NA 0.884 no no no no no no Ethanolamine+blood LCA+blood 0.449882649 0 0 serum_aminoacids serum_bileacids 0.122 0.884 up no no no no no Faecalibacterium LCA+blood 0 0 -0.501287442 butyrate-producing Genus serum_bileacids 0.0039 0.884 no dn dn no no no Fc gamma R-mediated phagocytosis LCA+blood -0.485935665 0 0 kegg serum_bileacids NA 0.884 no no no no no no FoxO signaling pathway LCA+blood -0.582380912 0 0 kegg serum_bileacids NA 0.884 no no no no no no Gemmiger LCA+blood 0.504511257 0 0 butyrate-producing Genus serum_bileacids 0.595 0.884 no no no no no no GLCA+blood LCA+blood 0.551140312 0.568342145 0.546695481 serum_bileacids serum_bileacids 0.319 0.884 no no no no no no Glycine+blood LCA+blood 0.520578494 0 0 serum_aminoacids serum_bileacids 0.00408 0.884 dn no up no no no GUDCA+blood LCA+blood 0 0 -0.519018251 serum_bileacids serum_bileacids 0.0766 0.884 no no dn no no no HCA+stool LCA+blood -0.661280847 0 -0.717336429 stool_bileacids serum_bileacids 0.155 0.884 no no no no no no HDCA+blood LCA+blood 0 0.709282373 0 serum_bileacids serum_bileacids 0.483 0.884 no no no no no no HDCA+stool LCA+blood 0.661280847 0 0.472969074 stool_bileacids serum_bileacids 0.176 0.884 no no no no no no heptanoic acid C7+blood LCA+blood 0 0.556369759 0 serum_mcfa serum_bileacids 8.27E-11 0.884 dn dn no no no no Hypotaurine+blood LCA+blood 0.58725753 0 0 serum_aminoacids serum_bileacids 0.933 0.884 no no no no no no iso-LCA+blood LCA+blood 0.838197425 0.687919463 0.707054682 serum_bileacids serum_bileacids 0.507 0.884 no no no no no no iso-LCA+stool LCA+blood 0.645211818 0 0.663733268 stool_bileacids serum_bileacids 0.72 0.884 no no no no no no L-Glutamine+blood LCA+blood 0.486837295 0 0 serum_aminoacids serum_bileacids 0.639 0.884 no no no no no no L-Proline+blood LCA+blood 0.56154995 0 0 yes serum_aminoacids serum_bileacids 0.00265 0.884 up up no no no no L-Threonine+blood LCA+blood 0 0 -0.406000407 serum_aminoacids serum_bileacids 0.0538 0.884 dn no up no no no LCA+stool LCA+blood 0 0 0.458780002 stool_bileacids serum_bileacids 0.314 0.884 no no no no no no Lipid and atherosclerosis LCA+blood -0.491499814 0 0 kegg serum_bileacids NA 0.884 no no no no no no Longevity regulating pathway - multiple species LCA+blood -0.493354531 0 0 kegg serum_bileacids NA 0.884 no no no no no no Mitophagy - animal LCA+blood 0.52859414 0 0 kegg serum_bileacids NA 0.884 no no no no no no nutriCA+stool LCA+blood -0.672584793 0 -0.618012924 stool_bileacids serum_bileacids 0.481 0.884 no no no no no no Olfactory transduction LCA+blood -0.498918679 0 0 kegg serum_bileacids NA 0.884 no no no no no no Parkinson disease LCA+blood 0.485935665 0 0 kegg serum_bileacids NA 0.884 no no no no no no Pathways of neurodegeneration - multiple diseases LCA+blood 0.497063963 0 0 kegg serum_bileacids NA 0.884 no no no no no no Peroxisome LCA+blood -0.539722438 0 0 kegg serum_bileacids NA 0.884 no no no no no no Pertussis LCA+blood -0.471097935 0 0 kegg serum_bileacids NA 0.884 no no dn no no no Prevotella LCA+blood 0.556660799 0 0 Genus serum_bileacids 0.367 0.884 no no no no no no Prolactin signaling pathway LCA+blood 0 0 0.424510822 kegg serum_bileacids NA 0.884 no no no no no no Proteoglycans in cancer LCA+blood 0.510046977 0 0 kegg serum_bileacids NA 0.884 no no no no no no Regulation of actin cytoskeleton LCA+blood 0 -0.505257906 0 kegg serum_bileacids NA 0.884 no no no no no no Ribosome LCA+blood 0.471097935 0 0 kegg serum_bileacids NA 0.884 no no no no no no Shigellosis LCA+blood 0.576816763 0 0 kegg serum_bileacids NA 0.884 no no no no no no Ubiquitin mediated proteolysis LCA+blood 0.530448856 0 0 kegg serum_bileacids NA 0.884 no no no no no no UDCA+stool LCA+blood 0 0 -0.704723921 stool_bileacids serum_bileacids 0.266 0.884 no no no no no no 12-ketoDCA+stool LCA+stool 0.589267286 0.71803963 0.633399209 stool_bileacids stool_bileacids 0.505 0.314 no no no no no no 4-hydroxybenzoic acid+stool LCA+stool 0 -0.678321678 0 stool_cometabolism stool_bileacids 0.0536 0.314 no dn no no no no AGE-RAGE signaling pathway in diabetic complications LCA+stool 0 0 0.569734613 kegg stool_bileacids NA 0.314 no no no no no no Akkermansia LCA+stool 0 0 0.424794763 acetate-producing Genus stool_bileacids 0.23 0.314 no no no no no no Aldosterone synthesis and secretion LCA+stool 0 0.709090909 0 kegg stool_bileacids NA 0.314 no up up no no no Allograft rejection LCA+stool 0 -0.718181818 0 kegg stool_bileacids NA 0.314 no no no no no no Amphetamine addiction LCA+stool 0.566563467 0 0 kegg stool_bileacids NA 0.314 no no no no no no Antigen processing and presentation LCA+stool 0 -0.736363636 0 kegg stool_bileacids NA 0.314 no no no no no no Apoptosis LCA+stool -0.488132095 0 0 kegg stool_bileacids NA 0.314 no no no no no no Autoimmune thyroid disease LCA+stool 0 -0.718181818 0 kegg stool_bileacids NA 0.314 no no no no no no Autophagy - animal LCA+stool 0 0 0.440993789 kegg stool_bileacids NA 0.314 no no no no no no Axon guidance LCA+stool 0 0 0.460191982 kegg stool_bileacids NA 0.314 no up up no no no Bacterial invasion of epithelial cells LCA+stool 0 -0.672727273 0 kegg stool_bileacids NA 0.314 no no no no no no Biosynthesis of amino acids LCA+stool -0.473684211 -0.654545455 0 kegg stool_bileacids NA 0.314 no no no no no no CA+stool LCA+stool -0.628482972 -0.65034965 -0.444664032 stool_bileacids stool_bileacids 0.827 0.314 no no no no no no Carbon metabolism LCA+stool 0 -0.854545455 0 kegg stool_bileacids NA 0.314 no no no no no no CDCA+stool LCA+stool -0.667698658 -0.594405594 -0.480237154 stool_bileacids stool_bileacids 0.663 0.314 no no no no no no Cell adhesion molecules LCA+stool 0 -0.745454545 0 kegg stool_bileacids NA 0.314 no no no no no no Cellular senescence LCA+stool 0 -0.654545455 0 kegg stool_bileacids NA 0.314 no no no no no no Central carbon metabolism in cancer LCA+stool 0 0 0.447769622 kegg stool_bileacids NA 0.314 no no no no no no Chemical carcinogenesis - receptor activation LCA+stool 0 0.818181818 0 kegg stool_bileacids NA 0.314 no no no no no no Clostridium LCA+stool 0 -0.64942555 0 Genus stool_bileacids 0.925 0.314 no no no no no no Cocaine addiction LCA+stool 0 0.736363636 0 kegg stool_bileacids NA 0.314 no no no no no no Collinsella LCA+stool 0 0 -0.424891508 Genus stool_bileacids 0.128 0.314 no no no no no no Coprococcus LCA+stool 0 0 0.59486166 butyrate-producing Genus stool_bileacids 0.612 0.314 no no no no no no Cortisol synthesis and secretion LCA+stool 0 0.790909091 0 kegg stool_bileacids NA 0.314 no no up no no no Cushing syndrome LCA+stool 0 0.845454545 0 kegg stool_bileacids NA 0.314 no no up no no no DCA+stool LCA+stool 0.735810114 0.874125874 0.838932806 stool_bileacids stool_bileacids 0.195 0.314 no no no no no no Dorea LCA+stool -0.651186791 0 0 Genus stool_bileacids 0.00362 0.314 up no dn no no no Endocrine resistance LCA+stool 0.504643963 0.790909091 0 kegg stool_bileacids NA 0.314 no no no no no no Endocytosis LCA+stool -0.51496388 -0.781818182 0 kegg stool_bileacids NA 0.314 no no no no no no Epstein-Barr virus infection LCA+stool 0 -0.627272727 0 kegg stool_bileacids NA 0.314 no no no no no no Fc gamma R-mediated phagocytosis LCA+stool -0.469556244 -0.645454545 0 kegg stool_bileacids NA 0.314 no no no no no no Fluid shear stress and atherosclerosis LCA+stool 0 -0.754545455 0 kegg stool_bileacids NA 0.314 no no no no no no FoxO signaling pathway LCA+stool -0.475748194 0 0.704121965 kegg stool_bileacids NA 0.314 no no no no no no GABAergic synapse LCA+stool -0.490196078 0 0 kegg stool_bileacids NA 0.314 no up up no no no Gastric cancer LCA+stool 0 0 0.517786561 kegg stool_bileacids NA 0.314 no no no no no no GCA+stool LCA+stool 0 -0.818181818 0 stool_bileacids stool_bileacids 0.0809 0.314 no no no no no no GLCA+stool LCA+stool -0.643303768 0 0 stool_bileacids stool_bileacids 0.617 0.314 no no no no no no GnRH signaling pathway LCA+stool 0 0.781818182 0 kegg stool_bileacids NA 0.314 no no no no no no Graft-versus-host disease LCA+stool 0 -0.718181818 0 kegg stool_bileacids NA 0.314 no no no no no no "Growth hormone synthesis, secretion and action" LCA+stool 0 0.7 0 kegg stool_bileacids NA 0.314 no no no no no no HDCA+stool LCA+stool 0.498452012 0.685314685 0.589920949 stool_bileacids stool_bileacids 0.176 0.314 no no no no no no Herpes simplex virus 1 infection LCA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.314 no no no no no no Human cytomegalovirus infection LCA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.314 no no dn no no no Human immunodeficiency virus 1 infection LCA+stool 0 -0.627272727 0 kegg stool_bileacids NA 0.314 no no no no no no Human T-cell leukemia virus 1 infection LCA+stool 0 -0.690909091 0 kegg stool_bileacids NA 0.314 no no no no no no Insulin secretion LCA+stool 0 0.781818182 0 yes kegg stool_bileacids NA 0.314 no up up no no no iso-DCA+stool LCA+stool 0.636738906 0 0 stool_bileacids stool_bileacids 0.155 0.314 no no no no no no iso-LCA+stool LCA+stool 0.747547854 0.972027972 0.833992095 stool_bileacids stool_bileacids 0.72 0.314 no no no no no no JAK-STAT signaling pathway LCA+stool 0 0 0.426312818 kegg stool_bileacids NA 0.314 no no no no no no Leishmaniasis LCA+stool 0 -0.7 0 kegg stool_bileacids NA 0.314 no no no no no no Leukocyte transendothelial migration LCA+stool 0 -0.790909091 0 kegg stool_bileacids NA 0.314 no no no no no no Lysosome LCA+stool 0 -0.618181818 0 kegg stool_bileacids NA 0.314 no no no no no no MAPK signaling pathway LCA+stool 0 0 0.469226426 kegg stool_bileacids NA 0.314 no no no no no no MicroRNAs in cancer LCA+stool 0 0 0.481648786 kegg stool_bileacids NA 0.314 no no no no no no Morphine addiction LCA+stool 0 0.790909091 0 kegg stool_bileacids NA 0.314 no up up no no no mRNA surveillance pathway LCA+stool 0.488132095 0 0 kegg stool_bileacids NA 0.314 no no no no no no Natural killer cell mediated cytotoxicity LCA+stool 0 -0.736363636 0 kegg stool_bileacids NA 0.314 no no no no no no Neuroactive ligand-receptor interaction LCA+stool 0 -0.772727273 0 kegg stool_bileacids NA 0.314 up up up no no no Neutrophil extracellular trap formation LCA+stool -0.554179567 -0.672727273 0 kegg stool_bileacids NA 0.314 no no no no no no NOD-like receptor signaling pathway LCA+stool 0 0 0.532467532 kegg stool_bileacids NA 0.314 no no no no no no Odoribacter LCA+stool 0 -0.874125874 0 butyrate-producing Genus stool_bileacids 0.798 0.314 no no no no no no Olfactory transduction LCA+stool -0.510835913 0 0 kegg stool_bileacids NA 0.314 no no no no no no Oscillospira LCA+stool 0.531475748 0 0 LPS-producing Genus stool_bileacids 0.62 0.314 no no no no no no Osteoclast differentiation LCA+stool -0.479876161 0 0 kegg stool_bileacids NA 0.314 no no no no no no p53 signaling pathway LCA+stool 0 0.827272727 0 kegg stool_bileacids NA 0.314 no no no no no no Pancreatic cancer LCA+stool 0 0 0.730095991 kegg stool_bileacids NA 0.314 no no no no no no Pancreatic secretion LCA+stool 0 0.609090909 0 kegg stool_bileacids NA 0.314 no no no no no no Pathogenic Escherichia coli infection LCA+stool 0 -0.818181818 0 kegg stool_bileacids NA 0.314 no no no no no no Pathways in cancer LCA+stool 0 0.809090909 0.509881423 kegg stool_bileacids NA 0.314 no no no no no no Peroxisome LCA+stool -0.502579979 0 0 kegg stool_bileacids NA 0.314 no no no no no no Pertussis LCA+stool 0 -0.672727273 0 kegg stool_bileacids NA 0.314 no no dn no no no Phagosome LCA+stool 0 -0.8 0 kegg stool_bileacids NA 0.314 no no no no no no Platinum drug resistance LCA+stool 0 0 0.532467532 kegg stool_bileacids NA 0.314 no no no no no no Proteasome LCA+stool 0 -0.609090909 0 kegg stool_bileacids NA 0.314 no no no no no no Regulation of lipolysis in adipocytes LCA+stool 0 0.636363636 0 kegg stool_bileacids NA 0.314 no no no no no no Renal cell carcinoma LCA+stool 0 0 0.480519481 kegg stool_bileacids NA 0.314 no no no no no no Rheumatoid arthritis LCA+stool 0 -0.609090909 0 kegg stool_bileacids NA 0.314 no no no no no no RNA degradation LCA+stool 0.547987616 0 0 kegg stool_bileacids NA 0.314 no no no no no no Ruminococcus LCA+stool 0.616099071 0 0 acetate-producing Genus stool_bileacids 0.335 0.314 no no no no no no Salmonella infection LCA+stool 0 -0.863636364 0 kegg stool_bileacids NA 0.314 no no no no no no Serotonergic synapse LCA+stool 0 0.636363636 0 kegg stool_bileacids NA 0.314 no no no no no no Signaling pathways regulating pluripotency of stem cells LCA+stool 0 0.663636364 0.532467532 kegg stool_bileacids NA 0.314 no no no no no no Staphylococcus aureus infection LCA+stool 0 -0.645454545 0 kegg stool_bileacids NA 0.314 up no no no no no T cell receptor signaling pathway LCA+stool 0 0 0.495200452 kegg stool_bileacids NA 0.314 no no no no no no Thyroid hormone synthesis LCA+stool 0 0.636363636 0 kegg stool_bileacids NA 0.314 no no no no no no Tight junction LCA+stool 0 -0.709090909 0 kegg stool_bileacids NA 0.314 no no no no no no Tuberculosis LCA+stool 0 -0.7 0 kegg stool_bileacids NA 0.314 no no dn no no no Type I diabetes mellitus LCA+stool 0 -0.718181818 0 kegg stool_bileacids NA 0.314 no no no no no no Viral carcinogenesis LCA+stool -0.488132095 0 0 kegg stool_bileacids NA 0.314 no no no no no no Viral myocarditis LCA+stool 0 -0.754545455 0 kegg stool_bileacids NA 0.314 no no no no no no ¦Ø-MCA+stool LCA+stool -0.684300765 0 0 stool_bileacids stool_bileacids 0.919 0.314 no no no no no no ABC transporters Legionellosis 0.560869565 -0.450592885 -0.424453024 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes Legionellosis -0.422608696 0 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Legionellosis 0 -0.441699605 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Legionellosis -0.51826087 0 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Legionellosis 0.548695652 -0.513833992 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Legionellosis 0.595652174 -0.510869565 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Legionellosis 0.540869565 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Legionellosis -0.46 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Legionellosis 0 0.722332016 0.485714286 kegg kegg NA NA no no no no no no Bacteroides Legionellosis 0 0.491106719 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Base excision repair Legionellosis 0.410434783 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Legionellosis 0.428695652 0 0 kegg kegg NA NA no no no no no no Bile secretion Legionellosis -0.525217391 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Legionellosis 0.466956522 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Legionellosis 0.511304348 0 0.515315315 kegg kegg NA NA no no no no no no Calcium signaling pathway Legionellosis -0.552173913 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Legionellosis -0.448695652 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Legionellosis 0 0 -0.401801802 kegg kegg NA NA no no no no no no Carbon metabolism Legionellosis 0.499130435 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Legionellosis -0.407826087 0 0 kegg kegg NA NA no no up no no no Cholinergic synapse Legionellosis 0 0 -0.502702703 kegg kegg NA NA no no no no no no Cocaine addiction Legionellosis -0.447826087 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Legionellosis 0.437391304 0 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Legionellosis 0.597391304 0.533596838 0.46023166 kegg kegg NA NA no no no no no no Dopaminergic synapse Legionellosis -0.420869565 0 0 kegg kegg NA NA no up no no no no Dorea Legionellosis 0.476521739 0 0 Genus kegg 0.00362 NA up no dn no no no Drug metabolism - cytochrome P450 Legionellosis 0.528695652 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Legionellosis 0.472173913 0 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Legionellosis 0 0.781620553 0.552638353 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Legionellosis -0.570434783 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Legionellosis -0.587826087 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Legionellosis -0.43826087 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Legionellosis 0.448695652 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Legionellosis 0 0.416007905 0.436036036 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Legionellosis -0.586086957 0 -0.536164736 kegg kegg NA NA no no no no no no Folate biosynthesis Legionellosis 0 0 -0.443243243 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Legionellosis 0.510434783 -0.504940711 0 kegg kegg NA NA no no no no no no Galactose metabolism Legionellosis 0 -0.427865613 0 kegg kegg NA NA no no no no no no Gastric acid secretion Legionellosis -0.432173913 0 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Legionellosis -0.505217391 -0.43083004 0 kegg kegg NA NA no up up no no no Glycerolipid metabolism Legionellosis 0 -0.51284585 -0.414157014 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Legionellosis 0 -0.5256917 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Legionellosis 0.655652174 0.613636364 0.475933076 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Legionellosis 0 -0.433794466 -0.4002574 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Legionellosis -0.540869565 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Legionellosis 0 0 -0.401801802 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Legionellosis -0.513913043 0 0 kegg kegg NA NA no no no no no no GnRH secretion Legionellosis 0 0 -0.501673102 kegg kegg NA NA no up up no no no GnRH signaling pathway Legionellosis -0.480869565 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Legionellosis -0.552173913 -0.447628458 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Legionellosis -0.58 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Legionellosis 0.437391304 0.81027668 0.617760618 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Legionellosis 0 -0.592885375 -0.489060489 kegg kegg NA NA no no no no no no Homologous recombination Legionellosis 0.540869565 0 0 kegg kegg NA NA no no no no no no Huntington disease Legionellosis -0.431304348 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Legionellosis -0.46 0 0 kegg kegg NA NA no no no no no no Insulin secretion Legionellosis -0.495652174 0 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Legionellosis 0 0.738142292 0.474646075 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Legionellosis 0 -0.471343874 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Legionellosis 0.446956522 0 0 kegg kegg NA NA no no no no no no Long-term depression Legionellosis -0.66173913 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Legionellosis 0 0.451581028 0 kegg kegg NA NA no no up no no no Longevity regulating pathway - multiple species Legionellosis 0 0 0.451994852 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Legionellosis -0.579130435 -0.415019763 -0.493951094 kegg kegg NA NA no up no no no no Melanogenesis Legionellosis -0.466086957 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Legionellosis 0.499130435 0 0 kegg kegg NA NA no no no no no no Mismatch repair Legionellosis 0.493913043 0 0 kegg kegg NA NA no no no no no no Morphine addiction Legionellosis -0.527826087 0 0 kegg kegg NA NA no up up no no no mTOR signaling pathway Legionellosis 0 0.76284585 0.578893179 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Legionellosis 0.594782609 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Legionellosis -0.432173913 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Legionellosis 0.492173913 0 0.58996139 kegg kegg NA NA no no no no no no Notch signaling pathway Legionellosis -0.626086957 -0.429841897 -0.591248391 kegg kegg NA NA no no no no no no Odoribacter Legionellosis 0 0.440813635 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Other glycan degradation Legionellosis 0.555652174 0 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Legionellosis -0.464347826 0 0 kegg kegg NA NA no up up no no no Pancreatic secretion Legionellosis -0.576521739 0 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Legionellosis 0 -0.435770751 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Legionellosis 0.420869565 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Legionellosis -0.433913043 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Legionellosis -0.537391304 -0.559288538 -0.404375804 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Legionellosis 0.626086957 0.693675889 0.497297297 yes kegg kegg NA NA no up up no no no Primary bile acid biosynthesis Legionellosis 0.424347826 0 0 kegg kegg NA NA no no no no no no Prion disease Legionellosis 0 0.444664032 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Legionellosis -0.452173913 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Legionellosis 0.663478261 0.577075099 0.503989704 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Legionellosis 0 0 0.481338481 kegg kegg NA NA no no no no no no Pyrimidine metabolism Legionellosis 0.437391304 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Legionellosis 0.534782609 0.541501976 0.47001287 kegg kegg NA NA no no no no no no Ras signaling pathway Legionellosis 0 0 -0.436808237 yes kegg kegg NA NA no up up no no no Retinol metabolism Legionellosis 0.566086957 0 0 kegg kegg NA NA no no no no no no Ribosome Legionellosis 0 0.644268775 0.516344916 kegg kegg NA NA no no no no no no RNA transport Legionellosis 0.892173913 0.862648221 0.845817246 kegg kegg NA NA no no no no no no Salivary secretion Legionellosis -0.415652174 0 0 kegg kegg NA NA no no no no no no Shigellosis Legionellosis 0 0.416996047 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Legionellosis 0 -0.43083004 0 kegg kegg NA NA no no no no no no Spliceosome Legionellosis 0.524347826 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Legionellosis 0 -0.416996047 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Legionellosis 0.445217391 0 0 kegg kegg NA NA no no no no no no Taste transduction Legionellosis 0 0 -0.407464607 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Legionellosis 0 -0.450592885 0 kegg kegg NA NA no no no no no no Thermogenesis Legionellosis -0.466086957 0.422924901 0 kegg kegg NA NA no no no no no no Thiamine metabolism Legionellosis 0.577391304 0.5256917 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Legionellosis -0.48 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Legionellosis 0.43826087 0 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Legionellosis 0 0 -0.425740026 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Legionellosis 0.485217391 0 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Legionellosis -0.562608696 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Legionellosis -0.41826087 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Legionellosis -0.674782609 -0.486166008 -0.513770914 kegg kegg NA NA no no no no no no Wnt signaling pathway Legionellosis -0.539130435 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Leishmaniasis 0.514782609 0 0 kegg kegg NA NA no no no no no no ABC transporters Leishmaniasis 0.594782609 -0.610671937 -0.477220077 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes Leishmaniasis -0.659130435 0 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Leishmaniasis 0 -0.414031621 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Leishmaniasis -0.630434783 0 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Leishmaniasis -0.45826087 0 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Leishmaniasis 0.590434783 -0.4743083 0 kegg kegg NA NA no no no no no no Alzheimer disease Leishmaniasis -0.571304348 0 -0.400772201 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Leishmaniasis 0.629565217 -0.479249012 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Leishmaniasis 0.665217391 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Leishmaniasis -0.573043478 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Leishmaniasis -0.527826087 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Leishmaniasis 0 0 -0.462033462 kegg kegg NA NA no no no no no no Antigen processing and presentation Leishmaniasis 0 0.460474308 0.477220077 kegg kegg NA NA no no no no no no Apelin signaling pathway Leishmaniasis 0 0.654150198 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Leishmaniasis 0 -0.531620553 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Leishmaniasis 0 0.43083004 0 kegg kegg NA NA no no no no no no Bacteroides Leishmaniasis 0 0.499011858 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Base excision repair Leishmaniasis 0.429565217 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Leishmaniasis 0.6 0 0.452252252 kegg kegg NA NA no no no no no no Bile secretion Leishmaniasis -0.673913043 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Leishmaniasis 0.550434783 0 0.448391248 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Leishmaniasis 0.532173913 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Leishmaniasis 0.624347826 0.414031621 0.425740026 kegg kegg NA NA no no no no no no Butyricimonas Leishmaniasis -0.479143606 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no Calcium signaling pathway Leishmaniasis -0.65826087 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Leishmaniasis -0.656521739 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Leishmaniasis 0.602608696 0.588932806 0.45997426 kegg kegg NA NA no no no no no no Cardiac muscle contraction Leishmaniasis -0.530434783 0 0 kegg kegg NA NA no no up no no no Cholesterol metabolism Leishmaniasis 0 0.546442688 0 yes kegg kegg NA NA no no up no no no Cholinergic synapse Leishmaniasis 0 0 -0.456628057 kegg kegg NA NA no no no no no no Circadian entrainment Leishmaniasis -0.444347826 0 0 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Leishmaniasis 0.45826087 0 0 kegg kegg NA NA no no no no no no Cocaine addiction Leishmaniasis -0.48173913 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Leishmaniasis 0.425217391 0 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Leishmaniasis -0.513043478 0 0 kegg kegg NA NA no no up no no no Cushing syndrome Leishmaniasis -0.473043478 0 0 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Leishmaniasis 0.443478261 0.536561265 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Leishmaniasis -0.636521739 0 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Leishmaniasis 0.52173913 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Leishmaniasis 0.58 0.444664032 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Leishmaniasis 0 0.691699605 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Leishmaniasis -0.646086957 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Leishmaniasis -0.70173913 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Leishmaniasis -0.506086957 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Leishmaniasis 0.459130435 0 0 kegg kegg NA NA no no no no no no Fatty acid degradation Leishmaniasis 0.446086957 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Leishmaniasis 0.551304348 0.545454545 0.447619048 kegg kegg NA NA no no no no no no Fatty acid metabolism Leishmaniasis 0.548695652 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Leishmaniasis -0.477391304 0 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Leishmaniasis 0 0 0.406435006 kegg kegg NA NA no no no no no no Ferroptosis Leishmaniasis -0.426956522 0 0 kegg kegg NA NA no no no no no no Focal adhesion Leishmaniasis 0 0.43083004 0 kegg kegg NA NA no up up no no no Folate biosynthesis Leishmaniasis 0 0 -0.533590734 kegg kegg NA NA no no no no no no FoxO signaling pathway Leishmaniasis 0 -0.463438735 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Leishmaniasis 0.628695652 -0.468379447 0 kegg kegg NA NA no no no no no no Galactose metabolism Leishmaniasis 0.53826087 0 0 kegg kegg NA NA no no no no no no Gap junction Leishmaniasis 0 -0.467391304 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Leishmaniasis -0.547826087 -0.565217391 0 kegg kegg NA NA no up up no no no Glycerolipid metabolism Leishmaniasis 0 -0.595849802 -0.511196911 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Leishmaniasis 0 -0.672924901 -0.512483912 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Leishmaniasis 0.674782609 0.747035573 0.593307593 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Leishmaniasis 0 -0.476284585 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Leishmaniasis -0.549565217 0 -0.483140283 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Leishmaniasis -0.414782609 0 -0.418018018 kegg kegg NA NA no no no no no no GnRH secretion Leishmaniasis -0.444347826 0 -0.532818533 kegg kegg NA NA no up up no no no GnRH signaling pathway Leishmaniasis -0.53826087 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Leishmaniasis -0.633913043 -0.575098814 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Leishmaniasis -0.579130435 0 -0.411583012 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Leishmaniasis 0 0.442687747 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Leishmaniasis 0 0.790513834 0.491891892 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Leishmaniasis 0 -0.566205534 -0.420592021 kegg kegg NA NA no no no no no no Homologous recombination Leishmaniasis 0.52 0 0 kegg kegg NA NA no no no no no no Huntington disease Leishmaniasis -0.546956522 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Leishmaniasis -0.640869565 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Leishmaniasis 0 0 -0.464607465 kegg kegg NA NA no no no no no no Insulin secretion Leishmaniasis -0.51826087 0 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Leishmaniasis 0 0.664031621 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Leishmaniasis 0 0.463438735 0.428571429 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Leishmaniasis 0 -0.559288538 0 kegg kegg NA NA no no no no no no Legionellosis Leishmaniasis 0.874782609 0.93083004 0.932818533 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Leishmaniasis 0 0.509881423 0 kegg kegg NA NA no no no no no no Long-term depression Leishmaniasis -0.749565217 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Leishmaniasis 0 0.463438735 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Leishmaniasis -0.508695652 -0.459486166 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Leishmaniasis 0 0 0.41981982 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Leishmaniasis 0 0 -0.511454311 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Leishmaniasis -0.45826087 -0.419960474 -0.508365508 kegg kegg NA NA no up no no no no Melanogenesis Leishmaniasis -0.567826087 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Leishmaniasis 0.528695652 0 0 kegg kegg NA NA no no no no no no Mineral absorption Leishmaniasis -0.539130435 0 0 kegg kegg NA NA no no no no no no Mismatch repair Leishmaniasis 0.547826087 0 0 kegg kegg NA NA no no no no no no Morphine addiction Leishmaniasis -0.637391304 0 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Leishmaniasis -0.446956522 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Leishmaniasis 0 0.671936759 0.416473616 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Leishmaniasis 0.502608696 0 0 kegg kegg NA NA no no no no no no Necroptosis Leishmaniasis -0.480869565 0 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Leishmaniasis 0 -0.471343874 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Leishmaniasis -0.617391304 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Leishmaniasis 0.597391304 0.526679842 0.502187902 kegg kegg NA NA no no no no no no Notch signaling pathway Leishmaniasis -0.566086957 -0.503952569 -0.66023166 kegg kegg NA NA no no no no no no Nucleotide excision repair Leishmaniasis 0.420869565 0 0 kegg kegg NA NA no no no no no no Odoribacter Leishmaniasis 0 0.593364871 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Oocyte meiosis Leishmaniasis 0 0.470355731 0 kegg kegg NA NA no no no no no no Other glycan degradation Leishmaniasis 0.645217391 -0.429841897 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Leishmaniasis 0 -0.449604743 -0.438867439 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Leishmaniasis -0.553913043 0 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Leishmaniasis -0.535652174 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Leishmaniasis 0 -0.576086957 0 kegg kegg NA NA no no no no no no Pancreatic secretion Leishmaniasis -0.684347826 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Leishmaniasis -0.487826087 0 0 kegg kegg NA NA no no no no no no Parkinson disease Leishmaniasis -0.546086957 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Leishmaniasis -0.533913043 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Leishmaniasis 0.447826087 0 0 kegg kegg NA NA no no no no no no Peroxisome Leishmaniasis 0 0 0.420849421 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Leishmaniasis -0.469565217 0 -0.503474903 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Leishmaniasis -0.573043478 -0.59486166 0 kegg kegg NA NA no up up no no no Phototransduction Leishmaniasis 0 0.513833992 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Leishmaniasis 0.414782609 0.493083004 0 yes kegg kegg NA NA no up up no no no Platinum drug resistance Leishmaniasis 0 -0.479249012 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Leishmaniasis 0.53826087 0 0 kegg kegg NA NA no no no no no no Prion disease Leishmaniasis -0.50173913 0.42687747 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Leishmaniasis -0.58173913 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Leishmaniasis 0.548695652 0.578063241 0 kegg kegg NA NA no no no no no no Proteasome Leishmaniasis 0 0.480237154 0 kegg kegg NA NA no no no no no no Protein export Leishmaniasis 0 0.416996047 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Leishmaniasis 0.602608696 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Leishmaniasis 0.463478261 0.510869565 0 kegg kegg NA NA no no no no no no Ras signaling pathway Leishmaniasis 0 0 -0.54980695 yes kegg kegg NA NA no up up no no no Regulation of lipolysis in adipocytes Leishmaniasis -0.651304348 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Leishmaniasis -0.412173913 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Leishmaniasis 0.553043478 0 0 kegg kegg NA NA no no no no no no Ribosome Leishmaniasis 0 0.579051383 0 kegg kegg NA NA no no no no no no RNA transport Leishmaniasis 0.756521739 0.804347826 0.705276705 kegg kegg NA NA no no no no no no Salmonella infection Leishmaniasis 0 0.453557312 0.414414414 kegg kegg NA NA no no no no no no Selenocompound metabolism Leishmaniasis 0 -0.421936759 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Leishmaniasis -0.413043478 0 -0.437580438 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Leishmaniasis 0.517391304 -0.503952569 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Leishmaniasis -0.556521739 0 0 kegg kegg NA NA no no no no no no Spliceosome Leishmaniasis 0.412173913 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Leishmaniasis 0.44173913 0 0 kegg kegg NA NA no no no no no no Taste transduction Leishmaniasis 0 0 -0.518661519 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Leishmaniasis 0 -0.605731225 -0.435521236 kegg kegg NA NA no no no no no no Thermogenesis Leishmaniasis -0.572173913 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Leishmaniasis 0.553913043 0.4743083 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Leishmaniasis 0.570434783 0 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Leishmaniasis 0 -0.479249012 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Leishmaniasis 0.510434783 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Leishmaniasis 0.576521739 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Leishmaniasis -0.554782609 0 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Leishmaniasis -0.666956522 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Leishmaniasis -0.503478261 0 -0.421879022 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Leishmaniasis -0.7 -0.427865613 -0.567567568 kegg kegg NA NA no no no no no no Wnt signaling pathway Leishmaniasis -0.54 0 -0.468211068 kegg kegg NA NA no no no no no no 13-HODE+blood Leptin 0 -0.674019608 0 serum_ARA DM-assocaited hormones 0.32 0.706 no no no no no no 14:0/18:2-PC+blood Leptin 0.605779154 0 0 serum_phospholipids DM-assocaited hormones 0.102 0.706 no up no no no no 16:0/16:1-PC+blood Leptin 0 0 0.447826087 serum_phospholipids DM-assocaited hormones 0.00283 0.706 up up no no no no 16:0/18:2-PI+blood Leptin 0 0 0.530434783 serum_phospholipids DM-assocaited hormones 0.269 0.706 no no no no no no 16:0/18:3-PC+blood Leptin 0.539731682 0 0 serum_phospholipids DM-assocaited hormones 0.00216 0.706 no up up no no no 16:0/20:4-PC+blood Leptin 0 -0.507352941 0 serum_phospholipids DM-assocaited hormones 0.0262 0.706 no up no no no no 16:0/20:4-PI+blood Leptin 0 0.585784314 0.468695652 serum_phospholipids DM-assocaited hormones 0.558 0.706 no no no no no no 16:0/20:5-PC+blood Leptin 0.570691434 0 0 serum_phospholipids DM-assocaited hormones 0.628 0.706 no no no no no no 16:0+blood Leptin 0 -0.558823529 0 yes serum_fattyacid DM-assocaited hormones 0.00876 0.706 up no no no no no 18:0/18:0-PC+blood Leptin 0 0.671568627 0 serum_phospholipids DM-assocaited hormones 0.426 0.706 no no no no no no 18:0/18:0-PS+blood Leptin 0 0.5 0 serum_phospholipids DM-assocaited hormones 0.00617 0.706 no up no no no no 18:0/18:1-PC+blood Leptin 0 0.68627451 0 serum_phospholipids DM-assocaited hormones 0.393 0.706 no no no no no no 18:0/18:1-PE+blood Leptin 0 0.504901961 0 serum_phospholipids DM-assocaited hormones 0.00716 0.706 up up no no no no 18:0/20:2-PC+blood Leptin 0 0.5 0 serum_phospholipids DM-assocaited hormones 0.733 0.706 no no no no no no 18:0/20:3-PC+blood Leptin 0 0.727941176 0 serum_phospholipids DM-assocaited hormones 0.0682 0.706 no up no no no no 18:0/20:4-PI+blood Leptin -0.59752322 0 0 serum_phospholipids DM-assocaited hormones 0.167 0.706 no no no no no no 18:0/22:6-PC+blood Leptin 0.599587203 0 0 serum_phospholipids DM-assocaited hormones 0.0775 0.706 no no up no no no 18:1-LPC+blood Leptin -0.614035088 0 0 serum_phospholipids DM-assocaited hormones 0.179 0.706 no no no no no no 18:2-LPC+blood Leptin 0 -0.644607843 0 serum_phospholipids DM-assocaited hormones 0.00743 0.706 dn no up no no no 18:2/16:0-PC+blood Leptin 0 -0.62745098 0 serum_phospholipids DM-assocaited hormones 8.67E-05 0.706 no up up no no no 18:3n6+blood Leptin 0 0 0.493913043 serum_fattyacid DM-assocaited hormones 0.0463 0.706 up no dn no no no 20:2/18:0-PC+blood Leptin 0.479876161 0.735294118 0 serum_phospholipids DM-assocaited hormones 0.0427 0.706 no up no no no no 20:3/16:0-PC+blood Leptin 0 -0.526960784 0 serum_phospholipids DM-assocaited hormones 0.00405 0.706 no up up no no no 20:3n6+blood Leptin 0 0.487745098 0 serum_fattyacid DM-assocaited hormones 0.0884 0.706 up no no no no no 20:4-LPC+blood Leptin 0 -0.56372549 0 serum_phospholipids DM-assocaited hormones 0.949 0.706 no no no no no no 20:4n6+blood Leptin 0 -0.556372549 0 serum_fattyacid DM-assocaited hormones 0.133 0.706 no no no no no no 20:5n3+blood Leptin 0.55624355 0 0 serum_fattyacid DM-assocaited hormones 0.988 0.706 no no no no no no 22:6n3+blood Leptin 0.634674923 0 0 serum_fattyacid DM-assocaited hormones 0.792 0.706 no no no no no no 8-HETE+blood Leptin 0 -0.656862745 0 serum_ARA DM-assocaited hormones 0.741 0.706 no no no no no no 9-HODE+blood Leptin 0 -0.50245098 0 serum_ARA DM-assocaited hormones 0.297 0.706 no no no no no no AA+blood Leptin 0 -0.568627451 0 serum_ARA DM-assocaited hormones 0.212 0.706 no no no no no no Alistipes Leptin -0.478951444 0 0 Genus DM-assocaited hormones 0.0114 0.706 no up no no no no Alzheimer disease Leptin -0.438735178 0 0 kegg DM-assocaited hormones NA 0.706 no no no no no no Amyotrophic lateral sclerosis Leptin -0.453416149 0 0 kegg DM-assocaited hormones NA 0.706 no no no no no no Betaine+blood Leptin -0.473684211 -0.649509804 -0.411304348 serum_choline DM-assocaited hormones 0.857 0.706 no no no no no no Biosynthesis of cofactors Leptin 0 0.455533597 0 kegg DM-assocaited hormones NA 0.706 no no no no no no Butyric acid+stool Leptin 0 0 -0.445454545 yes stool_scfa DM-assocaited hormones 0.102 0.706 dn no no no no no cAMP signaling pathway Leptin 0 -0.5 0 yes kegg DM-assocaited hormones NA 0.706 no up up no no no Cardiac muscle contraction Leptin -0.43083004 0 0 kegg DM-assocaited hormones NA 0.706 no no up no no no CDCA+blood Leptin 0 0 0.424347826 serum_bileacids DM-assocaited hormones 0.506 0.706 no no no no no no CDCA+stool Leptin 0.632352941 0 0 stool_bileacids DM-assocaited hormones 0.663 0.706 no no no no no no Central carbon metabolism in cancer Leptin 0 0.467391304 0 kegg DM-assocaited hormones NA 0.706 no no no no no no Choline+blood Leptin 0 -0.50245098 0 serum_choline DM-assocaited hormones 0.0395 0.706 no up no no no no Cocaine addiction Leptin 0 0 0.415106952 kegg DM-assocaited hormones NA 0.706 no no no no no no Coprococcus Leptin 0.436758893 0 0 butyrate-producing Genus DM-assocaited hormones 0.612 0.706 no no no no no no Creatinine+blood Leptin -0.492260062 0 0 serum_choline DM-assocaited hormones 0.437 0.706 no no no no no no DHA+blood Leptin 0 -0.639705882 0 serum_ARA DM-assocaited hormones 0.872 0.706 no no no no no no Diabetic cardiomyopathy Leptin -0.440993789 0 0 kegg DM-assocaited hormones NA 0.706 no no no no no no DL-Indole-3-lactic acid+urine Leptin 0 -0.531578947 0 urine_cometabolism DM-assocaited hormones 0.00552 0.706 up up no no no no DPA+blood Leptin 0 -0.575980392 0 serum_ARA DM-assocaited hormones 0.519 0.706 no no no no no no Faecalibacterium Leptin 0 0 0.406587346 butyrate-producing Genus DM-assocaited hormones 0.0039 0.706 no dn dn no no no Gap junction Leptin 0 -0.43972332 0 kegg DM-assocaited hormones NA 0.706 no no no no no no GCA+stool Leptin 0.520588235 0 0 stool_bileacids DM-assocaited hormones 0.0809 0.706 no no no no no no GCDCA+stool Leptin 0 0 0.445454545 yes stool_bileacids DM-assocaited hormones 0.0471 0.706 no dn no no no no GLCA+blood Leptin 0 0 -0.417028828 serum_bileacids DM-assocaited hormones 0.319 0.706 no no no no no no GLP-1 Leptin -0.497035573 0 0 DM-assocaited hormones DM-assocaited hormones 0.256 0.706 no no no no no no Glucagon Leptin -0.649209486 -0.42173913 0 DM-assocaited hormones DM-assocaited hormones 0.0283 0.706 no no up no no no "Glycine, serine and threonine metabolism" Leptin 0 0.419960474 0 kegg DM-assocaited hormones NA 0.706 no up no no no no GUDCA+blood Leptin 0 0.507352941 0 serum_bileacids DM-assocaited hormones 0.0766 0.706 no no dn no no no HCA+blood Leptin 0 0 0.43953907 serum_bileacids DM-assocaited hormones 0.544 0.706 no no no no no no Human papillomavirus infection Leptin 0.426312818 0 0.44618984 kegg DM-assocaited hormones NA 0.706 no no no no no no Huntington disease Leptin -0.451157538 0 0 kegg DM-assocaited hormones NA 0.706 no no no no no no Hypotaurine+blood Leptin -0.595459236 -0.551470588 -0.526956522 serum_aminoacids DM-assocaited hormones 0.933 0.706 no no no no no no IP-10 Leptin 0 0.611688312 0 serum_cytokines DM-assocaited hormones 0.394 0.706 no no no no no no iso-LCA+stool Leptin -0.609271688 0 0 stool_bileacids DM-assocaited hormones 0.72 0.706 no no no no no no L-Citrulline+blood Leptin 0 0 -0.452173913 serum_aminoacids DM-assocaited hormones 0.534 0.706 no no no no no no L-Homocystine+blood Leptin 0 0 -0.447826087 serum_aminoacids DM-assocaited hormones 0.197 0.706 no no no no no no L-Methionine+blood Leptin 0 0 -0.56173913 serum_aminoacids DM-assocaited hormones 0.626 0.706 no no no no no no L-Phenylalanine+stool Leptin -0.538235294 0 0 stool_cometabolism DM-assocaited hormones 0.398 0.706 no no no no no no L-Tryptophan+blood Leptin 0 0 -0.460869565 serum_aminoacids DM-assocaited hormones 0.164 0.706 no no no no no no L-Tyrosine+blood Leptin 0 0.539215686 0 yes serum_aminoacids DM-assocaited hormones 0.00913 0.706 up up no no no no Long-term depression Leptin 0 -0.546442688 0 kegg DM-assocaited hormones NA 0.706 no no no no no no n3+blood Leptin 0.684210526 0 0 serum_fattyacid DM-assocaited hormones 0.806 0.706 no no no no no no n6/n3+blood Leptin -0.673890609 0 0 serum_fattyacid DM-assocaited hormones 0.226 0.706 no no no no no no nutriCA+stool Leptin 0 0.76058224 0 stool_bileacids DM-assocaited hormones 0.481 0.706 no no no no no no Oxidative phosphorylation Leptin -0.459062676 0 0 kegg DM-assocaited hormones NA 0.706 no no no no no no P-hydroxyhippuric acid+urine Leptin 0.477812178 0 0 urine_cometabolism DM-assocaited hormones 0.436 0.706 no no no no no no PDGF-bb Leptin 0 -0.675324675 0 yes serum_cytokines DM-assocaited hormones 0.111 0.706 no no no no no no Phenylacetic acid+stool Leptin -0.685294118 0 0 stool_cometabolism DM-assocaited hormones 0.785 0.706 no no no no no no Phenylacetyl L-GlutaMine+urine Leptin 0 -0.457894737 0 urine_cometabolism DM-assocaited hormones 0.0909 0.706 up no no no no no Porphyrin and chlorophyll metabolism Leptin 0 0.511857708 0 kegg DM-assocaited hormones NA 0.706 no no no no no no PUFA/MUFA+blood Leptin 0 -0.585784314 0 serum_fattyacid DM-assocaited hormones 0.00108 0.706 dn no up no no no PUFA%+blood Leptin 0 -0.573529412 0 serum_fattyacid DM-assocaited hormones 0.0013 0.706 dn no up no no no Purine metabolism Leptin 0 0.437747036 0 kegg DM-assocaited hormones NA 0.706 no no no no no no Relaxin signaling pathway Leptin 0 -0.501976285 0 kegg DM-assocaited hormones NA 0.706 no no no no no no Ruminococcus Leptin 0 0.511304348 0 acetate-producing Genus DM-assocaited hormones 0.335 0.706 no no no no no no Salivary secretion Leptin 0 -0.420948617 0 kegg DM-assocaited hormones NA 0.706 no no no no no no Sarcosine+blood Leptin 0 0 0.486956522 serum_choline DM-assocaited hormones 5.06E-05 0.706 up up no no no no Serotonergic synapse Leptin 0 -0.459486166 0 kegg DM-assocaited hormones NA 0.706 no no no no no no Thermogenesis Leptin -0.470355731 0 0 kegg DM-assocaited hormones NA 0.706 no no no no no no total_stool_scfa+stool Leptin 0 0 -0.522077922 stool_scfa DM-assocaited hormones 0.0534 0.706 dn no up no no no UDCA+blood Leptin 0 0 0.450545732 yes serum_bileacids DM-assocaited hormones 0.0939 0.706 no no dn no no no ABC transporters Leukocyte transendothelial migration 0 -0.791501976 -0.428828829 kegg kegg NA NA no up up no no no Adherens junction Leukocyte transendothelial migration 0.766086957 0.722332016 0.723809524 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Leukocyte transendothelial migration 0 -0.583003953 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Leukocyte transendothelial migration 0 0.585968379 0.421621622 kegg kegg NA NA no no no no no no Apelin signaling pathway Leukocyte transendothelial migration -0.489565217 0 0 kegg kegg NA NA no no no no no no Apoptosis Leukocyte transendothelial migration 0.628695652 0 0.631917632 kegg kegg NA NA no no no no no no Apoptosis - multiple species Leukocyte transendothelial migration -0.700869565 -0.806324111 -0.415701416 kegg kegg NA NA no no no no no no Autophagy - animal Leukocyte transendothelial migration 0 -0.441699605 0 kegg kegg NA NA no no no no no no Autophagy - other Leukocyte transendothelial migration -0.660869565 -0.708498024 -0.476447876 kegg kegg NA NA no no no no no no Axon guidance Leukocyte transendothelial migration 0 0.658102767 0 kegg kegg NA NA no up up no no no Basal transcription factors Leukocyte transendothelial migration -0.760869565 -0.443675889 -0.609009009 kegg kegg NA NA no no no no no no Base excision repair Leukocyte transendothelial migration -0.72 -0.551383399 -0.486743887 kegg kegg NA NA no no no no no no Bifidobacterium Leukocyte transendothelial migration 0 0.445766597 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Biosynthesis of amino acids Leukocyte transendothelial migration 0.431304348 0 0.572715573 kegg kegg NA NA no no no no no no Butyricicoccus Leukocyte transendothelial migration -0.482818593 0 0 butyrate-producing Genus kegg 0.852 NA no no no no no no Carbon metabolism Leukocyte transendothelial migration 0 0.730237154 0.592792793 kegg kegg NA NA no no no no no no Cell adhesion molecules Leukocyte transendothelial migration 0.586086957 0.466403162 0.569111969 kegg kegg NA NA no no no no no no Cell cycle Leukocyte transendothelial migration -0.54 0 -0.494208494 kegg kegg NA NA no no no no no no Cellular senescence Leukocyte transendothelial migration 0.494782609 0 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Leukocyte transendothelial migration 0.476521739 0 0.547232947 kegg kegg NA NA no no no no no no Clostridium Leukocyte transendothelial migration 0 0.536910485 0 Genus kegg 0.925 NA no no no no no no Complement and coagulation cascades Leukocyte transendothelial migration 0.442608696 0 0.754440154 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Leukocyte transendothelial migration 0 0 0.576319176 kegg kegg NA NA no no no no no no DNA replication Leukocyte transendothelial migration -0.527826087 0 -0.468725869 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Leukocyte transendothelial migration -0.489565217 0 0 kegg kegg NA NA no no no no no no Endocytosis Leukocyte transendothelial migration 0.586956522 0.475296443 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Leukocyte transendothelial migration -0.566956522 -0.653162055 -0.509137709 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration 0 0 0.552123552 kegg kegg NA NA no no no no no no Focal adhesion Leukocyte transendothelial migration 0.823478261 0.740118577 0.718918919 kegg kegg NA NA no up up no no no FoxO signaling pathway Leukocyte transendothelial migration 0 -0.56916996 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Leukocyte transendothelial migration 0 -0.485177866 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Leukocyte transendothelial migration 0 -0.710474308 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Leukocyte transendothelial migration -0.667826087 -0.882411067 -0.554954955 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Leukocyte transendothelial migration 0 0.532608696 0.406177606 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Leukocyte transendothelial migration 0.467826087 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Leukocyte transendothelial migration 0.486956522 0 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Leukocyte transendothelial migration -0.49826087 -0.759881423 -0.468983269 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Leukocyte transendothelial migration 0 -0.510869565 -0.500643501 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Leukocyte transendothelial migration -0.502608696 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Leukocyte transendothelial migration 0.66 0.592885375 0.637837838 kegg kegg NA NA no no no no no no Homologous recombination Leukocyte transendothelial migration -0.471304348 -0.816205534 -0.544144144 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Leukocyte transendothelial migration 0 -0.746047431 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Leukocyte transendothelial migration 0 -0.57312253 0 kegg kegg NA NA no no no no no no Lachnospira Leukocyte transendothelial migration 0 0.574746744 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Longevity regulating pathway Leukocyte transendothelial migration 0 -0.626482213 0 kegg kegg NA NA no no no no no no Lysine degradation Leukocyte transendothelial migration -0.577391304 -0.70256917 -0.588159588 kegg kegg NA NA no no no no no no Lysosome Leukocyte transendothelial migration 0.44173913 0.606719368 0.427541828 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Leukocyte transendothelial migration 0 -0.518774704 -0.502187902 kegg kegg NA NA no no no no no no MAPK signaling pathway Leukocyte transendothelial migration 0 -0.589920949 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Leukocyte transendothelial migration -0.516521739 0 -0.565508366 kegg kegg NA NA no no no no no no mTOR signaling pathway Leukocyte transendothelial migration -0.467826087 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Leukocyte transendothelial migration 0 -0.48715415 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Leukocyte transendothelial migration -0.429565217 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Leukocyte transendothelial migration 0.636521739 0.455533597 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Leukocyte transendothelial migration 0 0.480237154 0.587387387 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Leukocyte transendothelial migration 0.606086957 0.456521739 0.687258687 kegg kegg NA NA no no no no no no Nucleotide excision repair Leukocyte transendothelial migration -0.54173913 0 0 kegg kegg NA NA no no no no no no One carbon pool by folate Leukocyte transendothelial migration -0.447826087 0 0 kegg kegg NA NA no no no no no no Other glycan degradation Leukocyte transendothelial migration 0 -0.650197628 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Leukocyte transendothelial migration -0.726956522 -0.804347826 -0.634234234 kegg kegg NA NA no no no no no no p53 signaling pathway Leukocyte transendothelial migration -0.787826087 -0.934782609 -0.738996139 kegg kegg NA NA no no no no no no Pentose phosphate pathway Leukocyte transendothelial migration 0.564347826 0.495059289 0 kegg kegg NA NA no no no no no no Phagosome Leukocyte transendothelial migration 0.659130435 0.593873518 0.683912484 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Leukocyte transendothelial migration 0 0 -0.514543115 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Leukocyte transendothelial migration -0.433913043 0 0 yes kegg kegg NA NA no up up no no no Platelet activation Leukocyte transendothelial migration 0.769565217 0.735177866 0.76962677 kegg kegg NA NA no no no no no no Platinum drug resistance Leukocyte transendothelial migration -0.660869565 -0.751976285 -0.424453024 kegg kegg NA NA no no no no no no Protein export Leukocyte transendothelial migration -0.636521739 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Leukocyte transendothelial migration -0.46173913 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Leukocyte transendothelial migration 0 0 -0.528700129 kegg kegg NA NA no no no no no no Rap1 signaling pathway Leukocyte transendothelial migration 0.890434783 0.751976285 0.794337194 kegg kegg NA NA no no no no no no Renin-angiotensin system Leukocyte transendothelial migration 0 0 0.458687259 kegg kegg NA NA no no no no no no Ribosome Leukocyte transendothelial migration -0.407826087 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Leukocyte transendothelial migration -0.711304348 -0.42687747 -0.540540541 kegg kegg NA NA no no no no no no RNA degradation Leukocyte transendothelial migration -0.444347826 0 -0.509395109 kegg kegg NA NA no no no no no no RNA polymerase Leukocyte transendothelial migration -0.785217391 0 -0.411840412 kegg kegg NA NA no no no no no no Selenocompound metabolism Leukocyte transendothelial migration -0.797391304 -0.713438735 -0.577863578 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Leukocyte transendothelial migration 0 -0.479249012 -0.403861004 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Leukocyte transendothelial migration -0.440869565 -0.640316206 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Leukocyte transendothelial migration 0.47826087 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Leukocyte transendothelial migration 0 0.457509881 0 kegg kegg NA NA no no no no no no Spliceosome Leukocyte transendothelial migration -0.729565217 -0.821146245 -0.581724582 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Leukocyte transendothelial migration 0 -0.498023715 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Leukocyte transendothelial migration -0.526086957 -0.735177866 -0.532046332 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Leukocyte transendothelial migration -0.531304348 0 0 kegg kegg NA NA no no no no no no Tight junction Leukocyte transendothelial migration 0.619130435 0.769762846 0.627541828 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Leukocyte transendothelial migration 0.434782609 0.472332016 0.567824968 kegg kegg NA NA no no no no no no Wnt signaling pathway Leukocyte transendothelial migration 0 0 -0.411840412 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Linoleic acid metabolism 0.413913043 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Linoleic acid metabolism 0.443478261 0.462450593 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Linoleic acid metabolism 0.426086957 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Linoleic acid metabolism 0 0 0.452252252 kegg kegg NA NA no no no no no no Glutathione metabolism Linoleic acid metabolism 0.446956522 0 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Linoleic acid metabolism 0.467826087 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Linoleic acid metabolism 0.493913043 0 0.484169884 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Linoleic acid metabolism 0 0 0.414157014 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Linoleic acid metabolism 0 -0.423913043 0 kegg kegg NA NA no no up no no no Pentose and glucuronate interconversions Linoleic acid metabolism 0.616521739 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Linoleic acid metabolism 0.509565217 0.45256917 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Linoleic acid metabolism 0 0.459486166 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Linoleic acid metabolism 0.408695652 0 0.418532819 kegg kegg NA NA no no no no no no Tyrosine metabolism Linoleic acid metabolism 0 0.479249012 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Lipid and atherosclerosis 0 -0.497035573 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Lipid and atherosclerosis 0 0.455533597 0 kegg kegg NA NA no no no no no no Adherens junction Lipid and atherosclerosis 0 -0.416996047 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Lipid and atherosclerosis 0 -0.79743083 -0.494723295 kegg kegg NA NA no no up no no no African trypanosomiasis Lipid and atherosclerosis 0 0.518774704 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Lipid and atherosclerosis 0 0.735177866 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Lipid and atherosclerosis 0.608695652 0.770750988 0.552895753 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Lipid and atherosclerosis -0.52173913 -0.887351779 -0.521750322 kegg kegg NA NA no up up no no no Alistipes Lipid and atherosclerosis -0.427951679 0 0 Genus kegg 0.0114 NA no up no no no no Allograft rejection Lipid and atherosclerosis 0 0.585968379 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Lipid and atherosclerosis 0 0.638339921 0 kegg kegg NA NA no no no no no no Alzheimer disease Lipid and atherosclerosis 0 -0.770750988 -0.418275418 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Lipid and atherosclerosis 0 0 -0.466409266 kegg kegg NA NA no no no no no no Amoebiasis Lipid and atherosclerosis 0 0.625494071 0.434491634 kegg kegg NA NA no no no no no no Amphetamine addiction Lipid and atherosclerosis -0.466956522 -0.860671937 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Lipid and atherosclerosis -0.743478261 -0.633399209 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Lipid and atherosclerosis 0 -0.817193676 -0.435263835 kegg kegg NA NA no no no no no no Antifolate resistance Lipid and atherosclerosis 0 -0.537549407 -0.423938224 kegg kegg NA NA no no no no no no Antigen processing and presentation Lipid and atherosclerosis 0 0 0.588159588 kegg kegg NA NA no no no no no no Apelin signaling pathway Lipid and atherosclerosis 0 -0.679841897 0 kegg kegg NA NA no no no no no no Apoptosis Lipid and atherosclerosis 0.451304348 0.778656126 0.657400257 kegg kegg NA NA no no no no no no Apoptosis - multiple species Lipid and atherosclerosis 0 0 -0.448391248 kegg kegg NA NA no no no no no no Arginine and proline metabolism Lipid and atherosclerosis 0.683478261 0.791501976 0.612355212 kegg kegg NA NA no up no no no no Arginine biosynthesis Lipid and atherosclerosis 0.643478261 0.782608696 0.64041184 kegg kegg NA NA no no no no no no Arrhythmogenic right ventricular cardiomyopathy Lipid and atherosclerosis 0 -0.509881423 0 kegg kegg NA NA no up up no no no Autoimmune thyroid disease Lipid and atherosclerosis 0 0.585968379 0 kegg kegg NA NA no no no no no no Autophagy - animal Lipid and atherosclerosis 0.505217391 0.588932806 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Lipid and atherosclerosis 0 0.721343874 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Lipid and atherosclerosis -0.526956522 -0.588932806 -0.537194337 kegg kegg NA NA no no no no no no Basal transcription factors Lipid and atherosclerosis 0 -0.532608696 -0.615444015 kegg kegg NA NA no no no no no no Base excision repair Lipid and atherosclerosis 0 -0.52173913 -0.612870013 kegg kegg NA NA no no no no no no Bile secretion Lipid and atherosclerosis -0.413913043 -0.495059289 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Lipid and atherosclerosis 0 0.874505929 0.793822394 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Lipid and atherosclerosis -0.597391304 -0.618577075 0 kegg kegg NA NA no no no no no no Bladder cancer Lipid and atherosclerosis 0.853043478 0.741106719 0.703474903 kegg kegg NA NA no no no no no no Butanoate metabolism Lipid and atherosclerosis 0 -0.477272727 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Lipid and atherosclerosis 0.451304348 0.745059289 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Lipid and atherosclerosis 0 -0.686758893 -0.45045045 kegg kegg NA NA no up up no no no Carbon metabolism Lipid and atherosclerosis 0 0 0.645559846 kegg kegg NA NA no no no no no no Cardiac muscle contraction Lipid and atherosclerosis 0 -0.767786561 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Lipid and atherosclerosis 0 0.675889328 0.519176319 kegg kegg NA NA no no no no no no Cell cycle Lipid and atherosclerosis 0 -0.779644269 -0.721492921 kegg kegg NA NA no no no no no no Cellular senescence Lipid and atherosclerosis 0 0.638339921 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Lipid and atherosclerosis 0.673913043 0.867588933 0.649420849 kegg kegg NA NA no no no no no no Chagas disease Lipid and atherosclerosis 0 0.557312253 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Lipid and atherosclerosis 0.42 0.567193676 0.537451737 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Lipid and atherosclerosis 0 -0.530632411 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Lipid and atherosclerosis 0 0.595849802 0.601801802 kegg kegg NA NA no no no no no no Cholesterol metabolism Lipid and atherosclerosis 0 0.564229249 0.5003861 yes kegg kegg NA NA no no up no no no Circadian entrainment Lipid and atherosclerosis 0 -0.527667984 0 kegg kegg NA NA no up up no no no Circadian rhythm Lipid and atherosclerosis 0 -0.685770751 -0.6 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Lipid and atherosclerosis 0 -0.444664032 0 kegg kegg NA NA no no no no no no Cocaine addiction Lipid and atherosclerosis -0.60173913 -0.610671937 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Lipid and atherosclerosis 0 0.78458498 0.641698842 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Lipid and atherosclerosis -0.543478261 -0.665019763 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Lipid and atherosclerosis -0.62 -0.664031621 0 kegg kegg NA NA no no up no no no Cushing syndrome Lipid and atherosclerosis -0.693913043 -0.772727273 -0.558301158 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Lipid and atherosclerosis 0 -0.507905138 -0.46975547 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Lipid and atherosclerosis 0 -0.755928854 0 kegg kegg NA NA no no no no no no Dilated cardiomyopathy Lipid and atherosclerosis 0 -0.56916996 0 kegg kegg NA NA no up up no no no DNA replication Lipid and atherosclerosis 0 -0.675889328 -0.512741313 kegg kegg NA NA no no no no no no Dopaminergic synapse Lipid and atherosclerosis 0 -0.731225296 0 kegg kegg NA NA no up no no no no Dorea Lipid and atherosclerosis 0 0 -0.408520526 Genus kegg 0.00362 NA up no dn no no no Drug metabolism - cytochrome P450 Lipid and atherosclerosis 0 -0.583992095 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Lipid and atherosclerosis 0 -0.503952569 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Lipid and atherosclerosis -0.414782609 0 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Lipid and atherosclerosis -0.411304348 -0.62944664 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Lipid and atherosclerosis -0.590434783 -0.828063241 0 kegg kegg NA NA no no no no no no Endocrine resistance Lipid and atherosclerosis -0.42 -0.561264822 0 kegg kegg NA NA no no no no no no Endocytosis Lipid and atherosclerosis 0 0.70256917 0.519176319 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Lipid and atherosclerosis 0.626956522 0.848814229 0.736679537 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Lipid and atherosclerosis 0 0 0.525353925 kegg kegg NA NA no no no no no no Estrogen signaling pathway Lipid and atherosclerosis 0 -0.513833992 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Lipid and atherosclerosis 0 -0.587944664 -0.58996139 kegg kegg NA NA no no no no no no Fanconi anemia pathway Lipid and atherosclerosis 0 -0.453557312 -0.588931789 kegg kegg NA NA no no no no no no Fat digestion and absorption Lipid and atherosclerosis 0.608695652 0.747035573 0.554954955 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Lipid and atherosclerosis 0.714782609 0.789525692 0.552123552 kegg kegg NA NA no no no no no no Fatty acid degradation Lipid and atherosclerosis 0.595652174 0.696640316 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Lipid and atherosclerosis 0.529565217 0.738142292 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Lipid and atherosclerosis 0 0.799407115 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Lipid and atherosclerosis 0.771304348 0.872529644 0.823680824 kegg kegg NA NA no no no no no no Folate biosynthesis Lipid and atherosclerosis 0 -0.522727273 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Lipid and atherosclerosis 0.480869565 0 0 kegg kegg NA NA no no no no no no GABAergic synapse Lipid and atherosclerosis 0.575652174 0.536561265 0.546460746 kegg kegg NA NA no up up no no no Galactose metabolism Lipid and atherosclerosis 0 0.600790514 0 kegg kegg NA NA no no no no no no Gap junction Lipid and atherosclerosis -0.497391304 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Lipid and atherosclerosis 0 -0.542490119 0 kegg kegg NA NA no no no no no no Gastric cancer Lipid and atherosclerosis 0 0 -0.46023166 kegg kegg NA NA no no no no no no Glucagon signaling pathway Lipid and atherosclerosis -0.493913043 -0.907114625 -0.60952381 kegg kegg NA NA no no no no no no Glutathione metabolism Lipid and atherosclerosis -0.668695652 -0.733201581 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Lipid and atherosclerosis 0 0 -0.519176319 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Lipid and atherosclerosis -0.665217391 -0.540513834 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Lipid and atherosclerosis 0.554782609 0.528656126 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Lipid and atherosclerosis 0 -0.459486166 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Lipid and atherosclerosis -0.505217391 -0.51284585 -0.459202059 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Lipid and atherosclerosis 0.414782609 0.669960474 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Lipid and atherosclerosis 0 0 -0.424195624 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Lipid and atherosclerosis 0 -0.445652174 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Lipid and atherosclerosis 0.546956522 0.808300395 0.661261261 kegg kegg NA NA no no no no no no GnRH signaling pathway Lipid and atherosclerosis -0.48 -0.661067194 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Lipid and atherosclerosis 0 0.585968379 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Lipid and atherosclerosis 0 -0.531620553 -0.626512227 kegg kegg NA NA no no no no no no Hepatitis B Lipid and atherosclerosis 0.562608696 0.677865613 0 kegg kegg NA NA no no no no no no Hepatitis C Lipid and atherosclerosis 0 0.415019763 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Lipid and atherosclerosis 0 -0.479249012 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Lipid and atherosclerosis 0 0 0.421621622 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Lipid and atherosclerosis 0 -0.501976285 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Lipid and atherosclerosis 0 -0.506916996 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Lipid and atherosclerosis 0.619130435 0.684782609 0 kegg kegg NA NA no no no no no no Homologous recombination Lipid and atherosclerosis 0 0 -0.617503218 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Lipid and atherosclerosis 0 0 0.600514801 kegg kegg NA NA no no dn no no no Human immunodeficiency virus 1 infection Lipid and atherosclerosis 0 0 0.577091377 kegg kegg NA NA no no no no no no Human papillomavirus infection Lipid and atherosclerosis 0 0.608695652 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Lipid and atherosclerosis 0 0 0.483655084 kegg kegg NA NA no no no no no no Huntington disease Lipid and atherosclerosis 0 -0.776679842 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Lipid and atherosclerosis 0.794782609 0.855731225 0.834749035 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Lipid and atherosclerosis -0.406086957 -0.820158103 -0.521492921 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Lipid and atherosclerosis 0 0 -0.534877735 kegg kegg NA NA no no no no no no Insulin resistance Lipid and atherosclerosis 0 0.448616601 0 kegg kegg NA NA no no no no no no Insulin secretion Lipid and atherosclerosis -0.700869565 -0.726284585 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Lipid and atherosclerosis 0 -0.638339921 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Lipid and atherosclerosis 0 0.470355731 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Lipid and atherosclerosis 0 0 0.524324324 kegg kegg NA NA no no no no no no Longevity regulating pathway Lipid and atherosclerosis -0.416521739 0 0 kegg kegg NA NA no no no no no no Lysine degradation Lipid and atherosclerosis 0 -0.442687747 -0.621879022 kegg kegg NA NA no no no no no no Lysosome Lipid and atherosclerosis 0.528695652 0.780632411 0.72046332 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Lipid and atherosclerosis 0 -0.41798419 -0.602059202 kegg kegg NA NA no no no no no no MAPK signaling pathway Lipid and atherosclerosis 0.470434783 0 0 kegg kegg NA NA no no no no no no Measles Lipid and atherosclerosis 0.46173913 0 0 kegg kegg NA NA no no no no no no Melanogenesis Lipid and atherosclerosis -0.612173913 -0.806324111 -0.492664093 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Lipid and atherosclerosis 0 -0.469367589 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Lipid and atherosclerosis 0 0.505928854 0 kegg kegg NA NA no no no no no no Mineral absorption Lipid and atherosclerosis -0.53826087 -0.472332016 0 kegg kegg NA NA no no no no no no Mismatch repair Lipid and atherosclerosis 0 -0.488142292 0 kegg kegg NA NA no no no no no no Mitophagy - animal Lipid and atherosclerosis -0.593043478 -0.602766798 0 kegg kegg NA NA no no no no no no Morphine addiction Lipid and atherosclerosis -0.473913043 -0.722332016 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Lipid and atherosclerosis 0 -0.817193676 -0.702187902 kegg kegg NA NA no no no no no no mTOR signaling pathway Lipid and atherosclerosis -0.410434783 -0.608695652 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Lipid and atherosclerosis 0 -0.78458498 -0.605405405 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Lipid and atherosclerosis 0 0.665019763 0.508365508 kegg kegg NA NA no no no no no no Necroptosis Lipid and atherosclerosis -0.433913043 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Lipid and atherosclerosis 0.593913043 0.796442688 0.824453024 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Lipid and atherosclerosis 0 0.498023715 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Lipid and atherosclerosis 0.576521739 0.802371542 0.792277992 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Lipid and atherosclerosis 0.511304348 0.635375494 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Lipid and atherosclerosis 0.746956522 0.804347826 0.749292149 kegg kegg NA NA no no no no no no Nitrogen metabolism Lipid and atherosclerosis 0.537391304 0.688735178 0.540540541 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Lipid and atherosclerosis 0.837391304 0.840909091 0.601801802 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Lipid and atherosclerosis 0 -0.717391304 -0.422651223 kegg kegg NA NA no no no no no no Nucleotide excision repair Lipid and atherosclerosis 0 -0.613636364 -0.614414414 kegg kegg NA NA no no no no no no Olfactory transduction Lipid and atherosclerosis 0.759130435 0.798418972 0.798455598 kegg kegg NA NA no no no no no no One carbon pool by folate Lipid and atherosclerosis 0 -0.67687747 -0.676190476 kegg kegg NA NA no no no no no no Oocyte meiosis Lipid and atherosclerosis 0 0 -0.428571429 kegg kegg NA NA no no no no no no Osteoclast differentiation Lipid and atherosclerosis 0.73826087 0.911067194 0.831145431 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Lipid and atherosclerosis 0 -0.492094862 -0.672586873 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Lipid and atherosclerosis -0.533043478 -0.454545455 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Lipid and atherosclerosis 0 -0.743083004 0 kegg kegg NA NA no no no no no no p53 signaling pathway Lipid and atherosclerosis 0 0 -0.603603604 kegg kegg NA NA no no no no no no Pancreatic secretion Lipid and atherosclerosis -0.435652174 -0.730237154 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Lipid and atherosclerosis 0.817391304 0.843873518 0.61029601 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Lipid and atherosclerosis 0 -0.624505929 0 kegg kegg NA NA no no no no no no Parkinson disease Lipid and atherosclerosis -0.482608696 -0.706521739 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Lipid and atherosclerosis 0.55826087 0.747035573 0.645045045 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Lipid and atherosclerosis -0.49826087 -0.716403162 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis 0 0.574110672 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Lipid and atherosclerosis 0 -0.602766798 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Lipid and atherosclerosis 0 0.830039526 0.75984556 kegg kegg NA NA no no no no no no Peroxisome Lipid and atherosclerosis 0.633913043 0.82312253 0.574002574 kegg kegg NA NA no no no no no no Pertussis Lipid and atherosclerosis 0.773913043 0.95256917 0.844015444 kegg kegg NA NA no no dn no no no Phagosome Lipid and atherosclerosis 0 0.73715415 0.682625483 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Lipid and atherosclerosis 0 -0.449604743 -0.613384813 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Lipid and atherosclerosis 0 0.444664032 0 kegg kegg NA NA no up up no no no Platinum drug resistance Lipid and atherosclerosis 0 0 -0.516087516 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Lipid and atherosclerosis -0.629565217 -0.477272727 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Lipid and atherosclerosis 0.656521739 0.792490119 0.785328185 kegg kegg NA NA no no no no no no Prion disease Lipid and atherosclerosis 0 -0.735177866 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Lipid and atherosclerosis 0.41826087 0.641304348 0 kegg kegg NA NA no no no no no no Propanoate metabolism Lipid and atherosclerosis 0 -0.446640316 0 kegg kegg NA NA no no no no no no Prostate cancer Lipid and atherosclerosis 0 0.423913043 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Lipid and atherosclerosis 0 0.726284585 0 yes kegg kegg NA NA no up up no no no Protein export Lipid and atherosclerosis 0 -0.64229249 -0.43989704 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Lipid and atherosclerosis -0.517391304 -0.792490119 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Lipid and atherosclerosis 0 -0.651185771 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Lipid and atherosclerosis 0 -0.685770751 0 kegg kegg NA NA no no no no no no Purine metabolism Lipid and atherosclerosis -0.593913043 -0.591897233 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Lipid and atherosclerosis 0 -0.595849802 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Lipid and atherosclerosis 0 -0.602766798 0 kegg kegg NA NA no no no no no no Ras signaling pathway Lipid and atherosclerosis 0 -0.627470356 -0.506821107 yes kegg kegg NA NA no up up no no no Regulation of lipolysis in adipocytes Lipid and atherosclerosis 0 -0.553359684 0 kegg kegg NA NA no no no no no no Renin secretion Lipid and atherosclerosis -0.515652174 -0.722332016 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Lipid and atherosclerosis 0.626086957 0.849802372 0.615701416 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Lipid and atherosclerosis 0 -0.708498024 0 kegg kegg NA NA no no up no no no Rheumatoid arthritis Lipid and atherosclerosis 0 0.830039526 0.470785071 kegg kegg NA NA no no no no no no Ribosome Lipid and atherosclerosis -0.554782609 -0.684782609 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Lipid and atherosclerosis 0 -0.678853755 -0.681338481 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Lipid and atherosclerosis 0.519130435 0.633399209 0 kegg kegg NA NA no no no no no no RNA degradation Lipid and atherosclerosis 0 -0.824110672 -0.597425997 kegg kegg NA NA no no no no no no RNA polymerase Lipid and atherosclerosis 0 -0.795454545 -0.646846847 kegg kegg NA NA no no no no no no RNA transport Lipid and atherosclerosis 0 -0.497035573 0 kegg kegg NA NA no no no no no no Salmonella infection Lipid and atherosclerosis 0.635652174 0.709486166 0.542599743 kegg kegg NA NA no no no no no no Selenocompound metabolism Lipid and atherosclerosis 0 0 -0.545688546 kegg kegg NA NA no no no no no no Shigellosis Lipid and atherosclerosis -0.500869565 -0.463438735 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Lipid and atherosclerosis 0 0 -0.502187902 kegg kegg NA NA no no no no no no Small cell lung cancer Lipid and atherosclerosis 0 0.419960474 0 kegg kegg NA NA no no up no no no SNARE interactions in vesicular transport Lipid and atherosclerosis 0 0.445652174 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Lipid and atherosclerosis 0 0.515810277 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Lipid and atherosclerosis 0 -0.638339921 0 kegg kegg NA NA no no no no no no Spliceosome Lipid and atherosclerosis 0 0 -0.541827542 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Lipid and atherosclerosis 0 0.766798419 0.727927928 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Lipid and atherosclerosis 0.587826087 0.805335968 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Lipid and atherosclerosis 0 0 -0.407464607 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Lipid and atherosclerosis 0.605217391 0.82312253 0.563963964 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Lipid and atherosclerosis 0 -0.481225296 -0.413384813 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Lipid and atherosclerosis 0 0.750988142 0.600772201 kegg kegg NA NA no no no no no no Taste transduction Lipid and atherosclerosis 0 -0.505928854 -0.594337194 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Lipid and atherosclerosis 0 0 -0.454054054 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Lipid and atherosclerosis 0 -0.552371542 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Lipid and atherosclerosis 0 0.433794466 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Lipid and atherosclerosis 0 0.466403162 0 kegg kegg NA NA no no no no no no Thermogenesis Lipid and atherosclerosis 0 -0.789525692 0 kegg kegg NA NA no no no no no no Thiamine metabolism Lipid and atherosclerosis 0 -0.479249012 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Lipid and atherosclerosis 0 -0.551383399 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Lipid and atherosclerosis -0.792173913 -0.688735178 0 kegg kegg NA NA no no no no no no TNF signaling pathway Lipid and atherosclerosis 0 0.544466403 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Lipid and atherosclerosis 0.526956522 0.783596838 0.651480051 yes kegg kegg NA NA no no no no no no Toxoplasmosis Lipid and atherosclerosis 0 0.695652174 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Lipid and atherosclerosis 0.493913043 0.57312253 0 kegg kegg NA NA no no no no no no Tuberculosis Lipid and atherosclerosis 0.460869565 0.858695652 0.714800515 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Lipid and atherosclerosis 0 0.587944664 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Lipid and atherosclerosis 0 -0.498023715 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Lipid and atherosclerosis 0 0 -0.566280566 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Lipid and atherosclerosis -0.676521739 -0.70256917 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Lipid and atherosclerosis 0 -0.444664032 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Lipid and atherosclerosis 0 -0.624505929 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Lipid and atherosclerosis -0.450434783 -0.600790514 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Lipid and atherosclerosis -0.531304348 -0.788537549 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Lipid and atherosclerosis 0 0.672924901 0.40952381 kegg kegg NA NA no no no no no no Viral myocarditis Lipid and atherosclerosis 0 0.448616601 0.401029601 kegg kegg NA NA no no no no no no Wnt signaling pathway Lipid and atherosclerosis 0 -0.856719368 -0.577863578 kegg kegg NA NA no no no no no no Yersinia infection Lipid and atherosclerosis 0.608695652 0.744071146 0.503217503 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Long-term depression -0.482608696 0 -0.571428571 kegg kegg NA NA no no no no no no ABC transporters Long-term depression -0.726086957 0 0 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes Long-term depression 0.766086957 0.470355731 0.537451737 kegg kegg NA NA no no up no no no alpha-Linolenic acid metabolism Long-term depression -0.660869565 0 -0.647104247 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Long-term depression -0.645217391 0 -0.540540541 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Long-term depression -0.670434783 -0.5 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Long-term depression 0 0 0.446074646 kegg kegg NA NA no no no no no no Arginine and proline metabolism Long-term depression -0.44173913 0 0 kegg kegg NA NA no up no no no no Ascorbate and aldarate metabolism Long-term depression 0 0 -0.763706564 kegg kegg NA NA no no no no no no Bacteroides Long-term depression 0 -0.491106719 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Long-term depression 0 0 -0.406949807 kegg kegg NA NA no no no no no no Base excision repair Long-term depression -0.482608696 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Long-term depression -0.557391304 -0.59486166 -0.523809524 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Long-term depression -0.457391304 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Long-term depression 0 0 0.445045045 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Long-term depression -0.515652174 -0.588932806 0 kegg kegg NA NA no no no no no no Butanoate metabolism Long-term depression -0.57826087 -0.52173913 -0.500643501 kegg kegg NA NA no no no no no no Butyricimonas Long-term depression 0.47822921 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no Calcium signaling pathway Long-term depression 0.74173913 0.635375494 0.566795367 kegg kegg NA NA no up up no no no cAMP signaling pathway Long-term depression 0.597391304 0.719367589 0.675933076 yes kegg kegg NA NA no up up no no no Carbon metabolism Long-term depression -0.505217391 -0.577075099 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Long-term depression 0.587826087 0 0 kegg kegg NA NA no no up no no no Circadian entrainment Long-term depression 0.59826087 0 0.720978121 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Long-term depression -0.543478261 -0.597826087 -0.70965251 kegg kegg NA NA no no no no no no Clostridium Long-term depression 0 -0.530797652 0 Genus kegg 0.925 NA no no no no no no Cysteine and methionine metabolism Long-term depression -0.413913043 -0.528656126 0 kegg kegg NA NA no no no no no no DNA replication Long-term depression -0.51826087 0 -0.497554698 kegg kegg NA NA no no no no no no Dopaminergic synapse Long-term depression 0.67826087 0 0.603861004 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Long-term depression 0 0 -0.407722008 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Long-term depression -0.54 0 -0.624195624 kegg kegg NA NA no no no no no no Endocrine resistance Long-term depression 0.749565217 0.587944664 0.803346203 kegg kegg NA NA no no no no no no Ether lipid metabolism Long-term depression 0 0 -0.483655084 kegg kegg NA NA no no no no no no Fanconi anemia pathway Long-term depression -0.513913043 0 -0.454054054 kegg kegg NA NA no no no no no no Fatty acid degradation Long-term depression -0.659130435 0 -0.602316602 kegg kegg NA NA no no no no no no Fatty acid elongation Long-term depression -0.434782609 -0.593873518 -0.41981982 kegg kegg NA NA no no no no no no Fatty acid metabolism Long-term depression -0.664347826 -0.419960474 -0.47953668 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Long-term depression -0.446086957 0 0 kegg kegg NA NA no no no no no no Ferroptosis Long-term depression 0.575652174 0.652173913 0 kegg kegg NA NA no no no no no no Folate biosynthesis Long-term depression -0.450434783 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Long-term depression -0.604347826 0 -0.514800515 kegg kegg NA NA no no no no no no Galactose metabolism Long-term depression -0.591304348 0 -0.61956242 kegg kegg NA NA no no no no no no Gap junction Long-term depression 0.735652174 0.882411067 0.832947233 kegg kegg NA NA no no no no no no Glutamatergic synapse Long-term depression 0.750434783 0.668972332 0.779407979 kegg kegg NA NA no up up no no no Glycerolipid metabolism Long-term depression -0.445217391 0 -0.483912484 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Long-term depression 0 0 -0.487516088 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Long-term depression 0 0 0.488030888 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Long-term depression -0.52 -0.504940711 -0.417245817 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Long-term depression 0 0 -0.57992278 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Long-term depression 0.624347826 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Long-term depression 0 0 -0.605662806 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Long-term depression -0.51826087 0 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Long-term depression 0 -0.652173913 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Long-term depression 0 0 -0.420849421 kegg kegg NA NA no no no no no no Histidine metabolism Long-term depression -0.53826087 -0.501976285 -0.625740026 kegg kegg NA NA no no no no no no Homologous recombination Long-term depression -0.526086957 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Long-term depression -0.455652174 0 -0.451222651 kegg kegg NA NA no no no no no no Long-term potentiation Long-term depression 0 -0.574110672 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Long-term depression 0.504347826 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Long-term depression 0 -0.754940711 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Long-term depression 0 -0.548418972 -0.416988417 kegg kegg NA NA no no no no no no Mismatch repair Long-term depression -0.580869565 -0.537549407 0 kegg kegg NA NA no no no no no no Mitophagy - animal Long-term depression 0.589565217 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Long-term depression -0.479130435 -0.535573123 0 kegg kegg NA NA no no no no no no Necroptosis Long-term depression 0.634782609 0.595849802 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Long-term depression -0.47826087 0 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Long-term depression -0.413913043 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Long-term depression -0.508695652 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Long-term depression -0.568695652 -0.718379447 0 kegg kegg NA NA no no no no no no Notch signaling pathway Long-term depression 0 0 -0.44993565 kegg kegg NA NA no no no no no no Nucleotide excision repair Long-term depression -0.526956522 -0.425889328 0 kegg kegg NA NA no no no no no no Odoribacter Long-term depression -0.436302232 -0.504706847 0 butyrate-producing Genus kegg 0.798 NA no no no no no no One carbon pool by folate Long-term depression 0 0 -0.419047619 kegg kegg NA NA no no no no no no Oocyte meiosis Long-term depression 0 -0.551383399 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Long-term depression -0.428695652 0 0 kegg kegg NA NA no no no no no no Other glycan degradation Long-term depression -0.609565217 0 -0.496267696 kegg kegg NA NA no no no no no no Oxidative phosphorylation Long-term depression 0.536521739 0 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Long-term depression 0 0 -0.415186615 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Long-term depression 0 0 -0.457657658 kegg kegg NA NA no no no no no no Peroxisome Long-term depression -0.635652174 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Long-term depression 0 -0.463438735 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Long-term depression 0.543478261 0.531620553 0.573487773 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Long-term depression -0.457391304 0 0 yes kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism Long-term depression 0 0 0.445559846 kegg kegg NA NA no no no no no no Prevotella Long-term depression 0 0 0.462551243 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Long-term depression -0.611304348 -0.713438735 0 kegg kegg NA NA no no no no no no Propanoate metabolism Long-term depression -0.546086957 -0.54743083 0 kegg kegg NA NA no no no no no no Proteasome Long-term depression 0 -0.542490119 -0.624710425 kegg kegg NA NA no no no no no no Pyrimidine metabolism Long-term depression -0.635652174 0 -0.417245817 kegg kegg NA NA no no no no no no Pyruvate metabolism Long-term depression -0.540869565 -0.425889328 0 kegg kegg NA NA no no no no no no Retinol metabolism Long-term depression -0.570434783 -0.41798419 -0.697812098 kegg kegg NA NA no no no no no no RNA polymerase Long-term depression 0 0 -0.46975547 kegg kegg NA NA no no no no no no RNA transport Long-term depression -0.526956522 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Long-term depression 0 0 -0.555984556 kegg kegg NA NA no no no no no no Serotonergic synapse Long-term depression 0.456521739 0.60770751 0.732561133 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Long-term depression -0.623478261 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Long-term depression 0 0 -0.525611326 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Long-term depression -0.507826087 0 -0.53951094 kegg kegg NA NA no no no no no no Steroid biosynthesis Long-term depression 0 -0.570158103 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Long-term depression -0.448695652 -0.475296443 -0.697554698 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Long-term depression 0 0 -0.419047619 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Long-term depression -0.463478261 -0.580039526 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Long-term depression 0 -0.550395257 -0.488545689 kegg kegg NA NA no no no no no no Thermogenesis Long-term depression 0.585217391 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Long-term depression -0.529565217 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Long-term depression -0.622608696 -0.672924901 -0.658429858 kegg kegg NA NA no up no no no no Ubiquinone and other terpenoid-quinone biosynthesis Long-term depression -0.613913043 -0.532608696 -0.441698842 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Long-term depression 0.571304348 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Long-term depression -0.647826087 -0.519762846 -0.561389961 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Long-term depression 0.713043478 0 0.554440154 kegg kegg NA NA no no no no no no Wnt signaling pathway Long-term depression 0.493043478 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Long-term potentiation -0.489565217 0 0 kegg kegg NA NA no no no no no up ABC transporters Long-term potentiation -0.407826087 0 0 kegg kegg NA NA no up up no no up Adherens junction Long-term potentiation -0.415652174 0 0 kegg kegg NA NA no no no no no up Adrenergic signaling in cardiomyocytes Long-term potentiation 0.623478261 0 0.541312741 kegg kegg NA NA no no up no no up "Alanine, aspartate and glutamate metabolism" Long-term potentiation 0 -0.431818182 -0.458944659 kegg kegg NA NA no no no no no up alpha-Linolenic acid metabolism Long-term potentiation -0.587826087 0 0 kegg kegg NA NA no no no no no up AMPK signaling pathway Long-term potentiation 0 0 -0.465379665 kegg kegg NA NA no no no no no up Apelin signaling pathway Long-term potentiation 0.45826087 0.688735178 0 kegg kegg NA NA no no no no no up Apoptosis Long-term potentiation -0.563478261 -0.648221344 -0.420849421 kegg kegg NA NA no no no no no up Arachidonic acid metabolism Long-term potentiation 0 0 -0.536936937 kegg kegg NA NA no no no no no up Arginine biosynthesis Long-term potentiation 0 -0.432806324 -0.518661519 kegg kegg NA NA no no no no no up Autophagy - animal Long-term potentiation 0 -0.454545455 0 kegg kegg NA NA no no no no no up Autophagy - other Long-term potentiation 0.570434783 0 0.695752896 kegg kegg NA NA no no no no no up Axon guidance Long-term potentiation 0.557391304 0 0.57014157 kegg kegg NA NA no up up no no up B cell receptor signaling pathway Long-term potentiation 0 -0.56027668 0 kegg kegg NA NA no no no no no up Bacteroides Long-term potentiation 0 0.588932806 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no up Basal transcription factors Long-term potentiation 0.514782609 0.511857708 0.552895753 kegg kegg NA NA no no no no no up beta-Alanine metabolism Long-term potentiation -0.576521739 0.514822134 0 kegg kegg NA NA no no no no no up Biosynthesis of amino acids Long-term potentiation -0.53826087 0 -0.563706564 kegg kegg NA NA no no no no no up Biosynthesis of cofactors Long-term potentiation 0 0.479249012 -0.510939511 kegg kegg NA NA no no no no no up Biosynthesis of unsaturated fatty acids Long-term potentiation 0 0.57312253 0 kegg kegg NA NA no no no no no up Butanoate metabolism Long-term potentiation -0.42 0.706521739 0 kegg kegg NA NA no no no no no up C-type lectin receptor signaling pathway Long-term potentiation 0 -0.520750988 0 kegg kegg NA NA no no no no no up Calcium signaling pathway Long-term potentiation 0.553043478 0 0.447876448 kegg kegg NA NA no up up no no up cAMP signaling pathway Long-term potentiation 0.554782609 -0.602766798 0 yes kegg kegg NA NA no up up no no up Carbon metabolism Long-term potentiation -0.494782609 0 -0.425740026 kegg kegg NA NA no no no no no up Cell adhesion molecules Long-term potentiation -0.45826087 0 0 kegg kegg NA NA no no no no no up Cell cycle Long-term potentiation 0.62 0.459486166 0.675418275 kegg kegg NA NA no no no no no up Cellular senescence Long-term potentiation 0 -0.539525692 0 kegg kegg NA NA no no no no no up Chemokine signaling pathway Long-term potentiation 0 -0.505928854 0 kegg kegg NA NA no no no no no up Circadian rhythm Long-term potentiation 0.700869565 0 0.737451737 kegg kegg NA NA no no no no no up Citrate cycle (TCA cycle) Long-term potentiation 0 0.743083004 0 kegg kegg NA NA no no no no no up Clostridium Long-term potentiation 0 0.524684819 0 Genus kegg 0.925 NA no no no no no up Collinsella Long-term potentiation 0 0 -0.40004125 Genus kegg 0.128 NA no no no no no up Complement and coagulation cascades Long-term potentiation -0.465217391 0 -0.427284427 kegg kegg NA NA no no no no no up Cysteine and methionine metabolism Long-term potentiation 0 0.817193676 0 kegg kegg NA NA no no no no no up DNA replication Long-term potentiation 0 0.621541502 0 kegg kegg NA NA no no no no no up Drug metabolism - cytochrome P450 Long-term potentiation 0 0.601778656 0 kegg kegg NA NA no no no no no up Drug metabolism - other enzymes Long-term potentiation 0 0.604743083 0 kegg kegg NA NA no no no no no up ECM-receptor interaction Long-term potentiation 0 0.551383399 0.427541828 kegg kegg NA NA no up up no no up EGFR tyrosine kinase inhibitor resistance Long-term potentiation 0 0.593873518 0 kegg kegg NA NA no no no no no up ErbB signaling pathway Long-term potentiation 0 -0.415019763 0.568339768 kegg kegg NA NA no no no no no up Fanconi anemia pathway Long-term potentiation 0 0 0.436550837 kegg kegg NA NA no no no no no up Fatty acid biosynthesis Long-term potentiation 0 -0.460474308 0 kegg kegg NA NA no no no no no up Fatty acid elongation Long-term potentiation 0 0.605731225 0 kegg kegg NA NA no no no no no up Fc epsilon RI signaling pathway Long-term potentiation 0 -0.605731225 0 kegg kegg NA NA no no no no no up Ferroptosis Long-term potentiation 0 -0.483201581 -0.481853282 kegg kegg NA NA no no no no no up Fructose and mannose metabolism Long-term potentiation -0.671304348 -0.567193676 -0.472844273 kegg kegg NA NA no no no no no up Galactose metabolism Long-term potentiation -0.68 0 0 kegg kegg NA NA no no no no no up Gap junction Long-term potentiation 0 -0.53458498 0 kegg kegg NA NA no no no no no up Glutathione metabolism Long-term potentiation 0 0 -0.506821107 kegg kegg NA NA no no no no no up Glycerolipid metabolism Long-term potentiation 0 -0.470355731 0 kegg kegg NA NA no no up no no up Glycerophospholipid metabolism Long-term potentiation 0 0 0.441441441 kegg kegg NA NA no no up no no up "Glycine, serine and threonine metabolism" Long-term potentiation 0 0 -0.513256113 kegg kegg NA NA no up no no no up Glycolysis / Gluconeogenesis Long-term potentiation 0 0.675889328 0 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Long-term potentiation 0 -0.7243083 0 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - keratan sulfate Long-term potentiation 0 0 0.447619048 kegg kegg NA NA no no no no no up Glycosphingolipid biosynthesis - lacto and neolacto series Long-term potentiation 0 -0.596837945 0 kegg kegg NA NA no no no no no up Glyoxylate and dicarboxylate metabolism Long-term potentiation 0 0 -0.52972973 kegg kegg NA NA no no no no no up Hedgehog signaling pathway Long-term potentiation 0.45826087 0 0.56010296 kegg kegg NA NA no no no no no up Hematopoietic cell lineage Long-term potentiation 0 0.540513834 0 kegg kegg NA NA no no no no no up HIF-1 signaling pathway Long-term potentiation 0 0.611660079 0 kegg kegg NA NA no no no no no up JAK-STAT signaling pathway Long-term potentiation 0 -0.548418972 0 kegg kegg NA NA no no no no no up Longevity regulating pathway - multiple species Long-term potentiation 0 0.473320158 0 kegg kegg NA NA no no no no no up Lysine degradation Long-term potentiation 0 0 0.567567568 kegg kegg NA NA no no no no no up Mannose type O-glycan biosynthesis Long-term potentiation 0 0 0.595109395 kegg kegg NA NA no no no no no up MAPK signaling pathway Long-term potentiation 0 0 0.433462033 kegg kegg NA NA no no no no no up Metabolism of xenobiotics by cytochrome P450 Long-term potentiation 0 0.615612648 0 kegg kegg NA NA no no no no no up Mismatch repair Long-term potentiation 0 0.743083004 0 kegg kegg NA NA no no no no no up mRNA surveillance pathway Long-term potentiation 0.506086957 0 0.680823681 kegg kegg NA NA no no no no no up mTOR signaling pathway Long-term potentiation 0 0.617588933 0 kegg kegg NA NA no no no no no up N-Glycan biosynthesis Long-term potentiation 0.494782609 0.499011858 0.41003861 kegg kegg NA NA no no no no no up Natural killer cell mediated cytotoxicity Long-term potentiation 0 -0.41798419 0 kegg kegg NA NA no no no no no up Necroptosis Long-term potentiation 0 0 -0.454568855 kegg kegg NA NA no no no no no up Neutrophil extracellular trap formation Long-term potentiation -0.44173913 0 -0.480823681 kegg kegg NA NA no no no no no up NF-kappa B signaling pathway Long-term potentiation 0 -0.628458498 0 kegg kegg NA NA no no no no no up Nicotinate and nicotinamide metabolism Long-term potentiation 0 -0.535573123 0 kegg kegg NA NA no no no no no up Non-homologous end-joining Long-term potentiation 0 0.761857708 0 kegg kegg NA NA no no no no no up Notch signaling pathway Long-term potentiation 0 -0.483201581 0.473873874 kegg kegg NA NA no no no no no up Nucleotide excision repair Long-term potentiation 0 0.64229249 0 kegg kegg NA NA no no no no no up One carbon pool by folate Long-term potentiation 0 0.489130435 0 kegg kegg NA NA no no no no no up Oocyte meiosis Long-term potentiation 0.809565217 0.904150198 0.791505792 kegg kegg NA NA no no no no no up Other types of O-glycan biosynthesis Long-term potentiation 0 0 0.534362934 kegg kegg NA NA no no no no no up p53 signaling pathway Long-term potentiation 0.439130435 0 0 kegg kegg NA NA no no no no no up Pentose and glucuronate interconversions Long-term potentiation 0 0.68972332 0 kegg kegg NA NA no no no no no up Pentose phosphate pathway Long-term potentiation -0.614782609 0 -0.561132561 kegg kegg NA NA no no no no no up Peroxisome Long-term potentiation 0 0 -0.542084942 kegg kegg NA NA no no no no no up Phagosome Long-term potentiation -0.542608696 0 0 kegg kegg NA NA no no no no no up Phenylalanine metabolism Long-term potentiation -0.46173913 0.501976285 0 kegg kegg NA NA no no no no no up Phosphatidylinositol signaling system Long-term potentiation 0.711304348 0 0.656628057 kegg kegg NA NA no no no no no up Phospholipase D signaling pathway Long-term potentiation 0 -0.813241107 0 kegg kegg NA NA no up up no no up PI3K-Akt signaling pathway Long-term potentiation 0 0 0.407207207 yes kegg kegg NA NA no up up no no up Platinum drug resistance Long-term potentiation 0.435652174 0 0 kegg kegg NA NA no no no no no up Porphyrin and chlorophyll metabolism Long-term potentiation 0 0 -0.530759331 kegg kegg NA NA no no no no no up Primary bile acid biosynthesis Long-term potentiation 0 0.748023715 0 kegg kegg NA NA no no no no no up Propanoate metabolism Long-term potentiation 0 0.798418972 0 kegg kegg NA NA no no no no no up Proteasome Long-term potentiation 0 0.664031621 0 kegg kegg NA NA no no no no no up Protein export Long-term potentiation 0.659130435 0.65513834 0.623938224 kegg kegg NA NA no no no no no up Protein processing in endoplasmic reticulum Long-term potentiation 0 0.528656126 0 kegg kegg NA NA no no no no no up Purine metabolism Long-term potentiation 0 0 -0.454826255 kegg kegg NA NA no no no no no up Pyrimidine metabolism Long-term potentiation 0 0.463438735 0 kegg kegg NA NA no no no no no up Pyruvate metabolism Long-term potentiation 0 0.7756917 0 kegg kegg NA NA no no no no no up Ras signaling pathway Long-term potentiation 0.642608696 0.568181818 0.761904762 yes kegg kegg NA NA no up up no no up Retinol metabolism Long-term potentiation 0 0.434782609 0 kegg kegg NA NA no no no no no up Ribosome Long-term potentiation 0.415652174 0.51284585 0 kegg kegg NA NA no no no no no up Ribosome biogenesis in eukaryotes Long-term potentiation 0.417391304 0.462450593 0.543114543 kegg kegg NA NA no no no no no up RIG-I-like receptor signaling pathway Long-term potentiation 0 -0.556324111 0 kegg kegg NA NA no no no no no up RNA degradation Long-term potentiation 0.504347826 0.472332016 0.722779923 kegg kegg NA NA no no no no no up RNA polymerase Long-term potentiation 0.495652174 0.517786561 0 kegg kegg NA NA no no no no no up RNA transport Long-term potentiation 0 0.668972332 0 kegg kegg NA NA no no no no no up Signaling pathways regulating pluripotency of stem cells Long-term potentiation 0.553043478 0 0.551093951 kegg kegg NA NA no no no no no up Sphingolipid signaling pathway Long-term potentiation 0.552173913 0 0.448906049 kegg kegg NA NA no no no no no up Spliceosome Long-term potentiation 0.406956522 0 0.688803089 kegg kegg NA NA no no no no no up Starch and sucrose metabolism Long-term potentiation -0.490434783 0 0 kegg kegg NA NA no no no no no up Steroid biosynthesis Long-term potentiation 0.460869565 0.678853755 0 kegg kegg NA NA no no no no no up Steroid hormone biosynthesis Long-term potentiation 0 0.593873518 0 kegg kegg NA NA no no no no no up Sulfur metabolism Long-term potentiation -0.406086957 0 -0.564736165 kegg kegg NA NA no no no no no up Synthesis and degradation of ketone bodies Long-term potentiation 0 0.674901186 0 kegg kegg NA NA no no no no no up T cell receptor signaling pathway Long-term potentiation 0 0 0.54002574 kegg kegg NA NA no no no no no up Taurine and hypotaurine metabolism Long-term potentiation 0 -0.5 0 kegg kegg NA NA no no no no no up Terpenoid backbone biosynthesis Long-term potentiation 0.443478261 0.539525692 0.44993565 kegg kegg NA NA no no no no no up TGF-beta signaling pathway Long-term potentiation 0.548695652 0.72826087 0.727670528 kegg kegg NA NA no no no no no up Thermogenesis Long-term potentiation 0 0.425889328 0 kegg kegg NA NA no no no no no up Thiamine metabolism Long-term potentiation 0 0.765810277 0 kegg kegg NA NA no no no no no up Tight junction Long-term potentiation -0.468695652 0 0 kegg kegg NA NA no no no no no up TNF signaling pathway Long-term potentiation 0 -0.633399209 0 kegg kegg NA NA no no no no no up Toll-like receptor signaling pathway Long-term potentiation 0 -0.602766798 0 yes kegg kegg NA NA no no no no no up Tryptophan metabolism Long-term potentiation 0 0.668972332 0 kegg kegg NA NA no up no no no up Tyrosine metabolism Long-term potentiation 0 0.636363636 0 kegg kegg NA NA no no no no no up Ubiquinone and other terpenoid-quinone biosynthesis Long-term potentiation 0 0.545454545 0 kegg kegg NA NA no no no no no up "Valine, leucine and isoleucine degradation" Long-term potentiation 0 0.62055336 0 kegg kegg NA NA no no no no no up Various types of N-glycan biosynthesis Long-term potentiation 0.588695652 0.479249012 0.465122265 kegg kegg NA NA no no no no no up Vascular smooth muscle contraction Long-term potentiation 0.422608696 0 0 kegg kegg NA NA no no no no no up VEGF signaling pathway Long-term potentiation 0.419130435 -0.494071146 0.621879022 kegg kegg NA NA no no no no no up Wnt signaling pathway Long-term potentiation 0 0.428853755 0.731788932 kegg kegg NA NA no no no no no up 2-Oxocarboxylic acid metabolism Longevity regulating pathway 0 0 -0.560875161 kegg kegg NA NA no no no no no no ABC transporters Longevity regulating pathway 0 0.473320158 0 kegg kegg NA NA no up up no no no Akkermansia Longevity regulating pathway 0 -0.420779509 0 acetate-producing Genus kegg 0.23 NA no no no no no no alpha-Linolenic acid metabolism Longevity regulating pathway -0.43826087 0 -0.547232947 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Longevity regulating pathway -0.483478261 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Longevity regulating pathway 0.660869565 0.68083004 0.948519949 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Longevity regulating pathway -0.591304348 -0.449604743 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Longevity regulating pathway -0.450434783 -0.68083004 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Longevity regulating pathway 0 0.421936759 0.730759331 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Longevity regulating pathway -0.620869565 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Longevity regulating pathway 0.503478261 0 0 kegg kegg NA NA no up up no no no Carbon metabolism Longevity regulating pathway -0.466086957 -0.703557312 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Longevity regulating pathway 0 0 -0.448906049 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Longevity regulating pathway -0.555652174 0 -0.499099099 kegg kegg NA NA no no no no no no Clostridium Longevity regulating pathway 0 -0.593963591 0 Genus kegg 0.925 NA no no no no no no Cysteine and methionine metabolism Longevity regulating pathway -0.429565217 0 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Longevity regulating pathway -0.579130435 0 -0.470527671 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Longevity regulating pathway -0.508695652 0 -0.475160875 kegg kegg NA NA no no no no no no Endocrine resistance Longevity regulating pathway 0.580869565 0.445652174 0.453796654 kegg kegg NA NA no no no no no no Endocytosis Longevity regulating pathway 0 -0.420948617 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Longevity regulating pathway 0.491304348 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Longevity regulating pathway -0.669565217 -0.611660079 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Longevity regulating pathway -0.47826087 0 0 kegg kegg NA NA no no no no no no Folate biosynthesis Longevity regulating pathway -0.415652174 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Longevity regulating pathway -0.44 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Longevity regulating pathway 0 0 0.623938224 kegg kegg NA NA no no no no no no Glycerolipid metabolism Longevity regulating pathway 0 0 -0.435521236 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Longevity regulating pathway 0 0.528656126 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Longevity regulating pathway 0 0.543478261 0.785585586 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Longevity regulating pathway -0.482608696 -0.574110672 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Longevity regulating pathway 0 0 -0.436550837 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Longevity regulating pathway 0 0 -0.56962677 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Longevity regulating pathway 0.571304348 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Longevity regulating pathway 0 0 -0.660746461 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - globo and isoglobo series Longevity regulating pathway 0 0 0.421364221 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Longevity regulating pathway 0.406086957 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Longevity regulating pathway 0 0.610671937 0 kegg kegg NA NA no no no no no no Histidine metabolism Longevity regulating pathway -0.523478261 -0.415019763 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Longevity regulating pathway 0.49826087 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Longevity regulating pathway -0.594782609 -0.514822134 -0.473873874 kegg kegg NA NA no no no no no no Mismatch repair Longevity regulating pathway -0.539130435 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Longevity regulating pathway 0.582608696 0 0.701415701 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Longevity regulating pathway -0.502608696 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Longevity regulating pathway -0.605217391 0 0 kegg kegg NA NA up up up no no no Nitrogen metabolism Longevity regulating pathway 0 0 0.407207207 kegg kegg NA NA no no no no no no Non-homologous end-joining Longevity regulating pathway -0.545217391 -0.540513834 0 kegg kegg NA NA no no no no no no Other glycan degradation Longevity regulating pathway 0 0 -0.585070785 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Longevity regulating pathway 0 0.459486166 0 kegg kegg NA NA no no no no no no p53 signaling pathway Longevity regulating pathway 0.432173913 0.699604743 0 kegg kegg NA NA no no no no no no Paraprevotella Longevity regulating pathway -0.556317234 0 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Longevity regulating pathway -0.685217391 0 -0.532303732 kegg kegg NA NA no no no no no no Phagosome Longevity regulating pathway 0 -0.499011858 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Longevity regulating pathway -0.452173913 -0.553359684 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Longevity regulating pathway 0.430434783 0 0 kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism Longevity regulating pathway 0 0.568181818 0.784555985 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Longevity regulating pathway -0.569565217 -0.454545455 0 kegg kegg NA NA no no no no no no Propanoate metabolism Longevity regulating pathway -0.476521739 0 0 kegg kegg NA NA no no no no no no Proteasome Longevity regulating pathway 0 0 -0.4002574 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Longevity regulating pathway 0 0 0.471299871 kegg kegg NA NA no no no no no no Purine metabolism Longevity regulating pathway 0.531304348 0.565217391 0.709137709 kegg kegg NA NA no no no no no no Pyruvate metabolism Longevity regulating pathway -0.41826087 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Longevity regulating pathway 0 -0.43972332 0 kegg kegg NA NA no no no no no no Retinol metabolism Longevity regulating pathway -0.602608696 0 -0.442728443 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Longevity regulating pathway 0 0 -0.498069498 kegg kegg NA NA no no no no no no Sphingolipid metabolism Longevity regulating pathway 0 0 -0.445045045 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Longevity regulating pathway 0 0 -0.48005148 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Longevity regulating pathway -0.447826087 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Longevity regulating pathway -0.586086957 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Longevity regulating pathway 0 0 0.598970399 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Longevity regulating pathway -0.484347826 0 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Longevity regulating pathway 0 0.463438735 0 kegg kegg NA NA no no no no no no Thiamine metabolism Longevity regulating pathway -0.419130435 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Longevity regulating pathway -0.460869565 -0.572134387 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Longevity regulating pathway -0.453913043 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Longevity regulating pathway -0.476521739 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Longevity regulating pathway 0.56173913 0 0.68983269 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Longevity regulating pathway -0.44173913 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Longevity regulating pathway - multiple species -0.431304348 0 0 kegg kegg NA NA no no no no no no Bacteroides Longevity regulating pathway - multiple species 0 0.466403162 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no beta-Alanine metabolism Longevity regulating pathway - multiple species 0 0.566205534 0.61956242 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Longevity regulating pathway - multiple species 0.523478261 0.707509881 0.636808237 kegg kegg NA NA no no no no no no Blautia Longevity regulating pathway - multiple species 0 0.583992095 0 acetate-producing Genus kegg 1.36E-05 NA up dn dn no no no Butanoate metabolism Longevity regulating pathway - multiple species 0 0.429841897 0.580694981 kegg kegg NA NA no no no no no no Calcium signaling pathway Longevity regulating pathway - multiple species 0 -0.729249012 -0.455083655 kegg kegg NA NA no up up no no no cAMP signaling pathway Longevity regulating pathway - multiple species 0 -0.585968379 -0.501415701 yes kegg kegg NA NA no up up no no no Carbon metabolism Longevity regulating pathway - multiple species 0 0.549407115 0 kegg kegg NA NA no no no no no no Cell cycle Longevity regulating pathway - multiple species 0.546086957 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Longevity regulating pathway - multiple species 0.465217391 0.442687747 0.42033462 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Longevity regulating pathway - multiple species 0.694782609 0.429841897 0.540797941 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Longevity regulating pathway - multiple species 0 0.464426877 0 kegg kegg NA NA no no no no no no DNA replication Longevity regulating pathway - multiple species 0.547826087 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Longevity regulating pathway - multiple species 0 -0.618577075 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Longevity regulating pathway - multiple species 0.525217391 0 0 kegg kegg NA NA no no no no no no Fatty acid degradation Longevity regulating pathway - multiple species 0.54 0.438735178 0.466924067 kegg kegg NA NA no no no no no no Fatty acid elongation Longevity regulating pathway - multiple species 0 0.692687747 0.673616474 kegg kegg NA NA no no no no no no Fatty acid metabolism Longevity regulating pathway - multiple species 0.447826087 0.563241107 0.497554698 kegg kegg NA NA no no no no no no FoxO signaling pathway Longevity regulating pathway - multiple species 0.596521739 0 0.515572716 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Longevity regulating pathway - multiple species 0 0 0.533590734 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Longevity regulating pathway - multiple species 0 0 -0.451737452 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Longevity regulating pathway - multiple species 0 -0.464426877 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Longevity regulating pathway - multiple species 0 0 -0.584041184 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Longevity regulating pathway - multiple species 0.406086957 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Longevity regulating pathway - multiple species 0 0.447628458 0.44993565 kegg kegg NA NA no no no no no no Homologous recombination Longevity regulating pathway - multiple species 0.554782609 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Longevity regulating pathway - multiple species -0.433043478 -0.429841897 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Longevity regulating pathway - multiple species 0.613913043 0 0 kegg kegg NA NA no no no no no no Mismatch repair Longevity regulating pathway - multiple species 0.625217391 0.454545455 0.541312741 kegg kegg NA NA no no no no no no Mitophagy - animal Longevity regulating pathway - multiple species -0.535652174 -0.494071146 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Longevity regulating pathway - multiple species 0.626086957 0 0.46048906 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Longevity regulating pathway - multiple species 0.502608696 0.461462451 0 kegg kegg NA NA up up up no no no Non-homologous end-joining Longevity regulating pathway - multiple species 0.44 0.671936759 0.726383526 kegg kegg NA NA no no no no no no Nucleotide excision repair Longevity regulating pathway - multiple species 0.582608696 0 0.477477477 kegg kegg NA NA no no no no no no Odoribacter Longevity regulating pathway - multiple species 0 0.435365377 0 butyrate-producing Genus kegg 0.798 NA no no no no no no One carbon pool by folate Longevity regulating pathway - multiple species 0.588695652 0 0 kegg kegg NA NA no no no no no no Oocyte meiosis Longevity regulating pathway - multiple species 0.415652174 0.514822134 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Longevity regulating pathway - multiple species 0.490434783 0 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Longevity regulating pathway - multiple species 0.452173913 0 0 kegg kegg NA NA no no no no no no Peroxisome Longevity regulating pathway - multiple species 0.509565217 0.434782609 0.501158301 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Longevity regulating pathway - multiple species 0 0 -0.477220077 kegg kegg NA NA no up up no no no Primary bile acid biosynthesis Longevity regulating pathway - multiple species 0.56173913 0.670948617 0.539253539 kegg kegg NA NA no no no no no no Propanoate metabolism Longevity regulating pathway - multiple species 0.692173913 0.436758893 0.558558559 kegg kegg NA NA no no no no no no Pyruvate metabolism Longevity regulating pathway - multiple species 0.672173913 0 0.602316602 kegg kegg NA NA no no no no no no Retinol metabolism Longevity regulating pathway - multiple species 0.619130435 0 0.439382239 kegg kegg NA NA no no no no no no Steroid biosynthesis Longevity regulating pathway - multiple species 0 0.498023715 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Longevity regulating pathway - multiple species 0 0.416996047 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Longevity regulating pathway - multiple species 0.670434783 0.42687747 0.488288288 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Longevity regulating pathway - multiple species 0.590434783 0.551383399 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Longevity regulating pathway - multiple species 0.426086957 0.588932806 0.575546976 kegg kegg NA NA no up no no no no Tyrosine metabolism Longevity regulating pathway - multiple species 0.456521739 0 0.692406692 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Longevity regulating pathway - multiple species 0.409565217 0.429841897 0.41003861 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Longevity regulating pathway - multiple species -0.513913043 -0.443675889 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Longevity regulating pathway - multiple species 0.459130435 0 0.594851995 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Lysine degradation 0 0 -0.563449163 kegg kegg NA NA no no no no no no Arginine biosynthesis Lysine degradation 0 0 -0.694980695 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Lysine degradation 0 0 0.542084942 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Lysine degradation 0 0 0.423680824 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Lysine degradation 0 0.418972332 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Lysine degradation 0 0 -0.430630631 kegg kegg NA NA no up no no no no Pentose and glucuronate interconversions Lysine degradation 0 0 0.457657658 kegg kegg NA NA no no no no no no Pentose phosphate pathway Lysine degradation 0 -0.686758893 -0.611840412 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Lysine degradation 0 0 0.404375804 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Lysine degradation 0 0 0.444015444 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Lysine degradation 0 0 0.452509653 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Lysosome 0 -0.433794466 0 kegg kegg NA NA no no no no no no ABC transporters Lysosome 0 -0.498023715 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" Lysosome 0.433913043 0.432806324 0.501415701 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Lysosome 0 0 0.432689833 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Lysosome -0.533913043 -0.580039526 0 kegg kegg NA NA no no no no no no Antifolate resistance Lysosome -0.486086957 -0.707509881 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Lysosome 0.522608696 0.589920949 0.582239382 kegg kegg NA NA no up no no no no Arginine biosynthesis Lysosome 0.524347826 0.482213439 0.546718147 kegg kegg NA NA no no no no no no Basal transcription factors Lysosome -0.536521739 -0.698616601 -0.525611326 kegg kegg NA NA no no no no no no Base excision repair Lysosome -0.662608696 -0.766798419 -0.518918919 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Lysosome 0 0.782608696 0.713770914 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Lysosome -0.548695652 -0.696640316 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Lysosome 0 0 -0.522265122 kegg kegg NA NA no up up no no no Carbon metabolism Lysosome 0 0.621541502 0.696010296 kegg kegg NA NA no no no no no no Cell cycle Lysosome -0.644347826 -0.855731225 -0.689060489 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Lysosome 0.556521739 0.835968379 0.625482625 kegg kegg NA NA no no no no no no Chemokine signaling pathway Lysosome 0.429565217 0.60770751 0 kegg kegg NA NA no no no no no no Clostridium Lysosome 0 0.465594101 0 Genus kegg 0.925 NA no no no no no no Coprococcus Lysosome -0.471304348 0 0 butyrate-producing Genus kegg 0.612 NA no no no no no no Cysteine and methionine metabolism Lysosome -0.632173913 0 -0.607979408 kegg kegg NA NA no no no no no no DNA replication Lysosome -0.659130435 -0.633399209 -0.508365508 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Lysosome -0.466956522 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Lysosome 0 -0.630434783 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Lysosome 0 -0.603754941 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Lysosome -0.696521739 -0.758893281 -0.535907336 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Lysosome 0.463478261 0.506916996 0.478249678 kegg kegg NA NA no no no no no no Fatty acid degradation Lysosome 0 0 0.441184041 kegg kegg NA NA no no no no no no Fatty acid metabolism Lysosome 0 0.441699605 0.437065637 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Lysosome 0 0 0.5997426 kegg kegg NA NA no no no no no no Galactose metabolism Lysosome 0 0 0.469240669 kegg kegg NA NA no no no no no no Glutathione metabolism Lysosome 0 -0.473320158 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Lysosome 0 -0.471343874 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Lysosome -0.462608696 -0.612648221 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Lysosome 0.650434783 0 0.487258687 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Lysosome 0 0 -0.400772201 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Lysosome 0.885217391 0.73715415 0.474903475 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Lysosome 0 -0.482213439 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Lysosome -0.529565217 -0.731225296 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Lysosome 0.435652174 0.533596838 0.60978121 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Lysosome -0.434782609 0 0 kegg kegg NA NA no no no no no no Homologous recombination Lysosome -0.623478261 -0.664031621 -0.588416988 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Lysosome 0 -0.437747036 0 kegg kegg NA NA no no no no no no Lysine degradation Lysosome -0.44 -0.708498024 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Lysosome 0 -0.562252964 0 kegg kegg NA NA no no no no no no Mismatch repair Lysosome -0.504347826 -0.515810277 -0.427027027 kegg kegg NA NA no no no no no no Mitophagy - animal Lysosome 0 -0.458498024 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Lysosome 0 -0.669960474 -0.58970399 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Lysosome -0.660869565 -0.605731225 -0.603346203 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Lysosome 0.469565217 0.846837945 0.788674389 kegg kegg NA NA up up up no no no Nicotinate and nicotinamide metabolism Lysosome 0.582608696 0.618577075 0.764736165 kegg kegg NA NA no no no no no no Nitrogen metabolism Lysosome 0.554782609 0.442687747 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Lysosome -0.666956522 -0.698616601 -0.567052767 kegg kegg NA NA no no no no no no One carbon pool by folate Lysosome -0.74173913 -0.696640316 -0.491377091 kegg kegg NA NA no no no no no no Oocyte meiosis Lysosome -0.425217391 0 -0.564478764 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Lysosome -0.435652174 -0.802371542 -0.424453024 kegg kegg NA NA no no no no no no p53 signaling pathway Lysosome -0.42173913 -0.601778656 -0.441698842 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Lysosome 0.488695652 0.612648221 0.748777349 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Lysosome 0 -0.479249012 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Lysosome 0.67826087 0.911067194 0.855598456 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Lysosome 0 -0.581027668 -0.431402831 kegg kegg NA NA no no no no no no Platinum drug resistance Lysosome -0.528695652 -0.551383399 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Lysosome -0.431304348 -0.538537549 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Lysosome 0.413913043 0.615612648 0.572715573 kegg kegg NA NA no no no no no no Prevotella Lysosome -0.523307137 0 0 acetate-producing Genus kegg 0.287 NA no no no no no no Propanoate metabolism Lysosome -0.497391304 0 -0.456885457 kegg kegg NA NA no no no no no no Protein export Lysosome -0.531304348 0 -0.418532819 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Lysosome -0.629565217 -0.698616601 -0.51042471 kegg kegg NA NA no no no no no no Purine metabolism Lysosome 0 -0.707509881 0 kegg kegg NA NA no no no no no no Pyramidobacter Lysosome 0 0 -0.401484853 Genus kegg 0.45 NA no no no no no no Pyrimidine metabolism Lysosome 0 -0.571146245 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Lysosome -0.6 -0.43083004 -0.417503218 kegg kegg NA NA no no no no no no Retinol metabolism Lysosome 0 -0.48715415 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Lysosome -0.772173913 -0.836956522 -0.613384813 kegg kegg NA NA no no no no no no RNA degradation Lysosome 0 -0.617588933 -0.513770914 kegg kegg NA NA no no no no no no RNA polymerase Lysosome -0.708695652 -0.845849802 -0.491891892 kegg kegg NA NA no no no no no no RNA transport Lysosome -0.555652174 0 -0.47001287 kegg kegg NA NA no no no no no no Ruminococcus Lysosome -0.483478261 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Selenocompound metabolism Lysosome -0.411304348 -0.641304348 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Lysosome 0.873913043 0.445652174 0.589446589 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Lysosome 0.405217391 0.660079051 0 kegg kegg NA NA no no no no no no Spliceosome Lysosome -0.655652174 -0.660079051 -0.601801802 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Lysosome 0.459130435 0.507905138 0.764478764 kegg kegg NA NA no no no no no no Steroid biosynthesis Lysosome -0.530434783 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Lysosome -0.553043478 -0.563241107 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Lysosome -0.483478261 0 -0.411325611 kegg kegg NA NA no no no no no no Tyrosine metabolism Lysosome -0.409565217 -0.421936759 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Lysosome 0 -0.466403162 -0.445559846 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Lysosome 0 -0.578063241 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Lysosome -0.457391304 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Lysosome -0.528695652 -0.514822134 -0.429086229 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Lysosome 0 0.496047431 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Malaria 0 -0.633399209 -0.423423423 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Malaria 0.46173913 0.720355731 0.663577864 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Malaria 0 0 -0.486229086 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Malaria 0 0 -0.414929215 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Malaria 0 -0.508893281 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Malaria 0.559130435 0.423913043 0.687001287 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Malaria 0.533913043 0 0.453024453 kegg kegg NA NA no no no no no no Arginine biosynthesis Malaria 0 0.473320158 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Malaria 0 -0.564229249 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Malaria 0 -0.493083004 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Malaria 0 -0.659090909 0 kegg kegg NA NA no no no no no no Bile secretion Malaria 0 0 0.566023166 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Malaria 0 0 0.58043758 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Malaria 0 -0.41798419 0 kegg kegg NA NA no no no no no no Butanoate metabolism Malaria 0 -0.576086957 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Malaria 0 0.589920949 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Malaria 0 0 -0.564993565 kegg kegg NA NA no no no no no no Carbon metabolism Malaria 0 -0.497035573 0 kegg kegg NA NA no no no no no no Cell cycle Malaria -0.444347826 0 0 kegg kegg NA NA no no no no no no Chagas disease Malaria 0 0.591897233 0 kegg kegg NA NA no no no no no no Cholinergic synapse Malaria 0 0 -0.545688546 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Malaria 0 -0.557312253 0 kegg kegg NA NA no no no no no no Cocaine addiction Malaria 0 0.486166008 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Malaria 0 0 0.40952381 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Malaria 0 0.541501976 0 kegg kegg NA NA no no no no no no DNA replication Malaria 0 -0.495059289 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Malaria 0 -0.520750988 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Malaria 0 -0.526679842 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Malaria 0 0 -0.61003861 kegg kegg NA NA no no no no no no Estrogen signaling pathway Malaria 0 -0.468379447 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Malaria -0.407826087 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Malaria 0 -0.518774704 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Malaria 0 0 -0.43011583 kegg kegg NA NA no no no no no no Ferroptosis Malaria 0.686956522 0.743083004 0.84967825 kegg kegg NA NA no no no no no no Focal adhesion Malaria 0 -0.51284585 -0.452252252 kegg kegg NA NA no up up no no no Folate biosynthesis Malaria -0.603478261 -0.466403162 0 kegg kegg NA NA no no no no no no GABAergic synapse Malaria 0 0.43972332 0 kegg kegg NA NA no up up no no no Gap junction Malaria 0 0.468379447 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Malaria 0.446086957 0.511857708 0.455083655 kegg kegg NA NA no up up no no no Glutathione metabolism Malaria 0.61826087 0 0.611068211 kegg kegg NA NA no no no no no no Glycerolipid metabolism Malaria 0 0 -0.580694981 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Malaria 0 0 -0.491377091 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Malaria 0 0 0.582754183 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Malaria 0 0 -0.426512227 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Malaria 0 -0.622529644 -0.549034749 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Malaria 0 0 -0.606692407 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Malaria 0 -0.506916996 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Malaria 0 0.456521739 0 kegg kegg NA NA no no no no no no GnRH secretion Malaria 0 0 -0.547490347 kegg kegg NA NA no up up no no no Hedgehog signaling pathway Malaria 0 0 -0.500643501 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Malaria 0 -0.756916996 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Malaria 0 -0.51284585 -0.438610039 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Malaria 0 0 -0.564736165 kegg kegg NA NA no no no no no no Histidine metabolism Malaria 0 -0.43972332 0 kegg kegg NA NA no no no no no no Homologous recombination Malaria -0.446086957 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Malaria -0.490434783 0 -0.556241956 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Malaria -0.463478261 0 0 kegg kegg NA NA no no no no no no Long-term depression Malaria 0 0.494071146 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Malaria 0.47826087 0.60770751 0.678764479 kegg kegg NA NA no no no no no no Lysine degradation Malaria 0 0 -0.494208494 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Malaria 0 0 -0.49034749 kegg kegg NA NA no no no no no no MAPK signaling pathway Malaria -0.529565217 0 -0.532046332 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Malaria 0 -0.612648221 0 kegg kegg NA NA no no no no no no Mineral absorption Malaria 0.626086957 0.625494071 0.845559846 kegg kegg NA NA no no no no no no Mitophagy - animal Malaria 0.453913043 0.460474308 0.94002574 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Malaria 0 -0.466403162 -0.433719434 kegg kegg NA NA no no no no no no Necroptosis Malaria 0.646086957 0.772727273 0.858429858 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Malaria -0.410434783 0 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Malaria 0 0.597826087 0.428314028 kegg kegg NA NA no no no no no no Non-homologous end-joining Malaria 0 -0.500988142 0 kegg kegg NA NA no no no no no no Notch signaling pathway Malaria 0 0 -0.611583012 kegg kegg NA NA no no no no no no One carbon pool by folate Malaria 0 -0.519762846 0 kegg kegg NA NA no no no no no no Oocyte meiosis Malaria 0 -0.443675889 0 kegg kegg NA NA no no no no no no Other glycan degradation Malaria 0 0 -0.680823681 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Malaria -0.406956522 0 -0.493436293 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Malaria 0 0.443675889 0.446589447 kegg kegg NA NA no up up no no no "Parathyroid hormone synthesis, secretion and action" Malaria 0 0 0.471557272 kegg kegg NA NA no no no no no no Parkinson disease Malaria 0 0 0.764221364 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Malaria 0 0 0.755469755 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Malaria 0 -0.555335968 0 kegg kegg NA NA no no no no no no Peroxisome Malaria 0 0 0.432947233 kegg kegg NA NA no no no no no no Phenylalanine metabolism Malaria 0 -0.636363636 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Malaria 0 -0.457509881 -0.521235521 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Malaria 0.543478261 0 0.673873874 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Malaria 0 -0.460474308 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Malaria -0.480869565 0 -0.526383526 kegg kegg NA NA no no no no no no Proteasome Malaria 0 -0.462450593 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Malaria 0 0 0.647361647 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Malaria 0 -0.457509881 0 kegg kegg NA NA no no no no no no Purine metabolism Malaria 0.731304348 0 0.842213642 kegg kegg NA NA no no no no no no Pyrimidine metabolism Malaria 0 -0.467391304 0 kegg kegg NA NA no no no no no no Ras signaling pathway Malaria 0 -0.476284585 0 yes kegg kegg NA NA no up up no no no Regulation of lipolysis in adipocytes Malaria 0 0.41798419 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Malaria 0 0.601778656 0 kegg kegg NA NA no no no no no no Renin secretion Malaria 0 0 0.425740026 kegg kegg NA NA no no no no no no Retinol metabolism Malaria 0 -0.51284585 0 kegg kegg NA NA no no no no no no Ribosome Malaria 0 0 0.411325611 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Malaria 0 0.432806324 0 kegg kegg NA NA no no no no no no RNA degradation Malaria 0 0 -0.442213642 kegg kegg NA NA no no no no no no Roseburia Malaria 0.414782609 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Shigellosis Malaria 0.422608696 0.500988142 0.927413127 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Malaria 0 0 -0.469498069 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Malaria -0.420869565 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Malaria 0 0 -0.504247104 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Malaria 0 0 -0.676705277 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Malaria 0 0 -0.436550837 kegg kegg NA NA no no no no no no Steroid biosynthesis Malaria 0 -0.500988142 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Malaria 0 -0.599802372 0 kegg kegg NA NA no no no no no no Sulfur metabolism Malaria 0.483478261 0 0.596911197 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Malaria 0 -0.429841897 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Malaria -0.605217391 0 0 kegg kegg NA NA no no no no no no Taste transduction Malaria -0.44173913 0 -0.537966538 kegg kegg NA NA no no up no no no TGF-beta signaling pathway Malaria 0 0 -0.434491634 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Malaria 0 0 -0.491119691 kegg kegg NA NA no no no no no no Th17 cell differentiation Malaria 0 0 -0.446589447 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Malaria 0 0 -0.506306306 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Malaria 0.507826087 0 0.540540541 kegg kegg NA NA no no no no no no Tryptophan metabolism Malaria 0 -0.708498024 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Malaria 0 0 -0.456628057 kegg kegg NA NA no no no no no no Tyrosine metabolism Malaria 0 -0.489130435 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Malaria 0 -0.540513834 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Malaria 0 0 0.927413127 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Malaria 0 -0.615612648 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Malaria 0 -0.531620553 -0.536936937 kegg kegg NA NA no no no no no no VEGF signaling pathway Malaria 0 0 -0.613384813 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Malaria 0 0 -0.452252252 kegg kegg NA NA no no no no no no Wnt signaling pathway Malaria 0 0 -0.554182754 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Mannose type O-glycan biosynthesis 0 0 -0.631917632 kegg kegg NA NA no no no no no no Arginine and proline metabolism Mannose type O-glycan biosynthesis -0.517391304 0 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Mannose type O-glycan biosynthesis 0 0 -0.725611326 kegg kegg NA NA no no no no no no beta-Alanine metabolism Mannose type O-glycan biosynthesis -0.51826087 0 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Mannose type O-glycan biosynthesis -0.444347826 0 0 kegg kegg NA NA no no no no no no Fatty acid degradation Mannose type O-glycan biosynthesis -0.533913043 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Mannose type O-glycan biosynthesis -0.527826087 -0.492094862 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Mannose type O-glycan biosynthesis -0.451304348 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Mannose type O-glycan biosynthesis -0.46 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Mannose type O-glycan biosynthesis 0 0 -0.481853282 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Mannose type O-glycan biosynthesis -0.670434783 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Mannose type O-glycan biosynthesis -0.434782609 0 0 kegg kegg NA NA no no no no no no Lysine degradation Mannose type O-glycan biosynthesis 0.646956522 0.897233202 0.904504505 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Mannose type O-glycan biosynthesis -0.542608696 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Mannose type O-glycan biosynthesis 0 0.462450593 0.594851995 kegg kegg NA NA no no no no no no Other glycan degradation Mannose type O-glycan biosynthesis 0 0.630434783 0.607207207 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Mannose type O-glycan biosynthesis 0.579130435 0.791501976 0.862548263 kegg kegg NA NA no no no no no no Oxidative phosphorylation Mannose type O-glycan biosynthesis 0.42173913 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Mannose type O-glycan biosynthesis -0.437391304 0 0.484427284 kegg kegg NA NA no no no no no no Pentose phosphate pathway Mannose type O-glycan biosynthesis 0 -0.587944664 -0.61956242 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Mannose type O-glycan biosynthesis -0.476521739 -0.472332016 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Mannose type O-glycan biosynthesis -0.62173913 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Mannose type O-glycan biosynthesis 0 0.508893281 0.656885457 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Mannose type O-glycan biosynthesis -0.507826087 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Mannose type O-glycan biosynthesis -0.632173913 0 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Mannose type O-glycan biosynthesis 0 0.56027668 0.593564994 kegg kegg NA NA no no no no no no Tryptophan metabolism Mannose type O-glycan biosynthesis -0.426956522 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Mannose type O-glycan biosynthesis -0.613043478 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Mannose type O-glycan biosynthesis 0 0.548418972 0.555984556 kegg kegg NA NA no no no no no no ABC transporters MAPK signaling pathway 0 0.550395257 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" MAPK signaling pathway 0 0.445652174 0 kegg kegg NA NA no no no no no no Alistipes MAPK signaling pathway -0.627953586 0.453196041 0 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism MAPK signaling pathway 0 0.524703557 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism MAPK signaling pathway 0 0.561264822 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis MAPK signaling pathway 0 0.501976285 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism MAPK signaling pathway 0 0 -0.575546976 kegg kegg NA NA no no no no no no Base excision repair MAPK signaling pathway 0.41826087 0.450592885 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors MAPK signaling pathway 0 0 -0.446589447 kegg kegg NA NA no no no no no no Collinsella MAPK signaling pathway 0 0 -0.577605251 Genus kegg 0.128 NA no no no no no no Fanconi anemia pathway MAPK signaling pathway 0.45826087 0.559288538 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis MAPK signaling pathway 0 0.45256917 0 kegg kegg NA NA no no no no no no Fatty acid degradation MAPK signaling pathway 0.426086957 0.710474308 0 kegg kegg NA NA no no no no no no Fatty acid metabolism MAPK signaling pathway 0 0.588932806 0 kegg kegg NA NA no no no no no no Folate biosynthesis MAPK signaling pathway 0.429565217 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism MAPK signaling pathway 0 0.500988142 0 kegg kegg NA NA no no no no no no Galactose metabolism MAPK signaling pathway 0 0.583992095 0 kegg kegg NA NA no no no no no no Glutathione metabolism MAPK signaling pathway -0.56 0 -0.615958816 kegg kegg NA NA no no no no no no Glycerolipid metabolism MAPK signaling pathway 0 0.66798419 0.470785071 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism MAPK signaling pathway 0 0.637351779 0.446589447 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" MAPK signaling pathway 0 0 -0.407979408 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate MAPK signaling pathway 0 0.42687747 0.451480051 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin MAPK signaling pathway 0 0 0.532818533 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation MAPK signaling pathway 0 0 0.407979408 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis MAPK signaling pathway 0.548695652 0 0 kegg kegg NA NA no no no no no no Histidine metabolism MAPK signaling pathway 0 0.471343874 0 kegg kegg NA NA no no no no no no Homologous recombination MAPK signaling pathway 0.589565217 0.631422925 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism MAPK signaling pathway 0.562608696 0.776679842 0.519433719 kegg kegg NA NA no no no no no no Lysine degradation MAPK signaling pathway 0 0.490118577 0.464864865 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis MAPK signaling pathway 0 0 0.400772201 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis MAPK signaling pathway 0.491304348 0.754940711 0 kegg kegg NA NA no no no no no no Oscillospira MAPK signaling pathway 0 0.579051383 0 LPS-producing Genus kegg 0.62 NA no no no no no no Other glycan degradation MAPK signaling pathway 0 0.571146245 0.411325611 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis MAPK signaling pathway 0 0.449604743 0.429343629 kegg kegg NA NA no no no no no no Oxidative phosphorylation MAPK signaling pathway 0 -0.695652174 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis MAPK signaling pathway 0.49826087 0 0 kegg kegg NA NA no no dn no no no Parabacteroides MAPK signaling pathway 0 0.46541502 0 Genus kegg 4.19E-05 NA no up up no no no Platinum drug resistance MAPK signaling pathway 0.50173913 0.695652174 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism MAPK signaling pathway 0 0 -0.466666667 kegg kegg NA NA no no no no no no Protein export MAPK signaling pathway 0 -0.447628458 0 kegg kegg NA NA no no no no no no Ribosome MAPK signaling pathway 0 -0.561264822 0 kegg kegg NA NA no no no no no no RNA degradation MAPK signaling pathway 0 0 0.432175032 kegg kegg NA NA no no no no no no Selenocompound metabolism MAPK signaling pathway 0.45826087 0.679841897 0 kegg kegg NA NA no no no no no no Spliceosome MAPK signaling pathway 0 0.618577075 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism MAPK signaling pathway 0 0.481225296 0 kegg kegg NA NA no no no no no no Sulfur metabolism MAPK signaling pathway 0 0 -0.410810811 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism MAPK signaling pathway 0 0.472332016 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis MAPK signaling pathway 0.55826087 0 0 kegg kegg NA NA no no no no no no ABC transporters Maturity onset diabetes of the young 0 0 0.60952381 kegg kegg NA NA no up up no up no Amino sugar and nucleotide sugar metabolism Maturity onset diabetes of the young -0.42 0 0.426769627 kegg kegg NA NA no no no no up no AMPK signaling pathway Maturity onset diabetes of the young 0 0 -0.441956242 kegg kegg NA NA no no no no up no Antifolate resistance Maturity onset diabetes of the young 0 0 0.493693694 kegg kegg NA NA no no no no up no Ascorbate and aldarate metabolism Maturity onset diabetes of the young 0 0.504940711 0.458172458 kegg kegg NA NA no no no no up no Biosynthesis of amino acids Maturity onset diabetes of the young -0.489565217 -0.422924901 0 kegg kegg NA NA no no no no up no Carbon metabolism Maturity onset diabetes of the young -0.522608696 0 0 kegg kegg NA NA no no no no up no Cell adhesion molecules Maturity onset diabetes of the young 0 -0.584980237 0 kegg kegg NA NA no no no no up no Cellular senescence Maturity onset diabetes of the young 0 -0.603754941 0 kegg kegg NA NA no no no no up no Cholinergic synapse Maturity onset diabetes of the young 0 0 0.545688546 kegg kegg NA NA no no no no up no Circadian entrainment Maturity onset diabetes of the young 0 0.509881423 0 kegg kegg NA NA no up up no up no Complement and coagulation cascades Maturity onset diabetes of the young -0.443478261 0 0 kegg kegg NA NA no no no no up no Cortisol synthesis and secretion Maturity onset diabetes of the young 0 0.425889328 0 kegg kegg NA NA no no up no up no Cushing syndrome Maturity onset diabetes of the young 0 0.423913043 0 kegg kegg NA NA no no up no up no Cysteine and methionine metabolism Maturity onset diabetes of the young -0.511304348 0 0 kegg kegg NA NA no no no no up no Cytokine-cytokine receptor interaction Maturity onset diabetes of the young -0.431304348 0 0 kegg kegg NA NA no no no no up no Dopaminergic synapse Maturity onset diabetes of the young 0 0.477272727 0 kegg kegg NA NA no up no no up no Drug metabolism - cytochrome P450 Maturity onset diabetes of the young -0.453913043 0 0 kegg kegg NA NA no no no no up no Drug metabolism - other enzymes Maturity onset diabetes of the young 0 0 0.522265122 kegg kegg NA NA no no no no up no Endocrine resistance Maturity onset diabetes of the young 0 0.440711462 0 kegg kegg NA NA no no no no up no Endocytosis Maturity onset diabetes of the young 0 -0.599802372 0 kegg kegg NA NA no no no no up no Estrogen signaling pathway Maturity onset diabetes of the young -0.471304348 0.468379447 -0.483397683 kegg kegg NA NA no no no no up no Ether lipid metabolism Maturity onset diabetes of the young 0.474782609 0.59486166 0 kegg kegg NA NA no no no no up no Fatty acid elongation Maturity onset diabetes of the young -0.412173913 0 0 kegg kegg NA NA no no no no up no Fc gamma R-mediated phagocytosis Maturity onset diabetes of the young 0 0 -0.417760618 kegg kegg NA NA no no no no up no Focal adhesion Maturity onset diabetes of the young -0.45826087 0 0 kegg kegg NA NA no up up no up no Galactose metabolism Maturity onset diabetes of the young 0 0 0.583526384 kegg kegg NA NA no no no no up no Gap junction Maturity onset diabetes of the young 0 0 -0.567567568 kegg kegg NA NA no no no no up no Glutamatergic synapse Maturity onset diabetes of the young 0 0 -0.443500644 kegg kegg NA NA no up up no up no Glycerolipid metabolism Maturity onset diabetes of the young 0 0 0.546718147 kegg kegg NA NA no no up no up no Glycerophospholipid metabolism Maturity onset diabetes of the young 0.594782609 0 0.583268983 kegg kegg NA NA no no up no up no Glycolysis / Gluconeogenesis Maturity onset diabetes of the young -0.655652174 0 0 kegg kegg NA NA no no no no up no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Maturity onset diabetes of the young 0 0 0.451737452 kegg kegg NA NA no no no no up no Glycosaminoglycan degradation Maturity onset diabetes of the young 0 0 0.472586873 kegg kegg NA NA no no up no up no Glycosphingolipid biosynthesis - ganglio series Maturity onset diabetes of the young 0.408695652 0 0 kegg kegg NA NA no no no no up no Glycosphingolipid biosynthesis - lacto and neolacto series Maturity onset diabetes of the young 0.617391304 0 0 kegg kegg NA NA no no no no up no GnRH secretion Maturity onset diabetes of the young 0 0 0.421621622 kegg kegg NA NA no up up no up no Hedgehog signaling pathway Maturity onset diabetes of the young 0.508695652 0 0.55984556 kegg kegg NA NA no no no no up no Hippo signaling pathway - multiple species Maturity onset diabetes of the young 0 0 0.517889318 kegg kegg NA NA no no no no up no Inositol phosphate metabolism Maturity onset diabetes of the young 0 0 0.569111969 kegg kegg NA NA no no no no up no Leukocyte transendothelial migration Maturity onset diabetes of the young -0.453043478 0 0 kegg kegg NA NA no no no no up no Longevity regulating pathway Maturity onset diabetes of the young 0.550434783 0 0 kegg kegg NA NA no no no no up no Lysine degradation Maturity onset diabetes of the young 0 0 0.552123552 kegg kegg NA NA no no no no up no Mannose type O-glycan biosynthesis Maturity onset diabetes of the young 0.464347826 0 0.577606178 kegg kegg NA NA no no no no up no Metabolism of xenobiotics by cytochrome P450 Maturity onset diabetes of the young -0.426956522 0 0 kegg kegg NA NA no no no no up no mRNA surveillance pathway Maturity onset diabetes of the young 0.503478261 0 0 kegg kegg NA NA no no no no up no Mucin type O-glycan biosynthesis Maturity onset diabetes of the young -0.513043478 0 0 kegg kegg NA NA no no no no up no Natural killer cell mediated cytotoxicity Maturity onset diabetes of the young -0.489565217 -0.625494071 0 kegg kegg NA NA no no no no up no Neuroactive ligand-receptor interaction Maturity onset diabetes of the young -0.449565217 0 0 kegg kegg NA NA up up up no up no Neurotrophin signaling pathway Maturity onset diabetes of the young 0 -0.453557312 0 kegg kegg NA NA no no no no up no Non-homologous end-joining Maturity onset diabetes of the young -0.476521739 0 0 kegg kegg NA NA no no no no up no Notch signaling pathway Maturity onset diabetes of the young 0.728695652 0 0.72046332 kegg kegg NA NA no no no no up no One carbon pool by folate Maturity onset diabetes of the young 0 0 0.451222651 kegg kegg NA NA no no no no up no Other glycan degradation Maturity onset diabetes of the young 0 0 0.578635779 kegg kegg NA NA no no no no up no Other types of O-glycan biosynthesis Maturity onset diabetes of the young 0 0 0.589446589 kegg kegg NA NA no no no no up no Ovarian steroidogenesis Maturity onset diabetes of the young 0 0 -0.446074646 kegg kegg NA NA no up up no up no p53 signaling pathway Maturity onset diabetes of the young 0.507826087 0 0 kegg kegg NA NA no no no no up no Pentose and glucuronate interconversions Maturity onset diabetes of the young -0.520869565 0 0 kegg kegg NA NA no no no no up no Phagosome Maturity onset diabetes of the young 0 -0.524703557 0 kegg kegg NA NA no no no no up no Phosphatidylinositol signaling system Maturity onset diabetes of the young 0.483478261 0 0.501158301 kegg kegg NA NA no no no no up no Propanoate metabolism Maturity onset diabetes of the young -0.540869565 0 0 kegg kegg NA NA no no no no up no Pyrimidine metabolism Maturity onset diabetes of the young 0 0 0.662290862 kegg kegg NA NA no no no no up no Regulation of actin cytoskeleton Maturity onset diabetes of the young -0.613043478 0 0 kegg kegg NA NA no no no no up no Regulation of lipolysis in adipocytes Maturity onset diabetes of the young 0 0 -0.420849421 kegg kegg NA NA no no no no up no Renin secretion Maturity onset diabetes of the young 0 0 -0.441184041 kegg kegg NA NA no no no no up no Retinol metabolism Maturity onset diabetes of the young -0.533043478 0 0 kegg kegg NA NA no no no no up no RNA degradation Maturity onset diabetes of the young 0.486086957 0 0 kegg kegg NA NA no no no no up no RNA transport Maturity onset diabetes of the young -0.49826087 0 0 kegg kegg NA NA no no no no up no Selenocompound metabolism Maturity onset diabetes of the young 0 0 0.557786358 kegg kegg NA NA no no no no up no Serotonergic synapse Maturity onset diabetes of the young 0 0 -0.469498069 kegg kegg NA NA no no no no up no SNARE interactions in vesicular transport Maturity onset diabetes of the young 0 0 0.528700129 kegg kegg NA NA no no no no up no Sphingolipid metabolism Maturity onset diabetes of the young 0 0 0.497297297 kegg kegg NA NA no no no no up no Sphingolipid signaling pathway Maturity onset diabetes of the young 0 -0.480237154 0 kegg kegg NA NA no no no no up no Starch and sucrose metabolism Maturity onset diabetes of the young 0 0 0.443758044 kegg kegg NA NA no no no no up no Steroid hormone biosynthesis Maturity onset diabetes of the young 0 0.532608696 0.458429858 kegg kegg NA NA no no no no up no T cell receptor signaling pathway Maturity onset diabetes of the young -0.414782609 -0.505928854 0 kegg kegg NA NA no no no no up no Taste transduction Maturity onset diabetes of the young 0 0 0.606949807 kegg kegg NA NA no no up no up no Taurine and hypotaurine metabolism Maturity onset diabetes of the young 0.44 0 0.456885457 kegg kegg NA NA no no no no up no Th1 and Th2 cell differentiation Maturity onset diabetes of the young 0.428695652 0 0 kegg kegg NA NA no no no no up no Type I diabetes mellitus Maturity onset diabetes of the young 0 -0.511857708 0 kegg kegg NA NA no no no no up no Type II diabetes mellitus Maturity onset diabetes of the young 0 0 0.484169884 kegg kegg NA NA no no no no up no Viral protein interaction with cytokine and cytokine receptor Maturity onset diabetes of the young -0.473043478 0 0 kegg kegg NA NA no no no no up no Wnt signaling pathway Maturity onset diabetes of the young 0 0 0.463577864 kegg kegg NA NA no no no no up no 16:0/16:1-PC+blood MCP-1(MCAF) 0 0 0.535338346 yes serum_phospholipids serum_cytokines 0.00283 0.0633 up up no dn no no 16:0/18:1-PC+blood MCP-1(MCAF) 0 0 0.583458647 yes serum_phospholipids serum_cytokines 6.15E-07 0.0633 up up up dn no no 16:0/18:2-PC+blood MCP-1(MCAF) 0.696969697 0 0 yes serum_phospholipids serum_cytokines 3.24E-06 0.0633 no up up dn no no 16:1/16:0-PC+blood MCP-1(MCAF) 0.76969697 0 0 yes serum_phospholipids serum_cytokines 0.0215 0.0633 no up up dn no no 18:0/16:0-PC+blood MCP-1(MCAF) 0 0 0.648120301 yes serum_phospholipids serum_cytokines 9.64E-07 0.0633 up up up dn no no 18:1/16:0-PC+blood MCP-1(MCAF) 0.757575758 0 0 yes serum_phospholipids serum_cytokines 2.43E-05 0.0633 no up up dn no no 20:3/16:0-PC+blood MCP-1(MCAF) 0.648484848 0 0 yes serum_phospholipids serum_cytokines 0.00405 0.0633 no up up dn no no 20:4-LPC+blood MCP-1(MCAF) 0 0 -0.515789474 yes serum_phospholipids serum_cytokines 0.949 0.0633 no no no dn no no 24:1+blood MCP-1(MCAF) 0.806060606 0 0 yes serum_fattyacid serum_cytokines 0.00582 0.0633 no dn dn dn no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" MCP-1(MCAF) 0 0 -0.477192982 yes urine_cometabolism serum_cytokines 0.0125 0.0633 up up no dn no no AA+blood MCP-1(MCAF) 0 0 -0.566917293 yes serum_ARA serum_cytokines 0.212 0.0633 no no no dn no no ACA+blood MCP-1(MCAF) 0.833995557 0 0 yes serum_bileacids serum_cytokines 0.338 0.0633 no no no dn no no Acetic acid+stool MCP-1(MCAF) 0.83030303 0 0 yes yes stool_scfa serum_cytokines 0.0656 0.0633 dn no no dn no no Adherens junction MCP-1(MCAF) 0 0 -0.48877942 yes kegg serum_cytokines NA 0.0633 no no no dn no no AMPK signaling pathway MCP-1(MCAF) 0.791208791 0 0 yes kegg serum_cytokines NA 0.0633 no no no dn no no Apoptosis MCP-1(MCAF) 0 0 -0.462506842 yes kegg serum_cytokines NA 0.0633 no no no dn no no Betaine+blood MCP-1(MCAF) 0 0 -0.566917293 yes serum_choline serum_cytokines 0.857 0.0633 no no no dn no no Butyric acid+stool MCP-1(MCAF) 0.733333333 0 0 yes yes stool_scfa serum_cytokines 0.102 0.0633 dn no no dn no no Butyricicoccus MCP-1(MCAF) -0.628970902 0 0 butyrate-producing yes Genus serum_cytokines 0.852 0.0633 no no no dn no no Clostridium MCP-1(MCAF) -0.580119351 0 0 yes Genus serum_cytokines 0.925 0.0633 no no no dn no no d18:0-16:0-SM+blood MCP-1(MCAF) 0 0 -0.452631579 yes serum_phospholipids serum_cytokines 0.202 0.0633 no no no dn no no d18:1-14:0-SM+blood MCP-1(MCAF) -0.733333333 0 0 yes serum_phospholipids serum_cytokines 0.94 0.0633 no no no dn no no d18:1-16:0-SM+blood MCP-1(MCAF) 0 0 -0.487218045 yes serum_phospholipids serum_cytokines 0.14 0.0633 no no no dn no no d18:1-16:1-SM+blood MCP-1(MCAF) -0.709090909 0 0 yes serum_phospholipids serum_cytokines 0.2 0.0633 no no no dn no no d18:1-20:0-SM+blood MCP-1(MCAF) -0.721212121 0 0 yes serum_phospholipids serum_cytokines 0.933 0.0633 no no no dn no no d18:1-22:0-SM+blood MCP-1(MCAF) -0.878787879 0 0 yes serum_phospholipids serum_cytokines 0.522 0.0633 no no no dn no no d18:1-22:1-SM+blood MCP-1(MCAF) -0.684848485 0 0 yes serum_phospholipids serum_cytokines 0.222 0.0633 no no no dn no no DCA+blood MCP-1(MCAF) 0 0 0.460150376 yes serum_bileacids serum_cytokines 0.122 0.0633 no no no dn no no DL-Indole-3-lactic acid+urine MCP-1(MCAF) -0.733333333 0 0 yes urine_cometabolism serum_cytokines 0.00552 0.0633 up up no dn no no Eotaxin MCP-1(MCAF) 0 0.509090909 0 yes serum_cytokines serum_cytokines 0.393 0.0633 no no no dn no no Ethanolamine+blood MCP-1(MCAF) 0.660606061 0 0 yes serum_aminoacids serum_cytokines 0.122 0.0633 up no no dn no no Fc epsilon RI signaling pathway MCP-1(MCAF) 0 0 -0.53256705 yes kegg serum_cytokines NA 0.0633 no no no dn no no Fluid shear stress and atherosclerosis MCP-1(MCAF) 0 0 -0.559386973 yes kegg serum_cytokines NA 0.0633 no no no dn no no GM-CSF MCP-1(MCAF) 0 0 -0.515461624 yes yes serum_cytokines serum_cytokines 0.0124 0.0633 up no no dn no no HDCA+stool MCP-1(MCAF) 0.733333333 0 0 yes stool_bileacids serum_cytokines 0.176 0.0633 no no no dn no no Hematopoietic cell lineage MCP-1(MCAF) 0.565934066 0 0 yes kegg serum_cytokines NA 0.0633 no no no dn no no Hepatocellular carcinoma MCP-1(MCAF) 0 0 -0.401751505 yes kegg serum_cytokines NA 0.0633 no no no dn no no IL-4 MCP-1(MCAF) 0 0.614285714 0 yes serum_cytokines serum_cytokines 0.858 0.0633 no no no dn no no IL-9 MCP-1(MCAF) -0.642857143 0 0 yes serum_cytokines serum_cytokines 0.906 0.0633 no no no dn no no Inflammatory bowel disease MCP-1(MCAF) 0.554945055 0 0 yes kegg serum_cytokines NA 0.0633 no no no dn no no Influenza A MCP-1(MCAF) 0 0 -0.428024083 yes kegg serum_cytokines NA 0.0633 no no no dn no no L-Asparagine+blood MCP-1(MCAF) 0.648484848 0 0 yes serum_aminoacids serum_cytokines 0.784 0.0633 no no no dn no no L-Tryptophan+stool MCP-1(MCAF) -0.648484848 0 0 yes stool_cometabolism serum_cytokines 0.557 0.0633 no no no dn no no Leukocyte transendothelial migration MCP-1(MCAF) 0 0 -0.445539135 yes kegg serum_cytokines NA 0.0633 no no no dn no no Malaria MCP-1(MCAF) 0.686813187 0 0 yes kegg serum_cytokines NA 0.0633 no no no dn no no Measles MCP-1(MCAF) -0.708791209 0 0 yes kegg serum_cytokines NA 0.0633 no no no dn no no Mineral absorption MCP-1(MCAF) 0.56043956 0 0 yes kegg serum_cytokines NA 0.0633 no no no dn no no Necroptosis MCP-1(MCAF) 0.576923077 0 0 yes kegg serum_cytokines NA 0.0633 no no no dn no no NF-kappa B signaling pathway MCP-1(MCAF) -0.571428571 0 0 yes kegg serum_cytokines NA 0.0633 no no no dn no no Parabacteroides MCP-1(MCAF) 0.637362637 0 0 yes Genus serum_cytokines 4.19E-05 0.0633 no up up dn no no Pathogenic Escherichia coli infection MCP-1(MCAF) 0 0 -0.448275862 yes kegg serum_cytokines NA 0.0633 no no no dn no no Propionic acid+stool MCP-1(MCAF) 0.890909091 0 0 yes yes stool_scfa serum_cytokines 0.0436 0.0633 dn no up dn no no Protein processing in endoplasmic reticulum MCP-1(MCAF) 0 0 0.54077723 yes kegg serum_cytokines NA 0.0633 no no no dn no no Purine metabolism MCP-1(MCAF) 0.730769231 0 0 yes kegg serum_cytokines NA 0.0633 no no no dn no no Rap1 signaling pathway MCP-1(MCAF) 0 0 -0.439518336 yes kegg serum_cytokines NA 0.0633 no no no dn no no Slackia MCP-1(MCAF) 0 0 0.402716029 yes Genus serum_cytokines 0.94 0.0633 no no no dn no no T cell receptor signaling pathway MCP-1(MCAF) -0.598901099 0 0 yes kegg serum_cytokines NA 0.0633 no no no dn no no total_stool_scfa+stool MCP-1(MCAF) 0.806060606 0 0 yes stool_scfa serum_cytokines 0.0534 0.0633 dn no up dn no no Yersinia infection MCP-1(MCAF) 0 0 -0.565955118 yes kegg serum_cytokines NA 0.0633 no no no dn no no ABC transporters Measles 0.424347826 0 0 kegg kegg NA NA no up up no no no Alcoholism Measles 0 -0.616600791 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Measles -0.547826087 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Measles 0 0 0.507850708 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Measles -0.486086957 0 0 kegg kegg NA NA no no no no no no Autophagy - animal Measles 0.56 0 0 kegg kegg NA NA no no no no no no Autophagy - other Measles 0.596521739 0 0 kegg kegg NA NA no no no no no no Bile secretion Measles 0 -0.583992095 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Measles 0.551304348 0 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Measles 0.417391304 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Measles -0.426086957 0 0 kegg kegg NA NA no no no no no no Chagas disease Measles 0.406956522 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Measles 0.424347826 0 0 kegg kegg NA NA no no no no no no Circadian entrainment Measles 0 -0.57312253 0 kegg kegg NA NA no up up no no no Cytosolic DNA-sensing pathway Measles 0 0.424901186 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Measles 0 -0.493083004 0 kegg kegg NA NA no up no no no no EGFR tyrosine kinase inhibitor resistance Measles 0 0 0.545431145 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Measles -0.488695652 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Measles 0 -0.415019763 0 kegg kegg NA NA no no no no no no Folate biosynthesis Measles 0.507826087 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Measles 0.406956522 0 0 kegg kegg NA NA no no no no no no Gap junction Measles -0.48173913 -0.454545455 0 kegg kegg NA NA no no no no no no Gastric acid secretion Measles -0.433043478 0 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Measles -0.523478261 -0.438735178 0 kegg kegg NA NA no up up no no no Glutathione metabolism Measles -0.52 0 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Measles -0.413043478 0 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Measles -0.413913043 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Measles -0.413043478 0 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Measles -0.505217391 0 0 kegg kegg NA NA no no no no no no Hepatitis B Measles 0.717391304 0 0 kegg kegg NA NA no no no no no no Hepatitis C Measles 0.717391304 0.605731225 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Measles 0 0 0.602831403 kegg kegg NA NA no no no no no no Hippo signaling pathway Measles -0.453043478 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Measles 0.405217391 0 0 kegg kegg NA NA no no no no no no Insulin resistance Measles 0.645217391 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Measles 0 0 0.503732304 kegg kegg NA NA no no no no no no Legionellosis Measles 0 0.559288538 0.446846847 kegg kegg NA NA no no no no no no Leishmaniasis Measles 0 0.416007905 0 kegg kegg NA NA no no no no no no Malaria Measles -0.586956522 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Measles 0.546086957 0 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Measles 0 -0.482213439 0 kegg kegg NA NA no up no no no no Morphine addiction Measles 0 -0.548418972 0 kegg kegg NA NA no up up no no no mTOR signaling pathway Measles 0 0 0.544144144 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Measles 0.440869565 0 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Measles 0.49826087 0 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Measles 0 -0.434782609 0 kegg kegg NA NA no up up no no no Phagosome Measles -0.42 0 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Measles 0.699130435 0.631422925 0.467696268 yes kegg kegg NA NA no up up no no no Platelet activation Measles -0.428695652 -0.514822134 0 kegg kegg NA NA no no no no no no Prevotella Measles 0 -0.413635022 0 acetate-producing Genus kegg 0.287 NA no no no no no no Progesterone-mediated oocyte maturation Measles 0.551304348 0 0 kegg kegg NA NA no no no no no no Proteasome Measles 0 0 0.416473616 kegg kegg NA NA no no no no no no Purine metabolism Measles -0.55826087 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Measles 0 -0.519762846 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Measles 0 -0.519762846 0 kegg kegg NA NA no no no no no no Ribosome Measles 0 0 0.521750322 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Measles 0.692173913 0 0 kegg kegg NA NA no no no no no no RNA transport Measles 0.408695652 0.428853755 0.404118404 kegg kegg NA NA no no no no no no Roseburia Measles -0.422608696 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Salivary secretion Measles -0.597391304 -0.548418972 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Measles 0.406086957 0 0 kegg kegg NA NA no no no no no no Serotonergic synapse Measles 0 -0.517786561 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Measles 0.459130435 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Measles 0.433913043 0 0 kegg kegg NA NA no no no no no no Spliceosome Measles 0.510434783 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Measles -0.467826087 0 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Measles 0.847826087 0.645256917 0 kegg kegg NA NA no no no no no no Taste transduction Measles 0.413043478 0 0 kegg kegg NA NA no no up no no no Th1 and Th2 cell differentiation Measles 0 0.52173913 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Measles 0 0.648221344 0 kegg kegg NA NA no no no no no no Thiamine metabolism Measles 0.568695652 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Measles -0.493913043 0 0 kegg kegg NA NA no no no no no no TNF signaling pathway Measles 0.509565217 0 0 kegg kegg NA NA no no no no no no Toxoplasmosis Measles 0 0.468379447 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Measles -0.502608696 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Measles -0.406956522 -0.458498024 0 kegg kegg NA NA no no no no no no ABC transporters Melanogenesis -0.549565217 0 0 kegg kegg NA NA no up up no no no Adherens junction Melanogenesis 0 0.545454545 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Melanogenesis 0.66 0.850790514 0.881853282 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Melanogenesis -0.683478261 -0.791501976 -0.424195624 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Melanogenesis -0.51826087 -0.625494071 -0.621621622 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Melanogenesis 0 0 -0.519433719 kegg kegg NA NA no no no no no no AMPK signaling pathway Melanogenesis 0 0.440711462 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Melanogenesis -0.406956522 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Melanogenesis 0 0.656126482 0 kegg kegg NA NA no no no no no no Apoptosis Melanogenesis -0.433043478 -0.618577075 -0.441698842 kegg kegg NA NA no no no no no no Arginine and proline metabolism Melanogenesis -0.705217391 -0.786561265 -0.468211068 kegg kegg NA NA no up no no no no Arginine biosynthesis Melanogenesis -0.671304348 -0.738142292 -0.42007722 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Melanogenesis 0 0 -0.443500644 kegg kegg NA NA no no no no no no Autophagy - animal Melanogenesis -0.409565217 -0.683794466 -0.400772201 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Melanogenesis -0.406086957 -0.660079051 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Melanogenesis -0.50173913 -0.753952569 -0.576576577 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Melanogenesis 0 0.454545455 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Melanogenesis 0 -0.669960474 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Melanogenesis 0.645217391 0.766798419 0.786357786 kegg kegg NA NA no up up no no no cAMP signaling pathway Melanogenesis 0 0 0.534105534 yes kegg kegg NA NA no up up no no no Carbon metabolism Melanogenesis 0 0 -0.634234234 kegg kegg NA NA no no no no no no Cardiac muscle contraction Melanogenesis 0.543478261 0.837944664 0.408494208 kegg kegg NA NA no no up no no no Cell adhesion molecules Melanogenesis 0 -0.550395257 0 kegg kegg NA NA no no no no no no Cell cycle Melanogenesis 0 0.505928854 0.42007722 kegg kegg NA NA no no no no no no Cellular senescence Melanogenesis 0 -0.453557312 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Melanogenesis 0 -0.703557312 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Melanogenesis 0 -0.52173913 0 kegg kegg NA NA no no no no no no Circadian entrainment Melanogenesis 0.725217391 0.705533597 0.737709138 kegg kegg NA NA no up up no no no Circadian rhythm Melanogenesis 0 0.421936759 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Melanogenesis -0.439130435 -0.707509881 0 kegg kegg NA NA no no no no no no Coprococcus Melanogenesis 0 0 -0.41559946 butyrate-producing Genus kegg 0.612 NA no no no no no no Cysteine and methionine metabolism Melanogenesis 0 0.420948617 0 kegg kegg NA NA no no no no no no DNA replication Melanogenesis 0 0.483201581 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Melanogenesis 0.593043478 0.755928854 0.857142857 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Melanogenesis 0 0.4743083 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Melanogenesis 0 0.486166008 -0.619047619 kegg kegg NA NA no no no no no no ECM-receptor interaction Melanogenesis 0 0 0.475675676 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Melanogenesis 0 0.578063241 0 kegg kegg NA NA no no no no no no Endocrine resistance Melanogenesis 0.707826087 0.476284585 0.724581725 kegg kegg NA NA no no no no no no Endocytosis Melanogenesis 0 -0.524703557 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Melanogenesis 0.411304348 0.515810277 0.572972973 kegg kegg NA NA no no no no no no Ether lipid metabolism Melanogenesis 0.437391304 0.509881423 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Melanogenesis -0.653043478 -0.779644269 -0.44015444 kegg kegg NA NA no no no no no no Fatty acid degradation Melanogenesis -0.655652174 -0.750988142 -0.631917632 kegg kegg NA NA no no no no no no Fatty acid metabolism Melanogenesis -0.648695652 -0.740118577 -0.522779923 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Melanogenesis 0 -0.691699605 -0.470527671 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Melanogenesis -0.475652174 -0.708498024 -0.43011583 kegg kegg NA NA no no no no no no Focal adhesion Melanogenesis 0 0.435770751 0 kegg kegg NA NA no up up no no no Folate biosynthesis Melanogenesis 0 0.421936759 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Melanogenesis 0 -0.531620553 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Melanogenesis -0.505217391 -0.435770751 -0.73951094 kegg kegg NA NA no no no no no no GABAergic synapse Melanogenesis -0.534782609 -0.574110672 0 kegg kegg NA NA no up up no no no Galactose metabolism Melanogenesis -0.479130435 -0.648221344 -0.674388674 kegg kegg NA NA no no no no no no Gap junction Melanogenesis 0.725217391 0 0.526640927 kegg kegg NA NA no no no no no no Glutamatergic synapse Melanogenesis 0.506086957 0 0.448648649 kegg kegg NA NA no up up no no no Glutathione metabolism Melanogenesis 0 0.593873518 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Melanogenesis -0.444347826 -0.422924901 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Melanogenesis 0 0.443675889 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Melanogenesis -0.52 -0.591897233 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Melanogenesis 0.532173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Melanogenesis 0 -0.538537549 -0.555469755 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Melanogenesis -0.763478261 -0.764822134 -0.517889318 kegg kegg NA NA no no no no no no GnRH signaling pathway Melanogenesis 0.727826087 0.704545455 0.884427284 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Melanogenesis 0.42173913 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Melanogenesis 0 0.455533597 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Melanogenesis 0.514782609 0.605731225 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Melanogenesis -0.466956522 -0.652173913 -0.473359073 kegg kegg NA NA no no no no no no Histidine metabolism Melanogenesis 0 0 -0.596138996 kegg kegg NA NA no no no no no no IL-17 signaling pathway Melanogenesis -0.524347826 -0.657114625 -0.516087516 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Melanogenesis 0.805217391 0.949604743 0.93951094 kegg kegg NA NA no no no no no no Insulin secretion Melanogenesis 0.75826087 0.721343874 0.811840412 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Melanogenesis 0 0.591897233 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Melanogenesis 0 -0.585968379 0 kegg kegg NA NA no no no no no no Long-term depression Melanogenesis 0.764347826 0.423913043 0.718146718 kegg kegg NA NA no no no no no no Lysosome Melanogenesis 0 -0.544466403 -0.677477477 kegg kegg NA NA no no no no no no MAPK signaling pathway Melanogenesis 0 -0.543478261 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Melanogenesis 0 0.427865613 0 kegg kegg NA NA no no no no no no Mitophagy - animal Melanogenesis 0.508695652 0.690711462 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Melanogenesis 0 0.690711462 0.441184041 kegg kegg NA NA no no no no no no mTOR signaling pathway Melanogenesis 0 0.549407115 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Melanogenesis 0 0.624505929 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Melanogenesis 0 -0.460474308 0 kegg kegg NA NA no no no no no no Necroptosis Melanogenesis 0.447826087 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Melanogenesis 0 -0.625494071 -0.516859717 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Melanogenesis 0 -0.485177866 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Melanogenesis -0.446086957 -0.598814229 -0.428314028 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Melanogenesis -0.662608696 -0.684782609 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Melanogenesis -0.686956522 -0.714426877 -0.580694981 kegg kegg NA NA no no no no no no Nitrogen metabolism Melanogenesis -0.566956522 -0.643280632 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Melanogenesis -0.734782609 -0.766798419 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Melanogenesis 0 0.416007905 0 kegg kegg NA NA no no no no no no Olfactory transduction Melanogenesis 0 -0.605731225 -0.588159588 kegg kegg NA NA no no no no no no One carbon pool by folate Melanogenesis 0 0.467391304 0 kegg kegg NA NA no no no no no no Oocyte meiosis Melanogenesis 0 0 0.472329472 kegg kegg NA NA no no no no no no Oscillospira Melanogenesis 0 -0.502964427 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Melanogenesis -0.664347826 -0.77173913 -0.467696268 kegg kegg NA NA no no no no no no Other glycan degradation Melanogenesis -0.671304348 0 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Melanogenesis 0.812173913 0.584980237 0.634749035 kegg kegg NA NA no up up no no no Oxidative phosphorylation Melanogenesis 0.52 0.833003953 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Melanogenesis -0.509565217 -0.747035573 -0.667953668 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Melanogenesis 0 0.513833992 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Melanogenesis -0.42173913 -0.672924901 -0.644272844 kegg kegg NA NA no no no no no no Peroxisome Melanogenesis -0.69826087 -0.800395257 -0.411583012 kegg kegg NA NA no no no no no no Phagosome Melanogenesis 0 -0.542490119 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Melanogenesis 0.411304348 0 0 kegg kegg NA NA no no no no no no Phototransduction Melanogenesis 0.525217391 0 0 kegg kegg NA NA no no no no no no Platelet activation Melanogenesis 0.469565217 0.492094862 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Melanogenesis -0.610434783 -0.802371542 0 kegg kegg NA NA no no no no no no Prevotella Melanogenesis 0 0 0.503406166 acetate-producing Genus kegg 0.287 NA no no no no no no Proteasome Melanogenesis 0 0 -0.471042471 kegg kegg NA NA no no no no no no Protein export Melanogenesis 0 0.634387352 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Melanogenesis 0.416521739 0.610671937 0 kegg kegg NA NA no no no no no no Purine metabolism Melanogenesis 0 0.466403162 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Melanogenesis -0.417391304 0.448616601 -0.401029601 kegg kegg NA NA no no no no no no Pyruvate metabolism Melanogenesis 0 0.501976285 0 kegg kegg NA NA no no no no no no Ras signaling pathway Melanogenesis 0 0.581027668 0 yes kegg kegg NA NA no up up no no no Renin-angiotensin system Melanogenesis 0 -0.625494071 -0.499099099 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Melanogenesis 0 0.761857708 0 kegg kegg NA NA no no up no no no Ribosome Melanogenesis 0.435652174 0.730237154 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Melanogenesis 0 0.451581028 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Melanogenesis -0.599130435 -0.707509881 0 kegg kegg NA NA no no no no no no RNA degradation Melanogenesis 0 0.719367589 0 kegg kegg NA NA no no no no no no RNA polymerase Melanogenesis 0 0.631422925 0 kegg kegg NA NA no no no no no no RNA transport Melanogenesis 0 0.419960474 0 kegg kegg NA NA no no no no no no Serotonergic synapse Melanogenesis 0.414782609 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Melanogenesis -0.539130435 -0.593873518 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Melanogenesis 0 0 -0.576833977 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Melanogenesis 0 -0.441699605 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Melanogenesis -0.602608696 -0.749011858 -0.804633205 kegg kegg NA NA no no no no no no Steroid biosynthesis Melanogenesis 0.479130435 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Melanogenesis 0 -0.660079051 -0.714543115 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Melanogenesis 0 -0.542490119 0 kegg kegg NA NA no no no no no no Taste transduction Melanogenesis 0 0.43972332 0 kegg kegg NA NA no no up no no no TGF-beta signaling pathway Melanogenesis 0.499130435 0.640316206 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Melanogenesis 0 -0.450592885 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Melanogenesis 0 -0.483201581 0 kegg kegg NA NA no no no no no no Thermogenesis Melanogenesis 0.625217391 0.852766798 0.422651223 kegg kegg NA NA no no no no no no TNF signaling pathway Melanogenesis 0 -0.558300395 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Melanogenesis -0.439130435 -0.711462451 0 yes kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Melanogenesis 0.579130435 0.743083004 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Melanogenesis 0.717391304 0.837944664 0.679279279 kegg kegg NA NA no no no no no no VEGF signaling pathway Melanogenesis 0 -0.414031621 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Melanogenesis 0.597391304 0.717391304 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Melanoma -0.69826087 -0.663043478 0 kegg kegg NA NA no no no no no no Adherens junction Melanoma -0.472173913 -0.627470356 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Melanoma 0 0.651185771 0 kegg kegg NA NA no no no no no no African trypanosomiasis Melanoma 0.47826087 0.431818182 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Melanoma 0.449565217 0.740118577 0.664607465 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Melanoma 0 0.641304348 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Melanoma 0.857391304 0.757905138 0.753153153 kegg kegg NA NA no no no no no no Alzheimer disease Melanoma 0 -0.468379447 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Melanoma -0.523478261 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Melanoma -0.488695652 -0.58201581 0 kegg kegg NA NA no no no no no no Amoebiasis Melanoma 0 0.67687747 0 kegg kegg NA NA no no no no no no Amphetamine addiction Melanoma 0 -0.497035573 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Melanoma 0 -0.526679842 0 kegg kegg NA NA no no no no no no Antifolate resistance Melanoma -0.468695652 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Melanoma 0 -0.574110672 0 kegg kegg NA NA no no no no no no Apoptosis Melanoma 0 0.633399209 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Melanoma -0.593043478 0 -0.547232947 kegg kegg NA NA no no no no no no Arginine and proline metabolism Melanoma 0 0.645256917 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Melanoma 0 0.618577075 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Melanoma -0.486956522 -0.600790514 0 kegg kegg NA NA no no no no no no Autophagy - animal Melanoma 0.84 0.876482213 0.806177606 kegg kegg NA NA no no no no no no Autophagy - other Melanoma 0.624347826 0.505928854 0.651994852 kegg kegg NA NA no no no no no no Axon guidance Melanoma 0.547826087 0 0.548262548 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Melanoma 0.449565217 0.736166008 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Melanoma -0.522608696 -0.585968379 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Melanoma 0 0 0.475675676 kegg kegg NA NA no no no no no no beta-Alanine metabolism Melanoma -0.706086957 -0.71541502 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Melanoma -0.720869565 -0.456521739 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Melanoma -0.606086957 -0.595849802 0 kegg kegg NA NA no no no no no no Butanoate metabolism Melanoma -0.736521739 -0.843873518 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Melanoma 0.859130435 0.786561265 0.639124839 kegg kegg NA NA no no no no no no cAMP signaling pathway Melanoma 0.662608696 0.618577075 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Melanoma 0.843478261 0.788537549 0.701158301 kegg kegg NA NA no no no no no no Carbon metabolism Melanoma -0.596521739 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Melanoma 0 -0.43972332 0 kegg kegg NA NA no no up no no no Cell cycle Melanoma 0 -0.414031621 0 kegg kegg NA NA no no no no no no Cellular senescence Melanoma 0 0.470355731 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Melanoma 0.683478261 0.472332016 0.466924067 kegg kegg NA NA no no no no no no Chagas disease Melanoma 0.640869565 0.82312253 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Melanoma 0 0.564229249 0 kegg kegg NA NA no no no no no no Cholinergic synapse Melanoma 0.770434783 0 0.635778636 kegg kegg NA NA no no no no no no Circadian entrainment Melanoma 0 -0.58201581 -0.507593308 kegg kegg NA NA no up up no no no Circadian rhythm Melanoma 0.629565217 0 0.483655084 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Melanoma -0.643478261 -0.864624506 0 kegg kegg NA NA no no no no no no Colorectal cancer Melanoma 0.613913043 0 0.710939511 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Melanoma 0 -0.47826087 -0.465379665 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Melanoma 0 -0.76284585 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Melanoma 0 0 -0.47979408 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Melanoma 0 0.574110672 0 kegg kegg NA NA no no no no no no DNA replication Melanoma 0 -0.732213439 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Melanoma -0.409565217 -0.878458498 -0.47027027 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Melanoma -0.606956522 -0.849802372 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Melanoma -0.424347826 0 0 kegg kegg NA NA no up up no no no Endometrial cancer Melanoma 0.828695652 0.935770751 0.848906049 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Melanoma 0 0.631422925 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Melanoma 0.750434783 0.791501976 0.813642214 kegg kegg NA NA no no no no no no Estrogen signaling pathway Melanoma 0 -0.734189723 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Melanoma 0 0.617588933 0 kegg kegg NA NA no no no no no no Fatty acid elongation Melanoma -0.680869565 -0.630434783 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Melanoma 0.626956522 0.779644269 0.517374517 kegg kegg NA NA no no no no no no Ferroptosis Melanoma 0 0 -0.411325611 kegg kegg NA NA no no no no no no Focal adhesion Melanoma -0.468695652 -0.723320158 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Melanoma 0.523478261 0.572134387 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Melanoma -0.497391304 0 0 kegg kegg NA NA no no no no no no GABAergic synapse Melanoma 0.427826087 0.566205534 0 kegg kegg NA NA no up up no no no Galactose metabolism Melanoma -0.48173913 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Melanoma -0.488695652 -0.692687747 -0.483912484 kegg kegg NA NA no no no no no no Glioma Melanoma 0.717391304 0.601778656 0.654311454 kegg kegg NA NA no no no no no no Glucagon signaling pathway Melanoma 0 -0.485177866 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Melanoma 0 0.480237154 0 kegg kegg NA NA no up up no no no Glutathione metabolism Melanoma -0.489565217 -0.481225296 -0.640669241 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Melanoma -0.594782609 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Melanoma -0.650434783 -0.752964427 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Melanoma 0.45826087 0.807312253 0.434749035 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Melanoma -0.547826087 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Melanoma 0 0 0.427027027 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Melanoma 0 -0.497035573 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Melanoma 0.414782609 0 0.442728443 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Melanoma 0 0.624505929 0 kegg kegg NA NA no no no no no no GnRH secretion Melanoma 0.793913043 0.809288538 0.761904762 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Melanoma 0.591304348 0.600790514 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Melanoma 0 0 0.524066924 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Melanoma 0 -0.60770751 0 kegg kegg NA NA no no no no no no Hepatitis B Melanoma 0.771304348 0.815217391 0.762934363 kegg kegg NA NA no no no no no no Hepatitis C Melanoma 0.66173913 0.625494071 0.61029601 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Melanoma 0 -0.475296443 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Melanoma -0.546086957 -0.666007905 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Melanoma 0 0.483201581 0.444530245 kegg kegg NA NA no no no no no no Histidine metabolism Melanoma -0.426956522 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Melanoma 0 0.493083004 0 kegg kegg NA NA no no no no no no Huntington disease Melanoma 0 -0.483201581 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Melanoma 0.470434783 0.448616601 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Melanoma 0 -0.47826087 0 kegg kegg NA NA no no no no no no Insulin resistance Melanoma 0.7 0.842885375 0.62960103 kegg kegg NA NA no no no no no no Insulin signaling pathway Melanoma 0 -0.508893281 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Melanoma 0 0.68972332 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Melanoma -0.427826087 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Melanoma 0.469565217 -0.497035573 0.453281853 kegg kegg NA NA no no up no no no Longevity regulating pathway Melanoma 0.42 0 0 kegg kegg NA NA no no no no no no Lysine degradation Melanoma 0 0 0.404118404 kegg kegg NA NA no no no no no no Malaria Melanoma 0 0.441699605 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Melanoma 0 0 0.709395109 kegg kegg NA NA no no no no no no Melanogenesis Melanoma 0 -0.471343874 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Melanoma -0.464347826 -0.904150198 -0.507850708 kegg kegg NA NA no no no no no no MicroRNAs in cancer Melanoma 0.489565217 0.897233202 0.853796654 kegg kegg NA NA no no no no no no Mineral absorption Melanoma 0 0 -0.476705277 kegg kegg NA NA no no no no no no Mismatch repair Melanoma -0.526086957 -0.688735178 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Melanoma 0.430434783 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Melanoma 0 -0.619565217 0 kegg kegg NA NA no no no no no no Necroptosis Melanoma 0 0 -0.402316602 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Melanoma 0.745217391 0.781620553 0.592277992 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Melanoma 0.405217391 0.821146245 0.556499356 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Melanoma 0 0.68083004 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Melanoma 0 0.652173913 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Melanoma 0 0.68972332 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Melanoma -0.674782609 -0.683794466 0 kegg kegg NA NA no no no no no no Notch signaling pathway Melanoma 0.56173913 0.568181818 0.487516088 kegg kegg NA NA no no no no no no Nucleotide excision repair Melanoma 0 -0.662055336 0 kegg kegg NA NA no no no no no no One carbon pool by folate Melanoma 0 -0.651185771 0 kegg kegg NA NA no no no no no no Oocyte meiosis Melanoma 0 -0.644268775 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Melanoma 0 0.636363636 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Melanoma 0 0 0.416473616 kegg kegg NA NA no no no no no no Oxidative phosphorylation Melanoma 0 -0.462450593 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Melanoma -0.413913043 -0.424901186 -0.509137709 kegg kegg NA NA no no no no no no p53 signaling pathway Melanoma 0.444347826 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Melanoma 0.624347826 0 0.493951094 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Melanoma 0 0.447628458 0 kegg kegg NA NA no no dn no no no Parkinson disease Melanoma 0 0 -0.543371943 kegg kegg NA NA no no no no no no Pathways in cancer Melanoma 0.633913043 0.7243083 0.451737452 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Melanoma 0 0 -0.538223938 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Melanoma -0.7 -0.793478261 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Melanoma -0.783478261 -0.842885375 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Melanoma 0.477391304 0 0.489060489 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Melanoma 0 0.755928854 0 kegg kegg NA NA no up up no no no Phototransduction Melanoma 0 -0.717391304 0 kegg kegg NA NA no no no no no no Platelet activation Melanoma -0.487826087 -0.575098814 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Melanoma -0.535652174 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Melanoma 0 0.650197628 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Melanoma -0.60173913 -0.696640316 0 kegg kegg NA NA no no no no no no Prion disease Melanoma 0 -0.533596838 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Melanoma 0.549565217 0 0.577863578 kegg kegg NA NA no no no no no no Prolactin signaling pathway Melanoma 0.806956522 0.704545455 0.641184041 kegg kegg NA NA no no no no no no Propanoate metabolism Melanoma 0 -0.740118577 0 kegg kegg NA NA no no no no no no Prostate cancer Melanoma 0.796521739 0.827075099 0.588159588 kegg kegg NA NA no no no no no no Proteasome Melanoma 0 -0.743083004 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Melanoma 0 0 0.505019305 yes kegg kegg NA NA no up up no no no Protein export Melanoma 0 -0.593873518 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Melanoma 0 -0.590909091 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Melanoma 0 -0.459486166 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Melanoma 0 -0.700592885 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Melanoma -0.474782609 -0.64229249 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Melanoma -0.475652174 -0.777667984 -0.454568855 kegg kegg NA NA no no no no no no Ras signaling pathway Melanoma 0 -0.493083004 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Melanoma -0.487826087 -0.645256917 -0.482882883 kegg kegg NA NA no no no no no no Relaxin signaling pathway Melanoma 0.566086957 0.658102767 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Melanoma 0.606086957 0 0 kegg kegg NA NA no no no no no no Renin secretion Melanoma 0 -0.617588933 -0.444787645 kegg kegg NA NA no no no no no no Retinol metabolism Melanoma -0.46 -0.673913043 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Melanoma 0 -0.527667984 0 kegg kegg NA NA no no up no no no Ribosome Melanoma 0 -0.485177866 -0.466924067 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Melanoma 0 -0.448616601 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Melanoma 0.676521739 0.841897233 0.483912484 kegg kegg NA NA no no no no no no RNA degradation Melanoma 0 -0.495059289 0 kegg kegg NA NA no no no no no no RNA polymerase Melanoma 0 -0.532608696 0 kegg kegg NA NA no no no no no no Shigellosis Melanoma 0 0 -0.512741313 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Melanoma 0.717391304 0.502964427 0.711711712 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Melanoma 0 0.470355731 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Melanoma 0.846086957 0.631422925 0.587129987 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Melanoma 0.66 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Melanoma 0 0.45256917 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Melanoma 0 -0.7243083 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Melanoma -0.59826087 -0.722332016 0 kegg kegg NA NA no no no no no no Sulfur metabolism Melanoma -0.564347826 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Melanoma -0.462608696 -0.621541502 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Melanoma 0.442608696 0.532608696 0.537966538 kegg kegg NA NA no no no no no no Taste transduction Melanoma 0 -0.595849802 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Melanoma 0 0.568181818 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Melanoma 0 -0.550395257 0 kegg kegg NA NA no no no no no no Thermogenesis Melanoma 0 -0.517786561 -0.442213642 kegg kegg NA NA no no no no no no Thiamine metabolism Melanoma 0 -0.57312253 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Melanoma 0 -0.481225296 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Melanoma 0 0 -0.462805663 kegg kegg NA NA no no no no no no Tight junction Melanoma -0.582608696 -0.622529644 -0.594851995 kegg kegg NA NA no no no no no no TNF signaling pathway Melanoma 0.757391304 0.836956522 0.515315315 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Melanoma 0.731304348 0.772727273 0 yes kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Melanoma 0.653913043 0.82312253 0.645559846 kegg kegg NA NA no no no no no no Tryptophan metabolism Melanoma -0.684347826 -0.777667984 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Melanoma 0.923478261 0.854743083 0.707078507 kegg kegg NA NA no no no no no no Tyrosine metabolism Melanoma -0.711304348 -0.822134387 -0.499356499 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Melanoma -0.63826087 -0.731225296 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Melanoma 0 0 -0.423166023 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Melanoma -0.642608696 -0.833003953 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Melanoma 0 -0.473320158 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Melanoma 0 -0.52173913 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Melanoma 0 -0.424901186 -0.462548263 kegg kegg NA NA no no no no no no VEGF signaling pathway Melanoma 0.810434783 0.791501976 0.77014157 kegg kegg NA NA no no no no no no Vibrio cholerae infection Melanoma -0.455652174 -0.619565217 -0.518404118 kegg kegg NA NA no no no no no no Viral carcinogenesis Melanoma 0 0.519762846 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Melanoma 0 0 -0.534362934 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Melanoma 0.413913043 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Melanoma 0 -0.477272727 0.404375804 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Metabolism of xenobiotics by cytochrome P450 0 -0.706521739 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Metabolism of xenobiotics by cytochrome P450 0.526956522 0 0.524581725 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Metabolism of xenobiotics by cytochrome P450 0.543478261 0 0.431402831 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Metabolism of xenobiotics by cytochrome P450 0.413913043 0.612648221 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Metabolism of xenobiotics by cytochrome P450 0.54 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Metabolism of xenobiotics by cytochrome P450 0 -0.651185771 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Metabolism of xenobiotics by cytochrome P450 0 -0.723320158 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Metabolism of xenobiotics by cytochrome P450 0 0.68972332 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Metabolism of xenobiotics by cytochrome P450 0.499130435 0.751976285 0.577606178 kegg kegg NA NA no no no no no no Butanoate metabolism Metabolism of xenobiotics by cytochrome P450 0.406086957 0.877470356 0.485199485 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Metabolism of xenobiotics by cytochrome P450 0.555652174 0.925889328 0.402574003 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Metabolism of xenobiotics by cytochrome P450 0.55826087 0.792490119 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Metabolism of xenobiotics by cytochrome P450 0 -0.683794466 0 kegg kegg NA NA no no no no no no Fatty acid elongation Metabolism of xenobiotics by cytochrome P450 0.493043478 0.675889328 0.605148005 kegg kegg NA NA no no no no no no Folate biosynthesis Metabolism of xenobiotics by cytochrome P450 0 0.477272727 0 kegg kegg NA NA no no no no no no Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 0.495652174 0.454545455 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Metabolism of xenobiotics by cytochrome P450 -0.436521739 0 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Metabolism of xenobiotics by cytochrome P450 0.653043478 0.769762846 0.533333333 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Metabolism of xenobiotics by cytochrome P450 0 -0.791501976 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolism of xenobiotics by cytochrome P450 0 0.528656126 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Metabolism of xenobiotics by cytochrome P450 -0.610434783 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Metabolism of xenobiotics by cytochrome P450 0 0.556324111 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Metabolism of xenobiotics by cytochrome P450 0.496521739 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Metabolism of xenobiotics by cytochrome P450 -0.683478261 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Metabolism of xenobiotics by cytochrome P450 0 -0.708498024 0 kegg kegg NA NA no no no no no no Histidine metabolism Metabolism of xenobiotics by cytochrome P450 0 0 0.414671815 kegg kegg NA NA no no no no no no Linoleic acid metabolism Metabolism of xenobiotics by cytochrome P450 0.634782609 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Metabolism of xenobiotics by cytochrome P450 -0.662608696 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Metabolism of xenobiotics by cytochrome P450 0.506956522 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Metabolism of xenobiotics by cytochrome P450 0 0.730237154 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Metabolism of xenobiotics by cytochrome P450 0 -0.703557312 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Metabolism of xenobiotics by cytochrome P450 0 -0.749011858 0 kegg kegg NA NA no no no no no no One carbon pool by folate Metabolism of xenobiotics by cytochrome P450 0 0.708498024 0 kegg kegg NA NA no no no no no no Other glycan degradation Metabolism of xenobiotics by cytochrome P450 0 0 0.405920206 kegg kegg NA NA no no no no no no Oxidative phosphorylation Metabolism of xenobiotics by cytochrome P450 0 0.447628458 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Metabolism of xenobiotics by cytochrome P450 0 -0.503952569 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Metabolism of xenobiotics by cytochrome P450 0.693913043 0.872529644 0.51016731 kegg kegg NA NA no no no no no no Phenylalanine metabolism Metabolism of xenobiotics by cytochrome P450 0.489565217 0.886363636 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Metabolism of xenobiotics by cytochrome P450 0.515652174 0.649209486 0.511196911 kegg kegg NA NA no no no no no no Propanoate metabolism Metabolism of xenobiotics by cytochrome P450 0.611304348 0.761857708 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Metabolism of xenobiotics by cytochrome P450 0.551304348 0.695652174 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Metabolism of xenobiotics by cytochrome P450 0.540869565 0.795454545 0 kegg kegg NA NA no no no no no no Retinol metabolism Metabolism of xenobiotics by cytochrome P450 0.685217391 0.65513834 0.518918919 kegg kegg NA NA no no no no no no Sphingolipid metabolism Metabolism of xenobiotics by cytochrome P450 0 0 0.431917632 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Metabolism of xenobiotics by cytochrome P450 0 -0.491106719 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Metabolism of xenobiotics by cytochrome P450 0 0.700592885 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Metabolism of xenobiotics by cytochrome P450 0.642608696 0.751976285 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Metabolism of xenobiotics by cytochrome P450 0 0.647233202 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Metabolism of xenobiotics by cytochrome P450 0 -0.533596838 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Metabolism of xenobiotics by cytochrome P450 0 0.424901186 0 kegg kegg NA NA no no no no no no Thiamine metabolism Metabolism of xenobiotics by cytochrome P450 0 0.585968379 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Metabolism of xenobiotics by cytochrome P450 0.504347826 0.848814229 0.433976834 kegg kegg NA NA no up no no no no Tyrosine metabolism Metabolism of xenobiotics by cytochrome P450 0.655652174 0.830039526 0.452252252 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Metabolism of xenobiotics by cytochrome P450 0.464347826 0.778656126 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Metabolism of xenobiotics by cytochrome P450 0.486956522 0.875494071 0.526126126 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Metabolism of xenobiotics by cytochrome P450 0 0.615612648 0 kegg kegg NA NA no no no no no no Methanobrevibacter Methanosphaera 0 0.700831113 0 Genus Genus 0.629 0.0703 no no no no no no 2-Oxocarboxylic acid metabolism MicroRNAs in cancer 0 -0.554347826 0 kegg kegg NA NA no no no no no no ABC transporters MicroRNAs in cancer 0 0.43972332 0 kegg kegg NA NA no up up no no no Adherens junction MicroRNAs in cancer 0 -0.730237154 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway MicroRNAs in cancer 0 0.637351779 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes MicroRNAs in cancer 0 -0.441699605 0 kegg kegg NA NA no no up no no no African trypanosomiasis MicroRNAs in cancer 0 0.476284585 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications MicroRNAs in cancer 0 0.794466403 0.692921493 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" MicroRNAs in cancer 0 0.701581028 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption MicroRNAs in cancer 0 0.625494071 0.702187902 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism MicroRNAs in cancer 0 0.416996047 0 kegg kegg NA NA no no no no no no Alzheimer disease MicroRNAs in cancer 0 -0.624505929 0 kegg kegg NA NA no no no no no no Amoebiasis MicroRNAs in cancer 0 0.663043478 0 kegg kegg NA NA no no no no no no Amphetamine addiction MicroRNAs in cancer 0 -0.571146245 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis MicroRNAs in cancer 0 -0.652173913 0 kegg kegg NA NA no no no no no no Apelin signaling pathway MicroRNAs in cancer 0 -0.692687747 0 kegg kegg NA NA no no no no no no Apoptosis MicroRNAs in cancer 0 0.677865613 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism MicroRNAs in cancer -0.54 0 -0.706821107 kegg kegg NA NA no no no no no no Arginine and proline metabolism MicroRNAs in cancer 0 0.733201581 0 kegg kegg NA NA no up no no no no Arginine biosynthesis MicroRNAs in cancer 0 0.647233202 0 kegg kegg NA NA no no no no no no Autophagy - animal MicroRNAs in cancer 0.525217391 0.927865613 0.678507079 kegg kegg NA NA no no no no no no Autophagy - other MicroRNAs in cancer 0 0.637351779 0.715572716 kegg kegg NA NA no no no no no no Axon guidance MicroRNAs in cancer 0 0 0.441956242 kegg kegg NA NA no up up no no no B cell receptor signaling pathway MicroRNAs in cancer 0.494782609 0.826086957 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells MicroRNAs in cancer 0 -0.646245059 0 kegg kegg NA NA no no no no no no Bacteroides MicroRNAs in cancer 0 -0.424901186 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors MicroRNAs in cancer 0 0 0.436550837 kegg kegg NA NA no no no no no no beta-Alanine metabolism MicroRNAs in cancer 0 -0.550395257 0 kegg kegg NA NA no no no no no no Bifidobacterium MicroRNAs in cancer 0 -0.425954748 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Bile secretion MicroRNAs in cancer 0 0 -0.442728443 kegg kegg NA NA no no no no no no Biosynthesis of amino acids MicroRNAs in cancer 0 0 -0.401287001 kegg kegg NA NA no no no no no no Biosynthesis of cofactors MicroRNAs in cancer 0 -0.46541502 -0.432175032 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids MicroRNAs in cancer 0 -0.473320158 0 kegg kegg NA NA no no no no no no Butanoate metabolism MicroRNAs in cancer 0 -0.764822134 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway MicroRNAs in cancer 0.503478261 0.855731225 0.472844273 kegg kegg NA NA no no no no no no cAMP signaling pathway MicroRNAs in cancer 0 0.529644269 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption MicroRNAs in cancer 0.466956522 0.736166008 0.74980695 kegg kegg NA NA no no no no no no Cardiac muscle contraction MicroRNAs in cancer 0 -0.600790514 0 kegg kegg NA NA no no up no no no Cell cycle MicroRNAs in cancer 0 0 0.528185328 kegg kegg NA NA no no no no no no Cellular senescence MicroRNAs in cancer 0 0.471343874 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway MicroRNAs in cancer 0 0.429841897 0 kegg kegg NA NA no no no no no no Chagas disease MicroRNAs in cancer 0 0.795454545 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway MicroRNAs in cancer 0 0.542490119 0 kegg kegg NA NA no no no no no no Cholinergic synapse MicroRNAs in cancer 0 0 0.593050193 kegg kegg NA NA no no no no no no Circadian entrainment MicroRNAs in cancer -0.423478261 -0.697628458 -0.479021879 kegg kegg NA NA no up up no no no Circadian rhythm MicroRNAs in cancer 0 0 0.666151866 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) MicroRNAs in cancer 0 -0.77173913 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion MicroRNAs in cancer 0 0 -0.517117117 kegg kegg NA NA no no no no no no Collinsella MicroRNAs in cancer -0.424717306 0 -0.507885269 Genus kegg 0.128 NA no no no no no no Complement and coagulation cascades MicroRNAs in cancer 0 0 -0.483655084 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 MicroRNAs in cancer 0 -0.623517787 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism MicroRNAs in cancer 0 -0.746047431 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction MicroRNAs in cancer 0 0 -0.453281853 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway MicroRNAs in cancer 0 0.606719368 0 kegg kegg NA NA no no no no no no DNA replication MicroRNAs in cancer 0 -0.675889328 0 kegg kegg NA NA no no no no no no Dopaminergic synapse MicroRNAs in cancer 0 -0.590909091 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 MicroRNAs in cancer 0 -0.808300395 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes MicroRNAs in cancer 0 -0.811264822 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance MicroRNAs in cancer 0 -0.536561265 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption MicroRNAs in cancer -0.408695652 -0.4743083 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection MicroRNAs in cancer 0 0.631422925 0 kegg kegg NA NA no no no no no no ErbB signaling pathway MicroRNAs in cancer 0.420869565 0.708498024 0.871557272 kegg kegg NA NA no no no no no no Estrogen signaling pathway MicroRNAs in cancer 0 -0.68972332 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis MicroRNAs in cancer 0 0.641304348 0 kegg kegg NA NA no no no no no no Fatty acid elongation MicroRNAs in cancer 0 -0.584980237 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway MicroRNAs in cancer 0 0.747035573 0 kegg kegg NA NA no no no no no no Ferroptosis MicroRNAs in cancer -0.464347826 0 -0.54028314 kegg kegg NA NA no no no no no no Focal adhesion MicroRNAs in cancer 0 -0.768774704 0 kegg kegg NA NA no up up no no no FoxO signaling pathway MicroRNAs in cancer 0.410434783 0.65513834 0.474388674 kegg kegg NA NA no no no no no no Fructose and mannose metabolism MicroRNAs in cancer 0 0.48715415 0 kegg kegg NA NA no no no no no no GABAergic synapse MicroRNAs in cancer 0 0.548418972 0 kegg kegg NA NA no up up no no no Galactose metabolism MicroRNAs in cancer 0 0.447628458 0 kegg kegg NA NA no no no no no no Gap junction MicroRNAs in cancer 0 0 -0.44967825 kegg kegg NA NA no no no no no no Gastric acid secretion MicroRNAs in cancer 0 -0.780632411 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway MicroRNAs in cancer 0 -0.549407115 0 kegg kegg NA NA no no no no no no Glutathione metabolism MicroRNAs in cancer -0.554782609 -0.556324111 -0.687773488 kegg kegg NA NA no no no no no no Glycerolipid metabolism MicroRNAs in cancer 0.495652174 0.511857708 0.492921493 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism MicroRNAs in cancer 0 0.435770751 0.564736165 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" MicroRNAs in cancer -0.406086957 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis MicroRNAs in cancer 0 -0.759881423 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate MicroRNAs in cancer 0 0.822134387 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series MicroRNAs in cancer 0 0.499011858 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism MicroRNAs in cancer 0 0.649209486 0 kegg kegg NA NA no no no no no no GnRH secretion MicroRNAs in cancer 0.414782609 0.735177866 0.779150579 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" MicroRNAs in cancer 0 0.51284585 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway MicroRNAs in cancer 0 0 0.749292149 kegg kegg NA NA no no no no no no Hematopoietic cell lineage MicroRNAs in cancer 0 -0.504940711 0 kegg kegg NA NA no no no no no no Hepatitis B MicroRNAs in cancer 0.528695652 0.927865613 0.646846847 kegg kegg NA NA no no no no no no Hepatitis C MicroRNAs in cancer 0.415652174 0.707509881 0.541055341 kegg kegg NA NA no no no no no no HIF-1 signaling pathway MicroRNAs in cancer 0 -0.603754941 0 kegg kegg NA NA no no no no no no Hippo signaling pathway MicroRNAs in cancer 0 -0.725296443 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species MicroRNAs in cancer 0 0.709486166 0 kegg kegg NA NA no no no no no no Human papillomavirus infection MicroRNAs in cancer 0 0.51284585 0 kegg kegg NA NA no no no no no no Huntington disease MicroRNAs in cancer 0 -0.627470356 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels MicroRNAs in cancer 0 -0.616600791 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism MicroRNAs in cancer 0.575652174 0 0.538481338 kegg kegg NA NA no no no no no no Insulin resistance MicroRNAs in cancer 0.516521739 0.91798419 0.655341055 kegg kegg NA NA no no no no no no Insulin signaling pathway MicroRNAs in cancer 0 -0.608695652 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway MicroRNAs in cancer 0.565217391 0.829051383 0.437065637 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection MicroRNAs in cancer 0 0 -0.464350064 kegg kegg NA NA no no dn no no no Lachnospira MicroRNAs in cancer 0 -0.557944173 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Leishmaniasis MicroRNAs in cancer 0 -0.470355731 0 kegg kegg NA NA no no no no no no Long-term potentiation MicroRNAs in cancer 0 -0.530632411 0.539253539 kegg kegg NA NA no no up no no no Lysine degradation MicroRNAs in cancer 0.422608696 0 0.61003861 kegg kegg NA NA no no no no no no Malaria MicroRNAs in cancer -0.63826087 0 -0.491377091 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis MicroRNAs in cancer 0 0 0.566795367 kegg kegg NA NA no no no no no no MAPK signaling pathway MicroRNAs in cancer 0.509565217 0 0.728442728 kegg kegg NA NA no no no no no no Measles MicroRNAs in cancer 0.417391304 0 0 kegg kegg NA NA no no no no no no Melanogenesis MicroRNAs in cancer 0 -0.580039526 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 MicroRNAs in cancer 0 -0.833003953 0 kegg kegg NA NA no no no no no no Mineral absorption MicroRNAs in cancer -0.463478261 0 -0.551866152 kegg kegg NA NA no no no no no no Mismatch repair MicroRNAs in cancer 0 -0.614624506 0 kegg kegg NA NA no no no no no no Mitophagy - animal MicroRNAs in cancer 0 0 -0.433204633 kegg kegg NA NA no no no no no no mRNA surveillance pathway MicroRNAs in cancer 0 0 0.595366795 kegg kegg NA NA no no no no no no mTOR signaling pathway MicroRNAs in cancer 0 -0.507905138 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis MicroRNAs in cancer 0 -0.603754941 0.401287001 kegg kegg NA NA no no no no no no Necroptosis MicroRNAs in cancer -0.454782609 0 -0.518661519 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway MicroRNAs in cancer 0 0.789525692 0.433204633 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation MicroRNAs in cancer 0 0 -0.435006435 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway MicroRNAs in cancer 0.485217391 0.931818182 0.470785071 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism MicroRNAs in cancer 0 0.662055336 0 kegg kegg NA NA no no no no no no Nitrogen metabolism MicroRNAs in cancer 0 0.641304348 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway MicroRNAs in cancer 0 0.796442688 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease MicroRNAs in cancer 0 -0.510869565 0 kegg kegg NA NA no no no no no no Non-homologous end-joining MicroRNAs in cancer 0 -0.659090909 0 kegg kegg NA NA no no no no no no Notch signaling pathway MicroRNAs in cancer 0 0.54743083 0.568082368 kegg kegg NA NA no no no no no no Nucleotide excision repair MicroRNAs in cancer 0 -0.580039526 0 kegg kegg NA NA no no no no no no One carbon pool by folate MicroRNAs in cancer 0 -0.600790514 0 kegg kegg NA NA no no no no no no Oocyte meiosis MicroRNAs in cancer 0 -0.665019763 0 kegg kegg NA NA no no no no no no Osteoclast differentiation MicroRNAs in cancer 0.42173913 0.656126482 0 kegg kegg NA NA no no no no no no Other glycan degradation MicroRNAs in cancer 0.424347826 0.503952569 0.450707851 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis MicroRNAs in cancer 0 0 0.643758044 kegg kegg NA NA no no no no no no Oxidative phosphorylation MicroRNAs in cancer 0 -0.622529644 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway MicroRNAs in cancer 0 -0.578063241 -0.565508366 kegg kegg NA NA no no no no no no p53 signaling pathway MicroRNAs in cancer 0 0 0.489060489 kegg kegg NA NA no no no no no no Pancreatic secretion MicroRNAs in cancer 0 -0.461462451 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis MicroRNAs in cancer 0 0.541501976 0 kegg kegg NA NA no no dn no no no Paraprevotella MicroRNAs in cancer -0.40680091 0 0 Genus kegg 0.118 NA no no no no no no Parkinson disease MicroRNAs in cancer 0 -0.550395257 -0.482368082 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection MicroRNAs in cancer 0 0 -0.451480051 kegg kegg NA NA no no no no no no Pathways in cancer MicroRNAs in cancer 0 0.786561265 0.545945946 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases MicroRNAs in cancer 0 -0.529644269 -0.491119691 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions MicroRNAs in cancer 0 -0.701581028 0 kegg kegg NA NA no no no no no no Peroxisome MicroRNAs in cancer 0 0.473320158 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism MicroRNAs in cancer 0 -0.750988142 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system MicroRNAs in cancer 0 0 0.695495495 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway MicroRNAs in cancer 0 0.723320158 0 kegg kegg NA NA no up up no no no Phototransduction MicroRNAs in cancer 0 -0.769762846 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway MicroRNAs in cancer 0.509565217 0 0 yes kegg kegg NA NA no up up no no no Platelet activation MicroRNAs in cancer 0 -0.685770751 -0.425997426 kegg kegg NA NA no no no no no no Platinum drug resistance MicroRNAs in cancer 0 0 0.520978121 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism MicroRNAs in cancer -0.487826087 0 -0.462290862 kegg kegg NA NA no no no no no no PPAR signaling pathway MicroRNAs in cancer 0 0.599802372 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis MicroRNAs in cancer 0 -0.630434783 0 kegg kegg NA NA no no no no no no Prion disease MicroRNAs in cancer 0 -0.681818182 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation MicroRNAs in cancer 0.473043478 0 0.705276705 kegg kegg NA NA no no no no no no Prolactin signaling pathway MicroRNAs in cancer 0 0.720355731 0.536164736 kegg kegg NA NA no no no no no no Propanoate metabolism MicroRNAs in cancer 0 -0.736166008 0 kegg kegg NA NA no no no no no no Proteasome MicroRNAs in cancer 0 -0.707509881 0 kegg kegg NA NA no no no no no no Protein digestion and absorption MicroRNAs in cancer 0 0.479249012 0.446846847 yes kegg kegg NA NA no up up no no no Protein export MicroRNAs in cancer 0 -0.624505929 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum MicroRNAs in cancer 0 -0.541501976 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer MicroRNAs in cancer 0 -0.585968379 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation MicroRNAs in cancer 0 -0.633399209 0 kegg kegg NA NA no no no no no no Purine metabolism MicroRNAs in cancer -0.430434783 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism MicroRNAs in cancer 0 -0.589920949 0 kegg kegg NA NA no no no no no no Pyruvate metabolism MicroRNAs in cancer 0 -0.781620553 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway MicroRNAs in cancer 0 -0.493083004 -0.422651223 kegg kegg NA NA no no no no no no Ras signaling pathway MicroRNAs in cancer 0 -0.585968379 0.429086229 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton MicroRNAs in cancer 0 -0.658102767 -0.46023166 kegg kegg NA NA no no no no no no Relaxin signaling pathway MicroRNAs in cancer 0 0.64229249 0 kegg kegg NA NA no no no no no no Renin secretion MicroRNAs in cancer -0.463478261 -0.725296443 0 kegg kegg NA NA no no no no no no Retinol metabolism MicroRNAs in cancer 0 -0.546442688 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling MicroRNAs in cancer 0 -0.679841897 0 kegg kegg NA NA no no up no no no Ribosome MicroRNAs in cancer 0 -0.635375494 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes MicroRNAs in cancer 0 0 0.446332046 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway MicroRNAs in cancer 0 0.93083004 0 kegg kegg NA NA no no no no no no RNA degradation MicroRNAs in cancer 0 -0.483201581 0.6 kegg kegg NA NA no no no no no no RNA polymerase MicroRNAs in cancer 0 -0.47826087 0 kegg kegg NA NA no no no no no no RNA transport MicroRNAs in cancer 0 -0.496047431 0 kegg kegg NA NA no no no no no no Ruminococcus MicroRNAs in cancer 0 -0.416048824 0 Genus kegg 0.0679 NA no no dn no no no Ruminococcus MicroRNAs in cancer -0.424347826 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Salivary secretion MicroRNAs in cancer 0 -0.484189723 0 kegg kegg NA NA no no no no no no Selenocompound metabolism MicroRNAs in cancer 0 0 0.461518662 kegg kegg NA NA no no no no no no Serotonergic synapse MicroRNAs in cancer 0 0 -0.43963964 kegg kegg NA NA no no no no no no Shigellosis MicroRNAs in cancer 0 0 -0.566537967 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells MicroRNAs in cancer 0 0.502964427 0.832947233 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport MicroRNAs in cancer 0.433043478 0.67687747 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway MicroRNAs in cancer 0 0.518774704 0.561904762 kegg kegg NA NA no no no no no no Spinocerebellar ataxia MicroRNAs in cancer 0 0 0.546203346 kegg kegg NA NA no no no no no no Spliceosome MicroRNAs in cancer 0 0 0.620849421 kegg kegg NA NA no no no no no no Staphylococcus aureus infection MicroRNAs in cancer 0 0 -0.411325611 kegg kegg NA NA up no no no no no Starch and sucrose metabolism MicroRNAs in cancer 0 0.535573123 0 kegg kegg NA NA no no no no no no Steroid biosynthesis MicroRNAs in cancer 0 -0.654150198 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis MicroRNAs in cancer 0 -0.639328063 0 kegg kegg NA NA no no no no no no Sulfur metabolism MicroRNAs in cancer 0 0 -0.497812098 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies MicroRNAs in cancer 0 -0.584980237 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway MicroRNAs in cancer 0.484347826 0.643280632 0.524581725 kegg kegg NA NA no no no no no no Taste transduction MicroRNAs in cancer 0 -0.493083004 0.51042471 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism MicroRNAs in cancer 0 0.644268775 0.54002574 kegg kegg NA NA no no no no no no TGF-beta signaling pathway MicroRNAs in cancer 0 -0.590909091 0 kegg kegg NA NA no no no no no no Th17 cell differentiation MicroRNAs in cancer 0 0.438735178 0 kegg kegg NA NA no no no no no no Thermogenesis MicroRNAs in cancer 0 -0.690711462 0 kegg kegg NA NA no no no no no no Thiamine metabolism MicroRNAs in cancer 0 -0.603754941 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway MicroRNAs in cancer 0 -0.565217391 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis MicroRNAs in cancer -0.442608696 0 -0.51042471 kegg kegg NA NA no no no no no no Tight junction MicroRNAs in cancer 0 -0.71541502 -0.658687259 kegg kegg NA NA no no no no no no TNF signaling pathway MicroRNAs in cancer 0 0.903162055 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway MicroRNAs in cancer 0.433043478 0.806324111 0 yes kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer MicroRNAs in cancer 0.454782609 0.915019763 0.619047619 kegg kegg NA NA no no no no no no Tryptophan metabolism MicroRNAs in cancer 0 -0.675889328 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus MicroRNAs in cancer 0.574782609 0.866600791 0.657142857 kegg kegg NA NA no no no no no no Tyrosine metabolism MicroRNAs in cancer 0 -0.778656126 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis MicroRNAs in cancer 0 -0.599802372 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis MicroRNAs in cancer 0 0 -0.455341055 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" MicroRNAs in cancer 0 -0.7243083 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis MicroRNAs in cancer 0 -0.459486166 0.444272844 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction MicroRNAs in cancer 0 -0.692687747 -0.416988417 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption MicroRNAs in cancer 0 -0.536561265 0 kegg kegg NA NA no no no no no no VEGF signaling pathway MicroRNAs in cancer 0.426086957 0.661067194 0.711711712 kegg kegg NA NA no no no no no no Vibrio cholerae infection MicroRNAs in cancer 0 -0.708498024 -0.499356499 kegg kegg NA NA no no no no no no Viral carcinogenesis MicroRNAs in cancer 0 0.548418972 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor MicroRNAs in cancer 0 0 -0.684942085 kegg kegg NA NA no no no no no no Wnt signaling pathway MicroRNAs in cancer 0 -0.507905138 0.606949807 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Mineral absorption 0 0 -0.425740026 kegg kegg NA NA no no no no no no ABC transporters Mineral absorption -0.552173913 0 0 kegg kegg NA NA no up up no no no Adipocytokine signaling pathway Mineral absorption 0.568695652 0 0.650965251 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Mineral absorption 0.60173913 0.59486166 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Mineral absorption 0 0 -0.477992278 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Mineral absorption 0.624347826 0.587944664 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Mineral absorption 0 0 -0.515830116 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Mineral absorption -0.419130435 -0.48715415 -0.469240669 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Mineral absorption -0.427826087 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Mineral absorption -0.489565217 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Mineral absorption 0.509565217 0.46541502 0.654568855 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Mineral absorption 0 0 0.503989704 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Mineral absorption 0 0 -0.435778636 kegg kegg NA NA no no no no no no Autophagy - animal Mineral absorption 0 0 -0.40952381 kegg kegg NA NA no no no no no no beta-Alanine metabolism Mineral absorption -0.457391304 -0.475296443 0 kegg kegg NA NA no no no no no no Bile secretion Mineral absorption 0.74173913 0.650197628 0.630888031 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Mineral absorption 0 0 0.549292149 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Mineral absorption -0.584347826 -0.571146245 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Mineral absorption 0.469565217 0.662055336 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Mineral absorption 0.433043478 0.457509881 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Mineral absorption 0 0 -0.588159588 kegg kegg NA NA no no no no no no Carbon metabolism Mineral absorption -0.416521739 -0.47826087 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Mineral absorption 0 0.60770751 0 kegg kegg NA NA no no up no no no Cholinergic synapse Mineral absorption 0 0 -0.512741313 kegg kegg NA NA no no no no no no Circadian entrainment Mineral absorption 0.552173913 0 0.534620335 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Mineral absorption -0.428695652 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Mineral absorption 0 -0.418972332 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Mineral absorption 0.691304348 0.669960474 0 kegg kegg NA NA no no up no no no Cushing syndrome Mineral absorption 0.572173913 0.579051383 0 kegg kegg NA NA no no up no no no Cytokine-cytokine receptor interaction Mineral absorption 0 -0.479249012 0 kegg kegg NA NA no no no no no no DNA replication Mineral absorption -0.42173913 0 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Mineral absorption 0.596521739 0.446640316 0 kegg kegg NA NA no up no no no no Endocrine and other factor-regulated calcium reabsorption Mineral absorption 0.673043478 0.662055336 0.509395109 kegg kegg NA NA no no no no no no Endocrine resistance Mineral absorption 0.500869565 0.464426877 0 kegg kegg NA NA no no no no no no Endocytosis Mineral absorption 0 -0.424901186 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Mineral absorption 0 0 -0.65045045 kegg kegg NA NA no no no no no no Fanconi anemia pathway Mineral absorption -0.470434783 0 0 kegg kegg NA NA no no no no no no Fatty acid degradation Mineral absorption -0.572173913 -0.596837945 0 kegg kegg NA NA no no no no no no Fatty acid elongation Mineral absorption -0.485217391 -0.533596838 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Mineral absorption -0.606956522 -0.641304348 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Mineral absorption -0.604347826 -0.557312253 0 kegg kegg NA NA no no no no no no Ferroptosis Mineral absorption 0.869565217 0.779644269 0.93976834 kegg kegg NA NA no no no no no no FoxO signaling pathway Mineral absorption 0 -0.506916996 0 kegg kegg NA NA no no no no no no Galactose metabolism Mineral absorption -0.553043478 -0.58201581 -0.425482625 kegg kegg NA NA no no no no no no Gap junction Mineral absorption 0.519130435 0.545454545 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Mineral absorption 0.5 0.480237154 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Mineral absorption 0.514782609 0 0.431145431 kegg kegg NA NA no up up no no no Glutathione metabolism Mineral absorption 0.484347826 0.464426877 0.621106821 kegg kegg NA NA no no no no no no Glycerolipid metabolism Mineral absorption -0.423478261 0 -0.61029601 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Mineral absorption 0 0 -0.483655084 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Mineral absorption 0 0 0.56010296 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Mineral absorption 0 0 -0.478249678 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Mineral absorption 0.448695652 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Mineral absorption 0 0 -0.539253539 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Mineral absorption -0.445217391 0 0 kegg kegg NA NA no no no no no no GnRH secretion Mineral absorption 0 0 -0.519433719 kegg kegg NA NA no up up no no no GnRH signaling pathway Mineral absorption 0.649565217 0.602766798 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Mineral absorption 0 0 -0.517117117 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Mineral absorption 0 -0.419960474 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Mineral absorption 0 0 -0.486743887 kegg kegg NA NA no no no no no no Histidine metabolism Mineral absorption -0.426956522 -0.416007905 0 kegg kegg NA NA no no no no no no Homologous recombination Mineral absorption -0.532173913 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Mineral absorption 0.570434783 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Mineral absorption -0.527826087 0 -0.561647362 kegg kegg NA NA no no no no no no Insulin secretion Mineral absorption 0.610434783 0.657114625 0 yes kegg kegg NA NA no up up no no no Long-term depression Mineral absorption 0.723478261 0.640316206 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Mineral absorption 0.6 0 0.638867439 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Mineral absorption -0.426086957 -0.690711462 0 kegg kegg NA NA no no no no no no Lysine degradation Mineral absorption 0 0 -0.470527671 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Mineral absorption 0 0 -0.4002574 kegg kegg NA NA no no no no no no MAPK signaling pathway Mineral absorption -0.449565217 -0.4743083 -0.585585586 kegg kegg NA NA no no no no no no Melanogenesis Mineral absorption 0.563478261 0.516798419 0 kegg kegg NA NA no no no no no no Mismatch repair Mineral absorption -0.496521739 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Mineral absorption 0.855652174 0.77173913 0.807979408 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Mineral absorption -0.447826087 -0.475296443 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Mineral absorption 0 0 -0.436550837 kegg kegg NA NA no no no no no no Necroptosis Mineral absorption 0.947826087 0.920948617 0.959330759 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Mineral absorption -0.435652174 -0.606719368 0 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Mineral absorption -0.584347826 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Mineral absorption -0.522608696 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Mineral absorption 0.464347826 0.659090909 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Mineral absorption -0.519130435 -0.43083004 0 kegg kegg NA NA no no no no no no Notch signaling pathway Mineral absorption 0 0 -0.527670528 kegg kegg NA NA no no no no no no Nucleotide excision repair Mineral absorption -0.434782609 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Mineral absorption -0.433913043 -0.416007905 0 kegg kegg NA NA no no no no no no Other glycan degradation Mineral absorption -0.408695652 0 -0.689317889 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Mineral absorption 0 0 -0.51016731 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Mineral absorption 0.564347826 0.673913043 0.531274131 kegg kegg NA NA no up up no no no Oxidative phosphorylation Mineral absorption 0.406956522 0.588932806 0 kegg kegg NA NA no no no no no no Pancreatic secretion Mineral absorption 0.679130435 0.610671937 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Mineral absorption -0.426956522 -0.495059289 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Mineral absorption 0.623478261 0.745059289 0.534362934 kegg kegg NA NA no no no no no no Peroxisome Mineral absorption -0.469565217 -0.498023715 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Mineral absorption 0 0 -0.491634492 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Mineral absorption 0.457391304 0 0.61981982 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Mineral absorption -0.543478261 -0.424901186 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Mineral absorption 0 0 -0.581467181 kegg kegg NA NA no no no no no no Protein digestion and absorption Mineral absorption -0.477391304 -0.648221344 -0.439124839 yes kegg kegg NA NA no up up no no no Protein processing in endoplasmic reticulum Mineral absorption 0 0 0.508622909 kegg kegg NA NA no no no no no no Purine metabolism Mineral absorption 0.453913043 0 0.746460746 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Mineral absorption 0.691304348 0.654150198 0.444530245 kegg kegg NA NA no no no no no no Relaxin signaling pathway Mineral absorption 0.484347826 0.455533597 0 kegg kegg NA NA no no no no no no Renin secretion Mineral absorption 0.565217391 0 0.534620335 kegg kegg NA NA no no no no no no Renin-angiotensin system Mineral absorption 0 -0.445652174 0 kegg kegg NA NA no no no no no no Retinol metabolism Mineral absorption -0.462608696 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Mineral absorption 0 0.494071146 0 kegg kegg NA NA no no up no no no Ribosome Mineral absorption 0.586086957 0.523715415 0 kegg kegg NA NA no no no no no no RNA degradation Mineral absorption 0 0 -0.434234234 kegg kegg NA NA no no no no no no Salivary secretion Mineral absorption 0.447826087 0 0.438352638 kegg kegg NA NA no no no no no no Selenocompound metabolism Mineral absorption 0 0 -0.458944659 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Mineral absorption 0 0 -0.502187902 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Mineral absorption -0.473913043 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Mineral absorption 0 0 -0.553410553 kegg kegg NA NA no no no no no no Spliceosome Mineral absorption 0 0 -0.403603604 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Mineral absorption -0.414782609 -0.447628458 0 kegg kegg NA NA no no no no no no Sulfur metabolism Mineral absorption 0 0 0.449163449 kegg kegg NA NA no no no no no no Taste transduction Mineral absorption 0 0 -0.56962677 kegg kegg NA NA no no up no no no Terpenoid backbone biosynthesis Mineral absorption 0 -0.428853755 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Mineral absorption 0 0 -0.472586873 kegg kegg NA NA no no no no no no Th17 cell differentiation Mineral absorption 0 0 -0.476705277 kegg kegg NA NA no no no no no no Thermogenesis Mineral absorption 0.482608696 0.550395257 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Mineral absorption 0.613913043 0.731225296 0.648906049 kegg kegg NA NA no no no no no no Tryptophan metabolism Mineral absorption -0.445217391 -0.500988142 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Mineral absorption 0 0 -0.499356499 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Mineral absorption -0.423478261 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Mineral absorption 0.780869565 0.716403162 0.7997426 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Mineral absorption -0.455652174 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Mineral absorption 0 0 -0.578120978 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Mineral absorption 0.719130435 0.470355731 0.566537967 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Mineral absorption 0.646956522 0.643280632 0.522265122 kegg kegg NA NA no no no no no no VEGF signaling pathway Mineral absorption 0 0 -0.538223938 kegg kegg NA NA no no no no no no Wnt signaling pathway Mineral absorption 0 0 -0.457400257 kegg kegg NA NA no no no no no no IFN-g MIP-1a 0 -0.479220779 0 serum_cytokines serum_cytokines 0.825 0.68 no no no no no no IL-2 MIP-1a 0 0 -0.634260289 serum_cytokines serum_cytokines 0.522 0.68 no no no no no no IL-6 MIP-1a 0 0 -0.542602892 serum_cytokines serum_cytokines 0.52 0.68 no no no no no no IL-8 MIP-1a 0 0 -0.42647386 serum_cytokines serum_cytokines 0.579 0.68 no no no no no no IP-10 MIP-1a 0 0.574025974 0 serum_cytokines serum_cytokines 0.394 0.68 no no no no no no 12-ketoDCA+blood MIP-1b 0 0.679066556 0 serum_bileacids serum_cytokines 0.517 0.632 no no no no no no 14:0/16:0-PC+blood MIP-1b 0 0 0.445112782 serum_phospholipids serum_cytokines 0.0358 0.632 no up no no no no 14:0/20:4-PC+blood MIP-1b 0 0 0.484210526 serum_phospholipids serum_cytokines 0.486 0.632 no no no no no no 16:0/16:1-PC+blood MIP-1b 0 0 0.514285714 serum_phospholipids serum_cytokines 0.00283 0.632 up up no no no no 16:0/18:3-PC+blood MIP-1b 0 0 0.708270677 serum_phospholipids serum_cytokines 0.00216 0.632 no up up no no no 16:0/22:6-PE+blood MIP-1b 0.709090909 0 0 serum_phospholipids serum_cytokines 0.000934 0.632 up up no no no no 18:1/18:1-PE+blood MIP-1b 0.939393939 0 0 serum_phospholipids serum_cytokines 1.03E-05 0.632 up up no no no no 20:2+blood MIP-1b 0 0 -0.494736842 serum_fattyacid serum_cytokines 0.478 0.632 no no no no no no 20:4/18:0-PE+blood MIP-1b 0.757575758 0 0 serum_phospholipids serum_cytokines 0.000755 0.632 up up no no no no 9-HODE+blood MIP-1b 0 0 0.463157895 serum_ARA serum_cytokines 0.297 0.632 no no no no no no Adrenergic signaling in cardiomyocytes MIP-1b -0.741758242 0 0.490968801 kegg serum_cytokines NA 0.632 no no up no no no Akkermansia MIP-1b 0 0 -0.401073732 acetate-producing Genus serum_cytokines 0.23 0.632 no no no no no no Alcoholism MIP-1b -0.554945055 -0.472180451 0 kegg serum_cytokines NA 0.632 no no no no no no Aldosterone synthesis and secretion MIP-1b -0.620879121 0 0.447181171 kegg serum_cytokines NA 0.632 no up up no no no Amphetamine addiction MIP-1b 0 0 0.417624521 kegg serum_cytokines NA 0.632 no no no no no no Antigen processing and presentation MIP-1b 0 -0.568421053 0 kegg serum_cytokines NA 0.632 no no no no no no Apoptosis MIP-1b 0 0 -0.585659551 kegg serum_cytokines NA 0.632 no no no no no no Betaine+blood MIP-1b -0.636363636 0 0 serum_choline serum_cytokines 0.857 0.632 no no no no no no Biosynthesis of amino acids MIP-1b 0 -0.445112782 -0.506294472 kegg serum_cytokines NA 0.632 no no no no no no Blautia MIP-1b 0 -0.449350649 0 acetate-producing Genus serum_cytokines 1.36E-05 0.632 up dn dn no no no CA+blood MIP-1b 0 0 0.496983959 serum_bileacids serum_cytokines 0.606 0.632 no no no no no no Calcium signaling pathway MIP-1b -0.604395604 0 0 kegg serum_cytokines NA 0.632 no up up no no no Carbon metabolism MIP-1b 0 -0.535338346 -0.556102901 kegg serum_cytokines NA 0.632 no no no no no no Cell cycle MIP-1b 0 0 0.469074986 kegg serum_cytokines NA 0.632 no no no no no no Chemical carcinogenesis - receptor activation MIP-1b 0 0.490225564 0 kegg serum_cytokines NA 0.632 no no no no no no Choline metabolism in cancer MIP-1b 0 0.461654135 0 kegg serum_cytokines NA 0.632 no no no no no no Chronic myeloid leukemia MIP-1b 0 0.454135338 0 kegg serum_cytokines NA 0.632 no no no no no no Clostridium MIP-1b 0.574594405 -0.595809451 0 Genus serum_cytokines 0.925 0.632 no no no no no no Colorectal cancer MIP-1b 0 0.467669173 0 kegg serum_cytokines NA 0.632 no no no no no no Cushing syndrome MIP-1b 0 0.479699248 0.435686918 kegg serum_cytokines NA 0.632 no no up no no no Cysteine+blood MIP-1b -0.660606061 0 -0.606015038 yes serum_aminoacids serum_cytokines 1.81E-07 0.632 dn up up no no no d18:1-20:0-SM+blood MIP-1b 0.721212121 0 0 serum_phospholipids serum_cytokines 0.933 0.632 no no no no no no DCA+stool MIP-1b 0 0.769230769 0 stool_bileacids serum_cytokines 0.195 0.632 no no no no no no Dopaminergic synapse MIP-1b 0 0 0.455391352 kegg serum_cytokines NA 0.632 no up no no no no Eotaxin MIP-1b 0 0.476623377 0.498998888 serum_cytokines serum_cytokines 0.393 0.632 no no no no no no Epstein-Barr virus infection MIP-1b 0 -0.530827068 0 kegg serum_cytokines NA 0.632 no no no no no no ErbB signaling pathway MIP-1b 0 0.526315789 0 kegg serum_cytokines NA 0.632 no no no no no no Faecalibacterium MIP-1b -0.582417582 0 0 butyrate-producing Genus serum_cytokines 0.0039 0.632 no dn dn no no no Fc gamma R-mediated phagocytosis MIP-1b 0 0 -0.477285167 kegg serum_cytokines NA 0.632 no no no no no no Ferroptosis MIP-1b -0.571428571 0 0 kegg serum_cytokines NA 0.632 no no no no no no Fluid shear stress and atherosclerosis MIP-1b 0 -0.476691729 -0.522714833 kegg serum_cytokines NA 0.632 no no no no no no Gastric cancer MIP-1b 0 0.687218045 0 kegg serum_cytokines NA 0.632 no no no no no no GCA+stool MIP-1b 0 -0.769230769 0.517156863 stool_bileacids serum_cytokines 0.0809 0.632 no no no no no no GCDCA+stool MIP-1b 0 0 0.598039216 yes stool_bileacids serum_cytokines 0.0471 0.632 no dn no no no no GDCA+blood MIP-1b 0 0 -0.539849624 serum_bileacids serum_cytokines 0.632 0.632 no no no no no no GDCA+stool MIP-1b 0 0 0.484030945 stool_bileacids serum_cytokines 0.656 0.632 no no no no no no GLCA+blood MIP-1b 0 0.537276633 0 serum_bileacids serum_cytokines 0.319 0.632 no no no no no no Glucagon signaling pathway MIP-1b -0.554945055 0 0.549534756 kegg serum_cytokines NA 0.632 no no no no no no Glutamatergic synapse MIP-1b -0.56043956 0 0 kegg serum_cytokines NA 0.632 no up up no no no GM-CSF MIP-1b 0 -0.445454545 -0.647608454 yes serum_cytokines serum_cytokines 0.0124 0.632 up no no no no no HDCA+blood MIP-1b 0 0 -0.445082418 serum_bileacids serum_cytokines 0.483 0.632 no no no no no no Herpes simplex virus 1 infection MIP-1b 0 -0.467669173 0 kegg serum_cytokines NA 0.632 no no no no no no Homovanillic acid+urine MIP-1b 0 -0.597058824 0 urine_cometabolism serum_cytokines 0.45 0.632 no no no no no no Human cytomegalovirus infection MIP-1b 0 -0.47518797 0 kegg serum_cytokines NA 0.632 no no dn no no no Human immunodeficiency virus 1 infection MIP-1b 0 -0.506766917 0 kegg serum_cytokines NA 0.632 no no no no no no Human T-cell leukemia virus 1 infection MIP-1b 0 -0.518796992 0 kegg serum_cytokines NA 0.632 no no no no no no IFN-g MIP-1b 0 -0.712987013 -0.409121246 serum_cytokines serum_cytokines 0.825 0.632 no no no no no no IL-17 signaling pathway MIP-1b 0 0 -0.534209086 kegg serum_cytokines NA 0.632 no no no no no no IL-1b MIP-1b 0 0 -0.441156841 yes serum_cytokines serum_cytokines 0.00358 0.632 up up no no no no IL-2 MIP-1b -0.813186813 -0.680519481 -0.560845384 serum_cytokines serum_cytokines 0.522 0.632 no no no no no no IL-6 MIP-1b 0 -0.687012987 0 serum_cytokines serum_cytokines 0.52 0.632 no no no no no no IL-8 MIP-1b -0.60989011 -0.577922078 -0.63025584 serum_cytokines serum_cytokines 0.579 0.632 no no no no no no IL-9 MIP-1b 0.774725275 0.94025974 0.778865406 serum_cytokines serum_cytokines 0.906 0.632 no no no no no no Inflammatory mediator regulation of TRP channels MIP-1b 0 0 0.45210728 kegg serum_cytokines NA 0.632 no no no no no no Influenza A MIP-1b 0 0 -0.488232074 kegg serum_cytokines NA 0.632 no no no no no no IP-10 MIP-1b 0 0.453246753 0 serum_cytokines serum_cytokines 0.394 0.632 no no no no no no iso-LCA+blood MIP-1b 0 0.557068665 0 serum_bileacids serum_cytokines 0.507 0.632 no no no no no no iso-LCA+stool MIP-1b 0 0.832167832 0 stool_bileacids serum_cytokines 0.72 0.632 no no no no no no L-Arginine+blood MIP-1b -0.818181818 0 0 serum_aminoacids serum_cytokines 0.316 0.632 no no no no no no L-Methionine+blood MIP-1b -0.866666667 0 0 serum_aminoacids serum_cytokines 0.626 0.632 no no no no no no L-Phenylalanine+blood MIP-1b -0.842424242 0 0 yes serum_aminoacids serum_cytokines 0.0103 0.632 up up no no no no L-Phenylalanine+stool MIP-1b 0.781818182 0 0 stool_cometabolism serum_cytokines 0.398 0.632 no no no no no no L-Tryptophan+blood MIP-1b -0.696969697 0 0 serum_aminoacids serum_cytokines 0.164 0.632 no no no no no no L-Tryptophan+stool MIP-1b 0.721212121 0 0 stool_cometabolism serum_cytokines 0.557 0.632 no no no no no no L-Tyrosine+blood MIP-1b -0.781818182 0 0 yes serum_aminoacids serum_cytokines 0.00913 0.632 up up no no no no L-Tyrosine+stool MIP-1b 0.672727273 0 0 stool_cometabolism serum_cytokines 0.44 0.632 no no no no no no LCA+stool MIP-1b 0 0.797202797 0 stool_bileacids serum_cytokines 0.314 0.632 no no no no no no Leukocyte transendothelial migration MIP-1b 0 -0.530827068 -0.419813903 kegg serum_cytokines NA 0.632 no no no no no no Lipid and atherosclerosis MIP-1b 0 0 -0.455391352 kegg serum_cytokines NA 0.632 no no no no no no Longevity regulating pathway MIP-1b -0.686813187 0 0 kegg serum_cytokines NA 0.632 no no no no no no Longevity regulating pathway - multiple species MIP-1b 0 -0.445112782 0 kegg serum_cytokines NA 0.632 no no no no no no Lysosome MIP-1b 0 -0.494736842 -0.573070608 kegg serum_cytokines NA 0.632 no no no no no no Malaria MIP-1b -0.554945055 0 0 kegg serum_cytokines NA 0.632 no no no no no no Mineral absorption MIP-1b -0.604395604 0 0 kegg serum_cytokines NA 0.632 no no no no no no mRNA surveillance pathway MIP-1b 0 0 0.441160372 kegg serum_cytokines NA 0.632 no no no no no no MUFA%+blood MIP-1b 0 0 -0.553383459 serum_fattyacid serum_cytokines 0.00142 0.632 up no dn no no no Necroptosis MIP-1b -0.642857143 0 0 kegg serum_cytokines NA 0.632 no no no no no no Neuroactive ligand-receptor interaction MIP-1b 0 -0.457142857 -0.574165298 kegg serum_cytokines NA 0.632 up up up no no no Neutrophil extracellular trap formation MIP-1b 0 0 -0.568144499 kegg serum_cytokines NA 0.632 no no no no no no Non-small cell lung cancer MIP-1b 0 0.618045113 0 kegg serum_cytokines NA 0.632 no no no no no no Osteoclast differentiation MIP-1b 0 0 -0.427476738 kegg serum_cytokines NA 0.632 no no no no no no p53 signaling pathway MIP-1b 0 0.630075188 0 kegg serum_cytokines NA 0.632 no no no no no no Pathogenic Escherichia coli infection MIP-1b 0 0 -0.541324576 kegg serum_cytokines NA 0.632 no no no no no no Pathways in cancer MIP-1b 0 0.494736842 0 kegg serum_cytokines NA 0.632 no no no no no no Pertussis MIP-1b 0 0 -0.457580733 kegg serum_cytokines NA 0.632 no no dn no no no Phagosome MIP-1b 0 0 -0.420908593 kegg serum_cytokines NA 0.632 no no no no no no Platinum drug resistance MIP-1b 0 0.533834586 0 kegg serum_cytokines NA 0.632 no no no no no no Progesterone-mediated oocyte maturation MIP-1b 0 0.47518797 0 kegg serum_cytokines NA 0.632 no no no no no no Ras signaling pathway MIP-1b 0 0 0.521072797 yes kegg serum_cytokines NA 0.632 no up up no no no Regulation of actin cytoskeleton MIP-1b 0 -0.6 0 kegg serum_cytokines NA 0.632 no no no no no no Renal cell carcinoma MIP-1b 0 0 0.45922277 kegg serum_cytokines NA 0.632 no no no no no no Ruminococcus MIP-1b 0.56043956 0 0 Genus serum_cytokines 0.0679 0.632 no no dn no no no Salmonella infection MIP-1b 0 0 -0.469074986 kegg serum_cytokines NA 0.632 no no no no no no Signaling pathways regulating pluripotency of stem cells MIP-1b 0 0.532330827 0 kegg serum_cytokines NA 0.632 no no no no no no Spinocerebellar ataxia MIP-1b 0 0.448120301 0 kegg serum_cytokines NA 0.632 no no no no no no Spliceosome MIP-1b 0 0.581954887 0 kegg serum_cytokines NA 0.632 no no no no no no Staphylococcus aureus infection MIP-1b 0 0 -0.625068418 kegg serum_cytokines NA 0.632 up no no no no no Systemic lupus erythematosus MIP-1b 0 0 -0.537493158 kegg serum_cytokines NA 0.632 no no no no no no T cell receptor signaling pathway MIP-1b 0 0.485714286 0 kegg serum_cytokines NA 0.632 no no no no no no Taurine+blood MIP-1b 0 0 -0.476691729 serum_aminoacids serum_cytokines 0.857 0.632 no no no no no no TDCA+stool MIP-1b 0 -0.811516378 0 stool_bileacids serum_cytokines 0.963 0.632 no no no no no no TMAO+blood MIP-1b -0.648484848 0 -0.506766917 serum_choline serum_cytokines 0.00706 0.632 up up no no no no Tuberculosis MIP-1b 0 0 -0.63546798 kegg serum_cytokines NA 0.632 no no dn no no no Yersinia infection MIP-1b 0 0 -0.464148878 kegg serum_cytokines NA 0.632 no no no no no no 2-Oxocarboxylic acid metabolism Mismatch repair 0.525217391 0.564229249 0 kegg kegg NA NA no no no no no no ABC transporters Mismatch repair 0.495652174 0 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" Mismatch repair 0 -0.433794466 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Mismatch repair 0.602608696 0.423913043 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Mismatch repair 0.653913043 0.67687747 0.501930502 kegg kegg NA NA no no no no no no Antifolate resistance Mismatch repair 0.480869565 0.520750988 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Mismatch repair 0 -0.508893281 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Mismatch repair 0 -0.468379447 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Mismatch repair 0.573043478 0 0.420592021 kegg kegg NA NA no no no no no no Basal transcription factors Mismatch repair 0.419130435 0.639328063 0.6 kegg kegg NA NA no no no no no no Base excision repair Mismatch repair 0.58 0.681818182 0.748519949 kegg kegg NA NA no no no no no no beta-Alanine metabolism Mismatch repair 0.55826087 0.602766798 0.478507079 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Mismatch repair 0 0.690711462 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Mismatch repair 0.828695652 0.674901186 0.581467181 kegg kegg NA NA no no no no no no Butanoate metabolism Mismatch repair 0.674782609 0.804347826 0.699099099 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Mismatch repair 0.764347826 0.826086957 0.636293436 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Mismatch repair 0.783478261 0.83201581 0.732046332 kegg kegg NA NA no no no no no no DNA replication Mismatch repair 0.836521739 0.882411067 0.786872587 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Mismatch repair 0.467826087 0.782608696 0.42985843 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Mismatch repair 0.496521739 0.604743083 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Mismatch repair 0 0.433794466 0.493436293 kegg kegg NA NA no no no no no no Ether lipid metabolism Mismatch repair 0 0.443675889 0.434491634 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Mismatch repair 0 -0.460474308 0 kegg kegg NA NA no no no no no no Fatty acid elongation Mismatch repair 0.64 0.550395257 0.661003861 kegg kegg NA NA no no no no no no Fatty acid metabolism Mismatch repair 0.415652174 0 0 kegg kegg NA NA no no no no no no Folate biosynthesis Mismatch repair 0.412173913 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Mismatch repair 0 0.503952569 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Mismatch repair 0 0.444664032 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Mismatch repair 0.594782609 0.577075099 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Mismatch repair -0.512173913 -0.67687747 -0.436036036 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Mismatch repair -0.457391304 -0.43083004 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Mismatch repair 0 0.549407115 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Mismatch repair -0.47826087 -0.536561265 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Mismatch repair 0 -0.472332016 0 kegg kegg NA NA no no no no no no Histidine metabolism Mismatch repair 0.539130435 0 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Mismatch repair 0 0.454545455 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Mismatch repair -0.422608696 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Mismatch repair 0.464347826 0.748023715 0.442471042 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Mismatch repair 0.672173913 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Mismatch repair 0 0.605731225 0.400772201 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Mismatch repair 0 -0.549407115 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Mismatch repair 0 -0.467391304 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Mismatch repair 0.876521739 0.941699605 0.857400257 kegg kegg NA NA no no no no no no One carbon pool by folate Mismatch repair 0.789565217 0.831027668 0.543371943 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Mismatch repair 0.792173913 0.741106719 0.529472329 kegg kegg NA NA no no no no no no Pentose phosphate pathway Mismatch repair 0 -0.511857708 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Mismatch repair 0.466956522 0.721343874 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Mismatch repair 0 -0.612648221 -0.483912484 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Mismatch repair 0.92173913 0.666007905 0.405405405 kegg kegg NA NA no no no no no no Propanoate metabolism Mismatch repair 0.765217391 0.803359684 0.716859717 kegg kegg NA NA no no no no no no Proteasome Mismatch repair 0 0.551383399 0 kegg kegg NA NA no no no no no no Protein export Mismatch repair 0 0.493083004 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Mismatch repair 0.573043478 0.772727273 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Mismatch repair 0.850434783 0.815217391 0.684942085 kegg kegg NA NA no no no no no no Retinol metabolism Mismatch repair 0.777391304 0.826086957 0.686743887 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Mismatch repair 0.473043478 0.738142292 0.558558559 kegg kegg NA NA no no no no no no RNA degradation Mismatch repair 0 0.483201581 0 kegg kegg NA NA no no no no no no RNA polymerase Mismatch repair 0 0.710474308 0.597168597 kegg kegg NA NA no no no no no no RNA transport Mismatch repair 0.537391304 0.421936759 0.402574003 kegg kegg NA NA no no no no no no Selenocompound metabolism Mismatch repair 0 0.453557312 0.511711712 kegg kegg NA NA no no no no no no Sphingolipid metabolism Mismatch repair -0.531304348 0 0 kegg kegg NA NA no no no no no no Spliceosome Mismatch repair 0.411304348 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Mismatch repair 0 0.817193676 0.56036036 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Mismatch repair 0.67826087 0.761857708 0 kegg kegg NA NA no no no no no no Sulfur metabolism Mismatch repair 0 0.444664032 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Mismatch repair 0.811304348 0.873517787 0.725611326 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Mismatch repair 0.55826087 0.649209486 0.473101673 kegg kegg NA NA no no no no no no Thiamine metabolism Mismatch repair 0.552173913 0.650197628 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Mismatch repair 0.766086957 0.73715415 0.552380952 kegg kegg NA NA no up no no no no Tyrosine metabolism Mismatch repair 0.760869565 0.878458498 0.711711712 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Mismatch repair 0.812173913 0.882411067 0.714285714 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Mismatch repair 0.837391304 0.812252964 0.740540541 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Mismatch repair 0 0.505928854 0.403088803 kegg kegg NA NA no no no no no no ABC transporters Mitophagy - animal -0.486086957 0 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" Mitophagy - animal -0.453913043 0 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Mitophagy - animal -0.445217391 -0.601778656 -0.474388674 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Mitophagy - animal -0.44173913 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Mitophagy - animal -0.450434783 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Mitophagy - animal 0 0 0.411840412 kegg kegg NA NA no no no no no no Arginine and proline metabolism Mitophagy - animal 0 -0.528656126 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Mitophagy - animal -0.482608696 0 0 kegg kegg NA NA no no no no no no Bacteroides Mitophagy - animal -0.435652174 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no beta-Alanine metabolism Mitophagy - animal -0.553913043 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Mitophagy - animal -0.542608696 -0.532608696 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Mitophagy - animal 0 0.483201581 0.561904762 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Mitophagy - animal -0.623478261 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Mitophagy - animal 0.533913043 0.668972332 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Mitophagy - animal 0.565217391 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Mitophagy - animal -0.477391304 0 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Mitophagy - animal 0 -0.54743083 -0.417503218 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Mitophagy - animal 0 -0.451581028 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Mitophagy - animal 0.462608696 0.571146245 0 kegg kegg NA NA no no no no no no Endocrine resistance Mitophagy - animal 0.448695652 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Mitophagy - animal 0 0 -0.557786358 kegg kegg NA NA no no no no no no Ether lipid metabolism Mitophagy - animal 0.593043478 0 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Mitophagy - animal -0.537391304 -0.524703557 0 kegg kegg NA NA no no no no no no Fatty acid degradation Mitophagy - animal -0.764347826 -0.632411067 0 kegg kegg NA NA no no no no no no Fatty acid elongation Mitophagy - animal -0.58 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Mitophagy - animal -0.805217391 -0.675889328 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Mitophagy - animal -0.479130435 -0.597826087 0 kegg kegg NA NA no no no no no no Galactose metabolism Mitophagy - animal -0.603478261 -0.705533597 0 kegg kegg NA NA no no no no no no Glutathione metabolism Mitophagy - animal 0.46 0.666007905 0.6 kegg kegg NA NA no no no no no no Glycerolipid metabolism Mitophagy - animal 0 -0.504940711 -0.457915058 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Mitophagy - animal 0 0.600790514 0.563963964 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Mitophagy - animal -0.445217391 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Mitophagy - animal 0 -0.493083004 -0.446074646 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Mitophagy - animal 0 0 -0.455855856 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Mitophagy - animal 0.473913043 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Mitophagy - animal 0 -0.56027668 -0.589189189 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Mitophagy - animal -0.562608696 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Mitophagy - animal 0 0.497035573 0 kegg kegg NA NA no no no no no no Histidine metabolism Mitophagy - animal -0.473913043 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Mitophagy - animal -0.464347826 0 -0.465122265 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Mitophagy - animal 0.425217391 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Mitophagy - animal -0.450434783 -0.523715415 -0.471814672 kegg kegg NA NA no no no no no no Mismatch repair Mitophagy - animal -0.437391304 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Mitophagy - animal 0.5 0.493083004 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Mitophagy - animal -0.494782609 -0.611660079 0 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Mitophagy - animal -0.489565217 0 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Mitophagy - animal -0.507826087 -0.53458498 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Mitophagy - animal -0.582608696 0 0 kegg kegg NA NA no no no no no no Other glycan degradation Mitophagy - animal 0 -0.472332016 -0.601287001 kegg kegg NA NA no no no no no no Oxidative phosphorylation Mitophagy - animal 0.490434783 0.798418972 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Mitophagy - animal -0.66173913 -0.653162055 0 kegg kegg NA NA no no dn no no no Pentose phosphate pathway Mitophagy - animal 0 -0.587944664 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Mitophagy - animal 0 0.658102767 0.647876448 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Mitophagy - animal -0.490434783 0 0 kegg kegg NA NA no no no no no no Protein export Mitophagy - animal 0 0.477272727 0 kegg kegg NA NA no no no no no no Purine metabolism Mitophagy - animal 0.444347826 0.641304348 0.807722008 kegg kegg NA NA no no no no no no Pyrimidine metabolism Mitophagy - animal -0.499130435 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Mitophagy - animal 0 0 0.404633205 kegg kegg NA NA no no no no no no Retinol metabolism Mitophagy - animal -0.566086957 0 0 kegg kegg NA NA no no no no no no Ribosome Mitophagy - animal 0.770434783 0.754940711 0.537194337 kegg kegg NA NA no no no no no no RNA degradation Mitophagy - animal 0.48173913 0.415019763 0 kegg kegg NA NA no no no no no no RNA polymerase Mitophagy - animal 0 0.43972332 0 kegg kegg NA NA no no no no no no RNA transport Mitophagy - animal 0 0.462450593 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Mitophagy - animal 0 -0.583992095 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Mitophagy - animal 0 0 -0.527670528 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Mitophagy - animal 0 0 -0.68957529 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Mitophagy - animal -0.52 -0.638339921 0 kegg kegg NA NA no no no no no no Sulfur metabolism Mitophagy - animal 0 0 0.526898327 kegg kegg NA NA no no no no no no Tryptophan metabolism Mitophagy - animal -0.477391304 0 0 kegg kegg NA NA no up no no no no Ubiquitin mediated proteolysis Mitophagy - animal 0.967826087 0.975296443 0.993307593 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Mitophagy - animal 0 0 -0.418532819 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Morphine addiction -0.413913043 0 -0.552380952 kegg kegg NA NA no no no no up up ABC transporters Morphine addiction -0.669565217 0 0 kegg kegg NA NA no up up no up up Adherens junction Morphine addiction 0 0.447628458 0 kegg kegg NA NA no no no no up up Adrenergic signaling in cardiomyocytes Morphine addiction 0.74 0.654150198 0.63989704 kegg kegg NA NA no no up no up up "Alanine, aspartate and glutamate metabolism" Morphine addiction -0.467826087 -0.485177866 0 kegg kegg NA NA no no no no up up Aldosterone synthesis and secretion Morphine addiction 0.859130435 0.781620553 0.776833977 kegg kegg NA NA no up up no up up alpha-Linolenic acid metabolism Morphine addiction -0.64 0 -0.618018018 kegg kegg NA NA no no no no up up Alzheimer disease Morphine addiction 0.496521739 0.59486166 0 kegg kegg NA NA no no no no up up Amino sugar and nucleotide sugar metabolism Morphine addiction -0.477391304 0 -0.487773488 kegg kegg NA NA no no no no up up Aminoacyl-tRNA biosynthesis Morphine addiction -0.595652174 0 0 kegg kegg NA NA no no no no up up Amphetamine addiction Morphine addiction 0.640869565 0.638339921 0.757528958 kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis Morphine addiction 0.549565217 0.581027668 0 kegg kegg NA NA no no no no up up Apoptosis Morphine addiction 0 -0.41798419 0 kegg kegg NA NA no no no no up up Arachidonic acid metabolism Morphine addiction 0 0.528656126 0 kegg kegg NA NA no no no no up up Arginine and proline metabolism Morphine addiction -0.506956522 -0.416996047 0 kegg kegg NA NA no up no no up up Arginine biosynthesis Morphine addiction -0.439130435 -0.445652174 0 kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism Morphine addiction 0 0 -0.62007722 kegg kegg NA NA no no no no up up Autophagy - animal Morphine addiction 0 -0.459486166 -0.487516088 kegg kegg NA NA no no no no up up B cell receptor signaling pathway Morphine addiction 0 -0.416996047 0 kegg kegg NA NA no no no no up up Base excision repair Morphine addiction -0.434782609 0 0 kegg kegg NA NA no no no no up up beta-Alanine metabolism Morphine addiction -0.499130435 0 -0.520978121 kegg kegg NA NA no no no no up up Bile secretion Morphine addiction 0.893043478 0.890316206 0.808751609 kegg kegg NA NA no no no no up up Biosynthesis of amino acids Morphine addiction -0.409565217 -0.603754941 0 kegg kegg NA NA no no no no up up Biosynthesis of unsaturated fatty acids Morphine addiction -0.466956522 0 0 kegg kegg NA NA no no no no up up Butanoate metabolism Morphine addiction -0.440869565 0 0 kegg kegg NA NA no no no no up up Butyricimonas Morphine addiction 0.42062225 0 0 butyrate-producing Genus kegg 0.17 NA no no no no up up C-type lectin receptor signaling pathway Morphine addiction 0 -0.518774704 0 kegg kegg NA NA no no no no up up Calcium signaling pathway Morphine addiction 0.7 0.774703557 0.613384813 kegg kegg NA NA no up up no up up cAMP signaling pathway Morphine addiction 0.536521739 0 0.650707851 yes kegg kegg NA NA no up up no up up Carbohydrate digestion and absorption Morphine addiction 0 0 -0.487773488 kegg kegg NA NA no no no no up up Carbon metabolism Morphine addiction 0 -0.431818182 -0.472329472 kegg kegg NA NA no no no no up up Cardiac muscle contraction Morphine addiction 0.566086957 0.608695652 0 kegg kegg NA NA no no up no up up Cell adhesion molecules Morphine addiction 0 -0.563241107 0 kegg kegg NA NA no no no no up up Cellular senescence Morphine addiction 0 -0.416996047 0 kegg kegg NA NA no no no no up up cGMP-PKG signaling pathway Morphine addiction 0 -0.475296443 0 kegg kegg NA NA no no no no up up Cholesterol metabolism Morphine addiction 0 -0.476284585 0 yes kegg kegg NA NA no no up no up up Circadian entrainment Morphine addiction 0.657391304 0.735177866 0.845302445 kegg kegg NA NA no up up no up up Citrate cycle (TCA cycle) Morphine addiction -0.428695652 0 -0.569369369 kegg kegg NA NA no no no no up up Cocaine addiction Morphine addiction 0.772173913 0.813241107 0.873616474 kegg kegg NA NA no no no no up up Coprococcus Morphine addiction 0 0 -0.465538324 butyrate-producing Genus kegg 0.612 NA no no no no up up Cortisol synthesis and secretion Morphine addiction 0.739130435 0.778656126 0.891891892 kegg kegg NA NA no no up no up up Cushing syndrome Morphine addiction 0.793043478 0.710474308 0.680566281 kegg kegg NA NA no no up no up up DNA replication Morphine addiction -0.445217391 0 0 kegg kegg NA NA no no no no up up Dopaminergic synapse Morphine addiction 0.67826087 0.825098814 0.734620335 kegg kegg NA NA no up no no up up Drug metabolism - other enzymes Morphine addiction 0 0 -0.484427284 kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Morphine addiction 0.873043478 0.882411067 0.844787645 kegg kegg NA NA no no no no up up Endocrine resistance Morphine addiction 0.614782609 0.738142292 0.682625483 kegg kegg NA NA no no no no up up Endocytosis Morphine addiction 0 -0.536561265 0 kegg kegg NA NA no no no no up up Fanconi anemia pathway Morphine addiction -0.440869565 0 0 kegg kegg NA NA no no no no up up Fat digestion and absorption Morphine addiction 0 0 -0.46975547 yes kegg kegg NA NA no up up no up up Fatty acid biosynthesis Morphine addiction -0.412173913 -0.472332016 0 kegg kegg NA NA no no no no up up Fatty acid degradation Morphine addiction -0.664347826 -0.646245059 -0.677220077 kegg kegg NA NA no no no no up up Fatty acid metabolism Morphine addiction -0.689565217 -0.616600791 -0.566280566 kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway Morphine addiction 0 -0.45256917 0 kegg kegg NA NA no no no no up up Fc gamma R-mediated phagocytosis Morphine addiction -0.428695652 -0.633399209 0 kegg kegg NA NA no no no no up up Ferroptosis Morphine addiction 0.50173913 0 0 kegg kegg NA NA no no no no up up Fructose and mannose metabolism Morphine addiction -0.479130435 0 -0.544401544 kegg kegg NA NA no no no no up up Galactose metabolism Morphine addiction -0.55826087 -0.424901186 -0.678507079 kegg kegg NA NA no no no no up up Gap junction Morphine addiction 0.719130435 0.696640316 0.745688546 kegg kegg NA NA no no no no up up Gastric acid secretion Morphine addiction 0.506956522 0.614624506 0 kegg kegg NA NA no no no no up up Glucagon signaling pathway Morphine addiction 0.622608696 0.677865613 0.487258687 kegg kegg NA NA no no no no up up Glutamatergic synapse Morphine addiction 0.712173913 0 0.703474903 kegg kegg NA NA no up up no up up Glutathione metabolism Morphine addiction 0 0.628458498 0 kegg kegg NA NA no no no no up up Glycerolipid metabolism Morphine addiction -0.471304348 0 -0.444015444 kegg kegg NA NA no no up no up up Glycolysis / Gluconeogenesis Morphine addiction 0 0 -0.472844273 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Morphine addiction 0 0 -0.474903475 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate Morphine addiction 0.551304348 0 0 kegg kegg NA NA no no no no up up Glycosaminoglycan degradation Morphine addiction 0 -0.481225296 -0.647361647 kegg kegg NA NA no no up no up up Glyoxylate and dicarboxylate metabolism Morphine addiction -0.629565217 -0.492094862 0 kegg kegg NA NA no no no no up up GnRH signaling pathway Morphine addiction 0.764347826 0.736166008 0.802574003 kegg kegg NA NA no no no no up up "Growth hormone synthesis, secretion and action" Morphine addiction 0 0 0.547490347 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Morphine addiction -0.451304348 0 -0.44993565 kegg kegg NA NA no no no no up up Histidine metabolism Morphine addiction -0.562608696 0 -0.639382239 kegg kegg NA NA no no no no up up Homologous recombination Morphine addiction -0.459130435 0 0 kegg kegg NA NA no no no no up up Huntington disease Morphine addiction 0.495652174 0.613636364 0 kegg kegg NA NA no no no no up up IL-17 signaling pathway Morphine addiction 0 -0.477272727 0 kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels Morphine addiction 0.72 0.706521739 0.691891892 kegg kegg NA NA no no no no up up Inositol phosphate metabolism Morphine addiction -0.429565217 0 -0.433976834 kegg kegg NA NA no no no no up up Insulin secretion Morphine addiction 0.707826087 0.783596838 0.853796654 yes kegg kegg NA NA no up up no up up Linoleic acid metabolism Morphine addiction 0 0.502964427 0 kegg kegg NA NA no no no no up up Long-term depression Morphine addiction 0.899130435 0.645256917 0.881853282 kegg kegg NA NA no no no no up up Longevity regulating pathway Morphine addiction 0.415652174 0 0 kegg kegg NA NA no no no no up up Longevity regulating pathway - multiple species Morphine addiction 0 -0.589920949 0 kegg kegg NA NA no no no no up up Lysosome Morphine addiction 0 -0.479249012 0 kegg kegg NA NA no no no no up up MAPK signaling pathway Morphine addiction 0 -0.47826087 -0.495752896 kegg kegg NA NA no no no no up up Maturity onset diabetes of the young Morphine addiction 0 0.437747036 0 kegg kegg NA NA no up no no up up Melanogenesis Morphine addiction 0.775652174 0.731225296 0.776061776 kegg kegg NA NA no no no no up up Mineral absorption Morphine addiction 0.671304348 0.621541502 0.479279279 kegg kegg NA NA no no no no up up Mismatch repair Morphine addiction -0.492173913 0 0 kegg kegg NA NA no no no no up up Mitophagy - animal Morphine addiction 0.575652174 0.532608696 0 kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis Morphine addiction 0 -0.473320158 0 kegg kegg NA NA no no no no up up Natural killer cell mediated cytotoxicity Morphine addiction 0 -0.467391304 0 kegg kegg NA NA no no no no up up Necroptosis Morphine addiction 0.533043478 0.427865613 0 kegg kegg NA NA no no no no up up Neuroactive ligand-receptor interaction Morphine addiction 0 -0.584980237 0 kegg kegg NA NA up up up no up up Neutrophil extracellular trap formation Morphine addiction 0 -0.416007905 0 kegg kegg NA NA no no no no up up NF-kappa B signaling pathway Morphine addiction -0.571304348 0 0 kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Morphine addiction -0.47826087 0 0 kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Morphine addiction -0.557391304 -0.682806324 0 kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease Morphine addiction 0.562608696 0.580039526 0.484169884 kegg kegg NA NA no no no no up up Non-homologous end-joining Morphine addiction -0.414782609 0 0 kegg kegg NA NA no no no no up up Nucleotide excision repair Morphine addiction -0.43826087 0 0 kegg kegg NA NA no no no no up up Odoribacter Morphine addiction -0.426114464 -0.496782108 0 butyrate-producing Genus kegg 0.798 NA no no no no up up Olfactory transduction Morphine addiction 0 -0.434782609 0 kegg kegg NA NA no no no no up up Oscillospira Morphine addiction 0 -0.4743083 0 LPS-producing Genus kegg 0.62 NA no no no no up up Osteoclast differentiation Morphine addiction -0.457391304 -0.640316206 0 kegg kegg NA NA no no no no up up Other glycan degradation Morphine addiction -0.590434783 0 -0.498326898 kegg kegg NA NA no no no no up up Ovarian steroidogenesis Morphine addiction 0.673913043 0.821146245 0.85045045 kegg kegg NA NA no up up no up up Oxidative phosphorylation Morphine addiction 0.5 0.586956522 0 kegg kegg NA NA no no no no up up Pancreatic secretion Morphine addiction 0.906956522 0.888339921 0.934620335 kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis Morphine addiction 0 -0.515810277 -0.507078507 kegg kegg NA NA no no dn no up up "Parathyroid hormone synthesis, secretion and action" Morphine addiction 0.609565217 0.632411067 0.623680824 kegg kegg NA NA no no no no up up Parkinson disease Morphine addiction 0.664347826 0.58201581 0.534620335 kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases Morphine addiction 0.660869565 0.566205534 0.497039897 kegg kegg NA NA no no no no up up Pentose phosphate pathway Morphine addiction 0 -0.468379447 0 kegg kegg NA NA no no no no up up Peroxisome Morphine addiction -0.664347826 -0.666996047 0 kegg kegg NA NA no no no no up up Phagosome Morphine addiction 0 -0.47826087 0 kegg kegg NA NA no no no no up up Platelet activation Morphine addiction 0 0.507905138 0 kegg kegg NA NA no no no no up up PPAR signaling pathway Morphine addiction -0.408695652 -0.675889328 0 kegg kegg NA NA no no no no up up Prevotella Morphine addiction -0.415215659 0 0 Genus kegg 0.367 NA no no no no up up Prevotella Morphine addiction 0 0 0.446718193 acetate-producing Genus kegg 0.287 NA no no no no up up Primary bile acid biosynthesis Morphine addiction -0.51826087 0 0 kegg kegg NA NA no no no no up up Prion disease Morphine addiction 0.496521739 0.499011858 0 kegg kegg NA NA no no no no up up Propanoate metabolism Morphine addiction -0.406086957 0 0 kegg kegg NA NA no no no no up up Proteasome Morphine addiction 0 0 -0.474131274 kegg kegg NA NA no no no no up up Protein digestion and absorption Morphine addiction -0.634782609 -0.742094862 -0.504247104 yes kegg kegg NA NA no up up no up up Pyrimidine metabolism Morphine addiction -0.513913043 0 0 kegg kegg NA NA no no no no up up Pyruvate metabolism Morphine addiction -0.452173913 0 0 kegg kegg NA NA no no no no up up Rap1 signaling pathway Morphine addiction 0 0.43972332 0 kegg kegg NA NA no no no no up up Regulation of lipolysis in adipocytes Morphine addiction 0.793043478 0.899209486 0.862033462 kegg kegg NA NA no no no no up up Relaxin signaling pathway Morphine addiction 0.48173913 0 0.661518662 kegg kegg NA NA no no no no up up Renin secretion Morphine addiction 0.688695652 0.679841897 0.759073359 kegg kegg NA NA no no no no up up Renin-angiotensin system Morphine addiction 0 -0.566205534 0 kegg kegg NA NA no no no no up up Retinol metabolism Morphine addiction -0.5 0 -0.507593308 kegg kegg NA NA no no no no up up Retrograde endocannabinoid signaling Morphine addiction 0 0.634387352 0 kegg kegg NA NA no no up no up up Ribosome Morphine addiction 0 0.470355731 0 kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway Morphine addiction 0 -0.454545455 0 kegg kegg NA NA no no no no up up Salivary secretion Morphine addiction 0.670434783 0.585968379 0.619305019 kegg kegg NA NA no no no no up up Selenocompound metabolism Morphine addiction 0 0 -0.446589447 kegg kegg NA NA no no no no up up Serotonergic synapse Morphine addiction 0.487826087 0.583992095 0.657400257 kegg kegg NA NA no no no no up up SNARE interactions in vesicular transport Morphine addiction -0.631304348 -0.461462451 0 kegg kegg NA NA no no no no up up Sphingolipid metabolism Morphine addiction 0 0 -0.494980695 kegg kegg NA NA no no no no up up Sphingolipid signaling pathway Morphine addiction 0 -0.47826087 0 kegg kegg NA NA no no no no up up Spinocerebellar ataxia Morphine addiction 0 0 -0.435778636 kegg kegg NA NA no no no no up up Starch and sucrose metabolism Morphine addiction -0.433913043 -0.499011858 -0.579150579 kegg kegg NA NA no no no no up up Steroid hormone biosynthesis Morphine addiction 0 0 -0.556499356 kegg kegg NA NA no no no no up up Synaptic vesicle cycle Morphine addiction 0 -0.457509881 -0.426512227 kegg kegg NA NA no up up no up up T cell receptor signaling pathway Morphine addiction 0 -0.572134387 0 kegg kegg NA NA no no no no up up Th1 and Th2 cell differentiation Morphine addiction 0 -0.524703557 0 kegg kegg NA NA no no no no up up Th17 cell differentiation Morphine addiction 0 -0.625494071 0 kegg kegg NA NA no no no no up up Thermogenesis Morphine addiction 0.562608696 0.574110672 0 kegg kegg NA NA no no no no up up Thyroid hormone signaling pathway Morphine addiction 0 0.595849802 0 kegg kegg NA NA no no no no up up Thyroid hormone synthesis Morphine addiction 0.625217391 0.885375494 0.69009009 kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway Morphine addiction 0 -0.462450593 0 yes kegg kegg NA NA no no no no up up Tryptophan metabolism Morphine addiction -0.524347826 0 -0.595624196 kegg kegg NA NA no up no no up up Type I diabetes mellitus Morphine addiction 0 -0.438735178 0 kegg kegg NA NA no no no no up up Type II diabetes mellitus Morphine addiction 0 0 -0.453024453 kegg kegg NA NA no no no no up up Ubiquinone and other terpenoid-quinone biosynthesis Morphine addiction -0.472173913 0 0 kegg kegg NA NA no no no no up up Ubiquitin mediated proteolysis Morphine addiction 0.562608696 0.550395257 0 kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" Morphine addiction -0.54173913 0 -0.431145431 kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Morphine addiction 0.775652174 0.634387352 0.723037323 kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption Morphine addiction 0.829565217 0.921936759 0.897812098 kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor Morphine addiction 0 0 0.426254826 kegg kegg NA NA no no no no up up Wnt signaling pathway Morphine addiction 0.524347826 0.448616601 0 kegg kegg NA NA no no no no up up 2-Oxocarboxylic acid metabolism mRNA surveillance pathway -0.530434783 0.554347826 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" mRNA surveillance pathway 0 -0.721343874 -0.634749035 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism mRNA surveillance pathway -0.686956522 -0.674901186 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism mRNA surveillance pathway -0.622608696 0 0 kegg kegg NA NA no no no no no no Antifolate resistance mRNA surveillance pathway 0 0 0.451994852 kegg kegg NA NA no no no no no no Arachidonic acid metabolism mRNA surveillance pathway 0 0 -0.583783784 kegg kegg NA NA no no no no no no Arginine and proline metabolism mRNA surveillance pathway 0 -0.678853755 -0.484427284 kegg kegg NA NA no up no no no no Arginine biosynthesis mRNA surveillance pathway -0.410434783 -0.76284585 -0.732818533 kegg kegg NA NA no no no no no no beta-Alanine metabolism mRNA surveillance pathway -0.706956522 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids mRNA surveillance pathway -0.907826087 -0.852766798 -0.867438867 kegg kegg NA NA no no no no no no Biosynthesis of cofactors mRNA surveillance pathway 0 0.446640316 0 kegg kegg NA NA no no no no no no Butanoate metabolism mRNA surveillance pathway -0.486956522 0 0 kegg kegg NA NA no no no no no no Carbon metabolism mRNA surveillance pathway -0.802608696 -0.43083004 -0.682625483 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism mRNA surveillance pathway 0 0 0.407464607 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 mRNA surveillance pathway 0 0.473320158 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes mRNA surveillance pathway -0.656521739 0.437747036 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance mRNA surveillance pathway 0.514782609 0.567193676 0.44015444 kegg kegg NA NA no no no no no no Endocrine resistance mRNA surveillance pathway 0.457391304 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism mRNA surveillance pathway 0.755652174 0.621541502 0.533333333 kegg kegg NA NA no no no no no no Fatty acid biosynthesis mRNA surveillance pathway 0 -0.789525692 0 kegg kegg NA NA no no no no no no Fatty acid degradation mRNA surveillance pathway -0.577391304 -0.631422925 0 kegg kegg NA NA no no no no no no Fatty acid elongation mRNA surveillance pathway -0.532173913 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism mRNA surveillance pathway -0.672173913 -0.73715415 0 kegg kegg NA NA no no no no no no Folate biosynthesis mRNA surveillance pathway 0 0.696640316 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism mRNA surveillance pathway -0.705217391 0 0 kegg kegg NA NA no no no no no no Galactose metabolism mRNA surveillance pathway -0.686956522 -0.567193676 0 kegg kegg NA NA no no no no no no Glutathione metabolism mRNA surveillance pathway 0 0.489130435 -0.472329472 kegg kegg NA NA no no no no no no Glycerolipid metabolism mRNA surveillance pathway 0 0 0.588674389 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism mRNA surveillance pathway 0.453043478 0 0.701930502 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis mRNA surveillance pathway -0.760869565 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin mRNA surveillance pathway -0.447826087 0.518774704 0.412870013 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate mRNA surveillance pathway 0.530434783 0.634387352 0.526640927 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation mRNA surveillance pathway 0 -0.445652174 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series mRNA surveillance pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series mRNA surveillance pathway 0.613913043 0 0.508365508 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism mRNA surveillance pathway -0.475652174 -0.772727273 -0.714543115 kegg kegg NA NA no no no no no no Inositol phosphate metabolism mRNA surveillance pathway 0 0 0.58996139 kegg kegg NA NA no no no no no no Lysine degradation mRNA surveillance pathway 0.506086957 0.62944664 0.861261261 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis mRNA surveillance pathway 0.699130435 0.640316206 0.827799228 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 mRNA surveillance pathway -0.460869565 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis mRNA surveillance pathway 0.42173913 0.790513834 0.656628057 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism mRNA surveillance pathway 0 -0.782608696 -0.574774775 kegg kegg NA NA no no no no no no Nitrogen metabolism mRNA surveillance pathway -0.49826087 -0.706521739 -0.625740026 kegg kegg NA NA no no no no no no One carbon pool by folate mRNA surveillance pathway 0 0.5 0.575804376 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis mRNA surveillance pathway 0.677391304 0.539525692 0.784298584 kegg kegg NA NA no no no no no no Oxidative phosphorylation mRNA surveillance pathway 0.68 0.625494071 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis mRNA surveillance pathway 0 -0.808300395 -0.519176319 kegg kegg NA NA no no dn no no no Parabacteroides mRNA surveillance pathway -0.48 0 0 Genus kegg 4.19E-05 NA no up up no no no Pentose and glucuronate interconversions mRNA surveillance pathway 0 0.638339921 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway mRNA surveillance pathway -0.614782609 -0.861660079 -0.788416988 kegg kegg NA NA no no no no no no Phenylalanine metabolism mRNA surveillance pathway -0.52173913 0 0 kegg kegg NA NA no no no no no no Platinum drug resistance mRNA surveillance pathway 0 0 0.45045045 kegg kegg NA NA no no no no no no Purine metabolism mRNA surveillance pathway 0 0.460474308 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism mRNA surveillance pathway -0.588695652 0.418972332 0 kegg kegg NA NA no no no no no no Pyruvate metabolism mRNA surveillance pathway 0 0.456521739 0 kegg kegg NA NA no no no no no no Retinol metabolism mRNA surveillance pathway -0.553043478 0 0 kegg kegg NA NA no no no no no no Ribosome mRNA surveillance pathway 0.762608696 0.566205534 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes mRNA surveillance pathway 0.52173913 0.647233202 0.784041184 kegg kegg NA NA no no no no no no RNA transport mRNA surveillance pathway 0 0.516798419 0 kegg kegg NA NA no no no no no no Selenocompound metabolism mRNA surveillance pathway 0.50173913 0 0.520978121 kegg kegg NA NA no no no no no no Starch and sucrose metabolism mRNA surveillance pathway -0.577391304 -0.754940711 0 kegg kegg NA NA no no no no no no Steroid biosynthesis mRNA surveillance pathway 0.433043478 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism mRNA surveillance pathway 0 0 -0.564478764 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism mRNA surveillance pathway 0 0 0.510682111 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis mRNA surveillance pathway 0.42173913 0 0.558301158 kegg kegg NA NA no no no no no no Tryptophan metabolism mRNA surveillance pathway -0.504347826 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism mRNA surveillance pathway -0.509565217 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis mRNA surveillance pathway 0 0.717391304 0.55958816 kegg kegg NA NA no no no no no no ABC transporters mTOR signaling pathway 0 -0.458498024 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" mTOR signaling pathway 0 -0.577075099 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism mTOR signaling pathway 0 -0.790513834 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism mTOR signaling pathway 0 -0.56916996 0 kegg kegg NA NA no up no no no no Arginine biosynthesis mTOR signaling pathway 0 -0.545454545 0 kegg kegg NA NA no no no no no no Autophagy - animal mTOR signaling pathway 0 -0.504940711 0 kegg kegg NA NA no no no no no no Autophagy - other mTOR signaling pathway 0.540869565 0 0 kegg kegg NA NA no no no no no no Basal transcription factors mTOR signaling pathway 0.486086957 0 0.481338481 kegg kegg NA NA no no no no no no Base excision repair mTOR signaling pathway 0.473043478 0 0.453281853 kegg kegg NA NA no no no no no no Biosynthesis of amino acids mTOR signaling pathway 0 -0.435770751 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors mTOR signaling pathway 0 0.440711462 0 kegg kegg NA NA no no no no no no Butanoate metabolism mTOR signaling pathway 0 0.535573123 0.557528958 kegg kegg NA NA no no no no no no Calcium signaling pathway mTOR signaling pathway 0 0.41798419 0 kegg kegg NA NA no up up no no no Cell cycle mTOR signaling pathway 0.413043478 0.422924901 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway mTOR signaling pathway 0 -0.511857708 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway mTOR signaling pathway 0 -0.421936759 -0.509395109 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) mTOR signaling pathway 0 0.513833992 0.466924067 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism mTOR signaling pathway 0 0.741106719 0.594079794 kegg kegg NA NA no no no no no no DNA replication mTOR signaling pathway 0.423478261 0.48715415 0.515057915 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 mTOR signaling pathway 0 0.533596838 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes mTOR signaling pathway 0 0.540513834 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance mTOR signaling pathway 0.966956522 0.98715415 0.966280566 kegg kegg NA NA no no no no no no Fatty acid biosynthesis mTOR signaling pathway 0 -0.615612648 0 kegg kegg NA NA no no no no no no Fatty acid degradation mTOR signaling pathway 0 -0.479249012 0 kegg kegg NA NA no no no no no no Fatty acid metabolism mTOR signaling pathway 0 -0.475296443 0 kegg kegg NA NA no no no no no no FoxO signaling pathway mTOR signaling pathway 0 -0.557312253 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism mTOR signaling pathway 0 -0.571146245 0 kegg kegg NA NA no no no no no no Galactose metabolism mTOR signaling pathway 0 -0.698616601 0 kegg kegg NA NA no no no no no no Glutathione metabolism mTOR signaling pathway 0 0.675889328 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism mTOR signaling pathway 0 -0.593873518 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism mTOR signaling pathway 0 -0.445652174 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis mTOR signaling pathway 0 0.631422925 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate mTOR signaling pathway 0 -0.666007905 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation mTOR signaling pathway 0 -0.596837945 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series mTOR signaling pathway 0 -0.437747036 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism mTOR signaling pathway 0 -0.506916996 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway mTOR signaling pathway 0.919130435 0.944664032 0.941312741 kegg kegg NA NA no no no no no no Lysine degradation mTOR signaling pathway 0.709565217 0 0 kegg kegg NA NA no no no no no no Lysosome mTOR signaling pathway -0.469565217 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis mTOR signaling pathway 0.445217391 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 mTOR signaling pathway 0 0.458498024 0 kegg kegg NA NA no no no no no no Mismatch repair mTOR signaling pathway 0 0.425889328 0 kegg kegg NA NA no no no no no no Mitophagy - animal mTOR signaling pathway 0.523478261 0.589920949 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway mTOR signaling pathway 0.473043478 0.583003953 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis mTOR signaling pathway 0 0.570158103 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction mTOR signaling pathway 0 -0.480237154 0 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway mTOR signaling pathway 0 -0.624505929 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism mTOR signaling pathway 0 -0.672924901 0 kegg kegg NA NA no no no no no no Nitrogen metabolism mTOR signaling pathway 0 -0.476284585 0 kegg kegg NA NA no no no no no no Non-homologous end-joining mTOR signaling pathway 0 0.416007905 0.430888031 kegg kegg NA NA no no no no no no Nucleotide excision repair mTOR signaling pathway 0 0 0.472586873 kegg kegg NA NA no no no no no no Oocyte meiosis mTOR signaling pathway 0 0.604743083 0 kegg kegg NA NA no no no no no no Other glycan degradation mTOR signaling pathway 0 -0.519762846 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis mTOR signaling pathway 0.472173913 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation mTOR signaling pathway 0 0.65513834 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis mTOR signaling pathway -0.462608696 -0.700592885 0 kegg kegg NA NA no no dn no no no Parabacteroides mTOR signaling pathway 0 0 -0.469270868 Genus kegg 4.19E-05 NA no up up no no no Pentose and glucuronate interconversions mTOR signaling pathway 0 0.536561265 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway mTOR signaling pathway 0 -0.5 0 kegg kegg NA NA no no no no no no Peroxisome mTOR signaling pathway 0 -0.568181818 0 kegg kegg NA NA no no no no no no Phagosome mTOR signaling pathway -0.464347826 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway mTOR signaling pathway 0 -0.754940711 -0.537194337 kegg kegg NA NA no up up no no no Propanoate metabolism mTOR signaling pathway 0 0.757905138 0.689317889 kegg kegg NA NA no no no no no no Proteasome mTOR signaling pathway 0 0.515810277 0.492921493 kegg kegg NA NA no no no no no no Protein export mTOR signaling pathway 0.555652174 0.739130435 0.540540541 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum mTOR signaling pathway 0.493043478 0.639328063 0.640926641 kegg kegg NA NA no no no no no no Pyruvate metabolism mTOR signaling pathway 0 0.791501976 0.641956242 kegg kegg NA NA no no no no no no Rap1 signaling pathway mTOR signaling pathway -0.469565217 0 -0.476962677 kegg kegg NA NA no no no no no no Ras signaling pathway mTOR signaling pathway 0 0.43972332 0 yes kegg kegg NA NA no up up no no no Ribosome mTOR signaling pathway 0.709565217 0.888339921 0.784041184 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes mTOR signaling pathway 0.603478261 0 0.43989704 kegg kegg NA NA no no no no no no RNA degradation mTOR signaling pathway 0.513913043 0.690711462 0.465637066 kegg kegg NA NA no no no no no no RNA polymerase mTOR signaling pathway 0.536521739 0.550395257 0.544144144 kegg kegg NA NA no no no no no no RNA transport mTOR signaling pathway 0.584347826 0.951581028 0.730759331 kegg kegg NA NA no no no no no no Selenocompound metabolism mTOR signaling pathway 0.460869565 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport mTOR signaling pathway 0 -0.602766798 0 kegg kegg NA NA no no no no no no Spliceosome mTOR signaling pathway 0.594782609 0 0.444015444 kegg kegg NA NA no no no no no no Starch and sucrose metabolism mTOR signaling pathway 0 -0.741106719 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism mTOR signaling pathway 0 -0.425889328 0 kegg kegg NA NA no no no no no no Thiamine metabolism mTOR signaling pathway 0 0.743083004 0 kegg kegg NA NA no no no no no no Tryptophan metabolism mTOR signaling pathway 0 0 0.508880309 kegg kegg NA NA no up no no no no Ubiquitin mediated proteolysis mTOR signaling pathway 0.566956522 0.599802372 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" mTOR signaling pathway 0 0 0.42985843 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis mTOR signaling pathway 0.525217391 0.460474308 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Mucin type O-glycan biosynthesis 0.449565217 0 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Mucin type O-glycan biosynthesis 0.725217391 0 0 kegg kegg NA NA no no no no no no Fatty acid degradation Mucin type O-glycan biosynthesis 0 0.432806324 0 kegg kegg NA NA no no no no no no Fatty acid elongation Mucin type O-glycan biosynthesis 0.445217391 0 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Mucin type O-glycan biosynthesis 0.567826087 0 0 kegg kegg NA NA no no no no no no Lysine degradation Mucin type O-glycan biosynthesis 0 0.535573123 0 kegg kegg NA NA no no no no no no Other glycan degradation Mucin type O-glycan biosynthesis 0 0.453557312 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Mucin type O-glycan biosynthesis 0 -0.440711462 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Mucin type O-glycan biosynthesis 0.613043478 0 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Mucin type O-glycan biosynthesis 0.615652174 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Mucin type O-glycan biosynthesis 0.479130435 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Mucin type O-glycan biosynthesis 0 0.623517787 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Mucin type O-glycan biosynthesis 0.572173913 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Mucin type O-glycan biosynthesis 0.548695652 0 0.435778636 kegg kegg NA NA no no no no no no Tryptophan metabolism Mucin type O-glycan biosynthesis 0.433913043 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Mucin type O-glycan biosynthesis 0.48173913 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Mucin type O-glycan biosynthesis 0.512173913 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Mucin type O-glycan biosynthesis 0.502608696 0 0 kegg kegg NA NA no no no no no no 12-ketoDCA+blood MUFA%+blood -0.584006029 0 0 serum_bileacids serum_fattyacid 0.517 0.00142 no no no up no dn 12-ketoDCA+stool MUFA%+blood 0 -0.697040533 0 stool_bileacids serum_fattyacid 0.505 0.00142 no no no up no dn 13-HODE+blood MUFA%+blood 0.565413534 0 0 serum_ARA serum_fattyacid 0.32 0.00142 no no no up no dn 14:0-LPC+blood MUFA%+blood -0.508270677 0 -0.40034188 serum_phospholipids serum_fattyacid 0.00689 0.00142 up up no up no dn 14:0/16:0-PC+blood MUFA%+blood -0.454135338 0 0 serum_phospholipids serum_fattyacid 0.0358 0.00142 no up no up no dn 14:0/18:2-PC+blood MUFA%+blood 0 -0.482843137 -0.506324786 serum_phospholipids serum_fattyacid 0.102 0.00142 no up no up no dn 14:0/20:4-PC+blood MUFA%+blood 0 0 -0.58017094 serum_phospholipids serum_fattyacid 0.486 0.00142 no no no up no dn 14:1/18:2-PG+blood MUFA%+blood 0 0 -0.423589744 serum_phospholipids serum_fattyacid 0.00259 0.00142 no up up up no dn 16:0/16:0-PI+blood MUFA%+blood -0.577443609 0 -0.44 serum_phospholipids serum_fattyacid 0.358 0.00142 no no no up no dn 16:0/16:1-PI+blood MUFA%+blood -0.732330827 0 0 serum_phospholipids serum_fattyacid 0.262 0.00142 no no no up no dn 16:0/18:1-PC+blood MUFA%+blood 0.607518797 0 0.498119658 serum_phospholipids serum_fattyacid 6.15E-07 0.00142 up up up up no dn 16:0/18:1-PE+blood MUFA%+blood -0.454135338 0 0 serum_phospholipids serum_fattyacid 0.000107 0.00142 up up no up no dn 16:0/18:2-PC+blood MUFA%+blood 0.526315789 0.5 0.569230769 serum_phospholipids serum_fattyacid 3.24E-06 0.00142 no up up up no dn 16:0/18:2-PI+blood MUFA%+blood -0.592481203 0 -0.414017094 serum_phospholipids serum_fattyacid 0.269 0.00142 no no no up no dn 16:0/20:3-PC+blood MUFA%+blood 0.514285714 0 0 serum_phospholipids serum_fattyacid 5.43E-06 0.00142 no up up up no dn 16:0/20:4-PI+blood MUFA%+blood -0.711278195 0 -0.468034188 serum_phospholipids serum_fattyacid 0.558 0.00142 no no no up no dn 16:0/20:5-PC+blood MUFA%+blood 0 0 -0.410598291 serum_phospholipids serum_fattyacid 0.628 0.00142 no no no up no dn 16:0/22:6-PC+blood MUFA%+blood 0 0 0.42974359 serum_phospholipids serum_fattyacid 4.53E-05 0.00142 no up up up no dn 16:1-LPC+blood MUFA%+blood 0 0.531862745 0 serum_phospholipids serum_fattyacid 0.0241 0.00142 no up no up no dn 16:1/16:0-PC+blood MUFA%+blood 0.547368421 0.517156863 0.401025641 serum_phospholipids serum_fattyacid 0.0215 0.00142 no up up up no dn 16:1/16:1-PC+blood MUFA%+blood 0.518796992 0 0 serum_phospholipids serum_fattyacid 0.0177 0.00142 no no up up no dn 16:1/18:2-PG+blood MUFA%+blood 0.556390977 0 0 serum_phospholipids serum_fattyacid 1.40E-08 0.00142 no up up up no dn 16:1+blood MUFA%+blood 0.520300752 0 0 yes serum_fattyacid serum_fattyacid 0.0186 0.00142 no no dn up no dn 18:0-LPA+blood MUFA%+blood 0 0.664215686 0 serum_phospholipids serum_fattyacid 0.0725 0.00142 no dn no up no dn 18:0/16:0-PC+blood MUFA%+blood 0.613533835 0 0.482393162 serum_phospholipids serum_fattyacid 9.64E-07 0.00142 up up up up no dn 18:0/18:0-PE+blood MUFA%+blood -0.645112782 0 0 serum_phospholipids serum_fattyacid 0.00896 0.00142 up up no up no dn 18:0/18:1-PE+blood MUFA%+blood -0.664661654 0 0 serum_phospholipids serum_fattyacid 0.00716 0.00142 up up no up no dn 18:0/18:2-PC+blood MUFA%+blood 0.545864662 0 0 serum_phospholipids serum_fattyacid 1.74E-06 0.00142 no up up up no dn 18:1-LPC+blood MUFA%+blood 0.586466165 0 0 serum_phospholipids serum_fattyacid 0.179 0.00142 no no no up no dn 18:1/16:0-PC+blood MUFA%+blood 0.515789474 0.490196078 0.593846154 serum_phospholipids serum_fattyacid 2.43E-05 0.00142 no up up up no dn 18:1/16:0-PE+blood MUFA%+blood -0.592481203 0 0 serum_phospholipids serum_fattyacid 0.000182 0.00142 up up no up no dn 18:1/16:0-PI+blood MUFA%+blood -0.532330827 0 0 serum_phospholipids serum_fattyacid 0.793 0.00142 no no no up no dn 18:1/16:1-PE+blood MUFA%+blood -0.515789474 0 0 serum_phospholipids serum_fattyacid 0.000184 0.00142 up up no up no dn 18:1/18:0-PC+blood MUFA%+blood 0.49924812 0 0 serum_phospholipids serum_fattyacid 1.83E-06 0.00142 no up up up no dn 18:1/18:0-PS+blood MUFA%+blood 0.490225564 0 0 serum_phospholipids serum_fattyacid 0.193 0.00142 no no no up no dn 18:1/18:2-PG+blood MUFA%+blood 0.521804511 0 0 serum_phospholipids serum_fattyacid 5.58E-07 0.00142 no up up up no dn 18:1/20:4-PC+blood MUFA%+blood 0.472180451 0 0 serum_phospholipids serum_fattyacid 0.582 0.00142 no no no up no dn 18:1+blood MUFA%+blood 0.47518797 0.590686275 0.556239316 yes serum_fattyacid serum_fattyacid 0.00202 0.00142 up no dn up no dn 18:2/16:0-PC+blood MUFA%+blood 0.529323308 0 0 serum_phospholipids serum_fattyacid 8.67E-05 0.00142 no up up up no dn 18:3/16:0-PE+blood MUFA%+blood -0.535338346 0 -0.434529915 serum_phospholipids serum_fattyacid 0.00149 0.00142 up up no up no dn 18:3n3+blood MUFA%+blood 0.52481203 0 0 serum_fattyacid serum_fattyacid 0.291 0.00142 no no no up no dn 18:3n6+blood MUFA%+blood -0.521804511 0 0 serum_fattyacid serum_fattyacid 0.0463 0.00142 up no dn up no dn 20:0/20:4-PE+blood MUFA%+blood 0 -0.607843137 0 serum_phospholipids serum_fattyacid 0.00128 0.00142 up up no up no dn 20:0/20:5-PC+blood MUFA%+blood 0.527819549 0 0 serum_phospholipids serum_fattyacid 0.882 0.00142 no no no up no dn 20:1-LPA+blood MUFA%+blood 0 0.544117647 0 serum_phospholipids serum_fattyacid 0.0187 0.00142 dn dn no up no dn 20:2+blood MUFA%+blood 0 0 0.503589744 serum_fattyacid serum_fattyacid 0.478 0.00142 no no no up no dn 20:4/16:0-PE+blood MUFA%+blood 0 0 -0.459145299 serum_phospholipids serum_fattyacid 0.00529 0.00142 no up up up no dn 20:5/18:0-PC+blood MUFA%+blood 0 0 0.463931624 serum_phospholipids serum_fattyacid 3.97E-06 0.00142 no up up up no dn 22:1-LPA+blood MUFA%+blood 0 0.504901961 0 serum_phospholipids serum_fattyacid 0.00373 0.00142 no up up up no dn AA+blood MUFA%+blood 0.607518797 0 0 serum_ARA serum_fattyacid 0.212 0.00142 no no no up no dn ACA+stool MUFA%+blood 0.595146513 0 0 stool_bileacids serum_fattyacid 0.417 0.00142 no no no up no dn Adrenergic signaling in cardiomyocytes MUFA%+blood 0 -0.555882353 -0.456153846 kegg serum_fattyacid NA 0.00142 no no up up no dn Aldosterone synthesis and secretion MUFA%+blood 0 -0.538235294 -0.5 kegg serum_fattyacid NA 0.00142 no up up up no dn Amphetamine addiction MUFA%+blood 0 0 -0.443846154 kegg serum_fattyacid NA 0.00142 no no no up no dn Antigen processing and presentation MUFA%+blood 0 0 0.433076923 kegg serum_fattyacid NA 0.00142 no no no up no dn Apelin signaling pathway MUFA%+blood 0 -0.561764706 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Arginine and proline metabolism MUFA%+blood 0 0 0.404615385 kegg serum_fattyacid NA 0.00142 no up no up no dn B cell receptor signaling pathway MUFA%+blood 0.529824561 0 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Biosynthesis of amino acids MUFA%+blood 0 0.505882353 0.451538462 kegg serum_fattyacid NA 0.00142 no no no up no dn Biosynthesis of cofactors MUFA%+blood -0.589473684 0 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Blautia MUFA%+blood 0 0.529411765 0 acetate-producing Genus serum_fattyacid 1.36E-05 0.00142 up dn dn up no dn Butyricimonas MUFA%+blood 0 -0.568887169 0 butyrate-producing Genus serum_fattyacid 0.17 0.00142 no no no up no dn CA+blood MUFA%+blood 0 -0.53832015 -0.569128563 serum_bileacids serum_fattyacid 0.606 0.00142 no no no up no dn Calcium signaling pathway MUFA%+blood 0 -0.517647059 -0.526923077 kegg serum_fattyacid NA 0.00142 no up up up no dn capric acid C6+blood MUFA%+blood 0 0 0.444786325 serum_scfa serum_fattyacid 0.433 0.00142 no no no up no dn Carbon metabolism MUFA%+blood 0 0 0.582307692 kegg serum_fattyacid NA 0.00142 no no no up no dn CDCA+blood MUFA%+blood 0 0 -0.541880342 serum_bileacids serum_fattyacid 0.506 0.00142 no no no up no dn cGMP-PKG signaling pathway MUFA%+blood 0 0 0.41 kegg serum_fattyacid NA 0.00142 no no no up no dn Chemical carcinogenesis - receptor activation MUFA%+blood 0 -0.541176471 -0.493076923 kegg serum_fattyacid NA 0.00142 no no no up no dn Chemokine signaling pathway MUFA%+blood 0.478947368 0 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Choline metabolism in cancer MUFA%+blood 0 0 -0.406923077 kegg serum_fattyacid NA 0.00142 no no no up no dn Cocaine addiction MUFA%+blood 0 0 -0.500769231 kegg serum_fattyacid NA 0.00142 no no no up no dn Colorectal cancer MUFA%+blood 0 -0.558823529 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Coprococcus MUFA%+blood -0.562406015 0 0 butyrate-producing Genus serum_fattyacid 0.612 0.00142 no no no up no dn Coronavirus disease - COVID-19 MUFA%+blood 0 -0.570588235 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Cortisol synthesis and secretion MUFA%+blood 0 0 -0.629230769 kegg serum_fattyacid NA 0.00142 no no up up no dn Creatinine+blood MUFA%+blood 0.661654135 0.534313725 0.646495726 serum_choline serum_fattyacid 0.437 0.00142 no no no up no dn Cushing syndrome MUFA%+blood 0 -0.564705882 -0.657692308 kegg serum_fattyacid NA 0.00142 no no up up no dn Cysteine+blood MUFA%+blood 0 0.49754902 0.673846154 yes serum_aminoacids serum_fattyacid 1.81E-07 0.00142 dn up up up no dn Cystine+blood MUFA%+blood 0.445112782 0.691176471 0.552820513 yes serum_aminoacids serum_fattyacid 0.00028 0.00142 up up no up no dn d18:1-14:0-SM+blood MUFA%+blood 0 -0.531862745 -0.486495726 serum_phospholipids serum_fattyacid 0.94 0.00142 no no no up no dn d18:1-14:1-SM+blood MUFA%+blood 0 -0.541666667 -0.483076923 serum_phospholipids serum_fattyacid 0.0952 0.00142 no dn no up no dn d18:1-16:1-SM+blood MUFA%+blood 0 -0.504901961 -0.419487179 serum_phospholipids serum_fattyacid 0.2 0.00142 no no no up no dn d18:1-18:0-SM+blood MUFA%+blood 0.583458647 0 0 serum_phospholipids serum_fattyacid 0.97 0.00142 no no no up no dn d18:1-18:1-SM+blood MUFA%+blood 0.497744361 0 0 serum_phospholipids serum_fattyacid 0.916 0.00142 no no no up no dn d18:1-20:1-SM+blood MUFA%+blood 0.512781955 0 0 serum_phospholipids serum_fattyacid 0.0992 0.00142 no no no up no dn DCA+blood MUFA%+blood 0 0 -0.45982906 serum_bileacids serum_fattyacid 0.122 0.00142 no no no up no dn Dopaminergic synapse MUFA%+blood 0 -0.526470588 0 kegg serum_fattyacid NA 0.00142 no up no up no dn EGFR tyrosine kinase inhibitor resistance MUFA%+blood 0 -0.617647059 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Endocrine and other factor-regulated calcium reabsorption MUFA%+blood 0 0 -0.467692308 kegg serum_fattyacid NA 0.00142 no no no up no dn Endocrine resistance MUFA%+blood 0 -0.526470588 -0.625384615 kegg serum_fattyacid NA 0.00142 no no no up no dn Endocytosis MUFA%+blood 0 0.55 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Epithelial cell signaling in Helicobacter pylori infection MUFA%+blood 0.505263158 0 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Fc epsilon RI signaling pathway MUFA%+blood 0.540350877 0 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Fc gamma R-mediated phagocytosis MUFA%+blood 0 0.585294118 0.623846154 kegg serum_fattyacid NA 0.00142 no no no up no dn Fusobacterium MUFA%+blood 0 0 0.462650554 Genus serum_fattyacid 0.628 0.00142 no no no up no dn Gastric cancer MUFA%+blood 0 0 -0.456923077 kegg serum_fattyacid NA 0.00142 no no no up no dn GCDCA+blood MUFA%+blood -0.523308271 0 0 serum_bileacids serum_fattyacid 0.31 0.00142 no no no up no dn Glucagon signaling pathway MUFA%+blood 0 0 -0.495384615 kegg serum_fattyacid NA 0.00142 no no no up no dn "Glycine, serine and threonine metabolism" MUFA%+blood -0.561403509 0 0 kegg serum_fattyacid NA 0.00142 no up no up no dn Glycine+blood MUFA%+blood 0 0.536764706 0.459145299 serum_aminoacids serum_fattyacid 0.00408 0.00142 dn no up up no dn "Growth hormone synthesis, secretion and action" MUFA%+blood 0 0 -0.586153846 kegg serum_fattyacid NA 0.00142 no no no up no dn HCA+blood MUFA%+blood -0.520427215 -0.502312258 0 serum_bileacids serum_fattyacid 0.544 0.00142 no no no up no dn HIF-1 signaling pathway MUFA%+blood 0 -0.532352941 0 kegg serum_fattyacid NA 0.00142 no no no up no dn IL-17 signaling pathway MUFA%+blood 0 0 0.475384615 kegg serum_fattyacid NA 0.00142 no no no up no dn Inflammatory mediator regulation of TRP channels MUFA%+blood 0 0 -0.522307692 kegg serum_fattyacid NA 0.00142 no no no up no dn Influenza A MUFA%+blood 0.573684211 0 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Insulin secretion MUFA%+blood 0 0 -0.569230769 yes kegg serum_fattyacid NA 0.00142 no up up up no dn Insulin signaling pathway MUFA%+blood 0 -0.55 0 kegg serum_fattyacid NA 0.00142 no no no up no dn iso-DCA+blood MUFA%+blood 0.496240602 0 0 serum_bileacids serum_fattyacid 0.38 0.00142 no no no up no dn isobutyric acid C4+blood MUFA%+blood 0 0 0.406495726 serum_scfa serum_fattyacid 0.0151 0.00142 up up no up no dn L-Asparagine+blood MUFA%+blood 0 0.575980392 0.452991453 serum_aminoacids serum_fattyacid 0.784 0.00142 no no no up no dn L-Glutamine+blood MUFA%+blood 0 0 0.641709402 serum_aminoacids serum_fattyacid 0.639 0.00142 no no no up no dn L-Histidine+blood MUFA%+blood 0.47518797 0 0.457094017 serum_aminoacids serum_fattyacid 0.109 0.00142 no no no up no dn L-Isoleucine+blood MUFA%+blood 0 0.593137255 0 yes serum_aminoacids serum_fattyacid 5.47E-06 0.00142 up up no up no dn L-Leucine+blood MUFA%+blood 0 0.509803922 0 yes serum_aminoacids serum_fattyacid 3.22E-05 0.00142 up up no up no dn L-Lysine+blood MUFA%+blood 0.547368421 0.62745098 0 yes serum_aminoacids serum_fattyacid 0.0107 0.00142 no up no up no dn L-Methionine+blood MUFA%+blood 0 0.656862745 0 serum_aminoacids serum_fattyacid 0.626 0.00142 no no no up no dn L-Phenylalanine+blood MUFA%+blood 0 0.56127451 0 yes serum_aminoacids serum_fattyacid 0.0103 0.00142 up up no up no dn L-Threonine+blood MUFA%+blood 0 0.634803922 0 serum_aminoacids serum_fattyacid 0.0538 0.00142 dn no up up no dn L-Tryptophan+blood MUFA%+blood 0.44962406 0 0 serum_aminoacids serum_fattyacid 0.164 0.00142 no no no up no dn Lachnospira MUFA%+blood -0.473684211 0 0 butyrate-producing Genus serum_fattyacid 0.279 0.00142 no no no up no dn lauric acid C12+blood MUFA%+blood 0.518796992 0 0 serum_mcfa serum_fattyacid 0.015 0.00142 no dn dn up no dn Legionellosis MUFA%+blood -0.512280702 0 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Lipid and atherosclerosis MUFA%+blood 0.464912281 0.723529412 0.558461538 kegg serum_fattyacid NA 0.00142 no no no up no dn Long-term depression MUFA%+blood 0 0 -0.47 kegg serum_fattyacid NA 0.00142 no no no up no dn Lysosome MUFA%+blood 0 0 0.534615385 kegg serum_fattyacid NA 0.00142 no no no up no dn Melanogenesis MUFA%+blood 0 0 -0.449230769 kegg serum_fattyacid NA 0.00142 no no no up no dn Morphine addiction MUFA%+blood 0 -0.517647059 0 kegg serum_fattyacid NA 0.00142 no up up up no dn mRNA surveillance pathway MUFA%+blood 0 -0.526470588 0 kegg serum_fattyacid NA 0.00142 no no no up no dn mTOR signaling pathway MUFA%+blood 0 -0.605882353 0 kegg serum_fattyacid NA 0.00142 no no no up no dn MUFA+blood MUFA%+blood 0.521804511 0.553921569 0.569230769 serum_fattyacid serum_fattyacid 0.00175 0.00142 up no dn up no dn Neuroactive ligand-receptor interaction MUFA%+blood 0 0.588235294 0.503076923 kegg serum_fattyacid NA 0.00142 up up up up no dn Neutrophil extracellular trap formation MUFA%+blood 0 0.532352941 0.44 kegg serum_fattyacid NA 0.00142 no no no up no dn NOD-like receptor signaling pathway MUFA%+blood 0 0.570588235 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Non-alcoholic fatty liver disease MUFA%+blood 0 0 -0.423076923 kegg serum_fattyacid NA 0.00142 no no no up no dn Olfactory transduction MUFA%+blood 0 0.505882353 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Pancreatic secretion MUFA%+blood 0 0 -0.477692308 kegg serum_fattyacid NA 0.00142 no no no up no dn Pathways in cancer MUFA%+blood 0 0 -0.405384615 kegg serum_fattyacid NA 0.00142 no no no up no dn Peroxisome MUFA%+blood 0 0.579411765 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Pertussis MUFA%+blood 0.498245614 0.647058824 0.420769231 kegg serum_fattyacid NA 0.00142 no no dn up no dn Phospholipase D signaling pathway MUFA%+blood 0 0 -0.42 kegg serum_fattyacid NA 0.00142 no up up up no dn PI3K-Akt signaling pathway MUFA%+blood -0.49122807 0 0 yes kegg serum_fattyacid NA 0.00142 no up up up no dn Platinum drug resistance MUFA%+blood 0 0 -0.421538462 kegg serum_fattyacid NA 0.00142 no no no up no dn Porphyrin and chlorophyll metabolism MUFA%+blood -0.463157895 0 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Prevotella MUFA%+blood -0.536341014 0 0 acetate-producing Genus serum_fattyacid 0.287 0.00142 no no no up no dn Prion disease MUFA%+blood 0 -0.505882353 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Prolactin signaling pathway MUFA%+blood 0.473684211 0 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Propionic acid+stool MUFA%+blood 0 0 -0.563909774 yes stool_scfa serum_fattyacid 0.0436 0.00142 dn no up up no dn Proteasome MUFA%+blood 0 0 0.576923077 kegg serum_fattyacid NA 0.00142 no no no up no dn Protein processing in endoplasmic reticulum MUFA%+blood 0 -0.526470588 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Proteoglycans in cancer MUFA%+blood 0 -0.594117647 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Regulation of lipolysis in adipocytes MUFA%+blood 0 0 -0.409230769 kegg serum_fattyacid NA 0.00142 no no no up no dn Retrograde endocannabinoid signaling MUFA%+blood 0 -0.517647059 0 kegg serum_fattyacid NA 0.00142 no no up up no dn Ribosome MUFA%+blood 0 -0.570588235 0 kegg serum_fattyacid NA 0.00142 no no no up no dn RNA degradation MUFA%+blood 0 -0.532352941 0 kegg serum_fattyacid NA 0.00142 no no no up no dn RNA transport MUFA%+blood -0.50877193 -0.576470588 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Ruminococcus MUFA%+blood 0 0 -0.487807135 Genus serum_fattyacid 0.0679 0.00142 no no dn up no dn Signaling pathways regulating pluripotency of stem cells MUFA%+blood 0 0 -0.42 kegg serum_fattyacid NA 0.00142 no no no up no dn Staphylococcus aureus infection MUFA%+blood 0 0.505882353 0.551538462 kegg serum_fattyacid NA 0.00142 up no no up no dn Systemic lupus erythematosus MUFA%+blood 0 0 0.487692308 kegg serum_fattyacid NA 0.00142 no no no up no dn Thermogenesis MUFA%+blood 0 -0.535294118 0 kegg serum_fattyacid NA 0.00142 no no no up no dn Thyroid hormone synthesis MUFA%+blood 0 -0.5 -0.432307692 kegg serum_fattyacid NA 0.00142 no no no up no dn Tight junction MUFA%+blood 0 0 0.421538462 kegg serum_fattyacid NA 0.00142 no no no up no dn Toll-like receptor signaling pathway MUFA%+blood 0.503508772 0 0 yes kegg serum_fattyacid NA 0.00142 no no no up no dn Tuberculosis MUFA%+blood 0 0.523529412 0.549230769 kegg serum_fattyacid NA 0.00142 no no dn up no dn Vasopressin-regulated water reabsorption MUFA%+blood 0 0 -0.414615385 kegg serum_fattyacid NA 0.00142 no no no up no dn Wnt signaling pathway MUFA%+blood 0 -0.541176471 0 kegg serum_fattyacid NA 0.00142 no no no up no dn 12-ketoDCA+blood MUFA+blood -0.480756345 -0.56642726 0 serum_bileacids serum_fattyacid 0.517 0.00175 no no no up no dn "12,13-EPOME+blood" MUFA+blood 0.468239384 0 0 serum_ARA serum_fattyacid 0.901 0.00175 no no no up no dn 13-HODE+blood MUFA+blood 0.520300752 0 0 serum_ARA serum_fattyacid 0.32 0.00175 no no no up no dn 14:0+blood MUFA+blood 0 0.512254902 0 yes serum_fattyacid serum_fattyacid 0.00572 0.00175 up no dn up no dn 14:1/18:2-PG+blood MUFA+blood -0.487218045 0 0 serum_phospholipids serum_fattyacid 0.00259 0.00175 no up up up no dn 16:0/18:1-PC+blood MUFA+blood 0 0 0.618461538 serum_phospholipids serum_fattyacid 6.15E-07 0.00175 up up up up no dn 16:0/20:4-PE+blood MUFA+blood 0 0 0.425641026 serum_phospholipids serum_fattyacid 0.00139 0.00175 up up no up no dn 16:0/20:5-PG+blood MUFA+blood 0 0 -0.416068376 serum_phospholipids serum_fattyacid 0.00656 0.00175 no up no up no dn 16:0+blood MUFA+blood 0.766917293 0.509803922 0.573333333 yes serum_fattyacid serum_fattyacid 0.00876 0.00175 up no no up no dn 16:1+blood MUFA+blood 0.833082707 0.629901961 0.646495726 yes serum_fattyacid serum_fattyacid 0.0186 0.00175 no no dn up no dn 18:0/16:0-PC+blood MUFA+blood 0 0 0.596581197 serum_phospholipids serum_fattyacid 9.64E-07 0.00175 up up up up no dn 18:0/20:2-PC+blood MUFA+blood 0 -0.544117647 0 serum_phospholipids serum_fattyacid 0.733 0.00175 no no no up no dn 18:0/20:3-PI+blood MUFA+blood 0.532330827 0 0 serum_phospholipids serum_fattyacid 0.377 0.00175 no no no up no dn 18:0/20:4-PI+blood MUFA+blood 0.533834586 0.536764706 0 serum_phospholipids serum_fattyacid 0.167 0.00175 no no no up no dn 18:0+blood MUFA+blood 0.640601504 0 0 serum_fattyacid serum_fattyacid 0.344 0.00175 no no no up no dn 18:1/16:1-PE+blood MUFA+blood 0 0 0.405128205 serum_phospholipids serum_fattyacid 0.000184 0.00175 up up no up no dn 18:1/18:0-PS+blood MUFA+blood 0 0.504901961 0 serum_phospholipids serum_fattyacid 0.193 0.00175 no no no up no dn 18:1/18:1-PE+blood MUFA+blood 0 0 0.454358974 serum_phospholipids serum_fattyacid 1.03E-05 0.00175 up up no up no dn 18:1/18:2-PG+blood MUFA+blood 0 0 -0.507692308 serum_phospholipids serum_fattyacid 5.58E-07 0.00175 no up up up no dn 18:1/20:4-PE+blood MUFA+blood 0 0.492647059 0 serum_phospholipids serum_fattyacid 0.0578 0.00175 up no no up no dn 18:1/20:4-PI+blood MUFA+blood 0 0.674019608 0 serum_phospholipids serum_fattyacid 0.192 0.00175 no no no up no dn 18:1/22:6-PE+blood MUFA+blood 0 0.625 0 serum_phospholipids serum_fattyacid 0.0047 0.00175 no up no up no dn 18:1+blood MUFA+blood 0.995488722 0.990196078 0.98974359 yes serum_fattyacid serum_fattyacid 0.00202 0.00175 up no dn up no dn 18:2n6c+blood MUFA+blood 0.544360902 0 0 serum_fattyacid serum_fattyacid 0.15 0.00175 no no no up no dn 18:3-LPC+blood MUFA+blood 0 0 -0.448888889 serum_phospholipids serum_fattyacid 0.147 0.00175 no no no up no dn 18:3n3+blood MUFA+blood 0.515789474 0 0 serum_fattyacid serum_fattyacid 0.291 0.00175 no no no up no dn 20:1+blood MUFA+blood 0 0.49754902 0 yes serum_fattyacid serum_fattyacid 2.56E-05 0.00175 dn dn dn up no dn 20:2/18:3-PE+blood MUFA+blood 0 0.634803922 0 serum_phospholipids serum_fattyacid 0.0391 0.00175 up up no up no dn 20:3-LPE+blood MUFA+blood 0.446616541 0 0 serum_phospholipids serum_fattyacid 0.084 0.00175 no up no up no dn 20:3/18:0-PI+blood MUFA+blood 0.484210526 0 0 serum_phospholipids serum_fattyacid 0.289 0.00175 no no no up no dn 20:4-LPC+blood MUFA+blood 0 0 -0.419487179 serum_phospholipids serum_fattyacid 0.949 0.00175 no no no up no dn 20:4/18:0-PE+blood MUFA+blood 0 0.492647059 0 serum_phospholipids serum_fattyacid 0.000755 0.00175 up up no up no dn 24:1+blood MUFA+blood 0 0.612745098 0 serum_fattyacid serum_fattyacid 0.00582 0.00175 no dn dn up no dn AA+blood MUFA+blood 0.454135338 0 0 serum_ARA serum_fattyacid 0.212 0.00175 no no no up no dn AGE-RAGE signaling pathway in diabetic complications MUFA+blood 0.615789474 0 0 kegg serum_fattyacid NA 0.00175 no no no up no dn Alcoholism MUFA+blood 0 0.564705882 0 kegg serum_fattyacid NA 0.00175 no no no up no dn AMPK signaling pathway MUFA+blood -0.461403509 0 0 kegg serum_fattyacid NA 0.00175 no no no up no dn Antigen processing and presentation MUFA+blood 0 0 0.492307692 kegg serum_fattyacid NA 0.00175 no no no up no dn Arginine and proline metabolism MUFA+blood 0 0 0.49 kegg serum_fattyacid NA 0.00175 no up no up no dn Bifidobacterium MUFA+blood 0 -0.505211622 0 acetate-producing Genus serum_fattyacid 0.105 0.00175 no dn no up no dn Biosynthesis of amino acids MUFA+blood 0 0 0.421538462 kegg serum_fattyacid NA 0.00175 no no no up no dn Biosynthesis of cofactors MUFA+blood -0.68245614 0 0 kegg serum_fattyacid NA 0.00175 no no no up no dn CA+blood MUFA+blood -0.445280212 0 0 serum_bileacids serum_fattyacid 0.606 0.00175 no no no up no dn Calcium signaling pathway MUFA+blood 0 -0.611764706 0 kegg serum_fattyacid NA 0.00175 no up up up no dn Carbon metabolism MUFA+blood 0 0 0.440769231 kegg serum_fattyacid NA 0.00175 no no no up no dn CDCA+blood MUFA+blood 0 0 -0.45982906 serum_bileacids serum_fattyacid 0.506 0.00175 no no no up no dn Cell adhesion molecules MUFA+blood 0 0 0.416153846 kegg serum_fattyacid NA 0.00175 no no no up no dn cGMP-PKG signaling pathway MUFA+blood 0.607017544 0 0 kegg serum_fattyacid NA 0.00175 no no no up no dn Cholinergic synapse MUFA+blood 0.538596491 0 0 kegg serum_fattyacid NA 0.00175 no no no up no dn Cushing syndrome MUFA+blood 0 0 -0.414615385 kegg serum_fattyacid NA 0.00175 no no up up no dn Cysteine+blood MUFA+blood 0 0 0.448888889 yes serum_aminoacids serum_fattyacid 1.81E-07 0.00175 dn up up up no dn d18:0-24:1-SM+blood MUFA+blood 0 -0.536764706 0 serum_phospholipids serum_fattyacid 0.0609 0.00175 no dn dn up no dn d18:1-22:0-SM+blood MUFA+blood 0 -0.566176471 0 serum_phospholipids serum_fattyacid 0.522 0.00175 no no no up no dn Endocytosis MUFA+blood 0 0 0.410769231 kegg serum_fattyacid NA 0.00175 no no no up no dn Epithelial cell signaling in Helicobacter pylori infection MUFA+blood 0 0 0.457692308 kegg serum_fattyacid NA 0.00175 no no no up no dn Epstein-Barr virus infection MUFA+blood 0 0 0.41 kegg serum_fattyacid NA 0.00175 no no no up no dn Fc gamma R-mediated phagocytosis MUFA+blood 0 0 0.526153846 kegg serum_fattyacid NA 0.00175 no no no up no dn FoxO signaling pathway MUFA+blood 0 0.502941176 0 kegg serum_fattyacid NA 0.00175 no no no up no dn GABAergic synapse MUFA+blood 0.561403509 0 0 kegg serum_fattyacid NA 0.00175 no up up up no dn Gastric cancer MUFA+blood 0 0 -0.417692308 kegg serum_fattyacid NA 0.00175 no no no up no dn GLCA+blood MUFA+blood 0 -0.516353281 0 serum_bileacids serum_fattyacid 0.319 0.00175 no no no up no dn Glioma MUFA+blood 0.621052632 0.573529412 0 kegg serum_fattyacid NA 0.00175 no no no up no dn "Glycine, serine and threonine metabolism" MUFA+blood -0.594736842 0 0 kegg serum_fattyacid NA 0.00175 no up no up no dn HCA+blood MUFA+blood -0.477756755 0 -0.47474693 serum_bileacids serum_fattyacid 0.544 0.00175 no no no up no dn HCA+stool MUFA+blood 0.604395604 0 0 stool_bileacids serum_fattyacid 0.155 0.00175 no no no up no dn Human immunodeficiency virus 1 infection MUFA+blood 0 0 0.441538462 kegg serum_fattyacid NA 0.00175 no no no up no dn Human T-cell leukemia virus 1 infection MUFA+blood 0 0 0.453076923 kegg serum_fattyacid NA 0.00175 no no no up no dn IL-17 signaling pathway MUFA+blood 0 0 0.428461538 kegg serum_fattyacid NA 0.00175 no no no up no dn Inflammatory bowel disease MUFA+blood 0.510526316 0 0 kegg serum_fattyacid NA 0.00175 no no no up no dn L-Leucine+blood MUFA+blood -0.521804511 0 0 yes serum_aminoacids serum_fattyacid 3.22E-05 0.00175 up up no up no dn L-Proline+blood MUFA+blood -0.560902256 0 -0.506324786 yes serum_aminoacids serum_fattyacid 0.00265 0.00175 up up no up no dn Leishmaniasis MUFA+blood 0 0 0.506153846 kegg serum_fattyacid NA 0.00175 no no no up no dn Lipid and atherosclerosis MUFA+blood 0.670175439 0 0.610769231 kegg serum_fattyacid NA 0.00175 no no no up no dn Long-term potentiation MUFA+blood 0.492982456 0 0 kegg serum_fattyacid NA 0.00175 no no up up no dn Mineral absorption MUFA+blood 0 -0.529411765 0 kegg serum_fattyacid NA 0.00175 no no no up no dn Mitophagy - animal MUFA+blood 0 -0.541176471 0 kegg serum_fattyacid NA 0.00175 no no no up no dn Nicotinate and nicotinamide metabolism MUFA+blood 0 0.520588235 0 kegg serum_fattyacid NA 0.00175 no no no up no dn NOD-like receptor signaling pathway MUFA+blood 0.559649123 0 0 kegg serum_fattyacid NA 0.00175 no no no up no dn Olfactory transduction MUFA+blood 0.522807018 0 0 kegg serum_fattyacid NA 0.00175 no no no up no dn Osteoclast differentiation MUFA+blood 0 0 0.47 kegg serum_fattyacid NA 0.00175 no no no up no dn Peroxisome MUFA+blood 0.471929825 0 0 kegg serum_fattyacid NA 0.00175 no no no up no dn Pertussis MUFA+blood 0.598245614 0 0.493076923 kegg serum_fattyacid NA 0.00175 no no dn up no dn Phagosome MUFA+blood 0 0 0.487692308 kegg serum_fattyacid NA 0.00175 no no no up no dn Porphyrin and chlorophyll metabolism MUFA+blood -0.598245614 -0.505882353 0 kegg serum_fattyacid NA 0.00175 no no no up no dn PPAR signaling pathway MUFA+blood 0 0 0.482307692 kegg serum_fattyacid NA 0.00175 no no no up no dn Prolactin signaling pathway MUFA+blood 0.489473684 0 0 kegg serum_fattyacid NA 0.00175 no no no up no dn Proteoglycans in cancer MUFA+blood -0.622807018 -0.576470588 0 kegg serum_fattyacid NA 0.00175 no no no up no dn Ras signaling pathway MUFA+blood 0 0 -0.401538462 yes kegg serum_fattyacid NA 0.00175 no up up up no dn Salivary secretion MUFA+blood 0 0.523529412 0 kegg serum_fattyacid NA 0.00175 no no no up no dn Shigellosis MUFA+blood -0.528070175 0 0 kegg serum_fattyacid NA 0.00175 no no no up no dn Sphingolipid signaling pathway MUFA+blood 0.585964912 0 0 kegg serum_fattyacid NA 0.00175 no no no up no dn Staphylococcus aureus infection MUFA+blood 0 0 0.603846154 kegg serum_fattyacid NA 0.00175 up no no up no dn Systemic lupus erythematosus MUFA+blood 0 0 0.581538462 kegg serum_fattyacid NA 0.00175 no no no up no dn Toll-like receptor signaling pathway MUFA+blood 0 0 0.427692308 yes kegg serum_fattyacid NA 0.00175 no no no up no dn Toxoplasmosis MUFA+blood 0 0 0.496153846 kegg serum_fattyacid NA 0.00175 no no no up no dn Tuberculosis MUFA+blood 0.477192982 0 0.473076923 kegg serum_fattyacid NA 0.00175 no no dn up no dn Ubiquitin mediated proteolysis MUFA+blood -0.468421053 -0.520588235 0 kegg serum_fattyacid NA 0.00175 no no no up no dn VEGF signaling pathway MUFA+blood 0.547368421 0 0 kegg serum_fattyacid NA 0.00175 no no no up no dn "Alanine, aspartate and glutamate metabolism" N-Glycan biosynthesis 0 -0.839920949 -0.486486486 kegg kegg NA NA no no no no no no Arginine and proline metabolism N-Glycan biosynthesis -0.615652174 -0.802371542 -0.552638353 kegg kegg NA NA no up no no no no Arginine biosynthesis N-Glycan biosynthesis -0.423478261 -0.862648221 -0.606949807 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism N-Glycan biosynthesis 0 0.541501976 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) N-Glycan biosynthesis 0 0.747035573 0.543629344 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism N-Glycan biosynthesis 0.413043478 0.68972332 0.565765766 kegg kegg NA NA no no no no no no Fatty acid biosynthesis N-Glycan biosynthesis 0 -0.831027668 0 kegg kegg NA NA no no no no no no Fatty acid degradation N-Glycan biosynthesis 0 -0.517786561 0 kegg kegg NA NA no no no no no no Galactose metabolism N-Glycan biosynthesis 0 -0.461462451 0 kegg kegg NA NA no no no no no no Glutathione metabolism N-Glycan biosynthesis 0 0.527667984 -0.406435006 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis N-Glycan biosynthesis 0 0.446640316 0 kegg kegg NA NA no no no no no no Lysine degradation N-Glycan biosynthesis 0.475652174 0.479249012 0.641956242 kegg kegg NA NA no no no no no no Oxidative phosphorylation N-Glycan biosynthesis 0 0.551383399 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions N-Glycan biosynthesis 0 0.87055336 0.527670528 kegg kegg NA NA no no no no no no Pentose phosphate pathway N-Glycan biosynthesis -0.606956522 -0.712450593 -0.682110682 kegg kegg NA NA no no no no no no Phenylalanine metabolism N-Glycan biosynthesis 0 0.678853755 0 kegg kegg NA NA no no no no no no Purine metabolism N-Glycan biosynthesis 0 0.445652174 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism N-Glycan biosynthesis 0 0.685770751 0 kegg kegg NA NA no no no no no no Selenocompound metabolism N-Glycan biosynthesis 0.513913043 0 0.645302445 kegg kegg NA NA no no no no no no Starch and sucrose metabolism N-Glycan biosynthesis -0.515652174 -0.780632411 -0.422136422 kegg kegg NA NA no no no no no no Steroid biosynthesis N-Glycan biosynthesis 0.713043478 0.516798419 0.482625483 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis N-Glycan biosynthesis 0 0.461462451 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies N-Glycan biosynthesis 0.476521739 0.663043478 0.581467181 kegg kegg NA NA no no no no no no Tryptophan metabolism N-Glycan biosynthesis 0 0.509881423 0 kegg kegg NA NA no up no no no no Tyrosine metabolism N-Glycan biosynthesis 0 0.62055336 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis N-Glycan biosynthesis 0 0.66798419 0.584555985 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" N-Glycan biosynthesis 0 0.755928854 0.472586873 kegg kegg NA NA no no no no no no 14:0/18:0-PC+blood n3+blood 0 -0.556372549 0 serum_phospholipids serum_fattyacid 0.00289 0.806 up up no no no no 14:0/18:2-PC+blood n3+blood 0.54887218 0 0 serum_phospholipids serum_fattyacid 0.102 0.806 no up no no no no 14:0/20:4-PC+blood n3+blood 0.536842105 0 0 serum_phospholipids serum_fattyacid 0.486 0.806 no no no no no no 14:0+blood n3+blood 0.497744361 0 0 yes serum_fattyacid serum_fattyacid 0.00572 0.806 up no dn no no no 16:0-LPE+blood n3+blood 0 0 -0.418119658 serum_phospholipids serum_fattyacid 0.0711 0.806 up up no no no no 16:0/16:0-PI+blood n3+blood 0 -0.632352941 0 serum_phospholipids serum_fattyacid 0.358 0.806 no no no no no no 16:0/16:1-PC+blood n3+blood 0 -0.512254902 0 serum_phospholipids serum_fattyacid 0.00283 0.806 up up no no no no 16:0/16:1-PI+blood n3+blood 0 -0.50245098 0 serum_phospholipids serum_fattyacid 0.262 0.806 no no no no no no 16:0/18:0-PS+blood n3+blood 0 0.620098039 0 serum_phospholipids serum_fattyacid 0.377 0.806 no no no no no no 16:0/20:5-PC+blood n3+blood 0.693233083 0.720588235 0.462564103 serum_phospholipids serum_fattyacid 0.628 0.806 no no no no no no 16:0/22:0-PE+blood n3+blood 0.505263158 0.610294118 0 serum_phospholipids serum_fattyacid 0.00839 0.806 dn no up no no no 16:0/22:6-PC+blood n3+blood 0.592481203 0.796568627 0.652649573 serum_phospholipids serum_fattyacid 4.53E-05 0.806 no up up no no no 16:1/16:0-PC+blood n3+blood 0 0.598039216 0 serum_phospholipids serum_fattyacid 0.0215 0.806 no up up no no no 16:1/16:1-PC+blood n3+blood 0 0.524509804 0 serum_phospholipids serum_fattyacid 0.0177 0.806 no no up no no no 18:0-LPE+blood n3+blood 0 0 -0.410598291 serum_phospholipids serum_fattyacid 0.491 0.806 no no no no no no 18:0/18:0-PS+blood n3+blood 0 0.551470588 0 serum_phospholipids serum_fattyacid 0.00617 0.806 no up no no no no 18:0/20:4-PC+blood n3+blood 0 0.651960784 0 serum_phospholipids serum_fattyacid 0.454 0.806 no no no no no no 18:0/20:4-PI+blood n3+blood 0 0.56127451 0 serum_phospholipids serum_fattyacid 0.167 0.806 no no no no no no 18:0/20:5-PC+blood n3+blood 0 0.647058824 0 serum_phospholipids serum_fattyacid 0.17 0.806 no no no no no no 18:0/22:6-PC+blood n3+blood 0.682706767 0.781862745 0.69982906 serum_phospholipids serum_fattyacid 0.0775 0.806 no no up no no no 18:0/22:6-PE+blood n3+blood 0 0.723039216 0 serum_phospholipids serum_fattyacid 0.00022 0.806 up up no no no no 18:0/22:6-PI+blood n3+blood 0.684210526 0.732843137 0.613675214 serum_phospholipids serum_fattyacid 0.425 0.806 no no no no no no 18:1-LPC+blood n3+blood -0.512781955 0 0 serum_phospholipids serum_fattyacid 0.179 0.806 no no no no no no 18:1-LPE+blood n3+blood 0 -0.507352941 -0.44957265 serum_phospholipids serum_fattyacid 0.117 0.806 no no no no no no 18:1/16:0-PI+blood n3+blood 0 -0.553921569 0 serum_phospholipids serum_fattyacid 0.793 0.806 no no no no no no 18:1/18:0-PS+blood n3+blood 0 0.607843137 0 serum_phospholipids serum_fattyacid 0.193 0.806 no no no no no no 18:1/20:3-PC+blood n3+blood 0 -0.553921569 0 serum_phospholipids serum_fattyacid 0.00872 0.806 no up up no no no 18:1/20:4-PC+blood n3+blood 0 0.615196078 0 serum_phospholipids serum_fattyacid 0.582 0.806 no no no no no no 18:1/22:6-PE+blood n3+blood 0 0.649509804 0.405128205 serum_phospholipids serum_fattyacid 0.0047 0.806 no up no no no no 18:2-LPE+blood n3+blood 0 -0.575980392 0 serum_phospholipids serum_fattyacid 0.112 0.806 no no no no no no 18:2/18:1-PC+blood n3+blood -0.454135338 0 0 serum_phospholipids serum_fattyacid 2.30E-05 0.806 dn up up no no no 18:3n3+blood n3+blood 0 0.566176471 0 serum_fattyacid serum_fattyacid 0.291 0.806 no no no no no no 20:0/20:4-PE+blood n3+blood 0 0 -0.567179487 serum_phospholipids serum_fattyacid 0.00128 0.806 up up no no no no 20:0+blood n3+blood -0.541353383 0 0 yes serum_fattyacid serum_fattyacid 0.000278 0.806 dn no up no no no 20:1/20:4-PC+blood n3+blood 0.563909774 0.580882353 0.613675214 serum_phospholipids serum_fattyacid 0.0419 0.806 no no up no no no 20:1/20:4-PE+blood n3+blood 0 0 -0.405811966 serum_phospholipids serum_fattyacid 0.0042 0.806 up up no no no no 20:2-LPC+blood n3+blood -0.55037594 0 0 serum_phospholipids serum_fattyacid 0.119 0.806 no no up no no no 20:2/18:0-PC+blood n3+blood 0.479699248 0 0 serum_phospholipids serum_fattyacid 0.0427 0.806 no up no no no no 20:3-LPC+blood n3+blood 0 -0.620098039 -0.470769231 serum_phospholipids serum_fattyacid 0.0292 0.806 no up no no no no 20:3-LPE+blood n3+blood 0 -0.691176471 -0.597264957 serum_phospholipids serum_fattyacid 0.084 0.806 no up no no no no 20:3/16:0-PC+blood n3+blood -0.464661654 0 0 serum_phospholipids serum_fattyacid 0.00405 0.806 no up up no no no 20:3/18:0-PC+blood n3+blood 0.446616541 0 0 serum_phospholipids serum_fattyacid 0.296 0.806 no no no no no no 20:3/18:0-PI+blood n3+blood 0 0.514705882 0 serum_phospholipids serum_fattyacid 0.289 0.806 no no no no no no 20:4-LPE+blood n3+blood 0 0 -0.497435897 serum_phospholipids serum_fattyacid 0.552 0.806 no no no no no no 20:4n6+blood n3+blood 0 0.632352941 0 serum_fattyacid serum_fattyacid 0.133 0.806 no no no no no no 20:5-LPC+blood n3+blood 0.633082707 0.639705882 0.574700855 serum_phospholipids serum_fattyacid 0.558 0.806 no no no no no no 20:5/18:0-PC+blood n3+blood 0.511278195 0.718137255 0.545982906 serum_phospholipids serum_fattyacid 3.97E-06 0.806 no up up no no no 20:5n3+blood n3+blood 0.730827068 0.816176471 0.579487179 serum_fattyacid serum_fattyacid 0.988 0.806 no no no no no no 22:0/16:0-PE+blood n3+blood 0.72481203 0.556372549 0 serum_phospholipids serum_fattyacid 0.091 0.806 no no up no no no 22:6-LPC+blood n3+blood 0.54887218 0.718137255 0.787350427 serum_phospholipids serum_fattyacid 0.127 0.806 no no up no no no 22:6n3+blood n3+blood 0.921804511 0.946078431 0.915897436 serum_fattyacid serum_fattyacid 0.792 0.806 no no no no no no 5-HETE+blood n3+blood 0 0 0.429848155 serum_ARA serum_fattyacid 0.697 0.806 no no no no no no acetic acid C2+blood n3+blood 0.485714286 0 0 serum_scfa serum_fattyacid 0.000193 0.806 up dn no no no no Amyotrophic lateral sclerosis n3+blood -0.468421053 0 0 kegg serum_fattyacid NA 0.806 no no no no no no Bacteroides n3+blood 0 0 0.429059829 LPS-producing Genus serum_fattyacid 0.000267 0.806 dn dn up no no no Calcium signaling pathway n3+blood 0 -0.591176471 0 kegg serum_fattyacid NA 0.806 no up up no no no cAMP signaling pathway n3+blood 0 -0.532352941 0 yes kegg serum_fattyacid NA 0.806 no up up no no no Choline+blood n3+blood -0.460150376 0 0 serum_choline serum_fattyacid 0.0395 0.806 no up no no no no Cholinergic synapse n3+blood 0 0.629411765 0 kegg serum_fattyacid NA 0.806 no no no no no no Coronavirus disease - COVID-19 n3+blood -0.503508772 0 0 kegg serum_fattyacid NA 0.806 no no no no no no Cytosolic DNA-sensing pathway n3+blood 0 -0.523529412 0 kegg serum_fattyacid NA 0.806 no no no no no no d18:0-16:0-SM+blood n3+blood 0 0 -0.425641026 serum_phospholipids serum_fattyacid 0.202 0.806 no no no no no no d18:1-16:0-SM+blood n3+blood 0 0 -0.476239316 serum_phospholipids serum_fattyacid 0.14 0.806 no no no no no no d18:1-16:1-SM+blood n3+blood 0 0 -0.401709402 serum_phospholipids serum_fattyacid 0.2 0.806 no no no no no no d18:1-18:0-SM+blood n3+blood 0 0.512254902 0 serum_phospholipids serum_fattyacid 0.97 0.806 no no no no no no decanoic acid C10+blood n3+blood 0 -0.68872549 0 serum_mcfa serum_fattyacid 6.64E-11 0.806 dn dn no no no no DMG+blood n3+blood 0 -0.556372549 0 serum_choline serum_fattyacid 0.909 0.806 no no no no no no EPA+blood n3+blood 0.663157895 0.74754902 0.534358974 serum_ARA serum_fattyacid 0.212 0.806 no no no no no no HDCA+stool n3+blood -0.554945055 0 0 stool_bileacids serum_fattyacid 0.176 0.806 no no no no no no Hepatitis C n3+blood 0 -0.555882353 0 kegg serum_fattyacid NA 0.806 no no no no no no Hypotaurine+blood n3+blood -0.595488722 0 0 serum_aminoacids serum_fattyacid 0.933 0.806 no no no no no no iso-LCA+blood n3+blood -0.616981919 0 0 serum_bileacids serum_fattyacid 0.507 0.806 no no no no no no isocapric acid iso-C6+blood n3+blood 0 0 -0.513846154 serum_scfa serum_fattyacid 0.0458 0.806 no no dn no no no isovaleric acid iso-C5+blood n3+blood 0 0.509803922 0 serum_scfa serum_fattyacid 0.117 0.806 no no no no no no Kaposi sarcoma-associated herpesvirus infection n3+blood 0 -0.711764706 0 kegg serum_fattyacid NA 0.806 no no dn no no no L-Aspartic acid+blood n3+blood 0 0 0.47008547 yes serum_aminoacids serum_fattyacid 0.0226 0.806 up up no no no no L-Histidine+blood n3+blood 0 -0.56127451 0 serum_aminoacids serum_fattyacid 0.109 0.806 no no no no no no L-Isoleucine+blood n3+blood 0 0 0.419487179 yes serum_aminoacids serum_fattyacid 5.47E-06 0.806 up up no no no no L-Phenylalanine+blood n3+blood 0 0 0.448205128 yes serum_aminoacids serum_fattyacid 0.0103 0.806 up up no no no no L-Phenylalanine+stool n3+blood 0 0 0.455639098 stool_cometabolism serum_fattyacid 0.398 0.806 no no no no no no L-Tryptophan+stool n3+blood 0 0 0.472180451 stool_cometabolism serum_fattyacid 0.557 0.806 no no no no no no LCA+blood n3+blood -0.524595303 0 0 serum_bileacids serum_fattyacid 0.884 0.806 no no no no no no Malaria n3+blood 0 -0.529411765 0 kegg serum_fattyacid NA 0.806 no no no no no no MAPK signaling pathway n3+blood 0 0.579411765 0 kegg serum_fattyacid NA 0.806 no no no no no no Methanobrevibacter n3+blood 0 0 0.413664024 Genus serum_fattyacid 0.629 0.806 no no no no no no Mineral absorption n3+blood 0 -0.647058824 0 kegg serum_fattyacid NA 0.806 no no no no no no Mitophagy - animal n3+blood 0 -0.605882353 0 kegg serum_fattyacid NA 0.806 no no no no no no Necroptosis n3+blood 0 -0.617647059 0 kegg serum_fattyacid NA 0.806 no no no no no no nutriCA+stool n3+blood 0 0 -0.448120301 stool_bileacids serum_fattyacid 0.481 0.806 no no no no no no Oxidative phosphorylation n3+blood -0.459649123 0 0 kegg serum_fattyacid NA 0.806 no no no no no no Parkinson disease n3+blood -0.461403509 0 0 kegg serum_fattyacid NA 0.806 no no no no no no Pathways of neurodegeneration - multiple diseases n3+blood -0.471929825 0 0 kegg serum_fattyacid NA 0.806 no no no no no no Pertussis n3+blood 0.49122807 0 0 kegg serum_fattyacid NA 0.806 no no dn no no no Renal cell carcinoma n3+blood 0 -0.526470588 0 kegg serum_fattyacid NA 0.806 no no no no no no Ribosome n3+blood -0.503508772 0 0 kegg serum_fattyacid NA 0.806 no no no no no no Ruminococcus n3+blood 0 -0.487745098 0 acetate-producing Genus serum_fattyacid 0.335 0.806 no no no no no no Shigellosis n3+blood -0.468421053 -0.688235294 0 kegg serum_fattyacid NA 0.806 no no no no no no Thermogenesis n3+blood -0.524561404 0 0 kegg serum_fattyacid NA 0.806 no no no no no no Ubiquitin mediated proteolysis n3+blood 0 -0.544117647 0 kegg serum_fattyacid NA 0.806 no no no no no no "12,13-EPOME+blood" n6/n3+blood 0 0 -0.448773013 serum_ARA serum_fattyacid 0.901 0.226 no no no no no no 13-HODE+blood n6/n3+blood 0.508270677 0.509803922 0 serum_ARA serum_fattyacid 0.32 0.226 no no no no no no 14:0/18:2-PC+blood n6/n3+blood -0.538345865 0 0 serum_phospholipids serum_fattyacid 0.102 0.226 no up no no no no 14:0/20:4-PC+blood n6/n3+blood -0.538345865 0 0 serum_phospholipids serum_fattyacid 0.486 0.226 no no no no no no 16:0/14:0-PC+blood n6/n3+blood 0.508270677 0 0 serum_phospholipids serum_fattyacid 0.0206 0.226 no up up no no no 16:0/16:0-PI+blood n6/n3+blood -0.472180451 0 0 serum_phospholipids serum_fattyacid 0.358 0.226 no no no no no no 16:0/16:1-PI+blood n6/n3+blood -0.512781955 0 0 serum_phospholipids serum_fattyacid 0.262 0.226 no no no no no no 16:0/18:0-PS+blood n6/n3+blood 0 -0.68627451 0 serum_phospholipids serum_fattyacid 0.377 0.226 no no no no no no 16:0/18:1-PC+blood n6/n3+blood 0.457142857 0 0 serum_phospholipids serum_fattyacid 6.15E-07 0.226 up up up no no no 16:0/20:3-PC+blood n6/n3+blood 0 0 0.658119658 serum_phospholipids serum_fattyacid 5.43E-06 0.226 no up up no no no 16:0/20:4-PC+blood n6/n3+blood 0.55037594 0 0 serum_phospholipids serum_fattyacid 0.0262 0.226 no up no no no no 16:0/20:4-PI+blood n6/n3+blood -0.487218045 0 0 serum_phospholipids serum_fattyacid 0.558 0.226 no no no no no no 16:0/20:5-PC+blood n6/n3+blood -0.77443609 -0.769607843 -0.764786325 serum_phospholipids serum_fattyacid 0.628 0.226 no no no no no no 16:0/20:5-PG+blood n6/n3+blood 0.577443609 0 0 serum_phospholipids serum_fattyacid 0.00656 0.226 no up no no no no 16:0/22:0-PE+blood n6/n3+blood 0 -0.56372549 0 serum_phospholipids serum_fattyacid 0.00839 0.226 dn no up no no no 16:0/22:6-PC+blood n6/n3+blood 0 -0.573529412 0 serum_phospholipids serum_fattyacid 4.53E-05 0.226 no up up no no no 16:0/22:6-PE+blood n6/n3+blood 0 -0.524509804 0 serum_phospholipids serum_fattyacid 0.000934 0.226 up up no no no no 16:1/18:1-PG+blood n6/n3+blood 0.547368421 0 0 serum_phospholipids serum_fattyacid 3.21E-05 0.226 no up up no no no 16:1/18:2-PG+blood n6/n3+blood 0.685714286 0 0 serum_phospholipids serum_fattyacid 1.40E-08 0.226 no up up no no no 18:0/18:0-PE+blood n6/n3+blood -0.473684211 0 0 serum_phospholipids serum_fattyacid 0.00896 0.226 up up no no no no 18:0/18:0-PS+blood n6/n3+blood 0 -0.708333333 -0.408547009 serum_phospholipids serum_fattyacid 0.00617 0.226 no up no no no no 18:0/18:1-PE+blood n6/n3+blood -0.472180451 0 0 serum_phospholipids serum_fattyacid 0.00716 0.226 up up no no no no 18:0/20:3-PI+blood n6/n3+blood 0.506766917 0 0 serum_phospholipids serum_fattyacid 0.377 0.226 no no no no no no 18:0/20:4-PI+blood n6/n3+blood 0.47518797 0 0 serum_phospholipids serum_fattyacid 0.167 0.226 no no no no no no 18:0/22:6-PA+blood n6/n3+blood 0 -0.49754902 0 serum_phospholipids serum_fattyacid 0.22 0.226 no no no no no no 18:0/22:6-PC+blood n6/n3+blood 0 -0.823529412 -0.541196581 serum_phospholipids serum_fattyacid 0.0775 0.226 no no up no no no 18:0/22:6-PE+blood n6/n3+blood 0 -0.740196078 0 serum_phospholipids serum_fattyacid 0.00022 0.226 up up no no no no 18:0/22:6-PI+blood n6/n3+blood -0.529323308 -0.759803922 -0.513162393 serum_phospholipids serum_fattyacid 0.425 0.226 no no no no no no 18:1-LPC+blood n6/n3+blood 0.727819549 0 0 serum_phospholipids serum_fattyacid 0.179 0.226 no no no no no no 18:1-LPE+blood n6/n3+blood 0 0.487745098 0 serum_phospholipids serum_fattyacid 0.117 0.226 no no no no no no 18:1/18:1-PC+blood n6/n3+blood 0.478195489 0 0.667692308 serum_phospholipids serum_fattyacid 1.34E-05 0.226 no up up no no no 18:1/18:2-PG+blood n6/n3+blood 0.642105263 0 0 serum_phospholipids serum_fattyacid 5.58E-07 0.226 no up up no no no 18:1/20:3-PC+blood n6/n3+blood 0 0.517156863 0.617777778 serum_phospholipids serum_fattyacid 0.00872 0.226 no up up no no no 18:1/20:4-PC+blood n6/n3+blood 0 -0.504901961 0 serum_phospholipids serum_fattyacid 0.582 0.226 no no no no no no 18:2-LPA+blood n6/n3+blood 0 0.600490196 0 serum_phospholipids serum_fattyacid 0.00684 0.226 dn no up no no no 18:2-LPC+blood n6/n3+blood 0.511278195 0 0 serum_phospholipids serum_fattyacid 0.00743 0.226 dn no up no no no 18:2-LPE+blood n6/n3+blood 0 0.723039216 0 serum_phospholipids serum_fattyacid 0.112 0.226 no no no no no no 18:2/16:0-PC+blood n6/n3+blood 0.445112782 0 0 serum_phospholipids serum_fattyacid 8.67E-05 0.226 no up up no no no 18:2/18:1-PC+blood n6/n3+blood 0.554887218 0 0.407179487 serum_phospholipids serum_fattyacid 2.30E-05 0.226 dn up up no no no 18:2/18:2-PC+blood n6/n3+blood 0.473684211 0 0 serum_phospholipids serum_fattyacid 1.98E-05 0.226 dn up up no no no 20:0/20:4-PE+blood n6/n3+blood 0 0 0.418803419 serum_phospholipids serum_fattyacid 0.00128 0.226 up up no no no no 20:0/20:5-PC+blood n6/n3+blood 0 -0.691176471 0 serum_phospholipids serum_fattyacid 0.882 0.226 no no no no no no 20:0+blood n6/n3+blood 0.467669173 0 0 yes serum_fattyacid serum_fattyacid 0.000278 0.226 dn no up no no no 20:1/20:4-PC+blood n6/n3+blood 0 -0.578431373 0 serum_phospholipids serum_fattyacid 0.0419 0.226 no no up no no no 20:2-LPC+blood n6/n3+blood 0.67518797 0 0.456410256 serum_phospholipids serum_fattyacid 0.119 0.226 no no up no no no 20:2/18:0-PC+blood n6/n3+blood -0.463157895 0 0 serum_phospholipids serum_fattyacid 0.0427 0.226 no up no no no no 20:2+blood n6/n3+blood 0.455639098 0.654411765 0 serum_fattyacid serum_fattyacid 0.478 0.226 no no no no no no 20:3-LPE+blood n6/n3+blood 0 0.56127451 0.503589744 serum_phospholipids serum_fattyacid 0.084 0.226 no up no no no no 20:3/16:0-PC+blood n6/n3+blood 0.633082707 0 0 serum_phospholipids serum_fattyacid 0.00405 0.226 no up up no no no 20:3/18:0-PI+blood n6/n3+blood 0.47518797 0 0 serum_phospholipids serum_fattyacid 0.289 0.226 no no no no no no 20:4-LPE+blood n6/n3+blood 0 0 0.415384615 serum_phospholipids serum_fattyacid 0.552 0.226 no no no no no no 20:5-LPC+blood n6/n3+blood -0.735338346 -0.536764706 -0.790769231 serum_phospholipids serum_fattyacid 0.558 0.226 no no no no no no 20:5n3+blood n6/n3+blood -0.816541353 -0.772058824 -0.825641026 serum_fattyacid serum_fattyacid 0.988 0.226 no no no no no no 22:0/16:0-PE+blood n6/n3+blood -0.446616541 0 0 serum_phospholipids serum_fattyacid 0.091 0.226 no no up no no no 22:6-LPC+blood n6/n3+blood 0 -0.62254902 -0.652649573 serum_phospholipids serum_fattyacid 0.127 0.226 no no up no no no 22:6n3+blood n6/n3+blood -0.790977444 -0.742647059 -0.673162393 serum_fattyacid serum_fattyacid 0.792 0.226 no no no no no no 5-HETE+blood n6/n3+blood 0 0 -0.604120193 serum_ARA serum_fattyacid 0.697 0.226 no no no no no no Adipocytokine signaling pathway n6/n3+blood 0 0.517647059 0 kegg serum_fattyacid NA 0.226 no no no no no no Bacteroides n6/n3+blood 0 -0.661764706 0 LPS-producing Genus serum_fattyacid 0.000267 0.226 dn dn up no no no Betaine+blood n6/n3+blood 0.554887218 0 0 serum_choline serum_fattyacid 0.857 0.226 no no no no no no cAMP signaling pathway n6/n3+blood 0 0.717647059 0 yes kegg serum_fattyacid NA 0.226 no up up no no no Chagas disease n6/n3+blood 0 0.514705882 0 kegg serum_fattyacid NA 0.226 no no no no no no Choline+blood n6/n3+blood 0.521804511 0.647058824 0 serum_choline serum_fattyacid 0.0395 0.226 no up no no no no Cholinergic synapse n6/n3+blood 0 -0.588235294 0 kegg serum_fattyacid NA 0.226 no no no no no no Coprococcus n6/n3+blood -0.568421053 0 0 butyrate-producing Genus serum_fattyacid 0.612 0.226 no no no no no no Creatinine+blood n6/n3+blood 0.520300752 0 0 serum_choline serum_fattyacid 0.437 0.226 no no no no no no Cystine+blood n6/n3+blood 0 0.490196078 0 yes serum_aminoacids serum_fattyacid 0.00028 0.226 up up no no no no Cytosolic DNA-sensing pathway n6/n3+blood 0 0.576470588 0 kegg serum_fattyacid NA 0.226 no no no no no no d18:1-14:0-SM+blood n6/n3+blood 0 -0.56127451 0 serum_phospholipids serum_fattyacid 0.94 0.226 no no no no no no d18:1-14:1-SM+blood n6/n3+blood 0 -0.526960784 0 serum_phospholipids serum_fattyacid 0.0952 0.226 no dn no no no no d18:1-18:1-SM+blood n6/n3+blood 0.445112782 0 0 serum_phospholipids serum_fattyacid 0.916 0.226 no no no no no no d18:1-20:0-SM+blood n6/n3+blood 0 -0.504901961 0 serum_phospholipids serum_fattyacid 0.933 0.226 no no no no no no d18:1-20:1-SM+blood n6/n3+blood 0.506766917 0 0 serum_phospholipids serum_fattyacid 0.0992 0.226 no no no no no no decanoic acid C10+blood n6/n3+blood 0 0.698529412 0 serum_mcfa serum_fattyacid 6.64E-11 0.226 dn dn no no no no EPA+blood n6/n3+blood -0.47518797 -0.482843137 -0.656068376 serum_ARA serum_fattyacid 0.212 0.226 no no no no no no Ethanolamine+blood n6/n3+blood 0 0.546568627 0 serum_aminoacids serum_fattyacid 0.122 0.226 up no no no no no Ferroptosis n6/n3+blood 0 0.505882353 0 kegg serum_fattyacid NA 0.226 no no no no no no HDCA+blood n6/n3+blood 0 0 -0.46354705 serum_bileacids serum_fattyacid 0.483 0.226 no no no no no no Hepatitis C n6/n3+blood 0 0.591176471 0 kegg serum_fattyacid NA 0.226 no no no no no no heptanoic acid C7+blood n6/n3+blood 0 0.610294118 0 serum_mcfa serum_fattyacid 8.27E-11 0.226 dn dn no no no no Human cytomegalovirus infection n6/n3+blood 0 0.55 0 kegg serum_fattyacid NA 0.226 no no dn no no no Human immunodeficiency virus 1 infection n6/n3+blood 0 0.505882353 0 kegg serum_fattyacid NA 0.226 no no no no no no Hypotaurine+blood n6/n3+blood 0.467669173 0.62745098 0 serum_aminoacids serum_fattyacid 0.933 0.226 no no no no no no iso-DCA+blood n6/n3+blood 0.577443609 0 0 serum_bileacids serum_fattyacid 0.38 0.226 no no no no no no isocapric acid iso-C6+blood n6/n3+blood 0 0 0.460512821 serum_scfa serum_fattyacid 0.0458 0.226 no no dn no no no Kaposi sarcoma-associated herpesvirus infection n6/n3+blood 0 0.797058824 0 kegg serum_fattyacid NA 0.226 no no dn no no no L-Asparagine+blood n6/n3+blood 0 0.654411765 0 serum_aminoacids serum_fattyacid 0.784 0.226 no no no no no no L-Glutamic acid+blood n6/n3+blood 0 0.485294118 0 yes serum_aminoacids serum_fattyacid 6.20E-05 0.226 up up no no no no L-Histidine+blood n6/n3+blood 0.482706767 0.754901961 0 serum_aminoacids serum_fattyacid 0.109 0.226 no no no no no no L-Isoleucine+blood n6/n3+blood 0 0.632352941 0 yes serum_aminoacids serum_fattyacid 5.47E-06 0.226 up up no no no no L-Lysine+blood n6/n3+blood 0 0.507352941 0 yes serum_aminoacids serum_fattyacid 0.0107 0.226 no up no no no no lauric acid C12+blood n6/n3+blood 0.490225564 0.632352941 0 serum_mcfa serum_fattyacid 0.015 0.226 no dn dn no no no Long-term depression n6/n3+blood 0 0.561764706 0 kegg serum_fattyacid NA 0.226 no no no no no no Malaria n6/n3+blood 0 0.576470588 0 kegg serum_fattyacid NA 0.226 no no no no no no MAPK signaling pathway n6/n3+blood 0 -0.505882353 0 kegg serum_fattyacid NA 0.226 no no no no no no MUFA%+blood n6/n3+blood 0.491729323 0 0 serum_fattyacid serum_fattyacid 0.00142 0.226 up no dn no no no n3+blood n6/n3+blood -0.836090226 -0.742647059 -0.717606838 serum_fattyacid serum_fattyacid 0.806 0.226 no no no no no no Necroptosis n6/n3+blood 0 0.55 0 kegg serum_fattyacid NA 0.226 no no no no no no Phenylacetic acid+stool n6/n3+blood 0.587912088 0 0 stool_cometabolism serum_fattyacid 0.785 0.226 no no no no no no Primary immunodeficiency n6/n3+blood 0 -0.505882353 0 kegg serum_fattyacid NA 0.226 no no no no no no Progesterone-mediated oocyte maturation n6/n3+blood 0 -0.544117647 0 kegg serum_fattyacid NA 0.226 no no no no no no Propionic acid+stool n6/n3+blood 0 0 -0.512781955 yes stool_scfa serum_fattyacid 0.0436 0.226 dn no up no no no Ras signaling pathway n6/n3+blood 0 -0.585294118 0 yes kegg serum_fattyacid NA 0.226 no up up no no no Relaxin signaling pathway n6/n3+blood 0 0.535294118 0 kegg serum_fattyacid NA 0.226 no no no no no no Shigellosis n6/n3+blood 0 0.594117647 0 kegg serum_fattyacid NA 0.226 no no no no no no total_stool_scfa+stool n6/n3+blood 0 0 -0.45112782 stool_scfa serum_fattyacid 0.0534 0.226 dn no up no no no 12-ketoDCA+blood n6+blood -0.537758775 0 0 serum_bileacids serum_fattyacid 0.517 0.153 no no no no no no 13-HODE+blood n6+blood 0.457142857 0 0 serum_ARA serum_fattyacid 0.32 0.153 no no no no no no 14:0/16:0-PC+blood n6+blood 0 0 0.402393162 serum_phospholipids serum_fattyacid 0.0358 0.153 no up no no no no 14:0/18:2-PC+blood n6+blood 0 0 0.499487179 serum_phospholipids serum_fattyacid 0.102 0.153 no up no no no no 14:0+blood n6+blood 0.517293233 0 0.549401709 yes serum_fattyacid serum_fattyacid 0.00572 0.153 up no dn no no no 16:0+blood n6+blood 0.815037594 0.884803922 0.688205128 yes serum_fattyacid serum_fattyacid 0.00876 0.153 up no no no no no 16:1/18:2-PG+blood n6+blood 0 0.5 -0.434529915 serum_phospholipids serum_fattyacid 1.40E-08 0.153 no up up no no no 16:1+blood n6+blood 0.559398496 0 0 yes serum_fattyacid serum_fattyacid 0.0186 0.153 no no dn no no no 18:0/18:2-PC+blood n6+blood 0 0.490196078 0 serum_phospholipids serum_fattyacid 1.74E-06 0.153 no up up no no no 18:0+blood n6+blood 0.67518797 0.718137255 0.600683761 serum_fattyacid serum_fattyacid 0.344 0.153 no no no no no no 18:1/18:0-PC+blood n6+blood 0 0.512254902 0 serum_phospholipids serum_fattyacid 1.83E-06 0.153 no up up no no no 18:1/18:0-PS+blood n6+blood 0 0.578431373 0 serum_phospholipids serum_fattyacid 0.193 0.153 no no no no no no 18:1/18:1-PG+blood n6+blood 0 0 -0.483760684 serum_phospholipids serum_fattyacid 0.00352 0.153 no up up no no no 18:1+blood n6+blood 0.720300752 0 0.463247863 yes serum_fattyacid serum_fattyacid 0.00202 0.153 up no dn no no no 18:2/16:0-PC+blood n6+blood 0 0.566176471 0 serum_phospholipids serum_fattyacid 8.67E-05 0.153 no up up no no no 18:2/18:1-PC+blood n6+blood 0 0.492647059 0 serum_phospholipids serum_fattyacid 2.30E-05 0.153 dn up up no no no 18:2n6c+blood n6+blood 0.769924812 0.901960784 0.826324786 serum_fattyacid serum_fattyacid 0.15 0.153 no no no no no no 18:3n3+blood n6+blood 0.494736842 0 0 serum_fattyacid serum_fattyacid 0.291 0.153 no no no no no no 20:0/20:5-PC+blood n6+blood 0 -0.514705882 0 serum_phospholipids serum_fattyacid 0.882 0.153 no no no no no no 20:1-LPA+blood n6+blood 0 0 -0.45025641 serum_phospholipids serum_fattyacid 0.0187 0.153 dn dn no no no no 20:2/18:3-PE+blood n6+blood 0 0.492647059 0 serum_phospholipids serum_fattyacid 0.0391 0.153 up up no no no no 20:2+blood n6+blood 0 0.56127451 0 serum_fattyacid serum_fattyacid 0.478 0.153 no no no no no no 20:3-LPE+blood n6+blood 0.515789474 0 0 serum_phospholipids serum_fattyacid 0.084 0.153 no up no no no no 20:4-LPA+blood n6+blood 0.445112782 0 0 serum_phospholipids serum_fattyacid 0.398 0.153 no no no no no no 20:4/18:0-PE+blood n6+blood 0 0.482843137 0 serum_phospholipids serum_fattyacid 0.000755 0.153 up up no no no no 20:4n6+blood n6+blood 0 0.49754902 0 serum_fattyacid serum_fattyacid 0.133 0.153 no no no no no no 24:0+blood n6+blood 0 0.485294118 0 serum_fattyacid serum_fattyacid 0.034 0.153 dn no up no no no AA+blood n6+blood 0.496240602 0 0 serum_ARA serum_fattyacid 0.212 0.153 no no no no no no Adipocytokine signaling pathway n6+blood 0 0 0.426153846 kegg serum_fattyacid NA 0.153 no no no no no no AGE-RAGE signaling pathway in diabetic complications n6+blood 0.478947368 0 0 kegg serum_fattyacid NA 0.153 no no no no no no AMPK signaling pathway n6+blood 0 0 0.484615385 kegg serum_fattyacid NA 0.153 no no no no no no Bifidobacterium n6+blood 0 -0.606989691 0 acetate-producing Genus serum_fattyacid 0.105 0.153 no dn no no no no Biosynthesis of cofactors n6+blood 0 0 0.622307692 kegg serum_fattyacid NA 0.153 no no no no no no Cardiac muscle contraction n6+blood 0 0 -0.409230769 kegg serum_fattyacid NA 0.153 no no up no no no DCA+blood n6+blood -0.445112782 0 0 serum_bileacids serum_fattyacid 0.122 0.153 no no no no no no Focal adhesion n6+blood 0 0 -0.407692308 kegg serum_fattyacid NA 0.153 no up up no no no GCDCA+blood n6+blood 0 0 -0.411282051 serum_bileacids serum_fattyacid 0.31 0.153 no no no no no no GLCA+blood n6+blood 0 0 -0.447825769 serum_bileacids serum_fattyacid 0.319 0.153 no no no no no no Glutathione metabolism n6+blood 0 0 0.537692308 kegg serum_fattyacid NA 0.153 no no no no no no "Glycine, serine and threonine metabolism" n6+blood 0 -0.647058824 0.596923077 kegg serum_fattyacid NA 0.153 no up no no no no Kaposi sarcoma-associated herpesvirus infection n6+blood -0.470175439 0 0 kegg serum_fattyacid NA 0.153 no no dn no no no L-Proline+blood n6+blood 0 0 -0.440683761 yes serum_aminoacids serum_fattyacid 0.00265 0.153 up up no no no no Lipid and atherosclerosis n6+blood 0.456140351 0 0 kegg serum_fattyacid NA 0.153 no no no no no no Longevity regulating pathway n6+blood 0 0 0.472307692 kegg serum_fattyacid NA 0.153 no no no no no no Malaria n6+blood 0 0 0.409230769 kegg serum_fattyacid NA 0.153 no no no no no no Mitophagy - animal n6+blood -0.459649123 0 0 kegg serum_fattyacid NA 0.153 no no no no no no MUFA+blood n6+blood 0.735338346 0 0.455726496 serum_fattyacid serum_fattyacid 0.00175 0.153 up no dn no no no NOD-like receptor signaling pathway n6+blood 0.459649123 0 0 kegg serum_fattyacid NA 0.153 no no no no no no Pathways of neurodegeneration - multiple diseases n6+blood -0.457894737 0 0 kegg serum_fattyacid NA 0.153 no no no no no no Porphyrin and chlorophyll metabolism n6+blood 0 -0.611764706 0.615384615 kegg serum_fattyacid NA 0.153 no no no no no no Prevotella n6+blood 0 0.563807819 0 acetate-producing Genus serum_fattyacid 0.287 0.153 no no no no no no Ruminococcus n6+blood 0 -0.580882353 0 acetate-producing Genus serum_fattyacid 0.335 0.153 no no no no no no Shigellosis n6+blood -0.596491228 0 0 kegg serum_fattyacid NA 0.153 no no no no no no Sphingolipid signaling pathway n6+blood 0 0 -0.591538462 kegg serum_fattyacid NA 0.153 no no no no no no Thyroid hormone synthesis n6+blood 0 0 0.468461538 kegg serum_fattyacid NA 0.153 no no no no no no Ubiquitin mediated proteolysis n6+blood -0.485964912 0 0.406153846 kegg serum_fattyacid NA 0.153 no no no no no no Adrenergic signaling in cardiomyocytes Natural killer cell mediated cytotoxicity 0 -0.486166008 0 kegg kegg NA NA no no up no no no alpha-Linolenic acid metabolism Natural killer cell mediated cytotoxicity 0.407826087 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Natural killer cell mediated cytotoxicity 0 -0.59486166 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Natural killer cell mediated cytotoxicity 0.684347826 0.509881423 0.615186615 kegg kegg NA NA no no no no no no Apelin signaling pathway Natural killer cell mediated cytotoxicity -0.424347826 -0.416996047 0 kegg kegg NA NA no no no no no no Apoptosis Natural killer cell mediated cytotoxicity 0.537391304 0.752964427 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Natural killer cell mediated cytotoxicity -0.439130435 0 -0.602831403 kegg kegg NA NA no no no no no no Autophagy - other Natural killer cell mediated cytotoxicity -0.465217391 0 0 kegg kegg NA NA no no no no no no Axon guidance Natural killer cell mediated cytotoxicity 0 0.423913043 0 kegg kegg NA NA no up up no no no Basal transcription factors Natural killer cell mediated cytotoxicity -0.679130435 -0.601778656 -0.493951094 kegg kegg NA NA no no no no no no Base excision repair Natural killer cell mediated cytotoxicity -0.426086957 -0.524703557 -0.468468468 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Natural killer cell mediated cytotoxicity 0.720869565 0.677865613 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Natural killer cell mediated cytotoxicity 0 -0.845849802 0 kegg kegg NA NA no no no no no no Butyricicoccus Natural killer cell mediated cytotoxicity 0 0 0.419827251 butyrate-producing Genus kegg 0.852 NA no no no no no no C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity 0 0.62055336 0 kegg kegg NA NA no no no no no no Carbon metabolism Natural killer cell mediated cytotoxicity 0.574782609 0.424901186 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Natural killer cell mediated cytotoxicity -0.417391304 0 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Natural killer cell mediated cytotoxicity 0.893913043 0.951581028 0.865637066 kegg kegg NA NA no no no no no no Cell cycle Natural killer cell mediated cytotoxicity -0.612173913 -0.653162055 0 kegg kegg NA NA no no no no no no Cellular senescence Natural killer cell mediated cytotoxicity 0.917391304 0.975296443 0.918661519 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Natural killer cell mediated cytotoxicity 0 0.605731225 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Natural killer cell mediated cytotoxicity 0 0.540513834 0.537966538 kegg kegg NA NA no no no no no no Complement and coagulation cascades Natural killer cell mediated cytotoxicity 0.725217391 0.627470356 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Natural killer cell mediated cytotoxicity 0 0 0.542084942 kegg kegg NA NA no no no no no no DNA replication Natural killer cell mediated cytotoxicity 0 -0.517786561 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Natural killer cell mediated cytotoxicity 0 -0.429841897 0 kegg kegg NA NA no no no no no no Endocrine resistance Natural killer cell mediated cytotoxicity 0 -0.500988142 0 kegg kegg NA NA no no no no no no Endocytosis Natural killer cell mediated cytotoxicity 0.952173913 0.971343874 0.951608752 kegg kegg NA NA no no no no no no Ether lipid metabolism Natural killer cell mediated cytotoxicity -0.583478261 -0.756916996 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Natural killer cell mediated cytotoxicity -0.470434783 -0.578063241 -0.452767053 kegg kegg NA NA no no no no no no FoxO signaling pathway Natural killer cell mediated cytotoxicity 0 0 -0.493436293 kegg kegg NA NA no no no no no no Galactose metabolism Natural killer cell mediated cytotoxicity 0 0.419960474 0 kegg kegg NA NA no no no no no no Glutathione metabolism Natural killer cell mediated cytotoxicity 0 -0.604743083 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Natural killer cell mediated cytotoxicity -0.666956522 0 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Natural killer cell mediated cytotoxicity 0 -0.735177866 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Natural killer cell mediated cytotoxicity 0.433913043 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Natural killer cell mediated cytotoxicity 0.426086957 0.54743083 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Natural killer cell mediated cytotoxicity 0 -0.731225296 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Natural killer cell mediated cytotoxicity 0 0.423913043 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Natural killer cell mediated cytotoxicity -0.570434783 -0.454545455 0 kegg kegg NA NA no no no no no no Homologous recombination Natural killer cell mediated cytotoxicity 0 -0.489130435 -0.573230373 kegg kegg NA NA no no no no no no Lysosome Natural killer cell mediated cytotoxicity 0.43826087 0.693675889 0 kegg kegg NA NA no no no no no no Mismatch repair Natural killer cell mediated cytotoxicity 0 -0.60770751 0 kegg kegg NA NA no no no no no no Mitophagy - animal Natural killer cell mediated cytotoxicity 0 -0.502964427 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Natural killer cell mediated cytotoxicity -0.682608696 -0.490118577 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Natural killer cell mediated cytotoxicity -0.460869565 -0.47826087 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Natural killer cell mediated cytotoxicity 0 0.660079051 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Natural killer cell mediated cytotoxicity 0.642608696 0.671936759 0.401801802 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Natural killer cell mediated cytotoxicity 0 0.499011858 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Natural killer cell mediated cytotoxicity 0.45826087 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Natural killer cell mediated cytotoxicity 0 0.59486166 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Natural killer cell mediated cytotoxicity -0.428695652 -0.650197628 -0.575289575 kegg kegg NA NA no no no no no no One carbon pool by folate Natural killer cell mediated cytotoxicity -0.479130435 -0.619565217 0 kegg kegg NA NA no no no no no no Oocyte meiosis Natural killer cell mediated cytotoxicity -0.454782609 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Natural killer cell mediated cytotoxicity 0 0.707509881 0.405662806 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Natural killer cell mediated cytotoxicity -0.640869565 -0.513833992 -0.405662806 kegg kegg NA NA no no no no no no Oxidative phosphorylation Natural killer cell mediated cytotoxicity -0.440869565 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Natural killer cell mediated cytotoxicity -0.647826087 -0.416007905 -0.544658945 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Natural killer cell mediated cytotoxicity 0 0.43083004 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Natural killer cell mediated cytotoxicity 0 -0.456521739 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Natural killer cell mediated cytotoxicity 0.669565217 0.718379447 0 kegg kegg NA NA no no no no no no Phagosome Natural killer cell mediated cytotoxicity 0.899130435 0.925889328 0.762676963 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Natural killer cell mediated cytotoxicity -0.574782609 0 0 kegg kegg NA NA no no no no no no Platinum drug resistance Natural killer cell mediated cytotoxicity -0.459130435 0 -0.607464607 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Natural killer cell mediated cytotoxicity 0 -0.730237154 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Natural killer cell mediated cytotoxicity 0.433043478 0.556324111 0.546975547 kegg kegg NA NA no no no no no no Protein export Natural killer cell mediated cytotoxicity -0.610434783 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Natural killer cell mediated cytotoxicity 0 -0.580039526 0 kegg kegg NA NA no no no no no no Purine metabolism Natural killer cell mediated cytotoxicity 0 -0.708498024 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Natural killer cell mediated cytotoxicity 0 -0.516798419 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Natural killer cell mediated cytotoxicity 0 -0.507905138 -0.44041184 kegg kegg NA NA no no no no no no Rap1 signaling pathway Natural killer cell mediated cytotoxicity 0.474782609 0 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Natural killer cell mediated cytotoxicity 0 0.721343874 0 kegg kegg NA NA no no no no no no Retinol metabolism Natural killer cell mediated cytotoxicity 0 -0.438735178 0 kegg kegg NA NA no no no no no no Ribosome Natural killer cell mediated cytotoxicity -0.489565217 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Natural killer cell mediated cytotoxicity -0.59826087 -0.577075099 0 kegg kegg NA NA no no no no no no RNA degradation Natural killer cell mediated cytotoxicity -0.639130435 -0.479249012 0 kegg kegg NA NA no no no no no no RNA polymerase Natural killer cell mediated cytotoxicity -0.568695652 -0.631422925 0 kegg kegg NA NA no no no no no no Ruminococcus Natural killer cell mediated cytotoxicity 0 0 0.434491634 acetate-producing Genus kegg 0.335 NA no no no no no no Selenocompound metabolism Natural killer cell mediated cytotoxicity -0.592173913 -0.490118577 -0.441184041 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Natural killer cell mediated cytotoxicity -0.409565217 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Natural killer cell mediated cytotoxicity 0 0.756916996 0 kegg kegg NA NA no no no no no no Spliceosome Natural killer cell mediated cytotoxicity -0.422608696 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Natural killer cell mediated cytotoxicity -0.648695652 -0.449604743 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Natural killer cell mediated cytotoxicity 0 -0.503952569 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Natural killer cell mediated cytotoxicity 0 -0.621541502 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Natural killer cell mediated cytotoxicity -0.589565217 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Natural killer cell mediated cytotoxicity -0.655652174 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Natural killer cell mediated cytotoxicity -0.522608696 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Natural killer cell mediated cytotoxicity 0 -0.618577075 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Natural killer cell mediated cytotoxicity 0 0.591897233 0.587644788 yes kegg kegg NA NA no no no no no no Tyrosine metabolism Natural killer cell mediated cytotoxicity 0 -0.528656126 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Natural killer cell mediated cytotoxicity 0 -0.518774704 -0.408236808 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Natural killer cell mediated cytotoxicity 0 -0.59486166 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Natural killer cell mediated cytotoxicity 0 -0.480237154 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Natural killer cell mediated cytotoxicity 0 0.442687747 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Natural killer cell mediated cytotoxicity 0.467826087 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Natural killer cell mediated cytotoxicity -0.434782609 -0.459486166 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Necroptosis 0 0 -0.491891892 kegg kegg NA NA no no no no no no ABC transporters Necroptosis -0.46173913 0 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Necroptosis 0 0 -0.403603604 kegg kegg NA NA no no no no no no AMPK signaling pathway Necroptosis 0.447826087 0 0.658429858 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Necroptosis 0 0 0.507335907 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Necroptosis 0 0 -0.449163449 kegg kegg NA NA no no no no no no Autophagy - other Necroptosis 0 0 -0.409009009 kegg kegg NA NA no no no no no no beta-Alanine metabolism Necroptosis -0.429565217 -0.556324111 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Necroptosis 0 0 0.517117117 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Necroptosis -0.493913043 -0.555335968 0 kegg kegg NA NA no no no no no no Butanoate metabolism Necroptosis -0.409565217 -0.425889328 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Necroptosis 0 0.503952569 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Necroptosis -0.430434783 -0.47826087 0 kegg kegg NA NA no no no no no no Cell cycle Necroptosis 0 0 -0.446074646 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Necroptosis -0.442608696 0 -0.4002574 kegg kegg NA NA no no no no no no Endocrine resistance Necroptosis 0.51826087 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Necroptosis 0 0 -0.633719434 kegg kegg NA NA no no no no no no Fanconi anemia pathway Necroptosis 0 0 -0.410553411 kegg kegg NA NA no no no no no no Fatty acid degradation Necroptosis -0.430434783 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Necroptosis -0.512173913 -0.567193676 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Necroptosis -0.466086957 0 0 kegg kegg NA NA no no no no no no Ferroptosis Necroptosis 0.9 0.899209486 0.95984556 kegg kegg NA NA no no no no no no Folate biosynthesis Necroptosis -0.425217391 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Necroptosis -0.489565217 -0.431818182 -0.401029601 kegg kegg NA NA no no no no no no Glutathione metabolism Necroptosis 0.448695652 0 0.606949807 kegg kegg NA NA no no no no no no Glycerolipid metabolism Necroptosis 0 0 -0.6998713 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Necroptosis 0 0 -0.563191763 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Necroptosis 0 0 0.532303732 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Necroptosis 0 0 -0.557271557 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Necroptosis 0 0 -0.545173745 kegg kegg NA NA no no up no no no Inositol phosphate metabolism Necroptosis -0.480869565 0 -0.6002574 kegg kegg NA NA no no no no no no Longevity regulating pathway Necroptosis 0.599130435 0 0.62960103 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Necroptosis 0 -0.556324111 0 kegg kegg NA NA no no no no no no Lysine degradation Necroptosis 0 0 -0.572458172 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Necroptosis 0 0 -0.557014157 kegg kegg NA NA no no no no no no MAPK signaling pathway Necroptosis 0 0 -0.537451737 kegg kegg NA NA no no no no no no Mismatch repair Necroptosis -0.420869565 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Necroptosis 0.762608696 0.609683794 0.784041184 kegg kegg NA NA no no no no no no mRNA surveillance pathway Necroptosis 0 0 -0.404633205 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Necroptosis 0 -0.429841897 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Necroptosis 0 0 -0.518146718 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Necroptosis -0.499130435 -0.442687747 0 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Necroptosis -0.477391304 0 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Necroptosis 0 0 0.400772201 kegg kegg NA NA no no no no no no Non-homologous end-joining Necroptosis -0.494782609 -0.5 0 kegg kegg NA NA no no no no no no Odoribacter Necroptosis 0 -0.456167818 0 butyrate-producing Genus kegg 0.798 NA no no no no no no One carbon pool by folate Necroptosis 0 0 -0.449163449 kegg kegg NA NA no no no no no no Other glycan degradation Necroptosis 0 0 -0.701930502 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Necroptosis 0 0 -0.58970399 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Necroptosis 0 0 -0.458687259 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Necroptosis 0 -0.480237154 -0.572458172 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Necroptosis 0.416521739 0 0.596911197 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Necroptosis -0.503478261 -0.473320158 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Necroptosis 0 0 0.471814672 kegg kegg NA NA no no no no no no Purine metabolism Necroptosis 0.442608696 0 0.749034749 kegg kegg NA NA no no no no no no Ras signaling pathway Necroptosis 0 0 -0.410553411 yes kegg kegg NA NA no up up no no no Retinol metabolism Necroptosis 0 -0.519762846 -0.401287001 kegg kegg NA NA no no no no no no Ribosome Necroptosis 0.500869565 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Necroptosis 0 0 -0.498069498 kegg kegg NA NA no no no no no no RNA degradation Necroptosis 0 0 -0.554697555 kegg kegg NA NA no no no no no no Selenocompound metabolism Necroptosis 0 0 -0.497554698 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Necroptosis 0 0 -0.524324324 kegg kegg NA NA no no no no no no Spliceosome Necroptosis 0 0 -0.467438867 kegg kegg NA NA no no no no no no Sulfur metabolism Necroptosis 0 0 0.487516088 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Necroptosis 0 -0.42687747 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Necroptosis 0 -0.456521739 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Necroptosis -0.43826087 -0.635375494 0 kegg kegg NA NA no up no no no no Ubiquinone and other terpenoid-quinone biosynthesis Necroptosis -0.405217391 -0.490118577 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Necroptosis 0.669565217 0.531620553 0.771943372 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Necroptosis -0.430434783 -0.445652174 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Necroptosis 0 0 -0.635263835 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Neuroactive ligand-receptor interaction 0 0.433794466 0.535907336 kegg kegg NA NA no no no up up up Amino sugar and nucleotide sugar metabolism Neuroactive ligand-receptor interaction 0.424347826 0 0 kegg kegg NA NA no no no up up up Aminoacyl-tRNA biosynthesis Neuroactive ligand-receptor interaction 0 -0.463438735 0 kegg kegg NA NA no no no up up up Antifolate resistance Neuroactive ligand-receptor interaction 0 -0.470355731 0 kegg kegg NA NA no no no up up up Arginine and proline metabolism Neuroactive ligand-receptor interaction 0 0.535573123 0.524066924 kegg kegg NA NA no up no up up up Arginine biosynthesis Neuroactive ligand-receptor interaction 0 0.493083004 0.608236808 kegg kegg NA NA no no no up up up Basal transcription factors Neuroactive ligand-receptor interaction 0 -0.536561265 -0.473101673 kegg kegg NA NA no no no up up up Base excision repair Neuroactive ligand-receptor interaction 0 -0.517786561 -0.442728443 kegg kegg NA NA no no no up up up Biosynthesis of amino acids Neuroactive ligand-receptor interaction 0.500869565 0.785573123 0.74002574 kegg kegg NA NA no no no up up up Biosynthesis of cofactors Neuroactive ligand-receptor interaction 0 -0.536561265 0 kegg kegg NA NA no no no up up up Calcium signaling pathway Neuroactive ligand-receptor interaction 0 -0.530632411 -0.497554698 kegg kegg NA NA no up up up up up Carbon metabolism Neuroactive ligand-receptor interaction 0.468695652 0.636363636 0.723037323 kegg kegg NA NA no no no up up up cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction 0 0.783596838 0.59047619 kegg kegg NA NA no no no up up up Chemokine signaling pathway Neuroactive ligand-receptor interaction 0 0.549407115 0.421879022 kegg kegg NA NA no no no up up up Cysteine and methionine metabolism Neuroactive ligand-receptor interaction 0 0 -0.418532819 kegg kegg NA NA no no no up up up Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction 0 0.540513834 0 kegg kegg NA NA no no no up up up DNA replication Neuroactive ligand-receptor interaction 0 -0.496047431 -0.414414414 kegg kegg NA NA no no no up up up Drug metabolism - other enzymes Neuroactive ligand-receptor interaction 0.422608696 0 0 kegg kegg NA NA no no no up up up EGFR tyrosine kinase inhibitor resistance Neuroactive ligand-receptor interaction 0 -0.494071146 0 kegg kegg NA NA no no no up up up Endocrine resistance Neuroactive ligand-receptor interaction -0.517391304 -0.640316206 0 kegg kegg NA NA no no no up up up ErbB signaling pathway Neuroactive ligand-receptor interaction -0.417391304 0 0 kegg kegg NA NA no no no up up up Ether lipid metabolism Neuroactive ligand-receptor interaction 0 -0.466403162 0 kegg kegg NA NA no no no up up up Fanconi anemia pathway Neuroactive ligand-receptor interaction 0 -0.591897233 -0.454311454 kegg kegg NA NA no no no up up up Fatty acid biosynthesis Neuroactive ligand-receptor interaction 0 0.504940711 0.548005148 kegg kegg NA NA no no no up up up Fatty acid degradation Neuroactive ligand-receptor interaction 0 0.428853755 0.418790219 kegg kegg NA NA no no no up up up Fatty acid elongation Neuroactive ligand-receptor interaction 0.457391304 0 0 kegg kegg NA NA no no no up up up Fatty acid metabolism Neuroactive ligand-receptor interaction 0 0.57312253 0.445817246 kegg kegg NA NA no no no up up up Glutathione metabolism Neuroactive ligand-receptor interaction 0 -0.509881423 0 kegg kegg NA NA no no no up up up Glycerophospholipid metabolism Neuroactive ligand-receptor interaction 0 0 -0.402574003 kegg kegg NA NA no no up up up up "Glycine, serine and threonine metabolism" Neuroactive ligand-receptor interaction 0 -0.520750988 0 kegg kegg NA NA no up no up up up Glycosaminoglycan degradation Neuroactive ligand-receptor interaction 0.506086957 0.662055336 0 kegg kegg NA NA no no up up up up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Neuroactive ligand-receptor interaction 0 -0.546442688 0 kegg kegg NA NA no no no up up up Glyoxylate and dicarboxylate metabolism Neuroactive ligand-receptor interaction 0 0.519762846 0.643243243 kegg kegg NA NA no no no up up up Homologous recombination Neuroactive ligand-receptor interaction 0 -0.501976285 -0.516087516 kegg kegg NA NA no no no up up up Lysine degradation Neuroactive ligand-receptor interaction -0.426956522 -0.666996047 -0.573230373 kegg kegg NA NA no no no up up up Mannose type O-glycan biosynthesis Neuroactive ligand-receptor interaction -0.453043478 -0.545454545 -0.528442728 kegg kegg NA NA no no no up up up mRNA surveillance pathway Neuroactive ligand-receptor interaction -0.432173913 -0.747035573 -0.711196911 kegg kegg NA NA no no no up up up Mucin type O-glycan biosynthesis Neuroactive ligand-receptor interaction 0.492173913 0 0 kegg kegg NA NA no no no up up up N-Glycan biosynthesis Neuroactive ligand-receptor interaction 0 -0.544466403 -0.533075933 kegg kegg NA NA no no no up up up Nicotinate and nicotinamide metabolism Neuroactive ligand-receptor interaction 0 0.570158103 0.75984556 kegg kegg NA NA no no no up up up Nitrogen metabolism Neuroactive ligand-receptor interaction 0 0.441699605 0.436550837 kegg kegg NA NA no no no up up up Nucleotide excision repair Neuroactive ligand-receptor interaction 0 -0.468379447 -0.43037323 kegg kegg NA NA no no no up up up Odoribacter Neuroactive ligand-receptor interaction 0 0.448738375 0 butyrate-producing Genus kegg 0.798 NA no no no up up up One carbon pool by folate Neuroactive ligand-receptor interaction 0 -0.490118577 -0.532046332 kegg kegg NA NA no no no up up up Other types of O-glycan biosynthesis Neuroactive ligand-receptor interaction 0 -0.657114625 -0.558301158 kegg kegg NA NA no no no up up up Oxidative phosphorylation Neuroactive ligand-receptor interaction 0 -0.475296443 0 kegg kegg NA NA no no no up up up Pantothenate and CoA biosynthesis Neuroactive ligand-receptor interaction 0.586086957 0.669960474 0.748005148 kegg kegg NA NA no no dn up up up Pentose phosphate pathway Neuroactive ligand-receptor interaction 0.505217391 0.890316206 0.805148005 kegg kegg NA NA no no no up up up Phosphatidylinositol signaling system Neuroactive ligand-receptor interaction 0 0 -0.516602317 kegg kegg NA NA no no no up up up Porphyrin and chlorophyll metabolism Neuroactive ligand-receptor interaction 0 -0.486166008 0 kegg kegg NA NA no no no up up up PPAR signaling pathway Neuroactive ligand-receptor interaction 0 0.564229249 0.654311454 kegg kegg NA NA no no no up up up Protein export Neuroactive ligand-receptor interaction 0 0 -0.448391248 kegg kegg NA NA no no no up up up Purine metabolism Neuroactive ligand-receptor interaction -0.451304348 -0.610671937 0 kegg kegg NA NA no no no up up up Retinol metabolism Neuroactive ligand-receptor interaction 0.473043478 0 0 kegg kegg NA NA no no no up up up Ribosome Neuroactive ligand-receptor interaction -0.516521739 -0.485177866 0 kegg kegg NA NA no no no up up up Ribosome biogenesis in eukaryotes Neuroactive ligand-receptor interaction -0.408695652 -0.674901186 -0.616216216 kegg kegg NA NA no no no up up up RNA degradation Neuroactive ligand-receptor interaction -0.409565217 -0.681818182 -0.629086229 kegg kegg NA NA no no no up up up RNA polymerase Neuroactive ligand-receptor interaction 0 -0.756916996 -0.473359073 kegg kegg NA NA no no no up up up Selenocompound metabolism Neuroactive ligand-receptor interaction 0 -0.431818182 0 kegg kegg NA NA no no no up up up Sphingolipid signaling pathway Neuroactive ligand-receptor interaction 0 0.586956522 0 kegg kegg NA NA no no no up up up Spliceosome Neuroactive ligand-receptor interaction 0 -0.516798419 -0.586872587 kegg kegg NA NA no no no up up up Starch and sucrose metabolism Neuroactive ligand-receptor interaction 0.566956522 0.529644269 0.489060489 kegg kegg NA NA no no no up up up Steroid hormone biosynthesis Neuroactive ligand-receptor interaction 0.491304348 0 0 kegg kegg NA NA no no no up up up Taurine and hypotaurine metabolism Neuroactive ligand-receptor interaction -0.413043478 0 -0.448648649 kegg kegg NA NA no no no up up up Viral protein interaction with cytokine and cytokine receptor Neuroactive ligand-receptor interaction 0 0.553359684 0 kegg kegg NA NA no no no up up up 2-Oxocarboxylic acid metabolism Neurotrophin signaling pathway -0.645217391 -0.470355731 0 kegg kegg NA NA no no no no no no Adherens junction Neurotrophin signaling pathway 0 -0.425889328 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Neurotrophin signaling pathway 0.503478261 0 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Neurotrophin signaling pathway 0 0.4743083 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Neurotrophin signaling pathway -0.425217391 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Neurotrophin signaling pathway -0.644347826 -0.434782609 -0.504761905 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Neurotrophin signaling pathway -0.544347826 -0.530632411 0 kegg kegg NA NA no no no no no no Anaerostipes Neurotrophin signaling pathway 0 0 -0.445015205 butyrate-producing Genus kegg 0.568 NA no no no no no no Antifolate resistance Neurotrophin signaling pathway -0.464347826 -0.540513834 0 kegg kegg NA NA no no no no no no Apoptosis Neurotrophin signaling pathway 0 0.744071146 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Neurotrophin signaling pathway -0.560869565 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Neurotrophin signaling pathway 0 0.565217391 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Neurotrophin signaling pathway 0 0.470355731 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Neurotrophin signaling pathway 0 -0.419960474 0 kegg kegg NA NA no no no no no no Autophagy - animal Neurotrophin signaling pathway 0.493913043 0.704545455 0 kegg kegg NA NA no no no no no no Autophagy - other Neurotrophin signaling pathway 0.589565217 0.416996047 0.432175032 kegg kegg NA NA no no no no no no Axon guidance Neurotrophin signaling pathway 0.833043478 0.4743083 0.528185328 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Neurotrophin signaling pathway 0.535652174 0.858695652 0.762419562 kegg kegg NA NA no no no no no no Basal transcription factors Neurotrophin signaling pathway 0 -0.514822134 0 kegg kegg NA NA no no no no no no Base excision repair Neurotrophin signaling pathway 0 -0.479249012 -0.424195624 kegg kegg NA NA no no no no no no beta-Alanine metabolism Neurotrophin signaling pathway -0.776521739 -0.557312253 -0.688030888 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Neurotrophin signaling pathway -0.473043478 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Neurotrophin signaling pathway -0.624347826 -0.641304348 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Neurotrophin signaling pathway -0.651304348 -0.635375494 -0.629086229 kegg kegg NA NA no no no no no no Butanoate metabolism Neurotrophin signaling pathway -0.703478261 -0.703557312 -0.641441441 kegg kegg NA NA no no no no no no Butyricimonas Neurotrophin signaling pathway 0.406906307 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no C-type lectin receptor signaling pathway Neurotrophin signaling pathway 0.790434783 0.895256917 0.816473616 kegg kegg NA NA no no no no no no Calcium signaling pathway Neurotrophin signaling pathway 0.52173913 0 0.483397683 kegg kegg NA NA no up up no no no cAMP signaling pathway Neurotrophin signaling pathway 0.770434783 0.694664032 0.648133848 yes kegg kegg NA NA no up up no no no Carbon metabolism Neurotrophin signaling pathway -0.608695652 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Neurotrophin signaling pathway 0.560869565 0 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Neurotrophin signaling pathway 0 0.482213439 0 kegg kegg NA NA no no no no no no Cell cycle Neurotrophin signaling pathway 0 -0.565217391 0 kegg kegg NA NA no no no no no no Cellular senescence Neurotrophin signaling pathway 0 0.634387352 0.482110682 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Neurotrophin signaling pathway 0 0.492094862 0.544658945 kegg kegg NA NA no no no no no no Chemokine signaling pathway Neurotrophin signaling pathway 0.626086957 0.601778656 0 kegg kegg NA NA no no no no no no Circadian entrainment Neurotrophin signaling pathway 0 -0.746047431 0 kegg kegg NA NA no up up no no no Circadian rhythm Neurotrophin signaling pathway 0.682608696 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Neurotrophin signaling pathway -0.64 -0.687747036 0 kegg kegg NA NA no no no no no no Collinsella Neurotrophin signaling pathway 0 0 -0.413097427 Genus kegg 0.128 NA no no no no no no Cysteine and methionine metabolism Neurotrophin signaling pathway 0 -0.626482213 -0.459459459 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Neurotrophin signaling pathway 0 0 -0.422651223 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Neurotrophin signaling pathway 0.474782609 0.839920949 0.612870013 kegg kegg NA NA no no no no no no DNA replication Neurotrophin signaling pathway 0 -0.741106719 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Neurotrophin signaling pathway 0 -0.709486166 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Neurotrophin signaling pathway -0.64 -0.572134387 0 kegg kegg NA NA no no no no no no Endocytosis Neurotrophin signaling pathway 0 0.489130435 0.410553411 kegg kegg NA NA no no no no no no ErbB signaling pathway Neurotrophin signaling pathway 0.607826087 0.54743083 0.495238095 kegg kegg NA NA no no no no no no Ether lipid metabolism Neurotrophin signaling pathway 0 -0.504940711 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Neurotrophin signaling pathway 0 -0.523715415 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Neurotrophin signaling pathway 0 0.441699605 0 kegg kegg NA NA no no no no no no Fatty acid degradation Neurotrophin signaling pathway -0.471304348 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Neurotrophin signaling pathway -0.644347826 -0.470355731 -0.602316602 kegg kegg NA NA no no no no no no Fatty acid metabolism Neurotrophin signaling pathway -0.546956522 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Neurotrophin signaling pathway 0.486086957 0.695652174 0.457142857 kegg kegg NA NA no no no no no no Focal adhesion Neurotrophin signaling pathway 0 -0.504940711 0 kegg kegg NA NA no up up no no no Fructose and mannose metabolism Neurotrophin signaling pathway -0.571304348 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Neurotrophin signaling pathway -0.597391304 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Neurotrophin signaling pathway 0 -0.505928854 -0.483912484 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Neurotrophin signaling pathway -0.468695652 -0.48715415 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Neurotrophin signaling pathway -0.664347826 -0.42687747 -0.496010296 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Neurotrophin signaling pathway 0 0.583992095 0.52020592 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Neurotrophin signaling pathway -0.439130435 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Neurotrophin signaling pathway 0 -0.542490119 -0.404633205 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Neurotrophin signaling pathway 0.471304348 0 0.527155727 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Neurotrophin signaling pathway 0 0.514822134 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Neurotrophin signaling pathway 0 -0.421936759 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Neurotrophin signaling pathway -0.548695652 0 -0.529214929 kegg kegg NA NA no no no no no no Hippo signaling pathway Neurotrophin signaling pathway 0 -0.476284585 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Neurotrophin signaling pathway 0 0.422924901 0.402059202 kegg kegg NA NA no no no no no no Histidine metabolism Neurotrophin signaling pathway -0.603478261 0 -0.474646075 kegg kegg NA NA no no no no no no IL-17 signaling pathway Neurotrophin signaling pathway 0 0.511857708 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Neurotrophin signaling pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Long-term potentiation Neurotrophin signaling pathway 0.406956522 -0.431818182 0.434234234 kegg kegg NA NA no no up no no no Longevity regulating pathway - multiple species Neurotrophin signaling pathway 0 0 -0.663835264 kegg kegg NA NA no no no no no no Lysosome Neurotrophin signaling pathway 0 0.416007905 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Neurotrophin signaling pathway 0.55826087 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Neurotrophin signaling pathway 0 -0.70256917 0 kegg kegg NA NA no no no no no no Mismatch repair Neurotrophin signaling pathway -0.568695652 -0.774703557 -0.538223938 kegg kegg NA NA no no no no no no mRNA surveillance pathway Neurotrophin signaling pathway 0.566956522 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Neurotrophin signaling pathway 0 -0.550395257 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Neurotrophin signaling pathway 0 0.538537549 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Neurotrophin signaling pathway 0 0.742094862 0.619305019 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Neurotrophin signaling pathway 0 0.473320158 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Neurotrophin signaling pathway 0 0.499011858 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Neurotrophin signaling pathway 0 0.744071146 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Neurotrophin signaling pathway -0.697391304 -0.581027668 -0.639382239 kegg kegg NA NA no no no no no no Nucleotide excision repair Neurotrophin signaling pathway -0.42 -0.801383399 -0.553667954 kegg kegg NA NA no no no no no no One carbon pool by folate Neurotrophin signaling pathway -0.506086957 -0.827075099 0 kegg kegg NA NA no no no no no no Oocyte meiosis Neurotrophin signaling pathway 0 -0.538537549 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Neurotrophin signaling pathway 0 0.649209486 0.464092664 kegg kegg NA NA no no no no no no Oxidative phosphorylation Neurotrophin signaling pathway 0.507826087 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Neurotrophin signaling pathway -0.482608696 -0.62055336 0 kegg kegg NA NA no no no no no no Phagosome Neurotrophin signaling pathway 0 0.429841897 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Neurotrophin signaling pathway -0.689565217 -0.716403162 -0.487516088 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Neurotrophin signaling pathway 0.433043478 -0.416996047 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Neurotrophin signaling pathway 0 0.490118577 0.47979408 kegg kegg NA NA no up up no no no Platelet activation Neurotrophin signaling pathway 0 -0.473320158 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Neurotrophin signaling pathway -0.485217391 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Neurotrophin signaling pathway 0 0.733201581 0.506306306 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Neurotrophin signaling pathway -0.686956522 -0.578063241 -0.520978121 kegg kegg NA NA no no no no no no Propanoate metabolism Neurotrophin signaling pathway -0.485217391 -0.595849802 -0.48005148 kegg kegg NA NA no no no no no no Proteasome Neurotrophin signaling pathway 0 -0.45256917 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Neurotrophin signaling pathway 0 -0.499011858 0 kegg kegg NA NA no no no no no no Purine metabolism Neurotrophin signaling pathway 0 -0.416996047 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Neurotrophin signaling pathway -0.704347826 -0.772727273 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Neurotrophin signaling pathway -0.607826087 -0.643280632 -0.708108108 kegg kegg NA NA no no no no no no Ras signaling pathway Neurotrophin signaling pathway 0.486956522 -0.500988142 0 yes kegg kegg NA NA no up up no no no Renin-angiotensin system Neurotrophin signaling pathway 0 0.462450593 0 kegg kegg NA NA no no no no no no Retinol metabolism Neurotrophin signaling pathway -0.624347826 -0.82312253 0 kegg kegg NA NA no no no no no no Ribosome Neurotrophin signaling pathway 0.408695652 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Neurotrophin signaling pathway 0 -0.576086957 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Neurotrophin signaling pathway 0.652173913 0.796442688 0.714028314 kegg kegg NA NA no no no no no no RNA degradation Neurotrophin signaling pathway 0.526956522 0 0 kegg kegg NA NA no no no no no no RNA polymerase Neurotrophin signaling pathway 0 -0.567193676 0 kegg kegg NA NA no no no no no no Roseburia Neurotrophin signaling pathway -0.408695652 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Sarcina Neurotrophin signaling pathway 0 0.466781936 0 Genus kegg 0.0703 NA no no no no no no Signaling pathways regulating pluripotency of stem cells Neurotrophin signaling pathway 0.72 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Neurotrophin signaling pathway 0 0.416996047 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Neurotrophin signaling pathway 0.722608696 0.747035573 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Neurotrophin signaling pathway 0 -0.813241107 -0.501930502 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Neurotrophin signaling pathway -0.619130435 -0.794466403 0 kegg kegg NA NA no no no no no no Sulfur metabolism Neurotrophin signaling pathway -0.531304348 -0.476284585 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Neurotrophin signaling pathway -0.549565217 -0.788537549 -0.4996139 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Neurotrophin signaling pathway 0.593913043 0.622529644 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Neurotrophin signaling pathway 0 -0.524703557 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Neurotrophin signaling pathway 0.439130435 0 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Neurotrophin signaling pathway 0 0.559288538 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Neurotrophin signaling pathway 0 0.644268775 0 kegg kegg NA NA no no no no no no Thermogenesis Neurotrophin signaling pathway 0.434782609 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Neurotrophin signaling pathway 0 -0.466403162 0 kegg kegg NA NA no no no no no no Tight junction Neurotrophin signaling pathway 0 -0.418972332 -0.436808237 kegg kegg NA NA no no no no no no TNF signaling pathway Neurotrophin signaling pathway 0.823478261 0.896245059 0.853796654 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Neurotrophin signaling pathway 0.613913043 0.835968379 0.74954955 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Neurotrophin signaling pathway -0.783478261 -0.685770751 -0.44041184 kegg kegg NA NA no up no no no no Tyrosine metabolism Neurotrophin signaling pathway -0.827826087 -0.871541502 -0.796138996 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Neurotrophin signaling pathway -0.715652174 -0.805335968 -0.505534106 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Neurotrophin signaling pathway -0.707826087 -0.779644269 -0.631660232 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Neurotrophin signaling pathway 0 -0.516798419 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Neurotrophin signaling pathway 0.713913043 0.646245059 0.586100386 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Neurotrophin signaling pathway 0.420869565 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Neurotrophin signaling pathway 0.46173913 -0.43972332 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Neutrophil extracellular trap formation 0 -0.539525692 0 kegg kegg NA NA no no no no no no Adherens junction Neutrophil extracellular trap formation 0.424347826 0 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Neutrophil extracellular trap formation -0.47826087 -0.643280632 -0.544401544 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Neutrophil extracellular trap formation 0.486956522 0.566205534 0.516602317 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Neutrophil extracellular trap formation 0.48 0.509881423 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Neutrophil extracellular trap formation 0 -0.565217391 -0.436293436 kegg kegg NA NA no no no no no no AMPK signaling pathway Neutrophil extracellular trap formation 0 -0.654150198 0 kegg kegg NA NA no no no no no no Anaerostipes Neutrophil extracellular trap formation 0 -0.436139493 0 butyrate-producing Genus kegg 0.568 NA no no no no no no Antifolate resistance Neutrophil extracellular trap formation 0 -0.47826087 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Neutrophil extracellular trap formation 0.444347826 0 0.543886744 kegg kegg NA NA no no no no no no Apelin signaling pathway Neutrophil extracellular trap formation -0.616521739 -0.561264822 0 kegg kegg NA NA no no no no no no Apoptosis Neutrophil extracellular trap formation 0.766956522 0.666007905 0.769369369 kegg kegg NA NA no no no no no no Apoptosis - multiple species Neutrophil extracellular trap formation -0.467826087 0 -0.476705277 kegg kegg NA NA no no no no no no Arginine and proline metabolism Neutrophil extracellular trap formation 0.595652174 0.630434783 0.484942085 kegg kegg NA NA no up no no no no Arginine biosynthesis Neutrophil extracellular trap formation 0.622608696 0.626482213 0.616731017 kegg kegg NA NA no no no no no no Autophagy - other Neutrophil extracellular trap formation -0.505217391 0 -0.662290862 kegg kegg NA NA no no no no no no Basal transcription factors Neutrophil extracellular trap formation -0.666086957 -0.706521739 -0.763963964 kegg kegg NA NA no no no no no no Base excision repair Neutrophil extracellular trap formation -0.55826087 -0.638339921 -0.583011583 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Neutrophil extracellular trap formation 0.689565217 0.847826087 0.847104247 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Neutrophil extracellular trap formation 0 -0.602766798 0 kegg kegg NA NA no no no no no no Butanoate metabolism Neutrophil extracellular trap formation 0 -0.460474308 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Neutrophil extracellular trap formation -0.496521739 -0.462450593 -0.52972973 kegg kegg NA NA no up up no no no Carbon metabolism Neutrophil extracellular trap formation 0.47826087 0.503952569 0.736164736 kegg kegg NA NA no no no no no no Cardiac muscle contraction Neutrophil extracellular trap formation -0.414782609 -0.507905138 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Neutrophil extracellular trap formation 0.515652174 0.654150198 0.497554698 kegg kegg NA NA no no no no no no Cell cycle Neutrophil extracellular trap formation -0.592173913 -0.803359684 -0.796911197 kegg kegg NA NA no no no no no no Cellular senescence Neutrophil extracellular trap formation 0.484347826 0.621541502 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Neutrophil extracellular trap formation 0 0.878458498 0.447361647 kegg kegg NA NA no no no no no no Chemokine signaling pathway Neutrophil extracellular trap formation 0 0.701581028 0.564736165 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Neutrophil extracellular trap formation 0 -0.445652174 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Neutrophil extracellular trap formation 0.706086957 0.896245059 0.793050193 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Neutrophil extracellular trap formation 0 -0.451581028 -0.425740026 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Neutrophil extracellular trap formation 0 0.572134387 0 kegg kegg NA NA no no no no no no DNA replication Neutrophil extracellular trap formation -0.486086957 -0.635375494 -0.585070785 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Neutrophil extracellular trap formation 0 -0.5 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Neutrophil extracellular trap formation -0.462608696 0 -0.481338481 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Neutrophil extracellular trap formation -0.616521739 -0.564229249 0 kegg kegg NA NA no no no no no no Endocrine resistance Neutrophil extracellular trap formation -0.560869565 -0.463438735 0 kegg kegg NA NA no no no no no no Endocytosis Neutrophil extracellular trap formation 0.656521739 0.706521739 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Neutrophil extracellular trap formation -0.489565217 -0.605731225 -0.521235521 kegg kegg NA NA no no no no no no Fanconi anemia pathway Neutrophil extracellular trap formation -0.465217391 -0.625494071 -0.663320463 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Neutrophil extracellular trap formation 0.546956522 0.658102767 0.408751609 kegg kegg NA NA no no no no no no Fatty acid degradation Neutrophil extracellular trap formation 0.483478261 0.455533597 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Neutrophil extracellular trap formation 0.575652174 0.584980237 0 kegg kegg NA NA no no no no no no Folate biosynthesis Neutrophil extracellular trap formation 0 -0.543478261 0 kegg kegg NA NA no no no no no no Galactose metabolism Neutrophil extracellular trap formation 0.525217391 0.468379447 0 kegg kegg NA NA no no no no no no Glutathione metabolism Neutrophil extracellular trap formation 0 -0.542490119 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Neutrophil extracellular trap formation 0 0 -0.447619048 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Neutrophil extracellular trap formation 0 0 -0.595366795 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Neutrophil extracellular trap formation 0 -0.5 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Neutrophil extracellular trap formation 0.611304348 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Neutrophil extracellular trap formation 0 -0.424901186 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Neutrophil extracellular trap formation -0.430434783 -0.451581028 -0.557528958 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Neutrophil extracellular trap formation 0.610434783 0.603754941 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Neutrophil extracellular trap formation 0 -0.509881423 -0.401287001 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Neutrophil extracellular trap formation 0 0 -0.422651223 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Neutrophil extracellular trap formation 0 -0.531620553 -0.501673102 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Neutrophil extracellular trap formation 0.56173913 0.648221344 0.633976834 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Neutrophil extracellular trap formation -0.440869565 -0.665019763 -0.732046332 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Neutrophil extracellular trap formation -0.516521739 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Neutrophil extracellular trap formation 0 0.446640316 0 kegg kegg NA NA no no no no no no Homologous recombination Neutrophil extracellular trap formation 0 -0.484189723 -0.656628057 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Neutrophil extracellular trap formation 0 0 -0.527413127 kegg kegg NA NA no no no no no no Lysine degradation Neutrophil extracellular trap formation -0.566086957 -0.717391304 -0.763449163 kegg kegg NA NA no no no no no no Lysosome Neutrophil extracellular trap formation 0.759130435 0.860671937 0.741827542 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Neutrophil extracellular trap formation -0.44 -0.638339921 -0.728185328 kegg kegg NA NA no no no no no no Mismatch repair Neutrophil extracellular trap formation 0 -0.448616601 0 kegg kegg NA NA no no no no no no Mitophagy - animal Neutrophil extracellular trap formation -0.54173913 -0.54743083 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Neutrophil extracellular trap formation -0.668695652 -0.865612648 -0.848648649 kegg kegg NA NA no no no no no no mTOR signaling pathway Neutrophil extracellular trap formation -0.62173913 -0.56916996 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Neutrophil extracellular trap formation -0.669565217 -0.749011858 -0.665894466 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Neutrophil extracellular trap formation 0.664347826 0.897233202 0.818532819 kegg kegg NA NA up up up no no no Nicotinate and nicotinamide metabolism Neutrophil extracellular trap formation 0.705217391 0.764822134 0.667438867 kegg kegg NA NA no no no no no no Nitrogen metabolism Neutrophil extracellular trap formation 0.64 0.595849802 0.488288288 kegg kegg NA NA no no no no no no Notch signaling pathway Neutrophil extracellular trap formation 0 0 -0.422908623 kegg kegg NA NA no no no no no no Nucleotide excision repair Neutrophil extracellular trap formation -0.453043478 -0.604743083 -0.54028314 kegg kegg NA NA no no no no no no One carbon pool by folate Neutrophil extracellular trap formation -0.427826087 -0.588932806 -0.622393822 kegg kegg NA NA no no no no no no Oocyte meiosis Neutrophil extracellular trap formation -0.553913043 0 -0.516087516 kegg kegg NA NA no no no no no no Osteoclast differentiation Neutrophil extracellular trap formation 0.816521739 0.793478261 0.718404118 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Neutrophil extracellular trap formation -0.607826087 -0.661067194 -0.763963964 kegg kegg NA NA no no no no no no Oxidative phosphorylation Neutrophil extracellular trap formation -0.433043478 -0.48715415 0 kegg kegg NA NA no no no no no no p53 signaling pathway Neutrophil extracellular trap formation -0.569565217 -0.420948617 -0.675160875 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Neutrophil extracellular trap formation 0.677391304 0.753952569 0.557528958 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Neutrophil extracellular trap formation 0 -0.625494071 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Neutrophil extracellular trap formation 0.831304348 0.955533597 0.796396396 kegg kegg NA NA no no no no no no Peroxisome Neutrophil extracellular trap formation 0.586956522 0.66798419 0.585585586 kegg kegg NA NA no no no no no no Phagosome Neutrophil extracellular trap formation 0.725217391 0.81916996 0.758815959 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Neutrophil extracellular trap formation -0.584347826 -0.427865613 -0.731531532 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Neutrophil extracellular trap formation 0 0.414031621 0 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Neutrophil extracellular trap formation 0 0 -0.417760618 yes kegg kegg NA NA no up up no no no Platelet activation Neutrophil extracellular trap formation 0 0 0.482368082 kegg kegg NA NA no no no no no no Platinum drug resistance Neutrophil extracellular trap formation -0.465217391 0 -0.57039897 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Neutrophil extracellular trap formation 0 -0.498023715 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Neutrophil extracellular trap formation 0 0.605731225 0.59047619 kegg kegg NA NA no no no no no no Protein export Neutrophil extracellular trap formation -0.810434783 -0.559288538 -0.564993565 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Neutrophil extracellular trap formation -0.659130435 -0.847826087 0 kegg kegg NA NA no no no no no no Purine metabolism Neutrophil extracellular trap formation 0 -0.601778656 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Neutrophil extracellular trap formation 0 -0.427865613 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Neutrophil extracellular trap formation 0 -0.546442688 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Neutrophil extracellular trap formation 0.492173913 0 0.554182754 kegg kegg NA NA no no no no no no Ras signaling pathway Neutrophil extracellular trap formation 0 0 -0.557528958 yes kegg kegg NA NA no up up no no no Ribosome Neutrophil extracellular trap formation -0.76 -0.516798419 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Neutrophil extracellular trap formation -0.737391304 -0.756916996 -0.788416988 kegg kegg NA NA no no no no no no RNA degradation Neutrophil extracellular trap formation -0.673043478 -0.828063241 -0.782496782 kegg kegg NA NA no no no no no no RNA polymerase Neutrophil extracellular trap formation -0.79826087 -0.85770751 -0.66048906 kegg kegg NA NA no no no no no no RNA transport Neutrophil extracellular trap formation 0 -0.526679842 0 kegg kegg NA NA no no no no no no Ruminococcus Neutrophil extracellular trap formation -0.615652174 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Selenocompound metabolism Neutrophil extracellular trap formation -0.492173913 -0.479249012 -0.579150579 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Neutrophil extracellular trap formation -0.468695652 -0.501976285 -0.675160875 kegg kegg NA NA no no no no no no Slackia Neutrophil extracellular trap formation 0 0 -0.413897497 Genus kegg 0.94 NA no no no no no no Sphingolipid metabolism Neutrophil extracellular trap formation 0.586956522 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Neutrophil extracellular trap formation 0 0.538537549 0 kegg kegg NA NA no no no no no no Spliceosome Neutrophil extracellular trap formation -0.615652174 -0.565217391 -0.752638353 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Neutrophil extracellular trap formation 0.751304348 0.66798419 0.404375804 kegg kegg NA NA no no no no no no Steroid biosynthesis Neutrophil extracellular trap formation -0.608695652 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Neutrophil extracellular trap formation 0 -0.48715415 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Neutrophil extracellular trap formation 0 0 -0.507593308 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Neutrophil extracellular trap formation -0.494782609 0 -0.546975547 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Neutrophil extracellular trap formation -0.472173913 -0.432806324 -0.475418275 kegg kegg NA NA no no no no no no Thiamine metabolism Neutrophil extracellular trap formation 0 -0.484189723 0 kegg kegg NA NA no no no no no no Tight junction Neutrophil extracellular trap formation 0.411304348 0 0.605662806 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Neutrophil extracellular trap formation 0 -0.420948617 -0.478249678 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Neutrophil extracellular trap formation -0.655652174 -0.670948617 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Neutrophil extracellular trap formation 0 -0.4743083 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Neutrophil extracellular trap formation -0.580869565 -0.656126482 -0.525868726 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Neutrophil extracellular trap formation -0.451304348 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Neutrophil extracellular trap formation 0 0.632411067 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Neutrophil extracellular trap formation 0 -0.756916996 -0.670527671 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism NF-kappa B signaling pathway 0 -0.542490119 0 kegg kegg NA NA no no no no no no ABC transporters NF-kappa B signaling pathway 0.623478261 0.482213439 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" NF-kappa B signaling pathway 0.551304348 0.791501976 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism NF-kappa B signaling pathway 0 0.531620553 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism NF-kappa B signaling pathway -0.522608696 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism NF-kappa B signaling pathway 0 0.795454545 0.427799228 kegg kegg NA NA no up no no no no Arginine biosynthesis NF-kappa B signaling pathway 0.495652174 0.739130435 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism NF-kappa B signaling pathway 0 -0.490118577 -0.570913771 kegg kegg NA NA no no no no no no Biosynthesis of amino acids NF-kappa B signaling pathway 0 0.429841897 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors NF-kappa B signaling pathway -0.451304348 -0.457509881 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids NF-kappa B signaling pathway 0 -0.425889328 -0.654311454 kegg kegg NA NA no no no no no no Butanoate metabolism NF-kappa B signaling pathway 0 -0.756916996 -0.55984556 kegg kegg NA NA no no no no no no cAMP signaling pathway NF-kappa B signaling pathway 0 0.54743083 0.463320463 yes kegg kegg NA NA no up up no no no cGMP-PKG signaling pathway NF-kappa B signaling pathway 0 0.507905138 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway NF-kappa B signaling pathway 0 0.538537549 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) NF-kappa B signaling pathway 0 -0.759881423 0 kegg kegg NA NA no no no no no no Collinsella NF-kappa B signaling pathway 0 0 -0.404741474 Genus kegg 0.128 NA no no no no no no Cysteine and methionine metabolism NF-kappa B signaling pathway 0 -0.812252964 -0.402059202 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction NF-kappa B signaling pathway 0 0 -0.512998713 kegg kegg NA NA no no no no no no DNA replication NF-kappa B signaling pathway 0 -0.713438735 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 NF-kappa B signaling pathway 0 -0.803359684 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes NF-kappa B signaling pathway 0 -0.846837945 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance NF-kappa B signaling pathway 0 -0.646245059 0 kegg kegg NA NA no no no no no no ErbB signaling pathway NF-kappa B signaling pathway 0.502608696 0.606719368 0.402831403 kegg kegg NA NA no no no no no no Fatty acid biosynthesis NF-kappa B signaling pathway 0.473913043 0.738142292 0.477477477 kegg kegg NA NA no no no no no no Fatty acid degradation NF-kappa B signaling pathway 0.411304348 0.53458498 0 kegg kegg NA NA no no no no no no Fatty acid elongation NF-kappa B signaling pathway 0 -0.533596838 -0.602316602 kegg kegg NA NA no no no no no no Fructose and mannose metabolism NF-kappa B signaling pathway 0 0.581027668 0 kegg kegg NA NA no no no no no no Galactose metabolism NF-kappa B signaling pathway 0 0.533596838 0 kegg kegg NA NA no no no no no no Glutathione metabolism NF-kappa B signaling pathway -0.612173913 -0.661067194 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism NF-kappa B signaling pathway 0.729565217 0.59486166 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism NF-kappa B signaling pathway 0.500869565 0.519762846 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" NF-kappa B signaling pathway -0.535652174 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis NF-kappa B signaling pathway 0 -0.766798419 -0.452252252 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate NF-kappa B signaling pathway 0.473913043 0.898221344 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series NF-kappa B signaling pathway -0.56 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series NF-kappa B signaling pathway 0 0.558300395 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism NF-kappa B signaling pathway 0.537391304 0.72826087 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism NF-kappa B signaling pathway 0.56173913 0.454545455 0 kegg kegg NA NA no no no no no no Lachnospira NF-kappa B signaling pathway 0 -0.51791452 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Lysine degradation NF-kappa B signaling pathway 0.457391304 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 NF-kappa B signaling pathway 0 -0.808300395 -0.427799228 kegg kegg NA NA no no no no no no Mismatch repair NF-kappa B signaling pathway 0 -0.669960474 -0.542857143 kegg kegg NA NA no no no no no no N-Glycan biosynthesis NF-kappa B signaling pathway 0 -0.665019763 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism NF-kappa B signaling pathway 0.450434783 0.736166008 0.462033462 kegg kegg NA NA no no no no no no Nitrogen metabolism NF-kappa B signaling pathway 0 0.693675889 0 kegg kegg NA NA no no no no no no Non-homologous end-joining NF-kappa B signaling pathway 0 -0.651185771 -0.489060489 kegg kegg NA NA no no no no no no Nucleotide excision repair NF-kappa B signaling pathway 0 -0.627470356 -0.472329472 kegg kegg NA NA no no no no no no One carbon pool by folate NF-kappa B signaling pathway 0 -0.638339921 0 kegg kegg NA NA no no no no no no Oscillospira NF-kappa B signaling pathway 0 0.433794466 0 LPS-producing Genus kegg 0.62 NA no no no no no no Other glycan degradation NF-kappa B signaling pathway 0.482608696 0.568181818 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation NF-kappa B signaling pathway 0 -0.723320158 -0.422136422 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis NF-kappa B signaling pathway 0.525217391 0.621541502 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions NF-kappa B signaling pathway 0 -0.73715415 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism NF-kappa B signaling pathway 0 -0.704545455 -0.503732304 kegg kegg NA NA no no no no no no Platinum drug resistance NF-kappa B signaling pathway 0.448695652 0 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism NF-kappa B signaling pathway -0.533043478 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway NF-kappa B signaling pathway 0 0.688735178 0.407722008 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis NF-kappa B signaling pathway 0 -0.586956522 -0.501415701 kegg kegg NA NA no no no no no no Propanoate metabolism NF-kappa B signaling pathway 0 -0.783596838 0 kegg kegg NA NA no no no no no no Proteasome NF-kappa B signaling pathway 0 -0.714426877 0 kegg kegg NA NA no no no no no no Protein export NF-kappa B signaling pathway 0 -0.751976285 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism NF-kappa B signaling pathway 0 -0.650197628 0 kegg kegg NA NA no no no no no no Pyruvate metabolism NF-kappa B signaling pathway 0 -0.833992095 -0.427541828 kegg kegg NA NA no no no no no no Rap1 signaling pathway NF-kappa B signaling pathway -0.408695652 -0.475296443 0 kegg kegg NA NA no no no no no no Ras signaling pathway NF-kappa B signaling pathway 0 -0.684782609 0 yes kegg kegg NA NA no up up no no no Retinol metabolism NF-kappa B signaling pathway 0 -0.489130435 0 kegg kegg NA NA no no no no no no Ribosome NF-kappa B signaling pathway 0 -0.743083004 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes NF-kappa B signaling pathway 0 -0.460474308 0 kegg kegg NA NA no no no no no no RNA degradation NF-kappa B signaling pathway 0 -0.615612648 0 kegg kegg NA NA no no no no no no RNA polymerase NF-kappa B signaling pathway 0 -0.578063241 0 kegg kegg NA NA no no no no no no RNA transport NF-kappa B signaling pathway 0 -0.591897233 0 kegg kegg NA NA no no no no no no Roseburia NF-kappa B signaling pathway -0.450434783 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Sarcina NF-kappa B signaling pathway 0 0.422326513 0 Genus kegg 0.0703 NA no no no no no no Selenocompound metabolism NF-kappa B signaling pathway 0.429565217 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism NF-kappa B signaling pathway 0 0.647233202 0 kegg kegg NA NA no no no no no no Steroid biosynthesis NF-kappa B signaling pathway 0 -0.661067194 -0.57014157 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis NF-kappa B signaling pathway 0 -0.613636364 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies NF-kappa B signaling pathway 0 -0.562252964 -0.472329472 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism NF-kappa B signaling pathway 0.545217391 0.658102767 0 kegg kegg NA NA no no no no no no Thiamine metabolism NF-kappa B signaling pathway 0 -0.600790514 0 kegg kegg NA NA no no no no no no Tryptophan metabolism NF-kappa B signaling pathway 0 -0.625494071 0 kegg kegg NA NA no up no no no no Tyrosine metabolism NF-kappa B signaling pathway 0 -0.789525692 -0.708622909 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis NF-kappa B signaling pathway 0 -0.549407115 -0.445559846 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" NF-kappa B signaling pathway 0 -0.669960474 -0.545688546 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis NF-kappa B signaling pathway 0 -0.488142292 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor NF-kappa B signaling pathway 0 0 -0.434749035 kegg kegg NA NA no no no no no no 2-hydroxyphenylacetic acid+urine Nicotinamide+urine 0.57593985 0.58245614 0.490598291 urine_cometabolism urine_cometabolism 0.763 0.721 no no no no no no 4-hydroxybenzoic acid+urine Nicotinamide+urine 0 0.59122807 0 urine_cometabolism urine_cometabolism 0.52 0.721 no no no no no no Homovanillic acid+urine Nicotinamide+urine 0 0.607017544 0.557606838 urine_cometabolism urine_cometabolism 0.45 0.721 no no no no no no Kynurenic acid+urine Nicotinamide+urine 0 -0.559649123 0 urine_cometabolism urine_cometabolism 0.296 0.721 no no no no no no "Alanine, aspartate and glutamate metabolism" Nicotinate and nicotinamide metabolism 0.828695652 0.90513834 0.723294723 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Nicotinate and nicotinamide metabolism 0 0.650197628 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Nicotinate and nicotinamide metabolism 0.793913043 0.859683794 0.755984556 kegg kegg NA NA no up no no no no Arginine biosynthesis Nicotinate and nicotinamide metabolism 0.87826087 0.89229249 0.763706564 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Nicotinate and nicotinamide metabolism 0 -0.421936759 0 kegg kegg NA NA no no no no no no Butanoate metabolism Nicotinate and nicotinamide metabolism 0 -0.745059289 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Nicotinate and nicotinamide metabolism 0 -0.740118577 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Nicotinate and nicotinamide metabolism 0 -0.711462451 -0.536936937 kegg kegg NA NA no no no no no no Ether lipid metabolism Nicotinate and nicotinamide metabolism -0.51826087 -0.592885375 -0.43963964 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Nicotinate and nicotinamide metabolism 0.903478261 0.93972332 0.772200772 kegg kegg NA NA no no no no no no Fatty acid degradation Nicotinate and nicotinamide metabolism 0.740869565 0.697628458 0 kegg kegg NA NA no no no no no no Galactose metabolism Nicotinate and nicotinamide metabolism 0 0.624505929 0 kegg kegg NA NA no no no no no no Glutathione metabolism Nicotinate and nicotinamide metabolism 0 -0.654150198 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Nicotinate and nicotinamide metabolism -0.493043478 -0.436758893 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Nicotinate and nicotinamide metabolism 0 -0.549407115 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Nicotinate and nicotinamide metabolism 0.760869565 0.752964427 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Nicotinate and nicotinamide metabolism 0 -0.56916996 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Nicotinate and nicotinamide metabolism -0.491304348 -0.468379447 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Nicotinate and nicotinamide metabolism 0 0.5 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Nicotinate and nicotinamide metabolism 0 -0.5 -0.441441441 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Nicotinate and nicotinamide metabolism 0.800869565 0.898221344 0.833204633 kegg kegg NA NA no no no no no no Lysine degradation Nicotinate and nicotinamide metabolism 0 0 -0.458172458 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Nicotinate and nicotinamide metabolism 0 0 -0.447619048 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Nicotinate and nicotinamide metabolism -0.513043478 -0.890316206 -0.6002574 kegg kegg NA NA no no no no no no One carbon pool by folate Nicotinate and nicotinamide metabolism 0 -0.65513834 -0.619047619 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Nicotinate and nicotinamide metabolism 0 0 -0.448133848 kegg kegg NA NA no no no no no no Oxidative phosphorylation Nicotinate and nicotinamide metabolism 0 -0.726284585 -0.475418275 kegg kegg NA NA no no no no no no Paraprevotella Nicotinate and nicotinamide metabolism 0 -0.498195609 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Nicotinate and nicotinamide metabolism 0 -0.872529644 -0.522007722 kegg kegg NA NA no no no no no no Pentose phosphate pathway Nicotinate and nicotinamide metabolism 0.486956522 0.756916996 0.819047619 kegg kegg NA NA no no no no no no Phenylalanine metabolism Nicotinate and nicotinamide metabolism 0 -0.592885375 0 kegg kegg NA NA no no no no no no Prevotella Nicotinate and nicotinamide metabolism 0 0.450312019 0 acetate-producing Genus kegg 0.287 NA no no no no no no Propanoate metabolism Nicotinate and nicotinamide metabolism 0 -0.638339921 0 kegg kegg NA NA no no no no no no Purine metabolism Nicotinate and nicotinamide metabolism 0 -0.516798419 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Nicotinate and nicotinamide metabolism 0 -0.651185771 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Nicotinate and nicotinamide metabolism 0 -0.77173913 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Nicotinate and nicotinamide metabolism 0.662608696 0.882411067 0.501415701 kegg kegg NA NA no no no no no no Steroid biosynthesis Nicotinate and nicotinamide metabolism -0.429565217 -0.415019763 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Nicotinate and nicotinamide metabolism 0 -0.543478261 -0.415958816 kegg kegg NA NA no no no no no no Thiamine metabolism Nicotinate and nicotinamide metabolism 0 -0.641304348 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Nicotinate and nicotinamide metabolism 0 -0.572134387 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Nicotinate and nicotinamide metabolism 0 -0.523715415 -0.416216216 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Nicotinate and nicotinamide metabolism 0 -0.660079051 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Nicotinate and nicotinamide metabolism 0 -0.787549407 -0.401801802 kegg kegg NA NA no no no no no no ABC transporters Nicotine addiction 0 0.809288538 0 kegg kegg NA NA no up up no up up Antifolate resistance Nicotine addiction 0 0.566205534 0 kegg kegg NA NA no no no no up up Antigen processing and presentation Nicotine addiction 0 -0.686758893 0 kegg kegg NA NA no no no no up up Apelin signaling pathway Nicotine addiction -0.433043478 0 0 kegg kegg NA NA no no no no up up Apoptosis - multiple species Nicotine addiction 0 0.588932806 0 kegg kegg NA NA no no no no up up Autophagy - other Nicotine addiction 0 0.444664032 0 kegg kegg NA NA no no no no up up B cell receptor signaling pathway Nicotine addiction 0.460869565 0 0.577091377 kegg kegg NA NA no no no no up up Base excision repair Nicotine addiction 0 0.531620553 -0.413384813 kegg kegg NA NA no no no no up up beta-Alanine metabolism Nicotine addiction 0 0 -0.584041184 kegg kegg NA NA no no no no up up Biosynthesis of unsaturated fatty acids Nicotine addiction 0 0 -0.596653797 kegg kegg NA NA no no no no up up Butanoate metabolism Nicotine addiction 0 0 -0.585328185 kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway Nicotine addiction 0 0 0.492406692 kegg kegg NA NA no no no no up up cAMP signaling pathway Nicotine addiction 0 0 0.434234234 yes kegg kegg NA NA no up up no up up Carbohydrate digestion and absorption Nicotine addiction 0 0.544466403 0 kegg kegg NA NA no no no no up up Carbon metabolism Nicotine addiction 0 -0.566205534 0 kegg kegg NA NA no no no no up up Cell cycle Nicotine addiction 0 0.503952569 0 kegg kegg NA NA no no no no up up Cholesterol metabolism Nicotine addiction 0 -0.567193676 0 yes kegg kegg NA NA no no up no up up Circadian rhythm Nicotine addiction 0 0.580039526 0 kegg kegg NA NA no no no no up up Collecting duct acid secretion Nicotine addiction 0 -0.424901186 0 kegg kegg NA NA no no no no up up Cortisol synthesis and secretion Nicotine addiction 0 0.448616601 0 kegg kegg NA NA no no up no up up Cushing syndrome Nicotine addiction 0 0.518774704 0 kegg kegg NA NA no no up no up up Cysteine and methionine metabolism Nicotine addiction -0.46 0 -0.541312741 kegg kegg NA NA no no no no up up Cytosolic DNA-sensing pathway Nicotine addiction 0 0 0.507593308 kegg kegg NA NA no no no no up up Drug metabolism - cytochrome P450 Nicotine addiction -0.482608696 0 0 kegg kegg NA NA no no no no up up Endocrine resistance Nicotine addiction 0 0.476284585 0 kegg kegg NA NA no no no no up up ErbB signaling pathway Nicotine addiction 0 0.611660079 0 kegg kegg NA NA no no no no up up Estrogen signaling pathway Nicotine addiction 0 0 -0.645559846 kegg kegg NA NA no no no no up up Fanconi anemia pathway Nicotine addiction 0 0.609683794 0 kegg kegg NA NA no no no no up up Fatty acid elongation Nicotine addiction 0 -0.479249012 -0.728185328 kegg kegg NA NA no no no no up up Focal adhesion Nicotine addiction 0 -0.459486166 0 kegg kegg NA NA no up up no up up FoxO signaling pathway Nicotine addiction 0 0.455533597 0 kegg kegg NA NA no no no no up up Glycerolipid metabolism Nicotine addiction 0 0.71541502 0 kegg kegg NA NA no no up no up up Glycerophospholipid metabolism Nicotine addiction 0 0.723320158 0 kegg kegg NA NA no no up no up up Glycolysis / Gluconeogenesis Nicotine addiction 0 0 -0.458687259 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate Nicotine addiction 0 0 0.40952381 kegg kegg NA NA no no no no up up Glycosaminoglycan degradation Nicotine addiction 0 -0.451581028 0 kegg kegg NA NA no no up no up up Glycosphingolipid biosynthesis - lacto and neolacto series Nicotine addiction 0 0 0.495238095 kegg kegg NA NA no no no no up up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Nicotine addiction 0 0.625494071 0 kegg kegg NA NA no no no no up up GnRH secretion Nicotine addiction 0 0.652173913 0 kegg kegg NA NA no up up no up up "Growth hormone synthesis, secretion and action" Nicotine addiction 0 0.510869565 0 kegg kegg NA NA no no no no up up Hedgehog signaling pathway Nicotine addiction 0 0.627470356 0 kegg kegg NA NA no no no no up up Hematopoietic cell lineage Nicotine addiction 0 0 -0.497297297 kegg kegg NA NA no no no no up up Homologous recombination Nicotine addiction 0 0.691699605 0 kegg kegg NA NA no no no no up up IL-17 signaling pathway Nicotine addiction 0 -0.419960474 0 kegg kegg NA NA no no no no up up Inositol phosphate metabolism Nicotine addiction 0 0.683794466 0 kegg kegg NA NA no no no no up up Insulin resistance Nicotine addiction 0 0 0.475675676 kegg kegg NA NA no no no no up up Insulin signaling pathway Nicotine addiction -0.435652174 0 0 kegg kegg NA NA no no no no up up JAK-STAT signaling pathway Nicotine addiction 0 0.442687747 0 kegg kegg NA NA no no no no up up Leukocyte transendothelial migration Nicotine addiction 0 -0.659090909 0 kegg kegg NA NA no no no no up up Linoleic acid metabolism Nicotine addiction -0.491304348 0 0 kegg kegg NA NA no no no no up up Longevity regulating pathway - multiple species Nicotine addiction 0 0 -0.604118404 kegg kegg NA NA no no no no up up Lysine degradation Nicotine addiction 0 0.725296443 0 kegg kegg NA NA no no no no up up Lysosome Nicotine addiction 0 -0.626482213 0 kegg kegg NA NA no no no no up up Mannose type O-glycan biosynthesis Nicotine addiction 0 0.639328063 0 kegg kegg NA NA no no no no up up MAPK signaling pathway Nicotine addiction 0 0.453557312 0 kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 Nicotine addiction -0.496521739 0 0 kegg kegg NA NA no no no no up up Mismatch repair Nicotine addiction 0 0 -0.526898327 kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis Nicotine addiction -0.408695652 0 0 kegg kegg NA NA no no no no up up Neuroactive ligand-receptor interaction Nicotine addiction 0 -0.5 0 kegg kegg NA NA up up up no up up Neurotrophin signaling pathway Nicotine addiction 0 0 0.583526384 kegg kegg NA NA no no no no up up NF-kappa B signaling pathway Nicotine addiction 0.429565217 0 0.413899614 kegg kegg NA NA no no no no up up Non-homologous end-joining Nicotine addiction 0 0 -0.607722008 kegg kegg NA NA no no no no up up Notch signaling pathway Nicotine addiction 0 0.483201581 0 kegg kegg NA NA no no no no up up Nucleotide excision repair Nicotine addiction 0 0 -0.473616474 kegg kegg NA NA no no no no up up Oocyte meiosis Nicotine addiction -0.548695652 0 0 kegg kegg NA NA no no no no up up Other glycan degradation Nicotine addiction 0 0.524703557 0 kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis Nicotine addiction 0 0.83201581 0 kegg kegg NA NA no no no no up up Oxytocin signaling pathway Nicotine addiction 0 -0.526679842 0 kegg kegg NA NA no no no no up up p53 signaling pathway Nicotine addiction 0 0.666996047 0 kegg kegg NA NA no no no no up up Pentose and glucuronate interconversions Nicotine addiction -0.425217391 0 0 kegg kegg NA NA no no no no up up Pentose phosphate pathway Nicotine addiction 0 -0.41798419 0 kegg kegg NA NA no no no no up up Phagosome Nicotine addiction 0 -0.421936759 0 kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system Nicotine addiction 0 0.52173913 0 kegg kegg NA NA no no no no up up Phototransduction Nicotine addiction -0.565217391 -0.579051383 0 kegg kegg NA NA no no no no up up Platelet activation Nicotine addiction 0 -0.445652174 0 kegg kegg NA NA no no no no up up Platinum drug resistance Nicotine addiction 0 0.693675889 0 kegg kegg NA NA no no no no up up Primary bile acid biosynthesis Nicotine addiction 0 0 -0.568339768 kegg kegg NA NA no no no no up up Progesterone-mediated oocyte maturation Nicotine addiction 0 0.7756917 0 kegg kegg NA NA no no no no up up Propanoate metabolism Nicotine addiction -0.411304348 0 -0.572972973 kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation Nicotine addiction -0.42 0 -0.448133848 kegg kegg NA NA no no no no up up Pyruvate metabolism Nicotine addiction -0.428695652 0 -0.572458172 kegg kegg NA NA no no no no up up Ras signaling pathway Nicotine addiction -0.452173913 0 0 yes kegg kegg NA NA no up up no up up Regulation of actin cytoskeleton Nicotine addiction 0 -0.592885375 -0.480566281 kegg kegg NA NA no no no no up up Relaxin signaling pathway Nicotine addiction 0 0 0.486486486 kegg kegg NA NA no no no no up up Renin secretion Nicotine addiction -0.406086957 0 0 kegg kegg NA NA no no no no up up Renin-angiotensin system Nicotine addiction 0 -0.467391304 0 kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes Nicotine addiction 0 0.511857708 0 kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway Nicotine addiction 0 0 0.475418275 kegg kegg NA NA no no no no up up Selenocompound metabolism Nicotine addiction 0 0.664031621 0 kegg kegg NA NA no no no no up up Signaling pathways regulating pluripotency of stem cells Nicotine addiction 0 0.615612648 0 kegg kegg NA NA no no no no up up Spinocerebellar ataxia Nicotine addiction 0 0.52173913 0 kegg kegg NA NA no no no no up up Spliceosome Nicotine addiction 0 0.722332016 0 kegg kegg NA NA no no no no up up Steroid biosynthesis Nicotine addiction 0 0 -0.457142857 kegg kegg NA NA no no no no up up Synthesis and degradation of ketone bodies Nicotine addiction 0 0 -0.498841699 kegg kegg NA NA no no no no up up T cell receptor signaling pathway Nicotine addiction 0 0.472332016 0 kegg kegg NA NA no no no no up up Taurine and hypotaurine metabolism Nicotine addiction 0 0.748023715 0 kegg kegg NA NA no no no no up up Tight junction Nicotine addiction 0 -0.557312253 0 kegg kegg NA NA no no no no up up TNF signaling pathway Nicotine addiction 0 0 0.662033462 kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway Nicotine addiction 0 0 0.541055341 yes kegg kegg NA NA no no no no up up Tryptophan metabolism Nicotine addiction 0 0 -0.471299871 kegg kegg NA NA no up no no up up Type II diabetes mellitus Nicotine addiction 0 0.451581028 0 kegg kegg NA NA no no no no up up Tyrosine metabolism Nicotine addiction 0 0 -0.546460746 kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" Nicotine addiction 0 0 -0.594337194 kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor Nicotine addiction 0 -0.468379447 0 kegg kegg NA NA no no no no up up "Alanine, aspartate and glutamate metabolism" Nitrogen metabolism 0.825217391 0.915019763 0.857400257 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Nitrogen metabolism 0 0.510869565 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Nitrogen metabolism 0 0 0.402831403 kegg kegg NA NA no no no no no no Arginine and proline metabolism Nitrogen metabolism 0.684347826 0.850790514 0.650965251 kegg kegg NA NA no up no no no no Arginine biosynthesis Nitrogen metabolism 0.869565217 0.947628458 0.914285714 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Nitrogen metabolism 0 -0.619565217 -0.48957529 kegg kegg NA NA no no no no no no Butanoate metabolism Nitrogen metabolism 0 -0.734189723 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Nitrogen metabolism -0.41826087 -0.71541502 -0.518404118 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Nitrogen metabolism 0 -0.62055336 -0.487516088 kegg kegg NA NA no no no no no no Ether lipid metabolism Nitrogen metabolism -0.533043478 -0.570158103 -0.510682111 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Nitrogen metabolism 0.751304348 0.846837945 0.63011583 kegg kegg NA NA no no no no no no Fatty acid degradation Nitrogen metabolism 0.492173913 0.592885375 0 kegg kegg NA NA no no no no no no Folate biosynthesis Nitrogen metabolism 0 -0.776679842 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Nitrogen metabolism 0 0 -0.537451737 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Nitrogen metabolism 0 0 -0.508880309 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Nitrogen metabolism 0 0 0.446332046 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Nitrogen metabolism 0 -0.500988142 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Nitrogen metabolism 0.78173913 0.62944664 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Nitrogen metabolism 0 -0.710474308 -0.654568855 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Nitrogen metabolism 0 -0.533596838 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Nitrogen metabolism 0 -0.541501976 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Nitrogen metabolism 0.784347826 0.948616601 0.858687259 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Nitrogen metabolism 0 0 -0.49034749 kegg kegg NA NA no no no no no no Lysine degradation Nitrogen metabolism 0 0 -0.656628057 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Nitrogen metabolism 0 -0.442687747 -0.651222651 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Nitrogen metabolism -0.575652174 -0.885375494 -0.656885457 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Nitrogen metabolism 0.774782609 0.838932806 0.682882883 kegg kegg NA NA no no no no no no One carbon pool by folate Nitrogen metabolism -0.565217391 -0.693675889 -0.748262548 kegg kegg NA NA no no no no no no Other glycan degradation Nitrogen metabolism 0 0 -0.513256113 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Nitrogen metabolism 0 0 -0.523552124 kegg kegg NA NA no no no no no no Oxidative phosphorylation Nitrogen metabolism -0.467826087 -0.624505929 -0.443243243 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Nitrogen metabolism 0.559130435 0.706521739 0.485714286 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Nitrogen metabolism -0.453913043 -0.868577075 -0.71016731 kegg kegg NA NA no no no no no no Pentose phosphate pathway Nitrogen metabolism 0.611304348 0.580039526 0.617245817 kegg kegg NA NA no no no no no no Phenylalanine metabolism Nitrogen metabolism 0 -0.706521739 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Nitrogen metabolism 0 0 0.438352638 kegg kegg NA NA no no no no no no Propanoate metabolism Nitrogen metabolism 0 -0.539525692 -0.403861004 kegg kegg NA NA no no no no no no Pyrimidine metabolism Nitrogen metabolism 0 -0.609683794 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Nitrogen metabolism 0 -0.640316206 0 kegg kegg NA NA no no no no no no Retinol metabolism Nitrogen metabolism 0 0 -0.437580438 kegg kegg NA NA no no no no no no Selenocompound metabolism Nitrogen metabolism 0 0 -0.458687259 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Nitrogen metabolism 0.615652174 0.687747036 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Nitrogen metabolism -0.606956522 -0.43083004 -0.44967825 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Nitrogen metabolism 0 -0.469367589 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Nitrogen metabolism 0 -0.498023715 -0.484427284 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Nitrogen metabolism -0.484347826 0 -0.424453024 kegg kegg NA NA no no no no no no Thiamine metabolism Nitrogen metabolism 0 -0.416996047 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Nitrogen metabolism 0 -0.530632411 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Nitrogen metabolism 0 -0.571146245 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Nitrogen metabolism 0 -0.570158103 -0.490862291 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Nitrogen metabolism 0 -0.7243083 -0.507078507 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Nitrogen metabolism 0 -0.766798419 -0.599227799 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism NOD-like receptor signaling pathway 0 -0.516798419 0 kegg kegg NA NA no no no no no no Adherens junction NOD-like receptor signaling pathway 0 -0.690711462 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes NOD-like receptor signaling pathway 0 -0.663043478 -0.407722008 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" NOD-like receptor signaling pathway 0.684347826 0.788537549 0.562676963 kegg kegg NA NA no no no no no no Alistipes NOD-like receptor signaling pathway -0.440178869 0 0 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism NOD-like receptor signaling pathway 0.446086957 0.562252964 0 kegg kegg NA NA no no no no no no AMPK signaling pathway NOD-like receptor signaling pathway -0.609565217 0 0 kegg kegg NA NA no no no no no no Antifolate resistance NOD-like receptor signaling pathway 0 -0.437747036 -0.421621622 kegg kegg NA NA no no no no no no Apelin signaling pathway NOD-like receptor signaling pathway 0 -0.684782609 0 kegg kegg NA NA no no no no no no Apoptosis NOD-like receptor signaling pathway 0.489565217 0.807312253 0.436808237 kegg kegg NA NA no no no no no no Arginine and proline metabolism NOD-like receptor signaling pathway 0.770434783 0.78458498 0 kegg kegg NA NA no up no no no no Arginine biosynthesis NOD-like receptor signaling pathway 0.713913043 0.763833992 0.534362934 kegg kegg NA NA no no no no no no Autophagy - animal NOD-like receptor signaling pathway 0.505217391 0.843873518 0 kegg kegg NA NA no no no no no no Autophagy - other NOD-like receptor signaling pathway 0 0.459486166 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids NOD-like receptor signaling pathway 0.44 0.672924901 0.440669241 kegg kegg NA NA no no no no no no Biosynthesis of cofactors NOD-like receptor signaling pathway -0.565217391 -0.589920949 0 kegg kegg NA NA no no no no no no Butanoate metabolism NOD-like receptor signaling pathway 0 -0.623517787 0 kegg kegg NA NA no no no no no no Calcium signaling pathway NOD-like receptor signaling pathway -0.477391304 -0.579051383 0 kegg kegg NA NA no up up no no no Cardiac muscle contraction NOD-like receptor signaling pathway 0 -0.756916996 0 kegg kegg NA NA no no up no no no Cell adhesion molecules NOD-like receptor signaling pathway 0 0.561264822 0 kegg kegg NA NA no no no no no no Cell cycle NOD-like receptor signaling pathway 0 -0.635375494 0 kegg kegg NA NA no no no no no no Cellular senescence NOD-like receptor signaling pathway 0 0.639328063 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway NOD-like receptor signaling pathway 0.563478261 0.699604743 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway NOD-like receptor signaling pathway 0 0.516798419 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) NOD-like receptor signaling pathway 0 -0.638339921 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades NOD-like receptor signaling pathway 0.535652174 0.562252964 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism NOD-like receptor signaling pathway 0 -0.616600791 0 kegg kegg NA NA no no no no no no DNA replication NOD-like receptor signaling pathway 0 -0.712450593 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 NOD-like receptor signaling pathway 0 -0.746047431 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes NOD-like receptor signaling pathway 0 -0.699604743 0 kegg kegg NA NA no no no no no no ECM-receptor interaction NOD-like receptor signaling pathway -0.405217391 -0.462450593 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance NOD-like receptor signaling pathway 0 -0.548418972 0 kegg kegg NA NA no no no no no no Endocrine resistance NOD-like receptor signaling pathway -0.60173913 0 0 kegg kegg NA NA no no no no no no Endocytosis NOD-like receptor signaling pathway 0 0.583992095 0 kegg kegg NA NA no no no no no no ErbB signaling pathway NOD-like receptor signaling pathway 0 0.432806324 0 kegg kegg NA NA no no no no no no Ether lipid metabolism NOD-like receptor signaling pathway -0.568695652 -0.52173913 -0.493436293 kegg kegg NA NA no no no no no no Fatty acid biosynthesis NOD-like receptor signaling pathway 0.809565217 0.770750988 0.597425997 kegg kegg NA NA no no no no no no Fatty acid degradation NOD-like receptor signaling pathway 0.7 0.664031621 0 kegg kegg NA NA no no no no no no Fatty acid metabolism NOD-like receptor signaling pathway 0.649565217 0.600790514 0 kegg kegg NA NA no no no no no no Focal adhesion NOD-like receptor signaling pathway 0 -0.631422925 0 kegg kegg NA NA no up up no no no Folate biosynthesis NOD-like receptor signaling pathway 0 -0.455533597 0 kegg kegg NA NA no no no no no no FoxO signaling pathway NOD-like receptor signaling pathway 0.545217391 0.567193676 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism NOD-like receptor signaling pathway 0 0.489130435 0 kegg kegg NA NA no no no no no no Galactose metabolism NOD-like receptor signaling pathway 0 0.564229249 0 kegg kegg NA NA no no no no no no Gap junction NOD-like receptor signaling pathway -0.557391304 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism NOD-like receptor signaling pathway -0.474782609 -0.749011858 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" NOD-like receptor signaling pathway -0.669565217 -0.493083004 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis NOD-like receptor signaling pathway 0 -0.460474308 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate NOD-like receptor signaling pathway 0.608695652 0.726284585 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin NOD-like receptor signaling pathway 0 -0.425889328 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate NOD-like receptor signaling pathway -0.59826087 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation NOD-like receptor signaling pathway 0 0.459486166 0 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism NOD-like receptor signaling pathway 0.653913043 0.796442688 0.481853282 kegg kegg NA NA no no no no no no HIF-1 signaling pathway NOD-like receptor signaling pathway 0 -0.509881423 0 kegg kegg NA NA no no no no no no Hippo signaling pathway NOD-like receptor signaling pathway 0 -0.705533597 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species NOD-like receptor signaling pathway 0.49826087 0.704545455 0 kegg kegg NA NA no no no no no no Lachnospira NOD-like receptor signaling pathway 0 -0.421546838 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Linoleic acid metabolism NOD-like receptor signaling pathway 0 -0.41798419 -0.405920206 kegg kegg NA NA no no no no no no Lysosome NOD-like receptor signaling pathway 0.520869565 0.507905138 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis NOD-like receptor signaling pathway -0.422608696 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 NOD-like receptor signaling pathway 0 -0.694664032 0 kegg kegg NA NA no no no no no no Mismatch repair NOD-like receptor signaling pathway 0 -0.597826087 0 kegg kegg NA NA no no no no no no Mitophagy - animal NOD-like receptor signaling pathway -0.646086957 -0.496047431 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway NOD-like receptor signaling pathway 0 -0.563241107 0 kegg kegg NA NA no no no no no no mTOR signaling pathway NOD-like receptor signaling pathway 0 -0.508893281 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis NOD-like receptor signaling pathway -0.515652174 -0.766798419 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction NOD-like receptor signaling pathway 0.453043478 0.493083004 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation NOD-like receptor signaling pathway 0.649565217 0.527667984 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway NOD-like receptor signaling pathway 0.517391304 0.83201581 0.448648649 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism NOD-like receptor signaling pathway 0.872173913 0.766798419 0.455855856 kegg kegg NA NA no no no no no no Nitrogen metabolism NOD-like receptor signaling pathway 0.600869565 0.68972332 0.432947233 kegg kegg NA NA no no no no no no Nucleotide excision repair NOD-like receptor signaling pathway 0 -0.651185771 0 kegg kegg NA NA no no no no no no One carbon pool by folate NOD-like receptor signaling pathway 0 -0.699604743 0 kegg kegg NA NA no no no no no no Oocyte meiosis NOD-like receptor signaling pathway 0 -0.551383399 0 kegg kegg NA NA no no no no no no Oscillospira NOD-like receptor signaling pathway 0 0 0.435521236 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation NOD-like receptor signaling pathway 0.735652174 0.885375494 0.515057915 kegg kegg NA NA no no no no no no Other glycan degradation NOD-like receptor signaling pathway 0 0.438735178 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation NOD-like receptor signaling pathway 0 -0.767786561 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis NOD-like receptor signaling pathway 0.797391304 0.723320158 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions NOD-like receptor signaling pathway 0 -0.673913043 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway NOD-like receptor signaling pathway 0.435652174 0.551383399 0 kegg kegg NA NA no no no no no no Peroxisome NOD-like receptor signaling pathway 0.735652174 0.68083004 0.495495495 kegg kegg NA NA no no no no no no Phagosome NOD-like receptor signaling pathway 0 0.523715415 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism NOD-like receptor signaling pathway 0 -0.623517787 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway NOD-like receptor signaling pathway 0 0.578063241 0 kegg kegg NA NA no up up no no no Platelet activation NOD-like receptor signaling pathway 0 -0.623517787 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism NOD-like receptor signaling pathway -0.599130435 -0.455533597 0 kegg kegg NA NA no no no no no no PPAR signaling pathway NOD-like receptor signaling pathway 0.706956522 0.834980237 0 kegg kegg NA NA no no no no no no Propanoate metabolism NOD-like receptor signaling pathway 0 -0.581027668 0 kegg kegg NA NA no no no no no no Proteasome NOD-like receptor signaling pathway 0 -0.476284585 0 kegg kegg NA NA no no no no no no Protein export NOD-like receptor signaling pathway -0.442608696 -0.658102767 -0.441441441 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum NOD-like receptor signaling pathway -0.712173913 -0.694664032 0 kegg kegg NA NA no no no no no no Purine metabolism NOD-like receptor signaling pathway -0.531304348 -0.5 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism NOD-like receptor signaling pathway 0 -0.699604743 0 kegg kegg NA NA no no no no no no Pyruvate metabolism NOD-like receptor signaling pathway 0 -0.690711462 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway NOD-like receptor signaling pathway 0 -0.444664032 0 kegg kegg NA NA no no no no no no Ras signaling pathway NOD-like receptor signaling pathway 0 -0.740118577 -0.455341055 yes kegg kegg NA NA no up up no no no Renin-angiotensin system NOD-like receptor signaling pathway 0.64173913 0.657114625 0 kegg kegg NA NA no no no no no no Retinol metabolism NOD-like receptor signaling pathway 0 -0.503952569 0 kegg kegg NA NA no no no no no no Ribosome NOD-like receptor signaling pathway -0.548695652 -0.670948617 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes NOD-like receptor signaling pathway 0 -0.513833992 0 kegg kegg NA NA no no no no no no RNA degradation NOD-like receptor signaling pathway -0.419130435 -0.67687747 0 kegg kegg NA NA no no no no no no RNA polymerase NOD-like receptor signaling pathway 0 -0.635375494 -0.488288288 kegg kegg NA NA no no no no no no Ruminococcus NOD-like receptor signaling pathway -0.484347826 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no SNARE interactions in vesicular transport NOD-like receptor signaling pathway 0 0.606719368 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway NOD-like receptor signaling pathway 0 0.587944664 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism NOD-like receptor signaling pathway 0.674782609 0.730237154 0 kegg kegg NA NA no no no no no no Steroid biosynthesis NOD-like receptor signaling pathway -0.486086957 -0.529644269 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis NOD-like receptor signaling pathway 0 -0.508893281 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies NOD-like receptor signaling pathway 0 -0.580039526 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway NOD-like receptor signaling pathway -0.433913043 -0.633399209 0 kegg kegg NA NA no no no no no no Thiamine metabolism NOD-like receptor signaling pathway 0 -0.511857708 0 kegg kegg NA NA no no no no no no Tight junction NOD-like receptor signaling pathway 0 -0.561264822 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway NOD-like receptor signaling pathway 0.486086957 0.909090909 0 yes kegg kegg NA NA no no no no no no Tyrosine metabolism NOD-like receptor signaling pathway 0 -0.68083004 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis NOD-like receptor signaling pathway 0 -0.551383399 -0.461261261 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis NOD-like receptor signaling pathway -0.77826087 -0.586956522 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" NOD-like receptor signaling pathway 0 -0.605731225 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis NOD-like receptor signaling pathway 0 -0.583992095 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction NOD-like receptor signaling pathway -0.62 -0.7756917 0 kegg kegg NA NA no no no no no no VEGF signaling pathway NOD-like receptor signaling pathway 0 0.470355731 0 kegg kegg NA NA no no no no no no Wnt signaling pathway NOD-like receptor signaling pathway -0.519130435 -0.761857708 -0.420849421 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Non-alcoholic fatty liver disease -0.626086957 0 0 kegg kegg NA NA no no no no no no ABC transporters Non-alcoholic fatty liver disease -0.434782609 0 0 kegg kegg NA NA no up up no no no Adherens junction Non-alcoholic fatty liver disease 0 0.576086957 0.548777349 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Non-alcoholic fatty liver disease 0.784347826 0.813241107 0.474131274 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Non-alcoholic fatty liver disease -0.488695652 -0.697628458 -0.474131274 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Non-alcoholic fatty liver disease 0.636521739 0.750988142 0.515057915 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Non-alcoholic fatty liver disease -0.666086957 -0.710474308 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Non-alcoholic fatty liver disease -0.636521739 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Non-alcoholic fatty liver disease -0.640869565 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Non-alcoholic fatty liver disease 0 0.47826087 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Non-alcoholic fatty liver disease 0 0.660079051 0 kegg kegg NA NA no no no no no no Apoptosis Non-alcoholic fatty liver disease -0.46173913 -0.468379447 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Non-alcoholic fatty liver disease 0 -0.416996047 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Non-alcoholic fatty liver disease 0 -0.726284585 -0.555469755 kegg kegg NA NA no up no no no no Arginine biosynthesis Non-alcoholic fatty liver disease -0.513043478 -0.647233202 -0.418275418 kegg kegg NA NA no no no no no no Autophagy - animal Non-alcoholic fatty liver disease 0 -0.601778656 -0.559330759 kegg kegg NA NA no no no no no no Axon guidance Non-alcoholic fatty liver disease 0.522608696 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Non-alcoholic fatty liver disease 0 -0.529644269 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Non-alcoholic fatty liver disease -0.790434783 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Non-alcoholic fatty liver disease -0.839130435 -0.593873518 -0.416216216 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Non-alcoholic fatty liver disease -0.492173913 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Non-alcoholic fatty liver disease -0.662608696 0 0 kegg kegg NA NA no no no no no no Butyricimonas Non-alcoholic fatty liver disease 0.4325094 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no C-type lectin receptor signaling pathway Non-alcoholic fatty liver disease 0 -0.516798419 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Non-alcoholic fatty liver disease 0.760869565 0.73715415 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Non-alcoholic fatty liver disease 0.833913043 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Non-alcoholic fatty liver disease -0.809565217 0 -0.454826255 kegg kegg NA NA no no no no no no Cardiac muscle contraction Non-alcoholic fatty liver disease 0.965217391 0.92687747 0.902445302 kegg kegg NA NA no no up no no no Cell adhesion molecules Non-alcoholic fatty liver disease -0.582608696 0 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Non-alcoholic fatty liver disease 0 -0.570158103 0 kegg kegg NA NA no no no no no no Cholinergic synapse Non-alcoholic fatty liver disease 0 -0.472332016 0 kegg kegg NA NA no no no no no no Circadian entrainment Non-alcoholic fatty liver disease 0 0.526679842 0.412355212 kegg kegg NA NA no up up no no no Circadian rhythm Non-alcoholic fatty liver disease 0.73826087 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Non-alcoholic fatty liver disease -0.416521739 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Non-alcoholic fatty liver disease -0.576521739 -0.603754941 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Non-alcoholic fatty liver disease 0.420869565 0.433794466 0.461518662 kegg kegg NA NA no no up no no no Cytokine-cytokine receptor interaction Non-alcoholic fatty liver disease 0 -0.446640316 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Non-alcoholic fatty liver disease 0.706956522 0.695652174 0.431145431 kegg kegg NA NA no up no no no no Drug metabolism - other enzymes Non-alcoholic fatty liver disease -0.640869565 0.461462451 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Non-alcoholic fatty liver disease 0 0.590909091 0 kegg kegg NA NA no no no no no no Endocrine resistance Non-alcoholic fatty liver disease 0.462608696 0 0 kegg kegg NA NA no no no no no no Endocytosis Non-alcoholic fatty liver disease -0.466086957 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Non-alcoholic fatty liver disease 0.72 0.421936759 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Non-alcoholic fatty liver disease 0 -0.761857708 -0.591763192 kegg kegg NA NA no no no no no no Fatty acid degradation Non-alcoholic fatty liver disease -0.655652174 -0.853754941 -0.520978121 kegg kegg NA NA no no no no no no Fatty acid elongation Non-alcoholic fatty liver disease -0.623478261 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Non-alcoholic fatty liver disease -0.792173913 -0.830039526 -0.444272844 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Non-alcoholic fatty liver disease 0 -0.616600791 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Non-alcoholic fatty liver disease -0.475652174 -0.622529644 -0.503732304 kegg kegg NA NA no no no no no no Focal adhesion Non-alcoholic fatty liver disease 0 0.420948617 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Non-alcoholic fatty liver disease 0 -0.704545455 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Non-alcoholic fatty liver disease -0.785217391 -0.52173913 -0.544401544 kegg kegg NA NA no no no no no no GABAergic synapse Non-alcoholic fatty liver disease 0 -0.58201581 0 kegg kegg NA NA no up up no no no Galactose metabolism Non-alcoholic fatty liver disease -0.808695652 -0.808300395 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Non-alcoholic fatty liver disease 0.474782609 0.726284585 0 kegg kegg NA NA no no no no no no Glutathione metabolism Non-alcoholic fatty liver disease 0 0.657114625 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Non-alcoholic fatty liver disease 0 -0.591897233 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Non-alcoholic fatty liver disease -0.692173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Non-alcoholic fatty liver disease 0 -0.641304348 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Non-alcoholic fatty liver disease 0.537391304 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Non-alcoholic fatty liver disease -0.672173913 -0.652173913 -0.511196911 kegg kegg NA NA no no no no no no GnRH signaling pathway Non-alcoholic fatty liver disease 0.422608696 0.513833992 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Non-alcoholic fatty liver disease 0.571304348 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Non-alcoholic fatty liver disease 0 0.557312253 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Non-alcoholic fatty liver disease 0 0.562252964 0.515057915 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Non-alcoholic fatty liver disease 0 -0.668972332 0 kegg kegg NA NA no no no no no no Histidine metabolism Non-alcoholic fatty liver disease -0.446086957 -0.415019763 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Non-alcoholic fatty liver disease 0 -0.495059289 -0.45045045 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Non-alcoholic fatty liver disease 0.582608696 0.765810277 0.441956242 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Non-alcoholic fatty liver disease 0 -0.440711462 0 kegg kegg NA NA no no no no no no Insulin resistance Non-alcoholic fatty liver disease 0.414782609 -0.43972332 0 kegg kegg NA NA no no no no no no Insulin secretion Non-alcoholic fatty liver disease 0 0.558300395 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Non-alcoholic fatty liver disease 0 0.59486166 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Non-alcoholic fatty liver disease 0 -0.653162055 0 kegg kegg NA NA no no no no no no Long-term depression Non-alcoholic fatty liver disease 0.585217391 0.418972332 0 kegg kegg NA NA no no no no no no Long-term potentiation Non-alcoholic fatty liver disease 0.448695652 0 0 kegg kegg NA NA no no up no no no Lysosome Non-alcoholic fatty liver disease 0 0 -0.414414414 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Non-alcoholic fatty liver disease 0.491304348 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Non-alcoholic fatty liver disease 0 -0.723320158 0 kegg kegg NA NA no no no no no no Melanogenesis Non-alcoholic fatty liver disease 0.52 0.806324111 0.514800515 kegg kegg NA NA no no no no no no Mitophagy - animal Non-alcoholic fatty liver disease 0.567826087 0.812252964 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Non-alcoholic fatty liver disease 0.764347826 0.610671937 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Non-alcoholic fatty liver disease 0 0.590909091 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Non-alcoholic fatty liver disease 0 -0.473320158 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Non-alcoholic fatty liver disease 0 0.447628458 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Non-alcoholic fatty liver disease -0.487826087 0 0 kegg kegg NA NA no no no no no no Necroptosis Non-alcoholic fatty liver disease 0 0.446640316 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Non-alcoholic fatty liver disease 0 -0.496047431 -0.403603604 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Non-alcoholic fatty liver disease 0.57826087 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Non-alcoholic fatty liver disease -0.492173913 -0.488142292 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Non-alcoholic fatty liver disease 0 -0.621541502 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Non-alcoholic fatty liver disease 0 -0.661067194 -0.517117117 kegg kegg NA NA no no no no no no Nitrogen metabolism Non-alcoholic fatty liver disease -0.426086957 -0.527667984 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Non-alcoholic fatty liver disease 0 -0.663043478 -0.414157014 kegg kegg NA NA no no no no no no Non-homologous end-joining Non-alcoholic fatty liver disease -0.687826087 0 0 kegg kegg NA NA no no no no no no Olfactory transduction Non-alcoholic fatty liver disease 0 -0.57312253 0 kegg kegg NA NA no no no no no no Oocyte meiosis Non-alcoholic fatty liver disease 0.437391304 0 0 kegg kegg NA NA no no no no no no Oscillospira Non-alcoholic fatty liver disease 0 -0.510869565 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Non-alcoholic fatty liver disease 0 -0.658102767 -0.403861004 kegg kegg NA NA no no no no no no Other glycan degradation Non-alcoholic fatty liver disease 0 -0.461462451 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Non-alcoholic fatty liver disease 0 0.421936759 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Non-alcoholic fatty liver disease 0.966086957 0.950592885 0.902960103 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Non-alcoholic fatty liver disease 0 -0.738142292 -0.594079794 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Non-alcoholic fatty liver disease 0.713043478 0.795454545 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Non-alcoholic fatty liver disease -0.526086957 -0.530632411 -0.474646075 kegg kegg NA NA no no no no no no Peroxisome Non-alcoholic fatty liver disease -0.573043478 -0.713438735 0 kegg kegg NA NA no no no no no no Phagosome Non-alcoholic fatty liver disease -0.608695652 -0.415019763 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Non-alcoholic fatty liver disease 0.597391304 0 0 kegg kegg NA NA no no no no no no Platelet activation Non-alcoholic fatty liver disease 0 0.457509881 0.407207207 kegg kegg NA NA no no no no no no PPAR signaling pathway Non-alcoholic fatty liver disease 0 -0.526679842 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Non-alcoholic fatty liver disease -0.44173913 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Non-alcoholic fatty liver disease 0 -0.556324111 0 kegg kegg NA NA no no no no no no Protein export Non-alcoholic fatty liver disease 0.543478261 0.697628458 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Non-alcoholic fatty liver disease 0 0.555335968 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Non-alcoholic fatty liver disease -0.769565217 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Non-alcoholic fatty liver disease 0 0.446640316 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Non-alcoholic fatty liver disease 0 0 0.409266409 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Non-alcoholic fatty liver disease 0 0.423913043 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Non-alcoholic fatty liver disease 0.599130435 0 0 kegg kegg NA NA no no no no no no Renin secretion Non-alcoholic fatty liver disease 0 0.764822134 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Non-alcoholic fatty liver disease 0 -0.567193676 -0.423166023 kegg kegg NA NA no no no no no no Retinol metabolism Non-alcoholic fatty liver disease -0.520869565 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Non-alcoholic fatty liver disease 0.793043478 0.868577075 0.616988417 kegg kegg NA NA no no up no no no Ribosome Non-alcoholic fatty liver disease 0.71826087 0.812252964 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Non-alcoholic fatty liver disease 0 -0.571146245 0 kegg kegg NA NA no no no no no no RNA degradation Non-alcoholic fatty liver disease 0.710434783 0.592885375 0 kegg kegg NA NA no no no no no no RNA polymerase Non-alcoholic fatty liver disease 0 0.469367589 0 kegg kegg NA NA no no no no no no RNA transport Non-alcoholic fatty liver disease 0 0.468379447 0 kegg kegg NA NA no no no no no no Ruminococcus Non-alcoholic fatty liver disease 0 0.425459452 0 Genus kegg 0.0679 NA no no dn no no no Signaling pathways regulating pluripotency of stem cells Non-alcoholic fatty liver disease 0.662608696 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Non-alcoholic fatty liver disease 0 -0.604743083 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Non-alcoholic fatty liver disease 0.505217391 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Non-alcoholic fatty liver disease -0.497391304 -0.793478261 0 kegg kegg NA NA no no no no no no Sulfur metabolism Non-alcoholic fatty liver disease -0.445217391 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Non-alcoholic fatty liver disease 0 -0.554347826 0 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Non-alcoholic fatty liver disease 0 -0.460474308 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Non-alcoholic fatty liver disease 0.688695652 0.572134387 0 kegg kegg NA NA no no no no no no Thermogenesis Non-alcoholic fatty liver disease 0.944347826 0.929841897 0.848133848 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Non-alcoholic fatty liver disease 0 0.56916996 0.518661519 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Non-alcoholic fatty liver disease 0 0.653162055 0 kegg kegg NA NA no no no no no no Tight junction Non-alcoholic fatty liver disease 0 0.459486166 0 kegg kegg NA NA no no no no no no TNF signaling pathway Non-alcoholic fatty liver disease 0 -0.436758893 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Non-alcoholic fatty liver disease 0 -0.538537549 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Non-alcoholic fatty liver disease -0.619130435 0 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Non-alcoholic fatty liver disease 0 -0.566205534 -0.441441441 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Non-alcoholic fatty liver disease -0.452173913 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Non-alcoholic fatty liver disease 0.56173913 0.813241107 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Non-alcoholic fatty liver disease -0.526956522 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Non-alcoholic fatty liver disease 0.723478261 0.824110672 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Non-alcoholic fatty liver disease 0.722608696 0.550395257 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Non-homologous end-joining 0.808695652 0.481225296 0.464864865 kegg kegg NA NA no no no no no no ABC transporters Non-homologous end-joining 0.427826087 0 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Non-homologous end-joining 0.619130435 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Non-homologous end-joining 0.682608696 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Non-homologous end-joining 0.753043478 0.453557312 0 kegg kegg NA NA no no no no no no Base excision repair Non-homologous end-joining 0 0 0.516087516 kegg kegg NA NA no no no no no no beta-Alanine metabolism Non-homologous end-joining 0.854782609 0.808300395 0.721750322 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Non-homologous end-joining 0.623478261 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Non-homologous end-joining 0.451304348 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Non-homologous end-joining 0.79826087 0.78458498 0.588931789 kegg kegg NA NA no no no no no no Butanoate metabolism Non-homologous end-joining 0.884347826 0.807312253 0.762676963 kegg kegg NA NA no no no no no no Carbon metabolism Non-homologous end-joining 0.812173913 0.699604743 0.417760618 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Non-homologous end-joining 0.828695652 0.804347826 0.622136422 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Non-homologous end-joining 0.600869565 0.834980237 0.587387387 kegg kegg NA NA no no no no no no DNA replication Non-homologous end-joining 0.602608696 0.621541502 0.457142857 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Non-homologous end-joining 0.424347826 0.686758893 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Non-homologous end-joining 0.755652174 0.65513834 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Non-homologous end-joining 0 0.420948617 0.440669241 kegg kegg NA NA no no no no no no Ether lipid metabolism Non-homologous end-joining -0.524347826 0 0 kegg kegg NA NA no no no no no no Fatty acid degradation Non-homologous end-joining 0.546956522 0 0.42985843 kegg kegg NA NA no no no no no no Fatty acid elongation Non-homologous end-joining 0.788695652 0.896245059 0.726640927 kegg kegg NA NA no no no no no no Fatty acid metabolism Non-homologous end-joining 0.59826087 0 0.414157014 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Non-homologous end-joining 0.626956522 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Non-homologous end-joining 0.613913043 0 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Non-homologous end-joining 0.866956522 0.835968379 0.631917632 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Non-homologous end-joining 0 -0.65513834 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Non-homologous end-joining 0.60173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Non-homologous end-joining -0.493913043 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Non-homologous end-joining -0.62173913 -0.557312253 0 kegg kegg NA NA no no no no no no Histidine metabolism Non-homologous end-joining 0.508695652 0 0 kegg kegg NA NA no no no no no no Homologous recombination Non-homologous end-joining 0.469565217 0 0.431145431 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Non-homologous end-joining -0.540869565 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Non-homologous end-joining 0.526086957 0.731225296 0 kegg kegg NA NA no no no no no no Mismatch repair Non-homologous end-joining 0.717391304 0.765810277 0.644272844 kegg kegg NA NA no no no no no no mRNA surveillance pathway Non-homologous end-joining -0.577391304 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Non-homologous end-joining 0.537391304 0 0.413899614 kegg kegg NA NA no no no no no no Nucleotide excision repair Non-homologous end-joining 0.615652174 0.596837945 0.546460746 kegg kegg NA NA no no no no no no One carbon pool by folate Non-homologous end-joining 0.562608696 0.501976285 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Non-homologous end-joining -0.593043478 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Non-homologous end-joining 0.639130435 0.600790514 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Non-homologous end-joining 0.697391304 0.721343874 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Non-homologous end-joining 0.785217391 0.889328063 0.519176319 kegg kegg NA NA no no no no no no Propanoate metabolism Non-homologous end-joining 0.694782609 0.850790514 0.661003861 kegg kegg NA NA no no no no no no Proteasome Non-homologous end-joining 0 0.647233202 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Non-homologous end-joining 0.732173913 0.480237154 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Non-homologous end-joining 0.695652174 0.750988142 0.71016731 kegg kegg NA NA no no no no no no Retinol metabolism Non-homologous end-joining 0.771304348 0.644268775 0.497812098 kegg kegg NA NA no no no no no no Ribosome Non-homologous end-joining -0.486956522 0 0 kegg kegg NA NA no no no no no no RNA degradation Non-homologous end-joining -0.523478261 0 0 kegg kegg NA NA no no no no no no RNA transport Non-homologous end-joining 0.42 0.502964427 0.541570142 kegg kegg NA NA no no no no no no Steroid biosynthesis Non-homologous end-joining 0 0.708498024 0.43011583 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Non-homologous end-joining 0.573913043 0.721343874 0 kegg kegg NA NA no no no no no no Sulfur metabolism Non-homologous end-joining 0.44173913 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Non-homologous end-joining 0.642608696 0.645256917 0.583268983 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Non-homologous end-joining 0 -0.62944664 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Non-homologous end-joining 0 0.425889328 0 kegg kegg NA NA no no no no no no Thiamine metabolism Non-homologous end-joining 0.457391304 0.656126482 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Non-homologous end-joining 0.85826087 0.866600791 0.719433719 kegg kegg NA NA no up no no no no Tyrosine metabolism Non-homologous end-joining 0.779130435 0.777667984 0.757528958 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Non-homologous end-joining 0.689565217 0.690711462 0.501930502 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Non-homologous end-joining 0.810434783 0.714426877 0.686486486 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Non-small cell lung cancer -0.439130435 0 0 kegg kegg NA NA no no no no no no ABC transporters Non-small cell lung cancer 0 0.698616601 0.426512227 kegg kegg NA NA no up up no no no Acute myeloid leukemia Non-small cell lung cancer 0.590434783 0.627470356 0.501158301 kegg kegg NA NA no no no no no no Adherens junction Non-small cell lung cancer -0.420869565 -0.545454545 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Non-small cell lung cancer 0 0.447628458 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Non-small cell lung cancer 0.54 0.494071146 0.448133848 kegg kegg NA NA no no no no no no Alcoholism Non-small cell lung cancer 0 0 -0.461003861 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Non-small cell lung cancer 0.731304348 0.509881423 0.591248391 kegg kegg NA NA no no no no no no Alzheimer disease Non-small cell lung cancer 0 -0.423913043 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Non-small cell lung cancer -0.591304348 0 0 kegg kegg NA NA no no no no no no Amoebiasis Non-small cell lung cancer 0 0.424901186 0 kegg kegg NA NA no no no no no no Anaerostipes Non-small cell lung cancer 0 0 -0.401243218 butyrate-producing Genus kegg 0.568 NA no no no no no no Antigen processing and presentation Non-small cell lung cancer 0 -0.513833992 -0.515572716 kegg kegg NA NA no no no no no no Apelin signaling pathway Non-small cell lung cancer 0 -0.56027668 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Non-small cell lung cancer 0 0.538537549 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Non-small cell lung cancer -0.693913043 0 -0.633462033 kegg kegg NA NA no no no no no no Autophagy - animal Non-small cell lung cancer 0.626956522 0.66798419 0.551351351 kegg kegg NA NA no no no no no no Autophagy - other Non-small cell lung cancer 0.532173913 0.578063241 0.609009009 kegg kegg NA NA no no no no no no Axon guidance Non-small cell lung cancer 0.444347826 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Non-small cell lung cancer 0.49826087 0.450592885 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Non-small cell lung cancer -0.495652174 -0.62055336 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Non-small cell lung cancer 0.513043478 0.513833992 0.685714286 kegg kegg NA NA no no no no no no Basal transcription factors Non-small cell lung cancer 0 0 0.411068211 kegg kegg NA NA no no no no no no beta-Alanine metabolism Non-small cell lung cancer -0.543478261 -0.674901186 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Non-small cell lung cancer 0 0 -0.543629344 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Non-small cell lung cancer -0.579130435 0 -0.426769627 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Non-small cell lung cancer -0.513913043 -0.622529644 0 kegg kegg NA NA no no no no no no Bladder cancer Non-small cell lung cancer 0 0.516798419 0 kegg kegg NA NA no no no no no no Butanoate metabolism Non-small cell lung cancer -0.506956522 -0.57312253 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Non-small cell lung cancer 0.65826087 0.469367589 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Non-small cell lung cancer 0.468695652 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Non-small cell lung cancer 0.86173913 0.867588933 0.781467181 kegg kegg NA NA no no no no no no Carbon metabolism Non-small cell lung cancer -0.547826087 -0.586956522 -0.442213642 kegg kegg NA NA no no no no no no Cell cycle Non-small cell lung cancer 0 0 0.502445302 kegg kegg NA NA no no no no no no Chagas disease Non-small cell lung cancer 0.665217391 0.618577075 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Non-small cell lung cancer -0.62173913 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Non-small cell lung cancer 0 0.514822134 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Non-small cell lung cancer 0.451304348 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Non-small cell lung cancer 0.550434783 0 0.665379665 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Non-small cell lung cancer 0.809565217 0.695652174 0.434234234 kegg kegg NA NA no no no no no no Circadian entrainment Non-small cell lung cancer 0 -0.489130435 -0.433719434 kegg kegg NA NA no up up no no no Circadian rhythm Non-small cell lung cancer 0.536521739 0 0.64041184 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Non-small cell lung cancer -0.535652174 -0.64229249 0 kegg kegg NA NA no no no no no no Clostridium Non-small cell lung cancer 0 -0.609245673 0 Genus kegg 0.925 NA no no no no no no Collecting duct acid secretion Non-small cell lung cancer -0.454782609 -0.553359684 -0.504247104 kegg kegg NA NA no no no no no no Colorectal cancer Non-small cell lung cancer 0.693913043 0.502964427 0.816216216 kegg kegg NA NA no no no no no no Complement and coagulation cascades Non-small cell lung cancer 0 0 -0.443758044 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Non-small cell lung cancer 0 -0.524703557 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Non-small cell lung cancer -0.413043478 -0.650197628 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Non-small cell lung cancer -0.586956522 -0.581027668 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Non-small cell lung cancer -0.699130435 -0.66798419 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Non-small cell lung cancer 0 -0.415019763 0 kegg kegg NA NA no no no no no no Endocrine resistance Non-small cell lung cancer 0.405217391 0 0 kegg kegg NA NA no no no no no no Endometrial cancer Non-small cell lung cancer 0.88 0.793478261 0.765508366 kegg kegg NA NA no no no no no no ErbB signaling pathway Non-small cell lung cancer 0.932173913 0.924901186 0.844272844 kegg kegg NA NA no no no no no no Estrogen signaling pathway Non-small cell lung cancer 0 -0.43083004 0 kegg kegg NA NA no no no no no no Fatty acid elongation Non-small cell lung cancer -0.615652174 -0.703557312 -0.409266409 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Non-small cell lung cancer 0.693043478 0.538537549 0.475675676 kegg kegg NA NA no no no no no no Ferroptosis Non-small cell lung cancer 0 0 -0.531788932 kegg kegg NA NA no no no no no no Focal adhesion Non-small cell lung cancer 0 -0.651185771 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Non-small cell lung cancer 0.486086957 0.672924901 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Non-small cell lung cancer 0 0.592885375 0 kegg kegg NA NA no no no no no no Galactose metabolism Non-small cell lung cancer 0 0.448616601 0 kegg kegg NA NA no no no no no no Gastric acid secretion Non-small cell lung cancer -0.460869565 -0.533596838 0 kegg kegg NA NA no no no no no no Glioma Non-small cell lung cancer 0.580869565 0 0.632175032 kegg kegg NA NA no no no no no no Glutamatergic synapse Non-small cell lung cancer 0 0.504940711 0 kegg kegg NA NA no up up no no no Glutathione metabolism Non-small cell lung cancer -0.547826087 -0.462450593 -0.671299871 kegg kegg NA NA no no no no no no Glycerolipid metabolism Non-small cell lung cancer 0 0.743083004 0.675933076 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Non-small cell lung cancer 0.410434783 0.585968379 0.705534106 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Non-small cell lung cancer -0.470434783 0 -0.406692407 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Non-small cell lung cancer -0.574782609 -0.785573123 -0.424710425 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Non-small cell lung cancer 0 0.804347826 0.553925354 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Non-small cell lung cancer -0.413043478 0 0.52998713 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Non-small cell lung cancer 0.411304348 0 0.548005148 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Non-small cell lung cancer 0 0 0.433976834 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - globo and isoglobo series Non-small cell lung cancer -0.510434783 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Non-small cell lung cancer 0.464347826 0.502964427 0.491119691 kegg kegg NA NA no no no no no no GnRH secretion Non-small cell lung cancer 0.937391304 0.960474308 0.932046332 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Non-small cell lung cancer 0.666956522 0.760869565 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Non-small cell lung cancer 0.508695652 0 0.767310167 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Non-small cell lung cancer 0 -0.590909091 0 kegg kegg NA NA no no no no no no Hepatitis B Non-small cell lung cancer 0.748695652 0.633399209 0.54980695 kegg kegg NA NA no no no no no no Hepatitis C Non-small cell lung cancer 0.509565217 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Non-small cell lung cancer 0 -0.548418972 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Non-small cell lung cancer 0 -0.482213439 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Non-small cell lung cancer 0 0 0.577606178 kegg kegg NA NA no no no no no no Histidine metabolism Non-small cell lung cancer -0.423478261 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Non-small cell lung cancer 0 0.42687747 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Non-small cell lung cancer 0 0 -0.404633205 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Non-small cell lung cancer 0 0.646245059 0.724324324 kegg kegg NA NA no no no no no no Insulin resistance Non-small cell lung cancer 0.733913043 0.781620553 0.572200772 kegg kegg NA NA no no no no no no Insulin signaling pathway Non-small cell lung cancer 0 -0.53458498 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Non-small cell lung cancer 0 0.773715415 0 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Non-small cell lung cancer 0 0 -0.485714286 kegg kegg NA NA no no dn no no no Lachnospira Non-small cell lung cancer 0 -0.529280965 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Legionellosis Non-small cell lung cancer 0 0 -0.529472329 kegg kegg NA NA no no no no no no Leishmaniasis Non-small cell lung cancer 0 -0.457509881 -0.587387387 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Non-small cell lung cancer 0 -0.479249012 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Non-small cell lung cancer -0.485217391 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Non-small cell lung cancer 0 -0.59486166 0.435521236 kegg kegg NA NA no no up no no no Longevity regulating pathway Non-small cell lung cancer 0.450434783 0 0 kegg kegg NA NA no no no no no no Lysine degradation Non-small cell lung cancer 0.472173913 0.539525692 0.684684685 kegg kegg NA NA no no no no no no Malaria Non-small cell lung cancer 0 0 -0.515830116 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Non-small cell lung cancer 0.622608696 0.558300395 0.670785071 kegg kegg NA NA no no no no no no MAPK signaling pathway Non-small cell lung cancer 0 0 0.682882883 kegg kegg NA NA no no no no no no Melanoma Non-small cell lung cancer 0.765217391 0.755928854 0.741312741 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Non-small cell lung cancer -0.648695652 -0.646245059 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Non-small cell lung cancer 0.451304348 0.71541502 0.760875161 kegg kegg NA NA no no no no no no Mineral absorption Non-small cell lung cancer 0 0 -0.503989704 kegg kegg NA NA no no no no no no Mismatch repair Non-small cell lung cancer -0.47826087 -0.459486166 0 kegg kegg NA NA no no no no no no Mitophagy - animal Non-small cell lung cancer 0 0 -0.462033462 kegg kegg NA NA no no no no no no mRNA surveillance pathway Non-small cell lung cancer 0.479130435 0 0.591248391 kegg kegg NA NA no no no no no no mTOR signaling pathway Non-small cell lung cancer 0 -0.448616601 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Non-small cell lung cancer 0 0 0.434491634 kegg kegg NA NA no no no no no no Necroptosis Non-small cell lung cancer 0 0 -0.521750322 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Non-small cell lung cancer 0.68 0.501976285 0.411840412 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Non-small cell lung cancer 0 0 -0.428828829 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Non-small cell lung cancer 0.616521739 0.670948617 0 kegg kegg NA NA no no no no no no Nicotine addiction Non-small cell lung cancer 0 0.668972332 0 kegg kegg NA NA no up up no no no Non-homologous end-joining Non-small cell lung cancer -0.523478261 -0.679841897 0 kegg kegg NA NA no no no no no no Notch signaling pathway Non-small cell lung cancer 0.493913043 0.732213439 0.703732304 kegg kegg NA NA no no no no no no Oocyte meiosis Non-small cell lung cancer 0 -0.671936759 0 kegg kegg NA NA no no no no no no Other glycan degradation Non-small cell lung cancer 0 0.601778656 0.570913771 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Non-small cell lung cancer 0.406086957 0.544466403 0.662548263 kegg kegg NA NA no no no no no no Oxidative phosphorylation Non-small cell lung cancer 0 -0.422924901 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Non-small cell lung cancer -0.476521739 -0.494071146 -0.502445302 kegg kegg NA NA no no no no no no p53 signaling pathway Non-small cell lung cancer 0.473043478 0.538537549 0 kegg kegg NA NA no no no no no no Pancreatic cancer Non-small cell lung cancer 0.557391304 0.526679842 0.51042471 kegg kegg NA NA no no no no no no Pathways in cancer Non-small cell lung cancer 0.647826087 0.764822134 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Non-small cell lung cancer -0.671304348 -0.501976285 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Non-small cell lung cancer -0.55826087 -0.522727273 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Non-small cell lung cancer 0.491304348 0 0.75984556 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Non-small cell lung cancer 0.566956522 0.733201581 0 kegg kegg NA NA no up up no no no Phototransduction Non-small cell lung cancer 0 -0.894268775 0 kegg kegg NA NA no no no no no no Platelet activation Non-small cell lung cancer -0.482608696 -0.523715415 0 kegg kegg NA NA no no no no no no Platinum drug resistance Non-small cell lung cancer 0.44173913 0.571146245 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Non-small cell lung cancer -0.446956522 0 -0.455083655 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Non-small cell lung cancer -0.563478261 -0.777667984 -0.404890605 kegg kegg NA NA no no no no no no Prion disease Non-small cell lung cancer 0 -0.505928854 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Non-small cell lung cancer 0.564347826 0.618577075 0.796911197 kegg kegg NA NA no no no no no no Prolactin signaling pathway Non-small cell lung cancer 0.684347826 0.559288538 0.522779923 kegg kegg NA NA no no no no no no Propanoate metabolism Non-small cell lung cancer -0.439130435 -0.688735178 0 kegg kegg NA NA no no no no no no Prostate cancer Non-small cell lung cancer 0.78173913 0.65513834 0.438095238 kegg kegg NA NA no no no no no no Proteasome Non-small cell lung cancer 0 -0.747035573 0 kegg kegg NA NA no no no no no no Protein export Non-small cell lung cancer 0 -0.555335968 0.402059202 kegg kegg NA NA no no no no no no Pyrimidine metabolism Non-small cell lung cancer -0.525217391 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Non-small cell lung cancer -0.437391304 -0.653162055 0 kegg kegg NA NA no no no no no no Ras signaling pathway Non-small cell lung cancer 0 0 0.552638353 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Non-small cell lung cancer -0.625217391 -0.81916996 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Non-small cell lung cancer 0.523478261 0.57312253 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Non-small cell lung cancer 0.504347826 0 0 kegg kegg NA NA no no no no no no Renin secretion Non-small cell lung cancer -0.425217391 -0.470355731 0 kegg kegg NA NA no no no no no no Retinol metabolism Non-small cell lung cancer -0.499130435 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Non-small cell lung cancer 0 -0.507905138 0 kegg kegg NA NA no no up no no no Ribosome Non-small cell lung cancer 0 -0.511857708 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Non-small cell lung cancer 0 0 0.41981982 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Non-small cell lung cancer 0.587826087 0.609683794 0 kegg kegg NA NA no no no no no no RNA degradation Non-small cell lung cancer 0.44173913 0 0.537194337 kegg kegg NA NA no no no no no no RNA transport Non-small cell lung cancer 0 -0.422924901 0 kegg kegg NA NA no no no no no no Roseburia Non-small cell lung cancer -0.406086957 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Ruminococcus Non-small cell lung cancer 0 -0.47548437 0 Genus kegg 0.0679 NA no no dn no no no Salivary secretion Non-small cell lung cancer 0 0 -0.427284427 kegg kegg NA NA no no no no no no Selenocompound metabolism Non-small cell lung cancer 0 0 0.473359073 kegg kegg NA NA no no no no no no Shigellosis Non-small cell lung cancer 0 0 -0.58018018 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Non-small cell lung cancer 0.808695652 0.726284585 0.848133848 kegg kegg NA NA no no no no no no Small cell lung cancer Non-small cell lung cancer 0.677391304 0.699604743 0 kegg kegg NA NA no no up no no no SNARE interactions in vesicular transport Non-small cell lung cancer 0 0.575098814 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Non-small cell lung cancer 0.62173913 0 0.668211068 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Non-small cell lung cancer 0.567826087 0 0.543886744 kegg kegg NA NA no no no no no no Spliceosome Non-small cell lung cancer 0 0.562252964 0.448648649 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Non-small cell lung cancer 0 0 -0.485456885 kegg kegg NA NA up no no no no no Steroid biosynthesis Non-small cell lung cancer 0 -0.589920949 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Non-small cell lung cancer -0.752173913 -0.539525692 0 kegg kegg NA NA no no no no no no Sulfur metabolism Non-small cell lung cancer -0.635652174 -0.488142292 -0.559073359 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Non-small cell lung cancer 0.493043478 0.542490119 0.416473616 kegg kegg NA NA no no no no no no Taste transduction Non-small cell lung cancer 0 0 0.708880309 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Non-small cell lung cancer 0.520869565 0.835968379 0.585585586 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Non-small cell lung cancer 0 -0.589920949 0.45971686 kegg kegg NA NA no no no no no no Thermogenesis Non-small cell lung cancer 0 -0.424901186 0 kegg kegg NA NA no no no no no no Thiamine metabolism Non-small cell lung cancer 0 -0.616600791 0 kegg kegg NA NA no no no no no no Thyroid cancer Non-small cell lung cancer 0 -0.46541502 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Non-small cell lung cancer 0 0 -0.44967825 kegg kegg NA NA no no no no no no Tight junction Non-small cell lung cancer -0.633043478 -0.700592885 -0.580694981 kegg kegg NA NA no no no no no no TNF signaling pathway Non-small cell lung cancer 0.76 0.684782609 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Non-small cell lung cancer 0.673913043 0.43083004 0 yes kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Non-small cell lung cancer 0.520869565 0.658102767 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Non-small cell lung cancer -0.571304348 -0.691699605 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Non-small cell lung cancer 0.82 0.822134387 0.673101673 kegg kegg NA NA no no no no no no Tyrosine metabolism Non-small cell lung cancer -0.648695652 -0.565217391 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Non-small cell lung cancer -0.576521739 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Non-small cell lung cancer 0 0 -0.461261261 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Non-small cell lung cancer -0.49826087 -0.494071146 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Non-small cell lung cancer 0 0 0.417760618 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Non-small cell lung cancer 0 -0.502964427 -0.402316602 kegg kegg NA NA no no no no no no VEGF signaling pathway Non-small cell lung cancer 0.786956522 0.725296443 0.755984556 kegg kegg NA NA no no no no no no Vibrio cholerae infection Non-small cell lung cancer -0.42173913 -0.497035573 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Non-small cell lung cancer 0 0 -0.508365508 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Non-small cell lung cancer 0 0 0.531788932 kegg kegg NA NA no no no no no no Wnt signaling pathway Non-small cell lung cancer 0 0 0.661776062 kegg kegg NA NA no no no no no no 14:0/18:0-PC+blood nonanoic acid C9+blood 0 0 -0.424957265 serum_phospholipids serum_mcfa 0.00289 6.51E-11 up up no dn dn no 16:0/16:1-PC+blood nonanoic acid C9+blood 0 0 -0.463247863 serum_phospholipids serum_mcfa 0.00283 6.51E-11 up up no dn dn no 16:0/16:1-PI+blood nonanoic acid C9+blood 0 0 -0.471452991 serum_phospholipids serum_mcfa 0.262 6.51E-11 no no no dn dn no 16:0/18:2-PI+blood nonanoic acid C9+blood 0 0 -0.43042735 serum_phospholipids serum_mcfa 0.269 6.51E-11 no no no dn dn no 16:0/18:3-PC+blood nonanoic acid C9+blood 0 0 -0.44957265 serum_phospholipids serum_mcfa 0.00216 6.51E-11 no up up dn dn no 16:0/20:3-PC+blood nonanoic acid C9+blood 0 0.634803922 0 serum_phospholipids serum_mcfa 5.43E-06 6.51E-11 no up up dn dn no 16:1/18:2-PG+blood nonanoic acid C9+blood 0 0 0.442051282 serum_phospholipids serum_mcfa 1.40E-08 6.51E-11 no up up dn dn no 18:0/20:3-PC+blood nonanoic acid C9+blood 0 0 -0.490598291 serum_phospholipids serum_mcfa 0.0682 6.51E-11 no up no dn dn no 18:0/22:6-PC+blood nonanoic acid C9+blood 0 -0.512254902 0 serum_phospholipids serum_mcfa 0.0775 6.51E-11 no no up dn dn no 18:0/22:6-PE+blood nonanoic acid C9+blood 0 -0.5 0 serum_phospholipids serum_mcfa 0.00022 6.51E-11 up up no dn dn no 18:1/18:1-PC+blood nonanoic acid C9+blood 0 0.671568627 0 serum_phospholipids serum_mcfa 1.34E-05 6.51E-11 no up up dn dn no 18:1/20:3-PC+blood nonanoic acid C9+blood 0 0.659313725 -0.44 serum_phospholipids serum_mcfa 0.00872 6.51E-11 no up up dn dn no 18:1/20:4-PI+blood nonanoic acid C9+blood 0 0 -0.581538462 serum_phospholipids serum_mcfa 0.192 6.51E-11 no no no dn dn no 18:2-LPE+blood nonanoic acid C9+blood 0 0.610294118 0 serum_phospholipids serum_mcfa 0.112 6.51E-11 no no no dn dn no 18:3/16:0-PE+blood nonanoic acid C9+blood -0.473684211 0 0 serum_phospholipids serum_mcfa 0.00149 6.51E-11 up up no dn dn no 18:3n6+blood nonanoic acid C9+blood 0 0 -0.465982906 serum_fattyacid serum_mcfa 0.0463 6.51E-11 up no dn dn dn no 2-methyl-butyric acid m-C4+blood nonanoic acid C9+blood 0.560902256 0 0 serum_scfa serum_mcfa 0.262 6.51E-11 no no no dn dn no 20:0/20:4-PE+blood nonanoic acid C9+blood -0.482706767 0 0 serum_phospholipids serum_mcfa 0.00128 6.51E-11 up up no dn dn no 20:2-LPE+blood nonanoic acid C9+blood -0.544360902 0 0 serum_phospholipids serum_mcfa 0.177 6.51E-11 no no no dn dn no 20:2/18:0-PC+blood nonanoic acid C9+blood 0 0 -0.474188034 serum_phospholipids serum_mcfa 0.0427 6.51E-11 no up no dn dn no 20:2+blood nonanoic acid C9+blood 0 0.632352941 0 serum_fattyacid serum_mcfa 0.478 6.51E-11 no no no dn dn no 20:3-LPE+blood nonanoic acid C9+blood 0 0.629901961 -0.416752137 serum_phospholipids serum_mcfa 0.084 6.51E-11 no up no dn dn no 20:3n6+blood nonanoic acid C9+blood 0 0.504901961 0 serum_fattyacid serum_mcfa 0.0884 6.51E-11 up no no dn dn no 20:5-LPC+blood nonanoic acid C9+blood 0 -0.713235294 0 serum_phospholipids serum_mcfa 0.558 6.51E-11 no no no dn dn no 22:2-LPA+blood nonanoic acid C9+blood 0 0 -0.407863248 serum_phospholipids serum_mcfa 0.0443 6.51E-11 dn no no dn dn no 22:6-LPC+blood nonanoic acid C9+blood 0 -0.654411765 0 serum_phospholipids serum_mcfa 0.127 6.51E-11 no no up dn dn no 22:6n3+blood nonanoic acid C9+blood 0 -0.5 0 serum_fattyacid serum_mcfa 0.792 6.51E-11 no no no dn dn no acetic acid C2+blood nonanoic acid C9+blood 0.47518797 0 0 serum_scfa serum_mcfa 0.000193 6.51E-11 up dn no dn dn no capric acid C6+blood nonanoic acid C9+blood 0 0 0.410598291 serum_scfa serum_mcfa 0.433 6.51E-11 no no no dn dn no Cysteine+blood nonanoic acid C9+blood 0 0.50245098 0 yes serum_aminoacids serum_mcfa 1.81E-07 6.51E-11 dn up up dn dn no d18:1-18:0-SM+blood nonanoic acid C9+blood 0 -0.539215686 0 serum_phospholipids serum_mcfa 0.97 6.51E-11 no no no dn dn no d18:1-20:0-SM+blood nonanoic acid C9+blood -0.455639098 0 0 serum_phospholipids serum_mcfa 0.933 6.51E-11 no no no dn dn no decanoic acid C10+blood nonanoic acid C9+blood 0.843609023 0.757352941 0.474188034 serum_mcfa serum_mcfa 6.64E-11 6.51E-11 dn dn no dn dn no HDCA+blood nonanoic acid C9+blood 0 0 0.410882541 serum_bileacids serum_mcfa 0.483 6.51E-11 no no no dn dn no heptanoic acid C7+blood nonanoic acid C9+blood 0.932330827 0.727941176 0.461196581 serum_mcfa serum_mcfa 8.27E-11 6.51E-11 dn dn no dn dn no iso-heptanoic acid C7+blood nonanoic acid C9+blood 0.485714286 0 0 serum_mcfa serum_mcfa 0.00256 6.51E-11 up up no dn dn no isobutyric acid C4+blood nonanoic acid C9+blood 0.509774436 0 0 serum_scfa serum_mcfa 0.0151 6.51E-11 up up no dn dn no L-Alanine+blood nonanoic acid C9+blood 0 0 -0.565128205 yes serum_aminoacids serum_mcfa 0.00138 6.51E-11 up up no dn dn no L-Asparagine+blood nonanoic acid C9+blood 0.517293233 0 0 serum_aminoacids serum_mcfa 0.784 6.51E-11 no no no dn dn no lauric acid C12+blood nonanoic acid C9+blood 0.581954887 0.919117647 0.742222222 serum_mcfa serum_mcfa 0.015 6.51E-11 no dn dn dn dn no n3+blood nonanoic acid C9+blood 0 -0.536764706 0 serum_fattyacid serum_mcfa 0.806 6.51E-11 no no no dn dn no n6/n3+blood nonanoic acid C9+blood 0 0.659313725 0 serum_fattyacid serum_mcfa 0.226 6.51E-11 no no no dn dn no 2-Oxocarboxylic acid metabolism Notch signaling pathway -0.550434783 0 0 kegg kegg NA NA no no no no no no ABC transporters Notch signaling pathway 0 0.48715415 0.593050193 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" Notch signaling pathway 0 0 -0.408494208 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Notch signaling pathway -0.455652174 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Notch signaling pathway -0.603478261 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Notch signaling pathway -0.54 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Notch signaling pathway 0 0 -0.632175032 kegg kegg NA NA no no no no no no Antifolate resistance Notch signaling pathway 0 0 0.636808237 kegg kegg NA NA no no no no no no Apoptosis - multiple species Notch signaling pathway 0 0.440711462 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Notch signaling pathway 0 0 -0.432689833 kegg kegg NA NA no no no no no no Arginine biosynthesis Notch signaling pathway 0 0 -0.499356499 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Notch signaling pathway 0 0 0.572458172 kegg kegg NA NA no no no no no no Autophagy - animal Notch signaling pathway 0 0.566205534 0 kegg kegg NA NA no no no no no no Autophagy - other Notch signaling pathway 0 0 0.516344916 kegg kegg NA NA no no no no no no Basal transcription factors Notch signaling pathway 0 0 0.51016731 kegg kegg NA NA no no no no no no beta-Alanine metabolism Notch signaling pathway -0.497391304 -0.458498024 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Notch signaling pathway -0.475652174 0 -0.524581725 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Notch signaling pathway -0.522608696 0 -0.457657658 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Notch signaling pathway -0.473913043 -0.532608696 0 kegg kegg NA NA no no no no no no Butanoate metabolism Notch signaling pathway -0.505217391 -0.475296443 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Notch signaling pathway 0.42 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Notch signaling pathway -0.613913043 -0.511857708 0 kegg kegg NA NA no no no no no no Cell cycle Notch signaling pathway 0 0 0.518404118 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Notch signaling pathway 0.567826087 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Notch signaling pathway -0.486956522 -0.488142292 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Notch signaling pathway -0.586086957 -0.574110672 0 kegg kegg NA NA no no no no no no DNA replication Notch signaling pathway 0 0 0.44015444 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Notch signaling pathway -0.712173913 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Notch signaling pathway -0.559130435 -0.502964427 0.433719434 kegg kegg NA NA no no no no no no Endocrine resistance Notch signaling pathway 0 0.518774704 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Notch signaling pathway 0.556521739 0.670948617 0.58970399 kegg kegg NA NA no no no no no no Ether lipid metabolism Notch signaling pathway 0.425217391 0 0.506563707 kegg kegg NA NA no no no no no no Fanconi anemia pathway Notch signaling pathway 0 0 0.447361647 kegg kegg NA NA no no no no no no Fatty acid elongation Notch signaling pathway 0 -0.592885375 0 kegg kegg NA NA no no no no no no Ferroptosis Notch signaling pathway 0 0 -0.545945946 kegg kegg NA NA no no no no no no Folate biosynthesis Notch signaling pathway 0 0 0.553410553 kegg kegg NA NA no no no no no no FoxO signaling pathway Notch signaling pathway 0 0.473320158 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Notch signaling pathway -0.509565217 0.556324111 0 kegg kegg NA NA no no no no no no Galactose metabolism Notch signaling pathway 0 0 0.458429858 kegg kegg NA NA no no no no no no Glutathione metabolism Notch signaling pathway 0 0 -0.558301158 kegg kegg NA NA no no no no no no Glycerolipid metabolism Notch signaling pathway 0 0.596837945 0.78970399 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Notch signaling pathway 0.527826087 0.588932806 0.802316602 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Notch signaling pathway -0.439130435 0 -0.493693694 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Notch signaling pathway -0.811304348 -0.669960474 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Notch signaling pathway 0 0.692687747 0.466151866 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Notch signaling pathway 0 0 0.701930502 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Notch signaling pathway 0.546956522 0 0.477477477 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Notch signaling pathway 0 0 0.614414414 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Notch signaling pathway 0.786956522 0.444664032 0.445559846 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Notch signaling pathway 0 0 -0.438610039 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Notch signaling pathway 0 -0.46541502 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Notch signaling pathway 0 0.613636364 0.712226512 kegg kegg NA NA no no no no no no Linoleic acid metabolism Notch signaling pathway -0.470434783 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Notch signaling pathway 0.412173913 0 -0.484169884 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Notch signaling pathway 0 -0.499011858 0 kegg kegg NA NA no no no no no no Lysine degradation Notch signaling pathway 0 0.5 0.764993565 kegg kegg NA NA no no no no no no Lysosome Notch signaling pathway 0.433043478 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Notch signaling pathway 0.572173913 0.503952569 0.768854569 kegg kegg NA NA no no no no no no MAPK signaling pathway Notch signaling pathway 0 0 0.562676963 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Notch signaling pathway -0.690434783 -0.451581028 0 kegg kegg NA NA no no no no no no Mismatch repair Notch signaling pathway -0.423478261 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Notch signaling pathway 0 0 -0.53976834 kegg kegg NA NA no no no no no no mRNA surveillance pathway Notch signaling pathway 0.533913043 0 0.605148005 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Notch signaling pathway -0.537391304 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Notch signaling pathway 0 0 0.433204633 kegg kegg NA NA no no no no no no Necroptosis Notch signaling pathway 0 0 -0.587644788 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Notch signaling pathway 0 0.561264822 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Notch signaling pathway 0 0 -0.492664093 kegg kegg NA NA no no no no no no Non-homologous end-joining Notch signaling pathway -0.608695652 -0.557312253 0 kegg kegg NA NA no no no no no no One carbon pool by folate Notch signaling pathway 0 0 0.548005148 kegg kegg NA NA no no no no no no Oocyte meiosis Notch signaling pathway 0 -0.605731225 0 kegg kegg NA NA no no no no no no Other glycan degradation Notch signaling pathway 0 0.497035573 0.726640927 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Notch signaling pathway 0 0.491106719 0.726383526 kegg kegg NA NA no no no no no no p53 signaling pathway Notch signaling pathway 0 0.441699605 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Notch signaling pathway -0.59826087 0 0 kegg kegg NA NA no no no no no no Peroxisome Notch signaling pathway 0 0 -0.518918919 kegg kegg NA NA no no no no no no Phenylalanine metabolism Notch signaling pathway -0.47826087 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Notch signaling pathway 0.536521739 0 0.769369369 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Notch signaling pathway 0.484347826 0.630434783 0 kegg kegg NA NA no up up no no no Platinum drug resistance Notch signaling pathway 0 0.445652174 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Notch signaling pathway -0.470434783 0 -0.500900901 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Notch signaling pathway 0 -0.567193676 0 kegg kegg NA NA no no no no no no Propanoate metabolism Notch signaling pathway -0.637391304 -0.579051383 0 kegg kegg NA NA no no no no no no Proteasome Notch signaling pathway 0 -0.692687747 0 kegg kegg NA NA no no no no no no Protein export Notch signaling pathway 0 -0.468379447 0.410553411 kegg kegg NA NA no no no no no no Purine metabolism Notch signaling pathway 0 0 -0.441184041 kegg kegg NA NA no no no no no no Pyrimidine metabolism Notch signaling pathway 0 0 0.463577864 kegg kegg NA NA no no no no no no Pyruvate metabolism Notch signaling pathway -0.508695652 -0.524703557 0 kegg kegg NA NA no no no no no no Ras signaling pathway Notch signaling pathway 0 0 0.672586873 yes kegg kegg NA NA no up up no no no Retinol metabolism Notch signaling pathway -0.64 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Notch signaling pathway 0 0 0.561389961 kegg kegg NA NA no no no no no no RNA degradation Notch signaling pathway 0.52173913 0 0.648906049 kegg kegg NA NA no no no no no no RNA polymerase Notch signaling pathway 0 0 0.415701416 kegg kegg NA NA no no no no no no RNA transport Notch signaling pathway -0.503478261 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Notch signaling pathway 0 0 0.6 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Notch signaling pathway 0 0.440711462 0.416988417 kegg kegg NA NA no no no no no no Sphingolipid metabolism Notch signaling pathway 0 0 0.46048906 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Notch signaling pathway 0.54173913 0 0.547747748 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Notch signaling pathway -0.454782609 0 0.531016731 kegg kegg NA NA no no no no no no Sulfur metabolism Notch signaling pathway 0 0 -0.576319176 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Notch signaling pathway 0.414782609 0.731225296 0.531016731 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Notch signaling pathway 0 0 0.576576577 kegg kegg NA NA no no no no no no Thiamine metabolism Notch signaling pathway 0 -0.437747036 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Notch signaling pathway -0.417391304 -0.475296443 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Notch signaling pathway -0.590434783 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Notch signaling pathway 0 0 -0.52046332 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Notch signaling pathway -0.446086957 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Notch signaling pathway 0 0 0.425997426 kegg kegg NA NA no no no no no no Wnt signaling pathway Notch signaling pathway 0.568695652 0 0.8002574 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Nucleotide excision repair 0.442608696 0.664031621 0 kegg kegg NA NA no no no no no no ABC transporters Nucleotide excision repair 0.457391304 0 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" Nucleotide excision repair 0 -0.516798419 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Nucleotide excision repair 0 0.493083004 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Nucleotide excision repair 0.705217391 0.764822134 0.633719434 kegg kegg NA NA no no no no no no Antifolate resistance Nucleotide excision repair 0.459130435 0.658102767 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Nucleotide excision repair 0 -0.624505929 -0.472586873 kegg kegg NA NA no up no no no no Arginine biosynthesis Nucleotide excision repair 0 -0.564229249 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Nucleotide excision repair 0.457391304 0.450592885 0.563963964 kegg kegg NA NA no no no no no no Basal transcription factors Nucleotide excision repair 0.692173913 0.781620553 0.814157014 kegg kegg NA NA no no no no no no Base excision repair Nucleotide excision repair 0.809565217 0.803359684 0.891634492 kegg kegg NA NA no no no no no no beta-Alanine metabolism Nucleotide excision repair 0 0.479249012 0.454826255 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Nucleotide excision repair 0 -0.583003953 -0.480823681 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Nucleotide excision repair 0 0.732213439 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Nucleotide excision repair 0.704347826 0.559288538 0.546203346 kegg kegg NA NA no no no no no no Butanoate metabolism Nucleotide excision repair 0.60173913 0.787549407 0.742084942 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Nucleotide excision repair 0.757391304 0.801383399 0.659459459 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Nucleotide excision repair 0.771304348 0.745059289 0.783783784 kegg kegg NA NA no no no no no no DNA replication Nucleotide excision repair 0.977391304 0.931818182 0.877992278 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Nucleotide excision repair 0 0.766798419 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Nucleotide excision repair 0 0.58201581 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Nucleotide excision repair 0 0 0.54028314 kegg kegg NA NA no no no no no no Ether lipid metabolism Nucleotide excision repair 0 0.604743083 0.634234234 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Nucleotide excision repair 0 -0.554347826 0 kegg kegg NA NA no no no no no no Fatty acid elongation Nucleotide excision repair 0.434782609 0 0.539253539 kegg kegg NA NA no no no no no no Folate biosynthesis Nucleotide excision repair 0.445217391 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Nucleotide excision repair 0 0.48715415 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Nucleotide excision repair 0 0 0.465122265 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Nucleotide excision repair 0 0.489130435 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Nucleotide excision repair 0.407826087 0.425889328 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Nucleotide excision repair -0.569565217 -0.591897233 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Nucleotide excision repair 0 0.476284585 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Nucleotide excision repair -0.656521739 -0.445652174 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Nucleotide excision repair 0 0.709486166 0.41956242 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Nucleotide excision repair 0.544347826 0.511857708 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Nucleotide excision repair 0 -0.591897233 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Nucleotide excision repair 0 0 0.496525097 kegg kegg NA NA no no no no no no Linoleic acid metabolism Nucleotide excision repair 0 0.43083004 0 kegg kegg NA NA no no no no no no Lysine degradation Nucleotide excision repair 0 0 0.450965251 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Nucleotide excision repair 0 0.713438735 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Nucleotide excision repair 0 0.481225296 0.466666667 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Nucleotide excision repair 0.560869565 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Nucleotide excision repair 0.642608696 0.732213439 0.631660232 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Nucleotide excision repair 0 -0.650197628 -0.513770914 kegg kegg NA NA no no no no no no Nitrogen metabolism Nucleotide excision repair -0.5 -0.585968379 -0.491377091 kegg kegg NA NA no no no no no no One carbon pool by folate Nucleotide excision repair 0.911304348 0.931818182 0.735392535 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Nucleotide excision repair 0.430434783 0.437747036 0.573487773 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Nucleotide excision repair 0 -0.436758893 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Nucleotide excision repair 0.623478261 0.796442688 0.52998713 kegg kegg NA NA no no no no no no Pentose phosphate pathway Nucleotide excision repair -0.528695652 -0.666996047 -0.505534106 kegg kegg NA NA no no no no no no Phenylalanine metabolism Nucleotide excision repair 0 0.721343874 0 kegg kegg NA NA no no no no no no Platinum drug resistance Nucleotide excision repair 0.583478261 0 0.618275418 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Nucleotide excision repair 0 0.419960474 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Nucleotide excision repair 0 -0.704545455 -0.711454311 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Nucleotide excision repair 0.833043478 0.519762846 0 kegg kegg NA NA no no no no no no Propanoate metabolism Nucleotide excision repair 0.732173913 0.679841897 0.758815959 kegg kegg NA NA no no no no no no Proteasome Nucleotide excision repair 0 0.499011858 0 kegg kegg NA NA no no no no no no Protein export Nucleotide excision repair 0.559130435 0.513833992 0.44967825 kegg kegg NA NA no no no no no no Purine metabolism Nucleotide excision repair 0 0.494071146 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Nucleotide excision repair 0.489565217 0.84486166 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Nucleotide excision repair 0.843478261 0.743083004 0.738738739 kegg kegg NA NA no no no no no no Retinol metabolism Nucleotide excision repair 0.605217391 0.853754941 0.708365508 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Nucleotide excision repair 0.782608696 0.874505929 0.776061776 kegg kegg NA NA no no no no no no RNA degradation Nucleotide excision repair 0 0.581027668 0.491634492 kegg kegg NA NA no no no no no no RNA polymerase Nucleotide excision repair 0.64173913 0.837944664 0.794079794 kegg kegg NA NA no no no no no no RNA transport Nucleotide excision repair 0.576521739 0 0.441698842 kegg kegg NA NA no no no no no no Selenocompound metabolism Nucleotide excision repair 0.526086957 0.609683794 0.711711712 kegg kegg NA NA no no no no no no Sphingolipid metabolism Nucleotide excision repair -0.644347826 0 0 kegg kegg NA NA no no no no no no Spliceosome Nucleotide excision repair 0.650434783 0.414031621 0.604890605 kegg kegg NA NA no no no no no no Steroid biosynthesis Nucleotide excision repair 0.53826087 0.796442688 0.723552124 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Nucleotide excision repair 0.453913043 0.723320158 0.435778636 kegg kegg NA NA no no no no no no Sulfur metabolism Nucleotide excision repair 0 0.424901186 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Nucleotide excision repair 0.879130435 0.923913043 0.835521236 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Nucleotide excision repair 0.733913043 0.722332016 0.656885457 kegg kegg NA NA no no no no no no Thiamine metabolism Nucleotide excision repair 0.476521739 0.56916996 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Nucleotide excision repair 0.644347826 0.648221344 0.596911197 kegg kegg NA NA no up no no no no Tyrosine metabolism Nucleotide excision repair 0.59826087 0.839920949 0.66975547 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Nucleotide excision repair 0.720869565 0.904150198 0.827284427 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Nucleotide excision repair 0.813043478 0.839920949 0.805662806 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Nucleotide excision repair 0.491304348 0.649209486 0.567052767 kegg kegg NA NA no no no no no no 12-ketoDCA+blood nutriCA+blood 0.54517823 0 0 serum_bileacids serum_bileacids 0.517 0.726 no no no no no no 14:0-LPC+blood nutriCA+blood 0.603450592 0 0 serum_phospholipids serum_bileacids 0.00689 0.726 up up no no no no 14:0/16:0-PC+blood nutriCA+blood 0 0 -0.401398568 serum_phospholipids serum_bileacids 0.0358 0.726 no up no no no no 14:1/18:2-PG+blood nutriCA+blood 0.472879412 0 0 serum_phospholipids serum_bileacids 0.00259 0.726 no up up no no no 16:0/16:0-PC+blood nutriCA+blood 0 -0.500563625 0 serum_phospholipids serum_bileacids 0.00079 0.726 no up up no no no 16:0/16:1-PI+blood nutriCA+blood 0.56992556 0 0 serum_phospholipids serum_bileacids 0.262 0.726 no no no no no no 16:0/18:1-PC+blood nutriCA+blood 0 0 -0.436121627 serum_phospholipids serum_bileacids 6.15E-07 0.726 up up up no no no 16:0/20:5-PG+blood nutriCA+blood -0.464057035 0 0 serum_phospholipids serum_bileacids 0.00656 0.726 no up no no no no 16:0/22:6-PC+blood nutriCA+blood -0.479937313 0 0 serum_phospholipids serum_bileacids 4.53E-05 0.726 no up up no no no 16:1/16:1-PC+blood nutriCA+blood -0.608744019 0 0 serum_phospholipids serum_bileacids 0.0177 0.726 no no up no no no 16:1/18:1-PG+blood nutriCA+blood -0.453470182 0 0 serum_phospholipids serum_bileacids 3.21E-05 0.726 no up up no no no 17-HDOHE+blood nutriCA+blood 0 -0.548529813 0 serum_ARA serum_bileacids 0.62 0.726 no no no no no no 18:0-LPC+blood nutriCA+blood 0 0.609238622 0 serum_phospholipids serum_bileacids 0.554 0.726 no no no no no no 18:0/16:0-PC+blood nutriCA+blood -0.478172838 0 -0.40047262 serum_phospholipids serum_bileacids 9.64E-07 0.726 up up up no no no 18:0/18:0-PC+blood nutriCA+blood -0.499346543 0 0 serum_phospholipids serum_bileacids 0.426 0.726 no no no no no no 18:0/18:1-PC+blood nutriCA+blood -0.464057035 0 0 serum_phospholipids serum_bileacids 0.393 0.726 no no no no no no 18:0/20:4-PC+blood nutriCA+blood -0.451705707 0 0 serum_phospholipids serum_bileacids 0.454 0.726 no no no no no no 18:0/20:4-PI+blood nutriCA+blood -0.538165002 0 0 serum_phospholipids serum_bileacids 0.167 0.726 no no no no no no 18:1/16:0-PI+blood nutriCA+blood 0 0 -0.404639387 serum_phospholipids serum_bileacids 0.793 0.726 no no no no no no 18:1/18:0-PS+blood nutriCA+blood -0.5311071 0 0 serum_phospholipids serum_bileacids 0.193 0.726 no no no no no no 18:1/18:1-PG+blood nutriCA+blood -0.460528084 0 0 serum_phospholipids serum_bileacids 0.00352 0.726 no up up no no no 18:1/20:3-PC+blood nutriCA+blood 0 0.53020226 0 serum_phospholipids serum_bileacids 0.00872 0.726 no up up no no no 18:1/20:4-PC+blood nutriCA+blood -0.568161084 0 0 serum_phospholipids serum_bileacids 0.582 0.726 no no no no no no 18:1/20:4-PE+blood nutriCA+blood -0.444647805 0 0 serum_phospholipids serum_bileacids 0.0578 0.726 up no no no no no 18:1/22:6-PE+blood nutriCA+blood -0.48523074 0 0 serum_phospholipids serum_bileacids 0.0047 0.726 no up no no no no 18:2-LPA+blood nutriCA+blood 0 -0.513736352 0 serum_phospholipids serum_bileacids 0.00684 0.726 dn no up no no no 18:2-LPE+blood nutriCA+blood 0.536400527 0 0 serum_phospholipids serum_bileacids 0.112 0.726 no no no no no no 18:3-LPC+blood nutriCA+blood 0.481701789 0 0 serum_phospholipids serum_bileacids 0.147 0.726 no no no no no no 18:3n3+blood nutriCA+blood -0.474643887 0 0 serum_fattyacid serum_bileacids 0.291 0.726 no no no no no no 20:0-LPC+blood nutriCA+blood 0 0.543374987 0 serum_phospholipids serum_bileacids 0.199 0.726 no no no no no no 20:0/20:5-PC+blood nutriCA+blood -0.682851986 0 0 serum_phospholipids serum_bileacids 0.882 0.726 no no no no no no 20:1-LPA+blood nutriCA+blood 0 -0.536788624 0 serum_phospholipids serum_bileacids 0.0187 0.726 dn dn no no no no 20:1-LPC+blood nutriCA+blood 0 0.490684079 0 serum_phospholipids serum_bileacids 0.217 0.726 no no no no no no 20:1/20:4-PE+blood nutriCA+blood -0.474643887 0 0 serum_phospholipids serum_bileacids 0.0042 0.726 up up no no no no 20:3-LPC+blood nutriCA+blood 0 0.628997713 0 serum_phospholipids serum_bileacids 0.0292 0.726 no up no no no no 20:3/18:0-PC+blood nutriCA+blood -0.492288641 0 0 serum_phospholipids serum_bileacids 0.296 0.726 no no no no no no 20:3/18:0-PI+blood nutriCA+blood -0.456999133 0 0 serum_phospholipids serum_bileacids 0.289 0.726 no no no no no no 20:4-LPA+blood nutriCA+blood 0 0 -0.449084903 serum_phospholipids serum_bileacids 0.398 0.726 no no no no no no 20:4/18:0-PE+blood nutriCA+blood -0.497582067 0 0 serum_phospholipids serum_bileacids 0.000755 0.726 up up no no no no 22:1-LPA+blood nutriCA+blood 0 0 -0.404639387 serum_phospholipids serum_bileacids 0.00373 0.726 no up up no no no 22:2-LPA+blood nutriCA+blood 0 0 -0.415287792 serum_phospholipids serum_bileacids 0.0443 0.726 dn no no no no no 4-hydroxybenzoic acid+stool nutriCA+blood 0 0 -0.525702993 stool_cometabolism serum_bileacids 0.0536 0.726 no dn no no no no acetic acid C2+blood nutriCA+blood -0.546987379 0 0 serum_scfa serum_bileacids 0.000193 0.726 up dn no no no no Adrenergic signaling in cardiomyocytes nutriCA+blood 0 0.569927284 0 kegg serum_bileacids NA 0.726 no no up no no no AGE-RAGE signaling pathway in diabetic complications nutriCA+blood 0 -0.558335543 0 kegg serum_bileacids NA 0.726 no no no no no no Aldosterone synthesis and secretion nutriCA+blood 0 0.624022078 0 kegg serum_bileacids NA 0.726 no up up no no no Alistipes nutriCA+blood 0 0.665630699 0 Genus serum_bileacids 0.0114 0.726 no up no no no no Alzheimer disease nutriCA+blood 0 0.533220103 0 kegg serum_bileacids NA 0.726 no no no no no no Amphetamine addiction nutriCA+blood 0 0.631749905 0 kegg serum_bileacids NA 0.726 no no no no no no AMPK signaling pathway nutriCA+blood 0 0.533220103 0 kegg serum_bileacids NA 0.726 no no no no no no Amyotrophic lateral sclerosis nutriCA+blood 0 0.583450983 0 kegg serum_bileacids NA 0.726 no no no no no no Apelin signaling pathway nutriCA+blood 0.586888759 0.573791198 0 kegg serum_bileacids NA 0.726 no no no no no no Apoptosis nutriCA+blood 0 -0.608566422 0 kegg serum_bileacids NA 0.726 no no no no no no Arginine and proline metabolism nutriCA+blood -0.540107771 -0.562199457 0 kegg serum_bileacids NA 0.726 no up no no no no B cell receptor signaling pathway nutriCA+blood 0 -0.511968578 0 kegg serum_bileacids NA 0.726 no no no no no no Biosynthesis of amino acids nutriCA+blood 0 -0.575723155 0 kegg serum_bileacids NA 0.726 no no no no no no Biosynthesis of cofactors nutriCA+blood 0.461430655 0.546743802 0 kegg serum_bileacids NA 0.726 no no no no no no Bladder cancer nutriCA+blood 0 -0.59117881 0 kegg serum_bileacids NA 0.726 no no no no no no Blautia nutriCA+blood -0.483466264 0 0 acetate-producing Genus serum_bileacids 1.36E-05 0.726 up dn dn no no no C-type lectin receptor signaling pathway nutriCA+blood 0 -0.525492276 0 kegg serum_bileacids NA 0.726 no no no no no no CA+blood nutriCA+blood 0.727237321 0 0.554690739 serum_bileacids serum_bileacids 0.606 0.726 no no no no no no CDCA+blood nutriCA+blood 0.78166261 0.71791362 0.635200502 serum_bileacids serum_bileacids 0.506 0.726 no no no no no no Cell adhesion molecules nutriCA+blood 0 -0.542879888 0 kegg serum_bileacids NA 0.726 no no no no no no Cell cycle nutriCA+blood 0 0.610498379 0 kegg serum_bileacids NA 0.726 no no no no no no cGMP-PKG signaling pathway nutriCA+blood 0 -0.618226207 0 kegg serum_bileacids NA 0.726 no no no no no no Chemokine signaling pathway nutriCA+blood 0 -0.502308793 0 kegg serum_bileacids NA 0.726 no no no no no no Circadian entrainment nutriCA+blood 0 0 0.458853889 kegg serum_bileacids NA 0.726 no up up no no no Coronavirus disease - COVID-19 nutriCA+blood 0.525222911 0.540947931 0 kegg serum_bileacids NA 0.726 no no no no no no Creatinine+blood nutriCA+blood -0.495817592 0 0 serum_choline serum_bileacids 0.437 0.726 no no no no no no Cushing syndrome nutriCA+blood 0 0.513900534 0 kegg serum_bileacids NA 0.726 no no up no no no d18:0-18:3-SM+blood nutriCA+blood 0 0 0.43982542 serum_phospholipids serum_bileacids 0.0879 0.726 no dn no no no no d18:1-18:0-SM+blood nutriCA+blood -0.504639969 0 0 serum_phospholipids serum_bileacids 0.97 0.726 no no no no no no d18:1-18:1-SM+blood nutriCA+blood -0.538165002 0 0 serum_phospholipids serum_bileacids 0.916 0.726 no no no no no no d18:1-20:1-SM+blood nutriCA+blood 0 0 0.51158641 serum_phospholipids serum_bileacids 0.0992 0.726 no no no no no no DCA+blood nutriCA+blood 0.61227297 0.540081806 0.480104169 serum_bileacids serum_bileacids 0.122 0.726 no no no no no no Diabetic cardiomyopathy nutriCA+blood 0 0.533220103 0 kegg serum_bileacids NA 0.726 no no no no no no DPA+blood nutriCA+blood 0 -0.490684079 0 serum_ARA serum_bileacids 0.519 0.726 no no no no no no EGFR tyrosine kinase inhibitor resistance nutriCA+blood 0.637922564 0.569927284 0 kegg serum_bileacids NA 0.726 no no no no no no Endocrine and other factor-regulated calcium reabsorption nutriCA+blood 0 0 0.432164401 kegg serum_bileacids NA 0.726 no no no no no no Epithelial cell signaling in Helicobacter pylori infection nutriCA+blood 0 -0.606634466 0 kegg serum_bileacids NA 0.726 no no no no no no Fc epsilon RI signaling pathway nutriCA+blood 0 -0.61629425 0 kegg serum_bileacids NA 0.726 no no no no no no Fc gamma R-mediated phagocytosis nutriCA+blood -0.62941693 -0.595042724 0 kegg serum_bileacids NA 0.726 no no no no no no Gap junction nutriCA+blood 0 0 0.45782737 kegg serum_bileacids NA 0.726 no no no no no no Glucagon signaling pathway nutriCA+blood 0 0.720619922 0 kegg serum_bileacids NA 0.726 no no no no no no "Glycine, serine and threonine metabolism" nutriCA+blood 0.486947557 0 0 kegg serum_bileacids NA 0.726 no up no no no no HCA+blood nutriCA+blood 0.790367034 0 0.554192222 serum_bileacids serum_bileacids 0.544 0.726 no no no no no no HIF-1 signaling pathway nutriCA+blood 0.561371857 0 0 kegg serum_bileacids NA 0.726 no no no no no no Huntington disease nutriCA+blood 0 0.533220103 0 kegg serum_bileacids NA 0.726 no no no no no no IL-17 signaling pathway nutriCA+blood -0.459304246 -0.683912741 0 kegg serum_bileacids NA 0.726 no no no no no no Inflammatory bowel disease nutriCA+blood 0 -0.508104664 0 kegg serum_bileacids NA 0.726 no no no no no no Inflammatory mediator regulation of TRP channels nutriCA+blood 0 0.699368397 0 kegg serum_bileacids NA 0.726 no no no no no no Influenza A nutriCA+blood 0 -0.676184914 0 kegg serum_bileacids NA 0.726 no no no no no no Insulin secretion nutriCA+blood 0 0 0.401368838 yes kegg serum_bileacids NA 0.726 no up up no no no Insulin signaling pathway nutriCA+blood 0.550739814 0.627885991 0 kegg serum_bileacids NA 0.726 no no no no no no isocapric acid iso-C6+blood nutriCA+blood -0.44641228 0 0 serum_scfa serum_bileacids 0.0458 0.726 no no dn no no no Kaposi sarcoma-associated herpesvirus infection nutriCA+blood 0.457177838 0 0 kegg serum_bileacids NA 0.726 no no dn no no no L-2-Aminobutyric acid+blood nutriCA+blood -0.638740101 0 0 yes serum_aminoacids serum_bileacids 0.000328 0.726 up up no no no no L-Lysine+blood nutriCA+blood -0.518755772 0 0 yes serum_aminoacids serum_bileacids 0.0107 0.726 no up no no no no L-Methionine+blood nutriCA+blood 0 0 -0.448621929 serum_aminoacids serum_bileacids 0.626 0.726 no no no no no no L-Tryptophan+stool nutriCA+blood -0.563720303 0 0 stool_cometabolism serum_bileacids 0.557 0.726 no no no no no no Lipid and atherosclerosis nutriCA+blood -0.610279253 -0.627885991 0 kegg serum_bileacids NA 0.726 no no no no no no Long-term potentiation nutriCA+blood 0 0.546743802 0 kegg serum_bileacids NA 0.726 no no up no no no Lysosome nutriCA+blood 0 -0.610498379 0 kegg serum_bileacids NA 0.726 no no no no no no Melanogenesis nutriCA+blood 0 0.666525129 0 kegg serum_bileacids NA 0.726 no no no no no no Mitophagy - animal nutriCA+blood 0.620911296 0 0 kegg serum_bileacids NA 0.726 no no no no no no Morphine addiction nutriCA+blood 0 0 0.418819657 kegg serum_bileacids NA 0.726 no up up no no no mRNA surveillance pathway nutriCA+blood 0 0.69743644 0 kegg serum_bileacids NA 0.726 no no no no no no mTOR signaling pathway nutriCA+blood 0.678324327 0.569927284 0 kegg serum_bileacids NA 0.726 no no no no no no MUFA%+blood nutriCA+blood -0.455234657 0 -0.431028912 serum_fattyacid serum_bileacids 0.00142 0.726 up no dn no no no Neutrophil extracellular trap formation nutriCA+blood -0.546486997 -0.610498379 0 kegg serum_bileacids NA 0.726 no no no no no no Nicotinate and nicotinamide metabolism nutriCA+blood 0 -0.64140969 0 kegg serum_bileacids NA 0.726 no no no no no no NOD-like receptor signaling pathway nutriCA+blood -0.576256716 -0.539015974 0 kegg serum_bileacids NA 0.726 no no no no no no Olfactory transduction nutriCA+blood -0.595394393 -0.566063371 0 kegg serum_bileacids NA 0.726 no no no no no no Oocyte meiosis nutriCA+blood 0 0.52935619 0 kegg serum_bileacids NA 0.726 no no no no no no Osteoclast differentiation nutriCA+blood 0 -0.64140969 0 kegg serum_bileacids NA 0.726 no no no no no no Oxidative phosphorylation nutriCA+blood 0 0.533220103 0 kegg serum_bileacids NA 0.726 no no no no no no Pancreatic secretion nutriCA+blood 0 0 0.43319092 kegg serum_bileacids NA 0.726 no no no no no no Parkinson disease nutriCA+blood 0.493326783 0 0 kegg serum_bileacids NA 0.726 no no no no no no Pathogenic Escherichia coli infection nutriCA+blood 0 -0.506172707 0 kegg serum_bileacids NA 0.726 no no no no no no Pathways of neurodegeneration - multiple diseases nutriCA+blood 0.486947557 0.508104664 0 kegg serum_bileacids NA 0.726 no no no no no no Peroxisome nutriCA+blood -0.480568332 -0.579587069 0 kegg serum_bileacids NA 0.726 no no no no no no Pertussis nutriCA+blood -0.567751082 -0.566063371 0 kegg serum_bileacids NA 0.726 no no dn no no no Phagosome nutriCA+blood 0 -0.587314897 0 kegg serum_bileacids NA 0.726 no no no no no no PI3K-Akt signaling pathway nutriCA+blood 0 0.537084017 0 yes kegg serum_bileacids NA 0.726 no up up no no no PPAR signaling pathway nutriCA+blood 0 -0.606634466 0 kegg serum_bileacids NA 0.726 no no no no no no Prion disease nutriCA+blood 0 0.533220103 0 kegg serum_bileacids NA 0.726 no no no no no no Prolactin signaling pathway nutriCA+blood 0 -0.566063371 0 kegg serum_bileacids NA 0.726 no no no no no no Protein processing in endoplasmic reticulum nutriCA+blood 0 0.670389043 0 kegg serum_bileacids NA 0.726 no no no no no no Proteoglycans in cancer nutriCA+blood 0.735737357 0.519696405 0 kegg serum_bileacids NA 0.726 no no no no no no Purine metabolism nutriCA+blood 0 0.61629425 0 kegg serum_bileacids NA 0.726 no no no no no no Ras signaling pathway nutriCA+blood 0 0.658797302 0 yes kegg serum_bileacids NA 0.726 no up up no no no Renin secretion nutriCA+blood 0 0.64140969 0 kegg serum_bileacids NA 0.726 no no no no no no Retrograde endocannabinoid signaling nutriCA+blood 0 0.521628362 0 kegg serum_bileacids NA 0.726 no no up no no no Rheumatoid arthritis nutriCA+blood 0 -0.738007534 0 kegg serum_bileacids NA 0.726 no no no no no no Ribosome nutriCA+blood 0.525222911 0.540947931 0 kegg serum_bileacids NA 0.726 no no no no no no Ribosome biogenesis in eukaryotes nutriCA+blood 0 0.519696405 0 kegg serum_bileacids NA 0.726 no no no no no no RNA degradation nutriCA+blood 0 0.668457086 0 kegg serum_bileacids NA 0.726 no no no no no no RNA transport nutriCA+blood 0.495453192 0.540947931 0 kegg serum_bileacids NA 0.726 no no no no no no Roseburia nutriCA+blood 0 0 0.404176413 butyrate-producing Genus serum_bileacids 0.495 0.726 no no no no no no Salmonella infection nutriCA+blood -0.459304246 0 0 kegg serum_bileacids NA 0.726 no no no no no no Shigellosis nutriCA+blood 0.623037704 0 0 kegg serum_bileacids NA 0.726 no no no no no no Spinocerebellar ataxia nutriCA+blood 0 0.564131414 0 kegg serum_bileacids NA 0.726 no no no no no no Staphylococcus aureus infection nutriCA+blood 0 -0.643341647 0 kegg serum_bileacids NA 0.726 up no no no no no Systemic lupus erythematosus nutriCA+blood 0 -0.651069474 0 kegg serum_bileacids NA 0.726 no no no no no no Thermogenesis nutriCA+blood 0 0.533220103 0 kegg serum_bileacids NA 0.726 no no no no no no Thyroid hormone synthesis nutriCA+blood 0 0 0.493755527 kegg serum_bileacids NA 0.726 no no no no no no Toll-like receptor signaling pathway nutriCA+blood 0 -0.633681862 0 yes kegg serum_bileacids NA 0.726 no no no no no no Toxoplasmosis nutriCA+blood -0.625164113 0 0 kegg serum_bileacids NA 0.726 no no no no no no Tuberculosis nutriCA+blood -0.589015168 -0.668457086 0 kegg serum_bileacids NA 0.726 no no dn no no no Ubiquitin mediated proteolysis nutriCA+blood 0.620911296 0.533220103 0 kegg serum_bileacids NA 0.726 no no no no no no Vascular smooth muscle contraction nutriCA+blood 0.491200375 0.508104664 0.439350032 kegg serum_bileacids NA 0.726 no no no no no no Vasopressin-regulated water reabsorption nutriCA+blood 0 0 0.446535664 kegg serum_bileacids NA 0.726 no no no no no no Viral carcinogenesis nutriCA+blood 0 -0.500376836 0 kegg serum_bileacids NA 0.726 no no no no no no Wnt signaling pathway nutriCA+blood 0 0.680048828 0 kegg serum_bileacids NA 0.726 no no no no no no Yersinia infection nutriCA+blood 0 -0.660729259 0 kegg serum_bileacids NA 0.726 no no no no no no 4-hydroxybenzoic acid+stool nutriCA+stool 0 0 0.446640316 stool_cometabolism stool_bileacids 0.0536 0.481 no dn no no no no 5-Hydroxytryptamine+stool nutriCA+stool 0 -0.732412528 0 stool_cometabolism stool_bileacids 0.00862 0.481 dn dn no no no no Adipocytokine signaling pathway nutriCA+stool 0 0 -0.512140034 kegg stool_bileacids NA 0.481 no no no no no no Alistipes nutriCA+stool 0 0.701949861 0 Genus stool_bileacids 0.0114 0.481 no up no no no no Alzheimer disease nutriCA+stool -0.481940144 0 0.655561829 kegg stool_bileacids NA 0.481 no no no no no no Amphetamine addiction nutriCA+stool -0.554179567 0 0 kegg stool_bileacids NA 0.481 no no no no no no AMPK signaling pathway nutriCA+stool 0 0 -0.527950311 kegg stool_bileacids NA 0.481 no no no no no no Amyotrophic lateral sclerosis nutriCA+stool -0.531475748 0 0.68040655 kegg stool_bileacids NA 0.481 no no no no no no Bacteroides nutriCA+stool 0.649122807 0 0 LPS-producing Genus stool_bileacids 0.000267 0.481 dn dn up no no no Biosynthesis of amino acids nutriCA+stool 0.614035088 0 0 kegg stool_bileacids NA 0.481 no no no no no no CA+stool nutriCA+stool 0.669762642 0.718327672 0.790513834 stool_bileacids stool_bileacids 0.827 0.481 no no no no no no Carbon metabolism nutriCA+stool 0.498452012 0.605530071 0 kegg stool_bileacids NA 0.481 no no no no no no Cardiac muscle contraction nutriCA+stool 0 0 0.62055336 kegg stool_bileacids NA 0.481 no no up no no no CDCA+stool nutriCA+stool 0.812177503 0.577479108 0.853754941 stool_bileacids stool_bileacids 0.663 0.481 no no no no no no Central carbon metabolism in cancer nutriCA+stool 0 0.688102353 0 kegg stool_bileacids NA 0.481 no no no no no no Chemical carcinogenesis - receptor activation nutriCA+stool -0.541795666 0 0 kegg stool_bileacids NA 0.481 no no no no no no Clostridium nutriCA+stool 0.589267286 0.91551566 0 Genus stool_bileacids 0.925 0.481 no no no no no no Coprococcus nutriCA+stool 0 0 -0.47826087 butyrate-producing Genus stool_bileacids 0.612 0.481 no no no no no no Coronavirus disease - COVID-19 nutriCA+stool -0.647058824 0 0 kegg stool_bileacids NA 0.481 no no no no no no Cushing syndrome nutriCA+stool -0.64499484 0 0 kegg stool_bileacids NA 0.481 no no up no no no Diabetic cardiomyopathy nutriCA+stool 0 0 0.611518916 kegg stool_bileacids NA 0.481 no no no no no no Eggerthella nutriCA+stool 0 0.655040468 0 Genus stool_bileacids 0.912 0.481 no no no no no no Endocrine resistance nutriCA+stool -0.601651187 0 -0.494071146 kegg stool_bileacids NA 0.481 no no no no no no Fc gamma R-mediated phagocytosis nutriCA+stool 0.64499484 0 0 kegg stool_bileacids NA 0.481 no no no no no no Ferroptosis nutriCA+stool 0 -0.623879467 0 kegg stool_bileacids NA 0.481 no no no no no no FoxO signaling pathway nutriCA+stool 0 0 -0.422924901 kegg stool_bileacids NA 0.481 no no no no no no Fusobacterium nutriCA+stool 0 0 0.545064037 Genus stool_bileacids 0.628 0.481 no no no no no no GABAergic synapse nutriCA+stool 0.517027864 0 0 kegg stool_bileacids NA 0.481 no up up no no no Gap junction nutriCA+stool 0 -0.633054165 0 kegg stool_bileacids NA 0.481 no no no no no no GCA+stool nutriCA+stool 0 0 0.422924901 stool_bileacids stool_bileacids 0.0809 0.481 no no no no no no Glutamatergic synapse nutriCA+stool 0 -0.614704769 0 kegg stool_bileacids NA 0.481 no up up no no no Glycolysis / Gluconeogenesis nutriCA+stool 0 0.761499938 0 kegg stool_bileacids NA 0.481 no no no no no no "Growth hormone synthesis, secretion and action" nutriCA+stool -0.591331269 -0.678927655 -0.438735178 kegg stool_bileacids NA 0.481 no no no no no no HCA+stool nutriCA+stool 0.845201238 0 0.556324111 stool_bileacids stool_bileacids 0.155 0.481 no no no no no no HDCA+stool nutriCA+stool -0.498452012 0 -0.434782609 stool_bileacids stool_bileacids 0.176 0.481 no no no no no no Hepatitis C nutriCA+stool 0 0 -0.549407115 kegg stool_bileacids NA 0.481 no no no no no no HIF-1 signaling pathway nutriCA+stool 0 0.651403561 0 kegg stool_bileacids NA 0.481 no no no no no no Huntington disease nutriCA+stool -0.496388029 0 0.628458498 kegg stool_bileacids NA 0.481 no no no no no no IL-17 signaling pathway nutriCA+stool 0.479876161 0 0 kegg stool_bileacids NA 0.481 no no no no no no Indole-3-Acetic acid+stool nutriCA+stool 0 -0.661988246 0 stool_cometabolism stool_bileacids 0.304 0.481 no no no no no no iso-DCA+stool nutriCA+stool -0.69246646 0 0 stool_bileacids stool_bileacids 0.155 0.481 no no no no no no iso-LCA+stool nutriCA+stool -0.726897361 0 -0.652173913 stool_bileacids stool_bileacids 0.72 0.481 no no no no no no Isobutyric acid+stool nutriCA+stool 0 -0.598606393 -0.527667984 stool_scfa stool_bileacids 0.408 0.481 no no no no no no Isovaleric acid+stool nutriCA+stool -0.473684211 0 -0.54743083 stool_scfa stool_bileacids 0.343 0.481 no no no no no no JAK-STAT signaling pathway nutriCA+stool 0 0 -0.524562394 kegg stool_bileacids NA 0.481 no no no no no no Kynurenic acid+stool nutriCA+stool -0.593395253 -0.676073103 -0.493083004 stool_cometabolism stool_bileacids 0.037 0.481 dn dn no no no no L-Phenylalanine+stool nutriCA+stool 0 0 -0.419960474 stool_cometabolism stool_bileacids 0.398 0.481 no no no no no no L-Tyrosine+stool nutriCA+stool 0 -0.626776106 -0.43083004 stool_cometabolism stool_bileacids 0.44 0.481 no no no no no no LCA+stool nutriCA+stool -0.490196078 0 -0.485177866 stool_bileacids stool_bileacids 0.314 0.481 no no no no no no Lipid and atherosclerosis nutriCA+stool 0.5500516 0 0 kegg stool_bileacids NA 0.481 no no no no no no Long-term potentiation nutriCA+stool 0 0 0.522303783 kegg stool_bileacids NA 0.481 no no up no no no Longevity regulating pathway nutriCA+stool 0 0 -0.446640316 kegg stool_bileacids NA 0.481 no no no no no no Mitophagy - animal nutriCA+stool -0.486068111 0 0 kegg stool_bileacids NA 0.481 no no no no no no Neutrophil extracellular trap formation nutriCA+stool 0.589267286 0 0 kegg stool_bileacids NA 0.481 no no no no no no NOD-like receptor signaling pathway nutriCA+stool 0 0 -0.494071146 kegg stool_bileacids NA 0.481 no no no no no no Non-alcoholic fatty liver disease nutriCA+stool -0.471620227 0 0.507622812 kegg stool_bileacids NA 0.481 no no no no no no Olfactory transduction nutriCA+stool 0.564499484 0 0 kegg stool_bileacids NA 0.481 no no no no no no Oocyte meiosis nutriCA+stool 0 0.669752957 0 kegg stool_bileacids NA 0.481 no no no no no no Oscillospira nutriCA+stool -0.537667699 0 -0.517786561 LPS-producing Genus stool_bileacids 0.62 0.481 no no no no no no Osteoclast differentiation nutriCA+stool 0.475748194 0 0 kegg stool_bileacids NA 0.481 no no no no no no Oxidative phosphorylation nutriCA+stool 0 0 0.605872388 kegg stool_bileacids NA 0.481 no no no no no no "Parathyroid hormone synthesis, secretion and action" nutriCA+stool -0.521155831 0 0 kegg stool_bileacids NA 0.481 no no no no no no Parkinson disease nutriCA+stool -0.539731682 0 0 kegg stool_bileacids NA 0.481 no no no no no no Pathways in cancer nutriCA+stool 0 0 -0.483907397 kegg stool_bileacids NA 0.481 no no no no no no Pathways of neurodegeneration - multiple diseases nutriCA+stool -0.539731682 0 0 kegg stool_bileacids NA 0.481 no no no no no no Peroxisome nutriCA+stool 0.59752322 0 0 kegg stool_bileacids NA 0.481 no no no no no no Pertussis nutriCA+stool 0.770897833 0 0 kegg stool_bileacids NA 0.481 no no dn no no no Phospholipase D signaling pathway nutriCA+stool 0 -0.669752957 0 kegg stool_bileacids NA 0.481 no up up no no no Prion disease nutriCA+stool 0 0 0.607001694 kegg stool_bileacids NA 0.481 no no no no no no Prolactin signaling pathway nutriCA+stool 0 0 -0.47826087 kegg stool_bileacids NA 0.481 no no no no no no Proteasome nutriCA+stool 0 0.623879467 0 kegg stool_bileacids NA 0.481 no no no no no no Proteoglycans in cancer nutriCA+stool 0 0 0.511010728 kegg stool_bileacids NA 0.481 no no no no no no Purine metabolism nutriCA+stool 0 0 -0.434217956 kegg stool_bileacids NA 0.481 no no no no no no Ras signaling pathway nutriCA+stool 0 0 0.445511011 yes kegg stool_bileacids NA 0.481 no up up no no no Regulation of actin cytoskeleton nutriCA+stool 0 0.633054165 0.617165443 kegg stool_bileacids NA 0.481 no no no no no no Retrograde endocannabinoid signaling nutriCA+stool 0 0 0.747035573 kegg stool_bileacids NA 0.481 no no up no no no Ribosome nutriCA+stool -0.657378741 0 0 kegg stool_bileacids NA 0.481 no no no no no no Ruminococcus nutriCA+stool 0.514105115 0 0 Genus stool_bileacids 0.0679 0.481 no no dn no no no Ruminococcus nutriCA+stool 0 0.633818534 0 acetate-producing Genus stool_bileacids 0.335 0.481 no no no no no no Salmonella infection nutriCA+stool 0.560371517 0 0 kegg stool_bileacids NA 0.481 no no no no no no Serotonergic synapse nutriCA+stool 0 -0.807373428 0 kegg stool_bileacids NA 0.481 no no no no no no Signaling pathways regulating pluripotency of stem cells nutriCA+stool -0.488132095 0 0 kegg stool_bileacids NA 0.481 no no no no no no Small cell lung cancer nutriCA+stool 0 0 -0.446640316 kegg stool_bileacids NA 0.481 no no up no no no Staphylococcus aureus infection nutriCA+stool 0.587203302 0 0 kegg stool_bileacids NA 0.481 up no no no no no Systemic lupus erythematosus nutriCA+stool 0.647058824 0 0 kegg stool_bileacids NA 0.481 no no no no no no Thermogenesis nutriCA+stool -0.562435501 0 0.578769057 kegg stool_bileacids NA 0.481 no no no no no no Tuberculosis nutriCA+stool 0.616099071 0 0 kegg stool_bileacids NA 0.481 no no dn no no no Ubiquitin mediated proteolysis nutriCA+stool -0.541795666 0 0 kegg stool_bileacids NA 0.481 no no no no no no Wnt signaling pathway nutriCA+stool 0 0 0.465838509 kegg stool_bileacids NA 0.481 no no no no no no 11-HETE+blood octanoic acid C8+blood 0 0 0.494823889 serum_ARA serum_mcfa 0.464 2.84E-11 no no no dn dn dn 14:1/18:2-PG+blood octanoic acid C8+blood 0 0.495098039 0 serum_phospholipids serum_mcfa 0.00259 2.84E-11 no up up dn dn dn 16:0/20:3-PC+blood octanoic acid C8+blood 0 0.571078431 0.548034188 serum_phospholipids serum_mcfa 5.43E-06 2.84E-11 no up up dn dn dn 16:0/22:6-PC+blood octanoic acid C8+blood 0 0 0.431111111 serum_phospholipids serum_mcfa 4.53E-05 2.84E-11 no up up dn dn dn 16:1/18:1-PG+blood octanoic acid C8+blood 0 0.605392157 0 serum_phospholipids serum_mcfa 3.21E-05 2.84E-11 no up up dn dn dn 16:1/18:2-PG+blood octanoic acid C8+blood 0 0.588235294 0 serum_phospholipids serum_mcfa 1.40E-08 2.84E-11 no up up dn dn dn 18:0-LPA+blood octanoic acid C8+blood 0 0.49754902 0 serum_phospholipids serum_mcfa 0.0725 2.84E-11 no dn no dn dn dn 18:0-LPE+blood octanoic acid C8+blood 0 0 -0.431794872 serum_phospholipids serum_mcfa 0.491 2.84E-11 no no no dn dn dn 18:0/18:2-PC+blood octanoic acid C8+blood 0 0 0.451623932 serum_phospholipids serum_mcfa 1.74E-06 2.84E-11 no up up dn dn dn 18:0+blood octanoic acid C8+blood 0.454135338 0 0 serum_fattyacid serum_mcfa 0.344 2.84E-11 no no no dn dn dn 18:1/18:0-PC+blood octanoic acid C8+blood 0 0 0.445470085 serum_phospholipids serum_mcfa 1.83E-06 2.84E-11 no up up dn dn dn 18:1/18:1-PC+blood octanoic acid C8+blood 0 0.634803922 0.567863248 serum_phospholipids serum_mcfa 1.34E-05 2.84E-11 no up up dn dn dn 18:1/18:2-PG+blood octanoic acid C8+blood 0 0.522058824 0 serum_phospholipids serum_mcfa 5.58E-07 2.84E-11 no up up dn dn dn 18:2-LPE+blood octanoic acid C8+blood 0 0.517156863 0 serum_phospholipids serum_mcfa 0.112 2.84E-11 no no no dn dn dn 18:3/16:0-PE+blood octanoic acid C8+blood -0.464661654 0 -0.410598291 serum_phospholipids serum_mcfa 0.00149 2.84E-11 up up no dn dn dn 18:3n6+blood octanoic acid C8+blood 0 0 -0.433162393 serum_fattyacid serum_mcfa 0.0463 2.84E-11 up no dn dn dn dn 2-methyl-butyric acid m-C4+blood octanoic acid C8+blood 0.526315789 0 0 serum_scfa serum_mcfa 0.262 2.84E-11 no no no dn dn dn 20:0/20:4-PE+blood octanoic acid C8+blood -0.508270677 0 0 serum_phospholipids serum_mcfa 0.00128 2.84E-11 up up no dn dn dn 20:1-LPA+blood octanoic acid C8+blood 0 0.642156863 0 serum_phospholipids serum_mcfa 0.0187 2.84E-11 dn dn no dn dn dn 20:2-LPE+blood octanoic acid C8+blood -0.560902256 0 0 serum_phospholipids serum_mcfa 0.177 2.84E-11 no no no dn dn dn 20:2+blood octanoic acid C8+blood 0 0.588235294 0 serum_fattyacid serum_mcfa 0.478 2.84E-11 no no no dn dn dn 20:5-LPC+blood octanoic acid C8+blood 0 -0.549019608 0 serum_phospholipids serum_mcfa 0.558 2.84E-11 no no no dn dn dn 20:5/18:0-PC+blood octanoic acid C8+blood 0 0 0.468717949 serum_phospholipids serum_mcfa 3.97E-06 2.84E-11 no up up dn dn dn 22:1-LPA+blood octanoic acid C8+blood 0 0.5 0 serum_phospholipids serum_mcfa 0.00373 2.84E-11 no up up dn dn dn 22:2-LPA+blood octanoic acid C8+blood 0 0.524509804 0 serum_phospholipids serum_mcfa 0.0443 2.84E-11 dn no no dn dn dn 24:1+blood octanoic acid C8+blood 0.529323308 0 0 serum_fattyacid serum_mcfa 0.00582 2.84E-11 no dn dn dn dn dn 9-HODE+blood octanoic acid C8+blood 0 0 -0.482393162 serum_ARA serum_mcfa 0.297 2.84E-11 no no no dn dn dn acetic acid C2+blood octanoic acid C8+blood 0.473684211 0 0 serum_scfa serum_mcfa 0.000193 2.84E-11 up dn no dn dn dn butyric acid C4+blood octanoic acid C8+blood 0.484210526 0 0 serum_scfa serum_mcfa 0.407 2.84E-11 no no no dn dn dn capric acid C6+blood octanoic acid C8+blood 0 0.558823529 0.52957265 serum_scfa serum_mcfa 0.433 2.84E-11 no no no dn dn dn Cysteine+blood octanoic acid C8+blood 0 0.536764706 0.496068376 yes serum_aminoacids serum_mcfa 1.81E-07 2.84E-11 dn up up dn dn dn d18:0-16:0-SM+blood octanoic acid C8+blood -0.446616541 0 0 serum_phospholipids serum_mcfa 0.202 2.84E-11 no no no dn dn dn d18:1-16:0-SM+blood octanoic acid C8+blood -0.484210526 0 0 serum_phospholipids serum_mcfa 0.14 2.84E-11 no no no dn dn dn d18:1-20:0-SM+blood octanoic acid C8+blood -0.470676692 0 0 serum_phospholipids serum_mcfa 0.933 2.84E-11 no no no dn dn dn decanoic acid C10+blood octanoic acid C8+blood 0.781954887 0.610294118 0.861880342 serum_mcfa serum_mcfa 6.64E-11 2.84E-11 dn dn no dn dn dn heptanoic acid C7+blood octanoic acid C8+blood 0.983458647 0.659313725 0 serum_mcfa serum_mcfa 8.27E-11 2.84E-11 dn dn no dn dn dn iso-heptanoic acid C7+blood octanoic acid C8+blood 0.454135338 0 0.624615385 serum_mcfa serum_mcfa 0.00256 2.84E-11 up up no dn dn dn isobutyric acid C4+blood octanoic acid C8+blood 0.512781955 0 0 serum_scfa serum_mcfa 0.0151 2.84E-11 up up no dn dn dn L-Asparagine+blood octanoic acid C8+blood 0.520300752 0 0.457777778 serum_aminoacids serum_mcfa 0.784 2.84E-11 no no no dn dn dn L-Isoleucine+blood octanoic acid C8+blood 0 0.50245098 0 yes serum_aminoacids serum_mcfa 5.47E-06 2.84E-11 up up no dn dn dn L-Leucine+blood octanoic acid C8+blood 0 0 0.448888889 yes serum_aminoacids serum_mcfa 3.22E-05 2.84E-11 up up no dn dn dn L-Tryptophan+blood octanoic acid C8+blood 0 0 0.578119658 serum_aminoacids serum_mcfa 0.164 2.84E-11 no no no dn dn dn lauric acid C12+blood octanoic acid C8+blood 0.505263158 0.693627451 0 serum_mcfa serum_mcfa 0.015 2.84E-11 no dn dn dn dn dn n6/n3+blood octanoic acid C8+blood 0 0.531862745 0 serum_fattyacid serum_mcfa 0.226 2.84E-11 no no no dn dn dn nonanoic acid C9+blood octanoic acid C8+blood 0.960902256 0.730392157 0 serum_mcfa serum_mcfa 6.51E-11 2.84E-11 dn dn no dn dn dn 2-Oxocarboxylic acid metabolism Olfactory transduction 0 -0.565217391 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Olfactory transduction 0 -0.675889328 -0.552123552 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Olfactory transduction 0.430434783 0.663043478 0.665379665 kegg kegg NA NA no no no no no no Alistipes Olfactory transduction -0.430571791 0 0 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism Olfactory transduction 0 0.537549407 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Olfactory transduction 0 0 -0.48983269 kegg kegg NA NA no no no no no no AMPK signaling pathway Olfactory transduction -0.655652174 -0.58201581 0 kegg kegg NA NA no no no no no no Antifolate resistance Olfactory transduction 0 -0.43083004 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Olfactory transduction 0 -0.446640316 0 kegg kegg NA NA no no no no no no Apoptosis Olfactory transduction 0 0.479249012 0.573745174 kegg kegg NA NA no no no no no no Arginine and proline metabolism Olfactory transduction 0.586956522 0.682806324 0.535135135 kegg kegg NA NA no up no no no no Arginine biosynthesis Olfactory transduction 0.511304348 0.698616601 0.697039897 kegg kegg NA NA no no no no no no Basal transcription factors Olfactory transduction 0 -0.558300395 0 kegg kegg NA NA no no no no no no Base excision repair Olfactory transduction 0 -0.492094862 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Olfactory transduction 0 0.815217391 0.789446589 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Olfactory transduction -0.473913043 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Olfactory transduction 0 -0.58201581 -0.661003861 kegg kegg NA NA no up up no no no Carbon metabolism Olfactory transduction 0 0.446640316 0.730759331 kegg kegg NA NA no no no no no no Cardiac muscle contraction Olfactory transduction 0 -0.599802372 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Olfactory transduction 0 0.438735178 0 kegg kegg NA NA no no no no no no Cell cycle Olfactory transduction 0 -0.713438735 -0.626254826 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Olfactory transduction 0.802608696 0.887351779 0.671299871 kegg kegg NA NA no no no no no no Chemokine signaling pathway Olfactory transduction 0 0.619565217 0 kegg kegg NA NA no no no no no no Circadian rhythm Olfactory transduction 0 -0.828063241 -0.564478764 kegg kegg NA NA no no no no no no Complement and coagulation cascades Olfactory transduction 0 0.816205534 0.518661519 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Olfactory transduction 0.423478261 0.745059289 0 kegg kegg NA NA no no no no no no DNA replication Olfactory transduction 0 -0.545454545 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Olfactory transduction 0 0 -0.480823681 kegg kegg NA NA no up no no no no ECM-receptor interaction Olfactory transduction -0.409565217 0 -0.425997426 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Olfactory transduction -0.434782609 -0.43972332 0 kegg kegg NA NA no no no no no no Endocrine resistance Olfactory transduction 0 0 -0.411325611 kegg kegg NA NA no no no no no no Endocytosis Olfactory transduction 0 0.500988142 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Olfactory transduction 0 -0.564229249 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Olfactory transduction 0 -0.460474308 -0.403346203 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Olfactory transduction 0.588695652 0.71541502 0.590733591 kegg kegg NA NA no no no no no no Fatty acid degradation Olfactory transduction 0.513913043 0.590909091 0.606692407 kegg kegg NA NA no no no no no no Fatty acid metabolism Olfactory transduction 0.473913043 0.725296443 0.617245817 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Olfactory transduction 0 0.58201581 0.40952381 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Olfactory transduction 0.795652174 0.896245059 0.773230373 kegg kegg NA NA no no no no no no Folate biosynthesis Olfactory transduction 0 -0.666007905 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Olfactory transduction 0.604347826 0 0 kegg kegg NA NA no no no no no no GABAergic synapse Olfactory transduction 0.530434783 0.623517787 0.582496782 kegg kegg NA NA no up up no no no Glutathione metabolism Olfactory transduction -0.482608696 -0.440711462 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Olfactory transduction -0.603478261 0 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Olfactory transduction 0 -0.5 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Olfactory transduction 0 -0.690711462 -0.497554698 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Olfactory transduction 0 0.47826087 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Olfactory transduction 0 -0.481225296 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Olfactory transduction 0 0.717391304 0.704504505 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Olfactory transduction 0 -0.584980237 -0.542342342 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Olfactory transduction 0.526956522 0.480237154 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Olfactory transduction 0.666956522 0.806324111 0.767567568 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Olfactory transduction -0.46 0 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Olfactory transduction 0.474782609 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Olfactory transduction 0 0 0.425482625 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Olfactory transduction 0.61826087 0 0 kegg kegg NA NA no no no no no no Lysine degradation Olfactory transduction -0.484347826 -0.668972332 -0.519433719 kegg kegg NA NA no no no no no no Lysosome Olfactory transduction 0.451304348 0.738142292 0.806435006 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Olfactory transduction -0.463478261 -0.731225296 -0.524839125 kegg kegg NA NA no no no no no no MAPK signaling pathway Olfactory transduction 0.586086957 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Olfactory transduction -0.527826087 -0.497035573 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Olfactory transduction 0 -0.923913043 -0.628056628 kegg kegg NA NA no no no no no no mTOR signaling pathway Olfactory transduction -0.433913043 -0.447628458 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Olfactory transduction 0 -0.716403162 -0.598970399 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Olfactory transduction 0 0.435770751 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Olfactory transduction 0.705217391 0.764822134 0.81029601 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Olfactory transduction 0.595652174 0.868577075 0.713256113 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Olfactory transduction 0.693043478 0.76284585 0.728957529 kegg kegg NA NA no no no no no no Nitrogen metabolism Olfactory transduction 0 0.659090909 0.542599743 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Olfactory transduction 0.670434783 0.499011858 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Olfactory transduction 0 -0.445652174 0 kegg kegg NA NA no no no no no no One carbon pool by folate Olfactory transduction 0 -0.470355731 -0.506048906 kegg kegg NA NA no no no no no no Osteoclast differentiation Olfactory transduction 0.629565217 0.723320158 0.669240669 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Olfactory transduction 0 -0.589920949 -0.471042471 kegg kegg NA NA no no no no no no Oxidative phosphorylation Olfactory transduction 0 -0.564229249 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Olfactory transduction 0.852173913 0.81027668 0.812097812 kegg kegg NA NA no no dn no no no Paraprevotella Olfactory transduction 0 -0.457819866 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Olfactory transduction 0 -0.564229249 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Olfactory transduction 0 0.867588933 0.806177606 kegg kegg NA NA no no no no no no Peroxisome Olfactory transduction 0.660869565 0.725296443 0.64015444 kegg kegg NA NA no no no no no no Phagosome Olfactory transduction 0 0.635375494 0.40978121 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Olfactory transduction 0 0 -0.461518662 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Olfactory transduction -0.532173913 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Olfactory transduction 0 0.555335968 0.612870013 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Olfactory transduction 0 0 0.48030888 kegg kegg NA NA no no no no no no Protein export Olfactory transduction 0 -0.599802372 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Olfactory transduction 0 -0.792490119 0 kegg kegg NA NA no no no no no no Purine metabolism Olfactory transduction -0.573043478 -0.463438735 0 kegg kegg NA NA no no no no no no Ras signaling pathway Olfactory transduction 0 -0.4743083 -0.415186615 yes kegg kegg NA NA no up up no no no Renin-angiotensin system Olfactory transduction 0.726086957 0.763833992 0.724324324 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Olfactory transduction 0 -0.434782609 0 kegg kegg NA NA no no up no no no Ribosome Olfactory transduction -0.497391304 -0.479249012 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Olfactory transduction 0 -0.650197628 -0.545173745 kegg kegg NA NA no no no no no no RNA degradation Olfactory transduction 0 -0.812252964 -0.566795367 kegg kegg NA NA no no no no no no RNA polymerase Olfactory transduction 0 -0.734189723 -0.46975547 kegg kegg NA NA no no no no no no RNA transport Olfactory transduction 0 -0.423913043 0 kegg kegg NA NA no no no no no no Ruminococcus Olfactory transduction -0.525217391 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Signaling pathways regulating pluripotency of stem cells Olfactory transduction 0 -0.583992095 -0.455083655 kegg kegg NA NA no no no no no no Spliceosome Olfactory transduction 0 -0.461462451 -0.473873874 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Olfactory transduction 0.553913043 0.683794466 0.605920206 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Olfactory transduction 0.717391304 0.942687747 0.697297297 kegg kegg NA NA no up up no no no TGF-beta signaling pathway Olfactory transduction 0 -0.43972332 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Olfactory transduction -0.416521739 0 0 kegg kegg NA NA no no no no no no Thermogenesis Olfactory transduction 0 -0.586956522 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Olfactory transduction 0 0.530632411 0 yes kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Olfactory transduction -0.614782609 -0.606719368 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Olfactory transduction 0 -0.660079051 -0.422908623 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Olfactory transduction 0 0.672924901 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Olfactory transduction 0 -0.809288538 -0.516344916 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" One carbon pool by folate 0 -0.597826087 -0.503732304 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism One carbon pool by folate 0 0.515810277 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism One carbon pool by folate 0 -0.668972332 -0.50990991 kegg kegg NA NA no up no no no no Arginine biosynthesis One carbon pool by folate 0 -0.65513834 -0.637323037 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism One carbon pool by folate 0.51826087 0.483201581 0.632689833 kegg kegg NA NA no no no no no no beta-Alanine metabolism One carbon pool by folate 0 0.448616601 0 kegg kegg NA NA no no no no no no Butanoate metabolism One carbon pool by folate 0.546956522 0.770750988 0.520720721 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) One carbon pool by folate 0.732173913 0.7243083 0.695238095 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism One carbon pool by folate 0.771304348 0.663043478 0.613127413 kegg kegg NA NA no no no no no no Ether lipid metabolism One carbon pool by folate 0 0.646245059 0.650707851 kegg kegg NA NA no no no no no no Fatty acid biosynthesis One carbon pool by folate 0 -0.578063241 0 kegg kegg NA NA no no no no no no Glutathione metabolism One carbon pool by folate 0 0.470355731 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism One carbon pool by folate 0 0 0.617503218 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism One carbon pool by folate 0 0 0.683912484 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" One carbon pool by folate 0 0.495059289 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate One carbon pool by folate -0.545217391 -0.500988142 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin One carbon pool by folate 0 0.62055336 0.554182754 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation One carbon pool by folate -0.706956522 -0.432806324 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series One carbon pool by folate 0 0.704545455 0.546460746 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis One carbon pool by folate 0.619130435 0.503952569 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism One carbon pool by folate 0 -0.686758893 -0.615958816 kegg kegg NA NA no no no no no no Histidine metabolism One carbon pool by folate 0.433913043 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism One carbon pool by folate 0.5 0 0.67953668 kegg kegg NA NA no no no no no no Lysine degradation One carbon pool by folate 0 0.43972332 0.664092664 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis One carbon pool by folate 0 0 0.621364221 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis One carbon pool by folate 0.484347826 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis One carbon pool by folate 0.62173913 0.793478261 0.766280566 kegg kegg NA NA no no no no no no Other glycan degradation One carbon pool by folate 0 0 0.545431145 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis One carbon pool by folate 0.437391304 0.479249012 0.744401544 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions One carbon pool by folate 0.611304348 0.766798419 0.711454311 kegg kegg NA NA no no no no no no Pentose phosphate pathway One carbon pool by folate -0.512173913 -0.637351779 -0.581724582 kegg kegg NA NA no no no no no no Phenylalanine metabolism One carbon pool by folate 0 0.746047431 0.415701416 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis One carbon pool by folate 0.783478261 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism One carbon pool by folate 0.730434783 0.588932806 0.541312741 kegg kegg NA NA no no no no no no Purine metabolism One carbon pool by folate 0 0.527667984 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism One carbon pool by folate 0 0.885375494 0 kegg kegg NA NA no no no no no no Pyruvate metabolism One carbon pool by folate 0.870434783 0.677865613 0.433719434 kegg kegg NA NA no no no no no no Selenocompound metabolism One carbon pool by folate 0.440869565 0.583003953 0.810553411 kegg kegg NA NA no no no no no no Sphingolipid metabolism One carbon pool by folate -0.680869565 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism One carbon pool by folate 0 -0.434782609 0 kegg kegg NA NA no no no no no no Steroid biosynthesis One carbon pool by folate 0.54173913 0.732213439 0.613384813 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis One carbon pool by folate 0.457391304 0.752964427 0.567567568 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies One carbon pool by folate 0.868695652 0.864624506 0.659202059 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism One carbon pool by folate 0 0 0.533075933 kegg kegg NA NA no no no no no no Tryptophan metabolism One carbon pool by folate 0.612173913 0.602766798 0 kegg kegg NA NA no up no no no no Tyrosine metabolism One carbon pool by folate 0.628695652 0.856719368 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis One carbon pool by folate 0.706086957 0.861660079 0.753410553 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" One carbon pool by folate 0.780869565 0.833003953 0.65019305 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis One carbon pool by folate 0.412173913 0.698616601 0.691119691 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Oocyte meiosis 0 0.523715415 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Oocyte meiosis -0.406956522 -0.581027668 -0.436550837 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Oocyte meiosis 0 -0.446640316 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Oocyte meiosis 0 0 0.412097812 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Oocyte meiosis 0 0 -0.517374517 kegg kegg NA NA no no no no no no Arginine and proline metabolism Oocyte meiosis 0 -0.528656126 -0.451222651 kegg kegg NA NA no up no no no no Arginine biosynthesis Oocyte meiosis -0.46173913 -0.544466403 -0.527927928 kegg kegg NA NA no no no no no no Bacteroides Oocyte meiosis 0 0.482213439 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Oocyte meiosis 0.668695652 0.491106719 0.683140283 kegg kegg NA NA no no no no no no Base excision repair Oocyte meiosis 0.431304348 0 0.592020592 kegg kegg NA NA no no no no no no beta-Alanine metabolism Oocyte meiosis 0 0.545454545 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Oocyte meiosis -0.52173913 0 -0.6 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Oocyte meiosis 0 0 -0.41956242 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Oocyte meiosis 0 0.62055336 0 kegg kegg NA NA no no no no no no Butanoate metabolism Oocyte meiosis 0 0.793478261 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Oocyte meiosis 0 -0.64229249 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Oocyte meiosis 0 0.457509881 -0.423166023 kegg kegg NA NA no no no no no no Cell cycle Oocyte meiosis 0.726956522 0.493083004 0.828828829 kegg kegg NA NA no no no no no no Chemokine signaling pathway Oocyte meiosis 0 -0.498023715 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Oocyte meiosis 0 0.833992095 0 kegg kegg NA NA no no no no no no Clostridium Oocyte meiosis 0 0.564418232 0 Genus kegg 0.925 NA no no no no no no Cysteine and methionine metabolism Oocyte meiosis 0.513043478 0.866600791 0.573487773 kegg kegg NA NA no no no no no no DNA replication Oocyte meiosis 0.531304348 0.681818182 0.526383526 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Oocyte meiosis 0 0.693675889 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Oocyte meiosis 0 0.731225296 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Oocyte meiosis 0 0.598814229 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Oocyte meiosis 0 -0.53458498 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Oocyte meiosis 0.473043478 0 0.646846847 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Oocyte meiosis 0 -0.574110672 0 kegg kegg NA NA no no no no no no Fatty acid elongation Oocyte meiosis 0 0.690711462 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Oocyte meiosis 0 -0.455533597 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Oocyte meiosis -0.529565217 -0.670948617 -0.562419562 kegg kegg NA NA no no no no no no Galactose metabolism Oocyte meiosis -0.533043478 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Oocyte meiosis 0 0.446640316 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Oocyte meiosis -0.433913043 -0.537549407 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Oocyte meiosis 0 -0.420948617 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Oocyte meiosis 0 0 -0.452509653 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Oocyte meiosis 0 0.757905138 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Oocyte meiosis -0.657391304 -0.825098814 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Oocyte meiosis 0 0 0.4002574 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Oocyte meiosis -0.487826087 -0.52173913 -0.55984556 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Oocyte meiosis 0 0.653162055 0 kegg kegg NA NA no no no no no no Homologous recombination Oocyte meiosis 0 0 0.632432432 kegg kegg NA NA no no no no no no Lysine degradation Oocyte meiosis 0 0 0.463063063 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Oocyte meiosis 0 0 0.41956242 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Oocyte meiosis 0 0.720355731 0 kegg kegg NA NA no no no no no no Mismatch repair Oocyte meiosis 0 0.727272727 0.498069498 kegg kegg NA NA no no no no no no mRNA surveillance pathway Oocyte meiosis 0.51826087 0 0.642213642 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Oocyte meiosis 0.411304348 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Oocyte meiosis 0.602608696 0.635375494 0.648648649 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Oocyte meiosis 0 0 -0.422651223 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Oocyte meiosis 0 -0.750988142 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Oocyte meiosis 0 -0.635375494 -0.567310167 kegg kegg NA NA no no no no no no Nitrogen metabolism Oocyte meiosis -0.655652174 -0.543478261 -0.474646075 kegg kegg NA NA no no no no no no Non-homologous end-joining Oocyte meiosis 0 0.798418972 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Oocyte meiosis 0.565217391 0.651185771 0.598712999 kegg kegg NA NA no no no no no no One carbon pool by folate Oocyte meiosis 0.467826087 0.5256917 0.462805663 kegg kegg NA NA no no no no no no Other glycan degradation Oocyte meiosis 0 -0.435770751 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Oocyte meiosis 0 0 0.536164736 kegg kegg NA NA no no no no no no Oxidative phosphorylation Oocyte meiosis 0.453913043 0.461462451 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Oocyte meiosis 0 0 -0.467953668 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Oocyte meiosis 0 0.769762846 0.461003861 kegg kegg NA NA no no no no no no Pentose phosphate pathway Oocyte meiosis -0.711304348 0 -0.716602317 kegg kegg NA NA no no no no no no Phenylalanine metabolism Oocyte meiosis 0 0.618577075 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Oocyte meiosis 0.591304348 0 0.642471042 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Oocyte meiosis -0.424347826 -0.871541502 0 kegg kegg NA NA no up up no no no Platinum drug resistance Oocyte meiosis 0 0 0.445559846 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Oocyte meiosis 0 0 -0.461776062 kegg kegg NA NA no no no no no no PPAR signaling pathway Oocyte meiosis 0 -0.447628458 -0.453796654 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Oocyte meiosis 0 0.798418972 0 kegg kegg NA NA no no no no no no Propanoate metabolism Oocyte meiosis 0 0.839920949 0.465637066 kegg kegg NA NA no no no no no no Proteasome Oocyte meiosis 0 0.803359684 0 kegg kegg NA NA no no no no no no Protein export Oocyte meiosis 0.808695652 0.778656126 0.635006435 kegg kegg NA NA no no no no no no Pyrimidine metabolism Oocyte meiosis 0 0.519762846 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Oocyte meiosis 0 0.801383399 0 kegg kegg NA NA no no no no no no Ras signaling pathway Oocyte meiosis 0.584347826 0.694664032 0.689317889 yes kegg kegg NA NA no up up no no no Retinol metabolism Oocyte meiosis 0 0.48715415 0 kegg kegg NA NA no no no no no no Ribosome Oocyte meiosis 0.49826087 0.552371542 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Oocyte meiosis 0.557391304 0.436758893 0.722265122 kegg kegg NA NA no no no no no no RNA degradation Oocyte meiosis 0.515652174 0.532608696 0.693178893 kegg kegg NA NA no no no no no no RNA polymerase Oocyte meiosis 0.651304348 0.502964427 0.477734878 kegg kegg NA NA no no no no no no RNA transport Oocyte meiosis 0 0.632411067 0.422136422 kegg kegg NA NA no no no no no no Spliceosome Oocyte meiosis 0.447826087 0 0.720978121 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Oocyte meiosis -0.475652174 -0.505928854 -0.473359073 kegg kegg NA NA no no no no no no Steroid biosynthesis Oocyte meiosis 0.672173913 0.717391304 0.471042471 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Oocyte meiosis 0 0.563241107 0 kegg kegg NA NA no no no no no no Sulfur metabolism Oocyte meiosis 0 0.415019763 -0.61003861 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Oocyte meiosis 0.46 0.679841897 0.619305019 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Oocyte meiosis 0 -0.666996047 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Oocyte meiosis 0.690434783 0.584980237 0.601801802 kegg kegg NA NA no no no no no no Thiamine metabolism Oocyte meiosis 0 0.713438735 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Oocyte meiosis 0 0.760869565 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Oocyte meiosis 0 0.650197628 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Oocyte meiosis 0 0.616600791 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Oocyte meiosis 0 0.692687747 0.441956242 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Oocyte meiosis 0.577391304 0.609683794 0.629086229 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Osteoclast differentiation 0 -0.616600791 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Osteoclast differentiation -0.490434783 -0.769762846 -0.451737452 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Osteoclast differentiation 0.57826087 0.769762846 0.551608752 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Osteoclast differentiation 0.428695652 0.561264822 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Osteoclast differentiation 0 -0.483201581 -0.558558559 kegg kegg NA NA no no no no no no AMPK signaling pathway Osteoclast differentiation -0.548695652 -0.561264822 0 kegg kegg NA NA no no no no no no Antifolate resistance Osteoclast differentiation 0 -0.510869565 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Osteoclast differentiation -0.424347826 -0.703557312 -0.488288288 kegg kegg NA NA no no no no no no Apoptosis Osteoclast differentiation 0.713043478 0.84486166 0.713256113 kegg kegg NA NA no no no no no no Arginine and proline metabolism Osteoclast differentiation 0.680869565 0.7756917 0.728442728 kegg kegg NA NA no up no no no no Arginine biosynthesis Osteoclast differentiation 0.665217391 0.77173913 0.640669241 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Osteoclast differentiation 0 -0.420948617 0 kegg kegg NA NA no no no no no no Autophagy - animal Osteoclast differentiation 0 0.711462451 0 kegg kegg NA NA no no no no no no Basal transcription factors Osteoclast differentiation 0 -0.559288538 -0.644787645 kegg kegg NA NA no no no no no no Base excision repair Osteoclast differentiation 0 -0.571146245 -0.740797941 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Osteoclast differentiation 0.470434783 0.786561265 0.653796654 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Osteoclast differentiation -0.5 -0.721343874 0 kegg kegg NA NA no no no no no no Butanoate metabolism Osteoclast differentiation 0 -0.624505929 -0.557271557 kegg kegg NA NA no no no no no no Calcium signaling pathway Osteoclast differentiation -0.480869565 -0.541501976 0 kegg kegg NA NA no up up no no no Carbon metabolism Osteoclast differentiation 0 0 0.461261261 kegg kegg NA NA no no no no no no Cardiac muscle contraction Osteoclast differentiation 0 -0.696640316 -0.413899614 kegg kegg NA NA no no up no no no Cell cycle Osteoclast differentiation -0.42 -0.773715415 -0.741827542 kegg kegg NA NA no no no no no no Cellular senescence Osteoclast differentiation 0 0.701581028 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Osteoclast differentiation 0.569565217 0.874505929 0.622136422 kegg kegg NA NA no no no no no no Chemokine signaling pathway Osteoclast differentiation 0 0.682806324 0.575289575 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Osteoclast differentiation 0 -0.633399209 -0.422651223 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Osteoclast differentiation 0 -0.592885375 -0.696267696 kegg kegg NA NA no no no no no no DNA replication Osteoclast differentiation 0 -0.785573123 -0.658429858 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Osteoclast differentiation 0 -0.77173913 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Osteoclast differentiation 0 -0.669960474 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Osteoclast differentiation 0 -0.588932806 -0.417760618 kegg kegg NA NA no no no no no no Endocrine resistance Osteoclast differentiation -0.57826087 0 0 kegg kegg NA NA no no no no no no Endocytosis Osteoclast differentiation 0.423478261 0.688735178 0.413899614 kegg kegg NA NA no no no no no no Ether lipid metabolism Osteoclast differentiation 0 -0.618577075 -0.588931789 kegg kegg NA NA no no no no no no Fanconi anemia pathway Osteoclast differentiation 0 -0.510869565 -0.675160875 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Osteoclast differentiation 0.579130435 0.83201581 0.631917632 kegg kegg NA NA no no no no no no Fatty acid degradation Osteoclast differentiation 0.466086957 0.622529644 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Osteoclast differentiation 0.472173913 0.633399209 0 kegg kegg NA NA no no no no no no Folate biosynthesis Osteoclast differentiation 0 -0.506916996 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Osteoclast differentiation 0 0.503952569 0 kegg kegg NA NA no no no no no no Galactose metabolism Osteoclast differentiation 0 0.62944664 0 kegg kegg NA NA no no no no no no Glutathione metabolism Osteoclast differentiation -0.5 -0.783596838 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Osteoclast differentiation 0.464347826 0 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Osteoclast differentiation -0.548695652 -0.611660079 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Osteoclast differentiation 0.695652174 0.652173913 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Osteoclast differentiation 0 -0.475296443 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Osteoclast differentiation 0.588695652 0.564229249 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Osteoclast differentiation 0 -0.510869565 -0.497554698 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Osteoclast differentiation 0 -0.442687747 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Osteoclast differentiation 0.600869565 0.799407115 0.665122265 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Osteoclast differentiation 0 -0.516798419 -0.467181467 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Osteoclast differentiation 0 -0.504940711 0 kegg kegg NA NA no no no no no no Homologous recombination Osteoclast differentiation 0 0 -0.687258687 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Osteoclast differentiation 0 0 -0.423938224 kegg kegg NA NA no no no no no no Lysine degradation Osteoclast differentiation 0 0 -0.471042471 kegg kegg NA NA no no no no no no Lysosome Osteoclast differentiation 0.744347826 0.732213439 0.76010296 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Osteoclast differentiation 0 0 -0.475160875 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Osteoclast differentiation 0 -0.672924901 0 kegg kegg NA NA no no no no no no Mismatch repair Osteoclast differentiation 0 -0.640316206 -0.574774775 kegg kegg NA NA no no no no no no Mitophagy - animal Osteoclast differentiation -0.494782609 -0.583992095 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Osteoclast differentiation 0 -0.763833992 -0.586357786 kegg kegg NA NA no no no no no no mTOR signaling pathway Osteoclast differentiation 0 -0.580039526 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Osteoclast differentiation -0.553913043 -0.826086957 -0.686743887 kegg kegg NA NA no no no no no no Necroptosis Osteoclast differentiation -0.429565217 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Osteoclast differentiation 0.614782609 0.748023715 0.755469755 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Osteoclast differentiation 0.555652174 0.712450593 0.535649936 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Osteoclast differentiation 0.73826087 0.854743083 0.820592021 kegg kegg NA NA no no no no no no Nitrogen metabolism Osteoclast differentiation 0.606956522 0.687747036 0.619305019 kegg kegg NA NA no no no no no no Nucleotide excision repair Osteoclast differentiation 0 -0.735177866 -0.776576577 kegg kegg NA NA no no no no no no One carbon pool by folate Osteoclast differentiation -0.410434783 -0.747035573 -0.740540541 kegg kegg NA NA no no no no no no Oocyte meiosis Osteoclast differentiation -0.432173913 -0.4743083 -0.597425997 kegg kegg NA NA no no no no no no Other glycan degradation Osteoclast differentiation 0.426086957 0 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Osteoclast differentiation 0 0 -0.553667954 kegg kegg NA NA no no no no no no Oxidative phosphorylation Osteoclast differentiation 0 -0.700592885 0 kegg kegg NA NA no no no no no no p53 signaling pathway Osteoclast differentiation 0 0 -0.481853282 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Osteoclast differentiation 0.753913043 0.834980237 0.630888031 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Osteoclast differentiation 0 -0.730237154 -0.559330759 kegg kegg NA NA no no no no no no Pentose phosphate pathway Osteoclast differentiation 0.735652174 0.81916996 0.749034749 kegg kegg NA NA no no no no no no Peroxisome Osteoclast differentiation 0.599130435 0.764822134 0.453281853 kegg kegg NA NA no no no no no no Phagosome Osteoclast differentiation 0 0.72826087 0.537194337 kegg kegg NA NA no no no no no no Phenylalanine metabolism Osteoclast differentiation 0 -0.551383399 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Osteoclast differentiation 0 0 -0.500900901 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Osteoclast differentiation 0 0.543478261 0.403088803 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Osteoclast differentiation 0 0 -0.44993565 yes kegg kegg NA NA no up up no no no Platinum drug resistance Osteoclast differentiation 0 0 -0.472586873 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Osteoclast differentiation -0.466956522 -0.571146245 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Osteoclast differentiation 0.485217391 0.828063241 0.848906049 kegg kegg NA NA no no no no no no Propanoate metabolism Osteoclast differentiation 0 -0.537549407 -0.598970399 kegg kegg NA NA no no no no no no Proteasome Osteoclast differentiation 0 -0.422924901 0 kegg kegg NA NA no no no no no no Protein export Osteoclast differentiation -0.56 -0.701581028 -0.52020592 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Osteoclast differentiation -0.646956522 -0.880434783 -0.476190476 kegg kegg NA NA no no no no no no Purine metabolism Osteoclast differentiation -0.552173913 -0.640316206 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Osteoclast differentiation 0 -0.721343874 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Osteoclast differentiation 0 -0.696640316 -0.598970399 kegg kegg NA NA no no no no no no Ras signaling pathway Osteoclast differentiation 0 -0.669960474 -0.461003861 yes kegg kegg NA NA no up up no no no Retinol metabolism Osteoclast differentiation 0 -0.496047431 -0.4002574 kegg kegg NA NA no no no no no no Ribosome Osteoclast differentiation -0.574782609 -0.65513834 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Osteoclast differentiation -0.507826087 -0.673913043 -0.732303732 kegg kegg NA NA no no no no no no RNA degradation Osteoclast differentiation 0 -0.798418972 -0.567310167 kegg kegg NA NA no no no no no no RNA polymerase Osteoclast differentiation -0.551304348 -0.788537549 -0.732303732 kegg kegg NA NA no no no no no no RNA transport Osteoclast differentiation 0 -0.486166008 0 kegg kegg NA NA no no no no no no Ruminococcus Osteoclast differentiation -0.63826087 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Sarcina Osteoclast differentiation 0 0.422326513 0 Genus kegg 0.0703 NA no no no no no no Selenocompound metabolism Osteoclast differentiation 0 0 -0.505534106 kegg kegg NA NA no no no no no no Sphingolipid metabolism Osteoclast differentiation 0.560869565 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Osteoclast differentiation 0 0.673913043 0 kegg kegg NA NA no no no no no no Spliceosome Osteoclast differentiation 0 0 -0.548519949 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Osteoclast differentiation 0.764347826 0.794466403 0.454826255 kegg kegg NA NA no no no no no no Steroid biosynthesis Osteoclast differentiation -0.567826087 -0.45256917 -0.64967825 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Osteoclast differentiation 0 -0.435770751 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Osteoclast differentiation 0 -0.586956522 -0.610553411 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Osteoclast differentiation 0 0 -0.522007722 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Osteoclast differentiation 0 -0.566205534 -0.407207207 kegg kegg NA NA no no no no no no Thiamine metabolism Osteoclast differentiation 0 -0.566205534 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Osteoclast differentiation 0 -0.64229249 -0.417245817 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Osteoclast differentiation 0 -0.598814229 -0.631145431 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Osteoclast differentiation -0.586086957 -0.712450593 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Osteoclast differentiation 0 -0.632411067 -0.567824968 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Osteoclast differentiation 0 -0.660079051 -0.513513514 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Osteoclast differentiation -0.492173913 -0.651185771 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Osteoclast differentiation 0 0.488142292 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Osteoclast differentiation 0 -0.813241107 -0.462033462 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Other glycan degradation 0 0 0.675160875 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Other glycan degradation 0 0 0.436293436 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Other glycan degradation 0.612173913 0.684782609 0.41956242 kegg kegg NA NA no no no no no no Galactose metabolism Other glycan degradation 0.564347826 0.524703557 0.677220077 kegg kegg NA NA no no no no no no Glutathione metabolism Other glycan degradation 0 -0.583992095 -0.53951094 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Other glycan degradation 0 0 -0.570913771 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Other glycan degradation 0 -0.493083004 0 kegg kegg NA NA no no no no no no Histidine metabolism Other glycan degradation 0.457391304 0 0.413899614 kegg kegg NA NA no no no no no no Lysine degradation Other glycan degradation 0 0.668972332 0.694208494 kegg kegg NA NA no no no no no no Oxidative phosphorylation Other glycan degradation 0 -0.528656126 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Other glycan degradation 0 0 0.500900901 kegg kegg NA NA no no no no no no Pentose phosphate pathway Other glycan degradation 0.412173913 0 0 kegg kegg NA NA no no no no no no Purine metabolism Other glycan degradation 0 0 -0.601801802 kegg kegg NA NA no no no no no no Pyrimidine metabolism Other glycan degradation 0 0 0.487258687 kegg kegg NA NA no no no no no no Selenocompound metabolism Other glycan degradation 0 0.536561265 0.658429858 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Other glycan degradation 0.555652174 0 0.401544402 kegg kegg NA NA no no no no no no Steroid biosynthesis Other glycan degradation -0.442608696 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Other glycan degradation 0 0 0.428571429 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Other glycan degradation 0 0.678853755 0.519433719 kegg kegg NA NA no no no no no no Arginine biosynthesis Other types of O-glycan biosynthesis 0 0 -0.548005148 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Other types of O-glycan biosynthesis 0 0 0.505019305 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Other types of O-glycan biosynthesis 0 0 0.445302445 kegg kegg NA NA no no no no no no Fatty acid elongation Other types of O-glycan biosynthesis 0 -0.460474308 0 kegg kegg NA NA no no no no no no Glutathione metabolism Other types of O-glycan biosynthesis 0 0 -0.466409266 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Other types of O-glycan biosynthesis 0 -0.414031621 0 kegg kegg NA NA no no no no no no Lysine degradation Other types of O-glycan biosynthesis 0.8 0.914031621 0.907593308 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Other types of O-glycan biosynthesis 0 0.477272727 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Other types of O-glycan biosynthesis 0.584347826 0 0.697297297 kegg kegg NA NA no no no no no no Other glycan degradation Other types of O-glycan biosynthesis 0 0.570158103 0.653024453 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Other types of O-glycan biosynthesis 0 0 0.434234234 kegg kegg NA NA no no no no no no Pentose phosphate pathway Other types of O-glycan biosynthesis -0.473913043 -0.690711462 -0.604890605 kegg kegg NA NA no no no no no no Purine metabolism Other types of O-glycan biosynthesis 0 0.434782609 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Other types of O-glycan biosynthesis 0 0 0.463320463 kegg kegg NA NA no no no no no no Selenocompound metabolism Other types of O-glycan biosynthesis 0.73826087 0.803359684 0.862805663 kegg kegg NA NA no no no no no no Steroid biosynthesis Other types of O-glycan biosynthesis 0 0 0.489060489 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Other types of O-glycan biosynthesis 0 0 0.506048906 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Other types of O-glycan biosynthesis 0 0 0.527413127 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Other types of O-glycan biosynthesis 0.6 0.714426877 0.567567568 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Other types of O-glycan biosynthesis 0 0 0.508622909 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Other types of O-glycan biosynthesis 0.459130435 0.41798419 0.653281853 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Ovarian steroidogenesis 0 0 -0.565765766 kegg kegg NA NA no no no no up up Adrenergic signaling in cardiomyocytes Ovarian steroidogenesis 0.456521739 0.513833992 0 kegg kegg NA NA no no up no up up "Alanine, aspartate and glutamate metabolism" Ovarian steroidogenesis -0.484347826 0 0 kegg kegg NA NA no no no no up up alpha-Linolenic acid metabolism Ovarian steroidogenesis 0 0 -0.512741313 kegg kegg NA NA no no no no up up AMPK signaling pathway Ovarian steroidogenesis 0.449565217 0.418972332 0.54028314 kegg kegg NA NA no no no no up up Antigen processing and presentation Ovarian steroidogenesis -0.496521739 0 0 kegg kegg NA NA no no no no up up Arachidonic acid metabolism Ovarian steroidogenesis 0 0.579051383 0 kegg kegg NA NA no no no no up up Arginine and proline metabolism Ovarian steroidogenesis -0.474782609 0 0 kegg kegg NA NA no up no no up up Arginine biosynthesis Ovarian steroidogenesis -0.469565217 0 0 kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism Ovarian steroidogenesis 0 0 -0.674903475 kegg kegg NA NA no no no no up up Autophagy - animal Ovarian steroidogenesis -0.411304348 0 -0.406692407 kegg kegg NA NA no no no no up up Autophagy - other Ovarian steroidogenesis 0 0 -0.417245817 kegg kegg NA NA no no no no up up B cell receptor signaling pathway Ovarian steroidogenesis -0.513913043 0 0 kegg kegg NA NA no no no no up up Basal transcription factors Ovarian steroidogenesis 0 0 -0.405405405 kegg kegg NA NA no no no no up up Biosynthesis of cofactors Ovarian steroidogenesis 0.429565217 0 0.567567568 kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway Ovarian steroidogenesis -0.477391304 0 0 kegg kegg NA NA no no no no up up Calcium signaling pathway Ovarian steroidogenesis 0 0.538537549 0 kegg kegg NA NA no up up no up up cAMP signaling pathway Ovarian steroidogenesis 0 0 0.537709138 yes kegg kegg NA NA no up up no up up Carbon metabolism Ovarian steroidogenesis 0 -0.591897233 0 kegg kegg NA NA no no no no up up Cell adhesion molecules Ovarian steroidogenesis 0 -0.579051383 0 kegg kegg NA NA no no no no up up Cholinergic synapse Ovarian steroidogenesis 0 0 -0.42985843 kegg kegg NA NA no no no no up up Circadian entrainment Ovarian steroidogenesis 0.772173913 0.60770751 0.766023166 kegg kegg NA NA no up up no up up Citrate cycle (TCA cycle) Ovarian steroidogenesis 0 0 -0.605662806 kegg kegg NA NA no no no no up up DNA replication Ovarian steroidogenesis 0 0 -0.419047619 kegg kegg NA NA no no no no up up Dopaminergic synapse Ovarian steroidogenesis 0.523478261 0.653162055 0.470785071 kegg kegg NA NA no up no no up up Drug metabolism - other enzymes Ovarian steroidogenesis 0 0 -0.574259974 kegg kegg NA NA no no no no up up Endocrine resistance Ovarian steroidogenesis 0.732173913 0.756916996 0.713770914 kegg kegg NA NA no no no no up up Endocytosis Ovarian steroidogenesis 0 -0.501976285 0 kegg kegg NA NA no no no no up up Ether lipid metabolism Ovarian steroidogenesis 0 0 -0.404890605 kegg kegg NA NA no no no no up up Fanconi anemia pathway Ovarian steroidogenesis 0 0 -0.412097812 kegg kegg NA NA no no no no up up Fatty acid biosynthesis Ovarian steroidogenesis -0.505217391 0 0 kegg kegg NA NA no no no no up up Fatty acid degradation Ovarian steroidogenesis -0.495652174 0 -0.402574003 kegg kegg NA NA no no no no up up Fatty acid metabolism Ovarian steroidogenesis -0.466086957 0 0 kegg kegg NA NA no no no no up up Fc gamma R-mediated phagocytosis Ovarian steroidogenesis -0.427826087 -0.441699605 0 kegg kegg NA NA no no no no up up Ferroptosis Ovarian steroidogenesis 0.465217391 0.588932806 0.507078507 kegg kegg NA NA no no no no up up GABAergic synapse Ovarian steroidogenesis -0.43826087 0 0 kegg kegg NA NA no up up no up up Galactose metabolism Ovarian steroidogenesis 0 0 -0.639382239 kegg kegg NA NA no no no no up up Gap junction Ovarian steroidogenesis 0.852173913 0.806324111 0.87001287 kegg kegg NA NA no no no no up up Glutamatergic synapse Ovarian steroidogenesis 0.615652174 0.599802372 0.812870013 kegg kegg NA NA no up up no up up Glutathione metabolism Ovarian steroidogenesis 0 0.436758893 0.49009009 kegg kegg NA NA no no no no up up Glycerolipid metabolism Ovarian steroidogenesis 0 0 -0.608494208 kegg kegg NA NA no no up no up up Glycerophospholipid metabolism Ovarian steroidogenesis 0 0 -0.571171171 kegg kegg NA NA no no up no up up "Glycine, serine and threonine metabolism" Ovarian steroidogenesis 0.467826087 0.451581028 0.575289575 kegg kegg NA NA no up no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Ovarian steroidogenesis 0 0 -0.642213642 kegg kegg NA NA no no no no up up Glycosaminoglycan degradation Ovarian steroidogenesis 0 0 -0.701415701 kegg kegg NA NA no no up no up up Glyoxylate and dicarboxylate metabolism Ovarian steroidogenesis -0.564347826 0 0 kegg kegg NA NA no no no no up up GnRH signaling pathway Ovarian steroidogenesis 0.610434783 0.742094862 0.623680824 kegg kegg NA NA no no no no up up Hedgehog signaling pathway Ovarian steroidogenesis 0 0 -0.426512227 kegg kegg NA NA no no no no up up Hematopoietic cell lineage Ovarian steroidogenesis 0 -0.483201581 0 kegg kegg NA NA no no no no up up Hippo signaling pathway Ovarian steroidogenesis 0.464347826 0 0 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Ovarian steroidogenesis -0.444347826 0 -0.510939511 kegg kegg NA NA no no no no up up Histidine metabolism Ovarian steroidogenesis 0 0 -0.463320463 kegg kegg NA NA no no no no up up IL-17 signaling pathway Ovarian steroidogenesis -0.479130435 0 0 kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels Ovarian steroidogenesis 0.615652174 0.548418972 0.567567568 kegg kegg NA NA no no no no up up Inositol phosphate metabolism Ovarian steroidogenesis 0 0 -0.50990991 kegg kegg NA NA no no no no up up Insulin secretion Ovarian steroidogenesis 0.757391304 0.745059289 0.694723295 yes kegg kegg NA NA no up up no up up Insulin signaling pathway Ovarian steroidogenesis 0 0 -0.404633205 kegg kegg NA NA no no no no up up Intestinal immune network for IgA production Ovarian steroidogenesis 0 -0.428853755 0 kegg kegg NA NA no no no no up up Long-term depression Ovarian steroidogenesis 0.708695652 0.722332016 0.915057915 kegg kegg NA NA no no no no up up Longevity regulating pathway Ovarian steroidogenesis 0 0 0.453024453 kegg kegg NA NA no no no no up up Longevity regulating pathway - multiple species Ovarian steroidogenesis 0 -0.545454545 0 kegg kegg NA NA no no no no up up Lysine degradation Ovarian steroidogenesis 0 0 -0.49034749 kegg kegg NA NA no no no no up up Lysosome Ovarian steroidogenesis 0 -0.419960474 0 kegg kegg NA NA no no no no up up Mannose type O-glycan biosynthesis Ovarian steroidogenesis 0 0 -0.472329472 kegg kegg NA NA no no no no up up MAPK signaling pathway Ovarian steroidogenesis 0 0 -0.576061776 kegg kegg NA NA no no no no up up Mitophagy - animal Ovarian steroidogenesis 0.431304348 0.509881423 0 kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis Ovarian steroidogenesis 0 -0.449604743 0 kegg kegg NA NA no no no no up up Natural killer cell mediated cytotoxicity Ovarian steroidogenesis 0 -0.425889328 0 kegg kegg NA NA no no no no up up Necroptosis Ovarian steroidogenesis 0.539130435 0.593873518 0.530759331 kegg kegg NA NA no no no no up up Neuroactive ligand-receptor interaction Ovarian steroidogenesis 0 -0.515810277 0 kegg kegg NA NA up up up no up up NF-kappa B signaling pathway Ovarian steroidogenesis -0.63826087 0 0 kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Ovarian steroidogenesis -0.559130435 0 0 kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Ovarian steroidogenesis -0.637391304 0 0 kegg kegg NA NA no no no no up up Notch signaling pathway Ovarian steroidogenesis 0 0 -0.571171171 kegg kegg NA NA no no no no up up Osteoclast differentiation Ovarian steroidogenesis -0.582608696 -0.420948617 0 kegg kegg NA NA no no no no up up Other glycan degradation Ovarian steroidogenesis -0.491304348 0 -0.572972973 kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis Ovarian steroidogenesis 0 0 -0.452252252 kegg kegg NA NA no no no no up up Pentose and glucuronate interconversions Ovarian steroidogenesis 0 0 -0.464607465 kegg kegg NA NA no no no no up up Peroxisome Ovarian steroidogenesis -0.60173913 0 0 kegg kegg NA NA no no no no up up Phagosome Ovarian steroidogenesis 0 -0.464426877 0 kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system Ovarian steroidogenesis 0 0 -0.425997426 kegg kegg NA NA no no no no up up Phospholipase D signaling pathway Ovarian steroidogenesis 0 0 0.441184041 kegg kegg NA NA no up up no up up Platelet activation Ovarian steroidogenesis 0.584347826 0 0.414414414 kegg kegg NA NA no no no no up up Porphyrin and chlorophyll metabolism Ovarian steroidogenesis 0.448695652 0 0.555469755 kegg kegg NA NA no no no no up up PPAR signaling pathway Ovarian steroidogenesis -0.560869565 -0.462450593 0 kegg kegg NA NA no no no no up up Proteasome Ovarian steroidogenesis -0.429565217 0 -0.557014157 kegg kegg NA NA no no no no up up Purine metabolism Ovarian steroidogenesis 0 0.424901186 0 kegg kegg NA NA no no no no up up Pyrimidine metabolism Ovarian steroidogenesis 0 0 -0.406949807 kegg kegg NA NA no no no no up up Rap1 signaling pathway Ovarian steroidogenesis 0.413043478 0 0 kegg kegg NA NA no no no no up up Renin-angiotensin system Ovarian steroidogenesis -0.433043478 -0.41798419 0 kegg kegg NA NA no no no no up up Retinol metabolism Ovarian steroidogenesis 0 0 -0.555984556 kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes Ovarian steroidogenesis 0 0 -0.402316602 kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway Ovarian steroidogenesis -0.57826087 0 0 kegg kegg NA NA no no no no up up RNA degradation Ovarian steroidogenesis 0 0 -0.489060489 kegg kegg NA NA no no no no up up Selenocompound metabolism Ovarian steroidogenesis 0 0 -0.512998713 kegg kegg NA NA no no no no up up Serotonergic synapse Ovarian steroidogenesis 0.673043478 0.77173913 0.748262548 kegg kegg NA NA no no no no up up SNARE interactions in vesicular transport Ovarian steroidogenesis -0.545217391 0 0 kegg kegg NA NA no no no no up up Sphingolipid metabolism Ovarian steroidogenesis 0 0 -0.52998713 kegg kegg NA NA no no no no up up Sphingolipid signaling pathway Ovarian steroidogenesis 0 -0.515810277 -0.414157014 kegg kegg NA NA no no no no up up Starch and sucrose metabolism Ovarian steroidogenesis 0 0 -0.493436293 kegg kegg NA NA no no no no up up Steroid biosynthesis Ovarian steroidogenesis 0.42 0 0 kegg kegg NA NA no no no no up up Steroid hormone biosynthesis Ovarian steroidogenesis 0 0 -0.6002574 kegg kegg NA NA no no no no up up T cell receptor signaling pathway Ovarian steroidogenesis 0 -0.437747036 0 kegg kegg NA NA no no no no up up Taste transduction Ovarian steroidogenesis 0 0 -0.523037323 kegg kegg NA NA no no up no up up Terpenoid backbone biosynthesis Ovarian steroidogenesis 0 0 -0.525868726 kegg kegg NA NA no no no no up up Th1 and Th2 cell differentiation Ovarian steroidogenesis 0 -0.553359684 -0.481595882 kegg kegg NA NA no no no no up up Th17 cell differentiation Ovarian steroidogenesis 0 -0.605731225 -0.486743887 kegg kegg NA NA no no no no up up Tryptophan metabolism Ovarian steroidogenesis 0 0 -0.55006435 kegg kegg NA NA no up no no up up Ubiquitin mediated proteolysis Ovarian steroidogenesis 0.473913043 0.505928854 0 kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" Ovarian steroidogenesis 0 0 -0.402831403 kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Ovarian steroidogenesis 0.483478261 0.491106719 0.592792793 kegg kegg NA NA no no no no up up VEGF signaling pathway Ovarian steroidogenesis 0 0 -0.427799228 kegg kegg NA NA no no no no up up Wnt signaling pathway Ovarian steroidogenesis 0 0 -0.443758044 kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) Oxidative phosphorylation 0 0.416007905 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Oxidative phosphorylation -0.415652174 -0.79743083 -0.546460746 kegg kegg NA NA no no no no no no Fatty acid degradation Oxidative phosphorylation -0.615652174 -0.860671937 0 kegg kegg NA NA no no no no no no Fatty acid elongation Oxidative phosphorylation -0.473913043 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Oxidative phosphorylation -0.752173913 -0.598814229 -0.515830116 kegg kegg NA NA no no no no no no Galactose metabolism Oxidative phosphorylation -0.735652174 -0.756916996 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Oxidative phosphorylation -0.59826087 0.448616601 0 kegg kegg NA NA no no no no no no Oscillospira Oxidative phosphorylation 0 -0.506916996 0 LPS-producing Genus kegg 0.62 NA no no no no no no Pentose and glucuronate interconversions Oxidative phosphorylation 0 0.527667984 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Oxidative phosphorylation -0.495652174 -0.526679842 -0.429343629 kegg kegg NA NA no no no no no no ABC transporters Oxytocin signaling pathway 0 -0.649209486 -0.476705277 kegg kegg NA NA no up up no no no Adherens junction Oxytocin signaling pathway 0.868695652 0.796442688 0.644272844 kegg kegg NA NA no no no no no no Alistipes Oxytocin signaling pathway 0 -0.553245877 0 Genus kegg 0.0114 NA no up no no no no Aminoacyl-tRNA biosynthesis Oxytocin signaling pathway 0 0 -0.403088803 kegg kegg NA NA no no no no no no Anaerostipes Oxytocin signaling pathway 0 -0.46243159 0 butyrate-producing Genus kegg 0.568 NA no no no no no no Apelin signaling pathway Oxytocin signaling pathway -0.471304348 0 0 kegg kegg NA NA no no no no no no Apoptosis Oxytocin signaling pathway 0.48173913 0 0.433976834 kegg kegg NA NA no no no no no no Apoptosis - multiple species Oxytocin signaling pathway -0.534782609 -0.693675889 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Oxytocin signaling pathway 0 0 0.543371943 kegg kegg NA NA no no no no no no Autophagy - animal Oxytocin signaling pathway -0.61826087 -0.616600791 0 kegg kegg NA NA no no no no no no Autophagy - other Oxytocin signaling pathway -0.839130435 -0.896245059 -0.67979408 kegg kegg NA NA no no no no no no Basal transcription factors Oxytocin signaling pathway -0.685217391 -0.431818182 -0.593564994 kegg kegg NA NA no no no no no no Base excision repair Oxytocin signaling pathway -0.565217391 -0.524703557 -0.402574003 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Oxytocin signaling pathway 0 0 0.552638353 kegg kegg NA NA no no no no no no Butyricicoccus Oxytocin signaling pathway -0.554267084 0 0 butyrate-producing Genus kegg 0.852 NA no no no no no no C-type lectin receptor signaling pathway Oxytocin signaling pathway -0.509565217 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Oxytocin signaling pathway 0 0.445652174 0.511454311 kegg kegg NA NA no no no no no no Cell cycle Oxytocin signaling pathway 0 0 -0.561132561 kegg kegg NA NA no no no no no no Circadian entrainment Oxytocin signaling pathway 0.448695652 0.643280632 0.447619048 kegg kegg NA NA no up up no no no Circadian rhythm Oxytocin signaling pathway -0.555652174 -0.564229249 -0.752123552 kegg kegg NA NA no no no no no no Complement and coagulation cascades Oxytocin signaling pathway 0 0 0.541055341 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Oxytocin signaling pathway 0 0 0.416731017 kegg kegg NA NA no no no no no no DNA replication Oxytocin signaling pathway 0 0 -0.458429858 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Oxytocin signaling pathway -0.567826087 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Oxytocin signaling pathway -0.434782609 -0.546442688 -0.443500644 kegg kegg NA NA no no no no no no Estrogen signaling pathway Oxytocin signaling pathway 0 0 0.402059202 kegg kegg NA NA no no no no no no Fanconi anemia pathway Oxytocin signaling pathway 0 -0.502964427 -0.500643501 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Oxytocin signaling pathway 0 0 0.440669241 kegg kegg NA NA no no no no no no Focal adhesion Oxytocin signaling pathway 0.90173913 0.743083004 0.554697555 kegg kegg NA NA no up up no no no Folate biosynthesis Oxytocin signaling pathway 0 0 -0.407722008 kegg kegg NA NA no no no no no no FoxO signaling pathway Oxytocin signaling pathway 0 -0.561264822 0 kegg kegg NA NA no no no no no no Gap junction Oxytocin signaling pathway 0 0 0.552895753 kegg kegg NA NA no no no no no no Glutathione metabolism Oxytocin signaling pathway 0 0 0.424967825 kegg kegg NA NA no no no no no no Glycerolipid metabolism Oxytocin signaling pathway 0 -0.565217391 -0.572458172 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Oxytocin signaling pathway -0.473913043 -0.637351779 -0.618532819 kegg kegg NA NA no no up no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Oxytocin signaling pathway 0.553043478 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Oxytocin signaling pathway 0 0 -0.492406692 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Oxytocin signaling pathway 0 -0.460474308 -0.638095238 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Oxytocin signaling pathway -0.631304348 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Oxytocin signaling pathway 0.824347826 0.635375494 0.501415701 kegg kegg NA NA no no no no no no Homologous recombination Oxytocin signaling pathway 0 -0.639328063 -0.472072072 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Oxytocin signaling pathway 0 -0.649209486 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Oxytocin signaling pathway -0.565217391 0 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Oxytocin signaling pathway 0 -0.572134387 0 kegg kegg NA NA no no no no no no Lachnospira Oxytocin signaling pathway 0 0.743760833 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Leukocyte transendothelial migration Oxytocin signaling pathway 0.762608696 0.708498024 0.699356499 kegg kegg NA NA no no no no no no Linoleic acid metabolism Oxytocin signaling pathway 0 0 -0.425225225 kegg kegg NA NA no no no no no no Long-term potentiation Oxytocin signaling pathway 0 0 -0.427541828 kegg kegg NA NA no no up no no no Lysine degradation Oxytocin signaling pathway -0.667826087 -0.71541502 -0.649163449 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Oxytocin signaling pathway 0 -0.586956522 -0.618275418 kegg kegg NA NA no no no no no no MAPK signaling pathway Oxytocin signaling pathway 0 -0.616600791 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Oxytocin signaling pathway -0.533913043 0 -0.58018018 kegg kegg NA NA no no no no no no mTOR signaling pathway Oxytocin signaling pathway -0.526086957 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Oxytocin signaling pathway 0 -0.755928854 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Oxytocin signaling pathway 0 0 -0.426512227 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Oxytocin signaling pathway -0.423478261 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Oxytocin signaling pathway 0.46 0 0.601801802 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Oxytocin signaling pathway -0.460869565 -0.520750988 0 kegg kegg NA NA no no no no no no Notch signaling pathway Oxytocin signaling pathway 0 0 -0.542342342 kegg kegg NA NA no no no no no no Other glycan degradation Oxytocin signaling pathway 0 -0.564229249 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Oxytocin signaling pathway -0.624347826 -0.671936759 -0.640926641 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Oxytocin signaling pathway 0.446086957 0 0.433976834 kegg kegg NA NA no up up no no no p53 signaling pathway Oxytocin signaling pathway -0.673043478 -0.650197628 -0.605405405 kegg kegg NA NA no no no no no no Pentose phosphate pathway Oxytocin signaling pathway 0 0 0.463835264 kegg kegg NA NA no no no no no no Phagosome Oxytocin signaling pathway 0.479130435 0 0.512226512 kegg kegg NA NA no no no no no no Phenylalanine metabolism Oxytocin signaling pathway 0.615652174 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Oxytocin signaling pathway 0 0 -0.56988417 kegg kegg NA NA no no no no no no Phototransduction Oxytocin signaling pathway 0 0.508893281 0 kegg kegg NA NA no no no no no no Platelet activation Oxytocin signaling pathway 0.931304348 0.850790514 0.736936937 kegg kegg NA NA no no no no no no Platinum drug resistance Oxytocin signaling pathway -0.569565217 -0.741106719 -0.412612613 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Oxytocin signaling pathway 0 0 0.447361647 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Oxytocin signaling pathway -0.515652174 -0.719367589 -0.578120978 kegg kegg NA NA no no no no no no Proteasome Oxytocin signaling pathway -0.546086957 0 0 kegg kegg NA NA no no no no no no Protein export Oxytocin signaling pathway -0.546956522 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Oxytocin signaling pathway 0 0 -0.563706564 kegg kegg NA NA no no no no no no Rap1 signaling pathway Oxytocin signaling pathway 0.84173913 0.87944664 0.703732304 kegg kegg NA NA no no no no no no Ras signaling pathway Oxytocin signaling pathway 0 0 -0.493178893 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Oxytocin signaling pathway 0.685217391 0.57312253 0.468211068 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Oxytocin signaling pathway 0 0.445652174 0 kegg kegg NA NA no no up no no no Ribosome biogenesis in eukaryotes Oxytocin signaling pathway -0.570434783 0 -0.58996139 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Oxytocin signaling pathway -0.61826087 -0.546442688 -0.42960103 kegg kegg NA NA no no no no no no RNA degradation Oxytocin signaling pathway -0.52173913 0 -0.64967825 kegg kegg NA NA no no no no no no RNA polymerase Oxytocin signaling pathway -0.677391304 0 -0.435778636 kegg kegg NA NA no no no no no no Selenocompound metabolism Oxytocin signaling pathway -0.659130435 -0.643280632 -0.566023166 kegg kegg NA NA no no no no no no Serotonergic synapse Oxytocin signaling pathway 0.407826087 0 0.577348777 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Oxytocin signaling pathway 0 -0.714426877 -0.584298584 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Oxytocin signaling pathway 0 -0.622529644 -0.464092664 kegg kegg NA NA no no no no no no Spliceosome Oxytocin signaling pathway -0.733913043 -0.834980237 -0.566280566 kegg kegg NA NA no no no no no no Sulfur metabolism Oxytocin signaling pathway 0.440869565 0 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Oxytocin signaling pathway 0 -0.749011858 -0.503217503 kegg kegg NA NA no no no no no no Taste transduction Oxytocin signaling pathway 0 0 -0.553667954 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Oxytocin signaling pathway 0 -0.62055336 -0.585328185 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Oxytocin signaling pathway 0 0 -0.497554698 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Oxytocin signaling pathway 0.77826087 0.646245059 0 kegg kegg NA NA no no no no no no Tight junction Oxytocin signaling pathway 0.788695652 0.78458498 0.800514801 kegg kegg NA NA no no no no no no TNF signaling pathway Oxytocin signaling pathway -0.486956522 -0.445652174 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Oxytocin signaling pathway 0.442608696 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Oxytocin signaling pathway 0 0 -0.45971686 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Oxytocin signaling pathway 0 0.586956522 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Oxytocin signaling pathway 0 0.506916996 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Oxytocin signaling pathway 0 0 -0.545945946 kegg kegg NA NA no no no no no no 14:0/18:2-PC+blood P-hydroxyhippuric acid+urine 0.541666667 0 0 serum_phospholipids urine_cometabolism 0.102 0.436 no up no no no no 14:0/20:4-PC+blood P-hydroxyhippuric acid+urine 0 0 0.471428571 serum_phospholipids urine_cometabolism 0.486 0.436 no no no no no no 16:0/16:0-PC+blood P-hydroxyhippuric acid+urine 0 -0.67032967 0 serum_phospholipids urine_cometabolism 0.00079 0.436 no up up no no no 16:0/18:0-PC+blood P-hydroxyhippuric acid+urine 0 -0.582417582 0 serum_phospholipids urine_cometabolism 0.521 0.436 no no no no no no 16:0/18:0-PS+blood P-hydroxyhippuric acid+urine 0 -0.626373626 0 serum_phospholipids urine_cometabolism 0.377 0.436 no no no no no no 16:0/18:1-PC+blood P-hydroxyhippuric acid+urine 0 0 -0.494805195 serum_phospholipids urine_cometabolism 6.15E-07 0.436 up up up no no no 16:0/18:2-PC+blood P-hydroxyhippuric acid+urine 0 0 -0.544155844 serum_phospholipids urine_cometabolism 3.24E-06 0.436 no up up no no no 16:0/18:2-PI+blood P-hydroxyhippuric acid+urine 0.610294118 0 0 serum_phospholipids urine_cometabolism 0.269 0.436 no no no no no no 16:0/18:3-PC+blood P-hydroxyhippuric acid+urine 0.56127451 0 0 serum_phospholipids urine_cometabolism 0.00216 0.436 no up up no no no 16:0/22:6-PC+blood P-hydroxyhippuric acid+urine 0 0 -0.67012987 serum_phospholipids urine_cometabolism 4.53E-05 0.436 no up up no no no 16:0+blood P-hydroxyhippuric acid+urine 0 -0.642857143 0 yes serum_fattyacid urine_cometabolism 0.00876 0.436 up no no no no no 16:1/16:0-PC+blood P-hydroxyhippuric acid+urine 0 0 -0.55974026 serum_phospholipids urine_cometabolism 0.0215 0.436 no up up no no no 18:0/16:0-PC+blood P-hydroxyhippuric acid+urine 0 0 -0.479220779 serum_phospholipids urine_cometabolism 9.64E-07 0.436 up up up no no no 18:0/18:2-PI+blood P-hydroxyhippuric acid+urine 0 -0.604395604 0 serum_phospholipids urine_cometabolism 0.179 0.436 no no no no no no 18:0/20:3-PC+blood P-hydroxyhippuric acid+urine 0.588235294 0 0 serum_phospholipids urine_cometabolism 0.0682 0.436 no up no no no no 18:0/20:4-PI+blood P-hydroxyhippuric acid+urine 0 -0.626373626 -0.602597403 serum_phospholipids urine_cometabolism 0.167 0.436 no no no no no no 18:0/22:6-PA+blood P-hydroxyhippuric acid+urine 0 -0.791208791 0 serum_phospholipids urine_cometabolism 0.22 0.436 no no no no no no 18:0/22:6-PC+blood P-hydroxyhippuric acid+urine 0 0 -0.649350649 serum_phospholipids urine_cometabolism 0.0775 0.436 no no up no no no 18:1-LPE+blood P-hydroxyhippuric acid+urine 0 0 0.446753247 serum_phospholipids urine_cometabolism 0.117 0.436 no no no no no no 18:1/16:0-PC+blood P-hydroxyhippuric acid+urine 0 0 -0.525974026 serum_phospholipids urine_cometabolism 2.43E-05 0.436 no up up no no no 18:1/18:2-PG+blood P-hydroxyhippuric acid+urine 0 -0.604395604 0 serum_phospholipids urine_cometabolism 5.58E-07 0.436 no up up no no no 18:3n6+blood P-hydroxyhippuric acid+urine 0 0 0.537662338 serum_fattyacid urine_cometabolism 0.0463 0.436 up no dn no no no 2-hydroxyphenylacetic acid+urine P-hydroxyhippuric acid+urine 0 0 0.619145299 urine_cometabolism urine_cometabolism 0.763 0.436 no no no no no no 20:2/18:0-PC+blood P-hydroxyhippuric acid+urine 0.595588235 0 0 serum_phospholipids urine_cometabolism 0.0427 0.436 no up no no no no 20:3/16:0-PC+blood P-hydroxyhippuric acid+urine -0.50245098 0 0 serum_phospholipids urine_cometabolism 0.00405 0.436 no up up no no no 20:5/18:0-PC+blood P-hydroxyhippuric acid+urine 0 0 -0.479220779 serum_phospholipids urine_cometabolism 3.97E-06 0.436 no up up no no no 22:6n3+blood P-hydroxyhippuric acid+urine 0.56127451 0 -0.594805195 serum_fattyacid urine_cometabolism 0.792 0.436 no no no no no no 24:0+blood P-hydroxyhippuric acid+urine 0 -0.604395604 0 serum_fattyacid urine_cometabolism 0.034 0.436 dn no up no no no 3-(3-Hydroxyphenyl)propanoic acid+stool P-hydroxyhippuric acid+urine 0.569230769 0 0 stool_cometabolism urine_cometabolism 0.33 0.436 no no no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" P-hydroxyhippuric acid+urine 0.545864662 0 0 urine_cometabolism urine_cometabolism 0.0125 0.436 up up no no no no 3-Hydroxytyramine hydrochloride+urine P-hydroxyhippuric acid+urine 0 0 -0.504273504 urine_cometabolism urine_cometabolism 0.288 0.436 no no no no no no 4-hydroxybenzoic acid+urine P-hydroxyhippuric acid+urine 0 0 0.628034188 urine_cometabolism urine_cometabolism 0.52 0.436 no no no no no no 4-Hydroxyphenylacetic acid+urine P-hydroxyhippuric acid+urine 0 0 0.582222222 urine_cometabolism urine_cometabolism 0.0321 0.436 up up no no no no 5-Hydroxyindole-3-acetic Acid+urine P-hydroxyhippuric acid+urine 0 0 -0.409230769 urine_cometabolism urine_cometabolism 0.0405 0.436 no dn dn no no no ACA+blood P-hydroxyhippuric acid+urine -0.495562179 0 0 serum_bileacids urine_cometabolism 0.338 0.436 no no no no no no Acetic acid+stool P-hydroxyhippuric acid+urine 0 0.683333333 0 yes stool_scfa urine_cometabolism 0.0656 0.436 dn no no no no no Adrenergic signaling in cardiomyocytes P-hydroxyhippuric acid+urine -0.49122807 0.635087719 0 kegg urine_cometabolism NA 0.436 no no up no no no Akkermansia P-hydroxyhippuric acid+urine 0 0.466229237 0 acetate-producing Genus urine_cometabolism 0.23 0.436 no no no no no no Alcoholism P-hydroxyhippuric acid+urine 0 0 0.460769231 kegg urine_cometabolism NA 0.436 no no no no no no Aldosterone synthesis and secretion P-hydroxyhippuric acid+urine 0 0.477192982 0 kegg urine_cometabolism NA 0.436 no up up no no no Alzheimer disease P-hydroxyhippuric acid+urine -0.638596491 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Amphetamine addiction P-hydroxyhippuric acid+urine 0 0 0.513846154 kegg urine_cometabolism NA 0.436 no no no no no no Amyotrophic lateral sclerosis P-hydroxyhippuric acid+urine -0.696491228 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Arachidonic acid metabolism P-hydroxyhippuric acid+urine 0 0 0.564615385 kegg urine_cometabolism NA 0.436 no no no no no no Arrhythmogenic right ventricular cardiomyopathy P-hydroxyhippuric acid+urine 0 0 0.404615385 kegg urine_cometabolism NA 0.436 no up up no no no Autophagy - animal P-hydroxyhippuric acid+urine 0 0 -0.434615385 kegg urine_cometabolism NA 0.436 no no no no no no Bacteroides P-hydroxyhippuric acid+urine 0.643609023 0 0 LPS-producing Genus urine_cometabolism 0.000267 0.436 dn dn up no no no Biosynthesis of amino acids P-hydroxyhippuric acid+urine 0.496491228 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Biosynthesis of cofactors P-hydroxyhippuric acid+urine 0 0 0.400769231 kegg urine_cometabolism NA 0.436 no no no no no no Blautia P-hydroxyhippuric acid+urine 0.455639098 0 0 acetate-producing Genus urine_cometabolism 1.36E-05 0.436 up dn dn no no no Butyric acid+stool P-hydroxyhippuric acid+urine 0 0.716666667 0 yes stool_scfa urine_cometabolism 0.102 0.436 dn no no no no no CA+stool P-hydroxyhippuric acid+urine 0 0 0.704850361 stool_bileacids urine_cometabolism 0.827 0.436 no no no no no no Calcium signaling pathway P-hydroxyhippuric acid+urine 0 0.48245614 0 kegg urine_cometabolism NA 0.436 no up up no no no cAMP signaling pathway P-hydroxyhippuric acid+urine -0.578947368 0 0 yes kegg urine_cometabolism NA 0.436 no up up no no no Carbon metabolism P-hydroxyhippuric acid+urine 0.468421053 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Cardiac muscle contraction P-hydroxyhippuric acid+urine -0.710526316 0 0 kegg urine_cometabolism NA 0.436 no no up no no no CDCA+stool P-hydroxyhippuric acid+urine 0 0 0.630546956 stool_bileacids urine_cometabolism 0.663 0.436 no no no no no no Central carbon metabolism in cancer P-hydroxyhippuric acid+urine 0 0 -0.552307692 kegg urine_cometabolism NA 0.436 no no no no no no Chemical carcinogenesis - receptor activation P-hydroxyhippuric acid+urine -0.554385965 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Chemokine signaling pathway P-hydroxyhippuric acid+urine 0 0 0.443076923 kegg urine_cometabolism NA 0.436 no no no no no no Circadian entrainment P-hydroxyhippuric acid+urine -0.494736842 0 0.605384615 kegg urine_cometabolism NA 0.436 no up up no no no Clostridium P-hydroxyhippuric acid+urine 0.591290657 0 0 Genus urine_cometabolism 0.925 0.436 no no no no no no Cocaine addiction P-hydroxyhippuric acid+urine 0 0 0.428461538 kegg urine_cometabolism NA 0.436 no no no no no no Collinsella P-hydroxyhippuric acid+urine 0 0 0.531100412 Genus urine_cometabolism 0.128 0.436 no no no no no no Cortisol synthesis and secretion P-hydroxyhippuric acid+urine 0 0 0.480769231 kegg urine_cometabolism NA 0.436 no no up no no no Cytokine-cytokine receptor interaction P-hydroxyhippuric acid+urine 0 0 0.42 kegg urine_cometabolism NA 0.436 no no no no no no d18:0-16:0-SM+blood P-hydroxyhippuric acid+urine 0 0 0.507792208 serum_phospholipids urine_cometabolism 0.202 0.436 no no no no no no d18:1-16:0-SM+blood P-hydroxyhippuric acid+urine 0 0 0.519480519 serum_phospholipids urine_cometabolism 0.14 0.436 no no no no no no d18:1-16:1-SM+blood P-hydroxyhippuric acid+urine 0 0 0.6 serum_phospholipids urine_cometabolism 0.2 0.436 no no no no no no d18:1-22:1-SM+blood P-hydroxyhippuric acid+urine 0 0 0.535064935 serum_phospholipids urine_cometabolism 0.222 0.436 no no no no no no Diabetic cardiomyopathy P-hydroxyhippuric acid+urine -0.677192982 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Dilated cardiomyopathy P-hydroxyhippuric acid+urine 0 0 0.491538462 kegg urine_cometabolism NA 0.436 no up up no no no Dopaminergic synapse P-hydroxyhippuric acid+urine -0.533333333 0 0 kegg urine_cometabolism NA 0.436 no up no no no no Endocrine and other factor-regulated calcium reabsorption P-hydroxyhippuric acid+urine 0 0.496491228 0.558461538 kegg urine_cometabolism NA 0.436 no no no no no no EPA+blood P-hydroxyhippuric acid+urine 0 0 -0.566233766 serum_ARA urine_cometabolism 0.212 0.436 no no no no no no Ethanolamine+blood P-hydroxyhippuric acid+urine 0 0 -0.554545455 serum_aminoacids urine_cometabolism 0.122 0.436 up no no no no no Gap junction P-hydroxyhippuric acid+urine 0 0 0.65 kegg urine_cometabolism NA 0.436 no no no no no no Gastric acid secretion P-hydroxyhippuric acid+urine 0 0 0.435384615 kegg urine_cometabolism NA 0.436 no no no no no no GDCA+stool P-hydroxyhippuric acid+urine 0 0 0.627715924 stool_bileacids urine_cometabolism 0.656 0.436 no no no no no no Glucagon signaling pathway P-hydroxyhippuric acid+urine 0 0.475438596 0 kegg urine_cometabolism NA 0.436 no no no no no no Glutathione metabolism P-hydroxyhippuric acid+urine 0 0 0.580769231 kegg urine_cometabolism NA 0.436 no no no no no no "Glycine, serine and threonine metabolism" P-hydroxyhippuric acid+urine 0 0 0.42 kegg urine_cometabolism NA 0.436 no up no no no no HCA+blood P-hydroxyhippuric acid+urine 0 0 0.566682089 serum_bileacids urine_cometabolism 0.544 0.436 no no no no no no HDCA+stool P-hydroxyhippuric acid+urine 0 0 -0.682146543 stool_bileacids urine_cometabolism 0.176 0.436 no no no no no no HIF-1 signaling pathway P-hydroxyhippuric acid+urine 0 0 -0.459230769 kegg urine_cometabolism NA 0.436 no no no no no no Hippuric acid+urine P-hydroxyhippuric acid+urine 0 0 -0.537777778 urine_cometabolism urine_cometabolism 0.361 0.436 no no no no no no Homovanillic acid+urine P-hydroxyhippuric acid+urine 0.485714286 0 0 urine_cometabolism urine_cometabolism 0.45 0.436 no no no no no no Huntington disease P-hydroxyhippuric acid+urine -0.633333333 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Hypertrophic cardiomyopathy P-hydroxyhippuric acid+urine 0 0 0.414615385 kegg urine_cometabolism NA 0.436 no up up no no no Hypotaurine+blood P-hydroxyhippuric acid+urine -0.531862745 0 0 serum_aminoacids urine_cometabolism 0.933 0.436 no no no no no no Insulin secretion P-hydroxyhippuric acid+urine 0 0.473684211 0.434615385 yes kegg urine_cometabolism NA 0.436 no up up no no no iso-LCA+stool P-hydroxyhippuric acid+urine 0 0 -0.481940144 stool_bileacids urine_cometabolism 0.72 0.436 no no no no no no Kynurenic acid+urine P-hydroxyhippuric acid+urine 0 0 -0.417435897 urine_cometabolism urine_cometabolism 0.296 0.436 no no no no no no L-Homocystine+blood P-hydroxyhippuric acid+urine -0.654411765 0 0 serum_aminoacids urine_cometabolism 0.197 0.436 no no no no no no L-Lysine+blood P-hydroxyhippuric acid+urine 0 0 -0.496103896 yes serum_aminoacids urine_cometabolism 0.0107 0.436 no up no no no no L-Methionine+blood P-hydroxyhippuric acid+urine -0.536764706 0 -0.548051948 serum_aminoacids urine_cometabolism 0.626 0.436 no no no no no no L-Ornithine+blood P-hydroxyhippuric acid+urine -0.514705882 0 0 serum_aminoacids urine_cometabolism 0.175 0.436 no no no no no no L-Phenylalanine+blood P-hydroxyhippuric acid+urine 0 0 -0.468831169 yes serum_aminoacids urine_cometabolism 0.0103 0.436 up up no no no no LCA+blood P-hydroxyhippuric acid+urine -0.621070094 0 0 serum_bileacids urine_cometabolism 0.884 0.436 no no no no no no Leishmaniasis P-hydroxyhippuric acid+urine 0.50877193 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Long-term depression P-hydroxyhippuric acid+urine -0.50877193 0 0.601538462 kegg urine_cometabolism NA 0.436 no no no no no no MAPK signaling pathway P-hydroxyhippuric acid+urine 0 0 -0.534615385 kegg urine_cometabolism NA 0.436 no no no no no no Melanogenesis P-hydroxyhippuric acid+urine 0 0.521052632 0 kegg urine_cometabolism NA 0.436 no no no no no no MicroRNAs in cancer P-hydroxyhippuric acid+urine 0 0 -0.436923077 kegg urine_cometabolism NA 0.436 no no no no no no Mitophagy - animal P-hydroxyhippuric acid+urine -0.457894737 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Morphine addiction P-hydroxyhippuric acid+urine 0 0 0.506923077 kegg urine_cometabolism NA 0.436 no up up no no no mTOR signaling pathway P-hydroxyhippuric acid+urine 0 0 -0.482307692 kegg urine_cometabolism NA 0.436 no no no no no no n3+blood P-hydroxyhippuric acid+urine 0 0 -0.707792208 serum_fattyacid urine_cometabolism 0.806 0.436 no no no no no no n6/n3+blood P-hydroxyhippuric acid+urine 0 0 0.450649351 serum_fattyacid urine_cometabolism 0.226 0.436 no no no no no no Non-alcoholic fatty liver disease P-hydroxyhippuric acid+urine -0.654385965 0 0.416153846 kegg urine_cometabolism NA 0.436 no no no no no no nutriCA+blood P-hydroxyhippuric acid+urine 0 0 0.524662617 serum_bileacids urine_cometabolism 0.726 0.436 no no no no no no Oscillospira P-hydroxyhippuric acid+urine -0.460150376 0 0 LPS-producing Genus urine_cometabolism 0.62 0.436 no no no no no no Oxidative phosphorylation P-hydroxyhippuric acid+urine -0.677192982 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Pancreatic secretion P-hydroxyhippuric acid+urine -0.547368421 0 0.571538462 kegg urine_cometabolism NA 0.436 no no no no no no "Parathyroid hormone synthesis, secretion and action" P-hydroxyhippuric acid+urine -0.663157895 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Parkinson disease P-hydroxyhippuric acid+urine -0.661403509 0.501754386 0 kegg urine_cometabolism NA 0.436 no no no no no no Pathways of neurodegeneration - multiple diseases P-hydroxyhippuric acid+urine -0.668421053 0.519298246 0 kegg urine_cometabolism NA 0.436 no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer P-hydroxyhippuric acid+urine 0 0 -0.580769231 kegg urine_cometabolism NA 0.436 no no no no no no Peroxisome P-hydroxyhippuric acid+urine 0.550877193 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Phenylacetic acid+stool P-hydroxyhippuric acid+urine -0.582417582 0 0 stool_cometabolism urine_cometabolism 0.785 0.436 no no no no no no PI3K-Akt signaling pathway P-hydroxyhippuric acid+urine 0 0 -0.423846154 yes kegg urine_cometabolism NA 0.436 no up up no no no Platelet activation P-hydroxyhippuric acid+urine 0 0 0.481538462 kegg urine_cometabolism NA 0.436 no no no no no no Prion disease P-hydroxyhippuric acid+urine -0.692982456 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Progesterone-mediated oocyte maturation P-hydroxyhippuric acid+urine 0 0 -0.524615385 kegg urine_cometabolism NA 0.436 no no no no no no Propionic acid+stool P-hydroxyhippuric acid+urine 0 0.7 0 yes stool_scfa urine_cometabolism 0.0436 0.436 dn no up no no no Proteasome P-hydroxyhippuric acid+urine 0 0 -0.420769231 kegg urine_cometabolism NA 0.436 no no no no no no Regulation of lipolysis in adipocytes P-hydroxyhippuric acid+urine 0 0 0.493846154 kegg urine_cometabolism NA 0.436 no no no no no no Renin secretion P-hydroxyhippuric acid+urine 0 0 0.526153846 kegg urine_cometabolism NA 0.436 no no no no no no Retrograde endocannabinoid signaling P-hydroxyhippuric acid+urine -0.503508772 0 0 kegg urine_cometabolism NA 0.436 no no up no no no Ruminococcus P-hydroxyhippuric acid+urine -0.454135338 0 0 acetate-producing Genus urine_cometabolism 0.335 0.436 no no no no no no Serotonergic synapse P-hydroxyhippuric acid+urine -0.501754386 0 0.536923077 kegg urine_cometabolism NA 0.436 no no no no no no SFA+blood P-hydroxyhippuric acid+urine 0 -0.697802198 0 serum_fattyacid urine_cometabolism 0.0386 0.436 up no no no no no Shigellosis P-hydroxyhippuric acid+urine -0.543859649 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Spinocerebellar ataxia P-hydroxyhippuric acid+urine 0 0 -0.533846154 kegg urine_cometabolism NA 0.436 no no no no no no T cell receptor signaling pathway P-hydroxyhippuric acid+urine 0 0 -0.455384615 kegg urine_cometabolism NA 0.436 no no no no no no Taurine+blood P-hydroxyhippuric acid+urine 0 0 -0.48961039 serum_aminoacids urine_cometabolism 0.857 0.436 no no no no no no TCA+blood P-hydroxyhippuric acid+urine 0.589160024 0 0 serum_bileacids urine_cometabolism 0.339 0.436 no no no no no no TCA+stool P-hydroxyhippuric acid+urine 0 0 0.595459236 stool_bileacids urine_cometabolism 0.458 0.436 no no no no no no Th1 and Th2 cell differentiation P-hydroxyhippuric acid+urine 0 -0.464912281 0 kegg urine_cometabolism NA 0.436 no no no no no no Thermogenesis P-hydroxyhippuric acid+urine -0.694736842 0 0 kegg urine_cometabolism NA 0.436 no no no no no no Thyroid hormone synthesis P-hydroxyhippuric acid+urine 0 0 0.693846154 kegg urine_cometabolism NA 0.436 no no no no no no total_stool_scfa+stool P-hydroxyhippuric acid+urine 0 0.933333333 0 stool_scfa urine_cometabolism 0.0534 0.436 dn no up no no no TUDCA+blood P-hydroxyhippuric acid+urine 0.560112034 0 0 yes serum_bileacids urine_cometabolism 0.0282 0.436 no no dn no no no Ubiquitin mediated proteolysis P-hydroxyhippuric acid+urine 0 0.498245614 0 kegg urine_cometabolism NA 0.436 no no no no no no Vascular smooth muscle contraction P-hydroxyhippuric acid+urine -0.484210526 0.498245614 0.456153846 kegg urine_cometabolism NA 0.436 no no no no no no Vasopressin-regulated water reabsorption P-hydroxyhippuric acid+urine 0 0 0.558461538 kegg urine_cometabolism NA 0.436 no no no no no no Vibrio cholerae infection P-hydroxyhippuric acid+urine 0 0 0.419230769 kegg urine_cometabolism NA 0.436 no no no no no no Viral myocarditis P-hydroxyhippuric acid+urine 0 0 0.433846154 kegg urine_cometabolism NA 0.436 no no no no no no Viral protein interaction with cytokine and cytokine receptor P-hydroxyhippuric acid+urine 0 0 0.652307692 kegg urine_cometabolism NA 0.436 no no no no no no ABC transporters p53 signaling pathway 0 0.829051383 0.446846847 kegg kegg NA NA no up up no no no Amino sugar and nucleotide sugar metabolism p53 signaling pathway 0 0.526679842 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis p53 signaling pathway 0 0 0.480823681 kegg kegg NA NA no no no no no no Antifolate resistance p53 signaling pathway 0 0 0.405405405 kegg kegg NA NA no no no no no no Basal transcription factors p53 signaling pathway 0.675652174 0.490118577 0.651480051 kegg kegg NA NA no no no no no no Base excision repair p53 signaling pathway 0.717391304 0.575098814 0.555984556 kegg kegg NA NA no no no no no no Biosynthesis of amino acids p53 signaling pathway -0.489565217 0 -0.544658945 kegg kegg NA NA no no no no no no Carbon metabolism p53 signaling pathway -0.492173913 -0.77173913 -0.529472329 kegg kegg NA NA no no no no no no Cell cycle p53 signaling pathway 0.56173913 0 0.598455598 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway p53 signaling pathway 0 0 -0.41029601 kegg kegg NA NA no no no no no no Chemokine signaling pathway p53 signaling pathway 0 0 -0.647361647 kegg kegg NA NA no no no no no no Clostridium p53 signaling pathway 0 -0.611283284 0 Genus kegg 0.925 NA no no no no no no DNA replication p53 signaling pathway 0 0 0.493693694 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance p53 signaling pathway 0.435652174 0 0 kegg kegg NA NA no no no no no no Endocrine resistance p53 signaling pathway 0 0.43972332 0 kegg kegg NA NA no no no no no no ErbB signaling pathway p53 signaling pathway 0.520869565 0.433794466 0 kegg kegg NA NA no no no no no no Ether lipid metabolism p53 signaling pathway 0 0 0.570913771 kegg kegg NA NA no no no no no no Eubacterium p53 signaling pathway 0 0 0.403984941 Genus kegg 0.0692 NA no no no no no no Fanconi anemia pathway p53 signaling pathway 0.52173913 0.605731225 0.65045045 kegg kegg NA NA no no no no no no Fatty acid elongation p53 signaling pathway 0 -0.441699605 0 kegg kegg NA NA no no no no no no FoxO signaling pathway p53 signaling pathway 0.466956522 0.623517787 0.567824968 kegg kegg NA NA no no no no no no Glycerolipid metabolism p53 signaling pathway 0 0.725296443 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism p53 signaling pathway 0.724347826 0.841897233 0.581981982 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis p53 signaling pathway 0 -0.597826087 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin p53 signaling pathway -0.51826087 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation p53 signaling pathway -0.543478261 0 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - globo and isoglobo series p53 signaling pathway -0.586086957 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis p53 signaling pathway 0.575652174 0.705533597 0.45997426 kegg kegg NA NA no no no no no no Homologous recombination p53 signaling pathway 0.505217391 0.752964427 0.747232947 kegg kegg NA NA no no no no no no Inositol phosphate metabolism p53 signaling pathway 0 0.761857708 0.544144144 kegg kegg NA NA no no no no no no Lachnospira p53 signaling pathway 0 -0.451692626 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Linoleic acid metabolism p53 signaling pathway -0.462608696 0 0 kegg kegg NA NA no no no no no no Lysine degradation p53 signaling pathway 0.572173913 0.672924901 0.527413127 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis p53 signaling pathway 0 0.539525692 0.518661519 kegg kegg NA NA no no no no no no MAPK signaling pathway p53 signaling pathway 0.435652174 0.52173913 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway p53 signaling pathway 0.586956522 0 0.536936937 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis p53 signaling pathway 0 0.448616601 0.451994852 kegg kegg NA NA no no no no no no N-Glycan biosynthesis p53 signaling pathway 0.571304348 0 0.454311454 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction p53 signaling pathway -0.466086957 -0.429841897 -0.505276705 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway p53 signaling pathway 0.426086957 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair p53 signaling pathway 0 0 0.571428571 kegg kegg NA NA no no no no no no One carbon pool by folate p53 signaling pathway 0 0 0.481338481 kegg kegg NA NA no no no no no no Other glycan degradation p53 signaling pathway 0 0.54743083 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis p53 signaling pathway 0.73826087 0.816205534 0.706563707 kegg kegg NA NA no no no no no no Paraprevotella p53 signaling pathway -0.552433694 0 0 Genus kegg 0.118 NA no no no no no no Pentose phosphate pathway p53 signaling pathway -0.528695652 -0.451581028 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism p53 signaling pathway -0.549565217 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system p53 signaling pathway 0.585217391 0.507905138 0.621364221 kegg kegg NA NA no no no no no no Platinum drug resistance p53 signaling pathway 0.856521739 0.821146245 0.775289575 kegg kegg NA NA no no no no no no PPAR signaling pathway p53 signaling pathway 0 0 -0.58018018 kegg kegg NA NA no no no no no no Protein export p53 signaling pathway 0.532173913 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism p53 signaling pathway 0 0 0.505791506 kegg kegg NA NA no no no no no no Rap1 signaling pathway p53 signaling pathway -0.800869565 -0.691699605 -0.654311454 kegg kegg NA NA no no no no no no Ras signaling pathway p53 signaling pathway 0 0 0.464864865 yes kegg kegg NA NA no up up no no no Ribosome biogenesis in eukaryotes p53 signaling pathway 0.70173913 0.427865613 0.581981982 kegg kegg NA NA no no no no no no RNA degradation p53 signaling pathway 0.51826087 0 0.46048906 kegg kegg NA NA no no no no no no RNA polymerase p53 signaling pathway 0.692173913 0 0.540797941 kegg kegg NA NA no no no no no no Selenocompound metabolism p53 signaling pathway 0.842608696 0.684782609 0.712741313 kegg kegg NA NA no no no no no no Sphingolipid metabolism p53 signaling pathway -0.445217391 0 0 kegg kegg NA NA no no no no no no Spliceosome p53 signaling pathway 0.717391304 0.807312253 0.576833977 kegg kegg NA NA no no no no no no Steroid biosynthesis p53 signaling pathway 0 0 0.403346203 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism p53 signaling pathway 0.733043478 0.698616601 0.433462033 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis p53 signaling pathway 0.445217391 0 0.503732304 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis p53 signaling pathway 0 0 0.455855856 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis p53 signaling pathway 0.559130435 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor p53 signaling pathway 0 0 -0.487773488 kegg kegg NA NA no no no no no no 16:1/16:1-PC+blood PAI-1 0 -0.666666667 -0.466956522 yes serum_phospholipids DM-assocaited hormones 0.0177 5.10E-05 no no up up up up 18:0-LPC+blood PAI-1 0 0 0.476521739 yes serum_phospholipids DM-assocaited hormones 0.554 5.10E-05 no no no up up up 18:0/22:6-PA+blood PAI-1 0 -0.541666667 0 yes serum_phospholipids DM-assocaited hormones 0.22 5.10E-05 no no no up up up 18:1/18:1-PC+blood PAI-1 0.558307534 0 0 yes serum_phospholipids DM-assocaited hormones 1.34E-05 5.10E-05 no up up up up up 18:2-LPC+blood PAI-1 0.496388029 0.551470588 0 yes serum_phospholipids DM-assocaited hormones 0.00743 5.10E-05 dn no up up up up 18:2/18:2-PC+blood PAI-1 0.531475748 0 0 yes serum_phospholipids DM-assocaited hormones 1.98E-05 5.10E-05 dn up up up up up 20:0/20:5-PC+blood PAI-1 0 -0.610294118 0 yes serum_phospholipids DM-assocaited hormones 0.882 5.10E-05 no no no up up up 20:0+blood PAI-1 0.673890609 0 0 yes yes serum_fattyacid DM-assocaited hormones 0.000278 5.10E-05 dn no up up up up 20:3/18:0-PC+blood PAI-1 0 -0.595588235 0 yes serum_phospholipids DM-assocaited hormones 0.296 5.10E-05 no no no up up up 20:4-LPC+blood PAI-1 0 0 0.433913043 yes serum_phospholipids DM-assocaited hormones 0.949 5.10E-05 no no no up up up 22:6n3+blood PAI-1 -0.51496388 0 0 yes serum_fattyacid DM-assocaited hormones 0.792 5.10E-05 no no no up up up AA+blood PAI-1 0 0 0.557391304 yes serum_ARA DM-assocaited hormones 0.212 5.10E-05 no no no up up up Alistipes PAI-1 0.520556326 0 0 yes Genus DM-assocaited hormones 0.0114 5.10E-05 no up no up up up Amyotrophic lateral sclerosis PAI-1 0.452286844 0 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up Anaerostipes PAI-1 0 0 -0.479700042 butyrate-producing yes Genus DM-assocaited hormones 0.568 5.10E-05 no no no up up up Butyric acid+stool PAI-1 0 0 0.450649351 yes yes stool_scfa DM-assocaited hormones 0.102 5.10E-05 dn no no up up up C-peptide PAI-1 0.475296443 0 0 yes DM-assocaited hormones DM-assocaited hormones 0.228 5.10E-05 no no no up up up cGMP-PKG signaling pathway PAI-1 -0.425183512 0 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up Chronic myeloid leukemia PAI-1 0 0 0.410093583 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up Cytosolic DNA-sensing pathway PAI-1 0.436476567 0 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up DL-methionine sulfoxide+blood PAI-1 -0.5500516 0 0 yes serum_aminoacids DM-assocaited hormones 0.302 5.10E-05 no no no up up up Ethanolamine+blood PAI-1 0 0 0.527826087 yes serum_aminoacids DM-assocaited hormones 0.122 5.10E-05 up no no up up up Faecalibacterium PAI-1 0 0.420869565 0 butyrate-producing yes Genus DM-assocaited hormones 0.0039 5.10E-05 no dn dn up up up Fc gamma R-mediated phagocytosis PAI-1 -0.463579898 0 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up FGF basic PAI-1 0.681318681 0 0 yes serum_cytokines DM-assocaited hormones 0.65 5.10E-05 no no no up up up GABAergic synapse PAI-1 -0.604743083 0 0 yes kegg DM-assocaited hormones NA 5.10E-05 no up up up up up HDCA+stool PAI-1 0.541176471 0 0 yes stool_bileacids DM-assocaited hormones 0.176 5.10E-05 no no no up up up Hematopoietic cell lineage PAI-1 0 0 -0.44618984 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up Homovanillic acid+urine PAI-1 -0.69246646 0 -0.506916996 yes urine_cometabolism DM-assocaited hormones 0.45 5.10E-05 no no no up up up Hypotaurine+blood PAI-1 0 0 0.5 yes serum_aminoacids DM-assocaited hormones 0.933 5.10E-05 no no no up up up Kaposi sarcoma-associated herpesvirus infection PAI-1 0 0.41798419 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no dn up up up L-Alanine+blood PAI-1 0 0 0.406956522 yes yes serum_aminoacids DM-assocaited hormones 0.00138 5.10E-05 up up no up up up L-Citrulline+blood PAI-1 0 0 0.610434783 yes serum_aminoacids DM-assocaited hormones 0.534 5.10E-05 no no no up up up L-Isoleucine+blood PAI-1 0 0 0.42 yes yes serum_aminoacids DM-assocaited hormones 5.47E-06 5.10E-05 up up no up up up L-Methionine+blood PAI-1 0 0 0.543478261 yes serum_aminoacids DM-assocaited hormones 0.626 5.10E-05 no no no up up up L-Proline+blood PAI-1 0 0 0.405217391 yes yes serum_aminoacids DM-assocaited hormones 0.00265 5.10E-05 up up no up up up L-Tryptophan+blood PAI-1 0 0 0.434782609 yes serum_aminoacids DM-assocaited hormones 0.164 5.10E-05 no no no up up up L-Tryptophan+urine PAI-1 0.671826625 0 0.566205534 yes urine_cometabolism DM-assocaited hormones 0.226 5.10E-05 no no no up up up L-Tyrosine+blood PAI-1 0 0 0.431304348 yes yes serum_aminoacids DM-assocaited hormones 0.00913 5.10E-05 up up no up up up L-Tyrosine+urine PAI-1 0 0 0.522727273 yes urine_cometabolism DM-assocaited hormones 0.45 5.10E-05 no no no up up up Lachnospira PAI-1 -0.470355731 0 0 butyrate-producing yes Genus DM-assocaited hormones 0.279 5.10E-05 no no no up up up Leptin PAI-1 -0.41798419 -0.451304348 0 yes DM-assocaited hormones DM-assocaited hormones 0.706 5.10E-05 no no no up up up Longevity regulating pathway - multiple species PAI-1 0 -0.5 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up Mineral absorption PAI-1 0 0.46541502 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up Mitophagy - animal PAI-1 0 0.479249012 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up Necroptosis PAI-1 0 0.470355731 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up Neutrophil extracellular trap formation PAI-1 -0.429700734 0 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up Olfactory transduction PAI-1 -0.476002259 0 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up Oscillospira PAI-1 0 -0.425217391 0 LPS-producing yes Genus DM-assocaited hormones 0.62 5.10E-05 no no no up up up "Parathyroid hormone synthesis, secretion and action" PAI-1 0 0.477272727 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up PDGF-bb PAI-1 0 0.777922078 0.492063492 yes yes serum_cytokines DM-assocaited hormones 0.111 5.10E-05 no no no up up up Peroxisome PAI-1 -0.649915302 0 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up Phenylacetyl L-GlutaMine+urine PAI-1 0.473684211 0 0 yes urine_cometabolism DM-assocaited hormones 0.0909 5.10E-05 up no no up up up Prevotella PAI-1 0 0 0.426570367 acetate-producing yes Genus DM-assocaited hormones 0.287 5.10E-05 no no no up up up Primary immunodeficiency PAI-1 0 -0.4743083 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up Prostate cancer PAI-1 0 0 0.423128342 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up Rothia PAI-1 0 0 -0.411133216 yes Genus DM-assocaited hormones 0.313 5.10E-05 no no no up up up Ruminococcus PAI-1 0.554347826 0 0 acetate-producing yes Genus DM-assocaited hormones 0.335 5.10E-05 no no no up up up SFA%+blood PAI-1 0.475748194 0 0 yes serum_fattyacid DM-assocaited hormones 0.0236 5.10E-05 no up no up up up Shigellosis PAI-1 0 0.449604743 0 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up TCA+stool PAI-1 -0.551624819 0 -0.463636364 yes stool_bileacids DM-assocaited hormones 0.458 5.10E-05 no no no up up up Toxoplasmosis PAI-1 0 0 -0.407085561 yes kegg DM-assocaited hormones NA 5.10E-05 no no no up up up 2-Oxocarboxylic acid metabolism Pancreatic cancer -0.492173913 0 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Pancreatic cancer 0.410434783 0 0 kegg kegg NA NA no no up no no no African trypanosomiasis Pancreatic cancer 0.484347826 0 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Pancreatic cancer 0.44 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Pancreatic cancer 0.763478261 0.431818182 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Pancreatic cancer -0.568695652 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Pancreatic cancer 0 0.424901186 0.653539254 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Pancreatic cancer -0.64 -0.59486166 0 kegg kegg NA NA no no no no no no Autophagy - animal Pancreatic cancer 0 0 0.413899614 kegg kegg NA NA no no no no no no Autophagy - other Pancreatic cancer 0 0.480237154 0.408494208 kegg kegg NA NA no no no no no no Axon guidance Pancreatic cancer 0.700869565 0 0 kegg kegg NA NA no up up no no no beta-Alanine metabolism Pancreatic cancer -0.482608696 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Pancreatic cancer 0 0 -0.405405405 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Pancreatic cancer -0.579130435 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Pancreatic cancer -0.482608696 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Pancreatic cancer 0.453043478 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Pancreatic cancer 0.524347826 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Pancreatic cancer 0.487826087 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Pancreatic cancer 0.433043478 0.553359684 0 kegg kegg NA NA no no no no no no Carbon metabolism Pancreatic cancer -0.408695652 0 -0.416216216 kegg kegg NA NA no no no no no no Cell cycle Pancreatic cancer 0 0 0.508108108 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Pancreatic cancer 0.548695652 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Pancreatic cancer -0.406956522 -0.472332016 -0.510939511 kegg kegg NA NA no no no no no no Chemokine signaling pathway Pancreatic cancer 0.430434783 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Pancreatic cancer 0.430434783 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Pancreatic cancer 0.504347826 0.435770751 0.428314028 kegg kegg NA NA no no no no no no Collecting duct acid secretion Pancreatic cancer 0 -0.427865613 0 kegg kegg NA NA no no no no no no Colorectal cancer Pancreatic cancer 0.6 0.679841897 0.504247104 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Pancreatic cancer 0.453043478 0 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Pancreatic cancer 0 0 -0.424710425 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Pancreatic cancer -0.406956522 0 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Pancreatic cancer 0 0 -0.441184041 kegg kegg NA NA no no no no no no ErbB signaling pathway Pancreatic cancer 0.613913043 0.606719368 0.47953668 kegg kegg NA NA no no no no no no Fanconi anemia pathway Pancreatic cancer 0 0 0.447619048 kegg kegg NA NA no no no no no no Fat digestion and absorption Pancreatic cancer 0 0 -0.457400257 yes kegg kegg NA NA no up up no no no Fc epsilon RI signaling pathway Pancreatic cancer 0.584347826 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Pancreatic cancer 0.444347826 0 0.614671815 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Pancreatic cancer -0.611304348 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Pancreatic cancer -0.469565217 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Pancreatic cancer -0.48173913 0 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Pancreatic cancer 0 0 0.432689833 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Pancreatic cancer -0.433043478 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Pancreatic cancer -0.488695652 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Pancreatic cancer 0 0.5256917 0.507335907 kegg kegg NA NA no no no no no no GnRH secretion Pancreatic cancer 0.649565217 0.532608696 0.54980695 kegg kegg NA NA no up up no no no Hedgehog signaling pathway Pancreatic cancer 0.53826087 0 0.446332046 kegg kegg NA NA no no no no no no Hepatitis B Pancreatic cancer 0.455652174 0 0 kegg kegg NA NA no no no no no no Hepatitis C Pancreatic cancer 0.522608696 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Pancreatic cancer -0.466086957 0 0 kegg kegg NA NA no no no no no no Homologous recombination Pancreatic cancer 0 0 0.525868726 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Pancreatic cancer 0 0 0.50990991 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Pancreatic cancer 0 0 0.546460746 kegg kegg NA NA no no no no no no Long-term potentiation Pancreatic cancer 0.547826087 0 0 kegg kegg NA NA no no up no no no Mannose type O-glycan biosynthesis Pancreatic cancer 0 0.48715415 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Pancreatic cancer 0 0 0.454311454 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Pancreatic cancer 0 0 -0.46048906 kegg kegg NA NA no no no no no no MicroRNAs in cancer Pancreatic cancer 0 0 0.525868726 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Pancreatic cancer 0 0 0.492406692 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Pancreatic cancer 0 0 0.471557272 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Pancreatic cancer 0.593043478 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Pancreatic cancer 0 0 -0.444787645 kegg kegg NA NA no no no no no no Notch signaling pathway Pancreatic cancer 0.442608696 0 0 kegg kegg NA NA no no no no no no Other glycan degradation Pancreatic cancer -0.440869565 0 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Pancreatic cancer 0 0 0.535649936 kegg kegg NA NA no no no no no no p53 signaling pathway Pancreatic cancer 0 0 0.680823681 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Pancreatic cancer 0 0 -0.51969112 kegg kegg NA NA no no no no no no Pathways in cancer Pancreatic cancer 0.556521739 0 0.516602317 kegg kegg NA NA no no no no no no Phagosome Pancreatic cancer 0 0 -0.441441441 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Pancreatic cancer 0.580869565 0.606719368 0.597168597 kegg kegg NA NA no no no no no no Platinum drug resistance Pancreatic cancer 0 0.531620553 0.688803089 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Pancreatic cancer -0.465217391 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Pancreatic cancer 0 0.462450593 0.413384813 kegg kegg NA NA no no no no no no Prolactin signaling pathway Pancreatic cancer 0.517391304 0 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Pancreatic cancer 0 0 0.400514801 kegg kegg NA NA no no no no no no Pyrimidine metabolism Pancreatic cancer -0.442608696 0 0 kegg kegg NA NA no no no no no no Ras signaling pathway Pancreatic cancer 0.776521739 0 0.475933076 yes kegg kegg NA NA no up up no no no Renal cell carcinoma Pancreatic cancer 0.707826087 0.447628458 0 kegg kegg NA NA no no no no no no Ruminococcus Pancreatic cancer 0 -0.42050649 0 Genus kegg 0.0679 NA no no dn no no no Ruminococcus Pancreatic cancer -0.415652174 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Selenocompound metabolism Pancreatic cancer 0 0 0.461776062 kegg kegg NA NA no no no no no no Serotonergic synapse Pancreatic cancer 0 -0.442687747 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Pancreatic cancer 0.667826087 0.585968379 0.658944659 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Pancreatic cancer 0.81826087 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Pancreatic cancer 0 0.567193676 0 kegg kegg NA NA no no no no no no Spliceosome Pancreatic cancer 0 0.493083004 0.403088803 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Pancreatic cancer -0.447826087 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Pancreatic cancer 0 0 0.453796654 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Pancreatic cancer 0.465217391 0 0.442471042 kegg kegg NA NA no no no no no no Tryptophan metabolism Pancreatic cancer -0.453043478 0 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Pancreatic cancer 0.473043478 0.421936759 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Pancreatic cancer -0.425217391 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Pancreatic cancer -0.466086957 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Pancreatic cancer -0.448695652 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Pancreatic cancer 0.813043478 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Pancreatic cancer 0.470434783 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Pancreatic cancer 0.5 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Pancreatic secretion -0.452173913 0 -0.472329472 kegg kegg NA NA no no no no no no ABC transporters Pancreatic secretion -0.730434783 0 0 kegg kegg NA NA no up up no no no Adherens junction Pancreatic secretion 0 0.616600791 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Pancreatic secretion 0.848695652 0.792490119 0.738996139 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Pancreatic secretion 0 -0.608695652 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Pancreatic secretion -0.543478261 -0.698616601 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Pancreatic secretion 0.893043478 0.822134387 0.863577864 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Pancreatic secretion -0.71826087 -0.593873518 -0.594337194 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Pancreatic secretion -0.643478261 0 -0.483655084 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Pancreatic secretion -0.644347826 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Pancreatic secretion 0 0.51284585 0 kegg kegg NA NA no no no no no no Apoptosis Pancreatic secretion 0 -0.451581028 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Pancreatic secretion -0.570434783 -0.536561265 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Pancreatic secretion -0.533913043 -0.653162055 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Pancreatic secretion 0 0 -0.575032175 kegg kegg NA NA no no no no no no Autophagy - animal Pancreatic secretion 0 -0.628458498 -0.412612613 kegg kegg NA NA no no no no no no Autophagy - other Pancreatic secretion 0 -0.427865613 0 kegg kegg NA NA no no no no no no Axon guidance Pancreatic secretion 0.443478261 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Pancreatic secretion 0 -0.458498024 0 kegg kegg NA NA no no no no no no Base excision repair Pancreatic secretion -0.42173913 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Pancreatic secretion -0.606956522 0 -0.448906049 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Pancreatic secretion -0.547826087 -0.665019763 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Pancreatic secretion -0.453043478 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Pancreatic secretion -0.540869565 0 0 kegg kegg NA NA no no no no no no Butyricimonas Pancreatic secretion 0.498345926 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no C-type lectin receptor signaling pathway Pancreatic secretion 0 -0.574110672 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Pancreatic secretion 0.812173913 0.830039526 0.698326898 kegg kegg NA NA no up up no no no cAMP signaling pathway Pancreatic secretion 0.66173913 0 0.589189189 yes kegg kegg NA NA no up up no no no Carbon metabolism Pancreatic secretion -0.522608696 0 -0.493436293 kegg kegg NA NA no no no no no no Cardiac muscle contraction Pancreatic secretion 0.686086957 0.725296443 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Pancreatic secretion 0 -0.485177866 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Pancreatic secretion 0 -0.526679842 0 kegg kegg NA NA no no no no no no Circadian entrainment Pancreatic secretion 0.659130435 0.735177866 0.846846847 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Pancreatic secretion -0.427826087 0 -0.495238095 kegg kegg NA NA no no no no no no Complement and coagulation cascades Pancreatic secretion 0 -0.499011858 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Pancreatic secretion 0.771304348 0.632411067 0.911196911 kegg kegg NA NA no no up no no no Cushing syndrome Pancreatic secretion 0.748695652 0.621541502 0.772200772 kegg kegg NA NA no no up no no no DNA replication Pancreatic secretion -0.405217391 0 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Pancreatic secretion 0.760869565 0.833992095 0.789446589 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Pancreatic secretion 0 0.422924901 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Pancreatic secretion -0.546086957 0.454545455 -0.61981982 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Pancreatic secretion 0 0.425889328 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Pancreatic secretion 0.924347826 0.914031621 0.931788932 kegg kegg NA NA no no no no no no Endocrine resistance Pancreatic secretion 0.693043478 0.491106719 0.79047619 kegg kegg NA NA no no no no no no Endocytosis Pancreatic secretion 0 -0.461462451 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Pancreatic secretion 0 0 0.478764479 kegg kegg NA NA no no no no no no Ether lipid metabolism Pancreatic secretion 0.451304348 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Pancreatic secretion -0.425217391 0 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Pancreatic secretion -0.493043478 -0.693675889 0 kegg kegg NA NA no no no no no no Fatty acid degradation Pancreatic secretion -0.776521739 -0.796442688 -0.710939511 kegg kegg NA NA no no no no no no Fatty acid elongation Pancreatic secretion -0.41826087 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Pancreatic secretion -0.769565217 -0.759881423 -0.575289575 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Pancreatic secretion 0 -0.546442688 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Pancreatic secretion -0.505217391 -0.649209486 0 kegg kegg NA NA no no no no no no Ferroptosis Pancreatic secretion 0.486956522 0 0 kegg kegg NA NA no no no no no no Focal adhesion Pancreatic secretion 0 0.483201581 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Pancreatic secretion 0 -0.609683794 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Pancreatic secretion -0.65826087 0 -0.623938224 kegg kegg NA NA no no no no no no Galactose metabolism Pancreatic secretion -0.684347826 -0.616600791 -0.669240669 kegg kegg NA NA no no no no no no Gap junction Pancreatic secretion 0.697391304 0.526679842 0.748519949 kegg kegg NA NA no no no no no no Gastric acid secretion Pancreatic secretion 0.476521739 0.763833992 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Pancreatic secretion 0.61826087 0.72826087 0.604633205 kegg kegg NA NA no no no no no no Glutamatergic synapse Pancreatic secretion 0.635652174 0 0.643758044 kegg kegg NA NA no up up no no no Glutathione metabolism Pancreatic secretion 0 0.616600791 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Pancreatic secretion -0.536521739 0 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Pancreatic secretion -0.503478261 0 -0.413384813 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Pancreatic secretion 0 -0.455533597 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Pancreatic secretion 0.623478261 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Pancreatic secretion 0 0 -0.58996139 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Pancreatic secretion -0.687826087 -0.674901186 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Pancreatic secretion 0.811304348 0.652173913 0.863320463 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Pancreatic secretion 0.425217391 0 0.588159588 kegg kegg NA NA no no no no no no Hippo signaling pathway Pancreatic secretion 0 0.583003953 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Pancreatic secretion 0 -0.448616601 -0.421621622 kegg kegg NA NA no no no no no no Histidine metabolism Pancreatic secretion -0.615652174 0 -0.599485199 kegg kegg NA NA no no no no no no Homologous recombination Pancreatic secretion -0.476521739 0 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Pancreatic secretion 0 -0.507905138 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Pancreatic secretion 0.813043478 0.786561265 0.836550837 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Pancreatic secretion -0.494782609 0 0 kegg kegg NA NA no no no no no no Insulin secretion Pancreatic secretion 0.747826087 0.721343874 0.887258687 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Pancreatic secretion 0 0.433794466 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Pancreatic secretion -0.410434783 -0.586956522 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Pancreatic secretion 0 0.458498024 0 kegg kegg NA NA no no no no no no Long-term depression Pancreatic secretion 0.948695652 0.574110672 0.876190476 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Pancreatic secretion 0 -0.528656126 0 kegg kegg NA NA no no no no no no Lysosome Pancreatic secretion 0 0 -0.45045045 kegg kegg NA NA no no no no no no MAPK signaling pathway Pancreatic secretion 0 -0.624505929 -0.40952381 kegg kegg NA NA no no no no no no Melanogenesis Pancreatic secretion 0.822608696 0.864624506 0.890604891 kegg kegg NA NA no no no no no no Mismatch repair Pancreatic secretion -0.473913043 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Pancreatic secretion 0.64173913 0.576086957 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Pancreatic secretion 0.430434783 0.565217391 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Pancreatic secretion 0 -0.541501976 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Pancreatic secretion 0 0.488142292 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Pancreatic secretion 0 -0.42687747 0 kegg kegg NA NA no no no no no no Necroptosis Pancreatic secretion 0.554782609 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Pancreatic secretion 0 -0.54743083 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Pancreatic secretion 0 -0.461462451 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Pancreatic secretion -0.553913043 -0.543478261 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Pancreatic secretion -0.564347826 -0.576086957 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Pancreatic secretion 0 -0.492094862 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Pancreatic secretion -0.606086957 -0.741106719 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Pancreatic secretion 0.679130435 0.693675889 0.507850708 kegg kegg NA NA no no no no no no Non-homologous end-joining Pancreatic secretion -0.523478261 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Pancreatic secretion -0.417391304 0 0 kegg kegg NA NA no no no no no no Odoribacter Pancreatic secretion -0.479268035 0 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Olfactory transduction Pancreatic secretion 0 -0.498023715 -0.469240669 kegg kegg NA NA no no no no no no Oscillospira Pancreatic secretion 0 -0.516798419 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Pancreatic secretion -0.500869565 -0.716403162 0 kegg kegg NA NA no no no no no no Other glycan degradation Pancreatic secretion -0.635652174 0 -0.414671815 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Pancreatic secretion 0.690434783 0.677865613 0.818532819 kegg kegg NA NA no up up no no no Oxidative phosphorylation Pancreatic secretion 0.643478261 0.720355731 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Pancreatic secretion -0.446956522 -0.656126482 -0.553410553 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Pancreatic secretion 0.719130435 0.716403162 0.637837838 kegg kegg NA NA no no no no no no Pentose phosphate pathway Pancreatic secretion 0 -0.510869565 0 kegg kegg NA NA no no no no no no Peroxisome Pancreatic secretion -0.740869565 -0.789525692 0 kegg kegg NA NA no no no no no no Phagosome Pancreatic secretion 0 -0.429841897 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Pancreatic secretion 0 0 0.435521236 kegg kegg NA NA no up up no no no Platelet activation Pancreatic secretion 0 0.617588933 0.406692407 kegg kegg NA NA no no no no no no PPAR signaling pathway Pancreatic secretion 0 -0.749011858 0 kegg kegg NA NA no no no no no no Prevotella Pancreatic secretion 0 0 0.524893876 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Pancreatic secretion -0.526956522 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Pancreatic secretion 0 -0.542490119 0 kegg kegg NA NA no no no no no no Propanoate metabolism Pancreatic secretion -0.455652174 0 0 kegg kegg NA NA no no no no no no Proteasome Pancreatic secretion 0 0 -0.575289575 kegg kegg NA NA no no no no no no Protein export Pancreatic secretion 0 0.498023715 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Pancreatic secretion 0 0.481225296 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Pancreatic secretion 0 0.5256917 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Pancreatic secretion -0.712173913 0 -0.447104247 kegg kegg NA NA no no no no no no Pyruvate metabolism Pancreatic secretion -0.451304348 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Pancreatic secretion 0 0.550395257 0 kegg kegg NA NA no no no no no no Ras signaling pathway Pancreatic secretion 0 0.580039526 0 yes kegg kegg NA NA no up up no no no Regulation of lipolysis in adipocytes Pancreatic secretion 0.783478261 0.735177866 0.904247104 kegg kegg NA NA no no no no no no Relaxin signaling pathway Pancreatic secretion 0.539130435 0 0.557786358 kegg kegg NA NA no no no no no no Renin secretion Pancreatic secretion 0.68 0.801383399 0.847619048 kegg kegg NA NA no no no no no no Renin-angiotensin system Pancreatic secretion 0 -0.519762846 0 kegg kegg NA NA no no no no no no Retinol metabolism Pancreatic secretion -0.55826087 0 -0.434491634 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Pancreatic secretion 0.406086957 0.736166008 0 kegg kegg NA NA no no up no no no Ribosome Pancreatic secretion 0.465217391 0.616600791 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Pancreatic secretion 0 -0.583992095 0 kegg kegg NA NA no no no no no no RNA degradation Pancreatic secretion 0.407826087 0.598814229 0 kegg kegg NA NA no no no no no no RNA transport Pancreatic secretion -0.410434783 0 0 kegg kegg NA NA no no no no no no Salivary secretion Pancreatic secretion 0.677391304 0.597826087 0.649420849 kegg kegg NA NA no no no no no no Serotonergic synapse Pancreatic secretion 0.444347826 0 0.553153153 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Pancreatic secretion -0.642608696 -0.5 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Pancreatic secretion 0 0 -0.473359073 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Pancreatic secretion -0.603478261 -0.660079051 -0.668983269 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Pancreatic secretion 0 0 -0.540540541 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Pancreatic secretion 0 -0.527667984 -0.537451737 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Pancreatic secretion 0 -0.647233202 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Pancreatic secretion 0.457391304 0.530632411 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Pancreatic secretion 0 -0.415019763 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Pancreatic secretion 0 -0.490118577 0 kegg kegg NA NA no no no no no no Thermogenesis Pancreatic secretion 0.702608696 0.712450593 0 kegg kegg NA NA no no no no no no Thiamine metabolism Pancreatic secretion -0.451304348 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Pancreatic secretion 0 0.701581028 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Pancreatic secretion 0.620869565 0.79743083 0.68005148 kegg kegg NA NA no no no no no no Tight junction Pancreatic secretion 0 0.414031621 0 kegg kegg NA NA no no no no no no TNF signaling pathway Pancreatic secretion 0 -0.41798419 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Pancreatic secretion 0 -0.558300395 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Pancreatic secretion -0.616521739 0 -0.494208494 kegg kegg NA NA no up no no no no Type II diabetes mellitus Pancreatic secretion 0 0 -0.412612613 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Pancreatic secretion -0.584347826 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Pancreatic secretion 0.648695652 0.608695652 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Pancreatic secretion -0.588695652 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Pancreatic secretion 0.816521739 0.785573123 0.729472329 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Pancreatic secretion 0.891304348 0.944664032 0.938481338 kegg kegg NA NA no no no no no no Wnt signaling pathway Pancreatic secretion 0.604347826 0.599802372 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Pantothenate and CoA biosynthesis 0.68173913 0.82312253 0.705019305 kegg kegg NA NA no no no no no dn alpha-Linolenic acid metabolism Pantothenate and CoA biosynthesis 0 0.753952569 0.491891892 kegg kegg NA NA no no no no no dn Arginine and proline metabolism Pantothenate and CoA biosynthesis 0.623478261 0.803359684 0.551608752 kegg kegg NA NA no up no no no dn Arginine biosynthesis Pantothenate and CoA biosynthesis 0.745217391 0.786561265 0.694980695 kegg kegg NA NA no no no no no dn Butanoate metabolism Pantothenate and CoA biosynthesis 0 -0.514822134 0 kegg kegg NA NA no no no no no dn Citrate cycle (TCA cycle) Pantothenate and CoA biosynthesis 0 -0.483201581 0 kegg kegg NA NA no no no no no dn Cysteine and methionine metabolism Pantothenate and CoA biosynthesis 0 -0.495059289 0 kegg kegg NA NA no no no no no dn Ether lipid metabolism Pantothenate and CoA biosynthesis 0 -0.466403162 0 kegg kegg NA NA no no no no no dn Fatty acid biosynthesis Pantothenate and CoA biosynthesis 0.78173913 0.852766798 0.73976834 kegg kegg NA NA no no no no no dn Fatty acid degradation Pantothenate and CoA biosynthesis 0.696521739 0.708498024 0.712741313 kegg kegg NA NA no no no no no dn Fructose and mannose metabolism Pantothenate and CoA biosynthesis 0 0 0.567052767 kegg kegg NA NA no no no no no dn Galactose metabolism Pantothenate and CoA biosynthesis 0 0.663043478 0 kegg kegg NA NA no no no no no dn Glutathione metabolism Pantothenate and CoA biosynthesis -0.575652174 -0.656126482 0 kegg kegg NA NA no no no no no dn "Glycine, serine and threonine metabolism" Pantothenate and CoA biosynthesis -0.635652174 -0.455533597 0 kegg kegg NA NA no up no no no dn Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Pantothenate and CoA biosynthesis 0.580869565 0.577075099 0 kegg kegg NA NA no no no no no dn Glycosaminoglycan biosynthesis - heparan sulfate / heparin Pantothenate and CoA biosynthesis 0 -0.519762846 0 kegg kegg NA NA no no no no no dn Glycosaminoglycan biosynthesis - keratan sulfate Pantothenate and CoA biosynthesis -0.446956522 -0.59486166 -0.445045045 kegg kegg NA NA no no no no no dn Glycosaminoglycan degradation Pantothenate and CoA biosynthesis 0 0.599802372 0 kegg kegg NA NA no no up no no dn Glyoxylate and dicarboxylate metabolism Pantothenate and CoA biosynthesis 0.635652174 0.794466403 0.756499356 kegg kegg NA NA no no no no no dn Histidine metabolism Pantothenate and CoA biosynthesis 0 0.447628458 0.472072072 kegg kegg NA NA no no no no no dn Mannose type O-glycan biosynthesis Pantothenate and CoA biosynthesis 0 0 -0.431145431 kegg kegg NA NA no no no no no dn N-Glycan biosynthesis Pantothenate and CoA biosynthesis 0 -0.785573123 -0.432689833 kegg kegg NA NA no no no no no dn Nicotinate and nicotinamide metabolism Pantothenate and CoA biosynthesis 0.846086957 0.898221344 0.793564994 kegg kegg NA NA no no no no no dn One carbon pool by folate Pantothenate and CoA biosynthesis 0 -0.47826087 0 kegg kegg NA NA no no no no no dn Oxidative phosphorylation Pantothenate and CoA biosynthesis 0 -0.76284585 -0.46975547 kegg kegg NA NA no no no no no dn Pentose and glucuronate interconversions Pantothenate and CoA biosynthesis 0 -0.645256917 0 kegg kegg NA NA no no no no no dn Pentose phosphate pathway Pantothenate and CoA biosynthesis 0.470434783 0.732213439 0.802831403 kegg kegg NA NA no no no no no dn Propanoate metabolism Pantothenate and CoA biosynthesis 0 -0.435770751 0 kegg kegg NA NA no no no no no dn Purine metabolism Pantothenate and CoA biosynthesis -0.511304348 -0.552371542 0 kegg kegg NA NA no no no no no dn Pyrimidine metabolism Pantothenate and CoA biosynthesis 0 -0.4743083 0 kegg kegg NA NA no no no no no dn Pyruvate metabolism Pantothenate and CoA biosynthesis 0 -0.591897233 0 kegg kegg NA NA no no no no no dn Starch and sucrose metabolism Pantothenate and CoA biosynthesis 0.655652174 0.899209486 0.578635779 kegg kegg NA NA no no no no no dn Thiamine metabolism Pantothenate and CoA biosynthesis 0 -0.519762846 0 kegg kegg NA NA no no no no no dn Various types of N-glycan biosynthesis Pantothenate and CoA biosynthesis 0 -0.671936759 0 kegg kegg NA NA no no no no no dn Bacteroides Parabacteroides 0 0.513628491 0 LPS-producing Genus Genus 0.000267 4.19E-05 dn dn up no up up 2-Oxocarboxylic acid metabolism "Parathyroid hormone synthesis, secretion and action" -0.492173913 0 0 kegg kegg NA NA no no no no no no ABC transporters "Parathyroid hormone synthesis, secretion and action" -0.462608696 0 -0.409266409 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes "Parathyroid hormone synthesis, secretion and action" 0.746956522 0.824110672 0.702702703 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" "Parathyroid hormone synthesis, secretion and action" 0 -0.484189723 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion "Parathyroid hormone synthesis, secretion and action" 0.68 0.800395257 0.680823681 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism "Parathyroid hormone synthesis, secretion and action" -0.607826087 -0.671936759 -0.684942085 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism "Parathyroid hormone synthesis, secretion and action" -0.462608696 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis "Parathyroid hormone synthesis, secretion and action" -0.493043478 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway "Parathyroid hormone synthesis, secretion and action" 0 0.558300395 0.431660232 kegg kegg NA NA no no no no no no Apelin signaling pathway "Parathyroid hormone synthesis, secretion and action" 0.487826087 0.657114625 0 kegg kegg NA NA no no no no no no Apoptosis "Parathyroid hormone synthesis, secretion and action" 0 -0.418972332 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism "Parathyroid hormone synthesis, secretion and action" 0 -0.480237154 0 kegg kegg NA NA no up no no no no Arginine biosynthesis "Parathyroid hormone synthesis, secretion and action" -0.424347826 -0.440711462 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism "Parathyroid hormone synthesis, secretion and action" -0.712173913 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids "Parathyroid hormone synthesis, secretion and action" -0.656521739 -0.536561265 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids "Parathyroid hormone synthesis, secretion and action" -0.553043478 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism "Parathyroid hormone synthesis, secretion and action" -0.519130435 0 0 kegg kegg NA NA no no no no no no Butyricimonas "Parathyroid hormone synthesis, secretion and action" 0.462684475 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no Calcium signaling pathway "Parathyroid hormone synthesis, secretion and action" 0.606086957 0.695652174 0.591505792 kegg kegg NA NA no up up no no no cAMP signaling pathway "Parathyroid hormone synthesis, secretion and action" 0.755652174 0 0.610810811 yes kegg kegg NA NA no up up no no no Carbon metabolism "Parathyroid hormone synthesis, secretion and action" -0.608695652 0 -0.429343629 kegg kegg NA NA no no no no no no Cardiac muscle contraction "Parathyroid hormone synthesis, secretion and action" 0.632173913 0.747035573 0 kegg kegg NA NA no no up no no no Cell adhesion molecules "Parathyroid hormone synthesis, secretion and action" -0.454782609 -0.535573123 0 kegg kegg NA NA no no no no no no Cellular senescence "Parathyroid hormone synthesis, secretion and action" 0 -0.448616601 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway "Parathyroid hormone synthesis, secretion and action" 0 -0.463438735 0 kegg kegg NA NA no no no no no no Circadian entrainment "Parathyroid hormone synthesis, secretion and action" 0.447826087 0.514822134 0.658429858 kegg kegg NA NA no up up no no no Circadian rhythm "Parathyroid hormone synthesis, secretion and action" 0.580869565 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades "Parathyroid hormone synthesis, secretion and action" -0.532173913 -0.588932806 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion "Parathyroid hormone synthesis, secretion and action" 0.650434783 0.650197628 0.652252252 kegg kegg NA NA no no up no no no Cytokine-cytokine receptor interaction "Parathyroid hormone synthesis, secretion and action" 0 -0.486166008 0 kegg kegg NA NA no no no no no no Dopaminergic synapse "Parathyroid hormone synthesis, secretion and action" 0.749565217 0.68083004 0.718146718 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 "Parathyroid hormone synthesis, secretion and action" 0 0 -0.434234234 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes "Parathyroid hormone synthesis, secretion and action" -0.597391304 0 -0.50990991 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance "Parathyroid hormone synthesis, secretion and action" 0.406086957 0.646245059 0 kegg kegg NA NA no no no no no no Endocrine resistance "Parathyroid hormone synthesis, secretion and action" 0.553913043 0.45256917 0.534362934 kegg kegg NA NA no no no no no no Endocytosis "Parathyroid hormone synthesis, secretion and action" 0 -0.553359684 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway "Parathyroid hormone synthesis, secretion and action" 0 0 0.426254826 kegg kegg NA NA no no no no no no Ether lipid metabolism "Parathyroid hormone synthesis, secretion and action" 0.585217391 0 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis "Parathyroid hormone synthesis, secretion and action" -0.419130435 -0.527667984 0 kegg kegg NA NA no no no no no no Fatty acid degradation "Parathyroid hormone synthesis, secretion and action" -0.685217391 -0.602766798 -0.471042471 kegg kegg NA NA no no no no no no Fatty acid elongation "Parathyroid hormone synthesis, secretion and action" -0.580869565 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism "Parathyroid hormone synthesis, secretion and action" -0.766086957 -0.638339921 -0.434234234 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway "Parathyroid hormone synthesis, secretion and action" 0 -0.498023715 -0.453024453 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis "Parathyroid hormone synthesis, secretion and action" -0.631304348 -0.633399209 0 kegg kegg NA NA no no no no no no Ferroptosis "Parathyroid hormone synthesis, secretion and action" 0.449565217 0.423913043 0 kegg kegg NA NA no no no no no no FoxO signaling pathway "Parathyroid hormone synthesis, secretion and action" 0 -0.581027668 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism "Parathyroid hormone synthesis, secretion and action" -0.523478261 0 0 kegg kegg NA NA no no no no no no Galactose metabolism "Parathyroid hormone synthesis, secretion and action" -0.689565217 -0.707509881 -0.494723295 kegg kegg NA NA no no no no no no Glucagon signaling pathway "Parathyroid hormone synthesis, secretion and action" 0.584347826 0.711462451 0.623938224 kegg kegg NA NA no no no no no no Glutathione metabolism "Parathyroid hormone synthesis, secretion and action" 0 0.589920949 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism "Parathyroid hormone synthesis, secretion and action" 0 -0.524703557 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis "Parathyroid hormone synthesis, secretion and action" -0.500869565 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate "Parathyroid hormone synthesis, secretion and action" 0 -0.442687747 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation "Parathyroid hormone synthesis, secretion and action" 0 -0.483201581 -0.539253539 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism "Parathyroid hormone synthesis, secretion and action" -0.580869565 -0.442687747 0 kegg kegg NA NA no no no no no no GnRH signaling pathway "Parathyroid hormone synthesis, secretion and action" 0.633043478 0.733201581 0.745945946 kegg kegg NA NA no no no no no no Hematopoietic cell lineage "Parathyroid hormone synthesis, secretion and action" -0.529565217 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway "Parathyroid hormone synthesis, secretion and action" 0 0.529644269 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species "Parathyroid hormone synthesis, secretion and action" 0 -0.552371542 -0.493951094 kegg kegg NA NA no no no no no no Histidine metabolism "Parathyroid hormone synthesis, secretion and action" -0.5 0 -0.53976834 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels "Parathyroid hormone synthesis, secretion and action" 0.574782609 0.693675889 0.624967825 kegg kegg NA NA no no no no no no Insulin secretion "Parathyroid hormone synthesis, secretion and action" 0.553913043 0.723320158 0.666151866 yes kegg kegg NA NA no up up no no no Insulin signaling pathway "Parathyroid hormone synthesis, secretion and action" 0.417391304 0.60770751 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway "Parathyroid hormone synthesis, secretion and action" 0 -0.538537549 0 kegg kegg NA NA no no no no no no Long-term depression "Parathyroid hormone synthesis, secretion and action" 0.627826087 0.491106719 0.532046332 kegg kegg NA NA no no no no no no Longevity regulating pathway "Parathyroid hormone synthesis, secretion and action" 0.444347826 0 0.405920206 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species "Parathyroid hormone synthesis, secretion and action" 0 -0.52173913 0 kegg kegg NA NA no no no no no no Lysosome "Parathyroid hormone synthesis, secretion and action" 0 0 -0.410810811 kegg kegg NA NA no no no no no no MAPK signaling pathway "Parathyroid hormone synthesis, secretion and action" 0 -0.5 0 kegg kegg NA NA no no no no no no Melanogenesis "Parathyroid hormone synthesis, secretion and action" 0.517391304 0.781620553 0.732561133 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 "Parathyroid hormone synthesis, secretion and action" 0 0 -0.450707851 kegg kegg NA NA no no no no no no Mitophagy - animal "Parathyroid hormone synthesis, secretion and action" 0.789565217 0.830039526 0.587129987 kegg kegg NA NA no no no no no no mRNA surveillance pathway "Parathyroid hormone synthesis, secretion and action" 0.657391304 0.57312253 0 kegg kegg NA NA no no no no no no mTOR signaling pathway "Parathyroid hormone synthesis, secretion and action" 0.463478261 0.654150198 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity "Parathyroid hormone synthesis, secretion and action" 0 -0.464426877 0 kegg kegg NA NA no no no no no no Necroptosis "Parathyroid hormone synthesis, secretion and action" 0.546956522 0.554347826 0.437065637 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction "Parathyroid hormone synthesis, secretion and action" 0 -0.635375494 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway "Parathyroid hormone synthesis, secretion and action" 0.488695652 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation "Parathyroid hormone synthesis, secretion and action" -0.540869565 -0.539525692 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway "Parathyroid hormone synthesis, secretion and action" 0 -0.460474308 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism "Parathyroid hormone synthesis, secretion and action" -0.482608696 -0.48715415 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway "Parathyroid hormone synthesis, secretion and action" -0.49826087 -0.490118577 0 kegg kegg NA NA no no no no no no Non-homologous end-joining "Parathyroid hormone synthesis, secretion and action" -0.586956522 0 0 kegg kegg NA NA no no no no no no Olfactory transduction "Parathyroid hormone synthesis, secretion and action" 0 -0.492094862 0 kegg kegg NA NA no no no no no no Oscillospira "Parathyroid hormone synthesis, secretion and action" 0 -0.441699605 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation "Parathyroid hormone synthesis, secretion and action" 0 -0.572134387 0 kegg kegg NA NA no no no no no no Other glycan degradation "Parathyroid hormone synthesis, secretion and action" 0 -0.423913043 -0.45019305 kegg kegg NA NA no no no no no no Ovarian steroidogenesis "Parathyroid hormone synthesis, secretion and action" 0 0.58201581 0.476705277 kegg kegg NA NA no up up no no no Oxidative phosphorylation "Parathyroid hormone synthesis, secretion and action" 0.643478261 0.774703557 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis "Parathyroid hormone synthesis, secretion and action" -0.439130435 -0.64229249 -0.410810811 kegg kegg NA NA no no dn no no no Pentose phosphate pathway "Parathyroid hormone synthesis, secretion and action" 0 -0.539525692 0 kegg kegg NA NA no no no no no no Peroxisome "Parathyroid hormone synthesis, secretion and action" -0.644347826 -0.638339921 0 kegg kegg NA NA no no no no no no Phagosome "Parathyroid hormone synthesis, secretion and action" -0.503478261 -0.505928854 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism "Parathyroid hormone synthesis, secretion and action" -0.48173913 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway "Parathyroid hormone synthesis, secretion and action" 0 -0.416007905 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis "Parathyroid hormone synthesis, secretion and action" -0.466956522 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway "Parathyroid hormone synthesis, secretion and action" 0 -0.464426877 0 kegg kegg NA NA no no no no no no Protein export "Parathyroid hormone synthesis, secretion and action" 0.49826087 0.488142292 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum "Parathyroid hormone synthesis, secretion and action" 0.446956522 0.453557312 0.456370656 kegg kegg NA NA no no no no no no Pyramidobacter "Parathyroid hormone synthesis, secretion and action" 0 0 0.405765075 Genus kegg 0.45 NA no no no no no no Pyrimidine metabolism "Parathyroid hormone synthesis, secretion and action" -0.675652174 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes "Parathyroid hormone synthesis, secretion and action" 0.570434783 0.530632411 0.577863578 kegg kegg NA NA no no no no no no Relaxin signaling pathway "Parathyroid hormone synthesis, secretion and action" 0.731304348 0 0.53976834 kegg kegg NA NA no no no no no no Renin secretion "Parathyroid hormone synthesis, secretion and action" 0 0.675889328 0.658944659 kegg kegg NA NA no no no no no no Renin-angiotensin system "Parathyroid hormone synthesis, secretion and action" 0 -0.532608696 0 kegg kegg NA NA no no no no no no Retinol metabolism "Parathyroid hormone synthesis, secretion and action" -0.519130435 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling "Parathyroid hormone synthesis, secretion and action" 0 0.686758893 0 kegg kegg NA NA no no up no no no Ribosome "Parathyroid hormone synthesis, secretion and action" 0.693043478 0.791501976 0.488030888 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway "Parathyroid hormone synthesis, secretion and action" 0 -0.429841897 0 kegg kegg NA NA no no no no no no RNA degradation "Parathyroid hormone synthesis, secretion and action" 0.573043478 0.514822134 0 kegg kegg NA NA no no no no no no RNA transport "Parathyroid hormone synthesis, secretion and action" 0 0.552371542 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells "Parathyroid hormone synthesis, secretion and action" 0.451304348 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport "Parathyroid hormone synthesis, secretion and action" 0 -0.559288538 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism "Parathyroid hormone synthesis, secretion and action" 0 0 -0.491119691 kegg kegg NA NA no no no no no no Starch and sucrose metabolism "Parathyroid hormone synthesis, secretion and action" -0.451304348 -0.584980237 -0.488288288 kegg kegg NA NA no no no no no no Synaptic vesicle cycle "Parathyroid hormone synthesis, secretion and action" 0 -0.506916996 0 kegg kegg NA NA no up up no no no T cell receptor signaling pathway "Parathyroid hormone synthesis, secretion and action" 0 -0.432806324 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway "Parathyroid hormone synthesis, secretion and action" 0 0.462450593 0 kegg kegg NA NA no no no no no no Thermogenesis "Parathyroid hormone synthesis, secretion and action" 0.688695652 0.770750988 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis "Parathyroid hormone synthesis, secretion and action" 0.474782609 0.745059289 0.501158301 kegg kegg NA NA no no no no no no TNF signaling pathway "Parathyroid hormone synthesis, secretion and action" 0.453913043 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism "Parathyroid hormone synthesis, secretion and action" -0.610434783 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism "Parathyroid hormone synthesis, secretion and action" -0.469565217 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis "Parathyroid hormone synthesis, secretion and action" -0.493043478 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis "Parathyroid hormone synthesis, secretion and action" 0.777391304 0.805335968 0.584813385 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" "Parathyroid hormone synthesis, secretion and action" -0.473043478 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction "Parathyroid hormone synthesis, secretion and action" 0.756521739 0.675889328 0.676705277 kegg kegg NA NA no no no no no no Wnt signaling pathway "Parathyroid hormone synthesis, secretion and action" 0.503478261 0.416996047 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Parkinson disease -0.473913043 0 0 kegg kegg NA NA no no no no no no ABC transporters Parkinson disease -0.512173913 0 0 kegg kegg NA NA no up up no no no Adherens junction Parkinson disease 0 0.563241107 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Parkinson disease 0.465217391 0 0.420849421 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Parkinson disease 0.782608696 0.809288538 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Parkinson disease 0 -0.751976285 -0.530501931 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Parkinson disease -0.576521739 -0.649209486 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Parkinson disease 0.71826087 0.770750988 0.412097812 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Parkinson disease 0 0 -0.740797941 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Parkinson disease -0.647826087 -0.709486166 -0.487001287 kegg kegg NA NA no no no no no no Alzheimer disease Parkinson disease 0.826086957 0.966403162 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Parkinson disease -0.585217391 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Parkinson disease -0.599130435 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Parkinson disease 0 0.51284585 0.519433719 kegg kegg NA NA no no no no no no Apelin signaling pathway Parkinson disease 0.437391304 0.717391304 0 kegg kegg NA NA no no no no no no Apoptosis Parkinson disease -0.469565217 -0.549407115 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Parkinson disease 0 -0.445652174 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Parkinson disease -0.470434783 -0.718379447 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Parkinson disease -0.6 -0.587944664 0 kegg kegg NA NA no no no no no no Autophagy - animal Parkinson disease 0 -0.627470356 -0.597168597 kegg kegg NA NA no no no no no no Axon guidance Parkinson disease 0.44173913 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Parkinson disease 0 -0.592885375 0 kegg kegg NA NA no no no no no no Bacteroides Parkinson disease -0.420869565 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no beta-Alanine metabolism Parkinson disease -0.713913043 0 0 kegg kegg NA NA no no no no no no Bile secretion Parkinson disease 0.61826087 0.554347826 0.556756757 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Parkinson disease -0.753043478 -0.595849802 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Parkinson disease 0 0.416996047 0.420592021 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Parkinson disease -0.592173913 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Parkinson disease -0.520869565 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Parkinson disease 0 -0.548418972 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Parkinson disease 0.71826087 0.723320158 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Parkinson disease 0.756521739 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Parkinson disease 0 -0.470355731 -0.668725869 kegg kegg NA NA no no no no no no Carbon metabolism Parkinson disease -0.671304348 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Parkinson disease 0.786086957 0.924901186 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Parkinson disease -0.493043478 -0.459486166 0 kegg kegg NA NA no no no no no no Cellular senescence Parkinson disease 0 -0.416996047 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Parkinson disease 0 -0.614624506 -0.445045045 kegg kegg NA NA no no no no no no Chemokine signaling pathway Parkinson disease 0 -0.416996047 0 kegg kegg NA NA no no no no no no Cholesterol metabolism Parkinson disease 0 0 -0.411840412 yes kegg kegg NA NA no no up no no no Cholinergic synapse Parkinson disease 0 -0.457509881 -0.499099099 kegg kegg NA NA no no no no no no Circadian entrainment Parkinson disease 0.446956522 0.523715415 0.555727156 kegg kegg NA NA no up up no no no Circadian rhythm Parkinson disease 0.617391304 0 0 kegg kegg NA NA no no no no no no Collinsella Parkinson disease 0 0 0.423020121 Genus kegg 0.128 NA no no no no no no Complement and coagulation cascades Parkinson disease -0.584347826 -0.62055336 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Parkinson disease 0.623478261 0.480237154 0.472586873 kegg kegg NA NA no no up no no no Cushing syndrome Parkinson disease 0.608695652 0.501976285 0 kegg kegg NA NA no no up no no no Cytokine-cytokine receptor interaction Parkinson disease 0 -0.46541502 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Parkinson disease 0.742608696 0.674901186 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Parkinson disease 0 0.423913043 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Parkinson disease -0.533043478 0.463438735 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Parkinson disease 0 0.652173913 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Parkinson disease 0.648695652 0.807312253 0.571428571 kegg kegg NA NA no no no no no no Endocrine resistance Parkinson disease 0.5 0 0 kegg kegg NA NA no no no no no no Endocytosis Parkinson disease -0.419130435 -0.481225296 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Parkinson disease 0 -0.459486166 -0.588416988 kegg kegg NA NA no no no no no no Ether lipid metabolism Parkinson disease 0.774782609 0.41798419 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Parkinson disease -0.612173913 -0.562252964 -0.475160875 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Parkinson disease -0.595652174 -0.730237154 0 kegg kegg NA NA no no no no no no Fatty acid degradation Parkinson disease -0.847826087 -0.794466403 0 kegg kegg NA NA no no no no no no Fatty acid elongation Parkinson disease -0.590434783 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Parkinson disease -0.912173913 -0.779644269 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Parkinson disease 0 -0.66798419 -0.590733591 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Parkinson disease -0.72173913 -0.633399209 0 kegg kegg NA NA no no no no no no Ferroptosis Parkinson disease 0.46173913 0 0.624967825 kegg kegg NA NA no no no no no no Focal adhesion Parkinson disease 0 0.43083004 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Parkinson disease 0 -0.742094862 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Parkinson disease -0.635652174 -0.516798419 0 kegg kegg NA NA no no no no no no GABAergic synapse Parkinson disease -0.468695652 -0.556324111 0 kegg kegg NA NA no up up no no no Galactose metabolism Parkinson disease -0.766956522 -0.785573123 -0.465122265 kegg kegg NA NA no no no no no no Gastric acid secretion Parkinson disease 0 0.656126482 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Parkinson disease 0.524347826 0.761857708 0 kegg kegg NA NA no no no no no no Glutathione metabolism Parkinson disease 0 0.708498024 0.558043758 kegg kegg NA NA no no no no no no Glycerolipid metabolism Parkinson disease 0 -0.62055336 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Parkinson disease 0 0.464426877 0.407207207 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Parkinson disease -0.612173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Parkinson disease 0 -0.685770751 -0.442985843 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Parkinson disease 0.587826087 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Parkinson disease 0 -0.459486166 -0.56010296 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Parkinson disease 0.424347826 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Parkinson disease -0.713043478 -0.596837945 0 kegg kegg NA NA no no no no no no GnRH secretion Parkinson disease 0 0 -0.433976834 kegg kegg NA NA no up up no no no GnRH signaling pathway Parkinson disease 0.603478261 0.546442688 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Parkinson disease -0.428695652 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Parkinson disease 0 0.62055336 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Parkinson disease 0 0.533596838 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Parkinson disease 0 -0.717391304 -0.632947233 kegg kegg NA NA no no no no no no Histidine metabolism Parkinson disease -0.523478261 0 -0.432175032 kegg kegg NA NA no no no no no no IL-17 signaling pathway Parkinson disease 0 -0.495059289 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Parkinson disease 0.63826087 0.764822134 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Parkinson disease -0.431304348 -0.485177866 0 kegg kegg NA NA no no no no no no Insulin resistance Parkinson disease 0 -0.48715415 0 kegg kegg NA NA no no no no no no Insulin secretion Parkinson disease 0.571304348 0.583003953 0.406177606 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Parkinson disease 0 0.661067194 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Parkinson disease -0.445217391 -0.681818182 0 kegg kegg NA NA no no no no no no Long-term depression Parkinson disease 0.671304348 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Parkinson disease 0.452173913 0 0.508622909 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Parkinson disease 0.533043478 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Parkinson disease 0 -0.694664032 -0.581467181 kegg kegg NA NA no no no no no no Melanogenesis Parkinson disease 0.60173913 0.820158103 0.480823681 kegg kegg NA NA no no no no no no Mineral absorption Parkinson disease 0.725217391 0.673913043 0.764221364 kegg kegg NA NA no no no no no no Mitophagy - animal Parkinson disease 0.882608696 0.916996047 0.83037323 kegg kegg NA NA no no no no no no mRNA surveillance pathway Parkinson disease 0.72173913 0.592885375 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Parkinson disease 0.414782609 0.656126482 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Parkinson disease 0 -0.473320158 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Parkinson disease 0 0.445652174 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Parkinson disease 0 -0.418972332 0 kegg kegg NA NA no no no no no no Necroptosis Parkinson disease 0.583478261 0.456521739 0.674903475 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Parkinson disease 0 -0.538537549 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Parkinson disease 0.483478261 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Parkinson disease -0.572173913 -0.518774704 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Parkinson disease -0.430434783 -0.637351779 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Parkinson disease -0.569565217 -0.669960474 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Parkinson disease -0.417391304 -0.485177866 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Parkinson disease -0.613913043 -0.671936759 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Parkinson disease 0.853043478 0.949604743 0.599485199 kegg kegg NA NA no no no no no no Non-homologous end-joining Parkinson disease -0.670434783 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Parkinson disease 0 0 -0.403861004 kegg kegg NA NA no no no no no no Olfactory transduction Parkinson disease 0 -0.556324111 0 kegg kegg NA NA no no no no no no Oscillospira Parkinson disease 0 -0.493083004 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Parkinson disease -0.460869565 -0.688735178 0 kegg kegg NA NA no no no no no no Other glycan degradation Parkinson disease 0 -0.527667984 -0.536164736 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Parkinson disease 0.426956522 0.437747036 0.49034749 kegg kegg NA NA no up up no no no Oxidative phosphorylation Parkinson disease 0.808695652 0.955533597 0.434749035 kegg kegg NA NA no no no no no no Pancreatic secretion Parkinson disease 0.773043478 0.692687747 0.461261261 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Parkinson disease -0.570434783 -0.736166008 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Parkinson disease 0.860869565 0.833003953 0.623938224 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Parkinson disease 0 0.419960474 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Parkinson disease -0.436521739 -0.572134387 0 kegg kegg NA NA no no no no no no Peroxisome Parkinson disease -0.739130435 -0.656126482 0 kegg kegg NA NA no no no no no no Phagosome Parkinson disease -0.514782609 -0.470355731 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Parkinson disease 0.430434783 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Parkinson disease 0 -0.469367589 0 kegg kegg NA NA no up up no no no Phototransduction Parkinson disease 0 0.472332016 0 kegg kegg NA NA no no no no no no Platelet activation Parkinson disease 0 0.469367589 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Parkinson disease 0 0.492094862 0.482368082 kegg kegg NA NA no no no no no no PPAR signaling pathway Parkinson disease 0 -0.538537549 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Parkinson disease -0.475652174 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Parkinson disease 0 -0.611660079 -0.416473616 kegg kegg NA NA no no no no no no Proteasome Parkinson disease 0 0.438735178 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Parkinson disease -0.793043478 -0.848814229 -0.663063063 yes kegg kegg NA NA no up up no no no Protein export Parkinson disease 0.529565217 0.700592885 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Parkinson disease 0.413043478 0.567193676 0.610553411 kegg kegg NA NA no no no no no no Purine metabolism Parkinson disease 0 0.5 0.550579151 kegg kegg NA NA no no no no no no Pyrimidine metabolism Parkinson disease -0.697391304 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Parkinson disease 0 0.510869565 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Parkinson disease 0.52 0.425889328 0.440669241 kegg kegg NA NA no no no no no no Relaxin signaling pathway Parkinson disease 0.691304348 0 0 kegg kegg NA NA no no no no no no Renin secretion Parkinson disease 0.484347826 0.789525692 0.579150579 kegg kegg NA NA no no no no no no Renin-angiotensin system Parkinson disease 0 -0.610671937 -0.447876448 kegg kegg NA NA no no no no no no Retinol metabolism Parkinson disease -0.614782609 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Parkinson disease 0.55826087 0.882411067 0 kegg kegg NA NA no no up no no no Ribosome Parkinson disease 0.826086957 0.863636364 0.588159588 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Parkinson disease 0 -0.576086957 0 kegg kegg NA NA no no no no no no RNA degradation Parkinson disease 0.677391304 0.567193676 0 kegg kegg NA NA no no no no no no RNA polymerase Parkinson disease 0 0.508893281 0 kegg kegg NA NA no no no no no no RNA transport Parkinson disease 0 0.526679842 0 kegg kegg NA NA no no no no no no Ruminococcus Parkinson disease 0 0.42446886 0 Genus kegg 0.0679 NA no no dn no no no Signaling pathways regulating pluripotency of stem cells Parkinson disease 0.428695652 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Parkinson disease 0 -0.677865613 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Parkinson disease 0 0 -0.565508366 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Parkinson disease 0 0 -0.587902188 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Parkinson disease -0.580869565 -0.766798419 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Parkinson disease 0 -0.528656126 0 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Parkinson disease 0 -0.473320158 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Parkinson disease 0.644347826 0.57312253 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Parkinson disease 0 -0.451581028 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Parkinson disease 0 -0.448616601 0 kegg kegg NA NA no no no no no no Thermogenesis Parkinson disease 0.855652174 0.93972332 0.512483912 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Parkinson disease 0 0.549407115 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Parkinson disease 0.545217391 0.662055336 0.58970399 kegg kegg NA NA no no no no no no Tight junction Parkinson disease 0 0.479249012 0 kegg kegg NA NA no no no no no no TNF signaling pathway Parkinson disease 0 -0.496047431 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Parkinson disease 0 -0.562252964 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Parkinson disease -0.582608696 0 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Parkinson disease 0 -0.589920949 -0.64015444 kegg kegg NA NA no no no no no no Tyrosine metabolism Parkinson disease -0.409565217 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Parkinson disease -0.428695652 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Parkinson disease 0.883478261 0.919960474 0.841956242 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Parkinson disease -0.466956522 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Parkinson disease 0.897391304 0.840909091 0.508880309 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Parkinson disease 0.67826087 0.759881423 0.623938224 kegg kegg NA NA no no no no no no VEGF signaling pathway Parkinson disease 0 -0.440711462 -0.515830116 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Parkinson disease 0.469565217 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Parkinson disease 0.666956522 0.5256917 0 kegg kegg NA NA no no no no no no ABC transporters Pathogenic Escherichia coli infection 0 0 -0.409009009 kegg kegg NA NA no up up no no no Adherens junction Pathogenic Escherichia coli infection 0.473043478 0 0.646074646 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Pathogenic Escherichia coli infection 0 -0.519762846 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Pathogenic Escherichia coli infection 0 0.434782609 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Pathogenic Escherichia coli infection -0.57826087 -0.725296443 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Pathogenic Escherichia coli infection 0.572173913 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Pathogenic Escherichia coli infection 0 -0.419960474 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Pathogenic Escherichia coli infection 0 0 -0.504504505 kegg kegg NA NA no no no no no no Amphetamine addiction Pathogenic Escherichia coli infection -0.523478261 -0.788537549 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Pathogenic Escherichia coli infection 0 -0.62055336 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Pathogenic Escherichia coli infection 0 -0.499011858 0 kegg kegg NA NA no no no no no no Antifolate resistance Pathogenic Escherichia coli infection 0 -0.462450593 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Pathogenic Escherichia coli infection 0.479130435 0.490118577 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Pathogenic Escherichia coli infection -0.500869565 0 0 kegg kegg NA NA no no no no no no Apoptosis Pathogenic Escherichia coli infection 0.817391304 0.685770751 0.764736165 kegg kegg NA NA no no no no no no Apoptosis - multiple species Pathogenic Escherichia coli infection -0.516521739 -0.492094862 -0.555727156 kegg kegg NA NA no no no no no no Arginine and proline metabolism Pathogenic Escherichia coli infection 0.457391304 0.473320158 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Pathogenic Escherichia coli infection 0 0.467391304 0 kegg kegg NA NA no no no no no no Autophagy - other Pathogenic Escherichia coli infection 0 0 -0.563191763 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Pathogenic Escherichia coli infection 0 0.559288538 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Pathogenic Escherichia coli infection 0.62 0 0.702960103 kegg kegg NA NA no no no no no no Basal transcription factors Pathogenic Escherichia coli infection -0.546956522 -0.774703557 -0.73951094 kegg kegg NA NA no no no no no no Base excision repair Pathogenic Escherichia coli infection -0.48 -0.679841897 -0.593822394 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Pathogenic Escherichia coli infection 0.587826087 0.821146245 0.685199485 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Pathogenic Escherichia coli infection 0 -0.730237154 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Pathogenic Escherichia coli infection 0 0.537549407 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Pathogenic Escherichia coli infection -0.522608696 0 0 kegg kegg NA NA no up up no no no Carbon metabolism Pathogenic Escherichia coli infection 0.491304348 0.645256917 0.649163449 kegg kegg NA NA no no no no no no Cell adhesion molecules Pathogenic Escherichia coli infection 0.513913043 0.828063241 0.592535393 kegg kegg NA NA no no no no no no Cell cycle Pathogenic Escherichia coli infection -0.579130435 -0.769762846 -0.662548263 kegg kegg NA NA no no no no no no Cellular senescence Pathogenic Escherichia coli infection 0.475652174 0.725296443 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Pathogenic Escherichia coli infection 0 0.778656126 0.401544402 kegg kegg NA NA no no no no no no Chemokine signaling pathway Pathogenic Escherichia coli infection 0.445217391 0.683794466 0.638095238 kegg kegg NA NA no no no no no no Cholesterol metabolism Pathogenic Escherichia coli infection 0 0.756916996 0 yes kegg kegg NA NA no no up no no no Circadian rhythm Pathogenic Escherichia coli infection -0.497391304 -0.773715415 -0.703474903 kegg kegg NA NA no no no no no no Cocaine addiction Pathogenic Escherichia coli infection 0 -0.56027668 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Pathogenic Escherichia coli infection 0.582608696 0.699604743 0.714543115 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Pathogenic Escherichia coli infection -0.406086957 -0.727272727 0 kegg kegg NA NA no no up no no no Cushing syndrome Pathogenic Escherichia coli infection -0.50173913 -0.825098814 0 kegg kegg NA NA no no up no no no Cytokine-cytokine receptor interaction Pathogenic Escherichia coli infection 0 0.416007905 0.445302445 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Pathogenic Escherichia coli infection 0.476521739 0 0 kegg kegg NA NA no no no no no no DNA replication Pathogenic Escherichia coli infection 0 -0.554347826 -0.534362934 kegg kegg NA NA no no no no no no Dopaminergic synapse Pathogenic Escherichia coli infection 0 -0.501976285 0 kegg kegg NA NA no up no no no no EGFR tyrosine kinase inhibitor resistance Pathogenic Escherichia coli infection -0.435652174 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Pathogenic Escherichia coli infection 0 -0.562252964 0 kegg kegg NA NA no no no no no no Endocrine resistance Pathogenic Escherichia coli infection -0.476521739 -0.62055336 0 kegg kegg NA NA no no no no no no Endocytosis Pathogenic Escherichia coli infection 0.566956522 0.827075099 0.482368082 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection 0.655652174 0.766798419 0.555212355 kegg kegg NA NA no no no no no no Estrogen signaling pathway Pathogenic Escherichia coli infection 0 -0.494071146 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Pathogenic Escherichia coli infection 0 -0.743083004 -0.471557272 kegg kegg NA NA no no no no no no Eubacterium Pathogenic Escherichia coli infection 0 0 -0.47284869 Genus kegg 0.0692 NA no no no no no no Fanconi anemia pathway Pathogenic Escherichia coli infection 0 -0.693675889 -0.67001287 kegg kegg NA NA no no no no no no Fat digestion and absorption Pathogenic Escherichia coli infection 0.453913043 0.553359684 0.503732304 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Pathogenic Escherichia coli infection 0 0.485177866 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Pathogenic Escherichia coli infection 0 0.60770751 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Pathogenic Escherichia coli infection 0.656521739 0.765810277 0.564736165 kegg kegg NA NA no no no no no no Focal adhesion Pathogenic Escherichia coli infection 0.453913043 0 0.518918919 kegg kegg NA NA no up up no no no Galactose metabolism Pathogenic Escherichia coli infection 0.470434783 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Pathogenic Escherichia coli infection 0 0 0.543629344 kegg kegg NA NA no no no no no no Glucagon signaling pathway Pathogenic Escherichia coli infection -0.675652174 -0.761857708 -0.542342342 kegg kegg NA NA no no no no no no Glutathione metabolism Pathogenic Escherichia coli infection 0 -0.518774704 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Pathogenic Escherichia coli infection -0.453913043 -0.492094862 -0.578893179 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Pathogenic Escherichia coli infection 0 -0.638339921 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Pathogenic Escherichia coli infection 0.427826087 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Pathogenic Escherichia coli infection -0.423478261 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Pathogenic Escherichia coli infection 0.482608696 0.531620553 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Pathogenic Escherichia coli infection 0 -0.445652174 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Pathogenic Escherichia coli infection -0.405217391 -0.704545455 -0.438352638 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Pathogenic Escherichia coli infection 0 0.509881423 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Pathogenic Escherichia coli infection -0.534782609 -0.635375494 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Pathogenic Escherichia coli infection -0.510434783 -0.590909091 -0.562162162 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Pathogenic Escherichia coli infection -0.44 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Pathogenic Escherichia coli infection 0 0 0.470527671 kegg kegg NA NA no no no no no no Homologous recombination Pathogenic Escherichia coli infection 0 -0.623517787 -0.703732304 kegg kegg NA NA no no no no no no Huntington disease Pathogenic Escherichia coli infection 0 -0.435770751 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Pathogenic Escherichia coli infection 0.519130435 0.738142292 0.474646075 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Pathogenic Escherichia coli infection -0.473043478 -0.586956522 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Pathogenic Escherichia coli infection 0 0 -0.447104247 kegg kegg NA NA no no no no no no Insulin resistance Pathogenic Escherichia coli infection 0 0 -0.469240669 kegg kegg NA NA no no no no no no Insulin secretion Pathogenic Escherichia coli infection -0.446086957 -0.693675889 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Pathogenic Escherichia coli infection -0.524347826 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Pathogenic Escherichia coli infection 0.626086957 0.570158103 0.88005148 kegg kegg NA NA no no no no no no Long-term potentiation Pathogenic Escherichia coli infection -0.506956522 0 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Pathogenic Escherichia coli infection -0.449565217 -0.450592885 0 kegg kegg NA NA no no no no no no Lysine degradation Pathogenic Escherichia coli infection 0 -0.623517787 -0.611840412 kegg kegg NA NA no no no no no no Lysosome Pathogenic Escherichia coli infection 0.53826087 0.812252964 0.583011583 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Pathogenic Escherichia coli infection 0 -0.493083004 -0.560617761 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Pathogenic Escherichia coli infection 0 -0.539525692 0 kegg kegg NA NA no up no no no no Melanogenesis Pathogenic Escherichia coli infection 0 -0.551383399 0 kegg kegg NA NA no no no no no no Mismatch repair Pathogenic Escherichia coli infection 0 -0.492094862 0 kegg kegg NA NA no no no no no no Mitophagy - animal Pathogenic Escherichia coli infection 0 -0.446640316 0 kegg kegg NA NA no no no no no no Morphine addiction Pathogenic Escherichia coli infection 0 -0.493083004 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Pathogenic Escherichia coli infection -0.516521739 -0.711462451 -0.642471042 kegg kegg NA NA no no no no no no mTOR signaling pathway Pathogenic Escherichia coli infection -0.468695652 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Pathogenic Escherichia coli infection 0 0 -0.459202059 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Pathogenic Escherichia coli infection -0.639130435 -0.544466403 -0.466151866 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Pathogenic Escherichia coli infection 0.642608696 0.806324111 0.445302445 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Pathogenic Escherichia coli infection 0.615652174 0.75 0.612612613 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Pathogenic Escherichia coli infection 0 0.477272727 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Pathogenic Escherichia coli infection 0.777391304 0.774703557 0.813127413 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Pathogenic Escherichia coli infection 0.407826087 0.509881423 0 kegg kegg NA NA no no no no no no Nicotine addiction Pathogenic Escherichia coli infection 0 -0.419960474 0 kegg kegg NA NA no up up no no no NOD-like receptor signaling pathway Pathogenic Escherichia coli infection 0.491304348 0.515810277 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Pathogenic Escherichia coli infection 0 -0.644268775 -0.527413127 kegg kegg NA NA no no no no no no Odoribacter Pathogenic Escherichia coli infection 0 0.484399702 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Olfactory transduction Pathogenic Escherichia coli infection 0 0.67687747 0.521235521 kegg kegg NA NA no no no no no no One carbon pool by folate Pathogenic Escherichia coli infection 0 -0.640316206 -0.515057915 kegg kegg NA NA no no no no no no Oocyte meiosis Pathogenic Escherichia coli infection -0.431304348 0 -0.429086229 kegg kegg NA NA no no no no no no Osteoclast differentiation Pathogenic Escherichia coli infection 0.707826087 0.701581028 0.522007722 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Pathogenic Escherichia coli infection -0.572173913 -0.748023715 -0.737194337 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Pathogenic Escherichia coli infection 0 -0.431818182 0 kegg kegg NA NA no up up no no no Oxytocin signaling pathway Pathogenic Escherichia coli infection 0.460869565 0 0.690862291 kegg kegg NA NA no no no no no no p53 signaling pathway Pathogenic Escherichia coli infection -0.620869565 -0.610671937 -0.849420849 kegg kegg NA NA no no no no no no Pancreatic secretion Pathogenic Escherichia coli infection 0 -0.428853755 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Pathogenic Escherichia coli infection 0.462608696 0.429841897 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Pathogenic Escherichia coli infection 0 -0.421936759 0 kegg kegg NA NA no no no no no no Parkinson disease Pathogenic Escherichia coli infection -0.406086957 -0.435770751 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection -0.42173913 -0.469367589 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Pathogenic Escherichia coli infection 0 -0.427865613 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Pathogenic Escherichia coli infection 0.753043478 0.850790514 0.55032175 kegg kegg NA NA no no no no no no Phagosome Pathogenic Escherichia coli infection 0.626086957 0.916007905 0.78970399 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Pathogenic Escherichia coli infection -0.652173913 -0.583003953 -0.645559846 kegg kegg NA NA no no no no no no Platelet activation Pathogenic Escherichia coli infection 0 0 0.724581725 kegg kegg NA NA no no no no no no Platinum drug resistance Pathogenic Escherichia coli infection -0.519130435 -0.542490119 -0.610810811 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Pathogenic Escherichia coli infection 0 -0.590909091 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Pathogenic Escherichia coli infection 0 0.645256917 0.504504505 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Pathogenic Escherichia coli infection 0 -0.437747036 -0.454826255 kegg kegg NA NA no no no no no no Prolactin signaling pathway Pathogenic Escherichia coli infection 0 0.444664032 0 kegg kegg NA NA no no no no no no Protein export Pathogenic Escherichia coli infection -0.64173913 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Pathogenic Escherichia coli infection -0.515652174 -0.631422925 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Pathogenic Escherichia coli infection 0 -0.491106719 0 kegg kegg NA NA no no no no no no Purine metabolism Pathogenic Escherichia coli infection -0.409565217 -0.644268775 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Pathogenic Escherichia coli infection 0 -0.513833992 -0.45997426 kegg kegg NA NA no no no no no no Rap1 signaling pathway Pathogenic Escherichia coli infection 0.53826087 0 0.795366795 kegg kegg NA NA no no no no no no Ras signaling pathway Pathogenic Escherichia coli infection 0 0 -0.494465894 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Pathogenic Escherichia coli infection 0.530434783 0 0.468211068 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Pathogenic Escherichia coli infection 0 -0.448616601 0 kegg kegg NA NA no no no no no no Renin secretion Pathogenic Escherichia coli infection 0 -0.502964427 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Pathogenic Escherichia coli infection 0.453913043 0.746047431 0.420849421 kegg kegg NA NA no no no no no no Ribosome Pathogenic Escherichia coli infection -0.588695652 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Pathogenic Escherichia coli infection -0.630434783 -0.721343874 -0.696525097 kegg kegg NA NA no no no no no no RNA degradation Pathogenic Escherichia coli infection -0.566956522 -0.581027668 -0.588416988 kegg kegg NA NA no no no no no no RNA polymerase Pathogenic Escherichia coli infection -0.694782609 -0.751976285 -0.533333333 kegg kegg NA NA no no no no no no Selenocompound metabolism Pathogenic Escherichia coli infection -0.409565217 -0.625494071 -0.655341055 kegg kegg NA NA no no no no no no Serotonergic synapse Pathogenic Escherichia coli infection 0 0 0.449163449 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Pathogenic Escherichia coli infection -0.445217391 -0.457509881 -0.54002574 kegg kegg NA NA no no no no no no Sphingolipid metabolism Pathogenic Escherichia coli infection 0.482608696 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Pathogenic Escherichia coli infection 0 0.651185771 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Pathogenic Escherichia coli infection -0.442608696 -0.561264822 -0.45019305 kegg kegg NA NA no no no no no no Spliceosome Pathogenic Escherichia coli infection -0.484347826 -0.566205534 -0.692149292 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Pathogenic Escherichia coli infection 0.643478261 0.422924901 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Pathogenic Escherichia coli infection -0.580869565 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Pathogenic Escherichia coli infection 0.42 0.746047431 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Pathogenic Escherichia coli infection 0 -0.570158103 -0.418275418 kegg kegg NA NA no no no no no no Taste transduction Pathogenic Escherichia coli infection 0 -0.598814229 -0.466924067 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Pathogenic Escherichia coli infection 0 0 -0.44041184 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Pathogenic Escherichia coli infection -0.436521739 -0.506916996 -0.510682111 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Pathogenic Escherichia coli infection -0.473913043 0 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Pathogenic Escherichia coli infection 0 0.420948617 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Pathogenic Escherichia coli infection 0 0.414031621 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Pathogenic Escherichia coli infection -0.514782609 -0.579051383 0 kegg kegg NA NA no no no no no no Tight junction Pathogenic Escherichia coli infection 0.468695652 0 0.619305019 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Pathogenic Escherichia coli infection 0 0.58201581 0.457657658 yes kegg kegg NA NA no no no no no no Type I diabetes mellitus Pathogenic Escherichia coli infection 0 0.770750988 0.471814672 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Pathogenic Escherichia coli infection 0 -0.438735178 -0.426769627 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Pathogenic Escherichia coli infection -0.452173913 -0.585968379 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Pathogenic Escherichia coli infection -0.491304348 -0.460474308 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Pathogenic Escherichia coli infection 0 -0.51284585 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Pathogenic Escherichia coli infection 0 0 0.673359073 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Pathogenic Escherichia coli infection 0 0.443675889 0.453281853 kegg kegg NA NA no no no no no no Wnt signaling pathway Pathogenic Escherichia coli infection 0 -0.571146245 -0.487001287 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Pathways in cancer -0.736521739 -0.42687747 -0.447361647 kegg kegg NA NA no no no no no no ABC transporters Pathways in cancer 0 0.540513834 0 kegg kegg NA NA no up up no no no Adherens junction Pathways in cancer -0.426086957 -0.59486166 -0.412355212 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Pathways in cancer 0 0.477272727 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Pathways in cancer 0.50173913 0 0 kegg kegg NA NA no no up no no no African trypanosomiasis Pathways in cancer 0.452173913 0.43972332 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Pathways in cancer 0 0.622529644 0.477734878 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Pathways in cancer 0 0.470355731 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Pathways in cancer 0.444347826 0 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Pathways in cancer 0.536521739 0.448616601 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Pathways in cancer -0.64 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Pathways in cancer 0.633913043 -0.459486166 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Pathways in cancer -0.542608696 0 0 kegg kegg NA NA no no no no no no Amoebiasis Pathways in cancer 0 0.527667984 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Pathways in cancer 0.531304348 -0.455533597 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Pathways in cancer 0 -0.43083004 -0.424195624 kegg kegg NA NA no no no no no no Apelin signaling pathway Pathways in cancer 0 -0.526679842 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Pathways in cancer 0 0.48715415 0.454568855 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Pathways in cancer -0.536521739 0 -0.463063063 kegg kegg NA NA no no no no no no Arginine and proline metabolism Pathways in cancer 0 0.455533597 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Pathways in cancer 0 0.431818182 0 kegg kegg NA NA no no no no no no Autophagy - animal Pathways in cancer 0.56 0.691699605 0 kegg kegg NA NA no no no no no no Autophagy - other Pathways in cancer 0.606086957 0.494071146 0.551608752 kegg kegg NA NA no no no no no no Axon guidance Pathways in cancer 0.510434783 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Pathways in cancer 0 0.561264822 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Pathways in cancer -0.572173913 -0.643280632 -0.511711712 kegg kegg NA NA no no no no no no Bacteroides Pathways in cancer 0 -0.479249012 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Pathways in cancer 0.423478261 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Pathways in cancer -0.726956522 -0.561264822 -0.475675676 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Pathways in cancer -0.73826087 0 -0.467696268 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Pathways in cancer -0.46173913 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Pathways in cancer -0.627826087 -0.580039526 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Pathways in cancer 0.497391304 0.506916996 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Pathways in cancer 0.59826087 0 0.480823681 kegg kegg NA NA no up up no no no cAMP signaling pathway Pathways in cancer 0.68 0.442687747 0.449163449 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Pathways in cancer 0.486956522 0.673913043 0 kegg kegg NA NA no no no no no no Carbon metabolism Pathways in cancer -0.811304348 -0.587944664 -0.633462033 kegg kegg NA NA no no no no no no Cardiac muscle contraction Pathways in cancer 0.606956522 0 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Pathways in cancer -0.570434783 0 -0.435778636 kegg kegg NA NA no no no no no no Cell cycle Pathways in cancer 0 0 0.410553411 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Pathways in cancer 0.476521739 0 0 kegg kegg NA NA no no no no no no Chagas disease Pathways in cancer 0 0.602766798 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Pathways in cancer 0 0.489130435 0 kegg kegg NA NA no no no no no no Cholinergic synapse Pathways in cancer 0.566086957 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Pathways in cancer 0.817391304 0 0.498584299 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Pathways in cancer -0.475652174 -0.666996047 0 kegg kegg NA NA no no no no no no Clostridium Pathways in cancer 0 -0.626565366 0 Genus kegg 0.925 NA no no no no no no Complement and coagulation cascades Pathways in cancer -0.453043478 0 -0.428828829 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Pathways in cancer 0 -0.524703557 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Pathways in cancer 0 0 0.445559846 kegg kegg NA NA no no up no no no Cushing syndrome Pathways in cancer 0 0 0.658944659 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Pathways in cancer 0 -0.58201581 0 kegg kegg NA NA no no no no no no DNA replication Pathways in cancer 0 -0.433794466 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Pathways in cancer 0.487826087 0 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Pathways in cancer 0 -0.662055336 -0.549034749 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Pathways in cancer -0.70173913 -0.720355731 0 kegg kegg NA NA no no no no no no Endocrine resistance Pathways in cancer 0 0 0.47027027 kegg kegg NA NA no no no no no no Endocytosis Pathways in cancer -0.431304348 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Pathways in cancer 0.597391304 0.708498024 0.453796654 kegg kegg NA NA no no no no no no Estrogen signaling pathway Pathways in cancer 0 -0.475296443 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Pathways in cancer 0.410434783 0 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Pathways in cancer 0 0 -0.441698842 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Pathways in cancer 0 0.471343874 0 kegg kegg NA NA no no no no no no Fatty acid elongation Pathways in cancer -0.637391304 -0.555335968 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Pathways in cancer -0.412173913 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Pathways in cancer 0.445217391 0.469367589 0 kegg kegg NA NA no no no no no no Focal adhesion Pathways in cancer -0.437391304 -0.638339921 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Pathways in cancer 0.488695652 0.711462451 0.566280566 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Pathways in cancer -0.654782609 0 -0.433976834 kegg kegg NA NA no no no no no no GABAergic synapse Pathways in cancer 0 0.48715415 0 kegg kegg NA NA no up up no no no Galactose metabolism Pathways in cancer -0.593913043 0 0 kegg kegg NA NA no no no no no no Gap junction Pathways in cancer 0 0.462450593 0 kegg kegg NA NA no no no no no no Gastric acid secretion Pathways in cancer 0 -0.548418972 0 kegg kegg NA NA no no no no no no Gemmiger Pathways in cancer 0 0.437191114 0 butyrate-producing Genus kegg 0.595 NA no no no no no no Glucagon signaling pathway Pathways in cancer 0 0 0.54028314 kegg kegg NA NA no no no no no no Glutamatergic synapse Pathways in cancer 0 0.53458498 0 kegg kegg NA NA no up up no no no Glutathione metabolism Pathways in cancer -0.524347826 0 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Pathways in cancer 0 0.580039526 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Pathways in cancer 0.446956522 0.496047431 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Pathways in cancer -0.434782609 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Pathways in cancer -0.713043478 -0.740118577 -0.50965251 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Pathways in cancer 0 0.677865613 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Pathways in cancer -0.55826087 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Pathways in cancer 0 0.54743083 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Pathways in cancer 0 0 0.400514801 kegg kegg NA NA no no no no no no GnRH secretion Pathways in cancer 0.689565217 0.712450593 0 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Pathways in cancer 0.506086957 0.668972332 0.545173745 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Pathways in cancer 0.737391304 0 0.425740026 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Pathways in cancer 0 -0.553359684 0 kegg kegg NA NA no no no no no no Hepatitis B Pathways in cancer 0.643478261 0.693675889 0.541570142 kegg kegg NA NA no no no no no no Hepatitis C Pathways in cancer 0.515652174 0 0.681338481 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Pathways in cancer 0 -0.548418972 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Pathways in cancer 0 -0.545454545 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Pathways in cancer 0 0.477272727 0 kegg kegg NA NA no no no no no no Histidine metabolism Pathways in cancer -0.432173913 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Pathways in cancer -0.413913043 0 0 kegg kegg NA NA no no no no no no Huntington disease Pathways in cancer 0.605217391 -0.437747036 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Pathways in cancer 0 0 0.413127413 kegg kegg NA NA no no no no no no Influenza A Pathways in cancer 0 0 -0.493951094 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Pathways in cancer 0 0.469367589 0 kegg kegg NA NA no no no no no no Insulin resistance Pathways in cancer 0.679130435 0.765810277 0.539253539 kegg kegg NA NA no no no no no no Insulin secretion Pathways in cancer 0 0 0.410810811 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Pathways in cancer 0 -0.483201581 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Pathways in cancer 0 0.769762846 0.525353925 kegg kegg NA NA no no no no no no Leishmaniasis Pathways in cancer -0.450434783 -0.565217391 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Pathways in cancer 0 -0.436758893 -0.458944659 kegg kegg NA NA no no no no no no Long-term potentiation Pathways in cancer 0.573913043 -0.533596838 0 kegg kegg NA NA no no up no no no Lysosome Pathways in cancer 0 0 -0.444530245 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Pathways in cancer 0.496521739 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Pathways in cancer 0.419130435 0 0 kegg kegg NA NA no no no no no no Melanogenesis Pathways in cancer 0 0 0.402831403 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Pathways in cancer -0.486956522 -0.712450593 -0.576833977 kegg kegg NA NA no no no no no no mRNA surveillance pathway Pathways in cancer 0.74 0 0.455598456 kegg kegg NA NA no no no no no no mTOR signaling pathway Pathways in cancer 0 -0.433794466 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Pathways in cancer -0.556521739 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Pathways in cancer 0.612173913 0.475296443 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Pathways in cancer 0 0 -0.482625483 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Pathways in cancer 0 0.708498024 0.493693694 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Pathways in cancer 0 0.453557312 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Pathways in cancer 0 0.437747036 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Pathways in cancer 0.671304348 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Pathways in cancer -0.557391304 -0.613636364 0 kegg kegg NA NA no no no no no no Notch signaling pathway Pathways in cancer 0.513913043 0.610671937 0 kegg kegg NA NA no no no no no no Oocyte meiosis Pathways in cancer 0 -0.616600791 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Pathways in cancer 0.539130435 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Pathways in cancer 0.549565217 -0.437747036 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Pathways in cancer -0.430434783 -0.445652174 -0.473359073 kegg kegg NA NA no no no no no no p53 signaling pathway Pathways in cancer 0.633043478 0.511857708 0.556756757 kegg kegg NA NA no no no no no no Parabacteroides Pathways in cancer -0.539130435 0 0 Genus kegg 4.19E-05 NA no up up no no no Parkinson disease Pathways in cancer 0 -0.418972332 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Pathways in cancer 0 0 -0.513256113 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Pathways in cancer 0 -0.552371542 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Pathways in cancer -0.493913043 0 -0.402316602 kegg kegg NA NA no no no no no no Phagosome Pathways in cancer -0.610434783 0 -0.544144144 kegg kegg NA NA no no no no no no Phenylalanine metabolism Pathways in cancer -0.6 -0.532608696 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Pathways in cancer 0.751304348 0 0.409009009 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Pathways in cancer 0 0.65513834 0 kegg kegg NA NA no up up no no no Phototransduction Pathways in cancer 0 -0.766798419 0 kegg kegg NA NA no no no no no no Platelet activation Pathways in cancer -0.446956522 -0.548418972 0 kegg kegg NA NA no no no no no no Platinum drug resistance Pathways in cancer 0.446086957 0.441699605 0.4996139 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Pathways in cancer -0.471304348 0 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Pathways in cancer 0 -0.651185771 0 kegg kegg NA NA no no no no no no Prion disease Pathways in cancer 0.507826087 -0.517786561 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Pathways in cancer 0.55826087 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Pathways in cancer 0.495652174 0.548418972 0.406435006 kegg kegg NA NA no no no no no no Propanoate metabolism Pathways in cancer 0 -0.585968379 0 kegg kegg NA NA no no no no no no Proteasome Pathways in cancer 0 -0.802371542 0 kegg kegg NA NA no no no no no no Protein export Pathways in cancer 0.463478261 -0.602766798 0 kegg kegg NA NA no no no no no no Pyramidobacter Pathways in cancer 0 0 0.444287076 Genus kegg 0.45 NA no no no no no no Pyrimidine metabolism Pathways in cancer -0.54173913 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Pathways in cancer 0 -0.588932806 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Pathways in cancer -0.48173913 -0.583003953 -0.404890605 kegg kegg NA NA no no no no no no Relaxin signaling pathway Pathways in cancer 0.48 0.601778656 0 kegg kegg NA NA no no no no no no Retinol metabolism Pathways in cancer -0.445217391 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Pathways in cancer 0.47826087 -0.464426877 0 kegg kegg NA NA no no up no no no Ribosome Pathways in cancer 0 -0.523715415 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Pathways in cancer 0.412173913 0.656126482 0.493178893 kegg kegg NA NA no no no no no no RNA degradation Pathways in cancer 0.645217391 0 0 kegg kegg NA NA no no no no no no RNA polymerase Pathways in cancer 0.415652174 0 0 kegg kegg NA NA no no no no no no RNA transport Pathways in cancer 0 -0.470355731 0 kegg kegg NA NA no no no no no no Ruminococcus Pathways in cancer 0 -0.553245877 0 Genus kegg 0.0679 NA no no dn no no no Salmonella infection Pathways in cancer 0 0 -0.415186615 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Pathways in cancer 0.826956522 0.497035573 0.64041184 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Pathways in cancer 0 0.492094862 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Pathways in cancer 0.639130435 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Pathways in cancer 0.633043478 0 0 kegg kegg NA NA no no no no no no Spliceosome Pathways in cancer 0 0 0.522265122 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Pathways in cancer -0.525217391 0 -0.528957529 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Pathways in cancer 0 0 -0.433719434 kegg kegg NA NA no no no no no no Steroid biosynthesis Pathways in cancer 0 -0.530632411 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Pathways in cancer -0.563478261 -0.498023715 0 kegg kegg NA NA no no no no no no Sulfur metabolism Pathways in cancer -0.622608696 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Pathways in cancer 0 0 -0.487001287 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Pathways in cancer 0.432173913 0.523715415 0.480566281 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Pathways in cancer 0.533043478 0.661067194 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Pathways in cancer 0.446956522 -0.481225296 0 kegg kegg NA NA no no no no no no Thermogenesis Pathways in cancer 0.493913043 -0.473320158 0 kegg kegg NA NA no no no no no no Thiamine metabolism Pathways in cancer 0 -0.453557312 0 kegg kegg NA NA no no no no no no Tight junction Pathways in cancer -0.549565217 -0.688735178 -0.694465894 kegg kegg NA NA no no no no no no TNF signaling pathway Pathways in cancer 0.491304348 0.670948617 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Pathways in cancer 0 0.484189723 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Pathways in cancer -0.602608696 -0.641304348 0 kegg kegg NA NA no up no no no no Tuberculosis Pathways in cancer 0 0 -0.552638353 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Pathways in cancer -0.551304348 0 -0.433719434 kegg kegg NA NA no no no no no no Type II diabetes mellitus Pathways in cancer 0.548695652 0.791501976 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Pathways in cancer -0.527826087 -0.504940711 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Pathways in cancer -0.453043478 -0.551383399 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Pathways in cancer 0 -0.447628458 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Pathways in cancer 0.643478261 0.568181818 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Pathways in cancer 0 -0.522727273 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Pathways in cancer 0.613043478 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Pathways in cancer 0.546086957 0 0 kegg kegg NA NA no no no no no no Yersinia infection Pathways in cancer 0 0 -0.435006435 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Pathways of neurodegeneration - multiple diseases -0.449565217 0 0 kegg kegg NA NA no no no no no no ABC transporters Pathways of neurodegeneration - multiple diseases -0.503478261 0 0 kegg kegg NA NA no up up no no no Adherens junction Pathways of neurodegeneration - multiple diseases 0 0.529644269 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Pathways of neurodegeneration - multiple diseases 0.470434783 0 0.423680824 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Pathways of neurodegeneration - multiple diseases 0.769565217 0.824110672 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Pathways of neurodegeneration - multiple diseases 0 -0.76284585 -0.574517375 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Pathways of neurodegeneration - multiple diseases -0.587826087 -0.646245059 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Pathways of neurodegeneration - multiple diseases 0.72 0.787549407 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Pathways of neurodegeneration - multiple diseases 0 0 -0.742084942 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Pathways of neurodegeneration - multiple diseases -0.643478261 -0.708498024 -0.439124839 kegg kegg NA NA no no no no no no Alzheimer disease Pathways of neurodegeneration - multiple diseases 0.826086957 0.960474308 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Pathways of neurodegeneration - multiple diseases -0.582608696 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Pathways of neurodegeneration - multiple diseases -0.595652174 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Pathways of neurodegeneration - multiple diseases 0 0.542490119 0.511196911 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases 0.88173913 0.935770751 0.465379665 kegg kegg NA NA no no no no no no Apelin signaling pathway Pathways of neurodegeneration - multiple diseases 0.436521739 0.722332016 0 kegg kegg NA NA no no no no no no Apoptosis Pathways of neurodegeneration - multiple diseases -0.473913043 -0.572134387 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Pathways of neurodegeneration - multiple diseases 0 0 0.404118404 kegg kegg NA NA no no no no no no Arginine and proline metabolism Pathways of neurodegeneration - multiple diseases -0.480869565 -0.71541502 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Pathways of neurodegeneration - multiple diseases -0.613913043 -0.593873518 0 kegg kegg NA NA no no no no no no Autophagy - animal Pathways of neurodegeneration - multiple diseases 0 -0.606719368 -0.577863578 kegg kegg NA NA no no no no no no Axon guidance Pathways of neurodegeneration - multiple diseases 0.430434783 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.587944664 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Pathways of neurodegeneration - multiple diseases -0.69826087 0 0 kegg kegg NA NA no no no no no no Bile secretion Pathways of neurodegeneration - multiple diseases 0.605217391 0.528656126 0.536936937 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Pathways of neurodegeneration - multiple diseases -0.751304348 -0.615612648 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Pathways of neurodegeneration - multiple diseases 0 0.451581028 0.408751609 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Pathways of neurodegeneration - multiple diseases -0.58 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Pathways of neurodegeneration - multiple diseases -0.500869565 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.549407115 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Pathways of neurodegeneration - multiple diseases 0.71826087 0.714426877 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Pathways of neurodegeneration - multiple diseases 0.73826087 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Pathways of neurodegeneration - multiple diseases 0 -0.46541502 -0.645817246 kegg kegg NA NA no no no no no no Carbon metabolism Pathways of neurodegeneration - multiple diseases -0.663478261 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Pathways of neurodegeneration - multiple diseases 0.787826087 0.910079051 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Pathways of neurodegeneration - multiple diseases -0.485217391 -0.496047431 0 kegg kegg NA NA no no no no no no Cellular senescence Pathways of neurodegeneration - multiple diseases 0 -0.450592885 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.64229249 -0.436550837 kegg kegg NA NA no no no no no no Chemokine signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.448616601 0 kegg kegg NA NA no no no no no no Cholinergic synapse Pathways of neurodegeneration - multiple diseases 0 -0.449604743 -0.46975547 kegg kegg NA NA no no no no no no Circadian entrainment Pathways of neurodegeneration - multiple diseases 0.439130435 0.503952569 0.514285714 kegg kegg NA NA no up up no no no Circadian rhythm Pathways of neurodegeneration - multiple diseases 0.59826087 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Pathways of neurodegeneration - multiple diseases -0.58173913 -0.656126482 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Pathways of neurodegeneration - multiple diseases 0.62173913 0.493083004 0.442213642 kegg kegg NA NA no no up no no no Cushing syndrome Pathways of neurodegeneration - multiple diseases 0.613913043 0.530632411 0 kegg kegg NA NA no no up no no no Cytokine-cytokine receptor interaction Pathways of neurodegeneration - multiple diseases 0 -0.484189723 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Pathways of neurodegeneration - multiple diseases 0.733913043 0.670948617 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Pathways of neurodegeneration - multiple diseases 0 0.433794466 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Pathways of neurodegeneration - multiple diseases -0.522608696 0.46541502 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Pathways of neurodegeneration - multiple diseases 0 0.659090909 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Pathways of neurodegeneration - multiple diseases 0.649565217 0.802371542 0.541570142 kegg kegg NA NA no no no no no no Endocrine resistance Pathways of neurodegeneration - multiple diseases 0.49826087 0 0 kegg kegg NA NA no no no no no no Endocytosis Pathways of neurodegeneration - multiple diseases -0.426086957 -0.516798419 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.448616601 -0.576833977 kegg kegg NA NA no no no no no no Ether lipid metabolism Pathways of neurodegeneration - multiple diseases 0.775652174 0.457509881 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Pathways of neurodegeneration - multiple diseases -0.614782609 -0.593873518 -0.45019305 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Pathways of neurodegeneration - multiple diseases -0.613913043 -0.736166008 0 kegg kegg NA NA no no no no no no Fatty acid degradation Pathways of neurodegeneration - multiple diseases -0.850434783 -0.781620553 0 kegg kegg NA NA no no no no no no Fatty acid elongation Pathways of neurodegeneration - multiple diseases -0.585217391 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Pathways of neurodegeneration - multiple diseases -0.914782609 -0.780632411 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.679841897 -0.573745174 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Pathways of neurodegeneration - multiple diseases -0.740869565 -0.662055336 0 kegg kegg NA NA no no no no no no Ferroptosis Pathways of neurodegeneration - multiple diseases 0.452173913 0 0.627541828 kegg kegg NA NA no no no no no no FoxO signaling pathway Pathways of neurodegeneration - multiple diseases -0.415652174 -0.722332016 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Pathways of neurodegeneration - multiple diseases -0.626956522 -0.495059289 0 kegg kegg NA NA no no no no no no GABAergic synapse Pathways of neurodegeneration - multiple diseases -0.473913043 -0.559288538 0 kegg kegg NA NA no up up no no no Galactose metabolism Pathways of neurodegeneration - multiple diseases -0.757391304 -0.787549407 -0.416731017 kegg kegg NA NA no no no no no no Gastric acid secretion Pathways of neurodegeneration - multiple diseases 0 0.62944664 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Pathways of neurodegeneration - multiple diseases 0.525217391 0.778656126 0 kegg kegg NA NA no no no no no no Glutathione metabolism Pathways of neurodegeneration - multiple diseases 0 0.713438735 0.574774775 kegg kegg NA NA no no no no no no Glycerolipid metabolism Pathways of neurodegeneration - multiple diseases 0 -0.604743083 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Pathways of neurodegeneration - multiple diseases 0 0.492094862 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Pathways of neurodegeneration - multiple diseases -0.603478261 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Pathways of neurodegeneration - multiple diseases 0 -0.678853755 -0.406692407 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Pathways of neurodegeneration - multiple diseases 0.600869565 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Pathways of neurodegeneration - multiple diseases 0 -0.482213439 -0.502445302 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Pathways of neurodegeneration - multiple diseases 0.426086957 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Pathways of neurodegeneration - multiple diseases -0.717391304 -0.602766798 0 kegg kegg NA NA no no no no no no GnRH secretion Pathways of neurodegeneration - multiple diseases 0 0 -0.416216216 kegg kegg NA NA no up up no no no GnRH signaling pathway Pathways of neurodegeneration - multiple diseases 0.599130435 0.553359684 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Pathways of neurodegeneration - multiple diseases -0.409565217 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Pathways of neurodegeneration - multiple diseases 0 0.617588933 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Pathways of neurodegeneration - multiple diseases 0 0.513833992 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Pathways of neurodegeneration - multiple diseases 0 -0.699604743 -0.592277992 kegg kegg NA NA no no no no no no Histidine metabolism Pathways of neurodegeneration - multiple diseases -0.507826087 0 -0.431660232 kegg kegg NA NA no no no no no no Huntington disease Pathways of neurodegeneration - multiple diseases 0.844347826 0.960474308 0.515315315 kegg kegg NA NA no no no no no no IL-17 signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.520750988 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Pathways of neurodegeneration - multiple diseases 0.631304348 0.756916996 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Pathways of neurodegeneration - multiple diseases -0.424347826 -0.451581028 0 kegg kegg NA NA no no no no no no Insulin resistance Pathways of neurodegeneration - multiple diseases 0 -0.459486166 0 kegg kegg NA NA no no no no no no Insulin secretion Pathways of neurodegeneration - multiple diseases 0.579130435 0.599802372 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Pathways of neurodegeneration - multiple diseases 0 0.668972332 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Pathways of neurodegeneration - multiple diseases -0.466086957 -0.657114625 0 kegg kegg NA NA no no no no no no Long-term depression Pathways of neurodegeneration - multiple diseases 0.666086957 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Pathways of neurodegeneration - multiple diseases 0.454782609 0 0.508108108 kegg kegg NA NA no no no no no no Lysosome Pathways of neurodegeneration - multiple diseases 0 -0.43083004 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Pathways of neurodegeneration - multiple diseases 0.539130435 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.660079051 -0.564993565 kegg kegg NA NA no no no no no no Melanogenesis Pathways of neurodegeneration - multiple diseases 0.600869565 0.822134387 0.44967825 kegg kegg NA NA no no no no no no Mineral absorption Pathways of neurodegeneration - multiple diseases 0.72 0.661067194 0.758815959 kegg kegg NA NA no no no no no no Mitophagy - animal Pathways of neurodegeneration - multiple diseases 0.883478261 0.924901186 0.829086229 kegg kegg NA NA no no no no no no mRNA surveillance pathway Pathways of neurodegeneration - multiple diseases 0.714782609 0.630434783 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Pathways of neurodegeneration - multiple diseases 0.417391304 0.66798419 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Pathways of neurodegeneration - multiple diseases 0 -0.443675889 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Pathways of neurodegeneration - multiple diseases 0 0.462450593 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Pathways of neurodegeneration - multiple diseases 0 -0.457509881 0 kegg kegg NA NA no no no no no no Necroptosis Pathways of neurodegeneration - multiple diseases 0.58 0.437747036 0.671557272 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Pathways of neurodegeneration - multiple diseases 0 -0.572134387 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Pathways of neurodegeneration - multiple diseases 0.468695652 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Pathways of neurodegeneration - multiple diseases -0.593043478 -0.561264822 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Pathways of neurodegeneration - multiple diseases -0.427826087 -0.618577075 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Pathways of neurodegeneration - multiple diseases -0.590434783 -0.681818182 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Pathways of neurodegeneration - multiple diseases -0.425217391 -0.488142292 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Pathways of neurodegeneration - multiple diseases -0.630434783 -0.666007905 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Pathways of neurodegeneration - multiple diseases 0.852173913 0.942687747 0.593050193 kegg kegg NA NA no no no no no no Non-homologous end-joining Pathways of neurodegeneration - multiple diseases -0.655652174 0 0 kegg kegg NA NA no no no no no no Olfactory transduction Pathways of neurodegeneration - multiple diseases -0.415652174 -0.588932806 0 kegg kegg NA NA no no no no no no Oscillospira Pathways of neurodegeneration - multiple diseases 0 -0.457509881 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Pathways of neurodegeneration - multiple diseases -0.48173913 -0.707509881 0 kegg kegg NA NA no no no no no no Other glycan degradation Pathways of neurodegeneration - multiple diseases 0 -0.499011858 -0.507335907 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Pathways of neurodegeneration - multiple diseases 0.423478261 0.421936759 0.451222651 kegg kegg NA NA no up up no no no Oxidative phosphorylation Pathways of neurodegeneration - multiple diseases 0.809565217 0.945652174 0.420592021 kegg kegg NA NA no no no no no no Pancreatic secretion Pathways of neurodegeneration - multiple diseases 0.766956522 0.688735178 0.431917632 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Pathways of neurodegeneration - multiple diseases -0.595652174 -0.751976285 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Pathways of neurodegeneration - multiple diseases 0.847826087 0.846837945 0.59047619 kegg kegg NA NA no no no no no no Parkinson disease Pathways of neurodegeneration - multiple diseases 0.997391304 0.995059289 0.989446589 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Pathways of neurodegeneration - multiple diseases 0 0.438735178 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Pathways of neurodegeneration - multiple diseases -0.446086957 -0.614624506 0 kegg kegg NA NA no no no no no no Peroxisome Pathways of neurodegeneration - multiple diseases -0.750434783 -0.656126482 0 kegg kegg NA NA no no no no no no Phagosome Pathways of neurodegeneration - multiple diseases -0.517391304 -0.515810277 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Pathways of neurodegeneration - multiple diseases 0.432173913 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.47826087 0 kegg kegg NA NA no up up no no no Phototransduction Pathways of neurodegeneration - multiple diseases 0 0.459486166 0 kegg kegg NA NA no no no no no no Platelet activation Pathways of neurodegeneration - multiple diseases 0 0.429841897 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Pathways of neurodegeneration - multiple diseases 0 0.526679842 0.477220077 kegg kegg NA NA no no no no no no PPAR signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.546442688 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Pathways of neurodegeneration - multiple diseases -0.46173913 0 0 kegg kegg NA NA no no no no no no Prion disease Pathways of neurodegeneration - multiple diseases 0.75826087 0.916007905 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.627470356 -0.441441441 kegg kegg NA NA no no no no no no Proteasome Pathways of neurodegeneration - multiple diseases 0 0.435770751 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Pathways of neurodegeneration - multiple diseases -0.77826087 -0.846837945 -0.638610039 yes kegg kegg NA NA no up up no no no Protein export Pathways of neurodegeneration - multiple diseases 0.531304348 0.705533597 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Pathways of neurodegeneration - multiple diseases 0.433913043 0.59486166 0.607979408 kegg kegg NA NA no no no no no no Purine metabolism Pathways of neurodegeneration - multiple diseases 0 0.535573123 0.553153153 kegg kegg NA NA no no no no no no Pyrimidine metabolism Pathways of neurodegeneration - multiple diseases -0.687826087 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Pathways of neurodegeneration - multiple diseases 0 0.52173913 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Pathways of neurodegeneration - multiple diseases 0.503478261 0 0.415186615 kegg kegg NA NA no no no no no no Relaxin signaling pathway Pathways of neurodegeneration - multiple diseases 0.682608696 0 0 kegg kegg NA NA no no no no no no Renin secretion Pathways of neurodegeneration - multiple diseases 0.479130435 0.780632411 0.538223938 kegg kegg NA NA no no no no no no Renin-angiotensin system Pathways of neurodegeneration - multiple diseases 0 -0.647233202 -0.422136422 kegg kegg NA NA no no no no no no Retinol metabolism Pathways of neurodegeneration - multiple diseases -0.613913043 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Pathways of neurodegeneration - multiple diseases 0.554782609 0.867588933 0 kegg kegg NA NA no no up no no no Ribosome Pathways of neurodegeneration - multiple diseases 0.827826087 0.858695652 0.574002574 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.565217391 0 kegg kegg NA NA no no no no no no RNA degradation Pathways of neurodegeneration - multiple diseases 0.675652174 0.590909091 0 kegg kegg NA NA no no no no no no RNA polymerase Pathways of neurodegeneration - multiple diseases 0 0.533596838 0 kegg kegg NA NA no no no no no no RNA transport Pathways of neurodegeneration - multiple diseases 0 0.542490119 0 kegg kegg NA NA no no no no no no Ruminococcus Pathways of neurodegeneration - multiple diseases 0.410434783 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Signaling pathways regulating pluripotency of stem cells Pathways of neurodegeneration - multiple diseases 0.42173913 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Pathways of neurodegeneration - multiple diseases 0 -0.64229249 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Pathways of neurodegeneration - multiple diseases 0 0 -0.505276705 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Pathways of neurodegeneration - multiple diseases 0 0 -0.576833977 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Pathways of neurodegeneration - multiple diseases -0.591304348 -0.767786561 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Pathways of neurodegeneration - multiple diseases 0 -0.563241107 0 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.454545455 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Pathways of neurodegeneration - multiple diseases 0.646086957 0.578063241 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Pathways of neurodegeneration - multiple diseases 0 -0.45256917 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Pathways of neurodegeneration - multiple diseases 0 -0.437747036 0 kegg kegg NA NA no no no no no no Thermogenesis Pathways of neurodegeneration - multiple diseases 0.86 0.93083004 0.499099099 kegg kegg NA NA no no no no no no Thiamine metabolism Pathways of neurodegeneration - multiple diseases 0 0.428853755 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Pathways of neurodegeneration - multiple diseases 0 0.522727273 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Pathways of neurodegeneration - multiple diseases 0.553043478 0.664031621 0.598970399 kegg kegg NA NA no no no no no no Tight junction Pathways of neurodegeneration - multiple diseases 0 0.438735178 0 kegg kegg NA NA no no no no no no TNF signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.485177866 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.57312253 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Pathways of neurodegeneration - multiple diseases -0.56 0 0 kegg kegg NA NA no up no no no no Type I diabetes mellitus Pathways of neurodegeneration - multiple diseases 0 -0.415019763 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Pathways of neurodegeneration - multiple diseases 0 -0.568181818 -0.649420849 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Pathways of neurodegeneration - multiple diseases -0.412173913 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Pathways of neurodegeneration - multiple diseases 0.888695652 0.934782609 0.840926641 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Pathways of neurodegeneration - multiple diseases -0.451304348 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Pathways of neurodegeneration - multiple diseases 0.891304348 0.82312253 0.491891892 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Pathways of neurodegeneration - multiple diseases 0.674782609 0.746047431 0.593050193 kegg kegg NA NA no no no no no no VEGF signaling pathway Pathways of neurodegeneration - multiple diseases 0 -0.461462451 -0.501415701 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Pathways of neurodegeneration - multiple diseases 0.46173913 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Pathways of neurodegeneration - multiple diseases 0.664347826 0.550395257 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.594782609 -0.520750988 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia PD-L1 expression and PD-1 checkpoint pathway in cancer 0.580869565 0.631422925 0.45971686 kegg kegg NA NA no no no no no no Adherens junction PD-L1 expression and PD-1 checkpoint pathway in cancer -0.479130435 -0.742094862 -0.470527671 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.7756917 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.421936759 0 kegg kegg NA NA no no up no no no African trypanosomiasis PD-L1 expression and PD-1 checkpoint pathway in cancer 0.46173913 0.433794466 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.654150198 0.466409266 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.686758893 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.445652174 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption PD-L1 expression and PD-1 checkpoint pathway in cancer 0.686086957 0.453557312 0 kegg kegg NA NA no no no no no no Alzheimer disease PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.548418972 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.427826087 0 0 kegg kegg NA NA no no no no no no Amoebiasis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.514822134 0 kegg kegg NA NA no no no no no no Amphetamine addiction PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.62944664 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.583003953 0 kegg kegg NA NA no no no no no no Apelin signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.592885375 0 kegg kegg NA NA no no no no no no Apoptosis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.688735178 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.597391304 0 -0.668468468 kegg kegg NA NA no no no no no no Arginine and proline metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.627470356 0 kegg kegg NA NA no up no no no no Arginine biosynthesis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.658102767 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.44173913 -0.509881423 0 kegg kegg NA NA no no no no no no Autophagy - animal PD-L1 expression and PD-1 checkpoint pathway in cancer 0.747826087 0.894268775 0 kegg kegg NA NA no no no no no no Autophagy - other PD-L1 expression and PD-1 checkpoint pathway in cancer 0.693913043 0.627470356 0.662805663 kegg kegg NA NA no no no no no no Axon guidance PD-L1 expression and PD-1 checkpoint pathway in cancer 0.509565217 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.492173913 0.829051383 0.521492921 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells PD-L1 expression and PD-1 checkpoint pathway in cancer -0.504347826 -0.664031621 -0.551608752 kegg kegg NA NA no no no no no no Basal cell carcinoma PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 0.652252252 kegg kegg NA NA no no no no no no beta-Alanine metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.684347826 -0.583003953 -0.542857143 kegg kegg NA NA no no no no no no Bile secretion PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.427865613 -0.401029601 kegg kegg NA NA no no no no no no Biosynthesis of amino acids PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.433794466 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors PD-L1 expression and PD-1 checkpoint pathway in cancer -0.571304348 -0.480237154 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids PD-L1 expression and PD-1 checkpoint pathway in cancer -0.58173913 -0.505928854 -0.535392535 kegg kegg NA NA no no no no no no Bladder cancer PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.701581028 0 kegg kegg NA NA no no no no no no Breast cancer PD-L1 expression and PD-1 checkpoint pathway in cancer 0.813043478 0.761857708 0.650965251 kegg kegg NA NA no no no no no no Butanoate metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.600869565 -0.704545455 0 kegg kegg NA NA no no no no no no Butyricimonas PD-L1 expression and PD-1 checkpoint pathway in cancer 0.407820703 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no C-type lectin receptor signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.844347826 0.886363636 0.701930502 kegg kegg NA NA no no no no no no cAMP signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.615652174 0.609683794 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption PD-L1 expression and PD-1 checkpoint pathway in cancer 0.816521739 0.603754941 0 kegg kegg NA NA no no no no no no Carbon metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.566086957 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.513833992 0 kegg kegg NA NA no no up no no no Cell cycle PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.448616601 0 kegg kegg NA NA no no no no no no Cellular senescence PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.494071146 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.439130435 0.462450593 0 kegg kegg NA NA no no no no no no Chagas disease PD-L1 expression and PD-1 checkpoint pathway in cancer 0.764347826 0.848814229 0.435778636 kegg kegg NA NA no no no no no no Chemokine signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.487826087 0.479249012 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer 0.786086957 0.681818182 0.512998713 kegg kegg NA NA no no no no no no Cholinergic synapse PD-L1 expression and PD-1 checkpoint pathway in cancer 0.653043478 0 0.436293436 kegg kegg NA NA no no no no no no Chronic myeloid leukemia PD-L1 expression and PD-1 checkpoint pathway in cancer 0.793913043 0.874505929 0.711969112 kegg kegg NA NA no no no no no no Circadian entrainment PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.783596838 -0.481853282 kegg kegg NA NA no up up no no no Circadian rhythm PD-L1 expression and PD-1 checkpoint pathway in cancer 0.648695652 0 0.547490347 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) PD-L1 expression and PD-1 checkpoint pathway in cancer -0.591304348 -0.708498024 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 -0.526640927 kegg kegg NA NA no no no no no no Collinsella PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 -0.596145022 Genus kegg 0.128 NA no no no no no no Colorectal cancer PD-L1 expression and PD-1 checkpoint pathway in cancer 0.584347826 0 0.569369369 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.507905138 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.685770751 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 -0.477477477 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.73715415 0.475160875 kegg kegg NA NA no no no no no no DNA replication PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.693675889 0 kegg kegg NA NA no no no no no no Dopaminergic synapse PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.666996047 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.833992095 -0.412097812 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes PD-L1 expression and PD-1 checkpoint pathway in cancer -0.62 -0.795454545 0 kegg kegg NA NA no no no no no no ECM-receptor interaction PD-L1 expression and PD-1 checkpoint pathway in cancer -0.408695652 -0.444664032 0 kegg kegg NA NA no up up no no no Endocrine and other factor-regulated calcium reabsorption PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.538537549 0 kegg kegg NA NA no no no no no no Endometrial cancer PD-L1 expression and PD-1 checkpoint pathway in cancer 0.714782609 0.7756917 0.724581725 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection PD-L1 expression and PD-1 checkpoint pathway in cancer 0.477391304 0.736166008 0 kegg kegg NA NA no no no no no no ErbB signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.64 0.613636364 0.583268983 kegg kegg NA NA no no no no no no Estrogen signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.743083004 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.646245059 0 kegg kegg NA NA no no no no no no Fatty acid degradation PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.444664032 0 kegg kegg NA NA no no no no no no Fatty acid elongation PD-L1 expression and PD-1 checkpoint pathway in cancer -0.7 -0.54743083 -0.497554698 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.474782609 0.741106719 0 kegg kegg NA NA no no no no no no Focal adhesion PD-L1 expression and PD-1 checkpoint pathway in cancer -0.532173913 -0.786561265 -0.432432432 kegg kegg NA NA no up up no no no FoxO signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.565217391 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.428853755 0 kegg kegg NA NA no no no no no no GABAergic synapse PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.414031621 0 kegg kegg NA NA no up up no no no Galactose metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.434782609 0.425889328 0 kegg kegg NA NA no no no no no no Gap junction PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 -0.416731017 kegg kegg NA NA no no no no no no Gastric acid secretion PD-L1 expression and PD-1 checkpoint pathway in cancer -0.553043478 -0.816205534 -0.564736165 kegg kegg NA NA no no no no no no Gastric cancer PD-L1 expression and PD-1 checkpoint pathway in cancer 0.406956522 0 0.563449163 kegg kegg NA NA no no no no no no Glioma PD-L1 expression and PD-1 checkpoint pathway in cancer 0.41826087 0 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.59486166 0 kegg kegg NA NA no no no no no no Glutathione metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.475652174 -0.625494071 -0.623680824 kegg kegg NA NA no no no no no no Glycerolipid metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.446640316 0.424195624 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" PD-L1 expression and PD-1 checkpoint pathway in cancer -0.48 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis PD-L1 expression and PD-1 checkpoint pathway in cancer -0.548695652 -0.599802372 -0.48957529 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.763833992 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin PD-L1 expression and PD-1 checkpoint pathway in cancer -0.553043478 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.464426877 0.456885457 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.665019763 0 kegg kegg NA NA no no no no no no GnRH secretion PD-L1 expression and PD-1 checkpoint pathway in cancer 0.669565217 0.654150198 0.519176319 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" PD-L1 expression and PD-1 checkpoint pathway in cancer 0.417391304 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 0.483397683 kegg kegg NA NA no no no no no no Hematopoietic cell lineage PD-L1 expression and PD-1 checkpoint pathway in cancer -0.52173913 -0.473320158 -0.5001287 kegg kegg NA NA no no no no no no Hepatitis B PD-L1 expression and PD-1 checkpoint pathway in cancer 0.847826087 0.895256917 0.802316602 kegg kegg NA NA no no no no no no Hepatitis C PD-L1 expression and PD-1 checkpoint pathway in cancer 0.746956522 0.817193676 0.726383526 kegg kegg NA NA no no no no no no Hepatocellular carcinoma PD-L1 expression and PD-1 checkpoint pathway in cancer -0.405217391 -0.678853755 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.457509881 0 kegg kegg NA NA no no no no no no Hippo signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer -0.602608696 -0.764822134 -0.401544402 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.502964427 0 kegg kegg NA NA no no no no no no Histidine metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.443478261 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.532608696 0 kegg kegg NA NA no no no no no no Huntington disease PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.548418972 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.453043478 0.472332016 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.660079051 0 kegg kegg NA NA no no no no no no Insulin resistance PD-L1 expression and PD-1 checkpoint pathway in cancer 0.846956522 0.901185771 0.817503218 kegg kegg NA NA no no no no no no Insulin signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.529644269 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.735177866 0 kegg kegg NA NA no no no no no no Lachnospira PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.471954549 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Linoleic acid metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.419960474 0 kegg kegg NA NA no no no no no no Long-term potentiation PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.486166008 0.406177606 kegg kegg NA NA no no up no no no Lysine degradation PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 0.424710425 kegg kegg NA NA no no no no no no Malaria PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.456521739 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis PD-L1 expression and PD-1 checkpoint pathway in cancer 0.409565217 0 0.435778636 kegg kegg NA NA no no no no no no MAPK signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 0.528700129 kegg kegg NA NA no no no no no no Measles PD-L1 expression and PD-1 checkpoint pathway in cancer 0.680869565 0 0.428314028 kegg kegg NA NA no no no no no no Melanogenesis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.608695652 0 kegg kegg NA NA no no no no no no Melanoma PD-L1 expression and PD-1 checkpoint pathway in cancer 0.830434783 0.825098814 0.686486486 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 PD-L1 expression and PD-1 checkpoint pathway in cancer -0.442608696 -0.834980237 -0.447619048 kegg kegg NA NA no no no no no no MicroRNAs in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.859683794 0.620592021 kegg kegg NA NA no no no no no no Mismatch repair PD-L1 expression and PD-1 checkpoint pathway in cancer -0.465217391 -0.68083004 0 kegg kegg NA NA no no no no no no Morphine addiction PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.488142292 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.467826087 0 0.418018018 kegg kegg NA NA no no no no no no N-Glycan biosynthesis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.625494071 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.8 0.850790514 0.721235521 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.528695652 0.895256917 0.728700129 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.601778656 0 kegg kegg NA NA no no no no no no Nicotine addiction PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 0.412870013 kegg kegg NA NA no up up no no no Nitrogen metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.626482213 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.825098814 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease PD-L1 expression and PD-1 checkpoint pathway in cancer 0.406956522 -0.436758893 0 kegg kegg NA NA no no no no no no Non-homologous end-joining PD-L1 expression and PD-1 checkpoint pathway in cancer -0.626956522 -0.605731225 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer 0.764347826 0.635375494 0.583783784 kegg kegg NA NA no no no no no no Notch signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.434782609 0.43037323 kegg kegg NA NA no no no no no no Nucleotide excision repair PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.651185771 0 kegg kegg NA NA no no no no no no One carbon pool by folate PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.71541502 0 kegg kegg NA NA no no no no no no Oocyte meiosis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.637351779 0 kegg kegg NA NA no no no no no no Osteoclast differentiation PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.701581028 0 kegg kegg NA NA no no no no no no Other glycan degradation PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.45256917 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.54743083 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer -0.537391304 -0.552371542 -0.673873874 kegg kegg NA NA no no no no no no Pancreatic cancer PD-L1 expression and PD-1 checkpoint pathway in cancer 0.413913043 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.59486166 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.446640316 0 kegg kegg NA NA no no dn no no no Parkinson disease PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.475296443 0 kegg kegg NA NA no no no no no no Pathways in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer 0.592173913 0.630434783 0.512483912 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.456521739 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions PD-L1 expression and PD-1 checkpoint pathway in cancer -0.591304348 -0.668972332 0 kegg kegg NA NA no no no no no no Peroxisome PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.511857708 0 kegg kegg NA NA no no no no no no Pertussis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.424901186 0 kegg kegg NA NA no no dn no no no Phenylalanine metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.705217391 -0.743083004 -0.423680824 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.626482213 0 kegg kegg NA NA no up up no no no Phototransduction PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.68083004 0 kegg kegg NA NA no no no no no no Platelet activation PD-L1 expression and PD-1 checkpoint pathway in cancer -0.54 -0.727272727 -0.482368082 kegg kegg NA NA no no no no no no PPAR signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.79743083 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis PD-L1 expression and PD-1 checkpoint pathway in cancer -0.594782609 -0.552371542 -0.572458172 kegg kegg NA NA no no no no no no Prion disease PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.595849802 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation PD-L1 expression and PD-1 checkpoint pathway in cancer 0.515652174 0 0.513513514 kegg kegg NA NA no no no no no no Prolactin signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.688695652 0.726284585 0.587902188 kegg kegg NA NA no no no no no no Propanoate metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.651185771 0 kegg kegg NA NA no no no no no no Prostate cancer PD-L1 expression and PD-1 checkpoint pathway in cancer 0.828695652 0.895256917 0.81981982 kegg kegg NA NA no no no no no no Proteasome PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.596837945 0 kegg kegg NA NA no no no no no no Protein digestion and absorption PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.462450593 0 yes kegg kegg NA NA no up up no no no Protein export PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.612648221 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.542490119 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.490118577 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.769762846 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.507826087 -0.732213439 0 kegg kegg NA NA no no no no no no Pyruvate metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.694664032 -0.401029601 kegg kegg NA NA no no no no no no Rap1 signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.527667984 0 kegg kegg NA NA no no no no no no Ras signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.663043478 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton PD-L1 expression and PD-1 checkpoint pathway in cancer -0.435652174 -0.677865613 -0.528442728 kegg kegg NA NA no no no no no no Relaxin signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.697391304 0.662055336 0 kegg kegg NA NA no no no no no no Renal cell carcinoma PD-L1 expression and PD-1 checkpoint pathway in cancer 0.543478261 0 0 kegg kegg NA NA no no no no no no Renin secretion PD-L1 expression and PD-1 checkpoint pathway in cancer -0.443478261 -0.776679842 -0.423166023 kegg kegg NA NA no no no no no no Retinol metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.456521739 -0.613636364 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.653162055 0 kegg kegg NA NA no no up no no no Ribosome PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.520750988 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.833913043 0.910079051 0.694980695 kegg kegg NA NA no no no no no no RNA degradation PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.495059289 0.452767053 kegg kegg NA NA no no no no no no RNA polymerase PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.48715415 0 kegg kegg NA NA no no no no no no Salivary secretion PD-L1 expression and PD-1 checkpoint pathway in cancer -0.42173913 -0.599802372 -0.43989704 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells PD-L1 expression and PD-1 checkpoint pathway in cancer 0.650434783 0 0.548262548 kegg kegg NA NA no no no no no no Small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer 0.570434783 0.889328063 0.594079794 kegg kegg NA NA no no up no no no SNARE interactions in vesicular transport PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.626482213 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.617391304 0.510869565 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia PD-L1 expression and PD-1 checkpoint pathway in cancer 0.666956522 0 0.462033462 kegg kegg NA NA no no no no no no Spliceosome PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 0.416216216 kegg kegg NA NA no no no no no no Staphylococcus aureus infection PD-L1 expression and PD-1 checkpoint pathway in cancer -0.431304348 0 0 kegg kegg NA NA up no no no no no Starch and sucrose metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.517786561 0 kegg kegg NA NA no no no no no no Steroid biosynthesis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.704545455 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis PD-L1 expression and PD-1 checkpoint pathway in cancer -0.605217391 -0.736166008 0 kegg kegg NA NA no no no no no no Sulfur metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.644347826 -0.441699605 -0.445302445 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.572134387 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.684347826 0.794466403 0.663063063 kegg kegg NA NA no no no no no no Taste transduction PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.532608696 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.551383399 0.452767053 kegg kegg NA NA no no no no no no TGF-beta signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.60770751 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.453557312 0 kegg kegg NA NA no no no no no no Th17 cell differentiation PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.563241107 0 kegg kegg NA NA no no no no no no Thermogenesis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.593873518 0 kegg kegg NA NA no no no no no no Thiamine metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.488142292 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.644268775 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 -0.423680824 kegg kegg NA NA no no no no no no Tight junction PD-L1 expression and PD-1 checkpoint pathway in cancer -0.56 -0.708498024 -0.703474903 kegg kegg NA NA no no no no no no TNF signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.910434783 0.92687747 0.694465894 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.769565217 0.841897233 0.505019305 yes kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer 0.703478261 0.837944664 0.716859717 kegg kegg NA NA no no no no no no Tryptophan metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.653043478 -0.674901186 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus PD-L1 expression and PD-1 checkpoint pathway in cancer 0.837391304 0.711462451 0.500900901 kegg kegg NA NA no no no no no no Tyrosine metabolism PD-L1 expression and PD-1 checkpoint pathway in cancer -0.713913043 -0.833992095 -0.56962677 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis PD-L1 expression and PD-1 checkpoint pathway in cancer -0.594782609 -0.640316206 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" PD-L1 expression and PD-1 checkpoint pathway in cancer -0.571304348 -0.701581028 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.446640316 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.664031621 -0.401544402 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.644268775 0 kegg kegg NA NA no no no no no no VEGF signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0.653913043 0.550395257 0.523809524 kegg kegg NA NA no no no no no no Vibrio cholerae infection PD-L1 expression and PD-1 checkpoint pathway in cancer -0.486086957 -0.736166008 -0.519176319 kegg kegg NA NA no no no no no no Viral carcinogenesis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.577075099 0 kegg kegg NA NA no no no no no no Wnt signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.552371542 0.462033462 kegg kegg NA NA no no no no no no 16:0-LPC+blood PDGF-bb 0 0 0.463157895 yes serum_phospholipids serum_cytokines 0.00456 0.111 up up no no no no 16:0/16:1-PC+blood PDGF-bb 0.648484848 0 0 yes serum_phospholipids serum_cytokines 0.00283 0.111 up up no no no no 16:0/18:0-PC+blood PDGF-bb 0 -0.660714286 0 yes serum_phospholipids serum_cytokines 0.521 0.111 no no no no no no 16:0/22:6-PC+blood PDGF-bb -0.76969697 0 0 yes serum_phospholipids serum_cytokines 4.53E-05 0.111 no up up no no no 16:1/16:1-PC+blood PDGF-bb 0 -0.528571429 0 yes serum_phospholipids serum_cytokines 0.0177 0.111 no no up no no no 16:1+blood PDGF-bb 0 0 -0.446616541 yes yes serum_fattyacid serum_cytokines 0.0186 0.111 no no dn no no no 18:0-LPC+blood PDGF-bb 0 0 0.615037594 yes serum_phospholipids serum_cytokines 0.554 0.111 no no no no no no 18:0-LPE+blood PDGF-bb 0 0 0.490225564 yes serum_phospholipids serum_cytokines 0.491 0.111 no no no no no no 18:0/18:0-PC+blood PDGF-bb 0 -0.617857143 0 yes serum_phospholipids serum_cytokines 0.426 0.111 no no no no no no 18:0/18:1-PC+blood PDGF-bb 0 -0.596428571 0 yes serum_phospholipids serum_cytokines 0.393 0.111 no no no no no no 18:0/20:5-PC+blood PDGF-bb -0.83030303 0 0 yes serum_phospholipids serum_cytokines 0.17 0.111 no no no no no no 18:0/22:6-PA+blood PDGF-bb 0 -0.610714286 0 yes serum_phospholipids serum_cytokines 0.22 0.111 no no no no no no 18:0/22:6-PC+blood PDGF-bb -0.672727273 0 0 yes serum_phospholipids serum_cytokines 0.0775 0.111 no no up no no no 18:1+blood PDGF-bb -0.636363636 0 -0.45112782 yes yes serum_fattyacid serum_cytokines 0.00202 0.111 up no dn no no no 18:2-LPA+blood PDGF-bb 0.781818182 0 0 yes serum_phospholipids serum_cytokines 0.00684 0.111 dn no up no no no 18:3n3+blood PDGF-bb -0.733333333 0 0 yes serum_fattyacid serum_cytokines 0.291 0.111 no no no no no no 20:3/18:0-PC+blood PDGF-bb 0 -0.528571429 0 yes serum_phospholipids serum_cytokines 0.296 0.111 no no no no no no 20:5/18:0-PC+blood PDGF-bb -0.648484848 0 0 yes serum_phospholipids serum_cytokines 3.97E-06 0.111 no up up no no no "9,10-EPOME+blood" PDGF-bb 0.675329831 0 0 yes serum_ARA serum_cytokines 0.801 0.111 no no no no no no Adipocytokine signaling pathway PDGF-bb 0 0.457142857 0 yes kegg serum_cytokines NA 0.111 no no no no no no Amoebiasis PDGF-bb -0.571428571 0.47518797 0 yes kegg serum_cytokines NA 0.111 no no no no no no Butyric acid+stool PDGF-bb 0 0 0.522058824 yes yes stool_scfa serum_cytokines 0.102 0.111 dn no no no no no C-type lectin receptor signaling pathway PDGF-bb 0 0.503759398 0 yes kegg serum_cytokines NA 0.111 no no no no no no Calcium signaling pathway PDGF-bb 0 0 0.45210728 yes kegg serum_cytokines NA 0.111 no up up no no no cAMP signaling pathway PDGF-bb 0 0.587969925 0 yes yes kegg serum_cytokines NA 0.111 no up up no no no cGMP-PKG signaling pathway PDGF-bb -0.642857143 0 0 yes kegg serum_cytokines NA 0.111 no no no no no no Chagas disease PDGF-bb 0 0.571428571 0 yes kegg serum_cytokines NA 0.111 no no no no no no Chronic myeloid leukemia PDGF-bb 0 0.467669173 0 yes kegg serum_cytokines NA 0.111 no no no no no no Cocaine addiction PDGF-bb 0 0 0.400656814 yes kegg serum_cytokines NA 0.111 no no no no no no Cysteine+blood PDGF-bb 0 0 -0.472180451 yes yes serum_aminoacids serum_cytokines 1.81E-07 0.111 dn up up no no no Cytosolic DNA-sensing pathway PDGF-bb 0 0.554887218 0 yes kegg serum_cytokines NA 0.111 no no no no no no d18:1-14:0-SM+blood PDGF-bb 0 -0.575 0 yes serum_phospholipids serum_cytokines 0.94 0.111 no no no no no no d18:1-20:0-SM+blood PDGF-bb 0 0 0.580451128 yes serum_phospholipids serum_cytokines 0.933 0.111 no no no no no no d18:1-22:1-SM+blood PDGF-bb 0 0 0.476691729 yes serum_phospholipids serum_cytokines 0.222 0.111 no no no no no no Dorea PDGF-bb 0 0 0.456061551 yes Genus serum_cytokines 0.00362 0.111 up no dn no no no DPA+blood PDGF-bb 0 0.535714286 0 yes serum_ARA serum_cytokines 0.519 0.111 no no no no no no Ethanolamine+blood PDGF-bb 0 0.539285714 0 yes serum_aminoacids serum_cytokines 0.122 0.111 up no no no no no Faecalibacterium PDGF-bb 0 0.484415584 0 butyrate-producing yes Genus serum_cytokines 0.0039 0.111 no dn dn no no no FoxO signaling pathway PDGF-bb -0.82967033 0 0 yes kegg serum_cytokines NA 0.111 no no no no no no GABAergic synapse PDGF-bb -0.71978022 0 0 yes kegg serum_cytokines NA 0.111 no up up no no no Glioma PDGF-bb -0.626373626 0 0 yes kegg serum_cytokines NA 0.111 no no no no no no Glutamatergic synapse PDGF-bb -0.637362637 0 0 yes kegg serum_cytokines NA 0.111 no up up no no no Glycolysis / Gluconeogenesis PDGF-bb 0 -0.527819549 0 yes kegg serum_cytokines NA 0.111 no no no no no no "Growth hormone synthesis, secretion and action" PDGF-bb 0 0.472180451 0 yes kegg serum_cytokines NA 0.111 no no no no no no HCA+stool PDGF-bb -0.709090909 0 0 yes stool_bileacids serum_cytokines 0.155 0.111 no no no no no no Hematopoietic cell lineage PDGF-bb 0 -0.47518797 -0.407224959 yes kegg serum_cytokines NA 0.111 no no no no no no IL-13 PDGF-bb 0 -0.592207792 -0.687208009 yes yes serum_cytokines serum_cytokines 0.00264 0.111 up up no no no no IL-1b PDGF-bb 0 -0.533766234 -0.53592881 yes yes serum_cytokines serum_cytokines 0.00358 0.111 up up no no no no IL-8 PDGF-bb -0.708791209 0 0 yes serum_cytokines serum_cytokines 0.579 0.111 no no no no no no iso-LCA+stool PDGF-bb 0.802435318 0 0 yes stool_bileacids serum_cytokines 0.72 0.111 no no no no no no L-Alanine+blood PDGF-bb 0 0 0.491729323 yes yes serum_aminoacids serum_cytokines 0.00138 0.111 up up no no no no L-Ornithine+blood PDGF-bb 0 0.553571429 0 yes serum_aminoacids serum_cytokines 0.175 0.111 no no no no no no L-Tryptophan+urine PDGF-bb 0 0 0.457894737 yes urine_cometabolism serum_cytokines 0.226 0.111 no no no no no no LCA+blood PDGF-bb 0.665903429 0 0 yes serum_bileacids serum_cytokines 0.884 0.111 no no no no no no LCA+stool PDGF-bb 0.793939394 0 0 yes stool_bileacids serum_cytokines 0.314 0.111 no no no no no no Long-term depression PDGF-bb 0 0.470676692 0 yes kegg serum_cytokines NA 0.111 no no no no no no MUFA+blood PDGF-bb -0.636363636 0 -0.47518797 yes serum_fattyacid serum_cytokines 0.00175 0.111 up no dn no no no Neurotrophin signaling pathway PDGF-bb 0 0.472180451 0 yes kegg serum_cytokines NA 0.111 no no no no no no nutriCA+stool PDGF-bb 0 -0.619733677 0 yes stool_bileacids serum_cytokines 0.481 0.111 no no no no no no Phospholipase D signaling pathway PDGF-bb 0 0.481203008 0.443349754 yes kegg serum_cytokines NA 0.111 no up up no no no Prevotella PDGF-bb 0 0 0.412068087 acetate-producing yes Genus serum_cytokines 0.287 0.111 no no no no no no Primary immunodeficiency PDGF-bb 0 -0.515789474 0 yes kegg serum_cytokines NA 0.111 no no no no no no Prolactin signaling pathway PDGF-bb 0 0.44962406 0 yes kegg serum_cytokines NA 0.111 no no no no no no Prostate cancer PDGF-bb 0 0.47518797 0 yes kegg serum_cytokines NA 0.111 no no no no no no Relaxin signaling pathway PDGF-bb 0 0.545864662 0 yes kegg serum_cytokines NA 0.111 no no no no no no Ruminococcus PDGF-bb 0 -0.503896104 0 acetate-producing yes Genus serum_cytokines 0.335 0.111 no no no no no no TNF signaling pathway PDGF-bb 0 0.452631579 0 yes kegg serum_cytokines NA 0.111 no no no no no no Transcriptional misregulation in cancer PDGF-bb 0 0.485714286 0 yes kegg serum_cytokines NA 0.111 no no no no no no Citrate cycle (TCA cycle) Pentose and glucuronate interconversions 0.749565217 0.934782609 0.685714286 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Pentose and glucuronate interconversions 0.630434783 0.643280632 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Pentose and glucuronate interconversions 0 -0.613636364 -0.496525097 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Pentose phosphate pathway 0 -0.416007905 0 kegg kegg NA NA no no no no no no Anaerococcus Peptoniphilus 0 0.488459192 0 Genus Genus 0.275 0.183 no no no no no no Peptoniphilus Peptostreptococcus 0 0 0.581587125 Genus Genus 0.183 0.533 no no no no no no 2-Oxocarboxylic acid metabolism Peroxisome 0 -0.591897233 0 kegg kegg NA NA no no no no no no ABC transporters Peroxisome 0.433913043 0 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" Peroxisome 0.76173913 0.854743083 0.790733591 kegg kegg NA NA no no no no no no Alistipes Peroxisome -0.407864151 0 0 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism Peroxisome 0.411304348 0.688735178 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Peroxisome 0.688695652 0.718379447 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Peroxisome 0.799130435 0.83201581 0.775289575 kegg kegg NA NA no no no no no no Autophagy - animal Peroxisome 0 0.62944664 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Peroxisome 0.540869565 0.743083004 0.688288288 kegg kegg NA NA no no no no no no Blautia Peroxisome 0.453043478 0.41798419 0 acetate-producing Genus kegg 1.36E-05 NA up dn dn no no no Butanoate metabolism Peroxisome 0 -0.433794466 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Peroxisome -0.55826087 -0.747035573 -0.597683398 kegg kegg NA NA no up up no no no cAMP signaling pathway Peroxisome -0.506086957 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Peroxisome 0 0 0.563449163 kegg kegg NA NA no no no no no no Cell cycle Peroxisome 0 -0.527667984 -0.554954955 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Peroxisome 0 0.688735178 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Peroxisome 0 0.453557312 0 kegg kegg NA NA no no no no no no Clostridium Peroxisome 0.419926257 0 0 Genus kegg 0.925 NA no no no no no no Coprococcus Peroxisome 0 0 0.40671858 butyrate-producing Genus kegg 0.612 NA no no no no no no Cytokine-cytokine receptor interaction Peroxisome 0 0.500988142 0 kegg kegg NA NA no no no no no no DNA replication Peroxisome 0 -0.504940711 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Peroxisome 0 -0.529644269 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Peroxisome 0 -0.58201581 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Peroxisome 0 -0.584980237 0 kegg kegg NA NA no no no no no no Endocrine resistance Peroxisome -0.573043478 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Peroxisome -0.557391304 -0.468379447 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Peroxisome 0.830434783 0.84486166 0.697297297 kegg kegg NA NA no no no no no no Fatty acid degradation Peroxisome 0.886086957 0.773715415 0.567824968 kegg kegg NA NA no no no no no no Fatty acid metabolism Peroxisome 0.862608696 0.836956522 0.528185328 kegg kegg NA NA no no no no no no Folate biosynthesis Peroxisome 0 -0.623517787 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Peroxisome 0.525217391 0.564229249 0 kegg kegg NA NA no no no no no no Galactose metabolism Peroxisome 0.414782609 0.621541502 0 kegg kegg NA NA no no no no no no Glutathione metabolism Peroxisome 0 -0.566205534 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Peroxisome 0.502608696 0.508893281 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Peroxisome 0 -0.586956522 -0.475418275 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Peroxisome -0.553043478 -0.62944664 -0.579407979 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Peroxisome 0 0.43972332 0 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Peroxisome 0.832173913 0.837944664 0.778893179 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Peroxisome 0 -0.482213439 0 kegg kegg NA NA no no no no no no Lysine degradation Peroxisome 0 0 -0.598712999 kegg kegg NA NA no no no no no no Lysosome Peroxisome 0 0.549407115 0.417503218 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Peroxisome -0.43826087 0 -0.639382239 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Peroxisome 0 -0.4743083 0 kegg kegg NA NA no no no no no no Mitophagy - animal Peroxisome -0.668695652 -0.501976285 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Peroxisome -0.487826087 -0.759881423 -0.656113256 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Peroxisome 0 -0.738142292 -0.433204633 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Peroxisome 0.459130435 0.640316206 0.584041184 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Peroxisome 0.445217391 0.596837945 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Peroxisome 0.872173913 0.789525692 0.636293436 kegg kegg NA NA no no no no no no Nitrogen metabolism Peroxisome 0.610434783 0.752964427 0.582496782 kegg kegg NA NA no no no no no no One carbon pool by folate Peroxisome 0 -0.479249012 0 kegg kegg NA NA no no no no no no Oocyte meiosis Peroxisome 0 0 -0.445559846 kegg kegg NA NA no no no no no no Oscillospira Peroxisome 0 0 0.415958816 LPS-producing Genus kegg 0.62 NA no no no no no no Other types of O-glycan biosynthesis Peroxisome 0 0 -0.471299871 kegg kegg NA NA no no no no no no Oxidative phosphorylation Peroxisome -0.548695652 -0.721343874 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Peroxisome 0.780869565 0.866600791 0.695238095 kegg kegg NA NA no no dn no no no Paraprevotella Peroxisome 0 -0.429077812 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Peroxisome 0 -0.604743083 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Peroxisome 0 0.666996047 0.684942085 kegg kegg NA NA no no no no no no Phagosome Peroxisome 0 0.461462451 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Peroxisome 0 -0.434782609 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Peroxisome 0 0 -0.528700129 kegg kegg NA NA no no no no no no PPAR signaling pathway Peroxisome 0.450434783 0.690711462 0 kegg kegg NA NA no no no no no no Protein export Peroxisome 0 -0.674901186 -0.425997426 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Peroxisome -0.406086957 -0.747035573 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Peroxisome 0.520869565 -0.477272727 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Peroxisome 0 -0.455533597 0 kegg kegg NA NA no no no no no no Ras signaling pathway Peroxisome 0 -0.688735178 -0.651222651 yes kegg kegg NA NA no up up no no no Retinol metabolism Peroxisome 0.436521739 0 0 kegg kegg NA NA no no no no no no Ribosome Peroxisome -0.586086957 -0.619565217 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Peroxisome 0 -0.441699605 -0.421879022 kegg kegg NA NA no no no no no no RNA degradation Peroxisome -0.48 -0.831027668 -0.615701416 kegg kegg NA NA no no no no no no RNA polymerase Peroxisome 0 -0.605731225 0 kegg kegg NA NA no no no no no no RNA transport Peroxisome 0 -0.500988142 0 kegg kegg NA NA no no no no no no Ruminococcus Peroxisome -0.54 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Starch and sucrose metabolism Peroxisome 0.590434783 0.838932806 0 kegg kegg NA NA no no no no no no Sulfur metabolism Peroxisome 0 0 0.45019305 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Peroxisome -0.76 -0.561264822 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Peroxisome 0 -0.583003953 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Pertussis 0 -0.5 0 kegg kegg NA NA no no no no no dn Adrenergic signaling in cardiomyocytes Pertussis 0 -0.752964427 -0.462805663 kegg kegg NA NA no no up no no dn AGE-RAGE signaling pathway in diabetic complications Pertussis 0 0.708498024 0 kegg kegg NA NA no no no no no dn Akkermansia Pertussis 0.466952184 0 0 acetate-producing Genus kegg 0.23 NA no no no no no dn "Alanine, aspartate and glutamate metabolism" Pertussis 0.466956522 0.68972332 0.612612613 kegg kegg NA NA no no no no no dn Aldosterone synthesis and secretion Pertussis -0.460869565 -0.900197628 -0.434491634 kegg kegg NA NA no up up no no dn alpha-Linolenic acid metabolism Pertussis 0 0.51284585 0 kegg kegg NA NA no no no no no dn Alzheimer disease Pertussis -0.453913043 -0.67687747 -0.52020592 kegg kegg NA NA no no no no no dn Aminoacyl-tRNA biosynthesis Pertussis 0 -0.46541502 0 kegg kegg NA NA no no no no no dn Amphetamine addiction Pertussis -0.526086957 -0.83201581 0 kegg kegg NA NA no no no no no dn AMPK signaling pathway Pertussis -0.480869565 -0.653162055 0 kegg kegg NA NA no no no no no dn Amyotrophic lateral sclerosis Pertussis -0.523478261 -0.745059289 -0.502702703 kegg kegg NA NA no no no no no dn Antifolate resistance Pertussis 0 -0.604743083 -0.465379665 kegg kegg NA NA no no no no no dn Antigen processing and presentation Pertussis 0.511304348 0.416996047 0.529214929 kegg kegg NA NA no no no no no dn Apelin signaling pathway Pertussis -0.508695652 -0.605731225 -0.542342342 kegg kegg NA NA no no no no no dn Apoptosis Pertussis 0.529565217 0.768774704 0.706821107 kegg kegg NA NA no no no no no dn Arginine and proline metabolism Pertussis 0.490434783 0.754940711 0.585328185 kegg kegg NA NA no up no no no dn Arginine biosynthesis Pertussis 0.530434783 0.720355731 0.693178893 kegg kegg NA NA no no no no no dn Autophagy - animal Pertussis 0 0.462450593 0 kegg kegg NA NA no no no no no dn B cell receptor signaling pathway Pertussis 0 0.648221344 0 kegg kegg NA NA no no no no no dn Basal transcription factors Pertussis 0 -0.589920949 -0.692406692 kegg kegg NA NA no no no no no dn Base excision repair Pertussis 0 -0.613636364 -0.611068211 kegg kegg NA NA no no no no no dn Biosynthesis of amino acids Pertussis 0.655652174 0.907114625 0.798712999 kegg kegg NA NA no no no no no dn Biosynthesis of cofactors Pertussis 0 -0.648221344 0 kegg kegg NA NA no no no no no dn Butanoate metabolism Pertussis 0 -0.458498024 0 kegg kegg NA NA no no no no no dn C-type lectin receptor signaling pathway Pertussis 0 0.654150198 0 kegg kegg NA NA no no no no no dn Calcium signaling pathway Pertussis 0 -0.639328063 -0.438867439 kegg kegg NA NA no up up no no dn Carbon metabolism Pertussis 0.524347826 0.514822134 0.621364221 kegg kegg NA NA no no no no no dn Cardiac muscle contraction Pertussis -0.431304348 -0.682806324 -0.476190476 kegg kegg NA NA no no up no no dn Cell adhesion molecules Pertussis 0.499130435 0.718379447 0.51016731 kegg kegg NA NA no no no no no dn Cell cycle Pertussis -0.433043478 -0.831027668 -0.704247104 kegg kegg NA NA no no no no no dn Cellular senescence Pertussis 0.497391304 0.657114625 0 kegg kegg NA NA no no no no no dn cGMP-PKG signaling pathway Pertussis 0 0.910079051 0.483912484 kegg kegg NA NA no no no no no dn Chemokine signaling pathway Pertussis 0 0.634387352 0.542599743 kegg kegg NA NA no no no no no dn Cholesterol metabolism Pertussis 0 0.632411067 0 yes kegg kegg NA NA no no up no no dn Circadian rhythm Pertussis -0.406086957 -0.776679842 -0.704761905 kegg kegg NA NA no no no no no dn Citrate cycle (TCA cycle) Pertussis 0 -0.416007905 0 kegg kegg NA NA no no no no no dn Cocaine addiction Pertussis -0.497391304 -0.636363636 0 kegg kegg NA NA no no no no no dn Complement and coagulation cascades Pertussis 0.609565217 0.838932806 0.807979408 kegg kegg NA NA no no no no no dn Cortisol synthesis and secretion Pertussis -0.522608696 -0.71541502 0 kegg kegg NA NA no no up no no dn Cushing syndrome Pertussis -0.662608696 -0.846837945 -0.496782497 kegg kegg NA NA no no up no no dn Cysteine and methionine metabolism Pertussis 0 -0.461462451 -0.541827542 kegg kegg NA NA no no no no no dn Cytokine-cytokine receptor interaction Pertussis 0.456521739 0.451581028 0 kegg kegg NA NA no no no no no dn DNA replication Pertussis 0 -0.682806324 -0.63963964 kegg kegg NA NA no no no no no dn Dopaminergic synapse Pertussis 0 -0.608695652 0 kegg kegg NA NA no up no no no dn Drug metabolism - cytochrome P450 Pertussis 0 -0.531620553 0 kegg kegg NA NA no no no no no dn EGFR tyrosine kinase inhibitor resistance Pertussis -0.583478261 -0.568181818 -0.507078507 kegg kegg NA NA no no no no no dn Endocrine and other factor-regulated calcium reabsorption Pertussis 0 -0.774703557 0 kegg kegg NA NA no no no no no dn Endocrine resistance Pertussis -0.428695652 -0.587944664 0 kegg kegg NA NA no no no no no dn Endocytosis Pertussis 0.57826087 0.763833992 0 kegg kegg NA NA no no no no no dn Epithelial cell signaling in Helicobacter pylori infection Pertussis 0.565217391 0.818181818 0.558558559 kegg kegg NA NA no no no no no dn Estrogen signaling pathway Pertussis 0 -0.498023715 0 kegg kegg NA NA no no no no no dn Ether lipid metabolism Pertussis -0.593913043 -0.618577075 -0.615701416 kegg kegg NA NA no no no no no dn Fanconi anemia pathway Pertussis 0 -0.57312253 -0.611583012 kegg kegg NA NA no no no no no dn Fat digestion and absorption Pertussis 0.607826087 0.764822134 0.432947233 yes kegg kegg NA NA no up up no no dn Fatty acid biosynthesis Pertussis 0.586086957 0.726284585 0.547232947 kegg kegg NA NA no no no no no dn Fatty acid degradation Pertussis 0.553043478 0.593873518 0 kegg kegg NA NA no no no no no dn Fatty acid metabolism Pertussis 0.58173913 0.695652174 0 kegg kegg NA NA no no no no no dn Fc epsilon RI signaling pathway Pertussis 0 0.759881423 0.405662806 kegg kegg NA NA no no no no no dn Fc gamma R-mediated phagocytosis Pertussis 0.750434783 0.903162055 0.867953668 kegg kegg NA NA no no no no no dn Folate biosynthesis Pertussis 0 -0.482213439 0 kegg kegg NA NA no no no no no dn GABAergic synapse Pertussis 0.522608696 0.52173913 0.599485199 kegg kegg NA NA no up up no no dn Galactose metabolism Pertussis 0 0.48715415 0 kegg kegg NA NA no no no no no dn Glucagon signaling pathway Pertussis -0.502608696 -0.900197628 -0.635263835 kegg kegg NA NA no no no no no dn Glutathione metabolism Pertussis 0 -0.605731225 0 kegg kegg NA NA no no no no no dn Glycerolipid metabolism Pertussis 0 0 -0.504247104 kegg kegg NA NA no no up no no dn Glycerophospholipid metabolism Pertussis 0 0 -0.595881596 kegg kegg NA NA no no up no no dn "Glycine, serine and threonine metabolism" Pertussis 0 -0.583003953 0 kegg kegg NA NA no up no no no dn Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Pertussis 0.471304348 0.420948617 0 kegg kegg NA NA no no no no no dn Glycosaminoglycan biosynthesis - heparan sulfate / heparin Pertussis 0 -0.448616601 0 kegg kegg NA NA no no no no no dn Glycosaminoglycan biosynthesis - keratan sulfate Pertussis -0.45826087 -0.473320158 0 kegg kegg NA NA no no no no no dn Glycosaminoglycan degradation Pertussis 0.48 0.73715415 0 kegg kegg NA NA no no up no no dn Glycosphingolipid biosynthesis - ganglio series Pertussis 0 0 -0.418790219 kegg kegg NA NA no no no no no dn Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Pertussis 0 -0.570158103 -0.449420849 kegg kegg NA NA no no no no no dn Glyoxylate and dicarboxylate metabolism Pertussis 0.506956522 0.755928854 0.682882883 kegg kegg NA NA no no no no no dn GnRH signaling pathway Pertussis 0 -0.705533597 0 kegg kegg NA NA no no no no no dn Hedgehog signaling pathway Pertussis -0.435652174 -0.639328063 -0.640669241 kegg kegg NA NA no no no no no dn Hippo signaling pathway - multiple species Pertussis 0 0.608695652 0 kegg kegg NA NA no no no no no dn Homologous recombination Pertussis 0 0 -0.574774775 kegg kegg NA NA no no no no no dn Huntington disease Pertussis -0.494782609 -0.686758893 -0.457142857 kegg kegg NA NA no no no no no dn IL-17 signaling pathway Pertussis 0.575652174 0.894268775 0.74980695 kegg kegg NA NA no no no no no dn Inflammatory mediator regulation of TRP channels Pertussis 0 -0.740118577 0 kegg kegg NA NA no no no no no dn Inositol phosphate metabolism Pertussis 0 0 -0.534877735 kegg kegg NA NA no no no no no dn Insulin secretion Pertussis -0.573913043 -0.787549407 0 yes kegg kegg NA NA no up up no no dn Insulin signaling pathway Pertussis -0.527826087 -0.563241107 -0.518146718 kegg kegg NA NA no no no no no dn Leukocyte transendothelial migration Pertussis 0 0 0.589189189 kegg kegg NA NA no no no no no dn Linoleic acid metabolism Pertussis 0 -0.425889328 0 kegg kegg NA NA no no no no no dn Longevity regulating pathway Pertussis -0.416521739 0 0 kegg kegg NA NA no no no no no dn Lysine degradation Pertussis -0.573913043 -0.589920949 -0.718661519 kegg kegg NA NA no no no no no dn Lysosome Pertussis 0.547826087 0.889328063 0.688288288 kegg kegg NA NA no no no no no dn Mannose type O-glycan biosynthesis Pertussis -0.553043478 -0.53458498 -0.706821107 kegg kegg NA NA no no no no no dn Melanogenesis Pertussis -0.499130435 -0.759881423 0 kegg kegg NA NA no no no no no dn Mineral absorption Pertussis -0.420869565 -0.427865613 0 kegg kegg NA NA no no no no no dn Mismatch repair Pertussis 0 -0.486166008 0 kegg kegg NA NA no no no no no dn Mitophagy - animal Pertussis -0.590434783 -0.603754941 0 kegg kegg NA NA no no no no no dn Morphine addiction Pertussis 0 -0.64229249 0 kegg kegg NA NA no up up no no dn mRNA surveillance pathway Pertussis -0.574782609 -0.826086957 -0.823938224 kegg kegg NA NA no no no no no dn mTOR signaling pathway Pertussis -0.564347826 -0.54743083 -0.437065637 kegg kegg NA NA no no no no no dn N-Glycan biosynthesis Pertussis -0.474782609 -0.749011858 -0.562676963 kegg kegg NA NA no no no no no dn Natural killer cell mediated cytotoxicity Pertussis 0.583478261 0.701581028 0.412097812 kegg kegg NA NA no no no no no dn Neuroactive ligand-receptor interaction Pertussis 0.609565217 0.863636364 0.771171171 kegg kegg NA NA up up up no no dn Neurotrophin signaling pathway Pertussis 0 0.43083004 0 kegg kegg NA NA no no no no no dn Neutrophil extracellular trap formation Pertussis 0.705217391 0.882411067 0.829343629 kegg kegg NA NA no no no no no dn NF-kappa B signaling pathway Pertussis 0 0.493083004 0 kegg kegg NA NA no no no no no dn Nicotinate and nicotinamide metabolism Pertussis 0.624347826 0.781620553 0.650707851 kegg kegg NA NA no no no no no dn Nicotine addiction Pertussis 0 -0.494071146 0 kegg kegg NA NA no up up no no dn Nitrogen metabolism Pertussis 0.527826087 0.644268775 0.617760618 kegg kegg NA NA no no no no no dn NOD-like receptor signaling pathway Pertussis 0.672173913 0.730237154 0.564993565 kegg kegg NA NA no no no no no dn Non-alcoholic fatty liver disease Pertussis -0.466956522 -0.626482213 -0.465637066 kegg kegg NA NA no no no no no dn Notch signaling pathway Pertussis 0 0 -0.402316602 kegg kegg NA NA no no no no no dn Nucleotide excision repair Pertussis 0 -0.638339921 -0.635778636 kegg kegg NA NA no no no no no dn Olfactory transduction Pertussis 0.548695652 0.837944664 0.696010296 kegg kegg NA NA no no no no no dn One carbon pool by folate Pertussis 0 -0.670948617 -0.652252252 kegg kegg NA NA no no no no no dn Oocyte meiosis Pertussis 0 0 -0.426769627 kegg kegg NA NA no no no no no dn Osteoclast differentiation Pertussis 0.545217391 0.866600791 0.787644788 kegg kegg NA NA no no no no no dn Other types of O-glycan biosynthesis Pertussis -0.660869565 -0.648221344 -0.663835264 kegg kegg NA NA no no no no no dn Ovarian steroidogenesis Pertussis 0 -0.424901186 0 kegg kegg NA NA no up up no no dn Oxidative phosphorylation Pertussis -0.433913043 -0.64229249 -0.415444015 kegg kegg NA NA no no no no no dn Oxytocin signaling pathway Pertussis 0 0 0.446846847 kegg kegg NA NA no no no no no dn p53 signaling pathway Pertussis -0.42173913 0 -0.567567568 kegg kegg NA NA no no no no no dn Pancreatic secretion Pertussis 0 -0.643280632 0 kegg kegg NA NA no no no no no dn Pantothenate and CoA biosynthesis Pertussis 0.65826087 0.816205534 0.554954955 kegg kegg NA NA no no dn no no dn "Parathyroid hormone synthesis, secretion and action" Pertussis -0.493913043 -0.591897233 0 kegg kegg NA NA no no no no no dn Parkinson disease Pertussis -0.592173913 -0.640316206 0 kegg kegg NA NA no no no no no dn Pathogenic Escherichia coli infection Pertussis 0.664347826 0.790513834 0.617760618 kegg kegg NA NA no no no no no dn Pathways of neurodegeneration - multiple diseases Pertussis -0.599130435 -0.665019763 0 kegg kegg NA NA no no no no no dn Pentose and glucuronate interconversions Pertussis 0 -0.593873518 -0.415701416 kegg kegg NA NA no no no no no dn Pentose phosphate pathway Pertussis 0.586086957 0.915019763 0.742342342 kegg kegg NA NA no no no no no dn Peroxisome Pertussis 0.552173913 0.759881423 0.543886744 kegg kegg NA NA no no no no no dn Phagosome Pertussis 0.568695652 0.809288538 0.674388674 kegg kegg NA NA no no no no no dn Phosphatidylinositol signaling system Pertussis -0.453913043 -0.5256917 -0.662805663 kegg kegg NA NA no no no no no dn PI3K-Akt signaling pathway Pertussis 0 0 -0.491119691 yes kegg kegg NA NA no up up no no dn Platinum drug resistance Pertussis 0 0 -0.432689833 kegg kegg NA NA no no no no no dn Porphyrin and chlorophyll metabolism Pertussis 0 -0.511857708 0 kegg kegg NA NA no no no no no dn PPAR signaling pathway Pertussis 0.585217391 0.750988142 0.681081081 kegg kegg NA NA no no no no no dn Prion disease Pertussis 0 -0.639328063 0 kegg kegg NA NA no no no no no dn Progesterone-mediated oocyte maturation Pertussis 0 0 -0.43989704 kegg kegg NA NA no no no no no dn Prolactin signaling pathway Pertussis 0 0.59486166 0 kegg kegg NA NA no no no no no dn Propanoate metabolism Pertussis 0 0 -0.489317889 kegg kegg NA NA no no no no no dn Protein digestion and absorption Pertussis 0 0.670948617 0 yes kegg kegg NA NA no up up no no dn Protein export Pertussis -0.466956522 -0.535573123 -0.633719434 kegg kegg NA NA no no no no no dn Protein processing in endoplasmic reticulum Pertussis -0.469565217 -0.774703557 0 kegg kegg NA NA no no no no no dn Proximal tubule bicarbonate reclamation Pertussis 0 -0.638339921 0 kegg kegg NA NA no no no no no dn Purine metabolism Pertussis 0 -0.632411067 0 kegg kegg NA NA no no no no no dn Pyrimidine metabolism Pertussis 0 -0.553359684 0 kegg kegg NA NA no no no no no dn Pyruvate metabolism Pertussis 0 -0.555335968 -0.428828829 kegg kegg NA NA no no no no no dn Ras signaling pathway Pertussis 0 -0.537549407 -0.557528958 yes kegg kegg NA NA no up up no no dn Regulation of lipolysis in adipocytes Pertussis 0 -0.494071146 0 kegg kegg NA NA no no no no no dn Renin secretion Pertussis 0 -0.614624506 0 kegg kegg NA NA no no no no no dn Renin-angiotensin system Pertussis 0.613913043 0.915019763 0.613127413 kegg kegg NA NA no no no no no dn Retrograde endocannabinoid signaling Pertussis 0 -0.583003953 0 kegg kegg NA NA no no up no no dn Ribosome Pertussis -0.743478261 -0.598814229 -0.458687259 kegg kegg NA NA no no no no no dn Ribosome biogenesis in eukaryotes Pertussis -0.511304348 -0.758893281 -0.720978121 kegg kegg NA NA no no no no no dn RIG-I-like receptor signaling pathway Pertussis 0 0.51284585 0 kegg kegg NA NA no no no no no dn RNA degradation Pertussis -0.529565217 -0.803359684 -0.718918919 kegg kegg NA NA no no no no no dn RNA polymerase Pertussis -0.47826087 -0.852766798 -0.713513514 kegg kegg NA NA no no no no no dn RNA transport Pertussis 0 -0.464426877 0 kegg kegg NA NA no no no no no dn Salmonella infection Pertussis 0.692173913 0.754940711 0.583783784 kegg kegg NA NA no no no no no dn Selenocompound metabolism Pertussis 0 0 -0.553410553 kegg kegg NA NA no no no no no dn Serotonergic synapse Pertussis 0 0 0.467953668 kegg kegg NA NA no no no no no dn Shigellosis Pertussis -0.437391304 -0.419960474 0 kegg kegg NA NA no no no no no dn Signaling pathways regulating pluripotency of stem cells Pertussis -0.486086957 -0.414031621 -0.45045045 kegg kegg NA NA no no no no no dn Sphingolipid signaling pathway Pertussis 0 0.57312253 0 kegg kegg NA NA no no no no no dn Spinocerebellar ataxia Pertussis 0 -0.684782609 -0.551093951 kegg kegg NA NA no no no no no dn Spliceosome Pertussis 0 -0.422924901 -0.6002574 kegg kegg NA NA no no no no no dn Starch and sucrose metabolism Pertussis 0.493913043 0.7243083 0 kegg kegg NA NA no no no no no dn Steroid biosynthesis Pertussis 0 0 -0.439382239 kegg kegg NA NA no no no no no dn Synaptic vesicle cycle Pertussis 0 0.890316206 0.454568855 kegg kegg NA NA no up up no no dn Synthesis and degradation of ketone bodies Pertussis 0 -0.51284585 -0.412097812 kegg kegg NA NA no no no no no dn Taste transduction Pertussis 0 -0.608695652 -0.666924067 kegg kegg NA NA no no up no no dn Taurine and hypotaurine metabolism Pertussis -0.411304348 0 -0.487001287 kegg kegg NA NA no no no no no dn Terpenoid backbone biosynthesis Pertussis 0 0 -0.448391248 kegg kegg NA NA no no no no no dn TGF-beta signaling pathway Pertussis -0.529565217 -0.455533597 -0.445302445 kegg kegg NA NA no no no no no dn Thermogenesis Pertussis -0.546086957 -0.696640316 -0.462805663 kegg kegg NA NA no no no no no dn Thiamine metabolism Pertussis 0 -0.466403162 0 kegg kegg NA NA no no no no no dn Thyroid hormone synthesis Pertussis -0.47826087 -0.677865613 0 kegg kegg NA NA no no no no no dn TNF signaling pathway Pertussis 0 0.422924901 0 kegg kegg NA NA no no no no no dn Toll-like receptor signaling pathway Pertussis 0 0.725296443 0.54002574 yes kegg kegg NA NA no no no no no dn Type I diabetes mellitus Pertussis 0 0.648221344 0 kegg kegg NA NA no no no no no dn Tyrosine metabolism Pertussis 0 -0.453557312 0 kegg kegg NA NA no no no no no dn Ubiquinone and other terpenoid-quinone biosynthesis Pertussis 0 -0.414031621 -0.577348777 kegg kegg NA NA no no no no no dn Ubiquitin mediated proteolysis Pertussis -0.670434783 -0.710474308 0 kegg kegg NA NA no no no no no dn "Valine, leucine and isoleucine degradation" Pertussis 0 -0.446640316 0 kegg kegg NA NA no no no no no dn Various types of N-glycan biosynthesis Pertussis 0 -0.616600791 0 kegg kegg NA NA no no no no no dn Vascular smooth muscle contraction Pertussis -0.435652174 -0.480237154 0 kegg kegg NA NA no no no no no dn Vasopressin-regulated water reabsorption Pertussis -0.423478261 -0.691699605 0 kegg kegg NA NA no no no no no dn Viral protein interaction with cytokine and cytokine receptor Pertussis 0.406086957 0.483201581 0 kegg kegg NA NA no no no no no dn Wnt signaling pathway Pertussis -0.56 -0.842885375 -0.683655084 kegg kegg NA NA no no no no no dn Eggerthella ph2 0 0.414265972 0 Genus Genus 0.912 0.269 no no no no no no Finegoldia ph2 0 0.501743098 0 Genus Genus 0.456 0.269 no no no no no no alpha-Linolenic acid metabolism Phagosome 0.437391304 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Phagosome 0 -0.415019763 0 kegg kegg NA NA no no no no no no Antifolate resistance Phagosome 0 -0.431818182 -0.511454311 kegg kegg NA NA no no no no no no Arginine and proline metabolism Phagosome 0 0.432806324 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Phagosome 0 0.420948617 0 kegg kegg NA NA no no no no no no Autophagy - other Phagosome -0.675652174 0 -0.590733591 kegg kegg NA NA no no no no no no Basal transcription factors Phagosome -0.75826087 -0.723320158 -0.813127413 kegg kegg NA NA no no no no no no Base excision repair Phagosome -0.46 -0.633399209 -0.635263835 kegg kegg NA NA no no no no no no beta-Alanine metabolism Phagosome 0.425217391 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Phagosome 0.744347826 0.787549407 0.717374517 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Phagosome 0 -0.808300395 0 kegg kegg NA NA no no no no no no Butyricicoccus Phagosome 0 0 0.439461115 butyrate-producing Genus kegg 0.852 NA no no no no no no cAMP signaling pathway Phagosome -0.467826087 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Phagosome 0.568695652 0.635375494 0.602574003 kegg kegg NA NA no no no no no no Cell cycle Phagosome -0.716521739 -0.747035573 -0.642728443 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Phagosome 0 0.73715415 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Phagosome 0 0.622529644 0.619305019 kegg kegg NA NA no no no no no no DNA replication Phagosome -0.456521739 -0.51284585 -0.583783784 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Phagosome -0.46173913 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Phagosome 0 -0.602766798 0 kegg kegg NA NA no no no no no no Endocytosis Phagosome 0.892173913 0.936758893 0.79047619 kegg kegg NA NA no no no no no no Ether lipid metabolism Phagosome -0.627826087 -0.79743083 -0.59021879 kegg kegg NA NA no no no no no no Eubacterium Phagosome 0 0 -0.406343288 Genus kegg 0.0692 NA no no no no no no Fanconi anemia pathway Phagosome -0.487826087 -0.661067194 -0.674388674 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Phagosome 0 0.466403162 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Phagosome 0.405217391 0 0 kegg kegg NA NA no no no no no no Folate biosynthesis Phagosome -0.43826087 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Phagosome 0 0 -0.46023166 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Phagosome 0.409565217 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Phagosome 0.428695652 0.43083004 0 kegg kegg NA NA no no no no no no Glutathione metabolism Phagosome 0 -0.556324111 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Phagosome -0.54173913 -0.508893281 -0.587387387 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Phagosome 0 -0.718379447 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Phagosome 0.46173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Phagosome 0 0 -0.454054054 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Phagosome 0 0.604743083 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Phagosome -0.411304348 -0.761857708 -0.476190476 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Phagosome 0 0.46541502 0 kegg kegg NA NA no no no no no no Homologous recombination Phagosome 0 -0.579051383 -0.725868726 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Phagosome 0 0 -0.544658945 kegg kegg NA NA no no no no no no Lysine degradation Phagosome -0.435652174 -0.58201581 -0.621879022 kegg kegg NA NA no no no no no no Lysosome Phagosome 0.466956522 0.851778656 0.520720721 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Phagosome 0 -0.43972332 -0.53024453 kegg kegg NA NA no no no no no no Mismatch repair Phagosome 0 -0.51284585 0 kegg kegg NA NA no no no no no no Mitophagy - animal Phagosome 0 -0.557312253 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Phagosome -0.779130435 -0.66798419 -0.676190476 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Phagosome -0.56 -0.531620553 -0.468211068 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Phagosome 0 0.800395257 0.488288288 kegg kegg NA NA up up up no no no Nicotinate and nicotinamide metabolism Phagosome 0 0.533596838 0.413899614 kegg kegg NA NA no no no no no no Nitrogen metabolism Phagosome 0.52 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Phagosome -0.46 -0.640316206 -0.674903475 kegg kegg NA NA no no no no no no One carbon pool by folate Phagosome -0.455652174 -0.612648221 -0.501415701 kegg kegg NA NA no no no no no no Oocyte meiosis Phagosome -0.662608696 0 -0.452767053 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Phagosome -0.693913043 -0.695652174 -0.720978121 kegg kegg NA NA no no no no no no Oxidative phosphorylation Phagosome -0.557391304 -0.418972332 0 kegg kegg NA NA no no no no no no p53 signaling pathway Phagosome -0.625217391 -0.578063241 -0.767310167 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Phagosome 0 0.511857708 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Phagosome 0 -0.434782609 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Phagosome 0.699130435 0.876482213 0.557271557 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Phagosome -0.605217391 -0.481225296 -0.667953668 kegg kegg NA NA no no no no no no Platinum drug resistance Phagosome -0.42173913 -0.444664032 -0.691634492 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Phagosome 0 -0.693675889 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Phagosome 0 0.572134387 0.560617761 kegg kegg NA NA no no no no no no Protein export Phagosome -0.812173913 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Phagosome -0.442608696 -0.656126482 0 kegg kegg NA NA no no no no no no Purine metabolism Phagosome 0 -0.761857708 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Phagosome 0 -0.494071146 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Phagosome 0.507826087 0 0.52998713 kegg kegg NA NA no no no no no no Ras signaling pathway Phagosome 0 0 -0.563449163 yes kegg kegg NA NA no up up no no no Ribosome Phagosome -0.626086957 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Phagosome -0.66173913 -0.683794466 -0.653796654 kegg kegg NA NA no no no no no no RNA degradation Phagosome -0.734782609 -0.566205534 -0.524324324 kegg kegg NA NA no no no no no no RNA polymerase Phagosome -0.697391304 -0.735177866 -0.635006435 kegg kegg NA NA no no no no no no Ruminococcus Phagosome 0 0 0.468211068 acetate-producing Genus kegg 0.335 NA no no no no no no Selenocompound metabolism Phagosome -0.623478261 -0.591897233 -0.643758044 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Phagosome 0 0.68972332 0 kegg kegg NA NA no no no no no no Spliceosome Phagosome -0.56 -0.511857708 -0.640926641 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Phagosome 0 0.462450593 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Phagosome -0.704347826 0 -0.418275418 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Phagosome 0 -0.559288538 -0.523552124 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Phagosome -0.440869565 0 -0.42033462 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Phagosome -0.753913043 0 -0.512226512 kegg kegg NA NA no no no no no no Thiamine metabolism Phagosome 0 -0.479249012 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Phagosome 0 -0.438735178 -0.537194337 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Phagosome -0.413913043 -0.666007905 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Phagosome -0.526086957 0 0 kegg kegg NA NA no no no no no no 2-hydroxyhippuric acid+urine Phenaceturic acid+urine -0.514285714 0 0 urine_cometabolism urine_cometabolism 0.215 0.737 no no no no no no DL-Indole-3-lactic acid+urine Phenaceturic acid+urine 0 0.461403509 0 urine_cometabolism urine_cometabolism 0.00552 0.737 up up no no no no Homovanillic acid+urine Phenaceturic acid+urine -0.536842105 0 0 urine_cometabolism urine_cometabolism 0.45 0.737 no no no no no no L-Phenylalanine+urine Phenaceturic acid+urine 0 -0.457894737 0 urine_cometabolism urine_cometabolism 0.0908 0.737 no up no no no no 4-hydroxybenzoic acid+stool Phenylacetic acid+stool 0 0 -0.62055336 stool_cometabolism stool_cometabolism 0.0536 0.785 no dn no no no no Acetic acid+stool Phenylacetic acid+stool -0.469556244 0 -0.60770751 yes stool_scfa stool_cometabolism 0.0656 0.785 dn no no no no no Alistipes Phenylacetic acid+stool 0.480869694 0 0 Genus stool_cometabolism 0.0114 0.785 no up no no no no Allograft rejection Phenylacetic acid+stool 0 0 -0.491812535 kegg stool_cometabolism NA 0.785 no no no no no no Autoimmune thyroid disease Phenylacetic acid+stool 0 0 -0.491812535 kegg stool_cometabolism NA 0.785 no no no no no no Butyric acid+stool Phenylacetic acid+stool 0 0 -0.447628458 yes stool_scfa stool_cometabolism 0.102 0.785 dn no no no no no Butyricicoccus Phenylacetic acid+stool 0 0 -0.426403016 butyrate-producing Genus stool_cometabolism 0.852 0.785 no no no no no no CA+stool Phenylacetic acid+stool 0 0 -0.475296443 stool_bileacids stool_cometabolism 0.827 0.785 no no no no no no Caproic acid+stool Phenylacetic acid+stool 0 0.622377622 0 stool_scfa stool_cometabolism 0.882 0.785 no no no no no no CDCA+stool Phenylacetic acid+stool 0 -0.692307692 -0.677865613 stool_bileacids stool_cometabolism 0.663 0.785 no no no no no no Cell adhesion molecules Phenylacetic acid+stool 0 0 -0.516657256 kegg stool_cometabolism NA 0.785 no no no no no no Cellular senescence Phenylacetic acid+stool 0 0 -0.462450593 kegg stool_cometabolism NA 0.785 no no no no no no Central carbon metabolism in cancer Phenylacetic acid+stool -0.523219814 0 0 kegg stool_cometabolism NA 0.785 no no no no no no Coprococcus Phenylacetic acid+stool -0.620227038 0 0 butyrate-producing Genus stool_cometabolism 0.612 0.785 no no no no no no Endocytosis Phenylacetic acid+stool 0 0 -0.464709204 kegg stool_cometabolism NA 0.785 no no no no no no Faecalibacterium Phenylacetic acid+stool 0 -0.671328671 -0.460929998 butyrate-producing Genus stool_cometabolism 0.0039 0.785 no dn dn no no no GCDCA+stool Phenylacetic acid+stool 0 -0.93006993 0 yes stool_bileacids stool_cometabolism 0.0471 0.785 no dn no no no no GDCA+stool Phenylacetic acid+stool 0 -0.59895013 0 stool_bileacids stool_cometabolism 0.656 0.785 no no no no no no Graft-versus-host disease Phenylacetic acid+stool 0 0 -0.497459063 kegg stool_cometabolism NA 0.785 no no no no no no GUDCA+stool Phenylacetic acid+stool 0.518098316 0 0 yes stool_bileacids stool_cometabolism 0.0085 0.785 no dn no no no no Indole-3-Acetic acid+stool Phenylacetic acid+stool 0.711042312 0.741258741 0.693675889 stool_cometabolism stool_cometabolism 0.304 0.785 no no no no no no Intestinal immune network for IgA production Phenylacetic acid+stool 0 -0.618181818 0 kegg stool_cometabolism NA 0.785 no no no no no no iso-LCA+stool Phenylacetic acid+stool 0 0 0.449604743 stool_bileacids stool_cometabolism 0.72 0.785 no no no no no no Isobutyric acid+stool Phenylacetic acid+stool 0.849329205 0.881118881 0.860671937 stool_scfa stool_cometabolism 0.408 0.785 no no no no no no Isovaleric acid+stool Phenylacetic acid+stool 0.791537668 0.951048951 0.881422925 stool_scfa stool_cometabolism 0.343 0.785 no no no no no no L-Phenylalanine+stool Phenylacetic acid+stool 0.486068111 0.685314685 0.670948617 stool_cometabolism stool_cometabolism 0.398 0.785 no no no no no no L-Tryptophan+stool Phenylacetic acid+stool 0.574819401 0 0.716403162 stool_cometabolism stool_cometabolism 0.557 0.785 no no no no no no L-Tyrosine+stool Phenylacetic acid+stool 0 0 0.57312253 stool_cometabolism stool_cometabolism 0.44 0.785 no no no no no no Legionellosis Phenylacetic acid+stool -0.525283798 0 0 kegg stool_cometabolism NA 0.785 no no no no no no nutriCA+stool Phenylacetic acid+stool 0 0 -0.504940711 stool_bileacids stool_cometabolism 0.481 0.785 no no no no no no Parabacteroides Phenylacetic acid+stool 0 0.629370629 0 Genus stool_cometabolism 4.19E-05 0.785 no up up no no no Pathways in cancer Phenylacetic acid+stool 0 0 0.473743648 kegg stool_cometabolism NA 0.785 no no no no no no PI3K-Akt signaling pathway Phenylacetic acid+stool -0.471620227 0 0 yes kegg stool_cometabolism NA 0.785 no up up no no no Primary immunodeficiency Phenylacetic acid+stool -0.533539732 0 0 kegg stool_cometabolism NA 0.785 no no no no no no Roseburia Phenylacetic acid+stool 0 -0.858144924 0 butyrate-producing Genus stool_cometabolism 0.495 0.785 no no no no no no Type I diabetes mellitus Phenylacetic acid+stool 0 0 -0.501976285 kegg stool_cometabolism NA 0.785 no no no no no no Viral myocarditis Phenylacetic acid+stool 0 0 -0.492941841 kegg stool_cometabolism NA 0.785 no no no no no no 12-HEPE+blood Phenylacetyl L-GlutaMine+urine 0 0 0.481393452 serum_ARA urine_cometabolism 0.312 0.0909 no no no up no no "12,13-EPOME+blood" Phenylacetyl L-GlutaMine+urine 0 0 0.435445287 serum_ARA urine_cometabolism 0.901 0.0909 no no no up no no 13-HODE+blood Phenylacetyl L-GlutaMine+urine 0 0.565934066 0 serum_ARA urine_cometabolism 0.32 0.0909 no no no up no no 15-HETE+blood Phenylacetyl L-GlutaMine+urine 0 0 -0.4640622 serum_ARA urine_cometabolism 0.819 0.0909 no no no up no no 16:0/18:1-PC+blood Phenylacetyl L-GlutaMine+urine 0.50245098 0.648351648 0 serum_phospholipids urine_cometabolism 6.15E-07 0.0909 up up up up no no 16:0/18:2-PC+blood Phenylacetyl L-GlutaMine+urine 0.490196078 0.686813187 0 serum_phospholipids urine_cometabolism 3.24E-06 0.0909 no up up up no no 16:0/20:4-PI+blood Phenylacetyl L-GlutaMine+urine -0.605392157 0 0 serum_phospholipids urine_cometabolism 0.558 0.0909 no no no up no no 16:1/18:2-PG+blood Phenylacetyl L-GlutaMine+urine 0.507352941 0 0 serum_phospholipids urine_cometabolism 1.40E-08 0.0909 no up up up no no 18:0-LPC+blood Phenylacetyl L-GlutaMine+urine 0 -0.71978022 0 serum_phospholipids urine_cometabolism 0.554 0.0909 no no no up no no 18:0-LPE+blood Phenylacetyl L-GlutaMine+urine 0 0 -0.433766234 serum_phospholipids urine_cometabolism 0.491 0.0909 no no no up no no 18:0/16:0-PC+blood Phenylacetyl L-GlutaMine+urine 0 0.604395604 0 serum_phospholipids urine_cometabolism 9.64E-07 0.0909 up up up up no no 18:0/18:1-PE+blood Phenylacetyl L-GlutaMine+urine 0 -0.554945055 0 serum_phospholipids urine_cometabolism 0.00716 0.0909 up up no up no no 18:0/18:2-PC+blood Phenylacetyl L-GlutaMine+urine 0.512254902 0 0 serum_phospholipids urine_cometabolism 1.74E-06 0.0909 no up up up no no 18:1-LPE+blood Phenylacetyl L-GlutaMine+urine 0 0 -0.515584416 serum_phospholipids urine_cometabolism 0.117 0.0909 no no no up no no 18:1/16:0-PC+blood Phenylacetyl L-GlutaMine+urine 0.490196078 0.67032967 0 serum_phospholipids urine_cometabolism 2.43E-05 0.0909 no up up up no no 18:1/18:0-PC+blood Phenylacetyl L-GlutaMine+urine 0.492647059 0 0 serum_phospholipids urine_cometabolism 1.83E-06 0.0909 no up up up no no 18:2n6c+blood Phenylacetyl L-GlutaMine+urine 0 0 0.451948052 serum_fattyacid urine_cometabolism 0.15 0.0909 no no no up no no 18:3n3+blood Phenylacetyl L-GlutaMine+urine 0 0 0.497402597 serum_fattyacid urine_cometabolism 0.291 0.0909 no no no up no no 18:3n6+blood Phenylacetyl L-GlutaMine+urine -0.534313725 -0.686813187 -0.477922078 serum_fattyacid urine_cometabolism 0.0463 0.0909 up no dn up no no 2-hydroxyphenylacetic acid+urine Phenylacetyl L-GlutaMine+urine -0.446616541 0 0 urine_cometabolism urine_cometabolism 0.763 0.0909 no no no up no no 20:3n6+blood Phenylacetyl L-GlutaMine+urine -0.50245098 0 0 serum_fattyacid urine_cometabolism 0.0884 0.0909 up no no up no no 4-hydroxybenzoic acid+stool Phenylacetyl L-GlutaMine+urine 0 0 -0.574819401 stool_cometabolism urine_cometabolism 0.0536 0.0909 no dn no up no no 8-HETE+blood Phenylacetyl L-GlutaMine+urine 0 0.642857143 0 serum_ARA urine_cometabolism 0.741 0.0909 no no no up no no 9-HODE+blood Phenylacetyl L-GlutaMine+urine 0 0.714285714 0 serum_ARA urine_cometabolism 0.297 0.0909 no no no up no no Adherens junction Phenylacetyl L-GlutaMine+urine 0.663157895 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no Adrenergic signaling in cardiomyocytes Phenylacetyl L-GlutaMine+urine 0 0 -0.426153846 kegg urine_cometabolism NA 0.0909 no no up up no no Alistipes Phenylacetyl L-GlutaMine+urine 0.557229548 0 0 Genus urine_cometabolism 0.0114 0.0909 no up no up no no Alzheimer disease Phenylacetyl L-GlutaMine+urine 0 -0.494736842 0 kegg urine_cometabolism NA 0.0909 no no no up no no Amoebiasis Phenylacetyl L-GlutaMine+urine 0 0.459649123 0 kegg urine_cometabolism NA 0.0909 no no no up no no Apelin signaling pathway Phenylacetyl L-GlutaMine+urine 0 -0.684210526 0 kegg urine_cometabolism NA 0.0909 no no no up no no Arrhythmogenic right ventricular cardiomyopathy Phenylacetyl L-GlutaMine+urine 0.598245614 0 0 kegg urine_cometabolism NA 0.0909 no up up up no no Autophagy - animal Phenylacetyl L-GlutaMine+urine -0.542105263 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no Bacterial invasion of epithelial cells Phenylacetyl L-GlutaMine+urine 0.521052632 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no CA+blood Phenylacetyl L-GlutaMine+urine 0 -0.762036484 0 serum_bileacids urine_cometabolism 0.606 0.0909 no no no up no no CDCA+blood Phenylacetyl L-GlutaMine+urine 0 -0.648351648 0 serum_bileacids urine_cometabolism 0.506 0.0909 no no no up no no CDCA+stool Phenylacetyl L-GlutaMine+urine 0 0 -0.488132095 stool_bileacids urine_cometabolism 0.663 0.0909 no no no up no no Central carbon metabolism in cancer Phenylacetyl L-GlutaMine+urine 0 -0.496491228 0 kegg urine_cometabolism NA 0.0909 no no no up no no Cholinergic synapse Phenylacetyl L-GlutaMine+urine -0.514035088 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no Coprococcus Phenylacetyl L-GlutaMine+urine -0.476691729 0 0 butyrate-producing Genus urine_cometabolism 0.612 0.0909 no no no up no no Coronavirus disease - COVID-19 Phenylacetyl L-GlutaMine+urine 0 -0.568421053 0 kegg urine_cometabolism NA 0.0909 no no no up no no d18:1-16:1-SM+blood Phenylacetyl L-GlutaMine+urine 0 -0.582417582 0 serum_phospholipids urine_cometabolism 0.2 0.0909 no no no up no no d18:1-18:1-SM+blood Phenylacetyl L-GlutaMine+urine 0 0 -0.471428571 serum_phospholipids urine_cometabolism 0.916 0.0909 no no no up no no DHA+blood Phenylacetyl L-GlutaMine+urine 0 0.576923077 0 serum_ARA urine_cometabolism 0.872 0.0909 no no no up no no Diabetic cardiomyopathy Phenylacetyl L-GlutaMine+urine 0 -0.528070175 0 kegg urine_cometabolism NA 0.0909 no no no up no no Dilated cardiomyopathy Phenylacetyl L-GlutaMine+urine 0.589473684 0 0 kegg urine_cometabolism NA 0.0909 no up up up no no DPA+blood Phenylacetyl L-GlutaMine+urine 0 0.774725275 0 serum_ARA urine_cometabolism 0.519 0.0909 no no no up no no EGFR tyrosine kinase inhibitor resistance Phenylacetyl L-GlutaMine+urine 0 -0.750877193 0 kegg urine_cometabolism NA 0.0909 no no no up no no Ethanolamine+blood Phenylacetyl L-GlutaMine+urine 0.590686275 0.741758242 0 serum_aminoacids urine_cometabolism 0.122 0.0909 up no no up no no Faecalibacterium Phenylacetyl L-GlutaMine+urine -0.448120301 0 -0.4054055 butyrate-producing Genus urine_cometabolism 0.0039 0.0909 no dn dn up no no Focal adhesion Phenylacetyl L-GlutaMine+urine 0.635087719 0 0 kegg urine_cometabolism NA 0.0909 no up up up no no FoxO signaling pathway Phenylacetyl L-GlutaMine+urine 0 0 0.424615385 kegg urine_cometabolism NA 0.0909 no no no up no no GABAergic synapse Phenylacetyl L-GlutaMine+urine -0.557894737 0 0 kegg urine_cometabolism NA 0.0909 no up up up no no Gastric acid secretion Phenylacetyl L-GlutaMine+urine 0.547368421 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no GCA+blood Phenylacetyl L-GlutaMine+urine 0 -0.703296703 0 yes serum_bileacids urine_cometabolism 0.16 0.0909 no no no up no no GCDCA+blood Phenylacetyl L-GlutaMine+urine 0 -0.615384615 0 serum_bileacids urine_cometabolism 0.31 0.0909 no no no up no no GDCA+blood Phenylacetyl L-GlutaMine+urine 0 0 0.54025974 serum_bileacids urine_cometabolism 0.632 0.0909 no no no up no no Glutamatergic synapse Phenylacetyl L-GlutaMine+urine 0 0.478947368 0 kegg urine_cometabolism NA 0.0909 no up up up no no Glutathione metabolism Phenylacetyl L-GlutaMine+urine 0 -0.49122807 0 kegg urine_cometabolism NA 0.0909 no no no up no no Glycolysis / Gluconeogenesis Phenylacetyl L-GlutaMine+urine 0 -0.498245614 0 kegg urine_cometabolism NA 0.0909 no no no up no no HCA+blood Phenylacetyl L-GlutaMine+urine 0 -0.672584793 0 serum_bileacids urine_cometabolism 0.544 0.0909 no no no up no no Hepatocellular carcinoma Phenylacetyl L-GlutaMine+urine 0.670175439 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no HIF-1 signaling pathway Phenylacetyl L-GlutaMine+urine 0 -0.735087719 0 kegg urine_cometabolism NA 0.0909 no no no up no no Hippo signaling pathway Phenylacetyl L-GlutaMine+urine 0.705263158 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no Hippuric acid+urine Phenylacetyl L-GlutaMine+urine 0 0 0.443418803 urine_cometabolism urine_cometabolism 0.361 0.0909 no no no up no no Homovanillic acid+urine Phenylacetyl L-GlutaMine+urine -0.718796992 0 -0.504957265 urine_cometabolism urine_cometabolism 0.45 0.0909 no no no up no no Human papillomavirus infection Phenylacetyl L-GlutaMine+urine 0 0.485964912 0 kegg urine_cometabolism NA 0.0909 no no no up no no Hypertrophic cardiomyopathy Phenylacetyl L-GlutaMine+urine 0.550877193 0 0 kegg urine_cometabolism NA 0.0909 no up up up no no Indole-3-Acetic acid+urine Phenylacetyl L-GlutaMine+urine 0 0.563157895 0 urine_cometabolism urine_cometabolism 0.657 0.0909 no no no up no no Influenza A Phenylacetyl L-GlutaMine+urine 0.703508772 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no Insulin signaling pathway Phenylacetyl L-GlutaMine+urine 0 -0.757894737 0 kegg urine_cometabolism NA 0.0909 no no no up no no iso-LCA+blood Phenylacetyl L-GlutaMine+urine 0 0 0.44882074 serum_bileacids urine_cometabolism 0.507 0.0909 no no no up no no iso-LCA+stool Phenylacetyl L-GlutaMine+urine 0 0 0.591331269 stool_bileacids urine_cometabolism 0.72 0.0909 no no no up no no JAK-STAT signaling pathway Phenylacetyl L-GlutaMine+urine 0 0.50877193 0.449230769 kegg urine_cometabolism NA 0.0909 no no no up no no L-Phenylalanine+stool Phenylacetyl L-GlutaMine+urine 0.63956044 0 0.5500516 stool_cometabolism urine_cometabolism 0.398 0.0909 no no no up no no L-Phenylalanine+urine Phenylacetyl L-GlutaMine+urine 0 -0.484210526 0 urine_cometabolism urine_cometabolism 0.0908 0.0909 no up no up no no L-Tryptophan+blood Phenylacetyl L-GlutaMine+urine 0 0 0.441558442 serum_aminoacids urine_cometabolism 0.164 0.0909 no no no up no no L-Tryptophan+stool Phenylacetyl L-GlutaMine+urine 0.714285714 0 0 stool_cometabolism urine_cometabolism 0.557 0.0909 no no no up no no L-Tyrosine+stool Phenylacetyl L-GlutaMine+urine 0.674725275 0 0.494324045 stool_cometabolism urine_cometabolism 0.44 0.0909 no no no up no no LCA+blood Phenylacetyl L-GlutaMine+urine 0 0 0.660407016 serum_bileacids urine_cometabolism 0.884 0.0909 no no no up no no Legionellosis Phenylacetyl L-GlutaMine+urine 0 -0.521052632 0 kegg urine_cometabolism NA 0.0909 no no no up no no Leishmaniasis Phenylacetyl L-GlutaMine+urine 0 -0.484210526 0 kegg urine_cometabolism NA 0.0909 no no no up no no Leukocyte transendothelial migration Phenylacetyl L-GlutaMine+urine 0.475438596 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no Long-term potentiation Phenylacetyl L-GlutaMine+urine 0 -0.542105263 0 kegg urine_cometabolism NA 0.0909 no no up up no no mTOR signaling pathway Phenylacetyl L-GlutaMine+urine 0 -0.79122807 0 kegg urine_cometabolism NA 0.0909 no no no up no no n3+blood Phenylacetyl L-GlutaMine+urine 0 0 0.588311688 serum_fattyacid urine_cometabolism 0.806 0.0909 no no no up no no Nicotinamide+urine Phenylacetyl L-GlutaMine+urine 0 0 -0.448888889 urine_cometabolism urine_cometabolism 0.721 0.0909 no no no up no no Non-small cell lung cancer Phenylacetyl L-GlutaMine+urine 0 0.459649123 0 kegg urine_cometabolism NA 0.0909 no no no up no no nutriCA+blood Phenylacetyl L-GlutaMine+urine 0 -0.583853171 0 serum_bileacids urine_cometabolism 0.726 0.0909 no no no up no no nutriCA+stool Phenylacetyl L-GlutaMine+urine 0 0 -0.607843137 stool_bileacids urine_cometabolism 0.481 0.0909 no no no up no no Oocyte meiosis Phenylacetyl L-GlutaMine+urine 0 -0.536842105 0 kegg urine_cometabolism NA 0.0909 no no no up no no Oscillospira Phenylacetyl L-GlutaMine+urine 0 0 0.540512821 LPS-producing Genus urine_cometabolism 0.62 0.0909 no no no up no no Oxidative phosphorylation Phenylacetyl L-GlutaMine+urine 0 -0.503508772 0 kegg urine_cometabolism NA 0.0909 no no no up no no Oxytocin signaling pathway Phenylacetyl L-GlutaMine+urine 0.503508772 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no Parabacteroides Phenylacetyl L-GlutaMine+urine 0.481203008 0 0 Genus urine_cometabolism 4.19E-05 0.0909 no up up up no no "Parathyroid hormone synthesis, secretion and action" Phenylacetyl L-GlutaMine+urine 0 -0.540350877 0 kegg urine_cometabolism NA 0.0909 no no no up no no Phenaceturic acid+urine Phenylacetyl L-GlutaMine+urine 0.667669173 0.561403509 0 urine_cometabolism urine_cometabolism 0.737 0.0909 no no no up no no Phenylacetic acid+stool Phenylacetyl L-GlutaMine+urine 0.582417582 0 0.713106295 stool_cometabolism urine_cometabolism 0.785 0.0909 no no no up no no Phospholipase D signaling pathway Phenylacetyl L-GlutaMine+urine 0 0.587719298 0 kegg urine_cometabolism NA 0.0909 no up up up no no PI3K-Akt signaling pathway Phenylacetyl L-GlutaMine+urine 0 -0.471929825 0 yes kegg urine_cometabolism NA 0.0909 no up up up no no Platelet activation Phenylacetyl L-GlutaMine+urine 0.501754386 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no Prion disease Phenylacetyl L-GlutaMine+urine 0 -0.549122807 0 kegg urine_cometabolism NA 0.0909 no no no up no no Proteoglycans in cancer Phenylacetyl L-GlutaMine+urine 0 -0.556140351 0 kegg urine_cometabolism NA 0.0909 no no no up no no PUFA%+blood Phenylacetyl L-GlutaMine+urine 0 0.604395604 0 serum_fattyacid urine_cometabolism 0.0013 0.0909 dn no up up no no Rap1 signaling pathway Phenylacetyl L-GlutaMine+urine 0.505263158 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no Renal cell carcinoma Phenylacetyl L-GlutaMine+urine 0 -0.463157895 0 kegg urine_cometabolism NA 0.0909 no no no up no no Retrograde endocannabinoid signaling Phenylacetyl L-GlutaMine+urine 0 -0.456140351 0 kegg urine_cometabolism NA 0.0909 no no up up no no Ribosome Phenylacetyl L-GlutaMine+urine 0 -0.563157895 0 kegg urine_cometabolism NA 0.0909 no no no up no no RNA degradation Phenylacetyl L-GlutaMine+urine 0 -0.473684211 0 kegg urine_cometabolism NA 0.0909 no no no up no no RNA transport Phenylacetyl L-GlutaMine+urine 0 -0.726315789 0 kegg urine_cometabolism NA 0.0909 no no no up no no Sarcosine+blood Phenylacetyl L-GlutaMine+urine 0 0 -0.518181818 serum_choline urine_cometabolism 5.06E-05 0.0909 up up no up no no Serine+blood Phenylacetyl L-GlutaMine+urine 0 0.593406593 0 serum_aminoacids urine_cometabolism 0.942 0.0909 no no no up no no SFA%+blood Phenylacetyl L-GlutaMine+urine 0 0.571428571 0 serum_fattyacid urine_cometabolism 0.0236 0.0909 no up no up no no Spinocerebellar ataxia Phenylacetyl L-GlutaMine+urine -0.587719298 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no Staphylococcus aureus infection Phenylacetyl L-GlutaMine+urine 0.603508772 0 0 kegg urine_cometabolism NA 0.0909 up no no up no no Taurine+blood Phenylacetyl L-GlutaMine+urine 0.558823529 0.631868132 0 serum_aminoacids urine_cometabolism 0.857 0.0909 no no no up no no TDCA+blood Phenylacetyl L-GlutaMine+urine 0 0 0.526108192 yes serum_bileacids urine_cometabolism 0.155 0.0909 no up no up no no Thermogenesis Phenylacetyl L-GlutaMine+urine 0 -0.473684211 0 kegg urine_cometabolism NA 0.0909 no no no up no no Thyroid hormone signaling pathway Phenylacetyl L-GlutaMine+urine 0.712280702 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no TMAO+blood Phenylacetyl L-GlutaMine+urine 0 0 0.57012987 serum_choline urine_cometabolism 0.00706 0.0909 up up no up no no Transcriptional misregulation in cancer Phenylacetyl L-GlutaMine+urine -0.496491228 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no UDCA+stool Phenylacetyl L-GlutaMine+urine 0 0 -0.622291022 stool_bileacids urine_cometabolism 0.266 0.0909 no no no up no no UFA%+blood Phenylacetyl L-GlutaMine+urine 0 0.56043956 0 serum_fattyacid urine_cometabolism 0.0236 0.0909 no dn no up no no Valine+blood Phenylacetyl L-GlutaMine+urine 0 0 0.515584416 yes serum_aminoacids urine_cometabolism 1.22E-06 0.0909 up up no up no no Vibrio cholerae infection Phenylacetyl L-GlutaMine+urine 0.545614035 0 0 kegg urine_cometabolism NA 0.0909 no no no up no no "Alanine, aspartate and glutamate metabolism" Phenylalanine metabolism 0 -0.583992095 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Phenylalanine metabolism 0 -0.564229249 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Phenylalanine metabolism 0 -0.596837945 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Phenylalanine metabolism 0.52 0.679841897 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Phenylalanine metabolism 0.705217391 0.856719368 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Phenylalanine metabolism 0 0.710474308 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Phenylalanine metabolism 0 -0.519762846 0 kegg kegg NA NA no no no no no no Fatty acid elongation Phenylalanine metabolism 0.602608696 0.614624506 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Phenylalanine metabolism 0.513043478 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Phenylalanine metabolism 0.548695652 0 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Phenylalanine metabolism 0.446086957 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Phenylalanine metabolism 0.664347826 0.692687747 0 kegg kegg NA NA no no no no no no Histidine metabolism Phenylalanine metabolism 0.535652174 0 0.6 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Phenylalanine metabolism 0.685217391 0.81027668 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Phenylalanine metabolism 0.551304348 0.626482213 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Phenylalanine metabolism 0.450434783 0.685770751 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Phenylalanine metabolism 0 0.670948617 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Phenylalanine metabolism 0.482608696 0.792490119 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Phenylalanine metabolism 0.416521739 0.666996047 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Phenylalanine metabolism 0.806086957 0.863636364 0.541055341 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Phenylalanine metabolism 0.630434783 0.830039526 0.41956242 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Phenylalanine metabolism 0.657391304 0.882411067 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Phosphatidylinositol signaling system -0.446086957 0 0 kegg kegg NA NA no no no no no no ABC transporters Phosphatidylinositol signaling system 0 0.510869565 0.475418275 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" Phosphatidylinositol signaling system 0 0 -0.474131274 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Phosphatidylinositol signaling system -0.733913043 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Phosphatidylinositol signaling system -0.637391304 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Phosphatidylinositol signaling system 0 0.5256917 0.438095238 kegg kegg NA NA no no no no no no Antifolate resistance Phosphatidylinositol signaling system 0 0.57312253 0.557014157 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Phosphatidylinositol signaling system 0 -0.434782609 -0.578635779 kegg kegg NA NA no no no no no no Arginine and proline metabolism Phosphatidylinositol signaling system -0.486956522 -0.451581028 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Phosphatidylinositol signaling system 0 0 -0.62007722 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Phosphatidylinositol signaling system 0 0 0.457142857 kegg kegg NA NA no no no no no no Basal transcription factors Phosphatidylinositol signaling system 0.531304348 0.729249012 0.753925354 kegg kegg NA NA no no no no no no Base excision repair Phosphatidylinositol signaling system 0 0.704545455 0.506821107 kegg kegg NA NA no no no no no no beta-Alanine metabolism Phosphatidylinositol signaling system -0.612173913 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Phosphatidylinositol signaling system -0.773913043 -0.519762846 -0.78043758 kegg kegg NA NA no no no no no no Butanoate metabolism Phosphatidylinositol signaling system -0.444347826 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Phosphatidylinositol signaling system 0.769565217 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Phosphatidylinositol signaling system 0.56 -0.464426877 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Phosphatidylinositol signaling system -0.706956522 0 -0.565250965 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Phosphatidylinositol signaling system 0 -0.497035573 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Phosphatidylinositol signaling system 0 -0.589920949 -0.483655084 kegg kegg NA NA no no no no no no Collinsella Phosphatidylinositol signaling system 0 0 -0.405263721 Genus kegg 0.128 NA no no no no no no DNA replication Phosphatidylinositol signaling system 0 0.570158103 0.574517375 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Phosphatidylinositol signaling system -0.566956522 0 0 kegg kegg NA NA no no no no no no Eggerthella Phosphatidylinositol signaling system 0 0.494773936 0 Genus kegg 0.912 NA no no no no no no Endocrine resistance Phosphatidylinositol signaling system 0.513043478 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Phosphatidylinositol signaling system 0.607826087 0 0.698069498 kegg kegg NA NA no no no no no no Ether lipid metabolism Phosphatidylinositol signaling system 0.528695652 0.507905138 0.642213642 kegg kegg NA NA no no no no no no Fanconi anemia pathway Phosphatidylinositol signaling system 0 0.685770751 0.731274131 kegg kegg NA NA no no no no no no Fatty acid elongation Phosphatidylinositol signaling system -0.417391304 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Phosphatidylinositol signaling system -0.473913043 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Phosphatidylinositol signaling system 0 0 0.423423423 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Phosphatidylinositol signaling system -0.742608696 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Phosphatidylinositol signaling system -0.636521739 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Phosphatidylinositol signaling system 0 0 -0.532561133 kegg kegg NA NA no no no no no no Glycerolipid metabolism Phosphatidylinositol signaling system 0 0 0.740540541 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Phosphatidylinositol signaling system 0 0.446640316 0.873873874 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Phosphatidylinositol signaling system -0.672173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Phosphatidylinositol signaling system 0 0.458498024 0.546460746 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Phosphatidylinositol signaling system 0.544347826 0 0.54002574 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Phosphatidylinositol signaling system 0 0.5 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Phosphatidylinositol signaling system 0.536521739 0 0.487773488 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Phosphatidylinositol signaling system 0 0.436758893 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Phosphatidylinositol signaling system 0 -0.416007905 -0.610810811 kegg kegg NA NA no no no no no no Homologous recombination Phosphatidylinositol signaling system 0 0.56916996 0.62033462 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Phosphatidylinositol signaling system 0 0.62055336 0.832432432 kegg kegg NA NA no no no no no no Linoleic acid metabolism Phosphatidylinositol signaling system -0.447826087 0 0 kegg kegg NA NA no no no no no no Lysine degradation Phosphatidylinositol signaling system 0 0.596837945 0.87979408 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Phosphatidylinositol signaling system 0.553913043 0.483201581 0.858944659 kegg kegg NA NA no no no no no no MAPK signaling pathway Phosphatidylinositol signaling system 0 0 0.558558559 kegg kegg NA NA no no no no no no Mismatch repair Phosphatidylinositol signaling system 0 0.473320158 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Phosphatidylinositol signaling system 0.764347826 0.449604743 0.857915058 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Phosphatidylinositol signaling system 0 0.490118577 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Phosphatidylinositol signaling system 0.608695652 0.532608696 0.677992278 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Phosphatidylinositol signaling system 0 0 -0.454568855 kegg kegg NA NA no no no no no no Nitrogen metabolism Phosphatidylinositol signaling system -0.482608696 -0.446640316 -0.563449163 kegg kegg NA NA no no no no no no Non-homologous end-joining Phosphatidylinositol signaling system -0.411304348 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Phosphatidylinositol signaling system 0 0.634387352 0.509395109 kegg kegg NA NA no no no no no no One carbon pool by folate Phosphatidylinositol signaling system 0 0.664031621 0.652767053 kegg kegg NA NA no no no no no no Other glycan degradation Phosphatidylinositol signaling system -0.42 0 0.576833977 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Phosphatidylinositol signaling system 0.545217391 0.682806324 0.923552124 kegg kegg NA NA no no no no no no Oxidative phosphorylation Phosphatidylinositol signaling system 0.513913043 0 0 kegg kegg NA NA no no no no no no Parabacteroides Phosphatidylinositol signaling system -0.450434783 0 0 Genus kegg 4.19E-05 NA no up up no no no Pentose and glucuronate interconversions Phosphatidylinositol signaling system 0 0.422924901 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Phosphatidylinositol signaling system -0.67826087 -0.463438735 -0.647361647 kegg kegg NA NA no no no no no no Phenylalanine metabolism Phosphatidylinositol signaling system -0.434782609 0 0 kegg kegg NA NA no no no no no no Platinum drug resistance Phosphatidylinositol signaling system 0.472173913 0.698616601 0.62985843 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Phosphatidylinositol signaling system 0 0 -0.429086229 kegg kegg NA NA no no no no no no PPAR signaling pathway Phosphatidylinositol signaling system -0.417391304 0 -0.534105534 kegg kegg NA NA no no no no no no Protein export Phosphatidylinositol signaling system 0.68 0 0.600514801 kegg kegg NA NA no no no no no no Pyrimidine metabolism Phosphatidylinositol signaling system -0.467826087 0.462450593 0 kegg kegg NA NA no no no no no no Ras signaling pathway Phosphatidylinositol signaling system 0.56173913 0 0.772458172 yes kegg kegg NA NA no up up no no no Retinol metabolism Phosphatidylinositol signaling system -0.410434783 0.509881423 0 kegg kegg NA NA no no no no no no Ribosome Phosphatidylinositol signaling system 0.523478261 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Phosphatidylinositol signaling system 0.506086957 0.75 0.812870013 kegg kegg NA NA no no no no no no RNA degradation Phosphatidylinositol signaling system 0.792173913 0.41798419 0.828571429 kegg kegg NA NA no no no no no no RNA polymerase Phosphatidylinositol signaling system 0.506956522 0.651185771 0.57014157 kegg kegg NA NA no no no no no no Selenocompound metabolism Phosphatidylinositol signaling system 0 0.701581028 0.740540541 kegg kegg NA NA no no no no no no Spliceosome Phosphatidylinositol signaling system 0 0.592885375 0.767567568 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Phosphatidylinositol signaling system -0.686956522 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Phosphatidylinositol signaling system 0.459130435 0.485177866 0.422651223 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Phosphatidylinositol signaling system 0 0 0.432432432 kegg kegg NA NA no no no no no no Sulfur metabolism Phosphatidylinositol signaling system 0 0 -0.555212355 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Phosphatidylinositol signaling system 0 0.693675889 0.526383526 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Phosphatidylinositol signaling system 0 0 0.501673102 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Phosphatidylinositol signaling system 0 0.541501976 0.642471042 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Phosphatidylinositol signaling system 0 0.492094862 0.436293436 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Phosphatidylinositol signaling system 0 0.442687747 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Phosphatidylinositol signaling system 0.483478261 0.595849802 0.619047619 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Phosphatidylinositol signaling system 0 -0.4743083 -0.496010296 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Phospholipase D signaling pathway 0 -0.612648221 -0.458172458 kegg kegg NA NA no no no no up up ABC transporters Phospholipase D signaling pathway 0 0.423913043 0 kegg kegg NA NA no up up no up up "Alanine, aspartate and glutamate metabolism" Phospholipase D signaling pathway 0 0.641304348 0 kegg kegg NA NA no no no no up up alpha-Linolenic acid metabolism Phospholipase D signaling pathway 0 0.495059289 0 kegg kegg NA NA no no no no up up Amino sugar and nucleotide sugar metabolism Phospholipase D signaling pathway -0.550434783 0 0 kegg kegg NA NA no no no no up up Aminoacyl-tRNA biosynthesis Phospholipase D signaling pathway -0.480869565 -0.471343874 -0.463835264 kegg kegg NA NA no no no no up up Arachidonic acid metabolism Phospholipase D signaling pathway -0.48 0 0 kegg kegg NA NA no no no no up up Arginine and proline metabolism Phospholipase D signaling pathway 0 0.644268775 0 kegg kegg NA NA no up no no up up Arginine biosynthesis Phospholipase D signaling pathway 0 0.632411067 0 kegg kegg NA NA no no no no up up Ascorbate and aldarate metabolism Phospholipase D signaling pathway 0 0 -0.438610039 kegg kegg NA NA no no no no up up Bacteroides Phospholipase D signaling pathway 0 -0.505928854 0 LPS-producing Genus kegg 0.000267 NA dn dn up no up up Base excision repair Phospholipase D signaling pathway -0.419130435 0 -0.453796654 kegg kegg NA NA no no no no up up beta-Alanine metabolism Phospholipase D signaling pathway 0 -0.584980237 -0.583783784 kegg kegg NA NA no no no no up up Biosynthesis of cofactors Phospholipase D signaling pathway -0.44 -0.454545455 0 kegg kegg NA NA no no no no up up Biosynthesis of unsaturated fatty acids Phospholipase D signaling pathway -0.436521739 -0.516798419 -0.471814672 kegg kegg NA NA no no no no up up Butanoate metabolism Phospholipase D signaling pathway -0.482608696 -0.848814229 -0.786872587 kegg kegg NA NA no no no no up up Butyricimonas Phospholipase D signaling pathway 0.473657229 0 0 butyrate-producing Genus kegg 0.17 NA no no no no up up Calcium signaling pathway Phospholipase D signaling pathway 0 0 0.406692407 kegg kegg NA NA no up up no up up cAMP signaling pathway Phospholipase D signaling pathway 0 0.650197628 0.555984556 yes kegg kegg NA NA no up up no up up Carbon metabolism Phospholipase D signaling pathway 0 -0.438735178 0 kegg kegg NA NA no no no no up up cGMP-PKG signaling pathway Phospholipase D signaling pathway 0 0.489130435 0 kegg kegg NA NA no no no no up up Chemokine signaling pathway Phospholipase D signaling pathway 0.58 0.523715415 0 kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) Phospholipase D signaling pathway -0.575652174 -0.877470356 -0.583011583 kegg kegg NA NA no no no no up up Clostridium Phospholipase D signaling pathway 0 -0.468650518 0 Genus kegg 0.925 NA no no no no up up Cysteine and methionine metabolism Phospholipase D signaling pathway -0.685217391 -0.941699605 -0.502702703 kegg kegg NA NA no no no no up up Cytokine-cytokine receptor interaction Phospholipase D signaling pathway 0.522608696 0 0 kegg kegg NA NA no no no no up up DNA replication Phospholipase D signaling pathway -0.573913043 -0.725296443 -0.562934363 kegg kegg NA NA no no no no up up Drug metabolism - cytochrome P450 Phospholipase D signaling pathway -0.732173913 -0.79743083 -0.446074646 kegg kegg NA NA no no no no up up Drug metabolism - other enzymes Phospholipase D signaling pathway -0.548695652 -0.825098814 -0.457400257 kegg kegg NA NA no no no no up up EGFR tyrosine kinase inhibitor resistance Phospholipase D signaling pathway 0 -0.744071146 -0.566280566 kegg kegg NA NA no no no no up up Endocrine resistance Phospholipase D signaling pathway 0.432173913 0 0.546718147 kegg kegg NA NA no no no no up up ErbB signaling pathway Phospholipase D signaling pathway 0.500869565 0.589920949 0 kegg kegg NA NA no no no no up up Ether lipid metabolism Phospholipase D signaling pathway 0 0 -0.400772201 kegg kegg NA NA no no no no up up Fanconi anemia pathway Phospholipase D signaling pathway -0.543478261 0 -0.498584299 kegg kegg NA NA no no no no up up Fatty acid biosynthesis Phospholipase D signaling pathway 0 0.639328063 0 kegg kegg NA NA no no no no up up Fatty acid elongation Phospholipase D signaling pathway 0 -0.652173913 -0.572715573 kegg kegg NA NA no no no no up up Folate biosynthesis Phospholipase D signaling pathway -0.608695652 -0.466403162 0 kegg kegg NA NA no no no no up up FoxO signaling pathway Phospholipase D signaling pathway 0 0.553359684 0 kegg kegg NA NA no no no no up up Fructose and mannose metabolism Phospholipase D signaling pathway 0 0.606719368 0 kegg kegg NA NA no no no no up up Galactose metabolism Phospholipase D signaling pathway 0 0.432806324 0 kegg kegg NA NA no no no no up up Glutathione metabolism Phospholipase D signaling pathway -0.500869565 -0.553359684 0 kegg kegg NA NA no no no no up up Glycerolipid metabolism Phospholipase D signaling pathway 0 0.559288538 0 kegg kegg NA NA no no up no up up Glycerophospholipid metabolism Phospholipase D signaling pathway 0 0.471343874 0 kegg kegg NA NA no no up no up up Glycolysis / Gluconeogenesis Phospholipase D signaling pathway -0.457391304 -0.901185771 -0.442471042 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Phospholipase D signaling pathway 0.486086957 0.882411067 0.482625483 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate Phospholipase D signaling pathway 0.457391304 0 0 kegg kegg NA NA no no no no up up Glycosphingolipid biosynthesis - lacto and neolacto series Phospholipase D signaling pathway 0.433043478 0.518774704 0 kegg kegg NA NA no no no no up up Glyoxylate and dicarboxylate metabolism Phospholipase D signaling pathway 0 0.596837945 0 kegg kegg NA NA no no no no up up HIF-1 signaling pathway Phospholipase D signaling pathway 0 -0.811264822 -0.528442728 kegg kegg NA NA no no no no up up Homologous recombination Phospholipase D signaling pathway -0.468695652 0 -0.512226512 kegg kegg NA NA no no no no up up Linoleic acid metabolism Phospholipase D signaling pathway -0.580869565 0 0 kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 Phospholipase D signaling pathway -0.693913043 -0.794466403 -0.414414414 kegg kegg NA NA no no no no up up Mismatch repair Phospholipase D signaling pathway -0.619130435 -0.711462451 -0.618790219 kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis Phospholipase D signaling pathway -0.573043478 0 0 kegg kegg NA NA no no no no up up N-Glycan biosynthesis Phospholipase D signaling pathway 0 -0.657114625 0 kegg kegg NA NA no no no no up up NF-kappa B signaling pathway Phospholipase D signaling pathway 0 0.785573123 0.416216216 kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Phospholipase D signaling pathway 0 0.741106719 0 kegg kegg NA NA no no no no up up Nitrogen metabolism Phospholipase D signaling pathway 0 0.632411067 0 kegg kegg NA NA no no no no up up Non-homologous end-joining Phospholipase D signaling pathway -0.448695652 -0.776679842 -0.524581725 kegg kegg NA NA no no no no up up Nucleotide excision repair Phospholipase D signaling pathway -0.613913043 -0.614624506 -0.571943372 kegg kegg NA NA no no no no up up Odoribacter Phospholipase D signaling pathway -0.498314732 0 0 butyrate-producing Genus kegg 0.798 NA no no no no up up One carbon pool by folate Phospholipase D signaling pathway -0.50173913 -0.531620553 -0.440669241 kegg kegg NA NA no no no no up up Other glycan degradation Phospholipase D signaling pathway 0 0.437747036 0 kegg kegg NA NA no no no no up up Oxidative phosphorylation Phospholipase D signaling pathway 0 -0.536561265 0 kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis Phospholipase D signaling pathway 0 0.532608696 0 kegg kegg NA NA no no dn no up up Pentose and glucuronate interconversions Phospholipase D signaling pathway -0.664347826 -0.808300395 -0.570656371 kegg kegg NA NA no no no no up up Phenylalanine metabolism Phospholipase D signaling pathway 0 -0.657114625 0 kegg kegg NA NA no no no no up up PPAR signaling pathway Phospholipase D signaling pathway 0 0.486166008 0 kegg kegg NA NA no no no no up up Prevotella Phospholipase D signaling pathway 0 0.427898299 0.440922165 acetate-producing Genus kegg 0.287 NA no no no no up up Primary bile acid biosynthesis Phospholipase D signaling pathway -0.610434783 -0.713438735 0 kegg kegg NA NA no no no no up up Propanoate metabolism Phospholipase D signaling pathway -0.659130435 -0.944664032 -0.527155727 kegg kegg NA NA no no no no up up Proteasome Phospholipase D signaling pathway 0 -0.860671937 -0.517889318 kegg kegg NA NA no no no no up up Protein export Phospholipase D signaling pathway 0 -0.783596838 0 kegg kegg NA NA no no no no up up Pyrimidine metabolism Phospholipase D signaling pathway -0.51826087 -0.5 0 kegg kegg NA NA no no no no up up Pyruvate metabolism Phospholipase D signaling pathway -0.639130435 -0.93972332 -0.58970399 kegg kegg NA NA no no no no up up Rap1 signaling pathway Phospholipase D signaling pathway 0 0 0.422908623 kegg kegg NA NA no no no no up up Ras signaling pathway Phospholipase D signaling pathway 0 -0.533596838 0 yes kegg kegg NA NA no up up no up up Retinol metabolism Phospholipase D signaling pathway -0.464347826 -0.428853755 -0.451737452 kegg kegg NA NA no no no no up up Ribosome Phospholipase D signaling pathway 0 -0.703557312 -0.493178893 kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes Phospholipase D signaling pathway 0 -0.489130435 -0.405920206 kegg kegg NA NA no no no no up up RNA degradation Phospholipase D signaling pathway 0 -0.636363636 0 kegg kegg NA NA no no no no up up RNA polymerase Phospholipase D signaling pathway 0 -0.597826087 -0.468468468 kegg kegg NA NA no no no no up up RNA transport Phospholipase D signaling pathway -0.524347826 -0.781620553 -0.468468468 kegg kegg NA NA no no no no up up Sphingolipid signaling pathway Phospholipase D signaling pathway 0.50173913 0 0 kegg kegg NA NA no no no no up up Starch and sucrose metabolism Phospholipase D signaling pathway 0 0.577075099 0 kegg kegg NA NA no no no no up up Steroid biosynthesis Phospholipase D signaling pathway 0 -0.652173913 0 kegg kegg NA NA no no no no up up Steroid hormone biosynthesis Phospholipase D signaling pathway -0.553043478 -0.557312253 0 kegg kegg NA NA no no no no up up Succinivibrio Phospholipase D signaling pathway 0 0 -0.411251532 Genus kegg 0.138 NA no no no no up up Synthesis and degradation of ketone bodies Phospholipase D signaling pathway -0.553043478 -0.631422925 -0.473101673 kegg kegg NA NA no no no no up up Taurine and hypotaurine metabolism Phospholipase D signaling pathway 0 0.639328063 0 kegg kegg NA NA no no no no up up Terpenoid backbone biosynthesis Phospholipase D signaling pathway 0 0 -0.43989704 kegg kegg NA NA no no no no up up Thiamine metabolism Phospholipase D signaling pathway -0.606086957 -0.789525692 0 kegg kegg NA NA no no no no up up Tryptophan metabolism Phospholipase D signaling pathway -0.511304348 -0.739130435 -0.615701416 kegg kegg NA NA no up no no up up Tyrosine metabolism Phospholipase D signaling pathway -0.479130435 -0.699604743 -0.526898327 kegg kegg NA NA no no no no up up Ubiquinone and other terpenoid-quinone biosynthesis Phospholipase D signaling pathway -0.640869565 -0.562252964 -0.483912484 kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" Phospholipase D signaling pathway -0.616521739 -0.696640316 -0.674903475 kegg kegg NA NA no no no no up up Various types of N-glycan biosynthesis Phospholipase D signaling pathway 0 -0.566205534 0 kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor Phospholipase D signaling pathway 0.446086957 0 0 kegg kegg NA NA no no no no up up ABC transporters Phototransduction -0.577391304 -0.675889328 0 kegg kegg NA NA no up up no no no Adherens junction Phototransduction 0 0.627470356 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Phototransduction 0.523478261 0 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Phototransduction -0.464347826 -0.520750988 -0.407464607 kegg kegg NA NA no no no no no no Antigen processing and presentation Phototransduction 0 0.581027668 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Phototransduction 0 0.64229249 0.402574003 kegg kegg NA NA no no no no no no Apoptosis Phototransduction 0 -0.460474308 -0.401544402 kegg kegg NA NA no no no no no no Apoptosis - multiple species Phototransduction 0 -0.551383399 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Phototransduction 0 -0.468379447 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Phototransduction -0.443478261 -0.460474308 -0.441956242 kegg kegg NA NA no no no no no no Autophagy - animal Phototransduction 0 -0.739130435 0 kegg kegg NA NA no no no no no no Autophagy - other Phototransduction 0 -0.530632411 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Phototransduction -0.43826087 -0.54743083 -0.501673102 kegg kegg NA NA no no no no no no Basal transcription factors Phototransduction 0 0 0.442471042 kegg kegg NA NA no no no no no no Base excision repair Phototransduction 0 0 0.462290862 kegg kegg NA NA no no no no no no beta-Alanine metabolism Phototransduction 0 0.634387352 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Phototransduction 0 0.603754941 0.571171171 kegg kegg NA NA no no no no no no Butanoate metabolism Phototransduction 0 0.628458498 0.542342342 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Phototransduction 0 -0.56027668 -0.488545689 kegg kegg NA NA no no no no no no cAMP signaling pathway Phototransduction 0 -0.454545455 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Phototransduction 0 0.588932806 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Phototransduction 0 0.464426877 0 kegg kegg NA NA no no up no no no Cell cycle Phototransduction 0 0 0.556756757 kegg kegg NA NA no no no no no no Circadian entrainment Phototransduction 0.649565217 0.532608696 0 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Phototransduction 0 0.711462451 0.437065637 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Phototransduction 0.419130435 0.720355731 0.522522523 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Phototransduction 0 -0.440711462 0 kegg kegg NA NA no no no no no no DNA replication Phototransduction 0 0.454545455 0.433462033 kegg kegg NA NA no no no no no no Dopaminergic synapse Phototransduction 0.469565217 0 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Phototransduction 0.447826087 0.624505929 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Phototransduction 0 0.719367589 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Phototransduction 0 0.497035573 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Phototransduction 0 -0.809288538 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Phototransduction 0 0 0.491634492 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Phototransduction 0 -0.498023715 -0.476705277 kegg kegg NA NA no no no no no no Fatty acid elongation Phototransduction 0 0.707509881 0.516859717 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Phototransduction 0 -0.540513834 -0.515572716 kegg kegg NA NA no no no no no no Focal adhesion Phototransduction 0 0.718379447 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Phototransduction 0 -0.665019763 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Phototransduction -0.409565217 -0.730237154 0 kegg kegg NA NA no no no no no no Galactose metabolism Phototransduction -0.432173913 -0.427865613 0 kegg kegg NA NA no no no no no no Gap junction Phototransduction 0 -0.468379447 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Phototransduction 0 -0.548418972 0 kegg kegg NA NA no up up no no no Glycerolipid metabolism Phototransduction -0.650434783 -0.747035573 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Phototransduction -0.432173913 -0.617588933 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Phototransduction 0 0.813241107 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Phototransduction -0.492173913 -0.87055336 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Phototransduction 0 -0.518774704 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Phototransduction -0.522608696 -0.43083004 -0.50965251 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Phototransduction 0 0.633399209 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Phototransduction 0 0.614624506 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Phototransduction 0 0.595849802 0 kegg kegg NA NA no no no no no no Homologous recombination Phototransduction 0 0 0.487516088 kegg kegg NA NA no no no no no no IL-17 signaling pathway Phototransduction 0 0 -0.56036036 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Phototransduction -0.451304348 -0.602766798 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Phototransduction 0 -0.82312253 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Phototransduction 0 0.56027668 0 kegg kegg NA NA no no no no no no Long-term potentiation Phototransduction 0.6 0.750988142 0.531531532 kegg kegg NA NA no no up no no no Longevity regulating pathway Phototransduction 0 -0.510869565 0 kegg kegg NA NA no no no no no no Lysine degradation Phototransduction 0 -0.469367589 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Phototransduction 0 -0.473320158 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Phototransduction 0.417391304 0.711462451 0 kegg kegg NA NA no no no no no no Mismatch repair Phototransduction 0 0.538537549 0.562934363 kegg kegg NA NA no no no no no no mTOR signaling pathway Phototransduction 0 0.496047431 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Phototransduction 0 -0.523715415 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Phototransduction -0.686956522 -0.777667984 -0.659202059 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Phototransduction 0 -0.468379447 -0.575289575 kegg kegg NA NA no no no no no no Nitrogen metabolism Phototransduction -0.470434783 -0.444664032 -0.422651223 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Phototransduction 0 -0.505928854 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Phototransduction 0 0.721343874 0 kegg kegg NA NA no no no no no no Notch signaling pathway Phototransduction 0 -0.711462451 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Phototransduction 0 0 0.543886744 kegg kegg NA NA no no no no no no One carbon pool by folate Phototransduction 0 0 0.441956242 kegg kegg NA NA no no no no no no Oocyte meiosis Phototransduction 0.713043478 0.836956522 0.765765766 kegg kegg NA NA no no no no no no Osteoclast differentiation Phototransduction 0 0 -0.611583012 kegg kegg NA NA no no no no no no Other glycan degradation Phototransduction -0.52173913 -0.601778656 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Phototransduction 0 -0.483201581 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Phototransduction 0 0.549407115 0.421106821 kegg kegg NA NA no no no no no no p53 signaling pathway Phototransduction 0 -0.574110672 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Phototransduction 0 0.609683794 0.562162162 kegg kegg NA NA no no no no no no Pentose phosphate pathway Phototransduction -0.42 0 -0.504761905 kegg kegg NA NA no no no no no no Peroxisome Phototransduction 0 0 -0.407979408 kegg kegg NA NA no no no no no no Phenylalanine metabolism Phototransduction 0 0.583003953 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Phototransduction 0 -0.788537549 -0.521492921 kegg kegg NA NA no up up no no no Platelet activation Phototransduction 0 0.580039526 0 kegg kegg NA NA no no no no no no Platinum drug resistance Phototransduction 0 -0.535573123 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Phototransduction 0 0 -0.478507079 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Phototransduction 0 0.81027668 0 kegg kegg NA NA no no no no no no Propanoate metabolism Phototransduction 0 0.732213439 0.448648649 kegg kegg NA NA no no no no no no Proteasome Phototransduction 0 0.806324111 0 kegg kegg NA NA no no no no no no Protein export Phototransduction 0.424347826 0.675889328 0.465122265 kegg kegg NA NA no no no no no no Pyruvate metabolism Phototransduction 0 0.690711462 0 kegg kegg NA NA no no no no no no Ras signaling pathway Phototransduction 0.525217391 0.506916996 0.511969112 yes kegg kegg NA NA no up up no no no Retrograde endocannabinoid signaling Phototransduction 0 0.631422925 0.476190476 kegg kegg NA NA no no up no no no Ribosome Phototransduction 0 0.587944664 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Phototransduction 0 0 0.511969112 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Phototransduction 0 -0.732213439 -0.555212355 kegg kegg NA NA no no no no no no RNA degradation Phototransduction 0 0 0.425482625 kegg kegg NA NA no no no no no no RNA transport Phototransduction 0 0.498023715 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Phototransduction 0 -0.613636364 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Phototransduction -0.465217391 -0.614624506 0 kegg kegg NA NA no no no no no no Spliceosome Phototransduction 0 -0.503952569 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Phototransduction 0 0.64229249 0.538481338 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Phototransduction 0 0.533596838 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Phototransduction 0 0.432806324 0.551351351 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Phototransduction 0 -0.551383399 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Phototransduction 0 -0.836956522 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Phototransduction 0 0 0.499356499 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Phototransduction 0.527826087 0.748023715 0.54980695 kegg kegg NA NA no no no no no no Thermogenesis Phototransduction 0 0.56916996 0.483655084 kegg kegg NA NA no no no no no no Thiamine metabolism Phototransduction 0 0.584980237 0 kegg kegg NA NA no no no no no no Tight junction Phototransduction 0 0.746047431 0 kegg kegg NA NA no no no no no no TNF signaling pathway Phototransduction 0 -0.757905138 -0.446074646 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Phototransduction 0 -0.567193676 -0.546975547 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Phototransduction 0 0.736166008 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Phototransduction 0 0.58201581 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Phototransduction 0 0.41798419 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Phototransduction 0 0.543478261 0.540797941 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Phototransduction 0.551304348 0.625494071 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Phototransduction 0 -0.662055336 0 kegg kegg NA NA no no no no no no ABC transporters PI3K-Akt signaling pathway 0.532173913 0 0 yes kegg kegg NA NA no up up no up up Aminoacyl-tRNA biosynthesis PI3K-Akt signaling pathway 0.423478261 0 0.411583012 yes kegg kegg NA NA no no no no up up Anaerostipes PI3K-Akt signaling pathway 0 0.438717149 0 butyrate-producing yes Genus kegg 0.568 NA no no no no up up Arachidonic acid metabolism PI3K-Akt signaling pathway 0 0 -0.5001287 yes kegg kegg NA NA no no no no up up Autophagy - animal PI3K-Akt signaling pathway 0.473913043 0 0 yes kegg kegg NA NA no no no no up up Autophagy - other PI3K-Akt signaling pathway 0.589565217 0 0.426769627 yes kegg kegg NA NA no no no no up up Basal transcription factors PI3K-Akt signaling pathway 0.446086957 0 0.611583012 yes kegg kegg NA NA no no no no up up Base excision repair PI3K-Akt signaling pathway 0.555652174 0 0.614929215 yes kegg kegg NA NA no no no no up up Butanoate metabolism PI3K-Akt signaling pathway 0 0 0.56962677 yes kegg kegg NA NA no no no no up up Cell cycle PI3K-Akt signaling pathway 0.614782609 0 0.507078507 yes kegg kegg NA NA no no no no up up Chemokine signaling pathway PI3K-Akt signaling pathway 0 0 -0.491119691 yes kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) PI3K-Akt signaling pathway 0 0 0.526640927 yes kegg kegg NA NA no no no no up up Cysteine and methionine metabolism PI3K-Akt signaling pathway 0.620869565 0 0.792020592 yes kegg kegg NA NA no no no no up up DNA replication PI3K-Akt signaling pathway 0.515652174 0 0.653281853 yes kegg kegg NA NA no no no no up up EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway 0.594782609 0.601778656 0.902702703 yes kegg kegg NA NA no no no no up up Fanconi anemia pathway PI3K-Akt signaling pathway 0.65826087 0 0.572972973 yes kegg kegg NA NA no no no no up up Folate biosynthesis PI3K-Akt signaling pathway 0.54173913 0 0 yes kegg kegg NA NA no no no no up up FoxO signaling pathway PI3K-Akt signaling pathway 0.434782609 0 0 yes kegg kegg NA NA no no no no up up Gemmiger PI3K-Akt signaling pathway 0 0.418397831 0 butyrate-producing yes Genus kegg 0.595 NA no no no no up up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PI3K-Akt signaling pathway 0.599130435 0 0 yes kegg kegg NA NA no no no no up up HIF-1 signaling pathway PI3K-Akt signaling pathway 0.596521739 0.564229249 0.832947233 yes kegg kegg NA NA no no no no up up Homologous recombination PI3K-Akt signaling pathway 0.685217391 0 0.578120978 yes kegg kegg NA NA no no no no up up Inositol phosphate metabolism PI3K-Akt signaling pathway 0.446086957 0 0 yes kegg kegg NA NA no no no no up up Lysine degradation PI3K-Akt signaling pathway 0.599130435 0 0 yes kegg kegg NA NA no no no no up up Lysosome PI3K-Akt signaling pathway -0.453043478 0 -0.432689833 yes kegg kegg NA NA no no no no up up MAPK signaling pathway PI3K-Akt signaling pathway 0.52173913 0 0 yes kegg kegg NA NA no no no no up up Mismatch repair PI3K-Akt signaling pathway 0 0 0.55958816 yes kegg kegg NA NA no no no no up up mRNA surveillance pathway PI3K-Akt signaling pathway 0 0 0.517374517 yes kegg kegg NA NA no no no no up up mTOR signaling pathway PI3K-Akt signaling pathway 0.611304348 0.59486166 0.857142857 yes kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis PI3K-Akt signaling pathway 0.5 0 0 yes kegg kegg NA NA no no no no up up N-Glycan biosynthesis PI3K-Akt signaling pathway 0 0 0.512483912 yes kegg kegg NA NA no no no no up up Nitrogen metabolism PI3K-Akt signaling pathway 0 0 -0.416731017 yes kegg kegg NA NA no no no no up up Non-homologous end-joining PI3K-Akt signaling pathway 0 0 0.433719434 yes kegg kegg NA NA no no no no up up Nucleotide excision repair PI3K-Akt signaling pathway 0.491304348 0 0.642728443 yes kegg kegg NA NA no no no no up up One carbon pool by folate PI3K-Akt signaling pathway 0.479130435 0 0.424195624 yes kegg kegg NA NA no no no no up up Oocyte meiosis PI3K-Akt signaling pathway 0 0 0.551866152 yes kegg kegg NA NA no no no no up up Other glycan degradation PI3K-Akt signaling pathway 0.474782609 0 0 yes kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis PI3K-Akt signaling pathway 0.556521739 0 0 yes kegg kegg NA NA no no no no up up p53 signaling pathway PI3K-Akt signaling pathway 0.474782609 0 0 yes kegg kegg NA NA no no no no up up Parabacteroides PI3K-Akt signaling pathway 0 0 -0.504279556 yes Genus kegg 4.19E-05 NA no up up no up up Pentose and glucuronate interconversions PI3K-Akt signaling pathway 0 0 0.45997426 yes kegg kegg NA NA no no no no up up Phagosome PI3K-Akt signaling pathway -0.507826087 0 0 yes kegg kegg NA NA no no no no up up Phospholipase D signaling pathway PI3K-Akt signaling pathway -0.466086957 0 -0.538738739 yes kegg kegg NA NA no up up no up up Platinum drug resistance PI3K-Akt signaling pathway 0.443478261 0 0 yes kegg kegg NA NA no no no no up up Propanoate metabolism PI3K-Akt signaling pathway 0.605217391 0.415019763 0.804375804 yes kegg kegg NA NA no no no no up up Protein export PI3K-Akt signaling pathway 0 0 0.647104247 yes kegg kegg NA NA no no no no up up Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway 0 0 0.538996139 yes kegg kegg NA NA no no no no up up Pyruvate metabolism PI3K-Akt signaling pathway 0.536521739 0 0.657400257 yes kegg kegg NA NA no no no no up up Rap1 signaling pathway PI3K-Akt signaling pathway -0.434782609 -0.459486166 -0.424453024 yes kegg kegg NA NA no no no no up up Retinol metabolism PI3K-Akt signaling pathway 0 0 0.40978121 yes kegg kegg NA NA no no no no up up Ribosome PI3K-Akt signaling pathway 0 0 0.620849421 yes kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes PI3K-Akt signaling pathway 0.563478261 0 0.613899614 yes kegg kegg NA NA no no no no up up RNA degradation PI3K-Akt signaling pathway 0 0 0.610810811 yes kegg kegg NA NA no no no no up up RNA polymerase PI3K-Akt signaling pathway 0.414782609 0 0.57966538 yes kegg kegg NA NA no no no no up up RNA transport PI3K-Akt signaling pathway 0.735652174 0.643280632 0.740797941 yes kegg kegg NA NA no no no no up up Selenocompound metabolism PI3K-Akt signaling pathway 0.567826087 0 0 yes kegg kegg NA NA no no no no up up SNARE interactions in vesicular transport PI3K-Akt signaling pathway 0.513043478 0 0 yes kegg kegg NA NA no no no no up up Sphingolipid metabolism PI3K-Akt signaling pathway -0.416521739 0 0 yes kegg kegg NA NA no no no no up up Spliceosome PI3K-Akt signaling pathway 0.733913043 0 0.644272844 yes kegg kegg NA NA no no no no up up Synthesis and degradation of ketone bodies PI3K-Akt signaling pathway 0.493043478 0 0.450707851 yes kegg kegg NA NA no no no no up up Terpenoid backbone biosynthesis PI3K-Akt signaling pathway 0.423478261 0 0.44041184 yes kegg kegg NA NA no no no no up up Thiamine metabolism PI3K-Akt signaling pathway 0.665217391 0 0 yes kegg kegg NA NA no no no no up up Tryptophan metabolism PI3K-Akt signaling pathway 0 0 0.488030888 yes kegg kegg NA NA no up no no up up Ubiquinone and other terpenoid-quinone biosynthesis PI3K-Akt signaling pathway 0 0 0.498069498 yes kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" PI3K-Akt signaling pathway 0 0 0.541570142 yes kegg kegg NA NA no no no no up up Various types of N-glycan biosynthesis PI3K-Akt signaling pathway 0.486956522 0 0.545173745 yes kegg kegg NA NA no no no no up up ABC transporters Platelet activation 0 -0.615612648 0 kegg kegg NA NA no up up no no no Adherens junction Platelet activation 0.922608696 0.936758893 0.86023166 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Platelet activation 0 -0.543478261 0 kegg kegg NA NA no no no no no no Alistipes Platelet activation 0 -0.428926526 0 Genus kegg 0.0114 NA no up no no no no Apelin signaling pathway Platelet activation -0.434782609 0 0 kegg kegg NA NA no no no no no no Apoptosis Platelet activation 0.415652174 0 0.506306306 kegg kegg NA NA no no no no no no Apoptosis - multiple species Platelet activation -0.673043478 -0.666996047 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Platelet activation 0 -0.428853755 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Platelet activation 0 -0.454545455 0 kegg kegg NA NA no no no no no no Autophagy - animal Platelet activation -0.742608696 -0.78458498 -0.482110682 kegg kegg NA NA no no no no no no Autophagy - other Platelet activation -0.843478261 -0.84486166 -0.556756757 kegg kegg NA NA no no no no no no Basal transcription factors Platelet activation -0.666956522 0 -0.508880309 kegg kegg NA NA no no no no no no Base excision repair Platelet activation -0.643478261 0 0 kegg kegg NA NA no no no no no no Butyricicoccus Platelet activation -0.446011794 0 0 butyrate-producing Genus kegg 0.852 NA no no no no no no Calcium signaling pathway Platelet activation 0 0.451581028 0 kegg kegg NA NA no up up no no no Carbon metabolism Platelet activation 0 0.43972332 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Platelet activation 0 0.541501976 0 kegg kegg NA NA no no up no no no Chemokine signaling pathway Platelet activation 0 0 0.5003861 kegg kegg NA NA no no no no no no Complement and coagulation cascades Platelet activation 0 0 0.506821107 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Platelet activation 0 0 0.652767053 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Platelet activation 0 0.481225296 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Platelet activation 0 0.602766798 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Platelet activation -0.535652174 0 -0.403088803 kegg kegg NA NA no no no no no no ErbB signaling pathway Platelet activation -0.455652174 -0.557312253 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Platelet activation 0 -0.447628458 0 kegg kegg NA NA no no no no no no Fatty acid degradation Platelet activation 0 -0.498023715 0 kegg kegg NA NA no no no no no no Focal adhesion Platelet activation 0.907826087 0.913043478 0.8 kegg kegg NA NA no up up no no no FoxO signaling pathway Platelet activation -0.435652174 -0.717391304 0 kegg kegg NA NA no no no no no no Gap junction Platelet activation 0.562608696 0 0.600772201 kegg kegg NA NA no no no no no no Glycerolipid metabolism Platelet activation 0 -0.604743083 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Platelet activation -0.542608696 -0.609683794 -0.417503218 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Platelet activation 0 0.476284585 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Platelet activation 0 -0.541501976 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Platelet activation 0.480869565 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Platelet activation 0.44173913 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Platelet activation 0 -0.464426877 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Platelet activation -0.591304348 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Platelet activation 0.883478261 0.827075099 0.790990991 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Platelet activation 0 -0.433794466 0 kegg kegg NA NA no no no no no no Homologous recombination Platelet activation 0 -0.58201581 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Platelet activation 0 -0.617588933 0 kegg kegg NA NA no no no no no no Lachnospira Platelet activation 0 0.597479633 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Longevity regulating pathway Platelet activation 0 -0.483201581 0 kegg kegg NA NA no no no no no no Lysine degradation Platelet activation -0.626956522 -0.458498024 -0.445817246 kegg kegg NA NA no no no no no no MAPK signaling pathway Platelet activation 0 -0.66798419 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Platelet activation 0 0.542490119 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Platelet activation -0.442608696 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Platelet activation -0.492173913 0 -0.467953668 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Platelet activation 0 -0.658102767 -0.437323037 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Platelet activation -0.586086957 -0.661067194 -0.416731017 kegg kegg NA NA no no no no no no Nitrogen metabolism Platelet activation 0 -0.440711462 0 kegg kegg NA NA no no no no no no Oscillospira Platelet activation 0 -0.427865613 0 LPS-producing Genus kegg 0.62 NA no no no no no no Other glycan degradation Platelet activation 0 -0.52173913 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Platelet activation -0.593913043 -0.47826087 -0.446074646 kegg kegg NA NA no no no no no no Oxidative phosphorylation Platelet activation 0 0.564229249 0.415444015 kegg kegg NA NA no no no no no no p53 signaling pathway Platelet activation -0.75826087 -0.708498024 -0.559330759 kegg kegg NA NA no no no no no no Peroxisome Platelet activation 0 -0.466403162 0 kegg kegg NA NA no no no no no no Phagosome Platelet activation 0.406086957 0 0.461776062 kegg kegg NA NA no no no no no no Phenylalanine metabolism Platelet activation 0.613913043 0.540513834 0.428056628 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Platelet activation -0.482608696 0 0 yes kegg kegg NA NA no up up no no no Platinum drug resistance Platelet activation -0.702608696 -0.645256917 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Platelet activation 0 -0.466403162 0 kegg kegg NA NA no no no no no no Proteasome Platelet activation -0.520869565 0 0 kegg kegg NA NA no no no no no no Protein export Platelet activation -0.479130435 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Platelet activation 0 0 -0.522522523 kegg kegg NA NA no no no no no no Rap1 signaling pathway Platelet activation 0.896521739 0.933794466 0.953925354 kegg kegg NA NA no no no no no no Ras signaling pathway Platelet activation 0 0.501976285 0 yes kegg kegg NA NA no up up no no no Ribosome biogenesis in eukaryotes Platelet activation -0.567826087 0 -0.406692407 kegg kegg NA NA no no no no no no RNA degradation Platelet activation -0.42 0 -0.421879022 kegg kegg NA NA no no no no no no RNA polymerase Platelet activation -0.628695652 0 0 kegg kegg NA NA no no no no no no RNA transport Platelet activation -0.426086957 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Platelet activation -0.705217391 -0.433794466 -0.44993565 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Platelet activation 0 -0.502964427 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Platelet activation -0.436521739 -0.683794466 0 kegg kegg NA NA no no no no no no Spliceosome Platelet activation -0.751304348 -0.718379447 -0.462805663 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Platelet activation -0.454782609 -0.59486166 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Platelet activation 0 0.437747036 0 kegg kegg NA NA no no no no no no Thiamine metabolism Platelet activation 0 0 -0.448906049 kegg kegg NA NA no no no no no no Tight junction Platelet activation 0.800869565 0.882411067 0.638352638 kegg kegg NA NA no no no no no no Tyrosine metabolism Platelet activation 0 0.421936759 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Platelet activation -0.420869565 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Platelet activation 0 0.694664032 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Platelet activation 0 0 0.583783784 kegg kegg NA NA no no no no no no Alistipes Platinum drug resistance 0 0.442299524 0 Genus kegg 0.0114 NA no up no no no no Amino sugar and nucleotide sugar metabolism Platinum drug resistance 0 0.57312253 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Platinum drug resistance 0.414782609 0.489130435 0.442728443 kegg kegg NA NA no no no no no no Antifolate resistance Platinum drug resistance 0 0.520750988 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Platinum drug resistance 0 0 -0.403861004 kegg kegg NA NA no no no no no no Carbon metabolism Platinum drug resistance 0 -0.4743083 0 kegg kegg NA NA no no no no no no Clostridium Platinum drug resistance 0 -0.41872905 0 Genus kegg 0.925 NA no no no no no no Cysteine and methionine metabolism Platinum drug resistance 0 0 0.431917632 kegg kegg NA NA no no no no no no Ether lipid metabolism Platinum drug resistance 0 0 0.432175032 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Platinum drug resistance 0 0.449604743 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Platinum drug resistance 0 0.786561265 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Platinum drug resistance 0.534782609 0.780632411 0.543629344 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Platinum drug resistance 0 -0.43972332 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Platinum drug resistance -0.67826087 0 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Platinum drug resistance 0 0.469367589 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Platinum drug resistance -0.563478261 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Platinum drug resistance 0.595652174 0.553359684 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Platinum drug resistance 0.406956522 0.855731225 0.672586873 kegg kegg NA NA no no no no no no Lachnospira Platinum drug resistance 0 -0.478379061 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Linoleic acid metabolism Platinum drug resistance -0.49826087 0 0 kegg kegg NA NA no no no no no no Lysine degradation Platinum drug resistance 0.459130435 0.795454545 0.541570142 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Platinum drug resistance 0 0.628458498 0.464864865 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Platinum drug resistance 0 0.646245059 0.497812098 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Platinum drug resistance 0.592173913 0 0.592020592 kegg kegg NA NA no no no no no no One carbon pool by folate Platinum drug resistance 0.515652174 0.431818182 0.466151866 kegg kegg NA NA no no no no no no Oscillospira Platinum drug resistance 0 0.549407115 0 LPS-producing Genus kegg 0.62 NA no no no no no no Other glycan degradation Platinum drug resistance 0 0.606719368 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Platinum drug resistance 0.523478261 0.837944664 0.734105534 kegg kegg NA NA no no no no no no Pentose phosphate pathway Platinum drug resistance -0.516521739 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Platinum drug resistance 0 0 0.503474903 kegg kegg NA NA no no no no no no Ruminococcus Platinum drug resistance 0 -0.442299524 0 Genus kegg 0.0679 NA no no dn no no no Selenocompound metabolism Platinum drug resistance 0.727826087 0.849802372 0.732818533 kegg kegg NA NA no no no no no no Slackia Platinum drug resistance 0 0 0.480668965 Genus kegg 0.94 NA no no no no no no Sphingolipid metabolism Platinum drug resistance -0.590434783 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Platinum drug resistance 0 0 0.482882883 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Platinum drug resistance 0 0.434782609 0.456628057 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Platinum drug resistance 0.622608696 0.662055336 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Platinum drug resistance 0.529565217 0.511857708 0.45019305 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Platinum drug resistance 0 0 0.426769627 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Platinum drug resistance 0 0 0.409009009 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Platinum drug resistance 0.564347826 0 0.55032175 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Porphyrin and chlorophyll metabolism 0 0 -0.436808237 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Porphyrin and chlorophyll metabolism 0.505217391 0 0.700643501 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Porphyrin and chlorophyll metabolism 0 0 -0.477220077 kegg kegg NA NA no no no no no no Butanoate metabolism Porphyrin and chlorophyll metabolism 0.420869565 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Porphyrin and chlorophyll metabolism 0 0 -0.473616474 kegg kegg NA NA no no no no no no Collinsella Porphyrin and chlorophyll metabolism 0.523934054 0 0 Genus kegg 0.128 NA no no no no no no Ether lipid metabolism Porphyrin and chlorophyll metabolism 0 0.568181818 0 kegg kegg NA NA no no no no no no Galactose metabolism Porphyrin and chlorophyll metabolism 0 -0.466403162 0 kegg kegg NA NA no no no no no no Glutathione metabolism Porphyrin and chlorophyll metabolism 0.662608696 0.651185771 0.820849421 kegg kegg NA NA no no no no no no Glycerolipid metabolism Porphyrin and chlorophyll metabolism 0 0 -0.467696268 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Porphyrin and chlorophyll metabolism 0 0 -0.437065637 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Porphyrin and chlorophyll metabolism 0.935652174 0.942687747 0.98018018 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Porphyrin and chlorophyll metabolism 0 0 -0.548519949 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Porphyrin and chlorophyll metabolism 0 -0.583003953 -0.594337194 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Porphyrin and chlorophyll metabolism 0 0.617588933 0 kegg kegg NA NA no no no no no no Lysine degradation Porphyrin and chlorophyll metabolism 0 0 -0.436036036 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Porphyrin and chlorophyll metabolism 0 -0.436758893 0 kegg kegg NA NA no no no no no no One carbon pool by folate Porphyrin and chlorophyll metabolism 0 0.416996047 0 kegg kegg NA NA no no no no no no Other glycan degradation Porphyrin and chlorophyll metabolism 0 0 -0.583011583 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Porphyrin and chlorophyll metabolism -0.537391304 -0.437747036 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Porphyrin and chlorophyll metabolism 0 0 -0.474646075 kegg kegg NA NA no no no no no no Pentose phosphate pathway Porphyrin and chlorophyll metabolism 0 -0.540513834 0 kegg kegg NA NA no no no no no no Purine metabolism Porphyrin and chlorophyll metabolism 0.724347826 0.922924901 0.624710425 kegg kegg NA NA no no no no no no Pyruvate metabolism Porphyrin and chlorophyll metabolism 0 0.441699605 0 kegg kegg NA NA no no no no no no Retinol metabolism Porphyrin and chlorophyll metabolism 0 0 -0.434234234 kegg kegg NA NA no no no no no no Sphingolipid metabolism Porphyrin and chlorophyll metabolism 0 0 -0.453281853 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Porphyrin and chlorophyll metabolism 0 -0.42687747 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Porphyrin and chlorophyll metabolism 0 0.476284585 0 kegg kegg NA NA no no no no no no Thiamine metabolism Porphyrin and chlorophyll metabolism 0 0.578063241 0.404633205 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Porphyrin and chlorophyll metabolism 0 0 -0.522265122 kegg kegg NA NA no no no no no no Prevotella Porphyromonas 0.483549128 0 0 Genus Genus 0.367 0.999 no no no no no no 2-Oxocarboxylic acid metabolism PPAR signaling pathway 0 -0.576086957 0 kegg kegg NA NA no no no no no no ABC transporters PPAR signaling pathway 0 0 -0.412355212 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" PPAR signaling pathway 0.492173913 0.770750988 0.402831403 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis PPAR signaling pathway 0 -0.472332016 -0.649163449 kegg kegg NA NA no no no no no no Antifolate resistance PPAR signaling pathway 0 -0.571146245 -0.423938224 kegg kegg NA NA no no no no no no Arginine and proline metabolism PPAR signaling pathway 0.600869565 0.716403162 0.616473616 kegg kegg NA NA no up no no no no Arginine biosynthesis PPAR signaling pathway 0.515652174 0.781620553 0.509137709 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism PPAR signaling pathway 0 -0.522727273 0 kegg kegg NA NA no no no no no no Basal transcription factors PPAR signaling pathway 0 -0.529644269 -0.578120978 kegg kegg NA NA no no no no no no Biosynthesis of amino acids PPAR signaling pathway 0 0.811264822 0.624967825 kegg kegg NA NA no no no no no no Biosynthesis of cofactors PPAR signaling pathway -0.433043478 -0.568181818 0 kegg kegg NA NA no no no no no no Butanoate metabolism PPAR signaling pathway 0 -0.621541502 -0.433462033 kegg kegg NA NA no no no no no no Carbon metabolism PPAR signaling pathway 0 0 0.431145431 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) PPAR signaling pathway 0 -0.587944664 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism PPAR signaling pathway 0 -0.566205534 -0.546718147 kegg kegg NA NA no no no no no no DNA replication PPAR signaling pathway 0 -0.741106719 -0.531016731 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 PPAR signaling pathway 0 -0.718379447 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes PPAR signaling pathway 0 -0.632411067 0 kegg kegg NA NA no no no no no no Endocrine resistance PPAR signaling pathway -0.492173913 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism PPAR signaling pathway -0.494782609 -0.577075099 -0.579150579 kegg kegg NA NA no no no no no no Fatty acid biosynthesis PPAR signaling pathway 0.569565217 0.765810277 0.486229086 kegg kegg NA NA no no no no no no Fatty acid degradation PPAR signaling pathway 0.430434783 0.618577075 0 kegg kegg NA NA no no no no no no Fatty acid metabolism PPAR signaling pathway 0.431304348 0.57312253 0 kegg kegg NA NA no no no no no no Folate biosynthesis PPAR signaling pathway 0 -0.424901186 0 kegg kegg NA NA no no no no no no Galactose metabolism PPAR signaling pathway 0 0.43083004 0 kegg kegg NA NA no no no no no no Glutathione metabolism PPAR signaling pathway 0 -0.601778656 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism PPAR signaling pathway 0 0 -0.538996139 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" PPAR signaling pathway -0.43826087 -0.431818182 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate PPAR signaling pathway 0.499130435 0.59486166 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin PPAR signaling pathway 0 -0.501976285 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate PPAR signaling pathway -0.469565217 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation PPAR signaling pathway 0 0.43083004 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series PPAR signaling pathway 0 -0.42687747 -0.584041184 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series PPAR signaling pathway 0.417391304 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PPAR signaling pathway 0 0 -0.40952381 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism PPAR signaling pathway 0.496521739 0.822134387 0.551608752 kegg kegg NA NA no no no no no no Inositol phosphate metabolism PPAR signaling pathway 0 0 -0.586615187 kegg kegg NA NA no no no no no no Linoleic acid metabolism PPAR signaling pathway 0 -0.565217391 0 kegg kegg NA NA no no no no no no Lysine degradation PPAR signaling pathway 0 0 -0.492664093 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis PPAR signaling pathway 0 0 -0.466924067 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 PPAR signaling pathway 0 -0.664031621 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway PPAR signaling pathway 0 -0.625494071 -0.492406692 kegg kegg NA NA no no no no no no N-Glycan biosynthesis PPAR signaling pathway -0.602608696 -0.761857708 -0.602574003 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism PPAR signaling pathway 0.597391304 0.732213439 0.708622909 kegg kegg NA NA no no no no no no Nitrogen metabolism PPAR signaling pathway 0.566956522 0.736166008 0.54028314 kegg kegg NA NA no no no no no no One carbon pool by folate PPAR signaling pathway 0 -0.780632411 -0.726383526 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis PPAR signaling pathway 0 0 -0.61003861 kegg kegg NA NA no no no no no no Oxidative phosphorylation PPAR signaling pathway 0 -0.597826087 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis PPAR signaling pathway 0.447826087 0.595849802 0.496782497 kegg kegg NA NA no no dn no no no Paraprevotella PPAR signaling pathway 0 -0.553626714 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions PPAR signaling pathway 0 -0.708498024 -0.416473616 kegg kegg NA NA no no no no no no Pentose phosphate pathway PPAR signaling pathway 0 0.68083004 0.611068211 kegg kegg NA NA no no no no no no Phenylalanine metabolism PPAR signaling pathway 0 -0.595849802 0 kegg kegg NA NA no no no no no no Platinum drug resistance PPAR signaling pathway 0 0 -0.581724582 kegg kegg NA NA no no no no no no Propanoate metabolism PPAR signaling pathway 0 -0.493083004 -0.446074646 kegg kegg NA NA no no no no no no Protein export PPAR signaling pathway 0 -0.589920949 0 kegg kegg NA NA no no no no no no Purine metabolism PPAR signaling pathway 0 -0.464426877 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism PPAR signaling pathway 0 -0.757905138 0 kegg kegg NA NA no no no no no no Pyruvate metabolism PPAR signaling pathway 0 -0.608695652 -0.488288288 kegg kegg NA NA no no no no no no Retinol metabolism PPAR signaling pathway 0 -0.60770751 -0.473359073 kegg kegg NA NA no no no no no no Ribosome PPAR signaling pathway 0 -0.488142292 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes PPAR signaling pathway 0 -0.630434783 -0.671299871 kegg kegg NA NA no no no no no no RNA degradation PPAR signaling pathway 0 -0.7243083 -0.473359073 kegg kegg NA NA no no no no no no RNA polymerase PPAR signaling pathway 0 -0.735177866 -0.618018018 kegg kegg NA NA no no no no no no Selenocompound metabolism PPAR signaling pathway 0 0 -0.626512227 kegg kegg NA NA no no no no no no Slackia PPAR signaling pathway 0 0 -0.417321675 Genus kegg 0.94 NA no no no no no no Spliceosome PPAR signaling pathway 0 0 -0.461776062 kegg kegg NA NA no no no no no no Starch and sucrose metabolism PPAR signaling pathway 0 0.650197628 0 kegg kegg NA NA no no no no no no Steroid biosynthesis PPAR signaling pathway -0.509565217 -0.528656126 -0.619305019 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis PPAR signaling pathway 0 -0.559288538 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies PPAR signaling pathway 0 -0.545454545 -0.557014157 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis PPAR signaling pathway 0 0 -0.433976834 kegg kegg NA NA no no no no no no Tryptophan metabolism PPAR signaling pathway 0 -0.436758893 0 kegg kegg NA NA no up no no no no Tyrosine metabolism PPAR signaling pathway 0 -0.688735178 -0.402574003 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis PPAR signaling pathway 0 -0.609683794 -0.581724582 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" PPAR signaling pathway 0 -0.644268775 -0.546718147 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis PPAR signaling pathway 0 -0.563241107 -0.433204633 kegg kegg NA NA no no no no no no Butyricimonas Prevotella 0.432886335 0 0 butyrate-producing acetate-producing Genus Genus 0.17 0.287 no no no no no no Ascorbate and aldarate metabolism Primary bile acid biosynthesis 0.656521739 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Primary bile acid biosynthesis 0.862608696 0.751976285 0 kegg kegg NA NA no no no no no no Fatty acid degradation Primary bile acid biosynthesis 0.431304348 0 0.524581725 kegg kegg NA NA no no no no no no Fatty acid elongation Primary bile acid biosynthesis 0.785217391 0.805335968 0.765508366 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Primary bile acid biosynthesis 0.439130435 -0.481225296 0 kegg kegg NA NA no no no no no no Galactose metabolism Primary bile acid biosynthesis 0.52 0 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Primary bile acid biosynthesis 0.639130435 0.734189723 0.651737452 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Primary bile acid biosynthesis 0.780869565 0.549407115 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Primary bile acid biosynthesis 0 0.79743083 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Primary bile acid biosynthesis 0.82173913 0.623517787 0.404375804 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Primary immunodeficiency 0 0.5 0.46048906 kegg kegg NA NA no no no no no no ABC transporters Primary immunodeficiency 0.435652174 0.422924901 0 kegg kegg NA NA no up up no no no Acute myeloid leukemia Primary immunodeficiency 0 -0.649209486 -0.466151866 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Primary immunodeficiency -0.72173913 0 -0.418532819 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Primary immunodeficiency 0 -0.505928854 0 kegg kegg NA NA no no no no no no Alistipes Primary immunodeficiency -0.414851117 0 0 Genus kegg 0.0114 NA no up no no no no Allograft rejection Primary immunodeficiency 0 -0.526679842 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Primary immunodeficiency 0.420869565 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Primary immunodeficiency 0.663478261 0.574110672 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Primary immunodeficiency 0.656521739 0.776679842 0.577348777 kegg kegg NA NA no no no no no no Amoebiasis Primary immunodeficiency 0 -0.545454545 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Primary immunodeficiency -0.451304348 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Primary immunodeficiency 0 0.563241107 0 kegg kegg NA NA no no no no no no Apoptosis Primary immunodeficiency 0 -0.621541502 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Primary immunodeficiency 0 0.53458498 0.452767053 kegg kegg NA NA no no no no no no Arginine and proline metabolism Primary immunodeficiency 0 0 -0.431660232 kegg kegg NA NA no up no no no no Autoimmune thyroid disease Primary immunodeficiency 0 -0.526679842 0 kegg kegg NA NA no no no no no no Axon guidance Primary immunodeficiency 0 -0.464426877 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Primary immunodeficiency -0.527826087 -0.562252964 -0.841184041 kegg kegg NA NA no no no no no no Basal transcription factors Primary immunodeficiency 0 0.651185771 0.468725869 kegg kegg NA NA no no no no no no Base excision repair Primary immunodeficiency 0 0.785573123 0.679021879 kegg kegg NA NA no no no no no no beta-Alanine metabolism Primary immunodeficiency 0.504347826 0.423913043 0.643243243 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Primary immunodeficiency 0 0.602766798 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Primary immunodeficiency 0.647826087 0.543478261 0.698069498 kegg kegg NA NA no no no no no no Bladder cancer Primary immunodeficiency 0 -0.475296443 0 kegg kegg NA NA no no no no no no Butanoate metabolism Primary immunodeficiency 0.523478261 0.622529644 0.675160875 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Primary immunodeficiency 0 -0.52173913 -0.674646075 kegg kegg NA NA no no no no no no Calcium signaling pathway Primary immunodeficiency -0.495652174 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Primary immunodeficiency -0.459130435 -0.726284585 -0.616473616 yes kegg kegg NA NA no up up no no no Carbon metabolism Primary immunodeficiency 0.446086957 0 0 kegg kegg NA NA no no no no no no Cell cycle Primary immunodeficiency 0.536521739 0.710474308 0 kegg kegg NA NA no no no no no no Cellular senescence Primary immunodeficiency 0 -0.541501976 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Primary immunodeficiency 0.593043478 0 0.499356499 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Primary immunodeficiency 0 -0.462450593 0 kegg kegg NA NA no no no no no no Chagas disease Primary immunodeficiency 0 -0.527667984 -0.444015444 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Primary immunodeficiency 0.61826087 0 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Primary immunodeficiency 0 -0.575098814 -0.424195624 kegg kegg NA NA no no no no no no Cholesterol metabolism Primary immunodeficiency -0.512173913 -0.484189723 -0.45045045 yes kegg kegg NA NA no no up no no no Chronic myeloid leukemia Primary immunodeficiency -0.493913043 -0.529644269 -0.651222651 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Primary immunodeficiency 0.610434783 0.615612648 0.562162162 kegg kegg NA NA no no no no no no Cocaine addiction Primary immunodeficiency -0.490434783 0 -0.456370656 kegg kegg NA NA no no no no no no Colorectal cancer Primary immunodeficiency -0.409565217 0 0 kegg kegg NA NA no no no no no no Coprococcus Primary immunodeficiency 0.435652174 0 0 butyrate-producing Genus kegg 0.612 NA no no no no no no Cysteine and methionine metabolism Primary immunodeficiency 0.813043478 0.579051383 0.743886744 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Primary immunodeficiency 0 -0.531620553 -0.53024453 kegg kegg NA NA no no no no no no DNA replication Primary immunodeficiency 0.59826087 0.751976285 0.568854569 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Primary immunodeficiency 0.467826087 0.502964427 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Primary immunodeficiency 0.530434783 0 0 kegg kegg NA NA no no no no no no Endocytosis Primary immunodeficiency 0 -0.432806324 0 kegg kegg NA NA no no no no no no Endometrial cancer Primary immunodeficiency 0 -0.517786561 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Primary immunodeficiency 0 -0.567193676 -0.637580438 kegg kegg NA NA no no no no no no Estrogen signaling pathway Primary immunodeficiency 0.669565217 0.598814229 0.535907336 kegg kegg NA NA no no no no no no Ether lipid metabolism Primary immunodeficiency -0.432173913 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Primary immunodeficiency 0.650434783 0.846837945 0.643500644 kegg kegg NA NA no no no no no no Fatty acid degradation Primary immunodeficiency 0.573043478 0 0.41003861 kegg kegg NA NA no no no no no no Fatty acid elongation Primary immunodeficiency 0.494782609 0 0.688545689 kegg kegg NA NA no no no no no no Fatty acid metabolism Primary immunodeficiency 0.546956522 0 0.423680824 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Primary immunodeficiency -0.457391304 -0.489130435 -0.448391248 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Primary immunodeficiency 0.422608696 0 0 kegg kegg NA NA no no no no no no Ferroptosis Primary immunodeficiency -0.424347826 -0.590909091 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Primary immunodeficiency 0.51826087 0 0.661261261 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Primary immunodeficiency 0 0.440711462 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Primary immunodeficiency 0.650434783 0 0.430888031 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Primary immunodeficiency -0.623478261 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Primary immunodeficiency 0 0.576086957 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Primary immunodeficiency -0.663478261 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Primary immunodeficiency 0.473043478 0.564229249 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Primary immunodeficiency 0 -0.526679842 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Primary immunodeficiency 0 0 -0.410810811 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Primary immunodeficiency 0 0.721343874 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Primary immunodeficiency 0 0 0.513770914 kegg kegg NA NA no no no no no no Hepatitis B Primary immunodeficiency 0 0 -0.517374517 kegg kegg NA NA no no no no no no Histidine metabolism Primary immunodeficiency 0 0 0.418018018 kegg kegg NA NA no no no no no no Homologous recombination Primary immunodeficiency 0.74173913 0.748023715 0.65997426 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Primary immunodeficiency 0 -0.434782609 0 kegg kegg NA NA no no dn no no no Human papillomavirus infection Primary immunodeficiency 0 -0.530632411 -0.405662806 kegg kegg NA NA no no no no no no Huntington disease Primary immunodeficiency -0.473913043 0 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Primary immunodeficiency 0 -0.544466403 -0.433976834 kegg kegg NA NA no no no no no no Influenza A Primary immunodeficiency 0 -0.54743083 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Primary immunodeficiency 0 0.492094862 0 kegg kegg NA NA no no no no no no Insulin resistance Primary immunodeficiency 0 0 -0.441698842 kegg kegg NA NA no no no no no no Insulin secretion Primary immunodeficiency -0.428695652 0 0 yes kegg kegg NA NA no up up no no no Intestinal immune network for IgA production Primary immunodeficiency -0.440869565 0 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Primary immunodeficiency 0.432173913 0 0 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Primary immunodeficiency -0.673043478 -0.480237154 0 kegg kegg NA NA no no dn no no no Legionellosis Primary immunodeficiency 0.579130435 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Primary immunodeficiency 0.466956522 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Primary immunodeficiency 0 -0.456521739 0 kegg kegg NA NA no no no no no no Long-term depression Primary immunodeficiency -0.534782609 -0.600790514 0 kegg kegg NA NA no no no no no no Long-term potentiation Primary immunodeficiency 0 0.502964427 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Primary immunodeficiency -0.476521739 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Primary immunodeficiency 0.790434783 0.446640316 0.785585586 kegg kegg NA NA no no no no no no Lysine degradation Primary immunodeficiency 0 0.427865613 0 kegg kegg NA NA no no no no no no Lysosome Primary immunodeficiency 0 -0.570158103 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Primary immunodeficiency -0.585217391 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Primary immunodeficiency 0.529565217 0.566205534 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Primary immunodeficiency -0.552173913 0 0 kegg kegg NA NA no up no no no no Melanoma Primary immunodeficiency 0 -0.425889328 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Primary immunodeficiency 0.493043478 0.461462451 0 kegg kegg NA NA no no no no no no Mineral absorption Primary immunodeficiency -0.485217391 0 0 kegg kegg NA NA no no no no no no Mismatch repair Primary immunodeficiency 0.666956522 0.806324111 0.675160875 kegg kegg NA NA no no no no no no Mitophagy - animal Primary immunodeficiency -0.545217391 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Primary immunodeficiency 0.770434783 0.4743083 0.481853282 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Primary immunodeficiency 0 0.458498024 0.562676963 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Primary immunodeficiency 0 -0.485177866 0 kegg kegg NA NA no no no no no no Necroptosis Primary immunodeficiency 0 -0.443675889 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Primary immunodeficiency 0.42 0 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Primary immunodeficiency -0.46173913 -0.601778656 -0.701415701 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Primary immunodeficiency 0 0 -0.456370656 kegg kegg NA NA no no no no no no Nicotine addiction Primary immunodeficiency -0.406956522 0.440711462 -0.607979408 kegg kegg NA NA no up up no no no Non-alcoholic fatty liver disease Primary immunodeficiency -0.442608696 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Primary immunodeficiency 0.64 0.537549407 0.739253539 kegg kegg NA NA no no no no no no Notch signaling pathway Primary immunodeficiency -0.495652174 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Primary immunodeficiency 0.632173913 0.838932806 0.729214929 kegg kegg NA NA no no no no no no One carbon pool by folate Primary immunodeficiency 0.660869565 0.732213439 0.531016731 kegg kegg NA NA no no no no no no Oocyte meiosis Primary immunodeficiency 0 0.441699605 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Primary immunodeficiency 0 0 -0.518918919 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Primary immunodeficiency 0 0.484189723 0 kegg kegg NA NA no no no no no no p53 signaling pathway Primary immunodeficiency 0 0.432806324 0 kegg kegg NA NA no no no no no no Pancreatic secretion Primary immunodeficiency -0.494782609 0 0 kegg kegg NA NA no no no no no no Parkinson disease Primary immunodeficiency -0.554782609 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Primary immunodeficiency 0 -0.444664032 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Primary immunodeficiency -0.577391304 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Primary immunodeficiency 0.568695652 0.54743083 0.44993565 kegg kegg NA NA no no no no no no Pentose phosphate pathway Primary immunodeficiency 0 -0.43972332 0 kegg kegg NA NA no no no no no no Peroxisome Primary immunodeficiency 0.46173913 0 0 kegg kegg NA NA no no no no no no Phagosome Primary immunodeficiency 0 -0.479249012 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Primary immunodeficiency 0 0.566205534 0.459202059 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Primary immunodeficiency 0 0.663043478 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Primary immunodeficiency -0.429565217 0 -0.435521236 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Primary immunodeficiency 0.53826087 0 0.453024453 yes kegg kegg NA NA no up up no no no Platinum drug resistance Primary immunodeficiency 0 0.563241107 0.524581725 kegg kegg NA NA no no no no no no PPAR signaling pathway Primary immunodeficiency 0 0 -0.481081081 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Primary immunodeficiency 0.683478261 0.438735178 0.498841699 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Primary immunodeficiency 0 0.641304348 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Primary immunodeficiency 0 -0.443675889 0 kegg kegg NA NA no no no no no no Propanoate metabolism Primary immunodeficiency 0.863478261 0.542490119 0.692149292 kegg kegg NA NA no no no no no no Prostate cancer Primary immunodeficiency 0 -0.535573123 -0.607979408 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Primary immunodeficiency 0.494782609 0.502964427 0.465122265 kegg kegg NA NA no no no no no no Pyrimidine metabolism Primary immunodeficiency 0.59826087 0.548418972 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Primary immunodeficiency 0.81826087 0.539525692 0.683397683 kegg kegg NA NA no no no no no no Rap1 signaling pathway Primary immunodeficiency 0 -0.443675889 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Primary immunodeficiency -0.604347826 -0.670948617 -0.774774775 kegg kegg NA NA no no no no no no Renin-angiotensin system Primary immunodeficiency 0 -0.460474308 0 kegg kegg NA NA no no no no no no Retinol metabolism Primary immunodeficiency 0.80173913 0.802371542 0.625225225 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Primary immunodeficiency 0 0.77173913 0.509395109 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Primary immunodeficiency 0 0 -0.538481338 kegg kegg NA NA no no no no no no RNA polymerase Primary immunodeficiency 0 0.650197628 0.482368082 kegg kegg NA NA no no no no no no RNA transport Primary immunodeficiency 0.545217391 0 0.423938224 kegg kegg NA NA no no no no no no Salmonella infection Primary immunodeficiency 0.493043478 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Primary immunodeficiency 0 0.741106719 0.498841699 kegg kegg NA NA no no no no no no Shigellosis Primary immunodeficiency -0.513913043 0 0 kegg kegg NA NA no no no no no no Slackia Primary immunodeficiency 0 0 0.437866742 Genus kegg 0.94 NA no no no no no no Small cell lung cancer Primary immunodeficiency 0 0 -0.497039897 kegg kegg NA NA no no up no no no Sphingolipid metabolism Primary immunodeficiency -0.464347826 -0.455533597 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Primary immunodeficiency 0 -0.586956522 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Primary immunodeficiency 0 0.528656126 0 kegg kegg NA NA no no no no no no Spliceosome Primary immunodeficiency 0 0.566205534 0.414929215 kegg kegg NA NA no no no no no no Steroid biosynthesis Primary immunodeficiency 0 0.635375494 0.64015444 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Primary immunodeficiency 0.556521739 0.563241107 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Primary immunodeficiency 0.774782609 0.867588933 0.684942085 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Primary immunodeficiency 0 -0.435770751 0 kegg kegg NA NA no no no no no no Taste transduction Primary immunodeficiency 0.691304348 0.849802372 0 kegg kegg NA NA no no up no no no Terpenoid backbone biosynthesis Primary immunodeficiency 0.425217391 0.647233202 0.435263835 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Primary immunodeficiency -0.62 0 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Primary immunodeficiency -0.488695652 0 0 kegg kegg NA NA no no no no no no Thermogenesis Primary immunodeficiency -0.431304348 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Primary immunodeficiency 0.5 0.450592885 0 kegg kegg NA NA no no no no no no TNF signaling pathway Primary immunodeficiency 0 -0.472332016 -0.716344916 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Primary immunodeficiency 0 -0.532608696 -0.67953668 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Primary immunodeficiency 0.571304348 0.542490119 0.561647362 kegg kegg NA NA no up no no no no Type I diabetes mellitus Primary immunodeficiency 0 -0.516798419 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Primary immunodeficiency 0.600869565 0.634387352 0.741312741 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Primary immunodeficiency 0.626956522 0.825098814 0.559330759 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Primary immunodeficiency -0.529565217 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Primary immunodeficiency 0.66173913 0.704545455 0.757014157 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Primary immunodeficiency 0 0.456521739 0.583268983 kegg kegg NA NA no no no no no no VEGF signaling pathway Primary immunodeficiency 0 -0.418972332 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Primary immunodeficiency 0 -0.564229249 -0.528957529 kegg kegg NA NA no no no no no no Wnt signaling pathway Primary immunodeficiency -0.428695652 0 0 kegg kegg NA NA no no no no no no Yersinia infection Primary immunodeficiency 0 -0.432806324 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Prion disease -0.460869565 0.424901186 0 kegg kegg NA NA no no no no no no ABC transporters Prion disease -0.42 -0.476284585 0 kegg kegg NA NA no up up no no no Adherens junction Prion disease 0 0.695652174 0.644272844 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Prion disease 0.71826087 0.792490119 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Prion disease 0 -0.848814229 -0.431145431 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Prion disease -0.57826087 -0.809288538 -0.542857143 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Prion disease 0.530434783 0.700592885 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Prion disease -0.539130435 -0.770750988 0 kegg kegg NA NA no no no no no no Alzheimer disease Prion disease 0.95826087 0.976284585 0.932818533 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Prion disease -0.51826087 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Prion disease -0.551304348 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Prion disease 0.946956522 0.953557312 0.915315315 kegg kegg NA NA no no no no no no Apelin signaling pathway Prion disease 0 0.833003953 0 kegg kegg NA NA no no no no no no Apoptosis Prion disease 0 -0.621541502 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Prion disease 0 -0.481225296 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Prion disease 0 -0.788537549 -0.594337194 kegg kegg NA NA no up no no no no Arginine biosynthesis Prion disease -0.580869565 -0.749011858 -0.494723295 kegg kegg NA NA no no no no no no Autophagy - animal Prion disease 0 -0.769762846 -0.526898327 kegg kegg NA NA no no no no no no Axon guidance Prion disease 0.489565217 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Prion disease 0 -0.646245059 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Prion disease -0.649565217 0 0 kegg kegg NA NA no no no no no no Bile secretion Prion disease 0.440869565 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Prion disease -0.710434783 -0.613636364 0 kegg kegg NA NA no no no no no no Butanoate metabolism Prion disease -0.512173913 0.492094862 0 kegg kegg NA NA no no no no no no Butyricimonas Prion disease 0.425194231 0 -0.420211079 butyrate-producing Genus kegg 0.17 NA no no no no no no C-type lectin receptor signaling pathway Prion disease 0 -0.646245059 -0.432432432 kegg kegg NA NA no no no no no no Calcium signaling pathway Prion disease 0.639130435 0.654150198 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Prion disease 0.731304348 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Prion disease 0 -0.533596838 0 kegg kegg NA NA no no no no no no Carbon metabolism Prion disease -0.636521739 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Prion disease 0.956521739 0.948616601 0.935907336 kegg kegg NA NA no no up no no no Cell adhesion molecules Prion disease -0.504347826 0 0 kegg kegg NA NA no no no no no no Cell cycle Prion disease 0 0.41798419 0 kegg kegg NA NA no no no no no no Cellular senescence Prion disease 0 -0.434782609 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Prion disease 0 -0.633399209 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Prion disease 0 -0.473320158 0 kegg kegg NA NA no no no no no no Circadian entrainment Prion disease 0.43826087 0.562252964 0 kegg kegg NA NA no up up no no no Circadian rhythm Prion disease 0.564347826 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Prion disease 0 0.539525692 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Prion disease -0.505217391 -0.637351779 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Prion disease 0 0.598814229 0 kegg kegg NA NA no no no no no no DNA replication Prion disease 0 0.515810277 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Prion disease 0.660869565 0.682806324 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Prion disease 0 0.58201581 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Prion disease -0.463478261 0.65513834 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Prion disease 0 0.748023715 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Prion disease 0.486956522 0.733201581 0 kegg kegg NA NA no no no no no no Endocytosis Prion disease -0.416521739 -0.419960474 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Prion disease 0 -0.489130435 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Prion disease 0 0.424901186 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Prion disease 0.587826087 0.449604743 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Prion disease -0.468695652 -0.634387352 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Prion disease -0.415652174 -0.839920949 -0.580694981 kegg kegg NA NA no no no no no no Fatty acid degradation Prion disease -0.579130435 -0.81916996 0 kegg kegg NA NA no no no no no no Fatty acid elongation Prion disease -0.416521739 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Prion disease -0.688695652 -0.782608696 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Prion disease 0 -0.751976285 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Prion disease 0 -0.585968379 0 kegg kegg NA NA no no no no no no Focal adhesion Prion disease 0 0.596837945 0.593822394 kegg kegg NA NA no up up no no no Folate biosynthesis Prion disease 0 0.471343874 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Prion disease 0 -0.788537549 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Prion disease -0.710434783 -0.659090909 -0.524581725 kegg kegg NA NA no no no no no no GABAergic synapse Prion disease 0 -0.647233202 0 kegg kegg NA NA no up up no no no Galactose metabolism Prion disease -0.703478261 -0.785573123 0 kegg kegg NA NA no no no no no no Gastric acid secretion Prion disease 0 0.729249012 0.57014157 kegg kegg NA NA no no no no no no Glucagon signaling pathway Prion disease 0.424347826 0.719367589 0 kegg kegg NA NA no no no no no no Glutathione metabolism Prion disease 0 0.684782609 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Prion disease 0 -0.694664032 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Prion disease 0 -0.464426877 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Prion disease -0.492173913 0.566205534 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Prion disease -0.449565217 -0.828063241 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Prion disease 0.415652174 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Prion disease -0.712173913 -0.748023715 -0.544916345 kegg kegg NA NA no no no no no no GnRH secretion Prion disease 0 -0.495059289 0 kegg kegg NA NA no up up no no no Hedgehog signaling pathway Prion disease 0.413043478 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Prion disease 0 0.729249012 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Prion disease 0 0.696640316 0.685199485 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Prion disease 0 -0.752964427 0 kegg kegg NA NA no no no no no no Huntington disease Prion disease 0.946956522 0.964426877 0.932046332 kegg kegg NA NA no no no no no no IL-17 signaling pathway Prion disease 0 -0.563241107 -0.457400257 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Prion disease 0.524347826 0.779644269 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Prion disease 0 -0.498023715 0 kegg kegg NA NA no no no no no no Insulin resistance Prion disease 0 -0.632411067 0 kegg kegg NA NA no no no no no no Insulin secretion Prion disease 0 0.422924901 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Prion disease 0 0.780632411 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Prion disease 0 -0.81916996 0 kegg kegg NA NA no no no no no no Long-term depression Prion disease 0.513913043 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Prion disease 0.417391304 0.508893281 0 kegg kegg NA NA no no up no no no MAPK signaling pathway Prion disease 0 -0.628458498 0 kegg kegg NA NA no no no no no no Melanogenesis Prion disease 0.522608696 0.806324111 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Prion disease 0 0.54743083 0 kegg kegg NA NA no no no no no no Mineral absorption Prion disease 0 0.486166008 0 kegg kegg NA NA no no no no no no Mitophagy - animal Prion disease 0.434782609 0.748023715 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Prion disease 0.607826087 0.639328063 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Prion disease 0 0.744071146 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Prion disease 0 0.623517787 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Prion disease 0 -0.433794466 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Prion disease 0.483478261 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Prion disease -0.426956522 -0.503952569 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Prion disease 0 -0.787549407 -0.534877735 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Prion disease -0.43826087 -0.793478261 -0.506821107 kegg kegg NA NA no no no no no no Nitrogen metabolism Prion disease -0.50173913 -0.66798419 -0.499099099 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Prion disease 0 -0.768774704 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Prion disease 0.933913043 0.912055336 0.825482625 kegg kegg NA NA no no no no no no Non-homologous end-joining Prion disease -0.503478261 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Prion disease 0 -0.446640316 0 kegg kegg NA NA no no no no no no Olfactory transduction Prion disease 0 -0.556324111 0 kegg kegg NA NA no no no no no no Oocyte meiosis Prion disease 0.505217391 0.605731225 0.432432432 kegg kegg NA NA no no no no no no Oscillospira Prion disease 0 -0.475296443 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Prion disease 0 -0.720355731 -0.411325611 kegg kegg NA NA no no no no no no Other glycan degradation Prion disease -0.419130435 -0.542490119 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Prion disease 0.976521739 0.975296443 0.958301158 kegg kegg NA NA no no no no no no Pancreatic secretion Prion disease 0.64 0.66798419 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Prion disease 0 -0.799407115 -0.473873874 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Prion disease 0.628695652 0.738142292 0 kegg kegg NA NA no no no no no no Parkinson disease Prion disease 0.756521739 0.922924901 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Prion disease 0 0.636363636 0.492406692 kegg kegg NA NA no no no no no no Pentose phosphate pathway Prion disease -0.494782609 -0.53458498 -0.438095238 kegg kegg NA NA no no no no no no Peroxisome Prion disease -0.562608696 -0.742094862 0 kegg kegg NA NA no no no no no no Phagosome Prion disease -0.552173913 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Prion disease 0 0.423913043 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Prion disease 0.467826087 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Prion disease 0 -0.658102767 0 kegg kegg NA NA no up up no no no Phototransduction Prion disease 0.410434783 0.644268775 0.516602317 kegg kegg NA NA no no no no no no Platelet activation Prion disease 0 0.551383399 0.432432432 kegg kegg NA NA no no no no no no PPAR signaling pathway Prion disease 0 -0.604743083 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Prion disease 0 -0.713438735 -0.47027027 kegg kegg NA NA no no no no no no Propanoate metabolism Prion disease 0 0.566205534 0 kegg kegg NA NA no no no no no no Proteasome Prion disease 0 0.593873518 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Prion disease -0.669565217 -0.804347826 -0.503474903 yes kegg kegg NA NA no up up no no no Protein export Prion disease 0.525217391 0.846837945 0.462290862 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Prion disease 0 0.672924901 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Prion disease 0 0.563241107 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Prion disease -0.663478261 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Prion disease 0 0.665019763 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Prion disease 0 0 0.417245817 kegg kegg NA NA no no no no no no Ras signaling pathway Prion disease 0 0.610671937 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Prion disease 0 0.496047431 0.542342342 kegg kegg NA NA no no no no no no Relaxin signaling pathway Prion disease 0.455652174 0 0 kegg kegg NA NA no no no no no no Renin secretion Prion disease 0 0.800395257 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Prion disease 0 -0.54743083 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Prion disease 0.88173913 0.928853755 0.827799228 kegg kegg NA NA no no up no no no Ribosome Prion disease 0.628695652 0.891304348 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Prion disease 0 -0.734189723 -0.488803089 kegg kegg NA NA no no no no no no RNA degradation Prion disease 0.564347826 0.703557312 0 kegg kegg NA NA no no no no no no RNA polymerase Prion disease 0 0.571146245 0 kegg kegg NA NA no no no no no no RNA transport Prion disease 0 0.660079051 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Prion disease 0.506086957 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Prion disease 0 -0.694664032 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Prion disease -0.413043478 -0.849802372 0 kegg kegg NA NA no no no no no no Sulfur metabolism Prion disease -0.467826087 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Prion disease 0 -0.537549407 0 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Prion disease 0 -0.476284585 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Prion disease 0 -0.523715415 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Prion disease 0.665217391 0.772727273 0.455083655 kegg kegg NA NA no no no no no no Thermogenesis Prion disease 0.936521739 0.982213439 0.937709138 kegg kegg NA NA no no no no no no Thiamine metabolism Prion disease 0 0.540513834 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Prion disease 0 0.622529644 0.597683398 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Prion disease 0 0.503952569 0 kegg kegg NA NA no no no no no no Tight junction Prion disease 0 0.590909091 0 kegg kegg NA NA no no no no no no TNF signaling pathway Prion disease 0 -0.606719368 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Prion disease 0 -0.686758893 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Prion disease -0.462608696 0 0 kegg kegg NA NA no up no no no no Type I diabetes mellitus Prion disease -0.459130435 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Prion disease 0 -0.666996047 -0.46023166 kegg kegg NA NA no no no no no no Tyrosine metabolism Prion disease 0 0.418972332 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Prion disease 0.433043478 0.766798419 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Prion disease 0 0.420948617 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Prion disease 0.66173913 0.847826087 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Prion disease 0.533913043 0.701581028 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Prion disease 0 -0.438735178 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Prion disease 0.53826087 -0.446640316 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Prion disease 0.637391304 0.681818182 0 kegg kegg NA NA no no no no no no ABC transporters Progesterone-mediated oocyte maturation 0 0.805335968 0 kegg kegg NA NA no up up no no no Adherens junction Progesterone-mediated oocyte maturation -0.62173913 -0.565217391 0 kegg kegg NA NA no no no no no no Alistipes Progesterone-mediated oocyte maturation -0.410484263 0 0 Genus kegg 0.0114 NA no up no no no no Amino sugar and nucleotide sugar metabolism Progesterone-mediated oocyte maturation 0 0.438735178 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Progesterone-mediated oocyte maturation 0 0.568181818 0.481595882 kegg kegg NA NA no no no no no no AMPK signaling pathway Progesterone-mediated oocyte maturation 0 0 -0.511454311 kegg kegg NA NA no no no no no no Antifolate resistance Progesterone-mediated oocyte maturation 0 0.545454545 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Progesterone-mediated oocyte maturation 0 -0.593873518 -0.43037323 kegg kegg NA NA no no no no no no Apoptosis Progesterone-mediated oocyte maturation 0 0 -0.401544402 kegg kegg NA NA no no no no no no Apoptosis - multiple species Progesterone-mediated oocyte maturation 0.467826087 0.831027668 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Progesterone-mediated oocyte maturation -0.553913043 -0.443675889 -0.776833977 kegg kegg NA NA no no no no no no Arginine biosynthesis Progesterone-mediated oocyte maturation 0 0 -0.401801802 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Progesterone-mediated oocyte maturation 0 0 0.558043758 kegg kegg NA NA no no no no no no Autophagy - animal Progesterone-mediated oocyte maturation 0.694782609 0 0.497039897 kegg kegg NA NA no no no no no no Autophagy - other Progesterone-mediated oocyte maturation 0.719130435 0.694664032 0.73976834 kegg kegg NA NA no no no no no no Basal transcription factors Progesterone-mediated oocyte maturation 0.571304348 0.585968379 0.774517375 kegg kegg NA NA no no no no no no Base excision repair Progesterone-mediated oocyte maturation 0.540869565 0.70256917 0.582754183 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Progesterone-mediated oocyte maturation 0 0 -0.592020592 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Progesterone-mediated oocyte maturation -0.479130435 0 -0.659202059 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Progesterone-mediated oocyte maturation 0.419130435 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Progesterone-mediated oocyte maturation 0 0 -0.431660232 kegg kegg NA NA no no no no no no Cell cycle Progesterone-mediated oocyte maturation 0.605217391 0.595849802 0.715830116 kegg kegg NA NA no no no no no no Chemokine signaling pathway Progesterone-mediated oocyte maturation 0 0 -0.470785071 kegg kegg NA NA no no no no no no Cholinergic synapse Progesterone-mediated oocyte maturation 0.643478261 0 0.482110682 kegg kegg NA NA no no no no no no Circadian entrainment Progesterone-mediated oocyte maturation 0 0 -0.425740026 kegg kegg NA NA no up up no no no Circadian rhythm Progesterone-mediated oocyte maturation 0.508695652 0.671936759 0.714028314 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Progesterone-mediated oocyte maturation 0 0 0.491634492 kegg kegg NA NA no no no no no no Complement and coagulation cascades Progesterone-mediated oocyte maturation 0 0 -0.539253539 kegg kegg NA NA no no no no no no DNA replication Progesterone-mediated oocyte maturation 0.420869565 0 0.556499356 kegg kegg NA NA no no no no no no ErbB signaling pathway Progesterone-mediated oocyte maturation 0.488695652 0.57312253 0.723552124 kegg kegg NA NA no no no no no no Ether lipid metabolism Progesterone-mediated oocyte maturation 0 0 0.497297297 kegg kegg NA NA no no no no no no Fanconi anemia pathway Progesterone-mediated oocyte maturation 0.476521739 0.782608696 0.655855856 kegg kegg NA NA no no no no no no Ferroptosis Progesterone-mediated oocyte maturation -0.465217391 0 -0.676447876 kegg kegg NA NA no no no no no no Focal adhesion Progesterone-mediated oocyte maturation -0.43826087 -0.551383399 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Progesterone-mediated oocyte maturation 0.700869565 0.661067194 0.536936937 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Progesterone-mediated oocyte maturation 0 0.448616601 0 kegg kegg NA NA no no no no no no Gap junction Progesterone-mediated oocyte maturation 0 0 -0.517374517 kegg kegg NA NA no no no no no no Glutamatergic synapse Progesterone-mediated oocyte maturation 0 0 -0.476190476 kegg kegg NA NA no up up no no no Glutathione metabolism Progesterone-mediated oocyte maturation -0.585217391 0 -0.772458172 kegg kegg NA NA no no no no no no Glycerolipid metabolism Progesterone-mediated oocyte maturation 0 0.759881423 0.683140283 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Progesterone-mediated oocyte maturation 0 0.746047431 0.786357786 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Progesterone-mediated oocyte maturation -0.512173913 0 -0.687773488 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Progesterone-mediated oocyte maturation 0 0 0.531274131 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Progesterone-mediated oocyte maturation 0 0 0.433204633 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Progesterone-mediated oocyte maturation 0 0.484189723 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Progesterone-mediated oocyte maturation 0.529565217 0.544466403 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Progesterone-mediated oocyte maturation 0 0.812252964 0.762934363 kegg kegg NA NA no no no no no no Hippo signaling pathway Progesterone-mediated oocyte maturation -0.520869565 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Progesterone-mediated oocyte maturation 0 0 0.478249678 kegg kegg NA NA no no no no no no Homologous recombination Progesterone-mediated oocyte maturation 0.56173913 0.789525692 0.579407979 kegg kegg NA NA no no no no no no IL-17 signaling pathway Progesterone-mediated oocyte maturation 0 -0.416007905 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Progesterone-mediated oocyte maturation 0 0.877470356 0.762419562 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Progesterone-mediated oocyte maturation 0 -0.423913043 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Progesterone-mediated oocyte maturation 0 0.576086957 0 kegg kegg NA NA no no no no no no Lachnospira Progesterone-mediated oocyte maturation 0 -0.52087968 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Leukocyte transendothelial migration Progesterone-mediated oocyte maturation 0 -0.695652174 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Progesterone-mediated oocyte maturation 0 0 0.435778636 kegg kegg NA NA no no no no no no Long-term potentiation Progesterone-mediated oocyte maturation 0.569565217 0 0.606177606 kegg kegg NA NA no no up no no no Longevity regulating pathway Progesterone-mediated oocyte maturation 0 0 -0.463835264 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Progesterone-mediated oocyte maturation 0.483478261 0 0 kegg kegg NA NA no no no no no no Lysine degradation Progesterone-mediated oocyte maturation 0 0.803359684 0.75958816 kegg kegg NA NA no no no no no no Lysosome Progesterone-mediated oocyte maturation 0 -0.564229249 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Progesterone-mediated oocyte maturation 0 0.592885375 0.677734878 kegg kegg NA NA no no no no no no MAPK signaling pathway Progesterone-mediated oocyte maturation 0.663478261 0.721343874 0.58043758 kegg kegg NA NA no no no no no no Mitophagy - animal Progesterone-mediated oocyte maturation 0 0 -0.454311454 kegg kegg NA NA no no no no no no mRNA surveillance pathway Progesterone-mediated oocyte maturation 0 0 0.685456885 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Progesterone-mediated oocyte maturation 0 0.663043478 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Progesterone-mediated oocyte maturation 0 0 0.600514801 kegg kegg NA NA no no no no no no Necroptosis Progesterone-mediated oocyte maturation 0 0 -0.600772201 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Progesterone-mediated oocyte maturation 0 0 -0.528185328 kegg kegg NA NA no no no no no no Nitrogen metabolism Progesterone-mediated oocyte maturation 0 0 -0.476190476 kegg kegg NA NA no no no no no no Notch signaling pathway Progesterone-mediated oocyte maturation 0 0.467391304 0.652509653 kegg kegg NA NA no no no no no no Nucleotide excision repair Progesterone-mediated oocyte maturation 0 0.418972332 0.476705277 kegg kegg NA NA no no no no no no One carbon pool by folate Progesterone-mediated oocyte maturation 0 0 0.555469755 kegg kegg NA NA no no no no no no Oocyte meiosis Progesterone-mediated oocyte maturation 0.452173913 0 0.581724582 kegg kegg NA NA no no no no no no Oscillospira Progesterone-mediated oocyte maturation 0 0.601778656 0 LPS-producing Genus kegg 0.62 NA no no no no no no Other glycan degradation Progesterone-mediated oocyte maturation 0 0.623517787 0.62960103 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Progesterone-mediated oocyte maturation 0.453913043 0.795454545 0.796653797 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Progesterone-mediated oocyte maturation 0 0 -0.466409266 kegg kegg NA NA no up up no no no p53 signaling pathway Progesterone-mediated oocyte maturation 0.532173913 0.694664032 0.437580438 kegg kegg NA NA no no no no no no Pentose phosphate pathway Progesterone-mediated oocyte maturation 0 0 -0.464864865 kegg kegg NA NA no no no no no no Phagosome Progesterone-mediated oocyte maturation -0.460869565 0 -0.592535393 kegg kegg NA NA no no no no no no Phenylalanine metabolism Progesterone-mediated oocyte maturation -0.430434783 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Progesterone-mediated oocyte maturation 0.445217391 0.695652174 0.822651223 kegg kegg NA NA no no no no no no Phototransduction Progesterone-mediated oocyte maturation 0 -0.486166008 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Progesterone-mediated oocyte maturation 0.613043478 0 0 yes kegg kegg NA NA no up up no no no Platelet activation Progesterone-mediated oocyte maturation -0.602608696 -0.596837945 0 kegg kegg NA NA no no no no no no Platinum drug resistance Progesterone-mediated oocyte maturation 0.646956522 0.890316206 0.575289575 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Progesterone-mediated oocyte maturation -0.488695652 0 -0.701415701 kegg kegg NA NA no no no no no no Protein export Progesterone-mediated oocyte maturation 0.454782609 0 0.563449163 kegg kegg NA NA no no no no no no Purine metabolism Progesterone-mediated oocyte maturation 0 0 -0.453024453 kegg kegg NA NA no no no no no no Rap1 signaling pathway Progesterone-mediated oocyte maturation -0.5 -0.614624506 0 kegg kegg NA NA no no no no no no Ras signaling pathway Progesterone-mediated oocyte maturation 0 0 0.624967825 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Progesterone-mediated oocyte maturation -0.423478261 -0.564229249 0 kegg kegg NA NA no no no no no no Retinol metabolism Progesterone-mediated oocyte maturation 0 0 0.495238095 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Progesterone-mediated oocyte maturation 0.539130435 0.634387352 0.727670528 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Progesterone-mediated oocyte maturation 0.470434783 0 0 kegg kegg NA NA no no no no no no RNA degradation Progesterone-mediated oocyte maturation 0 0 0.725611326 kegg kegg NA NA no no no no no no RNA polymerase Progesterone-mediated oocyte maturation 0.472173913 0.43972332 0.549034749 kegg kegg NA NA no no no no no no RNA transport Progesterone-mediated oocyte maturation 0.426956522 0 0 kegg kegg NA NA no no no no no no Ruminococcus Progesterone-mediated oocyte maturation 0 -0.433384192 0 Genus kegg 0.0679 NA no no dn no no no Selenocompound metabolism Progesterone-mediated oocyte maturation 0.528695652 0.888339921 0.714028314 kegg kegg NA NA no no no no no no Serotonergic synapse Progesterone-mediated oocyte maturation 0 0 -0.647876448 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Progesterone-mediated oocyte maturation 0.586086957 0.668972332 0.810810811 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Progesterone-mediated oocyte maturation 0 0.510869565 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Progesterone-mediated oocyte maturation 0.464347826 0 0.644272844 kegg kegg NA NA no no no no no no Spliceosome Progesterone-mediated oocyte maturation 0.70173913 0.882411067 0.735392535 kegg kegg NA NA no no no no no no Steroid biosynthesis Progesterone-mediated oocyte maturation 0 0 0.473873874 kegg kegg NA NA no no no no no no Sulfur metabolism Progesterone-mediated oocyte maturation -0.566956522 0 -0.708622909 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Progesterone-mediated oocyte maturation 0 0.445652174 0.516859717 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Progesterone-mediated oocyte maturation 0.716521739 0.53458498 0.561647362 kegg kegg NA NA no no no no no no Taste transduction Progesterone-mediated oocyte maturation 0.42 0.513833992 0.783268983 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Progesterone-mediated oocyte maturation 0 0.693675889 0.555984556 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Progesterone-mediated oocyte maturation 0.533913043 0.483201581 0.609266409 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Progesterone-mediated oocyte maturation 0 0 0.585842986 kegg kegg NA NA no no no no no no Tight junction Progesterone-mediated oocyte maturation -0.691304348 -0.666007905 -0.558301158 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Progesterone-mediated oocyte maturation 0 0 -0.438352638 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Progesterone-mediated oocyte maturation 0.580869565 0 0.658687259 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Progesterone-mediated oocyte maturation 0 -0.444664032 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Progesterone-mediated oocyte maturation 0.469565217 0 0.635521236 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Progesterone-mediated oocyte maturation 0 -0.649209486 -0.517889318 kegg kegg NA NA no no no no no no Wnt signaling pathway Progesterone-mediated oocyte maturation 0 0 0.732303732 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Prolactin signaling pathway -0.56173913 -0.57312253 0 kegg kegg NA NA no no no no no no Adherens junction Prolactin signaling pathway 0 -0.476284585 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Prolactin signaling pathway 0 -0.656126482 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Prolactin signaling pathway 0 0.640316206 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Prolactin signaling pathway 0 0.490118577 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Prolactin signaling pathway -0.506086957 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Prolactin signaling pathway -0.412173913 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Prolactin signaling pathway 0 -0.772727273 -0.450965251 kegg kegg NA NA no no no no no no Apoptosis Prolactin signaling pathway 0 0.77173913 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Prolactin signaling pathway -0.573043478 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Prolactin signaling pathway 0 0.599802372 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Prolactin signaling pathway 0 0.62055336 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Prolactin signaling pathway -0.466956522 -0.482213439 0 kegg kegg NA NA no no no no no no Autophagy - animal Prolactin signaling pathway 0.603478261 0.716403162 0.477992278 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Prolactin signaling pathway 0 0.767786561 0.493951094 kegg kegg NA NA no no no no no no Bacteroides Prolactin signaling pathway 0 -0.505928854 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Prolactin signaling pathway 0 -0.432806324 0 kegg kegg NA NA no no no no no no Base excision repair Prolactin signaling pathway 0 -0.442687747 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Prolactin signaling pathway -0.56173913 -0.432806324 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Prolactin signaling pathway 0 0.51284585 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Prolactin signaling pathway -0.627826087 -0.592885375 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Prolactin signaling pathway -0.486086957 0 -0.402059202 kegg kegg NA NA no no no no no no Butanoate metabolism Prolactin signaling pathway -0.676521739 -0.687747036 -0.567310167 kegg kegg NA NA no no no no no no Butyricimonas Prolactin signaling pathway 0.541322547 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no C-type lectin receptor signaling pathway Prolactin signaling pathway 0.653043478 0.828063241 0.642985843 kegg kegg NA NA no no no no no no cAMP signaling pathway Prolactin signaling pathway 0.539130435 0.476284585 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Prolactin signaling pathway -0.486956522 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Prolactin signaling pathway 0 -0.576086957 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Prolactin signaling pathway 0 0.443675889 0 kegg kegg NA NA no no no no no no Cell cycle Prolactin signaling pathway 0 -0.566205534 0 kegg kegg NA NA no no no no no no Cellular senescence Prolactin signaling pathway 0 0.627470356 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Prolactin signaling pathway 0.564347826 0.623517787 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Prolactin signaling pathway 0.41826087 0.570158103 0 kegg kegg NA NA no no no no no no Cholinergic synapse Prolactin signaling pathway 0.704347826 0 0 kegg kegg NA NA no no no no no no Circadian entrainment Prolactin signaling pathway 0 -0.548418972 0 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Prolactin signaling pathway -0.563478261 -0.77173913 0 kegg kegg NA NA no no no no no no Collinsella Prolactin signaling pathway 0 0 -0.41335855 Genus kegg 0.128 NA no no no no no no Complement and coagulation cascades Prolactin signaling pathway 0 0.551383399 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Prolactin signaling pathway -0.412173913 -0.707509881 -0.487001287 kegg kegg NA NA no no no no no no DNA replication Prolactin signaling pathway 0 -0.760869565 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Prolactin signaling pathway 0 -0.695652174 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Prolactin signaling pathway -0.436521739 -0.831027668 -0.508108108 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Prolactin signaling pathway -0.569565217 -0.730237154 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Prolactin signaling pathway -0.482608696 -0.509881423 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Prolactin signaling pathway 0 -0.609683794 0 kegg kegg NA NA no no no no no no Endocytosis Prolactin signaling pathway 0 0.496047431 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Prolactin signaling pathway 0.643478261 0.585968379 0.496010296 kegg kegg NA NA no no no no no no Estrogen signaling pathway Prolactin signaling pathway 0 -0.624505929 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Prolactin signaling pathway 0 -0.456521739 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Prolactin signaling pathway 0.487826087 0.733201581 0.616216216 kegg kegg NA NA no no no no no no Fatty acid degradation Prolactin signaling pathway 0 0.479249012 0 kegg kegg NA NA no no no no no no Fatty acid elongation Prolactin signaling pathway -0.586086957 -0.455533597 -0.538223938 kegg kegg NA NA no no no no no no Fatty acid metabolism Prolactin signaling pathway 0 0.423913043 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Prolactin signaling pathway 0.723478261 0.841897233 0.522265122 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Prolactin signaling pathway 0 0.56916996 0 kegg kegg NA NA no no no no no no Focal adhesion Prolactin signaling pathway 0 -0.508893281 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Prolactin signaling pathway 0.45826087 0.595849802 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Prolactin signaling pathway -0.413043478 0.51284585 0 kegg kegg NA NA no no no no no no Galactose metabolism Prolactin signaling pathway 0 0.636363636 0 kegg kegg NA NA no no no no no no Glutathione metabolism Prolactin signaling pathway -0.495652174 -0.697628458 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Prolactin signaling pathway 0 0.445652174 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Prolactin signaling pathway -0.488695652 -0.43083004 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Prolactin signaling pathway -0.555652174 -0.56916996 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Prolactin signaling pathway 0.500869565 0.791501976 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Prolactin signaling pathway -0.496521739 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Prolactin signaling pathway 0 -0.443675889 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Prolactin signaling pathway 0 0.414031621 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Prolactin signaling pathway 0 0.625494071 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Prolactin signaling pathway 0 -0.608695652 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Prolactin signaling pathway 0 -0.518774704 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Prolactin signaling pathway 0 0.519762846 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Prolactin signaling pathway 0.405217391 0.650197628 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Prolactin signaling pathway 0 -0.56916996 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Prolactin signaling pathway 0 -0.710474308 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Prolactin signaling pathway 0 0.695652174 0.547747748 kegg kegg NA NA no no no no no no Linoleic acid metabolism Prolactin signaling pathway -0.536521739 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Prolactin signaling pathway 0 -0.665019763 0 kegg kegg NA NA no no up no no no Lysosome Prolactin signaling pathway 0 0.427865613 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Prolactin signaling pathway 0 0 0.495238095 kegg kegg NA NA no no no no no no Melanogenesis Prolactin signaling pathway 0 -0.583992095 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Prolactin signaling pathway -0.443478261 -0.795454545 -0.527670528 kegg kegg NA NA no no no no no no Mismatch repair Prolactin signaling pathway -0.573043478 -0.739130435 -0.457400257 kegg kegg NA NA no no no no no no Mitophagy - animal Prolactin signaling pathway 0 -0.447628458 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Prolactin signaling pathway 0 -0.542490119 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Prolactin signaling pathway 0 -0.603754941 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Prolactin signaling pathway 0 -0.684782609 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Prolactin signaling pathway 0 0.566205534 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Prolactin signaling pathway 0 0.420948617 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Prolactin signaling pathway 0.474782609 0.637351779 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Prolactin signaling pathway 0 0.555335968 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Prolactin signaling pathway 0 0.739130435 0.62985843 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Prolactin signaling pathway 0 0.7243083 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Prolactin signaling pathway 0 0.545454545 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Prolactin signaling pathway 0 0.759881423 0.507078507 kegg kegg NA NA no no no no no no Non-homologous end-joining Prolactin signaling pathway -0.526086957 -0.544466403 -0.428571429 kegg kegg NA NA no no no no no no Notch signaling pathway Prolactin signaling pathway 0.486956522 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Prolactin signaling pathway -0.424347826 -0.720355731 0 kegg kegg NA NA no no no no no no Olfactory transduction Prolactin signaling pathway 0 0.433794466 0 kegg kegg NA NA no no no no no no One carbon pool by folate Prolactin signaling pathway 0 -0.598814229 0 kegg kegg NA NA no no no no no no Oocyte meiosis Prolactin signaling pathway 0 -0.707509881 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Prolactin signaling pathway 0 0.829051383 0.493693694 kegg kegg NA NA no no no no no no Oxidative phosphorylation Prolactin signaling pathway 0 -0.623517787 -0.403603604 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Prolactin signaling pathway 0 0.632411067 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Prolactin signaling pathway -0.706086957 -0.759881423 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Prolactin signaling pathway 0 0.571146245 0 kegg kegg NA NA no no no no no no Peroxisome Prolactin signaling pathway 0 0.579051383 0 kegg kegg NA NA no no no no no no Phagosome Prolactin signaling pathway 0 0.506916996 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Prolactin signaling pathway -0.506086957 -0.635375494 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Prolactin signaling pathway 0.551304348 0.669960474 0 kegg kegg NA NA no up up no no no Phototransduction Prolactin signaling pathway 0 -0.646245059 -0.527670528 kegg kegg NA NA no no no no no no Platelet activation Prolactin signaling pathway 0 -0.414031621 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Prolactin signaling pathway 0 0.660079051 0 kegg kegg NA NA no no no no no no Prevotella Prolactin signaling pathway 0 0.420766661 0 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Prolactin signaling pathway -0.605217391 -0.482213439 0 kegg kegg NA NA no no no no no no Propanoate metabolism Prolactin signaling pathway -0.417391304 -0.677865613 -0.488288288 kegg kegg NA NA no no no no no no Proteasome Prolactin signaling pathway 0 -0.581027668 0 kegg kegg NA NA no no no no no no Protein export Prolactin signaling pathway 0 -0.748023715 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Prolactin signaling pathway -0.436521739 -0.756916996 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Prolactin signaling pathway -0.413043478 -0.630434783 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Prolactin signaling pathway -0.467826087 -0.752964427 -0.526898327 kegg kegg NA NA no no no no no no Ras signaling pathway Prolactin signaling pathway 0 -0.687747036 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Prolactin signaling pathway 0 -0.527667984 -0.536422136 kegg kegg NA NA no no no no no no Renin-angiotensin system Prolactin signaling pathway 0 0.583992095 0 kegg kegg NA NA no no no no no no Retinol metabolism Prolactin signaling pathway 0 -0.527667984 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Prolactin signaling pathway 0 -0.747035573 0 kegg kegg NA NA no no up no no no Ribosome Prolactin signaling pathway 0 -0.648221344 -0.505791506 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Prolactin signaling pathway 0 -0.472332016 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Prolactin signaling pathway 0.50173913 0.710474308 0.55958816 kegg kegg NA NA no no no no no no RNA degradation Prolactin signaling pathway 0 -0.617588933 0 kegg kegg NA NA no no no no no no RNA polymerase Prolactin signaling pathway 0 -0.600790514 0 kegg kegg NA NA no no no no no no RNA transport Prolactin signaling pathway -0.451304348 -0.552371542 0 kegg kegg NA NA no no no no no no Sarcina Prolactin signaling pathway 0 0.422326513 0 Genus kegg 0.0703 NA no no no no no no Signaling pathways regulating pluripotency of stem cells Prolactin signaling pathway 0.536521739 0 0.402059202 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Prolactin signaling pathway 0.739130435 0.518774704 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Prolactin signaling pathway 0 0.675889328 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Prolactin signaling pathway 0 -0.568181818 -0.426512227 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Prolactin signaling pathway -0.611304348 -0.526679842 0 kegg kegg NA NA no no no no no no Sulfur metabolism Prolactin signaling pathway -0.615652174 -0.511857708 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Prolactin signaling pathway 0.415652174 0.480237154 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Prolactin signaling pathway -0.41826087 -0.603754941 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Prolactin signaling pathway 0 0.441699605 0 kegg kegg NA NA no no no no no no Taste transduction Prolactin signaling pathway 0 -0.533596838 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Prolactin signaling pathway 0 0.454545455 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Prolactin signaling pathway 0 -0.65513834 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Prolactin signaling pathway 0 0.515810277 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Prolactin signaling pathway 0 0.515810277 0 kegg kegg NA NA no no no no no no Thermogenesis Prolactin signaling pathway 0 -0.67687747 -0.55958816 kegg kegg NA NA no no no no no no Thiamine metabolism Prolactin signaling pathway 0 -0.677865613 0 kegg kegg NA NA no no no no no no Tight junction Prolactin signaling pathway 0 -0.489130435 -0.42960103 kegg kegg NA NA no no no no no no TNF signaling pathway Prolactin signaling pathway 0.584347826 0.754940711 0.534877735 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Prolactin signaling pathway 0.659130435 0.804347826 0.4996139 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Prolactin signaling pathway -0.617391304 -0.587944664 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Prolactin signaling pathway -0.497391304 -0.678853755 -0.494980695 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Prolactin signaling pathway -0.653913043 -0.663043478 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Prolactin signaling pathway 0 -0.554347826 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Prolactin signaling pathway -0.64173913 -0.690711462 -0.439382239 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Prolactin signaling pathway 0 -0.555335968 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Prolactin signaling pathway 0 -0.666996047 -0.428056628 kegg kegg NA NA no no no no no no VEGF signaling pathway Prolactin signaling pathway 0.76173913 0.614624506 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Prolactin signaling pathway 0 -0.605731225 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Propanoate metabolism 0 -0.539525692 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Propanoate metabolism 0.477391304 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Propanoate metabolism 0.665217391 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Propanoate metabolism 0 -0.581027668 -0.453539254 kegg kegg NA NA no up no no no no Arginine biosynthesis Propanoate metabolism 0 -0.530632411 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Propanoate metabolism 0.506956522 0.623517787 0.501415701 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Propanoate metabolism 0.727826087 0.855731225 0.587644788 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Propanoate metabolism 0.946956522 0.986166008 0.943886744 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Propanoate metabolism 0 -0.520750988 0 kegg kegg NA NA no no no no no no Fatty acid degradation Propanoate metabolism 0.475652174 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Propanoate metabolism 0.47826087 0.722332016 0.657142857 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Propanoate metabolism 0 -0.584980237 0 kegg kegg NA NA no no no no no no Glutathione metabolism Propanoate metabolism 0 0.559288538 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Propanoate metabolism 0 -0.437747036 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Propanoate metabolism 0.733043478 0.860671937 0.465379665 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Propanoate metabolism 0 -0.817193676 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Propanoate metabolism -0.629565217 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Propanoate metabolism -0.426086957 -0.440711462 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Propanoate metabolism -0.706086957 -0.572134387 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Propanoate metabolism 0 -0.502964427 0 kegg kegg NA NA no no no no no no Histidine metabolism Propanoate metabolism 0.415652174 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Propanoate metabolism -0.546956522 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Propanoate metabolism 0.749565217 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Propanoate metabolism 0 0.611660079 0.434234234 kegg kegg NA NA no no no no no no Other glycan degradation Propanoate metabolism 0 -0.450592885 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Propanoate metabolism 0 0.43972332 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Propanoate metabolism 0.695652174 0.744071146 0.515315315 kegg kegg NA NA no no no no no no Phenylalanine metabolism Propanoate metabolism 0 0.660079051 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Propanoate metabolism 0.712173913 0.72826087 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Propanoate metabolism 0.553043478 0.492094862 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Propanoate metabolism 0.932173913 0.967391304 0.87001287 kegg kegg NA NA no no no no no no Sphingolipid metabolism Propanoate metabolism -0.48173913 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Propanoate metabolism 0 -0.493083004 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Propanoate metabolism 0 0.705533597 0.525353925 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Propanoate metabolism 0.622608696 0.619565217 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Propanoate metabolism 0.817391304 0.701581028 0.605405405 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Propanoate metabolism 0 -0.578063241 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Propanoate metabolism 0.666086957 0.760869565 0.562676963 kegg kegg NA NA no up no no no no Tyrosine metabolism Propanoate metabolism 0.679130435 0.773715415 0.568854569 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Propanoate metabolism 0.648695652 0.645256917 0.585585586 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Propanoate metabolism 0.760869565 0.72826087 0.724324324 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Propanoate metabolism 0 0.517786561 0.421621622 kegg kegg NA NA no no no no no no 14:0/16:0-PC+blood propionic acid C3+blood 0 -0.588235294 0 serum_phospholipids serum_scfa 0.0358 0.104 no up no no dn no 14:0/18:2-PC+blood propionic acid C3+blood 0 0 -0.404444444 serum_phospholipids serum_scfa 0.102 0.104 no up no no dn no 16:0/18:3-PC+blood propionic acid C3+blood 0 -0.487745098 0 serum_phospholipids serum_scfa 0.00216 0.104 no up up no dn no 16:0/20:5-PG+blood propionic acid C3+blood 0 0 0.526153846 serum_phospholipids serum_scfa 0.00656 0.104 no up no no dn no 18:0/18:0-PC+blood propionic acid C3+blood 0.506766917 0 0 serum_phospholipids serum_scfa 0.426 0.104 no no no no dn no 18:0/20:2-PC+blood propionic acid C3+blood 0 0 -0.446153846 serum_phospholipids serum_scfa 0.733 0.104 no no no no dn no 18:0+blood propionic acid C3+blood 0.45112782 0 0 serum_fattyacid serum_scfa 0.344 0.104 no no no no dn no 18:1-LPC+blood propionic acid C3+blood 0 0.710784314 0 serum_phospholipids serum_scfa 0.179 0.104 no no no no dn no 18:1/18:2-PI+blood propionic acid C3+blood -0.541353383 0 0 serum_phospholipids serum_scfa 0.0164 0.104 dn no up no dn no 18:2/18:2-PS+blood propionic acid C3+blood 0 0 0.468034188 serum_phospholipids serum_scfa 0.00674 0.104 up up no no dn no 18:3/18:2-PC+blood propionic acid C3+blood 0 0 -0.406495726 serum_phospholipids serum_scfa 0.0394 0.104 no no up no dn no 2-methyl-butyric acid m-C4+blood propionic acid C3+blood 0.551879699 0 0.556239316 serum_scfa serum_scfa 0.262 0.104 no no no no dn no 20:0-LPC+blood propionic acid C3+blood 0 0.568627451 -0.418803419 serum_phospholipids serum_scfa 0.199 0.104 no no no no dn no 20:1-LPC+blood propionic acid C3+blood 0 0.735294118 0 serum_phospholipids serum_scfa 0.217 0.104 no no no no dn no 20:2-LPC+blood propionic acid C3+blood -0.494736842 0 0 serum_phospholipids serum_scfa 0.119 0.104 no no up no dn no 22:2-LPA+blood propionic acid C3+blood -0.584962406 0 0 serum_phospholipids serum_scfa 0.0443 0.104 dn no no no dn no 9-HODE+blood propionic acid C3+blood -0.571428571 0 0 serum_ARA serum_scfa 0.297 0.104 no no no no dn no acetic acid C2+blood propionic acid C3+blood 0.694736842 0.514705882 0 serum_scfa serum_scfa 0.000193 0.104 up dn no no dn no butyric acid C4+blood propionic acid C3+blood 0.613533835 0 0.688888889 serum_scfa serum_scfa 0.407 0.104 no no no no dn no d18:0-16:0-SM+blood propionic acid C3+blood 0 0 0.401709402 serum_phospholipids serum_scfa 0.202 0.104 no no no no dn no d18:1-16:0-SM+blood propionic acid C3+blood 0 0 0.417435897 serum_phospholipids serum_scfa 0.14 0.104 no no no no dn no d18:1-18:0-SM+blood propionic acid C3+blood 0 0 0.437948718 serum_phospholipids serum_scfa 0.97 0.104 no no no no dn no d18:1-18:1-SM+blood propionic acid C3+blood 0 0 0.496068376 serum_phospholipids serum_scfa 0.916 0.104 no no no no dn no d18:1-20:1-SM+blood propionic acid C3+blood 0 0.517156863 0 serum_phospholipids serum_scfa 0.0992 0.104 no no no no dn no decanoic acid C10+blood propionic acid C3+blood 0.463157895 0 0 serum_mcfa serum_scfa 6.64E-11 0.104 dn dn no no dn no heptanoic acid C7+blood propionic acid C3+blood 0.709774436 0 0.402393162 serum_mcfa serum_scfa 8.27E-11 0.104 dn dn no no dn no iso-LCA+blood propionic acid C3+blood 0 0.676820944 0 serum_bileacids serum_scfa 0.507 0.104 no no no no dn no isobutyric acid C4+blood propionic acid C3+blood 0.637593985 0 0.757264957 serum_scfa serum_scfa 0.0151 0.104 up up no no dn no isovaleric acid iso-C5+blood propionic acid C3+blood 0 0 0.426324786 serum_scfa serum_scfa 0.117 0.104 no no no no dn no L-Ornithine+blood propionic acid C3+blood 0 0.522058824 0 serum_aminoacids serum_scfa 0.175 0.104 no no no no dn no nonanoic acid C9+blood propionic acid C3+blood 0.645112782 0 0 serum_mcfa serum_scfa 6.51E-11 0.104 dn dn no no dn no octanoic acid C8+blood propionic acid C3+blood 0.660150376 0 0 serum_mcfa serum_scfa 2.84E-11 0.104 dn dn dn no dn no 5-Hydroxytryptamine+stool Propionic acid+stool -0.581011352 0 -0.638339921 yes stool_cometabolism stool_scfa 0.00862 0.0436 dn dn no dn no up Acetic acid+stool Propionic acid+stool 0.7750258 0 0.769762846 yes yes stool_scfa stool_scfa 0.0656 0.0436 dn no no dn no up Anaerostipes Propionic acid+stool 0 0.598606393 0 butyrate-producing yes Genus stool_scfa 0.568 0.0436 no no no dn no up Apelin signaling pathway Propionic acid+stool 0.578947368 0 0 yes kegg stool_scfa NA 0.0436 no no no dn no up Butyric acid+stool Propionic acid+stool 0.512899897 0 0.609683794 yes yes stool_scfa stool_scfa 0.102 0.0436 dn no no dn no up CA+stool Propionic acid+stool -0.564499484 0 0 yes stool_bileacids stool_scfa 0.827 0.0436 no no no dn no up Chemokine signaling pathway Propionic acid+stool -0.566563467 0 0 yes kegg stool_scfa NA 0.0436 no no no dn no up Coprococcus Propionic acid+stool 0 -0.622377622 0 butyrate-producing yes Genus stool_scfa 0.612 0.0436 no no no dn no up DCA+stool Propionic acid+stool 0 0 0.56027668 yes stool_bileacids stool_scfa 0.195 0.0436 no no no dn no up EGFR tyrosine kinase inhibitor resistance Propionic acid+stool 0.622291022 0 0 yes kegg stool_scfa NA 0.0436 no no no dn no up Epithelial cell signaling in Helicobacter pylori infection Propionic acid+stool -0.488132095 0 0 yes kegg stool_scfa NA 0.0436 no no no dn no up GCA+stool Propionic acid+stool -0.479876161 0 0 yes stool_bileacids stool_scfa 0.0809 0.0436 no no no dn no up GCDCA+stool Propionic acid+stool -0.494324045 0 0 yes yes stool_bileacids stool_scfa 0.0471 0.0436 no dn no dn no up GDCA+stool Propionic acid+stool -0.494579312 0 -0.521266328 yes stool_bileacids stool_scfa 0.656 0.0436 no no no dn no up HIF-1 signaling pathway Propionic acid+stool 0.547987616 0 0 yes kegg stool_scfa NA 0.0436 no no no dn no up Inflammatory bowel disease Propionic acid+stool 0 -0.618181818 0 yes kegg stool_scfa NA 0.0436 no no no dn no up Insulin signaling pathway Propionic acid+stool 0.568627451 0 0 yes kegg stool_scfa NA 0.0436 no no no dn no up iso-DCA+stool Propionic acid+stool 0 0.734265734 0 yes stool_bileacids stool_scfa 0.155 0.0436 no no no dn no up mTOR signaling pathway Propionic acid+stool 0.585139319 0 0 yes kegg stool_scfa NA 0.0436 no no no dn no up PI3K-Akt signaling pathway Propionic acid+stool 0 0.618181818 0 yes yes kegg stool_scfa NA 0.0436 no up up dn no up Renal cell carcinoma Propionic acid+stool 0 0.663636364 0 yes kegg stool_scfa NA 0.0436 no no no dn no up Ribosome biogenesis in eukaryotes Propionic acid+stool 0.469556244 0 0 yes kegg stool_scfa NA 0.0436 no no no dn no up ¦Ø-MCA+stool Propionic acid+stool -0.640115782 0 0 yes stool_bileacids stool_scfa 0.919 0.0436 no no no dn no up 2-Oxocarboxylic acid metabolism Prostate cancer -0.595652174 -0.446640316 0 kegg kegg NA NA no no no no no no Adherens junction Prostate cancer -0.405217391 -0.532608696 -0.423680824 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Prostate cancer 0 0.725296443 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Prostate cancer 0 0.577075099 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Prostate cancer 0 0.491106719 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Prostate cancer 0.667826087 0.623517787 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Prostate cancer -0.553043478 0 -0.41003861 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Prostate cancer 0 -0.450592885 0 kegg kegg NA NA no no no no no no Amoebiasis Prostate cancer 0 0.511857708 0 kegg kegg NA NA no no no no no no Amphetamine addiction Prostate cancer 0 -0.572134387 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Prostate cancer 0 -0.443675889 0 kegg kegg NA NA no no no no no no Anaerostipes Prostate cancer 0 0 -0.444219351 butyrate-producing Genus kegg 0.568 NA no no no no no no Apelin signaling pathway Prostate cancer 0 -0.482213439 0 kegg kegg NA NA no no no no no no Apoptosis Prostate cancer 0 0.706521739 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Prostate cancer -0.657391304 0 -0.448648649 kegg kegg NA NA no no no no no no Arginine and proline metabolism Prostate cancer 0 0.558300395 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Prostate cancer 0 0.475296443 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Prostate cancer 0 -0.419960474 0 kegg kegg NA NA no no no no no no Autophagy - animal Prostate cancer 0.673913043 0.773715415 0 kegg kegg NA NA no no no no no no Autophagy - other Prostate cancer 0.668695652 0.517786561 0.523552124 kegg kegg NA NA no no no no no no Axon guidance Prostate cancer 0.693043478 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Prostate cancer 0.602608696 0.856719368 0.725353925 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Prostate cancer -0.457391304 -0.480237154 -0.565250965 kegg kegg NA NA no no no no no no Basal transcription factors Prostate cancer 0 -0.414031621 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Prostate cancer -0.67826087 -0.635375494 -0.729214929 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Prostate cancer -0.456521739 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Prostate cancer -0.56173913 -0.557312253 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Prostate cancer -0.552173913 -0.694664032 -0.701673102 kegg kegg NA NA no no no no no no Butanoate metabolism Prostate cancer -0.59826087 -0.726284585 -0.590733591 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Prostate cancer 0.853043478 0.887351779 0.854826255 kegg kegg NA NA no no no no no no Calcium signaling pathway Prostate cancer 0 0 0.505534106 kegg kegg NA NA no up up no no no cAMP signaling pathway Prostate cancer 0.636521739 0.731225296 0.670527671 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Prostate cancer 0.724347826 0.672924901 0 kegg kegg NA NA no no no no no no Carbon metabolism Prostate cancer -0.599130435 0 -0.451737452 kegg kegg NA NA no no no no no no Cell cycle Prostate cancer 0 -0.448616601 0 kegg kegg NA NA no no no no no no Cellular senescence Prostate cancer 0 0.579051383 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Prostate cancer 0.407826087 0 0 kegg kegg NA NA no no no no no no Chagas disease Prostate cancer 0.633043478 0.811264822 0.521235521 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Prostate cancer -0.47826087 0 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Prostate cancer 0.451304348 0.545454545 0 kegg kegg NA NA no no no no no no Cholinergic synapse Prostate cancer 0.507826087 0 0.430888031 kegg kegg NA NA no no no no no no Circadian entrainment Prostate cancer 0 -0.73715415 0 kegg kegg NA NA no up up no no no Circadian rhythm Prostate cancer 0.653043478 0 0.482882883 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Prostate cancer -0.586956522 -0.75 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Prostate cancer 0 -0.540513834 -0.47027027 kegg kegg NA NA no no no no no no Collinsella Prostate cancer 0 0 -0.40004125 Genus kegg 0.128 NA no no no no no no Colorectal cancer Prostate cancer 0.665217391 0 0.465379665 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Prostate cancer 0 -0.701581028 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Prostate cancer 0 0 -0.468211068 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Prostate cancer 0 0.850790514 0.541827542 kegg kegg NA NA no no no no no no DNA replication Prostate cancer 0 -0.716403162 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Prostate cancer 0 -0.56027668 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Prostate cancer -0.414782609 -0.751976285 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Prostate cancer -0.696521739 -0.663043478 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Prostate cancer 0 -0.425889328 0 kegg kegg NA NA no up up no no no Endometrial cancer Prostate cancer 0.82173913 0.875494071 0.691377091 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Prostate cancer 0.429565217 0.693675889 0.486486486 kegg kegg NA NA no no no no no no ErbB signaling pathway Prostate cancer 0.714782609 0.659090909 0.469498069 kegg kegg NA NA no no no no no no Estrogen signaling pathway Prostate cancer 0 -0.815217391 -0.457915058 kegg kegg NA NA no no no no no no Ether lipid metabolism Prostate cancer 0 -0.419960474 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Prostate cancer 0 0.453557312 0 kegg kegg NA NA no no no no no no Fatty acid elongation Prostate cancer -0.62 -0.597826087 -0.652252252 kegg kegg NA NA no no no no no no Fatty acid metabolism Prostate cancer 0 0 -0.401544402 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Prostate cancer 0.52 0.679841897 0 kegg kegg NA NA no no no no no no Focal adhesion Prostate cancer -0.42 -0.615612648 -0.494208494 kegg kegg NA NA no up up no no no Fructose and mannose metabolism Prostate cancer -0.450434783 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Prostate cancer -0.463478261 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Prostate cancer -0.506086957 -0.617588933 -0.456628057 kegg kegg NA NA no no no no no no Glioma Prostate cancer 0.553043478 0 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Prostate cancer 0 -0.5 0 kegg kegg NA NA no no no no no no Glutathione metabolism Prostate cancer -0.511304348 -0.514822134 -0.442471042 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Prostate cancer -0.457391304 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Prostate cancer -0.643478261 -0.590909091 -0.611840412 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Prostate cancer 0 0.708498024 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Prostate cancer -0.487826087 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Prostate cancer 0 -0.457509881 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Prostate cancer 0.52173913 0.526679842 0.52020592 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Prostate cancer 0 0.496047431 0 kegg kegg NA NA no no no no no no GnRH secretion Prostate cancer 0.692173913 0.68972332 0.40952381 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Prostate cancer 0.415652174 0 0.446332046 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Prostate cancer -0.439130435 -0.444664032 -0.547490347 kegg kegg NA NA no no no no no no Hepatitis B Prostate cancer 0.793043478 0.787549407 0.863063063 kegg kegg NA NA no no no no no no Hepatitis C Prostate cancer 0.744347826 0.880434783 0.837065637 kegg kegg NA NA no no no no no no Hippo signaling pathway Prostate cancer -0.468695652 -0.540513834 -0.456113256 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Prostate cancer 0 0.446640316 0 kegg kegg NA NA no no no no no no Histidine metabolism Prostate cancer -0.486956522 0 -0.494723295 kegg kegg NA NA no no no no no no Human papillomavirus infection Prostate cancer 0 0.604743083 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Prostate cancer 0 -0.526679842 0 kegg kegg NA NA no no no no no no Insulin resistance Prostate cancer 0.834782609 0.900197628 0.873616474 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Prostate cancer 0 0.600790514 0 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Prostate cancer 0.43826087 0 0 kegg kegg NA NA no no dn no no no Lachnospira Prostate cancer 0 -0.463553263 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Long-term potentiation Prostate cancer 0 -0.551383399 0 kegg kegg NA NA no no up no no no Longevity regulating pathway - multiple species Prostate cancer 0 0 -0.609009009 kegg kegg NA NA no no no no no no Lysine degradation Prostate cancer 0.497391304 0 0 kegg kegg NA NA no no no no no no Malaria Prostate cancer 0 0.416996047 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Prostate cancer 0.602608696 0 0 kegg kegg NA NA no no no no no no Measles Prostate cancer 0.52 0 0 kegg kegg NA NA no no no no no no Melanogenesis Prostate cancer 0 -0.437747036 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Prostate cancer -0.525217391 -0.77173913 -0.44015444 kegg kegg NA NA no no no no no no MicroRNAs in cancer Prostate cancer 0.573043478 0.867588933 0.523037323 kegg kegg NA NA no no no no no no Mismatch repair Prostate cancer -0.454782609 -0.787549407 -0.483655084 kegg kegg NA NA no no no no no no mRNA surveillance pathway Prostate cancer 0.58173913 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Prostate cancer 0 -0.503952569 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Prostate cancer 0 0.454545455 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Prostate cancer 0.910434783 0.961462451 0.890862291 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Prostate cancer 0.517391304 0.83201581 0.789446589 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Prostate cancer 0 0.464426877 0 kegg kegg NA NA no no no no no no Nicotine addiction Prostate cancer 0 0 0.579150579 kegg kegg NA NA no up up no no no Nitrogen metabolism Prostate cancer 0 0.488142292 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Prostate cancer 0 0.735177866 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Prostate cancer 0.42 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Prostate cancer -0.62 -0.709486166 -0.680823681 kegg kegg NA NA no no no no no no Notch signaling pathway Prostate cancer 0.450434783 0.440711462 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Prostate cancer 0 -0.750988142 0 kegg kegg NA NA no no no no no no One carbon pool by folate Prostate cancer 0 -0.744071146 0 kegg kegg NA NA no no no no no no Oocyte meiosis Prostate cancer 0 -0.658102767 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Prostate cancer 0 0.588932806 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Prostate cancer 0.445217391 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Prostate cancer 0 -0.414031621 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Prostate cancer -0.545217391 -0.450592885 -0.543371943 kegg kegg NA NA no no no no no no p53 signaling pathway Prostate cancer 0.446956522 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Prostate cancer 0.516521739 0 0 kegg kegg NA NA no no no no no no Paraprevotella Prostate cancer -0.457286941 0 0 Genus kegg 0.118 NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Prostate cancer 0.433043478 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Prostate cancer 0.629565217 0.636363636 0.528700129 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Prostate cancer -0.566086957 -0.636363636 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Prostate cancer -0.751304348 -0.745059289 -0.50990991 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Prostate cancer 0.450434783 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Prostate cancer 0 0.604743083 0 kegg kegg NA NA no up up no no no Phototransduction Prostate cancer 0 -0.697628458 0 kegg kegg NA NA no no no no no no Platelet activation Prostate cancer -0.54 -0.555335968 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Prostate cancer -0.483478261 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Prostate cancer 0 0.648221344 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Prostate cancer -0.566956522 -0.716403162 -0.620592021 kegg kegg NA NA no no no no no no Prion disease Prostate cancer 0 -0.462450593 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Prostate cancer 0.505217391 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Prostate cancer 0.48173913 0.677865613 0.468468468 kegg kegg NA NA no no no no no no Propanoate metabolism Prostate cancer -0.407826087 -0.685770751 0 kegg kegg NA NA no no no no no no Proteasome Prostate cancer 0 -0.595849802 0 kegg kegg NA NA no no no no no no Protein export Prostate cancer 0 -0.461462451 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Prostate cancer 0 -0.450592885 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Prostate cancer 0 -0.653162055 0 kegg kegg NA NA no no no no no no Pyramidobacter Prostate cancer 0 0 0.443003009 Genus kegg 0.45 NA no no no no no no Pyrimidine metabolism Prostate cancer -0.612173913 -0.72826087 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Prostate cancer -0.487826087 -0.704545455 -0.518404118 kegg kegg NA NA no no no no no no Ras signaling pathway Prostate cancer 0 -0.524703557 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Prostate cancer -0.45826087 -0.654150198 -0.574774775 kegg kegg NA NA no no no no no no Relaxin signaling pathway Prostate cancer 0.665217391 0.774703557 0.649163449 kegg kegg NA NA no no no no no no Renal cell carcinoma Prostate cancer 0.634782609 0 0 kegg kegg NA NA no no no no no no Renin secretion Prostate cancer -0.406956522 -0.666007905 0 kegg kegg NA NA no no no no no no Retinol metabolism Prostate cancer -0.585217391 -0.747035573 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Prostate cancer 0 -0.526679842 0 kegg kegg NA NA no no up no no no Ribosome biogenesis in eukaryotes Prostate cancer 0 -0.475296443 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Prostate cancer 0.73826087 0.852766798 0.853539254 kegg kegg NA NA no no no no no no RNA degradation Prostate cancer 0.545217391 0 0 kegg kegg NA NA no no no no no no RNA polymerase Prostate cancer 0 -0.48715415 0 kegg kegg NA NA no no no no no no Roseburia Prostate cancer -0.589565217 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Salivary secretion Prostate cancer 0 -0.494071146 0 kegg kegg NA NA no no no no no no Sarcina Prostate cancer 0 0.422326513 0 Genus kegg 0.0703 NA no no no no no no Signaling pathways regulating pluripotency of stem cells Prostate cancer 0.747826087 0.481225296 0.401544402 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Prostate cancer 0 0.517786561 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Prostate cancer 0.620869565 0.628458498 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Prostate cancer 0.643478261 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Prostate cancer 0 -0.850790514 -0.498069498 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Prostate cancer -0.595652174 -0.814229249 0 kegg kegg NA NA no no no no no no Sulfur metabolism Prostate cancer -0.48 -0.493083004 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Prostate cancer -0.444347826 -0.755928854 -0.460746461 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Prostate cancer 0.635652174 0.682806324 0 kegg kegg NA NA no no no no no no Taste transduction Prostate cancer 0 -0.658102767 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Prostate cancer 0 0.5 0.434749035 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Prostate cancer 0 -0.482213439 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Prostate cancer 0 -0.455533597 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Prostate cancer 0 0.533596838 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Prostate cancer 0 0.612648221 0 kegg kegg NA NA no no no no no no Thermogenesis Prostate cancer 0 -0.464426877 0 kegg kegg NA NA no no no no no no Thiamine metabolism Prostate cancer 0 -0.508893281 0 kegg kegg NA NA no no no no no no Tight junction Prostate cancer -0.489565217 -0.567193676 -0.652252252 kegg kegg NA NA no no no no no no TNF signaling pathway Prostate cancer 0.844347826 0.959486166 0.792277992 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Prostate cancer 0.665217391 0.821146245 0.614671815 yes kegg kegg NA NA no no no no no no Toxoplasmosis Prostate cancer 0 0 -0.421364221 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Prostate cancer 0.699130435 0.712450593 0.731531532 kegg kegg NA NA no no no no no no Tryptophan metabolism Prostate cancer -0.68173913 -0.760869565 -0.451737452 kegg kegg NA NA no up no no no no Type II diabetes mellitus Prostate cancer 0.759130435 0.710474308 0.405148005 kegg kegg NA NA no no no no no no Tyrosine metabolism Prostate cancer -0.840869565 -0.878458498 -0.809009009 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Prostate cancer -0.604347826 -0.760869565 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Prostate cancer -0.573913043 -0.767786561 -0.564221364 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Prostate cancer 0 -0.56027668 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Prostate cancer 0 -0.446640316 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Prostate cancer 0.72 0.661067194 0.41956242 kegg kegg NA NA no no no no no no Vibrio cholerae infection Prostate cancer -0.486956522 -0.539525692 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Prostate cancer 0 0.671936759 0.423938224 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Proteasome 0 0.612648221 0.490862291 kegg kegg NA NA no no no no no no ABC transporters Proteasome 0 -0.447628458 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" Proteasome 0 -0.603754941 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Proteasome 0 -0.434782609 0 kegg kegg NA NA no no no no no no Antifolate resistance Proteasome -0.424347826 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Proteasome 0 -0.615612648 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Proteasome 0 -0.590909091 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Proteasome 0 0.489130435 0.411840412 kegg kegg NA NA no no no no no no Basal transcription factors Proteasome 0.499130435 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Proteasome 0 0.543478261 0 kegg kegg NA NA no no no no no no Bifidobacterium Proteasome 0 0.482418517 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Biosynthesis of unsaturated fatty acids Proteasome 0 0.459486166 0 kegg kegg NA NA no no no no no no Butanoate metabolism Proteasome 0 0.700592885 0 kegg kegg NA NA no no no no no no Carbon metabolism Proteasome 0 0.533596838 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Proteasome 0 0.815217391 0.673101673 kegg kegg NA NA no no no no no no Clostridium Proteasome 0 0.606189257 0 Genus kegg 0.925 NA no no no no no no Cysteine and methionine metabolism Proteasome 0 0.740118577 0 kegg kegg NA NA no no no no no no DNA replication Proteasome 0 0.611660079 0.458687259 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Proteasome 0 0.731225296 0.41029601 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Proteasome 0 0.812252964 0.573487773 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Proteasome 0.412173913 0.490118577 0.501930502 kegg kegg NA NA no no no no no no Endocrine resistance Proteasome 0 -0.485177866 -0.736679537 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Proteasome 0 -0.631422925 0 kegg kegg NA NA no no no no no no Fatty acid degradation Proteasome 0 0 0.445817246 kegg kegg NA NA no no no no no no Fatty acid elongation Proteasome 0 0.565217391 0 kegg kegg NA NA no no no no no no Folate biosynthesis Proteasome 0 0.498023715 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Proteasome 0 -0.505928854 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Proteasome 0 -0.551383399 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Proteasome 0 -0.497035573 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Proteasome 0 0.804347826 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Proteasome 0 -0.818181818 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Proteasome 0 -0.554347826 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Proteasome 0 -0.422924901 0 kegg kegg NA NA no no no no no no Lachnospira Proteasome -0.494782609 0.447244886 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Proteasome 0 0.767786561 0.408751609 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Proteasome 0 0.575098814 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Proteasome 0 -0.643280632 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Proteasome 0 -0.622529644 0 kegg kegg NA NA no no no no no no Odoribacter Proteasome 0 0.443290116 0 butyrate-producing Genus kegg 0.798 NA no no no no no no One carbon pool by folate Proteasome 0 0.427865613 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Proteasome 0 0.502964427 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Proteasome 0 0.745059289 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Proteasome 0 0.606719368 0 kegg kegg NA NA no no no no no no Prevotella Proteasome 0 -0.477819767 -0.453503785 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Proteasome 0 0.686758893 0 kegg kegg NA NA no no no no no no Propanoate metabolism Proteasome 0 0.731225296 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Proteasome 0 0.475296443 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Proteasome 0 0.741106719 0 kegg kegg NA NA no no no no no no Retinol metabolism Proteasome 0 0 0.43963964 kegg kegg NA NA no no no no no no Ribosome Proteasome 0 0.532608696 0.433719434 kegg kegg NA NA no no no no no no RNA degradation Proteasome 0.433913043 0.5 0 kegg kegg NA NA no no no no no no RNA polymerase Proteasome 0 0.442687747 0 kegg kegg NA NA no no no no no no RNA transport Proteasome 0 0.535573123 0 kegg kegg NA NA no no no no no no Ruminococcus Proteasome 0.413155627 0 0 Genus kegg 0.0679 NA no no dn no no no Starch and sucrose metabolism Proteasome 0 -0.485177866 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Proteasome 0 0.633399209 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Proteasome 0 0.437747036 0 kegg kegg NA NA no no no no no no Sulfur metabolism Proteasome 0 0.451581028 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Proteasome 0 0.540513834 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Proteasome 0 -0.714426877 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Proteasome 0 0.467391304 0 kegg kegg NA NA no no no no no no Thiamine metabolism Proteasome 0 0.541501976 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Proteasome 0 0.722332016 0.487773488 kegg kegg NA NA no up no no no no Tyrosine metabolism Proteasome 0 0.530632411 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Proteasome 0 0.490118577 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Proteasome 0 0.625494071 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Proteasome 0 0.526679842 0 kegg kegg NA NA no no no no no no Adherens junction Protein digestion and absorption 0 -0.540513834 0 yes kegg kegg NA NA no no no no up up Adrenergic signaling in cardiomyocytes Protein digestion and absorption -0.635652174 -0.734189723 0 yes kegg kegg NA NA no no up no up up AGE-RAGE signaling pathway in diabetic complications Protein digestion and absorption 0.57826087 0.643280632 0.552123552 yes kegg kegg NA NA no no no no up up "Alanine, aspartate and glutamate metabolism" Protein digestion and absorption 0.576521739 0.564229249 0.438095238 yes kegg kegg NA NA no no no no up up Aldosterone synthesis and secretion Protein digestion and absorption -0.54173913 -0.750988142 -0.406949807 yes kegg kegg NA NA no up up no up up Aldosterone-regulated sodium reabsorption Protein digestion and absorption 0 0 0.771428571 yes kegg kegg NA NA no no no no up up alpha-Linolenic acid metabolism Protein digestion and absorption 0.52 0.542490119 0 yes kegg kegg NA NA no no no no up up Aminoacyl-tRNA biosynthesis Protein digestion and absorption 0.512173913 0 0 yes kegg kegg NA NA no no no no up up AMPK signaling pathway Protein digestion and absorption 0 -0.462450593 0 yes kegg kegg NA NA no no no no up up Apelin signaling pathway Protein digestion and absorption 0 -0.645256917 0 yes kegg kegg NA NA no no no no up up Apoptosis Protein digestion and absorption 0 0.564229249 0 yes kegg kegg NA NA no no no no up up Apoptosis - multiple species Protein digestion and absorption 0.432173913 0 0 yes kegg kegg NA NA no no no no up up Arginine and proline metabolism Protein digestion and absorption 0 0.595849802 0 yes kegg kegg NA NA no up no no up up Arginine biosynthesis Protein digestion and absorption 0.565217391 0.490118577 0 yes kegg kegg NA NA no no no no up up Autophagy - animal Protein digestion and absorption 0 0.606719368 0.688803089 yes kegg kegg NA NA no no no no up up Axon guidance Protein digestion and absorption -0.443478261 0 0 yes kegg kegg NA NA no up up no up up B cell receptor signaling pathway Protein digestion and absorption 0 0.540513834 0 yes kegg kegg NA NA no no no no up up beta-Alanine metabolism Protein digestion and absorption 0.574782609 0 0 yes kegg kegg NA NA no no no no up up Biosynthesis of amino acids Protein digestion and absorption 0.474782609 0.561264822 0 yes kegg kegg NA NA no no no no up up Biosynthesis of cofactors Protein digestion and absorption 0 -0.423913043 0 yes kegg kegg NA NA no no no no up up Biosynthesis of unsaturated fatty acids Protein digestion and absorption 0.429565217 0 0 yes kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway Protein digestion and absorption 0 0.593873518 0 yes kegg kegg NA NA no no no no up up Calcium signaling pathway Protein digestion and absorption -0.514782609 -0.735177866 0 yes kegg kegg NA NA no up up no up up cAMP signaling pathway Protein digestion and absorption -0.659130435 0 0 yes yes kegg kegg NA NA no up up no up up Carbohydrate digestion and absorption Protein digestion and absorption 0 0 0.673101673 yes kegg kegg NA NA no no no no up up Carbon metabolism Protein digestion and absorption 0.416521739 0 0 yes kegg kegg NA NA no no no no up up Cardiac muscle contraction Protein digestion and absorption -0.652173913 -0.835968379 -0.402316602 yes kegg kegg NA NA no no up no up up Cell adhesion molecules Protein digestion and absorption 0.431304348 0.526679842 0 yes kegg kegg NA NA no no no no up up Cellular senescence Protein digestion and absorption 0 0.47826087 0 yes kegg kegg NA NA no no no no up up cGMP-PKG signaling pathway Protein digestion and absorption 0 0.606719368 0 yes kegg kegg NA NA no no no no up up Circadian entrainment Protein digestion and absorption -0.551304348 -0.579051383 -0.547747748 yes kegg kegg NA NA no up up no up up Circadian rhythm Protein digestion and absorption -0.470434783 0 0 yes kegg kegg NA NA no no no no up up Complement and coagulation cascades Protein digestion and absorption 0 0.513833992 0 yes kegg kegg NA NA no no no no up up Cortisol synthesis and secretion Protein digestion and absorption -0.506086957 -0.516798419 0 yes kegg kegg NA NA no no up no up up Cushing syndrome Protein digestion and absorption -0.495652174 -0.53458498 0 yes kegg kegg NA NA no no up no up up Cytosolic DNA-sensing pathway Protein digestion and absorption -0.528695652 0 0 yes kegg kegg NA NA no no no no up up Dopaminergic synapse Protein digestion and absorption -0.693913043 -0.722332016 -0.474131274 yes kegg kegg NA NA no up no no up up Drug metabolism - cytochrome P450 Protein digestion and absorption 0 -0.418972332 0 yes kegg kegg NA NA no no no no up up EGFR tyrosine kinase inhibitor resistance Protein digestion and absorption 0 -0.553359684 0 yes kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Protein digestion and absorption -0.515652174 -0.848814229 -0.423938224 yes kegg kegg NA NA no no no no up up Endocytosis Protein digestion and absorption 0 0.543478261 0 yes kegg kegg NA NA no no no no up up ErbB signaling pathway Protein digestion and absorption 0 0 0.453796654 yes kegg kegg NA NA no no no no up up Ether lipid metabolism Protein digestion and absorption -0.589565217 0 0 yes kegg kegg NA NA no no no no up up Fatty acid biosynthesis Protein digestion and absorption 0.546956522 0.625494071 0.455598456 yes kegg kegg NA NA no no no no up up Fatty acid degradation Protein digestion and absorption 0.713913043 0.750988142 0 yes kegg kegg NA NA no no no no up up Fatty acid metabolism Protein digestion and absorption 0.743478261 0.726284585 0 yes kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway Protein digestion and absorption 0 0.656126482 0.586872587 yes kegg kegg NA NA no no no no up up Fc gamma R-mediated phagocytosis Protein digestion and absorption 0.485217391 0.664031621 0 yes kegg kegg NA NA no no no no up up Focal adhesion Protein digestion and absorption 0 -0.425889328 0 yes kegg kegg NA NA no up up no up up FoxO signaling pathway Protein digestion and absorption 0 0.610671937 0.438352638 yes kegg kegg NA NA no no no no up up Fructose and mannose metabolism Protein digestion and absorption 0 0.477272727 0 yes kegg kegg NA NA no no no no up up Galactose metabolism Protein digestion and absorption 0.553043478 0.628458498 0 yes kegg kegg NA NA no no no no up up Gastric acid secretion Protein digestion and absorption 0 -0.641304348 0 yes kegg kegg NA NA no no no no up up Glucagon signaling pathway Protein digestion and absorption -0.431304348 -0.719367589 0 yes kegg kegg NA NA no no no no up up Glutathione metabolism Protein digestion and absorption 0 -0.732213439 -0.41029601 yes kegg kegg NA NA no no no no up up Glycerolipid metabolism Protein digestion and absorption 0 0.463438735 0 yes kegg kegg NA NA no no up no up up "Glycine, serine and threonine metabolism" Protein digestion and absorption 0 -0.462450593 0 yes kegg kegg NA NA no up no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Protein digestion and absorption 0 0.612648221 0.422136422 yes kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate Protein digestion and absorption -0.41826087 0 0 yes kegg kegg NA NA no no no no up up Glycosaminoglycan degradation Protein digestion and absorption 0 0.564229249 0.409009009 yes kegg kegg NA NA no no up no up up Glyoxylate and dicarboxylate metabolism Protein digestion and absorption 0.682608696 0.524703557 0.412097812 yes kegg kegg NA NA no no no no up up GnRH secretion Protein digestion and absorption 0 0 0.415701416 yes kegg kegg NA NA no up up no up up GnRH signaling pathway Protein digestion and absorption -0.453043478 -0.502964427 0 yes kegg kegg NA NA no no no no up up Hematopoietic cell lineage Protein digestion and absorption 0.684347826 0 0 yes kegg kegg NA NA no no no no up up HIF-1 signaling pathway Protein digestion and absorption 0 -0.500988142 0 yes kegg kegg NA NA no no no no up up Hippo signaling pathway Protein digestion and absorption 0 -0.479249012 0 yes kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Protein digestion and absorption 0 0.635375494 0.49009009 yes kegg kegg NA NA no no no no up up Histidine metabolism Protein digestion and absorption 0.511304348 0.424901186 0.407207207 yes kegg kegg NA NA no no no no up up IL-17 signaling pathway Protein digestion and absorption 0 0.555335968 0 yes kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels Protein digestion and absorption -0.479130435 -0.670948617 0 yes kegg kegg NA NA no no no no up up Inositol phosphate metabolism Protein digestion and absorption 0.42 0.446640316 0 yes kegg kegg NA NA no no no no up up Insulin secretion Protein digestion and absorption 0 -0.593873518 0 yes yes kegg kegg NA NA no up up no up up Insulin signaling pathway Protein digestion and absorption 0 -0.566205534 0 yes kegg kegg NA NA no no no no up up JAK-STAT signaling pathway Protein digestion and absorption 0 0.561264822 0 yes kegg kegg NA NA no no no no up up Linoleic acid metabolism Protein digestion and absorption 0 -0.51284585 0 yes kegg kegg NA NA no no no no up up Long-term depression Protein digestion and absorption -0.53826087 0 0 yes kegg kegg NA NA no no no no up up Lysosome Protein digestion and absorption 0 0.483201581 0.442728443 yes kegg kegg NA NA no no no no up up MAPK signaling pathway Protein digestion and absorption 0 0.580039526 0 yes kegg kegg NA NA no no no no up up Melanogenesis Protein digestion and absorption -0.504347826 -0.750988142 -0.417760618 yes kegg kegg NA NA no no no no up up Mitophagy - animal Protein digestion and absorption -0.651304348 -0.805335968 -0.409009009 yes kegg kegg NA NA no no no no up up mRNA surveillance pathway Protein digestion and absorption -0.46 -0.489130435 0 yes kegg kegg NA NA no no no no up up mTOR signaling pathway Protein digestion and absorption 0 -0.52173913 0 yes kegg kegg NA NA no no no no up up Mucin type O-glycan biosynthesis Protein digestion and absorption 0 0.458498024 0 yes kegg kegg NA NA no no no no up up N-Glycan biosynthesis Protein digestion and absorption 0 -0.438735178 0 yes kegg kegg NA NA no no no no up up Natural killer cell mediated cytotoxicity Protein digestion and absorption 0 0.494071146 0 yes kegg kegg NA NA no no no no up up Necroptosis Protein digestion and absorption 0 -0.429841897 0 yes kegg kegg NA NA no no no no up up Neuroactive ligand-receptor interaction Protein digestion and absorption 0 0.575098814 0 yes kegg kegg NA NA up up up no up up Neurotrophin signaling pathway Protein digestion and absorption -0.439130435 0 0 yes kegg kegg NA NA no no no no up up Neutrophil extracellular trap formation Protein digestion and absorption 0 0.505928854 0 yes kegg kegg NA NA no no no no up up NF-kappa B signaling pathway Protein digestion and absorption 0.428695652 0.56027668 0 yes kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Protein digestion and absorption 0.544347826 0.614624506 0.438867439 yes kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Protein digestion and absorption 0.496521739 0.757905138 0 yes kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease Protein digestion and absorption -0.668695652 -0.79743083 -0.5001287 yes kegg kegg NA NA no no no no up up Non-homologous end-joining Protein digestion and absorption 0.506956522 0 0 yes kegg kegg NA NA no no no no up up Olfactory transduction Protein digestion and absorption 0 0.515810277 0 yes kegg kegg NA NA no no no no up up Osteoclast differentiation Protein digestion and absorption 0 0.739130435 0 yes kegg kegg NA NA no no no no up up Other glycan degradation Protein digestion and absorption 0 0.483201581 0 yes kegg kegg NA NA no no no no up up Ovarian steroidogenesis Protein digestion and absorption -0.443478261 -0.520750988 0 yes kegg kegg NA NA no up up no up up Oxidative phosphorylation Protein digestion and absorption -0.643478261 -0.839920949 -0.468211068 yes kegg kegg NA NA no no no no up up Pancreatic secretion Protein digestion and absorption -0.687826087 -0.751976285 0 yes kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis Protein digestion and absorption 0.417391304 0.716403162 0.546975547 yes kegg kegg NA NA no no dn no up up "Parathyroid hormone synthesis, secretion and action" Protein digestion and absorption -0.747826087 -0.694664032 -0.442471042 yes kegg kegg NA NA no no no no up up Pentose phosphate pathway Protein digestion and absorption 0 0.567193676 0 yes kegg kegg NA NA no no no no up up Peroxisome Protein digestion and absorption 0.669565217 0.643280632 0 yes kegg kegg NA NA no no no no up up Phagosome Protein digestion and absorption 0.423478261 0.5 0 yes kegg kegg NA NA no no no no up up Phototransduction Protein digestion and absorption 0 0 -0.405662806 yes kegg kegg NA NA no no no no up up Platelet activation Protein digestion and absorption 0 -0.479249012 0 yes kegg kegg NA NA no no no no up up Porphyrin and chlorophyll metabolism Protein digestion and absorption 0 -0.46541502 0 yes kegg kegg NA NA no no no no up up PPAR signaling pathway Protein digestion and absorption 0 0.592885375 0 yes kegg kegg NA NA no no no no up up Prolactin signaling pathway Protein digestion and absorption 0 0.640316206 0 yes kegg kegg NA NA no no no no up up Protein export Protein digestion and absorption 0 -0.51284585 0 yes kegg kegg NA NA no no no no up up Protein processing in endoplasmic reticulum Protein digestion and absorption 0 -0.5256917 -0.432432432 yes kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation Protein digestion and absorption 0 -0.471343874 0 yes kegg kegg NA NA no no no no up up Purine metabolism Protein digestion and absorption 0 -0.529644269 0 yes kegg kegg NA NA no no no no up up Pyrimidine metabolism Protein digestion and absorption 0.575652174 0 0 yes kegg kegg NA NA no no no no up up Pyruvate metabolism Protein digestion and absorption 0 -0.449604743 0 yes kegg kegg NA NA no no no no up up Ras signaling pathway Protein digestion and absorption 0 -0.443675889 0 yes yes kegg kegg NA NA no up up no up up Regulation of actin cytoskeleton Protein digestion and absorption 0 0 -0.411583012 yes kegg kegg NA NA no no no no up up Regulation of lipolysis in adipocytes Protein digestion and absorption -0.525217391 -0.575098814 0 yes kegg kegg NA NA no no no no up up Relaxin signaling pathway Protein digestion and absorption -0.70173913 0 0 yes kegg kegg NA NA no no no no up up Renin secretion Protein digestion and absorption -0.496521739 -0.713438735 0 yes kegg kegg NA NA no no no no up up Renin-angiotensin system Protein digestion and absorption 0 0.666996047 0.496267696 yes kegg kegg NA NA no no no no up up Retinol metabolism Protein digestion and absorption 0.408695652 0 0 yes kegg kegg NA NA no no no no up up Retrograde endocannabinoid signaling Protein digestion and absorption -0.599130435 -0.873517787 0 yes kegg kegg NA NA no no up no up up Ribosome Protein digestion and absorption -0.524347826 -0.731225296 -0.522007722 yes kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway Protein digestion and absorption 0 0.541501976 0 yes kegg kegg NA NA no no no no up up RNA degradation Protein digestion and absorption -0.439130435 -0.492094862 0 yes kegg kegg NA NA no no no no up up RNA polymerase Protein digestion and absorption 0 -0.444664032 0 yes kegg kegg NA NA no no no no up up Serotonergic synapse Protein digestion and absorption -0.489565217 0 0 yes kegg kegg NA NA no no no no up up SNARE interactions in vesicular transport Protein digestion and absorption 0 0.585968379 0 yes kegg kegg NA NA no no no no up up Sphingolipid metabolism Protein digestion and absorption 0 0 0.40952381 yes kegg kegg NA NA no no no no up up Sphingolipid signaling pathway Protein digestion and absorption 0 0.436758893 0.406177606 yes kegg kegg NA NA no no no no up up Starch and sucrose metabolism Protein digestion and absorption 0 0.711462451 0 yes kegg kegg NA NA no no no no up up Synaptic vesicle cycle Protein digestion and absorption 0 0.497035573 0 yes kegg kegg NA NA no up up no up up TGF-beta signaling pathway Protein digestion and absorption -0.446956522 -0.462450593 0 yes kegg kegg NA NA no no no no up up Th1 and Th2 cell differentiation Protein digestion and absorption 0 0.537549407 0 yes kegg kegg NA NA no no no no up up Th17 cell differentiation Protein digestion and absorption 0 0.56027668 0 yes kegg kegg NA NA no no no no up up Thermogenesis Protein digestion and absorption -0.666956522 -0.835968379 -0.56036036 yes kegg kegg NA NA no no no no up up Thyroid hormone signaling pathway Protein digestion and absorption 0 -0.57312253 0 yes kegg kegg NA NA no no no no up up Thyroid hormone synthesis Protein digestion and absorption -0.409565217 -0.714426877 -0.407207207 yes kegg kegg NA NA no no no no up up TNF signaling pathway Protein digestion and absorption 0 0.448616601 0 yes kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway Protein digestion and absorption 0 0.576086957 0 yes yes kegg kegg NA NA no no no no up up Tryptophan metabolism Protein digestion and absorption 0.491304348 0 0 yes kegg kegg NA NA no up no no up up Type I diabetes mellitus Protein digestion and absorption 0.426086957 0.469367589 0 yes kegg kegg NA NA no no no no up up Type II diabetes mellitus Protein digestion and absorption 0 0.493083004 0.574517375 yes kegg kegg NA NA no no no no up up Ubiquitin mediated proteolysis Protein digestion and absorption -0.645217391 -0.807312253 -0.433462033 yes kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" Protein digestion and absorption 0.406086957 0 0 yes kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Protein digestion and absorption -0.770434783 -0.773715415 -0.518661519 yes kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption Protein digestion and absorption -0.586086957 -0.817193676 -0.511454311 yes kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor Protein digestion and absorption 0 0 -0.487258687 yes kegg kegg NA NA no no no no up up Wnt signaling pathway Protein digestion and absorption -0.52 -0.523715415 0 yes kegg kegg NA NA no no no no up up 2-Oxocarboxylic acid metabolism Protein export 0 0.62944664 0 kegg kegg NA NA no no no no no no ABC transporters Protein export 0 -0.425889328 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" Protein export -0.416521739 -0.837944664 -0.651994852 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Protein export -0.533913043 -0.772727273 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Protein export 0 0 -0.577863578 kegg kegg NA NA no no no no no no Arginine and proline metabolism Protein export -0.448695652 -0.738142292 -0.490862291 kegg kegg NA NA no up no no no no Arginine biosynthesis Protein export -0.528695652 -0.81916996 -0.71016731 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Protein export 0 0.475296443 0 kegg kegg NA NA no no no no no no Basal transcription factors Protein export 0.817391304 0.458498024 0.608494208 kegg kegg NA NA no no no no no no beta-Alanine metabolism Protein export -0.435652174 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Protein export -0.689565217 -0.595849802 -0.642471042 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Protein export 0 0 -0.438095238 kegg kegg NA NA no no no no no no Butanoate metabolism Protein export 0 0.636363636 0 kegg kegg NA NA no no no no no no Carbon metabolism Protein export -0.465217391 0 -0.402316602 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Protein export 0 0.714426877 0.485971686 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Protein export 0 0.706521739 0.503217503 kegg kegg NA NA no no no no no no DNA replication Protein export 0.583478261 0.638339921 0.545945946 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Protein export 0 0.706521739 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Protein export 0 0.800395257 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Protein export 0.569565217 0.713438735 0.591763192 kegg kegg NA NA no no no no no no Ether lipid metabolism Protein export 0.543478261 0.496047431 0.487773488 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Protein export 0 -0.897233202 0 kegg kegg NA NA no no no no no no Fatty acid degradation Protein export 0 -0.711462451 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Protein export -0.444347826 -0.644268775 0 kegg kegg NA NA no no no no no no Folate biosynthesis Protein export 0 0.659090909 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Protein export -0.519130435 -0.592885375 0 kegg kegg NA NA no no no no no no Galactose metabolism Protein export -0.608695652 -0.744071146 0 kegg kegg NA NA no no no no no no Glutathione metabolism Protein export 0 0.636363636 -0.466151866 kegg kegg NA NA no no no no no no Glycerolipid metabolism Protein export 0 -0.618577075 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Protein export 0 -0.443675889 0.44041184 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Protein export 0 0 -0.461776062 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Protein export 0 0.618577075 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Protein export -0.625217391 -0.834980237 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Protein export 0 0 0.425225225 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Protein export -0.492173913 -0.791501976 -0.668983269 kegg kegg NA NA no no no no no no Lysine degradation Protein export 0.457391304 0 0.595624196 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Protein export 0 0 0.597683398 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Protein export 0 0.687747036 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Protein export 0.756521739 0.72826087 0.762676963 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Protein export 0.700869565 0.774703557 0.536679537 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Protein export -0.509565217 -0.85770751 -0.509137709 kegg kegg NA NA no no no no no no Nitrogen metabolism Protein export -0.648695652 -0.759881423 -0.707335907 kegg kegg NA NA no no no no no no One carbon pool by folate Protein export 0.454782609 0.463438735 0.529472329 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Protein export 0.607826087 0 0.488288288 kegg kegg NA NA no no no no no no Oxidative phosphorylation Protein export 0.507826087 0.769762846 0.442213642 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Protein export -0.416521739 -0.730237154 -0.412870013 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Protein export 0 0.805335968 0.484942085 kegg kegg NA NA no no no no no no Pentose phosphate pathway Protein export -0.806086957 -0.554347826 -0.61029601 kegg kegg NA NA no no no no no no Phenylalanine metabolism Protein export 0 0.481225296 0 kegg kegg NA NA no no no no no no Platinum drug resistance Protein export 0.434782609 0 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Protein export 0 0 -0.432947233 kegg kegg NA NA no no no no no no Propanoate metabolism Protein export 0 0.658102767 0.497554698 kegg kegg NA NA no no no no no no Proteasome Protein export 0.473913043 0.798418972 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Protein export 0 0.501976285 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Protein export 0 0.741106719 0 kegg kegg NA NA no no no no no no Ribosome Protein export 0.680869565 0.759881423 0.529214929 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Protein export 0.744347826 0.442687747 0.652252252 kegg kegg NA NA no no no no no no RNA degradation Protein export 0.786956522 0.820158103 0.768339768 kegg kegg NA NA no no no no no no RNA polymerase Protein export 0.834782609 0.622529644 0.597425997 kegg kegg NA NA no no no no no no RNA transport Protein export 0 0.685770751 0.416216216 kegg kegg NA NA no no no no no no Selenocompound metabolism Protein export 0.510434783 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Protein export -0.451304348 0 0 kegg kegg NA NA no no no no no no Spliceosome Protein export 0.616521739 0 0.65019305 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Protein export -0.643478261 -0.833992095 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Protein export 0.693913043 0.451581028 0.418018018 kegg kegg NA NA no no no no no no Sulfur metabolism Protein export 0 0 -0.546975547 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Protein export 0 0.429841897 0.431660232 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Protein export 0 -0.583003953 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Protein export 0.730434783 0 0.512483912 kegg kegg NA NA no no no no no no Thiamine metabolism Protein export 0 0.599802372 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Protein export 0 0.490118577 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Protein export 0 0.449604743 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Protein export 0 0 0.404375804 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Protein export 0 0.552371542 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Protein export 0.679130435 0.677865613 0.486486486 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Protein processing in endoplasmic reticulum 0 0.77173913 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Protein processing in endoplasmic reticulum -0.490434783 -0.769762846 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Protein processing in endoplasmic reticulum 0 -0.586956522 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Protein processing in endoplasmic reticulum 0 0.614624506 0 kegg kegg NA NA no no no no no no Antifolate resistance Protein processing in endoplasmic reticulum 0 0.450592885 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Protein processing in endoplasmic reticulum -0.516521739 -0.73715415 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Protein processing in endoplasmic reticulum -0.53826087 -0.790513834 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Protein processing in endoplasmic reticulum 0 0.494071146 0 kegg kegg NA NA no no no no no no Autophagy - animal Protein processing in endoplasmic reticulum 0 -0.592885375 0 kegg kegg NA NA no no no no no no Basal transcription factors Protein processing in endoplasmic reticulum 0 0.673913043 0 kegg kegg NA NA no no no no no no Base excision repair Protein processing in endoplasmic reticulum 0.468695652 0.611660079 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Protein processing in endoplasmic reticulum 0 -0.757905138 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Protein processing in endoplasmic reticulum 0.511304348 0.654150198 0 kegg kegg NA NA no no no no no no Butanoate metabolism Protein processing in endoplasmic reticulum 0 0.716403162 0.498069498 kegg kegg NA NA no no no no no no Cell cycle Protein processing in endoplasmic reticulum 0.486956522 0.799407115 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Protein processing in endoplasmic reticulum -0.406086957 -0.875494071 -0.484942085 kegg kegg NA NA no no no no no no Chemokine signaling pathway Protein processing in endoplasmic reticulum -0.529565217 -0.778656126 -0.424195624 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Protein processing in endoplasmic reticulum 0 0.726284585 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Protein processing in endoplasmic reticulum 0 0.659090909 0.506563707 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Protein processing in endoplasmic reticulum 0 -0.497035573 0 kegg kegg NA NA no no no no no no DNA replication Protein processing in endoplasmic reticulum 0.479130435 0.792490119 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Protein processing in endoplasmic reticulum 0 0.743083004 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Protein processing in endoplasmic reticulum 0 0.720355731 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Protein processing in endoplasmic reticulum 0.415652174 0.606719368 0.599485199 kegg kegg NA NA no no no no no no Ether lipid metabolism Protein processing in endoplasmic reticulum 0 0.654150198 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Protein processing in endoplasmic reticulum 0.423478261 0.56027668 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Protein processing in endoplasmic reticulum -0.606086957 -0.860671937 0 kegg kegg NA NA no no no no no no Fatty acid degradation Protein processing in endoplasmic reticulum 0 -0.558300395 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Protein processing in endoplasmic reticulum -0.410434783 -0.602766798 0 kegg kegg NA NA no no no no no no Folate biosynthesis Protein processing in endoplasmic reticulum 0 0.638339921 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Protein processing in endoplasmic reticulum 0 -0.461462451 0 kegg kegg NA NA no no no no no no Galactose metabolism Protein processing in endoplasmic reticulum 0 -0.596837945 0 kegg kegg NA NA no no no no no no Glutathione metabolism Protein processing in endoplasmic reticulum 0.406086957 0.681818182 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Protein processing in endoplasmic reticulum 0.48 0.485177866 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Protein processing in endoplasmic reticulum 0 0.415019763 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Protein processing in endoplasmic reticulum -0.599130435 -0.627470356 -0.512483912 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Protein processing in endoplasmic reticulum 0 0.585968379 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Protein processing in endoplasmic reticulum -0.506956522 -0.462450593 -0.513513514 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Protein processing in endoplasmic reticulum 0 0.679841897 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Protein processing in endoplasmic reticulum -0.500869565 -0.803359684 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Protein processing in endoplasmic reticulum 0 0.537549407 0.4998713 kegg kegg NA NA no no no no no no Lysine degradation Protein processing in endoplasmic reticulum 0 0.489130435 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Protein processing in endoplasmic reticulum 0 0.42687747 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Protein processing in endoplasmic reticulum 0 0.65513834 0 kegg kegg NA NA no no no no no no Mismatch repair Protein processing in endoplasmic reticulum 0 0.60770751 0 kegg kegg NA NA no no no no no no Mitophagy - animal Protein processing in endoplasmic reticulum 0.449565217 0.463438735 0.72020592 kegg kegg NA NA no no no no no no mRNA surveillance pathway Protein processing in endoplasmic reticulum 0 0.84486166 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Protein processing in endoplasmic reticulum 0.597391304 0.890316206 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Protein processing in endoplasmic reticulum 0 -0.656126482 0 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Protein processing in endoplasmic reticulum -0.432173913 -0.623517787 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Protein processing in endoplasmic reticulum -0.626956522 -0.922924901 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Protein processing in endoplasmic reticulum -0.472173913 -0.754940711 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Protein processing in endoplasmic reticulum 0 0 0.479021879 kegg kegg NA NA no no no no no no Nucleotide excision repair Protein processing in endoplasmic reticulum 0.477391304 0.731225296 0.431145431 kegg kegg NA NA no no no no no no One carbon pool by folate Protein processing in endoplasmic reticulum 0.451304348 0.71541502 0 kegg kegg NA NA no no no no no no Oocyte meiosis Protein processing in endoplasmic reticulum 0 0.585968379 0 kegg kegg NA NA no no no no no no Other glycan degradation Protein processing in endoplasmic reticulum 0 0 -0.418790219 kegg kegg NA NA no no no no no no Oxidative phosphorylation Protein processing in endoplasmic reticulum 0 0.598814229 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Protein processing in endoplasmic reticulum -0.568695652 -0.836956522 0 kegg kegg NA NA no no dn no no no Paraprevotella Protein processing in endoplasmic reticulum 0 0.493405267 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Protein processing in endoplasmic reticulum 0 0.85770751 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Protein processing in endoplasmic reticulum -0.497391304 -0.824110672 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Protein processing in endoplasmic reticulum 0 0.563241107 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Protein processing in endoplasmic reticulum -0.411304348 -0.641304348 -0.475160875 kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism Protein processing in endoplasmic reticulum 0.499130435 0.488142292 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Protein processing in endoplasmic reticulum -0.466956522 -0.697628458 0 kegg kegg NA NA no no no no no no Propanoate metabolism Protein processing in endoplasmic reticulum 0 0.58201581 0.542857143 kegg kegg NA NA no no no no no no Proteasome Protein processing in endoplasmic reticulum 0 0.549407115 0 kegg kegg NA NA no no no no no no Protein export Protein processing in endoplasmic reticulum 0.606086957 0.811264822 0.423423423 kegg kegg NA NA no no no no no no Purine metabolism Protein processing in endoplasmic reticulum 0.596521739 0.585968379 0.584298584 kegg kegg NA NA no no no no no no Pyrimidine metabolism Protein processing in endoplasmic reticulum 0 0.682806324 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Protein processing in endoplasmic reticulum 0 0.726284585 0.682368082 kegg kegg NA NA no no no no no no Ras signaling pathway Protein processing in endoplasmic reticulum 0 0.678853755 0 yes kegg kegg NA NA no up up no no no Retinol metabolism Protein processing in endoplasmic reticulum 0 0.434782609 0 kegg kegg NA NA no no no no no no Ribosome Protein processing in endoplasmic reticulum 0 0.583992095 0.63963964 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Protein processing in endoplasmic reticulum 0.506956522 0.72826087 0 kegg kegg NA NA no no no no no no RNA degradation Protein processing in endoplasmic reticulum 0 0.877470356 0 kegg kegg NA NA no no no no no no RNA polymerase Protein processing in endoplasmic reticulum 0.512173913 0.839920949 0.463063063 kegg kegg NA NA no no no no no no RNA transport Protein processing in endoplasmic reticulum 0 0.595849802 0.519176319 kegg kegg NA NA no no no no no no Sphingolipid metabolism Protein processing in endoplasmic reticulum -0.457391304 0 -0.536679537 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Protein processing in endoplasmic reticulum 0 -0.47826087 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Protein processing in endoplasmic reticulum -0.486086957 -0.818181818 -0.45045045 kegg kegg NA NA no no no no no no Steroid biosynthesis Protein processing in endoplasmic reticulum 0.54173913 0.45256917 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Protein processing in endoplasmic reticulum 0 0.414031621 0 kegg kegg NA NA no no no no no no Sulfur metabolism Protein processing in endoplasmic reticulum 0 0.443675889 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Protein processing in endoplasmic reticulum 0 0.611660079 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Protein processing in endoplasmic reticulum 0.409565217 0.527667984 0 kegg kegg NA NA no no no no no no Thiamine metabolism Protein processing in endoplasmic reticulum 0 0.62055336 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Protein processing in endoplasmic reticulum 0 0.419960474 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Protein processing in endoplasmic reticulum 0 0.584980237 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Protein processing in endoplasmic reticulum 0 0.609683794 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Protein processing in endoplasmic reticulum 0.55826087 0.599802372 0.75958816 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Protein processing in endoplasmic reticulum 0 0.699604743 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Protein processing in endoplasmic reticulum 0.556521739 0.804347826 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Protein processing in endoplasmic reticulum 0 -0.517786561 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Proteoglycans in cancer 0 0.528656126 0.492406692 kegg kegg NA NA no no no no no no ABC transporters Proteoglycans in cancer 0 -0.469367589 0 kegg kegg NA NA no up up no no no Adherens junction Proteoglycans in cancer 0 0.591897233 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Proteoglycans in cancer 0 -0.420948617 -0.435521236 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Proteoglycans in cancer 0 0.644268775 0 kegg kegg NA NA no no up no no no African trypanosomiasis Proteoglycans in cancer 0 -0.733201581 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Proteoglycans in cancer 0 -0.748023715 0 kegg kegg NA NA no no no no no no Akkermansia Proteoglycans in cancer 0 0.420779509 0 acetate-producing Genus kegg 0.23 NA no no no no no no "Alanine, aspartate and glutamate metabolism" Proteoglycans in cancer 0 -0.727272727 -0.426512227 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Proteoglycans in cancer 0 0.502964427 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Proteoglycans in cancer 0 -0.833003953 0 kegg kegg NA NA no no no no no no Alzheimer disease Proteoglycans in cancer 0 0.73715415 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Proteoglycans in cancer 0 -0.486166008 0 kegg kegg NA NA no no no no no no Amoebiasis Proteoglycans in cancer -0.471304348 -0.707509881 -0.458944659 kegg kegg NA NA no no no no no no Amphetamine addiction Proteoglycans in cancer 0 0.457509881 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Proteoglycans in cancer 0 0.717391304 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Proteoglycans in cancer 0.716521739 0.899209486 0.815958816 kegg kegg NA NA no no no no no no Apoptosis Proteoglycans in cancer 0 -0.57312253 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Proteoglycans in cancer 0 -0.433794466 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Proteoglycans in cancer 0 0 -0.469498069 kegg kegg NA NA no no no no no no Arginine and proline metabolism Proteoglycans in cancer 0 -0.688735178 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Proteoglycans in cancer 0 -0.678853755 -0.461776062 kegg kegg NA NA no no no no no no Autophagy - animal Proteoglycans in cancer 0 -0.656126482 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Proteoglycans in cancer 0 -0.552371542 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Proteoglycans in cancer 0 0.440711462 0 kegg kegg NA NA no no no no no no Basal transcription factors Proteoglycans in cancer 0 0 0.410553411 kegg kegg NA NA no no no no no no Base excision repair Proteoglycans in cancer 0 0 0.411068211 kegg kegg NA NA no no no no no no Bifidobacterium Proteoglycans in cancer 0 0.511145698 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Bile secretion Proteoglycans in cancer 0 0 -0.432175032 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Proteoglycans in cancer 0 -0.434782609 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Proteoglycans in cancer 0 0 -0.542342342 kegg kegg NA NA no no no no no no Butanoate metabolism Proteoglycans in cancer 0 0.557312253 0.546203346 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Proteoglycans in cancer 0 -0.535573123 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Proteoglycans in cancer 0 0.532608696 0 kegg kegg NA NA no up up no no no Cardiac muscle contraction Proteoglycans in cancer 0 0.739130435 0 kegg kegg NA NA no no up no no no Cell cycle Proteoglycans in cancer 0 0.450592885 0.423423423 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Proteoglycans in cancer 0 -0.559288538 0 kegg kegg NA NA no no no no no no Chagas disease Proteoglycans in cancer 0 -0.604743083 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Proteoglycans in cancer 0 0.57312253 0.521492921 kegg kegg NA NA no no no no no no Collecting duct acid secretion Proteoglycans in cancer -0.474782609 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Proteoglycans in cancer 0 -0.527667984 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Proteoglycans in cancer 0.422608696 0.861660079 0.601029601 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Proteoglycans in cancer 0.42 0.687747036 0.653024453 kegg kegg NA NA no no no no no no DNA replication Proteoglycans in cancer 0 0.551383399 0.501415701 kegg kegg NA NA no no no no no no Dopaminergic synapse Proteoglycans in cancer 0 0.438735178 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Proteoglycans in cancer 0 0.645256917 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Proteoglycans in cancer 0 0.683794466 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Proteoglycans in cancer 0 0.419960474 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Proteoglycans in cancer 0.810434783 0.906126482 0.794594595 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Proteoglycans in cancer 0 0.538537549 0 kegg kegg NA NA no no no no no no Endocrine resistance Proteoglycans in cancer 0 0 -0.443243243 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Proteoglycans in cancer 0 -0.508893281 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Proteoglycans in cancer 0 -0.614624506 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Proteoglycans in cancer 0 -0.72826087 0 kegg kegg NA NA no no no no no no Fatty acid degradation Proteoglycans in cancer 0 -0.608695652 0 kegg kegg NA NA no no no no no no Fatty acid elongation Proteoglycans in cancer 0 0 0.493951094 kegg kegg NA NA no no no no no no Fatty acid metabolism Proteoglycans in cancer 0 -0.611660079 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Proteoglycans in cancer 0 -0.671936759 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Proteoglycans in cancer 0 -0.510869565 0 kegg kegg NA NA no no no no no no Focal adhesion Proteoglycans in cancer 0 0.538537549 0 kegg kegg NA NA no up up no no no Folate biosynthesis Proteoglycans in cancer 0 0.568181818 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Proteoglycans in cancer 0 -0.671936759 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Proteoglycans in cancer 0 -0.588932806 0 kegg kegg NA NA no no no no no no GABAergic synapse Proteoglycans in cancer -0.44 -0.570158103 -0.473873874 kegg kegg NA NA no up up no no no Galactose metabolism Proteoglycans in cancer 0 -0.64229249 0 kegg kegg NA NA no no no no no no Gastric acid secretion Proteoglycans in cancer 0 0.537549407 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Proteoglycans in cancer 0 0.543478261 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Proteoglycans in cancer -0.460869565 -0.508893281 -0.488545689 kegg kegg NA NA no up up no no no Glutathione metabolism Proteoglycans in cancer 0 0.609683794 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Proteoglycans in cancer 0 -0.599802372 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Proteoglycans in cancer 0 -0.575098814 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Proteoglycans in cancer 0 0 -0.565765766 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Proteoglycans in cancer 0 0.673913043 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Proteoglycans in cancer 0 -0.704545455 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Proteoglycans in cancer 0 -0.463438735 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - globo and isoglobo series Proteoglycans in cancer 0 0 -0.419305019 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Proteoglycans in cancer 0 -0.64229249 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Proteoglycans in cancer 0 -0.463438735 -0.521492921 kegg kegg NA NA no no no no no no Hepatitis B Proteoglycans in cancer 0 -0.719367589 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Proteoglycans in cancer 0.733043478 0.907114625 0.795881596 kegg kegg NA NA no no no no no no Hippo signaling pathway Proteoglycans in cancer 0 0.645256917 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Proteoglycans in cancer 0 -0.792490119 0 kegg kegg NA NA no no no no no no Huntington disease Proteoglycans in cancer 0 0.712450593 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Proteoglycans in cancer 0 -0.509881423 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Proteoglycans in cancer 0 0.559288538 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Proteoglycans in cancer 0 -0.425889328 0 kegg kegg NA NA no no no no no no Insulin resistance Proteoglycans in cancer 0 -0.540513834 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Proteoglycans in cancer 0.713043478 0.899209486 0.831660232 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Proteoglycans in cancer 0 0.464426877 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Proteoglycans in cancer 0 -0.738142292 0 kegg kegg NA NA no no no no no no Legionellosis Proteoglycans in cancer 0.489565217 0.712450593 0.447104247 kegg kegg NA NA no no no no no no Leishmaniasis Proteoglycans in cancer 0 0.690711462 0 kegg kegg NA NA no no no no no no Long-term potentiation Proteoglycans in cancer 0 0.529644269 0.482625483 kegg kegg NA NA no no up no no no Lysine degradation Proteoglycans in cancer 0.629565217 0 0 kegg kegg NA NA no no no no no no Lysosome Proteoglycans in cancer -0.447826087 0 0 kegg kegg NA NA no no no no no no Measles Proteoglycans in cancer 0.465217391 0 0 kegg kegg NA NA no no no no no no Melanogenesis Proteoglycans in cancer 0 0.581027668 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Proteoglycans in cancer 0 0.589920949 0 kegg kegg NA NA no no no no no no Mismatch repair Proteoglycans in cancer 0 0 0.448391248 kegg kegg NA NA no no no no no no Mitophagy - animal Proteoglycans in cancer 0 0.501976285 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Proteoglycans in cancer 0 0.627470356 0.446846847 kegg kegg NA NA no no no no no no mTOR signaling pathway Proteoglycans in cancer 0.806956522 0.882411067 0.734620335 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Proteoglycans in cancer 0 0.695652174 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Proteoglycans in cancer 0 -0.416996047 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Proteoglycans in cancer 0 -0.513833992 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Proteoglycans in cancer 0 -0.699604743 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Proteoglycans in cancer 0 -0.757905138 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Proteoglycans in cancer 0 -0.62055336 -0.563963964 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Proteoglycans in cancer 0 -0.635375494 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Proteoglycans in cancer 0 0.626482213 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Proteoglycans in cancer 0 0 0.444015444 kegg kegg NA NA no no no no no no Olfactory transduction Proteoglycans in cancer -0.423478261 -0.538537549 0 kegg kegg NA NA no no no no no no Oocyte meiosis Proteoglycans in cancer 0 0.631422925 0.543371943 kegg kegg NA NA no no no no no no Osteoclast differentiation Proteoglycans in cancer 0 -0.648221344 0 kegg kegg NA NA no no no no no no Other glycan degradation Proteoglycans in cancer 0 -0.458498024 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Proteoglycans in cancer 0 0 -0.416731017 kegg kegg NA NA no up up no no no Oxidative phosphorylation Proteoglycans in cancer 0 0.718379447 0 kegg kegg NA NA no no no no no no Pancreatic secretion Proteoglycans in cancer 0 0.494071146 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Proteoglycans in cancer -0.428695652 -0.820158103 0 kegg kegg NA NA no no dn no no no Parabacteroides Proteoglycans in cancer 0 0 -0.472488578 Genus kegg 4.19E-05 NA no up up no no no "Parathyroid hormone synthesis, secretion and action" Proteoglycans in cancer 0 0.530632411 0 kegg kegg NA NA no no no no no no Parkinson disease Proteoglycans in cancer 0 0.658102767 0 kegg kegg NA NA no no no no no no Pathways in cancer Proteoglycans in cancer 0 -0.488142292 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Proteoglycans in cancer 0 0.658102767 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Proteoglycans in cancer 0 0.602766798 0.584813385 kegg kegg NA NA no no no no no no Pentose phosphate pathway Proteoglycans in cancer 0 -0.450592885 0 kegg kegg NA NA no no no no no no Peroxisome Proteoglycans in cancer 0 -0.678853755 0 kegg kegg NA NA no no no no no no Pertussis Proteoglycans in cancer -0.413043478 -0.554347826 0 kegg kegg NA NA no no dn no no no Phenylalanine metabolism Proteoglycans in cancer 0 0.421936759 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Proteoglycans in cancer -0.412173913 -0.738142292 -0.485714286 kegg kegg NA NA no up up no no no Phototransduction Proteoglycans in cancer 0 0.508893281 0.432175032 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Proteoglycans in cancer 0.673043478 0.530632411 0.800514801 yes kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism Proteoglycans in cancer 0 0 -0.537451737 kegg kegg NA NA no no no no no no PPAR signaling pathway Proteoglycans in cancer 0 -0.43083004 0 kegg kegg NA NA no no no no no no Prion disease Proteoglycans in cancer 0 0.799407115 0.462290862 kegg kegg NA NA no no no no no no Prolactin signaling pathway Proteoglycans in cancer 0 -0.650197628 0 kegg kegg NA NA no no no no no no Propanoate metabolism Proteoglycans in cancer 0 0.677865613 0.661003861 kegg kegg NA NA no no no no no no Proteasome Proteoglycans in cancer 0 0.598814229 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Proteoglycans in cancer 0 -0.602766798 0 yes kegg kegg NA NA no up up no no no Protein export Proteoglycans in cancer 0 0.804347826 0.661003861 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Proteoglycans in cancer 0 0.666996047 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Proteoglycans in cancer 0 0.62055336 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Proteoglycans in cancer 0 0.717391304 0.407722008 kegg kegg NA NA no no no no no no Ras signaling pathway Proteoglycans in cancer 0 0.62944664 0 yes kegg kegg NA NA no up up no no no Renin secretion Proteoglycans in cancer 0 0.529644269 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Proteoglycans in cancer -0.439130435 -0.443675889 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Proteoglycans in cancer 0 0.738142292 0.481595882 kegg kegg NA NA no no up no no no Ribosome Proteoglycans in cancer 0.417391304 0.863636364 0.603088803 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Proteoglycans in cancer 0.439130435 0 0.49034749 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Proteoglycans in cancer 0 -0.623517787 0 kegg kegg NA NA no no no no no no RNA degradation Proteoglycans in cancer 0 0.75 0.593564994 kegg kegg NA NA no no no no no no RNA polymerase Proteoglycans in cancer 0 0.514822134 0.501930502 kegg kegg NA NA no no no no no no RNA transport Proteoglycans in cancer 0.64 0.878458498 0.700643501 kegg kegg NA NA no no no no no no Roseburia Proteoglycans in cancer -0.449565217 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Salivary secretion Proteoglycans in cancer -0.448695652 0 0 kegg kegg NA NA no no no no no no Serotonergic synapse Proteoglycans in cancer 0 0 -0.525096525 kegg kegg NA NA no no no no no no Shigellosis Proteoglycans in cancer 0 0.56027668 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Proteoglycans in cancer 0 -0.60770751 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Proteoglycans in cancer 0 0.509881423 0.593307593 kegg kegg NA NA no no no no no no Spliceosome Proteoglycans in cancer 0.494782609 0 0.503217503 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Proteoglycans in cancer 0 -0.808300395 0 kegg kegg NA NA no no no no no no Sulfur metabolism Proteoglycans in cancer 0 0 -0.45971686 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Proteoglycans in cancer 0 -0.500988142 0 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Proteoglycans in cancer 0.534782609 0 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Proteoglycans in cancer 0 -0.490118577 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Proteoglycans in cancer 0 0.726284585 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Proteoglycans in cancer 0 0 0.404118404 kegg kegg NA NA no no no no no no Thermogenesis Proteoglycans in cancer 0 0.785573123 0.522522523 kegg kegg NA NA no no no no no no Thiamine metabolism Proteoglycans in cancer 0.611304348 0.574110672 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Proteoglycans in cancer 0 0.551383399 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Proteoglycans in cancer 0 0 -0.418532819 kegg kegg NA NA no no no no no no Tight junction Proteoglycans in cancer 0 0.471343874 0 kegg kegg NA NA no no no no no no TNF signaling pathway Proteoglycans in cancer 0 -0.496047431 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Proteoglycans in cancer 0 -0.591897233 0 yes kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Proteoglycans in cancer 0 -0.754940711 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Proteoglycans in cancer 0 0 0.49009009 kegg kegg NA NA no up no no no no Tuberculosis Proteoglycans in cancer -0.487826087 0 0 kegg kegg NA NA no no dn no no no Type II diabetes mellitus Proteoglycans in cancer 0 -0.518774704 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Proteoglycans in cancer 0 0.529644269 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Proteoglycans in cancer 0 0 0.548005148 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Proteoglycans in cancer 0 0.600790514 0.438610039 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Proteoglycans in cancer 0 0.524703557 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Proteoglycans in cancer 0 0.494071146 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Proteoglycans in cancer 0 -0.449604743 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Proteoglycans in cancer 0 0.708498024 0.44015444 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Proximal tubule bicarbonate reclamation 0 0.683794466 0 kegg kegg NA NA no no no no no no Adherens junction Proximal tubule bicarbonate reclamation 0 0.463438735 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Proximal tubule bicarbonate reclamation -0.50173913 -0.673913043 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Proximal tubule bicarbonate reclamation 0 0.479249012 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Proximal tubule bicarbonate reclamation 0 -0.694664032 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Proximal tubule bicarbonate reclamation 0 -0.734189723 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Proximal tubule bicarbonate reclamation 0 0.515810277 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Proximal tubule bicarbonate reclamation 0 -0.434782609 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Proximal tubule bicarbonate reclamation 0 0.566205534 0 kegg kegg NA NA no no no no no no Antifolate resistance Proximal tubule bicarbonate reclamation 0 0.489130435 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Proximal tubule bicarbonate reclamation 0 0.64229249 0 kegg kegg NA NA no no no no no no Apoptosis Proximal tubule bicarbonate reclamation -0.515652174 -0.766798419 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Proximal tubule bicarbonate reclamation 0 -0.644268775 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Proximal tubule bicarbonate reclamation -0.412173913 -0.756916996 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Proximal tubule bicarbonate reclamation 0 0.580039526 0 kegg kegg NA NA no no no no no no Autophagy - animal Proximal tubule bicarbonate reclamation 0 -0.708498024 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Proximal tubule bicarbonate reclamation -0.59826087 -0.744071146 -0.454568855 kegg kegg NA NA no no no no no no Basal transcription factors Proximal tubule bicarbonate reclamation 0.502608696 0.58201581 0.57039897 kegg kegg NA NA no no no no no no Base excision repair Proximal tubule bicarbonate reclamation 0.435652174 0.601778656 0.537966538 kegg kegg NA NA no no no no no no beta-Alanine metabolism Proximal tubule bicarbonate reclamation 0 0.446640316 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Proximal tubule bicarbonate reclamation 0 -0.64229249 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Proximal tubule bicarbonate reclamation 0 0.561264822 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Proximal tubule bicarbonate reclamation 0.547826087 0.420948617 0.513513514 kegg kegg NA NA no no no no no no Butanoate metabolism Proximal tubule bicarbonate reclamation 0 0.769762846 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Proximal tubule bicarbonate reclamation -0.443478261 -0.820158103 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Proximal tubule bicarbonate reclamation 0 -0.651185771 0 yes kegg kegg NA NA no up up no no no Cardiac muscle contraction Proximal tubule bicarbonate reclamation 0 0.466403162 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Proximal tubule bicarbonate reclamation 0 -0.436758893 0 kegg kegg NA NA no no no no no no Cell cycle Proximal tubule bicarbonate reclamation 0.605217391 0.751976285 0.581724582 kegg kegg NA NA no no no no no no Cellular senescence Proximal tubule bicarbonate reclamation 0 -0.603754941 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Proximal tubule bicarbonate reclamation 0 -0.66798419 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Proximal tubule bicarbonate reclamation 0 -0.579051383 0 kegg kegg NA NA no no no no no no Circadian entrainment Proximal tubule bicarbonate reclamation 0.450434783 0.476284585 0 kegg kegg NA NA no up up no no no Circadian rhythm Proximal tubule bicarbonate reclamation 0 0.435770751 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Proximal tubule bicarbonate reclamation 0.517391304 0.806324111 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Proximal tubule bicarbonate reclamation 0 -0.570158103 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Proximal tubule bicarbonate reclamation 0.742608696 0.757905138 0.463320463 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Proximal tubule bicarbonate reclamation 0 -0.508893281 0 kegg kegg NA NA no no no no no no DNA replication Proximal tubule bicarbonate reclamation 0.648695652 0.850790514 0.449420849 kegg kegg NA NA no no no no no no Dopaminergic synapse Proximal tubule bicarbonate reclamation 0 0.513833992 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Proximal tubule bicarbonate reclamation 0.515652174 0.865612648 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Proximal tubule bicarbonate reclamation 0 0.779644269 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Proximal tubule bicarbonate reclamation 0.593043478 0.619565217 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Proximal tubule bicarbonate reclamation 0 0.515810277 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Proximal tubule bicarbonate reclamation 0 0.489130435 0 kegg kegg NA NA no no no no no no Endocytosis Proximal tubule bicarbonate reclamation 0 -0.471343874 -0.464864865 kegg kegg NA NA no no no no no no Estrogen signaling pathway Proximal tubule bicarbonate reclamation 0.74 0.711462451 0.422136422 kegg kegg NA NA no no no no no no Ether lipid metabolism Proximal tubule bicarbonate reclamation 0 0.496047431 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Proximal tubule bicarbonate reclamation 0.567826087 0.471343874 0.59021879 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Proximal tubule bicarbonate reclamation 0 -0.750988142 0 kegg kegg NA NA no no no no no no Fatty acid degradation Proximal tubule bicarbonate reclamation 0 -0.483201581 0 kegg kegg NA NA no no no no no no Fatty acid elongation Proximal tubule bicarbonate reclamation 0 0.433794466 0.401801802 kegg kegg NA NA no no no no no no Fatty acid metabolism Proximal tubule bicarbonate reclamation 0 -0.423913043 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Proximal tubule bicarbonate reclamation -0.56173913 -0.816205534 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Proximal tubule bicarbonate reclamation 0 -0.578063241 0 kegg kegg NA NA no no no no no no Focal adhesion Proximal tubule bicarbonate reclamation 0 0.517786561 0 kegg kegg NA NA no up up no no no Folate biosynthesis Proximal tubule bicarbonate reclamation 0 0.571146245 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Proximal tubule bicarbonate reclamation 0 -0.415019763 0.483655084 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Proximal tubule bicarbonate reclamation 0 -0.431818182 0 kegg kegg NA NA no no no no no no GABAergic synapse Proximal tubule bicarbonate reclamation 0 -0.483201581 0 kegg kegg NA NA no up up no no no Galactose metabolism Proximal tubule bicarbonate reclamation 0 -0.414031621 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Proximal tubule bicarbonate reclamation 0.517391304 0.652173913 0 kegg kegg NA NA no no no no no no Glutathione metabolism Proximal tubule bicarbonate reclamation 0 0.576086957 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Proximal tubule bicarbonate reclamation -0.537391304 0 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Proximal tubule bicarbonate reclamation 0 0.523715415 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Proximal tubule bicarbonate reclamation -0.685217391 -0.732213439 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Proximal tubule bicarbonate reclamation 0 0.613636364 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Proximal tubule bicarbonate reclamation -0.552173913 0 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Proximal tubule bicarbonate reclamation 0 0.535573123 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Proximal tubule bicarbonate reclamation -0.559130435 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Proximal tubule bicarbonate reclamation 0 -0.754940711 0 kegg kegg NA NA no no no no no no GnRH secretion Proximal tubule bicarbonate reclamation 0 -0.433794466 0 kegg kegg NA NA no up up no no no Hedgehog signaling pathway Proximal tubule bicarbonate reclamation 0 0.502964427 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Proximal tubule bicarbonate reclamation 0 0.477272727 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Proximal tubule bicarbonate reclamation 0 0.482213439 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Proximal tubule bicarbonate reclamation 0 0.585968379 0 kegg kegg NA NA no no no no no no Homologous recombination Proximal tubule bicarbonate reclamation 0.486086957 0 0.671814672 kegg kegg NA NA no no no no no no IL-17 signaling pathway Proximal tubule bicarbonate reclamation -0.509565217 -0.742094862 -0.42985843 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Proximal tubule bicarbonate reclamation 0 0.557312253 0 kegg kegg NA NA no no no no no no Insulin resistance Proximal tubule bicarbonate reclamation 0 -0.65513834 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Proximal tubule bicarbonate reclamation 0 0.62055336 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Proximal tubule bicarbonate reclamation 0 -0.557312253 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Proximal tubule bicarbonate reclamation 0 0.441699605 0 kegg kegg NA NA no no no no no no Long-term potentiation Proximal tubule bicarbonate reclamation 0 0.659090909 0.470785071 kegg kegg NA NA no no up no no no Longevity regulating pathway - multiple species Proximal tubule bicarbonate reclamation 0.507826087 0 0 kegg kegg NA NA no no no no no no Lysosome Proximal tubule bicarbonate reclamation -0.668695652 -0.502964427 -0.444530245 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Proximal tubule bicarbonate reclamation -0.408695652 0 0 kegg kegg NA NA no no no no no no Melanogenesis Proximal tubule bicarbonate reclamation 0 0.556324111 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Proximal tubule bicarbonate reclamation 0.472173913 0.83201581 0 kegg kegg NA NA no no no no no no Mismatch repair Proximal tubule bicarbonate reclamation 0.674782609 0.812252964 0.592792793 kegg kegg NA NA no no no no no no mRNA surveillance pathway Proximal tubule bicarbonate reclamation 0 0.590909091 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Proximal tubule bicarbonate reclamation 0 0.490118577 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Proximal tubule bicarbonate reclamation 0.485217391 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Proximal tubule bicarbonate reclamation 0.444347826 0.843873518 0.422651223 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Proximal tubule bicarbonate reclamation 0 -0.559288538 -0.425225225 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Proximal tubule bicarbonate reclamation 0 -0.429841897 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Proximal tubule bicarbonate reclamation 0 -0.636363636 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Proximal tubule bicarbonate reclamation -0.493913043 -0.588932806 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Proximal tubule bicarbonate reclamation -0.406086957 -0.731225296 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Proximal tubule bicarbonate reclamation 0 -0.777667984 -0.41003861 kegg kegg NA NA no no no no no no Nitrogen metabolism Proximal tubule bicarbonate reclamation -0.442608696 -0.701581028 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Proximal tubule bicarbonate reclamation 0 -0.773715415 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Proximal tubule bicarbonate reclamation 0.424347826 0.57312253 0 kegg kegg NA NA no no no no no no Notch signaling pathway Proximal tubule bicarbonate reclamation -0.428695652 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Proximal tubule bicarbonate reclamation 0.702608696 0.82312253 0.613642214 kegg kegg NA NA no no no no no no Olfactory transduction Proximal tubule bicarbonate reclamation 0 -0.492094862 0 kegg kegg NA NA no no no no no no One carbon pool by folate Proximal tubule bicarbonate reclamation 0.604347826 0.793478261 0 kegg kegg NA NA no no no no no no Oocyte meiosis Proximal tubule bicarbonate reclamation 0.63826087 0.73715415 0.693178893 kegg kegg NA NA no no no no no no Osteoclast differentiation Proximal tubule bicarbonate reclamation -0.584347826 -0.803359684 -0.424710425 kegg kegg NA NA no no no no no no Oxidative phosphorylation Proximal tubule bicarbonate reclamation 0 0.4743083 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Proximal tubule bicarbonate reclamation 0 -0.603754941 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Proximal tubule bicarbonate reclamation 0.626086957 0.837944664 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Proximal tubule bicarbonate reclamation -0.626956522 -0.616600791 -0.440669241 kegg kegg NA NA no no no no no no Peroxisome Proximal tubule bicarbonate reclamation 0 -0.601778656 0 kegg kegg NA NA no no no no no no Phagosome Proximal tubule bicarbonate reclamation -0.409565217 -0.499011858 -0.475675676 kegg kegg NA NA no no no no no no Phenylalanine metabolism Proximal tubule bicarbonate reclamation 0 0.730237154 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Proximal tubule bicarbonate reclamation 0 0 0.405662806 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Proximal tubule bicarbonate reclamation -0.50173913 -0.704545455 -0.423423423 kegg kegg NA NA no up up no no no Phototransduction Proximal tubule bicarbonate reclamation 0.451304348 0.53458498 0.587644788 kegg kegg NA NA no no no no no no Platinum drug resistance Proximal tubule bicarbonate reclamation 0 0 0.584813385 kegg kegg NA NA no no no no no no PPAR signaling pathway Proximal tubule bicarbonate reclamation 0 -0.78458498 -0.407207207 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Proximal tubule bicarbonate reclamation 0.564347826 0.500988142 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Proximal tubule bicarbonate reclamation 0 0 0.403346203 kegg kegg NA NA no no no no no no Prolactin signaling pathway Proximal tubule bicarbonate reclamation 0 -0.820158103 0 kegg kegg NA NA no no no no no no Propanoate metabolism Proximal tubule bicarbonate reclamation 0.585217391 0.690711462 0 kegg kegg NA NA no no no no no no Proteasome Proximal tubule bicarbonate reclamation 0 0.585968379 0 kegg kegg NA NA no no no no no no Protein export Proximal tubule bicarbonate reclamation 0.536521739 0.723320158 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Proximal tubule bicarbonate reclamation 0.530434783 0.765810277 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Proximal tubule bicarbonate reclamation 0 0.773715415 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Proximal tubule bicarbonate reclamation 0.640869565 0.750988142 0 kegg kegg NA NA no no no no no no Ras signaling pathway Proximal tubule bicarbonate reclamation 0 0.802371542 0.438095238 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Proximal tubule bicarbonate reclamation 0 0.488142292 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Proximal tubule bicarbonate reclamation 0 -0.649209486 0 kegg kegg NA NA no no no no no no Renin secretion Proximal tubule bicarbonate reclamation 0.48 0.597826087 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Proximal tubule bicarbonate reclamation 0 -0.546442688 0 kegg kegg NA NA no no no no no no Retinol metabolism Proximal tubule bicarbonate reclamation 0.487826087 0.66798419 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Proximal tubule bicarbonate reclamation 0 0.580039526 0 kegg kegg NA NA no no up no no no Ribosome Proximal tubule bicarbonate reclamation 0 0.499011858 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Proximal tubule bicarbonate reclamation 0.454782609 0.657114625 0.523809524 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Proximal tubule bicarbonate reclamation 0 -0.731225296 0 kegg kegg NA NA no no no no no no RNA degradation Proximal tubule bicarbonate reclamation 0 0.76284585 0 kegg kegg NA NA no no no no no no RNA polymerase Proximal tubule bicarbonate reclamation 0.468695652 0.719367589 0 kegg kegg NA NA no no no no no no RNA transport Proximal tubule bicarbonate reclamation 0.414782609 0.467391304 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Proximal tubule bicarbonate reclamation -0.646956522 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Proximal tubule bicarbonate reclamation 0 -0.477272727 0 kegg kegg NA NA no no no no no no Spliceosome Proximal tubule bicarbonate reclamation 0 0 0.518146718 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Proximal tubule bicarbonate reclamation 0 -0.623517787 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Proximal tubule bicarbonate reclamation 0.593043478 0.67687747 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Proximal tubule bicarbonate reclamation 0 0.644268775 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Proximal tubule bicarbonate reclamation -0.415652174 -0.548418972 -0.458944659 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Proximal tubule bicarbonate reclamation 0.594782609 0.694664032 0.529472329 kegg kegg NA NA no no no no no no Taste transduction Proximal tubule bicarbonate reclamation 0.543478261 0.656126482 0 kegg kegg NA NA no no up no no no Terpenoid backbone biosynthesis Proximal tubule bicarbonate reclamation 0.660869565 0.484189723 0.424453024 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Proximal tubule bicarbonate reclamation 0 0.709486166 0.526640927 kegg kegg NA NA no no no no no no Thermogenesis Proximal tubule bicarbonate reclamation 0 0.545454545 0 kegg kegg NA NA no no no no no no Thiamine metabolism Proximal tubule bicarbonate reclamation 0 0.575098814 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Proximal tubule bicarbonate reclamation 0 0.42687747 0 kegg kegg NA NA no no no no no no TNF signaling pathway Proximal tubule bicarbonate reclamation 0 -0.744071146 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Proximal tubule bicarbonate reclamation 0 -0.866600791 -0.495238095 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Proximal tubule bicarbonate reclamation 0 0.613636364 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Proximal tubule bicarbonate reclamation 0 -0.498023715 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Proximal tubule bicarbonate reclamation 0.576521739 0.750988142 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Proximal tubule bicarbonate reclamation 0 0.750988142 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Proximal tubule bicarbonate reclamation 0.44 0.769762846 0.463577864 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Proximal tubule bicarbonate reclamation 0 0.748023715 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Proximal tubule bicarbonate reclamation 0 0.481225296 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Proximal tubule bicarbonate reclamation 0 0.519762846 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Proximal tubule bicarbonate reclamation 0 -0.4743083 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Proximal tubule bicarbonate reclamation 0 0.767786561 0 kegg kegg NA NA no no no no no no "12,13-EPOME+blood" PUFA/MUFA+blood 0 0 -0.40857856 serum_ARA serum_fattyacid 0.901 0.00108 no no no dn no up 16:0/14:0-PC+blood PUFA/MUFA+blood 0 0 0.414017094 serum_phospholipids serum_fattyacid 0.0206 0.00108 no up up dn no up 16:0/16:1-PI+blood PUFA/MUFA+blood 0 -0.507352941 0 serum_phospholipids serum_fattyacid 0.262 0.00108 no no no dn no up 16:0/18:0-PC+blood PUFA/MUFA+blood 0 0 0.51042735 serum_phospholipids serum_fattyacid 0.521 0.00108 no no no dn no up 16:0/18:0-PS+blood PUFA/MUFA+blood 0 -0.492647059 0 serum_phospholipids serum_fattyacid 0.377 0.00108 no no no dn no up 16:0/18:1-PE+blood PUFA/MUFA+blood 0 0 -0.60957265 serum_phospholipids serum_fattyacid 0.000107 0.00108 up up no dn no up 16:0/18:2-PC+blood PUFA/MUFA+blood 0 0.485294118 0 serum_phospholipids serum_fattyacid 3.24E-06 0.00108 no up up dn no up 16:0/20:4-PE+blood PUFA/MUFA+blood 0 0 -0.72034188 serum_phospholipids serum_fattyacid 0.00139 0.00108 up up no dn no up 16:0/20:4-PI+blood PUFA/MUFA+blood 0 -0.553921569 0 serum_phospholipids serum_fattyacid 0.558 0.00108 no no no dn no up 16:0/22:0-PE+blood PUFA/MUFA+blood 0 0 0.496068376 serum_phospholipids serum_fattyacid 0.00839 0.00108 dn no up dn no up 16:0/22:6-PE+blood PUFA/MUFA+blood 0 0 -0.598632479 serum_phospholipids serum_fattyacid 0.000934 0.00108 up up no dn no up 16:0+blood PUFA/MUFA+blood -0.535338346 0 0 yes serum_fattyacid serum_fattyacid 0.00876 0.00108 up no no dn no up 16:1+blood PUFA/MUFA+blood -0.49924812 -0.50245098 -0.532991453 yes serum_fattyacid serum_fattyacid 0.0186 0.00108 no no dn dn no up 18:0-LPE+blood PUFA/MUFA+blood -0.50075188 0 0 serum_phospholipids serum_fattyacid 0.491 0.00108 no no no dn no up 18:0/18:0-PS+blood PUFA/MUFA+blood 0 -0.524509804 0 serum_phospholipids serum_fattyacid 0.00617 0.00108 no up no dn no up 18:0/18:1-PE+blood PUFA/MUFA+blood 0 0 -0.446837607 serum_phospholipids serum_fattyacid 0.00716 0.00108 up up no dn no up 18:0/18:1-PG+blood PUFA/MUFA+blood 0 -0.487745098 -0.441367521 serum_phospholipids serum_fattyacid 0.000842 0.00108 no up no dn no up 18:0/18:1-PI+blood PUFA/MUFA+blood 0 -0.534313725 0 serum_phospholipids serum_fattyacid 0.599 0.00108 no no no dn no up 18:0/18:2-PC+blood PUFA/MUFA+blood 0 0 0.433162393 serum_phospholipids serum_fattyacid 1.74E-06 0.00108 no up up dn no up 18:0/20:3-PI+blood PUFA/MUFA+blood -0.527819549 0 0 serum_phospholipids serum_fattyacid 0.377 0.00108 no no no dn no up 18:0/22:6-PA+blood PUFA/MUFA+blood 0 0 0.45982906 serum_phospholipids serum_fattyacid 0.22 0.00108 no no no dn no up 18:0+blood PUFA/MUFA+blood -0.469172932 0 0 serum_fattyacid serum_fattyacid 0.344 0.00108 no no no dn no up 18:1-LPE+blood PUFA/MUFA+blood -0.494736842 0 0 serum_phospholipids serum_fattyacid 0.117 0.00108 no no no dn no up 18:1/16:0-PC+blood PUFA/MUFA+blood 0.445112782 0.485294118 0 serum_phospholipids serum_fattyacid 2.43E-05 0.00108 no up up dn no up 18:1/16:0-PE+blood PUFA/MUFA+blood 0 0 -0.601367521 serum_phospholipids serum_fattyacid 0.000182 0.00108 up up no dn no up 18:1/16:1-PE+blood PUFA/MUFA+blood 0 0 -0.684786325 serum_phospholipids serum_fattyacid 0.000184 0.00108 up up no dn no up 18:1/18:0-PC+blood PUFA/MUFA+blood 0 0 0.446837607 serum_phospholipids serum_fattyacid 1.83E-06 0.00108 no up up dn no up 18:1/18:0-PE+blood PUFA/MUFA+blood 0 0 -0.712820513 serum_phospholipids serum_fattyacid 1.39E-06 0.00108 up up no dn no up 18:1/18:0-PI+blood PUFA/MUFA+blood -0.514285714 0 0 serum_phospholipids serum_fattyacid 0.0931 0.00108 no no up dn no up 18:1/18:1-PE+blood PUFA/MUFA+blood 0 0 -0.723760684 serum_phospholipids serum_fattyacid 1.03E-05 0.00108 up up no dn no up 18:1/18:1-PI+blood PUFA/MUFA+blood 0 -0.632352941 0 serum_phospholipids serum_fattyacid 0.111 0.00108 dn no no dn no up 18:1/18:2-PE+blood PUFA/MUFA+blood 0 0 -0.630769231 serum_phospholipids serum_fattyacid 0.000293 0.00108 up up no dn no up 18:1/18:2-PG+blood PUFA/MUFA+blood 0 0 0.417435897 serum_phospholipids serum_fattyacid 5.58E-07 0.00108 no up up dn no up 18:1/20:4-PE+blood PUFA/MUFA+blood 0 -0.492647059 -0.60957265 serum_phospholipids serum_fattyacid 0.0578 0.00108 up no no dn no up 18:1+blood PUFA/MUFA+blood -0.742857143 0 -0.586324786 yes serum_fattyacid serum_fattyacid 0.00202 0.00108 up no dn dn no up 18:2-LPA+blood PUFA/MUFA+blood 0 0.490196078 0 serum_phospholipids serum_fattyacid 0.00684 0.00108 dn no up dn no up 18:2-LPE+blood PUFA/MUFA+blood 0 0.509803922 0 serum_phospholipids serum_fattyacid 0.112 0.00108 no no no dn no up 18:2/16:0-PC+blood PUFA/MUFA+blood 0 0.620098039 0.458461538 serum_phospholipids serum_fattyacid 8.67E-05 0.00108 no up up dn no up 20:0-LPC+blood PUFA/MUFA+blood -0.556390977 0 0 serum_phospholipids serum_fattyacid 0.199 0.00108 no no no dn no up 20:1-LPA+blood PUFA/MUFA+blood 0.503759398 0 0 serum_phospholipids serum_fattyacid 0.0187 0.00108 dn dn no dn no up 20:1-LPC+blood PUFA/MUFA+blood 0 0 0.468034188 serum_phospholipids serum_fattyacid 0.217 0.00108 no no no dn no up 20:1/20:4-PE+blood PUFA/MUFA+blood 0 -0.541666667 -0.434529915 serum_phospholipids serum_fattyacid 0.0042 0.00108 up up no dn no up 20:2-LPC+blood PUFA/MUFA+blood 0 0 0.571965812 serum_phospholipids serum_fattyacid 0.119 0.00108 no no up dn no up 20:2/18:1-PE+blood PUFA/MUFA+blood 0 0 -0.437264957 serum_phospholipids serum_fattyacid 0.00208 0.00108 up up no dn no up 20:2/18:3-PE+blood PUFA/MUFA+blood 0 0 -0.426324786 serum_phospholipids serum_fattyacid 0.0391 0.00108 up up no dn no up 20:2+blood PUFA/MUFA+blood 0 0.519607843 0 serum_fattyacid serum_fattyacid 0.478 0.00108 no no no dn no up 20:3-LPE+blood PUFA/MUFA+blood -0.572932331 0 0 serum_phospholipids serum_fattyacid 0.084 0.00108 no up no dn no up 20:3/18:0-PC+blood PUFA/MUFA+blood 0 0 0.442735043 serum_phospholipids serum_fattyacid 0.296 0.00108 no no no dn no up 20:4-LPA+blood PUFA/MUFA+blood 0 0.492647059 0 serum_phospholipids serum_fattyacid 0.398 0.00108 no no no dn no up 20:4/18:0-PE+blood PUFA/MUFA+blood 0 0 -0.647179487 serum_phospholipids serum_fattyacid 0.000755 0.00108 up up no dn no up 22:2-LPA+blood PUFA/MUFA+blood 0.520300752 0 0 serum_phospholipids serum_fattyacid 0.0443 0.00108 dn no no dn no up AGE-RAGE signaling pathway in diabetic complications PUFA/MUFA+blood 0 0 -0.403076923 kegg serum_fattyacid NA 0.00108 no no no dn no up B cell receptor signaling pathway PUFA/MUFA+blood 0 0.526470588 0 kegg serum_fattyacid NA 0.00108 no no no dn no up C-type lectin receptor signaling pathway PUFA/MUFA+blood 0 0.532352941 -0.414615385 kegg serum_fattyacid NA 0.00108 no no no dn no up Cell adhesion molecules PUFA/MUFA+blood 0 0 -0.438461538 kegg serum_fattyacid NA 0.00108 no no no dn no up Cell cycle PUFA/MUFA+blood 0 -0.623529412 0 kegg serum_fattyacid NA 0.00108 no no no dn no up cGMP-PKG signaling pathway PUFA/MUFA+blood 0 0 -0.44 kegg serum_fattyacid NA 0.00108 no no no dn no up Chagas disease PUFA/MUFA+blood 0 0.585294118 0 kegg serum_fattyacid NA 0.00108 no no no dn no up Choline+blood PUFA/MUFA+blood 0 0.637254902 0 serum_choline serum_fattyacid 0.0395 0.00108 no up no dn no up Clostridium PUFA/MUFA+blood 0 -0.513014322 0.446314805 Genus serum_fattyacid 0.925 0.00108 no no no dn no up Cytosolic DNA-sensing pathway PUFA/MUFA+blood 0.570175439 0 0 kegg serum_fattyacid NA 0.00108 no no no dn no up d18:0-24:1-SM+blood PUFA/MUFA+blood -0.484210526 0 0 serum_phospholipids serum_fattyacid 0.0609 0.00108 no dn dn dn no up d18:1-14:1-SM+blood PUFA/MUFA+blood 0 -0.526960784 0 serum_phospholipids serum_fattyacid 0.0952 0.00108 no dn no dn no up DHA+blood PUFA/MUFA+blood 0 0.539215686 0 serum_ARA serum_fattyacid 0.872 0.00108 no no no dn no up DPA+blood PUFA/MUFA+blood 0 0.485294118 0 serum_ARA serum_fattyacid 0.519 0.00108 no no no dn no up Epithelial cell signaling in Helicobacter pylori infection PUFA/MUFA+blood 0 0.605882353 -0.499230769 kegg serum_fattyacid NA 0.00108 no no no dn no up Estrogen signaling pathway PUFA/MUFA+blood 0 -0.614705882 0 kegg serum_fattyacid NA 0.00108 no no no dn no up Ethanolamine+blood PUFA/MUFA+blood 0 0.799019608 0 serum_aminoacids serum_fattyacid 0.122 0.00108 up no no dn no up GDCA+blood PUFA/MUFA+blood 0 0.531862745 0 serum_bileacids serum_fattyacid 0.632 0.00108 no no no dn no up GLCA+blood PUFA/MUFA+blood 0 0 -0.41825818 serum_bileacids serum_fattyacid 0.319 0.00108 no no no dn no up Glycine+blood PUFA/MUFA+blood 0 0.522058824 0.417435897 serum_aminoacids serum_fattyacid 0.00408 0.00108 dn no up dn no up HDCA+blood PUFA/MUFA+blood 0.457488141 0 0 serum_bileacids serum_fattyacid 0.483 0.00108 no no no dn no up Hypotaurine+blood PUFA/MUFA+blood 0 0.5 0 serum_aminoacids serum_fattyacid 0.933 0.00108 no no no dn no up L-Arginine+blood PUFA/MUFA+blood 0 0 0.402393162 serum_aminoacids serum_fattyacid 0.316 0.00108 no no no dn no up L-Asparagine+blood PUFA/MUFA+blood 0 0 0.466666667 serum_aminoacids serum_fattyacid 0.784 0.00108 no no no dn no up L-Aspartic acid+blood PUFA/MUFA+blood 0.496240602 0 0 yes serum_aminoacids serum_fattyacid 0.0226 0.00108 up up no dn no up L-Glutamic acid+blood PUFA/MUFA+blood 0 0.504901961 0 yes serum_aminoacids serum_fattyacid 6.20E-05 0.00108 up up no dn no up L-Phenylalanine+stool PUFA/MUFA+blood 0 0 0.458646617 stool_cometabolism serum_fattyacid 0.398 0.00108 no no no dn no up L-Tyrosine+stool PUFA/MUFA+blood 0 0 0.566917293 stool_cometabolism serum_fattyacid 0.44 0.00108 no no no dn no up Lipid and atherosclerosis PUFA/MUFA+blood 0 0 -0.481538462 kegg serum_fattyacid NA 0.00108 no no no dn no up Long-term potentiation PUFA/MUFA+blood 0 -0.55 0 kegg serum_fattyacid NA 0.00108 no no up dn no up mRNA surveillance pathway PUFA/MUFA+blood 0 -0.576470588 0 kegg serum_fattyacid NA 0.00108 no no no dn no up MUFA+blood PUFA/MUFA+blood -0.706766917 0 -0.599316239 serum_fattyacid serum_fattyacid 0.00175 0.00108 up no dn dn no up n6/n3+blood PUFA/MUFA+blood 0 0.492647059 0 serum_fattyacid serum_fattyacid 0.226 0.00108 no no no dn no up NOD-like receptor signaling pathway PUFA/MUFA+blood 0 0.505882353 -0.473076923 kegg serum_fattyacid NA 0.00108 no no no dn no up Odoribacter PUFA/MUFA+blood -0.454434217 0 0 butyrate-producing Genus serum_fattyacid 0.798 0.00108 no no no dn no up Oocyte meiosis PUFA/MUFA+blood 0 -0.635294118 0 kegg serum_fattyacid NA 0.00108 no no no dn no up Osteoclast differentiation PUFA/MUFA+blood 0 0 -0.519230769 kegg serum_fattyacid NA 0.00108 no no no dn no up PD-L1 expression and PD-1 checkpoint pathway in cancer PUFA/MUFA+blood 0 0.585294118 0 kegg serum_fattyacid NA 0.00108 no no no dn no up Pertussis PUFA/MUFA+blood 0 0 -0.438461538 kegg serum_fattyacid NA 0.00108 no no dn dn no up PPAR signaling pathway PUFA/MUFA+blood 0 0.544117647 -0.581538462 kegg serum_fattyacid NA 0.00108 no no no dn no up Protein processing in endoplasmic reticulum PUFA/MUFA+blood 0 -0.579411765 0 kegg serum_fattyacid NA 0.00108 no no no dn no up Proteoglycans in cancer PUFA/MUFA+blood 0.484210526 0 0 kegg serum_fattyacid NA 0.00108 no no no dn no up Ras signaling pathway PUFA/MUFA+blood 0 -0.717647059 0 yes kegg serum_fattyacid NA 0.00108 no up up dn no up Regulation of actin cytoskeleton PUFA/MUFA+blood 0 -0.517647059 0 kegg serum_fattyacid NA 0.00108 no no no dn no up TNF signaling pathway PUFA/MUFA+blood 0 0.538235294 0 kegg serum_fattyacid NA 0.00108 no no no dn no up Toll-like receptor signaling pathway PUFA/MUFA+blood 0 0.579411765 -0.5 yes kegg serum_fattyacid NA 0.00108 no no no dn no up Transcriptional misregulation in cancer PUFA/MUFA+blood 0 0 -0.420769231 kegg serum_fattyacid NA 0.00108 no no no dn no up Wnt signaling pathway PUFA/MUFA+blood 0 -0.608823529 0 kegg serum_fattyacid NA 0.00108 no no no dn no up 13-HODE+blood PUFA/UFA+blood 0 0.531862745 0 serum_ARA serum_fattyacid 0.32 0.000732 no no no dn no up 16:0/14:0-PC+blood PUFA/UFA+blood 0.533834586 0 0.45025641 serum_phospholipids serum_fattyacid 0.0206 0.000732 no up up dn no up 16:0/16:0-PC+blood PUFA/UFA+blood 0.505263158 0 0 serum_phospholipids serum_fattyacid 0.00079 0.000732 no up up dn no up 16:0/16:0-PI+blood PUFA/UFA+blood -0.535338346 0 0 serum_phospholipids serum_fattyacid 0.358 0.000732 no no no dn no up 16:0/16:1-PI+blood PUFA/UFA+blood -0.598496241 0 0 serum_phospholipids serum_fattyacid 0.262 0.000732 no no no dn no up 16:0/18:1-PC+blood PUFA/UFA+blood 0.673684211 0 0 serum_phospholipids serum_fattyacid 6.15E-07 0.000732 up up up dn no up 16:0/18:1-PE+blood PUFA/UFA+blood 0 0 -0.424273504 serum_phospholipids serum_fattyacid 0.000107 0.000732 up up no dn no up 16:0/18:2-PC+blood PUFA/UFA+blood 0.679699248 0.659313725 0.514529915 serum_phospholipids serum_fattyacid 3.24E-06 0.000732 no up up dn no up 16:0/18:2-PI+blood PUFA/UFA+blood -0.472180451 0 0 serum_phospholipids serum_fattyacid 0.269 0.000732 no no no dn no up 16:0/20:3-PC+blood PUFA/UFA+blood 0.542857143 0 0.411965812 serum_phospholipids serum_fattyacid 5.43E-06 0.000732 no up up dn no up 16:0/20:4-PC+blood PUFA/UFA+blood 0.57593985 0 0 serum_phospholipids serum_fattyacid 0.0262 0.000732 no up no dn no up 16:0/20:4-PE+blood PUFA/UFA+blood 0 0 -0.500854701 serum_phospholipids serum_fattyacid 0.00139 0.000732 up up no dn no up 16:0/20:4-PI+blood PUFA/UFA+blood -0.603007519 -0.556372549 0 serum_phospholipids serum_fattyacid 0.558 0.000732 no no no dn no up 16:0/22:0-PE+blood PUFA/UFA+blood 0 0 0.520683761 serum_phospholipids serum_fattyacid 0.00839 0.000732 dn no up dn no up 16:0/22:6-PC+blood PUFA/UFA+blood 0 0 0.597264957 serum_phospholipids serum_fattyacid 4.53E-05 0.000732 no up up dn no up 16:1/16:0-PC+blood PUFA/UFA+blood 0.578947368 0 0 serum_phospholipids serum_fattyacid 0.0215 0.000732 no up up dn no up 18:0-LPA+blood PUFA/UFA+blood 0 0.531862745 0 serum_phospholipids serum_fattyacid 0.0725 0.000732 no dn no dn no up 18:0-LPE+blood PUFA/UFA+blood -0.508270677 0 -0.461880342 serum_phospholipids serum_fattyacid 0.491 0.000732 no no no dn no up 18:0/16:0-PC+blood PUFA/UFA+blood 0.655639098 0 0 serum_phospholipids serum_fattyacid 9.64E-07 0.000732 up up up dn no up 18:0/18:0-PE+blood PUFA/UFA+blood -0.484210526 0 -0.460512821 serum_phospholipids serum_fattyacid 0.00896 0.000732 up up no dn no up 18:0/18:0-PS+blood PUFA/UFA+blood 0 -0.553921569 0 serum_phospholipids serum_fattyacid 0.00617 0.000732 no up no dn no up 18:0/18:1-PE+blood PUFA/UFA+blood -0.506766917 0 -0.526837607 serum_phospholipids serum_fattyacid 0.00716 0.000732 up up no dn no up 18:0/18:1-PG+blood PUFA/UFA+blood 0 0 -0.593162393 serum_phospholipids serum_fattyacid 0.000842 0.000732 no up no dn no up 18:0/18:2-PC+blood PUFA/UFA+blood 0.578947368 0 0.614358974 serum_phospholipids serum_fattyacid 1.74E-06 0.000732 no up up dn no up 18:0/20:4-PC+blood PUFA/UFA+blood 0.527819549 0 0 serum_phospholipids serum_fattyacid 0.454 0.000732 no no no dn no up 18:0/20:5-PC+blood PUFA/UFA+blood 0.47518797 0 0 serum_phospholipids serum_fattyacid 0.17 0.000732 no no no dn no up 18:1/16:0-PC+blood PUFA/UFA+blood 0.682706767 0.659313725 0.504273504 serum_phospholipids serum_fattyacid 2.43E-05 0.000732 no up up dn no up 18:1/16:0-PE+blood PUFA/UFA+blood 0 0 -0.598632479 serum_phospholipids serum_fattyacid 0.000182 0.000732 up up no dn no up 18:1/16:0-PI+blood PUFA/UFA+blood -0.485714286 0 0 serum_phospholipids serum_fattyacid 0.793 0.000732 no no no dn no up 18:1/16:1-PE+blood PUFA/UFA+blood 0 0 -0.511794872 serum_phospholipids serum_fattyacid 0.000184 0.000732 up up no dn no up 18:1/18:0-PC+blood PUFA/UFA+blood 0.618045113 0 0.625982906 serum_phospholipids serum_fattyacid 1.83E-06 0.000732 no up up dn no up 18:1/18:0-PE+blood PUFA/UFA+blood 0 0 -0.571965812 serum_phospholipids serum_fattyacid 1.39E-06 0.000732 up up no dn no up 18:1/18:0-PI+blood PUFA/UFA+blood -0.464661654 -0.5 0 serum_phospholipids serum_fattyacid 0.0931 0.000732 no no up dn no up 18:1/18:1-PC+blood PUFA/UFA+blood 0.503759398 0 0 serum_phospholipids serum_fattyacid 1.34E-05 0.000732 no up up dn no up 18:1/18:1-PE+blood PUFA/UFA+blood 0 0 -0.55965812 serum_phospholipids serum_fattyacid 1.03E-05 0.000732 up up no dn no up 18:1/18:2-PE+blood PUFA/UFA+blood 0 0 -0.632820513 serum_phospholipids serum_fattyacid 0.000293 0.000732 up up no dn no up 18:1/20:4-PE+blood PUFA/UFA+blood 0 0 -0.601367521 serum_phospholipids serum_fattyacid 0.0578 0.000732 up no no dn no up 18:2-LPA+blood PUFA/UFA+blood 0 0.517156863 0 serum_phospholipids serum_fattyacid 0.00684 0.000732 dn no up dn no up 18:2/16:0-PC+blood PUFA/UFA+blood 0.654135338 0.529411765 0.473504274 serum_phospholipids serum_fattyacid 8.67E-05 0.000732 no up up dn no up 18:3/16:0-PE+blood PUFA/UFA+blood 0 -0.49754902 -0.517264957 serum_phospholipids serum_fattyacid 0.00149 0.000732 up up no dn no up 18:3n6+blood PUFA/UFA+blood -0.508270677 0 0 serum_fattyacid serum_fattyacid 0.0463 0.000732 up no dn dn no up 20:0-LPE+blood PUFA/UFA+blood 0 -0.514705882 0 serum_phospholipids serum_fattyacid 0.0615 0.000732 no no up dn no up 20:0/20:4-PE+blood PUFA/UFA+blood 0 0 -0.515213675 serum_phospholipids serum_fattyacid 0.00128 0.000732 up up no dn no up 20:1-LPC+blood PUFA/UFA+blood 0 0 0.443418803 serum_phospholipids serum_fattyacid 0.217 0.000732 no no no dn no up 20:1/20:4-PC+blood PUFA/UFA+blood 0 0 0.432478632 serum_phospholipids serum_fattyacid 0.0419 0.000732 no no up dn no up 20:1/20:4-PE+blood PUFA/UFA+blood 0 0 -0.541880342 serum_phospholipids serum_fattyacid 0.0042 0.000732 up up no dn no up 20:2-LPC+blood PUFA/UFA+blood 0 0 0.511111111 serum_phospholipids serum_fattyacid 0.119 0.000732 no no up dn no up 20:2/18:1-PE+blood PUFA/UFA+blood -0.494736842 0 -0.40991453 serum_phospholipids serum_fattyacid 0.00208 0.000732 up up no dn no up 20:2+blood PUFA/UFA+blood 0 0.522058824 0 serum_fattyacid serum_fattyacid 0.478 0.000732 no no no dn no up 20:3/16:0-PC+blood PUFA/UFA+blood 0.587969925 0 0 serum_phospholipids serum_fattyacid 0.00405 0.000732 no up up dn no up 20:3/18:0-PC+blood PUFA/UFA+blood 0 0 0.48034188 serum_phospholipids serum_fattyacid 0.296 0.000732 no no no dn no up 20:3n6+blood PUFA/UFA+blood -0.464661654 0 0 serum_fattyacid serum_fattyacid 0.0884 0.000732 up no no dn no up 20:4-LPA+blood PUFA/UFA+blood 0 0.62254902 0 serum_phospholipids serum_fattyacid 0.398 0.000732 no no no dn no up 20:4/16:0-PE+blood PUFA/UFA+blood -0.496240602 0 -0.413333333 serum_phospholipids serum_fattyacid 0.00529 0.000732 no up up dn no up 20:4/18:0-PE+blood PUFA/UFA+blood 0 0 -0.495384615 serum_phospholipids serum_fattyacid 0.000755 0.000732 up up no dn no up 20:5/18:0-PC+blood PUFA/UFA+blood 0 0 0.636239316 serum_phospholipids serum_fattyacid 3.97E-06 0.000732 no up up dn no up 22:0/16:0-PE+blood PUFA/UFA+blood 0 0 0.475555556 serum_phospholipids serum_fattyacid 0.091 0.000732 no no up dn no up 22:1-LPA+blood PUFA/UFA+blood 0 0.519607843 0 serum_phospholipids serum_fattyacid 0.00373 0.000732 no up up dn no up 22:6n3+blood PUFA/UFA+blood 0 0 0.416752137 serum_fattyacid serum_fattyacid 0.792 0.000732 no no no dn no up 24:1+blood PUFA/UFA+blood 0 0 0.535726496 serum_fattyacid serum_fattyacid 0.00582 0.000732 no dn dn dn no up 5-HETE+blood PUFA/UFA+blood 0.492833698 0 0 serum_ARA serum_fattyacid 0.697 0.000732 no no no dn no up 8-HETE+blood PUFA/UFA+blood 0 0.495098039 0 serum_ARA serum_fattyacid 0.741 0.000732 no no no dn no up capric acid C6+blood PUFA/UFA+blood 0 0 0.475555556 serum_scfa serum_fattyacid 0.433 0.000732 no no no dn no up CDCA+blood PUFA/UFA+blood 0 -0.50245098 0 serum_bileacids serum_fattyacid 0.506 0.000732 no no no dn no up Choline+blood PUFA/UFA+blood 0 0.56127451 0 serum_choline serum_fattyacid 0.0395 0.000732 no up no dn no up Creatinine+blood PUFA/UFA+blood 0 0 0.418803419 serum_choline serum_fattyacid 0.437 0.000732 no no no dn no up Cysteine+blood PUFA/UFA+blood 0 0.546568627 0 yes serum_aminoacids serum_fattyacid 1.81E-07 0.000732 dn up up dn no up Cystine+blood PUFA/UFA+blood 0 0.676470588 0 yes serum_aminoacids serum_fattyacid 0.00028 0.000732 up up no dn no up d18:1-14:0-SM+blood PUFA/UFA+blood 0 -0.551470588 0 serum_phospholipids serum_fattyacid 0.94 0.000732 no no no dn no up d18:1-14:1-SM+blood PUFA/UFA+blood 0 -0.575980392 0 serum_phospholipids serum_fattyacid 0.0952 0.000732 no dn no dn no up d18:1-16:1-SM+blood PUFA/UFA+blood 0 0 -0.444102564 serum_phospholipids serum_fattyacid 0.2 0.000732 no no no dn no up d18:1-18:0-SM+blood PUFA/UFA+blood 0.532330827 0 0 serum_phospholipids serum_fattyacid 0.97 0.000732 no no no dn no up decanoic acid C10+blood PUFA/UFA+blood 0 0 0.474871795 serum_mcfa serum_fattyacid 6.64E-11 0.000732 dn dn no dn no up DHA+blood PUFA/UFA+blood 0 0.507352941 0 serum_ARA serum_fattyacid 0.872 0.000732 no no no dn no up Ethanolamine+blood PUFA/UFA+blood 0 0.740196078 0 serum_aminoacids serum_fattyacid 0.122 0.000732 up no no dn no up Glycine+blood PUFA/UFA+blood 0.569924812 0.715686275 0.597264957 serum_aminoacids serum_fattyacid 0.00408 0.000732 dn no up dn no up GPC+blood PUFA/UFA+blood 0 0.50245098 0 serum_choline serum_fattyacid 0.00427 0.000732 no up up dn no up GUDCA+blood PUFA/UFA+blood -0.44962406 0 0 serum_bileacids serum_fattyacid 0.0766 0.000732 no no dn dn no up HDCA+blood PUFA/UFA+blood 0.518101712 0 0 serum_bileacids serum_fattyacid 0.483 0.000732 no no no dn no up heptanoic acid C7+blood PUFA/UFA+blood 0 0 0.416752137 serum_mcfa serum_fattyacid 8.27E-11 0.000732 dn dn no dn no up iso-DCA+blood PUFA/UFA+blood 0.505263158 0 0 serum_bileacids serum_fattyacid 0.38 0.000732 no no no dn no up L-Arginine+blood PUFA/UFA+blood 0 0.573529412 0.593162393 serum_aminoacids serum_fattyacid 0.316 0.000732 no no no dn no up L-Asparagine+blood PUFA/UFA+blood 0 0.676470588 0.677948718 serum_aminoacids serum_fattyacid 0.784 0.000732 no no no dn no up L-Aspartic acid+blood PUFA/UFA+blood 0.589473684 0 0 yes serum_aminoacids serum_fattyacid 0.0226 0.000732 up up no dn no up L-Glutamic acid+blood PUFA/UFA+blood 0 0.595588235 0 yes serum_aminoacids serum_fattyacid 6.20E-05 0.000732 up up no dn no up L-Glutamine+blood PUFA/UFA+blood 0.529323308 0 0.708034188 serum_aminoacids serum_fattyacid 0.639 0.000732 no no no dn no up L-Histidine+blood PUFA/UFA+blood 0.497744361 0.551470588 0.528888889 serum_aminoacids serum_fattyacid 0.109 0.000732 no no no dn no up L-Leucine+blood PUFA/UFA+blood 0 0 0.401025641 yes serum_aminoacids serum_fattyacid 3.22E-05 0.000732 up up no dn no up L-Lysine+blood PUFA/UFA+blood 0 0.674019608 0 yes serum_aminoacids serum_fattyacid 0.0107 0.000732 no up no dn no up L-Methionine+blood PUFA/UFA+blood 0 0.541666667 0 serum_aminoacids serum_fattyacid 0.626 0.000732 no no no dn no up L-Phenylalanine+blood PUFA/UFA+blood 0 0.5 0 yes serum_aminoacids serum_fattyacid 0.0103 0.000732 up up no dn no up L-Tryptophan+blood PUFA/UFA+blood 0 0 0.45982906 serum_aminoacids serum_fattyacid 0.164 0.000732 no no no dn no up MUFA%+blood PUFA/UFA+blood 0.556390977 0.683823529 0.442051282 serum_fattyacid serum_fattyacid 0.00142 0.000732 up no dn dn no up n6/n3+blood PUFA/UFA+blood 0 0.526960784 0 serum_fattyacid serum_fattyacid 0.226 0.000732 no no no dn no up octanoic acid C8+blood PUFA/UFA+blood 0 0 0.643760684 serum_mcfa serum_fattyacid 2.84E-11 0.000732 dn dn dn dn no up PUFA/MUFA+blood PUFA/UFA+blood 0.807518797 0.830882353 0.749059829 serum_fattyacid serum_fattyacid 0.00108 0.000732 dn no up dn no up 13-HODE+blood PUFA%+blood 0 0.578431373 0 serum_ARA serum_fattyacid 0.32 0.0013 no no no dn no up 16:0-LPE+blood PUFA%+blood 0 0 -0.436581197 serum_phospholipids serum_fattyacid 0.0711 0.0013 up up no dn no up 16:0/14:0-PC+blood PUFA%+blood 0.562406015 0 0.462564103 serum_phospholipids serum_fattyacid 0.0206 0.0013 no up up dn no up 16:0/16:0-PC+blood PUFA%+blood 0.553383459 0 0 serum_phospholipids serum_fattyacid 0.00079 0.0013 no up up dn no up 16:0/16:0-PI+blood PUFA%+blood -0.583458647 0 -0.461196581 serum_phospholipids serum_fattyacid 0.358 0.0013 no no no dn no up 16:0/16:1-PI+blood PUFA%+blood -0.720300752 -0.531862745 -0.547350427 serum_phospholipids serum_fattyacid 0.262 0.0013 no no no dn no up 16:0/18:0-PC+blood PUFA%+blood 0 0 0.465299145 serum_phospholipids serum_fattyacid 0.521 0.0013 no no no dn no up 16:0/18:1-PC+blood PUFA%+blood 0.697744361 0 0 serum_phospholipids serum_fattyacid 6.15E-07 0.0013 up up up dn no up 16:0/18:1-PE+blood PUFA%+blood -0.470676692 0 -0.511111111 serum_phospholipids serum_fattyacid 0.000107 0.0013 up up no dn no up 16:0/18:2-PC+blood PUFA%+blood 0.685714286 0.664215686 0.496752137 serum_phospholipids serum_fattyacid 3.24E-06 0.0013 no up up dn no up 16:0/18:2-PI+blood PUFA%+blood -0.52481203 0 -0.42017094 serum_phospholipids serum_fattyacid 0.269 0.0013 no no no dn no up 16:0/20:3-PC+blood PUFA%+blood 0.607518797 0 0.405128205 serum_phospholipids serum_fattyacid 5.43E-06 0.0013 no up up dn no up 16:0/20:4-PC+blood PUFA%+blood 0.64962406 0 0 serum_phospholipids serum_fattyacid 0.0262 0.0013 no up no dn no up 16:0/20:4-PE+blood PUFA%+blood 0 0 -0.526153846 serum_phospholipids serum_fattyacid 0.00139 0.0013 up up no dn no up 16:0/20:4-PI+blood PUFA%+blood -0.645112782 -0.56372549 -0.487179487 serum_phospholipids serum_fattyacid 0.558 0.0013 no no no dn no up 16:0/22:0-PE+blood PUFA%+blood 0 0 0.597264957 serum_phospholipids serum_fattyacid 0.00839 0.0013 dn no up dn no up 16:0/22:6-PC+blood PUFA%+blood 0.463157895 0 0.653333333 serum_phospholipids serum_fattyacid 4.53E-05 0.0013 no up up dn no up 16:0/22:6-PE+blood PUFA%+blood 0 0 -0.436581197 serum_phospholipids serum_fattyacid 0.000934 0.0013 up up no dn no up 16:1/16:0-PC+blood PUFA%+blood 0.636090226 0 0 serum_phospholipids serum_fattyacid 0.0215 0.0013 no up up dn no up 16:1/16:1-PC+blood PUFA%+blood 0.533834586 0 0 serum_phospholipids serum_fattyacid 0.0177 0.0013 no no up dn no up 18:0-LPA+blood PUFA%+blood 0 0.544117647 0 serum_phospholipids serum_fattyacid 0.0725 0.0013 no dn no dn no up 18:0-LPE+blood PUFA%+blood -0.473684211 0 0 serum_phospholipids serum_fattyacid 0.491 0.0013 no no no dn no up 18:0/16:0-PC+blood PUFA%+blood 0.678195489 0.485294118 0 serum_phospholipids serum_fattyacid 9.64E-07 0.0013 up up up dn no up 18:0/18:0-PE+blood PUFA%+blood -0.512781955 0 -0.431111111 serum_phospholipids serum_fattyacid 0.00896 0.0013 up up no dn no up 18:0/18:0-PS+blood PUFA%+blood 0 -0.575980392 0 serum_phospholipids serum_fattyacid 0.00617 0.0013 no up no dn no up 18:0/18:1-PE+blood PUFA%+blood -0.556390977 0 -0.513846154 serum_phospholipids serum_fattyacid 0.00716 0.0013 up up no dn no up 18:0/18:1-PG+blood PUFA%+blood 0 0 -0.645128205 serum_phospholipids serum_fattyacid 0.000842 0.0013 no up no dn no up 18:0/18:2-PC+blood PUFA%+blood 0.639097744 0 0.675213675 serum_phospholipids serum_fattyacid 1.74E-06 0.0013 no up up dn no up 18:0/20:2-PC+blood PUFA%+blood 0 0 0.453675214 serum_phospholipids serum_fattyacid 0.733 0.0013 no no no dn no up 18:0/20:4-PC+blood PUFA%+blood 0.618045113 0 0 serum_phospholipids serum_fattyacid 0.454 0.0013 no no no dn no up 18:0/20:5-PC+blood PUFA%+blood 0.526315789 0 0 serum_phospholipids serum_fattyacid 0.17 0.0013 no no no dn no up 18:1-LPE+blood PUFA%+blood -0.461654135 0 0 serum_phospholipids serum_fattyacid 0.117 0.0013 no no no dn no up 18:1/16:0-PC+blood PUFA%+blood 0.691729323 0.664215686 0.501538462 serum_phospholipids serum_fattyacid 2.43E-05 0.0013 no up up dn no up 18:1/16:0-PE+blood PUFA%+blood -0.473684211 0 -0.664957265 serum_phospholipids serum_fattyacid 0.000182 0.0013 up up no dn no up 18:1/16:0-PI+blood PUFA%+blood -0.536842105 0 0 serum_phospholipids serum_fattyacid 0.793 0.0013 no no no dn no up 18:1/16:1-PE+blood PUFA%+blood -0.509774436 0 -0.587008547 serum_phospholipids serum_fattyacid 0.000184 0.0013 up up no dn no up 18:1/18:0-PC+blood PUFA%+blood 0.663157895 0 0.679316239 serum_phospholipids serum_fattyacid 1.83E-06 0.0013 no up up dn no up 18:1/18:0-PE+blood PUFA%+blood 0 0 -0.575384615 serum_phospholipids serum_fattyacid 1.39E-06 0.0013 up up no dn no up 18:1/18:0-PI+blood PUFA%+blood 0 -0.517156863 0 serum_phospholipids serum_fattyacid 0.0931 0.0013 no no up dn no up 18:1/18:1-PC+blood PUFA%+blood 0.514285714 0 0 serum_phospholipids serum_fattyacid 1.34E-05 0.0013 no up up dn no up 18:1/18:1-PE+blood PUFA%+blood 0 0 -0.535042735 serum_phospholipids serum_fattyacid 1.03E-05 0.0013 up up no dn no up 18:1/18:2-PE+blood PUFA%+blood 0 0 -0.601367521 serum_phospholipids serum_fattyacid 0.000293 0.0013 up up no dn no up 18:1/20:4-PC+blood PUFA%+blood 0.485714286 0 0 serum_phospholipids serum_fattyacid 0.582 0.0013 no no no dn no up 18:1/20:4-PE+blood PUFA%+blood 0 0 -0.517264957 serum_phospholipids serum_fattyacid 0.0578 0.0013 up no no dn no up 18:2-LPA+blood PUFA%+blood 0 0.522058824 0 serum_phospholipids serum_fattyacid 0.00684 0.0013 dn no up dn no up 18:2/16:0-PC+blood PUFA%+blood 0.723308271 0.573529412 0.487179487 serum_phospholipids serum_fattyacid 8.67E-05 0.0013 no up up dn no up 18:3/16:0-PE+blood PUFA%+blood -0.472180451 -0.49754902 -0.695726496 serum_phospholipids serum_fattyacid 0.00149 0.0013 up up no dn no up 18:3n6+blood PUFA%+blood -0.55037594 -0.524509804 0 serum_fattyacid serum_fattyacid 0.0463 0.0013 up no dn dn no up 20:0-LPE+blood PUFA%+blood 0 -0.522058824 0 serum_phospholipids serum_fattyacid 0.0615 0.0013 no no up dn no up 20:0/20:4-PE+blood PUFA%+blood 0 -0.490196078 -0.458461538 serum_phospholipids serum_fattyacid 0.00128 0.0013 up up no dn no up 20:1-LPC+blood PUFA%+blood 0 0 0.541196581 serum_phospholipids serum_fattyacid 0.217 0.0013 no no no dn no up 20:1/20:4-PC+blood PUFA%+blood 0 0 0.500854701 serum_phospholipids serum_fattyacid 0.0419 0.0013 no no up dn no up 20:1/20:4-PE+blood PUFA%+blood 0 -0.485294118 -0.517264957 serum_phospholipids serum_fattyacid 0.0042 0.0013 up up no dn no up 20:2-LPC+blood PUFA%+blood 0 0 0.525470085 serum_phospholipids serum_fattyacid 0.119 0.0013 no no up dn no up 20:2/18:1-PE+blood PUFA%+blood -0.494736842 0 -0.431794872 serum_phospholipids serum_fattyacid 0.00208 0.0013 up up no dn no up 20:2+blood PUFA%+blood 0 0.487745098 0.45982906 serum_fattyacid serum_fattyacid 0.478 0.0013 no no no dn no up 20:3/16:0-PC+blood PUFA%+blood 0.64962406 0 0 serum_phospholipids serum_fattyacid 0.00405 0.0013 no up up dn no up 20:3/18:0-PC+blood PUFA%+blood 0 0 0.595897436 serum_phospholipids serum_fattyacid 0.296 0.0013 no no no dn no up 20:3n6+blood PUFA%+blood -0.44962406 0 0 serum_fattyacid serum_fattyacid 0.0884 0.0013 up no no dn no up 20:4-LPA+blood PUFA%+blood 0 0.62745098 0 serum_phospholipids serum_fattyacid 0.398 0.0013 no no no dn no up 20:4/16:0-PE+blood PUFA%+blood -0.481203008 0 -0.418119658 serum_phospholipids serum_fattyacid 0.00529 0.0013 no up up dn no up 20:4/18:0-PE+blood PUFA%+blood 0 0 -0.435213675 serum_phospholipids serum_fattyacid 0.000755 0.0013 up up no dn no up 20:5/18:0-PC+blood PUFA%+blood 0 0 0.71008547 serum_phospholipids serum_fattyacid 3.97E-06 0.0013 no up up dn no up 22:0/16:0-PE+blood PUFA%+blood 0 0 0.584273504 serum_phospholipids serum_fattyacid 0.091 0.0013 no no up dn no up 22:1-LPA+blood PUFA%+blood 0 0.514705882 0 serum_phospholipids serum_fattyacid 0.00373 0.0013 no up up dn no up 22:6n3+blood PUFA%+blood 0 0 0.457777778 serum_fattyacid serum_fattyacid 0.792 0.0013 no no no dn no up 24:1+blood PUFA%+blood 0 0 0.488547009 serum_fattyacid serum_fattyacid 0.00582 0.0013 no dn dn dn no up 5-HETE+blood PUFA%+blood 0.492078975 0 0 serum_ARA serum_fattyacid 0.697 0.0013 no no no dn no up 8-HETE+blood PUFA%+blood 0 0.553921569 0 serum_ARA serum_fattyacid 0.741 0.0013 no no no dn no up Adrenergic signaling in cardiomyocytes PUFA%+blood 0 -0.502941176 0 kegg serum_fattyacid NA 0.0013 no no up dn no up Aldosterone synthesis and secretion PUFA%+blood 0 -0.529411765 0 kegg serum_fattyacid NA 0.0013 no up up dn no up Allograft rejection PUFA%+blood 0 0.526470588 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Amphetamine addiction PUFA%+blood 0 -0.614705882 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Apelin signaling pathway PUFA%+blood 0 -0.511764706 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Apoptosis PUFA%+blood 0.494736842 0.567647059 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Autoimmune thyroid disease PUFA%+blood 0 0.526470588 0 kegg serum_fattyacid NA 0.0013 no no no dn no up B cell receptor signaling pathway PUFA%+blood 0 0.532352941 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Betaine+blood PUFA%+blood 0 0 0.45982906 serum_choline serum_fattyacid 0.857 0.0013 no no no dn no up Biosynthesis of amino acids PUFA%+blood 0 0.597058824 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Bladder cancer PUFA%+blood 0 0.520588235 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Breast cancer PUFA%+blood 0 0 -0.497692308 kegg serum_fattyacid NA 0.0013 no no no dn no up C-type lectin receptor signaling pathway PUFA%+blood 0 0.529411765 0 kegg serum_fattyacid NA 0.0013 no no no dn no up capric acid C6+blood PUFA%+blood 0 0 0.58017094 serum_scfa serum_fattyacid 0.433 0.0013 no no no dn no up Carbon metabolism PUFA%+blood 0 0 0.404615385 kegg serum_fattyacid NA 0.0013 no no no dn no up Cardiac muscle contraction PUFA%+blood 0 0 -0.440769231 kegg serum_fattyacid NA 0.0013 no no up dn no up CDCA+blood PUFA%+blood 0 -0.522058824 0 serum_bileacids serum_fattyacid 0.506 0.0013 no no no dn no up Cell adhesion molecules PUFA%+blood 0 0.561764706 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Cell cycle PUFA%+blood 0 -0.747058824 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Cellular senescence PUFA%+blood 0 0.6 0 kegg serum_fattyacid NA 0.0013 no no no dn no up cGMP-PKG signaling pathway PUFA%+blood 0 0.6 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Chagas disease PUFA%+blood 0 0.502941176 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Chemokine signaling pathway PUFA%+blood 0 0.573529412 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Choline metabolism in cancer PUFA%+blood 0 0 -0.436153846 kegg serum_fattyacid NA 0.0013 no no no dn no up Choline+blood PUFA%+blood 0 0.56127451 0 serum_choline serum_fattyacid 0.0395 0.0013 no up no dn no up Colorectal cancer PUFA%+blood 0 -0.547058824 -0.512307692 kegg serum_fattyacid NA 0.0013 no no no dn no up Creatinine+blood PUFA%+blood 0.470676692 0.492647059 0 serum_choline serum_fattyacid 0.437 0.0013 no no no dn no up Cysteine+blood PUFA%+blood 0 0.524509804 0 yes serum_aminoacids serum_fattyacid 1.81E-07 0.0013 dn up up dn no up Cystine+blood PUFA%+blood 0 0.62745098 0 yes serum_aminoacids serum_fattyacid 0.00028 0.0013 up up no dn no up Cytosolic DNA-sensing pathway PUFA%+blood 0.526315789 0 0 kegg serum_fattyacid NA 0.0013 no no no dn no up d18:1-14:0-SM+blood PUFA%+blood 0 -0.571078431 0 serum_phospholipids serum_fattyacid 0.94 0.0013 no no no dn no up d18:1-14:1-SM+blood PUFA%+blood 0 -0.62745098 0 serum_phospholipids serum_fattyacid 0.0952 0.0013 no dn no dn no up d18:1-18:0-SM+blood PUFA%+blood 0.593984962 0 0 serum_phospholipids serum_fattyacid 0.97 0.0013 no no no dn no up DCA+stool PUFA%+blood 0 0 -0.49924812 stool_bileacids serum_fattyacid 0.195 0.0013 no no no dn no up decanoic acid C10+blood PUFA%+blood 0 0 0.541196581 serum_mcfa serum_fattyacid 6.64E-11 0.0013 dn dn no dn no up DHA+blood PUFA%+blood 0 0.558823529 0 serum_ARA serum_fattyacid 0.872 0.0013 no no no dn no up DPA+blood PUFA%+blood 0 0.514705882 0 serum_ARA serum_fattyacid 0.519 0.0013 no no no dn no up EGFR tyrosine kinase inhibitor resistance PUFA%+blood 0 -0.538235294 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Endocrine resistance PUFA%+blood 0 0 -0.414615385 kegg serum_fattyacid NA 0.0013 no no no dn no up Endocytosis PUFA%+blood 0 0.617647059 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Epithelial cell signaling in Helicobacter pylori infection PUFA%+blood 0.470175439 0.670588235 0 kegg serum_fattyacid NA 0.0013 no no no dn no up ErbB signaling pathway PUFA%+blood 0 0 -0.42 kegg serum_fattyacid NA 0.0013 no no no dn no up Estrogen signaling pathway PUFA%+blood 0 -0.502941176 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Ethanolamine+blood PUFA%+blood 0.452631579 0.727941176 0 serum_aminoacids serum_fattyacid 0.122 0.0013 up no no dn no up Fc gamma R-mediated phagocytosis PUFA%+blood 0 0.567647059 0 kegg serum_fattyacid NA 0.0013 no no no dn no up GCDCA+blood PUFA%+blood -0.44962406 0 0 serum_bileacids serum_fattyacid 0.31 0.0013 no no no dn no up Glucagon signaling pathway PUFA%+blood 0 -0.544117647 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Glycine+blood PUFA%+blood 0.586466165 0.703431373 0.589059829 serum_aminoacids serum_fattyacid 0.00408 0.0013 dn no up dn no up Glycolysis / Gluconeogenesis PUFA%+blood 0 0 0.423846154 kegg serum_fattyacid NA 0.0013 no no no dn no up GPC+blood PUFA%+blood 0 0.519607843 0 serum_choline serum_fattyacid 0.00427 0.0013 no up up dn no up Graft-versus-host disease PUFA%+blood 0 0.526470588 0 kegg serum_fattyacid NA 0.0013 no no no dn no up "Growth hormone synthesis, secretion and action" PUFA%+blood 0 0 -0.483846154 kegg serum_fattyacid NA 0.0013 no no no dn no up GUDCA+blood PUFA%+blood -0.538345865 0 0 serum_bileacids serum_fattyacid 0.0766 0.0013 no no dn dn no up HDCA+blood PUFA%+blood 0.518101712 0 0 serum_bileacids serum_fattyacid 0.483 0.0013 no no no dn no up Hepatitis B PUFA%+blood 0 0 -0.497692308 kegg serum_fattyacid NA 0.0013 no no no dn no up Human papillomavirus infection PUFA%+blood 0 0.547058824 0 kegg serum_fattyacid NA 0.0013 no no no dn no up IL-17 signaling pathway PUFA%+blood 0 0.573529412 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Inflammatory mediator regulation of TRP channels PUFA%+blood 0 -0.511764706 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Influenza A PUFA%+blood 0.528070175 0 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Insulin signaling pathway PUFA%+blood 0 -0.547058824 0 kegg serum_fattyacid NA 0.0013 no no no dn no up iso-DCA+blood PUFA%+blood 0.578947368 0 0 serum_bileacids serum_fattyacid 0.38 0.0013 no no no dn no up L-Arginine+blood PUFA%+blood 0 0.56127451 0.552820513 serum_aminoacids serum_fattyacid 0.316 0.0013 no no no dn no up L-Asparagine+blood PUFA%+blood 0 0.68627451 0.651965812 serum_aminoacids serum_fattyacid 0.784 0.0013 no no no dn no up L-Aspartic acid+blood PUFA%+blood 0.563909774 0 0 yes serum_aminoacids serum_fattyacid 0.0226 0.0013 up up no dn no up L-Glutamic acid+blood PUFA%+blood 0 0.610294118 0 yes serum_aminoacids serum_fattyacid 6.20E-05 0.0013 up up no dn no up L-Glutamine+blood PUFA%+blood 0.539849624 0 0.757948718 serum_aminoacids serum_fattyacid 0.639 0.0013 no no no dn no up L-Histidine+blood PUFA%+blood 0.509774436 0.524509804 0.439316239 serum_aminoacids serum_fattyacid 0.109 0.0013 no no no dn no up L-Lysine+blood PUFA%+blood 0 0.625 0 yes serum_aminoacids serum_fattyacid 0.0107 0.0013 no up no dn no up L-Methionine+blood PUFA%+blood 0 0.524509804 0 serum_aminoacids serum_fattyacid 0.626 0.0013 no no no dn no up L-Phenylalanine+stool PUFA%+blood 0 0 0.502255639 stool_cometabolism serum_fattyacid 0.398 0.0013 no no no dn no up L-Tryptophan+blood PUFA%+blood 0 0 0.433162393 serum_aminoacids serum_fattyacid 0.164 0.0013 no no no dn no up L-Tyrosine+stool PUFA%+blood 0.587912088 0 0.551879699 stool_cometabolism serum_fattyacid 0.44 0.0013 no no no dn no up lauric acid C12+blood PUFA%+blood 0.473684211 0 0 serum_mcfa serum_fattyacid 0.015 0.0013 no dn dn dn no up Lipid and atherosclerosis PUFA%+blood 0 0.758823529 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Long-term potentiation PUFA%+blood 0 -0.555882353 0 kegg serum_fattyacid NA 0.0013 no no up dn no up Longevity regulating pathway - multiple species PUFA%+blood -0.557894737 0 0 kegg serum_fattyacid NA 0.0013 no no no dn no up MicroRNAs in cancer PUFA%+blood 0 0 -0.483076923 kegg serum_fattyacid NA 0.0013 no no no dn no up mRNA surveillance pathway PUFA%+blood 0 -0.747058824 0 kegg serum_fattyacid NA 0.0013 no no no dn no up mTOR signaling pathway PUFA%+blood 0 -0.532352941 0 kegg serum_fattyacid NA 0.0013 no no no dn no up MUFA%+blood PUFA%+blood 0.643609023 0.708333333 0.495384615 serum_fattyacid serum_fattyacid 0.00142 0.0013 up no dn dn no up n6/n3+blood PUFA%+blood 0 0.50245098 0 serum_fattyacid serum_fattyacid 0.226 0.0013 no no no dn no up Natural killer cell mediated cytotoxicity PUFA%+blood 0 0.597058824 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Neuroactive ligand-receptor interaction PUFA%+blood 0 0.502941176 0 kegg serum_fattyacid NA 0.0013 up up up dn no up Neutrophil extracellular trap formation PUFA%+blood 0 0.523529412 0 kegg serum_fattyacid NA 0.0013 no no no dn no up NOD-like receptor signaling pathway PUFA%+blood 0 0.617647059 0 kegg serum_fattyacid NA 0.0013 no no no dn no up octanoic acid C8+blood PUFA%+blood 0 0 0.668376068 serum_mcfa serum_fattyacid 2.84E-11 0.0013 dn dn dn dn no up Olfactory transduction PUFA%+blood 0 0.576470588 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Oocyte meiosis PUFA%+blood 0 -0.579411765 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Osteoclast differentiation PUFA%+blood 0 0.573529412 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Pancreatic cancer PUFA%+blood 0 0 -0.411538462 kegg serum_fattyacid NA 0.0013 no no no dn no up Pathogenic Escherichia coli infection PUFA%+blood 0 0.652941176 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Pertussis PUFA%+blood 0 0.605882353 0 kegg serum_fattyacid NA 0.0013 no no dn dn no up Phagosome PUFA%+blood 0 0.573529412 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Phosphatidylinositol signaling system PUFA%+blood 0 -0.523529412 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Prevotella PUFA%+blood -0.584713542 0 0 acetate-producing Genus serum_fattyacid 0.287 0.0013 no no no dn no up Propionic acid+stool PUFA%+blood 0 0 -0.473684211 yes stool_scfa serum_fattyacid 0.0436 0.0013 dn no up dn no up Protein processing in endoplasmic reticulum PUFA%+blood 0 -0.685294118 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Proteoglycans in cancer PUFA%+blood 0 -0.547058824 0 kegg serum_fattyacid NA 0.0013 no no no dn no up PUFA/MUFA+blood PUFA%+blood 0.730827068 0.816176471 0.688888889 serum_fattyacid serum_fattyacid 0.00108 0.0013 dn no up dn no up PUFA/UFA+blood PUFA%+blood 0.971428571 0.990196078 0.932991453 serum_fattyacid serum_fattyacid 0.000732 0.0013 dn no up dn no up Ras signaling pathway PUFA%+blood 0 -0.682352941 0 yes kegg serum_fattyacid NA 0.0013 no up up dn no up Rheumatoid arthritis PUFA%+blood 0 0.561764706 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Ribosome biogenesis in eukaryotes PUFA%+blood 0 -0.576470588 0 kegg serum_fattyacid NA 0.0013 no no no dn no up RNA degradation PUFA%+blood 0 -0.605882353 0 kegg serum_fattyacid NA 0.0013 no no no dn no up RNA transport PUFA%+blood 0 -0.508823529 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Salmonella infection PUFA%+blood 0 0.511764706 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Spinocerebellar ataxia PUFA%+blood 0 -0.620588235 0 kegg serum_fattyacid NA 0.0013 no no no dn no up TCA+stool PUFA%+blood -0.629986841 0 0 stool_bileacids serum_fattyacid 0.458 0.0013 no no no dn no up Th1 and Th2 cell differentiation PUFA%+blood 0.464912281 0 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Toll-like receptor signaling pathway PUFA%+blood 0 0.602941176 0 yes kegg serum_fattyacid NA 0.0013 no no no dn no up Transcriptional misregulation in cancer PUFA%+blood 0 0 -0.617692308 kegg serum_fattyacid NA 0.0013 no no no dn no up Tuberculosis PUFA%+blood 0 0.523529412 0 kegg serum_fattyacid NA 0.0013 no no dn dn no up Type I diabetes mellitus PUFA%+blood 0 0.526470588 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Viral carcinogenesis PUFA%+blood 0 0.597058824 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Wnt signaling pathway PUFA%+blood 0 -0.705882353 0 kegg serum_fattyacid NA 0.0013 no no no dn no up Yersinia infection PUFA%+blood 0 0.582352941 0 kegg serum_fattyacid NA 0.0013 no no no dn no up 12-HEPE+blood PUFA+blood -0.522488056 0 0 serum_ARA serum_fattyacid 0.312 0.212 no no no no no no 12-ketoDCA+blood PUFA+blood -0.494738073 0 0 serum_bileacids serum_fattyacid 0.517 0.212 no no no no no no 14:0/18:2-PC+blood PUFA+blood 0 0 0.414017094 serum_phospholipids serum_fattyacid 0.102 0.212 no up no no no no 14:0+blood PUFA+blood 0.619548872 0 0.523418803 yes serum_fattyacid serum_fattyacid 0.00572 0.212 up no dn no no no 16:0/16:0-PI+blood PUFA+blood 0 -0.529411765 0 serum_phospholipids serum_fattyacid 0.358 0.212 no no no no no no 16:0/18:0-PC+blood PUFA+blood 0 0 0.40034188 serum_phospholipids serum_fattyacid 0.521 0.212 no no no no no no 16:0/20:4-PI+blood PUFA+blood 0 -0.49754902 0 serum_phospholipids serum_fattyacid 0.558 0.212 no no no no no no 16:0/20:5-PG+blood PUFA+blood 0 0 -0.402393162 serum_phospholipids serum_fattyacid 0.00656 0.212 no up no no no no 16:0+blood PUFA+blood 0.876691729 0.828431373 0.646495726 yes serum_fattyacid serum_fattyacid 0.00876 0.212 up no no no no no 16:1/18:2-PG+blood PUFA+blood 0 0 -0.423589744 serum_phospholipids serum_fattyacid 1.40E-08 0.212 no up up no no no 16:1+blood PUFA+blood 0.631578947 0 0 yes serum_fattyacid serum_fattyacid 0.0186 0.212 no no dn no no no 18:0/20:4-PI+blood PUFA+blood 0 0.5 0 serum_phospholipids serum_fattyacid 0.167 0.212 no no no no no no 18:0+blood PUFA+blood 0.778947368 0.742647059 0.625299145 serum_fattyacid serum_fattyacid 0.344 0.212 no no no no no no 18:1/18:0-PS+blood PUFA+blood 0 0.632352941 0 serum_phospholipids serum_fattyacid 0.193 0.212 no no no no no no 18:1/18:1-PG+blood PUFA+blood 0 0 -0.502905983 serum_phospholipids serum_fattyacid 0.00352 0.212 no up up no no no 18:1+blood PUFA+blood 0.735338346 0.534313725 0.43042735 yes serum_fattyacid serum_fattyacid 0.00202 0.212 up no dn no no no 18:2/16:0-PC+blood PUFA+blood 0 0.517156863 0 serum_phospholipids serum_fattyacid 8.67E-05 0.212 no up up no no no 18:2n6c+blood PUFA+blood 0.706766917 0.789215686 0.798974359 serum_fattyacid serum_fattyacid 0.15 0.212 no no no no no no 18:3n3+blood PUFA+blood 0.616541353 0 0.401025641 serum_fattyacid serum_fattyacid 0.291 0.212 no no no no no no 20:1-LPA+blood PUFA+blood 0 0 -0.450940171 serum_phospholipids serum_fattyacid 0.0187 0.212 dn dn no no no no 20:2/18:3-PE+blood PUFA+blood 0 0.531862745 0 serum_phospholipids serum_fattyacid 0.0391 0.212 up up no no no no 20:3/16:0-PC+blood PUFA+blood 0 0.490196078 0 serum_phospholipids serum_fattyacid 0.00405 0.212 no up up no no no 20:3/18:0-PC+blood PUFA+blood 0.521804511 0 0 serum_phospholipids serum_fattyacid 0.296 0.212 no no no no no no 20:4-LPE+blood PUFA+blood 0 0.526960784 0 serum_phospholipids serum_fattyacid 0.552 0.212 no no no no no no 20:4/18:0-PE+blood PUFA+blood 0 0.490196078 0 serum_phospholipids serum_fattyacid 0.000755 0.212 up up no no no no 20:4n6+blood PUFA+blood 0 0.612745098 0 serum_fattyacid serum_fattyacid 0.133 0.212 no no no no no no 22:6n3+blood PUFA+blood 0.488721805 0 0 serum_fattyacid serum_fattyacid 0.792 0.212 no no no no no no 24:1+blood PUFA+blood 0 0.482843137 0 serum_fattyacid serum_fattyacid 0.00582 0.212 no dn dn no no no 3-(3-Hydroxyphenyl)propanoic acid+stool PUFA+blood 0.587912088 0 0 stool_cometabolism serum_fattyacid 0.33 0.212 no no no no no no AA+blood PUFA+blood 0.497744361 0 0 serum_ARA serum_fattyacid 0.212 0.212 no no no no no no Adipocytokine signaling pathway PUFA+blood 0 0 0.445384615 kegg serum_fattyacid NA 0.212 no no no no no no AGE-RAGE signaling pathway in diabetic complications PUFA+blood 0.512280702 0 0 kegg serum_fattyacid NA 0.212 no no no no no no Alzheimer disease PUFA+blood 0 0 -0.51 kegg serum_fattyacid NA 0.212 no no no no no no AMPK signaling pathway PUFA+blood 0 0 0.461538462 kegg serum_fattyacid NA 0.212 no no no no no no Arachidonic acid metabolism PUFA+blood 0 0 0.406923077 kegg serum_fattyacid NA 0.212 no no no no no no Bifidobacterium PUFA+blood 0 -0.657265605 0 acetate-producing Genus serum_fattyacid 0.105 0.212 no dn no no no no Biosynthesis of cofactors PUFA+blood 0 0 0.636923077 kegg serum_fattyacid NA 0.212 no no no no no no butyric acid C4+blood PUFA+blood 0.505263158 0 0 serum_scfa serum_fattyacid 0.407 0.212 no no no no no no Cardiac muscle contraction PUFA+blood 0 0 -0.515384615 kegg serum_fattyacid NA 0.212 no no up no no no DCA+blood PUFA+blood -0.515789474 0 0 serum_bileacids serum_fattyacid 0.122 0.212 no no no no no no Diabetic cardiomyopathy PUFA+blood 0 0 -0.446923077 kegg serum_fattyacid NA 0.212 no no no no no no DMG+blood PUFA+blood 0 -0.553921569 0 serum_choline serum_fattyacid 0.909 0.212 no no no no no no EPA+blood PUFA+blood 0.461654135 0 0 serum_ARA serum_fattyacid 0.212 0.212 no no no no no no GCDCA+blood PUFA+blood 0 0 -0.511111111 serum_bileacids serum_fattyacid 0.31 0.212 no no no no no no GLCA+blood PUFA+blood 0 0 -0.477393357 serum_bileacids serum_fattyacid 0.319 0.212 no no no no no no Glutathione metabolism PUFA+blood 0 0 0.561538462 kegg serum_fattyacid NA 0.212 no no no no no no "Glycine, serine and threonine metabolism" PUFA+blood 0 -0.567647059 0.595384615 kegg serum_fattyacid NA 0.212 no up no no no no GUDCA+blood PUFA+blood 0 0 -0.404444444 serum_bileacids serum_fattyacid 0.0766 0.212 no no dn no no no iso-DCA+blood PUFA+blood 0 0 0.42017094 serum_bileacids serum_fattyacid 0.38 0.212 no no no no no no isovaleric acid iso-C5+blood PUFA+blood 0 0.546568627 0 serum_scfa serum_fattyacid 0.117 0.212 no no no no no no Kaposi sarcoma-associated herpesvirus infection PUFA+blood -0.470175439 0 0 kegg serum_fattyacid NA 0.212 no no dn no no no L-Proline+blood PUFA+blood -0.469172932 0 -0.424957265 yes serum_aminoacids serum_fattyacid 0.00265 0.212 up up no no no no Lipid and atherosclerosis PUFA+blood 0.489473684 0 0 kegg serum_fattyacid NA 0.212 no no no no no no Longevity regulating pathway PUFA+blood 0 0 0.475384615 kegg serum_fattyacid NA 0.212 no no no no no no Malaria PUFA+blood 0 0 0.416153846 kegg serum_fattyacid NA 0.212 no no no no no no MicroRNAs in cancer PUFA+blood 0 0 -0.417692308 kegg serum_fattyacid NA 0.212 no no no no no no Mitophagy - animal PUFA+blood -0.470175439 0 0 kegg serum_fattyacid NA 0.212 no no no no no no MUFA+blood PUFA+blood 0.74887218 0.546568627 0.419487179 serum_fattyacid serum_fattyacid 0.00175 0.212 up no dn no no no n3+blood PUFA+blood 0 0.514705882 0 serum_fattyacid serum_fattyacid 0.806 0.212 no no no no no no n6+blood PUFA+blood 0.867669173 0.953431373 0.940512821 serum_fattyacid serum_fattyacid 0.153 0.212 no no no no no no NOD-like receptor signaling pathway PUFA+blood 0.459649123 0 0 kegg serum_fattyacid NA 0.212 no no no no no no Oxidative phosphorylation PUFA+blood 0 0 -0.430769231 kegg serum_fattyacid NA 0.212 no no no no no no Parkinson disease PUFA+blood -0.531578947 0 0 kegg serum_fattyacid NA 0.212 no no no no no no Pathways of neurodegeneration - multiple diseases PUFA+blood -0.540350877 0 0 kegg serum_fattyacid NA 0.212 no no no no no no Pertussis PUFA+blood 0.566666667 0 0 kegg serum_fattyacid NA 0.212 no no dn no no no Porphyrin and chlorophyll metabolism PUFA+blood 0 -0.588235294 0.627692308 kegg serum_fattyacid NA 0.212 no no no no no no Prevotella PUFA+blood 0 0.528252371 0 acetate-producing Genus serum_fattyacid 0.287 0.212 no no no no no no Prion disease PUFA+blood 0 0 -0.428461538 kegg serum_fattyacid NA 0.212 no no no no no no Progesterone-mediated oocyte maturation PUFA+blood 0 0 -0.407692308 kegg serum_fattyacid NA 0.212 no no no no no no Purine metabolism PUFA+blood 0 0 0.441538462 kegg serum_fattyacid NA 0.212 no no no no no no Retrograde endocannabinoid signaling PUFA+blood 0 0 -0.431538462 kegg serum_fattyacid NA 0.212 no no up no no no Ruminococcus PUFA+blood 0 -0.602941176 0 acetate-producing Genus serum_fattyacid 0.335 0.212 no no no no no no Shigellosis PUFA+blood -0.615789474 0 0 kegg serum_fattyacid NA 0.212 no no no no no no Sphingolipid signaling pathway PUFA+blood 0 0 -0.567692308 kegg serum_fattyacid NA 0.212 no no no no no no Tuberculosis PUFA+blood 0.457894737 0 0 kegg serum_fattyacid NA 0.212 no no dn no no no Ubiquitin mediated proteolysis PUFA+blood -0.507017544 0 0.408461538 kegg serum_fattyacid NA 0.212 no no no no no no Wnt signaling pathway PUFA+blood 0 0 -0.408461538 kegg serum_fattyacid NA 0.212 no no no no no no Fatty acid biosynthesis Purine metabolism 0 -0.43972332 0 kegg kegg NA NA no no no no no no Galactose metabolism Purine metabolism 0 -0.41798419 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Purine metabolism 0 0.41798419 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Purine metabolism 0 0 -0.435778636 kegg kegg NA NA no no no no no no Pentose phosphate pathway Purine metabolism 0 -0.668972332 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Purine metabolism 0 0.461462451 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Pyrimidine metabolism 0 -0.659090909 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Pyrimidine metabolism 0 0.429841897 0.423423423 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Pyrimidine metabolism 0.585217391 0.688735178 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Pyrimidine metabolism 0 -0.652173913 0 kegg kegg NA NA no no no no no no Fatty acid degradation Pyrimidine metabolism 0.631304348 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Pyrimidine metabolism 0.666956522 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Pyrimidine metabolism 0.709565217 0 0.437837838 kegg kegg NA NA no no no no no no Galactose metabolism Pyrimidine metabolism 0.729565217 0 0.487516088 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Pyrimidine metabolism 0.717391304 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Pyrimidine metabolism -0.707826087 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Pyrimidine metabolism 0 0.726284585 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Pyrimidine metabolism 0 -0.532608696 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Pyrimidine metabolism 0.688695652 0 0 kegg kegg NA NA no no no no no no Purine metabolism Pyrimidine metabolism 0 0.533596838 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Pyrimidine metabolism 0 0.614624506 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Pyrimidine metabolism 0.52 0.652173913 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Pyrimidine metabolism 0.540869565 0.707509881 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Pyrimidine metabolism 0.746086957 0.77173913 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Pyruvate metabolism 0 -0.663043478 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Pyruvate metabolism 0.442608696 -0.481225296 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Pyruvate metabolism 0.622608696 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Pyruvate metabolism 0 -0.707509881 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Pyruvate metabolism 0 -0.664031621 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Pyruvate metabolism 0.500869565 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Pyruvate metabolism 0.566956522 0.541501976 0.558558559 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Pyruvate metabolism 0.833913043 0.872529644 0.474903475 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Pyruvate metabolism 0.913913043 0.969367589 0.806949807 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Pyruvate metabolism 0 -0.671936759 0 kegg kegg NA NA no no no no no no Fatty acid degradation Pyruvate metabolism 0.413913043 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Pyruvate metabolism 0.517391304 0.600790514 0.632689833 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Pyruvate metabolism 0 -0.537549407 0 kegg kegg NA NA no no no no no no Galactose metabolism Pyruvate metabolism 0 -0.486166008 0 kegg kegg NA NA no no no no no no Glutathione metabolism Pyruvate metabolism 0 0.672924901 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Pyruvate metabolism 0 -0.433794466 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Pyruvate metabolism 0 0.456521739 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Pyruvate metabolism 0.657391304 0.81027668 0.440926641 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Pyruvate metabolism 0 -0.852766798 -0.593822394 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Pyruvate metabolism -0.468695652 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Pyruvate metabolism -0.52173913 -0.522727273 -0.401029601 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Pyruvate metabolism -0.575652174 -0.577075099 -0.403346203 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Pyruvate metabolism 0.431304348 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Pyruvate metabolism 0.520869565 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Pyruvate metabolism -0.433913043 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Pyruvate metabolism 0.610434783 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Pyruvate metabolism 0 0.713438735 0 kegg kegg NA NA no no no no no no Other glycan degradation Pyruvate metabolism 0 -0.415019763 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Pyruvate metabolism 0 0.557312253 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Pyruvate metabolism 0.740869565 0.81916996 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Pyruvate metabolism 0 -0.516798419 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Pyruvate metabolism 0.520869565 0.665019763 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Pyruvate metabolism 0.834782609 0.632411067 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Pyruvate metabolism 0.557391304 0.606719368 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Pyruvate metabolism -0.542608696 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Pyruvate metabolism 0 -0.626482213 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Pyruvate metabolism 0 0.690711462 0.523294723 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Pyruvate metabolism 0.66173913 0.618577075 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Pyruvate metabolism 0.894782609 0.727272727 0.577348777 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Pyruvate metabolism 0 -0.520750988 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Pyruvate metabolism 0.765217391 0.704545455 0.586100386 kegg kegg NA NA no up no no no no Tyrosine metabolism Pyruvate metabolism 0.771304348 0.799407115 0.681338481 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Pyruvate metabolism 0.780869565 0.662055336 0.588416988 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Pyruvate metabolism 0.87826087 0.759881423 0.711711712 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Pyruvate metabolism 0 0.591897233 0 kegg kegg NA NA no no no no no no 12-ketoDCA+blood RANTES 0 0.592268575 0 yes serum_bileacids serum_cytokines 0.517 0.0757 no no no no no up 16:1/18:2-PG+blood RANTES 0 -0.514285714 0 yes serum_phospholipids serum_cytokines 1.40E-08 0.0757 no up up no no up 18:0-LPE+blood RANTES 0 0 0.612030075 yes serum_phospholipids serum_cytokines 0.491 0.0757 no no no no no up 18:0/20:3-PI+blood RANTES 0 -0.517857143 0 yes serum_phospholipids serum_cytokines 0.377 0.0757 no no no no no up 18:3/18:2-PC+blood RANTES 0 0 0.523308271 yes serum_phospholipids serum_cytokines 0.0394 0.0757 no no up no no up 20:1+blood RANTES 0 0 -0.460150376 yes yes serum_fattyacid serum_cytokines 2.56E-05 0.0757 dn dn dn no no up 22:6n3+blood RANTES 0.709090909 0 0 yes serum_fattyacid serum_cytokines 0.792 0.0757 no no no no no up Alzheimer disease RANTES -0.604395604 0 0.517241379 yes kegg serum_cytokines NA 0.0757 no no no no no up Amyotrophic lateral sclerosis RANTES -0.686813187 0 0.487684729 yes kegg serum_cytokines NA 0.0757 no no no no no up Antigen processing and presentation RANTES 0 -0.470676692 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Arginine and proline metabolism RANTES 0 0 -0.507936508 yes kegg serum_cytokines NA 0.0757 no up no no no up Asthma RANTES 0 -0.485714286 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Bacterial invasion of epithelial cells RANTES 0 -0.484210526 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Bacteroides RANTES 0.648351648 0 0 LPS-producing yes Genus serum_cytokines 0.000267 0.0757 dn dn up no no up C-type lectin receptor signaling pathway RANTES -0.571428571 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up CA+blood RANTES 0 0 0.486377594 yes serum_bileacids serum_cytokines 0.606 0.0757 no no no no no up CA+stool RANTES 0 -0.699300699 0 yes stool_bileacids serum_cytokines 0.827 0.0757 no no no no no up Carbon metabolism RANTES 0 -0.539849624 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Cardiac muscle contraction RANTES -0.615384615 0 0.464696223 yes kegg serum_cytokines NA 0.0757 no no up no no up CDCA+stool RANTES 0 -0.622377622 0 yes stool_bileacids serum_cytokines 0.663 0.0757 no no no no no up Chemical carcinogenesis - receptor activation RANTES 0 0.530827068 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Chronic myeloid leukemia RANTES -0.576923077 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Clostridium RANTES 0 -0.456437317 0 yes Genus serum_cytokines 0.925 0.0757 no no no no no up Cysteine+blood RANTES 0 0 -0.572932331 yes yes serum_aminoacids serum_cytokines 1.81E-07 0.0757 dn up up no no up Cytosolic DNA-sensing pathway RANTES -0.571428571 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Diabetic cardiomyopathy RANTES -0.587912088 0 0.431308155 yes kegg serum_cytokines NA 0.0757 no no no no no up DPA+blood RANTES 0 0 -0.44962406 yes serum_ARA serum_cytokines 0.519 0.0757 no no no no no up Epstein-Barr virus infection RANTES 0 -0.452631579 0 yes kegg serum_cytokines NA 0.0757 no no no no no up ErbB signaling pathway RANTES 0 0.515789474 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Faecalibacterium RANTES -0.67032967 0 0 butyrate-producing yes Genus serum_cytokines 0.0039 0.0757 no dn dn no no up GCA+stool RANTES 0 -0.678321678 0 yes stool_bileacids serum_cytokines 0.0809 0.0757 no no no no no up Glycolysis / Gluconeogenesis RANTES 0 -0.494736842 0 yes kegg serum_cytokines NA 0.0757 no no no no no up GM-CSF RANTES 0 0 -0.44160178 yes yes serum_cytokines serum_cytokines 0.0124 0.0757 up no no no no up Hepatitis C RANTES -0.576923077 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Huntington disease RANTES 0 0 0.462506842 yes kegg serum_cytokines NA 0.0757 no no no no no up IFN-g RANTES -0.71978022 -0.714285714 -0.439377086 yes serum_cytokines serum_cytokines 0.825 0.0757 no no no no no up IL-13 RANTES 0 0 -0.749499444 yes yes serum_cytokines serum_cytokines 0.00264 0.0757 up up no no no up IL-17 signaling pathway RANTES 0 0 -0.425834702 yes kegg serum_cytokines NA 0.0757 no no no no no up IL-17A RANTES -0.598901099 0 0 yes serum_cytokines serum_cytokines 0.855 0.0757 no no no no no up IL-1b RANTES 0.664835165 0 -0.510567297 yes yes serum_cytokines serum_cytokines 0.00358 0.0757 up up no no no up IL-2 RANTES 0 -0.515584416 0 yes serum_cytokines serum_cytokines 0.522 0.0757 no no no no no up IL-6 RANTES 0 -0.7 0 yes serum_cytokines serum_cytokines 0.52 0.0757 no no no no no up IL-9 RANTES 0 0.794805195 0 yes serum_cytokines serum_cytokines 0.906 0.0757 no no no no no up Insulin resistance RANTES -0.56043956 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up IP-10 RANTES 0.697802198 0 0 yes serum_cytokines serum_cytokines 0.394 0.0757 no no no no no up iso-DCA+blood RANTES 0 0 -0.452631579 yes serum_bileacids serum_cytokines 0.38 0.0757 no no no no no up iso-LCA+blood RANTES 0 0.69102029 0 yes serum_bileacids serum_cytokines 0.507 0.0757 no no no no no up iso-LCA+stool RANTES 0 0.692307692 0 yes stool_bileacids serum_cytokines 0.72 0.0757 no no no no no up L-Aspartic acid+blood RANTES 0 0 -0.466165414 yes yes serum_aminoacids serum_cytokines 0.0226 0.0757 up up no no no up L-Histidine+blood RANTES 0 0 -0.6 yes serum_aminoacids serum_cytokines 0.109 0.0757 no no no no no up L-Homocystine+blood RANTES 0 0.585714286 0 yes serum_aminoacids serum_cytokines 0.197 0.0757 no no no no no up L-Isoleucine+blood RANTES 0 -0.6 -0.508270677 yes yes serum_aminoacids serum_cytokines 5.47E-06 0.0757 up up no no no up L-Leucine+blood RANTES 0 0 -0.521804511 yes yes serum_aminoacids serum_cytokines 3.22E-05 0.0757 up up no no no up L-Ornithine+blood RANTES 0 0 -0.527819549 yes serum_aminoacids serum_cytokines 0.175 0.0757 no no no no no up L-Phenylalanine+blood RANTES 0 0 -0.565413534 yes yes serum_aminoacids serum_cytokines 0.0103 0.0757 up up no no no up L-Phenylalanine+stool RANTES 0 0 -0.509803922 yes stool_cometabolism serum_cytokines 0.398 0.0757 no no no no no up L-Tryptophan+urine RANTES -0.733333333 0 0 yes urine_cometabolism serum_cytokines 0.226 0.0757 no no no no no up L-Tyrosine+blood RANTES 0 0 -0.521804511 yes yes serum_aminoacids serum_cytokines 0.00913 0.0757 up up no no no up L-Tyrosine+stool RANTES 0 0 -0.539215686 yes stool_cometabolism serum_cytokines 0.44 0.0757 no no no no no up L-Tyrosine+urine RANTES -0.757575758 0 0 yes urine_cometabolism serum_cytokines 0.45 0.0757 no no no no no up LCA+stool RANTES 0 0.671328671 0 yes stool_bileacids serum_cytokines 0.314 0.0757 no no no no no up Leishmaniasis RANTES 0 -0.535338346 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Leukocyte transendothelial migration RANTES 0 -0.54887218 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Lysosome RANTES 0 -0.445112782 -0.413245758 yes kegg serum_cytokines NA 0.0757 no no no no no up Measles RANTES 0 0 -0.407772304 yes kegg serum_cytokines NA 0.0757 no no no no no up MIP-1b RANTES 0 0.711688312 0.498553949 yes serum_cytokines serum_cytokines 0.632 0.0757 no no no no no up Neurotrophin signaling pathway RANTES -0.686813187 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Non-alcoholic fatty liver disease RANTES -0.604395604 0 0.403940887 yes kegg serum_cytokines NA 0.0757 no no no no no up Non-small cell lung cancer RANTES 0 0.566917293 0 yes kegg serum_cytokines NA 0.0757 no no no no no up nutriCA+stool RANTES 0 -0.767624669 0 yes stool_bileacids serum_cytokines 0.481 0.0757 no no no no no up Oxidative phosphorylation RANTES -0.593406593 0 0.432402846 yes kegg serum_cytokines NA 0.0757 no no no no no up p53 signaling pathway RANTES 0 0.589473684 0 yes kegg serum_cytokines NA 0.0757 no no no no no up "Parathyroid hormone synthesis, secretion and action" RANTES -0.659340659 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Parkinson disease RANTES -0.631868132 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Pathways in cancer RANTES 0 0.497744361 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Pathways of neurodegeneration - multiple diseases RANTES -0.631868132 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up PD-L1 expression and PD-1 checkpoint pathway in cancer RANTES -0.56043956 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up PDGF-bb RANTES 0 0 0.54705228 yes yes serum_cytokines serum_cytokines 0.111 0.0757 no no no no no up PI3K-Akt signaling pathway RANTES -0.741758242 0 0 yes yes kegg serum_cytokines NA 0.0757 no up up no no up Platinum drug resistance RANTES 0 0.463157895 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Prion disease RANTES -0.582417582 0 0.435686918 yes kegg serum_cytokines NA 0.0757 no no no no no up Progesterone-mediated oocyte maturation RANTES 0 0.470676692 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Propionic acid+stool RANTES 0 0 0.644607843 yes yes stool_scfa serum_cytokines 0.0436 0.0757 dn no up no no up Prostate cancer RANTES -0.675824176 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Relaxin signaling pathway RANTES -0.648351648 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Retrograde endocannabinoid signaling RANTES 0 0 0.527093596 yes kegg serum_cytokines NA 0.0757 no no up no no up Sarcosine+blood RANTES 0 0 -0.461654135 yes serum_choline serum_cytokines 5.06E-05 0.0757 up up no no no up Serine+blood RANTES 0 0 -0.520300752 yes serum_aminoacids serum_cytokines 0.942 0.0757 no no no no no up SFA%+blood RANTES 0 0 -0.497744361 yes serum_fattyacid serum_cytokines 0.0236 0.0757 no up no no no up Signaling pathways regulating pluripotency of stem cells RANTES -0.554945055 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up Spliceosome RANTES 0 0.521804511 0 yes kegg serum_cytokines NA 0.0757 no no no no no up T cell receptor signaling pathway RANTES -0.692307692 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up TCA+stool RANTES 0 -0.630473822 0 yes stool_bileacids serum_cytokines 0.458 0.0757 no no no no no up TDCA+stool RANTES 0 -0.637111543 0 yes stool_bileacids serum_cytokines 0.963 0.0757 no no no no no up Thermogenesis RANTES -0.598901099 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up TNF signaling pathway RANTES -0.631868132 0 0 yes kegg serum_cytokines NA 0.0757 no no no no no up TXB2+blood RANTES 0.747723819 0 0 yes yes serum_ARA serum_cytokines 0.0644 0.0757 dn no no no no up UDCA+stool RANTES 0 -0.615384615 0 yes stool_bileacids serum_cytokines 0.266 0.0757 no no no no no up Valine+blood RANTES 0 0 -0.559398496 yes yes serum_aminoacids serum_cytokines 1.22E-06 0.0757 up up no no no up ABC transporters Rap1 signaling pathway 0 -0.555335968 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" Rap1 signaling pathway 0 -0.444664032 0 kegg kegg NA NA no no no no no no Alistipes Rap1 signaling pathway 0 -0.484399702 0 Genus kegg 0.0114 NA no up no no no no Anaerostipes Rap1 signaling pathway 0 -0.419642491 0 butyrate-producing Genus kegg 0.568 NA no no no no no no Basal transcription factors Rap1 signaling pathway -0.77826087 0 -0.577348777 kegg kegg NA NA no no no no no no Base excision repair Rap1 signaling pathway -0.802608696 -0.425889328 -0.440926641 kegg kegg NA NA no no no no no no Butyricicoccus Rap1 signaling pathway -0.430856054 0 0 butyrate-producing Genus kegg 0.852 NA no no no no no no DNA replication Rap1 signaling pathway -0.539130435 0 -0.41003861 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Rap1 signaling pathway 0 0.424901186 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Rap1 signaling pathway -0.489565217 0 -0.418790219 kegg kegg NA NA no no no no no no Fanconi anemia pathway Rap1 signaling pathway -0.566956522 -0.46541502 -0.506821107 kegg kegg NA NA no no no no no no Fatty acid degradation Rap1 signaling pathway 0 -0.47826087 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Rap1 signaling pathway 0 -0.498023715 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Rap1 signaling pathway -0.54 -0.602766798 -0.406435006 kegg kegg NA NA no no up no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Rap1 signaling pathway 0.410434783 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Rap1 signaling pathway 0.471304348 0 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Rap1 signaling pathway -0.420869565 -0.438735178 0 kegg kegg NA NA no no no no no no Homologous recombination Rap1 signaling pathway -0.512173913 -0.668972332 -0.542084942 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Rap1 signaling pathway 0 -0.591897233 0 kegg kegg NA NA no no no no no no Lachnospira Rap1 signaling pathway 0 0.582653835 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Lysine degradation Rap1 signaling pathway -0.554782609 -0.488142292 -0.458687259 kegg kegg NA NA no no no no no no MAPK signaling pathway Rap1 signaling pathway 0 -0.719367589 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Rap1 signaling pathway 0 -0.734189723 -0.484427284 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Rap1 signaling pathway -0.426956522 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Rap1 signaling pathway -0.566956522 0 0 kegg kegg NA NA no no no no no no Oscillospira Rap1 signaling pathway 0 -0.444664032 0 LPS-producing Genus kegg 0.62 NA no no no no no no Other glycan degradation Rap1 signaling pathway 0 -0.422924901 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Rap1 signaling pathway -0.560869565 -0.510869565 -0.503732304 kegg kegg NA NA no no no no no no Oxidative phosphorylation Rap1 signaling pathway 0 0.462450593 0.419305019 kegg kegg NA NA no no no no no no Pentose phosphate pathway Rap1 signaling pathway 0.475652174 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Rap1 signaling pathway 0.417391304 0 0 kegg kegg NA NA no no no no no no Platinum drug resistance Rap1 signaling pathway -0.788695652 -0.660079051 -0.483397683 kegg kegg NA NA no no no no no no Proteasome Rap1 signaling pathway -0.448695652 0 0 kegg kegg NA NA no no no no no no Protein export Rap1 signaling pathway -0.56173913 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Rap1 signaling pathway 0 0 -0.551866152 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Rap1 signaling pathway -0.716521739 0 -0.482110682 kegg kegg NA NA no no no no no no RNA degradation Rap1 signaling pathway 0 0 -0.429086229 kegg kegg NA NA no no no no no no RNA polymerase Rap1 signaling pathway -0.753043478 0 0 kegg kegg NA NA no no no no no no RNA transport Rap1 signaling pathway -0.464347826 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Rap1 signaling pathway -0.763478261 -0.553359684 -0.525096525 kegg kegg NA NA no no no no no no Sphingolipid metabolism Rap1 signaling pathway 0.414782609 0.438735178 0 kegg kegg NA NA no no no no no no Spliceosome Rap1 signaling pathway -0.80173913 -0.730237154 -0.548262548 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Rap1 signaling pathway -0.477391304 -0.470355731 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Rap1 signaling pathway -0.526956522 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Rap1 signaling pathway 0 0 -0.491119691 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Rap1 signaling pathway -0.470434783 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Ras signaling pathway 0 0.632411067 0 yes kegg kegg NA NA no no no no up up "Alanine, aspartate and glutamate metabolism" Ras signaling pathway -0.427826087 -0.800395257 -0.520720721 yes kegg kegg NA NA no no no no up up alpha-Linolenic acid metabolism Ras signaling pathway -0.407826087 -0.519762846 0 yes kegg kegg NA NA no no no no up up Amino sugar and nucleotide sugar metabolism Ras signaling pathway -0.419130435 0 0 yes kegg kegg NA NA no no no no up up Antifolate resistance Ras signaling pathway 0 0 0.484684685 yes kegg kegg NA NA no no no no up up Arginine and proline metabolism Ras signaling pathway -0.486956522 -0.597826087 0 yes kegg kegg NA NA no up no no up up Arginine biosynthesis Ras signaling pathway -0.433913043 -0.768774704 -0.591505792 yes kegg kegg NA NA no no no no up up Basal transcription factors Ras signaling pathway 0 0 0.648133848 yes kegg kegg NA NA no no no no up up Base excision repair Ras signaling pathway 0 0 0.463320463 yes kegg kegg NA NA no no no no up up Biosynthesis of amino acids Ras signaling pathway 0 -0.518774704 -0.703989704 yes kegg kegg NA NA no no no no up up Biosynthesis of cofactors Ras signaling pathway 0 0 -0.405405405 yes kegg kegg NA NA no no no no up up Blautia Ras signaling pathway -0.422608696 0 0 acetate-producing yes Genus kegg 1.36E-05 NA up dn dn no up up Butanoate metabolism Ras signaling pathway 0 0.656126482 0 yes kegg kegg NA NA no no no no up up Carbon metabolism Ras signaling pathway 0 0 -0.521235521 yes kegg kegg NA NA no no no no up up Citrate cycle (TCA cycle) Ras signaling pathway 0 0.639328063 0 yes kegg kegg NA NA no no no no up up Cysteine and methionine metabolism Ras signaling pathway 0 0.570158103 0 yes kegg kegg NA NA no no no no up up DNA replication Ras signaling pathway 0 0.659090909 0.448391248 yes kegg kegg NA NA no no no no up up Drug metabolism - cytochrome P450 Ras signaling pathway 0 0.65513834 0 yes kegg kegg NA NA no no no no up up Drug metabolism - other enzymes Ras signaling pathway 0 0.726284585 0 yes kegg kegg NA NA no no no no up up EGFR tyrosine kinase inhibitor resistance Ras signaling pathway 0 0.458498024 0 yes kegg kegg NA NA no no no no up up ErbB signaling pathway Ras signaling pathway 0 0 0.504247104 yes kegg kegg NA NA no no no no up up Ether lipid metabolism Ras signaling pathway 0 0.458498024 0.575032175 yes kegg kegg NA NA no no no no up up Fanconi anemia pathway Ras signaling pathway 0 0 0.496010296 yes kegg kegg NA NA no no no no up up Fatty acid biosynthesis Ras signaling pathway 0 -0.752964427 -0.419305019 yes kegg kegg NA NA no no no no up up Fatty acid degradation Ras signaling pathway 0 -0.544466403 0 yes kegg kegg NA NA no no no no up up Fatty acid metabolism Ras signaling pathway 0 -0.497035573 0 yes kegg kegg NA NA no no no no up up Folate biosynthesis Ras signaling pathway 0 0.604743083 0.431917632 yes kegg kegg NA NA no no no no up up Fructose and mannose metabolism Ras signaling pathway -0.533913043 0 0 yes kegg kegg NA NA no no no no up up Galactose metabolism Ras signaling pathway -0.536521739 -0.416007905 0 yes kegg kegg NA NA no no no no up up Glutathione metabolism Ras signaling pathway 0 0.464426877 0 yes kegg kegg NA NA no no no no up up Glycerolipid metabolism Ras signaling pathway 0 0 0.457400257 yes kegg kegg NA NA no no up no up up Glycerophospholipid metabolism Ras signaling pathway 0 0 0.622651223 yes kegg kegg NA NA no no up no up up "Glycine, serine and threonine metabolism" Ras signaling pathway 0 0 -0.423680824 yes kegg kegg NA NA no up no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Ras signaling pathway 0 -0.590909091 0 yes kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Ras signaling pathway 0 0.706521739 0.48983269 yes kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate Ras signaling pathway 0 0 0.695495495 yes kegg kegg NA NA no no no no up up Glycosphingolipid biosynthesis - ganglio series Ras signaling pathway 0 0.435770751 0 yes kegg kegg NA NA no no no no up up Glycosphingolipid biosynthesis - lacto and neolacto series Ras signaling pathway 0 0 0.495238095 yes kegg kegg NA NA no no no no up up Glyoxylate and dicarboxylate metabolism Ras signaling pathway -0.47826087 -0.774703557 -0.581209781 yes kegg kegg NA NA no no no no up up Histidine metabolism Ras signaling pathway -0.552173913 0 0 yes kegg kegg NA NA no no no no up up Homologous recombination Ras signaling pathway 0 0 0.456628057 yes kegg kegg NA NA no no no no up up Inositol phosphate metabolism Ras signaling pathway 0 0 0.520720721 yes kegg kegg NA NA no no no no up up Linoleic acid metabolism Ras signaling pathway 0 0 0.574002574 yes kegg kegg NA NA no no no no up up Lysine degradation Ras signaling pathway 0 0 0.690604891 yes kegg kegg NA NA no no no no up up Mannose type O-glycan biosynthesis Ras signaling pathway 0 0 0.738481338 yes kegg kegg NA NA no no no no up up Metabolism of xenobiotics by cytochrome P450 Ras signaling pathway 0 0.656126482 0 yes kegg kegg NA NA no no no no up up Mismatch repair Ras signaling pathway 0 0.531620553 0 yes kegg kegg NA NA no no no no up up mRNA surveillance pathway Ras signaling pathway 0 0.599802372 0.716602317 yes kegg kegg NA NA no no no no up up N-Glycan biosynthesis Ras signaling pathway 0.450434783 0.777667984 0.502187902 yes kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Ras signaling pathway 0 -0.712450593 -0.43037323 yes kegg kegg NA NA no no no no up up Nitrogen metabolism Ras signaling pathway 0 -0.685770751 -0.468983269 yes kegg kegg NA NA no no no no up up Non-homologous end-joining Ras signaling pathway 0 0.447628458 0 yes kegg kegg NA NA no no no no up up Nucleotide excision repair Ras signaling pathway 0 0.57312253 0.423938224 yes kegg kegg NA NA no no no no up up One carbon pool by folate Ras signaling pathway 0 0.599802372 0 yes kegg kegg NA NA no no no no up up Oscillospira Ras signaling pathway -0.433913043 0 0 LPS-producing yes Genus kegg 0.62 NA no no no no up up Other glycan degradation Ras signaling pathway -0.433913043 0 0 yes kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis Ras signaling pathway 0 0 0.687258687 yes kegg kegg NA NA no no no no up up Oxidative phosphorylation Ras signaling pathway 0 0.52173913 0 yes kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis Ras signaling pathway 0 -0.654150198 -0.425482625 yes kegg kegg NA NA no no dn no up up Pentose and glucuronate interconversions Ras signaling pathway 0 0.72826087 0 yes kegg kegg NA NA no no no no up up Pentose phosphate pathway Ras signaling pathway 0 -0.418972332 -0.601544402 yes kegg kegg NA NA no no no no up up Phenylalanine metabolism Ras signaling pathway 0 0.590909091 0 yes kegg kegg NA NA no no no no up up Platinum drug resistance Ras signaling pathway 0 0 0.458172458 yes kegg kegg NA NA no no no no up up Porphyrin and chlorophyll metabolism Ras signaling pathway 0 0 -0.43011583 yes kegg kegg NA NA no no no no up up PPAR signaling pathway Ras signaling pathway 0 -0.671936759 -0.422651223 yes kegg kegg NA NA no no no no up up Propanoate metabolism Ras signaling pathway 0 0.493083004 0 yes kegg kegg NA NA no no no no up up Proteasome Ras signaling pathway 0 0.459486166 0 yes kegg kegg NA NA no no no no up up Protein export Ras signaling pathway 0 0.694664032 0.534620335 yes kegg kegg NA NA no no no no up up Purine metabolism Ras signaling pathway 0 0 -0.422136422 yes kegg kegg NA NA no no no no up up Pyrimidine metabolism Ras signaling pathway 0 0.684782609 0 yes kegg kegg NA NA no no no no up up Pyruvate metabolism Ras signaling pathway 0 0.555335968 0 yes kegg kegg NA NA no no no no up up Retinol metabolism Ras signaling pathway 0 0.471343874 0 yes kegg kegg NA NA no no no no up up Ribosome Ras signaling pathway 0 0.450592885 0 yes kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes Ras signaling pathway 0 0.419960474 0.580694981 yes kegg kegg NA NA no no no no up up RNA degradation Ras signaling pathway 0 0.703557312 0.678764479 yes kegg kegg NA NA no no no no up up RNA polymerase Ras signaling pathway 0 0.496047431 0.523294723 yes kegg kegg NA NA no no no no up up RNA transport Ras signaling pathway 0 0.418972332 0 yes kegg kegg NA NA no no no no up up Selenocompound metabolism Ras signaling pathway 0 0 0.465637066 yes kegg kegg NA NA no no no no up up Spliceosome Ras signaling pathway 0 0 0.512226512 yes kegg kegg NA NA no no no no up up Starch and sucrose metabolism Ras signaling pathway -0.447826087 -0.651185771 0 yes kegg kegg NA NA no no no no up up Steroid biosynthesis Ras signaling pathway 0 0 0.462805663 yes kegg kegg NA NA no no no no up up Steroid hormone biosynthesis Ras signaling pathway 0 0.448616601 0.418532819 yes kegg kegg NA NA no no no no up up Sulfur metabolism Ras signaling pathway 0 0 -0.508365508 yes kegg kegg NA NA no no no no up up Synthesis and degradation of ketone bodies Ras signaling pathway 0 0.467391304 0.41003861 yes kegg kegg NA NA no no no no up up Terpenoid backbone biosynthesis Ras signaling pathway 0 0 0.587902188 yes kegg kegg NA NA no no no no up up Thiamine metabolism Ras signaling pathway 0 0.453557312 0 yes kegg kegg NA NA no no no no up up Tryptophan metabolism Ras signaling pathway 0 0.496047431 0 yes kegg kegg NA NA no up no no up up Tyrosine metabolism Ras signaling pathway 0 0.556324111 0 yes kegg kegg NA NA no no no no up up Ubiquinone and other terpenoid-quinone biosynthesis Ras signaling pathway 0 0.556324111 0 yes kegg kegg NA NA no no no no up up "Valine, leucine and isoleucine degradation" Ras signaling pathway 0 0.617588933 0 yes kegg kegg NA NA no no no no up up Various types of N-glycan biosynthesis Ras signaling pathway 0.486086957 0.746047431 0.466924067 yes kegg kegg NA NA no no no no up up ABC transporters Regulation of actin cytoskeleton 0 -0.657114625 0 kegg kegg NA NA no up up no no no Adherens junction Regulation of actin cytoskeleton 0.70173913 0.685770751 0.628828829 kegg kegg NA NA no no no no no no Antigen processing and presentation Regulation of actin cytoskeleton 0.546956522 0.494071146 0.522265122 kegg kegg NA NA no no no no no no Apelin signaling pathway Regulation of actin cytoskeleton 0 0.500988142 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Regulation of actin cytoskeleton -0.728695652 -0.606719368 0 kegg kegg NA NA no no no no no no Autophagy - animal Regulation of actin cytoskeleton -0.617391304 -0.693675889 -0.417760618 kegg kegg NA NA no no no no no no Autophagy - other Regulation of actin cytoskeleton -0.549565217 -0.668972332 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Regulation of actin cytoskeleton 0 -0.420948617 -0.40978121 kegg kegg NA NA no no no no no no Basal transcription factors Regulation of actin cytoskeleton -0.5 0 0 kegg kegg NA NA no no no no no no Base excision repair Regulation of actin cytoskeleton -0.547826087 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Regulation of actin cytoskeleton 0 0.625494071 0.407207207 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Regulation of actin cytoskeleton 0 0.623517787 0.464350064 kegg kegg NA NA no no no no no no Butanoate metabolism Regulation of actin cytoskeleton 0 0.550395257 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Regulation of actin cytoskeleton -0.43826087 -0.498023715 -0.561389961 kegg kegg NA NA no no no no no no cAMP signaling pathway Regulation of actin cytoskeleton 0 -0.433794466 -0.403346203 yes kegg kegg NA NA no up up no no no Carbon metabolism Regulation of actin cytoskeleton 0.466086957 0.658102767 0 kegg kegg NA NA no no no no no no Circadian entrainment Regulation of actin cytoskeleton 0.425217391 0.574110672 0 kegg kegg NA NA no up up no no no Circadian rhythm Regulation of actin cytoskeleton -0.426956522 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Regulation of actin cytoskeleton 0 0.611660079 0 kegg kegg NA NA no no no no no no Clostridium Regulation of actin cytoskeleton 0 0.655091919 0 Genus kegg 0.925 NA no no no no no no Complement and coagulation cascades Regulation of actin cytoskeleton 0 0 0.479021879 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Regulation of actin cytoskeleton 0 0.599802372 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Regulation of actin cytoskeleton 0 0 0.771685972 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Regulation of actin cytoskeleton 0 -0.485177866 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Regulation of actin cytoskeleton 0.520869565 0.549407115 0.464607465 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Regulation of actin cytoskeleton 0.504347826 0.671936759 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Regulation of actin cytoskeleton 0 0.48715415 0 kegg kegg NA NA no up up no no no ErbB signaling pathway Regulation of actin cytoskeleton -0.659130435 -0.720355731 0 kegg kegg NA NA no no no no no no Fatty acid elongation Regulation of actin cytoskeleton 0 0.703557312 0.516087516 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Regulation of actin cytoskeleton 0 -0.424901186 0 kegg kegg NA NA no no no no no no Focal adhesion Regulation of actin cytoskeleton 0.743478261 0.802371542 0.715057915 kegg kegg NA NA no up up no no no FoxO signaling pathway Regulation of actin cytoskeleton 0 -0.598814229 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Regulation of actin cytoskeleton 0 -0.660079051 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Regulation of actin cytoskeleton 0 -0.418972332 0 kegg kegg NA NA no up up no no no Glutathione metabolism Regulation of actin cytoskeleton 0 0.425889328 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Regulation of actin cytoskeleton -0.422608696 -0.701581028 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Regulation of actin cytoskeleton -0.826086957 -0.670948617 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Regulation of actin cytoskeleton 0.445217391 0.747035573 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Regulation of actin cytoskeleton 0 -0.746047431 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Regulation of actin cytoskeleton 0.506956522 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Regulation of actin cytoskeleton 0.544347826 0.415019763 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Regulation of actin cytoskeleton -0.484347826 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Regulation of actin cytoskeleton -0.514782609 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Regulation of actin cytoskeleton -0.437391304 0 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Regulation of actin cytoskeleton 0 0.647233202 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Regulation of actin cytoskeleton 0 0.481225296 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Regulation of actin cytoskeleton 0.648695652 0.603754941 0.658687259 kegg kegg NA NA no no no no no no Homologous recombination Regulation of actin cytoskeleton 0 -0.453557312 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Regulation of actin cytoskeleton 0 -0.664031621 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Regulation of actin cytoskeleton 0 -0.739130435 0 kegg kegg NA NA no no no no no no Lachnospira Regulation of actin cytoskeleton 0 0.550037081 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Leukocyte transendothelial migration Regulation of actin cytoskeleton 0.737391304 0.711462451 0.601029601 kegg kegg NA NA no no no no no no Linoleic acid metabolism Regulation of actin cytoskeleton 0.552173913 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Regulation of actin cytoskeleton 0 0.577075099 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Regulation of actin cytoskeleton -0.577391304 -0.563241107 0 kegg kegg NA NA no no no no no no Lysine degradation Regulation of actin cytoskeleton -0.612173913 -0.58201581 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Regulation of actin cytoskeleton -0.495652174 -0.543478261 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Regulation of actin cytoskeleton 0.551304348 0.628458498 0.535392535 kegg kegg NA NA no no no no no no Mismatch repair Regulation of actin cytoskeleton 0 0.458498024 0.491119691 kegg kegg NA NA no no no no no no mRNA surveillance pathway Regulation of actin cytoskeleton -0.488695652 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Regulation of actin cytoskeleton 0.493043478 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Regulation of actin cytoskeleton 0.534782609 0 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Regulation of actin cytoskeleton 0 -0.501976285 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Regulation of actin cytoskeleton 0.41826087 0 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Regulation of actin cytoskeleton -0.54 -0.673913043 -0.68030888 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Regulation of actin cytoskeleton 0 -0.513833992 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Regulation of actin cytoskeleton 0 0.707509881 0.414929215 kegg kegg NA NA no no no no no no Notch signaling pathway Regulation of actin cytoskeleton -0.51826087 -0.554347826 0 kegg kegg NA NA no no no no no no Oocyte meiosis Regulation of actin cytoskeleton 0 0.726284585 0 kegg kegg NA NA no no no no no no Other glycan degradation Regulation of actin cytoskeleton 0 -0.656126482 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Regulation of actin cytoskeleton -0.693913043 -0.587944664 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Regulation of actin cytoskeleton 0 0.421936759 0.409009009 kegg kegg NA NA no no no no no no p53 signaling pathway Regulation of actin cytoskeleton -0.836521739 -0.696640316 0 kegg kegg NA NA no no no no no no Paraprevotella Regulation of actin cytoskeleton 0.547579267 0 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Regulation of actin cytoskeleton 0.546956522 0.461462451 0 kegg kegg NA NA no no no no no no Phagosome Regulation of actin cytoskeleton 0.407826087 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Regulation of actin cytoskeleton 0.539130435 0.578063241 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Regulation of actin cytoskeleton -0.473913043 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Regulation of actin cytoskeleton 0 -0.673913043 0 kegg kegg NA NA no up up no no no Phototransduction Regulation of actin cytoskeleton 0.433913043 0.880434783 0.476447876 kegg kegg NA NA no no no no no no Platelet activation Regulation of actin cytoskeleton 0.724347826 0.696640316 0.629343629 kegg kegg NA NA no no no no no no Platinum drug resistance Regulation of actin cytoskeleton -0.702608696 -0.584980237 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Regulation of actin cytoskeleton 0 0.790513834 0.415186615 kegg kegg NA NA no no no no no no Propanoate metabolism Regulation of actin cytoskeleton 0 0.627470356 0 kegg kegg NA NA no no no no no no Proteasome Regulation of actin cytoskeleton 0 0.635375494 0 kegg kegg NA NA no no no no no no Protein export Regulation of actin cytoskeleton 0 0.491106719 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Regulation of actin cytoskeleton 0 0.553359684 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Regulation of actin cytoskeleton 0.676521739 0.503952569 0.548519949 kegg kegg NA NA no no no no no no Ras signaling pathway Regulation of actin cytoskeleton 0 0.51284585 0 yes kegg kegg NA NA no up up no no no Retrograde endocannabinoid signaling Regulation of actin cytoskeleton 0 0.591897233 0.560617761 kegg kegg NA NA no no up no no no Ribosome Regulation of actin cytoskeleton 0 0.444664032 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Regulation of actin cytoskeleton -0.52 0 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Regulation of actin cytoskeleton -0.408695652 -0.666007905 -0.557528958 kegg kegg NA NA no no no no no no RNA degradation Regulation of actin cytoskeleton -0.444347826 0 0 kegg kegg NA NA no no no no no no RNA polymerase Regulation of actin cytoskeleton -0.508695652 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Regulation of actin cytoskeleton -0.767826087 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Regulation of actin cytoskeleton -0.496521739 -0.625494071 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Regulation of actin cytoskeleton 0 -0.621541502 0 kegg kegg NA NA no no no no no no Spliceosome Regulation of actin cytoskeleton -0.548695652 -0.644268775 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Regulation of actin cytoskeleton 0 0.556324111 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Regulation of actin cytoskeleton 0.425217391 0.526679842 0 kegg kegg NA NA no no no no no no Sulfur metabolism Regulation of actin cytoskeleton 0 0.433794466 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Regulation of actin cytoskeleton 0 -0.611660079 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Regulation of actin cytoskeleton -0.696521739 -0.803359684 -0.480823681 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Regulation of actin cytoskeleton 0 0.656126482 0 kegg kegg NA NA no no no no no no Thermogenesis Regulation of actin cytoskeleton 0 0.422924901 0.474646075 kegg kegg NA NA no no no no no no Thiamine metabolism Regulation of actin cytoskeleton 0 0.46541502 0 kegg kegg NA NA no no no no no no Tight junction Regulation of actin cytoskeleton 0.676521739 0.781620553 0.668211068 kegg kegg NA NA no no no no no no TNF signaling pathway Regulation of actin cytoskeleton 0 -0.674901186 -0.424195624 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Regulation of actin cytoskeleton 0 -0.492094862 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Regulation of actin cytoskeleton 0 0.687747036 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Regulation of actin cytoskeleton 0 0.565217391 0.513513514 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Regulation of actin cytoskeleton 0 0.437747036 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Regulation of actin cytoskeleton 0 0.519762846 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Regulation of actin cytoskeleton 0 -0.48715415 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Regulation of actin cytoskeleton 0 0.423913043 0.701673102 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Regulation of lipolysis in adipocytes 0 0 -0.512998713 kegg kegg NA NA no no no no no no ABC transporters Regulation of lipolysis in adipocytes -0.617391304 0 0 kegg kegg NA NA no up up no no no Adipocytokine signaling pathway Regulation of lipolysis in adipocytes 0 0 0.422908623 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Regulation of lipolysis in adipocytes 0.735652174 0.557312253 0.567310167 kegg kegg NA NA no no up no no no alpha-Linolenic acid metabolism Regulation of lipolysis in adipocytes -0.48 0 -0.544401544 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Regulation of lipolysis in adipocytes 0 0 -0.44967825 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Regulation of lipolysis in adipocytes -0.447826087 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Regulation of lipolysis in adipocytes 0.434782609 0.460474308 0.533333333 kegg kegg NA NA no no no no no no Antigen processing and presentation Regulation of lipolysis in adipocytes 0 -0.429841897 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Regulation of lipolysis in adipocytes 0 0.541501976 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Regulation of lipolysis in adipocytes -0.415652174 0 0 kegg kegg NA NA no up no no no no Ascorbate and aldarate metabolism Regulation of lipolysis in adipocytes 0 0 -0.610553411 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Regulation of lipolysis in adipocytes -0.475652174 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Regulation of lipolysis in adipocytes 0 -0.440711462 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Regulation of lipolysis in adipocytes 0 0 0.435778636 kegg kegg NA NA no no no no no no Butanoate metabolism Regulation of lipolysis in adipocytes -0.415652174 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Regulation of lipolysis in adipocytes 0.554782609 0.664031621 0.533075933 kegg kegg NA NA no up up no no no cAMP signaling pathway Regulation of lipolysis in adipocytes 0.486086957 0 0.551093951 yes kegg kegg NA NA no up up no no no Carbon metabolism Regulation of lipolysis in adipocytes 0 -0.609683794 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Regulation of lipolysis in adipocytes 0 -0.52173913 0 kegg kegg NA NA no no no no no no Circadian entrainment Regulation of lipolysis in adipocytes 0.745217391 0.549407115 0.783783784 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Regulation of lipolysis in adipocytes 0 0 -0.529214929 kegg kegg NA NA no no no no no no Clostridium Regulation of lipolysis in adipocytes 0 -0.478838573 0 Genus kegg 0.925 NA no no no no no no Dopaminergic synapse Regulation of lipolysis in adipocytes 0.702608696 0.666007905 0.618018018 kegg kegg NA NA no up no no no no Drug metabolism - other enzymes Regulation of lipolysis in adipocytes 0 0 -0.653539254 kegg kegg NA NA no no no no no no Endocrine resistance Regulation of lipolysis in adipocytes 0.785217391 0.799407115 0.815186615 kegg kegg NA NA no no no no no no Endocytosis Regulation of lipolysis in adipocytes 0 -0.443675889 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Regulation of lipolysis in adipocytes 0 0 0.570656371 kegg kegg NA NA no no no no no no Fatty acid degradation Regulation of lipolysis in adipocytes -0.449565217 -0.437747036 -0.575289575 kegg kegg NA NA no no no no no no Fatty acid elongation Regulation of lipolysis in adipocytes 0 -0.427865613 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Regulation of lipolysis in adipocytes -0.532173913 -0.431818182 -0.455341055 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Regulation of lipolysis in adipocytes -0.406956522 -0.489130435 0 kegg kegg NA NA no no no no no no Ferroptosis Regulation of lipolysis in adipocytes 0.58173913 0.541501976 0 kegg kegg NA NA no no no no no no Folate biosynthesis Regulation of lipolysis in adipocytes -0.406086957 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Regulation of lipolysis in adipocytes 0 0 -0.512483912 kegg kegg NA NA no no no no no no Galactose metabolism Regulation of lipolysis in adipocytes -0.52173913 0 -0.666409266 kegg kegg NA NA no no no no no no Gap junction Regulation of lipolysis in adipocytes 0.828695652 0.87944664 0.857400257 kegg kegg NA NA no no no no no no Glucagon signaling pathway Regulation of lipolysis in adipocytes 0.680869565 0.557312253 0.455341055 kegg kegg NA NA no no no no no no Glutamatergic synapse Regulation of lipolysis in adipocytes 0.757391304 0.632411067 0.738738739 kegg kegg NA NA no up up no no no Glutathione metabolism Regulation of lipolysis in adipocytes 0 0.472332016 0.411840412 kegg kegg NA NA no no no no no no Glycerolipid metabolism Regulation of lipolysis in adipocytes -0.547826087 0 -0.517889318 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Regulation of lipolysis in adipocytes 0 0 -0.437580438 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Regulation of lipolysis in adipocytes 0 0 0.446589447 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Regulation of lipolysis in adipocytes 0 0 -0.535135135 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Regulation of lipolysis in adipocytes 0.411304348 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Regulation of lipolysis in adipocytes 0 -0.449604743 -0.6998713 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Regulation of lipolysis in adipocytes -0.497391304 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Regulation of lipolysis in adipocytes 0.774782609 0.766798419 0.755469755 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Regulation of lipolysis in adipocytes 0 -0.504940711 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Regulation of lipolysis in adipocytes -0.47826087 0 -0.538996139 kegg kegg NA NA no no no no no no Histidine metabolism Regulation of lipolysis in adipocytes -0.503478261 0 -0.532818533 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Regulation of lipolysis in adipocytes 0.806956522 0.566205534 0.743114543 kegg kegg NA NA no no no no no no Insulin secretion Regulation of lipolysis in adipocytes 0.690434783 0.798418972 0.765765766 yes kegg kegg NA NA no up up no no no Long-term depression Regulation of lipolysis in adipocytes 0.826086957 0.801383399 0.893693694 kegg kegg NA NA no no no no no no Longevity regulating pathway Regulation of lipolysis in adipocytes 0.492173913 0 0.457142857 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Regulation of lipolysis in adipocytes 0 -0.618577075 0 kegg kegg NA NA no no no no no no Lysosome Regulation of lipolysis in adipocytes 0 -0.43972332 0 kegg kegg NA NA no no no no no no Melanogenesis Regulation of lipolysis in adipocytes 0.733913043 0.592885375 0.771171171 kegg kegg NA NA no no no no no no Mitophagy - animal Regulation of lipolysis in adipocytes 0.544347826 0.467391304 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Regulation of lipolysis in adipocytes 0 -0.449604743 0 kegg kegg NA NA no no no no no no Necroptosis Regulation of lipolysis in adipocytes 0.65826087 0.565217391 0.426512227 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Regulation of lipolysis in adipocytes 0 -0.536561265 0 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Regulation of lipolysis in adipocytes -0.577391304 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Regulation of lipolysis in adipocytes -0.473913043 -0.43083004 0 kegg kegg NA NA no no no no no no Notch signaling pathway Regulation of lipolysis in adipocytes 0 0 -0.472586873 kegg kegg NA NA no no no no no no Odoribacter Regulation of lipolysis in adipocytes 0 -0.611195534 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Osteoclast differentiation Regulation of lipolysis in adipocytes -0.48 -0.456521739 0 kegg kegg NA NA no no no no no no Other glycan degradation Regulation of lipolysis in adipocytes -0.583478261 0 -0.493693694 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Regulation of lipolysis in adipocytes 0.797391304 0.931818182 0.90990991 kegg kegg NA NA no up up no no no Peroxisome Regulation of lipolysis in adipocytes -0.506086957 -0.486166008 0 kegg kegg NA NA no no no no no no Phagosome Regulation of lipolysis in adipocytes 0 -0.432806324 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Regulation of lipolysis in adipocytes 0 0 0.417245817 kegg kegg NA NA no no no no no no PPAR signaling pathway Regulation of lipolysis in adipocytes 0 -0.473320158 0 kegg kegg NA NA no no no no no no Prevotella Regulation of lipolysis in adipocytes 0 0 0.478384292 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Regulation of lipolysis in adipocytes 0 -0.459486166 0 kegg kegg NA NA no no no no no no Proteasome Regulation of lipolysis in adipocytes 0 -0.429841897 -0.616988417 kegg kegg NA NA no no no no no no Pyrimidine metabolism Regulation of lipolysis in adipocytes -0.434782609 0 -0.415958816 kegg kegg NA NA no no no no no no Renin-angiotensin system Regulation of lipolysis in adipocytes 0 -0.437747036 0 kegg kegg NA NA no no no no no no Retinol metabolism Regulation of lipolysis in adipocytes 0 0 -0.524581725 kegg kegg NA NA no no no no no no Serotonergic synapse Regulation of lipolysis in adipocytes 0.629565217 0.709486166 0.64041184 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Regulation of lipolysis in adipocytes -0.732173913 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Regulation of lipolysis in adipocytes 0 0 -0.526898327 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Regulation of lipolysis in adipocytes -0.433043478 0 -0.640669241 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Regulation of lipolysis in adipocytes 0 0 -0.575032175 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Regulation of lipolysis in adipocytes 0 0 -0.5001287 kegg kegg NA NA no up up no no no Taste transduction Regulation of lipolysis in adipocytes 0 0 -0.401801802 kegg kegg NA NA no no up no no no Th1 and Th2 cell differentiation Regulation of lipolysis in adipocytes -0.439130435 -0.535573123 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Regulation of lipolysis in adipocytes -0.443478261 -0.606719368 0 kegg kegg NA NA no no no no no no Thiamine metabolism Regulation of lipolysis in adipocytes -0.420869565 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Regulation of lipolysis in adipocytes 0.622608696 0.851778656 0.69034749 kegg kegg NA NA no no no no no no Tryptophan metabolism Regulation of lipolysis in adipocytes -0.432173913 -0.416996047 -0.488545689 kegg kegg NA NA no up no no no no Ubiquinone and other terpenoid-quinone biosynthesis Regulation of lipolysis in adipocytes -0.45826087 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Regulation of lipolysis in adipocytes 0.517391304 0.464426877 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Regulation of lipolysis in adipocytes -0.427826087 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Regulation of lipolysis in adipocytes 0.645217391 0.464426877 0.626254826 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Relaxin signaling pathway -0.609565217 -0.577075099 -0.648906049 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Relaxin signaling pathway 0.645217391 0.765810277 0.585070785 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Relaxin signaling pathway 0.596521739 0 0.423680824 kegg kegg NA NA no no up no no no Aldosterone synthesis and secretion Relaxin signaling pathway 0.436521739 0 0.511454311 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Relaxin signaling pathway -0.546956522 0 -0.63037323 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Relaxin signaling pathway -0.54173913 0 -0.47979408 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Relaxin signaling pathway -0.59826087 -0.588932806 -0.469498069 kegg kegg NA NA no no no no no no Apelin signaling pathway Relaxin signaling pathway 0 -0.504940711 0 kegg kegg NA NA no no no no no no Apoptosis Relaxin signaling pathway 0 0.640316206 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Relaxin signaling pathway 0 0.46541502 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Relaxin signaling pathway 0 0.427865613 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Relaxin signaling pathway -0.52173913 0 -0.52972973 kegg kegg NA NA no no no no no no Autophagy - animal Relaxin signaling pathway 0 0.557312253 0 kegg kegg NA NA no no no no no no Autophagy - other Relaxin signaling pathway 0.42 0 0 kegg kegg NA NA no no no no no no Axon guidance Relaxin signaling pathway 0.523478261 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Relaxin signaling pathway 0 0.693675889 0.637837838 kegg kegg NA NA no no no no no no Bacteroides Relaxin signaling pathway 0 -0.496047431 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Relaxin signaling pathway 0 -0.502964427 0 kegg kegg NA NA no no no no no no Base excision repair Relaxin signaling pathway 0 -0.492094862 -0.543371943 kegg kegg NA NA no no no no no no beta-Alanine metabolism Relaxin signaling pathway -0.808695652 -0.718379447 -0.763191763 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Relaxin signaling pathway -0.533043478 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Relaxin signaling pathway 0 -0.466403162 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Relaxin signaling pathway -0.763478261 -0.717391304 -0.743886744 kegg kegg NA NA no no no no no no Butanoate metabolism Relaxin signaling pathway -0.706956522 -0.806324111 -0.685199485 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Relaxin signaling pathway 0.535652174 0.639328063 0.566795367 kegg kegg NA NA no no no no no no Calcium signaling pathway Relaxin signaling pathway 0.533913043 0 0.564478764 kegg kegg NA NA no up up no no no cAMP signaling pathway Relaxin signaling pathway 0.789565217 0.928853755 0.891119691 yes kegg kegg NA NA no up up no no no Carbon metabolism Relaxin signaling pathway -0.651304348 -0.503952569 -0.428314028 kegg kegg NA NA no no no no no no Cardiac muscle contraction Relaxin signaling pathway 0.520869565 0 0 kegg kegg NA NA no no up no no no Cell cycle Relaxin signaling pathway 0 -0.508893281 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Relaxin signaling pathway 0.465217391 0.562252964 0.409009009 kegg kegg NA NA no no no no no no Cholinergic synapse Relaxin signaling pathway 0.446086957 0 0 kegg kegg NA NA no no no no no no Circadian entrainment Relaxin signaling pathway 0 0 0.408494208 kegg kegg NA NA no up up no no no Circadian rhythm Relaxin signaling pathway 0.596521739 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Relaxin signaling pathway -0.755652174 -0.833003953 -0.707078507 kegg kegg NA NA no no no no no no Clostridium Relaxin signaling pathway 0 -0.536910485 0 Genus kegg 0.925 NA no no no no no no Cysteine and methionine metabolism Relaxin signaling pathway -0.454782609 -0.842885375 -0.497812098 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Relaxin signaling pathway 0.591304348 0.739130435 0.586872587 kegg kegg NA NA no no no no no no DNA replication Relaxin signaling pathway -0.483478261 -0.777667984 -0.502702703 kegg kegg NA NA no no no no no no Dopaminergic synapse Relaxin signaling pathway 0.647826087 0 0.544916345 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Relaxin signaling pathway 0 -0.733201581 -0.421621622 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Relaxin signaling pathway -0.706086957 -0.643280632 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Relaxin signaling pathway 0 -0.506916996 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Relaxin signaling pathway 0 -0.416996047 0 kegg kegg NA NA no no no no no no Endocrine resistance Relaxin signaling pathway 0.437391304 0 0.55958816 kegg kegg NA NA no no no no no no ErbB signaling pathway Relaxin signaling pathway 0.451304348 0.449604743 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Relaxin signaling pathway 0 -0.647233202 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Relaxin signaling pathway 0.432173913 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Relaxin signaling pathway 0 -0.499011858 -0.517117117 kegg kegg NA NA no no no no no no Fatty acid degradation Relaxin signaling pathway -0.634782609 0 -0.670527671 kegg kegg NA NA no no no no no no Fatty acid elongation Relaxin signaling pathway -0.82 -0.733201581 -0.726126126 kegg kegg NA NA no no no no no no Fatty acid metabolism Relaxin signaling pathway -0.70173913 0 -0.659459459 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Relaxin signaling pathway 0 0.575098814 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Relaxin signaling pathway -0.552173913 0 0 kegg kegg NA NA no no no no no no Ferroptosis Relaxin signaling pathway 0.422608696 0.624505929 0.428571429 kegg kegg NA NA no no no no no no Focal adhesion Relaxin signaling pathway 0 -0.440711462 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Relaxin signaling pathway 0 0 -0.484427284 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Relaxin signaling pathway -0.414782609 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Relaxin signaling pathway -0.588695652 0 0 kegg kegg NA NA no no no no no no Gap junction Relaxin signaling pathway 0 0.60770751 0.412355212 kegg kegg NA NA no no no no no no Glutamatergic synapse Relaxin signaling pathway 0 0.583003953 0.439124839 kegg kegg NA NA no up up no no no Glycolysis / Gluconeogenesis Relaxin signaling pathway -0.643478261 -0.713438735 -0.566537967 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Relaxin signaling pathway 0 0.647233202 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Relaxin signaling pathway -0.476521739 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Relaxin signaling pathway 0.435652174 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Relaxin signaling pathway 0 -0.5 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Relaxin signaling pathway 0 0.529644269 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Relaxin signaling pathway 0.48 0 0.611325611 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Relaxin signaling pathway 0 -0.416996047 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Relaxin signaling pathway -0.616521739 -0.658102767 -0.531274131 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Relaxin signaling pathway 0 -0.511857708 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Relaxin signaling pathway 0 -0.416996047 0 kegg kegg NA NA no no no no no no Histidine metabolism Relaxin signaling pathway -0.674782609 0 -0.658172458 kegg kegg NA NA no no no no no no Homologous recombination Relaxin signaling pathway 0 0 -0.496782497 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Relaxin signaling pathway 0 0 -0.415444015 kegg kegg NA NA no no no no no no Insulin secretion Relaxin signaling pathway 0.42173913 0 0.747490347 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Relaxin signaling pathway 0 -0.529644269 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Relaxin signaling pathway 0 0.446640316 0 kegg kegg NA NA no no no no no no Long-term depression Relaxin signaling pathway 0.511304348 0.723320158 0.66975547 kegg kegg NA NA no no no no no no Long-term potentiation Relaxin signaling pathway 0 -0.768774704 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Relaxin signaling pathway 0.515652174 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Relaxin signaling pathway -0.553913043 -0.636363636 -0.669498069 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Relaxin signaling pathway 0.507826087 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Relaxin signaling pathway -0.49826087 -0.751976285 -0.455083655 kegg kegg NA NA no no no no no no Mismatch repair Relaxin signaling pathway -0.642608696 -0.849802372 -0.54028314 kegg kegg NA NA no no no no no no Mitophagy - animal Relaxin signaling pathway 0.668695652 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Relaxin signaling pathway 0.529565217 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Relaxin signaling pathway 0 -0.423913043 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Relaxin signaling pathway 0 0 -0.43037323 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Relaxin signaling pathway 0 -0.533596838 0 kegg kegg NA NA no no no no no no Necroptosis Relaxin signaling pathway 0.453043478 0.544466403 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Relaxin signaling pathway 0.74173913 0.68972332 0.631402831 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Relaxin signaling pathway 0 0.67687747 0.487516088 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Relaxin signaling pathway 0 0.429841897 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Relaxin signaling pathway 0 0.492094862 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Relaxin signaling pathway 0 0.438735178 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Relaxin signaling pathway -0.793913043 -0.875494071 -0.661776062 kegg kegg NA NA no no no no no no Notch signaling pathway Relaxin signaling pathway 0 0.515810277 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Relaxin signaling pathway -0.535652174 -0.755928854 -0.568854569 kegg kegg NA NA no no no no no no One carbon pool by folate Relaxin signaling pathway -0.528695652 -0.691699605 -0.49009009 kegg kegg NA NA no no no no no no Oocyte meiosis Relaxin signaling pathway 0 -0.821146245 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Relaxin signaling pathway 0 0 0.504761905 kegg kegg NA NA no up up no no no Oxidative phosphorylation Relaxin signaling pathway 0.47826087 0 0 kegg kegg NA NA no no no no no no Paraprevotella Relaxin signaling pathway -0.447092647 0 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Relaxin signaling pathway -0.553043478 -0.694664032 -0.488803089 kegg kegg NA NA no no no no no no Peroxisome Relaxin signaling pathway -0.539130435 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Relaxin signaling pathway -0.617391304 -0.688735178 -0.479021879 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Relaxin signaling pathway 0 -0.454545455 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Relaxin signaling pathway 0 0.781620553 0.546975547 kegg kegg NA NA no up up no no no Phototransduction Relaxin signaling pathway 0 -0.678853755 0 kegg kegg NA NA no no no no no no Platinum drug resistance Relaxin signaling pathway 0 0 -0.4002574 kegg kegg NA NA no no no no no no PPAR signaling pathway Relaxin signaling pathway 0 0.420948617 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Relaxin signaling pathway -0.769565217 -0.778656126 -0.552895753 kegg kegg NA NA no no no no no no Prolactin signaling pathway Relaxin signaling pathway 0.432173913 0.557312253 0 kegg kegg NA NA no no no no no no Propanoate metabolism Relaxin signaling pathway -0.576521739 -0.835968379 -0.487258687 kegg kegg NA NA no no no no no no Proteasome Relaxin signaling pathway 0 -0.751976285 0 kegg kegg NA NA no no no no no no Protein export Relaxin signaling pathway 0 -0.530632411 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Relaxin signaling pathway 0 -0.448616601 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Relaxin signaling pathway -0.699130435 -0.62944664 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Relaxin signaling pathway -0.649565217 -0.78458498 -0.51042471 kegg kegg NA NA no no no no no no Ras signaling pathway Relaxin signaling pathway 0 -0.489130435 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Relaxin signaling pathway 0 -0.57312253 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Relaxin signaling pathway 0.422608696 0 0.517117117 kegg kegg NA NA no no no no no no Retinol metabolism Relaxin signaling pathway -0.726956522 -0.670948617 -0.707335907 kegg kegg NA NA no no no no no no Ribosome Relaxin signaling pathway 0.520869565 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Relaxin signaling pathway 0 -0.570158103 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Relaxin signaling pathway 0.453913043 0.65513834 0.638352638 kegg kegg NA NA no no no no no no RNA degradation Relaxin signaling pathway 0.45826087 0 0 kegg kegg NA NA no no no no no no RNA polymerase Relaxin signaling pathway 0 -0.519762846 -0.444272844 kegg kegg NA NA no no no no no no RNA transport Relaxin signaling pathway 0 -0.446640316 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Relaxin signaling pathway 0 0 -0.512741313 kegg kegg NA NA no no no no no no Serotonergic synapse Relaxin signaling pathway 0 0.432806324 0.545431145 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Relaxin signaling pathway 0.546956522 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Relaxin signaling pathway 0.426956522 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Relaxin signaling pathway 0 -0.82312253 -0.68030888 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Relaxin signaling pathway -0.648695652 -0.716403162 -0.514543115 kegg kegg NA NA no no no no no no Sulfur metabolism Relaxin signaling pathway 0 -0.450592885 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Relaxin signaling pathway -0.606086957 -0.802371542 -0.622136422 kegg kegg NA NA no no no no no no Taste transduction Relaxin signaling pathway 0 -0.610671937 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Relaxin signaling pathway 0 0.485177866 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Relaxin signaling pathway 0 -0.670948617 -0.492664093 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Relaxin signaling pathway 0 -0.497035573 0 kegg kegg NA NA no no no no no no Thermogenesis Relaxin signaling pathway 0.48173913 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Relaxin signaling pathway 0 -0.587944664 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Relaxin signaling pathway 0 0 0.509137709 kegg kegg NA NA no no no no no no TNF signaling pathway Relaxin signaling pathway 0.820869565 0.788537549 0.681081081 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Relaxin signaling pathway 0.526956522 0.66798419 0.581981982 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Relaxin signaling pathway -0.840869565 -0.881422925 -0.711196911 kegg kegg NA NA no up no no no no Tyrosine metabolism Relaxin signaling pathway -0.725217391 -0.78458498 -0.71016731 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Relaxin signaling pathway -0.706956522 -0.77173913 -0.52020592 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Relaxin signaling pathway 0.616521739 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Relaxin signaling pathway -0.752173913 -0.773715415 -0.785585586 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Relaxin signaling pathway 0 -0.509881423 -0.45045045 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Relaxin signaling pathway 0.509565217 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Relaxin signaling pathway 0.412173913 0.513833992 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Renal cell carcinoma -0.475652174 0 0 kegg kegg NA NA no no no no no no ABC transporters Renal cell carcinoma -0.459130435 0 0 kegg kegg NA NA no up up no no no Adherens junction Renal cell carcinoma 0 0 -0.458172458 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Renal cell carcinoma 0.651304348 0 0 kegg kegg NA NA no no up no no no Alcoholism Renal cell carcinoma 0.514782609 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Renal cell carcinoma 0.675652174 0.51284585 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Renal cell carcinoma -0.544347826 -0.602766798 0 kegg kegg NA NA no no no no no no Alzheimer disease Renal cell carcinoma 0.548695652 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Renal cell carcinoma -0.691304348 -0.610671937 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Renal cell carcinoma -0.552173913 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Renal cell carcinoma 0.526956522 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Renal cell carcinoma -0.58173913 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Renal cell carcinoma 0 0.41798419 0 kegg kegg NA NA no no no no no no Apoptosis Renal cell carcinoma 0 0 -0.448133848 kegg kegg NA NA no no no no no no Apoptosis - multiple species Renal cell carcinoma 0 0 0.44967825 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Renal cell carcinoma -0.445217391 0 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Renal cell carcinoma -0.516521739 0 0 kegg kegg NA NA no no no no no no Autophagy - animal Renal cell carcinoma 0 0 0.431660232 kegg kegg NA NA no no no no no no Autophagy - other Renal cell carcinoma 0.484347826 0 0.488803089 kegg kegg NA NA no no no no no no Axon guidance Renal cell carcinoma 0.832173913 0.674901186 0.534362934 kegg kegg NA NA no up up no no no beta-Alanine metabolism Renal cell carcinoma -0.685217391 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Renal cell carcinoma -0.469565217 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Renal cell carcinoma -0.426086957 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Renal cell carcinoma -0.563478261 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Renal cell carcinoma -0.532173913 0 0 kegg kegg NA NA no no no no no no Butyricimonas Renal cell carcinoma 0.41330708 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no C-type lectin receptor signaling pathway Renal cell carcinoma 0.466086957 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Renal cell carcinoma 0.693913043 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Renal cell carcinoma 0.674782609 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Renal cell carcinoma 0.410434783 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Renal cell carcinoma -0.50173913 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Renal cell carcinoma 0.519130435 0 0 kegg kegg NA NA no no up no no no Chagas disease Renal cell carcinoma 0.455652174 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Renal cell carcinoma -0.520869565 0 -0.457915058 kegg kegg NA NA no no no no no no Chemokine signaling pathway Renal cell carcinoma 0.42173913 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Renal cell carcinoma 0.72173913 0 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Renal cell carcinoma 0 -0.456521739 0 kegg kegg NA NA no no no no no no Colorectal cancer Renal cell carcinoma 0.648695652 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Renal cell carcinoma 0.49826087 0 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Renal cell carcinoma 0 0.435770751 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Renal cell carcinoma 0.445217391 0 0 kegg kegg NA NA no up no no no no Drug metabolism - other enzymes Renal cell carcinoma -0.48173913 0 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Renal cell carcinoma 0 0 0.446589447 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Renal cell carcinoma 0 0.497035573 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Renal cell carcinoma 0 0.414031621 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Renal cell carcinoma 0.566086957 0 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Renal cell carcinoma -0.577391304 -0.432806324 0 yes kegg kegg NA NA no up up no no no Fatty acid degradation Renal cell carcinoma -0.540869565 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Renal cell carcinoma -0.482608696 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Renal cell carcinoma -0.622608696 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Renal cell carcinoma -0.686086957 -0.414031621 0 kegg kegg NA NA no no no no no no Galactose metabolism Renal cell carcinoma -0.746086957 -0.498023715 0 kegg kegg NA NA no no no no no no Gastric acid secretion Renal cell carcinoma 0 0 -0.505019305 kegg kegg NA NA no no no no no no Glucagon signaling pathway Renal cell carcinoma 0 0 0.405148005 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Renal cell carcinoma 0 -0.414031621 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Renal cell carcinoma -0.58173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Renal cell carcinoma 0.600869565 0.414031621 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Renal cell carcinoma 0.476521739 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Renal cell carcinoma -0.442608696 0 0 kegg kegg NA NA no no no no no no GnRH secretion Renal cell carcinoma 0.526086957 0 0 kegg kegg NA NA no up up no no no Hedgehog signaling pathway Renal cell carcinoma 0.445217391 0 0 kegg kegg NA NA no no no no no no Hepatitis C Renal cell carcinoma 0.457391304 0.438735178 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Renal cell carcinoma 0 0.41798419 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Renal cell carcinoma 0 0.475296443 0 kegg kegg NA NA no no no no no no Histidine metabolism Renal cell carcinoma -0.715652174 -0.57312253 0 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Renal cell carcinoma 0 0.446640316 0 kegg kegg NA NA no no dn no no no Human immunodeficiency virus 1 infection Renal cell carcinoma 0 0.446640316 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Renal cell carcinoma 0 0.459486166 0 kegg kegg NA NA no no no no no no Huntington disease Renal cell carcinoma 0.513913043 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Renal cell carcinoma 0.499130435 0 0 kegg kegg NA NA no no no no no no Influenza A Renal cell carcinoma 0 0 -0.609266409 kegg kegg NA NA no no no no no no Insulin resistance Renal cell carcinoma 0.406956522 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Renal cell carcinoma 0 0.480237154 0 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Renal cell carcinoma 0.466086957 0 0 kegg kegg NA NA no no dn no no no Legionellosis Renal cell carcinoma 0 0.5 0 kegg kegg NA NA no no no no no no Leishmaniasis Renal cell carcinoma 0 0.420948617 0 kegg kegg NA NA no no no no no no Long-term potentiation Renal cell carcinoma 0.509565217 0 0.457142857 kegg kegg NA NA no no up no no no Mannose type O-glycan biosynthesis Renal cell carcinoma 0.544347826 0 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Renal cell carcinoma 0 -0.432806324 0 kegg kegg NA NA no up no no no no Mismatch repair Renal cell carcinoma -0.442608696 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Renal cell carcinoma 0.575652174 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Renal cell carcinoma 0 0.515810277 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Renal cell carcinoma 0 0 0.412612613 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Renal cell carcinoma 0.754782609 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Renal cell carcinoma 0.572173913 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Renal cell carcinoma -0.534782609 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Renal cell carcinoma 0.49826087 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Renal cell carcinoma 0.439130435 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Renal cell carcinoma 0.450434783 0 0 kegg kegg NA NA no no no no no no Parkinson disease Renal cell carcinoma 0.543478261 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Renal cell carcinoma 0.466956522 0 0.405920206 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Renal cell carcinoma 0.523478261 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Renal cell carcinoma -0.525217391 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Renal cell carcinoma 0.56173913 0 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Renal cell carcinoma 0 0.638339921 0.418532819 yes kegg kegg NA NA no up up no no no Platinum drug resistance Renal cell carcinoma 0 0 0.459459459 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Renal cell carcinoma -0.509565217 0 0 kegg kegg NA NA no no no no no no Prion disease Renal cell carcinoma 0.470434783 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Renal cell carcinoma -0.42 0 0 kegg kegg NA NA no no no no no no Proteasome Renal cell carcinoma 0.405217391 0 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Renal cell carcinoma -0.47826087 0 0 yes kegg kegg NA NA no up up no no no Protein export Renal cell carcinoma 0.414782609 0.429841897 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Renal cell carcinoma 0 0.550395257 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Renal cell carcinoma -0.612173913 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Renal cell carcinoma -0.446956522 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Renal cell carcinoma 0 0 -0.467953668 kegg kegg NA NA no no no no no no Ras signaling pathway Renal cell carcinoma 0.753043478 0 0 yes kegg kegg NA NA no up up no no no Relaxin signaling pathway Renal cell carcinoma 0.540869565 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Renal cell carcinoma -0.535652174 -0.428853755 0 kegg kegg NA NA no no no no no no Ribosome Renal cell carcinoma 0.497391304 0 0 kegg kegg NA NA no no no no no no RNA degradation Renal cell carcinoma 0.65826087 0 0 kegg kegg NA NA no no no no no no RNA transport Renal cell carcinoma 0 0.495059289 0.488288288 kegg kegg NA NA no no no no no no Shigellosis Renal cell carcinoma 0.442608696 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Renal cell carcinoma 0.630434783 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Renal cell carcinoma 0 0 -0.453281853 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Renal cell carcinoma 0.71826087 0.571146245 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Renal cell carcinoma 0.632173913 0 0 kegg kegg NA NA no no no no no no Spliceosome Renal cell carcinoma 0 0 0.411840412 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Renal cell carcinoma -0.539130435 -0.495059289 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Renal cell carcinoma -0.505217391 -0.469367589 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Renal cell carcinoma 0 0 -0.415444015 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Renal cell carcinoma -0.447826087 0 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Renal cell carcinoma 0 0 0.525353925 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Renal cell carcinoma 0.60173913 0.416007905 0 kegg kegg NA NA no no no no no no Thermogenesis Renal cell carcinoma 0.467826087 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Renal cell carcinoma 0 0 -0.475160875 kegg kegg NA NA no no no no no no TNF signaling pathway Renal cell carcinoma 0.51826087 0 0 kegg kegg NA NA no no no no no no Toxoplasmosis Renal cell carcinoma -0.507826087 0 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Renal cell carcinoma -0.6 0 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Renal cell carcinoma 0.452173913 0 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Renal cell carcinoma -0.593043478 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Renal cell carcinoma -0.626086957 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Renal cell carcinoma -0.557391304 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Renal cell carcinoma 0.557391304 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Renal cell carcinoma 0.673913043 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Renal cell carcinoma 0 0 -0.631402831 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Renal cell carcinoma 0.531304348 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Renal cell carcinoma 0 -0.766798419 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Renal cell carcinoma 0.57826087 0 0 kegg kegg NA NA no no no no no no Yersinia infection Renal cell carcinoma 0 0 -0.517889318 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Renin secretion 0 0 -0.428571429 kegg kegg NA NA no no no no no no ABC transporters Renin secretion -0.620869565 0 0 kegg kegg NA NA no up up no no no Adherens junction Renin secretion 0 0.646245059 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Renin secretion 0 -0.453557312 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Renin secretion 0.613913043 0.75 0.597940798 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Renin secretion -0.646956522 -0.739130435 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Renin secretion 0 -0.587944664 -0.596138996 kegg kegg NA NA no no no no no no AMPK signaling pathway Renin secretion 0 0 0.594851995 kegg kegg NA NA no no no no no no Apelin signaling pathway Renin secretion 0 0.653162055 0 kegg kegg NA NA no no no no no no Apoptosis Renin secretion 0 -0.66798419 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Renin secretion -0.514782609 -0.748023715 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Renin secretion -0.619130435 -0.682806324 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Renin secretion 0 0 -0.586357786 kegg kegg NA NA no no no no no no Autophagy - animal Renin secretion -0.49826087 -0.777667984 -0.461776062 kegg kegg NA NA no no no no no no Autophagy - other Renin secretion 0 -0.475296443 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Renin secretion -0.684347826 -0.766798419 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Renin secretion 0 -0.644268775 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Renin secretion 0.416521739 0.491106719 0.484427284 kegg kegg NA NA no no no no no no Butanoate metabolism Renin secretion 0 0.446640316 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Renin secretion -0.520869565 -0.800395257 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Renin secretion 0.420869565 0.628458498 0.434234234 kegg kegg NA NA no up up no no no Cardiac muscle contraction Renin secretion 0 0.783596838 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Renin secretion 0 -0.524703557 0 kegg kegg NA NA no no no no no no Cell cycle Renin secretion 0 0.455533597 0 kegg kegg NA NA no no no no no no Cellular senescence Renin secretion 0 -0.504940711 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Renin secretion 0 -0.60770751 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Renin secretion 0 -0.529644269 0 kegg kegg NA NA no no no no no no Cholinergic synapse Renin secretion 0 0 -0.423423423 kegg kegg NA NA no no no no no no Circadian entrainment Renin secretion 0.911304348 0.854743083 0.887001287 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Renin secretion 0 0.453557312 0 kegg kegg NA NA no no no no no no Collinsella Renin secretion 0 -0.421497083 0 Genus kegg 0.128 NA no no no no no no Complement and coagulation cascades Renin secretion 0 -0.583003953 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Renin secretion 0 0.5 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Renin secretion 0 -0.414031621 0 kegg kegg NA NA no no no no no no DNA replication Renin secretion 0 0.519762846 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Renin secretion 0.604347826 0.825098814 0.645559846 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Renin secretion 0 0.56916996 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Renin secretion 0 0.565217391 -0.675675676 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Renin secretion 0 0.527667984 0 kegg kegg NA NA no no no no no no Endocrine resistance Renin secretion 0.470434783 0 0.688545689 kegg kegg NA NA no no no no no no Endocytosis Renin secretion 0 -0.483201581 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Renin secretion 0 -0.540513834 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Renin secretion 0.553913043 0.635375494 0.748777349 kegg kegg NA NA no no no no no no Ether lipid metabolism Renin secretion 0 0.511857708 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Renin secretion -0.547826087 -0.739130435 0 kegg kegg NA NA no no no no no no Fatty acid degradation Renin secretion -0.5 -0.684782609 -0.448133848 kegg kegg NA NA no no no no no no Fatty acid metabolism Renin secretion -0.48 -0.604743083 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Renin secretion 0 -0.733201581 -0.509137709 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Renin secretion 0 -0.571146245 0 kegg kegg NA NA no no no no no no Ferroptosis Renin secretion 0.444347826 0 0.419047619 kegg kegg NA NA no no no no no no Focal adhesion Renin secretion 0.426086957 0.570158103 0 kegg kegg NA NA no up up no no no Folate biosynthesis Renin secretion 0 0 -0.400514801 kegg kegg NA NA no no no no no no FoxO signaling pathway Renin secretion 0 -0.586956522 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Renin secretion 0 -0.540513834 -0.602831403 kegg kegg NA NA no no no no no no GABAergic synapse Renin secretion 0 -0.533596838 0 kegg kegg NA NA no up up no no no Galactose metabolism Renin secretion 0 -0.66798419 -0.688030888 kegg kegg NA NA no no no no no no Gap junction Renin secretion 0.754782609 0 0.741827542 kegg kegg NA NA no no no no no no Glucagon signaling pathway Renin secretion 0.731304348 0.835968379 0.543371943 kegg kegg NA NA no no no no no no Glutamatergic synapse Renin secretion 0.590434783 0 0.703732304 kegg kegg NA NA no up up no no no Glutathione metabolism Renin secretion 0.442608696 0.66798419 0.497039897 kegg kegg NA NA no no no no no no Glycerolipid metabolism Renin secretion -0.722608696 -0.510869565 -0.595109395 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Renin secretion -0.407826087 0 -0.418790219 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Renin secretion 0.502608696 0.449604743 0.488030888 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Renin secretion -0.565217391 -0.695652174 -0.552638353 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Renin secretion 0 0 -0.601801802 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Renin secretion 0 0 -0.75984556 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Renin secretion -0.70173913 -0.714426877 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Renin secretion 0.629565217 0.530632411 0.74954955 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Renin secretion 0 0.466403162 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Renin secretion 0.5 0.677865613 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Renin secretion -0.58173913 -0.633399209 -0.684169884 kegg kegg NA NA no no no no no no Histidine metabolism Renin secretion 0 0 -0.423423423 kegg kegg NA NA no no no no no no IL-17 signaling pathway Renin secretion -0.551304348 -0.557312253 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Renin secretion 0.748695652 0.946640316 0.785585586 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Renin secretion -0.44173913 0 0 kegg kegg NA NA no no no no no no Insulin secretion Renin secretion 0.514782609 0.515810277 0.656628057 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Renin secretion 0 0.581027668 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Renin secretion -0.408695652 -0.694664032 0 kegg kegg NA NA no no no no no no Lachnospira Renin secretion 0 0.464047457 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Long-term depression Renin secretion 0.597391304 0 0.741055341 kegg kegg NA NA no no no no no no Longevity regulating pathway Renin secretion 0 0 0.507078507 kegg kegg NA NA no no no no no no Lysosome Renin secretion 0 0 -0.458172458 kegg kegg NA NA no no no no no no MAPK signaling pathway Renin secretion 0 -0.567193676 -0.550579151 kegg kegg NA NA no no no no no no Melanogenesis Renin secretion 0.835652174 0.922924901 0.831660232 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Renin secretion 0 0.546442688 0 kegg kegg NA NA no no no no no no Mismatch repair Renin secretion 0 0.434782609 0 kegg kegg NA NA no no no no no no Mitophagy - animal Renin secretion 0.490434783 0.616600791 0.435006435 kegg kegg NA NA no no no no no no mRNA surveillance pathway Renin secretion 0 0.551383399 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Renin secretion 0 0.503952569 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Renin secretion 0 -0.455533597 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Renin secretion 0 0.621541502 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Renin secretion 0 -0.462450593 0 kegg kegg NA NA no no no no no no Necroptosis Renin secretion 0.476521739 0 0.477992278 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Renin secretion 0 -0.453557312 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Renin secretion 0 -0.682806324 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Renin secretion 0 -0.460474308 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Renin secretion -0.905217391 -0.786561265 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Renin secretion -0.569565217 -0.656126482 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Renin secretion -0.480869565 -0.62055336 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Renin secretion -0.6 -0.84486166 0 kegg kegg NA NA no no no no no no Notch signaling pathway Renin secretion 0 0 -0.54028314 kegg kegg NA NA no no no no no no Nucleotide excision repair Renin secretion 0 0.488142292 0 kegg kegg NA NA no no no no no no Olfactory transduction Renin secretion 0 -0.41798419 0 kegg kegg NA NA no no no no no no One carbon pool by folate Renin secretion 0 0.528656126 0 kegg kegg NA NA no no no no no no Oocyte meiosis Renin secretion 0.412173913 0.4743083 0 kegg kegg NA NA no no no no no no Oscillospira Renin secretion 0 -0.446640316 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Renin secretion -0.687826087 -0.761857708 0 kegg kegg NA NA no no no no no no Other glycan degradation Renin secretion -0.596521739 -0.530632411 -0.591505792 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Renin secretion 0.78 0.556324111 0.792020592 kegg kegg NA NA no up up no no no Oxidative phosphorylation Renin secretion 0 0.821146245 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Renin secretion 0.449565217 0.484189723 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Renin secretion -0.506956522 -0.614624506 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Renin secretion 0 0.550395257 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Renin secretion 0 -0.519762846 0 kegg kegg NA NA no no no no no no Peroxisome Renin secretion -0.580869565 -0.67687747 0 kegg kegg NA NA no no no no no no Phagosome Renin secretion 0 -0.475296443 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Renin secretion 0 0.43972332 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Renin secretion 0 -0.462450593 0 kegg kegg NA NA no up up no no no Phototransduction Renin secretion 0.725217391 0.564229249 0 kegg kegg NA NA no no no no no no Platelet activation Renin secretion 0.56173913 0.632411067 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Renin secretion 0.467826087 0 0.463063063 kegg kegg NA NA no no no no no no PPAR signaling pathway Renin secretion -0.457391304 -0.824110672 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Renin secretion 0 -0.673913043 0 kegg kegg NA NA no no no no no no Propanoate metabolism Renin secretion 0 0.460474308 0 kegg kegg NA NA no no no no no no Proteasome Renin secretion 0 0.438735178 -0.501673102 kegg kegg NA NA no no no no no no Protein export Renin secretion 0 0.666996047 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Renin secretion 0.466956522 0.585968379 0 kegg kegg NA NA no no no no no no Purine metabolism Renin secretion 0 0.442687747 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Renin secretion 0 0.523715415 -0.489317889 kegg kegg NA NA no no no no no no Pyruvate metabolism Renin secretion 0 0.570158103 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Renin secretion 0 0.482213439 0 kegg kegg NA NA no no no no no no Ras signaling pathway Renin secretion 0 0.589920949 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Renin secretion 0.456521739 0.464426877 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Renin secretion 0.742608696 0.518774704 0.836036036 kegg kegg NA NA no no no no no no Renin-angiotensin system Renin secretion 0 -0.516798419 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Renin secretion 0 0.808300395 0 kegg kegg NA NA no no up no no no Ribosome Renin secretion 0 0.694664032 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Renin secretion -0.662608696 -0.802371542 0 kegg kegg NA NA no no no no no no RNA degradation Renin secretion 0 0.608695652 0 kegg kegg NA NA no no no no no no RNA polymerase Renin secretion 0 0.564229249 0 kegg kegg NA NA no no no no no no Serotonergic synapse Renin secretion 0.622608696 0 0.4996139 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Renin secretion -0.657391304 -0.675889328 -0.453796654 kegg kegg NA NA no no no no no no Sphingolipid metabolism Renin secretion 0 0 -0.635263835 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Renin secretion 0 -0.5 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Renin secretion -0.46 -0.70256917 -0.655341055 kegg kegg NA NA no no no no no no Steroid biosynthesis Renin secretion 0.506956522 0.485177866 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Renin secretion 0 0 -0.465379665 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Renin secretion 0 -0.448616601 -0.509395109 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Renin secretion 0 -0.718379447 0 kegg kegg NA NA no no no no no no Taste transduction Renin secretion 0 0.451581028 -0.426769627 kegg kegg NA NA no no up no no no TGF-beta signaling pathway Renin secretion 0 0.668972332 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Renin secretion -0.414782609 -0.583992095 -0.404375804 kegg kegg NA NA no no no no no no Th17 cell differentiation Renin secretion -0.453043478 -0.634387352 0 kegg kegg NA NA no no no no no no Thermogenesis Renin secretion 0.410434783 0.829051383 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Renin secretion 0 0.60770751 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Renin secretion 0.723478261 0.593873518 0.714028314 kegg kegg NA NA no no no no no no Tight junction Renin secretion 0 0.550395257 0 kegg kegg NA NA no no no no no no TNF signaling pathway Renin secretion 0 -0.747035573 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Renin secretion -0.514782609 -0.787549407 0 yes kegg kegg NA NA no no no no no no Tyrosine metabolism Renin secretion 0 0.535573123 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Renin secretion 0.507826087 0.682806324 0.445302445 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Renin secretion 0 0.450592885 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Renin secretion 0.697391304 0.912055336 0.767567568 kegg kegg NA NA no no no no no no VEGF signaling pathway Renin secretion 0 -0.56027668 -0.422651223 kegg kegg NA NA no no no no no no Wnt signaling pathway Renin secretion 0 0.624505929 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Renin-angiotensin system 0 -0.520750988 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Renin-angiotensin system 0 -0.641304348 -0.403346203 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Renin-angiotensin system 0 0.550395257 0.53024453 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Renin-angiotensin system 0 -0.528656126 -0.475933076 kegg kegg NA NA no no no no no no AMPK signaling pathway Renin-angiotensin system -0.566086957 -0.683794466 0 kegg kegg NA NA no no no no no no Antifolate resistance Renin-angiotensin system 0 -0.618577075 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Renin-angiotensin system 0.406956522 0.457509881 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Renin-angiotensin system 0 -0.513833992 0 kegg kegg NA NA no no no no no no Apoptosis Renin-angiotensin system 0 0.748023715 0.442985843 kegg kegg NA NA no no no no no no Arginine and proline metabolism Renin-angiotensin system 0.425217391 0.679841897 0.504247104 kegg kegg NA NA no up no no no no Arginine biosynthesis Renin-angiotensin system 0.485217391 0.595849802 0.582754183 kegg kegg NA NA no no no no no no Autophagy - animal Renin-angiotensin system 0 0.428853755 0.412870013 kegg kegg NA NA no no no no no no Axon guidance Renin-angiotensin system 0 0 0.466924067 kegg kegg NA NA no up up no no no Basal transcription factors Renin-angiotensin system 0 -0.529644269 0 kegg kegg NA NA no no no no no no Base excision repair Renin-angiotensin system 0 -0.626482213 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Renin-angiotensin system 0 0.780632411 0.63037323 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Renin-angiotensin system -0.450434783 -0.726284585 0 kegg kegg NA NA no no no no no no Butanoate metabolism Renin-angiotensin system 0 -0.445652174 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Renin-angiotensin system 0 -0.491106719 0 kegg kegg NA NA no up up no no no Carbon metabolism Renin-angiotensin system 0 0.466403162 0.584555985 kegg kegg NA NA no no no no no no Cardiac muscle contraction Renin-angiotensin system 0 -0.590909091 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Renin-angiotensin system 0 0.711462451 0 kegg kegg NA NA no no no no no no Cell cycle Renin-angiotensin system 0 -0.772727273 -0.487773488 kegg kegg NA NA no no no no no no Cellular senescence Renin-angiotensin system 0 0.675889328 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Renin-angiotensin system 0.589565217 0.876482213 0.65019305 kegg kegg NA NA no no no no no no Chemokine signaling pathway Renin-angiotensin system 0 0.617588933 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Renin-angiotensin system 0 -0.424901186 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Renin-angiotensin system 0.5 0.813241107 0.505791506 kegg kegg NA NA no no no no no no DNA replication Renin-angiotensin system 0 -0.681818182 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Renin-angiotensin system 0 -0.558300395 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Renin-angiotensin system -0.450434783 -0.463438735 0 kegg kegg NA NA no no no no no no Endocrine resistance Renin-angiotensin system -0.543478261 -0.515810277 0 kegg kegg NA NA no no no no no no Endocytosis Renin-angiotensin system 0 0.757905138 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Renin-angiotensin system 0 -0.613636364 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Renin-angiotensin system 0 -0.647233202 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Renin-angiotensin system 0.509565217 0.634387352 0.606435006 kegg kegg NA NA no no no no no no Fatty acid degradation Renin-angiotensin system 0.420869565 0.475296443 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Renin-angiotensin system 0.422608696 0.598814229 0 kegg kegg NA NA no no no no no no Glutathione metabolism Renin-angiotensin system 0 -0.640316206 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Renin-angiotensin system -0.503478261 -0.678853755 0 kegg kegg NA NA no up no no no no Glycosaminoglycan degradation Renin-angiotensin system 0.545217391 0.71541502 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Renin-angiotensin system 0 -0.432806324 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Renin-angiotensin system 0 -0.634387352 -0.442728443 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Renin-angiotensin system 0 0.635375494 0.640926641 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Renin-angiotensin system 0 -0.632411067 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Renin-angiotensin system 0.471304348 0.539525692 0 kegg kegg NA NA no no no no no no Homologous recombination Renin-angiotensin system 0 -0.468379447 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Renin-angiotensin system 0 -0.453557312 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Renin-angiotensin system -0.415652174 0 0 kegg kegg NA NA no no no no no no Lysine degradation Renin-angiotensin system -0.432173913 -0.53458498 -0.407464607 kegg kegg NA NA no no no no no no Lysosome Renin-angiotensin system 0.639130435 0.893280632 0.662033462 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Renin-angiotensin system 0 -0.443675889 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Renin-angiotensin system 0 -0.421936759 0 kegg kegg NA NA no no no no no no Mismatch repair Renin-angiotensin system 0 -0.528656126 0 kegg kegg NA NA no no no no no no Mitophagy - animal Renin-angiotensin system -0.511304348 -0.640316206 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Renin-angiotensin system 0 -0.703557312 -0.444787645 kegg kegg NA NA no no no no no no mTOR signaling pathway Renin-angiotensin system -0.437391304 -0.467391304 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Renin-angiotensin system 0 -0.641304348 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Renin-angiotensin system 0.717391304 0.875494071 0.731016731 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Renin-angiotensin system 0.713043478 0.846837945 0.537966538 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Renin-angiotensin system 0 0.427865613 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Renin-angiotensin system 0.66 0.704545455 0.721492921 kegg kegg NA NA no no no no no no Nitrogen metabolism Renin-angiotensin system 0 0.543478261 0.503474903 kegg kegg NA NA no no no no no no Nucleotide excision repair Renin-angiotensin system 0 -0.660079051 0 kegg kegg NA NA no no no no no no One carbon pool by folate Renin-angiotensin system 0 -0.678853755 -0.441698842 kegg kegg NA NA no no no no no no Osteoclast differentiation Renin-angiotensin system 0.659130435 0.851778656 0.606949807 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Renin-angiotensin system 0 -0.592885375 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Renin-angiotensin system 0 -0.56027668 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Renin-angiotensin system 0.764347826 0.750988142 0.702187902 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Renin-angiotensin system 0 -0.552371542 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Renin-angiotensin system 0.493043478 0.887351779 0.672586873 kegg kegg NA NA no no no no no no Peroxisome Renin-angiotensin system 0.57826087 0.64229249 0.407207207 kegg kegg NA NA no no no no no no Phagosome Renin-angiotensin system 0 0.815217391 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Renin-angiotensin system -0.449565217 -0.671936759 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Renin-angiotensin system 0 0.675889328 0.638867439 kegg kegg NA NA no no no no no no Protein export Renin-angiotensin system 0 -0.425889328 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Renin-angiotensin system -0.42173913 -0.754940711 -0.412355212 kegg kegg NA NA no no no no no no Purine metabolism Renin-angiotensin system 0 -0.779644269 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Renin-angiotensin system 0 -0.611660079 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Renin-angiotensin system 0 -0.541501976 0 kegg kegg NA NA no no no no no no Ribosome Renin-angiotensin system -0.490434783 -0.496047431 -0.453539254 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Renin-angiotensin system 0 -0.748023715 -0.435263835 kegg kegg NA NA no no no no no no RNA degradation Renin-angiotensin system 0 -0.666996047 0 kegg kegg NA NA no no no no no no RNA polymerase Renin-angiotensin system 0 -0.809288538 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Renin-angiotensin system 0 -0.441699605 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Renin-angiotensin system 0 0.688735178 0 kegg kegg NA NA no no no no no no Spliceosome Renin-angiotensin system 0 0 -0.438867439 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Renin-angiotensin system 0.553913043 0.622529644 0.444530245 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Renin-angiotensin system 0 -0.518774704 0 kegg kegg NA NA no no no no no no Thiamine metabolism Renin-angiotensin system 0 -0.460474308 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Renin-angiotensin system 0 -0.51284585 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Renin-angiotensin system 0 -0.463438735 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Renin-angiotensin system -0.59826087 -0.749011858 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Renin-angiotensin system 0 -0.453557312 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Renin-angiotensin system 0 -0.473320158 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Renin-angiotensin system 0 0.458498024 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Renin-angiotensin system 0 -0.718379447 0 kegg kegg NA NA no no no no no no 13-HODE+blood Resistin 0 0.602941176 0 serum_ARA DM-assocaited hormones 0.32 0.156 no no no no no no 14:0/18:2-PC+blood Resistin -0.680082559 0 0 serum_phospholipids DM-assocaited hormones 0.102 0.156 no up no no no no 16:0/20:5-PC+blood Resistin -0.589267286 0 0 serum_phospholipids DM-assocaited hormones 0.628 0.156 no no no no no no 18:0/18:2-PI+blood Resistin 0 0 0.440869565 serum_phospholipids DM-assocaited hormones 0.179 0.156 no no no no no no 18:0/20:3-PC+blood Resistin -0.512899897 0 0 serum_phospholipids DM-assocaited hormones 0.0682 0.156 no up no no no no 18:0/20:4-PI+blood Resistin 0 0 0.486086957 serum_phospholipids DM-assocaited hormones 0.167 0.156 no no no no no no 18:3n6+blood Resistin 0 -0.556372549 0 serum_fattyacid DM-assocaited hormones 0.0463 0.156 up no dn no no no 20:1+blood Resistin 0 0.583333333 0 yes serum_fattyacid DM-assocaited hormones 2.56E-05 0.156 dn dn dn no no no 20:2/18:0-PC+blood Resistin -0.533539732 0 0 serum_phospholipids DM-assocaited hormones 0.0427 0.156 no up no no no no 20:5n3+blood Resistin -0.698658411 0 0 serum_fattyacid DM-assocaited hormones 0.988 0.156 no no no no no no 8-HETE+blood Resistin 0 0.49754902 0 serum_ARA DM-assocaited hormones 0.741 0.156 no no no no no no ACA+blood Resistin 0 0 -0.493773945 serum_bileacids DM-assocaited hormones 0.338 0.156 no no no no no no ACA+stool Resistin -0.579587069 0 0 stool_bileacids DM-assocaited hormones 0.417 0.156 no no no no no no AGE-RAGE signaling pathway in diabetic complications Resistin 0 0 0.401403743 kegg DM-assocaited hormones NA 0.156 no no no no no no Betaine+blood Resistin 0.55624355 0 0 serum_choline DM-assocaited hormones 0.857 0.156 no no no no no no C-peptide Resistin -0.52173913 0 0 DM-assocaited hormones DM-assocaited hormones 0.228 0.156 no no no no no no Creatinine+blood Resistin 0 0.539215686 0 serum_choline DM-assocaited hormones 0.437 0.156 no no no no no no d18:0-24:1-SM+blood Resistin 0.498452012 0 0 serum_phospholipids DM-assocaited hormones 0.0609 0.156 no dn dn no no no d18:1-16:0-SM+blood Resistin 0.477812178 0 0.436521739 serum_phospholipids DM-assocaited hormones 0.14 0.156 no no no no no no d18:1-24:1-SM+blood Resistin 0.477812178 0 0 serum_phospholipids DM-assocaited hormones 0.0123 0.156 no dn dn no no no DCA+stool Resistin 0 0 0.577922078 stool_bileacids DM-assocaited hormones 0.195 0.156 no no no no no no DHA+blood Resistin -0.562435501 0 0 serum_ARA DM-assocaited hormones 0.872 0.156 no no no no no no DPA+blood Resistin -0.545923633 0 0 serum_ARA DM-assocaited hormones 0.519 0.156 no no no no no no EPA+blood Resistin -0.69246646 0 0 serum_ARA DM-assocaited hormones 0.212 0.156 no no no no no no GCA+stool Resistin 0 0 -0.461038961 stool_bileacids DM-assocaited hormones 0.0809 0.156 no no no no no no GCDCA+stool Resistin -0.561764706 0 -0.571428571 yes stool_bileacids DM-assocaited hormones 0.0471 0.156 no dn no no no no GDCA+stool Resistin 0 0 -0.652796391 stool_bileacids DM-assocaited hormones 0.656 0.156 no no no no no no Ghrelin Resistin 0 -0.607826087 -0.457703081 yes DM-assocaited hormones DM-assocaited hormones 0.0108 0.156 dn no no no no no Glucagon Resistin 0 0 -0.48907563 DM-assocaited hormones DM-assocaited hormones 0.0283 0.156 no no up no no no Glycine+blood Resistin 0 0 -0.467826087 serum_aminoacids DM-assocaited hormones 0.00408 0.156 dn no up no no no GPC+blood Resistin 0 0 0.502608696 serum_choline DM-assocaited hormones 0.00427 0.156 no up up no no no IL-1ra Resistin 0 0 0.494252874 yes serum_cytokines DM-assocaited hormones 0.0288 0.156 no up no no no no Insulin Resistin -0.611660079 0 0 yes DM-assocaited hormones DM-assocaited hormones 0.00058 0.156 up up no no no no L-Aspartic acid+blood Resistin 0.473684211 0 0 yes serum_aminoacids DM-assocaited hormones 0.0226 0.156 up up no no no no L-Tryptophan+stool Resistin 0 0.664335664 0 stool_cometabolism DM-assocaited hormones 0.557 0.156 no no no no no no LCA+stool Resistin 0 0 0.480519481 stool_bileacids DM-assocaited hormones 0.314 0.156 no no no no no no Leptin Resistin -0.476284585 0 0 DM-assocaited hormones DM-assocaited hormones 0.706 0.156 no no no no no no n3+blood Resistin -0.527347781 0 0 serum_fattyacid DM-assocaited hormones 0.806 0.156 no no no no no no n6/n3+blood Resistin 0.55624355 0 0 serum_fattyacid DM-assocaited hormones 0.226 0.156 no no no no no no TMAO+blood Resistin 0.568627451 0 0 serum_choline DM-assocaited hormones 0.00706 0.156 up up no no no no UFA%+blood Resistin 0 0.5 0 serum_fattyacid DM-assocaited hormones 0.0236 0.156 no dn no no no no Viral protein interaction with cytokine and cytokine receptor Resistin 0 0.43083004 0 kegg DM-assocaited hormones NA 0.156 no no no no no no alpha-Linolenic acid metabolism Retinol metabolism 0.604347826 0 0.626512227 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Retinol metabolism 0.783478261 0.537549407 0.588674389 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Retinol metabolism 0.491304348 0 0.742084942 kegg kegg NA NA no no no no no no beta-Alanine metabolism Retinol metabolism 0.717391304 0.628458498 0.618532819 kegg kegg NA NA no no no no no no Butanoate metabolism Retinol metabolism 0.604347826 0.749011858 0.634749035 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Retinol metabolism 0.683478261 0.692687747 0.797683398 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Retinol metabolism 0.700869565 0.608695652 0.558301158 kegg kegg NA NA no no no no no no Ether lipid metabolism Retinol metabolism -0.485217391 0 0.464607465 kegg kegg NA NA no no no no no no Fatty acid degradation Retinol metabolism 0.603478261 0 0.502445302 kegg kegg NA NA no no no no no no Fatty acid elongation Retinol metabolism 0.710434783 0.527667984 0.574517375 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Retinol metabolism 0.488695652 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Retinol metabolism 0.509565217 0 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Retinol metabolism 0 0 0.420849421 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Retinol metabolism 0 0 0.47953668 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Retinol metabolism 0 0 -0.466409266 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Retinol metabolism 0.816521739 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Retinol metabolism 0 0.482213439 0.5001287 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Retinol metabolism -0.680869565 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Retinol metabolism 0 0.638339921 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Retinol metabolism -0.717391304 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Retinol metabolism 0.589565217 0.41798419 0.633204633 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Retinol metabolism 0 0 0.544144144 kegg kegg NA NA no no no no no no Linoleic acid metabolism Retinol metabolism 0 0.551383399 0.417760618 kegg kegg NA NA no no no no no no Lysine degradation Retinol metabolism 0 0 0.413384813 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Retinol metabolism -0.746956522 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Retinol metabolism 0.746956522 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Retinol metabolism 0 0.531620553 0.449420849 kegg kegg NA NA no no no no no no One carbon pool by folate Retinol metabolism 0.586956522 0.83201581 0.638352638 kegg kegg NA NA no no no no no no Other glycan degradation Retinol metabolism 0 0 0.482882883 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Retinol metabolism 0 0 0.502960103 kegg kegg NA NA no no no no no no Oxidative phosphorylation Retinol metabolism -0.433043478 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Retinol metabolism 0.694782609 0.618577075 0.543629344 kegg kegg NA NA no no no no no no Phenylalanine metabolism Retinol metabolism 0.506956522 0.749011858 0.421879022 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Retinol metabolism 0.790434783 0.579051383 0.427284427 kegg kegg NA NA no no no no no no Propanoate metabolism Retinol metabolism 0.817391304 0.559288538 0.546460746 kegg kegg NA NA no no no no no no Pyrimidine metabolism Retinol metabolism 0.692173913 0.747035573 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Retinol metabolism 0.786086957 0.557312253 0.494723295 kegg kegg NA NA no no no no no no Selenocompound metabolism Retinol metabolism 0 0.576086957 0.71994852 kegg kegg NA NA no no no no no no Steroid biosynthesis Retinol metabolism 0 0.733201581 0.687516088 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Retinol metabolism 0.752173913 0.764822134 0.658172458 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Retinol metabolism 0.653913043 0.81027668 0.631145431 kegg kegg NA NA no no no no no no Thiamine metabolism Retinol metabolism 0 0.418972332 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Retinol metabolism 0.751304348 0.695652174 0.688803089 kegg kegg NA NA no up no no no no Tyrosine metabolism Retinol metabolism 0.835652174 0.828063241 0.675675676 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Retinol metabolism 0.665217391 0.915019763 0.684169884 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Retinol metabolism 0.722608696 0.816205534 0.796396396 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Retinol metabolism 0 0.498023715 0.536164736 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Retrograde endocannabinoid signaling -0.530434783 0 0 kegg kegg NA NA no no no no no up ABC transporters Retrograde endocannabinoid signaling 0 -0.48715415 0 kegg kegg NA NA no up up no no up Adherens junction Retrograde endocannabinoid signaling 0 0.707509881 0.452509653 kegg kegg NA NA no no no no no up Adrenergic signaling in cardiomyocytes Retrograde endocannabinoid signaling 0.496521739 0.733201581 0 kegg kegg NA NA no no up no no up Akkermansia Retrograde endocannabinoid signaling 0 0 -0.406711468 acetate-producing Genus kegg 0.23 NA no no no no no up "Alanine, aspartate and glutamate metabolism" Retrograde endocannabinoid signaling 0 -0.713438735 -0.62985843 kegg kegg NA NA no no no no no up alpha-Linolenic acid metabolism Retrograde endocannabinoid signaling 0 -0.701581028 0 kegg kegg NA NA no no no no no up Aminoacyl-tRNA biosynthesis Retrograde endocannabinoid signaling -0.526086957 0 0 kegg kegg NA NA no no no no no up AMPK signaling pathway Retrograde endocannabinoid signaling 0 0 -0.493178893 kegg kegg NA NA no no no no no up Apelin signaling pathway Retrograde endocannabinoid signaling 0 0.788537549 0 kegg kegg NA NA no no no no no up Apoptosis Retrograde endocannabinoid signaling 0 -0.617588933 0 kegg kegg NA NA no no no no no up Apoptosis - multiple species Retrograde endocannabinoid signaling 0 -0.551383399 0 kegg kegg NA NA no no no no no up Arginine and proline metabolism Retrograde endocannabinoid signaling 0 -0.697628458 -0.42033462 kegg kegg NA NA no up no no no up Arginine biosynthesis Retrograde endocannabinoid signaling 0 -0.648221344 -0.598198198 kegg kegg NA NA no no no no no up Autophagy - animal Retrograde endocannabinoid signaling 0 -0.758893281 0 kegg kegg NA NA no no no no no up Autophagy - other Retrograde endocannabinoid signaling 0 -0.47826087 0 kegg kegg NA NA no no no no no up Axon guidance Retrograde endocannabinoid signaling 0.433913043 0 0 kegg kegg NA NA no up up no no up B cell receptor signaling pathway Retrograde endocannabinoid signaling 0 -0.666007905 0 kegg kegg NA NA no no no no no up beta-Alanine metabolism Retrograde endocannabinoid signaling -0.553043478 0 0 kegg kegg NA NA no no no no no up Biosynthesis of amino acids Retrograde endocannabinoid signaling -0.52 -0.522727273 -0.432689833 kegg kegg NA NA no no no no no up Biosynthesis of cofactors Retrograde endocannabinoid signaling 0 0 -0.457142857 kegg kegg NA NA no no no no no up Butanoate metabolism Retrograde endocannabinoid signaling -0.477391304 0 0 kegg kegg NA NA no no no no no up C-type lectin receptor signaling pathway Retrograde endocannabinoid signaling 0 -0.697628458 0 kegg kegg NA NA no no no no no up Calcium signaling pathway Retrograde endocannabinoid signaling 0 0.682806324 0 kegg kegg NA NA no up up no no up cAMP signaling pathway Retrograde endocannabinoid signaling 0.594782609 0 0 yes kegg kegg NA NA no up up no no up Carbon metabolism Retrograde endocannabinoid signaling -0.539130435 0 0 kegg kegg NA NA no no no no no up Cardiac muscle contraction Retrograde endocannabinoid signaling 0.83826087 0.897233202 0.802059202 kegg kegg NA NA no no up no no up Cell adhesion molecules Retrograde endocannabinoid signaling -0.52173913 0 0 kegg kegg NA NA no no no no no up Cell cycle Retrograde endocannabinoid signaling 0 0 0.421364221 kegg kegg NA NA no no no no no up Cellular senescence Retrograde endocannabinoid signaling 0 -0.425889328 0 kegg kegg NA NA no no no no no up cGMP-PKG signaling pathway Retrograde endocannabinoid signaling 0 -0.531620553 0 kegg kegg NA NA no no no no no up Circadian entrainment Retrograde endocannabinoid signaling 0 0.673913043 0 kegg kegg NA NA no up up no no up Circadian rhythm Retrograde endocannabinoid signaling 0.464347826 0 0 kegg kegg NA NA no no no no no up Citrate cycle (TCA cycle) Retrograde endocannabinoid signaling 0 0.493083004 0 kegg kegg NA NA no no no no no up Complement and coagulation cascades Retrograde endocannabinoid signaling 0 -0.451581028 0 kegg kegg NA NA no no no no no up Cysteine and methionine metabolism Retrograde endocannabinoid signaling 0 0.549407115 0 kegg kegg NA NA no no no no no up DNA replication Retrograde endocannabinoid signaling 0 0.475296443 0 kegg kegg NA NA no no no no no up Drug metabolism - cytochrome P450 Retrograde endocannabinoid signaling 0 0.570158103 0 kegg kegg NA NA no no no no no up Drug metabolism - other enzymes Retrograde endocannabinoid signaling 0 0.632411067 0 kegg kegg NA NA no no no no no up EGFR tyrosine kinase inhibitor resistance Retrograde endocannabinoid signaling 0 0.677865613 0 kegg kegg NA NA no no no no no up ErbB signaling pathway Retrograde endocannabinoid signaling 0 -0.506916996 0 kegg kegg NA NA no no no no no up Ether lipid metabolism Retrograde endocannabinoid signaling 0.419130435 0 0 kegg kegg NA NA no no no no no up Fatty acid biosynthesis Retrograde endocannabinoid signaling 0 -0.760869565 -0.491119691 kegg kegg NA NA no no no no no up Fatty acid degradation Retrograde endocannabinoid signaling 0 -0.827075099 0 kegg kegg NA NA no no no no no up Fatty acid metabolism Retrograde endocannabinoid signaling -0.433913043 -0.727272727 0 kegg kegg NA NA no no no no no up Fc epsilon RI signaling pathway Retrograde endocannabinoid signaling 0 -0.712450593 0 kegg kegg NA NA no no no no no up Fc gamma R-mediated phagocytosis Retrograde endocannabinoid signaling 0 -0.541501976 0 kegg kegg NA NA no no no no no up Focal adhesion Retrograde endocannabinoid signaling 0 0.62055336 0.501158301 kegg kegg NA NA no up up no no up FoxO signaling pathway Retrograde endocannabinoid signaling 0 -0.783596838 0 kegg kegg NA NA no no no no no up Fructose and mannose metabolism Retrograde endocannabinoid signaling -0.539130435 -0.694664032 -0.41956242 kegg kegg NA NA no no no no no up Galactose metabolism Retrograde endocannabinoid signaling -0.54 -0.736166008 0 kegg kegg NA NA no no no no no up Glutathione metabolism Retrograde endocannabinoid signaling 0 0.781620553 0 kegg kegg NA NA no no no no no up Glycerolipid metabolism Retrograde endocannabinoid signaling 0 -0.677865613 0 kegg kegg NA NA no no up no no up Glycerophospholipid metabolism Retrograde endocannabinoid signaling 0 -0.515810277 0 kegg kegg NA NA no no up no no up "Glycine, serine and threonine metabolism" Retrograde endocannabinoid signaling 0 0 -0.480823681 kegg kegg NA NA no up no no no up Glycolysis / Gluconeogenesis Retrograde endocannabinoid signaling 0 0.528656126 0 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Retrograde endocannabinoid signaling 0 -0.800395257 0 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Retrograde endocannabinoid signaling 0 0 0.470785071 kegg kegg NA NA no no no no no up Glycosphingolipid biosynthesis - globo and isoglobo series Retrograde endocannabinoid signaling 0 0 -0.446846847 kegg kegg NA NA no no no no no up Glycosphingolipid biosynthesis - lacto and neolacto series Retrograde endocannabinoid signaling 0 -0.414031621 0 kegg kegg NA NA no no no no no up Glyoxylate and dicarboxylate metabolism Retrograde endocannabinoid signaling -0.476521739 -0.652173913 -0.580952381 kegg kegg NA NA no no no no no up HIF-1 signaling pathway Retrograde endocannabinoid signaling 0 0.687747036 0 kegg kegg NA NA no no no no no up Hippo signaling pathway Retrograde endocannabinoid signaling 0 0.646245059 0.552123552 kegg kegg NA NA no no no no no up Hippo signaling pathway - multiple species Retrograde endocannabinoid signaling 0 -0.699604743 0 kegg kegg NA NA no no no no no up IL-17 signaling pathway Retrograde endocannabinoid signaling 0 -0.492094862 0 kegg kegg NA NA no no no no no up Inositol phosphate metabolism Retrograde endocannabinoid signaling 0 -0.574110672 0 kegg kegg NA NA no no no no no up JAK-STAT signaling pathway Retrograde endocannabinoid signaling 0 -0.820158103 0 kegg kegg NA NA no no no no no up Linoleic acid metabolism Retrograde endocannabinoid signaling 0 0 0.43037323 kegg kegg NA NA no no no no no up Long-term potentiation Retrograde endocannabinoid signaling 0 0.431818182 0.55984556 kegg kegg NA NA no no up no no up Longevity regulating pathway Retrograde endocannabinoid signaling 0 0 -0.5003861 kegg kegg NA NA no no no no no up Mannose type O-glycan biosynthesis Retrograde endocannabinoid signaling 0 0 0.410810811 kegg kegg NA NA no no no no no up MAPK signaling pathway Retrograde endocannabinoid signaling 0 -0.677865613 0 kegg kegg NA NA no no no no no up Metabolism of xenobiotics by cytochrome P450 Retrograde endocannabinoid signaling 0 0.532608696 0 kegg kegg NA NA no no no no no up Mitophagy - animal Retrograde endocannabinoid signaling 0 0.70256917 0 kegg kegg NA NA no no no no no up mRNA surveillance pathway Retrograde endocannabinoid signaling 0 0.508893281 0.404375804 kegg kegg NA NA no no no no no up mTOR signaling pathway Retrograde endocannabinoid signaling 0 0.658102767 0 kegg kegg NA NA no no no no no up Mucin type O-glycan biosynthesis Retrograde endocannabinoid signaling 0 -0.441699605 0 kegg kegg NA NA no no no no no up N-Glycan biosynthesis Retrograde endocannabinoid signaling 0 0.520750988 0 kegg kegg NA NA no no no no no up Neurotrophin signaling pathway Retrograde endocannabinoid signaling 0.423478261 -0.447628458 0 kegg kegg NA NA no no no no no up NF-kappa B signaling pathway Retrograde endocannabinoid signaling 0 -0.781620553 0 kegg kegg NA NA no no no no no up Nicotinate and nicotinamide metabolism Retrograde endocannabinoid signaling 0 -0.686758893 0 kegg kegg NA NA no no no no no up Nitrogen metabolism Retrograde endocannabinoid signaling 0 -0.513833992 -0.542084942 kegg kegg NA NA no no no no no up NOD-like receptor signaling pathway Retrograde endocannabinoid signaling 0 -0.825098814 -0.417760618 kegg kegg NA NA no no no no no up Non-homologous end-joining Retrograde endocannabinoid signaling -0.452173913 0 0 kegg kegg NA NA no no no no no up Oocyte meiosis Retrograde endocannabinoid signaling 0.475652174 0.544466403 0.525096525 kegg kegg NA NA no no no no no up Oscillospira Retrograde endocannabinoid signaling 0 -0.537549407 0 LPS-producing Genus kegg 0.62 NA no no no no no up Osteoclast differentiation Retrograde endocannabinoid signaling 0 -0.719367589 0 kegg kegg NA NA no no no no no up Other glycan degradation Retrograde endocannabinoid signaling 0 -0.622529644 0 kegg kegg NA NA no no no no no up Oxidative phosphorylation Retrograde endocannabinoid signaling 0.854782609 0.929841897 0.778120978 kegg kegg NA NA no no no no no up Pantothenate and CoA biosynthesis Retrograde endocannabinoid signaling 0 -0.700592885 -0.424453024 kegg kegg NA NA no no dn no no up Pentose and glucuronate interconversions Retrograde endocannabinoid signaling 0 0.522727273 0.471042471 kegg kegg NA NA no no no no no up Pentose phosphate pathway Retrograde endocannabinoid signaling 0 -0.436758893 -0.468468468 kegg kegg NA NA no no no no no up Peroxisome Retrograde endocannabinoid signaling 0 -0.665019763 -0.464350064 kegg kegg NA NA no no no no no up Phagosome Retrograde endocannabinoid signaling -0.473913043 0 0 kegg kegg NA NA no no no no no up Phosphatidylinositol signaling system Retrograde endocannabinoid signaling 0 0 0.401029601 kegg kegg NA NA no no no no no up Phospholipase D signaling pathway Retrograde endocannabinoid signaling 0 -0.584980237 0 kegg kegg NA NA no up up no no up Platelet activation Retrograde endocannabinoid signaling 0 0.62055336 0 kegg kegg NA NA no no no no no up Platinum drug resistance Retrograde endocannabinoid signaling 0 -0.4743083 0 kegg kegg NA NA no no no no no up Porphyrin and chlorophyll metabolism Retrograde endocannabinoid signaling 0 0 -0.464092664 kegg kegg NA NA no no no no no up PPAR signaling pathway Retrograde endocannabinoid signaling 0 -0.621541502 0 kegg kegg NA NA no no no no no up Propanoate metabolism Retrograde endocannabinoid signaling 0 0.538537549 0 kegg kegg NA NA no no no no no up Proteasome Retrograde endocannabinoid signaling 0 0.504940711 0 kegg kegg NA NA no no no no no up Protein export Retrograde endocannabinoid signaling 0 0.745059289 0.561389961 kegg kegg NA NA no no no no no up Protein processing in endoplasmic reticulum Retrograde endocannabinoid signaling 0 0.579051383 0 kegg kegg NA NA no no no no no up Purine metabolism Retrograde endocannabinoid signaling -0.424347826 0 -0.477734878 kegg kegg NA NA no no no no no up Pyrimidine metabolism Retrograde endocannabinoid signaling -0.435652174 0.427865613 0 kegg kegg NA NA no no no no no up Pyruvate metabolism Retrograde endocannabinoid signaling 0 0.624505929 0 kegg kegg NA NA no no no no no up Rap1 signaling pathway Retrograde endocannabinoid signaling 0 0.480237154 0 kegg kegg NA NA no no no no no up Ras signaling pathway Retrograde endocannabinoid signaling 0 0.605731225 0.623938224 yes kegg kegg NA NA no up up no no up Renin-angiotensin system Retrograde endocannabinoid signaling 0 -0.509881423 0 kegg kegg NA NA no no no no no up Ribosome Retrograde endocannabinoid signaling 0 0.868577075 0 kegg kegg NA NA no no no no no up RIG-I-like receptor signaling pathway Retrograde endocannabinoid signaling 0 -0.736166008 0 kegg kegg NA NA no no no no no up RNA degradation Retrograde endocannabinoid signaling 0 0.581027668 0.431145431 kegg kegg NA NA no no no no no up RNA polymerase Retrograde endocannabinoid signaling 0 0.462450593 0 kegg kegg NA NA no no no no no up RNA transport Retrograde endocannabinoid signaling 0 0.536561265 0 kegg kegg NA NA no no no no no up SNARE interactions in vesicular transport Retrograde endocannabinoid signaling 0 -0.726284585 0 kegg kegg NA NA no no no no no up Starch and sucrose metabolism Retrograde endocannabinoid signaling 0 -0.768774704 0 kegg kegg NA NA no no no no no up Steroid biosynthesis Retrograde endocannabinoid signaling 0 0 0.400514801 kegg kegg NA NA no no no no no up Sulfur metabolism Retrograde endocannabinoid signaling -0.46173913 0 -0.501415701 kegg kegg NA NA no no no no no up T cell receptor signaling pathway Retrograde endocannabinoid signaling 0 -0.595849802 0 kegg kegg NA NA no no no no no up Taurine and hypotaurine metabolism Retrograde endocannabinoid signaling 0 -0.536561265 0 kegg kegg NA NA no no no no no up TGF-beta signaling pathway Retrograde endocannabinoid signaling 0.571304348 0.708498024 0.605920206 kegg kegg NA NA no no no no no up Th1 and Th2 cell differentiation Retrograde endocannabinoid signaling 0 -0.541501976 0 kegg kegg NA NA no no no no no up Th17 cell differentiation Retrograde endocannabinoid signaling 0 -0.562252964 0 kegg kegg NA NA no no no no no up Thermogenesis Retrograde endocannabinoid signaling 0.748695652 0.925889328 0.744658945 kegg kegg NA NA no no no no no up Thiamine metabolism Retrograde endocannabinoid signaling 0 0.446640316 0 kegg kegg NA NA no no no no no up Tight junction Retrograde endocannabinoid signaling 0 0.631422925 0 kegg kegg NA NA no no no no no up TNF signaling pathway Retrograde endocannabinoid signaling 0 -0.652173913 0 kegg kegg NA NA no no no no no up Toll-like receptor signaling pathway Retrograde endocannabinoid signaling 0 -0.695652174 0 yes kegg kegg NA NA no no no no no up Tyrosine metabolism Retrograde endocannabinoid signaling 0 0.424901186 0 kegg kegg NA NA no no no no no up Ubiquitin mediated proteolysis Retrograde endocannabinoid signaling 0 0.713438735 0 kegg kegg NA NA no no no no no up Vascular smooth muscle contraction Retrograde endocannabinoid signaling 0.494782609 0.872529644 0 kegg kegg NA NA no no no no no up VEGF signaling pathway Retrograde endocannabinoid signaling 0 0 0.425740026 kegg kegg NA NA no no no no no up Wnt signaling pathway Retrograde endocannabinoid signaling 0.453913043 0.579051383 0.624195624 kegg kegg NA NA no no no no no up 2-Oxocarboxylic acid metabolism Rheumatoid arthritis 0.52173913 0 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Rheumatoid arthritis 0 -0.68083004 0 kegg kegg NA NA no no up no no no African trypanosomiasis Rheumatoid arthritis -0.507826087 0 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Rheumatoid arthritis 0 0.51284585 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Rheumatoid arthritis 0 0.456521739 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Rheumatoid arthritis 0 -0.834980237 0 kegg kegg NA NA no up up no no no Alzheimer disease Rheumatoid arthritis -0.47826087 -0.577075099 0 kegg kegg NA NA no no no no no no Amoebiasis Rheumatoid arthritis 0 0.419960474 0 kegg kegg NA NA no no no no no no Amphetamine addiction Rheumatoid arthritis -0.466086957 -0.825098814 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Rheumatoid arthritis 0 -0.725296443 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Rheumatoid arthritis -0.448695652 -0.62944664 0 kegg kegg NA NA no no no no no no Antifolate resistance Rheumatoid arthritis 0 -0.538537549 -0.461261261 kegg kegg NA NA no no no no no no Antigen processing and presentation Rheumatoid arthritis 0 0.441699605 0.513256113 kegg kegg NA NA no no no no no no Apelin signaling pathway Rheumatoid arthritis -0.480869565 -0.429841897 0 kegg kegg NA NA no no no no no no Apoptosis Rheumatoid arthritis 0 0.700592885 0.444787645 kegg kegg NA NA no no no no no no Arginine and proline metabolism Rheumatoid arthritis 0 0.59486166 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Rheumatoid arthritis 0 0.484189723 0 kegg kegg NA NA no no no no no no Asthma Rheumatoid arthritis 0.790434783 0.428853755 0.8 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Rheumatoid arthritis 0.647826087 0.739130435 0.415444015 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Rheumatoid arthritis 0 0.591897233 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Rheumatoid arthritis 0 0 0.546203346 kegg kegg NA NA no no no no no no Basal cell carcinoma Rheumatoid arthritis -0.446956522 -0.552371542 -0.604633205 kegg kegg NA NA no no no no no no Basal transcription factors Rheumatoid arthritis 0 -0.653162055 -0.417503218 kegg kegg NA NA no no no no no no Base excision repair Rheumatoid arthritis 0 -0.580039526 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Rheumatoid arthritis 0.515652174 0 0.614671815 kegg kegg NA NA no no no no no no Bile secretion Rheumatoid arthritis 0 -0.4743083 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Rheumatoid arthritis 0.537391304 0.793478261 0.57992278 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Rheumatoid arthritis 0 -0.687747036 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Rheumatoid arthritis 0 0 0.432947233 kegg kegg NA NA no no no no no no Bladder cancer Rheumatoid arthritis 0 0.531620553 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Rheumatoid arthritis 0 0.588932806 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Rheumatoid arthritis 0 -0.564229249 -0.423680824 kegg kegg NA NA no up up no no no cAMP signaling pathway Rheumatoid arthritis -0.51826087 0 -0.402316602 yes kegg kegg NA NA no up up no no no Carbon metabolism Rheumatoid arthritis 0.51826087 0.636363636 0.683655084 kegg kegg NA NA no no no no no no Cardiac muscle contraction Rheumatoid arthritis -0.432173913 -0.566205534 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Rheumatoid arthritis 0.625217391 0.816205534 0.544658945 kegg kegg NA NA no no no no no no Cell cycle Rheumatoid arthritis -0.495652174 -0.768774704 0 kegg kegg NA NA no no no no no no Cellular senescence Rheumatoid arthritis 0 0.662055336 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Rheumatoid arthritis 0 0.812252964 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Rheumatoid arthritis 0 0.513833992 0.438352638 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Rheumatoid arthritis -0.515652174 -0.707509881 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Rheumatoid arthritis 0 0.543478261 0 kegg kegg NA NA no no no no no no Cholesterol metabolism Rheumatoid arthritis 0 0.767786561 0 yes kegg kegg NA NA no no up no no no Circadian rhythm Rheumatoid arthritis -0.566086957 -0.77173913 -0.518661519 kegg kegg NA NA no no no no no no Cocaine addiction Rheumatoid arthritis 0 -0.68083004 0 kegg kegg NA NA no no no no no no Colorectal cancer Rheumatoid arthritis -0.439130435 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Rheumatoid arthritis 0 0.764822134 0.667953668 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Rheumatoid arthritis -0.484347826 -0.421936759 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Rheumatoid arthritis 0 -0.75 0 kegg kegg NA NA no no up no no no Cushing syndrome Rheumatoid arthritis -0.44173913 -0.854743083 -0.475160875 kegg kegg NA NA no no up no no no DNA replication Rheumatoid arthritis 0 -0.538537549 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Rheumatoid arthritis -0.47826087 -0.585968379 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Rheumatoid arthritis 0 0 0.403861004 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Rheumatoid arthritis 0 -0.750988142 0 kegg kegg NA NA no no no no no no Endocrine resistance Rheumatoid arthritis 0 -0.649209486 0 kegg kegg NA NA no no no no no no Endocytosis Rheumatoid arthritis 0 0.787549407 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Rheumatoid arthritis 0 0.717391304 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Rheumatoid arthritis 0 0.431818182 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Rheumatoid arthritis 0 -0.514822134 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Rheumatoid arthritis -0.422608696 -0.636363636 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Rheumatoid arthritis 0 -0.576086957 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Rheumatoid arthritis 0 0.65513834 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Rheumatoid arthritis 0 0.545454545 0 kegg kegg NA NA no no no no no no Fatty acid degradation Rheumatoid arthritis 0 0.495059289 0 kegg kegg NA NA no no no no no no Fatty acid elongation Rheumatoid arthritis 0 0 0.49034749 kegg kegg NA NA no no no no no no Fatty acid metabolism Rheumatoid arthritis 0 0.585968379 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Rheumatoid arthritis 0 0.636363636 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Rheumatoid arthritis 0 0.83201581 0.524839125 kegg kegg NA NA no no no no no no Focal adhesion Rheumatoid arthritis 0 0 0.496782497 kegg kegg NA NA no up up no no no Folate biosynthesis Rheumatoid arthritis -0.539130435 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Rheumatoid arthritis 0.442608696 0 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Rheumatoid arthritis -0.488695652 -0.866600791 -0.453796654 kegg kegg NA NA no no no no no no Glutathione metabolism Rheumatoid arthritis 0 -0.611660079 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Rheumatoid arthritis 0 0 -0.404633205 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Rheumatoid arthritis 0 -0.653162055 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Rheumatoid arthritis 0 0 0.62007722 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Rheumatoid arthritis 0 0.730237154 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Rheumatoid arthritis 0 0 -0.477992278 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Rheumatoid arthritis 0 -0.593873518 -0.424195624 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Rheumatoid arthritis 0 0.541501976 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Rheumatoid arthritis 0 -0.672924901 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Rheumatoid arthritis 0 -0.592885375 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Rheumatoid arthritis 0.485217391 0 0.660746461 kegg kegg NA NA no no no no no no Hepatitis C Rheumatoid arthritis -0.45826087 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Rheumatoid arthritis 0 0 0.403861004 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Rheumatoid arthritis 0 0.444664032 0 kegg kegg NA NA no no no no no no Histidine metabolism Rheumatoid arthritis 0 0 0.42033462 kegg kegg NA NA no no no no no no Homologous recombination Rheumatoid arthritis 0 -0.437747036 0 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Rheumatoid arthritis 0 0.43083004 0 kegg kegg NA NA no no dn no no no Human immunodeficiency virus 1 infection Rheumatoid arthritis 0 0.415019763 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Rheumatoid arthritis 0 0.593873518 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Rheumatoid arthritis 0 0 0.426254826 kegg kegg NA NA no no no no no no Huntington disease Rheumatoid arthritis -0.427826087 -0.596837945 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Rheumatoid arthritis 0 0.828063241 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Rheumatoid arthritis 0.649565217 0.641304348 0.742084942 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Rheumatoid arthritis 0 -0.682806324 0 kegg kegg NA NA no no no no no no Influenza A Rheumatoid arthritis 0.724347826 0.720355731 0.63037323 kegg kegg NA NA no no no no no no Insulin resistance Rheumatoid arthritis -0.499130435 0 -0.552638353 kegg kegg NA NA no no no no no no Insulin secretion Rheumatoid arthritis 0 -0.767786561 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Rheumatoid arthritis -0.44 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Rheumatoid arthritis 0.484347826 0 0.677992278 kegg kegg NA NA no no no no no no Leishmaniasis Rheumatoid arthritis 0 0 0.485456885 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Rheumatoid arthritis 0 0 0.658687259 kegg kegg NA NA no no no no no no Long-term potentiation Rheumatoid arthritis -0.509565217 0 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Rheumatoid arthritis 0 -0.416007905 0 kegg kegg NA NA no no no no no no Lysine degradation Rheumatoid arthritis 0 -0.505928854 0 kegg kegg NA NA no no no no no no Lysosome Rheumatoid arthritis 0 0.898221344 0.438610039 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Rheumatoid arthritis 0 0 -0.404375804 kegg kegg NA NA no no no no no no MAPK signaling pathway Rheumatoid arthritis -0.424347826 0 0 kegg kegg NA NA no no no no no no Measles Rheumatoid arthritis -0.489565217 0 0 kegg kegg NA NA no no no no no no Melanogenesis Rheumatoid arthritis 0 -0.701581028 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Rheumatoid arthritis 0 0 0.44993565 kegg kegg NA NA no no no no no no Mineral absorption Rheumatoid arthritis 0 -0.442687747 0 kegg kegg NA NA no no no no no no Mismatch repair Rheumatoid arthritis 0 -0.456521739 0 kegg kegg NA NA no no no no no no Mitophagy - animal Rheumatoid arthritis 0 -0.634387352 0 kegg kegg NA NA no no no no no no Morphine addiction Rheumatoid arthritis 0 -0.639328063 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Rheumatoid arthritis -0.515652174 -0.717391304 -0.573230373 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Rheumatoid arthritis 0 -0.561264822 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Rheumatoid arthritis 0.412173913 0.719367589 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Rheumatoid arthritis 0 0.841897233 0.466666667 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Rheumatoid arthritis 0 0.436758893 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Rheumatoid arthritis 0 0.793478261 0.552638353 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Rheumatoid arthritis 0 0.581027668 0 kegg kegg NA NA no no no no no no Nicotine addiction Rheumatoid arthritis 0 -0.436758893 0 kegg kegg NA NA no up up no no no NOD-like receptor signaling pathway Rheumatoid arthritis 0 0.62944664 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Rheumatoid arthritis -0.495652174 -0.566205534 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Rheumatoid arthritis 0 -0.608695652 0 kegg kegg NA NA no no no no no no Olfactory transduction Rheumatoid arthritis 0 0.712450593 0 kegg kegg NA NA no no no no no no One carbon pool by folate Rheumatoid arthritis 0 -0.604743083 0 kegg kegg NA NA no no no no no no Oocyte meiosis Rheumatoid arthritis -0.474782609 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Rheumatoid arthritis 0 0.772727273 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Rheumatoid arthritis -0.566956522 -0.621541502 -0.412097812 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Rheumatoid arthritis 0 -0.561264822 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Rheumatoid arthritis -0.446956522 -0.56027668 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Rheumatoid arthritis 0 0 0.562419562 kegg kegg NA NA no no no no no no p53 signaling pathway Rheumatoid arthritis 0 -0.43972332 -0.542599743 kegg kegg NA NA no no no no no no Pancreatic secretion Rheumatoid arthritis 0 -0.559288538 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Rheumatoid arthritis 0 0.648221344 0 kegg kegg NA NA no no dn no no no Paraprevotella Rheumatoid arthritis 0.446607204 0 0 Genus kegg 0.118 NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Rheumatoid arthritis -0.579130435 -0.570158103 0 kegg kegg NA NA no no no no no no Parkinson disease Rheumatoid arthritis -0.493043478 -0.595849802 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Rheumatoid arthritis 0 0.817193676 0.6002574 kegg kegg NA NA no no no no no no Pathways in cancer Rheumatoid arthritis -0.496521739 0 -0.585842986 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Rheumatoid arthritis -0.466086957 -0.631422925 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Rheumatoid arthritis 0 0.871541502 0.457142857 kegg kegg NA NA no no no no no no Peroxisome Rheumatoid arthritis 0 0.596837945 0 kegg kegg NA NA no no no no no no Pertussis Rheumatoid arthritis 0.603478261 0.880434783 0.605405405 kegg kegg NA NA no no dn no no no Phagosome Rheumatoid arthritis 0.593913043 0.867588933 0.578893179 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Rheumatoid arthritis 0 -0.495059289 -0.465637066 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Rheumatoid arthritis -0.533043478 0 0 yes kegg kegg NA NA no up up no no no Platelet activation Rheumatoid arthritis 0 0 0.402059202 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Rheumatoid arthritis 0 -0.604743083 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Rheumatoid arthritis 0 0.679841897 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Rheumatoid arthritis 0 0 0.575289575 kegg kegg NA NA no no no no no no Prion disease Rheumatoid arthritis -0.424347826 -0.517786561 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Rheumatoid arthritis 0 0.481225296 0 kegg kegg NA NA no no no no no no Prostate cancer Rheumatoid arthritis 0 0 -0.431660232 kegg kegg NA NA no no no no no no Protein digestion and absorption Rheumatoid arthritis 0.537391304 0.679841897 0 yes kegg kegg NA NA no up up no no no Protein export Rheumatoid arthritis -0.414782609 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Rheumatoid arthritis 0 -0.66798419 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Rheumatoid arthritis 0 -0.481225296 0 kegg kegg NA NA no no no no no no Purine metabolism Rheumatoid arthritis 0 -0.772727273 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Rheumatoid arthritis 0 -0.546442688 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Rheumatoid arthritis 0 -0.576086957 0 kegg kegg NA NA no no no no no no Renin secretion Rheumatoid arthritis 0 -0.601778656 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Rheumatoid arthritis 0 0.887351779 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Rheumatoid arthritis -0.499130435 -0.516798419 0 kegg kegg NA NA no no up no no no Ribosome Rheumatoid arthritis -0.473913043 -0.43972332 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Rheumatoid arthritis 0 -0.709486166 0 kegg kegg NA NA no no no no no no RNA degradation Rheumatoid arthritis 0 -0.601778656 0 kegg kegg NA NA no no no no no no RNA polymerase Rheumatoid arthritis 0 -0.77173913 0 kegg kegg NA NA no no no no no no Salmonella infection Rheumatoid arthritis 0 0.818181818 0.736936937 kegg kegg NA NA no no no no no no Selenocompound metabolism Rheumatoid arthritis 0 -0.467391304 0 kegg kegg NA NA no no no no no no Shigellosis Rheumatoid arthritis 0 -0.428853755 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Rheumatoid arthritis -0.483478261 0 0 kegg kegg NA NA no no no no no no Small cell lung cancer Rheumatoid arthritis 0 0 -0.614157014 kegg kegg NA NA no no up no no no Sphingolipid signaling pathway Rheumatoid arthritis 0 0.591897233 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Rheumatoid arthritis 0 -0.577075099 0 kegg kegg NA NA no no no no no no Spliceosome Rheumatoid arthritis 0 -0.435770751 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Rheumatoid arthritis 0.733043478 0.940711462 0.803861004 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Rheumatoid arthritis 0 0.570158103 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Rheumatoid arthritis 0 0.747035573 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Rheumatoid arthritis 0 -0.466403162 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Rheumatoid arthritis 0.560869565 0.915019763 0.76010296 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Rheumatoid arthritis -0.477391304 0 0 kegg kegg NA NA no no no no no no Taste transduction Rheumatoid arthritis -0.637391304 -0.618577075 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Rheumatoid arthritis 0 0 -0.408494208 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Rheumatoid arthritis 0 0.554347826 0.422136422 kegg kegg NA NA no no no no no no Th17 cell differentiation Rheumatoid arthritis 0 0.518774704 0.411325611 kegg kegg NA NA no no no no no no Thermogenesis Rheumatoid arthritis -0.44173913 -0.576086957 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Rheumatoid arthritis 0 -0.697628458 0 kegg kegg NA NA no no no no no no Tight junction Rheumatoid arthritis 0 0 0.503732304 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Rheumatoid arthritis 0 0.643280632 0 yes kegg kegg NA NA no no no no no no Toxoplasmosis Rheumatoid arthritis 0.582608696 0.760869565 0.694208494 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Rheumatoid arthritis 0 0 -0.466924067 kegg kegg NA NA no no no no no no Tuberculosis Rheumatoid arthritis 0.692173913 0.964426877 0.819047619 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Rheumatoid arthritis 0.647826087 0.73715415 0.409266409 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Rheumatoid arthritis 0 -0.727272727 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Rheumatoid arthritis -0.484347826 -0.45256917 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Rheumatoid arthritis 0 -0.669960474 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Rheumatoid arthritis 0 0.704545455 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Rheumatoid arthritis -0.479130435 -0.664031621 -0.430888031 kegg kegg NA NA no no no no no no Yersinia infection Rheumatoid arthritis 0 0.786561265 0 kegg kegg NA NA no no no no no no ABC transporters Ribosome 0 -0.510869565 0 kegg kegg NA NA no up up no no no Akkermansia Ribosome -0.465558296 0 0 acetate-producing Genus kegg 0.23 NA no no no no no no "Alanine, aspartate and glutamate metabolism" Ribosome -0.546956522 -0.669960474 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Ribosome -0.519130435 -0.813241107 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Ribosome -0.549565217 -0.424901186 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Ribosome -0.44 -0.695652174 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Ribosome -0.619130435 -0.613636364 0 kegg kegg NA NA no no no no no no Bacteroides Ribosome -0.419130435 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no beta-Alanine metabolism Ribosome -0.603478261 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Ribosome -0.780869565 -0.502964427 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Ribosome -0.515652174 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Ribosome 0 0.43972332 0.542084942 kegg kegg NA NA no no no no no no Carbon metabolism Ribosome -0.635652174 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Ribosome 0 0.473320158 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Ribosome 0 0.651185771 0.544916345 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Ribosome 0 0.543478261 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Ribosome 0 0.589920949 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Ribosome 0.713913043 0.899209486 0.817245817 kegg kegg NA NA no no no no no no Ether lipid metabolism Ribosome 0.691304348 0 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Ribosome -0.503478261 -0.700592885 0 kegg kegg NA NA no no no no no no Fatty acid degradation Ribosome -0.626956522 -0.690711462 0 kegg kegg NA NA no no no no no no Fatty acid elongation Ribosome -0.568695652 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Ribosome -0.746956522 -0.640316206 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Ribosome -0.559130435 -0.691699605 0 kegg kegg NA NA no no no no no no Galactose metabolism Ribosome -0.70173913 -0.757905138 0 kegg kegg NA NA no no no no no no Glutathione metabolism Ribosome 0 0.730237154 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Ribosome 0 -0.70256917 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Ribosome 0 -0.529644269 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Ribosome -0.508695652 0.616600791 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Ribosome 0 -0.763833992 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Ribosome 0.533913043 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Ribosome 0 -0.53458498 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Ribosome 0 -0.492094862 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Ribosome -0.633913043 -0.588932806 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Ribosome 0 -0.533596838 0 kegg kegg NA NA no no no no no no Lysine degradation Ribosome 0.442608696 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Ribosome 0.62 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Ribosome 0 0.48715415 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Ribosome 0 0.513833992 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Ribosome -0.540869565 -0.708498024 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Ribosome -0.572173913 -0.499011858 0 kegg kegg NA NA no no no no no no Oscillospira Ribosome 0 -0.469367589 0 LPS-producing Genus kegg 0.62 NA no no no no no no Other glycan degradation Ribosome 0 -0.628458498 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Ribosome 0.467826087 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Ribosome 0.690434783 0.862648221 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Ribosome -0.634782609 -0.746047431 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Ribosome 0 0.500988142 0.421106821 kegg kegg NA NA no no no no no no Pentose phosphate pathway Ribosome -0.656521739 -0.48715415 0 kegg kegg NA NA no no no no no no Propanoate metabolism Ribosome 0 0.662055336 0.64993565 kegg kegg NA NA no no no no no no Pyrimidine metabolism Ribosome -0.480869565 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Ribosome 0 0.72826087 0.594594595 kegg kegg NA NA no no no no no no Retinol metabolism Ribosome -0.489565217 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Ribosome 0.426956522 0 0 kegg kegg NA NA no no no no no no Ruminococcus Ribosome 0.443478261 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Starch and sucrose metabolism Ribosome -0.648695652 -0.764822134 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Ribosome 0 -0.472332016 0 kegg kegg NA NA no no no no no no Thiamine metabolism Ribosome 0 0.587944664 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Ribosome biogenesis in eukaryotes 0 0.644268775 0.45997426 kegg kegg NA NA no no no no no no ABC transporters Ribosome biogenesis in eukaryotes 0 0 0.416731017 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" Ribosome biogenesis in eukaryotes 0 -0.506916996 -0.481853282 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Ribosome biogenesis in eukaryotes 0 0.446640316 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Ribosome biogenesis in eukaryotes 0.533913043 0.841897233 0.706821107 kegg kegg NA NA no no no no no no Antifolate resistance Ribosome biogenesis in eukaryotes 0 0.690711462 0.444272844 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Ribosome biogenesis in eukaryotes 0 0 -0.566537967 kegg kegg NA NA no no no no no no Arginine and proline metabolism Ribosome biogenesis in eukaryotes 0 -0.686758893 -0.459202059 kegg kegg NA NA no up no no no no Arginine biosynthesis Ribosome biogenesis in eukaryotes 0 -0.583003953 -0.637323037 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Ribosome biogenesis in eukaryotes 0 0 0.540540541 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Ribosome biogenesis in eukaryotes -0.433913043 -0.712450593 -0.73976834 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Ribosome biogenesis in eukaryotes 0 0.635375494 0 kegg kegg NA NA no no no no no no Butanoate metabolism Ribosome biogenesis in eukaryotes 0 0.645256917 0.47953668 kegg kegg NA NA no no no no no no Carbon metabolism Ribosome biogenesis in eukaryotes 0 0 -0.447361647 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Ribosome biogenesis in eukaryotes 0 0.617588933 0.663063063 kegg kegg NA NA no no no no no no Coprococcus Ribosome biogenesis in eukaryotes 0.436521739 0 0 butyrate-producing Genus kegg 0.612 NA no no no no no no Cysteine and methionine metabolism Ribosome biogenesis in eukaryotes 0.499130435 0.613636364 0.656113256 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Ribosome biogenesis in eukaryotes 0 0.598814229 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Ribosome biogenesis in eukaryotes 0.66173913 0 0.494723295 kegg kegg NA NA no no no no no no Ether lipid metabolism Ribosome biogenesis in eukaryotes 0 0.587944664 0.580952381 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Ribosome biogenesis in eukaryotes 0 -0.526679842 0 kegg kegg NA NA no no no no no no Folate biosynthesis Ribosome biogenesis in eukaryotes 0 0.428853755 0 kegg kegg NA NA no no no no no no Glutathione metabolism Ribosome biogenesis in eukaryotes 0 0 -0.419305019 kegg kegg NA NA no no no no no no Glycerolipid metabolism Ribosome biogenesis in eukaryotes 0 0 0.596653797 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Ribosome biogenesis in eukaryotes 0.45826087 0 0.737451737 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Ribosome biogenesis in eukaryotes 0 0.462450593 -0.425997426 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Ribosome biogenesis in eukaryotes -0.493913043 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Ribosome biogenesis in eukaryotes 0 0.523715415 0.477477477 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Ribosome biogenesis in eukaryotes -0.766086957 -0.559288538 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Ribosome biogenesis in eukaryotes 0 0.668972332 0.420849421 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Ribosome biogenesis in eukaryotes -0.508695652 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Ribosome biogenesis in eukaryotes 0.693913043 0.600790514 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Ribosome biogenesis in eukaryotes 0 -0.610671937 -0.614929215 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Ribosome biogenesis in eukaryotes 0 0.443675889 0.679279279 kegg kegg NA NA no no no no no no Lysine degradation Ribosome biogenesis in eukaryotes 0.706086957 0.674901186 0.795881596 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Ribosome biogenesis in eukaryotes 0 0.489130435 0.709137709 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Ribosome biogenesis in eukaryotes 0 0.507905138 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Ribosome biogenesis in eukaryotes 0.79826087 0.735177866 0.835263835 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Ribosome biogenesis in eukaryotes 0 -0.652173913 -0.58970399 kegg kegg NA NA no no no no no no Nitrogen metabolism Ribosome biogenesis in eukaryotes -0.573043478 -0.641304348 -0.661776062 kegg kegg NA NA no no no no no no One carbon pool by folate Ribosome biogenesis in eukaryotes 0.768695652 0.862648221 0.85997426 kegg kegg NA NA no no no no no no Other glycan degradation Ribosome biogenesis in eukaryotes 0 0 0.48030888 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Ribosome biogenesis in eukaryotes 0.713913043 0.692687747 0.851480051 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Ribosome biogenesis in eukaryotes 0 -0.520750988 0 kegg kegg NA NA no no dn no no no Paraprevotella Ribosome biogenesis in eukaryotes 0 0.47766557 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Ribosome biogenesis in eukaryotes 0 0.705533597 0.635778636 kegg kegg NA NA no no no no no no Pentose phosphate pathway Ribosome biogenesis in eukaryotes -0.688695652 -0.798418972 -0.732303732 kegg kegg NA NA no no no no no no Phenylalanine metabolism Ribosome biogenesis in eukaryotes 0 0.541501976 0 kegg kegg NA NA no no no no no no Platinum drug resistance Ribosome biogenesis in eukaryotes 0.757391304 0.600790514 0.603603604 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Ribosome biogenesis in eukaryotes 0 0 -0.406177606 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Ribosome biogenesis in eukaryotes 0.419130435 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Ribosome biogenesis in eukaryotes 0 0.530632411 0.571171171 kegg kegg NA NA no no no no no no Purine metabolism Ribosome biogenesis in eukaryotes 0 0.527667984 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Ribosome biogenesis in eukaryotes 0 0.661067194 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Ribosome biogenesis in eukaryotes 0.520869565 0.62055336 0.42960103 kegg kegg NA NA no no no no no no Retinol metabolism Ribosome biogenesis in eukaryotes 0 0.657114625 0.586872587 kegg kegg NA NA no no no no no no Selenocompound metabolism Ribosome biogenesis in eukaryotes 0.72173913 0.716403162 0.808494208 kegg kegg NA NA no no no no no no Sphingolipid metabolism Ribosome biogenesis in eukaryotes -0.687826087 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Ribosome biogenesis in eukaryotes -0.44173913 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Ribosome biogenesis in eukaryotes 0.557391304 0.601778656 0.542857143 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Ribosome biogenesis in eukaryotes 0 0.51284585 0.446332046 kegg kegg NA NA no no no no no no Sulfur metabolism Ribosome biogenesis in eukaryotes 0 0 -0.562934363 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Ribosome biogenesis in eukaryotes 0.606956522 0.807312253 0.716859717 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Ribosome biogenesis in eukaryotes 0.413913043 0 0.45971686 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Ribosome biogenesis in eukaryotes 0.693043478 0.644268775 0.753667954 kegg kegg NA NA no no no no no no Tryptophan metabolism Ribosome biogenesis in eukaryotes 0 0 0.439124839 kegg kegg NA NA no up no no no no Tyrosine metabolism Ribosome biogenesis in eukaryotes 0 0.636363636 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Ribosome biogenesis in eukaryotes 0 0.710474308 0.678764479 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Ribosome biogenesis in eukaryotes 0.46173913 0.690711462 0.600772201 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Ribosome biogenesis in eukaryotes 0.700869565 0.666007905 0.799485199 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism RIG-I-like receptor signaling pathway -0.515652174 -0.584980237 -0.425740026 kegg kegg NA NA no no no no no no Adherens junction RIG-I-like receptor signaling pathway -0.570434783 -0.769762846 -0.537966538 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes RIG-I-like receptor signaling pathway 0 -0.505928854 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" RIG-I-like receptor signaling pathway 0.555652174 0.809288538 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism RIG-I-like receptor signaling pathway 0 0.438735178 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis RIG-I-like receptor signaling pathway 0 -0.415019763 0 kegg kegg NA NA no no no no no no Apelin signaling pathway RIG-I-like receptor signaling pathway 0 -0.708498024 0 kegg kegg NA NA no no no no no no Apoptosis RIG-I-like receptor signaling pathway 0 0.711462451 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism RIG-I-like receptor signaling pathway -0.466086957 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism RIG-I-like receptor signaling pathway 0.484347826 0.801383399 0.524839125 kegg kegg NA NA no up no no no no Arginine biosynthesis RIG-I-like receptor signaling pathway 0.512173913 0.768774704 0 kegg kegg NA NA no no no no no no Autophagy - animal RIG-I-like receptor signaling pathway 0.782608696 0.943675889 0 kegg kegg NA NA no no no no no no Autophagy - other RIG-I-like receptor signaling pathway 0.625217391 0.58201581 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism RIG-I-like receptor signaling pathway -0.41826087 -0.527667984 -0.620592021 kegg kegg NA NA no no no no no no Biosynthesis of amino acids RIG-I-like receptor signaling pathway 0 0.461462451 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors RIG-I-like receptor signaling pathway -0.576521739 -0.442687747 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids RIG-I-like receptor signaling pathway 0 -0.435770751 -0.676705277 kegg kegg NA NA no no no no no no Butanoate metabolism RIG-I-like receptor signaling pathway -0.409565217 -0.778656126 -0.628828829 kegg kegg NA NA no no no no no no cAMP signaling pathway RIG-I-like receptor signaling pathway 0 0.549407115 0.562419562 yes kegg kegg NA NA no up up no no no Cardiac muscle contraction RIG-I-like receptor signaling pathway 0 -0.670948617 0 kegg kegg NA NA no no up no no no Cell cycle RIG-I-like receptor signaling pathway 0 -0.4743083 0 kegg kegg NA NA no no no no no no Cellular senescence RIG-I-like receptor signaling pathway 0 0.468379447 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway RIG-I-like receptor signaling pathway 0.47826087 0.538537549 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway RIG-I-like receptor signaling pathway 0.433913043 0.563241107 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) RIG-I-like receptor signaling pathway -0.523478261 -0.763833992 -0.41003861 kegg kegg NA NA no no no no no no Complement and coagulation cascades RIG-I-like receptor signaling pathway 0 0.442687747 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism RIG-I-like receptor signaling pathway 0 -0.760869565 0 kegg kegg NA NA no no no no no no DNA replication RIG-I-like receptor signaling pathway 0 -0.742094862 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 RIG-I-like receptor signaling pathway 0 -0.818181818 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes RIG-I-like receptor signaling pathway 0 -0.84486166 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance RIG-I-like receptor signaling pathway 0 -0.552371542 0 kegg kegg NA NA no no no no no no ErbB signaling pathway RIG-I-like receptor signaling pathway 0.446086957 0.578063241 0 kegg kegg NA NA no no no no no no Ether lipid metabolism RIG-I-like receptor signaling pathway 0 0 -0.460746461 kegg kegg NA NA no no no no no no Fatty acid biosynthesis RIG-I-like receptor signaling pathway 0.54173913 0.72826087 0 kegg kegg NA NA no no no no no no Fatty acid degradation RIG-I-like receptor signaling pathway 0 0.509881423 0 kegg kegg NA NA no no no no no no Fatty acid elongation RIG-I-like receptor signaling pathway -0.433913043 -0.522727273 -0.652252252 kegg kegg NA NA no no no no no no Focal adhesion RIG-I-like receptor signaling pathway -0.607826087 -0.787549407 -0.604890605 kegg kegg NA NA no up up no no no FoxO signaling pathway RIG-I-like receptor signaling pathway 0.462608696 0.599802372 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism RIG-I-like receptor signaling pathway 0 0.5 0 kegg kegg NA NA no no no no no no Galactose metabolism RIG-I-like receptor signaling pathway 0 0.429841897 0 kegg kegg NA NA no no no no no no Gap junction RIG-I-like receptor signaling pathway -0.47826087 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism RIG-I-like receptor signaling pathway -0.482608696 -0.589920949 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism RIG-I-like receptor signaling pathway 0 0.497035573 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism RIG-I-like receptor signaling pathway 0 0.445652174 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" RIG-I-like receptor signaling pathway -0.549565217 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis RIG-I-like receptor signaling pathway 0 -0.70256917 -0.482625483 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate RIG-I-like receptor signaling pathway 0.508695652 0.833003953 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin RIG-I-like receptor signaling pathway -0.608695652 -0.418972332 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series RIG-I-like receptor signaling pathway -0.407826087 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series RIG-I-like receptor signaling pathway 0 0.486166008 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism RIG-I-like receptor signaling pathway 0 0.77173913 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway RIG-I-like receptor signaling pathway 0 -0.587944664 0 kegg kegg NA NA no no no no no no Hippo signaling pathway RIG-I-like receptor signaling pathway -0.756521739 -0.805335968 -0.616216216 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species RIG-I-like receptor signaling pathway 0.452173913 0.67687747 0 kegg kegg NA NA no no no no no no Histidine metabolism RIG-I-like receptor signaling pathway 0 0 -0.424967825 kegg kegg NA NA no no no no no no Lachnospira RIG-I-like receptor signaling pathway 0 -0.517420327 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Linoleic acid metabolism RIG-I-like receptor signaling pathway 0 -0.433794466 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species RIG-I-like receptor signaling pathway 0 0 -0.481338481 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 RIG-I-like receptor signaling pathway 0 -0.833003953 0 kegg kegg NA NA no no no no no no Mismatch repair RIG-I-like receptor signaling pathway 0 -0.660079051 -0.510682111 kegg kegg NA NA no no no no no no mTOR signaling pathway RIG-I-like receptor signaling pathway 0 -0.523715415 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis RIG-I-like receptor signaling pathway 0 -0.683794466 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway RIG-I-like receptor signaling pathway 0.683478261 0.971343874 0.910939511 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism RIG-I-like receptor signaling pathway 0.512173913 0.720355731 0.402831403 kegg kegg NA NA no no no no no no Nitrogen metabolism RIG-I-like receptor signaling pathway 0.491304348 0.738142292 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway 0.539130435 0.858695652 0 kegg kegg NA NA no no no no no no Non-homologous end-joining RIG-I-like receptor signaling pathway 0 -0.611660079 -0.537709138 kegg kegg NA NA no no no no no no Notch signaling pathway RIG-I-like receptor signaling pathway 0 0.47826087 0 kegg kegg NA NA no no no no no no Nucleotide excision repair RIG-I-like receptor signaling pathway 0 -0.64229249 -0.513256113 kegg kegg NA NA no no no no no no One carbon pool by folate RIG-I-like receptor signaling pathway 0 -0.686758893 0 kegg kegg NA NA no no no no no no Oocyte meiosis RIG-I-like receptor signaling pathway 0 -0.68972332 0 kegg kegg NA NA no no no no no no Osteoclast differentiation RIG-I-like receptor signaling pathway 0.536521739 0.720355731 0.525868726 kegg kegg NA NA no no no no no no Other glycan degradation RIG-I-like receptor signaling pathway 0 0.480237154 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation RIG-I-like receptor signaling pathway 0 -0.683794466 -0.403861004 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis RIG-I-like receptor signaling pathway 0.440869565 0.603754941 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions RIG-I-like receptor signaling pathway -0.572173913 -0.755928854 0 kegg kegg NA NA no no no no no no Peroxisome RIG-I-like receptor signaling pathway 0 0.596837945 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism RIG-I-like receptor signaling pathway -0.732173913 -0.749011858 -0.554440154 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway RIG-I-like receptor signaling pathway 0 0.729249012 0 kegg kegg NA NA no up up no no no Platelet activation RIG-I-like receptor signaling pathway -0.653913043 -0.696640316 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism RIG-I-like receptor signaling pathway -0.452173913 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway RIG-I-like receptor signaling pathway 0.540869565 0.76284585 0.463577864 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis RIG-I-like receptor signaling pathway -0.462608696 -0.562252964 -0.490604891 kegg kegg NA NA no no no no no no Propanoate metabolism RIG-I-like receptor signaling pathway 0 -0.727272727 0 kegg kegg NA NA no no no no no no Proteasome RIG-I-like receptor signaling pathway 0 -0.657114625 0 kegg kegg NA NA no no no no no no Protein export RIG-I-like receptor signaling pathway 0 -0.681818182 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum RIG-I-like receptor signaling pathway 0 -0.60770751 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism RIG-I-like receptor signaling pathway 0 -0.70256917 0 kegg kegg NA NA no no no no no no Pyruvate metabolism RIG-I-like receptor signaling pathway 0 -0.788537549 -0.47979408 kegg kegg NA NA no no no no no no Rap1 signaling pathway RIG-I-like receptor signaling pathway 0 -0.52173913 0 kegg kegg NA NA no no no no no no Ras signaling pathway RIG-I-like receptor signaling pathway 0 -0.7243083 0 yes kegg kegg NA NA no up up no no no Renin-angiotensin system RIG-I-like receptor signaling pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Retinol metabolism RIG-I-like receptor signaling pathway 0 -0.568181818 -0.465379665 kegg kegg NA NA no no no no no no Ribosome RIG-I-like receptor signaling pathway 0 -0.660079051 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes RIG-I-like receptor signaling pathway 0 -0.480237154 0 kegg kegg NA NA no no no no no no RNA degradation RIG-I-like receptor signaling pathway 0 -0.617588933 0 kegg kegg NA NA no no no no no no RNA polymerase RIG-I-like receptor signaling pathway 0 -0.583003953 0 kegg kegg NA NA no no no no no no RNA transport RIG-I-like receptor signaling pathway 0 -0.493083004 0 kegg kegg NA NA no no no no no no Roseburia RIG-I-like receptor signaling pathway -0.448695652 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Sarcina RIG-I-like receptor signaling pathway 0 0.422326513 0 Genus kegg 0.0703 NA no no no no no no SNARE interactions in vesicular transport RIG-I-like receptor signaling pathway 0 0.683794466 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway RIG-I-like receptor signaling pathway 0.425217391 0.471343874 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism RIG-I-like receptor signaling pathway 0 0.590909091 0 kegg kegg NA NA no no no no no no Steroid biosynthesis RIG-I-like receptor signaling pathway -0.411304348 -0.657114625 -0.658944659 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis RIG-I-like receptor signaling pathway -0.449565217 -0.665019763 -0.402574003 kegg kegg NA NA no no no no no no Sulfur metabolism RIG-I-like receptor signaling pathway -0.479130435 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies RIG-I-like receptor signaling pathway 0 -0.572134387 -0.530759331 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism RIG-I-like receptor signaling pathway 0 0.564229249 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway RIG-I-like receptor signaling pathway 0 -0.695652174 0 kegg kegg NA NA no no no no no no Thiamine metabolism RIG-I-like receptor signaling pathway 0 -0.532608696 0 kegg kegg NA NA no no no no no no Tight junction RIG-I-like receptor signaling pathway -0.552173913 -0.65513834 -0.616731017 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway RIG-I-like receptor signaling pathway 0.786086957 0.891304348 0.639124839 yes kegg kegg NA NA no no no no no no Tryptophan metabolism RIG-I-like receptor signaling pathway -0.491304348 -0.661067194 -0.474131274 kegg kegg NA NA no up no no no no Tyrosine metabolism RIG-I-like receptor signaling pathway -0.684347826 -0.81916996 -0.742084942 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis RIG-I-like receptor signaling pathway -0.457391304 -0.605731225 -0.466924067 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" RIG-I-like receptor signaling pathway -0.44173913 -0.722332016 -0.616988417 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis RIG-I-like receptor signaling pathway 0 -0.500988142 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction RIG-I-like receptor signaling pathway 0 -0.708498024 0 kegg kegg NA NA no no no no no no VEGF signaling pathway RIG-I-like receptor signaling pathway 0.448695652 0.585968379 0 kegg kegg NA NA no no no no no no Wnt signaling pathway RIG-I-like receptor signaling pathway 0 -0.669960474 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism RNA degradation -0.412173913 0.718379447 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" RNA degradation 0 -0.881422925 -0.64041184 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism RNA degradation -0.666086957 -0.697628458 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism RNA degradation -0.64173913 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis RNA degradation 0 0.535573123 0.493436293 kegg kegg NA NA no no no no no no Anaerostipes RNA degradation 0 0.434077367 0 butyrate-producing Genus kegg 0.568 NA no no no no no no Antifolate resistance RNA degradation 0 0 0.406949807 kegg kegg NA NA no no no no no no Arachidonic acid metabolism RNA degradation 0 0 -0.666409266 kegg kegg NA NA no no no no no no Arginine and proline metabolism RNA degradation -0.476521739 -0.791501976 -0.442471042 kegg kegg NA NA no up no no no no Arginine biosynthesis RNA degradation -0.473913043 -0.91798419 -0.745945946 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism RNA degradation 0 0.482213439 0.432175032 kegg kegg NA NA no no no no no no beta-Alanine metabolism RNA degradation -0.64173913 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids RNA degradation -0.839130435 -0.835968379 -0.765765766 kegg kegg NA NA no no no no no no Biosynthesis of cofactors RNA degradation 0 0.461462451 -0.517889318 kegg kegg NA NA no no no no no no Butanoate metabolism RNA degradation -0.416521739 0.64229249 0 kegg kegg NA NA no no no no no no Carbon metabolism RNA degradation -0.704347826 0 -0.509137709 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) RNA degradation 0 0.626482213 0.477477477 kegg kegg NA NA no no no no no no Collinsella RNA degradation 0 0 -0.406569338 Genus kegg 0.128 NA no no no no no no Cysteine and methionine metabolism RNA degradation 0 0.635375494 0.483140283 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 RNA degradation 0 0.675889328 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes RNA degradation -0.573913043 0.674901186 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance RNA degradation 0.544347826 0.695652174 0.517374517 kegg kegg NA NA no no no no no no Endocrine resistance RNA degradation 0.406956522 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism RNA degradation 0.751304348 0.571146245 0.505791506 kegg kegg NA NA no no no no no no Fatty acid biosynthesis RNA degradation 0 -0.887351779 0 kegg kegg NA NA no no no no no no Fatty acid degradation RNA degradation -0.56 -0.678853755 0 kegg kegg NA NA no no no no no no Fatty acid elongation RNA degradation -0.452173913 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism RNA degradation -0.649565217 -0.722332016 0 kegg kegg NA NA no no no no no no Folate biosynthesis RNA degradation 0 0.779644269 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism RNA degradation -0.691304348 0 0 kegg kegg NA NA no no no no no no Galactose metabolism RNA degradation -0.677391304 -0.562252964 0 kegg kegg NA NA no no no no no no Glutathione metabolism RNA degradation 0 0.537549407 -0.556756757 kegg kegg NA NA no no no no no no Glycerolipid metabolism RNA degradation 0 0 0.658172458 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism RNA degradation 0 0 0.72998713 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" RNA degradation 0 0 -0.53951094 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis RNA degradation -0.710434783 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate RNA degradation 0 -0.601778656 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin RNA degradation 0 0.651185771 0.563963964 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate RNA degradation 0.633913043 0.592885375 0.457142857 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation RNA degradation 0 -0.473320158 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series RNA degradation 0 0.467391304 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series RNA degradation 0.684347826 0 0.401801802 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism RNA degradation -0.48173913 -0.908102767 -0.705019305 kegg kegg NA NA no no no no no no Inositol phosphate metabolism RNA degradation 0 0 0.601801802 kegg kegg NA NA no no no no no no Lysine degradation RNA degradation 0.507826087 0.523715415 0.879021879 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis RNA degradation 0.71826087 0.531620553 0.826769627 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 RNA degradation -0.429565217 0.614624506 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway RNA degradation 0.948695652 0.898221344 0.91969112 kegg kegg NA NA no no no no no no N-Glycan biosynthesis RNA degradation 0.493043478 0.900197628 0.731531532 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism RNA degradation -0.434782609 -0.904150198 -0.565250965 kegg kegg NA NA no no no no no no Nitrogen metabolism RNA degradation -0.543478261 -0.867588933 -0.701930502 kegg kegg NA NA no no no no no no One carbon pool by folate RNA degradation 0 0.622529644 0.675675676 kegg kegg NA NA no no no no no no Other glycan degradation RNA degradation 0 0 0.496010296 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis RNA degradation 0.588695652 0 0.799227799 kegg kegg NA NA no no no no no no Oxidative phosphorylation RNA degradation 0.626956522 0.65513834 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis RNA degradation 0 -0.836956522 -0.45019305 kegg kegg NA NA no no dn no no no Parabacteroides RNA degradation -0.451304348 0 0 Genus kegg 4.19E-05 NA no up up no no no Paraprevotella RNA degradation 0 0.465347547 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions RNA degradation 0 0.814229249 0.599227799 kegg kegg NA NA no no no no no no Pentose phosphate pathway RNA degradation -0.606956522 -0.798418972 -0.744401544 kegg kegg NA NA no no no no no no Phenylalanine metabolism RNA degradation -0.444347826 0.47826087 0 kegg kegg NA NA no no no no no no Platinum drug resistance RNA degradation 0 0 0.446074646 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism RNA degradation 0 0 -0.541312741 kegg kegg NA NA no no no no no no Propanoate metabolism RNA degradation 0 0.561264822 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism RNA degradation -0.570434783 0.539525692 0 kegg kegg NA NA no no no no no no Pyruvate metabolism RNA degradation 0 0.68972332 0 kegg kegg NA NA no no no no no no Retinol metabolism RNA degradation -0.546086957 0 0 kegg kegg NA NA no no no no no no Ribosome RNA degradation 0.750434783 0.659090909 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes RNA degradation 0.532173913 0.678853755 0.87001287 kegg kegg NA NA no no no no no no RNA transport RNA degradation 0 0.65513834 0.406949807 kegg kegg NA NA no no no no no no Selenocompound metabolism RNA degradation 0.42 0 0.604890605 kegg kegg NA NA no no no no no no Starch and sucrose metabolism RNA degradation -0.656521739 -0.811264822 0 kegg kegg NA NA no no no no no no Steroid biosynthesis RNA degradation 0.486956522 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism RNA degradation 0 0 -0.65019305 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies RNA degradation 0 0.446640316 0.438867439 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism RNA degradation 0 0 0.493693694 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis RNA degradation 0.451304348 0 0.651222651 kegg kegg NA NA no no no no no no Thiamine metabolism RNA degradation 0 0.515810277 0 kegg kegg NA NA no no no no no no Tryptophan metabolism RNA degradation -0.411304348 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism RNA degradation -0.465217391 0.462450593 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis RNA degradation 0 0.457509881 0.421879022 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" RNA degradation 0 0.596837945 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis RNA degradation 0.469565217 0.79743083 0.706048906 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism RNA polymerase 0 0.660079051 0.464350064 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" RNA polymerase 0 -0.662055336 -0.421879022 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis RNA polymerase 0 0.767786561 0.570656371 kegg kegg NA NA no no no no no no Antifolate resistance RNA polymerase 0 0.574110672 0.466409266 kegg kegg NA NA no no no no no no Arginine and proline metabolism RNA polymerase -0.416521739 -0.789525692 -0.559330759 kegg kegg NA NA no up no no no no Arginine biosynthesis RNA polymerase 0 -0.723320158 -0.535392535 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism RNA polymerase 0 0 0.596653797 kegg kegg NA NA no no no no no no Biosynthesis of amino acids RNA polymerase -0.48173913 -0.834980237 -0.592020592 kegg kegg NA NA no no no no no no Biosynthesis of cofactors RNA polymerase 0 0.656126482 0 kegg kegg NA NA no no no no no no Butanoate metabolism RNA polymerase 0 0.677865613 0.593307593 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) RNA polymerase 0 0.66798419 0.693178893 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism RNA polymerase 0 0.688735178 0.594079794 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 RNA polymerase 0 0.666996047 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes RNA polymerase 0 0.51284585 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance RNA polymerase 0.571304348 0.553359684 0.568597169 kegg kegg NA NA no no no no no no Ether lipid metabolism RNA polymerase 0 0.640316206 0.736422136 kegg kegg NA NA no no no no no no Fatty acid biosynthesis RNA polymerase 0 -0.706521739 0 kegg kegg NA NA no no no no no no Fatty acid degradation RNA polymerase 0 -0.420948617 0 kegg kegg NA NA no no no no no no Fatty acid metabolism RNA polymerase 0 -0.491106719 0 kegg kegg NA NA no no no no no no Folate biosynthesis RNA polymerase 0 0.493083004 0 kegg kegg NA NA no no no no no no Glutathione metabolism RNA polymerase 0 0.493083004 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism RNA polymerase 0 0 0.434234234 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism RNA polymerase 0 0 0.572972973 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" RNA polymerase 0 0.493083004 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate RNA polymerase -0.553913043 -0.537549407 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin RNA polymerase 0 0.493083004 0.492664093 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate RNA polymerase 0 0 0.406177606 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation RNA polymerase -0.64173913 -0.59486166 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series RNA polymerase 0 0.595849802 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series RNA polymerase -0.406956522 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis RNA polymerase 0.586956522 0.553359684 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism RNA polymerase 0 -0.746047431 -0.456885457 kegg kegg NA NA no no no no no no Inositol phosphate metabolism RNA polymerase 0 0 0.534105534 kegg kegg NA NA no no no no no no Linoleic acid metabolism RNA polymerase 0 0 0.443758044 kegg kegg NA NA no no no no no no Lysine degradation RNA polymerase 0.596521739 0.60770751 0.607979408 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis RNA polymerase 0 0.469367589 0.568854569 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 RNA polymerase 0 0.57312253 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway RNA polymerase 0.563478261 0.77173913 0.616731017 kegg kegg NA NA no no no no no no N-Glycan biosynthesis RNA polymerase 0.759130435 0.81027668 0.655083655 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism RNA polymerase 0 -0.800395257 -0.503217503 kegg kegg NA NA no no no no no no Nitrogen metabolism RNA polymerase -0.527826087 -0.738142292 -0.639382239 kegg kegg NA NA no no no no no no One carbon pool by folate RNA polymerase 0.559130435 0.816205534 0.745431145 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis RNA polymerase 0.682608696 0.619565217 0.622136422 kegg kegg NA NA no no no no no no Oxidative phosphorylation RNA polymerase 0 0.528656126 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis RNA polymerase 0 -0.672924901 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions RNA polymerase 0 0.792490119 0.556756757 kegg kegg NA NA no no no no no no Pentose phosphate pathway RNA polymerase -0.750434783 -0.880434783 -0.53951094 kegg kegg NA NA no no no no no no Phenylalanine metabolism RNA polymerase 0 0.541501976 0 kegg kegg NA NA no no no no no no Platinum drug resistance RNA polymerase 0.69826087 0.419960474 0.438867439 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism RNA polymerase 0 0.443675889 0 kegg kegg NA NA no no no no no no Propanoate metabolism RNA polymerase 0 0.60770751 0.584298584 kegg kegg NA NA no no no no no no Purine metabolism RNA polymerase 0 0.564229249 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism RNA polymerase 0 0.641304348 0 kegg kegg NA NA no no no no no no Pyruvate metabolism RNA polymerase 0 0.725296443 0.527155727 kegg kegg NA NA no no no no no no Retinol metabolism RNA polymerase 0 0.56027668 0.627284427 kegg kegg NA NA no no no no no no Ribosome RNA polymerase 0.529565217 0.52173913 0.469240669 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes RNA polymerase 0.882608696 0.950592885 0.769369369 kegg kegg NA NA no no no no no no RNA degradation RNA polymerase 0.572173913 0.82312253 0.658172458 kegg kegg NA NA no no no no no no RNA transport RNA polymerase 0.513913043 0.514822134 0.405148005 kegg kegg NA NA no no no no no no Selenocompound metabolism RNA polymerase 0.68 0.537549407 0.641441441 kegg kegg NA NA no no no no no no Sphingolipid metabolism RNA polymerase -0.685217391 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism RNA polymerase -0.533913043 -0.613636364 0 kegg kegg NA NA no no no no no no Steroid biosynthesis RNA polymerase 0.653043478 0.580039526 0.66975547 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis RNA polymerase 0 0.489130435 0.466666667 kegg kegg NA NA no no no no no no Sulfur metabolism RNA polymerase 0 0 -0.408494208 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies RNA polymerase 0.440869565 0.746047431 0.670527671 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism RNA polymerase 0.410434783 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis RNA polymerase 0.682608696 0.559288538 0.74002574 kegg kegg NA NA no no no no no no Thiamine metabolism RNA polymerase 0 0.501976285 0 kegg kegg NA NA no no no no no no Tryptophan metabolism RNA polymerase 0 0 0.510682111 kegg kegg NA NA no up no no no no Tyrosine metabolism RNA polymerase 0 0.633399209 0.42033462 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis RNA polymerase 0 0.646245059 0.746460746 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" RNA polymerase 0 0.694664032 0.651737452 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis RNA polymerase 0.695652174 0.687747036 0.586357786 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism RNA transport 0 0.418972332 0 kegg kegg NA NA no no no no no no ABC transporters RNA transport 0.549565217 -0.444664032 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" RNA transport 0 -0.531620553 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism RNA transport 0 -0.711462451 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism RNA transport 0.408695652 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis RNA transport 0.566956522 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism RNA transport 0 -0.538537549 0 kegg kegg NA NA no up no no no no Arginine biosynthesis RNA transport 0 -0.502964427 0 kegg kegg NA NA no no no no no no Bacteroides RNA transport 0 0.501976285 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Butanoate metabolism RNA transport 0.490434783 0.588932806 0.610810811 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) RNA transport 0 0.558300395 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism RNA transport 0.64173913 0.752964427 0.701415701 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 RNA transport 0 0.53458498 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes RNA transport 0 0.552371542 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance RNA transport 0.52 0.950592885 0.753667954 kegg kegg NA NA no no no no no no Fatty acid biosynthesis RNA transport 0 -0.533596838 0 kegg kegg NA NA no no no no no no Fatty acid elongation RNA transport 0 0 0.43011583 kegg kegg NA NA no no no no no no Folate biosynthesis RNA transport 0 0.416996047 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism RNA transport 0 -0.517786561 0 kegg kegg NA NA no no no no no no Galactose metabolism RNA transport 0 -0.549407115 0 kegg kegg NA NA no no no no no no Glutathione metabolism RNA transport 0 0.513833992 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism RNA transport 0 -0.549407115 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism RNA transport 0 -0.438735178 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis RNA transport 0.489565217 0.711462451 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate RNA transport 0 -0.640316206 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation RNA transport -0.433043478 -0.526679842 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series RNA transport 0 -0.423913043 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis RNA transport 0.520869565 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism RNA transport 0 -0.45256917 0 kegg kegg NA NA no no no no no no Lysine degradation RNA transport 0.566956522 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 RNA transport 0 0.48715415 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis RNA transport 0.546086957 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis RNA transport 0 0.545454545 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism RNA transport 0 -0.644268775 0 kegg kegg NA NA no no no no no no Nitrogen metabolism RNA transport 0 -0.470355731 0 kegg kegg NA NA no no no no no no One carbon pool by folate RNA transport 0.445217391 0 0 kegg kegg NA NA no no no no no no Other glycan degradation RNA transport 0.42 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation RNA transport 0 0.543478261 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis RNA transport 0 -0.672924901 0 kegg kegg NA NA no no dn no no no Parabacteroides RNA transport 0 0 -0.525516444 Genus kegg 4.19E-05 NA no up up no no no Pentose and glucuronate interconversions RNA transport 0.405217391 0.559288538 0.409266409 kegg kegg NA NA no no no no no no Pentose phosphate pathway RNA transport 0 -0.429841897 0 kegg kegg NA NA no no no no no no Platinum drug resistance RNA transport 0.405217391 0 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis RNA transport 0.432173913 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism RNA transport 0.634782609 0.767786561 0.697297297 kegg kegg NA NA no no no no no no Pyruvate metabolism RNA transport 0.575652174 0.7756917 0.554697555 kegg kegg NA NA no no no no no no Retinol metabolism RNA transport 0.43826087 0 0 kegg kegg NA NA no no no no no no Ribosome RNA transport 0 0.817193676 0.61003861 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes RNA transport 0.56 0 0.41003861 kegg kegg NA NA no no no no no no Roseburia RNA transport -0.50173913 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Sphingolipid metabolism RNA transport -0.530434783 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism RNA transport 0 -0.633399209 -0.543371943 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies RNA transport 0.48173913 0 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism RNA transport 0 -0.421936759 0 kegg kegg NA NA no no no no no no Thiamine metabolism RNA transport 0.567826087 0.736166008 0 kegg kegg NA NA no no no no no no Tryptophan metabolism RNA transport 0 0 0.419305019 kegg kegg NA NA no up no no no no "Valine, leucine and isoleucine degradation" RNA transport 0.497391304 0 0.410553411 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis RNA transport 0.523478261 0.476284585 0 kegg kegg NA NA no no no no no no Collinsella Roseburia 0 0.621778448 0 butyrate-producing Genus Genus 0.128 0.495 no no no no no no Coprococcus Roseburia 0 0.709618544 0 butyrate-producing butyrate-producing Genus Genus 0.612 0.495 no no no no no no Methanosphaera Roseburia 0 -0.42081542 0 butyrate-producing Genus Genus 0.0703 0.495 no no no no no no Anaerotruncus Ruminococcus 0 -0.426734202 0 acetate-producing Genus Genus 0.904 0.335 no no no no no no 2-Oxocarboxylic acid metabolism Salivary secretion 0 0 -0.505534106 kegg kegg NA NA no no no no no no ABC transporters Salivary secretion -0.727826087 0 -0.556756757 kegg kegg NA NA no up up no no no Adherens junction Salivary secretion 0 0.592885375 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Salivary secretion 0 -0.462450593 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Salivary secretion 0.497391304 0 0 kegg kegg NA NA no no up no no no Aldosterone synthesis and secretion Salivary secretion 0.587826087 0 0.435521236 kegg kegg NA NA no up up no no no Alistipes Salivary secretion 0 -0.43487008 0 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism Salivary secretion -0.411304348 0 -0.415958816 kegg kegg NA NA no no no no no no AMPK signaling pathway Salivary secretion 0 0 0.458687259 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Salivary secretion 0 0 -0.565250965 kegg kegg NA NA no no no no no no Autophagy - animal Salivary secretion 0 -0.518774704 0 kegg kegg NA NA no no no no no no Autophagy - other Salivary secretion -0.427826087 -0.640316206 0 kegg kegg NA NA no no no no no no Base excision repair Salivary secretion -0.480869565 0 0 kegg kegg NA NA no no no no no no Butyricicoccus Salivary secretion -0.409204996 0 0 butyrate-producing Genus kegg 0.852 NA no no no no no no C-type lectin receptor signaling pathway Salivary secretion 0 -0.434782609 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Salivary secretion 0.466956522 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Salivary secretion 0 0 0.408751609 yes kegg kegg NA NA no up up no no no Circadian entrainment Salivary secretion 0.67826087 0.780632411 0.718918919 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Salivary secretion 0 0 -0.536679537 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Salivary secretion 0.494782609 0 0.548005148 kegg kegg NA NA no no up no no no Cushing syndrome Salivary secretion 0.427826087 0 0 kegg kegg NA NA no no up no no no DNA replication Salivary secretion -0.407826087 0 -0.51994852 kegg kegg NA NA no no no no no no Dopaminergic synapse Salivary secretion 0 0.633399209 0 kegg kegg NA NA no up no no no no Drug metabolism - other enzymes Salivary secretion 0 0 -0.427799228 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Salivary secretion 0.706956522 0.497035573 0.655598456 kegg kegg NA NA no no no no no no Endocrine resistance Salivary secretion 0.412173913 0 0.55032175 kegg kegg NA NA no no no no no no Estrogen signaling pathway Salivary secretion 0 0 0.52046332 kegg kegg NA NA no no no no no no Ether lipid metabolism Salivary secretion 0 0 -0.455598456 kegg kegg NA NA no no no no no no Fatty acid degradation Salivary secretion 0 -0.41798419 0 kegg kegg NA NA no no no no no no Ferroptosis Salivary secretion 0.488695652 0 0.417245817 kegg kegg NA NA no no no no no no Focal adhesion Salivary secretion 0.416521739 0.550395257 0 kegg kegg NA NA no up up no no no Folate biosynthesis Salivary secretion -0.449565217 0 -0.535135135 kegg kegg NA NA no no no no no no Galactose metabolism Salivary secretion 0 0 -0.466666667 kegg kegg NA NA no no no no no no Gap junction Salivary secretion 0.770434783 0 0.649163449 kegg kegg NA NA no no no no no no Glutamatergic synapse Salivary secretion 0.833913043 0 0.717631918 kegg kegg NA NA no up up no no no Glycerolipid metabolism Salivary secretion -0.542608696 0 -0.636293436 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Salivary secretion -0.486956522 0 -0.540540541 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Salivary secretion 0 0 0.422393822 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Salivary secretion 0 0 -0.678249678 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Salivary secretion 0 0 -0.406177606 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Salivary secretion 0 0 -0.562676963 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - globo and isoglobo series Salivary secretion 0.435652174 0 0 kegg kegg NA NA no no no no no no GnRH secretion Salivary secretion 0 0 -0.402831403 kegg kegg NA NA no up up no no no GnRH signaling pathway Salivary secretion 0.656521739 0 0.567824968 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Salivary secretion 0 0 0.438610039 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Salivary secretion 0 0 -0.447619048 kegg kegg NA NA no no no no no no Hippo signaling pathway Salivary secretion 0 0.495059289 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Salivary secretion 0 0 -0.42033462 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Salivary secretion 0.585217391 0.584980237 0.438867439 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Salivary secretion -0.584347826 0 -0.467953668 kegg kegg NA NA no no no no no no Insulin resistance Salivary secretion -0.473043478 -0.483201581 0 kegg kegg NA NA no no no no no no Insulin secretion Salivary secretion 0.451304348 0 0.518404118 yes kegg kegg NA NA no up up no no no JAK-STAT signaling pathway Salivary secretion 0 -0.459486166 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Salivary secretion 0.433043478 0 0 kegg kegg NA NA no no no no no no Long-term depression Salivary secretion 0.703478261 0 0.675160875 kegg kegg NA NA no no no no no no Lysine degradation Salivary secretion -0.586956522 0 -0.50990991 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Salivary secretion 0 0 -0.507335907 kegg kegg NA NA no no no no no no MAPK signaling pathway Salivary secretion 0 -0.548418972 -0.47001287 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Salivary secretion 0 0 -0.470785071 kegg kegg NA NA no up no no no no Melanogenesis Salivary secretion 0.628695652 0.532608696 0.51016731 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Salivary secretion 0 -0.578063241 0 kegg kegg NA NA no no no no no no Necroptosis Salivary secretion 0 0 0.44967825 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Salivary secretion 0 -0.482213439 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Salivary secretion -0.696521739 -0.502964427 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Salivary secretion 0 -0.480237154 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Salivary secretion 0 0.428853755 0 kegg kegg NA NA no no no no no no Notch signaling pathway Salivary secretion 0 0 -0.614929215 kegg kegg NA NA no no no no no no One carbon pool by folate Salivary secretion 0 0 -0.433462033 kegg kegg NA NA no no no no no no Oscillospira Salivary secretion 0 -0.493083004 0 LPS-producing Genus kegg 0.62 NA no no no no no no Other glycan degradation Salivary secretion -0.535652174 0 -0.454826255 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Salivary secretion -0.412173913 0 -0.453796654 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Salivary secretion 0.644347826 0.539525692 0.731274131 kegg kegg NA NA no up up no no no Oxytocin signaling pathway Salivary secretion 0.433043478 0.714426877 0.568082368 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Salivary secretion 0 0 0.486486486 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Salivary secretion 0 0 -0.428571429 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Salivary secretion 0 0 -0.433462033 kegg kegg NA NA no no no no no no Phototransduction Salivary secretion 0.476521739 0 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Salivary secretion -0.562608696 0 0 yes kegg kegg NA NA no up up no no no Platelet activation Salivary secretion 0.554782609 0.691699605 0 kegg kegg NA NA no no no no no no Platinum drug resistance Salivary secretion 0 -0.422924901 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Salivary secretion 0 -0.523715415 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Salivary secretion 0 -0.456521739 -0.416988417 kegg kegg NA NA no no no no no no Proteasome Salivary secretion 0 0 -0.518146718 kegg kegg NA NA no no no no no no Pyrimidine metabolism Salivary secretion 0 0 -0.43037323 kegg kegg NA NA no no no no no no Rap1 signaling pathway Salivary secretion 0.47826087 0.681818182 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Salivary secretion 0 0.419960474 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Salivary secretion 0.659130435 0.476284585 0.668725869 kegg kegg NA NA no no no no no no Renin secretion Salivary secretion 0.722608696 0.648221344 0.758558559 kegg kegg NA NA no no no no no no Retinol metabolism Salivary secretion 0 0 -0.406949807 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Salivary secretion 0 0.498023715 0 kegg kegg NA NA no no up no no no Ribosome biogenesis in eukaryotes Salivary secretion 0 0 -0.427027027 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Salivary secretion -0.468695652 -0.576086957 0 kegg kegg NA NA no no no no no no RNA degradation Salivary secretion 0 0 -0.444015444 kegg kegg NA NA no no no no no no RNA polymerase Salivary secretion 0 0 -0.506821107 kegg kegg NA NA no no no no no no RNA transport Salivary secretion -0.446956522 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Salivary secretion -0.545217391 0 -0.477992278 kegg kegg NA NA no no no no no no Serotonergic synapse Salivary secretion 0.548695652 0.501976285 0.635006435 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Salivary secretion -0.690434783 -0.469367589 0 kegg kegg NA NA no no no no no no Spliceosome Salivary secretion -0.453043478 -0.503952569 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Salivary secretion 0 0 -0.597683398 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Salivary secretion -0.486956522 -0.765810277 0 kegg kegg NA NA no no no no no no Taste transduction Salivary secretion 0 0 -0.593564994 kegg kegg NA NA no no up no no no Terpenoid backbone biosynthesis Salivary secretion 0 0 -0.589446589 kegg kegg NA NA no no no no no no Th17 cell differentiation Salivary secretion 0 -0.485177866 0 kegg kegg NA NA no no no no no no Thiamine metabolism Salivary secretion -0.506956522 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Salivary secretion 0.408695652 0.516798419 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Salivary secretion 0.552173913 0 0.559073359 kegg kegg NA NA no no no no no no Tight junction Salivary secretion 0 0.494071146 0 kegg kegg NA NA no no no no no no TNF signaling pathway Salivary secretion 0 -0.453557312 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Salivary secretion 0 -0.420948617 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Salivary secretion 0 0 -0.406949807 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Salivary secretion 0 0 -0.417503218 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Salivary secretion 0.465217391 0.599802372 0.568854569 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Salivary secretion 0.631304348 0.617588933 0.634234234 kegg kegg NA NA no no no no no no Wnt signaling pathway Salivary secretion 0 0 -0.483140283 kegg kegg NA NA no no no no no no ABC transporters Salmonella infection 0 0 -0.451737452 kegg kegg NA NA no up up no no no Adherens junction Salmonella infection 0 0 0.645817246 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Salmonella infection -0.431304348 0 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Salmonella infection 0 -0.60770751 0 kegg kegg NA NA no no up no no no Aldosterone synthesis and secretion Salmonella infection -0.613043478 -0.816205534 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Salmonella infection 0.586956522 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Salmonella infection 0.48 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Salmonella infection -0.517391304 -0.7243083 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Salmonella infection -0.487826087 -0.652173913 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Salmonella infection -0.444347826 -0.451581028 0 kegg kegg NA NA no no no no no no Antifolate resistance Salmonella infection 0 -0.41798419 -0.446589447 kegg kegg NA NA no no no no no no Antigen processing and presentation Salmonella infection 0.568695652 0.543478261 0.416473616 kegg kegg NA NA no no no no no no Apoptosis Salmonella infection 0.56173913 0.509881423 0.584298584 kegg kegg NA NA no no no no no no Autophagy - other Salmonella infection 0 0 -0.453796654 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Salmonella infection 0.491304348 0 0.756756757 kegg kegg NA NA no no no no no no Basal transcription factors Salmonella infection 0 -0.517786561 -0.496267696 kegg kegg NA NA no no no no no no Base excision repair Salmonella infection 0 -0.482213439 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Salmonella infection 0.465217391 0.415019763 0.436550837 kegg kegg NA NA no no no no no no Bile secretion Salmonella infection 0 -0.586956522 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Salmonella infection 0.572173913 0.735177866 0.644787645 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Salmonella infection 0 -0.580039526 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Salmonella infection 0.460869565 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Salmonella infection -0.544347826 -0.574110672 0 kegg kegg NA NA no up up no no no Carbon metabolism Salmonella infection 0.58 0.78458498 0.692921493 kegg kegg NA NA no no no no no no Cell adhesion molecules Salmonella infection 0.413043478 0.804347826 0.537451737 kegg kegg NA NA no no no no no no Cell cycle Salmonella infection 0 -0.558300395 -0.445302445 kegg kegg NA NA no no no no no no Cellular senescence Salmonella infection 0 0.570158103 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Salmonella infection 0 0.617588933 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Salmonella infection 0 0.432806324 0 kegg kegg NA NA no no no no no no Cholesterol metabolism Salmonella infection 0 0.802371542 0 yes kegg kegg NA NA no no up no no no Circadian rhythm Salmonella infection 0 -0.706521739 -0.627541828 kegg kegg NA NA no no no no no no Clostridium Salmonella infection 0 0.415672633 0 Genus kegg 0.925 NA no no no no no no Cocaine addiction Salmonella infection -0.632173913 -0.801383399 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Salmonella infection 0.527826087 0.574110672 0.688545689 kegg kegg NA NA no no no no no no Coprococcus Salmonella infection 0 0 0.414569793 butyrate-producing Genus kegg 0.612 NA no no no no no no Cortisol synthesis and secretion Salmonella infection -0.667826087 -0.880434783 0 kegg kegg NA NA no no up no no no Cushing syndrome Salmonella infection -0.570434783 -0.920948617 0 kegg kegg NA NA no no up no no no Cytokine-cytokine receptor interaction Salmonella infection 0 0 0.548777349 kegg kegg NA NA no no no no no no Dopaminergic synapse Salmonella infection 0 -0.595849802 0 kegg kegg NA NA no up no no no no Drug metabolism - other enzymes Salmonella infection 0.493043478 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Salmonella infection -0.491304348 -0.68083004 0 kegg kegg NA NA no no no no no no Endocrine resistance Salmonella infection -0.630434783 -0.825098814 0 kegg kegg NA NA no no no no no no Endocytosis Salmonella infection 0.46 0.755928854 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Salmonella infection 0 0.56027668 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Salmonella infection -0.52173913 -0.601778656 -0.412612613 kegg kegg NA NA no no no no no no Eubacterium Salmonella infection 0 0 -0.423323391 Genus kegg 0.0692 NA no no no no no no Fanconi anemia pathway Salmonella infection 0 -0.43972332 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Salmonella infection 0 0.494071146 0 yes kegg kegg NA NA no up up no no no Fatty acid degradation Salmonella infection 0.453043478 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Salmonella infection 0.533043478 0.481225296 0.425997426 kegg kegg NA NA no no no no no no Fatty acid metabolism Salmonella infection 0.492173913 0.445652174 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Salmonella infection 0.806086957 0.684782609 0.631402831 kegg kegg NA NA no no no no no no Focal adhesion Salmonella infection 0.422608696 0 0.653281853 kegg kegg NA NA no up up no no no Galactose metabolism Salmonella infection 0.426086957 0 0 kegg kegg NA NA no no no no no no Gap junction Salmonella infection 0 -0.5 0 kegg kegg NA NA no no no no no no Gastric acid secretion Salmonella infection 0 0 0.534362934 kegg kegg NA NA no no no no no no Glucagon signaling pathway Salmonella infection -0.43826087 -0.726284585 -0.422393822 kegg kegg NA NA no no no no no no Glutathione metabolism Salmonella infection 0 -0.45256917 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Salmonella infection -0.486086957 -0.470355731 -0.543886744 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Salmonella infection 0 -0.592885375 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Salmonella infection 0.513913043 0 0.504247104 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Salmonella infection -0.609565217 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Salmonella infection 0 0.610671937 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Salmonella infection -0.484347826 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Salmonella infection 0 -0.586956522 -0.43011583 kegg kegg NA NA no no no no no no GnRH signaling pathway Salmonella infection -0.604347826 -0.837944664 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Salmonella infection -0.528695652 -0.589920949 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Salmonella infection -0.409565217 -0.414031621 -0.473616474 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Salmonella infection 0 0 0.465637066 kegg kegg NA NA no no no no no no Hippo signaling pathway Salmonella infection 0 0 0.575546976 kegg kegg NA NA no no no no no no Huntington disease Salmonella infection -0.472173913 -0.421936759 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Salmonella infection 0 0.590909091 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Salmonella infection -0.410434783 -0.623517787 0 kegg kegg NA NA no no no no no no Insulin resistance Salmonella infection 0 0 -0.625740026 kegg kegg NA NA no no no no no no Insulin secretion Salmonella infection -0.699130435 -0.880434783 0 yes kegg kegg NA NA no up up no no no Leukocyte transendothelial migration Salmonella infection 0.465217391 0.492094862 0.886743887 kegg kegg NA NA no no no no no no Long-term depression Salmonella infection -0.529565217 -0.467391304 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Salmonella infection -0.709565217 -0.53458498 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Salmonella infection 0.405217391 0.549407115 0 kegg kegg NA NA no no no no no no Lysine degradation Salmonella infection 0 -0.535573123 -0.572715573 kegg kegg NA NA no no no no no no Lysosome Salmonella infection 0 0.733201581 0.405405405 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Salmonella infection -0.571304348 -0.453557312 -0.544916345 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Salmonella infection -0.54 -0.45256917 0 kegg kegg NA NA no up no no no no Melanogenesis Salmonella infection 0 -0.619565217 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Salmonella infection 0.414782609 0 0 kegg kegg NA NA no no no no no no Mineral absorption Salmonella infection -0.56173913 -0.414031621 0 kegg kegg NA NA no no no no no no Mitophagy - animal Salmonella infection -0.646956522 -0.485177866 0 kegg kegg NA NA no no no no no no Morphine addiction Salmonella infection -0.439130435 -0.683794466 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Salmonella infection -0.510434783 -0.621541502 -0.592277992 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Salmonella infection 0.506086957 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Salmonella infection 0.516521739 0.677865613 0 kegg kegg NA NA no no no no no no Necroptosis Salmonella infection -0.540869565 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Salmonella infection 0.744347826 0.721343874 0.562934363 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Salmonella infection 0.666086957 0.639328063 0.686229086 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Salmonella infection 0.442608696 0 0 kegg kegg NA NA no no no no no no Nicotine addiction Salmonella infection 0 -0.450592885 0 kegg kegg NA NA no up up no no no NOD-like receptor signaling pathway Salmonella infection 0.611304348 0.441699605 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Salmonella infection -0.427826087 -0.416996047 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Salmonella infection 0.539130435 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Salmonella infection 0 0 -0.405148005 kegg kegg NA NA no no no no no no Odoribacter Salmonella infection 0 0.526004585 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Olfactory transduction Salmonella infection 0.548695652 0.600790514 0.506306306 kegg kegg NA NA no no no no no no Oscillospira Salmonella infection -0.429565217 0 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Salmonella infection 0.574782609 0.568181818 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Salmonella infection -0.523478261 -0.696640316 -0.585585586 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Salmonella infection 0 -0.639328063 0 kegg kegg NA NA no up up no no no Oxytocin signaling pathway Salmonella infection 0.405217391 0 0.69009009 kegg kegg NA NA no no no no no no p53 signaling pathway Salmonella infection -0.470434783 -0.559288538 -0.686743887 kegg kegg NA NA no no no no no no Pancreatic secretion Salmonella infection -0.468695652 -0.57312253 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Salmonella infection 0.525217391 0 0 kegg kegg NA NA no no dn no no no Paraprevotella Salmonella infection 0.476704646 0 0 Genus kegg 0.118 NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Salmonella infection -0.520869565 -0.546442688 0 kegg kegg NA NA no no no no no no Parkinson disease Salmonella infection -0.592173913 -0.43972332 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Salmonella infection 0.773043478 0.882411067 0.855341055 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Salmonella infection -0.609565217 -0.467391304 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Salmonella infection 0.48173913 0.7243083 0.44993565 kegg kegg NA NA no no no no no no Peroxisome Salmonella infection 0.434782609 0.447628458 0 kegg kegg NA NA no no no no no no Phagosome Salmonella infection 0.44173913 0.816205534 0.656628057 kegg kegg NA NA no no no no no no Phenylalanine metabolism Salmonella infection 0 0 0.422908623 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Salmonella infection -0.451304348 -0.488142292 -0.525096525 kegg kegg NA NA no no no no no no Platelet activation Salmonella infection 0 0 0.675933076 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Salmonella infection 0 -0.498023715 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Salmonella infection 0 0.550395257 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Salmonella infection 0 0 0.521750322 kegg kegg NA NA no no no no no no Protein digestion and absorption Salmonella infection 0 0.440711462 0 yes kegg kegg NA NA no up up no no no Purine metabolism Salmonella infection -0.452173913 -0.596837945 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Salmonella infection 0 0 -0.483655084 kegg kegg NA NA no no no no no no Rap1 signaling pathway Salmonella infection 0 0 0.656628057 kegg kegg NA NA no no no no no no Ras signaling pathway Salmonella infection 0 0 -0.443758044 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Salmonella infection 0.58 0 0.545688546 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Salmonella infection 0 -0.694664032 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Salmonella infection -0.506086957 0 0 kegg kegg NA NA no no no no no no Renin secretion Salmonella infection 0 -0.496047431 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Salmonella infection 0.597391304 0.663043478 0.43989704 kegg kegg NA NA no no no no no no Retinol metabolism Salmonella infection 0.611304348 0 0 kegg kegg NA NA no no no no no no Ribosome Salmonella infection -0.615652174 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Salmonella infection 0 -0.482213439 -0.452252252 kegg kegg NA NA no no no no no no RNA degradation Salmonella infection -0.502608696 -0.447628458 -0.472586873 kegg kegg NA NA no no no no no no RNA polymerase Salmonella infection -0.433913043 -0.532608696 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Salmonella infection 0 -0.466403162 -0.448648649 kegg kegg NA NA no no no no no no Shigellosis Salmonella infection -0.419130435 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Salmonella infection 0 -0.5256917 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Salmonella infection 0 0.502964427 0 kegg kegg NA NA no no no no no no Spliceosome Salmonella infection 0 -0.418972332 -0.416731017 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Salmonella infection 0.553043478 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Salmonella infection 0.476521739 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Salmonella infection 0 0.678853755 0 kegg kegg NA NA no up up no no no Taurine and hypotaurine metabolism Salmonella infection 0 -0.467391304 -0.485714286 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Salmonella infection 0 0.497035573 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Salmonella infection 0 0.494071146 0 kegg kegg NA NA no no no no no no Thermogenesis Salmonella infection -0.431304348 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Salmonella infection -0.576521739 -0.755928854 0 kegg kegg NA NA no no no no no no Tight junction Salmonella infection 0 0 0.56962677 kegg kegg NA NA no no no no no no Type I diabetes mellitus Salmonella infection 0 0.704545455 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Salmonella infection -0.663478261 -0.556324111 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Salmonella infection -0.469565217 0 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Salmonella infection -0.479130435 -0.626482213 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Salmonella infection 0 0 0.553410553 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Salmonella infection -0.469565217 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Salmonella infection 0 -0.470355731 -0.447876448 kegg kegg NA NA no no no no no no 14:0/16:0-PC+blood Sarcosine+blood 0 0 0.442735043 serum_phospholipids serum_choline 0.0358 5.06E-05 no up no up up no 14:0/18:0-PC+blood Sarcosine+blood 0 0 0.468034188 serum_phospholipids serum_choline 0.00289 5.06E-05 up up no up up no 16:0-LPC+blood Sarcosine+blood 0 0.536764706 0 serum_phospholipids serum_choline 0.00456 5.06E-05 up up no up up no 16:0-LPE+blood Sarcosine+blood 0.535338346 0 0.474188034 serum_phospholipids serum_choline 0.0711 5.06E-05 up up no up up no 16:0/16:1-PC+blood Sarcosine+blood 0 0 0.469401709 serum_phospholipids serum_choline 0.00283 5.06E-05 up up no up up no 16:0/16:1-PI+blood Sarcosine+blood 0 0 0.540512821 serum_phospholipids serum_choline 0.262 5.06E-05 no no no up up no 16:0/18:2-PI+blood Sarcosine+blood 0 0 0.545982906 serum_phospholipids serum_choline 0.269 5.06E-05 no no no up up no 16:0/18:3-PC+blood Sarcosine+blood 0 0 0.424273504 serum_phospholipids serum_choline 0.00216 5.06E-05 no up up up up no 16:0/20:3-PC+blood Sarcosine+blood 0 0 0.437948718 serum_phospholipids serum_choline 5.43E-06 5.06E-05 no up up up up no 16:0/20:4-PI+blood Sarcosine+blood 0 0 0.534358974 serum_phospholipids serum_choline 0.558 5.06E-05 no no no up up no 16:1/16:1-PC+blood Sarcosine+blood -0.446616541 0 0 serum_phospholipids serum_choline 0.0177 5.06E-05 no no up up up no 18:0/20:3-PC+blood Sarcosine+blood 0 0 0.624615385 serum_phospholipids serum_choline 0.0682 5.06E-05 no up no up up no 18:0/22:6-PA+blood Sarcosine+blood -0.580451128 0 0 serum_phospholipids serum_choline 0.22 5.06E-05 no no no up up no 18:1/16:0-PI+blood Sarcosine+blood 0 0 0.446153846 serum_phospholipids serum_choline 0.793 5.06E-05 no no no up up no 18:1/18:0-PS+blood Sarcosine+blood -0.44962406 -0.490196078 0 serum_phospholipids serum_choline 0.193 5.06E-05 no no no up up no 18:1/18:1-PC+blood Sarcosine+blood 0 0 0.467350427 serum_phospholipids serum_choline 1.34E-05 5.06E-05 no up up up up no 18:2-LPA+blood Sarcosine+blood -0.538345865 0 0 serum_phospholipids serum_choline 0.00684 5.06E-05 dn no up up up no 18:3n3+blood Sarcosine+blood 0 0 -0.417435897 serum_fattyacid serum_choline 0.291 5.06E-05 no no no up up no 18:3n6+blood Sarcosine+blood 0 0 0.570598291 serum_fattyacid serum_choline 0.0463 5.06E-05 up no dn up up no 20:0-LPC+blood Sarcosine+blood 0 -0.5 0 serum_phospholipids serum_choline 0.199 5.06E-05 no no no up up no 20:0-LPE+blood Sarcosine+blood 0 -0.600490196 0 serum_phospholipids serum_choline 0.0615 5.06E-05 no no up up up no 20:0+blood Sarcosine+blood 0 -0.664215686 0.443418803 yes serum_fattyacid serum_choline 0.000278 5.06E-05 dn no up up up no 20:1-LPE+blood Sarcosine+blood 0 -0.558823529 0 serum_phospholipids serum_choline 0.465 5.06E-05 no no no up up no 20:2-LPE+blood Sarcosine+blood -0.482706767 -0.715686275 0 serum_phospholipids serum_choline 0.177 5.06E-05 no no no up up no 20:2/18:0-PC+blood Sarcosine+blood 0 0 0.620512821 serum_phospholipids serum_choline 0.0427 5.06E-05 no up no up up no 20:3-LPC+blood Sarcosine+blood 0 0 0.707350427 serum_phospholipids serum_choline 0.0292 5.06E-05 no up no up up no 20:3-LPE+blood Sarcosine+blood 0 0 0.498119658 serum_phospholipids serum_choline 0.084 5.06E-05 no up no up up no 20:3n6+blood Sarcosine+blood 0 0 0.612307692 serum_fattyacid serum_choline 0.0884 5.06E-05 up no no up up no 22:2-LPA+blood Sarcosine+blood 0 0 0.478290598 serum_phospholipids serum_choline 0.0443 5.06E-05 dn no no up up no 24:0+blood Sarcosine+blood 0 -0.509803922 0 serum_fattyacid serum_choline 0.034 5.06E-05 dn no up up up no ACA+stool Sarcosine+blood 0 0 0.445536443 stool_bileacids serum_choline 0.417 5.06E-05 no no no up up no acetic acid C2+blood Sarcosine+blood 0 0 -0.464615385 serum_scfa serum_choline 0.000193 5.06E-05 up dn no up up no Alistipes Sarcosine+blood 0 -0.548130085 0 Genus serum_choline 0.0114 5.06E-05 no up no up up no Allograft rejection Sarcosine+blood 0 0 0.458461538 kegg serum_choline NA 5.06E-05 no no no up up no Apoptosis Sarcosine+blood 0.538596491 0 0 kegg serum_choline NA 5.06E-05 no no no up up no Autoimmune thyroid disease Sarcosine+blood 0 0 0.458461538 kegg serum_choline NA 5.06E-05 no no no up up no Bifidobacterium Sarcosine+blood -0.585182441 0 0 acetate-producing Genus serum_choline 0.105 5.06E-05 no dn no up up no Butyricimonas Sarcosine+blood -0.497106714 0 0 butyrate-producing Genus serum_choline 0.17 5.06E-05 no no no up up no C-type lectin receptor signaling pathway Sarcosine+blood 0 0 0.413076923 kegg serum_choline NA 5.06E-05 no no no up up no capric acid C6+blood Sarcosine+blood 0 0 -0.474871795 serum_scfa serum_choline 0.433 5.06E-05 no no no up up no Cellular senescence Sarcosine+blood 0 0 0.424615385 kegg serum_choline NA 5.06E-05 no no no up up no Choline+blood Sarcosine+blood 0 0.531862745 0 serum_choline serum_choline 0.0395 5.06E-05 no up no up up no Cocaine addiction Sarcosine+blood 0 0 0.484615385 kegg serum_choline NA 5.06E-05 no no no up up no Colorectal cancer Sarcosine+blood 0 -0.511764706 0 kegg serum_choline NA 5.06E-05 no no no up up no Creatinine+blood Sarcosine+blood 0 0.659313725 0 serum_choline serum_choline 0.437 5.06E-05 no no no up up no Cytosolic DNA-sensing pathway Sarcosine+blood 0 0 0.514615385 kegg serum_choline NA 5.06E-05 no no no up up no d18:0-16:0-SM+blood Sarcosine+blood 0 0 0.409230769 serum_phospholipids serum_choline 0.202 5.06E-05 no no no up up no d18:1-16:0-SM+blood Sarcosine+blood 0 0 0.431111111 serum_phospholipids serum_choline 0.14 5.06E-05 no no no up up no DCA+stool Sarcosine+blood -0.565934066 0 0 stool_bileacids serum_choline 0.195 5.06E-05 no no no up up no DL-methionine sulfoxide+blood Sarcosine+blood 0.473684211 0 0 serum_aminoacids serum_choline 0.302 5.06E-05 no no no up up no DMG+blood Sarcosine+blood 0 0.573529412 0 serum_choline serum_choline 0.909 5.06E-05 no no no up up no ErbB signaling pathway Sarcosine+blood 0 -0.538235294 0 kegg serum_choline NA 5.06E-05 no no no up up no Estrogen signaling pathway Sarcosine+blood 0 0 -0.426153846 kegg serum_choline NA 5.06E-05 no no no up up no FoxO signaling pathway Sarcosine+blood 0 0 -0.608461538 kegg serum_choline NA 5.06E-05 no no no up up no Gastric cancer Sarcosine+blood 0 -0.594117647 0 kegg serum_choline NA 5.06E-05 no no no up up no GLCA+blood Sarcosine+blood 0 0 -0.462609563 serum_bileacids serum_choline 0.319 5.06E-05 no no no up up no GPC+blood Sarcosine+blood 0 0.485294118 0 serum_choline serum_choline 0.00427 5.06E-05 no up up up up no Graft-versus-host disease Sarcosine+blood 0 0 0.432307692 kegg serum_choline NA 5.06E-05 no no no up up no HCA+blood Sarcosine+blood 0.470899002 0 0 serum_bileacids serum_choline 0.544 5.06E-05 no no no up up no HDCA+blood Sarcosine+blood 0 0 -0.52316725 serum_bileacids serum_choline 0.483 5.06E-05 no no no up up no Hepatitis C Sarcosine+blood 0 0 0.402307692 kegg serum_choline NA 5.06E-05 no no no up up no Human papillomavirus infection Sarcosine+blood 0 0 0.477692308 kegg serum_choline NA 5.06E-05 no no no up up no iso-heptanoic acid C7+blood Sarcosine+blood 0.476691729 0 0 serum_mcfa serum_choline 0.00256 5.06E-05 up up no up up no iso-LCA+blood Sarcosine+blood 0 0 -0.483504142 serum_bileacids serum_choline 0.507 5.06E-05 no no no up up no iso-LCA+stool Sarcosine+blood 0 0 -0.485714286 stool_bileacids serum_choline 0.72 5.06E-05 no no no up up no isovaleric acid iso-C5+blood Sarcosine+blood 0.52481203 0 0 serum_scfa serum_choline 0.117 5.06E-05 no no no up up no Kaposi sarcoma-associated herpesvirus infection Sarcosine+blood 0 0 0.496153846 kegg serum_choline NA 5.06E-05 no no dn up up no L-Alanine+blood Sarcosine+blood 0.694736842 0.850490196 0.612991453 yes serum_aminoacids serum_choline 0.00138 5.06E-05 up up no up up no L-Arginine+blood Sarcosine+blood 0 0.526960784 0 serum_aminoacids serum_choline 0.316 5.06E-05 no no no up up no L-Asparagine+blood Sarcosine+blood 0.487218045 0 0 serum_aminoacids serum_choline 0.784 5.06E-05 no no no up up no L-Glutamic acid+blood Sarcosine+blood 0 0.549019608 0 yes serum_aminoacids serum_choline 6.20E-05 5.06E-05 up up no up up no L-Homocystine+blood Sarcosine+blood 0 0 -0.495384615 serum_aminoacids serum_choline 0.197 5.06E-05 no no no up up no L-Leucine+blood Sarcosine+blood 0 0.745098039 0 yes serum_aminoacids serum_choline 3.22E-05 5.06E-05 up up no up up no L-Methionine+blood Sarcosine+blood 0 0.745098039 0 serum_aminoacids serum_choline 0.626 5.06E-05 no no no up up no L-Ornithine+blood Sarcosine+blood 0.538345865 0 0 serum_aminoacids serum_choline 0.175 5.06E-05 no no no up up no L-Phenylalanine+blood Sarcosine+blood 0 0.522058824 0 yes serum_aminoacids serum_choline 0.0103 5.06E-05 up up no up up no L-Tryptophan+blood Sarcosine+blood 0 0.634803922 0 serum_aminoacids serum_choline 0.164 5.06E-05 no no no up up no lauric acid C12+blood Sarcosine+blood 0 0 -0.467350427 serum_mcfa serum_choline 0.015 5.06E-05 no dn dn up up no Longevity regulating pathway - multiple species Sarcosine+blood 0 0 -0.540769231 kegg serum_choline NA 5.06E-05 no no no up up no Methanobrevibacter Sarcosine+blood 0 0 -0.404411013 Genus serum_choline 0.629 5.06E-05 no no no up up no Neuroactive ligand-receptor interaction Sarcosine+blood 0 0 -0.434615385 kegg serum_choline NA 5.06E-05 up up up up up no Non-small cell lung cancer Sarcosine+blood 0 -0.544117647 0 kegg serum_choline NA 5.06E-05 no no no up up no nonanoic acid C9+blood Sarcosine+blood 0 0 -0.401025641 serum_mcfa serum_choline 6.51E-11 5.06E-05 dn dn no up up no Oocyte meiosis Sarcosine+blood -0.584210526 0 0 kegg serum_choline NA 5.06E-05 no no no up up no Oxytocin signaling pathway Sarcosine+blood 0.492982456 0 0 kegg serum_choline NA 5.06E-05 no no no up up no Pancreatic cancer Sarcosine+blood 0 -0.623529412 0 kegg serum_choline NA 5.06E-05 no no no up up no Phenylacetic acid+stool Sarcosine+blood 0 0 -0.521804511 stool_cometabolism serum_choline 0.785 5.06E-05 no no no up up no Platinum drug resistance Sarcosine+blood 0 0 -0.490769231 kegg serum_choline NA 5.06E-05 no no no up up no Primary immunodeficiency Sarcosine+blood 0 0 -0.552307692 kegg serum_choline NA 5.06E-05 no no no up up no Progesterone-mediated oocyte maturation Sarcosine+blood -0.540350877 0 0 kegg serum_choline NA 5.06E-05 no no no up up no Proteasome Sarcosine+blood -0.466666667 0 0 kegg serum_choline NA 5.06E-05 no no no up up no Relaxin signaling pathway Sarcosine+blood 0 0 0.485384615 kegg serum_choline NA 5.06E-05 no no no up up no Renal cell carcinoma Sarcosine+blood 0 -0.652941176 0 kegg serum_choline NA 5.06E-05 no no no up up no Ribosome biogenesis in eukaryotes Sarcosine+blood -0.536842105 0 0 kegg serum_choline NA 5.06E-05 no no no up up no RIG-I-like receptor signaling pathway Sarcosine+blood 0 0 0.426153846 kegg serum_choline NA 5.06E-05 no no no up up no Sphingolipid signaling pathway Sarcosine+blood 0 -0.505882353 0 kegg serum_choline NA 5.06E-05 no no no up up no Spinocerebellar ataxia Sarcosine+blood -0.50877193 0 0 kegg serum_choline NA 5.06E-05 no no no up up no Spliceosome Sarcosine+blood -0.494736842 0 0 kegg serum_choline NA 5.06E-05 no no no up up no TNF signaling pathway Sarcosine+blood 0 0 0.442307692 kegg serum_choline NA 5.06E-05 no no no up up no Type I diabetes mellitus Sarcosine+blood 0 0 0.453076923 kegg serum_choline NA 5.06E-05 no no no up up no Vibrio cholerae infection Sarcosine+blood 0 0.5 0 kegg serum_choline NA 5.06E-05 no no no up up no Viral carcinogenesis Sarcosine+blood 0 0 0.491538462 kegg serum_choline NA 5.06E-05 no no no up up no Ascorbate and aldarate metabolism Selenocompound metabolism 0 0 0.687001287 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Selenocompound metabolism 0 0 0.635521236 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Selenocompound metabolism 0 0 0.44015444 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Selenocompound metabolism 0 0.457509881 0 kegg kegg NA NA no no no no no no Histidine metabolism Selenocompound metabolism 0 0 0.403861004 kegg kegg NA NA no no no no no no Lysine degradation Selenocompound metabolism 0.654782609 0.758893281 0.735392535 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Selenocompound metabolism 0 0 0.481595882 kegg kegg NA NA no no no no no no Pentose phosphate pathway Selenocompound metabolism 0 -0.503952569 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Selenocompound metabolism 0 0 0.576576577 kegg kegg NA NA no no no no no no Steroid biosynthesis Selenocompound metabolism 0.426086957 0 0.553153153 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Selenocompound metabolism 0 0 0.595624196 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Selenocompound metabolism 0.426086957 0.639328063 0.646589447 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Selenocompound metabolism 0.648695652 0.596837945 0.565250965 kegg kegg NA NA no no no no no no Tryptophan metabolism Selenocompound metabolism 0 0 0.465122265 kegg kegg NA NA no up no no no no Ubiquinone and other terpenoid-quinone biosynthesis Selenocompound metabolism 0 0.575098814 0.684942085 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Selenocompound metabolism 0 0.425889328 0.587644788 kegg kegg NA NA no no no no no no 11-HETE+blood Serine+blood 0 0 0.406246789 serum_ARA serum_aminoacids 0.464 0.942 no no no no no no 14:0-LPC+blood Serine+blood -0.606015038 -0.62745098 -0.557606838 serum_phospholipids serum_aminoacids 0.00689 0.942 up up no no no no 14:0/16:0-PC+blood Serine+blood 0 -0.56127451 0 serum_phospholipids serum_aminoacids 0.0358 0.942 no up no no no no 14:0/18:0-PC+blood Serine+blood 0 -0.517156863 0 serum_phospholipids serum_aminoacids 0.00289 0.942 up up no no no no 14:0/18:2-PC+blood Serine+blood -0.657142857 -0.512254902 -0.643760684 serum_phospholipids serum_aminoacids 0.102 0.942 no up no no no no 14:0/20:4-PC+blood Serine+blood -0.470676692 0 -0.589059829 serum_phospholipids serum_aminoacids 0.486 0.942 no no no no no no 14:0+blood Serine+blood -0.508270677 0 -0.593162393 yes serum_fattyacid serum_aminoacids 0.00572 0.942 up no dn no no no 14:1/18:2-PG+blood Serine+blood 0 0 -0.620512821 serum_phospholipids serum_aminoacids 0.00259 0.942 no up up no no no 16:0/14:0-PC+blood Serine+blood 0 0 0.522735043 serum_phospholipids serum_aminoacids 0.0206 0.942 no up up no no no 16:0/16:0-PC+blood Serine+blood 0 0 0.43042735 serum_phospholipids serum_aminoacids 0.00079 0.942 no up up no no no 16:0/16:0-PI+blood Serine+blood -0.583458647 0 0 serum_phospholipids serum_aminoacids 0.358 0.942 no no no no no no 16:0/16:1-PC+blood Serine+blood 0 -0.492647059 0 serum_phospholipids serum_aminoacids 0.00283 0.942 up up no no no no 16:0/16:1-PI+blood Serine+blood -0.657142857 -0.490196078 0 serum_phospholipids serum_aminoacids 0.262 0.942 no no no no no no 16:0/18:2-PC+blood Serine+blood 0 0.49754902 0.518632479 serum_phospholipids serum_aminoacids 3.24E-06 0.942 no up up no no no 16:0/18:2-PI+blood Serine+blood -0.658646617 0 0 serum_phospholipids serum_aminoacids 0.269 0.942 no no no no no no 16:0/20:4-PC+blood Serine+blood 0.479699248 0 0 serum_phospholipids serum_aminoacids 0.0262 0.942 no up no no no no 16:0/20:4-PI+blood Serine+blood -0.684210526 0 0 serum_phospholipids serum_aminoacids 0.558 0.942 no no no no no no 16:0/22:0-PE+blood Serine+blood 0 0 0.447521368 serum_phospholipids serum_aminoacids 0.00839 0.942 dn no up no no no 16:0/22:6-PC+blood Serine+blood 0 0 0.541196581 serum_phospholipids serum_aminoacids 4.53E-05 0.942 no up up no no no 16:1/16:0-PC+blood Serine+blood 0.45112782 0.730392157 0.536410256 serum_phospholipids serum_aminoacids 0.0215 0.942 no up up no no no 16:1/16:1-PC+blood Serine+blood 0 0.637254902 0 serum_phospholipids serum_aminoacids 0.0177 0.942 no no up no no no 18:0/16:0-PC+blood Serine+blood 0 0.534313725 0 serum_phospholipids serum_aminoacids 9.64E-07 0.942 up up up no no no 18:0/18:0-PC+blood Serine+blood 0 0 0.403760684 serum_phospholipids serum_aminoacids 0.426 0.942 no no no no no no 18:0/18:0-PE+blood Serine+blood -0.460150376 0 -0.545982906 serum_phospholipids serum_aminoacids 0.00896 0.942 up up no no no no 18:0/18:1-PE+blood Serine+blood -0.527819549 0 -0.48034188 serum_phospholipids serum_aminoacids 0.00716 0.942 up up no no no no 18:0/18:1-PG+blood Serine+blood 0 -0.50245098 -0.548717949 serum_phospholipids serum_aminoacids 0.000842 0.942 no up no no no no 18:0/18:2-PC+blood Serine+blood 0 0 0.502222222 serum_phospholipids serum_aminoacids 1.74E-06 0.942 no up up no no no 18:0/18:2-PI+blood Serine+blood -0.469172932 0 0 serum_phospholipids serum_aminoacids 0.179 0.942 no no no no no no 18:1/16:0-PC+blood Serine+blood 0 0.524509804 0.52957265 serum_phospholipids serum_aminoacids 2.43E-05 0.942 no up up no no no 18:1/16:0-PE+blood Serine+blood -0.44962406 0 -0.457094017 serum_phospholipids serum_aminoacids 0.000182 0.942 up up no no no no 18:1/16:0-PI+blood Serine+blood -0.57443609 0 0 serum_phospholipids serum_aminoacids 0.793 0.942 no no no no no no 18:1/18:0-PC+blood Serine+blood 0 0 0.497435897 serum_phospholipids serum_aminoacids 1.83E-06 0.942 no up up no no no 18:1/18:0-PE+blood Serine+blood 0 0 -0.500854701 serum_phospholipids serum_aminoacids 1.39E-06 0.942 up up no no no no 18:1/18:1-PE+blood Serine+blood 0 0 -0.461880342 serum_phospholipids serum_aminoacids 1.03E-05 0.942 up up no no no no 18:1/18:2-PE+blood Serine+blood 0 0 -0.509059829 serum_phospholipids serum_aminoacids 0.000293 0.942 up up no no no no 18:1/20:4-PC+blood Serine+blood 0.448120301 0.487745098 0 serum_phospholipids serum_aminoacids 0.582 0.942 no no no no no no 18:3/16:0-PE+blood Serine+blood -0.479699248 0 -0.421538462 serum_phospholipids serum_aminoacids 0.00149 0.942 up up no no no no 18:3n6+blood Serine+blood -0.571428571 -0.639705882 0 serum_fattyacid serum_aminoacids 0.0463 0.942 up no dn no no no 20:0/20:4-PE+blood Serine+blood 0 -0.595588235 -0.537777778 serum_phospholipids serum_aminoacids 0.00128 0.942 up up no no no no 20:1-LPC+blood Serine+blood 0 0 0.517948718 serum_phospholipids serum_aminoacids 0.217 0.942 no no no no no no 20:1/20:4-PE+blood Serine+blood 0 0 -0.522735043 serum_phospholipids serum_aminoacids 0.0042 0.942 up up no no no no 20:2/18:1-PE+blood Serine+blood -0.518796992 0 -0.433162393 serum_phospholipids serum_aminoacids 0.00208 0.942 up up no no no no 20:3/16:0-PC+blood Serine+blood 0.518796992 0 0 serum_phospholipids serum_aminoacids 0.00405 0.942 no up up no no no 20:3/18:0-PC+blood Serine+blood 0 0.585784314 0.55965812 serum_phospholipids serum_aminoacids 0.296 0.942 no no no no no no 20:3n6+blood Serine+blood -0.47518797 0 0 serum_fattyacid serum_aminoacids 0.0884 0.942 up no no no no no 20:4-LPA+blood Serine+blood 0 0.539215686 0 serum_phospholipids serum_aminoacids 0.398 0.942 no no no no no no 20:4/16:0-PE+blood Serine+blood 0 0 -0.517948718 serum_phospholipids serum_aminoacids 0.00529 0.942 no up up no no no 20:5/18:0-PC+blood Serine+blood 0 0.512254902 0.447521368 serum_phospholipids serum_aminoacids 3.97E-06 0.942 no up up no no no 24:1+blood Serine+blood 0.541353383 0 0.620512821 serum_fattyacid serum_aminoacids 0.00582 0.942 no dn dn no no no Acetic acid+stool Serine+blood 0 0.645454545 0 yes stool_scfa serum_aminoacids 0.0656 0.942 dn no no no no no Adipocytokine signaling pathway Serine+blood 0.492982456 0 0 kegg serum_aminoacids NA 0.942 no no no no no no Alistipes Serine+blood 0 -0.484365511 0 Genus serum_aminoacids 0.0114 0.942 no up no no no no AMPK signaling pathway Serine+blood 0 -0.514705882 0 kegg serum_aminoacids NA 0.942 no no no no no no Arginine and proline metabolism Serine+blood 0 0.532352941 0 kegg serum_aminoacids NA 0.942 no up no no no no Axon guidance Serine+blood 0 -0.520588235 0 kegg serum_aminoacids NA 0.942 no up up no no no B cell receptor signaling pathway Serine+blood 0.650877193 0 0 kegg serum_aminoacids NA 0.942 no no no no no no Betaine+blood Serine+blood 0 0 0.526153846 serum_choline serum_aminoacids 0.857 0.942 no no no no no no Butyricimonas Serine+blood 0 -0.485077898 0 butyrate-producing Genus serum_aminoacids 0.17 0.942 no no no no no no CA+blood Serine+blood 0 -0.689147892 0 serum_bileacids serum_aminoacids 0.606 0.942 no no no no no no Central carbon metabolism in cancer Serine+blood -0.463157895 -0.714705882 0 kegg serum_aminoacids NA 0.942 no no no no no no Choline+blood Serine+blood 0.551879699 0 0 serum_choline serum_aminoacids 0.0395 0.942 no up no no no no Colorectal cancer Serine+blood 0 -0.702941176 0 kegg serum_aminoacids NA 0.942 no no no no no no Coronavirus disease - COVID-19 Serine+blood 0 -0.517647059 0 kegg serum_aminoacids NA 0.942 no no no no no no Creatinine+blood Serine+blood 0.642105263 0 0 serum_choline serum_aminoacids 0.437 0.942 no no no no no no Cysteine+blood Serine+blood 0 0 0.561025641 yes serum_aminoacids serum_aminoacids 1.81E-07 0.942 dn up up no no no Cystine+blood Serine+blood 0.661654135 0 0.638974359 yes serum_aminoacids serum_aminoacids 0.00028 0.942 up up no no no no Cytokine-cytokine receptor interaction Serine+blood 0 0.629411765 0 kegg serum_aminoacids NA 0.942 no no no no no no d18:1-14:0-SM+blood Serine+blood 0 -0.524509804 -0.438632479 serum_phospholipids serum_aminoacids 0.94 0.942 no no no no no no d18:1-14:1-SM+blood Serine+blood 0 0 -0.456410256 serum_phospholipids serum_aminoacids 0.0952 0.942 no dn no no no no DCA+stool Serine+blood 0 0 -0.77593985 stool_bileacids serum_aminoacids 0.195 0.942 no no no no no no DMG+blood Serine+blood 0.529323308 0 0 serum_choline serum_aminoacids 0.909 0.942 no no no no no no EGFR tyrosine kinase inhibitor resistance Serine+blood 0 -0.511764706 0 kegg serum_aminoacids NA 0.942 no no no no no no Estrogen signaling pathway Serine+blood -0.587719298 0 0 kegg serum_aminoacids NA 0.942 no no no no no no Fc epsilon RI signaling pathway Serine+blood 0.484210526 0 0 kegg serum_aminoacids NA 0.942 no no no no no no GCA+blood Serine+blood 0 -0.482843137 0 yes serum_bileacids serum_aminoacids 0.16 0.942 no no no no no no Glycine+blood Serine+blood 0.615037594 0.482843137 0.698461538 serum_aminoacids serum_aminoacids 0.00408 0.942 dn no up no no no Glycolysis / Gluconeogenesis Serine+blood -0.471929825 0 0 kegg serum_aminoacids NA 0.942 no no no no no no HCA+blood Serine+blood 0 -0.796684778 0 serum_bileacids serum_aminoacids 0.544 0.942 no no no no no no Inflammatory mediator regulation of TRP channels Serine+blood 0 -0.517647059 0 kegg serum_aminoacids NA 0.942 no no no no no no L-2-Aminobutyric acid+blood Serine+blood 0 0 0.503589744 yes serum_aminoacids serum_aminoacids 0.000328 0.942 up up no no no no L-Arginine+blood Serine+blood 0.648120301 0 0.637606838 serum_aminoacids serum_aminoacids 0.316 0.942 no no no no no no L-Asparagine+blood Serine+blood 0.645112782 0.534313725 0.64991453 serum_aminoacids serum_aminoacids 0.784 0.942 no no no no no no L-Aspartic acid+blood Serine+blood 0.485714286 0.507352941 0.422222222 yes serum_aminoacids serum_aminoacids 0.0226 0.942 up up no no no no L-Citrulline+blood Serine+blood 0.512781955 0 0 serum_aminoacids serum_aminoacids 0.534 0.942 no no no no no no L-Glutamine+blood Serine+blood 0.754887218 0 0.748376068 serum_aminoacids serum_aminoacids 0.639 0.942 no no no no no no L-Histidine+blood Serine+blood 0 0 0.641025641 serum_aminoacids serum_aminoacids 0.109 0.942 no no no no no no L-Lysine+blood Serine+blood 0.589473684 0 0.52957265 yes serum_aminoacids serum_aminoacids 0.0107 0.942 no up no no no no L-Ornithine+blood Serine+blood 0.476691729 0 0 serum_aminoacids serum_aminoacids 0.175 0.942 no no no no no no L-Phenylalanine+stool Serine+blood 0 0 0.562406015 stool_cometabolism serum_aminoacids 0.398 0.942 no no no no no no L-Threonine+blood Serine+blood 0.648120301 0.676470588 0 serum_aminoacids serum_aminoacids 0.0538 0.942 dn no up no no no L-Tryptophan+blood Serine+blood 0 0 0.534358974 serum_aminoacids serum_aminoacids 0.164 0.942 no no no no no no L-Tyrosine+stool Serine+blood 0 0 0.57593985 stool_cometabolism serum_aminoacids 0.44 0.942 no no no no no no lauric acid C12+blood Serine+blood 0.484210526 0 0 serum_mcfa serum_aminoacids 0.015 0.942 no dn dn no no no LCA+stool Serine+blood 0 0 -0.648120301 stool_bileacids serum_aminoacids 0.314 0.942 no no no no no no Legionellosis Serine+blood -0.666666667 0 0 kegg serum_aminoacids NA 0.942 no no no no no no Lipid and atherosclerosis Serine+blood 0 0.544117647 0 kegg serum_aminoacids NA 0.942 no no no no no no Longevity regulating pathway - multiple species Serine+blood -0.526315789 0 0 kegg serum_aminoacids NA 0.942 no no no no no no Lysosome Serine+blood 0.6 0 0 kegg serum_aminoacids NA 0.942 no no no no no no mRNA surveillance pathway Serine+blood 0 -0.564705882 0 kegg serum_aminoacids NA 0.942 no no no no no no mTOR signaling pathway Serine+blood 0 -0.5 0 kegg serum_aminoacids NA 0.942 no no no no no no MUFA%+blood Serine+blood 0.578947368 0.644607843 0.604102564 serum_fattyacid serum_aminoacids 0.00142 0.942 up no dn no no no octanoic acid C8+blood Serine+blood 0 0 0.427692308 serum_mcfa serum_aminoacids 2.84E-11 0.942 dn dn dn no no no Olfactory transduction Serine+blood 0 0.605882353 0 kegg serum_aminoacids NA 0.942 no no no no no no Pancreatic cancer Serine+blood 0 0 -0.606923077 kegg serum_aminoacids NA 0.942 no no no no no no Primary immunodeficiency Serine+blood -0.656140351 0 0 kegg serum_aminoacids NA 0.942 no no no no no no Propionic acid+stool Serine+blood 0 0 -0.621052632 yes stool_scfa serum_aminoacids 0.0436 0.942 dn no up no no no Proteoglycans in cancer Serine+blood 0 -0.505882353 0 kegg serum_aminoacids NA 0.942 no no no no no no PUFA/UFA+blood Serine+blood 0.643609023 0 0.632820513 serum_fattyacid serum_aminoacids 0.000732 0.942 dn no up no no no PUFA%+blood Serine+blood 0.711278195 0.504901961 0.591111111 serum_fattyacid serum_aminoacids 0.0013 0.942 dn no up no no no Ribosome Serine+blood 0 -0.517647059 0 kegg serum_aminoacids NA 0.942 no no no no no no RNA transport Serine+blood -0.631578947 -0.523529412 0 kegg serum_aminoacids NA 0.942 no no no no no no Slackia Serine+blood 0 0 -0.437711631 Genus serum_aminoacids 0.94 0.942 no no no no no no Spinocerebellar ataxia Serine+blood 0 -0.626470588 0 kegg serum_aminoacids NA 0.942 no no no no no no Th1 and Th2 cell differentiation Serine+blood 0.48245614 0 0 kegg serum_aminoacids NA 0.942 no no no no no no Thermogenesis Serine+blood 0 -0.538235294 0 kegg serum_aminoacids NA 0.942 no no no no no no Yersinia infection Serine+blood 0 0.538235294 0 kegg serum_aminoacids NA 0.942 no no no no no no 2-Oxocarboxylic acid metabolism Serotonergic synapse 0 -0.416996047 -0.52046332 kegg kegg NA NA no no no no no no ABC transporters Serotonergic synapse 0 0 -0.400772201 kegg kegg NA NA no up up no no no Aminoacyl-tRNA biosynthesis Serotonergic synapse 0 0 -0.525353925 kegg kegg NA NA no no no no no no Apelin signaling pathway Serotonergic synapse 0 0 -0.515830116 kegg kegg NA NA no no no no no no Apoptosis Serotonergic synapse 0 0 0.412097812 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Serotonergic synapse 0 0.646245059 0.583783784 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Serotonergic synapse 0 0 -0.714028314 kegg kegg NA NA no no no no no no Autophagy - other Serotonergic synapse 0 0 -0.544658945 kegg kegg NA NA no no no no no no Bacteroides Serotonergic synapse -0.413043478 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Serotonergic synapse 0 0 -0.731016731 kegg kegg NA NA no no no no no no Base excision repair Serotonergic synapse 0 0 -0.567824968 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Serotonergic synapse 0 0 0.52972973 kegg kegg NA NA no no no no no no Butanoate metabolism Serotonergic synapse 0 0 -0.497554698 kegg kegg NA NA no no no no no no cAMP signaling pathway Serotonergic synapse 0 0 0.468983269 yes kegg kegg NA NA no up up no no no Cell cycle Serotonergic synapse 0 0 -0.577091377 kegg kegg NA NA no no no no no no Chemokine signaling pathway Serotonergic synapse 0 0 0.565250965 kegg kegg NA NA no no no no no no Circadian entrainment Serotonergic synapse 0.842608696 0.47826087 0.672586873 kegg kegg NA NA no up up no no no Circadian rhythm Serotonergic synapse 0 0 -0.571685972 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Serotonergic synapse 0 0 -0.709395109 kegg kegg NA NA no no no no no no Complement and coagulation cascades Serotonergic synapse 0 0 0.533590734 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Serotonergic synapse 0 0 -0.418275418 kegg kegg NA NA no no no no no no DNA replication Serotonergic synapse 0 0 -0.646332046 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Serotonergic synapse -0.416521739 0 -0.467953668 kegg kegg NA NA no no no no no no Endocrine resistance Serotonergic synapse 0.412173913 0.511857708 0.508108108 kegg kegg NA NA no no no no no no Ether lipid metabolism Serotonergic synapse 0 0 -0.546975547 kegg kegg NA NA no no no no no no Fanconi anemia pathway Serotonergic synapse 0 0 -0.677734878 kegg kegg NA NA no no no no no no Ferroptosis Serotonergic synapse 0.549565217 0.508893281 0.445559846 kegg kegg NA NA no no no no no no Folate biosynthesis Serotonergic synapse 0 -0.500988142 0 kegg kegg NA NA no no no no no no Galactose metabolism Serotonergic synapse 0 0 -0.404375804 kegg kegg NA NA no no no no no no Gap junction Serotonergic synapse 0.600869565 0.77173913 0.831145431 kegg kegg NA NA no no no no no no Glutamatergic synapse Serotonergic synapse 0.657391304 0.735177866 0.756241956 kegg kegg NA NA no up up no no no Glutathione metabolism Serotonergic synapse 0 0 0.525096525 kegg kegg NA NA no no no no no no Glycerolipid metabolism Serotonergic synapse -0.480869565 0 -0.628571429 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Serotonergic synapse 0 0 -0.709395109 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Serotonergic synapse 0 0 0.574002574 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Serotonergic synapse 0 0 -0.553925354 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Serotonergic synapse 0 0 -0.472586873 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - globo and isoglobo series Serotonergic synapse 0.493043478 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Serotonergic synapse 0 0 -0.597425997 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Serotonergic synapse 0 0 -0.451994852 kegg kegg NA NA no no no no no no Homologous recombination Serotonergic synapse 0 0 -0.566023166 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Serotonergic synapse 0 0 -0.644530245 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Serotonergic synapse 0 -0.433794466 0 kegg kegg NA NA no no no no no no Lysine degradation Serotonergic synapse -0.531304348 0 -0.682368082 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Serotonergic synapse -0.429565217 0 -0.603861004 kegg kegg NA NA no no no no no no mRNA surveillance pathway Serotonergic synapse 0 0 -0.552123552 kegg kegg NA NA no no no no no no mTOR signaling pathway Serotonergic synapse 0 0 -0.487001287 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Serotonergic synapse 0 0 -0.577091377 kegg kegg NA NA no no no no no no Necroptosis Serotonergic synapse 0.431304348 0 0.436808237 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Serotonergic synapse 0 0 0.514285714 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Serotonergic synapse -0.592173913 0 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Serotonergic synapse 0 0 0.471299871 kegg kegg NA NA no no no no no no Notch signaling pathway Serotonergic synapse 0 0 -0.578378378 kegg kegg NA NA no no no no no no Nucleotide excision repair Serotonergic synapse 0 0 -0.534362934 kegg kegg NA NA no no no no no no Odoribacter Serotonergic synapse 0 -0.475979667 0 butyrate-producing Genus kegg 0.798 NA no no no no no no One carbon pool by folate Serotonergic synapse 0 0 -0.664607465 kegg kegg NA NA no no no no no no Oocyte meiosis Serotonergic synapse 0 -0.421936759 0 kegg kegg NA NA no no no no no no Other glycan degradation Serotonergic synapse 0 0 -0.564993565 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Serotonergic synapse 0 0 -0.676705277 kegg kegg NA NA no no no no no no p53 signaling pathway Serotonergic synapse 0 0 -0.449163449 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Serotonergic synapse 0 0 -0.538996139 kegg kegg NA NA no no no no no no Phagosome Serotonergic synapse 0 0 0.401029601 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Serotonergic synapse 0 0 -0.597683398 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Serotonergic synapse 0 0.491106719 0.508880309 kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Serotonergic synapse 0 0 -0.542599743 yes kegg kegg NA NA no up up no no no Platelet activation Serotonergic synapse 0.522608696 0 0.534362934 kegg kegg NA NA no no no no no no Platinum drug resistance Serotonergic synapse 0 0 -0.461261261 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Serotonergic synapse 0 0 0.531016731 kegg kegg NA NA no no no no no no Propanoate metabolism Serotonergic synapse 0 0 -0.421621622 kegg kegg NA NA no no no no no no Proteasome Serotonergic synapse 0 -0.610671937 -0.462290862 kegg kegg NA NA no no no no no no Protein export Serotonergic synapse 0 -0.423913043 -0.544401544 kegg kegg NA NA no no no no no no Rap1 signaling pathway Serotonergic synapse 0 0 0.519433719 kegg kegg NA NA no no no no no no Retinol metabolism Serotonergic synapse 0 0 -0.636036036 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Serotonergic synapse 0 0 -0.762676963 kegg kegg NA NA no no no no no no RNA degradation Serotonergic synapse 0 0 -0.727670528 kegg kegg NA NA no no no no no no RNA polymerase Serotonergic synapse 0 0 -0.717889318 kegg kegg NA NA no no no no no no RNA transport Serotonergic synapse 0 -0.431818182 0 kegg kegg NA NA no no no no no no Ruminococcus Serotonergic synapse 0 -0.502964427 0 acetate-producing Genus kegg 0.335 NA no no no no no no Selenocompound metabolism Serotonergic synapse 0 0 -0.712226512 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Serotonergic synapse 0 0 -0.408236808 kegg kegg NA NA no no no no no no Spliceosome Serotonergic synapse 0 0 -0.615701416 kegg kegg NA NA no no no no no no Steroid biosynthesis Serotonergic synapse 0 0 -0.439382239 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Serotonergic synapse 0 0 -0.475675676 kegg kegg NA NA no no no no no no Sulfur metabolism Serotonergic synapse 0 0 0.473359073 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Serotonergic synapse 0 0 -0.505534106 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Serotonergic synapse 0 0 -0.452767053 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Serotonergic synapse 0 -0.424901186 -0.687258687 kegg kegg NA NA no no no no no no Th17 cell differentiation Serotonergic synapse -0.415652174 -0.469367589 -0.404118404 kegg kegg NA NA no no no no no no Tryptophan metabolism Serotonergic synapse 0 0 -0.604890605 kegg kegg NA NA no up no no no no Ubiquinone and other terpenoid-quinone biosynthesis Serotonergic synapse 0 0 -0.54002574 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Serotonergic synapse 0 0 -0.61003861 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Serotonergic synapse 0 -0.471343874 -0.624195624 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Serotonergic synapse 0 0 0.511454311 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Serotonergic synapse 0 0.515810277 0.481081081 kegg kegg NA NA no no no no no no Wnt signaling pathway Serotonergic synapse 0 0 -0.563191763 kegg kegg NA NA no no no no no no 14:0/20:4-PC+blood SFA%+blood 0 0 -0.437264957 serum_phospholipids serum_fattyacid 0.486 0.0236 no no no no up no 16:0/14:0-PC+blood SFA%+blood 0.494736842 0 0 serum_phospholipids serum_fattyacid 0.0206 0.0236 no up up no up no 16:0/16:0-PC+blood SFA%+blood 0.476691729 0 0 serum_phospholipids serum_fattyacid 0.00079 0.0236 no up up no up no 16:0/16:0-PI+blood SFA%+blood -0.472180451 0 0 serum_phospholipids serum_fattyacid 0.358 0.0236 no no no no up no 16:0/16:1-PI+blood SFA%+blood -0.521804511 0 0 serum_phospholipids serum_fattyacid 0.262 0.0236 no no no no up no 16:0/18:1-PC+blood SFA%+blood 0.667669173 0 0.407179487 serum_phospholipids serum_fattyacid 6.15E-07 0.0236 up up up no up no 16:0/18:2-PC+blood SFA%+blood 0.687218045 0.610294118 0.519316239 serum_phospholipids serum_fattyacid 3.24E-06 0.0236 no up up no up no 16:0/18:2-PI+blood SFA%+blood -0.464661654 0 0 serum_phospholipids serum_fattyacid 0.269 0.0236 no no no no up no 16:0/20:3-PC+blood SFA%+blood 0.518796992 0 0.442735043 serum_phospholipids serum_fattyacid 5.43E-06 0.0236 no up up no up no 16:0/20:4-PC+blood SFA%+blood 0.502255639 0 0 serum_phospholipids serum_fattyacid 0.0262 0.0236 no up no no up no 16:0/20:4-PI+blood SFA%+blood -0.593984962 0 0 serum_phospholipids serum_fattyacid 0.558 0.0236 no no no no up no 16:0/22:6-PC+blood SFA%+blood 0 0 0.489230769 serum_phospholipids serum_fattyacid 4.53E-05 0.0236 no up up no up no 16:1/16:0-PC+blood SFA%+blood 0.609022556 0 0 serum_phospholipids serum_fattyacid 0.0215 0.0236 no up up no up no 18:0-LPA+blood SFA%+blood 0 0.659313725 0 serum_phospholipids serum_fattyacid 0.0725 0.0236 no dn no no up no 18:0-LPE+blood SFA%+blood 0 0 -0.484444444 serum_phospholipids serum_fattyacid 0.491 0.0236 no no no no up no 18:0/16:0-PC+blood SFA%+blood 0.661654135 0 0 serum_phospholipids serum_fattyacid 9.64E-07 0.0236 up up up no up no 18:0/18:0-PE+blood SFA%+blood -0.544360902 0 -0.481709402 serum_phospholipids serum_fattyacid 0.00896 0.0236 up up no no up no 18:0/18:1-PE+blood SFA%+blood -0.563909774 0 -0.435213675 serum_phospholipids serum_fattyacid 0.00716 0.0236 up up no no up no 18:0/18:1-PG+blood SFA%+blood 0 0 -0.466666667 serum_phospholipids serum_fattyacid 0.000842 0.0236 no up no no up no 18:0/18:2-PC+blood SFA%+blood 0.562406015 0 0.441367521 serum_phospholipids serum_fattyacid 1.74E-06 0.0236 no up up no up no 18:0/20:4-PC+blood SFA%+blood 0.448120301 0 0 serum_phospholipids serum_fattyacid 0.454 0.0236 no no no no up no 18:1/16:0-PC+blood SFA%+blood 0.696240602 0.598039216 0.513846154 serum_phospholipids serum_fattyacid 2.43E-05 0.0236 no up up no up no 18:1/16:0-PE+blood SFA%+blood 0 0 -0.418803419 serum_phospholipids serum_fattyacid 0.000182 0.0236 up up no no up no 18:1/16:0-PI+blood SFA%+blood -0.458646617 0 0 serum_phospholipids serum_fattyacid 0.793 0.0236 no no no no up no 18:1/18:0-PC+blood SFA%+blood 0.601503759 0 0.44 serum_phospholipids serum_fattyacid 1.83E-06 0.0236 no up up no up no 18:1/18:0-PI+blood SFA%+blood -0.520300752 -0.507352941 0 serum_phospholipids serum_fattyacid 0.0931 0.0236 no no up no up no 18:1/18:1-PC+blood SFA%+blood 0.488721805 0 0.464615385 serum_phospholipids serum_fattyacid 1.34E-05 0.0236 no up up no up no 18:1/18:2-PE+blood SFA%+blood 0 0 -0.461880342 serum_phospholipids serum_fattyacid 0.000293 0.0236 up up no no up no 18:1/20:4-PE+blood SFA%+blood 0 0 -0.487179487 serum_phospholipids serum_fattyacid 0.0578 0.0236 up no no no up no 18:2-LPA+blood SFA%+blood 0 0.531862745 0 serum_phospholipids serum_fattyacid 0.00684 0.0236 dn no up no up no 18:2/16:0-PC+blood SFA%+blood 0.610526316 0 0 serum_phospholipids serum_fattyacid 8.67E-05 0.0236 no up up no up no 18:3n6+blood SFA%+blood -0.512781955 0 0 serum_fattyacid serum_fattyacid 0.0463 0.0236 up no dn no up no 20:0/20:4-PE+blood SFA%+blood 0 0 -0.50017094 serum_phospholipids serum_fattyacid 0.00128 0.0236 up up no no up no 20:1-LPA+blood SFA%+blood 0 0.585784314 0 serum_phospholipids serum_fattyacid 0.0187 0.0236 dn dn no no up no 20:1/20:4-PE+blood SFA%+blood 0 0 -0.478974359 serum_phospholipids serum_fattyacid 0.0042 0.0236 up up no no up no 20:2/18:1-PE+blood SFA%+blood -0.517293233 0 0 serum_phospholipids serum_fattyacid 0.00208 0.0236 up up no no up no 20:3/16:0-PC+blood SFA%+blood 0.536842105 0 0 serum_phospholipids serum_fattyacid 0.00405 0.0236 no up up no up no 20:4-LPA+blood SFA%+blood 0 0.566176471 0 serum_phospholipids serum_fattyacid 0.398 0.0236 no no no no up no 20:4/16:0-PE+blood SFA%+blood -0.520300752 0 -0.499487179 serum_phospholipids serum_fattyacid 0.00529 0.0236 no up up no up no 20:5/18:0-PC+blood SFA%+blood 0 0 0.489230769 serum_phospholipids serum_fattyacid 3.97E-06 0.0236 no up up no up no 22:1-LPA+blood SFA%+blood 0 0.602941176 0 serum_phospholipids serum_fattyacid 0.00373 0.0236 no up up no up no 22:2-LPA+blood SFA%+blood 0 0.544117647 0 serum_phospholipids serum_fattyacid 0.0443 0.0236 dn no no no up no 24:1+blood SFA%+blood 0 0 0.48034188 serum_fattyacid serum_fattyacid 0.00582 0.0236 no dn dn no up no 4-hydroxybenzoic acid+stool SFA%+blood 0 0 0.461654135 stool_cometabolism serum_fattyacid 0.0536 0.0236 no dn no no up no Adrenergic signaling in cardiomyocytes SFA%+blood 0 -0.655882353 0 kegg serum_fattyacid NA 0.0236 no no up no up no AGE-RAGE signaling pathway in diabetic complications SFA%+blood 0 0.567647059 0 kegg serum_fattyacid NA 0.0236 no no no no up no Aldosterone synthesis and secretion SFA%+blood 0 -0.661764706 0 kegg serum_fattyacid NA 0.0236 no up up no up no Alistipes SFA%+blood 0.481512862 0 0 Genus serum_fattyacid 0.0114 0.0236 no up no no up no Allograft rejection SFA%+blood 0 0.582352941 0 kegg serum_fattyacid NA 0.0236 no no no no up no Alzheimer disease SFA%+blood 0 -0.555882353 0 kegg serum_fattyacid NA 0.0236 no no no no up no Amoebiasis SFA%+blood 0 0.561764706 0 kegg serum_fattyacid NA 0.0236 no no no no up no Amphetamine addiction SFA%+blood 0 -0.708823529 0 kegg serum_fattyacid NA 0.0236 no no no no up no Amyotrophic lateral sclerosis SFA%+blood 0 -0.570588235 0 kegg serum_fattyacid NA 0.0236 no no no no up no Apelin signaling pathway SFA%+blood 0 -0.632352941 0 kegg serum_fattyacid NA 0.0236 no no no no up no Apoptosis SFA%+blood 0 0.585294118 0 kegg serum_fattyacid NA 0.0236 no no no no up no Autoimmune thyroid disease SFA%+blood 0 0.582352941 0 kegg serum_fattyacid NA 0.0236 no no no no up no B cell receptor signaling pathway SFA%+blood 0 0.514705882 0 kegg serum_fattyacid NA 0.0236 no no no no up no Biosynthesis of amino acids SFA%+blood 0 0.691176471 0 kegg serum_fattyacid NA 0.0236 no no no no up no Bladder cancer SFA%+blood 0 0.564705882 0 kegg serum_fattyacid NA 0.0236 no no no no up no Breast cancer SFA%+blood 0 0 -0.503076923 kegg serum_fattyacid NA 0.0236 no no no no up no C-type lectin receptor signaling pathway SFA%+blood 0 0.526470588 0 kegg serum_fattyacid NA 0.0236 no no no no up no CA+blood SFA%+blood 0 -0.507664105 0 serum_bileacids serum_fattyacid 0.606 0.0236 no no no no up no Cardiac muscle contraction SFA%+blood 0 -0.523529412 0 kegg serum_fattyacid NA 0.0236 no no up no up no CDCA+blood SFA%+blood 0 -0.56127451 0 serum_bileacids serum_fattyacid 0.506 0.0236 no no no no up no Cell adhesion molecules SFA%+blood 0 0.623529412 0 kegg serum_fattyacid NA 0.0236 no no no no up no Cell cycle SFA%+blood 0 -0.679411765 0 kegg serum_fattyacid NA 0.0236 no no no no up no Cellular senescence SFA%+blood 0 0.644117647 0 kegg serum_fattyacid NA 0.0236 no no no no up no cGMP-PKG signaling pathway SFA%+blood 0 0.538235294 0 kegg serum_fattyacid NA 0.0236 no no no no up no Chemical carcinogenesis - receptor activation SFA%+blood 0 -0.532352941 0 kegg serum_fattyacid NA 0.0236 no no no no up no Chemokine signaling pathway SFA%+blood 0 0.544117647 0 kegg serum_fattyacid NA 0.0236 no no no no up no Choline+blood SFA%+blood 0.488721805 0 0 serum_choline serum_fattyacid 0.0395 0.0236 no up no no up no Colorectal cancer SFA%+blood 0 0 -0.443846154 kegg serum_fattyacid NA 0.0236 no no no no up no Coronavirus disease - COVID-19 SFA%+blood 0 -0.591176471 0.483846154 kegg serum_fattyacid NA 0.0236 no no no no up no Creatinine+blood SFA%+blood 0 0.522058824 0.571965812 serum_choline serum_fattyacid 0.437 0.0236 no no no no up no Cushing syndrome SFA%+blood 0 -0.564705882 0 kegg serum_fattyacid NA 0.0236 no no up no up no Cysteine+blood SFA%+blood 0 0.644607843 0.512478632 yes serum_aminoacids serum_fattyacid 1.81E-07 0.0236 dn up up no up no Cystine+blood SFA%+blood 0 0.723039216 0.545299145 yes serum_aminoacids serum_fattyacid 0.00028 0.0236 up up no no up no Cytosolic DNA-sensing pathway SFA%+blood 0.538596491 0 0 kegg serum_fattyacid NA 0.0236 no no no no up no d18:1-16:1-SM+blood SFA%+blood 0 0 -0.442735043 serum_phospholipids serum_fattyacid 0.2 0.0236 no no no no up no d18:1-18:0-SM+blood SFA%+blood 0.536842105 0 0 serum_phospholipids serum_fattyacid 0.97 0.0236 no no no no up no DCA+stool SFA%+blood 0 0 -0.514285714 stool_bileacids serum_fattyacid 0.195 0.0236 no no no no up no Diabetic cardiomyopathy SFA%+blood 0 -0.541176471 0 kegg serum_fattyacid NA 0.0236 no no no no up no DMG+blood SFA%+blood 0 0 0.439316239 serum_choline serum_fattyacid 0.909 0.0236 no no no no up no Dopaminergic synapse SFA%+blood 0 -0.602941176 0 kegg serum_fattyacid NA 0.0236 no up no no up no DPA+blood SFA%+blood 0 0.490196078 0 serum_ARA serum_fattyacid 0.519 0.0236 no no no no up no EGFR tyrosine kinase inhibitor resistance SFA%+blood 0 -0.635294118 0 kegg serum_fattyacid NA 0.0236 no no no no up no Endocrine resistance SFA%+blood 0 0 -0.530769231 kegg serum_fattyacid NA 0.0236 no no no no up no Endocytosis SFA%+blood 0 0.667647059 0 kegg serum_fattyacid NA 0.0236 no no no no up no Epithelial cell signaling in Helicobacter pylori infection SFA%+blood 0 0.65 0 kegg serum_fattyacid NA 0.0236 no no no no up no ErbB signaling pathway SFA%+blood 0 0 -0.41 kegg serum_fattyacid NA 0.0236 no no no no up no Estrogen signaling pathway SFA%+blood 0 -0.541176471 -0.437692308 kegg serum_fattyacid NA 0.0236 no no no no up no Ethanolamine+blood SFA%+blood 0 0.629901961 0 serum_aminoacids serum_fattyacid 0.122 0.0236 up no no no up no Fc epsilon RI signaling pathway SFA%+blood 0 0.535294118 0 kegg serum_fattyacid NA 0.0236 no no no no up no Fc gamma R-mediated phagocytosis SFA%+blood 0 0.594117647 0 kegg serum_fattyacid NA 0.0236 no no no no up no Fusobacterium SFA%+blood 0 0 0.446866005 Genus serum_fattyacid 0.628 0.0236 no no no no up no Gap junction SFA%+blood 0 0 -0.446923077 kegg serum_fattyacid NA 0.0236 no no no no up no Glucagon signaling pathway SFA%+blood 0 -0.638235294 0 kegg serum_fattyacid NA 0.0236 no no no no up no Glycine+blood SFA%+blood 0.545864662 0.696078431 0.550769231 serum_aminoacids serum_fattyacid 0.00408 0.0236 dn no up no up no Graft-versus-host disease SFA%+blood 0 0.582352941 0 kegg serum_fattyacid NA 0.0236 no no no no up no "Growth hormone synthesis, secretion and action" SFA%+blood 0 0 -0.584615385 kegg serum_fattyacid NA 0.0236 no no no no up no HDCA+blood SFA%+blood 0.518101712 0 0 serum_bileacids serum_fattyacid 0.483 0.0236 no no no no up no heptanoic acid C7+blood SFA%+blood 0 0.5 0.494017094 serum_mcfa serum_fattyacid 8.27E-11 0.0236 dn dn no no up no HIF-1 signaling pathway SFA%+blood 0 -0.5 0 kegg serum_fattyacid NA 0.0236 no no no no up no Human papillomavirus infection SFA%+blood 0 0.6 0 kegg serum_fattyacid NA 0.0236 no no no no up no Huntington disease SFA%+blood 0 -0.523529412 0 kegg serum_fattyacid NA 0.0236 no no no no up no IL-17 signaling pathway SFA%+blood 0 0.626470588 0 kegg serum_fattyacid NA 0.0236 no no no no up no Inflammatory mediator regulation of TRP channels SFA%+blood 0 -0.564705882 0 kegg serum_fattyacid NA 0.0236 no no no no up no Influenza A SFA%+blood 0 0.502941176 0 kegg serum_fattyacid NA 0.0236 no no no no up no Insulin signaling pathway SFA%+blood 0 -0.626470588 0 kegg serum_fattyacid NA 0.0236 no no no no up no iso-DCA+blood SFA%+blood 0.47518797 0 0 serum_bileacids serum_fattyacid 0.38 0.0236 no no no no up no L-Arginine+blood SFA%+blood 0 0.529411765 0.490598291 serum_aminoacids serum_fattyacid 0.316 0.0236 no no no no up no L-Asparagine+blood SFA%+blood 0 0.531862745 0.635555556 serum_aminoacids serum_fattyacid 0.784 0.0236 no no no no up no L-Aspartic acid+blood SFA%+blood 0.590977444 0 0 yes serum_aminoacids serum_fattyacid 0.0226 0.0236 up up no no up no L-Glutamic acid+blood SFA%+blood 0 0.485294118 0 yes serum_aminoacids serum_fattyacid 6.20E-05 0.0236 up up no no up no L-Glutamine+blood SFA%+blood 0.491729323 0 0.632136752 serum_aminoacids serum_fattyacid 0.639 0.0236 no no no no up no L-Histidine+blood SFA%+blood 0.523308271 0 0.558974359 serum_aminoacids serum_fattyacid 0.109 0.0236 no no no no up no L-Isoleucine+blood SFA%+blood 0 0.5 0.468034188 yes serum_aminoacids serum_fattyacid 5.47E-06 0.0236 up up no no up no L-Leucine+blood SFA%+blood 0 0 0.47965812 yes serum_aminoacids serum_fattyacid 3.22E-05 0.0236 up up no no up no L-Lysine+blood SFA%+blood 0 0.620098039 0.409230769 yes serum_aminoacids serum_fattyacid 0.0107 0.0236 no up no no up no L-Methionine+blood SFA%+blood 0 0.556372549 0 serum_aminoacids serum_fattyacid 0.626 0.0236 no no no no up no L-Phenylalanine+blood SFA%+blood 0 0.632352941 0.406495726 yes serum_aminoacids serum_fattyacid 0.0103 0.0236 up up no no up no L-Tryptophan+blood SFA%+blood 0 0.536764706 0.482393162 serum_aminoacids serum_fattyacid 0.164 0.0236 no no no no up no LCA+stool SFA%+blood 0 0 -0.460150376 stool_bileacids serum_fattyacid 0.314 0.0236 no no no no up no Lipid and atherosclerosis SFA%+blood 0 0.782352941 0 kegg serum_fattyacid NA 0.0236 no no no no up no Long-term depression SFA%+blood 0 0 -0.421538462 kegg serum_fattyacid NA 0.0236 no no no no up no Long-term potentiation SFA%+blood 0 -0.597058824 0 kegg serum_fattyacid NA 0.0236 no no up no up no Longevity regulating pathway - multiple species SFA%+blood -0.612280702 0 0 kegg serum_fattyacid NA 0.0236 no no no no up no Lysosome SFA%+blood 0 0.535294118 0 kegg serum_fattyacid NA 0.0236 no no no no up no mRNA surveillance pathway SFA%+blood 0 -0.685294118 0 kegg serum_fattyacid NA 0.0236 no no no no up no mTOR signaling pathway SFA%+blood 0 -0.638235294 0 kegg serum_fattyacid NA 0.0236 no no no no up no MUFA%+blood SFA%+blood 0.610526316 0.784313725 0.656752137 serum_fattyacid serum_fattyacid 0.00142 0.0236 up no dn no up no Natural killer cell mediated cytotoxicity SFA%+blood 0 0.620588235 0 kegg serum_fattyacid NA 0.0236 no no no no up no Neuroactive ligand-receptor interaction SFA%+blood 0 0.611764706 0 kegg serum_fattyacid NA 0.0236 up up up no up no Neutrophil extracellular trap formation SFA%+blood 0 0.561764706 0 kegg serum_fattyacid NA 0.0236 no no no no up no NF-kappa B signaling pathway SFA%+blood 0 0.544117647 0 kegg serum_fattyacid NA 0.0236 no no no no up no Nicotinate and nicotinamide metabolism SFA%+blood 0 0.55 0 kegg serum_fattyacid NA 0.0236 no no no no up no NOD-like receptor signaling pathway SFA%+blood 0 0.614705882 0 kegg serum_fattyacid NA 0.0236 no no no no up no octanoic acid C8+blood SFA%+blood 0 0 0.582905983 serum_mcfa serum_fattyacid 2.84E-11 0.0236 dn dn dn no up no Olfactory transduction SFA%+blood 0 0.520588235 0 kegg serum_fattyacid NA 0.0236 no no no no up no Osteoclast differentiation SFA%+blood 0 0.579411765 0 kegg serum_fattyacid NA 0.0236 no no no no up no Oxidative phosphorylation SFA%+blood 0 -0.514705882 0 kegg serum_fattyacid NA 0.0236 no no no no up no Pancreatic cancer SFA%+blood 0 0 -0.416923077 kegg serum_fattyacid NA 0.0236 no no no no up no "Parathyroid hormone synthesis, secretion and action" SFA%+blood 0 -0.544117647 0 kegg serum_fattyacid NA 0.0236 no no no no up no Pathogenic Escherichia coli infection SFA%+blood 0 0.561764706 0 kegg serum_fattyacid NA 0.0236 no no no no up no Pathways in cancer SFA%+blood 0 0 -0.419230769 kegg serum_fattyacid NA 0.0236 no no no no up no Peroxisome SFA%+blood 0 0.641176471 0 kegg serum_fattyacid NA 0.0236 no no no no up no Pertussis SFA%+blood 0 0.708823529 0 kegg serum_fattyacid NA 0.0236 no no dn no up no Phagosome SFA%+blood 0 0.591176471 0 kegg serum_fattyacid NA 0.0236 no no no no up no Phospholipase D signaling pathway SFA%+blood 0 0 -0.485384615 kegg serum_fattyacid NA 0.0236 no up up no up no PPAR signaling pathway SFA%+blood 0 0.5 0 kegg serum_fattyacid NA 0.0236 no no no no up no Prevotella SFA%+blood -0.496454894 0 0 acetate-producing Genus serum_fattyacid 0.287 0.0236 no no no no up no Prion disease SFA%+blood 0 -0.632352941 0 kegg serum_fattyacid NA 0.0236 no no no no up no Prolactin signaling pathway SFA%+blood 0 0.520588235 0 kegg serum_fattyacid NA 0.0236 no no no no up no Proteasome SFA%+blood 0 0 0.74 kegg serum_fattyacid NA 0.0236 no no no no up no Protein processing in endoplasmic reticulum SFA%+blood 0 -0.7 0 kegg serum_fattyacid NA 0.0236 no no no no up no Proteoglycans in cancer SFA%+blood 0 -0.552941176 0 kegg serum_fattyacid NA 0.0236 no no no no up no PUFA/MUFA+blood SFA%+blood 0.718796992 0.617647059 0.472136752 serum_fattyacid serum_fattyacid 0.00108 0.0236 dn no up no up no PUFA/UFA+blood SFA%+blood 0.969924812 0.909313725 0.868034188 serum_fattyacid serum_fattyacid 0.000732 0.0236 dn no up no up no PUFA%+blood SFA%+blood 0.929323308 0.892156863 0.738119658 serum_fattyacid serum_fattyacid 0.0013 0.0236 dn no up no up no Ras signaling pathway SFA%+blood 0 -0.614705882 0 yes kegg serum_fattyacid NA 0.0236 no up up no up no Relaxin signaling pathway SFA%+blood 0.466666667 0 0 kegg serum_fattyacid NA 0.0236 no no no no up no Retrograde endocannabinoid signaling SFA%+blood 0 -0.629411765 0 kegg serum_fattyacid NA 0.0236 no no up no up no Rheumatoid arthritis SFA%+blood 0 0.65 0 kegg serum_fattyacid NA 0.0236 no no no no up no Ribosome SFA%+blood 0 -0.591176471 0.483846154 kegg serum_fattyacid NA 0.0236 no no no no up no Ribosome biogenesis in eukaryotes SFA%+blood 0 -0.576470588 0 kegg serum_fattyacid NA 0.0236 no no no no up no RIG-I-like receptor signaling pathway SFA%+blood 0 0.523529412 0 kegg serum_fattyacid NA 0.0236 no no no no up no RNA degradation SFA%+blood 0 -0.623529412 0 kegg serum_fattyacid NA 0.0236 no no no no up no RNA transport SFA%+blood 0 -0.576470588 0 kegg serum_fattyacid NA 0.0236 no no no no up no Ruminococcus SFA%+blood 0 0 -0.433817569 Genus serum_fattyacid 0.0679 0.0236 no no dn no up no Serine+blood SFA%+blood 0.62556391 0 0.667692308 serum_aminoacids serum_fattyacid 0.942 0.0236 no no no no up no Spinocerebellar ataxia SFA%+blood 0 -0.55 0 kegg serum_fattyacid NA 0.0236 no no no no up no Staphylococcus aureus infection SFA%+blood 0 0.555882353 0 kegg serum_fattyacid NA 0.0236 up no no no up no Systemic lupus erythematosus SFA%+blood 0 0.555882353 0 kegg serum_fattyacid NA 0.0236 no no no no up no TCA+stool SFA%+blood -0.800550964 0 0 stool_bileacids serum_fattyacid 0.458 0.0236 no no no no up no Thermogenesis SFA%+blood 0 -0.588235294 0 kegg serum_fattyacid NA 0.0236 no no no no up no Toll-like receptor signaling pathway SFA%+blood 0 0.591176471 0 yes kegg serum_fattyacid NA 0.0236 no no no no up no Toxoplasmosis SFA%+blood 0 0.541176471 0 kegg serum_fattyacid NA 0.0236 no no no no up no Transcriptional misregulation in cancer SFA%+blood 0 0 -0.467692308 kegg serum_fattyacid NA 0.0236 no no no no up no Tuberculosis SFA%+blood 0 0.585294118 0 kegg serum_fattyacid NA 0.0236 no no dn no up no Type I diabetes mellitus SFA%+blood 0 0.582352941 0 kegg serum_fattyacid NA 0.0236 no no no no up no Viral carcinogenesis SFA%+blood 0 0.623529412 0 kegg serum_fattyacid NA 0.0236 no no no no up no Viral myocarditis SFA%+blood 0 0.517647059 0 kegg serum_fattyacid NA 0.0236 no no no no up no Wnt signaling pathway SFA%+blood 0 -0.679411765 0 kegg serum_fattyacid NA 0.0236 no no no no up no Yersinia infection SFA%+blood 0 0.573529412 0 kegg serum_fattyacid NA 0.0236 no no no no up no 11-HETE+blood SFA+blood 0 0.516219364 0 serum_ARA serum_fattyacid 0.464 0.0386 no no no up no no 12-HEPE+blood SFA+blood -0.486204163 0 0 serum_ARA serum_fattyacid 0.312 0.0386 no no no up no no 14:0-LPC+blood SFA+blood 0 0 0.48991453 serum_phospholipids serum_fattyacid 0.00689 0.0386 up up no up no no 14:0/16:0-PC+blood SFA+blood 0 0 0.571965812 serum_phospholipids serum_fattyacid 0.0358 0.0386 no up no up no no 14:0/18:0-PC+blood SFA+blood 0 0 0.575384615 serum_phospholipids serum_fattyacid 0.00289 0.0386 up up no up no no 14:0/18:2-PC+blood SFA+blood 0 0 0.418119658 serum_phospholipids serum_fattyacid 0.102 0.0386 no up no up no no 14:0+blood SFA+blood 0.763909774 0.549019608 0.63008547 yes serum_fattyacid serum_fattyacid 0.00572 0.0386 up no dn up no no 16:0/16:0-PI+blood SFA+blood 0 0 0.424273504 serum_phospholipids serum_fattyacid 0.358 0.0386 no no no up no no 16:0/16:1-PC+blood SFA+blood 0 0 0.595897436 serum_phospholipids serum_fattyacid 0.00283 0.0386 up up no up no no 16:0/16:1-PI+blood SFA+blood 0 0 0.496068376 serum_phospholipids serum_fattyacid 0.262 0.0386 no no no up no no 16:0/18:0-PS+blood SFA+blood 0 0.536764706 0 serum_phospholipids serum_fattyacid 0.377 0.0386 no no no up no no 16:0/18:1-PC+blood SFA+blood 0 0 0.524102564 serum_phospholipids serum_fattyacid 6.15E-07 0.0386 up up up up no no 16:0/18:2-PI+blood SFA+blood 0 0 0.433846154 serum_phospholipids serum_fattyacid 0.269 0.0386 no no no up no no 16:0/18:3-PC+blood SFA+blood 0 0 0.429059829 serum_phospholipids serum_fattyacid 0.00216 0.0386 no up up up no no 16:0/20:4-PI+blood SFA+blood 0 0 0.459145299 serum_phospholipids serum_fattyacid 0.558 0.0386 no no no up no no 16:0+blood SFA+blood 0.97443609 0.894607843 0.95965812 yes serum_fattyacid serum_fattyacid 0.00876 0.0386 up no no up no no 16:1-LPC+blood SFA+blood 0 0 0.647179487 serum_phospholipids serum_fattyacid 0.0241 0.0386 no up no up no no 16:1/18:2-PG+blood SFA+blood 0 0.556372549 0 serum_phospholipids serum_fattyacid 1.40E-08 0.0386 no up up up no no 16:1+blood SFA+blood 0.631578947 0.519607843 0.564444444 yes serum_fattyacid serum_fattyacid 0.0186 0.0386 no no dn up no no 18:0/16:0-PC+blood SFA+blood 0 0 0.48991453 serum_phospholipids serum_fattyacid 9.64E-07 0.0386 up up up up no no 18:0/20:4-PI+blood SFA+blood 0 0.526960784 0 serum_phospholipids serum_fattyacid 0.167 0.0386 no no no up no no 18:0+blood SFA+blood 0.801503759 0.762254902 0.578119658 serum_fattyacid serum_fattyacid 0.344 0.0386 no no no up no no 18:1-LPE+blood SFA+blood 0 0 -0.423589744 serum_phospholipids serum_fattyacid 0.117 0.0386 no no no up no no 18:1/18:0-PS+blood SFA+blood 0 0.671568627 0 serum_phospholipids serum_fattyacid 0.193 0.0386 no no no up no no 18:1+blood SFA+blood 0.72481203 0.580882353 0.518632479 yes serum_fattyacid serum_fattyacid 0.00202 0.0386 up no dn up no no 18:2-LPC+blood SFA+blood 0 0 -0.487179487 serum_phospholipids serum_fattyacid 0.00743 0.0386 dn no up up no no 18:2/18:2-PS+blood SFA+blood 0 0.482843137 0 serum_phospholipids serum_fattyacid 0.00674 0.0386 up up no up no no 18:2n6c+blood SFA+blood 0.661654135 0.647058824 0.608205128 serum_fattyacid serum_fattyacid 0.15 0.0386 no no no up no no 18:3n3+blood SFA+blood 0.455639098 0 0 serum_fattyacid serum_fattyacid 0.291 0.0386 no no no up no no 20:2/18:3-PE+blood SFA+blood 0 0.539215686 0 serum_phospholipids serum_fattyacid 0.0391 0.0386 up up no up no no 20:3-LPE+blood SFA+blood 0.479699248 0 0 serum_phospholipids serum_fattyacid 0.084 0.0386 no up no up no no 20:3n6+blood SFA+blood 0.448120301 0 0.612991453 serum_fattyacid serum_fattyacid 0.0884 0.0386 up no no up no no 20:4-LPA+blood SFA+blood 0.527819549 0 0 serum_phospholipids serum_fattyacid 0.398 0.0386 no no no up no no 20:4/18:0-PE+blood SFA+blood 0 0.482843137 0 serum_phospholipids serum_fattyacid 0.000755 0.0386 up up no up no no 22:6n3+blood SFA+blood 0.493233083 0 0 serum_fattyacid serum_fattyacid 0.792 0.0386 no no no up no no 24:0+blood SFA+blood 0 0.56127451 0 serum_fattyacid serum_fattyacid 0.034 0.0386 dn no up up no no 3-(3-Hydroxyphenyl)propanoic acid+stool SFA+blood 0.664835165 0 0 stool_cometabolism serum_fattyacid 0.33 0.0386 no no no up no no AA+blood SFA+blood 0.463157895 0 0 serum_ARA serum_fattyacid 0.212 0.0386 no no no up no no Acetic acid+stool SFA+blood 0 -0.645454545 0 yes stool_scfa serum_fattyacid 0.0656 0.0386 dn no no up no no Adherens junction SFA+blood 0 0 -0.495384615 kegg serum_fattyacid NA 0.0386 no no no up no no Arginine and proline metabolism SFA+blood 0 0 0.452307692 kegg serum_fattyacid NA 0.0386 no up no up no no Arrhythmogenic right ventricular cardiomyopathy SFA+blood 0 0 -0.542307692 kegg serum_fattyacid NA 0.0386 no up up up no no Bacterial invasion of epithelial cells SFA+blood 0 0 -0.556153846 kegg serum_fattyacid NA 0.0386 no no no up no no Betaine+blood SFA+blood 0 0 -0.475555556 serum_choline serum_fattyacid 0.857 0.0386 no no no up no no Bifidobacterium SFA+blood 0 -0.521152765 0 acetate-producing Genus serum_fattyacid 0.105 0.0386 no dn no up no no Central carbon metabolism in cancer SFA+blood 0.589473684 0 0 kegg serum_fattyacid NA 0.0386 no no no up no no Cytosolic DNA-sensing pathway SFA+blood -0.484210526 0 0 kegg serum_fattyacid NA 0.0386 no no no up no no DCA+blood SFA+blood -0.469172932 0 0 serum_bileacids serum_fattyacid 0.122 0.0386 no no no up no no DHA+blood SFA+blood 0.457142857 0 0 serum_ARA serum_fattyacid 0.872 0.0386 no no no up no no Dilated cardiomyopathy SFA+blood 0 0 -0.460769231 kegg serum_fattyacid NA 0.0386 no up up up no no DPA+blood SFA+blood 0.482706767 0 0 serum_ARA serum_fattyacid 0.519 0.0386 no no no up no no EGFR tyrosine kinase inhibitor resistance SFA+blood 0 0 0.413846154 kegg serum_fattyacid NA 0.0386 no no no up no no Focal adhesion SFA+blood 0 0 -0.588461538 kegg serum_fattyacid NA 0.0386 no up up up no no FoxO signaling pathway SFA+blood 0 0 -0.452307692 kegg serum_fattyacid NA 0.0386 no no no up no no Gastric acid secretion SFA+blood 0 0 -0.434615385 kegg serum_fattyacid NA 0.0386 no no no up no no GCDCA+blood SFA+blood 0 0 -0.455042735 serum_bileacids serum_fattyacid 0.31 0.0386 no no no up no no GLCA+blood SFA+blood 0 -0.525105032 -0.462609563 serum_bileacids serum_fattyacid 0.319 0.0386 no no no up no no "Glycine, serine and threonine metabolism" SFA+blood 0 -0.679411765 0 kegg serum_fattyacid NA 0.0386 no up no up no no Hepatocellular carcinoma SFA+blood 0 0 -0.439230769 kegg serum_fattyacid NA 0.0386 no no no up no no Hippo signaling pathway SFA+blood 0 0 -0.57 kegg serum_fattyacid NA 0.0386 no no no up no no Hypertrophic cardiomyopathy SFA+blood 0 0 -0.545384615 kegg serum_fattyacid NA 0.0386 no up up up no no iso-heptanoic acid C7+blood SFA+blood 0 0 0.432478632 serum_mcfa serum_fattyacid 0.00256 0.0386 up up no up no no Kaposi sarcoma-associated herpesvirus infection SFA+blood -0.496491228 0 0 kegg serum_fattyacid NA 0.0386 no no dn up no no L-Phenylalanine+stool SFA+blood 0 -0.636363636 0 stool_cometabolism serum_fattyacid 0.398 0.0386 no no no up no no L-Proline+blood SFA+blood 0 0 -0.416752137 yes serum_aminoacids serum_fattyacid 0.00265 0.0386 up up no up no no L-Threonine+blood SFA+blood 0 -0.485294118 0 serum_aminoacids serum_fattyacid 0.0538 0.0386 dn no up up no no Leukocyte transendothelial migration SFA+blood 0 0 -0.523076923 kegg serum_fattyacid NA 0.0386 no no no up no no Longevity regulating pathway - multiple species SFA+blood 0.466666667 0 0 kegg serum_fattyacid NA 0.0386 no no no up no no mTOR signaling pathway SFA+blood 0 0 0.450769231 kegg serum_fattyacid NA 0.0386 no no no up no no MUFA+blood SFA+blood 0.717293233 0.62745098 0.535042735 serum_fattyacid serum_fattyacid 0.00175 0.0386 up no dn up no no n6+blood SFA+blood 0.827067669 0.867647059 0.765470085 serum_fattyacid serum_fattyacid 0.153 0.0386 no no no up no no Phenylacetic acid+stool SFA+blood 0 -0.645454545 0 stool_cometabolism serum_fattyacid 0.785 0.0386 no no no up no no Platelet activation SFA+blood 0 0 -0.440769231 kegg serum_fattyacid NA 0.0386 no no no up no no Porphyrin and chlorophyll metabolism SFA+blood 0 -0.626470588 0.404615385 kegg serum_fattyacid NA 0.0386 no no no up no no Prevotella SFA+blood 0 0.55364912 0 acetate-producing Genus serum_fattyacid 0.287 0.0386 no no no up no no Progesterone-mediated oocyte maturation SFA+blood 0.498245614 0 0 kegg serum_fattyacid NA 0.0386 no no no up no no PUFA/MUFA+blood SFA+blood -0.454135338 0 0 serum_fattyacid serum_fattyacid 0.00108 0.0386 dn no up up no no PUFA+blood SFA+blood 0.888721805 0.862745098 0.730598291 serum_fattyacid serum_fattyacid 0.212 0.0386 no no no up no no Purine metabolism SFA+blood 0 -0.532352941 0 kegg serum_fattyacid NA 0.0386 no no no up no no Rap1 signaling pathway SFA+blood 0 0 -0.494615385 kegg serum_fattyacid NA 0.0386 no no no up no no RIG-I-like receptor signaling pathway SFA+blood 0 0 0.434615385 kegg serum_fattyacid NA 0.0386 no no no up no no Salmonella infection SFA+blood 0 0 -0.423076923 kegg serum_fattyacid NA 0.0386 no no no up no no Shigellosis SFA+blood -0.510526316 0 0 kegg serum_fattyacid NA 0.0386 no no no up no no Sphingolipid signaling pathway SFA+blood 0 0 -0.477692308 kegg serum_fattyacid NA 0.0386 no no no up no no Thyroid hormone signaling pathway SFA+blood 0 0 -0.474615385 kegg serum_fattyacid NA 0.0386 no no no up no no Vibrio cholerae infection SFA+blood 0 0 -0.406153846 kegg serum_fattyacid NA 0.0386 no no no up no no ABC transporters Shigellosis -0.48 -0.453557312 0 kegg kegg NA NA no up up no no no Adipocytokine signaling pathway Shigellosis 0.554782609 0 0.623680824 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Shigellosis 0.59826087 0.68083004 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Shigellosis -0.460869565 -0.551383399 -0.441956242 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Shigellosis -0.529565217 -0.414031621 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Shigellosis 0.509565217 0.596837945 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Shigellosis 0 0 -0.63963964 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Shigellosis 0 -0.619565217 -0.472586873 kegg kegg NA NA no no no no no no Alzheimer disease Shigellosis 0.489565217 0.836956522 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Shigellosis 0 -0.502964427 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Shigellosis -0.444347826 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Shigellosis 0.493913043 0.504940711 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Shigellosis 0.408695652 0.462450593 0.700643501 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Shigellosis 0.583478261 0.763833992 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Shigellosis 0.445217391 0.60770751 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Shigellosis 0 -0.543478261 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Shigellosis 0 0 0.482368082 kegg kegg NA NA no no no no no no Arginine and proline metabolism Shigellosis 0 -0.463438735 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Shigellosis -0.530434783 0 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Shigellosis 0 0 -0.425225225 kegg kegg NA NA no no no no no no Autophagy - animal Shigellosis 0 -0.419960474 -0.439124839 kegg kegg NA NA no no no no no no Bacteroides Shigellosis -0.474782609 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no beta-Alanine metabolism Shigellosis -0.511304348 0 0 kegg kegg NA NA no no no no no no Bile secretion Shigellosis 0.580869565 0.463438735 0.581209781 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Shigellosis -0.454782609 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Shigellosis 0 0 0.530759331 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Shigellosis -0.593043478 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Shigellosis 0.454782609 0.636363636 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Shigellosis 0.583478261 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Shigellosis 0 -0.416007905 -0.667181467 kegg kegg NA NA no no no no no no Cardiac muscle contraction Shigellosis 0.475652174 0.778656126 0 kegg kegg NA NA no no up no no no Cholesterol metabolism Shigellosis 0.44173913 0 0 yes kegg kegg NA NA no no up no no no Cholinergic synapse Shigellosis 0 -0.485177866 -0.587902188 kegg kegg NA NA no no no no no no Circadian entrainment Shigellosis 0.44173913 0 0.473616474 kegg kegg NA NA no up up no no no Cocaine addiction Shigellosis 0.645217391 0.499011858 0.40978121 kegg kegg NA NA no no no no no no Complement and coagulation cascades Shigellosis 0 -0.433794466 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Shigellosis 0.552173913 0 0 kegg kegg NA NA no no up no no no Cushing syndrome Shigellosis 0.468695652 0 0 kegg kegg NA NA no no up no no no Cytosolic DNA-sensing pathway Shigellosis 0.526086957 0 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Shigellosis 0.614782609 0.483201581 0 kegg kegg NA NA no up no no no no EGFR tyrosine kinase inhibitor resistance Shigellosis 0 0.570158103 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Shigellosis 0.503478261 0.66798419 0.423166023 kegg kegg NA NA no no no no no no ErbB signaling pathway Shigellosis 0 0 -0.667438867 kegg kegg NA NA no no no no no no Ether lipid metabolism Shigellosis 0.56173913 0 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Shigellosis -0.436521739 -0.45256917 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Shigellosis -0.564347826 -0.531620553 0 kegg kegg NA NA no no no no no no Fatty acid degradation Shigellosis -0.810434783 -0.698616601 0 kegg kegg NA NA no no no no no no Fatty acid elongation Shigellosis -0.467826087 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Shigellosis -0.803478261 -0.683794466 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Shigellosis 0 -0.470355731 -0.54002574 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Shigellosis -0.65826087 -0.45256917 0 kegg kegg NA NA no no no no no no Ferroptosis Shigellosis 0.64173913 0.456521739 0.81029601 kegg kegg NA NA no no no no no no FoxO signaling pathway Shigellosis -0.516521739 -0.699604743 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Shigellosis 0 -0.514822134 0 kegg kegg NA NA no no no no no no GABAergic synapse Shigellosis -0.432173913 0 0 kegg kegg NA NA no up up no no no Galactose metabolism Shigellosis -0.523478261 -0.779644269 0 kegg kegg NA NA no no no no no no Gap junction Shigellosis 0 0 0.414671815 kegg kegg NA NA no no no no no no Gastric acid secretion Shigellosis 0 0.475296443 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Shigellosis 0 0.542490119 0 kegg kegg NA NA no no no no no no Glutathione metabolism Shigellosis 0.416521739 0.586956522 0.654826255 kegg kegg NA NA no no no no no no Glycerolipid metabolism Shigellosis -0.415652174 -0.68083004 -0.592535393 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Shigellosis 0 -0.41798419 -0.521235521 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Shigellosis 0 0 0.541827542 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Shigellosis 0 -0.545454545 -0.472329472 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Shigellosis 0 0 -0.505019305 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Shigellosis 0 0 -0.594337194 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Shigellosis -0.622608696 0 0 kegg kegg NA NA no no no no no no GnRH secretion Shigellosis 0 0 -0.587129987 kegg kegg NA NA no up up no no no GnRH signaling pathway Shigellosis 0.522608696 0.416996047 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Shigellosis 0 0 -0.463835264 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Shigellosis -0.466956522 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Shigellosis 0 0.543478261 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Shigellosis 0 -0.570158103 -0.652252252 kegg kegg NA NA no no no no no no Histidine metabolism Shigellosis -0.45826087 -0.447628458 0 kegg kegg NA NA no no no no no no Homologous recombination Shigellosis -0.447826087 0 0 kegg kegg NA NA no no no no no no Huntington disease Shigellosis 0.508695652 0.835968379 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Shigellosis 0.46 0.533596838 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Shigellosis -0.584347826 -0.597826087 -0.589189189 kegg kegg NA NA no no no no no no Insulin secretion Shigellosis 0.45826087 0.479249012 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Shigellosis 0 0.561264822 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Shigellosis -0.485217391 -0.565217391 0 kegg kegg NA NA no no no no no no Long-term depression Shigellosis 0.546086957 0.416996047 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Shigellosis 0 0 0.661518662 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Shigellosis -0.557391304 0 0 kegg kegg NA NA no no no no no no Lysine degradation Shigellosis 0 0 -0.486486486 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Shigellosis 0 0 -0.476962677 kegg kegg NA NA no no no no no no MAPK signaling pathway Shigellosis -0.473913043 -0.704545455 -0.554440154 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Shigellosis 0 0 -0.437065637 kegg kegg NA NA no up no no no no Melanogenesis Shigellosis 0.428695652 0.641304348 0 kegg kegg NA NA no no no no no no Mineral absorption Shigellosis 0.766956522 0.734189723 0.851480051 kegg kegg NA NA no no no no no no Mismatch repair Shigellosis -0.445217391 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Shigellosis 0.917391304 0.91798419 0.957528958 kegg kegg NA NA no no no no no no Morphine addiction Shigellosis 0.590434783 0.425889328 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Shigellosis 0.459130435 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Shigellosis 0.443478261 0.586956522 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Shigellosis 0 -0.516798419 0 kegg kegg NA NA no no no no no no Necroptosis Shigellosis 0.64173913 0.606719368 0.836036036 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Shigellosis -0.496521739 0 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Shigellosis -0.49826087 -0.47826087 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Shigellosis -0.552173913 -0.419960474 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Shigellosis 0.535652174 0.866600791 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Shigellosis -0.550434783 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Shigellosis 0 0 -0.638352638 kegg kegg NA NA no no no no no no Olfactory transduction Shigellosis -0.431304348 0 0 kegg kegg NA NA no no no no no no Oscillospira Shigellosis 0 -0.456521739 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Shigellosis 0 -0.461462451 0 kegg kegg NA NA no no no no no no Other glycan degradation Shigellosis 0 -0.558300395 -0.668468468 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Shigellosis 0 0 -0.515572716 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Shigellosis 0 0 0.461776062 kegg kegg NA NA no up up no no no Oxidative phosphorylation Shigellosis 0.487826087 0.821146245 0 kegg kegg NA NA no no no no no no Pancreatic secretion Shigellosis 0.629565217 0.549407115 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Shigellosis -0.585217391 -0.605731225 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Shigellosis 0.749565217 0.783596838 0.581209781 kegg kegg NA NA no no no no no no Parkinson disease Shigellosis 0.856521739 0.910079051 0.851222651 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Shigellosis 0.848695652 0.909090909 0.852252252 kegg kegg NA NA no no no no no no Peroxisome Shigellosis -0.693043478 -0.472332016 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Shigellosis 0 0 -0.53024453 kegg kegg NA NA no no no no no no Platinum drug resistance Shigellosis 0 -0.536561265 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Shigellosis 0 0.448616601 0.619047619 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Shigellosis -0.480869565 0 0 kegg kegg NA NA no no no no no no Prion disease Shigellosis 0.45826087 0.790513834 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Shigellosis 0 -0.464426877 -0.581467181 kegg kegg NA NA no no no no no no Prolactin signaling pathway Shigellosis 0 -0.433794466 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Shigellosis -0.746956522 -0.794466403 -0.484169884 yes kegg kegg NA NA no up up no no no Protein export Shigellosis 0 0.526679842 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Shigellosis 0 0 0.685199485 kegg kegg NA NA no no no no no no Purine metabolism Shigellosis 0 0.418972332 0.774259974 kegg kegg NA NA no no no no no no Pyrimidine metabolism Shigellosis -0.448695652 0 0 kegg kegg NA NA no no no no no no Ras signaling pathway Shigellosis 0 0 -0.404633205 yes kegg kegg NA NA no up up no no no Regulation of lipolysis in adipocytes Shigellosis 0.460869565 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Shigellosis 0.673043478 0 0 kegg kegg NA NA no no no no no no Renin secretion Shigellosis 0.487826087 0.577075099 0.502702703 kegg kegg NA NA no no no no no no Renin-angiotensin system Shigellosis 0 -0.431818182 0 kegg kegg NA NA no no no no no no Retinol metabolism Shigellosis -0.509565217 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Shigellosis 0 0.751976285 0 kegg kegg NA NA no no up no no no Ribosome Shigellosis 0.684347826 0.776679842 0.526383526 kegg kegg NA NA no no no no no no RNA degradation Shigellosis 0.426086957 0 0 kegg kegg NA NA no no no no no no RNA transport Shigellosis 0 0.475296443 0 kegg kegg NA NA no no no no no no Ruminococcus Shigellosis 0 0.425954748 0 Genus kegg 0.0679 NA no no dn no no no Selenocompound metabolism Shigellosis 0 -0.425889328 -0.461776062 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Shigellosis 0 0 -0.507850708 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Shigellosis 0 -0.585968379 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Shigellosis 0 0 -0.486229086 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Shigellosis 0 0 -0.657657658 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Shigellosis 0 0 -0.41981982 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Shigellosis 0 -0.663043478 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Shigellosis 0 0 -0.4002574 kegg kegg NA NA no no no no no no Sulfur metabolism Shigellosis 0 0 0.518404118 kegg kegg NA NA no no no no no no Taste transduction Shigellosis 0 0 -0.526126126 kegg kegg NA NA no no up no no no TGF-beta signaling pathway Shigellosis 0.435652174 0.42687747 0 kegg kegg NA NA no no no no no no Thermogenesis Shigellosis 0.566086957 0.790513834 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Shigellosis 0.595652174 0.575098814 0.610553411 kegg kegg NA NA no no no no no no Tryptophan metabolism Shigellosis -0.484347826 0 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Shigellosis 0 -0.491106719 -0.616731017 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Shigellosis 0.884347826 0.858695652 0.954440154 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Shigellosis -0.408695652 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Shigellosis 0 0 -0.498584299 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Shigellosis 0.786956522 0.698616601 0.447361647 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Shigellosis 0.517391304 0.596837945 0.466666667 kegg kegg NA NA no no no no no no VEGF signaling pathway Shigellosis 0 0 -0.648391248 kegg kegg NA NA no no no no no no Vibrio cholerae infection Shigellosis 0 0.421936759 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Shigellosis 0 -0.558300395 -0.493951094 kegg kegg NA NA no no no no no no Wnt signaling pathway Shigellosis 0 0 -0.48983269 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Signaling pathways regulating pluripotency of stem cells -0.582608696 0 0 kegg kegg NA NA no no no no no no ABC transporters Signaling pathways regulating pluripotency of stem cells 0 0.565217391 0 kegg kegg NA NA no up up no no no Adherens junction Signaling pathways regulating pluripotency of stem cells 0 -0.429841897 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Signaling pathways regulating pluripotency of stem cells 0.519130435 0 0 kegg kegg NA NA no no up no no no Alistipes Signaling pathways regulating pluripotency of stem cells 0 0.444280709 0 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism Signaling pathways regulating pluripotency of stem cells -0.545217391 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Signaling pathways regulating pluripotency of stem cells -0.633913043 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Signaling pathways regulating pluripotency of stem cells 0 0.553359684 0.471557272 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Signaling pathways regulating pluripotency of stem cells -0.591304348 0 -0.68030888 kegg kegg NA NA no no no no no no Arginine biosynthesis Signaling pathways regulating pluripotency of stem cells 0 0 -0.410553411 kegg kegg NA NA no no no no no no Autophagy - animal Signaling pathways regulating pluripotency of stem cells 0.493913043 0.449604743 0.476705277 kegg kegg NA NA no no no no no no Autophagy - other Signaling pathways regulating pluripotency of stem cells 0.568695652 0.684782609 0.740540541 kegg kegg NA NA no no no no no no Axon guidance Signaling pathways regulating pluripotency of stem cells 0.585217391 0 0 kegg kegg NA NA no up up no no no Basal transcription factors Signaling pathways regulating pluripotency of stem cells 0 0 0.604375804 kegg kegg NA NA no no no no no no beta-Alanine metabolism Signaling pathways regulating pluripotency of stem cells -0.714782609 -0.523715415 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Signaling pathways regulating pluripotency of stem cells -0.702608696 -0.419960474 -0.664350064 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Signaling pathways regulating pluripotency of stem cells -0.486086957 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Signaling pathways regulating pluripotency of stem cells -0.473913043 -0.556324111 0 kegg kegg NA NA no no no no no no Butanoate metabolism Signaling pathways regulating pluripotency of stem cells -0.620869565 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Signaling pathways regulating pluripotency of stem cells 0.656521739 0 0.423423423 kegg kegg NA NA no up up no no no cAMP signaling pathway Signaling pathways regulating pluripotency of stem cells 0.674782609 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Signaling pathways regulating pluripotency of stem cells -0.76173913 -0.586956522 -0.584298584 kegg kegg NA NA no no no no no no Cardiac muscle contraction Signaling pathways regulating pluripotency of stem cells 0.620869565 0 0 kegg kegg NA NA no no up no no no Cell cycle Signaling pathways regulating pluripotency of stem cells 0 0.416007905 0.727413127 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Signaling pathways regulating pluripotency of stem cells -0.467826087 0 0 kegg kegg NA NA no no no no no no Clostridium Signaling pathways regulating pluripotency of stem cells 0 -0.41872905 0 Genus kegg 0.925 NA no no no no no no Collinsella Signaling pathways regulating pluripotency of stem cells 0 0 -0.408658327 Genus kegg 0.128 NA no no no no no no Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells 0 -0.510869565 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Signaling pathways regulating pluripotency of stem cells -0.723478261 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Signaling pathways regulating pluripotency of stem cells 0.485217391 0.473320158 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Signaling pathways regulating pluripotency of stem cells 0.80173913 0.779644269 0.841441441 kegg kegg NA NA no no no no no no Ether lipid metabolism Signaling pathways regulating pluripotency of stem cells 0.431304348 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Signaling pathways regulating pluripotency of stem cells 0 0 0.519176319 kegg kegg NA NA no no no no no no Fatty acid elongation Signaling pathways regulating pluripotency of stem cells -0.66173913 -0.580039526 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Signaling pathways regulating pluripotency of stem cells -0.534782609 0 0 kegg kegg NA NA no no no no no no Ferroptosis Signaling pathways regulating pluripotency of stem cells 0 0 -0.578635779 kegg kegg NA NA no no no no no no Focal adhesion Signaling pathways regulating pluripotency of stem cells 0 -0.526679842 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Signaling pathways regulating pluripotency of stem cells 0 0.41798419 0.545431145 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Signaling pathways regulating pluripotency of stem cells -0.631304348 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Signaling pathways regulating pluripotency of stem cells -0.61826087 0 0 kegg kegg NA NA no no no no no no Gemmiger Signaling pathways regulating pluripotency of stem cells 0 0.441147595 0 butyrate-producing Genus kegg 0.595 NA no no no no no no Glutathione metabolism Signaling pathways regulating pluripotency of stem cells -0.42173913 0 -0.617245817 kegg kegg NA NA no no no no no no Glycerolipid metabolism Signaling pathways regulating pluripotency of stem cells 0 0.489130435 0.558815959 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Signaling pathways regulating pluripotency of stem cells 0 0.51284585 0.63011583 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Signaling pathways regulating pluripotency of stem cells -0.682608696 -0.469367589 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Signaling pathways regulating pluripotency of stem cells 0 0.443675889 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Signaling pathways regulating pluripotency of stem cells 0.507826087 0.571146245 0.64967825 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Signaling pathways regulating pluripotency of stem cells 0.482608696 0 0.44993565 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Signaling pathways regulating pluripotency of stem cells 0 0 -0.419047619 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Signaling pathways regulating pluripotency of stem cells 0.751304348 0.538537549 0.837323037 kegg kegg NA NA no no no no no no Histidine metabolism Signaling pathways regulating pluripotency of stem cells -0.450434783 0 0 kegg kegg NA NA no no no no no no Homologous recombination Signaling pathways regulating pluripotency of stem cells 0 0 0.521492921 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Signaling pathways regulating pluripotency of stem cells 0 0.608695652 0.671557272 kegg kegg NA NA no no no no no no Lachnospira Signaling pathways regulating pluripotency of stem cells 0 -0.529280965 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Lysine degradation Signaling pathways regulating pluripotency of stem cells 0.416521739 0.805335968 0.703732304 kegg kegg NA NA no no no no no no Lysosome Signaling pathways regulating pluripotency of stem cells 0 -0.468379447 -0.424967825 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Signaling pathways regulating pluripotency of stem cells 0.64173913 0.804347826 0.670785071 kegg kegg NA NA no no no no no no MAPK signaling pathway Signaling pathways regulating pluripotency of stem cells 0 0 0.651737452 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Signaling pathways regulating pluripotency of stem cells -0.474782609 0 -0.430630631 kegg kegg NA NA no no no no no no mRNA surveillance pathway Signaling pathways regulating pluripotency of stem cells 0.69826087 0.545454545 0.712226512 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Signaling pathways regulating pluripotency of stem cells 0 0.436758893 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Signaling pathways regulating pluripotency of stem cells 0 0 0.646332046 kegg kegg NA NA no no no no no no Necroptosis Signaling pathways regulating pluripotency of stem cells 0 0 -0.508365508 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Signaling pathways regulating pluripotency of stem cells -0.409565217 -0.503952569 -0.465379665 kegg kegg NA NA up up up no no no Non-homologous end-joining Signaling pathways regulating pluripotency of stem cells -0.58173913 -0.448616601 0 kegg kegg NA NA no no no no no no Notch signaling pathway Signaling pathways regulating pluripotency of stem cells 0.47826087 0.671936759 0.578378378 kegg kegg NA NA no no no no no no One carbon pool by folate Signaling pathways regulating pluripotency of stem cells 0 0 0.445045045 kegg kegg NA NA no no no no no no Oocyte meiosis Signaling pathways regulating pluripotency of stem cells 0 0 0.513256113 kegg kegg NA NA no no no no no no Other glycan degradation Signaling pathways regulating pluripotency of stem cells 0 0.472332016 0.402831403 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Signaling pathways regulating pluripotency of stem cells 0.509565217 0.742094862 0.761647362 kegg kegg NA NA no no no no no no Oxidative phosphorylation Signaling pathways regulating pluripotency of stem cells 0.548695652 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Signaling pathways regulating pluripotency of stem cells 0.493043478 0.531620553 0.538223938 kegg kegg NA NA no no no no no no Pentose phosphate pathway Signaling pathways regulating pluripotency of stem cells -0.463478261 -0.460474308 -0.587644788 kegg kegg NA NA no no no no no no Peroxisome Signaling pathways regulating pluripotency of stem cells 0 0 -0.458172458 kegg kegg NA NA no no no no no no Phagosome Signaling pathways regulating pluripotency of stem cells -0.496521739 0 -0.574002574 kegg kegg NA NA no no no no no no Phenylalanine metabolism Signaling pathways regulating pluripotency of stem cells -0.534782609 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Signaling pathways regulating pluripotency of stem cells 0.774782609 0.480237154 0.815701416 kegg kegg NA NA no no no no no no Platinum drug resistance Signaling pathways regulating pluripotency of stem cells 0 0.678853755 0.643243243 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Signaling pathways regulating pluripotency of stem cells 0 0 -0.423938224 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Signaling pathways regulating pluripotency of stem cells -0.46 -0.538537549 0 kegg kegg NA NA no no no no no no Protein export Signaling pathways regulating pluripotency of stem cells 0.422608696 0 0.422393822 kegg kegg NA NA no no no no no no Pyrimidine metabolism Signaling pathways regulating pluripotency of stem cells -0.633913043 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Signaling pathways regulating pluripotency of stem cells 0 -0.424901186 0 kegg kegg NA NA no no no no no no Ras signaling pathway Signaling pathways regulating pluripotency of stem cells 0.473043478 0 0.600772201 yes kegg kegg NA NA no up up no no no Retinol metabolism Signaling pathways regulating pluripotency of stem cells -0.505217391 0 0 kegg kegg NA NA no no no no no no Ribosome Signaling pathways regulating pluripotency of stem cells 0.520869565 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Signaling pathways regulating pluripotency of stem cells 0 0 0.611325611 kegg kegg NA NA no no no no no no RNA degradation Signaling pathways regulating pluripotency of stem cells 0.675652174 0 0.672072072 kegg kegg NA NA no no no no no no Ruminococcus Signaling pathways regulating pluripotency of stem cells 0 -0.525509289 0 Genus kegg 0.0679 NA no no dn no no no Selenocompound metabolism Signaling pathways regulating pluripotency of stem cells 0 0.496047431 0.552123552 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Signaling pathways regulating pluripotency of stem cells 0.677391304 0 0.553410553 kegg kegg NA NA no no no no no no Spliceosome Signaling pathways regulating pluripotency of stem cells 0 0.713438735 0.687258687 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Signaling pathways regulating pluripotency of stem cells -0.469565217 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Signaling pathways regulating pluripotency of stem cells -0.619130435 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Signaling pathways regulating pluripotency of stem cells -0.60173913 0 -0.58996139 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Signaling pathways regulating pluripotency of stem cells 0.446086957 0.706521739 0.565250965 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Signaling pathways regulating pluripotency of stem cells 0 0 0.449163449 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells 0.516521739 0 0.575032175 kegg kegg NA NA no no no no no no Tight junction Signaling pathways regulating pluripotency of stem cells -0.548695652 -0.641304348 -0.7003861 kegg kegg NA NA no no no no no no Tryptophan metabolism Signaling pathways regulating pluripotency of stem cells -0.603478261 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Signaling pathways regulating pluripotency of stem cells -0.562608696 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Signaling pathways regulating pluripotency of stem cells -0.491304348 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Signaling pathways regulating pluripotency of stem cells -0.493043478 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Signaling pathways regulating pluripotency of stem cells 0 0 0.607979408 kegg kegg NA NA no no no no no no VEGF signaling pathway Signaling pathways regulating pluripotency of stem cells 0.744347826 0 0.66023166 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Signaling pathways regulating pluripotency of stem cells 0 -0.590909091 -0.494723295 kegg kegg NA NA no no no no no no Wnt signaling pathway Signaling pathways regulating pluripotency of stem cells 0.623478261 0 0.717117117 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Small cell lung cancer 0 -0.46541502 -0.549292149 kegg kegg NA NA no no no no no up ABC transporters Small cell lung cancer 0.488695652 0.449604743 0 kegg kegg NA NA no up up no no up Acute myeloid leukemia Small cell lung cancer 0 0.710474308 0.422393822 kegg kegg NA NA no no no no no up Adherens junction Small cell lung cancer -0.54173913 -0.647233202 -0.588159588 kegg kegg NA NA no no no no no up Adipocytokine signaling pathway Small cell lung cancer 0 0.684782609 0.583783784 kegg kegg NA NA no no no no no up AGE-RAGE signaling pathway in diabetic complications Small cell lung cancer 0 0.633399209 0 kegg kegg NA NA no no no no no up "Alanine, aspartate and glutamate metabolism" Small cell lung cancer 0 0.588932806 0 kegg kegg NA NA no no no no no up Aldosterone-regulated sodium reabsorption Small cell lung cancer 0 0.538537549 0 kegg kegg NA NA no no no no no up alpha-Linolenic acid metabolism Small cell lung cancer 0 0 -0.473873874 kegg kegg NA NA no no no no no up Alzheimer disease Small cell lung cancer 0 -0.529644269 0 kegg kegg NA NA no no no no no up Amoebiasis Small cell lung cancer 0 0.518774704 0 kegg kegg NA NA no no no no no up Amphetamine addiction Small cell lung cancer 0 -0.546442688 0 kegg kegg NA NA no no no no no up Amyotrophic lateral sclerosis Small cell lung cancer 0 -0.545454545 0 kegg kegg NA NA no no no no no up Apelin signaling pathway Small cell lung cancer 0 -0.587944664 0 kegg kegg NA NA no no no no no up Apoptosis Small cell lung cancer 0 0.622529644 0 kegg kegg NA NA no no no no no up Apoptosis - multiple species Small cell lung cancer 0.562608696 0 0 kegg kegg NA NA no no no no no up Arachidonic acid metabolism Small cell lung cancer -0.427826087 0 0 kegg kegg NA NA no no no no no up Arginine and proline metabolism Small cell lung cancer 0 0.611660079 0 kegg kegg NA NA no up no no no up Arginine biosynthesis Small cell lung cancer 0 0.546442688 0 kegg kegg NA NA no no no no no up Autophagy - animal Small cell lung cancer 0.51826087 0.834980237 0 kegg kegg NA NA no no no no no up Autophagy - other Small cell lung cancer 0.593043478 0.583003953 0.43989704 kegg kegg NA NA no no no no no up B cell receptor signaling pathway Small cell lung cancer 0.439130435 0.828063241 0.520978121 kegg kegg NA NA no no no no no up Bacterial invasion of epithelial cells Small cell lung cancer -0.515652174 -0.605731225 -0.708880309 kegg kegg NA NA no no no no no up Basal cell carcinoma Small cell lung cancer 0.537391304 0 0.564478764 kegg kegg NA NA no no no no no up Basal transcription factors Small cell lung cancer 0.434782609 0 0 kegg kegg NA NA no no no no no up Base excision repair Small cell lung cancer 0.55826087 0 0 kegg kegg NA NA no no no no no up beta-Alanine metabolism Small cell lung cancer 0 -0.593873518 -0.687516088 kegg kegg NA NA no no no no no up Biosynthesis of cofactors Small cell lung cancer 0 -0.470355731 0 kegg kegg NA NA no no no no no up Biosynthesis of unsaturated fatty acids Small cell lung cancer 0 -0.530632411 -0.65997426 kegg kegg NA NA no no no no no up Bladder cancer Small cell lung cancer 0 0.675889328 0 kegg kegg NA NA no no no no no up Butanoate metabolism Small cell lung cancer 0 -0.677865613 -0.482625483 kegg kegg NA NA no no no no no up C-type lectin receptor signaling pathway Small cell lung cancer 0.455652174 0.82312253 0.631917632 kegg kegg NA NA no no no no no up Calcium signaling pathway Small cell lung cancer 0 0 0.441184041 kegg kegg NA NA no up up no no up cAMP signaling pathway Small cell lung cancer 0 0.613636364 0.668983269 yes kegg kegg NA NA no up up no no up Carbohydrate digestion and absorption Small cell lung cancer 0.548695652 0.691699605 0 kegg kegg NA NA no no no no no up Carbon metabolism Small cell lung cancer -0.422608696 0 -0.604375804 kegg kegg NA NA no no no no no up Cardiac muscle contraction Small cell lung cancer 0 -0.486166008 0 kegg kegg NA NA no no up no no up Cellular senescence Small cell lung cancer 0 0.43083004 0 kegg kegg NA NA no no no no no up Chagas disease Small cell lung cancer 0 0.770750988 0.408494208 kegg kegg NA NA no no no no no up Chemical carcinogenesis - DNA adducts Small cell lung cancer -0.455652174 0 -0.490604891 kegg kegg NA NA no no no no no up Chemical carcinogenesis - receptor activation Small cell lung cancer 0 0 0.474131274 kegg kegg NA NA no no no no no up Chemokine signaling pathway Small cell lung cancer 0 0.542490119 0 kegg kegg NA NA no no no no no up Chronic myeloid leukemia Small cell lung cancer 0.759130435 0.910079051 0.848906049 kegg kegg NA NA no no no no no up Circadian entrainment Small cell lung cancer -0.543478261 -0.692687747 0 kegg kegg NA NA no up up no no up Circadian rhythm Small cell lung cancer 0.424347826 0 0.440669241 kegg kegg NA NA no no no no no up Citrate cycle (TCA cycle) Small cell lung cancer 0 -0.695652174 -0.456113256 kegg kegg NA NA no no no no no up Clostridium Small cell lung cancer 0 -0.437067548 0 Genus kegg 0.925 NA no no no no no up Cocaine addiction Small cell lung cancer 0 0 0.512741313 kegg kegg NA NA no no no no no up Collecting duct acid secretion Small cell lung cancer -0.516521739 -0.419960474 0 kegg kegg NA NA no no no no no up Colorectal cancer Small cell lung cancer 0.475652174 0 0 kegg kegg NA NA no no no no no up Complement and coagulation cascades Small cell lung cancer 0 0 -0.425482625 kegg kegg NA NA no no no no no up Coronavirus disease - COVID-19 Small cell lung cancer 0 -0.494071146 0 kegg kegg NA NA no no no no no up Cortisol synthesis and secretion Small cell lung cancer 0 0 0.462548263 kegg kegg NA NA no no up no no up Cushing syndrome Small cell lung cancer 0 0 0.502445302 kegg kegg NA NA no no up no no up Cysteine and methionine metabolism Small cell lung cancer 0 -0.685770751 0 kegg kegg NA NA no no no no no up Cytokine-cytokine receptor interaction Small cell lung cancer 0 0 -0.47027027 kegg kegg NA NA no no no no no up Cytosolic DNA-sensing pathway Small cell lung cancer 0 0.731225296 0 kegg kegg NA NA no no no no no up DNA replication Small cell lung cancer 0 -0.64229249 0 kegg kegg NA NA no no no no no up Dopaminergic synapse Small cell lung cancer 0 -0.580039526 0 kegg kegg NA NA no up no no no up Drug metabolism - cytochrome P450 Small cell lung cancer -0.449565217 -0.742094862 -0.597168597 kegg kegg NA NA no no no no no up Drug metabolism - other enzymes Small cell lung cancer -0.473043478 -0.717391304 0 kegg kegg NA NA no no no no no up EGFR tyrosine kinase inhibitor resistance Small cell lung cancer 0.489565217 -0.427865613 0 kegg kegg NA NA no no no no no up Endocrine resistance Small cell lung cancer 0 0 0.412355212 kegg kegg NA NA no no no no no up Endometrial cancer Small cell lung cancer 0.530434783 0.792490119 0.518404118 kegg kegg NA NA no no no no no up Epithelial cell signaling in Helicobacter pylori infection Small cell lung cancer 0 0.604743083 0 kegg kegg NA NA no no no no no up ErbB signaling pathway Small cell lung cancer 0.606086957 0.668972332 0 kegg kegg NA NA no no no no no up Estrogen signaling pathway Small cell lung cancer 0 -0.70256917 0 kegg kegg NA NA no no no no no up Fatty acid biosynthesis Small cell lung cancer 0 0.544466403 0 kegg kegg NA NA no no no no no up Fatty acid degradation Small cell lung cancer 0 0 -0.415186615 kegg kegg NA NA no no no no no up Fatty acid elongation Small cell lung cancer -0.437391304 -0.598814229 -0.713770914 kegg kegg NA NA no no no no no up Fatty acid metabolism Small cell lung cancer 0 0 -0.464607465 kegg kegg NA NA no no no no no up Fc epsilon RI signaling pathway Small cell lung cancer 0 0.647233202 0 kegg kegg NA NA no no no no no up Ferroptosis Small cell lung cancer -0.413043478 0 0 kegg kegg NA NA no no no no no up Focal adhesion Small cell lung cancer -0.497391304 -0.693675889 -0.641184041 kegg kegg NA NA no up up no no up FoxO signaling pathway Small cell lung cancer 0 0.554347826 0 kegg kegg NA NA no no no no no up GABAergic synapse Small cell lung cancer 0 0.424901186 0 kegg kegg NA NA no up up no no up Gastric acid secretion Small cell lung cancer -0.580869565 -0.696640316 -0.476447876 kegg kegg NA NA no no no no no up Glucagon signaling pathway Small cell lung cancer 0 -0.480237154 0 kegg kegg NA NA no no no no no up Glutamatergic synapse Small cell lung cancer -0.406086957 0 0 kegg kegg NA NA no up up no no up Glutathione metabolism Small cell lung cancer 0 -0.516798419 0 kegg kegg NA NA no no no no no up Glycerolipid metabolism Small cell lung cancer 0.483478261 0.462450593 0 kegg kegg NA NA no no up no no up Glycerophospholipid metabolism Small cell lung cancer 0.636521739 0 0 kegg kegg NA NA no no up no no up Glycolysis / Gluconeogenesis Small cell lung cancer 0 -0.670948617 -0.640926641 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Small cell lung cancer 0 0.760869565 0 kegg kegg NA NA no no no no no up Glycosphingolipid biosynthesis - globo and isoglobo series Small cell lung cancer -0.697391304 0 0 kegg kegg NA NA no no no no no up Glycosphingolipid biosynthesis - lacto and neolacto series Small cell lung cancer 0 0.596837945 0.432432432 kegg kegg NA NA no no no no no up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Small cell lung cancer 0.504347826 0 0 kegg kegg NA NA no no no no no up Glyoxylate and dicarboxylate metabolism Small cell lung cancer 0 0.539525692 0 kegg kegg NA NA no no no no no up GnRH secretion Small cell lung cancer 0.566086957 0.70256917 0 kegg kegg NA NA no up up no no up "Growth hormone synthesis, secretion and action" Small cell lung cancer 0 0.45256917 0.623166023 kegg kegg NA NA no no no no no up Hematopoietic cell lineage Small cell lung cancer 0 -0.425889328 -0.594851995 kegg kegg NA NA no no no no no up Hepatitis B Small cell lung cancer 0.63826087 0.859683794 0.6998713 kegg kegg NA NA no no no no no up Hepatitis C Small cell lung cancer 0 0.772727273 0.746718147 kegg kegg NA NA no no no no no up HIF-1 signaling pathway Small cell lung cancer 0 -0.514822134 0 kegg kegg NA NA no no no no no up Hippo signaling pathway Small cell lung cancer -0.449565217 -0.663043478 -0.594594595 kegg kegg NA NA no no no no no up Hippo signaling pathway - multiple species Small cell lung cancer 0 0.562252964 0 kegg kegg NA NA no no no no no up Histidine metabolism Small cell lung cancer 0 0 -0.529472329 kegg kegg NA NA no no no no no up Human papillomavirus infection Small cell lung cancer 0 0.48715415 0 kegg kegg NA NA no no no no no up Huntington disease Small cell lung cancer 0 -0.515810277 0 kegg kegg NA NA no no no no no up Inflammatory mediator regulation of TRP channels Small cell lung cancer 0 -0.555335968 0 kegg kegg NA NA no no no no no up Inositol phosphate metabolism Small cell lung cancer 0.52173913 0 0 kegg kegg NA NA no no no no no up Insulin resistance Small cell lung cancer 0.774782609 0.943675889 0.770913771 kegg kegg NA NA no no no no no up Insulin secretion Small cell lung cancer 0 0 0.492149292 yes kegg kegg NA NA no up up no no up Insulin signaling pathway Small cell lung cancer 0 -0.528656126 0 kegg kegg NA NA no no no no no up JAK-STAT signaling pathway Small cell lung cancer 0 0.743083004 0 kegg kegg NA NA no no no no no up Lachnospira Small cell lung cancer 0 -0.5193971 0 butyrate-producing Genus kegg 0.279 NA no no no no no up Leukocyte transendothelial migration Small cell lung cancer -0.527826087 0 -0.573745174 kegg kegg NA NA no no no no no up Long-term potentiation Small cell lung cancer 0 -0.557312253 0 kegg kegg NA NA no no up no no up Longevity regulating pathway Small cell lung cancer 0 0 0.444015444 kegg kegg NA NA no no no no no up Longevity regulating pathway - multiple species Small cell lung cancer 0 0 -0.474646075 kegg kegg NA NA no no no no no up Lysine degradation Small cell lung cancer 0.786086957 0 0 kegg kegg NA NA no no no no no up Mannose type O-glycan biosynthesis Small cell lung cancer 0.610434783 0 0 kegg kegg NA NA no no no no no up Measles Small cell lung cancer 0.5 0 0 kegg kegg NA NA no no no no no up Melanogenesis Small cell lung cancer 0 -0.501976285 0 kegg kegg NA NA no no no no no up Melanoma Small cell lung cancer 0.412173913 0.78458498 0.456885457 kegg kegg NA NA no no no no no up Metabolism of xenobiotics by cytochrome P450 Small cell lung cancer -0.531304348 -0.772727273 -0.67027027 kegg kegg NA NA no no no no no up MicroRNAs in cancer Small cell lung cancer 0.491304348 0.911067194 0 kegg kegg NA NA no no no no no up Mismatch repair Small cell lung cancer 0 -0.661067194 -0.428056628 kegg kegg NA NA no no no no no up mRNA surveillance pathway Small cell lung cancer 0.534782609 0 0 kegg kegg NA NA no no no no no up mTOR signaling pathway Small cell lung cancer 0 -0.421936759 0 kegg kegg NA NA no no no no no up N-Glycan biosynthesis Small cell lung cancer 0 -0.485177866 0 kegg kegg NA NA no no no no no up Natural killer cell mediated cytotoxicity Small cell lung cancer -0.443478261 0 0 kegg kegg NA NA no no no no no up Neuroactive ligand-receptor interaction Small cell lung cancer -0.466956522 0 0 kegg kegg NA NA up up up no no up Neurotrophin signaling pathway Small cell lung cancer 0.446086957 0.829051383 0.515572716 kegg kegg NA NA no no no no no up Neutrophil extracellular trap formation Small cell lung cancer -0.45826087 0 -0.421364221 kegg kegg NA NA no no no no no up NF-kappa B signaling pathway Small cell lung cancer 0.714782609 0.893280632 0.714543115 kegg kegg NA NA no no no no no up Nicotinate and nicotinamide metabolism Small cell lung cancer 0 0.492094862 0 kegg kegg NA NA no no no no no up Nicotine addiction Small cell lung cancer 0 0 0.504761905 kegg kegg NA NA no up up no no up Nitrogen metabolism Small cell lung cancer 0 0.542490119 0 kegg kegg NA NA no no no no no up NOD-like receptor signaling pathway Small cell lung cancer 0 0.684782609 0 kegg kegg NA NA no no no no no up Non-alcoholic fatty liver disease Small cell lung cancer 0 -0.435770751 0 kegg kegg NA NA no no no no no up Non-homologous end-joining Small cell lung cancer 0 -0.674901186 -0.546460746 kegg kegg NA NA no no no no no up Notch signaling pathway Small cell lung cancer 0 0.565217391 0 kegg kegg NA NA no no no no no up Nucleotide excision repair Small cell lung cancer 0 -0.597826087 0 kegg kegg NA NA no no no no no up One carbon pool by folate Small cell lung cancer 0 -0.614624506 0 kegg kegg NA NA no no no no no up Oocyte meiosis Small cell lung cancer 0 -0.662055336 0 kegg kegg NA NA no no no no no up Osteoclast differentiation Small cell lung cancer 0 0.565217391 0 kegg kegg NA NA no no no no no up Other glycan degradation Small cell lung cancer 0 0.485177866 0 kegg kegg NA NA no no no no no up Other types of O-glycan biosynthesis Small cell lung cancer 0.74 0 0 kegg kegg NA NA no no no no no up Oxidative phosphorylation Small cell lung cancer 0 -0.528656126 0 kegg kegg NA NA no no no no no up Oxytocin signaling pathway Small cell lung cancer -0.604347826 -0.557312253 -0.519176319 kegg kegg NA NA no no no no no up p53 signaling pathway Small cell lung cancer 0.752173913 0 0 kegg kegg NA NA no no no no no up Parkinson disease Small cell lung cancer 0 -0.476284585 0 kegg kegg NA NA no no no no no up Pathogenic Escherichia coli infection Small cell lung cancer 0 0 -0.431145431 kegg kegg NA NA no no no no no up Pathways in cancer Small cell lung cancer 0.573913043 0.785573123 0.67027027 kegg kegg NA NA no no no no no up Pathways of neurodegeneration - multiple diseases Small cell lung cancer 0 -0.454545455 0 kegg kegg NA NA no no no no no up Pentose and glucuronate interconversions Small cell lung cancer 0 -0.612648221 0 kegg kegg NA NA no no no no no up Pertussis Small cell lung cancer -0.434782609 0 0 kegg kegg NA NA no no dn no no up Phagosome Small cell lung cancer -0.426086957 0 0 kegg kegg NA NA no no no no no up Phenylalanine metabolism Small cell lung cancer 0 -0.678853755 -0.53024453 kegg kegg NA NA no no no no no up Phospholipase D signaling pathway Small cell lung cancer 0 0.626482213 0 kegg kegg NA NA no up up no no up Phototransduction Small cell lung cancer -0.491304348 -0.76284585 -0.411840412 kegg kegg NA NA no no no no no up PI3K-Akt signaling pathway Small cell lung cancer 0.503478261 0 0 yes kegg kegg NA NA no up up no no up Platelet activation Small cell lung cancer -0.643478261 -0.632411067 -0.455598456 kegg kegg NA NA no no no no no up Platinum drug resistance Small cell lung cancer 0.587826087 0 0 kegg kegg NA NA no no no no no up PPAR signaling pathway Small cell lung cancer 0 0.559288538 0 kegg kegg NA NA no no no no no up Primary bile acid biosynthesis Small cell lung cancer 0 -0.616600791 -0.66975547 kegg kegg NA NA no no no no no up Prion disease Small cell lung cancer 0 -0.589920949 0 kegg kegg NA NA no no no no no up Progesterone-mediated oocyte maturation Small cell lung cancer 0.432173913 0 0 kegg kegg NA NA no no no no no up Prolactin signaling pathway Small cell lung cancer 0 0.684782609 0.493436293 kegg kegg NA NA no no no no no up Propanoate metabolism Small cell lung cancer 0 -0.673913043 0 kegg kegg NA NA no no no no no up Prostate cancer Small cell lung cancer 0.67826087 0.91798419 0.75958816 kegg kegg NA NA no no no no no up Proteasome Small cell lung cancer 0 -0.674901186 0 kegg kegg NA NA no no no no no up Protein export Small cell lung cancer 0 -0.583992095 0 kegg kegg NA NA no no no no no up Protein processing in endoplasmic reticulum Small cell lung cancer 0 -0.446640316 0 kegg kegg NA NA no no no no no up Proteoglycans in cancer Small cell lung cancer 0.437391304 -0.448616601 0 kegg kegg NA NA no no no no no up Proximal tubule bicarbonate reclamation Small cell lung cancer 0 -0.580039526 0 kegg kegg NA NA no no no no no up Pyramidobacter Small cell lung cancer 0 0 0.439150809 Genus kegg 0.45 NA no no no no no up Pyrimidine metabolism Small cell lung cancer 0 -0.626482213 0 kegg kegg NA NA no no no no no up Pyruvate metabolism Small cell lung cancer 0 -0.701581028 0 kegg kegg NA NA no no no no no up Rap1 signaling pathway Small cell lung cancer -0.552173913 -0.445652174 -0.419305019 kegg kegg NA NA no no no no no up Ras signaling pathway Small cell lung cancer 0 -0.537549407 0 yes kegg kegg NA NA no up up no no up Regulation of actin cytoskeleton Small cell lung cancer -0.713913043 -0.623517787 -0.700643501 kegg kegg NA NA no no no no no up Relaxin signaling pathway Small cell lung cancer 0 0.745059289 0.67001287 kegg kegg NA NA no no no no no up Renin secretion Small cell lung cancer -0.540869565 -0.694664032 0 kegg kegg NA NA no no no no no up Retinol metabolism Small cell lung cancer 0 -0.529644269 -0.452252252 kegg kegg NA NA no no no no no up Retrograde endocannabinoid signaling Small cell lung cancer 0 -0.591897233 0 kegg kegg NA NA no no up no no up Ribosome Small cell lung cancer 0 -0.506916996 0 kegg kegg NA NA no no no no no up Ribosome biogenesis in eukaryotes Small cell lung cancer 0.55826087 0 0 kegg kegg NA NA no no no no no up RIG-I-like receptor signaling pathway Small cell lung cancer 0.54173913 0.875494071 0.707335907 kegg kegg NA NA no no no no no up RNA degradation Small cell lung cancer 0.46173913 0 0 kegg kegg NA NA no no no no no up RNA polymerase Small cell lung cancer 0.472173913 0 0 kegg kegg NA NA no no no no no up Roseburia Small cell lung cancer -0.533043478 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no up Salivary secretion Small cell lung cancer -0.622608696 -0.51284585 0 kegg kegg NA NA no no no no no up Salmonella infection Small cell lung cancer 0 0 -0.611325611 kegg kegg NA NA no no no no no up Selenocompound metabolism Small cell lung cancer 0.670434783 0 0 kegg kegg NA NA no no no no no up Serotonergic synapse Small cell lung cancer -0.407826087 0 0 kegg kegg NA NA no no no no no up Signaling pathways regulating pluripotency of stem cells Small cell lung cancer 0.555652174 0.524703557 0 kegg kegg NA NA no no no no no up SNARE interactions in vesicular transport Small cell lung cancer 0.55826087 0.615612648 0 kegg kegg NA NA no no no no no up Sphingolipid signaling pathway Small cell lung cancer 0 0.444664032 0 kegg kegg NA NA no no no no no up Spinocerebellar ataxia Small cell lung cancer 0.482608696 0 0 kegg kegg NA NA no no no no no up Spliceosome Small cell lung cancer 0.606086957 0 0 kegg kegg NA NA no no no no no up Staphylococcus aureus infection Small cell lung cancer 0 0 -0.42985843 kegg kegg NA NA up no no no no up Steroid biosynthesis Small cell lung cancer 0 -0.692687747 -0.415701416 kegg kegg NA NA no no no no no up Steroid hormone biosynthesis Small cell lung cancer -0.513043478 -0.672924901 0 kegg kegg NA NA no no no no no up Sulfur metabolism Small cell lung cancer 0 -0.470355731 0 kegg kegg NA NA no no no no no up Synthesis and degradation of ketone bodies Small cell lung cancer 0 -0.580039526 0 kegg kegg NA NA no no no no no up T cell receptor signaling pathway Small cell lung cancer 0.52173913 0.72826087 0 kegg kegg NA NA no no no no no up Taste transduction Small cell lung cancer 0 -0.485177866 0 kegg kegg NA NA no no up no no up Taurine and hypotaurine metabolism Small cell lung cancer 0.707826087 0.635375494 0 kegg kegg NA NA no no no no no up TGF-beta signaling pathway Small cell lung cancer 0 -0.509881423 0 kegg kegg NA NA no no no no no up Th1 and Th2 cell differentiation Small cell lung cancer 0 0.502964427 0 kegg kegg NA NA no no no no no up Th17 cell differentiation Small cell lung cancer 0.454782609 0.571146245 0 kegg kegg NA NA no no no no no up Thermogenesis Small cell lung cancer 0 -0.579051383 0 kegg kegg NA NA no no no no no up Thiamine metabolism Small cell lung cancer 0 -0.528656126 0 kegg kegg NA NA no no no no no up Thyroid hormone signaling pathway Small cell lung cancer 0 -0.455533597 -0.446846847 kegg kegg NA NA no no no no no up Tight junction Small cell lung cancer -0.500869565 -0.686758893 -0.663063063 kegg kegg NA NA no no no no no up TNF signaling pathway Small cell lung cancer 0.59826087 0.928853755 0.613899614 kegg kegg NA NA no no no no no up Toll-like receptor signaling pathway Small cell lung cancer 0 0.746047431 0 yes kegg kegg NA NA no no no no no up Transcriptional misregulation in cancer Small cell lung cancer 0.54 0.81916996 0.692664093 kegg kegg NA NA no no no no no up Tryptophan metabolism Small cell lung cancer 0 -0.710474308 -0.456113256 kegg kegg NA NA no up no no no up Tuberculosis Small cell lung cancer 0 0 -0.515057915 kegg kegg NA NA no no dn no no up Type II diabetes mellitus Small cell lung cancer 0.47826087 0.787549407 0 kegg kegg NA NA no no no no no up Tyrosine metabolism Small cell lung cancer -0.457391304 -0.780632411 -0.668725869 kegg kegg NA NA no no no no no up Ubiquinone and other terpenoid-quinone biosynthesis Small cell lung cancer 0 -0.611660079 0 kegg kegg NA NA no no no no no up "Valine, leucine and isoleucine degradation" Small cell lung cancer 0 -0.67687747 -0.552380952 kegg kegg NA NA no no no no no up Vascular smooth muscle contraction Small cell lung cancer 0 -0.656126482 0 kegg kegg NA NA no no no no no up Vasopressin-regulated water reabsorption Small cell lung cancer 0 -0.472332016 0 kegg kegg NA NA no no no no no up VEGF signaling pathway Small cell lung cancer 0 0.581027668 0 kegg kegg NA NA no no no no no up Vibrio cholerae infection Small cell lung cancer -0.586956522 -0.626482213 -0.45045045 kegg kegg NA NA no no no no no up Viral carcinogenesis Small cell lung cancer 0 0.531620553 0 kegg kegg NA NA no no no no no up Olsenella SMB53 0 0.434324473 0 Genus Genus 0.269 0.525 no no no no no no ABC transporters SNARE interactions in vesicular transport 0.666086957 0.651185771 0.584298584 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" SNARE interactions in vesicular transport 0 0.462450593 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism SNARE interactions in vesicular transport 0 0.587944664 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis SNARE interactions in vesicular transport 0.429565217 0 0 kegg kegg NA NA no no no no no no Antifolate resistance SNARE interactions in vesicular transport 0.432173913 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism SNARE interactions in vesicular transport 0 0.546442688 0 kegg kegg NA NA no up no no no no Ascorbate and aldarate metabolism SNARE interactions in vesicular transport 0.42173913 0 0 kegg kegg NA NA no no no no no no Base excision repair SNARE interactions in vesicular transport 0.424347826 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway SNARE interactions in vesicular transport -0.490434783 -0.493083004 0 kegg kegg NA NA no up up no no no Cysteine and methionine metabolism SNARE interactions in vesicular transport 0 -0.513833992 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction SNARE interactions in vesicular transport -0.408695652 0 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 SNARE interactions in vesicular transport 0 0 0.438352638 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes SNARE interactions in vesicular transport 0 -0.480237154 0.565508366 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance SNARE interactions in vesicular transport 0 -0.630434783 0 kegg kegg NA NA no no no no no no ErbB signaling pathway SNARE interactions in vesicular transport 0 0.472332016 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway SNARE interactions in vesicular transport 0.49826087 0 0 kegg kegg NA NA no no no no no no Fatty acid degradation SNARE interactions in vesicular transport 0 0.472332016 0 kegg kegg NA NA no no no no no no Folate biosynthesis SNARE interactions in vesicular transport 0.525217391 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway SNARE interactions in vesicular transport 0 0.637351779 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism SNARE interactions in vesicular transport 0 0.60770751 0 kegg kegg NA NA no no no no no no Galactose metabolism SNARE interactions in vesicular transport 0 0.500988142 0 kegg kegg NA NA no no no no no no Glutathione metabolism SNARE interactions in vesicular transport 0 -0.621541502 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism SNARE interactions in vesicular transport 0.606086957 0.748023715 0.468983269 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism SNARE interactions in vesicular transport 0.435652174 0.671936759 0.448133848 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" SNARE interactions in vesicular transport 0 0 -0.406692407 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis SNARE interactions in vesicular transport 0 -0.614624506 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate SNARE interactions in vesicular transport 0 0.658102767 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin SNARE interactions in vesicular transport 0 0 0.417760618 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate SNARE interactions in vesicular transport -0.423478261 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation SNARE interactions in vesicular transport 0 0 0.41981982 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series SNARE interactions in vesicular transport 0 0.488142292 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway SNARE interactions in vesicular transport 0 -0.679841897 0 kegg kegg NA NA no no no no no no Histidine metabolism SNARE interactions in vesicular transport 0.477391304 0 0 kegg kegg NA NA no no no no no no Homologous recombination SNARE interactions in vesicular transport 0.52 0.416007905 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism SNARE interactions in vesicular transport 0.467826087 0.64229249 0 kegg kegg NA NA no no no no no no Lysine degradation SNARE interactions in vesicular transport 0.451304348 0.451581028 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis SNARE interactions in vesicular transport 0 0.416007905 0 kegg kegg NA NA no no no no no no MAPK signaling pathway SNARE interactions in vesicular transport 0 0.579051383 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis SNARE interactions in vesicular transport 0 0.540513834 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway SNARE interactions in vesicular transport 0.604347826 0.752964427 0 kegg kegg NA NA no no no no no no Oocyte meiosis SNARE interactions in vesicular transport 0 -0.446640316 0 kegg kegg NA NA no no no no no no Other glycan degradation SNARE interactions in vesicular transport 0.744347826 0.874505929 0.533333333 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis SNARE interactions in vesicular transport 0.449565217 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation SNARE interactions in vesicular transport 0 -0.688735178 0 kegg kegg NA NA no no no no no no p53 signaling pathway SNARE interactions in vesicular transport 0 0.568181818 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis SNARE interactions in vesicular transport 0 0.463438735 0 kegg kegg NA NA no no dn no no no Phospholipase D signaling pathway SNARE interactions in vesicular transport 0 0.539525692 0 kegg kegg NA NA no up up no no no Platinum drug resistance SNARE interactions in vesicular transport 0 0.538537549 0 kegg kegg NA NA no no no no no no Propanoate metabolism SNARE interactions in vesicular transport 0 -0.540513834 0 kegg kegg NA NA no no no no no no Proteasome SNARE interactions in vesicular transport 0 -0.421936759 0 kegg kegg NA NA no no no no no no Protein export SNARE interactions in vesicular transport 0 -0.460474308 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism SNARE interactions in vesicular transport 0 0 0.603603604 kegg kegg NA NA no no no no no no Pyruvate metabolism SNARE interactions in vesicular transport 0 -0.540513834 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway SNARE interactions in vesicular transport -0.448695652 -0.577075099 0 kegg kegg NA NA no no no no no no Ribosome SNARE interactions in vesicular transport 0 -0.760869565 0 kegg kegg NA NA no no no no no no RNA transport SNARE interactions in vesicular transport 0 -0.524703557 0 kegg kegg NA NA no no no no no no Selenocompound metabolism SNARE interactions in vesicular transport 0.409565217 0 0 kegg kegg NA NA no no no no no no Spliceosome SNARE interactions in vesicular transport 0 0.567193676 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism SNARE interactions in vesicular transport 0 0.507905138 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism SNARE interactions in vesicular transport 0.565217391 0.600790514 0.62960103 kegg kegg NA NA no no no no no no Thiamine metabolism SNARE interactions in vesicular transport 0.530434783 -0.419960474 0 kegg kegg NA NA no no no no no no Tyrosine metabolism SNARE interactions in vesicular transport 0 -0.451581028 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis SNARE interactions in vesicular transport 0.413043478 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis SNARE interactions in vesicular transport 0 -0.533596838 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor SNARE interactions in vesicular transport -0.520869565 0 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Sphingolipid metabolism 0 0 0.588931789 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Sphingolipid metabolism 0 0 0.483912484 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Sphingolipid metabolism 0 0.540513834 0.569369369 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Sphingolipid metabolism -0.593043478 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Sphingolipid metabolism 0 0 0.590733591 kegg kegg NA NA no no no no no no Galactose metabolism Sphingolipid metabolism 0 0 0.731531532 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Sphingolipid metabolism 0 0 -0.418532819 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Sphingolipid metabolism 0.58 0 0.541570142 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Sphingolipid metabolism 0 0 0.548777349 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Sphingolipid metabolism 0.843478261 0.566205534 0.751866152 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Sphingolipid metabolism -0.637391304 -0.54743083 0 kegg kegg NA NA no no no no no no Histidine metabolism Sphingolipid metabolism 0 0 0.510939511 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Sphingolipid metabolism -0.550434783 0 0 kegg kegg NA NA no no no no no no Other glycan degradation Sphingolipid metabolism 0 0 0.574259974 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Sphingolipid metabolism -0.483478261 0 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Sphingolipid metabolism 0.637391304 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Sphingolipid metabolism -0.406086957 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Sphingolipid metabolism 0 0 0.684684685 kegg kegg NA NA no no no no no no Steroid biosynthesis Sphingolipid metabolism -0.46173913 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Sphingolipid metabolism 0 0 0.403088803 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Sphingolipid metabolism -0.585217391 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Sphingolipid signaling pathway -0.706086957 0 0 kegg kegg NA NA no no no no no no ABC transporters Sphingolipid signaling pathway -0.479130435 0 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Sphingolipid signaling pathway -0.428695652 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Sphingolipid signaling pathway -0.602608696 -0.546442688 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Sphingolipid signaling pathway -0.631304348 -0.553359684 0 kegg kegg NA NA no no no no no no Antifolate resistance Sphingolipid signaling pathway -0.570434783 -0.519762846 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Sphingolipid signaling pathway -0.586956522 0 -0.625997426 kegg kegg NA NA no no no no no no Arginine and proline metabolism Sphingolipid signaling pathway 0 0.436758893 0 kegg kegg NA NA no up no no no no Basal transcription factors Sphingolipid signaling pathway 0 -0.463438735 0 kegg kegg NA NA no no no no no no Base excision repair Sphingolipid signaling pathway 0 -0.526679842 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Sphingolipid signaling pathway -0.673913043 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Sphingolipid signaling pathway 0 0.533596838 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Sphingolipid signaling pathway -0.794782609 -0.734189723 -0.695495495 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Sphingolipid signaling pathway -0.499130435 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Sphingolipid signaling pathway -0.774782609 -0.485177866 0 kegg kegg NA NA no no no no no no Butyricimonas Sphingolipid signaling pathway 0.55503849 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no Calcium signaling pathway Sphingolipid signaling pathway 0.545217391 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Sphingolipid signaling pathway 0.735652174 0.421936759 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Sphingolipid signaling pathway -0.536521739 0 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Sphingolipid signaling pathway 0.728695652 0.571146245 0.487258687 kegg kegg NA NA no no no no no no Chemokine signaling pathway Sphingolipid signaling pathway 0.539130435 0.549407115 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Sphingolipid signaling pathway -0.56 -0.473320158 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Sphingolipid signaling pathway 0.425217391 0 0 kegg kegg NA NA no no no no no no DNA replication Sphingolipid signaling pathway -0.408695652 -0.601778656 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Sphingolipid signaling pathway 0 -0.536561265 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Sphingolipid signaling pathway -0.537391304 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Sphingolipid signaling pathway 0 -0.460474308 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Sphingolipid signaling pathway 0.626956522 0 0.65045045 kegg kegg NA NA no no no no no no Ether lipid metabolism Sphingolipid signaling pathway 0 -0.550395257 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Sphingolipid signaling pathway 0 -0.635375494 0 kegg kegg NA NA no no no no no no Fatty acid elongation Sphingolipid signaling pathway -0.482608696 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Sphingolipid signaling pathway 0.433913043 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Sphingolipid signaling pathway -0.673043478 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Sphingolipid signaling pathway -0.565217391 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Sphingolipid signaling pathway -0.529565217 -0.473320158 -0.750836551 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Sphingolipid signaling pathway -0.61826087 -0.658102767 -0.654311454 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Sphingolipid signaling pathway -0.646086957 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Sphingolipid signaling pathway 0 0 0.48957529 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Sphingolipid signaling pathway 0 0 0.47979408 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Sphingolipid signaling pathway 0 0 0.420849421 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Sphingolipid signaling pathway 0 0.429841897 0.508622909 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Sphingolipid signaling pathway 0 -0.453557312 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Sphingolipid signaling pathway 0.430434783 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Sphingolipid signaling pathway 0 -0.697628458 0 kegg kegg NA NA no no no no no no Histidine metabolism Sphingolipid signaling pathway -0.454782609 0 0 kegg kegg NA NA no no no no no no Homologous recombination Sphingolipid signaling pathway 0 -0.557312253 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Sphingolipid signaling pathway 0 0 0.485456885 kegg kegg NA NA no no no no no no Linoleic acid metabolism Sphingolipid signaling pathway 0 -0.446640316 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Sphingolipid signaling pathway 0 0 0.686743887 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Sphingolipid signaling pathway 0 -0.470355731 0 kegg kegg NA NA no no no no no no Mismatch repair Sphingolipid signaling pathway -0.54 -0.623517787 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Sphingolipid signaling pathway 0.431304348 0 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Sphingolipid signaling pathway 0 0.414031621 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Sphingolipid signaling pathway 0 0.444664032 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Sphingolipid signaling pathway -0.611304348 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Sphingolipid signaling pathway 0 -0.683794466 0 kegg kegg NA NA no no no no no no One carbon pool by folate Sphingolipid signaling pathway -0.416521739 -0.673913043 0 kegg kegg NA NA no no no no no no Other glycan degradation Sphingolipid signaling pathway 0 0 0.435521236 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Sphingolipid signaling pathway 0 -0.420948617 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Sphingolipid signaling pathway 0.409565217 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Sphingolipid signaling pathway -0.503478261 -0.464426877 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Sphingolipid signaling pathway 0 0.584980237 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Sphingolipid signaling pathway -0.610434783 -0.464426877 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Sphingolipid signaling pathway 0.542608696 0 0.499099099 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Sphingolipid signaling pathway -0.610434783 -0.632411067 -0.734105534 kegg kegg NA NA no no no no no no PPAR signaling pathway Sphingolipid signaling pathway 0 0.634387352 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Sphingolipid signaling pathway -0.550434783 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Sphingolipid signaling pathway -0.446956522 0 0 kegg kegg NA NA no no no no no no Purine metabolism Sphingolipid signaling pathway -0.423478261 -0.622529644 -0.546718147 kegg kegg NA NA no no no no no no Pyrimidine metabolism Sphingolipid signaling pathway -0.565217391 -0.588932806 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Sphingolipid signaling pathway -0.519130435 -0.499011858 0 kegg kegg NA NA no no no no no no Ras signaling pathway Sphingolipid signaling pathway 0.520869565 0 0.483912484 yes kegg kegg NA NA no up up no no no Retinol metabolism Sphingolipid signaling pathway 0 -0.677865613 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Sphingolipid signaling pathway 0 -0.581027668 0 kegg kegg NA NA no no no no no no RNA degradation Sphingolipid signaling pathway 0.423478261 0 0 kegg kegg NA NA no no no no no no RNA polymerase Sphingolipid signaling pathway 0 -0.602766798 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Sphingolipid signaling pathway 0 -0.493083004 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Sphingolipid signaling pathway 0 0 0.511454311 kegg kegg NA NA no no no no no no Steroid biosynthesis Sphingolipid signaling pathway 0 -0.518774704 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Sphingolipid signaling pathway -0.487826087 -0.555335968 0 kegg kegg NA NA no no no no no no Sulfur metabolism Sphingolipid signaling pathway -0.582608696 0 -0.647104247 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Sphingolipid signaling pathway -0.466956522 -0.619565217 0 kegg kegg NA NA no no no no no no Thiamine metabolism Sphingolipid signaling pathway -0.468695652 -0.414031621 -0.414929215 kegg kegg NA NA no no no no no no Tryptophan metabolism Sphingolipid signaling pathway -0.670434783 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Sphingolipid signaling pathway -0.587826087 -0.627470356 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Sphingolipid signaling pathway -0.66173913 -0.658102767 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Sphingolipid signaling pathway -0.68 -0.596837945 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Sphingolipid signaling pathway 0 0 0.40952381 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Sphingolipid signaling pathway 0.448695652 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Spinocerebellar ataxia -0.436521739 0.597826087 0.496782497 kegg kegg NA NA no no no no no no Adherens junction Spinocerebellar ataxia -0.756521739 0 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Spinocerebellar ataxia 0 0 -0.579150579 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Spinocerebellar ataxia 0.464347826 0 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Spinocerebellar ataxia 0 -0.443675889 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Spinocerebellar ataxia 0 -0.498023715 -0.427799228 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Spinocerebellar ataxia 0 0.432806324 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Spinocerebellar ataxia 0.62173913 0 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Spinocerebellar ataxia -0.47826087 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Spinocerebellar ataxia 0.475652174 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Spinocerebellar ataxia -0.520869565 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Spinocerebellar ataxia 0 0.653162055 0.504761905 kegg kegg NA NA no no no no no no AMPK signaling pathway Spinocerebellar ataxia 0 0.429841897 -0.529214929 kegg kegg NA NA no no no no no no Antifolate resistance Spinocerebellar ataxia 0 0.542490119 0.401287001 kegg kegg NA NA no no no no no no Apelin signaling pathway Spinocerebellar ataxia 0.527826087 0 0.585328185 kegg kegg NA NA no no no no no no Apoptosis Spinocerebellar ataxia -0.552173913 -0.5 -0.518918919 kegg kegg NA NA no no no no no no Apoptosis - multiple species Spinocerebellar ataxia 0.455652174 0.41798419 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Spinocerebellar ataxia -0.486956522 -0.502964427 -0.720978121 kegg kegg NA NA no no no no no no Arginine and proline metabolism Spinocerebellar ataxia 0 -0.644268775 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Spinocerebellar ataxia 0 -0.565217391 -0.533333333 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Spinocerebellar ataxia 0 0 0.622908623 kegg kegg NA NA no no no no no no Autophagy - animal Spinocerebellar ataxia 0.68 0 0 kegg kegg NA NA no no no no no no Autophagy - other Spinocerebellar ataxia 0.866956522 0 0.723294723 kegg kegg NA NA no no no no no no Axon guidance Spinocerebellar ataxia 0.571304348 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Spinocerebellar ataxia 0 -0.491106719 0 kegg kegg NA NA no no no no no no Basal transcription factors Spinocerebellar ataxia 0.671304348 0.7243083 0.826769627 kegg kegg NA NA no no no no no no Base excision repair Spinocerebellar ataxia 0.439130435 0.703557312 0.621621622 kegg kegg NA NA no no no no no no beta-Alanine metabolism Spinocerebellar ataxia -0.653043478 0 0 kegg kegg NA NA no no no no no no Bile secretion Spinocerebellar ataxia 0 0 -0.656370656 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Spinocerebellar ataxia -0.555652174 -0.608695652 -0.55032175 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Spinocerebellar ataxia -0.413913043 0 -0.68957529 kegg kegg NA NA no no no no no no Butanoate metabolism Spinocerebellar ataxia 0 0.454545455 0 kegg kegg NA NA no no no no no no Butyricimonas Spinocerebellar ataxia 0.440738966 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no C-type lectin receptor signaling pathway Spinocerebellar ataxia 0.56 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Spinocerebellar ataxia 0.500869565 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Spinocerebellar ataxia 0.527826087 -0.447628458 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Spinocerebellar ataxia 0.594782609 0 0.457400257 kegg kegg NA NA no no no no no no Carbon metabolism Spinocerebellar ataxia -0.568695652 0 0 kegg kegg NA NA no no no no no no Cell cycle Spinocerebellar ataxia 0.416521739 0.834980237 0.715315315 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Spinocerebellar ataxia 0 -0.729249012 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Spinocerebellar ataxia 0 -0.666007905 -0.459202059 kegg kegg NA NA no no no no no no Cholinergic synapse Spinocerebellar ataxia 0.531304348 0 0 kegg kegg NA NA no no no no no no Circadian entrainment Spinocerebellar ataxia 0 0 -0.483140283 kegg kegg NA NA no up up no no no Circadian rhythm Spinocerebellar ataxia 0.850434783 0.837944664 0.738738739 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Spinocerebellar ataxia 0 0.433794466 0.715572716 kegg kegg NA NA no no no no no no Collecting duct acid secretion Spinocerebellar ataxia 0 -0.524703557 -0.46048906 kegg kegg NA NA no no no no no no Collinsella Spinocerebellar ataxia 0 0 -0.44443225 Genus kegg 0.128 NA no no no no no no Complement and coagulation cascades Spinocerebellar ataxia -0.495652174 -0.699604743 -0.584041184 kegg kegg NA NA no no no no no no Cushing syndrome Spinocerebellar ataxia 0 0.455533597 0 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Spinocerebellar ataxia 0 0.456521739 0.453024453 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Spinocerebellar ataxia 0 -0.544466403 0 kegg kegg NA NA no no no no no no DNA replication Spinocerebellar ataxia 0 0.677865613 0.727413127 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Spinocerebellar ataxia 0 0.418972332 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Spinocerebellar ataxia -0.492173913 0 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Spinocerebellar ataxia 0.546956522 0.449604743 0.507850708 kegg kegg NA NA no no no no no no ErbB signaling pathway Spinocerebellar ataxia 0.556521739 0 0.491377091 kegg kegg NA NA no no no no no no Estrogen signaling pathway Spinocerebellar ataxia 0 0.438735178 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Spinocerebellar ataxia 0 0 0.502445302 kegg kegg NA NA no no no no no no Fanconi anemia pathway Spinocerebellar ataxia 0 0.718379447 0.6998713 kegg kegg NA NA no no no no no no Fat digestion and absorption Spinocerebellar ataxia 0 -0.62055336 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Spinocerebellar ataxia 0 -0.485177866 0 kegg kegg NA NA no no no no no no Fatty acid elongation Spinocerebellar ataxia -0.54173913 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Spinocerebellar ataxia 0 -0.46541502 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Spinocerebellar ataxia 0 -0.622529644 0 kegg kegg NA NA no no no no no no Ferroptosis Spinocerebellar ataxia 0 -0.437747036 -0.592792793 kegg kegg NA NA no no no no no no Focal adhesion Spinocerebellar ataxia -0.720869565 0 0 kegg kegg NA NA no up up no no no Folate biosynthesis Spinocerebellar ataxia 0 0.612648221 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Spinocerebellar ataxia -0.576521739 0 0 kegg kegg NA NA no no no no no no GABAergic synapse Spinocerebellar ataxia 0 -0.576086957 -0.428056628 kegg kegg NA NA no up up no no no Galactose metabolism Spinocerebellar ataxia -0.684347826 0 0 kegg kegg NA NA no no no no no no Gap junction Spinocerebellar ataxia 0 0 -0.721492921 kegg kegg NA NA no no no no no no Gastric acid secretion Spinocerebellar ataxia -0.72 0 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Spinocerebellar ataxia 0 0.562252964 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Spinocerebellar ataxia 0 0 -0.700900901 kegg kegg NA NA no up up no no no Glutathione metabolism Spinocerebellar ataxia 0 0 -0.683140283 kegg kegg NA NA no no no no no no Glycerolipid metabolism Spinocerebellar ataxia 0 0 0.65997426 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Spinocerebellar ataxia 0 0 0.735392535 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Spinocerebellar ataxia 0 0 -0.733848134 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Spinocerebellar ataxia -0.483478261 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Spinocerebellar ataxia -0.475652174 0.611660079 0.621879022 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Spinocerebellar ataxia 0 0.508893281 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Spinocerebellar ataxia 0 -0.497035573 0.438610039 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Spinocerebellar ataxia 0 0.575098814 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Spinocerebellar ataxia 0 -0.565217391 -0.442471042 kegg kegg NA NA no no no no no no GnRH secretion Spinocerebellar ataxia 0.553043478 0 0.568597169 kegg kegg NA NA no up up no no no Hedgehog signaling pathway Spinocerebellar ataxia 0 0.847826087 0.706563707 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Spinocerebellar ataxia 0.542608696 0 0.472329472 kegg kegg NA NA no no no no no no Hippo signaling pathway Spinocerebellar ataxia -0.690434783 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Spinocerebellar ataxia 0 -0.464426877 0 kegg kegg NA NA no no no no no no Histidine metabolism Spinocerebellar ataxia -0.489565217 0 0 kegg kegg NA NA no no no no no no Homologous recombination Spinocerebellar ataxia 0 0.554347826 0.55032175 kegg kegg NA NA no no no no no no Huntington disease Spinocerebellar ataxia 0.456521739 0 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Spinocerebellar ataxia 0 -0.738142292 -0.403603604 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Spinocerebellar ataxia 0 0.431818182 0.614414414 kegg kegg NA NA no no no no no no Insulin resistance Spinocerebellar ataxia 0.723478261 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Spinocerebellar ataxia 0.580869565 0.425889328 0.628571429 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Spinocerebellar ataxia -0.56 0 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Spinocerebellar ataxia 0 0 0.405148005 kegg kegg NA NA no no no no no no Long-term depression Spinocerebellar ataxia 0 0 -0.566280566 kegg kegg NA NA no no no no no no Long-term potentiation Spinocerebellar ataxia 0.651304348 0 0.628314028 kegg kegg NA NA no no up no no no Longevity regulating pathway Spinocerebellar ataxia 0 0 -0.487516088 kegg kegg NA NA no no no no no no Lysine degradation Spinocerebellar ataxia 0.463478261 0.743083004 0.776833977 kegg kegg NA NA no no no no no no Lysosome Spinocerebellar ataxia 0 -0.688735178 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Spinocerebellar ataxia 0.426956522 0.659090909 0.695238095 kegg kegg NA NA no no no no no no MAPK signaling pathway Spinocerebellar ataxia 0 0 0.48983269 kegg kegg NA NA no no no no no no Mineral absorption Spinocerebellar ataxia 0 0 -0.472586873 kegg kegg NA NA no no no no no no Mismatch repair Spinocerebellar ataxia 0 0.473320158 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Spinocerebellar ataxia 0.692173913 0.732213439 0.728185328 kegg kegg NA NA no no no no no no mTOR signaling pathway Spinocerebellar ataxia 0.509565217 0.423913043 0.477477477 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Spinocerebellar ataxia 0.41826087 0.723320158 0.647876448 kegg kegg NA NA no no no no no no Necroptosis Spinocerebellar ataxia 0 0 -0.532818533 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Spinocerebellar ataxia 0 -0.616600791 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Spinocerebellar ataxia 0.593913043 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Spinocerebellar ataxia -0.509565217 -0.711462451 -0.576833977 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Spinocerebellar ataxia 0 -0.591897233 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Spinocerebellar ataxia 0 -0.618577075 -0.602831403 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Spinocerebellar ataxia 0.484347826 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Spinocerebellar ataxia -0.405217391 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Spinocerebellar ataxia 0 0 0.686743887 kegg kegg NA NA no no no no no no Nucleotide excision repair Spinocerebellar ataxia 0 0.622529644 0.549034749 kegg kegg NA NA no no no no no no Olfactory transduction Spinocerebellar ataxia 0 -0.743083004 0 kegg kegg NA NA no no no no no no One carbon pool by folate Spinocerebellar ataxia 0 0.636363636 0.641698842 kegg kegg NA NA no no no no no no Oocyte meiosis Spinocerebellar ataxia 0.557391304 0 0.631917632 kegg kegg NA NA no no no no no no Osteoclast differentiation Spinocerebellar ataxia 0 -0.539525692 -0.405920206 kegg kegg NA NA no no no no no no Other glycan degradation Spinocerebellar ataxia 0 0 0.552638353 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Spinocerebellar ataxia 0.522608696 0.644268775 0.715830116 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Spinocerebellar ataxia 0 0 -0.666666667 kegg kegg NA NA no up up no no no Oxytocin signaling pathway Spinocerebellar ataxia -0.770434783 -0.43083004 -0.644787645 kegg kegg NA NA no no no no no no p53 signaling pathway Spinocerebellar ataxia 0.616521739 0 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Spinocerebellar ataxia 0 -0.587944664 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Spinocerebellar ataxia 0.440869565 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Spinocerebellar ataxia 0 0.559288538 0.565250965 kegg kegg NA NA no no no no no no Pentose phosphate pathway Spinocerebellar ataxia -0.532173913 -0.701581028 -0.490604891 kegg kegg NA NA no no no no no no Peroxisome Spinocerebellar ataxia 0 -0.491106719 0 kegg kegg NA NA no no no no no no Phagosome Spinocerebellar ataxia -0.556521739 -0.506916996 -0.467181467 kegg kegg NA NA no no no no no no Phenylalanine metabolism Spinocerebellar ataxia -0.673913043 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Spinocerebellar ataxia 0.669565217 0.726284585 0.74980695 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Spinocerebellar ataxia 0 0.422924901 0.622651223 yes kegg kegg NA NA no up up no no no Platelet activation Spinocerebellar ataxia -0.786086957 0 -0.426254826 kegg kegg NA NA no no no no no no Platinum drug resistance Spinocerebellar ataxia 0.523478261 0.585968379 0.414157014 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Spinocerebellar ataxia 0 0 -0.711969112 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Spinocerebellar ataxia 0.674782609 0.677865613 0.827027027 kegg kegg NA NA no no no no no no Propanoate metabolism Spinocerebellar ataxia 0 0 0.447361647 kegg kegg NA NA no no no no no no Proteasome Spinocerebellar ataxia 0.62 0 0.463577864 kegg kegg NA NA no no no no no no Protein export Spinocerebellar ataxia 0.737391304 0.46541502 0.718661519 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Spinocerebellar ataxia 0 0.659090909 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Spinocerebellar ataxia 0 0.537549407 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Spinocerebellar ataxia -0.431304348 0.431818182 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Spinocerebellar ataxia 0 0.451581028 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Spinocerebellar ataxia -0.619130435 0 -0.415186615 kegg kegg NA NA no no no no no no Ras signaling pathway Spinocerebellar ataxia 0.414782609 0.444664032 0.624453024 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Spinocerebellar ataxia -0.546086957 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Spinocerebellar ataxia 0 0 -0.492921493 kegg kegg NA NA no no no no no no Renin secretion Spinocerebellar ataxia 0 0 -0.411840412 kegg kegg NA NA no no no no no no Renin-angiotensin system Spinocerebellar ataxia 0 -0.593873518 0 kegg kegg NA NA no no no no no no Retinol metabolism Spinocerebellar ataxia 0 0 0.56988417 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Spinocerebellar ataxia 0 0 0.405405405 kegg kegg NA NA no no up no no no Ribosome Spinocerebellar ataxia 0.537391304 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Spinocerebellar ataxia 0.526956522 0.859683794 0.814414414 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Spinocerebellar ataxia 0.506956522 0 0 kegg kegg NA NA no no no no no no RNA degradation Spinocerebellar ataxia 0.710434783 0.713438735 0.857142857 kegg kegg NA NA no no no no no no RNA polymerase Spinocerebellar ataxia 0.634782609 0.802371542 0.702187902 kegg kegg NA NA no no no no no no RNA transport Spinocerebellar ataxia 0 0.473320158 0 kegg kegg NA NA no no no no no no Salivary secretion Spinocerebellar ataxia 0 0 -0.586615187 kegg kegg NA NA no no no no no no Selenocompound metabolism Spinocerebellar ataxia 0.49826087 0.593873518 0.676705277 kegg kegg NA NA no no no no no no Serotonergic synapse Spinocerebellar ataxia 0 -0.5256917 -0.82960103 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Spinocerebellar ataxia 0.63826087 0.638339921 0.59047619 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Spinocerebellar ataxia 0.526086957 0 0.486229086 kegg kegg NA NA no no no no no no Spliceosome Spinocerebellar ataxia 0.597391304 0.668972332 0.695752896 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Spinocerebellar ataxia -0.454782609 -0.432806324 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Spinocerebellar ataxia 0 0 0.477477477 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Spinocerebellar ataxia -0.442608696 0 0.433976834 kegg kegg NA NA no no no no no no Sulfur metabolism Spinocerebellar ataxia -0.52 0 -0.697812098 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Spinocerebellar ataxia 0 -0.709486166 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Spinocerebellar ataxia 0 0.568181818 0.578120978 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Spinocerebellar ataxia 0.473043478 0 0.516344916 kegg kegg NA NA no no no no no no Taste transduction Spinocerebellar ataxia 0 0.571146245 0.718661519 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Spinocerebellar ataxia 0 0 0.442213642 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Spinocerebellar ataxia 0.467826087 0.502964427 0.76010296 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Spinocerebellar ataxia 0.431304348 0 0.583268983 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Spinocerebellar ataxia -0.610434783 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Spinocerebellar ataxia 0 0 -0.645302445 kegg kegg NA NA no no no no no no Tight junction Spinocerebellar ataxia -0.72173913 0 -0.404890605 kegg kegg NA NA no no no no no no TNF signaling pathway Spinocerebellar ataxia 0.568695652 0 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Spinocerebellar ataxia 0 -0.53458498 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Spinocerebellar ataxia -0.41826087 0 0.487516088 kegg kegg NA NA no up no no no no Type II diabetes mellitus Spinocerebellar ataxia 0.592173913 0 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Spinocerebellar ataxia -0.489565217 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Spinocerebellar ataxia 0 0.446640316 0.521235521 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Spinocerebellar ataxia 0 0.451581028 0.515830116 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Spinocerebellar ataxia 0.590434783 0.741106719 0.706048906 kegg kegg NA NA no no no no no no VEGF signaling pathway Spinocerebellar ataxia 0.54173913 0 0.533590734 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Spinocerebellar ataxia 0 -0.768774704 -0.403603604 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Spinocerebellar ataxia 0 0 0.526383526 kegg kegg NA NA no no no no no no Wnt signaling pathway Spinocerebellar ataxia 0 0.739130435 0.772972973 kegg kegg NA NA no no no no no no ABC transporters Spliceosome 0.424347826 0.789525692 0 kegg kegg NA NA no up up no no no Amino sugar and nucleotide sugar metabolism Spliceosome 0 0.437747036 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Spliceosome 0.490434783 0.564229249 0.55006435 kegg kegg NA NA no no no no no no Anaerostipes Spliceosome 0 0.532543849 0 butyrate-producing Genus kegg 0.568 NA no no no no no no Antifolate resistance Spliceosome 0 0.45256917 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Spliceosome 0 0 -0.661776062 kegg kegg NA NA no no no no no no Arginine biosynthesis Spliceosome 0 0 -0.542342342 kegg kegg NA NA no no no no no no Basal transcription factors Spliceosome 0.794782609 0.625494071 0.791505792 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Spliceosome 0 0 -0.693178893 kegg kegg NA NA no no no no no no Carbon metabolism Spliceosome 0 -0.574110672 -0.511969112 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Spliceosome 0 0 0.410810811 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Spliceosome 0.485217391 0 0.61981982 kegg kegg NA NA no no no no no no DNA replication Spliceosome 0.665217391 0 0.623423423 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Spliceosome 0.617391304 0 0.484684685 kegg kegg NA NA no no no no no no Glutathione metabolism Spliceosome 0 0 -0.482625483 kegg kegg NA NA no no no no no no Glycerolipid metabolism Spliceosome 0 0.683794466 0.464092664 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Spliceosome 0 0.716403162 0.614414414 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Spliceosome -0.64173913 0 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Spliceosome 0 0.447628458 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Spliceosome 0.626956522 0.548418972 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Spliceosome 0 0 -0.56010296 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Spliceosome 0 0.782608696 0.563449163 kegg kegg NA NA no no no no no no Lachnospira Spliceosome 0 -0.603904145 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Lysine degradation Spliceosome 0.707826087 0.884387352 0.745173745 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Spliceosome 0 0.700592885 0.656628057 kegg kegg NA NA no no no no no no mRNA surveillance pathway Spliceosome 0 0.443675889 0.794337194 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Spliceosome 0 0.621541502 0.433976834 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Spliceosome 0.55826087 0 0.719433719 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Spliceosome 0 0 -0.512998713 kegg kegg NA NA no no no no no no Nitrogen metabolism Spliceosome 0 0 -0.522265122 kegg kegg NA NA no no no no no no One carbon pool by folate Spliceosome 0.553913043 0 0.621879022 kegg kegg NA NA no no no no no no Oscillospira Spliceosome 0 0.45256917 0 LPS-producing Genus kegg 0.62 NA no no no no no no Other glycan degradation Spliceosome 0 0.659090909 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Spliceosome 0.646086957 0.864624506 0.796396396 kegg kegg NA NA no no no no no no Parabacteroides Spliceosome 0 0 -0.487418754 Genus kegg 4.19E-05 NA no up up no no no Pentose and glucuronate interconversions Spliceosome 0 0 0.483655084 kegg kegg NA NA no no no no no no Pentose phosphate pathway Spliceosome -0.508695652 -0.589920949 -0.697297297 kegg kegg NA NA no no no no no no Platinum drug resistance Spliceosome 0.803478261 0.899209486 0.646332046 kegg kegg NA NA no no no no no no Propanoate metabolism Spliceosome 0.448695652 0 0.498841699 kegg kegg NA NA no no no no no no Pyruvate metabolism Spliceosome 0.443478261 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Spliceosome 0.855652174 0.657114625 0.86975547 kegg kegg NA NA no no no no no no RNA degradation Spliceosome 0 0 0.84015444 kegg kegg NA NA no no no no no no RNA polymerase Spliceosome 0.812173913 0.538537549 0.554440154 kegg kegg NA NA no no no no no no RNA transport Spliceosome 0.743478261 0 0.547490347 kegg kegg NA NA no no no no no no Roseburia Spliceosome -0.485217391 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Selenocompound metabolism Spliceosome 0.740869565 0.793478261 0.662290862 kegg kegg NA NA no no no no no no Sphingolipid metabolism Spliceosome -0.653913043 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Spliceosome 0 0 -0.516087516 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Spliceosome 0.476521739 0 0.519433719 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Spliceosome 0.431304348 0.670948617 0.429086229 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Spliceosome 0.597391304 0.468379447 0.564478764 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Spliceosome 0 0 0.41029601 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Spliceosome 0 0 0.40978121 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Spliceosome 0.645217391 0 0.718146718 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Staphylococcus aureus infection -0.589565217 -0.621541502 -0.538738739 kegg kegg NA NA no no up up no no AGE-RAGE signaling pathway in diabetic complications Staphylococcus aureus infection 0 0.46541502 0 kegg kegg NA NA no no no up no no "Alanine, aspartate and glutamate metabolism" Staphylococcus aureus infection 0 0 0.490604891 kegg kegg NA NA no no no up no no Aldosterone synthesis and secretion Staphylococcus aureus infection -0.562608696 -0.754940711 -0.484684685 kegg kegg NA NA no up up up no no alpha-Linolenic acid metabolism Staphylococcus aureus infection 0.426086957 0 0 kegg kegg NA NA no no no up no no Alzheimer disease Staphylococcus aureus infection -0.588695652 -0.4743083 0 kegg kegg NA NA no no no up no no Amoebiasis Staphylococcus aureus infection 0 0 0.61003861 kegg kegg NA NA no no no up no no Amphetamine addiction Staphylococcus aureus infection -0.639130435 -0.73715415 0 kegg kegg NA NA no no no up no no AMPK signaling pathway Staphylococcus aureus infection 0 -0.782608696 0 kegg kegg NA NA no no no up no no Amyotrophic lateral sclerosis Staphylococcus aureus infection -0.56 -0.524703557 0 kegg kegg NA NA no no no up no no Antifolate resistance Staphylococcus aureus infection 0 -0.545454545 -0.440669241 kegg kegg NA NA no no no up no no Antigen processing and presentation Staphylococcus aureus infection 0 0.503952569 0.563191763 kegg kegg NA NA no no no up no no Apelin signaling pathway Staphylococcus aureus infection -0.589565217 0 0 kegg kegg NA NA no no no up no no Apoptosis Staphylococcus aureus infection 0.555652174 0.611660079 0.657400257 kegg kegg NA NA no no no up no no Arginine and proline metabolism Staphylococcus aureus infection 0 0.506916996 0.413384813 kegg kegg NA NA no up no up no no Arginine biosynthesis Staphylococcus aureus infection 0 0 0.577091377 kegg kegg NA NA no no no up no no Autophagy - other Staphylococcus aureus infection -0.526956522 0 -0.584555985 kegg kegg NA NA no no no up no no B cell receptor signaling pathway Staphylococcus aureus infection 0 0.479249012 0 kegg kegg NA NA no no no up no no Bacterial invasion of epithelial cells Staphylococcus aureus infection 0.52 0 0 kegg kegg NA NA no no no up no no Basal transcription factors Staphylococcus aureus infection -0.415652174 -0.595849802 -0.684427284 kegg kegg NA NA no no no up no no Base excision repair Staphylococcus aureus infection 0 -0.595849802 -0.455341055 kegg kegg NA NA no no no up no no beta-Alanine metabolism Staphylococcus aureus infection 0.606086957 0 0 kegg kegg NA NA no no no up no no Biosynthesis of amino acids Staphylococcus aureus infection 0.652173913 0.711462451 0.843500644 kegg kegg NA NA no no no up no no Biosynthesis of cofactors Staphylococcus aureus infection 0 -0.651185771 0 kegg kegg NA NA no no no up no no C-type lectin receptor signaling pathway Staphylococcus aureus infection 0 0.485177866 0 kegg kegg NA NA no no no up no no Calcium signaling pathway Staphylococcus aureus infection -0.447826087 -0.48715415 -0.50990991 kegg kegg NA NA no up up up no no cAMP signaling pathway Staphylococcus aureus infection -0.583478261 0 0 yes kegg kegg NA NA no up up up no no Carbon metabolism Staphylococcus aureus infection 0.58173913 0.670948617 0.785585586 kegg kegg NA NA no no no up no no Cardiac muscle contraction Staphylococcus aureus infection -0.494782609 -0.454545455 0 kegg kegg NA NA no no up up no no Cell adhesion molecules Staphylococcus aureus infection 0.602608696 0.77173913 0.506563707 kegg kegg NA NA no no no up no no Cell cycle Staphylococcus aureus infection -0.445217391 -0.709486166 -0.703732304 kegg kegg NA NA no no no up no no Cellular senescence Staphylococcus aureus infection 0 0.632411067 0 kegg kegg NA NA no no no up no no cGMP-PKG signaling pathway Staphylococcus aureus infection 0 0.774703557 0 kegg kegg NA NA no no no up no no Chemokine signaling pathway Staphylococcus aureus infection 0 0.518774704 0 kegg kegg NA NA no no no up no no Cholesterol metabolism Staphylococcus aureus infection 0 0.666007905 0 yes kegg kegg NA NA no no up up no no Circadian rhythm Staphylococcus aureus infection -0.657391304 -0.761857708 -0.809266409 kegg kegg NA NA no no no up no no Clostridium Staphylococcus aureus infection 0 0.445217992 0 Genus kegg 0.925 NA no no no up no no Cocaine addiction Staphylococcus aureus infection -0.432173913 -0.721343874 0 kegg kegg NA NA no no no up no no Collecting duct acid secretion Staphylococcus aureus infection 0 0 0.403088803 kegg kegg NA NA no no no up no no Complement and coagulation cascades Staphylococcus aureus infection 0.528695652 0.755928854 0.781981982 kegg kegg NA NA no no no up no no Cortisol synthesis and secretion Staphylococcus aureus infection -0.511304348 -0.788537549 0 kegg kegg NA NA no no up up no no Cushing syndrome Staphylococcus aureus infection -0.563478261 -0.875494071 -0.563449163 kegg kegg NA NA no no up up no no Cytokine-cytokine receptor interaction Staphylococcus aureus infection 0 0.414031621 0 kegg kegg NA NA no no no up no no DNA replication Staphylococcus aureus infection 0 -0.486166008 -0.568082368 kegg kegg NA NA no no no up no no Dopaminergic synapse Staphylococcus aureus infection -0.651304348 -0.498023715 -0.439382239 kegg kegg NA NA no up no up no no Drug metabolism - other enzymes Staphylococcus aureus infection 0.432173913 0 0 kegg kegg NA NA no no no up no no EGFR tyrosine kinase inhibitor resistance Staphylococcus aureus infection -0.50173913 0 0 kegg kegg NA NA no no no up no no Endocrine and other factor-regulated calcium reabsorption Staphylococcus aureus infection 0 -0.666007905 0 kegg kegg NA NA no no no up no no Endocrine resistance Staphylococcus aureus infection -0.487826087 -0.671936759 0 kegg kegg NA NA no no no up no no Endocytosis Staphylococcus aureus infection 0.453043478 0.769762846 0 kegg kegg NA NA no no no up no no Epithelial cell signaling in Helicobacter pylori infection Staphylococcus aureus infection 0 0.623517787 0 kegg kegg NA NA no no no up no no Ether lipid metabolism Staphylococcus aureus infection -0.468695652 -0.566205534 -0.514800515 kegg kegg NA NA no no no up no no Faecalibacterium Staphylococcus aureus infection -0.405217391 0 0 butyrate-producing Genus kegg 0.0039 NA no dn dn up no no Fanconi anemia pathway Staphylococcus aureus infection 0 -0.606719368 -0.563449163 kegg kegg NA NA no no no up no no Fat digestion and absorption Staphylococcus aureus infection 0 0.635375494 0.496782497 yes kegg kegg NA NA no up up up no no Fatty acid biosynthesis Staphylococcus aureus infection 0 0.453557312 0 kegg kegg NA NA no no no up no no Fatty acid elongation Staphylococcus aureus infection 0.63826087 0 0 kegg kegg NA NA no no no up no no Fatty acid metabolism Staphylococcus aureus infection 0.572173913 0.489130435 0 kegg kegg NA NA no no no up no no Fc epsilon RI signaling pathway Staphylococcus aureus infection 0 0.589920949 0 kegg kegg NA NA no no no up no no Fc gamma R-mediated phagocytosis Staphylococcus aureus infection 0.64 0.874505929 0.806177606 kegg kegg NA NA no no no up no no Focal adhesion Staphylococcus aureus infection 0.419130435 0 0 kegg kegg NA NA no up up up no no GABAergic synapse Staphylococcus aureus infection 0 0 0.406949807 kegg kegg NA NA no up up up no no Galactose metabolism Staphylococcus aureus infection 0.633043478 0 0 kegg kegg NA NA no no no up no no Gemmiger Staphylococcus aureus infection -0.417047194 0 0 butyrate-producing Genus kegg 0.595 NA no no no up no no Glucagon signaling pathway Staphylococcus aureus infection -0.693043478 -0.783596838 -0.657400257 kegg kegg NA NA no no no up no no Glutathione metabolism Staphylococcus aureus infection 0 -0.577075099 0 kegg kegg NA NA no no no up no no Glycerolipid metabolism Staphylococcus aureus infection 0 0 -0.503474903 kegg kegg NA NA no no up up no no Glycerophospholipid metabolism Staphylococcus aureus infection 0 0 -0.608494208 kegg kegg NA NA no no up up no no "Glycine, serine and threonine metabolism" Staphylococcus aureus infection 0 -0.621541502 0 kegg kegg NA NA no up no up no no Glycolysis / Gluconeogenesis Staphylococcus aureus infection 0 0 0.492664093 kegg kegg NA NA no no no up no no Glycosaminoglycan biosynthesis - keratan sulfate Staphylococcus aureus infection 0 0 -0.570913771 kegg kegg NA NA no no no up no no Glycosaminoglycan degradation Staphylococcus aureus infection 0 0.721343874 0 kegg kegg NA NA no no up up no no Glycosphingolipid biosynthesis - lacto and neolacto series Staphylococcus aureus infection 0 0 -0.487258687 kegg kegg NA NA no no no up no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Staphylococcus aureus infection 0 -0.653162055 -0.484427284 kegg kegg NA NA no no no up no no Glyoxylate and dicarboxylate metabolism Staphylococcus aureus infection 0.499130435 0.443675889 0.588159588 kegg kegg NA NA no no no up no no GnRH secretion Staphylococcus aureus infection 0 0 -0.409266409 kegg kegg NA NA no up up up no no GnRH signaling pathway Staphylococcus aureus infection -0.437391304 -0.66798419 0 kegg kegg NA NA no no no up no no "Growth hormone synthesis, secretion and action" Staphylococcus aureus infection -0.406086957 0 0 kegg kegg NA NA no no no up no no Hedgehog signaling pathway Staphylococcus aureus infection 0 -0.593873518 -0.662290862 kegg kegg NA NA no no no up no no HIF-1 signaling pathway Staphylococcus aureus infection -0.443478261 0 0 kegg kegg NA NA no no no up no no Homologous recombination Staphylococcus aureus infection 0 -0.503952569 -0.506048906 kegg kegg NA NA no no no up no no Huntington disease Staphylococcus aureus infection -0.549565217 -0.498023715 0 kegg kegg NA NA no no no up no no IL-17 signaling pathway Staphylococcus aureus infection 0 0.792490119 0.595624196 kegg kegg NA NA no no no up no no Inflammatory mediator regulation of TRP channels Staphylococcus aureus infection -0.51826087 -0.539525692 -0.429086229 kegg kegg NA NA no no no up no no Inositol phosphate metabolism Staphylococcus aureus infection 0 0 -0.493693694 kegg kegg NA NA no no no up no no Insulin resistance Staphylococcus aureus infection -0.484347826 0 -0.47001287 kegg kegg NA NA no no no up no no Insulin secretion Staphylococcus aureus infection -0.413913043 -0.767786561 0 yes kegg kegg NA NA no up up up no no Insulin signaling pathway Staphylococcus aureus infection -0.58 0 0 kegg kegg NA NA no no no up no no Intestinal immune network for IgA production Staphylococcus aureus infection 0 0 0.403861004 kegg kegg NA NA no no no up no no Leishmaniasis Staphylococcus aureus infection 0 0 0.509395109 kegg kegg NA NA no no no up no no Leukocyte transendothelial migration Staphylococcus aureus infection 0.474782609 0.532608696 0.638352638 kegg kegg NA NA no no no up no no Long-term potentiation Staphylococcus aureus infection -0.55826087 0 -0.44015444 kegg kegg NA NA no no up up no no Longevity regulating pathway Staphylococcus aureus infection 0 -0.483201581 0 kegg kegg NA NA no no no up no no Lysine degradation Staphylococcus aureus infection 0 -0.602766798 -0.699356499 kegg kegg NA NA no no no up no no Lysosome Staphylococcus aureus infection 0.510434783 0.918972332 0.674646075 kegg kegg NA NA no no no up no no Mannose type O-glycan biosynthesis Staphylococcus aureus infection 0 -0.472332016 -0.718404118 kegg kegg NA NA no no no up no no Melanogenesis Staphylococcus aureus infection -0.422608696 -0.57312253 -0.418275418 kegg kegg NA NA no no no up no no Mineral absorption Staphylococcus aureus infection -0.453913043 -0.481225296 0 kegg kegg NA NA no no no up no no Mitophagy - animal Staphylococcus aureus infection -0.624347826 -0.593873518 0 kegg kegg NA NA no no no up no no Morphine addiction Staphylococcus aureus infection 0 -0.584980237 0 kegg kegg NA NA no up up up no no mRNA surveillance pathway Staphylococcus aureus infection -0.590434783 -0.682806324 -0.841956242 kegg kegg NA NA no no no up no no mTOR signaling pathway Staphylococcus aureus infection -0.54 0 0 kegg kegg NA NA no no no up no no N-Glycan biosynthesis Staphylococcus aureus infection -0.426956522 -0.495059289 -0.54980695 kegg kegg NA NA no no no up no no Natural killer cell mediated cytotoxicity Staphylococcus aureus infection 0.493913043 0.705533597 0 kegg kegg NA NA no no no up no no Necroptosis Staphylococcus aureus infection -0.457391304 0 0 kegg kegg NA NA no no no up no no Neuroactive ligand-receptor interaction Staphylococcus aureus infection 0.406956522 0.903162055 0.708622909 kegg kegg NA NA up up up up no no Neutrophil extracellular trap formation Staphylococcus aureus infection 0.707826087 0.852766798 0.855341055 kegg kegg NA NA no no no up no no Nicotinate and nicotinamide metabolism Staphylococcus aureus infection 0 0.53458498 0.499099099 kegg kegg NA NA no no no up no no Nicotine addiction Staphylococcus aureus infection 0 -0.484189723 0 kegg kegg NA NA no up up up no no Nitrogen metabolism Staphylococcus aureus infection 0 0 0.435263835 kegg kegg NA NA no no no up no no NOD-like receptor signaling pathway Staphylococcus aureus infection 0 0.502964427 0 kegg kegg NA NA no no no up no no Non-alcoholic fatty liver disease Staphylococcus aureus infection -0.620869565 -0.480237154 0 kegg kegg NA NA no no no up no no Notch signaling pathway Staphylococcus aureus infection 0 0 -0.553410553 kegg kegg NA NA no no no up no no Nucleotide excision repair Staphylococcus aureus infection 0 -0.543478261 -0.482625483 kegg kegg NA NA no no no up no no Olfactory transduction Staphylococcus aureus infection 0 0.739130435 0.614929215 kegg kegg NA NA no no no up no no One carbon pool by folate Staphylococcus aureus infection 0 -0.526679842 -0.533075933 kegg kegg NA NA no no no up no no Oocyte meiosis Staphylococcus aureus infection -0.513913043 0 -0.450707851 kegg kegg NA NA no no no up no no Osteoclast differentiation Staphylococcus aureus infection 0.475652174 0.736166008 0.598198198 kegg kegg NA NA no no no up no no Other types of O-glycan biosynthesis Staphylococcus aureus infection -0.524347826 -0.668972332 -0.682882883 kegg kegg NA NA no no no up no no Ovarian steroidogenesis Staphylococcus aureus infection 0 -0.5256917 0 kegg kegg NA NA no up up up no no Oxidative phosphorylation Staphylococcus aureus infection -0.52173913 -0.435770751 0 kegg kegg NA NA no no no up no no Oxytocin signaling pathway Staphylococcus aureus infection 0 0 0.613384813 kegg kegg NA NA no no no up no no p53 signaling pathway Staphylococcus aureus infection -0.459130435 -0.515810277 -0.633976834 kegg kegg NA NA no no no up no no Pancreatic secretion Staphylococcus aureus infection 0 -0.459486166 0 kegg kegg NA NA no no no up no no Pantothenate and CoA biosynthesis Staphylococcus aureus infection 0 0.627470356 0.492406692 kegg kegg NA NA no no dn up no no "Parathyroid hormone synthesis, secretion and action" Staphylococcus aureus infection -0.726086957 -0.556324111 0 kegg kegg NA NA no no no up no no Parkinson disease Staphylococcus aureus infection -0.635652174 -0.503952569 0 kegg kegg NA NA no no no up no no Pathogenic Escherichia coli infection Staphylococcus aureus infection 0.56 0.792490119 0.715315315 kegg kegg NA NA no no no up no no Pathways of neurodegeneration - multiple diseases Staphylococcus aureus infection -0.631304348 -0.545454545 0 kegg kegg NA NA no no no up no no Pentose phosphate pathway Staphylococcus aureus infection 0.62173913 0.878458498 0.754182754 kegg kegg NA NA no no no up no no Peroxisome Staphylococcus aureus infection 0.415652174 0.553359684 0.517631918 kegg kegg NA NA no no no up no no Pertussis Staphylococcus aureus infection 0.62 0.841897233 0.848906049 kegg kegg NA NA no no dn up no no Phagosome Staphylococcus aureus infection 0.705217391 0.866600791 0.720720721 kegg kegg NA NA no no no up no no Phosphatidylinositol signaling system Staphylococcus aureus infection -0.454782609 0 -0.737709138 kegg kegg NA NA no no no up no no PI3K-Akt signaling pathway Staphylococcus aureus infection -0.490434783 0 0 yes kegg kegg NA NA no up up up no no Platinum drug resistance Staphylococcus aureus infection 0 0 -0.42007722 kegg kegg NA NA no no no up no no Porphyrin and chlorophyll metabolism Staphylococcus aureus infection 0 -0.595849802 0 kegg kegg NA NA no no no up no no PPAR signaling pathway Staphylococcus aureus infection 0 0.538537549 0.497039897 kegg kegg NA NA no no no up no no Primary bile acid biosynthesis Staphylococcus aureus infection 0 0 0.483655084 kegg kegg NA NA no no no up no no Prion disease Staphylococcus aureus infection -0.531304348 0 0 kegg kegg NA NA no no no up no no Progesterone-mediated oocyte maturation Staphylococcus aureus infection -0.437391304 -0.437747036 -0.517374517 kegg kegg NA NA no no no up no no Prolactin signaling pathway Staphylococcus aureus infection 0 0.429841897 0 kegg kegg NA NA no no no up no no Protein digestion and absorption Staphylococcus aureus infection 0.527826087 0.608695652 0 yes kegg kegg NA NA no up up up no no Protein export Staphylococcus aureus infection -0.624347826 0 -0.56988417 kegg kegg NA NA no no no up no no Protein processing in endoplasmic reticulum Staphylococcus aureus infection -0.480869565 -0.663043478 0 kegg kegg NA NA no no no up no no Purine metabolism Staphylococcus aureus infection 0 -0.752964427 0 kegg kegg NA NA no no no up no no Pyrimidine metabolism Staphylococcus aureus infection 0.422608696 -0.448616601 0 kegg kegg NA NA no no no up no no Ras signaling pathway Staphylococcus aureus infection 0 0 -0.611840412 yes kegg kegg NA NA no up up up no no Regulation of lipolysis in adipocytes Staphylococcus aureus infection -0.472173913 -0.546442688 0 kegg kegg NA NA no no no up no no Relaxin signaling pathway Staphylococcus aureus infection -0.550434783 0 0 kegg kegg NA NA no no no up no no Renin secretion Staphylococcus aureus infection 0 -0.442687747 0 kegg kegg NA NA no no no up no no Renin-angiotensin system Staphylococcus aureus infection 0.439130435 0.898221344 0.431145431 kegg kegg NA NA no no no up no no Retrograde endocannabinoid signaling Staphylococcus aureus infection -0.409565217 0 0 kegg kegg NA NA no no up up no no Ribosome Staphylococcus aureus infection -0.723478261 0 0 kegg kegg NA NA no no no up no no Ribosome biogenesis in eukaryotes Staphylococcus aureus infection -0.451304348 -0.668972332 -0.688545689 kegg kegg NA NA no no no up no no RNA degradation Staphylococcus aureus infection -0.50173913 -0.561264822 -0.691891892 kegg kegg NA NA no no no up no no RNA polymerase Staphylococcus aureus infection -0.548695652 -0.720355731 -0.58996139 kegg kegg NA NA no no no up no no Salmonella infection Staphylococcus aureus infection 0.520869565 0.78458498 0.697812098 kegg kegg NA NA no no no up no no Selenocompound metabolism Staphylococcus aureus infection 0 -0.522727273 -0.515572716 kegg kegg NA NA no no no up no no Serotonergic synapse Staphylococcus aureus infection 0 0 0.42007722 kegg kegg NA NA no no no up no no Shigellosis Staphylococcus aureus infection -0.459130435 0 0 kegg kegg NA NA no no no up no no Signaling pathways regulating pluripotency of stem cells Staphylococcus aureus infection -0.566956522 -0.451581028 -0.625997426 kegg kegg NA NA no no no up no no Sphingolipid signaling pathway Staphylococcus aureus infection 0 0.624505929 0 kegg kegg NA NA no no no up no no Spinocerebellar ataxia Staphylococcus aureus infection -0.573043478 -0.563241107 -0.573487773 kegg kegg NA NA no no no up no no Spliceosome Staphylococcus aureus infection -0.448695652 -0.510869565 -0.612612613 kegg kegg NA NA no no no up no no Starch and sucrose metabolism Staphylococcus aureus infection 0 0.5 0.401544402 kegg kegg NA NA no no no up no no Steroid biosynthesis Staphylococcus aureus infection -0.430434783 0 0 kegg kegg NA NA no no no up no no Synaptic vesicle cycle Staphylococcus aureus infection 0 0.770750988 0.47979408 kegg kegg NA NA no up up up no no Taste transduction Staphylococcus aureus infection -0.412173913 -0.539525692 -0.597168597 kegg kegg NA NA no no up up no no Taurine and hypotaurine metabolism Staphylococcus aureus infection 0 0 -0.541312741 kegg kegg NA NA no no no up no no Terpenoid backbone biosynthesis Staphylococcus aureus infection 0 0 -0.523294723 kegg kegg NA NA no no no up no no TGF-beta signaling pathway Staphylococcus aureus infection 0 0 -0.45045045 kegg kegg NA NA no no no up no no Th1 and Th2 cell differentiation Staphylococcus aureus infection 0 0.441699605 0 kegg kegg NA NA no no no up no no Thermogenesis Staphylococcus aureus infection -0.542608696 -0.460474308 0 kegg kegg NA NA no no no up no no Thyroid hormone synthesis Staphylococcus aureus infection 0 -0.719367589 0 kegg kegg NA NA no no no up no no Tight junction Staphylococcus aureus infection 0.42173913 0 0.577863578 kegg kegg NA NA no no no up no no Toll-like receptor signaling pathway Staphylococcus aureus infection 0 0.517786561 0 yes kegg kegg NA NA no no no up no no Toxoplasmosis Staphylococcus aureus infection 0.46 0.684782609 0.555469755 kegg kegg NA NA no no no up no no Type I diabetes mellitus Staphylococcus aureus infection 0.569565217 0.72826087 0 kegg kegg NA NA no no no up no no Ubiquinone and other terpenoid-quinone biosynthesis Staphylococcus aureus infection 0 0 -0.482882883 kegg kegg NA NA no no no up no no Ubiquitin mediated proteolysis Staphylococcus aureus infection -0.610434783 -0.68083004 0 kegg kegg NA NA no no no up no no Various types of N-glycan biosynthesis Staphylococcus aureus infection -0.530434783 0 -0.401029601 kegg kegg NA NA no no no up no no Vascular smooth muscle contraction Staphylococcus aureus infection -0.545217391 0 0 kegg kegg NA NA no no no up no no Vasopressin-regulated water reabsorption Staphylococcus aureus infection -0.433043478 -0.577075099 0 kegg kegg NA NA no no no up no no Viral protein interaction with cytokine and cytokine receptor Staphylococcus aureus infection 0 0.438735178 0 kegg kegg NA NA no no no up no no Wnt signaling pathway Staphylococcus aureus infection 0 -0.567193676 -0.717374517 kegg kegg NA NA no no no up no no Yersinia infection Staphylococcus aureus infection 0.48173913 0.796442688 0.493436293 kegg kegg NA NA no no no up no no "Alanine, aspartate and glutamate metabolism" Starch and sucrose metabolism 0.584347826 0.828063241 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Starch and sucrose metabolism 0.770434783 0.749011858 0.510682111 kegg kegg NA NA no up no no no no Arginine biosynthesis Starch and sucrose metabolism 0.672173913 0.776679842 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Starch and sucrose metabolism 0 0 0.431145431 kegg kegg NA NA no no no no no no beta-Alanine metabolism Starch and sucrose metabolism 0.48 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Starch and sucrose metabolism 0 -0.486166008 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Starch and sucrose metabolism 0 -0.550395257 -0.435006435 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Starch and sucrose metabolism 0.555652174 0.897233202 0 kegg kegg NA NA no no no no no no Fatty acid degradation Starch and sucrose metabolism 0.643478261 0.803359684 0.513256113 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Starch and sucrose metabolism 0.68173913 0.508893281 0.776833977 kegg kegg NA NA no no no no no no Galactose metabolism Starch and sucrose metabolism 0.712173913 0.840909091 0.780952381 kegg kegg NA NA no no no no no no Glutathione metabolism Starch and sucrose metabolism 0 -0.736166008 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Starch and sucrose metabolism 0 -0.445652174 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Starch and sucrose metabolism 0.448695652 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Starch and sucrose metabolism 0.586086957 0.41798419 0.586615187 kegg kegg NA NA no no no no no no Oxidative phosphorylation Starch and sucrose metabolism -0.44173913 -0.799407115 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Starch and sucrose metabolism 0 -0.644268775 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Starch and sucrose metabolism 0.728695652 0.659090909 0.625482625 kegg kegg NA NA no no no no no no Purine metabolism Starch and sucrose metabolism 0 -0.509881423 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Starch and sucrose metabolism 0.473043478 -0.464426877 0.411840412 kegg kegg NA NA no no no no no no Steroid biosynthesis Starch and sucrose metabolism -0.435652174 0 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Steroid biosynthesis 0 0.505928854 0.454826255 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Steroid biosynthesis 0 0.760869565 0.609266409 kegg kegg NA NA no no no no no no Fatty acid elongation Steroid biosynthesis 0 0.563241107 0.492664093 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Steroid biosynthesis 0 0.540513834 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Steroid biosynthesis 0 0.649209486 0.498069498 kegg kegg NA NA no no no no no no Pentose phosphate pathway Steroid biosynthesis -0.633043478 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Steroid biosynthesis 0.480869565 0.855731225 0.689060489 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Steroid hormone biosynthesis 0.622608696 0.584980237 0.609009009 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Steroid hormone biosynthesis 0.653043478 0.744071146 0.601544402 kegg kegg NA NA no no no no no no Fatty acid elongation Steroid hormone biosynthesis 0.736521739 0.606719368 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Steroid hormone biosynthesis 0.439130435 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Steroid hormone biosynthesis 0.486086957 0 0.533848134 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Steroid hormone biosynthesis 0.613913043 0.511857708 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Steroid hormone biosynthesis 0.74 0.664031621 0.429343629 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Steroid hormone biosynthesis 0.779130435 0.710474308 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Steroid hormone biosynthesis 0 0.817193676 0.552123552 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Steroid hormone biosynthesis 0.56 0.739130435 0.445559846 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Steroid hormone biosynthesis 0.705217391 0.789525692 0.537709138 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Sulfur metabolism 0 0 0.491891892 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Sulfur metabolism 0.426956522 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Sulfur metabolism 0.512173913 0 0.778120978 kegg kegg NA NA no no no no no no Arginine biosynthesis Sulfur metabolism 0 0 0.526640927 kegg kegg NA NA no no no no no no beta-Alanine metabolism Sulfur metabolism 0.53826087 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Sulfur metabolism 0.563478261 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Sulfur metabolism 0 0.459486166 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Sulfur metabolism 0.471304348 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Sulfur metabolism 0.562608696 0.612648221 0.721750322 kegg kegg NA NA no no no no no no Glycerolipid metabolism Sulfur metabolism 0 0 -0.416216216 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Sulfur metabolism 0 0 -0.432689833 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Sulfur metabolism 0.530434783 0.609683794 0.755984556 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Sulfur metabolism 0.426956522 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Sulfur metabolism 0.592173913 0 -0.49009009 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Sulfur metabolism 0 0 -0.422908623 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Sulfur metabolism 0 0 0.449163449 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Sulfur metabolism 0 0 0.466666667 kegg kegg NA NA no no no no no no Lysine degradation Sulfur metabolism 0 0 -0.506563707 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Sulfur metabolism 0 0 -0.498584299 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Sulfur metabolism 0 0 -0.562162162 kegg kegg NA NA no no no no no no Nitrogen metabolism Sulfur metabolism 0 0 0.586357786 kegg kegg NA NA no no no no no no One carbon pool by folate Sulfur metabolism 0 0 -0.430630631 kegg kegg NA NA no no no no no no Other glycan degradation Sulfur metabolism 0 0 -0.441184041 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Sulfur metabolism 0 0 -0.465894466 kegg kegg NA NA no no no no no no Oxidative phosphorylation Sulfur metabolism -0.41826087 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Sulfur metabolism 0 0 -0.413899614 kegg kegg NA NA no no no no no no Pentose phosphate pathway Sulfur metabolism 0 0 0.540797941 kegg kegg NA NA no no no no no no Phenylalanine metabolism Sulfur metabolism 0.448695652 0 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Sulfur metabolism 0.565217391 0.644268775 0.782754183 kegg kegg NA NA no no no no no no Purine metabolism Sulfur metabolism 0.565217391 0.565217391 0.487001287 kegg kegg NA NA no no no no no no Pyrimidine metabolism Sulfur metabolism 0.416521739 0.553359684 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Sulfur metabolism 0 0.447628458 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Sulfur metabolism 0.440869565 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Sulfur metabolism 0 0.459486166 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Sulfur metabolism 0 0 -0.416988417 kegg kegg NA NA no no no no no no Thiamine metabolism Sulfur metabolism 0 0.541501976 0.416988417 kegg kegg NA NA no no no no no no Tryptophan metabolism Sulfur metabolism 0.487826087 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Sulfur metabolism 0 0.424901186 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Sulfur metabolism 0.440869565 0.415019763 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Sulfur metabolism 0.430434783 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Sulfur metabolism 0 0 -0.606692407 kegg kegg NA NA no no no no no no Bacteroides Sutterella 0.448266836 0 0 LPS-producing Genus Genus 0.000267 0.0582 dn dn up no no up 2-Oxocarboxylic acid metabolism Synaptic vesicle cycle 0 -0.549407115 0 kegg kegg NA NA no no no no up up Adrenergic signaling in cardiomyocytes Synaptic vesicle cycle 0 -0.700592885 -0.686486486 kegg kegg NA NA no no up no up up "Alanine, aspartate and glutamate metabolism" Synaptic vesicle cycle 0 0.68083004 0.463063063 kegg kegg NA NA no no no no up up alpha-Linolenic acid metabolism Synaptic vesicle cycle 0 0.493083004 0.456885457 kegg kegg NA NA no no no no up up Amino sugar and nucleotide sugar metabolism Synaptic vesicle cycle 0 0 0.452509653 kegg kegg NA NA no no no no up up Aminoacyl-tRNA biosynthesis Synaptic vesicle cycle 0 -0.437747036 0 kegg kegg NA NA no no no no up up AMPK signaling pathway Synaptic vesicle cycle -0.486086957 -0.599802372 0 kegg kegg NA NA no no no no up up Antifolate resistance Synaptic vesicle cycle 0 -0.471343874 0 kegg kegg NA NA no no no no up up Apelin signaling pathway Synaptic vesicle cycle 0 -0.496047431 0 kegg kegg NA NA no no no no up up Apoptosis Synaptic vesicle cycle 0.419130435 0.565217391 0.532561133 kegg kegg NA NA no no no no up up Arginine and proline metabolism Synaptic vesicle cycle 0.566956522 0.665019763 0.531788932 kegg kegg NA NA no up no no up up Arginine biosynthesis Synaptic vesicle cycle 0.45826087 0.714426877 0.48957529 kegg kegg NA NA no no no no up up B cell receptor signaling pathway Synaptic vesicle cycle 0 0.435770751 0 kegg kegg NA NA no no no no up up Basal transcription factors Synaptic vesicle cycle 0 -0.589920949 0 kegg kegg NA NA no no no no up up Base excision repair Synaptic vesicle cycle -0.526086957 -0.595849802 0 kegg kegg NA NA no no no no up up Biosynthesis of amino acids Synaptic vesicle cycle 0 0.865612648 0.581981982 kegg kegg NA NA no no no no up up Biosynthesis of cofactors Synaptic vesicle cycle -0.437391304 -0.489130435 0 kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway Synaptic vesicle cycle 0 0.416996047 0 kegg kegg NA NA no no no no up up Calcium signaling pathway Synaptic vesicle cycle 0 -0.54743083 -0.625225225 kegg kegg NA NA no up up no up up Carbon metabolism Synaptic vesicle cycle 0 0.549407115 0.614671815 kegg kegg NA NA no no no no up up Cardiac muscle contraction Synaptic vesicle cycle 0 -0.56027668 0 kegg kegg NA NA no no up no up up Cell adhesion molecules Synaptic vesicle cycle 0 0.536561265 0 kegg kegg NA NA no no no no up up Cell cycle Synaptic vesicle cycle 0 -0.753952569 -0.618275418 kegg kegg NA NA no no no no up up Cellular senescence Synaptic vesicle cycle 0 0.444664032 0 kegg kegg NA NA no no no no up up cGMP-PKG signaling pathway Synaptic vesicle cycle 0.7 0.886363636 0.415186615 kegg kegg NA NA no no no no up up Chemokine signaling pathway Synaptic vesicle cycle 0 0.632411067 0 kegg kegg NA NA no no no no up up Circadian rhythm Synaptic vesicle cycle 0 -0.807312253 -0.505534106 kegg kegg NA NA no no no no up up Complement and coagulation cascades Synaptic vesicle cycle 0 0.853754941 0 kegg kegg NA NA no no no no up up Cysteine and methionine metabolism Synaptic vesicle cycle 0 0 -0.446589447 kegg kegg NA NA no no no no up up Cytokine-cytokine receptor interaction Synaptic vesicle cycle 0 0.665019763 0 kegg kegg NA NA no no no no up up DNA replication Synaptic vesicle cycle 0 -0.583992095 0 kegg kegg NA NA no no no no up up Drug metabolism - other enzymes Synaptic vesicle cycle 0 0 0.46048906 kegg kegg NA NA no no no no up up ECM-receptor interaction Synaptic vesicle cycle -0.834782609 0 -0.567310167 kegg kegg NA NA no up up no up up EGFR tyrosine kinase inhibitor resistance Synaptic vesicle cycle 0 -0.483201581 0 kegg kegg NA NA no no no no up up Endocrine resistance Synaptic vesicle cycle 0 -0.455533597 -0.47953668 kegg kegg NA NA no no no no up up Endocytosis Synaptic vesicle cycle 0 0.575098814 0 kegg kegg NA NA no no no no up up Ether lipid metabolism Synaptic vesicle cycle 0 -0.600790514 0 kegg kegg NA NA no no no no up up Fanconi anemia pathway Synaptic vesicle cycle 0 -0.519762846 0 kegg kegg NA NA no no no no up up Fatty acid biosynthesis Synaptic vesicle cycle 0.474782609 0.73715415 0.488030888 kegg kegg NA NA no no no no up up Fatty acid degradation Synaptic vesicle cycle 0 0.574110672 0.52998713 kegg kegg NA NA no no no no up up Fatty acid metabolism Synaptic vesicle cycle 0 0.683794466 0.454826255 kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway Synaptic vesicle cycle 0.426956522 0.648221344 0.552123552 kegg kegg NA NA no no no no up up Fc gamma R-mediated phagocytosis Synaptic vesicle cycle 0.554782609 0.89229249 0.499099099 kegg kegg NA NA no no no no up up Folate biosynthesis Synaptic vesicle cycle 0 -0.584980237 0 kegg kegg NA NA no no no no up up Fructose and mannose metabolism Synaptic vesicle cycle 0 0 0.668468468 kegg kegg NA NA no no no no up up Galactose metabolism Synaptic vesicle cycle 0 0.466403162 0.481081081 kegg kegg NA NA no no no no up up Glutathione metabolism Synaptic vesicle cycle 0 -0.447628458 0 kegg kegg NA NA no no no no up up "Glycine, serine and threonine metabolism" Synaptic vesicle cycle -0.50173913 0 0 kegg kegg NA NA no up no no up up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Synaptic vesicle cycle 0.553913043 0 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Synaptic vesicle cycle 0 -0.503952569 0 kegg kegg NA NA no no no no up up Glycosaminoglycan biosynthesis - keratan sulfate Synaptic vesicle cycle 0 -0.610671937 -0.427027027 kegg kegg NA NA no no no no up up Glycosaminoglycan degradation Synaptic vesicle cycle 0.570434783 0.587944664 0.458687259 kegg kegg NA NA no no up no up up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Synaptic vesicle cycle 0 -0.491106719 0 kegg kegg NA NA no no no no up up Glyoxylate and dicarboxylate metabolism Synaptic vesicle cycle 0 0.732213439 0.569369369 kegg kegg NA NA no no no no up up Hedgehog signaling pathway Synaptic vesicle cycle 0 -0.609683794 0 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Synaptic vesicle cycle 0.547826087 0.432806324 0.498326898 kegg kegg NA NA no no no no up up Histidine metabolism Synaptic vesicle cycle 0 0 0.496267696 kegg kegg NA NA no no no no up up Homologous recombination Synaptic vesicle cycle 0 0 -0.427027027 kegg kegg NA NA no no no no up up IL-17 signaling pathway Synaptic vesicle cycle 0.605217391 0.871541502 0.679279279 kegg kegg NA NA no no no no up up Lysine degradation Synaptic vesicle cycle -0.424347826 -0.710474308 0 kegg kegg NA NA no no no no up up Lysosome Synaptic vesicle cycle 0.679130435 0.82312253 0.837580438 kegg kegg NA NA no no no no up up Mannose type O-glycan biosynthesis Synaptic vesicle cycle 0 -0.703557312 0 kegg kegg NA NA no no no no up up Mitophagy - animal Synaptic vesicle cycle 0 -0.479249012 0 kegg kegg NA NA no no no no up up mRNA surveillance pathway Synaptic vesicle cycle 0 -0.907114625 -0.532046332 kegg kegg NA NA no no no no up up mTOR signaling pathway Synaptic vesicle cycle 0 -0.490118577 0 kegg kegg NA NA no no no no up up N-Glycan biosynthesis Synaptic vesicle cycle -0.533913043 -0.721343874 -0.547490347 kegg kegg NA NA no no no no up up Natural killer cell mediated cytotoxicity Synaptic vesicle cycle 0 0.527667984 0 kegg kegg NA NA no no no no up up Neuroactive ligand-receptor interaction Synaptic vesicle cycle 0.526956522 0.798418972 0.698326898 kegg kegg NA NA up up up no up up Neutrophil extracellular trap formation Synaptic vesicle cycle 0.589565217 0.904150198 0.601544402 kegg kegg NA NA no no no no up up Nicotinate and nicotinamide metabolism Synaptic vesicle cycle 0.657391304 0.776679842 0.661776062 kegg kegg NA NA no no no no up up Nitrogen metabolism Synaptic vesicle cycle 0.417391304 0.643280632 0 kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Synaptic vesicle cycle 0.563478261 0.490118577 0 kegg kegg NA NA no no no no up up Notch signaling pathway Synaptic vesicle cycle 0.462608696 0 0 kegg kegg NA NA no no no no up up Nucleotide excision repair Synaptic vesicle cycle 0 -0.51284585 0 kegg kegg NA NA no no no no up up One carbon pool by folate Synaptic vesicle cycle 0 -0.524703557 0 kegg kegg NA NA no no no no up up Oocyte meiosis Synaptic vesicle cycle 0 0 -0.577348777 kegg kegg NA NA no no no no up up Osteoclast differentiation Synaptic vesicle cycle 0.673913043 0.744071146 0.582754183 kegg kegg NA NA no no no no up up Other types of O-glycan biosynthesis Synaptic vesicle cycle 0 -0.669960474 0 kegg kegg NA NA no no no no up up Oxidative phosphorylation Synaptic vesicle cycle 0 -0.52173913 0 kegg kegg NA NA no no no no up up Pantothenate and CoA biosynthesis Synaptic vesicle cycle 0.617391304 0.781620553 0.717117117 kegg kegg NA NA no no dn no up up Pentose and glucuronate interconversions Synaptic vesicle cycle 0 -0.588932806 0 kegg kegg NA NA no no no no up up Pentose phosphate pathway Synaptic vesicle cycle 0 0.931818182 0.793564994 kegg kegg NA NA no no no no up up Peroxisome Synaptic vesicle cycle 0.463478261 0.751976285 0.44993565 kegg kegg NA NA no no no no up up Phagosome Synaptic vesicle cycle 0 0.722332016 0 kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system Synaptic vesicle cycle 0 -0.443675889 0 kegg kegg NA NA no no no no up up Porphyrin and chlorophyll metabolism Synaptic vesicle cycle -0.445217391 0 0 kegg kegg NA NA no no no no up up PPAR signaling pathway Synaptic vesicle cycle 0 0.622529644 0 kegg kegg NA NA no no no no up up Proteasome Synaptic vesicle cycle 0 0 0.456370656 kegg kegg NA NA no no no no up up Protein export Synaptic vesicle cycle 0 -0.586956522 0 kegg kegg NA NA no no no no up up Protein processing in endoplasmic reticulum Synaptic vesicle cycle -0.607826087 -0.795454545 0 kegg kegg NA NA no no no no up up Purine metabolism Synaptic vesicle cycle -0.432173913 -0.497035573 0 kegg kegg NA NA no no no no up up Pyrimidine metabolism Synaptic vesicle cycle 0 -0.454545455 0 kegg kegg NA NA no no no no up up Pyruvate metabolism Synaptic vesicle cycle 0 -0.42687747 0 kegg kegg NA NA no no no no up up Ras signaling pathway Synaptic vesicle cycle 0 -0.491106719 0 yes kegg kegg NA NA no up up no up up Renin-angiotensin system Synaptic vesicle cycle 0.534782609 0.78458498 0.541570142 kegg kegg NA NA no no no no up up Ribosome Synaptic vesicle cycle 0 -0.477272727 0 kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes Synaptic vesicle cycle -0.550434783 -0.687747036 -0.447619048 kegg kegg NA NA no no no no up up RNA degradation Synaptic vesicle cycle 0 -0.843873518 -0.445559846 kegg kegg NA NA no no no no up up RNA polymerase Synaptic vesicle cycle -0.506086957 -0.785573123 0 kegg kegg NA NA no no no no up up RNA transport Synaptic vesicle cycle -0.445217391 -0.444664032 -0.538738739 kegg kegg NA NA no no no no up up Signaling pathways regulating pluripotency of stem cells Synaptic vesicle cycle 0 -0.552371542 -0.437837838 kegg kegg NA NA no no no no up up Sphingolipid metabolism Synaptic vesicle cycle 0.547826087 0 0.514800515 kegg kegg NA NA no no no no up up Spliceosome Synaptic vesicle cycle -0.482608696 -0.553359684 -0.581981982 kegg kegg NA NA no no no no up up Starch and sucrose metabolism Synaptic vesicle cycle 0.505217391 0.712450593 0.833462033 kegg kegg NA NA no no no no up up T cell receptor signaling pathway Synaptic vesicle cycle 0 0 -0.487001287 kegg kegg NA NA no no no no up up TGF-beta signaling pathway Synaptic vesicle cycle 0 -0.473320158 0 kegg kegg NA NA no no no no up up Thermogenesis Synaptic vesicle cycle 0 -0.56027668 0 kegg kegg NA NA no no no no up up Tight junction Synaptic vesicle cycle 0 0 0.405662806 kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway Synaptic vesicle cycle 0 0.549407115 0 yes kegg kegg NA NA no no no no up up Ubiquitin mediated proteolysis Synaptic vesicle cycle 0 -0.590909091 0 kegg kegg NA NA no no no no up up Various types of N-glycan biosynthesis Synaptic vesicle cycle -0.457391304 -0.659090909 -0.423423423 kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor Synaptic vesicle cycle 0 0.636363636 0 kegg kegg NA NA no no no no up up Wnt signaling pathway Synaptic vesicle cycle 0 -0.804347826 0 kegg kegg NA NA no no no no up up Methanobrevibacter Synergistes 0 0.512286901 0 Genus Genus 0.629 0.0843 no no no no no no Methanosphaera Synergistes 0 0.469999263 0 Genus Genus 0.0703 0.0843 no no no no no no Ascorbate and aldarate metabolism Synthesis and degradation of ketone bodies 0.51826087 0 0.593307593 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Synthesis and degradation of ketone bodies 0.8 0.785573123 0.711969112 kegg kegg NA NA no no no no no no Fatty acid degradation Synthesis and degradation of ketone bodies 0 0 0.433204633 kegg kegg NA NA no no no no no no Fatty acid elongation Synthesis and degradation of ketone bodies 0.542608696 0.424901186 0.556241956 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Synthesis and degradation of ketone bodies 0.503478261 0.444664032 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Synthesis and degradation of ketone bodies 0.672173913 0.719367589 0.463835264 kegg kegg NA NA no no no no no no Pentose phosphate pathway Synthesis and degradation of ketone bodies 0 -0.503952569 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Systemic lupus erythematosus -0.56173913 -0.566205534 -0.432689833 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Systemic lupus erythematosus 0 0.489130435 0 kegg kegg NA NA no no no no no no Akkermansia Systemic lupus erythematosus 0.426994086 0 0 acetate-producing Genus kegg 0.23 NA no no no no no no "Alanine, aspartate and glutamate metabolism" Systemic lupus erythematosus 0.439130435 0 0 kegg kegg NA NA no no no no no no Alcoholism Systemic lupus erythematosus 0 0.463438735 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Systemic lupus erythematosus -0.546956522 -0.701581028 0 kegg kegg NA NA no up up no no no Alzheimer disease Systemic lupus erythematosus -0.494782609 -0.455533597 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Systemic lupus erythematosus 0 -0.508893281 0 kegg kegg NA NA no no no no no no Amoebiasis Systemic lupus erythematosus 0 0.4743083 0.497039897 kegg kegg NA NA no no no no no no Amphetamine addiction Systemic lupus erythematosus -0.650434783 -0.726284585 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Systemic lupus erythematosus 0 -0.75 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Systemic lupus erythematosus -0.513043478 -0.533596838 0 kegg kegg NA NA no no no no no no Antifolate resistance Systemic lupus erythematosus 0 -0.548418972 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Systemic lupus erythematosus 0.446956522 0.524703557 0.615186615 kegg kegg NA NA no no no no no no Apelin signaling pathway Systemic lupus erythematosus -0.443478261 0 0 kegg kegg NA NA no no no no no no Apoptosis Systemic lupus erythematosus 0 0.610671937 0.50965251 kegg kegg NA NA no no no no no no Arginine and proline metabolism Systemic lupus erythematosus 0 0.555335968 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Systemic lupus erythematosus 0.48173913 0.423913043 0.466409266 kegg kegg NA NA no no no no no no Asthma Systemic lupus erythematosus 0 0 0.597425997 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Systemic lupus erythematosus 0.405217391 0.687747036 0 kegg kegg NA NA no no no no no no Autophagy - other Systemic lupus erythematosus 0 0 -0.506306306 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Systemic lupus erythematosus 0 0.472332016 0 kegg kegg NA NA no no no no no no Bacteroides Systemic lupus erythematosus 0.422608696 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal cell carcinoma Systemic lupus erythematosus -0.506086957 -0.659090909 -0.725096525 kegg kegg NA NA no no no no no no Basal transcription factors Systemic lupus erythematosus 0 -0.663043478 -0.555727156 kegg kegg NA NA no no no no no no Base excision repair Systemic lupus erythematosus 0 -0.611660079 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Systemic lupus erythematosus 0.44173913 0 0 kegg kegg NA NA no no no no no no Bile secretion Systemic lupus erythematosus -0.543478261 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Systemic lupus erythematosus 0.519130435 0.747035573 0.698326898 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Systemic lupus erythematosus 0 -0.625494071 0 kegg kegg NA NA no no no no no no Bladder cancer Systemic lupus erythematosus 0.46173913 0.500988142 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Systemic lupus erythematosus 0 0.470355731 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Systemic lupus erythematosus 0 -0.447628458 -0.417245817 kegg kegg NA NA no up up no no no cAMP signaling pathway Systemic lupus erythematosus -0.543478261 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Systemic lupus erythematosus 0.411304348 0.597826087 0.652252252 kegg kegg NA NA no no no no no no Cardiac muscle contraction Systemic lupus erythematosus -0.44 -0.459486166 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Systemic lupus erythematosus 0.408695652 0.722332016 0.410810811 kegg kegg NA NA no no no no no no Cell cycle Systemic lupus erythematosus 0 -0.769762846 -0.541312741 kegg kegg NA NA no no no no no no Cellular senescence Systemic lupus erythematosus 0 0.608695652 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Systemic lupus erythematosus 0 0.81916996 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Systemic lupus erythematosus 0 0.500988142 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Systemic lupus erythematosus -0.694782609 -0.691699605 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Systemic lupus erythematosus 0 0.589920949 0 kegg kegg NA NA no no no no no no Cholesterol metabolism Systemic lupus erythematosus 0 0.618577075 0 yes kegg kegg NA NA no no up no no no Choline metabolism in cancer Systemic lupus erythematosus 0 0 -0.457657658 kegg kegg NA NA no no no no no no Circadian entrainment Systemic lupus erythematosus -0.466086957 0 0 kegg kegg NA NA no up up no no no Circadian rhythm Systemic lupus erythematosus 0 -0.790513834 -0.666151866 kegg kegg NA NA no no no no no no Clostridium Systemic lupus erythematosus 0 0.438086354 0 Genus kegg 0.925 NA no no no no no no Cocaine addiction Systemic lupus erythematosus -0.55826087 -0.626482213 0 kegg kegg NA NA no no no no no no Colorectal cancer Systemic lupus erythematosus -0.406956522 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Systemic lupus erythematosus 0.428695652 0.824110672 0.693178893 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Systemic lupus erythematosus -0.637391304 0 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Systemic lupus erythematosus -0.630434783 -0.70256917 0 kegg kegg NA NA no no up no no no Cushing syndrome Systemic lupus erythematosus -0.669565217 -0.815217391 -0.456628057 kegg kegg NA NA no no up no no no Cytokine-cytokine receptor interaction Systemic lupus erythematosus 0 0.449604743 0 kegg kegg NA NA no no no no no no DNA replication Systemic lupus erythematosus 0 -0.529644269 -0.466151866 kegg kegg NA NA no no no no no no Dopaminergic synapse Systemic lupus erythematosus -0.613913043 0 0 kegg kegg NA NA no up no no no no EGFR tyrosine kinase inhibitor resistance Systemic lupus erythematosus -0.420869565 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Systemic lupus erythematosus -0.455652174 -0.600790514 0 kegg kegg NA NA no no no no no no Endocrine resistance Systemic lupus erythematosus -0.566086957 -0.602766798 0 kegg kegg NA NA no no no no no no Endocytosis Systemic lupus erythematosus 0 0.738142292 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Systemic lupus erythematosus 0 0.65513834 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Systemic lupus erythematosus 0 0.5256917 0.415958816 kegg kegg NA NA no no no no no no Estrogen signaling pathway Systemic lupus erythematosus 0 -0.455533597 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Systemic lupus erythematosus -0.419130435 -0.577075099 -0.433976834 kegg kegg NA NA no no no no no no Fanconi anemia pathway Systemic lupus erythematosus 0 -0.665019763 -0.458687259 kegg kegg NA NA no no no no no no Fat digestion and absorption Systemic lupus erythematosus 0 0.663043478 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Systemic lupus erythematosus 0.41826087 0.459486166 0 kegg kegg NA NA no no no no no no Fatty acid degradation Systemic lupus erythematosus 0.48 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Systemic lupus erythematosus 0.588695652 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Systemic lupus erythematosus 0.665217391 0.505928854 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Systemic lupus erythematosus 0 0.601778656 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Systemic lupus erythematosus 0.623478261 0.871541502 0.723294723 kegg kegg NA NA no no no no no no GABAergic synapse Systemic lupus erythematosus 0.447826087 0.423913043 0.406177606 kegg kegg NA NA no up up no no no Galactose metabolism Systemic lupus erythematosus 0.46 0 0 kegg kegg NA NA no no no no no no Gastric cancer Systemic lupus erythematosus 0 -0.472332016 -0.512741313 kegg kegg NA NA no no no no no no Glucagon signaling pathway Systemic lupus erythematosus -0.631304348 -0.768774704 -0.518918919 kegg kegg NA NA no no no no no no Glutathione metabolism Systemic lupus erythematosus 0 -0.504940711 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Systemic lupus erythematosus 0 0 -0.542599743 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Systemic lupus erythematosus 0 0 -0.576319176 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Systemic lupus erythematosus 0 -0.599802372 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Systemic lupus erythematosus 0 0 0.452509653 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Systemic lupus erythematosus 0 0 -0.495238095 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Systemic lupus erythematosus 0 0.668972332 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Systemic lupus erythematosus 0 -0.451581028 -0.465637066 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Systemic lupus erythematosus 0 0 -0.497812098 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Systemic lupus erythematosus 0 -0.634387352 -0.528185328 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Systemic lupus erythematosus 0.636521739 0.475296443 0.470527671 kegg kegg NA NA no no no no no no GnRH signaling pathway Systemic lupus erythematosus -0.422608696 -0.588932806 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Systemic lupus erythematosus -0.429565217 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Systemic lupus erythematosus 0 -0.691699605 -0.571685972 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Systemic lupus erythematosus 0 0 0.417245817 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Systemic lupus erythematosus 0 0.491106719 0.440669241 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Systemic lupus erythematosus 0.436521739 0.428853755 0 kegg kegg NA NA no no no no no no Homologous recombination Systemic lupus erythematosus 0 -0.542490119 0 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Systemic lupus erythematosus 0 0.544466403 0.405920206 kegg kegg NA NA no no dn no no no Human immunodeficiency virus 1 infection Systemic lupus erythematosus 0 0.517786561 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Systemic lupus erythematosus 0 0.531620553 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Systemic lupus erythematosus 0 0.480237154 0.518661519 kegg kegg NA NA no no no no no no Huntington disease Systemic lupus erythematosus -0.444347826 -0.48715415 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Systemic lupus erythematosus 0 0.799407115 0.48005148 kegg kegg NA NA no no no no no no Inflammatory bowel disease Systemic lupus erythematosus 0.462608696 0.568181818 0.558815959 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Systemic lupus erythematosus -0.535652174 -0.527667984 0 kegg kegg NA NA no no no no no no Influenza A Systemic lupus erythematosus 0.446086957 0.671936759 0.485199485 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Systemic lupus erythematosus 0 0 -0.498326898 kegg kegg NA NA no no no no no no Insulin resistance Systemic lupus erythematosus 0 0 -0.416216216 kegg kegg NA NA no no no no no no Insulin secretion Systemic lupus erythematosus -0.533913043 -0.688735178 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Systemic lupus erythematosus -0.425217391 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Systemic lupus erythematosus 0 0 0.511454311 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection Systemic lupus erythematosus -0.462608696 0 0 kegg kegg NA NA no no dn no no no Leishmaniasis Systemic lupus erythematosus 0.413913043 0 0.578378378 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Systemic lupus erythematosus 0 0.513833992 0.506563707 kegg kegg NA NA no no no no no no Long-term depression Systemic lupus erythematosus -0.428695652 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Systemic lupus erythematosus 0 -0.415019763 0 kegg kegg NA NA no no no no no no Lysine degradation Systemic lupus erythematosus 0 -0.666007905 -0.614929215 kegg kegg NA NA no no no no no no Lysosome Systemic lupus erythematosus 0.511304348 0.913043478 0.522007722 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Systemic lupus erythematosus 0 -0.563241107 -0.657915058 kegg kegg NA NA no no no no no no Melanogenesis Systemic lupus erythematosus -0.562608696 -0.537549407 0 kegg kegg NA NA no no no no no no Mineral absorption Systemic lupus erythematosus -0.512173913 -0.428853755 0 kegg kegg NA NA no no no no no no Mitophagy - animal Systemic lupus erythematosus -0.644347826 -0.585968379 0 kegg kegg NA NA no no no no no no Morphine addiction Systemic lupus erythematosus -0.473043478 -0.466403162 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Systemic lupus erythematosus -0.424347826 -0.717391304 -0.714543115 kegg kegg NA NA no no no no no no mTOR signaling pathway Systemic lupus erythematosus -0.447826087 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Systemic lupus erythematosus 0 -0.581027668 -0.477734878 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Systemic lupus erythematosus 0 0.668972332 0 kegg kegg NA NA no no no no no no Necroptosis Systemic lupus erythematosus -0.507826087 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Systemic lupus erythematosus 0 0.911067194 0.600514801 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Systemic lupus erythematosus 0.59826087 0.893280632 0.757014157 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Systemic lupus erythematosus 0.486086957 0.572134387 0 kegg kegg NA NA no no no no no no Nicotine addiction Systemic lupus erythematosus 0 -0.513833992 0 kegg kegg NA NA no up up no no no Nitrogen metabolism Systemic lupus erythematosus 0 0.422924901 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Systemic lupus erythematosus 0.463478261 0.489130435 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Systemic lupus erythematosus -0.533913043 -0.446640316 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Systemic lupus erythematosus 0 0 -0.494723295 kegg kegg NA NA no no no no no no Notch signaling pathway Systemic lupus erythematosus 0 0 -0.547232947 kegg kegg NA NA no no no no no no Nucleotide excision repair Systemic lupus erythematosus 0 -0.563241107 0 kegg kegg NA NA no no no no no no Olfactory transduction Systemic lupus erythematosus 0 0.765810277 0.470527671 kegg kegg NA NA no no no no no no One carbon pool by folate Systemic lupus erythematosus 0 -0.570158103 -0.491891892 kegg kegg NA NA no no no no no no Osteoclast differentiation Systemic lupus erythematosus 0.48173913 0.716403162 0.497554698 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Systemic lupus erythematosus 0 -0.690711462 -0.59047619 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Systemic lupus erythematosus -0.509565217 0 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Systemic lupus erythematosus -0.450434783 -0.429841897 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Systemic lupus erythematosus 0 0 0.486743887 kegg kegg NA NA no no no no no no p53 signaling pathway Systemic lupus erythematosus 0 -0.510869565 -0.488030888 kegg kegg NA NA no no no no no no Pancreatic secretion Systemic lupus erythematosus -0.48 0 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Systemic lupus erythematosus 0.422608696 0.648221344 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Systemic lupus erythematosus -0.690434783 -0.494071146 0 kegg kegg NA NA no no no no no no Parkinson disease Systemic lupus erythematosus -0.600869565 -0.485177866 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Systemic lupus erythematosus 0 0.760869565 0.565765766 kegg kegg NA NA no no no no no no Pathways in cancer Systemic lupus erythematosus 0 0 -0.402574003 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Systemic lupus erythematosus -0.597391304 -0.527667984 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Systemic lupus erythematosus 0 -0.416007905 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Systemic lupus erythematosus 0.432173913 0.886363636 0.619047619 kegg kegg NA NA no no no no no no Peroxisome Systemic lupus erythematosus 0.592173913 0.542490119 0.436550837 kegg kegg NA NA no no no no no no Pertussis Systemic lupus erythematosus 0.54173913 0.841897233 0.74028314 kegg kegg NA NA no no dn no no no Phagosome Systemic lupus erythematosus 0.506086957 0.841897233 0.592535393 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Systemic lupus erythematosus 0 -0.446640316 -0.642471042 kegg kegg NA NA no no no no no no Platinum drug resistance Systemic lupus erythematosus 0 -0.441699605 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Systemic lupus erythematosus 0 -0.603754941 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Systemic lupus erythematosus 0 0.533596838 0.417245817 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Systemic lupus erythematosus 0 0 0.462805663 kegg kegg NA NA no no no no no no Prion disease Systemic lupus erythematosus -0.485217391 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Systemic lupus erythematosus 0 -0.499011858 -0.45997426 kegg kegg NA NA no no no no no no Protein digestion and absorption Systemic lupus erythematosus 0.523478261 0.54743083 0 yes kegg kegg NA NA no up up no no no Protein export Systemic lupus erythematosus 0 0 -0.439124839 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Systemic lupus erythematosus -0.405217391 -0.696640316 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Systemic lupus erythematosus -0.41826087 0 0 kegg kegg NA NA no no no no no no Purine metabolism Systemic lupus erythematosus 0 -0.757905138 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Systemic lupus erythematosus 0.426956522 -0.416007905 0 kegg kegg NA NA no no no no no no Ras signaling pathway Systemic lupus erythematosus 0 0 -0.444015444 yes kegg kegg NA NA no up up no no no Regulation of lipolysis in adipocytes Systemic lupus erythematosus -0.593043478 -0.415019763 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Systemic lupus erythematosus -0.520869565 0 0 kegg kegg NA NA no no no no no no Renin secretion Systemic lupus erythematosus -0.484347826 -0.418972332 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Systemic lupus erythematosus 0.555652174 0.90513834 0 kegg kegg NA NA no no no no no no Ribosome Systemic lupus erythematosus -0.624347826 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Systemic lupus erythematosus 0 -0.747035573 -0.584555985 kegg kegg NA NA no no no no no no RNA degradation Systemic lupus erythematosus 0 -0.60770751 -0.557786358 kegg kegg NA NA no no no no no no RNA polymerase Systemic lupus erythematosus 0 -0.788537549 -0.481081081 kegg kegg NA NA no no no no no no Ruminococcus Systemic lupus erythematosus -0.427826087 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Salmonella infection Systemic lupus erythematosus 0 0.694664032 0.595366795 kegg kegg NA NA no no no no no no Selenocompound metabolism Systemic lupus erythematosus 0 -0.562252964 -0.464607465 kegg kegg NA NA no no no no no no Shigellosis Systemic lupus erythematosus -0.531304348 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Systemic lupus erythematosus -0.445217391 -0.490118577 -0.549034749 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Systemic lupus erythematosus 0 0.590909091 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Systemic lupus erythematosus 0 -0.658102767 -0.489317889 kegg kegg NA NA no no no no no no Spliceosome Systemic lupus erythematosus 0 -0.562252964 -0.461776062 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Systemic lupus erythematosus 0.872173913 0.958498024 0.925096525 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Systemic lupus erythematosus 0 0.516798419 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Systemic lupus erythematosus 0 0.763833992 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Systemic lupus erythematosus 0 -0.458498024 0 kegg kegg NA NA no no no no no no Taste transduction Systemic lupus erythematosus 0 -0.59486166 -0.583526384 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Systemic lupus erythematosus 0 0 -0.566537967 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Systemic lupus erythematosus 0 0 -0.465894466 kegg kegg NA NA no no no no no no Thermogenesis Systemic lupus erythematosus -0.524347826 -0.459486166 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Systemic lupus erythematosus -0.446086957 -0.593873518 0 kegg kegg NA NA no no no no no no Tight junction Systemic lupus erythematosus 0 0 0.512998713 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Systemic lupus erythematosus 0 0.523715415 0 yes kegg kegg NA NA no no no no no no Toxoplasmosis Systemic lupus erythematosus 0.429565217 0.57312253 0.559330759 kegg kegg NA NA no no no no no no Tuberculosis Systemic lupus erythematosus 0.876521739 0.947628458 0.835263835 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Systemic lupus erythematosus 0.405217391 0.68083004 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Systemic lupus erythematosus 0 0 -0.429086229 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Systemic lupus erythematosus -0.643478261 -0.688735178 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Systemic lupus erythematosus 0 -0.443675889 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Systemic lupus erythematosus -0.515652174 0 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Systemic lupus erythematosus -0.573913043 -0.485177866 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Systemic lupus erythematosus 0 0.611660079 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Systemic lupus erythematosus 0 0.520750988 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Systemic lupus erythematosus 0 -0.62944664 -0.584555985 kegg kegg NA NA no no no no no no Yersinia infection Systemic lupus erythematosus 0 0.801383399 0 kegg kegg NA NA no no no no no no 16:0/22:6-PC+blood Systolic_Pressure+clinic 0 0.610714286 0 serum_phospholipids clinic 4.53E-05 0.00205 no up up up up no 16:1/18:2-PG+blood Systolic_Pressure+clinic 0 -0.667857143 0 serum_phospholipids clinic 1.40E-08 0.00205 no up up up up no 18:0-LPA+blood Systolic_Pressure+clinic 0 0 -0.405384615 serum_phospholipids clinic 0.0725 0.00205 no dn no up up no 18:0-LPC+blood Systolic_Pressure+clinic -0.574819401 0 0 serum_phospholipids clinic 0.554 0.00205 no no no up up no 18:0-LPE+blood Systolic_Pressure+clinic -0.55624355 0 0.508461538 serum_phospholipids clinic 0.491 0.00205 no no no up up no 18:0/20:3-PC+blood Systolic_Pressure+clinic -0.574819401 0 0 serum_phospholipids clinic 0.0682 0.00205 no up no up up no 18:0/20:4-PC+blood Systolic_Pressure+clinic 0 0.7 0 serum_phospholipids clinic 0.454 0.00205 no no no up up no 18:0/20:5-PC+blood Systolic_Pressure+clinic 0 0.646428571 0 serum_phospholipids clinic 0.17 0.00205 no no no up up no 18:0+blood Systolic_Pressure+clinic -0.50877193 0 0 serum_fattyacid clinic 0.344 0.00205 no no no up up no 18:1/18:1-PE+blood Systolic_Pressure+clinic 0 -0.525 0 serum_phospholipids clinic 1.03E-05 0.00205 up up no up up no 18:1/20:4-PC+blood Systolic_Pressure+clinic 0 0.589285714 0 serum_phospholipids clinic 0.582 0.00205 no no no up up no 20:2/18:0-PC+blood Systolic_Pressure+clinic -0.51496388 0 0 serum_phospholipids clinic 0.0427 0.00205 no up no up up no 20:3n6+blood Systolic_Pressure+clinic -0.630546956 -0.564285714 0 serum_fattyacid clinic 0.0884 0.00205 up no no up up no 20:5/18:0-PC+blood Systolic_Pressure+clinic 0 0.564285714 0 serum_phospholipids clinic 3.97E-06 0.00205 no up up up up no 22:6n3+blood Systolic_Pressure+clinic -0.543859649 0 -0.425384615 serum_fattyacid clinic 0.792 0.00205 no no no up up no 4-hydroxybenzoic acid+urine Systolic_Pressure+clinic 0 0.600490196 0 urine_cometabolism clinic 0.52 0.00205 no no no up up no 9-HODE+blood Systolic_Pressure+clinic 0 0 0.696153846 serum_ARA clinic 0.297 0.00205 no no no up up no Acetic acid+stool Systolic_Pressure+clinic 0 0.645454545 0 yes stool_scfa clinic 0.0656 0.00205 dn no no up up no Apoptosis Systolic_Pressure+clinic 0.523433089 0 0 kegg clinic NA 0.00205 no no no up up no Biosynthesis of amino acids Systolic_Pressure+clinic 0 0 -0.400560224 kegg clinic NA 0.00205 no no no up up no C-peptide Systolic_Pressure+clinic 0 -0.613777527 -0.402291826 DM-assocaited hormones clinic 0.228 0.00205 no no no up up no CA+blood Systolic_Pressure+clinic 0.475993868 0 0 serum_bileacids clinic 0.606 0.00205 no no no up up no Carbon metabolism Systolic_Pressure+clinic 0 0 -0.462464986 kegg clinic NA 0.00205 no no no up up no Creatinine+blood Systolic_Pressure+clinic 0 -0.564285714 -0.443076923 serum_choline clinic 0.437 0.00205 no no no up up no Cytosolic DNA-sensing pathway Systolic_Pressure+clinic 0.647656691 0 0 kegg clinic NA 0.00205 no no no up up no d18:1-16:1-SM+blood Systolic_Pressure+clinic 0 0 0.423076923 serum_phospholipids clinic 0.2 0.00205 no no no up up no d18:1-18:1-SM+blood Systolic_Pressure+clinic 0 0 0.408461538 serum_phospholipids clinic 0.916 0.00205 no no no up up no Eotaxin Systolic_Pressure+clinic 0 0 0.515270936 serum_cytokines clinic 0.393 0.00205 no no no up up no Glycolysis / Gluconeogenesis Systolic_Pressure+clinic 0 0 -0.403641457 kegg clinic NA 0.00205 no no no up up no Homovanillic acid+urine Systolic_Pressure+clinic -0.475748194 0 0 urine_cometabolism clinic 0.45 0.00205 no no no up up no L-Isoleucine+blood Systolic_Pressure+clinic 0 -0.564285714 -0.548461538 yes serum_aminoacids clinic 5.47E-06 0.00205 up up no up up no L-Leucine+blood Systolic_Pressure+clinic 0 -0.539285714 -0.420769231 yes serum_aminoacids clinic 3.22E-05 0.00205 up up no up up no L-Phenylalanine+blood Systolic_Pressure+clinic 0 -0.553571429 0 yes serum_aminoacids clinic 0.0103 0.00205 up up no up up no L-Proline+blood Systolic_Pressure+clinic 0 -0.739285714 0 yes serum_aminoacids clinic 0.00265 0.00205 up up no up up no L-Tryptophan+blood Systolic_Pressure+clinic 0 -0.696428571 0 serum_aminoacids clinic 0.164 0.00205 no no no up up no L-Tyrosine+blood Systolic_Pressure+clinic 0 -0.707142857 0 yes serum_aminoacids clinic 0.00913 0.00205 up up no up up no Leukocyte transendothelial migration Systolic_Pressure+clinic 0.429700734 0 0 kegg clinic NA 0.00205 no no no up up no MIP-1b Systolic_Pressure+clinic 0 0 0.555665025 serum_cytokines clinic 0.632 0.00205 no no no up up no n3+blood Systolic_Pressure+clinic 0 0 -0.436923077 serum_fattyacid clinic 0.806 0.00205 no no no up up no Non-small cell lung cancer Systolic_Pressure+clinic 0 0 0.415406162 kegg clinic NA 0.00205 no no no up up no P-hydroxyhippuric acid+urine Systolic_Pressure+clinic -0.496388029 0 0 urine_cometabolism clinic 0.436 0.00205 no no no up up no Parabacteroides Systolic_Pressure+clinic 0 0.483907397 0 Genus clinic 4.19E-05 0.00205 no up up up up no PUFA/MUFA+blood Systolic_Pressure+clinic 0.566563467 0 0 serum_fattyacid clinic 0.00108 0.00205 dn no up up up no RANTES Systolic_Pressure+clinic 0 0 0.522660099 yes serum_cytokines clinic 0.0757 0.00205 no no up up up no SFA%+blood Systolic_Pressure+clinic 0 0 -0.446923077 serum_fattyacid clinic 0.0236 0.00205 no up no up up no Systemic lupus erythematosus Systolic_Pressure+clinic 0 0 -0.434173669 kegg clinic NA 0.00205 no no no up up no TCA+blood Systolic_Pressure+clinic -0.48374236 0 0 serum_bileacids clinic 0.339 0.00205 no no no up up no TMAO+blood Systolic_Pressure+clinic 0 0 -0.405384615 serum_choline clinic 0.00706 0.00205 up up no up up no TXB2+blood Systolic_Pressure+clinic 0 0.746932502 0 yes serum_ARA clinic 0.0644 0.00205 dn no no up up no Valine+blood Systolic_Pressure+clinic 0 -0.567857143 -0.544615385 yes serum_aminoacids clinic 1.22E-06 0.00205 up up no up up no Visfatin Systolic_Pressure+clinic 0 0 0.500993125 DM-assocaited hormones clinic 0.0229 0.00205 dn no up up up no ABC transporters T cell receptor signaling pathway 0 0.549407115 0 kegg kegg NA NA no up up no no no Adherens junction T cell receptor signaling pathway 0 -0.748023715 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" T cell receptor signaling pathway 0 0.448616601 0 kegg kegg NA NA no no no no no no Alistipes T cell receptor signaling pathway 0 0.503716255 0 Genus kegg 0.0114 NA no up no no no no Amino sugar and nucleotide sugar metabolism T cell receptor signaling pathway 0 0 -0.44041184 kegg kegg NA NA no no no no no no Apoptosis - multiple species T cell receptor signaling pathway 0 0.501976285 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism T cell receptor signaling pathway -0.592173913 -0.462450593 -0.742084942 kegg kegg NA NA no no no no no no Autophagy - animal T cell receptor signaling pathway 0.513913043 0.684782609 0 kegg kegg NA NA no no no no no no Autophagy - other T cell receptor signaling pathway 0.613043478 0.753952569 0.727927928 kegg kegg NA NA no no no no no no Axon guidance T cell receptor signaling pathway 0 0 0.644530245 kegg kegg NA NA no up up no no no Basal transcription factors T cell receptor signaling pathway 0 0 0.463320463 kegg kegg NA NA no no no no no no Biosynthesis of cofactors T cell receptor signaling pathway 0 0 -0.414671815 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway T cell receptor signaling pathway 0.50173913 0.617588933 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction T cell receptor signaling pathway 0 -0.457509881 0 kegg kegg NA NA no no up no no no Cell cycle T cell receptor signaling pathway 0 0 0.468211068 kegg kegg NA NA no no no no no no Collinsella T cell receptor signaling pathway 0 0 -0.525641669 Genus kegg 0.128 NA no no no no no no Cytosolic DNA-sensing pathway T cell receptor signaling pathway 0 0.593873518 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 T cell receptor signaling pathway 0 -0.463438735 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes T cell receptor signaling pathway 0 -0.523715415 0 kegg kegg NA NA no no no no no no ErbB signaling pathway T cell receptor signaling pathway 0 0.563241107 0.558301158 kegg kegg NA NA no no no no no no Fatty acid degradation T cell receptor signaling pathway 0 0.433794466 0 kegg kegg NA NA no no no no no no Ferroptosis T cell receptor signaling pathway -0.445217391 0 0 kegg kegg NA NA no no no no no no Focal adhesion T cell receptor signaling pathway 0 -0.696640316 0 kegg kegg NA NA no up up no no no Folate biosynthesis T cell receptor signaling pathway 0.413913043 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway T cell receptor signaling pathway 0.431304348 0.591897233 0 kegg kegg NA NA no no no no no no Glutathione metabolism T cell receptor signaling pathway -0.535652174 -0.508893281 -0.590733591 kegg kegg NA NA no no no no no no Glycerolipid metabolism T cell receptor signaling pathway 0 0.507905138 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism T cell receptor signaling pathway 0 0.441699605 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" T cell receptor signaling pathway 0 0 -0.406949807 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate T cell receptor signaling pathway 0 0.511857708 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate T cell receptor signaling pathway 0 0 0.468725869 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series T cell receptor signaling pathway -0.479130435 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism T cell receptor signaling pathway 0 0.415019763 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage T cell receptor signaling pathway -0.522608696 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway T cell receptor signaling pathway 0 -0.644268775 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism T cell receptor signaling pathway 0 0.520750988 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway T cell receptor signaling pathway 0 0.630434783 0 kegg kegg NA NA no no no no no no Lachnospira T cell receptor signaling pathway 0 -0.570793198 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Lysine degradation T cell receptor signaling pathway 0.435652174 0.427865613 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis T cell receptor signaling pathway 0 0.424901186 0 kegg kegg NA NA no no no no no no MAPK signaling pathway T cell receptor signaling pathway 0.473043478 0.580039526 0.482625483 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 T cell receptor signaling pathway 0 -0.504940711 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway T cell receptor signaling pathway 0 0 0.444015444 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis T cell receptor signaling pathway 0 0.639328063 0.471814672 kegg kegg NA NA no no no no no no N-Glycan biosynthesis T cell receptor signaling pathway 0 0 0.524581725 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation T cell receptor signaling pathway 0 0 -0.423166023 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway T cell receptor signaling pathway 0.447826087 0.666007905 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway T cell receptor signaling pathway 0 0.619565217 0 kegg kegg NA NA no no no no no no Oocyte meiosis T cell receptor signaling pathway 0 0 0.497812098 kegg kegg NA NA no no no no no no Oscillospira T cell receptor signaling pathway 0 0.442687747 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation T cell receptor signaling pathway 0 0.428853755 0 kegg kegg NA NA no no no no no no Other glycan degradation T cell receptor signaling pathway 0 0.52173913 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation T cell receptor signaling pathway 0 -0.52173913 0 kegg kegg NA NA no no no no no no p53 signaling pathway T cell receptor signaling pathway 0 0.454545455 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway T cell receptor signaling pathway 0 0 -0.444530245 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway T cell receptor signaling pathway 0.716521739 0.416996047 0.432689833 yes kegg kegg NA NA no up up no no no Platelet activation T cell receptor signaling pathway 0 -0.833992095 0 kegg kegg NA NA no no no no no no Platinum drug resistance T cell receptor signaling pathway 0 0.503952569 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism T cell receptor signaling pathway 0 0 -0.401029601 kegg kegg NA NA no no no no no no PPAR signaling pathway T cell receptor signaling pathway 0 0.559288538 0 kegg kegg NA NA no no no no no no Purine metabolism T cell receptor signaling pathway -0.433913043 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism T cell receptor signaling pathway 0 -0.441699605 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway T cell receptor signaling pathway 0 -0.740118577 0 kegg kegg NA NA no no no no no no Ras signaling pathway T cell receptor signaling pathway 0 -0.416996047 0 yes kegg kegg NA NA no up up no no no Ribosome biogenesis in eukaryotes T cell receptor signaling pathway 0 0 0.450965251 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway T cell receptor signaling pathway 0.630434783 0.709486166 0 kegg kegg NA NA no no no no no no RNA degradation T cell receptor signaling pathway 0 0 0.498069498 kegg kegg NA NA no no no no no no RNA transport T cell receptor signaling pathway 0.546956522 0 0.463835264 kegg kegg NA NA no no no no no no Roseburia T cell receptor signaling pathway -0.471304348 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Signaling pathways regulating pluripotency of stem cells T cell receptor signaling pathway 0.474782609 0.444664032 0.611325611 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport T cell receptor signaling pathway 0 0.627470356 0 kegg kegg NA NA no no no no no no Spliceosome T cell receptor signaling pathway 0.565217391 0.602766798 0.602316602 kegg kegg NA NA no no no no no no Starch and sucrose metabolism T cell receptor signaling pathway 0 0 -0.473616474 kegg kegg NA NA no no no no no no Steroid biosynthesis T cell receptor signaling pathway 0 -0.422924901 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis T cell receptor signaling pathway 0 -0.490118577 0 kegg kegg NA NA no no no no no no Sulfur metabolism T cell receptor signaling pathway -0.485217391 0 -0.543114543 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism T cell receptor signaling pathway 0 0.461462451 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis T cell receptor signaling pathway 0 0 0.435263835 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation T cell receptor signaling pathway 0 0.504940711 0 kegg kegg NA NA no no no no no no Th17 cell differentiation T cell receptor signaling pathway 0 0.614624506 0 kegg kegg NA NA no no no no no no Tight junction T cell receptor signaling pathway 0 -0.693675889 -0.641441441 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway T cell receptor signaling pathway 0.446086957 0.524703557 0 yes kegg kegg NA NA no no no no no no Tyrosine metabolism T cell receptor signaling pathway 0 -0.503952569 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis T cell receptor signaling pathway 0.471304348 0 0.623680824 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction T cell receptor signaling pathway 0 -0.697628458 0 kegg kegg NA NA no no no no no no VEGF signaling pathway T cell receptor signaling pathway 0 0 0.457657658 kegg kegg NA NA no no no no no no 16:0/16:0-PC+blood T-a-MCA+blood 0 0 0.505728963 serum_phospholipids serum_bileacids 0.00079 0.478 no up up no no no 16:0/18:0-PC+blood T-a-MCA+blood 0 0 0.494641117 serum_phospholipids serum_bileacids 0.521 0.478 no no no no no no 16:0/18:1-PC+blood T-a-MCA+blood 0 0 0.405938352 serum_phospholipids serum_bileacids 6.15E-07 0.478 up up up no no no 16:0/22:6-PC+blood T-a-MCA+blood 0 0 0.524208706 serum_phospholipids serum_bileacids 4.53E-05 0.478 no up up no no no 16:1/16:0-PC+blood T-a-MCA+blood 0 0 0.453985683 serum_phospholipids serum_bileacids 0.0215 0.478 no up up no no no 18:0/18:0-PC+blood T-a-MCA+blood 0 0 0.40101042 serum_phospholipids serum_bileacids 0.426 0.478 no no no no no no 18:0/18:1-PC+blood T-a-MCA+blood 0 0 0.433041975 serum_phospholipids serum_bileacids 0.393 0.478 no no no no no no 18:0/18:2-PC+blood T-a-MCA+blood 0 0 0.52174474 serum_phospholipids serum_bileacids 1.74E-06 0.478 no up up no no no 18:0+blood T-a-MCA+blood 0 0 0.430578009 serum_fattyacid serum_bileacids 0.344 0.478 no no no no no no 18:1/18:0-PC+blood T-a-MCA+blood 0 0 0.489713186 serum_phospholipids serum_bileacids 1.83E-06 0.478 no up up no no no 18:1+blood T-a-MCA+blood 0 0 0.465073529 yes serum_fattyacid serum_bileacids 0.00202 0.478 up no dn no no no 18:2/16:0-PC+blood T-a-MCA+blood 0 0 0.48724922 serum_phospholipids serum_bileacids 8.67E-05 0.478 no up up no no no 18:2n6c+blood T-a-MCA+blood 0 0 0.492177152 serum_fattyacid serum_bileacids 0.15 0.478 no no no no no no 18:3n3+blood T-a-MCA+blood 0 0 0.4958731 serum_fattyacid serum_bileacids 0.291 0.478 no no no no no no 20:3/18:0-PC+blood T-a-MCA+blood 0 0 0.436737923 serum_phospholipids serum_bileacids 0.296 0.478 no no no no no no 20:5/18:0-PC+blood T-a-MCA+blood 0 0 0.492177152 serum_phospholipids serum_bileacids 3.97E-06 0.478 no up up no no no 22:1-LPA+blood T-a-MCA+blood 0 0 -0.407170335 serum_phospholipids serum_bileacids 0.00373 0.478 no up up no no no 24:1+blood T-a-MCA+blood 0 0 0.425650077 serum_fattyacid serum_bileacids 0.00582 0.478 no dn dn no no no 3-(3-Hydroxyphenyl)propanoic acid+stool T-a-MCA+blood 0 0 -0.463260862 stool_cometabolism serum_bileacids 0.33 0.478 no no no no no no CDCA+blood T-a-MCA+blood 0 0 -0.429346026 serum_bileacids serum_bileacids 0.506 0.478 no no no no no no Coronavirus disease - COVID-19 T-a-MCA+blood 0 0 0.488377015 kegg serum_bileacids NA 0.478 no no no no no no GCDCA+blood T-a-MCA+blood 0 0 -0.439201889 serum_bileacids serum_bileacids 0.31 0.478 no no no no no no HIF-1 signaling pathway T-a-MCA+blood 0 0 0.440016111 kegg serum_bileacids NA 0.478 no no no no no no L-2-Aminobutyric acid+blood T-a-MCA+blood 0 0 0.405938352 yes serum_aminoacids serum_bileacids 0.000328 0.478 up up no no no no L-Arginine+blood T-a-MCA+blood 0 0 0.449057752 serum_aminoacids serum_bileacids 0.316 0.478 no no no no no no L-Glutamine+blood T-a-MCA+blood 0 0 0.458913615 serum_aminoacids serum_bileacids 0.639 0.478 no no no no no no Lachnobacterium T-a-MCA+blood 0 0 0.50449698 Genus serum_bileacids 0.867 0.478 no no no no no no Leishmaniasis T-a-MCA+blood 0 0 0.4018723 kegg serum_bileacids NA 0.478 no no no no no no Methanobrevibacter T-a-MCA+blood 0 0 0.559977798 Genus serum_bileacids 0.629 0.478 no no no no no no mTOR signaling pathway T-a-MCA+blood 0 0 0.422987624 kegg serum_bileacids NA 0.478 no no no no no no MUFA+blood T-a-MCA+blood 0 0 0.466305512 serum_fattyacid serum_bileacids 0.00175 0.478 up no dn no no no n6+blood T-a-MCA+blood 0 0 0.434273957 serum_fattyacid serum_bileacids 0.153 0.478 no no no no no no Odoribacter T-a-MCA+blood 0 0 -0.415696089 butyrate-producing Genus serum_bileacids 0.798 0.478 no no no no no no PUFA+blood T-a-MCA+blood 0 0 0.484785255 serum_fattyacid serum_bileacids 0.212 0.478 no no no no no no Ribosome T-a-MCA+blood 0 0 0.488377015 kegg serum_bileacids NA 0.478 no no no no no no 5-Hydroxytryptamine+stool T-¦Á-MCA+stool 0 0.578273758 0 stool_cometabolism stool_bileacids 0.00862 0.48 dn dn no no no no Butyric acid+stool T-¦Á-MCA+stool 0.603544438 0 0 yes stool_scfa stool_bileacids 0.102 0.48 dn no no no no no CA+stool T-¦Á-MCA+stool -0.561751136 -0.697600089 0 stool_bileacids stool_bileacids 0.827 0.48 no no no no no no GCA+stool T-¦Á-MCA+stool 0 0 -0.423603135 stool_bileacids stool_bileacids 0.0809 0.48 no no no no no no GDCA+stool T-¦Á-MCA+stool 0 0 -0.452792834 stool_bileacids stool_bileacids 0.656 0.48 no no no no no no HDCA+stool T-¦Á-MCA+stool 0.528562338 0 0 stool_bileacids stool_bileacids 0.176 0.48 no no no no no no iso-DCA+stool T-¦Á-MCA+stool 0.603544438 0 0 stool_bileacids stool_bileacids 0.155 0.48 no no no no no no iso-LCA+stool T-¦Á-MCA+stool 0 0.642526398 0 stool_bileacids stool_bileacids 0.72 0.48 no no no no no no Kynurenic acid+stool T-¦Á-MCA+stool 0.556834278 0 0 stool_cometabolism stool_bileacids 0.037 0.48 dn dn no no no no L-Tyrosine+stool T-¦Á-MCA+stool 0 0.660884295 0 stool_cometabolism stool_bileacids 0.44 0.48 no no no no no no LCA+stool T-¦Á-MCA+stool 0.478164534 0 0 stool_bileacids stool_bileacids 0.314 0.48 no no no no no no nutriCA+stool T-¦Á-MCA+stool -0.500290399 -0.721017823 0 stool_bileacids stool_bileacids 0.481 0.48 no no no no no no 2-Oxocarboxylic acid metabolism Taste transduction 0 0.526679842 0.437323037 kegg kegg NA NA no no no no no up ABC transporters Taste transduction 0 0 0.588931789 kegg kegg NA NA no up up no no up "Alanine, aspartate and glutamate metabolism" Taste transduction 0 0 -0.431145431 kegg kegg NA NA no no no no no up Amino sugar and nucleotide sugar metabolism Taste transduction 0 0.511857708 0.413642214 kegg kegg NA NA no no no no no up Aminoacyl-tRNA biosynthesis Taste transduction 0 0.834980237 0.574517375 kegg kegg NA NA no no no no no up AMPK signaling pathway Taste transduction 0 0 -0.452509653 kegg kegg NA NA no no no no no up Antifolate resistance Taste transduction 0 0.665019763 0.513256113 kegg kegg NA NA no no no no no up Antigen processing and presentation Taste transduction 0 0 -0.571943372 kegg kegg NA NA no no no no no up Apoptosis Taste transduction 0 -0.72826087 0 kegg kegg NA NA no no no no no up Apoptosis - multiple species Taste transduction 0 0 0.440669241 kegg kegg NA NA no no no no no up Arachidonic acid metabolism Taste transduction 0 0 -0.454054054 kegg kegg NA NA no no no no no up Arginine and proline metabolism Taste transduction 0 -0.559288538 -0.403088803 kegg kegg NA NA no up no no no up Arginine biosynthesis Taste transduction 0 -0.431818182 -0.580952381 kegg kegg NA NA no no no no no up Ascorbate and aldarate metabolism Taste transduction 0 0 0.649420849 kegg kegg NA NA no no no no no up Autophagy - animal Taste transduction 0 -0.437747036 0 kegg kegg NA NA no no no no no up Autophagy - other Taste transduction 0 0 0.528185328 kegg kegg NA NA no no no no no up Axon guidance Taste transduction 0 -0.631422925 0 kegg kegg NA NA no up up no no up B cell receptor signaling pathway Taste transduction -0.424347826 -0.719367589 0 kegg kegg NA NA no no no no no up Basal transcription factors Taste transduction 0 0.747035573 0.676447876 kegg kegg NA NA no no no no no up Base excision repair Taste transduction 0 0.716403162 0.57014157 kegg kegg NA NA no no no no no up beta-Alanine metabolism Taste transduction 0 0.433794466 0 kegg kegg NA NA no no no no no up Biosynthesis of amino acids Taste transduction 0 -0.557312253 -0.642471042 kegg kegg NA NA no no no no no up Biosynthesis of cofactors Taste transduction 0 0.66798419 -0.424453024 kegg kegg NA NA no no no no no up Biosynthesis of unsaturated fatty acids Taste transduction 0.480869565 0.429841897 0 kegg kegg NA NA no no no no no up Butanoate metabolism Taste transduction 0 0.674901186 0 kegg kegg NA NA no no no no no up C-type lectin receptor signaling pathway Taste transduction 0 -0.700592885 0 kegg kegg NA NA no no no no no up cAMP signaling pathway Taste transduction 0 -0.666996047 0 yes kegg kegg NA NA no up up no no up Cell adhesion molecules Taste transduction -0.546086957 -0.564229249 -0.406692407 kegg kegg NA NA no no no no no up Cell cycle Taste transduction 0.768695652 0.803359684 0.713770914 kegg kegg NA NA no no no no no up Cellular senescence Taste transduction -0.54173913 -0.651185771 0 kegg kegg NA NA no no no no no up cGMP-PKG signaling pathway Taste transduction 0 -0.668972332 0 kegg kegg NA NA no no no no no up Chemokine signaling pathway Taste transduction 0 -0.711462451 -0.487516088 kegg kegg NA NA no no no no no up Cholinergic synapse Taste transduction 0 0 0.488803089 kegg kegg NA NA no no no no no up Circadian entrainment Taste transduction 0 0 -0.458172458 kegg kegg NA NA no up up no no up Circadian rhythm Taste transduction 0 0.498023715 0.677992278 kegg kegg NA NA no no no no no up Citrate cycle (TCA cycle) Taste transduction 0 0.639328063 0.467696268 kegg kegg NA NA no no no no no up Complement and coagulation cascades Taste transduction 0 -0.583992095 -0.637065637 kegg kegg NA NA no no no no no up Cysteine and methionine metabolism Taste transduction 0.726086957 0.595849802 0 kegg kegg NA NA no no no no no up Cytosolic DNA-sensing pathway Taste transduction 0 -0.599802372 0 kegg kegg NA NA no no no no no up DNA replication Taste transduction 0.540869565 0.818181818 0.601029601 kegg kegg NA NA no no no no no up Drug metabolism - cytochrome P450 Taste transduction 0 0.636363636 0 kegg kegg NA NA no no no no no up Endocytosis Taste transduction -0.504347826 -0.60770751 0 kegg kegg NA NA no no no no no up ErbB signaling pathway Taste transduction 0 0 0.556241956 kegg kegg NA NA no no no no no up Ether lipid metabolism Taste transduction 0 0.553359684 0.642213642 kegg kegg NA NA no no no no no up Fanconi anemia pathway Taste transduction 0.653913043 0.838932806 0.676705277 kegg kegg NA NA no no no no no up Fc epsilon RI signaling pathway Taste transduction 0 -0.644268775 0 kegg kegg NA NA no no no no no up Fc gamma R-mediated phagocytosis Taste transduction 0 -0.501976285 -0.59021879 kegg kegg NA NA no no no no no up Ferroptosis Taste transduction 0 -0.435770751 -0.653796654 kegg kegg NA NA no no no no no up Folate biosynthesis Taste transduction 0.65826087 0 0 kegg kegg NA NA no no no no no up GABAergic synapse Taste transduction 0 0 -0.539253539 kegg kegg NA NA no up up no no up Galactose metabolism Taste transduction 0 0 0.423938224 kegg kegg NA NA no no no no no up Gap junction Taste transduction 0 0 -0.573745174 kegg kegg NA NA no no no no no up Glutamatergic synapse Taste transduction 0 0 -0.625740026 kegg kegg NA NA no up up no no up Glutathione metabolism Taste transduction 0 0 -0.501930502 kegg kegg NA NA no no no no no up Glycerolipid metabolism Taste transduction 0 0 0.86975547 kegg kegg NA NA no no up no no up Glycerophospholipid metabolism Taste transduction 0 0 0.89009009 kegg kegg NA NA no no up no no up "Glycine, serine and threonine metabolism" Taste transduction 0 0.511857708 -0.475160875 kegg kegg NA NA no up no no no up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Taste transduction -0.472173913 0 0 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Taste transduction 0 0 0.69009009 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - keratan sulfate Taste transduction 0 0 0.421364221 kegg kegg NA NA no no no no no up Glycosaminoglycan degradation Taste transduction -0.450434783 -0.470355731 0.492149292 kegg kegg NA NA no no up no no up Glycosphingolipid biosynthesis - ganglio series Taste transduction 0 0.563241107 0.497297297 kegg kegg NA NA no no no no no up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Taste transduction 0.542608696 0.590909091 0.458687259 kegg kegg NA NA no no no no no up Glyoxylate and dicarboxylate metabolism Taste transduction 0 -0.477272727 -0.52998713 kegg kegg NA NA no no no no no up Hedgehog signaling pathway Taste transduction 0 0.772727273 0.865379665 kegg kegg NA NA no no no no no up Hippo signaling pathway - multiple species Taste transduction 0 0 0.478249678 kegg kegg NA NA no no no no no up Homologous recombination Taste transduction 0.665217391 0.677865613 0.578120978 kegg kegg NA NA no no no no no up IL-17 signaling pathway Taste transduction 0 -0.698616601 -0.595366795 kegg kegg NA NA no no no no no up Inositol phosphate metabolism Taste transduction 0 0 0.885714286 kegg kegg NA NA no no no no no up Intestinal immune network for IgA production Taste transduction -0.572173913 0 0 kegg kegg NA NA no no no no no up Leukocyte transendothelial migration Taste transduction 0 0 -0.450965251 kegg kegg NA NA no no no no no up Linoleic acid metabolism Taste transduction 0 0.516798419 0 kegg kegg NA NA no no no no no up Long-term depression Taste transduction 0 0 -0.424710425 kegg kegg NA NA no no no no no up Long-term potentiation Taste transduction 0.426956522 0.476284585 0.415958816 kegg kegg NA NA no no up no no up Longevity regulating pathway - multiple species Taste transduction 0.622608696 0 0 kegg kegg NA NA no no no no no up Lysine degradation Taste transduction 0 0.423913043 0.86975547 kegg kegg NA NA no no no no no up Lysosome Taste transduction -0.511304348 -0.703557312 0 kegg kegg NA NA no no no no no up Mannose type O-glycan biosynthesis Taste transduction 0 0 0.825225225 kegg kegg NA NA no no no no no up MAPK signaling pathway Taste transduction 0.650434783 0 0.436808237 kegg kegg NA NA no no no no no up Metabolism of xenobiotics by cytochrome P450 Taste transduction 0 0.585968379 0 kegg kegg NA NA no no no no no up Mismatch repair Taste transduction 0.548695652 0.82312253 0 kegg kegg NA NA no no no no no up mRNA surveillance pathway Taste transduction 0 0 0.693693694 kegg kegg NA NA no no no no no up Mucin type O-glycan biosynthesis Taste transduction 0.643478261 0 0 kegg kegg NA NA no no no no no up N-Glycan biosynthesis Taste transduction 0.511304348 0.591897233 0.656628057 kegg kegg NA NA no no no no no up Natural killer cell mediated cytotoxicity Taste transduction -0.480869565 -0.613636364 0 kegg kegg NA NA no no no no no up Necroptosis Taste transduction 0 0 -0.647876448 kegg kegg NA NA no no no no no up Neuroactive ligand-receptor interaction Taste transduction 0 -0.517786561 -0.496525097 kegg kegg NA NA up up up no no up Neurotrophin signaling pathway Taste transduction 0 -0.753952569 0 kegg kegg NA NA no no no no no up Neutrophil extracellular trap formation Taste transduction 0 -0.555335968 -0.638867439 kegg kegg NA NA no no no no no up NF-kappa B signaling pathway Taste transduction 0 -0.488142292 0 kegg kegg NA NA no no no no no up Nicotinate and nicotinamide metabolism Taste transduction 0 -0.502964427 -0.429343629 kegg kegg NA NA no no no no no up Nitrogen metabolism Taste transduction 0 -0.502964427 -0.63989704 kegg kegg NA NA no no no no no up NOD-like receptor signaling pathway Taste transduction 0 -0.526679842 0 kegg kegg NA NA no no no no no up Non-homologous end-joining Taste transduction 0 0.433794466 0 kegg kegg NA NA no no no no no up Notch signaling pathway Taste transduction 0 0 0.766537967 kegg kegg NA NA no no no no no up Nucleotide excision repair Taste transduction 0.612173913 0.896245059 0.501415701 kegg kegg NA NA no no no no no up Olfactory transduction Taste transduction 0 0 -0.416731017 kegg kegg NA NA no no no no no up One carbon pool by folate Taste transduction 0.716521739 0.859683794 0.773487773 kegg kegg NA NA no no no no no up Oocyte meiosis Taste transduction 0.59826087 0.440711462 0 kegg kegg NA NA no no no no no up Osteoclast differentiation Taste transduction 0 -0.615612648 -0.520978121 kegg kegg NA NA no no no no no up Other glycan degradation Taste transduction 0 0 0.771685972 kegg kegg NA NA no no no no no up Other types of O-glycan biosynthesis Taste transduction 0 0.495059289 0.872844273 kegg kegg NA NA no no no no no up p53 signaling pathway Taste transduction 0 0 0.504247104 kegg kegg NA NA no no no no no up Pentose and glucuronate interconversions Taste transduction 0.55826087 0.653162055 0.525868726 kegg kegg NA NA no no no no no up Pentose phosphate pathway Taste transduction -0.419130435 -0.639328063 -0.535392535 kegg kegg NA NA no no no no no up Peroxisome Taste transduction 0 0 -0.481081081 kegg kegg NA NA no no no no no up Phagosome Taste transduction -0.56 -0.62055336 -0.528700129 kegg kegg NA NA no no no no no up Phenylalanine metabolism Taste transduction 0 0.656126482 0 kegg kegg NA NA no no no no no up Phosphatidylinositol signaling system Taste transduction 0 0.621541502 0.82007722 kegg kegg NA NA no no no no no up Phospholipase D signaling pathway Taste transduction -0.494782609 -0.448616601 0 kegg kegg NA NA no up up no no up PI3K-Akt signaling pathway Taste transduction 0.560869565 0 0 yes kegg kegg NA NA no up up no no up Platinum drug resistance Taste transduction 0 0.437747036 0.555727156 kegg kegg NA NA no no no no no up Porphyrin and chlorophyll metabolism Taste transduction 0 0 -0.465637066 kegg kegg NA NA no no no no no up PPAR signaling pathway Taste transduction 0 -0.662055336 -0.597425997 kegg kegg NA NA no no no no no up Primary bile acid biosynthesis Taste transduction 0.534782609 0 0 kegg kegg NA NA no no no no no up Propanoate metabolism Taste transduction 0.62173913 0.529644269 0 kegg kegg NA NA no no no no no up Protein export Taste transduction 0 0 0.498841699 kegg kegg NA NA no no no no no up Protein processing in endoplasmic reticulum Taste transduction 0 0.552371542 0 kegg kegg NA NA no no no no no up Purine metabolism Taste transduction 0 0.494071146 -0.423938224 kegg kegg NA NA no no no no no up Pyrimidine metabolism Taste transduction 0 0.686758893 0.40952381 kegg kegg NA NA no no no no no up Pyruvate metabolism Taste transduction 0.640869565 0.586956522 0 kegg kegg NA NA no no no no no up Ras signaling pathway Taste transduction 0 0 0.586100386 yes kegg kegg NA NA no up up no no up Renin-angiotensin system Taste transduction 0 -0.647233202 0 kegg kegg NA NA no no no no no up Retinol metabolism Taste transduction 0.453913043 0.840909091 0.53024453 kegg kegg NA NA no no no no no up Ribosome biogenesis in eukaryotes Taste transduction 0.476521739 0.874505929 0.761904762 kegg kegg NA NA no no no no no up RIG-I-like receptor signaling pathway Taste transduction 0 -0.552371542 0 kegg kegg NA NA no no no no no up RNA degradation Taste transduction 0 0.459486166 0.750836551 kegg kegg NA NA no no no no no up RNA polymerase Taste transduction 0 0.808300395 0.615444015 kegg kegg NA NA no no no no no up Selenocompound metabolism Taste transduction 0 0.682806324 0.816988417 kegg kegg NA NA no no no no no up Serotonergic synapse Taste transduction 0 0 -0.69034749 kegg kegg NA NA no no no no no up Signaling pathways regulating pluripotency of stem cells Taste transduction 0 0 0.681853282 kegg kegg NA NA no no no no no up SNARE interactions in vesicular transport Taste transduction 0 0 0.440926641 kegg kegg NA NA no no no no no up Sphingolipid metabolism Taste transduction -0.539130435 0 0 kegg kegg NA NA no no no no no up Sphingolipid signaling pathway Taste transduction 0 -0.734189723 0 kegg kegg NA NA no no no no no up Spliceosome Taste transduction 0 0.462450593 0.625740026 kegg kegg NA NA no no no no no up Steroid biosynthesis Taste transduction 0.516521739 0.718379447 0.517117117 kegg kegg NA NA no no no no no up Steroid hormone biosynthesis Taste transduction 0 0.684782609 0.514800515 kegg kegg NA NA no no no no no up Sulfur metabolism Taste transduction 0 0 -0.4996139 kegg kegg NA NA no no no no no up Synaptic vesicle cycle Taste transduction 0 -0.441699605 0 kegg kegg NA NA no up up no no up Synthesis and degradation of ketone bodies Taste transduction 0.671304348 0.843873518 0.475160875 kegg kegg NA NA no no no no no up Taurine and hypotaurine metabolism Taste transduction 0 0 0.661003861 kegg kegg NA NA no no no no no up Terpenoid backbone biosynthesis Taste transduction 0.577391304 0.623517787 0.576319176 kegg kegg NA NA no no no no no up TGF-beta signaling pathway Taste transduction 0 0 0.514028314 kegg kegg NA NA no no no no no up Th1 and Th2 cell differentiation Taste transduction -0.507826087 0 0.422136422 kegg kegg NA NA no no no no no up Th17 cell differentiation Taste transduction -0.42173913 0 0.437580438 kegg kegg NA NA no no no no no up Thiamine metabolism Taste transduction 0.54173913 0 0 kegg kegg NA NA no no no no no up Tight junction Taste transduction 0 0 -0.43011583 kegg kegg NA NA no no no no no up TNF signaling pathway Taste transduction 0 -0.626482213 0 kegg kegg NA NA no no no no no up Toll-like receptor signaling pathway Taste transduction -0.407826087 -0.743083004 0 yes kegg kegg NA NA no no no no no up Tryptophan metabolism Taste transduction 0 0.523715415 0 kegg kegg NA NA no up no no no up Tyrosine metabolism Taste transduction 0 0.773715415 0 kegg kegg NA NA no no no no no up Ubiquinone and other terpenoid-quinone biosynthesis Taste transduction 0.511304348 0.824110672 0.473101673 kegg kegg NA NA no no no no no up "Valine, leucine and isoleucine degradation" Taste transduction 0.42 0.766798419 0.40952381 kegg kegg NA NA no no no no no up Various types of N-glycan biosynthesis Taste transduction 0.414782609 0.476284585 0.614157014 kegg kegg NA NA no no no no no up VEGF signaling pathway Taste transduction 0 -0.555335968 0.418018018 kegg kegg NA NA no no no no no up Viral protein interaction with cytokine and cytokine receptor Taste transduction 0 -0.414031621 -0.526383526 kegg kegg NA NA no no no no no up Wnt signaling pathway Taste transduction 0 0.550395257 0.758043758 kegg kegg NA NA no no no no no up beta-Alanine metabolism Taurine and hypotaurine metabolism 0 -0.505928854 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Taurine and hypotaurine metabolism 0 -0.513833992 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Taurine and hypotaurine metabolism 0 -0.549407115 0 kegg kegg NA NA no no no no no no Fatty acid elongation Taurine and hypotaurine metabolism 0 -0.700592885 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Taurine and hypotaurine metabolism 0 0.681818182 0 kegg kegg NA NA no no no no no no Galactose metabolism Taurine and hypotaurine metabolism 0 0.475296443 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Taurine and hypotaurine metabolism 0 -0.768774704 0 kegg kegg NA NA no no no no no no Lysine degradation Taurine and hypotaurine metabolism 0.414782609 0.649209486 0.592792793 kegg kegg NA NA no no no no no no Oxidative phosphorylation Taurine and hypotaurine metabolism 0 -0.43083004 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Taurine and hypotaurine metabolism 0 -0.445652174 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Taurine and hypotaurine metabolism 0 -0.640316206 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Taurine and hypotaurine metabolism 0 0 0.511454311 kegg kegg NA NA no no no no no no Tryptophan metabolism Taurine and hypotaurine metabolism 0 -0.550395257 0 kegg kegg NA NA no up no no no no 13-HODE+blood Taurine+blood 0 0.678921569 0 serum_ARA serum_aminoacids 0.32 0.857 no no no no no no 14:0/16:0-PC+blood Taurine+blood 0 -0.56127451 0 serum_phospholipids serum_aminoacids 0.0358 0.857 no up no no no no 14:0/20:4-PC+blood Taurine+blood 0 0 -0.405128205 serum_phospholipids serum_aminoacids 0.486 0.857 no no no no no no 16:0/16:1-PI+blood Taurine+blood 0 -0.49754902 0 serum_phospholipids serum_aminoacids 0.262 0.857 no no no no no no 16:0/18:0-PS+blood Taurine+blood 0 -0.512254902 0 serum_phospholipids serum_aminoacids 0.377 0.857 no no no no no no 16:0/18:2-PC+blood Taurine+blood 0 0.539215686 0 serum_phospholipids serum_aminoacids 3.24E-06 0.857 no up up no no no 16:0/20:4-PC+blood Taurine+blood 0.446616541 0 0 serum_phospholipids serum_aminoacids 0.0262 0.857 no up no no no no 16:0/20:4-PI+blood Taurine+blood 0 -0.571078431 0 serum_phospholipids serum_aminoacids 0.558 0.857 no no no no no no 18:0-LPA+blood Taurine+blood 0.583458647 0 0 serum_phospholipids serum_aminoacids 0.0725 0.857 no dn no no no no 18:0-LPC+blood Taurine+blood -0.589473684 0 0 serum_phospholipids serum_aminoacids 0.554 0.857 no no no no no no 18:0/18:0-PS+blood Taurine+blood 0 -0.669117647 0 serum_phospholipids serum_aminoacids 0.00617 0.857 no up no no no no 18:0/18:1-PG+blood Taurine+blood 0 -0.68627451 0 serum_phospholipids serum_aminoacids 0.000842 0.857 no up no no no no 18:0/20:3-PC+blood Taurine+blood -0.589473684 0 0 serum_phospholipids serum_aminoacids 0.0682 0.857 no up no no no no 18:0+blood Taurine+blood -0.473684211 0 0 serum_fattyacid serum_aminoacids 0.344 0.857 no no no no no no 18:1/16:0-PC+blood Taurine+blood 0 0.588235294 0 serum_phospholipids serum_aminoacids 2.43E-05 0.857 no up up no no no 18:2/16:0-PC+blood Taurine+blood 0 0.485294118 0 serum_phospholipids serum_aminoacids 8.67E-05 0.857 no up up no no no 18:3n6+blood Taurine+blood 0 -0.703431373 0 serum_fattyacid serum_aminoacids 0.0463 0.857 up no dn no no no 20:0/20:4-PE+blood Taurine+blood 0 -0.504901961 -0.422222222 serum_phospholipids serum_aminoacids 0.00128 0.857 up up no no no no 20:1-LPE+blood Taurine+blood 0 0 -0.422905983 serum_phospholipids serum_aminoacids 0.465 0.857 no no no no no no 20:1/20:4-PE+blood Taurine+blood 0 -0.625 0 serum_phospholipids serum_aminoacids 0.0042 0.857 up up no no no no 20:2-LPC+blood Taurine+blood 0 0.610294118 0 serum_phospholipids serum_aminoacids 0.119 0.857 no no up no no no 20:2/18:0-PC+blood Taurine+blood -0.578947368 0 0 serum_phospholipids serum_aminoacids 0.0427 0.857 no up no no no no 20:4-LPE+blood Taurine+blood 0 0 -0.421538462 serum_phospholipids serum_aminoacids 0.552 0.857 no no no no no no 20:4/18:0-PE+blood Taurine+blood 0.476691729 0 0 serum_phospholipids serum_aminoacids 0.000755 0.857 up up no no no no 20:5-LPC+blood Taurine+blood 0 0 0.491965812 serum_phospholipids serum_aminoacids 0.558 0.857 no no no no no no 22:2-LPA+blood Taurine+blood 0.508270677 0 0 serum_phospholipids serum_aminoacids 0.0443 0.857 dn no no no no no 22:6-LPC+blood Taurine+blood -0.446616541 0 0.594529915 serum_phospholipids serum_aminoacids 0.127 0.857 no no up no no no 22:6n3+blood Taurine+blood -0.473684211 0 0.474871795 serum_fattyacid serum_aminoacids 0.792 0.857 no no no no no no 8-HETE+blood Taurine+blood 0.50075188 0.81372549 0 serum_ARA serum_aminoacids 0.741 0.857 no no no no no no Acute myeloid leukemia Taurine+blood 0 0 0.537692308 kegg serum_aminoacids NA 0.857 no no no no no no Adherens junction Taurine+blood 0.59122807 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Adipocytokine signaling pathway Taurine+blood 0 0.541176471 0 kegg serum_aminoacids NA 0.857 no no no no no no Alcoholism Taurine+blood -0.461403509 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Allograft rejection Taurine+blood 0 0 -0.466153846 kegg serum_aminoacids NA 0.857 no no no no no no Apoptosis Taurine+blood 0.531578947 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Arrhythmogenic right ventricular cardiomyopathy Taurine+blood 0.570175439 0 0 kegg serum_aminoacids NA 0.857 no up up no no no Autoimmune thyroid disease Taurine+blood 0 0 -0.466153846 kegg serum_aminoacids NA 0.857 no no no no no no B cell receptor signaling pathway Taurine+blood 0 0.508823529 0 kegg serum_aminoacids NA 0.857 no no no no no no Bacterial invasion of epithelial cells Taurine+blood 0.524561404 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Cell adhesion molecules Taurine+blood 0 0 -0.478461538 kegg serum_aminoacids NA 0.857 no no no no no no Cellular senescence Taurine+blood 0 0 -0.51 kegg serum_aminoacids NA 0.857 no no no no no no Central carbon metabolism in cancer Taurine+blood 0 -0.505882353 0 kegg serum_aminoacids NA 0.857 no no no no no no Chemokine signaling pathway Taurine+blood 0 0.591176471 0 kegg serum_aminoacids NA 0.857 no no no no no no Choline+blood Taurine+blood 0 0.5 0 serum_choline serum_aminoacids 0.0395 0.857 no up no no no no Cholinergic synapse Taurine+blood -0.514035088 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Chronic myeloid leukemia Taurine+blood 0 0.502941176 0 kegg serum_aminoacids NA 0.857 no no no no no no Cysteine+blood Taurine+blood 0 0 0.558290598 yes serum_aminoacids serum_aminoacids 1.81E-07 0.857 dn up up no no no Cystine+blood Taurine+blood 0 0 0.473504274 yes serum_aminoacids serum_aminoacids 0.00028 0.857 up up no no no no d18:1-14:0-SM+blood Taurine+blood 0 -0.68872549 0 serum_phospholipids serum_aminoacids 0.94 0.857 no no no no no no d18:1-14:1-SM+blood Taurine+blood 0 -0.509803922 0 serum_phospholipids serum_aminoacids 0.0952 0.857 no dn no no no no Dilated cardiomyopathy Taurine+blood 0.470175439 0 0 kegg serum_aminoacids NA 0.857 no up up no no no DL-methionine sulfoxide+blood Taurine+blood 0 0 0.562393162 serum_aminoacids serum_aminoacids 0.302 0.857 no no no no no no Epithelial cell signaling in Helicobacter pylori infection Taurine+blood 0 0.564705882 0 kegg serum_aminoacids NA 0.857 no no no no no no Ethanolamine+blood Taurine+blood 0.580451128 0.693627451 0 serum_aminoacids serum_aminoacids 0.122 0.857 up no no no no no Fluid shear stress and atherosclerosis Taurine+blood 0.459649123 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Focal adhesion Taurine+blood 0.50877193 0 0 kegg serum_aminoacids NA 0.857 no up up no no no GABAergic synapse Taurine+blood -0.531578947 0 0 kegg serum_aminoacids NA 0.857 no up up no no no Glucagon signaling pathway Taurine+blood -0.468421053 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Glutamatergic synapse Taurine+blood -0.466666667 0 0 kegg serum_aminoacids NA 0.857 no up up no no no Glycine+blood Taurine+blood 0.518796992 0.75 0 serum_aminoacids serum_aminoacids 0.00408 0.857 dn no up no no no GnRH signaling pathway Taurine+blood -0.640350877 0 0 kegg serum_aminoacids NA 0.857 no no no no no no GPC+blood Taurine+blood 0 0.651960784 0 serum_choline serum_aminoacids 0.00427 0.857 no up up no no no Graft-versus-host disease Taurine+blood 0 0 -0.459230769 kegg serum_aminoacids NA 0.857 no no no no no no Hepatocellular carcinoma Taurine+blood 0.538596491 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Hippo signaling pathway Taurine+blood 0.545614035 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Human T-cell leukemia virus 1 infection Taurine+blood 0 0 -0.408461538 kegg serum_aminoacids NA 0.857 no no no no no no Hypertrophic cardiomyopathy Taurine+blood 0.561403509 0 0 kegg serum_aminoacids NA 0.857 no up up no no no Hypotaurine+blood Taurine+blood 0.616541353 0.68872549 0 serum_aminoacids serum_aminoacids 0.933 0.857 no no no no no no Influenza A Taurine+blood 0.459649123 0 0 kegg serum_aminoacids NA 0.857 no no no no no no L-Asparagine+blood Taurine+blood 0 0.75 0 serum_aminoacids serum_aminoacids 0.784 0.857 no no no no no no L-Aspartic acid+blood Taurine+blood 0.461654135 0.725490196 0 yes serum_aminoacids serum_aminoacids 0.0226 0.857 up up no no no no L-Citrulline+blood Taurine+blood 0 0.534313725 0 serum_aminoacids serum_aminoacids 0.534 0.857 no no no no no no L-Glutamine+blood Taurine+blood 0 0.556372549 0 serum_aminoacids serum_aminoacids 0.639 0.857 no no no no no no L-Histidine+blood Taurine+blood 0 0.647058824 0 serum_aminoacids serum_aminoacids 0.109 0.857 no no no no no no L-Isoleucine+blood Taurine+blood 0 0 0.551452991 yes serum_aminoacids serum_aminoacids 5.47E-06 0.857 up up no no no no L-Lysine+blood Taurine+blood 0 0.5 0.472820513 yes serum_aminoacids serum_aminoacids 0.0107 0.857 no up no no no no L-Methionine+blood Taurine+blood 0 0 0.428376068 serum_aminoacids serum_aminoacids 0.626 0.857 no no no no no no L-Ornithine+blood Taurine+blood 0 0.482843137 0.475555556 serum_aminoacids serum_aminoacids 0.175 0.857 no no no no no no L-Phenylalanine+blood Taurine+blood 0 0 0.682051282 yes serum_aminoacids serum_aminoacids 0.0103 0.857 up up no no no no L-Threonine+blood Taurine+blood 0 0.487745098 0 serum_aminoacids serum_aminoacids 0.0538 0.857 dn no up no no no Leukocyte transendothelial migration Taurine+blood 0.5 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Long-term potentiation Taurine+blood -0.559649123 0 0 kegg serum_aminoacids NA 0.857 no no up no no no n3+blood Taurine+blood 0 0 0.562393162 serum_fattyacid serum_aminoacids 0.806 0.857 no no no no no no Oocyte meiosis Taurine+blood 0 -0.588235294 0 kegg serum_aminoacids NA 0.857 no no no no no no Oxytocin signaling pathway Taurine+blood 0.492982456 0 0 kegg serum_aminoacids NA 0.857 no no no no no no p53 signaling pathway Taurine+blood -0.524561404 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Paraprevotella Taurine+blood 0.519368197 0 0 Genus serum_aminoacids 0.118 0.857 no no no no no no Pathogenic Escherichia coli infection Taurine+blood 0.756140351 0.502941176 0 kegg serum_aminoacids NA 0.857 no no no no no no Phosphatidylinositol signaling system Taurine+blood 0 -0.570588235 0 kegg serum_aminoacids NA 0.857 no no no no no no Platinum drug resistance Taurine+blood -0.529824561 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Prevotella Taurine+blood 0.493567647 0 0 Genus serum_aminoacids 0.367 0.857 no no no no no no Prostate cancer Taurine+blood 0 0.529411765 0 kegg serum_aminoacids NA 0.857 no no no no no no PUFA/MUFA+blood Taurine+blood 0 0.583333333 0 serum_fattyacid serum_aminoacids 0.00108 0.857 dn no up no no no PUFA/UFA+blood Taurine+blood 0 0.661764706 0 serum_fattyacid serum_aminoacids 0.000732 0.857 dn no up no no no PUFA%+blood Taurine+blood 0 0.674019608 0 serum_fattyacid serum_aminoacids 0.0013 0.857 dn no up no no no Rap1 signaling pathway Taurine+blood 0.573684211 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Regulation of actin cytoskeleton Taurine+blood 0.496491228 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Relaxin signaling pathway Taurine+blood 0 0.538235294 0 kegg serum_aminoacids NA 0.857 no no no no no no Salmonella infection Taurine+blood 0.554385965 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Serine+blood Taurine+blood 0 0.607843137 0 serum_aminoacids serum_aminoacids 0.942 0.857 no no no no no no Thyroid hormone signaling pathway Taurine+blood 0.456140351 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Tight junction Taurine+blood 0.522807018 0 0 kegg serum_aminoacids NA 0.857 no no no no no no TNF signaling pathway Taurine+blood 0 0.535294118 0 kegg serum_aminoacids NA 0.857 no no no no no no Type I diabetes mellitus Taurine+blood 0 0 -0.472307692 kegg serum_aminoacids NA 0.857 no no no no no no Vibrio cholerae infection Taurine+blood 0.577192982 0 0 kegg serum_aminoacids NA 0.857 no no no no no no Viral carcinogenesis Taurine+blood 0 0 -0.436153846 kegg serum_aminoacids NA 0.857 no no no no no no Viral myocarditis Taurine+blood 0.485964912 0 -0.417692308 kegg serum_aminoacids NA 0.857 no no no no no no Yersinia infection Taurine+blood 0.585964912 0 0 kegg serum_aminoacids NA 0.857 no no no no no no 13-HODE+blood TBIL+clinic 0 0.635714286 0 serum_ARA clinic 0.32 0.171 no no no no no no 14:0/18:2-PC+blood TBIL+clinic 0 0 -0.526153846 serum_phospholipids clinic 0.102 0.171 no up no no no no 14:0/20:4-PC+blood TBIL+clinic 0 0 -0.622307692 serum_phospholipids clinic 0.486 0.171 no no no no no no 16:0/18:2-PI+blood TBIL+clinic 0 0 -0.513846154 serum_phospholipids clinic 0.269 0.171 no no no no no no 16:0/20:4-PI+blood TBIL+clinic 0 0 -0.463076923 serum_phospholipids clinic 0.558 0.171 no no no no no no 16:0/22:6-PC+blood TBIL+clinic 0 0 0.435384615 serum_phospholipids clinic 4.53E-05 0.171 no up up no no no 16:1/16:0-PC+blood TBIL+clinic 0 0.557142857 0.456923077 serum_phospholipids clinic 0.0215 0.171 no up up no no no 18:0/18:0-PS+blood TBIL+clinic 0 -0.517857143 0 serum_phospholipids clinic 0.00617 0.171 no up no no no no 18:1/16:0-PC+blood TBIL+clinic 0 0 0.406153846 serum_phospholipids clinic 2.43E-05 0.171 no up up no no no 18:2/16:0-PC+blood TBIL+clinic 0 0.610714286 0 serum_phospholipids clinic 8.67E-05 0.171 no up up no no no 18:3n6+blood TBIL+clinic 0 -0.528571429 -0.56 serum_fattyacid clinic 0.0463 0.171 up no dn no no no 20:3n6+blood TBIL+clinic 0 0 -0.472307692 serum_fattyacid clinic 0.0884 0.171 up no no no no no 8-HETE+blood TBIL+clinic 0 0.7 0 serum_ARA clinic 0.741 0.171 no no no no no no Betaine+blood TBIL+clinic 0 0 0.424615385 serum_choline clinic 0.857 0.171 no no no no no no Central carbon metabolism in cancer TBIL+clinic 0 -0.593506494 0 kegg clinic NA 0.171 no no no no no no Coronavirus disease - COVID-19 TBIL+clinic 0 -0.450649351 0 kegg clinic NA 0.171 no no no no no no Creatinine+blood TBIL+clinic 0 0 0.662307692 serum_choline clinic 0.437 0.171 no no no no no no d18:1-14:0-SM+blood TBIL+clinic 0 -0.542857143 0 serum_phospholipids clinic 0.94 0.171 no no no no no no d18:1-16:1-SM+blood TBIL+clinic 0 0 -0.473076923 serum_phospholipids clinic 0.2 0.171 no no no no no no d18:1-22:1-SM+blood TBIL+clinic 0 0 -0.443076923 serum_phospholipids clinic 0.222 0.171 no no no no no no Eotaxin TBIL+clinic 0 0.489473684 0 serum_cytokines clinic 0.393 0.171 no no no no no no GDCA+stool TBIL+clinic 0 0 -0.456933088 stool_bileacids clinic 0.656 0.171 no no no no no no HIF-1 signaling pathway TBIL+clinic 0 -0.477922078 0 kegg clinic NA 0.171 no no no no no no IL-9 TBIL+clinic 0 0.610526316 0 serum_cytokines clinic 0.906 0.171 no no no no no no Insulin signaling pathway TBIL+clinic 0 -0.448051948 0 kegg clinic NA 0.171 no no no no no no L-Asparagine+blood TBIL+clinic 0 0 0.696153846 serum_aminoacids clinic 0.784 0.171 no no no no no no L-Glutamine+blood TBIL+clinic 0 0 0.719230769 serum_aminoacids clinic 0.639 0.171 no no no no no no L-Histidine+blood TBIL+clinic 0 0 0.555384615 serum_aminoacids clinic 0.109 0.171 no no no no no no Legionellosis TBIL+clinic 0 -0.454545455 0 kegg clinic NA 0.171 no no no no no no Leptin TBIL+clinic 0 0 -0.462796028 DM-assocaited hormones clinic 0.706 0.171 no no no no no no MUFA%+blood TBIL+clinic 0 0 0.500769231 serum_fattyacid clinic 0.00142 0.171 up no dn no no no n6+blood TBIL+clinic 0 0 -0.400769231 serum_fattyacid clinic 0.153 0.171 no no no no no no nutriCA+stool TBIL+clinic 0 -0.642370687 0 stool_bileacids clinic 0.481 0.171 no no no no no no Phenylacetyl L-GlutaMine+urine TBIL+clinic 0 0.487745098 0 urine_cometabolism clinic 0.0909 0.171 up no no no no no PUFA%+blood TBIL+clinic 0 0 0.460769231 serum_fattyacid clinic 0.0013 0.171 dn no up no no no RANTES TBIL+clinic 0 0.559649123 0 yes serum_cytokines clinic 0.0757 0.171 no no up no no no Renal cell carcinoma TBIL+clinic 0 -0.463636364 0 kegg clinic NA 0.171 no no no no no no Ribosome TBIL+clinic 0 -0.446753247 0 kegg clinic NA 0.171 no no no no no no Serine+blood TBIL+clinic 0 0 0.523846154 serum_aminoacids clinic 0.942 0.171 no no no no no no SFA%+blood TBIL+clinic 0 0 0.507692308 serum_fattyacid clinic 0.0236 0.171 no up no no no no Taurine+blood TBIL+clinic 0 0.682142857 0 serum_aminoacids clinic 0.857 0.171 no no no no no no TXB2+blood TBIL+clinic 0 0.621521613 0 yes serum_ARA clinic 0.0644 0.171 dn no no no no no UFA%+blood TBIL+clinic 0 0 0.537692308 serum_fattyacid clinic 0.0236 0.171 no dn no no no no 12-ketoDCA+stool TCA+blood 0 0.650492813 0 stool_bileacids serum_bileacids 0.505 0.339 no no no no no no 15-HETE+blood TCA+blood -0.465445979 0 0 serum_ARA serum_bileacids 0.819 0.339 no no no no no no 16:0/16:0-PI+blood TCA+blood 0 0.490157248 0 serum_phospholipids serum_bileacids 0.358 0.339 no no no no no no 16:0/22:6-PC+blood TCA+blood 0 -0.485077898 0 serum_phospholipids serum_bileacids 4.53E-05 0.339 no up up no no no 18:0/16:0-PC+blood TCA+blood -0.463509693 0 0 serum_phospholipids serum_bileacids 9.64E-07 0.339 up up up no no no 18:0/18:2-PI+blood TCA+blood 0 -0.525712696 0 serum_phospholipids serum_bileacids 0.179 0.339 no no no no no no 18:0/20:2-PC+blood TCA+blood 0.479275329 0 0 serum_phospholipids serum_bileacids 0.733 0.339 no no no no no no 18:0/20:3-PC+blood TCA+blood 0.509230037 0 0 serum_phospholipids serum_bileacids 0.0682 0.339 no up no no no no 18:0/20:4-PI+blood TCA+blood 0 -0.485077898 0 serum_phospholipids serum_bileacids 0.167 0.339 no no no no no no 20:1-LPE+blood TCA+blood 0 -0.513014322 0 serum_phospholipids serum_bileacids 0.465 0.339 no no no no no no 20:2/18:0-PC+blood TCA+blood 0.502923782 0 0 serum_phospholipids serum_bileacids 0.0427 0.339 no up no no no no 20:3/18:0-PC+blood TCA+blood 0 -0.490157248 0 serum_phospholipids serum_bileacids 0.296 0.339 no no no no no no 20:3n6+blood TCA+blood 0.529725363 0 0 serum_fattyacid serum_bileacids 0.0884 0.339 up no no no no no 20:4-LPA+blood TCA+blood -0.518689418 0 0.402918348 serum_phospholipids serum_bileacids 0.398 0.339 no no no no no no 20:4-LPE+blood TCA+blood -0.520265982 0 0 serum_phospholipids serum_bileacids 0.552 0.339 no no no no no no 20:4n6+blood TCA+blood -0.542337872 0 0 serum_fattyacid serum_bileacids 0.133 0.339 no no no no no no 20:5-LPC+blood TCA+blood 0 0 -0.542805051 serum_phospholipids serum_bileacids 0.558 0.339 no no no no no no 20:5/18:0-PC+blood TCA+blood 0 -0.594283918 0 serum_phospholipids serum_bileacids 3.97E-06 0.339 no up up no no no 22:6-LPC+blood TCA+blood 0 0 -0.437890024 serum_phospholipids serum_bileacids 0.127 0.339 no no up no no no 5-HETE+blood TCA+blood -0.570499954 0 0 serum_ARA serum_bileacids 0.697 0.339 no no no no no no Alcoholism TCA+blood 0 -0.509672654 0 kegg serum_bileacids NA 0.339 no no no no no no Allograft rejection TCA+blood 0 -0.518883606 0 kegg serum_bileacids NA 0.339 no no no no no no Amphetamine addiction TCA+blood 0 0.518883606 0 kegg serum_bileacids NA 0.339 no no no no no no Autoimmune thyroid disease TCA+blood 0 -0.518883606 0 kegg serum_bileacids NA 0.339 no no no no no no Biosynthesis of amino acids TCA+blood 0 -0.506602337 0 kegg serum_bileacids NA 0.339 no no no no no no Cell adhesion molecules TCA+blood 0 -0.537305509 0 kegg serum_bileacids NA 0.339 no no no no no no Cellular senescence TCA+blood 0 -0.614063438 0 kegg serum_bileacids NA 0.339 no no no no no no Clostridium TCA+blood 0.477089874 0 0 Genus serum_bileacids 0.925 0.339 no no no no no no d18:0-16:0-SM+blood TCA+blood -0.457203438 0 0 serum_phospholipids serum_bileacids 0.202 0.339 no no no no no no d18:1-16:0-SM+blood TCA+blood -0.474545638 0 0 serum_phospholipids serum_bileacids 0.14 0.339 no no no no no no d18:1-18:0-SM+blood TCA+blood -0.523419109 0 0 serum_phospholipids serum_bileacids 0.97 0.339 no no no no no no d18:1-18:1-SM+blood TCA+blood -0.526572236 0 0 serum_phospholipids serum_bileacids 0.916 0.339 no no no no no no d18:1-20:1-SM+blood TCA+blood -0.465086256 0 0 serum_phospholipids serum_bileacids 0.0992 0.339 no no no no no no DCA+blood TCA+blood 0 0 -0.428961085 serum_bileacids serum_bileacids 0.122 0.339 no no no no no no DHA+blood TCA+blood 0 0 -0.53908466 serum_ARA serum_bileacids 0.872 0.339 no no no no no no DPA+blood TCA+blood 0 0 -0.411847287 serum_ARA serum_bileacids 0.519 0.339 no no no no no no Endocytosis TCA+blood 0 -0.598711853 0 kegg serum_bileacids NA 0.339 no no no no no no EPA+blood TCA+blood 0 0 -0.506345219 serum_ARA serum_bileacids 0.212 0.339 no no no no no no Fluid shear stress and atherosclerosis TCA+blood -0.523029991 0 0 kegg serum_bileacids NA 0.339 no no no no no no Focal adhesion TCA+blood -0.545286586 0 0 kegg serum_bileacids NA 0.339 no up up no no no Gastric acid secretion TCA+blood -0.4785168 0 0 kegg serum_bileacids NA 0.339 no no no no no no GCA+blood TCA+blood 0.476122201 0.911743275 0.649952312 yes serum_bileacids serum_bileacids 0.16 0.339 no no no no no no GCDCA+blood TCA+blood 0 0.72634701 0 serum_bileacids serum_bileacids 0.31 0.339 no no no no no no Graft-versus-host disease TCA+blood 0 -0.518883606 0 kegg serum_bileacids NA 0.339 no no no no no no GUDCA+blood TCA+blood 0 0.490157248 0 serum_bileacids serum_bileacids 0.0766 0.339 no no dn no no no Hepatocellular carcinoma TCA+blood -0.461824354 0 0 kegg serum_bileacids NA 0.339 no no no no no no Hippo signaling pathway TCA+blood -0.508192261 0 0 kegg serum_bileacids NA 0.339 no no no no no no Human papillomavirus infection TCA+blood 0 -0.641696293 -0.418059367 kegg serum_bileacids NA 0.339 no no no no no no L-2-Aminobutyric acid+blood TCA+blood 0 0 0.456864018 yes serum_aminoacids serum_bileacids 0.000328 0.339 up up no no no no L-Arginine+blood TCA+blood 0.465086256 0 0 serum_aminoacids serum_bileacids 0.316 0.339 no no no no no no Leukocyte transendothelial migration TCA+blood -0.471097935 0 0 kegg serum_bileacids NA 0.339 no no no no no no Methanobrevibacter TCA+blood 0 0.575846774 0 Genus serum_bileacids 0.629 0.339 no no no no no no Natural killer cell mediated cytotoxicity TCA+blood 0 -0.589500901 0 kegg serum_bileacids NA 0.339 no no no no no no Oxytocin signaling pathway TCA+blood -0.472952651 0 0 kegg serum_bileacids NA 0.339 no no no no no no Pathogenic Escherichia coli infection TCA+blood -0.524884707 0 0 kegg serum_bileacids NA 0.339 no no no no no no Platelet activation TCA+blood -0.467388503 0 0 kegg serum_bileacids NA 0.339 no no no no no no Porphyrin and chlorophyll metabolism TCA+blood 0 0.518883606 0 kegg serum_bileacids NA 0.339 no no no no no no Rap1 signaling pathway TCA+blood -0.495209247 0 0 kegg serum_bileacids NA 0.339 no no no no no no Regulation of actin cytoskeleton TCA+blood -0.523029991 0 0 kegg serum_bileacids NA 0.339 no no no no no no Salmonella infection TCA+blood -0.497063963 0 0 kegg serum_bileacids NA 0.339 no no no no no no Systemic lupus erythematosus TCA+blood 0 0 0.408105572 kegg serum_bileacids NA 0.339 no no no no no no Taurine+blood TCA+blood -0.610130106 0 0 serum_aminoacids serum_bileacids 0.857 0.339 no no no no no no Thyroid hormone signaling pathway TCA+blood -0.530448856 0 0 kegg serum_bileacids NA 0.339 no no no no no no Type I diabetes mellitus TCA+blood 0 -0.518883606 0 kegg serum_bileacids NA 0.339 no no no no no no Vibrio cholerae infection TCA+blood -0.469243219 0 0 kegg serum_bileacids NA 0.339 no no no no no no Viral carcinogenesis TCA+blood 0 -0.592571218 0 kegg serum_bileacids NA 0.339 no no no no no no Adherens junction TCA+stool 0 0.756266199 0 kegg stool_bileacids NA 0.458 no no no no no no Alzheimer disease TCA+stool 0 0.678817251 0 kegg stool_bileacids NA 0.458 no no no no no no Amyotrophic lateral sclerosis TCA+stool 0 0.605924123 0 kegg stool_bileacids NA 0.458 no no no no no no Anaerostipes TCA+stool 0.585492228 0 0 butyrate-producing Genus stool_bileacids 0.568 0.458 no no no no no no Arginine and proline metabolism TCA+stool 0.476733181 0 0 kegg stool_bileacids NA 0.458 no up no no no no Arrhythmogenic right ventricular cardiomyopathy TCA+stool 0 0.719819635 0 kegg stool_bileacids NA 0.458 no up up no no no Bacterial invasion of epithelial cells TCA+stool 0 0.815491865 0 kegg stool_bileacids NA 0.458 no no no no no no CA+stool TCA+stool 0 0 0.523715415 stool_bileacids stool_bileacids 0.827 0.458 no no no no no no Caproic acid+stool TCA+stool 0 -0.588442233 0 stool_scfa stool_bileacids 0.882 0.458 no no no no no no CDCA+stool TCA+stool 0 0 0.432806324 stool_bileacids stool_bileacids 0.663 0.458 no no no no no no Cholinergic synapse TCA+stool 0 -0.651482328 0 kegg stool_bileacids NA 0.458 no no no no no no Coprococcus TCA+stool 0.526371343 0 -0.59486166 butyrate-producing Genus stool_bileacids 0.612 0.458 no no no no no no DCA+stool TCA+stool 0 0 -0.531620553 stool_bileacids stool_bileacids 0.195 0.458 no no no no no no Diabetic cardiomyopathy TCA+stool 0 0.678817251 0 kegg stool_bileacids NA 0.458 no no no no no no ErbB signaling pathway TCA+stool 0 -0.66970561 0 kegg stool_bileacids NA 0.458 no no no no no no Fluid shear stress and atherosclerosis TCA+stool 0 0.779045301 0 kegg stool_bileacids NA 0.458 no no no no no no Focal adhesion TCA+stool 0 0.724375456 0 kegg stool_bileacids NA 0.458 no up up no no no FoxO signaling pathway TCA+stool 0 -0.751710379 0 kegg stool_bileacids NA 0.458 no no no no no no GCA+stool TCA+stool 0 0 0.590909091 stool_bileacids stool_bileacids 0.0809 0.458 no no no no no no GCDCA+stool TCA+stool 0 0 0.473320158 yes stool_bileacids stool_bileacids 0.0471 0.458 no dn no no no no GDCA+stool TCA+stool 0 0 0.487636242 stool_bileacids stool_bileacids 0.656 0.458 no no no no no no Hepatocellular carcinoma TCA+stool 0 0.742598738 0 kegg stool_bileacids NA 0.458 no no no no no no Hippo signaling pathway TCA+stool 0 0.715263815 0 kegg stool_bileacids NA 0.458 no no no no no no Huntington disease TCA+stool 0 0.678817251 0 kegg stool_bileacids NA 0.458 no no no no no no Hypertrophic cardiomyopathy TCA+stool 0 0.710707994 0 kegg stool_bileacids NA 0.458 no up up no no no iso-LCA+stool TCA+stool 0 -0.581436969 -0.427865613 stool_bileacids stool_bileacids 0.72 0.458 no no no no no no JAK-STAT signaling pathway TCA+stool 0 -0.605924123 0 kegg stool_bileacids NA 0.458 no no no no no no Lachnospira TCA+stool 0 0.584939601 0 butyrate-producing Genus stool_bileacids 0.279 0.458 no no no no no no LCA+stool TCA+stool -0.524303086 0 -0.447628458 stool_bileacids stool_bileacids 0.314 0.458 no no no no no no Leukocyte transendothelial migration TCA+stool 0 0.774489481 0 kegg stool_bileacids NA 0.458 no no no no no no Longevity regulating pathway - multiple species TCA+stool 0.551190424 0 0 kegg stool_bileacids NA 0.458 no no no no no no MAPK signaling pathway TCA+stool 0 -0.833715147 0 kegg stool_bileacids NA 0.458 no no no no no no Non-alcoholic fatty liver disease TCA+stool 0 0.697040533 0 kegg stool_bileacids NA 0.458 no no no no no no Olfactory transduction TCA+stool 0.542917397 0 0 kegg stool_bileacids NA 0.458 no no no no no no Oxidative phosphorylation TCA+stool 0 0.678817251 0 kegg stool_bileacids NA 0.458 no no no no no no Oxytocin signaling pathway TCA+stool 0 0.815491865 0 kegg stool_bileacids NA 0.458 no no no no no no Parabacteroides TCA+stool 0 -0.588442233 -0.451581028 Genus stool_bileacids 4.19E-05 0.458 no up up no no no Parkinson disease TCA+stool 0 0.687928892 0 kegg stool_bileacids NA 0.458 no no no no no no Pathways of neurodegeneration - multiple diseases TCA+stool 0 0.651482328 0 kegg stool_bileacids NA 0.458 no no no no no no Peroxisome TCA+stool 0.563599964 0 0 kegg stool_bileacids NA 0.458 no no no no no no Platelet activation TCA+stool 0 0.838270968 0 kegg stool_bileacids NA 0.458 no no no no no no Platinum drug resistance TCA+stool 0 -0.710707994 0 kegg stool_bileacids NA 0.458 no no no no no no Primary immunodeficiency TCA+stool 0.470528411 0 0 kegg stool_bileacids NA 0.458 no no no no no no Prion disease TCA+stool 0 0.683373071 0 kegg stool_bileacids NA 0.458 no no no no no no Progesterone-mediated oocyte maturation TCA+stool 0 -0.665149789 0 kegg stool_bileacids NA 0.458 no no no no no no Propionic acid+stool TCA+stool 0 0 -0.530632411 yes stool_scfa stool_bileacids 0.0436 0.458 dn no up no no no Rap1 signaling pathway TCA+stool 0 0.824603506 0 kegg stool_bileacids NA 0.458 no no no no no no Retrograde endocannabinoid signaling TCA+stool 0 0.692484712 0 kegg stool_bileacids NA 0.458 no no up no no no Ruminococcus TCA+stool 0 0 -0.455449543 Genus stool_bileacids 0.0679 0.458 no no dn no no no Ruminococcus TCA+stool -0.472596667 0 0 acetate-producing Genus stool_bileacids 0.335 0.458 no no no no no no Signaling pathways regulating pluripotency of stem cells TCA+stool 0 0 -0.471485037 kegg stool_bileacids NA 0.458 no no no no no no Spliceosome TCA+stool 0 -0.742598738 0 kegg stool_bileacids NA 0.458 no no no no no no T cell receptor signaling pathway TCA+stool 0 -0.76537784 0 kegg stool_bileacids NA 0.458 no no no no no no T-¦Á-MCA+stool TCA+stool 0 0 -0.591949453 stool_bileacids stool_bileacids 0.48 0.458 no no no no no no Th1 and Th2 cell differentiation TCA+stool -0.544985654 0 0 kegg stool_bileacids NA 0.458 no no no no no no Th17 cell differentiation TCA+stool -0.5284396 0 0 kegg stool_bileacids NA 0.458 no no no no no no Thermogenesis TCA+stool 0 0.642370687 0 kegg stool_bileacids NA 0.458 no no no no no no Tight junction TCA+stool 0 0.86105007 0 kegg stool_bileacids NA 0.458 no no no no no no Vascular smooth muscle contraction TCA+stool 0 0.678817251 0 kegg stool_bileacids NA 0.458 no no no no no no Vibrio cholerae infection TCA+stool 0 0.701596353 0 kegg stool_bileacids NA 0.458 no no no no no no 12-ketoDCA+blood TDCA+blood 0.585191892 0 0.441703189 yes serum_bileacids serum_bileacids 0.517 0.155 no no no no up no 14:0-LPC+blood TDCA+blood 0 0.681900196 0 yes serum_phospholipids serum_bileacids 0.00689 0.155 up up no no up no 14:0/18:0-PC+blood TDCA+blood 0.488152779 0 0 yes serum_phospholipids serum_bileacids 0.00289 0.155 up up no no up no 14:0+blood TDCA+blood -0.456531546 0 0 yes yes serum_fattyacid serum_bileacids 0.00572 0.155 up no dn no up no 15-HETE+blood TDCA+blood -0.495847733 0 0 yes serum_ARA serum_bileacids 0.819 0.155 no no no no up no 16:0-LPE+blood TDCA+blood 0.472342162 0 0 yes serum_phospholipids serum_bileacids 0.0711 0.155 up up no no up no 16:0/16:1-PC+blood TDCA+blood 0.446649911 0 0 yes serum_phospholipids serum_bileacids 0.00283 0.155 up up no no up no 16:0/18:1-PC+blood TDCA+blood 0 -0.506280025 0 yes serum_phospholipids serum_bileacids 6.15E-07 0.155 up up up no up no 16:0/20:4-PE+blood TDCA+blood 0.507916049 0 0 yes serum_phospholipids serum_bileacids 0.00139 0.155 up up no no up no 16:1/16:0-PC+blood TDCA+blood 0 -0.526860513 0 yes serum_phospholipids serum_bileacids 0.0215 0.155 no up up no up no 16:1/18:1-PG+blood TDCA+blood 0 -0.540580839 0 yes serum_phospholipids serum_bileacids 3.21E-05 0.155 no up up no up no 16:1/18:2-PG+blood TDCA+blood 0 0 -0.414881707 yes serum_phospholipids serum_bileacids 1.40E-08 0.155 no up up no up no 18:0/16:0-PC+blood TDCA+blood 0 -0.504907992 0 yes serum_phospholipids serum_bileacids 9.64E-07 0.155 up up up no up no 18:0/18:0-PC+blood TDCA+blood 0 -0.488443601 0 yes serum_phospholipids serum_bileacids 0.426 0.155 no no no no up no 18:0/18:0-PS+blood TDCA+blood 0 0 -0.430524205 yes serum_phospholipids serum_bileacids 0.00617 0.155 no up no no up no 18:0/22:6-PA+blood TDCA+blood 0 -0.573509621 0 yes serum_phospholipids serum_bileacids 0.22 0.155 no no no no up no 18:0/22:6-PC+blood TDCA+blood 0 -0.532348644 0 yes serum_phospholipids serum_bileacids 0.0775 0.155 no no up no up no 18:0/22:6-PI+blood TDCA+blood 0 -0.533720676 0 yes serum_phospholipids serum_bileacids 0.425 0.155 no no no no up no 18:1/18:0-PI+blood TDCA+blood 0 0 -0.40492739 yes serum_phospholipids serum_bileacids 0.0931 0.155 no no up no up no 18:1/18:1-PG+blood TDCA+blood 0 0 -0.495938287 yes serum_phospholipids serum_bileacids 0.00352 0.155 no up up no up no 18:1/18:2-PG+blood TDCA+blood 0 0 -0.56704055 yes serum_phospholipids serum_bileacids 5.58E-07 0.155 no up up no up no 18:1/18:2-PI+blood TDCA+blood -0.484200125 0 0 yes serum_phospholipids serum_bileacids 0.0164 0.155 dn no up no up no 18:2/20:4-PC+blood TDCA+blood -0.466413181 0 0 yes serum_phospholipids serum_bileacids 0.0145 0.155 no no up no up no 18:3n3+blood TDCA+blood -0.464436854 0 0 yes serum_fattyacid serum_bileacids 0.291 0.155 no no no no up no 20:0/20:4-PE+blood TDCA+blood 0 0.529604579 0 yes serum_phospholipids serum_bileacids 0.00128 0.155 up up no no up no 20:1/20:4-PC+blood TDCA+blood 0 -0.681900196 0 yes serum_phospholipids serum_bileacids 0.0419 0.155 no no up no up no 20:3/18:0-PC+blood TDCA+blood 0 -0.584485882 0 yes serum_phospholipids serum_bileacids 0.296 0.155 no no no no up no 20:5/18:0-PC+blood TDCA+blood -0.456531546 -0.504907992 0 yes serum_phospholipids serum_bileacids 3.97E-06 0.155 no up up no up no 3-(3-Hydroxyphenyl)propanoic acid+stool TDCA+blood 0 0 -0.474764175 yes stool_cometabolism serum_bileacids 0.33 0.155 no no no no up no 5-HETE+blood TDCA+blood 0 -0.668963416 0 yes serum_ARA serum_bileacids 0.697 0.155 no no no no up no 9-HODE+blood TDCA+blood -0.501987068 0 0 yes serum_ARA serum_bileacids 0.297 0.155 no no no no up no AA+blood TDCA+blood -0.557324225 0 0 yes serum_ARA serum_bileacids 0.212 0.155 no no no no up no AMPK signaling pathway TDCA+blood 0.599760912 0.582989891 0 yes kegg serum_bileacids NA 0.155 no no no no up no Anaerostipes TDCA+blood 0 -0.589998362 0 butyrate-producing yes Genus serum_bileacids 0.568 0.155 no no no no up no Bifidobacterium TDCA+blood -0.508107103 0 0 acetate-producing yes Genus serum_bileacids 0.105 0.155 no dn no no up no Blautia TDCA+blood 0 -0.550185067 0 acetate-producing yes Genus serum_bileacids 1.36E-05 0.155 up dn dn no up no Butyricimonas TDCA+blood -0.48025967 0 0 butyrate-producing yes Genus serum_bileacids 0.17 0.155 no no no no up no CA+blood TDCA+blood 0 0.565624115 0 yes serum_bileacids serum_bileacids 0.606 0.155 no no no no up no CDCA+stool TDCA+blood 0 0 -0.476300629 yes stool_bileacids serum_bileacids 0.663 0.155 no no no no up no Cellular senescence TDCA+blood 0 0 -0.430817291 yes kegg serum_bileacids NA 0.155 no no no no up no Chemical carcinogenesis - receptor activation TDCA+blood 0 0.50356808 0 yes kegg serum_bileacids NA 0.155 no no no no up no Chemokine signaling pathway TDCA+blood -0.491124973 0 0 yes kegg serum_bileacids NA 0.155 no no no no up no Cysteine+blood TDCA+blood -0.515821357 0 0 yes yes serum_aminoacids serum_bileacids 1.81E-07 0.155 dn up up no up no d18:1-16:0-SM+blood TDCA+blood 0 0 -0.457543065 yes serum_phospholipids serum_bileacids 0.14 0.155 no no no no up no d18:1-20:1-SM+blood TDCA+blood 0 0 -0.486694993 yes serum_phospholipids serum_bileacids 0.0992 0.155 no no no no up no DHA+blood TDCA+blood -0.462460527 0 0 yes serum_ARA serum_bileacids 0.872 0.155 no no no no up no DPA+blood TDCA+blood -0.472342162 0 0 yes serum_ARA serum_bileacids 0.519 0.155 no no no no up no Endocrine resistance TDCA+blood 0 0.650582922 0 yes kegg serum_bileacids NA 0.155 no no no no up no GABAergic synapse TDCA+blood 0 0 0.403791852 yes kegg serum_bileacids NA 0.155 no up up no up no GCA+blood TDCA+blood 0.498034414 0.532348644 0.490961129 yes yes serum_bileacids serum_bileacids 0.16 0.155 no no no no up no GDCA+blood TDCA+blood 0.743098967 0.867124595 0.705689964 yes serum_bileacids serum_bileacids 0.632 0.155 no no no no up no GLCA+blood TDCA+blood 0 0.509510171 0 yes serum_bileacids serum_bileacids 0.319 0.155 no no no no up no Glutathione metabolism TDCA+blood 0.659737003 0 0 yes kegg serum_bileacids NA 0.155 no no no no up no GnRH signaling pathway TDCA+blood 0 0.643823619 0 yes kegg serum_bileacids NA 0.155 no no no no up no "Growth hormone synthesis, secretion and action" TDCA+blood 0 0.530605292 0 yes kegg serum_bileacids NA 0.155 no no no no up no Hematopoietic cell lineage TDCA+blood 0 0 0.440355681 yes kegg serum_bileacids NA 0.155 no no no no up no Insulin resistance TDCA+blood 0 0 -0.404189285 yes kegg serum_bileacids NA 0.155 no no no no up no iso-LCA+blood TDCA+blood 0.484623378 0 0 yes serum_bileacids serum_bileacids 0.507 0.155 no no no no up no iso-LCA+stool TDCA+blood 0 0 0.523930692 yes stool_bileacids serum_bileacids 0.72 0.155 no no no no up no LCA+blood TDCA+blood 0 0 0.410585207 yes serum_bileacids serum_bileacids 0.884 0.155 no no no no up no Lipid and atherosclerosis TDCA+blood -0.458307867 0 0 yes kegg serum_bileacids NA 0.155 no no no no up no Longevity regulating pathway TDCA+blood 0.462834364 0 0 yes kegg serum_bileacids NA 0.155 no no no no up no Longevity regulating pathway - multiple species TDCA+blood 0 -0.525535815 0 yes kegg serum_bileacids NA 0.155 no no no no up no Malaria TDCA+blood 0.478677105 0 0 yes kegg serum_bileacids NA 0.155 no no no no up no nutriCA+stool TDCA+blood 0 0 -0.539295228 yes stool_bileacids serum_bileacids 0.481 0.155 no no no no up no "Parathyroid hormone synthesis, secretion and action" TDCA+blood 0 0.571161111 0 yes kegg serum_bileacids NA 0.155 no no no no up no Prevotella TDCA+blood 0.474016346 0.618432019 0 acetate-producing yes Genus serum_bileacids 0.287 0.155 no no no no up no Protein processing in endoplasmic reticulum TDCA+blood 0.471887359 0 0 yes kegg serum_bileacids NA 0.155 no no no no up no Purine metabolism TDCA+blood 0.563548932 0 0 yes kegg serum_bileacids NA 0.155 no no no no up no Salmonella infection TDCA+blood 0 -0.51539686 0 yes kegg serum_bileacids NA 0.155 no no no no up no Staphylococcus aureus infection TDCA+blood 0 0 0.419689169 yes kegg serum_bileacids NA 0.155 up no no no up no TCA+blood TDCA+blood 0 0 0.688246223 yes serum_bileacids serum_bileacids 0.339 0.155 no no no no up no Toxoplasmosis TDCA+blood 0 0 0.447509474 yes kegg serum_bileacids NA 0.155 no no no no up no UDCA+stool TDCA+blood 0 -0.654299708 -0.553123311 yes stool_bileacids serum_bileacids 0.266 0.155 no no no no up no Viral carcinogenesis TDCA+blood 0 0 -0.422868632 yes kegg serum_bileacids NA 0.155 no no no no up no Viral myocarditis TDCA+blood 0 -0.523845989 0 yes kegg serum_bileacids NA 0.155 no no no no up no Yersinia infection TDCA+blood -0.474150608 0 0 yes kegg serum_bileacids NA 0.155 no no no no up no 12-ketoDCA+stool TDCA+stool -0.60756467 -0.59900757 0 stool_bileacids stool_bileacids 0.505 0.963 no no no no no no 4-hydroxybenzoic acid+stool TDCA+stool 0 0.811516378 0.697260509 stool_cometabolism stool_bileacids 0.0536 0.963 no dn no no no no Antigen processing and presentation TDCA+stool 0 0.88396 0 kegg stool_bileacids NA 0.963 no no no no no no Bacterial invasion of epithelial cells TDCA+stool 0 0.618772 0 kegg stool_bileacids NA 0.963 no no no no no no Butyric acid+stool TDCA+stool -0.557109473 0 0 yes stool_scfa stool_bileacids 0.102 0.963 dn no no no no no Caproic acid+stool TDCA+stool 0 -0.733212166 0 stool_scfa stool_bileacids 0.882 0.963 no no no no no no CDCA+stool TDCA+stool 0 0 0.470987263 stool_bileacids stool_bileacids 0.663 0.963 no no no no no no Chemical carcinogenesis - receptor activation TDCA+stool 0 -0.604814737 0 kegg stool_bileacids NA 0.963 no no no no no no Choline metabolism in cancer TDCA+stool 0 -0.604814737 0 kegg stool_bileacids NA 0.963 no no no no no no Clostridium TDCA+stool 0 0.786464174 0 Genus stool_bileacids 0.925 0.963 no no no no no no Cocaine addiction TDCA+stool 0 -0.618772 0 kegg stool_bileacids NA 0.963 no no no no no no Cortisol synthesis and secretion TDCA+stool 0 -0.618772 0 kegg stool_bileacids NA 0.963 no no up no no no Cushing syndrome TDCA+stool 0 -0.623424421 0 kegg stool_bileacids NA 0.963 no no up no no no DCA+stool TDCA+stool 0 -0.654907955 -0.570168708 stool_bileacids stool_bileacids 0.195 0.963 no no no no no no Epstein-Barr virus infection TDCA+stool 0 0.88396 0 kegg stool_bileacids NA 0.963 no no no no no no GCA+stool TDCA+stool 0 0.701178625 0 stool_bileacids stool_bileacids 0.0809 0.963 no no no no no no GUDCA+stool TDCA+stool -0.497169988 0 0 yes stool_bileacids stool_bileacids 0.0085 0.963 no dn no no no no HDCA+stool TDCA+stool -0.504551975 0 -0.45404169 stool_bileacids stool_bileacids 0.176 0.963 no no no no no no Herpes simplex virus 1 infection TDCA+stool 0 0.874655158 0 kegg stool_bileacids NA 0.963 no no no no no no Human cytomegalovirus infection TDCA+stool 0 0.865350316 0 kegg stool_bileacids NA 0.963 no no dn no no no Human immunodeficiency virus 1 infection TDCA+stool 0 0.88396 0 kegg stool_bileacids NA 0.963 no no no no no no Human T-cell leukemia virus 1 infection TDCA+stool 0 0.88396 0 kegg stool_bileacids NA 0.963 no no no no no no iso-LCA+stool TDCA+stool 0 -0.754567861 -0.574654301 stool_bileacids stool_bileacids 0.72 0.963 no no no no no no Isobutyric acid+stool TDCA+stool 0 0 -0.473977659 stool_scfa stool_bileacids 0.408 0.963 no no no no no no Isovaleric acid+stool TDCA+stool 0 0 -0.471485663 stool_scfa stool_bileacids 0.343 0.963 no no no no no no LCA+stool TDCA+stool 0 -0.715415755 -0.518335189 stool_bileacids stool_bileacids 0.314 0.963 no no no no no no Leukocyte transendothelial migration TDCA+stool 0 0.749039789 0 kegg stool_bileacids NA 0.963 no no no no no no nutriCA+stool TDCA+stool 0 0 0.586117483 stool_bileacids stool_bileacids 0.481 0.963 no no no no no no p53 signaling pathway TDCA+stool 0 -0.735082526 0 kegg stool_bileacids NA 0.963 no no no no no no Phenylacetic acid+stool TDCA+stool 0 0 -0.572660704 stool_cometabolism stool_bileacids 0.785 0.963 no no no no no no Proteasome TDCA+stool 0 0.655991368 0 kegg stool_bileacids NA 0.963 no no no no no no Regulation of actin cytoskeleton TDCA+stool 0 0.66529621 0 kegg stool_bileacids NA 0.963 no no no no no no TCA+stool TDCA+stool 0.579329435 0.722018053 0 stool_bileacids stool_bileacids 0.458 0.963 no no no no no no Tight junction TDCA+stool 0 0.628076842 0 kegg stool_bileacids NA 0.963 no no no no no no Amino sugar and nucleotide sugar metabolism Terpenoid backbone biosynthesis 0 0.486166008 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Terpenoid backbone biosynthesis 0 0 -0.418275418 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Terpenoid backbone biosynthesis 0 0.428853755 0.4998713 kegg kegg NA NA no no no no no no Butanoate metabolism Terpenoid backbone biosynthesis 0 0.551383399 0.478507079 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Terpenoid backbone biosynthesis 0.427826087 0.596837945 0.727413127 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Terpenoid backbone biosynthesis 0.520869565 0.468379447 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Terpenoid backbone biosynthesis 0 0.508893281 0.630630631 kegg kegg NA NA no no no no no no Folate biosynthesis Terpenoid backbone biosynthesis 0 0 0.46975547 kegg kegg NA NA no no no no no no Glycerolipid metabolism Terpenoid backbone biosynthesis 0 0 0.476447876 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Terpenoid backbone biosynthesis 0 0 0.624453024 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Terpenoid backbone biosynthesis 0 0 -0.430888031 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Terpenoid backbone biosynthesis -0.490434783 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Terpenoid backbone biosynthesis 0 0 0.462290862 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Terpenoid backbone biosynthesis 0 0 0.485456885 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Terpenoid backbone biosynthesis -0.474782609 0 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Terpenoid backbone biosynthesis 0 0.707509881 0.422393822 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Terpenoid backbone biosynthesis 0.448695652 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Terpenoid backbone biosynthesis 0 0.441699605 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Terpenoid backbone biosynthesis 0 0 0.537194337 kegg kegg NA NA no no no no no no Lysine degradation Terpenoid backbone biosynthesis 0 0 0.594079794 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Terpenoid backbone biosynthesis 0 0 0.538223938 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Terpenoid backbone biosynthesis 0 0.486166008 0.556241956 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Terpenoid backbone biosynthesis 0.586956522 0.490118577 0.674646075 kegg kegg NA NA no no no no no no One carbon pool by folate Terpenoid backbone biosynthesis 0.659130435 0.616600791 0.662805663 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Terpenoid backbone biosynthesis 0.426956522 0 0.668725869 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Terpenoid backbone biosynthesis 0 0.588932806 0.547490347 kegg kegg NA NA no no no no no no Pentose phosphate pathway Terpenoid backbone biosynthesis -0.600869565 0 -0.491377091 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Terpenoid backbone biosynthesis 0.54173913 0.472332016 0 kegg kegg NA NA no no no no no no Propanoate metabolism Terpenoid backbone biosynthesis 0.425217391 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Terpenoid backbone biosynthesis 0 0.522727273 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Terpenoid backbone biosynthesis 0.549565217 0.421936759 0 kegg kegg NA NA no no no no no no Retinol metabolism Terpenoid backbone biosynthesis 0 0.557312253 0.518146718 kegg kegg NA NA no no no no no no Selenocompound metabolism Terpenoid backbone biosynthesis 0.590434783 0.612648221 0.636293436 kegg kegg NA NA no no no no no no Sphingolipid metabolism Terpenoid backbone biosynthesis -0.49826087 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Terpenoid backbone biosynthesis 0.789565217 0.685770751 0.638610039 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Terpenoid backbone biosynthesis 0 0.5 0.535907336 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Terpenoid backbone biosynthesis 0.651304348 0.736166008 0.715572716 kegg kegg NA NA no no no no no no Tryptophan metabolism Terpenoid backbone biosynthesis 0 0.602766798 0.520720721 kegg kegg NA NA no up no no no no Tyrosine metabolism Terpenoid backbone biosynthesis 0 0.484189723 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Terpenoid backbone biosynthesis 0 0.707509881 0.668983269 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Terpenoid backbone biosynthesis 0 0.654150198 0.555469755 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Terpenoid backbone biosynthesis 0.546956522 0.511857708 0.654826255 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism TGF-beta signaling pathway 0 0.46541502 0 kegg kegg NA NA no no no no no no ABC transporters TGF-beta signaling pathway -0.424347826 -0.485177866 0 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes TGF-beta signaling pathway 0.52173913 0.567193676 0.424195624 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" TGF-beta signaling pathway -0.52173913 -0.783596838 -0.44993565 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism TGF-beta signaling pathway -0.592173913 -0.727272727 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism TGF-beta signaling pathway -0.606956522 0 0 kegg kegg NA NA no no no no no no Apoptosis TGF-beta signaling pathway -0.48 -0.596837945 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism TGF-beta signaling pathway 0 0 -0.453796654 kegg kegg NA NA no no no no no no Arginine and proline metabolism TGF-beta signaling pathway -0.459130435 -0.622529644 0 kegg kegg NA NA no up no no no no Arginine biosynthesis TGF-beta signaling pathway -0.565217391 -0.738142292 -0.497297297 kegg kegg NA NA no no no no no no Autophagy - animal TGF-beta signaling pathway 0 -0.677865613 0 kegg kegg NA NA no no no no no no Autophagy - other TGF-beta signaling pathway 0 0 0.521492921 kegg kegg NA NA no no no no no no Basal transcription factors TGF-beta signaling pathway 0 0 0.629086229 kegg kegg NA NA no no no no no no beta-Alanine metabolism TGF-beta signaling pathway -0.550434783 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids TGF-beta signaling pathway -0.729565217 -0.532608696 -0.611325611 kegg kegg NA NA no no no no no no Biosynthesis of cofactors TGF-beta signaling pathway 0 0 -0.462033462 kegg kegg NA NA no no no no no no Butanoate metabolism TGF-beta signaling pathway 0 0.631422925 0 kegg kegg NA NA no no no no no no Calcium signaling pathway TGF-beta signaling pathway 0.686086957 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway TGF-beta signaling pathway 0.56173913 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism TGF-beta signaling pathway -0.605217391 0 -0.410810811 kegg kegg NA NA no no no no no no Cardiac muscle contraction TGF-beta signaling pathway 0.690434783 0.612648221 0.478249678 kegg kegg NA NA no no up no no no Cell cycle TGF-beta signaling pathway 0 0.42687747 0.657142857 kegg kegg NA NA no no no no no no Cellular senescence TGF-beta signaling pathway -0.431304348 0 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway TGF-beta signaling pathway 0 -0.494071146 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway TGF-beta signaling pathway 0 -0.453557312 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) TGF-beta signaling pathway 0 0.649209486 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism TGF-beta signaling pathway 0 0.719367589 0 kegg kegg NA NA no no no no no no DNA replication TGF-beta signaling pathway 0 0.52173913 0.404890605 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 TGF-beta signaling pathway 0 0.593873518 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes TGF-beta signaling pathway 0 0.750988142 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance TGF-beta signaling pathway 0 0.688735178 0 kegg kegg NA NA no no no no no no Endocytosis TGF-beta signaling pathway -0.505217391 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway TGF-beta signaling pathway 0 -0.457509881 0.445302445 kegg kegg NA NA no no no no no no Ether lipid metabolism TGF-beta signaling pathway 0.648695652 0.419960474 0.419305019 kegg kegg NA NA no no no no no no Fanconi anemia pathway TGF-beta signaling pathway 0 0 0.443500644 kegg kegg NA NA no no no no no no Fatty acid biosynthesis TGF-beta signaling pathway -0.477391304 -0.782608696 0 kegg kegg NA NA no no no no no no Fatty acid degradation TGF-beta signaling pathway -0.613043478 -0.653162055 0 kegg kegg NA NA no no no no no no Fatty acid elongation TGF-beta signaling pathway 0 0.429841897 0 kegg kegg NA NA no no no no no no Fatty acid metabolism TGF-beta signaling pathway -0.613043478 -0.543478261 0 kegg kegg NA NA no no no no no no Ferroptosis TGF-beta signaling pathway 0 0 -0.444015444 kegg kegg NA NA no no no no no no Folate biosynthesis TGF-beta signaling pathway 0 0.578063241 0 kegg kegg NA NA no no no no no no FoxO signaling pathway TGF-beta signaling pathway 0 -0.632411067 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism TGF-beta signaling pathway -0.72 -0.738142292 0 kegg kegg NA NA no no no no no no Galactose metabolism TGF-beta signaling pathway -0.611304348 -0.654150198 0 kegg kegg NA NA no no no no no no Glutathione metabolism TGF-beta signaling pathway 0 0.574110672 -0.416988417 kegg kegg NA NA no no no no no no Glycerolipid metabolism TGF-beta signaling pathway 0 -0.697628458 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism TGF-beta signaling pathway 0 -0.507905138 0.434749035 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" TGF-beta signaling pathway 0 0 -0.463577864 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis TGF-beta signaling pathway -0.626956522 0.599802372 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate TGF-beta signaling pathway -0.492173913 -0.802371542 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin TGF-beta signaling pathway 0 0 0.457400257 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate TGF-beta signaling pathway 0.594782609 0 0.558558559 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series TGF-beta signaling pathway 0.557391304 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism TGF-beta signaling pathway -0.576521739 -0.716403162 -0.496267696 kegg kegg NA NA no no no no no no Hedgehog signaling pathway TGF-beta signaling pathway 0.58173913 0 0.537966538 kegg kegg NA NA no no no no no no HIF-1 signaling pathway TGF-beta signaling pathway 0 0.669960474 0 kegg kegg NA NA no no no no no no Homologous recombination TGF-beta signaling pathway 0 0 0.459459459 kegg kegg NA NA no no no no no no Inositol phosphate metabolism TGF-beta signaling pathway 0 -0.457509881 0.429343629 kegg kegg NA NA no no no no no no Linoleic acid metabolism TGF-beta signaling pathway 0 0 0.471814672 kegg kegg NA NA no no no no no no Lysine degradation TGF-beta signaling pathway 0 0 0.535649936 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis TGF-beta signaling pathway 0.519130435 0 0.520720721 kegg kegg NA NA no no no no no no MAPK signaling pathway TGF-beta signaling pathway 0 -0.414031621 0.43011583 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 TGF-beta signaling pathway 0 0.60770751 0 kegg kegg NA NA no no no no no no Mismatch repair TGF-beta signaling pathway 0 0.458498024 0 kegg kegg NA NA no no no no no no Mitophagy - animal TGF-beta signaling pathway 0.44 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway TGF-beta signaling pathway 0.697391304 0.595849802 0.626254826 kegg kegg NA NA no no no no no no mTOR signaling pathway TGF-beta signaling pathway 0 0.700592885 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis TGF-beta signaling pathway 0 0.696640316 0.535392535 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway TGF-beta signaling pathway 0 -0.73715415 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism TGF-beta signaling pathway -0.473043478 -0.770750988 -0.491119691 kegg kegg NA NA no no no no no no Nitrogen metabolism TGF-beta signaling pathway -0.626956522 -0.654150198 -0.472844273 kegg kegg NA NA no no no no no no Non-homologous end-joining TGF-beta signaling pathway -0.480869565 0.463438735 0 kegg kegg NA NA no no no no no no Notch signaling pathway TGF-beta signaling pathway 0.469565217 -0.445652174 0.543629344 kegg kegg NA NA no no no no no no Nucleotide excision repair TGF-beta signaling pathway 0 0.43972332 0.431402831 kegg kegg NA NA no no no no no no Oocyte meiosis TGF-beta signaling pathway 0.633913043 0.83201581 0.719433719 kegg kegg NA NA no no no no no no Other glycan degradation TGF-beta signaling pathway -0.417391304 -0.5 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis TGF-beta signaling pathway 0 0 0.52972973 kegg kegg NA NA no no no no no no Oxidative phosphorylation TGF-beta signaling pathway 0.704347826 0.679841897 0.416988417 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis TGF-beta signaling pathway -0.409565217 -0.62055336 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions TGF-beta signaling pathway 0 0.730237154 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway TGF-beta signaling pathway -0.543478261 -0.423913043 -0.570656371 kegg kegg NA NA no no no no no no Peroxisome TGF-beta signaling pathway -0.466956522 -0.604743083 -0.599227799 kegg kegg NA NA no no no no no no Phagosome TGF-beta signaling pathway -0.569565217 0 -0.501415701 kegg kegg NA NA no no no no no no Phenylalanine metabolism TGF-beta signaling pathway 0 0.438735178 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system TGF-beta signaling pathway 0.730434783 0 0.638867439 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway TGF-beta signaling pathway 0 -0.777667984 0 kegg kegg NA NA no up up no no no Platinum drug resistance TGF-beta signaling pathway 0 0 0.431145431 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism TGF-beta signaling pathway 0 0 -0.501158301 kegg kegg NA NA no no no no no no PPAR signaling pathway TGF-beta signaling pathway -0.420869565 -0.603754941 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis TGF-beta signaling pathway 0 0.505928854 0 kegg kegg NA NA no no no no no no Propanoate metabolism TGF-beta signaling pathway 0 0.67687747 0 kegg kegg NA NA no no no no no no Proteasome TGF-beta signaling pathway 0 0.677865613 0 kegg kegg NA NA no no no no no no Protein export TGF-beta signaling pathway 0.614782609 0.887351779 0.497554698 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum TGF-beta signaling pathway 0 0.666996047 0 kegg kegg NA NA no no no no no no Purine metabolism TGF-beta signaling pathway 0 0 -0.453281853 kegg kegg NA NA no no no no no no Pyrimidine metabolism TGF-beta signaling pathway -0.44 0.444664032 0 kegg kegg NA NA no no no no no no Pyruvate metabolism TGF-beta signaling pathway 0 0.712450593 0 kegg kegg NA NA no no no no no no Ras signaling pathway TGF-beta signaling pathway 0.584347826 0.765810277 0.819047619 yes kegg kegg NA NA no up up no no no Retinol metabolism TGF-beta signaling pathway -0.439130435 0 0 kegg kegg NA NA no no no no no no Ribosome TGF-beta signaling pathway 0.669565217 0.726284585 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes TGF-beta signaling pathway 0 0 0.541312741 kegg kegg NA NA no no no no no no RNA degradation TGF-beta signaling pathway 0.768695652 0.741106719 0.637065637 kegg kegg NA NA no no no no no no RNA polymerase TGF-beta signaling pathway 0 0.509881423 0.488545689 kegg kegg NA NA no no no no no no RNA transport TGF-beta signaling pathway 0 0.654150198 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport TGF-beta signaling pathway 0 -0.544466403 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway TGF-beta signaling pathway 0 0 0.598198198 kegg kegg NA NA no no no no no no Spliceosome TGF-beta signaling pathway 0 0 0.5001287 kegg kegg NA NA no no no no no no Starch and sucrose metabolism TGF-beta signaling pathway -0.60173913 -0.744071146 0 kegg kegg NA NA no no no no no no Steroid biosynthesis TGF-beta signaling pathway 0.440869565 0.482213439 0.408751609 kegg kegg NA NA no no no no no no Sulfur metabolism TGF-beta signaling pathway 0 0 -0.625225225 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism TGF-beta signaling pathway 0 -0.612648221 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis TGF-beta signaling pathway 0 0 0.519176319 kegg kegg NA NA no no no no no no Thiamine metabolism TGF-beta signaling pathway 0 0.621541502 0 kegg kegg NA NA no no no no no no Tryptophan metabolism TGF-beta signaling pathway 0 0.500988142 0 kegg kegg NA NA no up no no no no Tyrosine metabolism TGF-beta signaling pathway 0 0.466403162 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis TGF-beta signaling pathway 0.503478261 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" TGF-beta signaling pathway 0 0.503952569 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis TGF-beta signaling pathway 0 0.619565217 0.496782497 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction TGF-beta signaling pathway 0.64 0.630434783 0 kegg kegg NA NA no no no no no no Wnt signaling pathway TGF-beta signaling pathway 0.804347826 0.672924901 0.754954955 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Th1 and Th2 cell differentiation 0 0 0.517374517 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Th1 and Th2 cell differentiation 0 -0.532608696 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Th1 and Th2 cell differentiation 0 0 -0.425997426 kegg kegg NA NA no no no no no no AMPK signaling pathway Th1 and Th2 cell differentiation 0 -0.518774704 0 kegg kegg NA NA no no no no no no Anaerostipes Th1 and Th2 cell differentiation -0.411403111 0 0 butyrate-producing Genus kegg 0.568 NA no no no no no no Apoptosis Th1 and Th2 cell differentiation 0 0.545454545 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Th1 and Th2 cell differentiation 0 0 -0.45045045 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Th1 and Th2 cell differentiation 0 -0.592885375 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Th1 and Th2 cell differentiation 0 0.590909091 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Th1 and Th2 cell differentiation 0 0.579051383 0 kegg kegg NA NA no no no no no no Cellular senescence Th1 and Th2 cell differentiation 0 0.518774704 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Th1 and Th2 cell differentiation -0.528695652 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Th1 and Th2 cell differentiation 0 0 0.484684685 kegg kegg NA NA no no no no no no Endocytosis Th1 and Th2 cell differentiation 0 0.467391304 0 kegg kegg NA NA no no no no no no Ferroptosis Th1 and Th2 cell differentiation 0 0 -0.482110682 kegg kegg NA NA no no no no no no FoxO signaling pathway Th1 and Th2 cell differentiation -0.456521739 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Th1 and Th2 cell differentiation 0 0.429841897 0.454826255 kegg kegg NA NA no no no no no no Glutathione metabolism Th1 and Th2 cell differentiation 0 -0.639328063 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Th1 and Th2 cell differentiation 0 -0.596837945 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Th1 and Th2 cell differentiation 0 0 0.545688546 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Th1 and Th2 cell differentiation 0 0.42687747 0.423680824 kegg kegg NA NA no no up no no no Hedgehog signaling pathway Th1 and Th2 cell differentiation 0 0 0.47027027 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Th1 and Th2 cell differentiation 0 0 0.485456885 kegg kegg NA NA no no no no no no Longevity regulating pathway Th1 and Th2 cell differentiation 0 0 -0.423938224 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Th1 and Th2 cell differentiation -0.643478261 0 0 kegg kegg NA NA no no no no no no Lysine degradation Th1 and Th2 cell differentiation 0 0 0.425225225 kegg kegg NA NA no no no no no no Mismatch repair Th1 and Th2 cell differentiation 0 -0.414031621 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Th1 and Th2 cell differentiation -0.533913043 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation 0 0.488142292 0 kegg kegg NA NA no no no no no no Necroptosis Th1 and Th2 cell differentiation 0 0 -0.516859717 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Th1 and Th2 cell differentiation 0 0.416996047 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Th1 and Th2 cell differentiation 0 0 -0.477220077 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Th1 and Th2 cell differentiation 0 0.537549407 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Th1 and Th2 cell differentiation 0 0.481225296 0 kegg kegg NA NA no no no no no no Other glycan degradation Th1 and Th2 cell differentiation 0 0.535573123 0.505534106 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Th1 and Th2 cell differentiation 0 0 0.534877735 kegg kegg NA NA no no no no no no Peroxisome Th1 and Th2 cell differentiation 0 0 -0.46975547 kegg kegg NA NA no no no no no no Phagosome Th1 and Th2 cell differentiation 0 0.469367589 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Th1 and Th2 cell differentiation 0 -0.490118577 0 kegg kegg NA NA no no no no no no Propanoate metabolism Th1 and Th2 cell differentiation -0.52173913 0 0 kegg kegg NA NA no no no no no no Purine metabolism Th1 and Th2 cell differentiation 0 -0.526679842 -0.442985843 kegg kegg NA NA no no no no no no Pyrimidine metabolism Th1 and Th2 cell differentiation 0 -0.443675889 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Th1 and Th2 cell differentiation -0.413043478 0 0 kegg kegg NA NA no no no no no no RNA degradation Th1 and Th2 cell differentiation 0 0 0.454826255 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Th1 and Th2 cell differentiation 0 0.436758893 0.425997426 kegg kegg NA NA no no no no no no Sulfur metabolism Th1 and Th2 cell differentiation 0 -0.536561265 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Th1 and Th2 cell differentiation 0 0.484189723 0 yes kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Th1 and Th2 cell differentiation 0 -0.42687747 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Th1 and Th2 cell differentiation 0 -0.609683794 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Th17 cell differentiation 0 0 0.455855856 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Th17 cell differentiation 0 -0.505928854 0 kegg kegg NA NA no no up no no no Aminoacyl-tRNA biosynthesis Th17 cell differentiation 0 0 0.401029601 kegg kegg NA NA no no no no no no AMPK signaling pathway Th17 cell differentiation 0 -0.435770751 0 kegg kegg NA NA no no no no no no Anaerostipes Th17 cell differentiation -0.459597298 0 0 butyrate-producing Genus kegg 0.568 NA no no no no no no Apoptosis Th17 cell differentiation 0 0.537549407 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Th17 cell differentiation 0 -0.484189723 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Th17 cell differentiation 0 0 -0.424710425 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Th17 cell differentiation 0 -0.553359684 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Th17 cell differentiation 0 0.64229249 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Th17 cell differentiation 0 0.558300395 0 kegg kegg NA NA no no no no no no Cellular senescence Th17 cell differentiation 0 0.513833992 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Th17 cell differentiation -0.459130435 0 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Th17 cell differentiation 0 0.506916996 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Th17 cell differentiation 0 0 0.41981982 kegg kegg NA NA no no no no no no Endocytosis Th17 cell differentiation 0 0.460474308 0 kegg kegg NA NA no no no no no no Ferroptosis Th17 cell differentiation 0 0 -0.484169884 kegg kegg NA NA no no no no no no Galactose metabolism Th17 cell differentiation 0 0 0.429343629 kegg kegg NA NA no no no no no no Glutathione metabolism Th17 cell differentiation 0 -0.637351779 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Th17 cell differentiation 0 -0.551383399 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Th17 cell differentiation 0 0 0.48957529 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Th17 cell differentiation 0 0 0.489317889 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Th17 cell differentiation 0 0 0.571685972 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Th17 cell differentiation -0.546086957 0 0 kegg kegg NA NA no no no no no no Lysine degradation Th17 cell differentiation 0 0 0.441698842 kegg kegg NA NA no no no no no no Mismatch repair Th17 cell differentiation 0 -0.420948617 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Th17 cell differentiation -0.473043478 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Th17 cell differentiation 0 0.479249012 0 kegg kegg NA NA no no no no no no Necroptosis Th17 cell differentiation 0 0 -0.500900901 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Th17 cell differentiation 0.434782609 0.475296443 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Th17 cell differentiation 0 0 -0.482110682 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Th17 cell differentiation 0 0.605731225 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Th17 cell differentiation 0 0.501976285 0 kegg kegg NA NA no no no no no no Other glycan degradation Th17 cell differentiation 0 0.541501976 0.492149292 kegg kegg NA NA no no no no no no Oxidative phosphorylation Th17 cell differentiation 0 -0.427865613 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Th17 cell differentiation 0 0 0.503732304 kegg kegg NA NA no no no no no no Phagosome Th17 cell differentiation 0 0.429841897 0 kegg kegg NA NA no no no no no no Platelet activation Th17 cell differentiation 0 -0.42687747 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Th17 cell differentiation 0 -0.437747036 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Th17 cell differentiation 0 0.467391304 0 kegg kegg NA NA no no no no no no Propanoate metabolism Th17 cell differentiation -0.45826087 0 0 kegg kegg NA NA no no no no no no Purine metabolism Th17 cell differentiation 0 -0.471343874 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Th17 cell differentiation 0 -0.484189723 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Th17 cell differentiation 0 0.468379447 0 kegg kegg NA NA no no no no no no RNA degradation Th17 cell differentiation 0 0 0.486743887 kegg kegg NA NA no no no no no no Sarcina Th17 cell differentiation 0 0.422326513 0 Genus kegg 0.0703 NA no no no no no no SNARE interactions in vesicular transport Th17 cell differentiation 0 0.490118577 0.4002574 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Th17 cell differentiation 0 0.422924901 0 kegg kegg NA NA no no no no no no Sulfur metabolism Th17 cell differentiation 0 -0.51284585 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Th17 cell differentiation 0.954782609 0.971343874 0.960875161 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Th17 cell differentiation 0 0.514822134 0 yes kegg kegg NA NA no no no no no no Tyrosine metabolism Th17 cell differentiation 0 -0.434782609 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Th17 cell differentiation 0 -0.647233202 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Thermogenesis -0.442608696 0 0 kegg kegg NA NA no no no no no no ABC transporters Thermogenesis -0.437391304 -0.414031621 0 kegg kegg NA NA no up up no no no Adherens junction Thermogenesis 0 0.690711462 0.564993565 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Thermogenesis 0.69826087 0.818181818 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Thermogenesis -0.635652174 -0.803359684 -0.54980695 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Thermogenesis -0.605217391 -0.770750988 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Thermogenesis -0.588695652 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Thermogenesis -0.546956522 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Thermogenesis 0 0.440711462 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Thermogenesis 0 0.808300395 0.43037323 kegg kegg NA NA no no no no no no Apoptosis Thermogenesis -0.433043478 -0.62944664 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Thermogenesis 0 -0.441699605 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Thermogenesis -0.432173913 -0.831027668 -0.585328185 kegg kegg NA NA no up no no no no Arginine biosynthesis Thermogenesis -0.649565217 -0.745059289 -0.514285714 kegg kegg NA NA no no no no no no Autophagy - animal Thermogenesis 0 -0.763833992 -0.616216216 kegg kegg NA NA no no no no no no Axon guidance Thermogenesis 0.430434783 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Thermogenesis 0 -0.677865613 0 kegg kegg NA NA no no no no no no Bacteroides Thermogenesis -0.406086957 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no beta-Alanine metabolism Thermogenesis -0.655652174 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Thermogenesis -0.815652174 -0.641304348 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Thermogenesis -0.419130435 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Thermogenesis -0.491304348 0.443675889 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Thermogenesis 0 -0.67687747 -0.435521236 kegg kegg NA NA no no no no no no Calcium signaling pathway Thermogenesis 0.713043478 0.719367589 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Thermogenesis 0.713913043 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Thermogenesis -0.711304348 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Thermogenesis 0.948695652 0.973320158 0.895752896 kegg kegg NA NA no no up no no no Cell adhesion molecules Thermogenesis -0.534782609 -0.431818182 0 kegg kegg NA NA no no no no no no Cell cycle Thermogenesis 0 0.441699605 0 kegg kegg NA NA no no no no no no Cellular senescence Thermogenesis -0.409565217 -0.45256917 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Thermogenesis 0 -0.658102767 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Thermogenesis 0 -0.479249012 0 kegg kegg NA NA no no no no no no Circadian entrainment Thermogenesis 0.411304348 0.595849802 0 kegg kegg NA NA no up up no no no Circadian rhythm Thermogenesis 0.576521739 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Thermogenesis 0 0.481225296 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Thermogenesis -0.644347826 -0.653162055 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Thermogenesis 0 0.552371542 0.459459459 kegg kegg NA NA no no no no no no DNA replication Thermogenesis 0 0.508893281 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Thermogenesis 0 0.557312253 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Thermogenesis -0.526956522 0.605731225 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Thermogenesis 0 0.735177866 0 kegg kegg NA NA no no no no no no Endocrine resistance Thermogenesis 0.434782609 0 0 kegg kegg NA NA no no no no no no Endocytosis Thermogenesis -0.496521739 -0.471343874 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Thermogenesis 0 -0.434782609 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Thermogenesis 0.749565217 0.443675889 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Thermogenesis -0.547826087 -0.815217391 -0.592020592 kegg kegg NA NA no no no no no no Fatty acid degradation Thermogenesis -0.710434783 -0.813241107 0 kegg kegg NA NA no no no no no no Fatty acid elongation Thermogenesis -0.47826087 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Thermogenesis -0.793043478 -0.790513834 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Thermogenesis 0 -0.740118577 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Thermogenesis -0.520869565 -0.637351779 0 kegg kegg NA NA no no no no no no Focal adhesion Thermogenesis 0 0.566205534 0.427284427 kegg kegg NA NA no up up no no no Folate biosynthesis Thermogenesis 0 0.464426877 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Thermogenesis 0 -0.747035573 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Thermogenesis -0.710434783 -0.617588933 -0.503474903 kegg kegg NA NA no no no no no no Galactose metabolism Thermogenesis -0.693913043 -0.753952569 0 kegg kegg NA NA no no no no no no Glutathione metabolism Thermogenesis 0 0.686758893 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Thermogenesis 0 -0.623517787 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Thermogenesis -0.607826087 0.511857708 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Thermogenesis -0.425217391 -0.780632411 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Thermogenesis 0.575652174 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Thermogenesis 0 -0.469367589 0 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Thermogenesis -0.751304348 -0.75 -0.556756757 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Thermogenesis 0.51826087 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Thermogenesis 0 0.701581028 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Thermogenesis 0 0.678853755 0.548519949 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Thermogenesis 0 -0.808300395 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Thermogenesis 0 -0.574110672 -0.465122265 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Thermogenesis 0 -0.457509881 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Thermogenesis 0 -0.778656126 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Thermogenesis 0.496521739 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Thermogenesis 0 -0.639328063 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Thermogenesis 0 0.513833992 0 kegg kegg NA NA no no no no no no Mitophagy - animal Thermogenesis 0.586086957 0.779644269 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Thermogenesis 0.708695652 0.646245059 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Thermogenesis 0 0.713438735 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Thermogenesis 0 0.621541502 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Thermogenesis -0.493913043 -0.422924901 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Thermogenesis 0 -0.509881423 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Thermogenesis -0.503478261 -0.53458498 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Thermogenesis 0 -0.786561265 -0.469498069 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Thermogenesis -0.54 -0.778656126 -0.507335907 kegg kegg NA NA no no no no no no Nitrogen metabolism Thermogenesis -0.549565217 -0.661067194 -0.521750322 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Thermogenesis -0.453913043 -0.808300395 -0.428314028 kegg kegg NA NA no no no no no no Non-homologous end-joining Thermogenesis -0.576521739 0 0 kegg kegg NA NA no no no no no no Oocyte meiosis Thermogenesis 0 0.524703557 0.402574003 kegg kegg NA NA no no no no no no Oscillospira Thermogenesis 0 -0.462450593 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Thermogenesis 0 -0.752964427 -0.485199485 kegg kegg NA NA no no no no no no Other glycan degradation Thermogenesis -0.427826087 -0.537549407 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Thermogenesis 0.966956522 0.984189723 0.94980695 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Thermogenesis -0.444347826 -0.820158103 -0.473873874 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Thermogenesis 0 0.58201581 0.456113256 kegg kegg NA NA no no no no no no Pentose phosphate pathway Thermogenesis -0.52 -0.563241107 -0.441441441 kegg kegg NA NA no no no no no no Peroxisome Thermogenesis -0.663478261 -0.751976285 0 kegg kegg NA NA no no no no no no Phagosome Thermogenesis -0.573043478 -0.437747036 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Thermogenesis 0.528695652 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Thermogenesis 0 -0.598814229 0 kegg kegg NA NA no up up no no no Platelet activation Thermogenesis 0 0.557312253 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Thermogenesis 0 -0.621541502 0 kegg kegg NA NA no no no no no no Propanoate metabolism Thermogenesis 0 0.522727273 0.424453024 kegg kegg NA NA no no no no no no Proteasome Thermogenesis 0 0.5256917 0 kegg kegg NA NA no no no no no no Protein export Thermogenesis 0.515652174 0.786561265 0.507078507 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Thermogenesis 0 0.646245059 0 kegg kegg NA NA no no no no no no Purine metabolism Thermogenesis 0 0.421936759 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Thermogenesis -0.706956522 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Thermogenesis 0 0.635375494 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Thermogenesis 0 0.437747036 0 kegg kegg NA NA no no no no no no Ras signaling pathway Thermogenesis 0 0.575098814 0 yes kegg kegg NA NA no up up no no no Renin-angiotensin system Thermogenesis 0 -0.598814229 0 kegg kegg NA NA no no no no no no Retinol metabolism Thermogenesis -0.50173913 0 0 kegg kegg NA NA no no no no no no Ribosome Thermogenesis 0.756521739 0.898221344 0.545173745 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Thermogenesis 0 -0.743083004 -0.421106821 kegg kegg NA NA no no no no no no RNA degradation Thermogenesis 0.680869565 0.700592885 0 kegg kegg NA NA no no no no no no RNA polymerase Thermogenesis 0 0.589920949 0 kegg kegg NA NA no no no no no no RNA transport Thermogenesis 0 0.628458498 0 kegg kegg NA NA no no no no no no Ruminococcus Thermogenesis 0.406956522 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Signaling pathways regulating pluripotency of stem cells Thermogenesis 0.532173913 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Thermogenesis 0 -0.722332016 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Thermogenesis -0.512173913 -0.830039526 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Thermogenesis 0 -0.495059289 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Thermogenesis 0 -0.437747036 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Thermogenesis 0.74173913 0.706521739 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Thermogenesis 0 -0.415019763 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Thermogenesis 0 -0.43083004 0 kegg kegg NA NA no no no no no no Thiamine metabolism Thermogenesis 0 0.486166008 0 kegg kegg NA NA no no no no no no Tight junction Thermogenesis 0 0.550395257 0 kegg kegg NA NA no no no no no no TNF signaling pathway Thermogenesis 0 -0.614624506 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Thermogenesis 0 -0.703557312 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Thermogenesis -0.469565217 0 0 kegg kegg NA NA no up no no no no Ubiquitin mediated proteolysis Thermogenesis 0.606956522 0.799407115 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Thermogenesis 0.74 0.858695652 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Thermogenesis 0 -0.424901186 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Thermogenesis 0.793913043 0.691699605 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Thiamine metabolism 0 -0.475296443 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Thiamine metabolism 0.425217391 -0.463438735 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Thiamine metabolism 0.535652174 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Thiamine metabolism 0 -0.432806324 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Thiamine metabolism 0 -0.455533597 0 kegg kegg NA NA no no no no no no Butanoate metabolism Thiamine metabolism 0.513913043 0.743083004 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Thiamine metabolism 0 0.683794466 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Thiamine metabolism 0.643478261 0.793478261 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Thiamine metabolism 0 0.43972332 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Thiamine metabolism 0 -0.503952569 0 kegg kegg NA NA no no no no no no Fatty acid elongation Thiamine metabolism 0 0.544466403 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Thiamine metabolism 0.405217391 -0.421936759 0 kegg kegg NA NA no no no no no no Galactose metabolism Thiamine metabolism 0 -0.542490119 0 kegg kegg NA NA no no no no no no Glutathione metabolism Thiamine metabolism 0 0.626482213 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Thiamine metabolism 0 -0.438735178 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Thiamine metabolism 0 0.588932806 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Thiamine metabolism 0 0.673913043 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Thiamine metabolism 0 -0.696640316 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Thiamine metabolism -0.48 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Thiamine metabolism 0 -0.517786561 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Thiamine metabolism 0 -0.504940711 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Thiamine metabolism 0 -0.440711462 0 kegg kegg NA NA no no no no no no Histidine metabolism Thiamine metabolism 0.408695652 0 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Thiamine metabolism 0.406956522 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Thiamine metabolism 0.445217391 0 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Thiamine metabolism 0 0.565217391 0 kegg kegg NA NA no no no no no no One carbon pool by folate Thiamine metabolism 0.445217391 0.507905138 0 kegg kegg NA NA no no no no no no Other glycan degradation Thiamine metabolism 0 -0.416996047 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Thiamine metabolism 0.460869565 0.646245059 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Thiamine metabolism 0 -0.445652174 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Thiamine metabolism 0 0.491106719 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Thiamine metabolism 0.482608696 0.540513834 0 kegg kegg NA NA no no no no no no Propanoate metabolism Thiamine metabolism 0.633043478 0.809288538 0 kegg kegg NA NA no no no no no no Purine metabolism Thiamine metabolism 0 0.480237154 0.435006435 kegg kegg NA NA no no no no no no Pyrimidine metabolism Thiamine metabolism 0.453913043 0.441699605 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Thiamine metabolism 0.58173913 0.833992095 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Thiamine metabolism 0.422608696 -0.568181818 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Thiamine metabolism 0 0.472332016 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Thiamine metabolism 0 0.51284585 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Thiamine metabolism 0.570434783 0.615612648 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Thiamine metabolism 0 -0.461462451 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Thiamine metabolism 0.448695652 0.562252964 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Thiamine metabolism 0 0.647233202 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Thiamine metabolism 0.577391304 0.539525692 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Thiamine metabolism 0.52 0.617588933 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Thiamine metabolism 0 0.505928854 0 kegg kegg NA NA no no no no no no African trypanosomiasis Thyroid cancer 0 0 -0.653539254 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Thyroid cancer 0 0 -0.446846847 kegg kegg NA NA no no no no no no Amphetamine addiction Thyroid cancer 0 0 0.473359073 kegg kegg NA NA no no no no no no AMPK signaling pathway Thyroid cancer 0 0 0.418790219 kegg kegg NA NA no no no no no no Antigen processing and presentation Thyroid cancer 0 0.455533597 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Thyroid cancer 0 0 -0.405662806 kegg kegg NA NA no no no no no no Autophagy - other Thyroid cancer 0 -0.419960474 0 kegg kegg NA NA no no no no no no Basal transcription factors Thyroid cancer -0.499130435 0 0 kegg kegg NA NA no no no no no no Bile secretion Thyroid cancer 0 0 0.440926641 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Thyroid cancer 0 -0.494071146 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Thyroid cancer 0 0.467391304 -0.489060489 kegg kegg NA NA no no no no no no ECM-receptor interaction Thyroid cancer 0 0 0.445302445 kegg kegg NA NA no up up no no no Endocrine resistance Thyroid cancer 0 0 0.436036036 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Thyroid cancer 0 0.43972332 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Thyroid cancer 0 0 0.554440154 kegg kegg NA NA no no no no no no Fat digestion and absorption Thyroid cancer 0 0 -0.55032175 yes kegg kegg NA NA no up up no no no Focal adhesion Thyroid cancer 0 0.434782609 0 kegg kegg NA NA no up up no no no Fructose and mannose metabolism Thyroid cancer 0 0 -0.642471042 kegg kegg NA NA no no no no no no Galactose metabolism Thyroid cancer 0 0 -0.475418275 kegg kegg NA NA no no no no no no Gap junction Thyroid cancer 0 0 0.438867439 kegg kegg NA NA no no no no no no Glucagon signaling pathway Thyroid cancer 0 0 0.431660232 kegg kegg NA NA no no no no no no Glutamatergic synapse Thyroid cancer 0 0 0.442985843 kegg kegg NA NA no up up no no no Glycerolipid metabolism Thyroid cancer 0 -0.442687747 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Thyroid cancer 0 -0.592885375 0 kegg kegg NA NA no no up no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Thyroid cancer 0 0 -0.507335907 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Thyroid cancer 0 0 -0.442728443 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Thyroid cancer 0 0 -0.488545689 kegg kegg NA NA no no up no no no GnRH secretion Thyroid cancer 0 -0.461462451 0 kegg kegg NA NA no up up no no no GnRH signaling pathway Thyroid cancer 0 0 0.441184041 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Thyroid cancer 0 -0.440711462 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Thyroid cancer 0 0 -0.530501931 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Thyroid cancer 0 0 0.492149292 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Thyroid cancer 0 -0.552371542 0 kegg kegg NA NA no no no no no no Long-term depression Thyroid cancer 0 0 0.41981982 kegg kegg NA NA no no no no no no Lysine degradation Thyroid cancer 0 -0.51284585 0 kegg kegg NA NA no no no no no no Lysosome Thyroid cancer 0 0 -0.463063063 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Thyroid cancer -0.439130435 0 0 kegg kegg NA NA no up no no no no Melanogenesis Thyroid cancer 0 0 0.514800515 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Thyroid cancer 0 0 -0.405148005 kegg kegg NA NA up up up no no no Nicotine addiction Thyroid cancer 0 -0.516798419 0 kegg kegg NA NA no up up no no no Notch signaling pathway Thyroid cancer 0 -0.543478261 0 kegg kegg NA NA no no no no no no Other glycan degradation Thyroid cancer 0 -0.513833992 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Thyroid cancer 0 -0.492094862 0 kegg kegg NA NA no no no no no no Pancreatic secretion Thyroid cancer 0 0 0.418018018 kegg kegg NA NA no no no no no no Parabacteroides Thyroid cancer 0 0 -0.410837249 Genus kegg 4.19E-05 NA no up up no no no Pathways in cancer Thyroid cancer 0 0 0.442471042 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Thyroid cancer 0 -0.528656126 0 kegg kegg NA NA no no no no no no Proteasome Thyroid cancer -0.52173913 0.477272727 -0.63037323 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Thyroid cancer 0 0.459486166 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Thyroid cancer 0 0 0.445817246 kegg kegg NA NA no no no no no no Renin secretion Thyroid cancer 0 0 0.555727156 kegg kegg NA NA no no no no no no Selenocompound metabolism Thyroid cancer 0 -0.438735178 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Thyroid cancer 0 -0.429841897 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Thyroid cancer 0 0 -0.467696268 kegg kegg NA NA no no no no no no Sphingolipid metabolism Thyroid cancer 0 0 -0.411840412 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Thyroid cancer 0 0 -0.528957529 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Thyroid cancer 0 0 -0.671299871 kegg kegg NA NA no up up no no no Taurine and hypotaurine metabolism Thyroid cancer 0 -0.561264822 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Thyroid cancer -0.451304348 0 0 kegg kegg NA NA no no no no no no Tight junction Thyroid cancer 0 0.464426877 0 kegg kegg NA NA no no no no no no Toxoplasmosis Thyroid cancer -0.483478261 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Thyroid cancer 0 -0.42687747 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Thyroid cancer 0.407826087 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Thyroid cancer 0 0.425889328 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Thyroid cancer 0 0 -0.457142857 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Thyroid hormone signaling pathway 0 0.453557312 0 kegg kegg NA NA no no no no no no ABC transporters Thyroid hormone signaling pathway 0 -0.416996047 0 kegg kegg NA NA no up up no no no Adherens junction Thyroid hormone signaling pathway 0.855652174 0.913043478 0.862290862 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Thyroid hormone signaling pathway 0 0.498023715 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Thyroid hormone signaling pathway 0 -0.694664032 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Thyroid hormone signaling pathway 0 -0.51284585 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Thyroid hormone signaling pathway -0.494782609 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Thyroid hormone signaling pathway -0.495652174 -0.507905138 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Thyroid hormone signaling pathway 0 -0.58201581 -0.466666667 kegg kegg NA NA no up no no no no Arginine biosynthesis Thyroid hormone signaling pathway 0 -0.650197628 0 kegg kegg NA NA no no no no no no Autophagy - animal Thyroid hormone signaling pathway -0.531304348 -0.754940711 0 kegg kegg NA NA no no no no no no Autophagy - other Thyroid hormone signaling pathway -0.731304348 -0.665019763 0 kegg kegg NA NA no no no no no no Basal transcription factors Thyroid hormone signaling pathway -0.594782609 0 0 kegg kegg NA NA no no no no no no Base excision repair Thyroid hormone signaling pathway -0.52 0 0 kegg kegg NA NA no no no no no no Bifidobacterium Thyroid hormone signaling pathway 0 0.441804227 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Biosynthesis of amino acids Thyroid hormone signaling pathway 0 -0.423913043 0 kegg kegg NA NA no no no no no no Butyricicoccus Thyroid hormone signaling pathway -0.533698579 0 0 butyrate-producing Genus kegg 0.852 NA no no no no no no C-type lectin receptor signaling pathway Thyroid hormone signaling pathway 0 -0.513833992 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Thyroid hormone signaling pathway 0 0.630434783 0 kegg kegg NA NA no up up no no no Cardiac muscle contraction Thyroid hormone signaling pathway 0 0.682806324 0.629086229 kegg kegg NA NA no no up no no no Circadian entrainment Thyroid hormone signaling pathway 0 0.56027668 0 kegg kegg NA NA no up up no no no Cytokine-cytokine receptor interaction Thyroid hormone signaling pathway 0 0 0.43011583 kegg kegg NA NA no no no no no no Dopaminergic synapse Thyroid hormone signaling pathway 0 0.520750988 0 kegg kegg NA NA no up no no no no Dorea Thyroid hormone signaling pathway -0.523478261 0 0 Genus kegg 0.00362 NA up no dn no no no Drug metabolism - cytochrome P450 Thyroid hormone signaling pathway 0 0.528656126 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Thyroid hormone signaling pathway 0 0.617588933 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Thyroid hormone signaling pathway -0.426086957 0 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Thyroid hormone signaling pathway 0 -0.621541502 0 kegg kegg NA NA no no no no no no Fatty acid degradation Thyroid hormone signaling pathway 0 -0.685770751 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Thyroid hormone signaling pathway 0 -0.692687747 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Thyroid hormone signaling pathway 0 -0.431818182 0 kegg kegg NA NA no no no no no no Focal adhesion Thyroid hormone signaling pathway 0.834782609 0.813241107 0.803088803 kegg kegg NA NA no up up no no no Folate biosynthesis Thyroid hormone signaling pathway 0 0.523715415 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Thyroid hormone signaling pathway 0 -0.68083004 0 kegg kegg NA NA no no no no no no GABAergic synapse Thyroid hormone signaling pathway 0 -0.542490119 -0.406692407 kegg kegg NA NA no up up no no no Gap junction Thyroid hormone signaling pathway 0.430434783 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Thyroid hormone signaling pathway 0 0.460474308 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Thyroid hormone signaling pathway 0 -0.460474308 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Thyroid hormone signaling pathway 0 -0.485177866 0 kegg kegg NA NA no no up no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Thyroid hormone signaling pathway 0 -0.473320158 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Thyroid hormone signaling pathway 0 0.431818182 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Thyroid hormone signaling pathway 0 0.45256917 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Thyroid hormone signaling pathway 0 -0.662055336 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Thyroid hormone signaling pathway 0 0 0.52972973 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Thyroid hormone signaling pathway -0.583478261 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Thyroid hormone signaling pathway 0.833913043 0.884387352 0.89009009 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Thyroid hormone signaling pathway 0 -0.537549407 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Thyroid hormone signaling pathway 0 0 -0.413384813 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Thyroid hormone signaling pathway 0 0.572134387 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Thyroid hormone signaling pathway 0 -0.447628458 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Thyroid hormone signaling pathway -0.51826087 0 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Thyroid hormone signaling pathway 0 -0.605731225 0 kegg kegg NA NA no no no no no no Lachnospira Thyroid hormone signaling pathway 0 0.515443554 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Leukocyte transendothelial migration Thyroid hormone signaling pathway 0.760869565 0.549407115 0.441698842 kegg kegg NA NA no no no no no no MAPK signaling pathway Thyroid hormone signaling pathway 0 -0.611660079 0 kegg kegg NA NA no no no no no no Melanogenesis Thyroid hormone signaling pathway 0.451304348 0.584980237 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Thyroid hormone signaling pathway 0 0.51284585 0 kegg kegg NA NA no no no no no no Mitophagy - animal Thyroid hormone signaling pathway 0 0 -0.439382239 kegg kegg NA NA no no no no no no mTOR signaling pathway Thyroid hormone signaling pathway -0.455652174 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Thyroid hormone signaling pathway 0 -0.651185771 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Thyroid hormone signaling pathway 0 0.515810277 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Thyroid hormone signaling pathway 0 -0.605731225 -0.447104247 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Thyroid hormone signaling pathway 0 -0.546442688 -0.413384813 kegg kegg NA NA no no no no no no Nitrogen metabolism Thyroid hormone signaling pathway 0 -0.634387352 -0.454311454 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Thyroid hormone signaling pathway 0 -0.690711462 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Thyroid hormone signaling pathway 0 -0.539525692 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Thyroid hormone signaling pathway 0.46173913 0 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Thyroid hormone signaling pathway 0 0.652173913 0.584041184 kegg kegg NA NA no no no no no no p53 signaling pathway Thyroid hormone signaling pathway -0.549565217 -0.499011858 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Thyroid hormone signaling pathway 0 -0.625494071 0 kegg kegg NA NA no no dn no no no Paraprevotella Thyroid hormone signaling pathway 0 0.433868154 0 Genus kegg 0.118 NA no no no no no no Peroxisome Thyroid hormone signaling pathway 0 -0.687747036 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Thyroid hormone signaling pathway 0.433043478 0.52173913 0.52046332 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Thyroid hormone signaling pathway -0.479130435 0 0 yes kegg kegg NA NA no up up no no no Platelet activation Thyroid hormone signaling pathway 0.82173913 0.852766798 0.684427284 kegg kegg NA NA no no no no no no Platinum drug resistance Thyroid hormone signaling pathway -0.513043478 -0.419960474 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Thyroid hormone signaling pathway 0 -0.583992095 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Thyroid hormone signaling pathway -0.435652174 0 0 kegg kegg NA NA no no no no no no Proteasome Thyroid hormone signaling pathway -0.485217391 0 0 kegg kegg NA NA no no no no no no Protein export Thyroid hormone signaling pathway -0.468695652 0.476284585 0 kegg kegg NA NA no no no no no no Purine metabolism Thyroid hormone signaling pathway 0 0 -0.489317889 kegg kegg NA NA no no no no no no Rap1 signaling pathway Thyroid hormone signaling pathway 0.833043478 0.834980237 0.654568855 kegg kegg NA NA no no no no no no Ras signaling pathway Thyroid hormone signaling pathway 0 0.53458498 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Thyroid hormone signaling pathway 0.426086957 0.431818182 0.416731017 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Thyroid hormone signaling pathway 0 0.628458498 0.453796654 kegg kegg NA NA no no up no no no Ribosome Thyroid hormone signaling pathway 0 0.482213439 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Thyroid hormone signaling pathway -0.446956522 0 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Thyroid hormone signaling pathway -0.46173913 -0.647233202 -0.463320463 kegg kegg NA NA no no no no no no RNA degradation Thyroid hormone signaling pathway 0 0.475296443 0 kegg kegg NA NA no no no no no no RNA polymerase Thyroid hormone signaling pathway -0.596521739 0 0 kegg kegg NA NA no no no no no no RNA transport Thyroid hormone signaling pathway -0.475652174 0 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Thyroid hormone signaling pathway -0.517391304 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Thyroid hormone signaling pathway 0 -0.609683794 0 kegg kegg NA NA no no no no no no Spliceosome Thyroid hormone signaling pathway -0.673913043 -0.418972332 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Thyroid hormone signaling pathway 0 -0.592885375 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Thyroid hormone signaling pathway 0 -0.65513834 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Thyroid hormone signaling pathway 0 0.421936759 0 kegg kegg NA NA no no no no no no Thermogenesis Thyroid hormone signaling pathway 0 0.647233202 0.50965251 kegg kegg NA NA no no no no no no Thiamine metabolism Thyroid hormone signaling pathway 0 0 -0.504504505 kegg kegg NA NA no no no no no no Tight junction Thyroid hormone signaling pathway 0.651304348 0.726284585 0.404375804 kegg kegg NA NA no no no no no no TNF signaling pathway Thyroid hormone signaling pathway 0 -0.433794466 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Thyroid hormone signaling pathway 0 -0.501976285 0 yes kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Thyroid hormone signaling pathway 0 0.600790514 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Thyroid hormone signaling pathway 0 0.584980237 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Thyroid hormone synthesis 0 0 -0.405920206 kegg kegg NA NA no no no no no no ABC transporters Thyroid hormone synthesis -0.44 0 0 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes Thyroid hormone synthesis 0.500869565 0.757905138 0 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Thyroid hormone synthesis -0.53826087 -0.422924901 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Thyroid hormone synthesis -0.411304348 -0.42687747 -0.478249678 kegg kegg NA NA no no no no no no AMPK signaling pathway Thyroid hormone synthesis 0.699130435 0.604743083 0.623423423 kegg kegg NA NA no no no no no no Apoptosis Thyroid hormone synthesis -0.492173913 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Thyroid hormone synthesis 0.409565217 0 0.673359073 kegg kegg NA NA no no no no no no Arginine and proline metabolism Thyroid hormone synthesis -0.673913043 0 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Thyroid hormone synthesis -0.58 0 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Thyroid hormone synthesis 0 0 -0.652509653 kegg kegg NA NA no no no no no no Autophagy - animal Thyroid hormone synthesis -0.456521739 0 -0.454826255 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Thyroid hormone synthesis -0.497391304 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Thyroid hormone synthesis 0 -0.625494071 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Thyroid hormone synthesis 0.550434783 0.422924901 0.706563707 kegg kegg NA NA no no no no no no Blautia Thyroid hormone synthesis 0 -0.445652174 0 acetate-producing Genus kegg 1.36E-05 NA up dn dn no no no C-type lectin receptor signaling pathway Thyroid hormone synthesis -0.420869565 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Thyroid hormone synthesis 0.448695652 0.774703557 0 kegg kegg NA NA no up up no no no Carbon metabolism Thyroid hormone synthesis 0 -0.606719368 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Thyroid hormone synthesis 0 0.583003953 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Thyroid hormone synthesis 0 -0.60770751 0 kegg kegg NA NA no no no no no no Cellular senescence Thyroid hormone synthesis 0 -0.419960474 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Thyroid hormone synthesis -0.593913043 -0.541501976 0 kegg kegg NA NA no no no no no no Circadian entrainment Thyroid hormone synthesis 0.559130435 0.532608696 0.751866152 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Thyroid hormone synthesis 0 0 -0.553410553 kegg kegg NA NA no no no no no no Complement and coagulation cascades Thyroid hormone synthesis 0 -0.518774704 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Thyroid hormone synthesis 0.468695652 0.758893281 0.468983269 kegg kegg NA NA no up no no no no Drug metabolism - other enzymes Thyroid hormone synthesis 0 0 -0.535907336 kegg kegg NA NA no no no no no no ECM-receptor interaction Thyroid hormone synthesis 0.445217391 0 0 kegg kegg NA NA no up up no no no Endocrine resistance Thyroid hormone synthesis 0.584347826 0.720355731 0.567567568 kegg kegg NA NA no no no no no no Endocytosis Thyroid hormone synthesis 0 -0.58201581 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Thyroid hormone synthesis 0 0 -0.425482625 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Thyroid hormone synthesis -0.622608696 -0.506916996 -0.429343629 kegg kegg NA NA no no no no no no Fatty acid degradation Thyroid hormone synthesis -0.613043478 -0.630434783 -0.545173745 kegg kegg NA NA no no no no no no Fatty acid metabolism Thyroid hormone synthesis -0.55826087 -0.660079051 -0.455598456 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Thyroid hormone synthesis 0 -0.459486166 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Thyroid hormone synthesis -0.772173913 -0.723320158 0 kegg kegg NA NA no no no no no no Ferroptosis Thyroid hormone synthesis 0.466956522 0.43083004 0.583011583 kegg kegg NA NA no no no no no no FoxO signaling pathway Thyroid hormone synthesis -0.490434783 0 0 kegg kegg NA NA no no no no no no GABAergic synapse Thyroid hormone synthesis -0.427826087 0 0 kegg kegg NA NA no up up no no no Galactose metabolism Thyroid hormone synthesis 0 -0.565217391 0 kegg kegg NA NA no no no no no no Gap junction Thyroid hormone synthesis 0.711304348 0.66798419 0.724581725 kegg kegg NA NA no no no no no no Glutamatergic synapse Thyroid hormone synthesis 0.493043478 0 0.614157014 kegg kegg NA NA no up up no no no Glutathione metabolism Thyroid hormone synthesis 0.613043478 0.633399209 0.760617761 kegg kegg NA NA no no no no no no Glycerolipid metabolism Thyroid hormone synthesis -0.513043478 0 -0.498326898 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Thyroid hormone synthesis 0 0 -0.469240669 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Thyroid hormone synthesis 0.686956522 0.494071146 0.718404118 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Thyroid hormone synthesis -0.52173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Thyroid hormone synthesis 0 0 -0.507335907 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Thyroid hormone synthesis 0 -0.519762846 -0.545431145 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Thyroid hormone synthesis -0.563478261 -0.432806324 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Thyroid hormone synthesis 0.746956522 0.787549407 0.582496782 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Thyroid hormone synthesis -0.666086957 0 -0.510682111 kegg kegg NA NA no no no no no no Histidine metabolism Thyroid hormone synthesis 0 0 -0.495495495 kegg kegg NA NA no no no no no no IL-17 signaling pathway Thyroid hormone synthesis -0.684347826 -0.53458498 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Thyroid hormone synthesis 0.673043478 0.644268775 0.45019305 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Thyroid hormone synthesis -0.414782609 0 -0.453024453 kegg kegg NA NA no no no no no no Insulin secretion Thyroid hormone synthesis 0.790434783 0.900197628 0.658172458 yes kegg kegg NA NA no up up no no no JAK-STAT signaling pathway Thyroid hormone synthesis -0.553043478 0 0 kegg kegg NA NA no no no no no no Long-term depression Thyroid hormone synthesis 0.566956522 0.710474308 0.703474903 kegg kegg NA NA no no no no no no Longevity regulating pathway Thyroid hormone synthesis 0 0 0.588416988 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Thyroid hormone synthesis 0 -0.734189723 0 kegg kegg NA NA no no no no no no Lysosome Thyroid hormone synthesis -0.515652174 -0.580039526 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Thyroid hormone synthesis -0.486086957 -0.42687747 -0.651737452 kegg kegg NA NA no no no no no no Melanogenesis Thyroid hormone synthesis 0.656521739 0.701581028 0.512226512 kegg kegg NA NA no no no no no no Mitophagy - animal Thyroid hormone synthesis 0.670434783 0.688735178 0.561132561 kegg kegg NA NA no no no no no no mRNA surveillance pathway Thyroid hormone synthesis 0 0.523715415 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Thyroid hormone synthesis 0 -0.501976285 0 kegg kegg NA NA no no no no no no Necroptosis Thyroid hormone synthesis 0.553913043 0.540513834 0.564993565 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Thyroid hormone synthesis -0.555652174 -0.682806324 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Thyroid hormone synthesis -0.606086957 -0.567193676 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Thyroid hormone synthesis -0.650434783 0 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Thyroid hormone synthesis -0.731304348 -0.442687747 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Thyroid hormone synthesis -0.442608696 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Thyroid hormone synthesis -0.824347826 -0.514822134 0 kegg kegg NA NA no no no no no no Notch signaling pathway Thyroid hormone synthesis 0 0 -0.514285714 kegg kegg NA NA no no no no no no Odoribacter Thyroid hormone synthesis 0 -0.492324442 0 butyrate-producing Genus kegg 0.798 NA no no no no no no Olfactory transduction Thyroid hormone synthesis -0.713043478 -0.557312253 0 kegg kegg NA NA no no no no no no Oscillospira Thyroid hormone synthesis 0 -0.447628458 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Thyroid hormone synthesis -0.842608696 -0.635375494 0 kegg kegg NA NA no no no no no no Other glycan degradation Thyroid hormone synthesis 0 0 -0.503217503 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Thyroid hormone synthesis 0.66173913 0.822134387 0.71969112 kegg kegg NA NA no up up no no no Oxidative phosphorylation Thyroid hormone synthesis 0 0.58201581 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Thyroid hormone synthesis -0.76173913 -0.581027668 0 kegg kegg NA NA no no dn no no no Pentose phosphate pathway Thyroid hormone synthesis -0.412173913 -0.608695652 0 kegg kegg NA NA no no no no no no Peroxisome Thyroid hormone synthesis -0.687826087 -0.668972332 0 kegg kegg NA NA no no no no no no Phagosome Thyroid hormone synthesis 0 -0.600790514 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Thyroid hormone synthesis 0.657391304 0.446640316 0.731274131 kegg kegg NA NA no no no no no no PPAR signaling pathway Thyroid hormone synthesis -0.472173913 -0.540513834 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Thyroid hormone synthesis 0 0 -0.601287001 kegg kegg NA NA no no no no no no Proteasome Thyroid hormone synthesis 0 0 -0.466666667 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Thyroid hormone synthesis 0.637391304 0.458498024 0 kegg kegg NA NA no no no no no no Purine metabolism Thyroid hormone synthesis 0.696521739 0.538537549 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Thyroid hormone synthesis -0.56173913 -0.652173913 0 kegg kegg NA NA no no no no no no Retinol metabolism Thyroid hormone synthesis 0 0 -0.458944659 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Thyroid hormone synthesis 0 0.571146245 0 kegg kegg NA NA no no up no no no Ribosome Thyroid hormone synthesis 0.479130435 0.479249012 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Thyroid hormone synthesis -0.480869565 0 0 kegg kegg NA NA no no no no no no RNA degradation Thyroid hormone synthesis 0 0.416007905 0 kegg kegg NA NA no no no no no no Ruminococcus Thyroid hormone synthesis 0.523478261 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Selenocompound metabolism Thyroid hormone synthesis 0 0 -0.432175032 kegg kegg NA NA no no no no no no Serotonergic synapse Thyroid hormone synthesis 0 0.486166008 0.621621622 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Thyroid hormone synthesis -0.435652174 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Thyroid hormone synthesis 0 0 -0.440669241 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Thyroid hormone synthesis 0 -0.47826087 -0.635778636 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Thyroid hormone synthesis -0.665217391 -0.565217391 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Thyroid hormone synthesis 0 0 -0.454568855 kegg kegg NA NA no no no no no no Sulfur metabolism Thyroid hormone synthesis 0 0 0.498841699 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Thyroid hormone synthesis -0.672173913 -0.603754941 0 kegg kegg NA NA no up up no no no Terpenoid backbone biosynthesis Thyroid hormone synthesis 0 0 -0.417245817 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Thyroid hormone synthesis 0 -0.5 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Thyroid hormone synthesis 0 -0.529644269 0 kegg kegg NA NA no no no no no no Thermogenesis Thyroid hormone synthesis 0 0.556324111 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Thyroid hormone synthesis -0.415652174 0 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Thyroid hormone synthesis 0 0 -0.453024453 kegg kegg NA NA no up no no no no Ubiquitin mediated proteolysis Thyroid hormone synthesis 0.728695652 0.699604743 0.546718147 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Thyroid hormone synthesis 0 0 -0.418018018 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Thyroid hormone synthesis 0.584347826 0.587944664 0.689060489 kegg kegg NA NA no no no no no no VEGF signaling pathway Thyroid hormone synthesis 0 0 -0.598455598 kegg kegg NA NA no no no no no no ABC transporters Tight junction 0 -0.695652174 0 kegg kegg NA NA no up up no no no Adherens junction Tight junction 0.86173913 0.883399209 0.700643501 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Tight junction 0 -0.537549407 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Tight junction 0 -0.424901186 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Tight junction 0 0.419960474 0 kegg kegg NA NA no no no no no no Apoptosis Tight junction 0.442608696 0 0.42033462 kegg kegg NA NA no no no no no no Apoptosis - multiple species Tight junction -0.662608696 -0.677865613 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Tight junction 0 0 0.594594595 kegg kegg NA NA no no no no no no Arginine and proline metabolism Tight junction 0 -0.43972332 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Tight junction 0 -0.450592885 0 kegg kegg NA NA no no no no no no Autophagy - animal Tight junction -0.742608696 -0.791501976 -0.470527671 kegg kegg NA NA no no no no no no Autophagy - other Tight junction -0.762608696 -0.786561265 -0.728957529 kegg kegg NA NA no no no no no no Basal transcription factors Tight junction -0.626086957 0 -0.444015444 kegg kegg NA NA no no no no no no Base excision repair Tight junction -0.519130435 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Tight junction 0 0.423913043 0.405405405 kegg kegg NA NA no no no no no no Bifidobacterium Tight junction 0 0.503716255 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Biosynthesis of amino acids Tight junction 0 0 0.527670528 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Tight junction 0.416521739 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Tight junction 0 0 -0.432175032 kegg kegg NA NA no up up no no no Carbon metabolism Tight junction 0.426086957 0.592885375 0.57014157 kegg kegg NA NA no no no no no no Cardiac muscle contraction Tight junction 0 0.506916996 0 kegg kegg NA NA no no up no no no Cell cycle Tight junction 0 0 -0.456370656 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Tight junction 0 0.468379447 0 kegg kegg NA NA no no no no no no Clostridium Tight junction 0 0.538948096 0 Genus kegg 0.925 NA no no no no no no Cytokine-cytokine receptor interaction Tight junction 0 0 0.508108108 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Tight junction 0 0.552371542 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Tight junction 0 0.700592885 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Tight junction -0.586086957 -0.705533597 -0.616731017 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Tight junction 0 -0.507905138 0 kegg kegg NA NA no no no no no no Fatty acid degradation Tight junction 0 -0.496047431 0 kegg kegg NA NA no no no no no no Fatty acid elongation Tight junction 0.425217391 0.462450593 0.469240669 kegg kegg NA NA no no no no no no Focal adhesion Tight junction 0.773913043 0.915019763 0.574259974 kegg kegg NA NA no up up no no no FoxO signaling pathway Tight junction -0.634782609 -0.798418972 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Tight junction 0 -0.507905138 0 kegg kegg NA NA no no no no no no Galactose metabolism Tight junction 0 -0.434782609 0 kegg kegg NA NA no no no no no no Glutathione metabolism Tight junction 0 0.416996047 0.456885457 kegg kegg NA NA no no no no no no Glycerolipid metabolism Tight junction 0 -0.722332016 -0.415701416 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Tight junction -0.409565217 -0.726284585 -0.44041184 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Tight junction 0 0.639328063 0.451994852 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Tight junction 0 -0.686758893 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Tight junction 0.637391304 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Tight junction 0 0 -0.432432432 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Tight junction 0 -0.437747036 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Tight junction 0 0 -0.60952381 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Tight junction 0 0.428853755 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Tight junction 0.80173913 0.825098814 0.523294723 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Tight junction 0 -0.438735178 0 kegg kegg NA NA no no no no no no Homologous recombination Tight junction 0 -0.584980237 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Tight junction 0 -0.721343874 0 kegg kegg NA NA no no no no no no Lachnospira Tight junction 0 0.653817663 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Longevity regulating pathway Tight junction 0 -0.4743083 0 kegg kegg NA NA no no no no no no Lysine degradation Tight junction -0.417391304 -0.555335968 -0.561647362 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Tight junction 0 0 -0.493693694 kegg kegg NA NA no no no no no no MAPK signaling pathway Tight junction 0 -0.664031621 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Tight junction 0 0.617588933 0.407207207 kegg kegg NA NA no no no no no no mRNA surveillance pathway Tight junction 0 0 -0.558043758 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Tight junction 0 -0.555335968 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Tight junction 0 0 0.426769627 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Tight junction -0.433043478 -0.684782609 -0.605405405 kegg kegg NA NA no no no no no no Nitrogen metabolism Tight junction 0 -0.438735178 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Tight junction 0 0.43083004 0 kegg kegg NA NA no no no no no no Notch signaling pathway Tight junction 0 -0.540513834 0 kegg kegg NA NA no no no no no no Oocyte meiosis Tight junction 0 0.508893281 0 kegg kegg NA NA no no no no no no Other glycan degradation Tight junction 0 -0.588932806 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Tight junction -0.466086957 -0.58201581 -0.545945946 kegg kegg NA NA no no no no no no Oxidative phosphorylation Tight junction 0 0.559288538 0 kegg kegg NA NA no no no no no no p53 signaling pathway Tight junction -0.692173913 -0.71541502 -0.485971686 kegg kegg NA NA no no no no no no Pentose phosphate pathway Tight junction 0.424347826 0 0.443243243 kegg kegg NA NA no no no no no no Phagosome Tight junction 0 0 0.516859717 kegg kegg NA NA no no no no no no Phenylalanine metabolism Tight junction 0.609565217 0.552371542 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Tight junction -0.435652174 0 -0.482368082 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Tight junction 0 -0.495059289 0 kegg kegg NA NA no up up no no no Platinum drug resistance Tight junction -0.772173913 -0.660079051 -0.414671815 kegg kegg NA NA no no no no no no Prevotella Tight junction 0 -0.420766661 0 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Tight junction 0 0.464426877 0.443500644 kegg kegg NA NA no no no no no no Proteasome Tight junction 0 0.663043478 0 kegg kegg NA NA no no no no no no Protein export Tight junction -0.410434783 0.555335968 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Tight junction 0.708695652 0.801383399 0.611325611 kegg kegg NA NA no no no no no no Ras signaling pathway Tight junction 0 0.471343874 0 yes kegg kegg NA NA no up up no no no Ribosome Tight junction 0 0.446640316 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Tight junction -0.517391304 0 -0.445302445 kegg kegg NA NA no no no no no no RNA degradation Tight junction 0 0 -0.516859717 kegg kegg NA NA no no no no no no RNA polymerase Tight junction -0.63826087 0 0 kegg kegg NA NA no no no no no no Ruminococcus Tight junction 0 0.44675719 0 Genus kegg 0.0679 NA no no dn no no no Selenocompound metabolism Tight junction -0.523478261 -0.504940711 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Tight junction 0 -0.661067194 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Tight junction 0.419130435 0 0 kegg kegg NA NA no no no no no no Spliceosome Tight junction -0.731304348 -0.695652174 -0.613384813 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Tight junction 0 -0.451581028 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Tight junction 0.408695652 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Tight junction 0.606086957 0.436758893 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Tight junction -0.472173913 -0.820158103 -0.622651223 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Tight junction 0 0.528656126 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Tight junction 0 0.470355731 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Tight junction 0 0 0.408236808 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Tight junction 0 0 -0.407207207 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Tight junction 0 0.671936759 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Tight junction 0 0 0.491377091 kegg kegg NA NA no no no no no no 12-ketoDCA+stool TLCA+stool 0 0 -0.510090409 stool_bileacids stool_bileacids 0.505 0.243 no no no no no no Acetic acid+stool TLCA+stool 0 0.647233747 0 yes stool_scfa stool_bileacids 0.0656 0.243 dn no no no no no Akkermansia TLCA+stool 0.595782718 0 0 acetate-producing Genus stool_bileacids 0.23 0.243 no no no no no no DCA+stool TLCA+stool 0 -0.63943575 0 stool_bileacids stool_bileacids 0.195 0.243 no no no no no no Faecalibacterium TLCA+stool -0.749780076 0 0 butyrate-producing Genus stool_bileacids 0.0039 0.243 no dn dn no no no GUDCA+stool TLCA+stool 0 0.611809979 0 yes stool_bileacids stool_bileacids 0.0085 0.243 no dn no no no no Intestinal immune network for IgA production TLCA+stool 0.491163304 0 0 kegg stool_bileacids NA 0.243 no no no no no no L-Tryptophan+stool TLCA+stool 0 0.600445765 0 stool_cometabolism stool_bileacids 0.557 0.243 no no no no no no LCA+stool TLCA+stool 0 0 -0.451169074 stool_bileacids stool_bileacids 0.314 0.243 no no no no no no Ruminococcus TLCA+stool 0.521601686 0 0 Genus stool_bileacids 0.0679 0.243 no no dn no no no T-¦Á-MCA+stool TLCA+stool -0.573850174 0 0 stool_bileacids stool_bileacids 0.48 0.243 no no no no no no "12,13-EPOME+blood" TMAO+blood 0 -0.494796364 0 serum_ARA serum_choline 0.901 0.00706 no no no up up no 14:0-LPC+blood TMAO+blood 0 -0.598039216 0 serum_phospholipids serum_choline 0.00689 0.00706 up up no up up no 14:0/16:0-PC+blood TMAO+blood 0 -0.487745098 0 serum_phospholipids serum_choline 0.0358 0.00706 no up no up up no 14:0/18:0-PC+blood TMAO+blood 0 -0.580882353 0 serum_phospholipids serum_choline 0.00289 0.00706 up up no up up no 14:0/18:2-PC+blood TMAO+blood -0.517293233 -0.580882353 0 serum_phospholipids serum_choline 0.102 0.00706 no up no up up no 14:0+blood TMAO+blood -0.460150376 0 0 yes serum_fattyacid serum_choline 0.00572 0.00706 up no dn up up no 16:0/14:0-PC+blood TMAO+blood 0.511278195 0 0 serum_phospholipids serum_choline 0.0206 0.00706 no up up up up no 16:0/16:0-PI+blood TMAO+blood -0.452631579 0 0 serum_phospholipids serum_choline 0.358 0.00706 no no no up up no 16:0/16:1-PC+blood TMAO+blood 0 -0.566176471 0 serum_phospholipids serum_choline 0.00283 0.00706 up up no up up no 16:0/16:1-PI+blood TMAO+blood -0.577443609 0 0 serum_phospholipids serum_choline 0.262 0.00706 no no no up up no 16:0/18:2-PI+blood TMAO+blood 0 -0.693627451 0 serum_phospholipids serum_choline 0.269 0.00706 no no no up up no 16:0/20:4-PC+blood TMAO+blood 0.753383459 0 0 serum_phospholipids serum_choline 0.0262 0.00706 no up no up up no 16:0/22:6-PE+blood TMAO+blood 0 -0.512254902 0 serum_phospholipids serum_choline 0.000934 0.00706 up up no up up no 16:1/16:0-PC+blood TMAO+blood 0 0.551470588 0 serum_phospholipids serum_choline 0.0215 0.00706 no up up up up no 18:0-LPE+blood TMAO+blood 0 0 -0.667008547 serum_phospholipids serum_choline 0.491 0.00706 no no no up up no 18:0/16:0-PC+blood TMAO+blood 0 0.519607843 0 serum_phospholipids serum_choline 9.64E-07 0.00706 up up up up up no 18:0/18:0-PE+blood TMAO+blood 0 -0.580882353 0 serum_phospholipids serum_choline 0.00896 0.00706 up up no up up no 18:0/18:1-PE+blood TMAO+blood 0 -0.637254902 0 serum_phospholipids serum_choline 0.00716 0.00706 up up no up up no 18:0/20:4-PC+blood TMAO+blood 0.673684211 0 0 serum_phospholipids serum_choline 0.454 0.00706 no no no up up no 18:0/20:5-PC+blood TMAO+blood 0 0.595588235 0 serum_phospholipids serum_choline 0.17 0.00706 no no no up up no 18:0/22:6-PI+blood TMAO+blood -0.523308271 0 0.412649573 serum_phospholipids serum_choline 0.425 0.00706 no no no up up no 18:1-LPC+blood TMAO+blood 0 0.517156863 0 serum_phospholipids serum_choline 0.179 0.00706 no no no up up no 18:1-LPE+blood TMAO+blood 0 0 -0.414700855 serum_phospholipids serum_choline 0.117 0.00706 no no no up up no 18:1/16:0-PE+blood TMAO+blood 0 -0.504901961 0 serum_phospholipids serum_choline 0.000182 0.00706 up up no up up no 18:1/16:1-PE+blood TMAO+blood 0 -0.512254902 0 serum_phospholipids serum_choline 0.000184 0.00706 up up no up up no 18:1/18:0-PE+blood TMAO+blood 0 -0.610294118 0 serum_phospholipids serum_choline 1.39E-06 0.00706 up up no up up no 18:1/18:1-PE+blood TMAO+blood 0 -0.617647059 0 serum_phospholipids serum_choline 1.03E-05 0.00706 up up no up up no 18:1/18:2-PE+blood TMAO+blood 0 -0.588235294 -0.500854701 serum_phospholipids serum_choline 0.000293 0.00706 up up no up up no 18:1/20:4-PC+blood TMAO+blood 0.470676692 0.551470588 0 serum_phospholipids serum_choline 0.582 0.00706 no no no up up no 18:1/20:4-PE+blood TMAO+blood 0 -0.492647059 0 serum_phospholipids serum_choline 0.0578 0.00706 up no no up up no 18:2/18:1-PC+blood TMAO+blood 0 -0.507352941 0 serum_phospholipids serum_choline 2.30E-05 0.00706 dn up up up up no 18:2/18:2-PC+blood TMAO+blood 0 -0.529411765 0 serum_phospholipids serum_choline 1.98E-05 0.00706 dn up up up up no 18:2/18:2-PS+blood TMAO+blood 0 -0.558823529 0 serum_phospholipids serum_choline 0.00674 0.00706 up up no up up no 18:3/16:0-PE+blood TMAO+blood 0 -0.828431373 0 serum_phospholipids serum_choline 0.00149 0.00706 up up no up up no 20:0/20:4-PE+blood TMAO+blood 0 -0.769607843 -0.505641026 serum_phospholipids serum_choline 0.00128 0.00706 up up no up up no 20:1/20:4-PC+blood TMAO+blood 0 0.507352941 0 serum_phospholipids serum_choline 0.0419 0.00706 no no up up up no 20:1/20:4-PE+blood TMAO+blood 0 -0.598039216 -0.406495726 serum_phospholipids serum_choline 0.0042 0.00706 up up no up up no 20:1+blood TMAO+blood 0 0.5 0 yes serum_fattyacid serum_choline 2.56E-05 0.00706 dn dn dn up up no 20:2/18:1-PE+blood TMAO+blood 0 -0.68627451 0 serum_phospholipids serum_choline 0.00208 0.00706 up up no up up no 20:2/18:3-PE+blood TMAO+blood 0 0 -0.567863248 serum_phospholipids serum_choline 0.0391 0.00706 up up no up up no 20:3-LPE+blood TMAO+blood 0 0 -0.532991453 serum_phospholipids serum_choline 0.084 0.00706 no up no up up no 20:3/16:0-PC+blood TMAO+blood 0.720300752 0 0 serum_phospholipids serum_choline 0.00405 0.00706 no up up up up no 20:4-LPA+blood TMAO+blood 0 0.605392157 0 serum_phospholipids serum_choline 0.398 0.00706 no no no up up no 20:4-LPC+blood TMAO+blood 0.445112782 0 0 serum_phospholipids serum_choline 0.949 0.00706 no no no up up no 20:4-LPE+blood TMAO+blood 0 0 -0.446153846 serum_phospholipids serum_choline 0.552 0.00706 no no no up up no 20:4/16:0-PE+blood TMAO+blood 0 -0.654411765 0 serum_phospholipids serum_choline 0.00529 0.00706 no up up up up no 20:4/18:0-PE+blood TMAO+blood 0 0 -0.437264957 serum_phospholipids serum_choline 0.000755 0.00706 up up no up up no 20:5-LPC+blood TMAO+blood 0 0 0.451623932 serum_phospholipids serum_choline 0.558 0.00706 no no no up up no 22:0/16:0-PE+blood TMAO+blood 0 0.492647059 0 serum_phospholipids serum_choline 0.091 0.00706 no no up up up no 22:6-LPC+blood TMAO+blood -0.472180451 0 0.591794872 serum_phospholipids serum_choline 0.127 0.00706 no no up up up no 22:6n3+blood TMAO+blood -0.482706767 0 0.546666667 serum_fattyacid serum_choline 0.792 0.00706 no no no up up no 4-hydroxybenzoic acid+stool TMAO+blood 0 0 -0.458646617 stool_cometabolism serum_choline 0.0536 0.00706 no dn no up up no 8-HETE+blood TMAO+blood 0 0.492647059 0 serum_ARA serum_choline 0.741 0.00706 no no no up up no Axon guidance TMAO+blood 0 -0.523529412 -0.433846154 kegg serum_choline NA 0.00706 no up up up up no Bacteroides TMAO+blood 0 0 0.564444444 LPS-producing Genus serum_choline 0.000267 0.00706 dn dn up up up no cGMP-PKG signaling pathway TMAO+blood 0 0 -0.429230769 kegg serum_choline NA 0.00706 no no no up up no Collinsella TMAO+blood -0.462349922 0 0 Genus serum_choline 0.128 0.00706 no no no up up no d18:1-18:0-SM+blood TMAO+blood 0 0.49754902 0 serum_phospholipids serum_choline 0.97 0.00706 no no no up up no Dopaminergic synapse TMAO+blood 0 -0.555882353 0 kegg serum_choline NA 0.00706 no up no up up no DPA+blood TMAO+blood -0.551879699 0 0 serum_ARA serum_choline 0.519 0.00706 no no no up up no EPA+blood TMAO+blood 0 0 0.466666667 serum_ARA serum_choline 0.212 0.00706 no no no up up no Gemmiger TMAO+blood 0 0 0.506507592 butyrate-producing Genus serum_choline 0.595 0.00706 no no no up up no Glycine+blood TMAO+blood 0.584962406 0 0 serum_aminoacids serum_choline 0.00408 0.00706 dn no up up up no HCA+blood TMAO+blood 0 -0.496049013 0 serum_bileacids serum_choline 0.544 0.00706 no no no up up no HDCA+blood TMAO+blood 0 0 0.543040649 serum_bileacids serum_choline 0.483 0.00706 no no no up up no heptanoic acid C7+blood TMAO+blood 0 0 0.405811966 serum_mcfa serum_choline 8.27E-11 0.00706 dn dn no up up no iso-LCA+blood TMAO+blood 0 0 0.454236336 serum_bileacids serum_choline 0.507 0.00706 no no no up up no isocapric acid iso-C6+blood TMAO+blood 0 0 -0.404444444 serum_scfa serum_choline 0.0458 0.00706 no no dn up up no L-2-Aminobutyric acid+blood TMAO+blood 0 0.514705882 0 yes serum_aminoacids serum_choline 0.000328 0.00706 up up no up up no L-Asparagine+blood TMAO+blood 0 0.5 0 serum_aminoacids serum_choline 0.784 0.00706 no no no up up no L-Aspartic acid+blood TMAO+blood 0.560902256 0 0.485128205 yes serum_aminoacids serum_choline 0.0226 0.00706 up up no up up no L-Glutamine+blood TMAO+blood 0.554887218 0.568627451 0 serum_aminoacids serum_choline 0.639 0.00706 no no no up up no L-Histidine+blood TMAO+blood 0 0.539215686 0 serum_aminoacids serum_choline 0.109 0.00706 no no no up up no L-Ornithine+blood TMAO+blood 0 0 0.491965812 serum_aminoacids serum_choline 0.175 0.00706 no no no up up no L-Phenylalanine+stool TMAO+blood 0 0 0.494736842 stool_cometabolism serum_choline 0.398 0.00706 no no no up up no L-Threonine+blood TMAO+blood 0 0.539215686 -0.442735043 serum_aminoacids serum_choline 0.0538 0.00706 dn no up up up no L-Tryptophan+stool TMAO+blood 0 0 0.535338346 stool_cometabolism serum_choline 0.557 0.00706 no no no up up no L-Tyrosine+stool TMAO+blood 0 0 0.457142857 stool_cometabolism serum_choline 0.44 0.00706 no no no up up no lauric acid C12+blood TMAO+blood 0.586466165 0 0.405128205 serum_mcfa serum_choline 0.015 0.00706 no dn dn up up no LCA+blood TMAO+blood 0 0 0.524057263 serum_bileacids serum_choline 0.884 0.00706 no no no up up no Legionellosis TMAO+blood -0.466666667 0 0 kegg serum_choline NA 0.00706 no no no up up no Measles TMAO+blood 0 0 0.413846154 kegg serum_choline NA 0.00706 no no no up up no MUFA%+blood TMAO+blood 0 0.573529412 0 serum_fattyacid serum_choline 0.00142 0.00706 up no dn up up no n3+blood TMAO+blood 0 0 0.641709402 serum_fattyacid serum_choline 0.806 0.00706 no no no up up no n6/n3+blood TMAO+blood 0.517293233 0 -0.422222222 serum_fattyacid serum_choline 0.226 0.00706 no no no up up no Phenylacetic acid+stool TMAO+blood 0 0 0.523308271 stool_cometabolism serum_choline 0.785 0.00706 no no no up up no PUFA/MUFA+blood TMAO+blood 0.44962406 0 0 serum_fattyacid serum_choline 0.00108 0.00706 dn no up up up no PUFA/UFA+blood TMAO+blood 0.478195489 0 0 serum_fattyacid serum_choline 0.000732 0.00706 dn no up up up no PUFA%+blood TMAO+blood 0.580451128 0 0 serum_fattyacid serum_choline 0.0013 0.00706 dn no up up up no Serine+blood TMAO+blood 0.642105263 0.568627451 0 serum_aminoacids serum_choline 0.942 0.00706 no no no up up no Th1 and Th2 cell differentiation TMAO+blood 0 0.555882353 0 kegg serum_choline NA 0.00706 no no no up up no Th17 cell differentiation TMAO+blood 0 0.588235294 0 kegg serum_choline NA 0.00706 no no no up up no Toxoplasmosis TMAO+blood 0 0.641176471 0 kegg serum_choline NA 0.00706 no no no up up no UDCA+stool TMAO+blood -0.604395604 0 0 stool_bileacids serum_choline 0.266 0.00706 no no no up up no 2-Oxocarboxylic acid metabolism TNF signaling pathway -0.499130435 -0.469367589 0 kegg kegg NA NA no no no no no no Adherens junction TNF signaling pathway -0.42 -0.600790514 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" TNF signaling pathway 0 0.608695652 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism TNF signaling pathway -0.437391304 0 -0.453024453 kegg kegg NA NA no no no no no no Anaerostipes TNF signaling pathway 0 0 -0.441301218 butyrate-producing Genus kegg 0.568 NA no no no no no no Apelin signaling pathway TNF signaling pathway 0 -0.650197628 0 kegg kegg NA NA no no no no no no Apoptosis TNF signaling pathway 0 0.776679842 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism TNF signaling pathway -0.54 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism TNF signaling pathway 0 0.678853755 0.402059202 kegg kegg NA NA no up no no no no Arginine biosynthesis TNF signaling pathway 0 0.583992095 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism TNF signaling pathway -0.495652174 0 0 kegg kegg NA NA no no no no no no Autophagy - animal TNF signaling pathway 0.626956522 0.839920949 0 kegg kegg NA NA no no no no no no Autophagy - other TNF signaling pathway 0.610434783 0.517786561 0 kegg kegg NA NA no no no no no no Axon guidance TNF signaling pathway 0.497391304 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway TNF signaling pathway 0.442608696 0.914031621 0.792277992 kegg kegg NA NA no no no no no no Basal transcription factors TNF signaling pathway 0 -0.443675889 0 kegg kegg NA NA no no no no no no Base excision repair TNF signaling pathway 0 0 -0.563191763 kegg kegg NA NA no no no no no no beta-Alanine metabolism TNF signaling pathway -0.66 -0.570158103 -0.685714286 kegg kegg NA NA no no no no no no Biosynthesis of cofactors TNF signaling pathway -0.433043478 -0.575098814 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids TNF signaling pathway -0.663478261 -0.609683794 -0.744401544 kegg kegg NA NA no no no no no no Butanoate metabolism TNF signaling pathway -0.590434783 -0.743083004 -0.687001287 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway TNF signaling pathway 0.773043478 0.922924901 0.802574003 kegg kegg NA NA no no no no no no cAMP signaling pathway TNF signaling pathway 0.619130435 0.716403162 0.621364221 yes kegg kegg NA NA no up up no no no Carbon metabolism TNF signaling pathway -0.509565217 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction TNF signaling pathway 0 -0.502964427 0 kegg kegg NA NA no no up no no no Cell cycle TNF signaling pathway 0 -0.5 0 kegg kegg NA NA no no no no no no Cellular senescence TNF signaling pathway 0 0.588932806 0.526640927 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway TNF signaling pathway 0 0.46541502 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway TNF signaling pathway 0.50173913 0.575098814 0.48957529 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) TNF signaling pathway -0.64173913 -0.776679842 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism TNF signaling pathway 0 -0.785573123 -0.654311454 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway TNF signaling pathway 0.587826087 0.768774704 0.74002574 kegg kegg NA NA no no no no no no DNA replication TNF signaling pathway 0 -0.755928854 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 TNF signaling pathway 0 -0.813241107 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes TNF signaling pathway -0.626086957 -0.748023715 0 kegg kegg NA NA no no no no no no ECM-receptor interaction TNF signaling pathway 0 -0.45256917 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance TNF signaling pathway 0 -0.483201581 0 kegg kegg NA NA no no no no no no Endocytosis TNF signaling pathway 0 0 0.473616474 kegg kegg NA NA no no no no no no ErbB signaling pathway TNF signaling pathway 0.627826087 0.666007905 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway TNF signaling pathway 0 0 -0.412097812 kegg kegg NA NA no no no no no no Fatty acid biosynthesis TNF signaling pathway 0 0.580039526 0 kegg kegg NA NA no no no no no no Fatty acid elongation TNF signaling pathway -0.776521739 -0.589920949 -0.766537967 kegg kegg NA NA no no no no no no Fatty acid metabolism TNF signaling pathway -0.417391304 0 -0.418275418 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway TNF signaling pathway 0 0.773715415 0.437065637 kegg kegg NA NA no no no no no no Focal adhesion TNF signaling pathway -0.428695652 -0.661067194 0 kegg kegg NA NA no up up no no no FoxO signaling pathway TNF signaling pathway 0 0.485177866 -0.418275418 kegg kegg NA NA no no no no no no Fructose and mannose metabolism TNF signaling pathway 0 0.503952569 0 kegg kegg NA NA no no no no no no Glutathione metabolism TNF signaling pathway 0 -0.626482213 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism TNF signaling pathway 0 0.418972332 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis TNF signaling pathway -0.522608696 -0.68083004 -0.548777349 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate TNF signaling pathway 0 0.82312253 0.471557272 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin TNF signaling pathway -0.492173913 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series TNF signaling pathway 0 0.567193676 0.458687259 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism TNF signaling pathway 0 0.587944664 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage TNF signaling pathway -0.515652174 -0.446640316 -0.595109395 kegg kegg NA NA no no no no no no HIF-1 signaling pathway TNF signaling pathway 0 -0.542490119 0 kegg kegg NA NA no no no no no no Hippo signaling pathway TNF signaling pathway -0.522608696 -0.627470356 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species TNF signaling pathway 0 0.583992095 0 kegg kegg NA NA no no no no no no Histidine metabolism TNF signaling pathway -0.545217391 0 -0.462805663 kegg kegg NA NA no no no no no no Homologous recombination TNF signaling pathway 0 0 -0.510939511 kegg kegg NA NA no no no no no no IL-17 signaling pathway TNF signaling pathway 0 0.458498024 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway TNF signaling pathway 0 0.709486166 0 kegg kegg NA NA no no no no no no Lachnospira TNF signaling pathway 0 -0.474425515 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Longevity regulating pathway - multiple species TNF signaling pathway -0.405217391 0 -0.607722008 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis TNF signaling pathway 0.462608696 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 TNF signaling pathway -0.469565217 -0.818181818 -0.402831403 kegg kegg NA NA no no no no no no Mismatch repair TNF signaling pathway -0.575652174 -0.798418972 -0.613899614 kegg kegg NA NA no no no no no no mRNA surveillance pathway TNF signaling pathway 0.425217391 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway TNF signaling pathway 0 -0.461462451 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis TNF signaling pathway 0 -0.603754941 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity TNF signaling pathway 0 0.469367589 0.453796654 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway TNF signaling pathway 0.46 0.919960474 0.676447876 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism TNF signaling pathway 0 0.588932806 0 kegg kegg NA NA no no no no no no Nitrogen metabolism TNF signaling pathway 0 0.566205534 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway TNF signaling pathway 0 0.806324111 0 kegg kegg NA NA no no no no no no Non-homologous end-joining TNF signaling pathway -0.656521739 -0.704545455 -0.6002574 kegg kegg NA NA no no no no no no Notch signaling pathway TNF signaling pathway 0 0.508893281 0 kegg kegg NA NA no no no no no no Nucleotide excision repair TNF signaling pathway 0 -0.749011858 -0.647104247 kegg kegg NA NA no no no no no no One carbon pool by folate TNF signaling pathway -0.446956522 -0.735177866 -0.442471042 kegg kegg NA NA no no no no no no Oocyte meiosis TNF signaling pathway 0 -0.742094862 0 kegg kegg NA NA no no no no no no Osteoclast differentiation TNF signaling pathway 0 0.683794466 0.552123552 kegg kegg NA NA no no no no no no Other glycan degradation TNF signaling pathway 0 0.507905138 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation TNF signaling pathway 0 -0.552371542 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions TNF signaling pathway -0.653043478 -0.684782609 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism TNF signaling pathway -0.690434783 -0.713438735 -0.538223938 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway TNF signaling pathway 0 0.726284585 0.428828829 kegg kegg NA NA no up up no no no Platelet activation TNF signaling pathway -0.456521739 -0.56916996 0 kegg kegg NA NA no no no no no no PPAR signaling pathway TNF signaling pathway 0 0.692687747 0.526640927 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis TNF signaling pathway -0.695652174 -0.683794466 -0.609266409 kegg kegg NA NA no no no no no no Propanoate metabolism TNF signaling pathway -0.413043478 -0.773715415 -0.657915058 kegg kegg NA NA no no no no no no Proteasome TNF signaling pathway 0 -0.690711462 0 kegg kegg NA NA no no no no no no Protein export TNF signaling pathway 0 -0.619565217 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum TNF signaling pathway 0 -0.539525692 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism TNF signaling pathway -0.555652174 -0.716403162 0 kegg kegg NA NA no no no no no no Pyruvate metabolism TNF signaling pathway -0.52 -0.805335968 -0.73976834 kegg kegg NA NA no no no no no no Ras signaling pathway TNF signaling pathway 0 -0.586956522 0 yes kegg kegg NA NA no up up no no no Retinol metabolism TNF signaling pathway -0.554782609 -0.658102767 -0.502445302 kegg kegg NA NA no no no no no no Ribosome TNF signaling pathway 0 -0.568181818 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes TNF signaling pathway 0 -0.504940711 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway TNF signaling pathway 0.772173913 0.910079051 0.756241956 kegg kegg NA NA no no no no no no RNA degradation TNF signaling pathway 0 -0.458498024 0 kegg kegg NA NA no no no no no no RNA polymerase TNF signaling pathway 0 -0.558300395 0 kegg kegg NA NA no no no no no no Sarcina TNF signaling pathway 0 0.422326513 0 Genus kegg 0.0703 NA no no no no no no Signaling pathways regulating pluripotency of stem cells TNF signaling pathway 0.590434783 0.418972332 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport TNF signaling pathway 0 0.635375494 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway TNF signaling pathway 0.515652174 0.568181818 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism TNF signaling pathway 0 0.458498024 0 kegg kegg NA NA no no no no no no Steroid biosynthesis TNF signaling pathway 0 -0.836956522 -0.616988417 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis TNF signaling pathway -0.65826087 -0.736166008 0 kegg kegg NA NA no no no no no no Sulfur metabolism TNF signaling pathway -0.486086957 -0.445652174 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies TNF signaling pathway -0.510434783 -0.734189723 -0.533333333 kegg kegg NA NA no no no no no no T cell receptor signaling pathway TNF signaling pathway 0.597391304 0.683794466 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism TNF signaling pathway 0 0.571146245 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis TNF signaling pathway 0 -0.449604743 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway TNF signaling pathway 0 -0.598814229 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation TNF signaling pathway 0 0.520750988 0 kegg kegg NA NA no no no no no no Th17 cell differentiation TNF signaling pathway 0 0.583992095 0 kegg kegg NA NA no no no no no no Thiamine metabolism TNF signaling pathway 0 -0.588932806 0 kegg kegg NA NA no no no no no no Tight junction TNF signaling pathway -0.499130435 -0.618577075 -0.435006435 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway TNF signaling pathway 0.807826087 0.881422925 0.850707851 yes kegg kegg NA NA no no no no no no Tryptophan metabolism TNF signaling pathway -0.722608696 -0.72826087 -0.495495495 kegg kegg NA NA no up no no no no Tyrosine metabolism TNF signaling pathway -0.773043478 -0.860671937 -0.765250965 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis TNF signaling pathway -0.666956522 -0.694664032 -0.518146718 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" TNF signaling pathway -0.613043478 -0.732213439 -0.714800515 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis TNF signaling pathway 0 -0.446640316 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction TNF signaling pathway 0 -0.643280632 0 kegg kegg NA NA no no no no no no VEGF signaling pathway TNF signaling pathway 0.554782609 0.674901186 0 kegg kegg NA NA no no no no no no Wnt signaling pathway TNF signaling pathway 0 -0.498023715 0 kegg kegg NA NA no no no no no no 14:0+blood TNF-a -0.745454545 0 0 yes serum_fattyacid serum_cytokines 0.00572 0.613 up no dn no no no 16:0/18:0-PS+blood TNF-a -0.709090909 0 0 serum_phospholipids serum_cytokines 0.377 0.613 no no no no no no 16:0+blood TNF-a -0.648484848 0 0 yes serum_fattyacid serum_cytokines 0.00876 0.613 up no no no no no 18:0/18:0-PS+blood TNF-a -0.854545455 0 0 serum_phospholipids serum_cytokines 0.00617 0.613 no up no no no no 18:0/22:6-PA+blood TNF-a -0.672727273 0 0 serum_phospholipids serum_cytokines 0.22 0.613 no no no no no no 18:1-LPC+blood TNF-a 0.721212121 0 0 serum_phospholipids serum_cytokines 0.179 0.613 no no no no no no 20:0+blood TNF-a 0.696969697 0 0 yes serum_fattyacid serum_cytokines 0.000278 0.613 dn no up no no no 20:1+blood TNF-a 0.76969697 0 0 yes serum_fattyacid serum_cytokines 2.56E-05 0.613 dn dn dn no no no B cell receptor signaling pathway TNF-a 0.60989011 0 0 kegg serum_cytokines NA 0.613 no no no no no no Bifidobacterium TNF-a -0.604395604 0 0 acetate-producing Genus serum_cytokines 0.105 0.613 no dn no no no no Biosynthesis of amino acids TNF-a -0.615384615 0 0 kegg serum_cytokines NA 0.613 no no no no no no Carbon metabolism TNF-a -0.615384615 0 0 kegg serum_cytokines NA 0.613 no no no no no no Choline+blood TNF-a 0.76969697 0 0 serum_choline serum_cytokines 0.0395 0.613 no up no no no no Collinsella TNF-a -0.610729601 0 0 Genus serum_cytokines 0.128 0.613 no no no no no no EPA+blood TNF-a -0.733333333 0 0 serum_ARA serum_cytokines 0.212 0.613 no no no no no no Gemmiger TNF-a -0.56043956 0 0 butyrate-producing Genus serum_cytokines 0.595 0.613 no no no no no no Glycolysis / Gluconeogenesis TNF-a -0.708791209 0 0 kegg serum_cytokines NA 0.613 no no no no no no GM-CSF TNF-a 0 0 -0.508342603 yes serum_cytokines serum_cytokines 0.0124 0.613 up no no no no no IFN-g TNF-a 0 -0.6 0 serum_cytokines serum_cytokines 0.825 0.613 no no no no no no IL-17A TNF-a 0 0 0.562625139 serum_cytokines serum_cytokines 0.855 0.613 no no no no no no IL-1ra TNF-a 0 0 -0.567964405 yes serum_cytokines serum_cytokines 0.0288 0.613 no up no no no no IL-2 TNF-a 0 -0.588311688 0 serum_cytokines serum_cytokines 0.522 0.613 no no no no no no IL-4 TNF-a 0 0 0.572858732 serum_cytokines serum_cytokines 0.858 0.613 no no no no no no IL-6 TNF-a 0 -0.471428571 0 serum_cytokines serum_cytokines 0.52 0.613 no no no no no no IL-8 TNF-a 0 0 -0.514571746 serum_cytokines serum_cytokines 0.579 0.613 no no no no no no IL-9 TNF-a 0 0.51038961 0 serum_cytokines serum_cytokines 0.906 0.613 no no no no no no Insulin resistance TNF-a 0.56043956 0 0 kegg serum_cytokines NA 0.613 no no no no no no IP-10 TNF-a 0 0.588311688 0 serum_cytokines serum_cytokines 0.394 0.613 no no no no no no L-Citrulline+blood TNF-a 0.757575758 0 0 serum_aminoacids serum_cytokines 0.534 0.613 no no no no no no L-Homocystine+blood TNF-a 0.660606061 0 0 serum_aminoacids serum_cytokines 0.197 0.613 no no no no no no Longevity regulating pathway - multiple species TNF-a -0.615384615 0 0 kegg serum_cytokines NA 0.613 no no no no no no MIP-1a TNF-a 0 0.67012987 0 serum_cytokines serum_cytokines 0.68 0.613 no no no no no no MIP-1b TNF-a 0 0.509090909 0 serum_cytokines serum_cytokines 0.632 0.613 no no no no no no mRNA surveillance pathway TNF-a 0.659340659 0 0 kegg serum_cytokines NA 0.613 no no no no no no NF-kappa B signaling pathway TNF-a 0.604395604 0 0 kegg serum_cytokines NA 0.613 no no no no no no Pathways in cancer TNF-a 0.642857143 0 0 kegg serum_cytokines NA 0.613 no no no no no no Primary immunodeficiency TNF-a -0.587912088 0 0 kegg serum_cytokines NA 0.613 no no no no no no RNA degradation TNF-a 0.593406593 0 0 kegg serum_cytokines NA 0.613 no no no no no no Roseburia TNF-a -0.675824176 0 0 butyrate-producing Genus serum_cytokines 0.495 0.613 no no no no no no Small cell lung cancer TNF-a 0.82967033 0 0 kegg serum_cytokines NA 0.613 no no up no no no Th1 and Th2 cell differentiation TNF-a 0.736263736 0 0 kegg serum_cytokines NA 0.613 no no no no no no Th17 cell differentiation TNF-a 0.747252747 0 0 kegg serum_cytokines NA 0.613 no no no no no no TXB2+blood TNF-a -0.790277207 0 0 yes serum_ARA serum_cytokines 0.0644 0.613 dn no no no no no 12-ketoDCA+blood ToFA+blood -0.453868406 0 0 serum_bileacids serum_fattyacid 0.517 0.0307 no no no up no dn 14:0/16:0-PC+blood ToFA+blood 0 0 0.484444444 serum_phospholipids serum_fattyacid 0.0358 0.0307 no up no up no dn 14:0/18:0-PC+blood ToFA+blood 0 0 0.463247863 serum_phospholipids serum_fattyacid 0.00289 0.0307 up up no up no dn 14:0/18:2-PC+blood ToFA+blood 0 0 0.40991453 serum_phospholipids serum_fattyacid 0.102 0.0307 no up no up no dn 14:0+blood ToFA+blood 0.693233083 0 0.642393162 yes serum_fattyacid serum_fattyacid 0.00572 0.0307 up no dn up no dn 16:0/16:1-PC+blood ToFA+blood 0 0 0.499487179 serum_phospholipids serum_fattyacid 0.00283 0.0307 up up no up no dn 16:0/18:1-PC+blood ToFA+blood 0 0 0.494700855 serum_phospholipids serum_fattyacid 6.15E-07 0.0307 up up up up no dn 16:0+blood ToFA+blood 0.939849624 0.894607843 0.895384615 yes serum_fattyacid serum_fattyacid 0.00876 0.0307 up no no up no dn 16:1-LPC+blood ToFA+blood 0 0 0.491282051 serum_phospholipids serum_fattyacid 0.0241 0.0307 no up no up no dn 16:1+blood ToFA+blood 0.727819549 0 0.554871795 yes serum_fattyacid serum_fattyacid 0.0186 0.0307 no no dn up no dn 18:0/16:0-PC+blood ToFA+blood 0 0 0.45025641 serum_phospholipids serum_fattyacid 9.64E-07 0.0307 up up up up no dn 18:0/20:4-PI+blood ToFA+blood 0 0.56372549 0 serum_phospholipids serum_fattyacid 0.167 0.0307 no no no up no dn 18:0+blood ToFA+blood 0.793984962 0.691176471 0.581538462 serum_fattyacid serum_fattyacid 0.344 0.0307 no no no up no dn 18:1-LPE+blood ToFA+blood 0 0 -0.407863248 serum_phospholipids serum_fattyacid 0.117 0.0307 no no no up no dn 18:1/18:0-PS+blood ToFA+blood 0 0.632352941 0 serum_phospholipids serum_fattyacid 0.193 0.0307 no no no up no dn 18:1+blood ToFA+blood 0.82406015 0.674019608 0.645128205 yes serum_fattyacid serum_fattyacid 0.00202 0.0307 up no dn up no dn 18:2-LPC+blood ToFA+blood 0 0 -0.454358974 serum_phospholipids serum_fattyacid 0.00743 0.0307 dn no up up no dn 18:2n6c+blood ToFA+blood 0.660150376 0.715686275 0.71008547 serum_fattyacid serum_fattyacid 0.15 0.0307 no no no up no dn 18:3n3+blood ToFA+blood 0.581954887 0 0 serum_fattyacid serum_fattyacid 0.291 0.0307 no no no up no dn 20:2/18:3-PE+blood ToFA+blood 0 0.610294118 0 serum_phospholipids serum_fattyacid 0.0391 0.0307 up up no up no dn 20:3/16:0-PC+blood ToFA+blood 0 0.507352941 0 serum_phospholipids serum_fattyacid 0.00405 0.0307 no up up up no dn 20:3/18:0-PC+blood ToFA+blood 0.448120301 0 0 serum_phospholipids serum_fattyacid 0.296 0.0307 no no no up no dn 20:3/18:0-PI+blood ToFA+blood 0 0.49754902 0 serum_phospholipids serum_fattyacid 0.289 0.0307 no no no up no dn 20:3n6+blood ToFA+blood 0 0 0.563076923 serum_fattyacid serum_fattyacid 0.0884 0.0307 up no no up no dn 20:4-LPA+blood ToFA+blood 0.457142857 0 0 serum_phospholipids serum_fattyacid 0.398 0.0307 no no no up no dn 20:4-LPE+blood ToFA+blood 0 0.558823529 0 serum_phospholipids serum_fattyacid 0.552 0.0307 no no no up no dn 20:4/18:0-PE+blood ToFA+blood 0 0.522058824 0 serum_phospholipids serum_fattyacid 0.000755 0.0307 up up no up no dn 20:4n6+blood ToFA+blood 0 0.595588235 0 serum_fattyacid serum_fattyacid 0.133 0.0307 no no no up no dn 22:6n3+blood ToFA+blood 0.536842105 0 0 serum_fattyacid serum_fattyacid 0.792 0.0307 no no no up no dn 24:0+blood ToFA+blood 0 0.512254902 0 serum_fattyacid serum_fattyacid 0.034 0.0307 dn no up up no dn 24:1+blood ToFA+blood 0 0.56372549 0 serum_fattyacid serum_fattyacid 0.00582 0.0307 no dn dn up no dn 3-(3-Hydroxyphenyl)propanoic acid+stool ToFA+blood 0.626373626 0 0 stool_cometabolism serum_fattyacid 0.33 0.0307 no no no up no dn AA+blood ToFA+blood 0.494736842 0 0 serum_ARA serum_fattyacid 0.212 0.0307 no no no up no dn AGE-RAGE signaling pathway in diabetic complications ToFA+blood 0.568421053 0 0 kegg serum_fattyacid NA 0.0307 no no no up no dn Arginine and proline metabolism ToFA+blood 0 0 0.496153846 kegg serum_fattyacid NA 0.0307 no up no up no dn Arrhythmogenic right ventricular cardiomyopathy ToFA+blood 0 0 -0.400769231 kegg serum_fattyacid NA 0.0307 no up up up no dn Bifidobacterium ToFA+blood 0 -0.62660956 0 acetate-producing Genus serum_fattyacid 0.105 0.0307 no dn no up no dn Biosynthesis of cofactors ToFA+blood 0 0 0.483846154 kegg serum_fattyacid NA 0.0307 no no no up no dn Cardiac muscle contraction ToFA+blood 0 0 -0.408461538 kegg serum_fattyacid NA 0.0307 no no up up no dn Central carbon metabolism in cancer ToFA+blood 0.524561404 0 0 kegg serum_fattyacid NA 0.0307 no no no up no dn Cytokine-cytokine receptor interaction ToFA+blood 0.459649123 0 0 kegg serum_fattyacid NA 0.0307 no no no up no dn DCA+blood ToFA+blood -0.467669173 0 0 serum_bileacids serum_fattyacid 0.122 0.0307 no no no up no dn Focal adhesion ToFA+blood 0 0 -0.484615385 kegg serum_fattyacid NA 0.0307 no up up up no dn FoxO signaling pathway ToFA+blood 0 0 -0.445384615 kegg serum_fattyacid NA 0.0307 no no no up no dn GCDCA+blood ToFA+blood 0 0 -0.489230769 serum_bileacids serum_fattyacid 0.31 0.0307 no no no up no dn GLCA+blood ToFA+blood 0 -0.560112034 -0.458913615 serum_bileacids serum_fattyacid 0.319 0.0307 no no no up no dn Glioma ToFA+blood 0.498245614 0 0 kegg serum_fattyacid NA 0.0307 no no no up no dn Glutathione metabolism ToFA+blood 0 0 0.421538462 kegg serum_fattyacid NA 0.0307 no no no up no dn "Glycine, serine and threonine metabolism" ToFA+blood 0 -0.641176471 0.445384615 kegg serum_fattyacid NA 0.0307 no up no up no dn HCA+blood ToFA+blood 0 0 -0.414638714 serum_bileacids serum_fattyacid 0.544 0.0307 no no no up no dn Hippo signaling pathway ToFA+blood 0 0 -0.47 kegg serum_fattyacid NA 0.0307 no no no up no dn isovaleric acid iso-C5+blood ToFA+blood 0 0.519607843 0 serum_scfa serum_fattyacid 0.117 0.0307 no no no up no dn Kaposi sarcoma-associated herpesvirus infection ToFA+blood -0.475438596 0 0 kegg serum_fattyacid NA 0.0307 no no dn up no dn L-Proline+blood ToFA+blood -0.485714286 0 -0.513162393 yes serum_aminoacids serum_fattyacid 0.00265 0.0307 up up no up no dn Lipid and atherosclerosis ToFA+blood 0.570175439 0 0 kegg serum_fattyacid NA 0.0307 no no no up no dn MUFA+blood ToFA+blood 0.82556391 0.693627451 0.654700855 serum_fattyacid serum_fattyacid 0.00175 0.0307 up no dn up no dn n6+blood ToFA+blood 0.872180451 0.916666667 0.881025641 serum_fattyacid serum_fattyacid 0.153 0.0307 no no no up no dn NOD-like receptor signaling pathway ToFA+blood 0.475438596 0 0 kegg serum_fattyacid NA 0.0307 no no no up no dn Odoribacter ToFA+blood 0 0 -0.40420076 butyrate-producing Genus serum_fattyacid 0.798 0.0307 no no no up no dn Pathways of neurodegeneration - multiple diseases ToFA+blood -0.463157895 0 0 kegg serum_fattyacid NA 0.0307 no no no up no dn Pertussis ToFA+blood 0.556140351 0 0 kegg serum_fattyacid NA 0.0307 no no dn up no dn Porphyrin and chlorophyll metabolism ToFA+blood 0 -0.644117647 0.483076923 kegg serum_fattyacid NA 0.0307 no no no up no dn Prevotella ToFA+blood 0 0.502855623 0 acetate-producing Genus serum_fattyacid 0.287 0.0307 no no no up no dn PUFA/MUFA+blood ToFA+blood -0.466165414 0 0 serum_fattyacid serum_fattyacid 0.00108 0.0307 dn no up up no dn PUFA+blood ToFA+blood 0.962406015 0.950980392 0.872136752 serum_fattyacid serum_fattyacid 0.212 0.0307 no no no up no dn Ruminococcus ToFA+blood 0 -0.50245098 0 acetate-producing Genus serum_fattyacid 0.335 0.0307 no no no up no dn Salivary secretion ToFA+blood 0 0.511764706 0 kegg serum_fattyacid NA 0.0307 no no no up no dn SFA+blood ToFA+blood 0.945864662 0.946078431 0.937777778 serum_fattyacid serum_fattyacid 0.0386 0.0307 up no no up no dn Shigellosis ToFA+blood -0.61754386 0 0 kegg serum_fattyacid NA 0.0307 no no no up no dn Sphingolipid signaling pathway ToFA+blood 0 0 -0.534615385 kegg serum_fattyacid NA 0.0307 no no no up no dn T-a-MCA+blood ToFA+blood 0 0 0.453985683 serum_bileacids serum_fattyacid 0.478 0.0307 no no no up no dn Ubiquitin mediated proteolysis ToFA+blood -0.473684211 0 0 kegg serum_fattyacid NA 0.0307 no no no up no dn 2-Oxocarboxylic acid metabolism Toll-like receptor signaling pathway -0.410434783 -0.651185771 0 yes kegg kegg NA NA no no no no no no Adherens junction Toll-like receptor signaling pathway 0 -0.533596838 0 yes kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Toll-like receptor signaling pathway 0 -0.572134387 0 yes kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Toll-like receptor signaling pathway 0.436521739 0.780632411 0 yes kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Toll-like receptor signaling pathway 0 0.434782609 0 yes kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Toll-like receptor signaling pathway 0 0 -0.483912484 yes kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Toll-like receptor signaling pathway 0 -0.564229249 -0.555212355 yes kegg kegg NA NA no no no no no no Antifolate resistance Toll-like receptor signaling pathway 0 -0.540513834 0 yes kegg kegg NA NA no no no no no no Apelin signaling pathway Toll-like receptor signaling pathway 0 -0.684782609 0 yes kegg kegg NA NA no no no no no no Apoptosis Toll-like receptor signaling pathway 0 0.890316206 0.562162162 yes kegg kegg NA NA no no no no no no Apoptosis - multiple species Toll-like receptor signaling pathway 0 0 -0.569111969 yes kegg kegg NA NA no no no no no no Arachidonic acid metabolism Toll-like receptor signaling pathway -0.53826087 0 0 yes kegg kegg NA NA no no no no no no Arginine and proline metabolism Toll-like receptor signaling pathway 0 0.831027668 0.495495495 yes kegg kegg NA NA no up no no no no Arginine biosynthesis Toll-like receptor signaling pathway 0.405217391 0.780632411 0 yes kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Toll-like receptor signaling pathway 0 -0.443675889 0 yes kegg kegg NA NA no no no no no no Autophagy - animal Toll-like receptor signaling pathway 0.682608696 0.807312253 0 yes kegg kegg NA NA no no no no no no Autophagy - other Toll-like receptor signaling pathway 0.430434783 0 0 yes kegg kegg NA NA no no no no no no Basal transcription factors Toll-like receptor signaling pathway 0 -0.637351779 -0.562419562 yes kegg kegg NA NA no no no no no no Base excision repair Toll-like receptor signaling pathway 0 -0.557312253 -0.77039897 yes kegg kegg NA NA no no no no no no beta-Alanine metabolism Toll-like receptor signaling pathway 0 0 -0.553153153 yes kegg kegg NA NA no no no no no no Biosynthesis of amino acids Toll-like receptor signaling pathway 0 0.668972332 0 yes kegg kegg NA NA no no no no no no Biosynthesis of cofactors Toll-like receptor signaling pathway -0.648695652 -0.675889328 0 yes kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Toll-like receptor signaling pathway -0.454782609 -0.422924901 -0.595624196 yes kegg kegg NA NA no no no no no no Butanoate metabolism Toll-like receptor signaling pathway -0.528695652 -0.785573123 -0.686743887 yes kegg kegg NA NA no no no no no no cAMP signaling pathway Toll-like receptor signaling pathway 0 0.624505929 0.541055341 yes yes kegg kegg NA NA no up up no no no Cardiac muscle contraction Toll-like receptor signaling pathway 0 -0.615612648 0 yes kegg kegg NA NA no no up no no no Cell adhesion molecules Toll-like receptor signaling pathway 0 0.535573123 0.463835264 yes kegg kegg NA NA no no no no no no Cell cycle Toll-like receptor signaling pathway 0 -0.772727273 -0.517631918 yes kegg kegg NA NA no no no no no no Cellular senescence Toll-like receptor signaling pathway 0 0.659090909 0.601029601 yes kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Toll-like receptor signaling pathway 0.453913043 0.769762846 0.567824968 yes kegg kegg NA NA no no no no no no Chemokine signaling pathway Toll-like receptor signaling pathway 0.625217391 0.731225296 0.684427284 yes kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Toll-like receptor signaling pathway -0.6 -0.801383399 -0.45971686 yes kegg kegg NA NA no no no no no no Clostridium Toll-like receptor signaling pathway -0.404870634 0 0 yes Genus kegg 0.925 NA no no no no no no Complement and coagulation cascades Toll-like receptor signaling pathway 0 0.623517787 0 yes kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Toll-like receptor signaling pathway -0.447826087 -0.760869565 -0.741827542 yes kegg kegg NA NA no no no no no no DNA replication Toll-like receptor signaling pathway -0.430434783 -0.886363636 -0.611068211 yes kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Toll-like receptor signaling pathway 0 -0.84486166 0 yes kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Toll-like receptor signaling pathway -0.459130435 -0.776679842 0 yes kegg kegg NA NA no no no no no no ECM-receptor interaction Toll-like receptor signaling pathway 0 -0.513833992 0 yes kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Toll-like receptor signaling pathway 0 -0.528656126 0 yes kegg kegg NA NA no no no no no no Endocytosis Toll-like receptor signaling pathway 0 0.563241107 0.622393822 yes kegg kegg NA NA no no no no no no ErbB signaling pathway Toll-like receptor signaling pathway 0.533043478 0.448616601 0 yes kegg kegg NA NA no no no no no no Ether lipid metabolism Toll-like receptor signaling pathway 0 -0.599802372 -0.549034749 yes kegg kegg NA NA no no no no no no Fanconi anemia pathway Toll-like receptor signaling pathway 0 -0.517786561 -0.672844273 yes kegg kegg NA NA no no no no no no Fatty acid biosynthesis Toll-like receptor signaling pathway 0.432173913 0.782608696 0 yes kegg kegg NA NA no no no no no no Fatty acid degradation Toll-like receptor signaling pathway 0 0.501976285 0 yes kegg kegg NA NA no no no no no no Fatty acid elongation Toll-like receptor signaling pathway -0.451304348 0 -0.56036036 yes kegg kegg NA NA no no no no no no Fatty acid metabolism Toll-like receptor signaling pathway 0 0.447628458 0 yes kegg kegg NA NA no no no no no no Focal adhesion Toll-like receptor signaling pathway 0 -0.558300395 0 yes kegg kegg NA NA no up up no no no Folate biosynthesis Toll-like receptor signaling pathway 0 -0.468379447 0 yes kegg kegg NA NA no no no no no no FoxO signaling pathway Toll-like receptor signaling pathway 0 0.429841897 -0.478249678 yes kegg kegg NA NA no no no no no no Fructose and mannose metabolism Toll-like receptor signaling pathway 0 0.425889328 0 yes kegg kegg NA NA no no no no no no Galactose metabolism Toll-like receptor signaling pathway 0 0.455533597 0 yes kegg kegg NA NA no no no no no no Glutathione metabolism Toll-like receptor signaling pathway -0.504347826 -0.671936759 0 yes kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Toll-like receptor signaling pathway -0.569565217 -0.497035573 0 yes kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Toll-like receptor signaling pathway 0 -0.523715415 0 yes kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Toll-like receptor signaling pathway 0.594782609 0.755928854 0.454311454 yes kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Toll-like receptor signaling pathway -0.474782609 -0.510869565 0 yes kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Toll-like receptor signaling pathway 0 0.467391304 0 yes kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Toll-like receptor signaling pathway -0.427826087 -0.563241107 -0.46975547 yes kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Toll-like receptor signaling pathway 0 0.806324111 0 yes kegg kegg NA NA no no no no no no Hedgehog signaling pathway Toll-like receptor signaling pathway 0 -0.542490119 0 yes kegg kegg NA NA no no no no no no HIF-1 signaling pathway Toll-like receptor signaling pathway 0 -0.5 0 yes kegg kegg NA NA no no no no no no Hippo signaling pathway Toll-like receptor signaling pathway -0.531304348 -0.644268775 0 yes kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Toll-like receptor signaling pathway 0 0.638339921 0 yes kegg kegg NA NA no no no no no no Homologous recombination Toll-like receptor signaling pathway 0 0 -0.742857143 yes kegg kegg NA NA no no no no no no Inositol phosphate metabolism Toll-like receptor signaling pathway 0 0 -0.43011583 yes kegg kegg NA NA no no no no no no Linoleic acid metabolism Toll-like receptor signaling pathway 0 -0.433794466 0 yes kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Toll-like receptor signaling pathway 0 0 -0.431402831 yes kegg kegg NA NA no no no no no no Lysosome Toll-like receptor signaling pathway 0 0.599802372 0.473616474 yes kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Toll-like receptor signaling pathway 0 -0.801383399 0 yes kegg kegg NA NA no no no no no no Mismatch repair Toll-like receptor signaling pathway -0.496521739 -0.793478261 -0.712483912 yes kegg kegg NA NA no no no no no no mRNA surveillance pathway Toll-like receptor signaling pathway 0 -0.611660079 0 yes kegg kegg NA NA no no no no no no mTOR signaling pathway Toll-like receptor signaling pathway 0 -0.509881423 0 yes kegg kegg NA NA no no no no no no N-Glycan biosynthesis Toll-like receptor signaling pathway -0.424347826 -0.836956522 -0.474388674 yes kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Toll-like receptor signaling pathway 0 0.479249012 0.43037323 yes kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Toll-like receptor signaling pathway 0 0.596837945 0 yes kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Toll-like receptor signaling pathway 0.525217391 0.860671937 0.577606178 yes kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Toll-like receptor signaling pathway 0 0.815217391 0.517374517 yes kegg kegg NA NA no no no no no no Nitrogen metabolism Toll-like receptor signaling pathway 0.470434783 0.741106719 0 yes kegg kegg NA NA no no no no no no Non-homologous end-joining Toll-like receptor signaling pathway -0.475652174 -0.52173913 -0.517631918 yes kegg kegg NA NA no no no no no no Nucleotide excision repair Toll-like receptor signaling pathway -0.475652174 -0.856719368 -0.836293436 yes kegg kegg NA NA no no no no no no One carbon pool by folate Toll-like receptor signaling pathway -0.539130435 -0.860671937 -0.65971686 yes kegg kegg NA NA no no no no no no Oocyte meiosis Toll-like receptor signaling pathway 0 -0.698616601 -0.427284427 yes kegg kegg NA NA no no no no no no Osteoclast differentiation Toll-like receptor signaling pathway 0.517391304 0.87944664 0.796138996 yes kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Toll-like receptor signaling pathway 0 0 -0.464864865 yes kegg kegg NA NA no no no no no no Oxidative phosphorylation Toll-like receptor signaling pathway 0 -0.637351779 0 yes kegg kegg NA NA no no no no no no p53 signaling pathway Toll-like receptor signaling pathway 0 0 -0.554182754 yes kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Toll-like receptor signaling pathway 0 0.678853755 0 yes kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Toll-like receptor signaling pathway -0.66173913 -0.830039526 0 yes kegg kegg NA NA no no no no no no Pentose phosphate pathway Toll-like receptor signaling pathway 0 0.638339921 0 yes kegg kegg NA NA no no no no no no Peroxisome Toll-like receptor signaling pathway 0 0.601778656 0 yes kegg kegg NA NA no no no no no no Phagosome Toll-like receptor signaling pathway 0 0.559288538 0.505534106 yes kegg kegg NA NA no no no no no no Phenylalanine metabolism Toll-like receptor signaling pathway -0.632173913 -0.712450593 0 yes kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Toll-like receptor signaling pathway 0 -0.497035573 0 yes kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Toll-like receptor signaling pathway 0.506086957 0.698616601 0.481338481 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Toll-like receptor signaling pathway 0 0 -0.43989704 yes yes kegg kegg NA NA no up up no no no Platelet activation Toll-like receptor signaling pathway 0 -0.455533597 0 yes kegg kegg NA NA no no no no no no Platinum drug resistance Toll-like receptor signaling pathway 0 0 -0.594079794 yes kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Toll-like receptor signaling pathway -0.472173913 -0.442687747 0 yes kegg kegg NA NA no no no no no no PPAR signaling pathway Toll-like receptor signaling pathway 0.513913043 0.85770751 0.808236808 yes kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Toll-like receptor signaling pathway -0.57826087 -0.48715415 0 yes kegg kegg NA NA no no no no no no Propanoate metabolism Toll-like receptor signaling pathway 0 -0.703557312 -0.696525097 yes kegg kegg NA NA no no no no no no Proteasome Toll-like receptor signaling pathway 0 -0.611660079 0 yes kegg kegg NA NA no no no no no no Protein export Toll-like receptor signaling pathway 0 -0.708498024 0 yes kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Toll-like receptor signaling pathway -0.411304348 -0.795454545 -0.414157014 yes kegg kegg NA NA no no no no no no Purine metabolism Toll-like receptor signaling pathway 0 -0.499011858 0 yes kegg kegg NA NA no no no no no no Pyrimidine metabolism Toll-like receptor signaling pathway 0 -0.836956522 0 yes kegg kegg NA NA no no no no no no Pyruvate metabolism Toll-like receptor signaling pathway -0.5 -0.807312253 -0.774259974 yes kegg kegg NA NA no no no no no no Ras signaling pathway Toll-like receptor signaling pathway 0 -0.764822134 0 yes yes kegg kegg NA NA no up up no no no Renin-angiotensin system Toll-like receptor signaling pathway 0 0.673913043 0 yes kegg kegg NA NA no no no no no no Retinol metabolism Toll-like receptor signaling pathway 0 -0.690711462 -0.605405405 yes kegg kegg NA NA no no no no no no Ribosome Toll-like receptor signaling pathway 0 -0.597826087 0 yes kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Toll-like receptor signaling pathway 0 -0.727272727 -0.578378378 yes kegg kegg NA NA no no no no no no RNA degradation Toll-like receptor signaling pathway 0 -0.727272727 0 yes kegg kegg NA NA no no no no no no RNA polymerase Toll-like receptor signaling pathway 0 -0.798418972 -0.597425997 yes kegg kegg NA NA no no no no no no RNA transport Toll-like receptor signaling pathway 0 -0.449604743 0 yes kegg kegg NA NA no no no no no no Sarcina Toll-like receptor signaling pathway 0 0.444554224 0 yes Genus kegg 0.0703 NA no no no no no no Selenocompound metabolism Toll-like receptor signaling pathway 0 0 -0.591248391 yes kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Toll-like receptor signaling pathway 0 0.489130435 0 yes kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Toll-like receptor signaling pathway 0.547826087 0.621541502 0 yes kegg kegg NA NA no no no no no no Spliceosome Toll-like receptor signaling pathway 0 0 -0.402831403 yes kegg kegg NA NA no no no no no no Starch and sucrose metabolism Toll-like receptor signaling pathway 0 0.664031621 0 yes kegg kegg NA NA no no no no no no Steroid biosynthesis Toll-like receptor signaling pathway -0.473913043 -0.739130435 -0.727927928 yes kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Toll-like receptor signaling pathway -0.439130435 -0.660079051 0 yes kegg kegg NA NA no no no no no no Sulfur metabolism Toll-like receptor signaling pathway -0.503478261 -0.420948617 0 yes kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Toll-like receptor signaling pathway -0.514782609 -0.785573123 -0.661003861 yes kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Toll-like receptor signaling pathway 0 -0.513833992 -0.414671815 yes kegg kegg NA NA no no no no no no TGF-beta signaling pathway Toll-like receptor signaling pathway 0 -0.677865613 0 yes kegg kegg NA NA no no no no no no Thiamine metabolism Toll-like receptor signaling pathway 0 -0.57312253 0 yes kegg kegg NA NA no no no no no no Tight junction Toll-like receptor signaling pathway -0.462608696 -0.449604743 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Toll-like receptor signaling pathway -0.557391304 -0.602766798 -0.484427284 yes kegg kegg NA NA no up no no no no Tyrosine metabolism Toll-like receptor signaling pathway -0.615652174 -0.822134387 -0.691377091 yes kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Toll-like receptor signaling pathway -0.655652174 -0.73715415 -0.694980695 yes kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Toll-like receptor signaling pathway 0 -0.514822134 0 yes kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Toll-like receptor signaling pathway -0.587826087 -0.785573123 -0.717631918 yes kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Toll-like receptor signaling pathway 0 -0.695652174 0 yes kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Toll-like receptor signaling pathway 0 -0.635375494 0 yes kegg kegg NA NA no no no no no no VEGF signaling pathway Toll-like receptor signaling pathway 0.562608696 0.608695652 0 yes kegg kegg NA NA no no no no no no Wnt signaling pathway Toll-like receptor signaling pathway 0 -0.799407115 0 yes kegg kegg NA NA no no no no no no 14:0/16:0-PC+blood total_blood_mcfa+blood -0.463157895 0 -0.42017094 serum_phospholipids serum_mcfa 0.0358 8.76E-11 no up no dn dn dn 14:0/18:0-PC+blood total_blood_mcfa+blood 0 0 -0.422905983 serum_phospholipids serum_mcfa 0.00289 8.76E-11 up up no dn dn dn 16:0/16:1-PC+blood total_blood_mcfa+blood 0 0 -0.452307692 serum_phospholipids serum_mcfa 0.00283 8.76E-11 up up no dn dn dn 16:0/16:1-PI+blood total_blood_mcfa+blood 0 0 -0.543247863 serum_phospholipids serum_mcfa 0.262 8.76E-11 no no no dn dn dn 16:0/18:2-PI+blood total_blood_mcfa+blood 0 0 -0.442735043 serum_phospholipids serum_mcfa 0.269 8.76E-11 no no no dn dn dn 16:0/18:3-PC+blood total_blood_mcfa+blood -0.502255639 0 -0.517948718 serum_phospholipids serum_mcfa 0.00216 8.76E-11 no up up dn dn dn 16:0/20:3-PC+blood total_blood_mcfa+blood 0 0.593137255 0 serum_phospholipids serum_mcfa 5.43E-06 8.76E-11 no up up dn dn dn 16:0/20:4-PI+blood total_blood_mcfa+blood 0 0 -0.47965812 serum_phospholipids serum_mcfa 0.558 8.76E-11 no no no dn dn dn 16:0/22:6-PE+blood total_blood_mcfa+blood 0 -0.507352941 0 serum_phospholipids serum_mcfa 0.000934 8.76E-11 up up no dn dn dn 18:0-LPE+blood total_blood_mcfa+blood 0 0 -0.452991453 serum_phospholipids serum_mcfa 0.491 8.76E-11 no no no dn dn dn 18:0/22:6-PE+blood total_blood_mcfa+blood 0 -0.568627451 0 serum_phospholipids serum_mcfa 0.00022 8.76E-11 up up no dn dn dn 18:0+blood total_blood_mcfa+blood 0 0 -0.484444444 serum_fattyacid serum_mcfa 0.344 8.76E-11 no no no dn dn dn 18:1/16:0-PE+blood total_blood_mcfa+blood -0.50075188 0 0 serum_phospholipids serum_mcfa 0.000182 8.76E-11 up up no dn dn dn 18:1/18:1-PC+blood total_blood_mcfa+blood 0 0.580882353 0 serum_phospholipids serum_mcfa 1.34E-05 8.76E-11 no up up dn dn dn 18:1/20:3-PC+blood total_blood_mcfa+blood 0 0.595588235 0 serum_phospholipids serum_mcfa 0.00872 8.76E-11 no up up dn dn dn 18:1/20:4-PE+blood total_blood_mcfa+blood 0 -0.519607843 0 serum_phospholipids serum_mcfa 0.0578 8.76E-11 up no no dn dn dn 18:1/20:4-PI+blood total_blood_mcfa+blood 0 0 -0.505641026 serum_phospholipids serum_mcfa 0.192 8.76E-11 no no no dn dn dn 18:2-LPC+blood total_blood_mcfa+blood 0.521804511 0 0 serum_phospholipids serum_mcfa 0.00743 8.76E-11 dn no up dn dn dn 18:2-LPE+blood total_blood_mcfa+blood 0 0.62745098 0 serum_phospholipids serum_mcfa 0.112 8.76E-11 no no no dn dn dn 18:3/16:0-PE+blood total_blood_mcfa+blood -0.673684211 0 -0.422905983 serum_phospholipids serum_mcfa 0.00149 8.76E-11 up up no dn dn dn 18:3n6+blood total_blood_mcfa+blood 0 0 -0.591111111 serum_fattyacid serum_mcfa 0.0463 8.76E-11 up no dn dn dn dn 2-methyl-butyric acid m-C4+blood total_blood_mcfa+blood 0.621052632 0 0 serum_scfa serum_mcfa 0.262 8.76E-11 no no no dn dn dn 20:2/18:0-PC+blood total_blood_mcfa+blood 0 0 -0.401709402 serum_phospholipids serum_mcfa 0.0427 8.76E-11 no up no dn dn dn 20:2+blood total_blood_mcfa+blood 0 0.617647059 0 serum_fattyacid serum_mcfa 0.478 8.76E-11 no no no dn dn dn 20:3-LPE+blood total_blood_mcfa+blood 0 0.600490196 0 serum_phospholipids serum_mcfa 0.084 8.76E-11 no up no dn dn dn 20:5-LPC+blood total_blood_mcfa+blood 0 -0.654411765 0 serum_phospholipids serum_mcfa 0.558 8.76E-11 no no no dn dn dn 22:1-LPA+blood total_blood_mcfa+blood 0 0.541666667 0 serum_phospholipids serum_mcfa 0.00373 8.76E-11 no up up dn dn dn 22:2-LPA+blood total_blood_mcfa+blood 0 0.588235294 0 serum_phospholipids serum_mcfa 0.0443 8.76E-11 dn no no dn dn dn 22:6-LPC+blood total_blood_mcfa+blood 0 -0.549019608 0 serum_phospholipids serum_mcfa 0.127 8.76E-11 no no up dn dn dn 24:0+blood total_blood_mcfa+blood 0 0 -0.401025641 serum_fattyacid serum_mcfa 0.034 8.76E-11 dn no up dn dn dn 9-HODE+blood total_blood_mcfa+blood 0 0 -0.401709402 serum_ARA serum_mcfa 0.297 8.76E-11 no no no dn dn dn acetic acid C2+blood total_blood_mcfa+blood 0.458646617 0 0 serum_scfa serum_mcfa 0.000193 8.76E-11 up dn no dn dn dn capric acid C6+blood total_blood_mcfa+blood 0 0 0.515213675 serum_scfa serum_mcfa 0.433 8.76E-11 no no no dn dn dn Creatinine+blood total_blood_mcfa+blood 0.493233083 0 0 serum_choline serum_mcfa 0.437 8.76E-11 no no no dn dn dn Cysteine+blood total_blood_mcfa+blood 0 0.600490196 0 yes serum_aminoacids serum_mcfa 1.81E-07 8.76E-11 dn up up dn dn dn d18:1-14:1-SM+blood total_blood_mcfa+blood -0.466165414 0 0 serum_phospholipids serum_mcfa 0.0952 8.76E-11 no dn no dn dn dn d18:1-20:0-SM+blood total_blood_mcfa+blood -0.467669173 0 0 serum_phospholipids serum_mcfa 0.933 8.76E-11 no no no dn dn dn decanoic acid C10+blood total_blood_mcfa+blood 0.957894737 0.654411765 0.714188034 serum_mcfa serum_mcfa 6.64E-11 8.76E-11 dn dn no dn dn dn HDCA+blood total_blood_mcfa+blood 0 0 0.548008999 serum_bileacids serum_mcfa 0.483 8.76E-11 no no no dn dn dn heptanoic acid C7+blood total_blood_mcfa+blood 0.82556391 0.833333333 0.447521368 serum_mcfa serum_mcfa 8.27E-11 8.76E-11 dn dn no dn dn dn isobutyric acid C4+blood total_blood_mcfa+blood 0.571428571 0 0 serum_scfa serum_mcfa 0.0151 8.76E-11 up up no dn dn dn L-Alanine+blood total_blood_mcfa+blood 0 0 -0.558974359 yes serum_aminoacids serum_mcfa 0.00138 8.76E-11 up up no dn dn dn L-Asparagine+blood total_blood_mcfa+blood 0.482706767 0 0 serum_aminoacids serum_mcfa 0.784 8.76E-11 no no no dn dn dn L-Lysine+blood total_blood_mcfa+blood 0.476691729 0.504901961 0 yes serum_aminoacids serum_mcfa 0.0107 8.76E-11 no up no dn dn dn L-Tryptophan+blood total_blood_mcfa+blood 0 0 0.42017094 serum_aminoacids serum_mcfa 0.164 8.76E-11 no no no dn dn dn lauric acid C12+blood total_blood_mcfa+blood 0.82406015 0.987745098 0.949401709 serum_mcfa serum_mcfa 0.015 8.76E-11 no dn dn dn dn dn n6/n3+blood total_blood_mcfa+blood 0 0.656862745 0 serum_fattyacid serum_mcfa 0.226 8.76E-11 no no no dn dn dn nonanoic acid C9+blood total_blood_mcfa+blood 0.926315789 0.941176471 0.808547009 serum_mcfa serum_mcfa 6.51E-11 8.76E-11 dn dn no dn dn dn octanoic acid C8+blood total_blood_mcfa+blood 0.864661654 0.757352941 0.464615385 serum_mcfa serum_mcfa 2.84E-11 8.76E-11 dn dn dn dn dn dn propionic acid C3+blood total_blood_mcfa+blood 0.606015038 0 0 serum_scfa serum_mcfa 0.104 8.76E-11 no dn no dn dn dn Sarcosine+blood total_blood_mcfa+blood 0 0 -0.428376068 serum_choline serum_mcfa 5.06E-05 8.76E-11 up up no dn dn dn TMAO+blood total_blood_mcfa+blood 0 0 0.463931624 serum_choline serum_mcfa 0.00706 8.76E-11 up up no dn dn dn 14:0-LPC+blood total_blood_scfa+blood 0 0 -0.40991453 serum_phospholipids serum_scfa 0.00689 0.168 up up no no no no 16:0-LPC+blood total_blood_scfa+blood 0 0 -0.437264957 serum_phospholipids serum_scfa 0.00456 0.168 up up no no no no 16:0-LPE+blood total_blood_scfa+blood 0 0 -0.435213675 serum_phospholipids serum_scfa 0.0711 0.168 up up no no no no 16:0/16:0-PI+blood total_blood_scfa+blood 0 0 -0.50974359 serum_phospholipids serum_scfa 0.358 0.168 no no no no no no 16:0/16:1-PI+blood total_blood_scfa+blood 0 0 -0.563760684 serum_phospholipids serum_scfa 0.262 0.168 no no no no no no 16:0/18:2-PI+blood total_blood_scfa+blood 0 0 -0.556239316 serum_phospholipids serum_scfa 0.269 0.168 no no no no no no 16:0/20:4-PI+blood total_blood_scfa+blood 0 0 -0.51042735 serum_phospholipids serum_scfa 0.558 0.168 no no no no no no 18:0-LPA+blood total_blood_scfa+blood 0 0.585784314 0 serum_phospholipids serum_scfa 0.0725 0.168 no dn no no no no 18:0/18:2-PI+blood total_blood_scfa+blood 0 0 -0.468034188 serum_phospholipids serum_scfa 0.179 0.168 no no no no no no 18:0/22:6-PI+blood total_blood_scfa+blood 0 0.504901961 0 serum_phospholipids serum_scfa 0.425 0.168 no no no no no no 18:1-LPC+blood total_blood_scfa+blood 0.460150376 0 0 serum_phospholipids serum_scfa 0.179 0.168 no no no no no no 18:1-LPE+blood total_blood_scfa+blood 0 0 -0.431794872 serum_phospholipids serum_scfa 0.117 0.168 no no no no no no 18:1/16:0-PI+blood total_blood_scfa+blood 0 0.5 0 serum_phospholipids serum_scfa 0.793 0.168 no no no no no no 18:1/18:0-PI+blood total_blood_scfa+blood 0 0 -0.432478632 serum_phospholipids serum_scfa 0.0931 0.168 no no up no no no 18:2-LPE+blood total_blood_scfa+blood 0 0 -0.487863248 serum_phospholipids serum_scfa 0.112 0.168 no no no no no no 18:3n6+blood total_blood_scfa+blood 0 0 -0.453675214 serum_fattyacid serum_scfa 0.0463 0.168 up no dn no no no 20:0+blood total_blood_scfa+blood 0 0 -0.716239316 yes serum_fattyacid serum_scfa 0.000278 0.168 dn no up no no no 20:1-LPA+blood total_blood_scfa+blood -0.460150376 0.509803922 0 serum_phospholipids serum_scfa 0.0187 0.168 dn dn no no no no 20:1-LPC+blood total_blood_scfa+blood 0.607518797 0 0 serum_phospholipids serum_scfa 0.217 0.168 no no no no no no 20:1-LPE+blood total_blood_scfa+blood 0.622556391 0 0 serum_phospholipids serum_scfa 0.465 0.168 no no no no no no 20:2-LPE+blood total_blood_scfa+blood 0.621052632 0 0 serum_phospholipids serum_scfa 0.177 0.168 no no no no no no acetic acid C2+blood total_blood_scfa+blood 0 0 0.669059829 serum_scfa serum_scfa 0.000193 0.168 up dn no no no no CA+blood total_blood_scfa+blood 0 -0.568976195 0 serum_bileacids serum_scfa 0.606 0.168 no no no no no no capric acid C6+blood total_blood_scfa+blood 0.833082707 0.806372549 0.909059829 serum_scfa serum_scfa 0.433 0.168 no no no no no no decanoic acid C10+blood total_blood_scfa+blood 0 0 0.461196581 serum_mcfa serum_scfa 6.64E-11 0.168 dn dn no no no no GCA+blood total_blood_scfa+blood 0 -0.517156863 0 yes serum_bileacids serum_scfa 0.16 0.168 no no no no no no GCDCA+blood total_blood_scfa+blood 0 -0.517156863 0 serum_bileacids serum_scfa 0.31 0.168 no no no no no no HCA+blood total_blood_scfa+blood 0 -0.547407623 0 serum_bileacids serum_scfa 0.544 0.168 no no no no no no isocapric acid iso-C6+blood total_blood_scfa+blood 0 0.50245098 0 serum_scfa serum_scfa 0.0458 0.168 no no dn no no no L-Alanine+blood total_blood_scfa+blood 0 -0.50245098 -0.656752137 yes serum_aminoacids serum_scfa 0.00138 0.168 up up no no no no Sarcosine+blood total_blood_scfa+blood 0 0 -0.579487179 serum_choline serum_scfa 5.06E-05 0.168 up up no no no no TDCA+blood total_blood_scfa+blood 0 -0.493931731 0 yes serum_bileacids serum_scfa 0.155 0.168 no up no no no no 5-Hydroxytryptamine+stool total_stool_scfa+stool 0 0 -0.415019763 stool_cometabolism stool_scfa 0.00862 0.0534 dn dn no dn no up Acetic acid+stool total_stool_scfa+stool 0.907120743 0.818181818 0.908102767 yes stool_scfa stool_scfa 0.0656 0.0534 dn no no dn no up Adrenergic signaling in cardiomyocytes total_stool_scfa+stool 0 0.618181818 0 kegg stool_scfa NA 0.0534 no no up dn no up Akkermansia total_stool_scfa+stool -0.534529496 0 0 acetate-producing Genus stool_scfa 0.23 0.0534 no no no dn no up Alcoholism total_stool_scfa+stool 0 0 -0.45567476 kegg stool_scfa NA 0.0534 no no no dn no up Amoebiasis total_stool_scfa+stool -0.473684211 0 0 kegg stool_scfa NA 0.0534 no no no dn no up AMPK signaling pathway total_stool_scfa+stool 0.494324045 0 0 kegg stool_scfa NA 0.0534 no no no dn no up Apelin signaling pathway total_stool_scfa+stool 0.562435501 0 0 kegg stool_scfa NA 0.0534 no no no dn no up Bacteroides total_stool_scfa+stool -0.479876161 0 0 LPS-producing Genus stool_scfa 0.000267 0.0534 dn dn up dn no up Butyric acid+stool total_stool_scfa+stool 0.805985552 0.664335664 0.881422925 yes stool_scfa stool_scfa 0.102 0.0534 dn no no dn no up Butyricicoccus total_stool_scfa+stool 0 0 0.478686764 butyrate-producing Genus stool_scfa 0.852 0.0534 no no no dn no up CA+stool total_stool_scfa+stool -0.618163055 0 0 stool_bileacids stool_scfa 0.827 0.0534 no no no dn no up Cell cycle total_stool_scfa+stool 0.488132095 0 0 kegg stool_scfa NA 0.0534 no no no dn no up Chemokine signaling pathway total_stool_scfa+stool -0.595459236 0 0 kegg stool_scfa NA 0.0534 no no no dn no up Coprococcus total_stool_scfa+stool 0 0 0.496047431 butyrate-producing Genus stool_scfa 0.612 0.0534 no no no dn no up Coronavirus disease - COVID-19 total_stool_scfa+stool 0.500515996 0 0 kegg stool_scfa NA 0.0534 no no no dn no up DCA+stool total_stool_scfa+stool 0 0 0.494071146 stool_bileacids stool_scfa 0.195 0.0534 no no no dn no up EGFR tyrosine kinase inhibitor resistance total_stool_scfa+stool 0.572755418 0 0 kegg stool_scfa NA 0.0534 no no no dn no up Epithelial cell signaling in Helicobacter pylori infection total_stool_scfa+stool -0.527347781 0 0 kegg stool_scfa NA 0.0534 no no no dn no up Fusobacterium total_stool_scfa+stool 0 0 -0.458157542 Genus stool_scfa 0.628 0.0534 no no no dn no up GCDCA+stool total_stool_scfa+stool 0 -0.587412587 0 yes stool_bileacids stool_scfa 0.0471 0.0534 no dn no dn no up GDCA+stool total_stool_scfa+stool 0 0 -0.477745041 stool_bileacids stool_scfa 0.656 0.0534 no no no dn no up Gemmiger total_stool_scfa+stool 0 0 0.41345223 butyrate-producing Genus stool_scfa 0.595 0.0534 no no no dn no up HDCA+stool total_stool_scfa+stool 0.510835913 0 0 stool_bileacids stool_scfa 0.176 0.0534 no no no dn no up Inflammatory bowel disease total_stool_scfa+stool 0 -0.645454545 0 kegg stool_scfa NA 0.0534 no no no dn no up Insulin signaling pathway total_stool_scfa+stool 0.517027864 0 0 kegg stool_scfa NA 0.0534 no no no dn no up iso-DCA+stool total_stool_scfa+stool 0.488132095 0 0 stool_bileacids stool_scfa 0.155 0.0534 no no no dn no up Isobutyric acid+stool total_stool_scfa+stool 0 0.664335664 0 stool_scfa stool_scfa 0.408 0.0534 no no no dn no up Isovaleric acid+stool total_stool_scfa+stool 0 0.657342657 0 stool_scfa stool_scfa 0.343 0.0534 no no no dn no up L-Tryptophan+stool total_stool_scfa+stool -0.525283798 0 0 stool_cometabolism stool_scfa 0.557 0.0534 no no no dn no up Morphine addiction total_stool_scfa+stool 0 0 -0.438735178 kegg stool_scfa NA 0.0534 no up up dn no up mTOR signaling pathway total_stool_scfa+stool 0.564499484 0 0 kegg stool_scfa NA 0.0534 no no no dn no up Phenylacetic acid+stool total_stool_scfa+stool 0 0.615384615 0 stool_cometabolism stool_scfa 0.785 0.0534 no no no dn no up Phospholipase D signaling pathway total_stool_scfa+stool -0.471620227 0 0 kegg stool_scfa NA 0.0534 no up up dn no up Propionic acid+stool total_stool_scfa+stool 0.876160991 0.776223776 0.87944664 yes stool_scfa stool_scfa 0.0436 0.0534 dn no up dn no up Ribosome total_stool_scfa+stool 0.496388029 0 0 kegg stool_scfa NA 0.0534 no no no dn no up Roseburia total_stool_scfa+stool 0 -0.676008042 0 butyrate-producing Genus stool_scfa 0.495 0.0534 no no no dn no up T-¦Á-MCA+stool total_stool_scfa+stool 0.507665688 0 0 stool_bileacids stool_scfa 0.48 0.0534 no no no dn no up TCA+stool total_stool_scfa+stool 0 0 -0.46541502 stool_bileacids stool_scfa 0.458 0.0534 no no no dn no up TLCA+stool total_stool_scfa+stool 0 0.678425735 0 stool_bileacids stool_scfa 0.243 0.0534 no no no dn no up ¦Ø-MCA+stool total_stool_scfa+stool -0.650312317 0 0 stool_bileacids stool_scfa 0.919 0.0534 no no no dn no up Adrenergic signaling in cardiomyocytes Toxoplasmosis -0.523478261 -0.693675889 -0.477477477 kegg kegg NA NA no no up no no no Alcoholism Toxoplasmosis -0.616521739 0 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Toxoplasmosis -0.502608696 -0.7243083 -0.403603604 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Toxoplasmosis 0.500869565 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Toxoplasmosis 0 -0.616600791 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Toxoplasmosis 0.446956522 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Toxoplasmosis -0.427826087 -0.664031621 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Toxoplasmosis 0 -0.658102767 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Toxoplasmosis -0.439130435 -0.595849802 0 kegg kegg NA NA no no no no no no Anaerostipes Toxoplasmosis -0.459159169 0 0 butyrate-producing Genus kegg 0.568 NA no no no no no no Apoptosis Toxoplasmosis 0 0.529644269 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Toxoplasmosis 0 0.447628458 0 kegg kegg NA NA no up no no no no Axon guidance Toxoplasmosis -0.486086957 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Toxoplasmosis 0 0.572134387 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Toxoplasmosis 0.52173913 0 0.673101673 kegg kegg NA NA no no no no no no Bile secretion Toxoplasmosis -0.537391304 -0.710474308 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Toxoplasmosis 0 0.4743083 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Toxoplasmosis 0 -0.515810277 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Toxoplasmosis 0.574782609 0 0.4996139 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Toxoplasmosis 0 0.54743083 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Toxoplasmosis -0.494782609 -0.637351779 -0.486486486 kegg kegg NA NA no up up no no no cAMP signaling pathway Toxoplasmosis -0.473043478 0 -0.461003861 yes kegg kegg NA NA no up up no no no Carbon metabolism Toxoplasmosis 0 0.469367589 0.442213642 kegg kegg NA NA no no no no no no Cardiac muscle contraction Toxoplasmosis 0 -0.608695652 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Toxoplasmosis 0 0.622529644 0 kegg kegg NA NA no no no no no no Cellular senescence Toxoplasmosis 0 0.460474308 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Toxoplasmosis 0 0.494071146 0 kegg kegg NA NA no no no no no no Cholesterol metabolism Toxoplasmosis 0 0.639328063 0 yes kegg kegg NA NA no no up no no no Circadian entrainment Toxoplasmosis -0.406086957 -0.583003953 0 kegg kegg NA NA no up up no no no Circadian rhythm Toxoplasmosis 0 -0.414031621 0 kegg kegg NA NA no no no no no no Cocaine addiction Toxoplasmosis -0.46173913 -0.709486166 -0.417760618 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Toxoplasmosis -0.410434783 -0.706521739 -0.408494208 kegg kegg NA NA no no up no no no Cushing syndrome Toxoplasmosis -0.492173913 -0.660079051 -0.423680824 kegg kegg NA NA no no up no no no Dopaminergic synapse Toxoplasmosis -0.494782609 -0.776679842 -0.404890605 kegg kegg NA NA no up no no no no Endocrine and other factor-regulated calcium reabsorption Toxoplasmosis -0.470434783 -0.777667984 0 kegg kegg NA NA no no no no no no Endocrine resistance Toxoplasmosis 0 -0.630434783 0 kegg kegg NA NA no no no no no no Endocytosis Toxoplasmosis 0 0.564229249 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Toxoplasmosis 0 0.459486166 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Toxoplasmosis 0.434782609 0 0 yes kegg kegg NA NA no up up no no no Fatty acid degradation Toxoplasmosis 0.495652174 0.481225296 0 kegg kegg NA NA no no no no no no Fatty acid elongation Toxoplasmosis 0 0 0.556499356 kegg kegg NA NA no no no no no no Fatty acid metabolism Toxoplasmosis 0.532173913 0.47826087 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Toxoplasmosis 0 0.438735178 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Toxoplasmosis 0 0.530632411 0 kegg kegg NA NA no no no no no no Galactose metabolism Toxoplasmosis 0.549565217 0.481225296 0 kegg kegg NA NA no no no no no no Gap junction Toxoplasmosis 0 -0.551383399 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Toxoplasmosis -0.48 -0.682806324 0 kegg kegg NA NA no no no no no no Glutathione metabolism Toxoplasmosis 0 -0.65513834 0 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Toxoplasmosis 0 -0.593873518 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Toxoplasmosis 0 0 0.599485199 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Toxoplasmosis -0.502608696 0 -0.414157014 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Toxoplasmosis 0 0.59486166 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Toxoplasmosis 0 0 -0.561389961 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Toxoplasmosis 0.453043478 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Toxoplasmosis -0.530434783 -0.669960474 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Toxoplasmosis 0.604347826 0.469367589 0.807207207 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Toxoplasmosis 0 0.549407115 0 kegg kegg NA NA no no no no no no Histidine metabolism Toxoplasmosis 0.584347826 0.448616601 0.489317889 kegg kegg NA NA no no no no no no Huntington disease Toxoplasmosis 0 -0.628458498 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Toxoplasmosis 0 0.509881423 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Toxoplasmosis -0.474782609 -0.66798419 0 kegg kegg NA NA no no no no no no Insulin secretion Toxoplasmosis 0 -0.693675889 -0.430888031 yes kegg kegg NA NA no up up no no no Intestinal immune network for IgA production Toxoplasmosis 0 0 0.684169884 kegg kegg NA NA no no no no no no Leishmaniasis Toxoplasmosis 0 0 0.481081081 kegg kegg NA NA no no no no no no Long-term depression Toxoplasmosis -0.502608696 -0.484189723 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Toxoplasmosis 0 0.41798419 0.510682111 kegg kegg NA NA no no no no no no Lysosome Toxoplasmosis 0 0.563241107 0 kegg kegg NA NA no no no no no no Melanogenesis Toxoplasmosis -0.512173913 -0.641304348 0 kegg kegg NA NA no no no no no no Mineral absorption Toxoplasmosis -0.573043478 -0.541501976 0 kegg kegg NA NA no no no no no no Mitophagy - animal Toxoplasmosis -0.57826087 -0.631422925 0 kegg kegg NA NA no no no no no no Morphine addiction Toxoplasmosis -0.585217391 -0.764822134 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Toxoplasmosis 0 0 -0.401287001 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Toxoplasmosis 0 0.494071146 0 kegg kegg NA NA no no no no no no Necroptosis Toxoplasmosis -0.433043478 0 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Toxoplasmosis 0 0.551383399 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Toxoplasmosis 0 0.433794466 -0.406435006 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Toxoplasmosis 0.435652174 0.612648221 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Toxoplasmosis 0 -0.641304348 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Toxoplasmosis 0.437391304 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Toxoplasmosis 0 0.60770751 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Toxoplasmosis 0 -0.727272727 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Toxoplasmosis 0 -0.613636364 0 kegg kegg NA NA no no no no no no Pancreatic secretion Toxoplasmosis -0.564347826 -0.591897233 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Toxoplasmosis 0 0.476284585 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Toxoplasmosis -0.596521739 -0.602766798 0 kegg kegg NA NA no no no no no no Parkinson disease Toxoplasmosis -0.583478261 -0.661067194 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Toxoplasmosis 0 0.578063241 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Toxoplasmosis -0.560869565 -0.651185771 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Toxoplasmosis 0 0.484189723 0 kegg kegg NA NA no no no no no no Peroxisome Toxoplasmosis 0 0.496047431 0 kegg kegg NA NA no no no no no no Pertussis Toxoplasmosis 0.414782609 0.628458498 0 kegg kegg NA NA no no dn no no no Phagosome Toxoplasmosis 0 0.580039526 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Toxoplasmosis 0 0 -0.467438867 kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism Toxoplasmosis 0 -0.491106719 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Toxoplasmosis 0 0.482213439 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Toxoplasmosis 0.439130435 0 0.487001287 kegg kegg NA NA no no no no no no Prion disease Toxoplasmosis 0 -0.540513834 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Toxoplasmosis 0 0.427865613 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Toxoplasmosis 0.697391304 0.723320158 0 yes kegg kegg NA NA no up up no no no Purine metabolism Toxoplasmosis 0 -0.59486166 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Toxoplasmosis 0.470434783 0 0 kegg kegg NA NA no no no no no no Ras signaling pathway Toxoplasmosis -0.464347826 0 0 yes kegg kegg NA NA no up up no no no Regulation of lipolysis in adipocytes Toxoplasmosis -0.529565217 -0.768774704 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Toxoplasmosis -0.502608696 0 -0.428828829 kegg kegg NA NA no no no no no no Renin secretion Toxoplasmosis -0.406086957 -0.641304348 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Toxoplasmosis 0 0.619565217 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Toxoplasmosis 0 -0.640316206 0 kegg kegg NA NA no no up no no no Ribosome Toxoplasmosis -0.470434783 -0.469367589 0 kegg kegg NA NA no no no no no no Salmonella infection Toxoplasmosis 0 0.716403162 0 kegg kegg NA NA no no no no no no Shigellosis Toxoplasmosis -0.573913043 -0.518774704 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Toxoplasmosis 0.44173913 0.454545455 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Toxoplasmosis 0 0.428853755 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Toxoplasmosis 0 0.485177866 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Toxoplasmosis 0.488695652 0.830039526 0.484684685 kegg kegg NA NA no no no no no no Th17 cell differentiation Toxoplasmosis 0.562608696 0.835968379 0.553153153 kegg kegg NA NA no no no no no no Thermogenesis Toxoplasmosis -0.417391304 -0.60770751 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Toxoplasmosis 0 -0.773715415 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Toxoplasmosis 0 0.473320158 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Toxoplasmosis 0.407826087 0 0.406949807 kegg kegg NA NA no up no no no no Type I diabetes mellitus Toxoplasmosis 0 0.577075099 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Toxoplasmosis -0.54 -0.645256917 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Toxoplasmosis -0.68173913 -0.638339921 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Toxoplasmosis -0.463478261 -0.77173913 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Toxoplasmosis 0 0 -0.407464607 kegg kegg NA NA no no no no no no Wnt signaling pathway Toxoplasmosis -0.487826087 0 0 kegg kegg NA NA no no no no no no Yersinia infection Toxoplasmosis 0 0.468379447 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Transcriptional misregulation in cancer -0.484347826 -0.614624506 0 kegg kegg NA NA no no no no no no ABC transporters Transcriptional misregulation in cancer 0 0.564229249 0 kegg kegg NA NA no up up no no no Adherens junction Transcriptional misregulation in cancer -0.766956522 -0.848814229 -0.612612613 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Transcriptional misregulation in cancer 0 0.663043478 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Transcriptional misregulation in cancer 0 -0.551383399 0 kegg kegg NA NA no no up no no no African trypanosomiasis Transcriptional misregulation in cancer 0 0.593873518 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Transcriptional misregulation in cancer 0 0.809288538 0.58970399 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Transcriptional misregulation in cancer 0.513913043 0.77173913 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Transcriptional misregulation in cancer 0 -0.429841897 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Transcriptional misregulation in cancer 0.455652174 0.448616601 0.454054054 kegg kegg NA NA no no no no no no Alistipes Transcriptional misregulation in cancer -0.517035497 0 0 Genus kegg 0.0114 NA no up no no no no alpha-Linolenic acid metabolism Transcriptional misregulation in cancer 0 0.559288538 0 kegg kegg NA NA no no no no no no Alzheimer disease Transcriptional misregulation in cancer 0 -0.705533597 0 kegg kegg NA NA no no no no no no Amoebiasis Transcriptional misregulation in cancer 0 0.661067194 0 kegg kegg NA NA no no no no no no Amphetamine addiction Transcriptional misregulation in cancer 0 -0.543478261 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Transcriptional misregulation in cancer -0.410434783 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Transcriptional misregulation in cancer 0 -0.708498024 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Transcriptional misregulation in cancer 0 -0.783596838 0 kegg kegg NA NA no no no no no no Apoptosis Transcriptional misregulation in cancer 0 0.584980237 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Transcriptional misregulation in cancer 0.412173913 0.51284585 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Transcriptional misregulation in cancer -0.465217391 0 -0.485971686 kegg kegg NA NA no no no no no no Arginine and proline metabolism Transcriptional misregulation in cancer 0 0.723320158 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Transcriptional misregulation in cancer 0.439130435 0.706521739 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Transcriptional misregulation in cancer 0 -0.42687747 0 kegg kegg NA NA no no no no no no Autophagy - animal Transcriptional misregulation in cancer 0.824347826 0.938735178 0.482368082 kegg kegg NA NA no no no no no no Autophagy - other Transcriptional misregulation in cancer 0.790434783 0.627470356 0.605405405 kegg kegg NA NA no no no no no no Axon guidance Transcriptional misregulation in cancer 0.437391304 0 0.492149292 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Transcriptional misregulation in cancer 0.448695652 0.720355731 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Transcriptional misregulation in cancer -0.675652174 -0.749011858 -0.702702703 kegg kegg NA NA no no no no no no Bacteroides Transcriptional misregulation in cancer 0 -0.427865613 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no beta-Alanine metabolism Transcriptional misregulation in cancer 0 -0.536561265 -0.584555985 kegg kegg NA NA no no no no no no Bifidobacterium Transcriptional misregulation in cancer 0 -0.414562935 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Bile secretion Transcriptional misregulation in cancer -0.453913043 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Transcriptional misregulation in cancer -0.536521739 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Transcriptional misregulation in cancer 0 -0.744071146 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Transcriptional misregulation in cancer 0.75826087 0.774703557 0.667181467 kegg kegg NA NA no no no no no no Calcium signaling pathway Transcriptional misregulation in cancer 0 0 0.408751609 kegg kegg NA NA no up up no no no cAMP signaling pathway Transcriptional misregulation in cancer 0 0.415019763 0.421621622 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Transcriptional misregulation in cancer 0.662608696 0.666007905 0 kegg kegg NA NA no no no no no no Carbon metabolism Transcriptional misregulation in cancer 0 -0.418972332 -0.423680824 kegg kegg NA NA no no no no no no Cardiac muscle contraction Transcriptional misregulation in cancer 0 -0.693675889 0 kegg kegg NA NA no no up no no no cGMP-PKG signaling pathway Transcriptional misregulation in cancer 0.511304348 0.46541502 0 kegg kegg NA NA no no no no no no Chagas disease Transcriptional misregulation in cancer 0.410434783 0.757905138 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Transcriptional misregulation in cancer 0 0.440711462 0 kegg kegg NA NA no no no no no no Cholinergic synapse Transcriptional misregulation in cancer 0.537391304 0 0 kegg kegg NA NA no no no no no no Circadian entrainment Transcriptional misregulation in cancer -0.529565217 -0.646245059 0 kegg kegg NA NA no up up no no no Circadian rhythm Transcriptional misregulation in cancer 0.530434783 0 0.468468468 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Transcriptional misregulation in cancer 0 -0.733201581 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Transcriptional misregulation in cancer 0 0.427865613 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Transcriptional misregulation in cancer 0 -0.711462451 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Transcriptional misregulation in cancer 0 -0.731225296 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Transcriptional misregulation in cancer 0 0 -0.473873874 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Transcriptional misregulation in cancer 0 0.464426877 0 kegg kegg NA NA no no no no no no DNA replication Transcriptional misregulation in cancer 0 -0.637351779 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Transcriptional misregulation in cancer 0 -0.597826087 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Transcriptional misregulation in cancer 0 -0.822134387 -0.448906049 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Transcriptional misregulation in cancer 0 -0.854743083 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Transcriptional misregulation in cancer 0 -0.652173913 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Transcriptional misregulation in cancer -0.525217391 -0.545454545 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Transcriptional misregulation in cancer 0 0.574110672 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Transcriptional misregulation in cancer 0.454782609 0.617588933 0.487773488 kegg kegg NA NA no no no no no no Estrogen signaling pathway Transcriptional misregulation in cancer 0 -0.593873518 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Transcriptional misregulation in cancer 0.485217391 0.711462451 0 kegg kegg NA NA no no no no no no Fatty acid degradation Transcriptional misregulation in cancer 0 0.511857708 0 kegg kegg NA NA no no no no no no Fatty acid elongation Transcriptional misregulation in cancer 0 -0.556324111 -0.415186615 kegg kegg NA NA no no no no no no Fatty acid metabolism Transcriptional misregulation in cancer 0 0.451581028 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Transcriptional misregulation in cancer 0 0.742094862 0 kegg kegg NA NA no no no no no no Focal adhesion Transcriptional misregulation in cancer -0.723478261 -0.860671937 -0.586872587 kegg kegg NA NA no up up no no no FoxO signaling pathway Transcriptional misregulation in cancer 0.588695652 0.754940711 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Transcriptional misregulation in cancer 0 0.511857708 0 kegg kegg NA NA no no no no no no GABAergic synapse Transcriptional misregulation in cancer 0.515652174 0.588932806 0 kegg kegg NA NA no up up no no no Galactose metabolism Transcriptional misregulation in cancer 0 0.531620553 0 kegg kegg NA NA no no no no no no Gap junction Transcriptional misregulation in cancer -0.544347826 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Transcriptional misregulation in cancer -0.873913043 -0.856719368 -0.575546976 kegg kegg NA NA no no no no no no Glucagon signaling pathway Transcriptional misregulation in cancer 0 -0.550395257 0 kegg kegg NA NA no no no no no no Glutamatergic synapse Transcriptional misregulation in cancer 0 0.416007905 0 kegg kegg NA NA no up up no no no Glutathione metabolism Transcriptional misregulation in cancer -0.494782609 -0.593873518 -0.406692407 kegg kegg NA NA no no no no no no Glycerolipid metabolism Transcriptional misregulation in cancer 0 0.633399209 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Transcriptional misregulation in cancer 0 0.591897233 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Transcriptional misregulation in cancer -0.526086957 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Transcriptional misregulation in cancer 0 -0.795454545 -0.50990991 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Transcriptional misregulation in cancer 0 0.834980237 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Transcriptional misregulation in cancer -0.57826087 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Transcriptional misregulation in cancer 0 0.415019763 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Transcriptional misregulation in cancer 0 0.695652174 0 kegg kegg NA NA no no no no no no GnRH secretion Transcriptional misregulation in cancer 0.432173913 0.660079051 0 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Transcriptional misregulation in cancer 0 0.526679842 0.415958816 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Transcriptional misregulation in cancer 0 -0.500988142 -0.477992278 kegg kegg NA NA no no no no no no Hepatitis B Transcriptional misregulation in cancer 0.853913043 0.934782609 0.76010296 kegg kegg NA NA no no no no no no Hepatitis C Transcriptional misregulation in cancer 0.645217391 0.537549407 0.694465894 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Transcriptional misregulation in cancer 0 -0.716403162 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Transcriptional misregulation in cancer -0.863478261 -0.845849802 -0.554697555 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Transcriptional misregulation in cancer 0.451304348 0.72826087 0 kegg kegg NA NA no no no no no no Histidine metabolism Transcriptional misregulation in cancer 0 0 -0.418790219 kegg kegg NA NA no no no no no no Human papillomavirus infection Transcriptional misregulation in cancer 0 0.419960474 0 kegg kegg NA NA no no no no no no Huntington disease Transcriptional misregulation in cancer 0 -0.698616601 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Transcriptional misregulation in cancer 0.585217391 0.449604743 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Transcriptional misregulation in cancer 0 -0.62944664 0 kegg kegg NA NA no no no no no no Influenza A Transcriptional misregulation in cancer 0 0 -0.453024453 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Transcriptional misregulation in cancer 0 0.481225296 0 kegg kegg NA NA no no no no no no Insulin resistance Transcriptional misregulation in cancer 0.759130435 0.861660079 0.787387387 kegg kegg NA NA no no no no no no Insulin secretion Transcriptional misregulation in cancer -0.410434783 0 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Transcriptional misregulation in cancer 0 -0.713438735 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Transcriptional misregulation in cancer 0 0.859683794 0 kegg kegg NA NA no no no no no no Lachnospira Transcriptional misregulation in cancer 0 -0.465530036 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Legionellosis Transcriptional misregulation in cancer 0 -0.5 0 kegg kegg NA NA no no no no no no Leishmaniasis Transcriptional misregulation in cancer 0 -0.599802372 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Transcriptional misregulation in cancer -0.462608696 -0.497035573 -0.504247104 kegg kegg NA NA no no no no no no Long-term potentiation Transcriptional misregulation in cancer 0 -0.500988142 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Transcriptional misregulation in cancer 0 0.471343874 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Transcriptional misregulation in cancer 0 0.435770751 0 kegg kegg NA NA no no no no no no Measles Transcriptional misregulation in cancer 0.61826087 0 0 kegg kegg NA NA no no no no no no Melanogenesis Transcriptional misregulation in cancer -0.546956522 -0.62055336 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Transcriptional misregulation in cancer 0 -0.83201581 -0.503989704 kegg kegg NA NA no no no no no no Mismatch repair Transcriptional misregulation in cancer 0 -0.522727273 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Transcriptional misregulation in cancer 0 -0.624505929 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Transcriptional misregulation in cancer 0 -0.65513834 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Transcriptional misregulation in cancer 0.569565217 0.623517787 0.541827542 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Transcriptional misregulation in cancer 0.663478261 0.924901186 0.786100386 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Transcriptional misregulation in cancer 0.449565217 0.719367589 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Transcriptional misregulation in cancer 0 0.70256917 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Transcriptional misregulation in cancer 0.486956522 0.776679842 0.423680824 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Transcriptional misregulation in cancer 0 -0.592885375 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Transcriptional misregulation in cancer 0 -0.610671937 0 kegg kegg NA NA no no no no no no Notch signaling pathway Transcriptional misregulation in cancer 0 0.509881423 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Transcriptional misregulation in cancer 0 -0.485177866 0 kegg kegg NA NA no no no no no no One carbon pool by folate Transcriptional misregulation in cancer 0 -0.519762846 0 kegg kegg NA NA no no no no no no Oocyte meiosis Transcriptional misregulation in cancer 0 -0.653162055 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Transcriptional misregulation in cancer 0 0.681818182 0 kegg kegg NA NA no no no no no no Other glycan degradation Transcriptional misregulation in cancer 0 0.495059289 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Transcriptional misregulation in cancer 0.427826087 0 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Transcriptional misregulation in cancer -0.655652174 0 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Transcriptional misregulation in cancer 0 -0.695652174 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Transcriptional misregulation in cancer -0.746086957 -0.581027668 -0.598198198 kegg kegg NA NA no no no no no no p53 signaling pathway Transcriptional misregulation in cancer 0.58173913 0.527667984 0 kegg kegg NA NA no no no no no no Pancreatic secretion Transcriptional misregulation in cancer 0 -0.561264822 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Transcriptional misregulation in cancer 0.436521739 0.674901186 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Transcriptional misregulation in cancer 0 -0.4743083 0 kegg kegg NA NA no no no no no no Parkinson disease Transcriptional misregulation in cancer 0 -0.612648221 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Transcriptional misregulation in cancer 0 0 -0.413899614 kegg kegg NA NA no no no no no no Pathways in cancer Transcriptional misregulation in cancer 0.506956522 0.731225296 0.672072072 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Transcriptional misregulation in cancer 0 -0.590909091 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Transcriptional misregulation in cancer 0 -0.712450593 0 kegg kegg NA NA no no no no no no Peroxisome Transcriptional misregulation in cancer 0.417391304 0.665019763 0 kegg kegg NA NA no no no no no no Pertussis Transcriptional misregulation in cancer 0 0.435770751 0 kegg kegg NA NA no no dn no no no Phenylalanine metabolism Transcriptional misregulation in cancer -0.767826087 -0.764822134 -0.641956242 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Transcriptional misregulation in cancer 0 0.726284585 0 kegg kegg NA NA no up up no no no Phototransduction Transcriptional misregulation in cancer 0 -0.721343874 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Transcriptional misregulation in cancer 0.486086957 0 0 yes kegg kegg NA NA no up up no no no Platelet activation Transcriptional misregulation in cancer -0.834782609 -0.76284585 -0.524839125 kegg kegg NA NA no no no no no no Platinum drug resistance Transcriptional misregulation in cancer 0.522608696 0.446640316 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Transcriptional misregulation in cancer -0.49826087 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Transcriptional misregulation in cancer 0.452173913 0.606719368 0 kegg kegg NA NA no no no no no no Prevotella Transcriptional misregulation in cancer 0 0.427898299 0 acetate-producing Genus kegg 0.287 NA no no no no no no Primary bile acid biosynthesis Transcriptional misregulation in cancer 0 -0.497035573 0 kegg kegg NA NA no no no no no no Prion disease Transcriptional misregulation in cancer 0 -0.772727273 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Transcriptional misregulation in cancer 0.631304348 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Transcriptional misregulation in cancer 0 0.742094862 0.464607465 kegg kegg NA NA no no no no no no Propanoate metabolism Transcriptional misregulation in cancer 0 -0.707509881 0 kegg kegg NA NA no no no no no no Proteasome Transcriptional misregulation in cancer 0 -0.65513834 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Transcriptional misregulation in cancer 0 0.571146245 0 yes kegg kegg NA NA no up up no no no Protein export Transcriptional misregulation in cancer 0 -0.712450593 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Transcriptional misregulation in cancer 0 -0.610671937 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Transcriptional misregulation in cancer 0 -0.660079051 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Transcriptional misregulation in cancer 0 -0.513833992 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Transcriptional misregulation in cancer 0 -0.747035573 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Transcriptional misregulation in cancer -0.62 -0.581027668 -0.451222651 kegg kegg NA NA no no no no no no Ras signaling pathway Transcriptional misregulation in cancer 0 -0.654150198 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Transcriptional misregulation in cancer -0.513043478 -0.653162055 -0.600772201 kegg kegg NA NA no no no no no no Relaxin signaling pathway Transcriptional misregulation in cancer 0 0.537549407 0 kegg kegg NA NA no no no no no no Renin secretion Transcriptional misregulation in cancer -0.619130435 -0.709486166 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Transcriptional misregulation in cancer 0 -0.747035573 0 kegg kegg NA NA no no up no no no Ribosome Transcriptional misregulation in cancer 0 -0.721343874 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Transcriptional misregulation in cancer 0.852173913 0.90513834 0.732561133 kegg kegg NA NA no no no no no no RNA degradation Transcriptional misregulation in cancer 0 -0.586956522 0 kegg kegg NA NA no no no no no no RNA polymerase Transcriptional misregulation in cancer 0 -0.462450593 0 kegg kegg NA NA no no no no no no RNA transport Transcriptional misregulation in cancer 0 -0.625494071 0 kegg kegg NA NA no no no no no no Roseburia Transcriptional misregulation in cancer -0.48173913 0 0 butyrate-producing Genus kegg 0.495 NA no no no no no no Ruminococcus Transcriptional misregulation in cancer 0 0 0.404990835 Genus kegg 0.0679 NA no no dn no no no Salivary secretion Transcriptional misregulation in cancer -0.433913043 -0.481225296 0 kegg kegg NA NA no no no no no no Salmonella infection Transcriptional misregulation in cancer 0 0 -0.43989704 kegg kegg NA NA no no no no no no Selenocompound metabolism Transcriptional misregulation in cancer 0.448695652 0 0 kegg kegg NA NA no no no no no no Shigellosis Transcriptional misregulation in cancer 0 -0.422924901 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Transcriptional misregulation in cancer 0 0 0.473616474 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Transcriptional misregulation in cancer 0 0.722332016 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Transcriptional misregulation in cancer 0.417391304 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Transcriptional misregulation in cancer 0.696521739 0 0 kegg kegg NA NA no no no no no no Spliceosome Transcriptional misregulation in cancer 0.583478261 0 0.479279279 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Transcriptional misregulation in cancer 0 0.668972332 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Transcriptional misregulation in cancer 0 -0.491106719 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Transcriptional misregulation in cancer 0 -0.54743083 0 kegg kegg NA NA no no no no no no Sulfur metabolism Transcriptional misregulation in cancer -0.469565217 0 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Transcriptional misregulation in cancer 0.582608696 0.627470356 0.511454311 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Transcriptional misregulation in cancer 0 0.67687747 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Transcriptional misregulation in cancer 0 -0.664031621 0 kegg kegg NA NA no no no no no no Thermogenesis Transcriptional misregulation in cancer 0 -0.761857708 0 kegg kegg NA NA no no no no no no Thiamine metabolism Transcriptional misregulation in cancer 0 -0.578063241 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Transcriptional misregulation in cancer -0.693913043 -0.725296443 -0.427284427 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Transcriptional misregulation in cancer -0.440869565 0 0 kegg kegg NA NA no no no no no no Tight junction Transcriptional misregulation in cancer -0.712173913 -0.750988142 -0.72972973 kegg kegg NA NA no no no no no no TNF signaling pathway Transcriptional misregulation in cancer 0.611304348 0.793478261 0.474903475 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Transcriptional misregulation in cancer 0.590434783 0.743083004 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Transcriptional misregulation in cancer 0 -0.605731225 0 kegg kegg NA NA no up no no no no Type II diabetes mellitus Transcriptional misregulation in cancer 0.606086957 0.828063241 0.421106821 kegg kegg NA NA no no no no no no Tyrosine metabolism Transcriptional misregulation in cancer -0.567826087 -0.723320158 -0.620849421 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Transcriptional misregulation in cancer 0 -0.499011858 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Transcriptional misregulation in cancer 0 -0.436758893 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Transcriptional misregulation in cancer 0 -0.65513834 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Transcriptional misregulation in cancer 0 -0.47826087 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Transcriptional misregulation in cancer 0 -0.681818182 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Transcriptional misregulation in cancer -0.514782609 -0.59486166 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Transcriptional misregulation in cancer 0.429565217 0.505928854 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Transcriptional misregulation in cancer -0.831304348 -0.76284585 -0.573230373 kegg kegg NA NA no no no no no no Wnt signaling pathway Transcriptional misregulation in cancer 0 -0.597826087 0 kegg kegg NA NA no no no no no no 2-hydroxyhippuric acid+urine Tryptamine+urine 0 0 -0.466666667 urine_cometabolism urine_cometabolism 0.215 0.0776 no no no no no dn 3-Hydroxy-L-kynurenine+urine Tryptamine+urine 0 0.457894737 0.543247863 urine_cometabolism urine_cometabolism 0.401 0.0776 no no no no no dn 3-Hydroxytyramine hydrochloride+urine Tryptamine+urine 0 0.480701754 0 urine_cometabolism urine_cometabolism 0.288 0.0776 no no no no no dn 5-Hydroxyindole-3-acetic Acid+urine Tryptamine+urine -0.613533835 0 0 urine_cometabolism urine_cometabolism 0.0405 0.0776 no dn dn no no dn 5-Hydroxytryptamine+urine Tryptamine+urine 0 0.545614035 0 urine_cometabolism urine_cometabolism 0.171 0.0776 no no no no no dn Hippuric acid+urine Tryptamine+urine 0 -0.514035088 -0.42974359 urine_cometabolism urine_cometabolism 0.361 0.0776 no no no no no dn Indole-3-Acetic acid+urine Tryptamine+urine -0.469172932 0 -0.516581197 urine_cometabolism urine_cometabolism 0.657 0.0776 no no no no no dn L-Tryptophan+urine Tryptamine+urine 0 0.573684211 0.446837607 urine_cometabolism urine_cometabolism 0.226 0.0776 no no no no no dn L-Tyrosine+urine Tryptamine+urine 0 0.564912281 0.424957265 urine_cometabolism urine_cometabolism 0.45 0.0776 no no no no no dn P-hydroxyhippuric acid+urine Tryptamine+urine 0 -0.529824561 0 urine_cometabolism urine_cometabolism 0.436 0.0776 no no no no no dn Arginine biosynthesis Tryptophan metabolism 0 -0.432806324 0 kegg kegg NA NA no no no no up no Ascorbate and aldarate metabolism Tryptophan metabolism 0.626086957 0.600790514 0.648906049 kegg kegg NA NA no no no no up no Citrate cycle (TCA cycle) Tryptophan metabolism 0.857391304 0.876482213 0.736679537 kegg kegg NA NA no no no no up no Cysteine and methionine metabolism Tryptophan metabolism 0.546956522 0.761857708 0.466409266 kegg kegg NA NA no no no no up no Fatty acid degradation Tryptophan metabolism 0.549565217 0 0.634491634 kegg kegg NA NA no no no no up no Fatty acid elongation Tryptophan metabolism 0.795652174 0.85770751 0.746718147 kegg kegg NA NA no no no no up no Fructose and mannose metabolism Tryptophan metabolism 0.65826087 0 0 kegg kegg NA NA no no no no up no Galactose metabolism Tryptophan metabolism 0.684347826 0 0 kegg kegg NA NA no no no no up no Glycolysis / Gluconeogenesis Tryptophan metabolism 0.794782609 0.738142292 0.634491634 kegg kegg NA NA no no no no up no Histidine metabolism Tryptophan metabolism 0.745217391 0.550395257 0.572200772 kegg kegg NA NA no no no no up no Oxidative phosphorylation Tryptophan metabolism -0.510434783 0 0 kegg kegg NA NA no no no no up no Pentose and glucuronate interconversions Tryptophan metabolism 0.682608696 0.743083004 0 kegg kegg NA NA no no no no up no Phenylalanine metabolism Tryptophan metabolism 0.751304348 0.801383399 0 kegg kegg NA NA no no no no up no Primary bile acid biosynthesis Tryptophan metabolism 0.86173913 0.827075099 0.552638353 kegg kegg NA NA no no no no up no Pyrimidine metabolism Tryptophan metabolism 0.776521739 0.571146245 0 kegg kegg NA NA no no no no up no Steroid biosynthesis Tryptophan metabolism 0 0.77173913 0.478764479 kegg kegg NA NA no no no no up no Steroid hormone biosynthesis Tryptophan metabolism 0.657391304 0.789525692 0 kegg kegg NA NA no no no no up no Synthesis and degradation of ketone bodies Tryptophan metabolism 0.673043478 0.681818182 0.702702703 kegg kegg NA NA no no no no up no Tyrosine metabolism Tryptophan metabolism 0.824347826 0.785573123 0.628571429 kegg kegg NA NA no no no no up no Ubiquinone and other terpenoid-quinone biosynthesis Tryptophan metabolism 0.867826087 0.806324111 0.551093951 kegg kegg NA NA no no no no up no "Valine, leucine and isoleucine degradation" Tryptophan metabolism 0.929565217 0.855731225 0.832947233 kegg kegg NA NA no no no no up no Adrenergic signaling in cardiomyocytes Tuberculosis -0.567826087 -0.649209486 -0.620592021 kegg kegg NA NA no no up no no dn AGE-RAGE signaling pathway in diabetic complications Tuberculosis 0.426086957 0.548418972 0 kegg kegg NA NA no no no no no dn "Alanine, aspartate and glutamate metabolism" Tuberculosis 0.480869565 0.486166008 0.491891892 kegg kegg NA NA no no no no no dn Aldosterone synthesis and secretion Tuberculosis -0.566956522 -0.827075099 -0.60952381 kegg kegg NA NA no up up no no dn alpha-Linolenic acid metabolism Tuberculosis 0 0 0.453024453 kegg kegg NA NA no no no no no dn Alzheimer disease Tuberculosis -0.533043478 -0.564229249 0 kegg kegg NA NA no no no no no dn Aminoacyl-tRNA biosynthesis Tuberculosis 0 -0.414031621 0 kegg kegg NA NA no no no no no dn Amoebiasis Tuberculosis 0 0.486166008 0.47979408 kegg kegg NA NA no no no no no dn Amphetamine addiction Tuberculosis -0.665217391 -0.773715415 -0.466924067 kegg kegg NA NA no no no no no dn AMPK signaling pathway Tuberculosis 0 -0.712450593 0 kegg kegg NA NA no no no no no dn Amyotrophic lateral sclerosis Tuberculosis -0.566956522 -0.618577075 0 kegg kegg NA NA no no no no no dn Antifolate resistance Tuberculosis 0 -0.595849802 0 kegg kegg NA NA no no no no no dn Antigen processing and presentation Tuberculosis 0 0.468379447 0.488288288 kegg kegg NA NA no no no no no dn Apelin signaling pathway Tuberculosis -0.637391304 -0.475296443 0 kegg kegg NA NA no no no no no dn Apoptosis Tuberculosis 0.504347826 0.690711462 0.67001287 kegg kegg NA NA no no no no no dn Arginine and proline metabolism Tuberculosis 0 0.622529644 0.438867439 kegg kegg NA NA no up no no no dn Arginine biosynthesis Tuberculosis 0.532173913 0.515810277 0.541827542 kegg kegg NA NA no no no no no dn Autophagy - other Tuberculosis -0.415652174 0 -0.436808237 kegg kegg NA NA no no no no no dn B cell receptor signaling pathway Tuberculosis 0 0.557312253 0 kegg kegg NA NA no no no no no dn Bacterial invasion of epithelial cells Tuberculosis 0 0 0.453281853 kegg kegg NA NA no no no no no dn Basal transcription factors Tuberculosis 0 -0.611660079 -0.525868726 kegg kegg NA NA no no no no no dn Base excision repair Tuberculosis 0 -0.599802372 0 kegg kegg NA NA no no no no no dn beta-Alanine metabolism Tuberculosis 0.492173913 0 0.487773488 kegg kegg NA NA no no no no no dn Bile secretion Tuberculosis -0.448695652 -0.440711462 0 kegg kegg NA NA no no no no no dn Biosynthesis of amino acids Tuberculosis 0.564347826 0.808300395 0.815701416 kegg kegg NA NA no no no no no dn Biosynthesis of cofactors Tuberculosis 0 -0.637351779 0 kegg kegg NA NA no no no no no dn C-type lectin receptor signaling pathway Tuberculosis 0 0.567193676 0 kegg kegg NA NA no no no no no dn Calcium signaling pathway Tuberculosis -0.406956522 -0.589920949 -0.619305019 kegg kegg NA NA no up up no no dn cAMP signaling pathway Tuberculosis -0.506956522 0 0 yes kegg kegg NA NA no up up no no dn Carbon metabolism Tuberculosis 0.440869565 0.619565217 0.845817246 kegg kegg NA NA no no no no no dn Cardiac muscle contraction Tuberculosis -0.46173913 -0.574110672 0 kegg kegg NA NA no no up no no dn Cell adhesion molecules Tuberculosis 0.496521739 0.759881423 0.415958816 kegg kegg NA NA no no no no no dn Cell cycle Tuberculosis -0.413043478 -0.791501976 -0.597425997 kegg kegg NA NA no no no no no dn Cellular senescence Tuberculosis 0 0.633399209 0 kegg kegg NA NA no no no no no dn cGMP-PKG signaling pathway Tuberculosis 0 0.846837945 0.467953668 kegg kegg NA NA no no no no no dn Chemokine signaling pathway Tuberculosis 0 0.515810277 0 kegg kegg NA NA no no no no no dn Cholesterol metabolism Tuberculosis 0 0.687747036 0.473101673 yes kegg kegg NA NA no no up no no dn Circadian entrainment Tuberculosis -0.452173913 0 0 kegg kegg NA NA no up up no no dn Circadian rhythm Tuberculosis -0.52173913 -0.779644269 -0.689317889 kegg kegg NA NA no no no no no dn Clostridium Tuberculosis 0 0.415672633 0 Genus kegg 0.925 NA no no no no no dn Cocaine addiction Tuberculosis -0.516521739 -0.694664032 -0.464864865 kegg kegg NA NA no no no no no dn Complement and coagulation cascades Tuberculosis 0.467826087 0.774703557 0.745688546 kegg kegg NA NA no no no no no dn Cortisol synthesis and secretion Tuberculosis -0.57826087 -0.757905138 -0.531274131 kegg kegg NA NA no no up no no dn Cushing syndrome Tuberculosis -0.642608696 -0.869565217 -0.689317889 kegg kegg NA NA no no up no no dn DNA replication Tuberculosis 0 -0.568181818 -0.451737452 kegg kegg NA NA no no no no no dn Dopaminergic synapse Tuberculosis -0.652173913 -0.540513834 -0.528442728 kegg kegg NA NA no up no no no dn EGFR tyrosine kinase inhibitor resistance Tuberculosis -0.550434783 -0.455533597 0 kegg kegg NA NA no no no no no dn Endocrine and other factor-regulated calcium reabsorption Tuberculosis -0.406086957 -0.750988142 0 kegg kegg NA NA no no no no no dn Endocrine resistance Tuberculosis -0.469565217 -0.661067194 0 kegg kegg NA NA no no no no no dn Endocytosis Tuberculosis 0.42173913 0.767786561 0 kegg kegg NA NA no no no no no dn Epithelial cell signaling in Helicobacter pylori infection Tuberculosis 0 0.711462451 0 kegg kegg NA NA no no no no no dn Estrogen signaling pathway Tuberculosis 0 -0.441699605 0 kegg kegg NA NA no no no no no dn Ether lipid metabolism Tuberculosis -0.490434783 -0.546442688 0 kegg kegg NA NA no no no no no dn Fanconi anemia pathway Tuberculosis 0 -0.579051383 -0.419305019 kegg kegg NA NA no no no no no dn Fat digestion and absorption Tuberculosis 0.500869565 0.681818182 0.645817246 yes kegg kegg NA NA no up up no no dn Fatty acid biosynthesis Tuberculosis 0.497391304 0.557312253 0 kegg kegg NA NA no no no no no dn Fatty acid degradation Tuberculosis 0.528695652 0.499011858 0.481081081 kegg kegg NA NA no no no no no dn Fatty acid elongation Tuberculosis 0.543478261 0 0.410553411 kegg kegg NA NA no no no no no dn Fatty acid metabolism Tuberculosis 0.67826087 0.600790514 0.548777349 kegg kegg NA NA no no no no no dn Fc epsilon RI signaling pathway Tuberculosis 0 0.669960474 0.431402831 kegg kegg NA NA no no no no no dn Fc gamma R-mediated phagocytosis Tuberculosis 0.729565217 0.902173913 0.818790219 kegg kegg NA NA no no no no no dn Fructose and mannose metabolism Tuberculosis 0 0 0.412612613 kegg kegg NA NA no no no no no dn GABAergic synapse Tuberculosis 0.417391304 0 0 kegg kegg NA NA no up up no no dn Galactose metabolism Tuberculosis 0.559130435 0 0 kegg kegg NA NA no no no no no dn Gemmiger Tuberculosis -0.41617744 0 0 butyrate-producing Genus kegg 0.595 NA no no no no no dn Glucagon signaling pathway Tuberculosis -0.703478261 -0.851778656 -0.726383526 kegg kegg NA NA no no no no no dn Glutathione metabolism Tuberculosis 0 -0.614624506 0 kegg kegg NA NA no no no no no dn "Glycine, serine and threonine metabolism" Tuberculosis 0 -0.602766798 0 kegg kegg NA NA no up no no no dn Glycolysis / Gluconeogenesis Tuberculosis 0 0 0.570656371 kegg kegg NA NA no no no no no dn Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Tuberculosis 0.447826087 0 0 kegg kegg NA NA no no no no no dn Glycosaminoglycan biosynthesis - keratan sulfate Tuberculosis 0 0 -0.523294723 kegg kegg NA NA no no no no no dn Glycosaminoglycan degradation Tuberculosis 0.414782609 0.769762846 0 kegg kegg NA NA no no up no no dn Glycosphingolipid biosynthesis - lacto and neolacto series Tuberculosis 0 0 -0.44041184 kegg kegg NA NA no no no no no dn Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Tuberculosis 0 -0.58201581 -0.47027027 kegg kegg NA NA no no no no no dn Glyoxylate and dicarboxylate metabolism Tuberculosis 0.637391304 0.568181818 0.574002574 kegg kegg NA NA no no no no no dn GnRH signaling pathway Tuberculosis -0.449565217 -0.670948617 -0.431917632 kegg kegg NA NA no no no no no dn Hedgehog signaling pathway Tuberculosis 0 -0.616600791 -0.507850708 kegg kegg NA NA no no no no no dn Hematopoietic cell lineage Tuberculosis 0.46 0 0.455855856 kegg kegg NA NA no no no no no dn HIF-1 signaling pathway Tuberculosis -0.445217391 0 0 kegg kegg NA NA no no no no no dn Hippo signaling pathway - multiple species Tuberculosis 0.435652174 0.501976285 0 kegg kegg NA NA no no no no no dn Histidine metabolism Tuberculosis 0.424347826 0 0.4996139 kegg kegg NA NA no no no no no dn Homologous recombination Tuberculosis 0 -0.45256917 -0.400772201 kegg kegg NA NA no no no no no dn Huntington disease Tuberculosis -0.513043478 -0.589920949 0 kegg kegg NA NA no no no no no dn IL-17 signaling pathway Tuberculosis 0.417391304 0.848814229 0.602831403 kegg kegg NA NA no no no no no dn Inflammatory mediator regulation of TRP channels Tuberculosis -0.51826087 -0.652173913 -0.53976834 kegg kegg NA NA no no no no no dn Insulin resistance Tuberculosis 0 0 -0.426769627 kegg kegg NA NA no no no no no dn Insulin secretion Tuberculosis -0.493043478 -0.774703557 -0.535649936 yes kegg kegg NA NA no up up no no dn Insulin signaling pathway Tuberculosis -0.587826087 -0.435770751 0 kegg kegg NA NA no no no no no dn Intestinal immune network for IgA production Tuberculosis 0 0 0.428828829 kegg kegg NA NA no no no no no dn Leukocyte transendothelial migration Tuberculosis 0 0 0.637323037 kegg kegg NA NA no no no no no dn Lysine degradation Tuberculosis 0 -0.580039526 -0.528957529 kegg kegg NA NA no no no no no dn Lysosome Tuberculosis 0.600869565 0.928853755 0.787129987 kegg kegg NA NA no no no no no dn Mannose type O-glycan biosynthesis Tuberculosis 0 -0.488142292 -0.571943372 kegg kegg NA NA no no no no no dn Melanogenesis Tuberculosis -0.506956522 -0.672924901 -0.568082368 kegg kegg NA NA no no no no no dn Mineral absorption Tuberculosis -0.497391304 -0.473320158 0 kegg kegg NA NA no no no no no dn Mismatch repair Tuberculosis 0 -0.437747036 0 kegg kegg NA NA no no no no no dn Mitophagy - animal Tuberculosis -0.708695652 -0.617588933 0 kegg kegg NA NA no no no no no dn Morphine addiction Tuberculosis -0.464347826 -0.654150198 0 kegg kegg NA NA no up up no no dn mRNA surveillance pathway Tuberculosis -0.513043478 -0.734189723 -0.746718147 kegg kegg NA NA no no no no no dn mTOR signaling pathway Tuberculosis -0.603478261 -0.438735178 0 kegg kegg NA NA no no no no no dn N-Glycan biosynthesis Tuberculosis -0.445217391 -0.611660079 -0.459459459 kegg kegg NA NA no no no no no dn Natural killer cell mediated cytotoxicity Tuberculosis 0.405217391 0.693675889 0 kegg kegg NA NA no no no no no dn Necroptosis Tuberculosis -0.452173913 0 0 kegg kegg NA NA no no no no no dn Neuroactive ligand-receptor interaction Tuberculosis 0 0.904150198 0.761132561 kegg kegg NA NA up up up no no dn Neutrophil extracellular trap formation Tuberculosis 0.729565217 0.869565217 0.811325611 kegg kegg NA NA no no no no no dn Nicotinate and nicotinamide metabolism Tuberculosis 0.574782609 0.640316206 0.546460746 kegg kegg NA NA no no no no no dn Nicotine addiction Tuberculosis 0 -0.503952569 0 kegg kegg NA NA no up up no no dn Nitrogen metabolism Tuberculosis 0 0.446640316 0 kegg kegg NA NA no no no no no dn NOD-like receptor signaling pathway Tuberculosis 0.591304348 0.635375494 0 kegg kegg NA NA no no no no no dn Non-alcoholic fatty liver disease Tuberculosis -0.56173913 -0.541501976 -0.425740026 kegg kegg NA NA no no no no no dn Nucleotide excision repair Tuberculosis 0 -0.591897233 0 kegg kegg NA NA no no no no no dn Olfactory transduction Tuberculosis 0 0.777667984 0.738481338 kegg kegg NA NA no no no no no dn One carbon pool by folate Tuberculosis 0 -0.590909091 -0.416988417 kegg kegg NA NA no no no no no dn Oocyte meiosis Tuberculosis -0.456521739 0 0 kegg kegg NA NA no no no no no dn Osteoclast differentiation Tuberculosis 0.559130435 0.796442688 0.59047619 kegg kegg NA NA no no no no no dn Other types of O-glycan biosynthesis Tuberculosis -0.468695652 -0.647233202 -0.496267696 kegg kegg NA NA no no no no no dn Ovarian steroidogenesis Tuberculosis 0 -0.51284585 0 kegg kegg NA NA no up up no no dn Oxidative phosphorylation Tuberculosis -0.487826087 -0.540513834 0 kegg kegg NA NA no no no no no dn Oxytocin signaling pathway Tuberculosis 0 0 0.503474903 kegg kegg NA NA no no no no no dn p53 signaling pathway Tuberculosis 0 -0.431818182 -0.550579151 kegg kegg NA NA no no no no no dn Pancreatic secretion Tuberculosis -0.462608696 -0.558300395 0 kegg kegg NA NA no no no no no dn Pantothenate and CoA biosynthesis Tuberculosis 0.536521739 0.708498024 0.610553411 kegg kegg NA NA no no dn no no dn "Parathyroid hormone synthesis, secretion and action" Tuberculosis -0.771304348 -0.555335968 -0.41956242 kegg kegg NA NA no no no no no dn Parkinson disease Tuberculosis -0.7 -0.56916996 -0.405662806 kegg kegg NA NA no no no no no dn Pathogenic Escherichia coli infection Tuberculosis 0.487826087 0.786561265 0.67001287 kegg kegg NA NA no no no no no dn Pathways of neurodegeneration - multiple diseases Tuberculosis -0.699130435 -0.600790514 -0.411325611 kegg kegg NA NA no no no no no dn Pentose and glucuronate interconversions Tuberculosis 0 -0.435770751 0 kegg kegg NA NA no no no no no dn Pentose phosphate pathway Tuberculosis 0.555652174 0.898221344 0.762934363 kegg kegg NA NA no no no no no dn Peroxisome Tuberculosis 0.568695652 0.633399209 0.470785071 kegg kegg NA NA no no no no no dn Pertussis Tuberculosis 0.676521739 0.91798419 0.82960103 kegg kegg NA NA no no dn no no dn Phagosome Tuberculosis 0.62 0.836956522 0.628314028 kegg kegg NA NA no no no no no dn Phosphatidylinositol signaling system Tuberculosis 0 -0.448616601 -0.546718147 kegg kegg NA NA no no no no no dn PI3K-Akt signaling pathway Tuberculosis -0.482608696 0 0 yes kegg kegg NA NA no up up no no dn Porphyrin and chlorophyll metabolism Tuberculosis 0 -0.564229249 0 kegg kegg NA NA no no no no no dn PPAR signaling pathway Tuberculosis 0 0.665019763 0.455083655 kegg kegg NA NA no no no no no dn Primary bile acid biosynthesis Tuberculosis 0 0 0.603346203 kegg kegg NA NA no no no no no dn Prion disease Tuberculosis -0.511304348 -0.502964427 0 kegg kegg NA NA no no no no no dn Prolactin signaling pathway Tuberculosis 0 0.475296443 0 kegg kegg NA NA no no no no no dn Protein digestion and absorption Tuberculosis 0.674782609 0.696640316 0 yes kegg kegg NA NA no up up no no dn Protein export Tuberculosis -0.6 0 -0.496010296 kegg kegg NA NA no no no no no dn Protein processing in endoplasmic reticulum Tuberculosis -0.66173913 -0.703557312 -0.413899614 kegg kegg NA NA no no no no no dn Proximal tubule bicarbonate reclamation Tuberculosis 0 -0.499011858 0 kegg kegg NA NA no no no no no dn Purine metabolism Tuberculosis 0 -0.72826087 0 kegg kegg NA NA no no no no no dn Pyrimidine metabolism Tuberculosis 0 -0.498023715 0 kegg kegg NA NA no no no no no dn Pyruvate metabolism Tuberculosis 0 -0.441699605 0 kegg kegg NA NA no no no no no dn Ras signaling pathway Tuberculosis 0 0 -0.46048906 yes kegg kegg NA NA no up up no no dn Regulation of lipolysis in adipocytes Tuberculosis -0.496521739 -0.564229249 0 kegg kegg NA NA no no no no no dn Relaxin signaling pathway Tuberculosis -0.566086957 0 0 kegg kegg NA NA no no no no no dn Renin secretion Tuberculosis -0.462608696 -0.542490119 0 kegg kegg NA NA no no no no no dn Renin-angiotensin system Tuberculosis 0.523478261 0.914031621 0.57039897 kegg kegg NA NA no no no no no dn Retrograde endocannabinoid signaling Tuberculosis 0 -0.504940711 0 kegg kegg NA NA no no up no no dn Ribosome Tuberculosis -0.715652174 -0.480237154 0 kegg kegg NA NA no no no no no dn Ribosome biogenesis in eukaryotes Tuberculosis -0.41826087 -0.722332016 -0.551351351 kegg kegg NA NA no no no no no dn RNA degradation Tuberculosis -0.432173913 -0.663043478 -0.563963964 kegg kegg NA NA no no no no no dn RNA polymerase Tuberculosis -0.508695652 -0.792490119 -0.503732304 kegg kegg NA NA no no no no no dn Salmonella infection Tuberculosis 0.503478261 0.776679842 0.697554698 kegg kegg NA NA no no no no no dn Selenocompound metabolism Tuberculosis 0 -0.459486166 0 kegg kegg NA NA no no no no no dn Shigellosis Tuberculosis -0.605217391 0 0 kegg kegg NA NA no no no no no dn Signaling pathways regulating pluripotency of stem cells Tuberculosis 0 -0.445652174 -0.486229086 kegg kegg NA NA no no no no no dn Sphingolipid metabolism Tuberculosis 0.453043478 0 0.451737452 kegg kegg NA NA no no no no no dn Sphingolipid signaling pathway Tuberculosis 0 0.612648221 0 kegg kegg NA NA no no no no no dn Spinocerebellar ataxia Tuberculosis -0.425217391 -0.624505929 0 kegg kegg NA NA no no no no no dn Spliceosome Tuberculosis 0 -0.469367589 -0.51969112 kegg kegg NA NA no no no no no dn Staphylococcus aureus infection Tuberculosis 0.92173913 0.963438735 0.927155727 kegg kegg NA NA up no no no no dn Starch and sucrose metabolism Tuberculosis 0.428695652 0.604743083 0.584041184 kegg kegg NA NA no no no no no dn Steroid biosynthesis Tuberculosis -0.42 0 0 kegg kegg NA NA no no no no no dn Synaptic vesicle cycle Tuberculosis 0 0.805335968 0.581209781 kegg kegg NA NA no up up no no dn Synthesis and degradation of ketone bodies Tuberculosis 0 -0.446640316 0 kegg kegg NA NA no no no no no dn Taste transduction Tuberculosis 0 -0.586956522 -0.400514801 kegg kegg NA NA no no up no no dn Taurine and hypotaurine metabolism Tuberculosis 0 0 -0.445302445 kegg kegg NA NA no no no no no dn Th1 and Th2 cell differentiation Tuberculosis 0 0.416007905 0 kegg kegg NA NA no no no no no dn Thermogenesis Tuberculosis -0.539130435 -0.572134387 0 kegg kegg NA NA no no no no no dn Thyroid hormone synthesis Tuberculosis -0.533913043 -0.708498024 0 kegg kegg NA NA no no no no no dn Tight junction Tuberculosis 0 0 0.519176319 kegg kegg NA NA no no no no no dn Toll-like receptor signaling pathway Tuberculosis 0 0.625494071 0 yes kegg kegg NA NA no no no no no dn Toxoplasmosis Tuberculosis 0.566086957 0.691699605 0.563191763 kegg kegg NA NA no no no no no dn Type I diabetes mellitus Tuberculosis 0.476521739 0.694664032 0 kegg kegg NA NA no no no no no dn Ubiquitin mediated proteolysis Tuberculosis -0.726086957 -0.709486166 0 kegg kegg NA NA no no no no no dn Various types of N-glycan biosynthesis Tuberculosis -0.524347826 -0.461462451 0 kegg kegg NA NA no no no no no dn Vascular smooth muscle contraction Tuberculosis -0.622608696 0 0 kegg kegg NA NA no no no no no dn Vasopressin-regulated water reabsorption Tuberculosis -0.497391304 -0.660079051 0 kegg kegg NA NA no no no no no dn Wnt signaling pathway Tuberculosis 0 -0.698616601 -0.571171171 kegg kegg NA NA no no no no no dn Yersinia infection Tuberculosis 0.483478261 0.791501976 0.473359073 kegg kegg NA NA no no no no no dn 11-HETE+blood TUDCA+blood 0 0.573131914 0 yes serum_ARA serum_bileacids 0.464 0.0282 no no no no no dn 12-ketoDCA+stool TUDCA+blood -0.628970902 0 0 yes stool_bileacids serum_bileacids 0.505 0.0282 no no no no no dn 14:0/16:0-PC+blood TUDCA+blood -0.450602565 0 0 yes serum_phospholipids serum_bileacids 0.0358 0.0282 no up no no no dn 16:0/14:0-PC+blood TUDCA+blood -0.462460527 0 0 yes serum_phospholipids serum_bileacids 0.0206 0.0282 no up up no no dn 16:0/16:0-PC+blood TUDCA+blood -0.604756074 0 0 yes serum_phospholipids serum_bileacids 0.00079 0.0282 no up up no no dn 16:0/16:1-PI+blood TUDCA+blood 0 0.55704523 0 yes serum_phospholipids serum_bileacids 0.262 0.0282 no no no no no dn 16:0/18:1-PC+blood TUDCA+blood -0.549418917 0 0 yes serum_phospholipids serum_bileacids 6.15E-07 0.0282 up up up no no dn 16:0/18:1-PE+blood TUDCA+blood 0.470365835 0 0 yes serum_phospholipids serum_bileacids 0.000107 0.0282 up up no no no dn 16:0/18:2-PC+blood TUDCA+blood -0.468389508 0 0 yes serum_phospholipids serum_bileacids 3.24E-06 0.0282 no up up no no dn 16:0/20:4-PC+blood TUDCA+blood -0.606732401 0 0 yes serum_phospholipids serum_bileacids 0.0262 0.0282 no up no no no dn 16:0/20:4-PI+blood TUDCA+blood 0 0 -0.414208319 yes serum_phospholipids serum_bileacids 0.558 0.0282 no no no no no dn 16:1/16:0-PC+blood TUDCA+blood -0.480247471 0 0 yes serum_phospholipids serum_bileacids 0.0215 0.0282 no up up no no dn 16:1/16:1-PC+blood TUDCA+blood -0.490129106 0 0 yes serum_phospholipids serum_bileacids 0.0177 0.0282 no no up no no dn 18:0/16:0-PC+blood TUDCA+blood -0.590921785 0 0 yes serum_phospholipids serum_bileacids 9.64E-07 0.0282 up up up no no dn 18:0/18:1-PE+blood TUDCA+blood 0 0.493931731 0 yes serum_phospholipids serum_bileacids 0.00716 0.0282 up up no no no dn 18:0/18:2-PI+blood TUDCA+blood 0.480247471 0 -0.424005625 yes serum_phospholipids serum_bileacids 0.179 0.0282 no no no no no dn 18:0/20:4-PC+blood TUDCA+blood -0.606732401 0 0 yes serum_phospholipids serum_bileacids 0.454 0.0282 no no no no no dn 18:0/22:6-PI+blood TUDCA+blood 0 0 -0.41094255 yes serum_phospholipids serum_bileacids 0.425 0.0282 no no no no no dn 18:1/16:0-PC+blood TUDCA+blood -0.531631974 0 0 yes serum_phospholipids serum_bileacids 2.43E-05 0.0282 no up up no no dn 18:1/18:2-PE+blood TUDCA+blood 0.496058087 0 0 yes serum_phospholipids serum_bileacids 0.000293 0.0282 up up no no no dn 18:1/20:4-PI+blood TUDCA+blood 0 -0.544696937 0 yes serum_phospholipids serum_bileacids 0.192 0.0282 no no no no no dn 18:3-LPC+blood TUDCA+blood 0.519774011 0 0 yes serum_phospholipids serum_bileacids 0.147 0.0282 no no no no no dn 18:3/18:2-PC+blood TUDCA+blood 0.466413181 0 0 yes serum_phospholipids serum_bileacids 0.0394 0.0282 no no up no no dn 20-HDOHE+blood TUDCA+blood -0.444453938 0 0 yes serum_ARA serum_bileacids 0.205 0.0282 no no no no no dn 20:0-LPC+blood TUDCA+blood 0.476294817 0 0 yes serum_phospholipids serum_bileacids 0.199 0.0282 no no no no no dn 20:0-LPE+blood TUDCA+blood 0.519774011 0 0 yes serum_phospholipids serum_bileacids 0.0615 0.0282 no no up no no dn 20:2/18:1-PE+blood TUDCA+blood 0.56720586 0 0 yes serum_phospholipids serum_bileacids 0.00208 0.0282 up up no no no dn 20:3/16:0-PC+blood TUDCA+blood -0.606732401 0 0 yes serum_phospholipids serum_bileacids 0.00405 0.0282 no up up no no dn 20:3n6+blood TUDCA+blood 0.503963395 0 0 yes serum_fattyacid serum_bileacids 0.0884 0.0282 up no no no no dn 20:4-LPE+blood TUDCA+blood 0 -0.485699536 0 yes serum_phospholipids serum_bileacids 0.552 0.0282 no no no no no dn 20:4/16:0-PE+blood TUDCA+blood 0.500010741 0 0 yes serum_phospholipids serum_bileacids 0.00529 0.0282 no up up no no dn 20:4n6+blood TUDCA+blood -0.482223798 0 0 yes serum_fattyacid serum_bileacids 0.133 0.0282 no no no no no dn ACA+blood TUDCA+blood -0.527912176 0 0 yes serum_bileacids serum_bileacids 0.338 0.0282 no no no no no dn Alcoholism TUDCA+blood 0 -0.518776512 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Alzheimer disease TUDCA+blood 0 0.51539686 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Amphetamine addiction TUDCA+blood 0 0.561022156 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Amyotrophic lateral sclerosis TUDCA+blood 0 0.650582922 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Anaerostipes TUDCA+blood 0 0 0.457788218 butyrate-producing yes Genus serum_bileacids 0.568 0.0282 no no no no no dn Biosynthesis of amino acids TUDCA+blood 0 -0.682689612 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Bladder cancer TUDCA+blood 0 -0.498498602 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Butyric acid+stool TUDCA+blood -0.620235195 0 0 yes yes stool_scfa serum_bileacids 0.102 0.0282 dn no no no no dn C-type lectin receptor signaling pathway TUDCA+blood 0 0 -0.413223022 yes kegg serum_bileacids NA 0.0282 no no no no no dn CA+stool TUDCA+blood 0.620235195 0 0 yes stool_bileacids serum_bileacids 0.827 0.0282 no no no no no dn Calcium signaling pathway TUDCA+blood 0 0 -0.4843022 yes kegg serum_bileacids NA 0.0282 no up up no no dn capric acid C6+blood TUDCA+blood 0 0 0.492586766 yes serum_scfa serum_bileacids 0.433 0.0282 no no no no no dn CDCA+blood TUDCA+blood 0 0.646227348 0 yes serum_bileacids serum_bileacids 0.506 0.0282 no no no no no dn CDCA+stool TUDCA+blood 0.628970902 0 0 yes stool_bileacids serum_bileacids 0.663 0.0282 no no no no no dn Cell cycle TUDCA+blood 0 0.525535815 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Cellular senescence TUDCA+blood 0 -0.569471285 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn cGMP-PKG signaling pathway TUDCA+blood 0 -0.613406755 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Clostridium TUDCA+blood 0.595849692 0 0 yes Genus serum_bileacids 0.925 0.0282 no no no no no dn Cysteine+blood TUDCA+blood 0 -0.532348644 0 yes yes serum_aminoacids serum_bileacids 1.81E-07 0.0282 dn up up no no dn d18:1-18:0-SM+blood TUDCA+blood -0.462460527 0 0 yes serum_phospholipids serum_bileacids 0.97 0.0282 no no no no no dn DCA+stool TUDCA+blood -0.620235195 0 0 yes stool_bileacids serum_bileacids 0.195 0.0282 no no no no no dn Endocytosis TUDCA+blood 0 -0.557642504 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Epithelial cell signaling in Helicobacter pylori infection TUDCA+blood 0 -0.564401808 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Fc gamma R-mediated phagocytosis TUDCA+blood 0 -0.528915466 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn GABAergic synapse TUDCA+blood 0 -0.594818671 0 yes kegg serum_bileacids NA 0.0282 no up up no no dn GCA+blood TUDCA+blood 0 0.654459544 0 yes yes serum_bileacids serum_bileacids 0.16 0.0282 no no no no no dn GCDCA+blood TUDCA+blood 0 0.798522966 0 yes serum_bileacids serum_bileacids 0.31 0.0282 no no no no no dn Gemmiger TUDCA+blood -0.604756074 0 0 butyrate-producing yes Genus serum_bileacids 0.595 0.0282 no no no no no dn Glycolysis / Gluconeogenesis TUDCA+blood 0 0 0.439727122 yes kegg serum_bileacids NA 0.0282 no no no no no dn GUDCA+blood TUDCA+blood 0.575111169 0.791662803 0 yes serum_bileacids serum_bileacids 0.0766 0.0282 no no dn no no dn HCA+blood TUDCA+blood 0 0.512591464 0 yes serum_bileacids serum_bileacids 0.544 0.0282 no no no no no dn HDCA+stool TUDCA+blood -0.620235195 0 0 yes stool_bileacids serum_bileacids 0.176 0.0282 no no no no no dn Hepatitis B TUDCA+blood 0 0 -0.452979172 yes kegg serum_bileacids NA 0.0282 no no no no no dn Hepatitis C TUDCA+blood 0 0 -0.480688005 yes kegg serum_bileacids NA 0.0282 no no no no no dn Human papillomavirus infection TUDCA+blood 0 -0.564401808 -0.401175703 yes kegg serum_bileacids NA 0.0282 no no no no no dn Huntington disease TUDCA+blood 0 0.51539686 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn iso-LCA+blood TUDCA+blood -0.527912176 0 0 yes serum_bileacids serum_bileacids 0.507 0.0282 no no no no no dn iso-LCA+stool TUDCA+blood -0.625462792 0 0 yes stool_bileacids serum_bileacids 0.72 0.0282 no no no no no dn isovaleric acid iso-C5+blood TUDCA+blood 0 0 -0.476257923 yes serum_scfa serum_bileacids 0.117 0.0282 no no no no no dn L-Aspartic acid+blood TUDCA+blood -0.496058087 0 0 yes yes serum_aminoacids serum_bileacids 0.0226 0.0282 up up no no no dn L-Tyrosine+blood TUDCA+blood 0 0.492559699 0 yes yes serum_aminoacids serum_bileacids 0.00913 0.0282 up up no no no dn LCA+blood TUDCA+blood -0.527912176 0 0 yes serum_bileacids serum_bileacids 0.884 0.0282 no no no no no dn LCA+stool TUDCA+blood -0.628970902 0 0 yes stool_bileacids serum_bileacids 0.314 0.0282 no no no no no dn Lipid and atherosclerosis TUDCA+blood 0 -0.54750355 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Longevity regulating pathway - multiple species TUDCA+blood 0 0 0.401175703 yes kegg serum_bileacids NA 0.0282 no no no no no dn mRNA surveillance pathway TUDCA+blood 0 0.586369543 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Natural killer cell mediated cytotoxicity TUDCA+blood 0 -0.571161111 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Neurotrophin signaling pathway TUDCA+blood 0 0 -0.437317658 yes kegg serum_bileacids NA 0.0282 no no no no no dn Neutrophil extracellular trap formation TUDCA+blood 0 -0.501878254 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Nicotinate and nicotinamide metabolism TUDCA+blood 0 -0.599888149 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn nutriCA+stool TUDCA+blood 0.628970902 0 0 yes stool_bileacids serum_bileacids 0.481 0.0282 no no no no no dn Olfactory transduction TUDCA+blood 0 -0.586369543 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Oxidative phosphorylation TUDCA+blood 0 0.505257906 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Pathogenic Escherichia coli infection TUDCA+blood 0 -0.549193376 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Pathways of neurodegeneration - multiple diseases TUDCA+blood 0 0.508637557 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Pertussis TUDCA+blood 0 -0.517086686 0 yes kegg serum_bileacids NA 0.0282 no no dn no no dn Phagosome TUDCA+blood 0 -0.525535815 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Phenylacetic acid+stool TUDCA+blood 0 -0.62122474 0 yes stool_cometabolism serum_bileacids 0.785 0.0282 no no no no no dn Phospholipase D signaling pathway TUDCA+blood 0 -0.542434073 0 yes kegg serum_bileacids NA 0.0282 no up up no no dn PPAR signaling pathway TUDCA+blood 0 -0.535674769 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Prion disease TUDCA+blood 0 0.561022156 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Prostate cancer TUDCA+blood 0 0 -0.466231223 yes kegg serum_bileacids NA 0.0282 no no no no no dn Protein processing in endoplasmic reticulum TUDCA+blood 0 0.520466337 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn PUFA/UFA+blood TUDCA+blood -0.464436854 0 0 yes serum_fattyacid serum_bileacids 0.000732 0.0282 dn no up no no dn PUFA%+blood TUDCA+blood -0.476294817 0 0 yes serum_fattyacid serum_bileacids 0.0013 0.0282 dn no up no no dn Ribosome biogenesis in eukaryotes TUDCA+blood 0 0.498498602 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn RIG-I-like receptor signaling pathway TUDCA+blood 0 0 -0.416837217 yes kegg serum_bileacids NA 0.0282 no no no no no dn RNA degradation TUDCA+blood 0 0.566091633 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Sarcosine+blood TUDCA+blood 0 0 -0.504561251 yes serum_choline serum_bileacids 5.06E-05 0.0282 up up no no no dn SFA%+blood TUDCA+blood -0.484200125 0 0 yes serum_fattyacid serum_bileacids 0.0236 0.0282 no up no no no dn TCA+blood TUDCA+blood 0.505570557 0.742118422 0.43830895 yes serum_bileacids serum_bileacids 0.339 0.0282 no no no no no dn Thermogenesis TUDCA+blood 0 0.500188428 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn TMAO+blood TUDCA+blood -0.478271144 0 0 yes serum_choline serum_bileacids 0.00706 0.0282 up up no no no dn total_blood_scfa+blood TUDCA+blood 0 0 0.563889381 yes serum_scfa serum_bileacids 0.168 0.0282 no no no no no dn Ubiquitin mediated proteolysis TUDCA+blood 0 0.540744247 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn Viral carcinogenesis TUDCA+blood 0 -0.552573027 -0.414427753 yes kegg serum_bileacids NA 0.0282 no no no no no dn Wnt signaling pathway TUDCA+blood 0 0.569471285 0 yes kegg serum_bileacids NA 0.0282 no no no no no dn 3-(3-Hydroxyphenyl)propanoic acid+stool TUDCA+stool 0 -0.590785249 0 stool_cometabolism stool_bileacids 0.33 0.241 no no no no no no 5-Hydroxytryptamine+stool TUDCA+stool -0.641327881 0 0 stool_cometabolism stool_bileacids 0.00862 0.241 dn dn no no no no Butyricicoccus TUDCA+stool 0 0.703597545 0 butyrate-producing Genus stool_bileacids 0.852 0.241 no no no no no no CA+stool TUDCA+stool 0 0 -0.427038114 stool_bileacids stool_bileacids 0.827 0.241 no no no no no no Central carbon metabolism in cancer TUDCA+stool 0 -0.768634 0 kegg stool_bileacids NA 0.241 no no no no no no Coprococcus TUDCA+stool 0 0.611587546 0 butyrate-producing Genus stool_bileacids 0.612 0.241 no no no no no no GCA+stool TUDCA+stool -0.618386071 0 0 stool_bileacids stool_bileacids 0.0809 0.241 no no no no no no GCDCA+stool TUDCA+stool -0.745608838 0 0 yes stool_bileacids stool_bileacids 0.0471 0.241 no dn no no no no GDCA+stool TUDCA+stool -0.502893768 0 0 stool_bileacids stool_bileacids 0.656 0.241 no no no no no no GUDCA+stool TUDCA+stool 0 0.603985292 0 yes stool_bileacids stool_bileacids 0.0085 0.241 no dn no no no no L-Phenylalanine+stool TUDCA+stool 0 0 0.487744512 stool_cometabolism stool_bileacids 0.398 0.241 no no no no no no L-Tyrosine+stool TUDCA+stool 0 0.682315358 0.494024484 stool_cometabolism stool_bileacids 0.44 0.241 no no no no no no Legionellosis TUDCA+stool 0 -0.663341671 0 kegg stool_bileacids NA 0.241 no no no no no no nutriCA+stool TUDCA+stool 0 0 -0.539030952 stool_bileacids stool_bileacids 0.481 0.241 no no no no no no Propionic acid+stool TUDCA+stool 0.528704449 0 0 yes stool_scfa stool_bileacids 0.0436 0.241 dn no up no no no Relaxin signaling pathway TUDCA+stool 0 0.610695507 0 kegg stool_bileacids NA 0.241 no no no no no no T-¦Á-MCA+stool TUDCA+stool 0 0.906522023 0 stool_bileacids stool_bileacids 0.48 0.241 no no no no no no 11-HETE+blood TXB2+blood -0.592394158 -0.785626534 -0.419042409 yes serum_ARA serum_ARA 0.464 0.0644 no no no dn no no 14:0/16:0-PC+blood TXB2+blood 0 -0.579976497 0 yes serum_phospholipids serum_ARA 0.0358 0.0644 no up no dn no no 14:0/18:0-PC+blood TXB2+blood 0 -0.790421533 0 yes serum_phospholipids serum_ARA 0.00289 0.0644 up up no dn no no 16:0-LPC+blood TXB2+blood 0.474398128 0 0 yes serum_phospholipids serum_ARA 0.00456 0.0644 up up no dn no no 16:0/16:0-PI+blood TXB2+blood 0 -0.631335107 0 yes serum_phospholipids serum_ARA 0.358 0.0644 no no no dn no no 16:0/16:1-PC+blood TXB2+blood 0 -0.787916235 0 yes serum_phospholipids serum_ARA 0.00283 0.0644 up up no dn no no 16:0/16:1-PI+blood TXB2+blood 0 -0.75534736 0 yes serum_phospholipids serum_ARA 0.262 0.0644 no no no dn no no 16:0/18:1-PE+blood TXB2+blood 0 -0.584987093 0 yes serum_phospholipids serum_ARA 0.000107 0.0644 up up no dn no no 16:0/18:2-PI+blood TXB2+blood 0 -0.587492391 0 yes serum_phospholipids serum_ARA 0.269 0.0644 no no no dn no no 16:0/20:4-PE+blood TXB2+blood 0 0 -0.476028095 yes serum_phospholipids serum_ARA 0.00139 0.0644 up up no dn no no 16:0/22:0-PE+blood TXB2+blood 0 0.572460603 0 yes serum_phospholipids serum_ARA 0.00839 0.0644 dn no up dn no no 16:0/22:6-PC+blood TXB2+blood 0 0.661398684 0 yes serum_phospholipids serum_ARA 4.53E-05 0.0644 no up up dn no no 16:1/16:0-PC+blood TXB2+blood 0 0.558681464 0 yes serum_phospholipids serum_ARA 0.0215 0.0644 no up up dn no no 16:1/18:1-PG+blood TXB2+blood 0 0 -0.430480083 yes serum_phospholipids serum_ARA 3.21E-05 0.0644 no up up dn no no 18:0/18:0-PE+blood TXB2+blood 0 -0.598766233 0 yes serum_phospholipids serum_ARA 0.00896 0.0644 up up no dn no no 18:0/18:1-PE+blood TXB2+blood 0 -0.598766233 0 yes serum_phospholipids serum_ARA 0.00716 0.0644 up up no dn no no 18:0/18:1-PI+blood TXB2+blood 0 -0.729041731 0 yes serum_phospholipids serum_ARA 0.599 0.0644 no no no dn no no 18:0/20:3-PC+blood TXB2+blood 0 -0.518596695 0 yes serum_phospholipids serum_ARA 0.0682 0.0644 no up no dn no no 18:0/20:4-PC+blood TXB2+blood 0 0.655135439 0 yes serum_phospholipids serum_ARA 0.454 0.0644 no no no dn no no 18:0/20:5-PC+blood TXB2+blood 0 0.812969215 0 yes serum_phospholipids serum_ARA 0.17 0.0644 no no no dn no no 18:0/22:6-PC+blood TXB2+blood 0.475904154 0.592502987 0 yes serum_phospholipids serum_ARA 0.0775 0.0644 no no up dn no no 18:1-LPE+blood TXB2+blood -0.593374167 0 0 yes serum_phospholipids serum_ARA 0.117 0.0644 no no no dn no no 18:1/16:0-PE+blood TXB2+blood 0 -0.564944709 0 yes serum_phospholipids serum_ARA 0.000182 0.0644 up up no dn no no 18:1/16:0-PI+blood TXB2+blood 0 -0.655135439 0 yes serum_phospholipids serum_ARA 0.793 0.0644 no no no dn no no 18:1/16:1-PE+blood TXB2+blood 0 -0.571207954 0 yes serum_phospholipids serum_ARA 0.000184 0.0644 up up no dn no no 18:1/18:0-PE+blood TXB2+blood 0 -0.541144378 0 yes serum_phospholipids serum_ARA 1.39E-06 0.0644 up up no dn no no 18:1/18:0-PI+blood TXB2+blood 0 -0.486027821 0 yes serum_phospholipids serum_ARA 0.0931 0.0644 no no up dn no no 18:1/18:1-PC+blood TXB2+blood 0 -0.538639079 0 yes serum_phospholipids serum_ARA 1.34E-05 0.0644 no up up dn no no 18:1/18:1-PE+blood TXB2+blood 0 -0.519849344 0 yes serum_phospholipids serum_ARA 1.03E-05 0.0644 up up no dn no no 18:1/18:1-PG+blood TXB2+blood 0 -0.541144378 -0.457192451 yes serum_phospholipids serum_ARA 0.00352 0.0644 no up up dn no no 18:1/18:2-PE+blood TXB2+blood 0 -0.53738643 0 yes serum_phospholipids serum_ARA 0.000293 0.0644 up up no dn no no 18:1/18:2-PG+blood TXB2+blood 0 -0.498554311 0 yes serum_phospholipids serum_ARA 5.58E-07 0.0644 no up up dn no no 18:1/20:4-PC+blood TXB2+blood 0 0.787916235 0 yes serum_phospholipids serum_ARA 0.582 0.0644 no no no dn no no 18:2/18:2-PS+blood TXB2+blood 0 -0.7691265 0 yes serum_phospholipids serum_ARA 0.00674 0.0644 up up no dn no no 18:2n6c+blood TXB2+blood 0 0 0.467123972 yes serum_fattyacid serum_ARA 0.15 0.0644 no no no dn no no 18:3/16:0-PE+blood TXB2+blood 0 -0.501059609 0 yes serum_phospholipids serum_ARA 0.00149 0.0644 up up no dn no no 18:3n3+blood TXB2+blood 0 0 0.575000843 yes serum_fattyacid serum_ARA 0.291 0.0644 no no no dn no no 20:0-LPE+blood TXB2+blood 0 0 0.457877384 yes serum_phospholipids serum_ARA 0.0615 0.0644 no no up dn no no 20:0/20:4-PE+blood TXB2+blood 0 -0.579976497 0 yes serum_phospholipids serum_ARA 0.00128 0.0644 up up no dn no no 20:0/20:5-PC+blood TXB2+blood 0 0.488533119 0 yes serum_phospholipids serum_ARA 0.882 0.0644 no no no dn no no 20:1-LPC+blood TXB2+blood -0.531627109 0 0 yes serum_phospholipids serum_ARA 0.217 0.0644 no no no dn no no 20:1-LPE+blood TXB2+blood -0.625000709 0 0 yes serum_phospholipids serum_ARA 0.465 0.0644 no no no dn no no 20:1/20:4-PC+blood TXB2+blood 0 0.501059609 0 yes serum_phospholipids serum_ARA 0.0419 0.0644 no no up dn no no 20:2-LPC+blood TXB2+blood 0 0 0.479110291 yes serum_phospholipids serum_ARA 0.119 0.0644 no no up dn no no 20:2/18:0-PC+blood TXB2+blood 0 -0.492291066 0 yes serum_phospholipids serum_ARA 0.0427 0.0644 no up no dn no no 20:2/18:1-PE+blood TXB2+blood 0 -0.601271531 0 yes serum_phospholipids serum_ARA 0.00208 0.0644 up up no dn no no 20:3-LPC+blood TXB2+blood 0 -0.587492391 0 yes serum_phospholipids serum_ARA 0.0292 0.0644 no up no dn no no 20:3n6+blood TXB2+blood 0 -0.70398875 0 yes serum_fattyacid serum_ARA 0.0884 0.0644 up no no dn no no 20:4-LPC+blood TXB2+blood 0 0.556176166 0 yes serum_phospholipids serum_ARA 0.949 0.0644 no no no dn no no 20:4/16:0-PE+blood TXB2+blood 0 -0.577471199 0 yes serum_phospholipids serum_ARA 0.00529 0.0644 no up up dn no no 20:4/18:0-PE+blood TXB2+blood 0 0 -0.460274647 yes serum_phospholipids serum_ARA 0.000755 0.0644 up up no dn no no 20:4n6+blood TXB2+blood 0 0.527365238 0 yes serum_fattyacid serum_ARA 0.133 0.0644 no no no dn no no 20:5/18:0-PC+blood TXB2+blood 0 0.577471199 0 yes serum_phospholipids serum_ARA 3.97E-06 0.0644 no up up dn no no 22:6-LPC+blood TXB2+blood 0 0.633840405 0 yes serum_phospholipids serum_ARA 0.127 0.0644 no no up dn no no 22:6n3+blood TXB2+blood 0 0.56369206 0 yes serum_fattyacid serum_ARA 0.792 0.0644 no no no dn no no 8-HETE+blood TXB2+blood 0.596386219 0.488533119 0.449658193 yes serum_ARA serum_ARA 0.741 0.0644 no no no dn no no AA+blood TXB2+blood 0.600904296 0.511080801 0 yes serum_ARA serum_ARA 0.212 0.0644 no no no dn no no Adrenergic signaling in cardiomyocytes TXB2+blood 0 0 -0.405010386 yes kegg serum_ARA NA 0.0644 no no up dn no no Alzheimer disease TXB2+blood -0.5202117 -0.561256548 0 yes kegg serum_ARA NA 0.0644 no no no dn no no Amyotrophic lateral sclerosis TXB2+blood -0.51142434 -0.576183584 0 yes kegg serum_ARA NA 0.0644 no no no dn no no Antigen processing and presentation TXB2+blood 0 0 -0.438921817 yes kegg serum_ARA NA 0.0644 no no no dn no no Bacteroides TXB2+blood 0.445783638 0 0 LPS-producing yes Genus serum_ARA 0.000267 0.0644 dn dn up dn no no Bifidobacterium TXB2+blood 0.452730986 0 0 acetate-producing yes Genus serum_ARA 0.105 0.0644 no dn no dn no no Cardiac muscle contraction TXB2+blood -0.544816307 -0.570212769 0 yes kegg serum_ARA NA 0.0644 no no up dn no no Cellular senescence TXB2+blood 0 0 -0.419653958 yes kegg serum_ARA NA 0.0644 no no no dn no no Choline+blood TXB2+blood 0 0 0.407534844 yes serum_choline serum_ARA 0.0395 0.0644 no up no dn no no Cholinergic synapse TXB2+blood 0 0.528417069 0 yes kegg serum_ARA NA 0.0644 no no no dn no no d18:1-18:0-SM+blood TXB2+blood 0 0.559934113 0 yes serum_phospholipids serum_ARA 0.97 0.0644 no no no dn no no d18:1-20:1-SM+blood TXB2+blood 0 0.632587756 0 yes serum_phospholipids serum_ARA 0.0992 0.0644 no no no dn no no decanoic acid C10+blood TXB2+blood 0 -0.71776789 0 yes serum_mcfa serum_ARA 6.64E-11 0.0644 dn dn no dn no no Diabetic cardiomyopathy TXB2+blood -0.560633555 -0.561256548 0 yes kegg serum_ARA NA 0.0644 no no no dn no no EPA+blood TXB2+blood 0 0.690209611 0 yes serum_ARA serum_ARA 0.212 0.0644 no no no dn no no Epstein-Barr virus infection TXB2+blood 0 0 -0.44662896 yes kegg serum_ARA NA 0.0644 no no no dn no no GCA+stool TXB2+blood 0 0 -0.448288862 yes stool_bileacids serum_ARA 0.0809 0.0644 no no no dn no no GCDCA+blood TXB2+blood 0 -0.528617887 0 yes serum_bileacids serum_ARA 0.31 0.0644 no no no dn no no GCDCA+stool TXB2+blood 0 -0.66529621 0 yes yes stool_bileacids serum_ARA 0.0471 0.0644 no dn no dn no no GDCA+stool TXB2+blood -0.66851849 0 0 yes stool_bileacids serum_ARA 0.656 0.0644 no no no dn no no HCA+blood TXB2+blood 0 -0.483994878 0 yes serum_bileacids serum_ARA 0.544 0.0644 no no no dn no no Herpes simplex virus 1 infection TXB2+blood 0 0 -0.478613605 yes kegg serum_ARA NA 0.0644 no no no dn no no Human cytomegalovirus infection TXB2+blood 0 0 -0.482852534 yes kegg serum_ARA NA 0.0644 no no dn dn no no Human immunodeficiency virus 1 infection TXB2+blood 0 0 -0.442775388 yes kegg serum_ARA NA 0.0644 no no no dn no no Human T-cell leukemia virus 1 infection TXB2+blood 0 0 -0.502120393 yes kegg serum_ARA NA 0.0644 no no no dn no no Huntington disease TXB2+blood -0.536028947 -0.59111062 0 yes kegg serum_ARA NA 0.0644 no no no dn no no Kaposi sarcoma-associated herpesvirus infection TXB2+blood 0 -0.594096027 0 yes kegg serum_ARA NA 0.0644 no no dn dn no no L-Aspartic acid+blood TXB2+blood 0.480422232 0 0 yes yes serum_aminoacids serum_ARA 0.0226 0.0644 up up no dn no no L-Homocystine+blood TXB2+blood -0.695783922 0 0 yes serum_aminoacids serum_ARA 0.197 0.0644 no no no dn no no L-Proline+blood TXB2+blood 0 -0.509828152 0 yes yes serum_aminoacids serum_ARA 0.00265 0.0644 up up no dn no no L-Tyrosine+blood TXB2+blood 0 -0.569955305 0 yes yes serum_aminoacids serum_ARA 0.00913 0.0644 up up no dn no no Long-term potentiation TXB2+blood 0 0 -0.414258958 yes kegg serum_ARA NA 0.0644 no no up dn no no MAPK signaling pathway TXB2+blood 0 0.743366385 0 yes kegg serum_ARA NA 0.0644 no no no dn no no Methanobrevibacter TXB2+blood 0 0 0.469440946 yes Genus serum_ARA 0.629 0.0644 no no no dn no no n3+blood TXB2+blood 0 0.582481795 0 yes serum_fattyacid serum_ARA 0.806 0.0644 no no no dn no no Neurotrophin signaling pathway TXB2+blood -0.50263698 0 0 yes kegg serum_ARA NA 0.0644 no no no dn no no Non-alcoholic fatty liver disease TXB2+blood -0.488577204 -0.61200847 0 yes kegg serum_ARA NA 0.0644 no no no dn no no nutriCA+stool TXB2+blood 0 0 -0.455810487 yes stool_bileacids serum_ARA 0.481 0.0644 no no no dn no no Oxidative phosphorylation TXB2+blood -0.488577204 -0.576183584 0 yes kegg serum_ARA NA 0.0644 no no no dn no no Parabacteroides TXB2+blood 0 0.482269873 0 yes Genus serum_ARA 4.19E-05 0.0644 no up up dn no no Parkinson disease TXB2+blood -0.499122036 -0.513490033 0 yes kegg serum_ARA NA 0.0644 no no no dn no no Pathways of neurodegeneration - multiple diseases TXB2+blood -0.504394452 0 0 yes kegg serum_ARA NA 0.0644 no no no dn no no Phenylacetic acid+stool TXB2+blood 0 0.739734947 0 yes stool_cometabolism serum_ARA 0.785 0.0644 no no no dn no no Prion disease TXB2+blood -0.497364564 -0.540358698 -0.457418961 yes kegg serum_ARA NA 0.0644 no no no dn no no Prostate cancer TXB2+blood -0.469245013 0 0 yes kegg serum_ARA NA 0.0644 no no no dn no no Proteoglycans in cancer TXB2+blood 0 0 -0.518690751 yes kegg serum_ARA NA 0.0644 no no no dn no no PUFA/MUFA+blood TXB2+blood 0 0 0.511644586 yes serum_fattyacid serum_ARA 0.00108 0.0644 dn no up dn no no Retrograde endocannabinoid signaling TXB2+blood -0.495607092 0 0 yes kegg serum_ARA NA 0.0644 no no up dn no no Roseburia TXB2+blood 0.454819793 -0.531448928 0 butyrate-producing yes Genus serum_ARA 0.495 0.0644 no no no dn no no Ruminococcus TXB2+blood 0 -0.518288046 0 yes Genus serum_ARA 0.0679 0.0644 no no dn dn no no Serine+blood TXB2+blood 0 0.53738643 0 yes serum_aminoacids serum_ARA 0.942 0.0644 no no no dn no no Shigellosis TXB2+blood 0 -0.507519219 0 yes kegg serum_ARA NA 0.0644 no no no dn no no TCA+stool TXB2+blood 0 -0.618772 0 yes stool_bileacids serum_ARA 0.458 0.0644 no no no dn no no Th17 cell differentiation TXB2+blood -0.458700181 0 0 yes kegg serum_ARA NA 0.0644 no no no dn no no Thermogenesis TXB2+blood 0 -0.567227362 0 yes kegg serum_ARA NA 0.0644 no no no dn no no TMAO+blood TXB2+blood 0 0.554923517 0 yes serum_choline serum_ARA 0.00706 0.0644 up up no dn no no TUDCA+blood TXB2+blood 0 -0.567286586 0 yes yes serum_bileacids serum_ARA 0.0282 0.0644 no no dn dn no no 2-Oxocarboxylic acid metabolism Type I diabetes mellitus 0.462608696 0 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Type I diabetes mellitus 0 -0.453557312 0 kegg kegg NA NA no no up no no no Aldosterone synthesis and secretion Type I diabetes mellitus 0 -0.618577075 0 kegg kegg NA NA no up up no no no Amino sugar and nucleotide sugar metabolism Type I diabetes mellitus 0 0 -0.414414414 kegg kegg NA NA no no no no no no AMPK signaling pathway Type I diabetes mellitus 0 -0.677865613 0 kegg kegg NA NA no no no no no no Antifolate resistance Type I diabetes mellitus 0 0 -0.457400257 kegg kegg NA NA no no no no no no Antigen processing and presentation Type I diabetes mellitus 0.469565217 0.520750988 0.648906049 kegg kegg NA NA no no no no no no Apelin signaling pathway Type I diabetes mellitus -0.459130435 0 0 kegg kegg NA NA no no no no no no Apoptosis Type I diabetes mellitus 0 0.712450593 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Type I diabetes mellitus 0 0 -0.551866152 kegg kegg NA NA no no no no no no Autophagy - other Type I diabetes mellitus -0.580869565 0 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Type I diabetes mellitus 0 0.483201581 0 kegg kegg NA NA no no no no no no Bacteroides Type I diabetes mellitus 0.433043478 0 0 LPS-producing Genus kegg 0.000267 NA dn dn up no no no Basal transcription factors Type I diabetes mellitus -0.592173913 -0.577075099 -0.534362934 kegg kegg NA NA no no no no no no Base excision repair Type I diabetes mellitus 0 -0.518774704 -0.432175032 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Type I diabetes mellitus 0.570434783 0.583003953 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Type I diabetes mellitus 0 -0.847826087 0 kegg kegg NA NA no no no no no no Butyricicoccus Type I diabetes mellitus 0 0 0.475661054 butyrate-producing Genus kegg 0.852 NA no no no no no no C-type lectin receptor signaling pathway Type I diabetes mellitus 0 0.529644269 0 kegg kegg NA NA no no no no no no cAMP signaling pathway Type I diabetes mellitus -0.452173913 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Type I diabetes mellitus 0.477391304 0.470355731 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Type I diabetes mellitus -0.428695652 0 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Type I diabetes mellitus 0.957391304 0.961462451 0.944401544 kegg kegg NA NA no no no no no no Cell cycle Type I diabetes mellitus -0.607826087 -0.604743083 0 kegg kegg NA NA no no no no no no Cellular senescence Type I diabetes mellitus 0.830434783 0.936758893 0.888803089 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Type I diabetes mellitus 0 0.527667984 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Type I diabetes mellitus 0 0.448616601 0.466924067 kegg kegg NA NA no no no no no no Circadian entrainment Type I diabetes mellitus 0 -0.414031621 0 kegg kegg NA NA no up up no no no Circadian rhythm Type I diabetes mellitus -0.499130435 -0.497035573 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Type I diabetes mellitus 0.528695652 0.56916996 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Type I diabetes mellitus 0 -0.635375494 0 kegg kegg NA NA no no up no no no Cushing syndrome Type I diabetes mellitus 0 -0.700592885 0 kegg kegg NA NA no no up no no no Cytosolic DNA-sensing pathway Type I diabetes mellitus 0 0 0.477220077 kegg kegg NA NA no no no no no no Dopaminergic synapse Type I diabetes mellitus -0.44 -0.536561265 0 kegg kegg NA NA no up no no no no Endocrine resistance Type I diabetes mellitus 0 -0.566205534 0 kegg kegg NA NA no no no no no no Endocytosis Type I diabetes mellitus 0.833043478 0.945652174 0.910939511 kegg kegg NA NA no no no no no no Estrogen signaling pathway Type I diabetes mellitus -0.426956522 -0.492094862 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Type I diabetes mellitus -0.502608696 -0.697628458 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Type I diabetes mellitus 0 -0.550395257 -0.463320463 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Type I diabetes mellitus 0 0.58201581 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Type I diabetes mellitus 0 0.544466403 0 kegg kegg NA NA no no no no no no Folate biosynthesis Type I diabetes mellitus -0.459130435 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Type I diabetes mellitus 0 0 -0.527155727 kegg kegg NA NA no no no no no no Glucagon signaling pathway Type I diabetes mellitus 0 -0.635375494 0 kegg kegg NA NA no no no no no no Glutathione metabolism Type I diabetes mellitus 0 -0.551383399 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Type I diabetes mellitus -0.487826087 -0.459486166 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Type I diabetes mellitus 0 -0.789525692 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Type I diabetes mellitus 0.424347826 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Type I diabetes mellitus 0 0.625494071 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Type I diabetes mellitus 0 -0.755928854 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Type I diabetes mellitus 0 -0.563241107 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Type I diabetes mellitus 0 -0.433794466 0 kegg kegg NA NA no no no no no no Homologous recombination Type I diabetes mellitus 0 -0.492094862 -0.532046332 kegg kegg NA NA no no no no no no IL-17 signaling pathway Type I diabetes mellitus 0 0.561264822 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Type I diabetes mellitus 0 -0.431818182 0 kegg kegg NA NA no no no no no no Insulin resistance Type I diabetes mellitus -0.462608696 0 0 kegg kegg NA NA no no no no no no Insulin secretion Type I diabetes mellitus 0 -0.577075099 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Type I diabetes mellitus -0.450434783 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Type I diabetes mellitus 0.511304348 0.495059289 0.409266409 kegg kegg NA NA no no no no no no Long-term potentiation Type I diabetes mellitus -0.473913043 0 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Type I diabetes mellitus 0 -0.47826087 0 kegg kegg NA NA no no no no no no Lysosome Type I diabetes mellitus 0 0.701581028 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Type I diabetes mellitus -0.595652174 0 0 kegg kegg NA NA no no no no no no Melanogenesis Type I diabetes mellitus 0 -0.41798419 0 kegg kegg NA NA no no no no no no Mismatch repair Type I diabetes mellitus 0 -0.540513834 0 kegg kegg NA NA no no no no no no Mitophagy - animal Type I diabetes mellitus 0 -0.507905138 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Type I diabetes mellitus -0.593043478 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Type I diabetes mellitus 0.822608696 0.951581028 0.902960103 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Type I diabetes mellitus 0 0.608695652 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Type I diabetes mellitus 0 0.499011858 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Type I diabetes mellitus 0.406086957 0.605731225 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Type I diabetes mellitus 0 0.496047431 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Type I diabetes mellitus -0.504347826 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Type I diabetes mellitus 0 -0.585968379 -0.534362934 kegg kegg NA NA no no no no no no One carbon pool by folate Type I diabetes mellitus 0 -0.540513834 0 kegg kegg NA NA no no no no no no Oocyte meiosis Type I diabetes mellitus -0.542608696 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Type I diabetes mellitus 0 0.593873518 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Type I diabetes mellitus -0.529565217 -0.522727273 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Type I diabetes mellitus 0 -0.473320158 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Type I diabetes mellitus -0.460869565 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Type I diabetes mellitus -0.511304348 -0.476284585 -0.542084942 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Type I diabetes mellitus -0.406086957 -0.447628458 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Type I diabetes mellitus 0.453043478 0.659090909 0 kegg kegg NA NA no no no no no no Phagosome Type I diabetes mellitus 0.895652174 0.913043478 0.814929215 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Type I diabetes mellitus -0.53826087 0 0 yes kegg kegg NA NA no up up no no no Platinum drug resistance Type I diabetes mellitus 0 0 -0.575289575 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Type I diabetes mellitus 0 -0.751976285 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Type I diabetes mellitus 0 0.456521739 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Type I diabetes mellitus -0.429565217 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Type I diabetes mellitus 0 0.464426877 0 kegg kegg NA NA no no no no no no Protein export Type I diabetes mellitus -0.557391304 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Type I diabetes mellitus 0 -0.472332016 0 kegg kegg NA NA no no no no no no Purine metabolism Type I diabetes mellitus 0 -0.754940711 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Type I diabetes mellitus 0 -0.422924901 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Type I diabetes mellitus 0 -0.43083004 0 kegg kegg NA NA no no no no no no Renin secretion Type I diabetes mellitus 0 -0.419960474 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Type I diabetes mellitus 0 0.675889328 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Type I diabetes mellitus -0.517391304 0 0 kegg kegg NA NA no no up no no no Ribosome biogenesis in eukaryotes Type I diabetes mellitus -0.432173913 -0.526679842 0 kegg kegg NA NA no no no no no no RNA degradation Type I diabetes mellitus -0.503478261 0 0 kegg kegg NA NA no no no no no no RNA polymerase Type I diabetes mellitus -0.46173913 -0.563241107 0 kegg kegg NA NA no no no no no no Ruminococcus Type I diabetes mellitus 0 0 0.400772201 acetate-producing Genus kegg 0.335 NA no no no no no no Selenocompound metabolism Type I diabetes mellitus -0.53826087 -0.518774704 -0.467696268 kegg kegg NA NA no no no no no no Sphingolipid metabolism Type I diabetes mellitus 0 0.453557312 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Type I diabetes mellitus 0 0.71541502 0 kegg kegg NA NA no no no no no no Spliceosome Type I diabetes mellitus -0.415652174 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Type I diabetes mellitus -0.605217391 0 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Type I diabetes mellitus 0 0.459486166 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Type I diabetes mellitus 0 -0.585968379 -0.424453024 kegg kegg NA NA no no no no no no Taste transduction Type I diabetes mellitus -0.659130435 -0.58201581 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Type I diabetes mellitus -0.414782609 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Type I diabetes mellitus -0.695652174 0 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Type I diabetes mellitus 0 0.585968379 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Type I diabetes mellitus 0 0.557312253 0 kegg kegg NA NA no no no no no no Thermogenesis Type I diabetes mellitus -0.436521739 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Type I diabetes mellitus 0 -0.598814229 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Type I diabetes mellitus 0 -0.509881423 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Type I diabetes mellitus 0 0.490118577 0.459202059 yes kegg kegg NA NA no no no no no no Tyrosine metabolism Type I diabetes mellitus 0 -0.450592885 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Type I diabetes mellitus 0 -0.442687747 -0.421621622 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Type I diabetes mellitus 0 -0.56916996 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Type II diabetes mellitus -0.531304348 -0.486166008 0 kegg kegg NA NA no no no no no no ABC transporters Type II diabetes mellitus 0 0.544466403 0.40978121 kegg kegg NA NA no up up no no no Adherens junction Type II diabetes mellitus -0.453913043 -0.683794466 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Type II diabetes mellitus 0 0.461462451 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Type II diabetes mellitus 0 0.567193676 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Type II diabetes mellitus 0 -0.490118577 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Type II diabetes mellitus 0 -0.615612648 0 kegg kegg NA NA no no no no no no Apoptosis Type II diabetes mellitus 0 0.47826087 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Type II diabetes mellitus 0 0.499011858 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Type II diabetes mellitus -0.586086957 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Type II diabetes mellitus 0 0.59486166 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Type II diabetes mellitus 0 0.500988142 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Type II diabetes mellitus 0 -0.418972332 0.416473616 kegg kegg NA NA no no no no no no Autophagy - animal Type II diabetes mellitus 0.807826087 0.830039526 0.697039897 kegg kegg NA NA no no no no no no Autophagy - other Type II diabetes mellitus 0.594782609 0.580039526 0.423680824 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Type II diabetes mellitus 0.416521739 0.656126482 0.444787645 kegg kegg NA NA no no no no no no beta-Alanine metabolism Type II diabetes mellitus -0.570434783 -0.556324111 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Type II diabetes mellitus -0.619130435 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Type II diabetes mellitus -0.610434783 -0.470355731 0 kegg kegg NA NA no no no no no no Butanoate metabolism Type II diabetes mellitus -0.607826087 -0.609683794 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Type II diabetes mellitus 0.806086957 0.674901186 0.533590734 kegg kegg NA NA no no no no no no cAMP signaling pathway Type II diabetes mellitus 0.539130435 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Type II diabetes mellitus -0.466086957 -0.432806324 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Type II diabetes mellitus 0 -0.557312253 0 kegg kegg NA NA no no up no no no cGMP-PKG signaling pathway Type II diabetes mellitus 0.496521739 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Type II diabetes mellitus 0.714782609 0.461462451 0.54980695 kegg kegg NA NA no no no no no no Circadian entrainment Type II diabetes mellitus 0 -0.545454545 -0.538738739 kegg kegg NA NA no up up no no no Circadian rhythm Type II diabetes mellitus 0.523478261 0 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Type II diabetes mellitus -0.56173913 -0.710474308 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Type II diabetes mellitus 0 -0.623517787 0 kegg kegg NA NA no no no no no no DNA replication Type II diabetes mellitus 0 -0.519762846 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Type II diabetes mellitus 0 -0.467391304 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Type II diabetes mellitus -0.407826087 -0.726284585 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Type II diabetes mellitus -0.539130435 -0.778656126 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Type II diabetes mellitus 0 -0.438735178 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Type II diabetes mellitus 0.759130435 0.881422925 0.612097812 kegg kegg NA NA no no no no no no Estrogen signaling pathway Type II diabetes mellitus 0 -0.497035573 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Type II diabetes mellitus 0 0.603754941 0.445559846 kegg kegg NA NA no no no no no no Fatty acid degradation Type II diabetes mellitus 0 0.420948617 0 kegg kegg NA NA no no no no no no Fatty acid elongation Type II diabetes mellitus -0.655652174 -0.570158103 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Type II diabetes mellitus 0.574782609 0.671936759 0.629343629 kegg kegg NA NA no no no no no no Focal adhesion Type II diabetes mellitus -0.455652174 -0.736166008 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Type II diabetes mellitus 0.510434783 0.753952569 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Type II diabetes mellitus 0 0.540513834 0.460746461 kegg kegg NA NA no no no no no no GABAergic synapse Type II diabetes mellitus 0 0.509881423 0 kegg kegg NA NA no up up no no no Galactose metabolism Type II diabetes mellitus 0 0.532608696 0.526640927 kegg kegg NA NA no no no no no no Gap junction Type II diabetes mellitus 0 0 -0.483912484 kegg kegg NA NA no no no no no no Glutamatergic synapse Type II diabetes mellitus 0 0.419960474 0 kegg kegg NA NA no up up no no no Glutathione metabolism Type II diabetes mellitus -0.490434783 -0.528656126 -0.469240669 kegg kegg NA NA no no no no no no Glycerolipid metabolism Type II diabetes mellitus 0 0.638339921 0.512998713 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Type II diabetes mellitus 0 0.565217391 0.517117117 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Type II diabetes mellitus -0.506956522 0 0 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Type II diabetes mellitus -0.517391304 -0.756916996 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Type II diabetes mellitus 0.512173913 0.842885375 0.492149292 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Type II diabetes mellitus -0.470434783 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Type II diabetes mellitus 0 0 0.467438867 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Type II diabetes mellitus 0 0.416007905 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Type II diabetes mellitus 0 0.493083004 0 kegg kegg NA NA no no no no no no GnRH secretion Type II diabetes mellitus 0.802608696 0.87944664 0.717374517 kegg kegg NA NA no up up no no no Hedgehog signaling pathway Type II diabetes mellitus 0 0 0.44967825 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Type II diabetes mellitus 0 -0.575098814 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Type II diabetes mellitus -0.520869565 -0.661067194 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Type II diabetes mellitus 0 0.549407115 0.564993565 kegg kegg NA NA no no no no no no IL-17 signaling pathway Type II diabetes mellitus 0.451304348 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Type II diabetes mellitus 0 -0.43972332 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Type II diabetes mellitus 0 0.553359684 0.512483912 kegg kegg NA NA no no no no no no Insulin signaling pathway Type II diabetes mellitus 0 -0.53458498 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Type II diabetes mellitus 0.452173913 0.799407115 0.501673102 kegg kegg NA NA no no no no no no Long-term potentiation Type II diabetes mellitus 0 -0.446640316 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Type II diabetes mellitus 0.410434783 0 0 kegg kegg NA NA no no no no no no Lysine degradation Type II diabetes mellitus 0 0 0.426512227 kegg kegg NA NA no no no no no no MAPK signaling pathway Type II diabetes mellitus 0 0.466403162 0.542084942 kegg kegg NA NA no no no no no no Melanogenesis Type II diabetes mellitus 0 -0.436758893 -0.404118404 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Type II diabetes mellitus -0.46 -0.764822134 0 kegg kegg NA NA no no no no no no Mismatch repair Type II diabetes mellitus -0.551304348 -0.480237154 0 kegg kegg NA NA no no no no no no Mitophagy - animal Type II diabetes mellitus 0 0 -0.491634492 kegg kegg NA NA no no no no no no mTOR signaling pathway Type II diabetes mellitus 0 -0.434782609 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Type II diabetes mellitus 0 -0.428853755 0 kegg kegg NA NA no no no no no no Necroptosis Type II diabetes mellitus 0 0 -0.437837838 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Type II diabetes mellitus 0.680869565 0.593873518 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Type II diabetes mellitus 0.473913043 0.793478261 0.507078507 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Type II diabetes mellitus 0 0.580039526 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Type II diabetes mellitus 0 0.493083004 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Type II diabetes mellitus 0 0.612648221 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Type II diabetes mellitus -0.602608696 -0.565217391 0 kegg kegg NA NA no no no no no no Notch signaling pathway Type II diabetes mellitus 0.456521739 0.681818182 0.572715573 kegg kegg NA NA no no no no no no Nucleotide excision repair Type II diabetes mellitus 0 -0.423913043 0 kegg kegg NA NA no no no no no no Oocyte meiosis Type II diabetes mellitus 0 -0.593873518 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Type II diabetes mellitus 0 0.532608696 0 kegg kegg NA NA no no no no no no Other glycan degradation Type II diabetes mellitus 0 0.468379447 0.556241956 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Type II diabetes mellitus 0 0 0.434234234 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Type II diabetes mellitus 0 0 -0.427541828 kegg kegg NA NA no up up no no no Oxidative phosphorylation Type II diabetes mellitus 0 -0.608695652 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Type II diabetes mellitus -0.440869565 -0.579051383 -0.443500644 kegg kegg NA NA no no no no no no p53 signaling pathway Type II diabetes mellitus 0.42173913 0.440711462 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Type II diabetes mellitus 0 0.435770751 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Type II diabetes mellitus -0.667826087 -0.621541502 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Type II diabetes mellitus -0.65826087 -0.64229249 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Type II diabetes mellitus 0 0 0.453024453 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Type II diabetes mellitus 0 0.674901186 0 kegg kegg NA NA no up up no no no Phototransduction Type II diabetes mellitus 0 -0.792490119 0 kegg kegg NA NA no no no no no no Platelet activation Type II diabetes mellitus -0.466956522 -0.630434783 0 kegg kegg NA NA no no no no no no Platinum drug resistance Type II diabetes mellitus 0 0.537549407 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Type II diabetes mellitus -0.448695652 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Type II diabetes mellitus 0 0.434782609 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Type II diabetes mellitus -0.571304348 -0.589920949 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Type II diabetes mellitus 0.586956522 0.484189723 0.482625483 kegg kegg NA NA no no no no no no Prolactin signaling pathway Type II diabetes mellitus 0.774782609 0.727272727 0.762162162 kegg kegg NA NA no no no no no no Propanoate metabolism Type II diabetes mellitus 0 -0.626482213 0 kegg kegg NA NA no no no no no no Proteasome Type II diabetes mellitus 0 -0.763833992 0 kegg kegg NA NA no no no no no no Protein export Type II diabetes mellitus 0 -0.646245059 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Type II diabetes mellitus 0 -0.47826087 -0.473616474 kegg kegg NA NA no no no no no no Pyrimidine metabolism Type II diabetes mellitus -0.427826087 -0.449604743 0.482110682 kegg kegg NA NA no no no no no no Pyruvate metabolism Type II diabetes mellitus -0.412173913 -0.668972332 -0.412612613 kegg kegg NA NA no no no no no no Rap1 signaling pathway Type II diabetes mellitus 0 -0.455533597 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Type II diabetes mellitus -0.546086957 -0.666007905 -0.468468468 kegg kegg NA NA no no no no no no Relaxin signaling pathway Type II diabetes mellitus 0.569565217 0.504940711 0 kegg kegg NA NA no no no no no no Renin secretion Type II diabetes mellitus 0 -0.618577075 -0.538223938 kegg kegg NA NA no no no no no no Retinol metabolism Type II diabetes mellitus -0.433043478 0 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Type II diabetes mellitus 0 -0.684782609 0 kegg kegg NA NA no no up no no no Ribosome Type II diabetes mellitus 0 -0.593873518 -0.502960103 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Type II diabetes mellitus 0.672173913 0.752964427 0 kegg kegg NA NA no no no no no no RNA transport Type II diabetes mellitus 0 -0.418972332 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Type II diabetes mellitus 0 0 0.435778636 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Type II diabetes mellitus 0.694782609 0.687747036 0.492921493 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Type II diabetes mellitus 0 0.561264822 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Type II diabetes mellitus 0 0 0.457657658 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Type II diabetes mellitus 0.725217391 0 0.473616474 kegg kegg NA NA no no no no no no Spliceosome Type II diabetes mellitus 0 0.444664032 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Type II diabetes mellitus 0 0.52173913 0.502702703 kegg kegg NA NA no no no no no no Steroid biosynthesis Type II diabetes mellitus 0 -0.52173913 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Type II diabetes mellitus -0.588695652 -0.436758893 0 kegg kegg NA NA no no no no no no Sulfur metabolism Type II diabetes mellitus -0.58 -0.456521739 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Type II diabetes mellitus 0.509565217 0.554347826 0 kegg kegg NA NA no no no no no no Taste transduction Type II diabetes mellitus 0 0 0.410553411 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Type II diabetes mellitus 0.429565217 0.776679842 0.446846847 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Type II diabetes mellitus 0 -0.529644269 0 kegg kegg NA NA no no no no no no Thermogenesis Type II diabetes mellitus 0 -0.632411067 -0.545945946 kegg kegg NA NA no no no no no no Thiamine metabolism Type II diabetes mellitus 0 -0.496047431 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Type II diabetes mellitus 0 -0.468379447 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Type II diabetes mellitus 0 0 -0.518146718 kegg kegg NA NA no no no no no no Tight junction Type II diabetes mellitus -0.597391304 -0.774703557 -0.441184041 kegg kegg NA NA no no no no no no TNF signaling pathway Type II diabetes mellitus 0.8 0.756916996 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Type II diabetes mellitus 0.760869565 0.62055336 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Type II diabetes mellitus -0.583478261 -0.609683794 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Type II diabetes mellitus -0.669565217 -0.585968379 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Type II diabetes mellitus -0.557391304 -0.447628458 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Type II diabetes mellitus 0 -0.434782609 -0.506563707 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Type II diabetes mellitus -0.531304348 -0.564229249 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Type II diabetes mellitus 0 -0.670948617 -0.524581725 kegg kegg NA NA no no no no no no VEGF signaling pathway Type II diabetes mellitus 0.732173913 0.721343874 0.52046332 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Type II diabetes mellitus 0 0 -0.483655084 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Tyrosine metabolism 0 -0.522727273 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Tyrosine metabolism 0 -0.561264822 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Tyrosine metabolism 0 -0.537549407 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Tyrosine metabolism 0.513043478 0.47826087 0.418018018 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Tyrosine metabolism 0.76 0.820158103 0.58043758 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Tyrosine metabolism 0.633913043 0.804347826 0.555212355 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Tyrosine metabolism 0 -0.480237154 0 kegg kegg NA NA no no no no no no Fatty acid degradation Tyrosine metabolism 0 0 0.421106821 kegg kegg NA NA no no no no no no Fatty acid elongation Tyrosine metabolism 0.674782609 0.621541502 0.69009009 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Tyrosine metabolism 0.440869565 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Tyrosine metabolism 0.448695652 0 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Tyrosine metabolism 0.760869565 0.659090909 0.601544402 kegg kegg NA NA no no no no no no Histidine metabolism Tyrosine metabolism 0.573913043 0 0.578893179 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Tyrosine metabolism 0.782608696 0.75 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Tyrosine metabolism 0.788695652 0.66798419 0.614929215 kegg kegg NA NA no no no no no no Pyrimidine metabolism Tyrosine metabolism 0.644347826 0.789525692 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Tyrosine metabolism 0 0.802371542 0.56988417 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Tyrosine metabolism 0.689565217 0.901185771 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Tyrosine metabolism 0.643478261 0.791501976 0.575804376 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Tyrosine metabolism 0.743478261 0.839920949 0.621106821 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Tyrosine metabolism 0.776521739 0.862648221 0.738223938 kegg kegg NA NA no no no no no no 13-HODE+blood UA+clinic 0 0.642857143 0 serum_ARA clinic 0.32 0.855 no no no no no no 16:0-LPC+blood UA+clinic 0.479876161 0 0 serum_phospholipids clinic 0.00456 0.855 up up no no no no 16:0/18:2-PC+blood UA+clinic 0 0.6 0 serum_phospholipids clinic 3.24E-06 0.855 no up up no no no 16:1/16:0-PC+blood UA+clinic 0 0.542857143 0 serum_phospholipids clinic 0.0215 0.855 no up up no no no 16:1+blood UA+clinic 0 0 0.469230769 yes serum_fattyacid clinic 0.0186 0.855 no no dn no no no 18:0/16:0-PC+blood UA+clinic 0 0.535714286 0 serum_phospholipids clinic 9.64E-07 0.855 up up up no no no 18:1-LPE+blood UA+clinic 0 0 -0.451538462 serum_phospholipids clinic 0.117 0.855 no no no no no no 18:1/16:0-PC+blood UA+clinic 0 0.614285714 0 serum_phospholipids clinic 2.43E-05 0.855 no up up no no no 18:1/18:2-PI+blood UA+clinic 0 0 -0.426923077 serum_phospholipids clinic 0.0164 0.855 dn no up no no no 18:3n6+blood UA+clinic 0 -0.764285714 0 serum_fattyacid clinic 0.0463 0.855 up no dn no no no 20:1-LPA+blood UA+clinic 0 0 -0.449230769 serum_phospholipids clinic 0.0187 0.855 dn dn no no no no 4-hydroxybenzoic acid+stool UA+clinic 0 0 -0.459062676 stool_cometabolism clinic 0.0536 0.855 no dn no no no no 4-hydroxybenzoic acid+urine UA+clinic 0 0.754901961 0 urine_cometabolism clinic 0.52 0.855 no no no no no no ACA+blood UA+clinic 0 -0.516670556 0 serum_bileacids clinic 0.338 0.855 no no no no no no AGE-RAGE signaling pathway in diabetic complications UA+clinic 0.43083004 0 0 kegg clinic NA 0.855 no no no no no no Alcoholism UA+clinic -0.509881423 0 0 kegg clinic NA 0.855 no no no no no no Axon guidance UA+clinic -0.442123094 0 0 kegg clinic NA 0.855 no up up no no no Chemokine signaling pathway UA+clinic -0.4432524 0 0 kegg clinic NA 0.855 no no no no no no Collinsella UA+clinic 0.418581678 0 0 Genus clinic 0.128 0.855 no no no no no no Colorectal cancer UA+clinic 0 -0.545454545 0 kegg clinic NA 0.855 no no no no no no Creatinine+blood UA+clinic 0.529411765 0 0 serum_choline clinic 0.437 0.855 no no no no no no Cystine+blood UA+clinic 0 0.542857143 0 yes serum_aminoacids clinic 0.00028 0.855 up up no no no no Cytosolic DNA-sensing pathway UA+clinic -0.61038961 0 0 kegg clinic NA 0.855 no no no no no no d18:1-20:0-SM+blood UA+clinic 0 0 -0.409230769 serum_phospholipids clinic 0.933 0.855 no no no no no no d18:1-22:0-SM+blood UA+clinic -0.512899897 0 0 serum_phospholipids clinic 0.522 0.855 no no no no no no d18:1-22:1-SM+blood UA+clinic -0.488132095 0 0 serum_phospholipids clinic 0.222 0.855 no no no no no no Dorea UA+clinic 0 0 -0.506901003 Genus clinic 0.00362 0.855 up no dn no no no Endocrine resistance UA+clinic 0 -0.449350649 0 kegg clinic NA 0.855 no no no no no no Epstein-Barr virus infection UA+clinic -0.460191982 0 0 kegg clinic NA 0.855 no no no no no no FGF basic UA+clinic -0.582417582 0 0 serum_cytokines clinic 0.65 0.855 no no no no no no Glycine+blood UA+clinic 0 0.621428571 0 serum_aminoacids clinic 0.00408 0.855 dn no up no no no Hematopoietic cell lineage UA+clinic 0.509881423 0 0 kegg clinic NA 0.855 no no no no no no Herpes simplex virus 1 infection UA+clinic -0.472614342 0 0 kegg clinic NA 0.855 no no no no no no Human cytomegalovirus infection UA+clinic -0.541501976 0 0 kegg clinic NA 0.855 no no dn no no no Human immunodeficiency virus 1 infection UA+clinic -0.485036702 0 0 kegg clinic NA 0.855 no no no no no no Human T-cell leukemia virus 1 infection UA+clinic -0.46809712 0 0 kegg clinic NA 0.855 no no no no no no IP-10 UA+clinic 0.763736264 0 0 serum_cytokines clinic 0.394 0.855 no no no no no no L-Glutamine+blood UA+clinic 0 0.571428571 0 serum_aminoacids clinic 0.639 0.855 no no no no no no L-Isoleucine+blood UA+clinic 0.581011352 0 0 yes serum_aminoacids clinic 5.47E-06 0.855 up up no no no no L-Leucine+blood UA+clinic 0.512899897 0 0 yes serum_aminoacids clinic 3.22E-05 0.855 up up no no no no L-Lysine+blood UA+clinic 0 0.528571429 0 yes serum_aminoacids clinic 0.0107 0.855 no up no no no no L-Phenylalanine+urine UA+clinic 0 -0.602941176 0 urine_cometabolism clinic 0.0908 0.855 no up no no no no L-Threonine+blood UA+clinic 0 0.542857143 0 serum_aminoacids clinic 0.0538 0.855 dn no up no no no L-Tryptophan+blood UA+clinic 0.512899897 0 0 serum_aminoacids clinic 0.164 0.855 no no no no no no L-Tryptophan+urine UA+clinic 0 -0.495098039 0 urine_cometabolism clinic 0.226 0.855 no no no no no no L-Tyrosine+urine UA+clinic 0 -0.56372549 0 urine_cometabolism clinic 0.45 0.855 no no no no no no Longevity regulating pathway - multiple species UA+clinic 0 0 0.448739496 kegg clinic NA 0.855 no no no no no no MUFA%+blood UA+clinic 0 0.685714286 0 serum_fattyacid clinic 0.00142 0.855 up no dn no no no Neurotrophin signaling pathway UA+clinic -0.436476567 0 0 kegg clinic NA 0.855 no no no no no no Phosphatidylinositol signaling system UA+clinic 0 -0.561038961 0 kegg clinic NA 0.855 no no no no no no Prevotella UA+clinic 0 -0.4894446 0 acetate-producing Genus clinic 0.287 0.855 no no no no no no Proteasome UA+clinic 0 0 0.423809524 kegg clinic NA 0.855 no no no no no no PUFA%+blood UA+clinic 0 0.610714286 0 serum_fattyacid clinic 0.0013 0.855 dn no up no no no RANTES UA+clinic 0.802197802 0 0 yes serum_cytokines clinic 0.0757 0.855 no no up no no no Serine+blood UA+clinic 0 0.6 0 serum_aminoacids clinic 0.942 0.855 no no no no no no SFA%+blood UA+clinic 0 0.628571429 0 serum_fattyacid clinic 0.0236 0.855 no up no no no no Taurine+blood UA+clinic 0 0.6 0 serum_aminoacids clinic 0.857 0.855 no no no no no no TDCA+blood UA+clinic 0 -0.601719207 0 yes serum_bileacids clinic 0.155 0.855 no up no no no no UDCA+blood UA+clinic 0 0 0.441619317 yes serum_bileacids clinic 0.0939 0.855 no no dn no no no UFA%+blood UA+clinic 0 0.696428571 0 serum_fattyacid clinic 0.0236 0.855 no dn no no no no Valine+blood UA+clinic 0.535603715 0 0 yes serum_aminoacids clinic 1.22E-06 0.855 up up no no no no Ascorbate and aldarate metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.686956522 0.580039526 0.631402831 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Ubiquinone and other terpenoid-quinone biosynthesis 0.773913043 0.840909091 0.712226512 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.429841897 0 kegg kegg NA NA no no no no no no Fatty acid degradation Ubiquinone and other terpenoid-quinone biosynthesis 0.408695652 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Ubiquinone and other terpenoid-quinone biosynthesis 0.66173913 0.559288538 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.572173913 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.635652174 0 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis Ubiquinone and other terpenoid-quinone biosynthesis 0.595652174 0.460474308 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Ubiquinone and other terpenoid-quinone biosynthesis 0.730434783 0.788537549 0.488288288 kegg kegg NA NA no no no no no no Pentose phosphate pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.448616601 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis 0.890434783 0.605731225 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis 0 0.748023715 0.590990991 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Ubiquinone and other terpenoid-quinone biosynthesis 0.780869565 0.856719368 0.724066924 kegg kegg NA NA no no no no no no ABC transporters Ubiquitin mediated proteolysis -0.41826087 0 0 kegg kegg NA NA no up up no no no "Alanine, aspartate and glutamate metabolism" Ubiquitin mediated proteolysis -0.55826087 -0.488142292 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Ubiquitin mediated proteolysis -0.476521739 -0.599802372 -0.466666667 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Ubiquitin mediated proteolysis -0.455652174 0 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Ubiquitin mediated proteolysis -0.522608696 -0.62055336 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Ubiquitin mediated proteolysis -0.603478261 -0.457509881 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Ubiquitin mediated proteolysis -0.49826087 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Ubiquitin mediated proteolysis -0.60173913 -0.657114625 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Ubiquitin mediated proteolysis 0 0.58201581 0.551351351 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Ubiquitin mediated proteolysis -0.515652174 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Ubiquitin mediated proteolysis 0.556521739 0.645256917 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Ubiquitin mediated proteolysis 0.531304348 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Ubiquitin mediated proteolysis -0.470434783 0 0 kegg kegg NA NA no no no no no no Cell cycle Ubiquitin mediated proteolysis 0 0.447628458 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Ubiquitin mediated proteolysis 0 -0.691699605 -0.465637066 kegg kegg NA NA no no no no no no Chemokine signaling pathway Ubiquitin mediated proteolysis 0 -0.467391304 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Ubiquitin mediated proteolysis 0 -0.500988142 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Ubiquitin mediated proteolysis 0.52173913 0.580039526 0 kegg kegg NA NA no no no no no no Endocrine resistance Ubiquitin mediated proteolysis 0.519130435 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Ubiquitin mediated proteolysis 0 0 -0.569111969 kegg kegg NA NA no no no no no no Ether lipid metabolism Ubiquitin mediated proteolysis 0.659130435 0.496047431 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Ubiquitin mediated proteolysis -0.676521739 -0.62055336 0 kegg kegg NA NA no no no no no no Fatty acid degradation Ubiquitin mediated proteolysis -0.824347826 -0.646245059 0 kegg kegg NA NA no no no no no no Fatty acid elongation Ubiquitin mediated proteolysis -0.49826087 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Ubiquitin mediated proteolysis -0.846956522 -0.698616601 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Ubiquitin mediated proteolysis -0.51826087 -0.57312253 0 kegg kegg NA NA no no no no no no Galactose metabolism Ubiquitin mediated proteolysis -0.586086957 -0.711462451 0 kegg kegg NA NA no no no no no no Glutathione metabolism Ubiquitin mediated proteolysis 0.439130435 0.707509881 0.597683398 kegg kegg NA NA no no no no no no Glycerolipid metabolism Ubiquitin mediated proteolysis 0 -0.431818182 -0.434234234 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Ubiquitin mediated proteolysis 0.413043478 0.652173913 0.545688546 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Ubiquitin mediated proteolysis -0.446956522 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Ubiquitin mediated proteolysis 0 -0.540513834 -0.458429858 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Ubiquitin mediated proteolysis 0 0 -0.415958816 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Ubiquitin mediated proteolysis 0.559130435 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Ubiquitin mediated proteolysis 0 -0.571146245 -0.587644788 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Ubiquitin mediated proteolysis -0.640869565 -0.483201581 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Ubiquitin mediated proteolysis 0 0.496047431 0 kegg kegg NA NA no no no no no no Histidine metabolism Ubiquitin mediated proteolysis -0.452173913 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Ubiquitin mediated proteolysis 0 0 -0.425997426 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Ubiquitin mediated proteolysis 0.509565217 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Ubiquitin mediated proteolysis -0.425217391 -0.468379447 -0.474903475 kegg kegg NA NA no no no no no no mRNA surveillance pathway Ubiquitin mediated proteolysis 0.587826087 0.613636364 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Ubiquitin mediated proteolysis 0 0.425889328 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Ubiquitin mediated proteolysis -0.540869565 -0.705533597 0 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Ubiquitin mediated proteolysis -0.46173913 -0.462450593 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Ubiquitin mediated proteolysis -0.655652174 -0.635375494 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Ubiquitin mediated proteolysis -0.410434783 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Ubiquitin mediated proteolysis -0.492173913 0 0 kegg kegg NA NA no no no no no no Other glycan degradation Ubiquitin mediated proteolysis 0 0 -0.583011583 kegg kegg NA NA no no no no no no Oxidative phosphorylation Ubiquitin mediated proteolysis 0.487826087 0.808300395 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Ubiquitin mediated proteolysis -0.748695652 -0.709486166 0 kegg kegg NA NA no no dn no no no Pentose phosphate pathway Ubiquitin mediated proteolysis 0 -0.716403162 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Ubiquitin mediated proteolysis 0.42 0.701581028 0.636036036 kegg kegg NA NA no no no no no no PPAR signaling pathway Ubiquitin mediated proteolysis 0 -0.514822134 0 kegg kegg NA NA no no no no no no Protein export Ubiquitin mediated proteolysis 0.463478261 0.56027668 0 kegg kegg NA NA no no no no no no Purine metabolism Ubiquitin mediated proteolysis 0.469565217 0.696640316 0.804118404 kegg kegg NA NA no no no no no no Pyrimidine metabolism Ubiquitin mediated proteolysis -0.486086957 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Ubiquitin mediated proteolysis 0 0.46541502 0.435006435 kegg kegg NA NA no no no no no no Retinol metabolism Ubiquitin mediated proteolysis -0.550434783 0 0 kegg kegg NA NA no no no no no no Ribosome Ubiquitin mediated proteolysis 0.794782609 0.750988142 0.563191763 kegg kegg NA NA no no no no no no RNA degradation Ubiquitin mediated proteolysis 0.579130435 0.530632411 0 kegg kegg NA NA no no no no no no RNA polymerase Ubiquitin mediated proteolysis 0 0.588932806 0 kegg kegg NA NA no no no no no no RNA transport Ubiquitin mediated proteolysis 0 0.467391304 0 kegg kegg NA NA no no no no no no Ruminococcus Ubiquitin mediated proteolysis 0.450434783 0 0 acetate-producing Genus kegg 0.335 NA no no no no no no Sphingolipid metabolism Ubiquitin mediated proteolysis 0 0 -0.541312741 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Ubiquitin mediated proteolysis 0 -0.491106719 -0.684684685 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Ubiquitin mediated proteolysis -0.622608696 -0.691699605 0 kegg kegg NA NA no no no no no no Sulfur metabolism Ubiquitin mediated proteolysis 0 0 0.50965251 kegg kegg NA NA no no no no no no Thiamine metabolism Ubiquitin mediated proteolysis 0 0.429841897 0 kegg kegg NA NA no no no no no no 12-ketoDCA+blood UDCA+blood 0.46479835 0 0 yes serum_bileacids serum_bileacids 0.517 0.0939 no no no no no dn 14:0-LPC+blood UDCA+blood 0.4776232 0 0 yes serum_phospholipids serum_bileacids 0.00689 0.0939 up up no no no dn 16:0/16:1-PI+blood UDCA+blood 0.509214026 0 0 yes serum_phospholipids serum_bileacids 0.262 0.0939 no no no no no dn 16:0/18:0-PC+blood UDCA+blood -0.567882703 0 -0.530822696 yes serum_phospholipids serum_bileacids 0.521 0.0939 no no no no no dn 16:0/18:0-PS+blood UDCA+blood -0.488153476 0 0 yes serum_phospholipids serum_bileacids 0.377 0.0939 no no no no no dn 16:0/18:1-PC+blood UDCA+blood -0.525009439 0 0 yes serum_phospholipids serum_bileacids 6.15E-07 0.0939 up up up no no dn 16:0/20:3-PC+blood UDCA+blood 0 0.489270478 0 yes serum_phospholipids serum_bileacids 5.43E-06 0.0939 no up up no no dn 16:0/20:5-PG+blood UDCA+blood -0.4716059 0 0 yes serum_phospholipids serum_bileacids 0.00656 0.0939 no up no no no dn 16:0/22:6-PC+blood UDCA+blood -0.497179426 0 0 yes serum_phospholipids serum_bileacids 4.53E-05 0.0939 no up up no no dn 16:1-LPC+blood UDCA+blood 0 -0.534641425 0 yes serum_phospholipids serum_bileacids 0.0241 0.0939 no up no no no dn 16:1/16:0-PC+blood UDCA+blood -0.522752952 0 0 yes serum_phospholipids serum_bileacids 0.0215 0.0939 no up up no no dn 16:1/16:1-PC+blood UDCA+blood -0.663407343 0 0 yes serum_phospholipids serum_bileacids 0.0177 0.0939 no no up no no dn 16:1/18:1-PG+blood UDCA+blood -0.528770252 0 0 yes serum_phospholipids serum_bileacids 3.21E-05 0.0939 no up up no no dn 16:1/18:2-PG+blood UDCA+blood -0.513727001 0 0 yes serum_phospholipids serum_bileacids 1.40E-08 0.0939 no up up no no dn 18:0/16:0-PC+blood UDCA+blood -0.558856753 0 0 yes serum_phospholipids serum_bileacids 9.64E-07 0.0939 up up up no no dn 18:0/18:0-PC+blood UDCA+blood 0 0.526057732 -0.573288512 yes serum_phospholipids serum_bileacids 0.426 0.0939 no no no no no dn 18:0/18:0-PS+blood UDCA+blood -0.602482179 0 0 yes serum_phospholipids serum_bileacids 0.00617 0.0939 no up no no no dn 18:0/18:1-PC+blood UDCA+blood 0 0.575107404 -0.59452142 yes serum_phospholipids serum_bileacids 0.393 0.0939 no no no no no dn 18:0/18:2-PC+blood UDCA+blood -0.478375363 0 0 yes serum_phospholipids serum_bileacids 1.74E-06 0.0939 no up up no no dn 18:0/20:2-PC+blood UDCA+blood 0 0 -0.480822623 yes serum_phospholipids serum_bileacids 0.733 0.0939 no no no no no dn 18:0/20:4-PC+blood UDCA+blood -0.500940239 0 0 yes serum_phospholipids serum_bileacids 0.454 0.0939 no no no no no dn 18:0/20:4-PI+blood UDCA+blood -0.525761602 0 0 yes serum_phospholipids serum_bileacids 0.167 0.0939 no no no no no dn 18:0/22:6-PA+blood UDCA+blood -0.631816517 0 0 yes serum_phospholipids serum_bileacids 0.22 0.0939 no no no no no dn 18:1-LPE+blood UDCA+blood 0.461075625 0 0 yes serum_phospholipids serum_bileacids 0.117 0.0939 no no no no no dn 18:1/18:0-PC+blood UDCA+blood -0.473862388 0 0 yes serum_phospholipids serum_bileacids 1.83E-06 0.0939 no up up no no dn 18:1/18:0-PS+blood UDCA+blood -0.730349807 0 0 yes serum_phospholipids serum_bileacids 0.193 0.0939 no no no no no dn 18:1/18:1-PG+blood UDCA+blood -0.4595713 0 0 yes serum_phospholipids serum_bileacids 0.00352 0.0939 no up up no no dn 18:1/18:2-PG+blood UDCA+blood -0.518992139 0 0 yes serum_phospholipids serum_bileacids 5.58E-07 0.0939 no up up no no dn 18:1/20:4-PE+blood UDCA+blood -0.508461864 0 0 yes serum_phospholipids serum_bileacids 0.0578 0.0939 up no no no no dn 18:2-LPA+blood UDCA+blood 0 -0.526057732 0 yes serum_phospholipids serum_bileacids 0.00684 0.0939 dn no up no no dn 18:3-LPC+blood UDCA+blood 0.639338142 0 0 yes serum_phospholipids serum_bileacids 0.147 0.0939 no no no no no dn 20:0/20:5-PC+blood UDCA+blood -0.634073005 0 0 yes serum_phospholipids serum_bileacids 0.882 0.0939 no no no no no dn 20:1-LPC+blood UDCA+blood 0 0 -0.406849912 yes serum_phospholipids serum_bileacids 0.217 0.0939 no no no no no dn 20:1/20:4-PE+blood UDCA+blood -0.543813502 0 0 yes serum_phospholipids serum_bileacids 0.0042 0.0939 up up no no no dn 20:2+blood UDCA+blood 0 0 -0.57157618 yes serum_fattyacid serum_bileacids 0.478 0.0939 no no no no no dn 20:3/18:0-PC+blood UDCA+blood -0.561865403 0 0 yes serum_phospholipids serum_bileacids 0.296 0.0939 no no no no no dn 20:3/18:0-PI+blood UDCA+blood -0.495675101 0 0 yes serum_phospholipids serum_bileacids 0.289 0.0939 no no no no no dn 20:4-LPA+blood UDCA+blood -0.4776232 0 -0.452397924 yes serum_phospholipids serum_bileacids 0.398 0.0939 no no no no no dn 20:4/18:0-PE+blood UDCA+blood -0.594960554 0 0 yes serum_phospholipids serum_bileacids 0.000755 0.0939 up up no no no dn 24:0+blood UDCA+blood 0 0 0.417808832 yes serum_fattyacid serum_bileacids 0.034 0.0939 dn no up no no dn AA+blood UDCA+blood -0.504701051 0 0 yes serum_ARA serum_bileacids 0.212 0.0939 no no no no no dn acetic acid C2+blood UDCA+blood -0.510718351 0 0 yes serum_scfa serum_bileacids 0.000193 0.0939 up dn no no no dn Acute myeloid leukemia UDCA+blood 0 -0.637233432 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn AGE-RAGE signaling pathway in diabetic complications UDCA+blood 0 -0.737307043 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Aldosterone synthesis and secretion UDCA+blood 0 0.575423261 0 yes kegg serum_bileacids NA 0.0939 no up up no no dn Alzheimer disease UDCA+blood 0 0.649006798 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Amoebiasis UDCA+blood 0 -0.610743359 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Amphetamine addiction UDCA+blood 0 0.619573383 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Amyotrophic lateral sclerosis UDCA+blood 0 0.707873628 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Anaerostipes UDCA+blood 0 0.528576353 0 butyrate-producing yes Genus serum_bileacids 0.568 0.0939 no no no no no dn Apelin signaling pathway UDCA+blood 0 0.656365152 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Apoptosis UDCA+blood 0 -0.528329797 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Arginine and proline metabolism UDCA+blood 0 -0.769683799 0 yes kegg serum_bileacids NA 0.0939 no up no no no dn Autophagy - animal UDCA+blood 0 -0.631346749 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn B cell receptor signaling pathway UDCA+blood 0 -0.540103163 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Biosynthesis of amino acids UDCA+blood 0 -0.634290091 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Bladder cancer UDCA+blood 0 -0.721118665 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Breast cancer UDCA+blood 0 -0.526858126 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn C-type lectin receptor signaling pathway UDCA+blood 0 -0.578366602 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn CA+blood UDCA+blood 0.616629044 0.487730061 0.529210403 yes serum_bileacids serum_bileacids 0.606 0.0939 no no no no no dn Cardiac muscle contraction UDCA+blood 0 0.643120115 0 yes kegg serum_bileacids NA 0.0939 no no up no no dn CDCA+blood UDCA+blood 0.843174185 0.78356851 0.711987345 yes serum_bileacids serum_bileacids 0.506 0.0939 no no no no no dn Cell cycle UDCA+blood 0 0.582781615 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn cGMP-PKG signaling pathway UDCA+blood 0 -0.678440213 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Chagas disease UDCA+blood 0 -0.551876529 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Chemokine signaling pathway UDCA+blood 0 -0.51361309 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Coronavirus disease - COVID-19 UDCA+blood 0 0.644591786 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn d18:1-18:0-SM+blood UDCA+blood -0.563369728 0 0 yes serum_phospholipids serum_bileacids 0.97 0.0939 no no no no no dn d18:1-18:1-SM+blood UDCA+blood -0.528770252 0 0 yes serum_phospholipids serum_bileacids 0.916 0.0939 no no no no no dn DCA+blood UDCA+blood 0.73110197 0 0.462329445 yes serum_bileacids serum_bileacids 0.122 0.0939 no no no no no dn Diabetic cardiomyopathy UDCA+blood 0 0.634290091 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn EGFR tyrosine kinase inhibitor resistance UDCA+blood 0 0.616630042 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Epithelial cell signaling in Helicobacter pylori infection UDCA+blood 0 -0.707873628 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Fc epsilon RI signaling pathway UDCA+blood 0 -0.788815519 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Fc gamma R-mediated phagocytosis UDCA+blood 0 -0.744665397 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn GABAergic synapse UDCA+blood 0 -0.75055208 0 yes kegg serum_bileacids NA 0.0939 no up up no no dn GCA+blood UDCA+blood 0.518239976 0 0 yes yes serum_bileacids serum_bileacids 0.16 0.0939 no no no no no dn GCDCA+blood UDCA+blood 0.661903018 0 0 yes serum_bileacids serum_bileacids 0.31 0.0939 no no no no no dn Glucagon signaling pathway UDCA+blood 0 0.681383555 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Glutamatergic synapse UDCA+blood 0 -0.631346749 0 yes kegg serum_bileacids NA 0.0939 no up up no no dn Glycine+blood UDCA+blood 0 -0.543225117 0 yes serum_aminoacids serum_bileacids 0.00408 0.0939 dn no up no no dn Glycolysis / Gluconeogenesis UDCA+blood 0 0.501839724 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn GPC+blood UDCA+blood 0 0 -0.414384169 yes serum_choline serum_bileacids 0.00427 0.0939 no up up no no dn GUDCA+blood UDCA+blood 0.748401708 0.72225642 0.553425469 yes serum_bileacids serum_bileacids 0.0766 0.0939 no no dn no no dn HCA+blood UDCA+blood 0.703565162 0.552757022 0.494849777 yes serum_bileacids serum_bileacids 0.544 0.0939 no no no no no dn HCA+stool UDCA+blood 0 0 0.507928145 yes stool_bileacids serum_bileacids 0.155 0.0939 no no no no no dn Hepatitis B UDCA+blood 0 -0.621045054 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn HIF-1 signaling pathway UDCA+blood 0 0.629875079 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Hippo signaling pathway UDCA+blood 0 0.540103163 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Huntington disease UDCA+blood 0 0.65342181 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn IL-17 signaling pathway UDCA+blood 0 -0.693156921 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Inflammatory mediator regulation of TRP channels UDCA+blood 0 0.63281842 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Insulin signaling pathway UDCA+blood 0 0.687270238 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Intestinal immune network for IgA production UDCA+blood 0 0 -0.401847694 yes kegg serum_bileacids NA 0.0939 no no no no no dn iso-LCA+stool UDCA+blood 0 0 -0.458116469 yes stool_bileacids serum_bileacids 0.72 0.0939 no no no no no dn isovaleric acid iso-C5+blood UDCA+blood 0 0 -0.449315727 yes serum_scfa serum_bileacids 0.117 0.0939 no no no no no dn L-Phenylalanine+stool UDCA+blood 0 -0.76993366 0 yes stool_cometabolism serum_bileacids 0.398 0.0939 no no no no no dn L-Tryptophan+stool UDCA+blood -0.572215122 0 0 yes stool_cometabolism serum_bileacids 0.557 0.0939 no no no no no dn L-Tyrosine+stool UDCA+blood 0 -0.779045301 0 yes stool_cometabolism serum_bileacids 0.44 0.0939 no no no no no dn Lipid and atherosclerosis UDCA+blood 0 -0.676968542 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Long-term potentiation UDCA+blood 0 0.545989846 0 yes kegg serum_bileacids NA 0.0939 no no up no no dn Lysosome UDCA+blood 0 -0.598969993 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Melanogenesis UDCA+blood 0 0.61221503 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn mRNA surveillance pathway UDCA+blood 0 0.604856676 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn mTOR signaling pathway UDCA+blood 0 0.581309944 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Neuroactive ligand-receptor interaction UDCA+blood 0 -0.537159822 0 yes kegg serum_bileacids NA 0.0939 up up up no no dn Neutrophil extracellular trap formation UDCA+blood 0 -0.679911884 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn NF-kappa B signaling pathway UDCA+blood 0 -0.545989846 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Nicotinate and nicotinamide metabolism UDCA+blood 0 -0.822663946 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn NOD-like receptor signaling pathway UDCA+blood 0 -0.638705103 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Non-alcoholic fatty liver disease UDCA+blood 0 0.556291541 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn nutriCA+blood UDCA+blood 0.66722259 0.662335497 0.533796474 yes serum_bileacids serum_bileacids 0.726 0.0939 no no no no no dn nutriCA+stool UDCA+blood 0 0 0.483777029 yes stool_bileacids serum_bileacids 0.481 0.0939 no no no no no dn Olfactory transduction UDCA+blood 0 -0.654893481 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Oocyte meiosis UDCA+blood 0 0.582781615 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Osteoclast differentiation UDCA+blood 0 -0.694628591 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Oxidative phosphorylation UDCA+blood 0 0.628403408 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Parabacteroides UDCA+blood -0.4655886 0 0 yes Genus serum_bileacids 4.19E-05 0.0939 no up up no no dn Parkinson disease UDCA+blood 0 0.565121566 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Pathways of neurodegeneration - multiple diseases UDCA+blood 0 0.565121566 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Peroxisome UDCA+blood 0 -0.665195176 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Pertussis UDCA+blood 0 -0.625460066 0 yes kegg serum_bileacids NA 0.0939 no no dn no no dn Phenylacetic acid+stool UDCA+blood 0 -0.633259046 0 yes stool_cometabolism serum_bileacids 0.785 0.0939 no no no no no dn Phospholipase D signaling pathway UDCA+blood 0 -0.682855225 0 yes kegg serum_bileacids NA 0.0939 no up up no no dn PPAR signaling pathway UDCA+blood 0 -0.727005348 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Prion disease UDCA+blood 0 0.65195014 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Prolactin signaling pathway UDCA+blood 0 -0.678440213 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Proteasome UDCA+blood 0 0.525386456 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Protein processing in endoplasmic reticulum UDCA+blood 0 0.699043604 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Proteoglycans in cancer UDCA+blood 0 0.619573383 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Ras signaling pathway UDCA+blood 0 0.547461517 0 yes yes kegg serum_bileacids NA 0.0939 no up up no no dn Renin secretion UDCA+blood 0 0.634290091 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Retrograde endocannabinoid signaling UDCA+blood 0 0.616630042 0 yes kegg serum_bileacids NA 0.0939 no no up no no dn Rheumatoid arthritis UDCA+blood 0 -0.500368053 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Ribosome UDCA+blood 0 0.644591786 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Ribosome biogenesis in eukaryotes UDCA+blood 0 0.615158371 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn RIG-I-like receptor signaling pathway UDCA+blood 0 -0.566593237 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn RNA degradation UDCA+blood 0 0.813833922 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn RNA transport UDCA+blood 0 0.579838273 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Sphingolipid signaling pathway UDCA+blood 0 -0.520971443 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Spinocerebellar ataxia UDCA+blood 0 0.622516725 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Staphylococcus aureus infection UDCA+blood 0 -0.5533482 0 yes kegg serum_bileacids NA 0.0939 up no no no no dn Systemic lupus erythematosus UDCA+blood 0 -0.575423261 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn T-a-MCA+blood UDCA+blood 0 0 -0.417123849 yes serum_bileacids serum_bileacids 0.478 0.0939 no no no no no dn Thermogenesis UDCA+blood 0 0.662251835 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Toll-like receptor signaling pathway UDCA+blood 0 -0.678440213 0 yes yes kegg serum_bileacids NA 0.0939 no no no no no dn Transcriptional misregulation in cancer UDCA+blood 0 -0.520971443 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Tuberculosis UDCA+blood 0 -0.619573383 0 yes kegg serum_bileacids NA 0.0939 no no dn no no dn Ubiquitin mediated proteolysis UDCA+blood 0 0.538631492 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn UDCA+stool UDCA+blood 0 0 0.564532321 yes stool_bileacids serum_bileacids 0.266 0.0939 no no no no no dn Wnt signaling pathway UDCA+blood 0 0.681383555 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn Yersinia infection UDCA+blood 0 -0.563649895 0 yes kegg serum_bileacids NA 0.0939 no no no no no dn 3-(3-Hydroxyphenyl)propanoic acid+stool UDCA+stool 0 0 0.432806324 stool_cometabolism stool_bileacids 0.33 0.266 no no no no no no 5-Hydroxytryptamine+stool UDCA+stool 0 -0.615384615 0 stool_cometabolism stool_bileacids 0.00862 0.266 dn dn no no no no Adipocytokine signaling pathway UDCA+stool 0 0 -0.526821005 kegg stool_bileacids NA 0.266 no no no no no no Allograft rejection UDCA+stool 0 0.690909091 0 kegg stool_bileacids NA 0.266 no no no no no no Alzheimer disease UDCA+stool 0 0 0.607001694 kegg stool_bileacids NA 0.266 no no no no no no AMPK signaling pathway UDCA+stool 0 0 -0.602484472 kegg stool_bileacids NA 0.266 no no no no no no Amyotrophic lateral sclerosis UDCA+stool 0 0 0.613777527 kegg stool_bileacids NA 0.266 no no no no no no Antigen processing and presentation UDCA+stool 0.51496388 0.636363636 0 kegg stool_bileacids NA 0.266 no no no no no no Autoimmune thyroid disease UDCA+stool 0 0.690909091 0 kegg stool_bileacids NA 0.266 no no no no no no Bacteroides UDCA+stool 0.471620227 0 0 LPS-producing Genus stool_bileacids 0.000267 0.266 dn dn up no no no Blautia UDCA+stool 0 0.832167832 0 acetate-producing Genus stool_bileacids 1.36E-05 0.266 up dn dn no no no CA+stool UDCA+stool 0.651186791 0.86013986 0.751976285 stool_bileacids stool_bileacids 0.827 0.266 no no no no no no Carbon metabolism UDCA+stool 0 0.672727273 0 kegg stool_bileacids NA 0.266 no no no no no no Cardiac muscle contraction UDCA+stool 0 0 0.63297572 kegg stool_bileacids NA 0.266 no no up no no no CDCA+stool UDCA+stool 0.750257998 0.909090909 0.801383399 stool_bileacids stool_bileacids 0.663 0.266 no no no no no no Cell adhesion molecules UDCA+stool 0 0.654545455 0 kegg stool_bileacids NA 0.266 no no no no no no Cellular senescence UDCA+stool 0 0.627272727 0.425183512 kegg stool_bileacids NA 0.266 no no no no no no Chemical carcinogenesis - receptor activation UDCA+stool 0 -0.709090909 -0.445511011 kegg stool_bileacids NA 0.266 no no no no no no Clostridium UDCA+stool 0 0.601398601 0 Genus stool_bileacids 0.925 0.266 no no no no no no Cocaine addiction UDCA+stool 0 -0.663636364 0 kegg stool_bileacids NA 0.266 no no no no no no Coronavirus disease - COVID-19 UDCA+stool -0.479876161 0 0 kegg stool_bileacids NA 0.266 no no no no no no Cortisol synthesis and secretion UDCA+stool 0 -0.718181818 0 kegg stool_bileacids NA 0.266 no no up no no no Cushing syndrome UDCA+stool -0.539731682 0 0 kegg stool_bileacids NA 0.266 no no up no no no Diabetic cardiomyopathy UDCA+stool 0 0 0.584415584 kegg stool_bileacids NA 0.266 no no no no no no Dorea UDCA+stool 0 0.79020979 0 Genus stool_bileacids 0.00362 0.266 up no dn no no no Endocrine resistance UDCA+stool 0 -0.781818182 -0.508752117 kegg stool_bileacids NA 0.266 no no no no no no Epithelial cell signaling in Helicobacter pylori infection UDCA+stool 0.5500516 0 0 kegg stool_bileacids NA 0.266 no no no no no no Epstein-Barr virus infection UDCA+stool 0.490196078 0 0 kegg stool_bileacids NA 0.266 no no no no no no FoxO signaling pathway UDCA+stool 0 0 -0.461321287 kegg stool_bileacids NA 0.266 no no no no no no GABAergic synapse UDCA+stool 0 0 -0.428571429 kegg stool_bileacids NA 0.266 no up up no no no Gap junction UDCA+stool 0 -0.672727273 0 kegg stool_bileacids NA 0.266 no no no no no no GCA+stool UDCA+stool 0 0.846153846 0 stool_bileacids stool_bileacids 0.0809 0.266 no no no no no no GCDCA+stool UDCA+stool 0 0.685314685 0 yes stool_bileacids stool_bileacids 0.0471 0.266 no dn no no no no GDCA+stool UDCA+stool 0 0.756568586 0 stool_bileacids stool_bileacids 0.656 0.266 no no no no no no Glutamatergic synapse UDCA+stool 0 -0.654545455 -0.445511011 kegg stool_bileacids NA 0.266 no up up no no no GnRH signaling pathway UDCA+stool 0 -0.718181818 0 kegg stool_bileacids NA 0.266 no no no no no no Graft-versus-host disease UDCA+stool 0 0.690909091 0 kegg stool_bileacids NA 0.266 no no no no no no "Growth hormone synthesis, secretion and action" UDCA+stool 0 -0.763636364 -0.422924901 kegg stool_bileacids NA 0.266 no no no no no no HCA+stool UDCA+stool 0.834881321 0 0.624505929 stool_bileacids stool_bileacids 0.155 0.266 no no no no no no Hepatitis C UDCA+stool 0 0 -0.425183512 kegg stool_bileacids NA 0.266 no no no no no no Hepatocellular carcinoma UDCA+stool 0 0 0.440993789 kegg stool_bileacids NA 0.266 no no no no no no Herpes simplex virus 1 infection UDCA+stool 0 0.654545455 0 kegg stool_bileacids NA 0.266 no no no no no no Human T-cell leukemia virus 1 infection UDCA+stool 0 0.609090909 0 kegg stool_bileacids NA 0.266 no no no no no no Huntington disease UDCA+stool 0 0 0.543760587 kegg stool_bileacids NA 0.266 no no no no no no IL-17 signaling pathway UDCA+stool 0.475748194 0 0 kegg stool_bileacids NA 0.266 no no no no no no Indole-3-Acetic acid+stool UDCA+stool 0 -0.755244755 0 stool_cometabolism stool_bileacids 0.304 0.266 no no no no no no Insulin secretion UDCA+stool 0 -0.609090909 0 yes kegg stool_bileacids NA 0.266 no up up no no no iso-DCA+stool UDCA+stool -0.572755418 0 0 stool_bileacids stool_bileacids 0.155 0.266 no no no no no no iso-LCA+stool UDCA+stool -0.658750733 -0.629370629 -0.726284585 stool_bileacids stool_bileacids 0.72 0.266 no no no no no no Isobutyric acid+stool UDCA+stool 0 -0.776223776 -0.468379447 stool_scfa stool_bileacids 0.408 0.266 no no no no no no Isovaleric acid+stool UDCA+stool 0 -0.636363636 -0.479249012 stool_scfa stool_bileacids 0.343 0.266 no no no no no no Kynurenic acid+stool UDCA+stool -0.609907121 0 -0.431818182 stool_cometabolism stool_bileacids 0.037 0.266 dn dn no no no no L-Phenylalanine+stool UDCA+stool 0 0 -0.493083004 stool_cometabolism stool_bileacids 0.398 0.266 no no no no no no L-Tyrosine+stool UDCA+stool 0 0 -0.482213439 stool_cometabolism stool_bileacids 0.44 0.266 no no no no no no LCA+stool UDCA+stool 0 -0.601398601 -0.442687747 stool_bileacids stool_bileacids 0.314 0.266 no no no no no no Lipid and atherosclerosis UDCA+stool 0.502579979 0 0 kegg stool_bileacids NA 0.266 no no no no no no Longevity regulating pathway UDCA+stool 0 -0.681818182 -0.531338227 kegg stool_bileacids NA 0.266 no no no no no no Lysosome UDCA+stool 0.512899897 0 0 kegg stool_bileacids NA 0.266 no no no no no no Malaria UDCA+stool 0 0 -0.446640316 kegg stool_bileacids NA 0.266 no no no no no no Mitophagy - animal UDCA+stool 0 0 -0.442123094 kegg stool_bileacids NA 0.266 no no no no no no Natural killer cell mediated cytotoxicity UDCA+stool 0 0.627272727 0 kegg stool_bileacids NA 0.266 no no no no no no Neutrophil extracellular trap formation UDCA+stool 0.488132095 0 0 kegg stool_bileacids NA 0.266 no no no no no no Non-alcoholic fatty liver disease UDCA+stool 0 0 0.454545455 kegg stool_bileacids NA 0.266 no no no no no no nutriCA+stool UDCA+stool 0.857585139 0.64790339 0.867588933 stool_bileacids stool_bileacids 0.481 0.266 no no no no no no Oxidative phosphorylation UDCA+stool 0 0 0.574251835 kegg stool_bileacids NA 0.266 no no no no no no p53 signaling pathway UDCA+stool 0 -0.618181818 0 kegg stool_bileacids NA 0.266 no no no no no no Pathways in cancer UDCA+stool 0 0 -0.511010728 kegg stool_bileacids NA 0.266 no no no no no no Pertussis UDCA+stool 0.760577915 0 0 kegg stool_bileacids NA 0.266 no no dn no no no Phenylacetic acid+stool UDCA+stool 0 0 -0.434782609 stool_cometabolism stool_bileacids 0.785 0.266 no no no no no no Prion disease UDCA+stool 0 0 0.561829475 kegg stool_bileacids NA 0.266 no no no no no no Proteasome UDCA+stool 0 0.745454545 0 kegg stool_bileacids NA 0.266 no no no no no no Proteoglycans in cancer UDCA+stool 0 0 0.450028233 kegg stool_bileacids NA 0.266 no no no no no no Purine metabolism UDCA+stool 0 0 -0.497459063 kegg stool_bileacids NA 0.266 no no no no no no Regulation of actin cytoskeleton UDCA+stool 0 0 0.472614342 kegg stool_bileacids NA 0.266 no no no no no no Regulation of lipolysis in adipocytes UDCA+stool 0 -0.609090909 0 kegg stool_bileacids NA 0.266 no no no no no no Retrograde endocannabinoid signaling UDCA+stool 0 0 0.679277244 kegg stool_bileacids NA 0.266 no no up no no no Ribosome UDCA+stool -0.475748194 0 0 kegg stool_bileacids NA 0.266 no no no no no no Salmonella infection UDCA+stool 0 0.636363636 0 kegg stool_bileacids NA 0.266 no no no no no no Serotonergic synapse UDCA+stool 0 -0.836363636 0 kegg stool_bileacids NA 0.266 no no no no no no Signaling pathways regulating pluripotency of stem cells UDCA+stool -0.539731682 0 0 kegg stool_bileacids NA 0.266 no no no no no no Staphylococcus aureus infection UDCA+stool 0.521155831 0 0 kegg stool_bileacids NA 0.266 up no no no no no Systemic lupus erythematosus UDCA+stool 0.523219814 0 0 kegg stool_bileacids NA 0.266 no no no no no no T-¦Á-MCA+stool UDCA+stool 0 -0.715957986 0 stool_bileacids stool_bileacids 0.48 0.266 no no no no no no TDCA+stool UDCA+stool 0 0 0.468993666 stool_bileacids stool_bileacids 0.963 0.266 no no no no no no Thermogenesis UDCA+stool 0 0 0.520045172 kegg stool_bileacids NA 0.266 no no no no no no Thyroid hormone signaling pathway UDCA+stool 0 0 0.43308865 kegg stool_bileacids NA 0.266 no no no no no no TUDCA+stool UDCA+stool 0 0 -0.715916838 stool_bileacids stool_bileacids 0.241 0.266 no no no no no no Type I diabetes mellitus UDCA+stool 0 0.690909091 0 kegg stool_bileacids NA 0.266 no no no no no no Viral myocarditis UDCA+stool 0 0.690909091 0.439864483 kegg stool_bileacids NA 0.266 no no no no no no Wnt signaling pathway UDCA+stool 0 0 0.424054207 kegg stool_bileacids NA 0.266 no no no no no no 12-ketoDCA+blood UFA%+blood -0.496889108 0 0 serum_bileacids serum_fattyacid 0.517 0.0236 no no no no dn no 13-HODE+blood UFA%+blood 0 0.507352941 0 serum_ARA serum_fattyacid 0.32 0.0236 no no no no dn no 14:0/20:4-PC+blood UFA%+blood 0 0 -0.425641026 serum_phospholipids serum_fattyacid 0.486 0.0236 no no no no dn no 14:1/18:2-PG+blood UFA%+blood 0 0 -0.433846154 serum_phospholipids serum_fattyacid 0.00259 0.0236 no up up no dn no 16:0/14:0-PC+blood UFA%+blood 0 0 0.456410256 serum_phospholipids serum_fattyacid 0.0206 0.0236 no up up no dn no 16:0/16:0-PC+blood UFA%+blood 0.464661654 0 0 serum_phospholipids serum_fattyacid 0.00079 0.0236 no up up no dn no 16:0/16:0-PI+blood UFA%+blood -0.642105263 0 -0.457094017 serum_phospholipids serum_fattyacid 0.358 0.0236 no no no no dn no 16:0/16:1-PI+blood UFA%+blood -0.783458647 0 -0.474188034 serum_phospholipids serum_fattyacid 0.262 0.0236 no no no no dn no 16:0/18:1-PC+blood UFA%+blood 0.703759398 0 0.424957265 serum_phospholipids serum_fattyacid 6.15E-07 0.0236 up up up no dn no 16:0/18:1-PE+blood UFA%+blood -0.532330827 0 0 serum_phospholipids serum_fattyacid 0.000107 0.0236 up up no no dn no 16:0/18:2-PC+blood UFA%+blood 0.706766917 0.654411765 0.634871795 serum_phospholipids serum_fattyacid 3.24E-06 0.0236 no up up no dn no 16:0/18:2-PI+blood UFA%+blood -0.566917293 0 -0.433162393 serum_phospholipids serum_fattyacid 0.269 0.0236 no no no no dn no 16:0/20:3-PC+blood UFA%+blood 0.687218045 0 0.472136752 serum_phospholipids serum_fattyacid 5.43E-06 0.0236 no up up no dn no 16:0/20:4-PC+blood UFA%+blood 0.560902256 0 0 serum_phospholipids serum_fattyacid 0.0262 0.0236 no up no no dn no 16:0/20:4-PI+blood UFA%+blood -0.729323308 0 -0.546666667 serum_phospholipids serum_fattyacid 0.558 0.0236 no no no no dn no 16:0/22:0-PE+blood UFA%+blood 0 0 0.503589744 serum_phospholipids serum_fattyacid 0.00839 0.0236 dn no up no dn no 16:0/22:6-PC+blood UFA%+blood 0.515789474 0 0.651965812 serum_phospholipids serum_fattyacid 4.53E-05 0.0236 no up up no dn no 16:1/16:0-PC+blood UFA%+blood 0.676691729 0 0.447521368 serum_phospholipids serum_fattyacid 0.0215 0.0236 no up up no dn no 16:1/16:1-PC+blood UFA%+blood 0.577443609 0 0 serum_phospholipids serum_fattyacid 0.0177 0.0236 no no up no dn no 16:1/18:2-PG+blood UFA%+blood 0.521804511 0 0 serum_phospholipids serum_fattyacid 1.40E-08 0.0236 no up up no dn no 18:0-LPA+blood UFA%+blood 0 0.669117647 0 serum_phospholipids serum_fattyacid 0.0725 0.0236 no dn no no dn no 18:0/16:0-PC+blood UFA%+blood 0.691729323 0 0.406495726 serum_phospholipids serum_fattyacid 9.64E-07 0.0236 up up up no dn no 18:0/18:0-PE+blood UFA%+blood -0.646616541 0 -0.472820513 serum_phospholipids serum_fattyacid 0.00896 0.0236 up up no no dn no 18:0/18:1-PE+blood UFA%+blood -0.679699248 0 -0.484444444 serum_phospholipids serum_fattyacid 0.00716 0.0236 up up no no dn no 18:0/18:1-PG+blood UFA%+blood 0 0 -0.673846154 serum_phospholipids serum_fattyacid 0.000842 0.0236 no up no no dn no 18:0/18:2-PC+blood UFA%+blood 0.693233083 0 0.667692308 serum_phospholipids serum_fattyacid 1.74E-06 0.0236 no up up no dn no 18:0/20:4-PC+blood UFA%+blood 0.527819549 0 0 serum_phospholipids serum_fattyacid 0.454 0.0236 no no no no dn no 18:0/20:5-PC+blood UFA%+blood 0.536842105 0 0 serum_phospholipids serum_fattyacid 0.17 0.0236 no no no no dn no 18:1/16:0-PC+blood UFA%+blood 0.697744361 0.642156863 0.651965812 serum_phospholipids serum_fattyacid 2.43E-05 0.0236 no up up no dn no 18:1/16:0-PE+blood UFA%+blood -0.640601504 0 -0.519316239 serum_phospholipids serum_fattyacid 0.000182 0.0236 up up no no dn no 18:1/16:0-PI+blood UFA%+blood -0.630075188 0 0 serum_phospholipids serum_fattyacid 0.793 0.0236 no no no no dn no 18:1/16:1-PE+blood UFA%+blood -0.583458647 0 0 serum_phospholipids serum_fattyacid 0.000184 0.0236 up up no no dn no 18:1/18:0-PC+blood UFA%+blood 0.687218045 0 0.656752137 serum_phospholipids serum_fattyacid 1.83E-06 0.0236 no up up no dn no 18:1/18:0-PI+blood UFA%+blood 0 -0.514705882 0 serum_phospholipids serum_fattyacid 0.0931 0.0236 no no up no dn no 18:1/18:1-PC+blood UFA%+blood 0.566917293 0 0.436581197 serum_phospholipids serum_fattyacid 1.34E-05 0.0236 no up up no dn no 18:1/18:2-PE+blood UFA%+blood 0 0 -0.471452991 serum_phospholipids serum_fattyacid 0.000293 0.0236 up up no no dn no 18:1/18:2-PG+blood UFA%+blood 0.503759398 0 0 serum_phospholipids serum_fattyacid 5.58E-07 0.0236 no up up no dn no 18:1/20:4-PC+blood UFA%+blood 0.467669173 0 0 serum_phospholipids serum_fattyacid 0.582 0.0236 no no no no dn no 18:1/22:6-PE+blood UFA%+blood 0 0 0.405128205 serum_phospholipids serum_fattyacid 0.0047 0.0236 no up no no dn no 18:2-LPA+blood UFA%+blood 0 0.482843137 0 serum_phospholipids serum_fattyacid 0.00684 0.0236 dn no up no dn no 18:2/16:0-PC+blood UFA%+blood 0.729323308 0 0.434529915 serum_phospholipids serum_fattyacid 8.67E-05 0.0236 no up up no dn no 18:3/16:0-PE+blood UFA%+blood -0.562406015 0 -0.655384615 serum_phospholipids serum_fattyacid 0.00149 0.0236 up up no no dn no 18:3n3+blood UFA%+blood 0.452631579 0 0 serum_fattyacid serum_fattyacid 0.291 0.0236 no no no no dn no 18:3n6+blood UFA%+blood -0.541353383 -0.50245098 -0.446153846 serum_fattyacid serum_fattyacid 0.0463 0.0236 up no dn no dn no 20:0/20:4-PE+blood UFA%+blood 0 -0.519607843 -0.456410256 serum_phospholipids serum_fattyacid 0.00128 0.0236 up up no no dn no 20:1-LPA+blood UFA%+blood 0 0.566176471 0 serum_phospholipids serum_fattyacid 0.0187 0.0236 dn dn no no dn no 20:1/20:4-PC+blood UFA%+blood 0 0 0.437948718 serum_phospholipids serum_fattyacid 0.0419 0.0236 no no up no dn no 20:1/20:4-PE+blood UFA%+blood 0 0 -0.455726496 serum_phospholipids serum_fattyacid 0.0042 0.0236 up up no no dn no 20:2-LPC+blood UFA%+blood 0 0 0.410598291 serum_phospholipids serum_fattyacid 0.119 0.0236 no no up no dn no 20:2/18:1-PE+blood UFA%+blood -0.460150376 0 0 serum_phospholipids serum_fattyacid 0.00208 0.0236 up up no no dn no 20:2+blood UFA%+blood 0 0 0.486495726 serum_fattyacid serum_fattyacid 0.478 0.0236 no no no no dn no 20:3/16:0-PC+blood UFA%+blood 0.586466165 0 0 serum_phospholipids serum_fattyacid 0.00405 0.0236 no up up no dn no 20:3/18:0-PC+blood UFA%+blood 0 0 0.497435897 serum_phospholipids serum_fattyacid 0.296 0.0236 no no no no dn no 20:4-LPA+blood UFA%+blood 0 0.519607843 0 serum_phospholipids serum_fattyacid 0.398 0.0236 no no no no dn no 20:4/16:0-PE+blood UFA%+blood -0.458646617 0 -0.498803419 serum_phospholipids serum_fattyacid 0.00529 0.0236 no up up no dn no 20:5/18:0-PC+blood UFA%+blood 0.517293233 0 0.72034188 serum_phospholipids serum_fattyacid 3.97E-06 0.0236 no up up no dn no 22:0/16:0-PE+blood UFA%+blood 0 0 0.502905983 serum_phospholipids serum_fattyacid 0.091 0.0236 no no up no dn no 22:1-LPA+blood UFA%+blood 0 0.546568627 0 serum_phospholipids serum_fattyacid 0.00373 0.0236 no up up no dn no 22:6n3+blood UFA%+blood 0 0 0.412649573 serum_fattyacid serum_fattyacid 0.792 0.0236 no no no no dn no 24:1+blood UFA%+blood 0 0 0.482393162 serum_fattyacid serum_fattyacid 0.00582 0.0236 no dn dn no dn no 5-HETE+blood UFA%+blood 0.492078975 0 0 serum_ARA serum_fattyacid 0.697 0.0236 no no no no dn no AA+blood UFA%+blood 0.533834586 0 0 serum_ARA serum_fattyacid 0.212 0.0236 no no no no dn no ACA+stool UFA%+blood 0.566955362 0 0 stool_bileacids serum_fattyacid 0.417 0.0236 no no no no dn no Acetic acid+stool UFA%+blood 0 0 -0.463157895 yes stool_scfa serum_fattyacid 0.0656 0.0236 dn no no no dn no Adrenergic signaling in cardiomyocytes UFA%+blood 0 -0.655882353 -0.44 kegg serum_fattyacid NA 0.0236 no no up no dn no AGE-RAGE signaling pathway in diabetic complications UFA%+blood 0 0.629411765 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Aldosterone synthesis and secretion UFA%+blood 0 -0.691176471 0 kegg serum_fattyacid NA 0.0236 no up up no dn no Allograft rejection UFA%+blood 0 0.588235294 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Alzheimer disease UFA%+blood 0 -0.591176471 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Amoebiasis UFA%+blood 0 0.617647059 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Amphetamine addiction UFA%+blood 0 -0.688235294 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Amyotrophic lateral sclerosis UFA%+blood 0 -0.608823529 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Apelin signaling pathway UFA%+blood 0 -0.685294118 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Apoptosis UFA%+blood 0 0.6 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Autoimmune thyroid disease UFA%+blood 0 0.588235294 0 kegg serum_fattyacid NA 0.0236 no no no no dn no B cell receptor signaling pathway UFA%+blood 0.494736842 0 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Betaine+blood UFA%+blood 0 0 0.484444444 serum_choline serum_fattyacid 0.857 0.0236 no no no no dn no Biosynthesis of amino acids UFA%+blood 0 0.702941176 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Bladder cancer UFA%+blood 0 0.629411765 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Breast cancer UFA%+blood 0 0 -0.443846154 kegg serum_fattyacid NA 0.0236 no no no no dn no Butyricimonas UFA%+blood 0 -0.497776273 0 butyrate-producing Genus serum_fattyacid 0.17 0.0236 no no no no dn no C-type lectin receptor signaling pathway UFA%+blood 0 0.535294118 0 kegg serum_fattyacid NA 0.0236 no no no no dn no CA+blood UFA%+blood 0 -0.532188941 -0.435337038 serum_bileacids serum_fattyacid 0.606 0.0236 no no no no dn no Calcium signaling pathway UFA%+blood 0 0 -0.496923077 kegg serum_fattyacid NA 0.0236 no up up no dn no capric acid C6+blood UFA%+blood 0 0 0.532307692 serum_scfa serum_fattyacid 0.433 0.0236 no no no no dn no Carbon metabolism UFA%+blood 0 0 0.488461538 kegg serum_fattyacid NA 0.0236 no no no no dn no Cardiac muscle contraction UFA%+blood 0 -0.570588235 -0.415384615 kegg serum_fattyacid NA 0.0236 no no up no dn no CDCA+blood UFA%+blood 0 -0.556372549 0 serum_bileacids serum_fattyacid 0.506 0.0236 no no no no dn no Cell adhesion molecules UFA%+blood 0 0.620588235 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Cell cycle UFA%+blood 0 -0.723529412 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Cellular senescence UFA%+blood 0 0.658823529 0 kegg serum_fattyacid NA 0.0236 no no no no dn no cGMP-PKG signaling pathway UFA%+blood 0 0.623529412 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Chemical carcinogenesis - receptor activation UFA%+blood 0 -0.526470588 -0.470769231 kegg serum_fattyacid NA 0.0236 no no no no dn no Chemokine signaling pathway UFA%+blood 0 0.523529412 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Choline metabolism in cancer UFA%+blood 0 0 -0.450769231 kegg serum_fattyacid NA 0.0236 no no no no dn no Colorectal cancer UFA%+blood 0 -0.561764706 -0.479230769 kegg serum_fattyacid NA 0.0236 no no no no dn no Coronavirus disease - COVID-19 UFA%+blood 0 -0.658823529 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Cortisol synthesis and secretion UFA%+blood 0 0 -0.498461538 kegg serum_fattyacid NA 0.0236 no no up no dn no Creatinine+blood UFA%+blood 0.535338346 0.517156863 0.516581197 serum_choline serum_fattyacid 0.437 0.0236 no no no no dn no Cushing syndrome UFA%+blood 0 -0.614705882 -0.541538462 kegg serum_fattyacid NA 0.0236 no no up no dn no Cysteine+blood UFA%+blood 0.464661654 0.644607843 0.548717949 yes serum_aminoacids serum_fattyacid 1.81E-07 0.0236 dn up up no dn no Cystine+blood UFA%+blood 0.457142857 0.700980392 0.486495726 yes serum_aminoacids serum_fattyacid 0.00028 0.0236 up up no no dn no d18:1-14:0-SM+blood UFA%+blood 0 -0.590686275 -0.433162393 serum_phospholipids serum_fattyacid 0.94 0.0236 no no no no dn no d18:1-14:1-SM+blood UFA%+blood 0 -0.585784314 -0.416752137 serum_phospholipids serum_fattyacid 0.0952 0.0236 no dn no no dn no d18:1-16:1-SM+blood UFA%+blood 0 -0.536764706 -0.474871795 serum_phospholipids serum_fattyacid 0.2 0.0236 no no no no dn no d18:1-18:0-SM+blood UFA%+blood 0.636090226 0 0 serum_phospholipids serum_fattyacid 0.97 0.0236 no no no no dn no d18:1-18:1-SM+blood UFA%+blood 0.461654135 0 0 serum_phospholipids serum_fattyacid 0.916 0.0236 no no no no dn no d18:1-20:1-SM+blood UFA%+blood 0.512781955 0 0 serum_phospholipids serum_fattyacid 0.0992 0.0236 no no no no dn no DCA+stool UFA%+blood 0 0 -0.569924812 stool_bileacids serum_fattyacid 0.195 0.0236 no no no no dn no decanoic acid C10+blood UFA%+blood 0 0 0.506324786 serum_mcfa serum_fattyacid 6.64E-11 0.0236 dn dn no no dn no Diabetic cardiomyopathy UFA%+blood 0 -0.573529412 0 kegg serum_fattyacid NA 0.0236 no no no no dn no DMG+blood UFA%+blood 0 0 0.522051282 serum_choline serum_fattyacid 0.909 0.0236 no no no no dn no Dopaminergic synapse UFA%+blood 0 -0.564705882 0 kegg serum_fattyacid NA 0.0236 no up no no dn no DPA+blood UFA%+blood 0 0.522058824 0 serum_ARA serum_fattyacid 0.519 0.0236 no no no no dn no EGFR tyrosine kinase inhibitor resistance UFA%+blood 0 -0.723529412 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Endocrine resistance UFA%+blood 0 0 -0.554615385 kegg serum_fattyacid NA 0.0236 no no no no dn no Endocytosis UFA%+blood 0 0.702941176 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Epithelial cell signaling in Helicobacter pylori infection UFA%+blood 0.459649123 0.644117647 0 kegg serum_fattyacid NA 0.0236 no no no no dn no ErbB signaling pathway UFA%+blood 0 0 -0.432307692 kegg serum_fattyacid NA 0.0236 no no no no dn no Ethanolamine+blood UFA%+blood 0 0.602941176 0 serum_aminoacids serum_fattyacid 0.122 0.0236 up no no no dn no Fc epsilon RI signaling pathway UFA%+blood 0 0.558823529 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Fc gamma R-mediated phagocytosis UFA%+blood 0 0.7 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Fusobacterium UFA%+blood 0 0 0.468093501 Genus serum_fattyacid 0.628 0.0236 no no no no dn no Gastric cancer UFA%+blood 0 0 -0.44 kegg serum_fattyacid NA 0.0236 no no no no dn no GCDCA+blood UFA%+blood -0.535338346 0 0 serum_bileacids serum_fattyacid 0.31 0.0236 no no no no dn no Glucagon signaling pathway UFA%+blood 0 -0.652941176 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Glycine+blood UFA%+blood 0.536842105 0.681372549 0.567179487 serum_aminoacids serum_fattyacid 0.00408 0.0236 dn no up no dn no Graft-versus-host disease UFA%+blood 0 0.588235294 0 kegg serum_fattyacid NA 0.0236 no no no no dn no "Growth hormone synthesis, secretion and action" UFA%+blood 0 0 -0.565384615 kegg serum_fattyacid NA 0.0236 no no no no dn no GUDCA+blood UFA%+blood -0.496240602 0 0 serum_bileacids serum_fattyacid 0.0766 0.0236 no no dn no dn no HCA+blood UFA%+blood 0 -0.49980696 0 serum_bileacids serum_fattyacid 0.544 0.0236 no no no no dn no HDCA+blood UFA%+blood 0.518101712 0 0 serum_bileacids serum_fattyacid 0.483 0.0236 no no no no dn no Hepatitis B UFA%+blood 0 0.5 0 kegg serum_fattyacid NA 0.0236 no no no no dn no HIF-1 signaling pathway UFA%+blood 0 -0.591176471 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Human papillomavirus infection UFA%+blood 0 0.611764706 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Huntington disease UFA%+blood 0 -0.570588235 0 kegg serum_fattyacid NA 0.0236 no no no no dn no IL-17 signaling pathway UFA%+blood 0 0.641176471 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Inflammatory mediator regulation of TRP channels UFA%+blood 0 -0.594117647 -0.481538462 kegg serum_fattyacid NA 0.0236 no no no no dn no Influenza A UFA%+blood 0.610526316 0 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Insulin secretion UFA%+blood 0 0 -0.404615385 yes kegg serum_fattyacid NA 0.0236 no up up no dn no Insulin signaling pathway UFA%+blood 0 -0.694117647 0 kegg serum_fattyacid NA 0.0236 no no no no dn no iso-DCA+blood UFA%+blood 0.621052632 0 0 serum_bileacids serum_fattyacid 0.38 0.0236 no no no no dn no L-Arginine+blood UFA%+blood 0 0 0.543931624 serum_aminoacids serum_fattyacid 0.316 0.0236 no no no no dn no L-Asparagine+blood UFA%+blood 0 0.578431373 0.667692308 serum_aminoacids serum_fattyacid 0.784 0.0236 no no no no dn no L-Glutamic acid+blood UFA%+blood 0 0.504901961 0 yes serum_aminoacids serum_fattyacid 6.20E-05 0.0236 up up no no dn no L-Glutamine+blood UFA%+blood 0.455639098 0 0.831111111 serum_aminoacids serum_fattyacid 0.639 0.0236 no no no no dn no L-Histidine+blood UFA%+blood 0.535338346 0 0.548717949 serum_aminoacids serum_fattyacid 0.109 0.0236 no no no no dn no L-Isoleucine+blood UFA%+blood 0 0 0.414017094 yes serum_aminoacids serum_fattyacid 5.47E-06 0.0236 up up no no dn no L-Leucine+blood UFA%+blood 0 0 0.47008547 yes serum_aminoacids serum_fattyacid 3.22E-05 0.0236 up up no no dn no L-Lysine+blood UFA%+blood 0.458646617 0.573529412 0.422905983 yes serum_aminoacids serum_fattyacid 0.0107 0.0236 no up no no dn no L-Methionine+blood UFA%+blood 0 0.551470588 0 serum_aminoacids serum_fattyacid 0.626 0.0236 no no no no dn no L-Phenylalanine+blood UFA%+blood 0 0.549019608 0 yes serum_aminoacids serum_fattyacid 0.0103 0.0236 up up no no dn no L-Tryptophan+blood UFA%+blood 0 0 0.486495726 serum_aminoacids serum_fattyacid 0.164 0.0236 no no no no dn no lauric acid C12+blood UFA%+blood 0.514285714 0 0 serum_mcfa serum_fattyacid 0.015 0.0236 no dn dn no dn no Legionellosis UFA%+blood -0.461403509 0 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Lipid and atherosclerosis UFA%+blood 0 0.855882353 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Long-term depression UFA%+blood 0 0 -0.424615385 kegg serum_fattyacid NA 0.0236 no no no no dn no Long-term potentiation UFA%+blood 0 -0.520588235 0 kegg serum_fattyacid NA 0.0236 no no up no dn no Longevity regulating pathway - multiple species UFA%+blood -0.457894737 0 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Lysosome UFA%+blood 0 0.564705882 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Melanogenesis UFA%+blood 0 0 -0.401538462 kegg serum_fattyacid NA 0.0236 no no no no dn no MicroRNAs in cancer UFA%+blood 0 0 -0.428461538 kegg serum_fattyacid NA 0.0236 no no no no dn no mRNA surveillance pathway UFA%+blood 0 -0.75 0 kegg serum_fattyacid NA 0.0236 no no no no dn no mTOR signaling pathway UFA%+blood 0 -0.717647059 0 kegg serum_fattyacid NA 0.0236 no no no no dn no MUFA%+blood UFA%+blood 0.854135338 0.882352941 0.767521368 serum_fattyacid serum_fattyacid 0.00142 0.0236 up no dn no dn no Natural killer cell mediated cytotoxicity UFA%+blood 0 0.644117647 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Neuroactive ligand-receptor interaction UFA%+blood 0 0.7 0 kegg serum_fattyacid NA 0.0236 up up up no dn no Neutrophil extracellular trap formation UFA%+blood 0 0.664705882 0 kegg serum_fattyacid NA 0.0236 no no no no dn no NF-kappa B signaling pathway UFA%+blood 0 0.544117647 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Nicotinate and nicotinamide metabolism UFA%+blood 0 0.635294118 0 kegg serum_fattyacid NA 0.0236 no no no no dn no NOD-like receptor signaling pathway UFA%+blood 0 0.697058824 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Non-alcoholic fatty liver disease UFA%+blood 0 0 -0.424615385 kegg serum_fattyacid NA 0.0236 no no no no dn no octanoic acid C8+blood UFA%+blood 0 0 0.636923077 serum_mcfa serum_fattyacid 2.84E-11 0.0236 dn dn dn no dn no Olfactory transduction UFA%+blood 0 0.638235294 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Osteoclast differentiation UFA%+blood 0 0.652941176 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Oxidative phosphorylation UFA%+blood 0 -0.544117647 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Pancreatic cancer UFA%+blood 0 0 -0.458461538 kegg serum_fattyacid NA 0.0236 no no no no dn no "Parathyroid hormone synthesis, secretion and action" UFA%+blood 0 -0.555882353 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Pathogenic Escherichia coli infection UFA%+blood 0 0.555882353 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Peroxisome UFA%+blood 0 0.641176471 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Pertussis UFA%+blood 0 0.773529412 0 kegg serum_fattyacid NA 0.0236 no no dn no dn no Phagosome UFA%+blood 0 0.594117647 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Phospholipase D signaling pathway UFA%+blood 0 0 -0.434615385 kegg serum_fattyacid NA 0.0236 no up up no dn no Prevotella UFA%+blood -0.644118401 0 0 acetate-producing Genus serum_fattyacid 0.287 0.0236 no no no no dn no Prion disease UFA%+blood 0 -0.632352941 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Propionic acid+stool UFA%+blood 0 0 -0.509774436 yes stool_scfa serum_fattyacid 0.0436 0.0236 dn no up no dn no Proteasome UFA%+blood 0 0 0.520769231 kegg serum_fattyacid NA 0.0236 no no no no dn no Protein processing in endoplasmic reticulum UFA%+blood 0 -0.726470588 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Proteoglycans in cancer UFA%+blood 0 -0.685294118 0 kegg serum_fattyacid NA 0.0236 no no no no dn no PUFA/MUFA+blood UFA%+blood 0.49924812 0.580882353 0.412649573 serum_fattyacid serum_fattyacid 0.00108 0.0236 dn no up no dn no PUFA/UFA+blood UFA%+blood 0.869172932 0.899509804 0.837264957 serum_fattyacid serum_fattyacid 0.000732 0.0236 dn no up no dn no PUFA%+blood UFA%+blood 0.921804511 0.914215686 0.909059829 serum_fattyacid serum_fattyacid 0.0013 0.0236 dn no up no dn no Ras signaling pathway UFA%+blood 0 -0.608823529 0 yes kegg serum_fattyacid NA 0.0236 no up up no dn no Retrograde endocannabinoid signaling UFA%+blood 0 -0.614705882 0 kegg serum_fattyacid NA 0.0236 no no up no dn no Rheumatoid arthritis UFA%+blood 0 0.641176471 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Ribosome UFA%+blood 0 -0.658823529 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Ribosome biogenesis in eukaryotes UFA%+blood 0 -0.585294118 0 kegg serum_fattyacid NA 0.0236 no no no no dn no RIG-I-like receptor signaling pathway UFA%+blood 0 0.535294118 0 kegg serum_fattyacid NA 0.0236 no no no no dn no RNA degradation UFA%+blood 0 -0.7 0 kegg serum_fattyacid NA 0.0236 no no no no dn no RNA transport UFA%+blood 0 -0.688235294 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Ruminococcus UFA%+blood 0 0 -0.436098819 Genus serum_fattyacid 0.0679 0.0236 no no dn no dn no Salmonella infection UFA%+blood 0 0.505882353 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Serine+blood UFA%+blood 0.703759398 0.556372549 0.66974359 serum_aminoacids serum_fattyacid 0.942 0.0236 no no no no dn no SFA%+blood UFA%+blood 0.861654135 0.948529412 0.796239316 serum_fattyacid serum_fattyacid 0.0236 0.0236 no up no no dn no Signaling pathways regulating pluripotency of stem cells UFA%+blood 0 0 -0.443846154 kegg serum_fattyacid NA 0.0236 no no no no dn no Spinocerebellar ataxia UFA%+blood 0 -0.635294118 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Staphylococcus aureus infection UFA%+blood 0 0.623529412 0 kegg serum_fattyacid NA 0.0236 up no no no dn no Systemic lupus erythematosus UFA%+blood 0 0.641176471 0 kegg serum_fattyacid NA 0.0236 no no no no dn no T-a-MCA+blood UFA%+blood 0 0 0.425650077 serum_bileacids serum_fattyacid 0.478 0.0236 no no no no dn no Taurine+blood UFA%+blood 0 0.509803922 0 serum_aminoacids serum_fattyacid 0.857 0.0236 no no no no dn no TCA+stool UFA%+blood -0.580468225 0 0 stool_bileacids serum_fattyacid 0.458 0.0236 no no no no dn no Th1 and Th2 cell differentiation UFA%+blood 0.456140351 0 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Thermogenesis UFA%+blood 0 -0.632352941 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Toll-like receptor signaling pathway UFA%+blood 0 0.602941176 0 yes kegg serum_fattyacid NA 0.0236 no no no no dn no total_stool_scfa+stool UFA%+blood 0 0 -0.455639098 stool_scfa serum_fattyacid 0.0534 0.0236 dn no up no dn no Toxoplasmosis UFA%+blood 0 0.508823529 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Transcriptional misregulation in cancer UFA%+blood 0 0.514705882 -0.486923077 kegg serum_fattyacid NA 0.0236 no no no no dn no Tuberculosis UFA%+blood 0 0.670588235 0 kegg serum_fattyacid NA 0.0236 no no dn no dn no Type I diabetes mellitus UFA%+blood 0 0.588235294 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Viral carcinogenesis UFA%+blood 0 0.614705882 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Viral myocarditis UFA%+blood 0 0.508823529 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Wnt signaling pathway UFA%+blood 0 -0.755882353 0 kegg serum_fattyacid NA 0.0236 no no no no dn no Yersinia infection UFA%+blood 0 0.602941176 0 kegg serum_fattyacid NA 0.0236 no no no no dn no 12-ketoDCA+blood UFA+blood -0.513021871 0 0 serum_bileacids serum_fattyacid 0.517 0.0444 no no no up no dn 14:0/16:0-PC+blood UFA+blood 0 0 0.401025641 serum_phospholipids serum_fattyacid 0.0358 0.0444 no up no up no dn 14:0+blood UFA+blood 0.571428571 0 0.553504274 yes serum_fattyacid serum_fattyacid 0.00572 0.0444 up no dn up no dn 16:0/18:1-PC+blood UFA+blood 0 0 0.468717949 serum_phospholipids serum_fattyacid 6.15E-07 0.0444 up up up up no dn 16:0/20:5-PG+blood UFA+blood 0 0 -0.425641026 serum_phospholipids serum_fattyacid 0.00656 0.0444 no up no up no dn 16:0+blood UFA+blood 0.855639098 0.875 0.767521368 yes serum_fattyacid serum_fattyacid 0.00876 0.0444 up no no up no dn 16:1/18:2-PG+blood UFA+blood 0 0 -0.452307692 serum_phospholipids serum_fattyacid 1.40E-08 0.0444 no up up up no dn 16:1+blood UFA+blood 0.801503759 0 0.410598291 yes serum_fattyacid serum_fattyacid 0.0186 0.0444 no no dn up no dn 18:0/16:0-PC+blood UFA+blood 0 0 0.415384615 serum_phospholipids serum_fattyacid 9.64E-07 0.0444 up up up up no dn 18:0/20:4-PI+blood UFA+blood 0 0.575980392 0 serum_phospholipids serum_fattyacid 0.167 0.0444 no no no up no dn 18:0+blood UFA+blood 0.739849624 0.661764706 0.627350427 serum_fattyacid serum_fattyacid 0.344 0.0444 no no no up no dn 18:1/18:0-PS+blood UFA+blood 0 0.642156863 0 serum_phospholipids serum_fattyacid 0.193 0.0444 no no no up no dn 18:1/18:1-PG+blood UFA+blood 0 0 -0.44 serum_phospholipids serum_fattyacid 0.00352 0.0444 no up up up no dn 18:1/18:2-PG+blood UFA+blood 0 0 -0.450940171 serum_phospholipids serum_fattyacid 5.58E-07 0.0444 no up up up no dn 18:1+blood UFA+blood 0.891729323 0.710784314 0.634871795 yes serum_fattyacid serum_fattyacid 0.00202 0.0444 up no dn up no dn 18:2n6c+blood UFA+blood 0.663157895 0.740196078 0.791452991 serum_fattyacid serum_fattyacid 0.15 0.0444 no no no up no dn 18:3n3+blood UFA+blood 0.648120301 0 0 serum_fattyacid serum_fattyacid 0.291 0.0444 no no no up no dn 20:2/18:3-PE+blood UFA+blood 0 0.605392157 0 serum_phospholipids serum_fattyacid 0.0391 0.0444 up up no up no dn 20:3/16:0-PC+blood UFA+blood 0 0.509803922 0 serum_phospholipids serum_fattyacid 0.00405 0.0444 no up up up no dn 20:3/18:0-PC+blood UFA+blood 0.446616541 0 0 serum_phospholipids serum_fattyacid 0.296 0.0444 no no no up no dn 20:3/18:0-PI+blood UFA+blood 0 0.507352941 0 serum_phospholipids serum_fattyacid 0.289 0.0444 no no no up no dn 20:3n6+blood UFA+blood 0 0 0.441367521 serum_fattyacid serum_fattyacid 0.0884 0.0444 up no no up no dn 20:4-LPE+blood UFA+blood 0 0.578431373 0 serum_phospholipids serum_fattyacid 0.552 0.0444 no no no up no dn 20:4/18:0-PE+blood UFA+blood 0 0.50245098 0 serum_phospholipids serum_fattyacid 0.000755 0.0444 up up no up no dn 20:4n6+blood UFA+blood 0 0.588235294 0 serum_fattyacid serum_fattyacid 0.133 0.0444 no no no up no dn 22:6n3+blood UFA+blood 0.458646617 0 0 serum_fattyacid serum_fattyacid 0.792 0.0444 no no no up no dn 24:0+blood UFA+blood 0 0.50245098 0 serum_fattyacid serum_fattyacid 0.034 0.0444 dn no up up no dn 24:1+blood UFA+blood 0 0.62745098 0 serum_fattyacid serum_fattyacid 0.00582 0.0444 no dn dn up no dn 3-(3-Hydroxyphenyl)propanoic acid+stool UFA+blood 0.642857143 0 0 stool_cometabolism serum_fattyacid 0.33 0.0444 no no no up no dn AA+blood UFA+blood 0.508270677 0 0 serum_ARA serum_fattyacid 0.212 0.0444 no no no up no dn AGE-RAGE signaling pathway in diabetic complications UFA+blood 0.614035088 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn Alzheimer disease UFA+blood 0 0 -0.428461538 kegg serum_fattyacid NA 0.0444 no no no up no dn Bifidobacterium UFA+blood 0 -0.695279101 0 acetate-producing Genus serum_fattyacid 0.105 0.0444 no dn no up no dn Biosynthesis of cofactors UFA+blood -0.559649123 0 0.48 kegg serum_fattyacid NA 0.0444 no no no up no dn Cardiac muscle contraction UFA+blood 0 0 -0.46 kegg serum_fattyacid NA 0.0444 no no up up no dn cGMP-PKG signaling pathway UFA+blood 0.466666667 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn Cholinergic synapse UFA+blood 0.456140351 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn Cytokine-cytokine receptor interaction UFA+blood 0.489473684 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn Focal adhesion UFA+blood 0 0 -0.409230769 kegg serum_fattyacid NA 0.0444 no up up up no dn GABAergic synapse UFA+blood 0.515789474 0 0 kegg serum_fattyacid NA 0.0444 no up up up no dn GCDCA+blood UFA+blood 0 0 -0.426324786 serum_bileacids serum_fattyacid 0.31 0.0444 no no no up no dn GLCA+blood UFA+blood 0 -0.560112034 -0.471233443 serum_bileacids serum_fattyacid 0.319 0.0444 no no no up no dn Glioma UFA+blood 0.533333333 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn Glutathione metabolism UFA+blood 0 0 0.416923077 kegg serum_fattyacid NA 0.0444 no no no up no dn "Glycine, serine and threonine metabolism" UFA+blood -0.456140351 -0.652941176 0.442307692 kegg serum_fattyacid NA 0.0444 no up no up no dn HCA+blood UFA+blood 0 0 -0.425436597 serum_bileacids serum_fattyacid 0.544 0.0444 no no no up no dn iso-DCA+blood UFA+blood 0 0 0.463247863 serum_bileacids serum_fattyacid 0.38 0.0444 no no no up no dn iso-LCA+blood UFA+blood -0.4804104 0 0 serum_bileacids serum_fattyacid 0.507 0.0444 no no no up no dn isovaleric acid iso-C5+blood UFA+blood 0 0.526960784 0 serum_scfa serum_fattyacid 0.117 0.0444 no no no up no dn L-Leucine+blood UFA+blood -0.467669173 0 0 yes serum_aminoacids serum_fattyacid 3.22E-05 0.0444 up up no up no dn L-Proline+blood UFA+blood -0.509774436 0 -0.464615385 yes serum_aminoacids serum_fattyacid 0.00265 0.0444 up up no up no dn LCA+blood UFA+blood -0.469163334 0 0 serum_bileacids serum_fattyacid 0.884 0.0444 no no no up no dn Lipid and atherosclerosis UFA+blood 0.654385965 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn Mitophagy - animal UFA+blood -0.51754386 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn MUFA+blood UFA+blood 0.89924812 0.720588235 0.627350427 serum_fattyacid serum_fattyacid 0.00175 0.0444 up no dn up no dn n6+blood UFA+blood 0.855639098 0.911764706 0.943931624 serum_fattyacid serum_fattyacid 0.153 0.0444 no no no up no dn NOD-like receptor signaling pathway UFA+blood 0.587719298 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn Parkinson disease UFA+blood -0.487719298 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn Pathways of neurodegeneration - multiple diseases UFA+blood -0.496491228 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn Peroxisome UFA+blood 0.485964912 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn Pertussis UFA+blood 0.650877193 0 0 kegg serum_fattyacid NA 0.0444 no no dn up no dn Porphyrin and chlorophyll metabolism UFA+blood -0.5 -0.658823529 0.482307692 kegg serum_fattyacid NA 0.0444 no no no up no dn Proteoglycans in cancer UFA+blood -0.515789474 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn PUFA/MUFA+blood UFA+blood -0.478195489 0 0 serum_fattyacid serum_fattyacid 0.00108 0.0444 dn no up up no dn PUFA+blood UFA+blood 0.933834586 0.950980392 0.932307692 serum_fattyacid serum_fattyacid 0.212 0.0444 no no no up no dn Purine metabolism UFA+blood 0 -0.517647059 0 kegg serum_fattyacid NA 0.0444 no no no up no dn Ruminococcus UFA+blood 0 -0.526960784 0 acetate-producing Genus serum_fattyacid 0.335 0.0444 no no no up no dn Salivary secretion UFA+blood 0 0.511764706 0 kegg serum_fattyacid NA 0.0444 no no no up no dn SFA+blood UFA+blood 0.855639098 0.899509804 0.834529915 serum_fattyacid serum_fattyacid 0.0386 0.0444 up no no up no dn Shigellosis UFA+blood -0.622807018 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn Sphingolipid signaling pathway UFA+blood 0.456140351 0 -0.499230769 kegg serum_fattyacid NA 0.0444 no no no up no dn T-a-MCA+blood UFA+blood 0 0 0.516816809 serum_bileacids serum_fattyacid 0.478 0.0444 no no no up no dn ToFA+blood UFA+blood 0.966917293 0.985294118 0.952820513 serum_fattyacid serum_fattyacid 0.0307 0.0444 up no dn up no dn Tuberculosis UFA+blood 0.505263158 0 0 kegg serum_fattyacid NA 0.0444 no no dn up no dn Ubiquitin mediated proteolysis UFA+blood -0.556140351 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn VEGF signaling pathway UFA+blood 0.489473684 0 0 kegg serum_fattyacid NA 0.0444 no no no up no dn 12-HEPE+blood undecanoid acid C11+blood 0.505555573 0 0 serum_ARA serum_mcfa 0.312 1.35E-10 no no no dn dn no 14:0/18:0-PC+blood undecanoid acid C11+blood 0 0.512254902 0 serum_phospholipids serum_mcfa 0.00289 1.35E-10 up up no dn dn no 14:0/18:2-PC+blood undecanoid acid C11+blood 0 0.558823529 0 serum_phospholipids serum_mcfa 0.102 1.35E-10 no up no dn dn no 14:1/18:2-PG+blood undecanoid acid C11+blood 0 0.495098039 0 serum_phospholipids serum_mcfa 0.00259 1.35E-10 no up up dn dn no 16:0/16:0-PC+blood undecanoid acid C11+blood 0 0 -0.461196581 serum_phospholipids serum_mcfa 0.00079 1.35E-10 no up up dn dn no 16:0/16:1-PC+blood undecanoid acid C11+blood 0 0.482843137 0 serum_phospholipids serum_mcfa 0.00283 1.35E-10 up up no dn dn no 16:0/16:1-PI+blood undecanoid acid C11+blood -0.497744361 0 0 serum_phospholipids serum_mcfa 0.262 1.35E-10 no no no dn dn no 16:0/18:3-PC+blood undecanoid acid C11+blood -0.497744361 0 0 serum_phospholipids serum_mcfa 0.00216 1.35E-10 no up up dn dn no 16:0/22:0-PE+blood undecanoid acid C11+blood 0 -0.514705882 0 serum_phospholipids serum_mcfa 0.00839 1.35E-10 dn no up dn dn no 18:0-LPC+blood undecanoid acid C11+blood 0 0.539215686 0 serum_phospholipids serum_mcfa 0.554 1.35E-10 no no no dn dn no 18:0-LPE+blood undecanoid acid C11+blood 0 0.634803922 0 serum_phospholipids serum_mcfa 0.491 1.35E-10 no no no dn dn no 18:0/18:2-PC+blood undecanoid acid C11+blood 0.455639098 0 0 serum_phospholipids serum_mcfa 1.74E-06 1.35E-10 no up up dn dn no 18:0/18:2-PI+blood undecanoid acid C11+blood 0 0.504901961 0 serum_phospholipids serum_mcfa 0.179 1.35E-10 no no no dn dn no 18:0/20:4-PC+blood undecanoid acid C11+blood 0 0 -0.404444444 serum_phospholipids serum_mcfa 0.454 1.35E-10 no no no dn dn no 18:0+blood undecanoid acid C11+blood 0 0 -0.40991453 serum_fattyacid serum_mcfa 0.344 1.35E-10 no no no dn dn no 18:1-LPC+blood undecanoid acid C11+blood 0.506766917 0 0 serum_phospholipids serum_mcfa 0.179 1.35E-10 no no no dn dn no 18:1/18:0-PC+blood undecanoid acid C11+blood 0.44962406 0 0 serum_phospholipids serum_mcfa 1.83E-06 1.35E-10 no up up dn dn no 18:1/18:1-PC+blood undecanoid acid C11+blood 0 0.482843137 0 serum_phospholipids serum_mcfa 1.34E-05 1.35E-10 no up up dn dn no 18:1/18:1-PI+blood undecanoid acid C11+blood 0.557894737 0 0 serum_phospholipids serum_mcfa 0.111 1.35E-10 dn no no dn dn no 18:1/20:3-PC+blood undecanoid acid C11+blood 0 0 -0.403760684 serum_phospholipids serum_mcfa 0.00872 1.35E-10 no up up dn dn no 18:1/20:4-PI+blood undecanoid acid C11+blood 0 0 -0.528888889 serum_phospholipids serum_mcfa 0.192 1.35E-10 no no no dn dn no 18:2-LPC+blood undecanoid acid C11+blood 0.568421053 0 0 serum_phospholipids serum_mcfa 0.00743 1.35E-10 dn no up dn dn no 18:2-LPE+blood undecanoid acid C11+blood 0 0.620098039 0 serum_phospholipids serum_mcfa 0.112 1.35E-10 no no no dn dn no 18:2/16:0-PC+blood undecanoid acid C11+blood 0.454135338 0 0 serum_phospholipids serum_mcfa 8.67E-05 1.35E-10 no up up dn dn no 18:2/18:1-PC+blood undecanoid acid C11+blood 0.476691729 0 0 serum_phospholipids serum_mcfa 2.30E-05 1.35E-10 dn up up dn dn no 18:3/16:0-PE+blood undecanoid acid C11+blood -0.679699248 0 0 serum_phospholipids serum_mcfa 0.00149 1.35E-10 up up no dn dn no 18:3n6+blood undecanoid acid C11+blood 0 0 -0.52957265 serum_fattyacid serum_mcfa 0.0463 1.35E-10 up no dn dn dn no 2-methyl-butyric acid m-C4+blood undecanoid acid C11+blood 0.616541353 0 0 serum_scfa serum_mcfa 0.262 1.35E-10 no no no dn dn no 20:2-LPC+blood undecanoid acid C11+blood 0 0 -0.408547009 serum_phospholipids serum_mcfa 0.119 1.35E-10 no no up dn dn no 20:2+blood undecanoid acid C11+blood 0 0.512254902 0 serum_fattyacid serum_mcfa 0.478 1.35E-10 no no no dn dn no 20:3-LPE+blood undecanoid acid C11+blood 0 0.639705882 0 serum_phospholipids serum_mcfa 0.084 1.35E-10 no up no dn dn no 20:3n6+blood undecanoid acid C11+blood 0 0.56127451 0 serum_fattyacid serum_mcfa 0.0884 1.35E-10 up no no dn dn no 20:5-LPC+blood undecanoid acid C11+blood 0 -0.671568627 0 serum_phospholipids serum_mcfa 0.558 1.35E-10 no no no dn dn no 22:2-LPA+blood undecanoid acid C11+blood 0 0.492647059 0 serum_phospholipids serum_mcfa 0.0443 1.35E-10 dn no no dn dn no 22:6-LPC+blood undecanoid acid C11+blood 0 -0.50245098 0 serum_phospholipids serum_mcfa 0.127 1.35E-10 no no up dn dn no 24:1+blood undecanoid acid C11+blood 0 -0.524509804 0 serum_fattyacid serum_mcfa 0.00582 1.35E-10 no dn dn dn dn no Creatinine+blood undecanoid acid C11+blood 0.538345865 0 0 serum_choline serum_mcfa 0.437 1.35E-10 no no no dn dn no Cysteine+blood undecanoid acid C11+blood 0.506766917 0 0 yes serum_aminoacids serum_mcfa 1.81E-07 1.35E-10 dn up up dn dn no decanoic acid C10+blood undecanoid acid C11+blood 0.942857143 0.754901961 0.551452991 serum_mcfa serum_mcfa 6.64E-11 1.35E-10 dn dn no dn dn no DHA+blood undecanoid acid C11+blood 0 0 0.418119658 serum_ARA serum_mcfa 0.872 1.35E-10 no no no dn dn no EPA+blood undecanoid acid C11+blood 0 -0.495098039 0 serum_ARA serum_mcfa 0.212 1.35E-10 no no no dn dn no HDCA+blood undecanoid acid C11+blood 0 0 0.437711631 serum_bileacids serum_mcfa 0.483 1.35E-10 no no no dn dn no heptanoic acid C7+blood undecanoid acid C11+blood 0.630075188 0.632352941 0 serum_mcfa serum_mcfa 8.27E-11 1.35E-10 dn dn no dn dn no isobutyric acid C4+blood undecanoid acid C11+blood 0.518796992 0 0 serum_scfa serum_mcfa 0.0151 1.35E-10 up up no dn dn no L-Alanine+blood undecanoid acid C11+blood 0 0 -0.424273504 yes serum_aminoacids serum_mcfa 0.00138 1.35E-10 up up no dn dn no L-Methionine+blood undecanoid acid C11+blood 0.452631579 0 0 serum_aminoacids serum_mcfa 0.626 1.35E-10 no no no dn dn no lauric acid C12+blood undecanoid acid C11+blood 0.896240602 0.723039216 0.680683761 serum_mcfa serum_mcfa 0.015 1.35E-10 no dn dn dn dn no LCA+blood undecanoid acid C11+blood 0 0.499012052 0 serum_bileacids serum_mcfa 0.884 1.35E-10 no no no dn dn no nonanoic acid C9+blood undecanoid acid C11+blood 0.771428571 0.789215686 0.79008547 serum_mcfa serum_mcfa 6.51E-11 1.35E-10 dn dn no dn dn no octanoic acid C8+blood undecanoid acid C11+blood 0.672180451 0.529411765 0 serum_mcfa serum_mcfa 2.84E-11 1.35E-10 dn dn dn dn dn no TMAO+blood undecanoid acid C11+blood 0.503759398 0 0 serum_choline serum_mcfa 0.00706 1.35E-10 up up no dn dn no total_blood_mcfa+blood undecanoid acid C11+blood 0.923308271 0.740196078 0.742222222 serum_mcfa serum_mcfa 8.76E-11 1.35E-10 dn dn dn dn dn no 12-HEPE+blood valeric acid C5+blood 0 0.484097716 0 serum_ARA serum_scfa 0.312 0.00202 no no no dn dn no 12-ketoDCA+blood valeric acid C5+blood 0 0.517029533 0 serum_bileacids serum_scfa 0.517 0.00202 no no no dn dn no 16:1/16:1-PC+blood valeric acid C5+blood 0 -0.625 0 serum_phospholipids serum_scfa 0.0177 0.00202 no no up dn dn no 18:0+blood valeric acid C5+blood 0.466165414 0 0 serum_fattyacid serum_scfa 0.344 0.00202 no no no dn dn no 18:1-LPC+blood valeric acid C5+blood 0 0.524509804 0 serum_phospholipids serum_scfa 0.179 0.00202 no no no dn dn no 18:1/18:2-PI+blood valeric acid C5+blood -0.544360902 0 0 serum_phospholipids serum_scfa 0.0164 0.00202 dn no up dn dn no 2-methyl-butyric acid m-C4+blood valeric acid C5+blood 0.646616541 0.794117647 0.777094017 serum_scfa serum_scfa 0.262 0.00202 no no no dn dn no 20:0-LPC+blood valeric acid C5+blood 0 0.529411765 -0.416752137 serum_phospholipids serum_scfa 0.199 0.00202 no no no dn dn no 22:0/16:0-PE+blood valeric acid C5+blood 0 0 -0.403760684 serum_phospholipids serum_scfa 0.091 0.00202 no no up dn dn no 22:2-LPA+blood valeric acid C5+blood -0.445112782 0 0 serum_phospholipids serum_scfa 0.0443 0.00202 dn no no dn dn no 9-HODE+blood valeric acid C5+blood -0.554887218 0 0 serum_ARA serum_scfa 0.297 0.00202 no no no dn dn no acetic acid C2+blood valeric acid C5+blood 0.557894737 0 0 serum_scfa serum_scfa 0.000193 0.00202 up dn no dn dn no butyric acid C4+blood valeric acid C5+blood 0.759398496 0.56372549 0.726495726 serum_scfa serum_scfa 0.407 0.00202 no no no dn dn no Cystine+blood valeric acid C5+blood 0.566917293 0 0 yes serum_aminoacids serum_scfa 0.00028 0.00202 up up no dn dn no decanoic acid C10+blood valeric acid C5+blood 0.553383459 0 0 serum_mcfa serum_scfa 6.64E-11 0.00202 dn dn no dn dn no heptanoic acid C7+blood valeric acid C5+blood 0.792481203 0 0.502222222 serum_mcfa serum_scfa 8.27E-11 0.00202 dn dn no dn dn no iso-heptanoic acid C7+blood valeric acid C5+blood 0.467669173 0 0 serum_mcfa serum_scfa 0.00256 0.00202 up up no dn dn no iso-LCA+blood valeric acid C5+blood 0 0.780064817 0 serum_bileacids serum_scfa 0.507 0.00202 no no no dn dn no isobutyric acid C4+blood valeric acid C5+blood 0.763909774 0.661764706 0.859145299 serum_scfa serum_scfa 0.0151 0.00202 up up no dn dn no L-Asparagine+blood valeric acid C5+blood 0.523308271 0 0 serum_aminoacids serum_scfa 0.784 0.00202 no no no dn dn no L-Lysine+blood valeric acid C5+blood 0.45112782 0 0 yes serum_aminoacids serum_scfa 0.0107 0.00202 no up no dn dn no lauric acid C12+blood valeric acid C5+blood 0.45112782 0 0 serum_mcfa serum_scfa 0.015 0.00202 no dn dn dn dn no LCA+blood valeric acid C5+blood 0 0.487540511 0 serum_bileacids serum_scfa 0.884 0.00202 no no no dn dn no nonanoic acid C9+blood valeric acid C5+blood 0.720300752 0 0 serum_mcfa serum_scfa 6.51E-11 0.00202 dn dn no dn dn no octanoic acid C8+blood valeric acid C5+blood 0.759398496 0 0 serum_mcfa serum_scfa 2.84E-11 0.00202 dn dn dn dn dn no propionic acid C3+blood valeric acid C5+blood 0.905263158 0.654411765 0.856410256 serum_scfa serum_scfa 0.104 0.00202 no dn no dn dn no Serine+blood valeric acid C5+blood 0.446616541 0 0 serum_aminoacids serum_scfa 0.942 0.00202 no no no dn dn no total_blood_mcfa+blood valeric acid C5+blood 0.712781955 0 0 serum_mcfa serum_scfa 8.76E-11 0.00202 dn dn dn dn dn no undecanoid acid C11+blood valeric acid C5+blood 0.527819549 0 0 serum_mcfa serum_scfa 1.35E-10 0.00202 dn dn no dn dn no CA+stool Valeric acid+stool -0.82868937 -0.853146853 0 stool_bileacids stool_scfa 0.827 0.382 no no no no no no Caproic acid+stool Valeric acid+stool 0 0.58041958 0.612648221 stool_scfa stool_scfa 0.882 0.382 no no no no no no CDCA+stool Valeric acid+stool -0.746130031 -0.902097902 -0.421936759 stool_bileacids stool_scfa 0.663 0.382 no no no no no no DCA+stool Valeric acid+stool 0 0 0.609683794 stool_bileacids stool_scfa 0.195 0.382 no no no no no no GCA+stool Valeric acid+stool -0.517027864 -0.944055944 -0.468379447 stool_bileacids stool_scfa 0.0809 0.382 no no no no no no GCDCA+stool Valeric acid+stool 0 -0.727272727 -0.477272727 yes stool_bileacids stool_scfa 0.0471 0.382 no dn no no no no GDCA+stool Valeric acid+stool -0.481156492 -0.826621233 -0.552918174 stool_bileacids stool_scfa 0.656 0.382 no no no no no no GLCA+stool Valeric acid+stool -0.521370374 0 0 stool_bileacids stool_scfa 0.617 0.382 no no no no no no HCA+stool Valeric acid+stool -0.675954592 0 0 stool_bileacids stool_scfa 0.155 0.382 no no no no no no HDCA+stool Valeric acid+stool 0.593395253 0 0.467391304 stool_bileacids stool_scfa 0.176 0.382 no no no no no no Indole-3-Acetic acid+stool Valeric acid+stool 0 0.727272727 0 stool_cometabolism stool_scfa 0.304 0.382 no no no no no no iso-LCA+stool Valeric acid+stool 0.654620634 0.72027972 0 stool_bileacids stool_scfa 0.72 0.382 no no no no no no Isobutyric acid+stool Valeric acid+stool 0.494324045 0.79020979 0.454545455 stool_scfa stool_scfa 0.408 0.382 no no no no no no Isovaleric acid+stool Valeric acid+stool 0 0.657342657 0.424901186 stool_scfa stool_scfa 0.343 0.382 no no no no no no LCA+stool Valeric acid+stool 0 0.734265734 0.469367589 stool_bileacids stool_scfa 0.314 0.382 no no no no no no nutriCA+stool Valeric acid+stool -0.731682147 0 -0.435770751 stool_bileacids stool_scfa 0.481 0.382 no no no no no no TCA+stool Valeric acid+stool 0 0 -0.559288538 stool_bileacids stool_scfa 0.458 0.382 no no no no no no TDCA+stool Valeric acid+stool 0 0 -0.468993666 stool_bileacids stool_scfa 0.963 0.382 no no no no no no UDCA+stool Valeric acid+stool -0.704850361 -0.902097902 0 stool_bileacids stool_scfa 0.266 0.382 no no no no no no ¦Ø-MCA+stool Valeric acid+stool 0 0 -0.565698782 stool_bileacids stool_scfa 0.919 0.382 no no no no no no "Alanine, aspartate and glutamate metabolism" "Valine, leucine and isoleucine degradation" 0 -0.597826087 0 kegg kegg NA NA no no no no no no Arginine biosynthesis "Valine, leucine and isoleucine degradation" 0 -0.640316206 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism "Valine, leucine and isoleucine degradation" 0.607826087 0.664031621 0.673873874 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) "Valine, leucine and isoleucine degradation" 0.909565217 0.924901186 0.785842986 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism "Valine, leucine and isoleucine degradation" 0.688695652 0.783596838 0.695238095 kegg kegg NA NA no no no no no no Fatty acid biosynthesis "Valine, leucine and isoleucine degradation" 0 -0.566205534 0 kegg kegg NA NA no no no no no no Fatty acid degradation "Valine, leucine and isoleucine degradation" 0.446086957 0 0.56962677 kegg kegg NA NA no no no no no no Fatty acid elongation "Valine, leucine and isoleucine degradation" 0.68 0.615612648 0.811583012 kegg kegg NA NA no no no no no no Fructose and mannose metabolism "Valine, leucine and isoleucine degradation" 0.566956522 0 0 kegg kegg NA NA no no no no no no Galactose metabolism "Valine, leucine and isoleucine degradation" 0.575652174 0 0 kegg kegg NA NA no no no no no no Glycolysis / Gluconeogenesis "Valine, leucine and isoleucine degradation" 0.712173913 0.588932806 0.536164736 kegg kegg NA NA no no no no no no Oxidative phosphorylation "Valine, leucine and isoleucine degradation" -0.431304348 0 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions "Valine, leucine and isoleucine degradation" 0.715652174 0.904150198 0.616216216 kegg kegg NA NA no no no no no no Pentose phosphate pathway "Valine, leucine and isoleucine degradation" 0 -0.45256917 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis "Valine, leucine and isoleucine degradation" 0.907826087 0.654150198 0.586872587 kegg kegg NA NA no no no no no no Pyrimidine metabolism "Valine, leucine and isoleucine degradation" 0.706086957 0.716403162 0 kegg kegg NA NA no no no no no no Steroid biosynthesis "Valine, leucine and isoleucine degradation" 0 0.761857708 0.714285714 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis "Valine, leucine and isoleucine degradation" 0.653043478 0.839920949 0.413127413 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies "Valine, leucine and isoleucine degradation" 0.839130435 0.82312253 0.819047619 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis "Valine, leucine and isoleucine degradation" 0.916521739 0.937747036 0.677477477 kegg kegg NA NA no no no no no no 15-HETE+blood Valine+blood 0 0 -0.542548037 yes serum_ARA serum_aminoacids 0.819 1.22E-06 no no no up up no 16:0/14:0-PC+blood Valine+blood 0.526315789 0 0 yes serum_phospholipids serum_aminoacids 0.0206 1.22E-06 no up up up up no 16:0/18:2-PC+blood Valine+blood 0.526315789 0 0 yes serum_phospholipids serum_aminoacids 3.24E-06 1.22E-06 no up up up up no 16:0/20:4-PE+blood Valine+blood 0 0 -0.417435897 yes serum_phospholipids serum_aminoacids 0.00139 1.22E-06 up up no up up no 16:0/22:6-PC+blood Valine+blood 0.466165414 0 0 yes serum_phospholipids serum_aminoacids 4.53E-05 1.22E-06 no up up up up no 16:0/22:6-PE+blood Valine+blood 0 -0.509803922 0 yes serum_phospholipids serum_aminoacids 0.000934 1.22E-06 up up no up up no 16:1/16:0-PC+blood Valine+blood 0.606015038 0 0 yes serum_phospholipids serum_aminoacids 0.0215 1.22E-06 no up up up up no 18:0-LPE+blood Valine+blood 0 0 -0.473504274 yes serum_phospholipids serum_aminoacids 0.491 1.22E-06 no no no up up no 18:1-LPE+blood Valine+blood -0.506766917 0 0 yes serum_phospholipids serum_aminoacids 0.117 1.22E-06 no no no up up no 18:1/16:0-PC+blood Valine+blood 0.529323308 0 0 yes serum_phospholipids serum_aminoacids 2.43E-05 1.22E-06 no up up up up no 18:1/20:4-PE+blood Valine+blood 0 0 -0.423589744 yes serum_phospholipids serum_aminoacids 0.0578 1.22E-06 up no no up up no 18:3n6+blood Valine+blood -0.530827068 0 0 yes serum_fattyacid serum_aminoacids 0.0463 1.22E-06 up no dn up up no 20:0+blood Valine+blood 0 -0.495098039 0 yes yes serum_fattyacid serum_aminoacids 0.000278 1.22E-06 dn no up up up no 20:1-LPA+blood Valine+blood 0 0.514705882 0 yes serum_phospholipids serum_aminoacids 0.0187 1.22E-06 dn dn no up up no 20:1-LPE+blood Valine+blood 0 -0.512254902 0 yes serum_phospholipids serum_aminoacids 0.465 1.22E-06 no no no up up no 20:2-LPE+blood Valine+blood 0 -0.617647059 0 yes serum_phospholipids serum_aminoacids 0.177 1.22E-06 no no no up up no 20:4-LPE+blood Valine+blood 0 0 -0.414017094 yes serum_phospholipids serum_aminoacids 0.552 1.22E-06 no no no up up no 20:4/16:0-PE+blood Valine+blood -0.448120301 0 0 yes serum_phospholipids serum_aminoacids 0.00529 1.22E-06 no up up up up no 20:4/18:0-PE+blood Valine+blood 0 0 -0.421538462 yes serum_phospholipids serum_aminoacids 0.000755 1.22E-06 up up no up up no 20:5/18:0-PC+blood Valine+blood 0.461654135 0 0 yes serum_phospholipids serum_aminoacids 3.97E-06 1.22E-06 no up up up up no 22:1-LPA+blood Valine+blood 0 0.487745098 0 yes serum_phospholipids serum_aminoacids 0.00373 1.22E-06 no up up up up no 22:6-LPC+blood Valine+blood 0 0 0.417435897 yes serum_phospholipids serum_aminoacids 0.127 1.22E-06 no no up up up no 9-HODE+blood Valine+blood 0 0 -0.401025641 yes serum_ARA serum_aminoacids 0.297 1.22E-06 no no no up up no Axon guidance Valine+blood 0 0 -0.487692308 yes kegg serum_aminoacids NA 1.22E-06 no up up up up no Betaine+blood Valine+blood 0 0 0.431111111 yes serum_choline serum_aminoacids 0.857 1.22E-06 no no no up up no Blautia Valine+blood 0 0.629901961 0 acetate-producing yes Genus serum_aminoacids 1.36E-05 1.22E-06 up dn dn up up no Butyricimonas Valine+blood 0 -0.500315948 0 butyrate-producing yes Genus serum_aminoacids 0.17 1.22E-06 no no no up up no Cell adhesion molecules Valine+blood 0 0 -0.488461538 yes kegg serum_aminoacids NA 1.22E-06 no no no up up no Cellular senescence Valine+blood 0 0 -0.412307692 yes kegg serum_aminoacids NA 1.22E-06 no no no up up no Chemical carcinogenesis - receptor activation Valine+blood 0 -0.529411765 0 yes kegg serum_aminoacids NA 1.22E-06 no no no up up no Choline+blood Valine+blood 0.530827068 0 0.447521368 yes serum_choline serum_aminoacids 0.0395 1.22E-06 no up no up up no Cholinergic synapse Valine+blood 0 -0.658823529 0 yes kegg serum_aminoacids NA 1.22E-06 no no no up up no Creatinine+blood Valine+blood 0.69924812 0.676470588 0 yes serum_choline serum_aminoacids 0.437 1.22E-06 no no no up up no Cysteine+blood Valine+blood 0 0 0.48991453 yes yes serum_aminoacids serum_aminoacids 1.81E-07 1.22E-06 dn up up up up no Cystine+blood Valine+blood 0 0.531862745 0 yes yes serum_aminoacids serum_aminoacids 0.00028 1.22E-06 up up no up up no d18:0-16:0-SM+blood Valine+blood -0.57593985 0 0 yes serum_phospholipids serum_aminoacids 0.202 1.22E-06 no no no up up no d18:0-24:1-SM+blood Valine+blood -0.517293233 0 0 yes serum_phospholipids serum_aminoacids 0.0609 1.22E-06 no dn dn up up no d18:1-16:0-SM+blood Valine+blood -0.556390977 0 0 yes serum_phospholipids serum_aminoacids 0.14 1.22E-06 no no no up up no d18:1-16:1-SM+blood Valine+blood -0.613533835 0 0 yes serum_phospholipids serum_aminoacids 0.2 1.22E-06 no no no up up no d18:1-20:0-SM+blood Valine+blood -0.461654135 0 0 yes serum_phospholipids serum_aminoacids 0.933 1.22E-06 no no no up up no d18:1-22:1-SM+blood Valine+blood -0.601503759 0 0 yes serum_phospholipids serum_aminoacids 0.222 1.22E-06 no no no up up no DL-methionine sulfoxide+blood Valine+blood 0 0.556372549 0 yes serum_aminoacids serum_aminoacids 0.302 1.22E-06 no no no up up no DMG+blood Valine+blood 0 0 0.527521368 yes serum_choline serum_aminoacids 0.909 1.22E-06 no no no up up no ErbB signaling pathway Valine+blood 0 -0.611764706 0 yes kegg serum_aminoacids NA 1.22E-06 no no no up up no Ethanolamine+blood Valine+blood 0 0 0.52 yes serum_aminoacids serum_aminoacids 0.122 1.22E-06 up no no up up no Gastric cancer Valine+blood 0 -0.502941176 0 yes kegg serum_aminoacids NA 1.22E-06 no no no up up no GCDCA+stool Valine+blood 0 0.654545455 0 yes yes stool_bileacids serum_aminoacids 0.0471 1.22E-06 no dn no up up no GDCA+stool Valine+blood -0.626373626 0.820047686 0 yes stool_bileacids serum_aminoacids 0.656 1.22E-06 no no no up up no heptanoic acid C7+blood Valine+blood 0 0 0.534358974 yes serum_mcfa serum_aminoacids 8.27E-11 1.22E-06 dn dn no up up no iso-DCA+blood Valine+blood 0 0 0.516581197 yes serum_bileacids serum_aminoacids 0.38 1.22E-06 no no no up up no isobutyric acid C4+blood Valine+blood 0.535338346 0 0 yes serum_scfa serum_aminoacids 0.0151 1.22E-06 up up no up up no L-Alanine+blood Valine+blood 0 0.558823529 0 yes yes serum_aminoacids serum_aminoacids 0.00138 1.22E-06 up up no up up no L-Arginine+blood Valine+blood 0.664661654 0 0.404444444 yes serum_aminoacids serum_aminoacids 0.316 1.22E-06 no no no up up no L-Asparagine+blood Valine+blood 0.44962406 0.50245098 0 yes serum_aminoacids serum_aminoacids 0.784 1.22E-06 no no no up up no L-Citrulline+blood Valine+blood 0 0 0.535042735 yes serum_aminoacids serum_aminoacids 0.534 1.22E-06 no no no up up no L-Glutamic acid+blood Valine+blood 0 0.649509804 0.439316239 yes yes serum_aminoacids serum_aminoacids 6.20E-05 1.22E-06 up up no up up no L-Glutamine+blood Valine+blood 0.57593985 0.482843137 0 yes serum_aminoacids serum_aminoacids 0.639 1.22E-06 no no no up up no L-Histidine+blood Valine+blood 0.663157895 0 0.634871795 yes serum_aminoacids serum_aminoacids 0.109 1.22E-06 no no no up up no L-Isoleucine+blood Valine+blood 0.891729323 0.924019608 0.900854701 yes yes serum_aminoacids serum_aminoacids 5.47E-06 1.22E-06 up up no up up no L-Leucine+blood Valine+blood 0.705263158 0.759803922 0.842735043 yes yes serum_aminoacids serum_aminoacids 3.22E-05 1.22E-06 up up no up up no L-Lysine+blood Valine+blood 0.718796992 0.740196078 0.604786325 yes yes serum_aminoacids serum_aminoacids 0.0107 1.22E-06 no up no up up no L-Methionine+blood Valine+blood 0 0.860294118 0.431111111 yes serum_aminoacids serum_aminoacids 0.626 1.22E-06 no no no up up no L-Ornithine+blood Valine+blood 0 0 0.482393162 yes serum_aminoacids serum_aminoacids 0.175 1.22E-06 no no no up up no L-Phenylalanine+blood Valine+blood 0.560902256 0.715686275 0.808547009 yes yes serum_aminoacids serum_aminoacids 0.0103 1.22E-06 up up no up up no L-Threonine+blood Valine+blood 0 0.50245098 0 yes serum_aminoacids serum_aminoacids 0.0538 1.22E-06 dn no up up up no L-Tryptophan+blood Valine+blood 0.577443609 0.759803922 0.583589744 yes serum_aminoacids serum_aminoacids 0.164 1.22E-06 no no no up up no L-Tyrosine+blood Valine+blood 0 0.710784314 0.676581197 yes yes serum_aminoacids serum_aminoacids 0.00913 1.22E-06 up up no up up no Methanobrevibacter Valine+blood 0 0 0.514902851 yes Genus serum_aminoacids 0.629 1.22E-06 no no no up up no MUFA%+blood Valine+blood 0 0.556372549 0 yes serum_fattyacid serum_aminoacids 0.00142 1.22E-06 up no dn up up no Non-small cell lung cancer Valine+blood 0 -0.526470588 0 yes kegg serum_aminoacids NA 1.22E-06 no no no up up no octanoic acid C8+blood Valine+blood 0 0 0.442051282 yes serum_mcfa serum_aminoacids 2.84E-11 1.22E-06 dn dn dn up up no Oscillospira Valine+blood 0 0 0.420854701 LPS-producing yes Genus serum_aminoacids 0.62 1.22E-06 no no no up up no Parabacteroides Valine+blood 0 0 0.473927174 yes Genus serum_aminoacids 4.19E-05 1.22E-06 no up up up up no Phenylacetic acid+stool Valine+blood 0 -0.681818182 0 yes stool_cometabolism serum_aminoacids 0.785 1.22E-06 no no no up up no PUFA/UFA+blood Valine+blood 0.45112782 0 0 yes serum_fattyacid serum_aminoacids 0.000732 1.22E-06 dn no up up up no PUFA%+blood Valine+blood 0.457142857 0 0 yes serum_fattyacid serum_aminoacids 0.0013 1.22E-06 dn no up up up no Roseburia Valine+blood 0 0 -0.407863248 butyrate-producing yes Genus serum_aminoacids 0.495 1.22E-06 no no no up up no Sarcosine+blood Valine+blood 0 0.647058824 0 yes serum_choline serum_aminoacids 5.06E-05 1.22E-06 up up no up up no Serine+blood Valine+blood 0.533834586 0 0 yes serum_aminoacids serum_aminoacids 0.942 1.22E-06 no no no up up no SFA%+blood Valine+blood 0.491729323 0 0.444786325 yes serum_fattyacid serum_aminoacids 0.0236 1.22E-06 no up no up up no Taurine+blood Valine+blood 0 0 0.552136752 yes serum_aminoacids serum_aminoacids 0.857 1.22E-06 no no no up up no TCA+stool Valine+blood -0.607978567 0 0 yes stool_bileacids serum_aminoacids 0.458 1.22E-06 no no no up up no TXB2+blood Valine+blood 0 0 0.405822513 yes yes serum_ARA serum_aminoacids 0.0644 1.22E-06 dn no no up up no Viral myocarditis Valine+blood 0 0 -0.408461538 yes kegg serum_aminoacids NA 1.22E-06 no no no up up no "Alanine, aspartate and glutamate metabolism" Various types of N-glycan biosynthesis 0 -0.71541502 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Various types of N-glycan biosynthesis -0.416521739 -0.663043478 -0.40952381 kegg kegg NA NA no up no no no no Arginine biosynthesis Various types of N-glycan biosynthesis 0 -0.741106719 -0.50990991 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Various types of N-glycan biosynthesis 0 0.421936759 0.424453024 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Various types of N-glycan biosynthesis 0 0.677865613 0.644272844 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Various types of N-glycan biosynthesis 0.416521739 0.59486166 0.531788932 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Various types of N-glycan biosynthesis 0 -0.704545455 0 kegg kegg NA NA no no no no no no Glutathione metabolism Various types of N-glycan biosynthesis 0 0 -0.552123552 kegg kegg NA NA no no no no no no "Glycine, serine and threonine metabolism" Various types of N-glycan biosynthesis 0 0 -0.515315315 kegg kegg NA NA no up no no no no Lysine degradation Various types of N-glycan biosynthesis 0.466956522 0.555335968 0.605405405 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Various types of N-glycan biosynthesis 0.873043478 0.93083004 0.945431145 kegg kegg NA NA no no no no no no Other glycan degradation Various types of N-glycan biosynthesis 0 0 0.457657658 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Various types of N-glycan biosynthesis 0 0.780632411 0.574002574 kegg kegg NA NA no no no no no no Pentose phosphate pathway Various types of N-glycan biosynthesis -0.444347826 -0.593873518 -0.52972973 kegg kegg NA NA no no no no no no Phenylalanine metabolism Various types of N-glycan biosynthesis 0 0.551383399 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Various types of N-glycan biosynthesis 0 0.597826087 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Various types of N-glycan biosynthesis 0.529565217 0 0.64993565 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Various types of N-glycan biosynthesis 0 -0.649209486 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Various types of N-glycan biosynthesis 0.580869565 0.444664032 0.441441441 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Various types of N-glycan biosynthesis 0 0.640316206 0.556241956 kegg kegg NA NA no no no no no no Tryptophan metabolism Various types of N-glycan biosynthesis 0 0.473320158 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Various types of N-glycan biosynthesis 0 0.464426877 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Various types of N-glycan biosynthesis 0 0.617588933 0.516602317 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Various types of N-glycan biosynthesis 0 0.685770751 0.503217503 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Vascular smooth muscle contraction -0.428695652 0 0 kegg kegg NA NA no no no no no no ABC transporters Vascular smooth muscle contraction -0.675652174 -0.498023715 -0.416473616 kegg kegg NA NA no up up no no no Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction 0.817391304 0.772727273 0.618275418 kegg kegg NA NA no no up no no no "Alanine, aspartate and glutamate metabolism" Vascular smooth muscle contraction -0.566956522 -0.693675889 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Vascular smooth muscle contraction -0.665217391 -0.616600791 -0.491119691 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Vascular smooth muscle contraction -0.524347826 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Vascular smooth muscle contraction -0.648695652 0 0 kegg kegg NA NA no no no no no no Apoptosis Vascular smooth muscle contraction -0.493913043 -0.514822134 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Vascular smooth muscle contraction 0 -0.498023715 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Vascular smooth muscle contraction 0 0 0.444530245 kegg kegg NA NA no no no no no no Arginine and proline metabolism Vascular smooth muscle contraction -0.496521739 -0.651185771 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Vascular smooth muscle contraction -0.564347826 -0.605731225 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Vascular smooth muscle contraction 0 0 -0.463835264 kegg kegg NA NA no no no no no no Autophagy - animal Vascular smooth muscle contraction 0 -0.756916996 -0.428828829 kegg kegg NA NA no no no no no no Autophagy - other Vascular smooth muscle contraction 0 -0.527667984 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Vascular smooth muscle contraction -0.611304348 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Vascular smooth muscle contraction -0.593043478 -0.48715415 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Vascular smooth muscle contraction 0 0 0.469498069 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Vascular smooth muscle contraction -0.493913043 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Vascular smooth muscle contraction -0.419130435 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Vascular smooth muscle contraction 0.729565217 0.68083004 0.406435006 kegg kegg NA NA no up up no no no cAMP signaling pathway Vascular smooth muscle contraction 0.668695652 0 0.412612613 yes kegg kegg NA NA no up up no no no Carbon metabolism Vascular smooth muscle contraction -0.493043478 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Vascular smooth muscle contraction 0.66173913 0.828063241 0 kegg kegg NA NA no no up no no no cGMP-PKG signaling pathway Vascular smooth muscle contraction 0 -0.441699605 0 kegg kegg NA NA no no no no no no Coprococcus Vascular smooth muscle contraction 0 0 -0.55820838 butyrate-producing Genus kegg 0.612 NA no no no no no no Drug metabolism - cytochrome P450 Vascular smooth muscle contraction 0 0.45256917 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Vascular smooth muscle contraction 0 0.520750988 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Vascular smooth muscle contraction 0 0.476284585 0 kegg kegg NA NA no no no no no no Endocrine resistance Vascular smooth muscle contraction 0.463478261 0 0.43011583 kegg kegg NA NA no no no no no no ErbB signaling pathway Vascular smooth muscle contraction 0 -0.586956522 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Vascular smooth muscle contraction 0.633043478 0.450592885 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Vascular smooth muscle contraction -0.540869565 -0.708498024 0 kegg kegg NA NA no no no no no no Fatty acid degradation Vascular smooth muscle contraction -0.753043478 -0.748023715 -0.467696268 kegg kegg NA NA no no no no no no Fatty acid metabolism Vascular smooth muscle contraction -0.802608696 -0.647233202 0 kegg kegg NA NA no no no no no no Ferroptosis Vascular smooth muscle contraction 0.46 0 0.464092664 kegg kegg NA NA no no no no no no FoxO signaling pathway Vascular smooth muscle contraction 0 -0.742094862 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Vascular smooth muscle contraction -0.632173913 -0.586956522 -0.442728443 kegg kegg NA NA no no no no no no Galactose metabolism Vascular smooth muscle contraction -0.754782609 -0.725296443 -0.578893179 kegg kegg NA NA no no no no no no Glutathione metabolism Vascular smooth muscle contraction 0 0.623517787 0.480823681 kegg kegg NA NA no no no no no no Glycerolipid metabolism Vascular smooth muscle contraction -0.570434783 -0.626482213 -0.516602317 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Vascular smooth muscle contraction 0 0 0.468211068 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Vascular smooth muscle contraction -0.48 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Vascular smooth muscle contraction 0 -0.709486166 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Vascular smooth muscle contraction 0.586956522 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Vascular smooth muscle contraction 0 0 -0.496010296 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Vascular smooth muscle contraction -0.692173913 -0.626482213 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Vascular smooth muscle contraction 0 0.455533597 0 kegg kegg NA NA no no no no no no Histidine metabolism Vascular smooth muscle contraction -0.539130435 0 -0.491119691 kegg kegg NA NA no no no no no no Homologous recombination Vascular smooth muscle contraction -0.419130435 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Vascular smooth muscle contraction -0.507826087 -0.556324111 -0.41003861 kegg kegg NA NA no no no no no no Lachnospira Vascular smooth muscle contraction 0 0.506548076 0 butyrate-producing Genus kegg 0.279 NA no no no no no no MAPK signaling pathway Vascular smooth muscle contraction 0 -0.720355731 -0.468211068 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Vascular smooth muscle contraction 0 0.458498024 0 kegg kegg NA NA no no no no no no Mitophagy - animal Vascular smooth muscle contraction 0.79826087 0.660079051 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Vascular smooth muscle contraction 0.563478261 0.423913043 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Vascular smooth muscle contraction 0 0.451581028 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Vascular smooth muscle contraction 0 -0.503952569 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Vascular smooth muscle contraction 0 0.460474308 0 kegg kegg NA NA no no no no no no Necroptosis Vascular smooth muscle contraction 0.534782609 0 0.451737452 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Vascular smooth muscle contraction -0.636521739 -0.722332016 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Vascular smooth muscle contraction -0.509565217 -0.576086957 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Vascular smooth muscle contraction 0 -0.498023715 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Vascular smooth muscle contraction -0.502608696 0 0 kegg kegg NA NA no no no no no no Oocyte meiosis Vascular smooth muscle contraction 0.417391304 0.440711462 0 kegg kegg NA NA no no no no no no Oscillospira Vascular smooth muscle contraction 0 -0.562252964 0 LPS-producing Genus kegg 0.62 NA no no no no no no Other glycan degradation Vascular smooth muscle contraction -0.510434783 -0.593873518 -0.51994852 kegg kegg NA NA no no no no no no Oxidative phosphorylation Vascular smooth muscle contraction 0.691304348 0.875494071 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Vascular smooth muscle contraction -0.505217391 -0.58201581 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Vascular smooth muscle contraction 0 0.433794466 0 kegg kegg NA NA no no no no no no Peroxisome Vascular smooth muscle contraction -0.653913043 -0.633399209 0 kegg kegg NA NA no no no no no no Phagosome Vascular smooth muscle contraction -0.422608696 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Vascular smooth muscle contraction 0.412173913 0 0 kegg kegg NA NA no no no no no no Platinum drug resistance Vascular smooth muscle contraction 0 -0.483201581 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Vascular smooth muscle contraction 0 0 0.437065637 kegg kegg NA NA no no no no no no PPAR signaling pathway Vascular smooth muscle contraction 0 -0.627470356 0 kegg kegg NA NA no no no no no no Proteasome Vascular smooth muscle contraction 0 0.435770751 0 kegg kegg NA NA no no no no no no Protein export Vascular smooth muscle contraction 0.473913043 0.651185771 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Vascular smooth muscle contraction 0.448695652 0.453557312 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Vascular smooth muscle contraction -0.566956522 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Vascular smooth muscle contraction 0 0.447628458 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Vascular smooth muscle contraction 0 0.583992095 0 kegg kegg NA NA no no no no no no Ras signaling pathway Vascular smooth muscle contraction 0.413913043 0.565217391 0 yes kegg kegg NA NA no up up no no no Retinol metabolism Vascular smooth muscle contraction -0.496521739 0 0 kegg kegg NA NA no no no no no no Ribosome Vascular smooth muscle contraction 0.682608696 0.692687747 0 kegg kegg NA NA no no no no no no RNA degradation Vascular smooth muscle contraction 0.569565217 0.472332016 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Vascular smooth muscle contraction -0.544347826 -0.664031621 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Vascular smooth muscle contraction -0.554782609 -0.677865613 -0.464350064 kegg kegg NA NA no no no no no no Steroid biosynthesis Vascular smooth muscle contraction 0.439130435 0 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Vascular smooth muscle contraction 0 -0.506916996 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Vascular smooth muscle contraction -0.46173913 0 0 kegg kegg NA NA no up no no no no Ubiquitin mediated proteolysis Vascular smooth muscle contraction 0.79826087 0.669960474 0 kegg kegg NA NA no no no no no no ABC transporters Vasopressin-regulated water reabsorption -0.567826087 0 0 kegg kegg NA NA no up up no no no Adherens junction Vasopressin-regulated water reabsorption 0 0.558300395 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Vasopressin-regulated water reabsorption 0.709565217 0.804347826 0.691119691 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Vasopressin-regulated water reabsorption 0 -0.625494071 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Vasopressin-regulated water reabsorption -0.60173913 -0.654150198 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Vasopressin-regulated water reabsorption 0.890434783 0.852766798 0.805148005 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Vasopressin-regulated water reabsorption -0.589565217 -0.568181818 -0.554182754 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Vasopressin-regulated water reabsorption -0.411304348 0 -0.41029601 kegg kegg NA NA no no no no no no AMPK signaling pathway Vasopressin-regulated water reabsorption 0 0.419960474 0.432947233 kegg kegg NA NA no no no no no no Antigen processing and presentation Vasopressin-regulated water reabsorption -0.504347826 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Vasopressin-regulated water reabsorption 0 0.578063241 0 kegg kegg NA NA no no no no no no Apoptosis Vasopressin-regulated water reabsorption 0 -0.570158103 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Vasopressin-regulated water reabsorption 0 0.423913043 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Vasopressin-regulated water reabsorption -0.635652174 -0.601778656 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Vasopressin-regulated water reabsorption -0.594782609 -0.597826087 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Vasopressin-regulated water reabsorption 0 0 -0.56010296 kegg kegg NA NA no no no no no no Autophagy - animal Vasopressin-regulated water reabsorption 0 -0.64229249 -0.589189189 kegg kegg NA NA no no no no no no Autophagy - other Vasopressin-regulated water reabsorption 0 -0.433794466 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Vasopressin-regulated water reabsorption 0 -0.616600791 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Vasopressin-regulated water reabsorption -0.546956522 -0.660079051 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Vasopressin-regulated water reabsorption 0 0.445652174 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Vasopressin-regulated water reabsorption 0 -0.68083004 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Vasopressin-regulated water reabsorption 0.653043478 0.798418972 0.601801802 kegg kegg NA NA no up up no no no cAMP signaling pathway Vasopressin-regulated water reabsorption 0.499130435 0 0.481595882 yes kegg kegg NA NA no up up no no no Carbon metabolism Vasopressin-regulated water reabsorption -0.425217391 0 -0.433976834 kegg kegg NA NA no no no no no no Cardiac muscle contraction Vasopressin-regulated water reabsorption 0.569565217 0.757905138 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Vasopressin-regulated water reabsorption 0 -0.565217391 0 kegg kegg NA NA no no no no no no Cellular senescence Vasopressin-regulated water reabsorption 0 -0.468379447 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Vasopressin-regulated water reabsorption 0 -0.577075099 0 kegg kegg NA NA no no no no no no Circadian entrainment Vasopressin-regulated water reabsorption 0.73826087 0.793478261 0.87953668 kegg kegg NA NA no up up no no no Citrate cycle (TCA cycle) Vasopressin-regulated water reabsorption 0 0 -0.406949807 kegg kegg NA NA no no no no no no Complement and coagulation cascades Vasopressin-regulated water reabsorption -0.463478261 -0.527667984 0 kegg kegg NA NA no no no no no no Coprococcus Vasopressin-regulated water reabsorption 0 0 -0.407748247 butyrate-producing Genus kegg 0.612 NA no no no no no no Cortisol synthesis and secretion Vasopressin-regulated water reabsorption 0.847826087 0.694664032 0.846589447 kegg kegg NA NA no no up no no no Cushing syndrome Vasopressin-regulated water reabsorption 0.854782609 0.666007905 0.675675676 kegg kegg NA NA no no up no no no Dopaminergic synapse Vasopressin-regulated water reabsorption 0.687826087 0.889328063 0.713256113 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Vasopressin-regulated water reabsorption 0 0.438735178 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Vasopressin-regulated water reabsorption -0.420869565 0.422924901 -0.642213642 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Vasopressin-regulated water reabsorption 0 0.483201581 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Vasopressin-regulated water reabsorption 0.949565217 0.970355731 0.958301158 kegg kegg NA NA no no no no no no Endocrine resistance Vasopressin-regulated water reabsorption 0.808695652 0.56916996 0.686229086 kegg kegg NA NA no no no no no no Endocytosis Vasopressin-regulated water reabsorption 0 -0.528656126 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Vasopressin-regulated water reabsorption 0 0 0.594851995 kegg kegg NA NA no no no no no no Ether lipid metabolism Vasopressin-regulated water reabsorption 0.525217391 0 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Vasopressin-regulated water reabsorption -0.596521739 -0.67687747 -0.468983269 kegg kegg NA NA no no no no no no Fatty acid degradation Vasopressin-regulated water reabsorption -0.686086957 -0.753952569 -0.618790219 kegg kegg NA NA no no no no no no Fatty acid metabolism Vasopressin-regulated water reabsorption -0.686956522 -0.701581028 -0.496010296 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Vasopressin-regulated water reabsorption 0 -0.641304348 -0.424195624 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Vasopressin-regulated water reabsorption -0.52 -0.681818182 0 kegg kegg NA NA no no no no no no Ferroptosis Vasopressin-regulated water reabsorption 0.429565217 0 0 kegg kegg NA NA no no no no no no Focal adhesion Vasopressin-regulated water reabsorption 0 0.441699605 0 kegg kegg NA NA no up up no no no FoxO signaling pathway Vasopressin-regulated water reabsorption 0 -0.564229249 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Vasopressin-regulated water reabsorption -0.504347826 0 -0.611325611 kegg kegg NA NA no no no no no no GABAergic synapse Vasopressin-regulated water reabsorption -0.503478261 0 0 kegg kegg NA NA no up up no no no Galactose metabolism Vasopressin-regulated water reabsorption -0.493043478 -0.651185771 -0.685971686 kegg kegg NA NA no no no no no no Gap junction Vasopressin-regulated water reabsorption 0.779130435 0.546442688 0.776061776 kegg kegg NA NA no no no no no no Glucagon signaling pathway Vasopressin-regulated water reabsorption 0.726086957 0.813241107 0.574259974 kegg kegg NA NA no no no no no no Glutamatergic synapse Vasopressin-regulated water reabsorption 0.57826087 0 0.610810811 kegg kegg NA NA no up up no no no Glutathione metabolism Vasopressin-regulated water reabsorption 0 0.732213439 0.418532819 kegg kegg NA NA no no no no no no Glycerolipid metabolism Vasopressin-regulated water reabsorption -0.407826087 0 -0.446074646 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Vasopressin-regulated water reabsorption 0 0.455533597 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Vasopressin-regulated water reabsorption 0 -0.5 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Vasopressin-regulated water reabsorption 0 0 -0.407979408 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Vasopressin-regulated water reabsorption 0.547826087 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Vasopressin-regulated water reabsorption 0 -0.494071146 -0.652767053 kegg kegg NA NA no no up no no no Glyoxylate and dicarboxylate metabolism Vasopressin-regulated water reabsorption -0.715652174 -0.631422925 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Vasopressin-regulated water reabsorption 0.790434783 0.695652174 0.755727156 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Vasopressin-regulated water reabsorption 0.432173913 0 0.436808237 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Vasopressin-regulated water reabsorption 0.432173913 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Vasopressin-regulated water reabsorption 0.434782609 0.533596838 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Vasopressin-regulated water reabsorption 0 -0.564229249 -0.549292149 kegg kegg NA NA no no no no no no Histidine metabolism Vasopressin-regulated water reabsorption 0 0 -0.534105534 kegg kegg NA NA no no no no no no IL-17 signaling pathway Vasopressin-regulated water reabsorption -0.405217391 -0.580039526 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Vasopressin-regulated water reabsorption 0.800869565 0.853754941 0.797940798 kegg kegg NA NA no no no no no no Insulin resistance Vasopressin-regulated water reabsorption 0 -0.499011858 0 kegg kegg NA NA no no no no no no Insulin secretion Vasopressin-regulated water reabsorption 0.840869565 0.740118577 0.787387387 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Vasopressin-regulated water reabsorption 0 0.493083004 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Vasopressin-regulated water reabsorption 0 -0.58201581 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Vasopressin-regulated water reabsorption 0 0.456521739 0 kegg kegg NA NA no no no no no no Long-term depression Vasopressin-regulated water reabsorption 0.86173913 0.543478261 0.810810811 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Vasopressin-regulated water reabsorption 0 -0.4743083 0 kegg kegg NA NA no no no no no no Lysosome Vasopressin-regulated water reabsorption 0 -0.490118577 -0.492664093 kegg kegg NA NA no no no no no no MAPK signaling pathway Vasopressin-regulated water reabsorption 0 -0.57312253 -0.53976834 kegg kegg NA NA no no no no no no Melanogenesis Vasopressin-regulated water reabsorption 0.933043478 0.888339921 0.864350064 kegg kegg NA NA no no no no no no Mitophagy - animal Vasopressin-regulated water reabsorption 0.57826087 0.658102767 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Vasopressin-regulated water reabsorption 0 0.53458498 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Vasopressin-regulated water reabsorption 0 0.45256917 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Vasopressin-regulated water reabsorption 0 -0.511857708 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Vasopressin-regulated water reabsorption 0 0.494071146 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Vasopressin-regulated water reabsorption 0 -0.488142292 0 kegg kegg NA NA no no no no no no Necroptosis Vasopressin-regulated water reabsorption 0.554782609 0.414031621 0.432689833 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Vasopressin-regulated water reabsorption 0 -0.611660079 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Vasopressin-regulated water reabsorption 0 -0.5 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Vasopressin-regulated water reabsorption -0.436521739 -0.500988142 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Vasopressin-regulated water reabsorption -0.600869565 -0.616600791 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Vasopressin-regulated water reabsorption -0.648695652 -0.583003953 -0.442985843 kegg kegg NA NA no no no no no no Nitrogen metabolism Vasopressin-regulated water reabsorption -0.469565217 -0.451581028 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Vasopressin-regulated water reabsorption -0.712173913 -0.79743083 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Vasopressin-regulated water reabsorption 0.577391304 0.743083004 0.558558559 kegg kegg NA NA no no no no no no Notch signaling pathway Vasopressin-regulated water reabsorption 0 0 -0.422136422 kegg kegg NA NA no no no no no no Olfactory transduction Vasopressin-regulated water reabsorption 0 -0.472332016 -0.436550837 kegg kegg NA NA no no no no no no Oscillospira Vasopressin-regulated water reabsorption 0 -0.511857708 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Vasopressin-regulated water reabsorption -0.619130435 -0.779644269 0 kegg kegg NA NA no no no no no no Other glycan degradation Vasopressin-regulated water reabsorption -0.579130435 -0.425889328 -0.485714286 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Vasopressin-regulated water reabsorption 0.88173913 0.781620553 0.831402831 kegg kegg NA NA no up up no no no Oxidative phosphorylation Vasopressin-regulated water reabsorption 0.542608696 0.754940711 0.411583012 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Vasopressin-regulated water reabsorption -0.454782609 -0.656126482 -0.546203346 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Vasopressin-regulated water reabsorption 0.628695652 0.735177866 0.668725869 kegg kegg NA NA no no no no no no Pentose phosphate pathway Vasopressin-regulated water reabsorption 0 -0.558300395 0 kegg kegg NA NA no no no no no no Peroxisome Vasopressin-regulated water reabsorption -0.744347826 -0.767786561 0 kegg kegg NA NA no no no no no no Phagosome Vasopressin-regulated water reabsorption 0 -0.510869565 0 kegg kegg NA NA no no no no no no Platelet activation Vasopressin-regulated water reabsorption 0.46173913 0.572134387 0.47027027 kegg kegg NA NA no no no no no no PPAR signaling pathway Vasopressin-regulated water reabsorption -0.513913043 -0.77173913 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Vasopressin-regulated water reabsorption 0 -0.599802372 0 kegg kegg NA NA no no no no no no Proteasome Vasopressin-regulated water reabsorption 0 0 -0.496010296 kegg kegg NA NA no no no no no no Protein export Vasopressin-regulated water reabsorption 0 0.492094862 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Vasopressin-regulated water reabsorption 0 0.527667984 0 kegg kegg NA NA no no no no no no Purine metabolism Vasopressin-regulated water reabsorption 0 0.460474308 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Vasopressin-regulated water reabsorption -0.524347826 0.43972332 -0.521235521 kegg kegg NA NA no no no no no no Rap1 signaling pathway Vasopressin-regulated water reabsorption 0 0.470355731 0.410810811 kegg kegg NA NA no no no no no no Ras signaling pathway Vasopressin-regulated water reabsorption 0 0.519762846 0 yes kegg kegg NA NA no up up no no no Regulation of lipolysis in adipocytes Vasopressin-regulated water reabsorption 0.823478261 0.81027668 0.879279279 kegg kegg NA NA no no no no no no Relaxin signaling pathway Vasopressin-regulated water reabsorption 0 0 0.43989704 kegg kegg NA NA no no no no no no Renin secretion Vasopressin-regulated water reabsorption 0.783478261 0.87055336 0.884942085 kegg kegg NA NA no no no no no no Renin-angiotensin system Vasopressin-regulated water reabsorption 0 -0.605731225 -0.43963964 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Vasopressin-regulated water reabsorption 0 0.793478261 0 kegg kegg NA NA no no up no no no Ribosome Vasopressin-regulated water reabsorption 0.431304348 0.662055336 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Vasopressin-regulated water reabsorption -0.492173913 -0.627470356 0 kegg kegg NA NA no no no no no no RNA degradation Vasopressin-regulated water reabsorption 0 0.561264822 0 kegg kegg NA NA no no no no no no RNA polymerase Vasopressin-regulated water reabsorption 0 0.462450593 0 kegg kegg NA NA no no no no no no Serotonergic synapse Vasopressin-regulated water reabsorption 0.520869565 0.420948617 0.548519949 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Vasopressin-regulated water reabsorption -0.556521739 -0.587944664 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Vasopressin-regulated water reabsorption 0 0 -0.540797941 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Vasopressin-regulated water reabsorption 0 -0.509881423 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Vasopressin-regulated water reabsorption -0.556521739 -0.691699605 -0.690862291 kegg kegg NA NA no no no no no no Steroid biosynthesis Vasopressin-regulated water reabsorption 0.45826087 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Vasopressin-regulated water reabsorption 0 0 -0.501673102 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Vasopressin-regulated water reabsorption 0 -0.517786561 -0.516344916 kegg kegg NA NA no up up no no no T cell receptor signaling pathway Vasopressin-regulated water reabsorption 0 -0.644268775 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Vasopressin-regulated water reabsorption 0 0.483201581 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Vasopressin-regulated water reabsorption 0 -0.591897233 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Vasopressin-regulated water reabsorption 0 -0.656126482 0 kegg kegg NA NA no no no no no no Thermogenesis Vasopressin-regulated water reabsorption 0.645217391 0.756916996 0.45997426 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Vasopressin-regulated water reabsorption 0.412173913 0.639328063 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Vasopressin-regulated water reabsorption 0.688695652 0.849802372 0.732561133 kegg kegg NA NA no no no no no no TNF signaling pathway Vasopressin-regulated water reabsorption 0 -0.527667984 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Vasopressin-regulated water reabsorption 0 -0.634387352 0 yes kegg kegg NA NA no no no no no no Tryptophan metabolism Vasopressin-regulated water reabsorption 0 0 -0.436036036 kegg kegg NA NA no up no no no no Type I diabetes mellitus Vasopressin-regulated water reabsorption 0 -0.438735178 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Vasopressin-regulated water reabsorption 0 -0.42687747 -0.58996139 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Vasopressin-regulated water reabsorption 0.633913043 0.695652174 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Vasopressin-regulated water reabsorption 0.735652174 0.825098814 0.729214929 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Vasopressin-regulated water reabsorption 0 0 0.42960103 kegg kegg NA NA no no no no no no Wnt signaling pathway Vasopressin-regulated water reabsorption 0.571304348 0.563241107 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism VEGF signaling pathway -0.605217391 0 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes VEGF signaling pathway 0.423478261 0 0 kegg kegg NA NA no no up no no no alpha-Linolenic acid metabolism VEGF signaling pathway -0.449565217 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism VEGF signaling pathway -0.705217391 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis VEGF signaling pathway -0.507826087 -0.441699605 0 kegg kegg NA NA no no no no no no AMPK signaling pathway VEGF signaling pathway 0 0 -0.571943372 kegg kegg NA NA no no no no no no Antifolate resistance VEGF signaling pathway -0.460869565 0 0 kegg kegg NA NA no no no no no no Apoptosis VEGF signaling pathway 0 0.558300395 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism VEGF signaling pathway -0.748695652 0 -0.626512227 kegg kegg NA NA no no no no no no Arginine and proline metabolism VEGF signaling pathway 0 0.519762846 0 kegg kegg NA NA no up no no no no Arginine biosynthesis VEGF signaling pathway 0 0.418972332 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism VEGF signaling pathway -0.417391304 -0.555335968 0 kegg kegg NA NA no no no no no no Autophagy - animal VEGF signaling pathway 0.545217391 0.567193676 0.516602317 kegg kegg NA NA no no no no no no Autophagy - other VEGF signaling pathway 0 0 0.55984556 kegg kegg NA NA no no no no no no Axon guidance VEGF signaling pathway 0.666956522 0 0.564993565 kegg kegg NA NA no up up no no no Basal transcription factors VEGF signaling pathway 0 -0.451581028 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism VEGF signaling pathway -0.64173913 -0.581027668 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors VEGF signaling pathway -0.737391304 -0.462450593 -0.593050193 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids VEGF signaling pathway -0.450434783 -0.548418972 0 kegg kegg NA NA no no no no no no Butanoate metabolism VEGF signaling pathway -0.682608696 -0.605731225 0 kegg kegg NA NA no no no no no no Butyricimonas VEGF signaling pathway 0.47822921 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no Calcium signaling pathway VEGF signaling pathway 0.533043478 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway VEGF signaling pathway 0.628695652 0.446640316 0 yes kegg kegg NA NA no up up no no no Carbon metabolism VEGF signaling pathway -0.570434783 0 0 kegg kegg NA NA no no no no no no Cellular senescence VEGF signaling pathway 0 0.532608696 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway VEGF signaling pathway 0.6 0.421936759 0.548519949 kegg kegg NA NA no no no no no no Chemokine signaling pathway VEGF signaling pathway 0.486086957 0.62944664 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) VEGF signaling pathway -0.54 -0.686758893 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism VEGF signaling pathway -0.455652174 -0.583003953 0 kegg kegg NA NA no no no no no no DNA replication VEGF signaling pathway 0 -0.562252964 0 kegg kegg NA NA no no no no no no Dorea VEGF signaling pathway -0.44 0 0 Genus kegg 0.00362 NA up no dn no no no Drug metabolism - cytochrome P450 VEGF signaling pathway -0.540869565 -0.640316206 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes VEGF signaling pathway -0.706086957 -0.570158103 0 kegg kegg NA NA no no no no no no Endocytosis VEGF signaling pathway 0 0.415019763 0 kegg kegg NA NA no no no no no no ErbB signaling pathway VEGF signaling pathway 0.816521739 0.813241107 0.780694981 kegg kegg NA NA no no no no no no Ether lipid metabolism VEGF signaling pathway 0 -0.484189723 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis VEGF signaling pathway 0 0.449604743 0 kegg kegg NA NA no no no no no no Fatty acid elongation VEGF signaling pathway -0.459130435 -0.445652174 0 kegg kegg NA NA no no no no no no Ferroptosis VEGF signaling pathway 0 0 -0.54002574 kegg kegg NA NA no no no no no no Folate biosynthesis VEGF signaling pathway 0 0 0.406177606 kegg kegg NA NA no no no no no no Fructose and mannose metabolism VEGF signaling pathway -0.633043478 0 0 kegg kegg NA NA no no no no no no Galactose metabolism VEGF signaling pathway -0.491304348 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism VEGF signaling pathway -0.647826087 0 -0.751608752 kegg kegg NA NA no no no no no no Glycerolipid metabolism VEGF signaling pathway 0 0 0.498069498 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism VEGF signaling pathway 0 0 0.488545689 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" VEGF signaling pathway -0.533913043 0 -0.553667954 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis VEGF signaling pathway -0.709565217 -0.542490119 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate VEGF signaling pathway 0 0.665019763 0.584555985 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin VEGF signaling pathway -0.405217391 0 0.503217503 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate VEGF signaling pathway 0.429565217 0 0.531531532 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation VEGF signaling pathway 0 0 0.520978121 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series VEGF signaling pathway 0.56173913 0 0.497554698 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism VEGF signaling pathway 0 0.43083004 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway VEGF signaling pathway 0.554782609 0 0.546718147 kegg kegg NA NA no no no no no no Histidine metabolism VEGF signaling pathway -0.470434783 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism VEGF signaling pathway 0 0 0.448391248 kegg kegg NA NA no no no no no no Linoleic acid metabolism VEGF signaling pathway -0.559130435 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway VEGF signaling pathway 0 0 -0.468211068 kegg kegg NA NA no no no no no no Lysine degradation VEGF signaling pathway 0 0 0.490604891 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis VEGF signaling pathway 0.454782609 0 0.50990991 kegg kegg NA NA no no no no no no MAPK signaling pathway VEGF signaling pathway 0 0 0.763706564 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 VEGF signaling pathway -0.58 -0.67687747 0 kegg kegg NA NA no no no no no no Mismatch repair VEGF signaling pathway -0.517391304 -0.566205534 0 kegg kegg NA NA no no no no no no Mitophagy - animal VEGF signaling pathway 0 0 -0.595366795 kegg kegg NA NA no no no no no no mRNA surveillance pathway VEGF signaling pathway 0.467826087 0 0.473616474 kegg kegg NA NA no no no no no no N-Glycan biosynthesis VEGF signaling pathway 0 -0.427865613 0 kegg kegg NA NA no no no no no no Necroptosis VEGF signaling pathway 0 0 -0.526383526 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway VEGF signaling pathway 0 0.562252964 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism VEGF signaling pathway 0 0.505928854 0 kegg kegg NA NA no no no no no no Nitrogen metabolism VEGF signaling pathway 0 0.461462451 0 kegg kegg NA NA no no no no no no Non-homologous end-joining VEGF signaling pathway -0.549565217 -0.441699605 0 kegg kegg NA NA no no no no no no Notch signaling pathway VEGF signaling pathway 0.653043478 0.432806324 0.682110682 kegg kegg NA NA no no no no no no Nucleotide excision repair VEGF signaling pathway 0 -0.566205534 0 kegg kegg NA NA no no no no no no One carbon pool by folate VEGF signaling pathway 0 -0.480237154 0 kegg kegg NA NA no no no no no no Oocyte meiosis VEGF signaling pathway 0 -0.515810277 0.420592021 kegg kegg NA NA no no no no no no Other glycan degradation VEGF signaling pathway 0 0 0.417760618 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis VEGF signaling pathway 0 0 0.445045045 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions VEGF signaling pathway -0.610434783 -0.640316206 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism VEGF signaling pathway -0.590434783 -0.541501976 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system VEGF signaling pathway 0.606086957 0 0.636293436 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway VEGF signaling pathway 0.588695652 0.630434783 0 kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism VEGF signaling pathway -0.579130435 0 -0.62033462 kegg kegg NA NA no no no no no no PPAR signaling pathway VEGF signaling pathway 0 0.509881423 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis VEGF signaling pathway -0.533043478 -0.593873518 0 kegg kegg NA NA no no no no no no Propanoate metabolism VEGF signaling pathway -0.528695652 -0.591897233 0 kegg kegg NA NA no no no no no no Proteasome VEGF signaling pathway 0 -0.639328063 0 kegg kegg NA NA no no no no no no Protein export VEGF signaling pathway 0 -0.498023715 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum VEGF signaling pathway 0 -0.471343874 0 kegg kegg NA NA no no no no no no Purine metabolism VEGF signaling pathway -0.42173913 0 -0.481595882 kegg kegg NA NA no no no no no no Pyrimidine metabolism VEGF signaling pathway -0.622608696 -0.432806324 0 kegg kegg NA NA no no no no no no Pyruvate metabolism VEGF signaling pathway -0.54 -0.647233202 -0.474131274 kegg kegg NA NA no no no no no no Ras signaling pathway VEGF signaling pathway 0.43826087 0 0.607722008 yes kegg kegg NA NA no up up no no no Retinol metabolism VEGF signaling pathway -0.51826087 -0.499011858 0 kegg kegg NA NA no no no no no no Ribosome VEGF signaling pathway 0 -0.421936759 0 kegg kegg NA NA no no no no no no RNA degradation VEGF signaling pathway 0.473043478 0 0.474903475 kegg kegg NA NA no no no no no no RNA polymerase VEGF signaling pathway 0 -0.501976285 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway VEGF signaling pathway 0.884347826 0.640316206 0.833204633 kegg kegg NA NA no no no no no no Steroid biosynthesis VEGF signaling pathway 0 -0.713438735 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis VEGF signaling pathway -0.590434783 -0.578063241 0 kegg kegg NA NA no no no no no no Sulfur metabolism VEGF signaling pathway -0.610434783 0 -0.577606178 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies VEGF signaling pathway -0.429565217 -0.589920949 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis VEGF signaling pathway 0 -0.446640316 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway VEGF signaling pathway 0 -0.460474308 0.560617761 kegg kegg NA NA no no no no no no Thiamine metabolism VEGF signaling pathway -0.435652174 -0.531620553 0 kegg kegg NA NA no no no no no no Tryptophan metabolism VEGF signaling pathway -0.653913043 -0.660079051 0 kegg kegg NA NA no up no no no no Tyrosine metabolism VEGF signaling pathway -0.665217391 -0.605731225 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis VEGF signaling pathway -0.66173913 -0.563241107 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis VEGF signaling pathway 0 -0.46541502 -0.602059202 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" VEGF signaling pathway -0.634782609 -0.653162055 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction VEGF signaling pathway 0 -0.460474308 0 kegg kegg NA NA no no no no no no Wnt signaling pathway VEGF signaling pathway 0.473043478 0 0.673101673 kegg kegg NA NA no no no no no no ABC transporters Vibrio cholerae infection 0 -0.565217391 0 kegg kegg NA NA no up up no no no Adherens junction Vibrio cholerae infection 0.947826087 0.922924901 0.867696268 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Vibrio cholerae infection 0 -0.445652174 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Vibrio cholerae infection 0 0.459486166 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Vibrio cholerae infection -0.428695652 -0.530632411 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Vibrio cholerae infection 0 -0.612648221 0 kegg kegg NA NA no no no no no no Alistipes Vibrio cholerae infection 0 -0.507183328 0 Genus kegg 0.0114 NA no up no no no no Alzheimer disease Vibrio cholerae infection 0 0.615612648 0 kegg kegg NA NA no no no no no no Amphetamine addiction Vibrio cholerae infection 0 0.432806324 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Vibrio cholerae infection 0 0.624505929 0.51016731 kegg kegg NA NA no no no no no no Apelin signaling pathway Vibrio cholerae infection -0.409565217 0 0 kegg kegg NA NA no no no no no no Apoptosis Vibrio cholerae infection 0 0 0.504504505 kegg kegg NA NA no no no no no no Apoptosis - multiple species Vibrio cholerae infection -0.733913043 -0.634387352 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Vibrio cholerae infection 0 -0.520750988 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Vibrio cholerae infection 0 -0.540513834 0 kegg kegg NA NA no no no no no no Autophagy - animal Vibrio cholerae infection -0.704347826 -0.824110672 -0.611068211 kegg kegg NA NA no no no no no no Autophagy - other Vibrio cholerae infection -0.819130435 -0.840909091 -0.683655084 kegg kegg NA NA no no no no no no Axon guidance Vibrio cholerae infection 0 0 -0.43963964 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Vibrio cholerae infection 0 -0.460474308 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Vibrio cholerae infection 0.820869565 0.83201581 0.776576577 kegg kegg NA NA no no no no no no Basal transcription factors Vibrio cholerae infection -0.668695652 0 -0.52972973 kegg kegg NA NA no no no no no no Base excision repair Vibrio cholerae infection -0.735652174 0 0 kegg kegg NA NA no no no no no no Bifidobacterium Vibrio cholerae infection 0 0.445271301 0 acetate-producing Genus kegg 0.105 NA no dn no no no no Bile secretion Vibrio cholerae infection 0.54 0.641304348 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Vibrio cholerae infection -0.468695652 -0.571146245 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Vibrio cholerae infection 0 0.545454545 0 kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Vibrio cholerae infection -0.55826087 -0.451581028 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Vibrio cholerae infection 0 0.630434783 0.445817246 kegg kegg NA NA no no up no no no Cell cycle Vibrio cholerae infection -0.42173913 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Vibrio cholerae infection -0.462608696 0 0 kegg kegg NA NA no no no no no no Circadian entrainment Vibrio cholerae infection 0.492173913 0.743083004 0 kegg kegg NA NA no up up no no no Circadian rhythm Vibrio cholerae infection -0.484347826 0 -0.554440154 kegg kegg NA NA no no no no no no Collecting duct acid secretion Vibrio cholerae infection 0.439130435 0 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Vibrio cholerae infection 0 0 0.541312741 kegg kegg NA NA no no no no no no Dopaminergic synapse Vibrio cholerae infection 0 0.609683794 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Vibrio cholerae infection 0 0.52173913 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Vibrio cholerae infection 0 0.612648221 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Vibrio cholerae infection -0.459130435 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Vibrio cholerae infection 0.454782609 0.593873518 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Vibrio cholerae infection -0.456521739 -0.564229249 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Vibrio cholerae infection -0.436521739 0 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Vibrio cholerae infection 0 -0.535573123 0 kegg kegg NA NA no no no no no no Fatty acid degradation Vibrio cholerae infection 0 -0.589920949 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Vibrio cholerae infection 0 -0.523715415 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Vibrio cholerae infection 0 -0.41798419 0 kegg kegg NA NA no no no no no no Focal adhesion Vibrio cholerae infection 0.82 0.862648221 0.652252252 kegg kegg NA NA no up up no no no FoxO signaling pathway Vibrio cholerae infection -0.44 -0.754940711 0 kegg kegg NA NA no no no no no no GABAergic synapse Vibrio cholerae infection -0.417391304 -0.449604743 0 kegg kegg NA NA no up up no no no Gap junction Vibrio cholerae infection 0.497391304 0 0.415186615 kegg kegg NA NA no no no no no no Gastric acid secretion Vibrio cholerae infection 0.969565217 0.96541502 0.946718147 kegg kegg NA NA no no no no no no Glucagon signaling pathway Vibrio cholerae infection 0 0.418972332 0 kegg kegg NA NA no no no no no no Glutathione metabolism Vibrio cholerae infection 0 0.457509881 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism Vibrio cholerae infection 0 -0.552371542 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Vibrio cholerae infection -0.413913043 -0.517786561 0 kegg kegg NA NA no no up no no no Glycolysis / Gluconeogenesis Vibrio cholerae infection 0 0.444664032 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Vibrio cholerae infection 0 -0.56027668 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Vibrio cholerae infection 0.453913043 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Vibrio cholerae infection -0.407826087 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Vibrio cholerae infection 0 -0.552371542 0 kegg kegg NA NA no no no no no no GnRH secretion Vibrio cholerae infection 0 -0.517786561 0 kegg kegg NA NA no up up no no no HIF-1 signaling pathway Vibrio cholerae infection -0.57826087 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Vibrio cholerae infection 0.873043478 0.831027668 0.717631918 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Vibrio cholerae infection 0 -0.483201581 0 kegg kegg NA NA no no no no no no Homologous recombination Vibrio cholerae infection -0.453913043 -0.466403162 -0.432175032 kegg kegg NA NA no no no no no no Huntington disease Vibrio cholerae infection 0 0.625494071 0.433976834 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Vibrio cholerae infection 0 0.56916996 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Vibrio cholerae infection 0 -0.593873518 0 kegg kegg NA NA no no no no no no Insulin resistance Vibrio cholerae infection -0.634782609 -0.606719368 -0.485456885 kegg kegg NA NA no no no no no no Insulin signaling pathway Vibrio cholerae infection -0.484347826 0 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Vibrio cholerae infection 0 -0.703557312 0 kegg kegg NA NA no no no no no no Lachnospira Vibrio cholerae infection 0 0.630096387 0 butyrate-producing Genus kegg 0.279 NA no no no no no no Leukocyte transendothelial migration Vibrio cholerae infection 0.71826087 0.587944664 0.653539254 kegg kegg NA NA no no no no no no Long-term depression Vibrio cholerae infection 0.413043478 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Vibrio cholerae infection -0.407826087 0 0 kegg kegg NA NA no no up no no no Lysine degradation Vibrio cholerae infection -0.553043478 0 -0.431917632 kegg kegg NA NA no no no no no no MAPK signaling pathway Vibrio cholerae infection 0 -0.672924901 0 kegg kegg NA NA no no no no no no Melanogenesis Vibrio cholerae infection 0.497391304 0.598814229 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Vibrio cholerae infection 0 0.554347826 0 kegg kegg NA NA no no no no no no Morphine addiction Vibrio cholerae infection 0.422608696 0.601778656 0 kegg kegg NA NA no up up no no no mTOR signaling pathway Vibrio cholerae infection -0.436521739 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Vibrio cholerae infection 0 -0.734189723 -0.502187902 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Vibrio cholerae infection 0 -0.486166008 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Vibrio cholerae infection 0 0 0.463063063 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Vibrio cholerae infection -0.530434783 -0.671936759 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Vibrio cholerae infection 0 -0.436758893 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Vibrio cholerae infection 0 -0.505928854 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Vibrio cholerae infection 0 -0.678853755 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Vibrio cholerae infection 0 0.551383399 0.483655084 kegg kegg NA NA no no no no no no Oscillospira Vibrio cholerae infection 0 -0.473320158 0 LPS-producing Genus kegg 0.62 NA no no no no no no Osteoclast differentiation Vibrio cholerae infection 0 -0.482213439 0 kegg kegg NA NA no no no no no no Other glycan degradation Vibrio cholerae infection 0 -0.479249012 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Vibrio cholerae infection -0.504347826 0 -0.438352638 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Vibrio cholerae infection 0.58173913 0 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Vibrio cholerae infection 0 0.634387352 0.49034749 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Vibrio cholerae infection 0.875652174 0.827075099 0.743371943 kegg kegg NA NA no no no no no no p53 signaling pathway Vibrio cholerae infection -0.753913043 -0.575098814 -0.536164736 kegg kegg NA NA no no no no no no Pancreatic secretion Vibrio cholerae infection 0 0.716403162 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Vibrio cholerae infection 0 -0.460474308 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Vibrio cholerae infection 0 0.421936759 0 kegg kegg NA NA no no no no no no Parkinson disease Vibrio cholerae infection 0 0.572134387 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Vibrio cholerae infection 0 0.537549407 0 kegg kegg NA NA no no no no no no Peroxisome Vibrio cholerae infection 0 -0.552371542 0 kegg kegg NA NA no no no no no no Phagosome Vibrio cholerae infection 0 0 0.503732304 kegg kegg NA NA no no no no no no Phenylalanine metabolism Vibrio cholerae infection 0.597391304 0.531620553 0.489060489 kegg kegg NA NA no no no no no no Phototransduction Vibrio cholerae infection 0 0.504940711 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Vibrio cholerae infection -0.454782609 0 0 yes kegg kegg NA NA no up up no no no Platelet activation Vibrio cholerae infection 0.955652174 0.95256917 0.888545689 kegg kegg NA NA no no no no no no Platinum drug resistance Vibrio cholerae infection -0.768695652 -0.603754941 -0.447876448 kegg kegg NA NA no no no no no no PPAR signaling pathway Vibrio cholerae infection 0 -0.552371542 0 kegg kegg NA NA no no no no no no Prion disease Vibrio cholerae infection 0 0.595849802 0.457915058 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Vibrio cholerae infection -0.620869565 -0.584980237 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Vibrio cholerae infection 0 -0.421936759 0 kegg kegg NA NA no no no no no no Proteasome Vibrio cholerae infection -0.524347826 0 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Vibrio cholerae infection 0 -0.564229249 0 yes kegg kegg NA NA no up up no no no Protein export Vibrio cholerae infection -0.489565217 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Vibrio cholerae infection 0.904347826 0.899209486 0.9001287 kegg kegg NA NA no no no no no no Ras signaling pathway Vibrio cholerae infection 0 0.438735178 0 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton Vibrio cholerae infection 0.664347826 0.577075099 0.497812098 kegg kegg NA NA no no no no no no Renin secretion Vibrio cholerae infection 0.508695652 0.693675889 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Vibrio cholerae infection 0 0.647233202 0 kegg kegg NA NA no no up no no no Ribosome Vibrio cholerae infection 0 0.472332016 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Vibrio cholerae infection -0.592173913 0 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Vibrio cholerae infection -0.612173913 -0.709486166 0 kegg kegg NA NA no no no no no no RNA degradation Vibrio cholerae infection 0 0 -0.403861004 kegg kegg NA NA no no no no no no RNA polymerase Vibrio cholerae infection -0.647826087 0 0 kegg kegg NA NA no no no no no no RNA transport Vibrio cholerae infection -0.503478261 0 0 kegg kegg NA NA no no no no no no Salivary secretion Vibrio cholerae infection 0.497391304 0.647233202 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Vibrio cholerae infection -0.677391304 0 0 kegg kegg NA NA no no no no no no Serotonergic synapse Vibrio cholerae infection 0.407826087 0 0.433719434 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Vibrio cholerae infection 0 -0.46541502 -0.404633205 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Vibrio cholerae infection 0 -0.687747036 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Vibrio cholerae infection -0.754782609 0 -0.436808237 kegg kegg NA NA no no no no no no Spliceosome Vibrio cholerae infection -0.793043478 -0.627470356 -0.505276705 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Vibrio cholerae infection 0 -0.453557312 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Vibrio cholerae infection 0 -0.827075099 -0.569111969 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Vibrio cholerae infection 0 -0.502964427 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Vibrio cholerae infection -0.426956522 0 0 kegg kegg NA NA no no no no no no Thermogenesis Vibrio cholerae infection 0 0.624505929 0.480566281 kegg kegg NA NA no no no no no no Thiamine metabolism Vibrio cholerae infection 0 0 -0.427541828 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Vibrio cholerae infection 0.813913043 0.896245059 0.744144144 kegg kegg NA NA no no no no no no Tight junction Vibrio cholerae infection 0.787826087 0.834980237 0.696525097 kegg kegg NA NA no no no no no no TNF signaling pathway Vibrio cholerae infection 0 -0.571146245 0 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Vibrio cholerae infection 0 -0.492094862 0 yes kegg kegg NA NA no no no no no no Type II diabetes mellitus Vibrio cholerae infection -0.411304348 -0.644268775 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Vibrio cholerae infection 0 0.436758893 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Vibrio cholerae infection -0.53826087 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Vibrio cholerae infection 0 0.741106719 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Vibrio cholerae infection 0.506086957 0.678853755 0.414929215 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Vibrio cholerae infection 0 0 0.448391248 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Viral carcinogenesis 0 -0.508893281 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Viral carcinogenesis 0 0.56027668 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Viral carcinogenesis 0 0.415019763 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Viral carcinogenesis 0 -0.65513834 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption Viral carcinogenesis 0 0.520750988 0 kegg kegg NA NA no no no no no no Alzheimer disease Viral carcinogenesis 0 -0.505928854 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Viral carcinogenesis 0 0 -0.620592021 kegg kegg NA NA no no no no no no Amoebiasis Viral carcinogenesis 0.459130435 0.517786561 0 kegg kegg NA NA no no no no no no Amphetamine addiction Viral carcinogenesis -0.449565217 -0.817193676 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Viral carcinogenesis 0 -0.530632411 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Viral carcinogenesis 0 -0.551383399 0 kegg kegg NA NA no no no no no no Antifolate resistance Viral carcinogenesis 0 0 -0.401287001 kegg kegg NA NA no no no no no no Antigen processing and presentation Viral carcinogenesis 0.508695652 0 0.451737452 kegg kegg NA NA no no no no no no Apelin signaling pathway Viral carcinogenesis 0 -0.51284585 0 kegg kegg NA NA no no no no no no Apoptosis Viral carcinogenesis 0.54173913 0.839920949 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Viral carcinogenesis 0 0 -0.577091377 kegg kegg NA NA no no no no no no Arginine and proline metabolism Viral carcinogenesis 0 0.472332016 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Viral carcinogenesis 0 0.449604743 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Viral carcinogenesis -0.420869565 0 -0.486743887 kegg kegg NA NA no no no no no no Autophagy - animal Viral carcinogenesis 0 0.480237154 0 kegg kegg NA NA no no no no no no Axon guidance Viral carcinogenesis 0 0.422924901 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway Viral carcinogenesis 0 0.70256917 0.502960103 kegg kegg NA NA no no no no no no Basal transcription factors Viral carcinogenesis -0.673043478 -0.617588933 -0.505791506 kegg kegg NA NA no no no no no no Base excision repair Viral carcinogenesis -0.431304348 -0.497035573 -0.57992278 kegg kegg NA NA no no no no no no beta-Alanine metabolism Viral carcinogenesis 0 0 -0.482882883 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Viral carcinogenesis 0.52 0.64229249 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Viral carcinogenesis 0 -0.854743083 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Viral carcinogenesis 0 0 -0.531016731 kegg kegg NA NA no no no no no no Butanoate metabolism Viral carcinogenesis 0 -0.533596838 -0.507850708 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Viral carcinogenesis 0 0.778656126 0.494723295 kegg kegg NA NA no no no no no no cAMP signaling pathway Viral carcinogenesis 0 0.41798419 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Viral carcinogenesis 0 0.481225296 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Viral carcinogenesis 0 -0.428853755 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Viral carcinogenesis 0.844347826 0.90513834 0.794079794 kegg kegg NA NA no no no no no no Cell cycle Viral carcinogenesis -0.61826087 -0.654150198 0 kegg kegg NA NA no no no no no no Cellular senescence Viral carcinogenesis 0.935652174 0.976284585 0.964221364 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Viral carcinogenesis 0 0.605731225 0.402831403 kegg kegg NA NA no no no no no no Chagas disease Viral carcinogenesis 0 0.597826087 0.652767053 kegg kegg NA NA no no no no no no Chemokine signaling pathway Viral carcinogenesis 0.508695652 0.603754941 0.553410553 kegg kegg NA NA no no no no no no Cholesterol metabolism Viral carcinogenesis 0 0.608695652 0 yes kegg kegg NA NA no no up no no no Circadian entrainment Viral carcinogenesis 0 -0.615612648 0 kegg kegg NA NA no up up no no no Circadian rhythm Viral carcinogenesis 0 -0.425889328 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Viral carcinogenesis 0 -0.532608696 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Viral carcinogenesis 0.626086957 0.603754941 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Viral carcinogenesis 0 -0.420948617 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Viral carcinogenesis 0 -0.500988142 0 kegg kegg NA NA no no up no no no Cushing syndrome Viral carcinogenesis 0 -0.590909091 0 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism Viral carcinogenesis 0 -0.538537549 -0.432689833 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Viral carcinogenesis 0.409565217 0.517786561 0.651994852 kegg kegg NA NA no no no no no no DNA replication Viral carcinogenesis -0.50173913 -0.621541502 -0.466666667 kegg kegg NA NA no no no no no no Dopaminergic synapse Viral carcinogenesis 0 -0.666007905 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Viral carcinogenesis 0 -0.549407115 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Viral carcinogenesis 0 -0.539525692 0 kegg kegg NA NA no no no no no no Endocrine resistance Viral carcinogenesis 0 -0.419960474 0 kegg kegg NA NA no no no no no no Endocytosis Viral carcinogenesis 0.915652174 0.916007905 0.92020592 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Viral carcinogenesis 0.593043478 0.760869565 0.743629344 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Viral carcinogenesis 0.544347826 0 0.661003861 kegg kegg NA NA no no no no no no Estrogen signaling pathway Viral carcinogenesis -0.444347826 -0.717391304 -0.407464607 kegg kegg NA NA no no no no no no Ether lipid metabolism Viral carcinogenesis -0.494782609 -0.756916996 -0.476447876 kegg kegg NA NA no no no no no no Fanconi anemia pathway Viral carcinogenesis -0.504347826 -0.552371542 -0.53976834 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Viral carcinogenesis 0 0.469367589 0 kegg kegg NA NA no no no no no no Fatty acid elongation Viral carcinogenesis 0 0 -0.450965251 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Viral carcinogenesis 0 0.753952569 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Viral carcinogenesis 0 0.576086957 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Viral carcinogenesis 0 0 -0.495495495 kegg kegg NA NA no no no no no no Galactose metabolism Viral carcinogenesis 0 0.455533597 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Viral carcinogenesis 0 -0.730237154 0 kegg kegg NA NA no no no no no no Glutathione metabolism Viral carcinogenesis 0 -0.64229249 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Viral carcinogenesis -0.489565217 0 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Viral carcinogenesis 0 -0.731225296 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Viral carcinogenesis 0.484347826 0.552371542 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Viral carcinogenesis 0 0.509881423 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Viral carcinogenesis -0.466956522 0 -0.415958816 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Viral carcinogenesis 0 -0.665019763 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Viral carcinogenesis 0 0.491106719 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Viral carcinogenesis 0 -0.476284585 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Viral carcinogenesis -0.434782609 -0.427865613 0 kegg kegg NA NA no no no no no no Hepatitis B Viral carcinogenesis 0 0.540513834 0.431402831 kegg kegg NA NA no no no no no no Hepatitis C Viral carcinogenesis 0 0.595849802 0.437065637 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Viral carcinogenesis 0.442608696 0 0.536422136 kegg kegg NA NA no no no no no no Histidine metabolism Viral carcinogenesis 0 0 -0.475418275 kegg kegg NA NA no no no no no no Homologous recombination Viral carcinogenesis 0 0 -0.624967825 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Viral carcinogenesis 0.540869565 0.455533597 0.665122265 kegg kegg NA NA no no dn no no no Human immunodeficiency virus 1 infection Viral carcinogenesis 0.473913043 0.432806324 0.633719434 kegg kegg NA NA no no no no no no Human papillomavirus infection Viral carcinogenesis 0.934782609 0.957509881 0.958301158 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Viral carcinogenesis 0.53826087 0 0.571943372 kegg kegg NA NA no no no no no no Huntington disease Viral carcinogenesis 0 -0.516798419 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Viral carcinogenesis 0 0.616600791 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Viral carcinogenesis 0 -0.574110672 0 kegg kegg NA NA no no no no no no Influenza A Viral carcinogenesis 0.420869565 0.640316206 0 kegg kegg NA NA no no no no no no Insulin resistance Viral carcinogenesis 0 0.518774704 0 kegg kegg NA NA no no no no no no Insulin secretion Viral carcinogenesis 0 -0.461462451 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Viral carcinogenesis 0 -0.466403162 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Viral carcinogenesis 0.548695652 0 0 kegg kegg NA NA no no no no no no Long-term potentiation Viral carcinogenesis 0 -0.520750988 0 kegg kegg NA NA no no up no no no Longevity regulating pathway - multiple species Viral carcinogenesis 0 0 -0.417503218 kegg kegg NA NA no no no no no no Lysosome Viral carcinogenesis 0.413913043 0.636363636 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Viral carcinogenesis 0 -0.595849802 0 kegg kegg NA NA no up no no no no Melanogenesis Viral carcinogenesis 0 -0.546442688 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Viral carcinogenesis 0 -0.481225296 0 kegg kegg NA NA no no no no no no Mismatch repair Viral carcinogenesis -0.43826087 -0.713438735 -0.516859717 kegg kegg NA NA no no no no no no Mitophagy - animal Viral carcinogenesis 0 -0.499011858 0 kegg kegg NA NA no no no no no no Morphine addiction Viral carcinogenesis 0 -0.469367589 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway Viral carcinogenesis -0.508695652 -0.444664032 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Viral carcinogenesis -0.467826087 -0.538537549 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Viral carcinogenesis 0.891304348 0.947628458 0.878249678 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Viral carcinogenesis 0 0.562252964 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway Viral carcinogenesis 0 0.731225296 0.601801802 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Viral carcinogenesis 0.493913043 0.593873518 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Viral carcinogenesis 0 0.54743083 0.406435006 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Viral carcinogenesis 0 0.535573123 0 kegg kegg NA NA no no no no no no Nicotine addiction Viral carcinogenesis 0 0 0.424967825 kegg kegg NA NA no up up no no no Nitrogen metabolism Viral carcinogenesis 0.509565217 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Viral carcinogenesis 0 0.720355731 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Viral carcinogenesis 0 -0.416007905 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Viral carcinogenesis -0.546956522 -0.740118577 -0.693693694 kegg kegg NA NA no no no no no no One carbon pool by folate Viral carcinogenesis -0.575652174 -0.706521739 -0.451222651 kegg kegg NA NA no no no no no no Oocyte meiosis Viral carcinogenesis -0.545217391 -0.456521739 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Viral carcinogenesis 0 0.745059289 0.442728443 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Viral carcinogenesis -0.444347826 0 0 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Viral carcinogenesis 0 -0.420948617 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Viral carcinogenesis 0 -0.495059289 0 kegg kegg NA NA no no no no no no p53 signaling pathway Viral carcinogenesis -0.486086957 0 -0.486229086 kegg kegg NA NA no no no no no no Pancreatic secretion Viral carcinogenesis 0 -0.447628458 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Viral carcinogenesis 0 0.432806324 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Viral carcinogenesis 0 -0.473320158 0 kegg kegg NA NA no no no no no no Parkinson disease Viral carcinogenesis 0 -0.491106719 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Viral carcinogenesis 0.547826087 0.748023715 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Viral carcinogenesis 0 -0.520750988 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Viral carcinogenesis 0 -0.555335968 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Viral carcinogenesis 0.600869565 0.647233202 0 kegg kegg NA NA no no no no no no Pertussis Viral carcinogenesis 0 0.67687747 0 kegg kegg NA NA no no dn no no no Phagosome Viral carcinogenesis 0.806086957 0.852766798 0.668211068 kegg kegg NA NA no no no no no no Phenylalanine metabolism Viral carcinogenesis 0 -0.457509881 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Viral carcinogenesis -0.417391304 0 0 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Viral carcinogenesis 0 0.456521739 0 kegg kegg NA NA no up up no no no Platinum drug resistance Viral carcinogenesis 0 0 -0.583526384 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Viral carcinogenesis 0 -0.709486166 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Viral carcinogenesis 0.417391304 0.654150198 0.571943372 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Viral carcinogenesis -0.484347826 0 -0.468468468 kegg kegg NA NA no no no no no no Prion disease Viral carcinogenesis 0 -0.505928854 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Viral carcinogenesis 0 0.677865613 0 kegg kegg NA NA no no no no no no Propanoate metabolism Viral carcinogenesis 0 -0.52173913 -0.465894466 kegg kegg NA NA no no no no no no Protein digestion and absorption Viral carcinogenesis 0 0.540513834 0 yes kegg kegg NA NA no up up no no no Protein export Viral carcinogenesis -0.595652174 -0.416007905 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Viral carcinogenesis 0 -0.593873518 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Viral carcinogenesis -0.451304348 -0.62055336 -0.461518662 kegg kegg NA NA no no no no no no Purine metabolism Viral carcinogenesis 0 -0.682806324 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Viral carcinogenesis 0 -0.610671937 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Viral carcinogenesis 0 -0.627470356 -0.57966538 kegg kegg NA NA no no no no no no Rap1 signaling pathway Viral carcinogenesis 0.417391304 0 0 kegg kegg NA NA no no no no no no Ras signaling pathway Viral carcinogenesis 0 -0.420948617 0 yes kegg kegg NA NA no up up no no no Relaxin signaling pathway Viral carcinogenesis 0 0.429841897 0 kegg kegg NA NA no no no no no no Renin secretion Viral carcinogenesis 0 -0.626482213 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Viral carcinogenesis 0 0.694664032 0 kegg kegg NA NA no no no no no no Retinol metabolism Viral carcinogenesis 0 -0.558300395 -0.556756757 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Viral carcinogenesis 0 -0.505928854 0 kegg kegg NA NA no no up no no no Ribosome Viral carcinogenesis 0 -0.434782609 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Viral carcinogenesis -0.557391304 -0.59486166 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Viral carcinogenesis 0 0.558300395 0.466924067 kegg kegg NA NA no no no no no no RNA degradation Viral carcinogenesis -0.513913043 -0.4743083 0 kegg kegg NA NA no no no no no no RNA polymerase Viral carcinogenesis -0.554782609 -0.660079051 -0.44015444 kegg kegg NA NA no no no no no no Salmonella infection Viral carcinogenesis 0 0.601778656 0 kegg kegg NA NA no no no no no no Sarcina Viral carcinogenesis 0 0.422326513 0 Genus kegg 0.0703 NA no no no no no no Selenocompound metabolism Viral carcinogenesis -0.535652174 -0.420948617 -0.538996139 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Viral carcinogenesis 0 0.789525692 0 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Viral carcinogenesis 0 0.638339921 0 kegg kegg NA NA up no no no no no Starch and sucrose metabolism Viral carcinogenesis 0 0.429841897 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Viral carcinogenesis -0.788695652 -0.613636364 -0.510939511 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Viral carcinogenesis 0 -0.630434783 -0.415958816 kegg kegg NA NA no no no no no no Sulfur metabolism Viral carcinogenesis 0 -0.43972332 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Viral carcinogenesis 0 0.441699605 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Viral carcinogenesis -0.488695652 -0.732213439 -0.562934363 kegg kegg NA NA no no no no no no Taste transduction Viral carcinogenesis -0.563478261 -0.698616601 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Viral carcinogenesis -0.406956522 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Viral carcinogenesis -0.788695652 -0.423913043 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Viral carcinogenesis -0.460869565 0 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Viral carcinogenesis 0 0.605731225 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Viral carcinogenesis 0 0.613636364 0 kegg kegg NA NA no no no no no no Thermogenesis Viral carcinogenesis 0 -0.528656126 0 kegg kegg NA NA no no no no no no Thiamine metabolism Viral carcinogenesis 0 -0.668972332 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Viral carcinogenesis 0 -0.450592885 0 kegg kegg NA NA no no no no no no TNF signaling pathway Viral carcinogenesis 0 0.673913043 0.652509653 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Viral carcinogenesis 0.410434783 0.735177866 0.721492921 yes kegg kegg NA NA no no no no no no Toxoplasmosis Viral carcinogenesis 0 0.552371542 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Viral carcinogenesis 0 0.414031621 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Viral carcinogenesis 0 0 -0.445302445 kegg kegg NA NA no up no no no no Tuberculosis Viral carcinogenesis 0 0.650197628 0 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Viral carcinogenesis 0.803478261 0.918972332 0.858172458 kegg kegg NA NA no no no no no no Tyrosine metabolism Viral carcinogenesis 0 -0.683794466 -0.604890605 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Viral carcinogenesis -0.46173913 -0.626482213 -0.593822394 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Viral carcinogenesis 0 -0.596837945 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Viral carcinogenesis 0 -0.604743083 -0.572715573 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Viral carcinogenesis 0 -0.529644269 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Viral carcinogenesis 0 -0.545454545 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Viral carcinogenesis 0 0.588932806 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Viral carcinogenesis 0.422608696 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Viral carcinogenesis -0.529565217 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Viral carcinogenesis 0 -0.497035573 0 kegg kegg NA NA no no no no no no Yersinia infection Viral carcinogenesis 0.44173913 0.683794466 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Viral myocarditis 0.480869565 0 0 kegg kegg NA NA no no no no no no Adherens junction Viral myocarditis 0.492173913 0 0.473359073 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Viral myocarditis 0 -0.524703557 0 kegg kegg NA NA no up up no no no Allograft rejection Viral myocarditis 0.972173913 0.967391304 0.958815959 kegg kegg NA NA no no no no no no Alzheimer disease Viral myocarditis -0.476521739 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Viral myocarditis 0 -0.571146245 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Viral myocarditis 0 -0.612648221 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Viral myocarditis -0.409565217 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Viral myocarditis 0 0 -0.454826255 kegg kegg NA NA no no no no no no Antigen processing and presentation Viral myocarditis 0 0.508893281 0.608751609 kegg kegg NA NA no no no no no no Apelin signaling pathway Viral myocarditis -0.540869565 0 0 kegg kegg NA NA no no no no no no Apoptosis Viral myocarditis 0.475652174 0.614624506 0.450707851 kegg kegg NA NA no no no no no no Apoptosis - multiple species Viral myocarditis 0 0 -0.572715573 kegg kegg NA NA no no no no no no Arrhythmogenic right ventricular cardiomyopathy Viral myocarditis 0.56173913 0 0.494465894 kegg kegg NA NA no up up no no no Asthma Viral myocarditis 0.412173913 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Viral myocarditis 0.972173913 0.967391304 0.958815959 kegg kegg NA NA no no no no no no Autophagy - animal Viral myocarditis -0.45826087 0 0 kegg kegg NA NA no no no no no no Autophagy - other Viral myocarditis -0.68173913 0 -0.424195624 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Viral myocarditis 0.534782609 0.486166008 0.479021879 kegg kegg NA NA no no no no no no Basal transcription factors Viral myocarditis -0.696521739 -0.599802372 -0.645817246 kegg kegg NA NA no no no no no no Base excision repair Viral myocarditis -0.412173913 -0.528656126 -0.508622909 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Viral myocarditis 0.56 0.502964427 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Viral myocarditis 0 -0.772727273 0 kegg kegg NA NA no no no no no no Butyricicoccus Viral myocarditis 0 0 0.484557649 butyrate-producing Genus kegg 0.852 NA no no no no no no cAMP signaling pathway Viral myocarditis -0.417391304 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Viral myocarditis 0.484347826 0.494071146 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Viral myocarditis 0.929565217 0.912055336 0.947490347 kegg kegg NA NA no no no no no no Cell cycle Viral myocarditis -0.668695652 -0.559288538 0 kegg kegg NA NA no no no no no no Cellular senescence Viral myocarditis 0.782608696 0.875494071 0.812097812 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Viral myocarditis 0 0 -0.492921493 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Viral myocarditis 0 0.432806324 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Viral myocarditis -0.469565217 -0.603754941 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Viral myocarditis 0 0 0.544144144 kegg kegg NA NA no no no no no no Cholesterol metabolism Viral myocarditis 0 0.677865613 0 yes kegg kegg NA NA no no up no no no Cholinergic synapse Viral myocarditis -0.413043478 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Viral myocarditis -0.54173913 -0.510869565 0 kegg kegg NA NA no no no no no no Cocaine addiction Viral myocarditis 0 -0.475296443 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Viral myocarditis 0.491304348 0.494071146 0.450965251 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Viral myocarditis 0 -0.604743083 0 kegg kegg NA NA no no up no no no Cushing syndrome Viral myocarditis 0 -0.669960474 0 kegg kegg NA NA no no up no no no Dilated cardiomyopathy Viral myocarditis 0.502608696 0 0 kegg kegg NA NA no up up no no no DNA replication Viral myocarditis 0 0 -0.431145431 kegg kegg NA NA no no no no no no Dopaminergic synapse Viral myocarditis -0.433043478 0 0 kegg kegg NA NA no up no no no no Endocrine resistance Viral myocarditis 0 -0.544466403 0 kegg kegg NA NA no no no no no no Endocytosis Viral myocarditis 0.79826087 0.896245059 0.859459459 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Viral myocarditis 0 0.464426877 0.522007722 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Viral myocarditis 0 0.520750988 0.642985843 kegg kegg NA NA no no no no no no Estrogen signaling pathway Viral myocarditis -0.436521739 -0.443675889 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Viral myocarditis -0.411304348 -0.625494071 0 kegg kegg NA NA no no no no no no Eubacterium Viral myocarditis 0 0 -0.412239157 Genus kegg 0.0692 NA no no no no no no Fanconi anemia pathway Viral myocarditis -0.46 -0.56916996 -0.543886744 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Viral myocarditis 0 0.464426877 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Viral myocarditis 0 0.468379447 0 kegg kegg NA NA no no no no no no Focal adhesion Viral myocarditis 0.513913043 0 0.423166023 kegg kegg NA NA no up up no no no Folate biosynthesis Viral myocarditis -0.412173913 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Viral myocarditis 0 0 -0.518918919 kegg kegg NA NA no no no no no no Glucagon signaling pathway Viral myocarditis 0 -0.530632411 0 kegg kegg NA NA no no no no no no Glutathione metabolism Viral myocarditis 0 -0.415019763 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Viral myocarditis -0.470434783 -0.562252964 -0.403603604 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Viral myocarditis 0 -0.704545455 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Viral myocarditis 0.499130435 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Viral myocarditis 0 0.583003953 0 kegg kegg NA NA no no up no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Viral myocarditis 0 -0.732213439 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Viral myocarditis 0 -0.52173913 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Viral myocarditis 0.969565217 0.967391304 0.95958816 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Viral myocarditis 0 -0.437747036 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Viral myocarditis 0.549565217 0 0.407722008 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Viral myocarditis 0 0.482213439 0.603603604 kegg kegg NA NA no no no no no no Hippo signaling pathway Viral myocarditis 0 0 0.425997426 kegg kegg NA NA no no no no no no Homologous recombination Viral myocarditis -0.415652174 -0.556324111 -0.612097812 kegg kegg NA NA no no no no no no Human cytomegalovirus infection Viral myocarditis 0 0.498023715 0.594079794 kegg kegg NA NA no no dn no no no Human immunodeficiency virus 1 infection Viral myocarditis 0 0.500988142 0.564221364 kegg kegg NA NA no no no no no no Human papillomavirus infection Viral myocarditis 0.816521739 0.838932806 0.79047619 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Viral myocarditis 0 0.489130435 0.634234234 kegg kegg NA NA no no no no no no Huntington disease Viral myocarditis -0.453043478 0 0 kegg kegg NA NA no no no no no no Hypertrophic cardiomyopathy Viral myocarditis 0.608695652 0 0.488545689 kegg kegg NA NA no up up no no no IL-17 signaling pathway Viral myocarditis 0 0.492094862 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Viral myocarditis 0 0.424901186 0 kegg kegg NA NA no no no no no no Influenza A Viral myocarditis 0.688695652 0.838932806 0.677734878 kegg kegg NA NA no no no no no no Insulin resistance Viral myocarditis -0.510434783 0 0 kegg kegg NA NA no no no no no no Insulin secretion Viral myocarditis 0 -0.530632411 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Viral myocarditis -0.526956522 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Viral myocarditis 0 0.469367589 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Viral myocarditis 0.611304348 0.583003953 0.594851995 kegg kegg NA NA no no no no no no Long-term potentiation Viral myocarditis -0.546956522 0 0 kegg kegg NA NA no no up no no no Longevity regulating pathway Viral myocarditis 0 -0.473320158 0 kegg kegg NA NA no no no no no no Lysosome Viral myocarditis 0 0.67687747 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Viral myocarditis -0.605217391 0 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Viral myocarditis 0 -0.46541502 0 kegg kegg NA NA no up no no no no Measles Viral myocarditis -0.534782609 0 0 kegg kegg NA NA no no no no no no Mismatch repair Viral myocarditis 0 -0.504940711 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Viral myocarditis -0.599130435 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Viral myocarditis 0.807826087 0.89229249 0.843500644 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Viral myocarditis 0 0.557312253 0 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Viral myocarditis 0.452173913 0.572134387 0.472844273 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Viral myocarditis -0.470434783 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Viral myocarditis 0 -0.54743083 -0.552123552 kegg kegg NA NA no no no no no no One carbon pool by folate Viral myocarditis 0 -0.459486166 0 kegg kegg NA NA no no no no no no Oocyte meiosis Viral myocarditis -0.595652174 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Viral myocarditis 0 0.458498024 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Viral myocarditis -0.564347826 -0.56916996 -0.500643501 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Viral myocarditis 0 -0.422924901 0 kegg kegg NA NA no up up no no no Oxidative phosphorylation Viral myocarditis -0.424347826 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Viral myocarditis 0.444347826 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Viral myocarditis -0.600869565 -0.538537549 -0.642213642 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Viral myocarditis 0.471304348 0.725296443 0.64015444 kegg kegg NA NA no no no no no no Pathways in cancer Viral myocarditis -0.571304348 0 -0.496782497 kegg kegg NA NA no no no no no no Pentose phosphate pathway Viral myocarditis 0.512173913 0.613636364 0 kegg kegg NA NA no no no no no no Pertussis Viral myocarditis 0 0.557312253 0 kegg kegg NA NA no no dn no no no Phagosome Viral myocarditis 0.89826087 0.872529644 0.881853282 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Viral myocarditis -0.419130435 -0.420948617 -0.417503218 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Viral myocarditis -0.572173913 0 0 yes kegg kegg NA NA no up up no no no Platelet activation Viral myocarditis 0.422608696 0 0.469498069 kegg kegg NA NA no no no no no no Platinum drug resistance Viral myocarditis -0.431304348 0 -0.613899614 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Viral myocarditis 0 -0.65513834 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Viral myocarditis 0 -0.549407115 0 kegg kegg NA NA no no no no no no Prion disease Viral myocarditis -0.426086957 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Viral myocarditis -0.495652174 0 -0.447619048 kegg kegg NA NA no no no no no no Protein export Viral myocarditis -0.625217391 0 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Viral myocarditis 0 0 -0.423166023 kegg kegg NA NA no no no no no no Purine metabolism Viral myocarditis 0 -0.661067194 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Viral myocarditis 0.513913043 0.488142292 0.523294723 kegg kegg NA NA no no no no no no Renin-angiotensin system Viral myocarditis 0 0.576086957 0 kegg kegg NA NA no no no no no no Retinol metabolism Viral myocarditis 0 -0.416007905 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Viral myocarditis -0.506956522 0 0 kegg kegg NA NA no no up no no no Rheumatoid arthritis Viral myocarditis 0.637391304 0.675889328 0.501415701 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Viral myocarditis -0.515652174 -0.504940711 -0.439382239 kegg kegg NA NA no no no no no no RNA degradation Viral myocarditis -0.513913043 0 0 kegg kegg NA NA no no no no no no RNA polymerase Viral myocarditis -0.562608696 -0.516798419 -0.404375804 kegg kegg NA NA no no no no no no Salmonella infection Viral myocarditis 0 0.666996047 0.502960103 kegg kegg NA NA no no no no no no Selenocompound metabolism Viral myocarditis -0.59826087 -0.60770751 -0.548262548 kegg kegg NA NA no no no no no no Sphingolipid metabolism Viral myocarditis 0 0.468379447 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Viral myocarditis 0 0.662055336 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Viral myocarditis -0.464347826 0 0 kegg kegg NA NA no no no no no no Spliceosome Viral myocarditis -0.536521739 0 -0.451994852 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Viral myocarditis 0.572173913 0.68972332 0.438095238 kegg kegg NA NA up no no no no no Steroid biosynthesis Viral myocarditis -0.602608696 0 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Viral myocarditis 0 -0.558300395 -0.434749035 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Viral myocarditis 0 0.639328063 0 kegg kegg NA NA no no no no no no Taste transduction Viral myocarditis -0.629565217 -0.574110672 0 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Viral myocarditis -0.407826087 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Viral myocarditis -0.750434783 0 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Viral myocarditis 0 0.516798419 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Viral myocarditis 0 0.463438735 0 kegg kegg NA NA no no no no no no Thiamine metabolism Viral myocarditis 0 -0.5256917 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Viral myocarditis 0.472173913 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Viral myocarditis 0 -0.436758893 0 kegg kegg NA NA no no no no no no Tight junction Viral myocarditis 0.413913043 0 0.41029601 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Viral myocarditis 0 0 0.42007722 yes kegg kegg NA NA no no no no no no Toxoplasmosis Viral myocarditis 0 0.473320158 0 kegg kegg NA NA no no no no no no Tuberculosis Viral myocarditis 0.483478261 0.636363636 0 kegg kegg NA NA no no dn no no no Type I diabetes mellitus Viral myocarditis 0.972173913 0.966403162 0.957786358 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Viral myocarditis 0 -0.414031621 -0.424710425 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Viral myocarditis 0 -0.461462451 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Viral myocarditis -0.419130435 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Viral myocarditis 0 0 0.485714286 kegg kegg NA NA no no no no no no Viral carcinogenesis Viral myocarditis 0.783478261 0.836956522 0.786615187 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Viral myocarditis -0.487826087 0 0 kegg kegg NA NA no no no no no no Yersinia infection Viral myocarditis 0 0.68972332 0.55958816 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Viral protein interaction with cytokine and cytokine receptor 0 -0.515810277 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Viral protein interaction with cytokine and cytokine receptor 0 -0.637351779 0 kegg kegg NA NA no no no no no no Antifolate resistance Viral protein interaction with cytokine and cytokine receptor -0.453913043 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Viral protein interaction with cytokine and cytokine receptor 0 0.643280632 0 kegg kegg NA NA no no no no no no Arginine and proline metabolism Viral protein interaction with cytokine and cytokine receptor 0 0.422924901 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Viral protein interaction with cytokine and cytokine receptor 0 0.428853755 0 kegg kegg NA NA no no no no no no Basal transcription factors Viral protein interaction with cytokine and cytokine receptor 0 -0.537549407 0 kegg kegg NA NA no no no no no no Base excision repair Viral protein interaction with cytokine and cytokine receptor 0 -0.499011858 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Viral protein interaction with cytokine and cytokine receptor 0 0.453557312 0 kegg kegg NA NA no no no no no no Butyricimonas Viral protein interaction with cytokine and cytokine receptor 0.460855682 0 0 butyrate-producing Genus kegg 0.17 NA no no no no no no Calcium signaling pathway Viral protein interaction with cytokine and cytokine receptor 0.41826087 0 0 kegg kegg NA NA no up up no no no cGMP-PKG signaling pathway Viral protein interaction with cytokine and cytokine receptor 0 0.570158103 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor 0.806086957 0.763833992 0.761132561 kegg kegg NA NA no no no no no no DNA replication Viral protein interaction with cytokine and cytokine receptor 0 -0.459486166 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Viral protein interaction with cytokine and cytokine receptor 0 0 -0.53976834 kegg kegg NA NA no no no no no no Ether lipid metabolism Viral protein interaction with cytokine and cytokine receptor 0 -0.416996047 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Viral protein interaction with cytokine and cytokine receptor -0.414782609 -0.649209486 0 kegg kegg NA NA no no no no no no Folate biosynthesis Viral protein interaction with cytokine and cytokine receptor -0.443478261 -0.52173913 0 kegg kegg NA NA no no no no no no Galactose metabolism Viral protein interaction with cytokine and cytokine receptor -0.424347826 0 0 kegg kegg NA NA no no no no no no Glutathione metabolism Viral protein interaction with cytokine and cytokine receptor 0 0 0.412612613 kegg kegg NA NA no no no no no no Glycerolipid metabolism Viral protein interaction with cytokine and cytokine receptor 0 0 -0.473873874 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Viral protein interaction with cytokine and cytokine receptor -0.56 0 -0.576833977 kegg kegg NA NA no no up no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Viral protein interaction with cytokine and cytokine receptor 0 -0.457509881 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Viral protein interaction with cytokine and cytokine receptor 0 -0.540513834 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Viral protein interaction with cytokine and cytokine receptor 0 0.41798419 0 kegg kegg NA NA no no no no no no Histidine metabolism Viral protein interaction with cytokine and cytokine receptor -0.597391304 0 0 kegg kegg NA NA no no no no no no Homologous recombination Viral protein interaction with cytokine and cytokine receptor 0 -0.562252964 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Viral protein interaction with cytokine and cytokine receptor -0.455652174 -0.522727273 -0.564478764 kegg kegg NA NA no no no no no no Lysine degradation Viral protein interaction with cytokine and cytokine receptor 0 -0.778656126 -0.583011583 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Viral protein interaction with cytokine and cytokine receptor 0 -0.701581028 -0.444530245 kegg kegg NA NA no no no no no no MAPK signaling pathway Viral protein interaction with cytokine and cytokine receptor 0 0 -0.499099099 kegg kegg NA NA no no no no no no mRNA surveillance pathway Viral protein interaction with cytokine and cytokine receptor 0 -0.670948617 -0.450707851 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Viral protein interaction with cytokine and cytokine receptor 0 -0.41798419 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Viral protein interaction with cytokine and cytokine receptor 0 -0.476284585 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Viral protein interaction with cytokine and cytokine receptor 0 0.416007905 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Viral protein interaction with cytokine and cytokine receptor 0 0.48715415 0 kegg kegg NA NA no no no no no no One carbon pool by folate Viral protein interaction with cytokine and cytokine receptor -0.429565217 0 0 kegg kegg NA NA no no no no no no Other glycan degradation Viral protein interaction with cytokine and cytokine receptor 0 -0.553359684 -0.469498069 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Viral protein interaction with cytokine and cytokine receptor 0 -0.621541502 -0.575289575 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Viral protein interaction with cytokine and cytokine receptor 0 0.43972332 0 kegg kegg NA NA no no dn no no no Pentose and glucuronate interconversions Viral protein interaction with cytokine and cytokine receptor 0 -0.443675889 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Viral protein interaction with cytokine and cytokine receptor 0 0.600790514 0 kegg kegg NA NA no no no no no no Platinum drug resistance Viral protein interaction with cytokine and cytokine receptor 0 -0.481225296 -0.428056628 kegg kegg NA NA no no no no no no Pyrimidine metabolism Viral protein interaction with cytokine and cytokine receptor -0.454782609 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Viral protein interaction with cytokine and cytokine receptor 0 0 0.564993565 kegg kegg NA NA no no no no no no Ras signaling pathway Viral protein interaction with cytokine and cytokine receptor 0.539130435 0 0 yes kegg kegg NA NA no up up no no no Ribosome biogenesis in eukaryotes Viral protein interaction with cytokine and cytokine receptor 0 -0.633399209 0 kegg kegg NA NA no no no no no no RNA degradation Viral protein interaction with cytokine and cytokine receptor 0 -0.565217391 -0.451480051 kegg kegg NA NA no no no no no no RNA polymerase Viral protein interaction with cytokine and cytokine receptor 0 -0.59486166 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Viral protein interaction with cytokine and cytokine receptor -0.52173913 -0.586956522 -0.534105534 kegg kegg NA NA no no no no no no Spliceosome Viral protein interaction with cytokine and cytokine receptor 0 -0.669960474 -0.494465894 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Viral protein interaction with cytokine and cytokine receptor -0.406086957 0 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Viral protein interaction with cytokine and cytokine receptor -0.43826087 0 -0.527155727 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Viral protein interaction with cytokine and cytokine receptor 0 -0.429841897 0 kegg kegg NA NA no no no no no no Thiamine metabolism Viral protein interaction with cytokine and cytokine receptor -0.484347826 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Viral protein interaction with cytokine and cytokine receptor -0.58173913 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Viral protein interaction with cytokine and cytokine receptor -0.454782609 0 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Viral protein interaction with cytokine and cytokine receptor 0 -0.541501976 0 kegg kegg NA NA no no no no no no 14:0/18:2-PC+blood Visfatin 0 -0.526960784 0 serum_phospholipids DM-assocaited hormones 0.102 0.0229 no up no dn no up 15-HETE+blood Visfatin 0 0 0.427849393 serum_ARA DM-assocaited hormones 0.819 0.0229 no no no dn no up 16:0/16:1-PC+blood Visfatin 0 -0.772058824 0 serum_phospholipids DM-assocaited hormones 0.00283 0.0229 up up no dn no up 16:0/18:2-PI+blood Visfatin 0 -0.683823529 0 serum_phospholipids DM-assocaited hormones 0.269 0.0229 no no no dn no up 16:0/20:4-PI+blood Visfatin 0 -0.490196078 0 serum_phospholipids DM-assocaited hormones 0.558 0.0229 no no no dn no up 16:0/22:6-PC+blood Visfatin 0 0.482843137 0 serum_phospholipids DM-assocaited hormones 4.53E-05 0.0229 no up up dn no up 16:1/16:0-PC+blood Visfatin 0 0.482843137 0 serum_phospholipids DM-assocaited hormones 0.0215 0.0229 no up up dn no up 18:0-LPC+blood Visfatin 0 0 0.423478261 serum_phospholipids DM-assocaited hormones 0.554 0.0229 no no no dn no up 18:0/18:1-PC+blood Visfatin 0 -0.514705882 0 serum_phospholipids DM-assocaited hormones 0.393 0.0229 no no no dn no up 18:0/18:1-PE+blood Visfatin 0 -0.659313725 0 serum_phospholipids DM-assocaited hormones 0.00716 0.0229 up up no dn no up 18:0/20:3-PC+blood Visfatin 0 -0.583333333 0 serum_phospholipids DM-assocaited hormones 0.0682 0.0229 no up no dn no up 18:0/20:4-PI+blood Visfatin 0.521155831 0 0 serum_phospholipids DM-assocaited hormones 0.167 0.0229 no no no dn no up 18:0/20:5-PC+blood Visfatin 0 0.588235294 0 serum_phospholipids DM-assocaited hormones 0.17 0.0229 no no no dn no up 18:1-LPC+blood Visfatin 0 0.490196078 0 serum_phospholipids DM-assocaited hormones 0.179 0.0229 no no no dn no up 18:1/18:1-PE+blood Visfatin 0 -0.539215686 0 serum_phospholipids DM-assocaited hormones 1.03E-05 0.0229 up up no dn no up 18:1/18:2-PG+blood Visfatin 0 0 0.445217391 serum_phospholipids DM-assocaited hormones 5.58E-07 0.0229 no up up dn no up 18:1/20:4-PC+blood Visfatin 0 0.522058824 0 serum_phospholipids DM-assocaited hormones 0.582 0.0229 no no no dn no up 18:3n3+blood Visfatin 0 0.524509804 0 serum_fattyacid DM-assocaited hormones 0.291 0.0229 no no no dn no up 20:2/18:0-PC+blood Visfatin 0 -0.566176471 0 serum_phospholipids DM-assocaited hormones 0.0427 0.0229 no up no dn no up 20:3n6+blood Visfatin 0 -0.519607843 0 serum_fattyacid DM-assocaited hormones 0.0884 0.0229 up no no dn no up 20:5/18:0-PC+blood Visfatin 0 0.529411765 0 serum_phospholipids DM-assocaited hormones 3.97E-06 0.0229 no up up dn no up 4-hydroxybenzoic acid+stool Visfatin 0 0 -0.455844156 stool_cometabolism DM-assocaited hormones 0.0536 0.0229 no dn no dn no up 8-HETE+blood Visfatin 0 0.742647059 0 serum_ARA DM-assocaited hormones 0.741 0.0229 no no no dn no up AA+blood Visfatin 0 0.56372549 0 serum_ARA DM-assocaited hormones 0.212 0.0229 no no no dn no up ACA+stool Visfatin -0.52935619 0 0 stool_bileacids DM-assocaited hormones 0.417 0.0229 no no no dn no up Adrenergic signaling in cardiomyocytes Visfatin -0.480519481 0 0 kegg DM-assocaited hormones NA 0.0229 no no up dn no up Aldosterone synthesis and secretion Visfatin -0.470355731 0 0 kegg DM-assocaited hormones NA 0.0229 no up up dn no up Allograft rejection Visfatin 0 0 -0.503008021 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Amphetamine addiction Visfatin -0.463579898 0 0 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Arginine and proline metabolism Visfatin 0.465838509 0 0 kegg DM-assocaited hormones NA 0.0229 no up no dn no up Autoimmune thyroid disease Visfatin 0 0 -0.503008021 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Axon guidance Visfatin 0 -0.414031621 0 kegg DM-assocaited hormones NA 0.0229 no up up dn no up Betaine+blood Visfatin 0 0.546568627 0 serum_choline DM-assocaited hormones 0.857 0.0229 no no no dn no up Blautia Visfatin 0 0.432173913 0 acetate-producing Genus DM-assocaited hormones 1.36E-05 0.0229 up dn dn dn no up C-peptide Visfatin -0.59486166 0 -0.571428571 DM-assocaited hormones DM-assocaited hormones 0.228 0.0229 no no no dn no up Cell adhesion molecules Visfatin 0 0 -0.462566845 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Cellular senescence Visfatin 0 0 -0.495320856 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Chemical carcinogenesis - receptor activation Visfatin -0.454545455 0 0.527740642 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Circadian entrainment Visfatin -0.427442123 0 0.420120321 kegg DM-assocaited hormones NA 0.0229 no up up dn no up Coronavirus disease - COVID-19 Visfatin 0 -0.414031621 0 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Cushing syndrome Visfatin -0.444381705 0 0 kegg DM-assocaited hormones NA 0.0229 no no up dn no up d18:1-18:0-SM+blood Visfatin 0 0.544117647 0 serum_phospholipids DM-assocaited hormones 0.97 0.0229 no no no dn no up d18:1-20:1-SM+blood Visfatin 0 0.553921569 0 serum_phospholipids DM-assocaited hormones 0.0992 0.0229 no no no dn no up d18:1-24:1-SM+blood Visfatin 0.486068111 0 0 serum_phospholipids DM-assocaited hormones 0.0123 0.0229 no dn dn dn no up DHA+blood Visfatin 0 0.526960784 0 serum_ARA DM-assocaited hormones 0.872 0.0229 no no no dn no up Dopaminergic synapse Visfatin -0.489553924 0 0 kegg DM-assocaited hormones NA 0.0229 no up no dn no up DPA+blood Visfatin 0 0.490196078 0 serum_ARA DM-assocaited hormones 0.519 0.0229 no no no dn no up EGFR tyrosine kinase inhibitor resistance Visfatin 0 -0.416007905 0 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Endocrine and other factor-regulated calcium reabsorption Visfatin 0 0 0.466911765 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Endocrine resistance Visfatin 0 0 0.461564171 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Endocytosis Visfatin 0 0 -0.479612299 kegg DM-assocaited hormones NA 0.0229 no no no dn no up EPA+blood Visfatin 0 0.531862745 0 serum_ARA DM-assocaited hormones 0.212 0.0229 no no no dn no up Ethanolamine+blood Visfatin 0 0.487745098 0 serum_aminoacids DM-assocaited hormones 0.122 0.0229 up no no dn no up Gap junction Visfatin -0.532467532 0 0 kegg DM-assocaited hormones NA 0.0229 no no no dn no up GCDCA+stool Visfatin -0.629411765 0 0 yes stool_bileacids DM-assocaited hormones 0.0471 0.0229 no dn no dn no up GLCA+blood Visfatin 0 0 0.409776153 serum_bileacids DM-assocaited hormones 0.319 0.0229 no no no dn no up GLP-1 Visfatin 0 0 -0.408963585 DM-assocaited hormones DM-assocaited hormones 0.256 0.0229 no no no dn no up Glucagon Visfatin 0 0 -0.421848739 DM-assocaited hormones DM-assocaited hormones 0.0283 0.0229 no no up dn no up Glycine+blood Visfatin 0 0.529411765 0 serum_aminoacids DM-assocaited hormones 0.00408 0.0229 dn no up dn no up Graft-versus-host disease Visfatin 0 0 -0.503342246 kegg DM-assocaited hormones NA 0.0229 no no no dn no up GUDCA+blood Visfatin 0 -0.514705882 0 serum_bileacids DM-assocaited hormones 0.0766 0.0229 no no dn dn no up HCA+blood Visfatin 0 -0.492291066 0 serum_bileacids DM-assocaited hormones 0.544 0.0229 no no no dn no up HIF-1 signaling pathway Visfatin 0 -0.433794466 0 kegg DM-assocaited hormones NA 0.0229 no no no dn no up IL-8 Visfatin 0 0 0.413245758 serum_cytokines DM-assocaited hormones 0.579 0.0229 no no no dn no up Indole-3-Acetic acid+urine Visfatin 0 0 0.517786561 urine_cometabolism DM-assocaited hormones 0.657 0.0229 no no no dn no up Inflammatory mediator regulation of TRP channels Visfatin -0.482778091 0 0.409759358 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Insulin Visfatin -0.641304348 0 0 yes DM-assocaited hormones DM-assocaited hormones 0.00058 0.0229 up up no dn no up Intestinal immune network for IgA production Visfatin 0 -0.524703557 0 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Kaposi sarcoma-associated herpesvirus infection Visfatin -0.429700734 0 0 kegg DM-assocaited hormones NA 0.0229 no no dn dn no up L-Asparagine+blood Visfatin 0 0.568627451 0 serum_aminoacids DM-assocaited hormones 0.784 0.0229 no no no dn no up L-Glutamine+blood Visfatin 0 0.490196078 0 serum_aminoacids DM-assocaited hormones 0.639 0.0229 no no no dn no up L-Phenylalanine+urine Visfatin 0 -0.489473684 0 urine_cometabolism DM-assocaited hormones 0.0908 0.0229 no up no dn no up L-Tryptophan+urine Visfatin 0 -0.524561404 0 urine_cometabolism DM-assocaited hormones 0.226 0.0229 no no no dn no up Leptin Visfatin 0 -0.408695652 -0.411484594 DM-assocaited hormones DM-assocaited hormones 0.706 0.0229 no no no dn no up Morphine addiction Visfatin -0.45567476 0 0 kegg DM-assocaited hormones NA 0.0229 no up up dn no up mTOR signaling pathway Visfatin 0 -0.429841897 0 kegg DM-assocaited hormones NA 0.0229 no no no dn no up MUFA%+blood Visfatin 0 0.593137255 0 serum_fattyacid DM-assocaited hormones 0.00142 0.0229 up no dn dn no up Natural killer cell mediated cytotoxicity Visfatin 0 0 -0.49565508 kegg DM-assocaited hormones NA 0.0229 no no no dn no up PAI-1 Visfatin -0.539525692 0 0 yes DM-assocaited hormones DM-assocaited hormones 5.10E-05 0.0229 up up up dn no up Pancreatic secretion Visfatin -0.495200452 0 0 kegg DM-assocaited hormones NA 0.0229 no no no dn no up "Parathyroid hormone synthesis, secretion and action" Visfatin -0.435347261 0 0.454545455 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Peroxisome Visfatin 0.612648221 0 0 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Phenylacetyl L-GlutaMine+urine Visfatin 0 0.584210526 0 urine_cometabolism DM-assocaited hormones 0.0909 0.0229 up no no dn no up PUFA%+blood Visfatin 0 0.551470588 0 serum_fattyacid DM-assocaited hormones 0.0013 0.0229 dn no up dn no up Regulation of lipolysis in adipocytes Visfatin 0 0 0.451871658 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Renin secretion Visfatin -0.464709204 0 0 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Resistin Visfatin 0.562252964 0.448695652 0.590196078 DM-assocaited hormones DM-assocaited hormones 0.156 0.0229 no no no dn no up Ruminococcus Visfatin -0.494071146 0 0 acetate-producing Genus DM-assocaited hormones 0.335 0.0229 no no no dn no up Serine+blood Visfatin 0 0.610294118 0 serum_aminoacids DM-assocaited hormones 0.942 0.0229 no no no dn no up Systemic lupus erythematosus Visfatin 0.590062112 0 0 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Taurine+blood Visfatin 0 0.644607843 0 serum_aminoacids DM-assocaited hormones 0.857 0.0229 no no no dn no up Thyroid hormone synthesis Visfatin -0.454545455 0 0 kegg DM-assocaited hormones NA 0.0229 no no no dn no up TMAO+blood Visfatin 0 0.742647059 0 serum_choline DM-assocaited hormones 0.00706 0.0229 up up no dn no up Tuberculosis Visfatin 0.465838509 0 0 kegg DM-assocaited hormones NA 0.0229 no no dn dn no up TXB2+blood Visfatin 0 0.668914578 0 yes serum_ARA DM-assocaited hormones 0.0644 0.0229 dn no no dn no up Type I diabetes mellitus Visfatin 0 0 -0.509692513 kegg DM-assocaited hormones NA 0.0229 no no no dn no up UFA%+blood Visfatin 0 0.507352941 0 serum_fattyacid DM-assocaited hormones 0.0236 0.0229 no dn no dn no up Vascular smooth muscle contraction Visfatin 0 0 0.409759358 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Viral myocarditis Visfatin 0 0 -0.421791444 kegg DM-assocaited hormones NA 0.0229 no no no dn no up Viral protein interaction with cytokine and cytokine receptor Visfatin -0.459062676 0 0 kegg DM-assocaited hormones NA 0.0229 no no no dn no up 2-Oxocarboxylic acid metabolism Vitamin digestion and absorption -0.613043478 0 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Vitamin digestion and absorption 0.429565217 0 0 kegg kegg NA NA no no up no no no Aldosterone synthesis and secretion Vitamin digestion and absorption 0.450434783 0 0 kegg kegg NA NA no up up no no no alpha-Linolenic acid metabolism Vitamin digestion and absorption -0.600869565 0.471343874 0.414671815 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Vitamin digestion and absorption -0.624347826 0.561264822 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Vitamin digestion and absorption -0.473043478 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Vitamin digestion and absorption 0 0 -0.577348777 kegg kegg NA NA no no no no no no Antifolate resistance Vitamin digestion and absorption 0 0 0.593822394 kegg kegg NA NA no no no no no no Antigen processing and presentation Vitamin digestion and absorption -0.526956522 0 -0.418790219 kegg kegg NA NA no no no no no no Apoptosis Vitamin digestion and absorption -0.435652174 0 0 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Vitamin digestion and absorption 0 0 0.51994852 kegg kegg NA NA no no no no no no Axon guidance Vitamin digestion and absorption 0 -0.59486166 0 kegg kegg NA NA no up up no no no beta-Alanine metabolism Vitamin digestion and absorption -0.597391304 0 0 kegg kegg NA NA no no no no no no Bile secretion Vitamin digestion and absorption 0 0 -0.506821107 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Vitamin digestion and absorption -0.744347826 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Vitamin digestion and absorption 0 0 -0.512226512 kegg kegg NA NA no no no no no no Butanoate metabolism Vitamin digestion and absorption -0.555652174 0 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Vitamin digestion and absorption 0.530434783 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway Vitamin digestion and absorption 0.567826087 0 0 yes kegg kegg NA NA no up up no no no Carbohydrate digestion and absorption Vitamin digestion and absorption 0 0 0.582239382 kegg kegg NA NA no no no no no no Carbon metabolism Vitamin digestion and absorption -0.782608696 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction Vitamin digestion and absorption 0.589565217 0 0 kegg kegg NA NA no no up no no no Cell adhesion molecules Vitamin digestion and absorption -0.672173913 0 0 kegg kegg NA NA no no no no no no Cellular senescence Vitamin digestion and absorption -0.530434783 0 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Vitamin digestion and absorption 0.432173913 0 0.401029601 kegg kegg NA NA no no no no no no Circadian entrainment Vitamin digestion and absorption 0 0 -0.429343629 kegg kegg NA NA no up up no no no Circadian rhythm Vitamin digestion and absorption 0.509565217 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Vitamin digestion and absorption -0.653913043 0 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Vitamin digestion and absorption 0 -0.477272727 0 kegg kegg NA NA no no no no no no Dopaminergic synapse Vitamin digestion and absorption 0.46173913 0 0 kegg kegg NA NA no up no no no no Drug metabolism - cytochrome P450 Vitamin digestion and absorption -0.492173913 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Vitamin digestion and absorption -0.636521739 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Vitamin digestion and absorption 0.523478261 0 0 kegg kegg NA NA no no no no no no Endocytosis Vitamin digestion and absorption -0.566086957 0 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Vitamin digestion and absorption 0 0 -0.51016731 kegg kegg NA NA no no no no no no Ether lipid metabolism Vitamin digestion and absorption 0.546956522 0 0 kegg kegg NA NA no no no no no no Fat digestion and absorption Vitamin digestion and absorption 0 0 0.411325611 yes kegg kegg NA NA no up up no no no Fatty acid degradation Vitamin digestion and absorption 0 0.429841897 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Vitamin digestion and absorption 0 0.438735178 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Vitamin digestion and absorption 0.611304348 0 0.540797941 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Vitamin digestion and absorption -0.70173913 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Vitamin digestion and absorption -0.511304348 0.510869565 0 kegg kegg NA NA no no no no no no Gap junction Vitamin digestion and absorption 0 0 -0.568339768 kegg kegg NA NA no no no no no no Glutamatergic synapse Vitamin digestion and absorption 0 0 -0.456885457 kegg kegg NA NA no up up no no no Glutathione metabolism Vitamin digestion and absorption 0 0 -0.491119691 kegg kegg NA NA no no no no no no Glycerolipid metabolism Vitamin digestion and absorption 0 0.459486166 0.63011583 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Vitamin digestion and absorption 0.489565217 0.419960474 0.587644788 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Vitamin digestion and absorption 0 0 -0.524324324 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Vitamin digestion and absorption -0.783478261 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Vitamin digestion and absorption 0 0 0.608494208 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Vitamin digestion and absorption -0.48 0 0.487773488 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Vitamin digestion and absorption 0.54173913 -0.427865613 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Vitamin digestion and absorption 0 0 0.581724582 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - lacto and neolacto series Vitamin digestion and absorption 0.589565217 0 0 kegg kegg NA NA no no no no no no GnRH secretion Vitamin digestion and absorption 0.536521739 0 0.574517375 kegg kegg NA NA no up up no no no "Growth hormone synthesis, secretion and action" Vitamin digestion and absorption 0.476521739 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Vitamin digestion and absorption 0.696521739 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Vitamin digestion and absorption 0 -0.434782609 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Vitamin digestion and absorption 0 0 0.698326898 kegg kegg NA NA no no no no no no Histidine metabolism Vitamin digestion and absorption 0 0.593873518 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Vitamin digestion and absorption 0 0 0.528700129 kegg kegg NA NA no no no no no no Insulin resistance Vitamin digestion and absorption 0.465217391 0 0.400772201 kegg kegg NA NA no no no no no no Long-term depression Vitamin digestion and absorption 0.462608696 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Vitamin digestion and absorption 0 0 -0.465122265 kegg kegg NA NA no no no no no no Lysine degradation Vitamin digestion and absorption 0 0 0.5001287 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Vitamin digestion and absorption 0.470434783 0 0.445559846 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Vitamin digestion and absorption 0.563478261 0 0.441698842 kegg kegg NA NA no up no no no no Metabolism of xenobiotics by cytochrome P450 Vitamin digestion and absorption -0.52 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Vitamin digestion and absorption 0 0 -0.442471042 kegg kegg NA NA no no no no no no mRNA surveillance pathway Vitamin digestion and absorption 0.682608696 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Vitamin digestion and absorption 0 -0.443675889 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Vitamin digestion and absorption -0.479130435 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Vitamin digestion and absorption -0.665217391 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Vitamin digestion and absorption 0.650434783 -0.509881423 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Vitamin digestion and absorption -0.609565217 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Vitamin digestion and absorption 0.786086957 0 0.702960103 kegg kegg NA NA no no no no no no Other glycan degradation Vitamin digestion and absorption -0.437391304 0 0.604118404 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Vitamin digestion and absorption 0 0 0.416988417 kegg kegg NA NA no no no no no no Ovarian steroidogenesis Vitamin digestion and absorption 0 0 -0.421364221 kegg kegg NA NA no up up no no no Oxidative phosphorylation Vitamin digestion and absorption 0.625217391 0 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Vitamin digestion and absorption 0 0.414031621 0 kegg kegg NA NA no no dn no no no Pentose phosphate pathway Vitamin digestion and absorption -0.447826087 0 0 kegg kegg NA NA no no no no no no Phagosome Vitamin digestion and absorption -0.552173913 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Vitamin digestion and absorption 0.596521739 0 0.471814672 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway Vitamin digestion and absorption 0 -0.548418972 0 yes kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism Vitamin digestion and absorption 0 0 -0.543114543 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Vitamin digestion and absorption 0 0 0.561904762 kegg kegg NA NA no no no no no no Prolactin signaling pathway Vitamin digestion and absorption 0.490434783 0 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Vitamin digestion and absorption 0 0 -0.424710425 kegg kegg NA NA no no no no no no Pyrimidine metabolism Vitamin digestion and absorption -0.479130435 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Vitamin digestion and absorption -0.443478261 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Vitamin digestion and absorption 0 0 -0.403346203 kegg kegg NA NA no no no no no no Renin secretion Vitamin digestion and absorption 0 0 -0.483140283 kegg kegg NA NA no no no no no no Retinol metabolism Vitamin digestion and absorption -0.47826087 0.481225296 0 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling Vitamin digestion and absorption 0.445217391 0 0 kegg kegg NA NA no no up no no no Ribosome Vitamin digestion and absorption 0.475652174 0 0 kegg kegg NA NA no no no no no no RNA degradation Vitamin digestion and absorption 0.62173913 0 0 kegg kegg NA NA no no no no no no RNA transport Vitamin digestion and absorption -0.448695652 -0.427865613 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Vitamin digestion and absorption 0 0.469367589 0 kegg kegg NA NA no no no no no no Serotonergic synapse Vitamin digestion and absorption 0 0 -0.412612613 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Vitamin digestion and absorption 0.542608696 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Vitamin digestion and absorption 0 0 0.48030888 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Vitamin digestion and absorption 0.464347826 0 0.495495495 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Vitamin digestion and absorption 0 0.520750988 0.43011583 kegg kegg NA NA no no no no no no Steroid biosynthesis Vitamin digestion and absorption 0.406956522 0.419960474 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Vitamin digestion and absorption 0 0.457509881 0 kegg kegg NA NA no no no no no no Sulfur metabolism Vitamin digestion and absorption -0.467826087 0 -0.447104247 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Vitamin digestion and absorption 0 0 0.421364221 kegg kegg NA NA no up up no no no Taste transduction Vitamin digestion and absorption 0 0.418972332 0.512998713 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism Vitamin digestion and absorption 0.428695652 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Vitamin digestion and absorption 0.58 0 0 kegg kegg NA NA no no no no no no Thermogenesis Vitamin digestion and absorption 0.635652174 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Vitamin digestion and absorption 0 0 -0.498326898 kegg kegg NA NA no no no no no no Tryptophan metabolism Vitamin digestion and absorption -0.426086957 0 0 kegg kegg NA NA no up no no no no Type I diabetes mellitus Vitamin digestion and absorption -0.532173913 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Vitamin digestion and absorption 0 0 0.515830116 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Vitamin digestion and absorption 0 0 -0.43963964 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Vitamin digestion and absorption 0.446086957 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Vitamin digestion and absorption 0.513043478 0 0.50965251 kegg kegg NA NA no no no no no no Wnt signaling pathway Vitamin digestion and absorption 0.651304348 0 0.492921493 kegg kegg NA NA no no no no no no 16:0/16:1-PC+blood waistline+clinic 0 -0.578571429 0 serum_phospholipids clinic 0.00283 0.00351 up up no up up no 16:0/18:2-PI+blood waistline+clinic 0 -0.635714286 0 serum_phospholipids clinic 0.269 0.00351 no no no up up no 16:0/22:6-PC+blood waistline+clinic 0.488132095 0 0 serum_phospholipids clinic 4.53E-05 0.00351 no up up up up no 18:0/18:1-PE+blood waistline+clinic 0 -0.6 0 serum_phospholipids clinic 0.00716 0.00351 up up no up up no 18:0/20:3-PC+blood waistline+clinic -0.494324045 0 -0.453076923 serum_phospholipids clinic 0.0682 0.00351 no up no up up no 18:0/20:3-PI+blood waistline+clinic 0 -0.532142857 0 serum_phospholipids clinic 0.377 0.00351 no no no up up no 18:0/20:4-PC+blood waistline+clinic 0 0.525 0 serum_phospholipids clinic 0.454 0.00351 no no no up up no 18:0/20:5-PC+blood waistline+clinic 0 0.6 0 serum_phospholipids clinic 0.17 0.00351 no no no up up no 18:1/18:1-PE+blood waistline+clinic 0 -0.7 0 serum_phospholipids clinic 1.03E-05 0.00351 up up no up up no 18:2-LPE+blood waistline+clinic 0 0 0.402307692 serum_phospholipids clinic 0.112 0.00351 no no no up up no 18:2n6c+blood waistline+clinic 0 0 -0.402307692 serum_fattyacid clinic 0.15 0.00351 no no no up up no 18:3n6+blood waistline+clinic -0.801857585 0 0 serum_fattyacid clinic 0.0463 0.00351 up no dn up up no 20:2/18:0-PC+blood waistline+clinic -0.500515996 0 -0.467692308 serum_phospholipids clinic 0.0427 0.00351 no up no up up no 20:3n6+blood waistline+clinic -0.659442724 -0.557142857 0 serum_fattyacid clinic 0.0884 0.00351 up no no up up no 20:4-LPC+blood waistline+clinic 0 0.582142857 0 serum_phospholipids clinic 0.949 0.00351 no no no up up no 20:4n6+blood waistline+clinic 0 0.603571429 0 serum_fattyacid clinic 0.133 0.00351 no no no up up no 4-hydroxybenzoic acid+stool waistline+clinic 0 0 0.448898927 stool_cometabolism clinic 0.0536 0.00351 no dn no up up no 8-HETE+blood waistline+clinic 0 0.564285714 0 serum_ARA clinic 0.741 0.00351 no no no up up no AA+blood waistline+clinic 0 0.589285714 0.456153846 serum_ARA clinic 0.212 0.00351 no no no up up no Akkermansia waistline+clinic 0 0 -0.485103951 acetate-producing Genus clinic 0.23 0.00351 no no no up up no Allograft rejection waistline+clinic -0.516657256 0 0 kegg clinic NA 0.00351 no no no up up no Autoimmune thyroid disease waistline+clinic -0.516657256 0 0 kegg clinic NA 0.00351 no no no up up no Cell adhesion molecules waistline+clinic -0.446640316 0 0 kegg clinic NA 0.00351 no no no up up no Cellular senescence waistline+clinic -0.509881423 0 0 kegg clinic NA 0.00351 no no no up up no Circadian entrainment waistline+clinic 0 -0.437662338 0 kegg clinic NA 0.00351 no up up up up no Creatinine+blood waistline+clinic 0.473684211 0 0 serum_choline clinic 0.437 0.00351 no no no up up no Cystine+blood waistline+clinic 0 0 0.468461538 yes serum_aminoacids clinic 0.00028 0.00351 up up no up up no Dilated cardiomyopathy waistline+clinic 0 -0.454545455 0 kegg clinic NA 0.00351 no up up up up no Endocytosis waistline+clinic -0.431959345 0 0 kegg clinic NA 0.00351 no no no up up no Eotaxin waistline+clinic 0 0.570175439 0 serum_cytokines clinic 0.393 0.00351 no no no up up no EPA+blood waistline+clinic 0 0.535714286 0 serum_ARA clinic 0.212 0.00351 no no no up up no Gastric acid secretion waistline+clinic 0 -0.438961039 0 kegg clinic NA 0.00351 no no no up up no Graft-versus-host disease waistline+clinic -0.511010728 0 0 kegg clinic NA 0.00351 no no no up up no GUDCA+blood waistline+clinic 0 0 0.500769231 serum_bileacids clinic 0.0766 0.00351 no no dn up up no Hippo signaling pathway waistline+clinic 0 -0.461038961 0 kegg clinic NA 0.00351 no no no up up no Human papillomavirus infection waistline+clinic -0.459062676 0 0 kegg clinic NA 0.00351 no no no up up no Inflammatory mediator regulation of TRP channels waistline+clinic 0 -0.441558442 0 kegg clinic NA 0.00351 no no no up up no L-Phenylalanine+blood waistline+clinic 0.494324045 0 0 yes serum_aminoacids clinic 0.0103 0.00351 up up no up up no L-Proline+blood waistline+clinic 0.51496388 -0.678571429 0 yes serum_aminoacids clinic 0.00265 0.00351 up up no up up no L-Tryptophan+stool waistline+clinic 0 0 -0.431959345 stool_cometabolism clinic 0.557 0.00351 no no no up up no MAPK signaling pathway waistline+clinic 0.445511011 0.449350649 0 kegg clinic NA 0.00351 no no no up up no Measles waistline+clinic 0 0.606493506 0 kegg clinic NA 0.00351 no no no up up no n6+blood waistline+clinic 0 0 -0.46 serum_fattyacid clinic 0.153 0.00351 no no no up up no Natural killer cell mediated cytotoxicity waistline+clinic -0.429700734 0 0 kegg clinic NA 0.00351 no no no up up no nutriCA+stool waistline+clinic 0 0 0.424054207 stool_bileacids clinic 0.481 0.00351 no no no up up no Oscillospira waistline+clinic 0 0.497459063 0 LPS-producing Genus clinic 0.62 0.00351 no no no up up no Paraprevotella waistline+clinic 0 -0.559666574 0 Genus clinic 0.118 0.00351 no no no up up no Phenylacetic acid+stool waistline+clinic 0 0 -0.522303783 stool_cometabolism clinic 0.785 0.00351 no no no up up no Platelet activation waistline+clinic 0 -0.451948052 0 kegg clinic NA 0.00351 no no no up up no PUFA+blood waistline+clinic 0 0 -0.574615385 serum_fattyacid clinic 0.212 0.00351 no no no up up no RANTES waistline+clinic 0 0 0.446305419 yes serum_cytokines clinic 0.0757 0.00351 no no up up up no Rap1 signaling pathway waistline+clinic 0 -0.442857143 0 kegg clinic NA 0.00351 no no no up up no Renin secretion waistline+clinic 0 -0.437662338 0 kegg clinic NA 0.00351 no no no up up no Roseburia waistline+clinic 0 -0.438859097 0 butyrate-producing Genus clinic 0.495 0.00351 no no no up up no Serine+blood waistline+clinic 0.529411765 0 0 serum_aminoacids clinic 0.942 0.00351 no no no up up no TCA+stool waistline+clinic 0 -0.633259046 0 stool_bileacids clinic 0.458 0.00351 no no no up up no Th17 cell differentiation waistline+clinic 0 0.479220779 0 kegg clinic NA 0.00351 no no no up up no TMAO+blood waistline+clinic 0 0 -0.498461538 serum_choline clinic 0.00706 0.00351 up up no up up no ToFA+blood waistline+clinic 0 0 -0.415384615 serum_fattyacid clinic 0.0307 0.00351 up no dn up up no TXB2+blood waistline+clinic 0 0.56619328 0 yes serum_ARA clinic 0.0644 0.00351 dn no no up up no Type I diabetes mellitus waistline+clinic -0.516657256 0 0 kegg clinic NA 0.00351 no no no up up no UDCA+stool waistline+clinic 0 0 0.444381705 stool_bileacids clinic 0.266 0.00351 no no no up up no UFA+blood waistline+clinic 0 0 -0.42 serum_fattyacid clinic 0.0444 0.00351 up no dn up up no Vascular smooth muscle contraction waistline+clinic 0 -0.451948052 0 kegg clinic NA 0.00351 no no no up up no Vibrio cholerae infection waistline+clinic 0 -0.438961039 0 kegg clinic NA 0.00351 no no no up up no Viral carcinogenesis waistline+clinic -0.480519481 0 0 kegg clinic NA 0.00351 no no no up up no Viral myocarditis waistline+clinic -0.532467532 0 0 kegg clinic NA 0.00351 no no no up up no "12,13-EPOME+blood" Weight+clinic 0 0 0.406419082 serum_ARA clinic 0.901 0.00971 no no no no up no 16:0/18:1-PC+blood Weight+clinic 0.502579979 0 0 serum_phospholipids clinic 6.15E-07 0.00971 up up up no up no 16:1+blood Weight+clinic 0 -0.721428571 0.426153846 yes serum_fattyacid clinic 0.0186 0.00971 no no dn no up no 18:0/16:0-PC+blood Weight+clinic 0.547987616 0 0 serum_phospholipids clinic 9.64E-07 0.00971 up up up no up no 18:0/20:2-PC+blood Weight+clinic 0 0 -0.420769231 serum_phospholipids clinic 0.733 0.00971 no no no no up no 18:0/20:3-PC+blood Weight+clinic 0 0 -0.461538462 serum_phospholipids clinic 0.0682 0.00971 no up no no up no 18:1/18:2-PI+blood Weight+clinic 0 0 -0.434615385 serum_phospholipids clinic 0.0164 0.00971 dn no up no up no 18:1/20:3-PC+blood Weight+clinic 0 0 -0.443076923 serum_phospholipids clinic 0.00872 0.00971 no up up no up no 20:2/18:0-PC+blood Weight+clinic 0 0 -0.470769231 serum_phospholipids clinic 0.0427 0.00971 no up no no up no 20:4-LPA+blood Weight+clinic 0 0.557142857 0 serum_phospholipids clinic 0.398 0.00971 no no no no up no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Weight+clinic -0.479876161 0 0 urine_cometabolism clinic 0.0125 0.00971 up up no no up no 4-Hydroxyphenylacetic acid+urine Weight+clinic 0 0 -0.420769231 urine_cometabolism clinic 0.0321 0.00971 up up no no up no 9-HODE+blood Weight+clinic 0 0 0.497692308 serum_ARA clinic 0.297 0.00971 no no no no up no "9,10-EPOME+blood" Weight+clinic 0 -0.562727629 0.400396415 serum_ARA clinic 0.801 0.00971 no no no no up no Alzheimer disease Weight+clinic 0 0 0.402521008 kegg clinic NA 0.00971 no no no no up no Axon guidance Weight+clinic -0.601355167 0 0 kegg clinic NA 0.00971 no up up no up no B cell receptor signaling pathway Weight+clinic -0.5256917 0 0 kegg clinic NA 0.00971 no no no no up no CA+stool Weight+clinic 0 0.745454545 0 stool_bileacids clinic 0.827 0.00971 no no no no up no Central carbon metabolism in cancer Weight+clinic 0 0.574025974 0 kegg clinic NA 0.00971 no no no no up no Cholinergic synapse Weight+clinic 0 0 0.482352941 kegg clinic NA 0.00971 no no no no up no Chronic myeloid leukemia Weight+clinic -0.473743648 0 0 kegg clinic NA 0.00971 no no no no up no Circadian entrainment Weight+clinic 0.507622812 -0.437662338 0 kegg clinic NA 0.00971 no up up no up no d18:1-14:0-SM+blood Weight+clinic -0.521155831 0 0 serum_phospholipids clinic 0.94 0.00971 no no no no up no DCA+stool Weight+clinic 0 -0.645454545 0 stool_bileacids clinic 0.195 0.00971 no no no no up no Dilated cardiomyopathy Weight+clinic 0.425183512 0 0 kegg clinic NA 0.00971 no up up no up no Ethanolamine+blood Weight+clinic 0.566563467 0 0 serum_aminoacids clinic 0.122 0.00971 up no no no up no Ferroptosis Weight+clinic 0.531338227 0 0 kegg clinic NA 0.00971 no no no no up no Fluid shear stress and atherosclerosis Weight+clinic 0.436476567 0 0 kegg clinic NA 0.00971 no no no no up no Gastric acid secretion Weight+clinic 0.463579898 0 0 kegg clinic NA 0.00971 no no no no up no Gastric cancer Weight+clinic -0.422924901 0 0 kegg clinic NA 0.00971 no no no no up no Glioma Weight+clinic 0 0 0.430812325 kegg clinic NA 0.00971 no no no no up no Glutamatergic synapse Weight+clinic 0.470355731 0 0 kegg clinic NA 0.00971 no up up no up no Glycine+blood Weight+clinic 0.620227038 0 0 serum_aminoacids clinic 0.00408 0.00971 dn no up no up no HDCA+stool Weight+clinic 0.629411765 0 0 stool_bileacids clinic 0.176 0.00971 no no no no up no Hepatitis B Weight+clinic -0.469226426 0 0 kegg clinic NA 0.00971 no no no no up no Hepatitis C Weight+clinic -0.43083004 0 0 kegg clinic NA 0.00971 no no no no up no Hippuric acid+urine Weight+clinic -0.535603715 0 0 urine_cometabolism clinic 0.361 0.00971 no no no no up no Insulin resistance Weight+clinic -0.522303783 0 0 kegg clinic NA 0.00971 no no no no up no L-Aspartic acid+blood Weight+clinic 0.620227038 0 0 yes serum_aminoacids clinic 0.0226 0.00971 up up no no up no L-Phenylalanine+stool Weight+clinic 0 0 -0.463579898 stool_cometabolism clinic 0.398 0.00971 no no no no up no L-Tyrosine+stool Weight+clinic 0 0 -0.462450593 stool_cometabolism clinic 0.44 0.00971 no no no no up no LCA+stool Weight+clinic 0 -0.627272727 0 stool_bileacids clinic 0.314 0.00971 no no no no up no Legionellosis Weight+clinic 0 0.602597403 0 kegg clinic NA 0.00971 no no no no up no Leishmaniasis Weight+clinic 0 0.52987013 0 kegg clinic NA 0.00971 no no no no up no Long-term potentiation Weight+clinic 0 0 0.560784314 kegg clinic NA 0.00971 no no up no up no Malaria Weight+clinic 0.473743648 0 0 kegg clinic NA 0.00971 no no no no up no Measles Weight+clinic 0 0.450649351 0 kegg clinic NA 0.00971 no no no no up no MIP-1b Weight+clinic 0 0 0.500985222 serum_cytokines clinic 0.632 0.00971 no no no no up no Neurotrophin signaling pathway Weight+clinic -0.440993789 0 0 kegg clinic NA 0.00971 no no no no up no NF-kappa B signaling pathway Weight+clinic -0.480519481 0 0 kegg clinic NA 0.00971 no no no no up no Non-small cell lung cancer Weight+clinic 0 0 0.417927171 kegg clinic NA 0.00971 no no no no up no Oocyte meiosis Weight+clinic 0 0 0.495798319 kegg clinic NA 0.00971 no no no no up no Oxytocin signaling pathway Weight+clinic 0.456804065 0 0 kegg clinic NA 0.00971 no no no no up no P-hydroxyhippuric acid+urine Weight+clinic -0.484004128 0 0 urine_cometabolism clinic 0.436 0.00971 no no no no up no Pancreatic cancer Weight+clinic -0.466967815 0 0 kegg clinic NA 0.00971 no no no no up no PI3K-Akt signaling pathway Weight+clinic 0 0.618181818 0 yes kegg clinic NA 0.00971 no up up no up no Platelet activation Weight+clinic 0.469226426 0 0 kegg clinic NA 0.00971 no no no no up no Prostate cancer Weight+clinic -0.521174478 0 0 kegg clinic NA 0.00971 no no no no up no RANTES Weight+clinic 0 0 0.519211823 yes serum_cytokines clinic 0.0757 0.00971 no no up no up no Ras signaling pathway Weight+clinic -0.479390175 0 0.477310924 yes kegg clinic NA 0.00971 no up up no up no Renin secretion Weight+clinic 0.462450593 0 0 kegg clinic NA 0.00971 no no no no up no Retrograde endocannabinoid signaling Weight+clinic 0 0 0.433333333 kegg clinic NA 0.00971 no no up no up no Roseburia Weight+clinic 0.548418972 0 0 butyrate-producing Genus clinic 0.495 0.00971 no no no no up no Ruminococcus Weight+clinic 0.449604743 0 0 acetate-producing Genus clinic 0.335 0.00971 no no no no up no Serotonergic synapse Weight+clinic 0.559570864 0 0 kegg clinic NA 0.00971 no no no no up no Signaling pathways regulating pluripotency of stem cells Weight+clinic 0 0 0.433613445 kegg clinic NA 0.00971 no no no no up no Small cell lung cancer Weight+clinic -0.427442123 0 0 kegg clinic NA 0.00971 no no up no up no T cell receptor signaling pathway Weight+clinic -0.445511011 0 0 kegg clinic NA 0.00971 no no no no up no TLCA+stool Weight+clinic -0.543344105 0 0 stool_bileacids clinic 0.243 0.00971 no no no no up no Transcriptional misregulation in cancer Weight+clinic -0.583286279 0 0 kegg clinic NA 0.00971 no no no no up no Vibrio cholerae infection Weight+clinic 0.446640316 0 0 kegg clinic NA 0.00971 no no no no up no 2-Oxocarboxylic acid metabolism Wnt signaling pathway 0 0.754940711 0 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Wnt signaling pathway 0.523478261 0.666007905 0.43037323 kegg kegg NA NA no no up no no no Akkermansia Wnt signaling pathway -0.428387973 0 0 acetate-producing Genus kegg 0.23 NA no no no no no no "Alanine, aspartate and glutamate metabolism" Wnt signaling pathway -0.534782609 -0.875494071 -0.665637066 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Wnt signaling pathway -0.657391304 -0.597826087 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Wnt signaling pathway -0.66173913 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Wnt signaling pathway -0.465217391 0.552371542 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Wnt signaling pathway 0 0 -0.475933076 kegg kegg NA NA no no no no no no Antifolate resistance Wnt signaling pathway 0 0.53458498 0.536164736 kegg kegg NA NA no no no no no no Apoptosis Wnt signaling pathway 0 -0.707509881 -0.468468468 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Wnt signaling pathway 0 0 -0.599485199 kegg kegg NA NA no no no no no no Arginine and proline metabolism Wnt signaling pathway -0.574782609 -0.821146245 -0.414671815 kegg kegg NA NA no up no no no no Arginine biosynthesis Wnt signaling pathway -0.550434783 -0.906126482 -0.745945946 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Wnt signaling pathway 0 0.443675889 0.405148005 kegg kegg NA NA no no no no no no Autophagy - animal Wnt signaling pathway 0 -0.631422925 0 kegg kegg NA NA no no no no no no Autophagy - other Wnt signaling pathway 0 0 0.644015444 kegg kegg NA NA no no no no no no Basal transcription factors Wnt signaling pathway 0 0.563241107 0.674646075 kegg kegg NA NA no no no no no no Base excision repair Wnt signaling pathway 0 0.545454545 0.413642214 kegg kegg NA NA no no no no no no beta-Alanine metabolism Wnt signaling pathway -0.585217391 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Wnt signaling pathway -0.73826087 -0.833003953 -0.787902188 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Wnt signaling pathway 0 0.47826087 -0.512998713 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Wnt signaling pathway -0.42173913 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Wnt signaling pathway 0 0.661067194 0 kegg kegg NA NA no no no no no no Calcium signaling pathway Wnt signaling pathway 0.734782609 0.555335968 0.461518662 kegg kegg NA NA no up up no no no cAMP signaling pathway Wnt signaling pathway 0.597391304 0 0 yes kegg kegg NA NA no up up no no no Carbon metabolism Wnt signaling pathway -0.644347826 0 -0.562162162 kegg kegg NA NA no no no no no no Cardiac muscle contraction Wnt signaling pathway 0.71826087 0.679841897 0.497297297 kegg kegg NA NA no no up no no no Cell cycle Wnt signaling pathway 0 0.805335968 0.776576577 kegg kegg NA NA no no no no no no Cellular senescence Wnt signaling pathway 0 -0.454545455 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Wnt signaling pathway 0 -0.871541502 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Wnt signaling pathway 0 -0.682806324 0 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Wnt signaling pathway 0 0.625494071 0 kegg kegg NA NA no no no no no no Collinsella Wnt signaling pathway 0 0 -0.435292927 Genus kegg 0.128 NA no no no no no no Cysteine and methionine metabolism Wnt signaling pathway 0 0.589920949 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Wnt signaling pathway 0 -0.421936759 0 kegg kegg NA NA no no no no no no DNA replication Wnt signaling pathway 0 0.778656126 0.55006435 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Wnt signaling pathway -0.44173913 0.697628458 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Wnt signaling pathway -0.562608696 0.659090909 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Wnt signaling pathway 0 0.596837945 0 kegg kegg NA NA no no no no no no Endocrine resistance Wnt signaling pathway 0.429565217 0 0 kegg kegg NA NA no no no no no no Endocytosis Wnt signaling pathway 0 -0.469367589 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Wnt signaling pathway 0 0 0.63963964 kegg kegg NA NA no no no no no no Ether lipid metabolism Wnt signaling pathway 0.75826087 0.581027668 0.566537967 kegg kegg NA NA no no no no no no Fanconi anemia pathway Wnt signaling pathway 0 0.4743083 0.564993565 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Wnt signaling pathway -0.524347826 -0.850790514 0 kegg kegg NA NA no no no no no no Fatty acid degradation Wnt signaling pathway -0.663478261 -0.635375494 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Wnt signaling pathway -0.692173913 -0.710474308 0 kegg kegg NA NA no no no no no no Ferroptosis Wnt signaling pathway 0 0 -0.588416988 kegg kegg NA NA no no no no no no Folate biosynthesis Wnt signaling pathway 0 0.76284585 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Wnt signaling pathway -0.660869565 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Wnt signaling pathway -0.572173913 -0.43972332 0 kegg kegg NA NA no no no no no no Glutathione metabolism Wnt signaling pathway 0 0.496047431 -0.577863578 kegg kegg NA NA no no no no no no Glycerolipid metabolism Wnt signaling pathway 0 0 0.701158301 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Wnt signaling pathway 0 0 0.752380952 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Wnt signaling pathway 0 0 -0.525353925 kegg kegg NA NA no up no no no no Glycolysis / Gluconeogenesis Wnt signaling pathway -0.70173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Wnt signaling pathway 0 -0.535573123 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Wnt signaling pathway 0 0.742094862 0.629343629 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Wnt signaling pathway 0.753913043 0.60770751 0.601029601 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Wnt signaling pathway 0 -0.502964427 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Wnt signaling pathway 0 0.499011858 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Wnt signaling pathway 0.697391304 0 0.52998713 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Wnt signaling pathway -0.606086957 -0.920948617 -0.6998713 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Wnt signaling pathway 0 0.494071146 0 kegg kegg NA NA no no no no no no Homologous recombination Wnt signaling pathway 0 0 0.462805663 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Wnt signaling pathway 0 0 0.657400257 kegg kegg NA NA no no no no no no Linoleic acid metabolism Wnt signaling pathway 0 0 0.431145431 kegg kegg NA NA no no no no no no Lysine degradation Wnt signaling pathway 0 0.508893281 0.844272844 kegg kegg NA NA no no no no no no Lysosome Wnt signaling pathway 0 -0.644268775 -0.418275418 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Wnt signaling pathway 0.750434783 0.526679842 0.877477477 kegg kegg NA NA no no no no no no MAPK signaling pathway Wnt signaling pathway 0 0 0.54980695 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Wnt signaling pathway -0.506956522 0.630434783 0 kegg kegg NA NA no no no no no no Mismatch repair Wnt signaling pathway 0 0.502964427 0 kegg kegg NA NA no no no no no no Mitophagy - animal Wnt signaling pathway 0.413913043 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Wnt signaling pathway 0.737391304 0.87055336 0.884427284 kegg kegg NA NA no no no no no no mTOR signaling pathway Wnt signaling pathway 0 0.579051383 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Wnt signaling pathway 0 0.928853755 0.612612613 kegg kegg NA NA no no no no no no Necroptosis Wnt signaling pathway 0 0 -0.577348777 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Wnt signaling pathway 0 -0.631422925 -0.51016731 kegg kegg NA NA up up up no no no NF-kappa B signaling pathway Wnt signaling pathway 0 -0.618577075 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Wnt signaling pathway -0.510434783 -0.87055336 -0.490862291 kegg kegg NA NA no no no no no no Nitrogen metabolism Wnt signaling pathway -0.530434783 -0.885375494 -0.671299871 kegg kegg NA NA no no no no no no Non-homologous end-joining Wnt signaling pathway -0.5 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Wnt signaling pathway 0 0.634387352 0 kegg kegg NA NA no no no no no no One carbon pool by folate Wnt signaling pathway 0 0.714426877 0.598970399 kegg kegg NA NA no no no no no no Oocyte meiosis Wnt signaling pathway 0 0.515810277 0.620849421 kegg kegg NA NA no no no no no no Other glycan degradation Wnt signaling pathway -0.443478261 0 0.503989704 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Wnt signaling pathway 0.432173913 0.423913043 0.792277992 kegg kegg NA NA no no no no no no Oxidative phosphorylation Wnt signaling pathway 0.707826087 0.639328063 0.404890605 kegg kegg NA NA no no no no no no p53 signaling pathway Wnt signaling pathway 0 0 0.430888031 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Wnt signaling pathway 0 -0.840909091 -0.464864865 kegg kegg NA NA no no dn no no no Paraprevotella Wnt signaling pathway 0 0.437974162 0 Genus kegg 0.118 NA no no no no no no Pentose and glucuronate interconversions Wnt signaling pathway 0 0.799407115 0.461003861 kegg kegg NA NA no no no no no no Pentose phosphate pathway Wnt signaling pathway 0 -0.757905138 -0.685714286 kegg kegg NA NA no no no no no no Peroxisome Wnt signaling pathway -0.573043478 -0.807312253 -0.686486486 kegg kegg NA NA no no no no no no Phagosome Wnt signaling pathway -0.46173913 -0.543478261 -0.527413127 kegg kegg NA NA no no no no no no Phenylalanine metabolism Wnt signaling pathway 0 0.559288538 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Wnt signaling pathway 0.690434783 0.540513834 0.887001287 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway Wnt signaling pathway 0 -0.576086957 0 kegg kegg NA NA no up up no no no Porphyrin and chlorophyll metabolism Wnt signaling pathway 0 0 -0.545688546 kegg kegg NA NA no no no no no no PPAR signaling pathway Wnt signaling pathway -0.495652174 -0.791501976 -0.406177606 kegg kegg NA NA no no no no no no Propanoate metabolism Wnt signaling pathway -0.423478261 0.508893281 0 kegg kegg NA NA no no no no no no Proteasome Wnt signaling pathway 0 0.443675889 0 kegg kegg NA NA no no no no no no Protein export Wnt signaling pathway 0.437391304 0.727272727 0.690862291 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Wnt signaling pathway 0 0.838932806 0 kegg kegg NA NA no no no no no no Purine metabolism Wnt signaling pathway 0 0.443675889 -0.432689833 kegg kegg NA NA no no no no no no Pyrimidine metabolism Wnt signaling pathway -0.675652174 0.639328063 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Wnt signaling pathway 0 0.634387352 0 kegg kegg NA NA no no no no no no Ras signaling pathway Wnt signaling pathway 0.489565217 0.791501976 0.826512227 yes kegg kegg NA NA no up up no no no Retinol metabolism Wnt signaling pathway -0.635652174 0 0 kegg kegg NA NA no no no no no no Ribosome Wnt signaling pathway 0.614782609 0.571146245 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Wnt signaling pathway 0 0.720355731 0.727670528 kegg kegg NA NA no no no no no no RNA degradation Wnt signaling pathway 0.765217391 0.931818182 0.880566281 kegg kegg NA NA no no no no no no RNA polymerase Wnt signaling pathway 0 0.814229249 0.610810811 kegg kegg NA NA no no no no no no RNA transport Wnt signaling pathway 0 0.539525692 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Wnt signaling pathway 0 0 0.545431145 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Wnt signaling pathway 0 0 0.51994852 kegg kegg NA NA no no no no no no Spliceosome Wnt signaling pathway 0 0 0.67001287 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Wnt signaling pathway -0.523478261 -0.777667984 0 kegg kegg NA NA no no no no no no Sulfur metabolism Wnt signaling pathway 0 0 -0.681853282 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Wnt signaling pathway 0 0.526679842 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Wnt signaling pathway 0 0 0.457400257 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Wnt signaling pathway 0 0 0.611068211 kegg kegg NA NA no no no no no no Thiamine metabolism Wnt signaling pathway 0 0.454545455 0 kegg kegg NA NA no no no no no no Tryptophan metabolism Wnt signaling pathway -0.409565217 0 0 kegg kegg NA NA no up no no no no Tyrosine metabolism Wnt signaling pathway -0.427826087 0.529644269 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Wnt signaling pathway 0 0.52173913 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Wnt signaling pathway 0.505217391 0.484189723 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Wnt signaling pathway 0 0.626482213 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Wnt signaling pathway 0 0.827075099 0.565508366 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Wnt signaling pathway 0.64 0.476284585 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Wnt signaling pathway 0 -0.518774704 0 kegg kegg NA NA no no no no no no Adherens junction Yersinia infection 0.584347826 0 0.764221364 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes Yersinia infection 0 -0.527667984 0 kegg kegg NA NA no no up no no no AGE-RAGE signaling pathway in diabetic complications Yersinia infection 0 0.509881423 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion Yersinia infection 0 -0.681818182 0 kegg kegg NA NA no up up no no no Aminoacyl-tRNA biosynthesis Yersinia infection 0 -0.442687747 0 kegg kegg NA NA no no no no no no Amphetamine addiction Yersinia infection 0 -0.770750988 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Yersinia infection -0.489565217 -0.725296443 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Yersinia infection 0 -0.473320158 0 kegg kegg NA NA no no no no no no Antifolate resistance Yersinia infection 0 -0.517786561 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Yersinia infection -0.554782609 -0.432806324 0 kegg kegg NA NA no no no no no no Apoptosis Yersinia infection 0.816521739 0.723320158 0.734877735 kegg kegg NA NA no no no no no no Apoptosis - multiple species Yersinia infection -0.627826087 -0.485177866 -0.588159588 kegg kegg NA NA no no no no no no Arginine and proline metabolism Yersinia infection 0.443478261 0.514822134 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Yersinia infection 0 0.472332016 0 kegg kegg NA NA no no no no no no Autophagy - other Yersinia infection -0.439130435 0 -0.471299871 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Yersinia infection 0 0.568181818 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Yersinia infection 0.68 0 0.756241956 kegg kegg NA NA no no no no no no Basal transcription factors Yersinia infection -0.62173913 -0.825098814 -0.567052767 kegg kegg NA NA no no no no no no Base excision repair Yersinia infection -0.654782609 -0.704545455 -0.53951094 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Yersinia infection 0.405217391 0.773715415 0.417503218 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Yersinia infection 0 -0.718379447 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Yersinia infection 0 0.522727273 0 kegg kegg NA NA no no no no no no Carbon metabolism Yersinia infection 0 0.529644269 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Yersinia infection 0 0.759881423 0.458429858 kegg kegg NA NA no no no no no no Cell cycle Yersinia infection -0.524347826 -0.796442688 -0.422393822 kegg kegg NA NA no no no no no no Cellular senescence Yersinia infection 0 0.705533597 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Yersinia infection 0 0.776679842 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Yersinia infection 0.471304348 0.713438735 0.592020592 kegg kegg NA NA no no no no no no Cholesterol metabolism Yersinia infection 0 0.62055336 0 yes kegg kegg NA NA no no up no no no Circadian rhythm Yersinia infection 0 -0.853754941 -0.536936937 kegg kegg NA NA no no no no no no Cocaine addiction Yersinia infection 0 -0.472332016 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Yersinia infection 0.460869565 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Yersinia infection 0.433043478 0.713438735 0.480566281 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion Yersinia infection 0 -0.650197628 0 kegg kegg NA NA no no up no no no Cushing syndrome Yersinia infection -0.417391304 -0.804347826 0 kegg kegg NA NA no no up no no no Cytokine-cytokine receptor interaction Yersinia infection 0 0 0.43037323 kegg kegg NA NA no no no no no no DNA replication Yersinia infection -0.495652174 -0.57312253 -0.446074646 kegg kegg NA NA no no no no no no Dopaminergic synapse Yersinia infection 0 -0.435770751 0 kegg kegg NA NA no up no no no no ECM-receptor interaction Yersinia infection -0.497391304 0 0 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance Yersinia infection -0.583478261 0 0 kegg kegg NA NA no no no no no no Eggerthella Yersinia infection 0 -0.441395835 0 Genus kegg 0.912 NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Yersinia infection 0 -0.501976285 0 kegg kegg NA NA no no no no no no Endocrine resistance Yersinia infection 0 -0.555335968 0 kegg kegg NA NA no no no no no no Endocytosis Yersinia infection 0.497391304 0.769762846 0.446589447 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Yersinia infection 0.631304348 0.783596838 0.520720721 kegg kegg NA NA no no no no no no Estrogen signaling pathway Yersinia infection 0 -0.5256917 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Yersinia infection 0 -0.682806324 0 kegg kegg NA NA no no no no no no Eubacterium Yersinia infection 0 0 -0.456340257 Genus kegg 0.0692 NA no no no no no no Fanconi anemia pathway Yersinia infection -0.494782609 -0.659090909 -0.544658945 kegg kegg NA NA no no no no no no Fat digestion and absorption Yersinia infection 0 0.610671937 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Yersinia infection 0 0.505928854 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Yersinia infection 0 0.652173913 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Yersinia infection 0.711304348 0.774703557 0.413127413 kegg kegg NA NA no no no no no no Focal adhesion Yersinia infection 0.539130435 0 0.588159588 kegg kegg NA NA no up up no no no Gastric acid secretion Yersinia infection 0.412173913 0 0.68983269 kegg kegg NA NA no no no no no no Glucagon signaling pathway Yersinia infection -0.545217391 -0.746047431 -0.411068211 kegg kegg NA NA no no no no no no Glutathione metabolism Yersinia infection -0.429565217 -0.584980237 0 kegg kegg NA NA no no no no no no Glycerophospholipid metabolism Yersinia infection -0.443478261 0 0 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Yersinia infection 0 -0.596837945 0 kegg kegg NA NA no up no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Yersinia infection 0.44173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Yersinia infection 0.613043478 0.575098814 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Yersinia infection 0 -0.517786561 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Yersinia infection -0.431304348 -0.613636364 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Yersinia infection 0 0.501976285 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Yersinia infection 0 -0.571146245 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Yersinia infection 0 -0.662055336 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Yersinia infection -0.597391304 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Yersinia infection 0 0 0.602831403 kegg kegg NA NA no no no no no no Homologous recombination Yersinia infection 0 -0.523715415 -0.606177606 kegg kegg NA NA no no no no no no Huntington disease Yersinia infection 0 -0.416996047 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Yersinia infection 0.546956522 0.749011858 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Yersinia infection 0 -0.565217391 0 kegg kegg NA NA no no no no no no Insulin secretion Yersinia infection -0.415652174 -0.619565217 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway Yersinia infection -0.613913043 -0.437747036 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Yersinia infection 0.726956522 0.501976285 0.775032175 kegg kegg NA NA no no no no no no Longevity regulating pathway Yersinia infection -0.443478261 -0.448616601 0 kegg kegg NA NA no no no no no no Lysine degradation Yersinia infection -0.58 -0.638339921 -0.473359073 kegg kegg NA NA no no no no no no Lysosome Yersinia infection 0.662608696 0.826086957 0.465122265 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Yersinia infection 0 -0.52173913 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young Yersinia infection 0 -0.489130435 0 kegg kegg NA NA no up no no no no Melanogenesis Yersinia infection 0 -0.48715415 0 kegg kegg NA NA no no no no no no Mismatch repair Yersinia infection 0 -0.485177866 0 kegg kegg NA NA no no no no no no Mitophagy - animal Yersinia infection 0 -0.441699605 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Yersinia infection -0.428695652 -0.754940711 -0.441184041 kegg kegg NA NA no no no no no no mTOR signaling pathway Yersinia infection -0.602608696 -0.437747036 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Yersinia infection 0 0 -0.418018018 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Yersinia infection -0.606956522 -0.631422925 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Yersinia infection 0.507826087 0.742094862 0 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction Yersinia infection 0.66173913 0.734189723 0.461518662 kegg kegg NA NA up up up no no no Neutrophil extracellular trap formation Yersinia infection 0.82 0.862648221 0.626254826 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Yersinia infection 0.419130435 0.601778656 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Yersinia infection 0 0.416007905 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Yersinia infection 0.497391304 0.489130435 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Yersinia infection -0.489565217 -0.649209486 -0.442471042 kegg kegg NA NA no no no no no no Olfactory transduction Yersinia infection 0.535652174 0.732213439 0 kegg kegg NA NA no no no no no no One carbon pool by folate Yersinia infection -0.422608696 -0.644268775 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Yersinia infection 0.712173913 0.698616601 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Yersinia infection -0.597391304 -0.71541502 -0.559073359 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Yersinia infection 0.591304348 0.470355731 0.61956242 kegg kegg NA NA no no no no no no p53 signaling pathway Yersinia infection -0.645217391 -0.551383399 -0.725611326 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis Yersinia infection 0.482608696 0.541501976 0 kegg kegg NA NA no no dn no no no "Parathyroid hormone synthesis, secretion and action" Yersinia infection 0 -0.416007905 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Yersinia infection 0.875652174 0.904150198 0.846074646 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Yersinia infection 0 -0.446640316 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Yersinia infection 0 -0.492094862 0 kegg kegg NA NA no no no no no no Pentose phosphate pathway Yersinia infection 0.66 0.852766798 0 kegg kegg NA NA no no no no no no Peroxisome Yersinia infection 0 0.43972332 0 kegg kegg NA NA no no no no no no Pertussis Yersinia infection 0.639130435 0.799407115 0.454568855 kegg kegg NA NA no no dn no no no Phagosome Yersinia infection 0.51826087 0.863636364 0.64015444 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Yersinia infection -0.435652174 -0.60770751 -0.416473616 kegg kegg NA NA no no no no no no Platelet activation Yersinia infection 0.520869565 0 0.758301158 kegg kegg NA NA no no no no no no Platinum drug resistance Yersinia infection -0.6 -0.535573123 -0.585585586 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Yersinia infection 0 -0.588932806 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Yersinia infection 0 0.570158103 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Yersinia infection 0 -0.456521739 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Yersinia infection 0 0.472332016 0 kegg kegg NA NA no no no no no no Protein export Yersinia infection -0.612173913 -0.459486166 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Yersinia infection -0.576521739 -0.736166008 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Yersinia infection 0 -0.522727273 0 kegg kegg NA NA no no no no no no Purine metabolism Yersinia infection -0.544347826 -0.628458498 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Yersinia infection 0 -0.495059289 -0.501415701 kegg kegg NA NA no no no no no no Pyruvate metabolism Yersinia infection 0 -0.488142292 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Yersinia infection 0.67826087 0 0.836808237 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Yersinia infection 0.570434783 0 0.425740026 kegg kegg NA NA no no no no no no Renin secretion Yersinia infection 0 -0.433794466 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Yersinia infection 0.517391304 0.747035573 0 kegg kegg NA NA no no no no no no Ribosome Yersinia infection -0.564347826 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Yersinia infection -0.717391304 -0.745059289 -0.497297297 kegg kegg NA NA no no no no no no RNA degradation Yersinia infection -0.443478261 -0.644268775 -0.405405405 kegg kegg NA NA no no no no no no RNA polymerase Yersinia infection -0.79826087 -0.788537549 0 kegg kegg NA NA no no no no no no RNA transport Yersinia infection -0.426956522 0 0 kegg kegg NA NA no no no no no no Salmonella infection Yersinia infection 0.706956522 0.772727273 0.691119691 kegg kegg NA NA no no no no no no Selenocompound metabolism Yersinia infection -0.57826087 -0.612648221 -0.555469755 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Yersinia infection 0 -0.532608696 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Yersinia infection 0.58173913 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Yersinia infection 0 0.535573123 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Yersinia infection -0.413043478 -0.648221344 0 kegg kegg NA NA no no no no no no Spliceosome Yersinia infection -0.65826087 -0.564229249 -0.554954955 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Yersinia infection 0.604347826 0.503952569 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Yersinia infection -0.505217391 -0.43972332 0 kegg kegg NA NA no no no no no no Synaptic vesicle cycle Yersinia infection 0.610434783 0.770750988 0 kegg kegg NA NA no up up no no no Synthesis and degradation of ketone bodies Yersinia infection 0 -0.623517787 0 kegg kegg NA NA no no no no no no Taste transduction Yersinia infection 0 -0.557312253 0 kegg kegg NA NA no no up no no no Terpenoid backbone biosynthesis Yersinia infection -0.422608696 -0.507905138 0 kegg kegg NA NA no no no no no no Thiamine metabolism Yersinia infection 0 -0.471343874 -0.418790219 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Yersinia infection 0.468695652 0 0.572972973 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Yersinia infection -0.557391304 -0.508893281 0 kegg kegg NA NA no no no no no no Tight junction Yersinia infection 0.533043478 0 0.623423423 kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Yersinia infection 0 0.60770751 0.420592021 yes kegg kegg NA NA no no no no no no Type I diabetes mellitus Yersinia infection 0 0.709486166 0.400514801 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Yersinia infection -0.467826087 -0.576086957 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Yersinia infection -0.488695652 -0.601778656 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Yersinia infection 0 -0.422924901 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Yersinia infection 0.519130435 0 0.784813385 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Yersinia infection 0 0.495059289 0.44993565 kegg kegg NA NA no no no no no no Wnt signaling pathway Yersinia infection 0 -0.617588933 0 kegg kegg NA NA no no no no no no 12-HEPE+blood Adrenergic signaling in cardiomyocytes 0 0 -0.410535099 serum_ARA kegg 0.312 NA no no no no no up 12-HEPE+blood Aldosterone synthesis and secretion 0 0 -0.47272071 serum_ARA kegg 0.312 NA no no no no up up 12-HEPE+blood Amphetamine addiction 0 0 -0.527752225 serum_ARA kegg 0.312 NA no no no no no no 12-HEPE+blood Bifidobacterium 0 -0.606317072 0 acetate-producing serum_ARA Genus 0.312 0.105 no no no no dn no 12-HEPE+blood Calcium signaling pathway 0 0 -0.405582262 serum_ARA kegg 0.312 NA no no no no up up 12-HEPE+blood Carbon metabolism 0 0 0.412736359 serum_ARA kegg 0.312 NA no no no no no no 12-HEPE+blood Dopaminergic synapse 0 0 -0.458962831 serum_ARA kegg 0.312 NA no no no no up no 12-HEPE+blood ErbB signaling pathway 0 0.58677406 0 serum_ARA kegg 0.312 NA no no no no no no 12-HEPE+blood Fc epsilon RI signaling pathway 0 0 0.485928274 serum_ARA kegg 0.312 NA no no no no no no 12-HEPE+blood GnRH signaling pathway 0 0 -0.516195607 serum_ARA kegg 0.312 NA no no no no no no 12-HEPE+blood GUDCA+stool 0 0.646202371 0 yes serum_ARA stool_bileacids 0.312 0.0085 no no no no dn no 12-HEPE+blood Hepatocellular carcinoma 0 0 0.463365353 serum_ARA kegg 0.312 NA no no no no no no 12-HEPE+blood Inflammatory mediator regulation of TRP channels 0 0 -0.525550964 serum_ARA kegg 0.312 NA no no no no no no 12-HEPE+blood Lysosome 0 0 0.477123231 serum_ARA kegg 0.312 NA no no no no no no 12-HEPE+blood Neuroactive ligand-receptor interaction 0 0 0.442453377 serum_ARA kegg 0.312 NA no no no up up up 12-HEPE+blood Non-small cell lung cancer 0 0.526370848 0 serum_ARA kegg 0.312 NA no no no no no no 12-HEPE+blood Peroxisome 0 0 0.421541402 serum_ARA kegg 0.312 NA no no no no no no 12-HEPE+blood Proteasome 0 -0.500483757 0 serum_ARA kegg 0.312 NA no no no no no no 12-HEPE+blood Renin secretion 0 -0.517741818 0 serum_ARA kegg 0.312 NA no no no no no no 12-ketoDCA+blood 11-HETE+blood 0 -0.551028023 0 serum_bileacids serum_ARA 0.517 0.464 no no no no no no 12-ketoDCA+blood Acetic acid+stool 0 0 -0.449941231 yes serum_bileacids stool_scfa 0.517 0.0656 no no no dn no no 12-ketoDCA+blood Alistipes 0 0 0.413298925 serum_bileacids Genus 0.517 0.0114 no no no no up no 12-ketoDCA+blood AMPK signaling pathway 0.528812891 0 0 serum_bileacids kegg 0.517 NA no no no no no no 12-ketoDCA+blood Anaerostipes 0.476855169 0 0 butyrate-producing serum_bileacids Genus 0.517 0.568 no no no no no no 12-ketoDCA+blood Bifidobacterium -0.45457709 0 0 acetate-producing serum_bileacids Genus 0.517 0.105 no no no no dn no 12-ketoDCA+blood Butyric acid+stool 0 0 -0.532871576 yes serum_bileacids stool_scfa 0.517 0.102 no no no dn no no 12-ketoDCA+blood Calcium signaling pathway 0 0.537084017 0 serum_bileacids kegg 0.517 NA no no no no up up 12-ketoDCA+blood Chemokine signaling pathway 0 0 0.400576758 serum_bileacids kegg 0.517 NA no no no no no no 12-ketoDCA+blood Clostridium 0 -0.573275344 0 serum_bileacids Genus 0.517 0.925 no no no no no no 12-ketoDCA+blood Cushing syndrome 0 0.500376836 0 serum_bileacids kegg 0.517 NA no no no no no up 12-ketoDCA+blood Cytokine-cytokine receptor interaction 0 0 0.576024902 serum_bileacids kegg 0.517 NA no no no no no no 12-ketoDCA+blood Endocrine resistance 0 0.550607716 0 serum_bileacids kegg 0.517 NA no no no no no no 12-ketoDCA+blood Estrogen signaling pathway 0 0 0.460103807 serum_bileacids kegg 0.517 NA no no no no no no 12-ketoDCA+blood GCA+stool 0 -0.606779876 0 serum_bileacids stool_bileacids 0.517 0.0809 no no no no no no 12-ketoDCA+blood GnRH signaling pathway 0 0.600838595 0 serum_bileacids kegg 0.517 NA no no no no no no 12-ketoDCA+blood L-Phenylalanine+stool -0.644251775 0 0 serum_bileacids stool_cometabolism 0.517 0.398 no no no no no no 12-ketoDCA+blood L-Tryptophan+stool -0.711361335 0 0 serum_bileacids stool_cometabolism 0.517 0.557 no no no no no no 12-ketoDCA+blood L-Tyrosine+stool -0.671095599 0 0 serum_bileacids stool_cometabolism 0.517 0.44 no no no no no no 12-ketoDCA+blood Longevity regulating pathway - multiple species 0 -0.527424233 0 serum_bileacids kegg 0.517 NA no no no no no no 12-ketoDCA+blood mTOR signaling pathway 0.489459373 0 0 serum_bileacids kegg 0.517 NA no no no no no no 12-ketoDCA+blood Prevotella 0.516526535 0 0 acetate-producing serum_bileacids Genus 0.517 0.287 no no no no no no 12-ketoDCA+blood Regulation of actin cytoskeleton 0 -0.502308793 0 serum_bileacids kegg 0.517 NA no no no no no no 12-ketoDCA+blood Renin secretion 0 0 0.409975765 serum_bileacids kegg 0.517 NA no no no no no no 12-ketoDCA+blood RNA transport 0.459944235 0 0 serum_bileacids kegg 0.517 NA no no no no no no 12-ketoDCA+blood Salivary secretion 0 0 0.441753363 serum_bileacids kegg 0.517 NA no no no no no no 12-ketoDCA+blood T cell receptor signaling pathway 0 0.525492276 0 serum_bileacids kegg 0.517 NA no no no no no no 12-ketoDCA+blood TDCA+stool 0 -0.690065559 0 serum_bileacids stool_bileacids 0.517 0.963 no no no no no no 12-ketoDCA+blood total_stool_cometabolism+stool -0.691228467 0 0 serum_bileacids stool_cometabolism 0.517 0.707 no no no no no no 12-ketoDCA+blood total_stool_scfa+stool 0 0 -0.472879412 serum_bileacids stool_scfa 0.517 0.0534 no no no dn no up 12-ketoDCA+blood Viral protein interaction with cytokine and cytokine receptor 0 0 0.405500047 serum_bileacids kegg 0.517 NA no no no no no no 12-ketoDCA+stool Akkermansia 0 0 0.632422322 acetate-producing stool_bileacids Genus 0.505 0.23 no no no no no no 12-ketoDCA+stool Alistipes 0 0 0.419515898 stool_bileacids Genus 0.505 0.0114 no no no no up no 12-ketoDCA+stool Allograft rejection 0 -0.806380224 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Antigen processing and presentation 0 -0.788156942 0.422924901 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Apoptosis -0.570691434 0 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Autoimmune thyroid disease 0 -0.806380224 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Blautia 0 0 -0.434223753 acetate-producing stool_bileacids Genus 0.505 1.36E-05 no no no up dn dn 12-ketoDCA+stool Breast cancer 0 0.706152174 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Carbon metabolism 0 -0.615035764 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Cell adhesion molecules 0 -0.719819635 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Cellular senescence 0 -0.756266199 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Chemical carcinogenesis - receptor activation 0 0.760822019 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Choline metabolism in cancer 0 0.719819635 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Cholinergic synapse 0 0.615035764 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Colorectal cancer 0 0.610479944 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Cortisol synthesis and secretion 0 0.615035764 0 stool_bileacids kegg 0.505 NA no no no no no up 12-ketoDCA+stool Cushing syndrome 0 0.651482328 0 stool_bileacids kegg 0.505 NA no no no no no up 12-ketoDCA+stool Endocrine resistance 0 0.724375456 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Endocytosis 0 -0.728931276 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Epstein-Barr virus infection 0 -0.683373071 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Estrogen signaling pathway 0 0 0.483907397 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Fc epsilon RI signaling pathway 0 0 -0.43083004 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool GnRH signaling pathway 0 0.646926508 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Graft-versus-host disease 0 -0.806380224 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Herpes simplex virus 1 infection 0 -0.701596353 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Human cytomegalovirus infection 0 -0.692484712 0 stool_bileacids kegg 0.505 NA no no no no no dn 12-ketoDCA+stool Human immunodeficiency virus 1 infection 0 -0.683373071 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Human papillomavirus infection 0 -0.715263815 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Human T-cell leukemia virus 1 infection 0 -0.742598738 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Legionellosis 0 0 0.539243365 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Leishmaniasis 0 0 0.521174478 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Leukocyte transendothelial migration 0 -0.628703226 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Lipid and atherosclerosis -0.469556244 0 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Longevity regulating pathway 0 0.706152174 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Longevity regulating pathway - multiple species 0 0 0.557312253 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Mitophagy - animal 0 0 0.426312818 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Natural killer cell mediated cytotoxicity 0 -0.756266199 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool NOD-like receptor signaling pathway 0 0 0.45567476 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Odoribacter 0 -0.644484351 0 butyrate-producing stool_bileacids Genus 0.505 0.798 no no no no no no 12-ketoDCA+stool p53 signaling pathway 0 0.76993366 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Pathogenic Escherichia coli infection -0.479876161 -0.642370687 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Pathways in cancer 0 0.628703226 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Phagosome 0 -0.646926508 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Protein processing in endoplasmic reticulum 0 0 0.504234896 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Purine metabolism 0.543859649 0 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Renin secretion 0 0 0.426312818 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Salmonella infection 0 -0.756266199 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Shigellosis 0 0 0.47826087 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Signaling pathways regulating pluripotency of stem cells 0 0.660593969 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Thyroid hormone synthesis 0.475748194 0 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Type I diabetes mellitus 0 -0.806380224 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Ubiquitin mediated proteolysis 0 0 0.456804065 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Viral carcinogenesis 0 -0.651482328 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Viral myocarditis 0 -0.810936045 0 stool_bileacids kegg 0.505 NA no no no no no no 12-ketoDCA+stool Yersinia infection -0.531475748 -0.633259046 0 stool_bileacids kegg 0.505 NA no no no no no no "12,13-EPOME+blood" 4-hydroxybenzoic acid+stool 0 0 -0.451439041 serum_ARA stool_cometabolism 0.901 0.0536 no no no no dn no "12,13-EPOME+blood" AGE-RAGE signaling pathway in diabetic complications 0 0 0.519313272 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" AMPK signaling pathway -0.526739424 0 0 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Antigen processing and presentation 0.491499814 0 0 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Arachidonic acid metabolism 0 0 -0.617444375 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Arginine and proline metabolism 0.52859414 0 0 serum_ARA kegg 0.901 NA no no no no up no "12,13-EPOME+blood" Breast cancer 0 0 0.417708501 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Butyricicoccus 0 0.493492183 0 butyrate-producing serum_ARA Genus 0.901 0.852 no no no no no no "12,13-EPOME+blood" Cell cycle 0 0 0.427261087 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Choline metabolism in cancer 0 -0.575295083 0.472418763 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Cholinergic synapse 0 0 0.414234834 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Clostridium 0 0.643797615 0 serum_ARA Genus 0.901 0.925 no no no no no no "12,13-EPOME+blood" Colorectal cancer 0 0 0.495866017 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Cushing syndrome -0.506337545 0 0 serum_ARA kegg 0.901 NA no no no no no up "12,13-EPOME+blood" DCA+stool 0 0 0.532086261 serum_ARA stool_bileacids 0.901 0.195 no no no no no no "12,13-EPOME+blood" ErbB signaling pathway 0 -0.507346845 0.484576598 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Ferroptosis 0 0 -0.497602851 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" FoxO signaling pathway 0 -0.513386688 0 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" GABAergic synapse 0.504482828 0 0 serum_ARA kegg 0.901 NA no no no no up up "12,13-EPOME+blood" Gap junction 0 0 -0.417708501 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Gastric cancer 0 -0.546605827 0.484576598 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Gemmiger 0 -0.543731339 0 butyrate-producing serum_ARA Genus 0.901 0.595 no no no no no no "12,13-EPOME+blood" Glioma 0 0 0.506287019 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Glutamatergic synapse 0 0 -0.479366097 serum_ARA kegg 0.901 NA no no no no up up "12,13-EPOME+blood" Glutathione metabolism 0 0 -0.515839605 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" "Glycine, serine and threonine metabolism" 0 0 -0.402076998 serum_ARA kegg 0.901 NA no no no no up no "12,13-EPOME+blood" HDCA+stool 0 0 0.496861038 serum_ARA stool_bileacids 0.901 0.176 no no no no no no "12,13-EPOME+blood" Hepatitis B 0 0 0.401208581 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Hepatitis C 0 0 0.400340165 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Herpes simplex virus 1 infection 0.46367907 0 0 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Insulin resistance 0 -0.536036101 0.533207942 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" JAK-STAT signaling pathway 0 -0.513386688 0 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Kaposi sarcoma-associated herpesvirus infection 0 0 -0.409024333 serum_ARA kegg 0.901 NA no no no no no dn "12,13-EPOME+blood" LCA+stool 0 0 0.462562795 serum_ARA stool_bileacids 0.901 0.314 no no no no no no "12,13-EPOME+blood" Lipid and atherosclerosis 0.617620521 0 0 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Long-term potentiation 0 0 0.408155916 serum_ARA kegg 0.901 NA no no no no no up "12,13-EPOME+blood" Malaria 0 0 -0.486313432 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" MAPK signaling pathway 0 0 0.416840085 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" MicroRNAs in cancer 0 0 0.549707862 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Mineral absorption 0 0 -0.481971348 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Mitophagy - animal -0.511901693 0 -0.424655836 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Necroptosis 0 0 -0.464603011 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" NOD-like receptor signaling pathway 0.497063963 0 0 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Non-small cell lung cancer 0 -0.549625748 0.456787259 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Oxytocin signaling pathway 0 0 -0.467208261 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Pancreatic cancer 0 0 0.444629424 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Parkinson disease 0 0 -0.401208581 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Pathways in cancer 0 -0.540565983 0.476760847 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Pathways of neurodegeneration - multiple diseases 0 0 -0.440287339 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 0.570549866 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Peroxisome 0.515611126 0 0 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Pertussis 0.485935665 0 0 serum_ARA kegg 0.901 NA no no no no no dn "12,13-EPOME+blood" Phosphatidylinositol signaling system 0 0 0.565339365 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Porphyrin and chlorophyll metabolism 0 0 -0.434208421 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Progesterone-mediated oocyte maturation 0 0 0.424655836 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Prolactin signaling pathway 0 0 0.434208421 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Prostate cancer 0 0 0.413366417 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Ribosome biogenesis in eukaryotes 0 0 0.425524253 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" RNA degradation 0 0 0.52539219 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Ruminococcus 0 0.65052357 0 serum_ARA Genus 0.901 0.0679 no no no no no dn "12,13-EPOME+blood" Salivary secretion 0 0 -0.422050586 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Shigellosis -0.4785168 0 -0.488918683 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Signaling pathways regulating pluripotency of stem cells 0 -0.529996257 0.455050426 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Small cell lung cancer 0 -0.549625748 0 serum_ARA kegg 0.901 NA no no no no no up "12,13-EPOME+blood" Spinocerebellar ataxia 0 0 0.501944935 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Spliceosome 0 0 0.464603011 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Th1 and Th2 cell differentiation 0 0 0.461129344 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Th17 cell differentiation 0 0 0.565339365 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Thyroid hormone synthesis 0 0 -0.477629264 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Tight junction 0 0.5707652 0 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Transcriptional misregulation in cancer 0 0 0.420313752 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Ubiquitin mediated proteolysis -0.510046977 0 0 serum_ARA kegg 0.901 NA no no no no no no "12,13-EPOME+blood" Wnt signaling pathway 0 0 0.481971348 serum_ARA kegg 0.901 NA no no no no no no 13-HODE+blood 11-HETE+blood 0 0 -0.489187164 serum_ARA serum_ARA 0.32 0.464 no no no no no no 13-HODE+blood "12,13-EPOME+blood" 0 0 0.495991738 serum_ARA serum_ARA 0.32 0.901 no no no no no no 13-HODE+blood Adrenergic signaling in cardiomyocytes 0.5 0 -0.413846154 serum_ARA kegg 0.32 NA no no no no no up 13-HODE+blood Alcoholism 0 0 -0.523846154 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood Amphetamine addiction 0 0 -0.425384615 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood Bifidobacterium 0.505453214 0 0 acetate-producing serum_ARA Genus 0.32 0.105 no no no no dn no 13-HODE+blood Central carbon metabolism in cancer 0 -0.676470588 0 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood Chemokine signaling pathway 0 0.588235294 0 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood Circadian entrainment 0 0 -0.5 serum_ARA kegg 0.32 NA no no no no up up 13-HODE+blood Dopaminergic synapse 0 0 -0.491538462 serum_ARA kegg 0.32 NA no no no no up no 13-HODE+blood Endocrine and other factor-regulated calcium reabsorption 0 0 -0.44 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood Ferroptosis 0 0 -0.514615385 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood FoxO signaling pathway 0 0 0.414615385 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood Gap junction 0 0.514705882 0 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood JAK-STAT signaling pathway 0 0 0.512307692 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood Lachnospira -0.511278195 0 0 butyrate-producing serum_ARA Genus 0.32 0.279 no no no no no no 13-HODE+blood Long-term depression 0 0 -0.437692308 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood Long-term potentiation 0.477192982 0 0 serum_ARA kegg 0.32 NA no no no no no up 13-HODE+blood Mineral absorption 0 0 -0.524615385 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood Morphine addiction 0 0 -0.449230769 serum_ARA kegg 0.32 NA no no no no up up 13-HODE+blood Necroptosis 0 0 -0.472307692 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood NOD-like receptor signaling pathway 0 0 0.489230769 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood nutriCA+stool 0 -0.688102353 0 serum_ARA stool_bileacids 0.32 0.481 no no no no no no 13-HODE+blood Pancreatic secretion 0 0 -0.442307692 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood Paraprevotella 0.475238873 0 0 serum_ARA Genus 0.32 0.118 no no no no no no 13-HODE+blood Relaxin signaling pathway 0 0.523529412 0 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood Renin secretion 0 0 -0.424615385 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood Vascular smooth muscle contraction 0 0 -0.479230769 serum_ARA kegg 0.32 NA no no no no no no 13-HODE+blood Vasopressin-regulated water reabsorption 0 0 -0.446923077 serum_ARA kegg 0.32 NA no no no no no no 14:0-LPC+blood 14:0+blood 0.610526316 0.492647059 0.802393162 yes serum_phospholipids serum_fattyacid 0.00689 0.00572 up up no up no dn 14:0/16:0-PC+blood 11-HETE+blood 0 0.671085173 0 serum_phospholipids serum_ARA 0.0358 0.464 no up no no no no 14:0/16:0-PC+blood 12-ketoDCA+blood 0.519474976 0 0 serum_phospholipids serum_bileacids 0.0358 0.517 no up no no no no 14:0/16:0-PC+blood 14:0-LPC+blood 0.457142857 0.507352941 0.742222222 serum_phospholipids serum_phospholipids 0.0358 0.00689 no up no up up no 14:0/16:0-PC+blood 14:0+blood 0 0.541666667 0.69982906 yes serum_phospholipids serum_fattyacid 0.0358 0.00572 no up no up no dn 14:0/16:0-PC+blood Bacterial invasion of epithelial cells 0 0 -0.507692308 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood cGMP-PKG signaling pathway 0 0 -0.444615385 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood Clostridium 0 0 -0.490268105 serum_phospholipids Genus 0.0358 0.925 no up no no no no 14:0/16:0-PC+blood Focal adhesion 0 0 -0.501538462 serum_phospholipids kegg 0.0358 NA no up no no up up 14:0/16:0-PC+blood Hippo signaling pathway 0 0 -0.457692308 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood Hypertrophic cardiomyopathy 0 0 -0.431538462 serum_phospholipids kegg 0.0358 NA no up no no up up 14:0/16:0-PC+blood Kaposi sarcoma-associated herpesvirus infection 0 0 0.475384615 serum_phospholipids kegg 0.0358 NA no up no no no dn 14:0/16:0-PC+blood Leukocyte transendothelial migration 0 0 -0.469230769 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood Malaria 0 0 0.450769231 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood Mitophagy - animal 0 0 0.476923077 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood Neuroactive ligand-receptor interaction 0 0 -0.493846154 serum_phospholipids kegg 0.0358 NA no up no up up up 14:0/16:0-PC+blood Odoribacter 0 0 -0.428675962 butyrate-producing serum_phospholipids Genus 0.0358 0.798 no up no no no no 14:0/16:0-PC+blood Parkinson disease 0 0 0.433846154 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood Pathways of neurodegeneration - multiple diseases 0 0 0.451538462 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood Platelet activation 0 0 -0.463076923 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood Porphyrin and chlorophyll metabolism 0 0 0.421538462 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood Purine metabolism 0 0 0.409230769 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood Rap1 signaling pathway 0 0 -0.429230769 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood Regulation of actin cytoskeleton 0 0 -0.47 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood Salmonella infection 0 0 -0.47 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood Sphingolipid signaling pathway 0 0 -0.461538462 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/16:0-PC+blood Ubiquitin mediated proteolysis 0 0 0.499230769 serum_phospholipids kegg 0.0358 NA no up no no no no 14:0/18:0-PC+blood 11-HETE+blood 0 0.72270711 0 serum_phospholipids serum_ARA 0.00289 0.464 up up no no no no 14:0/18:0-PC+blood 14:0-LPC+blood 0 0.514705882 0.530940171 serum_phospholipids serum_phospholipids 0.00289 0.00689 up up no up up no 14:0/18:0-PC+blood 14:0/16:0-PC+blood 0.530827068 0.784313725 0.798974359 serum_phospholipids serum_phospholipids 0.00289 0.0358 up up no no up no 14:0/18:0-PC+blood 14:0+blood 0 0 0.497435897 yes serum_phospholipids serum_fattyacid 0.00289 0.00572 up up no up no dn 14:0/18:2-PC+blood 14:0-LPC+blood 0.62556391 0.580882353 0.807863248 serum_phospholipids serum_phospholipids 0.102 0.00689 no up no up up no 14:0/18:2-PC+blood 14:0/16:0-PC+blood 0.571428571 0.568627451 0.648547009 serum_phospholipids serum_phospholipids 0.102 0.0358 no up no no up no 14:0/18:2-PC+blood 14:0+blood 0.538345865 0 0.783247863 yes serum_phospholipids serum_fattyacid 0.102 0.00572 no up no up no dn 14:0/18:2-PC+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0.565934066 0 0 serum_phospholipids stool_cometabolism 0.102 0.33 no up no no no no 14:0/18:2-PC+blood AMPK signaling pathway 0 0 0.488461538 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood Biosynthesis of cofactors 0 0 0.440769231 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood Blautia 0 -0.534313725 0 acetate-producing serum_phospholipids Genus 0.102 1.36E-05 no up no up dn dn 14:0/18:2-PC+blood Carbon metabolism 0 0 -0.437692308 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood cGMP-PKG signaling pathway 0 0 -0.678461538 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood Clostridium 0.45656265 0 -0.410375169 serum_phospholipids Genus 0.102 0.925 no up no no no no 14:0/18:2-PC+blood Coprococcus 0 -0.605392157 0 butyrate-producing serum_phospholipids Genus 0.102 0.612 no up no no no no 14:0/18:2-PC+blood Fc gamma R-mediated phagocytosis 0 0 -0.478461538 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood "Glycine, serine and threonine metabolism" 0 0 0.433076923 serum_phospholipids kegg 0.102 NA no up no no up no 14:0/18:2-PC+blood HIF-1 signaling pathway 0 0.564705882 0 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood IL-17 signaling pathway 0 0 -0.437692308 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood Legionellosis 0.568421053 0 0 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood Leishmaniasis 0.496491228 0 0 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood Lipid and atherosclerosis 0 0 -0.440769231 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood Longevity regulating pathway 0 0 0.473846154 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood Lysosome 0 0 -0.508461538 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood Neuroactive ligand-receptor interaction 0 0 -0.681538462 serum_phospholipids kegg 0.102 NA no up no up up up 14:0/18:2-PC+blood Neutrophil extracellular trap formation 0 0 -0.407692308 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood Pertussis 0 0 -0.400769231 serum_phospholipids kegg 0.102 NA no up no no no dn 14:0/18:2-PC+blood Phenylacetic acid+stool -0.648351648 0 0 serum_phospholipids stool_cometabolism 0.102 0.785 no up no no no no 14:0/18:2-PC+blood Porphyrin and chlorophyll metabolism 0 0 0.429230769 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood RNA transport 0.535087719 0 0 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood Slackia 0 0 0.50329385 serum_phospholipids Genus 0.102 0.94 no up no no no no 14:0/18:2-PC+blood Sphingolipid signaling pathway 0 0 -0.452307692 serum_phospholipids kegg 0.102 NA no up no no no no 14:0/18:2-PC+blood Tuberculosis 0 0 -0.411538462 serum_phospholipids kegg 0.102 NA no up no no no dn 14:0/18:2-PC+blood TUDCA+stool 0 -0.62122474 0 serum_phospholipids stool_bileacids 0.102 0.241 no up no no no no 14:0/20:4-PC+blood 14:0-LPC+blood 0.472180451 0 0.55008547 serum_phospholipids serum_phospholipids 0.486 0.00689 no no no up up no 14:0/20:4-PC+blood 14:0/16:0-PC+blood 0.607518797 0 0 serum_phospholipids serum_phospholipids 0.486 0.0358 no no no no up no 14:0/20:4-PC+blood 14:0/18:2-PC+blood 0.822556391 0.759803922 0.828376068 serum_phospholipids serum_phospholipids 0.486 0.102 no no no no up no 14:0/20:4-PC+blood 14:0+blood 0 0 0.467350427 yes serum_phospholipids serum_fattyacid 0.486 0.00572 no no no up no dn 14:0/20:4-PC+blood AMPK signaling pathway 0 0 0.407692308 serum_phospholipids kegg 0.486 NA no no no no no no 14:0/20:4-PC+blood Biosynthesis of cofactors 0 0 0.407692308 serum_phospholipids kegg 0.486 NA no no no no no no 14:0/20:4-PC+blood Blautia 0 0 0.416812058 acetate-producing serum_phospholipids Genus 0.486 1.36E-05 no no no up dn dn 14:0/20:4-PC+blood Butyricimonas 0 0 -0.4409344 butyrate-producing serum_phospholipids Genus 0.486 0.17 no no no no no no 14:0/20:4-PC+blood cGMP-PKG signaling pathway 0 0 -0.458461538 serum_phospholipids kegg 0.486 NA no no no no no no 14:0/20:4-PC+blood Clostridium 0 0 -0.401576387 serum_phospholipids Genus 0.486 0.925 no no no no no no 14:0/20:4-PC+blood IL-17 signaling pathway 0 0 -0.423076923 serum_phospholipids kegg 0.486 NA no no no no no no 14:0/20:4-PC+blood Lipid and atherosclerosis 0 0 -0.419230769 serum_phospholipids kegg 0.486 NA no no no no no no 14:0/20:4-PC+blood Lysosome 0 0 -0.418461538 serum_phospholipids kegg 0.486 NA no no no no no no 14:0/20:4-PC+blood Neuroactive ligand-receptor interaction 0 0 -0.557692308 serum_phospholipids kegg 0.486 NA no no no up up up 14:0/20:4-PC+blood Non-alcoholic fatty liver disease 0 0 0.453846154 serum_phospholipids kegg 0.486 NA no no no no no no 14:0/20:4-PC+blood Proteasome 0 0 -0.42 serum_phospholipids kegg 0.486 NA no no no no no no 14:0+blood 11-HETE+blood 0 0 -0.515760294 yes serum_fattyacid serum_ARA 0.00572 0.464 up no dn no no no 14:0+blood 12-ketoDCA+blood 0 -0.533495442 0 yes serum_fattyacid serum_bileacids 0.00572 0.517 up no dn no no no 14:0+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0.626373626 0 0 yes serum_fattyacid stool_cometabolism 0.00572 0.33 up no dn no no no 14:0+blood Acetic acid+stool 0 -0.663636364 0 yes yes serum_fattyacid stool_scfa 0.00572 0.0656 up no dn dn no no 14:0+blood Adipocytokine signaling pathway -0.542105263 0 0 yes serum_fattyacid kegg 0.00572 NA up no dn no no no 14:0+blood Adlercreutzia 0 0 -0.462614034 yes serum_fattyacid Genus 0.00572 0.548 up no dn no no no 14:0+blood Amoebiasis 0 0 -0.407692308 yes serum_fattyacid kegg 0.00572 NA up no dn no no no 14:0+blood Bacteroides 0 -0.485294118 0 yes LPS-producing serum_fattyacid Genus 0.00572 0.000267 up no dn dn dn up 14:0+blood Central carbon metabolism in cancer 0.592982456 0 0 yes serum_fattyacid kegg 0.00572 NA up no dn no no no 14:0+blood cGMP-PKG signaling pathway 0 0 -0.443076923 yes serum_fattyacid kegg 0.00572 NA up no dn no no no 14:0+blood Focal adhesion 0 0 -0.409230769 yes serum_fattyacid kegg 0.00572 NA up no dn no up up 14:0+blood Glioma 0 0.505882353 0 yes serum_fattyacid kegg 0.00572 NA up no dn no no no 14:0+blood Leukocyte transendothelial migration 0 0 -0.418461538 yes serum_fattyacid kegg 0.00572 NA up no dn no no no 14:0+blood Phenylacetic acid+stool 0 -0.618181818 0 yes serum_fattyacid stool_cometabolism 0.00572 0.785 up no dn no no no 14:0+blood Porphyrin and chlorophyll metabolism 0 0 0.413076923 yes serum_fattyacid kegg 0.00572 NA up no dn no no no 14:0+blood Prevotella 0 0.556188795 0 yes acetate-producing serum_fattyacid Genus 0.00572 0.287 up no dn no no no 14:0+blood Rap1 signaling pathway 0 0 -0.405384615 yes serum_fattyacid kegg 0.00572 NA up no dn no no no 14:0+blood Sphingolipid signaling pathway 0 0 -0.461538462 yes serum_fattyacid kegg 0.00572 NA up no dn no no no 14:0+blood Th1 and Th2 cell differentiation -0.533333333 0 0 yes serum_fattyacid kegg 0.00572 NA up no dn no no no 14:0+blood Th17 cell differentiation -0.457894737 0 0 yes serum_fattyacid kegg 0.00572 NA up no dn no no no 14:1/18:2-PG+blood 14:0-LPC+blood 0.833082707 0.74754902 0.817435897 serum_phospholipids serum_phospholipids 0.00259 0.00689 no up up up up no 14:1/18:2-PG+blood 14:0/16:0-PC+blood 0.586466165 0.546568627 0.555555556 serum_phospholipids serum_phospholipids 0.00259 0.0358 no up up no up no 14:1/18:2-PG+blood 14:0/18:2-PC+blood 0.606015038 0.573529412 0.819487179 serum_phospholipids serum_phospholipids 0.00259 0.102 no up up no up no 14:1/18:2-PG+blood 14:0/20:4-PC+blood 0.472180451 0 0.706666667 serum_phospholipids serum_phospholipids 0.00259 0.486 no up up no no no 14:1/18:2-PG+blood 14:0+blood 0 0.556372549 0.680683761 yes serum_phospholipids serum_fattyacid 0.00259 0.00572 no up up up no dn 15-HETE+blood 12-ketoDCA+stool -0.693660595 0 0 serum_ARA stool_bileacids 0.819 0.505 no no no no no no 15-HETE+blood Amoebiasis 0.486744724 0 0 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Anaerostipes 0 0 0.478536028 butyrate-producing serum_ARA Genus 0.819 0.568 no no no no no no 15-HETE+blood Axon guidance 0 0 0.441028959 serum_ARA kegg 0.819 NA no no no no up up 15-HETE+blood Chemokine signaling pathway 0.463734973 0 0 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Gastric acid secretion 0.460195012 0 0 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Human papillomavirus infection 0.469044916 0 0 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Influenza A 0.545154091 0 0 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Legionellosis -0.527454282 0 0 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Leishmaniasis -0.470814896 0 0 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Leukocyte transendothelial migration 0.571703803 0 0 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Parabacteroides 0 0 -0.465442864 serum_ARA Genus 0.819 4.19E-05 no no no no up up 15-HETE+blood Phospholipase D signaling pathway 0.513294436 0 0 serum_ARA kegg 0.819 NA no no no no up up 15-HETE+blood Rap1 signaling pathway 0.532764225 0 0 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Regulation of actin cytoskeleton 0 0 0.40857736 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood RNA transport -0.492054666 0 0 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Ruminococcus 0 0 -0.404691701 serum_ARA Genus 0.819 0.0679 no no no no no dn 15-HETE+blood Slackia 0 0 -0.44060653 serum_ARA Genus 0.819 0.94 no no no no no no 15-HETE+blood Spliceosome -0.465504954 0 0 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Th1 and Th2 cell differentiation 0 0 -0.417960955 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Th17 cell differentiation 0 0 -0.415615056 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Thyroid hormone signaling pathway 0.492054666 0 0 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Viral carcinogenesis 0.523914321 0 0 serum_ARA kegg 0.819 NA no no no no no no 15-HETE+blood Yersinia infection 0.504444532 0 0 serum_ARA kegg 0.819 NA no no no no no no 16:0-LPC+blood 11-HETE+blood -0.479482077 0 0 serum_phospholipids serum_ARA 0.00456 0.464 up up no no no no 16:0-LPC+blood 14:0-LPC+blood 0 0 0.563760684 serum_phospholipids serum_phospholipids 0.00456 0.00689 up up no up up no 16:0-LPC+blood 14:0/18:0-PC+blood -0.494736842 0 0 serum_phospholipids serum_phospholipids 0.00456 0.00289 up up no up up no 16:0-LPC+blood 14:1/18:2-PG+blood 0 0 0.488547009 serum_phospholipids serum_phospholipids 0.00456 0.00259 up up no no up up 16:0-LPC+blood ACA+stool 0 0 0.534643732 serum_phospholipids stool_bileacids 0.00456 0.417 up up no no no no 16:0-LPC+blood Adipocytokine signaling pathway -0.459649123 0 0 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Amphetamine addiction 0.529824561 0 0 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Butyricicoccus -0.451705707 0 0 butyrate-producing serum_phospholipids Genus 0.00456 0.852 up up no no no no 16:0-LPC+blood Butyricimonas 0.469123886 0 0 butyrate-producing serum_phospholipids Genus 0.00456 0.17 up up no no no no 16:0-LPC+blood Calcium signaling pathway 0 0 0.43 serum_phospholipids kegg 0.00456 NA up up no no up up 16:0-LPC+blood Carbon metabolism 0 0 -0.547692308 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Cell cycle 0.464912281 0 0 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Chemical carcinogenesis - receptor activation 0.475438596 0 0 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Cortisol synthesis and secretion 0 0 0.437692308 serum_phospholipids kegg 0.00456 NA up up no no no up 16:0-LPC+blood Dorea -0.464661654 0 0 serum_phospholipids Genus 0.00456 0.00362 up up no up no dn 16:0-LPC+blood Endocrine and other factor-regulated calcium reabsorption 0 0 0.429230769 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Endocrine resistance 0.463157895 0 0 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Estrogen signaling pathway 0.557894737 0 0 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Fusobacterium 0 0.48659424 0 serum_phospholipids Genus 0.00456 0.628 up up no no no no 16:0-LPC+blood Glucagon signaling pathway 0.512280702 0 0 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Glycolysis / Gluconeogenesis 0 0 -0.558461538 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood HDCA+stool 0 0 -0.458646617 serum_phospholipids stool_bileacids 0.00456 0.176 up up no no no no 16:0-LPC+blood Inflammatory mediator regulation of TRP channels 0.570175439 0 0 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Insulin secretion 0 0 0.437692308 yes serum_phospholipids kegg 0.00456 NA up up no no up up 16:0-LPC+blood Leukocyte transendothelial migration 0 0 -0.420769231 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood MAPK signaling pathway 0 0 -0.488461538 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Morphine addiction 0 0 0.426923077 serum_phospholipids kegg 0.00456 NA up up no no up up 16:0-LPC+blood Parkinson disease 0 0 0.542307692 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Pathways of neurodegeneration - multiple diseases 0 0 0.560769231 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Ribosome biogenesis in eukaryotes 0.50877193 0 0 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Roseburia 0 0 -0.515213675 butyrate-producing serum_phospholipids Genus 0.00456 0.495 up up no no no no 16:0-LPC+blood Salmonella infection 0 0 -0.43 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPC+blood Transcriptional misregulation in cancer 0 0 0.450769231 serum_phospholipids kegg 0.00456 NA up up no no no no 16:0-LPE+blood 13-HODE+blood -0.490225564 0 0 serum_phospholipids serum_ARA 0.0711 0.32 up up no no no no 16:0-LPE+blood 14:0/18:0-PC+blood 0 0 0.535042735 serum_phospholipids serum_phospholipids 0.0711 0.00289 up up no up up no 16:0-LPE+blood 14:0/20:4-PC+blood 0 -0.634803922 0 serum_phospholipids serum_phospholipids 0.0711 0.486 up up no no no no 16:0/16:0-PC+blood 14:0/16:0-PC+blood 0.454135338 0 0 serum_phospholipids serum_phospholipids 0.00079 0.0358 no up up no up no 16:0/16:0-PC+blood 16:0/14:0-PC+blood 0.568421053 0.573529412 0.790769231 serum_phospholipids serum_phospholipids 0.00079 0.0206 no up up no up up 16:0/16:0-PC+blood Adherens junction 0 0 -0.486923077 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Alistipes 0 -0.523605249 0 serum_phospholipids Genus 0.00079 0.0114 no up up no up no 16:0/16:0-PC+blood Alzheimer disease 0 0 -0.415384615 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood AMPK signaling pathway 0 -0.608823529 0 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Amyotrophic lateral sclerosis 0 0 -0.548461538 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.511538462 serum_phospholipids kegg 0.00079 NA no up up no up up 16:0/16:0-PC+blood Bacterial invasion of epithelial cells 0 0 -0.453076923 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Butyric acid+stool 0.554945055 0 0 yes serum_phospholipids stool_scfa 0.00079 0.102 no up up dn no no 16:0/16:0-PC+blood Cardiac muscle contraction 0 0 -0.428461538 serum_phospholipids kegg 0.00079 NA no up up no no up 16:0/16:0-PC+blood Chemical carcinogenesis - receptor activation 0 0 0.433076923 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Coprococcus 0 0.504901961 0 butyrate-producing serum_phospholipids Genus 0.00079 0.612 no up up no no no 16:0/16:0-PC+blood Diabetic cardiomyopathy 0 0 -0.426153846 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Focal adhesion 0 0 -0.46 serum_phospholipids kegg 0.00079 NA no up up no up up 16:0/16:0-PC+blood HCA+stool 0 0 -0.553383459 serum_phospholipids stool_bileacids 0.00079 0.155 no up up no no no 16:0/16:0-PC+blood Hepatocellular carcinoma 0 0 -0.483846154 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Hippo signaling pathway 0 0 -0.504615385 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Huntington disease 0 0 -0.487692308 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Hypertrophic cardiomyopathy 0 0 -0.496153846 serum_phospholipids kegg 0.00079 NA no up up no up up 16:0/16:0-PC+blood Inflammatory mediator regulation of TRP channels 0 -0.523529412 0 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Influenza A 0 0.567647059 0 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood L-Phenylalanine+stool 0 0 0.485714286 serum_phospholipids stool_cometabolism 0.00079 0.398 no up up no no no 16:0/16:0-PC+blood L-Tyrosine+stool 0 0 0.457142857 serum_phospholipids stool_cometabolism 0.00079 0.44 no up up no no no 16:0/16:0-PC+blood Longevity regulating pathway 0 -0.520588235 0 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Mineral absorption -0.533333333 0 0 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Necroptosis -0.515789474 0 0 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood nutriCA+stool 0 0 -0.467669173 serum_phospholipids stool_bileacids 0.00079 0.481 no up up no no no 16:0/16:0-PC+blood Prevotella -0.454871493 0 0 acetate-producing serum_phospholipids Genus 0.00079 0.287 no up up no no no 16:0/16:0-PC+blood Prion disease 0 0 -0.476153846 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Progesterone-mediated oocyte maturation 0.478947368 0 0 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Propionic acid+stool 0 -0.645454545 0 yes serum_phospholipids stool_scfa 0.00079 0.0436 no up up dn no up 16:0/16:0-PC+blood Regulation of actin cytoskeleton 0 0 -0.462307692 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Salmonella infection 0 0.511764706 0 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Th1 and Th2 cell differentiation 0 0.617647059 0 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Th17 cell differentiation 0 0.514705882 0 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Thyroid hormone signaling pathway 0 0 -0.464615385 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood Tight junction 0 0 -0.469230769 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PC+blood UDCA+stool 0 0 -0.553383459 serum_phospholipids stool_bileacids 0.00079 0.266 no up up no no no 16:0/16:0-PC+blood Viral myocarditis 0 0.517647059 0 serum_phospholipids kegg 0.00079 NA no up up no no no 16:0/16:0-PI+blood 14:0-LPC+blood 0 0 0.763418803 serum_phospholipids serum_phospholipids 0.358 0.00689 no no no up up no 16:0/16:0-PI+blood 14:0/16:0-PC+blood 0 0 0.748376068 serum_phospholipids serum_phospholipids 0.358 0.0358 no no no no up no 16:0/16:0-PI+blood 14:0/18:0-PC+blood 0 0.740196078 0.541880342 serum_phospholipids serum_phospholipids 0.358 0.00289 no no no up up no 16:0/16:0-PI+blood 14:0/18:2-PC+blood 0 0 0.635555556 serum_phospholipids serum_phospholipids 0.358 0.102 no no no no up no 16:0/16:0-PI+blood 14:0/20:4-PC+blood 0 0 0.410598291 serum_phospholipids serum_phospholipids 0.358 0.486 no no no no no no 16:0/16:0-PI+blood 14:0+blood 0 0 0.616410256 yes serum_phospholipids serum_fattyacid 0.358 0.00572 no no no up no dn 16:0/16:0-PI+blood 14:1/18:2-PG+blood 0 0 0.692991453 serum_phospholipids serum_phospholipids 0.358 0.00259 no no no no up up 16:0/16:0-PI+blood 15-HETE+blood -0.500014349 0 0 serum_phospholipids serum_ARA 0.358 0.819 no no no no no no 16:0/16:0-PI+blood 16:0-LPE+blood 0.526315789 0 0 serum_phospholipids serum_phospholipids 0.358 0.0711 no no no up up no 16:0/16:1-PC+blood 11-HETE+blood 0 0.757121734 0 serum_phospholipids serum_ARA 0.00283 0.464 up up no no no no 16:0/16:1-PC+blood 12-ketoDCA+stool 0.626373626 0 0 serum_phospholipids stool_bileacids 0.00283 0.505 up up no no no no 16:0/16:1-PC+blood 14:0-LPC+blood 0 0 0.556923077 serum_phospholipids serum_phospholipids 0.00283 0.00689 up up no up up no 16:0/16:1-PC+blood 14:0/16:0-PC+blood 0.598496241 0.799019608 0.810598291 serum_phospholipids serum_phospholipids 0.00283 0.0358 up up no no up no 16:0/16:1-PC+blood 14:0/18:0-PC+blood 0.971428571 0.992647059 0.991111111 serum_phospholipids serum_phospholipids 0.00283 0.00289 up up no up up no 16:0/16:1-PC+blood 14:0/18:2-PC+blood 0 0 0.438632479 serum_phospholipids serum_phospholipids 0.00283 0.102 up up no no up no 16:0/16:1-PC+blood 14:0+blood 0 0 0.548034188 yes serum_phospholipids serum_fattyacid 0.00283 0.00572 up up no up no dn 16:0/16:1-PC+blood 14:1/18:2-PG+blood 0 0 0.402393162 serum_phospholipids serum_phospholipids 0.00283 0.00259 up up no no up up 16:0/16:1-PC+blood 16:0-LPC+blood -0.457142857 0 0 serum_phospholipids serum_phospholipids 0.00283 0.00456 up up no up up no 16:0/16:1-PC+blood 16:0-LPE+blood 0 0 0.542564103 serum_phospholipids serum_phospholipids 0.00283 0.0711 up up no up up no 16:0/16:1-PC+blood 16:0/16:0-PI+blood 0 0.725490196 0.576068376 serum_phospholipids serum_phospholipids 0.00283 0.358 up up no no no no 16:0/16:1-PC+blood 16:0+blood 0 0 0.605470085 yes serum_phospholipids serum_fattyacid 0.00283 0.00876 up up no up no no 16:0/16:1-PC+blood Axon guidance 0 0.547058824 0 serum_phospholipids kegg 0.00283 NA up up no no up up 16:0/16:1-PC+blood Bacterial invasion of epithelial cells 0 0 -0.420769231 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Butyricimonas -0.45101735 0 0 butyrate-producing serum_phospholipids Genus 0.00283 0.17 up up no no no no 16:0/16:1-PC+blood cAMP signaling pathway -0.492982456 0 0 yes serum_phospholipids kegg 0.00283 NA up up no no up up 16:0/16:1-PC+blood cGMP-PKG signaling pathway -0.533333333 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Collinsella 0.481928257 0 0 serum_phospholipids Genus 0.00283 0.128 up up no no no no 16:0/16:1-PC+blood Dorea 0.547368421 0 0 serum_phospholipids Genus 0.00283 0.00362 up up no up no dn 16:0/16:1-PC+blood Epstein-Barr virus infection 0 0 0.400769231 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Fc epsilon RI signaling pathway -0.60877193 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood FoxO signaling pathway -0.543859649 0 -0.498461538 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood GCDCA+stool 0 0.690909091 0 yes serum_phospholipids stool_bileacids 0.00283 0.0471 up up no no dn no 16:0/16:1-PC+blood Gemmiger 0.538345865 0 0 butyrate-producing serum_phospholipids Genus 0.00283 0.595 up up no no no no 16:0/16:1-PC+blood Glutathione metabolism 0.58245614 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood "Glycine, serine and threonine metabolism" 0.468421053 0 0 serum_phospholipids kegg 0.00283 NA up up no no up no 16:0/16:1-PC+blood Glycolysis / Gluconeogenesis 0.514035088 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Hepatitis C -0.543859649 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Human cytomegalovirus infection 0 0 0.403846154 serum_phospholipids kegg 0.00283 NA up up no no no dn 16:0/16:1-PC+blood Intestinal immune network for IgA production 0 0.511764706 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood L-Phenylalanine+stool -0.747252747 0 0 serum_phospholipids stool_cometabolism 0.00283 0.398 up up no no no no 16:0/16:1-PC+blood L-Tryptophan+stool -0.593406593 0 0 serum_phospholipids stool_cometabolism 0.00283 0.557 up up no no no no 16:0/16:1-PC+blood L-Tyrosine+stool -0.582417582 0 0 serum_phospholipids stool_cometabolism 0.00283 0.44 up up no no no no 16:0/16:1-PC+blood Legionellosis 0.607017544 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Leishmaniasis 0.594736842 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Leukocyte transendothelial migration 0 0 -0.419230769 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood MAPK signaling pathway 0 -0.664705882 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Olfactory transduction -0.510526316 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Pancreatic cancer -0.622807018 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Pathways in cancer -0.526315789 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Phenylacetic acid+stool 0 -0.636363636 0 serum_phospholipids stool_cometabolism 0.00283 0.785 up up no no no no 16:0/16:1-PC+blood Phospholipase D signaling pathway -0.464912281 0 0 serum_phospholipids kegg 0.00283 NA up up no no up up 16:0/16:1-PC+blood Primary immunodeficiency 0 0 -0.456153846 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Prolactin signaling pathway -0.528070175 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Purine metabolism 0.59122807 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Rheumatoid arthritis 0.456140351 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Roseburia 0 0.570202437 0 butyrate-producing serum_phospholipids Genus 0.00283 0.495 up up no no no no 16:0/16:1-PC+blood Salmonella infection 0 0 -0.415384615 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Sphingolipid signaling pathway -0.521052632 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood VEGF signaling pathway -0.559649123 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PC+blood Yersinia infection -0.464912281 0 0 serum_phospholipids kegg 0.00283 NA up up no no no no 16:0/16:1-PI+blood 11-HETE+blood 0 0.645274205 0 serum_phospholipids serum_ARA 0.262 0.464 no no no no no no 16:0/16:1-PI+blood 12-ketoDCA+blood 0.545287397 0 0 serum_phospholipids serum_bileacids 0.262 0.517 no no no no no no 16:0/16:1-PI+blood 14:0-LPC+blood 0.676691729 0 0.597264957 serum_phospholipids serum_phospholipids 0.262 0.00689 no no no up up no 16:0/16:1-PI+blood 14:0/16:0-PC+blood 0 0.573529412 0.631452991 serum_phospholipids serum_phospholipids 0.262 0.0358 no no no no up no 16:0/16:1-PI+blood 14:0/18:0-PC+blood 0 0.81372549 0.757948718 serum_phospholipids serum_phospholipids 0.262 0.00289 no no no up up no 16:0/16:1-PI+blood 14:1/18:2-PG+blood 0 0 0.424273504 serum_phospholipids serum_phospholipids 0.262 0.00259 no no no no up up 16:0/16:1-PI+blood 16:0-LPC+blood 0 0 0.434529915 serum_phospholipids serum_phospholipids 0.262 0.00456 no no no up up no 16:0/16:1-PI+blood 16:0-LPE+blood 0 0 0.541880342 serum_phospholipids serum_phospholipids 0.262 0.0711 no no no up up no 16:0/16:1-PI+blood 16:0/16:0-PI+blood 0.684210526 0.774509804 0.753846154 serum_phospholipids serum_phospholipids 0.262 0.358 no no no no no no 16:0/16:1-PI+blood 16:0/16:1-PC+blood 0 0.828431373 0.771623932 serum_phospholipids serum_phospholipids 0.262 0.00283 no no no up up no 16:0/16:1-PI+blood 16:0+blood 0 0 0.491282051 yes serum_phospholipids serum_fattyacid 0.262 0.00876 no no no up no no 16:0/18:0-PC+blood 16:0-LPE+blood 0 0 -0.416068376 serum_phospholipids serum_phospholipids 0.521 0.0711 no no no up up no 16:0/18:0-PC+blood 16:0/14:0-PC+blood 0 0 0.416068376 serum_phospholipids serum_phospholipids 0.521 0.0206 no no no no up up 16:0/18:0-PC+blood 16:0/16:0-PC+blood 0.663157895 0 0.450940171 serum_phospholipids serum_phospholipids 0.521 0.00079 no no no no up up 16:0/18:0-PC+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.603007519 serum_phospholipids stool_cometabolism 0.521 0.33 no no no no no no 16:0/18:0-PC+blood Adlercreutzia 0 0 0.489187164 serum_phospholipids Genus 0.521 0.548 no no no no no no 16:0/18:0-PC+blood Allograft rejection 0 0 -0.410769231 serum_phospholipids kegg 0.521 NA no no no no no no 16:0/18:0-PC+blood Autoimmune thyroid disease 0 0 -0.410769231 serum_phospholipids kegg 0.521 NA no no no no no no 16:0/18:0-PC+blood Graft-versus-host disease 0 0 -0.411538462 serum_phospholipids kegg 0.521 NA no no no no no no 16:0/18:0-PC+blood L-Phenylalanine+stool 0 0 0.476691729 serum_phospholipids stool_cometabolism 0.521 0.398 no no no no no no 16:0/18:0-PC+blood L-Tyrosine+stool 0 0 0.503759398 serum_phospholipids stool_cometabolism 0.521 0.44 no no no no no no 16:0/18:0-PC+blood Methanobrevibacter 0 0 0.537763232 serum_phospholipids Genus 0.521 0.629 no no no no no no 16:0/18:0-PC+blood Necroptosis -0.468421053 0 0 serum_phospholipids kegg 0.521 NA no no no no no no 16:0/18:0-PC+blood UDCA+stool 0 0 -0.458646617 serum_phospholipids stool_bileacids 0.521 0.266 no no no no no no 16:0/18:0-PC+blood Viral myocarditis 0 0 -0.460769231 serum_phospholipids kegg 0.521 NA no no no no no no 16:0/18:0-PS+blood 12-HEPE+blood -0.587799063 0 0 serum_phospholipids serum_ARA 0.377 0.312 no no no no no no 16:0/18:0-PS+blood 12-ketoDCA+blood 0 -0.602652259 0 serum_phospholipids serum_bileacids 0.377 0.517 no no no no no no 16:0/18:0-PS+blood 16:0-LPE+blood 0.448120301 0 0 serum_phospholipids serum_phospholipids 0.377 0.0711 no no no up up no 16:0/18:0-PS+blood 16:0/14:0-PC+blood 0 0 -0.540512821 serum_phospholipids serum_phospholipids 0.377 0.0206 no no no no up up 16:0/18:0-PS+blood Acetic acid+stool 0 -0.627272727 0 yes serum_phospholipids stool_scfa 0.377 0.0656 no no no dn no no 16:0/18:0-PS+blood Adipocytokine signaling pathway -0.540350877 -0.55 0 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood Calcium signaling pathway 0 -0.617647059 0 serum_phospholipids kegg 0.377 NA no no no no up up 16:0/18:0-PS+blood Carbon metabolism 0.461403509 0 0 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood Cytosolic DNA-sensing pathway 0 -0.526470588 0 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood DCA+stool 0 0 0.460150376 serum_phospholipids stool_bileacids 0.377 0.195 no no no no no no 16:0/18:0-PS+blood GCA+stool 0.598901099 0 0 serum_phospholipids stool_bileacids 0.377 0.0809 no no no no no no 16:0/18:0-PS+blood Glycolysis / Gluconeogenesis 0.492982456 0 0 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood Human cytomegalovirus infection 0 0 0.440769231 serum_phospholipids kegg 0.377 NA no no no no no dn 16:0/18:0-PS+blood Human immunodeficiency virus 1 infection 0 0 0.408461538 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood Human T-cell leukemia virus 1 infection 0 0 0.403076923 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood Intestinal immune network for IgA production -0.577192982 0 0 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood Kaposi sarcoma-associated herpesvirus infection -0.624561404 0 0 serum_phospholipids kegg 0.377 NA no no no no no dn 16:0/18:0-PS+blood Longevity regulating pathway - multiple species 0.612280702 0.508823529 0 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood Mitophagy - animal 0 -0.617647059 0 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood Necroptosis -0.464912281 0 0 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood Primary immunodeficiency 0.559649123 0 0 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood Propionic acid+stool 0 0 0.467669173 yes serum_phospholipids stool_scfa 0.377 0.0436 no no no dn no up 16:0/18:0-PS+blood Relaxin signaling pathway -0.50877193 0 0 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood Roseburia 0 0 0.446153846 butyrate-producing serum_phospholipids Genus 0.377 0.495 no no no no no no 16:0/18:0-PS+blood Shigellosis 0 -0.591176471 0 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood Th1 and Th2 cell differentiation -0.589473684 0 0 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood Th17 cell differentiation -0.636842105 0 0 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:0-PS+blood Ubiquitin mediated proteolysis 0 -0.526470588 0 serum_phospholipids kegg 0.377 NA no no no no no no 16:0/18:1-PC+blood 14:0/18:0-PC+blood 0 0 0.550769231 serum_phospholipids serum_phospholipids 6.15E-07 0.00289 up up up up up no 16:0/18:1-PC+blood 14:0/20:4-PC+blood 0 0 -0.418119658 serum_phospholipids serum_phospholipids 6.15E-07 0.486 up up up no no no 16:0/18:1-PC+blood 16:0/14:0-PC+blood 0.664661654 0.644607843 0 serum_phospholipids serum_phospholipids 6.15E-07 0.0206 up up up no up up 16:0/18:1-PC+blood 16:0/16:0-PC+blood 0.581954887 0.708333333 0.425641026 serum_phospholipids serum_phospholipids 6.15E-07 0.00079 up up up no up up 16:0/18:1-PC+blood 16:0/16:0-PI+blood -0.613533835 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.358 up up up no no no 16:0/18:1-PC+blood 16:0/16:1-PC+blood 0 0 0.525470085 serum_phospholipids serum_phospholipids 6.15E-07 0.00283 up up up up up no 16:0/18:1-PC+blood 16:0/16:1-PI+blood -0.685714286 0 0 serum_phospholipids serum_phospholipids 6.15E-07 0.262 up up up no no no 16:0/18:1-PC+blood 16:0+blood 0 0 0.468717949 yes serum_phospholipids serum_fattyacid 6.15E-07 0.00876 up up up up no no 16:0/18:1-PC+blood Adherens junction 0 0 -0.459230769 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Adrenergic signaling in cardiomyocytes 0 -0.611764706 0 serum_phospholipids kegg 6.15E-07 NA up up up no no up 16:0/18:1-PC+blood Alistipes 0.529815093 0 0 serum_phospholipids Genus 6.15E-07 0.0114 up up up no up no 16:0/18:1-PC+blood Allograft rejection 0 0.538235294 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood AMPK signaling pathway 0 -0.691176471 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Amyotrophic lateral sclerosis 0 0 -0.403846154 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Arginine and proline metabolism 0 0 0.476153846 serum_phospholipids kegg 6.15E-07 NA up up up no up no 16:0/18:1-PC+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.503076923 serum_phospholipids kegg 6.15E-07 NA up up up no up up 16:0/18:1-PC+blood Autoimmune thyroid disease 0 0.538235294 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood CDCA+stool 0 0.609090909 0 serum_phospholipids stool_bileacids 6.15E-07 0.663 up up up no no no 16:0/18:1-PC+blood Central carbon metabolism in cancer 0 -0.644117647 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Cytokine-cytokine receptor interaction 0 0 -0.407692308 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Dilated cardiomyopathy 0 0 -0.566923077 serum_phospholipids kegg 6.15E-07 NA up up up no up up 16:0/18:1-PC+blood EGFR tyrosine kinase inhibitor resistance 0 0 0.465384615 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Epstein-Barr virus infection 0 0 0.433846154 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Faecalibacterium 0 0 -0.404171659 butyrate-producing serum_phospholipids Genus 6.15E-07 0.0039 up up up no dn dn 16:0/18:1-PC+blood Focal adhesion 0 0 -0.466153846 serum_phospholipids kegg 6.15E-07 NA up up up no up up 16:0/18:1-PC+blood Fusobacterium 0 -0.676670116 0 serum_phospholipids Genus 6.15E-07 0.628 up up up no no no 16:0/18:1-PC+blood Gap junction 0 0 -0.44 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Gastric acid secretion 0 0 -0.508461538 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood GCA+stool 0 0 0.518796992 serum_phospholipids stool_bileacids 6.15E-07 0.0809 up up up no no no 16:0/18:1-PC+blood GCDCA+stool 0 0.627272727 0 yes serum_phospholipids stool_bileacids 6.15E-07 0.0471 up up up no dn no 16:0/18:1-PC+blood GDCA+stool 0 0.646926508 0 serum_phospholipids stool_bileacids 6.15E-07 0.656 up up up no no no 16:0/18:1-PC+blood "Glycine, serine and threonine metabolism" 0 -0.597058824 0 serum_phospholipids kegg 6.15E-07 NA up up up no up no 16:0/18:1-PC+blood GnRH signaling pathway 0 -0.558823529 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Graft-versus-host disease 0 0.538235294 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood HDCA+stool 0.653846154 0 0 serum_phospholipids stool_bileacids 6.15E-07 0.176 up up up no no no 16:0/18:1-PC+blood Hepatocellular carcinoma 0 0 -0.503076923 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood HIF-1 signaling pathway 0 0 0.500769231 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Hippo signaling pathway 0 0 -0.513076923 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Human immunodeficiency virus 1 infection 0 0 0.433076923 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Hypertrophic cardiomyopathy 0 0 -0.52 serum_phospholipids kegg 6.15E-07 NA up up up no up up 16:0/18:1-PC+blood Influenza A 0.470175439 0 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Insulin signaling pathway 0 0 0.426153846 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood LCA+stool 0.56043956 0 0 serum_phospholipids stool_bileacids 6.15E-07 0.314 up up up no no no 16:0/18:1-PC+blood mTOR signaling pathway 0 -0.502941176 0.57 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood p53 signaling pathway -0.478947368 0 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Parabacteroides 0.478195489 0 0 serum_phospholipids Genus 6.15E-07 4.19E-05 up up up no up up 16:0/18:1-PC+blood "Parathyroid hormone synthesis, secretion and action" 0 -0.532352941 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Phenylacetic acid+stool 0 -0.636363636 0 serum_phospholipids stool_cometabolism 6.15E-07 0.785 up up up no no no 16:0/18:1-PC+blood Platelet activation 0 0 -0.513846154 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Proteasome 0 0 0.574615385 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Rap1 signaling pathway 0 0 -0.500769231 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Renal cell carcinoma 0 -0.502941176 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Rheumatoid arthritis 0.484210526 0 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Salmonella infection 0 0.570588235 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood TCA+stool -0.773040621 0 0.463157895 serum_phospholipids stool_bileacids 6.15E-07 0.458 up up up no no no 16:0/18:1-PC+blood Th1 and Th2 cell differentiation 0 0.544117647 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Thyroid hormone signaling pathway 0 0 -0.529230769 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Toxoplasmosis 0 0.579411765 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Type I diabetes mellitus 0 0.538235294 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Vibrio cholerae infection 0 0 -0.446153846 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PC+blood Viral myocarditis 0 0.561764706 0 serum_phospholipids kegg 6.15E-07 NA up up up no no no 16:0/18:1-PE+blood 11-HETE+blood 0 0.696896142 0 serum_phospholipids serum_ARA 0.000107 0.464 up up no no no no 16:0/18:1-PE+blood 12-ketoDCA+blood 0 -0.592772713 0 serum_phospholipids serum_bileacids 0.000107 0.517 up up no no no no 16:0/18:1-PE+blood "12,13-EPOME+blood" 0 0.48728047 0 serum_phospholipids serum_ARA 0.000107 0.901 up up no no no no 16:0/18:1-PE+blood 13-HODE+blood -0.45112782 0 0 serum_phospholipids serum_ARA 0.000107 0.32 up up no no no no 16:0/18:1-PE+blood 14:0/18:0-PC+blood 0 0.732843137 0 serum_phospholipids serum_phospholipids 0.000107 0.00289 up up no up up no 16:0/18:1-PE+blood 14:0/20:4-PC+blood 0 -0.529411765 0 serum_phospholipids serum_phospholipids 0.000107 0.486 up up no no no no 16:0/18:1-PE+blood 15-HETE+blood -0.527287859 0 0 serum_phospholipids serum_ARA 0.000107 0.819 up up no no no no 16:0/18:1-PE+blood 16:0-LPE+blood 0.603007519 0 0.535726496 serum_phospholipids serum_phospholipids 0.000107 0.0711 up up no up up no 16:0/18:1-PE+blood 16:0/16:0-PC+blood -0.466165414 0 0 serum_phospholipids serum_phospholipids 0.000107 0.00079 up up no no up up 16:0/18:1-PE+blood 16:0/16:0-PI+blood 0.705263158 0.566176471 0 serum_phospholipids serum_phospholipids 0.000107 0.358 up up no no no no 16:0/18:1-PE+blood 16:0/16:1-PC+blood 0 0.732843137 0.405128205 serum_phospholipids serum_phospholipids 0.000107 0.00283 up up no up up no 16:0/18:1-PE+blood 16:0/16:1-PI+blood 0.463157895 0.566176471 0.445470085 serum_phospholipids serum_phospholipids 0.000107 0.262 up up no no no no 16:0/18:1-PE+blood 16:0/18:0-PC+blood 0 0 -0.498803419 serum_phospholipids serum_phospholipids 0.000107 0.521 up up no no no no 16:0/18:1-PE+blood 16:0/18:0-PS+blood 0.569924812 0 0.497435897 serum_phospholipids serum_phospholipids 0.000107 0.377 up up no no no no 16:0/18:1-PE+blood 16:0/18:1-PC+blood -0.566917293 0 0 serum_phospholipids serum_phospholipids 0.000107 6.15E-07 up up no up up up 16:0/18:2-PC+blood 13-HODE+blood 0 0.568627451 0 serum_phospholipids serum_ARA 3.24E-06 0.32 no up up no no no 16:0/18:2-PC+blood 14:0/18:2-PC+blood 0 0 -0.446153846 serum_phospholipids serum_phospholipids 3.24E-06 0.102 no up up no up no 16:0/18:2-PC+blood 14:0/20:4-PC+blood 0 0 -0.616410256 serum_phospholipids serum_phospholipids 3.24E-06 0.486 no up up no no no 16:0/18:2-PC+blood 14:1/18:2-PG+blood 0 0 -0.439316239 serum_phospholipids serum_phospholipids 3.24E-06 0.00259 no up up no up up 16:0/18:2-PC+blood 16:0-LPE+blood -0.512781955 0 0 serum_phospholipids serum_phospholipids 3.24E-06 0.0711 no up up up up no 16:0/18:2-PC+blood 16:0/14:0-PC+blood 0.604511278 0.718137255 0.723076923 serum_phospholipids serum_phospholipids 3.24E-06 0.0206 no up up no up up 16:0/18:2-PC+blood 16:0/16:0-PC+blood 0.536842105 0.656862745 0.550769231 serum_phospholipids serum_phospholipids 3.24E-06 0.00079 no up up no up up 16:0/18:2-PC+blood 16:0/16:0-PI+blood -0.521804511 0 0 serum_phospholipids serum_phospholipids 3.24E-06 0.358 no up up no no no 16:0/18:2-PC+blood 16:0/16:1-PI+blood -0.563909774 0 0 serum_phospholipids serum_phospholipids 3.24E-06 0.262 no up up no no no 16:0/18:2-PC+blood 16:0/18:1-PC+blood 0.869172932 0.914215686 0.714188034 serum_phospholipids serum_phospholipids 3.24E-06 6.15E-07 no up up up up up 16:0/18:2-PC+blood 16:0/18:1-PE+blood -0.654135338 0 0 serum_phospholipids serum_phospholipids 3.24E-06 0.000107 no up up up up no 16:0/18:2-PC+blood Adherens junction 0 0 -0.404615385 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Adrenergic signaling in cardiomyocytes 0 -0.623529412 0 serum_phospholipids kegg 3.24E-06 NA no up up no no up 16:0/18:2-PC+blood Aldosterone synthesis and secretion 0 0 -0.415384615 serum_phospholipids kegg 3.24E-06 NA no up up no up up 16:0/18:2-PC+blood Alistipes 0.458871192 0 0 serum_phospholipids Genus 3.24E-06 0.0114 no up up no up no 16:0/18:2-PC+blood Alzheimer disease 0 0 -0.518461538 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood AMPK signaling pathway 0 -0.638235294 0 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Amyotrophic lateral sclerosis 0 0 -0.593076923 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Blautia 0 0 -0.407206513 acetate-producing serum_phospholipids Genus 3.24E-06 1.36E-05 no up up up dn dn 16:0/18:2-PC+blood Cardiac muscle contraction 0 0 -0.556153846 serum_phospholipids kegg 3.24E-06 NA no up up no no up 16:0/18:2-PC+blood Central carbon metabolism in cancer 0 -0.726470588 0 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Diabetic cardiomyopathy 0 0 -0.510769231 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Dilated cardiomyopathy 0 0 -0.507692308 serum_phospholipids kegg 3.24E-06 NA no up up no up up 16:0/18:2-PC+blood EGFR tyrosine kinase inhibitor resistance 0 -0.558823529 0 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Endocrine and other factor-regulated calcium reabsorption 0 0 -0.419230769 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Faecalibacterium 0 0 -0.408958802 butyrate-producing serum_phospholipids Genus 3.24E-06 0.0039 no up up no dn dn 16:0/18:2-PC+blood Focal adhesion 0 0 -0.424615385 serum_phospholipids kegg 3.24E-06 NA no up up no up up 16:0/18:2-PC+blood Fusobacterium 0 -0.599119159 0 serum_phospholipids Genus 3.24E-06 0.628 no up up no no no 16:0/18:2-PC+blood Gap junction 0 0 -0.481538462 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Gastric acid secretion 0 0 -0.453076923 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood GCDCA+stool 0 0.609090909 0 yes serum_phospholipids stool_bileacids 3.24E-06 0.0471 no up up no dn no 16:0/18:2-PC+blood GDCA+stool -0.598901099 0 0 serum_phospholipids stool_bileacids 3.24E-06 0.656 no up up no no no 16:0/18:2-PC+blood "Glycine, serine and threonine metabolism" 0 -0.508823529 0 serum_phospholipids kegg 3.24E-06 NA no up up no up no 16:0/18:2-PC+blood Hepatocellular carcinoma 0 0 -0.406153846 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Hippo signaling pathway 0 0 -0.472307692 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Huntington disease 0 0 -0.503076923 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood IL-17 signaling pathway 0 0 0.476153846 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Inflammatory mediator regulation of TRP channels 0 -0.526470588 -0.45 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Lachnospira 0 0 0.415411568 butyrate-producing serum_phospholipids Genus 3.24E-06 0.279 no up up no no no 16:0/18:2-PC+blood LCA+stool 0.582417582 0 0 serum_phospholipids stool_bileacids 3.24E-06 0.314 no up up no no no 16:0/18:2-PC+blood mRNA surveillance pathway 0 -0.523529412 0 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood mTOR signaling pathway 0 -0.588235294 0.405384615 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Non-alcoholic fatty liver disease 0 0 -0.596153846 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Oxidative phosphorylation 0 0 -0.489230769 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Pancreatic secretion 0 0 -0.474615385 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood "Parathyroid hormone synthesis, secretion and action" 0 -0.520588235 0 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Peroxisome 0 0 0.421538462 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Phenylacetic acid+stool 0 -0.627272727 0 serum_phospholipids stool_cometabolism 3.24E-06 0.785 no up up no no no 16:0/18:2-PC+blood Platelet activation 0 0 -0.427692308 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Prion disease 0 0 -0.51 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Proteasome 0 0 0.544615385 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Renal cell carcinoma 0 -0.5 0 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Retrograde endocannabinoid signaling 0 0 -0.411538462 serum_phospholipids kegg 3.24E-06 NA no up up no no up 16:0/18:2-PC+blood RNA transport 0 -0.564705882 0 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Ruminococcus 0 0 -0.422411323 serum_phospholipids Genus 3.24E-06 0.0679 no up up no no dn 16:0/18:2-PC+blood Salmonella infection 0 0.505882353 0 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood TCA+stool -0.629986841 0 0 serum_phospholipids stool_bileacids 3.24E-06 0.458 no up up no no no 16:0/18:2-PC+blood Th1 and Th2 cell differentiation 0 0.532352941 0 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Thermogenesis 0 0 -0.429230769 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Thyroid hormone signaling pathway 0 0 -0.527692308 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Toxoplasmosis 0 0.561764706 0 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood UDCA+stool 0 0 -0.445112782 serum_phospholipids stool_bileacids 3.24E-06 0.266 no up up no no no 16:0/18:2-PC+blood Vasopressin-regulated water reabsorption 0 0 -0.471538462 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PC+blood Viral myocarditis 0 0.5 0 serum_phospholipids kegg 3.24E-06 NA no up up no no no 16:0/18:2-PI+blood 11-HETE+blood -0.510881788 0 0 serum_phospholipids serum_ARA 0.269 0.464 no no no no no no 16:0/18:2-PI+blood "12,13-EPOME+blood" 0 0.496049013 0 serum_phospholipids serum_ARA 0.269 0.901 no no no no no no 16:0/18:2-PI+blood 14:0-LPC+blood 0.672180451 0.482843137 0.66017094 serum_phospholipids serum_phospholipids 0.269 0.00689 no no no up up no 16:0/18:2-PI+blood 14:0/16:0-PC+blood 0 0 0.623931624 serum_phospholipids serum_phospholipids 0.269 0.0358 no no no no up no 16:0/18:2-PI+blood 14:0/18:0-PC+blood 0 0.740196078 0.598632479 serum_phospholipids serum_phospholipids 0.269 0.00289 no no no up up no 16:0/18:2-PI+blood 14:0/18:2-PC+blood 0.523308271 0 0.483076923 serum_phospholipids serum_phospholipids 0.269 0.102 no no no no up no 16:0/18:2-PI+blood 14:0+blood 0.518796992 0 0.424957265 yes serum_phospholipids serum_fattyacid 0.269 0.00572 no no no up no dn 16:0/18:2-PI+blood 14:1/18:2-PG+blood 0.479699248 0 0.574700855 serum_phospholipids serum_phospholipids 0.269 0.00259 no no no no up up 16:0/18:2-PI+blood 16:0-LPC+blood 0 0 0.474871795 serum_phospholipids serum_phospholipids 0.269 0.00456 no no no up up no 16:0/18:2-PI+blood 16:0/16:0-PI+blood 0.830075188 0.681372549 0.794188034 serum_phospholipids serum_phospholipids 0.269 0.358 no no no no no no 16:0/18:2-PI+blood 16:0/16:1-PC+blood 0 0.723039216 0.624615385 serum_phospholipids serum_phospholipids 0.269 0.00283 no no no up up no 16:0/18:2-PI+blood 16:0/16:1-PI+blood 0.726315789 0.634803922 0.825641026 serum_phospholipids serum_phospholipids 0.269 0.262 no no no no no no 16:0/18:2-PI+blood 16:0/18:1-PC+blood -0.684210526 0 0 serum_phospholipids serum_phospholipids 0.269 6.15E-07 no no no up up up 16:0/18:2-PI+blood 16:0/18:1-PE+blood 0.515789474 0.740196078 0 serum_phospholipids serum_phospholipids 0.269 0.000107 no no no up up no 16:0/18:2-PI+blood 16:0+blood 0 0 0.407863248 yes serum_phospholipids serum_fattyacid 0.269 0.00876 no no no up no no 16:0/18:2-PI+blood Acetic acid+stool 0.56043956 0 0 yes serum_phospholipids stool_scfa 0.269 0.0656 no no no dn no no 16:0/18:2-PI+blood Adipocytokine signaling pathway -0.503508772 0 0.554615385 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Alcoholism 0 0 0.423846154 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Aldosterone synthesis and secretion 0 0 0.406923077 serum_phospholipids kegg 0.269 NA no no no no up up 16:0/18:2-PI+blood Alistipes -0.457361747 0 0 serum_phospholipids Genus 0.269 0.0114 no no no no up no 16:0/18:2-PI+blood Amphetamine addiction 0 0 0.412307692 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Axon guidance 0 0.679411765 0 serum_phospholipids kegg 0.269 NA no no no no up up 16:0/18:2-PI+blood B cell receptor signaling pathway -0.464912281 0 0.415384615 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Bacterial invasion of epithelial cells 0 0 -0.436923077 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Biosynthesis of cofactors 0 0 0.450769231 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood C-type lectin receptor signaling pathway 0 0 0.400769231 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Calcium signaling pathway 0 0 0.456923077 serum_phospholipids kegg 0.269 NA no no no no up up 16:0/18:2-PI+blood cAMP signaling pathway 0 0 0.64 yes serum_phospholipids kegg 0.269 NA no no no no up up 16:0/18:2-PI+blood Carbon metabolism 0 0 -0.592307692 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Chagas disease 0 0 0.405384615 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Chemokine signaling pathway -0.471929825 0 0 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Chronic myeloid leukemia 0 0 0.489230769 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Cocaine addiction 0 0 0.694615385 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Cortisol synthesis and secretion 0 0 0.642307692 serum_phospholipids kegg 0.269 NA no no no no no up 16:0/18:2-PI+blood Cushing syndrome 0 0 0.481538462 serum_phospholipids kegg 0.269 NA no no no no no up 16:0/18:2-PI+blood Cytosolic DNA-sensing pathway 0 0 0.546923077 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Endocrine and other factor-regulated calcium reabsorption 0 0 0.404615385 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Fc gamma R-mediated phagocytosis 0 0 -0.466923077 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Ferroptosis 0 0 0.41 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood FoxO signaling pathway 0 -0.555882353 -0.413846154 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood "Glycine, serine and threonine metabolism" 0 0 0.493076923 serum_phospholipids kegg 0.269 NA no no no no up no 16:0/18:2-PI+blood Glycolysis / Gluconeogenesis 0 0 -0.579230769 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood GnRH signaling pathway 0 0 0.406923077 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood "Growth hormone synthesis, secretion and action" 0 0 0.451538462 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Hepatitis B 0 0 0.415384615 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Hepatitis C 0 0 0.544615385 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Influenza A -0.496491228 0 0 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Insulin secretion 0 0 0.559230769 yes serum_phospholipids kegg 0.269 NA no no no no up up 16:0/18:2-PI+blood Kaposi sarcoma-associated herpesvirus infection 0 0 0.549230769 serum_phospholipids kegg 0.269 NA no no no no no dn 16:0/18:2-PI+blood Legionellosis 0.507017544 0 0 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Leukocyte transendothelial migration 0 0.564705882 0 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Long-term depression 0 0 0.533846154 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Longevity regulating pathway - multiple species 0.515789474 0 -0.483846154 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Malaria 0 0 0.442307692 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood MAPK signaling pathway 0 -0.697058824 0 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Measles 0 -0.529411765 0 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Mitophagy - animal 0 0 0.427692308 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Morphine addiction 0 0 0.489230769 serum_phospholipids kegg 0.269 NA no no no no up up 16:0/18:2-PI+blood Neuroactive ligand-receptor interaction 0 0 -0.437692308 serum_phospholipids kegg 0.269 NA no no no up up up 16:0/18:2-PI+blood Neurotrophin signaling pathway 0 0 0.402307692 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood NF-kappa B signaling pathway 0 0 0.427692308 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Non-alcoholic fatty liver disease 0 0 0.401538462 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood p53 signaling pathway 0 -0.502941176 0 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Parabacteroides 0 -0.485294118 0 serum_phospholipids Genus 0.269 4.19E-05 no no no no up up 16:0/18:2-PI+blood Parkinson disease 0 0 0.508461538 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Pathways of neurodegeneration - multiple diseases 0 0 0.503846154 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Phenylacetic acid+stool -0.818681319 0 0 serum_phospholipids stool_cometabolism 0.269 0.785 no no no no no no 16:0/18:2-PI+blood PI3K-Akt signaling pathway 0.524561404 0 0 yes serum_phospholipids kegg 0.269 NA no no no no up up 16:0/18:2-PI+blood Porphyrin and chlorophyll metabolism 0 0 0.466153846 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Primary immunodeficiency 0.680701754 0 -0.545384615 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Progesterone-mediated oocyte maturation 0 0 -0.407692308 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Propionic acid+stool 0.604395604 0 0 yes serum_phospholipids stool_scfa 0.269 0.0436 no no no dn no up 16:0/18:2-PI+blood Prostate cancer 0 0 0.54 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Purine metabolism 0 0 0.412307692 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Relaxin signaling pathway 0 0 0.636153846 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Rheumatoid arthritis 0 0 -0.466923077 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Ribosome biogenesis in eukaryotes 0.464912281 0 0 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood RIG-I-like receptor signaling pathway 0 0 0.556153846 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood RNA transport 0.503508772 0 0 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Roseburia 0 0.539546392 0 butyrate-producing serum_phospholipids Genus 0.269 0.495 no no no no no no 16:0/18:2-PI+blood Ruminococcus 0 0.67443299 0.450546731 serum_phospholipids Genus 0.269 0.0679 no no no no no dn 16:0/18:2-PI+blood Salmonella infection 0 0 -0.421538462 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Small cell lung cancer 0 0 0.612307692 serum_phospholipids kegg 0.269 NA no no no no no up 16:0/18:2-PI+blood Sphingolipid signaling pathway 0 0 -0.528461538 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Spliceosome 0 -0.511764706 0 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood TCA+stool 0 0.663636364 0 serum_phospholipids stool_bileacids 0.269 0.458 no no no no no no 16:0/18:2-PI+blood Th1 and Th2 cell differentiation -0.596491228 0 0 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Th17 cell differentiation -0.468421053 0 0 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Thyroid hormone synthesis 0 0 0.450769231 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Tight junction 0 0.570588235 0 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood TNF signaling pathway 0 0 0.429230769 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood total_stool_scfa+stool 0.598901099 0 0 serum_phospholipids stool_scfa 0.269 0.0534 no no no dn no up 16:0/18:2-PI+blood Transcriptional misregulation in cancer 0 0 0.426923077 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:2-PI+blood Tuberculosis 0 0 -0.506153846 serum_phospholipids kegg 0.269 NA no no no no no dn 16:0/18:2-PI+blood Ubiquitin mediated proteolysis 0 0 0.412307692 serum_phospholipids kegg 0.269 NA no no no no no no 16:0/18:3-PC+blood 12-HEPE+blood -0.50071772 0 0 serum_phospholipids serum_ARA 0.00216 0.312 no up up no no no 16:0/18:3-PC+blood 14:0-LPC+blood 0 0 0.596581197 serum_phospholipids serum_phospholipids 0.00216 0.00689 no up up up up no 16:0/18:3-PC+blood 14:0/16:0-PC+blood 0 0 0.751794872 serum_phospholipids serum_phospholipids 0.00216 0.0358 no up up no up no 16:0/18:3-PC+blood 14:0/18:0-PC+blood 0 0 0.781880342 serum_phospholipids serum_phospholipids 0.00216 0.00289 no up up up up no 16:0/18:3-PC+blood 14:0/18:2-PC+blood 0.542857143 0.602941176 0.567179487 serum_phospholipids serum_phospholipids 0.00216 0.102 no up up no up no 16:0/18:3-PC+blood 14:0/20:4-PC+blood 0.6 0.590686275 0.457094017 serum_phospholipids serum_phospholipids 0.00216 0.486 no up up no no no 16:0/18:3-PC+blood 14:0+blood 0 0 0.513846154 yes serum_phospholipids serum_fattyacid 0.00216 0.00572 no up up up no dn 16:0/18:3-PC+blood 14:1/18:2-PG+blood 0 0 0.466666667 serum_phospholipids serum_phospholipids 0.00216 0.00259 no up up no up up 16:0/18:3-PC+blood 16:0/16:0-PI+blood 0 0 0.515897436 serum_phospholipids serum_phospholipids 0.00216 0.358 no up up no no no 16:0/18:3-PC+blood 16:0/16:1-PC+blood 0 0 0.786666667 serum_phospholipids serum_phospholipids 0.00216 0.00283 no up up up up no 16:0/18:3-PC+blood 16:0/16:1-PI+blood 0 0 0.614358974 serum_phospholipids serum_phospholipids 0.00216 0.262 no up up no no no 16:0/18:3-PC+blood 16:0/18:0-PC+blood 0 0.578431373 0 serum_phospholipids serum_phospholipids 0.00216 0.521 no up up no no no 16:0/18:3-PC+blood 16:0/18:2-PI+blood 0 0 0.557606838 serum_phospholipids serum_phospholipids 0.00216 0.269 no up up no no no 16:0/18:3-PC+blood 16:0+blood 0 0 0.417435897 yes serum_phospholipids serum_fattyacid 0.00216 0.00876 no up up up no no 16:0/18:3-PC+blood Amoebiasis 0 0 -0.42 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Amphetamine addiction -0.549122807 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Antigen processing and presentation 0.624561404 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Biosynthesis of amino acids 0.535087719 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Blautia 0 -0.578431373 0 acetate-producing serum_phospholipids Genus 0.00216 1.36E-05 no up up up dn dn 16:0/18:3-PC+blood CA+stool 0.769230769 0 0 serum_phospholipids stool_bileacids 0.00216 0.827 no up up no no no 16:0/18:3-PC+blood Carbon metabolism 0.559649123 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood CDCA+stool 0.840659341 0 0 serum_phospholipids stool_bileacids 0.00216 0.663 no up up no no no 16:0/18:3-PC+blood Cell adhesion molecules 0.463157895 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Cellular senescence 0.48245614 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Chemical carcinogenesis - receptor activation -0.628070175 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Coprococcus 0 0 -0.426324786 butyrate-producing serum_phospholipids Genus 0.00216 0.612 no up up no no no 16:0/18:3-PC+blood Cushing syndrome -0.571929825 0 0 serum_phospholipids kegg 0.00216 NA no up up no no up 16:0/18:3-PC+blood Dorea 0.466165414 0 0 serum_phospholipids Genus 0.00216 0.00362 no up up up no dn 16:0/18:3-PC+blood Endocrine resistance -0.561403509 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Epstein-Barr virus infection 0.571929825 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Fc gamma R-mediated phagocytosis 0 0 -0.521538462 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood GCA+stool 0 0 0.476691729 serum_phospholipids stool_bileacids 0.00216 0.0809 no up up no no no 16:0/18:3-PC+blood Glucagon signaling pathway -0.463157895 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood "Growth hormone synthesis, secretion and action" -0.457894737 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood HCA+stool 0.785714286 0 0 serum_phospholipids stool_bileacids 0.00216 0.155 no up up no no no 16:0/18:3-PC+blood HDCA+stool -0.67032967 0 0 serum_phospholipids stool_bileacids 0.00216 0.176 no up up no no no 16:0/18:3-PC+blood Herpes simplex virus 1 infection 0.573684211 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Human cytomegalovirus infection 0.542105263 0 0 serum_phospholipids kegg 0.00216 NA no up up no no dn 16:0/18:3-PC+blood Human immunodeficiency virus 1 infection 0.550877193 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Human T-cell leukemia virus 1 infection 0.621052632 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood iso-LCA+stool -0.762036484 0 0 serum_phospholipids stool_bileacids 0.00216 0.72 no up up no no no 16:0/18:3-PC+blood Leishmaniasis 0.563157895 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Long-term depression -0.477192982 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Longevity regulating pathway -0.501754386 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Mineral absorption -0.571929825 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Natural killer cell mediated cytotoxicity 0.50877193 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Necroptosis -0.540350877 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Neuroactive ligand-receptor interaction 0 0 -0.536923077 serum_phospholipids kegg 0.00216 NA no up up up up up 16:0/18:3-PC+blood Non-alcoholic fatty liver disease -0.471929825 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood nutriCA+stool 0.93956044 0 0 serum_phospholipids stool_bileacids 0.00216 0.481 no up up no no no 16:0/18:3-PC+blood "Parathyroid hormone synthesis, secretion and action" -0.557894737 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Parkinson disease -0.464912281 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Pathways of neurodegeneration - multiple diseases -0.459649123 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Pertussis 0.607017544 0 0 serum_phospholipids kegg 0.00216 NA no up up no no dn 16:0/18:3-PC+blood Rheumatoid arthritis 0.463157895 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood Ruminococcus 0.625775533 0 0 serum_phospholipids Genus 0.00216 0.0679 no up up no no dn 16:0/18:3-PC+blood Thermogenesis -0.492982456 0 0 serum_phospholipids kegg 0.00216 NA no up up no no no 16:0/18:3-PC+blood UDCA+stool 0.879120879 0 0 serum_phospholipids stool_bileacids 0.00216 0.266 no up up no no no 16:0/20:3-PC+blood "12,13-EPOME+blood" 0 0 -0.467504408 serum_phospholipids serum_ARA 5.43E-06 0.901 no up up no no no 16:0/20:3-PC+blood 14:0/18:0-PC+blood 0 0.49754902 0 serum_phospholipids serum_phospholipids 5.43E-06 0.00289 no up up up up no 16:0/20:3-PC+blood 16:0-LPC+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 5.43E-06 0.00456 no up up up up no 16:0/20:3-PC+blood 16:0-LPE+blood -0.818045113 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.0711 no up up up up no 16:0/20:3-PC+blood 16:0/14:0-PC+blood 0.517293233 0.705882353 0 serum_phospholipids serum_phospholipids 5.43E-06 0.0206 no up up no up up 16:0/20:3-PC+blood 16:0/16:0-PI+blood -0.616541353 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.358 no up up no no no 16:0/20:3-PC+blood 16:0/16:1-PC+blood 0 0.504901961 0 serum_phospholipids serum_phospholipids 5.43E-06 0.00283 no up up up up no 16:0/20:3-PC+blood 16:0/16:1-PI+blood -0.604511278 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.262 no up up no no no 16:0/20:3-PC+blood 16:0/18:1-PC+blood 0.571428571 0.610294118 0.568547009 serum_phospholipids serum_phospholipids 5.43E-06 6.15E-07 no up up up up up 16:0/20:3-PC+blood 16:0/18:1-PE+blood -0.590977444 0 0 serum_phospholipids serum_phospholipids 5.43E-06 0.000107 no up up up up no 16:0/20:3-PC+blood 16:0/18:2-PC+blood 0.717293233 0.556372549 0.461196581 serum_phospholipids serum_phospholipids 5.43E-06 3.24E-06 no up up no up up 16:0/20:3-PC+blood Adipocytokine signaling pathway 0 0 0.431538462 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Antigen processing and presentation 0 0.614705882 0 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Butyricimonas 0.604099881 0 0 butyrate-producing serum_phospholipids Genus 5.43E-06 0.17 no up up no no no 16:0/20:3-PC+blood CA+stool 0 0.718181818 0 serum_phospholipids stool_bileacids 5.43E-06 0.827 no up up no no no 16:0/20:3-PC+blood Calcium signaling pathway 0.529824561 0 0 serum_phospholipids kegg 5.43E-06 NA no up up no up up 16:0/20:3-PC+blood CDCA+stool 0 0.781818182 0 serum_phospholipids stool_bileacids 5.43E-06 0.663 no up up no no no 16:0/20:3-PC+blood Chemical carcinogenesis - receptor activation 0 -0.5 0 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Colorectal cancer 0 0 -0.423076923 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood DCA+stool 0 0 -0.463157895 serum_phospholipids stool_bileacids 5.43E-06 0.195 no up up no no no 16:0/20:3-PC+blood Epstein-Barr virus infection 0 0.664705882 0 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Ferroptosis 0 0 0.580769231 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Focal adhesion 0 0 -0.424615385 serum_phospholipids kegg 5.43E-06 NA no up up no up up 16:0/20:3-PC+blood FoxO signaling pathway 0 0 -0.458461538 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Fusobacterium 0 -0.513965167 0.462106259 serum_phospholipids Genus 5.43E-06 0.628 no up up no no no 16:0/20:3-PC+blood Gastric cancer 0 0 -0.444615385 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood GCDCA+stool 0 0.8 0 yes serum_phospholipids stool_bileacids 5.43E-06 0.0471 no up up no dn no 16:0/20:3-PC+blood GDCA+stool 0 0.751710379 0 serum_phospholipids stool_bileacids 5.43E-06 0.656 no up up no no no 16:0/20:3-PC+blood HDCA+stool 0 0 -0.523308271 serum_phospholipids stool_bileacids 5.43E-06 0.176 no up up no no no 16:0/20:3-PC+blood Hepatocellular carcinoma 0 0 -0.406153846 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Herpes simplex virus 1 infection 0 0.620588235 0 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Hippo signaling pathway 0 0 -0.428461538 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Human cytomegalovirus infection 0 0.608823529 0 serum_phospholipids kegg 5.43E-06 NA no up up no no dn 16:0/20:3-PC+blood Human immunodeficiency virus 1 infection 0 0.638235294 0 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Human T-cell leukemia virus 1 infection 0 0.611764706 0 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Intestinal immune network for IgA production 0.626315789 0 0 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Kaposi sarcoma-associated herpesvirus infection 0 0 0.507692308 serum_phospholipids kegg 5.43E-06 NA no up up no no dn 16:0/20:3-PC+blood L-Phenylalanine+stool 0 -0.7 0 serum_phospholipids stool_cometabolism 5.43E-06 0.398 no up up no no no 16:0/20:3-PC+blood Lachnospira 0 0 0.472603433 butyrate-producing serum_phospholipids Genus 5.43E-06 0.279 no up up no no no 16:0/20:3-PC+blood Malaria 0 0 0.492307692 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Mineral absorption 0 0 0.511538462 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Mitophagy - animal 0 0 0.440769231 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Necroptosis 0 0 0.496923077 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood nutriCA+stool 0 0.651403561 0 serum_phospholipids stool_bileacids 5.43E-06 0.481 no up up no no no 16:0/20:3-PC+blood Oocyte meiosis 0 0 -0.404615385 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Phenylacetic acid+stool 0 -0.845454545 0 serum_phospholipids stool_cometabolism 5.43E-06 0.785 no up up no no no 16:0/20:3-PC+blood Phosphatidylinositol signaling system 0 0 -0.474615385 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Porphyrin and chlorophyll metabolism 0 0 0.403076923 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Prevotella -0.544827422 0 0 acetate-producing serum_phospholipids Genus 5.43E-06 0.287 no up up no no no 16:0/20:3-PC+blood Progesterone-mediated oocyte maturation 0 0 -0.401538462 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Purine metabolism 0 0 0.436153846 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Shigellosis 0 0 0.42 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Signaling pathways regulating pluripotency of stem cells 0 0 -0.407692308 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Sphingolipid signaling pathway 0 0 -0.435384615 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood TCA+stool 0 0 0.505263158 serum_phospholipids stool_bileacids 5.43E-06 0.458 no up up no no no 16:0/20:3-PC+blood Th1 and Th2 cell differentiation 0.459649123 0 0 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Th17 cell differentiation 0.456140351 0 0 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Thyroid hormone signaling pathway 0 0 -0.49 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood Ubiquitin mediated proteolysis 0 0 0.43 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:3-PC+blood UDCA+stool 0 0.663636364 0 serum_phospholipids stool_bileacids 5.43E-06 0.266 no up up no no no 16:0/20:3-PC+blood Viral protein interaction with cytokine and cytokine receptor 0.459649123 0 0 serum_phospholipids kegg 5.43E-06 NA no up up no no no 16:0/20:4-PC+blood 14:0/18:0-PC+blood 0 -0.524509804 0 serum_phospholipids serum_phospholipids 0.0262 0.00289 no up no up up no 16:0/20:4-PC+blood 16:0-LPC+blood 0 0 -0.515897436 serum_phospholipids serum_phospholipids 0.0262 0.00456 no up no up up no 16:0/20:4-PC+blood 16:0-LPE+blood -0.551879699 0 0 serum_phospholipids serum_phospholipids 0.0262 0.0711 no up no up up no 16:0/20:4-PC+blood 16:0/14:0-PC+blood 0.65112782 0 0.59042735 serum_phospholipids serum_phospholipids 0.0262 0.0206 no up no no up up 16:0/20:4-PC+blood 16:0/16:0-PC+blood 0 0 0.433162393 serum_phospholipids serum_phospholipids 0.0262 0.00079 no up no no up up 16:0/20:4-PC+blood 16:0/16:0-PI+blood -0.596992481 -0.666666667 0 serum_phospholipids serum_phospholipids 0.0262 0.358 no up no no no no 16:0/20:4-PC+blood 16:0/16:1-PC+blood 0 -0.529411765 0 serum_phospholipids serum_phospholipids 0.0262 0.00283 no up no up up no 16:0/20:4-PC+blood 16:0/16:1-PI+blood -0.64962406 -0.62254902 0 serum_phospholipids serum_phospholipids 0.0262 0.262 no up no no no no 16:0/20:4-PC+blood 16:0/18:1-PC+blood 0.741353383 0.556372549 0 serum_phospholipids serum_phospholipids 0.0262 6.15E-07 no up no up up up 16:0/20:4-PC+blood 16:0/18:1-PE+blood -0.606015038 -0.56127451 0 serum_phospholipids serum_phospholipids 0.0262 0.000107 no up no up up no 16:0/20:4-PC+blood 16:0/18:2-PC+blood 0.654135338 0.49754902 0.554188034 serum_phospholipids serum_phospholipids 0.0262 3.24E-06 no up no no up up 16:0/20:4-PC+blood 16:0/18:2-PI+blood -0.590977444 -0.767156863 0 serum_phospholipids serum_phospholipids 0.0262 0.269 no up no no no no 16:0/20:4-PC+blood 16:0/20:3-PC+blood 0.551879699 0 0.448205128 serum_phospholipids serum_phospholipids 0.0262 5.43E-06 no up no no up up 16:0/20:4-PC+blood Alistipes 0.462644803 0 0 serum_phospholipids Genus 0.0262 0.0114 no up no no up no 16:0/20:4-PC+blood Amyotrophic lateral sclerosis 0 0 -0.400769231 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PC+blood Asthma 0 0 -0.504615385 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PC+blood Autophagy - animal 0 0 0.451538462 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PC+blood Axon guidance 0 -0.576470588 0 serum_phospholipids kegg 0.0262 NA no up no no up up 16:0/20:4-PC+blood Cardiac muscle contraction 0 0 -0.405384615 serum_phospholipids kegg 0.0262 NA no up no no no up 16:0/20:4-PC+blood Diabetic cardiomyopathy 0 0 -0.448461538 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PC+blood Dilated cardiomyopathy 0 0 -0.428461538 serum_phospholipids kegg 0.0262 NA no up no no up up 16:0/20:4-PC+blood Gastric acid secretion 0 0 -0.450769231 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PC+blood HDCA+stool 0.598901099 0 0 serum_phospholipids stool_bileacids 0.0262 0.176 no up no no no no 16:0/20:4-PC+blood Hematopoietic cell lineage 0 0 -0.503076923 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PC+blood Hepatocellular carcinoma 0 0 -0.438461538 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PC+blood Inflammatory bowel disease 0 0 -0.534615385 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PC+blood Lachnospira 0 0 0.531850095 butyrate-producing serum_phospholipids Genus 0.0262 0.279 no up no no no no 16:0/20:4-PC+blood MAPK signaling pathway 0 0 0.409230769 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PC+blood Prion disease 0 0 -0.436153846 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PC+blood Renal cell carcinoma 0 -0.526470588 0 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PC+blood Th1 and Th2 cell differentiation 0.512280702 0 0 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PC+blood Th17 cell differentiation 0.461403509 0 0 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PC+blood Thermogenesis 0 0 -0.413076923 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PC+blood Thyroid hormone signaling pathway 0 0 -0.523076923 serum_phospholipids kegg 0.0262 NA no up no no no no 16:0/20:4-PE+blood 11-HETE+blood 0 0.501879937 0 serum_phospholipids serum_ARA 0.00139 0.464 up up no no no no 16:0/20:4-PE+blood 12-ketoDCA+blood 0 -0.576306805 0 serum_phospholipids serum_bileacids 0.00139 0.517 up up no no no no 16:0/20:4-PE+blood 15-HETE+blood -0.496983959 0 0 serum_phospholipids serum_ARA 0.00139 0.819 up up no no no no 16:0/20:4-PE+blood 16:0-LPE+blood 0.657142857 0.595588235 0.448205128 serum_phospholipids serum_phospholipids 0.00139 0.0711 up up no up up no 16:0/20:4-PE+blood 16:0/16:0-PI+blood 0.479699248 0 0 serum_phospholipids serum_phospholipids 0.00139 0.358 up up no no no no 16:0/20:4-PE+blood 16:0/18:0-PC+blood 0 0 -0.498803419 serum_phospholipids serum_phospholipids 0.00139 0.521 up up no no no no 16:0/20:4-PE+blood 16:0/18:0-PS+blood 0.705263158 0.495098039 0.515897436 serum_phospholipids serum_phospholipids 0.00139 0.377 up up no no no no 16:0/20:4-PE+blood 16:0/18:1-PE+blood 0.809022556 0.828431373 0.868717949 serum_phospholipids serum_phospholipids 0.00139 0.000107 up up no up up no 16:0/20:4-PE+blood 16:0/20:3-PC+blood -0.589473684 0 0 serum_phospholipids serum_phospholipids 0.00139 5.43E-06 up up no no up up 16:0/20:4-PI+blood 11-HETE+blood -0.487119845 0 0 serum_phospholipids serum_ARA 0.558 0.464 no no no no no no 16:0/20:4-PI+blood 13-HODE+blood 0 -0.593137255 0 serum_phospholipids serum_ARA 0.558 0.32 no no no no no no 16:0/20:4-PI+blood 14:0-LPC+blood 0.57593985 0 0.557606838 serum_phospholipids serum_phospholipids 0.558 0.00689 no no no up up no 16:0/20:4-PI+blood 14:0/16:0-PC+blood 0 0 0.538461538 serum_phospholipids serum_phospholipids 0.558 0.0358 no no no no up no 16:0/20:4-PI+blood 14:0/18:0-PC+blood 0 0 0.51042735 serum_phospholipids serum_phospholipids 0.558 0.00289 no no no up up no 16:0/20:4-PI+blood 14:0/20:4-PC+blood 0.487218045 0 0 serum_phospholipids serum_phospholipids 0.558 0.486 no no no no no no 16:0/20:4-PI+blood 14:0+blood 0.448120301 0 0 yes serum_phospholipids serum_fattyacid 0.558 0.00572 no no no up no dn 16:0/20:4-PI+blood 14:1/18:2-PG+blood 0 0 0.483076923 serum_phospholipids serum_phospholipids 0.558 0.00259 no no no no up up 16:0/20:4-PI+blood 16:0/16:0-PI+blood 0.741353383 0 0.672478632 serum_phospholipids serum_phospholipids 0.558 0.358 no no no no no no 16:0/20:4-PI+blood 16:0/16:1-PC+blood 0 0 0.548717949 serum_phospholipids serum_phospholipids 0.558 0.00283 no no no up up no 16:0/20:4-PI+blood 16:0/16:1-PI+blood 0.781954887 0.615196078 0.811282051 serum_phospholipids serum_phospholipids 0.558 0.262 no no no no no no 16:0/20:4-PI+blood 16:0/18:1-PC+blood -0.669172932 0 0 serum_phospholipids serum_phospholipids 0.558 6.15E-07 no no no up up up 16:0/20:4-PI+blood 16:0/18:1-PE+blood 0 0 0.458461538 serum_phospholipids serum_phospholipids 0.558 0.000107 no no no up up no 16:0/20:4-PI+blood 16:0/18:2-PC+blood -0.536842105 -0.580882353 0 serum_phospholipids serum_phospholipids 0.558 3.24E-06 no no no no up up 16:0/20:4-PI+blood 16:0/18:2-PI+blood 0.810526316 0.602941176 0.848205128 serum_phospholipids serum_phospholipids 0.558 0.269 no no no no no no 16:0/20:4-PI+blood 16:0/18:3-PC+blood 0 0 0.476239316 serum_phospholipids serum_phospholipids 0.558 0.00216 no no no no up up 16:0/20:4-PI+blood 16:0/20:3-PC+blood -0.547368421 0 0 serum_phospholipids serum_phospholipids 0.558 5.43E-06 no no no no up up 16:0/20:4-PI+blood 16:0/20:4-PC+blood 0 -0.661764706 0 serum_phospholipids serum_phospholipids 0.558 0.0262 no no no no up no 16:0/20:4-PI+blood 16:0+blood 0 0 0.476923077 yes serum_phospholipids serum_fattyacid 0.558 0.00876 no no no up no no 16:0/20:4-PI+blood Adipocytokine signaling pathway 0 0 0.419230769 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Alcoholism 0 0 0.417692308 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Aldosterone synthesis and secretion 0 0 0.425384615 serum_phospholipids kegg 0.558 NA no no no no up up 16:0/20:4-PI+blood Amphetamine addiction 0 0 0.42 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Apoptosis -0.466666667 0 0 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Asthma -0.556140351 0 0 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood C-type lectin receptor signaling pathway 0 0 0.437692308 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Calcium signaling pathway 0 0 0.557692308 serum_phospholipids kegg 0.558 NA no no no no up up 16:0/20:4-PI+blood cAMP signaling pathway 0 0 0.635384615 yes serum_phospholipids kegg 0.558 NA no no no no up up 16:0/20:4-PI+blood Carbon metabolism 0 0 -0.503076923 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Central carbon metabolism in cancer 0.477192982 0 0 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Chagas disease 0 0 0.408461538 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Cocaine addiction 0 0 0.687692308 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Coprococcus 0.607518797 0 0 butyrate-producing serum_phospholipids Genus 0.558 0.612 no no no no no no 16:0/20:4-PI+blood Cortisol synthesis and secretion 0 0 0.593076923 serum_phospholipids kegg 0.558 NA no no no no no up 16:0/20:4-PI+blood Cushing syndrome 0 0 0.496923077 serum_phospholipids kegg 0.558 NA no no no no no up 16:0/20:4-PI+blood Cytosolic DNA-sensing pathway 0 0 0.517692308 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood FoxO signaling pathway 0 0 -0.416153846 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Glycolysis / Gluconeogenesis 0 0 -0.506923077 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood GnRH signaling pathway 0 0 0.461538462 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood "Growth hormone synthesis, secretion and action" 0 0 0.463076923 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood HDCA+stool 0 -0.772727273 0 serum_phospholipids stool_bileacids 0.558 0.176 no no no no no no 16:0/20:4-PI+blood Hepatitis B 0 0 0.432307692 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Hepatitis C 0 0 0.510769231 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Inflammatory bowel disease -0.492982456 0 0 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Influenza A -0.671929825 0 0 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Insulin secretion 0 0 0.549230769 yes serum_phospholipids kegg 0.558 NA no no no no up up 16:0/20:4-PI+blood Insulin signaling pathway 0.457894737 0 0 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Intestinal immune network for IgA production -0.5 0 0 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Kaposi sarcoma-associated herpesvirus infection 0 0 0.435384615 serum_phospholipids kegg 0.558 NA no no no no no dn 16:0/20:4-PI+blood Legionellosis 0.475438596 0 0 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Long-term depression 0 0 0.513846154 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Longevity regulating pathway - multiple species 0.578947368 0 -0.528461538 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Melanogenesis 0 0 0.438461538 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Morphine addiction 0 0 0.446153846 serum_phospholipids kegg 0.558 NA no no no no up up 16:0/20:4-PI+blood Neurotrophin signaling pathway 0 0 0.486153846 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Odoribacter 0 0.541998876 0 butyrate-producing serum_phospholipids Genus 0.558 0.798 no no no no no no 16:0/20:4-PI+blood "Parathyroid hormone synthesis, secretion and action" 0 0 0.45 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Pathways in cancer 0 -0.552941176 0 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Phenylacetic acid+stool -0.741758242 0 0 serum_phospholipids stool_cometabolism 0.558 0.785 no no no no no no 16:0/20:4-PI+blood PI3K-Akt signaling pathway 0.563157895 0 0 yes serum_phospholipids kegg 0.558 NA no no no no up up 16:0/20:4-PI+blood Primary immunodeficiency 0.587719298 0 -0.576923077 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Prostate cancer 0 0 0.520769231 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Relaxin signaling pathway 0 0 0.64 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Rheumatoid arthritis -0.489473684 0 0 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood RIG-I-like receptor signaling pathway 0 0 0.504615385 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood RNA transport 0.556140351 0 0 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Ruminococcus 0 0 0.498452965 serum_phospholipids Genus 0.558 0.0679 no no no no no dn 16:0/20:4-PI+blood Small cell lung cancer 0 0 0.483846154 serum_phospholipids kegg 0.558 NA no no no no no up 16:0/20:4-PI+blood TCA+stool 0.591472361 0 0 serum_phospholipids stool_bileacids 0.558 0.458 no no no no no no 16:0/20:4-PI+blood Th1 and Th2 cell differentiation -0.624561404 0 0 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Th17 cell differentiation -0.554385965 0 0 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood TNF signaling pathway 0 0 0.414615385 serum_phospholipids kegg 0.558 NA no no no no no no 16:0/20:4-PI+blood Tuberculosis 0 0 -0.403076923 serum_phospholipids kegg 0.558 NA no no no no no dn 16:0/20:5-PC+blood 12-HEPE+blood 0 0.493977261 0 serum_phospholipids serum_ARA 0.628 0.312 no no no no no no 16:0/20:5-PC+blood 14:0/20:4-PC+blood 0.57593985 0 0 serum_phospholipids serum_phospholipids 0.628 0.486 no no no no no no 16:0/20:5-PC+blood 16:0/18:0-PC+blood 0 0.583333333 0 serum_phospholipids serum_phospholipids 0.628 0.521 no no no no no no 16:0/20:5-PC+blood 16:0/18:0-PS+blood 0 0.504901961 0 serum_phospholipids serum_phospholipids 0.628 0.377 no no no no no no 16:0/20:5-PC+blood 16:0/18:1-PE+blood 0 -0.5 0 serum_phospholipids serum_phospholipids 0.628 0.000107 no no no up up no 16:0/20:5-PC+blood 16:0/18:3-PC+blood 0 0.541666667 0 serum_phospholipids serum_phospholipids 0.628 0.00216 no no no no up up 16:0/20:5-PC+blood 16:0/20:3-PC+blood 0 0 -0.533675214 serum_phospholipids serum_phospholipids 0.628 5.43E-06 no no no no up up 16:0/20:5-PC+blood Adlercreutzia 0 0 -0.40383105 serum_phospholipids Genus 0.628 0.548 no no no no no no 16:0/20:5-PC+blood Amoebiasis 0 -0.523529412 0 serum_phospholipids kegg 0.628 NA no no no no no no 16:0/20:5-PC+blood Bacteroides 0 0.578431373 0 LPS-producing serum_phospholipids Genus 0.628 0.000267 no no no dn dn up 16:0/20:5-PC+blood Blautia 0.446616541 0 0 acetate-producing serum_phospholipids Genus 0.628 1.36E-05 no no no up dn dn 16:0/20:5-PC+blood Butyric acid+stool 0 -0.672727273 0 yes serum_phospholipids stool_scfa 0.628 0.102 no no no dn no no 16:0/20:5-PC+blood cAMP signaling pathway 0 -0.579411765 0 yes serum_phospholipids kegg 0.628 NA no no no no up up 16:0/20:5-PC+blood Cholinergic synapse 0 0.514705882 0 serum_phospholipids kegg 0.628 NA no no no no no no 16:0/20:5-PC+blood Clostridium 0 -0.491722962 0 serum_phospholipids Genus 0.628 0.925 no no no no no no 16:0/20:5-PC+blood Coprococcus 0.613533835 0 0 butyrate-producing serum_phospholipids Genus 0.628 0.612 no no no no no no 16:0/20:5-PC+blood Ferroptosis 0 -0.573529412 0 serum_phospholipids kegg 0.628 NA no no no no no no 16:0/20:5-PC+blood Hematopoietic cell lineage 0 0.564705882 0 serum_phospholipids kegg 0.628 NA no no no no no no 16:0/20:5-PC+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.711764706 0 serum_phospholipids kegg 0.628 NA no no no no no dn 16:0/20:5-PC+blood Malaria 0 -0.576470588 0 serum_phospholipids kegg 0.628 NA no no no no no no 16:0/20:5-PC+blood MAPK signaling pathway 0 0.597058824 0 serum_phospholipids kegg 0.628 NA no no no no no no 16:0/20:5-PC+blood Parabacteroides 0 0.551470588 0 serum_phospholipids Genus 0.628 4.19E-05 no no no no up up 16:0/20:5-PC+blood Primary immunodeficiency 0 0.514705882 0 serum_phospholipids kegg 0.628 NA no no no no no no 16:0/20:5-PC+blood Progesterone-mediated oocyte maturation 0 0.511764706 0 serum_phospholipids kegg 0.628 NA no no no no no no 16:0/20:5-PC+blood Propionic acid+stool 0 0 0.545864662 yes serum_phospholipids stool_scfa 0.628 0.0436 no no no dn no up 16:0/20:5-PC+blood Renal cell carcinoma -0.5 0 0 serum_phospholipids kegg 0.628 NA no no no no no no 16:0/20:5-PC+blood Shigellosis 0 -0.573529412 0 serum_phospholipids kegg 0.628 NA no no no no no no 16:0/20:5-PC+blood TCA+stool 0 0 -0.526315789 serum_phospholipids stool_bileacids 0.628 0.458 no no no no no no 16:0/20:5-PC+blood Viral protein interaction with cytokine and cytokine receptor 0 -0.541176471 0 serum_phospholipids kegg 0.628 NA no no no no no no 16:0/20:5-PG+blood "12,13-EPOME+blood" 0 -0.655135439 0 serum_phospholipids serum_ARA 0.00656 0.901 no up no no no no 16:0/20:5-PG+blood 13-HODE+blood 0 0 -0.528888889 serum_phospholipids serum_ARA 0.00656 0.32 no up no no no no 16:0/20:5-PG+blood 14:0-LPC+blood -0.676691729 0 0 serum_phospholipids serum_phospholipids 0.00656 0.00689 no up no up up no 16:0/20:5-PG+blood 14:0/18:2-PC+blood -0.467669173 0 0 serum_phospholipids serum_phospholipids 0.00656 0.102 no up no no up no 16:0/20:5-PG+blood 14:0+blood -0.461654135 0 0 yes serum_phospholipids serum_fattyacid 0.00656 0.00572 no up no up no dn 16:0/20:5-PG+blood 14:1/18:2-PG+blood -0.515789474 0 0 serum_phospholipids serum_phospholipids 0.00656 0.00259 no up no no up up 16:0/20:5-PG+blood 16:0/14:0-PC+blood 0 -0.531862745 0 serum_phospholipids serum_phospholipids 0.00656 0.0206 no up no no up up 16:0/20:5-PG+blood 16:0/16:1-PI+blood -0.479699248 0 0 serum_phospholipids serum_phospholipids 0.00656 0.262 no up no no no no 16:0/20:5-PG+blood 16:0/18:0-PS+blood 0 0 0.461880342 serum_phospholipids serum_phospholipids 0.00656 0.377 no up no no no no 16:0/20:5-PG+blood 16:0/18:2-PI+blood -0.569924812 0 0 serum_phospholipids serum_phospholipids 0.00656 0.269 no up no no no no 16:0/20:5-PG+blood 16:0/20:4-PC+blood 0.527819549 0 0 serum_phospholipids serum_phospholipids 0.00656 0.0262 no up no no up no 16:0/22:0-PE+blood 16:0-LPE+blood 0 -0.551470588 0 serum_phospholipids serum_phospholipids 0.00839 0.0711 dn no up up up no 16:0/22:0-PE+blood 16:0/16:1-PI+blood 0 0 -0.517948718 serum_phospholipids serum_phospholipids 0.00839 0.262 dn no up no no no 16:0/22:0-PE+blood 16:0/18:0-PC+blood 0 0 0.616410256 serum_phospholipids serum_phospholipids 0.00839 0.521 dn no up no no no 16:0/22:0-PE+blood 16:0/18:2-PI+blood 0 0 -0.414017094 serum_phospholipids serum_phospholipids 0.00839 0.269 dn no up no no no 16:0/22:0-PE+blood 16:0/20:4-PI+blood 0 0 -0.439316239 serum_phospholipids serum_phospholipids 0.00839 0.558 dn no up no no no 16:0/22:0-PE+blood 16:0/20:5-PC+blood 0 0.634803922 0 serum_phospholipids serum_phospholipids 0.00839 0.628 dn no up no no no 16:0/22:6-PC+blood 14:0-LPC+blood 0 -0.509803922 0 serum_phospholipids serum_phospholipids 4.53E-05 0.00689 no up up up up no 16:0/22:6-PC+blood 14:0/18:0-PC+blood 0 -0.595588235 0 serum_phospholipids serum_phospholipids 4.53E-05 0.00289 no up up up up no 16:0/22:6-PC+blood 14:0/20:4-PC+blood 0 0 -0.481025641 serum_phospholipids serum_phospholipids 4.53E-05 0.486 no up up no no no 16:0/22:6-PC+blood 14:1/18:2-PG+blood 0 0 -0.437948718 serum_phospholipids serum_phospholipids 4.53E-05 0.00259 no up up no up up 16:0/22:6-PC+blood 16:0/14:0-PC+blood 0 0 0.513162393 serum_phospholipids serum_phospholipids 4.53E-05 0.0206 no up up no up up 16:0/22:6-PC+blood 16:0/16:0-PC+blood 0.622556391 0 0.487863248 serum_phospholipids serum_phospholipids 4.53E-05 0.00079 no up up no up up 16:0/22:6-PC+blood 16:0/16:0-PI+blood 0 -0.68872549 0 serum_phospholipids serum_phospholipids 4.53E-05 0.358 no up up no no no 16:0/22:6-PC+blood 16:0/16:1-PC+blood 0 -0.568627451 0 serum_phospholipids serum_phospholipids 4.53E-05 0.00283 no up up up up no 16:0/22:6-PC+blood 16:0/16:1-PI+blood -0.479699248 -0.620098039 0 serum_phospholipids serum_phospholipids 4.53E-05 0.262 no up up no no no 16:0/22:6-PC+blood 16:0/18:0-PC+blood 0.496240602 0 0.424273504 serum_phospholipids serum_phospholipids 4.53E-05 0.521 no up up no no no 16:0/22:6-PC+blood 16:0/18:1-PC+blood 0.479699248 0.585784314 0.478974359 serum_phospholipids serum_phospholipids 4.53E-05 6.15E-07 no up up up up up 16:0/22:6-PC+blood 16:0/18:1-PE+blood 0 -0.539215686 0 serum_phospholipids serum_phospholipids 4.53E-05 0.000107 no up up up up no 16:0/22:6-PC+blood 16:0/18:2-PC+blood 0.604511278 0 0.74974359 serum_phospholipids serum_phospholipids 4.53E-05 3.24E-06 no up up no up up 16:0/22:6-PC+blood 16:0/18:2-PI+blood 0 -0.632352941 0 serum_phospholipids serum_phospholipids 4.53E-05 0.269 no up up no no no 16:0/22:6-PC+blood 16:0/20:4-PC+blood 0 0.764705882 0 serum_phospholipids serum_phospholipids 4.53E-05 0.0262 no up up no up no 16:0/22:6-PC+blood 16:0/20:5-PC+blood 0 0.588235294 0 serum_phospholipids serum_phospholipids 4.53E-05 0.628 no up up no no no 16:0/22:6-PC+blood 16:0/22:0-PE+blood 0.777443609 0.632352941 0.643076923 serum_phospholipids serum_phospholipids 4.53E-05 0.00839 no up up dn no up 16:0/22:6-PC+blood AGE-RAGE signaling pathway in diabetic complications 0.521052632 0 0 serum_phospholipids kegg 4.53E-05 NA no up up no no no 16:0/22:6-PC+blood Alzheimer disease 0 0 -0.438461538 serum_phospholipids kegg 4.53E-05 NA no up up no no no 16:0/22:6-PC+blood Amyotrophic lateral sclerosis 0 0 -0.436923077 serum_phospholipids kegg 4.53E-05 NA no up up no no no 16:0/22:6-PC+blood Bacteroides 0 0.536764706 0 LPS-producing serum_phospholipids Genus 4.53E-05 0.000267 no up up dn dn up 16:0/22:6-PC+blood Blautia 0 0 -0.418184279 acetate-producing serum_phospholipids Genus 4.53E-05 1.36E-05 no up up up dn dn 16:0/22:6-PC+blood CA+stool 0 0 -0.445112782 serum_phospholipids stool_bileacids 4.53E-05 0.827 no up up no no no 16:0/22:6-PC+blood Carbon metabolism 0 0 0.404615385 serum_phospholipids kegg 4.53E-05 NA no up up no no no 16:0/22:6-PC+blood Cardiac muscle contraction 0 0 -0.455384615 serum_phospholipids kegg 4.53E-05 NA no up up no no up 16:0/22:6-PC+blood CDCA+stool 0 0 -0.482706767 serum_phospholipids stool_bileacids 4.53E-05 0.663 no up up no no no 16:0/22:6-PC+blood IL-17 signaling pathway 0 0 0.41 serum_phospholipids kegg 4.53E-05 NA no up up no no no 16:0/22:6-PC+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.647058824 0 serum_phospholipids kegg 4.53E-05 NA no up up no no dn 16:0/22:6-PC+blood L-Phenylalanine+stool 0 0 0.639097744 serum_phospholipids stool_cometabolism 4.53E-05 0.398 no up up no no no 16:0/22:6-PC+blood L-Tryptophan+stool 0 0 0.562406015 serum_phospholipids stool_cometabolism 4.53E-05 0.557 no up up no no no 16:0/22:6-PC+blood L-Tyrosine+stool 0 0 0.634586466 serum_phospholipids stool_cometabolism 4.53E-05 0.44 no up up no no no 16:0/22:6-PC+blood Lysosome 0 0 0.426153846 serum_phospholipids kegg 4.53E-05 NA no up up no no no 16:0/22:6-PC+blood MAPK signaling pathway 0 0.544117647 0 serum_phospholipids kegg 4.53E-05 NA no up up no no no 16:0/22:6-PC+blood Parabacteroides 0 0.531862745 0 serum_phospholipids Genus 4.53E-05 4.19E-05 no up up no up up 16:0/22:6-PC+blood Peroxisome 0 0 0.467692308 serum_phospholipids kegg 4.53E-05 NA no up up no no no 16:0/22:6-PC+blood Pertussis 0.471929825 0 0 serum_phospholipids kegg 4.53E-05 NA no up up no no dn 16:0/22:6-PC+blood Renal cell carcinoma 0 -0.5 0 serum_phospholipids kegg 4.53E-05 NA no up up no no no 16:0/22:6-PC+blood Retrograde endocannabinoid signaling 0 0 -0.406923077 serum_phospholipids kegg 4.53E-05 NA no up up no no up 16:0/22:6-PC+blood Shigellosis 0 -0.529411765 0 serum_phospholipids kegg 4.53E-05 NA no up up no no no 16:0/22:6-PC+blood TCA+stool 0 -0.627272727 0 serum_phospholipids stool_bileacids 4.53E-05 0.458 no up up no no no 16:0/22:6-PC+blood UDCA+stool 0 0 -0.466165414 serum_phospholipids stool_bileacids 4.53E-05 0.266 no up up no no no 16:0/22:6-PE+blood 12-ketoDCA+blood 0 -0.513736352 0 serum_phospholipids serum_bileacids 0.000934 0.517 up up no no no no 16:0/22:6-PE+blood 12-ketoDCA+stool 0 0 0.578947368 serum_phospholipids stool_bileacids 0.000934 0.505 up up no no no no 16:0/22:6-PE+blood 16:0-LPE+blood 0.57443609 0 0.462564103 serum_phospholipids serum_phospholipids 0.000934 0.0711 up up no up up no 16:0/22:6-PE+blood 16:0/18:0-PS+blood 0.870676692 0.75 0.610940171 serum_phospholipids serum_phospholipids 0.000934 0.377 up up no no no no 16:0/22:6-PE+blood 16:0/18:1-PE+blood 0.717293233 0.492647059 0.890598291 serum_phospholipids serum_phospholipids 0.000934 0.000107 up up no up up no 16:0/22:6-PE+blood 16:0/20:3-PC+blood -0.473684211 0 0 serum_phospholipids serum_phospholipids 0.000934 5.43E-06 up up no no up up 16:0/22:6-PE+blood 16:0/20:4-PE+blood 0.765413534 0.767156863 0.909059829 serum_phospholipids serum_phospholipids 0.000934 0.00139 up up no up up no 16:0/22:6-PE+blood Adrenergic signaling in cardiomyocytes -0.477192982 0 0 serum_phospholipids kegg 0.000934 NA up up no no no up 16:0/22:6-PE+blood Allograft rejection 0 0 0.403846154 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Amoebiasis 0 0 0.429230769 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Antigen processing and presentation 0 0 0.499230769 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Autoimmune thyroid disease 0 0 0.403846154 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Axon guidance 0 0 0.421538462 serum_phospholipids kegg 0.000934 NA up up no no up up 16:0/22:6-PE+blood Calcium signaling pathway -0.466666667 0 0 serum_phospholipids kegg 0.000934 NA up up no no up up 16:0/22:6-PE+blood Cell adhesion molecules 0 0 0.498461538 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Cellular senescence 0 0 0.465384615 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood cGMP-PKG signaling pathway 0 0 0.564615385 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Chagas disease 0 0 0.508461538 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Cholinergic synapse 0 0.538235294 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Coronavirus disease - COVID-19 -0.547368421 0 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Endocytosis 0 0 0.458461538 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Epithelial cell signaling in Helicobacter pylori infection 0 0 0.560769231 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Epstein-Barr virus infection 0 0 0.522307692 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Fc gamma R-mediated phagocytosis 0.557894737 0 0.421538462 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Ferroptosis -0.471929825 0 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood GABAergic synapse 0 0 0.445384615 serum_phospholipids kegg 0.000934 NA up up no no up up 16:0/22:6-PE+blood GCA+stool 0.620879121 0 0 serum_phospholipids stool_bileacids 0.000934 0.0809 up up no no no no 16:0/22:6-PE+blood Graft-versus-host disease 0 0 0.437692308 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Herpes simplex virus 1 infection 0 0 0.421538462 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Human cytomegalovirus infection 0 0 0.638461538 serum_phospholipids kegg 0.000934 NA up up no no no dn 16:0/22:6-PE+blood Human immunodeficiency virus 1 infection 0 0 0.573846154 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Human papillomavirus infection 0 0 0.533076923 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Human T-cell leukemia virus 1 infection 0 0 0.511538462 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood IL-17 signaling pathway 0 0 0.484615385 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Intestinal immune network for IgA production -0.731578947 0 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Kaposi sarcoma-associated herpesvirus infection -0.587719298 0 0 serum_phospholipids kegg 0.000934 NA up up no no no dn 16:0/22:6-PE+blood L-Phenylalanine+stool 0.708791209 0 0 serum_phospholipids stool_cometabolism 0.000934 0.398 up up no no no no 16:0/22:6-PE+blood L-Tryptophan+stool 0.71978022 0 0 serum_phospholipids stool_cometabolism 0.000934 0.557 up up no no no no 16:0/22:6-PE+blood L-Tyrosine+stool 0.587912088 0 -0.457142857 serum_phospholipids stool_cometabolism 0.000934 0.44 up up no no no no 16:0/22:6-PE+blood Lachnospira 0.476691729 0 0 butyrate-producing serum_phospholipids Genus 0.000934 0.279 up up no no no no 16:0/22:6-PE+blood Lipid and atherosclerosis 0 0 0.568461538 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Longevity regulating pathway - multiple species 0.477192982 0 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood MAPK signaling pathway 0.484210526 0 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Mineral absorption -0.485964912 0 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Mitophagy - animal -0.487719298 0 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Natural killer cell mediated cytotoxicity 0 0 0.503076923 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Necroptosis -0.512280702 0 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Neuroactive ligand-receptor interaction 0 0 0.408461538 serum_phospholipids kegg 0.000934 NA up up no up up up 16:0/22:6-PE+blood Neutrophil extracellular trap formation 0 0 0.415384615 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Olfactory transduction 0.578947368 0 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Osteoclast differentiation 0.531578947 0 0.509230769 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Pertussis 0 0 0.552307692 serum_phospholipids kegg 0.000934 NA up up no no no dn 16:0/22:6-PE+blood Phagosome 0 0 0.44 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Platinum drug resistance 0 0 -0.464615385 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood PPAR signaling pathway 0 0 0.698461538 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Ribosome -0.547368421 0 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Ribosome biogenesis in eukaryotes 0 0 -0.429230769 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Salmonella infection 0.475438596 0 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Serotonergic synapse 0 0 0.46 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Shigellosis -0.464912281 0 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Slackia 0 0 -0.404920521 serum_phospholipids Genus 0.000934 0.94 up up no no no no 16:0/22:6-PE+blood Th1 and Th2 cell differentiation 0 -0.502941176 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Th17 cell differentiation 0 -0.558823529 0 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Toll-like receptor signaling pathway 0 0 0.515384615 yes serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Type I diabetes mellitus 0 0 0.406923077 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0/22:6-PE+blood Viral carcinogenesis 0 0 0.541538462 serum_phospholipids kegg 0.000934 NA up up no no no no 16:0+blood 12-HEPE+blood -0.510393425 0 0 yes serum_fattyacid serum_ARA 0.00876 0.312 up no no no no no 16:0+blood 14:0-LPC+blood 0 0 0.476239316 yes serum_fattyacid serum_phospholipids 0.00876 0.00689 up no no up up no 16:0+blood 14:0/16:0-PC+blood 0 0 0.525470085 yes serum_fattyacid serum_phospholipids 0.00876 0.0358 up no no no up no 16:0+blood 14:0/18:0-PC+blood 0 0 0.584273504 yes serum_fattyacid serum_phospholipids 0.00876 0.00289 up no no up up no 16:0+blood 14:0/18:2-PC+blood 0 0 0.418119658 yes serum_fattyacid serum_phospholipids 0.00876 0.102 up no no no up no 16:0+blood 14:0+blood 0.712781955 0 0.617094017 yes yes serum_fattyacid serum_fattyacid 0.00876 0.00572 up no no up no dn 16:0+blood Adipocytokine signaling pathway -0.471929825 0 0 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:0+blood Arginine and proline metabolism 0 0 0.421538462 yes serum_fattyacid kegg 0.00876 NA up no no no up no 16:0+blood Bifidobacterium 0 -0.496627929 0 yes acetate-producing serum_fattyacid Genus 0.00876 0.105 up no no no dn no 16:0+blood Biosynthesis of cofactors 0 -0.617647059 0 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:0+blood Central carbon metabolism in cancer 0.578947368 0 0 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:0+blood Cytosolic DNA-sensing pathway -0.505263158 0 0 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:0+blood Focal adhesion 0 0 -0.423076923 yes serum_fattyacid kegg 0.00876 NA up no no no up up 16:0+blood FoxO signaling pathway 0 0 -0.483076923 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:0+blood "Glycine, serine and threonine metabolism" 0 -0.805882353 0 yes serum_fattyacid kegg 0.00876 NA up no no no up no 16:0+blood Hippo signaling pathway 0 0 -0.415384615 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:0+blood Kaposi sarcoma-associated herpesvirus infection -0.578947368 0 0 yes serum_fattyacid kegg 0.00876 NA up no no no no dn 16:0+blood Leukocyte transendothelial migration 0 0 -0.400769231 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:0+blood Lipid and atherosclerosis 0.503508772 0 0 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:0+blood Longevity regulating pathway - multiple species 0.550877193 0 0 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:0+blood mTOR signaling pathway 0 0 0.408461538 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:0+blood Porphyrin and chlorophyll metabolism 0 -0.764705882 0 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:0+blood Progesterone-mediated oocyte maturation 0.505263158 0 0 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:0+blood Purine metabolism 0 -0.682352941 0 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:0+blood Shigellosis -0.585964912 0 0 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:0+blood Sphingolipid signaling pathway 0 0 -0.449230769 yes serum_fattyacid kegg 0.00876 NA up no no no no no 16:1-LPC+blood 14:0-LPC+blood 0 0 0.684786325 serum_phospholipids serum_phospholipids 0.0241 0.00689 no up no up up no 16:1-LPC+blood 14:0/16:0-PC+blood 0 0 0.555555556 serum_phospholipids serum_phospholipids 0.0241 0.0358 no up no no up no 16:1-LPC+blood 14:0/18:0-PC+blood 0 0 0.600683761 serum_phospholipids serum_phospholipids 0.0241 0.00289 no up no up up no 16:1-LPC+blood 14:0/18:2-PC+blood 0 0 0.494700855 serum_phospholipids serum_phospholipids 0.0241 0.102 no up no no up no 16:1-LPC+blood 14:0+blood 0 0 0.561709402 yes serum_phospholipids serum_fattyacid 0.0241 0.00572 no up no up no dn 16:1-LPC+blood 14:1/18:2-PG+blood 0 0 0.541196581 serum_phospholipids serum_phospholipids 0.0241 0.00259 no up no no up up 16:1-LPC+blood 16:0-LPC+blood 0 0 0.485811966 serum_phospholipids serum_phospholipids 0.0241 0.00456 no up no up up no 16:1-LPC+blood 16:0-LPE+blood 0 0.600490196 0 serum_phospholipids serum_phospholipids 0.0241 0.0711 no up no up up no 16:1-LPC+blood 16:0/16:0-PI+blood 0 0 0.555555556 serum_phospholipids serum_phospholipids 0.0241 0.358 no up no no no no 16:1-LPC+blood 16:0/16:1-PC+blood 0 0 0.608888889 serum_phospholipids serum_phospholipids 0.0241 0.00283 no up no up up no 16:1-LPC+blood 16:0/16:1-PI+blood 0 0 0.653333333 serum_phospholipids serum_phospholipids 0.0241 0.262 no up no no no no 16:1-LPC+blood 16:0/18:2-PI+blood 0 0 0.516581197 serum_phospholipids serum_phospholipids 0.0241 0.269 no up no no no no 16:1-LPC+blood 16:0/18:3-PC+blood 0 0 0.537094017 serum_phospholipids serum_phospholipids 0.0241 0.00216 no up no no up up 16:1-LPC+blood 16:0/20:4-PI+blood 0 0 0.550769231 serum_phospholipids serum_phospholipids 0.0241 0.558 no up no no no no 16:1-LPC+blood 16:0+blood 0 0 0.673162393 yes serum_phospholipids serum_fattyacid 0.0241 0.00876 no up no up no no 16:1-LPC+blood 16:1+blood 0 0 0.42017094 yes serum_phospholipids serum_fattyacid 0.0241 0.0186 no up no no no dn 16:1/16:0-PC+blood 14:0-LPC+blood 0 -0.575980392 -0.48991453 serum_phospholipids serum_phospholipids 0.0215 0.00689 no up up up up no 16:1/16:0-PC+blood 14:0/18:0-PC+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.0215 0.00289 no up up up up no 16:1/16:0-PC+blood 14:0/18:2-PC+blood 0 0 -0.527521368 serum_phospholipids serum_phospholipids 0.0215 0.102 no up up no up no 16:1/16:0-PC+blood 14:0/20:4-PC+blood 0 0 -0.612991453 serum_phospholipids serum_phospholipids 0.0215 0.486 no up up no no no 16:1/16:0-PC+blood 14:1/18:2-PG+blood 0 0 -0.579487179 serum_phospholipids serum_phospholipids 0.0215 0.00259 no up up no up up 16:1/16:0-PC+blood 16:0-LPC+blood 0 0 -0.505641026 serum_phospholipids serum_phospholipids 0.0215 0.00456 no up up up up no 16:1/16:0-PC+blood 16:0/14:0-PC+blood 0.720300752 0 0.693675214 serum_phospholipids serum_phospholipids 0.0215 0.0206 no up up no up up 16:1/16:0-PC+blood 16:0/16:0-PC+blood 0.633082707 0 0.625299145 serum_phospholipids serum_phospholipids 0.0215 0.00079 no up up no up up 16:1/16:0-PC+blood 16:0/16:0-PI+blood 0 -0.590686275 0 serum_phospholipids serum_phospholipids 0.0215 0.358 no up up no no no 16:1/16:0-PC+blood 16:0/16:1-PI+blood -0.542857143 -0.495098039 0 serum_phospholipids serum_phospholipids 0.0215 0.262 no up up no no no 16:1/16:0-PC+blood 16:0/18:0-PC+blood 0.470676692 0 0 serum_phospholipids serum_phospholipids 0.0215 0.521 no up up no no no 16:1/16:0-PC+blood 16:0/18:1-PC+blood 0.828571429 0.700980392 0.541880342 serum_phospholipids serum_phospholipids 0.0215 6.15E-07 no up up up up up 16:1/16:0-PC+blood 16:0/18:2-PC+blood 0.816541353 0.617647059 0.816752137 serum_phospholipids serum_phospholipids 0.0215 3.24E-06 no up up no up up 16:1/16:0-PC+blood 16:0/20:3-PC+blood 0.581954887 0 0 serum_phospholipids serum_phospholipids 0.0215 5.43E-06 no up up no up up 16:1/16:0-PC+blood 16:0/20:4-PC+blood 0.593984962 0.585784314 0.478974359 serum_phospholipids serum_phospholipids 0.0215 0.0262 no up up no up no 16:1/16:0-PC+blood 16:0/20:4-PI+blood -0.460150376 0 0 serum_phospholipids serum_phospholipids 0.0215 0.558 no up up no no no 16:1/16:0-PC+blood 16:0/22:0-PE+blood 0 0.544117647 0 serum_phospholipids serum_phospholipids 0.0215 0.00839 no up up dn no up 16:1/16:0-PC+blood 16:0/22:6-PC+blood 0.711278195 0.784313725 0.741538462 serum_phospholipids serum_phospholipids 0.0215 4.53E-05 no up up no up up 16:1/16:0-PC+blood Alzheimer disease 0 0 -0.465384615 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:0-PC+blood Amyotrophic lateral sclerosis 0 0 -0.510769231 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:0-PC+blood Calcium signaling pathway 0 0 -0.413846154 serum_phospholipids kegg 0.0215 NA no up up no up up 16:1/16:0-PC+blood Carbon metabolism 0 0 0.473846154 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:0-PC+blood Cardiac muscle contraction 0 0 -0.490769231 serum_phospholipids kegg 0.0215 NA no up up no no up 16:1/16:0-PC+blood Central carbon metabolism in cancer 0 -0.570588235 0 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:0-PC+blood Colorectal cancer 0 -0.526470588 0 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:0-PC+blood Cytokine-cytokine receptor interaction 0 0.523529412 0 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:0-PC+blood Diabetic cardiomyopathy 0 0 -0.435384615 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:0-PC+blood Huntington disease 0 0 -0.471538462 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:0-PC+blood IL-17 signaling pathway 0 0 0.446923077 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:0-PC+blood L-Tryptophan+stool 0 0 0.452631579 serum_phospholipids stool_cometabolism 0.0215 0.557 no up up no no no 16:1/16:0-PC+blood Lysosome 0 0 0.444615385 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:0-PC+blood Non-alcoholic fatty liver disease 0 0 -0.535384615 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:0-PC+blood Oxidative phosphorylation 0 0 -0.416923077 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:0-PC+blood Prevotella -0.521065478 0 0 acetate-producing serum_phospholipids Genus 0.0215 0.287 no up up no no no 16:1/16:0-PC+blood Prion disease 0 0 -0.450769231 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:0-PC+blood Renal cell carcinoma 0 -0.611764706 0 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:0-PC+blood Thyroid hormone signaling pathway 0 0 -0.41 serum_phospholipids kegg 0.0215 NA no up up no no no 16:1/16:1-PC+blood 14:0-LPC+blood -0.45112782 0 0 serum_phospholipids serum_phospholipids 0.0177 0.00689 no no up up up no 16:1/16:1-PC+blood 16:0/14:0-PC+blood 0.648120301 0 0.574700855 serum_phospholipids serum_phospholipids 0.0177 0.0206 no no up no up up 16:1/16:1-PC+blood 16:0/16:0-PC+blood 0.676691729 0 0.597264957 serum_phospholipids serum_phospholipids 0.0177 0.00079 no no up no up up 16:1/16:1-PC+blood 16:0/16:1-PI+blood -0.637593985 0 0 serum_phospholipids serum_phospholipids 0.0177 0.262 no no up no no no 16:1/16:1-PC+blood 16:0/18:0-PC+blood 0.577443609 0 0 serum_phospholipids serum_phospholipids 0.0177 0.521 no no up no no no 16:1/16:1-PC+blood 16:0/18:1-PC+blood 0.786466165 0 0.558974359 serum_phospholipids serum_phospholipids 0.0177 6.15E-07 no no up up up up 16:1/16:1-PC+blood 16:0/18:2-PC+blood 0.583458647 0 0.576752137 serum_phospholipids serum_phospholipids 0.0177 3.24E-06 no no up no up up 16:1/16:1-PC+blood 16:0/18:2-PI+blood -0.535338346 0 0 serum_phospholipids serum_phospholipids 0.0177 0.269 no no up no no no 16:1/16:1-PC+blood 16:0/20:3-PC+blood 0.481203008 0 0 serum_phospholipids serum_phospholipids 0.0177 5.43E-06 no no up no up up 16:1/16:1-PC+blood 16:0/20:4-PC+blood 0.616541353 0.485294118 0 serum_phospholipids serum_phospholipids 0.0177 0.0262 no no up no up no 16:1/16:1-PC+blood 16:0/20:4-PI+blood -0.467669173 0 0 serum_phospholipids serum_phospholipids 0.0177 0.558 no no up no no no 16:1/16:1-PC+blood 16:0/20:5-PG+blood 0.485714286 0 0 serum_phospholipids serum_phospholipids 0.0177 0.00656 no no up no up no 16:1/16:1-PC+blood 16:0/22:6-PC+blood 0.590977444 0.588235294 0.472136752 serum_phospholipids serum_phospholipids 0.0177 4.53E-05 no no up no up up 16:1/16:1-PC+blood 16:1/16:0-PC+blood 0.867669173 0.68627451 0.803760684 serum_phospholipids serum_phospholipids 0.0177 0.0215 no no up no up up 16:1/16:1-PC+blood 16:1+blood 0 0 0.44 yes serum_phospholipids serum_fattyacid 0.0177 0.0186 no no up no no dn 16:1/16:1-PC+blood Arginine and proline metabolism 0 0 0.474615385 serum_phospholipids kegg 0.0177 NA no no up no up no 16:1/16:1-PC+blood Axon guidance 0 -0.597058824 0 serum_phospholipids kegg 0.0177 NA no no up no up up 16:1/16:1-PC+blood Bacteroides 0 0.517156863 0 LPS-producing serum_phospholipids Genus 0.0177 0.000267 no no up dn dn up 16:1/16:1-PC+blood Butyric acid+stool 0 0 -0.493233083 yes serum_phospholipids stool_scfa 0.0177 0.102 no no up dn no no 16:1/16:1-PC+blood Calcium signaling pathway 0 -0.502941176 0 serum_phospholipids kegg 0.0177 NA no no up no up up 16:1/16:1-PC+blood Cell cycle 0 0 -0.436923077 serum_phospholipids kegg 0.0177 NA no no up no no no 16:1/16:1-PC+blood Colorectal cancer 0 -0.517647059 0 serum_phospholipids kegg 0.0177 NA no no up no no no 16:1/16:1-PC+blood Cytokine-cytokine receptor interaction 0 0.655882353 0 serum_phospholipids kegg 0.0177 NA no no up no no no 16:1/16:1-PC+blood Faecalibacterium 0 0 -0.401778088 butyrate-producing serum_phospholipids Genus 0.0177 0.0039 no no up no dn dn 16:1/16:1-PC+blood Ferroptosis 0 0 0.415384615 serum_phospholipids kegg 0.0177 NA no no up no no no 16:1/16:1-PC+blood GABAergic synapse 0 0 0.54 serum_phospholipids kegg 0.0177 NA no no up no up up 16:1/16:1-PC+blood Gastric cancer 0 -0.552941176 0 serum_phospholipids kegg 0.0177 NA no no up no no no 16:1/16:1-PC+blood IL-17 signaling pathway 0 0 0.472307692 serum_phospholipids kegg 0.0177 NA no no up no no no 16:1/16:1-PC+blood Malaria 0 0 0.457692308 serum_phospholipids kegg 0.0177 NA no no up no no no 16:1/16:1-PC+blood Mitophagy - animal -0.49122807 0 0 serum_phospholipids kegg 0.0177 NA no no up no no no 16:1/16:1-PC+blood Prevotella -0.592351309 0 0 acetate-producing serum_phospholipids Genus 0.0177 0.287 no no up no no no 16:1/16:1-PC+blood Proteoglycans in cancer -0.489473684 0 0 serum_phospholipids kegg 0.0177 NA no no up no no no 16:1/16:1-PC+blood Signaling pathways regulating pluripotency of stem cells 0 -0.582352941 0 serum_phospholipids kegg 0.0177 NA no no up no no no 16:1/16:1-PC+blood Slackia 0 0 -0.44367365 serum_phospholipids Genus 0.0177 0.94 no no up no no no 16:1/16:1-PC+blood Systemic lupus erythematosus 0.50877193 0 0 serum_phospholipids kegg 0.0177 NA no no up no no no 16:1/16:1-PC+blood Tuberculosis 0.468421053 0 0 serum_phospholipids kegg 0.0177 NA no no up no no dn 16:1/16:1-PC+blood Ubiquitin mediated proteolysis -0.463157895 0 0 serum_phospholipids kegg 0.0177 NA no no up no no no 16:1/18:1-PG+blood 11-HETE+blood 0 0.587916498 0 serum_phospholipids serum_ARA 3.21E-05 0.464 no up up no no no 16:1/18:1-PG+blood 12-ketoDCA+blood 0 -0.490684079 0 serum_phospholipids serum_bileacids 3.21E-05 0.517 no up up no no no 16:1/18:1-PG+blood 13-HODE+blood 0 0 -0.444786325 serum_phospholipids serum_ARA 3.21E-05 0.32 no up up no no no 16:1/18:1-PG+blood 14:0-LPC+blood -0.669172932 0 0 serum_phospholipids serum_phospholipids 3.21E-05 0.00689 no up up up up no 16:1/18:1-PG+blood 14:0+blood -0.461654135 0 0 yes serum_phospholipids serum_fattyacid 3.21E-05 0.00572 no up up up no dn 16:1/18:1-PG+blood 14:1/18:2-PG+blood -0.473684211 0 0 serum_phospholipids serum_phospholipids 3.21E-05 0.00259 no up up no up up 16:1/18:1-PG+blood 16:0/16:1-PC+blood 0 0.514705882 0 serum_phospholipids serum_phospholipids 3.21E-05 0.00283 no up up up up no 16:1/18:1-PG+blood 16:0/16:1-PI+blood 0 0.634803922 0 serum_phospholipids serum_phospholipids 3.21E-05 0.262 no up up no no no 16:1/18:1-PG+blood 16:0/18:0-PS+blood 0 0 0.675213675 serum_phospholipids serum_phospholipids 3.21E-05 0.377 no up up no no no 16:1/18:1-PG+blood 16:0/18:1-PC+blood 0.571428571 0 0 serum_phospholipids serum_phospholipids 3.21E-05 6.15E-07 no up up up up up 16:1/18:1-PG+blood 16:0/18:1-PE+blood 0 0.487745098 0 serum_phospholipids serum_phospholipids 3.21E-05 0.000107 no up up up up no 16:1/18:1-PG+blood 16:0/18:2-PI+blood -0.587969925 0 0 serum_phospholipids serum_phospholipids 3.21E-05 0.269 no up up no no no 16:1/18:1-PG+blood 16:0/20:4-PI+blood -0.494736842 0 0 serum_phospholipids serum_phospholipids 3.21E-05 0.558 no up up no no no 16:1/18:1-PG+blood 16:0/20:5-PG+blood 0.729323308 0 0.56991453 serum_phospholipids serum_phospholipids 3.21E-05 0.00656 no up up no up no 16:1/18:1-PG+blood 16:1-LPC+blood 0 0 0.473504274 serum_phospholipids serum_phospholipids 3.21E-05 0.0241 no up up no up no 16:1/18:1-PG+blood 16:1/16:1-PC+blood 0.589473684 0 0 serum_phospholipids serum_phospholipids 3.21E-05 0.0177 no up up no no up 16:1/18:1-PG+blood 16:1+blood 0 0.514705882 0 yes serum_phospholipids serum_fattyacid 3.21E-05 0.0186 no up up no no dn 16:1/18:2-PG+blood 13-HODE+blood 0.509774436 0 -0.45982906 serum_phospholipids serum_ARA 1.40E-08 0.32 no up up no no no 16:1/18:2-PG+blood 16:0-LPE+blood -0.532330827 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.0711 no up up up up no 16:1/18:2-PG+blood 16:0/14:0-PC+blood 0.472180451 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.0206 no up up no up up 16:1/18:2-PG+blood 16:0/16:1-PI+blood -0.578947368 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.262 no up up no no no 16:1/18:2-PG+blood 16:0/18:0-PS+blood 0 0 0.427008547 serum_phospholipids serum_phospholipids 1.40E-08 0.377 no up up no no no 16:1/18:2-PG+blood 16:0/18:1-PC+blood 0.610526316 0 0 serum_phospholipids serum_phospholipids 1.40E-08 6.15E-07 no up up up up up 16:1/18:2-PG+blood 16:0/18:1-PE+blood -0.455639098 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.000107 no up up up up no 16:1/18:2-PG+blood 16:0/18:2-PC+blood 0.584962406 0 0 serum_phospholipids serum_phospholipids 1.40E-08 3.24E-06 no up up no up up 16:1/18:2-PG+blood 16:0/18:2-PI+blood -0.445112782 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.269 no up up no no no 16:1/18:2-PG+blood 16:0/20:3-PC+blood 0.633082707 0 0 serum_phospholipids serum_phospholipids 1.40E-08 5.43E-06 no up up no up up 16:1/18:2-PG+blood 16:0/20:4-PC+blood 0.496240602 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.0262 no up up no up no 16:1/18:2-PG+blood 16:0/20:4-PI+blood -0.520300752 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.558 no up up no no no 16:1/18:2-PG+blood 16:0/20:5-PG+blood 0.62556391 0 0.695726496 serum_phospholipids serum_phospholipids 1.40E-08 0.00656 no up up no up no 16:1/18:2-PG+blood 16:0+blood 0 0.549019608 0 yes serum_phospholipids serum_fattyacid 1.40E-08 0.00876 no up up up no no 16:1/18:2-PG+blood 16:1/16:0-PC+blood 0.544360902 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.0215 no up up no up up 16:1/18:2-PG+blood 16:1/16:1-PC+blood 0.596992481 0 0 serum_phospholipids serum_phospholipids 1.40E-08 0.0177 no up up no no up 16:1/18:2-PG+blood 16:1/18:1-PG+blood 0.77593985 0.600490196 0.736752137 serum_phospholipids serum_phospholipids 1.40E-08 3.21E-05 no up up no up up 16:1/18:2-PG+blood Akkermansia 0 0 -0.459096253 acetate-producing serum_phospholipids Genus 1.40E-08 0.23 no up up no no no 16:1/18:2-PG+blood Allograft rejection 0 0.544117647 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Amoebiasis 0 0.529411765 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Apelin signaling pathway 0 -0.508823529 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Apoptosis 0 0.720588235 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Autoimmune thyroid disease 0 0.544117647 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Bacteroides 0 -0.553921569 0 LPS-producing serum_phospholipids Genus 1.40E-08 0.000267 no up up dn dn up 16:1/18:2-PG+blood Biosynthesis of cofactors 0 -0.697058824 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood C-type lectin receptor signaling pathway 0 0.541176471 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Cell adhesion molecules 0 0.532352941 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Cell cycle 0 -0.520588235 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Cellular senescence 0 0.597058824 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Chagas disease 0 0.529411765 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood EGFR tyrosine kinase inhibitor resistance 0 -0.5 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Endocytosis 0 0.561764706 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Epithelial cell signaling in Helicobacter pylori infection 0 0.505882353 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Fc epsilon RI signaling pathway 0 0.511764706 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood GCDCA+stool 0 0.681818182 0 yes serum_phospholipids stool_bileacids 1.40E-08 0.0471 no up up no dn no 16:1/18:2-PG+blood "Glycine, serine and threonine metabolism" 0 -0.623529412 0 serum_phospholipids kegg 1.40E-08 NA no up up no up no 16:1/18:2-PG+blood Graft-versus-host disease 0 0.544117647 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Human papillomavirus infection 0 0.520588235 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood IL-17 signaling pathway 0 0.529411765 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Influenza A 0 0.514705882 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood mTOR signaling pathway 0 -0.505882353 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Natural killer cell mediated cytotoxicity 0 0.579411765 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood NOD-like receptor signaling pathway 0 0 -0.449230769 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Osteoclast differentiation 0 0.605882353 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Parabacteroides 0.466165414 0 0 serum_phospholipids Genus 1.40E-08 4.19E-05 no up up no up up 16:1/18:2-PG+blood Pertussis 0 0.517647059 0 serum_phospholipids kegg 1.40E-08 NA no up up no no dn 16:1/18:2-PG+blood Primary immunodeficiency 0 -0.517647059 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Prolactin signaling pathway 0 0.567647059 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Protein processing in endoplasmic reticulum 0 -0.511764706 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Purine metabolism 0 -0.511764706 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Ras signaling pathway 0 -0.638235294 0.417692308 yes serum_phospholipids kegg 1.40E-08 NA no up up no up up 16:1/18:2-PG+blood RNA degradation 0 -0.535294118 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood RNA transport 0 -0.502941176 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Sphingolipid signaling pathway 0 0.508823529 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Toll-like receptor signaling pathway 0 0.552941176 0 yes serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Type I diabetes mellitus 0 0.544117647 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Viral carcinogenesis 0 0.552941176 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Viral myocarditis 0 0.567647059 0 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1/18:2-PG+blood Wnt signaling pathway 0 -0.547058824 0.41 serum_phospholipids kegg 1.40E-08 NA no up up no no no 16:1+blood 11-HETE+blood 0 0.490408396 0 yes serum_fattyacid serum_ARA 0.0186 0.464 no no dn no no no 16:1+blood 12-ketoDCA+blood 0 -0.579599987 0 yes serum_fattyacid serum_bileacids 0.0186 0.517 no no dn no no no 16:1+blood 13-HODE+blood 0.612030075 0 0 yes serum_fattyacid serum_ARA 0.0186 0.32 no no dn no no no 16:1+blood 14:0/18:0-PC+blood 0 0 0.629401709 yes serum_fattyacid serum_phospholipids 0.0186 0.00289 no no dn up up no 16:1+blood 14:0+blood 0.466165414 0 0.404444444 yes yes serum_fattyacid serum_fattyacid 0.0186 0.00572 no no dn up no dn 16:1+blood 16:0-LPE+blood 0 0.556372549 0 yes serum_fattyacid serum_phospholipids 0.0186 0.0711 no no dn up up no 16:1+blood 16:0/16:1-PC+blood 0 0 0.63008547 yes serum_fattyacid serum_phospholipids 0.0186 0.00283 no no dn up up no 16:1+blood 16:0/16:1-PI+blood 0 0 0.536410256 yes serum_fattyacid serum_phospholipids 0.0186 0.262 no no dn no no no 16:1+blood 16:0/18:0-PC+blood 0 0 -0.40991453 yes serum_fattyacid serum_phospholipids 0.0186 0.521 no no dn no no no 16:1+blood 16:0/18:0-PS+blood 0 0.595588235 0 yes serum_fattyacid serum_phospholipids 0.0186 0.377 no no dn no no no 16:1+blood 16:0/18:1-PC+blood 0 0 0.51042735 yes serum_fattyacid serum_phospholipids 0.0186 6.15E-07 no no dn up up up 16:1+blood 16:0/18:1-PE+blood 0 0.507352941 0.495384615 yes serum_fattyacid serum_phospholipids 0.0186 0.000107 no no dn up up no 16:1+blood 16:0/18:3-PC+blood 0 -0.487745098 0 yes serum_fattyacid serum_phospholipids 0.0186 0.00216 no no dn no up up 16:1+blood 16:0/20:4-PE+blood 0 0.642156863 0.42974359 yes serum_fattyacid serum_phospholipids 0.0186 0.00139 no no dn up up no 16:1+blood 16:0/22:0-PE+blood 0 0 -0.538461538 yes serum_fattyacid serum_phospholipids 0.0186 0.00839 no no dn dn no up 16:1+blood 16:0/22:6-PE+blood 0 0.620098039 0.418803419 yes serum_fattyacid serum_phospholipids 0.0186 0.000934 no no dn up up no 16:1+blood 16:0+blood 0.681203008 0 0.593846154 yes yes serum_fattyacid serum_fattyacid 0.0186 0.00876 no no dn up no no 16:1+blood AGE-RAGE signaling pathway in diabetic complications 0.533333333 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood AMPK signaling pathway -0.510526316 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Antigen processing and presentation 0 0 0.611538462 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Arginine and proline metabolism 0 0 0.497692308 yes serum_fattyacid kegg 0.0186 NA no no dn no up no 16:1+blood Biosynthesis of cofactors -0.568421053 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood C-type lectin receptor signaling pathway 0 0 0.41 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood cGMP-PKG signaling pathway 0.58245614 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Cholinergic synapse 0.529824561 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Cushing syndrome -0.459649123 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no up 16:1+blood Cytosolic DNA-sensing pathway 0 0 0.507692308 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Epithelial cell signaling in Helicobacter pylori infection 0 0 0.486153846 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Epstein-Barr virus infection 0 0 0.650769231 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Glioma 0.596491228 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood "Glycine, serine and threonine metabolism" -0.526315789 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no up no 16:1+blood HCA+stool 0.604395604 0 0 yes serum_fattyacid stool_bileacids 0.0186 0.155 no no dn no no no 16:1+blood Herpes simplex virus 1 infection 0 0 0.646153846 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Human cytomegalovirus infection 0 0 0.638461538 yes serum_fattyacid kegg 0.0186 NA no no dn no no dn 16:1+blood Human immunodeficiency virus 1 infection 0 0 0.675384615 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Human T-cell leukemia virus 1 infection 0 0 0.635384615 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood L-Tyrosine+stool 0 0 -0.50075188 yes serum_fattyacid stool_cometabolism 0.0186 0.44 no no dn no no no 16:1+blood Legionellosis 0 -0.523529412 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Leishmaniasis 0 -0.508823529 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Lipid and atherosclerosis 0.666666667 0 0.480769231 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Long-term potentiation 0.547368421 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no up 16:1+blood Measles 0 -0.511764706 0.430769231 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood NOD-like receptor signaling pathway 0.507017544 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Olfactory transduction 0.512280702 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Peroxisome 0.461403509 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Pertussis 0.536842105 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no dn 16:1+blood Porphyrin and chlorophyll metabolism -0.522807018 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood PPAR signaling pathway 0 0 0.48 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood TNF signaling pathway 0 0 0.47 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood Toll-like receptor signaling pathway 0 0 0.453076923 yes yes serum_fattyacid kegg 0.0186 NA no no dn no no no 16:1+blood VEGF signaling pathway 0.461403509 0 0 yes serum_fattyacid kegg 0.0186 NA no no dn no no no 17-HDOHE+blood 12-HEPE+blood 0 0.548529813 0 serum_ARA serum_ARA 0.62 0.312 no no no no no no 17-HDOHE+blood Butyricicoccus 0 0 0.426699929 butyrate-producing serum_ARA Genus 0.62 0.852 no no no no no no 17-HDOHE+blood Pyramidobacter 0 0 -0.48441412 serum_ARA Genus 0.62 0.45 no no no no no no 18:0-LPA+blood 11-HETE+blood -0.476087514 0 0 serum_phospholipids serum_ARA 0.0725 0.464 no dn no no no no 18:0-LPA+blood 15-HETE+blood 0 0 -0.480800243 serum_phospholipids serum_ARA 0.0725 0.819 no dn no no no no 18:0-LPA+blood 16:0-LPC+blood 0.445112782 0 0.515213675 serum_phospholipids serum_phospholipids 0.0725 0.00456 no dn no up up no 18:0-LPA+blood 16:0/14:0-PC+blood 0 0 -0.446153846 serum_phospholipids serum_phospholipids 0.0725 0.0206 no dn no no up up 18:0-LPA+blood 16:0/16:0-PC+blood 0 0 -0.417435897 serum_phospholipids serum_phospholipids 0.0725 0.00079 no dn no no up up 18:0-LPA+blood 16:0/20:4-PC+blood 0 0 -0.419487179 serum_phospholipids serum_phospholipids 0.0725 0.0262 no dn no no up no 18:0-LPA+blood 16:0/20:4-PE+blood 0.532330827 0 0 serum_phospholipids serum_phospholipids 0.0725 0.00139 no dn no up up no 18:0-LPA+blood 16:1-LPC+blood 0 0 0.513846154 serum_phospholipids serum_phospholipids 0.0725 0.0241 no dn no no up no 18:0-LPA+blood 16:1/16:0-PC+blood 0 0 -0.538461538 serum_phospholipids serum_phospholipids 0.0725 0.0215 no dn no no up up 18:0-LPA+blood 16:1/16:1-PC+blood 0 0 -0.506324786 serum_phospholipids serum_phospholipids 0.0725 0.0177 no dn no no no up 18:0-LPA+blood Alzheimer disease 0 0 0.442307692 serum_phospholipids kegg 0.0725 NA no dn no no no no 18:0-LPA+blood Cardiac muscle contraction 0 0 0.405384615 serum_phospholipids kegg 0.0725 NA no dn no no no up 18:0-LPA+blood CDCA+stool 0 0 0.518796992 serum_phospholipids stool_bileacids 0.0725 0.663 no dn no no no no 18:0-LPA+blood Glycolysis / Gluconeogenesis 0 0 -0.418461538 serum_phospholipids kegg 0.0725 NA no dn no no no no 18:0-LPA+blood HCA+stool 0 0 0.473684211 serum_phospholipids stool_bileacids 0.0725 0.155 no dn no no no no 18:0-LPA+blood HDCA+stool 0 0 -0.445112782 serum_phospholipids stool_bileacids 0.0725 0.176 no dn no no no no 18:0-LPA+blood Huntington disease 0 0 0.452307692 serum_phospholipids kegg 0.0725 NA no dn no no no no 18:0-LPA+blood L-Tryptophan+stool 0 0 -0.55037594 serum_phospholipids stool_cometabolism 0.0725 0.557 no dn no no no no 18:0-LPA+blood Phenylacetic acid+stool 0 0 -0.487218045 serum_phospholipids stool_cometabolism 0.0725 0.785 no dn no no no no 18:0-LPA+blood Prion disease 0 0 0.420769231 serum_phospholipids kegg 0.0725 NA no dn no no no no 18:0-LPC+blood 16:0-LPC+blood 0.542857143 0 0.47008547 serum_phospholipids serum_phospholipids 0.554 0.00456 no no no up up no 18:0-LPC+blood 16:0/16:0-PC+blood 0 -0.625 0 serum_phospholipids serum_phospholipids 0.554 0.00079 no no no no up up 18:0-LPC+blood 16:0/16:1-PC+blood -0.49924812 0 0 serum_phospholipids serum_phospholipids 0.554 0.00283 no no no up up no 18:0-LPC+blood 16:0/18:0-PC+blood 0 0 0.671794872 serum_phospholipids serum_phospholipids 0.554 0.521 no no no no no no 18:0-LPC+blood 16:0/18:1-PC+blood 0 -0.595588235 0 serum_phospholipids serum_phospholipids 0.554 6.15E-07 no no no up up up 18:0-LPC+blood 16:0/18:2-PC+blood 0 -0.644607843 0 serum_phospholipids serum_phospholipids 0.554 3.24E-06 no no no no up up 18:0-LPC+blood 16:0+blood 0 -0.541666667 0 yes serum_phospholipids serum_fattyacid 0.554 0.00876 no no no up no no 18:0-LPC+blood Adipocytokine signaling pathway -0.484210526 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Adlercreutzia 0 0 0.42154647 serum_phospholipids Genus 0.554 0.548 no no no no no no 18:0-LPC+blood Adrenergic signaling in cardiomyocytes 0 0.517647059 0 serum_phospholipids kegg 0.554 NA no no no no no up 18:0-LPC+blood Aldosterone synthesis and secretion 0.529824561 0.573529412 0 serum_phospholipids kegg 0.554 NA no no no no up up 18:0-LPC+blood Alistipes 0 0.587369822 0 serum_phospholipids Genus 0.554 0.0114 no no no no up no 18:0-LPC+blood Allograft rejection -0.592982456 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Amphetamine addiction 0.619298246 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood AMPK signaling pathway 0 0.576470588 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Antigen processing and presentation 0 0 -0.426153846 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Apoptosis -0.571929825 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Autoimmune thyroid disease -0.592982456 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Butyricimonas 0.618914319 0 0 butyrate-producing serum_phospholipids Genus 0.554 0.17 no no no no no no 18:0-LPC+blood Calcium signaling pathway 0 0.632352941 0 serum_phospholipids kegg 0.554 NA no no no no up up 18:0-LPC+blood Cell adhesion molecules -0.573684211 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Cell cycle 0.559649123 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Cellular senescence -0.547368421 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Central carbon metabolism in cancer 0 0.647058824 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Chemical carcinogenesis - receptor activation 0.484210526 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Circadian entrainment 0.459649123 0 0 serum_phospholipids kegg 0.554 NA no no no no up up 18:0-LPC+blood Cushing syndrome 0.473684211 0.544117647 0 serum_phospholipids kegg 0.554 NA no no no no no up 18:0-LPC+blood Cytosolic DNA-sensing pathway -0.533333333 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Dorea -0.565413534 0 0 serum_phospholipids Genus 0.554 0.00362 no no no up no dn 18:0-LPC+blood Endocrine resistance 0 0.517647059 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Endocytosis -0.538596491 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Epithelial cell signaling in Helicobacter pylori infection -0.559649123 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Estrogen signaling pathway 0.496491228 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Glucagon signaling pathway 0.642105263 0.564705882 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood "Glycine, serine and threonine metabolism" 0 0.5 0 serum_phospholipids kegg 0.554 NA no no no no up no 18:0-LPC+blood GnRH signaling pathway 0.49122807 0.523529412 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Graft-versus-host disease -0.592982456 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Human papillomavirus infection -0.545614035 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Inflammatory mediator regulation of TRP channels 0.584210526 0.602941176 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Influenza A -0.542105263 -0.535294118 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Insulin resistance 0 0 0.496923077 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Long-term potentiation 0.643859649 0 0 serum_phospholipids kegg 0.554 NA no no no no no up 18:0-LPC+blood Longevity regulating pathway - multiple species 0 0 -0.426153846 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Melanogenesis 0.505263158 0.608823529 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Methanobrevibacter 0 0 0.49421965 serum_phospholipids Genus 0.554 0.629 no no no no no no 18:0-LPC+blood Natural killer cell mediated cytotoxicity -0.526315789 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood NF-kappa B signaling pathway 0 0 0.403076923 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Oocyte meiosis 0.615789474 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood "Parathyroid hormone synthesis, secretion and action" 0 0.573529412 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Phagosome -0.542105263 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Prevotella 0 0 0.415602834 acetate-producing serum_phospholipids Genus 0.554 0.287 no no no no no no 18:0-LPC+blood Proteasome 0 0 -0.427692308 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Purine metabolism 0 0.547058824 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Regulation of actin cytoskeleton 0 0 -0.41 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Rheumatoid arthritis -0.587719298 -0.561764706 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Ribosome biogenesis in eukaryotes 0.503508772 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood RIG-I-like receptor signaling pathway 0 0 0.412307692 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood RNA degradation 0.456140351 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Salmonella infection 0 -0.65 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Staphylococcus aureus infection 0 -0.529411765 0 serum_phospholipids kegg 0.554 NA no no no up no no 18:0-LPC+blood Th1 and Th2 cell differentiation 0 -0.558823529 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Tight junction 0 0 -0.466923077 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Toxoplasmosis 0 -0.6 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Transcriptional misregulation in cancer 0 0 0.546923077 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Tuberculosis 0 -0.544117647 0 serum_phospholipids kegg 0.554 NA no no no no no dn 18:0-LPC+blood Type I diabetes mellitus -0.592982456 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Viral carcinogenesis -0.628070175 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPC+blood Viral myocarditis -0.621052632 0 0 serum_phospholipids kegg 0.554 NA no no no no no no 18:0-LPE+blood 16:0-LPE+blood 0.607518797 0.583333333 0.543247863 serum_phospholipids serum_phospholipids 0.491 0.0711 no no no up up no 18:0-LPE+blood 16:0/16:0-PC+blood 0 -0.578431373 0 serum_phospholipids serum_phospholipids 0.491 0.00079 no no no no up up 18:0-LPE+blood 16:0/16:0-PI+blood 0.45112782 0 0 serum_phospholipids serum_phospholipids 0.491 0.358 no no no no no no 18:0-LPE+blood 16:0/18:0-PS+blood 0.640601504 0 0 serum_phospholipids serum_phospholipids 0.491 0.377 no no no no no no 18:0-LPE+blood 16:0/18:1-PC+blood 0 -0.536764706 0 serum_phospholipids serum_phospholipids 0.491 6.15E-07 no no no up up up 18:0-LPE+blood 16:0/18:1-PE+blood 0.615037594 0 0 serum_phospholipids serum_phospholipids 0.491 0.000107 no no no up up no 18:0-LPE+blood 16:0/18:2-PC+blood -0.463157895 -0.490196078 0 serum_phospholipids serum_phospholipids 0.491 3.24E-06 no no no no up up 18:0-LPE+blood 16:0/20:3-PC+blood -0.532330827 0 0 serum_phospholipids serum_phospholipids 0.491 5.43E-06 no no no no up up 18:0-LPE+blood 16:0/20:4-PC+blood -0.50075188 0 0 serum_phospholipids serum_phospholipids 0.491 0.0262 no no no no up no 18:0-LPE+blood 16:0/20:4-PE+blood 0.702255639 0 0 serum_phospholipids serum_phospholipids 0.491 0.00139 no no no up up no 18:0-LPE+blood 16:0/22:0-PE+blood 0 -0.62745098 0 serum_phospholipids serum_phospholipids 0.491 0.00839 no no no dn no up 18:0-LPE+blood 16:0/22:6-PE+blood 0.688721805 0 0 serum_phospholipids serum_phospholipids 0.491 0.000934 no no no up up no 18:0-LPE+blood 16:1-LPC+blood 0 0.50245098 0 serum_phospholipids serum_phospholipids 0.491 0.0241 no no no no up no 18:0-LPE+blood 18:0-LPC+blood 0.598496241 0.732843137 0.464615385 serum_phospholipids serum_phospholipids 0.491 0.554 no no no no no no 18:0-LPE+blood Allograft rejection -0.547368421 0 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Amoebiasis 0 0 0.426153846 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Asthma -0.457894737 -0.541176471 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Autoimmune thyroid disease -0.547368421 0 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Cell adhesion molecules -0.487719298 0 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Cellular senescence -0.545614035 0 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Cytosolic DNA-sensing pathway -0.592982456 0 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Fusobacterium 0 0.561103984 0 serum_phospholipids Genus 0.491 0.628 no no no no no no 18:0-LPE+blood Graft-versus-host disease -0.547368421 0 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Hematopoietic cell lineage 0 -0.579411765 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Hepatitis B 0 0 0.414615385 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Human cytomegalovirus infection -0.463157895 0 0 serum_phospholipids kegg 0.491 NA no no no no no dn 18:0-LPE+blood Human papillomavirus infection -0.492982456 0 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Inflammatory bowel disease 0 -0.544117647 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Influenza A -0.485964912 0 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Kaposi sarcoma-associated herpesvirus infection -0.457894737 0 0 serum_phospholipids kegg 0.491 NA no no no no no dn 18:0-LPE+blood L-Phenylalanine+stool 0 0 -0.557894737 serum_phospholipids stool_cometabolism 0.491 0.398 no no no no no no 18:0-LPE+blood L-Tyrosine+stool 0 0 -0.541353383 serum_phospholipids stool_cometabolism 0.491 0.44 no no no no no no 18:0-LPE+blood Longevity regulating pathway - multiple species 0.59122807 0 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Malaria 0 0.682352941 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood MAPK signaling pathway 0.68245614 0 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Olfactory transduction 0.48245614 0 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Propionic acid+stool 0 0.609090909 0 yes serum_phospholipids stool_scfa 0.491 0.0436 no no no dn no up 18:0-LPE+blood Proteasome 0 0 -0.526153846 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Rheumatoid arthritis -0.5 0 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Th1 and Th2 cell differentiation -0.475438596 -0.588235294 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Th17 cell differentiation 0 -0.529411765 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Toxoplasmosis 0 -0.602941176 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Transcriptional misregulation in cancer 0 0 0.490769231 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Type I diabetes mellitus -0.547368421 0 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Viral carcinogenesis -0.535087719 0 0.416923077 serum_phospholipids kegg 0.491 NA no no no no no no 18:0-LPE+blood Viral myocarditis -0.536842105 0 0 serum_phospholipids kegg 0.491 NA no no no no no no 18:0/16:0-PC+blood 13-HODE+blood 0 0.517156863 0 serum_phospholipids serum_ARA 9.64E-07 0.32 up up up no no no 18:0/16:0-PC+blood 14:0/18:0-PC+blood 0 0 0.558974359 serum_phospholipids serum_phospholipids 9.64E-07 0.00289 up up up up up no 18:0/16:0-PC+blood 14:0/20:4-PC+blood 0 0 -0.414017094 serum_phospholipids serum_phospholipids 9.64E-07 0.486 up up up no no no 18:0/16:0-PC+blood 16:0/14:0-PC+blood 0.631578947 0.588235294 0 serum_phospholipids serum_phospholipids 9.64E-07 0.0206 up up up no up up 18:0/16:0-PC+blood 16:0/16:0-PC+blood 0.606015038 0.68872549 0 serum_phospholipids serum_phospholipids 9.64E-07 0.00079 up up up no up up 18:0/16:0-PC+blood 16:0/16:0-PI+blood -0.556390977 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.358 up up up no no no 18:0/16:0-PC+blood 16:0/16:1-PC+blood 0 0 0.528888889 serum_phospholipids serum_phospholipids 9.64E-07 0.00283 up up up up up no 18:0/16:0-PC+blood 16:0/16:1-PI+blood -0.690225564 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.262 up up up no no no 18:0/16:0-PC+blood 16:0/18:0-PC+blood 0.488721805 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.521 up up up no no no 18:0/16:0-PC+blood 16:0/18:1-PC+blood 0.984962406 0.973039216 0.99042735 serum_phospholipids serum_phospholipids 9.64E-07 6.15E-07 up up up up up up 18:0/16:0-PC+blood 16:0/18:1-PE+blood -0.521804511 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.000107 up up up up up no 18:0/16:0-PC+blood 16:0/18:2-PC+blood 0.833082707 0.909313725 0.712136752 serum_phospholipids serum_phospholipids 9.64E-07 3.24E-06 up up up no up up 18:0/16:0-PC+blood 16:0/18:2-PI+blood -0.685714286 0 0 serum_phospholipids serum_phospholipids 9.64E-07 0.269 up up up no no no 18:0/16:0-PC+blood 16:0/20:3-PC+blood 0.506766917 0.566176471 0.551452991 serum_phospholipids serum_phospholipids 9.64E-07 5.43E-06 up up up no up up 18:0/16:0-PC+blood 16:0/20:4-PC+blood 0.712781955 0.617647059 0 serum_phospholipids serum_phospholipids 9.64E-07 0.0262 up up up no up no 18:0/16:0-PC+blood 16:0/20:4-PI+blood -0.637593985 -0.536764706 0 serum_phospholipids serum_phospholipids 9.64E-07 0.558 up up up no no no 18:0/16:0-PC+blood 16:0/22:6-PC+blood 0.517293233 0.588235294 0.443418803 serum_phospholipids serum_phospholipids 9.64E-07 4.53E-05 up up up no up up 18:0/16:0-PC+blood 16:0+blood 0 0 0.433162393 yes serum_phospholipids serum_fattyacid 9.64E-07 0.00876 up up up up no no 18:0/16:0-PC+blood 16:1/16:0-PC+blood 0.837593985 0.705882353 0.545299145 serum_phospholipids serum_phospholipids 9.64E-07 0.0215 up up up no up up 18:0/16:0-PC+blood 16:1/16:1-PC+blood 0.819548872 0 0.548717949 serum_phospholipids serum_phospholipids 9.64E-07 0.0177 up up up no no up 18:0/16:0-PC+blood 16:1/18:1-PG+blood 0.560902256 0 0 serum_phospholipids serum_phospholipids 9.64E-07 3.21E-05 up up up no up up 18:0/16:0-PC+blood 16:1/18:2-PG+blood 0.57593985 0 0 serum_phospholipids serum_phospholipids 9.64E-07 1.40E-08 up up up no up up 18:0/16:0-PC+blood 16:1+blood 0 0 0.51042735 yes serum_phospholipids serum_fattyacid 9.64E-07 0.0186 up up up no no dn 18:0/16:0-PC+blood 18:0-LPC+blood 0 -0.539215686 0 serum_phospholipids serum_phospholipids 9.64E-07 0.554 up up up no no no 18:0/16:0-PC+blood 18:0-LPE+blood 0 -0.495098039 0 serum_phospholipids serum_phospholipids 9.64E-07 0.491 up up up no no no 18:0/16:0-PC+blood Adherens junction 0 0 -0.466153846 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Adrenergic signaling in cardiomyocytes 0 -0.55 0 serum_phospholipids kegg 9.64E-07 NA up up up no no up 18:0/16:0-PC+blood Alistipes 0.453588135 0 0 serum_phospholipids Genus 9.64E-07 0.0114 up up up no up no 18:0/16:0-PC+blood AMPK signaling pathway 0 -0.676470588 0 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Apelin signaling pathway 0 0 0.400769231 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Arginine and proline metabolism 0 0 0.438461538 serum_phospholipids kegg 9.64E-07 NA up up up no up no 18:0/16:0-PC+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.491538462 serum_phospholipids kegg 9.64E-07 NA up up up no up up 18:0/16:0-PC+blood Central carbon metabolism in cancer 0 -0.717647059 0 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Cytokine-cytokine receptor interaction 0 0 -0.412307692 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Dilated cardiomyopathy 0 0 -0.566153846 serum_phospholipids kegg 9.64E-07 NA up up up no up up 18:0/16:0-PC+blood EGFR tyrosine kinase inhibitor resistance 0 0 0.469230769 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Epstein-Barr virus infection 0 0 0.458461538 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Focal adhesion 0 0 -0.439230769 serum_phospholipids kegg 9.64E-07 NA up up up no up up 18:0/16:0-PC+blood Fusobacterium 0 -0.653861011 0 serum_phospholipids Genus 9.64E-07 0.628 up up up no no no 18:0/16:0-PC+blood Gap junction 0 0 -0.473076923 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Gastric acid secretion 0 0 -0.517692308 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood GCA+stool 0 0 0.553383459 serum_phospholipids stool_bileacids 9.64E-07 0.0809 up up up no no no 18:0/16:0-PC+blood "Glycine, serine and threonine metabolism" 0 -0.564705882 0 serum_phospholipids kegg 9.64E-07 NA up up up no up no 18:0/16:0-PC+blood HDCA+stool 0.626373626 0 0 serum_phospholipids stool_bileacids 9.64E-07 0.176 up up up no no no 18:0/16:0-PC+blood Hepatocellular carcinoma 0 0 -0.489230769 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood HIF-1 signaling pathway 0 0 0.496923077 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Hippo signaling pathway 0 0 -0.487692308 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Human immunodeficiency virus 1 infection 0 0 0.446153846 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Human T-cell leukemia virus 1 infection 0 0 0.413076923 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Hypertrophic cardiomyopathy 0 0 -0.510769231 serum_phospholipids kegg 9.64E-07 NA up up up no up up 18:0/16:0-PC+blood Insulin signaling pathway 0 0 0.438461538 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood LCA+stool 0.576923077 0 0 serum_phospholipids stool_bileacids 9.64E-07 0.314 up up up no no no 18:0/16:0-PC+blood mTOR signaling pathway 0 -0.520588235 0.563846154 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Phenylacetic acid+stool 0 -0.627272727 0 serum_phospholipids stool_cometabolism 9.64E-07 0.785 up up up no no no 18:0/16:0-PC+blood Platelet activation 0 0 -0.511538462 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Proteasome 0 0 0.595384615 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Rap1 signaling pathway 0 0 -0.512307692 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Renal cell carcinoma 0 -0.502941176 0 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood TCA+stool -0.718019936 0 0.463157895 serum_phospholipids stool_bileacids 9.64E-07 0.458 up up up no no no 18:0/16:0-PC+blood Th1 and Th2 cell differentiation 0 0.535294118 0 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Thyroid hormone signaling pathway 0 0 -0.506923077 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Toxoplasmosis 0 0.558823529 0 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Vibrio cholerae infection 0 0 -0.458461538 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/16:0-PC+blood Viral myocarditis 0 0.5 0 serum_phospholipids kegg 9.64E-07 NA up up up no no no 18:0/18:0-PC+blood 14:0/18:0-PC+blood 0 0.539215686 0 serum_phospholipids serum_phospholipids 0.426 0.00289 no no no up up no 18:0/18:0-PC+blood 16:0/16:1-PC+blood 0 0.585784314 0 serum_phospholipids serum_phospholipids 0.426 0.00283 no no no up up no 18:0/18:0-PC+blood 16:0/16:1-PI+blood 0 0.615196078 0 serum_phospholipids serum_phospholipids 0.426 0.262 no no no no no no 18:0/18:0-PC+blood 16:0/18:0-PC+blood 0.54887218 0 0.522735043 serum_phospholipids serum_phospholipids 0.426 0.521 no no no no no no 18:0/18:0-PC+blood 16:0/20:3-PC+blood 0 0.546568627 0 serum_phospholipids serum_phospholipids 0.426 5.43E-06 no no no no up up 18:0/18:0-PC+blood 16:1-LPC+blood -0.54887218 0 0 serum_phospholipids serum_phospholipids 0.426 0.0241 no no no no up no 18:0/18:0-PC+blood Arrhythmogenic right ventricular cardiomyopathy 0 0.5 0 serum_phospholipids kegg 0.426 NA no no no no up up 18:0/18:0-PC+blood Fusobacterium 0 -0.51244456 0 serum_phospholipids Genus 0.426 0.628 no no no no no no 18:0/18:0-PC+blood GCDCA+stool 0 0 0.452631579 yes serum_phospholipids stool_bileacids 0.426 0.0471 no no no no dn no 18:0/18:0-PC+blood GDCA+stool 0 0 0.597892244 serum_phospholipids stool_bileacids 0.426 0.656 no no no no no no 18:0/18:0-PC+blood "Growth hormone synthesis, secretion and action" 0 -0.608823529 0 serum_phospholipids kegg 0.426 NA no no no no no no 18:0/18:0-PC+blood Hippo signaling pathway 0 0.555882353 0 serum_phospholipids kegg 0.426 NA no no no no no no 18:0/18:0-PC+blood nutriCA+stool 0 0.789024032 0 serum_phospholipids stool_bileacids 0.426 0.481 no no no no no no 18:0/18:0-PC+blood Propionic acid+stool 0 0 -0.484210526 yes serum_phospholipids stool_scfa 0.426 0.0436 no no no dn no up 18:0/18:0-PC+blood Ruminococcus 0 0.495098039 0 acetate-producing serum_phospholipids Genus 0.426 0.335 no no no no no no 18:0/18:0-PC+blood TCA+stool 0 0 0.481203008 serum_phospholipids stool_bileacids 0.426 0.458 no no no no no no 18:0/18:0-PE+blood 12-HEPE+blood 0 0 -0.48938247 serum_phospholipids serum_ARA 0.00896 0.312 up up no no no no 18:0/18:0-PE+blood 12-ketoDCA+blood 0 -0.497270443 0 serum_phospholipids serum_bileacids 0.00896 0.517 up up no no no no 18:0/18:0-PE+blood "12,13-EPOME+blood" 0 0.574965901 0 serum_phospholipids serum_ARA 0.00896 0.901 up up no no no no 18:0/18:0-PE+blood 13-HODE+blood -0.652631579 0 0 serum_phospholipids serum_ARA 0.00896 0.32 up up no no no no 18:0/18:0-PE+blood 16:0-LPC+blood 0 0 0.423589744 serum_phospholipids serum_phospholipids 0.00896 0.00456 up up no up up no 18:0/18:0-PE+blood 16:0-LPE+blood 0.493233083 0 0 serum_phospholipids serum_phospholipids 0.00896 0.0711 up up no up up no 18:0/18:0-PE+blood 16:0/14:0-PC+blood -0.479699248 0 -0.522735043 serum_phospholipids serum_phospholipids 0.00896 0.0206 up up no no up up 18:0/18:0-PE+blood 16:0/16:0-PI+blood 0.508270677 0.512254902 0 serum_phospholipids serum_phospholipids 0.00896 0.358 up up no no no no 18:0/18:0-PE+blood 16:0/16:1-PC+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.00896 0.00283 up up no up up no 18:0/18:0-PE+blood 16:0/16:1-PI+blood 0.45112782 0.490196078 0 serum_phospholipids serum_phospholipids 0.00896 0.262 up up no no no no 18:0/18:0-PE+blood 16:0/18:0-PS+blood 0.496240602 0 0 serum_phospholipids serum_phospholipids 0.00896 0.377 up up no no no no 18:0/18:0-PE+blood 16:0/18:1-PC+blood -0.613533835 0 0 serum_phospholipids serum_phospholipids 0.00896 6.15E-07 up up no up up up 18:0/18:0-PE+blood 16:0/18:1-PE+blood 0.763909774 0.526960784 0 serum_phospholipids serum_phospholipids 0.00896 0.000107 up up no up up no 18:0/18:0-PE+blood 16:0/18:2-PC+blood -0.678195489 0 -0.477606838 serum_phospholipids serum_phospholipids 0.00896 3.24E-06 up up no no up up 18:0/18:0-PE+blood 16:0/18:2-PI+blood 0.446616541 0.666666667 0 serum_phospholipids serum_phospholipids 0.00896 0.269 up up no no no no 18:0/18:0-PE+blood 16:0/20:3-PC+blood -0.598496241 0 0 serum_phospholipids serum_phospholipids 0.00896 5.43E-06 up up no no up up 18:0/18:0-PE+blood 16:0/20:4-PC+blood -0.470676692 -0.745098039 0 serum_phospholipids serum_phospholipids 0.00896 0.0262 up up no no up no 18:0/18:0-PE+blood 16:0/20:4-PE+blood 0.580451128 0 0 serum_phospholipids serum_phospholipids 0.00896 0.00139 up up no up up no 18:0/18:0-PE+blood 16:0/20:4-PI+blood 0.556390977 0 0 serum_phospholipids serum_phospholipids 0.00896 0.558 up up no no no no 18:0/18:0-PE+blood 16:0/22:6-PC+blood 0 -0.571078431 0 serum_phospholipids serum_phospholipids 0.00896 4.53E-05 up up no no up up 18:0/18:0-PE+blood 16:0/22:6-PE+blood 0.648120301 0 0 serum_phospholipids serum_phospholipids 0.00896 0.000934 up up no up up no 18:0/18:0-PE+blood 16:1/16:0-PC+blood -0.589473684 0 -0.566495726 serum_phospholipids serum_phospholipids 0.00896 0.0215 up up no no up up 18:0/18:0-PE+blood 16:1/16:1-PC+blood -0.482706767 0 -0.530940171 serum_phospholipids serum_phospholipids 0.00896 0.0177 up up no no no up 18:0/18:0-PE+blood 16:1/18:1-PG+blood -0.448120301 0 0 serum_phospholipids serum_phospholipids 0.00896 3.21E-05 up up no no up up 18:0/18:0-PE+blood 16:1/18:2-PG+blood -0.670676692 0 0 serum_phospholipids serum_phospholipids 0.00896 1.40E-08 up up no no up up 18:0/18:0-PE+blood 18:0-LPE+blood 0.615037594 0 0.420854701 serum_phospholipids serum_phospholipids 0.00896 0.491 up up no no no no 18:0/18:0-PE+blood 18:0/16:0-PC+blood -0.584962406 0 0 serum_phospholipids serum_phospholipids 0.00896 9.64E-07 up up no up up up 18:0/18:0-PS+blood 12-HEPE+blood -0.585380137 0 0 serum_phospholipids serum_ARA 0.00617 0.312 no up no no no no 18:0/18:0-PS+blood 12-ketoDCA+blood 0 -0.543374987 0 serum_phospholipids serum_bileacids 0.00617 0.517 no up no no no no 18:0/18:0-PS+blood 13-HODE+blood 0 -0.651960784 0 serum_phospholipids serum_ARA 0.00617 0.32 no up no no no no 18:0/18:0-PS+blood 15-HETE+blood -0.484862399 0 0 serum_phospholipids serum_ARA 0.00617 0.819 no up no no no no 18:0/18:0-PS+blood 16:0/14:0-PC+blood 0 0 -0.507008547 serum_phospholipids serum_phospholipids 0.00617 0.0206 no up no no up up 18:0/18:0-PS+blood 16:0/18:0-PS+blood 0.905263158 0.87254902 0.961025641 serum_phospholipids serum_phospholipids 0.00617 0.377 no up no no no no 18:0/18:0-PS+blood 16:0/18:1-PE+blood 0 0 0.558290598 serum_phospholipids serum_phospholipids 0.00617 0.000107 no up no up up no 18:0/18:0-PS+blood 16:0/20:4-PE+blood 0.603007519 0 0.570598291 serum_phospholipids serum_phospholipids 0.00617 0.00139 no up no up up no 18:0/18:0-PS+blood 16:0/20:5-PC+blood 0 0.524509804 0 serum_phospholipids serum_phospholipids 0.00617 0.628 no up no no no no 18:0/18:0-PS+blood 16:0/20:5-PG+blood 0 0 0.436581197 serum_phospholipids serum_phospholipids 0.00617 0.00656 no up no no up no 18:0/18:0-PS+blood 16:0/22:6-PE+blood 0.742857143 0.644607843 0.638290598 serum_phospholipids serum_phospholipids 0.00617 0.000934 no up no up up no 18:0/18:0-PS+blood 16:1/18:1-PG+blood 0 0 0.619145299 serum_phospholipids serum_phospholipids 0.00617 3.21E-05 no up no no up up 18:0/18:0-PS+blood 16:1/18:2-PG+blood 0 0 0.424273504 serum_phospholipids serum_phospholipids 0.00617 1.40E-08 no up no no up up 18:0/18:0-PS+blood 16:1+blood 0 0.49754902 0 yes serum_phospholipids serum_fattyacid 0.00617 0.0186 no up no no no dn 18:0/18:0-PS+blood 18:0-LPE+blood 0.494736842 0 0 serum_phospholipids serum_phospholipids 0.00617 0.491 no up no no no no 18:0/18:0-PS+blood 18:0/18:0-PC+blood 0 0.49754902 0 serum_phospholipids serum_phospholipids 0.00617 0.426 no up no no no no 18:0/18:0-PS+blood 18:0+blood 0 0.600490196 0 serum_phospholipids serum_fattyacid 0.00617 0.344 no up no no no no 18:0/18:0-PS+blood Acetic acid+stool 0 -0.645454545 0 yes serum_phospholipids stool_scfa 0.00617 0.0656 no up no dn no no 18:0/18:0-PS+blood Adipocytokine signaling pathway -0.566666667 -0.638235294 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Adrenergic signaling in cardiomyocytes -0.478947368 0 0 serum_phospholipids kegg 0.00617 NA no up no no no up 18:0/18:0-PS+blood Biosynthesis of amino acids 0.535087719 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood cAMP signaling pathway -0.501754386 -0.614705882 0 yes serum_phospholipids kegg 0.00617 NA no up no no up up 18:0/18:0-PS+blood Carbon metabolism 0.549122807 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Cellular senescence 0 0 0.436153846 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Chagas disease -0.48245614 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Chronic myeloid leukemia -0.492982456 -0.585294118 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Clostridium 0 0.533331721 0 serum_phospholipids Genus 0.00617 0.925 no up no no no no 18:0/18:0-PS+blood Collinsella 0.50602467 0 0 serum_phospholipids Genus 0.00617 0.128 no up no no no no 18:0/18:0-PS+blood Cytosolic DNA-sensing pathway 0 -0.638235294 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood DCA+stool 0 0 0.503759398 serum_phospholipids stool_bileacids 0.00617 0.195 no up no no no no 18:0/18:0-PS+blood Dopaminergic synapse -0.477192982 0 0 serum_phospholipids kegg 0.00617 NA no up no no up no 18:0/18:0-PS+blood Fc gamma R-mediated phagocytosis 0.494736842 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Glycolysis / Gluconeogenesis 0.561403509 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Hepatitis C 0 -0.602941176 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Human cytomegalovirus infection 0 0 0.416153846 serum_phospholipids kegg 0.00617 NA no up no no no dn 18:0/18:0-PS+blood Human papillomavirus infection 0 0 0.437692308 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Intestinal immune network for IgA production -0.529824561 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Kaposi sarcoma-associated herpesvirus infection -0.642105263 0 0 serum_phospholipids kegg 0.00617 NA no up no no no dn 18:0/18:0-PS+blood Long-term depression -0.457894737 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Longevity regulating pathway -0.498245614 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Longevity regulating pathway - multiple species 0.601754386 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Mitophagy - animal -0.487719298 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood mRNA surveillance pathway -0.48245614 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Necroptosis -0.456140351 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Neurotrophin signaling pathway 0 -0.567647059 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Parkinson disease -0.547368421 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Pathways of neurodegeneration - multiple diseases -0.540350877 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Peroxisome 0.475438596 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Primary immunodeficiency 0.543859649 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Propionic acid+stool 0 0 0.521804511 yes serum_phospholipids stool_scfa 0.00617 0.0436 no up no dn no up 18:0/18:0-PS+blood Prostate cancer 0 -0.591176471 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Relaxin signaling pathway -0.668421053 -0.502941176 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Shigellosis -0.540350877 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Th1 and Th2 cell differentiation -0.507017544 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Th17 cell differentiation -0.58245614 0 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood TNF signaling pathway -0.522807018 -0.511764706 0 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:0-PS+blood Viral carcinogenesis 0 0 0.445384615 serum_phospholipids kegg 0.00617 NA no up no no no no 18:0/18:1-PC+blood 14:0/18:0-PC+blood 0 0.558823529 0 serum_phospholipids serum_phospholipids 0.393 0.00289 no no no up up no 18:0/18:1-PC+blood 16:0/16:1-PC+blood 0 0.605392157 0 serum_phospholipids serum_phospholipids 0.393 0.00283 no no no up up no 18:0/18:1-PC+blood 16:0/16:1-PI+blood 0 0.634803922 0 serum_phospholipids serum_phospholipids 0.393 0.262 no no no no no no 18:0/18:1-PC+blood 16:0/18:0-PC+blood 0.547368421 0 0.505641026 serum_phospholipids serum_phospholipids 0.393 0.521 no no no no no no 18:0/18:1-PC+blood 16:0/18:1-PC+blood 0.44962406 0 0 serum_phospholipids serum_phospholipids 0.393 6.15E-07 no no no up up up 18:0/18:1-PC+blood 16:0/20:3-PC+blood 0 0.517156863 0 serum_phospholipids serum_phospholipids 0.393 5.43E-06 no no no no up up 18:0/18:1-PC+blood 16:1-LPC+blood -0.463157895 0 0 serum_phospholipids serum_phospholipids 0.393 0.0241 no no no no up no 18:0/18:1-PC+blood 18:0-LPC+blood 0 0 0.40034188 serum_phospholipids serum_phospholipids 0.393 0.554 no no no no no no 18:0/18:1-PC+blood 18:0/16:0-PC+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.393 9.64E-07 no no no up up up 18:0/18:1-PC+blood 18:0/18:0-PC+blood 0.972932331 0.990196078 0.993846154 serum_phospholipids serum_phospholipids 0.393 0.426 no no no no no no 18:0/18:1-PC+blood 18:0/18:0-PS+blood 0 0.522058824 0 serum_phospholipids serum_phospholipids 0.393 0.00617 no no no no up no 18:0/18:1-PC+blood Adherens junction 0 0.502941176 0 serum_phospholipids kegg 0.393 NA no no no no no no 18:0/18:1-PC+blood Arrhythmogenic right ventricular cardiomyopathy 0 0.541176471 0 serum_phospholipids kegg 0.393 NA no no no no up up 18:0/18:1-PC+blood Fusobacterium 0 -0.51244456 0 serum_phospholipids Genus 0.393 0.628 no no no no no no 18:0/18:1-PC+blood GCDCA+stool 0 0 0.44962406 yes serum_phospholipids stool_bileacids 0.393 0.0471 no no no no dn no 18:0/18:1-PC+blood GDCA+stool 0 0 0.600904296 serum_phospholipids stool_bileacids 0.393 0.656 no no no no no no 18:0/18:1-PC+blood "Growth hormone synthesis, secretion and action" 0 -0.573529412 0 serum_phospholipids kegg 0.393 NA no no no no no no 18:0/18:1-PC+blood Hippo signaling pathway 0 0.597058824 0 serum_phospholipids kegg 0.393 NA no no no no no no 18:0/18:1-PC+blood NOD-like receptor signaling pathway 0 -0.505882353 0 serum_phospholipids kegg 0.393 NA no no no no no no 18:0/18:1-PC+blood nutriCA+stool 0 0.789024032 0 serum_phospholipids stool_bileacids 0.393 0.481 no no no no no no 18:0/18:1-PC+blood Parabacteroides 0.490225564 0 0 serum_phospholipids Genus 0.393 4.19E-05 no no no no up up 18:0/18:1-PC+blood Propionic acid+stool 0 0 -0.47518797 yes serum_phospholipids stool_scfa 0.393 0.0436 no no no dn no up 18:0/18:1-PC+blood TCA+stool 0 0 0.487218045 serum_phospholipids stool_bileacids 0.393 0.458 no no no no no no 18:0/18:1-PC+blood Thyroid hormone signaling pathway 0 0.526470588 0 serum_phospholipids kegg 0.393 NA no no no no no no 18:0/18:1-PE+blood 12-ketoDCA+blood 0 -0.507149988 0 serum_phospholipids serum_bileacids 0.00716 0.517 up up no no no no 18:0/18:1-PE+blood 12-ketoDCA+stool 0 0 0.607518797 serum_phospholipids stool_bileacids 0.00716 0.505 up up no no no no 18:0/18:1-PE+blood "12,13-EPOME+blood" 0 0.589997689 0 serum_phospholipids serum_ARA 0.00716 0.901 up up no no no no 18:0/18:1-PE+blood 13-HODE+blood -0.652631579 0 0 serum_phospholipids serum_ARA 0.00716 0.32 up up no no no no 18:0/18:1-PE+blood 14:0/18:0-PC+blood 0 0.546568627 0 serum_phospholipids serum_phospholipids 0.00716 0.00289 up up no up up no 18:0/18:1-PE+blood 16:0-LPC+blood 0 0 0.503589744 serum_phospholipids serum_phospholipids 0.00716 0.00456 up up no up up no 18:0/18:1-PE+blood 16:0-LPE+blood 0.521804511 0 0 serum_phospholipids serum_phospholipids 0.00716 0.0711 up up no up up no 18:0/18:1-PE+blood 16:0/14:0-PC+blood -0.521804511 0 -0.565811966 serum_phospholipids serum_phospholipids 0.00716 0.0206 up up no no up up 18:0/18:1-PE+blood 16:0/16:0-PI+blood 0.538345865 0.639705882 0 serum_phospholipids serum_phospholipids 0.00716 0.358 up up no no no no 18:0/18:1-PE+blood 16:0/16:1-PC+blood 0 0.583333333 0 serum_phospholipids serum_phospholipids 0.00716 0.00283 up up no up up no 18:0/18:1-PE+blood 16:0/16:1-PI+blood 0.490225564 0.568627451 0 serum_phospholipids serum_phospholipids 0.00716 0.262 up up no no no no 18:0/18:1-PE+blood 16:0/18:0-PS+blood 0.488721805 0 0 serum_phospholipids serum_phospholipids 0.00716 0.377 up up no no no no 18:0/18:1-PE+blood 16:0/18:1-PC+blood -0.595488722 0 0 serum_phospholipids serum_phospholipids 0.00716 6.15E-07 up up no up up up 18:0/18:1-PE+blood 16:0/18:1-PE+blood 0.77593985 0.629901961 0.416752137 serum_phospholipids serum_phospholipids 0.00716 0.000107 up up no up up no 18:0/18:1-PE+blood 16:0/18:2-PC+blood -0.639097744 0 -0.455726496 serum_phospholipids serum_phospholipids 0.00716 3.24E-06 up up no no up up 18:0/18:1-PE+blood 16:0/18:2-PI+blood 0.482706767 0.757352941 0 serum_phospholipids serum_phospholipids 0.00716 0.269 up up no no no no 18:0/18:1-PE+blood 16:0/20:3-PC+blood -0.640601504 0 0 serum_phospholipids serum_phospholipids 0.00716 5.43E-06 up up no no up up 18:0/18:1-PE+blood 16:0/20:4-PC+blood -0.505263158 -0.774509804 0 serum_phospholipids serum_phospholipids 0.00716 0.0262 up up no no up no 18:0/18:1-PE+blood 16:0/20:4-PE+blood 0.593984962 0 0 serum_phospholipids serum_phospholipids 0.00716 0.00139 up up no up up no 18:0/18:1-PE+blood 16:0/20:4-PI+blood 0.547368421 0 0 serum_phospholipids serum_phospholipids 0.00716 0.558 up up no no no no 18:0/18:1-PE+blood 16:0/22:6-PC+blood 0 -0.602941176 0 serum_phospholipids serum_phospholipids 0.00716 4.53E-05 up up no no up up 18:0/18:1-PE+blood 16:0/22:6-PE+blood 0.637593985 0 0 serum_phospholipids serum_phospholipids 0.00716 0.000934 up up no up up no 18:0/18:1-PE+blood 16:1/16:0-PC+blood -0.6 0 -0.507008547 serum_phospholipids serum_phospholipids 0.00716 0.0215 up up no no up up 18:0/18:1-PE+blood 16:1/16:1-PC+blood -0.520300752 0 -0.503589744 serum_phospholipids serum_phospholipids 0.00716 0.0177 up up no no no up 18:0/18:1-PE+blood 16:1/18:1-PG+blood -0.473684211 0 0 serum_phospholipids serum_phospholipids 0.00716 3.21E-05 up up no no up up 18:0/18:1-PE+blood 16:1/18:2-PG+blood -0.685714286 0 0 serum_phospholipids serum_phospholipids 0.00716 1.40E-08 up up no no up up 18:0/18:1-PE+blood 18:0-LPE+blood 0.612030075 0 0.44957265 serum_phospholipids serum_phospholipids 0.00716 0.491 up up no no no no 18:0/18:1-PE+blood 18:0/16:0-PC+blood -0.565413534 0 0 serum_phospholipids serum_phospholipids 0.00716 9.64E-07 up up no up up up 18:0/18:1-PE+blood 18:0/18:0-PE+blood 0.977443609 0.948529412 0.927521368 serum_phospholipids serum_phospholipids 0.00716 0.00896 up up no up up no 18:0/18:1-PE+blood AGE-RAGE signaling pathway in diabetic complications 0 0 0.410769231 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Alcoholism -0.456140351 0 0 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Asthma -0.471929825 0 0 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Clostridium 0 0.581585543 0 serum_phospholipids Genus 0.00716 0.925 up up no no no no 18:0/18:1-PE+blood DCA+stool 0 0 0.49924812 serum_phospholipids stool_bileacids 0.00716 0.195 up up no no no no 18:0/18:1-PE+blood FoxO signaling pathway 0 -0.505882353 0 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Glioma 0 0 0.407692308 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Inflammatory bowel disease -0.570175439 0 0 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Inflammatory mediator regulation of TRP channels 0 0 0.480769231 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Intestinal immune network for IgA production -0.642105263 0 0 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood JAK-STAT signaling pathway 0 -0.5 0 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Lachnospira 0.503759398 0 0 butyrate-producing serum_phospholipids Genus 0.00716 0.279 up up no no no no 18:0/18:1-PE+blood LCA+stool 0 0 0.562406015 serum_phospholipids stool_bileacids 0.00716 0.314 up up no no no no 18:0/18:1-PE+blood MAPK signaling pathway 0 -0.514705882 0 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Melanogenesis 0 0 0.430769231 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Non-small cell lung cancer 0 -0.505882353 0 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Pancreatic cancer 0 0 0.472307692 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Prevotella 0.449779648 0 0 acetate-producing serum_phospholipids Genus 0.00716 0.287 up up no no no no 18:0/18:1-PE+blood Propionic acid+stool 0 0 0.503759398 yes serum_phospholipids stool_scfa 0.00716 0.0436 up up no dn no up 18:0/18:1-PE+blood Renin secretion 0 0 0.443846154 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Ruminococcus 0 0.550582568 0 serum_phospholipids Genus 0.00716 0.0679 up up no no no dn 18:0/18:1-PE+blood Small cell lung cancer 0 -0.529411765 0 serum_phospholipids kegg 0.00716 NA up up no no no up 18:0/18:1-PE+blood TCA+stool 0 0.7 0 serum_phospholipids stool_bileacids 0.00716 0.458 up up no no no no 18:0/18:1-PE+blood Tight junction 0 0.591176471 0 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Transcriptional misregulation in cancer 0 0 0.596153846 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PE+blood Vascular smooth muscle contraction 0 0.514705882 0 serum_phospholipids kegg 0.00716 NA up up no no no no 18:0/18:1-PG+blood 13-HODE+blood 0 -0.669117647 0 serum_phospholipids serum_ARA 0.000842 0.32 no up no no no no 18:0/18:1-PG+blood 14:0+blood 0 0.588235294 0 yes serum_phospholipids serum_fattyacid 0.000842 0.00572 no up no up no dn 18:0/18:1-PG+blood 14:1/18:2-PG+blood 0 0 0.486495726 serum_phospholipids serum_phospholipids 0.000842 0.00259 no up no no up up 18:0/18:1-PG+blood 15-HETE+blood -0.453043304 0 0 serum_phospholipids serum_ARA 0.000842 0.819 no up no no no no 18:0/18:1-PG+blood 16:0/14:0-PC+blood 0 0 -0.511794872 serum_phospholipids serum_phospholipids 0.000842 0.0206 no up no no up up 18:0/18:1-PG+blood 16:0/18:0-PC+blood 0 0 -0.403760684 serum_phospholipids serum_phospholipids 0.000842 0.521 no up no no no no 18:0/18:1-PG+blood 16:0/18:0-PS+blood 0 0 0.628717949 serum_phospholipids serum_phospholipids 0.000842 0.377 no up no no no no 18:0/18:1-PG+blood 16:0/18:1-PE+blood 0.681203008 0 0 serum_phospholipids serum_phospholipids 0.000842 0.000107 no up no up up no 18:0/18:1-PG+blood 16:0/18:2-PC+blood 0 0 -0.457777778 serum_phospholipids serum_phospholipids 0.000842 3.24E-06 no up no no up up 18:0/18:1-PG+blood 16:0/20:4-PE+blood 0.77593985 0 0.403760684 serum_phospholipids serum_phospholipids 0.000842 0.00139 no up no up up no 18:0/18:1-PG+blood 16:0/20:4-PI+blood 0 0 0.401709402 serum_phospholipids serum_phospholipids 0.000842 0.558 no up no no no no 18:0/18:1-PG+blood 16:0/20:5-PG+blood 0 0 0.429059829 serum_phospholipids serum_phospholipids 0.000842 0.00656 no up no no up no 18:0/18:1-PG+blood 16:0/22:0-PE+blood 0 0 -0.544615385 serum_phospholipids serum_phospholipids 0.000842 0.00839 no up no dn no up 18:0/18:1-PG+blood 16:0/22:6-PC+blood 0 0 -0.433162393 serum_phospholipids serum_phospholipids 0.000842 4.53E-05 no up no no up up 18:0/18:1-PG+blood 16:0/22:6-PE+blood 0.508270677 0 0 serum_phospholipids serum_phospholipids 0.000842 0.000934 no up no up up no 18:0/18:1-PG+blood 16:1/18:1-PG+blood 0 0 0.483760684 serum_phospholipids serum_phospholipids 0.000842 3.21E-05 no up no no up up 18:0/18:1-PG+blood 16:1+blood 0 0.529411765 0 yes serum_phospholipids serum_fattyacid 0.000842 0.0186 no up no no no dn 18:0/18:1-PG+blood 18:0-LPE+blood 0.6 0 0 serum_phospholipids serum_phospholipids 0.000842 0.491 no up no no no no 18:0/18:1-PG+blood 18:0/18:0-PC+blood 0 0 -0.461196581 serum_phospholipids serum_phospholipids 0.000842 0.426 no up no no no no 18:0/18:1-PG+blood 18:0/18:0-PE+blood 0.508270677 0 0 serum_phospholipids serum_phospholipids 0.000842 0.00896 no up no up up no 18:0/18:1-PG+blood 18:0/18:0-PS+blood 0 0.50245098 0.621196581 serum_phospholipids serum_phospholipids 0.000842 0.00617 no up no no up no 18:0/18:1-PG+blood 18:0/18:1-PC+blood 0 0 -0.470769231 serum_phospholipids serum_phospholipids 0.000842 0.393 no up no no no no 18:0/18:1-PG+blood 18:0/18:1-PE+blood 0.536842105 0 0 serum_phospholipids serum_phospholipids 0.000842 0.00716 no up no up up no 18:0/18:1-PI+blood 11-HETE+blood 0 0.579312842 0 serum_phospholipids serum_ARA 0.599 0.464 no no no no no no 18:0/18:1-PI+blood 12-ketoDCA+blood 0 -0.576306805 0 serum_phospholipids serum_bileacids 0.599 0.517 no no no no no no 18:0/18:1-PI+blood 14:0/18:0-PC+blood 0 0.553921569 0 serum_phospholipids serum_phospholipids 0.599 0.00289 no no no up up no 18:0/18:1-PI+blood 15-HETE+blood -0.586380463 0 -0.41870555 serum_phospholipids serum_ARA 0.599 0.819 no no no no no no 18:0/18:1-PI+blood 16:0-LPC+blood 0 0 0.401709402 serum_phospholipids serum_phospholipids 0.599 0.00456 no no no up up no 18:0/18:1-PI+blood 16:0/16:0-PI+blood 0 0.56372549 0 serum_phospholipids serum_phospholipids 0.599 0.358 no no no no no no 18:0/18:1-PI+blood 16:0/16:1-PC+blood 0 0.575980392 0 serum_phospholipids serum_phospholipids 0.599 0.00283 no no no up up no 18:0/18:1-PI+blood 16:0/16:1-PI+blood 0 0.68627451 0 serum_phospholipids serum_phospholipids 0.599 0.262 no no no no no no 18:0/18:1-PI+blood 16:0/18:0-PC+blood 0.494736842 0 0 serum_phospholipids serum_phospholipids 0.599 0.521 no no no no no no 18:0/18:1-PI+blood 16:0/18:1-PE+blood 0 0.544117647 0 serum_phospholipids serum_phospholipids 0.599 0.000107 no no no up up no 18:0/18:1-PI+blood 16:0/20:4-PC+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 0.599 0.0262 no no no no up no 18:0/18:1-PI+blood 16:0/22:6-PC+blood 0 -0.5 0 serum_phospholipids serum_phospholipids 0.599 4.53E-05 no no no no up up 18:0/18:1-PI+blood 16:1/16:0-PC+blood 0 0 -0.467350427 serum_phospholipids serum_phospholipids 0.599 0.0215 no no no no up up 18:0/18:1-PI+blood 16:1/16:1-PC+blood 0 0 -0.485811966 serum_phospholipids serum_phospholipids 0.599 0.0177 no no no no no up 18:0/18:1-PI+blood 16:1/18:1-PG+blood 0 0.708333333 0 serum_phospholipids serum_phospholipids 0.599 3.21E-05 no no no no up up 18:0/18:1-PI+blood 18:0-LPA+blood 0 0 0.411282051 serum_phospholipids serum_phospholipids 0.599 0.0725 no no no no dn no 18:0/18:1-PI+blood 18:0-LPC+blood 0.485714286 0 0 serum_phospholipids serum_phospholipids 0.599 0.554 no no no no no no 18:0/18:1-PI+blood 18:0-LPE+blood 0.45112782 0 0 serum_phospholipids serum_phospholipids 0.599 0.491 no no no no no no 18:0/18:1-PI+blood 18:0/18:0-PC+blood 0.535338346 0 0 serum_phospholipids serum_phospholipids 0.599 0.426 no no no no no no 18:0/18:1-PI+blood 18:0/18:0-PE+blood 0 0.583333333 0 serum_phospholipids serum_phospholipids 0.599 0.00896 no no no up up no 18:0/18:1-PI+blood 18:0/18:1-PC+blood 0.551879699 0 0 serum_phospholipids serum_phospholipids 0.599 0.393 no no no no no no 18:0/18:1-PI+blood 18:0/18:1-PE+blood 0 0.541666667 0 serum_phospholipids serum_phospholipids 0.599 0.00716 no no no up up no 18:0/18:1-PI+blood 18:0/18:1-PG+blood 0.551879699 0 0 serum_phospholipids serum_phospholipids 0.599 0.000842 no no no no up no 18:0/18:2-PC+blood 16:0-LPE+blood -0.505263158 0 0 serum_phospholipids serum_phospholipids 1.74E-06 0.0711 no up up up up no 18:0/18:2-PC+blood 16:0/14:0-PC+blood 0.610526316 0.862745098 0.820854701 serum_phospholipids serum_phospholipids 1.74E-06 0.0206 no up up no up up 18:0/18:2-PC+blood 16:0/16:0-PC+blood 0.639097744 0.588235294 0.67042735 serum_phospholipids serum_phospholipids 1.74E-06 0.00079 no up up no up up 18:0/18:2-PC+blood 16:0/16:0-PI+blood -0.54887218 0 0 serum_phospholipids serum_phospholipids 1.74E-06 0.358 no up up no no no 18:0/18:2-PC+blood 16:0/16:1-PI+blood -0.672180451 0 0 serum_phospholipids serum_phospholipids 1.74E-06 0.262 no up up no no no 18:0/18:2-PC+blood 16:0/18:0-PC+blood 0 0 0.546666667 serum_phospholipids serum_phospholipids 1.74E-06 0.521 no up up no no no 18:0/18:2-PC+blood 16:0/18:0-PS+blood 0 0 -0.477606838 serum_phospholipids serum_phospholipids 1.74E-06 0.377 no up up no no no 18:0/18:2-PC+blood 16:0/18:1-PC+blood 0.8 0.825980392 0.598632479 serum_phospholipids serum_phospholipids 1.74E-06 6.15E-07 no up up up up up 18:0/18:2-PC+blood 16:0/18:1-PE+blood -0.587969925 0 0 serum_phospholipids serum_phospholipids 1.74E-06 0.000107 no up up up up no 18:0/18:2-PC+blood 16:0/18:2-PC+blood 0.896240602 0.796568627 0.831111111 serum_phospholipids serum_phospholipids 1.74E-06 3.24E-06 no up up no up up 18:0/18:2-PC+blood 16:0/20:3-PC+blood 0.77593985 0.691176471 0.493333333 serum_phospholipids serum_phospholipids 1.74E-06 5.43E-06 no up up no up up 18:0/18:2-PC+blood 16:0/20:4-PC+blood 0.539849624 0 0.574700855 serum_phospholipids serum_phospholipids 1.74E-06 0.0262 no up up no up no 18:0/18:2-PC+blood 16:0/20:4-PI+blood -0.610526316 -0.490196078 0 serum_phospholipids serum_phospholipids 1.74E-06 0.558 no up up no no no 18:0/18:2-PC+blood 16:0/22:0-PE+blood 0 0 0.475555556 serum_phospholipids serum_phospholipids 1.74E-06 0.00839 no up up dn no up 18:0/18:2-PC+blood 16:0/22:6-PC+blood 0.652631579 0 0.752478632 serum_phospholipids serum_phospholipids 1.74E-06 4.53E-05 no up up no up up 18:0/18:2-PC+blood 16:1-LPC+blood 0 -0.546568627 0 serum_phospholipids serum_phospholipids 1.74E-06 0.0241 no up up no up no 18:0/18:2-PC+blood 16:1/16:0-PC+blood 0.787969925 0 0.697777778 serum_phospholipids serum_phospholipids 1.74E-06 0.0215 no up up no up up 18:0/18:2-PC+blood 16:1/16:1-PC+blood 0.639097744 0 0.522735043 serum_phospholipids serum_phospholipids 1.74E-06 0.0177 no up up no no up 18:0/18:2-PC+blood 16:1/18:2-PG+blood 0.627067669 0 0 serum_phospholipids serum_phospholipids 1.74E-06 1.40E-08 no up up no up up 18:0/18:2-PC+blood 18:0-LPC+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 1.74E-06 0.554 no up up no no no 18:0/18:2-PC+blood 18:0-LPE+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 1.74E-06 0.491 no up up no no no 18:0/18:2-PC+blood 18:0/16:0-PC+blood 0.751879699 0.767156863 0.571965812 serum_phospholipids serum_phospholipids 1.74E-06 9.64E-07 no up up up up up 18:0/18:2-PC+blood 18:0/18:0-PE+blood -0.577443609 0 0 serum_phospholipids serum_phospholipids 1.74E-06 0.00896 no up up up up no 18:0/18:2-PC+blood 18:0/18:0-PS+blood 0 0 -0.459145299 serum_phospholipids serum_phospholipids 1.74E-06 0.00617 no up up no up no 18:0/18:2-PC+blood 18:0/18:1-PE+blood -0.57593985 0 -0.422905983 serum_phospholipids serum_phospholipids 1.74E-06 0.00716 no up up up up no 18:0/18:2-PC+blood 18:0/18:1-PG+blood 0 0 -0.6 serum_phospholipids serum_phospholipids 1.74E-06 0.000842 no up up no up no 18:0/18:2-PC+blood 18:0+blood 0 0 0.509059829 serum_phospholipids serum_fattyacid 1.74E-06 0.344 no up up no no no 18:0/18:2-PC+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.487218045 serum_phospholipids stool_cometabolism 1.74E-06 0.33 no up up no no no 18:0/18:2-PC+blood Adherens junction 0 0 -0.411538462 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood Alzheimer disease 0 0 -0.501538462 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood Amoebiasis 0.478947368 0 0 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood Amyotrophic lateral sclerosis 0 0 -0.51 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.422307692 serum_phospholipids kegg 1.74E-06 NA no up up no up up 18:0/18:2-PC+blood Butyricicoccus 0 0 -0.41794711 butyrate-producing serum_phospholipids Genus 1.74E-06 0.852 no up up no no no 18:0/18:2-PC+blood Cardiac muscle contraction 0 0 -0.565384615 serum_phospholipids kegg 1.74E-06 NA no up up no no up 18:0/18:2-PC+blood Central carbon metabolism in cancer 0 -0.541176471 0 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood DCA+stool 0 0 -0.509774436 serum_phospholipids stool_bileacids 1.74E-06 0.195 no up up no no no 18:0/18:2-PC+blood Diabetic cardiomyopathy 0 0 -0.506923077 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood Dilated cardiomyopathy 0 0 -0.413846154 serum_phospholipids kegg 1.74E-06 NA no up up no up up 18:0/18:2-PC+blood Focal adhesion 0 0 -0.446153846 serum_phospholipids kegg 1.74E-06 NA no up up no up up 18:0/18:2-PC+blood Fusobacterium 0 -0.647778583 0 serum_phospholipids Genus 1.74E-06 0.628 no up up no no no 18:0/18:2-PC+blood GCDCA+stool 0 0.609090909 0 yes serum_phospholipids stool_bileacids 1.74E-06 0.0471 no up up no dn no 18:0/18:2-PC+blood Hepatocellular carcinoma 0 0 -0.409230769 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood Hippo signaling pathway 0 0 -0.468461538 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood Huntington disease 0 0 -0.46 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood Hypertrophic cardiomyopathy 0 0 -0.414615385 serum_phospholipids kegg 1.74E-06 NA no up up no up up 18:0/18:2-PC+blood Intestinal immune network for IgA production 0.503508772 0 0 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood L-Phenylalanine+stool 0 0 0.467669173 serum_phospholipids stool_cometabolism 1.74E-06 0.398 no up up no no no 18:0/18:2-PC+blood L-Tyrosine+stool 0 0 0.476691729 serum_phospholipids stool_cometabolism 1.74E-06 0.44 no up up no no no 18:0/18:2-PC+blood Lachnospira 0 0 0.445206132 butyrate-producing serum_phospholipids Genus 1.74E-06 0.279 no up up no no no 18:0/18:2-PC+blood mTOR signaling pathway 0 0 0.486153846 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood Non-alcoholic fatty liver disease 0 0 -0.456923077 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood Oxidative phosphorylation 0 0 -0.480769231 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood Phenylacetic acid+stool 0 -0.763636364 0 serum_phospholipids stool_cometabolism 1.74E-06 0.785 no up up no no no 18:0/18:2-PC+blood PI3K-Akt signaling pathway -0.484210526 0 0 yes serum_phospholipids kegg 1.74E-06 NA no up up no up up 18:0/18:2-PC+blood Prion disease 0 0 -0.56 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood Propionic acid+stool 0 0 -0.461654135 yes serum_phospholipids stool_scfa 1.74E-06 0.0436 no up up dn no up 18:0/18:2-PC+blood Retrograde endocannabinoid signaling 0 0 -0.414615385 serum_phospholipids kegg 1.74E-06 NA no up up no no up 18:0/18:2-PC+blood Salivary secretion 0.550877193 0 0 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PC+blood Thyroid hormone signaling pathway 0 0 -0.536923077 serum_phospholipids kegg 1.74E-06 NA no up up no no no 18:0/18:2-PI+blood 14:0-LPC+blood 0 0 0.424273504 serum_phospholipids serum_phospholipids 0.179 0.00689 no no no up up no 18:0/18:2-PI+blood 14:1/18:2-PG+blood 0 0 0.463247863 serum_phospholipids serum_phospholipids 0.179 0.00259 no no no no up up 18:0/18:2-PI+blood 16:0-LPC+blood 0 0 0.487179487 serum_phospholipids serum_phospholipids 0.179 0.00456 no no no up up no 18:0/18:2-PI+blood 16:0/16:0-PI+blood 0 0 0.486495726 serum_phospholipids serum_phospholipids 0.179 0.358 no no no no no no 18:0/18:2-PI+blood 16:0/16:1-PI+blood 0 0 0.412649573 serum_phospholipids serum_phospholipids 0.179 0.262 no no no no no no 18:0/18:2-PI+blood 16:0/18:2-PI+blood 0.481203008 0 0.53025641 serum_phospholipids serum_phospholipids 0.179 0.269 no no no no no no 18:0/18:2-PI+blood 16:0/20:4-PI+blood 0 0 0.505641026 serum_phospholipids serum_phospholipids 0.179 0.558 no no no no no no 18:0/18:2-PI+blood 16:0/20:5-PC+blood -0.496240602 0 0 serum_phospholipids serum_phospholipids 0.179 0.628 no no no no no no 18:0/18:2-PI+blood 16:1-LPC+blood 0 0 0.450940171 serum_phospholipids serum_phospholipids 0.179 0.0241 no no no no up no 18:0/18:2-PI+blood 16:1/18:2-PG+blood 0 0.651960784 0.446153846 serum_phospholipids serum_phospholipids 0.179 1.40E-08 no no no no up up 18:0/18:2-PI+blood 18:0-LPC+blood 0 0 0.45982906 serum_phospholipids serum_phospholipids 0.179 0.554 no no no no no no 18:0/18:2-PI+blood 18:0/18:1-PI+blood 0 0 0.697777778 serum_phospholipids serum_phospholipids 0.179 0.599 no no no no no no 18:0/18:2-PI+blood 4-hydroxybenzoic acid+stool 0.813186813 0 0 serum_phospholipids stool_cometabolism 0.179 0.0536 no no no no dn no 18:0/18:2-PI+blood ACA+stool -0.570087713 0 0 serum_phospholipids stool_bileacids 0.179 0.417 no no no no no no 18:0/18:2-PI+blood Adipocytokine signaling pathway -0.510526316 0 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Akkermansia 0 0 -0.43528575 acetate-producing serum_phospholipids Genus 0.179 0.23 no no no no no no 18:0/18:2-PI+blood Antigen processing and presentation 0 0 -0.417692308 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Apoptosis 0 0.511764706 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Biosynthesis of amino acids 0 0 -0.407692308 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Biosynthesis of cofactors 0 -0.552941176 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood C-type lectin receptor signaling pathway 0 0 0.401538462 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Calcium signaling pathway 0 0 0.503076923 serum_phospholipids kegg 0.179 NA no no no no up up 18:0/18:2-PI+blood Carbon metabolism 0 0 -0.574615385 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Chemokine signaling pathway 0 0.529411765 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Chronic myeloid leukemia 0 0 0.490769231 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Complement and coagulation cascades 0 0 -0.45 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Cushing syndrome 0 0 0.461538462 serum_phospholipids kegg 0.179 NA no no no no no up 18:0/18:2-PI+blood Epithelial cell signaling in Helicobacter pylori infection 0 0.514705882 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Fc gamma R-mediated phagocytosis 0 0 -0.510769231 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Glutamatergic synapse -0.547368421 0 0 serum_phospholipids kegg 0.179 NA no no no no up up 18:0/18:2-PI+blood Glycolysis / Gluconeogenesis 0 0 -0.537692308 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood GnRH signaling pathway -0.468421053 0 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Hepatitis B 0 0 0.585384615 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Hepatitis C 0 0 0.533076923 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Insulin resistance 0 0 0.672307692 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Kaposi sarcoma-associated herpesvirus infection -0.612280702 0.523529412 0 serum_phospholipids kegg 0.179 NA no no no no no dn 18:0/18:2-PI+blood Long-term depression -0.577192982 0.514705882 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Long-term potentiation 0 -0.579411765 0 serum_phospholipids kegg 0.179 NA no no no no no up 18:0/18:2-PI+blood Longevity regulating pathway -0.498245614 0 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Longevity regulating pathway - multiple species 0.471929825 0 -0.508461538 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Morphine addiction -0.564912281 0 0 serum_phospholipids kegg 0.179 NA no no no no up up 18:0/18:2-PI+blood Neurotrophin signaling pathway 0 0 0.500769231 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood NF-kappa B signaling pathway 0 0 0.492307692 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Oxytocin signaling pathway 0 0 -0.488461538 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Pathways in cancer 0 0 0.460769231 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 0.533076923 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Pertussis 0 0 -0.402307692 serum_phospholipids kegg 0.179 NA no no no no no dn 18:0/18:2-PI+blood Phosphatidylinositol signaling system 0 -0.635294118 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Primary immunodeficiency 0.626315789 0 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Prostate cancer 0 0 0.624615385 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Regulation of actin cytoskeleton 0 0 -0.454615385 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Relaxin signaling pathway -0.528070175 0 0.418461538 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Rheumatoid arthritis 0 0 -0.445384615 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood RIG-I-like receptor signaling pathway 0 0 0.583846154 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Ruminococcus 0 0 0.428494654 serum_phospholipids Genus 0.179 0.0679 no no no no no dn 18:0/18:2-PI+blood Salmonella infection 0.577192982 0 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Small cell lung cancer 0 0 0.538461538 serum_phospholipids kegg 0.179 NA no no no no no up 18:0/18:2-PI+blood Staphylococcus aureus infection 0 0 -0.475384615 serum_phospholipids kegg 0.179 NA no no no up no no 18:0/18:2-PI+blood Tight junction 0 0 -0.531538462 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood TNF signaling pathway 0 0 0.408461538 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Transcriptional misregulation in cancer 0 0 0.491538462 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/18:2-PI+blood Tuberculosis 0 0 -0.513076923 serum_phospholipids kegg 0.179 NA no no no no no dn 18:0/18:2-PI+blood Yersinia infection 0 0.547058824 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:0/20:2-PC+blood 13-HODE+blood -0.446616541 0 0 serum_phospholipids serum_ARA 0.733 0.32 no no no no no no 18:0/20:2-PC+blood 14:0/18:0-PC+blood 0 0.544117647 0 serum_phospholipids serum_phospholipids 0.733 0.00289 no no no up up no 18:0/20:2-PC+blood 16:0/16:1-PC+blood 0 0.531862745 0 serum_phospholipids serum_phospholipids 0.733 0.00283 no no no up up no 18:0/20:2-PC+blood 16:0/16:1-PI+blood 0 0.568627451 0 serum_phospholipids serum_phospholipids 0.733 0.262 no no no no no no 18:0/20:2-PC+blood 16:0/18:0-PC+blood 0 0 0.61982906 serum_phospholipids serum_phospholipids 0.733 0.521 no no no no no no 18:0/20:2-PC+blood 16:0/18:0-PS+blood 0 0 -0.464615385 serum_phospholipids serum_phospholipids 0.733 0.377 no no no no no no 18:0/20:2-PC+blood 16:0/18:1-PE+blood 0 0 -0.517264957 serum_phospholipids serum_phospholipids 0.733 0.000107 no no no up up no 18:0/20:2-PC+blood 16:0/20:3-PC+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 0.733 5.43E-06 no no no no up up 18:0/20:2-PC+blood 16:0/20:4-PE+blood 0 0 -0.581538462 serum_phospholipids serum_phospholipids 0.733 0.00139 no no no up up no 18:0/20:2-PC+blood 16:0/22:0-PE+blood 0 0 0.424273504 serum_phospholipids serum_phospholipids 0.733 0.00839 no no no dn no up 18:0/20:2-PC+blood 16:0/22:6-PE+blood 0 0 -0.588376068 serum_phospholipids serum_phospholipids 0.733 0.000934 no no no up up no 18:0/20:2-PC+blood 18:0-LPC+blood 0 0 0.515213675 serum_phospholipids serum_phospholipids 0.733 0.554 no no no no no no 18:0/20:2-PC+blood 18:0/18:0-PC+blood 0.762406015 0.769607843 0.794871795 serum_phospholipids serum_phospholipids 0.733 0.426 no no no no no no 18:0/20:2-PC+blood 18:0/18:0-PE+blood 0.455639098 0 0 serum_phospholipids serum_phospholipids 0.733 0.00896 no no no up up no 18:0/20:2-PC+blood 18:0/18:0-PS+blood 0 0 -0.533675214 serum_phospholipids serum_phospholipids 0.733 0.00617 no no no no up no 18:0/20:2-PC+blood 18:0/18:1-PC+blood 0.744360902 0.75 0.79008547 serum_phospholipids serum_phospholipids 0.733 0.393 no no no no no no 18:0/20:2-PC+blood 18:0/18:1-PG+blood 0 0 -0.541880342 serum_phospholipids serum_phospholipids 0.733 0.000842 no no no no up no 18:0/20:2-PC+blood Axon guidance 0 0.535294118 0 serum_phospholipids kegg 0.733 NA no no no no up up 18:0/20:2-PC+blood Butyricicoccus 0.481701789 0 0 butyrate-producing serum_phospholipids Genus 0.733 0.852 no no no no no no 18:0/20:2-PC+blood Clostridium 0.46099336 0 -0.432196147 serum_phospholipids Genus 0.733 0.925 no no no no no no 18:0/20:2-PC+blood nutriCA+stool 0 0.706451749 0 serum_phospholipids stool_bileacids 0.733 0.481 no no no no no no 18:0/20:2-PC+blood Paraprevotella 0 0 0.46752173 serum_phospholipids Genus 0.733 0.118 no no no no no no 18:0/20:2-PC+blood Ruminococcus 0 0.593137255 0 acetate-producing serum_phospholipids Genus 0.733 0.335 no no no no no no 18:0/20:3-PC+blood "12,13-EPOME+blood" 0 0 -0.458528948 serum_phospholipids serum_ARA 0.0682 0.901 no up no no no no 18:0/20:3-PC+blood 14:0/16:0-PC+blood 0 0.490196078 0.416752137 serum_phospholipids serum_phospholipids 0.0682 0.0358 no up no no up no 18:0/20:3-PC+blood 14:0/18:0-PC+blood 0 0.720588235 0 serum_phospholipids serum_phospholipids 0.0682 0.00289 no up no up up no 18:0/20:3-PC+blood 14:0/18:2-PC+blood 0.631578947 0 0 serum_phospholipids serum_phospholipids 0.0682 0.102 no up no no up no 18:0/20:3-PC+blood 14:0/20:4-PC+blood 0.643609023 0 0 serum_phospholipids serum_phospholipids 0.0682 0.486 no up no no no no 18:0/20:3-PC+blood 16:0/16:0-PI+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 0.0682 0.358 no up no no no no 18:0/20:3-PC+blood 16:0/16:1-PC+blood 0 0.740196078 0 serum_phospholipids serum_phospholipids 0.0682 0.00283 no up no up up no 18:0/20:3-PC+blood 16:0/16:1-PI+blood 0 0.784313725 0 serum_phospholipids serum_phospholipids 0.0682 0.262 no up no no no no 18:0/20:3-PC+blood 16:0/18:2-PI+blood 0 0.512254902 0 serum_phospholipids serum_phospholipids 0.0682 0.269 no up no no no no 18:0/20:3-PC+blood 16:0/20:3-PC+blood 0 0.590686275 0.739487179 serum_phospholipids serum_phospholipids 0.0682 5.43E-06 no up no no up up 18:0/20:3-PC+blood 16:0/20:4-PI+blood 0 0.524509804 0 serum_phospholipids serum_phospholipids 0.0682 0.558 no up no no no no 18:0/20:3-PC+blood 18:0-LPC+blood 0.452631579 0 0 serum_phospholipids serum_phospholipids 0.0682 0.554 no up no no no no 18:0/20:3-PC+blood 18:0/18:0-PC+blood 0 0.850490196 0.534358974 serum_phospholipids serum_phospholipids 0.0682 0.426 no up no no no no 18:0/20:3-PC+blood 18:0/18:1-PC+blood 0 0.855392157 0.516581197 serum_phospholipids serum_phospholipids 0.0682 0.393 no up no no no no 18:0/20:3-PC+blood 18:0/18:1-PI+blood 0 0.546568627 0 serum_phospholipids serum_phospholipids 0.0682 0.599 no up no no no no 18:0/20:3-PC+blood 18:0/20:2-PC+blood 0.512781955 0.840686275 0.488547009 serum_phospholipids serum_phospholipids 0.0682 0.733 no up no no no no 18:0/20:3-PC+blood 18:0+blood 0.592481203 0 0 serum_phospholipids serum_fattyacid 0.0682 0.344 no up no no no no 18:0/20:3-PC+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0.604395604 0 0 serum_phospholipids stool_cometabolism 0.0682 0.33 no up no no no no 18:0/20:3-PC+blood Adipocytokine signaling pathway 0 0 0.55 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood AMPK signaling pathway 0 0 0.403076923 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Arachidonic acid metabolism 0 0 0.404615385 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Biosynthesis of cofactors 0 0 0.425384615 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Central carbon metabolism in cancer 0 0 -0.461538462 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Clostridium 0.523505114 0.568976195 0 serum_phospholipids Genus 0.0682 0.925 no up no no no no 18:0/20:3-PC+blood Ferroptosis 0 0 0.535384615 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood FoxO signaling pathway 0 0 -0.63 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Glioma 0 0 -0.402307692 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Glutathione metabolism 0 0 0.503846154 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood "Glycine, serine and threonine metabolism" 0 0 0.462307692 serum_phospholipids kegg 0.0682 NA no up no no up no 18:0/20:3-PC+blood HDCA+stool 0 0 -0.49924812 serum_phospholipids stool_bileacids 0.0682 0.176 no up no no no no 18:0/20:3-PC+blood Kaposi sarcoma-associated herpesvirus infection 0 0 0.598461538 serum_phospholipids kegg 0.0682 NA no up no no no dn 18:0/20:3-PC+blood Longevity regulating pathway 0 0 0.437692308 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Mineral absorption 0 0 0.464615385 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Mitophagy - animal 0 0 0.409230769 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Necroptosis 0 0 0.405384615 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood NOD-like receptor signaling pathway 0 -0.523529412 0 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood nutriCA+stool 0 0.84407222 0 serum_phospholipids stool_bileacids 0.0682 0.481 no up no no no no 18:0/20:3-PC+blood Oocyte meiosis 0 0 -0.473846154 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Pathways of neurodegeneration - multiple diseases 0 0 0.42 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Phosphatidylinositol signaling system 0 0 -0.451538462 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Platinum drug resistance 0 0 -0.455384615 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Porphyrin and chlorophyll metabolism 0 0 0.488461538 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Primary immunodeficiency 0 0 -0.492307692 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Progesterone-mediated oocyte maturation 0 0 -0.488461538 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Purine metabolism 0 0 0.43 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Ruminococcus 0 0.629901961 0 acetate-producing serum_phospholipids Genus 0.0682 0.335 no up no no no no 18:0/20:3-PC+blood Shigellosis 0 0 0.446923077 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Sphingolipid signaling pathway 0 0 -0.486153846 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Spinocerebellar ataxia 0 0 -0.449230769 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PC+blood Thyroid hormone synthesis 0 0 0.457692308 serum_phospholipids kegg 0.0682 NA no up no no no no 18:0/20:3-PI+blood 11-HETE+blood 0 0.553501874 0 serum_phospholipids serum_ARA 0.377 0.464 no no no no no no 18:0/20:3-PI+blood 12-ketoDCA+blood 0 -0.582893168 0 serum_phospholipids serum_bileacids 0.377 0.517 no no no no no no 18:0/20:3-PI+blood 13-HODE+blood 0.618045113 0 0 serum_phospholipids serum_ARA 0.377 0.32 no no no no no no 18:0/20:3-PI+blood 14:0-LPC+blood 0 0 0.463247863 serum_phospholipids serum_phospholipids 0.377 0.00689 no no no up up no 18:0/20:3-PI+blood 14:0/16:0-PC+blood 0 0.534313725 0 serum_phospholipids serum_phospholipids 0.377 0.0358 no no no no up no 18:0/20:3-PI+blood 14:0/18:0-PC+blood 0 0.625 0 serum_phospholipids serum_phospholipids 0.377 0.00289 no no no up up no 18:0/20:3-PI+blood 14:0+blood 0 0 0.405128205 yes serum_phospholipids serum_fattyacid 0.377 0.00572 no no no up no dn 18:0/20:3-PI+blood 14:1/18:2-PG+blood 0 0 0.555555556 serum_phospholipids serum_phospholipids 0.377 0.00259 no no no no up up 18:0/20:3-PI+blood 16:0-LPC+blood 0.491729323 0 0 serum_phospholipids serum_phospholipids 0.377 0.00456 no no no up up no 18:0/20:3-PI+blood 16:0/16:1-PC+blood 0 0.629901961 0 serum_phospholipids serum_phospholipids 0.377 0.00283 no no no up up no 18:0/20:3-PI+blood 16:0/16:1-PI+blood 0 0.571078431 0 serum_phospholipids serum_phospholipids 0.377 0.262 no no no no no no 18:0/20:3-PI+blood 16:0/18:1-PE+blood 0 0.625 0 serum_phospholipids serum_phospholipids 0.377 0.000107 no no no up up no 18:0/20:3-PI+blood 16:0/18:3-PC+blood 0 -0.522058824 0 serum_phospholipids serum_phospholipids 0.377 0.00216 no no no no up up 18:0/20:3-PI+blood 16:0/20:3-PC+blood 0 0.678921569 0 serum_phospholipids serum_phospholipids 0.377 5.43E-06 no no no no up up 18:0/20:3-PI+blood 16:0/20:4-PE+blood 0 0.534313725 0 serum_phospholipids serum_phospholipids 0.377 0.00139 no no no up up no 18:0/20:3-PI+blood 16:0/20:5-PC+blood -0.589473684 0 0 serum_phospholipids serum_phospholipids 0.377 0.628 no no no no no no 18:0/20:3-PI+blood 16:1/18:1-PG+blood 0.505263158 0.723039216 0 serum_phospholipids serum_phospholipids 0.377 3.21E-05 no no no no up up 18:0/20:3-PI+blood 16:1/18:2-PG+blood 0.529323308 0 0 serum_phospholipids serum_phospholipids 0.377 1.40E-08 no no no no up up 18:0/20:3-PI+blood 16:1+blood 0.466165414 0.487745098 0 yes serum_phospholipids serum_fattyacid 0.377 0.0186 no no no no no dn 18:0/20:3-PI+blood 18:0/18:1-PI+blood 0 0.693627451 0 serum_phospholipids serum_phospholipids 0.377 0.599 no no no no no no 18:0/20:3-PI+blood 18:0/20:3-PC+blood 0 0.625 0 serum_phospholipids serum_phospholipids 0.377 0.0682 no no no no up no 18:0/20:3-PI+blood Amoebiasis 0 0 -0.412307692 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:3-PI+blood Antigen processing and presentation 0 0.611764706 0 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:3-PI+blood CDCA+stool 0 0.709090909 0 serum_phospholipids stool_bileacids 0.377 0.663 no no no no no no 18:0/20:3-PI+blood Clostridium 0 0.597179757 0 serum_phospholipids Genus 0.377 0.925 no no no no no no 18:0/20:3-PI+blood Coronavirus disease - COVID-19 0 0 0.471538462 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:3-PI+blood Epstein-Barr virus infection 0 0.676470588 0 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:3-PI+blood GnRH signaling pathway 0 -0.605882353 0 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:3-PI+blood Herpes simplex virus 1 infection 0 0.617647059 0 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:3-PI+blood Human cytomegalovirus infection 0 0.608823529 0 serum_phospholipids kegg 0.377 NA no no no no no dn 18:0/20:3-PI+blood Human immunodeficiency virus 1 infection 0 0.65 0 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:3-PI+blood Human T-cell leukemia virus 1 infection 0 0.614705882 0 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:3-PI+blood MAPK signaling pathway 0 -0.517647059 0 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:3-PI+blood Mitophagy - animal 0 0 0.406923077 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:3-PI+blood nutriCA+stool 0 0.697277051 0 serum_phospholipids stool_bileacids 0.377 0.481 no no no no no no 18:0/20:3-PI+blood Pathways of neurodegeneration - multiple diseases 0 0 0.408461538 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:3-PI+blood Ribosome 0 0 0.471538462 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:3-PI+blood Sphingolipid signaling pathway 0 0.5 0 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:3-PI+blood TCA+stool 0 0.627272727 0 serum_phospholipids stool_bileacids 0.377 0.458 no no no no no no 18:0/20:3-PI+blood Ubiquitin mediated proteolysis 0 0 0.408461538 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:3-PI+blood UDCA+stool 0 0.709090909 0 serum_phospholipids stool_bileacids 0.377 0.266 no no no no no no 18:0/20:3-PI+blood Viral myocarditis 0 0.547058824 0 serum_phospholipids kegg 0.377 NA no no no no no no 18:0/20:4-PC+blood 14:0-LPC+blood 0 -0.482843137 0 serum_phospholipids serum_phospholipids 0.454 0.00689 no no no up up no 18:0/20:4-PC+blood 14:0/18:0-PC+blood 0 -0.683823529 0 serum_phospholipids serum_phospholipids 0.454 0.00289 no no no up up no 18:0/20:4-PC+blood 16:0-LPC+blood 0 0 -0.580854701 serum_phospholipids serum_phospholipids 0.454 0.00456 no no no up up no 18:0/20:4-PC+blood 16:0-LPE+blood -0.512781955 0 0 serum_phospholipids serum_phospholipids 0.454 0.0711 no no no up up no 18:0/20:4-PC+blood 16:0/14:0-PC+blood 0.603007519 0 0.561709402 serum_phospholipids serum_phospholipids 0.454 0.0206 no no no no up up 18:0/20:4-PC+blood 16:0/16:0-PC+blood 0.490225564 0 0.446153846 serum_phospholipids serum_phospholipids 0.454 0.00079 no no no no up up 18:0/20:4-PC+blood 16:0/16:0-PI+blood -0.589473684 -0.723039216 0 serum_phospholipids serum_phospholipids 0.454 0.358 no no no no no no 18:0/20:4-PC+blood 16:0/16:1-PC+blood 0 -0.681372549 0 serum_phospholipids serum_phospholipids 0.454 0.00283 no no no up up no 18:0/20:4-PC+blood 16:0/16:1-PI+blood -0.676691729 -0.610294118 0 serum_phospholipids serum_phospholipids 0.454 0.262 no no no no no no 18:0/20:4-PC+blood 16:0/18:1-PC+blood 0.721804511 0 0 serum_phospholipids serum_phospholipids 0.454 6.15E-07 no no no up up up 18:0/20:4-PC+blood 16:0/18:1-PE+blood -0.616541353 -0.676470588 0 serum_phospholipids serum_phospholipids 0.454 0.000107 no no no up up no 18:0/20:4-PC+blood 16:0/18:2-PC+blood 0.581954887 0 0.470769231 serum_phospholipids serum_phospholipids 0.454 3.24E-06 no no no no up up 18:0/20:4-PC+blood 16:0/18:2-PI+blood -0.622556391 -0.735294118 0 serum_phospholipids serum_phospholipids 0.454 0.269 no no no no no no 18:0/20:4-PC+blood 16:0/20:3-PC+blood 0.521804511 0 0 serum_phospholipids serum_phospholipids 0.454 5.43E-06 no no no no up up 18:0/20:4-PC+blood 16:0/20:4-PC+blood 0.932330827 0.862745098 0.915213675 serum_phospholipids serum_phospholipids 0.454 0.0262 no no no no up no 18:0/20:4-PC+blood 16:0/20:5-PC+blood 0 0.553921569 0 serum_phospholipids serum_phospholipids 0.454 0.628 no no no no no no 18:0/20:4-PC+blood 16:0/20:5-PG+blood 0.590977444 0 0 serum_phospholipids serum_phospholipids 0.454 0.00656 no no no no up no 18:0/20:4-PC+blood 16:0/22:0-PE+blood 0 0.514705882 0 serum_phospholipids serum_phospholipids 0.454 0.00839 no no no dn no up 18:0/20:4-PC+blood 16:0/22:6-PC+blood 0 0.901960784 0 serum_phospholipids serum_phospholipids 0.454 4.53E-05 no no no no up up 18:0/20:4-PC+blood 16:1/16:0-PC+blood 0.587969925 0.642156863 0.465299145 serum_phospholipids serum_phospholipids 0.454 0.0215 no no no no up up 18:0/20:4-PC+blood 16:1/16:1-PC+blood 0.685714286 0.512254902 0 serum_phospholipids serum_phospholipids 0.454 0.0177 no no no no no up 18:0/20:4-PC+blood 18:0-LPA+blood 0 0 -0.462564103 serum_phospholipids serum_phospholipids 0.454 0.0725 no no no no dn no 18:0/20:4-PC+blood 18:0/16:0-PC+blood 0.715789474 0 0 serum_phospholipids serum_phospholipids 0.454 9.64E-07 no no no up up up 18:0/20:4-PC+blood 18:0/18:0-PE+blood 0 -0.718137255 0 serum_phospholipids serum_phospholipids 0.454 0.00896 no no no up up no 18:0/20:4-PC+blood 18:0/18:1-PE+blood 0 -0.742647059 0 serum_phospholipids serum_phospholipids 0.454 0.00716 no no no up up no 18:0/20:4-PC+blood 18:0/18:1-PI+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.454 0.599 no no no no no no 18:0/20:4-PC+blood 18:0/18:2-PC+blood 0.514285714 0 0.546666667 serum_phospholipids serum_phospholipids 0.454 1.74E-06 no no no no up up 18:0/20:4-PC+blood 18:0+blood 0 0 0.456410256 serum_phospholipids serum_fattyacid 0.454 0.344 no no no no no no 18:0/20:4-PC+blood Asthma 0 0 -0.453076923 serum_phospholipids kegg 0.454 NA no no no no no no 18:0/20:4-PC+blood Autophagy - animal 0 0 0.425384615 serum_phospholipids kegg 0.454 NA no no no no no no 18:0/20:4-PC+blood Bacteroides 0 0.517156863 0 LPS-producing serum_phospholipids Genus 0.454 0.000267 no no no dn dn up 18:0/20:4-PC+blood Cholinergic synapse 0 0.526470588 0 serum_phospholipids kegg 0.454 NA no no no no no no 18:0/20:4-PC+blood Diabetic cardiomyopathy 0 0 -0.418461538 serum_phospholipids kegg 0.454 NA no no no no no no 18:0/20:4-PC+blood HCA+stool 0 0 -0.445112782 serum_phospholipids stool_bileacids 0.454 0.155 no no no no no no 18:0/20:4-PC+blood Inflammatory bowel disease 0 0 -0.476153846 serum_phospholipids kegg 0.454 NA no no no no no no 18:0/20:4-PC+blood Intestinal immune network for IgA production 0 0 -0.402307692 serum_phospholipids kegg 0.454 NA no no no no no no 18:0/20:4-PC+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.611764706 0 serum_phospholipids kegg 0.454 NA no no no no no dn 18:0/20:4-PC+blood Lachnospira 0 0 0.489384279 butyrate-producing serum_phospholipids Genus 0.454 0.279 no no no no no no 18:0/20:4-PC+blood MAPK signaling pathway 0 0.576470588 0 serum_phospholipids kegg 0.454 NA no no no no no no 18:0/20:4-PC+blood Parabacteroides 0 0.549019608 0 serum_phospholipids Genus 0.454 4.19E-05 no no no no up up 18:0/20:4-PC+blood Prevotella -0.541432859 0 0 acetate-producing serum_phospholipids Genus 0.454 0.287 no no no no no no 18:0/20:4-PC+blood Prion disease 0 0 -0.417692308 serum_phospholipids kegg 0.454 NA no no no no no no 18:0/20:4-PC+blood Renal cell carcinoma 0 -0.5 0 serum_phospholipids kegg 0.454 NA no no no no no no 18:0/20:4-PC+blood Ruminococcus 0 -0.512569072 0 serum_phospholipids Genus 0.454 0.0679 no no no no no dn 18:0/20:4-PC+blood Shigellosis 0 -0.547058824 0 serum_phospholipids kegg 0.454 NA no no no no no no 18:0/20:4-PC+blood TCA+stool 0 -0.736363636 0 serum_phospholipids stool_bileacids 0.454 0.458 no no no no no no 18:0/20:4-PC+blood Th1 and Th2 cell differentiation 0.484210526 0 0 serum_phospholipids kegg 0.454 NA no no no no no no 18:0/20:4-PC+blood Th17 cell differentiation 0 0 -0.450769231 serum_phospholipids kegg 0.454 NA no no no no no no 18:0/20:4-PI+blood "12,13-EPOME+blood" 0 -0.521101993 0 serum_phospholipids serum_ARA 0.167 0.901 no no no no no no 18:0/20:4-PI+blood 14:0-LPC+blood -0.469172932 0 0 serum_phospholipids serum_phospholipids 0.167 0.00689 no no no up up no 18:0/20:4-PI+blood 14:1/18:2-PG+blood -0.505263158 0 0 serum_phospholipids serum_phospholipids 0.167 0.00259 no no no no up up 18:0/20:4-PI+blood 16:0/18:0-PS+blood 0 0.639705882 0.50017094 serum_phospholipids serum_phospholipids 0.167 0.377 no no no no no no 18:0/20:4-PI+blood 16:0/20:5-PG+blood 0.631578947 0.556372549 0.537094017 serum_phospholipids serum_phospholipids 0.167 0.00656 no no no no up no 18:0/20:4-PI+blood 16:1/16:1-PC+blood 0.553383459 0 0 serum_phospholipids serum_phospholipids 0.167 0.0177 no no no no no up 18:0/20:4-PI+blood 16:1/18:1-PG+blood 0.551879699 0 0.464615385 serum_phospholipids serum_phospholipids 0.167 3.21E-05 no no no no up up 18:0/20:4-PI+blood 16:1/18:2-PG+blood 0 0 0.481709402 serum_phospholipids serum_phospholipids 0.167 1.40E-08 no no no no up up 18:0/20:4-PI+blood 16:1+blood 0.470676692 0 0 yes serum_phospholipids serum_fattyacid 0.167 0.0186 no no no no no dn 18:0/20:4-PI+blood 18:0/18:0-PS+blood 0 0 0.546666667 serum_phospholipids serum_phospholipids 0.167 0.00617 no no no no up no 18:0/20:4-PI+blood 18:0/18:1-PG+blood 0 0 0.605470085 serum_phospholipids serum_phospholipids 0.167 0.000842 no no no no up no 18:0/20:4-PI+blood 18:0/18:2-PI+blood 0 0.490196078 0.472820513 serum_phospholipids serum_phospholipids 0.167 0.179 no no no no no no 18:0/20:4-PI+blood 18:0/20:3-PI+blood 0.720300752 0 0.504273504 serum_phospholipids serum_phospholipids 0.167 0.377 no no no no no no 18:0/20:4-PI+blood 18:0/20:4-PC+blood 0.452631579 0 0 serum_phospholipids serum_phospholipids 0.167 0.454 no no no no no no 18:0/20:4-PI+blood Amyotrophic lateral sclerosis 0 -0.514705882 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Arachidonic acid metabolism 0 0 -0.400769231 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Bifidobacterium 0 -0.589822306 0 acetate-producing serum_phospholipids Genus 0.167 0.105 no no no no dn no 18:0/20:4-PI+blood Biosynthesis of cofactors -0.529824561 0 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Breast cancer 0 0.585294118 0.422307692 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood CA+stool 0 0 -0.520300752 serum_phospholipids stool_bileacids 0.167 0.827 no no no no no no 18:0/20:4-PI+blood cGMP-PKG signaling pathway 0.471929825 0 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Collinsella 0 0 -0.532644831 serum_phospholipids Genus 0.167 0.128 no no no no no no 18:0/20:4-PI+blood Coprococcus 0 0 0.492649573 butyrate-producing serum_phospholipids Genus 0.167 0.612 no no no no no no 18:0/20:4-PI+blood DCA+stool 0 0 0.481203008 serum_phospholipids stool_bileacids 0.167 0.195 no no no no no no 18:0/20:4-PI+blood Fc gamma R-mediated phagocytosis 0.466666667 0 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood FoxO signaling pathway 0 0.635294118 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Gap junction -0.524561404 0 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood "Glycine, serine and threonine metabolism" -0.58245614 0 0 serum_phospholipids kegg 0.167 NA no no no no up no 18:0/20:4-PI+blood HDCA+stool 0 0 0.547368421 serum_phospholipids stool_bileacids 0.167 0.176 no no no no no no 18:0/20:4-PI+blood iso-LCA+stool 0 0 0.458646617 serum_phospholipids stool_bileacids 0.167 0.72 no no no no no no 18:0/20:4-PI+blood Kaposi sarcoma-associated herpesvirus infection -0.603508772 0 0 serum_phospholipids kegg 0.167 NA no no no no no dn 18:0/20:4-PI+blood LCA+stool 0 0 0.544360902 serum_phospholipids stool_bileacids 0.167 0.314 no no no no no no 18:0/20:4-PI+blood Lipid and atherosclerosis 0.526315789 0 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood MAPK signaling pathway 0.457894737 0 0.483846154 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Mitophagy - animal -0.564912281 -0.588235294 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood NOD-like receptor signaling pathway 0.580701754 0 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Olfactory transduction 0.578947368 0 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Parkinson disease 0 -0.55 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Pathways of neurodegeneration - multiple diseases 0 -0.538235294 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Peroxisome 0.459649123 0 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Porphyrin and chlorophyll metabolism -0.542105263 -0.517647059 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Progesterone-mediated oocyte maturation 0.478947368 0 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Propionic acid+stool 0 0 0.482706767 yes serum_phospholipids stool_scfa 0.167 0.0436 no no no dn no up 18:0/20:4-PI+blood Proteoglycans in cancer -0.496491228 0 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Renal cell carcinoma 0 0 0.435384615 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Ruminococcus -0.451528109 0 0 serum_phospholipids Genus 0.167 0.0679 no no no no no dn 18:0/20:4-PI+blood Shigellosis -0.559649123 0 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood TCA+stool 0 0 -0.581954887 serum_phospholipids stool_bileacids 0.167 0.458 no no no no no no 18:0/20:4-PI+blood Thyroid hormone synthesis -0.58245614 0 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Ubiquitin mediated proteolysis -0.536842105 -0.597058824 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:4-PI+blood Vascular smooth muscle contraction 0 -0.617647059 0 serum_phospholipids kegg 0.167 NA no no no no no no 18:0/20:5-PC+blood 11-HETE+blood 0 -0.590784383 0 serum_phospholipids serum_ARA 0.17 0.464 no no no no no no 18:0/20:5-PC+blood 14:0/18:0-PC+blood 0 -0.818627451 0 serum_phospholipids serum_phospholipids 0.17 0.00289 no no no up up no 18:0/20:5-PC+blood 15-HETE+blood 0.569713318 0 0 serum_phospholipids serum_ARA 0.17 0.819 no no no no no no 18:0/20:5-PC+blood 16:0-LPC+blood 0 0 -0.532307692 serum_phospholipids serum_phospholipids 0.17 0.00456 no no no up up no 18:0/20:5-PC+blood 16:0/14:0-PC+blood 0 0 0.652649573 serum_phospholipids serum_phospholipids 0.17 0.0206 no no no no up up 18:0/20:5-PC+blood 16:0/16:0-PC+blood 0 0 0.45025641 serum_phospholipids serum_phospholipids 0.17 0.00079 no no no no up up 18:0/20:5-PC+blood 16:0/16:0-PI+blood -0.542857143 -0.720588235 0 serum_phospholipids serum_phospholipids 0.17 0.358 no no no no no no 18:0/20:5-PC+blood 16:0/16:1-PC+blood 0 -0.821078431 0 serum_phospholipids serum_phospholipids 0.17 0.00283 no no no up up no 18:0/20:5-PC+blood 16:0/16:1-PI+blood -0.589473684 -0.68627451 -0.548717949 serum_phospholipids serum_phospholipids 0.17 0.262 no no no no no no 18:0/20:5-PC+blood 16:0/18:0-PS+blood 0 0 -0.439316239 serum_phospholipids serum_phospholipids 0.17 0.377 no no no no no no 18:0/20:5-PC+blood 16:0/18:1-PC+blood 0.487218045 0 0 serum_phospholipids serum_phospholipids 0.17 6.15E-07 no no no up up up 18:0/20:5-PC+blood 16:0/18:1-PE+blood -0.565413534 -0.691176471 0 serum_phospholipids serum_phospholipids 0.17 0.000107 no no no up up no 18:0/20:5-PC+blood 16:0/18:2-PC+blood 0.52481203 0 0.491282051 serum_phospholipids serum_phospholipids 0.17 3.24E-06 no no no no up up 18:0/20:5-PC+blood 16:0/18:2-PI+blood -0.479699248 -0.767156863 0 serum_phospholipids serum_phospholipids 0.17 0.269 no no no no no no 18:0/20:5-PC+blood 16:0/20:3-PC+blood 0.460150376 0 0 serum_phospholipids serum_phospholipids 0.17 5.43E-06 no no no no up up 18:0/20:5-PC+blood 16:0/20:4-PC+blood 0 0.735294118 0.628717949 serum_phospholipids serum_phospholipids 0.17 0.0262 no no no no up no 18:0/20:5-PC+blood 16:0/20:5-PC+blood 0 0.487745098 0 serum_phospholipids serum_phospholipids 0.17 0.628 no no no no no no 18:0/20:5-PC+blood 16:0/22:0-PE+blood 0.568421053 0 0 serum_phospholipids serum_phospholipids 0.17 0.00839 no no no dn no up 18:0/20:5-PC+blood 16:0/22:6-PC+blood 0.631578947 0.779411765 0.410598291 serum_phospholipids serum_phospholipids 0.17 4.53E-05 no no no no up up 18:0/20:5-PC+blood 16:0+blood 0 0 -0.424957265 yes serum_phospholipids serum_fattyacid 0.17 0.00876 no no no up no no 18:0/20:5-PC+blood 16:1-LPC+blood 0 0 -0.562393162 serum_phospholipids serum_phospholipids 0.17 0.0241 no no no no up no 18:0/20:5-PC+blood 16:1/16:0-PC+blood 0 0.566176471 0.532991453 serum_phospholipids serum_phospholipids 0.17 0.0215 no no no no up up 18:0/20:5-PC+blood 16:1/18:1-PG+blood 0 0 -0.583589744 serum_phospholipids serum_phospholipids 0.17 3.21E-05 no no no no up up 18:0/20:5-PC+blood 16:1/18:2-PG+blood 0 -0.485294118 0 serum_phospholipids serum_phospholipids 0.17 1.40E-08 no no no no up up 18:0/20:5-PC+blood 18:0-LPA+blood 0 0 -0.582222222 serum_phospholipids serum_phospholipids 0.17 0.0725 no no no no dn no 18:0/20:5-PC+blood 18:0/16:0-PC+blood 0.45112782 0 0 serum_phospholipids serum_phospholipids 0.17 9.64E-07 no no no up up up 18:0/20:5-PC+blood 18:0/18:0-PE+blood 0 -0.725490196 0 serum_phospholipids serum_phospholipids 0.17 0.00896 no no no up up no 18:0/20:5-PC+blood 18:0/18:0-PS+blood 0 0 -0.40991453 serum_phospholipids serum_phospholipids 0.17 0.00617 no no no no up no 18:0/20:5-PC+blood 18:0/18:1-PE+blood 0 -0.723039216 0 serum_phospholipids serum_phospholipids 0.17 0.00716 no no no up up no 18:0/20:5-PC+blood 18:0/18:1-PI+blood 0 -0.669117647 -0.526837607 serum_phospholipids serum_phospholipids 0.17 0.599 no no no no no no 18:0/20:5-PC+blood 18:0/18:2-PC+blood 0.54887218 0 0.591111111 serum_phospholipids serum_phospholipids 0.17 1.74E-06 no no no no up up 18:0/20:5-PC+blood 18:0/20:3-PC+blood 0 -0.509803922 0 serum_phospholipids serum_phospholipids 0.17 0.0682 no no no no up no 18:0/20:5-PC+blood 18:0/20:4-PC+blood 0.520300752 0.901960784 0.673846154 serum_phospholipids serum_phospholipids 0.17 0.454 no no no no no no 18:0/20:5-PC+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.484210526 serum_phospholipids stool_cometabolism 0.17 0.33 no no no no no no 18:0/20:5-PC+blood Acetic acid+stool -0.664835165 0 0 yes serum_phospholipids stool_scfa 0.17 0.0656 no no no dn no no 18:0/20:5-PC+blood Aldosterone synthesis and secretion 0 0 -0.513076923 serum_phospholipids kegg 0.17 NA no no no no up up 18:0/20:5-PC+blood Allograft rejection 0.619298246 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Alzheimer disease 0 0 -0.446153846 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Amoebiasis 0.689473684 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Amphetamine addiction 0 0 -0.453846154 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Apelin signaling pathway -0.528070175 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Arrhythmogenic right ventricular cardiomyopathy 0.464912281 0 0 serum_phospholipids kegg 0.17 NA no no no no up up 18:0/20:5-PC+blood Autoimmune thyroid disease 0.619298246 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Autophagy - animal 0 0 0.523076923 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Axon guidance 0 -0.529411765 0 serum_phospholipids kegg 0.17 NA no no no no up up 18:0/20:5-PC+blood Biosynthesis of amino acids 0 0 0.440769231 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Butyric acid+stool -0.598901099 0 0 yes serum_phospholipids stool_scfa 0.17 0.102 no no no dn no no 18:0/20:5-PC+blood CA+stool 0 0 -0.485714286 serum_phospholipids stool_bileacids 0.17 0.827 no no no no no no 18:0/20:5-PC+blood Calcium signaling pathway 0 0 -0.437692308 serum_phospholipids kegg 0.17 NA no no no no up up 18:0/20:5-PC+blood Carbon metabolism 0 0 0.503846154 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Cardiac muscle contraction 0 0 -0.451538462 serum_phospholipids kegg 0.17 NA no no no no no up 18:0/20:5-PC+blood Cell adhesion molecules 0.624561404 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Cell cycle -0.563157895 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Cellular senescence 0.663157895 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Central carbon metabolism in cancer 0 0 0.44 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Chemokine signaling pathway 0.571929825 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Cholinergic synapse 0 0.573529412 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Cytosolic DNA-sensing pathway 0 0 -0.420769231 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Diabetic cardiomyopathy 0 0 -0.466923077 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Dilated cardiomyopathy 0.478947368 0 0 serum_phospholipids kegg 0.17 NA no no no no up up 18:0/20:5-PC+blood Dopaminergic synapse 0 0 -0.468461538 serum_phospholipids kegg 0.17 NA no no no no up no 18:0/20:5-PC+blood Endocytosis 0.680701754 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Epstein-Barr virus infection 0 -0.532352941 -0.411538462 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Fc epsilon RI signaling pathway 0 0 0.413846154 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood FoxO signaling pathway 0 0 0.441538462 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood GCA+stool 0.664835165 0 0 serum_phospholipids stool_bileacids 0.17 0.0809 no no no no no no 18:0/20:5-PC+blood GCDCA+stool 0.593406593 0 0 yes serum_phospholipids stool_bileacids 0.17 0.0471 no no no no dn no 18:0/20:5-PC+blood GnRH signaling pathway 0 0 -0.403076923 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Graft-versus-host disease 0.59122807 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood HCA+stool 0 0 -0.452631579 serum_phospholipids stool_bileacids 0.17 0.155 no no no no no no 18:0/20:5-PC+blood Hepatocellular carcinoma 0.489473684 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Herpes simplex virus 1 infection 0 0 -0.472307692 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Human papillomavirus infection 0.731578947 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Human T-cell leukemia virus 1 infection 0 0 -0.451538462 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Huntington disease 0 0 -0.442307692 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Hypertrophic cardiomyopathy 0.487719298 0 0 serum_phospholipids kegg 0.17 NA no no no no up up 18:0/20:5-PC+blood Inflammatory mediator regulation of TRP channels 0 0 -0.404615385 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Influenza A 0.577192982 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Insulin signaling pathway -0.550877193 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.714705882 0 serum_phospholipids kegg 0.17 NA no no no no no dn 18:0/20:5-PC+blood L-Tryptophan+stool 0.604395604 0 0 serum_phospholipids stool_cometabolism 0.17 0.557 no no no no no no 18:0/20:5-PC+blood Lachnospira 0 0 0.467808905 butyrate-producing serum_phospholipids Genus 0.17 0.279 no no no no no no 18:0/20:5-PC+blood Leukocyte transendothelial migration 0.575438596 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood MAPK signaling pathway 0 0.747058824 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Melanogenesis 0 0 -0.421538462 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Morphine addiction 0 0 -0.428461538 serum_phospholipids kegg 0.17 NA no no no no up up 18:0/20:5-PC+blood mTOR signaling pathway -0.5 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Natural killer cell mediated cytotoxicity 0.684210526 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Neutrophil extracellular trap formation 0.489473684 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Non-alcoholic fatty liver disease 0 -0.573529412 -0.492307692 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Odoribacter -0.444335679 0 0 butyrate-producing serum_phospholipids Genus 0.17 0.798 no no no no no no 18:0/20:5-PC+blood Oocyte meiosis -0.49122807 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Oxidative phosphorylation 0 0 -0.470769231 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood p53 signaling pathway -0.524561404 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Pathogenic Escherichia coli infection 0.521052632 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Peroxisome 0 0 0.443846154 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Phagosome 0.677192982 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Phospholipase D signaling pathway 0.566666667 0 0 serum_phospholipids kegg 0.17 NA no no no no up up 18:0/20:5-PC+blood PI3K-Akt signaling pathway -0.533333333 0 0 yes serum_phospholipids kegg 0.17 NA no no no no up up 18:0/20:5-PC+blood Prion disease 0 0 -0.522307692 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Propionic acid+stool -0.571428571 0 0 yes serum_phospholipids stool_scfa 0.17 0.0436 no no no dn no up 18:0/20:5-PC+blood Protein processing in endoplasmic reticulum -0.471929825 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Rap1 signaling pathway 0.531578947 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Retrograde endocannabinoid signaling 0 0 -0.435384615 serum_phospholipids kegg 0.17 NA no no no no no up 18:0/20:5-PC+blood Ribosome biogenesis in eukaryotes -0.570175439 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood RNA degradation -0.494736842 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Ruminococcus 0 -0.631514527 0 serum_phospholipids Genus 0.17 0.0679 no no no no no dn 18:0/20:5-PC+blood Shigellosis 0 -0.611764706 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Spliceosome -0.48245614 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood TCA+stool 0 -0.754545455 0 serum_phospholipids stool_bileacids 0.17 0.458 no no no no no no 18:0/20:5-PC+blood Thermogenesis 0 0 -0.533076923 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Thyroid hormone signaling pathway 0.459649123 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood total_stool_scfa+stool -0.648351648 0 0 serum_phospholipids stool_scfa 0.17 0.0534 no no no dn no up 18:0/20:5-PC+blood Type I diabetes mellitus 0.619298246 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood UDCA+stool 0 0 -0.476691729 serum_phospholipids stool_bileacids 0.17 0.266 no no no no no no 18:0/20:5-PC+blood Viral carcinogenesis 0.768421053 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/20:5-PC+blood Viral myocarditis 0.612280702 0 0 serum_phospholipids kegg 0.17 NA no no no no no no 18:0/22:6-PA+blood 16:0/16:0-PC+blood 0.45112782 0.546568627 0 serum_phospholipids serum_phospholipids 0.22 0.00079 no no no no up up 18:0/22:6-PA+blood 16:0/18:0-PC+blood 0.457142857 0.732843137 0 serum_phospholipids serum_phospholipids 0.22 0.521 no no no no no no 18:0/22:6-PA+blood 16:0/18:0-PS+blood 0 0.68627451 0 serum_phospholipids serum_phospholipids 0.22 0.377 no no no no no no 18:0/22:6-PA+blood 16:0/18:1-PC+blood 0.45112782 0.50245098 0 serum_phospholipids serum_phospholipids 0.22 6.15E-07 no no no up up up 18:0/22:6-PA+blood 16:0/20:5-PC+blood 0 0.5 0 serum_phospholipids serum_phospholipids 0.22 0.628 no no no no no no 18:0/22:6-PA+blood 16:0/20:5-PG+blood 0 0 0.477606838 serum_phospholipids serum_phospholipids 0.22 0.00656 no no no no up no 18:0/22:6-PA+blood 16:1/16:0-PC+blood 0.569924812 0 0 serum_phospholipids serum_phospholipids 0.22 0.0215 no no no no up up 18:0/22:6-PA+blood 16:1/16:1-PC+blood 0.619548872 0 0 serum_phospholipids serum_phospholipids 0.22 0.0177 no no no no no up 18:0/22:6-PA+blood 16:1/18:1-PG+blood 0.541353383 0 0.476923077 serum_phospholipids serum_phospholipids 0.22 3.21E-05 no no no no up up 18:0/22:6-PA+blood 16:1/18:2-PG+blood 0.452631579 0 0.577435897 serum_phospholipids serum_phospholipids 0.22 1.40E-08 no no no no up up 18:0/22:6-PA+blood 18:0/16:0-PC+blood 0.461654135 0 0 serum_phospholipids serum_phospholipids 0.22 9.64E-07 no no no up up up 18:0/22:6-PA+blood 18:0/18:0-PC+blood 0.485714286 0.600490196 0 serum_phospholipids serum_phospholipids 0.22 0.426 no no no no no no 18:0/22:6-PA+blood 18:0/18:0-PS+blood 0.562406015 0.590686275 0 serum_phospholipids serum_phospholipids 0.22 0.00617 no no no no up no 18:0/22:6-PA+blood 18:0/18:1-PC+blood 0.551879699 0.536764706 0 serum_phospholipids serum_phospholipids 0.22 0.393 no no no no no no 18:0/22:6-PA+blood 18:0/20:4-PI+blood 0 0.595588235 0 serum_phospholipids serum_phospholipids 0.22 0.167 no no no no no no 18:0/22:6-PA+blood Apelin signaling pathway 0 0 0.409230769 serum_phospholipids kegg 0.22 NA no no no no no no 18:0/22:6-PA+blood Apoptosis 0 0 -0.487692308 serum_phospholipids kegg 0.22 NA no no no no no no 18:0/22:6-PA+blood Biosynthesis of amino acids 0 0 -0.442307692 serum_phospholipids kegg 0.22 NA no no no no no no 18:0/22:6-PA+blood Calcium signaling pathway 0 -0.505882353 0 serum_phospholipids kegg 0.22 NA no no no no up up 18:0/22:6-PA+blood Fc gamma R-mediated phagocytosis 0 0 -0.403076923 serum_phospholipids kegg 0.22 NA no no no no no no 18:0/22:6-PA+blood GnRH signaling pathway 0 -0.5 0 serum_phospholipids kegg 0.22 NA no no no no no no 18:0/22:6-PA+blood Lipid and atherosclerosis 0 0 -0.439230769 serum_phospholipids kegg 0.22 NA no no no no no no 18:0/22:6-PA+blood Lysosome 0 0 -0.407692308 serum_phospholipids kegg 0.22 NA no no no no no no 18:0/22:6-PA+blood mRNA surveillance pathway 0 0 0.402307692 serum_phospholipids kegg 0.22 NA no no no no no no 18:0/22:6-PA+blood Neutrophil extracellular trap formation 0 0 -0.410769231 serum_phospholipids kegg 0.22 NA no no no no no no 18:0/22:6-PA+blood nutriCA+stool 0 0.651403561 0 serum_phospholipids stool_bileacids 0.22 0.481 no no no no no no 18:0/22:6-PA+blood Osteoclast differentiation 0 0 -0.456923077 serum_phospholipids kegg 0.22 NA no no no no no no 18:0/22:6-PA+blood Parabacteroides 0.484210526 0 0 serum_phospholipids Genus 0.22 4.19E-05 no no no no up up 18:0/22:6-PA+blood Paraprevotella 0 0 -0.44168631 serum_phospholipids Genus 0.22 0.118 no no no no no no 18:0/22:6-PA+blood Pertussis 0 0 -0.485384615 serum_phospholipids kegg 0.22 NA no no no no no dn 18:0/22:6-PA+blood Ribosome biogenesis in eukaryotes 0 0 0.441538462 serum_phospholipids kegg 0.22 NA no no no no no no 18:0/22:6-PA+blood Small cell lung cancer -0.457894737 0 0 serum_phospholipids kegg 0.22 NA no no no no no up 18:0/22:6-PA+blood Staphylococcus aureus infection 0 0 -0.536153846 serum_phospholipids kegg 0.22 NA no no no up no no 18:0/22:6-PA+blood Systemic lupus erythematosus 0 0 -0.410769231 serum_phospholipids kegg 0.22 NA no no no no no no 18:0/22:6-PA+blood Tuberculosis 0 0 -0.425384615 serum_phospholipids kegg 0.22 NA no no no no no dn 18:0/22:6-PC+blood 14:0/18:2-PC+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.0775 0.102 no no up no up no 18:0/22:6-PC+blood 14:0+blood 0.479699248 0 0 yes serum_phospholipids serum_fattyacid 0.0775 0.00572 no no up up no dn 18:0/22:6-PC+blood 14:1/18:2-PG+blood 0.497744361 0 0 serum_phospholipids serum_phospholipids 0.0775 0.00259 no no up no up up 18:0/22:6-PC+blood 16:0/14:0-PC+blood 0 0 0.42017094 serum_phospholipids serum_phospholipids 0.0775 0.0206 no no up no up up 18:0/22:6-PC+blood 16:0/18:2-PC+blood 0 0 0.578119658 serum_phospholipids serum_phospholipids 0.0775 3.24E-06 no no up no up up 18:0/22:6-PC+blood 16:0/20:5-PC+blood 0 0.553921569 0 serum_phospholipids serum_phospholipids 0.0775 0.628 no no up no no no 18:0/22:6-PC+blood 16:0/22:0-PE+blood 0.735338346 0.678921569 0.513162393 serum_phospholipids serum_phospholipids 0.0775 0.00839 no no up dn no up 18:0/22:6-PC+blood 16:0/22:6-PC+blood 0.821052632 0.784313725 0.824273504 serum_phospholipids serum_phospholipids 0.0775 4.53E-05 no no up no up up 18:0/22:6-PC+blood 16:1/16:0-PC+blood 0 0.740196078 0.649230769 serum_phospholipids serum_phospholipids 0.0775 0.0215 no no up no up up 18:0/22:6-PC+blood 18:0/18:0-PS+blood 0 0.482843137 0 serum_phospholipids serum_phospholipids 0.0775 0.00617 no no up no up no 18:0/22:6-PC+blood 18:0/18:2-PC+blood 0 0 0.532307692 serum_phospholipids serum_phospholipids 0.0775 1.74E-06 no no up no up up 18:0/22:6-PC+blood 18:0/20:4-PC+blood 0 0.602941176 0 serum_phospholipids serum_phospholipids 0.0775 0.454 no no up no no no 18:0/22:6-PC+blood 18:0/20:5-PC+blood 0.458646617 0.590686275 0.457777778 serum_phospholipids serum_phospholipids 0.0775 0.17 no no up no no no 18:0/22:6-PC+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0.71978022 0 0 serum_phospholipids stool_cometabolism 0.0775 0.33 no no up no no no 18:0/22:6-PC+blood AGE-RAGE signaling pathway in diabetic complications 0.557894737 0 0 serum_phospholipids kegg 0.0775 NA no no up no no no 18:0/22:6-PC+blood Alzheimer disease 0 0 -0.439230769 serum_phospholipids kegg 0.0775 NA no no up no no no 18:0/22:6-PC+blood Bacteroides 0 0.534313725 0 LPS-producing serum_phospholipids Genus 0.0775 0.000267 no no up dn dn up 18:0/22:6-PC+blood Blautia 0 0 -0.549231362 acetate-producing serum_phospholipids Genus 0.0775 1.36E-05 no no up up dn dn 18:0/22:6-PC+blood cAMP signaling pathway 0 -0.647058824 0 yes serum_phospholipids kegg 0.0775 NA no no up no up up 18:0/22:6-PC+blood Cardiac muscle contraction 0 0 -0.416153846 serum_phospholipids kegg 0.0775 NA no no up no no up 18:0/22:6-PC+blood Clostridium 0.522000789 0 0 serum_phospholipids Genus 0.0775 0.925 no no up no no no 18:0/22:6-PC+blood Ferroptosis 0 -0.514705882 0 serum_phospholipids kegg 0.0775 NA no no up no no no 18:0/22:6-PC+blood GnRH signaling pathway 0.473684211 0 0 serum_phospholipids kegg 0.0775 NA no no up no no no 18:0/22:6-PC+blood Huntington disease 0 0 -0.42 serum_phospholipids kegg 0.0775 NA no no up no no no 18:0/22:6-PC+blood Intestinal immune network for IgA production 0 0 -0.402307692 serum_phospholipids kegg 0.0775 NA no no up no no no 18:0/22:6-PC+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.776470588 0 serum_phospholipids kegg 0.0775 NA no no up no no dn 18:0/22:6-PC+blood L-Tryptophan+stool 0 0 0.472180451 serum_phospholipids stool_cometabolism 0.0775 0.557 no no up no no no 18:0/22:6-PC+blood Malaria 0 -0.632352941 0 serum_phospholipids kegg 0.0775 NA no no up no no no 18:0/22:6-PC+blood Mineral absorption 0 -0.591176471 0 serum_phospholipids kegg 0.0775 NA no no up no no no 18:0/22:6-PC+blood Necroptosis 0 -0.676470588 0 serum_phospholipids kegg 0.0775 NA no no up no no no 18:0/22:6-PC+blood Peroxisome 0 0 0.408461538 serum_phospholipids kegg 0.0775 NA no no up no no no 18:0/22:6-PC+blood Prevotella -0.520988072 0 0 serum_phospholipids Genus 0.0775 0.367 no no up no no no 18:0/22:6-PC+blood Prion disease 0 0 -0.449230769 serum_phospholipids kegg 0.0775 NA no no up no no no 18:0/22:6-PC+blood Retrograde endocannabinoid signaling 0 0 -0.410769231 serum_phospholipids kegg 0.0775 NA no no up no no up 18:0/22:6-PC+blood Shigellosis 0 -0.588235294 0 serum_phospholipids kegg 0.0775 NA no no up no no no 18:0/22:6-PE+blood 12-ketoDCA+blood 0 -0.576306805 0 serum_phospholipids serum_bileacids 0.00022 0.517 up up no no no no 18:0/22:6-PE+blood 12-ketoDCA+stool 0 0 0.559398496 serum_phospholipids stool_bileacids 0.00022 0.505 up up no no no no 18:0/22:6-PE+blood 13-HODE+blood -0.45112782 0 0 serum_phospholipids serum_ARA 0.00022 0.32 up up no no no no 18:0/22:6-PE+blood 16:0-LPE+blood 0.563909774 0 0 serum_phospholipids serum_phospholipids 0.00022 0.0711 up up no up up no 18:0/22:6-PE+blood 16:0/16:0-PI+blood 0.523308271 0 0 serum_phospholipids serum_phospholipids 0.00022 0.358 up up no no no no 18:0/22:6-PE+blood 16:0/18:0-PS+blood 0.807518797 0.740196078 0.563760684 serum_phospholipids serum_phospholipids 0.00022 0.377 up up no no no no 18:0/22:6-PE+blood 16:0/18:1-PE+blood 0.615037594 0 0.746324786 serum_phospholipids serum_phospholipids 0.00022 0.000107 up up no up up no 18:0/22:6-PE+blood 16:0/20:3-PC+blood -0.482706767 0 0 serum_phospholipids serum_phospholipids 0.00022 5.43E-06 up up no no up up 18:0/22:6-PE+blood 16:0/20:4-PC+blood -0.466165414 0 0 serum_phospholipids serum_phospholipids 0.00022 0.0262 up up no no up no 18:0/22:6-PE+blood 16:0/20:4-PE+blood 0.631578947 0 0.744957265 serum_phospholipids serum_phospholipids 0.00022 0.00139 up up no up up no 18:0/22:6-PE+blood 16:0/20:5-PC+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 0.00022 0.628 up up no no no no 18:0/22:6-PE+blood 16:0/22:6-PE+blood 0.864661654 0.794117647 0.820854701 serum_phospholipids serum_phospholipids 0.00022 0.000934 up up no up up no 18:0/22:6-PE+blood 16:1+blood 0 0.490196078 0 yes serum_phospholipids serum_fattyacid 0.00022 0.0186 up up no no no dn 18:0/22:6-PE+blood 18:0-LPE+blood 0.621052632 0 0 serum_phospholipids serum_phospholipids 0.00022 0.491 up up no no no no 18:0/22:6-PE+blood 18:0/18:0-PE+blood 0.64962406 0 0 serum_phospholipids serum_phospholipids 0.00022 0.00896 up up no up up no 18:0/22:6-PE+blood 18:0/18:0-PS+blood 0.685714286 0.784313725 0.636923077 serum_phospholipids serum_phospholipids 0.00022 0.00617 up up no no up no 18:0/22:6-PE+blood 18:0/18:1-PE+blood 0.65112782 0 0 serum_phospholipids serum_phospholipids 0.00022 0.00716 up up no up up no 18:0/22:6-PE+blood 18:0/20:2-PC+blood 0 0 -0.463931624 serum_phospholipids serum_phospholipids 0.00022 0.733 up up no no no no 18:0/22:6-PE+blood 18:0/22:6-PC+blood 0 0.642156863 0.423589744 serum_phospholipids serum_phospholipids 0.00022 0.0775 up up no no no up 18:0/22:6-PE+blood Adipocytokine signaling pathway -0.524561404 -0.573529412 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Akkermansia 0 0 0.414823599 acetate-producing serum_phospholipids Genus 0.00022 0.23 up up no no no no 18:0/22:6-PE+blood Amoebiasis 0 0 0.404615385 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Asthma -0.645614035 0 -0.403846154 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Bacteroides 0 0.487745098 0 LPS-producing serum_phospholipids Genus 0.00022 0.000267 up up no dn dn up 18:0/22:6-PE+blood cAMP signaling pathway 0 -0.602941176 0 yes serum_phospholipids kegg 0.00022 NA up up no no up up 18:0/22:6-PE+blood cGMP-PKG signaling pathway 0 0 0.535384615 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Cholinergic synapse 0 0.508823529 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Chronic myeloid leukemia 0 -0.652941176 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Clostridium 0 0.586664893 0 serum_phospholipids Genus 0.00022 0.925 up up no no no no 18:0/22:6-PE+blood Cytosolic DNA-sensing pathway 0 -0.741176471 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Dorea 0 0 -0.414753727 serum_phospholipids Genus 0.00022 0.00362 up up no up no dn 18:0/22:6-PE+blood Epithelial cell signaling in Helicobacter pylori infection 0 0 0.465384615 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Estrogen signaling pathway 0.473684211 0 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Fc gamma R-mediated phagocytosis 0 0 0.427692308 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood GCA+stool 0.681318681 0 0 serum_phospholipids stool_bileacids 0.00022 0.0809 up up no no no no 18:0/22:6-PE+blood GDCA+stool 0 0 -0.445783638 serum_phospholipids stool_bileacids 0.00022 0.656 up up no no no no 18:0/22:6-PE+blood Hematopoietic cell lineage 0 0 -0.439230769 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Hepatitis C 0 -0.755882353 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Human papillomavirus infection 0 0 0.451538462 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood IL-17 signaling pathway 0 0 0.536153846 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Inflammatory bowel disease -0.663157895 0 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Insulin resistance 0 -0.567647059 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Intestinal immune network for IgA production -0.826315789 0 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Kaposi sarcoma-associated herpesvirus infection -0.485964912 -0.605882353 0 serum_phospholipids kegg 0.00022 NA up up no no no dn 18:0/22:6-PE+blood Lachnospira 0.565413534 0 0 butyrate-producing serum_phospholipids Genus 0.00022 0.279 up up no no no no 18:0/22:6-PE+blood Lipid and atherosclerosis 0 0 0.539230769 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Longevity regulating pathway - multiple species 0.545614035 0 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood MAPK signaling pathway 0.503508772 0 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Measles 0 -0.55 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Neurotrophin signaling pathway 0 -0.608823529 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Olfactory transduction 0.470175439 0 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Osteoclast differentiation 0 0 0.428461538 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.538235294 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Peroxisome 0 0 0.447692308 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Pertussis 0 0 0.431538462 serum_phospholipids kegg 0.00022 NA up up no no no dn 18:0/22:6-PE+blood Platinum drug resistance 0 0 -0.416923077 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood PPAR signaling pathway 0 0 0.543846154 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Primary immunodeficiency 0.545614035 0 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Propionic acid+stool 0 0 0.515789474 yes serum_phospholipids stool_scfa 0.00022 0.0436 up up no dn no up 18:0/22:6-PE+blood Prostate cancer 0 -0.594117647 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Relaxin signaling pathway 0 -0.529411765 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Rheumatoid arthritis -0.457894737 0 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Small cell lung cancer 0 -0.582352941 0 serum_phospholipids kegg 0.00022 NA up up no no no up 18:0/22:6-PE+blood T cell receptor signaling pathway 0 -0.6 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Th1 and Th2 cell differentiation -0.656140351 0 -0.533076923 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Th17 cell differentiation -0.654385965 -0.576470588 -0.513076923 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood TNF signaling pathway 0 -0.502941176 0 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PE+blood Viral carcinogenesis 0 0 0.409230769 serum_phospholipids kegg 0.00022 NA up up no no no no 18:0/22:6-PI+blood 12-ketoDCA+blood 0 -0.559840896 0 serum_phospholipids serum_bileacids 0.425 0.517 no no no no no no 18:0/22:6-PI+blood 14:0/18:2-PC+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.425 0.102 no no no no up no 18:0/22:6-PI+blood 14:0+blood 0.57443609 0 0 yes serum_phospholipids serum_fattyacid 0.425 0.00572 no no no up no dn 18:0/22:6-PI+blood 15-HETE+blood 0 0 -0.416277266 serum_phospholipids serum_ARA 0.425 0.819 no no no no no no 18:0/22:6-PI+blood 16:0/16:0-PI+blood 0.633082707 0 0.469401709 serum_phospholipids serum_phospholipids 0.425 0.358 no no no no no no 18:0/22:6-PI+blood 16:0/18:0-PS+blood 0 0.718137255 0 serum_phospholipids serum_phospholipids 0.425 0.377 no no no no no no 18:0/22:6-PI+blood 16:0/18:2-PI+blood 0.621052632 0 0 serum_phospholipids serum_phospholipids 0.425 0.269 no no no no no no 18:0/22:6-PI+blood 16:0/20:4-PC+blood -0.478195489 0 -0.40034188 serum_phospholipids serum_phospholipids 0.425 0.0262 no no no no up no 18:0/22:6-PI+blood 16:0/20:4-PI+blood 0.545864662 0 0 serum_phospholipids serum_phospholipids 0.425 0.558 no no no no no no 18:0/22:6-PI+blood 16:0/22:0-PE+blood 0 0.549019608 0 serum_phospholipids serum_phospholipids 0.425 0.00839 no no no dn no up 18:0/22:6-PI+blood 16:0/22:6-PC+blood 0 0.549019608 0 serum_phospholipids serum_phospholipids 0.425 4.53E-05 no no no no up up 18:0/22:6-PI+blood 16:0/22:6-PE+blood 0 0.524509804 0 serum_phospholipids serum_phospholipids 0.425 0.000934 no no no up up no 18:0/22:6-PI+blood 16:1-LPC+blood 0 0 0.436581197 serum_phospholipids serum_phospholipids 0.425 0.0241 no no no no up no 18:0/22:6-PI+blood 16:1/16:0-PC+blood 0 0.546568627 0 serum_phospholipids serum_phospholipids 0.425 0.0215 no no no no up up 18:0/22:6-PI+blood 16:1/16:1-PC+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.425 0.0177 no no no no no up 18:0/22:6-PI+blood 18:0-LPC+blood 0.509774436 0 0 serum_phospholipids serum_phospholipids 0.425 0.554 no no no no no no 18:0/22:6-PI+blood 18:0-LPE+blood 0.45112782 0 0 serum_phospholipids serum_phospholipids 0.425 0.491 no no no no no no 18:0/22:6-PI+blood 18:0/18:0-PS+blood 0 0.674019608 0 serum_phospholipids serum_phospholipids 0.425 0.00617 no no no no up no 18:0/22:6-PI+blood 18:0/18:1-PI+blood 0 0 0.466666667 serum_phospholipids serum_phospholipids 0.425 0.599 no no no no no no 18:0/22:6-PI+blood 18:0/18:2-PI+blood 0 0 0.491282051 serum_phospholipids serum_phospholipids 0.425 0.179 no no no no no no 18:0/22:6-PI+blood 18:0/20:4-PI+blood 0 0.492647059 0 serum_phospholipids serum_phospholipids 0.425 0.167 no no no no no no 18:0/22:6-PI+blood 18:0/22:6-PA+blood 0 0.512254902 0.459145299 serum_phospholipids serum_phospholipids 0.425 0.22 no no no no no no 18:0/22:6-PI+blood 18:0/22:6-PC+blood 0.589473684 0.845588235 0 serum_phospholipids serum_phospholipids 0.425 0.0775 no no no no no up 18:0/22:6-PI+blood 18:0/22:6-PE+blood 0.55037594 0.803921569 0 serum_phospholipids serum_phospholipids 0.425 0.00022 no no no up up no 18:0+blood 14:0/16:0-PC+blood 0 0.482843137 0 serum_fattyacid serum_phospholipids 0.344 0.0358 no no no no up no 18:0+blood 14:0/18:2-PC+blood 0 0.524509804 0 serum_fattyacid serum_phospholipids 0.344 0.102 no no no no up no 18:0+blood 14:0+blood 0.565413534 0.504901961 0 yes serum_fattyacid serum_fattyacid 0.344 0.00572 no no no up no dn 18:0+blood 16:0/14:0-PC+blood 0 0 0.485128205 serum_fattyacid serum_phospholipids 0.344 0.0206 no no no no up up 18:0+blood 16:0/16:0-PC+blood 0 0 0.539145299 serum_fattyacid serum_phospholipids 0.344 0.00079 no no no no up up 18:0+blood 16:0/20:4-PC+blood 0 0 0.405128205 serum_fattyacid serum_phospholipids 0.344 0.0262 no no no no up no 18:0+blood 16:0+blood 0.714285714 0.517156863 0 yes serum_fattyacid serum_fattyacid 0.344 0.00876 no no no up no no 18:0+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0.686813187 0 0 serum_fattyacid stool_cometabolism 0.344 0.33 no no no no no no 18:0+blood Acetic acid+stool 0 -0.763636364 0 yes serum_fattyacid stool_scfa 0.344 0.0656 no no no dn no no 18:0+blood Adherens junction 0 0 -0.56 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood AGE-RAGE signaling pathway in diabetic complications 0.554385965 0 0 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Alzheimer disease 0 0 -0.589230769 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Amyotrophic lateral sclerosis 0 0 -0.609230769 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.557692308 serum_fattyacid kegg 0.344 NA no no no no up up 18:0+blood Bacterial invasion of epithelial cells 0 0 -0.553846154 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Biosynthesis of cofactors 0 0 0.406153846 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Butyricimonas 0 0.525712696 0 butyrate-producing serum_fattyacid Genus 0.344 0.17 no no no no no no 18:0+blood Cardiac muscle contraction 0 0 -0.621538462 serum_fattyacid kegg 0.344 NA no no no no no up 18:0+blood Central carbon metabolism in cancer 0.473684211 0 0 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Chronic myeloid leukemia 0 0 0.514615385 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Collinsella 0 0 -0.532644831 serum_fattyacid Genus 0.344 0.128 no no no no no no 18:0+blood Cytokine-cytokine receptor interaction 0 0 -0.476923077 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Cytosolic DNA-sensing pathway -0.571929825 0 0 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Diabetic cardiomyopathy 0 0 -0.629230769 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Dilated cardiomyopathy 0 0 -0.488461538 serum_fattyacid kegg 0.344 NA no no no no up up 18:0+blood Focal adhesion 0 0 -0.582307692 serum_fattyacid kegg 0.344 NA no no no no up up 18:0+blood Gastric acid secretion 0 0 -0.497692308 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Glioma 0.48245614 0 0 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood "Glycine, serine and threonine metabolism" 0 0 0.420769231 serum_fattyacid kegg 0.344 NA no no no no up no 18:0+blood Hepatitis B 0 0 0.431538462 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Hepatocellular carcinoma 0 0 -0.450769231 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Hippo signaling pathway 0 0 -0.596153846 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Huntington disease 0 0 -0.623076923 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Hypertrophic cardiomyopathy 0 0 -0.538461538 serum_fattyacid kegg 0.344 NA no no no no up up 18:0+blood Insulin resistance 0 0 0.416153846 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood L-Phenylalanine+stool 0 -0.645454545 0 serum_fattyacid stool_cometabolism 0.344 0.398 no no no no no no 18:0+blood Lachnospira 0 0 0.411986905 butyrate-producing serum_fattyacid Genus 0.344 0.279 no no no no no no 18:0+blood NF-kappa B signaling pathway 0 0 0.610769231 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Non-alcoholic fatty liver disease 0 0 -0.453846154 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood nutriCA+stool 0 0 -0.445112782 serum_fattyacid stool_bileacids 0.344 0.481 no no no no no no 18:0+blood Oxidative phosphorylation 0 0 -0.623076923 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Phenylacetic acid+stool 0 -0.609090909 0 serum_fattyacid stool_cometabolism 0.344 0.785 no no no no no no 18:0+blood Platelet activation 0 0 -0.437692308 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Prevotella 0 0.556188795 0 acetate-producing serum_fattyacid Genus 0.344 0.287 no no no no no no 18:0+blood Prion disease 0 0 -0.667692308 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Prolactin signaling pathway 0 0 0.42 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Purine metabolism 0 0 0.417692308 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Rap1 signaling pathway 0 0 -0.444615385 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Regulation of actin cytoskeleton 0 0 -0.58 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Retrograde endocannabinoid signaling 0 0 -0.469230769 serum_fattyacid kegg 0.344 NA no no no no no up 18:0+blood RIG-I-like receptor signaling pathway 0 0 0.543076923 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Small cell lung cancer 0 0 0.426923077 serum_fattyacid kegg 0.344 NA no no no no no up 18:0+blood Thermogenesis 0 0 -0.553846154 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Thyroid hormone signaling pathway 0 0 -0.473076923 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood Tight junction 0 0 -0.410769231 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood TNF signaling pathway 0 0 0.476153846 serum_fattyacid kegg 0.344 NA no no no no no no 18:0+blood total_stool_scfa+stool 0 -0.681818182 0 serum_fattyacid stool_scfa 0.344 0.0534 no no no dn no up 18:0+blood Viral protein interaction with cytokine and cytokine receptor 0 0 -0.420769231 serum_fattyacid kegg 0.344 NA no no no no no no 18:1-LPC+blood 12-ketoDCA+blood -0.520550494 0 0 serum_phospholipids serum_bileacids 0.179 0.517 no no no no no no 18:1-LPC+blood "12,13-EPOME+blood" 0 -0.683946366 0 serum_phospholipids serum_ARA 0.179 0.901 no no no no no no 18:1-LPC+blood 14:0-LPC+blood -0.47518797 0 0 serum_phospholipids serum_phospholipids 0.179 0.00689 no no no up up no 18:1-LPC+blood 14:0/16:0-PC+blood -0.545864662 -0.566176471 0 serum_phospholipids serum_phospholipids 0.179 0.0358 no no no no up no 18:1-LPC+blood 14:0/18:0-PC+blood 0 -0.546568627 0 serum_phospholipids serum_phospholipids 0.179 0.00289 no no no up up no 18:1-LPC+blood 14:0/20:4-PC+blood -0.49924812 0 0 serum_phospholipids serum_phospholipids 0.179 0.486 no no no no no no 18:1-LPC+blood 14:1/18:2-PG+blood -0.562406015 0 0 serum_phospholipids serum_phospholipids 0.179 0.00259 no no no no up up 18:1-LPC+blood 16:0/16:0-PI+blood -0.460150376 0 -0.52957265 serum_phospholipids serum_phospholipids 0.179 0.358 no no no no no no 18:1-LPC+blood 16:0/16:1-PC+blood 0 -0.553921569 0 serum_phospholipids serum_phospholipids 0.179 0.00283 no no no up up no 18:1-LPC+blood 16:0/16:1-PI+blood -0.569924812 0 -0.403760684 serum_phospholipids serum_phospholipids 0.179 0.262 no no no no no no 18:1-LPC+blood 16:0/18:0-PS+blood 0 0 -0.408547009 serum_phospholipids serum_phospholipids 0.179 0.377 no no no no no no 18:1-LPC+blood 16:0/18:1-PE+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 0.179 0.000107 no no no up up no 18:1-LPC+blood 16:0/18:2-PI+blood -0.446616541 -0.615196078 0 serum_phospholipids serum_phospholipids 0.179 0.269 no no no no no no 18:1-LPC+blood 16:0/20:4-PI+blood -0.487218045 0 -0.414017094 serum_phospholipids serum_phospholipids 0.179 0.558 no no no no no no 18:1-LPC+blood 16:0/20:5-PC+blood -0.65112782 0 0 serum_phospholipids serum_phospholipids 0.179 0.628 no no no no no no 18:1-LPC+blood 18:0-LPC+blood 0 0 0.558290598 serum_phospholipids serum_phospholipids 0.179 0.554 no no no no no no 18:1-LPC+blood 18:0/18:0-PC+blood 0 0 0.485811966 serum_phospholipids serum_phospholipids 0.179 0.426 no no no no no no 18:1-LPC+blood 18:0/18:0-PS+blood 0 0 -0.414700855 serum_phospholipids serum_phospholipids 0.179 0.00617 no no no no up no 18:1-LPC+blood 18:0/18:1-PC+blood 0 0 0.499487179 serum_phospholipids serum_phospholipids 0.179 0.393 no no no no no no 18:1-LPC+blood 18:0/18:1-PG+blood 0 0 -0.539145299 serum_phospholipids serum_phospholipids 0.179 0.000842 no no no no up no 18:1-LPC+blood 18:0/20:2-PC+blood 0 0 0.631452991 serum_phospholipids serum_phospholipids 0.179 0.733 no no no no no no 18:1-LPC+blood 18:0/20:4-PI+blood 0.485714286 0 0 serum_phospholipids serum_phospholipids 0.179 0.167 no no no no no no 18:1-LPC+blood 18:0/22:6-PE+blood 0 -0.482843137 -0.405128205 serum_phospholipids serum_phospholipids 0.179 0.00022 no no no up up no 18:1-LPC+blood Acetic acid+stool 0 0.736363636 0 yes serum_phospholipids stool_scfa 0.179 0.0656 no no no dn no no 18:1-LPC+blood Adlercreutzia 0 0 0.529449482 serum_phospholipids Genus 0.179 0.548 no no no no no no 18:1-LPC+blood Anaerostipes -0.477756755 0 0 butyrate-producing serum_phospholipids Genus 0.179 0.568 no no no no no no 18:1-LPC+blood Asthma 0 0 0.413076923 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood B cell receptor signaling pathway 0.566666667 0 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood Biosynthesis of cofactors -0.645614035 0 -0.401538462 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood cAMP signaling pathway 0.464912281 0 0 yes serum_phospholipids kegg 0.179 NA no no no no up up 18:1-LPC+blood Cardiac muscle contraction 0.507017544 0 0 serum_phospholipids kegg 0.179 NA no no no no no up 18:1-LPC+blood Collinsella -0.655121225 0 0 serum_phospholipids Genus 0.179 0.128 no no no no no no 18:1-LPC+blood Coprococcus -0.583458647 0 0 butyrate-producing serum_phospholipids Genus 0.179 0.612 no no no no no no 18:1-LPC+blood Cytosolic DNA-sensing pathway 0 0 -0.428461538 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood Diabetic cardiomyopathy 0.480701754 0 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood Fc epsilon RI signaling pathway 0.501754386 0 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood Gemmiger 0 0 -0.44726093 butyrate-producing serum_phospholipids Genus 0.179 0.595 no no no no no no 18:1-LPC+blood "Glycine, serine and threonine metabolism" -0.654385965 0 0 serum_phospholipids kegg 0.179 NA no no no no up no 18:1-LPC+blood HDCA+stool 0 0 -0.631578947 serum_phospholipids stool_bileacids 0.179 0.176 no no no no no no 18:1-LPC+blood Hematopoietic cell lineage 0 0 0.476923077 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood Inflammatory bowel disease 0 -0.517647059 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood Intestinal immune network for IgA production 0 0 0.406923077 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood Lachnospira -0.520300752 0 0 butyrate-producing serum_phospholipids Genus 0.179 0.279 no no no no no no 18:1-LPC+blood Measles 0 0 -0.413846154 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood Neurotrophin signaling pathway 0.5 0 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood Pathways in cancer 0 0.535294118 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood Phenylacetic acid+stool 0.56043956 0 0 serum_phospholipids stool_cometabolism 0.179 0.785 no no no no no no 18:1-LPC+blood Porphyrin and chlorophyll metabolism -0.624561404 0 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood Purine metabolism 0 0 -0.474615385 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood Ruminococcus 0 -0.605763449 0 serum_phospholipids Genus 0.179 0.0679 no no no no no dn 18:1-LPC+blood Sphingolipid signaling pathway 0.528070175 0 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood Th1 and Th2 cell differentiation 0.577192982 0 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood Th17 cell differentiation 0.545614035 0 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPC+blood total_stool_scfa+stool 0 0.772727273 0 serum_phospholipids stool_scfa 0.179 0.0534 no no no dn no up 18:1-LPC+blood VEGF signaling pathway 0.461403509 0 0 serum_phospholipids kegg 0.179 NA no no no no no no 18:1-LPE+blood 16:0/18:1-PC+blood -0.455639098 0 0 serum_phospholipids serum_phospholipids 0.117 6.15E-07 no no no up up up 18:1-LPE+blood 16:0/18:2-PC+blood -0.467669173 0 0 serum_phospholipids serum_phospholipids 0.117 3.24E-06 no no no no up up 18:1-LPE+blood 16:0/20:4-PC+blood -0.485714286 0 0 serum_phospholipids serum_phospholipids 0.117 0.0262 no no no no up no 18:1-LPE+blood 16:0/20:5-PC+blood 0 -0.593137255 0 serum_phospholipids serum_phospholipids 0.117 0.628 no no no no no no 18:1-LPE+blood 16:0/22:0-PE+blood -0.587969925 -0.49754902 0 serum_phospholipids serum_phospholipids 0.117 0.00839 no no no dn no up 18:1-LPE+blood 16:0/22:6-PC+blood -0.670676692 0 0 serum_phospholipids serum_phospholipids 0.117 4.53E-05 no no no no up up 18:1-LPE+blood 16:0+blood 0 0 -0.410598291 yes serum_phospholipids serum_fattyacid 0.117 0.00876 no no no up no no 18:1-LPE+blood 16:1/16:0-PC+blood -0.640601504 0 0 serum_phospholipids serum_phospholipids 0.117 0.0215 no no no no up up 18:1-LPE+blood 16:1/16:1-PC+blood -0.593984962 0 0 serum_phospholipids serum_phospholipids 0.117 0.0177 no no no no no up 18:1-LPE+blood 18:0-LPE+blood 0 0 0.446837607 serum_phospholipids serum_phospholipids 0.117 0.491 no no no no no no 18:1-LPE+blood 18:0/16:0-PC+blood -0.461654135 0 0 serum_phospholipids serum_phospholipids 0.117 9.64E-07 no no no up up up 18:1-LPE+blood 18:0/18:1-PG+blood 0 0 -0.433846154 serum_phospholipids serum_phospholipids 0.117 0.000842 no no no no up no 18:1-LPE+blood 18:0/20:4-PC+blood -0.530827068 0 0 serum_phospholipids serum_phospholipids 0.117 0.454 no no no no no no 18:1-LPE+blood 18:0/20:4-PI+blood 0 0 -0.513846154 serum_phospholipids serum_phospholipids 0.117 0.167 no no no no no no 18:1-LPE+blood 18:0/20:5-PC+blood -0.515789474 0 0 serum_phospholipids serum_phospholipids 0.117 0.17 no no no no no no 18:1-LPE+blood 18:0/22:6-PA+blood -0.529323308 0 0 serum_phospholipids serum_phospholipids 0.117 0.22 no no no no no no 18:1-LPE+blood 18:0/22:6-PC+blood -0.569924812 -0.522058824 0 serum_phospholipids serum_phospholipids 0.117 0.0775 no no no no no up 18:1-LPE+blood 18:0/22:6-PI+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.117 0.425 no no no no no no 18:1-LPE+blood 18:1-LPC+blood 0 0 0.656752137 serum_phospholipids serum_phospholipids 0.117 0.179 no no no no no no 18:1-LPE+blood 4-hydroxybenzoic acid+stool 0 0 0.542857143 serum_phospholipids stool_cometabolism 0.117 0.0536 no no no no dn no 18:1-LPE+blood Arginine and proline metabolism 0 0 -0.442307692 serum_phospholipids kegg 0.117 NA no no no no up no 18:1-LPE+blood Bifidobacterium -0.510718351 0 0 acetate-producing serum_phospholipids Genus 0.117 0.105 no no no no dn no 18:1-LPE+blood Blautia -0.446616541 0 0 acetate-producing serum_phospholipids Genus 0.117 1.36E-05 no no no up dn dn 18:1-LPE+blood CDCA+stool 0 0 0.517293233 serum_phospholipids stool_bileacids 0.117 0.663 no no no no no no 18:1-LPE+blood HDCA+stool 0 0 -0.598496241 serum_phospholipids stool_bileacids 0.117 0.176 no no no no no no 18:1-LPE+blood iso-LCA+stool 0 0 -0.470676692 serum_phospholipids stool_bileacids 0.117 0.72 no no no no no no 18:1-LPE+blood nutriCA+stool 0 0 0.554887218 serum_phospholipids stool_bileacids 0.117 0.481 no no no no no no 18:1-LPE+blood Oscillospira 0 0 -0.47965812 LPS-producing serum_phospholipids Genus 0.117 0.62 no no no no no no 18:1-LPE+blood Paraprevotella -0.449779648 0 0 serum_phospholipids Genus 0.117 0.118 no no no no no no 18:1-LPE+blood Phenylacetic acid+stool 0 0 -0.609022556 serum_phospholipids stool_cometabolism 0.117 0.785 no no no no no no 18:1-LPE+blood Prevotella 0.443839162 0 0 acetate-producing serum_phospholipids Genus 0.117 0.287 no no no no no no 18:1-LPE+blood Purine metabolism 0 0 -0.441538462 serum_phospholipids kegg 0.117 NA no no no no no no 18:1-LPE+blood UDCA+stool 0 0 0.446616541 serum_phospholipids stool_bileacids 0.117 0.266 no no no no no no 18:1/16:0-PC+blood 13-HODE+blood 0 0.56372549 0 serum_phospholipids serum_ARA 2.43E-05 0.32 no up up no no no 18:1/16:0-PC+blood 14:0/18:2-PC+blood 0 0 -0.48034188 serum_phospholipids serum_phospholipids 2.43E-05 0.102 no up up no up no 18:1/16:0-PC+blood 14:0/20:4-PC+blood 0 0 -0.63008547 serum_phospholipids serum_phospholipids 2.43E-05 0.486 no up up no no no 18:1/16:0-PC+blood 14:1/18:2-PG+blood 0 0 -0.457777778 serum_phospholipids serum_phospholipids 2.43E-05 0.00259 no up up no up up 18:1/16:0-PC+blood 16:0-LPE+blood -0.481203008 0 0 serum_phospholipids serum_phospholipids 2.43E-05 0.0711 no up up up up no 18:1/16:0-PC+blood 16:0/14:0-PC+blood 0.603007519 0.713235294 0.706666667 serum_phospholipids serum_phospholipids 2.43E-05 0.0206 no up up no up up 18:1/16:0-PC+blood 16:0/16:0-PC+blood 0.547368421 0.691176471 0.517948718 serum_phospholipids serum_phospholipids 2.43E-05 0.00079 no up up no up up 18:1/16:0-PC+blood 16:0/16:0-PI+blood -0.514285714 0 0 serum_phospholipids serum_phospholipids 2.43E-05 0.358 no up up no no no 18:1/16:0-PC+blood 16:0/16:1-PI+blood -0.554887218 0 0 serum_phospholipids serum_phospholipids 2.43E-05 0.262 no up up no no no 18:1/16:0-PC+blood 16:0/18:1-PC+blood 0.872180451 0.901960784 0.703931624 serum_phospholipids serum_phospholipids 2.43E-05 6.15E-07 no up up up up up 18:1/16:0-PC+blood 16:0/18:1-PE+blood -0.658646617 0 0 serum_phospholipids serum_phospholipids 2.43E-05 0.000107 no up up up up no 18:1/16:0-PC+blood 16:0/18:2-PC+blood 0.987969925 0.992647059 0.995897436 serum_phospholipids serum_phospholipids 2.43E-05 3.24E-06 no up up no up up 18:1/16:0-PC+blood 16:0/18:2-PI+blood -0.457142857 0 0 serum_phospholipids serum_phospholipids 2.43E-05 0.269 no up up no no no 18:1/16:0-PC+blood 16:0/20:3-PC+blood 0.67518797 0.509803922 0.450940171 serum_phospholipids serum_phospholipids 2.43E-05 5.43E-06 no up up no up up 18:1/16:0-PC+blood 16:0/20:4-PC+blood 0.676691729 0.5 0.552820513 serum_phospholipids serum_phospholipids 2.43E-05 0.0262 no up up no up no 18:1/16:0-PC+blood 16:0/20:4-PI+blood -0.49924812 -0.602941176 0 serum_phospholipids serum_phospholipids 2.43E-05 0.558 no up up no no no 18:1/16:0-PC+blood 16:0/22:6-PC+blood 0.615037594 0 0.744273504 serum_phospholipids serum_phospholipids 2.43E-05 4.53E-05 no up up no up up 18:1/16:0-PC+blood 16:1/16:0-PC+blood 0.813533835 0.637254902 0.80991453 serum_phospholipids serum_phospholipids 2.43E-05 0.0215 no up up no up up 18:1/16:0-PC+blood 16:1/16:1-PC+blood 0.590977444 0 0.556923077 serum_phospholipids serum_phospholipids 2.43E-05 0.0177 no up up no no up 18:1/16:0-PC+blood 16:1/18:2-PG+blood 0.595488722 0 0 serum_phospholipids serum_phospholipids 2.43E-05 1.40E-08 no up up no up up 18:1/16:0-PC+blood 18:0-LPC+blood 0 -0.649509804 0 serum_phospholipids serum_phospholipids 2.43E-05 0.554 no up up no no no 18:1/16:0-PC+blood 18:0-LPE+blood 0 -0.485294118 0 serum_phospholipids serum_phospholipids 2.43E-05 0.491 no up up no no no 18:1/16:0-PC+blood 18:0/16:0-PC+blood 0.843609023 0.904411765 0.703931624 serum_phospholipids serum_phospholipids 2.43E-05 9.64E-07 no up up up up up 18:1/16:0-PC+blood 18:0/18:0-PE+blood -0.652631579 0 -0.489230769 serum_phospholipids serum_phospholipids 2.43E-05 0.00896 no up up up up no 18:1/16:0-PC+blood 18:0/18:1-PE+blood -0.628571429 0 -0.460512821 serum_phospholipids serum_phospholipids 2.43E-05 0.00716 no up up up up no 18:1/16:0-PC+blood 18:0/18:1-PG+blood 0 0 -0.474188034 serum_phospholipids serum_phospholipids 2.43E-05 0.000842 no up up no up no 18:1/16:0-PC+blood 18:0/18:2-PC+blood 0.878195489 0.789215686 0.824957265 serum_phospholipids serum_phospholipids 2.43E-05 1.74E-06 no up up no up up 18:1/16:0-PC+blood 18:0/20:4-PC+blood 0.598496241 0 0.468717949 serum_phospholipids serum_phospholipids 2.43E-05 0.454 no up up no no no 18:1/16:0-PC+blood 18:0/20:5-PC+blood 0.533834586 0 0.511794872 serum_phospholipids serum_phospholipids 2.43E-05 0.17 no up up no no no 18:1/16:0-PC+blood 18:0/22:6-PC+blood 0 0 0.569230769 serum_phospholipids serum_phospholipids 2.43E-05 0.0775 no up up no no up 18:1/16:0-PC+blood 18:1-LPE+blood -0.506766917 0 0 serum_phospholipids serum_phospholipids 2.43E-05 0.117 no up up no no no 18:1/16:0-PC+blood Adrenergic signaling in cardiomyocytes 0 -0.597058824 0 serum_phospholipids kegg 2.43E-05 NA no up up no no up 18:1/16:0-PC+blood Aldosterone synthesis and secretion 0 0 -0.433846154 serum_phospholipids kegg 2.43E-05 NA no up up no up up 18:1/16:0-PC+blood Alistipes 0.495097865 -0.486817995 0 serum_phospholipids Genus 2.43E-05 0.0114 no up up no up no 18:1/16:0-PC+blood Alzheimer disease 0 0 -0.514615385 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood AMPK signaling pathway 0 -0.611764706 0 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Amyotrophic lateral sclerosis 0 0 -0.577692308 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Blautia 0 0 -0.407206513 acetate-producing serum_phospholipids Genus 2.43E-05 1.36E-05 no up up up dn dn 18:1/16:0-PC+blood CA+stool -0.582417582 0 0 serum_phospholipids stool_bileacids 2.43E-05 0.827 no up up no no no 18:1/16:0-PC+blood Calcium signaling pathway 0 0 -0.415384615 serum_phospholipids kegg 2.43E-05 NA no up up no up up 18:1/16:0-PC+blood Cardiac muscle contraction 0 0 -0.546153846 serum_phospholipids kegg 2.43E-05 NA no up up no no up 18:1/16:0-PC+blood Cell cycle 0 -0.5 0 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Central carbon metabolism in cancer 0 -0.738235294 0 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Chemokine signaling pathway 0 0.523529412 0 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Diabetic cardiomyopathy 0 0 -0.49 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Dilated cardiomyopathy 0 0 -0.475384615 serum_phospholipids kegg 2.43E-05 NA no up up no up up 18:1/16:0-PC+blood EGFR tyrosine kinase inhibitor resistance 0 -0.570588235 0 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Endocrine and other factor-regulated calcium reabsorption 0 0 -0.433076923 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Fusobacterium 0 -0.556542163 0 serum_phospholipids Genus 2.43E-05 0.628 no up up no no no 18:1/16:0-PC+blood Gap junction 0 0 -0.476153846 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Gastric acid secretion 0 0 -0.418461538 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood GCDCA+stool 0 0.609090909 0 yes serum_phospholipids stool_bileacids 2.43E-05 0.0471 no up up no dn no 18:1/16:0-PC+blood GDCA+stool -0.681318681 0 0 serum_phospholipids stool_bileacids 2.43E-05 0.656 no up up no no no 18:1/16:0-PC+blood Glucagon signaling pathway 0 -0.505882353 0 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Hippo signaling pathway 0 0 -0.441538462 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Huntington disease 0 0 -0.496153846 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood IL-17 signaling pathway 0 0 0.504615385 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Inflammatory mediator regulation of TRP channels 0 -0.555882353 -0.469230769 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Insulin signaling pathway 0 -0.502941176 0 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Lachnospira 0 0 0.414726635 butyrate-producing serum_phospholipids Genus 2.43E-05 0.279 no up up no no no 18:1/16:0-PC+blood LCA+stool 0.56043956 0 0 serum_phospholipids stool_bileacids 2.43E-05 0.314 no up up no no no 18:1/16:0-PC+blood Lysosome 0 0 0.427692308 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood mRNA surveillance pathway 0 -0.535294118 0 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood mTOR signaling pathway 0 -0.591176471 0 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Non-alcoholic fatty liver disease 0 0 -0.594615385 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Oxidative phosphorylation 0 0 -0.476153846 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Pancreatic secretion 0 0 -0.487692308 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Peroxisome 0 0 0.440769231 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Phenylacetic acid+stool 0 -0.627272727 0 serum_phospholipids stool_cometabolism 2.43E-05 0.785 no up up no no no 18:1/16:0-PC+blood Prion disease 0 0 -0.498461538 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Proteasome 0 0 0.526153846 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Renal cell carcinoma 0 -0.526470588 0 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Retrograde endocannabinoid signaling 0 0 -0.407692308 serum_phospholipids kegg 2.43E-05 NA no up up no no up 18:1/16:0-PC+blood RNA transport 0 -0.576470588 0 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Ruminococcus 0 0 -0.428494654 serum_phospholipids Genus 2.43E-05 0.0679 no up up no no dn 18:1/16:0-PC+blood TCA+stool -0.594223396 0 0 serum_phospholipids stool_bileacids 2.43E-05 0.458 no up up no no no 18:1/16:0-PC+blood Th1 and Th2 cell differentiation 0 0.502941176 0 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Thermogenesis 0 0 -0.423076923 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Thyroid hormone signaling pathway 0 0 -0.493076923 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Toxoplasmosis 0 0.511764706 0 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Vasopressin-regulated water reabsorption 0 0 -0.477692308 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PC+blood Yersinia infection 0 0.517647059 0 serum_phospholipids kegg 2.43E-05 NA no up up no no no 18:1/16:0-PE+blood 11-HETE+blood 0 0.610859581 0 serum_phospholipids serum_ARA 0.000182 0.464 up up no no no no 18:1/16:0-PE+blood 12-ketoDCA+blood 0 -0.573013623 0 serum_phospholipids serum_bileacids 0.000182 0.517 up up no no no no 18:1/16:0-PE+blood "12,13-EPOME+blood" 0 0.506070205 0 serum_phospholipids serum_ARA 0.000182 0.901 up up no no no no 18:1/16:0-PE+blood 13-HODE+blood -0.487218045 0 0 serum_phospholipids serum_ARA 0.000182 0.32 up up no no no no 18:1/16:0-PE+blood 14:0/18:0-PC+blood 0 0.612745098 0 serum_phospholipids serum_phospholipids 0.000182 0.00289 up up no up up no 18:1/16:0-PE+blood 14:0/20:4-PC+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.000182 0.486 up up no no no no 18:1/16:0-PE+blood 16:0-LPE+blood 0.682706767 0 0 serum_phospholipids serum_phospholipids 0.000182 0.0711 up up no up up no 18:1/16:0-PE+blood 16:0/16:0-PI+blood 0.559398496 0.558823529 0.442051282 serum_phospholipids serum_phospholipids 0.000182 0.358 up up no no no no 18:1/16:0-PE+blood 16:0/16:1-PC+blood 0 0.612745098 0 serum_phospholipids serum_phospholipids 0.000182 0.00283 up up no up up no 18:1/16:0-PE+blood 16:0/16:1-PI+blood 0.493233083 0.541666667 0.442051282 serum_phospholipids serum_phospholipids 0.000182 0.262 up up no no no no 18:1/16:0-PE+blood 16:0/18:0-PS+blood 0.580451128 0 0.437264957 serum_phospholipids serum_phospholipids 0.000182 0.377 up up no no no no 18:1/16:0-PE+blood 16:0/18:1-PC+blood -0.494736842 0 0 serum_phospholipids serum_phospholipids 0.000182 6.15E-07 up up no up up up 18:1/16:0-PE+blood 16:0/18:1-PE+blood 0.85112782 0.926470588 0.80991453 serum_phospholipids serum_phospholipids 0.000182 0.000107 up up no up up no 18:1/16:0-PE+blood 16:0/18:2-PC+blood -0.684210526 0 0 serum_phospholipids serum_phospholipids 0.000182 3.24E-06 up up no no up up 18:1/16:0-PE+blood 16:0/18:2-PI+blood 0 0.723039216 0 serum_phospholipids serum_phospholipids 0.000182 0.269 up up no no no no 18:1/16:0-PE+blood 16:0/20:3-PC+blood -0.739849624 0 0 serum_phospholipids serum_phospholipids 0.000182 5.43E-06 up up no no up up 18:1/16:0-PE+blood 16:0/20:4-PC+blood 0 -0.607843137 0 serum_phospholipids serum_phospholipids 0.000182 0.0262 up up no no up no 18:1/16:0-PE+blood 16:0/20:4-PE+blood 0.739849624 0.786764706 0.705982906 serum_phospholipids serum_phospholipids 0.000182 0.00139 up up no up up no 18:1/16:0-PE+blood 16:0/22:6-PC+blood -0.542857143 -0.575980392 0 serum_phospholipids serum_phospholipids 0.000182 4.53E-05 up up no no up up 18:1/16:0-PE+blood 16:0/22:6-PE+blood 0.666165414 0.482843137 0.76957265 serum_phospholipids serum_phospholipids 0.000182 0.000934 up up no up up no 18:1/16:0-PE+blood 16:1/16:0-PC+blood -0.514285714 0 0 serum_phospholipids serum_phospholipids 0.000182 0.0215 up up no no up up 18:1/16:0-PE+blood 16:1/18:1-PG+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 0.000182 3.21E-05 up up no no up up 18:1/16:0-PE+blood 16:1/18:2-PG+blood -0.560902256 0 0 serum_phospholipids serum_phospholipids 0.000182 1.40E-08 up up no no up up 18:1/16:0-PE+blood 16:1+blood 0 0.492647059 0 yes serum_phospholipids serum_fattyacid 0.000182 0.0186 up up no no no dn 18:1/16:0-PE+blood 18:0-LPE+blood 0.57593985 0 0.447521368 serum_phospholipids serum_phospholipids 0.000182 0.491 up up no no no no 18:1/16:0-PE+blood 18:0/16:0-PC+blood -0.460150376 0 0 serum_phospholipids serum_phospholipids 0.000182 9.64E-07 up up no up up up 18:1/16:0-PE+blood 18:0/18:0-PE+blood 0.803007519 0.654411765 0.658119658 serum_phospholipids serum_phospholipids 0.000182 0.00896 up up no up up no 18:1/16:0-PE+blood 18:0/18:0-PS+blood 0 0 0.48991453 serum_phospholipids serum_phospholipids 0.000182 0.00617 up up no no up no 18:1/16:0-PE+blood 18:0/18:1-PE+blood 0.827067669 0.740196078 0.738803419 serum_phospholipids serum_phospholipids 0.000182 0.00716 up up no up up no 18:1/16:0-PE+blood 18:0/18:1-PG+blood 0.556390977 0 0.503589744 serum_phospholipids serum_phospholipids 0.000182 0.000842 up up no no up no 18:1/16:0-PE+blood 18:0/18:1-PI+blood 0 0.578431373 0 serum_phospholipids serum_phospholipids 0.000182 0.599 up up no no no no 18:1/16:0-PE+blood 18:0/18:2-PC+blood -0.646616541 0 0 serum_phospholipids serum_phospholipids 0.000182 1.74E-06 up up no no up up 18:1/16:0-PE+blood 18:0/20:2-PC+blood 0 0 -0.417435897 serum_phospholipids serum_phospholipids 0.000182 0.733 up up no no no no 18:1/16:0-PE+blood 18:0/20:4-PC+blood 0 -0.647058824 0 serum_phospholipids serum_phospholipids 0.000182 0.454 up up no no no no 18:1/16:0-PE+blood 18:0/20:5-PC+blood -0.529323308 -0.644607843 0 serum_phospholipids serum_phospholipids 0.000182 0.17 up up no no no no 18:1/16:0-PE+blood 18:0/22:6-PE+blood 0.545864662 0 0.605470085 serum_phospholipids serum_phospholipids 0.000182 0.00022 up up no up up no 18:1/16:0-PE+blood 18:1/16:0-PC+blood -0.670676692 0 0 serum_phospholipids serum_phospholipids 0.000182 2.43E-05 up up no no up up 18:1/16:0-PI+blood 11-HETE+blood 0 0.487540511 0 serum_phospholipids serum_ARA 0.793 0.464 no no no no no no 18:1/16:0-PI+blood 14:0-LPC+blood 0 0 0.562393162 serum_phospholipids serum_phospholipids 0.793 0.00689 no no no up up no 18:1/16:0-PI+blood 14:0/16:0-PC+blood 0 0 0.550769231 serum_phospholipids serum_phospholipids 0.793 0.0358 no no no no up no 18:1/16:0-PI+blood 14:0/18:0-PC+blood 0 0.62254902 0.411282051 serum_phospholipids serum_phospholipids 0.793 0.00289 no no no up up no 18:1/16:0-PI+blood 15-HETE+blood -0.475771229 0 0 serum_phospholipids serum_ARA 0.793 0.819 no no no no no no 18:1/16:0-PI+blood 16:0-LPC+blood 0 0 0.578119658 serum_phospholipids serum_phospholipids 0.793 0.00456 no no no up up no 18:1/16:0-PI+blood 16:0/16:0-PI+blood 0.712781955 0.732843137 0.595213675 serum_phospholipids serum_phospholipids 0.793 0.358 no no no no no no 18:1/16:0-PI+blood 16:0/16:1-PC+blood 0 0.62745098 0 serum_phospholipids serum_phospholipids 0.793 0.00283 no no no up up no 18:1/16:0-PI+blood 16:0/16:1-PI+blood 0.508270677 0.762254902 0.634188034 serum_phospholipids serum_phospholipids 0.793 0.262 no no no no no no 18:1/16:0-PI+blood 16:0/18:1-PE+blood 0.57443609 0.590686275 0 serum_phospholipids serum_phospholipids 0.793 0.000107 no no no up up no 18:1/16:0-PI+blood 16:0/18:2-PI+blood 0.568421053 0.617647059 0.660854701 serum_phospholipids serum_phospholipids 0.793 0.269 no no no no no no 18:1/16:0-PI+blood 16:0/20:3-PC+blood -0.57593985 0 0 serum_phospholipids serum_phospholipids 0.793 5.43E-06 no no no no up up 18:1/16:0-PI+blood 16:0/20:4-PC+blood 0 -0.764705882 0 serum_phospholipids serum_phospholipids 0.793 0.0262 no no no no up no 18:1/16:0-PI+blood 16:0/20:4-PE+blood 0.454135338 0 0 serum_phospholipids serum_phospholipids 0.793 0.00139 no no no up up no 18:1/16:0-PI+blood 16:0/20:4-PI+blood 0.678195489 0.625 0.545982906 serum_phospholipids serum_phospholipids 0.793 0.558 no no no no no no 18:1/16:0-PI+blood 16:0/22:6-PC+blood 0 -0.710784314 0 serum_phospholipids serum_phospholipids 0.793 4.53E-05 no no no no up up 18:1/16:0-PI+blood 16:1-LPC+blood 0 0 0.628717949 serum_phospholipids serum_phospholipids 0.793 0.0241 no no no no up no 18:1/16:0-PI+blood 16:1/16:0-PC+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.793 0.0215 no no no no up up 18:1/16:0-PI+blood 16:1/18:1-PG+blood 0 0.693627451 0 serum_phospholipids serum_phospholipids 0.793 3.21E-05 no no no no up up 18:1/16:0-PI+blood 16:1/18:2-PG+blood -0.466165414 0 0 serum_phospholipids serum_phospholipids 0.793 1.40E-08 no no no no up up 18:1/16:0-PI+blood 18:0-LPA+blood 0 0 0.524786325 serum_phospholipids serum_phospholipids 0.793 0.0725 no no no no dn no 18:1/16:0-PI+blood 18:0-LPC+blood 0.562406015 0 0 serum_phospholipids serum_phospholipids 0.793 0.554 no no no no no no 18:1/16:0-PI+blood 18:0-LPE+blood 0.542857143 0 0 serum_phospholipids serum_phospholipids 0.793 0.491 no no no no no no 18:1/16:0-PI+blood 18:0/18:0-PE+blood 0.596992481 0.678921569 0 serum_phospholipids serum_phospholipids 0.793 0.00896 no no no up up no 18:1/16:0-PI+blood 18:0/18:1-PE+blood 0.642105263 0.654411765 0 serum_phospholipids serum_phospholipids 0.793 0.00716 no no no up up no 18:1/16:0-PI+blood 18:0/18:1-PG+blood 0.518796992 0 0 serum_phospholipids serum_phospholipids 0.793 0.000842 no no no no up no 18:1/16:0-PI+blood 18:0/18:1-PI+blood 0.730827068 0.845588235 0.764786325 serum_phospholipids serum_phospholipids 0.793 0.599 no no no no no no 18:1/16:0-PI+blood 18:0/18:2-PC+blood -0.497744361 0 0 serum_phospholipids serum_phospholipids 0.793 1.74E-06 no no no no up up 18:1/16:0-PI+blood 18:0/18:2-PI+blood 0 0 0.664273504 serum_phospholipids serum_phospholipids 0.793 0.179 no no no no no no 18:1/16:0-PI+blood 18:0/20:3-PI+blood 0 0.536764706 0 serum_phospholipids serum_phospholipids 0.793 0.377 no no no no no no 18:1/16:0-PI+blood 18:0/20:4-PC+blood 0 -0.727941176 0 serum_phospholipids serum_phospholipids 0.793 0.454 no no no no no no 18:1/16:0-PI+blood 18:0/20:5-PC+blood -0.62406015 -0.75245098 -0.499487179 serum_phospholipids serum_phospholipids 0.793 0.17 no no no no no no 18:1/16:0-PI+blood 18:0/22:6-PI+blood 0 0 0.552820513 serum_phospholipids serum_phospholipids 0.793 0.425 no no no no no no 18:1/16:0-PI+blood 18:1/16:0-PE+blood 0.554887218 0.676470588 0 serum_phospholipids serum_phospholipids 0.793 0.000182 no no no up up no 18:1/16:1-PE+blood 11-HETE+blood 0 0.694028256 0 serum_phospholipids serum_ARA 0.000184 0.464 up up no no no no 18:1/16:1-PE+blood 12-ketoDCA+blood 0 -0.536788624 0 serum_phospholipids serum_bileacids 0.000184 0.517 up up no no no no 18:1/16:1-PE+blood "12,13-EPOME+blood" 0 0.51233345 0 serum_phospholipids serum_ARA 0.000184 0.901 up up no no no no 18:1/16:1-PE+blood 13-HODE+blood -0.448120301 0 0 serum_phospholipids serum_ARA 0.000184 0.32 up up no no no no 18:1/16:1-PE+blood 14:0/18:0-PC+blood 0 0.762254902 0.42974359 serum_phospholipids serum_phospholipids 0.000184 0.00289 up up no up up no 18:1/16:1-PE+blood 14:0/20:4-PC+blood 0 -0.517156863 0 serum_phospholipids serum_phospholipids 0.000184 0.486 up up no no no no 18:1/16:1-PE+blood 15-HETE+blood -0.516681494 0 0 serum_phospholipids serum_ARA 0.000184 0.819 up up no no no no 18:1/16:1-PE+blood 16:0-LPE+blood 0.696240602 0 0.561709402 serum_phospholipids serum_phospholipids 0.000184 0.0711 up up no up up no 18:1/16:1-PE+blood 16:0/16:0-PI+blood 0.726315789 0.578431373 0 serum_phospholipids serum_phospholipids 0.000184 0.358 up up no no no no 18:1/16:1-PE+blood 16:0/16:1-PC+blood 0 0.762254902 0.44 serum_phospholipids serum_phospholipids 0.000184 0.00283 up up no up up no 18:1/16:1-PE+blood 16:0/16:1-PI+blood 0.560902256 0.605392157 0.511111111 serum_phospholipids serum_phospholipids 0.000184 0.262 up up no no no no 18:1/16:1-PE+blood 16:0/18:0-PC+blood 0 0 -0.51042735 serum_phospholipids serum_phospholipids 0.000184 0.521 up up no no no no 18:1/16:1-PE+blood 16:0/18:0-PS+blood 0.630075188 0 0.422222222 serum_phospholipids serum_phospholipids 0.000184 0.377 up up no no no no 18:1/16:1-PE+blood 16:0/18:1-PC+blood -0.523308271 0 0 serum_phospholipids serum_phospholipids 0.000184 6.15E-07 up up no up up up 18:1/16:1-PE+blood 16:0/18:1-PE+blood 0.954887218 0.990196078 0.95965812 serum_phospholipids serum_phospholipids 0.000184 0.000107 up up no up up no 18:1/16:1-PE+blood 16:0/18:2-PC+blood -0.589473684 0 0 serum_phospholipids serum_phospholipids 0.000184 3.24E-06 up up no no up up 18:1/16:1-PE+blood 16:0/18:2-PI+blood 0.569924812 0.791666667 0 serum_phospholipids serum_phospholipids 0.000184 0.269 up up no no no no 18:1/16:1-PE+blood 16:0/20:3-PC+blood -0.673684211 0 0 serum_phospholipids serum_phospholipids 0.000184 5.43E-06 up up no no up up 18:1/16:1-PE+blood 16:0/20:4-PC+blood -0.637593985 -0.588235294 0 serum_phospholipids serum_phospholipids 0.000184 0.0262 up up no no up no 18:1/16:1-PE+blood 16:0/20:4-PE+blood 0.812030075 0.81372549 0.904273504 serum_phospholipids serum_phospholipids 0.000184 0.00139 up up no up up no 18:1/16:1-PE+blood 16:0/20:4-PI+blood 0.445112782 0 0.491965812 serum_phospholipids serum_phospholipids 0.000184 0.558 up up no no no no 18:1/16:1-PE+blood 16:0/22:6-PC+blood 0 -0.529411765 0 serum_phospholipids serum_phospholipids 0.000184 4.53E-05 up up no no up up 18:1/16:1-PE+blood 16:0/22:6-PE+blood 0.708270677 0.507352941 0.866666667 serum_phospholipids serum_phospholipids 0.000184 0.000934 up up no up up no 18:1/16:1-PE+blood 16:1/18:1-PG+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 0.000184 3.21E-05 up up no no up up 18:1/16:1-PE+blood 16:1/18:2-PG+blood -0.460150376 0 0 serum_phospholipids serum_phospholipids 0.000184 1.40E-08 up up no no up up 18:1/16:1-PE+blood 16:1+blood 0 0 0.571965812 yes serum_phospholipids serum_fattyacid 0.000184 0.0186 up up no no no dn 18:1/16:1-PE+blood 18:0-LPE+blood 0.62556391 0 0 serum_phospholipids serum_phospholipids 0.000184 0.491 up up no no no no 18:1/16:1-PE+blood 18:0/16:0-PC+blood -0.482706767 0 0 serum_phospholipids serum_phospholipids 0.000184 9.64E-07 up up no up up up 18:1/16:1-PE+blood 18:0/18:0-PE+blood 0.714285714 0.522058824 0 serum_phospholipids serum_phospholipids 0.000184 0.00896 up up no up up no 18:1/16:1-PE+blood 18:0/18:0-PS+blood 0.458646617 0 0.477606838 serum_phospholipids serum_phospholipids 0.000184 0.00617 up up no no up no 18:1/16:1-PE+blood 18:0/18:1-PE+blood 0.751879699 0.632352941 0 serum_phospholipids serum_phospholipids 0.000184 0.00716 up up no up up no 18:1/16:1-PE+blood 18:0/18:1-PG+blood 0.630075188 0 0 serum_phospholipids serum_phospholipids 0.000184 0.000842 up up no no up no 18:1/16:1-PE+blood 18:0/18:1-PI+blood 0 0.504901961 0 serum_phospholipids serum_phospholipids 0.000184 0.599 up up no no no no 18:1/16:1-PE+blood 18:0/18:2-PC+blood -0.55037594 0 0 serum_phospholipids serum_phospholipids 0.000184 1.74E-06 up up no no up up 18:1/16:1-PE+blood 18:0/20:2-PC+blood 0 0 -0.541196581 serum_phospholipids serum_phospholipids 0.000184 0.733 up up no no no no 18:1/16:1-PE+blood 18:0/20:3-PI+blood 0 0.595588235 0 serum_phospholipids serum_phospholipids 0.000184 0.377 up up no no no no 18:1/16:1-PE+blood 18:0/20:4-PC+blood -0.663157895 -0.666666667 0 serum_phospholipids serum_phospholipids 0.000184 0.454 up up no no no no 18:1/16:1-PE+blood 18:0/20:5-PC+blood -0.551879699 -0.691176471 0 serum_phospholipids serum_phospholipids 0.000184 0.17 up up no no no no 18:1/16:1-PE+blood 18:0/22:6-PE+blood 0.652631579 0 0.690940171 serum_phospholipids serum_phospholipids 0.000184 0.00022 up up no up up no 18:1/16:1-PE+blood 18:1-LPC+blood 0 -0.568627451 0 serum_phospholipids serum_phospholipids 0.000184 0.179 up up no no no no 18:1/16:1-PE+blood 18:1/16:0-PC+blood -0.589473684 0 0 serum_phospholipids serum_phospholipids 0.000184 2.43E-05 up up no no up up 18:1/16:1-PE+blood 18:1/16:0-PE+blood 0.869172932 0.911764706 0.76 serum_phospholipids serum_phospholipids 0.000184 0.000182 up up no up up no 18:1/16:1-PE+blood 18:1/16:0-PI+blood 0.554887218 0.593137255 0 serum_phospholipids serum_phospholipids 0.000184 0.793 up up no no no no 18:1/18:0-PC+blood 14:1/18:2-PG+blood 0 0 -0.407179487 serum_phospholipids serum_phospholipids 1.83E-06 0.00259 no up up no up up 18:1/18:0-PC+blood 16:0-LPE+blood -0.527819549 0 0 serum_phospholipids serum_phospholipids 1.83E-06 0.0711 no up up up up no 18:1/18:0-PC+blood 16:0/14:0-PC+blood 0.607518797 0.848039216 0.822905983 serum_phospholipids serum_phospholipids 1.83E-06 0.0206 no up up no up up 18:1/18:0-PC+blood 16:0/16:0-PC+blood 0.693233083 0.585784314 0.660854701 serum_phospholipids serum_phospholipids 1.83E-06 0.00079 no up up no up up 18:1/18:0-PC+blood 16:0/16:0-PI+blood -0.595488722 0 0 serum_phospholipids serum_phospholipids 1.83E-06 0.358 no up up no no no 18:1/18:0-PC+blood 16:0/16:1-PI+blood -0.633082707 0 0 serum_phospholipids serum_phospholipids 1.83E-06 0.262 no up up no no no 18:1/18:0-PC+blood 16:0/18:0-PC+blood 0.446616541 0 0.541880342 serum_phospholipids serum_phospholipids 1.83E-06 0.521 no up up no no no 18:1/18:0-PC+blood 16:0/18:0-PS+blood 0 0 -0.50017094 serum_phospholipids serum_phospholipids 1.83E-06 0.377 no up up no no no 18:1/18:0-PC+blood 16:0/18:1-PC+blood 0.780451128 0.830882353 0.579487179 serum_phospholipids serum_phospholipids 1.83E-06 6.15E-07 no up up up up up 18:1/18:0-PC+blood 16:0/18:1-PE+blood -0.630075188 0 0 serum_phospholipids serum_phospholipids 1.83E-06 0.000107 no up up up up no 18:1/18:0-PC+blood 16:0/18:2-PC+blood 0.885714286 0.799019608 0.833162393 serum_phospholipids serum_phospholipids 1.83E-06 3.24E-06 no up up no up up 18:1/18:0-PC+blood 16:0/18:2-PI+blood -0.445112782 0 0 serum_phospholipids serum_phospholipids 1.83E-06 0.269 no up up no no no 18:1/18:0-PC+blood 16:0/20:3-PC+blood 0.793984962 0.68627451 0.477606838 serum_phospholipids serum_phospholipids 1.83E-06 5.43E-06 no up up no up up 18:1/18:0-PC+blood 16:0/20:4-PC+blood 0.536842105 0 0.571282051 serum_phospholipids serum_phospholipids 1.83E-06 0.0262 no up up no up no 18:1/18:0-PC+blood 16:0/20:4-PI+blood -0.580451128 -0.504901961 0 serum_phospholipids serum_phospholipids 1.83E-06 0.558 no up up no no no 18:1/18:0-PC+blood 16:0/22:0-PE+blood 0 0 0.463931624 serum_phospholipids serum_phospholipids 1.83E-06 0.00839 no up up dn no up 18:1/18:0-PC+blood 16:0/22:6-PC+blood 0.633082707 0 0.745641026 serum_phospholipids serum_phospholipids 1.83E-06 4.53E-05 no up up no up up 18:1/18:0-PC+blood 16:1-LPC+blood 0 -0.529411765 0 serum_phospholipids serum_phospholipids 1.83E-06 0.0241 no up up no up no 18:1/18:0-PC+blood 16:1/16:0-PC+blood 0.751879699 0 0.71008547 serum_phospholipids serum_phospholipids 1.83E-06 0.0215 no up up no up up 18:1/18:0-PC+blood 16:1/16:1-PC+blood 0.62406015 0 0.543931624 serum_phospholipids serum_phospholipids 1.83E-06 0.0177 no up up no no up 18:1/18:0-PC+blood 16:1/18:2-PG+blood 0.62556391 0 0 serum_phospholipids serum_phospholipids 1.83E-06 1.40E-08 no up up no up up 18:1/18:0-PC+blood 18:0-LPC+blood 0 -0.536764706 0 serum_phospholipids serum_phospholipids 1.83E-06 0.554 no up up no no no 18:1/18:0-PC+blood 18:0-LPE+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 1.83E-06 0.491 no up up no no no 18:1/18:0-PC+blood 18:0/16:0-PC+blood 0.732330827 0.779411765 0.553504274 serum_phospholipids serum_phospholipids 1.83E-06 9.64E-07 no up up up up up 18:1/18:0-PC+blood 18:0/18:0-PE+blood -0.57443609 0 0 serum_phospholipids serum_phospholipids 1.83E-06 0.00896 no up up up up no 18:1/18:0-PC+blood 18:0/18:0-PS+blood 0 0 -0.476239316 serum_phospholipids serum_phospholipids 1.83E-06 0.00617 no up up no up no 18:1/18:0-PC+blood 18:0/18:1-PE+blood -0.581954887 0 -0.448205128 serum_phospholipids serum_phospholipids 1.83E-06 0.00716 no up up up up no 18:1/18:0-PC+blood 18:0/18:1-PG+blood 0 0 -0.595213675 serum_phospholipids serum_phospholipids 1.83E-06 0.000842 no up up no up no 18:1/18:0-PC+blood 18:0/18:2-PC+blood 0.980451128 0.99754902 0.993846154 serum_phospholipids serum_phospholipids 1.83E-06 1.74E-06 no up up no up up 18:1/18:0-PC+blood 18:0/20:4-PC+blood 0.523308271 0 0.532991453 serum_phospholipids serum_phospholipids 1.83E-06 0.454 no up up no no no 18:1/18:0-PC+blood 18:0/20:5-PC+blood 0.57443609 0 0.572649573 serum_phospholipids serum_phospholipids 1.83E-06 0.17 no up up no no no 18:1/18:0-PC+blood 18:0/22:6-PC+blood 0.457142857 0 0.517948718 serum_phospholipids serum_phospholipids 1.83E-06 0.0775 no up up no no up 18:1/18:0-PC+blood 18:0+blood 0 0 0.488547009 serum_phospholipids serum_fattyacid 1.83E-06 0.344 no up up no no no 18:1/18:0-PC+blood 18:1/16:0-PC+blood 0.876691729 0.794117647 0.827008547 serum_phospholipids serum_phospholipids 1.83E-06 2.43E-05 no up up no up up 18:1/18:0-PC+blood 18:1/16:0-PE+blood -0.643609023 0 -0.410598291 serum_phospholipids serum_phospholipids 1.83E-06 0.000182 no up up up up no 18:1/18:0-PC+blood 18:1/16:0-PI+blood -0.529323308 0 0 serum_phospholipids serum_phospholipids 1.83E-06 0.793 no up up no no no 18:1/18:0-PC+blood 18:1/16:1-PE+blood -0.578947368 0 0 serum_phospholipids serum_phospholipids 1.83E-06 0.000184 no up up up up no 18:1/18:0-PC+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.529323308 serum_phospholipids stool_cometabolism 1.83E-06 0.33 no up up no no no 18:1/18:0-PC+blood Adherens junction 0 0 -0.409230769 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood Alzheimer disease 0 0 -0.504615385 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood Amyotrophic lateral sclerosis 0 0 -0.510769231 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.410769231 serum_phospholipids kegg 1.83E-06 NA no up up no up up 18:1/18:0-PC+blood Butyricicoccus 0 0 -0.421448237 butyrate-producing serum_phospholipids Genus 1.83E-06 0.852 no up up no no no 18:1/18:0-PC+blood Cardiac muscle contraction 0 0 -0.561538462 serum_phospholipids kegg 1.83E-06 NA no up up no no up 18:1/18:0-PC+blood Central carbon metabolism in cancer 0 -0.555882353 0 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood DCA+stool 0 0 -0.514285714 serum_phospholipids stool_bileacids 1.83E-06 0.195 no up up no no no 18:1/18:0-PC+blood Diabetic cardiomyopathy 0 0 -0.515384615 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood Dilated cardiomyopathy 0 0 -0.414615385 serum_phospholipids kegg 1.83E-06 NA no up up no up up 18:1/18:0-PC+blood Focal adhesion 0 0 -0.43 serum_phospholipids kegg 1.83E-06 NA no up up no up up 18:1/18:0-PC+blood Fusobacterium 0 -0.647778583 0 serum_phospholipids Genus 1.83E-06 0.628 no up up no no no 18:1/18:0-PC+blood Gap junction 0.48245614 0 0 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood GCDCA+stool 0 0.609090909 0 yes serum_phospholipids stool_bileacids 1.83E-06 0.0471 no up up no dn no 18:1/18:0-PC+blood Glutamatergic synapse 0.464912281 0 0 serum_phospholipids kegg 1.83E-06 NA no up up no up up 18:1/18:0-PC+blood Hippo signaling pathway 0 0 -0.449230769 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood Huntington disease 0 0 -0.463846154 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood Intestinal immune network for IgA production 0.492982456 0 0 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood L-Tyrosine+stool 0 0 0.45112782 serum_phospholipids stool_cometabolism 1.83E-06 0.44 no up up no no no 18:1/18:0-PC+blood Lachnospira 0 0 0.44178147 butyrate-producing serum_phospholipids Genus 1.83E-06 0.279 no up up no no no 18:1/18:0-PC+blood mTOR signaling pathway 0 0 0.483846154 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood Non-alcoholic fatty liver disease 0 0 -0.456153846 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood Oxidative phosphorylation 0 0 -0.481538462 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood Phenylacetic acid+stool 0 -0.763636364 0 serum_phospholipids stool_cometabolism 1.83E-06 0.785 no up up no no no 18:1/18:0-PC+blood Prion disease 0 0 -0.553846154 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood Propionic acid+stool 0 0 -0.502255639 yes serum_phospholipids stool_scfa 1.83E-06 0.0436 no up up dn no up 18:1/18:0-PC+blood Retrograde endocannabinoid signaling 0 0 -0.405384615 serum_phospholipids kegg 1.83E-06 NA no up up no no up 18:1/18:0-PC+blood Salivary secretion 0.573684211 0 0 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood TCA+stool -0.566713053 0 0 serum_phospholipids stool_bileacids 1.83E-06 0.458 no up up no no no 18:1/18:0-PC+blood Thyroid hormone signaling pathway 0 0 -0.526923077 serum_phospholipids kegg 1.83E-06 NA no up up no no no 18:1/18:0-PC+blood total_stool_scfa+stool 0 0 -0.467669173 serum_phospholipids stool_scfa 1.83E-06 0.0534 no up up dn no up 18:1/18:0-PE+blood 11-HETE+blood 0 0.501879937 0 serum_phospholipids serum_ARA 1.39E-06 0.464 up up no no no no 18:1/18:0-PE+blood 12-ketoDCA+blood 0 -0.559840896 0 serum_phospholipids serum_bileacids 1.39E-06 0.517 up up no no no no 18:1/18:0-PE+blood "12,13-EPOME+blood" 0 0.541144378 0 serum_phospholipids serum_ARA 1.39E-06 0.901 up up no no no no 18:1/18:0-PE+blood 13-HODE+blood -0.481203008 0 0 serum_phospholipids serum_ARA 1.39E-06 0.32 up up no no no no 18:1/18:0-PE+blood 14:0-LPC+blood 0 0.49754902 0 serum_phospholipids serum_phospholipids 1.39E-06 0.00689 up up no up up no 18:1/18:0-PE+blood 14:0/18:0-PC+blood 0 0.629901961 0 serum_phospholipids serum_phospholipids 1.39E-06 0.00289 up up no up up no 18:1/18:0-PE+blood 14:0+blood 0 0.490196078 0 yes serum_phospholipids serum_fattyacid 1.39E-06 0.00572 up up no up no dn 18:1/18:0-PE+blood 14:1/18:2-PG+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 1.39E-06 0.00259 up up no no up up 18:1/18:0-PE+blood 16:0-LPE+blood 0.621052632 0 0 serum_phospholipids serum_phospholipids 1.39E-06 0.0711 up up no up up no 18:1/18:0-PE+blood 16:0/14:0-PC+blood 0 0 -0.451623932 serum_phospholipids serum_phospholipids 1.39E-06 0.0206 up up no no up up 18:1/18:0-PE+blood 16:0/16:0-PI+blood 0.52481203 0.573529412 0 serum_phospholipids serum_phospholipids 1.39E-06 0.358 up up no no no no 18:1/18:0-PE+blood 16:0/16:1-PC+blood 0 0.639705882 0 serum_phospholipids serum_phospholipids 1.39E-06 0.00283 up up no up up no 18:1/18:0-PE+blood 16:0/18:0-PS+blood 0.69924812 0 0.414017094 serum_phospholipids serum_phospholipids 1.39E-06 0.377 up up no no no no 18:1/18:0-PE+blood 16:0/18:1-PE+blood 0.837593985 0.865196078 0.876923077 serum_phospholipids serum_phospholipids 1.39E-06 0.000107 up up no up up no 18:1/18:0-PE+blood 16:0/18:2-PC+blood -0.452631579 0 0 serum_phospholipids serum_phospholipids 1.39E-06 3.24E-06 up up no no up up 18:1/18:0-PE+blood 16:0/18:2-PI+blood 0 0.81372549 0 serum_phospholipids serum_phospholipids 1.39E-06 0.269 up up no no no no 18:1/18:0-PE+blood 16:0/20:3-PC+blood -0.50075188 0 0 serum_phospholipids serum_phospholipids 1.39E-06 5.43E-06 up up no no up up 18:1/18:0-PE+blood 16:0/20:4-PC+blood -0.544360902 -0.68872549 0 serum_phospholipids serum_phospholipids 1.39E-06 0.0262 up up no no up no 18:1/18:0-PE+blood 16:0/20:4-PE+blood 0.798496241 0.651960784 0.757264957 serum_phospholipids serum_phospholipids 1.39E-06 0.00139 up up no up up no 18:1/18:0-PE+blood 16:0/22:6-PC+blood 0 -0.620098039 0 serum_phospholipids serum_phospholipids 1.39E-06 4.53E-05 up up no no up up 18:1/18:0-PE+blood 16:0/22:6-PE+blood 0.827067669 0 0.823589744 serum_phospholipids serum_phospholipids 1.39E-06 0.000934 up up no up up no 18:1/18:0-PE+blood 16:1+blood 0 0 0.467350427 yes serum_phospholipids serum_fattyacid 1.39E-06 0.0186 up up no no no dn 18:1/18:0-PE+blood 18:0-LPA+blood 0.529323308 0 0 serum_phospholipids serum_phospholipids 1.39E-06 0.0725 up up no no dn no 18:1/18:0-PE+blood 18:0-LPE+blood 0.780451128 0 0.419487179 serum_phospholipids serum_phospholipids 1.39E-06 0.491 up up no no no no 18:1/18:0-PE+blood 18:0/18:0-PE+blood 0.696240602 0.75245098 0.599316239 serum_phospholipids serum_phospholipids 1.39E-06 0.00896 up up no up up no 18:1/18:0-PE+blood 18:0/18:0-PS+blood 0.476691729 0 0.450940171 serum_phospholipids serum_phospholipids 1.39E-06 0.00617 up up no no up no 18:1/18:0-PE+blood 18:0/18:1-PE+blood 0.747368421 0.821078431 0.685470085 serum_phospholipids serum_phospholipids 1.39E-06 0.00716 up up no up up no 18:1/18:0-PE+blood 18:0/18:1-PG+blood 0.630075188 0 0.451623932 serum_phospholipids serum_phospholipids 1.39E-06 0.000842 up up no no up no 18:1/18:0-PE+blood 18:0/18:1-PI+blood 0 0.492647059 0 serum_phospholipids serum_phospholipids 1.39E-06 0.599 up up no no no no 18:1/18:0-PE+blood 18:0/20:4-PC+blood -0.520300752 -0.772058824 0 serum_phospholipids serum_phospholipids 1.39E-06 0.454 up up no no no no 18:1/18:0-PE+blood 18:0/20:5-PC+blood 0 -0.759803922 0 serum_phospholipids serum_phospholipids 1.39E-06 0.17 up up no no no no 18:1/18:0-PE+blood 18:0/22:6-PE+blood 0.723308271 0 0.68957265 serum_phospholipids serum_phospholipids 1.39E-06 0.00022 up up no up up no 18:1/18:0-PE+blood 18:1/16:0-PC+blood -0.466165414 0 0 serum_phospholipids serum_phospholipids 1.39E-06 2.43E-05 up up no no up up 18:1/18:0-PE+blood 18:1/16:0-PE+blood 0.745864662 0.860294118 0.870769231 serum_phospholipids serum_phospholipids 1.39E-06 0.000182 up up no up up no 18:1/18:0-PE+blood 18:1/16:0-PI+blood 0 0.590686275 0 serum_phospholipids serum_phospholipids 1.39E-06 0.793 up up no no no no 18:1/18:0-PE+blood 18:1/16:1-PE+blood 0.842105263 0.852941176 0.844786325 serum_phospholipids serum_phospholipids 1.39E-06 0.000184 up up no up up no 18:1/18:0-PI+blood 12-HEPE+blood 0 0.523615897 0 serum_phospholipids serum_ARA 0.0931 0.312 no no up no no no 18:1/18:0-PI+blood 14:0-LPC+blood 0 0 0.424957265 serum_phospholipids serum_phospholipids 0.0931 0.00689 no no up up up no 18:1/18:0-PI+blood 14:1/18:2-PG+blood 0 0 0.408547009 serum_phospholipids serum_phospholipids 0.0931 0.00259 no no up no up up 18:1/18:0-PI+blood 15-HETE+blood -0.477286424 0 0 serum_phospholipids serum_ARA 0.0931 0.819 no no up no no no 18:1/18:0-PI+blood 16:0-LPC+blood 0 0 0.61025641 serum_phospholipids serum_phospholipids 0.0931 0.00456 no no up up up no 18:1/18:0-PI+blood 16:0/18:2-PI+blood 0 0 0.504957265 serum_phospholipids serum_phospholipids 0.0931 0.269 no no up no no no 18:1/18:0-PI+blood 16:0/20:5-PC+blood -0.511278195 0 0 serum_phospholipids serum_phospholipids 0.0931 0.628 no no up no no no 18:1/18:0-PI+blood 16:1/16:0-PC+blood 0 0 -0.457777778 serum_phospholipids serum_phospholipids 0.0931 0.0215 no no up no up up 18:1/18:0-PI+blood 16:1/16:1-PC+blood 0 0 -0.435897436 serum_phospholipids serum_phospholipids 0.0931 0.0177 no no up no no up 18:1/18:0-PI+blood 18:0-LPA+blood 0 0 0.496752137 serum_phospholipids serum_phospholipids 0.0931 0.0725 no no up no dn no 18:1/18:0-PI+blood 18:0-LPC+blood 0 0 0.481025641 serum_phospholipids serum_phospholipids 0.0931 0.554 no no up no no no 18:1/18:0-PI+blood 18:0/18:1-PI+blood 0.607518797 0.541666667 0.651282051 serum_phospholipids serum_phospholipids 0.0931 0.599 no no up no no no 18:1/18:0-PI+blood 18:0/18:2-PI+blood 0.612030075 0.617647059 0.843418803 serum_phospholipids serum_phospholipids 0.0931 0.179 no no up no no no 18:1/18:0-PI+blood 18:0/20:4-PI+blood 0.514285714 0 0 serum_phospholipids serum_phospholipids 0.0931 0.167 no no up no no no 18:1/18:0-PI+blood 18:0/20:5-PC+blood 0 -0.558823529 0 serum_phospholipids serum_phospholipids 0.0931 0.17 no no up no no no 18:1/18:0-PI+blood 18:1-LPE+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.0931 0.117 no no up no no no 18:1/18:0-PI+blood 18:1/16:0-PI+blood 0 0.509803922 0.747692308 serum_phospholipids serum_phospholipids 0.0931 0.793 no no up no no no 18:1/18:0-PS+blood 14:0-LPC+blood -0.494736842 0 0 serum_phospholipids serum_phospholipids 0.193 0.00689 no no no up up no 18:1/18:0-PS+blood 16:0/16:1-PI+blood -0.458646617 0 0 serum_phospholipids serum_phospholipids 0.193 0.262 no no no no no no 18:1/18:0-PS+blood 16:0/18:0-PS+blood 0.470676692 0.816176471 0.787350427 serum_phospholipids serum_phospholipids 0.193 0.377 no no no no no no 18:1/18:0-PS+blood 16:0/18:1-PC+blood 0.526315789 0 0 serum_phospholipids serum_phospholipids 0.193 6.15E-07 no no no up up up 18:1/18:0-PS+blood 16:0/18:2-PI+blood -0.496240602 0 0 serum_phospholipids serum_phospholipids 0.193 0.269 no no no no no no 18:1/18:0-PS+blood 16:0/20:5-PG+blood 0.569924812 0 0.564444444 serum_phospholipids serum_phospholipids 0.193 0.00656 no no no no up no 18:1/18:0-PS+blood 16:0/22:6-PE+blood 0 0.602941176 0 serum_phospholipids serum_phospholipids 0.193 0.000934 no no no up up no 18:1/18:0-PS+blood 16:0+blood 0 0.504901961 0 yes serum_phospholipids serum_fattyacid 0.193 0.00876 no no no up no no 18:1/18:0-PS+blood 16:1/16:0-PC+blood 0.484210526 0 0 serum_phospholipids serum_phospholipids 0.193 0.0215 no no no no up up 18:1/18:0-PS+blood 16:1/16:1-PC+blood 0.726315789 0 0 serum_phospholipids serum_phospholipids 0.193 0.0177 no no no no no up 18:1/18:0-PS+blood 16:1/18:1-PG+blood 0.718796992 0 0.504273504 serum_phospholipids serum_phospholipids 0.193 3.21E-05 no no no no up up 18:1/18:0-PS+blood 16:1/18:2-PG+blood 0.690225564 0 0.505641026 serum_phospholipids serum_phospholipids 0.193 1.40E-08 no no no no up up 18:1/18:0-PS+blood 18:0/16:0-PC+blood 0.539849624 0 0 serum_phospholipids serum_phospholipids 0.193 9.64E-07 no no no up up up 18:1/18:0-PS+blood 18:0/18:0-PS+blood 0.586466165 0.742647059 0.754529915 serum_phospholipids serum_phospholipids 0.193 0.00617 no no no no up no 18:1/18:0-PS+blood 18:0/18:2-PC+blood 0.448120301 0 0 serum_phospholipids serum_phospholipids 0.193 1.74E-06 no no no no up up 18:1/18:0-PS+blood 18:0/20:4-PI+blood 0 0.723039216 0.537777778 serum_phospholipids serum_phospholipids 0.193 0.167 no no no no no no 18:1/18:0-PS+blood 18:0/22:6-PA+blood 0.730827068 0.656862745 0.693675214 serum_phospholipids serum_phospholipids 0.193 0.22 no no no no no no 18:1/18:0-PS+blood 18:0/22:6-PE+blood 0 0.612745098 0 serum_phospholipids serum_phospholipids 0.193 0.00022 no no no up up no 18:1/18:0-PS+blood 18:0/22:6-PI+blood 0 0.593137255 0 serum_phospholipids serum_phospholipids 0.193 0.425 no no no no no no 18:1/18:0-PS+blood 18:0+blood 0 0.784313725 0 serum_phospholipids serum_fattyacid 0.193 0.344 no no no no no no 18:1/18:0-PS+blood 18:1/16:0-PI+blood -0.464661654 0 0 serum_phospholipids serum_phospholipids 0.193 0.793 no no no no no no 18:1/18:0-PS+blood 18:1/18:0-PC+blood 0.478195489 0 0 serum_phospholipids serum_phospholipids 0.193 1.83E-06 no no no no up up 18:1/18:1-PC+blood 11-HETE+blood 0 0.564973415 0 serum_phospholipids serum_ARA 1.34E-05 0.464 no up up no no no 18:1/18:1-PC+blood "12,13-EPOME+blood" 0 0 -0.428480668 serum_phospholipids serum_ARA 1.34E-05 0.901 no up up no no no 18:1/18:1-PC+blood 14:0/16:0-PC+blood 0 0.607843137 0 serum_phospholipids serum_phospholipids 1.34E-05 0.0358 no up up no up no 18:1/18:1-PC+blood 14:0/18:0-PC+blood 0 0.669117647 0.44957265 serum_phospholipids serum_phospholipids 1.34E-05 0.00289 no up up up up no 18:1/18:1-PC+blood 16:0-LPC+blood 0 -0.485294118 0 serum_phospholipids serum_phospholipids 1.34E-05 0.00456 no up up up up no 18:1/18:1-PC+blood 16:0-LPE+blood -0.819548872 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.0711 no up up up up no 18:1/18:1-PC+blood 16:0/14:0-PC+blood 0.484210526 0.602941176 0 serum_phospholipids serum_phospholipids 1.34E-05 0.0206 no up up no up up 18:1/18:1-PC+blood 16:0/16:0-PI+blood -0.633082707 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.358 no up up no no no 18:1/18:1-PC+blood 16:0/16:1-PC+blood 0 0.674019608 0.441367521 serum_phospholipids serum_phospholipids 1.34E-05 0.00283 no up up up up no 18:1/18:1-PC+blood 16:0/16:1-PI+blood -0.470676692 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.262 no up up no no no 18:1/18:1-PC+blood 16:0/18:0-PS+blood -0.50075188 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.377 no up up no no no 18:1/18:1-PC+blood 16:0/18:1-PC+blood 0.493233083 0 0.607521368 serum_phospholipids serum_phospholipids 1.34E-05 6.15E-07 no up up up up up 18:1/18:1-PC+blood 16:0/18:1-PE+blood -0.589473684 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.000107 no up up up up no 18:1/18:1-PC+blood 16:0/18:2-PC+blood 0.615037594 0 0.438632479 serum_phospholipids serum_phospholipids 1.34E-05 3.24E-06 no up up no up up 18:1/18:1-PC+blood 16:0/20:3-PC+blood 0.926315789 0.946078431 0.98017094 serum_phospholipids serum_phospholipids 1.34E-05 5.43E-06 no up up no up up 18:1/18:1-PC+blood 16:0/20:4-PC+blood 0.512781955 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.0262 no up up no up no 18:1/18:1-PC+blood 16:0/20:4-PE+blood -0.652631579 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.00139 no up up up up no 18:1/18:1-PC+blood 16:0/20:4-PI+blood -0.502255639 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.558 no up up no no no 18:1/18:1-PC+blood 16:0/20:5-PC+blood 0 0 -0.593162393 serum_phospholipids serum_phospholipids 1.34E-05 0.628 no up up no no no 18:1/18:1-PC+blood 16:0/22:6-PE+blood -0.589473684 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.000934 no up up up up no 18:1/18:1-PC+blood 16:1/18:1-PG+blood 0 0.56127451 0 serum_phospholipids serum_phospholipids 1.34E-05 3.21E-05 no up up no up up 18:1/18:1-PC+blood 16:1/18:2-PG+blood 0.514285714 0 0 serum_phospholipids serum_phospholipids 1.34E-05 1.40E-08 no up up no up up 18:1/18:1-PC+blood 18:0-LPE+blood -0.572932331 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.491 no up up no no no 18:1/18:1-PC+blood 18:0/16:0-PC+blood 0 0 0.58017094 serum_phospholipids serum_phospholipids 1.34E-05 9.64E-07 no up up up up up 18:1/18:1-PC+blood 18:0/18:0-PC+blood 0 0.519607843 0 serum_phospholipids serum_phospholipids 1.34E-05 0.426 no up up no no no 18:1/18:1-PC+blood 18:0/18:0-PE+blood -0.583458647 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.00896 no up up up up no 18:1/18:1-PC+blood 18:0/18:1-PC+blood 0 0.509803922 0 serum_phospholipids serum_phospholipids 1.34E-05 0.393 no up up no no no 18:1/18:1-PC+blood 18:0/18:1-PE+blood -0.604511278 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.00716 no up up up up no 18:1/18:1-PC+blood 18:0/18:1-PG+blood -0.448120301 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.000842 no up up no up no 18:1/18:1-PC+blood 18:0/18:1-PI+blood 0 0.539215686 0 serum_phospholipids serum_phospholipids 1.34E-05 0.599 no up up no no no 18:1/18:1-PC+blood 18:0/18:2-PC+blood 0.621052632 0.568627451 0.461880342 serum_phospholipids serum_phospholipids 1.34E-05 1.74E-06 no up up no up up 18:1/18:1-PC+blood 18:0/20:3-PC+blood 0 0.647058824 0.725811966 serum_phospholipids serum_phospholipids 1.34E-05 0.0682 no up up no up no 18:1/18:1-PC+blood 18:0/20:3-PI+blood 0 0.779411765 0 serum_phospholipids serum_phospholipids 1.34E-05 0.377 no up up no no no 18:1/18:1-PC+blood 18:0/20:4-PC+blood 0.463157895 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.454 no up up no no no 18:1/18:1-PC+blood 18:0/22:6-PE+blood -0.586466165 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.00022 no up up up up no 18:1/18:1-PC+blood 18:0/22:6-PI+blood -0.478195489 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.425 no up up no no no 18:1/18:1-PC+blood 18:1/16:0-PC+blood 0.571428571 0 0.424273504 serum_phospholipids serum_phospholipids 1.34E-05 2.43E-05 no up up no up up 18:1/18:1-PC+blood 18:1/16:0-PE+blood -0.64962406 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.000182 no up up up up no 18:1/18:1-PC+blood 18:1/16:0-PI+blood -0.476691729 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.793 no up up no no no 18:1/18:1-PC+blood 18:1/16:1-PE+blood -0.667669173 0 0 serum_phospholipids serum_phospholipids 1.34E-05 0.000184 no up up up up no 18:1/18:1-PC+blood 18:1/18:0-PC+blood 0.67518797 0.573529412 0.450940171 serum_phospholipids serum_phospholipids 1.34E-05 1.83E-06 no up up no up up 18:1/18:1-PC+blood 18:1/18:0-PE+blood -0.568421053 0 0 serum_phospholipids serum_phospholipids 1.34E-05 1.39E-06 no up up up up no 18:1/18:1-PC+blood Adrenergic signaling in cardiomyocytes 0.496491228 0 0 serum_phospholipids kegg 1.34E-05 NA no up up no no up 18:1/18:1-PC+blood Antigen processing and presentation 0 0.667647059 0 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Butyricimonas 0.544842127 0 0 butyrate-producing serum_phospholipids Genus 1.34E-05 0.17 no up up no no no 18:1/18:1-PC+blood Calcium signaling pathway 0.578947368 0 0 serum_phospholipids kegg 1.34E-05 NA no up up no up up 18:1/18:1-PC+blood CDCA+stool 0 0.627272727 0 serum_phospholipids stool_bileacids 1.34E-05 0.663 no up up no no no 18:1/18:1-PC+blood Cholinergic synapse 0 -0.517647059 0 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood DCA+stool 0 0 -0.452631579 serum_phospholipids stool_bileacids 1.34E-05 0.195 no up up no no no 18:1/18:1-PC+blood Epstein-Barr virus infection 0 0.744117647 0 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Ferroptosis 0 0 0.529230769 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Focal adhesion 0 0 -0.442307692 serum_phospholipids kegg 1.34E-05 NA no up up no up up 18:1/18:1-PC+blood FoxO signaling pathway 0 0 -0.475384615 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Fusobacterium 0 0 0.432714341 serum_phospholipids Genus 1.34E-05 0.628 no up up no no no 18:1/18:1-PC+blood Gastric cancer 0 0 -0.42 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood GCDCA+stool 0 0.654545455 0 yes serum_phospholipids stool_bileacids 1.34E-05 0.0471 no up up no dn no 18:1/18:1-PC+blood HDCA+stool 0 0 -0.52481203 serum_phospholipids stool_bileacids 1.34E-05 0.176 no up up no no no 18:1/18:1-PC+blood Hepatocellular carcinoma 0 0 -0.433846154 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Herpes simplex virus 1 infection 0 0.647058824 0 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Hippo signaling pathway 0 0 -0.443846154 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Human cytomegalovirus infection 0 0.670588235 0 serum_phospholipids kegg 1.34E-05 NA no up up no no dn 18:1/18:1-PC+blood Human immunodeficiency virus 1 infection 0 0.7 0 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Human T-cell leukemia virus 1 infection 0 0.679411765 0 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Intestinal immune network for IgA production 0.666666667 0 0 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Kaposi sarcoma-associated herpesvirus infection 0.531578947 0 0.48 serum_phospholipids kegg 1.34E-05 NA no up up no no dn 18:1/18:1-PC+blood Lachnospira 0 0 0.462329445 butyrate-producing serum_phospholipids Genus 1.34E-05 0.279 no up up no no no 18:1/18:1-PC+blood Malaria 0 0 0.46 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood MAPK signaling pathway 0 -0.644117647 0 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Mineral absorption 0 0 0.466923077 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Mitophagy - animal 0 0 0.418461538 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Necroptosis 0 0 0.445384615 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Olfactory transduction -0.59122807 0 0 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Pancreatic secretion 0.485964912 0 0 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Peroxisome -0.480701754 0 0 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Phenylacetic acid+stool 0 -0.736363636 0 serum_phospholipids stool_cometabolism 1.34E-05 0.785 no up up no no no 18:1/18:1-PC+blood Phosphatidylinositol signaling system 0 0 -0.429230769 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Platinum drug resistance 0 0 -0.403846154 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Prevotella -0.477784795 0 0 acetate-producing serum_phospholipids Genus 1.34E-05 0.287 no up up no no no 18:1/18:1-PC+blood Progesterone-mediated oocyte maturation 0 -0.55 0 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Ruminococcus 0.47518797 0 0 acetate-producing serum_phospholipids Genus 1.34E-05 0.335 no up up no no no 18:1/18:1-PC+blood Sphingolipid signaling pathway 0 0 -0.406153846 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood TCA+stool -0.59697443 0.718181818 0.527819549 serum_phospholipids stool_bileacids 1.34E-05 0.458 no up up no no no 18:1/18:1-PC+blood Th1 and Th2 cell differentiation 0.547368421 0 0 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Th17 cell differentiation 0.547368421 0 0 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Thyroid hormone signaling pathway 0 0 -0.484615385 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PC+blood Ubiquitin mediated proteolysis 0 0 0.417692308 serum_phospholipids kegg 1.34E-05 NA no up up no no no 18:1/18:1-PE+blood 11-HETE+blood 0 0.570709186 0 serum_phospholipids serum_ARA 1.03E-05 0.464 up up no no no no 18:1/18:1-PE+blood 12-ketoDCA+blood 0 -0.625704531 0 serum_phospholipids serum_bileacids 1.03E-05 0.517 up up no no no no 18:1/18:1-PE+blood 12-ketoDCA+stool 0 0 0.658646617 serum_phospholipids stool_bileacids 1.03E-05 0.505 up up no no no no 18:1/18:1-PE+blood "12,13-EPOME+blood" 0 0.587492391 0 serum_phospholipids serum_ARA 1.03E-05 0.901 up up no no no no 18:1/18:1-PE+blood 14:0/18:0-PC+blood 0 0.605392157 0 serum_phospholipids serum_phospholipids 1.03E-05 0.00289 up up no up up no 18:1/18:1-PE+blood 14:0+blood 0 0.492647059 0 yes serum_phospholipids serum_fattyacid 1.03E-05 0.00572 up up no up no dn 18:1/18:1-PE+blood 16:0-LPE+blood 0.518796992 0 0 serum_phospholipids serum_phospholipids 1.03E-05 0.0711 up up no up up no 18:1/18:1-PE+blood 16:0/14:0-PC+blood 0 0 -0.491965812 serum_phospholipids serum_phospholipids 1.03E-05 0.0206 up up no no up up 18:1/18:1-PE+blood 16:0/16:0-PI+blood 0.520300752 0 0 serum_phospholipids serum_phospholipids 1.03E-05 0.358 up up no no no no 18:1/18:1-PE+blood 16:0/16:1-PC+blood 0 0.637254902 0 serum_phospholipids serum_phospholipids 1.03E-05 0.00283 up up no up up no 18:1/18:1-PE+blood 16:0/18:0-PS+blood 0.727819549 0 0.431794872 serum_phospholipids serum_phospholipids 1.03E-05 0.377 up up no no no no 18:1/18:1-PE+blood 16:0/18:1-PE+blood 0.869172932 0.835784314 0.826324786 serum_phospholipids serum_phospholipids 1.03E-05 0.000107 up up no up up no 18:1/18:1-PE+blood 16:0/18:2-PC+blood -0.473684211 0 0 serum_phospholipids serum_phospholipids 1.03E-05 3.24E-06 up up no no up up 18:1/18:1-PE+blood 16:0/18:2-PI+blood 0 0.774509804 0 serum_phospholipids serum_phospholipids 1.03E-05 0.269 up up no no no no 18:1/18:1-PE+blood 16:0/20:3-PC+blood -0.458646617 0 0 serum_phospholipids serum_phospholipids 1.03E-05 5.43E-06 up up no no up up 18:1/18:1-PE+blood 16:0/20:4-PC+blood -0.518796992 -0.612745098 0 serum_phospholipids serum_phospholipids 1.03E-05 0.0262 up up no no up no 18:1/18:1-PE+blood 16:0/20:4-PE+blood 0.757894737 0.62254902 0.717606838 serum_phospholipids serum_phospholipids 1.03E-05 0.00139 up up no up up no 18:1/18:1-PE+blood 16:0/22:6-PE+blood 0.839097744 0 0.796239316 serum_phospholipids serum_phospholipids 1.03E-05 0.000934 up up no up up no 18:1/18:1-PE+blood 16:1+blood 0 0 0.470769231 yes serum_phospholipids serum_fattyacid 1.03E-05 0.0186 up up no no no dn 18:1/18:1-PE+blood 18:0-LPA+blood 0.503759398 0 0 serum_phospholipids serum_phospholipids 1.03E-05 0.0725 up up no no dn no 18:1/18:1-PE+blood 18:0-LPE+blood 0.703759398 0 0.426324786 serum_phospholipids serum_phospholipids 1.03E-05 0.491 up up no no no no 18:1/18:1-PE+blood 18:0/18:0-PE+blood 0.712781955 0.762254902 0.612307692 serum_phospholipids serum_phospholipids 1.03E-05 0.00896 up up no up up no 18:1/18:1-PE+blood 18:0/18:0-PS+blood 0.526315789 0 0.431111111 serum_phospholipids serum_phospholipids 1.03E-05 0.00617 up up no no up no 18:1/18:1-PE+blood 18:0/18:1-PE+blood 0.760902256 0.828431373 0.714871795 serum_phospholipids serum_phospholipids 1.03E-05 0.00716 up up no up up no 18:1/18:1-PE+blood 18:0/18:1-PG+blood 0.607518797 0 0.443418803 serum_phospholipids serum_phospholipids 1.03E-05 0.000842 up up no no up no 18:1/18:1-PE+blood 18:0/18:2-PI+blood 0.505263158 0 0 serum_phospholipids serum_phospholipids 1.03E-05 0.179 up up no no no no 18:1/18:1-PE+blood 18:0/20:4-PC+blood -0.493233083 -0.664215686 0 serum_phospholipids serum_phospholipids 1.03E-05 0.454 up up no no no no 18:1/18:1-PE+blood 18:0/20:5-PC+blood 0 -0.700980392 0 serum_phospholipids serum_phospholipids 1.03E-05 0.17 up up no no no no 18:1/18:1-PE+blood 18:0/22:6-PE+blood 0.694736842 0 0.633504274 serum_phospholipids serum_phospholipids 1.03E-05 0.00022 up up no up up no 18:1/18:1-PE+blood 18:1-LPC+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 1.03E-05 0.179 up up no no no no 18:1/18:1-PE+blood 18:1/16:0-PC+blood -0.49924812 0 0 serum_phospholipids serum_phospholipids 1.03E-05 2.43E-05 up up no no up up 18:1/18:1-PE+blood 18:1/16:0-PE+blood 0.792481203 0.828431373 0.848205128 serum_phospholipids serum_phospholipids 1.03E-05 0.000182 up up no up up no 18:1/18:1-PE+blood 18:1/16:0-PI+blood 0 0.512254902 0 serum_phospholipids serum_phospholipids 1.03E-05 0.793 up up no no no no 18:1/18:1-PE+blood 18:1/16:1-PE+blood 0.873684211 0.833333333 0.795555556 serum_phospholipids serum_phospholipids 1.03E-05 0.000184 up up no up up no 18:1/18:1-PE+blood 18:1/18:0-PE+blood 0.960902256 0.968137255 0.976068376 serum_phospholipids serum_phospholipids 1.03E-05 1.39E-06 up up no up up no 18:1/18:1-PE+blood 18:1/18:1-PC+blood -0.506766917 0 0 serum_phospholipids serum_phospholipids 1.03E-05 1.34E-05 up up no no up up 18:1/18:1-PE+blood 18:1+blood 0 0 0.442735043 yes serum_phospholipids serum_fattyacid 1.03E-05 0.00202 up up no up no dn 18:1/18:1-PE+blood Antigen processing and presentation 0 0 0.550769231 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood Cell adhesion molecules 0 0 0.429230769 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood Clostridium 0 0.485077898 0 serum_phospholipids Genus 1.03E-05 0.925 up up no no no no 18:1/18:1-PE+blood DCA+stool 0 0 0.45112782 serum_phospholipids stool_bileacids 1.03E-05 0.195 up up no no no no 18:1/18:1-PE+blood Epstein-Barr virus infection 0 0 0.441538462 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood Ferroptosis -0.584210526 0 0 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood Herpes simplex virus 1 infection 0 0 0.452307692 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood Human cytomegalovirus infection 0 0 0.510769231 serum_phospholipids kegg 1.03E-05 NA up up no no no dn 18:1/18:1-PE+blood Human immunodeficiency virus 1 infection 0 0 0.502307692 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood Human T-cell leukemia virus 1 infection 0 0 0.543076923 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood Intestinal immune network for IgA production -0.552631579 0 0 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood Kaposi sarcoma-associated herpesvirus infection -0.496491228 0 0 serum_phospholipids kegg 1.03E-05 NA up up no no no dn 18:1/18:1-PE+blood L-Phenylalanine+stool 0.686813187 0 0 serum_phospholipids stool_cometabolism 1.03E-05 0.398 up up no no no no 18:1/18:1-PE+blood L-Tryptophan+stool 0.598901099 0 0 serum_phospholipids stool_cometabolism 1.03E-05 0.557 up up no no no no 18:1/18:1-PE+blood L-Tyrosine+stool 0.582417582 0 -0.50075188 serum_phospholipids stool_cometabolism 1.03E-05 0.44 up up no no no no 18:1/18:1-PE+blood LCA+stool 0 0 0.463157895 serum_phospholipids stool_bileacids 1.03E-05 0.314 up up no no no no 18:1/18:1-PE+blood Lipid and atherosclerosis 0 0 0.416923077 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood Longevity regulating pathway - multiple species 0.477192982 0 0 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood MAPK signaling pathway 0 -0.617647059 0 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood Measles 0 -0.588235294 0 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood Parabacteroides 0 -0.56127451 0 serum_phospholipids Genus 1.03E-05 4.19E-05 up up no no up up 18:1/18:1-PE+blood Pertussis 0 0 0.422307692 serum_phospholipids kegg 1.03E-05 NA up up no no no dn 18:1/18:1-PE+blood PPAR signaling pathway 0 0 0.469230769 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood Primary immunodeficiency 0.489473684 0 0 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood Ruminococcus 0 0.526057732 0 serum_phospholipids Genus 1.03E-05 0.0679 up up no no no dn 18:1/18:1-PE+blood Systemic lupus erythematosus 0 0 0.451538462 serum_phospholipids kegg 1.03E-05 NA up up no no no no 18:1/18:1-PE+blood TCA+stool 0 0.636363636 0 serum_phospholipids stool_bileacids 1.03E-05 0.458 up up no no no no 18:1/18:1-PG+blood 11-HETE+blood 0 0.636670549 0 serum_phospholipids serum_ARA 0.00352 0.464 no up up no no no 18:1/18:1-PG+blood 13-HODE+blood 0 0 -0.442735043 serum_phospholipids serum_ARA 0.00352 0.32 no up up no no no 18:1/18:1-PG+blood 14:0-LPC+blood -0.481203008 0 0 serum_phospholipids serum_phospholipids 0.00352 0.00689 no up up up up no 18:1/18:1-PG+blood 14:0/16:0-PC+blood 0 0.664215686 0 serum_phospholipids serum_phospholipids 0.00352 0.0358 no up up no up no 18:1/18:1-PG+blood 14:0/18:0-PC+blood 0 0.649509804 0 serum_phospholipids serum_phospholipids 0.00352 0.00289 no up up up up no 18:1/18:1-PG+blood 14:0+blood 0 0 -0.466666667 yes serum_phospholipids serum_fattyacid 0.00352 0.00572 no up up up no dn 18:1/18:1-PG+blood 16:0/16:1-PC+blood 0 0.705882353 0 serum_phospholipids serum_phospholipids 0.00352 0.00283 no up up up up no 18:1/18:1-PG+blood 16:0/16:1-PI+blood 0 0.735294118 0 serum_phospholipids serum_phospholipids 0.00352 0.262 no up up no no no 18:1/18:1-PG+blood 16:0/18:0-PS+blood 0 0 0.485811966 serum_phospholipids serum_phospholipids 0.00352 0.377 no up up no no no 18:1/18:1-PG+blood 16:0/18:1-PC+blood 0.533834586 0 0 serum_phospholipids serum_phospholipids 0.00352 6.15E-07 no up up up up up 18:1/18:1-PG+blood 16:0/18:2-PI+blood -0.482706767 0 0 serum_phospholipids serum_phospholipids 0.00352 0.269 no up up no no no 18:1/18:1-PG+blood 16:0/20:3-PC+blood 0 0.593137255 0 serum_phospholipids serum_phospholipids 0.00352 5.43E-06 no up up no up up 18:1/18:1-PG+blood 16:0/20:5-PG+blood 0.539849624 0 0.628034188 serum_phospholipids serum_phospholipids 0.00352 0.00656 no up up no up no 18:1/18:1-PG+blood 16:1/18:1-PG+blood 0.819548872 0.781862745 0.772307692 serum_phospholipids serum_phospholipids 0.00352 3.21E-05 no up up no up up 18:1/18:1-PG+blood 16:1/18:2-PG+blood 0.603007519 0.504901961 0.762735043 serum_phospholipids serum_phospholipids 0.00352 1.40E-08 no up up no up up 18:1/18:1-PG+blood 18:0/16:0-PC+blood 0.520300752 0 0 serum_phospholipids serum_phospholipids 0.00352 9.64E-07 no up up up up up 18:1/18:1-PG+blood 18:0/18:0-PC+blood 0.577443609 0.710784314 0 serum_phospholipids serum_phospholipids 0.00352 0.426 no up up no no no 18:1/18:1-PG+blood 18:0/18:0-PS+blood 0 0.534313725 0.494700855 serum_phospholipids serum_phospholipids 0.00352 0.00617 no up up no up no 18:1/18:1-PG+blood 18:0/18:1-PC+blood 0.6 0.740196078 0 serum_phospholipids serum_phospholipids 0.00352 0.393 no up up no no no 18:1/18:1-PG+blood 18:0/18:1-PG+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.00352 0.000842 no up up no up no 18:1/18:1-PG+blood 18:0/18:1-PI+blood 0 0.575980392 0 serum_phospholipids serum_phospholipids 0.00352 0.599 no up up no no no 18:1/18:1-PG+blood 18:0/18:2-PI+blood 0 0 0.407179487 serum_phospholipids serum_phospholipids 0.00352 0.179 no up up no no no 18:1/18:1-PG+blood 18:0/20:3-PC+blood 0 0.710784314 0 serum_phospholipids serum_phospholipids 0.00352 0.0682 no up up no up no 18:1/18:1-PG+blood 18:0/20:3-PI+blood 0 0.676470588 0 serum_phospholipids serum_phospholipids 0.00352 0.377 no up up no no no 18:1/18:1-PG+blood 18:0/20:5-PC+blood 0 -0.519607843 0 serum_phospholipids serum_phospholipids 0.00352 0.17 no up up no no no 18:1/18:1-PG+blood 18:0/22:6-PA+blood 0.621052632 0 0 serum_phospholipids serum_phospholipids 0.00352 0.22 no up up no no no 18:1/18:1-PG+blood 18:0+blood 0 0.595588235 0 serum_phospholipids serum_fattyacid 0.00352 0.344 no up up no no no 18:1/18:1-PG+blood 18:1/16:0-PI+blood 0 0.512254902 0 serum_phospholipids serum_phospholipids 0.00352 0.793 no up up no no no 18:1/18:1-PG+blood 18:1/18:0-PS+blood 0.645112782 0 0.465299145 serum_phospholipids serum_phospholipids 0.00352 0.193 no up up no no no 18:1/18:1-PG+blood 18:1/18:1-PC+blood 0 0.661764706 0 serum_phospholipids serum_phospholipids 0.00352 1.34E-05 no up up no up up 18:1/18:1-PG+blood 18:1/18:1-PE+blood 0 0.573529412 0 serum_phospholipids serum_phospholipids 0.00352 1.03E-05 no up up up up no 18:1/18:1-PI+blood 16:0/16:1-PI+blood 0 0.566176471 0 serum_phospholipids serum_phospholipids 0.111 0.262 dn no no no no no 18:1/18:1-PI+blood 16:0/18:3-PC+blood -0.457142857 -0.487745098 0 serum_phospholipids serum_phospholipids 0.111 0.00216 dn no no no up up 18:1/18:1-PI+blood 16:0/20:4-PC+blood 0 -0.522058824 0 serum_phospholipids serum_phospholipids 0.111 0.0262 dn no no no up no 18:1/18:1-PI+blood 16:0/20:5-PC+blood 0 0 -0.418119658 serum_phospholipids serum_phospholipids 0.111 0.628 dn no no no no no 18:1/18:1-PI+blood 16:0/22:6-PC+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 0.111 4.53E-05 dn no no no up up 18:1/18:1-PI+blood 16:1/16:1-PC+blood 0 0 -0.496752137 serum_phospholipids serum_phospholipids 0.111 0.0177 dn no no no no up 18:1/18:1-PI+blood 16:1/18:1-PG+blood 0 0.644607843 0 serum_phospholipids serum_phospholipids 0.111 3.21E-05 dn no no no up up 18:1/18:1-PI+blood 18:0-LPC+blood 0 0 0.401025641 serum_phospholipids serum_phospholipids 0.111 0.554 dn no no no no no 18:1/18:1-PI+blood 18:0/18:1-PI+blood 0.669172932 0.887254902 0.785982906 serum_phospholipids serum_phospholipids 0.111 0.599 dn no no no no no 18:1/18:1-PI+blood 18:0/18:2-PI+blood 0 0 0.427692308 serum_phospholipids serum_phospholipids 0.111 0.179 dn no no no no no 18:1/18:1-PI+blood 18:0/20:3-PI+blood 0 0.529411765 0 serum_phospholipids serum_phospholipids 0.111 0.377 dn no no no no no 18:1/18:1-PI+blood 18:1-LPC+blood 0.562406015 0 0 serum_phospholipids serum_phospholipids 0.111 0.179 dn no no no no no 18:1/18:1-PI+blood 18:1/16:0-PI+blood 0.466165414 0.794117647 0.525470085 serum_phospholipids serum_phospholipids 0.111 0.793 dn no no no no no 18:1/18:1-PI+blood 18:1/16:1-PE+blood 0 0 -0.403076923 serum_phospholipids serum_phospholipids 0.111 0.000184 dn no no up up no 18:1/18:1-PI+blood 18:1/18:0-PI+blood 0.532330827 0.495098039 0.525470085 serum_phospholipids serum_phospholipids 0.111 0.0931 dn no no no no up 18:1/18:2-PE+blood 13-HODE+blood -0.484210526 0 0 serum_phospholipids serum_ARA 0.000293 0.32 up up no no no no 18:1/18:2-PE+blood 14:0/18:0-PC+blood 0 0.522058824 0 serum_phospholipids serum_phospholipids 0.000293 0.00289 up up no up up no 18:1/18:2-PE+blood 16:0-LPE+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.000293 0.0711 up up no up up no 18:1/18:2-PE+blood 16:0/14:0-PC+blood 0 0 -0.52 serum_phospholipids serum_phospholipids 0.000293 0.0206 up up no no up up 18:1/18:2-PE+blood 16:0/16:0-PI+blood 0 0.487745098 0 serum_phospholipids serum_phospholipids 0.000293 0.358 up up no no no no 18:1/18:2-PE+blood 16:0/16:1-PC+blood 0 0.522058824 0 serum_phospholipids serum_phospholipids 0.000293 0.00283 up up no up up no 18:1/18:2-PE+blood 16:0/18:1-PC+blood -0.521804511 0 0 serum_phospholipids serum_phospholipids 0.000293 6.15E-07 up up no up up up 18:1/18:2-PE+blood 16:0/18:1-PE+blood 0.783458647 0.803921569 0.666324786 serum_phospholipids serum_phospholipids 0.000293 0.000107 up up no up up no 18:1/18:2-PE+blood 16:0/18:2-PC+blood -0.639097744 0 0 serum_phospholipids serum_phospholipids 0.000293 3.24E-06 up up no no up up 18:1/18:2-PE+blood 16:0/18:2-PI+blood 0 0.786764706 0 serum_phospholipids serum_phospholipids 0.000293 0.269 up up no no no no 18:1/18:2-PE+blood 16:0/20:4-PC+blood -0.532330827 -0.789215686 0 serum_phospholipids serum_phospholipids 0.000293 0.0262 up up no no up no 18:1/18:2-PE+blood 16:0/20:4-PE+blood 0.529323308 0.651960784 0.627350427 serum_phospholipids serum_phospholipids 0.000293 0.00139 up up no up up no 18:1/18:2-PE+blood 16:0/22:6-PC+blood -0.485714286 -0.681372549 0 serum_phospholipids serum_phospholipids 0.000293 4.53E-05 up up no no up up 18:1/18:2-PE+blood 16:0/22:6-PE+blood 0.65112782 0 0.665641026 serum_phospholipids serum_phospholipids 0.000293 0.000934 up up no up up no 18:1/18:2-PE+blood 16:1/16:0-PC+blood -0.541353383 0 0 serum_phospholipids serum_phospholipids 0.000293 0.0215 up up no no up up 18:1/18:2-PE+blood 18:0-LPE+blood 0.45112782 0 0.490598291 serum_phospholipids serum_phospholipids 0.000293 0.491 up up no no no no 18:1/18:2-PE+blood 18:0/16:0-PC+blood -0.518796992 0 0 serum_phospholipids serum_phospholipids 0.000293 9.64E-07 up up no up up up 18:1/18:2-PE+blood 18:0/18:0-PE+blood 0.672180451 0.767156863 0.610940171 serum_phospholipids serum_phospholipids 0.000293 0.00896 up up no up up no 18:1/18:2-PE+blood 18:0/18:1-PE+blood 0.682706767 0.776960784 0.715555556 serum_phospholipids serum_phospholipids 0.000293 0.00716 up up no up up no 18:1/18:2-PE+blood 18:0/18:1-PI+blood 0 0.556372549 0 serum_phospholipids serum_phospholipids 0.000293 0.599 up up no no no no 18:1/18:2-PE+blood 18:0/18:2-PC+blood 0 0 -0.40034188 serum_phospholipids serum_phospholipids 0.000293 1.74E-06 up up no no up up 18:1/18:2-PE+blood 18:0/18:2-PI+blood 0.44962406 0 0 serum_phospholipids serum_phospholipids 0.000293 0.179 up up no no no no 18:1/18:2-PE+blood 18:0/20:4-PC+blood -0.496240602 -0.799019608 0 serum_phospholipids serum_phospholipids 0.000293 0.454 up up no no no no 18:1/18:2-PE+blood 18:0/20:5-PC+blood 0 -0.786764706 0 serum_phospholipids serum_phospholipids 0.000293 0.17 up up no no no no 18:1/18:2-PE+blood 18:0/22:6-PA+blood 0 0 -0.404444444 serum_phospholipids serum_phospholipids 0.000293 0.22 up up no no no no 18:1/18:2-PE+blood 18:0/22:6-PE+blood 0 0 0.438632479 serum_phospholipids serum_phospholipids 0.000293 0.00022 up up no up up no 18:1/18:2-PE+blood 18:1-LPE+blood 0.557894737 0 0 serum_phospholipids serum_phospholipids 0.000293 0.117 up up no no no no 18:1/18:2-PE+blood 18:1/16:0-PC+blood -0.681203008 0 0 serum_phospholipids serum_phospholipids 0.000293 2.43E-05 up up no no up up 18:1/18:2-PE+blood 18:1/16:0-PE+blood 0.727819549 0.850490196 0.727179487 serum_phospholipids serum_phospholipids 0.000293 0.000182 up up no up up no 18:1/18:2-PE+blood 18:1/16:0-PI+blood 0 0.661764706 0 serum_phospholipids serum_phospholipids 0.000293 0.793 up up no no no no 18:1/18:2-PE+blood 18:1/16:1-PE+blood 0.678195489 0.791666667 0.627350427 serum_phospholipids serum_phospholipids 0.000293 0.000184 up up no up up no 18:1/18:2-PE+blood 18:1/18:0-PC+blood -0.473684211 0 -0.408547009 serum_phospholipids serum_phospholipids 0.000293 1.83E-06 up up no no up up 18:1/18:2-PE+blood 18:1/18:0-PE+blood 0.747368421 0.906862745 0.822905983 serum_phospholipids serum_phospholipids 0.000293 1.39E-06 up up no up up no 18:1/18:2-PE+blood 18:1/18:0-PI+blood 0 0.610294118 0 serum_phospholipids serum_phospholipids 0.000293 0.0931 up up no no no up 18:1/18:2-PE+blood 18:1/18:1-PE+blood 0.792481203 0.860294118 0.832478632 serum_phospholipids serum_phospholipids 0.000293 1.03E-05 up up no up up no 18:1/18:2-PG+blood 11-HETE+blood 0 0.513351479 0 serum_phospholipids serum_ARA 5.58E-07 0.464 no up up no no no 18:1/18:2-PG+blood 13-HODE+blood 0 0 -0.438632479 serum_phospholipids serum_ARA 5.58E-07 0.32 no up up no no no 18:1/18:2-PG+blood 14:0+blood 0 0 -0.439316239 yes serum_phospholipids serum_fattyacid 5.58E-07 0.00572 no up up up no dn 18:1/18:2-PG+blood 16:0-LPE+blood -0.57593985 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.0711 no up up up up no 18:1/18:2-PG+blood 16:0/14:0-PC+blood 0.512781955 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.0206 no up up no up up 18:1/18:2-PG+blood 16:0/16:0-PI+blood -0.487218045 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.358 no up up no no no 18:1/18:2-PG+blood 16:0/16:1-PC+blood 0 0.504901961 0 serum_phospholipids serum_phospholipids 5.58E-07 0.00283 no up up up up no 18:1/18:2-PG+blood 16:0/16:1-PI+blood -0.557894737 0.573529412 0 serum_phospholipids serum_phospholipids 5.58E-07 0.262 no up up no no no 18:1/18:2-PG+blood 16:0/18:0-PS+blood 0 0 0.427008547 serum_phospholipids serum_phospholipids 5.58E-07 0.377 no up up no no no 18:1/18:2-PG+blood 16:0/18:1-PC+blood 0.616541353 0 0 serum_phospholipids serum_phospholipids 5.58E-07 6.15E-07 no up up up up up 18:1/18:2-PG+blood 16:0/18:1-PE+blood -0.445112782 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.000107 no up up up up no 18:1/18:2-PG+blood 16:0/18:2-PC+blood 0.587969925 0 0 serum_phospholipids serum_phospholipids 5.58E-07 3.24E-06 no up up no up up 18:1/18:2-PG+blood 16:0/20:3-PC+blood 0.669172932 0 0 serum_phospholipids serum_phospholipids 5.58E-07 5.43E-06 no up up no up up 18:1/18:2-PG+blood 16:0/20:4-PI+blood -0.521804511 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.558 no up up no no no 18:1/18:2-PG+blood 16:0/20:5-PG+blood 0.514285714 0 0.716923077 serum_phospholipids serum_phospholipids 5.58E-07 0.00656 no up up no up no 18:1/18:2-PG+blood 16:1/16:0-PC+blood 0.533834586 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.0215 no up up no up up 18:1/18:2-PG+blood 16:1/16:1-PC+blood 0.57593985 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.0177 no up up no no up 18:1/18:2-PG+blood 16:1/18:1-PG+blood 0.760902256 0.74754902 0.624615385 serum_phospholipids serum_phospholipids 5.58E-07 3.21E-05 no up up no up up 18:1/18:2-PG+blood 16:1/18:2-PG+blood 0.968421053 0.816176471 0.901538462 serum_phospholipids serum_phospholipids 5.58E-07 1.40E-08 no up up no up up 18:1/18:2-PG+blood 18:0/16:0-PC+blood 0.560902256 0 0 serum_phospholipids serum_phospholipids 5.58E-07 9.64E-07 no up up up up up 18:1/18:2-PG+blood 18:0/18:0-PC+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 5.58E-07 0.426 no up up no no no 18:1/18:2-PG+blood 18:0/18:0-PE+blood -0.606015038 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.00896 no up up up up no 18:1/18:2-PG+blood 18:0/18:0-PS+blood 0 0 0.442051282 serum_phospholipids serum_phospholipids 5.58E-07 0.00617 no up up no up no 18:1/18:2-PG+blood 18:0/18:1-PC+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 5.58E-07 0.393 no up up no no no 18:1/18:2-PG+blood 18:0/18:1-PE+blood -0.630075188 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.00716 no up up up up no 18:1/18:2-PG+blood 18:0/18:1-PI+blood 0 0.605392157 0 serum_phospholipids serum_phospholipids 5.58E-07 0.599 no up up no no no 18:1/18:2-PG+blood 18:0/18:2-PC+blood 0.687218045 0 0 serum_phospholipids serum_phospholipids 5.58E-07 1.74E-06 no up up no up up 18:1/18:2-PG+blood 18:0/18:2-PI+blood 0 0.534313725 0.44 serum_phospholipids serum_phospholipids 5.58E-07 0.179 no up up no no no 18:1/18:2-PG+blood 18:0/20:3-PI+blood 0.460150376 0.583333333 0 serum_phospholipids serum_phospholipids 5.58E-07 0.377 no up up no no no 18:1/18:2-PG+blood 18:0/20:5-PC+blood 0 -0.536764706 0 serum_phospholipids serum_phospholipids 5.58E-07 0.17 no up up no no no 18:1/18:2-PG+blood 18:0/22:6-PA+blood 0.52481203 0 0.71965812 serum_phospholipids serum_phospholipids 5.58E-07 0.22 no up up no no no 18:1/18:2-PG+blood 18:0+blood 0 0.588235294 0 serum_phospholipids serum_fattyacid 5.58E-07 0.344 no up up no no no 18:1/18:2-PG+blood 18:1/16:0-PC+blood 0.593984962 0 0 serum_phospholipids serum_phospholipids 5.58E-07 2.43E-05 no up up no up up 18:1/18:2-PG+blood 18:1/16:0-PE+blood -0.554887218 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.000182 no up up up up no 18:1/18:2-PG+blood 18:1/16:0-PI+blood -0.479699248 0.558823529 0 serum_phospholipids serum_phospholipids 5.58E-07 0.793 no up up no no no 18:1/18:2-PG+blood 18:1/16:1-PE+blood -0.445112782 0 0 serum_phospholipids serum_phospholipids 5.58E-07 0.000184 no up up up up no 18:1/18:2-PG+blood 18:1/18:0-PC+blood 0.688721805 0 0 serum_phospholipids serum_phospholipids 5.58E-07 1.83E-06 no up up no up up 18:1/18:2-PG+blood 18:1/18:0-PS+blood 0.705263158 0.487745098 0.628034188 serum_phospholipids serum_phospholipids 5.58E-07 0.193 no up up no no no 18:1/18:2-PG+blood 18:1/18:1-PC+blood 0.541353383 0.519607843 0 serum_phospholipids serum_phospholipids 5.58E-07 1.34E-05 no up up no up up 18:1/18:2-PG+blood 18:1/18:1-PE+blood 0 0.492647059 0 serum_phospholipids serum_phospholipids 5.58E-07 1.03E-05 no up up up up no 18:1/18:2-PG+blood 18:1/18:1-PG+blood 0.655639098 0.855392157 0.747008547 serum_phospholipids serum_phospholipids 5.58E-07 0.00352 no up up no up up 18:1/18:2-PG+blood 18:1/18:1-PI+blood 0 0.49754902 0 serum_phospholipids serum_phospholipids 5.58E-07 0.111 no up up dn no no 18:1/18:2-PG+blood 18:1+blood 0 0 -0.542564103 yes serum_phospholipids serum_fattyacid 5.58E-07 0.00202 no up up up no dn 18:1/18:2-PG+blood Akkermansia 0 0 -0.485511029 acetate-producing serum_phospholipids Genus 5.58E-07 0.23 no up up no no no 18:1/18:2-PG+blood Biosynthesis of cofactors 0 -0.511764706 0 serum_phospholipids kegg 5.58E-07 NA no up up no no no 18:1/18:2-PG+blood Coprococcus -0.455639098 0 0 butyrate-producing serum_phospholipids Genus 5.58E-07 0.612 no up up no no no 18:1/18:2-PG+blood "Glycine, serine and threonine metabolism" 0 -0.5 0 serum_phospholipids kegg 5.58E-07 NA no up up no up no 18:1/18:2-PG+blood mRNA surveillance pathway 0 0 0.402307692 serum_phospholipids kegg 5.58E-07 NA no up up no no no 18:1/18:2-PG+blood NOD-like receptor signaling pathway 0 0 -0.410769231 serum_phospholipids kegg 5.58E-07 NA no up up no no no 18:1/18:2-PG+blood Parabacteroides 0.554887218 0 0 serum_phospholipids Genus 5.58E-07 4.19E-05 no up up no up up 18:1/18:2-PG+blood Pertussis 0 0 -0.407692308 serum_phospholipids kegg 5.58E-07 NA no up up no no dn 18:1/18:2-PG+blood Staphylococcus aureus infection 0 0 -0.409230769 serum_phospholipids kegg 5.58E-07 NA no up up up no no 18:1/18:2-PG+blood Toxoplasmosis 0 0 -0.409230769 serum_phospholipids kegg 5.58E-07 NA no up up no no no 18:1/18:2-PI+blood 16:0/16:0-PC+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.0164 0.00079 dn no up no up up 18:1/18:2-PI+blood 16:0/16:1-PC+blood -0.455639098 0 0 serum_phospholipids serum_phospholipids 0.0164 0.00283 dn no up up up no 18:1/18:2-PI+blood 16:0/18:0-PC+blood 0 0 0.414017094 serum_phospholipids serum_phospholipids 0.0164 0.521 dn no up no no no 18:1/18:2-PI+blood 16:0/18:0-PS+blood 0 0 -0.574700855 serum_phospholipids serum_phospholipids 0.0164 0.377 dn no up no no no 18:1/18:2-PI+blood 16:0/20:5-PC+blood -0.49924812 0 0 serum_phospholipids serum_phospholipids 0.0164 0.628 dn no up no no no 18:1/18:2-PI+blood 16:1/18:1-PG+blood 0 0 -0.577435897 serum_phospholipids serum_phospholipids 0.0164 3.21E-05 dn no up no up up 18:1/18:2-PI+blood 18:0-LPC+blood 0 0 0.466666667 serum_phospholipids serum_phospholipids 0.0164 0.554 dn no up no no no 18:1/18:2-PI+blood 18:0/18:0-PC+blood -0.454135338 0 0 serum_phospholipids serum_phospholipids 0.0164 0.426 dn no up no no no 18:1/18:2-PI+blood 18:0/18:0-PS+blood 0 0 -0.474871795 serum_phospholipids serum_phospholipids 0.0164 0.00617 dn no up no up no 18:1/18:2-PI+blood 18:0/18:1-PG+blood 0 0 -0.404444444 serum_phospholipids serum_phospholipids 0.0164 0.000842 dn no up no up no 18:1/18:2-PI+blood 18:0/18:2-PI+blood 0.562406015 0 0 serum_phospholipids serum_phospholipids 0.0164 0.179 dn no up no no no 18:1/18:2-PI+blood 18:1-LPC+blood 0 0.5 0 serum_phospholipids serum_phospholipids 0.0164 0.179 dn no up no no no 18:1/18:2-PI+blood 18:1-LPE+blood 0 0 0.451623932 serum_phospholipids serum_phospholipids 0.0164 0.117 dn no up no no no 18:1/18:2-PI+blood 18:1/18:0-PS+blood 0 0 -0.511794872 serum_phospholipids serum_phospholipids 0.0164 0.193 dn no up no no no 18:1/18:2-PI+blood 18:1/18:1-PG+blood 0 0 -0.403760684 serum_phospholipids serum_phospholipids 0.0164 0.00352 dn no up no up up 18:1/18:2-PI+blood 18:1/18:1-PI+blood 0 0.593137255 0 serum_phospholipids serum_phospholipids 0.0164 0.111 dn no up dn no no 18:1/18:2-PI+blood Slackia 0 0 0.44566099 serum_phospholipids Genus 0.0164 0.94 dn no up no no no 18:1/20:3-PC+blood "12,13-EPOME+blood" 0 0 -0.601746075 serum_phospholipids serum_ARA 0.00872 0.901 no up up no no no 18:1/20:3-PC+blood 16:0-LPE+blood -0.663157895 0 0 serum_phospholipids serum_phospholipids 0.00872 0.0711 no up up up up no 18:1/20:3-PC+blood 16:0/16:0-PI+blood -0.479699248 0 0 serum_phospholipids serum_phospholipids 0.00872 0.358 no up up no no no 18:1/20:3-PC+blood 16:0/20:3-PC+blood 0.796992481 0.718137255 0.827008547 serum_phospholipids serum_phospholipids 0.00872 5.43E-06 no up up no up up 18:1/20:3-PC+blood 16:0/20:4-PC+blood 0 0 0.494700855 serum_phospholipids serum_phospholipids 0.00872 0.0262 no up up no up no 18:1/20:3-PC+blood 16:0/20:4-PE+blood -0.536842105 0 0 serum_phospholipids serum_phospholipids 0.00872 0.00139 no up up up up no 18:1/20:3-PC+blood 16:0/20:5-PC+blood 0 -0.482843137 -0.504273504 serum_phospholipids serum_phospholipids 0.00872 0.628 no up up no no no 18:1/20:3-PC+blood 18:0-LPA+blood -0.472180451 0 0 serum_phospholipids serum_phospholipids 0.00872 0.0725 no up up no dn no 18:1/20:3-PC+blood 18:0/18:0-PS+blood 0 0 -0.421538462 serum_phospholipids serum_phospholipids 0.00872 0.00617 no up up no up no 18:1/20:3-PC+blood 18:0/18:1-PE+blood -0.485714286 0 0 serum_phospholipids serum_phospholipids 0.00872 0.00716 no up up up up no 18:1/20:3-PC+blood 18:0/18:2-PC+blood 0 0 0.416752137 serum_phospholipids serum_phospholipids 0.00872 1.74E-06 no up up no up up 18:1/20:3-PC+blood 18:0/20:2-PC+blood 0 0.593137255 0.40991453 serum_phospholipids serum_phospholipids 0.00872 0.733 no up up no no no 18:1/20:3-PC+blood 18:0/20:3-PC+blood 0 0.56372549 0.733333333 serum_phospholipids serum_phospholipids 0.00872 0.0682 no up up no up no 18:1/20:3-PC+blood 18:0/20:3-PI+blood 0 0.524509804 0 serum_phospholipids serum_phospholipids 0.00872 0.377 no up up no no no 18:1/20:3-PC+blood 18:0/20:4-PC+blood 0 0 0.501538462 serum_phospholipids serum_phospholipids 0.00872 0.454 no up up no no no 18:1/20:3-PC+blood 18:0/22:6-PE+blood -0.533834586 -0.549019608 0 serum_phospholipids serum_phospholipids 0.00872 0.00022 no up up up up no 18:1/20:3-PC+blood 18:1/16:0-PE+blood -0.488721805 0 0 serum_phospholipids serum_phospholipids 0.00872 0.000182 no up up up up no 18:1/20:3-PC+blood 18:1/16:0-PI+blood -0.551879699 0 0 serum_phospholipids serum_phospholipids 0.00872 0.793 no up up no no no 18:1/20:3-PC+blood 18:1/18:0-PC+blood 0 0 0.403760684 serum_phospholipids serum_phospholipids 0.00872 1.83E-06 no up up no up up 18:1/20:3-PC+blood 18:1/18:1-PC+blood 0.771428571 0.710784314 0.773675214 serum_phospholipids serum_phospholipids 0.00872 1.34E-05 no up up no up up 18:1/20:3-PC+blood 18:1/18:2-PG+blood 0.485714286 0 0 serum_phospholipids serum_phospholipids 0.00872 5.58E-07 no up up no up up 18:1/20:3-PC+blood Adipocytokine signaling pathway 0 0 0.456923077 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Alzheimer disease 0 0 -0.405384615 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood AMPK signaling pathway 0 0 0.46 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Arachidonic acid metabolism 0 0 0.473846154 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Biosynthesis of amino acids 0 0 0.432307692 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Calcium signaling pathway 0.512280702 0 0 serum_phospholipids kegg 0.00872 NA no up up no up up 18:1/20:3-PC+blood Cardiac muscle contraction 0 0 -0.440769231 serum_phospholipids kegg 0.00872 NA no up up no no up 18:1/20:3-PC+blood Cell cycle 0 0 -0.447692308 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Cellular senescence 0.496491228 0 0 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Clostridium 0 0.555487535 0 serum_phospholipids Genus 0.00872 0.925 no up up no no no 18:1/20:3-PC+blood Colorectal cancer 0 0 -0.402307692 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Diabetic cardiomyopathy 0 0 -0.460769231 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Estrogen signaling pathway -0.461403509 0 0 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Ferroptosis 0 0 0.452307692 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Glioma 0 0 -0.420769231 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Glutathione metabolism 0 0 0.467692308 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood "Glycine, serine and threonine metabolism" 0 0 0.404615385 serum_phospholipids kegg 0.00872 NA no up up no up no 18:1/20:3-PC+blood HDCA+stool 0 0 -0.532330827 serum_phospholipids stool_bileacids 0.00872 0.176 no up up no no no 18:1/20:3-PC+blood Inflammatory bowel disease 0.470175439 0 0 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Intestinal immune network for IgA production 0.624561404 0 0 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Kaposi sarcoma-associated herpesvirus infection 0 0.520588235 0.400769231 serum_phospholipids kegg 0.00872 NA no up up no no dn 18:1/20:3-PC+blood Lachnospira 0 0 0.551370671 butyrate-producing serum_phospholipids Genus 0.00872 0.279 no up up no no no 18:1/20:3-PC+blood Long-term potentiation 0 0 -0.512307692 serum_phospholipids kegg 0.00872 NA no up up no no up 18:1/20:3-PC+blood Longevity regulating pathway 0 0 0.433076923 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Malaria 0 0 0.424615385 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood MAPK signaling pathway -0.505263158 0 0 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood nutriCA+stool 0 0.623879467 0 serum_phospholipids stool_bileacids 0.00872 0.481 no up up no no no 18:1/20:3-PC+blood Oocyte meiosis 0 0 -0.569230769 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Oxidative phosphorylation 0 0 -0.424615385 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Peroxisome 0 0 0.437692308 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Phosphatidylinositol signaling system 0 0 -0.523076923 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Porphyrin and chlorophyll metabolism 0 0 0.462307692 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Prevotella -0.588108105 0 0 acetate-producing serum_phospholipids Genus 0.00872 0.287 no up up no no no 18:1/20:3-PC+blood Prion disease 0 0 -0.456153846 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Purine metabolism 0 0 0.434615385 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Ras signaling pathway 0 0 -0.503076923 yes serum_phospholipids kegg 0.00872 NA no up up no up up 18:1/20:3-PC+blood Retrograde endocannabinoid signaling 0 0 -0.556923077 serum_phospholipids kegg 0.00872 NA no up up no no up 18:1/20:3-PC+blood RNA degradation 0 0 -0.464615385 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Th1 and Th2 cell differentiation 0.461403509 0 0 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Thermogenesis 0 0 -0.404615385 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Viral protein interaction with cytokine and cytokine receptor 0.459649123 0 0 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:3-PC+blood Wnt signaling pathway 0 0 -0.551538462 serum_phospholipids kegg 0.00872 NA no up up no no no 18:1/20:4-PC+blood 11-HETE+blood 0 -0.599388039 0 serum_phospholipids serum_ARA 0.582 0.464 no no no no no no 18:1/20:4-PC+blood 14:0-LPC+blood -0.593984962 0 0 serum_phospholipids serum_phospholipids 0.582 0.00689 no no no up up no 18:1/20:4-PC+blood 14:0/18:0-PC+blood 0 -0.75 0 serum_phospholipids serum_phospholipids 0.582 0.00289 no no no up up no 18:1/20:4-PC+blood 16:0-LPC+blood 0 0 -0.658119658 serum_phospholipids serum_phospholipids 0.582 0.00456 no no no up up no 18:1/20:4-PC+blood 16:0/16:0-PI+blood -0.506766917 -0.713235294 0 serum_phospholipids serum_phospholipids 0.582 0.358 no no no no no no 18:1/20:4-PC+blood 16:0/16:1-PC+blood 0 -0.732843137 0 serum_phospholipids serum_phospholipids 0.582 0.00283 no no no up up no 18:1/20:4-PC+blood 16:0/16:1-PI+blood -0.606015038 -0.588235294 0 serum_phospholipids serum_phospholipids 0.582 0.262 no no no no no no 18:1/20:4-PC+blood 16:0/18:1-PC+blood 0.530827068 0 0 serum_phospholipids serum_phospholipids 0.582 6.15E-07 no no no up up up 18:1/20:4-PC+blood 16:0/18:1-PE+blood -0.50075188 -0.730392157 0 serum_phospholipids serum_phospholipids 0.582 0.000107 no no no up up no 18:1/20:4-PC+blood 16:0/18:2-PI+blood -0.697744361 -0.75245098 -0.414017094 serum_phospholipids serum_phospholipids 0.582 0.269 no no no no no no 18:1/20:4-PC+blood 16:0/20:4-PC+blood 0.693233083 0.681372549 0.746324786 serum_phospholipids serum_phospholipids 0.582 0.0262 no no no no up no 18:1/20:4-PC+blood 16:0/20:5-PG+blood 0.765413534 0 0 serum_phospholipids serum_phospholipids 0.582 0.00656 no no no no up no 18:1/20:4-PC+blood 16:0/22:6-PC+blood 0 0.786764706 0 serum_phospholipids serum_phospholipids 0.582 4.53E-05 no no no no up up 18:1/20:4-PC+blood 16:1/16:0-PC+blood 0 0.610294118 0 serum_phospholipids serum_phospholipids 0.582 0.0215 no no no no up up 18:1/20:4-PC+blood 16:1/16:1-PC+blood 0.603007519 0 0 serum_phospholipids serum_phospholipids 0.582 0.0177 no no no no no up 18:1/20:4-PC+blood 16:1/18:1-PG+blood 0.455639098 0 0 serum_phospholipids serum_phospholipids 0.582 3.21E-05 no no no no up up 18:1/20:4-PC+blood 18:0/16:0-PC+blood 0.559398496 0 0 serum_phospholipids serum_phospholipids 0.582 9.64E-07 no no no up up up 18:1/20:4-PC+blood 18:0/18:0-PE+blood 0 -0.732843137 0 serum_phospholipids serum_phospholipids 0.582 0.00896 no no no up up no 18:1/20:4-PC+blood 18:0/18:1-PE+blood 0 -0.732843137 0 serum_phospholipids serum_phospholipids 0.582 0.00716 no no no up up no 18:1/20:4-PC+blood 18:0/18:1-PI+blood 0 -0.546568627 0 serum_phospholipids serum_phospholipids 0.582 0.599 no no no no no no 18:1/20:4-PC+blood 18:0/18:2-PC+blood 0 0 0.401025641 serum_phospholipids serum_phospholipids 0.582 1.74E-06 no no no no up up 18:1/20:4-PC+blood 18:0/20:4-PC+blood 0.839097744 0.892156863 0.871452991 serum_phospholipids serum_phospholipids 0.582 0.454 no no no no no no 18:1/20:4-PC+blood 18:0/20:4-PI+blood 0.491729323 0 0 serum_phospholipids serum_phospholipids 0.582 0.167 no no no no no no 18:1/20:4-PC+blood 18:0/20:5-PC+blood 0 0.909313725 0.656752137 serum_phospholipids serum_phospholipids 0.582 0.17 no no no no no no 18:1/20:4-PC+blood 18:0/22:6-PC+blood 0 0.649509804 0 serum_phospholipids serum_phospholipids 0.582 0.0775 no no no no no up 18:1/20:4-PC+blood 18:1/16:0-PC+blood 0 0 0.412649573 serum_phospholipids serum_phospholipids 0.582 2.43E-05 no no no no up up 18:1/20:4-PC+blood 18:1/16:0-PE+blood 0 -0.720588235 0 serum_phospholipids serum_phospholipids 0.582 0.000182 no no no up up no 18:1/20:4-PC+blood 18:1/16:0-PI+blood 0 -0.671568627 -0.482393162 serum_phospholipids serum_phospholipids 0.582 0.793 no no no no no no 18:1/20:4-PC+blood 18:1/16:1-PE+blood -0.618045113 -0.710784314 0 serum_phospholipids serum_phospholipids 0.582 0.000184 no no no up up no 18:1/20:4-PC+blood 18:1/18:0-PE+blood -0.485714286 -0.779411765 0 serum_phospholipids serum_phospholipids 0.582 1.39E-06 no no no up up no 18:1/20:4-PC+blood 18:1/18:0-PI+blood 0 0 -0.493333333 serum_phospholipids serum_phospholipids 0.582 0.0931 no no no no no up 18:1/20:4-PC+blood 18:1/18:1-PE+blood -0.491729323 -0.68872549 0 serum_phospholipids serum_phospholipids 0.582 1.03E-05 no no no up up no 18:1/20:4-PC+blood 18:1/18:2-PE+blood 0 -0.781862745 0 serum_phospholipids serum_phospholipids 0.582 0.000293 no no no up up no 18:1/20:4-PC+blood 18:1/20:3-PC+blood 0 0 0.481709402 serum_phospholipids serum_phospholipids 0.582 0.00872 no no no no up up 18:1/20:4-PC+blood Aldosterone synthesis and secretion 0 0 -0.441538462 serum_phospholipids kegg 0.582 NA no no no no up up 18:1/20:4-PC+blood Arginine and proline metabolism 0.466666667 0 0 serum_phospholipids kegg 0.582 NA no no no no up no 18:1/20:4-PC+blood Autophagy - animal 0 0 0.413846154 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Axon guidance 0 -0.532352941 0 serum_phospholipids kegg 0.582 NA no no no no up up 18:1/20:4-PC+blood B cell receptor signaling pathway 0.554385965 0 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Biosynthesis of amino acids 0 0 0.424615385 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Biosynthesis of cofactors -0.587719298 0 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Calcium signaling pathway 0 0 -0.461538462 serum_phospholipids kegg 0.582 NA no no no no up up 18:1/20:4-PC+blood Carbon metabolism 0 0 0.567692308 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Cholinergic synapse 0 0.535294118 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Circadian entrainment -0.496491228 0 0 serum_phospholipids kegg 0.582 NA no no no no up up 18:1/20:4-PC+blood Cortisol synthesis and secretion 0 0 -0.42 serum_phospholipids kegg 0.582 NA no no no no no up 18:1/20:4-PC+blood Epithelial cell signaling in Helicobacter pylori infection 0.519298246 0 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Epstein-Barr virus infection 0 -0.502941176 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Estrogen signaling pathway -0.480701754 0 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Gap junction -0.51754386 0 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Glucagon signaling pathway -0.466666667 0 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood "Glycine, serine and threonine metabolism" -0.563157895 0 0 serum_phospholipids kegg 0.582 NA no no no no up no 18:1/20:4-PC+blood Glycolysis / Gluconeogenesis 0 0 0.442307692 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood IL-17 signaling pathway 0.477192982 0 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.647058824 0 serum_phospholipids kegg 0.582 NA no no no no no dn 18:1/20:4-PC+blood Lipid and atherosclerosis 0.477192982 0 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Lysosome 0.49122807 0 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood MAPK signaling pathway 0 0.714705882 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Melanogenesis -0.5 0 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Morphine addiction 0 0 -0.405384615 serum_phospholipids kegg 0.582 NA no no no no up up 18:1/20:4-PC+blood NOD-like receptor signaling pathway 0.522807018 0 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Non-alcoholic fatty liver disease 0 -0.576470588 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Parabacteroides 0 0.556372549 0 serum_phospholipids Genus 0.582 4.19E-05 no no no no up up 18:1/20:4-PC+blood Parkinson disease 0 -0.505882353 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Peroxisome 0 0 0.420769231 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Porphyrin and chlorophyll metabolism -0.464912281 0 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Prevotella -0.611021408 0 0 acetate-producing serum_phospholipids Genus 0.582 0.287 no no no no no no 18:1/20:4-PC+blood Renin secretion -0.587719298 0 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Ruminococcus 0 -0.697731584 0 serum_phospholipids Genus 0.582 0.0679 no no no no no dn 18:1/20:4-PC+blood Shigellosis 0 -0.567647059 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood TCA+stool 0 -0.736363636 0 serum_phospholipids stool_bileacids 0.582 0.458 no no no no no no 18:1/20:4-PC+blood Th1 and Th2 cell differentiation 0.515789474 0 0 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Toll-like receptor signaling pathway 0.478947368 0 0 yes serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PC+blood Vasopressin-regulated water reabsorption 0 0 -0.411538462 serum_phospholipids kegg 0.582 NA no no no no no no 18:1/20:4-PE+blood 12-HEPE+blood -0.539420539 0 0 serum_phospholipids serum_ARA 0.0578 0.312 up no no no no no 18:1/20:4-PE+blood 16:0/18:0-PS+blood 0.781954887 0.700980392 0 serum_phospholipids serum_phospholipids 0.0578 0.377 up no no no no no 18:1/20:4-PE+blood 16:0/18:1-PE+blood 0.454135338 0 0.688205128 serum_phospholipids serum_phospholipids 0.0578 0.000107 up no no up up no 18:1/20:4-PE+blood 16:0/20:4-PE+blood 0.55037594 0.727941176 0.797606838 serum_phospholipids serum_phospholipids 0.0578 0.00139 up no no up up no 18:1/20:4-PE+blood 16:0/22:6-PE+blood 0.801503759 0.87254902 0.74974359 serum_phospholipids serum_phospholipids 0.0578 0.000934 up no no up up no 18:1/20:4-PE+blood 16:1+blood 0 0.661764706 0 yes serum_phospholipids serum_fattyacid 0.0578 0.0186 up no no no no dn 18:1/20:4-PE+blood 18:0/18:0-PE+blood 0 0 0.477606838 serum_phospholipids serum_phospholipids 0.0578 0.00896 up no no up up no 18:1/20:4-PE+blood 18:0/18:0-PS+blood 0.682706767 0.593137255 0 serum_phospholipids serum_phospholipids 0.0578 0.00617 up no no no up no 18:1/20:4-PE+blood 18:0/18:1-PE+blood 0 0 0.498803419 serum_phospholipids serum_phospholipids 0.0578 0.00716 up no no up up no 18:1/20:4-PE+blood 18:0/22:6-PE+blood 0.607518797 0.710784314 0.643760684 serum_phospholipids serum_phospholipids 0.0578 0.00022 up no no up up no 18:1/20:4-PE+blood 18:1/16:0-PE+blood 0.446616541 0.49754902 0.714871795 serum_phospholipids serum_phospholipids 0.0578 0.000182 up no no up up no 18:1/20:4-PE+blood 18:1/16:1-PE+blood 0 0 0.709401709 serum_phospholipids serum_phospholipids 0.0578 0.000184 up no no up up no 18:1/20:4-PE+blood 18:1/18:0-PE+blood 0.587969925 0 0.753162393 serum_phospholipids serum_phospholipids 0.0578 1.39E-06 up no no up up no 18:1/20:4-PE+blood 18:1/18:0-PS+blood 0.47518797 0.487745098 0 serum_phospholipids serum_phospholipids 0.0578 0.193 up no no no no no 18:1/20:4-PE+blood 18:1/18:1-PE+blood 0.628571429 0.487745098 0.739487179 serum_phospholipids serum_phospholipids 0.0578 1.03E-05 up no no up up no 18:1/20:4-PE+blood 18:1/18:2-PE+blood 0.577443609 0 0.697777778 serum_phospholipids serum_phospholipids 0.0578 0.000293 up no no up up no 18:1/20:4-PI+blood "12,13-EPOME+blood" 0 0 -0.516284083 serum_phospholipids serum_ARA 0.192 0.901 no no no no no no 18:1/20:4-PI+blood 16:0/14:0-PC+blood 0 -0.615196078 0 serum_phospholipids serum_phospholipids 0.192 0.0206 no no no no up up 18:1/20:4-PI+blood 16:0/16:0-PC+blood 0 -0.531862745 0 serum_phospholipids serum_phospholipids 0.192 0.00079 no no no no up up 18:1/20:4-PI+blood 16:0/20:4-PC+blood 0 0 0.597264957 serum_phospholipids serum_phospholipids 0.192 0.0262 no no no no up no 18:1/20:4-PI+blood 16:1/18:1-PG+blood 0 0 -0.417435897 serum_phospholipids serum_phospholipids 0.192 3.21E-05 no no no no up up 18:1/20:4-PI+blood 16:1/18:2-PG+blood 0 0 -0.404444444 serum_phospholipids serum_phospholipids 0.192 1.40E-08 no no no no up up 18:1/20:4-PI+blood 18:0/20:4-PC+blood 0 0 0.665641026 serum_phospholipids serum_phospholipids 0.192 0.454 no no no no no no 18:1/20:4-PI+blood 18:0/20:4-PI+blood 0 0.541666667 0 serum_phospholipids serum_phospholipids 0.192 0.167 no no no no no no 18:1/20:4-PI+blood 18:0/20:5-PC+blood 0 0 0.445470085 serum_phospholipids serum_phospholipids 0.192 0.17 no no no no no no 18:1/20:4-PI+blood 18:0+blood 0 0 0.456410256 serum_phospholipids serum_fattyacid 0.192 0.344 no no no no no no 18:1/20:4-PI+blood 18:1/18:2-PI+blood 0.57443609 0.544117647 0 serum_phospholipids serum_phospholipids 0.192 0.0164 no no no dn no up 18:1/20:4-PI+blood 18:1/20:3-PC+blood 0 0 0.475555556 serum_phospholipids serum_phospholipids 0.192 0.00872 no no no no up up 18:1/20:4-PI+blood 18:1/20:4-PC+blood 0 0 0.494017094 serum_phospholipids serum_phospholipids 0.192 0.582 no no no no no no 18:1/20:4-PI+blood 18:1+blood 0 0.674019608 0 yes serum_phospholipids serum_fattyacid 0.192 0.00202 no no no up no dn 18:1/22:6-PE+blood 12-ketoDCA+blood 0 -0.576306805 0 serum_phospholipids serum_bileacids 0.0047 0.517 no up no no no no 18:1/22:6-PE+blood 14:0-LPC+blood -0.512781955 0 -0.461880342 serum_phospholipids serum_phospholipids 0.0047 0.00689 no up no up up no 18:1/22:6-PE+blood 14:0/18:0-PC+blood -0.484210526 0 0 serum_phospholipids serum_phospholipids 0.0047 0.00289 no up no up up no 18:1/22:6-PE+blood 14:0/18:2-PC+blood 0 0 -0.446153846 serum_phospholipids serum_phospholipids 0.0047 0.102 no up no no up no 18:1/22:6-PE+blood 14:1/18:2-PG+blood 0 0 -0.488547009 serum_phospholipids serum_phospholipids 0.0047 0.00259 no up no no up up 18:1/22:6-PE+blood 16:0/16:0-PI+blood 0 0 -0.403760684 serum_phospholipids serum_phospholipids 0.0047 0.358 no up no no no no 18:1/22:6-PE+blood 16:0/16:1-PC+blood -0.490225564 0 0 serum_phospholipids serum_phospholipids 0.0047 0.00283 no up no up up no 18:1/22:6-PE+blood 16:0/16:1-PI+blood 0 0 -0.424957265 serum_phospholipids serum_phospholipids 0.0047 0.262 no up no no no no 18:1/22:6-PE+blood 16:0/18:0-PS+blood 0.587969925 0.595588235 0 serum_phospholipids serum_phospholipids 0.0047 0.377 no up no no no no 18:1/22:6-PE+blood 16:0/18:2-PI+blood 0 0 -0.481025641 serum_phospholipids serum_phospholipids 0.0047 0.269 no up no no no no 18:1/22:6-PE+blood 16:0/20:4-PE+blood 0.50075188 0 0 serum_phospholipids serum_phospholipids 0.0047 0.00139 no up no up up no 18:1/22:6-PE+blood 16:0/22:0-PE+blood 0 0 0.495384615 serum_phospholipids serum_phospholipids 0.0047 0.00839 no up no dn no up 18:1/22:6-PE+blood 16:0/22:6-PC+blood 0 0 0.680683761 serum_phospholipids serum_phospholipids 0.0047 4.53E-05 no up no no up up 18:1/22:6-PE+blood 16:0/22:6-PE+blood 0.729323308 0.620098039 0.493333333 serum_phospholipids serum_phospholipids 0.0047 0.000934 no up no up up no 18:1/22:6-PE+blood 16:1/16:0-PC+blood 0 0.487745098 0.423589744 serum_phospholipids serum_phospholipids 0.0047 0.0215 no up no no up up 18:1/22:6-PE+blood 16:1+blood 0 0.651960784 0 yes serum_phospholipids serum_fattyacid 0.0047 0.0186 no up no no no dn 18:1/22:6-PE+blood 18:0/18:0-PS+blood 0.478195489 0 0 serum_phospholipids serum_phospholipids 0.0047 0.00617 no up no no up no 18:1/22:6-PE+blood 18:0/18:2-PI+blood 0 0 -0.472136752 serum_phospholipids serum_phospholipids 0.0047 0.179 no up no no no no 18:1/22:6-PE+blood 18:0/22:6-PC+blood 0 0.642156863 0.530940171 serum_phospholipids serum_phospholipids 0.0047 0.0775 no up no no no up 18:1/22:6-PE+blood 18:0/22:6-PE+blood 0.666165414 0.75245098 0.662222222 serum_phospholipids serum_phospholipids 0.0047 0.00022 no up no up up no 18:1/22:6-PE+blood 18:0/22:6-PI+blood 0 0.769607843 0 serum_phospholipids serum_phospholipids 0.0047 0.425 no up no no no no 18:1/22:6-PE+blood 18:1/18:0-PE+blood 0.49924812 0 0 serum_phospholipids serum_phospholipids 0.0047 1.39E-06 no up no up up no 18:1/22:6-PE+blood 18:1/18:0-PI+blood 0 0 -0.437264957 serum_phospholipids serum_phospholipids 0.0047 0.0931 no up no no no up 18:1/22:6-PE+blood 18:1/18:0-PS+blood 0 0.62745098 0.415384615 serum_phospholipids serum_phospholipids 0.0047 0.193 no up no no no no 18:1/22:6-PE+blood 18:1/18:1-PE+blood 0.44962406 0 0 serum_phospholipids serum_phospholipids 0.0047 1.03E-05 no up no up up no 18:1/22:6-PE+blood 18:1/18:2-PE+blood 0.472180451 0 0 serum_phospholipids serum_phospholipids 0.0047 0.000293 no up no up up no 18:1/22:6-PE+blood 18:1/20:4-PE+blood 0.8 0.558823529 0 serum_phospholipids serum_phospholipids 0.0047 0.0578 no up no up no no 18:1/22:6-PE+blood 18:1+blood 0 0.558823529 0 yes serum_phospholipids serum_fattyacid 0.0047 0.00202 no up no up no dn 18:1+blood 12-ketoDCA+blood -0.460321511 -0.536788624 0 yes serum_fattyacid serum_bileacids 0.00202 0.517 up no dn no no no 18:1+blood "12,13-EPOME+blood" 0.463509693 0 0 yes serum_fattyacid serum_ARA 0.00202 0.901 up no dn no no no 18:1+blood 13-HODE+blood 0.481203008 0 0 yes serum_fattyacid serum_ARA 0.00202 0.32 up no dn no no no 18:1+blood 14:0+blood 0 0.50245098 0 yes yes serum_fattyacid serum_fattyacid 0.00202 0.00572 up no dn up no dn 18:1+blood 14:1/18:2-PG+blood -0.470676692 0 0 yes serum_fattyacid serum_phospholipids 0.00202 0.00259 up no dn no up up 18:1+blood 16:0/18:1-PC+blood 0 0 0.591111111 yes serum_fattyacid serum_phospholipids 0.00202 6.15E-07 up no dn up up up 18:1+blood 16:0/20:4-PE+blood 0 0 0.419487179 yes serum_fattyacid serum_phospholipids 0.00202 0.00139 up no dn up up no 18:1+blood 16:0/20:5-PG+blood 0 0 -0.402393162 yes serum_fattyacid serum_phospholipids 0.00202 0.00656 up no dn no up no 18:1+blood 16:0+blood 0.772932331 0.495098039 0.554871795 yes yes serum_fattyacid serum_fattyacid 0.00202 0.00876 up no dn up no no 18:1+blood 16:1/18:2-PG+blood 0 0 -0.423589744 yes serum_fattyacid serum_phospholipids 0.00202 1.40E-08 up no dn no up up 18:1+blood 16:1+blood 0.828571429 0.568627451 0.578803419 yes yes serum_fattyacid serum_fattyacid 0.00202 0.0186 up no dn no no dn 18:1+blood 18:0/16:0-PC+blood 0 0 0.567179487 yes serum_fattyacid serum_phospholipids 0.00202 9.64E-07 up no dn up up up 18:1+blood 18:0/20:2-PC+blood 0 -0.605392157 0 yes serum_fattyacid serum_phospholipids 0.00202 0.733 up no dn no no no 18:1+blood 18:0/20:3-PI+blood 0.551879699 0 0 yes serum_fattyacid serum_phospholipids 0.00202 0.377 up no dn no no no 18:1+blood 18:0/20:4-PI+blood 0.54887218 0 0 yes serum_fattyacid serum_phospholipids 0.00202 0.167 up no dn no no no 18:1+blood 18:0+blood 0.654135338 0 0 yes serum_fattyacid serum_fattyacid 0.00202 0.344 up no dn no no no 18:1+blood AGE-RAGE signaling pathway in diabetic complications 0.626315789 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Alcoholism 0 0.517647059 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood AMPK signaling pathway -0.456140351 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Antigen processing and presentation 0 0 0.443076923 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Arginine and proline metabolism 0 0 0.475384615 yes serum_fattyacid kegg 0.00202 NA up no dn no up no 18:1+blood Bifidobacterium 0 -0.49049672 0 yes acetate-producing serum_fattyacid Genus 0.00202 0.105 up no dn no dn no 18:1+blood Biosynthesis of amino acids 0 0 0.459230769 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Biosynthesis of cofactors -0.680701754 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Calcium signaling pathway 0 -0.602941176 0 yes serum_fattyacid kegg 0.00202 NA up no dn no up up 18:1+blood Carbon metabolism 0 0 0.499230769 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood cGMP-PKG signaling pathway 0.628070175 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Cholinergic synapse 0.552631579 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Cushing syndrome 0 0 -0.416153846 yes serum_fattyacid kegg 0.00202 NA up no dn no no up 18:1+blood Cytokine-cytokine receptor interaction 0.456140351 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Epithelial cell signaling in Helicobacter pylori infection 0 0 0.427692308 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Fc epsilon RI signaling pathway 0.457894737 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Fc gamma R-mediated phagocytosis 0 0 0.564615385 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood FoxO signaling pathway 0.470175439 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood GABAergic synapse 0.568421053 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no up up 18:1+blood Glioma 0.635087719 0.541176471 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Glucagon signaling pathway 0 0 -0.402307692 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood "Glycine, serine and threonine metabolism" -0.596491228 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no up no 18:1+blood HCA+stool 0.620879121 0 -0.44962406 yes serum_fattyacid stool_bileacids 0.00202 0.155 up no dn no no no 18:1+blood IL-17 signaling pathway 0 0 0.443846154 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Inflammatory bowel disease 0.477192982 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Leishmaniasis 0 0 0.472307692 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Lipid and atherosclerosis 0.671929825 0 0.62 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Long-term potentiation 0.501754386 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no up 18:1+blood Lysosome 0 0 0.406923077 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Mineral absorption 0 -0.517647059 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Mitophagy - animal -0.470175439 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood mRNA surveillance pathway 0 0 -0.423846154 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Neutrophil extracellular trap formation 0 0 0.420769231 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood NOD-like receptor signaling pathway 0.561403509 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Olfactory transduction 0.557894737 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Osteoclast differentiation 0 0 0.495384615 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Peroxisome 0.494736842 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Pertussis 0.584210526 0 0.531538462 yes serum_fattyacid kegg 0.00202 NA up no dn no no dn 18:1+blood Phagosome 0 0 0.486153846 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Porphyrin and chlorophyll metabolism -0.601754386 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood PPAR signaling pathway 0 0 0.476153846 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Prolactin signaling pathway 0.496491228 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Proteoglycans in cancer -0.647368421 -0.555882353 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Ras signaling pathway 0 0 -0.412307692 yes yes serum_fattyacid kegg 0.00202 NA up no dn no up up 18:1+blood Rheumatoid arthritis 0 0 0.433076923 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Salivary secretion 0 0.514705882 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Shigellosis -0.557894737 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Sphingolipid signaling pathway 0.6 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Staphylococcus aureus infection 0 0 0.654615385 yes serum_fattyacid kegg 0.00202 NA up no dn up no no 18:1+blood Systemic lupus erythematosus 0 0 0.627692308 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Toll-like receptor signaling pathway 0 0 0.416923077 yes yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Toxoplasmosis 0 0 0.515384615 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood Tuberculosis 0.468421053 0 0.527692308 yes serum_fattyacid kegg 0.00202 NA up no dn no no dn 18:1+blood Ubiquitin mediated proteolysis -0.480701754 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:1+blood VEGF signaling pathway 0.559649123 0 0 yes serum_fattyacid kegg 0.00202 NA up no dn no no no 18:2-LPA+blood 13-HODE+blood 0.512781955 0 0 serum_phospholipids serum_ARA 0.00684 0.32 dn no up no no no 18:2-LPA+blood 14:0/18:2-PC+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.00684 0.102 dn no up no up no 18:2-LPA+blood 16:0-LPE+blood -0.580451128 0 0 serum_phospholipids serum_phospholipids 0.00684 0.0711 dn no up up up no 18:2-LPA+blood 16:0/14:0-PC+blood 0.544360902 0 0 serum_phospholipids serum_phospholipids 0.00684 0.0206 dn no up no up up 18:2-LPA+blood 16:0/18:0-PS+blood 0 -0.49754902 0 serum_phospholipids serum_phospholipids 0.00684 0.377 dn no up no no no 18:2-LPA+blood 16:0/18:1-PC+blood 0.45112782 0 0 serum_phospholipids serum_phospholipids 0.00684 6.15E-07 dn no up up up up 18:2-LPA+blood 16:0/20:3-PC+blood 0.479699248 0 0 serum_phospholipids serum_phospholipids 0.00684 5.43E-06 dn no up no up up 18:2-LPA+blood 16:0/20:4-PC+blood 0.551879699 0 0 serum_phospholipids serum_phospholipids 0.00684 0.0262 dn no up no up no 18:2-LPA+blood 16:0/20:5-PC+blood 0 -0.539215686 0 serum_phospholipids serum_phospholipids 0.00684 0.628 dn no up no no no 18:2-LPA+blood 16:1/16:0-PC+blood 0.533834586 0 0 serum_phospholipids serum_phospholipids 0.00684 0.0215 dn no up no up up 18:2-LPA+blood 16:1/16:1-PC+blood 0.560902256 0 0 serum_phospholipids serum_phospholipids 0.00684 0.0177 dn no up no no up 18:2-LPA+blood 18:0/16:0-PC+blood 0.461654135 0 0 serum_phospholipids serum_phospholipids 0.00684 9.64E-07 dn no up up up up 18:2-LPA+blood 18:0/18:0-PS+blood 0 -0.595588235 0 serum_phospholipids serum_phospholipids 0.00684 0.00617 dn no up no up no 18:2-LPA+blood 18:0/20:4-PC+blood 0.515789474 0 0 serum_phospholipids serum_phospholipids 0.00684 0.454 dn no up no no no 18:2-LPA+blood 18:0/22:6-PC+blood 0 -0.526960784 0 serum_phospholipids serum_phospholipids 0.00684 0.0775 dn no up no no up 18:2-LPA+blood 18:0/22:6-PE+blood 0 -0.580882353 -0.45982906 serum_phospholipids serum_phospholipids 0.00684 0.00022 dn no up up up no 18:2-LPA+blood 18:0/22:6-PI+blood 0 -0.485294118 0 serum_phospholipids serum_phospholipids 0.00684 0.425 dn no up no no no 18:2-LPA+blood 18:1/18:0-PS+blood 0 -0.610294118 -0.431794872 serum_phospholipids serum_phospholipids 0.00684 0.193 dn no up no no no 18:2-LPA+blood 18:1/18:1-PC+blood 0.551879699 0 0 serum_phospholipids serum_phospholipids 0.00684 1.34E-05 dn no up no up up 18:2-LPA+blood 18:1/18:2-PE+blood -0.541353383 0 0 serum_phospholipids serum_phospholipids 0.00684 0.000293 dn no up up up no 18:2-LPA+blood 18:1/22:6-PE+blood -0.497744361 0 0 serum_phospholipids serum_phospholipids 0.00684 0.0047 dn no up no up no 18:2-LPA+blood DCA+stool 0 0 -0.610526316 serum_phospholipids stool_bileacids 0.00684 0.195 dn no up no no no 18:2-LPA+blood HDCA+stool 0.565934066 0 0 serum_phospholipids stool_bileacids 0.00684 0.176 dn no up no no no 18:2-LPA+blood LCA+stool 0.752747253 0 -0.679699248 serum_phospholipids stool_bileacids 0.00684 0.314 dn no up no no no 18:2-LPA+blood Pancreatic cancer 0 0 -0.452307692 serum_phospholipids kegg 0.00684 NA dn no up no no no 18:2-LPA+blood Propionic acid+stool 0 0 -0.553383459 yes serum_phospholipids stool_scfa 0.00684 0.0436 dn no up dn no up 18:2-LPA+blood Protein processing in endoplasmic reticulum 0 0 -0.423846154 serum_phospholipids kegg 0.00684 NA dn no up no no no 18:2-LPA+blood Renal cell carcinoma 0 0 -0.418461538 serum_phospholipids kegg 0.00684 NA dn no up no no no 18:2-LPA+blood Ruminococcus 0.584962406 0 0 acetate-producing serum_phospholipids Genus 0.00684 0.335 dn no up no no no 18:2-LPA+blood Th1 and Th2 cell differentiation 0 0 0.441538462 serum_phospholipids kegg 0.00684 NA dn no up no no no 18:2-LPA+blood Th17 cell differentiation 0 0 0.400769231 serum_phospholipids kegg 0.00684 NA dn no up no no no 18:2-LPC+blood 13-HODE+blood 0 0.507352941 0 serum_phospholipids serum_ARA 0.00743 0.32 dn no up no no no 18:2-LPC+blood 14:0/16:0-PC+blood 0 0 -0.416752137 serum_phospholipids serum_phospholipids 0.00743 0.0358 dn no up no up no 18:2-LPC+blood 14:0/20:4-PC+blood -0.562406015 0 0 serum_phospholipids serum_phospholipids 0.00743 0.486 dn no up no no no 18:2-LPC+blood 16:0/16:0-PI+blood 0 0 -0.502222222 serum_phospholipids serum_phospholipids 0.00743 0.358 dn no up no no no 18:2-LPC+blood 16:0/16:1-PI+blood 0 0 -0.433162393 serum_phospholipids serum_phospholipids 0.00743 0.262 dn no up no no no 18:2-LPC+blood 16:0/18:0-PS+blood 0 0 -0.534358974 serum_phospholipids serum_phospholipids 0.00743 0.377 dn no up no no no 18:2-LPC+blood 16:0/18:1-PE+blood 0 0 -0.515213675 serum_phospholipids serum_phospholipids 0.00743 0.000107 dn no up up up no 18:2-LPC+blood 16:0/20:4-PE+blood 0 0 -0.483760684 serum_phospholipids serum_phospholipids 0.00743 0.00139 dn no up up up no 18:2-LPC+blood 16:0/20:4-PI+blood 0 -0.526960784 -0.446153846 serum_phospholipids serum_phospholipids 0.00743 0.558 dn no up no no no 18:2-LPC+blood 16:0/20:5-PC+blood -0.57443609 0 0 serum_phospholipids serum_phospholipids 0.00743 0.628 dn no up no no no 18:2-LPC+blood 16:0/22:6-PE+blood 0 0 -0.472820513 serum_phospholipids serum_phospholipids 0.00743 0.000934 dn no up up up no 18:2-LPC+blood 16:0+blood 0 0 -0.474188034 yes serum_phospholipids serum_fattyacid 0.00743 0.00876 dn no up up no no 18:2-LPC+blood 16:1+blood 0 0 -0.42974359 yes serum_phospholipids serum_fattyacid 0.00743 0.0186 dn no up no no dn 18:2-LPC+blood 18:0-LPC+blood 0 0 0.484444444 serum_phospholipids serum_phospholipids 0.00743 0.554 dn no up no no no 18:2-LPC+blood 18:0/18:0-PC+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.00743 0.426 dn no up no no no 18:2-LPC+blood 18:0/18:0-PS+blood -0.44962406 0 -0.525470085 serum_phospholipids serum_phospholipids 0.00743 0.00617 dn no up no up no 18:2-LPC+blood 18:0/18:1-PC+blood 0 -0.539215686 0 serum_phospholipids serum_phospholipids 0.00743 0.393 dn no up no no no 18:2-LPC+blood 18:0/18:1-PG+blood 0 -0.482843137 -0.586324786 serum_phospholipids serum_phospholipids 0.00743 0.000842 dn no up no up no 18:2-LPC+blood 18:0/18:2-PC+blood 0.454135338 0 0 serum_phospholipids serum_phospholipids 0.00743 1.74E-06 dn no up no up up 18:2-LPC+blood 18:0/20:2-PC+blood 0 -0.482843137 0.416752137 serum_phospholipids serum_phospholipids 0.00743 0.733 dn no up no no no 18:2-LPC+blood 18:0/20:3-PC+blood 0 -0.629901961 0 serum_phospholipids serum_phospholipids 0.00743 0.0682 dn no up no up no 18:2-LPC+blood 18:0/20:4-PI+blood 0 0 -0.496752137 serum_phospholipids serum_phospholipids 0.00743 0.167 dn no up no no no 18:2-LPC+blood 18:0/22:6-PC+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 0.00743 0.0775 dn no up no no up 18:2-LPC+blood 18:0/22:6-PE+blood 0 0 -0.522735043 serum_phospholipids serum_phospholipids 0.00743 0.00022 dn no up up up no 18:2-LPC+blood 18:0/22:6-PI+blood 0 -0.62254902 -0.433162393 serum_phospholipids serum_phospholipids 0.00743 0.425 dn no up no no no 18:2-LPC+blood 18:1-LPC+blood 0.661654135 0 0.79965812 serum_phospholipids serum_phospholipids 0.00743 0.179 dn no up no no no 18:2-LPC+blood 18:1-LPE+blood 0 0 0.676581197 serum_phospholipids serum_phospholipids 0.00743 0.117 dn no up no no no 18:2-LPC+blood 18:1/16:1-PE+blood 0 0 -0.518632479 serum_phospholipids serum_phospholipids 0.00743 0.000184 dn no up up up no 18:2-LPC+blood 18:1/18:1-PI+blood 0.509774436 0 0 serum_phospholipids serum_phospholipids 0.00743 0.111 dn no up dn no no 18:2-LPC+blood 18:1/18:2-PI+blood 0 0 0.452991453 serum_phospholipids serum_phospholipids 0.00743 0.0164 dn no up dn no up 18:2-LPC+blood 18:1/22:6-PE+blood 0 -0.529411765 0 serum_phospholipids serum_phospholipids 0.00743 0.0047 dn no up no up no 18:2-LPC+blood Adlercreutzia 0 0 0.50770783 serum_phospholipids Genus 0.00743 0.548 dn no up no no no 18:2-LPC+blood Arginine and proline metabolism 0 0 -0.637692308 serum_phospholipids kegg 0.00743 NA dn no up no up no 18:2-LPC+blood Blautia -0.487218045 0 0 acetate-producing serum_phospholipids Genus 0.00743 1.36E-05 dn no up up dn dn 18:2-LPC+blood Butyricicoccus -0.455234657 0 0 butyrate-producing serum_phospholipids Genus 0.00743 0.852 dn no up no no no 18:2-LPC+blood Clostridium 0 -0.638871978 0 serum_phospholipids Genus 0.00743 0.925 dn no up no no no 18:2-LPC+blood Collinsella -0.58132596 0 0 serum_phospholipids Genus 0.00743 0.128 dn no up no no no 18:2-LPC+blood Coprococcus -0.578947368 0 0 butyrate-producing serum_phospholipids Genus 0.00743 0.612 dn no up no no no 18:2-LPC+blood Cytosolic DNA-sensing pathway 0 0 -0.414615385 serum_phospholipids kegg 0.00743 NA dn no up no no no 18:2-LPC+blood Dorea -0.532330827 0 0 serum_phospholipids Genus 0.00743 0.00362 dn no up up no dn 18:2-LPC+blood Epithelial cell signaling in Helicobacter pylori infection 0 0 -0.401538462 serum_phospholipids kegg 0.00743 NA dn no up no no no 18:2-LPC+blood FoxO signaling pathway 0 0 0.434615385 serum_phospholipids kegg 0.00743 NA dn no up no no no 18:2-LPC+blood HDCA+stool 0 0 -0.470676692 serum_phospholipids stool_bileacids 0.00743 0.176 dn no up no no no 18:2-LPC+blood Hematopoietic cell lineage 0 0 0.416153846 serum_phospholipids kegg 0.00743 NA dn no up no no no 18:2-LPC+blood Measles 0 0 -0.463076923 serum_phospholipids kegg 0.00743 NA dn no up no no no 18:2-LPC+blood Necroptosis 0 0.573529412 0 serum_phospholipids kegg 0.00743 NA dn no up no no no 18:2-LPC+blood nutriCA+stool 0 -0.84407222 0 serum_phospholipids stool_bileacids 0.00743 0.481 dn no up no no no 18:2-LPC+blood Osteoclast differentiation 0 0 -0.427692308 serum_phospholipids kegg 0.00743 NA dn no up no no no 18:2-LPC+blood Platinum drug resistance 0 0 0.481538462 serum_phospholipids kegg 0.00743 NA dn no up no no no 18:2-LPC+blood PPAR signaling pathway 0 0 -0.528461538 serum_phospholipids kegg 0.00743 NA dn no up no no no 18:2-LPC+blood Primary immunodeficiency 0 0 0.403076923 serum_phospholipids kegg 0.00743 NA dn no up no no no 18:2-LPC+blood Prolactin signaling pathway 0 0 -0.400769231 serum_phospholipids kegg 0.00743 NA dn no up no no no 18:2-LPC+blood Purine metabolism 0 0 -0.503076923 serum_phospholipids kegg 0.00743 NA dn no up no no no 18:2-LPC+blood Ras signaling pathway 0 0 0.401538462 yes serum_phospholipids kegg 0.00743 NA dn no up no up up 18:2-LPC+blood Ruminococcus 0 0 -0.404161329 serum_phospholipids Genus 0.00743 0.0679 dn no up no no dn 18:2-LPC+blood TCA+stool -0.624484772 0 0 serum_phospholipids stool_bileacids 0.00743 0.458 dn no up no no no 18:2-LPC+blood Toll-like receptor signaling pathway 0 0 -0.430769231 yes serum_phospholipids kegg 0.00743 NA dn no up no no no 18:2-LPE+blood 13-HODE+blood 0 0.571078431 0 serum_phospholipids serum_ARA 0.112 0.32 no no no no no no 18:2-LPE+blood 16:0/18:0-PS+blood 0 -0.5 0 serum_phospholipids serum_phospholipids 0.112 0.377 no no no no no no 18:2-LPE+blood 16:0/20:5-PC+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.112 0.628 no no no no no no 18:2-LPE+blood 16:0/20:5-PG+blood -0.559398496 0 0 serum_phospholipids serum_phospholipids 0.112 0.00656 no no no no up no 18:2-LPE+blood 16:0/22:0-PE+blood 0 -0.517156863 0 serum_phospholipids serum_phospholipids 0.112 0.00839 no no no dn no up 18:2-LPE+blood 16:1-LPC+blood 0.488721805 0 0 serum_phospholipids serum_phospholipids 0.112 0.0241 no no no no up no 18:2-LPE+blood 18:0-LPC+blood 0 0 0.424273504 serum_phospholipids serum_phospholipids 0.112 0.554 no no no no no no 18:2-LPE+blood 18:0-LPE+blood 0 0 0.484444444 serum_phospholipids serum_phospholipids 0.112 0.491 no no no no no no 18:2-LPE+blood 18:0/18:0-PS+blood -0.505263158 0 0 serum_phospholipids serum_phospholipids 0.112 0.00617 no no no no up no 18:2-LPE+blood 18:0/20:5-PC+blood 0 -0.556372549 0 serum_phospholipids serum_phospholipids 0.112 0.17 no no no no no no 18:2-LPE+blood 18:0/22:6-PC+blood 0 -0.607843137 0 serum_phospholipids serum_phospholipids 0.112 0.0775 no no no no no up 18:2-LPE+blood 18:0/22:6-PE+blood 0 -0.605392157 0 serum_phospholipids serum_phospholipids 0.112 0.00022 no no no up up no 18:2-LPE+blood 18:0/22:6-PI+blood 0 -0.654411765 0 serum_phospholipids serum_phospholipids 0.112 0.425 no no no no no no 18:2-LPE+blood 18:1-LPC+blood 0 0 0.582222222 serum_phospholipids serum_phospholipids 0.112 0.179 no no no no no no 18:2-LPE+blood 18:1-LPE+blood 0.690225564 0.519607843 0.762735043 serum_phospholipids serum_phospholipids 0.112 0.117 no no no no no no 18:2-LPE+blood 18:1/18:0-PI+blood 0 0 0.463247863 serum_phospholipids serum_phospholipids 0.112 0.0931 no no no no no up 18:2-LPE+blood 18:1/18:0-PS+blood -0.446616541 0 0 serum_phospholipids serum_phospholipids 0.112 0.193 no no no no no no 18:2-LPE+blood 18:1/20:4-PC+blood -0.503759398 -0.49754902 -0.407863248 serum_phospholipids serum_phospholipids 0.112 0.582 no no no no no no 18:2-LPE+blood 18:2-LPA+blood 0 0.524509804 0 serum_phospholipids serum_phospholipids 0.112 0.00684 no no no dn no up 18:2-LPE+blood 18:2-LPC+blood 0.619548872 0.512254902 0.676581197 serum_phospholipids serum_phospholipids 0.112 0.00743 no no no dn no up 18:2-LPE+blood 4-hydroxybenzoic acid+stool 0 0 0.556390977 serum_phospholipids stool_cometabolism 0.112 0.0536 no no no no dn no 18:2-LPE+blood Arginine and proline metabolism 0 0 -0.413076923 serum_phospholipids kegg 0.112 NA no no no no up no 18:2-LPE+blood Axon guidance 0 0 0.448461538 serum_phospholipids kegg 0.112 NA no no no no up up 18:2-LPE+blood Bifidobacterium -0.506205376 0 0 acetate-producing serum_phospholipids Genus 0.112 0.105 no no no no dn no 18:2-LPE+blood Blautia -0.57443609 0 0 acetate-producing serum_phospholipids Genus 0.112 1.36E-05 no no no up dn dn 18:2-LPE+blood CDCA+stool 0 0 0.47518797 serum_phospholipids stool_bileacids 0.112 0.663 no no no no no no 18:2-LPE+blood Cell cycle 0 0 0.410769231 serum_phospholipids kegg 0.112 NA no no no no no no 18:2-LPE+blood Chagas disease 0.471929825 0 0 serum_phospholipids kegg 0.112 NA no no no no no no 18:2-LPE+blood Chronic myeloid leukemia 0.505263158 0 0 serum_phospholipids kegg 0.112 NA no no no no no no 18:2-LPE+blood Clostridium -0.446515883 0 0 serum_phospholipids Genus 0.112 0.925 no no no no no no 18:2-LPE+blood Coprococcus -0.493233083 0 0 butyrate-producing serum_phospholipids Genus 0.112 0.612 no no no no no no 18:2-LPE+blood ErbB signaling pathway 0.505263158 0 0 serum_phospholipids kegg 0.112 NA no no no no no no 18:2-LPE+blood Gastric cancer 0 0 0.408461538 serum_phospholipids kegg 0.112 NA no no no no no no 18:2-LPE+blood Gemmiger 0 0 -0.494521273 butyrate-producing serum_phospholipids Genus 0.112 0.595 no no no no no no 18:2-LPE+blood Glutathione metabolism 0 0 -0.400769231 serum_phospholipids kegg 0.112 NA no no no no no no 18:2-LPE+blood L-Phenylalanine+stool 0 0 -0.557894737 serum_phospholipids stool_cometabolism 0.112 0.398 no no no no no no 18:2-LPE+blood L-Tryptophan+stool 0 0 -0.609022556 serum_phospholipids stool_cometabolism 0.112 0.557 no no no no no no 18:2-LPE+blood L-Tyrosine+stool 0 0 -0.460150376 serum_phospholipids stool_cometabolism 0.112 0.44 no no no no no no 18:2-LPE+blood Long-term potentiation 0 0 0.412307692 serum_phospholipids kegg 0.112 NA no no no no no up 18:2-LPE+blood Longevity regulating pathway 0.521052632 0 0 serum_phospholipids kegg 0.112 NA no no no no no no 18:2-LPE+blood Mitophagy - animal 0.461403509 0 0 serum_phospholipids kegg 0.112 NA no no no no no no 18:2-LPE+blood Oscillospira 0 0 -0.502222222 LPS-producing serum_phospholipids Genus 0.112 0.62 no no no no no no 18:2-LPE+blood Peroxisome 0 0 -0.46 serum_phospholipids kegg 0.112 NA no no no no no no 18:2-LPE+blood Phenylacetic acid+stool 0 0 -0.682706767 serum_phospholipids stool_cometabolism 0.112 0.785 no no no no no no 18:2-LPE+blood Prostate cancer 0.463157895 0 0 serum_phospholipids kegg 0.112 NA no no no no no no 18:2-LPE+blood Purine metabolism 0 0 -0.510769231 serum_phospholipids kegg 0.112 NA no no no no no no 18:2-LPE+blood Relaxin signaling pathway 0.49122807 0 0 serum_phospholipids kegg 0.112 NA no no no no no no 18:2-LPE+blood Renal cell carcinoma 0.512280702 0 0 serum_phospholipids kegg 0.112 NA no no no no no no 18:2-LPE+blood Retrograde endocannabinoid signaling 0 0 0.412307692 serum_phospholipids kegg 0.112 NA no no no no no up 18:2-LPE+blood Signaling pathways regulating pluripotency of stem cells 0 0 0.426923077 serum_phospholipids kegg 0.112 NA no no no no no no 18:2/16:0-PC+blood 12-ketoDCA+blood -0.448490818 0 0 serum_phospholipids serum_bileacids 8.67E-05 0.517 no up up no no no 18:2/16:0-PC+blood 13-HODE+blood 0 0.519607843 0 serum_phospholipids serum_ARA 8.67E-05 0.32 no up up no no no 18:2/16:0-PC+blood 16:0-LPE+blood -0.461654135 0 0 serum_phospholipids serum_phospholipids 8.67E-05 0.0711 no up up up up no 18:2/16:0-PC+blood 16:0/14:0-PC+blood 0.663157895 0.539215686 0.697094017 serum_phospholipids serum_phospholipids 8.67E-05 0.0206 no up up no up up 18:2/16:0-PC+blood 16:0/16:0-PC+blood 0.732330827 0 0.64991453 serum_phospholipids serum_phospholipids 8.67E-05 0.00079 no up up no up up 18:2/16:0-PC+blood 16:0/16:0-PI+blood -0.512781955 -0.490196078 0 serum_phospholipids serum_phospholipids 8.67E-05 0.358 no up up no no no 18:2/16:0-PC+blood 16:0/16:1-PI+blood -0.747368421 -0.632352941 0 serum_phospholipids serum_phospholipids 8.67E-05 0.262 no up up no no no 18:2/16:0-PC+blood 16:0/18:0-PC+blood 0.509774436 0 0.574700855 serum_phospholipids serum_phospholipids 8.67E-05 0.521 no up up no no no 18:2/16:0-PC+blood 16:0/18:0-PS+blood 0 0 -0.414017094 serum_phospholipids serum_phospholipids 8.67E-05 0.377 no up up no no no 18:2/16:0-PC+blood 16:0/18:1-PC+blood 0.714285714 0.659313725 0 serum_phospholipids serum_phospholipids 8.67E-05 6.15E-07 no up up up up up 18:2/16:0-PC+blood 16:0/18:1-PE+blood -0.488721805 0 0 serum_phospholipids serum_phospholipids 8.67E-05 0.000107 no up up up up no 18:2/16:0-PC+blood 16:0/18:2-PC+blood 0.781954887 0.715686275 0.624615385 serum_phospholipids serum_phospholipids 8.67E-05 3.24E-06 no up up no up up 18:2/16:0-PC+blood 16:0/20:3-PC+blood 0.735338346 0 0 serum_phospholipids serum_phospholipids 8.67E-05 5.43E-06 no up up no up up 18:2/16:0-PC+blood 16:0/20:4-PC+blood 0.566917293 0.526960784 0.578119658 serum_phospholipids serum_phospholipids 8.67E-05 0.0262 no up up no up no 18:2/16:0-PC+blood 16:0/20:4-PI+blood -0.627067669 -0.632352941 0 serum_phospholipids serum_phospholipids 8.67E-05 0.558 no up up no no no 18:2/16:0-PC+blood 16:0/22:6-PC+blood 0.562406015 0.517156863 0.552820513 serum_phospholipids serum_phospholipids 8.67E-05 4.53E-05 no up up no up up 18:2/16:0-PC+blood 16:0+blood 0 0.519607843 0 yes serum_phospholipids serum_fattyacid 8.67E-05 0.00876 no up up up no no 18:2/16:0-PC+blood 16:1/16:0-PC+blood 0.730827068 0.519607843 0.644444444 serum_phospholipids serum_phospholipids 8.67E-05 0.0215 no up up no up up 18:2/16:0-PC+blood 16:1/16:1-PC+blood 0.65112782 0 0.533675214 serum_phospholipids serum_phospholipids 8.67E-05 0.0177 no up up no no up 18:2/16:0-PC+blood 16:1/18:1-PG+blood 0 0 -0.401025641 serum_phospholipids serum_phospholipids 8.67E-05 3.21E-05 no up up no up up 18:2/16:0-PC+blood 16:1/18:2-PG+blood 0.578947368 0 0 serum_phospholipids serum_phospholipids 8.67E-05 1.40E-08 no up up no up up 18:2/16:0-PC+blood 18:0-LPA+blood 0 0 -0.502905983 serum_phospholipids serum_phospholipids 8.67E-05 0.0725 no up up no dn no 18:2/16:0-PC+blood 18:0-LPC+blood 0 -0.62254902 0 serum_phospholipids serum_phospholipids 8.67E-05 0.554 no up up no no no 18:2/16:0-PC+blood 18:0/16:0-PC+blood 0.69924812 0.659313725 0 serum_phospholipids serum_phospholipids 8.67E-05 9.64E-07 no up up up up up 18:2/16:0-PC+blood 18:0/18:0-PE+blood -0.535338346 0 0 serum_phospholipids serum_phospholipids 8.67E-05 0.00896 no up up up up no 18:2/16:0-PC+blood 18:0/18:1-PE+blood -0.527819549 0 0 serum_phospholipids serum_phospholipids 8.67E-05 0.00716 no up up up up no 18:2/16:0-PC+blood 18:0/18:1-PI+blood 0 0 -0.405128205 serum_phospholipids serum_phospholipids 8.67E-05 0.599 no up up no no no 18:2/16:0-PC+blood 18:0/18:2-PC+blood 0.896240602 0.632352941 0.789401709 serum_phospholipids serum_phospholipids 8.67E-05 1.74E-06 no up up no up up 18:2/16:0-PC+blood 18:0/20:3-PC+blood 0 -0.539215686 0 serum_phospholipids serum_phospholipids 8.67E-05 0.0682 no up up no up no 18:2/16:0-PC+blood 18:0/20:4-PC+blood 0.536842105 0 0.490598291 serum_phospholipids serum_phospholipids 8.67E-05 0.454 no up up no no no 18:2/16:0-PC+blood 18:0/20:5-PC+blood 0 0 0.626666667 serum_phospholipids serum_phospholipids 8.67E-05 0.17 no up up no no no 18:2/16:0-PC+blood 18:1/16:0-PC+blood 0.756390977 0.732843137 0.619145299 serum_phospholipids serum_phospholipids 8.67E-05 2.43E-05 no up up no up up 18:2/16:0-PC+blood 18:1/16:0-PE+blood -0.518796992 0 0 serum_phospholipids serum_phospholipids 8.67E-05 0.000182 no up up up up no 18:2/16:0-PC+blood 18:1/16:0-PI+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 8.67E-05 0.793 no up up no no no 18:2/16:0-PC+blood 18:1/16:1-PE+blood -0.490225564 0 0 serum_phospholipids serum_phospholipids 8.67E-05 0.000184 no up up up up no 18:2/16:0-PC+blood 18:1/18:0-PC+blood 0.891729323 0.639705882 0.797606838 serum_phospholipids serum_phospholipids 8.67E-05 1.83E-06 no up up no up up 18:2/16:0-PC+blood 18:1/18:1-PC+blood 0.645112782 0 0 serum_phospholipids serum_phospholipids 8.67E-05 1.34E-05 no up up no up up 18:2/16:0-PC+blood 18:1/18:1-PI+blood 0 -0.632352941 0 serum_phospholipids serum_phospholipids 8.67E-05 0.111 no up up dn no no 18:2/16:0-PC+blood 18:1/18:2-PG+blood 0.6 0 0 serum_phospholipids serum_phospholipids 8.67E-05 5.58E-07 no up up no up up 18:2/16:0-PC+blood 18:2-LPC+blood 0.542857143 0 0 serum_phospholipids serum_phospholipids 8.67E-05 0.00743 no up up dn no up 18:2/16:0-PC+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.541353383 serum_phospholipids stool_cometabolism 8.67E-05 0.33 no up up no no no 18:2/16:0-PC+blood Adherens junction 0 0 -0.453846154 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Alistipes 0 -0.543225117 0 serum_phospholipids Genus 8.67E-05 0.0114 no up up no up no 18:2/16:0-PC+blood Allograft rejection 0 0 -0.516923077 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.450769231 serum_phospholipids kegg 8.67E-05 NA no up up no up up 18:2/16:0-PC+blood Autoimmune thyroid disease 0 0 -0.516923077 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Butyricicoccus -0.509933395 0 -0.438953875 butyrate-producing serum_phospholipids Genus 8.67E-05 0.852 no up up no no no 18:2/16:0-PC+blood Cardiac muscle contraction 0 0 -0.442307692 serum_phospholipids kegg 8.67E-05 NA no up up no no up 18:2/16:0-PC+blood Cell adhesion molecules 0 0 -0.455384615 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Cellular senescence 0 0 -0.436923077 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Central carbon metabolism in cancer 0 -0.694117647 0.411538462 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Diabetic cardiomyopathy 0 0 -0.414615385 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Dilated cardiomyopathy 0 0 -0.426153846 serum_phospholipids kegg 8.67E-05 NA no up up no up up 18:2/16:0-PC+blood Endocytosis 0 0 -0.408461538 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Fluid shear stress and atherosclerosis 0 0 -0.43 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Gastric acid secretion 0 0 -0.436923077 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Graft-versus-host disease 0 0 -0.500769231 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Hepatocellular carcinoma 0 0 -0.480769231 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Hippo signaling pathway 0 0 -0.43 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Human papillomavirus infection 0 0 -0.466153846 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Hypertrophic cardiomyopathy 0 0 -0.43 serum_phospholipids kegg 8.67E-05 NA no up up no up up 18:2/16:0-PC+blood Inflammatory bowel disease 0 0 -0.41 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Influenza A 0 0 -0.434615385 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood L-Phenylalanine+stool 0 0 0.469172932 serum_phospholipids stool_cometabolism 8.67E-05 0.398 no up up no no no 18:2/16:0-PC+blood L-Tyrosine+stool 0 0 0.488721805 serum_phospholipids stool_cometabolism 8.67E-05 0.44 no up up no no no 18:2/16:0-PC+blood Malaria 0 0 0.520769231 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood mRNA surveillance pathway 0 -0.523529412 0 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood mTOR signaling pathway 0 0 0.450769231 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Phagosome 0 0 -0.409230769 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Platelet activation 0 0 -0.43 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Prion disease 0 0 -0.426923077 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Protein processing in endoplasmic reticulum 0 0 0.423076923 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Rap1 signaling pathway 0 0 -0.426153846 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Renal cell carcinoma 0 -0.582352941 0.402307692 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Ruminococcus 0 -0.644607843 0 acetate-producing serum_phospholipids Genus 8.67E-05 0.335 no up up no no no 18:2/16:0-PC+blood TCA+stool -0.651995115 0 0 serum_phospholipids stool_bileacids 8.67E-05 0.458 no up up no no no 18:2/16:0-PC+blood Thyroid hormone signaling pathway 0 0 -0.655384615 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Type I diabetes mellitus 0 0 -0.504615385 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood UDCA+stool 0 0 -0.523308271 serum_phospholipids stool_bileacids 8.67E-05 0.266 no up up no no no 18:2/16:0-PC+blood Vibrio cholerae infection 0 0 -0.430769231 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Viral carcinogenesis 0 0 -0.463846154 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/16:0-PC+blood Viral myocarditis 0 0 -0.590769231 serum_phospholipids kegg 8.67E-05 NA no up up no no no 18:2/18:1-PC+blood 12-ketoDCA+blood -0.493662555 0 0 serum_phospholipids serum_bileacids 2.30E-05 0.517 dn up up no no no 18:2/18:1-PC+blood 14:0/16:0-PC+blood -0.527819549 0 0 serum_phospholipids serum_phospholipids 2.30E-05 0.0358 dn up up no up no 18:2/18:1-PC+blood 14:0/18:2-PC+blood 0 0.504901961 0 serum_phospholipids serum_phospholipids 2.30E-05 0.102 dn up up no up no 18:2/18:1-PC+blood 16:0-LPE+blood -0.536842105 0 0 serum_phospholipids serum_phospholipids 2.30E-05 0.0711 dn up up up up no 18:2/18:1-PC+blood 16:0/16:0-PI+blood -0.560902256 0 0 serum_phospholipids serum_phospholipids 2.30E-05 0.358 dn up up no no no 18:2/18:1-PC+blood 16:0/16:1-PI+blood -0.479699248 0 0 serum_phospholipids serum_phospholipids 2.30E-05 0.262 dn up up no no no 18:2/18:1-PC+blood 16:0/18:0-PC+blood 0 0 0.734017094 serum_phospholipids serum_phospholipids 2.30E-05 0.521 dn up up no no no 18:2/18:1-PC+blood 16:0/18:0-PS+blood 0 0 -0.52 serum_phospholipids serum_phospholipids 2.30E-05 0.377 dn up up no no no 18:2/18:1-PC+blood 16:0/18:1-PE+blood 0 0 -0.452307692 serum_phospholipids serum_phospholipids 2.30E-05 0.000107 dn up up up up no 18:2/18:1-PC+blood 16:0/18:3-PC+blood 0 0.553921569 0 serum_phospholipids serum_phospholipids 2.30E-05 0.00216 dn up up no up up 18:2/18:1-PC+blood 16:0/20:3-PC+blood 0.613533835 0 0 serum_phospholipids serum_phospholipids 2.30E-05 5.43E-06 dn up up no up up 18:2/18:1-PC+blood 16:0/20:4-PE+blood 0 0 -0.47008547 serum_phospholipids serum_phospholipids 2.30E-05 0.00139 dn up up up up no 18:2/18:1-PC+blood 16:0/20:4-PI+blood -0.457142857 0 0 serum_phospholipids serum_phospholipids 2.30E-05 0.558 dn up up no no no 18:2/18:1-PC+blood 16:0/20:5-PC+blood -0.458646617 0 0 serum_phospholipids serum_phospholipids 2.30E-05 0.628 dn up up no no no 18:2/18:1-PC+blood 16:1/18:1-PG+blood 0 0 -0.548034188 serum_phospholipids serum_phospholipids 2.30E-05 3.21E-05 dn up up no up up 18:2/18:1-PC+blood 18:0-LPC+blood 0 0 0.534358974 serum_phospholipids serum_phospholipids 2.30E-05 0.554 dn up up no no no 18:2/18:1-PC+blood 18:0/18:0-PS+blood 0 0 -0.526153846 serum_phospholipids serum_phospholipids 2.30E-05 0.00617 dn up up no up no 18:2/18:1-PC+blood 18:0/20:2-PC+blood 0 0 0.460512821 serum_phospholipids serum_phospholipids 2.30E-05 0.733 dn up up no no no 18:2/18:1-PC+blood 18:0/22:6-PC+blood 0 -0.595588235 0 serum_phospholipids serum_phospholipids 2.30E-05 0.0775 dn up up no no up 18:2/18:1-PC+blood 18:0/22:6-PI+blood 0 -0.541666667 0 serum_phospholipids serum_phospholipids 2.30E-05 0.425 dn up up no no no 18:2/18:1-PC+blood 18:1-LPC+blood 0.676691729 0 0.435897436 serum_phospholipids serum_phospholipids 2.30E-05 0.179 dn up up no no no 18:2/18:1-PC+blood 18:1-LPE+blood 0 0 0.435897436 serum_phospholipids serum_phospholipids 2.30E-05 0.117 dn up up no no no 18:2/18:1-PC+blood 18:1/16:1-PE+blood 0 0 -0.452991453 serum_phospholipids serum_phospholipids 2.30E-05 0.000184 dn up up up up no 18:2/18:1-PC+blood 18:1/18:1-PC+blood 0.696240602 0 0 serum_phospholipids serum_phospholipids 2.30E-05 1.34E-05 dn up up no up up 18:2/18:1-PC+blood 18:1/18:1-PG+blood 0 0 -0.414017094 serum_phospholipids serum_phospholipids 2.30E-05 0.00352 dn up up no up up 18:2/18:1-PC+blood 18:1/18:1-PI+blood 0.523308271 0 0 serum_phospholipids serum_phospholipids 2.30E-05 0.111 dn up up dn no no 18:2/18:1-PC+blood 18:1/18:2-PG+blood 0.455639098 0 0 serum_phospholipids serum_phospholipids 2.30E-05 5.58E-07 dn up up no up up 18:2/18:1-PC+blood 18:1/18:2-PI+blood 0 0 0.587008547 serum_phospholipids serum_phospholipids 2.30E-05 0.0164 dn up up dn no up 18:2/18:1-PC+blood 18:1/20:3-PC+blood 0.615037594 0 0 serum_phospholipids serum_phospholipids 2.30E-05 0.00872 dn up up no up up 18:2/18:1-PC+blood 18:1/22:6-PE+blood 0 -0.583333333 0 serum_phospholipids serum_phospholipids 2.30E-05 0.0047 dn up up no up no 18:2/18:1-PC+blood 18:2-LPC+blood 0.693233083 0.683823529 0.636923077 serum_phospholipids serum_phospholipids 2.30E-05 0.00743 dn up up dn no up 18:2/18:1-PC+blood 18:2/16:0-PC+blood 0.559398496 0 0.464615385 serum_phospholipids serum_phospholipids 2.30E-05 8.67E-05 dn up up no up up 18:2/18:1-PC+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.505263158 serum_phospholipids stool_cometabolism 2.30E-05 0.33 dn up up no no no 18:2/18:1-PC+blood AMPK signaling pathway 0 0 0.47 serum_phospholipids kegg 2.30E-05 NA dn up up no no no 18:2/18:1-PC+blood Arginine and proline metabolism 0 0 -0.447692308 serum_phospholipids kegg 2.30E-05 NA dn up up no up no 18:2/18:1-PC+blood Longevity regulating pathway 0 0 0.407692308 serum_phospholipids kegg 2.30E-05 NA dn up up no no no 18:2/18:1-PC+blood Platinum drug resistance 0 0 0.431538462 serum_phospholipids kegg 2.30E-05 NA dn up up no no no 18:2/18:1-PC+blood Proteasome 0 0 -0.445384615 serum_phospholipids kegg 2.30E-05 NA dn up up no no no 18:2/18:1-PC+blood Ruminococcus 0 0 -0.483076923 acetate-producing serum_phospholipids Genus 2.30E-05 0.335 dn up up no no no 18:2/18:1-PC+blood Slackia 0 0 0.402933181 serum_phospholipids Genus 2.30E-05 0.94 dn up up no no no 18:2/18:2-PC+blood 14:0/16:0-PC+blood -0.485714286 0 0 serum_phospholipids serum_phospholipids 1.98E-05 0.0358 dn up up no up no 18:2/18:2-PC+blood 14:0/18:2-PC+blood 0 0.529411765 0 serum_phospholipids serum_phospholipids 1.98E-05 0.102 dn up up no up no 18:2/18:2-PC+blood 14:0/20:4-PC+blood 0 0.50245098 0 serum_phospholipids serum_phospholipids 1.98E-05 0.486 dn up up no no no 18:2/18:2-PC+blood 16:0-LPE+blood -0.505263158 0 0 serum_phospholipids serum_phospholipids 1.98E-05 0.0711 dn up up up up no 18:2/18:2-PC+blood 16:0/16:0-PI+blood -0.527819549 0 0 serum_phospholipids serum_phospholipids 1.98E-05 0.358 dn up up no no no 18:2/18:2-PC+blood 16:0/18:0-PC+blood 0 0 0.729230769 serum_phospholipids serum_phospholipids 1.98E-05 0.521 dn up up no no no 18:2/18:2-PC+blood 16:0/18:0-PS+blood 0 0 -0.532991453 serum_phospholipids serum_phospholipids 1.98E-05 0.377 dn up up no no no 18:2/18:2-PC+blood 16:0/18:1-PE+blood 0 0 -0.44 serum_phospholipids serum_phospholipids 1.98E-05 0.000107 dn up up up up no 18:2/18:2-PC+blood 16:0/18:3-PC+blood 0 0.588235294 0 serum_phospholipids serum_phospholipids 1.98E-05 0.00216 dn up up no up up 18:2/18:2-PC+blood 16:0/20:3-PC+blood 0.57443609 0 0 serum_phospholipids serum_phospholipids 1.98E-05 5.43E-06 dn up up no up up 18:2/18:2-PC+blood 16:0/20:4-PE+blood 0 0 -0.444786325 serum_phospholipids serum_phospholipids 1.98E-05 0.00139 dn up up up up no 18:2/18:2-PC+blood 16:1/18:1-PG+blood 0 0 -0.596581197 serum_phospholipids serum_phospholipids 1.98E-05 3.21E-05 dn up up no up up 18:2/18:2-PC+blood 18:0-LPC+blood 0 0 0.521367521 serum_phospholipids serum_phospholipids 1.98E-05 0.554 dn up up no no no 18:2/18:2-PC+blood 18:0/18:0-PS+blood 0 0 -0.528888889 serum_phospholipids serum_phospholipids 1.98E-05 0.00617 dn up up no up no 18:2/18:2-PC+blood 18:0/18:1-PG+blood 0 0 -0.403076923 serum_phospholipids serum_phospholipids 1.98E-05 0.000842 dn up up no up no 18:2/18:2-PC+blood 18:0/20:2-PC+blood 0 0 0.454358974 serum_phospholipids serum_phospholipids 1.98E-05 0.733 dn up up no no no 18:2/18:2-PC+blood 18:0/22:6-PC+blood 0 -0.585784314 0 serum_phospholipids serum_phospholipids 1.98E-05 0.0775 dn up up no no up 18:2/18:2-PC+blood 18:0/22:6-PI+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 1.98E-05 0.425 dn up up no no no 18:2/18:2-PC+blood 18:1-LPC+blood 0.621052632 0 0.431794872 serum_phospholipids serum_phospholipids 1.98E-05 0.179 dn up up no no no 18:2/18:2-PC+blood 18:1-LPE+blood 0 0 0.439316239 serum_phospholipids serum_phospholipids 1.98E-05 0.117 dn up up no no no 18:2/18:2-PC+blood 18:1/16:1-PE+blood 0 0 -0.441367521 serum_phospholipids serum_phospholipids 1.98E-05 0.000184 dn up up up up no 18:2/18:2-PC+blood 18:1/18:1-PC+blood 0.678195489 0 0 serum_phospholipids serum_phospholipids 1.98E-05 1.34E-05 dn up up no up up 18:2/18:2-PC+blood 18:1/18:1-PG+blood 0 0 -0.454358974 serum_phospholipids serum_phospholipids 1.98E-05 0.00352 dn up up no up up 18:2/18:2-PC+blood 18:1/18:1-PI+blood 0.494736842 0 0 serum_phospholipids serum_phospholipids 1.98E-05 0.111 dn up up dn no no 18:2/18:2-PC+blood 18:1/18:2-PI+blood 0 0 0.615042735 serum_phospholipids serum_phospholipids 1.98E-05 0.0164 dn up up dn no up 18:2/18:2-PC+blood 18:1/20:3-PC+blood 0.554887218 0 0 serum_phospholipids serum_phospholipids 1.98E-05 0.00872 dn up up no up up 18:2/18:2-PC+blood 18:1/22:6-PE+blood 0 -0.602941176 0 serum_phospholipids serum_phospholipids 1.98E-05 0.0047 dn up up no up no 18:2/18:2-PC+blood 18:2-LPC+blood 0.736842105 0.661764706 0.642393162 serum_phospholipids serum_phospholipids 1.98E-05 0.00743 dn up up dn no up 18:2/18:2-PC+blood 18:2/16:0-PC+blood 0.514285714 0 0.450940171 serum_phospholipids serum_phospholipids 1.98E-05 8.67E-05 dn up up no up up 18:2/18:2-PC+blood 18:2/18:1-PC+blood 0.97593985 0.995098039 0.993846154 serum_phospholipids serum_phospholipids 1.98E-05 2.30E-05 dn up up dn up up 18:2/18:2-PC+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.521804511 serum_phospholipids stool_cometabolism 1.98E-05 0.33 dn up up no no no 18:2/18:2-PC+blood AMPK signaling pathway 0 0 0.462307692 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood Arginine and proline metabolism 0 0 -0.463846154 serum_phospholipids kegg 1.98E-05 NA dn up up no up no 18:2/18:2-PC+blood Blautia 0 -0.50245098 0 acetate-producing serum_phospholipids Genus 1.98E-05 1.36E-05 dn up up up dn dn 18:2/18:2-PC+blood Collinsella -0.566265702 0 0 serum_phospholipids Genus 1.98E-05 0.128 dn up up no no no 18:2/18:2-PC+blood Estrogen signaling pathway 0 0 0.407692308 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood FoxO signaling pathway 0 0 0.408461538 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood Intestinal immune network for IgA production 0.526315789 0 0 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood Legionellosis 0 0.570588235 0 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood Longevity regulating pathway 0 0 0.401538462 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood Longevity regulating pathway - multiple species -0.48245614 0 0 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood Malaria 0 0.502941176 0 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood Mineral absorption 0 0.55 0 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood Necroptosis 0 0.538235294 0 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood Non-alcoholic fatty liver disease 0 0.597058824 0 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood "Parathyroid hormone synthesis, secretion and action" 0 0.511764706 0 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood Peroxisome -0.456140351 0 0 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood Phenylacetic acid+stool 0.615384615 0 0 serum_phospholipids stool_cometabolism 1.98E-05 0.785 dn up up no no no 18:2/18:2-PC+blood Platinum drug resistance 0 0 0.436923077 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood Proteasome 0 0 -0.458461538 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood Ruminococcus 0 0 -0.476923077 acetate-producing serum_phospholipids Genus 1.98E-05 0.335 dn up up no no no 18:2/18:2-PC+blood Slackia 0 0 0.427774931 serum_phospholipids Genus 1.98E-05 0.94 dn up up no no no 18:2/18:2-PC+blood Th1 and Th2 cell differentiation 0.542105263 0 0 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PC+blood Th17 cell differentiation 0.603508772 0 0 serum_phospholipids kegg 1.98E-05 NA dn up up no no no 18:2/18:2-PS+blood 11-HETE+blood 0 0.780064817 0 serum_phospholipids serum_ARA 0.00674 0.464 up up no no no no 18:2/18:2-PS+blood 12-HEPE+blood -0.507974499 0 0 serum_phospholipids serum_ARA 0.00674 0.312 up up no no no no 18:2/18:2-PS+blood 12-ketoDCA+blood 0 -0.484097716 0 serum_phospholipids serum_bileacids 0.00674 0.517 up up no no no no 18:2/18:2-PS+blood 14:0/18:0-PC+blood 0 0.676470588 0 serum_phospholipids serum_phospholipids 0.00674 0.00289 up up no up up no 18:2/18:2-PS+blood 15-HETE+blood -0.671231383 0 0 serum_phospholipids serum_ARA 0.00674 0.819 up up no no no no 18:2/18:2-PS+blood 16:0/16:1-PC+blood 0 0.683823529 0 serum_phospholipids serum_phospholipids 0.00674 0.00283 up up no up up no 18:2/18:2-PS+blood 16:0/16:1-PI+blood 0 0.602941176 0 serum_phospholipids serum_phospholipids 0.00674 0.262 up up no no no no 18:2/18:2-PS+blood 16:0/18:0-PS+blood 0.801503759 0 0.831794872 serum_phospholipids serum_phospholipids 0.00674 0.377 up up no no no no 18:2/18:2-PS+blood 16:0/18:1-PE+blood 0.62556391 0.742647059 0 serum_phospholipids serum_phospholipids 0.00674 0.000107 up up no up up no 18:2/18:2-PS+blood 16:0/18:2-PI+blood 0 0.529411765 0 serum_phospholipids serum_phospholipids 0.00674 0.269 up up no no no no 18:2/18:2-PS+blood 16:0/20:4-PE+blood 0.696240602 0.737745098 0 serum_phospholipids serum_phospholipids 0.00674 0.00139 up up no up up no 18:2/18:2-PS+blood 16:0/20:5-PG+blood 0 0 0.410598291 serum_phospholipids serum_phospholipids 0.00674 0.00656 up up no no up no 18:2/18:2-PS+blood 16:0/22:6-PC+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 0.00674 4.53E-05 up up no no up up 18:2/18:2-PS+blood 16:0/22:6-PE+blood 0.6 0.485294118 0.442051282 serum_phospholipids serum_phospholipids 0.00674 0.000934 up up no up up no 18:2/18:2-PS+blood 16:1/18:1-PG+blood 0 0.544117647 0.701196581 serum_phospholipids serum_phospholipids 0.00674 3.21E-05 up up no no up up 18:2/18:2-PS+blood 16:1/18:2-PG+blood 0 0.485294118 0.558290598 serum_phospholipids serum_phospholipids 0.00674 1.40E-08 up up no no up up 18:2/18:2-PS+blood 18:0-LPE+blood 0.586466165 0 0 serum_phospholipids serum_phospholipids 0.00674 0.491 up up no no no no 18:2/18:2-PS+blood 18:0/18:0-PS+blood 0.75037594 0 0.817435897 serum_phospholipids serum_phospholipids 0.00674 0.00617 up up no no up no 18:2/18:2-PS+blood 18:0/18:1-PG+blood 0 0 0.495384615 serum_phospholipids serum_phospholipids 0.00674 0.000842 up up no no up no 18:2/18:2-PS+blood 18:0/18:1-PI+blood 0 0.68872549 0 serum_phospholipids serum_phospholipids 0.00674 0.599 up up no no no no 18:2/18:2-PS+blood 18:0/18:2-PI+blood 0 0.507352941 0 serum_phospholipids serum_phospholipids 0.00674 0.179 up up no no no no 18:2/18:2-PS+blood 18:0/20:2-PC+blood 0 0 -0.408547009 serum_phospholipids serum_phospholipids 0.00674 0.733 up up no no no no 18:2/18:2-PS+blood 18:0/20:3-PC+blood 0 0.482843137 0 serum_phospholipids serum_phospholipids 0.00674 0.0682 up up no no up no 18:2/18:2-PS+blood 18:0/20:3-PI+blood 0 0.612745098 0 serum_phospholipids serum_phospholipids 0.00674 0.377 up up no no no no 18:2/18:2-PS+blood 18:0/20:4-PC+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.00674 0.454 up up no no no no 18:2/18:2-PS+blood 18:0/20:4-PI+blood 0 0 0.460512821 serum_phospholipids serum_phospholipids 0.00674 0.167 up up no no no no 18:2/18:2-PS+blood 18:0/20:5-PC+blood 0 -0.703431373 -0.538461538 serum_phospholipids serum_phospholipids 0.00674 0.17 up up no no no no 18:2/18:2-PS+blood 18:0/22:6-PA+blood 0 0 0.472136752 serum_phospholipids serum_phospholipids 0.00674 0.22 up up no no no no 18:2/18:2-PS+blood 18:0/22:6-PE+blood 0.44962406 0 0 serum_phospholipids serum_phospholipids 0.00674 0.00022 up up no up up no 18:2/18:2-PS+blood 18:1/16:0-PE+blood 0.560902256 0.647058824 0 serum_phospholipids serum_phospholipids 0.00674 0.000182 up up no up up no 18:2/18:2-PS+blood 18:1/16:0-PI+blood 0 0.588235294 0 serum_phospholipids serum_phospholipids 0.00674 0.793 up up no no no no 18:2/18:2-PS+blood 18:1/16:1-PE+blood 0.645112782 0.737745098 0 serum_phospholipids serum_phospholipids 0.00674 0.000184 up up no up up no 18:2/18:2-PS+blood 18:1/18:0-PE+blood 0.6 0.625 0 serum_phospholipids serum_phospholipids 0.00674 1.39E-06 up up no up up no 18:2/18:2-PS+blood 18:1/18:0-PI+blood 0.479699248 0.526960784 0 serum_phospholipids serum_phospholipids 0.00674 0.0931 up up no no no up 18:2/18:2-PS+blood 18:1/18:0-PS+blood 0 0 0.632820513 serum_phospholipids serum_phospholipids 0.00674 0.193 up up no no no no 18:2/18:2-PS+blood 18:1/18:1-PE+blood 0.658646617 0.62745098 0 serum_phospholipids serum_phospholipids 0.00674 1.03E-05 up up no up up no 18:2/18:2-PS+blood 18:1/18:1-PG+blood 0 0.517156863 0.573333333 serum_phospholipids serum_phospholipids 0.00674 0.00352 up up no no up up 18:2/18:2-PS+blood 18:1/18:2-PE+blood 0 0.642156863 0 serum_phospholipids serum_phospholipids 0.00674 0.000293 up up no up up no 18:2/18:2-PS+blood 18:1/18:2-PG+blood 0 0.529411765 0.511794872 serum_phospholipids serum_phospholipids 0.00674 5.58E-07 up up no no up up 18:2/18:2-PS+blood 18:1/18:2-PI+blood 0 0 -0.455042735 serum_phospholipids serum_phospholipids 0.00674 0.0164 up up no dn no up 18:2/18:2-PS+blood 18:1/20:3-PC+blood 0 0 -0.422222222 serum_phospholipids serum_phospholipids 0.00674 0.00872 up up no no up up 18:2/18:2-PS+blood 18:1/20:4-PC+blood 0 -0.610294118 0 serum_phospholipids serum_phospholipids 0.00674 0.582 up up no no no no 18:2/18:2-PS+blood 18:1/20:4-PE+blood 0.54887218 0 0 serum_phospholipids serum_phospholipids 0.00674 0.0578 up up no up no no 18:2/18:2-PS+blood 18:2/18:2-PC+blood 0 0 -0.403760684 serum_phospholipids serum_phospholipids 0.00674 1.98E-05 up up no dn up up 18:2/18:2-PS+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 0.494736842 serum_phospholipids stool_cometabolism 0.00674 0.33 up up no no no no 18:2/18:2-PS+blood Adrenergic signaling in cardiomyocytes 0 0 0.424615385 serum_phospholipids kegg 0.00674 NA up up no no no up 18:2/18:2-PS+blood Calcium signaling pathway 0 0 0.454615385 serum_phospholipids kegg 0.00674 NA up up no no up up 18:2/18:2-PS+blood Carbon metabolism 0 0 -0.405384615 serum_phospholipids kegg 0.00674 NA up up no no no no 18:2/18:2-PS+blood Dopaminergic synapse 0 0 0.523076923 serum_phospholipids kegg 0.00674 NA up up no no up no 18:2/18:2-PS+blood Glycolysis / Gluconeogenesis 0 0 -0.43 serum_phospholipids kegg 0.00674 NA up up no no no no 18:2/18:2-PS+blood Long-term potentiation 0 0 0.502307692 serum_phospholipids kegg 0.00674 NA up up no no no up 18:2/18:2-PS+blood Neurotrophin signaling pathway 0 0 0.412307692 serum_phospholipids kegg 0.00674 NA up up no no no no 18:2/18:2-PS+blood Peroxisome 0 0 -0.45 serum_phospholipids kegg 0.00674 NA up up no no no no 18:2/20:4-PC+blood "12,13-EPOME+blood" 0 -0.623819213 0 serum_phospholipids serum_ARA 0.0145 0.901 no no up no no no 18:2/20:4-PC+blood 14:0/18:0-PC+blood 0 -0.524509804 0 serum_phospholipids serum_phospholipids 0.0145 0.00289 no no up up up no 18:2/20:4-PC+blood 14:0/20:4-PC+blood 0 0.693627451 0 serum_phospholipids serum_phospholipids 0.0145 0.486 no no up no no no 18:2/20:4-PC+blood 16:0/16:0-PI+blood 0 -0.512254902 0 serum_phospholipids serum_phospholipids 0.0145 0.358 no no up no no no 18:2/20:4-PC+blood 16:0/16:1-PC+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.0145 0.00283 no no up up up no 18:2/20:4-PC+blood 16:0/16:1-PI+blood 0 0 -0.417435897 serum_phospholipids serum_phospholipids 0.0145 0.262 no no up no no no 18:2/20:4-PC+blood 16:0/18:1-PE+blood 0 -0.769607843 0 serum_phospholipids serum_phospholipids 0.0145 0.000107 no no up up up no 18:2/20:4-PC+blood 16:0/18:2-PI+blood 0 -0.681372549 0 serum_phospholipids serum_phospholipids 0.0145 0.269 no no up no no no 18:2/20:4-PC+blood 16:0/20:4-PC+blood 0 0.531862745 0.442051282 serum_phospholipids serum_phospholipids 0.0145 0.0262 no no up no up no 18:2/20:4-PC+blood 16:0/20:4-PE+blood -0.509774436 -0.600490196 0 serum_phospholipids serum_phospholipids 0.0145 0.00139 no no up up up no 18:2/20:4-PC+blood 16:0/20:5-PC+blood 0.512781955 0 0 serum_phospholipids serum_phospholipids 0.0145 0.628 no no up no no no 18:2/20:4-PC+blood 16:0/20:5-PG+blood 0 0.669117647 0 serum_phospholipids serum_phospholipids 0.0145 0.00656 no no up no up no 18:2/20:4-PC+blood 16:0/22:0-PE+blood 0.454135338 0 0 serum_phospholipids serum_phospholipids 0.0145 0.00839 no no up dn no up 18:2/20:4-PC+blood 16:0/22:6-PC+blood 0.463157895 0 0 serum_phospholipids serum_phospholipids 0.0145 4.53E-05 no no up no up up 18:2/20:4-PC+blood 16:1/18:1-PG+blood 0 0 -0.462564103 serum_phospholipids serum_phospholipids 0.0145 3.21E-05 no no up no up up 18:2/20:4-PC+blood 16:1+blood 0 0 -0.476239316 yes serum_phospholipids serum_fattyacid 0.0145 0.0186 no no up no no dn 18:2/20:4-PC+blood 18:0/18:1-PE+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.0145 0.00716 no no up up up no 18:2/20:4-PC+blood 18:0/20:4-PC+blood 0.481203008 0.558823529 0.45982906 serum_phospholipids serum_phospholipids 0.0145 0.454 no no up no no no 18:2/20:4-PC+blood 18:0/20:5-PC+blood 0.717293233 0.546568627 0.448888889 serum_phospholipids serum_phospholipids 0.0145 0.17 no no up no no no 18:2/20:4-PC+blood 18:0/22:6-PC+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.0145 0.0775 no no up no no up 18:2/20:4-PC+blood 18:0/22:6-PI+blood 0 0 -0.456410256 serum_phospholipids serum_phospholipids 0.0145 0.425 no no up no no no 18:2/20:4-PC+blood 18:1-LPC+blood 0 0.610294118 0 serum_phospholipids serum_phospholipids 0.0145 0.179 no no up no no no 18:2/20:4-PC+blood 18:1-LPE+blood -0.538345865 0 0.403760684 serum_phospholipids serum_phospholipids 0.0145 0.117 no no up no no no 18:2/20:4-PC+blood 18:1/16:0-PE+blood 0 -0.742647059 0 serum_phospholipids serum_phospholipids 0.0145 0.000182 no no up up up no 18:2/20:4-PC+blood 18:1/16:0-PI+blood 0 -0.517156863 0 serum_phospholipids serum_phospholipids 0.0145 0.793 no no up no no no 18:2/20:4-PC+blood 18:1/16:1-PE+blood -0.47518797 -0.796568627 0 serum_phospholipids serum_phospholipids 0.0145 0.000184 no no up up up no 18:2/20:4-PC+blood 18:1/18:0-PE+blood -0.491729323 -0.580882353 0 serum_phospholipids serum_phospholipids 0.0145 1.39E-06 no no up up up no 18:2/20:4-PC+blood 18:1/18:1-PE+blood 0 -0.524509804 0 serum_phospholipids serum_phospholipids 0.0145 1.03E-05 no no up up up no 18:2/20:4-PC+blood 18:1/18:2-PE+blood 0 -0.615196078 0 serum_phospholipids serum_phospholipids 0.0145 0.000293 no no up up up no 18:2/20:4-PC+blood 18:1/18:2-PI+blood 0 0 0.418119658 serum_phospholipids serum_phospholipids 0.0145 0.0164 no no up dn no up 18:2/20:4-PC+blood 18:1/20:3-PC+blood 0 0 0.508376068 serum_phospholipids serum_phospholipids 0.0145 0.00872 no no up no up up 18:2/20:4-PC+blood 18:1/20:4-PC+blood 0.512781955 0.602941176 0.42017094 serum_phospholipids serum_phospholipids 0.0145 0.582 no no up no no no 18:2/20:4-PC+blood 18:1/20:4-PI+blood 0.520300752 0 0.487863248 serum_phospholipids serum_phospholipids 0.0145 0.192 no no up no no no 18:2/20:4-PC+blood 18:2-LPC+blood 0 0 0.403760684 serum_phospholipids serum_phospholipids 0.0145 0.00743 no no up dn no up 18:2/20:4-PC+blood 18:2/18:1-PC+blood 0 0 0.470769231 serum_phospholipids serum_phospholipids 0.0145 2.30E-05 no no up dn up up 18:2/20:4-PC+blood 18:2/18:2-PC+blood 0 0 0.524102564 serum_phospholipids serum_phospholipids 0.0145 1.98E-05 no no up dn up up 18:2/20:4-PC+blood 18:2/18:2-PS+blood -0.493233083 0 0 serum_phospholipids serum_phospholipids 0.0145 0.00674 no no up up up no 18:2/20:4-PC+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.455639098 serum_phospholipids stool_cometabolism 0.0145 0.33 no no up no no no 18:2/20:4-PC+blood Acetic acid+stool -0.565934066 0 0 yes serum_phospholipids stool_scfa 0.0145 0.0656 no no up dn no no 18:2/20:4-PC+blood Alistipes 0 0.521152765 0 serum_phospholipids Genus 0.0145 0.0114 no no up no up no 18:2/20:4-PC+blood Amoebiasis 0.480701754 0 0 serum_phospholipids kegg 0.0145 NA no no up no no no 18:2/20:4-PC+blood Arginine and proline metabolism 0 0 -0.401538462 serum_phospholipids kegg 0.0145 NA no no up no up no 18:2/20:4-PC+blood Autophagy - animal 0 0 0.409230769 serum_phospholipids kegg 0.0145 NA no no up no no no 18:2/20:4-PC+blood Bacteroides 0 0 -0.524102564 LPS-producing serum_phospholipids Genus 0.0145 0.000267 no no up dn dn up 18:2/20:4-PC+blood Bifidobacterium 0 0 -0.540336529 acetate-producing serum_phospholipids Genus 0.0145 0.105 no no up no dn no 18:2/20:4-PC+blood Butyricicoccus 0 -0.504841524 0 butyrate-producing serum_phospholipids Genus 0.0145 0.852 no no up no no no 18:2/20:4-PC+blood Cellular senescence 0.501754386 0 0 serum_phospholipids kegg 0.0145 NA no no up no no no 18:2/20:4-PC+blood Chemokine signaling pathway 0.466666667 0 0 serum_phospholipids kegg 0.0145 NA no no up no no no 18:2/20:4-PC+blood Clostridium 0 -0.492696923 0 serum_phospholipids Genus 0.0145 0.925 no no up no no no 18:2/20:4-PC+blood Collinsella 0 -0.763269747 0 serum_phospholipids Genus 0.0145 0.128 no no up no no no 18:2/20:4-PC+blood Cytosolic DNA-sensing pathway 0 0 -0.413846154 serum_phospholipids kegg 0.0145 NA no no up no no no 18:2/20:4-PC+blood Human papillomavirus infection 0.470175439 0 0 serum_phospholipids kegg 0.0145 NA no no up no no no 18:2/20:4-PC+blood iso-LCA+stool -0.580468225 0 0 serum_phospholipids stool_bileacids 0.0145 0.72 no no up no no no 18:2/20:4-PC+blood L-Tyrosine+stool 0 -0.609090909 0 serum_phospholipids stool_cometabolism 0.0145 0.44 no no up no no no 18:2/20:4-PC+blood Lachnospira 0 0 0.63287764 butyrate-producing serum_phospholipids Genus 0.0145 0.279 no no up no no no 18:2/20:4-PC+blood Natural killer cell mediated cytotoxicity 0.507017544 0 0 serum_phospholipids kegg 0.0145 NA no no up no no no 18:2/20:4-PC+blood Prevotella -0.49221169 0 0 acetate-producing serum_phospholipids Genus 0.0145 0.287 no no up no no no 18:2/20:4-PC+blood Protein processing in endoplasmic reticulum -0.521052632 0 0 serum_phospholipids kegg 0.0145 NA no no up no no no 18:2/20:4-PC+blood Ruminococcus 0 -0.719803937 0 serum_phospholipids Genus 0.0145 0.0679 no no up no no dn 18:2/20:4-PC+blood Viral carcinogenesis 0.556140351 0 0 serum_phospholipids kegg 0.0145 NA no no up no no no 18:2n6c+blood 12-ketoDCA+blood -0.453868406 0 0 serum_fattyacid serum_bileacids 0.15 0.517 no no no no no no 18:2n6c+blood 14:0/18:2-PC+blood 0 0 0.413333333 serum_fattyacid serum_phospholipids 0.15 0.102 no no no no up no 18:2n6c+blood 14:0+blood 0.502255639 0 0.461880342 yes serum_fattyacid serum_fattyacid 0.15 0.00572 no no no up no dn 18:2n6c+blood 16:0/16:0-PC+blood 0 0 0.409230769 serum_fattyacid serum_phospholipids 0.15 0.00079 no no no no up up 18:2n6c+blood 16:0/18:0-PC+blood 0 0 0.501538462 serum_fattyacid serum_phospholipids 0.15 0.521 no no no no no no 18:2n6c+blood 16:0/18:0-PS+blood 0 0 -0.437948718 serum_fattyacid serum_phospholipids 0.15 0.377 no no no no no no 18:2n6c+blood 16:0/20:5-PG+blood 0 0 -0.601367521 serum_fattyacid serum_phospholipids 0.15 0.00656 no no no no up no 18:2n6c+blood 16:0+blood 0.592481203 0.757352941 0.55965812 yes serum_fattyacid serum_fattyacid 0.15 0.00876 no no no up no no 18:2n6c+blood 16:1/16:1-PC+blood 0 0 0.405128205 serum_fattyacid serum_phospholipids 0.15 0.0177 no no no no no up 18:2n6c+blood 16:1/18:1-PG+blood 0 0 -0.411965812 serum_fattyacid serum_phospholipids 0.15 3.21E-05 no no no no up up 18:2n6c+blood 16:1/18:2-PG+blood 0 0.531862745 -0.406495726 serum_fattyacid serum_phospholipids 0.15 1.40E-08 no no no no up up 18:2n6c+blood 18:0/18:0-PS+blood 0 0 -0.50974359 serum_fattyacid serum_phospholipids 0.15 0.00617 no no no no up no 18:2n6c+blood 18:0/18:2-PC+blood 0 0.62745098 0 serum_fattyacid serum_phospholipids 0.15 1.74E-06 no no no no up up 18:2n6c+blood 18:0+blood 0.592481203 0.56372549 0 serum_fattyacid serum_fattyacid 0.15 0.344 no no no no no no 18:2n6c+blood 18:1/18:0-PC+blood 0 0.647058824 0 serum_fattyacid serum_phospholipids 0.15 1.83E-06 no no no no up up 18:2n6c+blood 18:1/18:0-PI+blood 0.445112782 0 0 serum_fattyacid serum_phospholipids 0.15 0.0931 no no no no no up 18:2n6c+blood 18:1/18:1-PG+blood 0 0 -0.627350427 serum_fattyacid serum_phospholipids 0.15 0.00352 no no no no up up 18:2n6c+blood 18:1/18:2-PG+blood 0 0 -0.42017094 serum_fattyacid serum_phospholipids 0.15 5.58E-07 no no no no up up 18:2n6c+blood 18:1+blood 0.529323308 0 0 yes serum_fattyacid serum_fattyacid 0.15 0.00202 no no no up no dn 18:2n6c+blood 18:2-LPC+blood 0.509774436 0 0 serum_fattyacid serum_phospholipids 0.15 0.00743 no no no dn no up 18:2n6c+blood 18:2/16:0-PC+blood 0 0.683823529 0 serum_fattyacid serum_phospholipids 0.15 8.67E-05 no no no no up up 18:2n6c+blood 18:2/18:1-PC+blood 0 0.615196078 0.59042735 serum_fattyacid serum_phospholipids 0.15 2.30E-05 no no no dn up up 18:2n6c+blood 18:2/18:2-PC+blood 0 0.598039216 0.570598291 serum_fattyacid serum_phospholipids 0.15 1.98E-05 no no no dn up up 18:2n6c+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.452631579 serum_fattyacid stool_cometabolism 0.15 0.33 no no no no no no 18:2n6c+blood AMPK signaling pathway 0 0 0.443076923 serum_fattyacid kegg 0.15 NA no no no no no no 18:2n6c+blood Biosynthesis of cofactors 0 0 0.416923077 serum_fattyacid kegg 0.15 NA no no no no no no 18:2n6c+blood Butyricicoccus -0.52757815 0 0 butyrate-producing serum_fattyacid Genus 0.15 0.852 no no no no no no 18:2n6c+blood Glutathione metabolism 0 0 0.400769231 serum_fattyacid kegg 0.15 NA no no no no no no 18:2n6c+blood "Glycine, serine and threonine metabolism" 0 -0.573529412 0.402307692 serum_fattyacid kegg 0.15 NA no no no no up no 18:2n6c+blood Leukocyte transendothelial migration 0.480701754 0 0 serum_fattyacid kegg 0.15 NA no no no no no no 18:2n6c+blood Longevity regulating pathway 0 0 0.417692308 serum_fattyacid kegg 0.15 NA no no no no no no 18:2n6c+blood Malaria 0 0 0.456923077 serum_fattyacid kegg 0.15 NA no no no no no no 18:2n6c+blood Methanobrevibacter 0 0 0.464827733 serum_fattyacid Genus 0.15 0.629 no no no no no no 18:2n6c+blood nutriCA+stool 0 0 -0.530827068 serum_fattyacid stool_bileacids 0.15 0.481 no no no no no no 18:2n6c+blood Pancreatic cancer 0.466666667 0 0 serum_fattyacid kegg 0.15 NA no no no no no no 18:2n6c+blood Phenylacetic acid+stool 0 0 0.481203008 serum_fattyacid stool_cometabolism 0.15 0.785 no no no no no no 18:2n6c+blood Porphyrin and chlorophyll metabolism 0 0 0.439230769 serum_fattyacid kegg 0.15 NA no no no no no no 18:2n6c+blood Roseburia 0 0 -0.411965812 butyrate-producing serum_fattyacid Genus 0.15 0.495 no no no no no no 18:2n6c+blood Ruminococcus 0 -0.531862745 0 acetate-producing serum_fattyacid Genus 0.15 0.335 no no no no no no 18:2n6c+blood Salivary secretion 0.480701754 0 0 serum_fattyacid kegg 0.15 NA no no no no no no 18:2n6c+blood Sphingolipid signaling pathway 0 0 -0.499230769 serum_fattyacid kegg 0.15 NA no no no no no no 18:2n6c+blood Tuberculosis 0.501754386 0 0 serum_fattyacid kegg 0.15 NA no no no no no dn 18:2n6c+blood UDCA+stool 0 0 -0.568421053 serum_fattyacid stool_bileacids 0.15 0.266 no no no no no no 18:3-LPC+blood 14:0-LPC+blood 0.472180451 0 0 serum_phospholipids serum_phospholipids 0.147 0.00689 no no no up up no 18:3-LPC+blood 16:0-LPC+blood 0 0.529411765 0 serum_phospholipids serum_phospholipids 0.147 0.00456 no no no up up no 18:3-LPC+blood 16:0/16:1-PI+blood 0 -0.482843137 0 serum_phospholipids serum_phospholipids 0.147 0.262 no no no no no no 18:3-LPC+blood 16:0/18:0-PC+blood -0.463157895 0 0 serum_phospholipids serum_phospholipids 0.147 0.521 no no no no no no 18:3-LPC+blood 16:0/18:3-PC+blood 0.457142857 0.522058824 0.450940171 serum_phospholipids serum_phospholipids 0.147 0.00216 no no no no up up 18:3-LPC+blood 16:0/20:3-PC+blood 0 -0.68627451 0 serum_phospholipids serum_phospholipids 0.147 5.43E-06 no no no no up up 18:3-LPC+blood 16:0/20:4-PE+blood 0 0 -0.414017094 serum_phospholipids serum_phospholipids 0.147 0.00139 no no no up up no 18:3-LPC+blood 16:0/20:5-PG+blood -0.512781955 0 0 serum_phospholipids serum_phospholipids 0.147 0.00656 no no no no up no 18:3-LPC+blood 16:1/16:1-PC+blood -0.463157895 0 0 serum_phospholipids serum_phospholipids 0.147 0.0177 no no no no no up 18:3-LPC+blood 16:1/18:1-PG+blood -0.496240602 -0.713235294 0 serum_phospholipids serum_phospholipids 0.147 3.21E-05 no no no no up up 18:3-LPC+blood 18:0/18:0-PC+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.147 0.426 no no no no no no 18:3-LPC+blood 18:0/18:1-PC+blood 0 -0.529411765 0 serum_phospholipids serum_phospholipids 0.147 0.393 no no no no no no 18:3-LPC+blood 18:0/18:1-PI+blood -0.601503759 0 0 serum_phospholipids serum_phospholipids 0.147 0.599 no no no no no no 18:3-LPC+blood 18:0/20:2-PC+blood 0 -0.504901961 0 serum_phospholipids serum_phospholipids 0.147 0.733 no no no no no no 18:3-LPC+blood 18:0/20:3-PC+blood 0 -0.691176471 0 serum_phospholipids serum_phospholipids 0.147 0.0682 no no no no up no 18:3-LPC+blood 18:0/20:3-PI+blood 0 -0.776960784 0 serum_phospholipids serum_phospholipids 0.147 0.377 no no no no no no 18:3-LPC+blood 18:0/20:4-PI+blood -0.726315789 0 -0.439316239 serum_phospholipids serum_phospholipids 0.147 0.167 no no no no no no 18:3-LPC+blood 18:1/18:0-PI+blood 0 0 0.471452991 serum_phospholipids serum_phospholipids 0.147 0.0931 no no no no no up 18:3-LPC+blood 18:1/18:1-PC+blood 0 -0.68627451 0 serum_phospholipids serum_phospholipids 0.147 1.34E-05 no no no no up up 18:3-LPC+blood 18:1/18:1-PG+blood 0 -0.661764706 0 serum_phospholipids serum_phospholipids 0.147 0.00352 no no no no up up 18:3-LPC+blood 18:1/18:1-PI+blood -0.467669173 0 0 serum_phospholipids serum_phospholipids 0.147 0.111 no no no dn no no 18:3-LPC+blood 18:1/20:3-PC+blood 0 -0.647058824 0 serum_phospholipids serum_phospholipids 0.147 0.00872 no no no no up up 18:3-LPC+blood 18:1+blood 0 0 -0.476923077 yes serum_phospholipids serum_fattyacid 0.147 0.00202 no no no up no dn 18:3-LPC+blood 18:2-LPC+blood 0 0.642156863 0.477606838 serum_phospholipids serum_phospholipids 0.147 0.00743 no no no dn no up 18:3-LPC+blood 18:2-LPE+blood 0 0 0.424957265 serum_phospholipids serum_phospholipids 0.147 0.112 no no no no no no 18:3-LPC+blood 18:2/18:1-PC+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 0.147 2.30E-05 no no no dn up up 18:3-LPC+blood 18:2/18:2-PC+blood 0 0.514705882 0 serum_phospholipids serum_phospholipids 0.147 1.98E-05 no no no dn up up 18:3/16:0-PE+blood "12,13-EPOME+blood" 0 0.513586099 0 serum_phospholipids serum_ARA 0.00149 0.901 up up no no no no 18:3/16:0-PE+blood 14:0-LPC+blood 0 0 0.468717949 serum_phospholipids serum_phospholipids 0.00149 0.00689 up up no up up no 18:3/16:0-PE+blood 14:0/16:0-PC+blood 0 0 0.593162393 serum_phospholipids serum_phospholipids 0.00149 0.0358 up up no no up no 18:3/16:0-PE+blood 14:0/18:0-PC+blood 0 0.526960784 0.578803419 serum_phospholipids serum_phospholipids 0.00149 0.00289 up up no up up no 18:3/16:0-PE+blood 16:0-LPE+blood 0.553383459 0 0.589059829 serum_phospholipids serum_phospholipids 0.00149 0.0711 up up no up up no 18:3/16:0-PE+blood 16:0/14:0-PC+blood -0.454135338 0 0 serum_phospholipids serum_phospholipids 0.00149 0.0206 up up no no up up 18:3/16:0-PE+blood 16:0/16:0-PI+blood 0.533834586 0.485294118 0.632136752 serum_phospholipids serum_phospholipids 0.00149 0.358 up up no no no no 18:3/16:0-PE+blood 16:0/16:1-PC+blood 0 0.514705882 0.601367521 serum_phospholipids serum_phospholipids 0.00149 0.00283 up up no up up no 18:3/16:0-PE+blood 16:0/16:1-PI+blood 0.517293233 0 0.709401709 serum_phospholipids serum_phospholipids 0.00149 0.262 up up no no no no 18:3/16:0-PE+blood 16:0/18:0-PS+blood 0.69924812 0 0.409230769 serum_phospholipids serum_phospholipids 0.00149 0.377 up up no no no no 18:3/16:0-PE+blood 16:0/18:1-PC+blood -0.544360902 -0.593137255 0 serum_phospholipids serum_phospholipids 0.00149 6.15E-07 up up no up up up 18:3/16:0-PE+blood 16:0/18:1-PE+blood 0.796992481 0.612745098 0.725811966 serum_phospholipids serum_phospholipids 0.00149 0.000107 up up no up up no 18:3/16:0-PE+blood 16:0/18:2-PC+blood -0.694736842 0 0 serum_phospholipids serum_phospholipids 0.00149 3.24E-06 up up no no up up 18:3/16:0-PE+blood 16:0/18:2-PI+blood 0 0.703431373 0.626666667 serum_phospholipids serum_phospholipids 0.00149 0.269 up up no no no no 18:3/16:0-PE+blood 16:0/18:3-PC+blood 0 0 0.513162393 serum_phospholipids serum_phospholipids 0.00149 0.00216 up up no no up up 18:3/16:0-PE+blood 16:0/20:3-PC+blood -0.62406015 0 0 serum_phospholipids serum_phospholipids 0.00149 5.43E-06 up up no no up up 18:3/16:0-PE+blood 16:0/20:4-PC+blood -0.639097744 -0.727941176 0 serum_phospholipids serum_phospholipids 0.00149 0.0262 up up no no up no 18:3/16:0-PE+blood 16:0/20:4-PE+blood 0.596992481 0.651960784 0.543931624 serum_phospholipids serum_phospholipids 0.00149 0.00139 up up no up up no 18:3/16:0-PE+blood 16:0/20:4-PI+blood 0 0.536764706 0.657435897 serum_phospholipids serum_phospholipids 0.00149 0.558 up up no no no no 18:3/16:0-PE+blood 16:0/22:6-PC+blood -0.478195489 -0.595588235 0 serum_phospholipids serum_phospholipids 0.00149 4.53E-05 up up no no up up 18:3/16:0-PE+blood 16:0/22:6-PE+blood 0.67518797 0.590686275 0.61982906 serum_phospholipids serum_phospholipids 0.00149 0.000934 up up no up up no 18:3/16:0-PE+blood 16:1/16:0-PC+blood -0.530827068 -0.639705882 0 serum_phospholipids serum_phospholipids 0.00149 0.0215 up up no no up up 18:3/16:0-PE+blood 16:1/18:2-PG+blood -0.455639098 0 0 serum_phospholipids serum_phospholipids 0.00149 1.40E-08 up up no no up up 18:3/16:0-PE+blood 16:1+blood 0 0 0.472820513 yes serum_phospholipids serum_fattyacid 0.00149 0.0186 up up no no no dn 18:3/16:0-PE+blood 18:0/16:0-PC+blood -0.535338346 -0.647058824 0 serum_phospholipids serum_phospholipids 0.00149 9.64E-07 up up no up up up 18:3/16:0-PE+blood 18:0/18:0-PE+blood 0.67518797 0.651960784 0 serum_phospholipids serum_phospholipids 0.00149 0.00896 up up no up up no 18:3/16:0-PE+blood 18:0/18:0-PS+blood 0.532330827 0 0.424957265 serum_phospholipids serum_phospholipids 0.00149 0.00617 up up no no up no 18:3/16:0-PE+blood 18:0/18:1-PE+blood 0.69924812 0.710784314 0.460512821 serum_phospholipids serum_phospholipids 0.00149 0.00716 up up no up up no 18:3/16:0-PE+blood 18:0/18:1-PG+blood 0 0 0.460512821 serum_phospholipids serum_phospholipids 0.00149 0.000842 up up no no up no 18:3/16:0-PE+blood 18:0/18:2-PC+blood -0.586466165 0 0 serum_phospholipids serum_phospholipids 0.00149 1.74E-06 up up no no up up 18:3/16:0-PE+blood 18:0/20:2-PC+blood 0 0 -0.458461538 serum_phospholipids serum_phospholipids 0.00149 0.733 up up no no no no 18:3/16:0-PE+blood 18:0/20:4-PC+blood -0.598496241 -0.649509804 0 serum_phospholipids serum_phospholipids 0.00149 0.454 up up no no no no 18:3/16:0-PE+blood 18:0/20:5-PC+blood 0 -0.625 0 serum_phospholipids serum_phospholipids 0.00149 0.17 up up no no no no 18:3/16:0-PE+blood 18:0/22:6-PE+blood 0.613533835 0 0.426324786 serum_phospholipids serum_phospholipids 0.00149 0.00022 up up no up up no 18:3/16:0-PE+blood 18:1-LPC+blood 0 -0.522058824 -0.44957265 serum_phospholipids serum_phospholipids 0.00149 0.179 up up no no no no 18:3/16:0-PE+blood 18:1/16:0-PC+blood -0.714285714 0 0 serum_phospholipids serum_phospholipids 0.00149 2.43E-05 up up no no up up 18:3/16:0-PE+blood 18:1/16:0-PE+blood 0.836090226 0.678921569 0.745641026 serum_phospholipids serum_phospholipids 0.00149 0.000182 up up no up up no 18:3/16:0-PE+blood 18:1/16:0-PI+blood 0 0.522058824 0 serum_phospholipids serum_phospholipids 0.00149 0.793 up up no no no no 18:3/16:0-PE+blood 18:1/16:1-PE+blood 0.827067669 0.644607843 0.731282051 serum_phospholipids serum_phospholipids 0.00149 0.000184 up up no up up no 18:3/16:0-PE+blood 18:1/18:0-PC+blood -0.57443609 0 0 serum_phospholipids serum_phospholipids 0.00149 1.83E-06 up up no no up up 18:3/16:0-PE+blood 18:1/18:0-PE+blood 0.696240602 0.62745098 0.663589744 serum_phospholipids serum_phospholipids 0.00149 1.39E-06 up up no up up no 18:3/16:0-PE+blood 18:1/18:1-PC+blood -0.572932331 0 0 serum_phospholipids serum_phospholipids 0.00149 1.34E-05 up up no no up up 18:3/16:0-PE+blood 18:1/18:1-PE+blood 0.769924812 0.585784314 0.623247863 serum_phospholipids serum_phospholipids 0.00149 1.03E-05 up up no up up no 18:3/16:0-PE+blood 18:1/18:2-PE+blood 0.706766917 0.723039216 0.547350427 serum_phospholipids serum_phospholipids 0.00149 0.000293 up up no up up no 18:3/16:0-PE+blood 18:1/20:4-PC+blood -0.446616541 -0.62745098 0 serum_phospholipids serum_phospholipids 0.00149 0.582 up up no no no no 18:3/16:0-PE+blood 18:1/20:4-PE+blood 0.571428571 0.610294118 0.438632479 serum_phospholipids serum_phospholipids 0.00149 0.0578 up up no up no no 18:3/16:0-PE+blood 18:2-LPC+blood 0 0 -0.405811966 serum_phospholipids serum_phospholipids 0.00149 0.00743 up up no dn no up 18:3/16:0-PE+blood 18:2/16:0-PC+blood -0.535338346 0 0 serum_phospholipids serum_phospholipids 0.00149 8.67E-05 up up no no up up 18:3/16:0-PE+blood 18:2/18:2-PS+blood 0.618045113 0.593137255 0.408547009 serum_phospholipids serum_phospholipids 0.00149 0.00674 up up no up up no 18:3/16:0-PE+blood 18:2/20:4-PC+blood 0 -0.649509804 0 serum_phospholipids serum_phospholipids 0.00149 0.0145 up up no no no up 18:3/18:2-PC+blood 14:0/20:4-PC+blood 0.497744361 0.620098039 0.494017094 serum_phospholipids serum_phospholipids 0.0394 0.486 no no up no no no 18:3/18:2-PC+blood 16:0/18:0-PC+blood 0 0.536764706 0.677948718 serum_phospholipids serum_phospholipids 0.0394 0.521 no no up no no no 18:3/18:2-PC+blood 16:0/18:1-PE+blood 0 -0.541666667 -0.438632479 serum_phospholipids serum_phospholipids 0.0394 0.000107 no no up up up no 18:3/18:2-PC+blood 16:0/18:3-PC+blood 0.769924812 0.742647059 0 serum_phospholipids serum_phospholipids 0.0394 0.00216 no no up no up up 18:3/18:2-PC+blood 16:0/20:4-PE+blood 0 -0.526960784 -0.429059829 serum_phospholipids serum_phospholipids 0.0394 0.00139 no no up up up no 18:3/18:2-PC+blood 16:1/18:1-PG+blood 0 0 -0.478974359 serum_phospholipids serum_phospholipids 0.0394 3.21E-05 no no up no up up 18:3/18:2-PC+blood 16:1+blood 0 -0.647058824 0 yes serum_phospholipids serum_fattyacid 0.0394 0.0186 no no up no no dn 18:3/18:2-PC+blood 18:0-LPC+blood 0 0 0.446837607 serum_phospholipids serum_phospholipids 0.0394 0.554 no no up no no no 18:3/18:2-PC+blood 18:0/20:2-PC+blood 0 0 0.452307692 serum_phospholipids serum_phospholipids 0.0394 0.733 no no up no no no 18:3/18:2-PC+blood 18:0/20:3-PI+blood 0 -0.600490196 0 serum_phospholipids serum_phospholipids 0.0394 0.377 no no up no no no 18:3/18:2-PC+blood 18:1-LPC+blood 0 0 0.401709402 serum_phospholipids serum_phospholipids 0.0394 0.179 no no up no no no 18:3/18:2-PC+blood 18:1/16:1-PE+blood 0 -0.522058824 -0.450940171 serum_phospholipids serum_phospholipids 0.0394 0.000184 no no up up up no 18:3/18:2-PC+blood 18:1/22:6-PE+blood 0 -0.522058824 0 serum_phospholipids serum_phospholipids 0.0394 0.0047 no no up no up no 18:3/18:2-PC+blood 18:2-LPC+blood 0 0 0.558290598 serum_phospholipids serum_phospholipids 0.0394 0.00743 no no up dn no up 18:3/18:2-PC+blood 18:2/18:1-PC+blood 0 0.656862745 0.807863248 serum_phospholipids serum_phospholipids 0.0394 2.30E-05 no no up dn up up 18:3/18:2-PC+blood 18:2/18:2-PC+blood 0 0.683823529 0.796923077 serum_phospholipids serum_phospholipids 0.0394 1.98E-05 no no up dn up up 18:3/18:2-PC+blood 18:2/18:2-PS+blood 0 0 -0.405128205 serum_phospholipids serum_phospholipids 0.0394 0.00674 no no up up up no 18:3/18:2-PC+blood 18:2n6c+blood 0 0 0.43042735 serum_phospholipids serum_fattyacid 0.0394 0.15 no no up no no no 18:3/18:2-PC+blood 18:3-LPC+blood 0 0.566176471 0.47965812 serum_phospholipids serum_phospholipids 0.0394 0.147 no no up no no no 18:3/18:2-PC+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.50075188 serum_phospholipids stool_cometabolism 0.0394 0.33 no no up no no no 18:3/18:2-PC+blood Arginine and proline metabolism 0 0 -0.441538462 serum_phospholipids kegg 0.0394 NA no no up no up no 18:3/18:2-PC+blood B cell receptor signaling pathway 0 0 -0.467692308 serum_phospholipids kegg 0.0394 NA no no up no no no 18:3/18:2-PC+blood C-type lectin receptor signaling pathway 0 0 -0.406923077 serum_phospholipids kegg 0.0394 NA no no up no no no 18:3/18:2-PC+blood Epithelial cell signaling in Helicobacter pylori infection 0 0 -0.401538462 serum_phospholipids kegg 0.0394 NA no no up no no no 18:3/18:2-PC+blood FoxO signaling pathway 0 0 0.447692308 serum_phospholipids kegg 0.0394 NA no no up no no no 18:3/18:2-PC+blood Neurotrophin signaling pathway 0 0 -0.412307692 serum_phospholipids kegg 0.0394 NA no no up no no no 18:3/18:2-PC+blood Platinum drug resistance 0 0 0.492307692 serum_phospholipids kegg 0.0394 NA no no up no no no 18:3/18:2-PC+blood Primary immunodeficiency 0 0 0.516923077 serum_phospholipids kegg 0.0394 NA no no up no no no 18:3/18:2-PC+blood Proteasome 0 0 -0.437692308 serum_phospholipids kegg 0.0394 NA no no up no no no 18:3/18:2-PC+blood Toll-like receptor signaling pathway 0 0 -0.403076923 yes serum_phospholipids kegg 0.0394 NA no no up no no no 18:3n3+blood 12-HEPE+blood -0.462014901 0 0 serum_fattyacid serum_ARA 0.291 0.312 no no no no no no 18:3n3+blood 12-ketoDCA+blood -0.538834292 0 0 serum_fattyacid serum_bileacids 0.291 0.517 no no no no no no 18:3n3+blood 13-HODE+blood 0 0 0.571282051 serum_fattyacid serum_ARA 0.291 0.32 no no no no no no 18:3n3+blood 14:0/18:0-PC+blood 0 -0.661764706 0 serum_fattyacid serum_phospholipids 0.291 0.00289 no no no up up no 18:3n3+blood 16:0/16:0-PI+blood 0 -0.522058824 0 serum_fattyacid serum_phospholipids 0.291 0.358 no no no no no no 18:3n3+blood 16:0/16:1-PC+blood 0 -0.642156863 0 serum_fattyacid serum_phospholipids 0.291 0.00283 no no no up up no 18:3n3+blood 16:0/16:1-PI+blood 0 -0.696078431 0 serum_fattyacid serum_phospholipids 0.291 0.262 no no no no no no 18:3n3+blood 16:0/18:3-PC+blood 0.505263158 0 0 serum_fattyacid serum_phospholipids 0.291 0.00216 no no no no up up 18:3n3+blood 16:0/20:5-PG+blood 0 0 -0.427692308 serum_fattyacid serum_phospholipids 0.291 0.00656 no no no no up no 18:3n3+blood 16:0/22:6-PC+blood 0.490225564 0 0 serum_fattyacid serum_phospholipids 0.291 4.53E-05 no no no no up up 18:3n3+blood 16:0+blood 0.481203008 0 0 yes serum_fattyacid serum_fattyacid 0.291 0.00876 no no no up no no 18:3n3+blood 16:1/16:1-PC+blood 0 0.512254902 0 serum_fattyacid serum_phospholipids 0.291 0.0177 no no no no no up 18:3n3+blood 16:1/18:1-PG+blood 0 0 -0.497435897 serum_fattyacid serum_phospholipids 0.291 3.21E-05 no no no no up up 18:3n3+blood 16:1+blood 0.685714286 0 0 yes serum_fattyacid serum_fattyacid 0.291 0.0186 no no no no no dn 18:3n3+blood 18:0-LPC+blood 0 -0.482843137 0 serum_fattyacid serum_phospholipids 0.291 0.554 no no no no no no 18:3n3+blood 18:0/18:0-PC+blood 0 -0.522058824 0 serum_fattyacid serum_phospholipids 0.291 0.426 no no no no no no 18:3n3+blood 18:0/18:0-PS+blood 0.461654135 0 0 serum_fattyacid serum_phospholipids 0.291 0.00617 no no no no up no 18:3n3+blood 18:0/18:1-PC+blood 0 -0.56127451 0 serum_fattyacid serum_phospholipids 0.291 0.393 no no no no no no 18:3n3+blood 18:0/20:2-PC+blood 0 -0.715686275 0 serum_fattyacid serum_phospholipids 0.291 0.733 no no no no no no 18:3n3+blood 18:0/20:3-PC+blood 0 -0.774509804 0 serum_fattyacid serum_phospholipids 0.291 0.0682 no no no no up no 18:3n3+blood 18:0/20:3-PI+blood 0 -0.585784314 0 serum_fattyacid serum_phospholipids 0.291 0.377 no no no no no no 18:3n3+blood 18:0/22:6-PI+blood 0.527819549 0 0 serum_fattyacid serum_phospholipids 0.291 0.425 no no no no no no 18:3n3+blood 18:1/18:0-PS+blood 0.536842105 0 0 serum_fattyacid serum_phospholipids 0.291 0.193 no no no no no no 18:3n3+blood 18:1/18:1-PC+blood 0 -0.580882353 0 serum_fattyacid serum_phospholipids 0.291 1.34E-05 no no no no up up 18:3n3+blood 18:1/18:1-PG+blood 0 -0.578431373 -0.569230769 serum_fattyacid serum_phospholipids 0.291 0.00352 no no no no up up 18:3n3+blood 18:1/20:3-PC+blood 0 -0.647058824 0 serum_fattyacid serum_phospholipids 0.291 0.00872 no no no no up up 18:3n3+blood 18:1/20:4-PE+blood 0.497744361 0 0 serum_fattyacid serum_phospholipids 0.291 0.0578 no no no up no no 18:3n3+blood 18:1+blood 0.508270677 0 0 yes serum_fattyacid serum_fattyacid 0.291 0.00202 no no no up no dn 18:3n3+blood 18:2/16:0-PC+blood 0 0.524509804 0.472136752 serum_fattyacid serum_phospholipids 0.291 8.67E-05 no no no no up up 18:3n3+blood 18:2/18:2-PC+blood 0 0 0.408547009 serum_fattyacid serum_phospholipids 0.291 1.98E-05 no no no dn up up 18:3n3+blood 18:2n6c+blood 0.503759398 0 0.58017094 serum_fattyacid serum_fattyacid 0.291 0.15 no no no no no no 18:3n3+blood 18:3-LPC+blood 0 0.634803922 0 serum_fattyacid serum_phospholipids 0.291 0.147 no no no no no no 18:3n3+blood 18:3/18:2-PC+blood 0 0 0.42974359 serum_fattyacid serum_phospholipids 0.291 0.0394 no no no no no up 18:3n3+blood Adipocytokine signaling pathway -0.610526316 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood AGE-RAGE signaling pathway in diabetic complications 0.514035088 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood AMPK signaling pathway -0.649122807 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Axon guidance 0 -0.588235294 0 serum_fattyacid kegg 0.291 NA no no no no up up 18:3n3+blood Calcium signaling pathway 0 -0.582352941 0 serum_fattyacid kegg 0.291 NA no no no no up up 18:3n3+blood CDCA+stool 0.576923077 0 0 serum_fattyacid stool_bileacids 0.291 0.663 no no no no no no 18:3n3+blood cGMP-PKG signaling pathway 0.524561404 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Coronavirus disease - COVID-19 -0.554385965 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Fc gamma R-mediated phagocytosis 0.707017544 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood FoxO signaling pathway 0 0 0.448461538 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood HCA+stool 0.708791209 0 0 serum_fattyacid stool_bileacids 0.291 0.155 no no no no no no 18:3n3+blood Kaposi sarcoma-associated herpesvirus infection -0.563157895 0 0 serum_fattyacid kegg 0.291 NA no no no no no dn 18:3n3+blood Lipid and atherosclerosis 0.69122807 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Longevity regulating pathway -0.49122807 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Methanobrevibacter 0 0 0.612331615 serum_fattyacid Genus 0.291 0.629 no no no no no no 18:3n3+blood Mineral absorption -0.603508772 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Mitophagy - animal -0.685964912 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood mTOR signaling pathway -0.545614035 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Necroptosis -0.464912281 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Neutrophil extracellular trap formation 0.487719298 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood NOD-like receptor signaling pathway 0.507017544 0 0.403846154 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood nutriCA+stool 0.653846154 0 -0.517293233 serum_fattyacid stool_bileacids 0.291 0.481 no no no no no no 18:3n3+blood Olfactory transduction 0.645614035 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood "Parathyroid hormone synthesis, secretion and action" -0.498245614 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Parkinson disease -0.628070175 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Pathways of neurodegeneration - multiple diseases -0.638596491 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Peroxisome 0.503508772 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Pertussis 0.694736842 0 0 serum_fattyacid kegg 0.291 NA no no no no no dn 18:3n3+blood Purine metabolism -0.501754386 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Ribosome -0.554385965 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Ruminococcus 0 -0.504901961 0 acetate-producing serum_fattyacid Genus 0.291 0.335 no no no no no no 18:3n3+blood Salmonella infection 0.605263158 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Shigellosis -0.596491228 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood Tuberculosis 0.570175439 0 0 serum_fattyacid kegg 0.291 NA no no no no no dn 18:3n3+blood Ubiquitin mediated proteolysis -0.663157895 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n3+blood UDCA+stool 0.56043956 0 -0.464661654 serum_fattyacid stool_bileacids 0.291 0.266 no no no no no no 18:3n3+blood Yersinia infection 0.521052632 0 0 serum_fattyacid kegg 0.291 NA no no no no no no 18:3n6+blood 13-HODE+blood 0 -0.737745098 0 serum_fattyacid serum_ARA 0.0463 0.32 up no dn no no no 18:3n6+blood 14:0-LPC+blood 0 0 0.406495726 serum_fattyacid serum_phospholipids 0.0463 0.00689 up no dn up up no 18:3n6+blood 14:0/18:0-PC+blood 0.521804511 0 0 serum_fattyacid serum_phospholipids 0.0463 0.00289 up no dn up up no 18:3n6+blood 14:0/20:4-PC+blood 0.533834586 0 0.406495726 serum_fattyacid serum_phospholipids 0.0463 0.486 up no dn no no no 18:3n6+blood 14:0+blood 0.446616541 0 0 yes serum_fattyacid serum_fattyacid 0.0463 0.00572 up no dn up no dn 18:3n6+blood 16:0/16:0-PI+blood 0 0 0.405811966 serum_fattyacid serum_phospholipids 0.0463 0.358 up no dn no no no 18:3n6+blood 16:0/16:1-PC+blood 0.445112782 0 0 serum_fattyacid serum_phospholipids 0.0463 0.00283 up no dn up up no 18:3n6+blood 16:0/16:1-PI+blood 0.628571429 0 0.59042735 serum_fattyacid serum_phospholipids 0.0463 0.262 up no dn no no no 18:3n6+blood 16:0/18:1-PC+blood -0.472180451 0 0 serum_fattyacid serum_phospholipids 0.0463 6.15E-07 up no dn up up up 18:3n6+blood 16:0/18:2-PC+blood -0.526315789 -0.566176471 0 serum_fattyacid serum_phospholipids 0.0463 3.24E-06 up no dn no up up 18:3n6+blood 16:0/18:2-PI+blood 0 0 0.500854701 serum_fattyacid serum_phospholipids 0.0463 0.269 up no dn no no no 18:3n6+blood 16:0/18:3-PC+blood 0 0 0.503589744 serum_fattyacid serum_phospholipids 0.0463 0.00216 up no dn no up up 18:3n6+blood 16:0/20:4-PI+blood 0.598496241 0 0.542564103 serum_fattyacid serum_phospholipids 0.0463 0.558 up no dn no no no 18:3n6+blood 16:0/20:5-PG+blood 0 0.590686275 0 serum_fattyacid serum_phospholipids 0.0463 0.00656 up no dn no up no 18:3n6+blood 16:1/16:0-PC+blood -0.466165414 0 0 serum_fattyacid serum_phospholipids 0.0463 0.0215 up no dn no up up 18:3n6+blood 18:0-LPC+blood 0 0.625 0 serum_fattyacid serum_phospholipids 0.0463 0.554 up no dn no no no 18:3n6+blood 18:0/16:0-PC+blood -0.488721805 -0.490196078 0 serum_fattyacid serum_phospholipids 0.0463 9.64E-07 up no dn up up up 18:3n6+blood 18:0/18:1-PG+blood 0 0.732843137 0 serum_fattyacid serum_phospholipids 0.0463 0.000842 up no dn no up no 18:3n6+blood 18:0/18:2-PC+blood -0.526315789 0 0 serum_fattyacid serum_phospholipids 0.0463 1.74E-06 up no dn no up up 18:3n6+blood 18:1-LPC+blood -0.502255639 0 0 serum_fattyacid serum_phospholipids 0.0463 0.179 up no dn no no no 18:3n6+blood 18:1/16:0-PC+blood -0.47518797 -0.578431373 0 serum_fattyacid serum_phospholipids 0.0463 2.43E-05 up no dn no up up 18:3n6+blood 18:1/18:0-PC+blood -0.470676692 0 0 serum_fattyacid serum_phospholipids 0.0463 1.83E-06 up no dn no up up 18:3n6+blood 18:2/16:0-PC+blood -0.615037594 0 0 serum_fattyacid serum_phospholipids 0.0463 8.67E-05 up no dn no up up 18:3n6+blood 18:3-LPC+blood 0 0 0.433162393 serum_fattyacid serum_phospholipids 0.0463 0.147 up no dn no no no 18:3n6+blood 18:3/16:0-PE+blood 0 0 0.514529915 serum_fattyacid serum_phospholipids 0.0463 0.00149 up no dn up up no 18:3n6+blood Acetic acid+stool 0 0 0.455639098 yes serum_fattyacid stool_scfa 0.0463 0.0656 up no dn dn no no 18:3n6+blood Aldosterone synthesis and secretion 0 0.517647059 0 serum_fattyacid kegg 0.0463 NA up no dn no up up 18:3n6+blood Amphetamine addiction 0 0.579411765 0 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood CA+stool 0 0 0.590977444 serum_fattyacid stool_bileacids 0.0463 0.827 up no dn no no no 18:3n6+blood CDCA+stool 0 0 0.606015038 serum_fattyacid stool_bileacids 0.0463 0.663 up no dn no no no 18:3n6+blood Central carbon metabolism in cancer 0 0.608823529 0 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood Cocaine addiction 0 0 0.423076923 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood Colorectal cancer 0 0.547058824 0 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood Endocrine resistance 0 0.588235294 0 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood Fc epsilon RI signaling pathway -0.521052632 0 0 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood FoxO signaling pathway 0 0 -0.416153846 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood Glucagon signaling pathway 0 0.511764706 0 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood "Glycine, serine and threonine metabolism" 0.459649123 0 0 serum_fattyacid kegg 0.0463 NA up no dn no up no 18:3n6+blood Glycolysis / Gluconeogenesis 0.484210526 0 -0.433076923 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood GnRH signaling pathway 0 0.552941176 0 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood Hepatitis C -0.471929825 0 0 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood Inflammatory mediator regulation of TRP channels 0 0.6 0 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood iso-LCA+stool 0 0 -0.529323308 serum_fattyacid stool_bileacids 0.0463 0.72 up no dn no no no 18:3n6+blood L-Phenylalanine+stool -0.582417582 -0.681818182 -0.633082707 serum_fattyacid stool_cometabolism 0.0463 0.398 up no dn no no no 18:3n6+blood L-Tryptophan+stool 0 -0.818181818 -0.503759398 serum_fattyacid stool_cometabolism 0.0463 0.557 up no dn no no no 18:3n6+blood L-Tyrosine+stool -0.642857143 0 -0.583458647 serum_fattyacid stool_cometabolism 0.0463 0.44 up no dn no no no 18:3n6+blood Legionellosis 0 0 -0.496923077 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood Leishmaniasis 0 0 -0.485384615 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood Longevity regulating pathway - multiple species 0 0 -0.473846154 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood Pathogenic Escherichia coli infection 0 -0.567647059 0 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood Phenylacetic acid+stool 0 0 -0.655639098 serum_fattyacid stool_cometabolism 0.0463 0.785 up no dn no no no 18:3n6+blood Phosphatidylinositol signaling system 0 0.535294118 0 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood Prevotella 0 0.495236598 0 acetate-producing serum_fattyacid Genus 0.0463 0.287 up no dn no no no 18:3n6+blood Salmonella infection 0 -0.632352941 0 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood Sphingolipid signaling pathway -0.501754386 0 0 serum_fattyacid kegg 0.0463 NA up no dn no no no 18:3n6+blood TCA+stool 0.629986841 0 0 serum_fattyacid stool_bileacids 0.0463 0.458 up no dn no no no 18:3n6+blood UDCA+stool 0 0 0.518796992 serum_fattyacid stool_bileacids 0.0463 0.266 up no dn no no no 18:3n6+blood Viral carcinogenesis 0 0 0.413076923 serum_fattyacid kegg 0.0463 NA up no dn no no no 2-hydroxyhippuric acid+urine 14:0/18:2-PC+blood -0.558823529 0 0 urine_cometabolism serum_phospholipids 0.215 0.102 no no no no up no 2-hydroxyhippuric acid+urine 16:0/16:0-PC+blood -0.816176471 0 0 urine_cometabolism serum_phospholipids 0.215 0.00079 no no no no up up 2-hydroxyhippuric acid+urine 16:0/18:0-PC+blood -0.671568627 0 0 urine_cometabolism serum_phospholipids 0.215 0.521 no no no no no no 2-hydroxyhippuric acid+urine 16:0/18:1-PC+blood -0.571078431 0 0 urine_cometabolism serum_phospholipids 0.215 6.15E-07 no no no up up up 2-hydroxyhippuric acid+urine 16:0/18:2-PC+blood -0.629901961 0 0 urine_cometabolism serum_phospholipids 0.215 3.24E-06 no no no no up up 2-hydroxyhippuric acid+urine 16:0/18:3-PC+blood -0.546568627 0 0 urine_cometabolism serum_phospholipids 0.215 0.00216 no no no no up up 2-hydroxyhippuric acid+urine 16:0/20:3-PC+blood -0.671568627 0 0 urine_cometabolism serum_phospholipids 0.215 5.43E-06 no no no no up up 2-hydroxyhippuric acid+urine 16:0/22:6-PC+blood -0.723039216 0 0 urine_cometabolism serum_phospholipids 0.215 4.53E-05 no no no no up up 2-hydroxyhippuric acid+urine 16:1/16:0-PC+blood -0.808823529 0 0 urine_cometabolism serum_phospholipids 0.215 0.0215 no no no no up up 2-hydroxyhippuric acid+urine 16:1/16:1-PC+blood -0.784313725 0 0 urine_cometabolism serum_phospholipids 0.215 0.0177 no no no no no up 2-hydroxyhippuric acid+urine 16:1/18:2-PG+blood -0.571078431 0 0 urine_cometabolism serum_phospholipids 0.215 1.40E-08 no no no no up up 2-hydroxyhippuric acid+urine 18:0-LPC+blood 0 0 -0.461038961 urine_cometabolism serum_phospholipids 0.215 0.554 no no no no no no 2-hydroxyhippuric acid+urine 18:0/16:0-PC+blood -0.588235294 0 0 urine_cometabolism serum_phospholipids 0.215 9.64E-07 no no no up up up 2-hydroxyhippuric acid+urine 18:0/18:2-PC+blood -0.730392157 0 0 urine_cometabolism serum_phospholipids 0.215 1.74E-06 no no no no up up 2-hydroxyhippuric acid+urine 18:0/22:6-PA+blood -0.669117647 0 0 urine_cometabolism serum_phospholipids 0.215 0.22 no no no no no no 2-hydroxyhippuric acid+urine 18:0/22:6-PC+blood -0.526960784 0 0 urine_cometabolism serum_phospholipids 0.215 0.0775 no no no no no up 2-hydroxyhippuric acid+urine 18:1-LPE+blood 0.56372549 0 0 urine_cometabolism serum_phospholipids 0.215 0.117 no no no no no no 2-hydroxyhippuric acid+urine 18:1/16:0-PC+blood -0.588235294 0 0 urine_cometabolism serum_phospholipids 0.215 2.43E-05 no no no no up up 2-hydroxyhippuric acid+urine 18:1/18:0-PC+blood -0.742647059 0 0 urine_cometabolism serum_phospholipids 0.215 1.83E-06 no no no no up up 2-hydroxyhippuric acid+urine 18:1/18:1-PC+blood -0.509803922 0 0 urine_cometabolism serum_phospholipids 0.215 1.34E-05 no no no no up up 2-hydroxyhippuric acid+urine 18:1/20:3-PC+blood -0.504901961 0 0 urine_cometabolism serum_phospholipids 0.215 0.00872 no no no no up up 2-hydroxyhippuric acid+urine 18:2-LPA+blood -0.487745098 0 0 urine_cometabolism serum_phospholipids 0.215 0.00684 no no no dn no up 2-hydroxyhippuric acid+urine 18:2/16:0-PC+blood -0.693627451 0 -0.601298701 urine_cometabolism serum_phospholipids 0.215 8.67E-05 no no no no up up 2-hydroxyhippuric acid+urine 18:2/18:2-PC+blood 0 -0.565934066 0 urine_cometabolism serum_phospholipids 0.215 1.98E-05 no no no dn up up 2-hydroxyhippuric acid+urine 18:3n3+blood -0.514705882 0 -0.462337662 urine_cometabolism serum_fattyacid 0.215 0.291 no no no no no no 2-hydroxyhippuric acid+urine 20:0/20:5-PC+blood -0.495098039 0 0 urine_cometabolism serum_phospholipids 0.215 0.882 no no no no no no 2-hydroxyhippuric acid+urine 20:1-LPA+blood -0.495098039 0 0 urine_cometabolism serum_phospholipids 0.215 0.0187 no no no dn dn no 2-hydroxyhippuric acid+urine 20:3/18:0-PC+blood -0.732843137 0 0 urine_cometabolism serum_phospholipids 0.215 0.296 no no no no no no 2-hydroxyhippuric acid+urine 20:5/18:0-PC+blood -0.762254902 0 0 urine_cometabolism serum_phospholipids 0.215 3.97E-06 no no no no up up 2-hydroxyhippuric acid+urine Adipocytokine signaling pathway 0.49122807 0 -0.442307692 urine_cometabolism kegg 0.215 NA no no no no no no 2-hydroxyhippuric acid+urine Butyric acid+stool 0 0 0.475748194 yes urine_cometabolism stool_scfa 0.215 0.102 no no no dn no no 2-hydroxyhippuric acid+urine CDCA+blood 0.517156863 0 0 urine_cometabolism serum_bileacids 0.215 0.506 no no no no no no 2-hydroxyhippuric acid+urine Clostridium -0.550582965 0 0 urine_cometabolism Genus 0.215 0.925 no no no no no no 2-hydroxyhippuric acid+urine Cysteine+blood -0.495098039 0 0 yes urine_cometabolism serum_aminoacids 0.215 1.81E-07 no no no dn up up 2-hydroxyhippuric acid+urine d18:0-24:1-SM+blood 0.585784314 0 0 urine_cometabolism serum_phospholipids 0.215 0.0609 no no no no dn dn 2-hydroxyhippuric acid+urine d18:1-18:0-SM+blood -0.541666667 0 0 urine_cometabolism serum_phospholipids 0.215 0.97 no no no no no no 2-hydroxyhippuric acid+urine DHA+blood -0.536764706 0 0 urine_cometabolism serum_ARA 0.215 0.872 no no no no no no 2-hydroxyhippuric acid+urine Faecalibacterium 0 0.459649123 0 butyrate-producing urine_cometabolism Genus 0.215 0.0039 no no no no dn dn 2-hydroxyhippuric acid+urine GCA+blood 0.75 0 0 yes urine_cometabolism serum_bileacids 0.215 0.16 no no no no no no 2-hydroxyhippuric acid+urine GCDCA+blood 0.769607843 0 0 urine_cometabolism serum_bileacids 0.215 0.31 no no no no no no 2-hydroxyhippuric acid+urine GUDCA+blood 0.553921569 0 0 urine_cometabolism serum_bileacids 0.215 0.0766 no no no no no dn 2-hydroxyhippuric acid+urine HCA+blood 0.540984567 0 0 urine_cometabolism serum_bileacids 0.215 0.544 no no no no no no 2-hydroxyhippuric acid+urine iso-DCA+blood -0.669117647 0 0 urine_cometabolism serum_bileacids 0.215 0.38 no no no no no no 2-hydroxyhippuric acid+urine L-Alanine+blood 0.593137255 0 0 yes urine_cometabolism serum_aminoacids 0.215 0.00138 no no no up up no 2-hydroxyhippuric acid+urine L-Homocystine+blood 0 0 -0.548051948 urine_cometabolism serum_aminoacids 0.215 0.197 no no no no no no 2-hydroxyhippuric acid+urine L-Ornithine+blood 0.50245098 0 0 urine_cometabolism serum_aminoacids 0.215 0.175 no no no no no no 2-hydroxyhippuric acid+urine Longevity regulating pathway 0.456140351 0 0 urine_cometabolism kegg 0.215 NA no no no no no no 2-hydroxyhippuric acid+urine Malaria 0 0 -0.430769231 urine_cometabolism kegg 0.215 NA no no no no no no 2-hydroxyhippuric acid+urine Prevotella 0.487230422 0 0 acetate-producing urine_cometabolism Genus 0.215 0.287 no no no no no no 2-hydroxyhippuric acid+urine Propionic acid+stool 0 -0.833333333 0 yes urine_cometabolism stool_scfa 0.215 0.0436 no no no dn no up 2-hydroxyhippuric acid+urine Small cell lung cancer 0 0 -0.497692308 urine_cometabolism kegg 0.215 NA no no no no no up 2-hydroxyhippuric acid+urine TDCA+blood 0.500563625 0 0 yes urine_cometabolism serum_bileacids 0.215 0.155 no no no no up no 2-hydroxyhippuric acid+urine total_stool_scfa+stool 0 -0.75 0 urine_cometabolism stool_scfa 0.215 0.0534 no no no dn no up 2-hydroxyhippuric acid+urine Transcriptional misregulation in cancer 0 0 -0.405384615 urine_cometabolism kegg 0.215 NA no no no no no no 2-methyl-butyric acid m-C4+blood 12-HEPE+blood 0 0.615824986 0 serum_scfa serum_ARA 0.262 0.312 no no no no no no 2-methyl-butyric acid m-C4+blood 16:0/16:0-PI+blood -0.551879699 0 0 serum_scfa serum_phospholipids 0.262 0.358 no no no no no no 2-methyl-butyric acid m-C4+blood 18:0/18:1-PI+blood 0 0 0.457777778 serum_scfa serum_phospholipids 0.262 0.599 no no no no no no 2-methyl-butyric acid m-C4+blood 18:0/18:2-PI+blood 0 0 0.405128205 serum_scfa serum_phospholipids 0.262 0.179 no no no no no no 2-methyl-butyric acid m-C4+blood 18:0+blood 0.473684211 0 0 serum_scfa serum_fattyacid 0.262 0.344 no no no no no no 2-methyl-butyric acid m-C4+blood 18:1/16:0-PI+blood 0 0 0.431111111 serum_scfa serum_phospholipids 0.262 0.793 no no no no no no 2-methyl-butyric acid m-C4+blood 18:1/18:0-PI+blood 0 0 0.401025641 serum_scfa serum_phospholipids 0.262 0.0931 no no no no no up 2-Oxocarboxylic acid metabolism "Alanine, aspartate and glutamate metabolism" 0 -0.733201581 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism alpha-Linolenic acid metabolism 0.659130435 0 0.506563707 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Amino sugar and nucleotide sugar metabolism 0.556521739 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Aminoacyl-tRNA biosynthesis 0.70173913 0.754940711 0.454311454 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Arginine and proline metabolism 0 -0.672924901 -0.408494208 kegg kegg NA NA no no no no up no 2-Oxocarboxylic acid metabolism Arginine biosynthesis 0 -0.769762846 -0.443500644 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Ascorbate and aldarate metabolism 0.432173913 0.608695652 0.492406692 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism beta-Alanine metabolism 0.842608696 0.52173913 0.496267696 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Biosynthesis of unsaturated fatty acids 0.515652174 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Butanoate metabolism 0.890434783 0.815217391 0.551608752 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Carbon metabolism 0.815652174 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Citrate cycle (TCA cycle) 0.799130435 0.802371542 0.772200772 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Cysteine and methionine metabolism 0 0.626482213 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Drug metabolism - cytochrome P450 0 0.802371542 0.486229086 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Drug metabolism - other enzymes 0.728695652 0.766798419 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Ether lipid metabolism 0 0.425889328 0.412355212 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Fatty acid biosynthesis 0 -0.718379447 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Fatty acid elongation 0.633043478 0 0.432947233 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Folate biosynthesis 0 0.650197628 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Fructose and mannose metabolism 0.686956522 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Galactose metabolism 0.64173913 0 0.455341055 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Glycerolipid metabolism 0 0 0.464607465 kegg kegg NA NA no no no no no up 2-Oxocarboxylic acid metabolism "Glycine, serine and threonine metabolism" 0.456521739 0 -0.476962677 kegg kegg NA NA no no no no up no 2-Oxocarboxylic acid metabolism Glycolysis / Gluconeogenesis 0.780869565 0.537549407 0.465379665 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.514822134 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.767826087 0.801383399 0.648906049 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Glycosaminoglycan degradation 0 0 0.543629344 kegg kegg NA NA no no no no no up 2-Oxocarboxylic acid metabolism Glycosphingolipid biosynthesis - ganglio series 0 0.760869565 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Glyoxylate and dicarboxylate metabolism 0 -0.770750988 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Histidine metabolism 0.512173913 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Lysine degradation 0 0.440711462 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Mannose type O-glycan biosynthesis 0 0.423913043 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Metabolism of xenobiotics by cytochrome P450 0.442608696 0.787549407 0.47979408 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism N-Glycan biosynthesis 0 0.830039526 0.457915058 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Nicotinate and nicotinamide metabolism 0 -0.766798419 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Nitrogen metabolism 0 -0.849802372 -0.602316602 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism One carbon pool by folate 0.407826087 0.712450593 0.607979408 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Other glycan degradation 0 0 0.533333333 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Oxidative phosphorylation -0.526086957 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Pantothenate and CoA biosynthesis 0 -0.610671937 0 kegg kegg NA NA no no no no no dn 2-Oxocarboxylic acid metabolism Pentose and glucuronate interconversions 0.524347826 0.874505929 0.813899614 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Pentose phosphate pathway 0 -0.504940711 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Phenylalanine metabolism 0.809565217 0.787549407 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Porphyrin and chlorophyll metabolism 0.420869565 0 -0.445817246 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Primary bile acid biosynthesis 0.620869565 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Propanoate metabolism 0.46173913 0.551383399 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Purine metabolism 0 0 -0.415958816 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Pyrimidine metabolism 0.586956522 0.685770751 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Pyruvate metabolism 0.551304348 0.624505929 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Retinol metabolism 0.536521739 0.572134387 0.513256113 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Selenocompound metabolism 0 0 0.403603604 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Starch and sucrose metabolism 0 -0.563241107 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Steroid biosynthesis 0 0 0.51042471 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Steroid hormone biosynthesis 0.463478261 0.480237154 0.446074646 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Sulfur metabolism 0.508695652 0 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Synthesis and degradation of ketone bodies 0.449565217 0.564229249 0.457400257 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Terpenoid backbone biosynthesis 0 0.457509881 0.530759331 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Thiamine metabolism 0 0.454545455 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Tryptophan metabolism 0.833913043 0.646245059 0.468725869 kegg kegg NA NA no no no no up no 2-Oxocarboxylic acid metabolism Tyrosine metabolism 0.696521739 0.610671937 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.62 0.733201581 0 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism "Valine, leucine and isoleucine degradation" 0.782608696 0.806324111 0.593822394 kegg kegg NA NA no no no no no no 2-Oxocarboxylic acid metabolism Various types of N-glycan biosynthesis 0 0.807312253 0.540797941 kegg kegg NA NA no no no no no no 20-HDOHE+blood 12-HEPE+blood 0.479990784 0 0 serum_ARA serum_ARA 0.205 0.312 no no no no no no 20:0-LPC+blood 12-ketoDCA+blood 0 0.589479532 -0.45456157 serum_phospholipids serum_bileacids 0.199 0.517 no no no no no no 20:0-LPC+blood "12,13-EPOME+blood" 0.529725363 -0.504817556 0 serum_phospholipids serum_ARA 0.199 0.901 no no no no no no 20:0-LPC+blood 14:0/16:0-PC+blood -0.572932331 0 0 serum_phospholipids serum_phospholipids 0.199 0.0358 no no no no up no 20:0-LPC+blood 16:0/18:0-PC+blood 0 0 0.428376068 serum_phospholipids serum_phospholipids 0.199 0.521 no no no no no no 20:0-LPC+blood 16:1/16:0-PC+blood 0 0 -0.497435897 serum_phospholipids serum_phospholipids 0.199 0.0215 no no no no up up 20:0-LPC+blood 16:1/16:1-PC+blood 0 0 -0.583589744 serum_phospholipids serum_phospholipids 0.199 0.0177 no no no no no up 20:0-LPC+blood 18:0-LPC+blood 0 0.720588235 0.617777778 serum_phospholipids serum_phospholipids 0.199 0.554 no no no no no no 20:0-LPC+blood 18:0-LPE+blood 0 0 0.433162393 serum_phospholipids serum_phospholipids 0.199 0.491 no no no no no no 20:0-LPC+blood 18:0/18:0-PC+blood 0 0 0.463247863 serum_phospholipids serum_phospholipids 0.199 0.426 no no no no no no 20:0-LPC+blood 18:0/18:1-PC+blood 0 0 0.484444444 serum_phospholipids serum_phospholipids 0.199 0.393 no no no no no no 20:0-LPC+blood 18:0/20:2-PC+blood 0 0 0.658119658 serum_phospholipids serum_phospholipids 0.199 0.733 no no no no no no 20:0-LPC+blood 18:1-LPC+blood 0 0.522058824 0.544615385 serum_phospholipids serum_phospholipids 0.199 0.179 no no no no no no 20:0-LPC+blood 18:1-LPE+blood 0 0 0.496752137 serum_phospholipids serum_phospholipids 0.199 0.117 no no no no no no 20:0-LPC+blood 18:1/18:1-PI+blood 0.586466165 0 0.432478632 serum_phospholipids serum_phospholipids 0.199 0.111 no no no dn no no 20:0-LPC+blood 18:1/18:2-PI+blood 0 0 0.412649573 serum_phospholipids serum_phospholipids 0.199 0.0164 no no no dn no up 20:0-LPC+blood 18:1/20:3-PC+blood 0 0.580882353 0 serum_phospholipids serum_phospholipids 0.199 0.00872 no no no no up up 20:0-LPC+blood 18:2-LPC+blood 0 0 0.419487179 serum_phospholipids serum_phospholipids 0.199 0.00743 no no no dn no up 20:0-LPC+blood 18:2-LPE+blood 0 0 0.414017094 serum_phospholipids serum_phospholipids 0.199 0.112 no no no no no no 20:0-LPC+blood 18:2/18:1-PC+blood 0 0 0.478974359 serum_phospholipids serum_phospholipids 0.199 2.30E-05 no no no dn up up 20:0-LPC+blood 18:2/18:2-PC+blood 0 0 0.491282051 serum_phospholipids serum_phospholipids 0.199 1.98E-05 no no no dn up up 20:0-LPC+blood 18:2/20:4-PC+blood 0 0.49754902 0.488547009 serum_phospholipids serum_phospholipids 0.199 0.0145 no no no no no up 20:0-LPC+blood 18:3n3+blood 0 -0.551470588 0 serum_phospholipids serum_fattyacid 0.199 0.291 no no no no no no 20:0-LPC+blood 20:0+blood 0 0.637254902 0 yes serum_phospholipids serum_fattyacid 0.199 0.000278 no no no dn no up 20:0-LPE+blood 16:0/16:0-PI+blood 0.598496241 0 0 serum_phospholipids serum_phospholipids 0.0615 0.358 no no up no no no 20:0-LPE+blood 16:0/16:1-PI+blood 0 0 -0.416752137 serum_phospholipids serum_phospholipids 0.0615 0.262 no no up no no no 20:0-LPE+blood 16:0/18:0-PC+blood 0 0 0.504957265 serum_phospholipids serum_phospholipids 0.0615 0.521 no no up no no no 20:0-LPE+blood 16:0/18:0-PS+blood 0 0 -0.434529915 serum_phospholipids serum_phospholipids 0.0615 0.377 no no up no no no 20:0-LPE+blood 16:0/18:1-PC+blood -0.67518797 0 -0.42017094 serum_phospholipids serum_phospholipids 0.0615 6.15E-07 no no up up up up 20:0-LPE+blood 16:0/18:1-PE+blood 0.577443609 0 0 serum_phospholipids serum_phospholipids 0.0615 0.000107 no no up up up no 20:0-LPE+blood 16:0/18:2-PC+blood -0.685714286 0 0 serum_phospholipids serum_phospholipids 0.0615 3.24E-06 no no up no up up 20:0-LPE+blood 16:0/18:2-PI+blood 0.612030075 0 0 serum_phospholipids serum_phospholipids 0.0615 0.269 no no up no no no 20:0-LPE+blood 16:0/20:3-PC+blood -0.464661654 0 0 serum_phospholipids serum_phospholipids 0.0615 5.43E-06 no no up no up up 20:0-LPE+blood 16:0/20:4-PC+blood -0.460150376 -0.504901961 0 serum_phospholipids serum_phospholipids 0.0615 0.0262 no no up no up no 20:0-LPE+blood 16:0/20:4-PE+blood 0 0 -0.434529915 serum_phospholipids serum_phospholipids 0.0615 0.00139 no no up up up no 20:0-LPE+blood 16:0/20:4-PI+blood 0.484210526 0 0 serum_phospholipids serum_phospholipids 0.0615 0.558 no no up no no no 20:0-LPE+blood 16:0/22:6-PC+blood -0.545864662 0 0 serum_phospholipids serum_phospholipids 0.0615 4.53E-05 no no up no up up 20:0-LPE+blood 16:1/16:0-PC+blood -0.586466165 0 0 serum_phospholipids serum_phospholipids 0.0615 0.0215 no no up no up up 20:0-LPE+blood 16:1/16:1-PC+blood -0.545864662 0 0 serum_phospholipids serum_phospholipids 0.0615 0.0177 no no up no no up 20:0-LPE+blood 16:1/18:1-PG+blood 0 0 -0.571965812 serum_phospholipids serum_phospholipids 0.0615 3.21E-05 no no up no up up 20:0-LPE+blood 18:0-LPC+blood 0 0.549019608 0.463931624 serum_phospholipids serum_phospholipids 0.0615 0.554 no no up no no no 20:0-LPE+blood 18:0-LPE+blood 0 0.566176471 0 serum_phospholipids serum_phospholipids 0.0615 0.491 no no up no no no 20:0-LPE+blood 18:0/16:0-PC+blood -0.657142857 0 -0.465982906 serum_phospholipids serum_phospholipids 0.0615 9.64E-07 no no up up up up 20:0-LPE+blood 18:0/18:0-PE+blood 0.461654135 0 0 serum_phospholipids serum_phospholipids 0.0615 0.00896 no no up up up no 20:0-LPE+blood 18:0/18:0-PS+blood 0 0 -0.463931624 serum_phospholipids serum_phospholipids 0.0615 0.00617 no no up no up no 20:0-LPE+blood 18:0/18:1-PE+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.0615 0.00716 no no up up up no 20:0-LPE+blood 18:0/18:2-PC+blood -0.652631579 0 0 serum_phospholipids serum_phospholipids 0.0615 1.74E-06 no no up no up up 20:0-LPE+blood 18:0/18:2-PI+blood 0.541353383 0 0 serum_phospholipids serum_phospholipids 0.0615 0.179 no no up no no no 20:0-LPE+blood 18:0/20:2-PC+blood 0 0 0.494017094 serum_phospholipids serum_phospholipids 0.0615 0.733 no no up no no no 20:0-LPE+blood 18:0/20:4-PC+blood -0.520300752 0 0 serum_phospholipids serum_phospholipids 0.0615 0.454 no no up no no no 20:0-LPE+blood 18:0/20:5-PC+blood -0.613533835 0 0 serum_phospholipids serum_phospholipids 0.0615 0.17 no no up no no no 20:0-LPE+blood 18:0/22:6-PA+blood 0 0 -0.446153846 serum_phospholipids serum_phospholipids 0.0615 0.22 no no up no no no 20:0-LPE+blood 18:1-LPC+blood 0 0 0.453675214 serum_phospholipids serum_phospholipids 0.0615 0.179 no no up no no no 20:0-LPE+blood 18:1/16:0-PC+blood -0.672180451 0 0 serum_phospholipids serum_phospholipids 0.0615 2.43E-05 no no up no up up 20:0-LPE+blood 18:1/16:0-PI+blood 0.545864662 0 0 serum_phospholipids serum_phospholipids 0.0615 0.793 no no up no no no 20:0-LPE+blood 18:1/16:1-PE+blood 0.452631579 0 0 serum_phospholipids serum_phospholipids 0.0615 0.000184 no no up up up no 20:0-LPE+blood 18:1/18:0-PC+blood -0.693233083 0 0 serum_phospholipids serum_phospholipids 0.0615 1.83E-06 no no up no up up 20:0-LPE+blood 18:1/18:0-PI+blood 0 0.68627451 0 serum_phospholipids serum_phospholipids 0.0615 0.0931 no no up no no up 20:0-LPE+blood 18:1/18:0-PS+blood -0.448120301 0 0 serum_phospholipids serum_phospholipids 0.0615 0.193 no no up no no no 20:0-LPE+blood 18:1/18:1-PI+blood 0 0.509803922 0 serum_phospholipids serum_phospholipids 0.0615 0.111 no no up dn no no 20:0-LPE+blood 18:1/18:2-PE+blood 0.520300752 0 0 serum_phospholipids serum_phospholipids 0.0615 0.000293 no no up up up no 20:0-LPE+blood 18:1/18:2-PI+blood 0 0.539215686 0.484444444 serum_phospholipids serum_phospholipids 0.0615 0.0164 no no up dn no up 20:0-LPE+blood 18:2-LPC+blood 0 0 0.515213675 serum_phospholipids serum_phospholipids 0.0615 0.00743 no no up dn no up 20:0-LPE+blood 18:2/16:0-PC+blood -0.488721805 0 0 serum_phospholipids serum_phospholipids 0.0615 8.67E-05 no no up no up up 20:0-LPE+blood 18:2/18:1-PC+blood 0 0 0.732649573 serum_phospholipids serum_phospholipids 0.0615 2.30E-05 no no up dn up up 20:0-LPE+blood 18:2/18:2-PC+blood 0 0 0.731282051 serum_phospholipids serum_phospholipids 0.0615 1.98E-05 no no up dn up up 20:0-LPE+blood 18:2/20:4-PC+blood 0 0 0.424957265 serum_phospholipids serum_phospholipids 0.0615 0.0145 no no up no no up 20:0-LPE+blood 18:3/18:2-PC+blood 0 0 0.605470085 serum_phospholipids serum_phospholipids 0.0615 0.0394 no no up no no up 20:0-LPE+blood 20:0-LPC+blood 0 0.509803922 0.574700855 serum_phospholipids serum_phospholipids 0.0615 0.199 no no up no no no 20:0/20:4-PE+blood 12-HEPE+blood 0 0 -0.438705301 serum_phospholipids serum_ARA 0.00128 0.312 up up no no no no 20:0/20:4-PE+blood 14:0-LPC+blood 0 0.659313725 0 serum_phospholipids serum_phospholipids 0.00128 0.00689 up up no up up no 20:0/20:4-PE+blood 14:0/18:0-PC+blood 0 0.539215686 0 serum_phospholipids serum_phospholipids 0.00128 0.00289 up up no up up no 20:0/20:4-PE+blood 14:0/18:2-PC+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.00128 0.102 up up no no up no 20:0/20:4-PE+blood 14:0/20:4-PC+blood 0 0 0.470769231 serum_phospholipids serum_phospholipids 0.00128 0.486 up up no no no no 20:0/20:4-PE+blood 14:1/18:2-PG+blood 0 0 0.44957265 serum_phospholipids serum_phospholipids 0.00128 0.00259 up up no no up up 20:0/20:4-PE+blood 16:0/16:0-PI+blood 0 0.517156863 0 serum_phospholipids serum_phospholipids 0.00128 0.358 up up no no no no 20:0/20:4-PE+blood 16:0/16:1-PC+blood 0 0.512254902 0 serum_phospholipids serum_phospholipids 0.00128 0.00283 up up no up up no 20:0/20:4-PE+blood 16:0/16:1-PI+blood 0 0.522058824 0 serum_phospholipids serum_phospholipids 0.00128 0.262 up up no no no no 20:0/20:4-PE+blood 16:0/18:0-PS+blood 0.49924812 0 0 serum_phospholipids serum_phospholipids 0.00128 0.377 up up no no no no 20:0/20:4-PE+blood 16:0/18:1-PC+blood 0 -0.556372549 0 serum_phospholipids serum_phospholipids 0.00128 6.15E-07 up up no up up up 20:0/20:4-PE+blood 16:0/18:1-PE+blood 0.538345865 0 0 serum_phospholipids serum_phospholipids 0.00128 0.000107 up up no up up no 20:0/20:4-PE+blood 16:0/18:2-PC+blood 0 -0.544117647 -0.419487179 serum_phospholipids serum_phospholipids 0.00128 3.24E-06 up up no no up up 20:0/20:4-PE+blood 16:0/18:2-PI+blood 0 0.732843137 0 serum_phospholipids serum_phospholipids 0.00128 0.269 up up no no no no 20:0/20:4-PE+blood 16:0/20:4-PC+blood 0 -0.524509804 0 serum_phospholipids serum_phospholipids 0.00128 0.0262 up up no no up no 20:0/20:4-PE+blood 16:0/20:4-PE+blood 0.556390977 0 0.401025641 serum_phospholipids serum_phospholipids 0.00128 0.00139 up up no up up no 20:0/20:4-PE+blood 16:0/20:4-PI+blood 0 0.590686275 0 serum_phospholipids serum_phospholipids 0.00128 0.558 up up no no no no 20:0/20:4-PE+blood 16:0/22:6-PC+blood -0.458646617 -0.656862745 -0.442051282 serum_phospholipids serum_phospholipids 0.00128 4.53E-05 up up no no up up 20:0/20:4-PE+blood 16:0/22:6-PE+blood 0.532330827 0 0.434529915 serum_phospholipids serum_phospholipids 0.00128 0.000934 up up no up up no 20:0/20:4-PE+blood 16:1/16:0-PC+blood 0 -0.62745098 -0.435897436 serum_phospholipids serum_phospholipids 0.00128 0.0215 up up no no up up 20:0/20:4-PE+blood 18:0-LPE+blood 0 0 0.519316239 serum_phospholipids serum_phospholipids 0.00128 0.491 up up no no no no 20:0/20:4-PE+blood 18:0/16:0-PC+blood 0 -0.595588235 0 serum_phospholipids serum_phospholipids 0.00128 9.64E-07 up up no up up up 20:0/20:4-PE+blood 18:0/18:0-PE+blood 0.578947368 0.522058824 0.715555556 serum_phospholipids serum_phospholipids 0.00128 0.00896 up up no up up no 20:0/20:4-PE+blood 18:0/18:0-PS+blood 0.478195489 0 0 serum_phospholipids serum_phospholipids 0.00128 0.00617 up up no no up no 20:0/20:4-PE+blood 18:0/18:1-PE+blood 0.571428571 0.612745098 0.66017094 serum_phospholipids serum_phospholipids 0.00128 0.00716 up up no up up no 20:0/20:4-PE+blood 18:0/18:1-PG+blood 0.586466165 0.531862745 0.441367521 serum_phospholipids serum_phospholipids 0.00128 0.000842 up up no no up no 20:0/20:4-PE+blood 18:0/18:2-PI+blood 0.481203008 0 0 serum_phospholipids serum_phospholipids 0.00128 0.179 up up no no no no 20:0/20:4-PE+blood 18:0/20:4-PC+blood 0 -0.519607843 0 serum_phospholipids serum_phospholipids 0.00128 0.454 up up no no no no 20:0/20:4-PE+blood 18:0/20:5-PC+blood 0 -0.541666667 0 serum_phospholipids serum_phospholipids 0.00128 0.17 up up no no no no 20:0/20:4-PE+blood 18:0/22:6-PC+blood -0.551879699 0 -0.444786325 serum_phospholipids serum_phospholipids 0.00128 0.0775 up up no no no up 20:0/20:4-PE+blood 18:1/16:0-PC+blood 0 -0.544117647 -0.432478632 serum_phospholipids serum_phospholipids 0.00128 2.43E-05 up up no no up up 20:0/20:4-PE+blood 18:1/16:0-PE+blood 0.62556391 0 0.702564103 serum_phospholipids serum_phospholipids 0.00128 0.000182 up up no up up no 20:0/20:4-PE+blood 18:1/18:0-PE+blood 0.473684211 0.580882353 0.574700855 serum_phospholipids serum_phospholipids 0.00128 1.39E-06 up up no up up no 20:0/20:4-PE+blood 18:1/18:1-PE+blood 0.554887218 0.546568627 0.620512821 serum_phospholipids serum_phospholipids 0.00128 1.03E-05 up up no up up no 20:0/20:4-PE+blood 18:1/18:2-PE+blood 0.497744361 0.519607843 0.536410256 serum_phospholipids serum_phospholipids 0.00128 0.000293 up up no up up no 20:0/20:4-PE+blood 18:1/20:4-PC+blood 0 -0.519607843 0 serum_phospholipids serum_phospholipids 0.00128 0.582 up up no no no no 20:0/20:4-PE+blood 18:1/20:4-PE+blood 0.590977444 0 0.663589744 serum_phospholipids serum_phospholipids 0.00128 0.0578 up up no up no no 20:0/20:4-PE+blood 18:2/18:2-PS+blood 0.487218045 0 0 serum_phospholipids serum_phospholipids 0.00128 0.00674 up up no up up no 20:0/20:4-PE+blood 18:3/16:0-PE+blood 0.481203008 0.600490196 0.439316239 serum_phospholipids serum_phospholipids 0.00128 0.00149 up up no up up no 20:0/20:4-PE+blood 18:3n6+blood 0 0.556372549 0 serum_phospholipids serum_fattyacid 0.00128 0.0463 up up no up no dn 20:0/20:5-PC+blood 14:0-LPC+blood -0.583458647 0 0 serum_phospholipids serum_phospholipids 0.882 0.00689 no no no up up no 20:0/20:5-PC+blood 16:0/14:0-PC+blood 0 0 0.452307692 serum_phospholipids serum_phospholipids 0.882 0.0206 no no no no up up 20:0/20:5-PC+blood 16:0/16:1-PI+blood -0.560902256 0 0 serum_phospholipids serum_phospholipids 0.882 0.262 no no no no no no 20:0/20:5-PC+blood 16:0/18:1-PC+blood 0.506766917 0 0 serum_phospholipids serum_phospholipids 0.882 6.15E-07 no no no up up up 20:0/20:5-PC+blood 16:0/18:2-PC+blood 0 0 0.408547009 serum_phospholipids serum_phospholipids 0.882 3.24E-06 no no no no up up 20:0/20:5-PC+blood 16:0/18:2-PI+blood -0.497744361 0 0 serum_phospholipids serum_phospholipids 0.882 0.269 no no no no no no 20:0/20:5-PC+blood 16:0/20:4-PC+blood 0.454135338 0 0.615042735 serum_phospholipids serum_phospholipids 0.882 0.0262 no no no no up no 20:0/20:5-PC+blood 16:0/20:5-PG+blood 0.810526316 0 0 serum_phospholipids serum_phospholipids 0.882 0.00656 no no no no up no 20:0/20:5-PC+blood 16:0/22:6-PC+blood 0 0.56127451 0 serum_phospholipids serum_phospholipids 0.882 4.53E-05 no no no no up up 20:0/20:5-PC+blood 16:1/16:0-PC+blood 0.476691729 0.490196078 0 serum_phospholipids serum_phospholipids 0.882 0.0215 no no no no up up 20:0/20:5-PC+blood 16:1/16:1-PC+blood 0.744360902 0 0 serum_phospholipids serum_phospholipids 0.882 0.0177 no no no no no up 20:0/20:5-PC+blood 16:1/18:1-PG+blood 0.661654135 0 -0.500854701 serum_phospholipids serum_phospholipids 0.882 3.21E-05 no no no no up up 20:0/20:5-PC+blood 16:1/18:2-PG+blood 0.581954887 0 -0.461880342 serum_phospholipids serum_phospholipids 0.882 1.40E-08 no no no no up up 20:0/20:5-PC+blood 18:0/16:0-PC+blood 0.542857143 0 0 serum_phospholipids serum_phospholipids 0.882 9.64E-07 no no no up up up 20:0/20:5-PC+blood 18:0/18:2-PC+blood 0 0 0.484444444 serum_phospholipids serum_phospholipids 0.882 1.74E-06 no no no no up up 20:0/20:5-PC+blood 18:0/20:3-PI+blood 0.521804511 0 0 serum_phospholipids serum_phospholipids 0.882 0.377 no no no no no no 20:0/20:5-PC+blood 18:0/20:4-PC+blood 0.637593985 0.615196078 0.711452991 serum_phospholipids serum_phospholipids 0.882 0.454 no no no no no no 20:0/20:5-PC+blood 18:0/20:4-PI+blood 0.733834586 0 0 serum_phospholipids serum_phospholipids 0.882 0.167 no no no no no no 20:0/20:5-PC+blood 18:0/20:5-PC+blood 0 0.593137255 0.809230769 serum_phospholipids serum_phospholipids 0.882 0.17 no no no no no no 20:0/20:5-PC+blood 18:0/22:6-PA+blood 0.448120301 0 0 serum_phospholipids serum_phospholipids 0.882 0.22 no no no no no no 20:0/20:5-PC+blood 18:0/22:6-PC+blood 0 0.742647059 0.441367521 serum_phospholipids serum_phospholipids 0.882 0.0775 no no no no no up 20:0/20:5-PC+blood 18:0/22:6-PI+blood 0 0.590686275 0 serum_phospholipids serum_phospholipids 0.882 0.425 no no no no no no 20:0/20:5-PC+blood 18:1-LPE+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.882 0.117 no no no no no no 20:0/20:5-PC+blood 18:1/16:0-PC+blood 0 0 0.413333333 serum_phospholipids serum_phospholipids 0.882 2.43E-05 no no no no up up 20:0/20:5-PC+blood 18:1/18:0-PC+blood 0 0 0.446153846 serum_phospholipids serum_phospholipids 0.882 1.83E-06 no no no no up up 20:0/20:5-PC+blood 18:1/18:0-PS+blood 0.723308271 0 0 serum_phospholipids serum_phospholipids 0.882 0.193 no no no no no no 20:0/20:5-PC+blood 18:1/18:1-PG+blood 0.523308271 0 0 serum_phospholipids serum_phospholipids 0.882 0.00352 no no no no up up 20:0/20:5-PC+blood 18:1/18:2-PE+blood 0 -0.509803922 0 serum_phospholipids serum_phospholipids 0.882 0.000293 no no no up up no 20:0/20:5-PC+blood 18:1/18:2-PG+blood 0.529323308 0 0 serum_phospholipids serum_phospholipids 0.882 5.58E-07 no no no no up up 20:0/20:5-PC+blood 18:1/20:3-PC+blood 0 0 0.601367521 serum_phospholipids serum_phospholipids 0.882 0.00872 no no no no up up 20:0/20:5-PC+blood 18:1/20:4-PC+blood 0.763909774 0.715686275 0.695726496 serum_phospholipids serum_phospholipids 0.882 0.582 no no no no no no 20:0/20:5-PC+blood 18:1/20:4-PI+blood 0 0 0.591111111 serum_phospholipids serum_phospholipids 0.882 0.192 no no no no no no 20:0/20:5-PC+blood 18:2-LPC+blood 0 -0.590686275 0 serum_phospholipids serum_phospholipids 0.882 0.00743 no no no dn no up 20:0/20:5-PC+blood 18:2-LPE+blood -0.52481203 -0.637254902 0 serum_phospholipids serum_phospholipids 0.882 0.112 no no no no no no 20:0/20:5-PC+blood 18:2/18:1-PC+blood 0 -0.632352941 0 serum_phospholipids serum_phospholipids 0.882 2.30E-05 no no no dn up up 20:0/20:5-PC+blood 18:2/18:2-PC+blood 0 -0.615196078 0 serum_phospholipids serum_phospholipids 0.882 1.98E-05 no no no dn up up 20:0/20:5-PC+blood 18:2/18:2-PS+blood 0 0 -0.542564103 serum_phospholipids serum_phospholipids 0.882 0.00674 no no no up up no 20:0/20:5-PC+blood 18:2/20:4-PC+blood 0 0 0.501538462 serum_phospholipids serum_phospholipids 0.882 0.0145 no no no no no up 20:0/20:5-PC+blood 18:2n6c+blood 0 -0.659313725 0 serum_phospholipids serum_fattyacid 0.882 0.15 no no no no no no 20:0/20:5-PC+blood 18:3-LPC+blood -0.596992481 0 0 serum_phospholipids serum_phospholipids 0.882 0.147 no no no no no no 20:0/20:5-PC+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.44962406 serum_phospholipids stool_cometabolism 0.882 0.33 no no no no no no 20:0/20:5-PC+blood Alzheimer disease 0 0 -0.444615385 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood AMPK signaling pathway -0.461403509 0 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Biosynthesis of amino acids 0 0 0.421538462 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Biosynthesis of cofactors -0.58245614 0 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood CA+stool 0 0 -0.473684211 serum_phospholipids stool_bileacids 0.882 0.827 no no no no no no 20:0/20:5-PC+blood cAMP signaling pathway 0 -0.523529412 0 yes serum_phospholipids kegg 0.882 NA no no no no up up 20:0/20:5-PC+blood Cardiac muscle contraction 0 0 -0.431538462 serum_phospholipids kegg 0.882 NA no no no no no up 20:0/20:5-PC+blood Clostridium 0 0 -0.513848839 serum_phospholipids Genus 0.882 0.925 no no no no no no 20:0/20:5-PC+blood Diabetic cardiomyopathy 0 0 -0.456153846 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Epstein-Barr virus infection 0 -0.647058824 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Fc gamma R-mediated phagocytosis 0.478947368 0 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood "Glycine, serine and threonine metabolism" -0.571929825 0 0 serum_phospholipids kegg 0.882 NA no no no no up no 20:0/20:5-PC+blood Herpes simplex virus 1 infection 0 -0.611764706 -0.443076923 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Human cytomegalovirus infection 0 -0.676470588 0 serum_phospholipids kegg 0.882 NA no no no no no dn 20:0/20:5-PC+blood Human immunodeficiency virus 1 infection 0 -0.670588235 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Human T-cell leukemia virus 1 infection 0 -0.652941176 -0.423076923 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood IL-17 signaling pathway 0.464912281 0 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.664705882 0 serum_phospholipids kegg 0.882 NA no no no no no dn 20:0/20:5-PC+blood Lachnospira 0 0 0.631507775 butyrate-producing serum_phospholipids Genus 0.882 0.279 no no no no no no 20:0/20:5-PC+blood Lipid and atherosclerosis 0.529824561 0 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Long-term potentiation 0 0 -0.423846154 serum_phospholipids kegg 0.882 NA no no no no no up 20:0/20:5-PC+blood Mitophagy - animal -0.614035088 0 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood mTOR signaling pathway -0.463157895 0 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood NOD-like receptor signaling pathway 0.528070175 0 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Non-alcoholic fatty liver disease 0 -0.544117647 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Oxidative phosphorylation 0 0 -0.45 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Parabacteroides 0 0.490196078 0 serum_phospholipids Genus 0.882 4.19E-05 no no no no up up 20:0/20:5-PC+blood Peroxisome 0 0 0.504615385 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Porphyrin and chlorophyll metabolism -0.487719298 0 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Prevotella -0.510033147 0 0 acetate-producing serum_phospholipids Genus 0.882 0.287 no no no no no no 20:0/20:5-PC+blood Prion disease 0 0 -0.522307692 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Proteoglycans in cancer -0.598245614 0 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Ras signaling pathway 0 0 -0.466923077 yes serum_phospholipids kegg 0.882 NA no no no no up up 20:0/20:5-PC+blood Retrograde endocannabinoid signaling 0 0 -0.616923077 serum_phospholipids kegg 0.882 NA no no no no no up 20:0/20:5-PC+blood Shigellosis -0.487719298 -0.526470588 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Systemic lupus erythematosus 0.545614035 0 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood TCA+stool 0 -0.672727273 0 serum_phospholipids stool_bileacids 0.882 0.458 no no no no no no 20:0/20:5-PC+blood Th1 and Th2 cell differentiation 0 0 -0.451538462 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Th17 cell differentiation 0 0 -0.409230769 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Thermogenesis 0 0 -0.496153846 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood Tuberculosis 0.468421053 0 0 serum_phospholipids kegg 0.882 NA no no no no no dn 20:0/20:5-PC+blood Ubiquitin mediated proteolysis -0.610526316 0 0 serum_phospholipids kegg 0.882 NA no no no no no no 20:0/20:5-PC+blood UDCA+stool 0 0 -0.482706767 serum_phospholipids stool_bileacids 0.882 0.266 no no no no no no 20:0+blood "12,13-EPOME+blood" 0 -0.49980696 0 yes serum_fattyacid serum_ARA 0.000278 0.901 dn no up no no no 20:0+blood 15-HETE+blood 0 -0.527753557 0 yes serum_fattyacid serum_ARA 0.000278 0.819 dn no up no no no 20:0+blood 16:0-LPC+blood 0 0 0.499487179 yes serum_fattyacid serum_phospholipids 0.000278 0.00456 dn no up up up no 20:0+blood 16:0-LPE+blood 0 0 0.517948718 yes serum_fattyacid serum_phospholipids 0.000278 0.0711 dn no up up up no 20:0+blood 16:0/16:0-PI+blood -0.470676692 0 0 yes serum_fattyacid serum_phospholipids 0.000278 0.358 dn no up no no no 20:0+blood 16:0/16:1-PI+blood 0 0 0.503589744 yes serum_fattyacid serum_phospholipids 0.000278 0.262 dn no up no no no 20:0+blood 16:0/18:2-PI+blood -0.446616541 0 0.498119658 yes serum_fattyacid serum_phospholipids 0.000278 0.269 dn no up no no no 20:0+blood 16:0/20:4-PI+blood 0 0 0.432478632 yes serum_fattyacid serum_phospholipids 0.000278 0.558 dn no up no no no 20:0+blood 18:0/18:0-PS+blood -0.566917293 0 0 yes serum_fattyacid serum_phospholipids 0.000278 0.00617 dn no up no up no 20:0+blood 18:0/22:6-PC+blood -0.473684211 0 0 yes serum_fattyacid serum_phospholipids 0.000278 0.0775 dn no up no no up 20:0+blood 18:0/22:6-PE+blood -0.466165414 0 0 yes serum_fattyacid serum_phospholipids 0.000278 0.00022 dn no up up up no 20:0+blood 18:0/22:6-PI+blood -0.660150376 0 0 yes serum_fattyacid serum_phospholipids 0.000278 0.425 dn no up no no no 20:0+blood 18:1-LPC+blood 0.622556391 0 0 yes serum_fattyacid serum_phospholipids 0.000278 0.179 dn no up no no no 20:0+blood 18:1/18:1-PC+blood 0.520300752 0 0 yes serum_fattyacid serum_phospholipids 0.000278 1.34E-05 dn no up no up up 20:0+blood 18:1/20:3-PC+blood 0 0.531862745 0 yes serum_fattyacid serum_phospholipids 0.000278 0.00872 dn no up no up up 20:0+blood 18:2-LPA+blood 0 -0.553921569 0 yes serum_fattyacid serum_phospholipids 0.000278 0.00684 dn no up dn no up 20:0+blood 18:2-LPC+blood 0.470676692 0 0 yes serum_fattyacid serum_phospholipids 0.000278 0.00743 dn no up dn no up 20:0+blood 18:2/18:1-PC+blood 0.566917293 0 0 yes serum_fattyacid serum_phospholipids 0.000278 2.30E-05 dn no up dn up up 20:0+blood 18:2/18:2-PC+blood 0.633082707 0 0 yes serum_fattyacid serum_phospholipids 0.000278 1.98E-05 dn no up dn up up 20:0+blood 18:2/20:4-PC+blood 0 0.529411765 0 yes serum_fattyacid serum_phospholipids 0.000278 0.0145 dn no up no no up 20:0+blood 18:3-LPC+blood 0 -0.551470588 0.428376068 yes serum_fattyacid serum_phospholipids 0.000278 0.147 dn no up no no no 20:0+blood 18:3/16:0-PE+blood 0 0 0.421538462 yes serum_fattyacid serum_phospholipids 0.000278 0.00149 dn no up up up no 20:0+blood 18:3n3+blood 0 -0.553921569 0 yes serum_fattyacid serum_fattyacid 0.000278 0.291 dn no up no no no 20:0+blood Aldosterone synthesis and secretion 0 0 0.44 yes serum_fattyacid kegg 0.000278 NA dn no up no up up 20:0+blood Alistipes 0 0.486817995 0 yes serum_fattyacid Genus 0.000278 0.0114 dn no up no up no 20:0+blood Amyotrophic lateral sclerosis 0.51754386 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Anaerostipes -0.505187765 0 0 yes butyrate-producing serum_fattyacid Genus 0.000278 0.568 dn no up no no no 20:0+blood Asthma 0 0 -0.466923077 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood B cell receptor signaling pathway 0 0 0.401538462 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood C-type lectin receptor signaling pathway 0 0 0.406923077 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Calcium signaling pathway 0 0 0.514615385 yes serum_fattyacid kegg 0.000278 NA dn no up no up up 20:0+blood cAMP signaling pathway 0 0 0.641538462 yes yes serum_fattyacid kegg 0.000278 NA dn no up no up up 20:0+blood Carbon metabolism 0 0 -0.58 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Cardiac muscle contraction 0.524561404 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no up 20:0+blood Central carbon metabolism in cancer -0.489473684 0 -0.413076923 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Chagas disease 0.480701754 0 0.457692308 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Chronic myeloid leukemia 0 0 0.622307692 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Cocaine addiction 0 0 0.617692308 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Colorectal cancer 0 0.55 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Cortisol synthesis and secretion 0 0 0.595384615 yes serum_fattyacid kegg 0.000278 NA dn no up no no up 20:0+blood Cushing syndrome 0 0 0.461538462 yes serum_fattyacid kegg 0.000278 NA dn no up no no up 20:0+blood Cytosolic DNA-sensing pathway 0.633333333 0 0.463846154 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Diabetic cardiomyopathy 0.524561404 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Endocrine and other factor-regulated calcium reabsorption 0 0 0.444615385 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Endocrine resistance 0 0 0.402307692 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Focal adhesion 0 0 -0.429230769 yes serum_fattyacid kegg 0.000278 NA dn no up no up up 20:0+blood Gastric cancer 0 0.561764706 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Glycolysis / Gluconeogenesis 0 0 -0.786153846 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood "Growth hormone synthesis, secretion and action" 0 0 0.419230769 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Hematopoietic cell lineage 0 0 -0.556153846 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Hepatitis C 0 0 0.420769231 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Huntington disease 0.531578947 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Inflammatory bowel disease 0 0 -0.43 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Insulin resistance 0 0 0.453846154 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Insulin secretion 0 0 0.623846154 yes yes serum_fattyacid kegg 0.000278 NA dn no up no up up 20:0+blood Kaposi sarcoma-associated herpesvirus infection 0.575438596 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no dn 20:0+blood Lachnospira -0.603007519 0 0 yes butyrate-producing serum_fattyacid Genus 0.000278 0.279 dn no up no no no 20:0+blood Leishmaniasis 0 0 -0.469230769 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Long-term depression 0 0 0.443076923 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Longevity regulating pathway - multiple species -0.633333333 0 -0.566923077 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood MAPK signaling pathway 0 0 -0.43 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Mineral absorption 0 0 0.439230769 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Morphine addiction 0 0 0.520769231 yes serum_fattyacid kegg 0.000278 NA dn no up no up up 20:0+blood Neurotrophin signaling pathway 0 0 0.406153846 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood NF-kappa B signaling pathway 0 0 0.406923077 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Non-alcoholic fatty liver disease 0.475438596 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Olfactory transduction -0.5 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Oxidative phosphorylation 0.468421053 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Pancreatic secretion 0.456140351 0 0.453076923 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Parabacteroides 0 0.490196078 0.425029926 yes serum_fattyacid Genus 0.000278 4.19E-05 dn no up no up up 20:0+blood Parkinson disease 0.561403509 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Pathways in cancer 0 0.508823529 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Pathways of neurodegeneration - multiple diseases 0.58245614 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Peroxisome -0.654385965 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Phenylacetic acid+stool 0.681318681 0 0 yes serum_fattyacid stool_cometabolism 0.000278 0.785 dn no up no no no 20:0+blood Prevotella 0 0 0.551795687 yes acetate-producing serum_fattyacid Genus 0.000278 0.287 dn no up no no no 20:0+blood Primary immunodeficiency -0.58245614 0 -0.550769231 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Prion disease 0.542105263 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Prostate cancer 0 0 0.520769231 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Proteoglycans in cancer 0 0 -0.419230769 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Regulation of lipolysis in adipocytes 0 0 0.401538462 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Relaxin signaling pathway 0.524561404 0 0.599230769 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Rheumatoid arthritis 0 0 -0.54 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood RIG-I-like receptor signaling pathway 0 0 0.423076923 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Ruminococcus 0 -0.646229429 0 yes serum_fattyacid Genus 0.000278 0.0679 dn no up no no dn 20:0+blood Salmonella infection 0 0 -0.476923077 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Shigellosis 0.568421053 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Signaling pathways regulating pluripotency of stem cells 0 0.520588235 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Small cell lung cancer 0 0 0.613846154 yes serum_fattyacid kegg 0.000278 NA dn no up no no up 20:0+blood TCA+stool -0.718019936 0 0 yes serum_fattyacid stool_bileacids 0.000278 0.458 dn no up no no no 20:0+blood Th1 and Th2 cell differentiation 0.663157895 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Th17 cell differentiation 0.607017544 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Thermogenesis 0.473684211 0 0 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Thyroid hormone synthesis 0 0 0.446153846 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood TNF signaling pathway 0 0 0.52 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Toxoplasmosis 0 0 -0.454615385 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Transcriptional misregulation in cancer 0 0 0.414615385 yes serum_fattyacid kegg 0.000278 NA dn no up no no no 20:0+blood Tuberculosis 0 0 -0.429230769 yes serum_fattyacid kegg 0.000278 NA dn no up no no dn 20:1-LPA+blood 16:0/20:5-PG+blood 0 0 0.40991453 serum_phospholipids serum_phospholipids 0.0187 0.00656 dn dn no no up no 20:1-LPA+blood 16:0/22:6-PE+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.0187 0.000934 dn dn no up up no 20:1-LPA+blood 16:1/16:1-PC+blood 0 0 -0.43042735 serum_phospholipids serum_phospholipids 0.0187 0.0177 dn dn no no no up 20:1-LPA+blood 16:1/18:2-PG+blood 0.47518797 0 0 serum_phospholipids serum_phospholipids 0.0187 1.40E-08 dn dn no no up up 20:1-LPA+blood 16:1+blood 0 0 -0.532991453 yes serum_phospholipids serum_fattyacid 0.0187 0.0186 dn dn no no no dn 20:1-LPA+blood 18:0-LPA+blood 0 0.81372549 0 serum_phospholipids serum_phospholipids 0.0187 0.0725 dn dn no no dn no 20:1-LPA+blood 18:2-LPA+blood 0 0.590686275 0 serum_phospholipids serum_phospholipids 0.0187 0.00684 dn dn no dn no up 20:1-LPA+blood 18:2/16:0-PC+blood 0.482706767 0 0 serum_phospholipids serum_phospholipids 0.0187 8.67E-05 dn dn no no up up 20:1-LPA+blood 18:2n6c+blood 0 0 -0.477606838 serum_phospholipids serum_fattyacid 0.0187 0.15 dn dn no no no no 20:1-LPA+blood 18:3n3+blood 0.547368421 0 -0.411282051 serum_phospholipids serum_fattyacid 0.0187 0.291 dn dn no no no no 20:1-LPA+blood 4-hydroxybenzoic acid+stool 0.763736264 0 0 serum_phospholipids stool_cometabolism 0.0187 0.0536 dn dn no no dn no 20:1-LPA+blood Adrenergic signaling in cardiomyocytes 0 -0.529411765 0 serum_phospholipids kegg 0.0187 NA dn dn no no no up 20:1-LPA+blood Aldosterone synthesis and secretion 0 -0.6 0 serum_phospholipids kegg 0.0187 NA dn dn no no up up 20:1-LPA+blood Allograft rejection 0 0.508823529 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Amphetamine addiction 0 -0.514705882 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Apoptosis 0 0.517647059 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Autoimmune thyroid disease 0 0.508823529 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Bacteroides 0 -0.49754902 0 LPS-producing serum_phospholipids Genus 0.0187 0.000267 dn dn no dn dn up 20:1-LPA+blood Butyricimonas 0 -0.777140508 0 butyrate-producing serum_phospholipids Genus 0.0187 0.17 dn dn no no no no 20:1-LPA+blood Cell adhesion molecules 0 0.529411765 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Cell cycle 0 -0.585294118 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Chemical carcinogenesis - receptor activation 0 -0.585294118 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Clostridium 0 0 0.472386999 serum_phospholipids Genus 0.0187 0.925 dn dn no no no no 20:1-LPA+blood Collinsella 0 0 0.507790373 serum_phospholipids Genus 0.0187 0.128 dn dn no no no no 20:1-LPA+blood Cushing syndrome 0 -0.588235294 0 serum_phospholipids kegg 0.0187 NA dn dn no no no up 20:1-LPA+blood DCA+stool -0.565934066 0 0 serum_phospholipids stool_bileacids 0.0187 0.195 dn dn no no no no 20:1-LPA+blood Dopaminergic synapse 0 -0.629411765 0 serum_phospholipids kegg 0.0187 NA dn dn no no up no 20:1-LPA+blood Endocytosis 0 0.532352941 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Fc gamma R-mediated phagocytosis 0 0.617647059 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Gemmiger -0.592481203 0 0 butyrate-producing serum_phospholipids Genus 0.0187 0.595 dn dn no no no no 20:1-LPA+blood Glucagon signaling pathway 0 -0.526470588 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Graft-versus-host disease 0 0.508823529 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood HDCA+stool 0 0 -0.476691729 serum_phospholipids stool_bileacids 0.0187 0.176 dn dn no no no no 20:1-LPA+blood IL-17 signaling pathway 0 0.670588235 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Influenza A 0 0.755882353 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood L-Tyrosine+stool 0.571428571 0 0 serum_phospholipids stool_cometabolism 0.0187 0.44 dn dn no no no no 20:1-LPA+blood Lipid and atherosclerosis 0 0.667647059 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Lysosome 0 0.605882353 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Morphine addiction 0 -0.585294118 0 serum_phospholipids kegg 0.0187 NA dn dn no no up up 20:1-LPA+blood mRNA surveillance pathway 0 -0.585294118 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Necroptosis -0.459649123 0 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Neuroactive ligand-receptor interaction 0 0.620588235 0 serum_phospholipids kegg 0.0187 NA dn dn no up up up 20:1-LPA+blood Neutrophil extracellular trap formation 0 0.541176471 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood NF-kappa B signaling pathway 0 0 -0.423076923 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Olfactory transduction 0 0.5 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Oscillospira -0.648120301 0 0 LPS-producing serum_phospholipids Genus 0.0187 0.62 dn dn no no no no 20:1-LPA+blood Osteoclast differentiation 0 0.567647059 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Peroxisome 0 0.570588235 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Pertussis 0 0.620588235 0 serum_phospholipids kegg 0.0187 NA dn dn no no no dn 20:1-LPA+blood Phagosome 0 0.520588235 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Protein processing in endoplasmic reticulum 0 -0.620588235 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Ras signaling pathway 0 -0.682352941 0 yes serum_phospholipids kegg 0.0187 NA dn dn no no up up 20:1-LPA+blood Retrograde endocannabinoid signaling 0 -0.514705882 0 serum_phospholipids kegg 0.0187 NA dn dn no no no up 20:1-LPA+blood Rheumatoid arthritis 0 0.723529412 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood RNA degradation 0 -0.538235294 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Salmonella infection 0.489473684 0.576470588 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Spinocerebellar ataxia 0 -0.517647059 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Staphylococcus aureus infection 0 0.717647059 0 serum_phospholipids kegg 0.0187 NA dn dn no up no no 20:1-LPA+blood Systemic lupus erythematosus 0 0.588235294 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Th1 and Th2 cell differentiation 0 0.538235294 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Thyroid hormone synthesis 0 -0.602941176 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Toll-like receptor signaling pathway 0 0.523529412 0 yes serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Toxoplasmosis 0 0.682352941 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Tuberculosis 0 0.673529412 0 serum_phospholipids kegg 0.0187 NA dn dn no no no dn 20:1-LPA+blood Type I diabetes mellitus 0 0.508823529 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Viral myocarditis 0 0.511764706 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Wnt signaling pathway 0 -0.558823529 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPA+blood Yersinia infection 0.459649123 0.564705882 0 serum_phospholipids kegg 0.0187 NA dn dn no no no no 20:1-LPC+blood "12,13-EPOME+blood" 0 -0.534881132 0 serum_phospholipids serum_ARA 0.217 0.901 no no no no no no 20:1-LPC+blood 14:0/18:0-PC+blood 0 0 -0.445470085 serum_phospholipids serum_phospholipids 0.217 0.00289 no no no up up no 20:1-LPC+blood 14:0+blood -0.55037594 0 -0.483760684 yes serum_phospholipids serum_fattyacid 0.217 0.00572 no no no up no dn 20:1-LPC+blood 16:0/16:0-PI+blood 0 0 -0.472820513 serum_phospholipids serum_phospholipids 0.217 0.358 no no no no no no 20:1-LPC+blood 16:0/16:1-PC+blood 0 0 -0.483076923 serum_phospholipids serum_phospholipids 0.217 0.00283 no no no up up no 20:1-LPC+blood 16:0/16:1-PI+blood 0 0 -0.493333333 serum_phospholipids serum_phospholipids 0.217 0.262 no no no no no no 20:1-LPC+blood 16:0/18:0-PC+blood 0 0 0.63008547 serum_phospholipids serum_phospholipids 0.217 0.521 no no no no no no 20:1-LPC+blood 16:0/18:1-PE+blood 0 0 -0.635555556 serum_phospholipids serum_phospholipids 0.217 0.000107 no no no up up no 20:1-LPC+blood 16:0/18:2-PI+blood -0.497744361 -0.544117647 -0.428376068 serum_phospholipids serum_phospholipids 0.217 0.269 no no no no no no 20:1-LPC+blood 16:0/20:4-PE+blood 0 0 -0.505641026 serum_phospholipids serum_phospholipids 0.217 0.00139 no no no up up no 20:1-LPC+blood 16:0/20:4-PI+blood 0 0 -0.442735043 serum_phospholipids serum_phospholipids 0.217 0.558 no no no no no no 20:1-LPC+blood 16:0/22:0-PE+blood 0 0 0.591111111 serum_phospholipids serum_phospholipids 0.217 0.00839 no no no dn no up 20:1-LPC+blood 16:0/22:6-PE+blood 0 0 -0.507008547 serum_phospholipids serum_phospholipids 0.217 0.000934 no no no up up no 20:1-LPC+blood 16:1+blood 0 0 -0.637606838 yes serum_phospholipids serum_fattyacid 0.217 0.0186 no no no no no dn 20:1-LPC+blood 18:0-LPC+blood 0 0 0.527521368 serum_phospholipids serum_phospholipids 0.217 0.554 no no no no no no 20:1-LPC+blood 18:0/18:0-PC+blood 0 0 0.630769231 serum_phospholipids serum_phospholipids 0.217 0.426 no no no no no no 20:1-LPC+blood 18:0/18:0-PE+blood 0 -0.575980392 0 serum_phospholipids serum_phospholipids 0.217 0.00896 no no no up up no 20:1-LPC+blood 18:0/18:1-PC+blood 0 0 0.604102564 serum_phospholipids serum_phospholipids 0.217 0.393 no no no no no no 20:1-LPC+blood 18:0/18:1-PE+blood 0 -0.546568627 0 serum_phospholipids serum_phospholipids 0.217 0.00716 no no no up up no 20:1-LPC+blood 18:0/18:1-PG+blood 0 0 -0.567179487 serum_phospholipids serum_phospholipids 0.217 0.000842 no no no no up no 20:1-LPC+blood 18:0/20:2-PC+blood 0 0 0.74017094 serum_phospholipids serum_phospholipids 0.217 0.733 no no no no no no 20:1-LPC+blood 18:0/22:6-PI+blood -0.505263158 0 0 serum_phospholipids serum_phospholipids 0.217 0.425 no no no no no no 20:1-LPC+blood 18:1-LPC+blood 0.703759398 0.791666667 0.64034188 serum_phospholipids serum_phospholipids 0.217 0.179 no no no no no no 20:1-LPC+blood 18:1/16:0-PE+blood 0 0 -0.524102564 serum_phospholipids serum_phospholipids 0.217 0.000182 no no no up up no 20:1-LPC+blood 18:1/16:1-PE+blood 0 0 -0.657435897 serum_phospholipids serum_phospholipids 0.217 0.000184 no no no up up no 20:1-LPC+blood 18:1/18:0-PE+blood 0 0 -0.608205128 serum_phospholipids serum_phospholipids 0.217 1.39E-06 no no no up up no 20:1-LPC+blood 18:1/18:1-PE+blood 0 0 -0.522735043 serum_phospholipids serum_phospholipids 0.217 1.03E-05 no no no up up no 20:1-LPC+blood 18:1/18:1-PI+blood 0.533834586 0 0.466666667 serum_phospholipids serum_phospholipids 0.217 0.111 no no no dn no no 20:1-LPC+blood 18:1/20:3-PC+blood 0 0.580882353 0 serum_phospholipids serum_phospholipids 0.217 0.00872 no no no no up up 20:1-LPC+blood 18:1/20:4-PC+blood 0 0.50245098 0 serum_phospholipids serum_phospholipids 0.217 0.582 no no no no no no 20:1-LPC+blood 18:2-LPC+blood 0 0 0.498803419 serum_phospholipids serum_phospholipids 0.217 0.00743 no no no dn no up 20:1-LPC+blood 18:2/18:1-PC+blood 0.551879699 0 0.403760684 serum_phospholipids serum_phospholipids 0.217 2.30E-05 no no no dn up up 20:1-LPC+blood 18:2/18:2-PC+blood 0.556390977 0 0 serum_phospholipids serum_phospholipids 0.217 1.98E-05 no no no dn up up 20:1-LPC+blood 18:3/16:0-PE+blood 0 0 -0.608205128 serum_phospholipids serum_phospholipids 0.217 0.00149 no no no up up no 20:1-LPC+blood 20:0-LPC+blood 0.452631579 0.742647059 0.522051282 serum_phospholipids serum_phospholipids 0.217 0.199 no no no no no no 20:1-LPC+blood 20:0+blood 0.717293233 0.62254902 0 yes serum_phospholipids serum_fattyacid 0.217 0.000278 no no no dn no up 20:1-LPC+blood 20:1-LPA+blood 0 0 0.411282051 serum_phospholipids serum_phospholipids 0.217 0.0187 no no no dn dn no 20:1-LPC+blood 20:1+blood 0.566917293 0.553921569 0.492649573 yes serum_phospholipids serum_fattyacid 0.217 2.56E-05 no no no dn dn dn 20:1-LPE+blood "12,13-EPOME+blood" 0 -0.502312258 0 serum_phospholipids serum_ARA 0.465 0.901 no no no no no no 20:1-LPE+blood 16:0/20:4-PC+blood 0 0.514705882 0 serum_phospholipids serum_phospholipids 0.465 0.0262 no no no no up no 20:1-LPE+blood 16:0/20:5-PC+blood 0 0 -0.420854701 serum_phospholipids serum_phospholipids 0.465 0.628 no no no no no no 20:1-LPE+blood 18:0/18:0-PE+blood 0 -0.585784314 0 serum_phospholipids serum_phospholipids 0.465 0.00896 no no no up up no 20:1-LPE+blood 18:0/18:1-PE+blood 0 -0.531862745 0 serum_phospholipids serum_phospholipids 0.465 0.00716 no no no up up no 20:1-LPE+blood 18:0/20:4-PC+blood 0 0.536764706 0 serum_phospholipids serum_phospholipids 0.465 0.454 no no no no no no 20:1-LPE+blood 18:1-LPC+blood 0.569924812 0 0 serum_phospholipids serum_phospholipids 0.465 0.179 no no no no no no 20:1-LPE+blood 18:1-LPE+blood 0.535338346 0 0.56991453 serum_phospholipids serum_phospholipids 0.465 0.117 no no no no no no 20:1-LPE+blood 18:1/18:1-PI+blood 0 0 0.537777778 serum_phospholipids serum_phospholipids 0.465 0.111 no no no dn no no 20:1-LPE+blood 18:2-LPA+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.465 0.00684 no no no dn no up 20:1-LPE+blood 18:2-LPC+blood 0 0 0.444786325 serum_phospholipids serum_phospholipids 0.465 0.00743 no no no dn no up 20:1-LPE+blood 18:2/18:1-PC+blood 0 0 0.532307692 serum_phospholipids serum_phospholipids 0.465 2.30E-05 no no no dn up up 20:1-LPE+blood 18:2/18:2-PC+blood 0 0 0.522735043 serum_phospholipids serum_phospholipids 0.465 1.98E-05 no no no dn up up 20:1-LPE+blood 18:2/20:4-PC+blood 0 0 0.502905983 serum_phospholipids serum_phospholipids 0.465 0.0145 no no no no no up 20:1-LPE+blood 18:3/18:2-PC+blood 0 0 0.455042735 serum_phospholipids serum_phospholipids 0.465 0.0394 no no no no no up 20:1-LPE+blood 20:0-LPC+blood 0 0.593137255 0.424273504 serum_phospholipids serum_phospholipids 0.465 0.199 no no no no no no 20:1-LPE+blood 20:0+blood 0.630075188 0.740196078 0 yes serum_phospholipids serum_fattyacid 0.465 0.000278 no no no dn no up 20:1-LPE+blood 20:1-LPC+blood 0.661654135 0.632352941 0.405811966 serum_phospholipids serum_phospholipids 0.465 0.217 no no no no no no 20:1/20:4-PC+blood 14:0-LPC+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.0419 0.00689 no no up up up no 20:1/20:4-PC+blood 14:1/18:2-PG+blood 0.466165414 0 0 serum_phospholipids serum_phospholipids 0.0419 0.00259 no no up no up up 20:1/20:4-PC+blood 16:0/14:0-PC+blood 0 0 0.547350427 serum_phospholipids serum_phospholipids 0.0419 0.0206 no no up no up up 20:1/20:4-PC+blood 16:0/16:0-PC+blood 0.458646617 0 0.446153846 serum_phospholipids serum_phospholipids 0.0419 0.00079 no no up no up up 20:1/20:4-PC+blood 16:0/18:1-PC+blood 0 0.580882353 0 serum_phospholipids serum_phospholipids 0.0419 6.15E-07 no no up up up up 20:1/20:4-PC+blood 16:0/18:2-PC+blood 0.49924812 0 0.650598291 serum_phospholipids serum_phospholipids 0.0419 3.24E-06 no no up no up up 20:1/20:4-PC+blood 16:0/20:3-PC+blood 0.472180451 0 0 serum_phospholipids serum_phospholipids 0.0419 5.43E-06 no no up no up up 20:1/20:4-PC+blood 16:0/22:0-PE+blood 0.735338346 0.639705882 0.604786325 serum_phospholipids serum_phospholipids 0.0419 0.00839 no no up dn no up 20:1/20:4-PC+blood 16:0/22:6-PC+blood 0.810526316 0.710784314 0.852307692 serum_phospholipids serum_phospholipids 0.0419 4.53E-05 no no up no up up 20:1/20:4-PC+blood 16:1/16:0-PC+blood 0.505263158 0.828431373 0.625299145 serum_phospholipids serum_phospholipids 0.0419 0.0215 no no up no up up 20:1/20:4-PC+blood 18:0/16:0-PC+blood 0 0.56372549 0 serum_phospholipids serum_phospholipids 0.0419 9.64E-07 no no up up up up 20:1/20:4-PC+blood 18:0/18:0-PC+blood 0 0.492647059 0 serum_phospholipids serum_phospholipids 0.0419 0.426 no no up no no no 20:1/20:4-PC+blood 18:0/18:1-PG+blood 0 0 -0.403076923 serum_phospholipids serum_phospholipids 0.0419 0.000842 no no up no up no 20:1/20:4-PC+blood 18:0/18:2-PC+blood 0.563909774 0 0.667692308 serum_phospholipids serum_phospholipids 0.0419 1.74E-06 no no up no up up 20:1/20:4-PC+blood 18:0/20:4-PC+blood 0 0.549019608 0.509059829 serum_phospholipids serum_phospholipids 0.0419 0.454 no no up no no no 20:1/20:4-PC+blood 18:0/20:5-PC+blood 0.496240602 0.482843137 0.562393162 serum_phospholipids serum_phospholipids 0.0419 0.17 no no up no no no 20:1/20:4-PC+blood 18:0/22:6-PC+blood 0.969924812 0.906862745 0.942564103 serum_phospholipids serum_phospholipids 0.0419 0.0775 no no up no no up 20:1/20:4-PC+blood 18:0/22:6-PI+blood 0.493233083 0.754901961 0 serum_phospholipids serum_phospholipids 0.0419 0.425 no no up no no no 20:1/20:4-PC+blood 18:1-LPE+blood -0.556390977 0 0 serum_phospholipids serum_phospholipids 0.0419 0.117 no no up no no no 20:1/20:4-PC+blood 18:1/16:0-PC+blood 0.502255639 0 0.642393162 serum_phospholipids serum_phospholipids 0.0419 2.43E-05 no no up no up up 20:1/20:4-PC+blood 18:1/16:0-PE+blood -0.557894737 0 0 serum_phospholipids serum_phospholipids 0.0419 0.000182 no no up up up no 20:1/20:4-PC+blood 18:1/18:0-PC+blood 0.577443609 0 0.655384615 serum_phospholipids serum_phospholipids 0.0419 1.83E-06 no no up no up up 20:1/20:4-PC+blood 18:1/18:2-PE+blood 0 0 -0.414700855 serum_phospholipids serum_phospholipids 0.0419 0.000293 no no up up up no 20:1/20:4-PC+blood 18:1/20:4-PC+blood 0 0.580882353 0.496068376 serum_phospholipids serum_phospholipids 0.0419 0.582 no no up no no no 20:1/20:4-PC+blood 18:1/22:6-PE+blood 0 0.590686275 0.476923077 serum_phospholipids serum_phospholipids 0.0419 0.0047 no no up no up no 20:1/20:4-PC+blood 18:2-LPC+blood 0 -0.531862745 0 serum_phospholipids serum_phospholipids 0.0419 0.00743 no no up dn no up 20:1/20:4-PC+blood 18:2/16:0-PC+blood 0 0 0.458461538 serum_phospholipids serum_phospholipids 0.0419 8.67E-05 no no up no up up 20:1/20:4-PC+blood 18:2/18:1-PC+blood 0 -0.661764706 0 serum_phospholipids serum_phospholipids 0.0419 2.30E-05 no no up dn up up 20:1/20:4-PC+blood 18:2/18:2-PC+blood 0 -0.671568627 0 serum_phospholipids serum_phospholipids 0.0419 1.98E-05 no no up dn up up 20:1/20:4-PC+blood 18:2/20:4-PC+blood 0.457142857 0 0 serum_phospholipids serum_phospholipids 0.0419 0.0145 no no up no no up 20:1/20:4-PC+blood 18:3/16:0-PE+blood 0 -0.519607843 0 serum_phospholipids serum_phospholipids 0.0419 0.00149 no no up up up no 20:1/20:4-PC+blood 20:0/20:4-PE+blood -0.57593985 -0.534313725 -0.406495726 serum_phospholipids serum_phospholipids 0.0419 0.00128 no no up up up no 20:1/20:4-PC+blood 20:0/20:5-PC+blood 0 0.693627451 0.611623932 serum_phospholipids serum_phospholipids 0.0419 0.882 no no up no no no 20:1/20:4-PE+blood 13-HODE+blood 0 -0.495098039 0 serum_phospholipids serum_ARA 0.0042 0.32 up up no no no no 20:1/20:4-PE+blood 14:0-LPC+blood -0.476691729 0 0 serum_phospholipids serum_phospholipids 0.0042 0.00689 up up no up up no 20:1/20:4-PE+blood 14:1/18:2-PG+blood -0.473684211 0 0.40034188 serum_phospholipids serum_phospholipids 0.0042 0.00259 up up no no up up 20:1/20:4-PE+blood 16:0/18:0-PS+blood 0.554887218 0.514705882 0.467350427 serum_phospholipids serum_phospholipids 0.0042 0.377 up up no no no no 20:1/20:4-PE+blood 16:0/18:1-PE+blood 0 0 0.552820513 serum_phospholipids serum_phospholipids 0.0042 0.000107 up up no up up no 20:1/20:4-PE+blood 16:0/20:4-PE+blood 0 0.514705882 0.593846154 serum_phospholipids serum_phospholipids 0.0042 0.00139 up up no up up no 20:1/20:4-PE+blood 16:0/20:4-PI+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 0.0042 0.558 up up no no no no 20:1/20:4-PE+blood 16:0/20:5-PG+blood 0.634586466 0 0 serum_phospholipids serum_phospholipids 0.0042 0.00656 up up no no up no 20:1/20:4-PE+blood 16:0/22:6-PE+blood 0.587969925 0.593137255 0.633504274 serum_phospholipids serum_phospholipids 0.0042 0.000934 up up no up up no 20:1/20:4-PE+blood 16:1+blood 0 0.566176471 0 yes serum_phospholipids serum_fattyacid 0.0042 0.0186 up up no no no dn 20:1/20:4-PE+blood 18:0-LPE+blood 0 0 0.48034188 serum_phospholipids serum_phospholipids 0.0042 0.491 up up no no no no 20:1/20:4-PE+blood 18:0/18:0-PE+blood 0 0 0.524102564 serum_phospholipids serum_phospholipids 0.0042 0.00896 up up no up up no 20:1/20:4-PE+blood 18:0/18:0-PS+blood 0.518796992 0.598039216 0.441367521 serum_phospholipids serum_phospholipids 0.0042 0.00617 up up no no up no 20:1/20:4-PE+blood 18:0/18:1-PE+blood 0 0.588235294 0.504957265 serum_phospholipids serum_phospholipids 0.0042 0.00716 up up no up up no 20:1/20:4-PE+blood 18:0/18:1-PG+blood 0 0.737745098 0.579487179 serum_phospholipids serum_phospholipids 0.0042 0.000842 up up no no up no 20:1/20:4-PE+blood 18:0/18:2-PI+blood 0.502255639 0 0 serum_phospholipids serum_phospholipids 0.0042 0.179 up up no no no no 20:1/20:4-PE+blood 18:0/20:4-PI+blood 0.648120301 0 0.455726496 serum_phospholipids serum_phospholipids 0.0042 0.167 up up no no no no 20:1/20:4-PE+blood 18:0/22:6-PE+blood 0 0.595588235 0.528205128 serum_phospholipids serum_phospholipids 0.0042 0.00022 up up no up up no 20:1/20:4-PE+blood 18:1/16:0-PE+blood 0 0.524509804 0.732649573 serum_phospholipids serum_phospholipids 0.0042 0.000182 up up no up up no 20:1/20:4-PE+blood 18:1/16:1-PE+blood 0 0 0.56991453 serum_phospholipids serum_phospholipids 0.0042 0.000184 up up no up up no 20:1/20:4-PE+blood 18:1/18:0-PE+blood 0 0.573529412 0.682735043 serum_phospholipids serum_phospholipids 0.0042 1.39E-06 up up no up up no 20:1/20:4-PE+blood 18:1/18:0-PS+blood 0.481203008 0 0 serum_phospholipids serum_phospholipids 0.0042 0.193 up up no no no no 20:1/20:4-PE+blood 18:1/18:1-PE+blood 0.454135338 0.615196078 0.66974359 serum_phospholipids serum_phospholipids 0.0042 1.03E-05 up up no up up no 20:1/20:4-PE+blood 18:1/18:2-PE+blood 0 0 0.469401709 serum_phospholipids serum_phospholipids 0.0042 0.000293 up up no up up no 20:1/20:4-PE+blood 18:1/20:4-PE+blood 0.792481203 0.808823529 0.780512821 serum_phospholipids serum_phospholipids 0.0042 0.0578 up up no up no no 20:1/20:4-PE+blood 18:1/22:6-PE+blood 0.596992481 0 0 serum_phospholipids serum_phospholipids 0.0042 0.0047 up up no no up no 20:1/20:4-PE+blood 18:2-LPA+blood 0 0 -0.42974359 serum_phospholipids serum_phospholipids 0.0042 0.00684 up up no dn no up 20:1/20:4-PE+blood 18:2-LPC+blood 0 0 -0.509059829 serum_phospholipids serum_phospholipids 0.0042 0.00743 up up no dn no up 20:1/20:4-PE+blood 18:2-LPE+blood -0.446616541 0 0 serum_phospholipids serum_phospholipids 0.0042 0.112 up up no no no no 20:1/20:4-PE+blood 18:3/16:0-PE+blood 0 0.529411765 0.539145299 serum_phospholipids serum_phospholipids 0.0042 0.00149 up up no up up no 20:1/20:4-PE+blood 18:3n6+blood 0 0.485294118 0 serum_phospholipids serum_fattyacid 0.0042 0.0463 up up no up no dn 20:1/20:4-PE+blood 20:0/20:4-PE+blood 0.727819549 0.68627451 0.856410256 serum_phospholipids serum_phospholipids 0.0042 0.00128 up up no up up no 20:1/20:4-PE+blood 20:0/20:5-PC+blood 0.633082707 0 0 serum_phospholipids serum_phospholipids 0.0042 0.882 up up no no no no 20:1/20:4-PE+blood 20:1-LPC+blood 0 0 -0.419487179 serum_phospholipids serum_phospholipids 0.0042 0.217 up up no no no no 20:1+blood 14:0/16:0-PC+blood -0.460150376 0 0 yes serum_fattyacid serum_phospholipids 2.56E-05 0.0358 dn dn dn no up no 20:1+blood 15-HETE+blood 0.446982524 -0.537618109 -0.559892923 yes serum_fattyacid serum_ARA 2.56E-05 0.819 dn dn dn no no no 20:1+blood 16:0/16:0-PI+blood -0.545864662 0 0 yes serum_fattyacid serum_phospholipids 2.56E-05 0.358 dn dn dn no no no 20:1+blood 16:0/16:1-PI+blood -0.454135338 0 0 yes serum_fattyacid serum_phospholipids 2.56E-05 0.262 dn dn dn no no no 20:1+blood 16:0/18:1-PE+blood 0 0 -0.461196581 yes serum_fattyacid serum_phospholipids 2.56E-05 0.000107 dn dn dn up up no 20:1+blood 16:0/18:2-PI+blood -0.518796992 -0.553921569 0 yes serum_fattyacid serum_phospholipids 2.56E-05 0.269 dn dn dn no no no 20:1+blood 16:0/18:3-PC+blood 0 -0.490196078 0 yes serum_fattyacid serum_phospholipids 2.56E-05 0.00216 dn dn dn no up up 20:1+blood 16:0/20:5-PC+blood 0 0 -0.498119658 yes serum_fattyacid serum_phospholipids 2.56E-05 0.628 dn dn dn no no no 20:1+blood 16:0/22:6-PE+blood 0 0 -0.496068376 yes serum_fattyacid serum_phospholipids 2.56E-05 0.000934 dn dn dn up up no 20:1+blood 18:0-LPC+blood 0 0 0.416068376 yes serum_fattyacid serum_phospholipids 2.56E-05 0.554 dn dn dn no no no 20:1+blood 18:0/18:0-PC+blood 0 0 0.473504274 yes serum_fattyacid serum_phospholipids 2.56E-05 0.426 dn dn dn no no no 20:1+blood 18:0/18:1-PC+blood 0 0 0.494700855 yes serum_fattyacid serum_phospholipids 2.56E-05 0.393 dn dn dn no no no 20:1+blood 18:0/18:1-PI+blood 0 0 0.602051282 yes serum_fattyacid serum_phospholipids 2.56E-05 0.599 dn dn dn no no no 20:1+blood 18:0/20:2-PC+blood 0 0 0.487179487 yes serum_fattyacid serum_phospholipids 2.56E-05 0.733 dn dn dn no no no 20:1+blood 18:0/22:6-PA+blood -0.469172932 0 0 yes serum_fattyacid serum_phospholipids 2.56E-05 0.22 dn dn dn no no no 20:1+blood 18:0/22:6-PE+blood 0 0 -0.491965812 yes serum_fattyacid serum_phospholipids 2.56E-05 0.00022 dn dn dn up up no 20:1+blood 18:0/22:6-PI+blood -0.67518797 0 0 yes serum_fattyacid serum_phospholipids 2.56E-05 0.425 dn dn dn no no no 20:1+blood 18:1-LPC+blood 0.487218045 0.634803922 0 yes serum_fattyacid serum_phospholipids 2.56E-05 0.179 dn dn dn no no no 20:1+blood 18:1/16:0-PI+blood 0 0 0.446837607 yes serum_fattyacid serum_phospholipids 2.56E-05 0.793 dn dn dn no no no 20:1+blood 18:1/16:1-PE+blood 0 0 -0.403760684 yes serum_fattyacid serum_phospholipids 2.56E-05 0.000184 dn dn dn up up no 20:1+blood 18:1/18:1-PI+blood 0 0 0.599316239 yes serum_fattyacid serum_phospholipids 2.56E-05 0.111 dn dn dn dn no no 20:1+blood 18:1/20:4-PE+blood 0 0 -0.40034188 yes serum_fattyacid serum_phospholipids 2.56E-05 0.0578 dn dn dn up no no 20:1+blood 18:1/22:6-PE+blood 0 0 -0.401025641 yes serum_fattyacid serum_phospholipids 2.56E-05 0.0047 dn dn dn no up no 20:1+blood 18:1+blood 0 0.556372549 0 yes yes serum_fattyacid serum_fattyacid 2.56E-05 0.00202 dn dn dn up no dn 20:1+blood 18:2/18:1-PC+blood 0.458646617 0 0 yes serum_fattyacid serum_phospholipids 2.56E-05 2.30E-05 dn dn dn dn up up 20:1+blood 18:2/18:2-PC+blood 0.467669173 0 0 yes serum_fattyacid serum_phospholipids 2.56E-05 1.98E-05 dn dn dn dn up up 20:1+blood 2-methyl-butyric acid m-C4+blood 0.485714286 0 0 yes serum_fattyacid serum_scfa 2.56E-05 0.262 dn dn dn no no no 20:1+blood 20:0-LPC+blood 0 0 0.493333333 yes serum_fattyacid serum_phospholipids 2.56E-05 0.199 dn dn dn no no no 20:1+blood 20:0+blood 0.684210526 0 0 yes yes serum_fattyacid serum_fattyacid 2.56E-05 0.000278 dn dn dn dn no up 20:1+blood Acetic acid+stool 0 0.727272727 0 yes yes serum_fattyacid stool_scfa 2.56E-05 0.0656 dn dn dn dn no no 20:1+blood Adipocytokine signaling pathway 0.557894737 0 0 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no no no 20:1+blood Amoebiasis 0 0 -0.408461538 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no no no 20:1+blood Anaerostipes -0.4488018 0 0 yes butyrate-producing serum_fattyacid Genus 2.56E-05 0.568 dn dn dn no no no 20:1+blood Central carbon metabolism in cancer -0.463157895 0 0 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no no no 20:1+blood Cytosolic DNA-sensing pathway 0.521052632 0 0 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no no no 20:1+blood Dorea 0 -0.490196078 0 yes serum_fattyacid Genus 2.56E-05 0.00362 dn dn dn up no dn 20:1+blood GABAergic synapse 0 0 -0.49 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no up up 20:1+blood Glutamatergic synapse 0 0 -0.448461538 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no up up 20:1+blood Insulin resistance 0 0 0.417692308 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no no no 20:1+blood Insulin signaling pathway -0.457894737 0 0 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no no no 20:1+blood Longevity regulating pathway - multiple species -0.480701754 0 0 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no no no 20:1+blood Oocyte meiosis -0.478947368 0 0 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no no no 20:1+blood Oxytocin signaling pathway 0 0 -0.423846154 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no no no 20:1+blood Phenylacetic acid+stool 0.813186813 0 0 yes serum_fattyacid stool_cometabolism 2.56E-05 0.785 dn dn dn no no no 20:1+blood Primary immunodeficiency -0.536842105 0 0 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no no no 20:1+blood Roseburia 0 0 -0.417435897 yes butyrate-producing serum_fattyacid Genus 2.56E-05 0.495 dn dn dn no no no 20:1+blood Ruminococcus 0 -0.605763449 0 yes serum_fattyacid Genus 2.56E-05 0.0679 dn dn dn no no dn 20:1+blood Salivary secretion 0 0 -0.426923077 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no no no 20:1+blood Th1 and Th2 cell differentiation 0.563157895 0 0.608461538 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no no no 20:1+blood Th17 cell differentiation 0 0 0.554615385 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no no no 20:1+blood Tight junction 0 0 -0.411538462 yes serum_fattyacid kegg 2.56E-05 NA dn dn dn no no no 20:1+blood total_stool_scfa+stool 0 0.681818182 0 yes serum_fattyacid stool_scfa 2.56E-05 0.0534 dn dn dn dn no up 20:2-LPC+blood "12,13-EPOME+blood" 0 0 -0.413651647 serum_phospholipids serum_ARA 0.119 0.901 no no up no no no 20:2-LPC+blood 13-HODE+blood 0.57593985 0 0 serum_phospholipids serum_ARA 0.119 0.32 no no up no no no 20:2-LPC+blood 16:0-LPC+blood 0.512781955 -0.514705882 0 serum_phospholipids serum_phospholipids 0.119 0.00456 no no up up up no 20:2-LPC+blood 16:0-LPE+blood -0.557894737 0 0 serum_phospholipids serum_phospholipids 0.119 0.0711 no no up up up no 20:2-LPC+blood 16:0/14:0-PC+blood 0 0.49754902 0.610940171 serum_phospholipids serum_phospholipids 0.119 0.0206 no no up no up up 20:2-LPC+blood 16:0/16:0-PC+blood 0 0 0.431794872 serum_phospholipids serum_phospholipids 0.119 0.00079 no no up no up up 20:2-LPC+blood 16:0/18:0-PC+blood 0 0 0.594529915 serum_phospholipids serum_phospholipids 0.119 0.521 no no up no no no 20:2-LPC+blood 16:0/18:0-PS+blood 0 0 -0.604102564 serum_phospholipids serum_phospholipids 0.119 0.377 no no up no no no 20:2-LPC+blood 16:0/18:1-PE+blood 0 0 -0.44957265 serum_phospholipids serum_phospholipids 0.119 0.000107 no no up up up no 20:2-LPC+blood 16:0/20:3-PC+blood 0.612030075 0.509803922 0.587692308 serum_phospholipids serum_phospholipids 0.119 5.43E-06 no no up no up up 20:2-LPC+blood 16:0/20:4-PE+blood 0 0 -0.469401709 serum_phospholipids serum_phospholipids 0.119 0.00139 no no up up up no 20:2-LPC+blood 16:0/20:5-PC+blood -0.679699248 0 0 serum_phospholipids serum_phospholipids 0.119 0.628 no no up no no no 20:2-LPC+blood 16:0/22:6-PE+blood 0 0 -0.460512821 serum_phospholipids serum_phospholipids 0.119 0.000934 no no up up up no 20:2-LPC+blood 16:1/18:2-PG+blood 0.571428571 0 0 serum_phospholipids serum_phospholipids 0.119 1.40E-08 no no up no up up 20:2-LPC+blood 18:0-LPC+blood 0 0 0.45025641 serum_phospholipids serum_phospholipids 0.119 0.554 no no up no no no 20:2-LPC+blood 18:0/18:0-PC+blood 0 0 0.417435897 serum_phospholipids serum_phospholipids 0.119 0.426 no no up no no no 20:2-LPC+blood 18:0/18:0-PE+blood -0.511278195 -0.482843137 0 serum_phospholipids serum_phospholipids 0.119 0.00896 no no up up up no 20:2-LPC+blood 18:0/18:0-PS+blood 0 0 -0.608205128 serum_phospholipids serum_phospholipids 0.119 0.00617 no no up no up no 20:2-LPC+blood 18:0/18:1-PC+blood 0 0 0.404444444 serum_phospholipids serum_phospholipids 0.119 0.393 no no up no no no 20:2-LPC+blood 18:0/18:1-PE+blood -0.485714286 0 0 serum_phospholipids serum_phospholipids 0.119 0.00716 no no up up up no 20:2-LPC+blood 18:0/18:1-PG+blood 0 0 -0.617777778 serum_phospholipids serum_phospholipids 0.119 0.000842 no no up no up no 20:2-LPC+blood 18:0/18:2-PC+blood 0 0 0.634188034 serum_phospholipids serum_phospholipids 0.119 1.74E-06 no no up no up up 20:2-LPC+blood 18:0/20:2-PC+blood 0 0 0.552820513 serum_phospholipids serum_phospholipids 0.119 0.733 no no up no no no 20:2-LPC+blood 18:0/20:3-PC+blood 0 0 0.509059829 serum_phospholipids serum_phospholipids 0.119 0.0682 no no up no up no 20:2-LPC+blood 18:0/20:3-PI+blood 0.678195489 0 0 serum_phospholipids serum_phospholipids 0.119 0.377 no no up no no no 20:2-LPC+blood 18:0/20:5-PC+blood 0 0 0.408547009 serum_phospholipids serum_phospholipids 0.119 0.17 no no up no no no 20:2-LPC+blood 18:1-LPC+blood 0.645112782 0 0 serum_phospholipids serum_phospholipids 0.119 0.179 no no up no no no 20:2-LPC+blood 18:1/16:0-PE+blood 0 0 -0.457094017 serum_phospholipids serum_phospholipids 0.119 0.000182 no no up up up no 20:2-LPC+blood 18:1/16:1-PE+blood 0 0 -0.415384615 serum_phospholipids serum_phospholipids 0.119 0.000184 no no up up up no 20:2-LPC+blood 18:1/18:0-PC+blood 0 0 0.63965812 serum_phospholipids serum_phospholipids 0.119 1.83E-06 no no up no up up 20:2-LPC+blood 18:1/18:0-PE+blood 0 0 -0.495384615 serum_phospholipids serum_phospholipids 0.119 1.39E-06 no no up up up no 20:2-LPC+blood 18:1/18:1-PC+blood 0.657142857 0 0.55008547 serum_phospholipids serum_phospholipids 0.119 1.34E-05 no no up no up up 20:2-LPC+blood 18:1/18:1-PE+blood 0 0 -0.488547009 serum_phospholipids serum_phospholipids 0.119 1.03E-05 no no up up up no 20:2-LPC+blood 18:1/18:2-PE+blood 0 0 -0.478974359 serum_phospholipids serum_phospholipids 0.119 0.000293 no no up up up no 20:2-LPC+blood 18:1/18:2-PG+blood 0.544360902 0 0 serum_phospholipids serum_phospholipids 0.119 5.58E-07 no no up no up up 20:2-LPC+blood 18:1/18:2-PI+blood 0.479699248 0 0 serum_phospholipids serum_phospholipids 0.119 0.0164 no no up dn no up 20:2-LPC+blood 18:1/20:3-PC+blood 0.536842105 0.691176471 0.708717949 serum_phospholipids serum_phospholipids 0.119 0.00872 no no up no up up 20:2-LPC+blood 18:1/20:4-PE+blood 0 0 -0.418803419 serum_phospholipids serum_phospholipids 0.119 0.0578 no no up up no no 20:2-LPC+blood 18:2-LPA+blood 0.490225564 0 0 serum_phospholipids serum_phospholipids 0.119 0.00684 no no up dn no up 20:2-LPC+blood 18:2/16:0-PC+blood 0.482706767 0 0.508376068 serum_phospholipids serum_phospholipids 0.119 8.67E-05 no no up no up up 20:2-LPC+blood 18:2/18:1-PC+blood 0.603007519 0 0.558290598 serum_phospholipids serum_phospholipids 0.119 2.30E-05 no no up dn up up 20:2-LPC+blood 18:2/18:2-PC+blood 0.530827068 0 0.545982906 serum_phospholipids serum_phospholipids 0.119 1.98E-05 no no up dn up up 20:2-LPC+blood 18:2/18:2-PS+blood 0 0 -0.416752137 serum_phospholipids serum_phospholipids 0.119 0.00674 no no up up up no 20:2-LPC+blood 18:2n6c+blood 0 0 0.427008547 serum_phospholipids serum_fattyacid 0.119 0.15 no no up no no no 20:2-LPC+blood 20:0-LPC+blood 0 0.612745098 0 serum_phospholipids serum_phospholipids 0.119 0.199 no no up no no no 20:2-LPC+blood 20:0-LPE+blood 0 0 0.405811966 serum_phospholipids serum_phospholipids 0.119 0.0615 no no up no no up 20:2-LPC+blood 20:0+blood 0 0.553921569 0 yes serum_phospholipids serum_fattyacid 0.119 0.000278 no no up dn no up 20:2-LPC+blood 20:1-LPC+blood 0 0.698529412 0.55965812 serum_phospholipids serum_phospholipids 0.119 0.217 no no up no no no 20:2-LPC+blood 20:1-LPE+blood 0 0.710784314 0 serum_phospholipids serum_phospholipids 0.119 0.465 no no up no no no 20:2-LPC+blood 20:2+blood 0.726315789 0 0.633504274 serum_phospholipids serum_fattyacid 0.119 0.478 no no up no no no 20:2-LPE+blood 13-HODE+blood 0 0.50245098 0 serum_phospholipids serum_ARA 0.177 0.32 no no no no no no 20:2-LPE+blood 16:0/18:0-PC+blood 0 0 0.431794872 serum_phospholipids serum_phospholipids 0.177 0.521 no no no no no no 20:2-LPE+blood 18:0/18:2-PC+blood 0 0 0.433162393 serum_phospholipids serum_phospholipids 0.177 1.74E-06 no no no no up up 20:2-LPE+blood 18:1/18:0-PC+blood 0 0 0.457094017 serum_phospholipids serum_phospholipids 0.177 1.83E-06 no no no no up up 20:2-LPE+blood 18:2/18:1-PC+blood 0 0 0.596581197 serum_phospholipids serum_phospholipids 0.177 2.30E-05 no no no dn up up 20:2-LPE+blood 18:2/18:2-PC+blood 0 0 0.616410256 serum_phospholipids serum_phospholipids 0.177 1.98E-05 no no no dn up up 20:2-LPE+blood 18:2/20:4-PC+blood 0 0 0.423589744 serum_phospholipids serum_phospholipids 0.177 0.0145 no no no no no up 20:2-LPE+blood 18:3/18:2-PC+blood 0 0 0.427008547 serum_phospholipids serum_phospholipids 0.177 0.0394 no no no no no up 20:2-LPE+blood 20:0+blood 0.485714286 0.580882353 0 yes serum_phospholipids serum_fattyacid 0.177 0.000278 no no no dn no up 20:2-LPE+blood 20:1-LPC+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.177 0.217 no no no no no no 20:2-LPE+blood 20:1-LPE+blood 0.566917293 0.742647059 0.582905983 serum_phospholipids serum_phospholipids 0.177 0.465 no no no no no no 20:2-LPE+blood 20:2-LPC+blood 0 0.737745098 0.526153846 serum_phospholipids serum_phospholipids 0.177 0.119 no no no no no up 20:2/18:0-PC+blood "12,13-EPOME+blood" 0 0 -0.481943192 serum_phospholipids serum_ARA 0.0427 0.901 no up no no no no 20:2/18:0-PC+blood 14:0-LPC+blood 0.467669173 0 0 serum_phospholipids serum_phospholipids 0.0427 0.00689 no up no up up no 20:2/18:0-PC+blood 14:0/16:0-PC+blood 0 0 0.464615385 serum_phospholipids serum_phospholipids 0.0427 0.0358 no up no no up no 20:2/18:0-PC+blood 14:0/18:0-PC+blood 0 0.693627451 0 serum_phospholipids serum_phospholipids 0.0427 0.00289 no up no up up no 20:2/18:0-PC+blood 14:0/18:2-PC+blood 0.690225564 0 0 serum_phospholipids serum_phospholipids 0.0427 0.102 no up no no up no 20:2/18:0-PC+blood 14:0/20:4-PC+blood 0.721804511 0 0 serum_phospholipids serum_phospholipids 0.0427 0.486 no up no no no no 20:2/18:0-PC+blood 16:0/16:1-PC+blood 0 0.715686275 0 serum_phospholipids serum_phospholipids 0.0427 0.00283 no up no up up no 20:2/18:0-PC+blood 16:0/16:1-PI+blood 0 0.779411765 0.412649573 serum_phospholipids serum_phospholipids 0.0427 0.262 no up no no no no 20:2/18:0-PC+blood 16:0/18:2-PI+blood 0 0.49754902 0 serum_phospholipids serum_phospholipids 0.0427 0.269 no up no no no no 20:2/18:0-PC+blood 16:0/20:3-PC+blood 0 0.578431373 0.722393162 serum_phospholipids serum_phospholipids 0.0427 5.43E-06 no up no no up up 20:2/18:0-PC+blood 16:0/20:4-PI+blood 0 0.549019608 0.416068376 serum_phospholipids serum_phospholipids 0.0427 0.558 no up no no no no 20:2/18:0-PC+blood 16:1/18:1-PG+blood 0 0.49754902 0 serum_phospholipids serum_phospholipids 0.0427 3.21E-05 no up no no up up 20:2/18:0-PC+blood 18:0/18:0-PC+blood 0 0.855392157 0.496752137 serum_phospholipids serum_phospholipids 0.0427 0.426 no up no no no no 20:2/18:0-PC+blood 18:0/18:1-PC+blood 0 0.860294118 0.47965812 serum_phospholipids serum_phospholipids 0.0427 0.393 no up no no no no 20:2/18:0-PC+blood 18:0/18:1-PI+blood 0 0.553921569 0 serum_phospholipids serum_phospholipids 0.0427 0.599 no up no no no no 20:2/18:0-PC+blood 18:0/20:2-PC+blood 0.536842105 0.843137255 0.45982906 serum_phospholipids serum_phospholipids 0.0427 0.733 no up no no no no 20:2/18:0-PC+blood 18:0/20:3-PC+blood 0.983458647 0.99754902 0.992478632 serum_phospholipids serum_phospholipids 0.0427 0.0682 no up no no up no 20:2/18:0-PC+blood 18:0/20:3-PI+blood 0 0.620098039 0 serum_phospholipids serum_phospholipids 0.0427 0.377 no up no no no no 20:2/18:0-PC+blood 18:0/20:5-PC+blood 0 -0.490196078 0 serum_phospholipids serum_phospholipids 0.0427 0.17 no up no no no no 20:2/18:0-PC+blood 18:0+blood 0.584962406 0 0 serum_phospholipids serum_fattyacid 0.0427 0.344 no up no no no no 20:2/18:0-PC+blood 18:1/18:1-PC+blood 0 0.632352941 0.708717949 serum_phospholipids serum_phospholipids 0.0427 1.34E-05 no up no no up up 20:2/18:0-PC+blood 18:1/18:1-PG+blood 0 0.715686275 0 serum_phospholipids serum_phospholipids 0.0427 0.00352 no up no no up up 20:2/18:0-PC+blood 18:1/20:3-PC+blood 0 0.558823529 0.706666667 serum_phospholipids serum_phospholipids 0.0427 0.00872 no up no no up up 20:2/18:0-PC+blood 18:2-LPC+blood 0 -0.632352941 0 serum_phospholipids serum_phospholipids 0.0427 0.00743 no up no dn no up 20:2/18:0-PC+blood 18:2/16:0-PC+blood 0 -0.551470588 0 serum_phospholipids serum_phospholipids 0.0427 8.67E-05 no up no no up up 20:2/18:0-PC+blood 18:3-LPC+blood 0 -0.705882353 0 serum_phospholipids serum_phospholipids 0.0427 0.147 no up no no no no 20:2/18:0-PC+blood 18:3n3+blood 0 -0.762254902 0 serum_phospholipids serum_fattyacid 0.0427 0.291 no up no no no no 20:2/18:0-PC+blood 18:3n6+blood 0.481203008 0 0 serum_phospholipids serum_fattyacid 0.0427 0.0463 no up no up no dn 20:2/18:0-PC+blood 20:0+blood 0 0 0.412649573 yes serum_phospholipids serum_fattyacid 0.0427 0.000278 no up no dn no up 20:2/18:0-PC+blood 20:2-LPC+blood 0 0 0.496068376 serum_phospholipids serum_phospholipids 0.0427 0.119 no up no no no up 20:2/18:0-PC+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0.642857143 0 0 serum_phospholipids stool_cometabolism 0.0427 0.33 no up no no no no 20:2/18:0-PC+blood Adipocytokine signaling pathway 0 0 0.550769231 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood AMPK signaling pathway 0 0 0.413846154 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Arachidonic acid metabolism 0 0 0.429230769 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Biosynthesis of cofactors 0 0 0.425384615 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Central carbon metabolism in cancer 0 0 -0.483846154 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Clostridium 0.500188076 0.562844986 0 serum_phospholipids Genus 0.0427 0.925 no up no no no no 20:2/18:0-PC+blood Colorectal cancer 0 0 -0.407692308 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Ferroptosis 0 0 0.55 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood FoxO signaling pathway 0 0 -0.633846154 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Gastric cancer 0 0 -0.406923077 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Glioma 0 0 -0.436923077 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Glutathione metabolism 0 0 0.520769231 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood "Glycine, serine and threonine metabolism" 0 0 0.462307692 serum_phospholipids kegg 0.0427 NA no up no no up no 20:2/18:0-PC+blood HDCA+stool 0 0 -0.490225564 serum_phospholipids stool_bileacids 0.0427 0.176 no up no no no no 20:2/18:0-PC+blood Kaposi sarcoma-associated herpesvirus infection 0 0 0.623846154 serum_phospholipids kegg 0.0427 NA no up no no no dn 20:2/18:0-PC+blood Longevity regulating pathway 0 0 0.446923077 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Malaria 0 0 0.401538462 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Mineral absorption 0 0 0.49 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Mitophagy - animal 0 0 0.441538462 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Necroptosis 0 0 0.426923077 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood NOD-like receptor signaling pathway 0 -0.523529412 0 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood nutriCA+stool 0 0.834897522 0 serum_phospholipids stool_bileacids 0.0427 0.481 no up no no no no 20:2/18:0-PC+blood Oocyte meiosis 0 0 -0.48 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Pathways of neurodegeneration - multiple diseases 0 0 0.467692308 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Phosphatidylinositol signaling system 0 0 -0.474615385 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Platinum drug resistance 0 0 -0.47 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Porphyrin and chlorophyll metabolism 0 0 0.493076923 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Primary immunodeficiency 0 0 -0.480769231 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Progesterone-mediated oocyte maturation 0 0 -0.504615385 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Purine metabolism 0 0 0.426923077 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Ruminococcus 0 0.615196078 0 acetate-producing serum_phospholipids Genus 0.0427 0.335 no up no no no no 20:2/18:0-PC+blood Shigellosis 0 0 0.476923077 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Sphingolipid signaling pathway 0 0 -0.515384615 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Spinocerebellar ataxia 0 0 -0.456153846 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Thyroid hormone synthesis 0 0 0.476923077 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:0-PC+blood Ubiquitin mediated proteolysis 0 0 0.421538462 serum_phospholipids kegg 0.0427 NA no up no no no no 20:2/18:1-PE+blood 11-HETE+blood 0 0.547766103 0 serum_phospholipids serum_ARA 0.00208 0.464 up up no no no no 20:2/18:1-PE+blood 14:0/16:0-PC+blood 0 0 0.417435897 serum_phospholipids serum_phospholipids 0.00208 0.0358 up up no no up no 20:2/18:1-PE+blood 14:0/18:0-PC+blood 0 0.644607843 0 serum_phospholipids serum_phospholipids 0.00208 0.00289 up up no up up no 20:2/18:1-PE+blood 16:0-LPE+blood 0 0 0.436581197 serum_phospholipids serum_phospholipids 0.00208 0.0711 up up no up up no 20:2/18:1-PE+blood 16:0/14:0-PC+blood -0.454135338 0 -0.48991453 serum_phospholipids serum_phospholipids 0.00208 0.0206 up up no no up up 20:2/18:1-PE+blood 16:0/16:0-PI+blood 0.473684211 0 0 serum_phospholipids serum_phospholipids 0.00208 0.358 up up no no no no 20:2/18:1-PE+blood 16:0/16:1-PC+blood 0 0.671568627 0.402393162 serum_phospholipids serum_phospholipids 0.00208 0.00283 up up no up up no 20:2/18:1-PE+blood 16:0/16:1-PI+blood 0 0.595588235 0.410598291 serum_phospholipids serum_phospholipids 0.00208 0.262 up up no no no no 20:2/18:1-PE+blood 16:0/18:0-PS+blood 0.777443609 0 0.481709402 serum_phospholipids serum_phospholipids 0.00208 0.377 up up no no no no 20:2/18:1-PE+blood 16:0/18:1-PC+blood -0.503759398 0 0 serum_phospholipids serum_phospholipids 0.00208 6.15E-07 up up no up up up 20:2/18:1-PE+blood 16:0/18:1-PE+blood 0.795488722 0.757352941 0.653333333 serum_phospholipids serum_phospholipids 0.00208 0.000107 up up no up up no 20:2/18:1-PE+blood 16:0/18:2-PC+blood -0.639097744 0 0 serum_phospholipids serum_phospholipids 0.00208 3.24E-06 up up no no up up 20:2/18:1-PE+blood 16:0/18:2-PI+blood 0 0.774509804 0 serum_phospholipids serum_phospholipids 0.00208 0.269 up up no no no no 20:2/18:1-PE+blood 16:0/20:4-PC+blood -0.562406015 -0.674019608 0 serum_phospholipids serum_phospholipids 0.00208 0.0262 up up no no up no 20:2/18:1-PE+blood 16:0/20:4-PE+blood 0.609022556 0.585784314 0.569230769 serum_phospholipids serum_phospholipids 0.00208 0.00139 up up no up up no 20:2/18:1-PE+blood 16:0/20:4-PI+blood 0 0.517156863 0.450940171 serum_phospholipids serum_phospholipids 0.00208 0.558 up up no no no no 20:2/18:1-PE+blood 16:0/22:6-PC+blood 0 -0.568627451 0 serum_phospholipids serum_phospholipids 0.00208 4.53E-05 up up no no up up 20:2/18:1-PE+blood 16:0/22:6-PE+blood 0.795488722 0.5 0.69025641 serum_phospholipids serum_phospholipids 0.00208 0.000934 up up no up up no 20:2/18:1-PE+blood 18:0-LPE+blood 0.615037594 0 0.481709402 serum_phospholipids serum_phospholipids 0.00208 0.491 up up no no no no 20:2/18:1-PE+blood 18:0/16:0-PC+blood -0.47518797 0 0 serum_phospholipids serum_phospholipids 0.00208 9.64E-07 up up no up up up 20:2/18:1-PE+blood 18:0/18:0-PE+blood 0.721804511 0.661764706 0.651965812 serum_phospholipids serum_phospholipids 0.00208 0.00896 up up no up up no 20:2/18:1-PE+blood 18:0/18:0-PS+blood 0.660150376 0.495098039 0.432478632 serum_phospholipids serum_phospholipids 0.00208 0.00617 up up no no up no 20:2/18:1-PE+blood 18:0/18:1-PE+blood 0.714285714 0.74754902 0.622564103 serum_phospholipids serum_phospholipids 0.00208 0.00716 up up no up up no 20:2/18:1-PE+blood 18:0/18:1-PG+blood 0.50075188 0.625 0.461880342 serum_phospholipids serum_phospholipids 0.00208 0.000842 up up no no up no 20:2/18:1-PE+blood 18:0/18:1-PI+blood 0 0.519607843 0 serum_phospholipids serum_phospholipids 0.00208 0.599 up up no no no no 20:2/18:1-PE+blood 18:0/18:2-PI+blood 0.589473684 0 0 serum_phospholipids serum_phospholipids 0.00208 0.179 up up no no no no 20:2/18:1-PE+blood 18:0/20:3-PC+blood 0 0.585784314 0.471452991 serum_phospholipids serum_phospholipids 0.00208 0.0682 up up no no up no 20:2/18:1-PE+blood 18:0/20:3-PI+blood 0 0.492647059 0 serum_phospholipids serum_phospholipids 0.00208 0.377 up up no no no no 20:2/18:1-PE+blood 18:0/20:4-PC+blood -0.487218045 -0.666666667 0 serum_phospholipids serum_phospholipids 0.00208 0.454 up up no no no no 20:2/18:1-PE+blood 18:0/20:5-PC+blood 0 -0.68872549 0 serum_phospholipids serum_phospholipids 0.00208 0.17 up up no no no no 20:2/18:1-PE+blood 18:0/22:6-PE+blood 0.681203008 0 0.520683761 serum_phospholipids serum_phospholipids 0.00208 0.00022 up up no up up no 20:2/18:1-PE+blood 18:1/16:0-PC+blood -0.654135338 0 0 serum_phospholipids serum_phospholipids 0.00208 2.43E-05 up up no no up up 20:2/18:1-PE+blood 18:1/16:0-PE+blood 0.70075188 0.705882353 0.76 serum_phospholipids serum_phospholipids 0.00208 0.000182 up up no up up no 20:2/18:1-PE+blood 18:1/16:0-PI+blood 0 0.509803922 0 serum_phospholipids serum_phospholipids 0.00208 0.793 up up no no no no 20:2/18:1-PE+blood 18:1/16:1-PE+blood 0.759398496 0.774509804 0.593846154 serum_phospholipids serum_phospholipids 0.00208 0.000184 up up no up up no 20:2/18:1-PE+blood 18:1/18:0-PE+blood 0.769924812 0.828431373 0.738803419 serum_phospholipids serum_phospholipids 0.00208 1.39E-06 up up no up up no 20:2/18:1-PE+blood 18:1/18:1-PE+blood 0.864661654 0.865196078 0.778461538 serum_phospholipids serum_phospholipids 0.00208 1.03E-05 up up no up up no 20:2/18:1-PE+blood 18:1/18:1-PG+blood 0 0.598039216 0 serum_phospholipids serum_phospholipids 0.00208 0.00352 up up no no up up 20:2/18:1-PE+blood 18:1/18:2-PE+blood 0.708270677 0.796568627 0.584957265 serum_phospholipids serum_phospholipids 0.00208 0.000293 up up no up up no 20:2/18:1-PE+blood 18:1/20:4-PC+blood 0 -0.578431373 0 serum_phospholipids serum_phospholipids 0.00208 0.582 up up no no no no 20:2/18:1-PE+blood 18:1/20:4-PE+blood 0.687218045 0.519607843 0.622564103 serum_phospholipids serum_phospholipids 0.00208 0.0578 up up no up no no 20:2/18:1-PE+blood 18:1/22:6-PE+blood 0.493233083 0 0 serum_phospholipids serum_phospholipids 0.00208 0.0047 up up no no up no 20:2/18:1-PE+blood 18:2-LPC+blood 0 0 -0.446837607 serum_phospholipids serum_phospholipids 0.00208 0.00743 up up no dn no up 20:2/18:1-PE+blood 18:2/18:2-PS+blood 0.691729323 0.708333333 0 serum_phospholipids serum_phospholipids 0.00208 0.00674 up up no up up no 20:2/18:1-PE+blood 18:3/16:0-PE+blood 0.822556391 0.661764706 0.61025641 serum_phospholipids serum_phospholipids 0.00208 0.00149 up up no up up no 20:2/18:1-PE+blood 18:3/18:2-PC+blood 0.457142857 0 0 serum_phospholipids serum_phospholipids 0.00208 0.0394 up up no no no up 20:2/18:1-PE+blood 20:0/20:4-PE+blood 0.636090226 0.671568627 0.803760684 serum_phospholipids serum_phospholipids 0.00208 0.00128 up up no up up no 20:2/18:1-PE+blood 20:1/20:4-PE+blood 0.52481203 0.666666667 0.771623932 serum_phospholipids serum_phospholipids 0.00208 0.0042 up up no up up no 20:2/18:1-PE+blood 20:2/18:0-PC+blood 0 0.578431373 0.483076923 serum_phospholipids serum_phospholipids 0.00208 0.0427 up up no no up no 20:2/18:3-PE+blood 14:0-LPC+blood -0.627067669 0 0 serum_phospholipids serum_phospholipids 0.0391 0.00689 up up no up up no 20:2/18:3-PE+blood 14:1/18:2-PG+blood -0.630075188 0 0 serum_phospholipids serum_phospholipids 0.0391 0.00259 up up no no up up 20:2/18:3-PE+blood 16:0/18:0-PS+blood 0.520300752 0.571078431 0 serum_phospholipids serum_phospholipids 0.0391 0.377 up up no no no no 20:2/18:3-PE+blood 16:0/18:1-PE+blood 0 0 0.488547009 serum_phospholipids serum_phospholipids 0.0391 0.000107 up up no up up no 20:2/18:3-PE+blood 16:0/20:4-PC+blood 0 0 0.433846154 serum_phospholipids serum_phospholipids 0.0391 0.0262 up up no no up no 20:2/18:3-PE+blood 16:0/20:4-PE+blood 0.535338346 0.632352941 0.675213675 serum_phospholipids serum_phospholipids 0.0391 0.00139 up up no up up no 20:2/18:3-PE+blood 16:0/20:5-PG+blood 0.559398496 0 0 serum_phospholipids serum_phospholipids 0.0391 0.00656 up up no no up no 20:2/18:3-PE+blood 16:0/22:6-PE+blood 0.559398496 0.691176471 0.592478632 serum_phospholipids serum_phospholipids 0.0391 0.000934 up up no up up no 20:2/18:3-PE+blood 16:1+blood 0 0.551470588 0 yes serum_phospholipids serum_fattyacid 0.0391 0.0186 up up no no no dn 20:2/18:3-PE+blood 18:0/20:4-PC+blood 0 0 0.490598291 serum_phospholipids serum_phospholipids 0.0391 0.454 up up no no no no 20:2/18:3-PE+blood 18:0/20:4-PI+blood 0 0.639705882 0 serum_phospholipids serum_phospholipids 0.0391 0.167 up up no no no no 20:2/18:3-PE+blood 18:0/22:6-PC+blood -0.521804511 0 0 serum_phospholipids serum_phospholipids 0.0391 0.0775 up up no no no up 20:2/18:3-PE+blood 18:0/22:6-PE+blood 0 0 0.515897436 serum_phospholipids serum_phospholipids 0.0391 0.00022 up up no up up no 20:2/18:3-PE+blood 18:1/16:0-PE+blood 0.488721805 0 0.530940171 serum_phospholipids serum_phospholipids 0.0391 0.000182 up up no up up no 20:2/18:3-PE+blood 18:1/16:1-PE+blood 0 0 0.455726496 serum_phospholipids serum_phospholipids 0.0391 0.000184 up up no up up no 20:2/18:3-PE+blood 18:1/18:0-PE+blood 0 0 0.541196581 serum_phospholipids serum_phospholipids 0.0391 1.39E-06 up up no up up no 20:2/18:3-PE+blood 18:1/18:0-PS+blood 0 0.531862745 0 serum_phospholipids serum_phospholipids 0.0391 0.193 up up no no no no 20:2/18:3-PE+blood 18:1/18:1-PE+blood 0 0 0.537094017 serum_phospholipids serum_phospholipids 0.0391 1.03E-05 up up no up up no 20:2/18:3-PE+blood 18:1/18:2-PE+blood 0.539849624 0 0.587008547 serum_phospholipids serum_phospholipids 0.0391 0.000293 up up no up up no 20:2/18:3-PE+blood 18:1/20:4-PC+blood 0 0 0.494017094 serum_phospholipids serum_phospholipids 0.0391 0.582 up up no no no no 20:2/18:3-PE+blood 18:1/20:4-PE+blood 0.741353383 0.759803922 0.805811966 serum_phospholipids serum_phospholipids 0.0391 0.0578 up up no up no no 20:2/18:3-PE+blood 18:1/22:6-PE+blood 0.642105263 0.512254902 0.417435897 serum_phospholipids serum_phospholipids 0.0391 0.0047 up up no no up no 20:2/18:3-PE+blood 18:1+blood 0 0.578431373 0 yes serum_phospholipids serum_fattyacid 0.0391 0.00202 up up no up no dn 20:2/18:3-PE+blood 18:2/20:4-PC+blood 0 0 0.550769231 serum_phospholipids serum_phospholipids 0.0391 0.0145 up up no no no up 20:2/18:3-PE+blood 18:3-LPC+blood 0 0 -0.476923077 serum_phospholipids serum_phospholipids 0.0391 0.147 up up no no no no 20:2/18:3-PE+blood 20:0/20:4-PE+blood 0.763909774 0 0.613675214 serum_phospholipids serum_phospholipids 0.0391 0.00128 up up no up up no 20:2/18:3-PE+blood 20:0/20:5-PC+blood 0 0 0.40991453 serum_phospholipids serum_phospholipids 0.0391 0.882 up up no no no no 20:2/18:3-PE+blood 20:1/20:4-PC+blood -0.529323308 0 0 serum_phospholipids serum_phospholipids 0.0391 0.0419 up up no no no up 20:2/18:3-PE+blood 20:1/20:4-PE+blood 0.757894737 0 0.629401709 serum_phospholipids serum_phospholipids 0.0391 0.0042 up up no up up no 20:2/18:3-PE+blood 20:2/18:1-PE+blood 0.454135338 0 0.53025641 serum_phospholipids serum_phospholipids 0.0391 0.00208 up up no up up no 20:2+blood 13-HODE+blood 0.448120301 0 0 serum_fattyacid serum_ARA 0.478 0.32 no no no no no no 20:2+blood 14:1/18:2-PG+blood 0 0.632352941 0 serum_fattyacid serum_phospholipids 0.478 0.00259 no no no no up up 20:2+blood 16:0-LPC+blood 0.508270677 0 0 serum_fattyacid serum_phospholipids 0.478 0.00456 no no no up up no 20:2+blood 16:0/14:0-PC+blood 0 0.50245098 0 serum_fattyacid serum_phospholipids 0.478 0.0206 no no no no up up 20:2+blood 16:0/18:2-PC+blood 0 0.485294118 0 serum_fattyacid serum_phospholipids 0.478 3.24E-06 no no no no up up 20:2+blood 16:0/20:3-PC+blood 0.454135338 0.617647059 0.457094017 serum_fattyacid serum_phospholipids 0.478 5.43E-06 no no no no up up 20:2+blood 16:0/20:5-PC+blood -0.693233083 0 -0.43042735 serum_fattyacid serum_phospholipids 0.478 0.628 no no no no no no 20:2+blood 16:1/18:2-PG+blood 0.460150376 0.578431373 0 serum_fattyacid serum_phospholipids 0.478 1.40E-08 no no no no up up 20:2+blood 18:0/18:0-PS+blood 0 0 -0.448888889 serum_fattyacid serum_phospholipids 0.478 0.00617 no no no no up no 20:2+blood 18:0/18:1-PC+blood 0 0 0.405811966 serum_fattyacid serum_phospholipids 0.478 0.393 no no no no no no 20:2+blood 18:0/18:1-PG+blood 0 0 -0.426324786 serum_fattyacid serum_phospholipids 0.478 0.000842 no no no no up no 20:2+blood 18:0/18:2-PC+blood 0 0.566176471 0 serum_fattyacid serum_phospholipids 0.478 1.74E-06 no no no no up up 20:2+blood 18:0/18:2-PI+blood 0 0.509803922 0 serum_fattyacid serum_phospholipids 0.478 0.179 no no no no no no 20:2+blood 18:0/20:2-PC+blood 0 0 0.588376068 serum_fattyacid serum_phospholipids 0.478 0.733 no no no no no no 20:2+blood 18:0/20:3-PI+blood 0.454135338 0 0 serum_fattyacid serum_phospholipids 0.478 0.377 no no no no no no 20:2+blood 18:1-LPC+blood 0.460150376 0 0.471452991 serum_fattyacid serum_phospholipids 0.478 0.179 no no no no no no 20:2+blood 18:1/16:0-PC+blood 0 0.485294118 0 serum_fattyacid serum_phospholipids 0.478 2.43E-05 no no no no up up 20:2+blood 18:1/18:0-PC+blood 0 0.583333333 0 serum_fattyacid serum_phospholipids 0.478 1.83E-06 no no no no up up 20:2+blood 18:1/18:1-PC+blood 0.454135338 0.642156863 0.472136752 serum_fattyacid serum_phospholipids 0.478 1.34E-05 no no no no up up 20:2+blood 18:1/18:2-PG+blood 0.484210526 0 0 serum_fattyacid serum_phospholipids 0.478 5.58E-07 no no no no up up 20:2+blood 18:1/18:2-PI+blood 0.458646617 0 0 serum_fattyacid serum_phospholipids 0.478 0.0164 no no no dn no up 20:2+blood 18:1/20:3-PC+blood 0.467669173 0.487745098 0.584957265 serum_fattyacid serum_phospholipids 0.478 0.00872 no no no no up up 20:2+blood 18:2-LPC+blood 0.621052632 0 0 serum_fattyacid serum_phospholipids 0.478 0.00743 no no no dn no up 20:2+blood 18:2-LPE+blood 0 0.588235294 0 serum_fattyacid serum_phospholipids 0.478 0.112 no no no no no no 20:2+blood 18:2/18:1-PC+blood 0.568421053 0 0 serum_fattyacid serum_phospholipids 0.478 2.30E-05 no no no dn up up 20:2+blood 18:2/18:2-PC+blood 0.535338346 0 0 serum_fattyacid serum_phospholipids 0.478 1.98E-05 no no no dn up up 20:2+blood 18:2n6c+blood 0.539849624 0.669117647 0.404444444 serum_fattyacid serum_fattyacid 0.478 0.15 no no no no no no 20:2+blood 18:3/16:0-PE+blood 0 0 -0.427008547 serum_fattyacid serum_phospholipids 0.478 0.00149 no no no up up no 20:2+blood 20:0-LPE+blood 0 0 0.425641026 serum_fattyacid serum_phospholipids 0.478 0.0615 no no no no no up 20:2+blood 20:0/20:5-PC+blood 0 -0.541666667 0 serum_fattyacid serum_phospholipids 0.478 0.882 no no no no no no 20:2+blood 20:1-LPC+blood 0 0 0.475555556 serum_fattyacid serum_phospholipids 0.478 0.217 no no no no no no 20:2+blood ACA+stool 0 0 0.465903824 serum_fattyacid stool_bileacids 0.478 0.417 no no no no no no 20:2+blood Adrenergic signaling in cardiomyocytes 0 0 -0.616923077 serum_fattyacid kegg 0.478 NA no no no no no up 20:2+blood AGE-RAGE signaling pathway in diabetic complications 0.471929825 0 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Alcoholism 0 0.541176471 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Aldosterone synthesis and secretion 0 0 -0.475384615 serum_fattyacid kegg 0.478 NA no no no no up up 20:2+blood Amoebiasis 0 0.564705882 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Amphetamine addiction 0 0 -0.455384615 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Apoptosis 0 0.629411765 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood B cell receptor signaling pathway 0 0.558823529 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Bacteroides 0 -0.536764706 0 LPS-producing serum_fattyacid Genus 0.478 0.000267 no no no dn dn up 20:2+blood Biosynthesis of cofactors 0 -0.579411765 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Calcium signaling pathway 0.512280702 0 -0.410769231 serum_fattyacid kegg 0.478 NA no no no no up up 20:2+blood cAMP signaling pathway 0 0.661764706 0 yes serum_fattyacid kegg 0.478 NA no no no no up up 20:2+blood Cell cycle 0 -0.726470588 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Cellular senescence 0 0.558823529 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood cGMP-PKG signaling pathway 0 0.55 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Chagas disease 0 0.602941176 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Chemokine signaling pathway 0 0.667647059 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Colorectal cancer 0.485964912 0 -0.473076923 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Cushing syndrome 0 0 -0.468461538 serum_fattyacid kegg 0.478 NA no no no no no up 20:2+blood Dopaminergic synapse 0 0 -0.549230769 serum_fattyacid kegg 0.478 NA no no no no up no 20:2+blood Epithelial cell signaling in Helicobacter pylori infection 0 0.576470588 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Epstein-Barr virus infection 0 0.585294118 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood ErbB signaling pathway 0.498245614 0 -0.402307692 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Estrogen signaling pathway 0 -0.635294118 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Fc gamma R-mediated phagocytosis 0 0 0.439230769 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Glioma 0.631578947 0 -0.432307692 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Glucagon signaling pathway 0 0 -0.610769231 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood "Glycine, serine and threonine metabolism" 0 -0.505882353 0 serum_fattyacid kegg 0.478 NA no no no no up no 20:2+blood GnRH signaling pathway 0 0 -0.453076923 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Human cytomegalovirus infection 0 0.647058824 0 serum_fattyacid kegg 0.478 NA no no no no no dn 20:2+blood Human immunodeficiency virus 1 infection 0 0.602941176 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Human papillomavirus infection 0 0.544117647 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood IL-17 signaling pathway 0 0.529411765 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Inflammatory mediator regulation of TRP channels 0 0 -0.499230769 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Kaposi sarcoma-associated herpesvirus infection 0 0.529411765 0 serum_fattyacid kegg 0.478 NA no no no no no dn 20:2+blood Lachnospira -0.479699248 0 0 butyrate-producing serum_fattyacid Genus 0.478 0.279 no no no no no no 20:2+blood Long-term depression 0 0.611764706 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Long-term potentiation 0.58245614 -0.626470588 -0.463846154 serum_fattyacid kegg 0.478 NA no no no no no up 20:2+blood Lysosome 0 0 0.433846154 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood MAPK signaling pathway 0 -0.502941176 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Melanogenesis 0 0 -0.412307692 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood mRNA surveillance pathway 0 -0.508823529 -0.516153846 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Natural killer cell mediated cytotoxicity 0 0.5 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Neurotrophin signaling pathway 0 0.535294118 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Oocyte meiosis 0 -0.6 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Osteoclast differentiation 0 0.520588235 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Pancreatic cancer 0.543859649 0 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Pathogenic Escherichia coli infection 0 0.520588235 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Phosphatidylinositol signaling system 0.540350877 0 -0.463076923 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Primary immunodeficiency 0 -0.752941176 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Progesterone-mediated oocyte maturation 0 -0.588235294 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Prolactin signaling pathway 0 0.5 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Protein processing in endoplasmic reticulum 0 -0.532352941 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Ras signaling pathway 0 -0.529411765 0 yes serum_fattyacid kegg 0.478 NA no no no no up up 20:2+blood Relaxin signaling pathway 0 0.635294118 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Renal cell carcinoma 0.536842105 0 -0.406923077 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Ribosome biogenesis in eukaryotes 0 -0.691176471 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood RNA degradation 0 0 -0.437692308 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Roseburia 0 0 -0.463247863 butyrate-producing serum_fattyacid Genus 0.478 0.495 no no no no no no 20:2+blood Signaling pathways regulating pluripotency of stem cells 0.515789474 0 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Spinocerebellar ataxia 0 -0.544117647 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Spliceosome 0 0 -0.451538462 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Staphylococcus aureus infection 0 0 0.563846154 serum_fattyacid kegg 0.478 NA no no no up no no 20:2+blood Systemic lupus erythematosus 0 0 0.452307692 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood TCA+stool 0 0.736363636 0 serum_fattyacid stool_bileacids 0.478 0.458 no no no no no no 20:2+blood Toll-like receptor signaling pathway 0 0.55 0 yes serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Toxoplasmosis 0 0 0.523076923 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Tuberculosis 0 0 0.474615385 serum_fattyacid kegg 0.478 NA no no no no no dn 20:2+blood VEGF signaling pathway 0.464912281 0 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Viral carcinogenesis 0 0.532352941 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Viral protein interaction with cytokine and cytokine receptor 0 0.641176471 0 serum_fattyacid kegg 0.478 NA no no no no no no 20:2+blood Wnt signaling pathway 0 -0.573529412 -0.51 serum_fattyacid kegg 0.478 NA no no no no no no 20:3-LPC+blood 13-HODE+blood 0.679699248 0 0 serum_phospholipids serum_ARA 0.0292 0.32 no up no no no no 20:3-LPC+blood 14:0-LPC+blood 0 0 0.519316239 serum_phospholipids serum_phospholipids 0.0292 0.00689 no up no up up no 20:3-LPC+blood 14:0/18:0-PC+blood 0 0.56372549 0.463931624 serum_phospholipids serum_phospholipids 0.0292 0.00289 no up no up up no 20:3-LPC+blood 14:1/18:2-PG+blood 0 0 0.411282051 serum_phospholipids serum_phospholipids 0.0292 0.00259 no up no no up up 20:3-LPC+blood 16:0-LPC+blood 0 0 0.526837607 serum_phospholipids serum_phospholipids 0.0292 0.00456 no up no up up no 20:3-LPC+blood 16:0-LPE+blood 0 0 0.591111111 serum_phospholipids serum_phospholipids 0.0292 0.0711 no up no up up no 20:3-LPC+blood 16:0/16:0-PC+blood -0.49924812 0 0 serum_phospholipids serum_phospholipids 0.0292 0.00079 no up no no up up 20:3-LPC+blood 16:0/16:1-PC+blood 0 0.571078431 0.465982906 serum_phospholipids serum_phospholipids 0.0292 0.00283 no up no up up no 20:3-LPC+blood 16:0/16:1-PI+blood 0 0.644607843 0.488547009 serum_phospholipids serum_phospholipids 0.0292 0.262 no up no no no no 20:3-LPC+blood 16:0/18:0-PC+blood -0.487218045 0 0 serum_phospholipids serum_phospholipids 0.0292 0.521 no up no no no no 20:3-LPC+blood 16:0/18:2-PI+blood 0 0 0.470769231 serum_phospholipids serum_phospholipids 0.0292 0.269 no up no no no no 20:3-LPC+blood 16:0/18:3-PC+blood 0 0 0.418803419 serum_phospholipids serum_phospholipids 0.0292 0.00216 no up no no up up 20:3-LPC+blood 16:0/20:3-PC+blood 0 0.534313725 0.561709402 serum_phospholipids serum_phospholipids 0.0292 5.43E-06 no up no no up up 20:3-LPC+blood 16:0/20:4-PI+blood 0 0 0.43042735 serum_phospholipids serum_phospholipids 0.0292 0.558 no up no no no no 20:3-LPC+blood 16:0/20:5-PC+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.0292 0.628 no up no no no no 20:3-LPC+blood 16:0/22:0-PE+blood -0.452631579 0 0 serum_phospholipids serum_phospholipids 0.0292 0.00839 no up no dn no up 20:3-LPC+blood 16:0/22:6-PC+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.0292 4.53E-05 no up no no up up 20:3-LPC+blood 16:1/16:0-PC+blood 0 0 -0.475555556 serum_phospholipids serum_phospholipids 0.0292 0.0215 no up no no up up 20:3-LPC+blood 18:0-LPA+blood 0 0 0.474188034 serum_phospholipids serum_phospholipids 0.0292 0.0725 no up no no dn no 20:3-LPC+blood 18:0/18:1-PI+blood 0 0.656862745 0 serum_phospholipids serum_phospholipids 0.0292 0.599 no up no no no no 20:3-LPC+blood 18:0/20:2-PC+blood 0 0.487745098 0 serum_phospholipids serum_phospholipids 0.0292 0.733 no up no no no no 20:3-LPC+blood 18:0/20:3-PC+blood 0 0.700980392 0.730598291 serum_phospholipids serum_phospholipids 0.0292 0.0682 no up no no up no 20:3-LPC+blood 18:0/20:3-PI+blood 0.469172932 0.661764706 0 serum_phospholipids serum_phospholipids 0.0292 0.377 no up no no no no 20:3-LPC+blood 18:1-LPE+blood 0 0 0.451623932 serum_phospholipids serum_phospholipids 0.0292 0.117 no up no no no no 20:3-LPC+blood 18:1/18:1-PC+blood 0 0.632352941 0.561709402 serum_phospholipids serum_phospholipids 0.0292 1.34E-05 no up no no up up 20:3-LPC+blood 18:1/18:1-PI+blood 0 0.625 0 serum_phospholipids serum_phospholipids 0.0292 0.111 no up no dn no no 20:3-LPC+blood 18:1/20:3-PC+blood 0 0.732843137 0.555555556 serum_phospholipids serum_phospholipids 0.0292 0.00872 no up no no up up 20:3-LPC+blood 18:2/16:0-PC+blood 0 -0.676470588 0 serum_phospholipids serum_phospholipids 0.0292 8.67E-05 no up no no up up 20:3-LPC+blood 18:2/18:2-PS+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 0.0292 0.00674 no up no up up no 20:3-LPC+blood 18:3-LPC+blood 0 -0.602941176 0 serum_phospholipids serum_phospholipids 0.0292 0.147 no up no no no no 20:3-LPC+blood 18:3n3+blood 0 -0.678921569 -0.435897436 serum_phospholipids serum_fattyacid 0.0292 0.291 no up no no no no 20:3-LPC+blood 18:3n6+blood 0 0 0.494700855 serum_phospholipids serum_fattyacid 0.0292 0.0463 no up no up no dn 20:3-LPC+blood 20:0+blood 0 0 0.494700855 yes serum_phospholipids serum_fattyacid 0.0292 0.000278 no up no dn no up 20:3-LPC+blood 20:2/18:0-PC+blood 0 0.68872549 0.745641026 serum_phospholipids serum_phospholipids 0.0292 0.0427 no up no no up no 20:3-LPC+blood 20:2/18:1-PE+blood 0 0 0.498119658 serum_phospholipids serum_phospholipids 0.0292 0.00208 no up no up up no 20:3-LPE+blood 12-ketoDCA+blood 0 0 -0.609974118 serum_phospholipids serum_bileacids 0.084 0.517 no up no no no no 20:3-LPE+blood "12,13-EPOME+blood" 0 0 -0.439407315 serum_phospholipids serum_ARA 0.084 0.901 no up no no no no 20:3-LPE+blood 14:0/18:0-PC+blood 0 0.639705882 0 serum_phospholipids serum_phospholipids 0.084 0.00289 no up no up up no 20:3-LPE+blood 16:0-LPE+blood 0 0 0.500854701 serum_phospholipids serum_phospholipids 0.084 0.0711 no up no up up no 20:3-LPE+blood 16:0/16:1-PC+blood 0 0.605392157 0 serum_phospholipids serum_phospholipids 0.084 0.00283 no up no up up no 20:3-LPE+blood 16:0/16:1-PI+blood 0 0.50245098 0 serum_phospholipids serum_phospholipids 0.084 0.262 no up no no no no 20:3-LPE+blood 16:0/20:3-PC+blood 0 0 0.528888889 serum_phospholipids serum_phospholipids 0.084 5.43E-06 no up no no up up 20:3-LPE+blood 16:0/20:5-PC+blood 0 -0.595588235 0 serum_phospholipids serum_phospholipids 0.084 0.628 no up no no no no 20:3-LPE+blood 16:0/22:0-PE+blood -0.810526316 -0.551470588 0 serum_phospholipids serum_phospholipids 0.084 0.00839 no up no dn no up 20:3-LPE+blood 16:0/22:6-PC+blood -0.57443609 -0.529411765 0 serum_phospholipids serum_phospholipids 0.084 4.53E-05 no up no no up up 20:3-LPE+blood 16:0+blood 0.523308271 0 0 yes serum_phospholipids serum_fattyacid 0.084 0.00876 no up no up no no 20:3-LPE+blood 16:1/16:1-PC+blood 0 -0.531862745 0 serum_phospholipids serum_phospholipids 0.084 0.0177 no up no no no up 20:3-LPE+blood 18:0-LPE+blood 0 0 0.448888889 serum_phospholipids serum_phospholipids 0.084 0.491 no up no no no no 20:3-LPE+blood 18:0/20:3-PC+blood 0 0 0.535042735 serum_phospholipids serum_phospholipids 0.084 0.0682 no up no no up no 20:3-LPE+blood 18:0/20:5-PC+blood -0.508270677 0 0 serum_phospholipids serum_phospholipids 0.084 0.17 no up no no no no 20:3-LPE+blood 18:0/22:6-PC+blood -0.572932331 -0.504901961 -0.478290598 serum_phospholipids serum_phospholipids 0.084 0.0775 no up no no no up 20:3-LPE+blood 18:0/22:6-PE+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.084 0.00022 no up no up up no 20:3-LPE+blood 18:0/22:6-PI+blood 0 -0.549019608 -0.445470085 serum_phospholipids serum_phospholipids 0.084 0.425 no up no no no no 20:3-LPE+blood 18:1-LPE+blood 0.520300752 0 0.549401709 serum_phospholipids serum_phospholipids 0.084 0.117 no up no no no no 20:3-LPE+blood 18:1/18:1-PC+blood 0 0.517156863 0.511794872 serum_phospholipids serum_phospholipids 0.084 1.34E-05 no up no no up up 20:3-LPE+blood 18:1/20:3-PC+blood 0 0.524509804 0.55965812 serum_phospholipids serum_phospholipids 0.084 0.00872 no up no no up up 20:3-LPE+blood 18:1/20:4-PI+blood -0.482706767 0 0 serum_phospholipids serum_phospholipids 0.084 0.192 no up no no no no 20:3-LPE+blood 18:2-LPE+blood 0 0.68627451 0 serum_phospholipids serum_phospholipids 0.084 0.112 no up no no no no 20:3-LPE+blood 18:2/18:2-PS+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.084 0.00674 no up no up up no 20:3-LPE+blood 18:2/20:4-PC+blood -0.541353383 0 0 serum_phospholipids serum_phospholipids 0.084 0.0145 no up no no no up 20:3-LPE+blood 18:3n3+blood 0 -0.698529412 0 serum_phospholipids serum_fattyacid 0.084 0.291 no up no no no no 20:3-LPE+blood 20:0-LPC+blood 0 0 0.469401709 serum_phospholipids serum_phospholipids 0.084 0.199 no up no no no no 20:3-LPE+blood 20:0+blood 0 0 0.439316239 yes serum_phospholipids serum_fattyacid 0.084 0.000278 no up no dn no up 20:3-LPE+blood 20:1/20:4-PC+blood -0.554887218 0 0 serum_phospholipids serum_phospholipids 0.084 0.0419 no up no no no up 20:3-LPE+blood 20:2-LPC+blood 0 0 0.412649573 serum_phospholipids serum_phospholipids 0.084 0.119 no up no no no up 20:3-LPE+blood 20:2/18:0-PC+blood 0 0 0.521367521 serum_phospholipids serum_phospholipids 0.084 0.0427 no up no no up no 20:3-LPE+blood 20:3-LPC+blood 0.533834586 0.524509804 0.714188034 serum_phospholipids serum_phospholipids 0.084 0.0292 no up no no up no 20:3/16:0-PC+blood 16:0-LPC+blood 0 0 -0.537777778 serum_phospholipids serum_phospholipids 0.00405 0.00456 no up up up up no 20:3/16:0-PC+blood 16:0-LPE+blood -0.583458647 0 0 serum_phospholipids serum_phospholipids 0.00405 0.0711 no up up up up no 20:3/16:0-PC+blood 16:0/14:0-PC+blood 0.705263158 0 0.623931624 serum_phospholipids serum_phospholipids 0.00405 0.0206 no up up no up up 20:3/16:0-PC+blood 16:0/16:0-PC+blood 0 0 0.436581197 serum_phospholipids serum_phospholipids 0.00405 0.00079 no up up no up up 20:3/16:0-PC+blood 16:0/16:0-PI+blood -0.657142857 -0.620098039 0 serum_phospholipids serum_phospholipids 0.00405 0.358 no up up no no no 20:3/16:0-PC+blood 16:0/16:1-PI+blood -0.657142857 -0.588235294 0 serum_phospholipids serum_phospholipids 0.00405 0.262 no up up no no no 20:3/16:0-PC+blood 16:0/18:1-PC+blood 0.807518797 0.639705882 0.403760684 serum_phospholipids serum_phospholipids 0.00405 6.15E-07 no up up up up up 20:3/16:0-PC+blood 16:0/18:1-PE+blood -0.622556391 -0.485294118 0 serum_phospholipids serum_phospholipids 0.00405 0.000107 no up up up up no 20:3/16:0-PC+blood 16:0/18:2-PC+blood 0.705263158 0.575980392 0.611623932 serum_phospholipids serum_phospholipids 0.00405 3.24E-06 no up up no up up 20:3/16:0-PC+blood 16:0/18:2-PI+blood -0.669172932 -0.708333333 0 serum_phospholipids serum_phospholipids 0.00405 0.269 no up up no no no 20:3/16:0-PC+blood 16:0/20:3-PC+blood 0.598496241 0 0.460512821 serum_phospholipids serum_phospholipids 0.00405 5.43E-06 no up up no up up 20:3/16:0-PC+blood 16:0/20:4-PC+blood 0.972932331 0.985294118 0.987692308 serum_phospholipids serum_phospholipids 0.00405 0.0262 no up up no up no 20:3/16:0-PC+blood 16:0/20:4-PI+blood -0.52481203 -0.678921569 0 serum_phospholipids serum_phospholipids 0.00405 0.558 no up up no no no 20:3/16:0-PC+blood 16:0/20:5-PG+blood 0.551879699 0 0 serum_phospholipids serum_phospholipids 0.00405 0.00656 no up up no up no 20:3/16:0-PC+blood 16:0/22:6-PC+blood 0 0.776960784 0 serum_phospholipids serum_phospholipids 0.00405 4.53E-05 no up up no up up 20:3/16:0-PC+blood 16:0+blood 0 0.482843137 0 yes serum_phospholipids serum_fattyacid 0.00405 0.00876 no up up up no no 20:3/16:0-PC+blood 16:1/16:0-PC+blood 0.633082707 0.588235294 0.520683761 serum_phospholipids serum_phospholipids 0.00405 0.0215 no up up no up up 20:3/16:0-PC+blood 16:1/16:1-PC+blood 0.646616541 0 0 serum_phospholipids serum_phospholipids 0.00405 0.0177 no up up no no up 20:3/16:0-PC+blood 16:1/18:1-PG+blood 0.49924812 0 0 serum_phospholipids serum_phospholipids 0.00405 3.21E-05 no up up no up up 20:3/16:0-PC+blood 16:1/18:2-PG+blood 0.603007519 0 0 serum_phospholipids serum_phospholipids 0.00405 1.40E-08 no up up no up up 20:3/16:0-PC+blood 18:0-LPA+blood 0 0 -0.419487179 serum_phospholipids serum_phospholipids 0.00405 0.0725 no up up no dn no 20:3/16:0-PC+blood 18:0-LPE+blood -0.497744361 0 0 serum_phospholipids serum_phospholipids 0.00405 0.491 no up up no no no 20:3/16:0-PC+blood 18:0/16:0-PC+blood 0.777443609 0.683823529 0 serum_phospholipids serum_phospholipids 0.00405 9.64E-07 no up up up up up 20:3/16:0-PC+blood 18:0/18:0-PE+blood -0.557894737 -0.681372549 0 serum_phospholipids serum_phospholipids 0.00405 0.00896 no up up up up no 20:3/16:0-PC+blood 18:0/18:1-PE+blood -0.584962406 -0.713235294 0 serum_phospholipids serum_phospholipids 0.00405 0.00716 no up up up up no 20:3/16:0-PC+blood 18:0/18:2-PC+blood 0.590977444 0 0.608888889 serum_phospholipids serum_phospholipids 0.00405 1.74E-06 no up up no up up 20:3/16:0-PC+blood 18:0/20:4-PC+blood 0.879699248 0.843137255 0.900854701 serum_phospholipids serum_phospholipids 0.00405 0.454 no up up no no no 20:3/16:0-PC+blood 18:0/20:5-PC+blood 0 0.691176471 0.667008547 serum_phospholipids serum_phospholipids 0.00405 0.17 no up up no no no 20:3/16:0-PC+blood 18:0/22:6-PE+blood -0.541353383 0 0 serum_phospholipids serum_phospholipids 0.00405 0.00022 no up up up up no 20:3/16:0-PC+blood 18:0/22:6-PI+blood -0.536842105 0 0 serum_phospholipids serum_phospholipids 0.00405 0.425 no up up no no no 20:3/16:0-PC+blood 18:1/16:0-PC+blood 0.730827068 0.580882353 0.610940171 serum_phospholipids serum_phospholipids 0.00405 2.43E-05 no up up no up up 20:3/16:0-PC+blood 18:1/16:0-PE+blood -0.484210526 -0.531862745 0 serum_phospholipids serum_phospholipids 0.00405 0.000182 no up up up up no 20:3/16:0-PC+blood 18:1/16:0-PI+blood 0 -0.740196078 0 serum_phospholipids serum_phospholipids 0.00405 0.793 no up up no no no 20:3/16:0-PC+blood 18:1/16:1-PE+blood -0.646616541 -0.514705882 0 serum_phospholipids serum_phospholipids 0.00405 0.000184 no up up up up no 20:3/16:0-PC+blood 18:1/18:0-PC+blood 0.592481203 0 0.603418803 serum_phospholipids serum_phospholipids 0.00405 1.83E-06 no up up no up up 20:3/16:0-PC+blood 18:1/18:0-PE+blood -0.562406015 -0.615196078 0 serum_phospholipids serum_phospholipids 0.00405 1.39E-06 no up up up up no 20:3/16:0-PC+blood 18:1/18:1-PC+blood 0.581954887 0 0 serum_phospholipids serum_phospholipids 0.00405 1.34E-05 no up up no up up 20:3/16:0-PC+blood 18:1/18:1-PE+blood -0.541353383 -0.531862745 0 serum_phospholipids serum_phospholipids 0.00405 1.03E-05 no up up up up no 20:3/16:0-PC+blood 18:1/18:1-PI+blood 0 -0.541666667 0 serum_phospholipids serum_phospholipids 0.00405 0.111 no up up dn no no 20:3/16:0-PC+blood 18:1/18:2-PE+blood -0.554887218 -0.732843137 0 serum_phospholipids serum_phospholipids 0.00405 0.000293 no up up up up no 20:3/16:0-PC+blood 18:1/18:2-PG+blood 0.556390977 0 0 serum_phospholipids serum_phospholipids 0.00405 5.58E-07 no up up no up up 20:3/16:0-PC+blood 18:1/20:3-PC+blood 0 0 0.495384615 serum_phospholipids serum_phospholipids 0.00405 0.00872 no up up no up up 20:3/16:0-PC+blood 18:1/20:4-PC+blood 0.655639098 0.602941176 0.764786325 serum_phospholipids serum_phospholipids 0.00405 0.582 no up up no no no 20:3/16:0-PC+blood 18:1/20:4-PI+blood 0 0 0.567179487 serum_phospholipids serum_phospholipids 0.00405 0.192 no up up no no no 20:3/16:0-PC+blood 18:2-LPA+blood 0.545864662 0 0 serum_phospholipids serum_phospholipids 0.00405 0.00684 no up up dn no up 20:3/16:0-PC+blood 18:2/16:0-PC+blood 0.601503759 0.605392157 0.59042735 serum_phospholipids serum_phospholipids 0.00405 8.67E-05 no up up no up up 20:3/16:0-PC+blood 18:2/20:4-PC+blood 0 0.482843137 0.427008547 serum_phospholipids serum_phospholipids 0.00405 0.0145 no up up no no up 20:3/16:0-PC+blood 18:3/16:0-PE+blood -0.670676692 -0.700980392 0 serum_phospholipids serum_phospholipids 0.00405 0.00149 no up up up up no 20:3/16:0-PC+blood 20:0-LPE+blood -0.490225564 -0.539215686 0 serum_phospholipids serum_phospholipids 0.00405 0.0615 no up up no no up 20:3/16:0-PC+blood 20:0/20:4-PE+blood 0 -0.512254902 0 serum_phospholipids serum_phospholipids 0.00405 0.00128 no up up up up no 20:3/16:0-PC+blood 20:0/20:5-PC+blood 0.446616541 0 0.638290598 serum_phospholipids serum_phospholipids 0.00405 0.882 no up up no no no 20:3/16:0-PC+blood 20:1-LPE+blood 0 0.507352941 0 serum_phospholipids serum_phospholipids 0.00405 0.465 no up up no no no 20:3/16:0-PC+blood 20:1/20:4-PC+blood 0 0 0.415384615 serum_phospholipids serum_phospholipids 0.00405 0.0419 no up up no no up 20:3/16:0-PC+blood 20:2/18:1-PE+blood -0.601503759 -0.647058824 0 serum_phospholipids serum_phospholipids 0.00405 0.00208 no up up up up no 20:3/16:0-PC+blood 20:2/18:3-PE+blood 0 0 0.402393162 serum_phospholipids serum_phospholipids 0.00405 0.0391 no up up up up no 20:3/16:0-PC+blood Alistipes 0.51924898 0 0 serum_phospholipids Genus 0.00405 0.0114 no up up no up no 20:3/16:0-PC+blood Amyotrophic lateral sclerosis 0 0 -0.447692308 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Asthma 0 0 -0.472307692 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Autophagy - animal 0 0 0.476153846 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Axon guidance 0 -0.526470588 0 serum_phospholipids kegg 0.00405 NA no up up no up up 20:3/16:0-PC+blood Cardiac muscle contraction 0 0 -0.468461538 serum_phospholipids kegg 0.00405 NA no up up no no up 20:3/16:0-PC+blood Cytokine-cytokine receptor interaction 0 0 -0.406153846 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Diabetic cardiomyopathy 0 0 -0.496923077 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Dilated cardiomyopathy 0 0 -0.487692308 serum_phospholipids kegg 0.00405 NA no up up no up up 20:3/16:0-PC+blood Gastric acid secretion 0 0 -0.493846154 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood HDCA+stool 0.675824176 0 0 serum_phospholipids stool_bileacids 0.00405 0.176 no up up no no no 20:3/16:0-PC+blood Hematopoietic cell lineage 0 0 -0.475384615 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Hepatocellular carcinoma 0 0 -0.428461538 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Hippo signaling pathway 0 0 -0.403076923 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Huntington disease 0 0 -0.422307692 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Inflammatory bowel disease 0 0 -0.494615385 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Intestinal immune network for IgA production 0 0 -0.401538462 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Lachnospira 0 0 0.528767898 butyrate-producing serum_phospholipids Genus 0.00405 0.279 no up up no no no 20:3/16:0-PC+blood MAPK signaling pathway 0 0 0.401538462 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Non-alcoholic fatty liver disease 0 0 -0.459230769 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Oxidative phosphorylation 0 0 -0.456923077 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Prion disease 0 0 -0.480769231 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Renal cell carcinoma 0 -0.529411765 0 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Th1 and Th2 cell differentiation 0.547368421 0 0 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Th17 cell differentiation 0.494736842 0 0 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Thermogenesis 0 0 -0.470769231 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Thyroid hormone signaling pathway 0 0 -0.528461538 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Vasopressin-regulated water reabsorption 0 0 -0.425384615 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/16:0-PC+blood Vibrio cholerae infection 0 0 -0.415384615 serum_phospholipids kegg 0.00405 NA no up up no no no 20:3/18:0-PC+blood "12,13-EPOME+blood" 0 0 -0.403895711 serum_phospholipids serum_ARA 0.296 0.901 no no no no no no 20:3/18:0-PC+blood 14:0-LPC+blood 0 -0.693627451 -0.504957265 serum_phospholipids serum_phospholipids 0.296 0.00689 no no no up up no 20:3/18:0-PC+blood 14:0/20:4-PC+blood 0.506766917 0 0 serum_phospholipids serum_phospholipids 0.296 0.486 no no no no no no 20:3/18:0-PC+blood 14:0+blood 0 -0.558823529 0 yes serum_phospholipids serum_fattyacid 0.296 0.00572 no no no up no dn 20:3/18:0-PC+blood 14:1/18:2-PG+blood 0 -0.541666667 -0.483076923 serum_phospholipids serum_phospholipids 0.296 0.00259 no no no no up up 20:3/18:0-PC+blood 16:0/14:0-PC+blood 0 0 0.64991453 serum_phospholipids serum_phospholipids 0.296 0.0206 no no no no up up 20:3/18:0-PC+blood 16:0/16:0-PC+blood 0.684210526 0 0.540512821 serum_phospholipids serum_phospholipids 0.296 0.00079 no no no no up up 20:3/18:0-PC+blood 16:0/16:0-PI+blood 0 -0.495098039 0 serum_phospholipids serum_phospholipids 0.296 0.358 no no no no no no 20:3/18:0-PC+blood 16:0/18:0-PC+blood 0.62556391 0.487745098 0.460512821 serum_phospholipids serum_phospholipids 0.296 0.521 no no no no no no 20:3/18:0-PC+blood 16:0/18:1-PC+blood 0 0.507352941 0 serum_phospholipids serum_phospholipids 0.296 6.15E-07 no no no up up up 20:3/18:0-PC+blood 16:0/18:2-PC+blood 0 0 0.447521368 serum_phospholipids serum_phospholipids 0.296 3.24E-06 no no no no up up 20:3/18:0-PC+blood 16:0/18:3-PC+blood 0.547368421 0 0 serum_phospholipids serum_phospholipids 0.296 0.00216 no no no no up up 20:3/18:0-PC+blood 16:0/20:4-PC+blood 0 0.590686275 0 serum_phospholipids serum_phospholipids 0.296 0.0262 no no no no up no 20:3/18:0-PC+blood 16:0/22:0-PE+blood 0 0 0.502905983 serum_phospholipids serum_phospholipids 0.296 0.00839 no no no dn no up 20:3/18:0-PC+blood 16:0/22:6-PC+blood 0.610526316 0.725490196 0.596581197 serum_phospholipids serum_phospholipids 0.296 4.53E-05 no no no no up up 20:3/18:0-PC+blood 16:1/16:0-PC+blood 0.613533835 0.713235294 0.667692308 serum_phospholipids serum_phospholipids 0.296 0.0215 no no no no up up 20:3/18:0-PC+blood 16:1/16:1-PC+blood 0.72481203 0.745098039 0.645128205 serum_phospholipids serum_phospholipids 0.296 0.0177 no no no no no up 20:3/18:0-PC+blood 18:0-LPA+blood 0 0 -0.533675214 serum_phospholipids serum_phospholipids 0.296 0.0725 no no no no dn no 20:3/18:0-PC+blood 18:0/16:0-PC+blood 0 0.517156863 0 serum_phospholipids serum_phospholipids 0.296 9.64E-07 no no no up up up 20:3/18:0-PC+blood 18:0/18:0-PC+blood 0 0 0.40991453 serum_phospholipids serum_phospholipids 0.296 0.426 no no no no no no 20:3/18:0-PC+blood 18:0/18:0-PE+blood 0 0 -0.548717949 serum_phospholipids serum_phospholipids 0.296 0.00896 no no no up up no 20:3/18:0-PC+blood 18:0/18:0-PS+blood 0.615037594 0 -0.404444444 serum_phospholipids serum_phospholipids 0.296 0.00617 no no no no up no 20:3/18:0-PC+blood 18:0/18:1-PE+blood 0 -0.492647059 -0.58017094 serum_phospholipids serum_phospholipids 0.296 0.00716 no no no up up no 20:3/18:0-PC+blood 18:0/18:1-PG+blood 0 -0.50245098 -0.524102564 serum_phospholipids serum_phospholipids 0.296 0.000842 no no no no up no 20:3/18:0-PC+blood 18:0/18:2-PC+blood 0.445112782 0 0.628717949 serum_phospholipids serum_phospholipids 0.296 1.74E-06 no no no no up up 20:3/18:0-PC+blood 18:0/20:4-PC+blood 0 0.683823529 0 serum_phospholipids serum_phospholipids 0.296 0.454 no no no no no no 20:3/18:0-PC+blood 18:0/20:5-PC+blood 0 0 0.45025641 serum_phospholipids serum_phospholipids 0.296 0.17 no no no no no no 20:3/18:0-PC+blood 18:0/22:6-PA+blood 0.676691729 0.634803922 0 serum_phospholipids serum_phospholipids 0.296 0.22 no no no no no no 20:3/18:0-PC+blood 18:0/22:6-PC+blood 0 0.526960784 0.440683761 serum_phospholipids serum_phospholipids 0.296 0.0775 no no no no no up 20:3/18:0-PC+blood 18:1-LPE+blood -0.630075188 0 0 serum_phospholipids serum_phospholipids 0.296 0.117 no no no no no no 20:3/18:0-PC+blood 18:1/16:0-PC+blood 0 0 0.447521368 serum_phospholipids serum_phospholipids 0.296 2.43E-05 no no no no up up 20:3/18:0-PC+blood 18:1/16:0-PE+blood 0 0 -0.501538462 serum_phospholipids serum_phospholipids 0.296 0.000182 no no no up up no 20:3/18:0-PC+blood 18:1/18:0-PC+blood 0 0 0.643760684 serum_phospholipids serum_phospholipids 0.296 1.83E-06 no no no no up up 20:3/18:0-PC+blood 18:1/18:0-PE+blood 0 -0.514705882 -0.500854701 serum_phospholipids serum_phospholipids 0.296 1.39E-06 no no no up up no 20:3/18:0-PC+blood 18:1/18:0-PS+blood 0.551879699 0 0 serum_phospholipids serum_phospholipids 0.296 0.193 no no no no no no 20:3/18:0-PC+blood 18:1/18:1-PE+blood 0 0 -0.472820513 serum_phospholipids serum_phospholipids 0.296 1.03E-05 no no no up up no 20:3/18:0-PC+blood 18:1/18:2-PE+blood 0 0 -0.48034188 serum_phospholipids serum_phospholipids 0.296 0.000293 no no no up up no 20:3/18:0-PC+blood 18:1/20:4-PC+blood 0 0.593137255 0 serum_phospholipids serum_phospholipids 0.296 0.582 no no no no no no 20:3/18:0-PC+blood 18:2/16:0-PC+blood 0 0 0.492649573 serum_phospholipids serum_phospholipids 0.296 8.67E-05 no no no no up up 20:3/18:0-PC+blood 18:3n3+blood 0.479699248 0 0 serum_phospholipids serum_fattyacid 0.296 0.291 no no no no no no 20:3/18:0-PC+blood 20:0/20:4-PE+blood 0 -0.553921569 -0.405128205 serum_phospholipids serum_phospholipids 0.296 0.00128 no no no up up no 20:3/18:0-PC+blood 20:0/20:5-PC+blood 0.50075188 0.524509804 0 serum_phospholipids serum_phospholipids 0.296 0.882 no no no no no no 20:3/18:0-PC+blood 20:0+blood -0.476691729 0 0 yes serum_phospholipids serum_fattyacid 0.296 0.000278 no no no dn no up 20:3/18:0-PC+blood 20:1-LPC+blood 0 0 0.417435897 serum_phospholipids serum_phospholipids 0.296 0.217 no no no no no no 20:3/18:0-PC+blood 20:1-LPE+blood 0 0.487745098 0 serum_phospholipids serum_phospholipids 0.296 0.465 no no no no no no 20:3/18:0-PC+blood 20:1/20:4-PC+blood 0.446616541 0.625 0.521367521 serum_phospholipids serum_phospholipids 0.296 0.0419 no no no no no up 20:3/18:0-PC+blood 20:2-LPC+blood 0 0.526960784 0.457094017 serum_phospholipids serum_phospholipids 0.296 0.119 no no no no no up 20:3/18:0-PC+blood 20:2/18:1-PE+blood 0 0 -0.405128205 serum_phospholipids serum_phospholipids 0.296 0.00208 no no no up up no 20:3/18:0-PC+blood 20:3/16:0-PC+blood 0 0.585784314 0 serum_phospholipids serum_phospholipids 0.296 0.00405 no no no no up up 20:3/18:0-PC+blood Amphetamine addiction -0.561403509 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Axon guidance 0 -0.5 0 serum_phospholipids kegg 0.296 NA no no no no up up 20:3/18:0-PC+blood Bacteroides 0 0.573529412 0 LPS-producing serum_phospholipids Genus 0.296 0.000267 no no no dn dn up 20:3/18:0-PC+blood Biosynthesis of amino acids 0.547368421 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood cAMP signaling pathway -0.464912281 0 0 yes serum_phospholipids kegg 0.296 NA no no no no up up 20:3/18:0-PC+blood Carbon metabolism 0.512280702 0 0.458461538 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Choline metabolism in cancer 0 0 -0.418461538 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Cushing syndrome -0.496491228 0 0 serum_phospholipids kegg 0.296 NA no no no no no up 20:3/18:0-PC+blood DCA+stool 0 0 -0.664661654 serum_phospholipids stool_bileacids 0.296 0.195 no no no no no no 20:3/18:0-PC+blood Dopaminergic synapse -0.614035088 0 0 serum_phospholipids kegg 0.296 NA no no no no up no 20:3/18:0-PC+blood GCDCA+stool 0 0 0.452631579 yes serum_phospholipids stool_bileacids 0.296 0.0471 no no no no dn no 20:3/18:0-PC+blood GDCA+stool 0 0 0.525603006 serum_phospholipids stool_bileacids 0.296 0.656 no no no no no no 20:3/18:0-PC+blood Glioma 0 -0.594117647 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Glycolysis / Gluconeogenesis 0 0 0.429230769 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood HCA+stool 0.593406593 0 0 serum_phospholipids stool_bileacids 0.296 0.155 no no no no no no 20:3/18:0-PC+blood L-Phenylalanine+stool 0 0 0.45112782 serum_phospholipids stool_cometabolism 0.296 0.398 no no no no no no 20:3/18:0-PC+blood L-Tryptophan+stool 0 0 0.445112782 serum_phospholipids stool_cometabolism 0.296 0.557 no no no no no no 20:3/18:0-PC+blood LCA+stool 0 0 -0.488721805 serum_phospholipids stool_bileacids 0.296 0.314 no no no no no no 20:3/18:0-PC+blood Lysosome 0.457894737 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Mineral absorption -0.547368421 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Mitophagy - animal -0.554385965 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Necroptosis -0.580701754 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood NOD-like receptor signaling pathway 0.487719298 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood nutriCA+stool 0.56043956 0 0 serum_phospholipids stool_bileacids 0.296 0.481 no no no no no no 20:3/18:0-PC+blood Pancreatic cancer 0 0 -0.526153846 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Pancreatic secretion -0.484210526 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood "Parathyroid hormone synthesis, secretion and action" -0.510526316 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Parkinson disease -0.585964912 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Pathways of neurodegeneration - multiple diseases -0.592982456 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Peroxisome 0.501754386 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Pertussis 0.471929825 0 0 serum_phospholipids kegg 0.296 NA no no no no no dn 20:3/18:0-PC+blood Prevotella -0.568589366 -0.535871396 0 acetate-producing serum_phospholipids Genus 0.296 0.287 no no no no no no 20:3/18:0-PC+blood Propionic acid+stool 0 0 -0.687218045 yes serum_phospholipids stool_scfa 0.296 0.0436 no no no dn no up 20:3/18:0-PC+blood Relaxin signaling pathway -0.468421053 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Shigellosis -0.561403509 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Systemic lupus erythematosus 0.552631579 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Thermogenesis -0.505263158 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood total_stool_scfa+stool 0 0 -0.517293233 serum_phospholipids stool_scfa 0.296 0.0534 no no no dn no up 20:3/18:0-PC+blood Transcriptional misregulation in cancer 0 0 -0.475384615 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PC+blood Tuberculosis 0.526315789 0 0 serum_phospholipids kegg 0.296 NA no no no no no dn 20:3/18:0-PC+blood Ubiquitin mediated proteolysis -0.585964912 0 0 serum_phospholipids kegg 0.296 NA no no no no no no 20:3/18:0-PI+blood 16:0/18:0-PC+blood 0 0.524509804 0 serum_phospholipids serum_phospholipids 0.289 0.521 no no no no no no 20:3/18:0-PI+blood 16:0/18:0-PS+blood 0 0.629901961 0.483076923 serum_phospholipids serum_phospholipids 0.289 0.377 no no no no no no 20:3/18:0-PI+blood 16:0/20:5-PG+blood 0.621052632 0 0.484444444 serum_phospholipids serum_phospholipids 0.289 0.00656 no no no no up no 20:3/18:0-PI+blood 16:1/16:1-PC+blood 0.55037594 0 0 serum_phospholipids serum_phospholipids 0.289 0.0177 no no no no no up 20:3/18:0-PI+blood 16:1/18:1-PG+blood 0.508270677 0 0.444102564 serum_phospholipids serum_phospholipids 0.289 3.21E-05 no no no no up up 20:3/18:0-PI+blood 16:1/18:2-PG+blood 0 0 0.455726496 serum_phospholipids serum_phospholipids 0.289 1.40E-08 no no no no up up 20:3/18:0-PI+blood 18:0/18:0-PS+blood 0 0.490196078 0.545299145 serum_phospholipids serum_phospholipids 0.289 0.00617 no no no no up no 20:3/18:0-PI+blood 18:0/18:1-PG+blood 0 0 0.600683761 serum_phospholipids serum_phospholipids 0.289 0.000842 no no no no up no 20:3/18:0-PI+blood 18:0/18:1-PI+blood 0.446616541 0 0 serum_phospholipids serum_phospholipids 0.289 0.599 no no no no no no 20:3/18:0-PI+blood 18:0/18:2-PI+blood 0 0.566176471 0.505641026 serum_phospholipids serum_phospholipids 0.289 0.179 no no no no no no 20:3/18:0-PI+blood 18:0/20:3-PI+blood 0.655639098 0 0.502905983 serum_phospholipids serum_phospholipids 0.289 0.377 no no no no no no 20:3/18:0-PI+blood 18:0/20:4-PC+blood 0.526315789 0 0 serum_phospholipids serum_phospholipids 0.289 0.454 no no no no no no 20:3/18:0-PI+blood 18:0/20:4-PI+blood 0.977443609 0.975490196 0.987008547 serum_phospholipids serum_phospholipids 0.289 0.167 no no no no no no 20:3/18:0-PI+blood 18:0/22:6-PA+blood 0 0.610294118 0 serum_phospholipids serum_phospholipids 0.289 0.22 no no no no no no 20:3/18:0-PI+blood 18:1-LPC+blood 0.511278195 0 0 serum_phospholipids serum_phospholipids 0.289 0.179 no no no no no no 20:3/18:0-PI+blood 18:1-LPE+blood 0 0 -0.477606838 serum_phospholipids serum_phospholipids 0.289 0.117 no no no no no no 20:3/18:0-PI+blood 18:1/18:0-PI+blood 0.454135338 0 0 serum_phospholipids serum_phospholipids 0.289 0.0931 no no no no no up 20:3/18:0-PI+blood 18:1/18:0-PS+blood 0 0.68627451 0.491965812 serum_phospholipids serum_phospholipids 0.289 0.193 no no no no no no 20:3/18:0-PI+blood 18:1/18:1-PI+blood 0.496240602 0 0 serum_phospholipids serum_phospholipids 0.289 0.111 no no no dn no no 20:3/18:0-PI+blood 18:1/20:4-PC+blood 0.535338346 0 0 serum_phospholipids serum_phospholipids 0.289 0.582 no no no no no no 20:3/18:0-PI+blood 18:1+blood 0.496240602 0 0 yes serum_phospholipids serum_fattyacid 0.289 0.00202 no no no up no dn 20:3/18:0-PI+blood 18:2-LPC+blood 0 0 -0.498119658 serum_phospholipids serum_phospholipids 0.289 0.00743 no no no dn no up 20:3/18:0-PI+blood 18:2/18:2-PC+blood 0 0 -0.411282051 serum_phospholipids serum_phospholipids 0.289 1.98E-05 no no no dn up up 20:3/18:0-PI+blood 18:2/18:2-PS+blood 0 0 0.443418803 serum_phospholipids serum_phospholipids 0.289 0.00674 no no no up up no 20:3/18:0-PI+blood 18:3-LPC+blood -0.747368421 0 -0.409230769 serum_phospholipids serum_phospholipids 0.289 0.147 no no no no no no 20:3/18:0-PI+blood 20:0/20:5-PC+blood 0.729323308 0 0 serum_phospholipids serum_phospholipids 0.289 0.882 no no no no no no 20:3/18:0-PI+blood 20:1/20:4-PE+blood 0.551879699 0 0.447521368 serum_phospholipids serum_phospholipids 0.289 0.0042 no no no up up no 20:3/18:0-PI+blood 20:2-LPC+blood 0.448120301 0 0 serum_phospholipids serum_phospholipids 0.289 0.119 no no no no no up 20:3/18:0-PI+blood 20:2/18:3-PE+blood 0 0.639705882 0 serum_phospholipids serum_phospholipids 0.289 0.0391 no no no up up no 20:3n6+blood 11-HETE+blood 0 0.673953059 0 serum_fattyacid serum_ARA 0.0884 0.464 up no no no no no 20:3n6+blood 14:0-LPC+blood 0.601503759 0 0.582905983 serum_fattyacid serum_phospholipids 0.0884 0.00689 up no no up up no 20:3n6+blood 14:0/16:0-PC+blood 0 0.595588235 0.563760684 serum_fattyacid serum_phospholipids 0.0884 0.0358 up no no no up no 20:3n6+blood 14:0/18:0-PC+blood 0 0.825980392 0.599316239 serum_fattyacid serum_phospholipids 0.0884 0.00289 up no no up up no 20:3n6+blood 14:0/18:2-PC+blood 0 0 0.433846154 serum_fattyacid serum_phospholipids 0.0884 0.102 up no no no up no 20:3n6+blood 14:0+blood 0.542857143 0 0.496752137 yes serum_fattyacid serum_fattyacid 0.0884 0.00572 up no no up no dn 20:3n6+blood 14:1/18:2-PG+blood 0 0 0.485128205 serum_fattyacid serum_phospholipids 0.0884 0.00259 up no no no up up 20:3n6+blood 16:0-LPE+blood 0 0 0.446153846 serum_fattyacid serum_phospholipids 0.0884 0.0711 up no no up up no 20:3n6+blood 16:0/16:0-PC+blood -0.488721805 0 0 serum_fattyacid serum_phospholipids 0.0884 0.00079 up no no no up up 20:3n6+blood 16:0/16:0-PI+blood 0 0.522058824 0.44957265 serum_fattyacid serum_phospholipids 0.0884 0.358 up no no no no no 20:3n6+blood 16:0/16:1-PC+blood 0 0.835784314 0.617777778 serum_fattyacid serum_phospholipids 0.0884 0.00283 up no no up up no 20:3n6+blood 16:0/16:1-PI+blood 0.491729323 0.781862745 0.595897436 serum_fattyacid serum_phospholipids 0.0884 0.262 up no no no no no 20:3n6+blood 16:0/18:1-PC+blood -0.476691729 0 0 serum_fattyacid serum_phospholipids 0.0884 6.15E-07 up no no up up up 20:3n6+blood 16:0/18:1-PE+blood 0 0.639705882 0 serum_fattyacid serum_phospholipids 0.0884 0.000107 up no no up up no 20:3n6+blood 16:0/18:2-PI+blood 0.521804511 0.534313725 0.494017094 serum_fattyacid serum_phospholipids 0.0884 0.269 up no no no no no 20:3n6+blood 16:0/18:3-PC+blood 0 0 0.418119658 serum_fattyacid serum_phospholipids 0.0884 0.00216 up no no no up up 20:3n6+blood 16:0/20:3-PC+blood 0 0.683823529 0.580854701 serum_fattyacid serum_phospholipids 0.0884 5.43E-06 up no no no up up 20:3n6+blood 16:0/20:4-PI+blood 0.490225564 0 0.537777778 serum_fattyacid serum_phospholipids 0.0884 0.558 up no no no no no 20:3n6+blood 16:0/22:6-PC+blood 0 -0.534313725 0 serum_fattyacid serum_phospholipids 0.0884 4.53E-05 up no no no up up 20:3n6+blood 16:0+blood 0 0 0.624615385 yes serum_fattyacid serum_fattyacid 0.0884 0.00876 up no no up no no 20:3n6+blood 16:1-LPC+blood 0 0 0.53025641 serum_fattyacid serum_phospholipids 0.0884 0.0241 up no no no up no 20:3n6+blood 16:1/18:1-PG+blood 0 0.642156863 0 serum_fattyacid serum_phospholipids 0.0884 3.21E-05 up no no no up up 20:3n6+blood 18:0/16:0-PC+blood -0.526315789 0 0 serum_fattyacid serum_phospholipids 0.0884 9.64E-07 up no no up up up 20:3n6+blood 18:0/18:0-PC+blood 0 0.571078431 0 serum_fattyacid serum_phospholipids 0.0884 0.426 up no no no no no 20:3n6+blood 18:0/18:1-PC+blood 0 0.566176471 0 serum_fattyacid serum_phospholipids 0.0884 0.393 up no no no no no 20:3n6+blood 18:0/18:1-PI+blood 0 0.659313725 0 serum_fattyacid serum_phospholipids 0.0884 0.599 up no no no no no 20:3n6+blood 18:0/20:2-PC+blood 0 0.588235294 0 serum_fattyacid serum_phospholipids 0.0884 0.733 up no no no no no 20:3n6+blood 18:0/20:3-PC+blood 0.54887218 0.828431373 0.802393162 serum_fattyacid serum_phospholipids 0.0884 0.0682 up no no no up no 20:3n6+blood 18:0/20:3-PI+blood 0 0.830882353 0.521367521 serum_fattyacid serum_phospholipids 0.0884 0.377 up no no no no no 20:3n6+blood 18:0/20:4-PC+blood 0 -0.553921569 0 serum_fattyacid serum_phospholipids 0.0884 0.454 up no no no no no 20:3n6+blood 18:0/20:5-PC+blood 0 -0.68627451 -0.409230769 serum_fattyacid serum_phospholipids 0.0884 0.17 up no no no no no 20:3n6+blood 18:0+blood 0.493233083 0 0 serum_fattyacid serum_fattyacid 0.0884 0.344 up no no no no no 20:3n6+blood 18:1/16:0-PI+blood 0 0.588235294 0 serum_fattyacid serum_phospholipids 0.0884 0.793 up no no no no no 20:3n6+blood 18:1/16:1-PE+blood 0 0.656862745 0 serum_fattyacid serum_phospholipids 0.0884 0.000184 up no no up up no 20:3n6+blood 18:1/18:0-PE+blood 0 0.514705882 0 serum_fattyacid serum_phospholipids 0.0884 1.39E-06 up no no up up no 20:3n6+blood 18:1/18:1-PC+blood 0 0.781862745 0.598632479 serum_fattyacid serum_phospholipids 0.0884 1.34E-05 up no no no up up 20:3n6+blood 18:1/18:1-PE+blood 0 0.512254902 0 serum_fattyacid serum_phospholipids 0.0884 1.03E-05 up no no up up no 20:3n6+blood 18:1/18:1-PG+blood 0 0.772058824 0 serum_fattyacid serum_phospholipids 0.0884 0.00352 up no no no up up 20:3n6+blood 18:1/18:2-PG+blood 0 0.620098039 0 serum_fattyacid serum_phospholipids 0.0884 5.58E-07 up no no no up up 20:3n6+blood 18:1/20:3-PC+blood 0 0.580882353 0.495384615 serum_fattyacid serum_phospholipids 0.0884 0.00872 up no no no up up 20:3n6+blood 18:1/20:4-PC+blood 0 -0.512254902 0 serum_fattyacid serum_phospholipids 0.0884 0.582 up no no no no no 20:3n6+blood 18:2-LPC+blood 0 0 -0.455042735 serum_fattyacid serum_phospholipids 0.0884 0.00743 up no no dn no up 20:3n6+blood 18:2/18:2-PS+blood 0 0.781862745 0 serum_fattyacid serum_phospholipids 0.0884 0.00674 up no no up up no 20:3n6+blood 18:3-LPC+blood 0 -0.700980392 0 serum_fattyacid serum_phospholipids 0.0884 0.147 up no no no no no 20:3n6+blood 18:3/18:2-PC+blood 0 0 -0.43042735 serum_fattyacid serum_phospholipids 0.0884 0.0394 up no no no no up 20:3n6+blood 18:3n3+blood 0 -0.68627451 0 serum_fattyacid serum_fattyacid 0.0884 0.291 up no no no no no 20:3n6+blood 18:3n6+blood 0.580451128 0 0 serum_fattyacid serum_fattyacid 0.0884 0.0463 up no no up no dn 20:3n6+blood 20:1-LPC+blood -0.517293233 0 0 serum_fattyacid serum_phospholipids 0.0884 0.217 up no no no no no 20:3n6+blood 20:2/18:0-PC+blood 0.541353383 0.816176471 0.816752137 serum_fattyacid serum_phospholipids 0.0884 0.0427 up no no no up no 20:3n6+blood 20:2/18:1-PE+blood 0 0.681372549 0.56034188 serum_fattyacid serum_phospholipids 0.0884 0.00208 up no no up up no 20:3n6+blood 20:3-LPC+blood 0.798496241 0.75245098 0.796239316 serum_fattyacid serum_phospholipids 0.0884 0.0292 up no no no up no 20:3n6+blood 20:3-LPE+blood 0 0.607843137 0.518632479 serum_fattyacid serum_phospholipids 0.0884 0.084 up no no no up no 20:3n6+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0.653846154 0 0 serum_fattyacid stool_cometabolism 0.0884 0.33 up no no no no no 20:3n6+blood Adipocytokine signaling pathway 0 0 0.506923077 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Arachidonic acid metabolism 0 0 0.434615385 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Arginine and proline metabolism 0 0 0.466153846 serum_fattyacid kegg 0.0884 NA up no no no up no 20:3n6+blood Biosynthesis of cofactors 0 0 0.444615385 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood CDCA+stool 0 0.654545455 0 serum_fattyacid stool_bileacids 0.0884 0.663 up no no no no no 20:3n6+blood Central carbon metabolism in cancer 0 0 -0.531538462 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Clostridium 0 0.533415183 0 serum_fattyacid Genus 0.0884 0.925 up no no no no no 20:3n6+blood Epstein-Barr virus infection 0 0.582352941 0 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Ferroptosis 0 0 0.475384615 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood FoxO signaling pathway 0 0 -0.688461538 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Gastric cancer 0 0 -0.41 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood GCDCA+stool 0 0.690909091 0 yes serum_fattyacid stool_bileacids 0.0884 0.0471 up no no no dn no 20:3n6+blood Glutathione metabolism 0 0 0.538461538 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood "Glycine, serine and threonine metabolism" 0 0 0.461538462 serum_fattyacid kegg 0.0884 NA up no no no up no 20:3n6+blood Human cytomegalovirus infection 0 0.5 0 serum_fattyacid kegg 0.0884 NA up no no no no dn 20:3n6+blood Human immunodeficiency virus 1 infection 0 0.535294118 0 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Human T-cell leukemia virus 1 infection 0 0.517647059 0 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Kaposi sarcoma-associated herpesvirus infection 0 0 0.582307692 serum_fattyacid kegg 0.0884 NA up no no no no dn 20:3n6+blood Longevity regulating pathway 0 0 0.403076923 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood MAPK signaling pathway 0 -0.602941176 0 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood nutriCA+stool 0 0.706451749 0 serum_fattyacid stool_bileacids 0.0884 0.481 up no no no no no 20:3n6+blood Oocyte meiosis 0 0 -0.471538462 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Phenylacetic acid+stool 0 -0.636363636 0 serum_fattyacid stool_cometabolism 0.0884 0.785 up no no no no no 20:3n6+blood Phosphatidylinositol signaling system 0 0 -0.419230769 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Platinum drug resistance 0 0 -0.428461538 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Porphyrin and chlorophyll metabolism 0 0 0.49 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Primary immunodeficiency 0 0 -0.556153846 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Progesterone-mediated oocyte maturation 0 0 -0.586153846 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Purine metabolism 0 0 0.426153846 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Roseburia 0 0.571428679 0 butyrate-producing serum_fattyacid Genus 0.0884 0.495 up no no no no no 20:3n6+blood Shigellosis 0 0 0.423076923 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Sphingolipid signaling pathway 0 0 -0.542307692 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Spinocerebellar ataxia 0 0 -0.428461538 serum_fattyacid kegg 0.0884 NA up no no no no no 20:3n6+blood Thyroid hormone synthesis 0 0 0.423076923 serum_fattyacid kegg 0.0884 NA up no no no no no 20:4-LPA+blood 16:0/22:6-PE+blood 0 -0.649509804 0 serum_phospholipids serum_phospholipids 0.398 0.000934 no no no up up no 20:4-LPA+blood 16:0+blood 0.502255639 0 0 yes serum_phospholipids serum_fattyacid 0.398 0.00876 no no no up no no 20:4-LPA+blood 16:1+blood 0 -0.573529412 -0.425641026 yes serum_phospholipids serum_fattyacid 0.398 0.0186 no no no no no dn 20:4-LPA+blood 18:0-LPA+blood 0.493233083 0.600490196 0 serum_phospholipids serum_phospholipids 0.398 0.0725 no no no no dn no 20:4-LPA+blood 18:1/20:4-PC+blood 0 0 0.437948718 serum_phospholipids serum_phospholipids 0.398 0.582 no no no no no no 20:4-LPA+blood 18:1/20:4-PE+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.398 0.0578 no no no up no no 20:4-LPA+blood 18:3/16:0-PE+blood 0 -0.62745098 0 serum_phospholipids serum_phospholipids 0.398 0.00149 no no no up up no 20:4-LPA+blood 20:0-LPC+blood -0.508270677 0 0 serum_phospholipids serum_phospholipids 0.398 0.199 no no no no no no 20:4-LPA+blood 20:0+blood -0.446616541 0 0 yes serum_phospholipids serum_fattyacid 0.398 0.000278 no no no dn no up 20:4-LPA+blood 20:1-LPA+blood 0 0.681372549 0.731965812 serum_phospholipids serum_phospholipids 0.398 0.0187 no no no dn dn no 20:4-LPA+blood 20:2/18:1-PE+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.398 0.00208 no no no up up no 20:4-LPA+blood B cell receptor signaling pathway 0 0.5 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Butyricimonas 0 -0.579045868 0 butyrate-producing serum_phospholipids Genus 0.398 0.17 no no no no no no 20:4-LPA+blood Cell cycle 0 -0.655882353 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Central carbon metabolism in cancer 0.61754386 0 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood cGMP-PKG signaling pathway 0 0.576470588 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Cytokine-cytokine receptor interaction 0 0.570588235 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Epithelial cell signaling in Helicobacter pylori infection 0 0.561764706 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Fc gamma R-mediated phagocytosis 0 0.544117647 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood FoxO signaling pathway 0.464912281 0 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Glutathione metabolism -0.464912281 0 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood IL-17 signaling pathway 0 0.591176471 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood JAK-STAT signaling pathway 0.531578947 0 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Kaposi sarcoma-associated herpesvirus infection -0.480701754 0 0 serum_phospholipids kegg 0.398 NA no no no no no dn 20:4-LPA+blood Lipid and atherosclerosis 0 0.626470588 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Longevity regulating pathway - multiple species 0.475438596 0 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood mRNA surveillance pathway 0 -0.655882353 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Olfactory transduction 0 0.564705882 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Oocyte meiosis 0 -0.526470588 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Pathogenic Escherichia coli infection 0 0.6 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Progesterone-mediated oocyte maturation 0.49122807 0 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Protein processing in endoplasmic reticulum 0 -0.635294118 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Ras signaling pathway 0 -0.638235294 0 yes serum_phospholipids kegg 0.398 NA no no no no up up 20:4-LPA+blood Rheumatoid arthritis 0 0.532352941 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Ribosome biogenesis in eukaryotes 0 -0.544117647 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood RNA degradation 0 -0.502941176 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Shigellosis -0.526315789 0 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Spinocerebellar ataxia 0 -0.608823529 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Toll-like receptor signaling pathway 0 0.505882353 0 yes serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Toxoplasmosis 0 0.535294118 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPA+blood Wnt signaling pathway 0 -0.541176471 0 serum_phospholipids kegg 0.398 NA no no no no no no 20:4-LPC+blood 11-HETE+blood 0 -0.539162447 0 serum_phospholipids serum_ARA 0.949 0.464 no no no no no no 20:4-LPC+blood 12-ketoDCA+blood 0 0 -0.476303222 serum_phospholipids serum_bileacids 0.949 0.517 no no no no no no 20:4-LPC+blood 14:0/18:0-PC+blood 0 -0.735294118 0 serum_phospholipids serum_phospholipids 0.949 0.00289 no no no up up no 20:4-LPC+blood 16:0/16:0-PI+blood 0 -0.553921569 0 serum_phospholipids serum_phospholipids 0.949 0.358 no no no no no no 20:4-LPC+blood 16:0/16:1-PC+blood 0 -0.767156863 0 serum_phospholipids serum_phospholipids 0.949 0.00283 no no no up up no 20:4-LPC+blood 16:0/16:1-PI+blood 0 -0.617647059 0 serum_phospholipids serum_phospholipids 0.949 0.262 no no no no no no 20:4-LPC+blood 16:0/18:1-PE+blood 0 -0.720588235 0 serum_phospholipids serum_phospholipids 0.949 0.000107 no no no up up no 20:4-LPC+blood 16:0/18:2-PI+blood 0 -0.68627451 0 serum_phospholipids serum_phospholipids 0.949 0.269 no no no no no no 20:4-LPC+blood 16:0/20:3-PC+blood 0 -0.490196078 0 serum_phospholipids serum_phospholipids 0.949 5.43E-06 no no no no up up 20:4-LPC+blood 16:0/20:4-PC+blood 0.630075188 0.605392157 0.435897436 serum_phospholipids serum_phospholipids 0.949 0.0262 no no no no up no 20:4-LPC+blood 16:0/20:4-PE+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.949 0.00139 no no no up up no 20:4-LPC+blood 16:0/20:5-PG+blood 0.682706767 0 0.716239316 serum_phospholipids serum_phospholipids 0.949 0.00656 no no no no up no 20:4-LPC+blood 16:0/22:6-PC+blood 0 0.536764706 0 serum_phospholipids serum_phospholipids 0.949 4.53E-05 no no no no up up 20:4-LPC+blood 16:1/18:1-PG+blood 0 -0.50245098 0 serum_phospholipids serum_phospholipids 0.949 3.21E-05 no no no no up up 20:4-LPC+blood 16:1+blood 0 0 -0.416752137 yes serum_phospholipids serum_fattyacid 0.949 0.0186 no no no no no dn 20:4-LPC+blood 18:0/18:0-PC+blood 0 -0.590686275 0 serum_phospholipids serum_phospholipids 0.949 0.426 no no no no no no 20:4-LPC+blood 18:0/18:0-PE+blood 0 -0.558823529 0 serum_phospholipids serum_phospholipids 0.949 0.00896 no no no up up no 20:4-LPC+blood 18:0/18:1-PC+blood 0 -0.575980392 0 serum_phospholipids serum_phospholipids 0.949 0.393 no no no no no no 20:4-LPC+blood 18:0/18:1-PE+blood 0 -0.583333333 0 serum_phospholipids serum_phospholipids 0.949 0.00716 no no no up up no 20:4-LPC+blood 18:0/18:1-PI+blood 0 -0.620098039 0 serum_phospholipids serum_phospholipids 0.949 0.599 no no no no no no 20:4-LPC+blood 18:0/20:2-PC+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.949 0.733 no no no no no no 20:4-LPC+blood 18:0/20:3-PC+blood 0 -0.703431373 0 serum_phospholipids serum_phospholipids 0.949 0.0682 no no no no up no 20:4-LPC+blood 18:0/20:3-PI+blood 0 -0.607843137 0 serum_phospholipids serum_phospholipids 0.949 0.377 no no no no no no 20:4-LPC+blood 18:0/20:4-PC+blood 0.679699248 0.691176471 0.531623932 serum_phospholipids serum_phospholipids 0.949 0.454 no no no no no no 20:4-LPC+blood 18:0/20:4-PI+blood 0.488721805 0 0 serum_phospholipids serum_phospholipids 0.949 0.167 no no no no no no 20:4-LPC+blood 18:0/20:5-PC+blood 0 0.81372549 0 serum_phospholipids serum_phospholipids 0.949 0.17 no no no no no no 20:4-LPC+blood 18:1/16:0-PE+blood 0 -0.590686275 0 serum_phospholipids serum_phospholipids 0.949 0.000182 no no no up up no 20:4-LPC+blood 18:1/16:0-PI+blood 0 -0.632352941 0 serum_phospholipids serum_phospholipids 0.949 0.793 no no no no no no 20:4-LPC+blood 18:1/16:1-PE+blood 0 -0.740196078 0 serum_phospholipids serum_phospholipids 0.949 0.000184 no no no up up no 20:4-LPC+blood 18:1/18:0-PE+blood 0 -0.742647059 0 serum_phospholipids serum_phospholipids 0.949 1.39E-06 no no no up up no 20:4-LPC+blood 18:1/18:1-PC+blood 0 -0.62254902 0 serum_phospholipids serum_phospholipids 0.949 1.34E-05 no no no no up up 20:4-LPC+blood 18:1/18:1-PE+blood 0 -0.742647059 0 serum_phospholipids serum_phospholipids 0.949 1.03E-05 no no no up up no 20:4-LPC+blood 18:1/18:1-PG+blood 0 -0.651960784 0 serum_phospholipids serum_phospholipids 0.949 0.00352 no no no no up up 20:4-LPC+blood 18:1/18:2-PE+blood 0 -0.68627451 0 serum_phospholipids serum_phospholipids 0.949 0.000293 no no no up up no 20:4-LPC+blood 18:1/18:2-PG+blood 0 -0.544117647 0.439316239 serum_phospholipids serum_phospholipids 0.949 5.58E-07 no no no no up up 20:4-LPC+blood 18:1/20:4-PC+blood 0.726315789 0.612745098 0.532307692 serum_phospholipids serum_phospholipids 0.949 0.582 no no no no no no 20:4-LPC+blood 18:1+blood 0 0 -0.401709402 yes serum_phospholipids serum_fattyacid 0.949 0.00202 no no no up no dn 20:4-LPC+blood 18:2/18:2-PS+blood 0 -0.710784314 0 serum_phospholipids serum_phospholipids 0.949 0.00674 no no no up up no 20:4-LPC+blood 18:2/20:4-PC+blood 0 0.534313725 0 serum_phospholipids serum_phospholipids 0.949 0.0145 no no no no no up 20:4-LPC+blood 18:2n6c+blood 0 0 -0.40034188 serum_phospholipids serum_fattyacid 0.949 0.15 no no no no no no 20:4-LPC+blood 20:0/20:5-PC+blood 0.577443609 0 0 serum_phospholipids serum_phospholipids 0.949 0.882 no no no no no no 20:4-LPC+blood 20:1/20:4-PE+blood 0.446616541 0 0 serum_phospholipids serum_phospholipids 0.949 0.0042 no no no up up no 20:4-LPC+blood 20:2/18:0-PC+blood 0 -0.696078431 0 serum_phospholipids serum_phospholipids 0.949 0.0427 no no no no up no 20:4-LPC+blood 20:2/18:1-PE+blood 0 -0.754901961 0 serum_phospholipids serum_phospholipids 0.949 0.00208 no no no up up no 20:4-LPC+blood 20:3-LPC+blood 0 -0.490196078 0 serum_phospholipids serum_phospholipids 0.949 0.0292 no no no no up no 20:4-LPC+blood 20:3-LPE+blood 0 0 0.418119658 serum_phospholipids serum_phospholipids 0.949 0.084 no no no no up no 20:4-LPC+blood 20:3/16:0-PC+blood 0.535338346 0.571078431 0 serum_phospholipids serum_phospholipids 0.949 0.00405 no no no no up up 20:4-LPC+blood 20:3/18:0-PI+blood 0.52481203 0 0 serum_phospholipids serum_phospholipids 0.949 0.289 no no no no no no 20:4-LPC+blood 20:3n6+blood 0 -0.81127451 0 serum_phospholipids serum_fattyacid 0.949 0.0884 no no no up no no 20:4-LPC+blood Asthma 0 0 -0.523076923 serum_phospholipids kegg 0.949 NA no no no no no no 20:4-LPC+blood Bifidobacterium 0.497931588 0 0 acetate-producing serum_phospholipids Genus 0.949 0.105 no no no no dn no 20:4-LPC+blood Clostridium 0 0 0.465525895 serum_phospholipids Genus 0.949 0.925 no no no no no no 20:4-LPC+blood Epstein-Barr virus infection 0 -0.544117647 0 serum_phospholipids kegg 0.949 NA no no no no no no 20:4-LPC+blood Hematopoietic cell lineage 0 0 -0.478461538 serum_phospholipids kegg 0.949 NA no no no no no no 20:4-LPC+blood Inflammatory bowel disease 0 0 -0.516923077 serum_phospholipids kegg 0.949 NA no no no no no no 20:4-LPC+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.5 0 serum_phospholipids kegg 0.949 NA no no no no no dn 20:4-LPC+blood Leishmaniasis 0 0 -0.467692308 serum_phospholipids kegg 0.949 NA no no no no no no 20:4-LPC+blood MAPK signaling pathway 0 0.626470588 0 serum_phospholipids kegg 0.949 NA no no no no no no 20:4-LPC+blood Ruminococcus 0 -0.488044236 0 serum_phospholipids Genus 0.949 0.0679 no no no no no dn 20:4-LPC+blood Ruminococcus 0 -0.482843137 0 acetate-producing serum_phospholipids Genus 0.949 0.335 no no no no no no 20:4-LPC+blood Systemic lupus erythematosus 0 0 -0.443076923 serum_phospholipids kegg 0.949 NA no no no no no no 20:4-LPC+blood TCA+stool 0 -0.727272727 0 serum_phospholipids stool_bileacids 0.949 0.458 no no no no no no 20:4-LPC+blood Th17 cell differentiation 0 0 -0.471538462 serum_phospholipids kegg 0.949 NA no no no no no no 20:4-LPC+blood Toxoplasmosis 0 0 -0.571538462 serum_phospholipids kegg 0.949 NA no no no no no no 20:4-LPE+blood 12-HEPE+blood 0 0 -0.429762271 serum_phospholipids serum_ARA 0.552 0.312 no no no no no no 20:4-LPE+blood "12,13-EPOME+blood" 0 -0.591250338 -0.403115237 serum_phospholipids serum_ARA 0.552 0.901 no no no no no no 20:4-LPE+blood 14:0-LPC+blood -0.457142857 0 0 serum_phospholipids serum_phospholipids 0.552 0.00689 no no no up up no 20:4-LPE+blood 14:1/18:2-PG+blood -0.470676692 0 0 serum_phospholipids serum_phospholipids 0.552 0.00259 no no no no up up 20:4-LPE+blood 15-HETE+blood 0 0 0.454436016 serum_phospholipids serum_ARA 0.552 0.819 no no no no no no 20:4-LPE+blood 16:0/16:0-PI+blood 0 -0.583333333 0 serum_phospholipids serum_phospholipids 0.552 0.358 no no no no no no 20:4-LPE+blood 16:0/18:1-PE+blood 0 -0.49754902 0 serum_phospholipids serum_phospholipids 0.552 0.000107 no no no up up no 20:4-LPE+blood 16:0/18:2-PI+blood -0.497744361 -0.700980392 0 serum_phospholipids serum_phospholipids 0.552 0.269 no no no no no no 20:4-LPE+blood 16:0/20:4-PC+blood 0 0.81372549 0.42017094 serum_phospholipids serum_phospholipids 0.552 0.0262 no no no no up no 20:4-LPE+blood 16:0/20:4-PI+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.552 0.558 no no no no no no 20:4-LPE+blood 16:0/20:5-PC+blood 0 0 -0.442735043 serum_phospholipids serum_phospholipids 0.552 0.628 no no no no no no 20:4-LPE+blood 16:0/20:5-PG+blood 0.593984962 0.590686275 0 serum_phospholipids serum_phospholipids 0.552 0.00656 no no no no up no 20:4-LPE+blood 16:0/22:6-PC+blood 0 0.56127451 0 serum_phospholipids serum_phospholipids 0.552 4.53E-05 no no no no up up 20:4-LPE+blood 16:0+blood 0 0.487745098 0 yes serum_phospholipids serum_fattyacid 0.552 0.00876 no no no up no no 20:4-LPE+blood 16:1+blood 0.473684211 0 0 yes serum_phospholipids serum_fattyacid 0.552 0.0186 no no no no no dn 20:4-LPE+blood 18:0-LPE+blood 0 0 0.404444444 serum_phospholipids serum_phospholipids 0.552 0.491 no no no no no no 20:4-LPE+blood 18:0/18:0-PE+blood 0 -0.735294118 0 serum_phospholipids serum_phospholipids 0.552 0.00896 no no no up up no 20:4-LPE+blood 18:0/18:1-PE+blood 0 -0.801470588 0 serum_phospholipids serum_phospholipids 0.552 0.00716 no no no up up no 20:4-LPE+blood 18:0/20:4-PC+blood 0 0.723039216 0 serum_phospholipids serum_phospholipids 0.552 0.454 no no no no no no 20:4-LPE+blood 18:0/20:4-PI+blood 0.497744361 0.529411765 0 serum_phospholipids serum_phospholipids 0.552 0.167 no no no no no no 20:4-LPE+blood 18:0/20:5-PC+blood 0 0.578431373 0 serum_phospholipids serum_phospholipids 0.552 0.17 no no no no no no 20:4-LPE+blood 18:0/22:6-PI+blood 0 0 -0.45025641 serum_phospholipids serum_phospholipids 0.552 0.425 no no no no no no 20:4-LPE+blood 18:1-LPC+blood 0 0.526960784 0 serum_phospholipids serum_phospholipids 0.552 0.179 no no no no no no 20:4-LPE+blood 18:1/16:0-PE+blood 0 -0.524509804 0 serum_phospholipids serum_phospholipids 0.552 0.000182 no no no up up no 20:4-LPE+blood 18:1/16:0-PI+blood 0 -0.512254902 0 serum_phospholipids serum_phospholipids 0.552 0.793 no no no no no no 20:4-LPE+blood 18:1/16:1-PE+blood 0 -0.517156863 0 serum_phospholipids serum_phospholipids 0.552 0.000184 no no no up up no 20:4-LPE+blood 18:1/18:0-PE+blood 0 -0.593137255 0 serum_phospholipids serum_phospholipids 0.552 1.39E-06 no no no up up no 20:4-LPE+blood 18:1/18:1-PE+blood 0 -0.556372549 0 serum_phospholipids serum_phospholipids 0.552 1.03E-05 no no no up up no 20:4-LPE+blood 18:1/18:2-PE+blood 0 -0.617647059 0 serum_phospholipids serum_phospholipids 0.552 0.000293 no no no up up no 20:4-LPE+blood 18:1/20:4-PC+blood 0.648120301 0.605392157 0 serum_phospholipids serum_phospholipids 0.552 0.582 no no no no no no 20:4-LPE+blood 18:2/20:4-PC+blood 0 0.629901961 0 serum_phospholipids serum_phospholipids 0.552 0.0145 no no no no no up 20:4-LPE+blood 18:3/16:0-PE+blood 0 -0.607843137 0 serum_phospholipids serum_phospholipids 0.552 0.00149 no no no up up no 20:4-LPE+blood 20:0/20:5-PC+blood 0.542857143 0 0 serum_phospholipids serum_phospholipids 0.552 0.882 no no no no no no 20:4-LPE+blood 20:0+blood 0 0.580882353 0 yes serum_phospholipids serum_fattyacid 0.552 0.000278 no no no dn no up 20:4-LPE+blood 20:1-LPC+blood 0 0.514705882 0 serum_phospholipids serum_phospholipids 0.552 0.217 no no no no no no 20:4-LPE+blood 20:1-LPE+blood 0 0.703431373 0 serum_phospholipids serum_phospholipids 0.552 0.465 no no no no no no 20:4-LPE+blood 20:1/20:4-PE+blood 0.512781955 0 0 serum_phospholipids serum_phospholipids 0.552 0.0042 no no no up up no 20:4-LPE+blood 20:2-LPE+blood 0.57593985 0 0 serum_phospholipids serum_phospholipids 0.552 0.177 no no no no no no 20:4-LPE+blood 20:2/18:1-PE+blood 0 -0.575980392 0 serum_phospholipids serum_phospholipids 0.552 0.00208 no no no up up no 20:4-LPE+blood 20:2/18:3-PE+blood 0.6 0 0 serum_phospholipids serum_phospholipids 0.552 0.0391 no no no up up no 20:4-LPE+blood 20:3-LPE+blood 0 0 0.511111111 serum_phospholipids serum_phospholipids 0.552 0.084 no no no no up no 20:4-LPE+blood 20:3/16:0-PC+blood 0 0.784313725 0 serum_phospholipids serum_phospholipids 0.552 0.00405 no no no no up up 20:4-LPE+blood 20:3/18:0-PI+blood 0.502255639 0 0 serum_phospholipids serum_phospholipids 0.552 0.289 no no no no no no 20:4-LPE+blood 20:4-LPA+blood 0.463157895 0 0 serum_phospholipids serum_phospholipids 0.552 0.398 no no no no no no 20:4-LPE+blood 20:4-LPC+blood 0.709774436 0.49754902 0.498803419 serum_phospholipids serum_phospholipids 0.552 0.949 no no no no no no 20:4/16:0-PE+blood 16:0-LPC+blood 0 0 0.456410256 serum_phospholipids serum_phospholipids 0.00529 0.00456 no up up up up no 20:4/16:0-PE+blood 16:0/18:1-PC+blood -0.654135338 0 -0.422222222 serum_phospholipids serum_phospholipids 0.00529 6.15E-07 no up up up up up 20:4/16:0-PE+blood 16:0/18:1-PE+blood 0.598496241 0 0 serum_phospholipids serum_phospholipids 0.00529 0.000107 no up up up up no 20:4/16:0-PE+blood 16:0/18:2-PC+blood -0.6 0 0 serum_phospholipids serum_phospholipids 0.00529 3.24E-06 no up up no up up 20:4/16:0-PE+blood 16:0/18:2-PI+blood 0 0.482843137 0 serum_phospholipids serum_phospholipids 0.00529 0.269 no up up no no no 20:4/16:0-PE+blood 16:0/20:4-PC+blood -0.726315789 -0.575980392 0 serum_phospholipids serum_phospholipids 0.00529 0.0262 no up up no up no 20:4/16:0-PE+blood 16:0/20:5-PG+blood 0 0 -0.42974359 serum_phospholipids serum_phospholipids 0.00529 0.00656 no up up no up no 20:4/16:0-PE+blood 16:0/22:6-PC+blood 0 -0.566176471 0 serum_phospholipids serum_phospholipids 0.00529 4.53E-05 no up up no up up 20:4/16:0-PE+blood 16:0/22:6-PE+blood 0.454135338 0 0 serum_phospholipids serum_phospholipids 0.00529 0.000934 no up up up up no 20:4/16:0-PE+blood 16:1/16:0-PC+blood -0.509774436 -0.583333333 0 serum_phospholipids serum_phospholipids 0.00529 0.0215 no up up no up up 20:4/16:0-PE+blood 16:1/16:1-PC+blood -0.469172932 0 0 serum_phospholipids serum_phospholipids 0.00529 0.0177 no up up no no up 20:4/16:0-PE+blood 18:0-LPE+blood 0.54887218 0 0.490598291 serum_phospholipids serum_phospholipids 0.00529 0.491 no up up no no no 20:4/16:0-PE+blood 18:0/16:0-PC+blood -0.64962406 0 -0.427008547 serum_phospholipids serum_phospholipids 0.00529 9.64E-07 no up up up up up 20:4/16:0-PE+blood 18:0/18:0-PE+blood 0.52481203 0.762254902 0.467350427 serum_phospholipids serum_phospholipids 0.00529 0.00896 no up up up up no 20:4/16:0-PE+blood 18:0/18:1-PE+blood 0.566917293 0.68872549 0.469401709 serum_phospholipids serum_phospholipids 0.00529 0.00716 no up up up up no 20:4/16:0-PE+blood 18:0/20:4-PC+blood -0.685714286 -0.647058824 -0.402393162 serum_phospholipids serum_phospholipids 0.00529 0.454 no up up no no no 20:4/16:0-PE+blood 18:0/20:5-PC+blood -0.503759398 -0.710784314 0 serum_phospholipids serum_phospholipids 0.00529 0.17 no up up no no no 20:4/16:0-PE+blood 18:0/22:6-PC+blood 0 -0.56127451 0 serum_phospholipids serum_phospholipids 0.00529 0.0775 no up up no no up 20:4/16:0-PE+blood 18:1-LPE+blood 0.627067669 0 0.407863248 serum_phospholipids serum_phospholipids 0.00529 0.117 no up up no no no 20:4/16:0-PE+blood 18:1/16:0-PC+blood -0.652631579 0 0 serum_phospholipids serum_phospholipids 0.00529 2.43E-05 no up up no up up 20:4/16:0-PE+blood 18:1/16:0-PE+blood 0.506766917 0.519607843 0 serum_phospholipids serum_phospholipids 0.00529 0.000182 no up up up up no 20:4/16:0-PE+blood 18:1/16:1-PE+blood 0.565413534 0 0 serum_phospholipids serum_phospholipids 0.00529 0.000184 no up up up up no 20:4/16:0-PE+blood 18:1/18:0-PE+blood 0.715789474 0.531862745 0 serum_phospholipids serum_phospholipids 0.00529 1.39E-06 no up up up up no 20:4/16:0-PE+blood 18:1/18:0-PI+blood 0 0.605392157 0 serum_phospholipids serum_phospholipids 0.00529 0.0931 no up up no no up 20:4/16:0-PE+blood 18:1/18:1-PE+blood 0.705263158 0.504901961 0 serum_phospholipids serum_phospholipids 0.00529 1.03E-05 no up up up up no 20:4/16:0-PE+blood 18:1/18:2-PE+blood 0.8 0.696078431 0.535726496 serum_phospholipids serum_phospholipids 0.00529 0.000293 no up up up up no 20:4/16:0-PE+blood 18:1/18:2-PI+blood 0 0 0.535042735 serum_phospholipids serum_phospholipids 0.00529 0.0164 no up up dn no up 20:4/16:0-PE+blood 18:1/20:4-PC+blood -0.57593985 -0.737745098 -0.573333333 serum_phospholipids serum_phospholipids 0.00529 0.582 no up up no no no 20:4/16:0-PE+blood 18:2-LPA+blood -0.505263158 0 0 serum_phospholipids serum_phospholipids 0.00529 0.00684 no up up dn no up 20:4/16:0-PE+blood 18:2-LPE+blood 0.478195489 0 0.436581197 serum_phospholipids serum_phospholipids 0.00529 0.112 no up up no no no 20:4/16:0-PE+blood 18:2/18:1-PC+blood 0 0.691176471 0.545299145 serum_phospholipids serum_phospholipids 0.00529 2.30E-05 no up up dn up up 20:4/16:0-PE+blood 18:2/18:2-PC+blood 0 0.700980392 0.545982906 serum_phospholipids serum_phospholipids 0.00529 1.98E-05 no up up dn up up 20:4/16:0-PE+blood 18:2/18:2-PS+blood 0 0.487745098 0 serum_phospholipids serum_phospholipids 0.00529 0.00674 no up up up up no 20:4/16:0-PE+blood 18:2/20:4-PC+blood -0.464661654 0 0 serum_phospholipids serum_phospholipids 0.00529 0.0145 no up up no no up 20:4/16:0-PE+blood 18:3/16:0-PE+blood 0.559398496 0.754901961 0 serum_phospholipids serum_phospholipids 0.00529 0.00149 no up up up up no 20:4/16:0-PE+blood 18:3/18:2-PC+blood 0 0 0.452991453 serum_phospholipids serum_phospholipids 0.00529 0.0394 no up up no no up 20:4/16:0-PE+blood 20:0-LPE+blood 0.464661654 0 0.572649573 serum_phospholipids serum_phospholipids 0.00529 0.0615 no up up no no up 20:4/16:0-PE+blood 20:0/20:5-PC+blood 0 -0.632352941 0 serum_phospholipids serum_phospholipids 0.00529 0.882 no up up no no no 20:4/16:0-PE+blood 20:0+blood 0 0 0.419487179 yes serum_phospholipids serum_fattyacid 0.00529 0.000278 no up up dn no up 20:4/16:0-PE+blood 20:1/20:4-PC+blood 0 -0.654411765 0 serum_phospholipids serum_phospholipids 0.00529 0.0419 no up up no no up 20:4/16:0-PE+blood 20:2/18:1-PE+blood 0.589473684 0 0 serum_phospholipids serum_phospholipids 0.00529 0.00208 no up up up up no 20:4/16:0-PE+blood 20:3/16:0-PC+blood -0.715789474 -0.524509804 0 serum_phospholipids serum_phospholipids 0.00529 0.00405 no up up no up up 20:4/16:0-PE+blood 20:4-LPC+blood -0.556390977 0 0 serum_phospholipids serum_phospholipids 0.00529 0.949 no up up no no no 20:4/16:0-PE+blood 20:4-LPE+blood 0 -0.512254902 0 serum_phospholipids serum_phospholipids 0.00529 0.552 no up up no no no 20:4/18:0-PE+blood 12-HEPE+blood -0.478947384 0 0 serum_phospholipids serum_ARA 0.000755 0.312 up up no no no no 20:4/18:0-PE+blood 12-ketoDCA+blood 0 -0.497270443 0 serum_phospholipids serum_bileacids 0.000755 0.517 up up no no no no 20:4/18:0-PE+blood 12-ketoDCA+stool 0 0 0.563909774 serum_phospholipids stool_bileacids 0.000755 0.505 up up no no no no 20:4/18:0-PE+blood 16:0/18:0-PS+blood 0.815037594 0.642156863 0.586324786 serum_phospholipids serum_phospholipids 0.000755 0.377 up up no no no no 20:4/18:0-PE+blood 16:0/18:1-PE+blood 0.560902256 0 0.711452991 serum_phospholipids serum_phospholipids 0.000755 0.000107 up up no up up no 20:4/18:0-PE+blood 16:0/20:4-PE+blood 0.780451128 0.605392157 0.889230769 serum_phospholipids serum_phospholipids 0.000755 0.00139 up up no up up no 20:4/18:0-PE+blood 16:0/22:6-PE+blood 0.855639098 0.840686275 0.865299145 serum_phospholipids serum_phospholipids 0.000755 0.000934 up up no up up no 20:4/18:0-PE+blood 16:1+blood 0 0.522058824 0 yes serum_phospholipids serum_fattyacid 0.000755 0.0186 up up no no no dn 20:4/18:0-PE+blood 18:0-LPA+blood 0.618045113 0 0 serum_phospholipids serum_phospholipids 0.000755 0.0725 up up no no dn no 20:4/18:0-PE+blood 18:0-LPE+blood 0.562406015 0 0.469401709 serum_phospholipids serum_phospholipids 0.000755 0.491 up up no no no no 20:4/18:0-PE+blood 18:0/18:0-PE+blood 0.488721805 0 0 serum_phospholipids serum_phospholipids 0.000755 0.00896 up up no up up no 20:4/18:0-PE+blood 18:0/18:0-PS+blood 0.739849624 0.529411765 0.597948718 serum_phospholipids serum_phospholipids 0.000755 0.00617 up up no no up no 20:4/18:0-PE+blood 18:0/18:1-PE+blood 0.508270677 0 0.403076923 serum_phospholipids serum_phospholipids 0.000755 0.00716 up up no up up no 20:4/18:0-PE+blood 18:0/18:1-PG+blood 0.578947368 0 0.493333333 serum_phospholipids serum_phospholipids 0.000755 0.000842 up up no no up no 20:4/18:0-PE+blood 18:0/18:2-PI+blood 0.455639098 0 0 serum_phospholipids serum_phospholipids 0.000755 0.179 up up no no no no 20:4/18:0-PE+blood 18:0/20:2-PC+blood 0 0 -0.431794872 serum_phospholipids serum_phospholipids 0.000755 0.733 up up no no no no 20:4/18:0-PE+blood 18:0/20:4-PI+blood 0 0 0.481025641 serum_phospholipids serum_phospholipids 0.000755 0.167 up up no no no no 20:4/18:0-PE+blood 18:0/22:6-PE+blood 0.682706767 0.759803922 0.718974359 serum_phospholipids serum_phospholipids 0.000755 0.00022 up up no up up no 20:4/18:0-PE+blood 18:1/16:0-PE+blood 0.612030075 0 0.688205128 serum_phospholipids serum_phospholipids 0.000755 0.000182 up up no up up no 20:4/18:0-PE+blood 18:1/16:1-PE+blood 0.545864662 0 0.727179487 serum_phospholipids serum_phospholipids 0.000755 0.000184 up up no up up no 20:4/18:0-PE+blood 18:1/18:0-PE+blood 0.715789474 0 0.718974359 serum_phospholipids serum_phospholipids 0.000755 1.39E-06 up up no up up no 20:4/18:0-PE+blood 18:1/18:0-PS+blood 0 0.514705882 0 serum_phospholipids serum_phospholipids 0.000755 0.193 up up no no no no 20:4/18:0-PE+blood 18:1/18:1-PC+blood -0.467669173 0 0 serum_phospholipids serum_phospholipids 0.000755 1.34E-05 up up no no up up 20:4/18:0-PE+blood 18:1/18:1-PE+blood 0.735338346 0.485294118 0.718974359 serum_phospholipids serum_phospholipids 0.000755 1.03E-05 up up no up up no 20:4/18:0-PE+blood 18:1/18:2-PE+blood 0.494736842 0 0.606153846 serum_phospholipids serum_phospholipids 0.000755 0.000293 up up no up up no 20:4/18:0-PE+blood 18:1/20:3-PC+blood -0.460150376 0 0 serum_phospholipids serum_phospholipids 0.000755 0.00872 up up no no up up 20:4/18:0-PE+blood 18:1/20:4-PE+blood 0.834586466 0.867647059 0.855042735 serum_phospholipids serum_phospholipids 0.000755 0.0578 up up no up no no 20:4/18:0-PE+blood 18:1/22:6-PE+blood 0.62406015 0.578431373 0.435213675 serum_phospholipids serum_phospholipids 0.000755 0.0047 up up no no up no 20:4/18:0-PE+blood 18:1+blood 0 0 0.415384615 yes serum_phospholipids serum_fattyacid 0.000755 0.00202 up up no up no dn 20:4/18:0-PE+blood 18:2-LPC+blood 0 0 -0.434529915 serum_phospholipids serum_phospholipids 0.000755 0.00743 up up no dn no up 20:4/18:0-PE+blood 18:2/18:2-PS+blood 0.604511278 0 0 serum_phospholipids serum_phospholipids 0.000755 0.00674 up up no up up no 20:4/18:0-PE+blood 18:3-LPC+blood 0 0 -0.571965812 serum_phospholipids serum_phospholipids 0.000755 0.147 up up no no no no 20:4/18:0-PE+blood 18:3/16:0-PE+blood 0.542857143 0 0 serum_phospholipids serum_phospholipids 0.000755 0.00149 up up no up up no 20:4/18:0-PE+blood 20:0/20:4-PE+blood 0.751879699 0 0.598632479 serum_phospholipids serum_phospholipids 0.000755 0.00128 up up no up up no 20:4/18:0-PE+blood 20:1/20:4-PE+blood 0.760902256 0.730392157 0.744273504 serum_phospholipids serum_phospholipids 0.000755 0.0042 up up no up up no 20:4/18:0-PE+blood 20:1+blood 0 0 -0.407863248 yes serum_phospholipids serum_fattyacid 0.000755 2.56E-05 up up no dn dn dn 20:4/18:0-PE+blood 20:2-LPC+blood 0 0 -0.429059829 serum_phospholipids serum_phospholipids 0.000755 0.119 up up no no no up 20:4/18:0-PE+blood 20:2/18:1-PE+blood 0.664661654 0 0.651965812 serum_phospholipids serum_phospholipids 0.000755 0.00208 up up no up up no 20:4/18:0-PE+blood 20:2/18:3-PE+blood 0.741353383 0.75 0.796239316 serum_phospholipids serum_phospholipids 0.000755 0.0391 up up no up up no 20:4/18:0-PE+blood 20:3/18:0-PI+blood 0 0 0.45982906 serum_phospholipids serum_phospholipids 0.000755 0.289 up up no no no no 20:4/18:0-PE+blood Alcoholism 0 0.620588235 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Aldosterone synthesis and secretion -0.456140351 0 0 serum_phospholipids kegg 0.000755 NA up up no no up up 20:4/18:0-PE+blood Axon guidance 0 0 0.534615385 serum_phospholipids kegg 0.000755 NA up up no no up up 20:4/18:0-PE+blood Calcium signaling pathway -0.471929825 0 0 serum_phospholipids kegg 0.000755 NA up up no no up up 20:4/18:0-PE+blood cGMP-PKG signaling pathway 0 0 0.640769231 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Cholinergic synapse 0 0.641176471 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Cytosolic DNA-sensing pathway 0 -0.573529412 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Epithelial cell signaling in Helicobacter pylori infection 0 0 0.421538462 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Fc gamma R-mediated phagocytosis 0.5 0 0.422307692 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Ferroptosis -0.494736842 0 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood GDCA+stool 0 -0.665149789 0 serum_phospholipids stool_bileacids 0.000755 0.656 up up no no no no 20:4/18:0-PE+blood Glioma 0 0 0.433846154 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood GnRH signaling pathway -0.533333333 0 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Hepatitis C 0 -0.605882353 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Intestinal immune network for IgA production -0.622807018 0 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Kaposi sarcoma-associated herpesvirus infection -0.687719298 0 0 serum_phospholipids kegg 0.000755 NA up up no no no dn 20:4/18:0-PE+blood L-Phenylalanine+stool 0.71978022 0 0 serum_phospholipids stool_cometabolism 0.000755 0.398 up up no no no no 20:4/18:0-PE+blood L-Tryptophan+stool 0.653846154 0 0 serum_phospholipids stool_cometabolism 0.000755 0.557 up up no no no no 20:4/18:0-PE+blood L-Tyrosine+stool 0.587912088 0 0 serum_phospholipids stool_cometabolism 0.000755 0.44 up up no no no no 20:4/18:0-PE+blood LCA+stool 0 0 0.493233083 serum_phospholipids stool_bileacids 0.000755 0.314 up up no no no no 20:4/18:0-PE+blood Lipid and atherosclerosis 0 0 0.476923077 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Longevity regulating pathway - multiple species 0.514035088 0 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood MAPK signaling pathway 0.468421053 0 0.417692308 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Measles 0 -0.576470588 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Mineral absorption -0.496491228 0 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Mitophagy - animal -0.505263158 0 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Necroptosis -0.505263158 0 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Olfactory transduction 0.531578947 0 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Osteoclast differentiation 0 0 0.468461538 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Pertussis 0 0 0.475384615 serum_phospholipids kegg 0.000755 NA up up no no no dn 20:4/18:0-PE+blood PPAR signaling pathway 0 0 0.737692308 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Prevotella 0 0.520633347 0 acetate-producing serum_phospholipids Genus 0.000755 0.287 up up no no no no 20:4/18:0-PE+blood Primary immunodeficiency 0.521052632 0 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Relaxin signaling pathway -0.50877193 0 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Salivary secretion 0 0.664705882 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Salmonella infection 0.566666667 0 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Serotonergic synapse 0 0.5 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Shigellosis -0.498245614 0 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Slackia 0 0 -0.400945841 serum_phospholipids Genus 0.000755 0.94 up up no no no no 20:4/18:0-PE+blood T cell receptor signaling pathway 0 -0.561764706 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Th1 and Th2 cell differentiation 0 -0.526470588 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Th17 cell differentiation 0 -0.620588235 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Thyroid hormone synthesis -0.466666667 0 0 serum_phospholipids kegg 0.000755 NA up up no no no no 20:4/18:0-PE+blood Toll-like receptor signaling pathway 0 0 0.457692308 yes serum_phospholipids kegg 0.000755 NA up up no no no no 20:4n6+blood 14:0/18:0-PC+blood 0 -0.583333333 0 serum_fattyacid serum_phospholipids 0.133 0.00289 no no no up up no 20:4n6+blood 16:0-LPC+blood 0 0 -0.507692308 serum_fattyacid serum_phospholipids 0.133 0.00456 no no no up up no 20:4n6+blood 16:0/16:0-PI+blood 0 -0.659313725 0 serum_fattyacid serum_phospholipids 0.133 0.358 no no no no no no 20:4n6+blood 16:0/16:1-PC+blood 0 -0.605392157 0 serum_fattyacid serum_phospholipids 0.133 0.00283 no no no up up no 20:4n6+blood 16:0/16:1-PI+blood 0 -0.588235294 0 serum_fattyacid serum_phospholipids 0.133 0.262 no no no no no no 20:4n6+blood 16:0/18:1-PE+blood 0 -0.504901961 0 serum_fattyacid serum_phospholipids 0.133 0.000107 no no no up up no 20:4n6+blood 16:0/18:2-PI+blood -0.446616541 -0.649509804 0 serum_fattyacid serum_phospholipids 0.133 0.269 no no no no no no 20:4n6+blood 16:0/20:4-PC+blood 0.584962406 0.757352941 0.572649573 serum_fattyacid serum_phospholipids 0.133 0.0262 no no no no up no 20:4n6+blood 16:0/20:5-PC+blood 0 0.571078431 0 serum_fattyacid serum_phospholipids 0.133 0.628 no no no no no no 20:4n6+blood 16:0/20:5-PG+blood 0.705263158 0.482843137 0.512478632 serum_fattyacid serum_phospholipids 0.133 0.00656 no no no no up no 20:4n6+blood 16:0/22:6-PC+blood 0 0.644607843 0 serum_fattyacid serum_phospholipids 0.133 4.53E-05 no no no no up up 20:4n6+blood 16:0+blood 0 0.526960784 0 yes serum_fattyacid serum_fattyacid 0.133 0.00876 no no no up no no 20:4n6+blood 16:1/16:1-PC+blood 0.446616541 0 0 serum_fattyacid serum_phospholipids 0.133 0.0177 no no no no no up 20:4n6+blood 18:0/18:0-PE+blood 0 -0.612745098 0 serum_fattyacid serum_phospholipids 0.133 0.00896 no no no up up no 20:4n6+blood 18:0/18:1-PE+blood 0 -0.676470588 0 serum_fattyacid serum_phospholipids 0.133 0.00716 no no no up up no 20:4n6+blood 18:0/18:1-PI+blood 0 -0.605392157 0 serum_fattyacid serum_phospholipids 0.133 0.599 no no no no no no 20:4n6+blood 18:0/20:3-PC+blood 0 -0.529411765 0 serum_fattyacid serum_phospholipids 0.133 0.0682 no no no no up no 20:4n6+blood 18:0/20:4-PC+blood 0.678195489 0.776960784 0.684102564 serum_fattyacid serum_phospholipids 0.133 0.454 no no no no no no 20:4n6+blood 18:0/20:4-PI+blood 0.553383459 0 0 serum_fattyacid serum_phospholipids 0.133 0.167 no no no no no no 20:4n6+blood 18:0/20:5-PC+blood 0 0.786764706 0 serum_fattyacid serum_phospholipids 0.133 0.17 no no no no no no 20:4n6+blood 18:0+blood 0 0 0.575384615 serum_fattyacid serum_fattyacid 0.133 0.344 no no no no no no 20:4n6+blood 18:1/16:0-PE+blood 0 -0.504901961 0 serum_fattyacid serum_phospholipids 0.133 0.000182 no no no up up no 20:4n6+blood 18:1/16:0-PI+blood 0 -0.713235294 0 serum_fattyacid serum_phospholipids 0.133 0.793 no no no no no no 20:4n6+blood 18:1/16:1-PE+blood 0 -0.512254902 0 serum_fattyacid serum_phospholipids 0.133 0.000184 no no no up up no 20:4n6+blood 18:1/18:0-PE+blood 0 -0.571078431 0 serum_fattyacid serum_phospholipids 0.133 1.39E-06 no no no up up no 20:4n6+blood 18:1/18:0-PS+blood 0 0 0.422222222 serum_fattyacid serum_phospholipids 0.133 0.193 no no no no no no 20:4n6+blood 18:1/18:1-PE+blood 0 -0.519607843 0 serum_fattyacid serum_phospholipids 0.133 1.03E-05 no no no up up no 20:4n6+blood 18:1/18:1-PI+blood 0 -0.573529412 0 serum_fattyacid serum_phospholipids 0.133 0.111 no no no dn no no 20:4n6+blood 18:1/18:2-PE+blood 0 -0.634803922 0 serum_fattyacid serum_phospholipids 0.133 0.000293 no no no up up no 20:4n6+blood 18:1/20:4-PC+blood 0.780451128 0.605392157 0.665641026 serum_fattyacid serum_phospholipids 0.133 0.582 no no no no no no 20:4n6+blood 18:1/20:4-PI+blood 0 0 0.608205128 serum_fattyacid serum_phospholipids 0.133 0.192 no no no no no no 20:4n6+blood 18:2-LPC+blood 0 0 -0.403076923 serum_fattyacid serum_phospholipids 0.133 0.00743 no no no dn no up 20:4n6+blood 18:2-LPE+blood -0.505263158 0 -0.474188034 serum_fattyacid serum_phospholipids 0.133 0.112 no no no no no no 20:4n6+blood 18:2/20:4-PC+blood 0 0.536764706 0 serum_fattyacid serum_phospholipids 0.133 0.0145 no no no no no up 20:4n6+blood 18:3/16:0-PE+blood 0 -0.492647059 0 serum_fattyacid serum_phospholipids 0.133 0.00149 no no no up up no 20:4n6+blood 20:0-LPE+blood 0 -0.541666667 0 serum_fattyacid serum_phospholipids 0.133 0.0615 no no no no no up 20:4n6+blood 20:0/20:4-PE+blood 0.481203008 0 0 serum_fattyacid serum_phospholipids 0.133 0.00128 no no no up up no 20:4n6+blood 20:0/20:5-PC+blood 0.618045113 0 0 serum_fattyacid serum_phospholipids 0.133 0.882 no no no no no no 20:4n6+blood 20:1/20:4-PE+blood 0.604511278 0 0 serum_fattyacid serum_phospholipids 0.133 0.0042 no no no up up no 20:4n6+blood 20:2/18:0-PC+blood 0 -0.524509804 0 serum_fattyacid serum_phospholipids 0.133 0.0427 no no no no up no 20:4n6+blood 20:2/18:1-PE+blood 0 -0.590686275 0 serum_fattyacid serum_phospholipids 0.133 0.00208 no no no up up no 20:4n6+blood 20:2/18:3-PE+blood 0.49924812 0 0 serum_fattyacid serum_phospholipids 0.133 0.0391 no no no up up no 20:4n6+blood 20:3/16:0-PC+blood 0.511278195 0.776960784 0.530940171 serum_fattyacid serum_phospholipids 0.133 0.00405 no no no no up up 20:4n6+blood 20:3/18:0-PI+blood 0.57593985 0 0 serum_fattyacid serum_phospholipids 0.133 0.289 no no no no no no 20:4n6+blood 20:4-LPA+blood 0.532330827 0 0 serum_fattyacid serum_phospholipids 0.133 0.398 no no no no no no 20:4n6+blood 20:4-LPC+blood 0.780451128 0.693627451 0.658803419 serum_fattyacid serum_phospholipids 0.133 0.949 no no no no no no 20:4n6+blood 20:4-LPE+blood 0.72481203 0.725490196 0 serum_fattyacid serum_phospholipids 0.133 0.552 no no no no no no 20:4n6+blood 20:4/16:0-PE+blood 0 0 -0.442051282 serum_fattyacid serum_phospholipids 0.133 0.00529 no no no no up up 20:4n6+blood ACA+stool 0 0 -0.637329274 serum_fattyacid stool_bileacids 0.133 0.417 no no no no no no 20:4n6+blood Cholinergic synapse 0 0.629411765 0 serum_fattyacid kegg 0.133 NA no no no no no no 20:4n6+blood Clostridium -0.514479164 0 0 serum_fattyacid Genus 0.133 0.925 no no no no no no 20:4n6+blood GnRH signaling pathway -0.51754386 0 0 serum_fattyacid kegg 0.133 NA no no no no no no 20:4n6+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.561764706 0 serum_fattyacid kegg 0.133 NA no no no no no dn 20:4n6+blood MAPK signaling pathway 0 0.629411765 0 serum_fattyacid kegg 0.133 NA no no no no no no 20:4n6+blood Mitophagy - animal 0 -0.573529412 0 serum_fattyacid kegg 0.133 NA no no no no no no 20:4n6+blood Paraprevotella 0.518519556 0 0 serum_fattyacid Genus 0.133 0.118 no no no no no no 20:4n6+blood Parkinson disease 0 -0.555882353 0 serum_fattyacid kegg 0.133 NA no no no no no no 20:4n6+blood Pathways of neurodegeneration - multiple diseases 0 -0.558823529 0 serum_fattyacid kegg 0.133 NA no no no no no no 20:4n6+blood Porphyrin and chlorophyll metabolism 0 -0.591176471 0 serum_fattyacid kegg 0.133 NA no no no no no no 20:4n6+blood Renal cell carcinoma 0 -0.502941176 0 serum_fattyacid kegg 0.133 NA no no no no no no 20:4n6+blood Ruminococcus 0 -0.56372549 0 acetate-producing serum_fattyacid Genus 0.133 0.335 no no no no no no 20:4n6+blood Shigellosis 0 -0.658823529 0 serum_fattyacid kegg 0.133 NA no no no no no no 20:4n6+blood Ubiquitin mediated proteolysis 0 -0.567647059 0 serum_fattyacid kegg 0.133 NA no no no no no no 20:5-LPC+blood 14:0/18:0-PC+blood 0 -0.593137255 0 serum_phospholipids serum_phospholipids 0.558 0.00289 no no no up up no 20:5-LPC+blood 16:0/16:1-PC+blood 0 -0.590686275 0 serum_phospholipids serum_phospholipids 0.558 0.00283 no no no up up no 20:5-LPC+blood 16:0/16:1-PI+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.558 0.262 no no no no no no 20:5-LPC+blood 16:0/18:1-PE+blood 0 -0.49754902 0 serum_phospholipids serum_phospholipids 0.558 0.000107 no no no up up no 20:5-LPC+blood 16:0/20:3-PC+blood 0 -0.595588235 -0.50974359 serum_phospholipids serum_phospholipids 0.558 5.43E-06 no no no no up up 20:5-LPC+blood 16:0/20:5-PC+blood 0.945864662 0.772058824 0.785982906 serum_phospholipids serum_phospholipids 0.558 0.628 no no no no no no 20:5-LPC+blood 16:0/22:0-PE+blood 0 0.50245098 0 serum_phospholipids serum_phospholipids 0.558 0.00839 no no no dn no up 20:5-LPC+blood 16:0/22:6-PC+blood 0 0.492647059 0 serum_phospholipids serum_phospholipids 0.558 4.53E-05 no no no no up up 20:5-LPC+blood 16:1/18:1-PG+blood 0 -0.607843137 0 serum_phospholipids serum_phospholipids 0.558 3.21E-05 no no no no up up 20:5-LPC+blood 18:0-LPE+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.558 0.491 no no no no no no 20:5-LPC+blood 18:0/18:1-PI+blood 0 -0.573529412 0 serum_phospholipids serum_phospholipids 0.558 0.599 no no no no no no 20:5-LPC+blood 18:0/18:2-PI+blood -0.533834586 0 0 serum_phospholipids serum_phospholipids 0.558 0.179 no no no no no no 20:5-LPC+blood 18:0/20:2-PC+blood 0 -0.526960784 0 serum_phospholipids serum_phospholipids 0.558 0.733 no no no no no no 20:5-LPC+blood 18:0/20:3-PC+blood 0 -0.637254902 0 serum_phospholipids serum_phospholipids 0.558 0.0682 no no no no up no 20:5-LPC+blood 18:0/20:3-PI+blood -0.557894737 -0.661764706 0 serum_phospholipids serum_phospholipids 0.558 0.377 no no no no no no 20:5-LPC+blood 18:0/20:4-PC+blood 0 0.482843137 0 serum_phospholipids serum_phospholipids 0.558 0.454 no no no no no no 20:5-LPC+blood 18:0/20:4-PI+blood -0.460150376 0 0 serum_phospholipids serum_phospholipids 0.558 0.167 no no no no no no 20:5-LPC+blood 18:0/20:5-PC+blood 0 0.602941176 0 serum_phospholipids serum_phospholipids 0.558 0.17 no no no no no no 20:5-LPC+blood 18:0/22:6-PC+blood 0 0 0.437948718 serum_phospholipids serum_phospholipids 0.558 0.0775 no no no no no up 20:5-LPC+blood 18:1-LPC+blood -0.618045113 0 0 serum_phospholipids serum_phospholipids 0.558 0.179 no no no no no no 20:5-LPC+blood 18:1/16:0-PI+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.558 0.793 no no no no no no 20:5-LPC+blood 18:1/16:1-PE+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.558 0.000184 no no no up up no 20:5-LPC+blood 18:1/18:0-PI+blood -0.572932331 0 0 serum_phospholipids serum_phospholipids 0.558 0.0931 no no no no no up 20:5-LPC+blood 18:1/18:1-PC+blood 0 -0.703431373 -0.541196581 serum_phospholipids serum_phospholipids 0.558 1.34E-05 no no no no up up 20:5-LPC+blood 18:1/18:1-PG+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.558 0.00352 no no no no up up 20:5-LPC+blood 18:1/18:1-PI+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.558 0.111 no no no dn no no 20:5-LPC+blood 18:1/18:2-PI+blood -0.527819549 0 0 serum_phospholipids serum_phospholipids 0.558 0.0164 no no no dn no up 20:5-LPC+blood 18:1/20:3-PC+blood 0 -0.715686275 -0.502905983 serum_phospholipids serum_phospholipids 0.558 0.00872 no no no no up up 20:5-LPC+blood 18:2-LPE+blood 0 -0.50245098 0 serum_phospholipids serum_phospholipids 0.558 0.112 no no no no no no 20:5-LPC+blood 18:2/18:2-PS+blood 0 -0.5 0 serum_phospholipids serum_phospholipids 0.558 0.00674 no no no up up no 20:5-LPC+blood 18:3-LPC+blood 0 0.651960784 0.458461538 serum_phospholipids serum_phospholipids 0.558 0.147 no no no no no no 20:5-LPC+blood 18:3n3+blood 0 0.634803922 0 serum_phospholipids serum_fattyacid 0.558 0.291 no no no no no no 20:5-LPC+blood 20:0/20:4-PE+blood 0 0 -0.489230769 serum_phospholipids serum_phospholipids 0.558 0.00128 no no no up up no 20:5-LPC+blood 20:1/20:4-PE+blood -0.448120301 0 0 serum_phospholipids serum_phospholipids 0.558 0.0042 no no no up up no 20:5-LPC+blood 20:2-LPC+blood -0.613533835 0 0 serum_phospholipids serum_phospholipids 0.558 0.119 no no no no no up 20:5-LPC+blood 20:2/18:0-PC+blood 0 -0.629901961 0 serum_phospholipids serum_phospholipids 0.558 0.0427 no no no no up no 20:5-LPC+blood 20:2/18:1-PE+blood 0 -0.482843137 0 serum_phospholipids serum_phospholipids 0.558 0.00208 no no no up up no 20:5-LPC+blood 20:2+blood -0.593984962 -0.539215686 0 serum_phospholipids serum_fattyacid 0.558 0.478 no no no no no no 20:5-LPC+blood 20:3-LPC+blood 0 -0.661764706 0 serum_phospholipids serum_phospholipids 0.558 0.0292 no no no no up no 20:5-LPC+blood 20:3-LPE+blood 0 -0.720588235 0 serum_phospholipids serum_phospholipids 0.558 0.084 no no no no up no 20:5-LPC+blood 20:3n6+blood 0 -0.75 0 serum_phospholipids serum_fattyacid 0.558 0.0884 no no no up no no 20:5-LPC+blood 20:4-LPC+blood 0 0.727941176 0 serum_phospholipids serum_phospholipids 0.558 0.949 no no no no no no 20:5-LPC+blood 20:4n6+blood 0 0.649509804 0 serum_phospholipids serum_fattyacid 0.558 0.133 no no no no no no 20:5/18:0-PC+blood 14:0-LPC+blood 0 -0.56372549 0 serum_phospholipids serum_phospholipids 3.97E-06 0.00689 no up up up up no 20:5/18:0-PC+blood 14:0/18:0-PC+blood 0 -0.49754902 0 serum_phospholipids serum_phospholipids 3.97E-06 0.00289 no up up up up no 20:5/18:0-PC+blood 14:0/20:4-PC+blood 0 0 -0.428376068 serum_phospholipids serum_phospholipids 3.97E-06 0.486 no up up no no no 20:5/18:0-PC+blood 16:0/14:0-PC+blood 0 0 0.533675214 serum_phospholipids serum_phospholipids 3.97E-06 0.0206 no up up no up up 20:5/18:0-PC+blood 16:0/16:0-PC+blood 0.563909774 0 0 serum_phospholipids serum_phospholipids 3.97E-06 0.00079 no up up no up up 20:5/18:0-PC+blood 16:0/16:0-PI+blood 0 -0.68627451 0 serum_phospholipids serum_phospholipids 3.97E-06 0.358 no up up no no no 20:5/18:0-PC+blood 16:0/16:1-PI+blood 0 -0.568627451 0 serum_phospholipids serum_phospholipids 3.97E-06 0.262 no up up no no no 20:5/18:0-PC+blood 16:0/18:0-PC+blood 0.47518797 0 0.457094017 serum_phospholipids serum_phospholipids 3.97E-06 0.521 no up up no no no 20:5/18:0-PC+blood 16:0/18:1-PC+blood 0 0.68872549 0.487179487 serum_phospholipids serum_phospholipids 3.97E-06 6.15E-07 no up up up up up 20:5/18:0-PC+blood 16:0/18:2-PC+blood 0.615037594 0.556372549 0.766837607 serum_phospholipids serum_phospholipids 3.97E-06 3.24E-06 no up up no up up 20:5/18:0-PC+blood 16:0/18:2-PI+blood 0 -0.617647059 0 serum_phospholipids serum_phospholipids 3.97E-06 0.269 no up up no no no 20:5/18:0-PC+blood 16:0/20:3-PC+blood 0.54887218 0 0 serum_phospholipids serum_phospholipids 3.97E-06 5.43E-06 no up up no up up 20:5/18:0-PC+blood 16:0/20:4-PC+blood 0 0.745098039 0 serum_phospholipids serum_phospholipids 3.97E-06 0.0262 no up up no up no 20:5/18:0-PC+blood 16:0/20:4-PI+blood 0 -0.509803922 0 serum_phospholipids serum_phospholipids 3.97E-06 0.558 no up up no no no 20:5/18:0-PC+blood 16:0/22:0-PE+blood 0.738345865 0.598039216 0.602735043 serum_phospholipids serum_phospholipids 3.97E-06 0.00839 no up up dn no up 20:5/18:0-PC+blood 16:0/22:6-PC+blood 0.918796992 0.963235294 0.90974359 serum_phospholipids serum_phospholipids 3.97E-06 4.53E-05 no up up no up up 20:5/18:0-PC+blood 16:1/16:0-PC+blood 0.681203008 0.81372549 0.621880342 serum_phospholipids serum_phospholipids 3.97E-06 0.0215 no up up no up up 20:5/18:0-PC+blood 16:1/16:1-PC+blood 0.535338346 0.610294118 0.404444444 serum_phospholipids serum_phospholipids 3.97E-06 0.0177 no up up no no up 20:5/18:0-PC+blood 18:0/16:0-PC+blood 0.446616541 0.68872549 0.452991453 serum_phospholipids serum_phospholipids 3.97E-06 9.64E-07 no up up up up up 20:5/18:0-PC+blood 18:0/18:0-PE+blood 0 -0.568627451 0 serum_phospholipids serum_phospholipids 3.97E-06 0.00896 no up up up up no 20:5/18:0-PC+blood 18:0/18:1-PE+blood 0 -0.625 0 serum_phospholipids serum_phospholipids 3.97E-06 0.00716 no up up up up no 20:5/18:0-PC+blood 18:0/18:1-PG+blood 0 0 -0.632820513 serum_phospholipids serum_phospholipids 3.97E-06 0.000842 no up up no up no 20:5/18:0-PC+blood 18:0/18:2-PC+blood 0.696240602 0 0.797606838 serum_phospholipids serum_phospholipids 3.97E-06 1.74E-06 no up up no up up 20:5/18:0-PC+blood 18:0/20:4-PC+blood 0 0.825980392 0 serum_phospholipids serum_phospholipids 3.97E-06 0.454 no up up no no no 20:5/18:0-PC+blood 18:0/20:5-PC+blood 0.544360902 0.659313725 0 serum_phospholipids serum_phospholipids 3.97E-06 0.17 no up up no no no 20:5/18:0-PC+blood 18:0/22:6-PA+blood 0.454135338 0.529411765 0 serum_phospholipids serum_phospholipids 3.97E-06 0.22 no up up no no no 20:5/18:0-PC+blood 18:0/22:6-PC+blood 0.839097744 0.727941176 0.680683761 serum_phospholipids serum_phospholipids 3.97E-06 0.0775 no up up no no up 20:5/18:0-PC+blood 18:0/22:6-PI+blood 0.460150376 0.509803922 0 serum_phospholipids serum_phospholipids 3.97E-06 0.425 no up up no no no 20:5/18:0-PC+blood 18:1-LPE+blood -0.615037594 0 0 serum_phospholipids serum_phospholipids 3.97E-06 0.117 no up up no no no 20:5/18:0-PC+blood 18:1/16:0-PC+blood 0.603007519 0.568627451 0.761367521 serum_phospholipids serum_phospholipids 3.97E-06 2.43E-05 no up up no up up 20:5/18:0-PC+blood 18:1/16:0-PE+blood -0.636090226 -0.512254902 0 serum_phospholipids serum_phospholipids 3.97E-06 0.000182 no up up up up no 20:5/18:0-PC+blood 18:1/16:0-PI+blood 0 -0.637254902 0 serum_phospholipids serum_phospholipids 3.97E-06 0.793 no up up no no no 20:5/18:0-PC+blood 18:1/18:0-PC+blood 0.678195489 0 0.794871795 serum_phospholipids serum_phospholipids 3.97E-06 1.83E-06 no up up no up up 20:5/18:0-PC+blood 18:1/18:0-PE+blood 0 -0.575980392 0 serum_phospholipids serum_phospholipids 3.97E-06 1.39E-06 no up up up up no 20:5/18:0-PC+blood 18:1/18:2-PE+blood -0.470676692 -0.600490196 0 serum_phospholipids serum_phospholipids 3.97E-06 0.000293 no up up up up no 20:5/18:0-PC+blood 18:1/20:4-PC+blood 0 0.700980392 0 serum_phospholipids serum_phospholipids 3.97E-06 0.582 no up up no no no 20:5/18:0-PC+blood 18:1/22:6-PE+blood 0 0 0.56034188 serum_phospholipids serum_phospholipids 3.97E-06 0.0047 no up up no up no 20:5/18:0-PC+blood 18:2/16:0-PC+blood 0.606015038 0.534313725 0.548717949 serum_phospholipids serum_phospholipids 3.97E-06 8.67E-05 no up up no up up 20:5/18:0-PC+blood 18:2/20:4-PC+blood 0.464661654 0 0 serum_phospholipids serum_phospholipids 3.97E-06 0.0145 no up up no no up 20:5/18:0-PC+blood 18:3/16:0-PE+blood -0.487218045 -0.590686275 0 serum_phospholipids serum_phospholipids 3.97E-06 0.00149 no up up up up no 20:5/18:0-PC+blood 18:3n3+blood 0.532330827 0 0 serum_phospholipids serum_fattyacid 3.97E-06 0.291 no up up no no no 20:5/18:0-PC+blood 18:3n6+blood 0 0 -0.423589744 serum_phospholipids serum_fattyacid 3.97E-06 0.0463 no up up up no dn 20:5/18:0-PC+blood 20:0-LPE+blood -0.458646617 0 0 serum_phospholipids serum_phospholipids 3.97E-06 0.0615 no up up no no up 20:5/18:0-PC+blood 20:0/20:4-PE+blood -0.476691729 -0.74754902 -0.414700855 serum_phospholipids serum_phospholipids 3.97E-06 0.00128 no up up up up no 20:5/18:0-PC+blood 20:1/20:4-PC+blood 0.876691729 0.727941176 0.763418803 serum_phospholipids serum_phospholipids 3.97E-06 0.0419 no up up no no up 20:5/18:0-PC+blood 20:2-LPC+blood 0 0 0.515213675 serum_phospholipids serum_phospholipids 3.97E-06 0.119 no up up no no up 20:5/18:0-PC+blood 20:2/18:1-PE+blood 0 -0.522058824 0 serum_phospholipids serum_phospholipids 3.97E-06 0.00208 no up up up up no 20:5/18:0-PC+blood 20:2+blood 0 0 0.422222222 serum_phospholipids serum_fattyacid 3.97E-06 0.478 no up up no no no 20:5/18:0-PC+blood 20:3-LPE+blood -0.536842105 0 0 serum_phospholipids serum_phospholipids 3.97E-06 0.084 no up up no up no 20:5/18:0-PC+blood 20:3/16:0-PC+blood 0 0.762254902 0 serum_phospholipids serum_phospholipids 3.97E-06 0.00405 no up up no up up 20:5/18:0-PC+blood 20:3/18:0-PC+blood 0.532330827 0.806372549 0.575384615 serum_phospholipids serum_phospholipids 3.97E-06 0.296 no up up no no no 20:5/18:0-PC+blood 20:4-LPE+blood 0 0.566176471 0 serum_phospholipids serum_phospholipids 3.97E-06 0.552 no up up no no no 20:5/18:0-PC+blood 20:4/16:0-PE+blood 0 -0.509803922 0 serum_phospholipids serum_phospholipids 3.97E-06 0.00529 no up up no up up 20:5/18:0-PC+blood 20:4n6+blood 0 0.556372549 0 serum_phospholipids serum_fattyacid 3.97E-06 0.133 no up up no no no 20:5/18:0-PC+blood ACA+stool 0 0 0.453174211 serum_phospholipids stool_bileacids 3.97E-06 0.417 no up up no no no 20:5/18:0-PC+blood AGE-RAGE signaling pathway in diabetic complications 0.531578947 0 0 serum_phospholipids kegg 3.97E-06 NA no up up no no no 20:5/18:0-PC+blood Alzheimer disease 0 0 -0.506923077 serum_phospholipids kegg 3.97E-06 NA no up up no no no 20:5/18:0-PC+blood Amyotrophic lateral sclerosis 0 0 -0.446923077 serum_phospholipids kegg 3.97E-06 NA no up up no no no 20:5/18:0-PC+blood Blautia 0 0 -0.492970311 acetate-producing serum_phospholipids Genus 3.97E-06 1.36E-05 no up up up dn dn 20:5/18:0-PC+blood Butyricimonas 0.562948663 0 0.415797998 butyrate-producing serum_phospholipids Genus 3.97E-06 0.17 no up up no no no 20:5/18:0-PC+blood Cardiac muscle contraction 0 0 -0.507692308 serum_phospholipids kegg 3.97E-06 NA no up up no no up 20:5/18:0-PC+blood CDCA+stool 0 0 -0.470676692 serum_phospholipids stool_bileacids 3.97E-06 0.663 no up up no no no 20:5/18:0-PC+blood Choline metabolism in cancer 0 0 -0.47 serum_phospholipids kegg 3.97E-06 NA no up up no no no 20:5/18:0-PC+blood Cholinergic synapse 0 0 -0.489230769 serum_phospholipids kegg 3.97E-06 NA no up up no no no 20:5/18:0-PC+blood Clostridium 0.503196726 0 0 serum_phospholipids Genus 3.97E-06 0.925 no up up no no no 20:5/18:0-PC+blood Colorectal cancer 0 0 -0.484615385 serum_phospholipids kegg 3.97E-06 NA no up up no no no 20:5/18:0-PC+blood L-Phenylalanine+stool 0 0 0.502255639 serum_phospholipids stool_cometabolism 3.97E-06 0.398 no up up no no no 20:5/18:0-PC+blood L-Tyrosine+stool 0 0 0.490225564 serum_phospholipids stool_cometabolism 3.97E-06 0.44 no up up no no no 20:5/18:0-PC+blood Long-term potentiation 0 0 -0.407692308 serum_phospholipids kegg 3.97E-06 NA no up up no no up 20:5/18:0-PC+blood Necroptosis 0 0 0.414615385 serum_phospholipids kegg 3.97E-06 NA no up up no no no 20:5/18:0-PC+blood Parabacteroides 0 0.487745098 0 serum_phospholipids Genus 3.97E-06 4.19E-05 no up up no up up 20:5/18:0-PC+blood Peroxisome 0 0 0.463846154 serum_phospholipids kegg 3.97E-06 NA no up up no no no 20:5/18:0-PC+blood Prion disease 0 0 -0.44 serum_phospholipids kegg 3.97E-06 NA no up up no no no 20:5/18:0-PC+blood Retrograde endocannabinoid signaling 0 0 -0.514615385 serum_phospholipids kegg 3.97E-06 NA no up up no no up 20:5/18:0-PC+blood Ruminococcus 0 0 -0.430775904 serum_phospholipids Genus 3.97E-06 0.0679 no up up no no dn 20:5/18:0-PC+blood UDCA+stool 0 0 -0.527819549 serum_phospholipids stool_bileacids 3.97E-06 0.266 no up up no no no 20:5n3+blood "12,13-EPOME+blood" 0 0 0.435114704 serum_fattyacid serum_ARA 0.988 0.901 no no no no no no 20:5n3+blood 14:0/20:4-PC+blood 0.511278195 0 0 serum_fattyacid serum_phospholipids 0.988 0.486 no no no no no no 20:5n3+blood 16:0/16:0-PI+blood 0 -0.492647059 0 serum_fattyacid serum_phospholipids 0.988 0.358 no no no no no no 20:5n3+blood 16:0/18:0-PC+blood 0 0.509803922 0 serum_fattyacid serum_phospholipids 0.988 0.521 no no no no no no 20:5n3+blood 16:0/18:0-PS+blood 0 0.534313725 0 serum_fattyacid serum_phospholipids 0.988 0.377 no no no no no no 20:5n3+blood 16:0/20:3-PC+blood 0 0 -0.588376068 serum_fattyacid serum_phospholipids 0.988 5.43E-06 no no no no up up 20:5n3+blood 16:0/20:5-PC+blood 0.971428571 0.953431373 0.868034188 serum_fattyacid serum_phospholipids 0.988 0.628 no no no no no no 20:5n3+blood 16:0/22:0-PE+blood 0 0.666666667 0 serum_fattyacid serum_phospholipids 0.988 0.00839 no no no dn no up 20:5n3+blood 16:0/22:6-PC+blood 0 0.639705882 0 serum_fattyacid serum_phospholipids 0.988 4.53E-05 no no no no up up 20:5n3+blood 16:1/18:2-PG+blood -0.452631579 0 0 serum_fattyacid serum_phospholipids 0.988 1.40E-08 no no no no up up 20:5n3+blood 18:0/18:0-PS+blood 0 0.580882353 0 serum_fattyacid serum_phospholipids 0.988 0.00617 no no no no up no 20:5n3+blood 18:0/18:2-PI+blood -0.49924812 0 0 serum_fattyacid serum_phospholipids 0.988 0.179 no no no no no no 20:5n3+blood 18:0/20:3-PC+blood 0 0 -0.446153846 serum_fattyacid serum_phospholipids 0.988 0.0682 no no no no up no 20:5n3+blood 18:0/20:3-PI+blood -0.580451128 0 0 serum_fattyacid serum_phospholipids 0.988 0.377 no no no no no no 20:5n3+blood 18:0/20:4-PC+blood 0 0.568627451 0 serum_fattyacid serum_phospholipids 0.988 0.454 no no no no no no 20:5n3+blood 18:0/20:4-PI+blood -0.44962406 0 0 serum_fattyacid serum_phospholipids 0.988 0.167 no no no no no no 20:5n3+blood 18:0/20:5-PC+blood 0 0.517156863 0 serum_fattyacid serum_phospholipids 0.988 0.17 no no no no no no 20:5n3+blood 18:0/22:6-PA+blood 0 0.507352941 0 serum_fattyacid serum_phospholipids 0.988 0.22 no no no no no no 20:5n3+blood 18:0/22:6-PC+blood 0 0.62254902 0.444102564 serum_fattyacid serum_phospholipids 0.988 0.0775 no no no no no up 20:5n3+blood 18:0/22:6-PE+blood 0 0.578431373 0 serum_fattyacid serum_phospholipids 0.988 0.00022 no no no up up no 20:5n3+blood 18:0/22:6-PI+blood 0 0.507352941 0 serum_fattyacid serum_phospholipids 0.988 0.425 no no no no no no 20:5n3+blood 18:1-LPC+blood -0.652631579 0 0 serum_fattyacid serum_phospholipids 0.988 0.179 no no no no no no 20:5n3+blood 18:1-LPE+blood 0 -0.5 0 serum_fattyacid serum_phospholipids 0.988 0.117 no no no no no no 20:5n3+blood 18:1/16:0-PI+blood 0 -0.509803922 0 serum_fattyacid serum_phospholipids 0.988 0.793 no no no no no no 20:5n3+blood 18:1/18:0-PI+blood -0.488721805 0 0 serum_fattyacid serum_phospholipids 0.988 0.0931 no no no no no up 20:5n3+blood 18:1/18:0-PS+blood 0 0.575980392 0 serum_fattyacid serum_phospholipids 0.988 0.193 no no no no no no 20:5n3+blood 18:1/18:1-PC+blood 0 0 -0.615042735 serum_fattyacid serum_phospholipids 0.988 1.34E-05 no no no no up up 20:5n3+blood 18:1/18:2-PI+blood -0.565413534 0 0 serum_fattyacid serum_phospholipids 0.988 0.0164 no no no dn no up 20:5n3+blood 18:1/20:3-PC+blood 0 0 -0.628034188 serum_fattyacid serum_phospholipids 0.988 0.00872 no no no no up up 20:5n3+blood 18:2-LPA+blood 0 -0.634803922 0 serum_fattyacid serum_phospholipids 0.988 0.00684 no no no dn no up 20:5n3+blood 18:2-LPC+blood -0.463157895 0 0 serum_fattyacid serum_phospholipids 0.988 0.00743 no no no dn no up 20:5n3+blood 18:2-LPE+blood 0 -0.551470588 0 serum_fattyacid serum_phospholipids 0.988 0.112 no no no no no no 20:5n3+blood 20:0/20:4-PE+blood 0 0 -0.497435897 serum_fattyacid serum_phospholipids 0.988 0.00128 no no no up up no 20:5n3+blood 20:2-LPC+blood -0.672180451 0 0 serum_fattyacid serum_phospholipids 0.988 0.119 no no no no no up 20:5n3+blood 20:2/18:0-PC+blood 0 0 -0.417435897 serum_fattyacid serum_phospholipids 0.988 0.0427 no no no no up no 20:5n3+blood 20:2+blood -0.618045113 0 -0.420854701 serum_fattyacid serum_fattyacid 0.988 0.478 no no no no no no 20:5n3+blood 20:3-LPE+blood 0 -0.575980392 -0.415384615 serum_fattyacid serum_phospholipids 0.988 0.084 no no no no up no 20:5n3+blood 20:4-LPE+blood 0 0 -0.511794872 serum_fattyacid serum_phospholipids 0.988 0.552 no no no no no no 20:5n3+blood 20:4n6+blood 0 0.62254902 0 serum_fattyacid serum_fattyacid 0.988 0.133 no no no no no no 20:5n3+blood 20:5-LPC+blood 0.968421053 0.732843137 0.870769231 serum_fattyacid serum_phospholipids 0.988 0.558 no no no no no no 20:5n3+blood 20:5/18:0-PC+blood 0 0.539215686 0 serum_fattyacid serum_phospholipids 0.988 3.97E-06 no no no no up up 20:5n3+blood 4-hydroxybenzoic acid+stool -0.593406593 0 0 serum_fattyacid stool_cometabolism 0.988 0.0536 no no no no dn no 20:5n3+blood Amoebiasis 0 -0.538235294 0 serum_fattyacid kegg 0.988 NA no no no no no no 20:5n3+blood Bacteroides 0 0.578431373 0 LPS-producing serum_fattyacid Genus 0.988 0.000267 no no no dn dn up 20:5n3+blood Butyricimonas 0 0.546030095 0 butyrate-producing serum_fattyacid Genus 0.988 0.17 no no no no no no 20:5n3+blood cAMP signaling pathway 0 -0.611764706 0 yes serum_fattyacid kegg 0.988 NA no no no no up up 20:5n3+blood Cholinergic synapse 0 0.555882353 0 serum_fattyacid kegg 0.988 NA no no no no no no 20:5n3+blood Coprococcus 0.517293233 0 0 butyrate-producing serum_fattyacid Genus 0.988 0.612 no no no no no no 20:5n3+blood Ferroptosis 0 -0.652941176 0 serum_fattyacid kegg 0.988 NA no no no no no no 20:5n3+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.688235294 0 serum_fattyacid kegg 0.988 NA no no no no no dn 20:5n3+blood Long-term depression 0 -0.505882353 0 serum_fattyacid kegg 0.988 NA no no no no no no 20:5n3+blood Malaria 0 -0.570588235 0 serum_fattyacid kegg 0.988 NA no no no no no no 20:5n3+blood MAPK signaling pathway 0 0.605882353 0 serum_fattyacid kegg 0.988 NA no no no no no no 20:5n3+blood Necroptosis 0 -0.555882353 0 serum_fattyacid kegg 0.988 NA no no no no no no 20:5n3+blood Oscillospira 0.482706767 0 0 LPS-producing serum_fattyacid Genus 0.988 0.62 no no no no no no 20:5n3+blood Phosphatidylinositol signaling system 0 0.552941176 0 serum_fattyacid kegg 0.988 NA no no no no no no 20:5n3+blood Primary immunodeficiency 0 0.547058824 0 serum_fattyacid kegg 0.988 NA no no no no no no 20:5n3+blood Progesterone-mediated oocyte maturation 0 0.561764706 0 serum_fattyacid kegg 0.988 NA no no no no no no 20:5n3+blood Ras signaling pathway -0.466666667 0 0 yes serum_fattyacid kegg 0.988 NA no no no no up up 20:5n3+blood Renal cell carcinoma -0.471929825 0 0 serum_fattyacid kegg 0.988 NA no no no no no no 20:5n3+blood Ribosome biogenesis in eukaryotes 0 0.514705882 0 serum_fattyacid kegg 0.988 NA no no no no no no 20:5n3+blood Shigellosis 0 -0.576470588 0 serum_fattyacid kegg 0.988 NA no no no no no no 20:5n3+blood Viral protein interaction with cytokine and cytokine receptor 0 -0.573529412 0 serum_fattyacid kegg 0.988 NA no no no no no no 22:0/16:0-PE+blood 14:0-LPC+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.091 0.00689 no no up up up no 22:0/16:0-PE+blood 14:1/18:2-PG+blood 0 0 -0.426324786 serum_phospholipids serum_phospholipids 0.091 0.00259 no no up no up up 22:0/16:0-PE+blood 16:0-LPE+blood 0 -0.482843137 0 serum_phospholipids serum_phospholipids 0.091 0.0711 no no up up up no 22:0/16:0-PE+blood 16:0/14:0-PC+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 0.091 0.0206 no no up no up up 22:0/16:0-PE+blood 16:0/16:0-PC+blood 0.452631579 0.62745098 0 serum_phospholipids serum_phospholipids 0.091 0.00079 no no up no up up 22:0/16:0-PE+blood 16:0/16:0-PI+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.091 0.358 no no up no no no 22:0/16:0-PE+blood 16:0/18:0-PC+blood 0 0 0.589059829 serum_phospholipids serum_phospholipids 0.091 0.521 no no up no no no 22:0/16:0-PE+blood 16:0/18:1-PC+blood 0 0.830882353 0 serum_phospholipids serum_phospholipids 0.091 6.15E-07 no no up up up up 22:0/16:0-PE+blood 16:0/18:2-PC+blood 0 0.649509804 0 serum_phospholipids serum_phospholipids 0.091 3.24E-06 no no up no up up 22:0/16:0-PE+blood 16:0/20:4-PC+blood 0 0.566176471 0 serum_phospholipids serum_phospholipids 0.091 0.0262 no no up no up no 22:0/16:0-PE+blood 16:0/20:5-PC+blood 0.512781955 0.509803922 0 serum_phospholipids serum_phospholipids 0.091 0.628 no no up no no no 22:0/16:0-PE+blood 16:0/22:0-PE+blood 0.845112782 0.816176471 0.667692308 serum_phospholipids serum_phospholipids 0.091 0.00839 no no up dn no up 22:0/16:0-PE+blood 16:0/22:6-PC+blood 0.82406015 0.75245098 0.646495726 serum_phospholipids serum_phospholipids 0.091 4.53E-05 no no up no up up 22:0/16:0-PE+blood 16:1/16:0-PC+blood 0 0.703431373 0 serum_phospholipids serum_phospholipids 0.091 0.0215 no no up no up up 22:0/16:0-PE+blood 18:0-LPC+blood 0 -0.588235294 0 serum_phospholipids serum_phospholipids 0.091 0.554 no no up no no no 22:0/16:0-PE+blood 18:0-LPE+blood 0 -0.634803922 0 serum_phospholipids serum_phospholipids 0.091 0.491 no no up no no no 22:0/16:0-PE+blood 18:0/16:0-PC+blood 0 0.786764706 0 serum_phospholipids serum_phospholipids 0.091 9.64E-07 no no up up up up 22:0/16:0-PE+blood 18:0/18:0-PC+blood 0 0 0.543931624 serum_phospholipids serum_phospholipids 0.091 0.426 no no up no no no 22:0/16:0-PE+blood 18:0/18:1-PC+blood 0 0 0.499487179 serum_phospholipids serum_phospholipids 0.091 0.393 no no up no no no 22:0/16:0-PE+blood 18:0/18:1-PG+blood 0 -0.514705882 -0.515897436 serum_phospholipids serum_phospholipids 0.091 0.000842 no no up no up no 22:0/16:0-PE+blood 18:0/18:2-PC+blood 0 0.700980392 0.549401709 serum_phospholipids serum_phospholipids 0.091 1.74E-06 no no up no up up 22:0/16:0-PE+blood 18:0/18:2-PI+blood 0 0 -0.464615385 serum_phospholipids serum_phospholipids 0.091 0.179 no no up no no no 22:0/16:0-PE+blood 18:0/20:2-PC+blood 0 0 0.424273504 serum_phospholipids serum_phospholipids 0.091 0.733 no no up no no no 22:0/16:0-PE+blood 18:0/20:4-PC+blood 0 0.656862745 0 serum_phospholipids serum_phospholipids 0.091 0.454 no no up no no no 22:0/16:0-PE+blood 18:0/20:5-PC+blood 0.554887218 0.5 0 serum_phospholipids serum_phospholipids 0.091 0.17 no no up no no no 22:0/16:0-PE+blood 18:0/22:6-PA+blood 0 0.575980392 0 serum_phospholipids serum_phospholipids 0.091 0.22 no no up no no no 22:0/16:0-PE+blood 18:0/22:6-PC+blood 0.742857143 0.583333333 0 serum_phospholipids serum_phospholipids 0.091 0.0775 no no up no no up 22:0/16:0-PE+blood 18:0/22:6-PI+blood 0.502255639 0 0 serum_phospholipids serum_phospholipids 0.091 0.425 no no up no no no 22:0/16:0-PE+blood 18:1-LPE+blood -0.523308271 0 0 serum_phospholipids serum_phospholipids 0.091 0.117 no no up no no no 22:0/16:0-PE+blood 18:1/16:0-PC+blood 0 0.649509804 0 serum_phospholipids serum_phospholipids 0.091 2.43E-05 no no up no up up 22:0/16:0-PE+blood 18:1/18:0-PC+blood 0 0.693627451 0.548717949 serum_phospholipids serum_phospholipids 0.091 1.83E-06 no no up no up up 22:0/16:0-PE+blood 18:1/18:0-PI+blood 0 0 -0.438632479 serum_phospholipids serum_phospholipids 0.091 0.0931 no no up no no up 22:0/16:0-PE+blood 18:1/22:6-PE+blood 0 0 0.496068376 serum_phospholipids serum_phospholipids 0.091 0.0047 no no up no up no 22:0/16:0-PE+blood 18:2/16:0-PC+blood 0 0.585784314 0 serum_phospholipids serum_phospholipids 0.091 8.67E-05 no no up no up up 22:0/16:0-PE+blood 18:2/20:4-PC+blood 0.481203008 0 0 serum_phospholipids serum_phospholipids 0.091 0.0145 no no up no no up 22:0/16:0-PE+blood 18:3/16:0-PE+blood 0 -0.593137255 0 serum_phospholipids serum_phospholipids 0.091 0.00149 no no up up up no 22:0/16:0-PE+blood 18:3n6+blood 0 -0.495098039 0 serum_phospholipids serum_fattyacid 0.091 0.0463 no no up up no dn 22:0/16:0-PE+blood 20:0/20:4-PE+blood 0 -0.595588235 0 serum_phospholipids serum_phospholipids 0.091 0.00128 no no up up up no 22:0/16:0-PE+blood 20:1-LPC+blood 0 0 0.511794872 serum_phospholipids serum_phospholipids 0.091 0.217 no no up no no no 22:0/16:0-PE+blood 20:1/20:4-PC+blood 0.681203008 0.671568627 0.428376068 serum_phospholipids serum_phospholipids 0.091 0.0419 no no up no no up 22:0/16:0-PE+blood 20:1/20:4-PE+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.091 0.0042 no no up up up no 22:0/16:0-PE+blood 20:2-LPC+blood 0 0 0.440683761 serum_phospholipids serum_phospholipids 0.091 0.119 no no up no no up 22:0/16:0-PE+blood 20:2/18:1-PE+blood 0 -0.50245098 0 serum_phospholipids serum_phospholipids 0.091 0.00208 no no up up up no 22:0/16:0-PE+blood 20:3-LPE+blood -0.690225564 0 0 serum_phospholipids serum_phospholipids 0.091 0.084 no no up no up no 22:0/16:0-PE+blood 20:3/16:0-PC+blood 0 0.639705882 0 serum_phospholipids serum_phospholipids 0.091 0.00405 no no up no up up 22:0/16:0-PE+blood 20:3/18:0-PC+blood 0.481203008 0.62254902 0.680683761 serum_phospholipids serum_phospholipids 0.091 0.296 no no up no no no 22:0/16:0-PE+blood 20:3/18:0-PI+blood 0 0 -0.436581197 serum_phospholipids serum_phospholipids 0.091 0.289 no no up no no no 22:0/16:0-PE+blood 20:4n6+blood 0 0.549019608 0 serum_phospholipids serum_fattyacid 0.091 0.133 no no up no no no 22:0/16:0-PE+blood 20:5-LPC+blood 0.466165414 0 0 serum_phospholipids serum_phospholipids 0.091 0.558 no no up no no no 22:0/16:0-PE+blood 20:5/18:0-PC+blood 0.726315789 0.794117647 0.684786325 serum_phospholipids serum_phospholipids 0.091 3.97E-06 no no up no up up 22:0/16:0-PE+blood 20:5n3+blood 0.512781955 0.531862745 0 serum_phospholipids serum_fattyacid 0.091 0.988 no no up no no no 22:1-LPA+blood 14:1/18:2-PG+blood 0.473684211 0 0 serum_phospholipids serum_phospholipids 0.00373 0.00259 no up up no up up 22:1-LPA+blood 16:0/22:6-PE+blood 0 -0.629901961 0 serum_phospholipids serum_phospholipids 0.00373 0.000934 no up up up up no 22:1-LPA+blood 16:1/16:1-PC+blood 0 0 -0.414700855 serum_phospholipids serum_phospholipids 0.00373 0.0177 no up up no no up 22:1-LPA+blood 18:0-LPA+blood 0 0.715686275 0.431111111 serum_phospholipids serum_phospholipids 0.00373 0.0725 no up up no dn no 22:1-LPA+blood 18:0/22:6-PC+blood 0.493233083 0 0 serum_phospholipids serum_phospholipids 0.00373 0.0775 no up up no no up 22:1-LPA+blood 18:1-LPE+blood -0.488721805 -0.492647059 0.527521368 serum_phospholipids serum_phospholipids 0.00373 0.117 no up up no no no 22:1-LPA+blood 18:1/18:1-PI+blood -0.596992481 0 0 serum_phospholipids serum_phospholipids 0.00373 0.111 no up up dn no no 22:1-LPA+blood 18:1/20:4-PE+blood 0 -0.490196078 0 serum_phospholipids serum_phospholipids 0.00373 0.0578 no up up up no no 22:1-LPA+blood 18:2-LPA+blood 0 0.485294118 0.469401709 serum_phospholipids serum_phospholipids 0.00373 0.00684 no up up dn no up 22:1-LPA+blood 20:1-LPA+blood 0.494736842 0.818627451 0.570598291 serum_phospholipids serum_phospholipids 0.00373 0.0187 no up up dn dn no 22:1-LPA+blood 20:1-LPC+blood -0.603007519 0 0 serum_phospholipids serum_phospholipids 0.00373 0.217 no up up no no no 22:1-LPA+blood 20:1/20:4-PC+blood 0.494736842 0 0 serum_phospholipids serum_phospholipids 0.00373 0.0419 no up up no no up 22:1-LPA+blood 20:2/18:3-PE+blood 0 -0.56127451 0 serum_phospholipids serum_phospholipids 0.00373 0.0391 no up up up up no 22:1-LPA+blood 20:4-LPA+blood 0 0.825980392 0.564444444 serum_phospholipids serum_phospholipids 0.00373 0.398 no up up no no no 22:1-LPA+blood 20:4/18:0-PE+blood 0 -0.522058824 0 serum_phospholipids serum_phospholipids 0.00373 0.000755 no up up up up no 22:2-LPA+blood 16:0-LPE+blood -0.557894737 0 0 serum_phospholipids serum_phospholipids 0.0443 0.0711 dn no no up up no 22:2-LPA+blood 16:0/18:3-PC+blood 0.497744361 0 0 serum_phospholipids serum_phospholipids 0.0443 0.00216 dn no no no up up 22:2-LPA+blood 16:0/20:5-PC+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.0443 0.628 dn no no no no no 22:2-LPA+blood 16:1/18:1-PG+blood 0 0.551470588 0 serum_phospholipids serum_phospholipids 0.0443 3.21E-05 dn no no no up up 22:2-LPA+blood 18:0-LPA+blood 0 0.647058824 0.416752137 serum_phospholipids serum_phospholipids 0.0443 0.0725 dn no no no dn no 22:2-LPA+blood 18:0-LPE+blood -0.467669173 0 0 serum_phospholipids serum_phospholipids 0.0443 0.491 dn no no no no no 22:2-LPA+blood 18:0/18:2-PI+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.0443 0.179 dn no no no no no 22:2-LPA+blood 18:1-LPE+blood 0 0 0.540512821 serum_phospholipids serum_phospholipids 0.0443 0.117 dn no no no no no 22:2-LPA+blood 18:1/16:0-PI+blood 0 0.509803922 0 serum_phospholipids serum_phospholipids 0.0443 0.793 dn no no no no no 22:2-LPA+blood 18:2-LPA+blood 0 0.585784314 0.541880342 serum_phospholipids serum_phospholipids 0.0443 0.00684 dn no no dn no up 22:2-LPA+blood 2-methyl-butyric acid m-C4+blood -0.473684211 0 0 serum_phospholipids serum_scfa 0.0443 0.262 dn no no no no no 22:2-LPA+blood 20:1-LPA+blood 0.634586466 0.715686275 0.610940171 serum_phospholipids serum_phospholipids 0.0443 0.0187 dn no no dn dn no 22:2-LPA+blood 20:3-LPE+blood 0 0 0.408547009 serum_phospholipids serum_phospholipids 0.0443 0.084 dn no no no up no 22:2-LPA+blood 20:4-LPA+blood 0 0 0.44957265 serum_phospholipids serum_phospholipids 0.0443 0.398 dn no no no no no 22:2-LPA+blood 20:4-LPC+blood 0 -0.553921569 0 serum_phospholipids serum_phospholipids 0.0443 0.949 dn no no no no no 22:2-LPA+blood 20:4n6+blood 0 -0.544117647 0 serum_phospholipids serum_fattyacid 0.0443 0.133 dn no no no no no 22:2-LPA+blood 20:5-LPC+blood 0 -0.661764706 0 serum_phospholipids serum_phospholipids 0.0443 0.558 dn no no no no no 22:2-LPA+blood 20:5n3+blood 0 -0.578431373 -0.422222222 serum_phospholipids serum_fattyacid 0.0443 0.988 dn no no no no no 22:2-LPA+blood 22:1-LPA+blood 0 0.649509804 0.60957265 serum_phospholipids serum_phospholipids 0.0443 0.00373 dn no no no up up 22:6-LPC+blood 14:0-LPC+blood 0 -0.512254902 0 serum_phospholipids serum_phospholipids 0.127 0.00689 no no up up up no 22:6-LPC+blood 14:0/18:0-PC+blood 0 -0.620098039 0 serum_phospholipids serum_phospholipids 0.127 0.00289 no no up up up no 22:6-LPC+blood 14:0+blood 0.658646617 0 0 yes serum_phospholipids serum_fattyacid 0.127 0.00572 no no up up no dn 22:6-LPC+blood 16:0-LPC+blood 0.490225564 0 0 serum_phospholipids serum_phospholipids 0.127 0.00456 no no up up up no 22:6-LPC+blood 16:0/14:0-PC+blood -0.445112782 0 0 serum_phospholipids serum_phospholipids 0.127 0.0206 no no up no up up 22:6-LPC+blood 16:0/16:0-PI+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.127 0.358 no no up no no no 22:6-LPC+blood 16:0/16:1-PC+blood -0.44962406 -0.590686275 0 serum_phospholipids serum_phospholipids 0.127 0.00283 no no up up up no 22:6-LPC+blood 16:0/16:1-PI+blood 0 -0.558823529 0 serum_phospholipids serum_phospholipids 0.127 0.262 no no up no no no 22:6-LPC+blood 16:0/18:2-PI+blood 0 -0.588235294 0 serum_phospholipids serum_phospholipids 0.127 0.269 no no up no no no 22:6-LPC+blood 16:0/20:4-PC+blood 0 0.529411765 0 serum_phospholipids serum_phospholipids 0.127 0.0262 no no up no up no 22:6-LPC+blood 16:0/20:5-PC+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 0.127 0.628 no no up no no no 22:6-LPC+blood 16:0/22:6-PC+blood 0 0.823529412 0.516581197 serum_phospholipids serum_phospholipids 0.127 4.53E-05 no no up no up up 22:6-LPC+blood 16:1/16:0-PC+blood 0 0.620098039 0 serum_phospholipids serum_phospholipids 0.127 0.0215 no no up no up up 22:6-LPC+blood 16:1+blood 0.464661654 0 0 yes serum_phospholipids serum_fattyacid 0.127 0.0186 no no up no no dn 22:6-LPC+blood 18:0/20:4-PC+blood 0 0.703431373 0 serum_phospholipids serum_phospholipids 0.127 0.454 no no up no no no 22:6-LPC+blood 18:0/20:5-PC+blood 0 0.764705882 0 serum_phospholipids serum_phospholipids 0.127 0.17 no no up no no no 22:6-LPC+blood 18:0/22:6-PC+blood 0.598496241 0.767156863 0.606153846 serum_phospholipids serum_phospholipids 0.127 0.0775 no no up no no up 22:6-LPC+blood 18:0/22:6-PI+blood 0.636090226 0.529411765 0.548034188 serum_phospholipids serum_phospholipids 0.127 0.425 no no up no no no 22:6-LPC+blood 18:1/16:0-PI+blood 0 -0.573529412 0 serum_phospholipids serum_phospholipids 0.127 0.793 no no up no no no 22:6-LPC+blood 18:1/18:0-PE+blood 0 -0.556372549 0 serum_phospholipids serum_phospholipids 0.127 1.39E-06 no no up up up no 22:6-LPC+blood 18:1/18:0-PI+blood 0 -0.492647059 0 serum_phospholipids serum_phospholipids 0.127 0.0931 no no up no no up 22:6-LPC+blood 18:1/18:1-PC+blood 0 -0.524509804 0 serum_phospholipids serum_phospholipids 0.127 1.34E-05 no no up no up up 22:6-LPC+blood 18:1/18:2-PE+blood 0 -0.585784314 0 serum_phospholipids serum_phospholipids 0.127 0.000293 no no up up up no 22:6-LPC+blood 18:1/20:3-PC+blood 0 -0.588235294 0 serum_phospholipids serum_phospholipids 0.127 0.00872 no no up no up up 22:6-LPC+blood 18:1/20:4-PC+blood 0 0.666666667 0 serum_phospholipids serum_phospholipids 0.127 0.582 no no up no no no 22:6-LPC+blood 18:2/18:2-PS+blood 0 -0.578431373 0 serum_phospholipids serum_phospholipids 0.127 0.00674 no no up up up no 22:6-LPC+blood 18:3n3+blood 0 0.522058824 0 serum_phospholipids serum_fattyacid 0.127 0.291 no no up no no no 22:6-LPC+blood 20:0/20:4-PE+blood -0.497744361 -0.691176471 -0.558290598 serum_phospholipids serum_phospholipids 0.127 0.00128 no no up up up no 22:6-LPC+blood 20:0/20:5-PC+blood 0 0.522058824 0 serum_phospholipids serum_phospholipids 0.127 0.882 no no up no no no 22:6-LPC+blood 20:1/20:4-PC+blood 0.539849624 0.598039216 0.555555556 serum_phospholipids serum_phospholipids 0.127 0.0419 no no up no no up 22:6-LPC+blood 20:1/20:4-PE+blood 0 0 -0.483760684 serum_phospholipids serum_phospholipids 0.127 0.0042 no no up up up no 22:6-LPC+blood 20:2/18:1-PE+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.127 0.00208 no no up up up no 22:6-LPC+blood 20:2/18:3-PE+blood 0 0 -0.437948718 serum_phospholipids serum_phospholipids 0.127 0.0391 no no up up up no 22:6-LPC+blood 20:2+blood 0 -0.573529412 0 serum_phospholipids serum_fattyacid 0.127 0.478 no no up no no no 22:6-LPC+blood 20:3-LPC+blood 0 -0.512254902 0 serum_phospholipids serum_phospholipids 0.127 0.0292 no no up no up no 22:6-LPC+blood 20:3-LPE+blood 0 -0.590686275 -0.427008547 serum_phospholipids serum_phospholipids 0.127 0.084 no no up no up no 22:6-LPC+blood 20:3/16:0-PC+blood 0 0.526960784 0 serum_phospholipids serum_phospholipids 0.127 0.00405 no no up no up up 22:6-LPC+blood 20:3n6+blood 0 -0.68872549 0 serum_phospholipids serum_fattyacid 0.127 0.0884 no no up up no no 22:6-LPC+blood 20:4-LPC+blood 0 0.678921569 0 serum_phospholipids serum_phospholipids 0.127 0.949 no no up no no no 22:6-LPC+blood 20:4-LPE+blood 0 0 -0.40034188 serum_phospholipids serum_phospholipids 0.127 0.552 no no up no no no 22:6-LPC+blood 20:4/18:0-PE+blood 0 0 -0.422905983 serum_phospholipids serum_phospholipids 0.127 0.000755 no no up up up no 22:6-LPC+blood 20:5-LPC+blood 0 0.649509804 0.734700855 serum_phospholipids serum_phospholipids 0.127 0.558 no no up no no no 22:6-LPC+blood 20:5/18:0-PC+blood 0 0.74754902 0.481709402 serum_phospholipids serum_phospholipids 0.127 3.97E-06 no no up no up up 22:6-LPC+blood 20:5n3+blood 0 0.519607843 0.524102564 serum_phospholipids serum_fattyacid 0.127 0.988 no no up no no no 22:6-LPC+blood 22:2-LPA+blood -0.464661654 0 0 serum_phospholipids serum_phospholipids 0.127 0.0443 no no up dn no no 22:6n3+blood 14:0/18:2-PC+blood 0.530827068 0 0 serum_fattyacid serum_phospholipids 0.792 0.102 no no no no up no 22:6n3+blood 14:0/20:4-PC+blood 0.466165414 0 0 serum_fattyacid serum_phospholipids 0.792 0.486 no no no no no no 22:6n3+blood 14:0+blood 0.603007519 0 0 yes serum_fattyacid serum_fattyacid 0.792 0.00572 no no no up no dn 22:6n3+blood 16:0/16:0-PI+blood 0.458646617 -0.529411765 0 serum_fattyacid serum_phospholipids 0.792 0.358 no no no no no no 22:6n3+blood 16:0/18:0-PS+blood 0 0.669117647 0 serum_fattyacid serum_phospholipids 0.792 0.377 no no no no no no 22:6n3+blood 16:0/20:4-PC+blood -0.485714286 0 0 serum_fattyacid serum_phospholipids 0.792 0.0262 no no no no up no 22:6n3+blood 16:0/20:4-PI+blood 0.484210526 0 0 serum_fattyacid serum_phospholipids 0.792 0.558 no no no no no no 22:6n3+blood 16:0/20:5-PC+blood 0.479699248 0.651960784 0 serum_fattyacid serum_phospholipids 0.792 0.628 no no no no no no 22:6n3+blood 16:0/20:5-PG+blood -0.467669173 0 0 serum_fattyacid serum_phospholipids 0.792 0.00656 no no no no up no 22:6n3+blood 16:0/22:0-PE+blood 0 0.625 0 serum_fattyacid serum_phospholipids 0.792 0.00839 no no no dn no up 22:6n3+blood 16:0/22:6-PC+blood 0.476691729 0.816176471 0.650598291 serum_fattyacid serum_phospholipids 0.792 4.53E-05 no no no no up up 22:6n3+blood 16:0+blood 0.509774436 0 0 yes serum_fattyacid serum_fattyacid 0.792 0.00876 no no no up no no 22:6n3+blood 16:1/16:0-PC+blood 0 0.607843137 0 serum_fattyacid serum_phospholipids 0.792 0.0215 no no no no up up 22:6n3+blood 18:0-LPE+blood 0.467669173 0 0 serum_fattyacid serum_phospholipids 0.792 0.491 no no no no no no 22:6n3+blood 18:0/18:0-PS+blood 0 0.568627451 0 serum_fattyacid serum_phospholipids 0.792 0.00617 no no no no up no 22:6n3+blood 18:0/20:3-PC+blood 0.488721805 0 0 serum_fattyacid serum_phospholipids 0.792 0.0682 no no no no up no 22:6n3+blood 18:0/20:4-PC+blood 0 0.681372549 0 serum_fattyacid serum_phospholipids 0.792 0.454 no no no no no no 22:6n3+blood 18:0/20:4-PI+blood 0 0.617647059 0 serum_fattyacid serum_phospholipids 0.792 0.167 no no no no no no 22:6n3+blood 18:0/20:5-PC+blood 0 0.654411765 0 serum_fattyacid serum_phospholipids 0.792 0.17 no no no no no no 22:6n3+blood 18:0/22:6-PA+blood 0 0.5 0.456410256 serum_fattyacid serum_phospholipids 0.792 0.22 no no no no no no 22:6n3+blood 18:0/22:6-PC+blood 0.657142857 0.845588235 0.648547009 serum_fattyacid serum_phospholipids 0.792 0.0775 no no no no no up 22:6n3+blood 18:0/22:6-PE+blood 0 0.725490196 0 serum_fattyacid serum_phospholipids 0.792 0.00022 no no no up up no 22:6n3+blood 18:0/22:6-PI+blood 0.766917293 0.818627451 0.650598291 serum_fattyacid serum_phospholipids 0.792 0.425 no no no no no no 22:6n3+blood 18:0+blood 0.478195489 0 0 serum_fattyacid serum_fattyacid 0.792 0.344 no no no no no no 22:6n3+blood 18:1-LPC+blood -0.476691729 0 0 serum_fattyacid serum_phospholipids 0.792 0.179 no no no no no no 22:6n3+blood 18:1-LPE+blood 0 -0.536764706 -0.422222222 serum_fattyacid serum_phospholipids 0.792 0.117 no no no no no no 22:6n3+blood 18:1/16:0-PI+blood 0 -0.5 0 serum_fattyacid serum_phospholipids 0.792 0.793 no no no no no no 22:6n3+blood 18:1/18:0-PS+blood 0 0.678921569 0.404444444 serum_fattyacid serum_phospholipids 0.792 0.193 no no no no no no 22:6n3+blood 18:1/18:1-PC+blood -0.472180451 0 0 serum_fattyacid serum_phospholipids 0.792 1.34E-05 no no no no up up 22:6n3+blood 18:1/20:4-PC+blood 0 0.647058824 0 serum_fattyacid serum_phospholipids 0.792 0.582 no no no no no no 22:6n3+blood 18:1/22:6-PE+blood 0 0.769607843 0.478974359 serum_fattyacid serum_phospholipids 0.792 0.0047 no no no no up no 22:6n3+blood 18:2-LPA+blood 0 -0.551470588 0 serum_fattyacid serum_phospholipids 0.792 0.00684 no no no dn no up 22:6n3+blood 18:2-LPE+blood 0 -0.585784314 0 serum_fattyacid serum_phospholipids 0.792 0.112 no no no no no no 22:6n3+blood 18:2/18:1-PC+blood -0.503759398 0 0 serum_fattyacid serum_phospholipids 0.792 2.30E-05 no no no dn up up 22:6n3+blood 18:2/18:2-PC+blood -0.497744361 0 0 serum_fattyacid serum_phospholipids 0.792 1.98E-05 no no no dn up up 22:6n3+blood 20:0/20:4-PE+blood 0 0 -0.506324786 serum_fattyacid serum_phospholipids 0.792 0.00128 no no no up up no 22:6n3+blood 20:0/20:5-PC+blood 0 0.541666667 0 serum_fattyacid serum_phospholipids 0.792 0.882 no no no no no no 22:6n3+blood 20:0+blood -0.571428571 0 0 yes serum_fattyacid serum_fattyacid 0.792 0.000278 no no no dn no up 22:6n3+blood 20:1/20:4-PC+blood 0.529323308 0.691176471 0.579487179 serum_fattyacid serum_phospholipids 0.792 0.0419 no no no no no up 22:6n3+blood 20:1+blood -0.487218045 0 0 yes serum_fattyacid serum_fattyacid 0.792 2.56E-05 no no no dn dn dn 22:6n3+blood 20:2/18:0-PC+blood 0.518796992 0 0 serum_fattyacid serum_phospholipids 0.792 0.0427 no no no no up no 22:6n3+blood 20:3-LPE+blood 0 -0.571078431 -0.474871795 serum_fattyacid serum_phospholipids 0.792 0.084 no no no no up no 22:6n3+blood 20:3/16:0-PC+blood -0.568421053 0 0 serum_fattyacid serum_phospholipids 0.792 0.00405 no no no no up up 22:6n3+blood 20:3/18:0-PI+blood 0 0.551470588 0 serum_fattyacid serum_phospholipids 0.792 0.289 no no no no no no 22:6n3+blood 20:4/16:0-PE+blood 0 -0.544117647 0 serum_fattyacid serum_phospholipids 0.792 0.00529 no no no no up up 22:6n3+blood 20:4n6+blood 0 0.625 0 serum_fattyacid serum_fattyacid 0.792 0.133 no no no no no no 22:6n3+blood 20:5-LPC+blood 0 0.487745098 0.472136752 serum_fattyacid serum_phospholipids 0.792 0.558 no no no no no no 22:6n3+blood 20:5/18:0-PC+blood 0 0.75 0.540512821 serum_fattyacid serum_phospholipids 0.792 3.97E-06 no no no no up up 22:6n3+blood 20:5n3+blood 0.527819549 0.757352941 0.481709402 serum_fattyacid serum_fattyacid 0.792 0.988 no no no no no no 22:6n3+blood 22:0/16:0-PE+blood 0.57593985 0.585784314 0.40991453 serum_fattyacid serum_phospholipids 0.792 0.091 no no no no no up 22:6n3+blood 22:6-LPC+blood 0.646616541 0.710784314 0.752478632 serum_fattyacid serum_phospholipids 0.792 0.127 no no no no no up 22:6n3+blood Adipocytokine signaling pathway -0.463157895 0 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Alzheimer disease 0 -0.517647059 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Amyotrophic lateral sclerosis -0.461403509 -0.511764706 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Bacteroides 0 0 0.475555556 LPS-producing serum_fattyacid Genus 0.792 0.000267 no no no dn dn up 22:6n3+blood Calcium signaling pathway 0 -0.552941176 0 serum_fattyacid kegg 0.792 NA no no no no up up 22:6n3+blood cAMP signaling pathway 0 -0.529411765 0 yes serum_fattyacid kegg 0.792 NA no no no no up up 22:6n3+blood Cardiac muscle contraction 0 -0.526470588 0 serum_fattyacid kegg 0.792 NA no no no no no up 22:6n3+blood Cholinergic synapse 0 0.611764706 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Cytosolic DNA-sensing pathway -0.592982456 0 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Diabetic cardiomyopathy 0 -0.505882353 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Ferroptosis 0 -0.508823529 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood GABAergic synapse 0.48245614 0 0 serum_fattyacid kegg 0.792 NA no no no no up up 22:6n3+blood Hepatitis C 0 -0.517647059 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Huntington disease 0 -0.544117647 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.764705882 0 serum_fattyacid kegg 0.792 NA no no no no no dn 22:6n3+blood Longevity regulating pathway - multiple species 0.514035088 0 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Malaria 0 -0.614705882 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood MAPK signaling pathway 0 0.514705882 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Mineral absorption 0 -0.732352941 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Mitophagy - animal 0 -0.741176471 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Necroptosis 0 -0.7 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Non-alcoholic fatty liver disease 0 -0.602941176 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Oxidative phosphorylation 0 -0.526470588 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Parkinson disease 0 -0.602941176 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Pathways of neurodegeneration - multiple diseases 0 -0.6 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Phenylacetic acid+stool -0.582417582 0 0 serum_fattyacid stool_cometabolism 0.792 0.785 no no no no no no 22:6n3+blood Ruminococcus 0 0 0.494700855 acetate-producing serum_fattyacid Genus 0.792 0.335 no no no no no no 22:6n3+blood Shigellosis -0.505263158 -0.805882353 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Th1 and Th2 cell differentiation -0.571929825 0 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Th17 cell differentiation -0.521052632 0 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Thermogenesis -0.49122807 0 0 serum_fattyacid kegg 0.792 NA no no no no no no 22:6n3+blood Ubiquitin mediated proteolysis 0 -0.661764706 0 serum_fattyacid kegg 0.792 NA no no no no no no 24:0+blood 13-HODE+blood 0.472180451 0 0 serum_fattyacid serum_ARA 0.034 0.32 dn no up no no no 24:0+blood 14:0-LPC+blood 0 0 0.415384615 serum_fattyacid serum_phospholipids 0.034 0.00689 dn no up up up no 24:0+blood 14:0/16:0-PC+blood 0 0 0.485811966 serum_fattyacid serum_phospholipids 0.034 0.0358 dn no up no up no 24:0+blood 14:0/18:2-PC+blood 0 0.49754902 0.427008547 serum_fattyacid serum_phospholipids 0.034 0.102 dn no up no up no 24:0+blood 14:0+blood 0 0 0.436581197 yes serum_fattyacid serum_fattyacid 0.034 0.00572 dn no up up no dn 24:0+blood 16:0/16:0-PI+blood 0 0 0.460512821 serum_fattyacid serum_phospholipids 0.034 0.358 dn no up no no no 24:0+blood 16:0/18:3-PC+blood 0 0 0.426324786 serum_fattyacid serum_phospholipids 0.034 0.00216 dn no up no up up 24:0+blood 16:0/20:3-PC+blood 0 0.713235294 0 serum_fattyacid serum_phospholipids 0.034 5.43E-06 dn no up no up up 24:0+blood 18:0/18:2-PI+blood 0.485714286 0 0 serum_fattyacid serum_phospholipids 0.034 0.179 dn no up no no no 24:0+blood 18:0/20:3-PI+blood 0 0.539215686 0 serum_fattyacid serum_phospholipids 0.034 0.377 dn no up no no no 24:0+blood 18:0+blood 0 0.546568627 0 serum_fattyacid serum_fattyacid 0.034 0.344 dn no up no no no 24:0+blood 18:1/18:0-PS+blood 0 0.504901961 0 serum_fattyacid serum_phospholipids 0.034 0.193 dn no up no no no 24:0+blood 18:1/18:1-PC+blood 0 0.659313725 0 serum_fattyacid serum_phospholipids 0.034 1.34E-05 dn no up no up up 24:0+blood 18:1/20:3-PC+blood 0 0.620098039 0 serum_fattyacid serum_phospholipids 0.034 0.00872 dn no up no up up 24:0+blood 18:3-LPC+blood 0 -0.590686275 0 serum_fattyacid serum_phospholipids 0.034 0.147 dn no up no no no 24:0+blood 18:3n3+blood 0 -0.549019608 0 serum_fattyacid serum_fattyacid 0.034 0.291 dn no up no no no 24:0+blood 18:3n6+blood 0 0 0.426324786 serum_fattyacid serum_fattyacid 0.034 0.0463 dn no up up no dn 24:0+blood 20:0+blood 0 0.799019608 0.434529915 yes serum_fattyacid serum_fattyacid 0.034 0.000278 dn no up dn no up 24:0+blood 20:1-LPE+blood 0 0.698529412 0 serum_fattyacid serum_phospholipids 0.034 0.465 dn no up no no no 24:0+blood 20:1/20:4-PE+blood 0.460150376 0 0 serum_fattyacid serum_phospholipids 0.034 0.0042 dn no up up up no 24:0+blood 20:2-LPC+blood 0 0.575980392 0 serum_fattyacid serum_phospholipids 0.034 0.119 dn no up no no up 24:0+blood 20:2-LPE+blood 0 0.607843137 0 serum_fattyacid serum_phospholipids 0.034 0.177 dn no up no no no 24:0+blood 20:2+blood 0 0.566176471 0 serum_fattyacid serum_fattyacid 0.034 0.478 dn no up no no no 24:0+blood 20:3-LPC+blood 0 0 0.452991453 serum_fattyacid serum_phospholipids 0.034 0.0292 dn no up no up no 24:0+blood 20:3n6+blood 0 0 0.457777778 serum_fattyacid serum_fattyacid 0.034 0.0884 dn no up up no no 24:0+blood 20:4-LPE+blood 0 0.639705882 0 serum_fattyacid serum_phospholipids 0.034 0.552 dn no up no no no 24:0+blood Acute myeloid leukemia -0.470175439 0 0 serum_fattyacid kegg 0.034 NA dn no up no no no 24:0+blood Adipocytokine signaling pathway -0.621052632 0 0 serum_fattyacid kegg 0.034 NA dn no up no no no 24:0+blood Antigen processing and presentation 0.512280702 0 0 serum_fattyacid kegg 0.034 NA dn no up no no no 24:0+blood Bifidobacterium 0.592704066 0 0 acetate-producing serum_fattyacid Genus 0.034 0.105 dn no up no dn no 24:0+blood Biosynthesis of cofactors 0 -0.541176471 0 serum_fattyacid kegg 0.034 NA dn no up no no no 24:0+blood Gemmiger 0 0.616709478 0 butyrate-producing serum_fattyacid Genus 0.034 0.595 dn no up no no no 24:0+blood Glioma 0 0 -0.445384615 serum_fattyacid kegg 0.034 NA dn no up no no no 24:0+blood "Glycine, serine and threonine metabolism" 0 -0.632352941 0 serum_fattyacid kegg 0.034 NA dn no up no up no 24:0+blood "Growth hormone synthesis, secretion and action" -0.524561404 0 0 serum_fattyacid kegg 0.034 NA dn no up no no no 24:0+blood HCA+stool 0 0 0.565413534 serum_fattyacid stool_bileacids 0.034 0.155 dn no up no no no 24:0+blood Herpes simplex virus 1 infection 0.468421053 0 0 serum_fattyacid kegg 0.034 NA dn no up no no no 24:0+blood Human T-cell leukemia virus 1 infection 0.512280702 0 0 serum_fattyacid kegg 0.034 NA dn no up no no no 24:0+blood Kaposi sarcoma-associated herpesvirus infection 0 0 0.405384615 serum_fattyacid kegg 0.034 NA dn no up no no dn 24:0+blood L-Phenylalanine+stool 0 -0.681818182 0 serum_fattyacid stool_cometabolism 0.034 0.398 dn no up no no no 24:0+blood Lachnospira -0.476691729 0 0 butyrate-producing serum_fattyacid Genus 0.034 0.279 dn no up no no no 24:0+blood Longevity regulating pathway -0.638596491 0 0 serum_fattyacid kegg 0.034 NA dn no up no no no 24:0+blood Oocyte meiosis 0.477192982 0 -0.403846154 serum_fattyacid kegg 0.034 NA dn no up no no no 24:0+blood Paraprevotella 0.664485781 0 0 serum_fattyacid Genus 0.034 0.118 dn no up no no no 24:0+blood Porphyrin and chlorophyll metabolism 0 -0.520588235 0 serum_fattyacid kegg 0.034 NA dn no up no no no 24:0+blood Prevotella 0.460374502 0 0 serum_fattyacid Genus 0.034 0.367 dn no up no no no 24:0+blood Relaxin signaling pathway -0.478947368 0 0 serum_fattyacid kegg 0.034 NA dn no up no no no 24:0+blood Salmonella infection 0.578947368 0 0 serum_fattyacid kegg 0.034 NA dn no up no no no 24:1+blood 12-ketoDCA+blood 0 -0.559840896 0 serum_fattyacid serum_bileacids 0.00582 0.517 no dn dn no no no 24:1+blood 14:0-LPC+blood 0 0 -0.414017094 serum_fattyacid serum_phospholipids 0.00582 0.00689 no dn dn up up no 24:1+blood 16:0/14:0-PC+blood 0.610526316 0 0.60957265 serum_fattyacid serum_phospholipids 0.00582 0.0206 no dn dn no up up 24:1+blood 16:0/16:0-PC+blood 0 0 0.507692308 serum_fattyacid serum_phospholipids 0.00582 0.00079 no dn dn no up up 24:1+blood 16:0/18:1-PE+blood -0.490225564 0 0 serum_fattyacid serum_phospholipids 0.00582 0.000107 no dn dn up up no 24:1+blood 16:0/18:2-PC+blood 0 0 0.498119658 serum_fattyacid serum_phospholipids 0.00582 3.24E-06 no dn dn no up up 24:1+blood 16:0/20:4-PC+blood 0.464661654 0 0 serum_fattyacid serum_phospholipids 0.00582 0.0262 no dn dn no up no 24:1+blood 16:1/16:0-PC+blood 0.613533835 0 0.578119658 serum_fattyacid serum_phospholipids 0.00582 0.0215 no dn dn no up up 24:1+blood 16:1/16:1-PC+blood 0.512781955 0 0.595897436 serum_fattyacid serum_phospholipids 0.00582 0.0177 no dn dn no no up 24:1+blood 18:0-LPC+blood 0 -0.490196078 0 serum_fattyacid serum_phospholipids 0.00582 0.554 no dn dn no no no 24:1+blood 18:0/18:0-PE+blood -0.505263158 0 -0.72034188 serum_fattyacid serum_phospholipids 0.00582 0.00896 no dn dn up up no 24:1+blood 18:0/18:1-PE+blood -0.593984962 0 -0.669059829 serum_fattyacid serum_phospholipids 0.00582 0.00716 no dn dn up up no 24:1+blood 18:0/18:1-PG+blood 0 0 -0.420854701 serum_fattyacid serum_phospholipids 0.00582 0.000842 no dn dn no up no 24:1+blood 18:0/18:2-PC+blood 0 0 0.567863248 serum_fattyacid serum_phospholipids 0.00582 1.74E-06 no dn dn no up up 24:1+blood 18:0/22:6-PA+blood 0.481203008 0 0 serum_fattyacid serum_phospholipids 0.00582 0.22 no dn dn no no no 24:1+blood 18:1-LPE+blood -0.535338346 0 0 serum_fattyacid serum_phospholipids 0.00582 0.117 no dn dn no no no 24:1+blood 18:1/16:0-PC+blood 0 0 0.502905983 serum_fattyacid serum_phospholipids 0.00582 2.43E-05 no dn dn no up up 24:1+blood 18:1/16:0-PE+blood -0.479699248 0 -0.470769231 serum_fattyacid serum_phospholipids 0.00582 0.000182 no dn dn up up no 24:1+blood 18:1/16:1-PE+blood -0.445112782 0 0 serum_fattyacid serum_phospholipids 0.00582 0.000184 no dn dn up up no 24:1+blood 18:1/18:0-PC+blood 0 0 0.591111111 serum_fattyacid serum_phospholipids 0.00582 1.83E-06 no dn dn no up up 24:1+blood 18:1/18:0-PE+blood -0.446616541 0 0 serum_fattyacid serum_phospholipids 0.00582 1.39E-06 no dn dn up up no 24:1+blood 18:1/18:1-PE+blood -0.478195489 0 0 serum_fattyacid serum_phospholipids 0.00582 1.03E-05 no dn dn up up no 24:1+blood 18:1/18:2-PE+blood -0.559398496 0 -0.403076923 serum_fattyacid serum_phospholipids 0.00582 0.000293 no dn dn up up no 24:1+blood 18:1/20:4-PE+blood 0 0 -0.452991453 serum_fattyacid serum_phospholipids 0.00582 0.0578 no dn dn up no no 24:1+blood 18:1+blood 0 0.651960784 0 yes serum_fattyacid serum_fattyacid 0.00582 0.00202 no dn dn up no dn 24:1+blood 18:2/16:0-PC+blood 0 0 0.429059829 serum_fattyacid serum_phospholipids 0.00582 8.67E-05 no dn dn no up up 24:1+blood 18:3/16:0-PE+blood -0.493233083 0 0 serum_fattyacid serum_phospholipids 0.00582 0.00149 no dn dn up up no 24:1+blood 20:0/20:4-PE+blood 0 0 -0.578803419 serum_fattyacid serum_phospholipids 0.00582 0.00128 no dn dn up up no 24:1+blood 20:1-LPE+blood -0.448120301 0 0 serum_fattyacid serum_phospholipids 0.00582 0.465 no dn dn no no no 24:1+blood 20:1/20:4-PE+blood 0 0 -0.45982906 serum_fattyacid serum_phospholipids 0.00582 0.0042 no dn dn up up no 24:1+blood 20:2/18:1-PE+blood -0.473684211 0 -0.485128205 serum_fattyacid serum_phospholipids 0.00582 0.00208 no dn dn up up no 24:1+blood 20:3-LPE+blood 0 -0.536764706 0 serum_fattyacid serum_phospholipids 0.00582 0.084 no dn dn no up no 24:1+blood 20:3/16:0-PC+blood 0.484210526 0 0 serum_fattyacid serum_phospholipids 0.00582 0.00405 no dn dn no up up 24:1+blood 20:3/18:0-PC+blood 0.52481203 0 0.679316239 serum_fattyacid serum_phospholipids 0.00582 0.296 no dn dn no no no 24:1+blood 20:4-LPA+blood 0 0 -0.472820513 serum_fattyacid serum_phospholipids 0.00582 0.398 no dn dn no no no 24:1+blood Calcium signaling pathway 0 -0.570588235 0 serum_fattyacid kegg 0.00582 NA no dn dn no up up 24:1+blood DCA+stool 0 0 -0.717293233 serum_fattyacid stool_bileacids 0.00582 0.195 no dn dn no no no 24:1+blood Eggerthella 0 0.507149988 0 serum_fattyacid Genus 0.00582 0.912 no dn dn no no no 24:1+blood Estrogen signaling pathway -0.522807018 0 0 serum_fattyacid kegg 0.00582 NA no dn dn no no no 24:1+blood GCDCA+stool 0 0 0.445112782 yes serum_fattyacid stool_bileacids 0.00582 0.0471 no dn dn no dn no 24:1+blood GDCA+stool 0 0 0.49548249 serum_fattyacid stool_bileacids 0.00582 0.656 no dn dn no no no 24:1+blood Inflammatory bowel disease 0.528070175 0 0 serum_fattyacid kegg 0.00582 NA no dn dn no no no 24:1+blood LCA+stool 0 0 -0.654135338 serum_fattyacid stool_bileacids 0.00582 0.314 no dn dn no no no 24:1+blood Longevity regulating pathway - multiple species 0 0.523529412 0 serum_fattyacid kegg 0.00582 NA no dn dn no no no 24:1+blood Lysosome 0.489473684 0 0 serum_fattyacid kegg 0.00582 NA no dn dn no no no 24:1+blood Mineral absorption 0 -0.588235294 0 serum_fattyacid kegg 0.00582 NA no dn dn no no no 24:1+blood Morphine addiction 0 -0.508823529 0 serum_fattyacid kegg 0.00582 NA no dn dn no up up 24:1+blood Necroptosis 0 -0.55 0 serum_fattyacid kegg 0.00582 NA no dn dn no no no 24:1+blood Pancreatic cancer 0 0 -0.619230769 serum_fattyacid kegg 0.00582 NA no dn dn no no no 24:1+blood Prevotella -0.48287664 0 0 acetate-producing serum_fattyacid Genus 0.00582 0.287 no dn dn no no no 24:1+blood Propionic acid+stool 0 0 -0.74887218 yes serum_fattyacid stool_scfa 0.00582 0.0436 no dn dn dn no up 24:1+blood total_stool_scfa+stool 0 0 -0.618045113 serum_fattyacid stool_scfa 0.00582 0.0534 no dn dn dn no up 3-(3-Hydroxyphenyl)propanoic acid+stool Adlercreutzia 0 0 -0.478665697 stool_cometabolism Genus 0.33 0.548 no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool AGE-RAGE signaling pathway in diabetic complications 0.609907121 0 0 stool_cometabolism kegg 0.33 NA no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Anaerostipes 0 0 -0.425928134 butyrate-producing stool_cometabolism Genus 0.33 0.568 no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Bacteroides 0 0 0.448616601 LPS-producing stool_cometabolism Genus 0.33 0.000267 no no no dn dn up 3-(3-Hydroxyphenyl)propanoic acid+stool Carbon metabolism 0 0 -0.444381705 stool_cometabolism kegg 0.33 NA no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Central carbon metabolism in cancer 0.529411765 0 0 stool_cometabolism kegg 0.33 NA no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Coprococcus 0.558307534 0 0 butyrate-producing stool_cometabolism Genus 0.33 0.612 no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Dorea 0 0.755244755 0 stool_cometabolism Genus 0.33 0.00362 no no no up no dn 3-(3-Hydroxyphenyl)propanoic acid+stool ErbB signaling pathway 0.502579979 0 0 stool_cometabolism kegg 0.33 NA no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Fluid shear stress and atherosclerosis -0.519091847 0 0 stool_cometabolism kegg 0.33 NA no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool FoxO signaling pathway 0.560371517 0 0 stool_cometabolism kegg 0.33 NA no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Gastric cancer 0.517027864 0 0 stool_cometabolism kegg 0.33 NA no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Lachnospira 0 0 -0.468495196 butyrate-producing stool_cometabolism Genus 0.33 0.279 no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Longevity regulating pathway - multiple species 0 0 -0.422924901 stool_cometabolism kegg 0.33 NA no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Platinum drug resistance 0.616099071 0 0 stool_cometabolism kegg 0.33 NA no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Primary immunodeficiency 0 0 -0.427442123 stool_cometabolism kegg 0.33 NA no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Regulation of actin cytoskeleton -0.488132095 0 0 stool_cometabolism kegg 0.33 NA no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Roseburia -0.488132095 0 0 butyrate-producing stool_cometabolism Genus 0.33 0.495 no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Serotonergic synapse -0.504643963 0 0 stool_cometabolism kegg 0.33 NA no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Spliceosome 0.535603715 0 0 stool_cometabolism kegg 0.33 NA no no no no no no 3-(3-Hydroxyphenyl)propanoic acid+stool Tight junction -0.574819401 0 0 stool_cometabolism kegg 0.33 NA no no no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" 15-HETE+blood 0 0 0.482363244 urine_cometabolism serum_ARA 0.0125 0.819 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" 16:0-LPC+blood 0 0 0.575324675 urine_cometabolism serum_phospholipids 0.0125 0.00456 up up no up up no "3-(3,4-dihydroxyphenyl)propionic acid+urine" 16:0/18:2-PI+blood 0 0 0.437662338 urine_cometabolism serum_phospholipids 0.0125 0.269 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" 16:0/20:4-PI+blood 0 0 0.546753247 urine_cometabolism serum_phospholipids 0.0125 0.558 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" 16:0+blood 0 0.571428571 0 yes urine_cometabolism serum_fattyacid 0.0125 0.00876 up up no up no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" 18:0/16:0-PC+blood 0 0 -0.436363636 urine_cometabolism serum_phospholipids 0.0125 9.64E-07 up up no up up up "3-(3,4-dihydroxyphenyl)propionic acid+urine" 18:0/18:2-PI+blood 0 0 0.463636364 urine_cometabolism serum_phospholipids 0.0125 0.179 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" 18:1/20:3-PC+blood 0.487745098 0 0 urine_cometabolism serum_phospholipids 0.0125 0.00872 up up no no up up "3-(3,4-dihydroxyphenyl)propionic acid+urine" 18:1/20:4-PC+blood 0 0 -0.442857143 urine_cometabolism serum_phospholipids 0.0125 0.582 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" 18:2n6c+blood 0 0.620879121 0 urine_cometabolism serum_fattyacid 0.0125 0.15 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" 2-hydroxyhippuric acid+urine 0 0 -0.408547009 urine_cometabolism urine_cometabolism 0.0125 0.215 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" 2-hydroxyphenylacetic acid+urine 0 -0.461403509 0 urine_cometabolism urine_cometabolism 0.0125 0.763 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" 20:3n6+blood 0.556372549 0 0 urine_cometabolism serum_fattyacid 0.0125 0.0884 up up no up no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Alcoholism 0 0 0.403846154 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Bacterial invasion of epithelial cells 0 0.477192982 0 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Bacteroides 0.721804511 0 0 LPS-producing urine_cometabolism Genus 0.0125 0.000267 up up no dn dn up "3-(3,4-dihydroxyphenyl)propionic acid+urine" Cardiac muscle contraction 0 0 0.412307692 urine_cometabolism kegg 0.0125 NA up up no no no up "3-(3,4-dihydroxyphenyl)propionic acid+urine" Circadian entrainment -0.466666667 0 0 urine_cometabolism kegg 0.0125 NA up up no no up up "3-(3,4-dihydroxyphenyl)propionic acid+urine" Cocaine addiction 0 0 0.443846154 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Cortisol synthesis and secretion 0 0 0.430769231 urine_cometabolism kegg 0.0125 NA up up no no no up "3-(3,4-dihydroxyphenyl)propionic acid+urine" d18:1-14:0-SM+blood 0.50245098 0 0.490909091 urine_cometabolism serum_phospholipids 0.0125 0.94 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" d18:1-16:1-SM+blood 0 0 0.528571429 urine_cometabolism serum_phospholipids 0.0125 0.2 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" d18:1-18:1-SM+blood 0 0 0.454545455 urine_cometabolism serum_phospholipids 0.0125 0.916 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" d18:1-20:0-SM+blood 0 0 0.511688312 urine_cometabolism serum_phospholipids 0.0125 0.933 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" DPA+blood 0 0 -0.507792208 urine_cometabolism serum_ARA 0.0125 0.519 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Ferroptosis -0.494736842 0 0 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Fluid shear stress and atherosclerosis 0 0.459649123 0 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Gastric cancer 0.519298246 0 0 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Glutamatergic synapse 0 0 0.406153846 urine_cometabolism kegg 0.0125 NA up up no no up up "3-(3,4-dihydroxyphenyl)propionic acid+urine" Hepatocellular carcinoma 0 0.468421053 0 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Huntington disease 0 0 0.436153846 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Hypertrophic cardiomyopathy 0 0.468421053 0 urine_cometabolism kegg 0.0125 NA up up no no up up "3-(3,4-dihydroxyphenyl)propionic acid+urine" L-Citrulline+blood 0 -0.626373626 0 urine_cometabolism serum_aminoacids 0.0125 0.534 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" L-Lysine+blood 0 -0.60989011 0 yes urine_cometabolism serum_aminoacids 0.0125 0.0107 up up no no up no "3-(3,4-dihydroxyphenyl)propionic acid+urine" L-Methionine+blood 0 0 -0.448051948 urine_cometabolism serum_aminoacids 0.0125 0.626 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" L-Tryptophan+blood 0 0 -0.5 urine_cometabolism serum_aminoacids 0.0125 0.164 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Leukocyte transendothelial migration 0 0.464912281 0 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Long-term depression 0 0 0.433076923 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Morphine addiction 0 0 0.469230769 urine_cometabolism kegg 0.0125 NA up up no no up up "3-(3,4-dihydroxyphenyl)propionic acid+urine" n6+blood 0.49754902 0 0 urine_cometabolism serum_fattyacid 0.0125 0.153 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" NF-kappa B signaling pathway 0.456140351 0 0 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Non-alcoholic fatty liver disease 0 0 0.459230769 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Oxidative phosphorylation 0 0 0.423846154 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" "Parathyroid hormone synthesis, secretion and action" 0 0 0.432307692 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Parkinson disease 0 0 0.440769231 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Pathways of neurodegeneration - multiple diseases 0 0 0.445384615 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Platelet activation 0 0.473684211 0 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Rap1 signaling pathway 0 0.51754386 0 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Salivary secretion -0.457894737 0.552631579 0 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Serotonergic synapse -0.510526316 0 0 urine_cometabolism kegg 0.0125 NA up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" TCA+blood 0.504236056 0 0 urine_cometabolism serum_bileacids 0.0125 0.339 up up no no no no "3-(3,4-dihydroxyphenyl)propionic acid+urine" Thermogenesis 0 0 0.420769231 urine_cometabolism kegg 0.0125 NA up up no no no no 3-Hydroxy-L-kynurenine+urine 2-hydroxyhippuric acid+urine -0.494736842 -0.498245614 -0.478290598 urine_cometabolism urine_cometabolism 0.401 0.215 no no no no no no 3-Hydroxy-L-kynurenine+urine 2-hydroxyphenylacetic acid+urine 0 -0.515789474 0 urine_cometabolism urine_cometabolism 0.401 0.763 no no no no no no 3-Hydroxy-L-kynurenine+urine "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0.592982456 0.667692308 urine_cometabolism urine_cometabolism 0.401 0.0125 no no no up up no 3-Hydroxytyramine hydrochloride+urine 2-hydroxyhippuric acid+urine 0 0 -0.557606838 urine_cometabolism urine_cometabolism 0.288 0.215 no no no no no no 3-Hydroxytyramine hydrochloride+urine 2-hydroxyphenylacetic acid+urine 0 0 -0.526837607 urine_cometabolism urine_cometabolism 0.288 0.763 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine 12-ketoDCA+blood -0.517029533 0 0 urine_cometabolism serum_bileacids 0.973 0.517 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine 16:0/18:2-PI+blood 0 0.582417582 0 urine_cometabolism serum_phospholipids 0.973 0.269 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine 16:0/20:4-PC+blood 0 -0.653846154 0 urine_cometabolism serum_phospholipids 0.973 0.0262 no no no no up no 4-hydroxy-3-methoxymandelic acid+urine 16:0/22:6-PC+blood 0 -0.60989011 0 urine_cometabolism serum_phospholipids 0.973 4.53E-05 no no no no up up 4-hydroxy-3-methoxymandelic acid+urine 18:0/18:0-PC+blood 0 0 0.493506494 urine_cometabolism serum_phospholipids 0.973 0.426 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine 18:0/18:1-PC+blood 0 0 0.464935065 urine_cometabolism serum_phospholipids 0.973 0.393 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine 18:0/18:1-PE+blood 0 0.703296703 0 urine_cometabolism serum_phospholipids 0.973 0.00716 no no no up up no 4-hydroxy-3-methoxymandelic acid+urine 18:0/20:3-PC+blood 0 0 0.592207792 urine_cometabolism serum_phospholipids 0.973 0.0682 no no no no up no 4-hydroxy-3-methoxymandelic acid+urine 18:0/20:4-PC+blood 0 -0.631868132 0 urine_cometabolism serum_phospholipids 0.973 0.454 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine 18:0/22:6-PA+blood 0 -0.637362637 0 urine_cometabolism serum_phospholipids 0.973 0.22 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine 20:2/18:0-PC+blood 0 0 0.561038961 urine_cometabolism serum_phospholipids 0.973 0.0427 no no no no up no 4-hydroxy-3-methoxymandelic acid+urine 20:3/16:0-PC+blood 0 -0.659340659 0 urine_cometabolism serum_phospholipids 0.973 0.00405 no no no no up up 4-hydroxy-3-methoxymandelic acid+urine 20:3/18:0-PC+blood 0 -0.736263736 0 urine_cometabolism serum_phospholipids 0.973 0.296 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine 20:3n6+blood 0 0 0.444155844 urine_cometabolism serum_fattyacid 0.973 0.0884 no no no up no no 4-hydroxy-3-methoxymandelic acid+urine 20:4n6+blood 0 -0.675824176 0.524675325 urine_cometabolism serum_fattyacid 0.973 0.133 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine 20:5/18:0-PC+blood 0 -0.708791209 0 urine_cometabolism serum_phospholipids 0.973 3.97E-06 no no no no up up 4-hydroxy-3-methoxymandelic acid+urine 3-Hydroxytyramine hydrochloride+urine 0.557894737 0 0.435897436 urine_cometabolism urine_cometabolism 0.973 0.288 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine Arginine and proline metabolism 0.556140351 0 0.424615385 urine_cometabolism kegg 0.973 NA no no no no up no 4-hydroxy-3-methoxymandelic acid+urine Axon guidance -0.485964912 0.515789474 0 urine_cometabolism kegg 0.973 NA no no no no up up 4-hydroxy-3-methoxymandelic acid+urine Cushing syndrome -0.471929825 0 0 urine_cometabolism kegg 0.973 NA no no no no no up 4-hydroxy-3-methoxymandelic acid+urine DHA+blood 0 -0.637362637 0 urine_cometabolism serum_ARA 0.973 0.872 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine DL-methionine sulfoxide+blood -0.534313725 0 0 urine_cometabolism serum_aminoacids 0.973 0.302 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine Dorea 0.496240602 0 0 urine_cometabolism Genus 0.973 0.00362 no no no up no dn 4-hydroxy-3-methoxymandelic acid+urine FoxO signaling pathway 0 0 -0.469230769 urine_cometabolism kegg 0.973 NA no no no no no no 4-hydroxy-3-methoxymandelic acid+urine Gastric cancer 0 0 -0.401538462 urine_cometabolism kegg 0.973 NA no no no no no no 4-hydroxy-3-methoxymandelic acid+urine L-2-Aminobutyric acid+blood 0 -0.554945055 0.476623377 yes urine_cometabolism serum_aminoacids 0.973 0.000328 no no no up up no 4-hydroxy-3-methoxymandelic acid+urine L-Aspartic acid+blood 0 -0.565934066 0 yes urine_cometabolism serum_aminoacids 0.973 0.0226 no no no up up no 4-hydroxy-3-methoxymandelic acid+urine L-Proline+blood 0 0.763736264 0 yes urine_cometabolism serum_aminoacids 0.973 0.00265 no no no up up no 4-hydroxy-3-methoxymandelic acid+urine Lysosome 0 0.470175439 0 urine_cometabolism kegg 0.973 NA no no no no no no 4-hydroxy-3-methoxymandelic acid+urine n6+blood 0.654411765 0 0 urine_cometabolism serum_fattyacid 0.973 0.153 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine NOD-like receptor signaling pathway 0.478947368 0 0 urine_cometabolism kegg 0.973 NA no no no no no no 4-hydroxy-3-methoxymandelic acid+urine Odoribacter 0 0 -0.575887103 butyrate-producing urine_cometabolism Genus 0.973 0.798 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine p53 signaling pathway 0 -0.470175439 0 urine_cometabolism kegg 0.973 NA no no no no no no 4-hydroxy-3-methoxymandelic acid+urine Pancreatic cancer 0 0 -0.499230769 urine_cometabolism kegg 0.973 NA no no no no no no 4-hydroxy-3-methoxymandelic acid+urine Parabacteroides 0 -0.657894737 0 urine_cometabolism Genus 0.973 4.19E-05 no no no no up up 4-hydroxy-3-methoxymandelic acid+urine Peroxisome 0.538596491 0 0 urine_cometabolism kegg 0.973 NA no no no no no no 4-hydroxy-3-methoxymandelic acid+urine Pertussis 0.466666667 0 0 urine_cometabolism kegg 0.973 NA no no no no no dn 4-hydroxy-3-methoxymandelic acid+urine PUFA+blood 0.529411765 0 0 urine_cometabolism serum_fattyacid 0.973 0.212 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine Renal cell carcinoma -0.468421053 0 0 urine_cometabolism kegg 0.973 NA no no no no no no 4-hydroxy-3-methoxymandelic acid+urine Roseburia 0.526315789 0 0 butyrate-producing urine_cometabolism Genus 0.973 0.495 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine TCA+stool 0 0.711303297 0 urine_cometabolism stool_bileacids 0.973 0.458 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine TLCA+stool -0.580858437 0 0 urine_cometabolism stool_bileacids 0.973 0.243 no no no no no no 4-hydroxy-3-methoxymandelic acid+urine Wnt signaling pathway -0.470175439 0 0 urine_cometabolism kegg 0.973 NA no no no no no no 4-hydroxybenzoic acid+stool AGE-RAGE signaling pathway in diabetic complications 0 0 -0.517786561 stool_cometabolism kegg 0.0536 NA no dn no no no no 4-hydroxybenzoic acid+stool Akkermansia 0 0 -0.438823652 acetate-producing stool_cometabolism Genus 0.0536 0.23 no dn no no no no 4-hydroxybenzoic acid+stool Alistipes -0.54084914 0 0 stool_cometabolism Genus 0.0536 0.0114 no dn no no up no 4-hydroxybenzoic acid+stool Alzheimer disease 0 0 0.428571429 stool_cometabolism kegg 0.0536 NA no dn no no no no 4-hydroxybenzoic acid+stool Axon guidance 0 0 0.43308865 stool_cometabolism kegg 0.0536 NA no dn no no up up 4-hydroxybenzoic acid+stool Faecalibacterium 0.490196078 0 0 butyrate-producing stool_cometabolism Genus 0.0536 0.0039 no dn no no dn dn 4-hydroxybenzoic acid+stool JAK-STAT signaling pathway 0 0 -0.435347261 stool_cometabolism kegg 0.0536 NA no dn no no no no 4-hydroxybenzoic acid+stool Neutrophil extracellular trap formation 0.469556244 0 0 stool_cometabolism kegg 0.0536 NA no dn no no no no 4-hydroxybenzoic acid+stool NF-kappa B signaling pathway 0 0 -0.523433089 stool_cometabolism kegg 0.0536 NA no dn no no no no 4-hydroxybenzoic acid+stool Oscillospira -0.704850361 0 -0.526679842 LPS-producing stool_cometabolism Genus 0.0536 0.62 no dn no no no no 4-hydroxybenzoic acid+stool Pathways in cancer 0 0 -0.442123094 stool_cometabolism kegg 0.0536 NA no dn no no no no 4-hydroxybenzoic acid+stool Ras signaling pathway 0.502579979 0 0 yes stool_cometabolism kegg 0.0536 NA no dn no no up up 4-hydroxybenzoic acid+stool RIG-I-like receptor signaling pathway 0 0 -0.459062676 stool_cometabolism kegg 0.0536 NA no dn no no no no 4-hydroxybenzoic acid+stool Ruminococcus -0.560371517 0 0 acetate-producing stool_cometabolism Genus 0.0536 0.335 no dn no no no no 4-hydroxybenzoic acid+stool Small cell lung cancer 0 0 -0.435347261 stool_cometabolism kegg 0.0536 NA no dn no no no up 4-hydroxybenzoic acid+urine 12-ketoDCA+stool 0 0 -0.570691434 urine_cometabolism stool_bileacids 0.52 0.505 no no no no no no 4-hydroxybenzoic acid+urine "12,13-EPOME+blood" 0 0 -0.43841761 urine_cometabolism serum_ARA 0.52 0.901 no no no no no no 4-hydroxybenzoic acid+urine 13-HODE+blood 0 0 -0.441558442 urine_cometabolism serum_ARA 0.52 0.32 no no no no no no 4-hydroxybenzoic acid+urine 16:0/18:1-PC+blood 0 0 -0.471428571 urine_cometabolism serum_phospholipids 0.52 6.15E-07 no no no up up up 4-hydroxybenzoic acid+urine 16:0/18:3-PC+blood 0 0.56043956 0 urine_cometabolism serum_phospholipids 0.52 0.00216 no no no no up up 4-hydroxybenzoic acid+urine 16:0+blood 0 0 -0.525974026 yes urine_cometabolism serum_fattyacid 0.52 0.00876 no no no up no no 4-hydroxybenzoic acid+urine 16:1+blood 0 -0.664835165 0 yes urine_cometabolism serum_fattyacid 0.52 0.0186 no no no no no dn 4-hydroxybenzoic acid+urine 18:1/18:2-PG+blood 0 -0.637362637 0 urine_cometabolism serum_phospholipids 0.52 5.58E-07 no no no no up up 4-hydroxybenzoic acid+urine 22:6n3+blood 0 0 -0.449350649 urine_cometabolism serum_fattyacid 0.52 0.792 no no no no no no 4-hydroxybenzoic acid+urine 3-Hydroxytyramine hydrochloride+urine 0 0 -0.565811966 urine_cometabolism urine_cometabolism 0.52 0.288 no no no no no no 4-hydroxybenzoic acid+urine Bacteroides 0 0.5 0 LPS-producing urine_cometabolism Genus 0.52 0.000267 no no no dn dn up 4-hydroxybenzoic acid+urine Choline metabolism in cancer 0 -0.477192982 0 urine_cometabolism kegg 0.52 NA no no no no no no 4-hydroxybenzoic acid+urine Colorectal cancer 0 -0.677192982 0 urine_cometabolism kegg 0.52 NA no no no no no no 4-hydroxybenzoic acid+urine d18:1-20:1-SM+blood 0 0 0.557142857 urine_cometabolism serum_phospholipids 0.52 0.0992 no no no no no no 4-hydroxybenzoic acid+urine Gastric cancer 0 -0.492982456 0 urine_cometabolism kegg 0.52 NA no no no no no no 4-hydroxybenzoic acid+urine GCDCA+blood 0 0 0.435064935 urine_cometabolism serum_bileacids 0.52 0.31 no no no no no no 4-hydroxybenzoic acid+urine Glycine+blood 0 0.576923077 0 urine_cometabolism serum_aminoacids 0.52 0.00408 no no no dn no up 4-hydroxybenzoic acid+urine HDCA+stool 0 0 -0.570691434 urine_cometabolism stool_bileacids 0.52 0.176 no no no no no no 4-hydroxybenzoic acid+urine L-Arginine+blood 0 0.60989011 0 urine_cometabolism serum_aminoacids 0.52 0.316 no no no no no no 4-hydroxybenzoic acid+urine L-Aspartic acid+blood 0 0.554945055 0 yes urine_cometabolism serum_aminoacids 0.52 0.0226 no no no up up no 4-hydroxybenzoic acid+urine Legionellosis 0 0.466666667 0 urine_cometabolism kegg 0.52 NA no no no no no no 4-hydroxybenzoic acid+urine Leishmaniasis 0 0.470175439 0 urine_cometabolism kegg 0.52 NA no no no no no no 4-hydroxybenzoic acid+urine n3+blood 0 0 -0.485714286 urine_cometabolism serum_fattyacid 0.52 0.806 no no no no no no 4-hydroxybenzoic acid+urine Phosphatidylinositol signaling system 0 -0.484210526 0 urine_cometabolism kegg 0.52 NA no no no no no no 4-hydroxybenzoic acid+urine PUFA/MUFA+blood 0 0.637362637 0 urine_cometabolism serum_fattyacid 0.52 0.00108 no no no dn no up 4-hydroxybenzoic acid+urine SFA+blood 0 0 -0.527272727 urine_cometabolism serum_fattyacid 0.52 0.0386 no no no up no no 4-hydroxybenzoic acid+urine Signaling pathways regulating pluripotency of stem cells 0 -0.521052632 0 urine_cometabolism kegg 0.52 NA no no no no no no 4-hydroxybenzoic acid+urine Taurine+blood 0 0 -0.497402597 urine_cometabolism serum_aminoacids 0.52 0.857 no no no no no no 4-hydroxybenzoic acid+urine ToFA+blood 0 0 -0.433766234 urine_cometabolism serum_fattyacid 0.52 0.0307 no no no up no dn 4-Hydroxyphenylacetic acid+urine "12,13-EPOME+blood" 0 0.576501251 0 urine_cometabolism serum_ARA 0.0321 0.901 up up no no no no 4-Hydroxyphenylacetic acid+urine 16:0/18:0-PS+blood 0 0 -0.554545455 urine_cometabolism serum_phospholipids 0.0321 0.377 up up no no no no 4-Hydroxyphenylacetic acid+urine 16:0/18:1-PC+blood -0.566176471 0 0 urine_cometabolism serum_phospholipids 0.0321 6.15E-07 up up no up up up 4-Hydroxyphenylacetic acid+urine 18:0-LPC+blood 0.517156863 0 0 urine_cometabolism serum_phospholipids 0.0321 0.554 up up no no no no 4-Hydroxyphenylacetic acid+urine 18:0-LPE+blood 0.610294118 0 0 urine_cometabolism serum_phospholipids 0.0321 0.491 up up no no no no 4-Hydroxyphenylacetic acid+urine 18:0/16:0-PC+blood -0.580882353 0 0 urine_cometabolism serum_phospholipids 0.0321 9.64E-07 up up no up up up 4-Hydroxyphenylacetic acid+urine 18:0/18:0-PS+blood 0 0 -0.590909091 urine_cometabolism serum_phospholipids 0.0321 0.00617 up up no no up no 4-Hydroxyphenylacetic acid+urine 18:0/18:1-PE+blood 0.531862745 0 0 urine_cometabolism serum_phospholipids 0.0321 0.00716 up up no up up no 4-Hydroxyphenylacetic acid+urine 18:0/20:2-PC+blood 0.512254902 0 0 urine_cometabolism serum_phospholipids 0.0321 0.733 up up no no no no 4-Hydroxyphenylacetic acid+urine 18:0/20:3-PC+blood 0.553921569 0 0 urine_cometabolism serum_phospholipids 0.0321 0.0682 up up no no up no 4-Hydroxyphenylacetic acid+urine 18:0/20:4-PI+blood 0 0 -0.727272727 urine_cometabolism serum_phospholipids 0.0321 0.167 up up no no no no 4-Hydroxyphenylacetic acid+urine 18:0/22:6-PA+blood 0 0 -0.515584416 urine_cometabolism serum_phospholipids 0.0321 0.22 up up no no no no 4-Hydroxyphenylacetic acid+urine 18:0+blood 0.566176471 0 0 urine_cometabolism serum_fattyacid 0.0321 0.344 up up no no no no 4-Hydroxyphenylacetic acid+urine 18:1/18:2-PI+blood 0 0 0.653246753 urine_cometabolism serum_phospholipids 0.0321 0.0164 up up no dn no up 4-Hydroxyphenylacetic acid+urine 2-hydroxyphenylacetic acid+urine 0 0 0.437948718 urine_cometabolism urine_cometabolism 0.0321 0.763 up up no no no no 4-Hydroxyphenylacetic acid+urine 20:2/18:0-PC+blood 0.580882353 0 0 urine_cometabolism serum_phospholipids 0.0321 0.0427 up up no no up no 4-Hydroxyphenylacetic acid+urine 20:4/18:0-PE+blood 0 0 -0.509090909 urine_cometabolism serum_phospholipids 0.0321 0.000755 up up no up up no 4-Hydroxyphenylacetic acid+urine 22:6n3+blood 0.637254902 0 0 urine_cometabolism serum_fattyacid 0.0321 0.792 up up no no no no 4-Hydroxyphenylacetic acid+urine Apoptosis 0 0 0.403846154 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine Arachidonic acid metabolism 0 0 0.463076923 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine Autophagy - animal 0 0 -0.46 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine Axon guidance 0 0 -0.486153846 urine_cometabolism kegg 0.0321 NA up up no no up up 4-Hydroxyphenylacetic acid+urine Breast cancer 0 0 -0.429230769 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine Central carbon metabolism in cancer 0 0 -0.429230769 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine Choline metabolism in cancer 0 0 -0.409230769 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine Cytokine-cytokine receptor interaction 0 0 0.474615385 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine d18:1-24:1-SM+blood 0 -0.576923077 0 urine_cometabolism serum_phospholipids 0.0321 0.0123 up up no no dn dn 4-Hydroxyphenylacetic acid+urine DCA+stool 0 -0.866666667 0 urine_cometabolism stool_bileacids 0.0321 0.195 up up no no no no 4-Hydroxyphenylacetic acid+urine Eggerthella 0 0.488861724 0 urine_cometabolism Genus 0.0321 0.912 up up no no no no 4-Hydroxyphenylacetic acid+urine ErbB signaling pathway 0 0 -0.556153846 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine Glioma 0 0 -0.443846154 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine Glutathione metabolism 0 0 0.455384615 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine HDCA+stool -0.56043956 -0.766666667 0 urine_cometabolism stool_bileacids 0.0321 0.176 up up no no no no 4-Hydroxyphenylacetic acid+urine Herpes simplex virus 1 infection -0.484210526 0 0 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine Human T-cell leukemia virus 1 infection -0.475438596 0 0 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine iso-LCA+blood -0.503325555 0 0 urine_cometabolism serum_bileacids 0.0321 0.507 up up no no no no 4-Hydroxyphenylacetic acid+urine iso-LCA+stool 0 -0.766666667 0 urine_cometabolism stool_bileacids 0.0321 0.72 up up no no no no 4-Hydroxyphenylacetic acid+urine L-Aspartic acid+blood -0.531862745 0 0 yes urine_cometabolism serum_aminoacids 0.0321 0.0226 up up no up up no 4-Hydroxyphenylacetic acid+urine L-Histidine+blood -0.517156863 0 0 urine_cometabolism serum_aminoacids 0.0321 0.109 up up no no no no 4-Hydroxyphenylacetic acid+urine L-Phenylalanine+stool 0.556043956 0.733333333 0 urine_cometabolism stool_cometabolism 0.0321 0.398 up up no no no no 4-Hydroxyphenylacetic acid+urine L-Threonine+blood 0 0 -0.549350649 urine_cometabolism serum_aminoacids 0.0321 0.0538 up up no dn no up 4-Hydroxyphenylacetic acid+urine L-Tryptophan+stool 0.538461538 0.85 0 urine_cometabolism stool_cometabolism 0.0321 0.557 up up no no no no 4-Hydroxyphenylacetic acid+urine Lachnospira 0.472180451 0 0 butyrate-producing urine_cometabolism Genus 0.0321 0.279 up up no no no no 4-Hydroxyphenylacetic acid+urine LCA+blood -0.531791268 0 0 urine_cometabolism serum_bileacids 0.0321 0.884 up up no no no no 4-Hydroxyphenylacetic acid+urine LCA+stool 0 -0.8 0 urine_cometabolism stool_bileacids 0.0321 0.314 up up no no no no 4-Hydroxyphenylacetic acid+urine MAPK signaling pathway 0 0 -0.614615385 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine MicroRNAs in cancer 0 0 -0.452307692 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine n3+blood 0.522058824 0 0 urine_cometabolism serum_fattyacid 0.0321 0.806 up up no no no no 4-Hydroxyphenylacetic acid+urine n6/n3+blood -0.610294118 0 0 urine_cometabolism serum_fattyacid 0.0321 0.226 up up no no no no 4-Hydroxyphenylacetic acid+urine Propionic acid+stool 0 0 -0.599587203 yes urine_cometabolism stool_scfa 0.0321 0.0436 up up no dn no up 4-Hydroxyphenylacetic acid+urine PUFA+blood 0.507352941 0 0 urine_cometabolism serum_fattyacid 0.0321 0.212 up up no no no no 4-Hydroxyphenylacetic acid+urine Renal cell carcinoma 0 0 -0.402307692 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine Renin secretion 0 0 0.41 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine Signaling pathways regulating pluripotency of stem cells 0 0 -0.43 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine Sphingolipid signaling pathway 0 0 -0.413846154 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine Spinocerebellar ataxia 0 0 -0.415384615 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine T cell receptor signaling pathway 0 0 -0.493076923 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine TCA+stool 0 0 0.593395253 urine_cometabolism stool_bileacids 0.0321 0.458 up up no no no no 4-Hydroxyphenylacetic acid+urine Thyroid hormone synthesis 0 0 0.446153846 urine_cometabolism kegg 0.0321 NA up up no no no no 4-Hydroxyphenylacetic acid+urine TUDCA+blood 0.550899665 0 0 yes urine_cometabolism serum_bileacids 0.0321 0.0282 up up no no no dn 4-Hydroxyphenylacetic acid+urine Viral protein interaction with cytokine and cytokine receptor 0 0 0.411538462 urine_cometabolism kegg 0.0321 NA up up no no no no 5-HETE+blood 14:0/18:0-PC+blood 0 0 -0.422300941 serum_ARA serum_phospholipids 0.697 0.00289 no no no up up no 5-HETE+blood 14:0/20:4-PC+blood 0 -0.482269873 0 serum_ARA serum_phospholipids 0.697 0.486 no no no no no no 5-HETE+blood 15-HETE+blood 0.643350658 0 0 serum_ARA serum_ARA 0.697 0.819 no no no no no no 5-HETE+blood 16:0/16:0-PC+blood 0 0.630082458 0 serum_ARA serum_phospholipids 0.697 0.00079 no no no no up up 5-HETE+blood 16:0/16:0-PI+blood -0.572079545 0 0 serum_ARA serum_phospholipids 0.697 0.358 no no no no no no 5-HETE+blood 16:0/16:1-PI+blood -0.556230375 0 0 serum_ARA serum_phospholipids 0.697 0.262 no no no no no no 5-HETE+blood 16:0/18:1-PC+blood 0.492078975 0 0 serum_ARA serum_phospholipids 0.697 6.15E-07 no no no up up up 5-HETE+blood 16:0/18:1-PE+blood -0.560003987 0 0 serum_ARA serum_phospholipids 0.697 0.000107 no no no up up no 5-HETE+blood 16:0/18:2-PC+blood 0.554720931 0 0 serum_ARA serum_phospholipids 0.697 3.24E-06 no no no no up up 5-HETE+blood 16:0/18:2-PI+blood -0.518494258 0 0 serum_ARA serum_phospholipids 0.697 0.269 no no no no no no 5-HETE+blood 16:0/20:3-PC+blood 0 0 -0.409950954 serum_ARA serum_phospholipids 0.697 5.43E-06 no no no no up up 5-HETE+blood 16:0/20:4-PI+blood -0.492078975 0 0 serum_ARA serum_phospholipids 0.697 0.558 no no no no no no 5-HETE+blood 16:0/20:5-PC+blood 0 0 0.479934213 serum_ARA serum_phospholipids 0.697 0.628 no no no no no no 5-HETE+blood 16:0/22:0-PE+blood 0.538117039 0 0 serum_ARA serum_phospholipids 0.697 0.00839 no no no dn no up 5-HETE+blood 16:0/22:6-PC+blood 0.563022877 0 0 serum_ARA serum_phospholipids 0.697 4.53E-05 no no no no up up 5-HETE+blood 18:0/16:0-PC+blood 0.483777029 0 0 serum_ARA serum_phospholipids 0.697 9.64E-07 no no no up up up 5-HETE+blood 18:0/18:2-PC+blood 0.504909255 0 0 serum_ARA serum_phospholipids 0.697 1.74E-06 no no no no up up 5-HETE+blood 18:0/18:2-PI+blood -0.458871192 0 0 serum_ARA serum_phospholipids 0.697 0.179 no no no no no no 5-HETE+blood 18:0/20:5-PC+blood 0.826420978 0 0 serum_ARA serum_phospholipids 0.697 0.17 no no no no no no 5-HETE+blood 18:1/16:0-PC+blood 0.531324538 0 0 serum_ARA serum_phospholipids 0.697 2.43E-05 no no no no up up 5-HETE+blood 18:1/16:0-PE+blood -0.476984528 0 0 serum_ARA serum_phospholipids 0.697 0.000182 no no no up up no 5-HETE+blood 18:1/16:0-PI+blood -0.531324538 0 0 serum_ARA serum_phospholipids 0.697 0.793 no no no no no no 5-HETE+blood 18:1/16:1-PE+blood -0.495852587 0 0 serum_ARA serum_phospholipids 0.697 0.000184 no no no up up no 5-HETE+blood 18:1/18:0-PC+blood 0.536607594 0 0 serum_ARA serum_phospholipids 0.697 1.83E-06 no no no no up up 5-HETE+blood 18:1/18:1-PC+blood 0 0 -0.410637065 serum_ARA serum_phospholipids 0.697 1.34E-05 no no no no up up 5-HETE+blood 18:1/22:6-PE+blood 0 0 0.451803688 serum_ARA serum_phospholipids 0.697 0.0047 no no no no up no 5-HETE+blood 18:2/18:2-PS+blood -0.524532037 0 0 serum_ARA serum_phospholipids 0.697 0.00674 no no no up up no 5-HETE+blood 18:2/20:4-PC+blood 0.473965639 0 0 serum_ARA serum_phospholipids 0.697 0.0145 no no no no no up 5-HETE+blood 18:3n6+blood -0.529815093 0 0 serum_ARA serum_fattyacid 0.697 0.0463 no no no up no dn 5-HETE+blood 20:0-LPC+blood 0 -0.49980696 0 serum_ARA serum_phospholipids 0.697 0.199 no no no no no no 5-HETE+blood 20:0-LPE+blood -0.670948173 0 0 serum_ARA serum_phospholipids 0.697 0.0615 no no no no no up 5-HETE+blood 20:1+blood 0 0 -0.40240374 yes serum_ARA serum_fattyacid 0.697 2.56E-05 no no no dn dn dn 5-HETE+blood 20:3-LPC+blood -0.513965924 0 0 serum_ARA serum_phospholipids 0.697 0.0292 no no no no up no 5-HETE+blood 20:3-LPE+blood -0.593211771 0 0 serum_ARA serum_phospholipids 0.697 0.084 no no no no up no 5-HETE+blood 20:3n6+blood -0.68604262 0 0 serum_ARA serum_fattyacid 0.697 0.0884 no no no up no no 5-HETE+blood 20:5-LPC+blood 0 0 0.54580081 serum_ARA serum_phospholipids 0.697 0.558 no no no no no no 5-HETE+blood 20:5/18:0-PC+blood 0.450569246 0 0 serum_ARA serum_phospholipids 0.697 3.97E-06 no no no no up up 5-HETE+blood 20:5n3+blood 0 0 0.639111822 serum_ARA serum_fattyacid 0.697 0.988 no no no no no no 5-HETE+blood 22:0/16:0-PE+blood 0.548683152 0 0 serum_ARA serum_phospholipids 0.697 0.091 no no no no no up 5-Hydroxyindole-3-acetic Acid+urine 14:0/18:2-PC+blood 0 -0.554945055 0 urine_cometabolism serum_phospholipids 0.0405 0.102 no dn dn no up no 5-Hydroxyindole-3-acetic Acid+urine 14:0/20:4-PC+blood 0 0 -0.503896104 urine_cometabolism serum_phospholipids 0.0405 0.486 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine 16:0/18:0-PC+blood 0 -0.615384615 0 urine_cometabolism serum_phospholipids 0.0405 0.521 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine 16:0/18:0-PS+blood 0 0 0.436363636 urine_cometabolism serum_phospholipids 0.0405 0.377 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine 16:0/18:1-PC+blood 0 0 0.563636364 urine_cometabolism serum_phospholipids 0.0405 6.15E-07 no dn dn up up up 5-Hydroxyindole-3-acetic Acid+urine 16:0/18:3-PC+blood 0 -0.598901099 0 urine_cometabolism serum_phospholipids 0.0405 0.00216 no dn dn no up up 5-Hydroxyindole-3-acetic Acid+urine 18:0-LPC+blood 0 0 -0.453246753 urine_cometabolism serum_phospholipids 0.0405 0.554 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine 18:0/16:0-PC+blood 0 0 0.602597403 urine_cometabolism serum_phospholipids 0.0405 9.64E-07 no dn dn up up up 5-Hydroxyindole-3-acetic Acid+urine 18:1/18:2-PI+blood 0 0 -0.698701299 urine_cometabolism serum_phospholipids 0.0405 0.0164 no dn dn dn no up 5-Hydroxyindole-3-acetic Acid+urine 18:1/20:3-PC+blood -0.612745098 0 0 urine_cometabolism serum_phospholipids 0.0405 0.00872 no dn dn no up up 5-Hydroxyindole-3-acetic Acid+urine 18:2/18:1-PC+blood 0 0 -0.444155844 urine_cometabolism serum_phospholipids 0.0405 2.30E-05 no dn dn dn up up 5-Hydroxyindole-3-acetic Acid+urine 18:2/18:2-PC+blood 0 0 -0.435064935 urine_cometabolism serum_phospholipids 0.0405 1.98E-05 no dn dn dn up up 5-Hydroxyindole-3-acetic Acid+urine 18:2n6c+blood 0 -0.67032967 0 urine_cometabolism serum_fattyacid 0.0405 0.15 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine 18:3/18:2-PC+blood 0 0 -0.448051948 urine_cometabolism serum_phospholipids 0.0405 0.0394 no dn dn no no up 5-Hydroxyindole-3-acetic Acid+urine 2-hydroxyhippuric acid+urine 0 0 0.500854701 urine_cometabolism urine_cometabolism 0.0405 0.215 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 -0.467350427 urine_cometabolism urine_cometabolism 0.0405 0.0125 no dn dn up up no 5-Hydroxyindole-3-acetic Acid+urine 4-Hydroxyphenylacetic acid+urine 0 0 -0.402393162 urine_cometabolism urine_cometabolism 0.0405 0.0321 no dn dn up up no 5-Hydroxyindole-3-acetic Acid+urine Adipocytokine signaling pathway 0 0 -0.496153846 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Adrenergic signaling in cardiomyocytes 0 0.459649123 0 urine_cometabolism kegg 0.0405 NA no dn dn no no up 5-Hydroxyindole-3-acetic Acid+urine Akkermansia 0 0.554495937 0 acetate-producing urine_cometabolism Genus 0.0405 0.23 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Aldosterone synthesis and secretion 0 0.507017544 0 urine_cometabolism kegg 0.0405 NA no dn dn no up up 5-Hydroxyindole-3-acetic Acid+urine AMPK signaling pathway 0 0 -0.446153846 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Apelin signaling pathway -0.566666667 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Arachidonic acid metabolism 0 0 -0.449230769 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Arginine and proline metabolism 0 -0.501754386 0 urine_cometabolism kegg 0.0405 NA no dn dn no up no 5-Hydroxyindole-3-acetic Acid+urine Axon guidance -0.603508772 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no up up 5-Hydroxyindole-3-acetic Acid+urine Biosynthesis of amino acids 0 -0.498245614 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Biosynthesis of cofactors 0 0 -0.518461538 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Calcium signaling pathway -0.58245614 0.501754386 0 urine_cometabolism kegg 0.0405 NA no dn dn no up up 5-Hydroxyindole-3-acetic Acid+urine cGMP-PKG signaling pathway 0 -0.473684211 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Coronavirus disease - COVID-19 -0.519298246 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Dilated cardiomyopathy 0 0.456140351 0 urine_cometabolism kegg 0.0405 NA no dn dn no up up 5-Hydroxyindole-3-acetic Acid+urine EGFR tyrosine kinase inhibitor resistance -0.561403509 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Endocrine and other factor-regulated calcium reabsorption 0 0.50877193 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine EPA+blood 0 0 0.474025974 urine_cometabolism serum_ARA 0.0405 0.212 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine GABAergic synapse 0 -0.487719298 0 urine_cometabolism kegg 0.0405 NA no dn dn no up up 5-Hydroxyindole-3-acetic Acid+urine Gap junction 0 0 -0.463846154 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Gastric acid secretion 0 0.464912281 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Gastric cancer -0.487719298 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Glioma 0 0 0.408461538 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Glutamatergic synapse 0 0 -0.408461538 urine_cometabolism kegg 0.0405 NA no dn dn no up up 5-Hydroxyindole-3-acetic Acid+urine Glutathione metabolism 0 0 -0.474615385 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine "Glycine, serine and threonine metabolism" 0 0 -0.537692308 urine_cometabolism kegg 0.0405 NA no dn dn no up no 5-Hydroxyindole-3-acetic Acid+urine HIF-1 signaling pathway -0.575438596 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Hippo signaling pathway 0 0.470175439 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Hypotaurine+blood 0 0 0.474025974 urine_cometabolism serum_aminoacids 0.0405 0.933 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Inflammatory mediator regulation of TRP channels 0 0.496491228 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Insulin secretion 0 0.468421053 0 yes urine_cometabolism kegg 0.0405 NA no dn dn no up up 5-Hydroxyindole-3-acetic Acid+urine Insulin signaling pathway -0.543859649 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Kaposi sarcoma-associated herpesvirus infection -0.459649123 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no dn 5-Hydroxyindole-3-acetic Acid+urine L-Isoleucine+blood 0 0.582417582 0 yes urine_cometabolism serum_aminoacids 0.0405 5.47E-06 no dn dn up up no 5-Hydroxyindole-3-acetic Acid+urine L-Methionine+blood 0 0.565934066 0.512987013 urine_cometabolism serum_aminoacids 0.0405 0.626 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine L-Tryptophan+blood 0 0.642857143 0 urine_cometabolism serum_aminoacids 0.0405 0.164 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine LCA+stool 0.591208791 0 0 urine_cometabolism stool_bileacids 0.0405 0.314 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Long-term depression 0 0 -0.440769231 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Longevity regulating pathway 0 0 -0.44 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Malaria 0 0 -0.468461538 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Melanogenesis 0 0.633333333 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Mitophagy - animal -0.463157895 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine mRNA surveillance pathway 0 0.494736842 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine mTOR signaling pathway -0.575438596 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine MUFA%+blood 0 0 0.494805195 urine_cometabolism serum_fattyacid 0.0405 0.00142 no dn dn up no dn 5-Hydroxyindole-3-acetic Acid+urine n6+blood 0 -0.60989011 0 urine_cometabolism serum_fattyacid 0.0405 0.153 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine nutriCA+blood -0.648142091 0 0 urine_cometabolism serum_bileacids 0.0405 0.726 no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Pancreatic cancer -0.498245614 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Pancreatic secretion 0 0.60877193 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Pathways of neurodegeneration - multiple diseases 0 0 -0.406923077 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Peroxisome 0 -0.471929825 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Porphyrin and chlorophyll metabolism 0 0 -0.539230769 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine PPAR signaling pathway 0 -0.489473684 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Proteasome 0 0 0.436153846 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Proteoglycans in cancer 0 0 0.453846154 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Ras signaling pathway -0.649122807 0 0 yes urine_cometabolism kegg 0.0405 NA no dn dn no up up 5-Hydroxyindole-3-acetic Acid+urine Renal cell carcinoma -0.605263158 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Renin secretion 0 0.473684211 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Ribosome -0.519298246 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine RNA degradation 0 0.505263158 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Sphingolipid signaling pathway 0 0 0.463846154 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine TGF-beta signaling pathway -0.522807018 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Th1 and Th2 cell differentiation 0 0 0.496153846 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Th17 cell differentiation 0 0 0.472307692 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Thyroid hormone signaling pathway 0 0.489473684 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Thyroid hormone synthesis 0 0 -0.571538462 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Toxoplasmosis 0.7 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine TXB2+blood 0 0 -0.475943185 yes urine_cometabolism serum_ARA 0.0405 0.0644 no dn dn dn no no 5-Hydroxyindole-3-acetic Acid+urine Valine+blood 0 0.637362637 0 yes urine_cometabolism serum_aminoacids 0.0405 1.22E-06 no dn dn up up no 5-Hydroxyindole-3-acetic Acid+urine Vascular smooth muscle contraction -0.538596491 0 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxyindole-3-acetic Acid+urine Wnt signaling pathway -0.503508772 0.536842105 0 urine_cometabolism kegg 0.0405 NA no dn dn no no no 5-Hydroxytryptamine+urine 2-hydroxyhippuric acid+urine 0 0 -0.412649573 urine_cometabolism urine_cometabolism 0.171 0.215 no no no no no no 5-Hydroxytryptamine+urine 3-Hydroxytyramine hydrochloride+urine 0.566917293 0.610526316 0.688205128 urine_cometabolism urine_cometabolism 0.171 0.288 no no no no no no 5-Hydroxytryptamine+urine 4-hydroxy-3-methoxymandelic acid+urine 0.454135338 0 0 urine_cometabolism urine_cometabolism 0.171 0.973 no no no no no no 8-HETE+blood 11-HETE+blood 0 0 -0.517370787 serum_ARA serum_ARA 0.741 0.464 no no no no no no 8-HETE+blood 12-HEPE+blood -0.614407251 0 0 serum_ARA serum_ARA 0.741 0.312 no no no no no no 8-HETE+blood 12-ketoDCA+blood 0 0 -0.443288121 serum_ARA serum_bileacids 0.741 0.517 no no no no no no 8-HETE+blood 13-HODE+blood 0 0.659313725 0.548717949 serum_ARA serum_ARA 0.741 0.32 no no no no no no 8-HETE+blood 14:0/16:0-PC+blood 0 -0.536764706 0 serum_ARA serum_phospholipids 0.741 0.0358 no no no no up no 8-HETE+blood 16:0/16:1-PC+blood 0 -0.522058824 0 serum_ARA serum_phospholipids 0.741 0.00283 no no no up up no 8-HETE+blood 16:0/16:1-PI+blood 0 -0.598039216 0 serum_ARA serum_phospholipids 0.741 0.262 no no no no no no 8-HETE+blood 16:0/20:4-PI+blood 0 -0.573529412 0 serum_ARA serum_phospholipids 0.741 0.558 no no no no no no 8-HETE+blood 18:0-LPC+blood 0 -0.549019608 0 serum_ARA serum_phospholipids 0.741 0.554 no no no no no no 8-HETE+blood 18:0-LPE+blood 0 -0.487745098 0 serum_ARA serum_phospholipids 0.741 0.491 no no no no no no 8-HETE+blood 18:0/18:0-PS+blood 0 -0.607843137 0 serum_ARA serum_phospholipids 0.741 0.00617 no no no no up no 8-HETE+blood 18:0/18:1-PG+blood 0 -0.541666667 0 serum_ARA serum_phospholipids 0.741 0.000842 no no no no up no 8-HETE+blood 18:0/20:3-PC+blood 0 -0.524509804 0 serum_ARA serum_phospholipids 0.741 0.0682 no no no no up no 8-HETE+blood 18:1/16:0-PC+blood 0 0.50245098 0 serum_ARA serum_phospholipids 0.741 2.43E-05 no no no no up up 8-HETE+blood 18:1/18:1-PG+blood 0 -0.639705882 0 serum_ARA serum_phospholipids 0.741 0.00352 no no no no up up 8-HETE+blood 18:1/20:4-PE+blood 0.603007519 0 0 serum_ARA serum_phospholipids 0.741 0.0578 no no no up no no 8-HETE+blood 18:2/16:0-PC+blood 0 0.524509804 0 serum_ARA serum_phospholipids 0.741 8.67E-05 no no no no up up 8-HETE+blood 18:3n6+blood 0 -0.681372549 0 serum_ARA serum_fattyacid 0.741 0.0463 no no no up no dn 8-HETE+blood 20-HDOHE+blood 0 0 -0.462250164 serum_ARA serum_ARA 0.741 0.205 no no no no no no 8-HETE+blood 20:0-LPC+blood 0 0 0.515213675 serum_ARA serum_phospholipids 0.741 0.199 no no no no no no 8-HETE+blood 20:0/20:4-PE+blood 0 -0.56127451 0 serum_ARA serum_phospholipids 0.741 0.00128 no no no up up no 8-HETE+blood 20:1/20:4-PE+blood 0.578947368 -0.482843137 0 serum_ARA serum_phospholipids 0.741 0.0042 no no no up up no 8-HETE+blood 20:2/18:0-PC+blood 0 -0.529411765 0 serum_ARA serum_phospholipids 0.741 0.0427 no no no no up no 8-HETE+blood 20:2/18:1-PE+blood 0 -0.529411765 0 serum_ARA serum_phospholipids 0.741 0.00208 no no no up up no 8-HETE+blood 20:3n6+blood 0 -0.49754902 0 serum_ARA serum_fattyacid 0.741 0.0884 no no no up no no 8-HETE+blood 20:4/18:0-PE+blood 0.452631579 0 0 serum_ARA serum_phospholipids 0.741 0.000755 no no no up up no 8-HETE+blood 24:0+blood 0.560902256 0 0 serum_ARA serum_fattyacid 0.741 0.034 no no no dn no up 8-HETE+blood Adherens junction 0 0 -0.552307692 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood AGE-RAGE signaling pathway in diabetic complications 0 0 0.433076923 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Alcoholism 0 0 -0.482307692 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Antigen processing and presentation 0 0 -0.420769231 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.543076923 serum_ARA kegg 0.741 NA no no no no up up 8-HETE+blood Autophagy - animal 0 0 0.562307692 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Bacterial invasion of epithelial cells 0 0 -0.625384615 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Bacteroides 0 0 -0.435213675 LPS-producing serum_ARA Genus 0.741 0.000267 no no no dn dn up 8-HETE+blood Breast cancer 0 0 0.594615385 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Butyric acid+stool 0 0 0.502255639 yes serum_ARA stool_scfa 0.741 0.102 no no no dn no no 8-HETE+blood Chemokine signaling pathway 0 0.5 -0.453076923 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Choline metabolism in cancer 0 0 0.542307692 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Chronic myeloid leukemia 0 0 0.492307692 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Circadian entrainment 0 0 -0.494615385 serum_ARA kegg 0.741 NA no no no no up up 8-HETE+blood Colorectal cancer 0 0 0.409230769 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Cytokine-cytokine receptor interaction 0 0 -0.602307692 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood DCA+stool -0.593406593 0 0 serum_ARA stool_bileacids 0.741 0.195 no no no no no no 8-HETE+blood Dilated cardiomyopathy 0 0 -0.476153846 serum_ARA kegg 0.741 NA no no no no up up 8-HETE+blood Endocytosis 0.503508772 0 0 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood ErbB signaling pathway 0 0 0.471538462 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Fc gamma R-mediated phagocytosis 0.507017544 0 0 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Fluid shear stress and atherosclerosis 0 0 -0.498461538 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Focal adhesion 0 0 -0.502307692 serum_ARA kegg 0.741 NA no no no no up up 8-HETE+blood Gap junction 0 0 -0.41 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Gastric acid secretion 0 0 -0.532307692 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Gastric cancer 0 0 0.503076923 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Hepatitis B 0 0 0.522307692 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Hippo signaling pathway 0 0 -0.431538462 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Hypertrophic cardiomyopathy 0 0 -0.554615385 serum_ARA kegg 0.741 NA no no no no up up 8-HETE+blood Insulin resistance 0 0 0.601538462 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood L-Phenylalanine+stool 0 0.718181818 0 serum_ARA stool_cometabolism 0.741 0.398 no no no no no no 8-HETE+blood L-Tryptophan+stool 0 0.845454545 0 serum_ARA stool_cometabolism 0.741 0.557 no no no no no no 8-HETE+blood L-Tyrosine+stool 0.571428571 0 0 serum_ARA stool_cometabolism 0.741 0.44 no no no no no no 8-HETE+blood Lachnospira 0 0 0.531850095 butyrate-producing serum_ARA Genus 0.741 0.279 no no no no no no 8-HETE+blood Leukocyte transendothelial migration 0 0 -0.613076923 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood MicroRNAs in cancer 0 0 0.534615385 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Mitophagy - animal -0.485964912 0 0 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Natural killer cell mediated cytotoxicity 0.471929825 0 0 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Neutrophil extracellular trap formation 0 0 -0.423846154 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood NF-kappa B signaling pathway 0 0 0.525384615 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Non-small cell lung cancer 0 0 0.424615385 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Olfactory transduction 0.463157895 0 0 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Oocyte meiosis 0 -0.511764706 0 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Oxytocin signaling pathway 0.524561404 0 -0.553076923 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood p53 signaling pathway 0 0 0.506153846 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Pancreatic cancer 0 0 0.419230769 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Paraprevotella 0.485422563 0 0 serum_ARA Genus 0.741 0.118 no no no no no no 8-HETE+blood Pathogenic Escherichia coli infection 0.631578947 0.5 -0.456923077 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 0.493076923 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Phosphatidylinositol signaling system 0 0 0.461538462 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Platelet activation 0 0 -0.528461538 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Platinum drug resistance 0 0 0.426923077 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Prostate cancer 0 0.517647059 0.416923077 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Rap1 signaling pathway 0 0 -0.515384615 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Regulation of actin cytoskeleton 0 0 -0.647692308 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Renin secretion 0 0 -0.414615385 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Salivary secretion 0 0 -0.413846154 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Salmonella infection 0.628070175 0 -0.535384615 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Signaling pathways regulating pluripotency of stem cells 0 0 0.53 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Small cell lung cancer 0 0 0.423846154 serum_ARA kegg 0.741 NA no no no no no up 8-HETE+blood Thermogenesis 0 0 -0.407692308 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Tight junction 0 0 -0.51 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood TNF signaling pathway 0 0.532352941 0 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Transcriptional misregulation in cancer 0 0 0.542307692 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Vasopressin-regulated water reabsorption 0 0 -0.430769231 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Vibrio cholerae infection 0 0 -0.53 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Viral protein interaction with cytokine and cytokine receptor 0 0 -0.704615385 serum_ARA kegg 0.741 NA no no no no no no 8-HETE+blood Yersinia infection 0.592982456 0 -0.526923077 serum_ARA kegg 0.741 NA no no no no no no 9-HODE+blood 11-HETE+blood 0 0 -0.419130731 serum_ARA serum_ARA 0.297 0.464 no no no no no no 9-HODE+blood 12-HEPE+blood 0 0 -0.48143311 serum_ARA serum_ARA 0.297 0.312 no no no no no no 9-HODE+blood "12,13-EPOME+blood" 0.57229258 0 0 serum_ARA serum_ARA 0.297 0.901 no no no no no no 9-HODE+blood 13-HODE+blood 0 0.703431373 0 serum_ARA serum_ARA 0.297 0.32 no no no no no no 9-HODE+blood 18:0-LPC+blood 0 -0.553921569 0 serum_ARA serum_phospholipids 0.297 0.554 no no no no no no 9-HODE+blood 18:0/18:0-PC+blood -0.464661654 0 0 serum_ARA serum_phospholipids 0.297 0.426 no no no no no no 9-HODE+blood 18:0/18:0-PS+blood 0 -0.553921569 0 serum_ARA serum_phospholipids 0.297 0.00617 no no no no up no 9-HODE+blood 18:0/18:1-PG+blood 0 -0.737745098 0 serum_ARA serum_phospholipids 0.297 0.000842 no no no no up no 9-HODE+blood 18:0+blood 0 -0.573529412 0 serum_ARA serum_fattyacid 0.297 0.344 no no no no no no 9-HODE+blood 18:1/18:2-PI+blood 0.609022556 0 0 serum_ARA serum_phospholipids 0.297 0.0164 no no no dn no up 9-HODE+blood 18:2-LPA+blood 0 0.5 0 serum_ARA serum_phospholipids 0.297 0.00684 no no no dn no up 9-HODE+blood 18:2-LPC+blood 0 0.56372549 0 serum_ARA serum_phospholipids 0.297 0.00743 no no no dn no up 9-HODE+blood 18:2-LPE+blood 0 0 0.423589744 serum_ARA serum_phospholipids 0.297 0.112 no no no no no no 9-HODE+blood 18:3n6+blood 0 -0.666666667 0 serum_ARA serum_fattyacid 0.297 0.0463 no no no up no dn 9-HODE+blood 20:1/20:4-PE+blood 0 -0.50245098 0 serum_ARA serum_phospholipids 0.297 0.0042 no no no up up no 9-HODE+blood 20:2-LPC+blood 0.50075188 0 0 serum_ARA serum_phospholipids 0.297 0.119 no no no no no up 9-HODE+blood 20:2-LPE+blood 0 0 0.432478632 serum_ARA serum_phospholipids 0.297 0.177 no no no no no no 9-HODE+blood 20:2/18:1-PE+blood 0 -0.490196078 0 serum_ARA serum_phospholipids 0.297 0.00208 no no no up up no 9-HODE+blood 20:3/18:0-PI+blood 0 -0.482843137 0 serum_ARA serum_phospholipids 0.297 0.289 no no no no no no 9-HODE+blood Adherens junction 0 0 -0.449230769 serum_ARA kegg 0.297 NA no no no no no no 9-HODE+blood Alistipes -0.502645088 0 0 serum_ARA Genus 0.297 0.0114 no no no no up no 9-HODE+blood Autophagy - animal 0 0 0.412307692 serum_ARA kegg 0.297 NA no no no no no no 9-HODE+blood Axon guidance 0 0 0.430769231 serum_ARA kegg 0.297 NA no no no no up up 9-HODE+blood Central carbon metabolism in cancer 0 -0.611764706 0 serum_ARA kegg 0.297 NA no no no no no no 9-HODE+blood Clostridium 0 -0.501532896 0 serum_ARA Genus 0.297 0.925 no no no no no no 9-HODE+blood Fluid shear stress and atherosclerosis 0 0 -0.459230769 serum_ARA kegg 0.297 NA no no no no no no 9-HODE+blood Gastric acid secretion 0 0 -0.45 serum_ARA kegg 0.297 NA no no no no no no 9-HODE+blood GCDCA+stool -0.56043956 0 0 yes serum_ARA stool_bileacids 0.297 0.0471 no no no no dn no 9-HODE+blood L-Phenylalanine+stool 0 0.645454545 0 serum_ARA stool_cometabolism 0.297 0.398 no no no no no no 9-HODE+blood L-Tryptophan+stool 0 0.618181818 0 serum_ARA stool_cometabolism 0.297 0.557 no no no no no no 9-HODE+blood L-Tyrosine+stool 0 0.8 0 serum_ARA stool_cometabolism 0.297 0.44 no no no no no no 9-HODE+blood Neutrophil extracellular trap formation 0 0 -0.415384615 serum_ARA kegg 0.297 NA no no no no no no 9-HODE+blood nutriCA+stool 0 -0.853246918 0 serum_ARA stool_bileacids 0.297 0.481 no no no no no no 9-HODE+blood Oscillospira -0.527819549 0 0 LPS-producing serum_ARA Genus 0.297 0.62 no no no no no no 9-HODE+blood Oxytocin signaling pathway 0 0 -0.413076923 serum_ARA kegg 0.297 NA no no no no no no 9-HODE+blood Pancreatic cancer 0 0 0.409230769 serum_ARA kegg 0.297 NA no no no no no no 9-HODE+blood Parabacteroides -0.65112782 0 0 serum_ARA Genus 0.297 4.19E-05 no no no no up up 9-HODE+blood Ruminococcus 0.484862399 0 0 serum_ARA Genus 0.297 0.0679 no no no no no dn 9-HODE+blood Signaling pathways regulating pluripotency of stem cells 0 0 0.430769231 serum_ARA kegg 0.297 NA no no no no no no 9-HODE+blood Spliceosome 0 0 0.410769231 serum_ARA kegg 0.297 NA no no no no no no 9-HODE+blood Systemic lupus erythematosus 0 0 -0.507692308 serum_ARA kegg 0.297 NA no no no no no no 9-HODE+blood T cell receptor signaling pathway 0 0 0.588461538 serum_ARA kegg 0.297 NA no no no no no no 9-HODE+blood Tight junction 0 0 -0.561538462 serum_ARA kegg 0.297 NA no no no no no no 9-HODE+blood Transcriptional misregulation in cancer 0 0 0.443076923 serum_ARA kegg 0.297 NA no no no no no no 9-HODE+blood TUDCA+stool 0 0.610695507 0 serum_ARA stool_bileacids 0.297 0.241 no no no no no no 9-HODE+blood Vibrio cholerae infection 0 0 -0.443846154 serum_ARA kegg 0.297 NA no no no no no no "9,10-EPOME+blood" "12,13-EPOME+blood" 0.50097146 0.538708416 0.58653442 serum_ARA serum_ARA 0.801 0.901 no no no no no no "9,10-EPOME+blood" 14:0-LPC+blood 0 0 -0.411357408 serum_ARA serum_phospholipids 0.801 0.00689 no no no up up no "9,10-EPOME+blood" 14:0/16:0-PC+blood 0 0 -0.544463861 serum_ARA serum_phospholipids 0.801 0.0358 no no no no up no "9,10-EPOME+blood" 14:1/18:2-PG+blood 0 0 -0.409981631 serum_ARA serum_phospholipids 0.801 0.00259 no no no no up up "9,10-EPOME+blood" 16:0/16:0-PI+blood 0 0 -0.440592676 serum_ARA serum_phospholipids 0.801 0.358 no no no no no no "9,10-EPOME+blood" 16:0/18:3-PC+blood 0 0 -0.45847778 serum_ARA serum_phospholipids 0.801 0.00216 no no no no up up "9,10-EPOME+blood" 16:1/16:1-PC+blood 0 0.486487955 0 serum_ARA serum_phospholipids 0.801 0.0177 no no no no no up "9,10-EPOME+blood" 18:0/20:3-PC+blood 0 0 -0.413765019 serum_ARA serum_phospholipids 0.801 0.0682 no no no no up no "9,10-EPOME+blood" 18:0/22:6-PE+blood 0 0.515972073 0 serum_ARA serum_phospholipids 0.801 0.00022 no no no up up no "9,10-EPOME+blood" 18:2/18:2-PS+blood -0.600753374 0 0 serum_ARA serum_phospholipids 0.801 0.00674 no no no up up no "9,10-EPOME+blood" 20:2/18:0-PC+blood 0 0 -0.480490217 serum_ARA serum_phospholipids 0.801 0.0427 no no no no up no "9,10-EPOME+blood" 20:2/18:1-PE+blood -0.459399639 0 0 serum_ARA serum_phospholipids 0.801 0.00208 no no no up up no "9,10-EPOME+blood" 20:3-LPC+blood 0 0 -0.451598894 serum_ARA serum_phospholipids 0.801 0.0292 no no no no up no "9,10-EPOME+blood" 24:0+blood 0 0 -0.515916482 serum_ARA serum_fattyacid 0.801 0.034 no no no dn no up "9,10-EPOME+blood" ACA+stool 0 0 -0.622508781 serum_ARA stool_bileacids 0.801 0.417 no no no no no no "9,10-EPOME+blood" Adipocytokine signaling pathway 0 0 -0.442217317 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Alcoholism 0 0.595872799 0 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Axon guidance 0 0 0.530118657 serum_ARA kegg 0.801 NA no no no no up up "9,10-EPOME+blood" Bacteroides 0 0 -0.404478522 LPS-producing serum_ARA Genus 0.801 0.000267 no no no dn dn up "9,10-EPOME+blood" Cell cycle 0 0 0.422081327 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Central carbon metabolism in cancer 0 0 0.422468558 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Choline metabolism in cancer 0 -0.516226435 0.458481001 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Cholinergic synapse 0 0 0.465063921 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Chronic myeloid leukemia 0 -0.516226435 0 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Collinsella 0 0 -0.44209358 serum_ARA Genus 0.801 0.128 no no no no no no "9,10-EPOME+blood" Colorectal cancer 0 -0.681418894 0.519276201 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Cytosolic DNA-sensing pathway 0 -0.528025896 0 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" ErbB signaling pathway 0 0 0.454995926 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Ferroptosis 0 0 -0.529344196 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Gastric cancer 0 -0.589973068 0.404655951 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Glioma 0 0 0.611437078 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Glutathione metabolism 0 0 -0.404655951 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Hepatitis C 0 -0.578173607 0 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Insulin resistance 0 -0.504426973 0 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Kaposi sarcoma-associated herpesvirus infection 0 0 -0.449187467 serum_ARA kegg 0.801 NA no no no no no dn "9,10-EPOME+blood" LCA+stool 0.650180406 0 0 serum_ARA stool_bileacids 0.801 0.314 no no no no no no "9,10-EPOME+blood" Long-term potentiation 0 0 0.578135249 serum_ARA kegg 0.801 NA no no no no no up "9,10-EPOME+blood" Malaria 0 0 -0.518888971 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" MAPK signaling pathway 0 0 0.542897266 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Measles 0 -0.501477108 0 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Mineral absorption 0 0 -0.482876527 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Mitophagy - animal 0 0 -0.46467669 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Necroptosis 0 0 -0.451510851 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" nutriCA+stool -0.612614427 0 0 serum_ARA stool_bileacids 0.801 0.481 no no no no no no "9,10-EPOME+blood" Oocyte meiosis 0 0 0.51850174 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Parkinson disease 0 0 -0.540573883 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Pathways of neurodegeneration - multiple diseases 0 0 -0.553739723 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Phosphatidylinositol signaling system 0 0 0.4913956 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Porphyrin and chlorophyll metabolism 0 0 -0.422081327 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Progesterone-mediated oocyte maturation 0 0 0.405430412 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Proteoglycans in cancer 0 0 0.401558106 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Purine metabolism 0 0 -0.449961928 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Renal cell carcinoma 0 0 0.477068069 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" RNA degradation 0 0 0.44415347 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" RNA transport 0 0 0.439893933 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Shigellosis 0 0 -0.495655136 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Signaling pathways regulating pluripotency of stem cells 0 -0.587023203 0.400009184 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Small cell lung cancer 0 -0.530975762 0 serum_ARA kegg 0.801 NA no no no no no up "9,10-EPOME+blood" Spinocerebellar ataxia 0 0 0.436021628 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Spliceosome 0 0 0.450349159 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" T cell receptor signaling pathway 0 -0.581123472 0.577360788 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Th1 and Th2 cell differentiation 0 -0.660769837 0 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Th17 cell differentiation 0 -0.705017817 0 serum_ARA kegg 0.801 NA no no no no no no "9,10-EPOME+blood" Ubiquitin mediated proteolysis 0 0 -0.455770387 serum_ARA kegg 0.801 NA no no no no no no AA+blood 12-HEPE+blood -0.476528458 0 0 serum_ARA serum_ARA 0.212 0.312 no no no no no no AA+blood 12-ketoDCA+blood -0.466774616 0 0 serum_ARA serum_bileacids 0.212 0.517 no no no no no no AA+blood 13-HODE+blood 0.655639098 0 0 serum_ARA serum_ARA 0.212 0.32 no no no no no no AA+blood 14:0/18:0-PC+blood 0 -0.62254902 0 serum_ARA serum_phospholipids 0.212 0.00289 no no no up up no AA+blood 16:0-LPC+blood 0.581954887 0 0 serum_ARA serum_phospholipids 0.212 0.00456 no no no up up no AA+blood 16:0/16:1-PC+blood 0 -0.620098039 0 serum_ARA serum_phospholipids 0.212 0.00283 no no no up up no AA+blood 16:0/16:1-PI+blood 0 -0.678921569 0 serum_ARA serum_phospholipids 0.212 0.262 no no no no no no AA+blood 16:0/18:1-PE+blood 0 -0.504901961 0 serum_ARA serum_phospholipids 0.212 0.000107 no no no up up no AA+blood 16:0/18:2-PI+blood 0 -0.727941176 0 serum_ARA serum_phospholipids 0.212 0.269 no no no no no no AA+blood 16:0/20:4-PC+blood 0 0.531862745 0 serum_ARA serum_phospholipids 0.212 0.0262 no no no no up no AA+blood 16:0/20:4-PI+blood 0 -0.541666667 0 serum_ARA serum_phospholipids 0.212 0.558 no no no no no no AA+blood 16:0+blood 0.494736842 0 0 yes serum_ARA serum_fattyacid 0.212 0.00876 no no no up no no AA+blood 16:1/16:0-PC+blood 0.463157895 0 0 serum_ARA serum_phospholipids 0.212 0.0215 no no no no up up AA+blood 16:1/16:1-PC+blood 0.472180451 0 0 serum_ARA serum_phospholipids 0.212 0.0177 no no no no no up AA+blood 16:1/18:2-PG+blood 0.568421053 0 0 serum_ARA serum_phospholipids 0.212 1.40E-08 no no no no up up AA+blood 16:1+blood 0.612030075 0 0 yes serum_ARA serum_fattyacid 0.212 0.0186 no no no no no dn AA+blood 18:0-LPC+blood 0 -0.482843137 0 serum_ARA serum_phospholipids 0.212 0.554 no no no no no no AA+blood 18:0/18:0-PC+blood 0 -0.659313725 0 serum_ARA serum_phospholipids 0.212 0.426 no no no no no no AA+blood 18:0/18:1-PC+blood 0 -0.703431373 0 serum_ARA serum_phospholipids 0.212 0.393 no no no no no no AA+blood 18:0/20:2-PC+blood -0.494736842 -0.683823529 0 serum_ARA serum_phospholipids 0.212 0.733 no no no no no no AA+blood 18:0/20:3-PC+blood 0 -0.776960784 0 serum_ARA serum_phospholipids 0.212 0.0682 no no no no up no AA+blood 18:0/20:5-PC+blood 0 0.578431373 0.543931624 serum_ARA serum_phospholipids 0.212 0.17 no no no no no no AA+blood 18:1/16:1-PE+blood 0 -0.56127451 0 serum_ARA serum_phospholipids 0.212 0.000184 no no no up up no AA+blood 18:1/18:0-PE+blood 0 -0.531862745 0 serum_ARA serum_phospholipids 0.212 1.39E-06 no no no up up no AA+blood 18:1/18:0-PI+blood 0 -0.637254902 0 serum_ARA serum_phospholipids 0.212 0.0931 no no no no no up AA+blood 18:1/18:0-PS+blood 0.493233083 0 0 serum_ARA serum_phospholipids 0.212 0.193 no no no no no no AA+blood 18:1/18:1-PE+blood 0 -0.573529412 0 serum_ARA serum_phospholipids 0.212 1.03E-05 no no no up up no AA+blood 18:1/18:1-PG+blood 0 -0.691176471 0 serum_ARA serum_phospholipids 0.212 0.00352 no no no no up up AA+blood 18:1/18:2-PE+blood 0 -0.575980392 0 serum_ARA serum_phospholipids 0.212 0.000293 no no no up up no AA+blood 18:1/18:2-PG+blood 0.482706767 -0.580882353 0 serum_ARA serum_phospholipids 0.212 5.58E-07 no no no no up up AA+blood 18:2/18:2-PS+blood 0 -0.536764706 0 serum_ARA serum_phospholipids 0.212 0.00674 no no no up up no AA+blood 18:3n3+blood 0.744360902 0.676470588 0 serum_ARA serum_fattyacid 0.212 0.291 no no no no no no AA+blood 20:0-LPE+blood 0 -0.541666667 0 serum_ARA serum_phospholipids 0.212 0.0615 no no no no no up AA+blood 20:0/20:4-PE+blood 0 -0.625 0 serum_ARA serum_phospholipids 0.212 0.00128 no no no up up no AA+blood 20:0/20:5-PC+blood 0 0 0.426324786 serum_ARA serum_phospholipids 0.212 0.882 no no no no no no AA+blood 20:2/18:0-PC+blood 0 -0.779411765 0 serum_ARA serum_phospholipids 0.212 0.0427 no no no no up no AA+blood 20:2/18:1-PE+blood 0 -0.754901961 0 serum_ARA serum_phospholipids 0.212 0.00208 no no no up up no AA+blood 20:3/16:0-PC+blood 0 0.49754902 0 serum_ARA serum_phospholipids 0.212 0.00405 no no no no up up AA+blood 20:3n6+blood 0 -0.720588235 0 serum_ARA serum_fattyacid 0.212 0.0884 no no no up no no AA+blood 20:4-LPC+blood 0 0.651960784 0.491965812 serum_ARA serum_phospholipids 0.212 0.949 no no no no no no AA+blood 20:5-LPC+blood 0 0.541666667 0 serum_ARA serum_phospholipids 0.212 0.558 no no no no no no AA+blood 22:1-LPA+blood 0.505263158 0 0 serum_ARA serum_phospholipids 0.212 0.00373 no no no no up up AA+blood 22:6-LPC+blood 0 0.615196078 0 serum_ARA serum_phospholipids 0.212 0.127 no no no no no up AA+blood 24:0+blood 0.461654135 0 0 serum_ARA serum_fattyacid 0.212 0.034 no no no dn no up AA+blood 8-HETE+blood 0.670676692 0 0.518632479 serum_ARA serum_ARA 0.212 0.741 no no no no no no AA+blood 9-HODE+blood 0 0.536764706 0 serum_ARA serum_ARA 0.212 0.297 no no no no no no AA+blood Acetic acid+stool 0 0 0.466165414 yes serum_ARA stool_scfa 0.212 0.0656 no no no dn no no AA+blood Acute myeloid leukemia 0 0 0.454615385 serum_ARA kegg 0.212 NA no no no no no no AA+blood Adipocytokine signaling pathway -0.58245614 0 0 serum_ARA kegg 0.212 NA no no no no no no AA+blood Axon guidance 0 -0.664705882 0 serum_ARA kegg 0.212 NA no no no no up up AA+blood Bifidobacterium 0.580669466 0 0 acetate-producing serum_ARA Genus 0.212 0.105 no no no no dn no AA+blood Butyric acid+stool 0 0 0.658646617 yes serum_ARA stool_scfa 0.212 0.102 no no no dn no no AA+blood Coronavirus disease - COVID-19 0 0 -0.401538462 serum_ARA kegg 0.212 NA no no no no no no AA+blood Estrogen signaling pathway 0 0 -0.402307692 serum_ARA kegg 0.212 NA no no no no no no AA+blood Fc epsilon RI signaling pathway 0 0 0.565384615 serum_ARA kegg 0.212 NA no no no no no no AA+blood Lipid and atherosclerosis 0.471929825 0 0 serum_ARA kegg 0.212 NA no no no no no no AA+blood MAPK signaling pathway 0 0.629411765 0 serum_ARA kegg 0.212 NA no no no no no no AA+blood Melanogenesis 0 0 -0.448461538 serum_ARA kegg 0.212 NA no no no no no no AA+blood Mitophagy - animal -0.503508772 0 0 serum_ARA kegg 0.212 NA no no no no no no AA+blood nutriCA+stool 0 -0.633054165 0 serum_ARA stool_bileacids 0.212 0.481 no no no no no no AA+blood Paraprevotella 0.455720133 0 0 serum_ARA Genus 0.212 0.118 no no no no no no AA+blood Parkinson disease 0 0 -0.45 serum_ARA kegg 0.212 NA no no no no no no AA+blood Pathways of neurodegeneration - multiple diseases 0 0 -0.426923077 serum_ARA kegg 0.212 NA no no no no no no AA+blood Phospholipase D signaling pathway 0 0 0.499230769 serum_ARA kegg 0.212 NA no no no no up up AA+blood Protein processing in endoplasmic reticulum 0 0 -0.579230769 serum_ARA kegg 0.212 NA no no no no no no AA+blood Renin secretion 0 0 -0.42 serum_ARA kegg 0.212 NA no no no no no no AA+blood Retrograde endocannabinoid signaling 0 -0.502941176 0 serum_ARA kegg 0.212 NA no no no no no up AA+blood Ribosome 0 0 -0.401538462 serum_ARA kegg 0.212 NA no no no no no no AA+blood Roseburia 0 -0.580012371 0 butyrate-producing serum_ARA Genus 0.212 0.495 no no no no no no AA+blood Salmonella infection 0.540350877 0 0 serum_ARA kegg 0.212 NA no no no no no no AA+blood total_stool_scfa+stool 0 0 0.518796992 serum_ARA stool_scfa 0.212 0.0534 no no no dn no up ABC transporters alpha-Linolenic acid metabolism 0.529565217 0.504940711 0 kegg kegg NA NA no up up no no no ABC transporters Amino sugar and nucleotide sugar metabolism 0.573043478 0.482213439 0 kegg kegg NA NA no up up no no no ABC transporters Aminoacyl-tRNA biosynthesis 0.66173913 0 0.546203346 kegg kegg NA NA no up up no no no ABC transporters Antifolate resistance 0.652173913 0.482213439 0 kegg kegg NA NA no up up no no no ABC transporters beta-Alanine metabolism 0.492173913 0 0 kegg kegg NA NA no up up no no no ABC transporters Biosynthesis of unsaturated fatty acids 0.434782609 0 0 kegg kegg NA NA no up up no no no ABC transporters Butanoate metabolism 0.56173913 0 0 kegg kegg NA NA no up up no no no ABC transporters Carbon metabolism 0 -0.592885375 0 kegg kegg NA NA no up up no no no ABC transporters Drug metabolism - other enzymes 0 -0.450592885 0 kegg kegg NA NA no up up no no no ABC transporters EGFR tyrosine kinase inhibitor resistance 0 -0.449604743 0 kegg kegg NA NA no up up no no no ABC transporters Endocrine resistance -0.407826087 0 0 kegg kegg NA NA no up up no no no ABC transporters Fatty acid degradation 0.485217391 0 0 kegg kegg NA NA no up up no no no ABC transporters Fatty acid elongation 0 -0.433794466 0 kegg kegg NA NA no up up no no no ABC transporters Fatty acid metabolism 0.471304348 0 0 kegg kegg NA NA no up up no no no ABC transporters Folate biosynthesis 0 0 0.410810811 kegg kegg NA NA no up up no no no ABC transporters Fructose and mannose metabolism 0.597391304 0.513833992 0 kegg kegg NA NA no up up no no no ABC transporters Galactose metabolism 0.572173913 0.464426877 0.404118404 kegg kegg NA NA no up up no no no ABC transporters Glycerolipid metabolism 0.639130435 0.875494071 0.603088803 kegg kegg NA NA no up up no no up ABC transporters Glycerophospholipid metabolism 0 0.837944664 0.622393822 kegg kegg NA NA no up up no no up ABC transporters Glycolysis / Gluconeogenesis 0.410434783 -0.612648221 0 kegg kegg NA NA no up up no no no ABC transporters Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.563241107 0 kegg kegg NA NA no up up no no no ABC transporters Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.430630631 kegg kegg NA NA no up up no no no ABC transporters Glycosaminoglycan biosynthesis - keratan sulfate -0.406086957 0 0 kegg kegg NA NA no up up no no no ABC transporters Glycosphingolipid biosynthesis - globo and isoglobo series -0.472173913 0 0 kegg kegg NA NA no up up no no no ABC transporters Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.584347826 0.597826087 0 kegg kegg NA NA no up up no no no ABC transporters Histidine metabolism 0.428695652 0 0 kegg kegg NA NA no up up no no no ABC transporters Inositol phosphate metabolism 0.64173913 0.828063241 0.590990991 kegg kegg NA NA no up up no no no ABC transporters Lysine degradation 0.463478261 0.669960474 0.483912484 kegg kegg NA NA no up up no no no ABC transporters Mannose type O-glycan biosynthesis 0 0.578063241 0.491634492 kegg kegg NA NA no up up no no no ABC transporters Mucin type O-glycan biosynthesis 0 0.456521739 0 kegg kegg NA NA no up up no no no ABC transporters One carbon pool by folate 0.431304348 0 0.536936937 kegg kegg NA NA no up up no no no ABC transporters Other glycan degradation 0.589565217 0.699604743 0.522522523 kegg kegg NA NA no up up no no no ABC transporters Other types of O-glycan biosynthesis 0 0.794466403 0.544401544 kegg kegg NA NA no up up no no no ABC transporters Oxidative phosphorylation -0.410434783 -0.433794466 0 kegg kegg NA NA no up up no no no ABC transporters Platinum drug resistance 0 0.847826087 0 kegg kegg NA NA no up up no no no ABC transporters Primary bile acid biosynthesis 0.455652174 0 0 kegg kegg NA NA no up up no no no ABC transporters Propanoate metabolism 0.417391304 0 0 kegg kegg NA NA no up up no no no ABC transporters Pyrimidine metabolism 0.464347826 0 0.692406692 kegg kegg NA NA no up up no no no ABC transporters Pyruvate metabolism 0.467826087 0 0 kegg kegg NA NA no up up no no no ABC transporters Retinol metabolism 0.410434783 0 0 kegg kegg NA NA no up up no no no ABC transporters Selenocompound metabolism 0.446956522 0.733201581 0.64993565 kegg kegg NA NA no up up no no no ABC transporters Starch and sucrose metabolism 0.471304348 0 0 kegg kegg NA NA no up up no no no ABC transporters Synthesis and degradation of ketone bodies 0.431304348 0 0 kegg kegg NA NA no up up no no no ABC transporters Taurine and hypotaurine metabolism 0.424347826 0.806324111 0.504761905 kegg kegg NA NA no up up no no no ABC transporters Thiamine metabolism 0.594782609 0 0 kegg kegg NA NA no up up no no no ABC transporters Tryptophan metabolism 0.513043478 0 0 kegg kegg NA NA no up up no up no ABC transporters Ubiquinone and other terpenoid-quinone biosynthesis 0.572173913 0 0 kegg kegg NA NA no up up no no no ABC transporters "Valine, leucine and isoleucine degradation" 0.562608696 0 0 kegg kegg NA NA no up up no no no ACA+blood 16:0/16:0-PI+blood -0.504511257 0 0 serum_bileacids serum_phospholipids 0.338 0.358 no no no no no no ACA+blood 16:0/18:1-PC+blood 0.475590229 0 0 serum_bileacids serum_phospholipids 0.338 6.15E-07 no no no up up up ACA+blood 16:0/18:1-PE+blood -0.573600378 0 0 serum_bileacids serum_phospholipids 0.338 0.000107 no no no up up no ACA+blood 16:0/18:2-PC+blood 0.508528066 0 0 serum_bileacids serum_phospholipids 0.338 3.24E-06 no no no no up up ACA+blood 16:0/20:4-PC+blood 0.509331428 0 0 serum_bileacids serum_phospholipids 0.338 0.0262 no no no no up no ACA+blood 16:0/22:6-PE+blood -0.568780206 0 0 serum_bileacids serum_phospholipids 0.338 0.000934 no no no up up no ACA+blood 18:0/18:1-PE+blood 0 0 -0.410615571 serum_bileacids serum_phospholipids 0.338 0.00716 no no no up up no ACA+blood 18:0/18:2-PI+blood 0 -0.605201587 0 serum_bileacids serum_phospholipids 0.338 0.179 no no no no no no ACA+blood 18:0/20:5-PC+blood 0 0.583913089 0 serum_bileacids serum_phospholipids 0.338 0.17 no no no no no no ACA+blood 18:0/22:6-PE+blood -0.485230572 0 0 serum_bileacids serum_phospholipids 0.338 0.00022 no no no up up no ACA+blood 18:0/22:6-PI+blood -0.448275925 0 0 serum_bileacids serum_phospholipids 0.338 0.425 no no no no no no ACA+blood 18:1/16:0-PC+blood 0.545482712 0 0 serum_bileacids serum_phospholipids 0.338 2.43E-05 no no no no up up ACA+blood 18:1/16:1-PE+blood -0.453899459 0 0 serum_bileacids serum_phospholipids 0.338 0.000184 no no no up up no ACA+blood 18:1/18:0-PC+blood 0.495674276 0 0 serum_bileacids serum_phospholipids 0.338 1.83E-06 no no no no up up ACA+blood 18:1/18:1-PC+blood 0.456309544 0 0 serum_bileacids serum_phospholipids 0.338 1.34E-05 no no no no up up ACA+blood 18:1/18:1-PE+blood -0.459522992 0 0 serum_bileacids serum_phospholipids 0.338 1.03E-05 no no no up up no ACA+blood 18:1/18:2-PE+blood -0.555926416 0 0 serum_bileacids serum_phospholipids 0.338 0.000293 no no no up up no ACA+blood 18:1/22:6-PE+blood -0.449882649 0 0 serum_bileacids serum_phospholipids 0.338 0.0047 no no no no up no ACA+blood 18:2-LPA+blood 0 0 0.424125001 serum_bileacids serum_phospholipids 0.338 0.00684 no no no dn no up ACA+blood 18:2-LPE+blood 0 -0.538294879 0 serum_bileacids serum_phospholipids 0.338 0.112 no no no no no no ACA+blood 20:0-LPE+blood -0.562353311 -0.495717882 0 serum_bileacids serum_phospholipids 0.338 0.0615 no no no no no up ACA+blood 20:0/20:4-PE+blood 0 0 -0.410615571 serum_bileacids serum_phospholipids 0.338 0.00128 no no no up up no ACA+blood 20:1/20:4-PE+blood 0 0 -0.470341472 serum_bileacids serum_phospholipids 0.338 0.0042 no no no up up no ACA+blood 20:2/18:1-PE+blood -0.520578494 0 0 serum_bileacids serum_phospholipids 0.338 0.00208 no no no up up no ACA+blood 20:3/16:0-PC+blood 0.596897872 0 0 serum_bileacids serum_phospholipids 0.338 0.00405 no no no no up up ACA+blood 20:3/18:0-PC+blood 0 0 0.525801238 serum_bileacids serum_phospholipids 0.338 0.296 no no no no no no ACA+blood 20:4-LPC+blood 0 0.48659424 0 serum_bileacids serum_phospholipids 0.338 0.949 no no no no no no ACA+blood 20:4/16:0-PE+blood -0.451489373 0 0 serum_bileacids serum_phospholipids 0.338 0.00529 no no no no up up ACA+blood 20:4n6+blood 0 0.696438007 0 serum_bileacids serum_fattyacid 0.338 0.133 no no no no no no ACA+blood 20:5-LPC+blood 0 0.513965167 0 serum_bileacids serum_phospholipids 0.338 0.558 no no no no no no ACA+blood 22:2-LPA+blood 0 -0.489635454 0.528645328 serum_bileacids serum_phospholipids 0.338 0.0443 no no no dn no no ACA+blood 24:1+blood 0 0 0.482428857 serum_bileacids serum_fattyacid 0.338 0.00582 no no no no dn dn ACA+blood 4-hydroxybenzoic acid+stool 0 0 0.467639998 serum_bileacids stool_cometabolism 0.338 0.0536 no no no no dn no ACA+blood 8-HETE+blood 0 0 -0.412037616 serum_bileacids serum_ARA 0.338 0.741 no no no no no no ACA+blood Adherens junction 0 0 0.533854518 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood AMPK signaling pathway 0.561979033 0 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 0.513754574 serum_bileacids kegg 0.338 NA no no no no up up ACA+blood Autophagy - animal 0 0 -0.481594663 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Bacterial invasion of epithelial cells 0 0 0.442198772 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Blautia -0.447472564 0 0 acetate-producing serum_bileacids Genus 0.338 1.36E-05 no no no up dn dn ACA+blood Breast cancer 0 0 -0.463906712 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Butyric acid+stool 0 -0.674126972 0 yes serum_bileacids stool_scfa 0.338 0.102 no no no dn no no ACA+blood CA+stool -0.633020982 0 0 serum_bileacids stool_bileacids 0.338 0.827 no no no no no no ACA+blood Choline metabolism in cancer 0 0 -0.467122703 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Cholinergic synapse 0 0.519696405 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Chronic myeloid leukemia 0 0 -0.409234864 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Clostridium -0.495057061 0 0 serum_bileacids Genus 0.338 0.925 no no no no no no ACA+blood Clostridium -0.537336186 0 0 serum_bileacids Genus 0.338 0.925 no no no no no no ACA+blood Cytokine-cytokine receptor interaction 0 0 0.478378672 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood DCA+stool 0 0 -0.579500728 serum_bileacids stool_bileacids 0.338 0.195 no no no no no no ACA+blood ErbB signaling pathway 0 0 -0.447022759 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Fluid shear stress and atherosclerosis 0 0 0.45747473 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Gastric acid secretion 0 0 0.460690721 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Gastric cancer 0 0 -0.439786779 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Glioma 0 0.546743802 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Glutamatergic synapse 0.491499814 0 0 serum_bileacids kegg 0.338 NA no no no no up up ACA+blood HCA+stool -0.633020982 0 0 serum_bileacids stool_bileacids 0.338 0.155 no no no no no no ACA+blood Hepatitis B -0.510046977 0 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Hypertrophic cardiomyopathy 0 0 0.487222647 serum_bileacids kegg 0.338 NA no no no no up up ACA+blood IL-17 signaling pathway -0.615765805 0 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Influenza A 0 0 0.455062737 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Intestinal immune network for IgA production 0.545286586 0 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.566063371 0 serum_bileacids kegg 0.338 NA no no no no no dn ACA+blood LCA+stool 0 0 -0.527454416 serum_bileacids stool_bileacids 0.338 0.314 no no no no no no ACA+blood Leukocyte transendothelial migration 0 0 0.454258739 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Lipid and atherosclerosis -0.587945061 0 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Malaria 0 -0.5602675 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood MAPK signaling pathway 0 0.556403586 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Measles -0.552705452 0 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Mineral absorption 0 -0.577655112 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Morphine addiction 0.480371517 0 0 serum_bileacids kegg 0.338 NA no no no no up up ACA+blood Necroptosis 0 -0.564131414 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood NF-kappa B signaling pathway -0.658424279 0 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood nutriCA+stool -0.582153224 0 0 serum_bileacids stool_bileacids 0.338 0.481 no no no no no no ACA+blood Olfactory transduction -0.582380912 0 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Osteoclast differentiation -0.580526196 0 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Oxytocin signaling pathway 0 0 0.456670732 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood p53 signaling pathway 0 0 -0.512950576 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Pancreatic cancer 0 0 -0.567622424 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Pathogenic Escherichia coli infection 0 0 0.451042748 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Phagosome 0 0 0.41084286 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Phosphatidylinositol signaling system 0 0.633681862 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Platinum drug resistance 0 0 -0.456670732 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Propionic acid+stool 0 0 -0.620671691 yes serum_bileacids stool_scfa 0.338 0.0436 no no no dn no up ACA+blood Rap1 signaling pathway 0 0 0.400390889 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Renal cell carcinoma 0 0 -0.545914485 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Renin secretion 0.515611126 0 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood RIG-I-like receptor signaling pathway -0.489645098 0 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Salivary secretion 0.539722438 0 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Salmonella infection 0 0 0.477574674 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Shigellosis 0 -0.666525129 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Small cell lung cancer 0 0 -0.459082726 serum_bileacids kegg 0.338 NA no no no no no up ACA+blood Thyroid hormone synthesis 0.491499814 0 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood total_stool_scfa+stool 0 0 -0.467639998 serum_bileacids stool_scfa 0.338 0.0534 no no no dn no up ACA+blood Transcriptional misregulation in cancer -0.491499814 0 0 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Vibrio cholerae infection 0 0 0.508930587 serum_bileacids kegg 0.338 NA no no no no no no ACA+blood Yersinia infection 0 0 0.478378672 serum_bileacids kegg 0.338 NA no no no no no no ACA+stool 4-hydroxybenzoic acid+stool -0.540854486 0 0 stool_bileacids stool_cometabolism 0.417 0.0536 no no no no dn no ACA+stool AGE-RAGE signaling pathway in diabetic complications 0.598627579 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Breast cancer 0.608461297 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Chagas disease 0.577730928 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Choline metabolism in cancer 0.485539823 0 -0.445347476 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Cholinergic synapse 0.515040976 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Chronic myeloid leukemia 0.57035564 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool ErbB signaling pathway 0.669922034 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Fc epsilon RI signaling pathway 0.519957835 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Gastric cancer 0.501519614 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool "Growth hormone synthesis, secretion and action" 0.604773652 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Hepatitis B 0.519957835 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Influenza A 0 0 0.492226158 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Intestinal immune network for IgA production 0.575272499 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Neurotrophin signaling pathway 0.535937627 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Non-small cell lung cancer 0.694506328 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Phosphatidylinositol signaling system 0 0 -0.534036874 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Phospholipase D signaling pathway 0.527333124 0 0 stool_bileacids kegg 0.417 NA no no no no up up ACA+stool Prevotella -0.473298757 0 0 stool_bileacids Genus 0.417 0.367 no no no no no no ACA+stool Primary immunodeficiency -0.478164534 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Prolactin signaling pathway 0.533479197 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Prostate cancer 0.59371072 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Ras signaling pathway 0 0 -0.445347476 yes stool_bileacids kegg 0.417 NA no no no no up up ACA+stool Renal cell carcinoma 0 0 -0.508697046 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Roseburia -0.54454213 0 0 butyrate-producing stool_bileacids Genus 0.417 0.495 no no no no no no ACA+stool Signaling pathways regulating pluripotency of stem cells 0.468330816 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool TNF signaling pathway 0.537166842 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Toll-like receptor signaling pathway 0.608461297 0 0 yes stool_bileacids kegg 0.417 NA no no no no no no ACA+stool VEGF signaling pathway 0.479393749 0 0 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool Wnt signaling pathway 0 0 -0.449148451 stool_bileacids kegg 0.417 NA no no no no no no ACA+stool ¦Ø-MCA+stool 0 0.635403002 0 stool_bileacids stool_bileacids 0.417 0.919 no no no no no no acetic acid C2+blood 14:0-LPC+blood 0 0 -0.418803419 serum_scfa serum_phospholipids 0.000193 0.00689 up dn no up up no acetic acid C2+blood 14:0/16:0-PC+blood 0 -0.536764706 0 serum_scfa serum_phospholipids 0.000193 0.0358 up dn no no up no acetic acid C2+blood 14:0/18:0-PC+blood -0.538345865 0 0 serum_scfa serum_phospholipids 0.000193 0.00289 up dn no up up no acetic acid C2+blood 14:0/18:2-PC+blood 0 0 -0.433846154 serum_scfa serum_phospholipids 0.000193 0.102 up dn no no up no acetic acid C2+blood 14:0/20:4-PC+blood 0 0 -0.402393162 serum_scfa serum_phospholipids 0.000193 0.486 up dn no no no no acetic acid C2+blood 14:1/18:2-PG+blood 0 0 -0.409230769 serum_scfa serum_phospholipids 0.000193 0.00259 up dn no no up up acetic acid C2+blood 15-HETE+blood 0 0.499392968 0 serum_scfa serum_ARA 0.000193 0.819 up dn no no no no acetic acid C2+blood 16:0/14:0-PC+blood 0 -0.620098039 0 serum_scfa serum_phospholipids 0.000193 0.0206 up dn no no up up acetic acid C2+blood 16:0/16:0-PI+blood 0 0 -0.44957265 serum_scfa serum_phospholipids 0.000193 0.358 up dn no no no no acetic acid C2+blood 16:0/16:1-PC+blood -0.57593985 0 0 serum_scfa serum_phospholipids 0.000193 0.00283 up dn no up up no acetic acid C2+blood 16:0/18:1-PC+blood 0 -0.571078431 0 serum_scfa serum_phospholipids 0.000193 6.15E-07 up dn no up up up acetic acid C2+blood 16:0/18:2-PC+blood 0 -0.551470588 0 serum_scfa serum_phospholipids 0.000193 3.24E-06 up dn no no up up acetic acid C2+blood 16:0/20:3-PC+blood 0 -0.56127451 0 serum_scfa serum_phospholipids 0.000193 5.43E-06 up dn no no up up acetic acid C2+blood 16:0/22:0-PE+blood 0.454135338 0 0 serum_scfa serum_phospholipids 0.000193 0.00839 up dn no dn no up acetic acid C2+blood 16:0/22:6-PC+blood 0.460150376 0 0 serum_scfa serum_phospholipids 0.000193 4.53E-05 up dn no no up up acetic acid C2+blood 18:0-LPC+blood 0.496240602 0.509803922 0 serum_scfa serum_phospholipids 0.000193 0.554 up dn no no no no acetic acid C2+blood 18:0-LPE+blood 0.57593985 0.617647059 0 serum_scfa serum_phospholipids 0.000193 0.491 up dn no no no no acetic acid C2+blood 18:0/16:0-PC+blood 0 -0.534313725 0 serum_scfa serum_phospholipids 0.000193 9.64E-07 up dn no up up up acetic acid C2+blood 18:0/18:2-PC+blood 0 -0.625 0 serum_scfa serum_phospholipids 0.000193 1.74E-06 up dn no no up up acetic acid C2+blood 18:0/22:6-PA+blood 0 0 -0.404444444 serum_scfa serum_phospholipids 0.000193 0.22 up dn no no no no acetic acid C2+blood 18:0/22:6-PE+blood 0.518796992 0 0 serum_scfa serum_phospholipids 0.000193 0.00022 up dn no up up no acetic acid C2+blood 18:0/22:6-PI+blood 0.49924812 0 0 serum_scfa serum_phospholipids 0.000193 0.425 up dn no no no no acetic acid C2+blood 18:1/16:0-PC+blood 0 -0.504901961 0 serum_scfa serum_phospholipids 0.000193 2.43E-05 up dn no no up up acetic acid C2+blood 18:1/18:0-PC+blood 0 -0.637254902 0 serum_scfa serum_phospholipids 0.000193 1.83E-06 up dn no no up up acetic acid C2+blood 18:1/18:1-PC+blood 0 -0.566176471 0 serum_scfa serum_phospholipids 0.000193 1.34E-05 up dn no no up up acetic acid C2+blood 18:1/18:2-PI+blood 0 0.490196078 0 serum_scfa serum_phospholipids 0.000193 0.0164 up dn no dn no up acetic acid C2+blood 18:1/22:6-PE+blood 0.508270677 0 0 serum_scfa serum_phospholipids 0.000193 0.0047 up dn no no up no acetic acid C2+blood 18:3-LPC+blood -0.49924812 0 0 serum_scfa serum_phospholipids 0.000193 0.147 up dn no no no no acetic acid C2+blood 20:0-LPE+blood 0 0.615196078 0 serum_scfa serum_phospholipids 0.000193 0.0615 up dn no no no up acetic acid C2+blood 22:0/16:0-PE+blood 0.596992481 0 0 serum_scfa serum_phospholipids 0.000193 0.091 up dn no no no up acetic acid C2+blood 22:6n3+blood 0.503759398 0 0 serum_scfa serum_fattyacid 0.000193 0.792 up dn no no no no Acetic acid+stool 4-hydroxybenzoic acid+stool 0.494324045 0 0 yes stool_scfa stool_cometabolism 0.0656 0.0536 dn no no no dn no Acetic acid+stool 5-Hydroxytryptamine+stool 0 0 -0.421936759 yes stool_scfa stool_cometabolism 0.0656 0.00862 dn no no dn dn no Acetic acid+stool ACA+stool -0.507665688 0 0 yes stool_scfa stool_bileacids 0.0656 0.417 dn no no no no no Acetic acid+stool Akkermansia -0.564765508 0 0 yes acetate-producing stool_scfa Genus 0.0656 0.23 dn no no no no no Acetic acid+stool Alcoholism 0 0 -0.45567476 yes stool_scfa kegg 0.0656 NA dn no no no no no Acetic acid+stool Amoebiasis -0.525283798 0 0 yes stool_scfa kegg 0.0656 NA dn no no no no no Acetic acid+stool Chemokine signaling pathway -0.523219814 0 0 yes stool_scfa kegg 0.0656 NA dn no no no no no Acetic acid+stool Clostridium 0 0 -0.432908329 yes stool_scfa Genus 0.0656 0.925 dn no no no no no Acetic acid+stool Clostridium 0 0 0.426982963 yes stool_scfa Genus 0.0656 0.925 dn no no no no no Acetic acid+stool Phospholipase D signaling pathway -0.541795666 0 0 yes stool_scfa kegg 0.0656 NA dn no no no up up Acetic acid+stool Porphyrin and chlorophyll metabolism 0.471620227 0 0 yes stool_scfa kegg 0.0656 NA dn no no no no no Acetic acid+stool Prevotella 0 -0.694060061 0 yes acetate-producing stool_scfa Genus 0.0656 0.287 dn no no no no no Acetic acid+stool Rheumatoid arthritis -0.500515996 0 0 yes stool_scfa kegg 0.0656 NA dn no no no no no Acetic acid+stool ¦Ø-MCA+stool -0.478104177 0 0 yes stool_scfa stool_bileacids 0.0656 0.919 dn no no no no no Acute myeloid leukemia 2-Oxocarboxylic acid metabolism -0.544347826 -0.654150198 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Adipocytokine signaling pathway 0.411304348 0.545454545 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia African trypanosomiasis 0.509565217 0 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia AGE-RAGE signaling pathway in diabetic complications 0.42173913 0.774703557 0.511711712 kegg kegg NA NA no no no no no no Acute myeloid leukemia "Alanine, aspartate and glutamate metabolism" 0.419130435 0.606719368 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Aldosterone-regulated sodium reabsorption 0.649565217 0.738142292 0.528957529 kegg kegg NA NA no no no no no no Acute myeloid leukemia Alzheimer disease 0 -0.511857708 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Amino sugar and nucleotide sugar metabolism -0.44 0 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Aminoacyl-tRNA biosynthesis -0.479130435 -0.636363636 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Amoebiasis 0.49826087 0.801383399 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Amphetamine addiction 0 -0.54743083 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Amyotrophic lateral sclerosis 0 -0.552371542 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Apelin signaling pathway 0 -0.653162055 -0.443500644 kegg kegg NA NA no no no no no no Acute myeloid leukemia Apoptosis 0 0.714426877 0.478507079 kegg kegg NA NA no no no no no no Acute myeloid leukemia Arachidonic acid metabolism -0.469565217 0 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Arginine and proline metabolism 0 0.673913043 0.417760618 kegg kegg NA NA no no no no up no Acute myeloid leukemia Arginine biosynthesis 0.442608696 0.589920949 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Ascorbate and aldarate metabolism -0.430434783 0 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Autophagy - animal 0.486956522 0.712450593 0.555212355 kegg kegg NA NA no no no no no no Acute myeloid leukemia B cell receptor signaling pathway 0.410434783 0.742094862 0.642213642 kegg kegg NA NA no no no no no no Acute myeloid leukemia Bacteroides 0 -0.536561265 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Acute myeloid leukemia Basal transcription factors 0 -0.496047431 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Base excision repair -0.467826087 0 -0.402316602 kegg kegg NA NA no no no no no no Acute myeloid leukemia beta-Alanine metabolism -0.447826087 -0.613636364 -0.419305019 kegg kegg NA NA no no no no no no Acute myeloid leukemia Biosynthesis of amino acids 0 0.41798419 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Biosynthesis of cofactors -0.56 -0.524703557 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Biosynthesis of unsaturated fatty acids -0.710434783 -0.641304348 -0.456370656 kegg kegg NA NA no no no no no no Acute myeloid leukemia Bladder cancer 0.563478261 0.836956522 0.591248391 kegg kegg NA NA no no no no no no Acute myeloid leukemia Butanoate metabolism -0.595652174 -0.863636364 -0.652767053 kegg kegg NA NA no no no no no no Acute myeloid leukemia C-type lectin receptor signaling pathway 0.686956522 0.736166008 0.718918919 kegg kegg NA NA no no no no no no Acute myeloid leukemia cAMP signaling pathway 0 0.584980237 0 yes kegg kegg NA NA no no no no up up Acute myeloid leukemia Carbohydrate digestion and absorption 0.582608696 0.740118577 0.568597169 kegg kegg NA NA no no no no no no Acute myeloid leukemia Cardiac muscle contraction 0 -0.479249012 0 kegg kegg NA NA no no no no no up Acute myeloid leukemia Cell cycle -0.464347826 -0.550395257 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Cellular senescence 0 0.543478261 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia cGMP-PKG signaling pathway 0.595652174 0.57312253 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Chagas disease 0.437391304 0.756916996 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Chemokine signaling pathway 0.49826087 0.675889328 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Cholesterol metabolism 0 0 0.408494208 yes kegg kegg NA NA no no no no no up Acute myeloid leukemia Chronic myeloid leukemia 0.484347826 0.730237154 0.604890605 kegg kegg NA NA no no no no no no Acute myeloid leukemia Circadian entrainment 0 -0.461462451 -0.43011583 kegg kegg NA NA no no no no up up Acute myeloid leukemia Citrate cycle (TCA cycle) -0.646956522 -0.878458498 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Complement and coagulation cascades 0 0.510869565 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Coronavirus disease - COVID-19 0 -0.499011858 -0.450965251 kegg kegg NA NA no no no no no no Acute myeloid leukemia Cysteine and methionine metabolism -0.562608696 -0.83201581 -0.574259974 kegg kegg NA NA no no no no no no Acute myeloid leukemia Cytosolic DNA-sensing pathway 0 0.475296443 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia DNA replication -0.66 -0.813241107 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Drug metabolism - cytochrome P450 -0.482608696 -0.759881423 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Drug metabolism - other enzymes 0 -0.70256917 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia ECM-receptor interaction -0.704347826 0 0 kegg kegg NA NA no no no no up up Acute myeloid leukemia EGFR tyrosine kinase inhibitor resistance 0 -0.490118577 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Endometrial cancer 0.766086957 0.848814229 0.55032175 kegg kegg NA NA no no no no no no Acute myeloid leukemia Epithelial cell signaling in Helicobacter pylori infection 0.548695652 0.636363636 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia ErbB signaling pathway 0.544347826 0.62944664 0.435006435 kegg kegg NA NA no no no no no no Acute myeloid leukemia Estrogen signaling pathway -0.527826087 -0.718379447 -0.497039897 kegg kegg NA NA no no no no no no Acute myeloid leukemia Ether lipid metabolism 0 -0.459486166 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Fanconi anemia pathway -0.587826087 -0.481225296 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Fatty acid biosynthesis 0.493043478 0.617588933 0.518918919 kegg kegg NA NA no no no no no no Acute myeloid leukemia Fatty acid elongation -0.522608696 -0.579051383 -0.486743887 kegg kegg NA NA no no no no no no Acute myeloid leukemia Fc epsilon RI signaling pathway 0.72173913 0.805335968 0.801544402 kegg kegg NA NA no no no no no no Acute myeloid leukemia Fc gamma R-mediated phagocytosis 0 0.421936759 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Ferroptosis 0 0.476284585 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Focal adhesion 0 -0.467391304 0 kegg kegg NA NA no no no no up up Acute myeloid leukemia Fructose and mannose metabolism 0 0.442687747 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia GABAergic synapse 0 0.532608696 0 kegg kegg NA NA no no no no up up Acute myeloid leukemia Gastric acid secretion 0 -0.43972332 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Glioma 0.416521739 0 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Glucagon signaling pathway 0 -0.531620553 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Glutamatergic synapse 0 0.470355731 0 kegg kegg NA NA no no no no up up Acute myeloid leukemia Glutathione metabolism -0.413913043 -0.42687747 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia "Glycine, serine and threonine metabolism" -0.44173913 0 0 kegg kegg NA NA no no no no up no Acute myeloid leukemia Glycolysis / Gluconeogenesis -0.517391304 -0.681818182 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.724347826 0.788537549 0.477734878 kegg kegg NA NA no no no no no no Acute myeloid leukemia Glycosaminoglycan degradation 0.435652174 0 0 kegg kegg NA NA no no no no no up Acute myeloid leukemia Glycosphingolipid biosynthesis - ganglio series 0 -0.520750988 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Glycosphingolipid biosynthesis - lacto and neolacto series 0.413913043 0.45256917 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Glyoxylate and dicarboxylate metabolism 0 0.604743083 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia GnRH secretion 0.611304348 0.683794466 0.529214929 kegg kegg NA NA no no no no up up Acute myeloid leukemia "Growth hormone synthesis, secretion and action" 0.476521739 0.551383399 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Hematopoietic cell lineage 0 -0.454545455 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Hepatitis B 0.495652174 0.700592885 0.696782497 kegg kegg NA NA no no no no no no Acute myeloid leukemia Hepatitis C 0.417391304 0.510869565 0.582239382 kegg kegg NA NA no no no no no no Acute myeloid leukemia HIF-1 signaling pathway 0 -0.514822134 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Hippo signaling pathway 0 -0.450592885 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Hippo signaling pathway - multiple species 0 0.505928854 0.485456885 kegg kegg NA NA no no no no no no Acute myeloid leukemia Homologous recombination -0.46173913 0 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Human papillomavirus infection 0 0.568181818 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Huntington disease 0 -0.514822134 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia IL-17 signaling pathway 0.571304348 0.595849802 0.535392535 kegg kegg NA NA no no no no no no Acute myeloid leukemia Inflammatory mediator regulation of TRP channels 0 -0.48715415 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Insulin resistance 0 0.760869565 0.521750322 kegg kegg NA NA no no no no no no Acute myeloid leukemia Insulin signaling pathway 0 -0.593873518 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia JAK-STAT signaling pathway 0.452173913 0.572134387 0.428314028 kegg kegg NA NA no no no no no no Acute myeloid leukemia Legionellosis 0 0 -0.458172458 kegg kegg NA NA no no no no no no Acute myeloid leukemia Leishmaniasis -0.428695652 0 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Linoleic acid metabolism 0 -0.420948617 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Long-term potentiation 0 -0.685770751 0 kegg kegg NA NA no no no no no up Acute myeloid leukemia Lysosome 0.593043478 0.434782609 0.502187902 kegg kegg NA NA no no no no no no Acute myeloid leukemia Melanogenesis 0 -0.470355731 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Melanoma 0.719130435 0.831027668 0.606177606 kegg kegg NA NA no no no no no no Acute myeloid leukemia Metabolism of xenobiotics by cytochrome P450 -0.449565217 -0.768774704 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia MicroRNAs in cancer 0 0.785573123 0.48030888 kegg kegg NA NA no no no no no no Acute myeloid leukemia Mismatch repair -0.772173913 -0.779644269 -0.561904762 kegg kegg NA NA no no no no no no Acute myeloid leukemia mTOR signaling pathway 0 -0.488142292 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Mucin type O-glycan biosynthesis -0.452173913 0 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia N-Glycan biosynthesis 0 -0.611660079 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Natural killer cell mediated cytotoxicity 0 0.43083004 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Neurotrophin signaling pathway 0.502608696 0.729249012 0.484169884 kegg kegg NA NA no no no no no no Acute myeloid leukemia Neutrophil extracellular trap formation 0 0.453557312 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia NF-kappa B signaling pathway 0 0.758893281 0.663063063 kegg kegg NA NA no no no no no no Acute myeloid leukemia Nicotinate and nicotinamide metabolism 0.514782609 0.701581028 0.517889318 kegg kegg NA NA no no no no no no Acute myeloid leukemia Nicotine addiction 0 0 0.441698842 kegg kegg NA NA no no no no up up Acute myeloid leukemia Nitrogen metabolism 0.454782609 0.621541502 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia NOD-like receptor signaling pathway 0 0.609683794 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Non-alcoholic fatty liver disease 0 -0.415019763 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Non-homologous end-joining -0.613913043 -0.684782609 -0.568339768 kegg kegg NA NA no no no no no no Acute myeloid leukemia Notch signaling pathway 0.557391304 0.575098814 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Nucleotide excision repair -0.7 -0.777667984 -0.5001287 kegg kegg NA NA no no no no no no Acute myeloid leukemia One carbon pool by folate -0.603478261 -0.65513834 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Oocyte meiosis 0 -0.73715415 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Osteoclast differentiation 0.508695652 0.619565217 0.623423423 kegg kegg NA NA no no no no no no Acute myeloid leukemia Oxidative phosphorylation 0 -0.500988142 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Pancreatic cancer 0.566956522 0 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Pantothenate and CoA biosynthesis 0.429565217 0.469367589 0 kegg kegg NA NA no no no no no dn Acute myeloid leukemia Parkinson disease 0 -0.449604743 -0.411068211 kegg kegg NA NA no no no no no no Acute myeloid leukemia Pathways in cancer 0 0.591897233 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Pathways of neurodegeneration - multiple diseases 0 -0.453557312 -0.427541828 kegg kegg NA NA no no no no no no Acute myeloid leukemia Pentose and glucuronate interconversions -0.736521739 -0.849802372 -0.445302445 kegg kegg NA NA no no no no no no Acute myeloid leukemia Pentose phosphate pathway 0 0.469367589 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Pertussis 0 0.466403162 0 kegg kegg NA NA no no no no no dn Acute myeloid leukemia Phenylalanine metabolism -0.435652174 -0.741106719 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Phospholipase D signaling pathway 0.609565217 0.76284585 0.510939511 kegg kegg NA NA no no no no up up Acute myeloid leukemia Phototransduction 0 -0.690711462 -0.61029601 kegg kegg NA NA no no no no no no Acute myeloid leukemia PPAR signaling pathway 0 0.58201581 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Prevotella 0 0.417710244 0 acetate-producing kegg Genus NA 0.287 no no no no no no Acute myeloid leukemia Primary bile acid biosynthesis -0.734782609 -0.66798419 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Prion disease 0 -0.605731225 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Prolactin signaling pathway 0.747826087 0.753952569 0.749292149 kegg kegg NA NA no no no no no no Acute myeloid leukemia Propanoate metabolism -0.5 -0.791501976 -0.515830116 kegg kegg NA NA no no no no no no Acute myeloid leukemia Prostate cancer 0.484347826 0.756916996 0.567310167 kegg kegg NA NA no no no no no no Acute myeloid leukemia Proteasome 0 -0.668972332 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Protein digestion and absorption 0 0 0.51994852 yes kegg kegg NA NA no no no no up up Acute myeloid leukemia Protein export 0 -0.622529644 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Protein processing in endoplasmic reticulum -0.674782609 -0.66798419 -0.566795367 kegg kegg NA NA no no no no no no Acute myeloid leukemia Proteoglycans in cancer 0 -0.45256917 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Proximal tubule bicarbonate reclamation -0.703478261 -0.643280632 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Pyrimidine metabolism 0 -0.62055336 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Pyruvate metabolism -0.585217391 -0.831027668 -0.547490347 kegg kegg NA NA no no no no no no Acute myeloid leukemia Ras signaling pathway 0 -0.515810277 0 yes kegg kegg NA NA no no no no up up Acute myeloid leukemia Regulation of actin cytoskeleton 0 -0.507905138 -0.509137709 kegg kegg NA NA no no no no no no Acute myeloid leukemia Relaxin signaling pathway 0 0.697628458 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Renin secretion 0 -0.557312253 -0.420592021 kegg kegg NA NA no no no no no no Acute myeloid leukemia Renin-angiotensin system 0 0.47826087 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Retinol metabolism -0.507826087 -0.684782609 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Retrograde endocannabinoid signaling 0 -0.540513834 0 kegg kegg NA NA no no no no no up Acute myeloid leukemia Ribosome 0 -0.509881423 -0.453796654 kegg kegg NA NA no no no no no no Acute myeloid leukemia Ribosome biogenesis in eukaryotes -0.411304348 -0.609683794 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia RIG-I-like receptor signaling pathway 0.502608696 0.759881423 0.587644788 kegg kegg NA NA no no no no no no Acute myeloid leukemia RNA degradation 0 -0.536561265 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia RNA polymerase 0 -0.68972332 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia RNA transport -0.427826087 -0.513833992 -0.546203346 kegg kegg NA NA no no no no no no Acute myeloid leukemia Sarcina 0 0.444554224 0 kegg Genus NA 0.0703 no no no no no no Acute myeloid leukemia Signaling pathways regulating pluripotency of stem cells 0.413913043 0 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Sphingolipid metabolism 0.527826087 0 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Sphingolipid signaling pathway 0.666956522 0.595849802 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Starch and sucrose metabolism 0 0.486166008 0.434234234 kegg kegg NA NA no no no no no no Acute myeloid leukemia Steroid biosynthesis -0.412173913 -0.688735178 -0.443243243 kegg kegg NA NA no no no no no no Acute myeloid leukemia Steroid hormone biosynthesis -0.569565217 -0.646245059 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Synaptic vesicle cycle 0.597391304 0 0.44967825 kegg kegg NA NA no no no no up up Acute myeloid leukemia Synthesis and degradation of ketone bodies -0.567826087 -0.732213439 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Taste transduction 0 -0.688735178 0 kegg kegg NA NA no no no no no up Acute myeloid leukemia Taurine and hypotaurine metabolism 0 0.459486166 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Terpenoid backbone biosynthesis -0.415652174 -0.533596838 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia TGF-beta signaling pathway 0 -0.578063241 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Thermogenesis 0 -0.563241107 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Thiamine metabolism 0 -0.665019763 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia TNF signaling pathway 0.519130435 0.754940711 0.524839125 kegg kegg NA NA no no no no no no Acute myeloid leukemia Toll-like receptor signaling pathway 0.576521739 0.77173913 0.547747748 yes kegg kegg NA NA no no no no no no Acute myeloid leukemia Transcriptional misregulation in cancer 0 0.699604743 0.457142857 kegg kegg NA NA no no no no no no Acute myeloid leukemia Tryptophan metabolism -0.576521739 -0.732213439 0 kegg kegg NA NA no no no no up no Acute myeloid leukemia Type II diabetes mellitus 0.724347826 0.755928854 0.737966538 kegg kegg NA NA no no no no no no Acute myeloid leukemia Tyrosine metabolism -0.646086957 -0.774703557 -0.550579151 kegg kegg NA NA no no no no no no Acute myeloid leukemia Ubiquinone and other terpenoid-quinone biosynthesis -0.592173913 -0.769762846 -0.410553411 kegg kegg NA NA no no no no no no Acute myeloid leukemia "Valine, leucine and isoleucine degradation" -0.653043478 -0.838932806 -0.467696268 kegg kegg NA NA no no no no no no Acute myeloid leukemia Various types of N-glycan biosynthesis 0 -0.491106719 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Vascular smooth muscle contraction 0 -0.480237154 -0.485971686 kegg kegg NA NA no no no no no no Acute myeloid leukemia VEGF signaling pathway 0.650434783 0.751976285 0.406949807 kegg kegg NA NA no no no no no no Acute myeloid leukemia Viral carcinogenesis 0 0.601778656 0 kegg kegg NA NA no no no no no no Acute myeloid leukemia Vitamin digestion and absorption 0 0 0.527155727 kegg kegg NA NA no no no no no no Acute myeloid leukemia Wnt signaling pathway 0 -0.518774704 0 kegg kegg NA NA no no no no no no Adherens junction 2-Oxocarboxylic acid metabolism 0 0.42687747 0 kegg kegg NA NA no no no no no no Adherens junction ABC transporters 0 -0.635375494 0 kegg kegg NA NA no no no no up up Adherens junction Adrenergic signaling in cardiomyocytes 0 0.42687747 0 kegg kegg NA NA no no no no no up Adherens junction "Alanine, aspartate and glutamate metabolism" 0 -0.693675889 0 kegg kegg NA NA no no no no no no Adherens junction alpha-Linolenic acid metabolism 0 -0.5 0 kegg kegg NA NA no no no no no no Adherens junction Apelin signaling pathway -0.415652174 0.5 0 kegg kegg NA NA no no no no no no Adherens junction Apoptosis 0.473043478 0 0.458429858 kegg kegg NA NA no no no no no no Adherens junction Apoptosis - multiple species -0.746086957 -0.677865613 0 kegg kegg NA NA no no no no no no Adherens junction Arginine and proline metabolism 0 -0.574110672 0 kegg kegg NA NA no no no no up no Adherens junction Arginine biosynthesis 0 -0.628458498 0 kegg kegg NA NA no no no no no no Adherens junction Ascorbate and aldarate metabolism 0 0.43972332 0 kegg kegg NA NA no no no no no no Adherens junction Autophagy - animal -0.734782609 -0.865612648 -0.52020592 kegg kegg NA NA no no no no no no Adherens junction Autophagy - other -0.827826087 -0.7756917 -0.508365508 kegg kegg NA NA no no no no no no Adherens junction Basal transcription factors -0.71826087 0 0 kegg kegg NA NA no no no no no no Adherens junction Base excision repair -0.680869565 0 0 kegg kegg NA NA no no no no no no Adherens junction Bifidobacterium 0 0.497277404 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Adherens junction Butanoate metabolism 0 0.445652174 0 kegg kegg NA NA no no no no no no Adherens junction Calcium signaling pathway 0 0.473320158 0 kegg kegg NA NA no no no no up up Adherens junction Carbon metabolism 0 0.443675889 0 kegg kegg NA NA no no no no no no Adherens junction Cardiac muscle contraction 0 0.690711462 0.596653797 kegg kegg NA NA no no no no no up Adherens junction Citrate cycle (TCA cycle) 0 0.471343874 0 kegg kegg NA NA no no no no no no Adherens junction Cytokine-cytokine receptor interaction 0 0 0.603346203 kegg kegg NA NA no no no no no no Adherens junction Drug metabolism - cytochrome P450 0 0.608695652 0 kegg kegg NA NA no no no no no no Adherens junction Drug metabolism - other enzymes 0 0.719367589 0 kegg kegg NA NA no no no no no no Adherens junction EGFR tyrosine kinase inhibitor resistance -0.436521739 0 0 kegg kegg NA NA no no no no no no Adherens junction ErbB signaling pathway -0.419130435 -0.549407115 0 kegg kegg NA NA no no no no no no Adherens junction Fanconi anemia pathway -0.406956522 0 0 kegg kegg NA NA no no no no no no Adherens junction Fatty acid biosynthesis 0 -0.599802372 0 kegg kegg NA NA no no no no no no Adherens junction Fatty acid degradation 0 -0.625494071 0 kegg kegg NA NA no no no no no no Adherens junction Fatty acid metabolism 0 -0.550395257 0 kegg kegg NA NA no no no no no no Adherens junction Focal adhesion 0.88 0.938735178 0.893436293 kegg kegg NA NA no no no no up up Adherens junction Folate biosynthesis 0 0.434782609 0 kegg kegg NA NA no no no no no no Adherens junction FoxO signaling pathway -0.49826087 -0.78458498 0 kegg kegg NA NA no no no no no no Adherens junction Fructose and mannose metabolism 0 -0.462450593 0 kegg kegg NA NA no no no no no no Adherens junction Glutathione metabolism 0 0.425889328 0 kegg kegg NA NA no no no no no no Adherens junction Glycerolipid metabolism 0 -0.647233202 0 kegg kegg NA NA no no no no no up Adherens junction Glycerophospholipid metabolism -0.477391304 -0.675889328 0 kegg kegg NA NA no no no no no up Adherens junction Glycolysis / Gluconeogenesis 0 0.611660079 0 kegg kegg NA NA no no no no no no Adherens junction Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.672924901 0 kegg kegg NA NA no no no no no no Adherens junction Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.53826087 0 0 kegg kegg NA NA no no no no no no Adherens junction Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.420869565 0 0 kegg kegg NA NA no no no no no no Adherens junction Glyoxylate and dicarboxylate metabolism 0 -0.621541502 0 kegg kegg NA NA no no no no no no Adherens junction HIF-1 signaling pathway -0.562608696 0.479249012 0 kegg kegg NA NA no no no no no no Adherens junction Hippo signaling pathway 0.914782609 0.924901186 0.918404118 kegg kegg NA NA no no no no no no Adherens junction Hippo signaling pathway - multiple species 0 -0.545454545 0 kegg kegg NA NA no no no no no no Adherens junction Homologous recombination -0.422608696 -0.501976285 0 kegg kegg NA NA no no no no no no Adherens junction Inositol phosphate metabolism 0 -0.631422925 0 kegg kegg NA NA no no no no no no Adherens junction Lachnospira 0 0.618729942 -0.420103442 butyrate-producing kegg Genus NA 0.279 no no no no no no Adherens junction Longevity regulating pathway 0 -0.541501976 0 kegg kegg NA NA no no no no no no Adherens junction Lysine degradation -0.480869565 0 0 kegg kegg NA NA no no no no no no Adherens junction MAPK signaling pathway 0 -0.675889328 0 kegg kegg NA NA no no no no no no Adherens junction Metabolism of xenobiotics by cytochrome P450 0 0.651185771 0 kegg kegg NA NA no no no no no no Adherens junction mTOR signaling pathway -0.422608696 0 0 kegg kegg NA NA no no no no no no Adherens junction Mucin type O-glycan biosynthesis 0 -0.650197628 0 kegg kegg NA NA no no no no no no Adherens junction N-Glycan biosynthesis 0 0.457509881 0 kegg kegg NA NA no no no no no no Adherens junction NF-kappa B signaling pathway -0.430434783 -0.75 -0.575289575 kegg kegg NA NA no no no no no no Adherens junction Nicotinate and nicotinamide metabolism 0 -0.511857708 0 kegg kegg NA NA no no no no no no Adherens junction Nitrogen metabolism 0 -0.621541502 0 kegg kegg NA NA no no no no no no Adherens junction Oocyte meiosis 0 0.425889328 0 kegg kegg NA NA no no no no no no Adherens junction Osteoclast differentiation 0 -0.463438735 0 kegg kegg NA NA no no no no no no Adherens junction Other glycan degradation 0 -0.500988142 0 kegg kegg NA NA no no no no no no Adherens junction Other types of O-glycan biosynthesis -0.493913043 -0.434782609 0 kegg kegg NA NA no no no no no no Adherens junction Oxidative phosphorylation 0 0.690711462 0.604118404 kegg kegg NA NA no no no no no no Adherens junction p53 signaling pathway -0.792173913 -0.691699605 -0.473616474 kegg kegg NA NA no no no no no no Adherens junction Pantothenate and CoA biosynthesis 0 -0.510869565 0 kegg kegg NA NA no no no no no dn Adherens junction Pentose and glucuronate interconversions 0 0.473320158 0 kegg kegg NA NA no no no no no no Adherens junction Peroxisome 0 -0.56916996 0 kegg kegg NA NA no no no no no no Adherens junction Phagosome 0.43826087 0 0.413899614 kegg kegg NA NA no no no no no no Adherens junction Phenylalanine metabolism 0.613913043 0.613636364 0.573487773 kegg kegg NA NA no no no no no no Adherens junction Phospholipase D signaling pathway 0 -0.489130435 0 kegg kegg NA NA no no no no up up Adherens junction PI3K-Akt signaling pathway -0.451304348 0 0 yes kegg kegg NA NA no no no no up up Adherens junction Platinum drug resistance -0.789565217 -0.621541502 0 kegg kegg NA NA no no no no no no Adherens junction PPAR signaling pathway 0 -0.523715415 0 kegg kegg NA NA no no no no no no Adherens junction Proteasome -0.482608696 0.537549407 0 kegg kegg NA NA no no no no no no Adherens junction Protein export -0.506956522 0.568181818 0 kegg kegg NA NA no no no no no no Adherens junction Pyrimidine metabolism 0 0 -0.416473616 kegg kegg NA NA no no no no no no Adherens junction Pyruvate metabolism 0 0.416996047 0 kegg kegg NA NA no no no no no no Adherens junction Rap1 signaling pathway 0.892173913 0.873517787 0.848391248 kegg kegg NA NA no no no no no no Adherens junction Ras signaling pathway 0 0.564229249 0 yes kegg kegg NA NA no no no no up up Adherens junction Ribosome 0 0.562252964 0 kegg kegg NA NA no no no no no no Adherens junction Ribosome biogenesis in eukaryotes -0.580869565 0 0 kegg kegg NA NA no no no no no no Adherens junction RNA polymerase -0.688695652 0 0 kegg kegg NA NA no no no no no no Adherens junction RNA transport -0.416521739 0 0 kegg kegg NA NA no no no no no no Adherens junction Selenocompound metabolism -0.710434783 -0.477272727 0 kegg kegg NA NA no no no no no no Adherens junction SNARE interactions in vesicular transport 0 -0.701581028 0 kegg kegg NA NA no no no no no no Adherens junction Spliceosome -0.788695652 -0.622529644 0 kegg kegg NA NA no no no no no no Adherens junction Starch and sucrose metabolism 0 -0.528656126 0 kegg kegg NA NA no no no no no no Adherens junction Taurine and hypotaurine metabolism -0.422608696 -0.649209486 0 kegg kegg NA NA no no no no no no Adherens junction Terpenoid backbone biosynthesis -0.476521739 0 0 kegg kegg NA NA no no no no no no Adherens junction TGF-beta signaling pathway 0 0.549407115 0 kegg kegg NA NA no no no no no no Adherens junction Thiamine metabolism 0 0 -0.47979408 kegg kegg NA NA no no no no no no Adherens junction Tyrosine metabolism 0 0.462450593 0 kegg kegg NA NA no no no no no no Adherens junction Various types of N-glycan biosynthesis -0.524347826 0 0 kegg kegg NA NA no no no no no no Adherens junction Vascular smooth muscle contraction 0 0.693675889 0 kegg kegg NA NA no no no no no no Adherens junction Viral protein interaction with cytokine and cytokine receptor 0 0 0.423938224 kegg kegg NA NA no no no no no no Adherens junction Wnt signaling pathway 0 0.481225296 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway 2-Oxocarboxylic acid metabolism 0 -0.556324111 -0.655598456 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Adherens junction 0 -0.59486166 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway "Alanine, aspartate and glutamate metabolism" 0 0.519762846 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway alpha-Linolenic acid metabolism 0 0 -0.574517375 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Aminoacyl-tRNA biosynthesis -0.525217391 -0.459486166 -0.404118404 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway AMPK signaling pathway 0.467826087 0 0.834749035 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Apelin signaling pathway 0 -0.432806324 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Apoptosis 0 0.431818182 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Arginine and proline metabolism 0 0.468379447 0 kegg kegg NA NA no no no no up no Adipocytokine signaling pathway Arginine biosynthesis 0 0.536561265 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Ascorbate and aldarate metabolism -0.413043478 -0.523715415 -0.480566281 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Autophagy - animal 0 0.666996047 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Autophagy - other 0 0.422924901 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway B cell receptor signaling pathway 0 0.568181818 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Basal transcription factors -0.427826087 0 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Base excision repair -0.48173913 0 -0.503732304 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway beta-Alanine metabolism 0 -0.730237154 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Biosynthesis of cofactors 0 0 0.683912484 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Biosynthesis of unsaturated fatty acids -0.740869565 -0.548418972 -0.526383526 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Butanoate metabolism -0.424347826 -0.701581028 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway C-type lectin receptor signaling pathway 0 0.631422925 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway cAMP signaling pathway 0 0.755928854 0.534362934 yes kegg kegg NA NA no no no no up up Adipocytokine signaling pathway Carbon metabolism 0 -0.483201581 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Cell cycle -0.67826087 0 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Circadian entrainment 0 -0.516798419 0 kegg kegg NA NA no no no no up up Adipocytokine signaling pathway Citrate cycle (TCA cycle) -0.616521739 -0.707509881 -0.64993565 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Clostridium -0.452707121 -0.459481269 0 kegg Genus NA 0.925 no no no no no no Adipocytokine signaling pathway Cysteine and methionine metabolism -0.649565217 -0.699604743 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Cytosolic DNA-sensing pathway 0.482608696 0.799407115 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway DNA replication -0.68173913 -0.67687747 -0.492921493 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Drug metabolism - cytochrome P450 0 -0.722332016 -0.548777349 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Drug metabolism - other enzymes 0 -0.645256917 -0.413384813 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway ECM-receptor interaction -0.426956522 0 0 kegg kegg NA NA no no no no up up Adipocytokine signaling pathway Endocrine resistance 0 0 0.437065637 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Estrogen signaling pathway -0.652173913 -0.590909091 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Fanconi anemia pathway -0.69826087 0 -0.478764479 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Fatty acid elongation -0.632173913 -0.679841897 -0.527155727 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Fatty acid metabolism -0.459130435 0 -0.411325611 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Fc epsilon RI signaling pathway 0 0.456521739 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Fc gamma R-mediated phagocytosis -0.413913043 0 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Ferroptosis 0.56 0.528656126 0.729214929 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Focal adhesion 0 -0.674901186 0 kegg kegg NA NA no no no no up up Adipocytokine signaling pathway Gap junction 0 0 0.426254826 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Glutamatergic synapse 0 0.456521739 0.4996139 kegg kegg NA NA no no no no up up Adipocytokine signaling pathway Glutathione metabolism 0 0 0.51994852 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Glycerolipid metabolism 0 0 -0.438610039 kegg kegg NA NA no no no no no up Adipocytokine signaling pathway Glycerophospholipid metabolism 0 0 -0.408494208 kegg kegg NA NA no no no no no up Adipocytokine signaling pathway "Glycine, serine and threonine metabolism" 0 0 0.761132561 kegg kegg NA NA no no no no up no Adipocytokine signaling pathway Glycolysis / Gluconeogenesis 0 -0.619565217 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.572134387 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.490118577 -0.554182754 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Glycosaminoglycan degradation 0 0 -0.562676963 kegg kegg NA NA no no no no no up Adipocytokine signaling pathway Glycosphingolipid biosynthesis - globo and isoglobo series 0 0 0.413384813 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.520750988 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Hematopoietic cell lineage 0 -0.708498024 -0.407979408 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway HIF-1 signaling pathway 0 -0.424901186 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Hippo signaling pathway 0 -0.636363636 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Hippo signaling pathway - multiple species 0 0 -0.442471042 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Homologous recombination -0.673913043 0 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Insulin secretion 0 0 0.443758044 yes kegg kegg NA NA no no no no up up Adipocytokine signaling pathway Insulin signaling pathway 0 -0.421936759 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway JAK-STAT signaling pathway 0 0.479249012 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Leukocyte transendothelial migration 0 -0.416007905 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Linoleic acid metabolism 0 -0.414031621 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Long-term depression 0 0.42687747 0.466409266 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Long-term potentiation 0 -0.482213439 -0.451222651 kegg kegg NA NA no no no no no up Adipocytokine signaling pathway Longevity regulating pathway 0.633043478 0.732213439 0.901930502 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Longevity regulating pathway - multiple species -0.773043478 -0.422924901 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway MAPK signaling pathway -0.439130435 0 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.769762846 -0.544916345 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Mismatch repair -0.748695652 -0.654150198 -0.471814672 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Mitophagy - animal 0.615652174 0 0.643243243 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Mucin type O-glycan biosynthesis -0.629565217 0 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway N-Glycan biosynthesis -0.446086957 -0.530632411 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Necroptosis 0.517391304 0.450592885 0.649420849 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Neurotrophin signaling pathway 0 0.653162055 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway NF-kappa B signaling pathway 0 0.707509881 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Nitrogen metabolism 0 0.599802372 0.506048906 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway NOD-like receptor signaling pathway 0 0.54743083 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Non-homologous end-joining -0.606086957 -0.721343874 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Notch signaling pathway 0 0 -0.454568855 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Nucleotide excision repair -0.725217391 -0.579051383 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway One carbon pool by folate -0.688695652 -0.610671937 -0.486486486 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Oocyte meiosis -0.486956522 -0.635375494 -0.482882883 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Other glycan degradation 0 0 -0.622651223 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Ovarian steroidogenesis 0 0 0.477477477 kegg kegg NA NA no no no no up up Adipocytokine signaling pathway Paraprevotella 0 -0.428393477 0 kegg Genus NA 0.118 no no no no no no Adipocytokine signaling pathway Pentose and glucuronate interconversions -0.577391304 -0.621541502 -0.667696268 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Phenylalanine metabolism 0 -0.761857708 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Phospholipase D signaling pathway 0 0.600790514 0 kegg kegg NA NA no no no no up up Adipocytokine signaling pathway Phototransduction 0 -0.604743083 -0.462548263 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Platelet activation 0 -0.522727273 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Platinum drug resistance -0.405217391 0 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Porphyrin and chlorophyll metabolism 0 0 0.758558559 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway PPAR signaling pathway 0 0.589920949 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Primary bile acid biosynthesis -0.726956522 -0.608695652 -0.427284427 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Progesterone-mediated oocyte maturation 0 0 -0.543886744 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Prolactin signaling pathway 0 0.484189723 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Propanoate metabolism -0.620869565 -0.670948617 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Proteasome 0 -0.529644269 -0.402831403 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Protein export 0 -0.446640316 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Purine metabolism 0 0 0.745173745 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Pyrimidine metabolism -0.417391304 -0.541501976 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Pyruvate metabolism -0.645217391 -0.604743083 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Ras signaling pathway 0 -0.596837945 0 yes kegg kegg NA NA no no no no up up Adipocytokine signaling pathway Regulation of actin cytoskeleton 0 -0.638339921 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Retinol metabolism -0.642608696 -0.630434783 -0.634234234 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Retrograde endocannabinoid signaling 0 0 -0.523552124 kegg kegg NA NA no no no no no up Adipocytokine signaling pathway Ribosome biogenesis in eukaryotes -0.46 -0.419960474 -0.464350064 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway RIG-I-like receptor signaling pathway 0 0.747035573 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway RNA degradation 0 -0.416007905 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway RNA polymerase 0 -0.414031621 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Selenocompound metabolism 0 0 -0.476447876 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Serotonergic synapse 0 0 0.406435006 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway SNARE interactions in vesicular transport 0 0 -0.413642214 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Sphingolipid metabolism 0.431304348 0 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Sphingolipid signaling pathway 0 0 -0.448906049 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Steroid biosynthesis -0.406086957 -0.685770751 -0.506048906 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Steroid hormone biosynthesis -0.424347826 -0.709486166 -0.478507079 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Sulfur metabolism 0 0 0.548777349 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Synthesis and degradation of ketone bodies -0.780869565 -0.524703557 -0.505534106 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway T cell receptor signaling pathway 0 0.527667984 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Taste transduction -0.606956522 -0.480237154 -0.472329472 kegg kegg NA NA no no no no no up Adipocytokine signaling pathway Taurine and hypotaurine metabolism 0 0.455533597 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Terpenoid backbone biosynthesis -0.531304348 0 -0.408751609 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway TGF-beta signaling pathway 0 -0.5 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Th1 and Th2 cell differentiation 0.41826087 0 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Thyroid hormone signaling pathway 0 -0.445652174 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Thyroid hormone synthesis 0 0 0.550579151 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Tight junction 0 -0.497035573 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway TNF signaling pathway 0.523478261 0.72826087 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Toll-like receptor signaling pathway 0 0.637351779 0 yes kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Tryptophan metabolism -0.509565217 -0.783596838 -0.447361647 kegg kegg NA NA no no no no up no Adipocytokine signaling pathway Tyrosine metabolism -0.519130435 -0.734189723 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.553043478 -0.651185771 0 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Ubiquitin mediated proteolysis 0.500869565 0 0.616988417 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway "Valine, leucine and isoleucine degradation" -0.589565217 -0.691699605 -0.570656371 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Various types of N-glycan biosynthesis 0 -0.431818182 -0.523809524 kegg kegg NA NA no no no no no no Adipocytokine signaling pathway Wnt signaling pathway 0 -0.484189723 -0.41003861 kegg kegg NA NA no no no no no no Adrenergic signaling in cardiomyocytes 2-Oxocarboxylic acid metabolism -0.586956522 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes ABC transporters -0.736521739 0 0 kegg kegg NA NA no no up no up up Adrenergic signaling in cardiomyocytes "Alanine, aspartate and glutamate metabolism" -0.48 -0.690711462 -0.546203346 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes alpha-Linolenic acid metabolism -0.766086957 -0.760869565 -0.568339768 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Amino sugar and nucleotide sugar metabolism -0.692173913 0 -0.545688546 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Aminoacyl-tRNA biosynthesis -0.628695652 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes AMPK signaling pathway 0 0.64229249 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Apoptosis -0.504347826 -0.545454545 -0.515830116 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Arginine and proline metabolism -0.473043478 -0.640316206 -0.450707851 kegg kegg NA NA no no up no up no Adrenergic signaling in cardiomyocytes Arginine biosynthesis -0.503478261 -0.639328063 -0.523294723 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Ascorbate and aldarate metabolism -0.442608696 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Autophagy - animal 0 -0.508893281 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes beta-Alanine metabolism -0.783478261 0 -0.463320463 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Biosynthesis of amino acids -0.677391304 -0.669960474 -0.647619048 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Biosynthesis of cofactors 0 0.462450593 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Biosynthesis of unsaturated fatty acids -0.471304348 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Butanoate metabolism -0.666086957 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Butyricimonas 0.549552113 0 0 butyrate-producing kegg Genus NA 0.17 no no up no no no Adrenergic signaling in cardiomyocytes Calcium signaling pathway 0.857391304 0.798418972 0.83963964 kegg kegg NA NA no no up no up up Adrenergic signaling in cardiomyocytes cAMP signaling pathway 0.832173913 0 0.550836551 yes kegg kegg NA NA no no up no up up Adrenergic signaling in cardiomyocytes Carbon metabolism -0.654782609 0 -0.655855856 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Cardiac muscle contraction 0.729565217 0.779644269 0.458944659 kegg kegg NA NA no no up no no up Adrenergic signaling in cardiomyocytes Cell cycle 0 0.453557312 0.492921493 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Cellular senescence 0 -0.455533597 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes cGMP-PKG signaling pathway 0 -0.657114625 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Chemokine signaling pathway 0 -0.47826087 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Citrate cycle (TCA cycle) -0.425217391 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Clostridium -0.426969045 0 0 kegg Genus NA 0.925 no no up no no no Adrenergic signaling in cardiomyocytes Cytokine-cytokine receptor interaction 0 -0.565217391 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Drug metabolism - other enzymes -0.589565217 0 -0.526383526 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes EGFR tyrosine kinase inhibitor resistance 0 0.613636364 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Endocrine resistance 0.635652174 0 0.557528958 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Endocytosis 0 -0.530632411 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Ether lipid metabolism 0.430434783 0.520750988 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Fatty acid biosynthesis 0 -0.748023715 -0.502187902 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Fatty acid degradation -0.677391304 -0.703557312 -0.648133848 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Fatty acid elongation -0.567826087 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Fatty acid metabolism -0.766956522 -0.766798419 -0.58018018 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Ferroptosis 0.42 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Folate biosynthesis 0 0.447628458 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes FoxO signaling pathway 0 -0.580039526 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Fructose and mannose metabolism -0.836521739 0 -0.695238095 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Galactose metabolism -0.910434783 -0.781620553 -0.539253539 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Glutathione metabolism 0 0.632411067 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Glycerolipid metabolism -0.622608696 -0.433794466 0 kegg kegg NA NA no no up no no up Adrenergic signaling in cardiomyocytes "Glycine, serine and threonine metabolism" 0 0.469367589 0 kegg kegg NA NA no no up no up no Adrenergic signaling in cardiomyocytes Glycolysis / Gluconeogenesis -0.568695652 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.472332016 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Glycosaminoglycan biosynthesis - keratan sulfate 0.506086957 0.451581028 0.485199485 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Glycosaminoglycan degradation 0 -0.499011858 0 kegg kegg NA NA no no up no no up Adrenergic signaling in cardiomyocytes Glyoxylate and dicarboxylate metabolism -0.686086957 -0.65513834 -0.588931789 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes HIF-1 signaling pathway 0 0.485177866 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Histidine metabolism -0.730434783 0 -0.635521236 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Inositol phosphate metabolism -0.508695652 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Longevity regulating pathway - multiple species 0 -0.491106719 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Lysosome 0 -0.522727273 -0.646846847 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes MAPK signaling pathway 0 -0.498023715 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Mitophagy - animal 0.624347826 0.716403162 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes mRNA surveillance pathway 0.589565217 0.766798419 0.588159588 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes mTOR signaling pathway 0 0.606719368 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes N-Glycan biosynthesis 0 0.586956522 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Necroptosis 0.537391304 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Neuroactive ligand-receptor interaction 0 -0.639328063 -0.494723295 kegg kegg NA NA no no up up up up Adrenergic signaling in cardiomyocytes NF-kappa B signaling pathway -0.447826087 -0.529644269 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Nicotinate and nicotinamide metabolism -0.405217391 -0.673913043 -0.559073359 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Nitrogen metabolism 0 -0.509881423 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Non-homologous end-joining -0.566086957 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Oocyte meiosis 0.483478261 0 0.558301158 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Oscillospira 0 0 -0.441698842 LPS-producing kegg Genus NA 0.62 no no up no no no Adrenergic signaling in cardiomyocytes Other glycan degradation -0.612173913 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Oxidative phosphorylation 0.713043478 0.793478261 0.401544402 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Pantothenate and CoA biosynthesis 0 -0.833003953 -0.665894466 kegg kegg NA NA no no up no no dn Adrenergic signaling in cardiomyocytes Pentose and glucuronate interconversions 0 0.428853755 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Pentose phosphate pathway -0.509565217 -0.675889328 -0.703989704 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Peroxisome -0.596521739 -0.842885375 -0.583268983 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Phagosome 0 -0.593873518 -0.415186615 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Phenylalanine metabolism -0.41826087 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Phosphatidylinositol signaling system 0.553043478 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes PPAR signaling pathway 0 -0.56916996 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Prevotella 0 0 0.433147007 acetate-producing kegg Genus NA 0.287 no no up no no no Adrenergic signaling in cardiomyocytes Primary bile acid biosynthesis -0.505217391 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Protein export 0.500869565 0.646245059 0.476962677 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Protein processing in endoplasmic reticulum 0 0.66798419 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Purine metabolism 0 0.48715415 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Pyrimidine metabolism -0.723478261 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Ras signaling pathway 0.482608696 0.596837945 0.463577864 yes kegg kegg NA NA no no up no up up Adrenergic signaling in cardiomyocytes Retinol metabolism -0.443478261 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Ribosome 0.599130435 0.706521739 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes RNA degradation 0.55826087 0.68083004 0.418532819 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes RNA polymerase 0 0.516798419 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes RNA transport 0 0.501976285 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes SNARE interactions in vesicular transport -0.53826087 -0.453557312 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Sphingolipid metabolism 0 0 -0.413127413 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Sphingolipid signaling pathway 0.559130435 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Spliceosome 0 0 0.408751609 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Starch and sucrose metabolism -0.689565217 -0.801383399 -0.723809524 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Thiamine metabolism -0.443478261 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Tryptophan metabolism -0.7 0 0 kegg kegg NA NA no no up no up no Adrenergic signaling in cardiomyocytes Ubiquinone and other terpenoid-quinone biosynthesis -0.635652174 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Ubiquitin mediated proteolysis 0.610434783 0.751976285 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes "Valine, leucine and isoleucine degradation" -0.597391304 0 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Various types of N-glycan biosynthesis 0 0.443675889 0 kegg kegg NA NA no no up no no no Adrenergic signaling in cardiomyocytes Viral protein interaction with cytokine and cytokine receptor 0.462608696 0 0 kegg kegg NA NA no no up no no no African trypanosomiasis 2-Oxocarboxylic acid metabolism -0.553043478 -0.484189723 0 kegg kegg NA NA no no no no no no African trypanosomiasis ABC transporters 0 0.436758893 0 kegg kegg NA NA no no no no up up African trypanosomiasis Adrenergic signaling in cardiomyocytes 0 -0.561264822 -0.546718147 kegg kegg NA NA no no no no no up African trypanosomiasis AGE-RAGE signaling pathway in diabetic complications 0 0.606719368 0 kegg kegg NA NA no no no no no no African trypanosomiasis "Alanine, aspartate and glutamate metabolism" 0 0.555335968 0 kegg kegg NA NA no no no no no no African trypanosomiasis Aldosterone synthesis and secretion 0 0 -0.431660232 kegg kegg NA NA no no no no up up African trypanosomiasis alpha-Linolenic acid metabolism 0 0.746047431 0 kegg kegg NA NA no no no no no no African trypanosomiasis Alzheimer disease 0 -0.482213439 0 kegg kegg NA NA no no no no no no African trypanosomiasis Amphetamine addiction 0 -0.462450593 -0.454311454 kegg kegg NA NA no no no no no no African trypanosomiasis Amyotrophic lateral sclerosis 0 -0.480237154 0 kegg kegg NA NA no no no no no no African trypanosomiasis Apelin signaling pathway 0 -0.722332016 0 kegg kegg NA NA no no no no no no African trypanosomiasis Apoptosis 0 0.516798419 0 kegg kegg NA NA no no no no no no African trypanosomiasis Arginine biosynthesis 0 0.566205534 0 kegg kegg NA NA no no no no no no African trypanosomiasis Autophagy - animal 0 0.458498024 0 kegg kegg NA NA no no no no no no African trypanosomiasis Axon guidance 0 0 -0.414157014 kegg kegg NA NA no no no no up up African trypanosomiasis B cell receptor signaling pathway 0 0.436758893 0.421364221 kegg kegg NA NA no no no no no no African trypanosomiasis Butanoate metabolism -0.423478261 -0.540513834 0 kegg kegg NA NA no no no no no no African trypanosomiasis C-type lectin receptor signaling pathway 0.484347826 0.520750988 0 kegg kegg NA NA no no no no no no African trypanosomiasis Carbohydrate digestion and absorption 0 0.453557312 0 kegg kegg NA NA no no no no no no African trypanosomiasis Carbon metabolism -0.444347826 0 0 kegg kegg NA NA no no no no no no African trypanosomiasis Cellular senescence 0 0.459486166 0 kegg kegg NA NA no no no no no no African trypanosomiasis cGMP-PKG signaling pathway 0.466956522 0 0 kegg kegg NA NA no no no no no no African trypanosomiasis Chagas disease 0 0.561264822 0 kegg kegg NA NA no no no no no no African trypanosomiasis Chemokine signaling pathway 0 0.471343874 0 kegg kegg NA NA no no no no no no African trypanosomiasis Citrate cycle (TCA cycle) -0.533043478 -0.568181818 0 kegg kegg NA NA no no no no no no African trypanosomiasis Complement and coagulation cascades 0 0.529644269 0 kegg kegg NA NA no no no no no no African trypanosomiasis Cysteine and methionine metabolism 0 -0.58201581 0 kegg kegg NA NA no no no no no no African trypanosomiasis DNA replication 0 -0.476284585 0 kegg kegg NA NA no no no no no no African trypanosomiasis Dopaminergic synapse 0 -0.472332016 -0.442471042 kegg kegg NA NA no no no no up no African trypanosomiasis Drug metabolism - cytochrome P450 0 -0.595849802 0 kegg kegg NA NA no no no no no no African trypanosomiasis Drug metabolism - other enzymes -0.407826087 -0.636363636 0.421621622 kegg kegg NA NA no no no no no no African trypanosomiasis ECM-receptor interaction 0 -0.459486166 -0.522779923 kegg kegg NA NA no no no no up up African trypanosomiasis EGFR tyrosine kinase inhibitor resistance 0 -0.716403162 0 kegg kegg NA NA no no no no no no African trypanosomiasis Epithelial cell signaling in Helicobacter pylori infection 0 0.508893281 0 kegg kegg NA NA no no no no no no African trypanosomiasis ErbB signaling pathway 0.427826087 0 0 kegg kegg NA NA no no no no no no African trypanosomiasis Estrogen signaling pathway 0 0 -0.476447876 kegg kegg NA NA no no no no no no African trypanosomiasis Fat digestion and absorption 0 0.556324111 0.548005148 yes kegg kegg NA NA no no no no up up African trypanosomiasis Fatty acid biosynthesis 0 0.603754941 0 kegg kegg NA NA no no no no no no African trypanosomiasis Fc epsilon RI signaling pathway 0.482608696 0.62055336 0 kegg kegg NA NA no no no no no no African trypanosomiasis Fc gamma R-mediated phagocytosis 0 0.497035573 0 kegg kegg NA NA no no no no no no African trypanosomiasis Folate biosynthesis 0 -0.581027668 0 kegg kegg NA NA no no no no no no African trypanosomiasis FoxO signaling pathway 0 0.553359684 0 kegg kegg NA NA no no no no no no African trypanosomiasis Fructose and mannose metabolism 0 0 0.561904762 kegg kegg NA NA no no no no no no African trypanosomiasis GABAergic synapse 0 0.431818182 0 kegg kegg NA NA no no no no up up African trypanosomiasis Galactose metabolism 0 0.631422925 0.417503218 kegg kegg NA NA no no no no no no African trypanosomiasis Glucagon signaling pathway 0 -0.420948617 -0.514028314 kegg kegg NA NA no no no no no no African trypanosomiasis Glutamatergic synapse 0 0.414031621 0 kegg kegg NA NA no no no no up up African trypanosomiasis Glutathione metabolism 0 -0.632411067 0 kegg kegg NA NA no no no no no no African trypanosomiasis Glycerolipid metabolism 0 0.450592885 0 kegg kegg NA NA no no no no no up African trypanosomiasis Glycolysis / Gluconeogenesis -0.503478261 -0.503952569 0 kegg kegg NA NA no no no no no no African trypanosomiasis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.566205534 0 kegg kegg NA NA no no no no no no African trypanosomiasis Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.422608696 0 0 kegg kegg NA NA no no no no no no African trypanosomiasis Glycosphingolipid biosynthesis - globo and isoglobo series 0 -0.416007905 0 kegg kegg NA NA no no no no no no African trypanosomiasis Glyoxylate and dicarboxylate metabolism 0 0.522727273 0 kegg kegg NA NA no no no no no no African trypanosomiasis GnRH secretion 0.523478261 0 0 kegg kegg NA NA no no no no up up African trypanosomiasis GnRH signaling pathway 0 0 -0.414671815 kegg kegg NA NA no no no no no no African trypanosomiasis HIF-1 signaling pathway 0 -0.692687747 0 kegg kegg NA NA no no no no no no African trypanosomiasis Hippo signaling pathway - multiple species 0 0.421936759 0 kegg kegg NA NA no no no no no no African trypanosomiasis Huntington disease 0 -0.457509881 0 kegg kegg NA NA no no no no no no African trypanosomiasis IL-17 signaling pathway 0 0.462450593 0 kegg kegg NA NA no no no no no no African trypanosomiasis Inflammatory mediator regulation of TRP channels 0 0 -0.472586873 kegg kegg NA NA no no no no no no African trypanosomiasis Insulin resistance 0.473043478 0.509881423 0 kegg kegg NA NA no no no no no no African trypanosomiasis Insulin signaling pathway 0 -0.739130435 0 kegg kegg NA NA no no no no no no African trypanosomiasis JAK-STAT signaling pathway 0.447826087 0.613636364 0 kegg kegg NA NA no no no no no no African trypanosomiasis Legionellosis 0 -0.529644269 0 kegg kegg NA NA no no no no no no African trypanosomiasis Leishmaniasis 0 -0.483201581 0 kegg kegg NA NA no no no no no no African trypanosomiasis Long-term potentiation 0 -0.545454545 0 kegg kegg NA NA no no no no no up African trypanosomiasis Lysosome 0 0 0.441441441 kegg kegg NA NA no no no no no no African trypanosomiasis Melanogenesis 0 0 -0.527927928 kegg kegg NA NA no no no no no no African trypanosomiasis Metabolism of xenobiotics by cytochrome P450 0 -0.559288538 0 kegg kegg NA NA no no no no no no African trypanosomiasis Mismatch repair 0 -0.424901186 0 kegg kegg NA NA no no no no no no African trypanosomiasis mRNA surveillance pathway 0 -0.59486166 0 kegg kegg NA NA no no no no no no African trypanosomiasis mTOR signaling pathway 0 -0.736166008 0 kegg kegg NA NA no no no no no no African trypanosomiasis Mucin type O-glycan biosynthesis 0 0 -0.426512227 kegg kegg NA NA no no no no no no African trypanosomiasis N-Glycan biosynthesis 0 -0.653162055 0 kegg kegg NA NA no no no no no no African trypanosomiasis Natural killer cell mediated cytotoxicity 0 0.415019763 0 kegg kegg NA NA no no no no no no African trypanosomiasis Neutrophil extracellular trap formation 0 0.558300395 0 kegg kegg NA NA no no no no no no African trypanosomiasis NF-kappa B signaling pathway 0 0.548418972 0 kegg kegg NA NA no no no no no no African trypanosomiasis Nicotinate and nicotinamide metabolism 0 0.631422925 0 kegg kegg NA NA no no no no no no African trypanosomiasis Nitrogen metabolism 0 0.48715415 0 kegg kegg NA NA no no no no no no African trypanosomiasis NOD-like receptor signaling pathway 0 0.505928854 0 kegg kegg NA NA no no no no no no African trypanosomiasis Non-homologous end-joining -0.455652174 -0.418972332 0 kegg kegg NA NA no no no no no no African trypanosomiasis Notch signaling pathway 0.54 0 0 kegg kegg NA NA no no no no no no African trypanosomiasis Olfactory transduction 0 0.434782609 0 kegg kegg NA NA no no no no no no African trypanosomiasis Oocyte meiosis 0 -0.564229249 -0.411325611 kegg kegg NA NA no no no no no no African trypanosomiasis Osteoclast differentiation 0 0.623517787 0 kegg kegg NA NA no no no no no no African trypanosomiasis Oxidative phosphorylation 0 -0.441699605 0 kegg kegg NA NA no no no no no no African trypanosomiasis Pantothenate and CoA biosynthesis 0 0.633399209 0 kegg kegg NA NA no no no no no dn African trypanosomiasis "Parathyroid hormone synthesis, secretion and action" 0 -0.457509881 0 kegg kegg NA NA no no no no no no African trypanosomiasis Pentose and glucuronate interconversions -0.432173913 -0.600790514 0 kegg kegg NA NA no no no no no no African trypanosomiasis Pentose phosphate pathway 0 0.433794466 0 kegg kegg NA NA no no no no no no African trypanosomiasis Peroxisome 0 0.583003953 0 kegg kegg NA NA no no no no no no African trypanosomiasis Phenylalanine metabolism -0.43826087 0 0 kegg kegg NA NA no no no no no no African trypanosomiasis Phospholipase D signaling pathway 0 0.601778656 0 kegg kegg NA NA no no no no up up African trypanosomiasis PI3K-Akt signaling pathway 0 -0.41798419 0 yes kegg kegg NA NA no no no no up up African trypanosomiasis Prion disease 0 -0.530632411 0 kegg kegg NA NA no no no no no no African trypanosomiasis Prolactin signaling pathway 0.436521739 0.657114625 0 kegg kegg NA NA no no no no no no African trypanosomiasis Propanoate metabolism 0 -0.577075099 0 kegg kegg NA NA no no no no no no African trypanosomiasis Proteasome 0 -0.490118577 0 kegg kegg NA NA no no no no no no African trypanosomiasis Protein export 0 -0.727272727 0 kegg kegg NA NA no no no no no no African trypanosomiasis Protein processing in endoplasmic reticulum 0 -0.727272727 0 kegg kegg NA NA no no no no no no African trypanosomiasis Proximal tubule bicarbonate reclamation 0 -0.62055336 -0.413642214 kegg kegg NA NA no no no no no no African trypanosomiasis Pyruvate metabolism 0 -0.644268775 0 kegg kegg NA NA no no no no no no African trypanosomiasis Ras signaling pathway 0 -0.589920949 0 yes kegg kegg NA NA no no no no up up African trypanosomiasis Renin secretion 0 0 -0.485714286 kegg kegg NA NA no no no no no no African trypanosomiasis Retrograde endocannabinoid signaling 0 -0.493083004 0 kegg kegg NA NA no no no no no up African trypanosomiasis Ribosome 0 -0.599802372 0 kegg kegg NA NA no no no no no no African trypanosomiasis RIG-I-like receptor signaling pathway 0 0.477272727 0 kegg kegg NA NA no no no no no no African trypanosomiasis RNA degradation 0 -0.697628458 0 kegg kegg NA NA no no no no no no African trypanosomiasis RNA polymerase 0 -0.431818182 0 kegg kegg NA NA no no no no no no African trypanosomiasis RNA transport 0 -0.735177866 0 kegg kegg NA NA no no no no no no African trypanosomiasis Sphingolipid signaling pathway 0.443478261 0 0 kegg kegg NA NA no no no no no no African trypanosomiasis Starch and sucrose metabolism 0 0.631422925 0.5997426 kegg kegg NA NA no no no no no no African trypanosomiasis Synaptic vesicle cycle 0 0.42687747 0.590733591 kegg kegg NA NA no no no no up up African trypanosomiasis Taurine and hypotaurine metabolism 0.430434783 0.422924901 0 kegg kegg NA NA no no no no no no African trypanosomiasis TGF-beta signaling pathway 0 -0.647233202 0 kegg kegg NA NA no no no no no no African trypanosomiasis Thermogenesis 0 -0.494071146 0 kegg kegg NA NA no no no no no no African trypanosomiasis Thiamine metabolism 0 -0.636363636 0 kegg kegg NA NA no no no no no no African trypanosomiasis TNF signaling pathway 0 0.440711462 0 kegg kegg NA NA no no no no no no African trypanosomiasis Toll-like receptor signaling pathway 0 0.515810277 0 yes kegg kegg NA NA no no no no no no African trypanosomiasis Type II diabetes mellitus 0.450434783 0.420948617 0 kegg kegg NA NA no no no no no no African trypanosomiasis Tyrosine metabolism -0.440869565 -0.416996047 0 kegg kegg NA NA no no no no no no African trypanosomiasis "Valine, leucine and isoleucine degradation" 0 -0.494071146 0 kegg kegg NA NA no no no no no no African trypanosomiasis Various types of N-glycan biosynthesis 0 -0.609683794 0 kegg kegg NA NA no no no no no no African trypanosomiasis Vasopressin-regulated water reabsorption 0 0 -0.40978121 kegg kegg NA NA no no no no no no African trypanosomiasis VEGF signaling pathway 0.499130435 0 0 kegg kegg NA NA no no no no no no African trypanosomiasis Wnt signaling pathway 0 -0.551383399 0 kegg kegg NA NA no no no no no no African trypanosomiasis Yersinia infection 0 0.441699605 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications 2-Oxocarboxylic acid metabolism 0 -0.664031621 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Adherens junction 0 -0.600790514 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Adipocytokine signaling pathway 0 0.418972332 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Adrenergic signaling in cardiomyocytes 0 -0.734189723 0 kegg kegg NA NA no no no no no up AGE-RAGE signaling pathway in diabetic complications "Alanine, aspartate and glutamate metabolism" 0.470434783 0.847826087 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Aldosterone synthesis and secretion 0 -0.677865613 0 kegg kegg NA NA no no no no up up AGE-RAGE signaling pathway in diabetic complications alpha-Linolenic acid metabolism 0 0.643280632 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Aminoacyl-tRNA biosynthesis 0 -0.449604743 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Apelin signaling pathway 0 -0.799407115 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Apoptosis 0 0.725296443 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Apoptosis - multiple species 0.546086957 0 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Arachidonic acid metabolism -0.462608696 0 -0.494208494 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Arginine and proline metabolism 0 0.85770751 0 kegg kegg NA NA no no no no up no AGE-RAGE signaling pathway in diabetic complications Arginine biosynthesis 0.415652174 0.824110672 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Ascorbate and aldarate metabolism 0 -0.448616601 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Autophagy - animal 0.432173913 0.800395257 0.604890605 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Autophagy - other 0 0 0.415444015 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications B cell receptor signaling pathway 0 0.751976285 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Bacteroides 0.451304348 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up AGE-RAGE signaling pathway in diabetic complications Basal transcription factors 0 -0.434782609 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Biosynthesis of amino acids 0 0.657114625 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Biosynthesis of cofactors -0.46 -0.47826087 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Butanoate metabolism 0 -0.705533597 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications C-type lectin receptor signaling pathway 0 0.77173913 0.550579151 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Calcium signaling pathway 0 -0.51284585 0 kegg kegg NA NA no no no no up up AGE-RAGE signaling pathway in diabetic complications Cardiac muscle contraction 0 -0.782608696 0 kegg kegg NA NA no no no no no up AGE-RAGE signaling pathway in diabetic complications Cell cycle 0 -0.566205534 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Cellular senescence 0 0.496047431 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications cGMP-PKG signaling pathway 0 0.76284585 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Chemokine signaling pathway 0 0.729249012 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Cholinergic synapse 0 0.436758893 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Circadian entrainment 0 -0.52173913 0 kegg kegg NA NA no no no no up up AGE-RAGE signaling pathway in diabetic complications Citrate cycle (TCA cycle) 0 -0.748023715 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Collinsella 0 0 -0.441821015 kegg Genus NA 0.128 no no no no no no AGE-RAGE signaling pathway in diabetic complications Complement and coagulation cascades 0 0.712450593 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Cysteine and methionine metabolism 0 -0.679841897 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications DNA replication 0 -0.734189723 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Dopaminergic synapse 0 -0.625494071 0 kegg kegg NA NA no no no no up no AGE-RAGE signaling pathway in diabetic complications Drug metabolism - cytochrome P450 -0.524347826 -0.787549407 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Drug metabolism - other enzymes 0 -0.783596838 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications EGFR tyrosine kinase inhibitor resistance 0 -0.677865613 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Endocytosis 0 0.458498024 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications ErbB signaling pathway 0.616521739 0.530632411 0.641956242 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Estrogen signaling pathway 0 -0.617588933 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Ether lipid metabolism 0 -0.520750988 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Fatty acid biosynthesis 0.54 0.874505929 0.487516088 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Fatty acid degradation 0 0.630434783 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Fatty acid metabolism 0 0.634387352 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Fc epsilon RI signaling pathway 0.57826087 0.846837945 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Fc gamma R-mediated phagocytosis 0 0.696640316 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Focal adhesion 0 -0.570158103 0 kegg kegg NA NA no no no no up up AGE-RAGE signaling pathway in diabetic complications Folate biosynthesis -0.517391304 -0.522727273 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications FoxO signaling pathway 0.491304348 0.670948617 0.437065637 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Fructose and mannose metabolism 0 0.504940711 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications GABAergic synapse 0.476521739 0.743083004 0 kegg kegg NA NA no no no no up up AGE-RAGE signaling pathway in diabetic complications Galactose metabolism 0 0.648221344 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Glucagon signaling pathway 0 -0.749011858 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Glutathione metabolism -0.435652174 -0.602766798 -0.430888031 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Glycerolipid metabolism 0 0.476284585 0 kegg kegg NA NA no no no no no up AGE-RAGE signaling pathway in diabetic complications Glycolysis / Gluconeogenesis 0 -0.584980237 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.46173913 0.7756917 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Glycosphingolipid biosynthesis - ganglio series 0 -0.436758893 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Glycosphingolipid biosynthesis - globo and isoglobo series -0.439130435 0 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Glyoxylate and dicarboxylate metabolism 0.414782609 0.833003953 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications GnRH secretion 0.553043478 0.553359684 0.505534106 kegg kegg NA NA no no no no up up AGE-RAGE signaling pathway in diabetic complications HIF-1 signaling pathway 0 -0.65513834 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Hippo signaling pathway 0 -0.665019763 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Hippo signaling pathway - multiple species 0 0.743083004 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications IL-17 signaling pathway 0 0.685770751 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Inflammatory mediator regulation of TRP channels 0 -0.747035573 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Insulin resistance 0 0.673913043 0.457400257 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Insulin signaling pathway 0 -0.725296443 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Intestinal immune network for IgA production 0.460869565 0 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications JAK-STAT signaling pathway 0 0.75 0.422908623 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Linoleic acid metabolism -0.746956522 0 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Long-term potentiation 0 -0.538537549 0 kegg kegg NA NA no no no no no up AGE-RAGE signaling pathway in diabetic complications Lysosome 0 0.475296443 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications MAPK signaling pathway 0 0 0.443758044 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Melanogenesis 0 -0.758893281 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Metabolism of xenobiotics by cytochrome P450 -0.43826087 -0.761857708 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Mismatch repair 0 -0.513833992 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Mitophagy - animal 0 -0.572134387 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications mRNA surveillance pathway 0 -0.713438735 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications mTOR signaling pathway 0 -0.666996047 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications N-Glycan biosynthesis 0 -0.787549407 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Natural killer cell mediated cytotoxicity 0 0.443675889 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Neuroactive ligand-receptor interaction 0 0.510869565 0 kegg kegg NA NA no no no up up up AGE-RAGE signaling pathway in diabetic complications Neurotrophin signaling pathway 0 0.556324111 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Neutrophil extracellular trap formation 0 0.665019763 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications NF-kappa B signaling pathway 0.528695652 0.792490119 0.621106821 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Nicotinate and nicotinamide metabolism 0.423478261 0.89229249 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Nitrogen metabolism 0 0.78458498 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications NOD-like receptor signaling pathway 0 0.79743083 0.52046332 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Non-alcoholic fatty liver disease 0 -0.739130435 -0.435521236 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Notch signaling pathway 0.426956522 0 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Nucleotide excision repair 0 -0.586956522 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Olfactory transduction 0 0.649209486 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications One carbon pool by folate 0 -0.555335968 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Oocyte meiosis 0 -0.62944664 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Osteoclast differentiation 0 0.833003953 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Oxidative phosphorylation 0 -0.796442688 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Pantothenate and CoA biosynthesis 0.416521739 0.829051383 0 kegg kegg NA NA no no no no no dn AGE-RAGE signaling pathway in diabetic complications "Parathyroid hormone synthesis, secretion and action" 0 -0.62055336 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Pentose and glucuronate interconversions -0.604347826 -0.826086957 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Pentose phosphate pathway 0 0.636363636 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Peroxisome 0.425217391 0.713438735 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Phagosome 0 0.451581028 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Phenylalanine metabolism 0 -0.590909091 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Phospholipase D signaling pathway 0.566956522 0.709486166 0 kegg kegg NA NA no no no no up up AGE-RAGE signaling pathway in diabetic complications Phototransduction 0 -0.609683794 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Platelet activation 0 -0.479249012 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Platinum drug resistance 0.496521739 0 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications PPAR signaling pathway 0 0.691699605 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Prolactin signaling pathway 0.557391304 0.82312253 0.616216216 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Propanoate metabolism 0 -0.635375494 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Proteasome 0 -0.657114625 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Protein export 0 -0.827075099 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Protein processing in endoplasmic reticulum 0 -0.81916996 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Pyrimidine metabolism 0 -0.530632411 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Pyruvate metabolism 0 -0.756916996 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Ras signaling pathway 0 -0.668972332 0 yes kegg kegg NA NA no no no no up up AGE-RAGE signaling pathway in diabetic complications Regulation of actin cytoskeleton -0.493913043 -0.422924901 -0.45997426 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Relaxin signaling pathway 0 0.431818182 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Renin secretion -0.423478261 -0.759881423 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Renin-angiotensin system 0 0.637351779 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Retrograde endocannabinoid signaling -0.408695652 -0.774703557 0 kegg kegg NA NA no no no no no up AGE-RAGE signaling pathway in diabetic complications Ribosome 0 -0.78458498 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Ribosome biogenesis in eukaryotes 0 -0.53458498 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications RIG-I-like receptor signaling pathway 0 0.799407115 0.504247104 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications RNA degradation 0 -0.793478261 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications RNA polymerase 0 -0.710474308 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications RNA transport 0 -0.644268775 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Signaling pathways regulating pluripotency of stem cells 0 0 0.449420849 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications SNARE interactions in vesicular transport 0 0.484189723 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Sphingolipid signaling pathway 0 0.470355731 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Starch and sucrose metabolism 0 0.790513834 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Steroid biosynthesis 0 -0.469367589 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Steroid hormone biosynthesis -0.483478261 0 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Synaptic vesicle cycle 0 0.636363636 0 kegg kegg NA NA no no no no up up AGE-RAGE signaling pathway in diabetic complications Synthesis and degradation of ketone bodies 0 -0.52173913 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications T cell receptor signaling pathway 0 0.416007905 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Taste transduction 0 -0.490118577 0 kegg kegg NA NA no no no no no up AGE-RAGE signaling pathway in diabetic complications TGF-beta signaling pathway 0 -0.732213439 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Thermogenesis 0 -0.847826087 -0.483397683 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Thiamine metabolism 0 -0.59486166 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Thyroid hormone signaling pathway 0 -0.53458498 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Thyroid hormone synthesis 0 -0.451581028 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Tight junction -0.430434783 -0.494071146 -0.43989704 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications TNF signaling pathway 0 0.684782609 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Toll-like receptor signaling pathway 0 0.828063241 0 yes kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Tryptophan metabolism 0 -0.485177866 0 kegg kegg NA NA no no no no up no AGE-RAGE signaling pathway in diabetic complications Type II diabetes mellitus 0 0.739130435 0.592792793 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Tyrosine metabolism 0 -0.571146245 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.503952569 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Ubiquitin mediated proteolysis 0 -0.663043478 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications "Valine, leucine and isoleucine degradation" 0 -0.669960474 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Various types of N-glycan biosynthesis 0 -0.65513834 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Vascular smooth muscle contraction 0 -0.711462451 0 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications VEGF signaling pathway 0.53826087 0.66798419 0.405148005 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Viral protein interaction with cytokine and cytokine receptor 0 0 -0.517117117 kegg kegg NA NA no no no no no no AGE-RAGE signaling pathway in diabetic complications Wnt signaling pathway 0 -0.780632411 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Arginine biosynthesis 0.980869565 0.97826087 0.968854569 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Ascorbate and aldarate metabolism 0 -0.441699605 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Citrate cycle (TCA cycle) 0 -0.649209486 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Fatty acid biosynthesis 0.897391304 0.95256917 0.792792793 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Fatty acid degradation 0.706086957 0.778656126 0.495238095 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Galactose metabolism 0 0.581027668 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Glycolysis / Gluconeogenesis 0 -0.511857708 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Oxidative phosphorylation -0.543478261 -0.768774704 -0.511196911 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Pentose and glucuronate interconversions -0.436521739 -0.809288538 -0.577348777 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Pentose phosphate pathway 0.413043478 0.588932806 0.693951094 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Pyrimidine metabolism 0 -0.634387352 0 kegg kegg NA NA no no no no no no "Alanine, aspartate and glutamate metabolism" Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.444664032 0 kegg kegg NA NA no no no no no no Alcoholism 2-Oxocarboxylic acid metabolism -0.54173913 -0.522727273 -0.49009009 kegg kegg NA NA no no no no no no Alcoholism ABC transporters -0.489565217 0 -0.508622909 kegg kegg NA NA no no no no up up Alcoholism Adrenergic signaling in cardiomyocytes 0.510434783 0 0.414929215 kegg kegg NA NA no no no no no up Alcoholism Aldosterone synthesis and secretion 0 0 0.479279279 kegg kegg NA NA no no no no up up Alcoholism Alistipes 0 -0.447252486 0 kegg Genus NA 0.0114 no no no no up no Alcoholism alpha-Linolenic acid metabolism -0.625217391 0 -0.469240669 kegg kegg NA NA no no no no no no Alcoholism Amino sugar and nucleotide sugar metabolism 0 0 -0.56036036 kegg kegg NA NA no no no no no no Alcoholism Aminoacyl-tRNA biosynthesis -0.622608696 -0.653162055 -0.45019305 kegg kegg NA NA no no no no no no Alcoholism Amphetamine addiction 0 0 0.53976834 kegg kegg NA NA no no no no no no Alcoholism Anaerostipes 0 -0.415002709 0 butyrate-producing kegg Genus NA 0.568 no no no no no no Alcoholism Antifolate resistance -0.582608696 0 0 kegg kegg NA NA no no no no no no Alcoholism Antigen processing and presentation 0.410434783 0 0 kegg kegg NA NA no no no no no no Alcoholism Apoptosis - multiple species 0 -0.419960474 0 kegg kegg NA NA no no no no no no Alcoholism Arachidonic acid metabolism 0 0.432806324 0 kegg kegg NA NA no no no no no no Alcoholism Ascorbate and aldarate metabolism -0.529565217 0 -0.694465894 kegg kegg NA NA no no no no no no Alcoholism Autophagy - other 0 -0.450592885 0 kegg kegg NA NA no no no no no no Alcoholism Axon guidance 0.665217391 0 0 kegg kegg NA NA no no no no up up Alcoholism Basal transcription factors 0 -0.442687747 -0.41029601 kegg kegg NA NA no no no no no no Alcoholism beta-Alanine metabolism -0.563478261 0 0 kegg kegg NA NA no no no no no no Alcoholism Bile secretion 0 0.416007905 0.638610039 kegg kegg NA NA no no no no no no Alcoholism Butanoate metabolism -0.450434783 0 0 kegg kegg NA NA no no no no no no Alcoholism Calcium signaling pathway 0.485217391 0 0 kegg kegg NA NA no no no no up up Alcoholism cAMP signaling pathway 0.433913043 0 0.509395109 yes kegg kegg NA NA no no no no up up Alcoholism Carbohydrate digestion and absorption 0 0 -0.552895753 kegg kegg NA NA no no no no no no Alcoholism Cell cycle 0 -0.492094862 0 kegg kegg NA NA no no no no no no Alcoholism cGMP-PKG signaling pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Alcoholism Chemokine signaling pathway 0 0.499011858 0.407722008 kegg kegg NA NA no no no no no no Alcoholism Circadian entrainment 0 0 0.679279279 kegg kegg NA NA no no no no up up Alcoholism Circadian rhythm 0 -0.443675889 0 kegg kegg NA NA no no no no no no Alcoholism Citrate cycle (TCA cycle) -0.486956522 0 -0.518918919 kegg kegg NA NA no no no no no no Alcoholism Cocaine addiction 0 0 0.685971686 kegg kegg NA NA no no no no no no Alcoholism Collecting duct acid secretion 0 0.438735178 0 kegg kegg NA NA no no no no no no Alcoholism Complement and coagulation cascades 0 0.527667984 0 kegg kegg NA NA no no no no no no Alcoholism Cortisol synthesis and secretion 0 0 0.575032175 kegg kegg NA NA no no no no no up Alcoholism DNA replication 0 0 -0.422908623 kegg kegg NA NA no no no no no no Alcoholism Dopaminergic synapse 0.492173913 0 0.505276705 kegg kegg NA NA no no no no up no Alcoholism Endocrine and other factor-regulated calcium reabsorption 0 0 0.50990991 kegg kegg NA NA no no no no no no Alcoholism Ether lipid metabolism 0 0 -0.501415701 kegg kegg NA NA no no no no no no Alcoholism Fanconi anemia pathway 0 -0.545454545 -0.496525097 kegg kegg NA NA no no no no no no Alcoholism Fatty acid degradation 0 0 -0.482882883 kegg kegg NA NA no no no no no no Alcoholism Folate biosynthesis 0 -0.529644269 -0.435778636 kegg kegg NA NA no no no no no no Alcoholism Fructose and mannose metabolism -0.460869565 0 -0.491891892 kegg kegg NA NA no no no no no no Alcoholism GABAergic synapse 0 0.516798419 0 kegg kegg NA NA no no no no up up Alcoholism Galactose metabolism -0.556521739 0 -0.637323037 kegg kegg NA NA no no no no no no Alcoholism Gap junction 0 0.483201581 0.628828829 kegg kegg NA NA no no no no no no Alcoholism Glutamatergic synapse 0.419130435 0.556324111 0.662805663 kegg kegg NA NA no no no no up up Alcoholism Glycerolipid metabolism -0.422608696 0 -0.594594595 kegg kegg NA NA no no no no no up Alcoholism Glycerophospholipid metabolism 0 0 -0.58970399 kegg kegg NA NA no no no no no up Alcoholism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.435770751 -0.55006435 kegg kegg NA NA no no no no no no Alcoholism Glycosaminoglycan degradation 0 0 -0.531274131 kegg kegg NA NA no no no no no up Alcoholism Glycosphingolipid biosynthesis - ganglio series 0 -0.466403162 -0.531531532 kegg kegg NA NA no no no no no no Alcoholism GnRH secretion 0 0 -0.483655084 kegg kegg NA NA no no no no up up Alcoholism GnRH signaling pathway 0.44173913 0 0.648906049 kegg kegg NA NA no no no no no no Alcoholism Hedgehog signaling pathway 0 -0.618577075 -0.474646075 kegg kegg NA NA no no no no no no Alcoholism Histidine metabolism -0.632173913 0 -0.610553411 kegg kegg NA NA no no no no no no Alcoholism Homologous recombination 0 -0.523715415 -0.406177606 kegg kegg NA NA no no no no no no Alcoholism Inositol phosphate metabolism -0.659130435 -0.469367589 -0.703989704 kegg kegg NA NA no no no no no no Alcoholism Insulin secretion 0 0 0.570656371 yes kegg kegg NA NA no no no no up up Alcoholism JAK-STAT signaling pathway 0 0 -0.473873874 kegg kegg NA NA no no no no no no Alcoholism Long-term depression 0 0.43083004 0.681081081 kegg kegg NA NA no no no no no no Alcoholism Long-term potentiation 0.410434783 0 0 kegg kegg NA NA no no no no no up Alcoholism Lysine degradation 0 -0.691699605 -0.451222651 kegg kegg NA NA no no no no no no Alcoholism Mannose type O-glycan biosynthesis 0 -0.708498024 0 kegg kegg NA NA no no no no no no Alcoholism MAPK signaling pathway 0 -0.473320158 -0.418018018 kegg kegg NA NA no no no no no no Alcoholism Maturity onset diabetes of the young 0 0 -0.540540541 kegg kegg NA NA no no no no up no Alcoholism Melanogenesis 0 0 0.482882883 kegg kegg NA NA no no no no no no Alcoholism Methanobrevibacter 0 -0.422326513 0 kegg Genus NA 0.629 no no no no no no Alcoholism Morphine addiction 0.467826087 0 0.751866152 kegg kegg NA NA no no no no up up Alcoholism mRNA surveillance pathway 0 -0.448616601 0 kegg kegg NA NA no no no no no no Alcoholism Mucin type O-glycan biosynthesis 0 -0.470355731 0 kegg kegg NA NA no no no no no no Alcoholism N-Glycan biosynthesis 0 -0.477272727 -0.420849421 kegg kegg NA NA no no no no no no Alcoholism Neutrophil extracellular trap formation 0 0.559288538 0 kegg kegg NA NA no no no no no no Alcoholism Nicotine addiction 0 -0.455533597 0 kegg kegg NA NA no no no no up up Alcoholism Nitrogen metabolism 0 0.442687747 0 kegg kegg NA NA no no no no no no Alcoholism Notch signaling pathway 0 0 -0.508365508 kegg kegg NA NA no no no no no no Alcoholism Olfactory transduction 0 0.459486166 0 kegg kegg NA NA no no no no no no Alcoholism One carbon pool by folate -0.484347826 0 -0.5997426 kegg kegg NA NA no no no no no no Alcoholism Other glycan degradation 0 -0.42687747 -0.554954955 kegg kegg NA NA no no no no no no Alcoholism Other types of O-glycan biosynthesis 0 -0.522727273 -0.527413127 kegg kegg NA NA no no no no no no Alcoholism Ovarian steroidogenesis 0 0 0.624967825 kegg kegg NA NA no no no no up up Alcoholism Oxytocin signaling pathway 0 0.53458498 0 kegg kegg NA NA no no no no no no Alcoholism Pancreatic secretion 0.452173913 0 0.645817246 kegg kegg NA NA no no no no no no Alcoholism "Parathyroid hormone synthesis, secretion and action" 0 0 0.471814672 kegg kegg NA NA no no no no no no Alcoholism Pentose and glucuronate interconversions 0 -0.434782609 0 kegg kegg NA NA no no no no no no Alcoholism Pentose phosphate pathway 0 0.43083004 0 kegg kegg NA NA no no no no no no Alcoholism Phenylalanine metabolism -0.479130435 0 -0.454568855 kegg kegg NA NA no no no no no no Alcoholism Phosphatidylinositol signaling system 0 0 -0.441441441 kegg kegg NA NA no no no no no no Alcoholism Platinum drug resistance 0 -0.508893281 -0.438867439 kegg kegg NA NA no no no no no no Alcoholism Progesterone-mediated oocyte maturation 0 -0.518774704 -0.473616474 kegg kegg NA NA no no no no no no Alcoholism Protein digestion and absorption -0.486956522 0 0 yes kegg kegg NA NA no no no no up up Alcoholism Protein processing in endoplasmic reticulum 0 -0.454545455 0 kegg kegg NA NA no no no no no no Alcoholism Pyruvate metabolism -0.43826087 0 0 kegg kegg NA NA no no no no no no Alcoholism Rap1 signaling pathway 0 0.421936759 0 kegg kegg NA NA no no no no no no Alcoholism Ras signaling pathway 0.484347826 0 0 yes kegg kegg NA NA no no no no up up Alcoholism Regulation of lipolysis in adipocytes 0 0 0.593307593 kegg kegg NA NA no no no no no no Alcoholism Relaxin signaling pathway 0 0 0.552380952 kegg kegg NA NA no no no no no no Alcoholism Renin secretion 0 0 0.572200772 kegg kegg NA NA no no no no no no Alcoholism Retinol metabolism 0 0 -0.491119691 kegg kegg NA NA no no no no no no Alcoholism Retrograde endocannabinoid signaling 0.407826087 0 0 kegg kegg NA NA no no no no no up Alcoholism Ribosome biogenesis in eukaryotes 0 -0.535573123 -0.47001287 kegg kegg NA NA no no no no no no Alcoholism RNA degradation 0 -0.48715415 0 kegg kegg NA NA no no no no no no Alcoholism RNA polymerase 0 -0.516798419 -0.450965251 kegg kegg NA NA no no no no no no Alcoholism Ruminococcus 0 -0.470355731 0 acetate-producing kegg Genus NA 0.335 no no no no no no Alcoholism Salivary secretion 0.437391304 0.557312253 0.661518662 kegg kegg NA NA no no no no no no Alcoholism Selenocompound metabolism 0 -0.472332016 -0.67001287 kegg kegg NA NA no no no no no no Alcoholism Serotonergic synapse 0 0.62055336 0.671814672 kegg kegg NA NA no no no no no no Alcoholism Signaling pathways regulating pluripotency of stem cells 0 -0.498023715 0 kegg kegg NA NA no no no no no no Alcoholism Sphingolipid metabolism 0 0 -0.41003861 kegg kegg NA NA no no no no no no Alcoholism Spinocerebellar ataxia 0 -0.603754941 -0.458429858 kegg kegg NA NA no no no no no no Alcoholism Spliceosome 0 -0.588932806 0 kegg kegg NA NA no no no no no no Alcoholism Starch and sucrose metabolism 0 0 -0.43011583 kegg kegg NA NA no no no no no no Alcoholism Steroid biosynthesis 0 0 -0.404890605 kegg kegg NA NA no no no no no no Alcoholism Steroid hormone biosynthesis 0 0 -0.638867439 kegg kegg NA NA no no no no no no Alcoholism Synaptic vesicle cycle 0 0.418972332 0 kegg kegg NA NA no no no no up up Alcoholism Synthesis and degradation of ketone bodies 0 0 -0.427799228 kegg kegg NA NA no no no no no no Alcoholism T cell receptor signaling pathway 0 -0.48715415 0 kegg kegg NA NA no no no no no no Alcoholism Taste transduction 0 0 -0.64993565 kegg kegg NA NA no no no no no up Alcoholism Taurine and hypotaurine metabolism 0 0 -0.434749035 kegg kegg NA NA no no no no no no Alcoholism Terpenoid backbone biosynthesis 0 0 -0.501158301 kegg kegg NA NA no no no no no no Alcoholism Th1 and Th2 cell differentiation 0 -0.483201581 0 kegg kegg NA NA no no no no no no Alcoholism Th17 cell differentiation 0 -0.539525692 0 kegg kegg NA NA no no no no no no Alcoholism Thyroid hormone synthesis 0 0 0.523294723 kegg kegg NA NA no no no no no no Alcoholism Tryptophan metabolism -0.528695652 0 -0.454311454 kegg kegg NA NA no no no no up no Alcoholism Type II diabetes mellitus 0 0 -0.531016731 kegg kegg NA NA no no no no no no Alcoholism Ubiquinone and other terpenoid-quinone biosynthesis -0.43826087 0 -0.484942085 kegg kegg NA NA no no no no no no Alcoholism "Valine, leucine and isoleucine degradation" -0.54173913 0 -0.455855856 kegg kegg NA NA no no no no no no Alcoholism Various types of N-glycan biosynthesis 0 -0.545454545 -0.40978121 kegg kegg NA NA no no no no no no Alcoholism Vascular smooth muscle contraction 0.532173913 0 0.618790219 kegg kegg NA NA no no no no no no Alcoholism Vasopressin-regulated water reabsorption 0 0 0.614414414 kegg kegg NA NA no no no no no no Alcoholism Viral protein interaction with cytokine and cytokine receptor 0.470434783 0.660079051 0.428056628 kegg kegg NA NA no no no no no no Alcoholism Wnt signaling pathway 0 -0.433794466 0 kegg kegg NA NA no no no no no no Aldosterone synthesis and secretion 2-Oxocarboxylic acid metabolism -0.425217391 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion ABC transporters -0.640869565 0 0 kegg kegg NA NA no up up no up up Aldosterone synthesis and secretion Adrenergic signaling in cardiomyocytes 0.831304348 0.854743083 0.912998713 kegg kegg NA NA no up up no no up Aldosterone synthesis and secretion "Alanine, aspartate and glutamate metabolism" -0.494782609 -0.646245059 -0.531274131 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion alpha-Linolenic acid metabolism -0.805217391 -0.586956522 -0.603861004 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Amino sugar and nucleotide sugar metabolism -0.606956522 0 -0.517117117 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Aminoacyl-tRNA biosynthesis -0.459130435 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion AMPK signaling pathway 0 0.608695652 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Antigen processing and presentation -0.415652174 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Apelin signaling pathway 0 0.605731225 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Apoptosis -0.599130435 -0.666007905 -0.421621622 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Arginine and proline metabolism -0.676521739 -0.685770751 -0.42033462 kegg kegg NA NA no up up no up no Aldosterone synthesis and secretion Arginine biosynthesis -0.529565217 -0.637351779 -0.523294723 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Ascorbate and aldarate metabolism 0 0 -0.431917632 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Autophagy - animal 0 -0.471343874 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion B cell receptor signaling pathway 0 -0.593873518 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Basal transcription factors 0 0.442687747 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion beta-Alanine metabolism -0.584347826 0 -0.517631918 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Biosynthesis of amino acids -0.665217391 -0.836956522 -0.648906049 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Biosynthesis of cofactors 0 0.549407115 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Butanoate metabolism -0.442608696 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion C-type lectin receptor signaling pathway 0 -0.60770751 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Calcium signaling pathway 0.845217391 0.78458498 0.871042471 kegg kegg NA NA no up up no up up Aldosterone synthesis and secretion cAMP signaling pathway 0.587826087 0 0.583526384 yes kegg kegg NA NA no up up no up up Aldosterone synthesis and secretion Carbon metabolism -0.583478261 -0.565217391 -0.718661519 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Cardiac muscle contraction 0.59826087 0.756916996 0.42007722 kegg kegg NA NA no up up no no up Aldosterone synthesis and secretion Cell adhesion molecules 0 -0.739130435 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Cell cycle 0 0.590909091 0.437580438 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Cellular senescence 0 -0.606719368 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion cGMP-PKG signaling pathway 0 -0.747035573 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Chemokine signaling pathway 0 -0.500988142 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Circadian entrainment 0.622608696 0.580039526 0.675160875 kegg kegg NA NA no up up no up up Aldosterone synthesis and secretion Circadian rhythm 0.500869565 0.619565217 0.431917632 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Complement and coagulation cascades -0.512173913 -0.731225296 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Coprococcus 0 0 -0.490250339 butyrate-producing kegg Genus NA 0.612 no up up no no no Aldosterone synthesis and secretion Cytokine-cytokine receptor interaction 0 -0.415019763 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion DNA replication 0 0.456521739 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Dopaminergic synapse 0.762608696 0.759881423 0.911454311 kegg kegg NA NA no up up no up no Aldosterone synthesis and secretion Drug metabolism - other enzymes -0.537391304 0 -0.508365508 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion ECM-receptor interaction 0 0 0.434234234 kegg kegg NA NA no up up no up up Aldosterone synthesis and secretion EGFR tyrosine kinase inhibitor resistance 0 0.561264822 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Endocrine resistance 0.794782609 0.654150198 0.674388674 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Endocytosis 0 -0.741106719 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Estrogen signaling pathway 0 0.424901186 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Ether lipid metabolism 0.491304348 0.551383399 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Fatty acid biosynthesis -0.48173913 -0.673913043 -0.511969112 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Fatty acid degradation -0.68173913 -0.678853755 -0.721750322 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Fatty acid elongation -0.427826087 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Fatty acid metabolism -0.713913043 -0.725296443 -0.62007722 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Fc epsilon RI signaling pathway 0 -0.658102767 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Fc gamma R-mediated phagocytosis -0.615652174 -0.815217391 -0.542857143 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Fructose and mannose metabolism -0.670434783 0 -0.685199485 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion GABAergic synapse 0 -0.429841897 0 kegg kegg NA NA no up up no up up Aldosterone synthesis and secretion Galactose metabolism -0.715652174 -0.606719368 -0.560617761 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Gap junction 0.664347826 0.438735178 0.425740026 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Glucagon signaling pathway 0.830434783 0.933794466 0.842471042 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Glutamatergic synapse 0.613913043 0 0 kegg kegg NA NA no up up no up up Aldosterone synthesis and secretion Glutathione metabolism 0 0.621541502 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Glycerolipid metabolism -0.451304348 0 0 kegg kegg NA NA no up up no no up Aldosterone synthesis and secretion "Glycine, serine and threonine metabolism" 0 0.548418972 0 kegg kegg NA NA no up up no up no Aldosterone synthesis and secretion Glycolysis / Gluconeogenesis -0.502608696 0 -0.472072072 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.427865613 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Glycosaminoglycan biosynthesis - keratan sulfate 0.615652174 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Glycosaminoglycan degradation 0 -0.679841897 0 kegg kegg NA NA no up up no no up Aldosterone synthesis and secretion Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.422924901 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Glyoxylate and dicarboxylate metabolism -0.657391304 -0.669960474 -0.615186615 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion GnRH signaling pathway 0.905217391 0.865612648 0.897812098 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Hedgehog signaling pathway 0.563478261 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Hippo signaling pathway - multiple species -0.413043478 -0.587944664 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Histidine metabolism -0.58 0 -0.697812098 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion IL-17 signaling pathway 0 -0.70256917 -0.505534106 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Inflammatory mediator regulation of TRP channels 0.889565217 0.856719368 0.915057915 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Insulin secretion 0.823478261 0.885375494 0.879021879 yes kegg kegg NA NA no up up no up up Aldosterone synthesis and secretion Insulin signaling pathway 0 0.546442688 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Long-term depression 0.844347826 0.467391304 0.692664093 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Long-term potentiation 0.469565217 0 0 kegg kegg NA NA no up up no no up Aldosterone synthesis and secretion Longevity regulating pathway 0.467826087 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Longevity regulating pathway - multiple species 0 -0.504940711 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Lysosome 0 -0.719367589 -0.619305019 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Melanogenesis 0.847826087 0.906126482 0.933075933 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Mitophagy - animal 0.616521739 0.732213439 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion mRNA surveillance pathway 0.553913043 0.736166008 0.513513514 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion mTOR signaling pathway 0 0.532608696 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion N-Glycan biosynthesis 0 0.563241107 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Natural killer cell mediated cytotoxicity 0 -0.652173913 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Necroptosis 0.542608696 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Neuroactive ligand-receptor interaction -0.486956522 -0.793478261 -0.552123552 kegg kegg NA NA no up up up up up Aldosterone synthesis and secretion Neutrophil extracellular trap formation -0.582608696 -0.736166008 -0.482625483 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion NF-kappa B signaling pathway -0.491304348 -0.507905138 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Nicotinate and nicotinamide metabolism -0.605217391 -0.651185771 -0.560875161 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Nitrogen metabolism -0.407826087 -0.504940711 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion NOD-like receptor signaling pathway -0.692173913 -0.718379447 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Non-homologous end-joining -0.412173913 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Nucleotide excision repair 0 0.43083004 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Odoribacter -0.410611339 0 0 butyrate-producing kegg Genus NA 0.798 no up up no no no Aldosterone synthesis and secretion Olfactory transduction 0 -0.692687747 -0.618790219 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion One carbon pool by folate 0 0.463438735 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Oocyte meiosis 0 0 0.432689833 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Osteoclast differentiation -0.7 -0.790513834 -0.439124839 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Other glycan degradation -0.626956522 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Other types of O-glycan biosynthesis 0 0.43972332 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Ovarian steroidogenesis 0.663478261 0.640316206 0.554697555 kegg kegg NA NA no up up no up up Aldosterone synthesis and secretion Oxidative phosphorylation 0.555652174 0.745059289 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Pantothenate and CoA biosynthesis -0.490434783 -0.734189723 -0.723294723 kegg kegg NA NA no up up no no dn Aldosterone synthesis and secretion Pentose phosphate pathway -0.522608696 -0.795454545 -0.675933076 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Peroxisome -0.680869565 -0.742094862 -0.555469755 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Phagosome 0 -0.742094862 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Phosphatidylinositol signaling system 0.589565217 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Porphyrin and chlorophyll metabolism 0 0.462450593 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion PPAR signaling pathway -0.442608696 -0.735177866 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Prevotella -0.415215659 0 0 kegg Genus NA 0.367 no up up no no no Aldosterone synthesis and secretion Prevotella 0 0 0.47767746 acetate-producing kegg Genus NA 0.287 no up up no no no Aldosterone synthesis and secretion Prolactin signaling pathway 0 -0.554347826 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Proteasome 0 0 -0.458944659 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Protein export 0.442608696 0.496047431 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Protein processing in endoplasmic reticulum 0.463478261 0.595849802 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Purine metabolism 0 0.548418972 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Pyrimidine metabolism -0.593043478 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Pyruvate metabolism 0 0.440711462 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Ras signaling pathway 0 0.469367589 0 yes kegg kegg NA NA no up up no up up Aldosterone synthesis and secretion Regulation of lipolysis in adipocytes 0.769565217 0.670948617 0.702960103 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Renin secretion 0.686086957 0.772727273 0.696267696 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Renin-angiotensin system 0 -0.772727273 -0.551093951 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Retinol metabolism -0.477391304 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Retrograde endocannabinoid signaling 0 0.685770751 0 kegg kegg NA NA no up up no no up Aldosterone synthesis and secretion Ribosome 0.553913043 0.691699605 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Ribosome biogenesis in eukaryotes 0 0.517786561 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion RIG-I-like receptor signaling pathway 0 -0.524703557 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion RNA degradation 0.527826087 0.690711462 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion RNA polymerase 0 0.674901186 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Sarcina 0 -0.422326513 0 kegg Genus NA 0.0703 no up up no no no Aldosterone synthesis and secretion Signaling pathways regulating pluripotency of stem cells 0.445217391 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion SNARE interactions in vesicular transport -0.526956522 -0.455533597 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Sphingolipid metabolism 0 0 -0.464607465 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Sphingolipid signaling pathway 0 -0.517786561 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Starch and sucrose metabolism -0.733913043 -0.681818182 -0.720978121 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Steroid biosynthesis 0.448695652 0 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Synaptic vesicle cycle 0 -0.76284585 -0.696267696 kegg kegg NA NA no up up no up up Aldosterone synthesis and secretion Taste transduction 0 0.456521739 0 kegg kegg NA NA no up up no no up Aldosterone synthesis and secretion TGF-beta signaling pathway 0.486956522 0.491106719 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Th1 and Th2 cell differentiation 0 -0.46541502 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Th17 cell differentiation 0 -0.480237154 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Thermogenesis 0.633913043 0.772727273 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Thyroid hormone signaling pathway 0 0.424901186 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Thyroid hormone synthesis 0.733913043 0.802371542 0.531788932 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion TNF signaling pathway 0 -0.425889328 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Toll-like receptor signaling pathway 0 -0.644268775 0 yes kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Tryptophan metabolism -0.5 0 -0.413899614 kegg kegg NA NA no up up no up no Aldosterone synthesis and secretion Ubiquitin mediated proteolysis 0.663478261 0.789525692 0 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Vascular smooth muscle contraction 0.787826087 0.683794466 0.65971686 kegg kegg NA NA no up up no no no Aldosterone synthesis and secretion Wnt signaling pathway 0.619130435 0.695652174 0 kegg kegg NA NA no up up no no no Aldosterone-regulated sodium reabsorption 2-Oxocarboxylic acid metabolism -0.576521739 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption ABC transporters -0.439130435 0 0 kegg kegg NA NA no no no no up up Aldosterone-regulated sodium reabsorption Adrenergic signaling in cardiomyocytes 0.535652174 0 0 kegg kegg NA NA no no no no no up Aldosterone-regulated sodium reabsorption AGE-RAGE signaling pathway in diabetic complications 0.488695652 0.5256917 0.689317889 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Amino sugar and nucleotide sugar metabolism -0.613913043 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Aminoacyl-tRNA biosynthesis -0.46173913 -0.511857708 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Antifolate resistance -0.50173913 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Apoptosis 0 0.416996047 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Arachidonic acid metabolism -0.665217391 0 -0.545431145 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Arginine and proline metabolism 0 0.448616601 0 kegg kegg NA NA no no no no up no Aldosterone-regulated sodium reabsorption Ascorbate and aldarate metabolism -0.496521739 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Autophagy - animal 0.599130435 0.514822134 0.784555985 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Autophagy - other 0.448695652 0 0.482882883 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Axon guidance 0.626086957 0.633399209 0.567052767 kegg kegg NA NA no no no no up up Aldosterone-regulated sodium reabsorption B cell receptor signaling pathway 0 0.546442688 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption beta-Alanine metabolism -0.657391304 -0.463438735 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Biosynthesis of cofactors -0.673043478 -0.414031621 -0.425997426 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Biosynthesis of unsaturated fatty acids -0.512173913 -0.471343874 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Butanoate metabolism -0.682608696 -0.502964427 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption C-type lectin receptor signaling pathway 0.671304348 0.572134387 0.431917632 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Calcium signaling pathway 0.527826087 0 0 kegg kegg NA NA no no no no up up Aldosterone-regulated sodium reabsorption cAMP signaling pathway 0.644347826 0 0 yes kegg kegg NA NA no no no no up up Aldosterone-regulated sodium reabsorption Carbon metabolism -0.480869565 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Cellular senescence 0 0.458498024 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption cGMP-PKG signaling pathway 0.526086957 0 0.471814672 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Chemokine signaling pathway 0.452173913 0.520750988 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Cholinergic synapse 0.712173913 0 0.477477477 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Circadian entrainment 0 0 -0.416988417 kegg kegg NA NA no no no no up up Aldosterone-regulated sodium reabsorption Circadian rhythm 0.599130435 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Citrate cycle (TCA cycle) -0.511304348 -0.551383399 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption DNA replication 0 -0.503952569 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Drug metabolism - cytochrome P450 0 -0.529644269 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Drug metabolism - other enzymes -0.594782609 -0.416007905 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption ErbB signaling pathway 0.74 0.704545455 0.741827542 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Estrogen signaling pathway 0 -0.619565217 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Fatty acid biosynthesis 0 0 0.415701416 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Fatty acid elongation -0.535652174 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Fc epsilon RI signaling pathway 0.597391304 0.548418972 0.56036036 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Ferroptosis 0 0 -0.422136422 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption FoxO signaling pathway 0.44173913 0 0.445302445 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Fructose and mannose metabolism -0.583478261 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Galactose metabolism -0.58173913 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Glucagon signaling pathway 0 -0.425889328 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Glutathione metabolism -0.496521739 0 -0.603088803 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption "Glycine, serine and threonine metabolism" -0.451304348 0 0 kegg kegg NA NA no no no no up no Aldosterone-regulated sodium reabsorption Glycolysis / Gluconeogenesis -0.530434783 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.52173913 0.45971686 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.440711462 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption GnRH secretion 0.77826087 0.643280632 0.614414414 kegg kegg NA NA no no no no up up Aldosterone-regulated sodium reabsorption "Growth hormone synthesis, secretion and action" 0.607826087 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Hedgehog signaling pathway 0.415652174 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Hippo signaling pathway - multiple species 0 0 0.492406692 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Histidine metabolism -0.536521739 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Inflammatory mediator regulation of TRP channels 0.422608696 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Insulin resistance 0.488695652 0.505928854 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Linoleic acid metabolism -0.423478261 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Long-term potentiation 0.56 0 0 kegg kegg NA NA no no no no no up Aldosterone-regulated sodium reabsorption MAPK signaling pathway 0 0 0.579150579 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Metabolism of xenobiotics by cytochrome P450 0 -0.556324111 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Mismatch repair -0.534782609 -0.527667984 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Mitophagy - animal 0 0 -0.566537967 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Necroptosis 0 0 -0.406177606 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Neurotrophin signaling pathway 0.693043478 0.639328063 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption NF-kappa B signaling pathway 0 0.481225296 0.42007722 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Non-alcoholic fatty liver disease 0 0 -0.428056628 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Non-homologous end-joining -0.519130435 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Notch signaling pathway 0 0.438735178 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Nucleotide excision repair 0 -0.548418972 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption One carbon pool by folate 0 -0.461462451 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Osteoclast differentiation 0 0.454545455 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Pentose and glucuronate interconversions -0.58173913 -0.503952569 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Phenylalanine metabolism -0.614782609 -0.552371542 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Phosphatidylinositol signaling system 0.510434783 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Phospholipase D signaling pathway 0.463478261 0 0.408236808 kegg kegg NA NA no no no no up up Aldosterone-regulated sodium reabsorption Phototransduction 0 -0.416996047 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Porphyrin and chlorophyll metabolism 0 0 -0.458429858 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Primary bile acid biosynthesis -0.580869565 -0.449604743 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Progesterone-mediated oocyte maturation 0.570434783 0 0.532561133 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Prolactin signaling pathway 0.796521739 0.503952569 0.515830116 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Proteasome 0 -0.42687747 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Protein processing in endoplasmic reticulum 0 0 -0.422393822 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Pyrimidine metabolism -0.586086957 -0.427865613 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Pyruvate metabolism -0.41826087 -0.468379447 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Ras signaling pathway 0.444347826 0 0 yes kegg kegg NA NA no no no no up up Aldosterone-regulated sodium reabsorption Relaxin signaling pathway 0.46 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Renin secretion 0 -0.43972332 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Renin-angiotensin system 0 0 0.446846847 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Retinol metabolism 0 -0.563241107 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Ribosome 0 0 -0.553410553 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption RIG-I-like receptor signaling pathway 0.456521739 0.508893281 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption RNA polymerase 0 -0.433794466 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Signaling pathways regulating pluripotency of stem cells 0.732173913 0.506916996 0.549034749 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Sphingolipid signaling pathway 0.880869565 0.758893281 0.646589447 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Steroid biosynthesis 0 -0.561264822 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Steroid hormone biosynthesis -0.582608696 -0.495059289 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Sulfur metabolism -0.592173913 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Synthesis and degradation of ketone bodies -0.422608696 -0.497035573 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption T cell receptor signaling pathway 0.428695652 0 0.473873874 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Taste transduction 0 -0.618577075 0 kegg kegg NA NA no no no no no up Aldosterone-regulated sodium reabsorption Thermogenesis 0 0 -0.465379665 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Thiamine metabolism -0.440869565 0 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Thyroid hormone synthesis 0 0 -0.493436293 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Tight junction -0.515652174 0 -0.428571429 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption TNF signaling pathway 0.606086957 0.579051383 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Toll-like receptor signaling pathway 0.617391304 0.514822134 0 yes kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Tryptophan metabolism -0.642608696 -0.458498024 0 kegg kegg NA NA no no no no up no Aldosterone-regulated sodium reabsorption Type II diabetes mellitus 0.803478261 0.695652174 0.674131274 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Tyrosine metabolism -0.58 -0.567193676 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Ubiquinone and other terpenoid-quinone biosynthesis -0.747826087 -0.583003953 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Ubiquitin mediated proteolysis 0 0 -0.596653797 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption "Valine, leucine and isoleucine degradation" -0.633043478 -0.598814229 0 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption VEGF signaling pathway 0.874782609 0.803359684 0.651737452 kegg kegg NA NA no no no no no no Aldosterone-regulated sodium reabsorption Viral protein interaction with cytokine and cytokine receptor 0.443478261 0 -0.412355212 kegg kegg NA NA no no no no no no Alistipes Parabacteroides 0 0.414475422 0 Genus Genus 0.0114 4.19E-05 no up no no up up Allograft rejection 2-Oxocarboxylic acid metabolism 0.462608696 0 0 kegg kegg NA NA no no no no no no Allograft rejection Adrenergic signaling in cardiomyocytes 0 -0.43972332 0 kegg kegg NA NA no no no no no up Allograft rejection Aldosterone synthesis and secretion 0 -0.612648221 0 kegg kegg NA NA no no no no up up Allograft rejection Alzheimer disease -0.507826087 0 0 kegg kegg NA NA no no no no no no Allograft rejection Amino sugar and nucleotide sugar metabolism 0 0 -0.411840412 kegg kegg NA NA no no no no no no Allograft rejection Amphetamine addiction -0.426086957 -0.684782609 0 kegg kegg NA NA no no no no no no Allograft rejection AMPK signaling pathway 0 -0.665019763 0 kegg kegg NA NA no no no no no no Allograft rejection Amyotrophic lateral sclerosis -0.455652174 0 0 kegg kegg NA NA no no no no no no Allograft rejection Antifolate resistance 0 0 -0.455598456 kegg kegg NA NA no no no no no no Allograft rejection Antigen processing and presentation 0.469565217 0.533596838 0.645817246 kegg kegg NA NA no no no no no no Allograft rejection Apelin signaling pathway -0.459130435 0 0 kegg kegg NA NA no no no no no no Allograft rejection Apoptosis 0 0.710474308 0 kegg kegg NA NA no no no no no no Allograft rejection Apoptosis - multiple species 0 0 -0.555469755 kegg kegg NA NA no no no no no no Allograft rejection Asthma 0.448695652 0 0 kegg kegg NA NA no no no no no no Allograft rejection Autoimmune thyroid disease 1 1 1 kegg kegg NA NA no no no no no no Allograft rejection Autophagy - other -0.580869565 0 0 kegg kegg NA NA no no no no no no Allograft rejection B cell receptor signaling pathway 0 0.472332016 0 kegg kegg NA NA no no no no no no Allograft rejection Bacteroides 0.433043478 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Allograft rejection Basal transcription factors -0.592173913 -0.584980237 -0.535649936 kegg kegg NA NA no no no no no no Allograft rejection Base excision repair 0 -0.530632411 -0.436550837 kegg kegg NA NA no no no no no no Allograft rejection Biosynthesis of amino acids 0.570434783 0.587944664 0 kegg kegg NA NA no no no no no no Allograft rejection Biosynthesis of cofactors 0 -0.843873518 0 kegg kegg NA NA no no no no no no Allograft rejection Butyricicoccus 0 0 0.471212756 butyrate-producing kegg Genus NA 0.852 no no no no no no Allograft rejection C-type lectin receptor signaling pathway 0 0.523715415 0 kegg kegg NA NA no no no no no no Allograft rejection cAMP signaling pathway -0.452173913 0 0 yes kegg kegg NA NA no no no no up up Allograft rejection Carbon metabolism 0.477391304 0.475296443 0 kegg kegg NA NA no no no no no no Allograft rejection Cardiac muscle contraction -0.428695652 0 0 kegg kegg NA NA no no no no no up Allograft rejection Cell adhesion molecules 0.957391304 0.960474308 0.942599743 kegg kegg NA NA no no no no no no Allograft rejection Cell cycle -0.607826087 -0.612648221 0 kegg kegg NA NA no no no no no no Allograft rejection Cellular senescence 0.830434783 0.935770751 0.886486486 kegg kegg NA NA no no no no no no Allograft rejection Central carbon metabolism in cancer 0 0 -0.444530245 kegg kegg NA NA no no no no no no Allograft rejection cGMP-PKG signaling pathway 0 0.528656126 0 kegg kegg NA NA no no no no no no Allograft rejection Chemical carcinogenesis - receptor activation -0.535652174 -0.588932806 0 kegg kegg NA NA no no no no no no Allograft rejection Chemokine signaling pathway 0 0.451581028 0.466666667 kegg kegg NA NA no no no no no no Allograft rejection Cholesterol metabolism 0 0.708498024 0 yes kegg kegg NA NA no no no no no up Allograft rejection Circadian rhythm -0.499130435 -0.504940711 0 kegg kegg NA NA no no no no no no Allograft rejection Cocaine addiction 0 -0.522727273 0 kegg kegg NA NA no no no no no no Allograft rejection Complement and coagulation cascades 0.528695652 0.57312253 0 kegg kegg NA NA no no no no no no Allograft rejection Cortisol synthesis and secretion 0 -0.627470356 0 kegg kegg NA NA no no no no no up Allograft rejection Cushing syndrome 0 -0.698616601 0 kegg kegg NA NA no no no no no up Allograft rejection Cytosolic DNA-sensing pathway 0 0 0.47979408 kegg kegg NA NA no no no no no no Allograft rejection DNA replication 0 -0.418972332 0 kegg kegg NA NA no no no no no no Allograft rejection Dopaminergic synapse -0.44 -0.524703557 0 kegg kegg NA NA no no no no up no Allograft rejection Endocrine and other factor-regulated calcium reabsorption 0 -0.468379447 0 kegg kegg NA NA no no no no no no Allograft rejection Endocrine resistance 0 -0.563241107 0 kegg kegg NA NA no no no no no no Allograft rejection Endocytosis 0.833043478 0.944664032 0.909137709 kegg kegg NA NA no no no no no no Allograft rejection Epithelial cell signaling in Helicobacter pylori infection 0 0.577075099 0.542084942 kegg kegg NA NA no no no no no no Allograft rejection Epstein-Barr virus infection 0.475652174 0.544466403 0.736422136 kegg kegg NA NA no no no no no no Allograft rejection Estrogen signaling pathway -0.426956522 -0.490118577 0 kegg kegg NA NA no no no no no no Allograft rejection Ether lipid metabolism -0.502608696 -0.698616601 0 kegg kegg NA NA no no no no no no Allograft rejection Fanconi anemia pathway 0 -0.563241107 -0.463320463 kegg kegg NA NA no no no no no no Allograft rejection Fc epsilon RI signaling pathway 0 0.576086957 0 kegg kegg NA NA no no no no no no Allograft rejection Fc gamma R-mediated phagocytosis 0 0.546442688 0 kegg kegg NA NA no no no no no no Allograft rejection Folate biosynthesis -0.459130435 0 0 kegg kegg NA NA no no no no no no Allograft rejection FoxO signaling pathway 0 0 -0.534877735 kegg kegg NA NA no no no no no no Allograft rejection Glucagon signaling pathway 0 -0.62944664 0 kegg kegg NA NA no no no no no no Allograft rejection Glutathione metabolism 0 -0.540513834 0 kegg kegg NA NA no no no no no no Allograft rejection Glycerophospholipid metabolism -0.487826087 -0.472332016 0 kegg kegg NA NA no no no no no up Allograft rejection "Glycine, serine and threonine metabolism" 0 -0.780632411 0 kegg kegg NA NA no no no no up no Allograft rejection Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.424347826 0 0 kegg kegg NA NA no no no no no no Allograft rejection Glycosaminoglycan degradation 0 0.624505929 0 kegg kegg NA NA no no no no no up Allograft rejection Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.752964427 0 kegg kegg NA NA no no no no no no Allograft rejection GnRH signaling pathway 0 -0.553359684 0 kegg kegg NA NA no no no no no no Allograft rejection Hedgehog signaling pathway 0 -0.446640316 0 kegg kegg NA NA no no no no no no Allograft rejection Herpes simplex virus 1 infection 0 0.53458498 0.68957529 kegg kegg NA NA no no no no no no Allograft rejection Homologous recombination 0 -0.505928854 -0.532818533 kegg kegg NA NA no no no no no no Allograft rejection Human cytomegalovirus infection 0.42173913 0.535573123 0.682625483 kegg kegg NA NA no no no no no dn Allograft rejection Human immunodeficiency virus 1 infection 0 0.53458498 0.665894466 kegg kegg NA NA no no no no no no Allograft rejection Human papillomavirus infection 0.839130435 0.90513834 0.841698842 kegg kegg NA NA no no no no no no Allograft rejection Human T-cell leukemia virus 1 infection 0.471304348 0.519762846 0.714543115 kegg kegg NA NA no no no no no no Allograft rejection Huntington disease -0.474782609 0 0 kegg kegg NA NA no no no no no no Allograft rejection IL-17 signaling pathway 0 0.563241107 0 kegg kegg NA NA no no no no no no Allograft rejection Inflammatory mediator regulation of TRP channels 0 -0.421936759 0 kegg kegg NA NA no no no no no no Allograft rejection Influenza A 0.605217391 0.770750988 0.544401544 kegg kegg NA NA no no no no no no Allograft rejection Insulin resistance -0.462608696 0 0 kegg kegg NA NA no no no no no no Allograft rejection Insulin secretion 0 -0.570158103 0 yes kegg kegg NA NA no no no no up up Allograft rejection Insulin signaling pathway -0.450434783 0 0 kegg kegg NA NA no no no no no no Allograft rejection Leukocyte transendothelial migration 0.511304348 0.506916996 0.413127413 kegg kegg NA NA no no no no no no Allograft rejection Long-term potentiation -0.473913043 0 0 kegg kegg NA NA no no no no no up Allograft rejection Longevity regulating pathway 0 -0.471343874 0 kegg kegg NA NA no no no no no no Allograft rejection Lysosome 0 0.704545455 0 kegg kegg NA NA no no no no no no Allograft rejection MAPK signaling pathway -0.595652174 0 0 kegg kegg NA NA no no no no no no Allograft rejection Maturity onset diabetes of the young 0 -0.513833992 0 kegg kegg NA NA no no no no up no Allograft rejection Measles -0.502608696 0 0 kegg kegg NA NA no no no no no no Allograft rejection Mismatch repair 0 -0.545454545 0 kegg kegg NA NA no no no no no no Allograft rejection Mitophagy - animal 0 -0.491106719 0 kegg kegg NA NA no no no no no no Allograft rejection Morphine addiction 0 -0.428853755 0 kegg kegg NA NA no no no no up up Allograft rejection mRNA surveillance pathway -0.593043478 0 0 kegg kegg NA NA no no no no no no Allograft rejection Natural killer cell mediated cytotoxicity 0.822608696 0.95256917 0.8998713 kegg kegg NA NA no no no no no no Allograft rejection Neuroactive ligand-receptor interaction 0 0.615612648 0 kegg kegg NA NA no no no up up up Allograft rejection Neurotrophin signaling pathway 0 0.492094862 0 kegg kegg NA NA no no no no no no Allograft rejection Neutrophil extracellular trap formation 0.406086957 0.612648221 0 kegg kegg NA NA no no no no no no Allograft rejection NOD-like receptor signaling pathway 0 0.490118577 0 kegg kegg NA NA no no no no no no Allograft rejection Non-alcoholic fatty liver disease -0.504347826 0 0 kegg kegg NA NA no no no no no no Allograft rejection Nucleotide excision repair 0 -0.589920949 -0.535907336 kegg kegg NA NA no no no no no no Allograft rejection One carbon pool by folate 0 -0.546442688 0 kegg kegg NA NA no no no no no no Allograft rejection Oocyte meiosis -0.542608696 0 0 kegg kegg NA NA no no no no no no Allograft rejection Osteoclast differentiation 0 0.588932806 0 kegg kegg NA NA no no no no no no Allograft rejection Other types of O-glycan biosynthesis -0.529565217 -0.53458498 -0.400514801 kegg kegg NA NA no no no no no no Allograft rejection Ovarian steroidogenesis 0 -0.457509881 0 kegg kegg NA NA no no no no up up Allograft rejection Oxidative phosphorylation -0.460869565 0 0 kegg kegg NA NA no no no no no no Allograft rejection p53 signaling pathway -0.511304348 -0.491106719 -0.543886744 kegg kegg NA NA no no no no no no Allograft rejection "Parathyroid hormone synthesis, secretion and action" -0.406086957 -0.434782609 0 kegg kegg NA NA no no no no no no Allograft rejection Pathogenic Escherichia coli infection 0 0.7756917 0.474646075 kegg kegg NA NA no no no no no no Allograft rejection Pathways in cancer -0.551304348 0 -0.441698842 kegg kegg NA NA no no no no no no Allograft rejection Pentose phosphate pathway 0.453043478 0.663043478 0 kegg kegg NA NA no no no no no no Allograft rejection Pertussis 0 0.649209486 0 kegg kegg NA NA no no no no no dn Allograft rejection Phagosome 0.895652174 0.916007905 0.814929215 kegg kegg NA NA no no no no no no Allograft rejection PI3K-Akt signaling pathway -0.53826087 0 0 yes kegg kegg NA NA no no no no up up Allograft rejection Platinum drug resistance 0 0 -0.578635779 kegg kegg NA NA no no no no no no Allograft rejection Porphyrin and chlorophyll metabolism 0 -0.745059289 0 kegg kegg NA NA no no no no no no Allograft rejection PPAR signaling pathway 0 0.457509881 0 kegg kegg NA NA no no no no no no Allograft rejection Prion disease -0.459130435 0 0 kegg kegg NA NA no no no no no no Allograft rejection Progesterone-mediated oocyte maturation -0.429565217 0 0 kegg kegg NA NA no no no no no no Allograft rejection Prolactin signaling pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Allograft rejection Protein digestion and absorption 0.426086957 0.456521739 0 yes kegg kegg NA NA no no no no up up Allograft rejection Protein export -0.557391304 0 0 kegg kegg NA NA no no no no no no Allograft rejection Protein processing in endoplasmic reticulum 0 -0.471343874 0 kegg kegg NA NA no no no no no no Allograft rejection Proximal tubule bicarbonate reclamation 0 0 -0.402831403 kegg kegg NA NA no no no no no no Allograft rejection Purine metabolism 0 -0.751976285 0 kegg kegg NA NA no no no no no no Allograft rejection Pyrimidine metabolism 0 -0.423913043 0 kegg kegg NA NA no no no no no no Allograft rejection Pyruvate metabolism 0 -0.431818182 0 kegg kegg NA NA no no no no no no Allograft rejection Renin-angiotensin system 0 0.677865613 0 kegg kegg NA NA no no no no no no Allograft rejection Retinol metabolism 0 -0.414031621 0 kegg kegg NA NA no no no no no no Allograft rejection Retrograde endocannabinoid signaling -0.517391304 0 0 kegg kegg NA NA no no no no no up Allograft rejection Rheumatoid arthritis 0.647826087 0.739130435 0.415444015 kegg kegg NA NA no no no no no no Allograft rejection Ribosome biogenesis in eukaryotes -0.432173913 -0.536561265 0 kegg kegg NA NA no no no no no no Allograft rejection RNA degradation -0.503478261 0 0 kegg kegg NA NA no no no no no no Allograft rejection RNA polymerase -0.46173913 -0.570158103 0 kegg kegg NA NA no no no no no no Allograft rejection Ruminococcus 0 0 0.405662806 acetate-producing kegg Genus NA 0.335 no no no no no no Allograft rejection Salmonella infection 0 0.706521739 0 kegg kegg NA NA no no no no no no Allograft rejection Selenocompound metabolism -0.53826087 -0.531620553 -0.468725869 kegg kegg NA NA no no no no no no Allograft rejection Sphingolipid metabolism 0 0.445652174 0 kegg kegg NA NA no no no no no no Allograft rejection Sphingolipid signaling pathway 0 0.713438735 0 kegg kegg NA NA no no no no no no Allograft rejection Spliceosome -0.415652174 0 0 kegg kegg NA NA no no no no no no Allograft rejection Staphylococcus aureus infection 0.569565217 0.731225296 0 kegg kegg NA NA no no no up no no Allograft rejection Steroid biosynthesis -0.605217391 0 0 kegg kegg NA NA no no no no no no Allograft rejection Synaptic vesicle cycle 0 0.462450593 0 kegg kegg NA NA no no no no up up Allograft rejection Synthesis and degradation of ketone bodies 0 -0.589920949 -0.425740026 kegg kegg NA NA no no no no no no Allograft rejection Systemic lupus erythematosus 0.405217391 0.687747036 0 kegg kegg NA NA no no no no no no Allograft rejection Taste transduction -0.659130435 -0.586956522 0 kegg kegg NA NA no no no no no up Allograft rejection Taurine and hypotaurine metabolism -0.414782609 0 0 kegg kegg NA NA no no no no no no Allograft rejection Terpenoid backbone biosynthesis -0.695652174 0 0 kegg kegg NA NA no no no no no no Allograft rejection Th1 and Th2 cell differentiation 0 0.570158103 0 kegg kegg NA NA no no no no no no Allograft rejection Th17 cell differentiation 0 0.540513834 0 kegg kegg NA NA no no no no no no Allograft rejection Thermogenesis -0.436521739 0 0 kegg kegg NA NA no no no no no no Allograft rejection Thiamine metabolism 0 -0.592885375 0 kegg kegg NA NA no no no no no no Allograft rejection Thyroid hormone synthesis 0 -0.496047431 0 kegg kegg NA NA no no no no no no Allograft rejection Toll-like receptor signaling pathway 0 0.48715415 0.462548263 yes kegg kegg NA NA no no no no no no Allograft rejection Toxoplasmosis 0 0.563241107 0 kegg kegg NA NA no no no no no no Allograft rejection Tuberculosis 0.476521739 0.698616601 0 kegg kegg NA NA no no no no no dn Allograft rejection Type I diabetes mellitus 1 0.999011858 0.999485199 kegg kegg NA NA no no no no no no Allograft rejection Tyrosine metabolism 0 -0.449604743 0 kegg kegg NA NA no no no no no no Allograft rejection Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.449604743 -0.424967825 kegg kegg NA NA no no no no no no Allograft rejection Ubiquitin mediated proteolysis 0 -0.555335968 0 kegg kegg NA NA no no no no no no Allograft rejection Vasopressin-regulated water reabsorption 0 -0.425889328 0 kegg kegg NA NA no no no no no no Allograft rejection Viral carcinogenesis 0.803478261 0.916996047 0.856370656 kegg kegg NA NA no no no no no no Allograft rejection Vitamin digestion and absorption -0.532173913 0 0 kegg kegg NA NA no no no no no no Allograft rejection Yersinia infection 0 0.713438735 0.407207207 kegg kegg NA NA no no no no no no ALP+clinic 14:0+blood 0 -0.603571429 0 yes clinic serum_fattyacid 0.157 0.00572 no no no up no dn ALP+clinic 15-HETE+blood 0.708067693 0 0 clinic serum_ARA 0.157 0.819 no no no no no no ALP+clinic 16:0/16:1-PC+blood 0 -0.657142857 0 clinic serum_phospholipids 0.157 0.00283 no no no up up no ALP+clinic 16:0/18:2-PI+blood 0 -0.542857143 0.410769231 clinic serum_phospholipids 0.157 0.269 no no no no no no ALP+clinic 16:0/20:4-PC+blood 0 0.610714286 0 clinic serum_phospholipids 0.157 0.0262 no no no no up no ALP+clinic 16:0/22:6-PC+blood 0 0.592857143 0 clinic serum_phospholipids 0.157 4.53E-05 no no no no up up ALP+clinic 16:1/18:2-PG+blood 0 -0.696428571 0 clinic serum_phospholipids 0.157 1.40E-08 no no no no up up ALP+clinic 18:0/18:0-PC+blood -0.616099071 0 0 clinic serum_phospholipids 0.157 0.426 no no no no no no ALP+clinic 18:0/18:0-PS+blood -0.494324045 0 0 clinic serum_phospholipids 0.157 0.00617 no no no no up no ALP+clinic 18:0/18:1-PC+blood -0.642930857 0 0 clinic serum_phospholipids 0.157 0.393 no no no no no no ALP+clinic 18:0/18:1-PE+blood 0 -0.621428571 -0.406153846 clinic serum_phospholipids 0.157 0.00716 no no no up up no ALP+clinic 18:0/20:4-PC+blood 0 0.817857143 0 clinic serum_phospholipids 0.157 0.454 no no no no no no ALP+clinic 18:0/20:5-PC+blood 0 0.746428571 0 clinic serum_phospholipids 0.157 0.17 no no no no no no ALP+clinic 18:1/18:1-PE+blood 0 -0.678571429 0 clinic serum_phospholipids 0.157 1.03E-05 no no no up up no ALP+clinic 18:1/18:2-PG+blood 0 -0.535714286 0 clinic serum_phospholipids 0.157 5.58E-07 no no no no up up ALP+clinic 18:1/20:4-PC+blood 0 0.710714286 0 clinic serum_phospholipids 0.157 0.582 no no no no no no ALP+clinic 20:0/20:5-PC+blood 0 0.635714286 0 clinic serum_phospholipids 0.157 0.882 no no no no no no ALP+clinic 20:1-LPA+blood 0 -0.517857143 0 clinic serum_phospholipids 0.157 0.0187 no no no dn dn no ALP+clinic 20:1+blood 0.486068111 0 0 yes clinic serum_fattyacid 0.157 2.56E-05 no no no dn dn dn ALP+clinic 20:3/16:0-PC+blood 0 0.596428571 0 clinic serum_phospholipids 0.157 0.00405 no no no no up up ALP+clinic 20:3/18:0-PC+blood 0 0.617857143 0 clinic serum_phospholipids 0.157 0.296 no no no no no no ALP+clinic 20:4-LPC+blood 0 0.539285714 0 clinic serum_phospholipids 0.157 0.949 no no no no no no ALP+clinic 20:4n6+blood 0 0.610714286 0 clinic serum_fattyacid 0.157 0.133 no no no no no no ALP+clinic 20:5/18:0-PC+blood 0 0.532142857 0 clinic serum_phospholipids 0.157 3.97E-06 no no no no up up ALP+clinic 4-hydroxybenzoic acid+urine 0 0.490196078 0 clinic urine_cometabolism 0.157 0.52 no no no no no no ALP+clinic 9-HODE+blood 0.475748194 0 0 clinic serum_ARA 0.157 0.297 no no no no no no ALP+clinic Apelin signaling pathway 0 0.537662338 0 clinic kegg 0.157 NA no no no no no no ALP+clinic Bacteroides 0 0.526821005 0 LPS-producing clinic Genus 0.157 0.000267 no no no dn dn up ALP+clinic Butyricimonas 0 0.480882312 0 butyrate-producing clinic Genus 0.157 0.17 no no no no no no ALP+clinic C-peptide 0 -0.428571429 0 clinic DM-assocaited hormones 0.157 0.228 no no no no no no ALP+clinic Cholinergic synapse 0 0.493506494 0 clinic kegg 0.157 NA no no no no no no ALP+clinic Collinsella -0.512478395 0 0 clinic Genus 0.157 0.128 no no no no no no ALP+clinic Coronavirus disease - COVID-19 0 0.436363636 0 clinic kegg 0.157 NA no no no no no no ALP+clinic d18:1-18:0-SM+blood 0 0.521428571 0 clinic serum_phospholipids 0.157 0.97 no no no no no no ALP+clinic d18:1-20:0-SM+blood 0 0.696428571 0 clinic serum_phospholipids 0.157 0.933 no no no no no no ALP+clinic d18:1-20:1-SM+blood 0.490196078 0.675 0 clinic serum_phospholipids 0.157 0.0992 no no no no no no ALP+clinic d18:1-24:1-SM+blood 0 0.625 0 clinic serum_phospholipids 0.157 0.0123 no no no no dn dn ALP+clinic DCA+blood 0 0.525 0 clinic serum_bileacids 0.157 0.122 no no no no no no ALP+clinic EGFR tyrosine kinase inhibitor resistance 0 0.536363636 0 clinic kegg 0.157 NA no no no no no no ALP+clinic EPA+blood 0 0.557142857 0 clinic serum_ARA 0.157 0.212 no no no no no no ALP+clinic Ethanolamine+blood -0.494324045 0 0 clinic serum_aminoacids 0.157 0.122 no no no up no no ALP+clinic GDCA+stool 0.550404858 0 0 clinic stool_bileacids 0.157 0.656 no no no no no no ALP+clinic GLCA+blood -0.481933139 0 0 clinic serum_bileacids 0.157 0.319 no no no no no no ALP+clinic HIF-1 signaling pathway 0 0.485714286 0 clinic kegg 0.157 NA no no no no no no ALP+clinic Indole-3-Acetic acid+urine 0 0 -0.457692308 clinic urine_cometabolism 0.157 0.657 no no no no no no ALP+clinic Insulin signaling pathway 0 0.501298701 0 clinic kegg 0.157 NA no no no no no no ALP+clinic L-Alanine+blood 0 0 0.490769231 yes clinic serum_aminoacids 0.157 0.00138 no no no up up no ALP+clinic L-Aspartic acid+blood 0 0 0.510769231 yes clinic serum_aminoacids 0.157 0.0226 no no no up up no ALP+clinic L-Glutamic acid+blood 0 0 0.410769231 yes clinic serum_aminoacids 0.157 6.20E-05 no no no up up no ALP+clinic L-Isoleucine+blood -0.601651187 0 0 yes clinic serum_aminoacids 0.157 5.47E-06 no no no up up no ALP+clinic L-Leucine+blood -0.477812178 0 0 yes clinic serum_aminoacids 0.157 3.22E-05 no no no up up no ALP+clinic L-Methionine+blood 0 0 -0.466153846 clinic serum_aminoacids 0.157 0.626 no no no no no no ALP+clinic L-Proline+blood 0 -0.517857143 0 yes clinic serum_aminoacids 0.157 0.00265 no no no up up no ALP+clinic Legionellosis 0 0.533766234 0 clinic kegg 0.157 NA no no no no no no ALP+clinic Leishmaniasis 0 0.457142857 0 clinic kegg 0.157 NA no no no no no no ALP+clinic mTOR signaling pathway 0 0.490909091 0 clinic kegg 0.157 NA no no no no no no ALP+clinic PI3K-Akt signaling pathway 0 0.511688312 0 yes clinic kegg 0.157 NA no no no no up up ALP+clinic Proteoglycans in cancer 0 0.496103896 0 clinic kegg 0.157 NA no no no no no no ALP+clinic Ribosome 0 0.44025974 0 clinic kegg 0.157 NA no no no no no no ALP+clinic RNA transport 0 0.536363636 0 clinic kegg 0.157 NA no no no no no no ALP+clinic TCA+stool 0 -0.751710379 0 clinic stool_bileacids 0.157 0.458 no no no no no no ALP+clinic TXB2+blood 0 0.558816169 0 yes clinic serum_ARA 0.157 0.0644 no no no dn no no ALP+clinic Valine+blood -0.486068111 0 0 yes clinic serum_aminoacids 0.157 1.22E-06 no no no up up no alpha-Linolenic acid metabolism "Alanine, aspartate and glutamate metabolism" 0 0.654150198 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Amino sugar and nucleotide sugar metabolism 0.719130435 0.504940711 0.637837838 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Arginine and proline metabolism 0.454782609 0.568181818 0 kegg kegg NA NA no no no no up no alpha-Linolenic acid metabolism Arginine biosynthesis 0 0.613636364 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Ascorbate and aldarate metabolism 0 0 0.616216216 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism beta-Alanine metabolism 0.799130435 0 0.558815959 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Citrate cycle (TCA cycle) 0.495652174 0 0.511711712 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Ether lipid metabolism -0.49826087 0 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Fatty acid biosynthesis 0 0.684782609 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Fatty acid degradation 0.580869565 0.701581028 0.62033462 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Fatty acid elongation 0.515652174 0 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Fructose and mannose metabolism 0.802608696 0.555335968 0.564736165 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Galactose metabolism 0.780869565 0.802371542 0.571171171 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Glutathione metabolism 0 -0.633399209 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Glycerolipid metabolism 0 0.638339921 0 kegg kegg NA NA no no no no no up alpha-Linolenic acid metabolism Glycerophospholipid metabolism 0 0.455533597 0 kegg kegg NA NA no no no no no up alpha-Linolenic acid metabolism "Glycine, serine and threonine metabolism" 0 0 -0.457915058 kegg kegg NA NA no no no no up no alpha-Linolenic acid metabolism Glycolysis / Gluconeogenesis 0.74 0 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.541501976 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.493913043 0 0.505019305 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.640869565 -0.545454545 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Glycosaminoglycan degradation 0 0 0.590990991 kegg kegg NA NA no no no no no up alpha-Linolenic acid metabolism Histidine metabolism 0.659130435 0.477272727 0.624710425 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Inositol phosphate metabolism 0 0.424901186 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Linoleic acid metabolism 0.508695652 0 0.442728443 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Mannose type O-glycan biosynthesis -0.511304348 0 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism N-Glycan biosynthesis 0 -0.590909091 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Other glycan degradation 0.547826087 0.503952569 0.62033462 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Oxidative phosphorylation -0.589565217 -0.752964427 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Pentose phosphate pathway 0.55826087 0.424901186 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Phenylalanine metabolism 0.562608696 0 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Primary bile acid biosynthesis 0.416521739 0 0.437065637 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Purine metabolism 0 0 -0.435778636 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Pyrimidine metabolism 0.625217391 0 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Selenocompound metabolism 0 0 0.43037323 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Starch and sucrose metabolism 0.688695652 0.804347826 0.538481338 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Steroid hormone biosynthesis 0.486956522 0 0.482110682 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Tryptophan metabolism 0.664347826 0 0.455598456 kegg kegg NA NA no no no no up no alpha-Linolenic acid metabolism Tyrosine metabolism 0.486086957 0 0.418018018 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.475652174 0 0 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism "Valine, leucine and isoleucine degradation" 0.53826087 0 0.473359073 kegg kegg NA NA no no no no no no alpha-Linolenic acid metabolism Various types of N-glycan biosynthesis 0 -0.516798419 0 kegg kegg NA NA no no no no no no ALT+clinic 12-ketoDCA+blood 0 0 -0.438172789 clinic serum_bileacids 0.00654 0.517 up up no no no no ALT+clinic 13-HODE+blood 0 0 -0.413076923 clinic serum_ARA 0.00654 0.32 up up no no no no ALT+clinic 16:0-LPC+blood 0 0.575 0 clinic serum_phospholipids 0.00654 0.00456 up up no up up no ALT+clinic 16:0/16:0-PC+blood 0 0 -0.467692308 clinic serum_phospholipids 0.00654 0.00079 up up no no up up ALT+clinic 16:0/18:3-PC+blood -0.653250774 0 0 clinic serum_phospholipids 0.00654 0.00216 up up no no up up ALT+clinic 16:1/18:2-PG+blood 0 0.675 0 clinic serum_phospholipids 0.00654 1.40E-08 up up no no up up ALT+clinic 16:1+blood 0 0 -0.433076923 yes clinic serum_fattyacid 0.00654 0.0186 up up no no no dn ALT+clinic 18:2/20:4-PC+blood 0 0 0.443076923 clinic serum_phospholipids 0.00654 0.0145 up up no no no up ALT+clinic 18:2n6c+blood 0 0 -0.422307692 clinic serum_fattyacid 0.00654 0.15 up up no no no no ALT+clinic 18:3n3+blood -0.601651187 0 -0.586153846 clinic serum_fattyacid 0.00654 0.291 up up no no no no ALT+clinic 2-hydroxyhippuric acid+urine 0.628482972 0 0 clinic urine_cometabolism 0.00654 0.215 up up no no no no ALT+clinic 20:1-LPA+blood -0.521155831 0 0 clinic serum_phospholipids 0.00654 0.0187 up up no dn dn no ALT+clinic 3-(3-Hydroxyphenyl)propanoic acid+stool -0.611764706 0 0 clinic stool_cometabolism 0.00654 0.33 up up no no no no ALT+clinic 9-HODE+blood -0.576883385 0 0 clinic serum_ARA 0.00654 0.297 up up no no no no ALT+clinic Adipocytokine signaling pathway 0.486166008 0 0 clinic kegg 0.00654 NA up up no no no no ALT+clinic Cytokine-cytokine receptor interaction 0 -0.438961039 0 clinic kegg 0.00654 NA up up no no no no ALT+clinic d18:1-20:0-SM+blood -0.469556244 0 0 clinic serum_phospholipids 0.00654 0.933 up up no no no no ALT+clinic DHA+blood -0.543859649 0 0 clinic serum_ARA 0.00654 0.872 up up no no no no ALT+clinic Ferroptosis 0.428571429 0 0 clinic kegg 0.00654 NA up up no no no no ALT+clinic GCA+blood 0.488132095 0 0 yes clinic serum_bileacids 0.00654 0.16 up up no no no no ALT+clinic HCA+stool 0 0 0.472614342 clinic stool_bileacids 0.00654 0.155 up up no no no no ALT+clinic iso-DCA+blood -0.574819401 0 0 clinic serum_bileacids 0.00654 0.38 up up no no no no ALT+clinic LCA+blood 0 0 -0.42853081 clinic serum_bileacids 0.00654 0.884 up up no no no no ALT+clinic Mineral absorption 0.512140034 0 0 clinic kegg 0.00654 NA up up no no no no ALT+clinic Necroptosis 0.431959345 0.466233766 0 clinic kegg 0.00654 NA up up no no no no ALT+clinic Ras signaling pathway 0 -0.468831169 0 yes clinic kegg 0.00654 NA up up no no up up ALT+clinic Ruminococcus -0.499509633 0 0 clinic Genus 0.00654 0.0679 up up no no no dn ALT+clinic T-a-MCA+blood 0 0 -0.448189785 clinic serum_bileacids 0.00654 0.478 up up no no no no Alzheimer disease 2-Oxocarboxylic acid metabolism -0.580869565 0 0 kegg kegg NA NA no no no no no no Alzheimer disease ABC transporters -0.407826087 -0.423913043 0 kegg kegg NA NA no no no no up up Alzheimer disease Adherens junction 0 0.663043478 0.48983269 kegg kegg NA NA no no no no no no Alzheimer disease Adrenergic signaling in cardiomyocytes 0.749565217 0.825098814 0.483397683 kegg kegg NA NA no no no no no up Alzheimer disease AGE-RAGE signaling pathway in diabetic complications 0 -0.820158103 0 kegg kegg NA NA no no no no no no Alzheimer disease "Alanine, aspartate and glutamate metabolism" -0.493043478 -0.780632411 -0.589446589 kegg kegg NA NA no no no no no no Alzheimer disease Aldosterone synthesis and secretion 0.58 0.768774704 0.404890605 kegg kegg NA NA no no no no up up Alzheimer disease alpha-Linolenic acid metabolism -0.613913043 -0.767786561 0 kegg kegg NA NA no no no no no no Alzheimer disease Amino sugar and nucleotide sugar metabolism -0.606956522 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Aminoacyl-tRNA biosynthesis -0.613043478 0 0 kegg kegg NA NA no no no no no no Alzheimer disease AMPK signaling pathway 0 0.461462451 0 kegg kegg NA NA no no no no no no Alzheimer disease Apelin signaling pathway 0 0.766798419 0 kegg kegg NA NA no no no no no no Alzheimer disease Apoptosis -0.467826087 -0.583992095 0 kegg kegg NA NA no no no no no no Alzheimer disease Apoptosis - multiple species 0 -0.46541502 0 kegg kegg NA NA no no no no no no Alzheimer disease Arginine and proline metabolism 0 -0.782608696 -0.597940798 kegg kegg NA NA no no no no up no Alzheimer disease Arginine biosynthesis -0.515652174 -0.727272727 -0.55984556 kegg kegg NA NA no no no no no no Alzheimer disease Autophagy - animal 0 -0.718379447 0 kegg kegg NA NA no no no no no no Alzheimer disease Axon guidance 0.516521739 0 0 kegg kegg NA NA no no no no up up Alzheimer disease B cell receptor signaling pathway 0 -0.618577075 0 kegg kegg NA NA no no no no no no Alzheimer disease beta-Alanine metabolism -0.743478261 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Bile secretion 0.42173913 0.488142292 0 kegg kegg NA NA no no no no no no Alzheimer disease Biosynthesis of amino acids -0.817391304 -0.645256917 -0.495238095 kegg kegg NA NA no no no no no no Alzheimer disease Biosynthesis of unsaturated fatty acids -0.426956522 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Butanoate metabolism -0.613913043 0 0 kegg kegg NA NA no no no no no no Alzheimer disease C-type lectin receptor signaling pathway 0 -0.614624506 0 kegg kegg NA NA no no no no no no Alzheimer disease Calcium signaling pathway 0.713913043 0.734189723 0 kegg kegg NA NA no no no no up up Alzheimer disease cAMP signaling pathway 0.796521739 0 0 yes kegg kegg NA NA no no no no up up Alzheimer disease Carbohydrate digestion and absorption 0 -0.470355731 0 kegg kegg NA NA no no no no no no Alzheimer disease Carbon metabolism -0.773913043 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Cardiac muscle contraction 0.968695652 0.966403162 0.97039897 kegg kegg NA NA no no no no no up Alzheimer disease Cell adhesion molecules -0.585217391 -0.438735178 0 kegg kegg NA NA no no no no no no Alzheimer disease Cell cycle 0 0 0.473101673 kegg kegg NA NA no no no no no no Alzheimer disease Cellular senescence 0 -0.435770751 0 kegg kegg NA NA no no no no no no Alzheimer disease cGMP-PKG signaling pathway 0 -0.645256917 0 kegg kegg NA NA no no no no no no Alzheimer disease Chemokine signaling pathway 0 -0.457509881 0 kegg kegg NA NA no no no no no no Alzheimer disease Circadian entrainment 0 0.571146245 0 kegg kegg NA NA no no no no up up Alzheimer disease Circadian rhythm 0.70173913 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Citrate cycle (TCA cycle) 0 0.424901186 0 kegg kegg NA NA no no no no no no Alzheimer disease Complement and coagulation cascades -0.570434783 -0.645256917 0 kegg kegg NA NA no no no no no no Alzheimer disease Cushing syndrome 0.446086957 0.467391304 0 kegg kegg NA NA no no no no no up Alzheimer disease Cysteine and methionine metabolism 0 0.479249012 0 kegg kegg NA NA no no no no no no Alzheimer disease Cytokine-cytokine receptor interaction 0 -0.457509881 0 kegg kegg NA NA no no no no no no Alzheimer disease DNA replication 0 0.442687747 0 kegg kegg NA NA no no no no no no Alzheimer disease Dopaminergic synapse 0.667826087 0.717391304 0 kegg kegg NA NA no no no no up no Alzheimer disease Drug metabolism - cytochrome P450 0 0.506916996 0 kegg kegg NA NA no no no no no no Alzheimer disease Drug metabolism - other enzymes -0.592173913 0.585968379 0 kegg kegg NA NA no no no no no no Alzheimer disease EGFR tyrosine kinase inhibitor resistance 0 0.690711462 0 kegg kegg NA NA no no no no no no Alzheimer disease Endocrine and other factor-regulated calcium reabsorption 0.486956522 0.792490119 0 kegg kegg NA NA no no no no no no Alzheimer disease Endocrine resistance 0.407826087 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Endocytosis -0.479130435 -0.473320158 0 kegg kegg NA NA no no no no no no Alzheimer disease ErbB signaling pathway 0 -0.434782609 0 kegg kegg NA NA no no no no no no Alzheimer disease Ether lipid metabolism 0.695652174 0.471343874 0.448648649 kegg kegg NA NA no no no no no no Alzheimer disease Fat digestion and absorption -0.500869565 -0.62944664 0 yes kegg kegg NA NA no no no no up up Alzheimer disease Fatty acid biosynthesis 0 -0.822134387 -0.597683398 kegg kegg NA NA no no no no no no Alzheimer disease Fatty acid degradation -0.62 -0.85770751 0 kegg kegg NA NA no no no no no no Alzheimer disease Fatty acid elongation -0.553043478 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Fatty acid metabolism -0.751304348 -0.830039526 0 kegg kegg NA NA no no no no no no Alzheimer disease Fc epsilon RI signaling pathway 0 -0.714426877 0 kegg kegg NA NA no no no no no no Alzheimer disease Fc gamma R-mediated phagocytosis -0.44 -0.653162055 -0.496010296 kegg kegg NA NA no no no no no no Alzheimer disease Focal adhesion 0 0.529644269 0.436808237 kegg kegg NA NA no no no no up up Alzheimer disease Folate biosynthesis 0 0.447628458 0 kegg kegg NA NA no no no no no no Alzheimer disease FoxO signaling pathway 0 -0.781620553 0 kegg kegg NA NA no no no no no no Alzheimer disease Fructose and mannose metabolism -0.774782609 -0.566205534 -0.534620335 kegg kegg NA NA no no no no no no Alzheimer disease GABAergic synapse 0 -0.632411067 0 kegg kegg NA NA no no no no up up Alzheimer disease Galactose metabolism -0.78173913 -0.790513834 0 kegg kegg NA NA no no no no no no Alzheimer disease Gastric acid secretion 0 0.720355731 0.43963964 kegg kegg NA NA no no no no no no Alzheimer disease Glucagon signaling pathway 0.434782609 0.760869565 0 kegg kegg NA NA no no no no no no Alzheimer disease Glutathione metabolism 0 0.71541502 0 kegg kegg NA NA no no no no no no Alzheimer disease Glycerolipid metabolism 0 -0.640316206 0 kegg kegg NA NA no no no no no up Alzheimer disease Glycolysis / Gluconeogenesis -0.648695652 0.458498024 0 kegg kegg NA NA no no no no no no Alzheimer disease Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.751976285 0 kegg kegg NA NA no no no no no no Alzheimer disease Glycosaminoglycan biosynthesis - keratan sulfate 0.499130435 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Glycosaminoglycan degradation 0 -0.436758893 0 kegg kegg NA NA no no no no no up Alzheimer disease Glyoxylate and dicarboxylate metabolism -0.656521739 -0.730237154 -0.619305019 kegg kegg NA NA no no no no no no Alzheimer disease GnRH secretion 0 -0.415019763 0 kegg kegg NA NA no no no no up up Alzheimer disease GnRH signaling pathway 0 0.489130435 0 kegg kegg NA NA no no no no no no Alzheimer disease Hedgehog signaling pathway 0.526956522 0 0 kegg kegg NA NA no no no no no no Alzheimer disease HIF-1 signaling pathway 0 0.661067194 0 kegg kegg NA NA no no no no no no Alzheimer disease Hippo signaling pathway 0 0.644268775 0.548262548 kegg kegg NA NA no no no no no no Alzheimer disease Hippo signaling pathway - multiple species 0 -0.743083004 0 kegg kegg NA NA no no no no no no Alzheimer disease IL-17 signaling pathway 0 -0.553359684 -0.52020592 kegg kegg NA NA no no no no no no Alzheimer disease Inflammatory mediator regulation of TRP channels 0.545217391 0.795454545 0 kegg kegg NA NA no no no no no no Alzheimer disease Inositol phosphate metabolism 0 -0.485177866 0 kegg kegg NA NA no no no no no no Alzheimer disease Insulin resistance 0 -0.552371542 0 kegg kegg NA NA no no no no no no Alzheimer disease Insulin secretion 0 0.536561265 0 yes kegg kegg NA NA no no no no up up Alzheimer disease Insulin signaling pathway 0 0.707509881 0 kegg kegg NA NA no no no no no no Alzheimer disease JAK-STAT signaling pathway 0 -0.764822134 0 kegg kegg NA NA no no no no no no Alzheimer disease Long-term depression 0.533043478 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Long-term potentiation 0.439130435 0 0.464864865 kegg kegg NA NA no no no no no up Alzheimer disease Lysosome 0 0 -0.402574003 kegg kegg NA NA no no no no no no Alzheimer disease Mannose type O-glycan biosynthesis 0.444347826 0 0 kegg kegg NA NA no no no no no no Alzheimer disease MAPK signaling pathway 0 -0.686758893 0 kegg kegg NA NA no no no no no no Alzheimer disease Melanogenesis 0.5 0.835968379 0 kegg kegg NA NA no no no no no no Alzheimer disease Metabolism of xenobiotics by cytochrome P450 0 0.458498024 0 kegg kegg NA NA no no no no no no Alzheimer disease Mineral absorption 0.407826087 0.610671937 0 kegg kegg NA NA no no no no no no Alzheimer disease Mitophagy - animal 0.52 0.821146245 0 kegg kegg NA NA no no no no no no Alzheimer disease mRNA surveillance pathway 0.74173913 0.656126482 0.476447876 kegg kegg NA NA no no no no no no Alzheimer disease mTOR signaling pathway 0 0.68972332 0 kegg kegg NA NA no no no no no no Alzheimer disease Mucin type O-glycan biosynthesis 0 -0.415019763 0 kegg kegg NA NA no no no no no no Alzheimer disease N-Glycan biosynthesis 0 0.56027668 0 kegg kegg NA NA no no no no no no Alzheimer disease Natural killer cell mediated cytotoxicity -0.488695652 -0.424901186 0 kegg kegg NA NA no no no no no no Alzheimer disease Neuroactive ligand-receptor interaction 0 -0.511857708 0 kegg kegg NA NA no no no up up up Alzheimer disease Neurotrophin signaling pathway 0.554782609 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Neutrophil extracellular trap formation -0.486086957 -0.532608696 0 kegg kegg NA NA no no no no no no Alzheimer disease NF-kappa B signaling pathway 0 -0.730237154 -0.418790219 kegg kegg NA NA no no no no no no Alzheimer disease Nicotinate and nicotinamide metabolism 0 -0.761857708 -0.544658945 kegg kegg NA NA no no no no no no Alzheimer disease Nitrogen metabolism -0.449565217 -0.618577075 -0.493436293 kegg kegg NA NA no no no no no no Alzheimer disease NOD-like receptor signaling pathway 0 -0.759881423 -0.45019305 kegg kegg NA NA no no no no no no Alzheimer disease Non-alcoholic fatty liver disease 0.990434783 0.961462451 0.852509653 kegg kegg NA NA no no no no no no Alzheimer disease Non-homologous end-joining -0.636521739 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Olfactory transduction 0 -0.60770751 0 kegg kegg NA NA no no no no no no Alzheimer disease Oocyte meiosis 0.482608696 0.462450593 0.501673102 kegg kegg NA NA no no no no no no Alzheimer disease Oscillospira 0 -0.514822134 -0.432175032 LPS-producing kegg Genus NA 0.62 no no no no no no Alzheimer disease Osteoclast differentiation 0 -0.734189723 -0.468468468 kegg kegg NA NA no no no no no no Alzheimer disease Other glycan degradation 0 -0.514822134 0 kegg kegg NA NA no no no no no no Alzheimer disease Oxidative phosphorylation 0.984347826 0.991106719 0.959330759 kegg kegg NA NA no no no no no no Alzheimer disease Pancreatic secretion 0.634782609 0.72826087 0 kegg kegg NA NA no no no no no no Alzheimer disease Pantothenate and CoA biosynthesis 0 -0.805335968 -0.521750322 kegg kegg NA NA no no no no no dn Alzheimer disease "Parathyroid hormone synthesis, secretion and action" 0.671304348 0.805335968 0 kegg kegg NA NA no no no no no no Alzheimer disease Pentose and glucuronate interconversions 0 0.542490119 0.430888031 kegg kegg NA NA no no no no no no Alzheimer disease Pentose phosphate pathway -0.537391304 -0.570158103 -0.554182754 kegg kegg NA NA no no no no no no Alzheimer disease Peroxisome -0.547826087 -0.747035573 -0.515315315 kegg kegg NA NA no no no no no no Alzheimer disease Phagosome -0.615652174 -0.450592885 0 kegg kegg NA NA no no no no no no Alzheimer disease Phosphatidylinositol signaling system 0.580869565 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Phospholipase D signaling pathway 0 -0.552371542 0 kegg kegg NA NA no no no no up up Alzheimer disease Phototransduction 0 0.532608696 0.501158301 kegg kegg NA NA no no no no no no Alzheimer disease Platelet activation 0 0.537549407 0 kegg kegg NA NA no no no no no no Alzheimer disease PPAR signaling pathway 0 -0.597826087 0 kegg kegg NA NA no no no no no no Alzheimer disease Prolactin signaling pathway 0 -0.650197628 -0.407207207 kegg kegg NA NA no no no no no no Alzheimer disease Propanoate metabolism 0 0.451581028 0 kegg kegg NA NA no no no no no no Alzheimer disease Proteasome 0 0.5 0 kegg kegg NA NA no no no no no no Alzheimer disease Protein digestion and absorption -0.64173913 -0.837944664 -0.404118404 yes kegg kegg NA NA no no no no up up Alzheimer disease Protein export 0.56 0.787549407 0.543886744 kegg kegg NA NA no no no no no no Alzheimer disease Protein processing in endoplasmic reticulum 0 0.643280632 0 kegg kegg NA NA no no no no no no Alzheimer disease Proximal tubule bicarbonate reclamation 0 0.48715415 0 kegg kegg NA NA no no no no no no Alzheimer disease Purine metabolism 0 0.444664032 0 kegg kegg NA NA no no no no no no Alzheimer disease Pyrimidine metabolism -0.730434783 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Pyruvate metabolism 0 0.58201581 0 kegg kegg NA NA no no no no no no Alzheimer disease Rap1 signaling pathway 0 0.42687747 0 kegg kegg NA NA no no no no no no Alzheimer disease Ras signaling pathway 0 0.524703557 0.514285714 yes kegg kegg NA NA no no no no up up Alzheimer disease Relaxin signaling pathway 0.534782609 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Renin secretion 0 0.804347826 0 kegg kegg NA NA no no no no no no Alzheimer disease Renin-angiotensin system 0 -0.602766798 0 kegg kegg NA NA no no no no no no Alzheimer disease Retinol metabolism -0.46173913 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Retrograde endocannabinoid signaling 0.831304348 0.924901186 0.828571429 kegg kegg NA NA no no no no no up Alzheimer disease Ribosome 0.704347826 0.886363636 0 kegg kegg NA NA no no no no no no Alzheimer disease RIG-I-like receptor signaling pathway 0 -0.682806324 0 kegg kegg NA NA no no no no no no Alzheimer disease RNA degradation 0.689565217 0.678853755 0.436293436 kegg kegg NA NA no no no no no no Alzheimer disease RNA polymerase 0 0.549407115 0 kegg kegg NA NA no no no no no no Alzheimer disease RNA transport 0 0.583992095 0 kegg kegg NA NA no no no no no no Alzheimer disease Ruminococcus 0 0.419020601 0 kegg Genus NA 0.0679 no no no no no dn Alzheimer disease Signaling pathways regulating pluripotency of stem cells 0.626086957 0 0 kegg kegg NA NA no no no no no no Alzheimer disease SNARE interactions in vesicular transport 0 -0.68083004 0 kegg kegg NA NA no no no no no no Alzheimer disease Sphingolipid signaling pathway 0.482608696 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Starch and sucrose metabolism -0.475652174 -0.827075099 0 kegg kegg NA NA no no no no no no Alzheimer disease Sulfur metabolism -0.449565217 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Synaptic vesicle cycle 0 -0.574110672 0 kegg kegg NA NA no no no no up up Alzheimer disease T cell receptor signaling pathway 0 -0.507905138 0 kegg kegg NA NA no no no no no no Alzheimer disease Taurine and hypotaurine metabolism 0 -0.415019763 0 kegg kegg NA NA no no no no no no Alzheimer disease TGF-beta signaling pathway 0.703478261 0.687747036 0.536422136 kegg kegg NA NA no no no no no no Alzheimer disease Th17 cell differentiation 0 -0.420948617 0 kegg kegg NA NA no no no no no no Alzheimer disease Thermogenesis 0.947826087 0.984189723 0.892921493 kegg kegg NA NA no no no no no no Alzheimer disease Thiamine metabolism 0 0.456521739 0 kegg kegg NA NA no no no no no no Alzheimer disease Thyroid hormone signaling pathway 0 0.636363636 0.525611326 kegg kegg NA NA no no no no no no Alzheimer disease Thyroid hormone synthesis 0 0.621541502 0 kegg kegg NA NA no no no no no no Alzheimer disease Tight junction 0 0.53458498 0 kegg kegg NA NA no no no no no no Alzheimer disease TNF signaling pathway 0 -0.550395257 0 kegg kegg NA NA no no no no no no Alzheimer disease Toll-like receptor signaling pathway 0 -0.646245059 0 yes kegg kegg NA NA no no no no no no Alzheimer disease Tryptophan metabolism -0.559130435 0 0 kegg kegg NA NA no no no no up no Alzheimer disease Type I diabetes mellitus -0.507826087 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Type II diabetes mellitus 0 -0.612648221 0 kegg kegg NA NA no no no no no no Alzheimer disease Ubiquitin mediated proteolysis 0.519130435 0.833992095 0 kegg kegg NA NA no no no no no no Alzheimer disease "Valine, leucine and isoleucine degradation" -0.466956522 0 0 kegg kegg NA NA no no no no no no Alzheimer disease Vascular smooth muscle contraction 0.697391304 0.853754941 0 kegg kegg NA NA no no no no no no Alzheimer disease Vasopressin-regulated water reabsorption 0.536521739 0.761857708 0 kegg kegg NA NA no no no no no no Alzheimer disease VEGF signaling pathway 0 -0.415019763 0 kegg kegg NA NA no no no no no no Alzheimer disease Vitamin digestion and absorption 0.64 -0.432806324 0 kegg kegg NA NA no no no no no no Alzheimer disease Wnt signaling pathway 0.69826087 0.649209486 0.554182754 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Ascorbate and aldarate metabolism 0.490434783 0 0.663835264 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism beta-Alanine metabolism 0.776521739 0 0.595366795 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Citrate cycle (TCA cycle) 0.560869565 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Cysteine and methionine metabolism 0.514782609 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Fatty acid degradation 0.546956522 0 0.553667954 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Fatty acid elongation 0.612173913 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Fructose and mannose metabolism 0.849565217 0.537549407 0.733590734 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Galactose metabolism 0.77826087 0 0.711196911 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Glycolysis / Gluconeogenesis 0.82 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Histidine metabolism 0.68 0.538537549 0.729214929 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Mannose type O-glycan biosynthesis -0.683478261 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Mucin type O-glycan biosynthesis 0.642608696 0.43083004 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Other glycan degradation 0.557391304 0.471343874 0.537709138 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Other types of O-glycan biosynthesis 0 0.482213439 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Oxidative phosphorylation -0.583478261 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Pentose and glucuronate interconversions 0.577391304 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Phenylalanine metabolism 0.48173913 0 0.42007722 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Primary bile acid biosynthesis 0.692173913 0 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Pyrimidine metabolism 0.766956522 0.464426877 0.433976834 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Selenocompound metabolism 0 0.70256917 0.538996139 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Starch and sucrose metabolism 0.677391304 0 0.665637066 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Steroid biosynthesis 0 0.437747036 0.462805663 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Steroid hormone biosynthesis 0.742608696 0.5 0.482368082 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Synthesis and degradation of ketone bodies 0.5 0.514822134 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Tryptophan metabolism 0.726956522 0 0.45045045 kegg kegg NA NA no no no no up no Amino sugar and nucleotide sugar metabolism Tyrosine metabolism 0.647826087 0 0.44967825 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.744347826 0.531620553 0 kegg kegg NA NA no no no no no no Amino sugar and nucleotide sugar metabolism "Valine, leucine and isoleucine degradation" 0.683478261 0 0.54002574 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis alpha-Linolenic acid metabolism 0.573913043 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Amino sugar and nucleotide sugar metabolism 0.633043478 0.539525692 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Arginine and proline metabolism 0 -0.48715415 0 kegg kegg NA NA no no no no up no Aminoacyl-tRNA biosynthesis Arginine biosynthesis 0 -0.476284585 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Ascorbate and aldarate metabolism 0.414782609 0.548418972 0.453539254 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis beta-Alanine metabolism 0.711304348 0.520750988 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Butanoate metabolism 0.768695652 0.742094862 0.484684685 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Citrate cycle (TCA cycle) 0.734782609 0.695652174 0.588674389 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Cysteine and methionine metabolism 0.587826087 0.584980237 0.518146718 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Ether lipid metabolism 0 0.441699605 0.439124839 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Fatty acid degradation 0.465217391 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Fatty acid elongation 0.51826087 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Fructose and mannose metabolism 0.612173913 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Galactose metabolism 0.610434783 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Glycerophospholipid metabolism 0 0 0.522007722 kegg kegg NA NA no no no no no up Aminoacyl-tRNA biosynthesis Glycolysis / Gluconeogenesis 0.677391304 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.59486166 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate -0.529565217 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Glycosaminoglycan degradation -0.568695652 0 0 kegg kegg NA NA no no no no no up Aminoacyl-tRNA biosynthesis Glycosphingolipid biosynthesis - ganglio series 0 0.73715415 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Glycosphingolipid biosynthesis - lacto and neolacto series -0.5 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.468695652 0.462450593 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Glyoxylate and dicarboxylate metabolism 0 -0.494071146 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Histidine metabolism 0.513043478 0.475296443 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Inositol phosphate metabolism 0.448695652 0.461462451 0.481081081 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Lysine degradation 0 0.604743083 0.482882883 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Mucin type O-glycan biosynthesis 0.439130435 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis N-Glycan biosynthesis 0 0.630434783 0.691634492 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Nicotinate and nicotinamide metabolism 0 -0.53458498 -0.447361647 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Nitrogen metabolism 0 -0.604743083 -0.533075933 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis One carbon pool by folate 0.727826087 0.766798419 0.777091377 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Other glycan degradation 0.422608696 0 0.417503218 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Other types of O-glycan biosynthesis 0 0.514822134 0.562676963 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Oxidative phosphorylation -0.594782609 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Pentose and glucuronate interconversions 0.452173913 0.729249012 0.53951094 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Pentose phosphate pathway 0 -0.556324111 -0.401544402 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Phenylalanine metabolism 0.48 0.698616601 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Primary bile acid biosynthesis 0.703478261 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Propanoate metabolism 0.700869565 0.508893281 0.465894466 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Pyrimidine metabolism 0.68 0.565217391 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Pyruvate metabolism 0.749565217 0.554347826 0.494465894 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Retinol metabolism 0.675652174 0.721343874 0.515830116 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Selenocompound metabolism 0 0.67687747 0.734362934 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Sphingolipid metabolism -0.454782609 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Steroid biosynthesis 0 0.56916996 0.512226512 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Steroid hormone biosynthesis 0.43826087 0.621541502 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Synthesis and degradation of ketone bodies 0.715652174 0.723320158 0.601287001 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Taurine and hypotaurine metabolism 0 0 0.425997426 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Terpenoid backbone biosynthesis 0 0.606719368 0.547232947 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Thiamine metabolism 0.490434783 0 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Tryptophan metabolism 0.72173913 0.570158103 0.417245817 kegg kegg NA NA no no no no up no Aminoacyl-tRNA biosynthesis Tyrosine metabolism 0.591304348 0.662055336 0 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis 0.699130435 0.802371542 0.550836551 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis "Valine, leucine and isoleucine degradation" 0.828695652 0.825098814 0.610810811 kegg kegg NA NA no no no no no no Aminoacyl-tRNA biosynthesis Various types of N-glycan biosynthesis 0 0.599802372 0.674646075 kegg kegg NA NA no no no no no no Amoebiasis 2-Oxocarboxylic acid metabolism 0 -0.788537549 0 kegg kegg NA NA no no no no no no Amoebiasis ABC transporters -0.413913043 0 -0.518404118 kegg kegg NA NA no no no no up up Amoebiasis Adipocytokine signaling pathway 0 0.506916996 0 kegg kegg NA NA no no no no no no Amoebiasis African trypanosomiasis 0 0.593873518 0 kegg kegg NA NA no no no no no no Amoebiasis AGE-RAGE signaling pathway in diabetic complications 0 0.811264822 0 kegg kegg NA NA no no no no no no Amoebiasis "Alanine, aspartate and glutamate metabolism" 0 0.748023715 0 kegg kegg NA NA no no no no no no Amoebiasis Alcoholism 0 0.576086957 0.474131274 kegg kegg NA NA no no no no no no Amoebiasis Aldosterone synthesis and secretion 0 -0.440711462 0 kegg kegg NA NA no no no no up up Amoebiasis alpha-Linolenic acid metabolism 0 0.472332016 0 kegg kegg NA NA no no no no no no Amoebiasis Alzheimer disease 0 -0.56027668 0 kegg kegg NA NA no no no no no no Amoebiasis Aminoacyl-tRNA biosynthesis -0.474782609 -0.700592885 -0.455083655 kegg kegg NA NA no no no no no no Amoebiasis Amphetamine addiction 0 -0.566205534 0 kegg kegg NA NA no no no no no no Amoebiasis Amyotrophic lateral sclerosis 0 -0.613636364 0 kegg kegg NA NA no no no no no no Amoebiasis Antifolate resistance 0 0 -0.516087516 kegg kegg NA NA no no no no no no Amoebiasis Apelin signaling pathway -0.48 -0.757905138 -0.614157014 kegg kegg NA NA no no no no no no Amoebiasis Apoptosis 0 0.763833992 0.513513514 kegg kegg NA NA no no no no no no Amoebiasis Arginine and proline metabolism 0 0.76284585 0 kegg kegg NA NA no no no no up no Amoebiasis Arginine biosynthesis 0 0.778656126 0.503474903 kegg kegg NA NA no no no no no no Amoebiasis Ascorbate and aldarate metabolism -0.480869565 0 -0.607464607 kegg kegg NA NA no no no no no no Amoebiasis Autophagy - animal 0 0.647233202 0 kegg kegg NA NA no no no no no no Amoebiasis Autophagy - other 0 0 -0.488803089 kegg kegg NA NA no no no no no no Amoebiasis B cell receptor signaling pathway 0 0.654150198 0 kegg kegg NA NA no no no no no no Amoebiasis Bacteroides 0 -0.468379447 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Amoebiasis Basal transcription factors 0 -0.541501976 -0.688288288 kegg kegg NA NA no no no no no no Amoebiasis Base excision repair -0.585217391 -0.490118577 -0.515572716 kegg kegg NA NA no no no no no no Amoebiasis beta-Alanine metabolism 0 -0.437747036 0 kegg kegg NA NA no no no no no no Amoebiasis Bile secretion 0.488695652 0 0.603861004 kegg kegg NA NA no no no no no no Amoebiasis Biosynthesis of amino acids 0 0.59486166 0.553410553 kegg kegg NA NA no no no no no no Amoebiasis Biosynthesis of cofactors 0 -0.535573123 0 kegg kegg NA NA no no no no no no Amoebiasis Butanoate metabolism 0 -0.884387352 -0.418790219 kegg kegg NA NA no no no no no no Amoebiasis Butyricimonas 0.510233077 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Amoebiasis C-type lectin receptor signaling pathway 0 0.636363636 0 kegg kegg NA NA no no no no no no Amoebiasis cAMP signaling pathway 0 0.56916996 0 yes kegg kegg NA NA no no no no up up Amoebiasis Carbohydrate digestion and absorption 0 0.414031621 0 kegg kegg NA NA no no no no no no Amoebiasis Cardiac muscle contraction 0 -0.545454545 0 kegg kegg NA NA no no no no no up Amoebiasis Cell cycle -0.649565217 -0.697628458 -0.587902188 kegg kegg NA NA no no no no no no Amoebiasis Cellular senescence 0.499130435 0.519762846 0 kegg kegg NA NA no no no no no no Amoebiasis cGMP-PKG signaling pathway 0 0.725296443 0 kegg kegg NA NA no no no no no no Amoebiasis Chagas disease 0.435652174 0.815217391 0.446846847 kegg kegg NA NA no no no no no no Amoebiasis Chemokine signaling pathway 0.572173913 0.75 0 kegg kegg NA NA no no no no no no Amoebiasis Circadian rhythm 0 -0.42687747 -0.630888031 kegg kegg NA NA no no no no no no Amoebiasis Citrate cycle (TCA cycle) -0.491304348 -0.865612648 -0.562676963 kegg kegg NA NA no no no no no no Amoebiasis Complement and coagulation cascades 0.449565217 0.677865613 0.615958816 kegg kegg NA NA no no no no no no Amoebiasis Cysteine and methionine metabolism -0.502608696 -0.862648221 -0.403861004 kegg kegg NA NA no no no no no no Amoebiasis Cytokine-cytokine receptor interaction 0.614782609 0 0 kegg kegg NA NA no no no no no no Amoebiasis DNA replication -0.664347826 -0.84486166 -0.742084942 kegg kegg NA NA no no no no no no Amoebiasis Drug metabolism - cytochrome P450 0 -0.789525692 0 kegg kegg NA NA no no no no no no Amoebiasis Drug metabolism - other enzymes 0 -0.756916996 0 kegg kegg NA NA no no no no no no Amoebiasis ECM-receptor interaction 0 -0.441699605 0 kegg kegg NA NA no no no no up up Amoebiasis EGFR tyrosine kinase inhibitor resistance -0.446086957 -0.707509881 -0.530759331 kegg kegg NA NA no no no no no no Amoebiasis Endocrine resistance 0 0 0.418532819 kegg kegg NA NA no no no no no no Amoebiasis Endocytosis 0.489565217 0.421936759 0 kegg kegg NA NA no no no no no no Amoebiasis Epithelial cell signaling in Helicobacter pylori infection 0.440869565 0.732213439 0 kegg kegg NA NA no no no no no no Amoebiasis Estrogen signaling pathway 0 -0.603754941 0 kegg kegg NA NA no no no no no no Amoebiasis Ether lipid metabolism 0 -0.48715415 -0.649420849 kegg kegg NA NA no no no no no no Amoebiasis Fanconi anemia pathway -0.697391304 -0.530632411 -0.634234234 kegg kegg NA NA no no no no no no Amoebiasis Fat digestion and absorption 0 0.605731225 0 yes kegg kegg NA NA no no no no up up Amoebiasis Fatty acid biosynthesis 0 0.738142292 0 kegg kegg NA NA no no no no no no Amoebiasis Fatty acid elongation 0 -0.43083004 0 kegg kegg NA NA no no no no no no Amoebiasis Fc epsilon RI signaling pathway 0 0.812252964 0 kegg kegg NA NA no no no no no no Amoebiasis Fc gamma R-mediated phagocytosis 0 0.566205534 0.578893179 kegg kegg NA NA no no no no no no Amoebiasis Ferroptosis 0 0.485177866 0 kegg kegg NA NA no no no no no no Amoebiasis Folate biosynthesis -0.733913043 -0.578063241 0 kegg kegg NA NA no no no no no no Amoebiasis GABAergic synapse 0 0.707509881 0.415958816 kegg kegg NA NA no no no no up up Amoebiasis Gap junction 0.446956522 0.468379447 0.683655084 kegg kegg NA NA no no no no no no Amoebiasis Glucagon signaling pathway 0 -0.565217391 0 kegg kegg NA NA no no no no no no Amoebiasis Glutamatergic synapse 0.599130435 0.671936759 0.653539254 kegg kegg NA NA no no no no up up Amoebiasis Glutathione metabolism 0 -0.457509881 0 kegg kegg NA NA no no no no no no Amoebiasis Glycerolipid metabolism 0 0 -0.616473616 kegg kegg NA NA no no no no no up Amoebiasis Glycerophospholipid metabolism 0 0 -0.699356499 kegg kegg NA NA no no no no no up Amoebiasis Glycolysis / Gluconeogenesis 0 -0.690711462 0 kegg kegg NA NA no no no no no no Amoebiasis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.497391304 0.70256917 0 kegg kegg NA NA no no no no no no Amoebiasis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.541501976 -0.565250965 kegg kegg NA NA no no no no no no Amoebiasis Glycosaminoglycan degradation 0 0.477272727 0 kegg kegg NA NA no no no no no up Amoebiasis Glycosphingolipid biosynthesis - ganglio series 0 -0.522727273 -0.401029601 kegg kegg NA NA no no no no no no Amoebiasis Glyoxylate and dicarboxylate metabolism 0 0.767786561 0.447619048 kegg kegg NA NA no no no no no no Amoebiasis GnRH secretion 0 0.416996047 0 kegg kegg NA NA no no no no up up Amoebiasis "Growth hormone synthesis, secretion and action" 0 0.495059289 0.45019305 kegg kegg NA NA no no no no no no Amoebiasis Hedgehog signaling pathway 0 -0.577075099 -0.581981982 kegg kegg NA NA no no no no no no Amoebiasis Hematopoietic cell lineage 0 -0.572134387 0 kegg kegg NA NA no no no no no no Amoebiasis HIF-1 signaling pathway 0 -0.683794466 -0.456628057 kegg kegg NA NA no no no no no no Amoebiasis Hippo signaling pathway 0 -0.511857708 0 kegg kegg NA NA no no no no no no Amoebiasis Hippo signaling pathway - multiple species 0 0.622529644 0 kegg kegg NA NA no no no no no no Amoebiasis Homologous recombination -0.562608696 0 -0.562419562 kegg kegg NA NA no no no no no no Amoebiasis Huntington disease 0 -0.541501976 0 kegg kegg NA NA no no no no no no Amoebiasis IL-17 signaling pathway 0 0.699604743 0.498841699 kegg kegg NA NA no no no no no no Amoebiasis Inflammatory mediator regulation of TRP channels 0 -0.489130435 0 kegg kegg NA NA no no no no no no Amoebiasis Inositol phosphate metabolism 0 0 -0.561647362 kegg kegg NA NA no no no no no no Amoebiasis Insulin resistance 0 0.583003953 0 kegg kegg NA NA no no no no no no Amoebiasis Insulin signaling pathway -0.483478261 -0.749011858 -0.622136422 kegg kegg NA NA no no no no no no Amoebiasis JAK-STAT signaling pathway 0 0.563241107 0 kegg kegg NA NA no no no no no no Amoebiasis Legionellosis 0 -0.501976285 0 kegg kegg NA NA no no no no no no Amoebiasis Leishmaniasis -0.426956522 -0.483201581 0 kegg kegg NA NA no no no no no no Amoebiasis Leukocyte transendothelial migration 0.426086957 0 0.555212355 kegg kegg NA NA no no no no no no Amoebiasis Long-term depression 0.53826087 0.428853755 0.57039897 kegg kegg NA NA no no no no no no Amoebiasis Long-term potentiation 0 -0.708498024 -0.428828829 kegg kegg NA NA no no no no no up Amoebiasis Lysine degradation -0.474782609 0 -0.707850708 kegg kegg NA NA no no no no no no Amoebiasis Lysosome 0 0.513833992 0 kegg kegg NA NA no no no no no no Amoebiasis Malaria 0 0.425889328 0 kegg kegg NA NA no no no no no no Amoebiasis Mannose type O-glycan biosynthesis 0 0 -0.643758044 kegg kegg NA NA no no no no no no Amoebiasis Maturity onset diabetes of the young 0 0 -0.535392535 kegg kegg NA NA no no no no up no Amoebiasis Melanogenesis 0 -0.4743083 0 kegg kegg NA NA no no no no no no Amoebiasis Metabolism of xenobiotics by cytochrome P450 0 -0.751976285 0 kegg kegg NA NA no no no no no no Amoebiasis Mismatch repair -0.619130435 -0.673913043 -0.412870013 kegg kegg NA NA no no no no no no Amoebiasis mRNA surveillance pathway 0 -0.637351779 -0.638352638 kegg kegg NA NA no no no no no no Amoebiasis mTOR signaling pathway -0.413913043 -0.716403162 -0.485199485 kegg kegg NA NA no no no no no no Amoebiasis N-Glycan biosynthesis -0.474782609 -0.809288538 -0.482368082 kegg kegg NA NA no no no no no no Amoebiasis Natural killer cell mediated cytotoxicity 0.46 0.445652174 0 kegg kegg NA NA no no no no no no Amoebiasis Neuroactive ligand-receptor interaction 0 0.449604743 0.482110682 kegg kegg NA NA no no no up up up Amoebiasis Neurotrophin signaling pathway 0 0.488142292 0 kegg kegg NA NA no no no no no no Amoebiasis Neutrophil extracellular trap formation 0 0.661067194 0.617760618 kegg kegg NA NA no no no no no no Amoebiasis NF-kappa B signaling pathway 0 0.694664032 0 kegg kegg NA NA no no no no no no Amoebiasis Nicotinate and nicotinamide metabolism 0 0.85770751 0 kegg kegg NA NA no no no no no no Amoebiasis Nitrogen metabolism 0.476521739 0.796442688 0.520720721 kegg kegg NA NA no no no no no no Amoebiasis NOD-like receptor signaling pathway 0 0.611660079 0 kegg kegg NA NA no no no no no no Amoebiasis Non-alcoholic fatty liver disease 0 -0.419960474 0 kegg kegg NA NA no no no no no no Amoebiasis Non-homologous end-joining 0 -0.590909091 0 kegg kegg NA NA no no no no no no Amoebiasis Notch signaling pathway 0 0 -0.627541828 kegg kegg NA NA no no no no no no Amoebiasis Nucleotide excision repair -0.682608696 -0.701581028 -0.581209781 kegg kegg NA NA no no no no no no Amoebiasis Olfactory transduction 0 0.580039526 0 kegg kegg NA NA no no no no no no Amoebiasis One carbon pool by folate -0.610434783 -0.671936759 -0.663577864 kegg kegg NA NA no no no no no no Amoebiasis Oocyte meiosis -0.409565217 -0.723320158 0 kegg kegg NA NA no no no no no no Amoebiasis Osteoclast differentiation 0 0.668972332 0.500643501 kegg kegg NA NA no no no no no no Amoebiasis Other glycan degradation 0 0 -0.417760618 kegg kegg NA NA no no no no no no Amoebiasis Other types of O-glycan biosynthesis -0.533043478 0 -0.64993565 kegg kegg NA NA no no no no no no Amoebiasis Ovarian steroidogenesis 0 0 0.628571429 kegg kegg NA NA no no no no up up Amoebiasis Oxidative phosphorylation 0 -0.532608696 0 kegg kegg NA NA no no no no no no Amoebiasis Oxytocin signaling pathway 0 0 0.617503218 kegg kegg NA NA no no no no no no Amoebiasis p53 signaling pathway 0 0 -0.509137709 kegg kegg NA NA no no no no no no Amoebiasis Pantothenate and CoA biosynthesis 0 0.70256917 0 kegg kegg NA NA no no no no no dn Amoebiasis Parkinson disease 0 -0.446640316 0 kegg kegg NA NA no no no no no no Amoebiasis Pathogenic Escherichia coli infection 0 0 0.545688546 kegg kegg NA NA no no no no no no Amoebiasis Pathways of neurodegeneration - multiple diseases 0 -0.469367589 0 kegg kegg NA NA no no no no no no Amoebiasis Pentose and glucuronate interconversions -0.496521739 -0.906126482 -0.549034749 kegg kegg NA NA no no no no no no Amoebiasis Pentose phosphate pathway 0 0.612648221 0.498069498 kegg kegg NA NA no no no no no no Amoebiasis Peroxisome 0 0.541501976 0 kegg kegg NA NA no no no no no no Amoebiasis Pertussis 0.525217391 0.648221344 0.671557272 kegg kegg NA NA no no no no no dn Amoebiasis Phagosome 0.475652174 0.421936759 0.491377091 kegg kegg NA NA no no no no no no Amoebiasis Phenylalanine metabolism 0 -0.663043478 0 kegg kegg NA NA no no no no no no Amoebiasis Phosphatidylinositol signaling system 0 -0.446640316 -0.617503218 kegg kegg NA NA no no no no no no Amoebiasis Phospholipase D signaling pathway 0.785217391 0.864624506 0.578635779 kegg kegg NA NA no no no no up up Amoebiasis Phototransduction 0 -0.532608696 0 kegg kegg NA NA no no no no no no Amoebiasis PI3K-Akt signaling pathway -0.512173913 0 -0.532561133 yes kegg kegg NA NA no no no no up up Amoebiasis Platelet activation 0 0 0.506048906 kegg kegg NA NA no no no no no no Amoebiasis PPAR signaling pathway 0 0.570158103 0.45019305 kegg kegg NA NA no no no no no no Amoebiasis Prevotella 0 0.413635022 0 acetate-producing kegg Genus NA 0.287 no no no no no no Amoebiasis Primary bile acid biosynthesis -0.58173913 -0.479249012 0 kegg kegg NA NA no no no no no no Amoebiasis Prion disease 0 -0.643280632 0 kegg kegg NA NA no no no no no no Amoebiasis Progesterone-mediated oocyte maturation 0 0 -0.481853282 kegg kegg NA NA no no no no no no Amoebiasis Prolactin signaling pathway 0.429565217 0.645256917 0 kegg kegg NA NA no no no no no no Amoebiasis Propanoate metabolism -0.431304348 -0.822134387 0 kegg kegg NA NA no no no no no no Amoebiasis Proteasome 0 -0.698616601 -0.471299871 kegg kegg NA NA no no no no no no Amoebiasis Protein export -0.453043478 -0.742094862 -0.612870013 kegg kegg NA NA no no no no no no Amoebiasis Protein processing in endoplasmic reticulum 0 -0.807312253 0 kegg kegg NA NA no no no no no no Amoebiasis Proximal tubule bicarbonate reclamation 0 -0.698616601 0 kegg kegg NA NA no no no no no no Amoebiasis Pyrimidine metabolism 0 -0.565217391 -0.503732304 kegg kegg NA NA no no no no no no Amoebiasis Pyruvate metabolism -0.537391304 -0.886363636 0 kegg kegg NA NA no no no no no no Amoebiasis Rap1 signaling pathway 0 0 0.521492921 kegg kegg NA NA no no no no no no Amoebiasis Ras signaling pathway 0 -0.612648221 -0.499356499 yes kegg kegg NA NA no no no no up up Amoebiasis Regulation of lipolysis in adipocytes 0.510434783 0 0.513256113 kegg kegg NA NA no no no no no no Amoebiasis Relaxin signaling pathway 0 0.66798419 0 kegg kegg NA NA no no no no no no Amoebiasis Renin secretion 0 -0.441699605 0 kegg kegg NA NA no no no no no no Amoebiasis Renin-angiotensin system 0 0.598814229 0 kegg kegg NA NA no no no no no no Amoebiasis Retinol metabolism 0 -0.494071146 -0.492149292 kegg kegg NA NA no no no no no no Amoebiasis Retrograde endocannabinoid signaling 0 -0.500988142 0 kegg kegg NA NA no no no no no up Amoebiasis Ribosome 0 -0.630434783 -0.41003861 kegg kegg NA NA no no no no no no Amoebiasis Ribosome biogenesis in eukaryotes -0.543478261 -0.720355731 -0.721750322 kegg kegg NA NA no no no no no no Amoebiasis RIG-I-like receptor signaling pathway 0 0.693675889 0 kegg kegg NA NA no no no no no no Amoebiasis RNA degradation 0 -0.811264822 -0.731016731 kegg kegg NA NA no no no no no no Amoebiasis RNA polymerase 0 -0.809288538 -0.708622909 kegg kegg NA NA no no no no no no Amoebiasis RNA transport -0.455652174 -0.757905138 0 kegg kegg NA NA no no no no no no Amoebiasis Salivary secretion 0.489565217 0 0.7003861 kegg kegg NA NA no no no no no no Amoebiasis Salmonella infection 0 0 0.506821107 kegg kegg NA NA no no no no no no Amoebiasis Selenocompound metabolism 0 0 -0.628056628 kegg kegg NA NA no no no no no no Amoebiasis Serotonergic synapse 0 0.494071146 0.773487773 kegg kegg NA NA no no no no no no Amoebiasis SNARE interactions in vesicular transport -0.592173913 0 0 kegg kegg NA NA no no no no no no Amoebiasis Spinocerebellar ataxia 0 -0.636363636 -0.729472329 kegg kegg NA NA no no no no no no Amoebiasis Spliceosome -0.413043478 0 -0.567052767 kegg kegg NA NA no no no no no no Amoebiasis Starch and sucrose metabolism 0 0.64229249 0 kegg kegg NA NA no no no no no no Amoebiasis Steroid biosynthesis 0 -0.537549407 -0.439124839 kegg kegg NA NA no no no no no no Amoebiasis Steroid hormone biosynthesis 0 -0.544466403 -0.474903475 kegg kegg NA NA no no no no no no Amoebiasis Synaptic vesicle cycle 0 0.605731225 0 kegg kegg NA NA no no no no up up Amoebiasis Synthesis and degradation of ketone bodies -0.552173913 -0.699604743 -0.487001287 kegg kegg NA NA no no no no no no Amoebiasis Taste transduction -0.509565217 -0.596837945 -0.691119691 kegg kegg NA NA no no no no no up Amoebiasis Taurine and hypotaurine metabolism 0 0 -0.408751609 kegg kegg NA NA no no no no no no Amoebiasis Terpenoid backbone biosynthesis -0.426956522 -0.45256917 -0.698584299 kegg kegg NA NA no no no no no no Amoebiasis TGF-beta signaling pathway 0 -0.681818182 -0.465637066 kegg kegg NA NA no no no no no no Amoebiasis Thermogenesis 0 -0.609683794 0 kegg kegg NA NA no no no no no no Amoebiasis Thiamine metabolism -0.595652174 -0.73715415 0 kegg kegg NA NA no no no no no no Amoebiasis TNF signaling pathway 0 0.597826087 0 kegg kegg NA NA no no no no no no Amoebiasis Toll-like receptor signaling pathway 0.446956522 0.755928854 0 yes kegg kegg NA NA no no no no no no Amoebiasis Tryptophan metabolism -0.424347826 -0.62944664 0 kegg kegg NA NA no no no no up no Amoebiasis Type II diabetes mellitus 0 0.514822134 0 kegg kegg NA NA no no no no no no Amoebiasis Tyrosine metabolism 0 -0.672924901 0 kegg kegg NA NA no no no no no no Amoebiasis Ubiquinone and other terpenoid-quinone biosynthesis -0.640869565 -0.644268775 -0.587644788 kegg kegg NA NA no no no no no no Amoebiasis Ubiquitin mediated proteolysis 0 -0.416996047 0 kegg kegg NA NA no no no no no no Amoebiasis "Valine, leucine and isoleucine degradation" -0.579130435 -0.795454545 -0.467438867 kegg kegg NA NA no no no no no no Amoebiasis Various types of N-glycan biosynthesis 0 -0.747035573 -0.421879022 kegg kegg NA NA no no no no no no Amoebiasis VEGF signaling pathway 0 0.551383399 0 kegg kegg NA NA no no no no no no Amoebiasis Vibrio cholerae infection 0 0 0.403346203 kegg kegg NA NA no no no no no no Amoebiasis Viral protein interaction with cytokine and cytokine receptor 0.587826087 0.503952569 0 kegg kegg NA NA no no no no no no Amoebiasis Wnt signaling pathway 0 -0.794466403 -0.66023166 kegg kegg NA NA no no no no no no Amoebiasis Yersinia infection 0 0.528656126 0 kegg kegg NA NA no no no no no no Amphetamine addiction ABC transporters -0.477391304 0 0 kegg kegg NA NA no no no no up up Amphetamine addiction Adrenergic signaling in cardiomyocytes 0.73826087 0.767786561 0.857657658 kegg kegg NA NA no no no no no up Amphetamine addiction AGE-RAGE signaling pathway in diabetic complications 0 -0.752964427 0 kegg kegg NA NA no no no no no no Amphetamine addiction "Alanine, aspartate and glutamate metabolism" -0.577391304 -0.662055336 -0.454054054 kegg kegg NA NA no no no no no no Amphetamine addiction Aldosterone synthesis and secretion 0.854782609 0.87944664 0.935907336 kegg kegg NA NA no no no no up up Amphetamine addiction Aldosterone-regulated sodium reabsorption 0 -0.432806324 0 kegg kegg NA NA no no no no no no Amphetamine addiction alpha-Linolenic acid metabolism -0.680869565 -0.538537549 -0.683397683 kegg kegg NA NA no no no no no no Amphetamine addiction Alzheimer disease 0.555652174 0.757905138 0 kegg kegg NA NA no no no no no no Amphetamine addiction Amino sugar and nucleotide sugar metabolism -0.414782609 0 -0.547232947 kegg kegg NA NA no no no no no no Amphetamine addiction AMPK signaling pathway 0 0.614624506 0 kegg kegg NA NA no no no no no no Amphetamine addiction Amyotrophic lateral sclerosis 0.613913043 0.806324111 0 kegg kegg NA NA no no no no no no Amphetamine addiction Antigen processing and presentation -0.444347826 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Apelin signaling pathway 0 0.624505929 0 kegg kegg NA NA no no no no no no Amphetamine addiction Apoptosis -0.58 -0.787549407 0 kegg kegg NA NA no no no no no no Amphetamine addiction Arginine and proline metabolism -0.549565217 -0.73715415 0 kegg kegg NA NA no no no no up no Amphetamine addiction Arginine biosynthesis -0.614782609 -0.685770751 -0.422136422 kegg kegg NA NA no no no no no no Amphetamine addiction Ascorbate and aldarate metabolism 0 0 -0.527413127 kegg kegg NA NA no no no no no no Amphetamine addiction Autophagy - animal 0 -0.579051383 0 kegg kegg NA NA no no no no no no Amphetamine addiction B cell receptor signaling pathway 0 -0.754940711 0 kegg kegg NA NA no no no no no no Amphetamine addiction Basal transcription factors 0 0.635375494 0 kegg kegg NA NA no no no no no no Amphetamine addiction beta-Alanine metabolism -0.493913043 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Bile secretion 0.710434783 0.546442688 0.56962677 kegg kegg NA NA no no no no no no Amphetamine addiction Biosynthesis of amino acids -0.717391304 -0.820158103 -0.489060489 kegg kegg NA NA no no no no no no Amphetamine addiction Biosynthesis of cofactors 0 0.688735178 0 kegg kegg NA NA no no no no no no Amphetamine addiction Butanoate metabolism 0 0.458498024 0 kegg kegg NA NA no no no no no no Amphetamine addiction C-type lectin receptor signaling pathway 0 -0.779644269 0 kegg kegg NA NA no no no no no no Amphetamine addiction Calcium signaling pathway 0.627826087 0.543478261 0.748262548 kegg kegg NA NA no no no no up up Amphetamine addiction cAMP signaling pathway 0.569565217 0 0.570656371 yes kegg kegg NA NA no no no no up up Amphetamine addiction Carbon metabolism -0.549565217 0 -0.57992278 kegg kegg NA NA no no no no no no Amphetamine addiction Cardiac muscle contraction 0.526956522 0.696640316 0 kegg kegg NA NA no no no no no up Amphetamine addiction Cell adhesion molecules -0.520869565 -0.78458498 0 kegg kegg NA NA no no no no no no Amphetamine addiction Cell cycle 0 0.658102767 0 kegg kegg NA NA no no no no no no Amphetamine addiction Cellular senescence -0.466956522 -0.750988142 0 kegg kegg NA NA no no no no no no Amphetamine addiction cGMP-PKG signaling pathway 0 -0.778656126 0 kegg kegg NA NA no no no no no no Amphetamine addiction Chemokine signaling pathway 0 -0.729249012 0 kegg kegg NA NA no no no no no no Amphetamine addiction Cholesterol metabolism 0 -0.555335968 -0.475160875 yes kegg kegg NA NA no no no no no up Amphetamine addiction Circadian entrainment 0.750434783 0.67687747 0.765765766 kegg kegg NA NA no no no no up up Amphetamine addiction Circadian rhythm 0.431304348 0.581027668 0 kegg kegg NA NA no no no no no no Amphetamine addiction Citrate cycle (TCA cycle) 0 0.456521739 0 kegg kegg NA NA no no no no no no Amphetamine addiction Cocaine addiction 0.70173913 0.583992095 0.79021879 kegg kegg NA NA no no no no no no Amphetamine addiction Complement and coagulation cascades -0.7 -0.781620553 0 kegg kegg NA NA no no no no no no Amphetamine addiction Coprococcus 0 0 -0.476993373 butyrate-producing kegg Genus NA 0.612 no no no no no no Amphetamine addiction Cortisol synthesis and secretion 0.745217391 0.645256917 0.804890605 kegg kegg NA NA no no no no no up Amphetamine addiction Cushing syndrome 0.776521739 0.73715415 0.754440154 kegg kegg NA NA no no no no no up Amphetamine addiction Cysteine and methionine metabolism 0 0.486166008 0 kegg kegg NA NA no no no no no no Amphetamine addiction DNA replication 0 0.619565217 0 kegg kegg NA NA no no no no no no Amphetamine addiction Dopaminergic synapse 0.831304348 0.765810277 0.923037323 kegg kegg NA NA no no no no up no Amphetamine addiction Dorea -0.450434783 0 0 kegg Genus NA 0.00362 no no no up no dn Amphetamine addiction Drug metabolism - cytochrome P450 0 0.568181818 0 kegg kegg NA NA no no no no no no Amphetamine addiction Drug metabolism - other enzymes -0.482608696 0.475296443 -0.482882883 kegg kegg NA NA no no no no no no Amphetamine addiction ECM-receptor interaction 0 0 0.487516088 kegg kegg NA NA no no no no up up Amphetamine addiction EGFR tyrosine kinase inhibitor resistance 0 0.531620553 0 kegg kegg NA NA no no no no no no Amphetamine addiction Endocrine and other factor-regulated calcium reabsorption 0.782608696 0.786561265 0.813899614 kegg kegg NA NA no no no no no no Amphetamine addiction Endocrine resistance 0.802608696 0.537549407 0.687516088 kegg kegg NA NA no no no no no no Amphetamine addiction Endocytosis -0.544347826 -0.782608696 0 kegg kegg NA NA no no no no no no Amphetamine addiction Estrogen signaling pathway 0.459130435 0.709486166 0.474131274 kegg kegg NA NA no no no no no no Amphetamine addiction Ether lipid metabolism 0.510434783 0.738142292 0 kegg kegg NA NA no no no no no no Amphetamine addiction Fanconi anemia pathway 0 0.448616601 0 kegg kegg NA NA no no no no no no Amphetamine addiction Fat digestion and absorption -0.57826087 -0.645256917 -0.671557272 yes kegg kegg NA NA no no no no up up Amphetamine addiction Fatty acid biosynthesis -0.546956522 -0.709486166 -0.505534106 kegg kegg NA NA no no no no no no Amphetamine addiction Fatty acid degradation -0.630434783 -0.579051383 -0.719433719 kegg kegg NA NA no no no no no no Amphetamine addiction Fatty acid metabolism -0.643478261 -0.598814229 -0.601544402 kegg kegg NA NA no no no no no no Amphetamine addiction Fc epsilon RI signaling pathway 0 -0.791501976 -0.455083655 kegg kegg NA NA no no no no no no Amphetamine addiction Fc gamma R-mediated phagocytosis -0.622608696 -0.790513834 -0.417503218 kegg kegg NA NA no no no no no no Amphetamine addiction Fructose and mannose metabolism -0.573043478 0 -0.653281853 kegg kegg NA NA no no no no no no Amphetamine addiction GABAergic synapse -0.43826087 -0.540513834 0 kegg kegg NA NA no no no no up up Amphetamine addiction Galactose metabolism -0.6 -0.624505929 -0.543114543 kegg kegg NA NA no no no no no no Amphetamine addiction Gap junction 0.58 0 0.503732304 kegg kegg NA NA no no no no no no Amphetamine addiction Gastric acid secretion 0 0.56916996 0 kegg kegg NA NA no no no no no no Amphetamine addiction Glucagon signaling pathway 0.842608696 0.940711462 0.764221364 kegg kegg NA NA no no no no no no Amphetamine addiction Glutamatergic synapse 0.44173913 0 0.415958816 kegg kegg NA NA no no no no up up Amphetamine addiction Glutathione metabolism 0 0.706521739 0 kegg kegg NA NA no no no no no no Amphetamine addiction Glycerolipid metabolism -0.472173913 0 0 kegg kegg NA NA no no no no no up Amphetamine addiction "Glycine, serine and threonine metabolism" 0 0.601778656 0 kegg kegg NA NA no no no no up no Amphetamine addiction Glycolysis / Gluconeogenesis -0.415652174 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.544347826 -0.574110672 0 kegg kegg NA NA no no no no no no Amphetamine addiction Glycosaminoglycan biosynthesis - keratan sulfate 0.472173913 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Glycosaminoglycan degradation -0.405217391 -0.527667984 -0.452252252 kegg kegg NA NA no no no no no up Amphetamine addiction Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.498023715 0 kegg kegg NA NA no no no no no no Amphetamine addiction Glyoxylate and dicarboxylate metabolism -0.702608696 -0.718379447 -0.526383526 kegg kegg NA NA no no no no no no Amphetamine addiction GnRH signaling pathway 0.807826087 0.683794466 0.949292149 kegg kegg NA NA no no no no no no Amphetamine addiction "Growth hormone synthesis, secretion and action" 0.482608696 0 0.553925354 kegg kegg NA NA no no no no no no Amphetamine addiction Hedgehog signaling pathway 0.475652174 0.433794466 0 kegg kegg NA NA no no no no no no Amphetamine addiction Hippo signaling pathway 0 0.445652174 0 kegg kegg NA NA no no no no no no Amphetamine addiction Hippo signaling pathway - multiple species 0 -0.56027668 -0.424710425 kegg kegg NA NA no no no no no no Amphetamine addiction Histidine metabolism 0 0 -0.655341055 kegg kegg NA NA no no no no no no Amphetamine addiction Huntington disease 0.556521739 0.774703557 0 kegg kegg NA NA no no no no no no Amphetamine addiction IL-17 signaling pathway -0.480869565 -0.726284585 -0.429086229 kegg kegg NA NA no no no no no no Amphetamine addiction Inflammatory mediator regulation of TRP channels 0.807826087 0.863636364 0.875933076 kegg kegg NA NA no no no no no no Amphetamine addiction Insulin resistance 0 -0.517786561 0 kegg kegg NA NA no no no no no no Amphetamine addiction Insulin secretion 0.747826087 0.677865613 0.832175032 yes kegg kegg NA NA no no no no up up Amphetamine addiction Insulin signaling pathway 0 0.571146245 0 kegg kegg NA NA no no no no no no Amphetamine addiction JAK-STAT signaling pathway 0 -0.4743083 0 kegg kegg NA NA no no no no no no Amphetamine addiction Long-term depression 0.66 0 0.716602317 kegg kegg NA NA no no no no no no Amphetamine addiction Long-term potentiation 0.466086957 0 0 kegg kegg NA NA no no no no no up Amphetamine addiction Lysosome -0.49826087 -0.697628458 -0.574259974 kegg kegg NA NA no no no no no no Amphetamine addiction Maturity onset diabetes of the young 0 0.514822134 0 kegg kegg NA NA no no no no up no Amphetamine addiction Melanogenesis 0.813913043 0.843873518 0.900900901 kegg kegg NA NA no no no no no no Amphetamine addiction Metabolism of xenobiotics by cytochrome P450 0 0.491106719 0 kegg kegg NA NA no no no no no no Amphetamine addiction Mineral absorption 0.565217391 0.421936759 0 kegg kegg NA NA no no no no no no Amphetamine addiction Mismatch repair 0 0.523715415 0 kegg kegg NA NA no no no no no no Amphetamine addiction Mitophagy - animal 0.593913043 0.668972332 0 kegg kegg NA NA no no no no no no Amphetamine addiction mRNA surveillance pathway 0.570434783 0.732213439 0 kegg kegg NA NA no no no no no no Amphetamine addiction mTOR signaling pathway 0 0.536561265 0 kegg kegg NA NA no no no no no no Amphetamine addiction N-Glycan biosynthesis 0.420869565 0.665019763 0 kegg kegg NA NA no no no no no no Amphetamine addiction Natural killer cell mediated cytotoxicity -0.52173913 -0.745059289 0 kegg kegg NA NA no no no no no no Amphetamine addiction Necroptosis 0.535652174 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Neuroactive ligand-receptor interaction -0.41826087 -0.730237154 -0.510682111 kegg kegg NA NA no no no up up up Amphetamine addiction Neurotrophin signaling pathway 0 -0.644268775 0 kegg kegg NA NA no no no no no no Amphetamine addiction Neutrophil extracellular trap formation -0.679130435 -0.742094862 0 kegg kegg NA NA no no no no no no Amphetamine addiction NF-kappa B signaling pathway -0.523478261 -0.654150198 0 kegg kegg NA NA no no no no no no Amphetamine addiction Nicotinate and nicotinamide metabolism -0.680869565 -0.697628458 -0.556499356 kegg kegg NA NA no no no no no no Amphetamine addiction Nitrogen metabolism -0.557391304 -0.616600791 0 kegg kegg NA NA no no no no no no Amphetamine addiction NOD-like receptor signaling pathway -0.726086957 -0.785573123 0 kegg kegg NA NA no no no no no no Amphetamine addiction Non-alcoholic fatty liver disease 0.585217391 0.729249012 0.414671815 kegg kegg NA NA no no no no no no Amphetamine addiction Nucleotide excision repair 0 0.630434783 0 kegg kegg NA NA no no no no no no Amphetamine addiction Olfactory transduction 0 -0.643280632 -0.53024453 kegg kegg NA NA no no no no no no Amphetamine addiction One carbon pool by folate 0 0.670948617 0 kegg kegg NA NA no no no no no no Amphetamine addiction Oocyte meiosis 0.467826087 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Osteoclast differentiation -0.71826087 -0.851778656 0 kegg kegg NA NA no no no no no no Amphetamine addiction Other glycan degradation -0.548695652 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Ovarian steroidogenesis 0.724347826 0.533596838 0.572458172 kegg kegg NA NA no no no no up up Amphetamine addiction Oxidative phosphorylation 0.54 0.73715415 0 kegg kegg NA NA no no no no no no Amphetamine addiction Pancreatic secretion 0.740869565 0.68972332 0.843500644 kegg kegg NA NA no no no no no no Amphetamine addiction Pantothenate and CoA biosynthesis -0.533913043 -0.675889328 -0.712483912 kegg kegg NA NA no no no no no dn Amphetamine addiction "Parathyroid hormone synthesis, secretion and action" 0.695652174 0.730237154 0.722522523 kegg kegg NA NA no no no no no no Amphetamine addiction Parkinson disease 0.677391304 0.745059289 0 kegg kegg NA NA no no no no no no Amphetamine addiction Pathways of neurodegeneration - multiple diseases 0.677391304 0.770750988 0 kegg kegg NA NA no no no no no no Amphetamine addiction Pentose and glucuronate interconversions 0 0.596837945 0 kegg kegg NA NA no no no no no no Amphetamine addiction Pentose phosphate pathway -0.670434783 -0.78458498 -0.558043758 kegg kegg NA NA no no no no no no Amphetamine addiction Peroxisome -0.68173913 -0.66798419 -0.504504505 kegg kegg NA NA no no no no no no Amphetamine addiction Phagosome -0.557391304 -0.796442688 0 kegg kegg NA NA no no no no no no Amphetamine addiction Phosphatidylinositol signaling system 0.503478261 0.414031621 0 kegg kegg NA NA no no no no no no Amphetamine addiction Phospholipase D signaling pathway 0 -0.444664032 0 kegg kegg NA NA no no no no up up Amphetamine addiction Phototransduction 0.451304348 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Porphyrin and chlorophyll metabolism 0 0.58201581 0 kegg kegg NA NA no no no no no no Amphetamine addiction PPAR signaling pathway -0.493913043 -0.807312253 0 kegg kegg NA NA no no no no no no Amphetamine addiction Prevotella 0 0 0.409397432 acetate-producing kegg Genus NA 0.287 no no no no no no Amphetamine addiction Prion disease 0.548695652 0.714426877 0 kegg kegg NA NA no no no no no no Amphetamine addiction Prolactin signaling pathway 0 -0.662055336 0 kegg kegg NA NA no no no no no no Amphetamine addiction Propanoate metabolism 0 0.441699605 0 kegg kegg NA NA no no no no no no Amphetamine addiction Proteasome 0 0 -0.422908623 kegg kegg NA NA no no no no no no Amphetamine addiction Protein digestion and absorption -0.556521739 -0.643280632 -0.461003861 yes kegg kegg NA NA no no no no up up Amphetamine addiction Protein export 0.566956522 0.612648221 0 kegg kegg NA NA no no no no no no Amphetamine addiction Protein processing in endoplasmic reticulum 0.568695652 0.726284585 0 kegg kegg NA NA no no no no no no Amphetamine addiction Proximal tubule bicarbonate reclamation 0 0.603754941 0 kegg kegg NA NA no no no no no no Amphetamine addiction Purine metabolism 0 0.633399209 0 kegg kegg NA NA no no no no no no Amphetamine addiction Pyrimidine metabolism -0.443478261 0.583992095 0 kegg kegg NA NA no no no no no no Amphetamine addiction Pyruvate metabolism 0 0.60770751 0 kegg kegg NA NA no no no no no no Amphetamine addiction Ras signaling pathway 0 0.490118577 0 yes kegg kegg NA NA no no no no up up Amphetamine addiction Regulation of lipolysis in adipocytes 0.70173913 0.483201581 0.712741313 kegg kegg NA NA no no no no no no Amphetamine addiction Relaxin signaling pathway 0 0 0.522779923 kegg kegg NA NA no no no no no no Amphetamine addiction Renin secretion 0.717391304 0.84486166 0.764221364 kegg kegg NA NA no no no no no no Amphetamine addiction Renin-angiotensin system -0.519130435 -0.791501976 -0.536422136 kegg kegg NA NA no no no no no no Amphetamine addiction Retrograde endocannabinoid signaling 0 0.671936759 0 kegg kegg NA NA no no no no no up Amphetamine addiction Ribosome 0.584347826 0.650197628 0 kegg kegg NA NA no no no no no no Amphetamine addiction Ribosome biogenesis in eukaryotes 0 0.636363636 0 kegg kegg NA NA no no no no no no Amphetamine addiction RIG-I-like receptor signaling pathway 0 -0.674901186 0 kegg kegg NA NA no no no no no no Amphetamine addiction RNA degradation 0.517391304 0.705533597 0 kegg kegg NA NA no no no no no no Amphetamine addiction RNA polymerase 0 0.774703557 0 kegg kegg NA NA no no no no no no Amphetamine addiction Ruminococcus 0.551304348 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Amphetamine addiction Salivary secretion 0 0 0.516087516 kegg kegg NA NA no no no no no no Amphetamine addiction Sarcina 0 -0.422326513 0 kegg Genus NA 0.0703 no no no no no no Amphetamine addiction Serotonergic synapse 0.548695652 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction SNARE interactions in vesicular transport 0 -0.476284585 0 kegg kegg NA NA no no no no no no Amphetamine addiction Sphingolipid metabolism 0 0 -0.473616474 kegg kegg NA NA no no no no no no Amphetamine addiction Sphingolipid signaling pathway 0 -0.639328063 0 kegg kegg NA NA no no no no no no Amphetamine addiction Spinocerebellar ataxia 0 0.446640316 0 kegg kegg NA NA no no no no no no Amphetamine addiction Starch and sucrose metabolism -0.674782609 -0.662055336 -0.688545689 kegg kegg NA NA no no no no no no Amphetamine addiction Steroid biosynthesis 0.628695652 0.499011858 0 kegg kegg NA NA no no no no no no Amphetamine addiction Steroid hormone biosynthesis 0 0.453557312 -0.412612613 kegg kegg NA NA no no no no no no Amphetamine addiction Synaptic vesicle cycle 0 -0.678853755 -0.672329472 kegg kegg NA NA no no no no up up Amphetamine addiction Synthesis and degradation of ketone bodies 0 0.541501976 0 kegg kegg NA NA no no no no no no Amphetamine addiction T cell receptor signaling pathway 0 -0.531620553 0 kegg kegg NA NA no no no no no no Amphetamine addiction Taste transduction 0 0.603754941 0 kegg kegg NA NA no no no no no up Amphetamine addiction TGF-beta signaling pathway 0.463478261 0.552371542 0 kegg kegg NA NA no no no no no no Amphetamine addiction Th1 and Th2 cell differentiation 0 -0.531620553 0 kegg kegg NA NA no no no no no no Amphetamine addiction Th17 cell differentiation 0 -0.545454545 0 kegg kegg NA NA no no no no no no Amphetamine addiction Thermogenesis 0.630434783 0.758893281 0 kegg kegg NA NA no no no no no no Amphetamine addiction Thiamine metabolism 0 0.493083004 0 kegg kegg NA NA no no no no no no Amphetamine addiction Thyroid hormone signaling pathway 0 0.429841897 0 kegg kegg NA NA no no no no no no Amphetamine addiction Thyroid hormone synthesis 0.671304348 0.654150198 0.626254826 kegg kegg NA NA no no no no no no Amphetamine addiction TNF signaling pathway 0 -0.653162055 0 kegg kegg NA NA no no no no no no Amphetamine addiction Toll-like receptor signaling pathway 0 -0.801383399 0 yes kegg kegg NA NA no no no no no no Amphetamine addiction Type I diabetes mellitus -0.426086957 -0.688735178 0 kegg kegg NA NA no no no no no no Amphetamine addiction Type II diabetes mellitus 0 -0.414031621 0 kegg kegg NA NA no no no no no no Amphetamine addiction Tyrosine metabolism 0 0.579051383 0 kegg kegg NA NA no no no no no no Amphetamine addiction Ubiquinone and other terpenoid-quinone biosynthesis 0 0.421936759 0 kegg kegg NA NA no no no no no no Amphetamine addiction Ubiquitin mediated proteolysis 0.677391304 0.774703557 0 kegg kegg NA NA no no no no no no Amphetamine addiction "Valine, leucine and isoleucine degradation" 0 0.5 0 kegg kegg NA NA no no no no no no Amphetamine addiction Various types of N-glycan biosynthesis 0 0.445652174 0 kegg kegg NA NA no no no no no no Amphetamine addiction Vascular smooth muscle contraction 0.708695652 0.685770751 0.754697555 kegg kegg NA NA no no no no no no Amphetamine addiction Vasopressin-regulated water reabsorption 0.862608696 0.76284585 0.783783784 kegg kegg NA NA no no no no no no Amphetamine addiction VEGF signaling pathway 0 -0.583003953 0 kegg kegg NA NA no no no no no no Amphetamine addiction Vitamin digestion and absorption 0.504347826 0 0 kegg kegg NA NA no no no no no no Amphetamine addiction Wnt signaling pathway 0.535652174 0.712450593 0 kegg kegg NA NA no no no no no no AMPK signaling pathway 2-Oxocarboxylic acid metabolism 0 0 -0.475933076 kegg kegg NA NA no no no no no no AMPK signaling pathway alpha-Linolenic acid metabolism 0 -0.460474308 -0.526640927 kegg kegg NA NA no no no no no no AMPK signaling pathway Arginine and proline metabolism -0.471304348 0 0 kegg kegg NA NA no no no no up no AMPK signaling pathway Ascorbate and aldarate metabolism 0 0 -0.411583012 kegg kegg NA NA no no no no no no AMPK signaling pathway Basal transcription factors 0 0.462450593 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Biosynthesis of amino acids 0 -0.470355731 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Biosynthesis of cofactors 0.54 0.66798419 0.712483912 kegg kegg NA NA no no no no no no AMPK signaling pathway Calcium signaling pathway 0 0.438735178 0 kegg kegg NA NA no no no no up up AMPK signaling pathway Carbon metabolism 0 -0.498023715 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Cell cycle 0 0.509881423 0 kegg kegg NA NA no no no no no no AMPK signaling pathway cGMP-PKG signaling pathway -0.554782609 -0.57312253 -0.522522523 kegg kegg NA NA no no no no no no AMPK signaling pathway Citrate cycle (TCA cycle) 0 0 -0.435778636 kegg kegg NA NA no no no no no no AMPK signaling pathway Clostridium -0.445456364 -0.424841882 0 kegg Genus NA 0.925 no no no no no no AMPK signaling pathway Cytokine-cytokine receptor interaction 0 -0.420948617 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Drug metabolism - cytochrome P450 0 0 -0.410553411 kegg kegg NA NA no no no no no no AMPK signaling pathway Drug metabolism - other enzymes 0 0 -0.552380952 kegg kegg NA NA no no no no no no AMPK signaling pathway EGFR tyrosine kinase inhibitor resistance 0 0.424901186 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Eggerthella 0 0.467400551 0 kegg Genus NA 0.912 no no no no no no AMPK signaling pathway Endocrine resistance 0 0.579051383 0.484684685 kegg kegg NA NA no no no no no no AMPK signaling pathway Endocytosis 0 -0.648221344 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Ether lipid metabolism 0 0.494071146 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Fatty acid biosynthesis -0.453043478 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Fatty acid metabolism -0.410434783 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Galactose metabolism 0 -0.517786561 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Glutathione metabolism 0.61826087 0.605731225 0.644787645 kegg kegg NA NA no no no no no no AMPK signaling pathway Glycerolipid metabolism 0 0 -0.558558559 kegg kegg NA NA no no no no no up AMPK signaling pathway Glycerophospholipid metabolism 0 0 -0.43989704 kegg kegg NA NA no no no no no up AMPK signaling pathway "Glycine, serine and threonine metabolism" 0.633043478 0.725296443 0.759330759 kegg kegg NA NA no no no no up no AMPK signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0 -0.515057915 kegg kegg NA NA no no no no no no AMPK signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.592020592 kegg kegg NA NA no no no no no no AMPK signaling pathway Glycosaminoglycan degradation 0 -0.688735178 -0.747232947 kegg kegg NA NA no no no no no up AMPK signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.59486166 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Histidine metabolism 0 -0.500988142 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Lysosome 0 -0.696640316 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Mannose type O-glycan biosynthesis 0 0 -0.408236808 kegg kegg NA NA no no no no no no AMPK signaling pathway Mitophagy - animal 0.545217391 0.650197628 0.711711712 kegg kegg NA NA no no no no no no AMPK signaling pathway mRNA surveillance pathway 0 0.54743083 0 kegg kegg NA NA no no no no no no AMPK signaling pathway mTOR signaling pathway 0 0.462450593 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Neuroactive ligand-receptor interaction -0.525217391 -0.645256917 0 kegg kegg NA NA no no no up up up AMPK signaling pathway NF-kappa B signaling pathway -0.413043478 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Nicotinate and nicotinamide metabolism -0.42 -0.437747036 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Other glycan degradation 0 0 -0.64967825 kegg kegg NA NA no no no no no no AMPK signaling pathway Other types of O-glycan biosynthesis 0 0.480237154 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Pantothenate and CoA biosynthesis -0.62173913 -0.608695652 0 kegg kegg NA NA no no no no no dn AMPK signaling pathway Pentose and glucuronate interconversions 0 0 -0.472329472 kegg kegg NA NA no no no no no no AMPK signaling pathway Pentose phosphate pathway 0 -0.658102767 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Peroxisome -0.424347826 -0.428853755 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Phagosome 0 -0.727272727 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Porphyrin and chlorophyll metabolism 0.684347826 0.705533597 0.761904762 kegg kegg NA NA no no no no no no AMPK signaling pathway PPAR signaling pathway -0.529565217 0 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Proteasome 0 0 -0.425482625 kegg kegg NA NA no no no no no no AMPK signaling pathway Protein processing in endoplasmic reticulum 0.502608696 0.54743083 0.545173745 kegg kegg NA NA no no no no no no AMPK signaling pathway Purine metabolism 0.836521739 0.768774704 0.678507079 kegg kegg NA NA no no no no no no AMPK signaling pathway Ribosome biogenesis in eukaryotes 0 0.427865613 0 kegg kegg NA NA no no no no no no AMPK signaling pathway RNA polymerase 0 0.479249012 0 kegg kegg NA NA no no no no no no AMPK signaling pathway SNARE interactions in vesicular transport 0 0 -0.554440154 kegg kegg NA NA no no no no no no AMPK signaling pathway Sphingolipid metabolism 0 -0.431818182 -0.501673102 kegg kegg NA NA no no no no no no AMPK signaling pathway Sphingolipid signaling pathway 0 0 -0.511454311 kegg kegg NA NA no no no no no no AMPK signaling pathway Starch and sucrose metabolism -0.411304348 -0.53458498 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Steroid hormone biosynthesis 0 0 -0.41029601 kegg kegg NA NA no no no no no no AMPK signaling pathway Sulfur metabolism 0.489565217 0 0.577863578 kegg kegg NA NA no no no no no no AMPK signaling pathway Thiamine metabolism 0 0.447628458 0 kegg kegg NA NA no no no no no no AMPK signaling pathway Ubiquitin mediated proteolysis 0.584347826 0.672924901 0.706048906 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis 2-Oxocarboxylic acid metabolism -0.480869565 0.46541502 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis ABC transporters -0.410434783 0 0 kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis Adherens junction 0 0.661067194 0.629343629 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Adrenergic signaling in cardiomyocytes 0.730434783 0.838932806 0.423166023 kegg kegg NA NA no no no no no up Amyotrophic lateral sclerosis AGE-RAGE signaling pathway in diabetic complications 0 -0.876482213 -0.488803089 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis "Alanine, aspartate and glutamate metabolism" -0.616521739 -0.837944664 -0.576833977 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Aldosterone synthesis and secretion 0.626086957 0.792490119 0.408751609 kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis alpha-Linolenic acid metabolism -0.629565217 -0.738142292 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Alzheimer disease 0.967826087 0.975296443 0.937709138 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Amino sugar and nucleotide sugar metabolism -0.593913043 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Aminoacyl-tRNA biosynthesis -0.573913043 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis AMPK signaling pathway 0 0.462450593 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Apelin signaling pathway 0 0.722332016 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Apoptosis -0.44173913 -0.630434783 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Arginine and proline metabolism -0.450434783 -0.851778656 -0.652252252 kegg kegg NA NA no no no no up no Amyotrophic lateral sclerosis Arginine biosynthesis -0.639130435 -0.803359684 -0.533590734 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Autophagy - animal 0 -0.747035573 -0.514800515 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Axon guidance 0.497391304 0 0 kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis B cell receptor signaling pathway 0 -0.673913043 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Bacteroides -0.409565217 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Amyotrophic lateral sclerosis beta-Alanine metabolism -0.69826087 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Bile secretion 0.482608696 0.463438735 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Biosynthesis of amino acids -0.807826087 -0.731225296 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Biosynthesis of cofactors 0 0.450592885 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Biosynthesis of unsaturated fatty acids -0.43826087 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Butanoate metabolism -0.539130435 0.434782609 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis C-type lectin receptor signaling pathway 0 -0.683794466 -0.479279279 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Calcium signaling pathway 0.723478261 0.72826087 0 kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis cAMP signaling pathway 0.762608696 0 0 yes kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis Carbohydrate digestion and absorption 0 -0.470355731 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Carbon metabolism -0.723478261 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Cardiac muscle contraction 0.963478261 0.956521739 0.944401544 kegg kegg NA NA no no no no no up Amyotrophic lateral sclerosis Cell adhesion molecules -0.544347826 -0.471343874 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Cell cycle 0 0.494071146 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Cellular senescence 0 -0.467391304 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis cGMP-PKG signaling pathway 0 -0.748023715 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Chemokine signaling pathway 0 -0.578063241 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Cholinergic synapse 0 -0.483201581 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Circadian entrainment 0 0.568181818 0 kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis Circadian rhythm 0.630434783 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Citrate cycle (TCA cycle) 0 0.490118577 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Complement and coagulation cascades -0.622608696 -0.739130435 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Cortisol synthesis and secretion 0.444347826 0.425889328 0 kegg kegg NA NA no no no no no up Amyotrophic lateral sclerosis Cushing syndrome 0.526086957 0.510869565 0 kegg kegg NA NA no no no no no up Amyotrophic lateral sclerosis Cysteine and methionine metabolism 0 0.479249012 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Cytokine-cytokine receptor interaction 0 -0.504940711 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis DNA replication 0 0.543478261 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Dopaminergic synapse 0.656521739 0.707509881 0 kegg kegg NA NA no no no no up no Amyotrophic lateral sclerosis Drug metabolism - cytochrome P450 0 0.583992095 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Drug metabolism - other enzymes -0.583478261 0.62055336 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis EGFR tyrosine kinase inhibitor resistance 0 0.636363636 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Endocrine and other factor-regulated calcium reabsorption 0.566956522 0.801383399 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Endocrine resistance 0.451304348 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Endocytosis -0.49826087 -0.509881423 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis ErbB signaling pathway 0 -0.431818182 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Estrogen signaling pathway 0 0.463438735 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Ether lipid metabolism 0.755652174 0.571146245 0.426512227 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Fat digestion and absorption -0.605217391 -0.693675889 0 yes kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis Fatty acid biosynthesis -0.548695652 -0.878458498 -0.672329472 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Fatty acid degradation -0.730434783 -0.845849802 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Fatty acid elongation -0.503478261 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Fatty acid metabolism -0.819130435 -0.847826087 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Fc epsilon RI signaling pathway 0 -0.757905138 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Fc gamma R-mediated phagocytosis -0.54 -0.721343874 -0.473101673 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Focal adhesion 0 0.528656126 0.518918919 kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis Folate biosynthesis 0 0.542490119 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis FoxO signaling pathway 0 -0.734189723 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Fructose and mannose metabolism -0.716521739 -0.496047431 -0.456885457 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis GABAergic synapse -0.462608696 -0.7243083 -0.433462033 kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis Galactose metabolism -0.732173913 -0.755928854 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Gastric acid secretion 0 0.739130435 0.614414414 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Glucagon signaling pathway 0.454782609 0.81027668 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Glutathione metabolism 0 0.673913043 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Glycerolipid metabolism 0 -0.528656126 0 kegg kegg NA NA no no no no no up Amyotrophic lateral sclerosis "Glycine, serine and threonine metabolism" 0 0.425889328 0 kegg kegg NA NA no no no no up no Amyotrophic lateral sclerosis Glycolysis / Gluconeogenesis -0.615652174 0.41798419 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.42173913 -0.732213439 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Glycosaminoglycan biosynthesis - keratan sulfate 0.580869565 0.443675889 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Glyoxylate and dicarboxylate metabolism -0.739130435 -0.817193676 -0.603603604 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis GnRH signaling pathway 0.41826087 0.489130435 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Hedgehog signaling pathway 0.489565217 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis HIF-1 signaling pathway 0 0.592885375 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Hippo signaling pathway 0 0.686758893 0.650965251 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Hippo signaling pathway - multiple species 0 -0.743083004 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis IL-17 signaling pathway 0 -0.650197628 -0.546203346 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Inflammatory mediator regulation of TRP channels 0.553043478 0.827075099 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Insulin resistance 0 -0.552371542 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Insulin secretion 0.42173913 0.553359684 0 yes kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis Insulin signaling pathway 0 0.658102767 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis JAK-STAT signaling pathway 0 -0.719367589 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Long-term depression 0.58173913 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Lysosome 0 -0.476284585 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Mannose type O-glycan biosynthesis 0.52173913 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis MAPK signaling pathway 0 -0.628458498 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Melanogenesis 0.572173913 0.860671937 0.404890605 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Metabolism of xenobiotics by cytochrome P450 0 0.533596838 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Mineral absorption 0.446086957 0.557312253 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Mitophagy - animal 0.593043478 0.778656126 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis mRNA surveillance pathway 0.73826087 0.734189723 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis mTOR signaling pathway 0 0.62944664 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis N-Glycan biosynthesis 0 0.674901186 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Natural killer cell mediated cytotoxicity -0.470434783 -0.467391304 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Neuroactive ligand-receptor interaction 0 -0.567193676 0 kegg kegg NA NA no no no up up up Amyotrophic lateral sclerosis Neurotrophin signaling pathway 0.525217391 -0.424901186 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Neutrophil extracellular trap formation -0.534782609 -0.612648221 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis NF-kappa B signaling pathway 0 -0.727272727 -0.51969112 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Nicotinate and nicotinamide metabolism -0.546086957 -0.822134387 -0.58018018 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Nitrogen metabolism -0.524347826 -0.7243083 -0.492921493 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis NOD-like receptor signaling pathway -0.433913043 -0.81027668 -0.503217503 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Non-alcoholic fatty liver disease 0.963478261 0.934782609 0.902702703 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Non-homologous end-joining -0.616521739 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Nucleotide excision repair 0 0.425889328 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Olfactory transduction 0 -0.686758893 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis One carbon pool by folate 0 0.43083004 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Oocyte meiosis 0.409565217 0.461462451 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Osteoclast differentiation 0 -0.807312253 -0.514028314 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Oxidative phosphorylation 0.973913043 0.970355731 0.950836551 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Pancreatic secretion 0.704347826 0.736166008 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Pantothenate and CoA biosynthesis -0.427826087 -0.842885375 -0.522522523 kegg kegg NA NA no no no no no dn Amyotrophic lateral sclerosis "Parathyroid hormone synthesis, secretion and action" 0.731304348 0.744071146 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Parkinson disease 0.879130435 0.935770751 0.450707851 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Pentose and glucuronate interconversions 0 0.630434783 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Pentose phosphate pathway -0.506086957 -0.650197628 -0.471814672 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Peroxisome -0.684347826 -0.779644269 -0.42960103 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Phagosome -0.590434783 -0.516798419 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Phosphatidylinositol signaling system 0.533043478 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Phospholipase D signaling pathway 0 -0.544466403 0 kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis Phototransduction 0 0.496047431 0.474646075 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Platelet activation 0 0.530632411 0.441441441 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Porphyrin and chlorophyll metabolism 0 0.443675889 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis PPAR signaling pathway 0 -0.678853755 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Prolactin signaling pathway 0 -0.685770751 -0.491119691 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Propanoate metabolism 0 0.434782609 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Proteasome 0 0.532608696 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Protein digestion and absorption -0.732173913 -0.811264822 -0.471042471 yes kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis Protein export 0.556521739 0.805335968 0.424967825 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Protein processing in endoplasmic reticulum 0 0.718379447 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Proximal tubule bicarbonate reclamation 0 0.562252964 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Purine metabolism 0 0.495059289 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Pyrimidine metabolism -0.755652174 0.456521739 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Pyruvate metabolism 0 0.585968379 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Rap1 signaling pathway 0 0.41798419 0.425740026 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Ras signaling pathway 0 0.576086957 0 yes kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis Regulation of actin cytoskeleton 0 0 0.437580438 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Relaxin signaling pathway 0.571304348 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Renin secretion 0 0.83201581 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Renin-angiotensin system 0 -0.674901186 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Retinol metabolism -0.506086957 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Retrograde endocannabinoid signaling 0.766086957 0.881422925 0.741312741 kegg kegg NA NA no no no no no up Amyotrophic lateral sclerosis Ribosome 0.746086957 0.821146245 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Ribosome biogenesis in eukaryotes 0 0.437747036 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis RIG-I-like receptor signaling pathway 0 -0.707509881 -0.503474903 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis RNA degradation 0.703478261 0.747035573 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis RNA polymerase 0 0.637351779 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis RNA transport 0 0.528656126 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Signaling pathways regulating pluripotency of stem cells 0.574782609 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis SNARE interactions in vesicular transport 0 -0.590909091 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Starch and sucrose metabolism -0.525217391 -0.846837945 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Steroid biosynthesis 0 0 0.41029601 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Synaptic vesicle cycle 0 -0.649209486 0 kegg kegg NA NA no no no no up up Amyotrophic lateral sclerosis T cell receptor signaling pathway 0 -0.490118577 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis TGF-beta signaling pathway 0.713043478 0.670948617 0.403088803 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Thermogenesis 0.979130435 0.970355731 0.908108108 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Thiamine metabolism 0 0.440711462 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Thyroid hormone signaling pathway 0 0.663043478 0.623166023 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Thyroid hormone synthesis 0 0.609683794 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Tight junction 0 0.526679842 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis TNF signaling pathway 0 -0.579051383 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Toll-like receptor signaling pathway 0 -0.722332016 0 yes kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Tryptophan metabolism -0.527826087 0 0 kegg kegg NA NA no no no no up no Amyotrophic lateral sclerosis Type I diabetes mellitus -0.455652174 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Type II diabetes mellitus 0 -0.618577075 -0.434491634 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Ubiquitin mediated proteolysis 0.615652174 0.829051383 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis "Valine, leucine and isoleucine degradation" -0.426956522 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Various types of N-glycan biosynthesis 0 0.472332016 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Vascular smooth muscle contraction 0.740869565 0.849802372 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Vasopressin-regulated water reabsorption 0.619130435 0.760869565 0.444787645 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis VEGF signaling pathway 0 -0.473320158 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Vitamin digestion and absorption 0.588695652 0 0 kegg kegg NA NA no no no no no no Amyotrophic lateral sclerosis Wnt signaling pathway 0.76 0.744071146 0.413642214 kegg kegg NA NA no no no no no no Anaerococcus Alloscardovia 0 0 0.436661287 Genus Genus 0.275 0.525 no no no no no no Anaerococcus Myroides 0 0.460720254 0 Genus Genus 0.275 0.269 no no no no no no Anaerotruncus Eggerthella 0.487088644 0 0 Genus Genus 0.904 0.912 no no no no no no Antifolate resistance 2-Oxocarboxylic acid metabolism 0 0.533596838 0 kegg kegg NA NA no no no no no no Antifolate resistance Amino sugar and nucleotide sugar metabolism 0 0.422924901 0.412097812 kegg kegg NA NA no no no no no no Antifolate resistance Aminoacyl-tRNA biosynthesis 0.512173913 0.611660079 0 kegg kegg NA NA no no no no no no Antifolate resistance Ascorbate and aldarate metabolism 0.513913043 0 0.422908623 kegg kegg NA NA no no no no no no Antifolate resistance Biosynthesis of amino acids 0 -0.464426877 -0.404633205 kegg kegg NA NA no no no no no no Antifolate resistance Biosynthesis of cofactors 0 0.471343874 0 kegg kegg NA NA no no no no no no Antifolate resistance Butanoate metabolism 0.506956522 0.493083004 0 kegg kegg NA NA no no no no no no Antifolate resistance Drug metabolism - cytochrome P450 0 0.445652174 0 kegg kegg NA NA no no no no no no Antifolate resistance Endocrine resistance 0 0.52173913 0 kegg kegg NA NA no no no no no no Antifolate resistance Ether lipid metabolism 0 0 0.571943372 kegg kegg NA NA no no no no no no Antifolate resistance Folate biosynthesis 0 0 0.42960103 kegg kegg NA NA no no no no no no Antifolate resistance Glycerolipid metabolism 0.503478261 0 0.517117117 kegg kegg NA NA no no no no no up Antifolate resistance Glycerophospholipid metabolism 0.477391304 0 0.57966538 kegg kegg NA NA no no no no no up Antifolate resistance Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.624505929 0 kegg kegg NA NA no no no no no no Antifolate resistance Glycosaminoglycan degradation -0.429565217 -0.530632411 0 kegg kegg NA NA no no no no no up Antifolate resistance Glycosphingolipid biosynthesis - ganglio series 0 0.568181818 0.453796654 kegg kegg NA NA no no no no no no Antifolate resistance Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.515652174 0.442687747 0 kegg kegg NA NA no no no no no no Antifolate resistance Histidine metabolism 0.466086957 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Inositol phosphate metabolism 0.585217391 0.481225296 0.515572716 kegg kegg NA NA no no no no no no Antifolate resistance Linoleic acid metabolism 0 0.540513834 0 kegg kegg NA NA no no no no no no Antifolate resistance Lysine degradation 0 0.549407115 0.542857143 kegg kegg NA NA no no no no no no Antifolate resistance Mannose type O-glycan biosynthesis 0 0 0.528442728 kegg kegg NA NA no no no no no no Antifolate resistance N-Glycan biosynthesis 0 0.5256917 0 kegg kegg NA NA no no no no no no Antifolate resistance One carbon pool by folate 0.619130435 0.77173913 0.512741313 kegg kegg NA NA no no no no no no Antifolate resistance Other glycan degradation 0 0 0.406177606 kegg kegg NA NA no no no no no no Antifolate resistance Other types of O-glycan biosynthesis 0.405217391 0.597826087 0.587644788 kegg kegg NA NA no no no no no no Antifolate resistance Pentose and glucuronate interconversions 0.417391304 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Pentose phosphate pathway 0 -0.5 0 kegg kegg NA NA no no no no no no Antifolate resistance Phenylalanine metabolism 0.488695652 0.495059289 0 kegg kegg NA NA no no no no no no Antifolate resistance Propanoate metabolism 0.419130435 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Pyrimidine metabolism 0 0.662055336 0 kegg kegg NA NA no no no no no no Antifolate resistance Pyruvate metabolism 0.540869565 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Retinol metabolism 0 0.749011858 0 kegg kegg NA NA no no no no no no Antifolate resistance Selenocompound metabolism 0 0.625494071 0.4998713 kegg kegg NA NA no no no no no no Antifolate resistance Sphingolipid metabolism -0.485217391 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Steroid hormone biosynthesis 0 0.485177866 0 kegg kegg NA NA no no no no no no Antifolate resistance Synthesis and degradation of ketone bodies 0.468695652 0.570158103 0 kegg kegg NA NA no no no no no no Antifolate resistance Terpenoid backbone biosynthesis 0 0 0.540797941 kegg kegg NA NA no no no no no no Antifolate resistance Thiamine metabolism 0.447826087 0 0 kegg kegg NA NA no no no no no no Antifolate resistance Tryptophan metabolism 0.515652174 0 0 kegg kegg NA NA no no no no up no Antifolate resistance Tyrosine metabolism 0.47826087 0.599802372 0 kegg kegg NA NA no no no no no no Antifolate resistance Ubiquinone and other terpenoid-quinone biosynthesis 0.58173913 0.605731225 0.497554698 kegg kegg NA NA no no no no no no Antifolate resistance "Valine, leucine and isoleucine degradation" 0.555652174 0.514822134 0 kegg kegg NA NA no no no no no no Antifolate resistance Various types of N-glycan biosynthesis 0 0.518774704 0 kegg kegg NA NA no no no no no no Antigen processing and presentation ABC transporters 0 -0.56916996 0 kegg kegg NA NA no no no no up up Antigen processing and presentation Amino sugar and nucleotide sugar metabolism 0 -0.436758893 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Antifolate resistance -0.556521739 -0.632411067 -0.499356499 kegg kegg NA NA no no no no no no Antigen processing and presentation Apoptosis - multiple species 0 -0.583992095 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Axon guidance 0 0.509881423 0 kegg kegg NA NA no no no no up up Antigen processing and presentation Base excision repair 0 -0.462450593 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Biosynthesis of amino acids 0.429565217 0 0.519176319 kegg kegg NA NA no no no no no no Antigen processing and presentation Carbon metabolism 0 0.495059289 0.498326898 kegg kegg NA NA no no no no no no Antigen processing and presentation Cell adhesion molecules 0.509565217 0.538537549 0.705019305 kegg kegg NA NA no no no no no no Antigen processing and presentation Cell cycle 0 -0.429841897 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Cellular senescence 0.619130435 0.420948617 0.496525097 kegg kegg NA NA no no no no no no Antigen processing and presentation Clostridium 0 0.503289904 0 kegg Genus NA 0.925 no no no no no no Antigen processing and presentation Complement and coagulation cascades 0.433913043 0 0.536164736 kegg kegg NA NA no no no no no no Antigen processing and presentation Desulfovibrio 0 0.444554224 0 kegg Genus NA 0.27 no no no no no no Antigen processing and presentation Drug metabolism - cytochrome P450 0.447826087 0 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Endocrine resistance -0.655652174 -0.719367589 -0.459459459 kegg kegg NA NA no no no no no no Antigen processing and presentation Endocytosis 0.619130435 0.537549407 0.577091377 kegg kegg NA NA no no no no no no Antigen processing and presentation ErbB signaling pathway 0 -0.479249012 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Ether lipid metabolism -0.508695652 0 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Fanconi anemia pathway 0 -0.567193676 0 kegg kegg NA NA no no no no no no Antigen processing and presentation FoxO signaling pathway 0 -0.434782609 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Fructose and mannose metabolism 0 -0.589920949 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Glycerolipid metabolism 0 -0.64229249 -0.461261261 kegg kegg NA NA no no no no no up Antigen processing and presentation Glycerophospholipid metabolism -0.733043478 -0.71541502 -0.517631918 kegg kegg NA NA no no no no no up Antigen processing and presentation Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.435652174 -0.603754941 -0.435521236 kegg kegg NA NA no no no no no no Antigen processing and presentation Hedgehog signaling pathway -0.586956522 -0.602766798 -0.523809524 kegg kegg NA NA no no no no no no Antigen processing and presentation Homologous recombination 0 -0.556324111 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Inositol phosphate metabolism -0.5 -0.618577075 -0.592535393 kegg kegg NA NA no no no no no no Antigen processing and presentation Longevity regulating pathway -0.443478261 0 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Lysine degradation 0 -0.643280632 -0.511454311 kegg kegg NA NA no no no no no no Antigen processing and presentation Lysosome 0 0.541501976 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Mannose type O-glycan biosynthesis 0 -0.510869565 -0.421879022 kegg kegg NA NA no no no no no no Antigen processing and presentation MAPK signaling pathway 0 -0.480237154 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Metabolism of xenobiotics by cytochrome P450 0.452173913 0 0 kegg kegg NA NA no no no no no no Antigen processing and presentation mRNA surveillance pathway 0 0 -0.485714286 kegg kegg NA NA no no no no no no Antigen processing and presentation Neuroactive ligand-receptor interaction 0.445217391 0.536561265 0.451222651 kegg kegg NA NA no no no up up up Antigen processing and presentation Notch signaling pathway 0 -0.592885375 -0.406692407 kegg kegg NA NA no no no no no no Antigen processing and presentation Odoribacter 0 0.462606669 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Antigen processing and presentation Oscillospira -0.413043478 0 0 LPS-producing kegg Genus NA 0.62 no no no no no no Antigen processing and presentation Other types of O-glycan biosynthesis -0.479130435 -0.703557312 -0.538223938 kegg kegg NA NA no no no no no no Antigen processing and presentation p53 signaling pathway -0.453043478 -0.567193676 -0.409009009 kegg kegg NA NA no no no no no no Antigen processing and presentation Phagosome 0.50173913 0.533596838 0.658172458 kegg kegg NA NA no no no no no no Antigen processing and presentation Phosphatidylinositol signaling system 0 0 -0.512226512 kegg kegg NA NA no no no no no no Antigen processing and presentation Platinum drug resistance 0 -0.631422925 -0.428571429 kegg kegg NA NA no no no no no no Antigen processing and presentation PPAR signaling pathway 0.52173913 0 0.423938224 kegg kegg NA NA no no no no no no Antigen processing and presentation Proteasome 0 0.496047431 0.47001287 kegg kegg NA NA no no no no no no Antigen processing and presentation Purine metabolism 0 -0.421936759 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Selenocompound metabolism -0.413913043 -0.631422925 -0.41029601 kegg kegg NA NA no no no no no no Antigen processing and presentation Signaling pathways regulating pluripotency of stem cells -0.416521739 -0.520750988 -0.54954955 kegg kegg NA NA no no no no no no Antigen processing and presentation Sphingolipid signaling pathway 0 0.43972332 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Spliceosome 0 -0.509881423 0 kegg kegg NA NA no no no no no no Antigen processing and presentation Taurine and hypotaurine metabolism -0.526086957 -0.690711462 -0.548262548 kegg kegg NA NA no no no no no no Antigen processing and presentation Tight junction 0 0.479249012 0.414929215 kegg kegg NA NA no no no no no no Antigen processing and presentation Viral protein interaction with cytokine and cytokine receptor 0 0 0.454826255 kegg kegg NA NA no no no no no no Apelin signaling pathway 2-Oxocarboxylic acid metabolism 0 0.447628458 0.41003861 kegg kegg NA NA no no no no no no Apelin signaling pathway ABC transporters 0 -0.477272727 0 kegg kegg NA NA no no no no up up Apelin signaling pathway Adrenergic signaling in cardiomyocytes 0 0.669960474 0 kegg kegg NA NA no no no no no up Apelin signaling pathway "Alanine, aspartate and glutamate metabolism" 0 -0.682806324 0 kegg kegg NA NA no no no no no no Apelin signaling pathway alpha-Linolenic acid metabolism 0 -0.754940711 0 kegg kegg NA NA no no no no no no Apelin signaling pathway AMPK signaling pathway 0 0.419960474 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Apoptosis -0.57826087 -0.752964427 -0.62007722 kegg kegg NA NA no no no no no no Apelin signaling pathway Arginine and proline metabolism 0 -0.674901186 0 kegg kegg NA NA no no no no up no Apelin signaling pathway Arginine biosynthesis -0.420869565 -0.62944664 -0.438095238 kegg kegg NA NA no no no no no no Apelin signaling pathway Autophagy - animal 0 -0.68972332 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Autophagy - other 0.570434783 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Bacteroides 0 0.421936759 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Apelin signaling pathway Basal transcription factors 0.603478261 0 0.553925354 kegg kegg NA NA no no no no no no Apelin signaling pathway Base excision repair 0.483478261 0 0.567052767 kegg kegg NA NA no no no no no no Apelin signaling pathway Biosynthesis of amino acids -0.411304348 -0.47826087 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Biosynthesis of cofactors 0 0.48715415 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Butanoate metabolism 0 0.657114625 0.638352638 kegg kegg NA NA no no no no no no Apelin signaling pathway Calcium signaling pathway 0 0.448616601 0 kegg kegg NA NA no no no no up up Apelin signaling pathway Cardiac muscle contraction 0 0.714426877 0 kegg kegg NA NA no no no no no up Apelin signaling pathway Cell cycle 0.592173913 0.482213439 0.419047619 kegg kegg NA NA no no no no no no Apelin signaling pathway Cellular senescence 0 -0.504940711 0 kegg kegg NA NA no no no no no no Apelin signaling pathway cGMP-PKG signaling pathway 0 -0.571146245 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Chemokine signaling pathway 0 -0.460474308 -0.457142857 kegg kegg NA NA no no no no no no Apelin signaling pathway Citrate cycle (TCA cycle) 0 0.647233202 0.615186615 kegg kegg NA NA no no no no no no Apelin signaling pathway Cysteine and methionine metabolism 0.50173913 0.824110672 0.714543115 kegg kegg NA NA no no no no no no Apelin signaling pathway DNA replication 0.509565217 0.612648221 0.686743887 kegg kegg NA NA no no no no no no Apelin signaling pathway Drug metabolism - cytochrome P450 0 0.678853755 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Drug metabolism - other enzymes 0 0.678853755 0 kegg kegg NA NA no no no no no no Apelin signaling pathway EGFR tyrosine kinase inhibitor resistance 0.882608696 0.956521739 0.969369369 kegg kegg NA NA no no no no no no Apelin signaling pathway Endocytosis -0.415652174 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway ErbB signaling pathway 0 -0.428853755 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Fanconi anemia pathway 0.443478261 0 0.512483912 kegg kegg NA NA no no no no no no Apelin signaling pathway Fatty acid biosynthesis 0 -0.707509881 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Fatty acid degradation 0 -0.540513834 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Fatty acid elongation 0 0.428853755 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Fatty acid metabolism 0 -0.498023715 0 kegg kegg NA NA no no no no no no Apelin signaling pathway FoxO signaling pathway 0 -0.638339921 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Fructose and mannose metabolism 0 -0.679841897 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Galactose metabolism 0 -0.725296443 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Glutathione metabolism 0 0.738142292 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Glycerolipid metabolism 0 -0.653162055 0 kegg kegg NA NA no no no no no up Apelin signaling pathway Glycerophospholipid metabolism 0 -0.5 0 kegg kegg NA NA no no no no no up Apelin signaling pathway "Glycine, serine and threonine metabolism" 0 0.416996047 0 kegg kegg NA NA no no no no up no Apelin signaling pathway Glycolysis / Gluconeogenesis 0 0.71541502 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.808300395 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Glycosaminoglycan degradation 0 -0.581027668 0 kegg kegg NA NA no no no no no up Apelin signaling pathway Glycosphingolipid biosynthesis - globo and isoglobo series 0 0 -0.428571429 kegg kegg NA NA no no no no no no Apelin signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0 -0.494071146 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Glyoxylate and dicarboxylate metabolism 0 -0.605731225 0 kegg kegg NA NA no no no no no no Apelin signaling pathway HIF-1 signaling pathway 0.87826087 0.931818182 0.918661519 kegg kegg NA NA no no no no no no Apelin signaling pathway Homologous recombination 0 0 0.462290862 kegg kegg NA NA no no no no no no Apelin signaling pathway Lysine degradation 0.533043478 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Lysosome -0.460869565 0 -0.415186615 kegg kegg NA NA no no no no no no Apelin signaling pathway Metabolism of xenobiotics by cytochrome P450 0 0.622529644 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Mismatch repair 0 0.558300395 0.58970399 kegg kegg NA NA no no no no no no Apelin signaling pathway Mitophagy - animal 0.465217391 0.59486166 0 kegg kegg NA NA no no no no no no Apelin signaling pathway mRNA surveillance pathway 0.51826087 0.567193676 0.474131274 kegg kegg NA NA no no no no no no Apelin signaling pathway mTOR signaling pathway 0.920869565 0.949604743 0.90965251 kegg kegg NA NA no no no no no no Apelin signaling pathway N-Glycan biosynthesis 0.477391304 0.651185771 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Neuroactive ligand-receptor interaction 0 -0.454545455 0 kegg kegg NA NA no no no up up up Apelin signaling pathway NF-kappa B signaling pathway 0 -0.788537549 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Nicotinate and nicotinamide metabolism 0 -0.759881423 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Nitrogen metabolism -0.432173913 -0.552371542 -0.488030888 kegg kegg NA NA no no no no no no Apelin signaling pathway Non-homologous end-joining 0 0.530632411 0.448133848 kegg kegg NA NA no no no no no no Apelin signaling pathway Notch signaling pathway 0 -0.458498024 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Nucleotide excision repair 0.464347826 0.485177866 0.614929215 kegg kegg NA NA no no no no no no Apelin signaling pathway One carbon pool by folate 0 0 0.44967825 kegg kegg NA NA no no no no no no Apelin signaling pathway Oocyte meiosis 0.548695652 0.718379447 0.44967825 kegg kegg NA NA no no no no no no Apelin signaling pathway Other glycan degradation 0 -0.581027668 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Other types of O-glycan biosynthesis 0.440869565 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Oxidative phosphorylation 0 0.736166008 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Pantothenate and CoA biosynthesis 0 -0.75 0 kegg kegg NA NA no no no no no dn Apelin signaling pathway Pentose and glucuronate interconversions 0 0.651185771 0.584041184 kegg kegg NA NA no no no no no no Apelin signaling pathway Pentose phosphate pathway -0.484347826 -0.517786561 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Peroxisome 0 -0.631422925 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Phagosome -0.61826087 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Phenylalanine metabolism 0 0.447628458 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Phospholipase D signaling pathway -0.472173913 -0.816205534 -0.629086229 kegg kegg NA NA no no no no up up Apelin signaling pathway PI3K-Akt signaling pathway 0.613913043 0.503952569 0.887516088 yes kegg kegg NA NA no no no no up up Apelin signaling pathway PPAR signaling pathway 0 -0.533596838 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Propanoate metabolism 0 0.826086957 0.776319176 kegg kegg NA NA no no no no no no Apelin signaling pathway Proteasome 0.435652174 0.583992095 0.548262548 kegg kegg NA NA no no no no no no Apelin signaling pathway Protein export 0.686086957 0.792490119 0.658429858 kegg kegg NA NA no no no no no no Apelin signaling pathway Protein processing in endoplasmic reticulum 0.567826087 0.694664032 0.569111969 kegg kegg NA NA no no no no no no Apelin signaling pathway Pyruvate metabolism 0 0.865612648 0.649163449 kegg kegg NA NA no no no no no no Apelin signaling pathway Rap1 signaling pathway -0.486956522 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Ras signaling pathway 0 0.586956522 0 yes kegg kegg NA NA no no no no up up Apelin signaling pathway Retinol metabolism 0 0 0.408494208 kegg kegg NA NA no no no no no no Apelin signaling pathway Ribosome 0.702608696 0.923913043 0.839382239 kegg kegg NA NA no no no no no no Apelin signaling pathway Ribosome biogenesis in eukaryotes 0.632173913 0 0.574259974 kegg kegg NA NA no no no no no no Apelin signaling pathway RNA degradation 0.54173913 0.707509881 0.572972973 kegg kegg NA NA no no no no no no Apelin signaling pathway RNA polymerase 0.575652174 0.595849802 0.638610039 kegg kegg NA NA no no no no no no Apelin signaling pathway RNA transport 0.526956522 0.906126482 0.726126126 kegg kegg NA NA no no no no no no Apelin signaling pathway Selenocompound metabolism 0.453043478 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway SNARE interactions in vesicular transport 0 -0.685770751 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Spliceosome 0.577391304 0 0.51042471 kegg kegg NA NA no no no no no no Apelin signaling pathway Starch and sucrose metabolism 0 -0.793478261 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Steroid biosynthesis 0.410434783 0 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Synthesis and degradation of ketone bodies 0 0.435770751 0.470785071 kegg kegg NA NA no no no no no no Apelin signaling pathway Taurine and hypotaurine metabolism 0 -0.533596838 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Terpenoid backbone biosynthesis 0.516521739 0 0.465637066 kegg kegg NA NA no no no no no no Apelin signaling pathway TGF-beta signaling pathway 0.406086957 0.782608696 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Thiamine metabolism 0 0.781620553 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Tryptophan metabolism 0 0.429841897 0.490604891 kegg kegg NA NA no no no no up no Apelin signaling pathway Tyrosine metabolism 0 0.558300395 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 0 0.510682111 kegg kegg NA NA no no no no no no Apelin signaling pathway Ubiquitin mediated proteolysis 0.506956522 0.623517787 0 kegg kegg NA NA no no no no no no Apelin signaling pathway "Valine, leucine and isoleucine degradation" 0 0.494071146 0.562934363 kegg kegg NA NA no no no no no no Apelin signaling pathway Various types of N-glycan biosynthesis 0.593913043 0.511857708 0.404118404 kegg kegg NA NA no no no no no no Apelin signaling pathway Vascular smooth muscle contraction 0.445217391 0.608695652 0 kegg kegg NA NA no no no no no no Apelin signaling pathway VEGF signaling pathway 0 -0.450592885 0 kegg kegg NA NA no no no no no no Apelin signaling pathway Wnt signaling pathway 0 0.638339921 0 kegg kegg NA NA no no no no no no Apoptosis 2-Oxocarboxylic acid metabolism 0 -0.518774704 0 kegg kegg NA NA no no no no no no Apoptosis Akkermansia 0 0 0.41151793 acetate-producing kegg Genus NA 0.23 no no no no no no Apoptosis "Alanine, aspartate and glutamate metabolism" 0 0.612648221 0 kegg kegg NA NA no no no no no no Apoptosis alpha-Linolenic acid metabolism 0.58173913 0.434782609 0 kegg kegg NA NA no no no no no no Apoptosis Aminoacyl-tRNA biosynthesis 0 -0.532608696 -0.489317889 kegg kegg NA NA no no no no no no Apoptosis AMPK signaling pathway 0 -0.536561265 0 kegg kegg NA NA no no no no no no Apoptosis Antifolate resistance 0 -0.5256917 0 kegg kegg NA NA no no no no no no Apoptosis Arginine and proline metabolism 0.502608696 0.690711462 0 kegg kegg NA NA no no no no up no Apoptosis Arginine biosynthesis 0 0.619565217 0.5003861 kegg kegg NA NA no no no no no no Apoptosis Autophagy - animal 0 0.633399209 0 kegg kegg NA NA no no no no no no Apoptosis Autophagy - other -0.42 0 -0.474388674 kegg kegg NA NA no no no no no no Apoptosis Basal transcription factors -0.684347826 -0.650197628 -0.748777349 kegg kegg NA NA no no no no no no Apoptosis Base excision repair -0.486956522 -0.652173913 -0.722779923 kegg kegg NA NA no no no no no no Apoptosis Biosynthesis of amino acids 0.6 0.660079051 0.653024453 kegg kegg NA NA no no no no no no Apoptosis Biosynthesis of cofactors 0 -0.871541502 0 kegg kegg NA NA no no no no no no Apoptosis Butanoate metabolism 0 -0.734189723 -0.427541828 kegg kegg NA NA no no no no no no Apoptosis Calcium signaling pathway -0.52173913 0 -0.404375804 kegg kegg NA NA no no no no up up Apoptosis cAMP signaling pathway 0 0.601778656 0 yes kegg kegg NA NA no no no no up up Apoptosis Carbon metabolism 0.45826087 0 0.456885457 kegg kegg NA NA no no no no no no Apoptosis Cell cycle -0.585217391 -0.802371542 -0.645302445 kegg kegg NA NA no no no no no no Apoptosis cGMP-PKG signaling pathway 0 0.764822134 0.404890605 kegg kegg NA NA no no no no no no Apoptosis Chemokine signaling pathway 0 0.681818182 0.636808237 kegg kegg NA NA no no no no no no Apoptosis Citrate cycle (TCA cycle) 0 -0.71541502 -0.475933076 kegg kegg NA NA no no no no no no Apoptosis Cysteine and methionine metabolism 0 -0.787549407 -0.61981982 kegg kegg NA NA no no no no no no Apoptosis DNA replication -0.48173913 -0.826086957 -0.681338481 kegg kegg NA NA no no no no no no Apoptosis Drug metabolism - cytochrome P450 0 -0.744071146 0 kegg kegg NA NA no no no no no no Apoptosis Drug metabolism - other enzymes 0 -0.609683794 0 kegg kegg NA NA no no no no no no Apoptosis EGFR tyrosine kinase inhibitor resistance -0.477391304 -0.648221344 -0.605405405 kegg kegg NA NA no no no no no no Apoptosis Endocrine resistance -0.442608696 0 0 kegg kegg NA NA no no no no no no Apoptosis Endocytosis 0.506956522 0.718379447 0 kegg kegg NA NA no no no no no no Apoptosis Ether lipid metabolism 0 -0.578063241 -0.421879022 kegg kegg NA NA no no no no no no Apoptosis Fanconi anemia pathway 0 -0.588932806 -0.657657658 kegg kegg NA NA no no no no no no Apoptosis Fatty acid biosynthesis 0 0.666996047 0 kegg kegg NA NA no no no no no no Apoptosis Fructose and mannose metabolism 0.539130435 0 0 kegg kegg NA NA no no no no no no Apoptosis Galactose metabolism 0.642608696 0.522727273 0 kegg kegg NA NA no no no no no no Apoptosis Glutathione metabolism 0 -0.753952569 0 kegg kegg NA NA no no no no no no Apoptosis "Glycine, serine and threonine metabolism" 0 -0.756916996 0 kegg kegg NA NA no no no no up no Apoptosis Glycolysis / Gluconeogenesis 0 -0.468379447 0 kegg kegg NA NA no no no no no no Apoptosis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.543478261 0.672924901 0 kegg kegg NA NA no no no no no no Apoptosis Glycosaminoglycan biosynthesis - keratan sulfate -0.410434783 0 0 kegg kegg NA NA no no no no no no Apoptosis Glycosaminoglycan degradation 0.533913043 0.68972332 0 kegg kegg NA NA no no no no no up Apoptosis Glycosphingolipid biosynthesis - ganglio series 0 -0.424901186 0 kegg kegg NA NA no no no no no no Apoptosis Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.490118577 0 kegg kegg NA NA no no no no no no Apoptosis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.506916996 0 kegg kegg NA NA no no no no no no Apoptosis Glyoxylate and dicarboxylate metabolism 0 0.645256917 0.478507079 kegg kegg NA NA no no no no no no Apoptosis HIF-1 signaling pathway -0.485217391 -0.570158103 -0.453024453 kegg kegg NA NA no no no no no no Apoptosis Homologous recombination 0 0 -0.631402831 kegg kegg NA NA no no no no no no Apoptosis Lysine degradation 0 0 -0.555212355 kegg kegg NA NA no no no no no no Apoptosis Lysosome 0.573043478 0.684782609 0.701415701 kegg kegg NA NA no no no no no no Apoptosis Mannose type O-glycan biosynthesis 0 0 -0.469498069 kegg kegg NA NA no no no no no no Apoptosis Metabolism of xenobiotics by cytochrome P450 0 -0.647233202 0 kegg kegg NA NA no no no no no no Apoptosis Mismatch repair 0 -0.809288538 -0.505791506 kegg kegg NA NA no no no no no no Apoptosis Mitophagy - animal 0 -0.48715415 0 kegg kegg NA NA no no no no no no Apoptosis mRNA surveillance pathway -0.599130435 -0.579051383 -0.668983269 kegg kegg NA NA no no no no no no Apoptosis mTOR signaling pathway -0.495652174 -0.654150198 -0.571428571 kegg kegg NA NA no no no no no no Apoptosis N-Glycan biosynthesis -0.646086957 -0.746047431 -0.591505792 kegg kegg NA NA no no no no no no Apoptosis Neuroactive ligand-receptor interaction 0.463478261 0.562252964 0.62985843 kegg kegg NA NA no no no up up up Apoptosis NF-kappa B signaling pathway 0 0.718379447 0 kegg kegg NA NA no no no no no no Apoptosis Nicotinate and nicotinamide metabolism 0 0.753952569 0.503989704 kegg kegg NA NA no no no no no no Apoptosis Nitrogen metabolism 0.508695652 0.556324111 0.416216216 kegg kegg NA NA no no no no no no Apoptosis Non-homologous end-joining 0 -0.506916996 0 kegg kegg NA NA no no no no no no Apoptosis Nucleotide excision repair -0.486086957 -0.831027668 -0.665122265 kegg kegg NA NA no no no no no no Apoptosis One carbon pool by folate -0.428695652 -0.799407115 -0.564993565 kegg kegg NA NA no no no no no no Apoptosis Oocyte meiosis -0.648695652 -0.650197628 -0.550836551 kegg kegg NA NA no no no no no no Apoptosis Other glycan degradation 0.432173913 0 0 kegg kegg NA NA no no no no no no Apoptosis Other types of O-glycan biosynthesis -0.522608696 0 -0.576833977 kegg kegg NA NA no no no no no no Apoptosis Oxidative phosphorylation -0.432173913 -0.556324111 0 kegg kegg NA NA no no no no no no Apoptosis p53 signaling pathway -0.519130435 0 -0.527927928 kegg kegg NA NA no no no no no no Apoptosis Pantothenate and CoA biosynthesis 0 0.640316206 0 kegg kegg NA NA no no no no no dn Apoptosis Parabacteroides 0 0 0.404916662 kegg Genus NA 4.19E-05 no no no no up up Apoptosis Pentose and glucuronate interconversions 0 -0.717391304 0 kegg kegg NA NA no no no no no no Apoptosis Pentose phosphate pathway 0.8 0.700592885 0.612355212 kegg kegg NA NA no no no no no no Apoptosis Peroxisome 0 0.483201581 0 kegg kegg NA NA no no no no no no Apoptosis Phagosome 0.619130435 0.70256917 0.64967825 kegg kegg NA NA no no no no no no Apoptosis Phenylalanine metabolism 0 -0.539525692 0 kegg kegg NA NA no no no no no no Apoptosis Phosphatidylinositol signaling system -0.602608696 -0.488142292 -0.536422136 kegg kegg NA NA no no no no no no Apoptosis Phospholipase D signaling pathway 0 0.705533597 0 kegg kegg NA NA no no no no up up Apoptosis PI3K-Akt signaling pathway 0 0 -0.594079794 yes kegg kegg NA NA no no no no up up Apoptosis Platinum drug resistance -0.469565217 0 -0.404890605 kegg kegg NA NA no no no no no no Apoptosis Porphyrin and chlorophyll metabolism 0 -0.691699605 0 kegg kegg NA NA no no no no no no Apoptosis PPAR signaling pathway 0 0.753952569 0.489317889 kegg kegg NA NA no no no no no no Apoptosis Primary bile acid biosynthesis 0 -0.419960474 0 kegg kegg NA NA no no no no no no Apoptosis Propanoate metabolism 0 -0.76284585 -0.586357786 kegg kegg NA NA no no no no no no Apoptosis Proteasome 0 -0.503952569 0 kegg kegg NA NA no no no no no no Apoptosis Protein export -0.777391304 -0.619565217 -0.586100386 kegg kegg NA NA no no no no no no Apoptosis Protein processing in endoplasmic reticulum -0.553043478 -0.767786561 -0.575804376 kegg kegg NA NA no no no no no no Apoptosis Purine metabolism 0 -0.679841897 0 kegg kegg NA NA no no no no no no Apoptosis Pyrimidine metabolism 0 -0.720355731 0 kegg kegg NA NA no no no no no no Apoptosis Pyruvate metabolism 0 -0.855731225 -0.563191763 kegg kegg NA NA no no no no no no Apoptosis Rap1 signaling pathway 0.556521739 0 0.579407979 kegg kegg NA NA no no no no no no Apoptosis Ras signaling pathway 0 -0.600790514 -0.45997426 yes kegg kegg NA NA no no no no up up Apoptosis Retinol metabolism 0 -0.630434783 0 kegg kegg NA NA no no no no no no Apoptosis Ribosome -0.646086957 -0.628458498 -0.443758044 kegg kegg NA NA no no no no no no Apoptosis Ribosome biogenesis in eukaryotes -0.674782609 -0.727272727 -0.738223938 kegg kegg NA NA no no no no no no Apoptosis RNA degradation -0.603478261 -0.663043478 -0.623166023 kegg kegg NA NA no no no no no no Apoptosis RNA polymerase -0.807826087 -0.800395257 -0.663320463 kegg kegg NA NA no no no no no no Apoptosis RNA transport 0 -0.555335968 -0.520978121 kegg kegg NA NA no no no no no no Apoptosis Sarcina 0 0.444554224 0 kegg Genus NA 0.0703 no no no no no no Apoptosis Selenocompound metabolism -0.452173913 0 -0.517117117 kegg kegg NA NA no no no no no no Apoptosis SNARE interactions in vesicular transport 0 0.454545455 0 kegg kegg NA NA no no no no no no Apoptosis Sphingolipid metabolism 0.57826087 0 0 kegg kegg NA NA no no no no no no Apoptosis Sphingolipid signaling pathway 0 0.67687747 0 kegg kegg NA NA no no no no no no Apoptosis Spliceosome -0.486956522 0 -0.692406692 kegg kegg NA NA no no no no no no Apoptosis Starch and sucrose metabolism 0.696521739 0.659090909 0.477734878 kegg kegg NA NA no no no no no no Apoptosis Steroid biosynthesis -0.725217391 -0.649209486 -0.402831403 kegg kegg NA NA no no no no no no Apoptosis Steroid hormone biosynthesis 0 -0.580039526 0 kegg kegg NA NA no no no no no no Apoptosis Sulfur metabolism 0 -0.559288538 0 kegg kegg NA NA no no no no no no Apoptosis Synthesis and degradation of ketone bodies 0 -0.817193676 -0.58043758 kegg kegg NA NA no no no no no no Apoptosis Terpenoid backbone biosynthesis -0.58173913 -0.46541502 -0.522522523 kegg kegg NA NA no no no no no no Apoptosis Thiamine metabolism 0 -0.767786561 0 kegg kegg NA NA no no no no no no Apoptosis Tryptophan metabolism 0 -0.499011858 0 kegg kegg NA NA no no no no up no Apoptosis Tyrosine metabolism 0 -0.76284585 0 kegg kegg NA NA no no no no no no Apoptosis Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.677865613 -0.603346203 kegg kegg NA NA no no no no no no Apoptosis Ubiquitin mediated proteolysis -0.432173913 -0.602766798 0 kegg kegg NA NA no no no no no no Apoptosis "Valine, leucine and isoleucine degradation" 0 -0.695652174 0 kegg kegg NA NA no no no no no no Apoptosis Various types of N-glycan biosynthesis -0.509565217 -0.627470356 -0.517117117 kegg kegg NA NA no no no no no no Apoptosis - multiple species ABC transporters 0 0.861660079 0 kegg kegg NA NA no no no no up up Apoptosis - multiple species Amino sugar and nucleotide sugar metabolism 0 0.595849802 0.417503218 kegg kegg NA NA no no no no no no Apoptosis - multiple species Aminoacyl-tRNA biosynthesis 0.430434783 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Antifolate resistance 0 0.435770751 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Apoptosis -0.506956522 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Autophagy - animal 0.477391304 0.47826087 0.437323037 kegg kegg NA NA no no no no no no Apoptosis - multiple species Autophagy - other 0.476521739 0.710474308 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Basal transcription factors 0.665217391 0.585968379 0.494208494 kegg kegg NA NA no no no no no no Apoptosis - multiple species Base excision repair 0.824347826 0.639328063 0.516087516 kegg kegg NA NA no no no no no no Apoptosis - multiple species Carbon metabolism 0 -0.492094862 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Cell cycle 0.502608696 0.463438735 0.442985843 kegg kegg NA NA no no no no no no Apoptosis - multiple species Chemokine signaling pathway -0.428695652 0 -0.583011583 kegg kegg NA NA no no no no no no Apoptosis - multiple species DNA replication 0.539130435 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Endocytosis 0 0 -0.642471042 kegg kegg NA NA no no no no no no Apoptosis - multiple species ErbB signaling pathway 0.429565217 0.461462451 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Fanconi anemia pathway 0.605217391 0.675889328 0.546718147 kegg kegg NA NA no no no no no no Apoptosis - multiple species Fatty acid degradation 0 0.443675889 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species FoxO signaling pathway 0.47826087 0.7756917 0.697554698 kegg kegg NA NA no no no no no no Apoptosis - multiple species Fructose and mannose metabolism 0 0.472332016 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Glycerolipid metabolism 0 0.799407115 0 kegg kegg NA NA no no no no no up Apoptosis - multiple species Glycerophospholipid metabolism 0.536521739 0.816205534 0.424195624 kegg kegg NA NA no no no no no up Apoptosis - multiple species Glycolysis / Gluconeogenesis 0 -0.510869565 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.457509881 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Glycosaminoglycan degradation -0.717391304 0 0 kegg kegg NA NA no no no no no up Apoptosis - multiple species Glycosphingolipid biosynthesis - ganglio series 0 0.433794466 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Glycosphingolipid biosynthesis - globo and isoglobo series -0.577391304 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.499130435 0.583992095 0.427284427 kegg kegg NA NA no no no no no no Apoptosis - multiple species HIF-1 signaling pathway 0 -0.466403162 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Homologous recombination 0.597391304 0.760869565 0.654826255 kegg kegg NA NA no no no no no no Apoptosis - multiple species Inositol phosphate metabolism 0 0.873517787 0.581209781 kegg kegg NA NA no no no no no no Apoptosis - multiple species Linoleic acid metabolism -0.525217391 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Longevity regulating pathway 0 0.489130435 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Lysine degradation 0.414782609 0.693675889 0.410553411 kegg kegg NA NA no no no no no no Apoptosis - multiple species Lysosome -0.524347826 -0.485177866 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Mannose type O-glycan biosynthesis 0 0.539525692 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species MAPK signaling pathway 0 0.692687747 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Mucin type O-glycan biosynthesis 0 0.606719368 0.442213642 kegg kegg NA NA no no no no no no Apoptosis - multiple species N-Glycan biosynthesis 0.550434783 0 0.43989704 kegg kegg NA NA no no no no no no Apoptosis - multiple species Neuroactive ligand-receptor interaction -0.432173913 0 0 kegg kegg NA NA no no no up up up Apoptosis - multiple species NF-kappa B signaling pathway 0.406956522 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Nucleotide excision repair 0.566956522 0 0.512226512 kegg kegg NA NA no no no no no no Apoptosis - multiple species One carbon pool by folate 0.485217391 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Other glycan degradation 0 0.628458498 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Other types of O-glycan biosynthesis 0.466086957 0.756916996 0.597425997 kegg kegg NA NA no no no no no no Apoptosis - multiple species Oxidative phosphorylation 0 -0.4743083 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species p53 signaling pathway 0.844347826 0.872529644 0.792020592 kegg kegg NA NA no no no no no no Apoptosis - multiple species Pentose phosphate pathway -0.522608696 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Phagosome 0 -0.421936759 -0.619305019 kegg kegg NA NA no no no no no no Apoptosis - multiple species Phosphatidylinositol signaling system 0.405217391 0.609683794 0.469240669 kegg kegg NA NA no no no no no no Apoptosis - multiple species Platinum drug resistance 0.950434783 0.95256917 0.928700129 kegg kegg NA NA no no no no no no Apoptosis - multiple species PPAR signaling pathway 0 0 -0.523037323 kegg kegg NA NA no no no no no no Apoptosis - multiple species Rap1 signaling pathway -0.810434783 -0.683794466 -0.455341055 kegg kegg NA NA no no no no no no Apoptosis - multiple species Retinol metabolism 0 0 0.436550837 kegg kegg NA NA no no no no no no Apoptosis - multiple species Ribosome 0 -0.518774704 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Ribosome biogenesis in eukaryotes 0.725217391 0.484189723 0.421621622 kegg kegg NA NA no no no no no no Apoptosis - multiple species RNA polymerase 0.674782609 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Selenocompound metabolism 0.737391304 0.808300395 0.654311454 kegg kegg NA NA no no no no no no Apoptosis - multiple species SNARE interactions in vesicular transport 0 0.619565217 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Sphingolipid metabolism -0.551304348 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Spliceosome 0.715652174 0.829051383 0.499099099 kegg kegg NA NA no no no no no no Apoptosis - multiple species Steroid biosynthesis 0 0 0.413127413 kegg kegg NA NA no no no no no no Apoptosis - multiple species Taurine and hypotaurine metabolism 0.613913043 0.651185771 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Terpenoid backbone biosynthesis 0.446956522 0.52173913 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Various types of N-glycan biosynthesis 0.494782609 0 0 kegg kegg NA NA no no no no no no Apoptosis - multiple species Viral protein interaction with cytokine and cytokine receptor 0 0 -0.401029601 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Amino sugar and nucleotide sugar metabolism 0.411304348 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism beta-Alanine metabolism 0.413043478 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Collinsella 0 0 0.448610227 kegg Genus NA 0.128 no no no no no no Arachidonic acid metabolism Glutathione metabolism 0.856521739 0.456521739 0.855855856 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Glycerolipid metabolism 0 0 -0.461261261 kegg kegg NA NA no no no no no up Arachidonic acid metabolism Glycerophospholipid metabolism 0 0 -0.480823681 kegg kegg NA NA no no no no no up Arachidonic acid metabolism "Glycine, serine and threonine metabolism" 0.455652174 0 0.676705277 kegg kegg NA NA no no no no up no Arachidonic acid metabolism Inositol phosphate metabolism 0 0 -0.444015444 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Lysine degradation 0 0 -0.531016731 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Mannose type O-glycan biosynthesis 0 -0.463438735 -0.477734878 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Mucin type O-glycan biosynthesis 0 -0.482213439 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism N-Glycan biosynthesis 0 0 -0.578378378 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Other types of O-glycan biosynthesis 0 0 -0.4998713 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Paraprevotella 0 0 0.425415742 kegg Genus NA 0.118 no no no no no no Arachidonic acid metabolism Phenylalanine metabolism 0.405217391 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Purine metabolism 0.532173913 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Pyrimidine metabolism 0.545217391 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Taurine and hypotaurine metabolism 0 0 -0.410810811 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Tryptophan metabolism 0.430434783 0 0 kegg kegg NA NA no no no no up no Arachidonic acid metabolism Tyrosine metabolism 0.533043478 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.454782609 0 0 kegg kegg NA NA no no no no no no Arachidonic acid metabolism Various types of N-glycan biosynthesis 0 0 -0.67001287 kegg kegg NA NA no no no no no no Arginine and proline metabolism "Alanine, aspartate and glutamate metabolism" 0.745217391 0.873517787 0.552380952 kegg kegg NA NA no up no no no no Arginine and proline metabolism Arginine biosynthesis 0.786956522 0.85770751 0.58996139 kegg kegg NA NA no up no no no no Arginine and proline metabolism Blautia 0.422608696 0 0 acetate-producing kegg Genus NA 1.36E-05 no up no up dn dn Arginine and proline metabolism Citrate cycle (TCA cycle) 0 -0.634387352 0 kegg kegg NA NA no up no no no no Arginine and proline metabolism Cysteine and methionine metabolism 0 -0.640316206 -0.53951094 kegg kegg NA NA no up no no no no Arginine and proline metabolism Fatty acid biosynthesis 0.793913043 0.840909091 0.633719434 kegg kegg NA NA no up no no no no Arginine and proline metabolism Fatty acid degradation 0.647826087 0.639328063 0 kegg kegg NA NA no up no no no no Arginine and proline metabolism Galactose metabolism 0.415652174 0.469367589 0 kegg kegg NA NA no up no no no no Arginine and proline metabolism "Glycine, serine and threonine metabolism" -0.454782609 0 0 kegg kegg NA NA no up no no up no Arginine and proline metabolism Glycolysis / Gluconeogenesis 0 -0.5256917 0 kegg kegg NA NA no up no no no no Arginine and proline metabolism Odoribacter 0.474395625 0 0 butyrate-producing kegg Genus NA 0.798 no up no no no no Arginine and proline metabolism Oxidative phosphorylation 0 -0.776679842 -0.574002574 kegg kegg NA NA no up no no no no Arginine and proline metabolism Paraprevotella 0 -0.470822224 0 kegg Genus NA 0.118 no up no no no no Arginine and proline metabolism Pentose and glucuronate interconversions 0 -0.745059289 -0.454311454 kegg kegg NA NA no up no no no no Arginine and proline metabolism Pentose phosphate pathway 0.427826087 0.652173913 0.613384813 kegg kegg NA NA no up no no no no Arginine and proline metabolism Purine metabolism 0 -0.451581028 0 kegg kegg NA NA no up no no no no Arginine and proline metabolism Pyrimidine metabolism 0 -0.62055336 0 kegg kegg NA NA no up no no no no Arginine and proline metabolism Slackia 0 0 -0.420317831 kegg Genus NA 0.94 no up no no no no Arginine and proline metabolism Steroid biosynthesis -0.422608696 -0.464426877 -0.588159588 kegg kegg NA NA no up no no no no Arginine and proline metabolism Synthesis and degradation of ketone bodies 0 -0.542490119 0 kegg kegg NA NA no up no no no no Arginine and proline metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.457509881 0 kegg kegg NA NA no up no no no no Arginine and proline metabolism "Valine, leucine and isoleucine degradation" 0 -0.56916996 0 kegg kegg NA NA no up no no no no Arginine biosynthesis Ascorbate and aldarate metabolism 0 -0.527667984 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Citrate cycle (TCA cycle) 0 -0.671936759 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Fatty acid biosynthesis 0.907826087 0.93972332 0.738481338 kegg kegg NA NA no no no no no no Arginine biosynthesis Fatty acid degradation 0.726086957 0.747035573 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Galactose metabolism 0.415652174 0.523715415 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Glycolysis / Gluconeogenesis 0 -0.469367589 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Oxidative phosphorylation -0.547826087 -0.71541502 -0.466666667 kegg kegg NA NA no no no no no no Arginine biosynthesis Pentose and glucuronate interconversions 0 -0.840909091 -0.631660232 kegg kegg NA NA no no no no no no Arginine biosynthesis Pentose phosphate pathway 0.519130435 0.637351779 0.762162162 kegg kegg NA NA no no no no no no Arginine biosynthesis Steroid biosynthesis -0.444347826 0 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Steroid hormone biosynthesis 0 -0.418972332 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Synthesis and degradation of ketone bodies 0 -0.431818182 0 kegg kegg NA NA no no no no no no Arginine biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.489130435 0 kegg kegg NA NA no no no no no no Arrhythmogenic right ventricular cardiomyopathy 2-Oxocarboxylic acid metabolism 0.415652174 0.571146245 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy ABC transporters 0 -0.455533597 0 kegg kegg NA NA no up up no up up Arrhythmogenic right ventricular cardiomyopathy Acute myeloid leukemia 0 -0.438735178 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Adherens junction 0.92 0.945652174 0.964221364 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Adipocytokine signaling pathway 0 -0.612648221 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Adrenergic signaling in cardiomyocytes 0 0.433794466 0 kegg kegg NA NA no up up no no up Arrhythmogenic right ventricular cardiomyopathy AGE-RAGE signaling pathway in diabetic complications 0 -0.625494071 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy "Alanine, aspartate and glutamate metabolism" 0 -0.718379447 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Allograft rejection 0.406956522 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy alpha-Linolenic acid metabolism 0 -0.41798419 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Alzheimer disease 0 0.605731225 0.459202059 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Amoebiasis 0 -0.416007905 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Amphetamine addiction 0 0.442687747 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Amyotrophic lateral sclerosis 0 0.644268775 0.616216216 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Apelin signaling pathway -0.452173913 0.46541502 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Apoptosis 0.530434783 0 0.412355212 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Apoptosis - multiple species -0.604347826 -0.486166008 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Arginine and proline metabolism 0 -0.646245059 -0.405148005 kegg kegg NA NA no up up no up no Arrhythmogenic right ventricular cardiomyopathy Arginine biosynthesis 0 -0.663043478 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Ascorbate and aldarate metabolism 0 0.479249012 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Asthma 0 0.489130435 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Autoimmune thyroid disease 0.406956522 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Autophagy - animal -0.728695652 -0.893280632 -0.53951094 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Autophagy - other -0.876521739 -0.740118577 -0.511454311 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy B cell receptor signaling pathway 0 -0.583003953 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Bacterial invasion of epithelial cells 0.905217391 0.861660079 0.919176319 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Basal transcription factors -0.72173913 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Base excision repair -0.544347826 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy beta-Alanine metabolism 0.435652174 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Bifidobacterium 0 0.464587854 0 acetate-producing kegg Genus NA 0.105 no up up no dn no Arrhythmogenic right ventricular cardiomyopathy Bile secretion 0 0.440711462 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Biosynthesis of cofactors 0.427826087 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Bladder cancer 0 -0.610671937 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Breast cancer 0 -0.691699605 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Butanoate metabolism 0 0.541501976 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy C-type lectin receptor signaling pathway -0.505217391 -0.683794466 -0.549034749 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Calcium signaling pathway 0 0.45256917 0 kegg kegg NA NA no up up no up up Arrhythmogenic right ventricular cardiomyopathy Carbohydrate digestion and absorption -0.487826087 -0.458498024 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Carbon metabolism 0.430434783 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Cardiac muscle contraction 0 0.636363636 0.56036036 kegg kegg NA NA no up up no no up Arrhythmogenic right ventricular cardiomyopathy Cell adhesion molecules 0.427826087 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Cell cycle -0.410434783 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Chagas disease 0 -0.606719368 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Choline metabolism in cancer -0.466086957 -0.528656126 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Cholinergic synapse -0.459130435 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Chronic myeloid leukemia 0 -0.553359684 -0.535135135 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Circadian entrainment 0 0.666996047 0 kegg kegg NA NA no up up no up up Arrhythmogenic right ventricular cardiomyopathy Circadian rhythm -0.65826087 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Citrate cycle (TCA cycle) 0 0.536561265 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Coronavirus disease - COVID-19 0 0.466403162 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Cysteine and methionine metabolism 0 0.434782609 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Cytokine-cytokine receptor interaction 0 0 0.651480051 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Cytosolic DNA-sensing pathway 0 -0.455533597 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy DNA replication 0 0.480237154 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Dopaminergic synapse 0 0.552371542 0 kegg kegg NA NA no up up no up no Arrhythmogenic right ventricular cardiomyopathy Drug metabolism - cytochrome P450 0 0.694664032 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Drug metabolism - other enzymes 0 0.753952569 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy EGFR tyrosine kinase inhibitor resistance -0.416521739 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Endocrine and other factor-regulated calcium reabsorption 0 0.530632411 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Endometrial cancer 0 -0.611660079 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Epithelial cell signaling in Helicobacter pylori infection 0 -0.494071146 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy ErbB signaling pathway 0 -0.51284585 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Estrogen signaling pathway 0 0.502964427 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Fatty acid biosynthesis 0 -0.634387352 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Fatty acid degradation 0 -0.566205534 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Fatty acid metabolism 0 -0.522727273 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Fc epsilon RI signaling pathway 0 -0.552371542 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Focal adhesion 0.891304348 0.927865613 0.907335907 kegg kegg NA NA no up up no up up Arrhythmogenic right ventricular cardiomyopathy Folate biosynthesis 0 0.447628458 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy FoxO signaling pathway -0.417391304 -0.694664032 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy GABAergic synapse -0.419130435 -0.556324111 0 kegg kegg NA NA no up up no up up Arrhythmogenic right ventricular cardiomyopathy Galactose metabolism 0.455652174 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Gap junction 0.44 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Gastric acid secretion 0.883478261 0.946640316 0.906048906 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Glioma -0.495652174 -0.433794466 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Glucagon signaling pathway 0 0.441699605 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Glutathione metabolism 0 0.484189723 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Glycerolipid metabolism 0 -0.485177866 0 kegg kegg NA NA no up up no no up Arrhythmogenic right ventricular cardiomyopathy Glycerophospholipid metabolism -0.429565217 -0.519762846 0 kegg kegg NA NA no up up no no up Arrhythmogenic right ventricular cardiomyopathy Glycolysis / Gluconeogenesis 0 0.575098814 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.635375494 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.574782609 0.445652174 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Glyoxylate and dicarboxylate metabolism 0 -0.675889328 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy GnRH secretion 0 -0.511857708 0 kegg kegg NA NA no up up no up up Arrhythmogenic right ventricular cardiomyopathy Hematopoietic cell lineage 0 0 0.506048906 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Hepatitis B -0.593043478 -0.852766798 -0.488288288 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Hepatitis C 0 -0.576086957 -0.43011583 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Hepatocellular carcinoma 0.894782609 0.941699605 0.918661519 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy HIF-1 signaling pathway -0.506956522 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Hippo signaling pathway 0.863478261 0.929841897 0.937966538 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Hippo signaling pathway - multiple species 0 -0.581027668 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Huntington disease 0 0.615612648 0.537966538 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Hypertrophic cardiomyopathy 0.982608696 0.985177866 0.992277992 kegg kegg NA NA no up up no up up Arrhythmogenic right ventricular cardiomyopathy Inflammatory mediator regulation of TRP channels 0 0.574110672 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Influenza A 0.53826087 0 0.672844273 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Inositol phosphate metabolism 0 -0.453557312 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Insulin resistance -0.647826087 -0.707509881 -0.606949807 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Insulin signaling pathway -0.50173913 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy JAK-STAT signaling pathway 0 -0.703557312 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Lachnospira 0 0.559426753 0 butyrate-producing kegg Genus NA 0.279 no up up no no no Arrhythmogenic right ventricular cardiomyopathy Leukocyte transendothelial migration 0.74173913 0.568181818 0.692664093 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Long-term potentiation -0.544347826 0 0 kegg kegg NA NA no up up no no up Arrhythmogenic right ventricular cardiomyopathy Longevity regulating pathway 0 -0.445652174 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Lysine degradation -0.406086957 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Malaria 0 -0.419960474 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy MAPK signaling pathway 0 -0.532608696 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Melanogenesis 0 0.552371542 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Melanoma -0.536521739 -0.711462451 -0.431660232 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Metabolism of xenobiotics by cytochrome P450 0 0.710474308 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy MicroRNAs in cancer 0 -0.779644269 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Morphine addiction 0 0.508893281 0 kegg kegg NA NA no up up no up up Arrhythmogenic right ventricular cardiomyopathy mRNA surveillance pathway -0.522608696 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Mucin type O-glycan biosynthesis 0 -0.563241107 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy N-Glycan biosynthesis 0 0.574110672 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Neurotrophin signaling pathway 0 -0.578063241 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy NF-kappa B signaling pathway 0 -0.767786561 -0.643243243 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Nicotinate and nicotinamide metabolism 0 -0.587944664 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Nitrogen metabolism 0 -0.68083004 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy NOD-like receptor signaling pathway 0 -0.760869565 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Non-alcoholic fatty liver disease 0 0.517786561 0.502187902 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Non-small cell lung cancer 0 -0.475296443 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy One carbon pool by folate 0 0.482213439 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Oocyte meiosis -0.43826087 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Osteoclast differentiation 0 -0.583992095 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Other types of O-glycan biosynthesis -0.48173913 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Ovarian steroidogenesis 0.446086957 0 0 kegg kegg NA NA no up up no up up Arrhythmogenic right ventricular cardiomyopathy Oxidative phosphorylation 0 0.621541502 0.558301158 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Oxytocin signaling pathway 0.882608696 0.719367589 0.648133848 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy p53 signaling pathway -0.720869565 -0.53458498 -0.427284427 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Pancreatic secretion 0 0.609683794 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Pantothenate and CoA biosynthesis 0 -0.570158103 0 kegg kegg NA NA no up up no no dn Arrhythmogenic right ventricular cardiomyopathy Paraprevotella 0 0.417444123 0 kegg Genus NA 0.118 no up up no no no Arrhythmogenic right ventricular cardiomyopathy Parkinson disease 0 0.51284585 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Pathogenic Escherichia coli infection 0.48173913 0 0.595366795 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Pathways in cancer -0.530434783 -0.557312253 -0.433719434 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Pathways of neurodegeneration - multiple diseases 0 0.479249012 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy PD-L1 expression and PD-1 checkpoint pathway in cancer -0.499130435 -0.808300395 -0.54028314 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Pentose and glucuronate interconversions 0 0.54743083 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Pentose phosphate pathway 0.430434783 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Peroxisome 0 -0.626482213 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Phagosome 0.511304348 0 0.401801802 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Phenylalanine metabolism 0.70173913 0.731225296 0.615444015 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Phosphatidylinositol signaling system -0.49826087 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Phospholipase D signaling pathway 0 -0.46541502 0 kegg kegg NA NA no up up no up up Arrhythmogenic right ventricular cardiomyopathy Phototransduction 0 0.523715415 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Platelet activation 0.924347826 0.912055336 0.854568855 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Platinum drug resistance -0.651304348 -0.429841897 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy PPAR signaling pathway 0 -0.625494071 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Prion disease 0 0.631422925 0.622908623 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Progesterone-mediated oocyte maturation -0.596521739 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Prolactin signaling pathway 0 -0.52173913 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Prostate cancer -0.474782609 -0.625494071 -0.530759331 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Proteasome -0.600869565 0.505928854 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Protein digestion and absorption 0 -0.536561265 0 yes kegg kegg NA NA no up up no up up Arrhythmogenic right ventricular cardiomyopathy Protein export -0.603478261 0.528656126 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Protein processing in endoplasmic reticulum 0 0.45256917 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Proteoglycans in cancer 0 0.539525692 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Proximal tubule bicarbonate reclamation 0 0.542490119 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Pyrimidine metabolism 0 0.540513834 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Pyruvate metabolism 0 0.456521739 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Rap1 signaling pathway 0.864347826 0.820158103 0.814671815 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Ras signaling pathway 0 0.590909091 0 yes kegg kegg NA NA no up up no up up Arrhythmogenic right ventricular cardiomyopathy Regulation of actin cytoskeleton 0.614782609 0.598814229 0.664092664 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Renal cell carcinoma 0 0 -0.502187902 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Renin secretion 0 0.661067194 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Retrograde endocannabinoid signaling 0 0.649209486 0.425997426 kegg kegg NA NA no up up no no up Arrhythmogenic right ventricular cardiomyopathy Rheumatoid arthritis 0 0 0.417245817 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Ribosome 0 0.4743083 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Ribosome biogenesis in eukaryotes -0.503478261 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy RIG-I-like receptor signaling pathway -0.555652174 -0.801383399 -0.609009009 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy RNA degradation -0.519130435 0.442687747 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy RNA polymerase -0.640869565 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Salivary secretion 0 0.568181818 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Salmonella infection 0 0 0.620592021 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Selenocompound metabolism -0.604347826 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Small cell lung cancer -0.434782609 -0.688735178 -0.607464607 kegg kegg NA NA no up up no no up Arrhythmogenic right ventricular cardiomyopathy SNARE interactions in vesicular transport 0 -0.648221344 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Spinocerebellar ataxia -0.846086957 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Spliceosome -0.66173913 -0.463438735 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Starch and sucrose metabolism 0 -0.563241107 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Steroid hormone biosynthesis 0 0.459486166 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Sulfur metabolism 0.428695652 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy T cell receptor signaling pathway 0 -0.717391304 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Taurine and hypotaurine metabolism 0 -0.550395257 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Terpenoid backbone biosynthesis -0.497391304 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy TGF-beta signaling pathway 0 0.472332016 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Thermogenesis 0 0.643280632 0.522007722 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Thiamine metabolism 0 0 -0.484169884 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Thyroid hormone signaling pathway 0.836521739 0.928853755 0.864092664 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Tight junction 0.795652174 0.839920949 0.683912484 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy TNF signaling pathway 0 -0.659090909 -0.407464607 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Toll-like receptor signaling pathway 0 -0.638339921 0 yes kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Transcriptional misregulation in cancer -0.793913043 -0.868577075 -0.68983269 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Tryptophan metabolism 0 0.447628458 0 kegg kegg NA NA no up up no up no Arrhythmogenic right ventricular cardiomyopathy Type I diabetes mellitus 0.406956522 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Type II diabetes mellitus -0.440869565 -0.690711462 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Tyrosine metabolism 0 0.593873518 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy "Valine, leucine and isoleucine degradation" 0 0.5 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Various types of N-glycan biosynthesis -0.437391304 0 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Vascular smooth muscle contraction 0 0.650197628 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Vasopressin-regulated water reabsorption 0 0.600790514 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Vibrio cholerae infection 0.911304348 0.924901186 0.862033462 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Viral protein interaction with cytokine and cytokine receptor 0 0 0.464350064 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Wnt signaling pathway 0 0.549407115 0 kegg kegg NA NA no up up no no no Arrhythmogenic right ventricular cardiomyopathy Yersinia infection 0.512173913 0 0.71016731 kegg kegg NA NA no up up no no no Ascorbate and aldarate metabolism Citrate cycle (TCA cycle) 0.592173913 0.603754941 0.711454311 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Fructose and mannose metabolism 0 0 0.53976834 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Galactose metabolism 0.513043478 0 0.576576577 kegg kegg NA NA no no no no no no Ascorbate and aldarate metabolism Pentose and glucuronate interconversions 0.68 0.656126482 0.448391248 kegg kegg NA NA no no no no no no AST+clinic 14:0/18:2-PC+blood -0.500515996 0 0 clinic serum_phospholipids 0.113 0.102 up no no no up no AST+clinic 16:0-LPC+blood 0 0.571428571 0 clinic serum_phospholipids 0.113 0.00456 up no no up up no AST+clinic 16:0/16:0-PC+blood 0 0 -0.520769231 clinic serum_phospholipids 0.113 0.00079 up no no no up up AST+clinic 16:0/18:3-PC+blood 0 0.582142857 0 clinic serum_phospholipids 0.113 0.00216 up no no no up up AST+clinic 16:0/20:5-PC+blood -0.673890609 0 0 clinic serum_phospholipids 0.113 0.628 up no no no no no AST+clinic 16:1/18:2-PG+blood 0 0.639285714 0 clinic serum_phospholipids 0.113 1.40E-08 up no no no up up AST+clinic 16:1+blood 0 0 -0.402307692 yes clinic serum_fattyacid 0.113 0.0186 up no no no no dn AST+clinic 18:0/18:2-PI+blood 0 0.517857143 0 clinic serum_phospholipids 0.113 0.179 up no no no no no AST+clinic 18:1-LPC+blood 0.529411765 0 0.470769231 clinic serum_phospholipids 0.113 0.179 up no no no no no AST+clinic 18:1-LPE+blood 0 0 0.626153846 clinic serum_phospholipids 0.113 0.117 up no no no no no AST+clinic 18:2-LPC+blood 0.479876161 0 0.400769231 clinic serum_phospholipids 0.113 0.00743 up no no dn no up AST+clinic 18:2/20:4-PC+blood 0 0 0.514615385 clinic serum_phospholipids 0.113 0.0145 up no no no no up AST+clinic 20:1+blood 0.469556244 0 0 yes clinic serum_fattyacid 0.113 2.56E-05 up no no dn dn dn AST+clinic 20:2+blood 0.5500516 0 0 clinic serum_fattyacid 0.113 0.478 up no no no no no AST+clinic 20:5n3+blood -0.661506708 0 0 clinic serum_fattyacid 0.113 0.988 up no no no no no AST+clinic 24:1+blood 0 -0.585714286 0 clinic serum_fattyacid 0.113 0.00582 up no no no dn dn AST+clinic ACA+blood 0 -0.629360018 0 clinic serum_bileacids 0.113 0.338 up no no no no no AST+clinic Adipocytokine signaling pathway 0.531338227 0 0 clinic kegg 0.113 NA up no no no no no AST+clinic AGE-RAGE signaling pathway in diabetic complications 0 0.453246753 0 clinic kegg 0.113 NA up no no no no no AST+clinic Alcoholism 0.506493506 0 0 clinic kegg 0.113 NA up no no no no no AST+clinic Betaine+blood 0.494324045 0 0 clinic serum_choline 0.113 0.857 up no no no no no AST+clinic C-peptide -0.420948617 0 0 clinic DM-assocaited hormones 0.113 0.228 up no no no no no AST+clinic Clostridium -0.461082297 0 0 clinic Genus 0.113 0.925 up no no no no no AST+clinic EPA+blood -0.616099071 0 0 clinic serum_ARA 0.113 0.212 up no no no no no AST+clinic Faecalibacterium 0 0 0.441228876 butyrate-producing clinic Genus 0.113 0.0039 up no no no dn dn AST+clinic Ferroptosis 0.583286279 0 0 clinic kegg 0.113 NA up no no no no no AST+clinic GLCA+blood -0.474096828 0 0 clinic serum_bileacids 0.113 0.319 up no no no no no AST+clinic GUDCA+blood 0 0 0.443076923 clinic serum_bileacids 0.113 0.0766 up no no no no dn AST+clinic HCA+stool 0 0 0.53811406 clinic stool_bileacids 0.113 0.155 up no no no no no AST+clinic HDCA+stool 0 0 -0.466967815 clinic stool_bileacids 0.113 0.176 up no no no no no AST+clinic iso-DCA+blood 0 0 -0.407692308 clinic serum_bileacids 0.113 0.38 up no no no no no AST+clinic Kaposi sarcoma-associated herpesvirus infection 0.454545455 0 0 clinic kegg 0.113 NA up no no no no dn AST+clinic L-2-Aminobutyric acid+blood 0 0 -0.413846154 yes clinic serum_aminoacids 0.113 0.000328 up no no up up no AST+clinic LCA+blood 0 0 -0.592546355 clinic serum_bileacids 0.113 0.884 up no no no no no AST+clinic Long-term depression 0.427442123 0 0 clinic kegg 0.113 NA up no no no no no AST+clinic Mineral absorption 0.500846979 0 0 clinic kegg 0.113 NA up no no no no no AST+clinic MIP-1b -0.642857143 0 0 clinic serum_cytokines 0.113 0.632 up no no no no no AST+clinic n3+blood -0.5500516 0 0 clinic serum_fattyacid 0.113 0.806 up no no no no no AST+clinic n6/n3+blood 0.560371517 0 0 clinic serum_fattyacid 0.113 0.226 up no no no no no AST+clinic Necroptosis 0.556182947 0 0 clinic kegg 0.113 NA up no no no no no AST+clinic Ras signaling pathway 0 -0.575324675 0 yes clinic kegg 0.113 NA up no no no up up AST+clinic Salivary secretion 0.494071146 0 0 clinic kegg 0.113 NA up no no no no no AST+clinic SFA+blood 0 0 -0.451538462 clinic serum_fattyacid 0.113 0.0386 up no no up no no AST+clinic ToFA+blood 0 0 -0.459230769 clinic serum_fattyacid 0.113 0.0307 up no no up no dn AST+clinic Toll-like receptor signaling pathway 0 0.436363636 0 yes clinic kegg 0.113 NA up no no no no no AST+clinic UFA+blood 0 0 -0.417692308 clinic serum_fattyacid 0.113 0.0444 up no no up no dn AST+clinic Wnt signaling pathway 0 -0.476623377 0 clinic kegg 0.113 NA up no no no no no Asthma ABC transporters 0 -0.568181818 0 kegg kegg NA NA no no no no up up Asthma Adherens junction 0 0.583003953 0 kegg kegg NA NA no no no no no no Asthma Adipocytokine signaling pathway 0 -0.56916996 0 kegg kegg NA NA no no no no no no Asthma African trypanosomiasis -0.451304348 0 0 kegg kegg NA NA no no no no no no Asthma AMPK signaling pathway 0 -0.457509881 0 kegg kegg NA NA no no no no no no Asthma Apoptosis - multiple species 0 -0.486166008 0 kegg kegg NA NA no no no no no no Asthma Ascorbate and aldarate metabolism 0 0.470355731 0 kegg kegg NA NA no no no no no no Asthma Autophagy - animal 0 -0.506916996 0 kegg kegg NA NA no no no no no no Asthma Autophagy - other 0 -0.46541502 0 kegg kegg NA NA no no no no no no Asthma Bacterial invasion of epithelial cells 0 0.712450593 0 kegg kegg NA NA no no no no no no Asthma beta-Alanine metabolism 0 0.587944664 0.662805663 kegg kegg NA NA no no no no no no Asthma Biosynthesis of unsaturated fatty acids 0 0 0.483397683 kegg kegg NA NA no no no no no no Asthma Breast cancer 0 -0.493083004 0 kegg kegg NA NA no no no no no no Asthma Butanoate metabolism 0 0.446640316 0.427541828 kegg kegg NA NA no no no no no no Asthma cAMP signaling pathway 0 0 -0.48005148 yes kegg kegg NA NA no no no no up up Asthma Carbon metabolism 0 0.686758893 0.409266409 kegg kegg NA NA no no no no no no Asthma Central carbon metabolism in cancer -0.407826087 0 0 kegg kegg NA NA no no no no no no Asthma Chagas disease 0 -0.535573123 -0.408751609 kegg kegg NA NA no no no no no no Asthma Chemical carcinogenesis - receptor activation 0 -0.441699605 0 kegg kegg NA NA no no no no no no Asthma Cholesterol metabolism 0 0.507905138 0 yes kegg kegg NA NA no no no no no up Asthma Choline metabolism in cancer 0 -0.570158103 0 kegg kegg NA NA no no no no no no Asthma Chronic myeloid leukemia 0 0 -0.41029601 kegg kegg NA NA no no no no no no Asthma Citrate cycle (TCA cycle) 0 0.467391304 0 kegg kegg NA NA no no no no no no Asthma Clostridium 0 0.643885059 0 kegg Genus NA 0.925 no no no no no no Asthma Cysteine and methionine metabolism 0 0.435770751 0 kegg kegg NA NA no no no no no no Asthma Drug metabolism - cytochrome P450 0 0.488142292 0.592020592 kegg kegg NA NA no no no no no no Asthma Drug metabolism - other enzymes 0 0.60770751 0 kegg kegg NA NA no no no no no no Asthma ErbB signaling pathway 0 -0.443675889 0 kegg kegg NA NA no no no no no no Asthma Fatty acid elongation 0 0.561264822 0.56988417 kegg kegg NA NA no no no no no no Asthma Focal adhesion 0 0.661067194 0 kegg kegg NA NA no no no no up up Asthma Folate biosynthesis -0.482608696 0 0 kegg kegg NA NA no no no no no no Asthma FoxO signaling pathway 0 -0.505928854 0 kegg kegg NA NA no no no no no no Asthma Gap junction 0 -0.468379447 0 kegg kegg NA NA no no no no no no Asthma Gastric acid secretion 0 0.437747036 0 kegg kegg NA NA no no no no no no Asthma Glutamatergic synapse 0 -0.664031621 0 kegg kegg NA NA no no no no up up Asthma Glycerolipid metabolism 0 -0.454545455 0 kegg kegg NA NA no no no no no up Asthma Glycerophospholipid metabolism 0 -0.542490119 0 kegg kegg NA NA no no no no no up Asthma Glycolysis / Gluconeogenesis 0 0.661067194 0.597940798 kegg kegg NA NA no no no no no no Asthma Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.467391304 0 kegg kegg NA NA no no no no no no Asthma Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 -0.463320463 kegg kegg NA NA no no no no no no Asthma Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.506956522 -0.433794466 0 kegg kegg NA NA no no no no no no Asthma GnRH secretion 0 -0.507905138 0 kegg kegg NA NA no no no no up up Asthma "Growth hormone synthesis, secretion and action" 0 -0.596837945 0 kegg kegg NA NA no no no no no no Asthma Hematopoietic cell lineage 0.664347826 0.853754941 0.853539254 kegg kegg NA NA no no no no no no Asthma Hepatitis C -0.500869565 0 0 kegg kegg NA NA no no no no no no Asthma Hepatocellular carcinoma 0 0.513833992 0 kegg kegg NA NA no no no no no no Asthma Hippo signaling pathway 0 0.559288538 0 kegg kegg NA NA no no no no no no Asthma Histidine metabolism 0 0 0.404890605 kegg kegg NA NA no no no no no no Asthma Influenza A 0.523478261 0.542490119 0.481595882 kegg kegg NA NA no no no no no no Asthma Inositol phosphate metabolism 0 -0.477272727 0 kegg kegg NA NA no no no no no no Asthma Insulin resistance -0.46 -0.447628458 0 kegg kegg NA NA no no no no no no Asthma Intestinal immune network for IgA production 0.664347826 0.790513834 0.827027027 kegg kegg NA NA no no no no no no Asthma JAK-STAT signaling pathway 0 -0.550395257 0 kegg kegg NA NA no no no no no no Asthma Leishmaniasis 0 0.423913043 0.466666667 kegg kegg NA NA no no no no no no Asthma Leukocyte transendothelial migration 0 0.583003953 0 kegg kegg NA NA no no no no no no Asthma Longevity regulating pathway 0 -0.677865613 0 kegg kegg NA NA no no no no no no Asthma Malaria 0.493913043 -0.652173913 0 kegg kegg NA NA no no no no no no Asthma MAPK signaling pathway -0.477391304 0 0 kegg kegg NA NA no no no no no no Asthma Measles -0.6 0 0 kegg kegg NA NA no no no no no no Asthma Melanoma 0 -0.5 0 kegg kegg NA NA no no no no no no Asthma Metabolism of xenobiotics by cytochrome P450 0 0.575098814 0.56962677 kegg kegg NA NA no no no no no no Asthma MicroRNAs in cancer 0 -0.43083004 0 kegg kegg NA NA no no no no no no Asthma NF-kappa B signaling pathway 0 -0.434782609 0 kegg kegg NA NA no no no no no no Asthma Nicotine addiction 0 -0.456521739 0 kegg kegg NA NA no no no no up up Asthma Nitrogen metabolism 0 -0.429841897 0 kegg kegg NA NA no no no no no no Asthma Non-homologous end-joining 0 0.514822134 0 kegg kegg NA NA no no no no no no Asthma Non-small cell lung cancer 0 -0.609683794 0 kegg kegg NA NA no no no no no no Asthma Notch signaling pathway 0 -0.419960474 0 kegg kegg NA NA no no no no no no Asthma Oocyte meiosis 0 0.453557312 0 kegg kegg NA NA no no no no no no Asthma Other types of O-glycan biosynthesis -0.453913043 -0.422924901 0 kegg kegg NA NA no no no no no no Asthma p53 signaling pathway 0 -0.618577075 0 kegg kegg NA NA no no no no no no Asthma Pathways in cancer 0 -0.633399209 -0.407979408 kegg kegg NA NA no no no no no no Asthma PD-L1 expression and PD-1 checkpoint pathway in cancer -0.437391304 -0.471343874 -0.422908623 kegg kegg NA NA no no no no no no Asthma Phenylalanine metabolism 0 0.442687747 0 kegg kegg NA NA no no no no no no Asthma Phospholipase D signaling pathway 0 -0.574110672 -0.426254826 kegg kegg NA NA no no no no up up Asthma Phototransduction 0 0.592885375 0 kegg kegg NA NA no no no no no no Asthma PI3K-Akt signaling pathway -0.529565217 0 0 yes kegg kegg NA NA no no no no up up Asthma Platelet activation 0 0.499011858 0 kegg kegg NA NA no no no no no no Asthma Primary bile acid biosynthesis 0 0.508893281 0.500900901 kegg kegg NA NA no no no no no no Asthma Progesterone-mediated oocyte maturation -0.451304348 -0.477272727 0 kegg kegg NA NA no no no no no no Asthma Propanoate metabolism 0 0.454545455 0 kegg kegg NA NA no no no no no no Asthma Prostate cancer 0 0 -0.405148005 kegg kegg NA NA no no no no no no Asthma Proteasome 0 0.622529644 0 kegg kegg NA NA no no no no no no Asthma Protein digestion and absorption 0.447826087 0 0 yes kegg kegg NA NA no no no no up up Asthma Protein export 0 0.419960474 0 kegg kegg NA NA no no no no no no Asthma Rap1 signaling pathway 0 0.435770751 0 kegg kegg NA NA no no no no no no Asthma Regulation of actin cytoskeleton 0 0.602766798 0 kegg kegg NA NA no no no no no no Asthma Relaxin signaling pathway 0 -0.463438735 0 kegg kegg NA NA no no no no no no Asthma RIG-I-like receptor signaling pathway 0 -0.41798419 0 kegg kegg NA NA no no no no no no Asthma Salmonella infection 0 0 0.404375804 kegg kegg NA NA no no no no no no Asthma Small cell lung cancer 0 0 -0.466924067 kegg kegg NA NA no no no no no up Asthma Sphingolipid metabolism 0 0.515810277 0 kegg kegg NA NA no no no no no no Asthma Spliceosome 0 -0.434782609 0 kegg kegg NA NA no no no no no no Asthma Staphylococcus aureus infection 0.493043478 0.496047431 0.51994852 kegg kegg NA NA no no no up no no Asthma Steroid hormone biosynthesis 0 0.42687747 0 kegg kegg NA NA no no no no no no Asthma T cell receptor signaling pathway -0.630434783 0 0 kegg kegg NA NA no no no no no no Asthma Taste transduction -0.545217391 0 0 kegg kegg NA NA no no no no no up Asthma Taurine and hypotaurine metabolism 0 -0.568181818 0 kegg kegg NA NA no no no no no no Asthma TGF-beta signaling pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Asthma Th1 and Th2 cell differentiation 0.532173913 0 0.658172458 kegg kegg NA NA no no no no no no Asthma Th17 cell differentiation 0.504347826 0 0.694723295 kegg kegg NA NA no no no no no no Asthma Thyroid hormone signaling pathway 0 0.42687747 0 kegg kegg NA NA no no no no no no Asthma Tight junction 0 0.604743083 0 kegg kegg NA NA no no no no no no Asthma Toxoplasmosis 0.56 0.45256917 0.841441441 kegg kegg NA NA no no no no no no Asthma Transcriptional misregulation in cancer 0 -0.486166008 -0.425225225 kegg kegg NA NA no no no no no no Asthma Tryptophan metabolism 0 0.58201581 0 kegg kegg NA NA no no no no up no Asthma Tuberculosis 0.453913043 0 0.538996139 kegg kegg NA NA no no no no no dn Asthma Type I diabetes mellitus 0.448695652 0 0 kegg kegg NA NA no no no no no no Asthma Vibrio cholerae infection 0 0.468379447 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease 2-Oxocarboxylic acid metabolism 0.462608696 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Adrenergic signaling in cardiomyocytes 0 -0.43972332 0 kegg kegg NA NA no no no no no up Autoimmune thyroid disease Aldosterone synthesis and secretion 0 -0.612648221 0 kegg kegg NA NA no no no no up up Autoimmune thyroid disease Alzheimer disease -0.507826087 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Amino sugar and nucleotide sugar metabolism 0 0 -0.411840412 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Amphetamine addiction -0.426086957 -0.684782609 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease AMPK signaling pathway 0 -0.665019763 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Amyotrophic lateral sclerosis -0.455652174 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Antifolate resistance 0 0 -0.455598456 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Antigen processing and presentation 0.469565217 0.533596838 0.645817246 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Apelin signaling pathway -0.459130435 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Apoptosis 0 0.710474308 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Apoptosis - multiple species 0 0 -0.555469755 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Asthma 0.448695652 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Autophagy - other -0.580869565 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease B cell receptor signaling pathway 0 0.472332016 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Bacteroides 0.433043478 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Autoimmune thyroid disease Basal transcription factors -0.592173913 -0.584980237 -0.535649936 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Base excision repair 0 -0.530632411 -0.436550837 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Biosynthesis of amino acids 0.570434783 0.587944664 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Biosynthesis of cofactors 0 -0.843873518 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Butyricicoccus 0 0 0.471212756 butyrate-producing kegg Genus NA 0.852 no no no no no no Autoimmune thyroid disease C-type lectin receptor signaling pathway 0 0.523715415 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease cAMP signaling pathway -0.452173913 0 0 yes kegg kegg NA NA no no no no up up Autoimmune thyroid disease Carbon metabolism 0.477391304 0.475296443 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Cardiac muscle contraction -0.428695652 0 0 kegg kegg NA NA no no no no no up Autoimmune thyroid disease Cell adhesion molecules 0.957391304 0.960474308 0.942599743 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Cell cycle -0.607826087 -0.612648221 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Cellular senescence 0.830434783 0.935770751 0.886486486 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Central carbon metabolism in cancer 0 0 -0.444530245 kegg kegg NA NA no no no no no no Autoimmune thyroid disease cGMP-PKG signaling pathway 0 0.528656126 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Chemical carcinogenesis - receptor activation -0.535652174 -0.588932806 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Chemokine signaling pathway 0 0.451581028 0.466666667 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Cholesterol metabolism 0 0.708498024 0 yes kegg kegg NA NA no no no no no up Autoimmune thyroid disease Circadian rhythm -0.499130435 -0.504940711 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Cocaine addiction 0 -0.522727273 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Complement and coagulation cascades 0.528695652 0.57312253 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Cortisol synthesis and secretion 0 -0.627470356 0 kegg kegg NA NA no no no no no up Autoimmune thyroid disease Cushing syndrome 0 -0.698616601 0 kegg kegg NA NA no no no no no up Autoimmune thyroid disease Cytosolic DNA-sensing pathway 0 0 0.47979408 kegg kegg NA NA no no no no no no Autoimmune thyroid disease DNA replication 0 -0.418972332 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Dopaminergic synapse -0.44 -0.524703557 0 kegg kegg NA NA no no no no up no Autoimmune thyroid disease Endocrine and other factor-regulated calcium reabsorption 0 -0.468379447 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Endocrine resistance 0 -0.563241107 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Endocytosis 0.833043478 0.944664032 0.909137709 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Epithelial cell signaling in Helicobacter pylori infection 0 0.577075099 0.542084942 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Epstein-Barr virus infection 0.475652174 0.544466403 0.736422136 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Estrogen signaling pathway -0.426956522 -0.490118577 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Ether lipid metabolism -0.502608696 -0.698616601 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Fanconi anemia pathway 0 -0.563241107 -0.463320463 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Fc epsilon RI signaling pathway 0 0.576086957 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Fc gamma R-mediated phagocytosis 0 0.546442688 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Folate biosynthesis -0.459130435 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease FoxO signaling pathway 0 0 -0.534877735 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Glucagon signaling pathway 0 -0.62944664 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Glutathione metabolism 0 -0.540513834 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Glycerophospholipid metabolism -0.487826087 -0.472332016 0 kegg kegg NA NA no no no no no up Autoimmune thyroid disease "Glycine, serine and threonine metabolism" 0 -0.780632411 0 kegg kegg NA NA no no no no up no Autoimmune thyroid disease Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.424347826 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Glycosaminoglycan degradation 0 0.624505929 0 kegg kegg NA NA no no no no no up Autoimmune thyroid disease Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.752964427 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease GnRH signaling pathway 0 -0.553359684 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Hedgehog signaling pathway 0 -0.446640316 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Herpes simplex virus 1 infection 0 0.53458498 0.68957529 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Homologous recombination 0 -0.505928854 -0.532818533 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Human cytomegalovirus infection 0.42173913 0.535573123 0.682625483 kegg kegg NA NA no no no no no dn Autoimmune thyroid disease Human immunodeficiency virus 1 infection 0 0.53458498 0.665894466 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Human papillomavirus infection 0.839130435 0.90513834 0.841698842 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Human T-cell leukemia virus 1 infection 0.471304348 0.519762846 0.714543115 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Huntington disease -0.474782609 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease IL-17 signaling pathway 0 0.563241107 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Inflammatory mediator regulation of TRP channels 0 -0.421936759 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Influenza A 0.605217391 0.770750988 0.544401544 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Insulin resistance -0.462608696 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Insulin secretion 0 -0.570158103 0 yes kegg kegg NA NA no no no no up up Autoimmune thyroid disease Insulin signaling pathway -0.450434783 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Leukocyte transendothelial migration 0.511304348 0.506916996 0.413127413 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Long-term potentiation -0.473913043 0 0 kegg kegg NA NA no no no no no up Autoimmune thyroid disease Longevity regulating pathway 0 -0.471343874 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Lysosome 0 0.704545455 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease MAPK signaling pathway -0.595652174 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Maturity onset diabetes of the young 0 -0.513833992 0 kegg kegg NA NA no no no no up no Autoimmune thyroid disease Measles -0.502608696 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Mismatch repair 0 -0.545454545 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Mitophagy - animal 0 -0.491106719 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Morphine addiction 0 -0.428853755 0 kegg kegg NA NA no no no no up up Autoimmune thyroid disease mRNA surveillance pathway -0.593043478 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Natural killer cell mediated cytotoxicity 0.822608696 0.95256917 0.8998713 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Neuroactive ligand-receptor interaction 0 0.615612648 0 kegg kegg NA NA no no no up up up Autoimmune thyroid disease Neurotrophin signaling pathway 0 0.492094862 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Neutrophil extracellular trap formation 0.406086957 0.612648221 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease NOD-like receptor signaling pathway 0 0.490118577 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Non-alcoholic fatty liver disease -0.504347826 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Nucleotide excision repair 0 -0.589920949 -0.535907336 kegg kegg NA NA no no no no no no Autoimmune thyroid disease One carbon pool by folate 0 -0.546442688 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Oocyte meiosis -0.542608696 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Osteoclast differentiation 0 0.588932806 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Other types of O-glycan biosynthesis -0.529565217 -0.53458498 -0.400514801 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Ovarian steroidogenesis 0 -0.457509881 0 kegg kegg NA NA no no no no up up Autoimmune thyroid disease Oxidative phosphorylation -0.460869565 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease p53 signaling pathway -0.511304348 -0.491106719 -0.543886744 kegg kegg NA NA no no no no no no Autoimmune thyroid disease "Parathyroid hormone synthesis, secretion and action" -0.406086957 -0.434782609 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Pathogenic Escherichia coli infection 0 0.7756917 0.474646075 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Pathways in cancer -0.551304348 0 -0.441698842 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Pentose phosphate pathway 0.453043478 0.663043478 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Pertussis 0 0.649209486 0 kegg kegg NA NA no no no no no dn Autoimmune thyroid disease Phagosome 0.895652174 0.916007905 0.814929215 kegg kegg NA NA no no no no no no Autoimmune thyroid disease PI3K-Akt signaling pathway -0.53826087 0 0 yes kegg kegg NA NA no no no no up up Autoimmune thyroid disease Platinum drug resistance 0 0 -0.578635779 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Porphyrin and chlorophyll metabolism 0 -0.745059289 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease PPAR signaling pathway 0 0.457509881 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Prion disease -0.459130435 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Progesterone-mediated oocyte maturation -0.429565217 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Prolactin signaling pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Protein digestion and absorption 0.426086957 0.456521739 0 yes kegg kegg NA NA no no no no up up Autoimmune thyroid disease Protein export -0.557391304 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Protein processing in endoplasmic reticulum 0 -0.471343874 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Proximal tubule bicarbonate reclamation 0 0 -0.402831403 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Purine metabolism 0 -0.751976285 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Pyrimidine metabolism 0 -0.423913043 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Pyruvate metabolism 0 -0.431818182 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Renin-angiotensin system 0 0.677865613 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Retinol metabolism 0 -0.414031621 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Retrograde endocannabinoid signaling -0.517391304 0 0 kegg kegg NA NA no no no no no up Autoimmune thyroid disease Ribosome biogenesis in eukaryotes -0.432173913 -0.536561265 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease RNA degradation -0.503478261 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease RNA polymerase -0.46173913 -0.570158103 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Ruminococcus 0 0 0.405662806 acetate-producing kegg Genus NA 0.335 no no no no no no Autoimmune thyroid disease Salmonella infection 0 0.706521739 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Selenocompound metabolism -0.53826087 -0.531620553 -0.468725869 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Sphingolipid metabolism 0 0.445652174 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Sphingolipid signaling pathway 0 0.713438735 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Spliceosome -0.415652174 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Staphylococcus aureus infection 0.569565217 0.731225296 0 kegg kegg NA NA no no no up no no Autoimmune thyroid disease Steroid biosynthesis -0.605217391 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Synaptic vesicle cycle 0 0.462450593 0 kegg kegg NA NA no no no no up up Autoimmune thyroid disease Synthesis and degradation of ketone bodies 0 -0.589920949 -0.425740026 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Taste transduction -0.659130435 -0.586956522 0 kegg kegg NA NA no no no no no up Autoimmune thyroid disease Taurine and hypotaurine metabolism -0.414782609 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Terpenoid backbone biosynthesis -0.695652174 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Th1 and Th2 cell differentiation 0 0.570158103 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Th17 cell differentiation 0 0.540513834 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Thermogenesis -0.436521739 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Thiamine metabolism 0 -0.592885375 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Thyroid hormone synthesis 0 -0.496047431 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Toll-like receptor signaling pathway 0 0.48715415 0.462548263 yes kegg kegg NA NA no no no no no no Autoimmune thyroid disease Toxoplasmosis 0 0.563241107 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Tuberculosis 0.476521739 0.698616601 0 kegg kegg NA NA no no no no no dn Autoimmune thyroid disease Type I diabetes mellitus 1 0.999011858 0.999485199 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Tyrosine metabolism 0 -0.449604743 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.449604743 -0.424967825 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Ubiquitin mediated proteolysis 0 -0.555335968 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Vasopressin-regulated water reabsorption 0 -0.425889328 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Viral carcinogenesis 0.803478261 0.916996047 0.856370656 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Vitamin digestion and absorption -0.532173913 0 0 kegg kegg NA NA no no no no no no Autoimmune thyroid disease Yersinia infection 0 0.713438735 0.407207207 kegg kegg NA NA no no no no no no Autophagy - animal 2-Oxocarboxylic acid metabolism -0.553043478 -0.628458498 0 kegg kegg NA NA no no no no no no Autophagy - animal ABC transporters 0 0.485177866 0 kegg kegg NA NA no no no no up up Autophagy - animal "Alanine, aspartate and glutamate metabolism" 0.58173913 0.836956522 0 kegg kegg NA NA no no no no no no Autophagy - animal Alistipes -0.523149093 0 0 kegg Genus NA 0.0114 no no no no up no Autophagy - animal alpha-Linolenic acid metabolism 0 0.473320158 0 kegg kegg NA NA no no no no no no Autophagy - animal Arachidonic acid metabolism -0.509565217 0 0 kegg kegg NA NA no no no no no no Autophagy - animal Arginine and proline metabolism 0 0.77173913 0 kegg kegg NA NA no no no no up no Autophagy - animal Arginine biosynthesis 0.490434783 0.7756917 0 kegg kegg NA NA no no no no no no Autophagy - animal Ascorbate and aldarate metabolism 0 -0.463438735 0 kegg kegg NA NA no no no no no no Autophagy - animal Autophagy - other 0.756521739 0.656126482 0.512226512 kegg kegg NA NA no no no no no no Autophagy - animal beta-Alanine metabolism -0.430434783 -0.505928854 0 kegg kegg NA NA no no no no no no Autophagy - animal Bifidobacterium 0 -0.473503186 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Autophagy - animal Biosynthesis of amino acids 0 0.442687747 0 kegg kegg NA NA no no no no no no Autophagy - animal Biosynthesis of cofactors -0.589565217 0 0 kegg kegg NA NA no no no no no no Autophagy - animal Butanoate metabolism -0.446956522 -0.746047431 0 kegg kegg NA NA no no no no no no Autophagy - animal cAMP signaling pathway 0 0.438735178 0 yes kegg kegg NA NA no no no no up up Autophagy - animal Carbon metabolism -0.411304348 0 0 kegg kegg NA NA no no no no no no Autophagy - animal cGMP-PKG signaling pathway 0.625217391 0.520750988 0.408236808 kegg kegg NA NA no no no no no no Autophagy - animal Chemokine signaling pathway 0 0.460474308 0 kegg kegg NA NA no no no no no no Autophagy - animal Citrate cycle (TCA cycle) 0 -0.744071146 0 kegg kegg NA NA no no no no no no Autophagy - animal Cysteine and methionine metabolism 0 -0.703557312 0 kegg kegg NA NA no no no no no no Autophagy - animal Cytokine-cytokine receptor interaction 0 0 -0.477220077 kegg kegg NA NA no no no no no no Autophagy - animal DNA replication 0 -0.670948617 0 kegg kegg NA NA no no no no no no Autophagy - animal Drug metabolism - cytochrome P450 0 -0.831027668 0 kegg kegg NA NA no no no no no no Autophagy - animal Drug metabolism - other enzymes 0 -0.880434783 0 kegg kegg NA NA no no no no no no Autophagy - animal EGFR tyrosine kinase inhibitor resistance 0 -0.529644269 0 kegg kegg NA NA no no no no no no Autophagy - animal ErbB signaling pathway 0.546956522 0.668972332 0.650965251 kegg kegg NA NA no no no no no no Autophagy - animal Fatty acid biosynthesis 0.543478261 0.774703557 0.498069498 kegg kegg NA NA no no no no no no Autophagy - animal Fatty acid degradation 0 0.598814229 0 kegg kegg NA NA no no no no no no Autophagy - animal Fatty acid elongation -0.473043478 -0.501976285 0 kegg kegg NA NA no no no no no no Autophagy - animal Fatty acid metabolism 0 0.497035573 0 kegg kegg NA NA no no no no no no Autophagy - animal Folate biosynthesis 0 -0.449604743 0 kegg kegg NA NA no no no no no no Autophagy - animal FoxO signaling pathway 0.697391304 0.749011858 0.430630631 kegg kegg NA NA no no no no no no Autophagy - animal Fructose and mannose metabolism 0 0.497035573 0 kegg kegg NA NA no no no no no no Autophagy - animal Galactose metabolism 0 0.500988142 0 kegg kegg NA NA no no no no no no Autophagy - animal Glutathione metabolism -0.527826087 -0.589920949 -0.467953668 kegg kegg NA NA no no no no no no Autophagy - animal Glycerolipid metabolism 0 0.572134387 0 kegg kegg NA NA no no no no no up Autophagy - animal Glycerophospholipid metabolism 0.484347826 0.52173913 0 kegg kegg NA NA no no no no no up Autophagy - animal "Glycine, serine and threonine metabolism" -0.592173913 0 0 kegg kegg NA NA no no no no up no Autophagy - animal Glycolysis / Gluconeogenesis 0 -0.735177866 0 kegg kegg NA NA no no no no no no Autophagy - animal Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.474782609 0.863636364 0.406692407 kegg kegg NA NA no no no no no no Autophagy - animal Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.599130435 0 0 kegg kegg NA NA no no no no no no Autophagy - animal Glyoxylate and dicarboxylate metabolism 0 0.777667984 0 kegg kegg NA NA no no no no no no Autophagy - animal HIF-1 signaling pathway 0 -0.586956522 0 kegg kegg NA NA no no no no no no Autophagy - animal Inositol phosphate metabolism 0 0.515810277 0 kegg kegg NA NA no no no no no no Autophagy - animal Lachnospira 0 -0.551519661 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Autophagy - animal Linoleic acid metabolism 0 -0.443675889 0 kegg kegg NA NA no no no no no no Autophagy - animal MAPK signaling pathway 0.534782609 0.497035573 0.581467181 kegg kegg NA NA no no no no no no Autophagy - animal Metabolism of xenobiotics by cytochrome P450 0 -0.846837945 0 kegg kegg NA NA no no no no no no Autophagy - animal Mismatch repair 0 -0.56027668 0 kegg kegg NA NA no no no no no no Autophagy - animal Mucin type O-glycan biosynthesis 0 0.423913043 0 kegg kegg NA NA no no no no no no Autophagy - animal N-Glycan biosynthesis 0 -0.670948617 0 kegg kegg NA NA no no no no no no Autophagy - animal NF-kappa B signaling pathway 0.58173913 0.93083004 0.465637066 kegg kegg NA NA no no no no no no Autophagy - animal Nicotinate and nicotinamide metabolism 0.524347826 0.752964427 0.408494208 kegg kegg NA NA no no no no no no Autophagy - animal Nitrogen metabolism 0 0.749011858 0 kegg kegg NA NA no no no no no no Autophagy - animal Non-homologous end-joining -0.412173913 -0.558300395 0 kegg kegg NA NA no no no no no no Autophagy - animal Nucleotide excision repair 0 -0.538537549 0 kegg kegg NA NA no no no no no no Autophagy - animal One carbon pool by folate 0 -0.588932806 0 kegg kegg NA NA no no no no no no Autophagy - animal Oocyte meiosis 0 -0.645256917 0 kegg kegg NA NA no no no no no no Autophagy - animal Oscillospira 0 0.441699605 0 LPS-producing kegg Genus NA 0.62 no no no no no no Autophagy - animal Other glycan degradation 0 0.482213439 0 kegg kegg NA NA no no no no no no Autophagy - animal Oxidative phosphorylation 0 -0.721343874 -0.492921493 kegg kegg NA NA no no no no no no Autophagy - animal p53 signaling pathway 0.633043478 0.445652174 0 kegg kegg NA NA no no no no no no Autophagy - animal Pantothenate and CoA biosynthesis 0.460869565 0.639328063 0.45019305 kegg kegg NA NA no no no no no dn Autophagy - animal Paraprevotella -0.410684451 0 0 kegg Genus NA 0.118 no no no no no no Autophagy - animal Pentose and glucuronate interconversions -0.516521739 -0.740118577 0 kegg kegg NA NA no no no no no no Autophagy - animal Phenylalanine metabolism -0.737391304 -0.767786561 0 kegg kegg NA NA no no no no no no Autophagy - animal Phospholipase D signaling pathway 0 0.720355731 0 kegg kegg NA NA no no no no up up Autophagy - animal Platinum drug resistance 0.577391304 0.415019763 0.454311454 kegg kegg NA NA no no no no no no Autophagy - animal Porphyrin and chlorophyll metabolism -0.527826087 0 0 kegg kegg NA NA no no no no no no Autophagy - animal PPAR signaling pathway 0 0.729249012 0 kegg kegg NA NA no no no no no no Autophagy - animal Prevotella 0 0.467631712 0 acetate-producing kegg Genus NA 0.287 no no no no no no Autophagy - animal Primary bile acid biosynthesis 0 -0.506916996 0 kegg kegg NA NA no no no no no no Autophagy - animal Propanoate metabolism 0 -0.671936759 0 kegg kegg NA NA no no no no no no Autophagy - animal Proteasome 0 -0.701581028 0 kegg kegg NA NA no no no no no no Autophagy - animal Protein export 0 -0.711462451 0 kegg kegg NA NA no no no no no no Autophagy - animal Pyrimidine metabolism 0 -0.646245059 0 kegg kegg NA NA no no no no no no Autophagy - animal Pyruvate metabolism 0 -0.733201581 0 kegg kegg NA NA no no no no no no Autophagy - animal Rap1 signaling pathway -0.527826087 -0.622529644 -0.461261261 kegg kegg NA NA no no no no no no Autophagy - animal Ras signaling pathway 0 -0.684782609 0 yes kegg kegg NA NA no no no no up up Autophagy - animal Retinol metabolism 0 -0.479249012 0 kegg kegg NA NA no no no no no no Autophagy - animal Ribosome 0 -0.660079051 -0.426512227 kegg kegg NA NA no no no no no no Autophagy - animal RNA degradation 0 -0.59486166 0 kegg kegg NA NA no no no no no no Autophagy - animal RNA polymerase 0 -0.486166008 0 kegg kegg NA NA no no no no no no Autophagy - animal RNA transport 0 -0.46541502 0 kegg kegg NA NA no no no no no no Autophagy - animal Selenocompound metabolism 0.525217391 0 0 kegg kegg NA NA no no no no no no Autophagy - animal SNARE interactions in vesicular transport 0 0.679841897 0 kegg kegg NA NA no no no no no no Autophagy - animal Sphingolipid signaling pathway 0.58173913 0.449604743 0.46023166 kegg kegg NA NA no no no no no no Autophagy - animal Spliceosome 0.499130435 0 0 kegg kegg NA NA no no no no no no Autophagy - animal Starch and sucrose metabolism 0 0.661067194 0 kegg kegg NA NA no no no no no no Autophagy - animal Steroid biosynthesis 0 -0.524703557 0 kegg kegg NA NA no no no no no no Autophagy - animal Steroid hormone biosynthesis 0 -0.563241107 0 kegg kegg NA NA no no no no no no Autophagy - animal Sulfur metabolism -0.495652174 0 0 kegg kegg NA NA no no no no no no Autophagy - animal Synthesis and degradation of ketone bodies 0 -0.453557312 0 kegg kegg NA NA no no no no no no Autophagy - animal Taurine and hypotaurine metabolism 0.488695652 0.646245059 0 kegg kegg NA NA no no no no no no Autophagy - animal Thiamine metabolism 0 -0.535573123 0 kegg kegg NA NA no no no no no no Autophagy - animal Tryptophan metabolism 0 -0.614624506 0 kegg kegg NA NA no no no no up no Autophagy - animal Tyrosine metabolism -0.506086957 -0.733201581 0 kegg kegg NA NA no no no no no no Autophagy - animal Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.550395257 0 kegg kegg NA NA no no no no no no Autophagy - animal Ubiquitin mediated proteolysis 0 -0.457509881 0 kegg kegg NA NA no no no no no no Autophagy - animal "Valine, leucine and isoleucine degradation" 0 -0.672924901 0 kegg kegg NA NA no no no no no no Autophagy - animal Various types of N-glycan biosynthesis 0 -0.484189723 0 kegg kegg NA NA no no no no no no Autophagy - animal Viral protein interaction with cytokine and cytokine receptor 0 0 -0.587902188 kegg kegg NA NA no no no no no no Autophagy - other 2-Oxocarboxylic acid metabolism -0.424347826 0 0 kegg kegg NA NA no no no no no no Autophagy - other ABC transporters 0 0.638339921 0 kegg kegg NA NA no no no no up up Autophagy - other Arachidonic acid metabolism 0 -0.523715415 -0.710682111 kegg kegg NA NA no no no no no no Autophagy - other Basal transcription factors 0.744347826 0 0.671042471 kegg kegg NA NA no no no no no no Autophagy - other Base excision repair 0.543478261 0 0 kegg kegg NA NA no no no no no no Autophagy - other beta-Alanine metabolism -0.51826087 0 0 kegg kegg NA NA no no no no no no Autophagy - other Biosynthesis of amino acids -0.471304348 0 -0.562676963 kegg kegg NA NA no no no no no no Autophagy - other Biosynthesis of cofactors -0.433913043 0 -0.446846847 kegg kegg NA NA no no no no no no Autophagy - other Calcium signaling pathway 0 0 0.411068211 kegg kegg NA NA no no no no up up Autophagy - other cAMP signaling pathway 0.467826087 0 0 yes kegg kegg NA NA no no no no up up Autophagy - other Carbon metabolism -0.47826087 -0.493083004 -0.44967825 kegg kegg NA NA no no no no no no Autophagy - other Cell cycle 0.497391304 0 0.625225225 kegg kegg NA NA no no no no no no Autophagy - other Cytokine-cytokine receptor interaction 0 -0.431818182 -0.432432432 kegg kegg NA NA no no no no no no Autophagy - other DNA replication 0 0 0.44041184 kegg kegg NA NA no no no no no no Autophagy - other Drug metabolism - other enzymes 0 -0.43972332 0 kegg kegg NA NA no no no no no no Autophagy - other EGFR tyrosine kinase inhibitor resistance 0.554782609 0 0 kegg kegg NA NA no no no no no no Autophagy - other ErbB signaling pathway 0.466956522 0.559288538 0.693436293 kegg kegg NA NA no no no no no no Autophagy - other Fanconi anemia pathway 0 0 0.522522523 kegg kegg NA NA no no no no no no Autophagy - other Fatty acid elongation -0.429565217 0 0 kegg kegg NA NA no no no no no no Autophagy - other FoxO signaling pathway 0.408695652 0.579051383 0 kegg kegg NA NA no no no no no no Autophagy - other Galactose metabolism -0.473913043 0 0 kegg kegg NA NA no no no no no no Autophagy - other Glutathione metabolism 0 0 -0.648906049 kegg kegg NA NA no no no no no no Autophagy - other Glycerolipid metabolism 0 0.586956522 0.495752896 kegg kegg NA NA no no no no no up Autophagy - other Glycerophospholipid metabolism 0.432173913 0.651185771 0.579150579 kegg kegg NA NA no no no no no up Autophagy - other "Glycine, serine and threonine metabolism" -0.416521739 0 -0.451480051 kegg kegg NA NA no no no no up no Autophagy - other Glycolysis / Gluconeogenesis 0 -0.482213439 0 kegg kegg NA NA no no no no no no Autophagy - other Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.432806324 0 kegg kegg NA NA no no no no no no Autophagy - other Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.526086957 0 0 kegg kegg NA NA no no no no no no Autophagy - other Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.514543115 kegg kegg NA NA no no no no no no Autophagy - other Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 0.401287001 kegg kegg NA NA no no no no no no Autophagy - other HIF-1 signaling pathway 0.572173913 0 0 kegg kegg NA NA no no no no no no Autophagy - other Homologous recombination 0 0.599802372 0.457142857 kegg kegg NA NA no no no no no no Autophagy - other Inositol phosphate metabolism 0 0.657114625 0.451737452 kegg kegg NA NA no no no no no no Autophagy - other Lysine degradation 0.572173913 0.683794466 0.726383526 kegg kegg NA NA no no no no no no Autophagy - other Mannose type O-glycan biosynthesis 0 0.611660079 0.659202059 kegg kegg NA NA no no no no no no Autophagy - other MAPK signaling pathway 0 0.545454545 0.521750322 kegg kegg NA NA no no no no no no Autophagy - other mRNA surveillance pathway 0.652173913 0 0.727155727 kegg kegg NA NA no no no no no no Autophagy - other Mucin type O-glycan biosynthesis 0 0.75 0 kegg kegg NA NA no no no no no no Autophagy - other N-Glycan biosynthesis 0 0 0.555212355 kegg kegg NA NA no no no no no no Autophagy - other NF-kappa B signaling pathway 0 0.558300395 0 kegg kegg NA NA no no no no no no Autophagy - other Oocyte meiosis 0.511304348 0 0.515057915 kegg kegg NA NA no no no no no no Autophagy - other Other glycan degradation 0 0.674901186 0 kegg kegg NA NA no no no no no no Autophagy - other Other types of O-glycan biosynthesis 0.584347826 0.618577075 0.673359073 kegg kegg NA NA no no no no no no Autophagy - other p53 signaling pathway 0.70173913 0.668972332 0.453796654 kegg kegg NA NA no no no no no no Autophagy - other Pentose phosphate pathway -0.428695652 0 -0.485456885 kegg kegg NA NA no no no no no no Autophagy - other Phenylalanine metabolism -0.667826087 0 0 kegg kegg NA NA no no no no no no Autophagy - other Phosphatidylinositol signaling system 0.49826087 0 0.687773488 kegg kegg NA NA no no no no no no Autophagy - other Platinum drug resistance 0.595652174 0.714426877 0.513256113 kegg kegg NA NA no no no no no no Autophagy - other Porphyrin and chlorophyll metabolism -0.407826087 0 -0.466924067 kegg kegg NA NA no no no no no no Autophagy - other Proteasome 0.49826087 0 0 kegg kegg NA NA no no no no no no Autophagy - other Protein export 0.68 0 0.52998713 kegg kegg NA NA no no no no no no Autophagy - other Rap1 signaling pathway -0.734782609 -0.805335968 -0.55032175 kegg kegg NA NA no no no no no no Autophagy - other Ras signaling pathway 0 0 0.553667954 yes kegg kegg NA NA no no no no up up Autophagy - other Ribosome 0.453913043 0 0 kegg kegg NA NA no no no no no no Autophagy - other Ribosome biogenesis in eukaryotes 0.570434783 0 0.611068211 kegg kegg NA NA no no no no no no Autophagy - other RNA degradation 0.633043478 0 0.736422136 kegg kegg NA NA no no no no no no Autophagy - other RNA polymerase 0.667826087 0 0.405662806 kegg kegg NA NA no no no no no no Autophagy - other RNA transport 0.42173913 0 0 kegg kegg NA NA no no no no no no Autophagy - other Selenocompound metabolism 0.644347826 0.548418972 0.494465894 kegg kegg NA NA no no no no no no Autophagy - other SNARE interactions in vesicular transport 0 0.747035573 0 kegg kegg NA NA no no no no no no Autophagy - other Sphingolipid signaling pathway 0.433043478 0 0.427284427 kegg kegg NA NA no no no no no no Autophagy - other Spliceosome 0.766086957 0.807312253 0.761132561 kegg kegg NA NA no no no no no no Autophagy - other Sulfur metabolism -0.544347826 0 -0.527670528 kegg kegg NA NA no no no no no no Autophagy - other Taurine and hypotaurine metabolism 0 0.590909091 0.438610039 kegg kegg NA NA no no no no no no Autophagy - other Terpenoid backbone biosynthesis 0.54173913 0 0.543886744 kegg kegg NA NA no no no no no no Autophagy - other Tyrosine metabolism -0.422608696 0 0 kegg kegg NA NA no no no no no no Autophagy - other Various types of N-glycan biosynthesis 0.566956522 0 0.609009009 kegg kegg NA NA no no no no no no Autophagy - other Viral protein interaction with cytokine and cytokine receptor 0 -0.553359684 -0.438095238 kegg kegg NA NA no no no no no no Axon guidance 2-Oxocarboxylic acid metabolism -0.556521739 0 0 kegg kegg NA NA no up up no no no Axon guidance ABC transporters -0.44173913 -0.508893281 0 kegg kegg NA NA no up up no up up Axon guidance Adrenergic signaling in cardiomyocytes 0.6 0 0 kegg kegg NA NA no up up no no up Axon guidance alpha-Linolenic acid metabolism -0.584347826 -0.491106719 0 kegg kegg NA NA no up up no no no Axon guidance Amino sugar and nucleotide sugar metabolism -0.710434783 -0.64229249 -0.476705277 kegg kegg NA NA no up up no no no Axon guidance Aminoacyl-tRNA biosynthesis -0.580869565 -0.526679842 0 kegg kegg NA NA no up up no no no Axon guidance Antifolate resistance -0.585217391 -0.450592885 0 kegg kegg NA NA no up up no no no Axon guidance Apoptosis - multiple species 0 -0.507905138 0 kegg kegg NA NA no up up no no no Axon guidance Arachidonic acid metabolism -0.466086957 0 -0.507850708 kegg kegg NA NA no up up no no no Axon guidance Ascorbate and aldarate metabolism -0.492173913 0 0 kegg kegg NA NA no up up no no no Axon guidance Autophagy - animal 0 0 0.412355212 kegg kegg NA NA no up up no no no Axon guidance Autophagy - other 0.41826087 0 0.507850708 kegg kegg NA NA no up up no no no Axon guidance beta-Alanine metabolism -0.723478261 0 0 kegg kegg NA NA no up up no no no Axon guidance Biosynthesis of amino acids -0.411304348 0 0 kegg kegg NA NA no up up no no no Axon guidance Biosynthesis of cofactors -0.471304348 -0.41798419 -0.494723295 kegg kegg NA NA no up up no no no Axon guidance Biosynthesis of unsaturated fatty acids -0.488695652 0 0 kegg kegg NA NA no up up no no no Axon guidance Butanoate metabolism -0.56 0 0 kegg kegg NA NA no up up no no no Axon guidance Calcium signaling pathway 0.683478261 0 0 kegg kegg NA NA no up up no up up Axon guidance cAMP signaling pathway 0.654782609 0 0 yes kegg kegg NA NA no up up no up up Axon guidance Carbon metabolism -0.508695652 0 0 kegg kegg NA NA no up up no no no Axon guidance Cardiac muscle contraction 0.54173913 0 0 kegg kegg NA NA no up up no no up Axon guidance cGMP-PKG signaling pathway 0 0 0.526898327 kegg kegg NA NA no up up no no no Axon guidance Chemokine signaling pathway 0.54173913 0 0 kegg kegg NA NA no up up no no no Axon guidance Citrate cycle (TCA cycle) -0.476521739 0 0 kegg kegg NA NA no up up no no no Axon guidance Drug metabolism - other enzymes -0.524347826 0 0 kegg kegg NA NA no up up no no no Axon guidance Endocytosis 0 0.42687747 0 kegg kegg NA NA no up up no no no Axon guidance ErbB signaling pathway 0.485217391 0 0.420849421 kegg kegg NA NA no up up no no no Axon guidance Fanconi anemia pathway 0 -0.578063241 0 kegg kegg NA NA no up up no no no Axon guidance Fatty acid degradation -0.460869565 0 0 kegg kegg NA NA no up up no no no Axon guidance Fatty acid elongation -0.440869565 0 0 kegg kegg NA NA no up up no no no Axon guidance Fatty acid metabolism -0.48173913 0 0 kegg kegg NA NA no up up no no no Axon guidance Fructose and mannose metabolism -0.690434783 0 0 kegg kegg NA NA no up up no no no Axon guidance Galactose metabolism -0.709565217 0 0 kegg kegg NA NA no up up no no no Axon guidance Glutathione metabolism 0 0 -0.517374517 kegg kegg NA NA no up up no no no Axon guidance Glycerolipid metabolism 0 -0.443675889 0 kegg kegg NA NA no up up no no up Axon guidance Glycerophospholipid metabolism 0 -0.550395257 0 kegg kegg NA NA no up up no no up Axon guidance "Glycine, serine and threonine metabolism" 0 0 -0.433976834 kegg kegg NA NA no up up no up no Axon guidance Glycolysis / Gluconeogenesis -0.562608696 0 0 kegg kegg NA NA no up up no no no Axon guidance Glycosaminoglycan biosynthesis - keratan sulfate 0.454782609 0 0 kegg kegg NA NA no up up no no no Axon guidance Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.661067194 0 kegg kegg NA NA no up up no no no Axon guidance Hedgehog signaling pathway 0 -0.434782609 0 kegg kegg NA NA no up up no no no Axon guidance Histidine metabolism -0.746086957 -0.468379447 0 kegg kegg NA NA no up up no no no Axon guidance Homologous recombination 0 -0.62055336 0 kegg kegg NA NA no up up no no no Axon guidance Inositol phosphate metabolism 0 -0.418972332 0 kegg kegg NA NA no up up no no no Axon guidance Lysosome 0 0.453557312 0 kegg kegg NA NA no up up no no no Axon guidance Mannose type O-glycan biosynthesis 0.473913043 0 0 kegg kegg NA NA no up up no no no Axon guidance mRNA surveillance pathway 0.452173913 0 0 kegg kegg NA NA no up up no no no Axon guidance Non-homologous end-joining -0.514782609 0 0 kegg kegg NA NA no up up no no no Axon guidance Nucleotide excision repair 0 -0.418972332 0 kegg kegg NA NA no up up no no no Axon guidance One carbon pool by folate -0.431304348 -0.46541502 0 kegg kegg NA NA no up up no no no Axon guidance Oocyte meiosis 0 0 0.422908623 kegg kegg NA NA no up up no no no Axon guidance Other types of O-glycan biosynthesis 0 -0.420948617 0 kegg kegg NA NA no up up no no no Axon guidance Oxidative phosphorylation 0.500869565 0 0 kegg kegg NA NA no up up no no no Axon guidance p53 signaling pathway 0 -0.557312253 0 kegg kegg NA NA no up up no no no Axon guidance Phenylalanine metabolism -0.550434783 0 0 kegg kegg NA NA no up up no no no Axon guidance Phosphatidylinositol signaling system 0.535652174 0 0 kegg kegg NA NA no up up no no no Axon guidance Porphyrin and chlorophyll metabolism 0 0 -0.47001287 kegg kegg NA NA no up up no no no Axon guidance PPAR signaling pathway 0 0 0.404890605 kegg kegg NA NA no up up no no no Axon guidance Primary bile acid biosynthesis -0.526956522 0 0 kegg kegg NA NA no up up no no no Axon guidance Pyrimidine metabolism -0.659130435 0 0 kegg kegg NA NA no up up no no no Axon guidance Pyruvate metabolism -0.495652174 0 0 kegg kegg NA NA no up up no no no Axon guidance Ras signaling pathway 0.763478261 0 0 yes kegg kegg NA NA no up up no up up Axon guidance Retinol metabolism -0.553913043 -0.545454545 0 kegg kegg NA NA no up up no no no Axon guidance RNA degradation 0.5 0 0 kegg kegg NA NA no up up no no no Axon guidance Selenocompound metabolism 0 -0.51284585 0 kegg kegg NA NA no up up no no no Axon guidance Sphingolipid signaling pathway 0.653913043 0.727272727 0.463577864 kegg kegg NA NA no up up no no no Axon guidance Starch and sucrose metabolism -0.446086957 0 0 kegg kegg NA NA no up up no no no Axon guidance Steroid hormone biosynthesis -0.523478261 -0.45256917 0 kegg kegg NA NA no up up no no no Axon guidance Sulfur metabolism -0.410434783 0 0 kegg kegg NA NA no up up no no no Axon guidance Synthesis and degradation of ketone bodies -0.423478261 0 0 kegg kegg NA NA no up up no no no Axon guidance TGF-beta signaling pathway 0.569565217 0 0 kegg kegg NA NA no up up no no no Axon guidance Tryptophan metabolism -0.660869565 0 0 kegg kegg NA NA no up up no up no Axon guidance Tyrosine metabolism -0.654782609 0 0 kegg kegg NA NA no up up no no no Axon guidance Ubiquinone and other terpenoid-quinone biosynthesis -0.64173913 -0.447628458 0 kegg kegg NA NA no up up no no no Axon guidance "Valine, leucine and isoleucine degradation" -0.597391304 0 0 kegg kegg NA NA no up up no no no Axon guidance Vascular smooth muscle contraction 0.476521739 0 0 kegg kegg NA NA no up up no no no Axon guidance Viral protein interaction with cytokine and cytokine receptor 0.613043478 0 0 kegg kegg NA NA no up up no no no Axon guidance Wnt signaling pathway 0.537391304 0 0 kegg kegg NA NA no up up no no no B cell receptor signaling pathway 2-Oxocarboxylic acid metabolism 0 -0.533596838 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Adherens junction 0 -0.458498024 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Adrenergic signaling in cardiomyocytes 0 -0.541501976 0 kegg kegg NA NA no no no no no up B cell receptor signaling pathway "Alanine, aspartate and glutamate metabolism" 0 0.653162055 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Aminoacyl-tRNA biosynthesis 0 -0.510869565 -0.406692407 kegg kegg NA NA no no no no no no B cell receptor signaling pathway AMPK signaling pathway -0.453043478 -0.420948617 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Anaerostipes 0 0 -0.425649417 butyrate-producing kegg Genus NA 0.568 no no no no no no B cell receptor signaling pathway Antifolate resistance 0 -0.481225296 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Apelin signaling pathway 0 -0.67687747 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Apoptosis 0 0.87944664 0.474131274 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Arachidonic acid metabolism -0.424347826 0 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Arginine and proline metabolism 0 0.79743083 0.526383526 kegg kegg NA NA no no no no up no B cell receptor signaling pathway Arginine biosynthesis 0 0.62944664 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Autophagy - animal 0 0.760869565 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Basal transcription factors 0 -0.596837945 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Base excision repair 0 -0.552371542 -0.621106821 kegg kegg NA NA no no no no no no B cell receptor signaling pathway beta-Alanine metabolism 0 0 -0.526126126 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Biosynthesis of amino acids 0 0.53458498 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Biosynthesis of cofactors -0.602608696 -0.71541502 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Biosynthesis of unsaturated fatty acids 0 -0.419960474 -0.614671815 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Butanoate metabolism 0 -0.694664032 -0.645817246 kegg kegg NA NA no no no no no no B cell receptor signaling pathway C-type lectin receptor signaling pathway 0.631304348 0.941699605 0.84041184 kegg kegg NA NA no no no no no no B cell receptor signaling pathway cAMP signaling pathway 0 0.645256917 0.505791506 yes kegg kegg NA NA no no no no up up B cell receptor signaling pathway Cardiac muscle contraction 0 -0.580039526 0 kegg kegg NA NA no no no no no up B cell receptor signaling pathway Cell adhesion molecules 0 0.498023715 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Cell cycle 0 -0.705533597 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Cellular senescence 0 0.618577075 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway cGMP-PKG signaling pathway 0.405217391 0.690711462 0.446846847 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Chemokine signaling pathway 0 0.705533597 0.457657658 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Citrate cycle (TCA cycle) 0 -0.714426877 -0.456113256 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Complement and coagulation cascades 0 0.538537549 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Cysteine and methionine metabolism -0.620869565 -0.738142292 -0.727155727 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Cytosolic DNA-sensing pathway 0 0.619565217 0.540540541 kegg kegg NA NA no no no no no no B cell receptor signaling pathway DNA replication 0 -0.825098814 -0.481081081 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Drug metabolism - cytochrome P450 -0.528695652 -0.7756917 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Drug metabolism - other enzymes -0.439130435 -0.673913043 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway ECM-receptor interaction -0.453913043 -0.47826087 0 kegg kegg NA NA no no no no up up B cell receptor signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.532608696 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Endocytosis 0 0.516798419 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway ErbB signaling pathway 0.49826087 0.468379447 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Ether lipid metabolism 0 -0.489130435 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Fanconi anemia pathway 0 -0.530632411 -0.53024453 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Fatty acid biosynthesis 0 0.675889328 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Fatty acid elongation 0 0 -0.605405405 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Focal adhesion 0 -0.492094862 0 kegg kegg NA NA no no no no up up B cell receptor signaling pathway FoxO signaling pathway 0 0 -0.466666667 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Galactose metabolism 0 0.46541502 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Gap junction -0.48173913 0 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Glutathione metabolism -0.463478261 -0.691699605 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Glycerolipid metabolism 0.483478261 0 0 kegg kegg NA NA no no no no no up B cell receptor signaling pathway "Glycine, serine and threonine metabolism" -0.532173913 -0.595849802 0 kegg kegg NA NA no no no no up no B cell receptor signaling pathway Glycolysis / Gluconeogenesis -0.55826087 -0.519762846 -0.403088803 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.720355731 0.46975547 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Glycosaminoglycan degradation 0 0.499011858 0 kegg kegg NA NA no no no no no up B cell receptor signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 -0.489130435 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.692173913 0.504940711 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.652173913 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Hedgehog signaling pathway 0 -0.490118577 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway HIF-1 signaling pathway 0 -0.530632411 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Hippo signaling pathway 0 -0.549407115 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Hippo signaling pathway - multiple species 0.713043478 0.716403162 0.457657658 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Homologous recombination 0 0 -0.593050193 kegg kegg NA NA no no no no no no B cell receptor signaling pathway IL-17 signaling pathway 0.52173913 0.692687747 0.544916345 kegg kegg NA NA no no no no no no B cell receptor signaling pathway JAK-STAT signaling pathway 0 0.600790514 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Longevity regulating pathway - multiple species 0 0 -0.603861004 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Lysosome 0.555652174 0.564229249 0.498326898 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Mannose type O-glycan biosynthesis 0.49826087 0 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Metabolism of xenobiotics by cytochrome P450 -0.548695652 -0.717391304 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Mismatch repair 0 -0.781620553 -0.646846847 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Mitophagy - animal 0 -0.433794466 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway mRNA surveillance pathway 0 -0.482213439 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway mTOR signaling pathway 0 -0.516798419 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Mucin type O-glycan biosynthesis -0.405217391 0 -0.430888031 kegg kegg NA NA no no no no no no B cell receptor signaling pathway N-Glycan biosynthesis 0 -0.706521739 -0.458944659 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Natural killer cell mediated cytotoxicity 0 0.543478261 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Neuroactive ligand-receptor interaction 0 0.437747036 0 kegg kegg NA NA no no no up up up B cell receptor signaling pathway Neutrophil extracellular trap formation 0 0.498023715 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway NF-kappa B signaling pathway 0.614782609 0.85770751 0.665122265 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Nicotinate and nicotinamide metabolism 0 0.706521739 0.401287001 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Nitrogen metabolism 0 0.595849802 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway NOD-like receptor signaling pathway 0 0.837944664 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Non-homologous end-joining -0.451304348 -0.529644269 -0.733333333 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Notch signaling pathway 0.68 0 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Nucleotide excision repair 0 -0.82312253 -0.694465894 kegg kegg NA NA no no no no no no B cell receptor signaling pathway One carbon pool by folate -0.405217391 -0.808300395 -0.451480051 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Oocyte meiosis 0 -0.649209486 -0.431145431 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Osteoclast differentiation 0.531304348 0.82312253 0.654826255 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Oxidative phosphorylation 0 -0.602766798 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Pantothenate and CoA biosynthesis 0 0.596837945 0 kegg kegg NA NA no no no no no dn B cell receptor signaling pathway Pentose and glucuronate interconversions -0.491304348 -0.68972332 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Pentose phosphate pathway 0 0.558300395 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Peroxisome 0 0.489130435 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Phagosome 0 0.513833992 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Phenylalanine metabolism -0.463478261 -0.616600791 -0.416988417 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Phosphatidylinositol signaling system 0 -0.451581028 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Phospholipase D signaling pathway 0 0.643280632 0 kegg kegg NA NA no no no no up up B cell receptor signaling pathway Platinum drug resistance 0 0 -0.413642214 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Porphyrin and chlorophyll metabolism -0.59826087 -0.509881423 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway PPAR signaling pathway 0 0.739130435 0.500643501 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Prevotella -0.5388413 0 0 acetate-producing kegg Genus NA 0.287 no no no no no no B cell receptor signaling pathway Primary bile acid biosynthesis 0 -0.467391304 -0.419047619 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Propanoate metabolism -0.590434783 -0.697628458 -0.703989704 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Proteasome 0 -0.602766798 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Protein export 0 -0.636363636 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Protein processing in endoplasmic reticulum -0.433043478 -0.698616601 -0.477734878 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Purine metabolism -0.486956522 -0.5256917 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Pyrimidine metabolism 0 -0.760869565 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Pyruvate metabolism -0.557391304 -0.785573123 -0.739253539 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Ras signaling pathway 0 -0.599802372 0 yes kegg kegg NA NA no no no no up up B cell receptor signaling pathway Renin-angiotensin system 0 0.631422925 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Retinol metabolism -0.504347826 -0.649209486 -0.440669241 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Ribosome 0 -0.604743083 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Ribosome biogenesis in eukaryotes 0 -0.695652174 -0.413642214 kegg kegg NA NA no no no no no no B cell receptor signaling pathway RIG-I-like receptor signaling pathway 0.508695652 0.840909091 0.681338481 kegg kegg NA NA no no no no no no B cell receptor signaling pathway RNA degradation 0 -0.572134387 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway RNA polymerase 0 -0.738142292 -0.430630631 kegg kegg NA NA no no no no no no B cell receptor signaling pathway RNA transport 0 -0.437747036 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Sarcina 0 0.466781936 0 kegg Genus NA 0.0703 no no no no no no B cell receptor signaling pathway SNARE interactions in vesicular transport 0 0.567193676 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Sphingolipid metabolism 0.444347826 0 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Sphingolipid signaling pathway 0 0.634387352 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Starch and sucrose metabolism 0 0.601778656 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Steroid biosynthesis 0 -0.740118577 -0.64993565 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Steroid hormone biosynthesis 0 -0.583992095 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Sulfur metabolism 0 -0.484189723 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Synthesis and degradation of ketone bodies 0 -0.781620553 -0.637323037 kegg kegg NA NA no no no no no no B cell receptor signaling pathway T cell receptor signaling pathway 0 0.518774704 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Terpenoid backbone biosynthesis 0 -0.485177866 -0.400514801 kegg kegg NA NA no no no no no no B cell receptor signaling pathway TGF-beta signaling pathway 0 -0.542490119 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Th1 and Th2 cell differentiation 0.562608696 0.592885375 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Th17 cell differentiation 0.549565217 0.615612648 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Thiamine metabolism 0 -0.559288538 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Tight junction 0 -0.45256917 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Toll-like receptor signaling pathway 0.490434783 0.933794466 0.782754183 yes kegg kegg NA NA no no no no no no B cell receptor signaling pathway Tryptophan metabolism 0 -0.538537549 -0.412097812 kegg kegg NA NA no no no no up no B cell receptor signaling pathway Tyrosine metabolism -0.65826087 -0.785573123 -0.726898327 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.675889328 -0.573230373 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Ubiquitin mediated proteolysis 0 -0.554347826 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway "Valine, leucine and isoleucine degradation" 0 -0.690711462 -0.626512227 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Various types of N-glycan biosynthesis 0 -0.576086957 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Vascular smooth muscle contraction 0 -0.632411067 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway VEGF signaling pathway 0.549565217 0.579051383 0 kegg kegg NA NA no no no no no no B cell receptor signaling pathway Wnt signaling pathway 0 -0.630434783 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells 2-Oxocarboxylic acid metabolism 0.42173913 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells ABC transporters 0 -0.696640316 0 kegg kegg NA NA no no no no up up Bacterial invasion of epithelial cells Adherens junction 0.906956522 0.922924901 0.912998713 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Adipocytokine signaling pathway 0 -0.601778656 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells AGE-RAGE signaling pathway in diabetic complications 0 -0.414031621 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells "Alanine, aspartate and glutamate metabolism" 0 -0.508893281 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells alpha-Linolenic acid metabolism 0.405217391 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Amyotrophic lateral sclerosis 0 0 0.462290862 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Antigen processing and presentation 0 0.415019763 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Apoptosis 0.623478261 0 0.48030888 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Apoptosis - multiple species -0.665217391 -0.68972332 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Arginine biosynthesis 0 -0.436758893 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Ascorbate and aldarate metabolism 0 0.447628458 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Autophagy - animal -0.691304348 -0.75 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Autophagy - other -0.829565217 -0.796442688 -0.475160875 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Basal transcription factors -0.717391304 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Base excision repair -0.546086957 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells beta-Alanine metabolism 0.482608696 0.520750988 0.418018018 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Bifidobacterium 0 0.473998482 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Bacterial invasion of epithelial cells Biosynthesis of amino acids 0.466956522 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Biosynthesis of unsaturated fatty acids 0 0 0.434234234 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells C-type lectin receptor signaling pathway -0.428695652 0 -0.517889318 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Carbohydrate digestion and absorption -0.540869565 -0.475296443 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Carbon metabolism 0.537391304 0.683794466 0.443758044 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Cardiac muscle contraction 0 0.423913043 0 kegg kegg NA NA no no no no no up Bacterial invasion of epithelial cells Cell adhesion molecules 0.455652174 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Cell cycle -0.406956522 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Cholesterol metabolism 0 0.416007905 0 yes kegg kegg NA NA no no no no no up Bacterial invasion of epithelial cells Cholinergic synapse -0.427826087 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Circadian entrainment 0 0.494071146 0 kegg kegg NA NA no no no no up up Bacterial invasion of epithelial cells Circadian rhythm -0.665217391 0 -0.440926641 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Citrate cycle (TCA cycle) 0 0.434782609 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Clostridium 0 0.522647208 0 kegg Genus NA 0.925 no no no no no no Bacterial invasion of epithelial cells Complement and coagulation cascades 0 0 0.488803089 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Cytokine-cytokine receptor interaction 0 0 0.675160875 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Drug metabolism - cytochrome P450 0 0.527667984 0.403861004 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Drug metabolism - other enzymes 0 0.669960474 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells EGFR tyrosine kinase inhibitor resistance -0.45826087 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells ErbB signaling pathway -0.47826087 -0.596837945 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Fatty acid biosynthesis 0 -0.414031621 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Fatty acid elongation 0.500869565 0.51284585 0.446589447 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Focal adhesion 0.885217391 0.946640316 0.9003861 kegg kegg NA NA no no no no up up Bacterial invasion of epithelial cells FoxO signaling pathway -0.449565217 -0.707509881 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Fructose and mannose metabolism 0.405217391 -0.423913043 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Galactose metabolism 0.512173913 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Gastric acid secretion 0.802608696 0.822134387 0.810553411 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Glycerolipid metabolism 0 -0.654150198 0 kegg kegg NA NA no no no no no up Bacterial invasion of epithelial cells Glycerophospholipid metabolism -0.513913043 -0.752964427 0 kegg kegg NA NA no no no no no up Bacterial invasion of epithelial cells Glycolysis / Gluconeogenesis 0 0.62944664 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.574110672 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.610434783 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.511857708 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Glyoxylate and dicarboxylate metabolism 0 -0.416996047 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells GnRH secretion -0.519130435 -0.616600791 0 kegg kegg NA NA no no no no up up Bacterial invasion of epithelial cells "Growth hormone synthesis, secretion and action" 0 -0.584980237 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Hematopoietic cell lineage 0 0.570158103 0.507850708 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells HIF-1 signaling pathway -0.48173913 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Hippo signaling pathway 0.824347826 0.855731225 0.876447876 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Homologous recombination 0 -0.62055336 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Huntington disease 0 0 0.415444015 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Inositol phosphate metabolism 0 -0.646245059 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Insulin resistance -0.667826087 -0.633399209 -0.686743887 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Insulin signaling pathway -0.486086957 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Intestinal immune network for IgA production 0 0.515810277 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells JAK-STAT signaling pathway 0 -0.713438735 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Lachnospira 0 0.619718329 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Bacterial invasion of epithelial cells Leukocyte transendothelial migration 0.777391304 0.833992095 0.820849421 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Long-term potentiation -0.505217391 0 0 kegg kegg NA NA no no no no no up Bacterial invasion of epithelial cells Longevity regulating pathway -0.473043478 -0.672924901 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Lysine degradation -0.480869565 -0.515810277 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells MAPK signaling pathway 0 -0.581027668 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Metabolism of xenobiotics by cytochrome P450 0 0.613636364 0.482625483 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells mRNA surveillance pathway -0.540869565 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells mTOR signaling pathway -0.426086957 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Mucin type O-glycan biosynthesis 0 -0.56916996 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Natural killer cell mediated cytotoxicity 0.452173913 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Neutrophil extracellular trap formation 0.562608696 0 0.467953668 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells NF-kappa B signaling pathway 0 -0.621541502 -0.648391248 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Nicotine addiction 0 -0.565217391 0 kegg kegg NA NA no no no no up up Bacterial invasion of epithelial cells Nitrogen metabolism 0 -0.476284585 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells NOD-like receptor signaling pathway 0 -0.458498024 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Non-homologous end-joining 0 0.428853755 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Notch signaling pathway 0 -0.46541502 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Oocyte meiosis -0.430434783 0.429841897 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Other glycan degradation 0 -0.467391304 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Other types of O-glycan biosynthesis -0.587826087 -0.616600791 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Oxidative phosphorylation 0 0.441699605 0.423938224 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Oxytocin signaling pathway 0.848695652 0.811264822 0.671557272 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells p53 signaling pathway -0.791304348 -0.804347826 -0.503217503 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Pentose phosphate pathway 0.56 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Phagosome 0.546956522 0 0.457400257 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Phenylalanine metabolism 0.646086957 0.59486166 0.55032175 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Phosphatidylinositol signaling system -0.53826087 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Phospholipase D signaling pathway 0 -0.440711462 0 kegg kegg NA NA no no no no up up Bacterial invasion of epithelial cells Phototransduction 0 0.668972332 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Platelet activation 0.866956522 0.90513834 0.831402831 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Platinum drug resistance -0.726086957 -0.659090909 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Prevotella 0 -0.416691439 0 acetate-producing kegg Genus NA 0.287 no no no no no no Bacterial invasion of epithelial cells Primary bile acid biosynthesis 0 0.423913043 0.429343629 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Prion disease 0 0.480237154 0.520978121 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Progesterone-mediated oocyte maturation -0.569565217 -0.641304348 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Proteasome 0 0.572134387 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Protein export -0.602608696 0.457509881 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Pyrimidine metabolism 0 0 -0.402574003 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Rap1 signaling pathway 0.805217391 0.855731225 0.791248391 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Ras signaling pathway 0 0.448616601 0 yes kegg kegg NA NA no no no no up up Bacterial invasion of epithelial cells Regulation of actin cytoskeleton 0.710434783 0.746047431 0.775032175 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Renin secretion 0 0.447628458 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Retrograde endocannabinoid signaling 0 0.496047431 0 kegg kegg NA NA no no no no no up Bacterial invasion of epithelial cells Ribosome -0.432173913 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Ribosome biogenesis in eukaryotes -0.568695652 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells RIG-I-like receptor signaling pathway -0.463478261 -0.627470356 -0.616473616 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells RNA degradation -0.502608696 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells RNA polymerase -0.743478261 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Salivary secretion 0 0.53458498 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Selenocompound metabolism -0.62 -0.546442688 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Signaling pathways regulating pluripotency of stem cells -0.503478261 -0.57312253 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells SNARE interactions in vesicular transport 0 -0.601778656 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Sphingolipid metabolism 0.413043478 0.444664032 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Spinocerebellar ataxia -0.809565217 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Spliceosome -0.710434783 -0.712450593 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Sulfur metabolism 0.426086957 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells T cell receptor signaling pathway 0 -0.670948617 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Taurine and hypotaurine metabolism -0.488695652 -0.757905138 -0.405662806 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Terpenoid backbone biosynthesis -0.440869565 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells TGF-beta signaling pathway 0 0.470355731 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Thermogenesis 0 0.438735178 0.408751609 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Thiamine metabolism 0 0 -0.47953668 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Thyroid hormone signaling pathway 0.760869565 0.776679842 0.724324324 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Tight junction 0.907826087 0.937747036 0.769111969 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells TNF signaling pathway -0.459130435 -0.513833992 -0.400772201 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Tryptophan metabolism 0 0.499011858 0 kegg kegg NA NA no no no no up no Bacterial invasion of epithelial cells Type II diabetes mellitus -0.489565217 -0.666007905 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Various types of N-glycan biosynthesis -0.431304348 0 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Vascular smooth muscle contraction 0 0.517786561 0 kegg kegg NA NA no no no no no no Bacterial invasion of epithelial cells Viral protein interaction with cytokine and cytokine receptor 0 0 0.509395109 kegg kegg NA NA no no no no no no Bacteroides Eggerthella 0.488630222 0 0 LPS-producing Genus Genus 0.000267 0.912 dn dn up no no no Basal cell carcinoma Adrenergic signaling in cardiomyocytes 0 0.470355731 0 kegg kegg NA NA no no no no no up Basal cell carcinoma "Alanine, aspartate and glutamate metabolism" -0.406956522 -0.419960474 -0.524066924 kegg kegg NA NA no no no no no no Basal cell carcinoma Alcoholism 0 -0.543478261 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Aldosterone synthesis and secretion 0.480869565 0.504940711 0 kegg kegg NA NA no no no no up up Basal cell carcinoma alpha-Linolenic acid metabolism 0 -0.454545455 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Alzheimer disease 0.452173913 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Amino sugar and nucleotide sugar metabolism -0.54 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Amoebiasis 0 0 -0.54002574 kegg kegg NA NA no no no no no no Basal cell carcinoma AMPK signaling pathway 0 0.427865613 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Amyotrophic lateral sclerosis 0.533913043 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Antigen processing and presentation -0.504347826 0 -0.482625483 kegg kegg NA NA no no no no no no Basal cell carcinoma Apelin signaling pathway 0.406956522 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Apoptosis 0 0 -0.411583012 kegg kegg NA NA no no no no no no Basal cell carcinoma Arachidonic acid metabolism 0 -0.423913043 -0.596911197 kegg kegg NA NA no no no no no no Basal cell carcinoma Arginine and proline metabolism -0.556521739 -0.437747036 0 kegg kegg NA NA no no no no up no Basal cell carcinoma Arginine biosynthesis -0.46 -0.489130435 -0.598455598 kegg kegg NA NA no no no no no no Basal cell carcinoma Autophagy - other 0 0.508893281 0.706821107 kegg kegg NA NA no no no no no no Basal cell carcinoma Bacterial invasion of epithelial cells 0 0 -0.465894466 kegg kegg NA NA no no no no no no Basal cell carcinoma Basal transcription factors 0 0.429841897 0.52020592 kegg kegg NA NA no no no no no no Basal cell carcinoma Base excision repair 0 0.453557312 0 kegg kegg NA NA no no no no no no Basal cell carcinoma beta-Alanine metabolism -0.41826087 0 -0.496525097 kegg kegg NA NA no no no no no no Basal cell carcinoma Biosynthesis of amino acids -0.556521739 -0.656126482 -0.760875161 kegg kegg NA NA no no no no no no Basal cell carcinoma Biosynthesis of unsaturated fatty acids -0.504347826 -0.552371542 -0.450965251 kegg kegg NA NA no no no no no no Basal cell carcinoma Calcium signaling pathway 0.517391304 0.537549407 0.578635779 kegg kegg NA NA no no no no up up Basal cell carcinoma Carbohydrate digestion and absorption 0 0 0.444272844 kegg kegg NA NA no no no no no no Basal cell carcinoma Carbon metabolism -0.496521739 -0.548418972 -0.719433719 kegg kegg NA NA no no no no no no Basal cell carcinoma Cardiac muscle contraction 0.468695652 0 0 kegg kegg NA NA no no no no no up Basal cell carcinoma Cell cycle 0 0.563241107 0.643500644 kegg kegg NA NA no no no no no no Basal cell carcinoma cGMP-PKG signaling pathway 0 -0.650197628 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Chemical carcinogenesis - DNA adducts -0.78 -0.764822134 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Chemical carcinogenesis - receptor activation 0 0.538537549 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Cholinergic synapse 0 0 0.512998713 kegg kegg NA NA no no no no no no Basal cell carcinoma Circadian rhythm 0.446956522 0.787549407 0.86975547 kegg kegg NA NA no no no no no no Basal cell carcinoma Cocaine addiction 0.471304348 0.450592885 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Collecting duct acid secretion 0 -0.782608696 -0.63989704 kegg kegg NA NA no no no no no no Basal cell carcinoma Colorectal cancer 0.685217391 0.687747036 0.693178893 kegg kegg NA NA no no no no no no Basal cell carcinoma Complement and coagulation cascades -0.491304348 -0.660079051 -0.737966538 kegg kegg NA NA no no no no no no Basal cell carcinoma Coronavirus disease - COVID-19 0.66 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Cortisol synthesis and secretion 0.437391304 0.471343874 0 kegg kegg NA NA no no no no no up Basal cell carcinoma Cushing syndrome 0.622608696 0.612648221 0.546718147 kegg kegg NA NA no no no no no up Basal cell carcinoma Cytokine-cytokine receptor interaction 0 -0.663043478 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Drug metabolism - cytochrome P450 -0.446956522 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Drug metabolism - other enzymes -0.484347826 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma EGFR tyrosine kinase inhibitor resistance 0.571304348 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Endocrine resistance 0.416521739 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Endometrial cancer 0.58 0 0.742084942 kegg kegg NA NA no no no no no no Basal cell carcinoma ErbB signaling pathway 0.49826087 0.471343874 0.633462033 kegg kegg NA NA no no no no no no Basal cell carcinoma Ether lipid metabolism 0.545217391 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Fanconi anemia pathway 0 0 0.406692407 kegg kegg NA NA no no no no no no Basal cell carcinoma Fat digestion and absorption -0.603478261 -0.750988142 0 yes kegg kegg NA NA no no no no up up Basal cell carcinoma Fatty acid biosynthesis -0.460869565 -0.440711462 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Fatty acid degradation -0.495652174 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Fatty acid elongation -0.47826087 -0.4743083 -0.477477477 kegg kegg NA NA no no no no no no Basal cell carcinoma Fatty acid metabolism -0.603478261 -0.593873518 -0.451222651 kegg kegg NA NA no no no no no no Basal cell carcinoma Fc gamma R-mediated phagocytosis -0.570434783 -0.695652174 -0.747490347 kegg kegg NA NA no no no no no no Basal cell carcinoma Folate biosynthesis 0 0.623517787 0 kegg kegg NA NA no no no no no no Basal cell carcinoma GABAergic synapse -0.483478261 -0.494071146 -0.436808237 kegg kegg NA NA no no no no up up Basal cell carcinoma Galactose metabolism -0.412173913 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Glioma 0 0 0.499099099 kegg kegg NA NA no no no no no no Basal cell carcinoma Glucagon signaling pathway 0 0.459486166 0.525868726 kegg kegg NA NA no no no no no no Basal cell carcinoma Glutathione metabolism 0 0 -0.503989704 kegg kegg NA NA no no no no no no Basal cell carcinoma Glycerolipid metabolism 0 0 0.641184041 kegg kegg NA NA no no no no no up Basal cell carcinoma Glycerophospholipid metabolism 0 0 0.64993565 kegg kegg NA NA no no no no no up Basal cell carcinoma Glycolysis / Gluconeogenesis -0.468695652 0 -0.525868726 kegg kegg NA NA no no no no no no Basal cell carcinoma Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.505928854 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Glycosaminoglycan biosynthesis - keratan sulfate 0.684347826 0.811264822 0.52046332 kegg kegg NA NA no no no no no no Basal cell carcinoma Glycosphingolipid biosynthesis - lacto and neolacto series 0.528695652 0 0.524839125 kegg kegg NA NA no no no no no no Basal cell carcinoma Glyoxylate and dicarboxylate metabolism -0.46173913 -0.497035573 -0.580952381 kegg kegg NA NA no no no no no no Basal cell carcinoma GnRH secretion 0.492173913 0.467391304 0.619047619 kegg kegg NA NA no no no no up up Basal cell carcinoma GnRH signaling pathway 0 0.419960474 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Hedgehog signaling pathway 0.593913043 0.545454545 0.82007722 kegg kegg NA NA no no no no no no Basal cell carcinoma Hepatitis B 0 0 0.544916345 kegg kegg NA NA no no no no no no Basal cell carcinoma Hepatitis C 0 0 0.537709138 kegg kegg NA NA no no no no no no Basal cell carcinoma Herpes simplex virus 1 infection -0.429565217 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Human T-cell leukemia virus 1 infection -0.415652174 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Huntington disease 0.483478261 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma IL-17 signaling pathway 0 -0.59486166 -0.406692407 kegg kegg NA NA no no no no no no Basal cell carcinoma Inositol phosphate metabolism 0 0 0.508880309 kegg kegg NA NA no no no no no no Basal cell carcinoma Insulin resistance 0.449565217 0 0.775546976 kegg kegg NA NA no no no no no no Basal cell carcinoma Insulin secretion 0.545217391 0.568181818 0 yes kegg kegg NA NA no no no no up up Basal cell carcinoma Insulin signaling pathway 0.468695652 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Kaposi sarcoma-associated herpesvirus infection 0.410434783 0 0 kegg kegg NA NA no no no no no dn Basal cell carcinoma Leishmaniasis 0 0 -0.43037323 kegg kegg NA NA no no no no no no Basal cell carcinoma Leukocyte transendothelial migration 0 0 -0.574002574 kegg kegg NA NA no no no no no no Basal cell carcinoma Long-term potentiation 0 0 0.533333333 kegg kegg NA NA no no no no no up Basal cell carcinoma Longevity regulating pathway 0.416521739 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Longevity regulating pathway - multiple species 0 -0.466403162 -0.46048906 kegg kegg NA NA no no no no no no Basal cell carcinoma Lysine degradation 0.626086957 0.789525692 0.788416988 kegg kegg NA NA no no no no no no Basal cell carcinoma Lysosome 0 -0.589920949 -0.458944659 kegg kegg NA NA no no no no no no Basal cell carcinoma Mannose type O-glycan biosynthesis 0.846956522 0.875494071 0.803603604 kegg kegg NA NA no no no no no no Basal cell carcinoma MAPK signaling pathway 0 0 0.413127413 kegg kegg NA NA no no no no no no Basal cell carcinoma Maturity onset diabetes of the young 0 0 0.419305019 kegg kegg NA NA no no no no up no Basal cell carcinoma Melanogenesis 0.435652174 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Metabolism of xenobiotics by cytochrome P450 -0.50173913 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma MicroRNAs in cancer 0 0 0.686229086 kegg kegg NA NA no no no no no no Basal cell carcinoma Mitophagy - animal 0.443478261 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma mRNA surveillance pathway 0.58 0.805335968 0.842471042 kegg kegg NA NA no no no no no no Basal cell carcinoma mTOR signaling pathway 0.54173913 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma N-Glycan biosynthesis 0.406086957 0.549407115 0.501930502 kegg kegg NA NA no no no no no no Basal cell carcinoma Necroptosis 0 0 -0.407207207 kegg kegg NA NA no no no no no no Basal cell carcinoma Neuroactive ligand-receptor interaction -0.507826087 -0.677865613 -0.614929215 kegg kegg NA NA no no no up up up Basal cell carcinoma Neurotrophin signaling pathway 0.430434783 0 0.496782497 kegg kegg NA NA no no no no no no Basal cell carcinoma Neutrophil extracellular trap formation -0.523478261 -0.72826087 -0.738996139 kegg kegg NA NA no no no no no no Basal cell carcinoma NF-kappa B signaling pathway 0 0 0.412355212 kegg kegg NA NA no no no no no no Basal cell carcinoma Nicotinate and nicotinamide metabolism -0.496521739 -0.456521739 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Nicotine addiction 0 0.476284585 0.421621622 kegg kegg NA NA no no no no up up Basal cell carcinoma Nitrogen metabolism 0 -0.484189723 -0.470527671 kegg kegg NA NA no no no no no no Basal cell carcinoma NOD-like receptor signaling pathway -0.511304348 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Non-alcoholic fatty liver disease 0.491304348 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Non-homologous end-joining 0 0 -0.431402831 kegg kegg NA NA no no no no no no Basal cell carcinoma Notch signaling pathway 0 0.443675889 0.62960103 kegg kegg NA NA no no no no no no Basal cell carcinoma Olfactory transduction -0.509565217 -0.847826087 -0.594079794 kegg kegg NA NA no no no no no no Basal cell carcinoma One carbon pool by folate 0 0 0.422136422 kegg kegg NA NA no no no no no no Basal cell carcinoma Osteoclast differentiation 0 -0.41798419 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Other types of O-glycan biosynthesis 0.560869565 0.645256917 0.684169884 kegg kegg NA NA no no no no no no Basal cell carcinoma Oxidative phosphorylation 0.445217391 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Oxytocin signaling pathway 0 -0.488142292 -0.730501931 kegg kegg NA NA no no no no no no Basal cell carcinoma p53 signaling pathway 0 0 0.475418275 kegg kegg NA NA no no no no no no Basal cell carcinoma Pancreatic cancer 0 0.539525692 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Pantothenate and CoA biosynthesis -0.474782609 -0.572134387 -0.477992278 kegg kegg NA NA no no no no no dn Basal cell carcinoma "Parathyroid hormone synthesis, secretion and action" 0.453913043 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Parkinson disease 0.506956522 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Pathogenic Escherichia coli infection -0.437391304 -0.531620553 -0.580952381 kegg kegg NA NA no no no no no no Basal cell carcinoma Pathways in cancer 0.440869565 0 0.568082368 kegg kegg NA NA no no no no no no Basal cell carcinoma Pathways of neurodegeneration - multiple diseases 0.516521739 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Pentose phosphate pathway 0 -0.684782609 -0.663835264 kegg kegg NA NA no no no no no no Basal cell carcinoma Peroxisome -0.533043478 -0.559288538 -0.605405405 kegg kegg NA NA no no no no no no Basal cell carcinoma Pertussis -0.739130435 -0.650197628 -0.672329472 kegg kegg NA NA no no no no no dn Basal cell carcinoma Phagosome 0 -0.460474308 -0.493951094 kegg kegg NA NA no no no no no no Basal cell carcinoma Phosphatidylinositol signaling system 0.509565217 0.43972332 0.737451737 kegg kegg NA NA no no no no no no Basal cell carcinoma Platelet activation 0 0 -0.421106821 kegg kegg NA NA no no no no no no Basal cell carcinoma Platinum drug resistance 0 0.461462451 0 kegg kegg NA NA no no no no no no Basal cell carcinoma PPAR signaling pathway -0.440869565 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Primary bile acid biosynthesis 0 -0.518774704 -0.631402831 kegg kegg NA NA no no no no no no Basal cell carcinoma Progesterone-mediated oocyte maturation 0 0.484189723 0.599227799 kegg kegg NA NA no no no no no no Basal cell carcinoma Prostate cancer 0.486086957 0 0.658172458 kegg kegg NA NA no no no no no no Basal cell carcinoma Protein export 0 0 0.536164736 kegg kegg NA NA no no no no no no Basal cell carcinoma Protein processing in endoplasmic reticulum 0 0.51284585 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Proteoglycans in cancer 0.440869565 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Pyrimidine metabolism -0.528695652 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Ras signaling pathway 0 0 0.559330759 yes kegg kegg NA NA no no no no up up Basal cell carcinoma Regulation of actin cytoskeleton 0 -0.438735178 -0.447619048 kegg kegg NA NA no no no no no no Basal cell carcinoma Renal cell carcinoma 0.413913043 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Renin-angiotensin system -0.466956522 -0.53458498 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Retinol metabolism -0.595652174 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Ribosome 0.663478261 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Ribosome biogenesis in eukaryotes 0 0.494071146 0.597940798 kegg kegg NA NA no no no no no no Basal cell carcinoma RIG-I-like receptor signaling pathway 0 0 0.425225225 kegg kegg NA NA no no no no no no Basal cell carcinoma RNA degradation 0.590434783 0.670948617 0.784041184 kegg kegg NA NA no no no no no no Basal cell carcinoma RNA polymerase 0 0.530632411 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Salmonella infection -0.548695652 -0.551383399 -0.607464607 kegg kegg NA NA no no no no no no Basal cell carcinoma Selenocompound metabolism 0 0 0.437580438 kegg kegg NA NA no no no no no no Basal cell carcinoma Serotonergic synapse 0 0 -0.46023166 kegg kegg NA NA no no no no no no Basal cell carcinoma Signaling pathways regulating pluripotency of stem cells 0.683478261 0.822134387 0.751608752 kegg kegg NA NA no no no no no no Basal cell carcinoma SNARE interactions in vesicular transport 0 0 0.426769627 kegg kegg NA NA no no no no no no Basal cell carcinoma Spinocerebellar ataxia 0 0.744071146 0.605405405 kegg kegg NA NA no no no no no no Basal cell carcinoma Spliceosome 0 0.610671937 0.644272844 kegg kegg NA NA no no no no no no Basal cell carcinoma Staphylococcus aureus infection -0.508695652 -0.597826087 -0.810553411 kegg kegg NA NA no no no up no no Basal cell carcinoma Starch and sucrose metabolism -0.46173913 -0.466403162 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Steroid hormone biosynthesis -0.555652174 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Sulfur metabolism 0 0 -0.548262548 kegg kegg NA NA no no no no no no Basal cell carcinoma Synaptic vesicle cycle 0 -0.802371542 -0.420592021 kegg kegg NA NA no no no no up up Basal cell carcinoma T cell receptor signaling pathway 0 0 0.45019305 kegg kegg NA NA no no no no no no Basal cell carcinoma Taste transduction 0 0 0.65019305 kegg kegg NA NA no no no no no up Basal cell carcinoma Taurine and hypotaurine metabolism 0 0.437747036 0.708622909 kegg kegg NA NA no no no no no no Basal cell carcinoma TGF-beta signaling pathway 0.486956522 0 0.453024453 kegg kegg NA NA no no no no no no Basal cell carcinoma Thermogenesis 0.556521739 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Tight junction 0 0 -0.748005148 kegg kegg NA NA no no no no no no Basal cell carcinoma Toxoplasmosis -0.476521739 0 -0.408751609 kegg kegg NA NA no no no no no no Basal cell carcinoma Transcriptional misregulation in cancer 0 0 0.52046332 kegg kegg NA NA no no no no no no Basal cell carcinoma Tuberculosis -0.496521739 -0.635375494 -0.727670528 kegg kegg NA NA no no no no no dn Basal cell carcinoma Tyrosine metabolism 0 0 -0.462033462 kegg kegg NA NA no no no no no no Basal cell carcinoma Ubiquitin mediated proteolysis 0.525217391 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Various types of N-glycan biosynthesis 0 0.567193676 0.439124839 kegg kegg NA NA no no no no no no Basal cell carcinoma VEGF signaling pathway 0 0 0.471299871 kegg kegg NA NA no no no no no no Basal cell carcinoma Viral protein interaction with cytokine and cytokine receptor 0 -0.681818182 -0.451994852 kegg kegg NA NA no no no no no no Basal cell carcinoma Vitamin digestion and absorption 0.413913043 0 0 kegg kegg NA NA no no no no no no Basal cell carcinoma Wnt signaling pathway 0.759130435 0.660079051 0.783783784 kegg kegg NA NA no no no no no no Basal cell carcinoma Yersinia infection 0 -0.580039526 -0.401287001 kegg kegg NA NA no no no no no no Basal transcription factors Aminoacyl-tRNA biosynthesis 0 0.649209486 0.592020592 kegg kegg NA NA no no no no no no Basal transcription factors Antifolate resistance 0 0.433794466 0.440926641 kegg kegg NA NA no no no no no no Basal transcription factors Arachidonic acid metabolism 0 0 -0.531274131 kegg kegg NA NA no no no no no no Basal transcription factors Arginine and proline metabolism 0 -0.488142292 -0.403861004 kegg kegg NA NA no no no no up no Basal transcription factors Arginine biosynthesis 0 0 -0.454568855 kegg kegg NA NA no no no no no no Basal transcription factors Ascorbate and aldarate metabolism 0 0 0.557014157 kegg kegg NA NA no no no no no no Basal transcription factors Biosynthesis of amino acids -0.49826087 -0.643280632 -0.67953668 kegg kegg NA NA no no no no no no Basal transcription factors Biosynthesis of cofactors 0 0.612648221 0 kegg kegg NA NA no no no no no no Basal transcription factors Butanoate metabolism 0 0.488142292 0.489317889 kegg kegg NA NA no no no no no no Basal transcription factors Carbon metabolism 0 0 -0.409009009 kegg kegg NA NA no no no no no no Basal transcription factors Citrate cycle (TCA cycle) 0 0.502964427 0.645045045 kegg kegg NA NA no no no no no no Basal transcription factors Cysteine and methionine metabolism 0 0.497035573 0.6 kegg kegg NA NA no no no no no no Basal transcription factors EGFR tyrosine kinase inhibitor resistance 0.555652174 0 0.491634492 kegg kegg NA NA no no no no no no Basal transcription factors Ether lipid metabolism 0 0.65513834 0.602831403 kegg kegg NA NA no no no no no no Basal transcription factors Glutathione metabolism 0 0 -0.415701416 kegg kegg NA NA no no no no no no Basal transcription factors Glycerolipid metabolism 0 0 0.452767053 kegg kegg NA NA no no no no no up Basal transcription factors Glycerophospholipid metabolism 0.440869565 0 0.681081081 kegg kegg NA NA no no no no no up Basal transcription factors "Glycine, serine and threonine metabolism" 0 0.42687747 -0.449163449 kegg kegg NA NA no no no no up no Basal transcription factors Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.447826087 0 0 kegg kegg NA NA no no no no no no Basal transcription factors Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.405405405 kegg kegg NA NA no no no no no no Basal transcription factors Glycosaminoglycan degradation -0.571304348 0 0 kegg kegg NA NA no no no no no up Basal transcription factors Glycosphingolipid biosynthesis - ganglio series 0 0.633399209 0 kegg kegg NA NA no no no no no no Basal transcription factors Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.446086957 0.531620553 0 kegg kegg NA NA no no no no no no Basal transcription factors Glyoxylate and dicarboxylate metabolism 0 -0.437747036 -0.424967825 kegg kegg NA NA no no no no no no Basal transcription factors Inositol phosphate metabolism 0 0.414031621 0.624195624 kegg kegg NA NA no no no no no no Basal transcription factors Linoleic acid metabolism 0 0 0.439382239 kegg kegg NA NA no no no no no no Basal transcription factors Lysine degradation 0.509565217 0.585968379 0.731016731 kegg kegg NA NA no no no no no no Basal transcription factors Mannose type O-glycan biosynthesis 0 0 0.61956242 kegg kegg NA NA no no no no no no Basal transcription factors mRNA surveillance pathway 0.597391304 0.645256917 0.735649936 kegg kegg NA NA no no no no no no Basal transcription factors Mucin type O-glycan biosynthesis 0 0.442687747 0 kegg kegg NA NA no no no no no no Basal transcription factors N-Glycan biosynthesis 0.58173913 0.648221344 0.680823681 kegg kegg NA NA no no no no no no Basal transcription factors Nicotinate and nicotinamide metabolism 0 -0.517786561 -0.444530245 kegg kegg NA NA no no no no no no Basal transcription factors Nitrogen metabolism -0.479130435 -0.456521739 -0.494208494 kegg kegg NA NA no no no no no no Basal transcription factors One carbon pool by folate 0.580869565 0.719367589 0.703474903 kegg kegg NA NA no no no no no no Basal transcription factors Other types of O-glycan biosynthesis 0.60173913 0.612648221 0.797683398 kegg kegg NA NA no no no no no no Basal transcription factors Pentose and glucuronate interconversions 0 0.59486166 0.445817246 kegg kegg NA NA no no no no no no Basal transcription factors Pentose phosphate pathway -0.703478261 -0.731225296 -0.593564994 kegg kegg NA NA no no no no no no Basal transcription factors Platinum drug resistance 0.719130435 0.635375494 0.665379665 kegg kegg NA NA no no no no no no Basal transcription factors Porphyrin and chlorophyll metabolism 0 0 -0.423680824 kegg kegg NA NA no no no no no no Basal transcription factors Propanoate metabolism 0 0.421936759 0.571685972 kegg kegg NA NA no no no no no no Basal transcription factors Purine metabolism 0 0.470355731 0 kegg kegg NA NA no no no no no no Basal transcription factors Pyrimidine metabolism 0 0.52173913 0 kegg kegg NA NA no no no no no no Basal transcription factors Pyruvate metabolism 0 0.496047431 0.490862291 kegg kegg NA NA no no no no no no Basal transcription factors Retinol metabolism 0 0.527667984 0.644530245 kegg kegg NA NA no no no no no no Basal transcription factors Ribosome 0.431304348 0 0 kegg kegg NA NA no no no no no no Basal transcription factors Ribosome biogenesis in eukaryotes 0.84173913 0.849802372 0.893693694 kegg kegg NA NA no no no no no no Basal transcription factors RNA degradation 0.592173913 0.575098814 0.767052767 kegg kegg NA NA no no no no no no Basal transcription factors RNA polymerase 0.853043478 0.82312253 0.81956242 kegg kegg NA NA no no no no no no Basal transcription factors Selenocompound metabolism 0.724347826 0.713438735 0.785070785 kegg kegg NA NA no no no no no no Basal transcription factors Sphingolipid metabolism -0.55826087 0 0 kegg kegg NA NA no no no no no no Basal transcription factors Steroid biosynthesis 0.616521739 0.678853755 0.598198198 kegg kegg NA NA no no no no no no Basal transcription factors Steroid hormone biosynthesis 0 0.437747036 0.448648649 kegg kegg NA NA no no no no no no Basal transcription factors Sulfur metabolism -0.431304348 0 -0.524324324 kegg kegg NA NA no no no no no no Basal transcription factors Synthesis and degradation of ketone bodies 0.542608696 0.7756917 0.734362934 kegg kegg NA NA no no no no no no Basal transcription factors Taurine and hypotaurine metabolism 0 0 0.411325611 kegg kegg NA NA no no no no no no Basal transcription factors Terpenoid backbone biosynthesis 0.848695652 0.824110672 0.756241956 kegg kegg NA NA no no no no no no Basal transcription factors Tryptophan metabolism 0 0 0.539253539 kegg kegg NA NA no no no no up no Basal transcription factors Tyrosine metabolism 0 0.47826087 0 kegg kegg NA NA no no no no no no Basal transcription factors Ubiquinone and other terpenoid-quinone biosynthesis 0 0.602766798 0.678507079 kegg kegg NA NA no no no no no no Basal transcription factors "Valine, leucine and isoleucine degradation" 0 0.581027668 0.611325611 kegg kegg NA NA no no no no no no Basal transcription factors Various types of N-glycan biosynthesis 0.543478261 0.619565217 0.661003861 kegg kegg NA NA no no no no no no Base excision repair 2-Oxocarboxylic acid metabolism 0 0.588932806 0 kegg kegg NA NA no no no no no no Base excision repair ABC transporters 0.49826087 0.52173913 0 kegg kegg NA NA no no no no up up Base excision repair Amino sugar and nucleotide sugar metabolism 0 0.541501976 0 kegg kegg NA NA no no no no no no Base excision repair Aminoacyl-tRNA biosynthesis 0.633043478 0.693675889 0.717117117 kegg kegg NA NA no no no no no no Base excision repair Antifolate resistance 0 0.75 0 kegg kegg NA NA no no no no no no Base excision repair Arginine and proline metabolism 0 0 -0.471299871 kegg kegg NA NA no no no no up no Base excision repair Arginine biosynthesis 0 0 -0.411583012 kegg kegg NA NA no no no no no no Base excision repair Ascorbate and aldarate metabolism 0 0 0.485456885 kegg kegg NA NA no no no no no no Base excision repair Basal transcription factors 0.76173913 0.717391304 0.847104247 kegg kegg NA NA no no no no no no Base excision repair Biosynthesis of amino acids 0 -0.52173913 -0.49034749 kegg kegg NA NA no no no no no no Base excision repair Biosynthesis of cofactors 0 0.687747036 0 kegg kegg NA NA no no no no no no Base excision repair Biosynthesis of unsaturated fatty acids 0.443478261 0 0.527670528 kegg kegg NA NA no no no no no no Base excision repair Butanoate metabolism 0 0.503952569 0.666924067 kegg kegg NA NA no no no no no no Base excision repair Citrate cycle (TCA cycle) 0 0.466403162 0.659459459 kegg kegg NA NA no no no no no no Base excision repair Cysteine and methionine metabolism 0.473913043 0.43972332 0.736936937 kegg kegg NA NA no no no no no no Base excision repair DNA replication 0.800869565 0.739130435 0.841184041 kegg kegg NA NA no no no no no no Base excision repair Drug metabolism - cytochrome P450 0 0.4743083 0 kegg kegg NA NA no no no no no no Base excision repair EGFR tyrosine kinase inhibitor resistance 0.514782609 0 0.51042471 kegg kegg NA NA no no no no no no Base excision repair Ether lipid metabolism 0 0.470355731 0.533075933 kegg kegg NA NA no no no no no no Base excision repair Fatty acid elongation 0 0 0.51969112 kegg kegg NA NA no no no no no no Base excision repair Glycerolipid metabolism 0 0.419960474 0 kegg kegg NA NA no no no no no up Base excision repair Glycerophospholipid metabolism 0 0.457509881 0.498069498 kegg kegg NA NA no no no no no up Base excision repair "Glycine, serine and threonine metabolism" 0 0.524703557 0 kegg kegg NA NA no no no no up no Base excision repair Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.549407115 0 kegg kegg NA NA no no no no no no Base excision repair Glycosaminoglycan degradation -0.756521739 -0.520750988 0 kegg kegg NA NA no no no no no up Base excision repair Glycosphingolipid biosynthesis - ganglio series 0 0.68972332 0 kegg kegg NA NA no no no no no no Base excision repair Glycosphingolipid biosynthesis - globo and isoglobo series -0.474782609 0 0 kegg kegg NA NA no no no no no no Base excision repair Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.646086957 0.524703557 0.410810811 kegg kegg NA NA no no no no no no Base excision repair Inositol phosphate metabolism 0 0.541501976 0.481338481 kegg kegg NA NA no no no no no no Base excision repair Linoleic acid metabolism 0 0 0.40978121 kegg kegg NA NA no no no no no no Base excision repair Lysine degradation 0.63826087 0.711462451 0.537194337 kegg kegg NA NA no no no no no no Base excision repair Mannose type O-glycan biosynthesis 0 0.481225296 0.417503218 kegg kegg NA NA no no no no no no Base excision repair mRNA surveillance pathway 0 0.491106719 0.487001287 kegg kegg NA NA no no no no no no Base excision repair Mucin type O-glycan biosynthesis 0 0.488142292 0 kegg kegg NA NA no no no no no no Base excision repair N-Glycan biosynthesis 0.686086957 0.635375494 0.637323037 kegg kegg NA NA no no no no no no Base excision repair Nicotinate and nicotinamide metabolism 0 -0.463438735 -0.467438867 kegg kegg NA NA no no no no no no Base excision repair Nitrogen metabolism 0 0 -0.497812098 kegg kegg NA NA no no no no no no Base excision repair One carbon pool by folate 0.688695652 0.789525692 0.724324324 kegg kegg NA NA no no no no no no Base excision repair Other types of O-glycan biosynthesis 0.6 0.716403162 0.648133848 kegg kegg NA NA no no no no no no Base excision repair Pentose and glucuronate interconversions 0 0.518774704 0.586872587 kegg kegg NA NA no no no no no no Base excision repair Pentose phosphate pathway -0.526086957 -0.678853755 -0.495238095 kegg kegg NA NA no no no no no no Base excision repair Platinum drug resistance 0.837391304 0.723320158 0.636036036 kegg kegg NA NA no no no no no no Base excision repair PPAR signaling pathway 0 -0.499011858 -0.645559846 kegg kegg NA NA no no no no no no Base excision repair Primary bile acid biosynthesis 0.519130435 0 0 kegg kegg NA NA no no no no no no Base excision repair Propanoate metabolism 0.450434783 0 0.704247104 kegg kegg NA NA no no no no no no Base excision repair Protein export 0.575652174 0 0.469240669 kegg kegg NA NA no no no no no no Base excision repair Purine metabolism 0 0.52173913 0 kegg kegg NA NA no no no no no no Base excision repair Pyrimidine metabolism 0 0.66798419 0 kegg kegg NA NA no no no no no no Base excision repair Pyruvate metabolism 0.519130435 0.449604743 0.695238095 kegg kegg NA NA no no no no no no Base excision repair Retinol metabolism 0 0.695652174 0.691377091 kegg kegg NA NA no no no no no no Base excision repair Ribosome biogenesis in eukaryotes 0.884347826 0.813241107 0.789189189 kegg kegg NA NA no no no no no no Base excision repair RNA degradation 0 0.491106719 0.564221364 kegg kegg NA NA no no no no no no Base excision repair RNA polymerase 0.773913043 0.709486166 0.762419562 kegg kegg NA NA no no no no no no Base excision repair RNA transport 0.651304348 0 0.414414414 kegg kegg NA NA no no no no no no Base excision repair Selenocompound metabolism 0.766086957 0.799407115 0.75984556 kegg kegg NA NA no no no no no no Base excision repair Sphingolipid metabolism -0.64 0 0 kegg kegg NA NA no no no no no no Base excision repair Spliceosome 0.880869565 0.757905138 0.679021879 kegg kegg NA NA no no no no no no Base excision repair Steroid biosynthesis 0 0.438735178 0.720978121 kegg kegg NA NA no no no no no no Base excision repair Steroid hormone biosynthesis 0 0 0.412612613 kegg kegg NA NA no no no no no no Base excision repair Synthesis and degradation of ketone bodies 0.584347826 0.731225296 0.752123552 kegg kegg NA NA no no no no no no Base excision repair Taurine and hypotaurine metabolism 0.437391304 0 0 kegg kegg NA NA no no no no no no Base excision repair Terpenoid backbone biosynthesis 0.635652174 0.593873518 0.614671815 kegg kegg NA NA no no no no no no Base excision repair Tryptophan metabolism 0 0 0.584041184 kegg kegg NA NA no no no no up no Base excision repair Tyrosine metabolism 0 0.492094862 0.527927928 kegg kegg NA NA no no no no no no Base excision repair Ubiquinone and other terpenoid-quinone biosynthesis 0 0.712450593 0.728442728 kegg kegg NA NA no no no no no no Base excision repair "Valine, leucine and isoleucine degradation" 0.52173913 0.570158103 0.763449163 kegg kegg NA NA no no no no no no Base excision repair Various types of N-glycan biosynthesis 0.646956522 0.68972332 0.632432432 kegg kegg NA NA no no no no no no beta-Alanine metabolism Ascorbate and aldarate metabolism 0.527826087 0.592885375 0.505791506 kegg kegg NA NA no no no no no no beta-Alanine metabolism Citrate cycle (TCA cycle) 0.717391304 0.719367589 0.567824968 kegg kegg NA NA no no no no no no beta-Alanine metabolism Cysteine and methionine metabolism 0 0.622529644 0.46023166 kegg kegg NA NA no no no no no no beta-Alanine metabolism Fatty acid degradation 0.555652174 0 0.575032175 kegg kegg NA NA no no no no no no beta-Alanine metabolism Fatty acid elongation 0.82173913 0.847826087 0.795109395 kegg kegg NA NA no no no no no no beta-Alanine metabolism Fructose and mannose metabolism 0.805217391 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Galactose metabolism 0.857391304 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Glycolysis / Gluconeogenesis 0.848695652 0.681818182 0.845302445 kegg kegg NA NA no no no no no no beta-Alanine metabolism Histidine metabolism 0.723478261 0.703557312 0.763706564 kegg kegg NA NA no no no no no no beta-Alanine metabolism Oxidative phosphorylation -0.693043478 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Pentose and glucuronate interconversions 0.535652174 0.574110672 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Pentose phosphate pathway 0.431304348 0 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Phenylalanine metabolism 0.757391304 0.773715415 0.512226512 kegg kegg NA NA no no no no no no beta-Alanine metabolism Primary bile acid biosynthesis 0.716521739 0.750988142 0.743114543 kegg kegg NA NA no no no no no no beta-Alanine metabolism Pyrimidine metabolism 0.793913043 0.422924901 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Steroid biosynthesis 0 0.646245059 0.453024453 kegg kegg NA NA no no no no no no beta-Alanine metabolism Steroid hormone biosynthesis 0.63826087 0.772727273 0 kegg kegg NA NA no no no no no no beta-Alanine metabolism Synthesis and degradation of ketone bodies 0.467826087 0.468379447 0.463835264 kegg kegg NA NA no no no no no no beta-Alanine metabolism Tryptophan metabolism 0.899130435 0.90513834 0.751351351 kegg kegg NA NA no no no no up no beta-Alanine metabolism Tyrosine metabolism 0.74173913 0.73715415 0.803603604 kegg kegg NA NA no no no no no no beta-Alanine metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.733043478 0.668972332 0.416988417 kegg kegg NA NA no no no no no no beta-Alanine metabolism "Valine, leucine and isoleucine degradation" 0.780869565 0.725296443 0.774259974 kegg kegg NA NA no no no no no no Betaine+blood 14:0-LPC+blood 0 0 -0.489230769 serum_choline serum_phospholipids 0.857 0.00689 no no no up up no Betaine+blood 14:0/16:0-PC+blood 0 -0.509803922 -0.526837607 serum_choline serum_phospholipids 0.857 0.0358 no no no no up no Betaine+blood 14:0/18:0-PC+blood 0 -0.536764706 -0.652649573 serum_choline serum_phospholipids 0.857 0.00289 no no no up up no Betaine+blood 14:0/18:2-PC+blood -0.497744361 0 -0.445470085 serum_choline serum_phospholipids 0.857 0.102 no no no no up no Betaine+blood 14:0/20:4-PC+blood -0.511278195 0 0 serum_choline serum_phospholipids 0.857 0.486 no no no no no no Betaine+blood 14:0+blood 0 0 -0.45982906 yes serum_choline serum_fattyacid 0.857 0.00572 no no no up no dn Betaine+blood 16:0-LPC+blood 0 0.580882353 0 serum_choline serum_phospholipids 0.857 0.00456 no no no up up no Betaine+blood 16:0/16:0-PI+blood 0 0 -0.493333333 serum_choline serum_phospholipids 0.857 0.358 no no no no no no Betaine+blood 16:0/16:1-PC+blood 0 -0.595588235 -0.688205128 serum_choline serum_phospholipids 0.857 0.00283 no no no up up no Betaine+blood 16:0/16:1-PI+blood 0 0 -0.556239316 serum_choline serum_phospholipids 0.857 0.262 no no no no no no Betaine+blood 16:0/18:2-PI+blood 0 0 -0.451623932 serum_choline serum_phospholipids 0.857 0.269 no no no no no no Betaine+blood 16:0/18:3-PC+blood 0 0 -0.530940171 serum_choline serum_phospholipids 0.857 0.00216 no no no no up up Betaine+blood 16:0/20:4-PI+blood 0 0 -0.512478632 serum_choline serum_phospholipids 0.857 0.558 no no no no no no Betaine+blood 16:0/20:5-PC+blood -0.672180451 0 0 serum_choline serum_phospholipids 0.857 0.628 no no no no no no Betaine+blood 16:0/22:0-PE+blood 0 0 0.420854701 serum_choline serum_phospholipids 0.857 0.00839 no no no dn no up Betaine+blood 16:0+blood 0 0 -0.530940171 yes serum_choline serum_fattyacid 0.857 0.00876 no no no up no no Betaine+blood 16:1-LPC+blood 0 0 -0.490598291 serum_choline serum_phospholipids 0.857 0.0241 no no no no up no Betaine+blood 16:1/18:1-PG+blood 0.448120301 0 0 serum_choline serum_phospholipids 0.857 3.21E-05 no no no no up up Betaine+blood 16:1/18:2-PG+blood 0.45112782 0 0 serum_choline serum_phospholipids 0.857 1.40E-08 no no no no up up Betaine+blood 16:1+blood 0 0 -0.444102564 yes serum_choline serum_fattyacid 0.857 0.0186 no no no no no dn Betaine+blood 18:0-LPC+blood 0 0 0.42017094 serum_choline serum_phospholipids 0.857 0.554 no no no no no no Betaine+blood 18:0/18:0-PC+blood 0 -0.602941176 0 serum_choline serum_phospholipids 0.857 0.426 no no no no no no Betaine+blood 18:0/18:1-PC+blood 0 -0.637254902 0 serum_choline serum_phospholipids 0.857 0.393 no no no no no no Betaine+blood 18:0/18:1-PG+blood 0 0 -0.494017094 serum_choline serum_phospholipids 0.857 0.000842 no no no no up no Betaine+blood 18:0/20:2-PC+blood 0 -0.490196078 0.406495726 serum_choline serum_phospholipids 0.857 0.733 no no no no no no Betaine+blood 18:0/20:3-PC+blood 0 -0.661764706 0 serum_choline serum_phospholipids 0.857 0.0682 no no no no up no Betaine+blood 18:0/20:5-PC+blood 0 0 0.405128205 serum_choline serum_phospholipids 0.857 0.17 no no no no no no Betaine+blood 18:1-LPC+blood 0 0 0.450940171 serum_choline serum_phospholipids 0.857 0.179 no no no no no no Betaine+blood 18:1/16:1-PE+blood 0 -0.490196078 -0.413333333 serum_choline serum_phospholipids 0.857 0.000184 no no no up up no Betaine+blood 18:1/18:0-PE+blood 0 0 -0.448205128 serum_choline serum_phospholipids 0.857 1.39E-06 no no no up up no Betaine+blood 18:1/18:1-PE+blood 0 -0.551470588 -0.422905983 serum_choline serum_phospholipids 0.857 1.03E-05 no no no up up no Betaine+blood 18:1/18:1-PG+blood 0 -0.62745098 0 serum_choline serum_phospholipids 0.857 0.00352 no no no no up up Betaine+blood 18:2-LPC+blood 0 0.593137255 0 serum_choline serum_phospholipids 0.857 0.00743 no no no dn no up Betaine+blood 18:3/16:0-PE+blood 0 0 -0.617777778 serum_choline serum_phospholipids 0.857 0.00149 no no no up up no Betaine+blood 18:3n3+blood 0 0.485294118 0 serum_choline serum_fattyacid 0.857 0.291 no no no no no no Betaine+blood 18:3n6+blood -0.511278195 0 0 serum_choline serum_fattyacid 0.857 0.0463 no no no up no dn Betaine+blood 20:1-LPC+blood 0 0 0.655384615 serum_choline serum_phospholipids 0.857 0.217 no no no no no no Betaine+blood 20:2/18:0-PC+blood 0 -0.671568627 0 serum_choline serum_phospholipids 0.857 0.0427 no no no no up no Betaine+blood 20:2/18:1-PE+blood 0 -0.649509804 -0.437264957 serum_choline serum_phospholipids 0.857 0.00208 no no no up up no Betaine+blood 20:2+blood 0 0 0.413333333 serum_choline serum_fattyacid 0.857 0.478 no no no no no no Betaine+blood 20:3n6+blood 0 -0.549019608 0 serum_choline serum_fattyacid 0.857 0.0884 no no no up no no Betaine+blood 20:4-LPC+blood 0 0.654411765 0 serum_choline serum_phospholipids 0.857 0.949 no no no no no no Betaine+blood 20:5-LPC+blood -0.652631579 0 0 serum_choline serum_phospholipids 0.857 0.558 no no no no no no Betaine+blood 20:5n3+blood -0.685714286 0 0 serum_choline serum_fattyacid 0.857 0.988 no no no no no no Betaine+blood 8-HETE+blood 0 0.519607843 0 serum_choline serum_ARA 0.857 0.741 no no no no no no Betaine+blood "9,10-EPOME+blood" -0.456326732 0 0 serum_choline serum_ARA 0.857 0.801 no no no no no no Betaine+blood AA+blood 0 0.529411765 0.444102564 serum_choline serum_ARA 0.857 0.212 no no no no no no Betaine+blood Adrenergic signaling in cardiomyocytes 0 0 -0.566923077 serum_choline kegg 0.857 NA no no no no no up Betaine+blood Aldosterone synthesis and secretion 0 0 -0.477692308 serum_choline kegg 0.857 NA no no no no up up Betaine+blood Alistipes 0 -0.497854171 0 serum_choline Genus 0.857 0.0114 no no no no up no Betaine+blood Alzheimer disease 0 0 -0.412307692 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Amphetamine addiction 0 0 -0.568461538 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Apoptosis 0 0 0.433846154 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Biosynthesis of amino acids 0 0 0.493846154 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Calcium signaling pathway 0 0 -0.453076923 serum_choline kegg 0.857 NA no no no no up up Betaine+blood Carbon metabolism 0 0 0.486153846 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Cocaine addiction 0 0 -0.420769231 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Complement and coagulation cascades 0 0 0.409230769 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Coprococcus -0.545864662 0 0.455726496 butyrate-producing serum_choline Genus 0.857 0.612 no no no no no no Betaine+blood Cushing syndrome 0 0 -0.426923077 serum_choline kegg 0.857 NA no no no no no up Betaine+blood Dopaminergic synapse 0 0 -0.551538462 serum_choline kegg 0.857 NA no no no no up no Betaine+blood EGFR tyrosine kinase inhibitor resistance 0 0 -0.416153846 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Fc epsilon RI signaling pathway 0 0 0.473846154 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Fc gamma R-mediated phagocytosis 0 0 0.436153846 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Fluid shear stress and atherosclerosis 0 0 0.422307692 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Glucagon signaling pathway 0 0 -0.538461538 serum_choline kegg 0.857 NA no no no no no no Betaine+blood GnRH signaling pathway 0 0 -0.512307692 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Inflammatory mediator regulation of TRP channels 0 0 -0.453076923 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Long-term potentiation 0 0 -0.414615385 serum_choline kegg 0.857 NA no no no no no up Betaine+blood Lysosome 0 0 0.500769231 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Melanogenesis 0 0 -0.516923077 serum_choline kegg 0.857 NA no no no no no no Betaine+blood mRNA surveillance pathway 0 0 -0.403846154 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Neuroactive ligand-receptor interaction 0 0 0.420769231 serum_choline kegg 0.857 NA no no no up up up Betaine+blood Non-alcoholic fatty liver disease 0 0 -0.442307692 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Paraprevotella 0 0 0.408895201 serum_choline Genus 0.857 0.118 no no no no no no Betaine+blood "Parathyroid hormone synthesis, secretion and action" 0 0 -0.475384615 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Pathogenic Escherichia coli infection 0 0 0.462307692 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Protein processing in endoplasmic reticulum 0 0 -0.451538462 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Salmonella infection 0 0 0.424615385 serum_choline kegg 0.857 NA no no no no no no Betaine+blood Tuberculosis 0 0 0.504615385 serum_choline kegg 0.857 NA no no no no no dn Betaine+blood Vascular smooth muscle contraction 0 0 -0.487692308 serum_choline kegg 0.857 NA no no no no no no Bile secretion 2-Oxocarboxylic acid metabolism 0 0 -0.622908623 kegg kegg NA NA no no no no no no Bile secretion ABC transporters -0.615652174 0 -0.428056628 kegg kegg NA NA no no no no up up Bile secretion Adipocytokine signaling pathway 0 0 0.575804376 kegg kegg NA NA no no no no no no Bile secretion Adrenergic signaling in cardiomyocytes 0.715652174 0.57312253 0.404890605 kegg kegg NA NA no no no no no up Bile secretion "Alanine, aspartate and glutamate metabolism" -0.464347826 0 0 kegg kegg NA NA no no no no no no Bile secretion Aldosterone synthesis and secretion 0.806956522 0.66798419 0.525096525 kegg kegg NA NA no no no no up up Bile secretion alpha-Linolenic acid metabolism -0.524347826 0 -0.569111969 kegg kegg NA NA no no no no no no Bile secretion Aminoacyl-tRNA biosynthesis -0.493043478 0 0 kegg kegg NA NA no no no no no no Bile secretion AMPK signaling pathway 0 0 0.672844273 kegg kegg NA NA no no no no no no Bile secretion Arachidonic acid metabolism 0 0.587944664 0.416988417 kegg kegg NA NA no no no no no no Bile secretion Arginine and proline metabolism -0.460869565 0 0 kegg kegg NA NA no no no no up no Bile secretion Arginine biosynthesis -0.42173913 0 0 kegg kegg NA NA no no no no no no Bile secretion Ascorbate and aldarate metabolism 0 0 -0.718404118 kegg kegg NA NA no no no no no no Bile secretion Autophagy - other 0 -0.511857708 -0.407722008 kegg kegg NA NA no no no no no no Bile secretion Base excision repair -0.473043478 0 0 kegg kegg NA NA no no no no no no Bile secretion beta-Alanine metabolism -0.409565217 0 0 kegg kegg NA NA no no no no no no Bile secretion Biosynthesis of cofactors 0 0 0.581209781 kegg kegg NA NA no no no no no no Bile secretion Butanoate metabolism -0.417391304 0 0 kegg kegg NA NA no no no no no no Bile secretion Calcium signaling pathway 0.583478261 0.703557312 0 kegg kegg NA NA no no no no up up Bile secretion cAMP signaling pathway 0.503478261 0 0.496782497 yes kegg kegg NA NA no no no no up up Bile secretion Carbohydrate digestion and absorption 0 0 -0.508108108 kegg kegg NA NA no no no no no no Bile secretion Cardiac muscle contraction 0.467826087 0.488142292 0 kegg kegg NA NA no no no no no up Bile secretion Cell adhesion molecules 0 -0.47826087 0 kegg kegg NA NA no no no no no no Bile secretion Cholinergic synapse 0 0 -0.432947233 kegg kegg NA NA no no no no no no Bile secretion Circadian entrainment 0.766086957 0.729249012 0.778893179 kegg kegg NA NA no no no no up up Bile secretion Citrate cycle (TCA cycle) 0 0 -0.614414414 kegg kegg NA NA no no no no no no Bile secretion Cortisol synthesis and secretion 0.824347826 0.730237154 0.728442728 kegg kegg NA NA no no no no no up Bile secretion Cushing syndrome 0.746956522 0.590909091 0.470527671 kegg kegg NA NA no no no no no up Bile secretion DNA replication -0.428695652 0 -0.467696268 kegg kegg NA NA no no no no no no Bile secretion Dopaminergic synapse 0.708695652 0.732213439 0.46975547 kegg kegg NA NA no no no no up no Bile secretion Drug metabolism - other enzymes 0 0 -0.63963964 kegg kegg NA NA no no no no no no Bile secretion Endocrine and other factor-regulated calcium reabsorption 0.897391304 0.82312253 0.81003861 kegg kegg NA NA no no no no no no Bile secretion Endocrine resistance 0.709565217 0.70256917 0.699099099 kegg kegg NA NA no no no no no no Bile secretion Estrogen signaling pathway 0 0 0.497554698 kegg kegg NA NA no no no no no no Bile secretion Fanconi anemia pathway -0.427826087 0 -0.433204633 kegg kegg NA NA no no no no no no Bile secretion Fat digestion and absorption 0 0 -0.42960103 yes kegg kegg NA NA no no no no up up Bile secretion Fatty acid degradation -0.608695652 -0.499011858 -0.460746461 kegg kegg NA NA no no no no no no Bile secretion Fatty acid metabolism -0.619130435 -0.458498024 0 kegg kegg NA NA no no no no no no Bile secretion Fc gamma R-mediated phagocytosis -0.407826087 0 0 kegg kegg NA NA no no no no no no Bile secretion Ferroptosis 0.619130435 0.514822134 0.603346203 kegg kegg NA NA no no no no no no Bile secretion Fructose and mannose metabolism -0.423478261 0 -0.422908623 kegg kegg NA NA no no no no no no Bile secretion Galactose metabolism -0.482608696 -0.420948617 -0.647876448 kegg kegg NA NA no no no no no no Bile secretion Gap junction 0.859130435 0.750988142 0.877477477 kegg kegg NA NA no no no no no no Bile secretion Gastric acid secretion 0.6 0.599802372 0 kegg kegg NA NA no no no no no no Bile secretion Glucagon signaling pathway 0.611304348 0.579051383 0 kegg kegg NA NA no no no no no no Bile secretion Glutamatergic synapse 0.717391304 0.460474308 0.851222651 kegg kegg NA NA no no no no up up Bile secretion Glutathione metabolism 0 0.517786561 0.598198198 kegg kegg NA NA no no no no no no Bile secretion Glycerolipid metabolism -0.50173913 0 -0.701930502 kegg kegg NA NA no no no no no up Bile secretion Glycerophospholipid metabolism 0 0 -0.61956242 kegg kegg NA NA no no no no no up Bile secretion "Glycine, serine and threonine metabolism" 0 0 0.61003861 kegg kegg NA NA no no no no up no Bile secretion Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0 -0.436808237 kegg kegg NA NA no no no no no no Bile secretion Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.680566281 kegg kegg NA NA no no no no no no Bile secretion Glycosaminoglycan biosynthesis - keratan sulfate 0.439130435 0 0 kegg kegg NA NA no no no no no no Bile secretion Glycosaminoglycan degradation 0 0 -0.735392535 kegg kegg NA NA no no no no no up Bile secretion Glyoxylate and dicarboxylate metabolism -0.604347826 0 0 kegg kegg NA NA no no no no no no Bile secretion GnRH secretion 0 0 -0.484427284 kegg kegg NA NA no no no no up up Bile secretion GnRH signaling pathway 0.755652174 0.734189723 0.615958816 kegg kegg NA NA no no no no no no Bile secretion "Growth hormone synthesis, secretion and action" 0.437391304 0.432806324 0.517631918 kegg kegg NA NA no no no no no no Bile secretion Hedgehog signaling pathway 0 0 -0.487258687 kegg kegg NA NA no no no no no no Bile secretion Hippo signaling pathway - multiple species 0 0 -0.581209781 kegg kegg NA NA no no no no no no Bile secretion Histidine metabolism -0.476521739 0 -0.48030888 kegg kegg NA NA no no no no no no Bile secretion Homologous recombination -0.433043478 0 0 kegg kegg NA NA no no no no no no Bile secretion Inflammatory mediator regulation of TRP channels 0.753913043 0.660079051 0.565508366 kegg kegg NA NA no no no no no no Bile secretion Inositol phosphate metabolism -0.434782609 0 -0.550579151 kegg kegg NA NA no no no no no no Bile secretion Insulin secretion 0.749565217 0.710474308 0.67027027 yes kegg kegg NA NA no no no no up up Bile secretion Long-term depression 0.909565217 0.742094862 0.866409266 kegg kegg NA NA no no no no no no Bile secretion Longevity regulating pathway 0 0 0.598455598 kegg kegg NA NA no no no no no no Bile secretion Longevity regulating pathway - multiple species 0 -0.621541502 0 kegg kegg NA NA no no no no no no Bile secretion Lysine degradation 0 0 -0.531016731 kegg kegg NA NA no no no no no no Bile secretion Mannose type O-glycan biosynthesis 0 0 -0.50990991 kegg kegg NA NA no no no no no no Bile secretion MAPK signaling pathway 0 -0.536561265 -0.608236808 kegg kegg NA NA no no no no no no Bile secretion Maturity onset diabetes of the young 0 0 -0.492664093 kegg kegg NA NA no no no no up no Bile secretion Melanogenesis 0.808695652 0.684782609 0.625740026 kegg kegg NA NA no no no no no no Bile secretion Mismatch repair -0.44173913 0 0 kegg kegg NA NA no no no no no no Bile secretion Mitophagy - animal 0.586086957 0.562252964 0.511196911 kegg kegg NA NA no no no no no no Bile secretion Mucin type O-glycan biosynthesis 0 -0.62944664 0 kegg kegg NA NA no no no no no no Bile secretion Necroptosis 0.664347826 0.51284585 0.631402831 kegg kegg NA NA no no no no no no Bile secretion Neuroactive ligand-receptor interaction 0 -0.425889328 0 kegg kegg NA NA no no no up up up Bile secretion NF-kappa B signaling pathway -0.611304348 0 0 kegg kegg NA NA no no no no no no Bile secretion Nicotinate and nicotinamide metabolism -0.448695652 0 0 kegg kegg NA NA no no no no no no Bile secretion NOD-like receptor signaling pathway -0.56173913 -0.507905138 0 kegg kegg NA NA no no no no no no Bile secretion Non-alcoholic fatty liver disease 0.482608696 0.513833992 0 kegg kegg NA NA no no no no no no Bile secretion Notch signaling pathway 0 0 -0.654568855 kegg kegg NA NA no no no no no no Bile secretion Nucleotide excision repair -0.436521739 0 0 kegg kegg NA NA no no no no no no Bile secretion One carbon pool by folate 0 0 -0.458429858 kegg kegg NA NA no no no no no no Bile secretion Osteoclast differentiation -0.453913043 -0.447628458 0 kegg kegg NA NA no no no no no no Bile secretion Other glycan degradation -0.585217391 -0.416996047 -0.699099099 kegg kegg NA NA no no no no no no Bile secretion Other types of O-glycan biosynthesis 0 0 -0.484169884 kegg kegg NA NA no no no no no no Bile secretion Ovarian steroidogenesis 0.852173913 0.909090909 0.932818533 kegg kegg NA NA no no no no up up Bile secretion Oxidative phosphorylation 0.427826087 0.489130435 0 kegg kegg NA NA no no no no no no Bile secretion Oxytocin signaling pathway 0 0.450592885 0.404633205 kegg kegg NA NA no no no no no no Bile secretion Pancreatic secretion 0.900869565 0.807312253 0.805920206 kegg kegg NA NA no no no no no no Bile secretion "Parathyroid hormone synthesis, secretion and action" 0.594782609 0.621541502 0.491891892 kegg kegg NA NA no no no no no no Bile secretion Pentose and glucuronate interconversions 0 0 -0.517117117 kegg kegg NA NA no no no no no no Bile secretion Peroxisome -0.622608696 -0.489130435 0 kegg kegg NA NA no no no no no no Bile secretion Phosphatidylinositol signaling system 0 0 -0.465122265 kegg kegg NA NA no no no no no no Bile secretion Platelet activation 0.508695652 0.5256917 0 kegg kegg NA NA no no no no no no Bile secretion Porphyrin and chlorophyll metabolism 0 0 0.602574003 kegg kegg NA NA no no no no no no Bile secretion PPAR signaling pathway 0 -0.519762846 0 kegg kegg NA NA no no no no no no Bile secretion Primary bile acid biosynthesis -0.450434783 0 0 kegg kegg NA NA no no no no no no Bile secretion Progesterone-mediated oocyte maturation 0 0 -0.517117117 kegg kegg NA NA no no no no no no Bile secretion Proteasome 0 0 -0.570913771 kegg kegg NA NA no no no no no no Bile secretion Protein digestion and absorption -0.62173913 -0.603754941 0 yes kegg kegg NA NA no no no no up up Bile secretion Purine metabolism 0 0 0.412870013 kegg kegg NA NA no no no no no no Bile secretion Pyrimidine metabolism -0.508695652 0 -0.470785071 kegg kegg NA NA no no no no no no Bile secretion Rap1 signaling pathway 0.473043478 0.501976285 0 kegg kegg NA NA no no no no no no Bile secretion Regulation of lipolysis in adipocytes 0.911304348 0.914031621 0.882882883 kegg kegg NA NA no no no no no no Bile secretion Relaxin signaling pathway 0.431304348 0 0.483140283 kegg kegg NA NA no no no no no no Bile secretion Renin secretion 0.76173913 0.68083004 0.843500644 kegg kegg NA NA no no no no no no Bile secretion Retinol metabolism 0 0 -0.544916345 kegg kegg NA NA no no no no no no Bile secretion Retrograde endocannabinoid signaling 0 0.499011858 0 kegg kegg NA NA no no no no no up Bile secretion Ribosome biogenesis in eukaryotes 0 0 -0.42033462 kegg kegg NA NA no no no no no no Bile secretion RNA degradation 0 0 -0.493693694 kegg kegg NA NA no no no no no no Bile secretion RNA transport -0.426956522 0 0 kegg kegg NA NA no no no no no no Bile secretion Salivary secretion 0.72173913 0.616600791 0.73024453 kegg kegg NA NA no no no no no no Bile secretion Selenocompound metabolism 0 0 -0.562676963 kegg kegg NA NA no no no no no no Bile secretion Serotonergic synapse 0.611304348 0.659090909 0.697812098 kegg kegg NA NA no no no no no no Bile secretion SNARE interactions in vesicular transport -0.706956522 -0.529644269 -0.423423423 kegg kegg NA NA no no no no no no Bile secretion Sphingolipid metabolism 0 0 -0.523294723 kegg kegg NA NA no no no no no no Bile secretion Sphingolipid signaling pathway 0 -0.41798419 -0.428571429 kegg kegg NA NA no no no no no no Bile secretion Starch and sucrose metabolism 0 0 -0.515572716 kegg kegg NA NA no no no no no no Bile secretion Steroid hormone biosynthesis 0 0 -0.585842986 kegg kegg NA NA no no no no no no Bile secretion T cell receptor signaling pathway 0 -0.631422925 0 kegg kegg NA NA no no no no no no Bile secretion Taste transduction 0 0 -0.599485199 kegg kegg NA NA no no no no no up Bile secretion Terpenoid backbone biosynthesis 0 0 -0.483912484 kegg kegg NA NA no no no no no no Bile secretion Th1 and Th2 cell differentiation 0 -0.544466403 -0.50990991 kegg kegg NA NA no no no no no no Bile secretion Th17 cell differentiation 0 -0.635375494 -0.494208494 kegg kegg NA NA no no no no no no Bile secretion Thermogenesis 0.497391304 0.463438735 0 kegg kegg NA NA no no no no no no Bile secretion Thyroid hormone signaling pathway 0 0.518774704 0 kegg kegg NA NA no no no no no no Bile secretion Thyroid hormone synthesis 0.643478261 0.81027668 0.773745174 kegg kegg NA NA no no no no no no Bile secretion Tryptophan metabolism -0.467826087 0 -0.463835264 kegg kegg NA NA no no no no up no Bile secretion Type II diabetes mellitus 0 0 -0.487516088 kegg kegg NA NA no no no no no no Bile secretion Ubiquinone and other terpenoid-quinone biosynthesis -0.444347826 0 0 kegg kegg NA NA no no no no no no Bile secretion Ubiquitin mediated proteolysis 0.566956522 0.543478261 0.494723295 kegg kegg NA NA no no no no no no Bile secretion "Valine, leucine and isoleucine degradation" -0.468695652 0 0 kegg kegg NA NA no no no no no no Bile secretion Various types of N-glycan biosynthesis 0 0 -0.402831403 kegg kegg NA NA no no no no no no Bile secretion Vascular smooth muscle contraction 0.703478261 0.650197628 0.62007722 kegg kegg NA NA no no no no no no Bile secretion Vasopressin-regulated water reabsorption 0.910434783 0.865612648 0.816216216 kegg kegg NA NA no no no no no no Bile secretion VEGF signaling pathway 0 0 -0.475675676 kegg kegg NA NA no no no no no no Bile secretion Viral protein interaction with cytokine and cytokine receptor 0 0 0.429343629 kegg kegg NA NA no no no no no no Bile secretion Wnt signaling pathway 0 0 -0.492664093 kegg kegg NA NA no no no no no no Bilophila Turicibacter 0 0.576532599 0 Genus Genus 0.528 0.269 no no no no no no Biosynthesis of amino acids 2-Oxocarboxylic acid metabolism 0.593043478 -0.5 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids "Alanine, aspartate and glutamate metabolism" 0.410434783 0.717391304 0.679279279 kegg kegg NA NA no no no no no no Biosynthesis of amino acids alpha-Linolenic acid metabolism 0.754782609 0.5 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Amino sugar and nucleotide sugar metabolism 0.640869565 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Aminoacyl-tRNA biosynthesis 0 -0.464426877 -0.450965251 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Arachidonic acid metabolism 0 0 0.441698842 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Arginine and proline metabolism 0.410434783 0.685770751 0.493436293 kegg kegg NA NA no no no no up no Biosynthesis of amino acids Arginine biosynthesis 0.492173913 0.773715415 0.764221364 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Ascorbate and aldarate metabolism 0 -0.437747036 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Bacteroides 0.423478261 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Biosynthesis of amino acids beta-Alanine metabolism 0.763478261 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Butanoate metabolism 0.57826087 -0.42687747 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Carbon metabolism 0.913913043 0.524703557 0.864607465 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Coprococcus 0 0 0.410322415 butyrate-producing kegg Genus NA 0.612 no no no no no no Biosynthesis of amino acids Drug metabolism - cytochrome P450 0 -0.496047431 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Drug metabolism - other enzymes 0.711304348 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Ether lipid metabolism -0.704347826 -0.7243083 -0.544401544 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Fatty acid biosynthesis 0 0.759881423 0.475675676 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Fatty acid degradation 0.642608696 0.674901186 0.46023166 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Fatty acid elongation 0.607826087 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Fatty acid metabolism 0.704347826 0.747035573 0.498841699 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Folate biosynthesis 0 -0.572134387 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Fructose and mannose metabolism 0.773043478 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Galactose metabolism 0.728695652 0.492094862 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Glutathione metabolism 0 -0.504940711 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Glycerolipid metabolism 0 0 -0.480823681 kegg kegg NA NA no no no no no up Biosynthesis of amino acids Glycerophospholipid metabolism 0 0 -0.627027027 kegg kegg NA NA no no no no no up Biosynthesis of amino acids "Glycine, serine and threonine metabolism" 0 -0.451581028 0 kegg kegg NA NA no no no no up no Biosynthesis of amino acids Glycolysis / Gluconeogenesis 0.786956522 0 0.51994852 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.414031621 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.493043478 -0.446640316 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Glycosaminoglycan biosynthesis - keratan sulfate -0.513043478 -0.520750988 -0.607979408 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Glycosaminoglycan degradation 0 0.498023715 0 kegg kegg NA NA no no no no no up Biosynthesis of amino acids Glycosphingolipid biosynthesis - lacto and neolacto series -0.463478261 0 -0.435778636 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.497035573 -0.438610039 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Glyoxylate and dicarboxylate metabolism 0.584347826 0.81027668 0.789446589 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Inositol phosphate metabolism 0 0 -0.514800515 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Lysine degradation 0 -0.606719368 -0.741570142 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Mannose type O-glycan biosynthesis -0.576521739 -0.613636364 -0.750579151 kegg kegg NA NA no no no no no no Biosynthesis of amino acids N-Glycan biosynthesis 0 -0.755928854 -0.62033462 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Nicotinate and nicotinamide metabolism 0.467826087 0.765810277 0.696010296 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Nitrogen metabolism 0.52173913 0.7243083 0.62033462 kegg kegg NA NA no no no no no no Biosynthesis of amino acids One carbon pool by folate 0 -0.639328063 -0.6002574 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Other types of O-glycan biosynthesis -0.566956522 -0.645256917 -0.71969112 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Oxidative phosphorylation -0.774782609 -0.632411067 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Pantothenate and CoA biosynthesis 0 0.696640316 0.673616474 kegg kegg NA NA no no no no no dn Biosynthesis of amino acids Parabacteroides 0.480869565 0 0 kegg Genus NA 4.19E-05 no no no no up up Biosynthesis of amino acids Paraprevotella 0 -0.48656192 0 kegg Genus NA 0.118 no no no no no no Biosynthesis of amino acids Pentose and glucuronate interconversions 0 -0.638339921 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Pentose phosphate pathway 0.770434783 0.886363636 0.883655084 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Phenylalanine metabolism 0.446956522 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Porphyrin and chlorophyll metabolism 0 -0.419960474 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Primary bile acid biosynthesis 0 0 0.413384813 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Purine metabolism 0 -0.537549407 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Pyrimidine metabolism 0.610434783 -0.515810277 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Pyruvate metabolism 0 -0.468379447 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Retinol metabolism 0.537391304 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Ruminococcus -0.419130435 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Biosynthesis of amino acids Selenocompound metabolism 0 0 -0.503217503 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Starch and sucrose metabolism 0.653043478 0.692687747 0.450965251 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Steroid biosynthesis -0.41826087 0 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Sulfur metabolism 0 0 0.514543115 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Synthesis and degradation of ketone bodies 0 -0.458498024 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Taurine and hypotaurine metabolism 0 0 -0.511969112 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Terpenoid backbone biosynthesis 0 0 -0.467438867 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Tryptophan metabolism 0.567826087 0 0 kegg kegg NA NA no no no no up no Biosynthesis of amino acids Ubiquinone and other terpenoid-quinone biosynthesis 0 0 -0.416988417 kegg kegg NA NA no no no no no no Biosynthesis of amino acids "Valine, leucine and isoleucine degradation" 0 -0.467391304 0 kegg kegg NA NA no no no no no no Biosynthesis of amino acids Various types of N-glycan biosynthesis 0 -0.610671937 -0.474646075 kegg kegg NA NA no no no no no no Biosynthesis of cofactors 2-Oxocarboxylic acid metabolism 0.555652174 0 -0.413384813 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Amino sugar and nucleotide sugar metabolism 0.429565217 0.444664032 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Aminoacyl-tRNA biosynthesis 0.431304348 0.48715415 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Arachidonic acid metabolism 0.473043478 0 0.685199485 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Arginine and proline metabolism 0 -0.464426877 0 kegg kegg NA NA no no no no up no Biosynthesis of cofactors Ascorbate and aldarate metabolism 0 0 -0.425482625 kegg kegg NA NA no no no no no no Biosynthesis of cofactors beta-Alanine metabolism 0.453043478 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Biosynthesis of amino acids 0 -0.553359684 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Butanoate metabolism 0.613913043 0.527667984 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Citrate cycle (TCA cycle) 0.475652174 0.489130435 -0.427541828 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Cysteine and methionine metabolism 0 0.527667984 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Drug metabolism - cytochrome P450 0 0.515810277 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Ether lipid metabolism 0 0.699604743 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Fatty acid biosynthesis -0.460869565 -0.489130435 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Fructose and mannose metabolism 0.491304348 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Galactose metabolism 0 -0.446640316 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Glutathione metabolism 0.555652174 0.678853755 0.801801802 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Glycerolipid metabolism 0 0 -0.428314028 kegg kegg NA NA no no no no no up Biosynthesis of cofactors "Glycine, serine and threonine metabolism" 0.91826087 0.924901186 0.984813385 kegg kegg NA NA no no no no up no Biosynthesis of cofactors Glycolysis / Gluconeogenesis 0.475652174 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.451581028 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.47826087 0 -0.511711712 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Glycosaminoglycan degradation -0.410434783 -0.663043478 -0.579407979 kegg kegg NA NA no no no no no up Biosynthesis of cofactors Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.678853755 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Glyoxylate and dicarboxylate metabolism 0 -0.438735178 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors N-Glycan biosynthesis 0 0.550395257 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Nicotinate and nicotinamide metabolism -0.436521739 -0.576086957 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors One carbon pool by folate 0 0.718379447 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Other glycan degradation 0 0 -0.520720721 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Other types of O-glycan biosynthesis 0 0.445652174 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Pantothenate and CoA biosynthesis -0.540869565 -0.48715415 0 kegg kegg NA NA no no no no no dn Biosynthesis of cofactors Pentose and glucuronate interconversions 0.420869565 0.513833992 -0.445045045 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Pentose phosphate pathway 0 -0.675889328 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Phenylalanine metabolism 0.571304348 0 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Porphyrin and chlorophyll metabolism 0.871304348 0.875494071 0.980694981 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Propanoate metabolism 0 0.507905138 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Purine metabolism 0.595652174 0.87055336 0.546203346 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Pyrimidine metabolism 0 0.68083004 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Pyruvate metabolism 0.447826087 0.631422925 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Retinol metabolism 0 0.541501976 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Selenocompound metabolism 0 0.506916996 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Sphingolipid metabolism 0 0 -0.43037323 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Starch and sucrose metabolism 0 -0.48715415 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Steroid biosynthesis 0 0.498023715 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Steroid hormone biosynthesis 0 0.463438735 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Sulfur metabolism 0.626086957 0.653162055 0.744658945 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Synthesis and degradation of ketone bodies 0 0.7243083 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Terpenoid backbone biosynthesis 0 0.438735178 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Thiamine metabolism 0 0.712450593 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Tryptophan metabolism 0.465217391 0 0 kegg kegg NA NA no no no no up no Biosynthesis of cofactors Tyrosine metabolism 0.491304348 0.616600791 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Ubiquinone and other terpenoid-quinone biosynthesis 0.492173913 0.598814229 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors "Valine, leucine and isoleucine degradation" 0.526086957 0.544466403 0 kegg kegg NA NA no no no no no no Biosynthesis of cofactors Various types of N-glycan biosynthesis 0 0.469367589 -0.456885457 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids alpha-Linolenic acid metabolism 0.410434783 0 0.476447876 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Amino sugar and nucleotide sugar metabolism 0.640869565 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Aminoacyl-tRNA biosynthesis 0.68 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Ascorbate and aldarate metabolism 0.530434783 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids beta-Alanine metabolism 0.704347826 0.729249012 0.749034749 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Butanoate metabolism 0.617391304 0.614624506 0.656370656 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Citrate cycle (TCA cycle) 0.715652174 0.632411067 0.448648649 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Cysteine and methionine metabolism 0.586086957 0.599802372 0.444015444 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Drug metabolism - cytochrome P450 0.473913043 0.46541502 0.406177606 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Drug metabolism - other enzymes 0.524347826 0.428853755 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Ether lipid metabolism -0.406956522 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Fatty acid degradation 0.451304348 0 0.462033462 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Fatty acid elongation 0.795652174 0.802371542 0.814157014 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Galactose metabolism 0.526086957 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Glycolysis / Gluconeogenesis 0.63826087 0.497035573 0.545688546 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.477272727 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Glycosaminoglycan biosynthesis - keratan sulfate -0.532173913 -0.554347826 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Glycosphingolipid biosynthesis - lacto and neolacto series -0.525217391 0 -0.470785071 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Histidine metabolism 0.573913043 0.494071146 0.511711712 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Mannose type O-glycan biosynthesis -0.603478261 -0.453557312 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Metabolism of xenobiotics by cytochrome P450 0.514782609 0.531620553 0.438610039 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Mucin type O-glycan biosynthesis 0.571304348 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids One carbon pool by folate 0.68173913 0.436758893 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Pentose and glucuronate interconversions 0.688695652 0.444664032 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Phenylalanine metabolism 0.48173913 0.514822134 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Primary bile acid biosynthesis 0.896521739 0.833003953 0.84967825 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Propanoate metabolism 0.619130435 0.606719368 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Pyrimidine metabolism 0.653913043 0.48715415 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Pyruvate metabolism 0.692173913 0.520750988 0.464864865 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Retinol metabolism 0.805217391 0.711462451 0.54980695 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Sphingolipid metabolism -0.435652174 0 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Steroid biosynthesis 0 0.707509881 0.569111969 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Steroid hormone biosynthesis 0.705217391 0.671936759 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Sulfur metabolism 0 0.427865613 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Synthesis and degradation of ketone bodies 0.686086957 0.609683794 0.610553411 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Taurine and hypotaurine metabolism 0 -0.477272727 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Terpenoid backbone biosynthesis 0 0.497035573 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Thiamine metabolism 0.414782609 0.45256917 0 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Tryptophan metabolism 0.725217391 0.77173913 0.632689833 kegg kegg NA NA no no no no up no Biosynthesis of unsaturated fatty acids Tyrosine metabolism 0.743478261 0.637351779 0.707078507 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids Ubiquinone and other terpenoid-quinone biosynthesis 0.705217391 0.656126482 0.441184041 kegg kegg NA NA no no no no no no Biosynthesis of unsaturated fatty acids "Valine, leucine and isoleucine degradation" 0.733043478 0.602766798 0.74002574 kegg kegg NA NA no no no no no no Bladder cancer 2-Oxocarboxylic acid metabolism 0 -0.723320158 0 kegg kegg NA NA no no no no no no Bladder cancer Adherens junction 0 -0.562252964 0 kegg kegg NA NA no no no no no no Bladder cancer Adipocytokine signaling pathway 0 0.559288538 0 kegg kegg NA NA no no no no no no Bladder cancer Adrenergic signaling in cardiomyocytes 0 -0.575098814 -0.501673102 kegg kegg NA NA no no no no no up Bladder cancer African trypanosomiasis 0 0.565217391 0.422393822 kegg kegg NA NA no no no no no no Bladder cancer AGE-RAGE signaling pathway in diabetic complications 0 0.907114625 0 kegg kegg NA NA no no no no no no Bladder cancer "Alanine, aspartate and glutamate metabolism" 0.631304348 0.840909091 0.533590734 kegg kegg NA NA no no no no no no Bladder cancer Aldosterone synthesis and secretion -0.580869565 -0.591897233 -0.458687259 kegg kegg NA NA no no no no up up Bladder cancer Aldosterone-regulated sodium reabsorption 0 0.483201581 0 kegg kegg NA NA no no no no no no Bladder cancer alpha-Linolenic acid metabolism 0 0.571146245 0 kegg kegg NA NA no no no no no no Bladder cancer Alzheimer disease 0 -0.747035573 -0.518918919 kegg kegg NA NA no no no no no no Bladder cancer Aminoacyl-tRNA biosynthesis 0 -0.572134387 0 kegg kegg NA NA no no no no no no Bladder cancer Amoebiasis 0.450434783 0.914031621 0 kegg kegg NA NA no no no no no no Bladder cancer Amphetamine addiction -0.685217391 -0.714426877 -0.463320463 kegg kegg NA NA no no no no no no Bladder cancer AMPK signaling pathway -0.543478261 0 0 kegg kegg NA NA no no no no no no Bladder cancer Amyotrophic lateral sclerosis 0 -0.795454545 -0.536936937 kegg kegg NA NA no no no no no no Bladder cancer Apelin signaling pathway -0.42 -0.833003953 -0.485971686 kegg kegg NA NA no no no no no no Bladder cancer Apoptosis 0.553913043 0.831027668 0.587902188 kegg kegg NA NA no no no no no no Bladder cancer Arginine and proline metabolism 0.645217391 0.901185771 0.685714286 kegg kegg NA NA no no no no up no Bladder cancer Arginine biosynthesis 0.673043478 0.821146245 0.543886744 kegg kegg NA NA no no no no no no Bladder cancer Autophagy - animal 0.496521739 0.820158103 0 kegg kegg NA NA no no no no no no Bladder cancer B cell receptor signaling pathway 0.423478261 0.830039526 0.536936937 kegg kegg NA NA no no no no no no Bladder cancer Basal transcription factors 0 -0.561264822 -0.475160875 kegg kegg NA NA no no no no no no Bladder cancer Base excision repair 0 -0.431818182 -0.521235521 kegg kegg NA NA no no no no no no Bladder cancer Biosynthesis of amino acids 0.442608696 0.64229249 0.551866152 kegg kegg NA NA no no no no no no Bladder cancer Biosynthesis of cofactors -0.666956522 -0.572134387 0 kegg kegg NA NA no no no no no no Bladder cancer Butanoate metabolism 0 -0.847826087 -0.462805663 kegg kegg NA NA no no no no no no Bladder cancer C-type lectin receptor signaling pathway 0.544347826 0.806324111 0.515830116 kegg kegg NA NA no no no no no no Bladder cancer cAMP signaling pathway 0 0.528656126 0 yes kegg kegg NA NA no no no no up up Bladder cancer Carbohydrate digestion and absorption 0.416521739 0.551383399 0 kegg kegg NA NA no no no no no no Bladder cancer Carbon metabolism 0 0 0.461261261 kegg kegg NA NA no no no no no no Bladder cancer Cardiac muscle contraction 0 -0.726284585 -0.483140283 kegg kegg NA NA no no no no no up Bladder cancer Cell cycle -0.435652174 -0.71541502 -0.598712999 kegg kegg NA NA no no no no no no Bladder cancer Cellular senescence 0.433043478 0.548418972 0 kegg kegg NA NA no no no no no no Bladder cancer cGMP-PKG signaling pathway 0.62173913 0.786561265 0.608751609 kegg kegg NA NA no no no no no no Bladder cancer Chagas disease 0 0.846837945 0 kegg kegg NA NA no no no no no no Bladder cancer Chemical carcinogenesis - DNA adducts 0 0 0.616988417 kegg kegg NA NA no no no no no no Bladder cancer Chemokine signaling pathway 0.563478261 0.727272727 0.49034749 kegg kegg NA NA no no no no no no Bladder cancer Cholesterol metabolism 0 0 0.560875161 yes kegg kegg NA NA no no no no no up Bladder cancer Circadian entrainment -0.492173913 -0.463438735 0 kegg kegg NA NA no no no no up up Bladder cancer Circadian rhythm 0 -0.416996047 -0.419305019 kegg kegg NA NA no no no no no no Bladder cancer Citrate cycle (TCA cycle) 0 -0.845849802 0 kegg kegg NA NA no no no no no no Bladder cancer Cocaine addiction -0.534782609 0 0 kegg kegg NA NA no no no no no no Bladder cancer Complement and coagulation cascades 0.52 0.695652174 0.456113256 kegg kegg NA NA no no no no no no Bladder cancer Coronavirus disease - COVID-19 -0.519130435 -0.744071146 -0.412097812 kegg kegg NA NA no no no no no no Bladder cancer Cortisol synthesis and secretion -0.576521739 0 0 kegg kegg NA NA no no no no no up Bladder cancer Cushing syndrome -0.683478261 0 -0.408751609 kegg kegg NA NA no no no no no up Bladder cancer Cysteine and methionine metabolism 0 -0.862648221 -0.683140283 kegg kegg NA NA no no no no no no Bladder cancer Cytokine-cytokine receptor interaction 0.433043478 0 0 kegg kegg NA NA no no no no no no Bladder cancer DNA replication 0 -0.852766798 -0.483397683 kegg kegg NA NA no no no no no no Bladder cancer Dopaminergic synapse 0 -0.488142292 0 kegg kegg NA NA no no no no up no Bladder cancer Drug metabolism - cytochrome P450 0 -0.827075099 0 kegg kegg NA NA no no no no no no Bladder cancer Drug metabolism - other enzymes 0 -0.815217391 0 kegg kegg NA NA no no no no no no Bladder cancer ECM-receptor interaction -0.55826087 -0.447628458 -0.475675676 kegg kegg NA NA no no no no up up Bladder cancer EGFR tyrosine kinase inhibitor resistance 0 -0.729249012 -0.473101673 kegg kegg NA NA no no no no no no Bladder cancer Endocrine and other factor-regulated calcium reabsorption -0.560869565 -0.553359684 0 kegg kegg NA NA no no no no no no Bladder cancer Endocrine resistance -0.463478261 0 0 kegg kegg NA NA no no no no no no Bladder cancer Endocytosis 0.48 0.457509881 0 kegg kegg NA NA no no no no no no Bladder cancer Endometrial cancer 0 0.683794466 0 kegg kegg NA NA no no no no no no Bladder cancer Epithelial cell signaling in Helicobacter pylori infection 0.797391304 0.806324111 0.609009009 kegg kegg NA NA no no no no no no Bladder cancer ErbB signaling pathway 0 0.481225296 0 kegg kegg NA NA no no no no no no Bladder cancer Estrogen signaling pathway 0 -0.68972332 -0.479021879 kegg kegg NA NA no no no no no no Bladder cancer Ether lipid metabolism -0.422608696 -0.513833992 -0.413384813 kegg kegg NA NA no no no no no no Bladder cancer Fanconi anemia pathway 0 -0.424901186 -0.492149292 kegg kegg NA NA no no no no no no Bladder cancer Fat digestion and absorption 0.644347826 0.611660079 0.702445302 yes kegg kegg NA NA no no no no up up Bladder cancer Fatty acid biosynthesis 0.72 0.83201581 0.622651223 kegg kegg NA NA no no no no no no Bladder cancer Fatty acid degradation 0.532173913 0.542490119 0 kegg kegg NA NA no no no no no no Bladder cancer Fatty acid metabolism 0.472173913 0.524703557 0 kegg kegg NA NA no no no no no no Bladder cancer Fc epsilon RI signaling pathway 0.423478261 0.90513834 0.745173745 kegg kegg NA NA no no no no no no Bladder cancer Fc gamma R-mediated phagocytosis 0.728695652 0.619565217 0.62033462 kegg kegg NA NA no no no no no no Bladder cancer Focal adhesion 0 -0.587944664 0 kegg kegg NA NA no no no no up up Bladder cancer Folate biosynthesis 0 -0.565217391 0 kegg kegg NA NA no no no no no no Bladder cancer FoxO signaling pathway 0.417391304 0.538537549 0 kegg kegg NA NA no no no no no no Bladder cancer Fructose and mannose metabolism 0 0.53458498 0.437065637 kegg kegg NA NA no no no no no no Bladder cancer GABAergic synapse 0.582608696 0.718379447 0.465379665 kegg kegg NA NA no no no no up up Bladder cancer Galactose metabolism 0 0.529644269 0 kegg kegg NA NA no no no no no no Bladder cancer Gap junction -0.452173913 0 0 kegg kegg NA NA no no no no no no Bladder cancer Gastric acid secretion 0 -0.609683794 0 kegg kegg NA NA no no no no no no Bladder cancer Glucagon signaling pathway -0.66 -0.743083004 -0.604890605 kegg kegg NA NA no no no no no no Bladder cancer Glutamatergic synapse 0 0.532608696 0 kegg kegg NA NA no no no no up up Bladder cancer Glutathione metabolism -0.571304348 -0.612648221 0 kegg kegg NA NA no no no no no no Bladder cancer Glycerolipid metabolism 0 0.437747036 0 kegg kegg NA NA no no no no no up Bladder cancer "Glycine, serine and threonine metabolism" -0.673043478 -0.43083004 0 kegg kegg NA NA no no no no up no Bladder cancer Glycolysis / Gluconeogenesis 0 -0.713438735 0 kegg kegg NA NA no no no no no no Bladder cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.773913043 0.847826087 0.527927928 kegg kegg NA NA no no no no no no Bladder cancer Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.467391304 0 kegg kegg NA NA no no no no no no Bladder cancer Glycosaminoglycan degradation 0.596521739 0.503952569 0.418532819 kegg kegg NA NA no no no no no up Bladder cancer Glycosphingolipid biosynthesis - ganglio series 0 -0.455533597 0 kegg kegg NA NA no no no no no no Bladder cancer Glyoxylate and dicarboxylate metabolism 0.600869565 0.826086957 0.627027027 kegg kegg NA NA no no no no no no Bladder cancer GnRH secretion 0 0.539525692 0 kegg kegg NA NA no no no no up up Bladder cancer GnRH signaling pathway -0.494782609 0 0 kegg kegg NA NA no no no no no no Bladder cancer "Growth hormone synthesis, secretion and action" 0 0.48715415 0 kegg kegg NA NA no no no no no no Bladder cancer Hedgehog signaling pathway 0 -0.489130435 0 kegg kegg NA NA no no no no no no Bladder cancer Hematopoietic cell lineage 0 -0.442687747 0 kegg kegg NA NA no no no no no no Bladder cancer Hepatitis B 0.556521739 0.850790514 0.410810811 kegg kegg NA NA no no no no no no Bladder cancer Hepatitis C 0 0.434782609 0 kegg kegg NA NA no no no no no no Bladder cancer HIF-1 signaling pathway 0 -0.719367589 0 kegg kegg NA NA no no no no no no Bladder cancer Hippo signaling pathway 0 -0.686758893 0 kegg kegg NA NA no no no no no no Bladder cancer Hippo signaling pathway - multiple species 0.585217391 0.772727273 0.592020592 kegg kegg NA NA no no no no no no Bladder cancer Homologous recombination 0 0 -0.596396396 kegg kegg NA NA no no no no no no Bladder cancer Human papillomavirus infection 0.417391304 0.572134387 0 kegg kegg NA NA no no no no no no Bladder cancer Huntington disease 0 -0.744071146 -0.508880309 kegg kegg NA NA no no no no no no Bladder cancer IL-17 signaling pathway 0.815652174 0.736166008 0.743886744 kegg kegg NA NA no no no no no no Bladder cancer Inflammatory mediator regulation of TRP channels -0.474782609 -0.717391304 -0.503474903 kegg kegg NA NA no no no no no no Bladder cancer Insulin resistance 0 0.742094862 0 kegg kegg NA NA no no no no no no Bladder cancer Insulin secretion -0.666086957 0 0 yes kegg kegg NA NA no no no no up up Bladder cancer Insulin signaling pathway 0 -0.796442688 -0.44041184 kegg kegg NA NA no no no no no no Bladder cancer JAK-STAT signaling pathway 0 0.697628458 0 kegg kegg NA NA no no no no no no Bladder cancer Legionellosis 0 -0.460474308 0 kegg kegg NA NA no no no no no no Bladder cancer Leishmaniasis 0 -0.445652174 0 kegg kegg NA NA no no no no no no Bladder cancer Long-term potentiation 0 -0.681818182 0 kegg kegg NA NA no no no no no up Bladder cancer Lysosome 0.706086957 0.532608696 0.78043758 kegg kegg NA NA no no no no no no Bladder cancer Melanogenesis -0.666956522 -0.692687747 -0.533075933 kegg kegg NA NA no no no no no no Bladder cancer Melanoma 0.439130435 0.770750988 0 kegg kegg NA NA no no no no no no Bladder cancer Metabolism of xenobiotics by cytochrome P450 0 -0.790513834 0 kegg kegg NA NA no no no no no no Bladder cancer MicroRNAs in cancer 0 0.804347826 0 kegg kegg NA NA no no no no no no Bladder cancer Mismatch repair 0 -0.698616601 -0.483140283 kegg kegg NA NA no no no no no no Bladder cancer Mitophagy - animal -0.507826087 -0.488142292 0 kegg kegg NA NA no no no no no no Bladder cancer Morphine addiction -0.41826087 0 0 kegg kegg NA NA no no no no up up Bladder cancer mRNA surveillance pathway 0 -0.65513834 -0.525096525 kegg kegg NA NA no no no no no no Bladder cancer mTOR signaling pathway 0 -0.718379447 -0.419305019 kegg kegg NA NA no no no no no no Bladder cancer N-Glycan biosynthesis -0.592173913 -0.853754941 -0.522265122 kegg kegg NA NA no no no no no no Bladder cancer Natural killer cell mediated cytotoxicity 0.442608696 0.466403162 0 kegg kegg NA NA no no no no no no Bladder cancer Neuroactive ligand-receptor interaction 0.473913043 0.462450593 0.694723295 kegg kegg NA NA no no no up up up Bladder cancer Neurotrophin signaling pathway 0 0.636363636 0 kegg kegg NA NA no no no no no no Bladder cancer Neutrophil extracellular trap formation 0.700869565 0.640316206 0.652509653 kegg kegg NA NA no no no no no no Bladder cancer NF-kappa B signaling pathway 0.536521739 0.863636364 0.446589447 kegg kegg NA NA no no no no no no Bladder cancer Nicotinate and nicotinamide metabolism 0.826956522 0.914031621 0.825482625 kegg kegg NA NA no no no no no no Bladder cancer Nitrogen metabolism 0.632173913 0.822134387 0.477734878 kegg kegg NA NA no no no no no no Bladder cancer NOD-like receptor signaling pathway 0.896521739 0.803359684 0.412355212 kegg kegg NA NA no no no no no no Bladder cancer Non-alcoholic fatty liver disease 0 -0.626482213 -0.520720721 kegg kegg NA NA no no no no no no Bladder cancer Non-homologous end-joining 0 -0.556324111 0 kegg kegg NA NA no no no no no no Bladder cancer Notch signaling pathway 0 0.486166008 0 kegg kegg NA NA no no no no no no Bladder cancer Nucleotide excision repair 0 -0.740118577 -0.615701416 kegg kegg NA NA no no no no no no Bladder cancer Olfactory transduction 0.599130435 0.601778656 0.626769627 kegg kegg NA NA no no no no no no Bladder cancer One carbon pool by folate -0.48173913 -0.712450593 -0.519433719 kegg kegg NA NA no no no no no no Bladder cancer Oocyte meiosis 0 -0.780632411 -0.509137709 kegg kegg NA NA no no no no no no Bladder cancer Osteoclast differentiation 0.824347826 0.799407115 0.802316602 kegg kegg NA NA no no no no no no Bladder cancer Ovarian steroidogenesis -0.590434783 0 0 kegg kegg NA NA no no no no up up Bladder cancer Oxidative phosphorylation 0 -0.733201581 -0.457400257 kegg kegg NA NA no no no no no no Bladder cancer p53 signaling pathway 0 0 -0.456113256 kegg kegg NA NA no no no no no no Bladder cancer Pancreatic secretion -0.409565217 -0.447628458 0 kegg kegg NA NA no no no no no no Bladder cancer Pantothenate and CoA biosynthesis 0.786086957 0.786561265 0.598970399 kegg kegg NA NA no no no no no dn Bladder cancer "Parathyroid hormone synthesis, secretion and action" 0 -0.45256917 -0.444787645 kegg kegg NA NA no no no no no no Bladder cancer Parkinson disease -0.464347826 -0.661067194 -0.425225225 kegg kegg NA NA no no no no no no Bladder cancer Pathogenic Escherichia coli infection 0.599130435 0.445652174 0.463063063 kegg kegg NA NA no no no no no no Bladder cancer Pathways in cancer 0 0.56916996 0 kegg kegg NA NA no no no no no no Bladder cancer Pathways of neurodegeneration - multiple diseases -0.484347826 -0.669960474 -0.424453024 kegg kegg NA NA no no no no no no Bladder cancer Pentose and glucuronate interconversions 0 -0.889328063 -0.403861004 kegg kegg NA NA no no no no no no Bladder cancer Pentose phosphate pathway 0.610434783 0.639328063 0.663835264 kegg kegg NA NA no no no no no no Bladder cancer Peroxisome 0.6 0.636363636 0.433719434 kegg kegg NA NA no no no no no no Bladder cancer Pertussis 0.746956522 0.705533597 0.673873874 kegg kegg NA NA no no no no no dn Bladder cancer Phagosome 0.410434783 0.454545455 0.448648649 kegg kegg NA NA no no no no no no Bladder cancer Phenylalanine metabolism 0 -0.696640316 0 kegg kegg NA NA no no no no no no Bladder cancer Phospholipase D signaling pathway 0 0.865612648 0.408751609 kegg kegg NA NA no no no no up up Bladder cancer Phototransduction 0 -0.650197628 -0.541827542 kegg kegg NA NA no no no no no no Bladder cancer PI3K-Akt signaling pathway 0 0 -0.537451737 yes kegg kegg NA NA no no no no up up Bladder cancer Porphyrin and chlorophyll metabolism -0.600869565 0 0 kegg kegg NA NA no no no no no no Bladder cancer PPAR signaling pathway 0.722608696 0.719367589 0.612355212 kegg kegg NA NA no no no no no no Bladder cancer Primary bile acid biosynthesis 0 -0.488142292 0 kegg kegg NA NA no no no no no no Bladder cancer Prion disease 0 -0.815217391 -0.476190476 kegg kegg NA NA no no no no no no Bladder cancer Prolactin signaling pathway 0.434782609 0.758893281 0.421621622 kegg kegg NA NA no no no no no no Bladder cancer Propanoate metabolism 0 -0.816205534 -0.586100386 kegg kegg NA NA no no no no no no Bladder cancer Prostate cancer 0 0.663043478 0 kegg kegg NA NA no no no no no no Bladder cancer Proteasome 0 -0.749011858 0 kegg kegg NA NA no no no no no no Bladder cancer Protein digestion and absorption 0 0.584980237 0.401801802 yes kegg kegg NA NA no no no no up up Bladder cancer Protein export -0.485217391 -0.830039526 -0.485199485 kegg kegg NA NA no no no no no no Bladder cancer Protein processing in endoplasmic reticulum -0.739130435 -0.826086957 -0.571171171 kegg kegg NA NA no no no no no no Bladder cancer Proteoglycans in cancer 0 -0.774703557 0 kegg kegg NA NA no no no no no no Bladder cancer Proximal tubule bicarbonate reclamation -0.432173913 -0.773715415 -0.417245817 kegg kegg NA NA no no no no no no Bladder cancer Purine metabolism -0.50173913 -0.449604743 0 kegg kegg NA NA no no no no no no Bladder cancer Pyrimidine metabolism 0 -0.650197628 0 kegg kegg NA NA no no no no no no Bladder cancer Pyruvate metabolism 0 -0.896245059 -0.593822394 kegg kegg NA NA no no no no no no Bladder cancer Ras signaling pathway 0 -0.68972332 0 yes kegg kegg NA NA no no no no up up Bladder cancer Regulation of actin cytoskeleton 0 -0.497035573 0 kegg kegg NA NA no no no no no no Bladder cancer Relaxin signaling pathway 0 0.658102767 0 kegg kegg NA NA no no no no no no Bladder cancer Renin secretion -0.607826087 -0.707509881 -0.438095238 kegg kegg NA NA no no no no no no Bladder cancer Renin-angiotensin system 0.633913043 0.640316206 0.529214929 kegg kegg NA NA no no no no no no Bladder cancer Retinol metabolism 0 -0.515810277 0 kegg kegg NA NA no no no no no no Bladder cancer Retrograde endocannabinoid signaling 0 -0.714426877 0 kegg kegg NA NA no no no no no up Bladder cancer Ribosome -0.528695652 -0.752964427 -0.416988417 kegg kegg NA NA no no no no no no Bladder cancer Ribosome biogenesis in eukaryotes -0.477391304 -0.697628458 -0.531016731 kegg kegg NA NA no no no no no no Bladder cancer RIG-I-like receptor signaling pathway 0.579130435 0.852766798 0.427541828 kegg kegg NA NA no no no no no no Bladder cancer RNA degradation 0 -0.807312253 -0.475160875 kegg kegg NA NA no no no no no no Bladder cancer RNA polymerase -0.462608696 -0.813241107 -0.539253539 kegg kegg NA NA no no no no no no Bladder cancer RNA transport 0 -0.711462451 -0.503989704 kegg kegg NA NA no no no no no no Bladder cancer Salmonella infection 0.562608696 0 0 kegg kegg NA NA no no no no no no Bladder cancer Shigellosis 0 -0.440711462 0 kegg kegg NA NA no no no no no no Bladder cancer SNARE interactions in vesicular transport 0 0.556324111 0 kegg kegg NA NA no no no no no no Bladder cancer Sphingolipid metabolism 0.517391304 0 0.402059202 kegg kegg NA NA no no no no no no Bladder cancer Sphingolipid signaling pathway 0.439130435 0.458498024 0 kegg kegg NA NA no no no no no no Bladder cancer Spinocerebellar ataxia 0 -0.587944664 0 kegg kegg NA NA no no no no no no Bladder cancer Spliceosome 0 0 -0.47979408 kegg kegg NA NA no no no no no no Bladder cancer Staphylococcus aureus infection 0.454782609 0.442687747 0.510939511 kegg kegg NA NA no no no up no no Bladder cancer Starch and sucrose metabolism 0.58173913 0.77173913 0.576833977 kegg kegg NA NA no no no no no no Bladder cancer Steroid biosynthesis -0.527826087 -0.615612648 0 kegg kegg NA NA no no no no no no Bladder cancer Steroid hormone biosynthesis 0 -0.517786561 0 kegg kegg NA NA no no no no no no Bladder cancer Synaptic vesicle cycle 0.608695652 0.60770751 0.654568855 kegg kegg NA NA no no no no up up Bladder cancer Synthesis and degradation of ketone bodies 0 -0.700592885 0 kegg kegg NA NA no no no no no no Bladder cancer Taste transduction 0 -0.630434783 0 kegg kegg NA NA no no no no no up Bladder cancer Taurine and hypotaurine metabolism 0 0.447628458 0 kegg kegg NA NA no no no no no no Bladder cancer Terpenoid backbone biosynthesis 0 -0.441699605 0 kegg kegg NA NA no no no no no no Bladder cancer TGF-beta signaling pathway 0 -0.773715415 0 kegg kegg NA NA no no no no no no Bladder cancer Thermogenesis 0 -0.805335968 -0.527927928 kegg kegg NA NA no no no no no no Bladder cancer Thiamine metabolism 0 -0.699604743 0 kegg kegg NA NA no no no no no no Bladder cancer Thyroid cancer 0 0 -0.465637066 kegg kegg NA NA no no no no no no Bladder cancer Thyroid hormone signaling pathway 0 -0.491106719 0 kegg kegg NA NA no no no no no no Bladder cancer Thyroid hormone synthesis -0.78173913 0 0 kegg kegg NA NA no no no no no no Bladder cancer Tight junction 0 -0.46541502 0 kegg kegg NA NA no no no no no no Bladder cancer TNF signaling pathway 0 0.776679842 0.435778636 kegg kegg NA NA no no no no no no Bladder cancer Toll-like receptor signaling pathway 0.659130435 0.895256917 0.625482625 yes kegg kegg NA NA no no no no no no Bladder cancer Transcriptional misregulation in cancer 0.469565217 0.805335968 0 kegg kegg NA NA no no no no no no Bladder cancer Tryptophan metabolism 0 -0.598814229 0 kegg kegg NA NA no no no no up no Bladder cancer Tuberculosis 0.619130435 0.563241107 0.58970399 kegg kegg NA NA no no no no no dn Bladder cancer Type II diabetes mellitus 0.41826087 0.679841897 0 kegg kegg NA NA no no no no no no Bladder cancer Tyrosine metabolism 0 -0.726284585 0 kegg kegg NA NA no no no no no no Bladder cancer Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.625494071 -0.516602317 kegg kegg NA NA no no no no no no Bladder cancer Ubiquitin mediated proteolysis -0.628695652 -0.587944664 0 kegg kegg NA NA no no no no no no Bladder cancer "Valine, leucine and isoleucine degradation" 0 -0.752964427 0 kegg kegg NA NA no no no no no no Bladder cancer Various types of N-glycan biosynthesis 0 -0.719367589 0 kegg kegg NA NA no no no no no no Bladder cancer Vascular smooth muscle contraction -0.466956522 -0.596837945 0 kegg kegg NA NA no no no no no no Bladder cancer Vasopressin-regulated water reabsorption -0.580869565 -0.505928854 -0.417503218 kegg kegg NA NA no no no no no no Bladder cancer VEGF signaling pathway 0 0.626482213 0 kegg kegg NA NA no no no no no no Bladder cancer Vibrio cholerae infection 0 -0.435770751 0 kegg kegg NA NA no no no no no no Bladder cancer Viral carcinogenesis 0 0.598814229 0 kegg kegg NA NA no no no no no no Bladder cancer Wnt signaling pathway 0 -0.82312253 0 kegg kegg NA NA no no no no no no Bladder cancer Yersinia infection 0.594782609 0.529644269 0 kegg kegg NA NA no no no no no no Blautia Bacteroides 0.662820707 0 0 acetate-producing LPS-producing Genus Genus 1.36E-05 0.000267 up dn dn dn dn up BMI+clinic 14:0+blood 0 0 -0.414615385 yes yes clinic serum_fattyacid 0.00527 0.00572 no up no up no dn BMI+clinic 16:1+blood 0 -0.821428571 0 yes yes clinic serum_fattyacid 0.00527 0.0186 no up no no no dn BMI+clinic 18:0/18:0-PS+blood 0 -0.582142857 0 yes clinic serum_phospholipids 0.00527 0.00617 no up no no up no BMI+clinic 18:0/20:3-PI+blood 0 0 -0.41 yes clinic serum_phospholipids 0.00527 0.377 no up no no no no BMI+clinic 18:0/22:6-PE+blood 0 -0.55 0 yes clinic serum_phospholipids 0.00527 0.00022 no up no up up no BMI+clinic 18:2-LPE+blood 0 0 0.504615385 yes clinic serum_phospholipids 0.00527 0.112 no up no no no no BMI+clinic 18:3n6+blood 0 -0.603571429 0 yes clinic serum_fattyacid 0.00527 0.0463 no up no up no dn BMI+clinic 20:4-LPA+blood 0 0.653571429 0 yes clinic serum_phospholipids 0.00527 0.398 no up no no no no BMI+clinic 20:4/18:0-PE+blood 0 -0.514285714 0 yes clinic serum_phospholipids 0.00527 0.000755 no up no up up no BMI+clinic 22:6n3+blood 0 0 -0.436923077 yes clinic serum_fattyacid 0.00527 0.792 no up no no no no BMI+clinic Adipocytokine signaling pathway -0.471485037 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Adrenergic signaling in cardiomyocytes -0.446640316 0 0.449859944 yes clinic kegg 0.00527 NA no up no no no up BMI+clinic Akkermansia 0 0 -0.460717645 yes acetate-producing clinic Genus 0.00527 0.23 no up no no no no BMI+clinic Aldosterone synthesis and secretion -0.465838509 0 0 yes clinic kegg 0.00527 NA no up no no up up BMI+clinic Alzheimer disease -0.434217956 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Amyotrophic lateral sclerosis -0.485036702 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic C-peptide -0.458498024 0 0 yes clinic DM-assocaited hormones 0.00527 0.228 no up no no no no BMI+clinic Calcium signaling pathway -0.465838509 0 0 yes clinic kegg 0.00527 NA no up no no up up BMI+clinic cAMP signaling pathway -0.477131564 0 0 yes yes clinic kegg 0.00527 NA no up no no up up BMI+clinic Carbon metabolism 0 0 -0.421848739 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Cardiac muscle contraction -0.470355731 0 0 yes clinic kegg 0.00527 NA no up no no no up BMI+clinic Choline+blood -0.486068111 0 0 yes clinic serum_choline 0.00527 0.0395 no up no no up no BMI+clinic Cholinergic synapse 0 0 0.43557423 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Circadian entrainment 0 -0.520779221 0 yes clinic kegg 0.00527 NA no up no no up up BMI+clinic Cushing syndrome -0.445511011 0 0 yes clinic kegg 0.00527 NA no up no no no up BMI+clinic d18:1-18:0-SM+blood 0 0 0.439230769 yes clinic serum_phospholipids 0.00527 0.97 no up no no no no BMI+clinic d18:1-20:1-SM+blood 0 0 0.416923077 yes clinic serum_phospholipids 0.00527 0.0992 no up no no no no BMI+clinic d18:1-24:1-SM+blood 0.558307534 0 0 yes clinic serum_phospholipids 0.00527 0.0123 no up no no dn dn BMI+clinic Diabetic cardiomyopathy -0.46809712 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Eotaxin 0 0.507017544 0 yes clinic serum_cytokines 0.00527 0.393 no up no no no no BMI+clinic Faecalibacterium 0 -0.4432524 0 yes butyrate-producing clinic Genus 0.00527 0.0039 no up no no dn dn BMI+clinic Glycolysis / Gluconeogenesis 0 0 -0.437535014 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic GnRH signaling pathway -0.447769622 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic GPC+blood 0 0.514285714 0 yes clinic serum_choline 0.00527 0.00427 no up no no up up BMI+clinic Hepatitis C 0 0.458441558 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Huntington disease -0.422924901 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Inflammatory mediator regulation of TRP channels 0 -0.498701299 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic IP-10 0.648351648 0 0 yes clinic serum_cytokines 0.00527 0.394 no up no no no no BMI+clinic Kaposi sarcoma-associated herpesvirus infection -0.571993224 0 0 yes clinic kegg 0.00527 NA no up no no no dn BMI+clinic L-Glutamine+blood 0 0.528571429 0 yes clinic serum_aminoacids 0.00527 0.639 no up no no no no BMI+clinic L-Isoleucine+blood 0 0 -0.413846154 yes yes clinic serum_aminoacids 0.00527 5.47E-06 no up no up up no BMI+clinic L-Phenylalanine+stool 0 0.718181818 -0.436476567 yes clinic stool_cometabolism 0.00527 0.398 no up no no no no BMI+clinic L-Proline+blood 0 0 0.41 yes yes clinic serum_aminoacids 0.00527 0.00265 no up no up up no BMI+clinic L-Tryptophan+stool 0 0 -0.464709204 yes clinic stool_cometabolism 0.00527 0.557 no up no no no no BMI+clinic Long-term depression -0.513269339 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Long-term potentiation 0 0 0.546218487 yes clinic kegg 0.00527 NA no up no no no up BMI+clinic Longevity regulating pathway - multiple species 0.429700734 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Measles 0 0.683116883 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Methanobrevibacter 0 0.446959858 0 yes clinic Genus 0.00527 0.629 no up no no no no BMI+clinic Mineral absorption -0.427442123 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic MIP-1b 0 0 0.442364532 yes clinic serum_cytokines 0.00527 0.632 no up no no no no BMI+clinic Mitophagy - animal -0.472614342 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Morphine addiction -0.447769622 -0.466233766 0 yes clinic kegg 0.00527 NA no up no no up up BMI+clinic Non-alcoholic fatty liver disease -0.472614342 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Odoribacter 0.42542348 0 0 yes butyrate-producing clinic Genus 0.00527 0.798 no up no no no no BMI+clinic Oocyte meiosis 0 0 0.427170868 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Oscillospira 0 0.488424619 0 yes LPS-producing clinic Genus 0.00527 0.62 no up no no no no BMI+clinic Oxidative phosphorylation -0.438735178 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Pancreatic secretion -0.548277809 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Parabacteroides 0 0.451157538 0 yes clinic Genus 0.00527 4.19E-05 no up no no up up BMI+clinic Paraprevotella 0 -0.526103361 0 yes clinic Genus 0.00527 0.118 no up no no no no BMI+clinic "Parathyroid hormone synthesis, secretion and action" -0.494071146 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Parkinson disease -0.520045172 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Pathways of neurodegeneration - multiple diseases -0.532467532 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Peroxisome 0.431959345 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Phenylacetic acid+stool 0 0 -0.476002259 yes clinic stool_cometabolism 0.00527 0.785 no up no no no no BMI+clinic Primary immunodeficiency 0.602484472 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic PUFA+blood 0 0 -0.516153846 yes clinic serum_fattyacid 0.00527 0.212 no up no no no no BMI+clinic RANTES 0.659340659 0 0 yes yes clinic serum_cytokines 0.00527 0.0757 no up no no no up BMI+clinic Relaxin signaling pathway -0.447769622 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Renin secretion 0 -0.450649351 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Roseburia 0 -0.44224797 0 yes butyrate-producing clinic Genus 0.00527 0.495 no up no no no no BMI+clinic Salivary secretion 0 -0.487012987 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Salmonella infection 0 0.433766234 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic T cell receptor signaling pathway 0 0.44025974 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Taurine+blood 0 0.575 0 yes clinic serum_aminoacids 0.00527 0.857 no up no no no no BMI+clinic Th1 and Th2 cell differentiation 0 0.449350649 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Th17 cell differentiation 0 0.541558442 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Thermogenesis -0.427442123 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic ToFA+blood 0 0 -0.403846154 yes clinic serum_fattyacid 0.00527 0.0307 no up no up no dn BMI+clinic Toxoplasmosis 0.436476567 0.487012987 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic Ubiquitin mediated proteolysis -0.456804065 0 0 yes clinic kegg 0.00527 NA no up no no no no BMI+clinic UFA+blood 0 0 -0.403076923 yes clinic serum_fattyacid 0.00527 0.0444 no up no up no dn BMI+clinic Visfatin 0.499011858 0 0 yes clinic DM-assocaited hormones 0.00527 0.0229 no up no dn no up Breast cancer 2-Oxocarboxylic acid metabolism -0.586956522 -0.451581028 0 kegg kegg NA NA no no no no no no Breast cancer ABC transporters 0 0.621541502 0 kegg kegg NA NA no no no no up up Breast cancer Acute myeloid leukemia 0.640869565 0.65513834 0.611840412 kegg kegg NA NA no no no no no no Breast cancer Adherens junction -0.417391304 -0.733201581 0 kegg kegg NA NA no no no no no no Breast cancer Adipocytokine signaling pathway 0 0.541501976 0 kegg kegg NA NA no no no no no no Breast cancer Adrenergic signaling in cardiomyocytes 0 -0.460474308 0 kegg kegg NA NA no no no no no up Breast cancer African trypanosomiasis 0.524347826 0.444664032 0 kegg kegg NA NA no no no no no no Breast cancer AGE-RAGE signaling pathway in diabetic complications 0.509565217 0.706521739 0.609266409 kegg kegg NA NA no no no no no no Breast cancer Akkermansia 0 -0.533553267 0 acetate-producing kegg Genus NA 0.23 no no no no no no Breast cancer "Alanine, aspartate and glutamate metabolism" 0 0.632411067 0 kegg kegg NA NA no no no no no no Breast cancer Aldosterone-regulated sodium reabsorption 0.756521739 0.491106719 0.675675676 kegg kegg NA NA no no no no no no Breast cancer alpha-Linolenic acid metabolism -0.414782609 0.471343874 0 kegg kegg NA NA no no no no no no Breast cancer Alzheimer disease 0 -0.656126482 0 kegg kegg NA NA no no no no no no Breast cancer Amino sugar and nucleotide sugar metabolism -0.520869565 0 0 kegg kegg NA NA no no no no no no Breast cancer Amoebiasis 0 0.489130435 0 kegg kegg NA NA no no no no no no Breast cancer Amyotrophic lateral sclerosis 0 -0.650197628 0 kegg kegg NA NA no no no no no no Breast cancer Antigen processing and presentation 0 -0.46541502 -0.492664093 kegg kegg NA NA no no no no no no Breast cancer Apelin signaling pathway 0 -0.695652174 0 kegg kegg NA NA no no no no no no Breast cancer Apoptosis 0 0.514822134 0 kegg kegg NA NA no no no no no no Breast cancer Apoptosis - multiple species 0 0.593873518 0 kegg kegg NA NA no no no no no no Breast cancer Arachidonic acid metabolism -0.662608696 0 -0.521750322 kegg kegg NA NA no no no no no no Breast cancer Arginine and proline metabolism 0 0.558300395 0 kegg kegg NA NA no no no no up no Breast cancer Arginine biosynthesis 0 0.545454545 0 kegg kegg NA NA no no no no no no Breast cancer Ascorbate and aldarate metabolism -0.429565217 -0.45256917 0 kegg kegg NA NA no no no no no no Breast cancer Autophagy - animal 0.696521739 0.855731225 0.671299871 kegg kegg NA NA no no no no no no Breast cancer Autophagy - other 0.52 0.570158103 0.638095238 kegg kegg NA NA no no no no no no Breast cancer B cell receptor signaling pathway 0.509565217 0.634387352 0.411325611 kegg kegg NA NA no no no no no no Breast cancer Bacterial invasion of epithelial cells -0.433043478 -0.709486166 0 kegg kegg NA NA no no no no no no Breast cancer Basal cell carcinoma 0.426086957 0 0.628056628 kegg kegg NA NA no no no no no no Breast cancer beta-Alanine metabolism -0.668695652 -0.508893281 0 kegg kegg NA NA no no no no no no Breast cancer Bifidobacterium 0 -0.491829146 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Breast cancer Biosynthesis of amino acids -0.457391304 0 0 kegg kegg NA NA no no no no no no Breast cancer Biosynthesis of cofactors -0.529565217 0 0 kegg kegg NA NA no no no no no no Breast cancer Biosynthesis of unsaturated fatty acids -0.543478261 -0.41798419 0 kegg kegg NA NA no no no no no no Breast cancer Bladder cancer 0 0.683794466 0 kegg kegg NA NA no no no no no no Breast cancer Butanoate metabolism -0.605217391 -0.600790514 -0.415444015 kegg kegg NA NA no no no no no no Breast cancer C-type lectin receptor signaling pathway 0.720869565 0.657114625 0.535135135 kegg kegg NA NA no no no no no no Breast cancer cAMP signaling pathway 0.57826087 0 0 yes kegg kegg NA NA no no no no up up Breast cancer Carbohydrate digestion and absorption 0.820869565 0.774703557 0.788159588 kegg kegg NA NA no no no no no no Breast cancer Carbon metabolism -0.64 -0.416007905 0 kegg kegg NA NA no no no no no no Breast cancer Cardiac muscle contraction 0 -0.617588933 0 kegg kegg NA NA no no no no no up Breast cancer cGMP-PKG signaling pathway 0.506086957 0 0 kegg kegg NA NA no no no no no no Breast cancer Chagas disease 0.619130435 0.665019763 0 kegg kegg NA NA no no no no no no Breast cancer Chemical carcinogenesis - DNA adducts -0.510434783 0 0 kegg kegg NA NA no no no no no no Breast cancer Chemical carcinogenesis - receptor activation 0.485217391 0 0 kegg kegg NA NA no no no no no no Breast cancer Cholinergic synapse 0.759130435 0 0.688803089 kegg kegg NA NA no no no no no no Breast cancer Chronic myeloid leukemia 0.670434783 0.636363636 0.587387387 kegg kegg NA NA no no no no no no Breast cancer Circadian entrainment 0 -0.554347826 -0.46048906 kegg kegg NA NA no no no no up up Breast cancer Circadian rhythm 0.586956522 0 0.544916345 kegg kegg NA NA no no no no no no Breast cancer Citrate cycle (TCA cycle) -0.577391304 -0.684782609 0 kegg kegg NA NA no no no no no no Breast cancer Clostridium 0 -0.544042123 0 kegg Genus NA 0.925 no no no no no no Breast cancer Collecting duct acid secretion 0 0 -0.423166023 kegg kegg NA NA no no no no no no Breast cancer Collinsella 0 0 -0.512585492 kegg Genus NA 0.128 no no no no no no Breast cancer Colorectal cancer 0.75826087 0.494071146 0.866151866 kegg kegg NA NA no no no no no no Breast cancer Coronavirus disease - COVID-19 0 -0.664031621 -0.418018018 kegg kegg NA NA no no no no no no Breast cancer Cysteine and methionine metabolism 0 -0.662055336 0 kegg kegg NA NA no no no no no no Breast cancer Cytokine-cytokine receptor interaction 0 0 -0.483397683 kegg kegg NA NA no no no no no no Breast cancer DNA replication 0 -0.52173913 0 kegg kegg NA NA no no no no no no Breast cancer Dopaminergic synapse 0 -0.508893281 0 kegg kegg NA NA no no no no up no Breast cancer Drug metabolism - cytochrome P450 -0.645217391 -0.739130435 -0.404118404 kegg kegg NA NA no no no no no no Breast cancer Drug metabolism - other enzymes -0.740869565 -0.769762846 0 kegg kegg NA NA no no no no no no Breast cancer EGFR tyrosine kinase inhibitor resistance 0 -0.537549407 0 kegg kegg NA NA no no no no no no Breast cancer Endocrine and other factor-regulated calcium reabsorption 0 -0.480237154 0 kegg kegg NA NA no no no no no no Breast cancer Endocrine resistance 0.409565217 0 0 kegg kegg NA NA no no no no no no Breast cancer Endometrial cancer 0.809565217 0.801383399 0.891891892 kegg kegg NA NA no no no no no no Breast cancer Epithelial cell signaling in Helicobacter pylori infection 0 0.424901186 0 kegg kegg NA NA no no no no no no Breast cancer ErbB signaling pathway 0.825217391 0.81027668 0.902187902 kegg kegg NA NA no no no no no no Breast cancer Estrogen signaling pathway 0 -0.449604743 0 kegg kegg NA NA no no no no no no Breast cancer Fatty acid biosynthesis 0 0.658102767 0 kegg kegg NA NA no no no no no no Breast cancer Fatty acid degradation 0 0.529644269 0 kegg kegg NA NA no no no no no no Breast cancer Fatty acid elongation -0.677391304 -0.552371542 -0.49034749 kegg kegg NA NA no no no no no no Breast cancer Fc epsilon RI signaling pathway 0.684347826 0.675889328 0.4998713 kegg kegg NA NA no no no no no no Breast cancer Ferroptosis 0 0 -0.46048906 kegg kegg NA NA no no no no no no Breast cancer Focal adhesion -0.406956522 -0.778656126 0 kegg kegg NA NA no no no no up up Breast cancer FoxO signaling pathway 0.493043478 0.809288538 0 kegg kegg NA NA no no no no no no Breast cancer Fructose and mannose metabolism -0.406956522 0.654150198 0 kegg kegg NA NA no no no no no no Breast cancer GABAergic synapse 0 0.442687747 0 kegg kegg NA NA no no no no up up Breast cancer Galactose metabolism 0 0.576086957 0 kegg kegg NA NA no no no no no no Breast cancer Gastric acid secretion -0.411304348 -0.752964427 0 kegg kegg NA NA no no no no no no Breast cancer Glioma 0.602608696 0 0.603346203 kegg kegg NA NA no no no no no no Breast cancer Glucagon signaling pathway 0 -0.431818182 0 kegg kegg NA NA no no no no no no Breast cancer Glutathione metabolism -0.566086957 -0.540513834 -0.562162162 kegg kegg NA NA no no no no no no Breast cancer Glycerolipid metabolism 0 0.718379447 0.545688546 kegg kegg NA NA no no no no no up Breast cancer Glycerophospholipid metabolism 0.451304348 0.617588933 0.506563707 kegg kegg NA NA no no no no no up Breast cancer "Glycine, serine and threonine metabolism" -0.429565217 0 0 kegg kegg NA NA no no no no up no Breast cancer Glycolysis / Gluconeogenesis -0.666086957 -0.745059289 0 kegg kegg NA NA no no no no no no Breast cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.889328063 0.514285714 kegg kegg NA NA no no no no no no Breast cancer Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.529565217 0 0 kegg kegg NA NA no no no no no no Breast cancer Glycosphingolipid biosynthesis - globo and isoglobo series -0.426086957 0 0 kegg kegg NA NA no no no no no no Breast cancer Glycosphingolipid biosynthesis - lacto and neolacto series 0.482608696 0 0 kegg kegg NA NA no no no no no no Breast cancer Glyoxylate and dicarboxylate metabolism 0 0.531620553 0 kegg kegg NA NA no no no no no no Breast cancer GnRH secretion 0.850434783 0.807312253 0.818275418 kegg kegg NA NA no no no no up up Breast cancer "Growth hormone synthesis, secretion and action" 0.749565217 0.701581028 0.428571429 kegg kegg NA NA no no no no no no Breast cancer Hedgehog signaling pathway 0.502608696 0 0.642728443 kegg kegg NA NA no no no no no no Breast cancer Hematopoietic cell lineage 0 -0.463438735 0 kegg kegg NA NA no no no no no no Breast cancer Hepatitis B 0.74173913 0.836956522 0.747747748 kegg kegg NA NA no no no no no no Breast cancer Hepatitis C 0.533043478 0 0.584813385 kegg kegg NA NA no no no no no no Breast cancer Herpes simplex virus 1 infection 0 0 -0.403603604 kegg kegg NA NA no no no no no no Breast cancer HIF-1 signaling pathway 0 -0.627470356 0 kegg kegg NA NA no no no no no no Breast cancer Hippo signaling pathway -0.455652174 -0.711462451 0 kegg kegg NA NA no no no no no no Breast cancer Hippo signaling pathway - multiple species 0 0.523715415 0.458944659 kegg kegg NA NA no no no no no no Breast cancer Huntington disease 0 -0.647233202 0 kegg kegg NA NA no no no no no no Breast cancer Inflammatory mediator regulation of TRP channels 0 -0.503952569 0 kegg kegg NA NA no no no no no no Breast cancer Inositol phosphate metabolism 0 0.686758893 0.517631918 kegg kegg NA NA no no no no no no Breast cancer Insulin resistance 0.777391304 0.807312253 0.658944659 kegg kegg NA NA no no no no no no Breast cancer Insulin signaling pathway 0 -0.643280632 0 kegg kegg NA NA no no no no no no Breast cancer JAK-STAT signaling pathway 0.44 0.85770751 0 kegg kegg NA NA no no no no no no Breast cancer Kaposi sarcoma-associated herpesvirus infection 0 0 -0.413127413 kegg kegg NA NA no no no no no dn Breast cancer Lachnospira 0 -0.432913282 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Breast cancer Leishmaniasis -0.431304348 -0.432806324 0 kegg kegg NA NA no no no no no no Breast cancer Leukocyte transendothelial migration 0 -0.503952569 0 kegg kegg NA NA no no no no no no Breast cancer Linoleic acid metabolism -0.590434783 0 0 kegg kegg NA NA no no no no no no Breast cancer Long-term potentiation 0 -0.54743083 0 kegg kegg NA NA no no no no no up Breast cancer Longevity regulating pathway 0.43826087 0.46541502 0 kegg kegg NA NA no no no no no no Breast cancer Lysine degradation 0 0 0.57039897 kegg kegg NA NA no no no no no no Breast cancer Malaria 0 0 -0.478764479 kegg kegg NA NA no no no no no no Breast cancer Mannose type O-glycan biosynthesis 0.48 0 0.516344916 kegg kegg NA NA no no no no no no Breast cancer MAPK signaling pathway 0.42 0.551383399 0.772972973 kegg kegg NA NA no no no no no no Breast cancer Measles 0.453043478 0 0 kegg kegg NA NA no no no no no no Breast cancer Melanogenesis 0 -0.548418972 0 kegg kegg NA NA no no no no no no Breast cancer Melanoma 0.85826087 0.786561265 0.856628057 kegg kegg NA NA no no no no no no Breast cancer Metabolism of xenobiotics by cytochrome P450 -0.709565217 -0.768774704 -0.454054054 kegg kegg NA NA no no no no no no Breast cancer MicroRNAs in cancer 0.503478261 0.792490119 0.866924067 kegg kegg NA NA no no no no no no Breast cancer Mineral absorption 0 0 -0.518404118 kegg kegg NA NA no no no no no no Breast cancer Mismatch repair -0.440869565 -0.530632411 0 kegg kegg NA NA no no no no no no Breast cancer Mitophagy - animal 0 -0.443675889 -0.422908623 kegg kegg NA NA no no no no no no Breast cancer mRNA surveillance pathway 0.486956522 0 0.473101673 kegg kegg NA NA no no no no no no Breast cancer mTOR signaling pathway 0 -0.52173913 0 kegg kegg NA NA no no no no no no Breast cancer N-Glycan biosynthesis 0 -0.490118577 0 kegg kegg NA NA no no no no no no Breast cancer Necroptosis 0 0 -0.487001287 kegg kegg NA NA no no no no no no Breast cancer Neurotrophin signaling pathway 0.606086957 0.5256917 0.534362934 kegg kegg NA NA no no no no no no Breast cancer NF-kappa B signaling pathway 0.511304348 0.792490119 0.544401544 kegg kegg NA NA no no no no no no Breast cancer Nicotinate and nicotinamide metabolism 0 0.612648221 0 kegg kegg NA NA no no no no no no Breast cancer Nicotine addiction 0 0.441699605 0 kegg kegg NA NA no no no no up up Breast cancer Nitrogen metabolism 0 0.504940711 0 kegg kegg NA NA no no no no no no Breast cancer NOD-like receptor signaling pathway 0 0.648221344 0 kegg kegg NA NA no no no no no no Breast cancer Non-alcoholic fatty liver disease 0 -0.541501976 0 kegg kegg NA NA no no no no no no Breast cancer Non-homologous end-joining -0.591304348 -0.575098814 -0.413899614 kegg kegg NA NA no no no no no no Breast cancer Non-small cell lung cancer 0.850434783 0.793478261 0.813127413 kegg kegg NA NA no no no no no no Breast cancer Notch signaling pathway 0.6 0.70256917 0.587387387 kegg kegg NA NA no no no no no no Breast cancer Nucleotide excision repair 0 -0.433794466 0 kegg kegg NA NA no no no no no no Breast cancer Oocyte meiosis 0 -0.716403162 0 kegg kegg NA NA no no no no no no Breast cancer Oscillospira 0 0.41798419 0 LPS-producing kegg Genus NA 0.62 no no no no no no Breast cancer Osteoclast differentiation 0 0.564229249 0 kegg kegg NA NA no no no no no no Breast cancer Other glycan degradation 0 0.541501976 0.464092664 kegg kegg NA NA no no no no no no Breast cancer Other types of O-glycan biosynthesis 0 0 0.523552124 kegg kegg NA NA no no no no no no Breast cancer Oxidative phosphorylation 0 -0.662055336 0 kegg kegg NA NA no no no no no no Breast cancer Oxytocin signaling pathway 0 -0.531620553 -0.438095238 kegg kegg NA NA no no no no no no Breast cancer p53 signaling pathway 0.517391304 0.557312253 0 kegg kegg NA NA no no no no no no Breast cancer Pancreatic cancer 0.502608696 0 0.425740026 kegg kegg NA NA no no no no no no Breast cancer Pancreatic secretion 0 -0.510869565 0 kegg kegg NA NA no no no no no no Breast cancer Pantothenate and CoA biosynthesis 0 0.479249012 0 kegg kegg NA NA no no no no no dn Breast cancer Paraprevotella -0.461170482 0 0 kegg Genus NA 0.118 no no no no no no Breast cancer Parkinson disease 0 -0.638339921 -0.521235521 kegg kegg NA NA no no no no no no Breast cancer Pathways in cancer 0.665217391 0.725296443 0.443758044 kegg kegg NA NA no no no no no no Breast cancer Pathways of neurodegeneration - multiple diseases 0 -0.617588933 -0.506048906 kegg kegg NA NA no no no no no no Breast cancer Pentose and glucuronate interconversions -0.713913043 -0.621541502 0 kegg kegg NA NA no no no no no no Breast cancer Peroxisome 0 0.444664032 0 kegg kegg NA NA no no no no no no Breast cancer Phenylalanine metabolism -0.664347826 -0.62944664 0 kegg kegg NA NA no no no no no no Breast cancer Phosphatidylinositol signaling system 0.505217391 0 0.580952381 kegg kegg NA NA no no no no no no Breast cancer Phospholipase D signaling pathway 0.432173913 0.713438735 0 kegg kegg NA NA no no no no up up Breast cancer Phototransduction 0 -0.851778656 0 kegg kegg NA NA no no no no no no Breast cancer Platelet activation -0.416521739 -0.679841897 0 kegg kegg NA NA no no no no no no Breast cancer Platinum drug resistance 0 0.548418972 0 kegg kegg NA NA no no no no no no Breast cancer PPAR signaling pathway 0 0.527667984 0 kegg kegg NA NA no no no no no no Breast cancer Prevotella 0 0.550154956 0 acetate-producing kegg Genus NA 0.287 no no no no no no Breast cancer Primary bile acid biosynthesis -0.539130435 -0.590909091 0 kegg kegg NA NA no no no no no no Breast cancer Prion disease 0 -0.73715415 0 kegg kegg NA NA no no no no no no Breast cancer Progesterone-mediated oocyte maturation 0.524347826 0.48715415 0.599227799 kegg kegg NA NA no no no no no no Breast cancer Prolactin signaling pathway 0.815652174 0.789525692 0.675675676 kegg kegg NA NA no no no no no no Breast cancer Propanoate metabolism 0 -0.652173913 0 kegg kegg NA NA no no no no no no Breast cancer Prostate cancer 0.737391304 0.653162055 0.574002574 kegg kegg NA NA no no no no no no Breast cancer Proteasome 0 -0.750988142 0 kegg kegg NA NA no no no no no no Breast cancer Protein digestion and absorption 0 0.593873518 0.46975547 yes kegg kegg NA NA no no no no up up Breast cancer Protein export 0 -0.72826087 0 kegg kegg NA NA no no no no no no Breast cancer Protein processing in endoplasmic reticulum 0 -0.471343874 0 kegg kegg NA NA no no no no no no Breast cancer Proteoglycans in cancer 0 -0.64229249 0 kegg kegg NA NA no no no no no no Breast cancer Proximal tubule bicarbonate reclamation 0 -0.656126482 0 kegg kegg NA NA no no no no no no Breast cancer Pyrimidine metabolism -0.493043478 -0.435770751 0 kegg kegg NA NA no no no no no no Breast cancer Pyruvate metabolism -0.407826087 -0.657114625 -0.48030888 kegg kegg NA NA no no no no no no Breast cancer Rap1 signaling pathway 0 -0.492094862 0 kegg kegg NA NA no no no no no no Breast cancer Ras signaling pathway 0 -0.549407115 0 yes kegg kegg NA NA no no no no up up Breast cancer Regulation of actin cytoskeleton -0.648695652 -0.763833992 -0.552123552 kegg kegg NA NA no no no no no no Breast cancer Relaxin signaling pathway 0.583478261 0.528656126 0 kegg kegg NA NA no no no no no no Breast cancer Renal cell carcinoma 0.436521739 0 0 kegg kegg NA NA no no no no no no Breast cancer Renin secretion 0 -0.67687747 -0.403861004 kegg kegg NA NA no no no no no no Breast cancer Retinol metabolism -0.52173913 0 0 kegg kegg NA NA no no no no no no Breast cancer Retrograde endocannabinoid signaling 0 -0.751976285 0 kegg kegg NA NA no no no no no up Breast cancer Ribosome 0 -0.662055336 -0.417245817 kegg kegg NA NA no no no no no no Breast cancer RIG-I-like receptor signaling pathway 0.589565217 0.739130435 0.466666667 kegg kegg NA NA no no no no no no Breast cancer RNA degradation 0.440869565 -0.425889328 0.43011583 kegg kegg NA NA no no no no no no Breast cancer RNA transport 0 -0.481225296 0 kegg kegg NA NA no no no no no no Breast cancer Ruminococcus 0 -0.429421822 0 kegg Genus NA 0.0679 no no no no no dn Breast cancer Shigellosis 0 -0.535573123 -0.552123552 kegg kegg NA NA no no no no no no Breast cancer Signaling pathways regulating pluripotency of stem cells 0.753913043 0.592885375 0.774259974 kegg kegg NA NA no no no no no no Breast cancer Small cell lung cancer 0.600869565 0.743083004 0.47979408 kegg kegg NA NA no no no no no up Breast cancer SNARE interactions in vesicular transport 0 0.618577075 0 kegg kegg NA NA no no no no no no Breast cancer Sphingolipid signaling pathway 0.636521739 0 0.522779923 kegg kegg NA NA no no no no no no Breast cancer Spinocerebellar ataxia 0.587826087 0 0 kegg kegg NA NA no no no no no no Breast cancer Spliceosome 0 0.415019763 0 kegg kegg NA NA no no no no no no Breast cancer Staphylococcus aureus infection -0.42 0 0 kegg kegg NA NA no no no up no no Breast cancer Starch and sucrose metabolism 0 0.587944664 0 kegg kegg NA NA no no no no no no Breast cancer Steroid biosynthesis 0 -0.494071146 0 kegg kegg NA NA no no no no no no Breast cancer Steroid hormone biosynthesis -0.692173913 0 0 kegg kegg NA NA no no no no no no Breast cancer Sulfur metabolism -0.597391304 -0.429841897 0 kegg kegg NA NA no no no no no no Breast cancer T cell receptor signaling pathway 0.447826087 0.564229249 0.438095238 kegg kegg NA NA no no no no no no Breast cancer Taste transduction 0 0 0.486229086 kegg kegg NA NA no no no no no up Breast cancer Taurine and hypotaurine metabolism 0.506086957 0.755928854 0.529214929 kegg kegg NA NA no no no no no no Breast cancer TGF-beta signaling pathway 0 -0.682806324 0 kegg kegg NA NA no no no no no no Breast cancer Thermogenesis 0 -0.686758893 0 kegg kegg NA NA no no no no no no Breast cancer Thiamine metabolism 0 -0.537549407 0 kegg kegg NA NA no no no no no no Breast cancer Thyroid hormone signaling pathway 0 -0.527667984 0 kegg kegg NA NA no no no no no no Breast cancer Tight junction -0.519130435 -0.815217391 -0.618790219 kegg kegg NA NA no no no no no no Breast cancer TNF signaling pathway 0.729565217 0.746047431 0.460746461 kegg kegg NA NA no no no no no no Breast cancer Toll-like receptor signaling pathway 0.627826087 0.626482213 0 yes kegg kegg NA NA no no no no no no Breast cancer Transcriptional misregulation in cancer 0.539130435 0.821146245 0.545945946 kegg kegg NA NA no no no no no no Breast cancer Tryptophan metabolism -0.613043478 -0.588932806 0 kegg kegg NA NA no no no no up no Breast cancer Type II diabetes mellitus 0.857391304 0.868577075 0.71042471 kegg kegg NA NA no no no no no no Breast cancer Tyrosine metabolism -0.664347826 -0.557312253 -0.498841699 kegg kegg NA NA no no no no no no Breast cancer Ubiquinone and other terpenoid-quinone biosynthesis -0.537391304 -0.446640316 0 kegg kegg NA NA no no no no no no Breast cancer Ubiquitin mediated proteolysis 0 -0.479249012 -0.452252252 kegg kegg NA NA no no no no no no Breast cancer "Valine, leucine and isoleucine degradation" -0.537391304 -0.5256917 0 kegg kegg NA NA no no no no no no Breast cancer Vascular smooth muscle contraction 0 -0.754940711 -0.43989704 kegg kegg NA NA no no no no no no Breast cancer Vasopressin-regulated water reabsorption 0 -0.526679842 0 kegg kegg NA NA no no no no no no Breast cancer VEGF signaling pathway 0.78 0.59486166 0.694723295 kegg kegg NA NA no no no no no no Breast cancer Vibrio cholerae infection 0 -0.678853755 0 kegg kegg NA NA no no no no no no Breast cancer Viral protein interaction with cytokine and cytokine receptor 0 0 -0.625225225 kegg kegg NA NA no no no no no no Breast cancer Vitamin digestion and absorption 0.533913043 0 0.43963964 kegg kegg NA NA no no no no no no Breast cancer Wnt signaling pathway 0 0 0.513513514 kegg kegg NA NA no no no no no no Butanoate metabolism "Alanine, aspartate and glutamate metabolism" 0 -0.668972332 0 kegg kegg NA NA no no no no no no Butanoate metabolism alpha-Linolenic acid metabolism 0.629565217 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Amino sugar and nucleotide sugar metabolism 0.651304348 0 0.425225225 kegg kegg NA NA no no no no no no Butanoate metabolism Arginine and proline metabolism 0 -0.631422925 0 kegg kegg NA NA no no no no up no Butanoate metabolism Arginine biosynthesis 0 -0.674901186 0 kegg kegg NA NA no no no no no no Butanoate metabolism Ascorbate and aldarate metabolism 0.42 0.504940711 0.507078507 kegg kegg NA NA no no no no no no Butanoate metabolism beta-Alanine metabolism 0.86 0.717391304 0.773230373 kegg kegg NA NA no no no no no no Butanoate metabolism Citrate cycle (TCA cycle) 0.826086957 0.949604743 0.702702703 kegg kegg NA NA no no no no no no Butanoate metabolism Cysteine and methionine metabolism 0.535652174 0.902173913 0.6996139 kegg kegg NA NA no no no no no no Butanoate metabolism Ether lipid metabolism 0 0.416007905 0.427541828 kegg kegg NA NA no no no no no no Butanoate metabolism Fatty acid biosynthesis 0 -0.618577075 0 kegg kegg NA NA no no no no no no Butanoate metabolism Fatty acid degradation 0.434782609 0 0.480566281 kegg kegg NA NA no no no no no no Butanoate metabolism Fatty acid elongation 0.696521739 0.699604743 0.80978121 kegg kegg NA NA no no no no no no Butanoate metabolism Fructose and mannose metabolism 0.7 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Galactose metabolism 0.645217391 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Glutathione metabolism 0 0.416996047 0 kegg kegg NA NA no no no no no no Butanoate metabolism "Glycine, serine and threonine metabolism" 0.446956522 0 0 kegg kegg NA NA no no no no up no Butanoate metabolism Glycolysis / Gluconeogenesis 0.813913043 0.759881423 0.646332046 kegg kegg NA NA no no no no no no Butanoate metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.733201581 0 kegg kegg NA NA no no no no no no Butanoate metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.685217391 0.577075099 0 kegg kegg NA NA no no no no no no Butanoate metabolism Glycosphingolipid biosynthesis - ganglio series 0 0.601778656 0 kegg kegg NA NA no no no no no no Butanoate metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.454782609 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Glyoxylate and dicarboxylate metabolism 0 -0.673913043 0 kegg kegg NA NA no no no no no no Butanoate metabolism Histidine metabolism 0.527826087 0 0.409009009 kegg kegg NA NA no no no no no no Butanoate metabolism N-Glycan biosynthesis 0 0.768774704 0 kegg kegg NA NA no no no no no no Butanoate metabolism Oxidative phosphorylation -0.556521739 0 0 kegg kegg NA NA no no no no no no Butanoate metabolism Pentose and glucuronate interconversions 0.599130435 0.914031621 0.56988417 kegg kegg NA NA no no no no no no Butanoate metabolism Pentose phosphate pathway 0 -0.432806324 0 kegg kegg NA NA no no no no no no Butanoate metabolism Phenylalanine metabolism 0.740869565 0.861660079 0 kegg kegg NA NA no no no no no no Butanoate metabolism Primary bile acid biosynthesis 0.736521739 0.693675889 0.522007722 kegg kegg NA NA no no no no no no Butanoate metabolism Propanoate metabolism 0.639130435 0.861660079 0.754440154 kegg kegg NA NA no no no no no no Butanoate metabolism Pyrimidine metabolism 0.71826087 0.68972332 0 kegg kegg NA NA no no no no no no Butanoate metabolism Pyruvate metabolism 0.705217391 0.873517787 0.783011583 kegg kegg NA NA no no no no no no Butanoate metabolism Selenocompound metabolism 0 0 0.406435006 kegg kegg NA NA no no no no no no Butanoate metabolism Starch and sucrose metabolism 0 -0.494071146 0 kegg kegg NA NA no no no no no no Butanoate metabolism Steroid biosynthesis 0 0.696640316 0.596396396 kegg kegg NA NA no no no no no no Butanoate metabolism Steroid hormone biosynthesis 0.499130435 0.761857708 0 kegg kegg NA NA no no no no no no Butanoate metabolism Synthesis and degradation of ketone bodies 0.651304348 0.770750988 0.715830116 kegg kegg NA NA no no no no no no Butanoate metabolism Taurine and hypotaurine metabolism 0 -0.445652174 0 kegg kegg NA NA no no no no no no Butanoate metabolism Tryptophan metabolism 0.915652174 0.851778656 0.814157014 kegg kegg NA NA no no no no up no Butanoate metabolism Tyrosine metabolism 0.707826087 0.866600791 0.713770914 kegg kegg NA NA no no no no no no Butanoate metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.780869565 0.851778656 0.60952381 kegg kegg NA NA no no no no no no Butanoate metabolism "Valine, leucine and isoleucine degradation" 0.895652174 0.941699605 0.906048906 kegg kegg NA NA no no no no no no Butanoate metabolism Various types of N-glycan biosynthesis 0 0.698616601 0 kegg kegg NA NA no no no no no no butyric acid C4+blood 15-HETE+blood 0.456073694 0 0 serum_scfa serum_ARA 0.407 0.819 no no no no no no butyric acid C4+blood 16:0/14:0-PC+blood 0 -0.517156863 0 serum_scfa serum_phospholipids 0.407 0.0206 no no no no up up butyric acid C4+blood 16:0/18:0-PC+blood 0 -0.495098039 0 serum_scfa serum_phospholipids 0.407 0.521 no no no no no no butyric acid C4+blood 16:0/20:3-PC+blood 0 -0.558823529 0 serum_scfa serum_phospholipids 0.407 5.43E-06 no no no no up up butyric acid C4+blood 16:1/16:1-PC+blood 0 -0.573529412 0 serum_scfa serum_phospholipids 0.407 0.0177 no no no no no up butyric acid C4+blood 18:0/18:0-PC+blood 0 -0.571078431 0 serum_scfa serum_phospholipids 0.407 0.426 no no no no no no butyric acid C4+blood 18:0/18:1-PC+blood 0 -0.526960784 0 serum_scfa serum_phospholipids 0.407 0.393 no no no no no no butyric acid C4+blood 18:0/18:1-PI+blood -0.572932331 0 0 serum_scfa serum_phospholipids 0.407 0.599 no no no no no no butyric acid C4+blood 18:0/20:3-PC+blood 0 -0.49754902 0 serum_scfa serum_phospholipids 0.407 0.0682 no no no no up no butyric acid C4+blood 18:0/20:5-PC+blood 0.584962406 0 0 serum_scfa serum_phospholipids 0.407 0.17 no no no no no no butyric acid C4+blood 18:0/22:6-PA+blood 0 -0.617647059 0 serum_scfa serum_phospholipids 0.407 0.22 no no no no no no butyric acid C4+blood 18:1/16:0-PI+blood -0.542857143 0 0 serum_scfa serum_phospholipids 0.407 0.793 no no no no no no butyric acid C4+blood 18:1/18:2-PI+blood -0.493233083 0 0 serum_scfa serum_phospholipids 0.407 0.0164 no no no dn no up butyric acid C4+blood 18:2-LPC+blood 0 0.541666667 0 serum_scfa serum_phospholipids 0.407 0.00743 no no no dn no up butyric acid C4+blood 18:3-LPC+blood 0 0.492647059 0 serum_scfa serum_phospholipids 0.407 0.147 no no no no no no butyric acid C4+blood 18:3n3+blood 0.44962406 0 0 serum_scfa serum_fattyacid 0.407 0.291 no no no no no no butyric acid C4+blood 2-methyl-butyric acid m-C4+blood 0.490225564 0 0.573333333 serum_scfa serum_scfa 0.407 0.262 no no no no no no butyric acid C4+blood 20:2/18:0-PC+blood 0 -0.487745098 0 serum_scfa serum_phospholipids 0.407 0.0427 no no no no up no butyric acid C4+blood 20:3/18:0-PC+blood 0 -0.514705882 0 serum_scfa serum_phospholipids 0.407 0.296 no no no no no no butyric acid C4+blood 20:3/18:0-PI+blood 0 -0.5 0 serum_scfa serum_phospholipids 0.407 0.289 no no no no no no butyric acid C4+blood 22:0/16:0-PE+blood 0 0 -0.475555556 serum_scfa serum_phospholipids 0.407 0.091 no no no no no up butyric acid C4+blood 5-HETE+blood 0 0 -0.442198142 serum_scfa serum_ARA 0.407 0.697 no no no no no no butyric acid C4+blood 9-HODE+blood 0 0.637254902 0 serum_scfa serum_ARA 0.407 0.297 no no no no no no Butyric acid+stool Acetic acid+stool 0.661506708 0.664335664 0.839920949 yes yes stool_scfa stool_scfa 0.102 0.0656 dn no no dn no no Butyric acid+stool Alcoholism 0 0 -0.451157538 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Blautia -0.506707946 0 0 yes acetate-producing stool_scfa Genus 0.102 1.36E-05 dn no no up dn dn Butyric acid+stool Butyricicoccus 0 0 0.543750985 yes butyrate-producing stool_scfa Genus 0.102 0.852 dn no no no no no Butyric acid+stool Butyricimonas 0 -0.652602405 0 yes butyrate-producing stool_scfa Genus 0.102 0.17 dn no no no no no Butyric acid+stool Cell cycle 0.585139319 0 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Chemokine signaling pathway -0.481940144 0 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Clostridium -0.628814167 0 -0.469986125 yes stool_scfa Genus 0.102 0.925 dn no no no no no Butyric acid+stool Clostridium -0.628814167 0 0.429948123 yes stool_scfa Genus 0.102 0.925 dn no no no no no Butyric acid+stool Coprococcus 0 0 0.536561265 yes butyrate-producing stool_scfa Genus 0.102 0.612 dn no no no no no Butyric acid+stool Epithelial cell signaling in Helicobacter pylori infection -0.484004128 0 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Faecalibacterium 0.504643963 0 0 yes butyrate-producing stool_scfa Genus 0.102 0.0039 dn no no no dn dn Butyric acid+stool Glioma 0 -0.763636364 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Glucagon signaling pathway 0.59752322 0 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Long-term potentiation 0.473684211 0 0 yes stool_scfa kegg 0.102 NA dn no no no no up Butyric acid+stool Lysosome -0.475748194 0 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Mineral absorption 0 0.654545455 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Mitophagy - animal 0 0.754545455 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Neutrophil extracellular trap formation -0.533539732 0 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Osteoclast differentiation -0.50877193 0 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Pancreatic cancer 0 -0.645454545 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Pathogenic Escherichia coli infection -0.469556244 0 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Pathways in cancer 0 0 -0.444381705 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Phosphatidylinositol signaling system 0 -0.618181818 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Protein processing in endoplasmic reticulum 0.547987616 0 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Purine metabolism 0.519091847 0 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Shigellosis 0 0.772727273 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Thyroid hormone synthesis 0.50877193 0 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool Ubiquitin mediated proteolysis 0 0.754545455 0 yes stool_scfa kegg 0.102 NA dn no no no no no Butyric acid+stool ¦Ø-MCA+stool -0.498497246 0 0 yes stool_scfa stool_bileacids 0.102 0.919 dn no no no no no Butyricicoccus Wautersiella 0.443634386 0 0 butyrate-producing Genus Genus 0.852 0.289 no no no no no no C-peptide 15-HETE+blood 0 0 -0.674346986 DM-assocaited hormones serum_ARA 0.228 0.819 no no no no no no C-peptide 16:0/20:3-PC+blood 0 0 0.44 DM-assocaited hormones serum_phospholipids 0.228 5.43E-06 no no no no up up C-peptide 16:0/20:5-PC+blood 0 -0.485294118 0 DM-assocaited hormones serum_phospholipids 0.228 0.628 no no no no no no C-peptide 16:0/22:6-PC+blood 0 -0.495098039 0 DM-assocaited hormones serum_phospholipids 0.228 4.53E-05 no no no no up up C-peptide 18:0-LPA+blood 0 0 0.493043478 DM-assocaited hormones serum_phospholipids 0.228 0.0725 no no no no dn no C-peptide 18:1/18:1-PC+blood 0 0 0.448695652 DM-assocaited hormones serum_phospholipids 0.228 1.34E-05 no no no no up up C-peptide 18:2-LPA+blood 0 0 0.41826087 DM-assocaited hormones serum_phospholipids 0.228 0.00684 no no no dn no up C-peptide 20:1-LPA+blood 0 0 0.416521739 DM-assocaited hormones serum_phospholipids 0.228 0.0187 no no no dn dn no C-peptide 20:3n6+blood 0 0.544117647 0 DM-assocaited hormones serum_fattyacid 0.228 0.0884 no no no up no no C-peptide ACA+stool 0.50424075 0 0 DM-assocaited hormones stool_bileacids 0.228 0.417 no no no no no no C-peptide Aldosterone synthesis and secretion 0.587803501 0 0 DM-assocaited hormones kegg 0.228 NA no no no no up up C-peptide Amphetamine addiction 0.577639752 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Anaerostipes -0.427626531 0 0 butyrate-producing DM-assocaited hormones Genus 0.228 0.568 no no no no no no C-peptide Antigen processing and presentation -0.639751553 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Arginine and proline metabolism -0.611518916 0 0 DM-assocaited hormones kegg 0.228 NA no no no no up no C-peptide Bifidobacterium 0 0.42004457 0 acetate-producing DM-assocaited hormones Genus 0.228 0.105 no no no no dn no C-peptide CDCA+stool 0 0.587412587 0 DM-assocaited hormones stool_bileacids 0.228 0.663 no no no no no no C-peptide Chemical carcinogenesis - receptor activation 0.588932806 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Choline+blood 0 0 0.45826087 DM-assocaited hormones serum_choline 0.228 0.0395 no no no no up no C-peptide Collinsella 0 0.404793989 0 DM-assocaited hormones Genus 0.228 0.128 no no no no no no C-peptide Cushing syndrome 0.658949746 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no up C-peptide DCA+blood -0.471620227 0 0 DM-assocaited hormones serum_bileacids 0.228 0.122 no no no no no no C-peptide DMG+blood 0 0 0.455652174 DM-assocaited hormones serum_choline 0.228 0.909 no no no no no no C-peptide Endocrine resistance 0.648785997 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Epstein-Barr virus infection -0.570863919 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Fc gamma R-mediated phagocytosis -0.452286844 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide GABAergic synapse -0.46809712 0 0 DM-assocaited hormones kegg 0.228 NA no no no no up up C-peptide Gap junction 0.450028233 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide GCDCA+stool 0.508823529 0.727272727 0 yes DM-assocaited hormones stool_bileacids 0.228 0.0471 no no no no dn no C-peptide GnRH signaling pathway 0.431959345 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide "Growth hormone synthesis, secretion and action" 0.435347261 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide HDCA+stool 0 0 -0.487012987 DM-assocaited hormones stool_bileacids 0.228 0.176 no no no no no no C-peptide Herpes simplex virus 1 infection -0.599096556 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Human cytomegalovirus infection -0.560700169 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no dn C-peptide Human immunodeficiency virus 1 infection -0.581027668 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Human papillomavirus infection 0 0.459486166 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Human T-cell leukemia virus 1 infection -0.605872388 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide IL-8 0 0 -0.540229885 DM-assocaited hormones serum_cytokines 0.228 0.579 no no no no no no C-peptide Inflammatory mediator regulation of TRP channels 0.4432524 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide IP-10 0 0.490909091 0 DM-assocaited hormones serum_cytokines 0.228 0.394 no no no no no no C-peptide L-Isoleucine+blood 0 0 0.486086957 yes DM-assocaited hormones serum_aminoacids 0.228 5.47E-06 no no no up up no C-peptide L-Leucine+blood 0 0 0.486956522 yes DM-assocaited hormones serum_aminoacids 0.228 3.22E-05 no no no up up no C-peptide L-Phenylalanine+blood 0 0.593137255 0 yes DM-assocaited hormones serum_aminoacids 0.228 0.0103 no no no up up no C-peptide L-Proline+blood 0 0.681372549 0 yes DM-assocaited hormones serum_aminoacids 0.228 0.00265 no no no up up no C-peptide L-Tryptophan+blood 0 0.693627451 0 DM-assocaited hormones serum_aminoacids 0.228 0.164 no no no no no no C-peptide L-Tyrosine+blood 0 0.669117647 0.446086957 yes DM-assocaited hormones serum_aminoacids 0.228 0.00913 no no no up up no C-peptide LCA+stool 0 0 -0.475324675 DM-assocaited hormones stool_bileacids 0.228 0.314 no no no no no no C-peptide Long-term depression 0.444381705 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Long-term potentiation 0 -0.470355731 0 DM-assocaited hormones kegg 0.228 NA no no no no no up C-peptide Melanogenesis 0.541501976 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Morphine addiction 0.427442123 0 0 DM-assocaited hormones kegg 0.228 NA no no no no up up C-peptide n6/n3+blood 0 0.485294118 0 DM-assocaited hormones serum_fattyacid 0.228 0.226 no no no no no no C-peptide Neutrophil extracellular trap formation -0.489553924 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide NOD-like receptor signaling pathway -0.526821005 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Odoribacter -0.481440095 0 0 butyrate-producing DM-assocaited hormones Genus 0.228 0.798 no no no no no no C-peptide Olfactory transduction -0.445511011 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Oscillospira 0.461462451 0 0 LPS-producing DM-assocaited hormones Genus 0.228 0.62 no no no no no no C-peptide Osteoclast differentiation -0.438735178 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Pancreatic secretion 0.457933371 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Parabacteroides 0 -0.565217391 0 DM-assocaited hormones Genus 0.228 4.19E-05 no no no no up up C-peptide "Parathyroid hormone synthesis, secretion and action" 0 0 -0.416109626 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Peroxisome -0.61038961 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Phenylacetic acid+stool 0 -0.622377622 0 DM-assocaited hormones stool_cometabolism 0.228 0.785 no no no no no no C-peptide Prolactin signaling pathway 0 0.510869565 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Proteasome -0.429700734 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide Roseburia 0 0.54011743 0 butyrate-producing DM-assocaited hormones Genus 0.228 0.495 no no no no no no C-peptide Ruminococcus 0.617588933 0 0 acetate-producing DM-assocaited hormones Genus 0.228 0.335 no no no no no no C-peptide Systemic lupus erythematosus -0.476002259 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-peptide total_stool_scfa+stool 0 -0.713286713 0 DM-assocaited hormones stool_scfa 0.228 0.0534 no no no dn no up C-peptide Valine+blood 0 0 0.563478261 yes DM-assocaited hormones serum_aminoacids 0.228 1.22E-06 no no no up up no C-peptide Wnt signaling pathway 0.426312818 0 0 DM-assocaited hormones kegg 0.228 NA no no no no no no C-type lectin receptor signaling pathway 2-Oxocarboxylic acid metabolism -0.690434783 -0.572134387 -0.408751609 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Adherens junction -0.413913043 -0.566205534 -0.455598456 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Adrenergic signaling in cardiomyocytes 0 -0.565217391 0 kegg kegg NA NA no no no no no up C-type lectin receptor signaling pathway "Alanine, aspartate and glutamate metabolism" 0.485217391 0.696640316 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Amino sugar and nucleotide sugar metabolism -0.451304348 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Aminoacyl-tRNA biosynthesis -0.420869565 -0.489130435 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Antifolate resistance -0.459130435 -0.503952569 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Apelin signaling pathway 0 -0.652173913 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Apoptosis 0 0.858695652 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Arachidonic acid metabolism -0.545217391 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Arginine and proline metabolism 0 0.751976285 0.591248391 kegg kegg NA NA no no no no up no C-type lectin receptor signaling pathway Arginine biosynthesis 0.440869565 0.688735178 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Ascorbate and aldarate metabolism 0 -0.438735178 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Autophagy - animal 0.791304348 0.820158103 0.451480051 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Autophagy - other 0.577391304 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Axon guidance 0.54173913 0 0 kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway Basal transcription factors 0 -0.530632411 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Base excision repair 0 -0.508893281 -0.484942085 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway beta-Alanine metabolism -0.623478261 0 -0.596396396 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Biosynthesis of amino acids 0 0.572134387 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Biosynthesis of cofactors -0.725217391 -0.684782609 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Biosynthesis of unsaturated fatty acids -0.547826087 -0.43083004 -0.612870013 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Butanoate metabolism -0.666956522 -0.72826087 -0.656628057 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway cAMP signaling pathway 0.552173913 0.618577075 0.55006435 yes kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway Carbon metabolism -0.520869565 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Cardiac muscle contraction 0 -0.587944664 0 kegg kegg NA NA no no no no no up C-type lectin receptor signaling pathway Cell adhesion molecules 0 0.553359684 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Cell cycle 0 -0.679841897 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Cellular senescence 0 0.694664032 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway cGMP-PKG signaling pathway 0.640869565 0.663043478 0.496010296 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Chemokine signaling pathway 0.423478261 0.653162055 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Citrate cycle (TCA cycle) -0.655652174 -0.75 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Complement and coagulation cascades 0 0.54743083 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Cysteine and methionine metabolism -0.406086957 -0.706521739 -0.565250965 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Cytokine-cytokine receptor interaction 0 0 -0.458429858 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Cytosolic DNA-sensing pathway 0 0.690711462 0.438352638 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway DNA replication 0 -0.829051383 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Drug metabolism - cytochrome P450 0 -0.833003953 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Drug metabolism - other enzymes -0.573043478 -0.722332016 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway ECM-receptor interaction -0.516521739 -0.484189723 0 kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.490118577 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Endocytosis 0 0.572134387 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway ErbB signaling pathway 0.592173913 0.514822134 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Ether lipid metabolism 0 -0.548418972 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Fanconi anemia pathway 0 -0.475296443 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Fatty acid biosynthesis 0.453043478 0.694664032 0.439382239 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Fatty acid degradation 0 0.436758893 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Fatty acid elongation -0.53826087 0 -0.582496782 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Focal adhesion -0.517391304 -0.574110672 -0.517117117 kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway FoxO signaling pathway 0 0.453557312 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Galactose metabolism 0 0.466403162 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Gap junction -0.416521739 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Glutathione metabolism -0.496521739 -0.700592885 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway "Glycine, serine and threonine metabolism" -0.613043478 -0.527667984 0 kegg kegg NA NA no no no no up no C-type lectin receptor signaling pathway Glycolysis / Gluconeogenesis -0.615652174 -0.511857708 -0.443243243 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.54 0.73715415 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.654782609 -0.421936759 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 -0.517786561 -0.446332046 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.426086957 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.716403162 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Hedgehog signaling pathway 0 -0.445652174 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway HIF-1 signaling pathway 0 -0.477272727 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Hippo signaling pathway -0.608695652 -0.623517787 -0.553153153 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Hippo signaling pathway - multiple species 0.496521739 0.62944664 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Longevity regulating pathway - multiple species 0 0 -0.46975547 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Lysosome 0.426086957 0.528656126 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.794466403 -0.403861004 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Mismatch repair -0.547826087 -0.785573123 -0.592792793 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway mRNA surveillance pathway 0 -0.481225296 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway mTOR signaling pathway 0 -0.459486166 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway N-Glycan biosynthesis 0 -0.753952569 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Neuroactive ligand-receptor interaction 0 0.451581028 0 kegg kegg NA NA no no no up up up C-type lectin receptor signaling pathway Neutrophil extracellular trap formation 0 0.504940711 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway NF-kappa B signaling pathway 0.536521739 0.863636364 0.847619048 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Nicotinate and nicotinamide metabolism 0.44 0.707509881 0.491891892 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Nitrogen metabolism 0.407826087 0.650197628 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway NOD-like receptor signaling pathway 0.44 0.927865613 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Non-homologous end-joining -0.646086957 -0.53458498 -0.601029601 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Notch signaling pathway 0.536521739 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Nucleotide excision repair 0 -0.81916996 -0.623423423 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway One carbon pool by folate -0.499130435 -0.833003953 -0.434749035 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Oocyte meiosis 0 -0.625494071 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Osteoclast differentiation 0.489565217 0.872529644 0.67001287 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Oxidative phosphorylation 0 -0.611660079 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Pantothenate and CoA biosynthesis 0 0.601778656 0 kegg kegg NA NA no no no no no dn C-type lectin receptor signaling pathway Paraprevotella -0.477190089 0 0 kegg Genus NA 0.118 no no no no no no C-type lectin receptor signaling pathway Pentose and glucuronate interconversions -0.682608696 -0.735177866 -0.405148005 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Pentose phosphate pathway 0 0.539525692 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Peroxisome 0 0.562252964 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Phagosome 0 0.542490119 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Phenylalanine metabolism -0.820869565 -0.7243083 -0.580952381 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Phospholipase D signaling pathway 0 0.615612648 0 kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway Platelet activation -0.53826087 -0.528656126 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Porphyrin and chlorophyll metabolism -0.572173913 -0.462450593 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway PPAR signaling pathway 0.435652174 0.809288538 0.553667954 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Primary bile acid biosynthesis -0.597391304 -0.479249012 -0.449163449 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Propanoate metabolism 0 -0.668972332 -0.52972973 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Proteasome 0 -0.545454545 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Protein export 0 -0.621541502 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Protein processing in endoplasmic reticulum -0.444347826 -0.707509881 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Purine metabolism -0.420869565 -0.492094862 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Pyrimidine metabolism -0.428695652 -0.802371542 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Pyruvate metabolism -0.524347826 -0.763833992 -0.62033462 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Ras signaling pathway 0 -0.696640316 0 yes kegg kegg NA NA no no no no up up C-type lectin receptor signaling pathway Renin-angiotensin system 0 0.638339921 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Retinol metabolism -0.491304348 -0.695652174 -0.466409266 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Ribosome 0 -0.561264822 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Ribosome biogenesis in eukaryotes 0 -0.626482213 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway RIG-I-like receptor signaling pathway 0.873913043 0.884387352 0.87001287 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway RNA degradation 0 -0.60770751 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway RNA polymerase 0 -0.68972332 -0.409009009 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Sarcina 0 0.444554224 0 kegg Genus NA 0.0703 no no no no no no C-type lectin receptor signaling pathway Signaling pathways regulating pluripotency of stem cells 0.52173913 0 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway SNARE interactions in vesicular transport 0 0.522727273 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Sphingolipid signaling pathway 0.675652174 0.688735178 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Starch and sucrose metabolism 0 0.599802372 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Steroid biosynthesis 0 -0.730237154 -0.663577864 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Steroid hormone biosynthesis -0.488695652 -0.68083004 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Sulfur metabolism -0.5 -0.455533597 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Synthesis and degradation of ketone bodies -0.44 -0.752964427 -0.548777349 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Terpenoid backbone biosynthesis 0 -0.432806324 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway TGF-beta signaling pathway 0 -0.561264822 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Thiamine metabolism 0 -0.566205534 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Tight junction -0.482608696 -0.505928854 -0.45971686 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Toll-like receptor signaling pathway 0.763478261 0.958498024 0.741570142 yes kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Tryptophan metabolism -0.675652174 -0.592885375 0 kegg kegg NA NA no no no no up no C-type lectin receptor signaling pathway Tyrosine metabolism -0.827826087 -0.837944664 -0.801801802 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.602608696 -0.744071146 -0.555212355 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Ubiquitin mediated proteolysis 0 -0.496047431 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway "Valine, leucine and isoleucine degradation" -0.626956522 -0.760869565 -0.642213642 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Various types of N-glycan biosynthesis 0 -0.589920949 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Vascular smooth muscle contraction 0 -0.683794466 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway VEGF signaling pathway 0.708695652 0.598814229 0 kegg kegg NA NA no no no no no no C-type lectin receptor signaling pathway Wnt signaling pathway 0 -0.677865613 0 kegg kegg NA NA no no no no no no CA+blood 12-ketoDCA+blood 0.509987079 0 0 serum_bileacids serum_bileacids 0.606 0.517 no no no no no no CA+blood 14:0/20:4-PC+blood 0 0.605763449 0 serum_bileacids serum_phospholipids 0.606 0.486 no no no no no no CA+blood 16:0/16:0-PC+blood 0 -0.491722962 0 serum_bileacids serum_phospholipids 0.606 0.00079 no no no no up up CA+blood 16:0/18:1-PC+blood 0 -0.50398538 0 serum_bileacids serum_phospholipids 0.606 6.15E-07 no no no up up up CA+blood 16:0/18:2-PC+blood 0 -0.488044236 0 serum_bileacids serum_phospholipids 0.606 3.24E-06 no no no no up up CA+blood 16:0/20:5-PC+blood 0 0 0.468956447 serum_bileacids serum_phospholipids 0.606 0.628 no no no no no no CA+blood 16:0/20:5-PG+blood -0.47461455 0 0 serum_bileacids serum_phospholipids 0.606 0.00656 no no no no up no CA+blood 18:0/16:0-PC+blood 0 -0.535867667 0 serum_bileacids serum_phospholipids 0.606 9.64E-07 no no no up up up CA+blood 18:0/20:3-PI+blood -0.610003804 0 0 serum_bileacids serum_phospholipids 0.606 0.377 no no no no no no CA+blood 18:0/20:4-PI+blood -0.544565665 0 0 serum_bileacids serum_phospholipids 0.606 0.167 no no no no no no CA+blood 18:0/22:6-PA+blood -0.464084275 0 0 serum_bileacids serum_phospholipids 0.606 0.22 no no no no no no CA+blood 18:1-LPE+blood 0.473862388 0 0 serum_bileacids serum_phospholipids 0.606 0.117 no no no no no no CA+blood 18:1/16:0-PC+blood 0 -0.492949204 0 serum_bileacids serum_phospholipids 0.606 2.43E-05 no no no no up up CA+blood 18:1/18:0-PS+blood -0.574652165 0 0 serum_bileacids serum_phospholipids 0.606 0.193 no no no no no no CA+blood 18:1/18:1-PG+blood -0.523505114 0 0 serum_bileacids serum_phospholipids 0.606 0.00352 no no no no up up CA+blood 18:1/20:3-PC+blood 0 0 -0.459350902 serum_bileacids serum_phospholipids 0.606 0.00872 no no no no up up CA+blood 18:1/22:6-PE+blood -0.451297512 -0.492949204 0 serum_bileacids serum_phospholipids 0.606 0.0047 no no no no up no CA+blood 18:1+blood -0.466340763 0 -0.417498169 yes serum_bileacids serum_fattyacid 0.606 0.00202 no no no up no dn CA+blood 18:2-LPE+blood 0.484392663 0 0 serum_bileacids serum_phospholipids 0.606 0.112 no no no no no no CA+blood 18:2/18:1-PC+blood 0 0.620478351 0 serum_bileacids serum_phospholipids 0.606 2.30E-05 no no no dn up up CA+blood 18:2/18:2-PC+blood 0 0.658491847 0 serum_bileacids serum_phospholipids 0.606 1.98E-05 no no no dn up up CA+blood 18:2/20:4-PC+blood -0.449041025 0 0 serum_bileacids serum_phospholipids 0.606 0.0145 no no no no no up CA+blood 18:3-LPC+blood 0.47461455 0.49049672 0 serum_bileacids serum_phospholipids 0.606 0.147 no no no no no no CA+blood 18:3/18:2-PC+blood 0 0.581238613 0 serum_bileacids serum_phospholipids 0.606 0.0394 no no no no no up CA+blood 18:3n6+blood 0 0.505211622 0 serum_bileacids serum_fattyacid 0.606 0.0463 no no no up no dn CA+blood 2-methyl-butyric acid m-C4+blood 0 0 -0.440825922 serum_bileacids serum_scfa 0.606 0.262 no no no no no no CA+blood 20:0/20:5-PC+blood -0.72809332 0 0 serum_bileacids serum_phospholipids 0.606 0.882 no no no no no no CA+blood 20:1/20:4-PC+blood 0 -0.483139269 0 serum_bileacids serum_phospholipids 0.606 0.0419 no no no no no up CA+blood 20:1/20:4-PE+blood -0.48063185 0 0 serum_bileacids serum_phospholipids 0.606 0.0042 no no no up up no CA+blood 20:2+blood 0 0 -0.668614569 serum_bileacids serum_fattyacid 0.606 0.478 no no no no no no CA+blood 20:3/18:0-PI+blood -0.494922938 0 0 serum_bileacids serum_phospholipids 0.606 0.289 no no no no no no CA+blood 20:4/16:0-PE+blood 0 0.500306654 0 serum_bileacids serum_phospholipids 0.606 0.00529 no no no no up up CA+blood 20:5/18:0-PC+blood -0.472358063 0 0 serum_bileacids serum_phospholipids 0.606 3.97E-06 no no no no up up CA+blood 20:5n3+blood 0 0 0.516984174 serum_bileacids serum_fattyacid 0.606 0.988 no no no no no no CA+blood 24:0+blood -0.497179426 0 0 serum_bileacids serum_fattyacid 0.606 0.034 no no no dn no up CA+blood acetic acid C2+blood -0.533283227 0 0 serum_bileacids serum_scfa 0.606 0.000193 no no no up dn no CA+blood Acute myeloid leukemia 0 -0.522443114 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Adrenergic signaling in cardiomyocytes 0 0.812362251 0.550583254 serum_bileacids kegg 0.606 NA no no no no no up CA+blood AGE-RAGE signaling pathway in diabetic complications 0 -0.657836823 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Akkermansia -0.538053088 0 0 acetate-producing serum_bileacids Genus 0.606 0.23 no no no no no no CA+blood Aldosterone synthesis and secretion 0 0.722590335 0.612359777 serum_bileacids kegg 0.606 NA no no no no up up CA+blood Allograft rejection 0 -0.644591786 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Alzheimer disease 0 0.746137067 0.400775188 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Amoebiasis 0 -0.531273139 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Amphetamine addiction 0 0.760853775 0.530505885 serum_bileacids kegg 0.606 NA no no no no no no CA+blood AMPK signaling pathway 0.458973278 0.788815519 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Amyotrophic lateral sclerosis 0 0.746137067 0.491123352 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Apelin signaling pathway 0 0.743193726 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Apoptosis 0 -0.559234883 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Arginine and proline metabolism 0 -0.626931737 0 serum_bileacids kegg 0.606 NA no no no no up no CA+blood Autoimmune thyroid disease 0 -0.644591786 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Betaine+blood 0 0 -0.446314805 serum_bileacids serum_choline 0.606 0.857 no no no no no no CA+blood Bifidobacterium -0.490594432 0 0 acetate-producing serum_bileacids Genus 0.606 0.105 no no no no dn no CA+blood Biosynthesis of amino acids 0 -0.61221503 -0.485717906 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Bladder cancer 0 -0.618101713 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Blautia -0.485896988 0 0 acetate-producing serum_bileacids Genus 0.606 1.36E-05 no no no up dn dn CA+blood CA+stool 0 0 0.525772664 serum_bileacids stool_bileacids 0.606 0.827 no no no no no no CA+blood Calcium signaling pathway 0 0.51361309 0.505023069 serum_bileacids kegg 0.606 NA no no no no up up CA+blood Carbon metabolism 0 0 -0.488806732 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Cardiac muscle contraction 0 0.701986945 0.437068895 serum_bileacids kegg 0.606 NA no no no no no up CA+blood Cell adhesion molecules 0 -0.615158371 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Cellular senescence 0 -0.582781615 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Central carbon metabolism in cancer 0 0.520971443 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood cGMP-PKG signaling pathway 0 -0.597498322 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Chemokine signaling pathway 0 -0.575423261 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Cocaine addiction 0 0 0.406180634 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Coprococcus 0 0 -0.555406356 butyrate-producing serum_bileacids Genus 0.606 0.612 no no no no no no CA+blood Coronavirus disease - COVID-19 0 0.763797116 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Cortisol synthesis and secretion 0 0 0.50270645 serum_bileacids kegg 0.606 NA no no no no no up CA+blood Cushing syndrome 0 0.663723506 0.491895558 serum_bileacids kegg 0.606 NA no no no no no up CA+blood Cytokine-cytokine receptor interaction 0 -0.563649895 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Diabetic cardiomyopathy 0 0.734363701 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Dopaminergic synapse 0 0.587196627 0.527417059 serum_bileacids kegg 0.606 NA no no no no up no CA+blood EGFR tyrosine kinase inhibitor resistance 0 0.800588885 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Endocytosis 0 -0.606328347 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Epithelial cell signaling in Helicobacter pylori infection 0 -0.507726407 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Fc epsilon RI signaling pathway 0 -0.67255353 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Fc gamma R-mediated phagocytosis -0.479157571 -0.669610189 -0.50038983 serum_bileacids kegg 0.606 NA no no no no no no CA+blood GABAergic synapse 0 -0.551876529 0 serum_bileacids kegg 0.606 NA no no no no up up CA+blood GCDCA+stool 0 0 0.551530979 yes serum_bileacids stool_bileacids 0.606 0.0471 no no no no dn no CA+blood Glucagon signaling pathway 0 0.79028719 0.600776679 serum_bileacids kegg 0.606 NA no no no no no no CA+blood GnRH signaling pathway 0 0.65342181 0.471818189 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Graft-versus-host disease 0 -0.644591786 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood HIF-1 signaling pathway 0 0.722590335 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Human papillomavirus infection 0 -0.59308331 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Huntington disease 0 0.746137067 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood IL-17 signaling pathway 0 -0.562178224 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Inflammatory mediator regulation of TRP channels 0 0.744665397 0.547494428 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Influenza A 0 -0.559234883 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Insulin secretion 0 0 0.477995841 yes serum_bileacids kegg 0.606 NA no no no no up up CA+blood Insulin signaling pathway 0 0.77115547 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood L-Tryptophan+stool -0.565934066 0 0 serum_bileacids stool_cometabolism 0.606 0.557 no no no no no no CA+blood Legionellosis 0 0.544518175 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Lipid and atherosclerosis 0 -0.740250384 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Long-term potentiation 0 0.501839724 0 serum_bileacids kegg 0.606 NA no no no no no up CA+blood Lysosome 0 -0.678440213 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Melanogenesis 0 0.65342181 0.444018754 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Mitophagy - animal 0.499341865 0.713760311 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Morphine addiction 0 0 0.457146265 serum_bileacids kegg 0.606 NA no no no no up up CA+blood mRNA surveillance pathway 0 0.63281842 0.5204672 serum_bileacids kegg 0.606 NA no no no no no no CA+blood mTOR signaling pathway 0 0.835908983 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Natural killer cell mediated cytotoxicity 0 -0.547461517 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Neuroactive ligand-receptor interaction 0 -0.669610189 0 serum_bileacids kegg 0.606 NA no no no up up up CA+blood Neutrophil extracellular trap formation 0 -0.706401957 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Nicotinate and nicotinamide metabolism 0 -0.604856676 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood NOD-like receptor signaling pathway 0 -0.512141419 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Non-alcoholic fatty liver disease 0 0.73142036 0.484173493 serum_bileacids kegg 0.606 NA no no no no no no CA+blood nutriCA+stool 0 0 0.519711884 serum_bileacids stool_bileacids 0.606 0.481 no no no no no no CA+blood Olfactory transduction -0.477402415 -0.591611639 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Osteoclast differentiation 0 -0.610743359 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Oxidative phosphorylation 0 0.704930287 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Pancreatic secretion 0 0 0.422396971 serum_bileacids kegg 0.606 NA no no no no no no CA+blood "Parathyroid hormone synthesis, secretion and action" 0 0.816777263 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Parkinson disease 0 0.749080409 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Pathogenic Escherichia coli infection 0 -0.57247992 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Pathways of neurodegeneration - multiple diseases 0 0.769683799 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Peroxisome -0.46248359 -0.706401957 -0.416219319 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Pertussis 0 -0.722590335 -0.412358286 serum_bileacids kegg 0.606 NA no no no no no dn CA+blood Phagosome 0 -0.656365152 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Phosphatidylinositol signaling system 0 0 0.430119036 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Prion disease 0 0.746137067 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Prolactin signaling pathway 0 -0.504783065 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Protein processing in endoplasmic reticulum 0 0.625460066 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Proteoglycans in cancer 0.532689827 0.57395159 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Purine metabolism 0 0.551876529 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Ras signaling pathway 0 0 0.406180634 yes serum_bileacids kegg 0.606 NA no no no no up up CA+blood Renin secretion 0 0.562178224 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Retrograde endocannabinoid signaling 0 0.568064907 0.459462884 serum_bileacids kegg 0.606 NA no no no no no up CA+blood Rheumatoid arthritis 0 -0.668138518 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Ribosome 0 0.763797116 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Ribosome biogenesis in eukaryotes 0 0.509198078 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood RNA degradation 0 0.588668298 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood RNA transport 0 0.762325446 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Salmonella infection 0 -0.532744809 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Shigellosis 0.464238746 0.569536578 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Spinocerebellar ataxia 0 0.543046505 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Staphylococcus aureus infection 0 -0.73142036 -0.505023069 serum_bileacids kegg 0.606 NA no no no up no no CA+blood Systemic lupus erythematosus 0 -0.754967092 -0.416219319 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Thermogenesis 0 0.775570482 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Thyroid hormone synthesis 0 0.578366602 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Toxoplasmosis 0 -0.565121566 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Transcriptional misregulation in cancer 0 -0.498896382 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Tuberculosis 0 -0.700515274 -0.458690678 serum_bileacids kegg 0.606 NA no no no no no dn CA+blood Type I diabetes mellitus 0 -0.644591786 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Ubiquitin mediated proteolysis 0.511627956 0.743193726 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Vascular smooth muscle contraction 0 0.523914785 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Viral carcinogenesis 0 -0.576894932 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Viral myocarditis 0 -0.610743359 0 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Wnt signaling pathway 0 0.519499773 0.435524482 serum_bileacids kegg 0.606 NA no no no no no no CA+blood Yersinia infection 0 -0.709345299 0 serum_bileacids kegg 0.606 NA no no no no no no CA+stool 12-ketoDCA+stool -0.525283798 0 0 stool_bileacids stool_bileacids 0.827 0.505 no no no no no no CA+stool Aldosterone synthesis and secretion -0.519091847 0 0 stool_bileacids kegg 0.827 NA no no no no up up CA+stool Allograft rejection 0 0.690909091 0.551665726 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Alzheimer disease 0 0 0.556182947 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Amoebiasis 0.469556244 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Amphetamine addiction -0.678018576 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool AMPK signaling pathway 0 0 -0.465838509 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Amyotrophic lateral sclerosis 0 0 0.579898363 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Antigen processing and presentation 0.496388029 0 0.438735178 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Apoptosis 0.609907121 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Arginine and proline metabolism 0.492260062 0 0 stool_bileacids kegg 0.827 NA no no no no up no CA+stool Asthma 0 0.781818182 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Autoimmune thyroid disease 0 0.690909091 0.551665726 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Bacterial invasion of epithelial cells 0 0.618181818 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Bacteroides 0.671826625 0 0 LPS-producing stool_bileacids Genus 0.827 0.000267 no no no dn dn up CA+stool Bifidobacterium 0 0.587412587 0 acetate-producing stool_bileacids Genus 0.827 0.105 no no no no dn no CA+stool Biosynthesis of amino acids 0.626418989 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Blautia 0.479876161 0.636363636 0 acetate-producing stool_bileacids Genus 0.827 1.36E-05 no no no up dn dn CA+stool Butyric acid+stool -0.547987616 0 0 yes stool_bileacids stool_scfa 0.827 0.102 no no no dn no no CA+stool Carbon metabolism 0 0.818181818 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Cardiac muscle contraction 0 0 0.561829475 stool_bileacids kegg 0.827 NA no no no no no up CA+stool Cell adhesion molecules 0.484004128 0.681818182 0.470355731 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Cell cycle -0.523219814 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Cellular senescence 0.655314757 0 0.604743083 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Central carbon metabolism in cancer 0 0 -0.489553924 stool_bileacids kegg 0.827 NA no no no no no no CA+stool cGMP-PKG signaling pathway 0.506707946 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Chemical carcinogenesis - receptor activation -0.502579979 -0.709090909 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Chemokine signaling pathway 0.581011352 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Circadian entrainment -0.512899897 0 0 stool_bileacids kegg 0.827 NA no no no no up up CA+stool Clostridium 0 0.692307692 0 stool_bileacids Genus 0.827 0.925 no no no no no no CA+stool Cocaine addiction 0 -0.763636364 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Coprococcus 0 0 -0.596837945 butyrate-producing stool_bileacids Genus 0.827 0.612 no no no no no no CA+stool Coronavirus disease - COVID-19 -0.632610939 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Cortisol synthesis and secretion 0 -0.836363636 0 stool_bileacids kegg 0.827 NA no no no no no up CA+stool Cushing syndrome -0.647058824 -0.609090909 0 stool_bileacids kegg 0.827 NA no no no no no up CA+stool Diabetic cardiomyopathy 0 0 0.544889893 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Dorea 0 0.713286713 0 stool_bileacids Genus 0.827 0.00362 no no no up no dn CA+stool Endocrine resistance -0.595459236 -0.718181818 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Endocytosis 0.680082559 0.609090909 0.57312253 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Epithelial cell signaling in Helicobacter pylori infection 0.872033024 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Epstein-Barr virus infection 0.510835913 0 0.492941841 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Fc gamma R-mediated phagocytosis 0.620227038 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Ferroptosis 0 -0.7 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Focal adhesion 0 0.654545455 0 stool_bileacids kegg 0.827 NA no no no no up up CA+stool FoxO signaling pathway 0 0 -0.540372671 stool_bileacids kegg 0.827 NA no no no no no no CA+stool GABAergic synapse 0.543859649 0 0 stool_bileacids kegg 0.827 NA no no no no up up CA+stool Gap junction 0 -0.809090909 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Glucagon signaling pathway -0.607843137 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Glutamatergic synapse 0 -0.863636364 0 stool_bileacids kegg 0.827 NA no no no no up up CA+stool Glycolysis / Gluconeogenesis 0 0.781818182 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool GnRH signaling pathway 0 -0.672727273 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Graft-versus-host disease 0 0.690909091 0.5256917 stool_bileacids kegg 0.827 NA no no no no no no CA+stool "Growth hormone synthesis, secretion and action" 0 -0.818181818 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Hematopoietic cell lineage 0 0.690909091 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Hepatitis B 0.475748194 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Herpes simplex virus 1 infection 0 0 0.560700169 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Human cytomegalovirus infection 0 0 0.5256917 stool_bileacids kegg 0.827 NA no no no no no dn CA+stool Human immunodeficiency virus 1 infection 0 0 0.548277809 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Human papillomavirus infection 0.614035088 0 0.485036702 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Human T-cell leukemia virus 1 infection 0 0 0.513269339 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Huntington disease 0 0 0.555053642 stool_bileacids kegg 0.827 NA no no no no no no CA+stool IL-17 signaling pathway 0.671826625 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Inflammatory mediator regulation of TRP channels -0.490196078 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Insulin secretion 0 -0.745454545 0 yes stool_bileacids kegg 0.827 NA no no no no up up CA+stool Leukocyte transendothelial migration 0 0.609090909 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Lipid and atherosclerosis 0.706914345 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Long-term depression 0 -0.636363636 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Longevity regulating pathway 0 -0.663636364 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Longevity regulating pathway - multiple species 0 0.645454545 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Lysosome 0.657378741 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Melanogenesis -0.618163055 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Morphine addiction 0 -0.609090909 0 stool_bileacids kegg 0.827 NA no no no no up up CA+stool Natural killer cell mediated cytotoxicity 0.620227038 0.645454545 0.474872953 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Neutrophil extracellular trap formation 0.719298246 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool NF-kappa B signaling pathway 0.531475748 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool NOD-like receptor signaling pathway 0.609907121 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Non-alcoholic fatty liver disease 0 0 0.517786561 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Odoribacter 0 0.608391608 0 butyrate-producing stool_bileacids Genus 0.827 0.798 no no no no no no CA+stool Oocyte meiosis 0 0.609090909 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Osteoclast differentiation 0.756449948 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Oxidative phosphorylation 0 0 0.567476002 stool_bileacids kegg 0.827 NA no no no no no no CA+stool p53 signaling pathway 0 -0.645454545 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Parkinson disease -0.469556244 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Pathogenic Escherichia coli infection 0.605779154 0.618181818 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Pathways in cancer 0 -0.645454545 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Peroxisome 0.535603715 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Pertussis 0.708978328 0 0 stool_bileacids kegg 0.827 NA no no no no no dn CA+stool Phagosome 0.560371517 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Phospholipase D signaling pathway 0 -0.672727273 0 stool_bileacids kegg 0.827 NA no no no no up up CA+stool Prion disease 0 0 0.551665726 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Proteasome 0 0.836363636 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Protein processing in endoplasmic reticulum -0.492260062 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Regulation of actin cytoskeleton 0 0.681818182 0.462450593 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Regulation of lipolysis in adipocytes 0 -0.736363636 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Renin secretion -0.595459236 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Retrograde endocannabinoid signaling 0 0 0.642010164 stool_bileacids kegg 0.827 NA no no no no no up CA+stool Ribosome -0.64499484 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Ribosome biogenesis in eukaryotes -0.498452012 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool RIG-I-like receptor signaling pathway 0.587203302 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Roseburia 0 0 0.443675889 butyrate-producing stool_bileacids Genus 0.827 0.495 no no no no no no CA+stool Salmonella infection 0.494324045 0.745454545 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Serotonergic synapse 0 -0.909090909 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Systemic lupus erythematosus 0.475748194 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Thermogenesis -0.498452012 0 0.482778091 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Thyroid hormone synthesis -0.620227038 -0.672727273 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Toll-like receptor signaling pathway 0.523219814 0 0 yes stool_bileacids kegg 0.827 NA no no no no no no CA+stool Transcriptional misregulation in cancer 0.486068111 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Tuberculosis 0.512899897 0 0 stool_bileacids kegg 0.827 NA no no no no no dn CA+stool Type I diabetes mellitus 0 0.690909091 0.556182947 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Ubiquitin mediated proteolysis -0.484004128 0 0 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Viral carcinogenesis 0.651186791 0 0.527950311 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Viral myocarditis 0 0.690909091 0.579898363 stool_bileacids kegg 0.827 NA no no no no no no CA+stool Yersinia infection 0.547987616 0 0 stool_bileacids kegg 0.827 NA no no no no no no Calcium signaling pathway 2-Oxocarboxylic acid metabolism -0.562608696 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway ABC transporters -0.673913043 0 0 kegg kegg NA NA no up up no up up Calcium signaling pathway "Alanine, aspartate and glutamate metabolism" -0.434782609 -0.589920949 -0.581209781 kegg kegg NA NA no up up no no no Calcium signaling pathway alpha-Linolenic acid metabolism -0.88 -0.710474308 -0.570656371 kegg kegg NA NA no up up no no no Calcium signaling pathway Amino sugar and nucleotide sugar metabolism -0.836521739 -0.48715415 -0.588674389 kegg kegg NA NA no up up no no no Calcium signaling pathway Aminoacyl-tRNA biosynthesis -0.633043478 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Arginine and proline metabolism -0.617391304 -0.549407115 0 kegg kegg NA NA no up up no up no Calcium signaling pathway Arginine biosynthesis -0.486956522 -0.532608696 -0.558815959 kegg kegg NA NA no up up no no no Calcium signaling pathway beta-Alanine metabolism -0.78173913 -0.41798419 -0.642985843 kegg kegg NA NA no up up no no no Calcium signaling pathway Biosynthesis of amino acids -0.732173913 -0.592885375 -0.666666667 kegg kegg NA NA no up up no no no Calcium signaling pathway Biosynthesis of unsaturated fatty acids -0.513913043 -0.5 -0.403603604 kegg kegg NA NA no up up no no no Calcium signaling pathway Blautia 0 -0.494071146 0 acetate-producing kegg Genus NA 1.36E-05 no up up up dn dn Calcium signaling pathway Butanoate metabolism -0.643478261 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Butyricimonas 0.458112494 0 0 butyrate-producing kegg Genus NA 0.17 no up up no no no Calcium signaling pathway Carbon metabolism -0.731304348 0 -0.704761905 kegg kegg NA NA no up up no no no Calcium signaling pathway Citrate cycle (TCA cycle) -0.452173913 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Drug metabolism - other enzymes -0.68 0 -0.481595882 kegg kegg NA NA no up up no no no Calcium signaling pathway EGFR tyrosine kinase inhibitor resistance 0 0.458498024 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Endocrine resistance 0.644347826 0.516798419 0.543114543 kegg kegg NA NA no up up no no no Calcium signaling pathway ErbB signaling pathway 0.460869565 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Ether lipid metabolism 0.537391304 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Fatty acid biosynthesis 0 -0.591897233 -0.410810811 kegg kegg NA NA no up up no no no Calcium signaling pathway Fatty acid degradation -0.692173913 -0.798418972 -0.748777349 kegg kegg NA NA no up up no no no Calcium signaling pathway Fatty acid elongation -0.589565217 0 -0.425997426 kegg kegg NA NA no up up no no no Calcium signaling pathway Fatty acid metabolism -0.747826087 -0.851778656 -0.711969112 kegg kegg NA NA no up up no no no Calcium signaling pathway Fructose and mannose metabolism -0.863478261 0 -0.615958816 kegg kegg NA NA no up up no no no Calcium signaling pathway Galactose metabolism -0.852173913 -0.565217391 -0.45019305 kegg kegg NA NA no up up no no no Calcium signaling pathway Glutathione metabolism 0 0.507905138 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Glycolysis / Gluconeogenesis -0.719130435 0 -0.542857143 kegg kegg NA NA no up up no no no Calcium signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0.746956522 0.631422925 0.452509653 kegg kegg NA NA no up up no no no Calcium signaling pathway Glycosaminoglycan degradation 0 -0.467391304 0 kegg kegg NA NA no up up no no up Calcium signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.525217391 0 0.456370656 kegg kegg NA NA no up up no no no Calcium signaling pathway Glyoxylate and dicarboxylate metabolism -0.595652174 -0.556324111 -0.585585586 kegg kegg NA NA no up up no no no Calcium signaling pathway Histidine metabolism -0.714782609 -0.640316206 -0.685971686 kegg kegg NA NA no up up no no no Calcium signaling pathway Mannose type O-glycan biosynthesis 0.57826087 0 0.40952381 kegg kegg NA NA no up up no no no Calcium signaling pathway MAPK signaling pathway 0 -0.62944664 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Metabolism of xenobiotics by cytochrome P450 -0.443478261 0 -0.402831403 kegg kegg NA NA no up up no no no Calcium signaling pathway Mismatch repair -0.424347826 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway mRNA surveillance pathway 0.654782609 0.583003953 0.621879022 kegg kegg NA NA no up up no no no Calcium signaling pathway Mucin type O-glycan biosynthesis 0 -0.437747036 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Nicotinate and nicotinamide metabolism -0.453913043 -0.505928854 -0.422136422 kegg kegg NA NA no up up no no no Calcium signaling pathway Non-homologous end-joining -0.637391304 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Oscillospira 0 -0.476284585 0 LPS-producing kegg Genus NA 0.62 no up up no no no Calcium signaling pathway Other glycan degradation -0.649565217 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Oxidative phosphorylation 0.679130435 0.736166008 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Pantothenate and CoA biosynthesis 0 -0.710474308 -0.632432432 kegg kegg NA NA no up up no no dn Calcium signaling pathway Pentose phosphate pathway -0.516521739 -0.46541502 -0.645559846 kegg kegg NA NA no up up no no no Calcium signaling pathway Phenylalanine metabolism -0.436521739 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway PPAR signaling pathway 0 -0.4743083 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Prevotella 0 0 0.487431749 acetate-producing kegg Genus NA 0.287 no up up no no no Calcium signaling pathway Primary bile acid biosynthesis -0.516521739 0 -0.530501931 kegg kegg NA NA no up up no no no Calcium signaling pathway Propanoate metabolism -0.507826087 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Protein export 0.490434783 0 0.411583012 kegg kegg NA NA no up up no no no Calcium signaling pathway Pyrimidine metabolism -0.772173913 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Pyruvate metabolism -0.459130435 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Rap1 signaling pathway 0 0.479249012 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Ras signaling pathway 0.552173913 0.418972332 0 yes kegg kegg NA NA no up up no up up Calcium signaling pathway Retinol metabolism -0.646086957 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Ribosome 0.591304348 0.616600791 0 kegg kegg NA NA no up up no no no Calcium signaling pathway RNA degradation 0.700869565 0.530632411 0.477220077 kegg kegg NA NA no up up no no no Calcium signaling pathway Spliceosome 0 0 0.401801802 kegg kegg NA NA no up up no no no Calcium signaling pathway Starch and sucrose metabolism -0.795652174 -0.675889328 -0.645302445 kegg kegg NA NA no up up no no no Calcium signaling pathway Steroid hormone biosynthesis -0.547826087 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Sulfur metabolism 0 0 -0.404375804 kegg kegg NA NA no up up no no no Calcium signaling pathway Thiamine metabolism -0.579130435 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway Tryptophan metabolism -0.668695652 0 -0.433719434 kegg kegg NA NA no up up no up no Calcium signaling pathway Tyrosine metabolism -0.48 0 -0.514285714 kegg kegg NA NA no up up no no no Calcium signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.607826087 0 0 kegg kegg NA NA no up up no no no Calcium signaling pathway "Valine, leucine and isoleucine degradation" -0.580869565 0 0 kegg kegg NA NA no up up no no no cAMP signaling pathway 2-Oxocarboxylic acid metabolism -0.794782609 -0.557312253 -0.652767053 yes kegg kegg NA NA no up up no no no cAMP signaling pathway ABC transporters -0.544347826 0 0 yes kegg kegg NA NA no up up no up up cAMP signaling pathway alpha-Linolenic acid metabolism -0.700869565 0 -0.717631918 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Amino sugar and nucleotide sugar metabolism -0.677391304 -0.505928854 -0.662290862 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Aminoacyl-tRNA biosynthesis -0.719130435 -0.661067194 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Antifolate resistance 0 -0.499011858 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Arachidonic acid metabolism -0.422608696 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Ascorbate and aldarate metabolism 0 0 -0.566023166 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Bacteroides -0.415652174 -0.520750988 0 yes LPS-producing kegg Genus NA 0.000267 no up up dn dn up cAMP signaling pathway Basal transcription factors 0 -0.518774704 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Base excision repair 0 -0.615612648 -0.449163449 yes kegg kegg NA NA no up up no no no cAMP signaling pathway beta-Alanine metabolism -0.922608696 -0.693675889 -0.798455598 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Biosynthesis of amino acids -0.750434783 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Biosynthesis of cofactors -0.470434783 -0.464426877 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Biosynthesis of unsaturated fatty acids -0.626956522 -0.690711462 -0.636808237 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Butanoate metabolism -0.862608696 -0.747035573 -0.637580438 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Butyricimonas 0.521205831 0 0 yes butyrate-producing kegg Genus NA 0.17 no up up no no no cAMP signaling pathway Calcium signaling pathway 0.735652174 0 0.66023166 yes kegg kegg NA NA no up up no up up cAMP signaling pathway Carbon metabolism -0.812173913 0 -0.493178893 yes kegg kegg NA NA no up up no no no cAMP signaling pathway cGMP-PKG signaling pathway 0.464347826 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Citrate cycle (TCA cycle) -0.635652174 -0.769762846 -0.626512227 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Clostridium 0 -0.416691439 0 yes kegg Genus NA 0.925 no up up no no no cAMP signaling pathway Cysteine and methionine metabolism 0 -0.750988142 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway DNA replication 0 -0.781620553 -0.442985843 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Drug metabolism - cytochrome P450 0 -0.714426877 -0.601544402 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Drug metabolism - other enzymes -0.760869565 -0.550395257 -0.433204633 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Endocrine resistance 0.49826087 0 0.608236808 yes kegg kegg NA NA no up up no no no cAMP signaling pathway ErbB signaling pathway 0.405217391 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Ether lipid metabolism 0.535652174 0 -0.404118404 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Fanconi anemia pathway 0 -0.623517787 -0.404890605 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Fatty acid degradation -0.656521739 0 -0.59047619 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Fatty acid elongation -0.72173913 -0.648221344 -0.643500644 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Fatty acid metabolism -0.746086957 0 -0.547747748 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Fructose and mannose metabolism -0.791304348 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Galactose metabolism -0.792173913 0 -0.497554698 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Glycolysis / Gluconeogenesis -0.796521739 -0.589920949 -0.594337194 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.480237154 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.530434783 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0.431304348 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 -0.604743083 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.444347826 0.451581028 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Glyoxylate and dicarboxylate metabolism -0.520869565 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Histidine metabolism -0.608695652 -0.43972332 -0.684684685 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Homologous recombination 0 -0.41798419 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Mannose type O-glycan biosynthesis 0.415652174 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Metabolism of xenobiotics by cytochrome P450 -0.42173913 -0.709486166 -0.608494208 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Mismatch repair -0.509565217 -0.868577075 -0.496782497 yes kegg kegg NA NA no up up no no no cAMP signaling pathway mRNA surveillance pathway 0.706956522 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway N-Glycan biosynthesis 0 -0.491106719 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Non-homologous end-joining -0.813913043 -0.821146245 -0.595109395 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Nucleotide excision repair 0 -0.791501976 -0.467696268 yes kegg kegg NA NA no up up no no no cAMP signaling pathway One carbon pool by folate 0 -0.748023715 -0.411840412 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Other glycan degradation 0 0 -0.427541828 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Oxidative phosphorylation 0.746956522 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Pentose and glucuronate interconversions 0 -0.605731225 -0.479021879 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Phenylalanine metabolism -0.640869565 -0.677865613 -0.462548263 yes kegg kegg NA NA no up up no no no cAMP signaling pathway PPAR signaling pathway 0 0.415019763 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Prevotella 0 0 0.517684184 yes acetate-producing kegg Genus NA 0.287 no up up no no no cAMP signaling pathway Primary bile acid biosynthesis -0.632173913 -0.696640316 -0.505534106 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Propanoate metabolism -0.470434783 -0.748023715 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Proteasome 0 -0.580039526 -0.423166023 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Protein export 0.413913043 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Pyrimidine metabolism -0.811304348 -0.654150198 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Pyruvate metabolism -0.516521739 -0.698616601 -0.421364221 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Retinol metabolism -0.597391304 -0.774703557 -0.667438867 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Ribosome 0.553043478 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Ribosome biogenesis in eukaryotes 0 -0.626482213 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway RNA degradation 0.627826087 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway RNA polymerase 0 -0.518774704 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Selenocompound metabolism 0 -0.447628458 -0.472329472 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Starch and sucrose metabolism -0.420869565 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Steroid biosynthesis 0 -0.820158103 -0.579150579 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Steroid hormone biosynthesis -0.48 -0.743083004 -0.457400257 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Sulfur metabolism -0.491304348 0 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Synthesis and degradation of ketone bodies -0.443478261 -0.813241107 -0.495495495 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Terpenoid backbone biosynthesis 0 -0.646245059 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Thiamine metabolism 0 -0.467391304 0 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Tryptophan metabolism -0.852173913 -0.817193676 -0.641956242 yes kegg kegg NA NA no up up no up no cAMP signaling pathway Tyrosine metabolism -0.634782609 -0.790513834 -0.701930502 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.677391304 -0.818181818 -0.453024453 yes kegg kegg NA NA no up up no no no cAMP signaling pathway "Valine, leucine and isoleucine degradation" -0.740869565 -0.756916996 -0.723037323 yes kegg kegg NA NA no up up no no no cAMP signaling pathway Various types of N-glycan biosynthesis 0 -0.486166008 0 yes kegg kegg NA NA no up up no no no capric acid C6+blood 16:0-LPC+blood 0 0 -0.401709402 serum_scfa serum_phospholipids 0.433 0.00456 no no no up up no capric acid C6+blood 16:0-LPE+blood 0 0 -0.48034188 serum_scfa serum_phospholipids 0.433 0.0711 no no no up up no capric acid C6+blood 16:0/16:0-PI+blood 0 0 -0.576752137 serum_scfa serum_phospholipids 0.433 0.358 no no no no no no capric acid C6+blood 16:0/16:1-PI+blood 0 0 -0.645128205 serum_scfa serum_phospholipids 0.433 0.262 no no no no no no capric acid C6+blood 16:0/18:2-PI+blood 0 0 -0.659487179 serum_scfa serum_phospholipids 0.433 0.269 no no no no no no capric acid C6+blood 16:0/20:4-PI+blood 0 0 -0.579487179 serum_scfa serum_phospholipids 0.433 0.558 no no no no no no capric acid C6+blood 16:1/18:1-PG+blood 0 0.490196078 0 serum_scfa serum_phospholipids 0.433 3.21E-05 no no no no up up capric acid C6+blood 18:0-LPA+blood 0 0.779411765 0 serum_scfa serum_phospholipids 0.433 0.0725 no no no no dn no capric acid C6+blood 18:0-LPE+blood 0 0 -0.422905983 serum_scfa serum_phospholipids 0.433 0.491 no no no no no no capric acid C6+blood 18:0/18:2-PI+blood 0 0 -0.541880342 serum_scfa serum_phospholipids 0.433 0.179 no no no no no no capric acid C6+blood 18:1-LPC+blood 0.506766917 0 0 serum_scfa serum_phospholipids 0.433 0.179 no no no no no no capric acid C6+blood 18:1-LPE+blood 0 0 -0.407863248 serum_scfa serum_phospholipids 0.433 0.117 no no no no no no capric acid C6+blood 18:1/16:0-PI+blood 0 0.49754902 -0.447521368 serum_scfa serum_phospholipids 0.433 0.793 no no no no no no capric acid C6+blood 18:1/18:0-PI+blood 0 0 -0.553504274 serum_scfa serum_phospholipids 0.433 0.0931 no no no no no up capric acid C6+blood 18:1/22:6-PE+blood 0 0 0.411282051 serum_scfa serum_phospholipids 0.433 0.0047 no no no no up no capric acid C6+blood 18:2-LPE+blood 0 0 -0.526837607 serum_scfa serum_phospholipids 0.433 0.112 no no no no no no capric acid C6+blood 18:3/16:0-PE+blood 0 0 -0.514529915 serum_scfa serum_phospholipids 0.433 0.00149 no no no up up no capric acid C6+blood 18:3n6+blood 0 0 -0.531623932 serum_scfa serum_fattyacid 0.433 0.0463 no no no up no dn capric acid C6+blood 20:0+blood 0.615037594 0 -0.632820513 yes serum_scfa serum_fattyacid 0.433 0.000278 no no no dn no up capric acid C6+blood 20:1-LPA+blood 0 0.735294118 0 serum_scfa serum_phospholipids 0.433 0.0187 no no no dn dn no capric acid C6+blood 20:1-LPC+blood 0.634586466 0 0 serum_scfa serum_phospholipids 0.433 0.217 no no no no no no capric acid C6+blood 20:1-LPE+blood 0.666165414 0 0 serum_scfa serum_phospholipids 0.433 0.465 no no no no no no capric acid C6+blood 20:2-LPE+blood 0.642105263 0 0 serum_scfa serum_phospholipids 0.433 0.177 no no no no no no capric acid C6+blood 20:4-LPA+blood 0 0.495098039 0 serum_scfa serum_phospholipids 0.433 0.398 no no no no no no capric acid C6+blood 22:1-LPA+blood 0 0.551470588 0 serum_scfa serum_phospholipids 0.433 0.00373 no no no no up up capric acid C6+blood 22:2-LPA+blood 0 0.612745098 0 serum_scfa serum_phospholipids 0.433 0.0443 no no no dn no no capric acid C6+blood 24:1+blood -0.511278195 0 0 serum_scfa serum_fattyacid 0.433 0.00582 no no no no dn dn capric acid C6+blood acetic acid C2+blood 0 0 0.453675214 serum_scfa serum_scfa 0.433 0.000193 no no no up dn no capric acid C6+blood CA+blood 0 0 -0.461409233 serum_scfa serum_bileacids 0.433 0.606 no no no no no no Carbohydrate digestion and absorption 2-Oxocarboxylic acid metabolism -0.426086957 0 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption ABC transporters 0 0.516798419 0 kegg kegg NA NA no no no no up up Carbohydrate digestion and absorption Adherens junction -0.583478261 -0.469367589 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption AGE-RAGE signaling pathway in diabetic complications 0.519130435 0.622529644 0.554954955 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption "Alanine, aspartate and glutamate metabolism" 0.448695652 0 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Aldosterone-regulated sodium reabsorption 0.757391304 0.759881423 0.783526384 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Amino sugar and nucleotide sugar metabolism 0 0 0.415701416 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Antigen processing and presentation 0 -0.441699605 -0.440669241 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Apelin signaling pathway 0 -0.539525692 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Apoptosis 0 0.441699605 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Apoptosis - multiple species 0 0 0.439382239 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Arachidonic acid metabolism -0.589565217 0 -0.43989704 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Ascorbate and aldarate metabolism -0.522608696 -0.471343874 0.506306306 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Autophagy - animal 0.790434783 0.654150198 0.775289575 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Autophagy - other 0.579130435 0.416007905 0.526383526 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption B cell receptor signaling pathway 0 0.536561265 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption beta-Alanine metabolism -0.476521739 -0.58201581 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Biosynthesis of cofactors -0.603478261 0 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Biosynthesis of unsaturated fatty acids -0.453043478 -0.56027668 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Butanoate metabolism -0.470434783 -0.555335968 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption C-type lectin receptor signaling pathway 0.76173913 0.596837945 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Cellular senescence 0 0.423913043 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Cholinergic synapse 0.739130435 0 0.642728443 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Circadian entrainment 0 -0.539525692 -0.536679537 kegg kegg NA NA no no no no up up Carbohydrate digestion and absorption Circadian rhythm 0.43826087 0 0.436550837 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Citrate cycle (TCA cycle) -0.530434783 -0.657114625 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Collecting duct acid secretion -0.410434783 0 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Cysteine and methionine metabolism 0 -0.575098814 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption DNA replication 0 -0.421936759 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Dopaminergic synapse 0 -0.435770751 0 kegg kegg NA NA no no no no up no Carbohydrate digestion and absorption Drug metabolism - cytochrome P450 -0.405217391 -0.614624506 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Drug metabolism - other enzymes -0.512173913 -0.622529644 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption ErbB signaling pathway 0.804347826 0.937747036 0.777091377 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Estrogen signaling pathway 0 -0.520750988 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Fatty acid biosynthesis 0.450434783 0.443675889 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Fatty acid elongation -0.569565217 -0.595849802 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Fc epsilon RI signaling pathway 0.52 0.624505929 0.561904762 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Ferroptosis 0 0 -0.526640927 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Focal adhesion -0.472173913 -0.527667984 0 kegg kegg NA NA no no no no up up Carbohydrate digestion and absorption FoxO signaling pathway 0.584347826 0.611660079 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Fructose and mannose metabolism 0 0.539525692 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Galactose metabolism 0 0.529644269 0.565250965 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Gap junction 0 0 -0.48030888 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Gastric acid secretion -0.595652174 -0.523715415 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Glutamatergic synapse 0 0 -0.451480051 kegg kegg NA NA no no no no up up Carbohydrate digestion and absorption Glutathione metabolism -0.475652174 -0.4743083 -0.534105534 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Glycerolipid metabolism 0 0.587944664 0.600772201 kegg kegg NA NA no no no no no up Carbohydrate digestion and absorption Glycerophospholipid metabolism 0 0 0.622651223 kegg kegg NA NA no no no no no up Carbohydrate digestion and absorption "Glycine, serine and threonine metabolism" -0.486956522 0 0 kegg kegg NA NA no no no no up no Carbohydrate digestion and absorption Glycolysis / Gluconeogenesis 0 -0.640316206 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.447826087 0.777667984 0.553925354 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.512173913 0 0.445302445 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Glycosaminoglycan degradation 0 0 0.550836551 kegg kegg NA NA no no no no no up Carbohydrate digestion and absorption Glycosphingolipid biosynthesis - ganglio series -0.448695652 0 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Glycosphingolipid biosynthesis - globo and isoglobo series -0.432173913 0 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption GnRH secretion 0.784347826 0.93972332 0.82960103 kegg kegg NA NA no no no no up up Carbohydrate digestion and absorption "Growth hormone synthesis, secretion and action" 0.615652174 0.65513834 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Hedgehog signaling pathway 0 0 0.606949807 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption HIF-1 signaling pathway 0 -0.462450593 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Hippo signaling pathway -0.62173913 -0.432806324 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Hippo signaling pathway - multiple species 0 0 0.65997426 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Histidine metabolism -0.408695652 0 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption IL-17 signaling pathway 0.42173913 0 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Inositol phosphate metabolism 0 0.470355731 0.688803089 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Insulin resistance 0.689565217 0.752964427 0.462805663 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Insulin signaling pathway 0 -0.480237154 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption JAK-STAT signaling pathway 0 0.682806324 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Linoleic acid metabolism -0.474782609 0 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Long-term potentiation 0 -0.490118577 0 kegg kegg NA NA no no no no no up Carbohydrate digestion and absorption Lysine degradation 0 0 0.627284427 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Mannose type O-glycan biosynthesis 0 0.43972332 0.512741313 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption MAPK signaling pathway 0 0 0.635006435 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Maturity onset diabetes of the young 0 0 0.476705277 kegg kegg NA NA no no no no up no Carbohydrate digestion and absorption Metabolism of xenobiotics by cytochrome P450 -0.455652174 -0.664031621 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Mismatch repair -0.448695652 -0.498023715 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Mitophagy - animal 0 0 -0.552638353 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Necroptosis 0 0 -0.541827542 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Neurotrophin signaling pathway 0.622608696 0.576086957 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption NF-kappa B signaling pathway 0.570434783 0.650197628 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Nicotinate and nicotinamide metabolism 0 0.441699605 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption NOD-like receptor signaling pathway 0 0.483201581 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Non-alcoholic fatty liver disease 0 -0.433794466 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Non-homologous end-joining -0.411304348 -0.545454545 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Notch signaling pathway 0 0.628458498 0.614157014 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Nucleotide excision repair 0 -0.415019763 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Oocyte meiosis 0 -0.580039526 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Osteoclast differentiation 0 0.448616601 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Other glycan degradation 0 0.416996047 0.706306306 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Other types of O-glycan biosynthesis 0 0 0.607207207 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Ovarian steroidogenesis 0 0 -0.465894466 kegg kegg NA NA no no no no up up Carbohydrate digestion and absorption Oxidative phosphorylation 0 -0.469367589 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Oxytocin signaling pathway -0.5 -0.446640316 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption p53 signaling pathway 0.467826087 0 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Pentose and glucuronate interconversions -0.702608696 -0.561264822 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Phenylalanine metabolism -0.668695652 -0.554347826 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Phosphatidylinositol signaling system 0 0 0.609266409 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Phospholipase D signaling pathway 0 0.606719368 0 kegg kegg NA NA no no no no up up Carbohydrate digestion and absorption Phototransduction 0 -0.767786561 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Platelet activation -0.559130435 -0.451581028 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Platinum drug resistance 0.47826087 0.455533597 0.524324324 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Porphyrin and chlorophyll metabolism 0 0 -0.435006435 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Primary bile acid biosynthesis -0.526086957 -0.644268775 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Progesterone-mediated oocyte maturation 0.649565217 0.446640316 0.665122265 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Prolactin signaling pathway 0.749565217 0.709486166 0.524839125 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Propanoate metabolism 0 -0.591897233 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Proteasome 0 -0.661067194 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Protein export 0 -0.559288538 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Protein processing in endoplasmic reticulum 0 -0.419960474 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Proximal tubule bicarbonate reclamation 0 -0.441699605 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Pyruvate metabolism 0 -0.616600791 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Regulation of actin cytoskeleton -0.565217391 -0.62055336 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Relaxin signaling pathway 0.50173913 0.463438735 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Renin secretion -0.463478261 -0.558300395 -0.501673102 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Retrograde endocannabinoid signaling 0 -0.542490119 0 kegg kegg NA NA no no no no no up Carbohydrate digestion and absorption Ribosome 0 -0.4743083 -0.447619048 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption RIG-I-like receptor signaling pathway 0.759130435 0.605731225 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Selenocompound metabolism 0 0 0.544658945 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Serotonergic synapse 0 0 -0.422651223 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Signaling pathways regulating pluripotency of stem cells 0.59826087 0.70256917 0.638095238 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Sphingolipid metabolism 0 0 0.526640927 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Sphingolipid signaling pathway 0.613913043 0.462450593 0.578378378 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Steroid biosynthesis 0 -0.577075099 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Steroid hormone biosynthesis -0.643478261 -0.483201581 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Sulfur metabolism -0.572173913 -0.41798419 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption T cell receptor signaling pathway 0.550434783 0.480237154 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Taste transduction 0 0 0.601544402 kegg kegg NA NA no no no no no up Carbohydrate digestion and absorption Taurine and hypotaurine metabolism 0.426086957 0.722332016 0.467438867 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption TGF-beta signaling pathway 0 -0.490118577 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Thermogenesis 0 -0.481225296 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Thiamine metabolism 0 -0.550395257 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Thyroid hormone synthesis 0 0 -0.476705277 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Tight junction -0.694782609 -0.591897233 -0.462548263 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption TNF signaling pathway 0.808695652 0.68972332 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Toll-like receptor signaling pathway 0.831304348 0.518774704 0 yes kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Tryptophan metabolism -0.539130435 -0.621541502 0 kegg kegg NA NA no no no no up no Carbohydrate digestion and absorption Type II diabetes mellitus 0.895652174 0.908102767 0.840926641 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Tyrosine metabolism -0.605217391 -0.554347826 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Ubiquinone and other terpenoid-quinone biosynthesis -0.576521739 -0.473320158 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Ubiquitin mediated proteolysis 0 0 -0.56962677 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption "Valine, leucine and isoleucine degradation" -0.48 -0.564229249 0 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Vascular smooth muscle contraction 0 -0.587944664 -0.518918919 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Vasopressin-regulated water reabsorption 0 0 -0.508880309 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption VEGF signaling pathway 0.695652174 0.808300395 0.57966538 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Viral protein interaction with cytokine and cytokine receptor 0 0 -0.628571429 kegg kegg NA NA no no no no no no Carbohydrate digestion and absorption Wnt signaling pathway 0 0 0.411068211 kegg kegg NA NA no no no no no no Carbon metabolism "Alanine, aspartate and glutamate metabolism" 0 0 0.458687259 kegg kegg NA NA no no no no no no Carbon metabolism alpha-Linolenic acid metabolism 0.78 0 0.482110682 kegg kegg NA NA no no no no no no Carbon metabolism Amino sugar and nucleotide sugar metabolism 0.726956522 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Aminoacyl-tRNA biosynthesis 0.545217391 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Arginine biosynthesis 0 0 0.507850708 kegg kegg NA NA no no no no no no Carbon metabolism beta-Alanine metabolism 0.892173913 0.665019763 0.63037323 kegg kegg NA NA no no no no no no Carbon metabolism Biosynthesis of unsaturated fatty acids 0.52173913 0.448616601 0 kegg kegg NA NA no no no no no no Carbon metabolism Butanoate metabolism 0.786086957 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Citrate cycle (TCA cycle) 0.626956522 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Clostridium 0 0.662223558 0 kegg Genus NA 0.925 no no no no no no Carbon metabolism Dorea 0 0.434890055 0 kegg Genus NA 0.00362 no no no up no dn Carbon metabolism Drug metabolism - cytochrome P450 0 0 0.448906049 kegg kegg NA NA no no no no no no Carbon metabolism Drug metabolism - other enzymes 0.857391304 0.421936759 0 kegg kegg NA NA no no no no no no Carbon metabolism Ether lipid metabolism -0.555652174 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Fatty acid degradation 0.535652174 0 0.595881596 kegg kegg NA NA no no no no no no Carbon metabolism Fatty acid elongation 0.759130435 0.738142292 0.506048906 kegg kegg NA NA no no no no no no Carbon metabolism Fructose and mannose metabolism 0.797391304 0 0.516344916 kegg kegg NA NA no no no no no no Carbon metabolism Galactose metabolism 0.750434783 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Glycerolipid metabolism 0 -0.429841897 0 kegg kegg NA NA no no no no no up Carbon metabolism Glycerophospholipid metabolism 0 -0.630434783 0 kegg kegg NA NA no no no no no up Carbon metabolism Glycolysis / Gluconeogenesis 0.9 0.703557312 0.774517375 kegg kegg NA NA no no no no no no Carbon metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.680869565 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.495652174 0 -0.593822394 kegg kegg NA NA no no no no no no Carbon metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.503478261 0 -0.438867439 kegg kegg NA NA no no no no no no Carbon metabolism Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.541501976 -0.453281853 kegg kegg NA NA no no no no no no Carbon metabolism Glyoxylate and dicarboxylate metabolism 0 0 0.590733591 kegg kegg NA NA no no no no no no Carbon metabolism Histidine metabolism 0.503478261 0 0.578120978 kegg kegg NA NA no no no no no no Carbon metabolism Inositol phosphate metabolism 0 -0.427865613 0 kegg kegg NA NA no no no no no no Carbon metabolism Lachnospira 0 0.434890055 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Carbon metabolism Lysine degradation 0 -0.56027668 -0.474903475 kegg kegg NA NA no no no no no no Carbon metabolism Mannose type O-glycan biosynthesis -0.575652174 -0.518774704 -0.544144144 kegg kegg NA NA no no no no no no Carbon metabolism Metabolism of xenobiotics by cytochrome P450 0.513043478 0 0.520978121 kegg kegg NA NA no no no no no no Carbon metabolism Nicotinate and nicotinamide metabolism 0 0 0.557271557 kegg kegg NA NA no no no no no no Carbon metabolism Odoribacter 0 0.634474457 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Carbon metabolism Other types of O-glycan biosynthesis -0.495652174 -0.711462451 -0.501158301 kegg kegg NA NA no no no no no no Carbon metabolism Oxidative phosphorylation -0.722608696 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Pantothenate and CoA biosynthesis 0 0 0.709395109 kegg kegg NA NA no no no no no dn Carbon metabolism Parabacteroides 0.468695652 0 0 kegg Genus NA 4.19E-05 no no no no up up Carbon metabolism Paraprevotella 0.458257827 0 0 kegg Genus NA 0.118 no no no no no no Carbon metabolism Pentose and glucuronate interconversions 0.453913043 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Pentose phosphate pathway 0.605217391 0.574110672 0.796911197 kegg kegg NA NA no no no no no no Carbon metabolism Phenylalanine metabolism 0.664347826 0.462450593 0 kegg kegg NA NA no no no no no no Carbon metabolism Prevotella 0 0 -0.403035939 acetate-producing kegg Genus NA 0.287 no no no no no no Carbon metabolism Primary bile acid biosynthesis 0.537391304 0.66798419 0.6 kegg kegg NA NA no no no no no no Carbon metabolism Propanoate metabolism 0.474782609 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Pyramidobacter 0 0 -0.425454098 kegg Genus NA 0.45 no no no no no no Carbon metabolism Pyrimidine metabolism 0.688695652 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Pyruvate metabolism 0.419130435 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Retinol metabolism 0.65826087 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Starch and sucrose metabolism 0.51826087 0 0.512741313 kegg kegg NA NA no no no no no no Carbon metabolism Steroid hormone biosynthesis 0.53826087 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Sulfur metabolism 0.512173913 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Taurine and hypotaurine metabolism -0.45826087 -0.707509881 -0.456113256 kegg kegg NA NA no no no no no no Carbon metabolism Tryptophan metabolism 0.772173913 0.614624506 0.423166023 kegg kegg NA NA no no no no up no Carbon metabolism Tyrosine metabolism 0.615652174 0 0 kegg kegg NA NA no no no no no no Carbon metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.508695652 0 0 kegg kegg NA NA no no no no no no Carbon metabolism "Valine, leucine and isoleucine degradation" 0.620869565 0 0 kegg kegg NA NA no no no no no no Cardiac muscle contraction 2-Oxocarboxylic acid metabolism -0.58 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction ABC transporters -0.429565217 0 0 kegg kegg NA NA no no up no up up Cardiac muscle contraction "Alanine, aspartate and glutamate metabolism" -0.546086957 -0.790513834 -0.585585586 kegg kegg NA NA no no up no no no Cardiac muscle contraction alpha-Linolenic acid metabolism -0.629565217 -0.723320158 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Amino sugar and nucleotide sugar metabolism -0.597391304 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Aminoacyl-tRNA biosynthesis -0.607826087 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Apoptosis 0 -0.52173913 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Apoptosis - multiple species 0 -0.451581028 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Arginine and proline metabolism 0 -0.811264822 -0.596396396 kegg kegg NA NA no no up no up no Cardiac muscle contraction Arginine biosynthesis -0.553913043 -0.743083004 -0.537709138 kegg kegg NA NA no no up no no no Cardiac muscle contraction Autophagy - animal 0 -0.714426877 -0.444787645 kegg kegg NA NA no no up no no no Cardiac muscle contraction beta-Alanine metabolism -0.715652174 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Biosynthesis of amino acids -0.775652174 -0.653162055 -0.453796654 kegg kegg NA NA no no up no no no Cardiac muscle contraction Biosynthesis of unsaturated fatty acids -0.409565217 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Butanoate metabolism -0.624347826 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Butyricimonas 0 0 -0.422068072 butyrate-producing kegg Genus NA 0.17 no no up no no no Cardiac muscle contraction Calcium signaling pathway 0.731304348 0.770750988 0 kegg kegg NA NA no no up no up up Cardiac muscle contraction cAMP signaling pathway 0.770434783 0 0 yes kegg kegg NA NA no no up no up up Cardiac muscle contraction Carbon metabolism -0.749565217 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction cGMP-PKG signaling pathway 0 -0.64229249 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Chemokine signaling pathway 0 -0.414031621 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Cysteine and methionine metabolism 0 0.451581028 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Cytokine-cytokine receptor interaction 0 -0.446640316 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction DNA replication 0 0.45256917 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Drug metabolism - cytochrome P450 0 0.485177866 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Drug metabolism - other enzymes -0.583478261 0.527667984 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction EGFR tyrosine kinase inhibitor resistance 0 0.670948617 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Endocytosis -0.413913043 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Ether lipid metabolism 0.632173913 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Fatty acid biosynthesis -0.427826087 -0.792490119 -0.594594595 kegg kegg NA NA no no up no no no Cardiac muscle contraction Fatty acid degradation -0.659130435 -0.858695652 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Fatty acid elongation -0.507826087 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Fatty acid metabolism -0.745217391 -0.851778656 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Folate biosynthesis 0 0.459486166 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction FoxO signaling pathway 0 -0.713438735 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Fructose and mannose metabolism -0.759130435 -0.537549407 -0.54954955 kegg kegg NA NA no no up no no no Cardiac muscle contraction Galactose metabolism -0.727826087 -0.677865613 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Glutathione metabolism 0 0.603754941 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Glycerolipid metabolism 0 -0.533596838 0 kegg kegg NA NA no no up no no up Cardiac muscle contraction Glycolysis / Gluconeogenesis -0.62173913 0.428853755 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.692687747 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Glycosaminoglycan biosynthesis - keratan sulfate 0.506956522 0.458498024 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Glycosaminoglycan degradation 0 -0.435770751 0 kegg kegg NA NA no no up no no up Cardiac muscle contraction Glyoxylate and dicarboxylate metabolism -0.694782609 -0.75 -0.596396396 kegg kegg NA NA no no up no no no Cardiac muscle contraction HIF-1 signaling pathway 0 0.634387352 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Inositol phosphate metabolism 0 -0.416996047 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Mannose type O-glycan biosynthesis 0.442608696 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction MAPK signaling pathway 0 -0.656126482 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Metabolism of xenobiotics by cytochrome P450 0 0.440711462 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Mitophagy - animal 0.465217391 0.761857708 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction mRNA surveillance pathway 0.662608696 0.635375494 0.413384813 kegg kegg NA NA no no up no no no Cardiac muscle contraction mTOR signaling pathway 0 0.641304348 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Mucin type O-glycan biosynthesis 0 -0.444664032 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction N-Glycan biosynthesis 0 0.56916996 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Neuroactive ligand-receptor interaction 0 -0.533596838 0 kegg kegg NA NA no no up up up up Cardiac muscle contraction NF-kappa B signaling pathway 0 -0.699604743 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Nicotinate and nicotinamide metabolism -0.424347826 -0.726284585 -0.532303732 kegg kegg NA NA no no up no no no Cardiac muscle contraction Nitrogen metabolism -0.450434783 -0.66798419 -0.476962677 kegg kegg NA NA no no up no no no Cardiac muscle contraction Non-homologous end-joining -0.629565217 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Oocyte meiosis 0 0 0.40952381 kegg kegg NA NA no no up no no no Cardiac muscle contraction Oscillospira 0 -0.5 0 LPS-producing kegg Genus NA 0.62 no no up no no no Cardiac muscle contraction Other glycan degradation 0 -0.43972332 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Oxidative phosphorylation 0.97826087 0.979249012 0.972200772 kegg kegg NA NA no no up no no no Cardiac muscle contraction Pantothenate and CoA biosynthesis 0 -0.786561265 -0.555727156 kegg kegg NA NA no no up no no dn Cardiac muscle contraction Pentose and glucuronate interconversions 0 0.518774704 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Pentose phosphate pathway -0.471304348 -0.543478261 -0.533075933 kegg kegg NA NA no no up no no no Cardiac muscle contraction Peroxisome -0.591304348 -0.765810277 -0.485714286 kegg kegg NA NA no no up no no no Cardiac muscle contraction Phagosome -0.513913043 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Phosphatidylinositol signaling system 0.542608696 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Phospholipase D signaling pathway 0 -0.499011858 0 kegg kegg NA NA no no up no up up Cardiac muscle contraction PPAR signaling pathway 0 -0.600790514 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Propanoate metabolism 0 0.418972332 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Proteasome 0 0.446640316 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Protein export 0.449565217 0.721343874 0.472844273 kegg kegg NA NA no no up no no no Cardiac muscle contraction Protein processing in endoplasmic reticulum 0 0.581027668 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Pyrimidine metabolism -0.737391304 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Pyruvate metabolism 0 0.533596838 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Rap1 signaling pathway 0 0.472332016 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Ras signaling pathway 0 0.511857708 0.402831403 yes kegg kegg NA NA no no up no up up Cardiac muscle contraction Retinol metabolism -0.460869565 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Ribosome 0.636521739 0.843873518 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction RNA degradation 0.609565217 0.684782609 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction RNA polymerase 0 0.558300395 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction RNA transport 0 0.545454545 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction SNARE interactions in vesicular transport 0 -0.656126482 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Sphingolipid signaling pathway 0.453043478 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Starch and sucrose metabolism -0.459130435 -0.788537549 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Sulfur metabolism -0.453043478 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Tryptophan metabolism -0.57826087 0 0 kegg kegg NA NA no no up no up no Cardiac muscle contraction Ubiquinone and other terpenoid-quinone biosynthesis -0.408695652 0 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction Ubiquitin mediated proteolysis 0.460869565 0.773715415 0 kegg kegg NA NA no no up no no no Cardiac muscle contraction "Valine, leucine and isoleucine degradation" -0.508695652 0 0 kegg kegg NA NA no no up no no no CDCA+blood 12-ketoDCA+blood 0.477529792 0 0 serum_bileacids serum_bileacids 0.506 0.517 no no no no no no CDCA+blood 14:0-LPC+blood 0.551879699 0 0 serum_bileacids serum_phospholipids 0.506 0.00689 no no no up up no CDCA+blood 16:0/16:1-PI+blood 0.515789474 0 0 serum_bileacids serum_phospholipids 0.506 0.262 no no no no no no CDCA+blood 16:0/18:1-PC+blood -0.476691729 0 0 serum_bileacids serum_phospholipids 0.506 6.15E-07 no no no up up up CDCA+blood 16:0/20:5-PC+blood 0 0 0.433846154 serum_bileacids serum_phospholipids 0.506 0.628 no no no no no no CDCA+blood 16:0/20:5-PG+blood -0.578947368 0 0 serum_bileacids serum_phospholipids 0.506 0.00656 no no no no up no CDCA+blood 16:1-LPC+blood 0 -0.509803922 0 serum_bileacids serum_phospholipids 0.506 0.0241 no no no no up no CDCA+blood 16:1/16:0-PC+blood -0.533834586 0 0 serum_bileacids serum_phospholipids 0.506 0.0215 no no no no up up CDCA+blood 16:1/16:1-PC+blood -0.685714286 0 0 serum_bileacids serum_phospholipids 0.506 0.0177 no no no no no up CDCA+blood 16:1/18:1-PG+blood -0.714285714 0 0 serum_bileacids serum_phospholipids 0.506 3.21E-05 no no no no up up CDCA+blood 16:1/18:2-PG+blood -0.673684211 0 0 serum_bileacids serum_phospholipids 0.506 1.40E-08 no no no no up up CDCA+blood 18:0/16:0-PC+blood -0.508270677 0 0 serum_bileacids serum_phospholipids 0.506 9.64E-07 no no no up up up CDCA+blood 18:0/18:0-PS+blood -0.470676692 0 0 serum_bileacids serum_phospholipids 0.506 0.00617 no no no no up no CDCA+blood 18:0/18:2-PC+blood -0.454135338 0 0 serum_bileacids serum_phospholipids 0.506 1.74E-06 no no no no up up CDCA+blood 18:0/20:3-PI+blood -0.666165414 0 0 serum_bileacids serum_phospholipids 0.506 0.377 no no no no no no CDCA+blood 18:0/20:4-PI+blood -0.721804511 0 0 serum_bileacids serum_phospholipids 0.506 0.167 no no no no no no CDCA+blood 18:0/20:5-PC+blood 0 0 -0.411965812 serum_bileacids serum_phospholipids 0.506 0.17 no no no no no no CDCA+blood 18:0/22:6-PA+blood -0.609022556 0 0 serum_bileacids serum_phospholipids 0.506 0.22 no no no no no no CDCA+blood 18:1/18:0-PS+blood -0.727819549 0 0 serum_bileacids serum_phospholipids 0.506 0.193 no no no no no no CDCA+blood 18:1/18:1-PC+blood 0 0 -0.406495726 serum_bileacids serum_phospholipids 0.506 1.34E-05 no no no no up up CDCA+blood 18:1/18:1-PG+blood -0.62556391 0 0 serum_bileacids serum_phospholipids 0.506 0.00352 no no no no up up CDCA+blood 18:1/18:2-PG+blood -0.658646617 0 0 serum_bileacids serum_phospholipids 0.506 5.58E-07 no no no no up up CDCA+blood 18:1/20:3-PC+blood 0 0 -0.496752137 serum_bileacids serum_phospholipids 0.506 0.00872 no no no no up up CDCA+blood 18:1/20:4-PC+blood 0 0 -0.401025641 serum_bileacids serum_phospholipids 0.506 0.582 no no no no no no CDCA+blood 18:1+blood 0 0 -0.522735043 yes serum_bileacids serum_fattyacid 0.506 0.00202 no no no up no dn CDCA+blood 18:3-LPC+blood 0.65112782 0 0.406495726 serum_bileacids serum_phospholipids 0.506 0.147 no no no no no no CDCA+blood 18:3n3+blood -0.469172932 0 0 serum_bileacids serum_fattyacid 0.506 0.291 no no no no no no CDCA+blood 20:0/20:5-PC+blood -0.754887218 0 -0.498119658 serum_bileacids serum_phospholipids 0.506 0.882 no no no no no no CDCA+blood 20:1/20:4-PE+blood -0.559398496 0 0 serum_bileacids serum_phospholipids 0.506 0.0042 no no no up up no CDCA+blood 20:2/18:3-PE+blood 0 0 -0.442051282 serum_bileacids serum_phospholipids 0.506 0.0391 no no no up up no CDCA+blood 20:2+blood 0 0 -0.550769231 serum_bileacids serum_fattyacid 0.506 0.478 no no no no no no CDCA+blood 20:3/18:0-PC+blood -0.484210526 0 0 serum_bileacids serum_phospholipids 0.506 0.296 no no no no no no CDCA+blood 20:3/18:0-PI+blood -0.655639098 0 0 serum_bileacids serum_phospholipids 0.506 0.289 no no no no no no CDCA+blood 20:4-LPA+blood 0 -0.536764706 -0.424957265 serum_bileacids serum_phospholipids 0.506 0.398 no no no no no no CDCA+blood 20:4/18:0-PE+blood -0.476691729 0 0 serum_bileacids serum_phospholipids 0.506 0.000755 no no no up up no CDCA+blood 20:5-LPC+blood 0 0 0.422905983 serum_bileacids serum_phospholipids 0.506 0.558 no no no no no no CDCA+blood 20:5/18:0-PC+blood -0.446616541 0 0 serum_bileacids serum_phospholipids 0.506 3.97E-06 no no no no up up CDCA+blood 20:5n3+blood 0 0 0.512478632 serum_bileacids serum_fattyacid 0.506 0.988 no no no no no no CDCA+blood AA+blood -0.461654135 0 0 serum_bileacids serum_ARA 0.506 0.212 no no no no no no CDCA+blood Acute myeloid leukemia 0 -0.688235294 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Adherens junction 0 0.55 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Adrenergic signaling in cardiomyocytes 0 0.635294118 0 serum_bileacids kegg 0.506 NA no no no no no up CDCA+blood AGE-RAGE signaling pathway in diabetic complications 0 -0.852941176 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Aldosterone synthesis and secretion 0 0.617647059 0.462307692 serum_bileacids kegg 0.506 NA no no no no up up CDCA+blood Alzheimer disease 0 0.861764706 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Amoebiasis 0 -0.711764706 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Amphetamine addiction 0 0.761764706 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Amyotrophic lateral sclerosis 0 0.911764706 0.416923077 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Apelin signaling pathway 0 0.785294118 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Apoptosis 0 -0.679411765 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Arginine and proline metabolism 0 -0.832352941 0 serum_bileacids kegg 0.506 NA no no no no up no CDCA+blood Arrhythmogenic right ventricular cardiomyopathy 0 0.567647059 0 serum_bileacids kegg 0.506 NA no no no no up up CDCA+blood Autophagy - animal 0 -0.705882353 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood B cell receptor signaling pathway 0 -0.708823529 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Biosynthesis of amino acids 0 -0.7 -0.401538462 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Biosynthesis of cofactors 0.485964912 0.511764706 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Bladder cancer 0 -0.867647059 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Breast cancer 0 -0.661764706 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood C-type lectin receptor signaling pathway 0 -0.697058824 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood CA+blood 0.811583359 0.638871978 0.83053662 serum_bileacids serum_bileacids 0.506 0.606 no no no no no no CDCA+blood CA+stool 0 0 0.490225564 serum_bileacids stool_bileacids 0.506 0.827 no no no no no no CDCA+blood capric acid C6+blood 0 0 -0.427008547 serum_bileacids serum_scfa 0.506 0.433 no no no no no no CDCA+blood Carbon metabolism 0 0 -0.512307692 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Cardiac muscle contraction 0 0.808823529 0.406923077 serum_bileacids kegg 0.506 NA no no no no no up CDCA+blood Cell cycle 0 0.702941176 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Cellular senescence 0 -0.570588235 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood cGMP-PKG signaling pathway 0 -0.758823529 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Chagas disease 0 -0.664705882 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Chemokine signaling pathway 0 -0.658823529 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Choline metabolism in cancer 0 -0.541176471 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Clostridium 0 0 0.408967364 serum_bileacids Genus 0.506 0.925 no no no no no no CDCA+blood Coprococcus 0 0 -0.532307692 butyrate-producing serum_bileacids Genus 0.506 0.612 no no no no no no CDCA+blood Coronavirus disease - COVID-19 0 0.802941176 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Cortisol synthesis and secretion 0 0 0.466153846 serum_bileacids kegg 0.506 NA no no no no no up CDCA+blood Cytosolic DNA-sensing pathway 0.468421053 0 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Diabetic cardiomyopathy 0 0.844117647 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Dilated cardiomyopathy 0 0.570588235 0 serum_bileacids kegg 0.506 NA no no no no up up CDCA+blood Dopaminergic synapse 0 0.517647059 0.404615385 serum_bileacids kegg 0.506 NA no no no no up no CDCA+blood EGFR tyrosine kinase inhibitor resistance 0 0.752941176 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Endocytosis 0 -0.514705882 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Epithelial cell signaling in Helicobacter pylori infection 0 -0.782352941 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood ErbB signaling pathway 0 -0.5 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Estrogen signaling pathway 0 0.644117647 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Fc epsilon RI signaling pathway 0 -0.832352941 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Fc gamma R-mediated phagocytosis -0.540350877 -0.697058824 -0.499230769 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Focal adhesion 0 0.529411765 0 serum_bileacids kegg 0.506 NA no no no no up up CDCA+blood FoxO signaling pathway 0 -0.629411765 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood GABAergic synapse 0 -0.802941176 0 serum_bileacids kegg 0.506 NA no no no no up up CDCA+blood Gastric acid secretion 0 0.591176471 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Glucagon signaling pathway 0 0.764705882 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Glutamatergic synapse 0 -0.691176471 0 serum_bileacids kegg 0.506 NA no no no no up up CDCA+blood "Glycine, serine and threonine metabolism" 0.5 0 0 serum_bileacids kegg 0.506 NA no no no no up no CDCA+blood Glycolysis / Gluconeogenesis 0 0.623529412 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood "Growth hormone synthesis, secretion and action" 0 -0.517647059 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood HCA+stool 0 0 0.497744361 serum_bileacids stool_bileacids 0.506 0.155 no no no no no no CDCA+blood Hepatitis B 0 -0.785294118 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood HIF-1 signaling pathway 0 0.752941176 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Hippo signaling pathway 0 0.688235294 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Human papillomavirus infection 0 -0.529411765 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Huntington disease 0 0.847058824 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood IL-17 signaling pathway 0 -0.732352941 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Inflammatory mediator regulation of TRP channels 0 0.726470588 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Insulin resistance 0 -0.585294118 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Insulin secretion 0 0 0.430769231 yes serum_bileacids kegg 0.506 NA no no no no up up CDCA+blood Insulin signaling pathway 0 0.805882353 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood iso-LCA+stool 0 0 -0.458646617 serum_bileacids stool_bileacids 0.506 0.72 no no no no no no CDCA+blood JAK-STAT signaling pathway 0 -0.658823529 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Lipid and atherosclerosis 0 -0.755882353 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Long-term potentiation 0 0.755882353 0 serum_bileacids kegg 0.506 NA no no no no no up CDCA+blood Lysosome 0 -0.570588235 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Melanogenesis 0 0.667647059 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood MicroRNAs in cancer 0 -0.564705882 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Mitophagy - animal 0.529824561 0.611764706 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Morphine addiction 0 0 0.481538462 serum_bileacids kegg 0.506 NA no no no no up up CDCA+blood mRNA surveillance pathway 0 0.738235294 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood mTOR signaling pathway 0 0.738235294 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Natural killer cell mediated cytotoxicity 0 -0.511764706 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Neuroactive ligand-receptor interaction 0 -0.520588235 0 serum_bileacids kegg 0.506 NA no no no up up up CDCA+blood Neutrophil extracellular trap formation 0 -0.667647059 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood NF-kappa B signaling pathway 0 -0.708823529 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Nicotinate and nicotinamide metabolism 0 -0.9 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood NOD-like receptor signaling pathway 0 -0.779411765 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Non-alcoholic fatty liver disease 0 0.738235294 0.486923077 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Non-small cell lung cancer 0 -0.505882353 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Olfactory transduction -0.515789474 -0.688235294 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Oocyte meiosis 0 0.761764706 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Osteoclast differentiation 0 -0.767647059 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Oxidative phosphorylation 0 0.847058824 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Parkinson disease 0 0.785294118 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Pathways of neurodegeneration - multiple diseases 0 0.791176471 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.576470588 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Peroxisome 0 -0.735294118 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Pertussis 0 -0.673529412 0 serum_bileacids kegg 0.506 NA no no no no no dn CDCA+blood Phagosome 0 -0.55 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Phospholipase D signaling pathway 0 -0.811764706 0 serum_bileacids kegg 0.506 NA no no no no up up CDCA+blood PPAR signaling pathway 0 -0.738235294 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Prion disease 0 0.9 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Prolactin signaling pathway 0 -0.782352941 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Prostate cancer 0 -0.511764706 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Proteasome 0 0.691176471 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Protein processing in endoplasmic reticulum 0 0.864705882 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Proteoglycans in cancer 0.61754386 0.782352941 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Purine metabolism 0 0.573529412 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Ras signaling pathway 0 0.685294118 0 yes serum_bileacids kegg 0.506 NA no no no no up up CDCA+blood Regulation of actin cytoskeleton 0 0.594117647 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Relaxin signaling pathway 0.484210526 -0.526470588 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Renin secretion 0 0.723529412 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Retrograde endocannabinoid signaling 0 0.826470588 0.403846154 serum_bileacids kegg 0.506 NA no no no no no up CDCA+blood Rheumatoid arthritis 0 -0.647058824 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Ribosome 0 0.802941176 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Ribosome biogenesis in eukaryotes 0 0.679411765 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood RIG-I-like receptor signaling pathway 0 -0.688235294 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood RNA degradation 0 0.797058824 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood RNA transport 0 0.714705882 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Serotonergic synapse 0 -0.55 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Shigellosis 0.489473684 0.5 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Small cell lung cancer 0.470175439 0 0 serum_bileacids kegg 0.506 NA no no no no no up CDCA+blood Spinocerebellar ataxia 0 0.676470588 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Staphylococcus aureus infection 0 -0.564705882 -0.494615385 serum_bileacids kegg 0.506 NA no no no up no no CDCA+blood Systemic lupus erythematosus -0.461403509 -0.655882353 -0.482307692 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Thermogenesis 0 0.855882353 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Thyroid hormone signaling pathway 0 0.511764706 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood TNF signaling pathway 0 -0.617647059 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Toll-like receptor signaling pathway 0 -0.794117647 0 yes serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Transcriptional misregulation in cancer 0 -0.673529412 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Tuberculosis -0.505263158 -0.629411765 -0.463846154 serum_bileacids kegg 0.506 NA no no no no no dn CDCA+blood Ubiquitin mediated proteolysis 0.526315789 0.755882353 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood UDCA+stool 0 0 0.467669173 serum_bileacids stool_bileacids 0.506 0.266 no no no no no no CDCA+blood Vascular smooth muscle contraction 0 0.655882353 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Viral carcinogenesis 0 -0.594117647 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Wnt signaling pathway 0 0.823529412 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+blood Yersinia infection 0 -0.614705882 0 serum_bileacids kegg 0.506 NA no no no no no no CDCA+stool 12-ketoDCA+stool -0.475748194 0 0 stool_bileacids stool_bileacids 0.663 0.505 no no no no no no CDCA+stool 4-hydroxybenzoic acid+stool 0 0 0.450592885 stool_bileacids stool_cometabolism 0.663 0.0536 no no no no dn no CDCA+stool Adipocytokine signaling pathway 0 0 -0.55053642 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Adrenergic signaling in cardiomyocytes 0 -0.618181818 0.422924901 stool_bileacids kegg 0.663 NA no no no no no up CDCA+stool Aldosterone synthesis and secretion 0 0 0.426312818 stool_bileacids kegg 0.663 NA no no no no up up CDCA+stool Allograft rejection 0 0.790909091 0.569734613 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Alzheimer disease -0.527347781 0 0.696216827 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Amphetamine addiction -0.609907121 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool AMPK signaling pathway 0 -0.609090909 -0.553924337 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Amyotrophic lateral sclerosis -0.578947368 0 0.700734049 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Apoptosis 0.609907121 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Asthma 0 0.609090909 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Autoimmune thyroid disease 0 0.790909091 0.569734613 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Bacteroides 0.599587203 0 0 LPS-producing stool_bileacids Genus 0.663 0.000267 no no no dn dn up CDCA+stool Biosynthesis of amino acids 0.647058824 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Blautia 0 0.664335664 0 acetate-producing stool_bileacids Genus 0.663 1.36E-05 no no no up dn dn CDCA+stool CA+stool 0.867905057 0.874125874 0.914031621 stool_bileacids stool_bileacids 0.663 0.827 no no no no no no CDCA+stool Carbon metabolism 0 0.627272727 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Cardiac muscle contraction -0.471620227 0 0.682665161 stool_bileacids kegg 0.663 NA no no no no no up CDCA+stool Cell adhesion molecules 0.477812178 0.7 0.491812535 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Cellular senescence 0.628482972 0.681818182 0.560700169 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Chemical carcinogenesis - receptor activation 0 -0.663636364 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Clostridium 0 0.58041958 0 stool_bileacids Genus 0.663 0.925 no no no no no no CDCA+stool Cocaine addiction 0 -0.609090909 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Coprococcus 0 0 -0.462450593 butyrate-producing stool_bileacids Genus 0.663 0.612 no no no no no no CDCA+stool Coronavirus disease - COVID-19 -0.541795666 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Cortisol synthesis and secretion 0 -0.718181818 0 stool_bileacids kegg 0.663 NA no no no no no up CDCA+stool Cushing syndrome -0.504643963 0 0 stool_bileacids kegg 0.663 NA no no no no no up CDCA+stool Diabetic cardiomyopathy -0.488132095 0 0.656691135 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Dorea 0.500515996 0.685314685 0 stool_bileacids Genus 0.663 0.00362 no no no up no dn CDCA+stool Endocrine resistance -0.543859649 -0.672727273 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Endocytosis 0.636738906 0.618181818 0.535855449 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Epithelial cell signaling in Helicobacter pylori infection 0.713106295 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Epstein-Barr virus infection 0 0 0.424054207 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Fc gamma R-mediated phagocytosis 0.533539732 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool FoxO signaling pathway 0 0 -0.516657256 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool GABAergic synapse 0.543859649 0 0 stool_bileacids kegg 0.663 NA no no no no up up CDCA+stool Glutamatergic synapse 0 -0.663636364 0 stool_bileacids kegg 0.663 NA no no no no up up CDCA+stool GnRH signaling pathway 0 -0.618181818 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Graft-versus-host disease 0 0.790909091 0.55053642 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool "Growth hormone synthesis, secretion and action" 0 -0.672727273 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Herpes simplex virus 1 infection 0 0.654545455 0.514398645 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Hippo signaling pathway 0 0.618181818 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Human cytomegalovirus infection 0 0 0.446640316 stool_bileacids kegg 0.663 NA no no no no no dn CDCA+stool Human immunodeficiency virus 1 infection 0 0 0.444381705 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Human papillomavirus infection 0.620227038 0.618181818 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Human T-cell leukemia virus 1 infection 0 0 0.488424619 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Huntington disease -0.583075335 0 0.658949746 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool IL-17 signaling pathway 0.510835913 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Insulin secretion 0 -0.654545455 0 yes stool_bileacids kegg 0.663 NA no no no no up up CDCA+stool JAK-STAT signaling pathway 0 0 -0.501976285 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Lipid and atherosclerosis 0.576883385 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Long-term potentiation 0 0 0.495200452 stool_bileacids kegg 0.663 NA no no no no no up CDCA+stool Longevity regulating pathway 0 -0.7 -0.541501976 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Lysosome 0.498452012 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Melanogenesis -0.494324045 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Mitophagy - animal 0 0 -0.434217956 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool mRNA surveillance pathway -0.492260062 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Natural killer cell mediated cytotoxicity 0.576883385 0.681818182 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Neutrophil extracellular trap formation 0.620227038 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool NOD-like receptor signaling pathway 0.500515996 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Non-alcoholic fatty liver disease -0.475748194 0 0.567476002 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Oscillospira 0 0 -0.477272727 LPS-producing stool_bileacids Genus 0.663 0.62 no no no no no no CDCA+stool Osteoclast differentiation 0.568627451 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Oxidative phosphorylation -0.525283798 0 0.661208357 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Parkinson disease -0.488132095 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Pathogenic Escherichia coli infection 0.492260062 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Pathways in cancer 0 0 -0.542631282 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Pathways of neurodegeneration - multiple diseases -0.488132095 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Peroxisome 0.506707946 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Pertussis 0.694530444 0 0 stool_bileacids kegg 0.663 NA no no no no no dn CDCA+stool Phagosome 0.523219814 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Porphyrin and chlorophyll metabolism 0 0 -0.4432524 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Prion disease -0.498452012 0 0.682665161 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Proteasome 0 0.790909091 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Purine metabolism 0 0 -0.508752117 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Regulation of actin cytoskeleton 0 0 0.518915867 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Regulation of lipolysis in adipocytes 0 -0.663636364 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Retrograde endocannabinoid signaling 0 0 0.743647657 stool_bileacids kegg 0.663 NA no no no no no up CDCA+stool Ribosome -0.564499484 0 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Roseburia 0 0 0.420948617 butyrate-producing stool_bileacids Genus 0.663 0.495 no no no no no no CDCA+stool Salmonella infection 0.50877193 0.627272727 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Serotonergic synapse 0 -0.8 0 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Thermogenesis -0.614035088 0 0.608130999 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Type I diabetes mellitus 0 0.790909091 0.571993224 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Viral carcinogenesis 0.570691434 0 0.4432524 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool Viral myocarditis 0 0.818181818 0.599096556 stool_bileacids kegg 0.663 NA no no no no no no CDCA+stool ¦Ø-MCA+stool 0 0.592647768 0 stool_bileacids stool_bileacids 0.663 0.919 no no no no no no Cell adhesion molecules 2-Oxocarboxylic acid metabolism 0.489565217 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Adrenergic signaling in cardiomyocytes 0 -0.550395257 0 kegg kegg NA NA no no no no no up Cell adhesion molecules alpha-Linolenic acid metabolism 0.427826087 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Amino sugar and nucleotide sugar metabolism 0 0 -0.425225225 kegg kegg NA NA no no no no no no Cell adhesion molecules AMPK signaling pathway 0 -0.685770751 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Antifolate resistance 0 0 -0.60978121 kegg kegg NA NA no no no no no no Cell adhesion molecules Apelin signaling pathway -0.465217391 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Apoptosis 0.492173913 0.692687747 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Apoptosis - multiple species 0 0 -0.557528958 kegg kegg NA NA no no no no no no Cell adhesion molecules Autophagy - other -0.564347826 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Bacteroides 0.432173913 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Cell adhesion molecules Basal transcription factors -0.617391304 -0.602766798 -0.625997426 kegg kegg NA NA no no no no no no Cell adhesion molecules Base excision repair 0 -0.471343874 -0.491891892 kegg kegg NA NA no no no no no no Cell adhesion molecules beta-Alanine metabolism 0.449565217 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Biosynthesis of amino acids 0.705217391 0.695652174 0.486743887 kegg kegg NA NA no no no no no no Cell adhesion molecules Biosynthesis of cofactors 0 -0.809288538 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Butyricicoccus 0 0 0.509406759 butyrate-producing kegg Genus NA 0.852 no no no no no no Cell adhesion molecules cAMP signaling pathway -0.500869565 0 0 yes kegg kegg NA NA no no no no up up Cell adhesion molecules Carbon metabolism 0.611304348 0.576086957 0.415958816 kegg kegg NA NA no no no no no no Cell adhesion molecules Cardiac muscle contraction -0.487826087 0 0 kegg kegg NA NA no no no no no up Cell adhesion molecules Cell cycle -0.548695652 -0.615612648 -0.400772201 kegg kegg NA NA no no no no no no Cell adhesion molecules Cellular senescence 0.859130435 0.913043478 0.824195624 kegg kegg NA NA no no no no no no Cell adhesion molecules cGMP-PKG signaling pathway 0 0.58201581 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Chemokine signaling pathway 0 0.472332016 0.490862291 kegg kegg NA NA no no no no no no Cell adhesion molecules DNA replication 0 0 -0.445817246 kegg kegg NA NA no no no no no no Cell adhesion molecules Endocrine resistance 0 -0.662055336 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Endocytosis 0.894782609 0.967391304 0.881595882 kegg kegg NA NA no no no no no no Cell adhesion molecules Ether lipid metabolism -0.615652174 -0.751976285 -0.501930502 kegg kegg NA NA no no no no no no Cell adhesion molecules Fanconi anemia pathway 0 -0.500988142 -0.524839125 kegg kegg NA NA no no no no no no Cell adhesion molecules Focal adhesion 0.446956522 0 0 kegg kegg NA NA no no no no up up Cell adhesion molecules Folate biosynthesis -0.424347826 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules FoxO signaling pathway 0 0 -0.428828829 kegg kegg NA NA no no no no no no Cell adhesion molecules Galactose metabolism 0 0.423913043 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Glutathione metabolism 0 -0.585968379 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Glycerophospholipid metabolism -0.551304348 -0.435770751 -0.477220077 kegg kegg NA NA no no no no no up Cell adhesion molecules "Glycine, serine and threonine metabolism" 0 -0.750988142 0 kegg kegg NA NA no no no no up no Cell adhesion molecules Glycolysis / Gluconeogenesis 0.470434783 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.47826087 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Glycosaminoglycan degradation 0 0.609683794 0 kegg kegg NA NA no no no no no up Cell adhesion molecules Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.714426877 -0.417503218 kegg kegg NA NA no no no no no no Cell adhesion molecules Hedgehog signaling pathway -0.446956522 -0.42687747 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Homologous recombination 0 -0.43083004 -0.580694981 kegg kegg NA NA no no no no no no Cell adhesion molecules Inositol phosphate metabolism 0 0 -0.461261261 kegg kegg NA NA no no no no no no Cell adhesion molecules Longevity regulating pathway 0 -0.507905138 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Lysine degradation 0 0 -0.423680824 kegg kegg NA NA no no no no no no Cell adhesion molecules Lysosome 0 0.733201581 0 kegg kegg NA NA no no no no no no Cell adhesion molecules MAPK signaling pathway -0.45826087 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Mismatch repair 0 -0.469367589 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Mitophagy - animal 0 -0.571146245 0 kegg kegg NA NA no no no no no no Cell adhesion molecules mRNA surveillance pathway -0.703478261 -0.494071146 -0.42033462 kegg kegg NA NA no no no no no no Cell adhesion molecules Neuroactive ligand-receptor interaction 0 0.682806324 0 kegg kegg NA NA no no no up up up Cell adhesion molecules Nicotinate and nicotinamide metabolism 0 0.425889328 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Non-homologous end-joining 0.41826087 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Nucleotide excision repair 0 -0.550395257 -0.570913771 kegg kegg NA NA no no no no no no Cell adhesion molecules One carbon pool by folate 0 -0.54743083 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Oocyte meiosis -0.543478261 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Osteoclast differentiation 0 0.654150198 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Other types of O-glycan biosynthesis -0.596521739 -0.54743083 -0.551093951 kegg kegg NA NA no no no no no no Cell adhesion molecules Oxidative phosphorylation -0.53826087 -0.418972332 0 kegg kegg NA NA no no no no no no Cell adhesion molecules p53 signaling pathway -0.559130435 -0.4743083 -0.645817246 kegg kegg NA NA no no no no no no Cell adhesion molecules Pantothenate and CoA biosynthesis 0 0.416996047 0 kegg kegg NA NA no no no no no dn Cell adhesion molecules Pentose phosphate pathway 0.568695652 0.721343874 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Phagosome 0.925217391 0.943675889 0.899099099 kegg kegg NA NA no no no no no no Cell adhesion molecules Phosphatidylinositol signaling system -0.475652174 0 -0.480823681 kegg kegg NA NA no no no no no no Cell adhesion molecules PI3K-Akt signaling pathway -0.414782609 0 0 yes kegg kegg NA NA no no no no up up Cell adhesion molecules Platinum drug resistance 0 0 -0.594079794 kegg kegg NA NA no no no no no no Cell adhesion molecules Porphyrin and chlorophyll metabolism 0 -0.723320158 0 kegg kegg NA NA no no no no no no Cell adhesion molecules PPAR signaling pathway 0 0.557312253 0.472844273 kegg kegg NA NA no no no no no no Cell adhesion molecules Protein export -0.62173913 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Protein processing in endoplasmic reticulum 0 -0.502964427 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Purine metabolism 0 -0.755928854 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Pyrimidine metabolism 0 -0.450592885 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Ribosome -0.526956522 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Ribosome biogenesis in eukaryotes -0.447826087 -0.533596838 -0.437065637 kegg kegg NA NA no no no no no no Cell adhesion molecules RNA degradation -0.62173913 -0.42687747 0 kegg kegg NA NA no no no no no no Cell adhesion molecules RNA polymerase -0.52 -0.595849802 -0.466666667 kegg kegg NA NA no no no no no no Cell adhesion molecules Ruminococcus 0 0 0.426254826 acetate-producing kegg Genus NA 0.335 no no no no no no Cell adhesion molecules Selenocompound metabolism -0.567826087 -0.466403162 -0.553153153 kegg kegg NA NA no no no no no no Cell adhesion molecules Sphingolipid signaling pathway 0 0.698616601 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Steroid biosynthesis -0.64173913 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Synthesis and degradation of ketone bodies 0 -0.51284585 -0.425482625 kegg kegg NA NA no no no no no no Cell adhesion molecules Taurine and hypotaurine metabolism -0.504347826 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Terpenoid backbone biosynthesis -0.663478261 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules TGF-beta signaling pathway -0.52173913 0 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Thiamine metabolism 0 -0.482213439 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Ubiquinone and other terpenoid-quinone biosynthesis 0 0 -0.463063063 kegg kegg NA NA no no no no no no Cell adhesion molecules Ubiquitin mediated proteolysis 0 -0.640316206 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Vascular smooth muscle contraction -0.413043478 -0.423913043 0 kegg kegg NA NA no no no no no no Cell adhesion molecules Wnt signaling pathway -0.420869565 -0.427865613 0 kegg kegg NA NA no no no no no no Cell cycle 2-Oxocarboxylic acid metabolism 0 0.646245059 0 kegg kegg NA NA no no no no no no Cell cycle "Alanine, aspartate and glutamate metabolism" 0 -0.563241107 -0.551608752 kegg kegg NA NA no no no no no no Cell cycle Aminoacyl-tRNA biosynthesis 0 0.723320158 0.604633205 kegg kegg NA NA no no no no no no Cell cycle Antifolate resistance 0 0.716403162 0.433719434 kegg kegg NA NA no no no no no no Cell cycle Arachidonic acid metabolism 0 0 -0.525353925 kegg kegg NA NA no no no no no no Cell cycle Arginine and proline metabolism 0 -0.664031621 -0.61029601 kegg kegg NA NA no no no no up no Cell cycle Arginine biosynthesis 0 -0.614624506 -0.683912484 kegg kegg NA NA no no no no no no Cell cycle Basal transcription factors 0.729565217 0.837944664 0.803346203 kegg kegg NA NA no no no no no no Cell cycle Base excision repair 0.73826087 0.85770751 0.714285714 kegg kegg NA NA no no no no no no Cell cycle Biosynthesis of amino acids -0.437391304 -0.781620553 -0.808751609 kegg kegg NA NA no no no no no no Cell cycle Biosynthesis of cofactors 0 0.70256917 0 kegg kegg NA NA no no no no no no Cell cycle Biosynthesis of unsaturated fatty acids 0.423478261 0 0 kegg kegg NA NA no no no no no no Cell cycle Butanoate metabolism 0 0.641304348 0 kegg kegg NA NA no no no no no no Cell cycle Calcium signaling pathway 0 0 0.436036036 kegg kegg NA NA no no no no up up Cell cycle cAMP signaling pathway 0 -0.56027668 0 yes kegg kegg NA NA no no no no up up Cell cycle Carbon metabolism 0 0 -0.625482625 kegg kegg NA NA no no no no no no Cell cycle cGMP-PKG signaling pathway 0 -0.884387352 0 kegg kegg NA NA no no no no no no Cell cycle Chemokine signaling pathway -0.435652174 -0.719367589 -0.563963964 kegg kegg NA NA no no no no no no Cell cycle Citrate cycle (TCA cycle) 0.422608696 0.604743083 0.423680824 kegg kegg NA NA no no no no no no Cell cycle Cysteine and methionine metabolism 0.683478261 0.602766798 0.573487773 kegg kegg NA NA no no no no no no Cell cycle DNA replication 0.783478261 0.842885375 0.650965251 kegg kegg NA NA no no no no no no Cell cycle Drug metabolism - cytochrome P450 0 0.609683794 0 kegg kegg NA NA no no no no no no Cell cycle Drug metabolism - other enzymes 0 0.419960474 0 kegg kegg NA NA no no no no no no Cell cycle EGFR tyrosine kinase inhibitor resistance 0.429565217 0.435770751 0 kegg kegg NA NA no no no no no no Cell cycle ErbB signaling pathway 0 0 0.471299871 kegg kegg NA NA no no no no no no Cell cycle Ether lipid metabolism 0 0.609683794 0.566795367 kegg kegg NA NA no no no no no no Cell cycle Fanconi anemia pathway 0.851304348 0.817193676 0.796911197 kegg kegg NA NA no no no no no no Cell cycle Fatty acid biosynthesis 0 -0.597826087 -0.403861004 kegg kegg NA NA no no no no no no Cell cycle Folate biosynthesis 0.493043478 0.502964427 0 kegg kegg NA NA no no no no no no Cell cycle FoxO signaling pathway 0 0 0.434234234 kegg kegg NA NA no no no no no no Cell cycle Glutathione metabolism 0 0.466403162 0 kegg kegg NA NA no no no no no no Cell cycle Glycerolipid metabolism 0 0 0.485456885 kegg kegg NA NA no no no no no up Cell cycle Glycerophospholipid metabolism 0 0 0.66048906 kegg kegg NA NA no no no no no up Cell cycle "Glycine, serine and threonine metabolism" 0 0.54743083 0 kegg kegg NA NA no no no no up no Cell cycle Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.616521739 0 0 kegg kegg NA NA no no no no no no Cell cycle Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.595849802 0 kegg kegg NA NA no no no no no no Cell cycle Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.542599743 kegg kegg NA NA no no no no no no Cell cycle Glycosaminoglycan degradation -0.591304348 -0.615612648 0 kegg kegg NA NA no no no no no up Cell cycle Glycosphingolipid biosynthesis - ganglio series 0 0.648221344 0 kegg kegg NA NA no no no no no no Cell cycle Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.633043478 0.565217391 0 kegg kegg NA NA no no no no no no Cell cycle Glyoxylate and dicarboxylate metabolism 0 -0.654150198 -0.710939511 kegg kegg NA NA no no no no no no Cell cycle HIF-1 signaling pathway 0.423478261 0 0 kegg kegg NA NA no no no no no no Cell cycle Homologous recombination 0.782608696 0.621541502 0.793050193 kegg kegg NA NA no no no no no no Cell cycle Inositol phosphate metabolism 0 0 0.597683398 kegg kegg NA NA no no no no no no Cell cycle Lysine degradation 0.437391304 0.674901186 0.763706564 kegg kegg NA NA no no no no no no Cell cycle Mannose type O-glycan biosynthesis 0 0.5256917 0.718918919 kegg kegg NA NA no no no no no no Cell cycle MAPK signaling pathway 0.504347826 0 0 kegg kegg NA NA no no no no no no Cell cycle Metabolism of xenobiotics by cytochrome P450 0 0.498023715 0 kegg kegg NA NA no no no no no no Cell cycle Mismatch repair 0.629565217 0.719367589 0.435263835 kegg kegg NA NA no no no no no no Cell cycle mRNA surveillance pathway 0.448695652 0.72826087 0.826254826 kegg kegg NA NA no no no no no no Cell cycle Mucin type O-glycan biosynthesis 0.585217391 0 0 kegg kegg NA NA no no no no no no Cell cycle N-Glycan biosynthesis 0.767826087 0.835968379 0.803861004 kegg kegg NA NA no no no no no no Cell cycle Neuroactive ligand-receptor interaction 0 -0.683794466 -0.696525097 kegg kegg NA NA no no no up up up Cell cycle NF-kappa B signaling pathway 0 -0.456521739 0 kegg kegg NA NA no no no no no no Cell cycle Nicotinate and nicotinamide metabolism 0 -0.721343874 -0.720978121 kegg kegg NA NA no no no no no no Cell cycle Nitrogen metabolism -0.566956522 -0.637351779 -0.624967825 kegg kegg NA NA no no no no no no Cell cycle Nucleotide excision repair 0.815652174 0.866600791 0.657915058 kegg kegg NA NA no no no no no no Cell cycle One carbon pool by folate 0.790434783 0.860671937 0.715830116 kegg kegg NA NA no no no no no no Cell cycle Other types of O-glycan biosynthesis 0.628695652 0.685770751 0.832947233 kegg kegg NA NA no no no no no no Cell cycle Pantothenate and CoA biosynthesis 0 -0.621541502 -0.561389961 kegg kegg NA NA no no no no no dn Cell cycle Paraprevotella 0 0.447554847 0 kegg Genus NA 0.118 no no no no no no Cell cycle Pentose and glucuronate interconversions 0.466086957 0.706521739 0.571428571 kegg kegg NA NA no no no no no no Cell cycle Pentose phosphate pathway -0.669565217 -0.839920949 -0.852767053 kegg kegg NA NA no no no no no no Cell cycle Phenylalanine metabolism 0 0.52173913 0 kegg kegg NA NA no no no no no no Cell cycle Phosphatidylinositol signaling system 0.55826087 0.72826087 0.832689833 kegg kegg NA NA no no no no no no Cell cycle Phospholipase D signaling pathway -0.495652174 -0.483201581 0 kegg kegg NA NA no no no no up up Cell cycle Platinum drug resistance 0.616521739 0.583003953 0.642728443 kegg kegg NA NA no no no no no no Cell cycle Porphyrin and chlorophyll metabolism 0 0.461462451 0 kegg kegg NA NA no no no no no no Cell cycle PPAR signaling pathway 0 -0.704545455 -0.661518662 kegg kegg NA NA no no no no no no Cell cycle Primary bile acid biosynthesis 0.553043478 0 0 kegg kegg NA NA no no no no no no Cell cycle Propanoate metabolism 0.540869565 0.518774704 0.441956242 kegg kegg NA NA no no no no no no Cell cycle Protein export 0.726086957 0.508893281 0.668983269 kegg kegg NA NA no no no no no no Cell cycle Purine metabolism 0 0.595849802 0 kegg kegg NA NA no no no no no no Cell cycle Pyrimidine metabolism 0 0.692687747 0 kegg kegg NA NA no no no no no no Cell cycle Pyruvate metabolism 0.597391304 0.612648221 0 kegg kegg NA NA no no no no no no Cell cycle Rap1 signaling pathway -0.532173913 0 0 kegg kegg NA NA no no no no no no Cell cycle Ras signaling pathway 0 0.575098814 0.722007722 yes kegg kegg NA NA no no no no up up Cell cycle Retinol metabolism 0 0.650197628 0 kegg kegg NA NA no no no no no no Cell cycle Ribosome biogenesis in eukaryotes 0.833043478 0.934782609 0.894980695 kegg kegg NA NA no no no no no no Cell cycle RNA degradation 0.428695652 0.733201581 0.85997426 kegg kegg NA NA no no no no no no Cell cycle RNA polymerase 0.699130435 0.911067194 0.664350064 kegg kegg NA NA no no no no no no Cell cycle RNA transport 0.52173913 0 0 kegg kegg NA NA no no no no no no Cell cycle Selenocompound metabolism 0.524347826 0.670948617 0.651480051 kegg kegg NA NA no no no no no no Cell cycle Sphingolipid metabolism -0.635652174 0 0 kegg kegg NA NA no no no no no no Cell cycle Sphingolipid signaling pathway 0 -0.555335968 0 kegg kegg NA NA no no no no no no Cell cycle Spliceosome 0.707826087 0.62944664 0.864350064 kegg kegg NA NA no no no no no no Cell cycle Starch and sucrose metabolism 0 -0.562252964 -0.423680824 kegg kegg NA NA no no no no no no Cell cycle Steroid biosynthesis 0.596521739 0.536561265 0.54028314 kegg kegg NA NA no no no no no no Cell cycle Steroid hormone biosynthesis 0 0.446640316 0 kegg kegg NA NA no no no no no no Cell cycle Sulfur metabolism 0 0 -0.586615187 kegg kegg NA NA no no no no no no Cell cycle Synthesis and degradation of ketone bodies 0.69826087 0.79743083 0.595109395 kegg kegg NA NA no no no no no no Cell cycle Terpenoid backbone biosynthesis 0.744347826 0.614624506 0.702445302 kegg kegg NA NA no no no no no no Cell cycle Thiamine metabolism 0 0.480237154 0 kegg kegg NA NA no no no no no no Cell cycle Tyrosine metabolism 0 0.600790514 0 kegg kegg NA NA no no no no no no Cell cycle Ubiquinone and other terpenoid-quinone biosynthesis 0.448695652 0.707509881 0.481338481 kegg kegg NA NA no no no no no no Cell cycle "Valine, leucine and isoleucine degradation" 0.459130435 0.665019763 0.438095238 kegg kegg NA NA no no no no no no Cell cycle Various types of N-glycan biosynthesis 0.662608696 0.783596838 0.724324324 kegg kegg NA NA no no no no no no Cell cycle Viral protein interaction with cytokine and cytokine receptor 0 -0.524703557 0 kegg kegg NA NA no no no no no no Cellular senescence Amino sugar and nucleotide sugar metabolism 0 0 -0.571943372 kegg kegg NA NA no no no no no no Cellular senescence Aminoacyl-tRNA biosynthesis 0 -0.416007905 0 kegg kegg NA NA no no no no no no Cellular senescence AMPK signaling pathway 0 -0.558300395 0 kegg kegg NA NA no no no no no no Cellular senescence Apoptosis 0 0.81027668 0 kegg kegg NA NA no no no no no no Cellular senescence Apoptosis - multiple species 0 0 -0.566023166 kegg kegg NA NA no no no no no no Cellular senescence Ascorbate and aldarate metabolism -0.547826087 0 0 kegg kegg NA NA no no no no no no Cellular senescence Basal transcription factors -0.566086957 -0.604743083 0 kegg kegg NA NA no no no no no no Cellular senescence Base excision repair 0 -0.5 -0.446589447 kegg kegg NA NA no no no no no no Cellular senescence Biosynthesis of amino acids 0.532173913 0.617588933 0 kegg kegg NA NA no no no no no no Cellular senescence Biosynthesis of cofactors 0 -0.855731225 0 kegg kegg NA NA no no no no no no Cellular senescence Butanoate metabolism 0 -0.52173913 0 kegg kegg NA NA no no no no no no Cellular senescence Cell cycle -0.573043478 -0.641304348 0 kegg kegg NA NA no no no no no no Cellular senescence cGMP-PKG signaling pathway 0 0.563241107 0 kegg kegg NA NA no no no no no no Cellular senescence Chemokine signaling pathway 0.435652174 0.556324111 0.486743887 kegg kegg NA NA no no no no no no Cellular senescence Citrate cycle (TCA cycle) 0 -0.506916996 0 kegg kegg NA NA no no no no no no Cellular senescence Cysteine and methionine metabolism 0 -0.535573123 0 kegg kegg NA NA no no no no no no Cellular senescence DNA replication -0.406956522 -0.572134387 0 kegg kegg NA NA no no no no no no Cellular senescence Drug metabolism - cytochrome P450 0 -0.51284585 0 kegg kegg NA NA no no no no no no Cellular senescence Endocrine resistance 0 -0.422924901 0 kegg kegg NA NA no no no no no no Cellular senescence Endocytosis 0.955652174 0.935770751 0.947232947 kegg kegg NA NA no no no no no no Cellular senescence Ether lipid metabolism -0.551304348 -0.726284585 0 kegg kegg NA NA no no no no no no Cellular senescence Fanconi anemia pathway -0.475652174 -0.552371542 0 kegg kegg NA NA no no no no no no Cellular senescence Fatty acid biosynthesis 0 0.416007905 0 kegg kegg NA NA no no no no no no Cellular senescence FoxO signaling pathway 0 0 -0.456628057 kegg kegg NA NA no no no no no no Cellular senescence Galactose metabolism 0 0.434782609 0 kegg kegg NA NA no no no no no no Cellular senescence Glutathione metabolism 0 -0.636363636 0 kegg kegg NA NA no no no no no no Cellular senescence Glycerophospholipid metabolism -0.530434783 0 0 kegg kegg NA NA no no no no no up Cellular senescence "Glycine, serine and threonine metabolism" 0 -0.720355731 0 kegg kegg NA NA no no no no up no Cellular senescence Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.460869565 0.507905138 0 kegg kegg NA NA no no no no no no Cellular senescence Glycosaminoglycan degradation 0 0.533596838 0 kegg kegg NA NA no no no no no up Cellular senescence Glycosphingolipid biosynthesis - ganglio series -0.442608696 0 0 kegg kegg NA NA no no no no no no Cellular senescence Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.67687747 0 kegg kegg NA NA no no no no no no Cellular senescence Glyoxylate and dicarboxylate metabolism 0 0.429841897 0 kegg kegg NA NA no no no no no no Cellular senescence Histidine metabolism 0 0 -0.416731017 kegg kegg NA NA no no no no no no Cellular senescence Homologous recombination 0 -0.427865613 -0.514285714 kegg kegg NA NA no no no no no no Cellular senescence Lysosome 0 0.638339921 0 kegg kegg NA NA no no no no no no Cellular senescence Metabolism of xenobiotics by cytochrome P450 0 -0.434782609 0 kegg kegg NA NA no no no no no no Cellular senescence Mismatch repair 0 -0.690711462 0 kegg kegg NA NA no no no no no no Cellular senescence Mitophagy - animal 0 -0.475296443 0 kegg kegg NA NA no no no no no no Cellular senescence mRNA surveillance pathway -0.522608696 -0.423913043 0 kegg kegg NA NA no no no no no no Cellular senescence mTOR signaling pathway 0 -0.423913043 0 kegg kegg NA NA no no no no no no Cellular senescence N-Glycan biosynthesis 0 -0.507905138 0 kegg kegg NA NA no no no no no no Cellular senescence Neuroactive ligand-receptor interaction 0 0.575098814 0 kegg kegg NA NA no no no up up up Cellular senescence NF-kappa B signaling pathway 0 0.477272727 0 kegg kegg NA NA no no no no no no Cellular senescence Nicotinate and nicotinamide metabolism 0 0.522727273 0 kegg kegg NA NA no no no no no no Cellular senescence Nitrogen metabolism 0.491304348 0 0 kegg kegg NA NA no no no no no no Cellular senescence Nucleotide excision repair -0.450434783 -0.703557312 -0.532046332 kegg kegg NA NA no no no no no no Cellular senescence One carbon pool by folate -0.516521739 -0.666007905 0 kegg kegg NA NA no no no no no no Cellular senescence Oocyte meiosis 0 -0.433794466 0 kegg kegg NA NA no no no no no no Cellular senescence Other types of O-glycan biosynthesis -0.52 0 0 kegg kegg NA NA no no no no no no Cellular senescence p53 signaling pathway -0.436521739 0 -0.481853282 kegg kegg NA NA no no no no no no Cellular senescence Pantothenate and CoA biosynthesis 0 0.422924901 0 kegg kegg NA NA no no no no no dn Cellular senescence Pentose and glucuronate interconversions 0 -0.5256917 0 kegg kegg NA NA no no no no no no Cellular senescence Pentose phosphate pathway 0.484347826 0.648221344 0 kegg kegg NA NA no no no no no no Cellular senescence Phagosome 0.815652174 0.861660079 0.652252252 kegg kegg NA NA no no no no no no Cellular senescence Phenylalanine metabolism 0 -0.415019763 0 kegg kegg NA NA no no no no no no Cellular senescence Phospholipase D signaling pathway 0 0.461462451 0 kegg kegg NA NA no no no no up up Cellular senescence Platinum drug resistance 0 0 -0.538996139 kegg kegg NA NA no no no no no no Cellular senescence Porphyrin and chlorophyll metabolism 0 -0.71541502 0 kegg kegg NA NA no no no no no no Cellular senescence PPAR signaling pathway 0.431304348 0.56916996 0.484684685 kegg kegg NA NA no no no no no no Cellular senescence Primary bile acid biosynthesis -0.414782609 0 0 kegg kegg NA NA no no no no no no Cellular senescence Propanoate metabolism 0 -0.522727273 0 kegg kegg NA NA no no no no no no Cellular senescence Protein export -0.494782609 0 0 kegg kegg NA NA no no no no no no Cellular senescence Protein processing in endoplasmic reticulum 0 -0.589920949 0 kegg kegg NA NA no no no no no no Cellular senescence Purine metabolism 0 -0.672924901 0 kegg kegg NA NA no no no no no no Cellular senescence Pyrimidine metabolism 0 -0.552371542 0 kegg kegg NA NA no no no no no no Cellular senescence Pyruvate metabolism 0 -0.62055336 -0.453024453 kegg kegg NA NA no no no no no no Cellular senescence Retinol metabolism 0 -0.519762846 -0.410810811 kegg kegg NA NA no no no no no no Cellular senescence Ribosome 0 -0.414031621 0 kegg kegg NA NA no no no no no no Cellular senescence Ribosome biogenesis in eukaryotes -0.482608696 -0.578063241 0 kegg kegg NA NA no no no no no no Cellular senescence RNA degradation -0.48 -0.468379447 0 kegg kegg NA NA no no no no no no Cellular senescence RNA polymerase -0.432173913 -0.638339921 0 kegg kegg NA NA no no no no no no Cellular senescence Sarcina 0 0.422326513 0 kegg Genus NA 0.0703 no no no no no no Cellular senescence Selenocompound metabolism -0.519130435 -0.438735178 -0.446846847 kegg kegg NA NA no no no no no no Cellular senescence Sphingolipid signaling pathway 0 0.755928854 0 kegg kegg NA NA no no no no no no Cellular senescence Steroid biosynthesis -0.673043478 -0.574110672 0 kegg kegg NA NA no no no no no no Cellular senescence Steroid hormone biosynthesis 0 -0.622529644 0 kegg kegg NA NA no no no no no no Cellular senescence Sulfur metabolism 0 -0.41798419 0 kegg kegg NA NA no no no no no no Cellular senescence Synthesis and degradation of ketone bodies -0.416521739 -0.706521739 0 kegg kegg NA NA no no no no no no Cellular senescence Taurine and hypotaurine metabolism -0.436521739 0 0 kegg kegg NA NA no no no no no no Cellular senescence Terpenoid backbone biosynthesis -0.682608696 0 0 kegg kegg NA NA no no no no no no Cellular senescence Thiamine metabolism 0 -0.717391304 0 kegg kegg NA NA no no no no no no Cellular senescence Tyrosine metabolism 0 -0.653162055 -0.456370656 kegg kegg NA NA no no no no no no Cellular senescence Ubiquinone and other terpenoid-quinone biosynthesis -0.450434783 -0.586956522 -0.43989704 kegg kegg NA NA no no no no no no Cellular senescence Ubiquitin mediated proteolysis 0 -0.563241107 0 kegg kegg NA NA no no no no no no Cellular senescence "Valine, leucine and isoleucine degradation" 0 -0.574110672 0 kegg kegg NA NA no no no no no no Cellular senescence Viral protein interaction with cytokine and cytokine receptor 0.513913043 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Adherens junction -0.527826087 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer AGE-RAGE signaling pathway in diabetic complications 0 0 0.4996139 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Alcoholism 0 0 -0.444272844 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Aldosterone-regulated sodium reabsorption 0.468695652 0 0.554697555 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Alistipes -0.420091342 0 0 kegg Genus NA 0.0114 no no no no up no Central carbon metabolism in cancer Aminoacyl-tRNA biosynthesis 0 0 0.466409266 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Apoptosis 0 0 -0.466924067 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Apoptosis - multiple species 0.449565217 0 0.543629344 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Arachidonic acid metabolism 0 0 -0.624967825 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Ascorbate and aldarate metabolism 0 0 0.483655084 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Autophagy - animal 0.645217391 0 0.516602317 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Autophagy - other 0.453043478 0 0.582754183 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Bacterial invasion of epithelial cells -0.428695652 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Basal transcription factors 0 0 0.693436293 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Base excision repair 0.455652174 0 0.564478764 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Bile secretion 0 0 -0.435778636 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Biosynthesis of cofactors 0 0 -0.416731017 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Breast cancer 0 0 0.422908623 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Carbohydrate digestion and absorption 0.587826087 0 0.548005148 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Cell cycle 0 0 0.567567568 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Chemokine signaling pathway 0 0 -0.649163449 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Cholinergic synapse 0.515652174 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Circadian rhythm 0 0 0.465894466 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Citrate cycle (TCA cycle) 0 0 0.498069498 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Collinsella 0 0 -0.425370233 kegg Genus NA 0.128 no no no no no no Central carbon metabolism in cancer Colorectal cancer 0 0 0.465894466 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Complement and coagulation cascades 0 0 -0.437580438 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Coprococcus 0.430434783 0 0 butyrate-producing kegg Genus NA 0.612 no no no no no no Central carbon metabolism in cancer Cysteine and methionine metabolism 0.499130435 0 0.568854569 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Cytosolic DNA-sensing pathway 0 0 -0.543371943 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer DNA replication 0 0 0.496525097 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer EGFR tyrosine kinase inhibitor resistance 0 0.549407115 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Endometrial cancer 0 0 0.503732304 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Epithelial cell signaling in Helicobacter pylori infection 0 0 -0.528700129 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer ErbB signaling pathway 0 0 0.535392535 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Ether lipid metabolism -0.426086957 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Fanconi anemia pathway 0 0 0.692664093 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Fatty acid biosynthesis 0.474782609 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Fatty acid degradation 0.513043478 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Ferroptosis 0 0 -0.546203346 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer FoxO signaling pathway 0.72173913 0 0.718918919 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Gap junction 0 0 -0.458944659 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Gastric acid secretion -0.54 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Gastric cancer 0 0 0.627284427 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Gemmiger 0 0.432245513 0 butyrate-producing kegg Genus NA 0.595 no no no no no no Central carbon metabolism in cancer Glioma 0 0 0.623166023 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Glutathione metabolism 0 0 -0.546460746 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Glycerophospholipid metabolism 0 0 0.480823681 kegg kegg NA NA no no no no no up Central carbon metabolism in cancer "Glycine, serine and threonine metabolism" 0 0 -0.427541828 kegg kegg NA NA no no no no up no Central carbon metabolism in cancer Glycosaminoglycan degradation 0 -0.496047431 0 kegg kegg NA NA no no no no no up Central carbon metabolism in cancer Glycosphingolipid biosynthesis - ganglio series -0.503478261 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer GnRH secretion 0 0 0.465894466 kegg kegg NA NA no no no no up up Central carbon metabolism in cancer Hedgehog signaling pathway 0 0 0.593564994 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Hepatitis B 0.519130435 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Hepatocellular carcinoma -0.410434783 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer HIF-1 signaling pathway 0.436521739 0.541501976 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Hippo signaling pathway -0.535652174 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Hippo signaling pathway - multiple species 0 -0.4743083 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Homologous recombination 0.555652174 0 0.68030888 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Human cytomegalovirus infection 0 0 -0.403861004 kegg kegg NA NA no no no no no dn Central carbon metabolism in cancer Influenza A -0.434782609 0 -0.421621622 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Inositol phosphate metabolism 0 0 0.55984556 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Insulin signaling pathway 0 0.480237154 0.425482625 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer JAK-STAT signaling pathway 0.452173913 0 0.423938224 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Kaposi sarcoma-associated herpesvirus infection 0 0 -0.51016731 kegg kegg NA NA no no no no no dn Central carbon metabolism in cancer Legionellosis 0.472173913 0.532608696 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Leishmaniasis 0 0.454545455 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Long-term depression 0 0 -0.43011583 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Long-term potentiation 0 0 0.411068211 kegg kegg NA NA no no no no no up Central carbon metabolism in cancer Longevity regulating pathway - multiple species 0.553043478 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Lysine degradation 0 0 0.517631918 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer MAPK signaling pathway 0.540869565 0 0.547490347 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Measles 0.492173913 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Melanoma 0.440869565 0 0.451737452 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer MicroRNAs in cancer 0 0 0.674131274 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Mineral absorption 0 0 -0.518661519 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Morphine addiction 0 0 -0.467181467 kegg kegg NA NA no no no no up up Central carbon metabolism in cancer mRNA surveillance pathway 0 0 0.493178893 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer mTOR signaling pathway 0 0.52173913 0.409266409 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer N-Glycan biosynthesis 0 0 0.607722008 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Natural killer cell mediated cytotoxicity 0 0 -0.430888031 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Necroptosis 0 0 -0.463320463 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Neutrophil extracellular trap formation 0 0 -0.455855856 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer NOD-like receptor signaling pathway 0.437391304 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Nucleotide excision repair 0 0 0.538738739 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer One carbon pool by folate 0 0 0.491634492 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Oocyte meiosis 0 0 0.543371943 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Other types of O-glycan biosynthesis 0 0 0.613899614 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Ovarian steroidogenesis 0 0 -0.469498069 kegg kegg NA NA no no no no up up Central carbon metabolism in cancer Oxytocin signaling pathway 0 0 -0.409266409 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer p53 signaling pathway 0 0 0.518918919 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Pancreatic cancer 0 0.463438735 0.452767053 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Parabacteroides 0 0 -0.473003412 kegg Genus NA 4.19E-05 no no no no up up Central carbon metabolism in cancer Parkinson disease 0 0 -0.43011583 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Pathogenic Escherichia coli infection 0 0 -0.480823681 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Pathways in cancer 0 0 0.403861004 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Pathways of neurodegeneration - multiple diseases 0 0 -0.440669241 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Peroxisome 0.444347826 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Phagosome 0 0 -0.496267696 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Phosphatidylinositol signaling system 0 0 0.595109395 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer PI3K-Akt signaling pathway 0.62173913 0.657114625 0.618790219 yes kegg kegg NA NA no no no no up up Central carbon metabolism in cancer Platelet activation -0.48 0 -0.434749035 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Platinum drug resistance 0.57826087 0 0.693436293 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Porphyrin and chlorophyll metabolism 0 0 -0.459202059 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Progesterone-mediated oocyte maturation 0.766086957 0 0.675675676 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Propanoate metabolism 0.56173913 0 0.546460746 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Protein digestion and absorption 0 0 0.484427284 yes kegg kegg NA NA no no no no up up Central carbon metabolism in cancer Proteoglycans in cancer 0 0.448616601 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Proximal tubule bicarbonate reclamation 0 0 0.47979408 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Pyruvate metabolism 0.426956522 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Rap1 signaling pathway 0 0 -0.525611326 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Relaxin signaling pathway 0 0 -0.421364221 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Renal cell carcinoma 0 0.537549407 0.446846847 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Retinol metabolism 0 0 0.490862291 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Ribosome biogenesis in eukaryotes 0 0 0.675418275 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer RIG-I-like receptor signaling pathway 0.433043478 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer RNA degradation 0 0 0.581981982 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer RNA polymerase 0 0 0.414671815 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer RNA transport 0.493913043 0.554347826 0.413642214 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Selenocompound metabolism 0 0 0.66023166 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Serotonergic synapse 0 -0.482213439 -0.611840412 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Shigellosis 0 0 -0.414157014 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Signaling pathways regulating pluripotency of stem cells 0 0 0.608751609 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Sphingolipid signaling pathway 0 0 0.429343629 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Spinocerebellar ataxia 0.433913043 0.486166008 0.655598456 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Spliceosome 0.609565217 0 0.702702703 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Sulfur metabolism 0 0 -0.403861004 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Synthesis and degradation of ketone bodies 0 0 0.521235521 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer T cell receptor signaling pathway 0.573913043 0 0.502445302 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Taste transduction 0 0 0.483140283 kegg kegg NA NA no no no no no up Central carbon metabolism in cancer Terpenoid backbone biosynthesis 0 0 0.493178893 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Th1 and Th2 cell differentiation -0.468695652 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Thyroid hormone synthesis 0 0 -0.567310167 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Tight junction -0.62 0 -0.433976834 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Toll-like receptor signaling pathway 0 0 -0.416731017 yes kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Transcriptional misregulation in cancer 0.513043478 0 0 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Tryptophan metabolism 0 0 0.545173745 kegg kegg NA NA no no no no up no Central carbon metabolism in cancer Type I diabetes mellitus 0 0 -0.443243243 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Type II diabetes mellitus 0.486086957 0 0.423680824 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Ubiquinone and other terpenoid-quinone biosynthesis 0 0 0.406949807 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer "Valine, leucine and isoleucine degradation" 0 0 0.465379665 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Various types of N-glycan biosynthesis 0 0 0.665894466 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Vibrio cholerae infection -0.513043478 0 -0.502702703 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Viral carcinogenesis 0 0 -0.403088803 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Viral protein interaction with cytokine and cytokine receptor 0 0 -0.607979408 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Wnt signaling pathway 0 0 0.416988417 kegg kegg NA NA no no no no no no Central carbon metabolism in cancer Yersinia infection 0 0 -0.48030888 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway 2-Oxocarboxylic acid metabolism -0.716521739 -0.674901186 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway "Alanine, aspartate and glutamate metabolism" 0.446086957 0.721343874 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Alistipes -0.47424033 0 0 kegg Genus NA 0.0114 no no no no up no cGMP-PKG signaling pathway alpha-Linolenic acid metabolism 0 0.448616601 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Aminoacyl-tRNA biosynthesis -0.508695652 -0.608695652 -0.525868726 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Antifolate resistance 0 -0.566205534 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Arginine and proline metabolism 0.44173913 0.792490119 0 kegg kegg NA NA no no no no up no cGMP-PKG signaling pathway Arginine biosynthesis 0.476521739 0.747035573 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Basal transcription factors 0 -0.694664032 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Base excision repair 0 -0.661067194 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway beta-Alanine metabolism -0.433913043 0 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Biosynthesis of amino acids 0 0.877470356 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Biosynthesis of cofactors -0.74 -0.645256917 -0.445817246 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Butanoate metabolism -0.60173913 -0.585968379 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Calcium signaling pathway 0 -0.48715415 0 kegg kegg NA NA no no no no up up cGMP-PKG signaling pathway Citrate cycle (TCA cycle) -0.502608696 -0.568181818 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Clostridium 0 0 0.438757958 kegg Genus NA 0.925 no no no no no no cGMP-PKG signaling pathway Cysteine and methionine metabolism 0 -0.52173913 -0.408494208 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway DNA replication 0 -0.782608696 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Drug metabolism - cytochrome P450 0 -0.633399209 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Drug metabolism - other enzymes 0 -0.51284585 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.506916996 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Ether lipid metabolism 0 -0.647233202 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Fanconi anemia pathway 0 -0.65513834 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Fatty acid biosynthesis 0.529565217 0.781620553 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Fatty acid degradation 0 0.551383399 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Fatty acid metabolism 0 0.64229249 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Folate biosynthesis 0 -0.561264822 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Fructose and mannose metabolism -0.406956522 0 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Galactose metabolism 0 0.443675889 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Glutathione metabolism -0.592173913 -0.56027668 -0.462290862 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway "Glycine, serine and threonine metabolism" -0.733913043 -0.568181818 0 kegg kegg NA NA no no no no up no cGMP-PKG signaling pathway Glycolysis / Gluconeogenesis -0.468695652 0 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.472173913 0.47826087 0.494465894 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.447826087 -0.511857708 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0 -0.448616601 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Glycosaminoglycan degradation 0 0.597826087 0.441441441 kegg kegg NA NA no no no no no up cGMP-PKG signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 -0.56916996 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.545454545 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.787549407 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Homologous recombination 0 -0.460474308 -0.402316602 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Lysine degradation 0 -0.600790514 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Mannose type O-glycan biosynthesis 0 -0.555335968 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway MAPK signaling pathway 0.499130435 0 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.518774704 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Mismatch repair 0 -0.539525692 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway mRNA surveillance pathway 0 -0.869565217 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway N-Glycan biosynthesis 0 -0.83201581 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Nicotinate and nicotinamide metabolism 0.610434783 0.850790514 0.579150579 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Nitrogen metabolism 0.407826087 0.73715415 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Non-homologous end-joining -0.444347826 0 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Nucleotide excision repair 0 -0.714426877 -0.448648649 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway One carbon pool by folate 0 -0.721343874 -0.483655084 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Other types of O-glycan biosynthesis 0 -0.593873518 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Oxidative phosphorylation 0 -0.616600791 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Pantothenate and CoA biosynthesis 0.693043478 0.805335968 0.458172458 kegg kegg NA NA no no no no no dn cGMP-PKG signaling pathway Paraprevotella 0 -0.535149679 0 kegg Genus NA 0.118 no no no no no no cGMP-PKG signaling pathway Pentose and glucuronate interconversions 0 -0.72826087 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Pentose phosphate pathway 0 0.918972332 0.422651223 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Phenylalanine metabolism -0.58173913 -0.446640316 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Porphyrin and chlorophyll metabolism -0.689565217 -0.53458498 -0.436036036 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway PPAR signaling pathway 0 0.772727273 0.667953668 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Propanoate metabolism 0 -0.442687747 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Protein export 0 -0.646245059 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Purine metabolism -0.544347826 -0.646245059 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Pyrimidine metabolism 0 -0.626482213 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Pyruvate metabolism 0 -0.59486166 -0.495495495 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Ras signaling pathway 0 -0.553359684 0 yes kegg kegg NA NA no no no no up up cGMP-PKG signaling pathway Retinol metabolism 0 -0.443675889 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Ribosome 0 -0.53458498 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Ribosome biogenesis in eukaryotes 0 -0.82312253 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway RNA degradation 0 -0.824110672 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway RNA polymerase 0 -0.894268775 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway RNA transport 0 -0.441699605 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Ruminococcus -0.531304348 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no cGMP-PKG signaling pathway Selenocompound metabolism 0 -0.450592885 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Slackia 0 0 -0.463976098 kegg Genus NA 0.94 no no no no no no cGMP-PKG signaling pathway Spliceosome 0 -0.470355731 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Starch and sucrose metabolism 0 0.736166008 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Synthesis and degradation of ketone bodies 0 -0.596837945 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Terpenoid backbone biosynthesis 0 -0.469367589 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Thiamine metabolism 0 -0.453557312 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Tryptophan metabolism -0.417391304 0 0 kegg kegg NA NA no no no no up no cGMP-PKG signaling pathway Tyrosine metabolism -0.415652174 -0.48715415 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.549407115 -0.465379665 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway "Valine, leucine and isoleucine degradation" -0.471304348 -0.583003953 0 kegg kegg NA NA no no no no no no cGMP-PKG signaling pathway Various types of N-glycan biosynthesis 0 -0.718379447 0 kegg kegg NA NA no no no no no no Chagas disease 2-Oxocarboxylic acid metabolism -0.476521739 -0.698616601 0 kegg kegg NA NA no no no no no no Chagas disease Adherens junction 0 -0.556324111 0 kegg kegg NA NA no no no no no no Chagas disease Adipocytokine signaling pathway 0.419130435 0.802371542 0 kegg kegg NA NA no no no no no no Chagas disease Adrenergic signaling in cardiomyocytes 0.445217391 0 0 kegg kegg NA NA no no no no no up Chagas disease AGE-RAGE signaling pathway in diabetic complications 0 0.690711462 0 kegg kegg NA NA no no no no no no Chagas disease "Alanine, aspartate and glutamate metabolism" 0 0.709486166 0 kegg kegg NA NA no no no no no no Chagas disease Alcoholism 0 0 0.503732304 kegg kegg NA NA no no no no no no Chagas disease Aldosterone-regulated sodium reabsorption 0.594782609 0.415019763 0 kegg kegg NA NA no no no no no no Chagas disease alpha-Linolenic acid metabolism 0 0 -0.471814672 kegg kegg NA NA no no no no no no Chagas disease Alzheimer disease 0 -0.466403162 0 kegg kegg NA NA no no no no no no Chagas disease Amino sugar and nucleotide sugar metabolism -0.432173913 0 -0.71016731 kegg kegg NA NA no no no no no no Chagas disease Aminoacyl-tRNA biosynthesis 0 -0.600790514 -0.400772201 kegg kegg NA NA no no no no no no Chagas disease Amphetamine addiction 0 -0.572134387 0 kegg kegg NA NA no no no no no no Chagas disease Amyotrophic lateral sclerosis 0 -0.514822134 0 kegg kegg NA NA no no no no no no Chagas disease Antifolate resistance 0 -0.428853755 -0.423423423 kegg kegg NA NA no no no no no no Chagas disease Apelin signaling pathway 0 -0.688735178 0 kegg kegg NA NA no no no no no no Chagas disease Apoptosis 0 0.79743083 0 kegg kegg NA NA no no no no no no Chagas disease Apoptosis - multiple species 0 0 -0.479279279 kegg kegg NA NA no no no no no no Chagas disease Arachidonic acid metabolism -0.542608696 0 0 kegg kegg NA NA no no no no no no Chagas disease Arginine and proline metabolism 0 0.670948617 0 kegg kegg NA NA no no no no up no Chagas disease Arginine biosynthesis 0 0.731225296 0 kegg kegg NA NA no no no no no no Chagas disease Ascorbate and aldarate metabolism -0.473913043 -0.529644269 -0.612355212 kegg kegg NA NA no no no no no no Chagas disease Autophagy - animal 0.52 0.804347826 0 kegg kegg NA NA no no no no no no Chagas disease Autophagy - other 0.45826087 0 0 kegg kegg NA NA no no no no no no Chagas disease B cell receptor signaling pathway 0 0.787549407 0.424453024 kegg kegg NA NA no no no no no no Chagas disease Bacterial invasion of epithelial cells 0 -0.484189723 0 kegg kegg NA NA no no no no no no Chagas disease Bacteroides 0 -0.473320158 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Chagas disease Basal transcription factors 0 -0.496047431 0 kegg kegg NA NA no no no no no no Chagas disease Base excision repair 0 -0.461462451 -0.516087516 kegg kegg NA NA no no no no no no Chagas disease beta-Alanine metabolism -0.605217391 -0.670948617 -0.634749035 kegg kegg NA NA no no no no no no Chagas disease Biosynthesis of amino acids 0 0.473320158 0 kegg kegg NA NA no no no no no no Chagas disease Biosynthesis of cofactors -0.433913043 -0.556324111 0 kegg kegg NA NA no no no no no no Chagas disease Biosynthesis of unsaturated fatty acids -0.550434783 -0.598814229 -0.596911197 kegg kegg NA NA no no no no no no Chagas disease Butanoate metabolism -0.597391304 -0.909090909 -0.568854569 kegg kegg NA NA no no no no no no Chagas disease Butyricimonas 0.45902689 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Chagas disease C-type lectin receptor signaling pathway 0.58173913 0.824110672 0.461261261 kegg kegg NA NA no no no no no no Chagas disease Calcium signaling pathway 0 0 0.453796654 kegg kegg NA NA no no no no up up Chagas disease cAMP signaling pathway 0.640869565 0.803359684 0.717374517 yes kegg kegg NA NA no no no no up up Chagas disease Carbohydrate digestion and absorption 0.703478261 0.539525692 0 kegg kegg NA NA no no no no no no Chagas disease Carbon metabolism -0.437391304 0 0 kegg kegg NA NA no no no no no no Chagas disease Cardiac muscle contraction 0 -0.435770751 0 kegg kegg NA NA no no no no no up Chagas disease Cell cycle 0 -0.624505929 0 kegg kegg NA NA no no no no no no Chagas disease Cellular senescence 0 0.564229249 0.561904762 kegg kegg NA NA no no no no no no Chagas disease cGMP-PKG signaling pathway 0 0.555335968 0 kegg kegg NA NA no no no no no no Chagas disease Chemokine signaling pathway 0.63826087 0.623517787 0.510939511 kegg kegg NA NA no no no no no no Chagas disease Cholinergic synapse 0.480869565 0 0 kegg kegg NA NA no no no no no no Chagas disease Circadian entrainment 0 -0.507905138 0 kegg kegg NA NA no no no no up up Chagas disease Circadian rhythm 0.406956522 0 0 kegg kegg NA NA no no no no no no Chagas disease Citrate cycle (TCA cycle) -0.611304348 -0.911067194 -0.427799228 kegg kegg NA NA no no no no no no Chagas disease Clostridium -0.449228104 0 0 kegg Genus NA 0.925 no no no no no no Chagas disease Cocaine addiction 0 0 0.611068211 kegg kegg NA NA no no no no no no Chagas disease Complement and coagulation cascades 0 0.440711462 0 kegg kegg NA NA no no no no no no Chagas disease Cortisol synthesis and secretion 0 0 0.453796654 kegg kegg NA NA no no no no no up Chagas disease Cysteine and methionine metabolism 0 -0.902173913 0 kegg kegg NA NA no no no no no no Chagas disease Cytosolic DNA-sensing pathway 0.566086957 0.70256917 0.770913771 kegg kegg NA NA no no no no no no Chagas disease DNA replication 0 -0.867588933 -0.477734878 kegg kegg NA NA no no no no no no Chagas disease Dopaminergic synapse 0.435652174 -0.427865613 0 kegg kegg NA NA no no no no up no Chagas disease Drug metabolism - cytochrome P450 0 -0.913043478 -0.457915058 kegg kegg NA NA no no no no no no Chagas disease Drug metabolism - other enzymes -0.646956522 -0.862648221 -0.42033462 kegg kegg NA NA no no no no no no Chagas disease ECM-receptor interaction 0 -0.554347826 0 kegg kegg NA NA no no no no up up Chagas disease EGFR tyrosine kinase inhibitor resistance 0 -0.567193676 0 kegg kegg NA NA no no no no no no Chagas disease Endocytosis 0 0 0.489060489 kegg kegg NA NA no no no no no no Chagas disease Epithelial cell signaling in Helicobacter pylori infection 0.520869565 0.805335968 0.708108108 kegg kegg NA NA no no no no no no Chagas disease ErbB signaling pathway 0.479130435 0.517786561 0 kegg kegg NA NA no no no no no no Chagas disease Estrogen signaling pathway 0 -0.758893281 0 kegg kegg NA NA no no no no no no Chagas disease Ether lipid metabolism 0 -0.433794466 -0.563449163 kegg kegg NA NA no no no no no no Chagas disease Fanconi anemia pathway 0 -0.435770751 -0.531016731 kegg kegg NA NA no no no no no no Chagas disease Fatty acid biosynthesis 0 0.669960474 0 kegg kegg NA NA no no no no no no Chagas disease Fatty acid degradation 0 0 -0.403603604 kegg kegg NA NA no no no no no no Chagas disease Fatty acid elongation -0.656521739 -0.663043478 -0.540797941 kegg kegg NA NA no no no no no no Chagas disease Fatty acid metabolism -0.408695652 0 0 kegg kegg NA NA no no no no no no Chagas disease Fc epsilon RI signaling pathway 0 0.809288538 0 kegg kegg NA NA no no no no no no Chagas disease Ferroptosis 0 0.4743083 0 kegg kegg NA NA no no no no no no Chagas disease Focal adhesion 0 -0.644268775 0 kegg kegg NA NA no no no no up up Chagas disease Folate biosynthesis 0 -0.486166008 0 kegg kegg NA NA no no no no no no Chagas disease FoxO signaling pathway 0 0.43083004 0 kegg kegg NA NA no no no no no no Chagas disease Fructose and mannose metabolism 0 0.453557312 0 kegg kegg NA NA no no no no no no Chagas disease GABAergic synapse 0 0.528656126 0 kegg kegg NA NA no no no no up up Chagas disease Galactose metabolism -0.426086957 0 -0.465379665 kegg kegg NA NA no no no no no no Chagas disease Gap junction 0 0 0.411583012 kegg kegg NA NA no no no no no no Chagas disease Gastric acid secretion 0 -0.567193676 0 kegg kegg NA NA no no no no no no Chagas disease Glucagon signaling pathway 0 -0.538537549 0 kegg kegg NA NA no no no no no no Chagas disease Glutamatergic synapse 0 0.543478261 0 kegg kegg NA NA no no no no up up Chagas disease Glutathione metabolism 0 -0.548418972 0 kegg kegg NA NA no no no no no no Chagas disease Glycerophospholipid metabolism 0 0 -0.453024453 kegg kegg NA NA no no no no no up Chagas disease Glycolysis / Gluconeogenesis -0.41826087 -0.750988142 -0.423166023 kegg kegg NA NA no no no no no no Chagas disease Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.809288538 0 kegg kegg NA NA no no no no no no Chagas disease Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.466086957 -0.508893281 0 kegg kegg NA NA no no no no no no Chagas disease Glycosphingolipid biosynthesis - ganglio series -0.442608696 -0.485177866 -0.466409266 kegg kegg NA NA no no no no no no Chagas disease Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.5 0 kegg kegg NA NA no no no no no no Chagas disease Glyoxylate and dicarboxylate metabolism 0 0.717391304 0 kegg kegg NA NA no no no no no no Chagas disease GnRH secretion 0.522608696 0.619565217 0 kegg kegg NA NA no no no no up up Chagas disease GnRH signaling pathway 0 0 0.417245817 kegg kegg NA NA no no no no no no Chagas disease "Growth hormone synthesis, secretion and action" 0.50173913 0.564229249 0.580694981 kegg kegg NA NA no no no no no no Chagas disease Hedgehog signaling pathway 0 -0.440711462 0 kegg kegg NA NA no no no no no no Chagas disease Hematopoietic cell lineage -0.565217391 -0.690711462 -0.607722008 kegg kegg NA NA no no no no no no Chagas disease HIF-1 signaling pathway 0 -0.600790514 0 kegg kegg NA NA no no no no no no Chagas disease Hippo signaling pathway 0 -0.665019763 0 kegg kegg NA NA no no no no no no Chagas disease Hippo signaling pathway - multiple species 0 0.490118577 0 kegg kegg NA NA no no no no no no Chagas disease Histidine metabolism -0.555652174 0 -0.624195624 kegg kegg NA NA no no no no no no Chagas disease Homologous recombination 0 0 -0.52972973 kegg kegg NA NA no no no no no no Chagas disease Huntington disease 0 -0.448616601 0 kegg kegg NA NA no no no no no no Chagas disease IL-17 signaling pathway 0 0.570158103 0 kegg kegg NA NA no no no no no no Chagas disease Inflammatory mediator regulation of TRP channels 0 -0.515810277 0 kegg kegg NA NA no no no no no no Chagas disease Inositol phosphate metabolism 0 0 -0.546975547 kegg kegg NA NA no no no no no no Chagas disease Insulin resistance 0.529565217 0.813241107 0 kegg kegg NA NA no no no no no no Chagas disease Insulin secretion 0 0 0.476447876 yes kegg kegg NA NA no no no no up up Chagas disease Insulin signaling pathway 0 -0.674901186 0 kegg kegg NA NA no no no no no no Chagas disease JAK-STAT signaling pathway 0 0.658102767 0 kegg kegg NA NA no no no no no no Chagas disease Long-term depression 0 0.473320158 0.550836551 kegg kegg NA NA no no no no no no Chagas disease Long-term potentiation 0 -0.744071146 0 kegg kegg NA NA no no no no no up Chagas disease Maturity onset diabetes of the young 0 0 -0.472586873 kegg kegg NA NA no no no no up no Chagas disease Melanogenesis 0 -0.468379447 0 kegg kegg NA NA no no no no no no Chagas disease Metabolism of xenobiotics by cytochrome P450 -0.48 -0.908102767 -0.427541828 kegg kegg NA NA no no no no no no Chagas disease Mismatch repair -0.483478261 -0.843873518 -0.509137709 kegg kegg NA NA no no no no no no Chagas disease Morphine addiction 0 0 0.406692407 kegg kegg NA NA no no no no up up Chagas disease mRNA surveillance pathway 0 -0.41798419 0 kegg kegg NA NA no no no no no no Chagas disease mTOR signaling pathway 0 -0.563241107 0 kegg kegg NA NA no no no no no no Chagas disease N-Glycan biosynthesis 0 -0.763833992 0 kegg kegg NA NA no no no no no no Chagas disease Natural killer cell mediated cytotoxicity 0 0.453557312 0.48030888 kegg kegg NA NA no no no no no no Chagas disease Neurotrophin signaling pathway 0.650434783 0.751976285 0.623423423 kegg kegg NA NA no no no no no no Chagas disease NF-kappa B signaling pathway 0 0.852766798 0.432432432 kegg kegg NA NA no no no no no no Chagas disease Nicotinate and nicotinamide metabolism 0 0.718379447 0 kegg kegg NA NA no no no no no no Chagas disease Nitrogen metabolism 0 0.730237154 0 kegg kegg NA NA no no no no no no Chagas disease NOD-like receptor signaling pathway 0 0.739130435 0 kegg kegg NA NA no no no no no no Chagas disease Non-homologous end-joining -0.606956522 -0.783596838 0 kegg kegg NA NA no no no no no no Chagas disease Notch signaling pathway 0 0.46541502 0 kegg kegg NA NA no no no no no no Chagas disease Nucleotide excision repair -0.434782609 -0.791501976 -0.598198198 kegg kegg NA NA no no no no no no Chagas disease One carbon pool by folate -0.425217391 -0.800395257 -0.54980695 kegg kegg NA NA no no no no no no Chagas disease Oocyte meiosis 0 -0.820158103 0 kegg kegg NA NA no no no no no no Chagas disease Osteoclast differentiation 0 0.671936759 0.421106821 kegg kegg NA NA no no no no no no Chagas disease Other glycan degradation 0 0 -0.423680824 kegg kegg NA NA no no no no no no Chagas disease Other types of O-glycan biosynthesis 0 0 -0.436293436 kegg kegg NA NA no no no no no no Chagas disease Ovarian steroidogenesis 0 0 0.403346203 kegg kegg NA NA no no no no up up Chagas disease Oxidative phosphorylation 0 -0.459486166 0 kegg kegg NA NA no no no no no no Chagas disease p53 signaling pathway 0 0 -0.431145431 kegg kegg NA NA no no no no no no Chagas disease Pantothenate and CoA biosynthesis 0 0.492094862 0 kegg kegg NA NA no no no no no dn Chagas disease "Parathyroid hormone synthesis, secretion and action" 0.489565217 0 0 kegg kegg NA NA no no no no no no Chagas disease Pentose and glucuronate interconversions -0.55826087 -0.863636364 0 kegg kegg NA NA no no no no no no Chagas disease Pentose phosphate pathway 0 0.414031621 0 kegg kegg NA NA no no no no no no Chagas disease Peroxisome 0 0.436758893 0 kegg kegg NA NA no no no no no no Chagas disease Pertussis 0 0.480237154 0 kegg kegg NA NA no no no no no dn Chagas disease Phenylalanine metabolism -0.568695652 -0.807312253 -0.408236808 kegg kegg NA NA no no no no no no Chagas disease Phospholipase D signaling pathway 0.51826087 0.874505929 0.53024453 kegg kegg NA NA no no no no up up Chagas disease Phototransduction 0 -0.709486166 0 kegg kegg NA NA no no no no no no Chagas disease Platelet activation 0 -0.421936759 0 kegg kegg NA NA no no no no no no Chagas disease Platinum drug resistance 0 0 -0.493693694 kegg kegg NA NA no no no no no no Chagas disease PPAR signaling pathway 0 0.7243083 0.561389961 kegg kegg NA NA no no no no no no Chagas disease Primary bile acid biosynthesis -0.651304348 -0.693675889 -0.451994852 kegg kegg NA NA no no no no no no Chagas disease Prion disease 0 -0.563241107 0 kegg kegg NA NA no no no no no no Chagas disease Prolactin signaling pathway 0.612173913 0.720355731 0 kegg kegg NA NA no no no no no no Chagas disease Propanoate metabolism 0 -0.873517787 0 kegg kegg NA NA no no no no no no Chagas disease Proteasome 0 -0.756916996 0 kegg kegg NA NA no no no no no no Chagas disease Protein export 0 -0.703557312 0 kegg kegg NA NA no no no no no no Chagas disease Protein processing in endoplasmic reticulum 0 -0.669960474 0 kegg kegg NA NA no no no no no no Chagas disease Proximal tubule bicarbonate reclamation 0 -0.863636364 0 kegg kegg NA NA no no no no no no Chagas disease Pyrimidine metabolism -0.62 -0.760869565 -0.528442728 kegg kegg NA NA no no no no no no Chagas disease Pyruvate metabolism -0.446086957 -0.897233202 -0.46048906 kegg kegg NA NA no no no no no no Chagas disease Ras signaling pathway 0 -0.705533597 0 yes kegg kegg NA NA no no no no up up Chagas disease Regulation of actin cytoskeleton 0 -0.650197628 0 kegg kegg NA NA no no no no no no Chagas disease Relaxin signaling pathway 0.74 0.863636364 0.653539254 kegg kegg NA NA no no no no no no Chagas disease Renin secretion 0 -0.581027668 0 kegg kegg NA NA no no no no no no Chagas disease Renin-angiotensin system 0 0.444664032 0 kegg kegg NA NA no no no no no no Chagas disease Retinol metabolism 0 -0.681818182 -0.603088803 kegg kegg NA NA no no no no no no Chagas disease Retrograde endocannabinoid signaling 0 -0.541501976 0 kegg kegg NA NA no no no no no up Chagas disease Ribosome 0 -0.535573123 0 kegg kegg NA NA no no no no no no Chagas disease Ribosome biogenesis in eukaryotes 0 -0.617588933 0 kegg kegg NA NA no no no no no no Chagas disease RIG-I-like receptor signaling pathway 0.597391304 0.864624506 0.537194337 kegg kegg NA NA no no no no no no Chagas disease RNA degradation 0 -0.664031621 0 kegg kegg NA NA no no no no no no Chagas disease RNA polymerase 0 -0.669960474 -0.416731017 kegg kegg NA NA no no no no no no Chagas disease RNA transport 0 -0.552371542 0 kegg kegg NA NA no no no no no no Chagas disease Selenocompound metabolism 0 0 -0.606949807 kegg kegg NA NA no no no no no no Chagas disease Serotonergic synapse 0 0 0.51016731 kegg kegg NA NA no no no no no no Chagas disease Signaling pathways regulating pluripotency of stem cells 0.431304348 0 0 kegg kegg NA NA no no no no no no Chagas disease SNARE interactions in vesicular transport 0 0.468379447 0 kegg kegg NA NA no no no no no no Chagas disease Sphingolipid signaling pathway 0.515652174 0.459486166 0 kegg kegg NA NA no no no no no no Chagas disease Spinocerebellar ataxia 0.428695652 -0.432806324 0 kegg kegg NA NA no no no no no no Chagas disease Starch and sucrose metabolism 0 0.519762846 0 kegg kegg NA NA no no no no no no Chagas disease Steroid biosynthesis 0 -0.787549407 -0.533848134 kegg kegg NA NA no no no no no no Chagas disease Steroid hormone biosynthesis -0.53826087 -0.795454545 -0.48983269 kegg kegg NA NA no no no no no no Chagas disease Sulfur metabolism -0.530434783 -0.425889328 0 kegg kegg NA NA no no no no no no Chagas disease Synthesis and degradation of ketone bodies -0.466086957 -0.765810277 -0.477220077 kegg kegg NA NA no no no no no no Chagas disease T cell receptor signaling pathway 0.462608696 0.477272727 0.403861004 kegg kegg NA NA no no no no no no Chagas disease Taste transduction 0 -0.650197628 -0.402831403 kegg kegg NA NA no no no no no up Chagas disease Taurine and hypotaurine metabolism 0 0.508893281 0 kegg kegg NA NA no no no no no no Chagas disease Terpenoid backbone biosynthesis 0 -0.509881423 0 kegg kegg NA NA no no no no no no Chagas disease TGF-beta signaling pathway 0 -0.710474308 0 kegg kegg NA NA no no no no no no Chagas disease Thermogenesis 0 -0.530632411 0 kegg kegg NA NA no no no no no no Chagas disease Thiamine metabolism 0 -0.685770751 0 kegg kegg NA NA no no no no no no Chagas disease Thyroid hormone signaling pathway 0 -0.436758893 0 kegg kegg NA NA no no no no no no Chagas disease Tight junction -0.436521739 -0.508893281 0 kegg kegg NA NA no no no no no no Chagas disease TNF signaling pathway 0.848695652 0.873517787 0.722779923 kegg kegg NA NA no no no no no no Chagas disease Toll-like receptor signaling pathway 0.846956522 0.871541502 0.757786358 yes kegg kegg NA NA no no no no no no Chagas disease Tryptophan metabolism -0.692173913 -0.829051383 -0.534620335 kegg kegg NA NA no no no no up no Chagas disease Type II diabetes mellitus 0.646086957 0.618577075 0 kegg kegg NA NA no no no no no no Chagas disease Tyrosine metabolism -0.568695652 -0.889328063 -0.579407979 kegg kegg NA NA no no no no no no Chagas disease Ubiquinone and other terpenoid-quinone biosynthesis -0.72173913 -0.773715415 -0.579150579 kegg kegg NA NA no no no no no no Chagas disease "Valine, leucine and isoleucine degradation" -0.629565217 -0.85770751 -0.642728443 kegg kegg NA NA no no no no no no Chagas disease Various types of N-glycan biosynthesis 0 -0.648221344 0 kegg kegg NA NA no no no no no no Chagas disease Vascular smooth muscle contraction 0 -0.428853755 0 kegg kegg NA NA no no no no no no Chagas disease VEGF signaling pathway 0.512173913 0.600790514 0 kegg kegg NA NA no no no no no no Chagas disease Vibrio cholerae infection 0 -0.431818182 0 kegg kegg NA NA no no no no no no Chagas disease Viral protein interaction with cytokine and cytokine receptor 0.46 0 0 kegg kegg NA NA no no no no no no Chagas disease Wnt signaling pathway 0 -0.692687747 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Adrenergic signaling in cardiomyocytes -0.505217391 -0.516798419 -0.591505792 kegg kegg NA NA no no no no no up Chemical carcinogenesis - DNA adducts Aldosterone synthesis and secretion -0.653913043 -0.583992095 -0.547747748 kegg kegg NA NA no no no no up up Chemical carcinogenesis - DNA adducts alpha-Linolenic acid metabolism 0.667826087 0.549407115 0.551608752 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Alzheimer disease -0.459130435 -0.5 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Amino sugar and nucleotide sugar metabolism 0.813043478 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Aminoacyl-tRNA biosynthesis 0.432173913 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Amphetamine addiction -0.475652174 0 -0.523809524 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts AMPK signaling pathway 0 -0.505928854 -0.457657658 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Amyotrophic lateral sclerosis -0.526956522 -0.502964427 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Antigen processing and presentation 0.450434783 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Apoptosis 0 0 0.514028314 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Arginine and proline metabolism 0.606956522 0.488142292 0.462290862 kegg kegg NA NA no no no no up no Chemical carcinogenesis - DNA adducts Axon guidance -0.48173913 0 0 kegg kegg NA NA no no no no up up Chemical carcinogenesis - DNA adducts Basal transcription factors 0 0 -0.422651223 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts beta-Alanine metabolism 0.576521739 0.562252964 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Bile secretion -0.435652174 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Biosynthesis of amino acids 0.573043478 0.504940711 0.613899614 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Biosynthesis of unsaturated fatty acids 0.566956522 0.501976285 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Calcium signaling pathway -0.74173913 -0.686758893 -0.55984556 kegg kegg NA NA no no no no up up Chemical carcinogenesis - DNA adducts cAMP signaling pathway -0.490434783 0 0 yes kegg kegg NA NA no no no no up up Chemical carcinogenesis - DNA adducts Carbon metabolism 0.610434783 0.434782609 0.723294723 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Cardiac muscle contraction -0.47826087 -0.523715415 0 kegg kegg NA NA no no no no no up Chemical carcinogenesis - DNA adducts Cell cycle 0 0 -0.584555985 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts cGMP-PKG signaling pathway 0 0.496047431 0.427027027 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Cholesterol metabolism 0 0 0.51016731 yes kegg kegg NA NA no no no no no up Chemical carcinogenesis - DNA adducts Circadian rhythm -0.460869565 -0.668972332 -0.522779923 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Citrate cycle (TCA cycle) 0.483478261 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Cocaine addiction -0.606086957 -0.532608696 -0.410810811 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Collecting duct acid secretion 0 0.612648221 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Complement and coagulation cascades 0.466086957 0.437747036 0.491377091 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Coronavirus disease - COVID-19 -0.48 -0.414031621 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Cortisol synthesis and secretion -0.582608696 -0.468379447 -0.471042471 kegg kegg NA NA no no no no no up Chemical carcinogenesis - DNA adducts Cushing syndrome -0.631304348 -0.583003953 -0.649420849 kegg kegg NA NA no no no no no up Chemical carcinogenesis - DNA adducts Cysteine and methionine metabolism 0.473043478 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Cytokine-cytokine receptor interaction 0 0.550395257 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Dopaminergic synapse 0 0 -0.518404118 kegg kegg NA NA no no no no up no Chemical carcinogenesis - DNA adducts Drug metabolism - cytochrome P450 0.733043478 0 0.653796654 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Drug metabolism - other enzymes 0.73826087 0 0.554697555 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts ECM-receptor interaction 0 0 -0.45971686 kegg kegg NA NA no no no no up up Chemical carcinogenesis - DNA adducts Endocrine and other factor-regulated calcium reabsorption -0.595652174 -0.476284585 -0.463320463 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Endocrine resistance -0.676521739 -0.470355731 -0.556756757 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts ErbB signaling pathway -0.64 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Ether lipid metabolism -0.494782609 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Fat digestion and absorption 0.626086957 0.518774704 0.85045045 yes kegg kegg NA NA no no no no up up Chemical carcinogenesis - DNA adducts Fatty acid degradation 0.595652174 0.496047431 0.426512227 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Fatty acid elongation 0.540869565 0.490118577 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Fatty acid metabolism 0.643478261 0.579051383 0.446589447 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Fc epsilon RI signaling pathway -0.496521739 0 0.438610039 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Fc gamma R-mediated phagocytosis 0.524347826 0.561264822 0.463320463 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Folate biosynthesis 0 -0.477272727 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Fructose and mannose metabolism 0.595652174 0 0.476447876 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Galactose metabolism 0.567826087 0 0.432689833 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Glucagon signaling pathway 0 -0.493083004 -0.641184041 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Glycolysis / Gluconeogenesis 0.682608696 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Glycosaminoglycan biosynthesis - keratan sulfate -0.873913043 -0.726284585 -0.508365508 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Glycosaminoglycan degradation 0 0.434782609 0.465637066 kegg kegg NA NA no no no no no up Chemical carcinogenesis - DNA adducts Glycosphingolipid biosynthesis - globo and isoglobo series 0.412173913 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Glycosphingolipid biosynthesis - lacto and neolacto series -0.673913043 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts GnRH secretion -0.629565217 0 0 kegg kegg NA NA no no no no up up Chemical carcinogenesis - DNA adducts GnRH signaling pathway -0.58 -0.553359684 -0.509137709 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts "Growth hormone synthesis, secretion and action" -0.576521739 0 -0.408494208 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Hedgehog signaling pathway -0.651304348 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Hippo signaling pathway - multiple species 0 0.454545455 0.471042471 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Histidine metabolism 0.592173913 0.665019763 0.447361647 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Homologous recombination 0 0 -0.442213642 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Huntington disease -0.51826087 -0.507905138 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts IL-17 signaling pathway 0 0 0.552380952 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Inflammatory mediator regulation of TRP channels -0.537391304 -0.498023715 -0.638352638 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Insulin resistance -0.406956522 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Insulin secretion -0.712173913 -0.576086957 -0.476705277 yes kegg kegg NA NA no no no no up up Chemical carcinogenesis - DNA adducts Kaposi sarcoma-associated herpesvirus infection -0.480869565 0 0 kegg kegg NA NA no no no no no dn Chemical carcinogenesis - DNA adducts Legionellosis 0.542608696 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Leishmaniasis 0.565217391 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Leukocyte transendothelial migration 0 0 0.442471042 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Long-term depression -0.635652174 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Longevity regulating pathway -0.626956522 0 -0.466151866 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Longevity regulating pathway - multiple species 0 0.514822134 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Lysosome 0 0.423913043 0.724066924 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Mannose type O-glycan biosynthesis -0.852173913 -0.548418972 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Melanogenesis -0.491304348 -0.488142292 -0.621621622 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Metabolism of xenobiotics by cytochrome P450 0.782608696 0 0.706306306 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Mismatch repair 0.472173913 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Mitophagy - animal -0.428695652 -0.433794466 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Morphine addiction -0.54 0 0 kegg kegg NA NA no no no no up up Chemical carcinogenesis - DNA adducts mRNA surveillance pathway -0.593913043 -0.636363636 -0.507593308 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Mucin type O-glycan biosynthesis 0.593913043 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts N-Glycan biosynthesis 0 0 -0.467181467 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Neuroactive ligand-receptor interaction 0.516521739 0.485177866 0.602316602 kegg kegg NA NA no no no up up up Chemical carcinogenesis - DNA adducts Neurotrophin signaling pathway -0.459130435 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Neutrophil extracellular trap formation 0.444347826 0.51284585 0.659202059 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Nicotinate and nicotinamide metabolism 0.451304348 0 0.596396396 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts NOD-like receptor signaling pathway 0.55826087 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Non-alcoholic fatty liver disease -0.514782609 -0.508893281 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Non-homologous end-joining 0.52173913 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Notch signaling pathway -0.552173913 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Olfactory transduction 0.425217391 0.736166008 0.638352638 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Oocyte meiosis 0 0 -0.474903475 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Osteoclast differentiation 0 0 0.483655084 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Other glycan degradation 0.440869565 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Oxidative phosphorylation -0.437391304 -0.492094862 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts p53 signaling pathway 0 0 -0.519176319 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Pancreatic secretion -0.622608696 0 -0.401544402 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Pantothenate and CoA biosynthesis 0 0.544466403 0.571171171 kegg kegg NA NA no no no no no dn Chemical carcinogenesis - DNA adducts "Parathyroid hormone synthesis, secretion and action" -0.48 -0.460474308 -0.598198198 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Parkinson disease -0.54173913 -0.464426877 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Pathogenic Escherichia coli infection 0 0.434782609 0.593822394 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Pathways in cancer -0.497391304 0 -0.554697555 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Pathways of neurodegeneration - multiple diseases -0.550434783 -0.47826087 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Pentose and glucuronate interconversions 0.508695652 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Pentose phosphate pathway 0 0.497035573 0.641956242 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Peroxisome 0.526086957 0.449604743 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Pertussis 0.47826087 0.562252964 0.432947233 kegg kegg NA NA no no no no no dn Chemical carcinogenesis - DNA adducts Phagosome 0 0 0.541312741 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Phosphatidylinositol signaling system -0.583478261 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Phospholipase D signaling pathway -0.576521739 0 0 kegg kegg NA NA no no no no up up Chemical carcinogenesis - DNA adducts Primary bile acid biosynthesis 0.567826087 0 0.442213642 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Propanoate metabolism 0.609565217 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Protein digestion and absorption 0 0.420948617 0 yes kegg kegg NA NA no no no no up up Chemical carcinogenesis - DNA adducts Protein processing in endoplasmic reticulum 0 0 -0.558558559 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Pyrimidine metabolism 0.7 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Pyruvate metabolism 0.512173913 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Regulation of actin cytoskeleton 0.425217391 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Regulation of lipolysis in adipocytes 0 0 -0.419047619 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Relaxin signaling pathway -0.516521739 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Renin secretion 0 0 -0.453796654 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Renin-angiotensin system 0 0 0.419305019 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Retinol metabolism 0.757391304 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Ribosome -0.495652174 -0.420948617 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts RNA degradation -0.593913043 -0.486166008 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Salmonella infection 0.614782609 0.581027668 0.486486486 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Signaling pathways regulating pluripotency of stem cells -0.623478261 -0.623517787 -0.513513514 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Sphingolipid metabolism 0 0 0.535907336 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Spinocerebellar ataxia 0 -0.53458498 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Spliceosome 0 0 -0.47001287 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Staphylococcus aureus infection 0 0.515810277 0.506563707 kegg kegg NA NA no no no up no no Chemical carcinogenesis - DNA adducts Starch and sucrose metabolism 0.647826087 0.420948617 0.614157014 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Steroid hormone biosynthesis 0.734782609 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Synaptic vesicle cycle 0 0.633399209 0.648133848 kegg kegg NA NA no no no no up up Chemical carcinogenesis - DNA adducts Synthesis and degradation of ketone bodies 0.406086957 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts T cell receptor signaling pathway 0 0 -0.406177606 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts TGF-beta signaling pathway -0.446956522 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Thermogenesis -0.514782609 -0.488142292 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Thyroid hormone synthesis 0 -0.444664032 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Toxoplasmosis 0.447826087 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Tryptophan metabolism 0.526956522 0 0 kegg kegg NA NA no no no no up no Chemical carcinogenesis - DNA adducts Tuberculosis 0 0.56916996 0.636550837 kegg kegg NA NA no no no no no dn Chemical carcinogenesis - DNA adducts Tyrosine metabolism 0.54173913 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Ubiquinone and other terpenoid-quinone biosynthesis 0.529565217 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Ubiquitin mediated proteolysis -0.520869565 -0.434782609 -0.406949807 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts "Valine, leucine and isoleucine degradation" 0.48 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Vascular smooth muscle contraction -0.451304348 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Vasopressin-regulated water reabsorption -0.527826087 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts VEGF signaling pathway -0.534782609 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Vitamin digestion and absorption -0.54173913 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Wnt signaling pathway -0.728695652 -0.497035573 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - DNA adducts Yersinia infection 0 0.492094862 0.401287001 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation 2-Oxocarboxylic acid metabolism -0.463478261 0 -0.480566281 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation ABC transporters 0 0.482213439 0 kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation Adrenergic signaling in cardiomyocytes 0.650434783 0.416996047 0.647361647 kegg kegg NA NA no no no no no up Chemical carcinogenesis - receptor activation Aldosterone synthesis and secretion 0.693913043 0.597826087 0.715572716 kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation alpha-Linolenic acid metabolism -0.574782609 0 -0.522779923 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Alzheimer disease 0.51826087 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Amphetamine addiction 0.794782609 0.491106719 0.693436293 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation AMPK signaling pathway 0 0.584980237 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Amyotrophic lateral sclerosis 0.534782609 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Antifolate resistance 0 0.539525692 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Antigen processing and presentation -0.608695652 -0.790513834 -0.502445302 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Apoptosis - multiple species 0 0.43083004 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Bacterial invasion of epithelial cells 0 -0.480237154 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Base excision repair 0 0.41798419 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation beta-Alanine metabolism -0.536521739 0 -0.485971686 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Bifidobacterium 0 0 0.400271524 acetate-producing kegg Genus NA 0.105 no no no no dn no Chemical carcinogenesis - receptor activation Bile secretion 0.607826087 0.47826087 0.503732304 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Biosynthesis of amino acids -0.620869565 -0.586956522 -0.503989704 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Biosynthesis of unsaturated fatty acids 0 -0.424901186 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Blautia -0.462608696 0 0 acetate-producing kegg Genus NA 1.36E-05 no no no up dn dn Chemical carcinogenesis - receptor activation Butanoate metabolism -0.495652174 0 -0.42033462 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Calcium signaling pathway 0.535652174 0.435770751 0.645302445 kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation cAMP signaling pathway 0.666956522 0 0.665894466 yes kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation Carbohydrate digestion and absorption 0 0.418972332 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Carbon metabolism -0.568695652 -0.745059289 -0.60978121 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Cardiac muscle contraction 0.514782609 0 0 kegg kegg NA NA no no no no no up Chemical carcinogenesis - receptor activation Cell adhesion molecules -0.522608696 -0.678853755 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Cell cycle 0 0.457509881 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Cellular senescence -0.433043478 -0.441699605 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation cGMP-PKG signaling pathway 0 -0.43972332 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Chemical carcinogenesis - DNA adducts -0.44 -0.425889328 -0.568082368 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Cholesterol metabolism 0 -0.687747036 0 yes kegg kegg NA NA no no no no no up Chemical carcinogenesis - receptor activation Cholinergic synapse 0.497391304 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Circadian entrainment 0.552173913 0 0.535135135 kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation Circadian rhythm 0.466086957 0.68083004 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Citrate cycle (TCA cycle) 0 0 -0.462805663 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Clostridium -0.422567302 -0.514496764 0 kegg Genus NA 0.925 no no no no no no Chemical carcinogenesis - receptor activation Cocaine addiction 0.595652174 0.785573123 0.675160875 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Complement and coagulation cascades -0.509565217 -0.482213439 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Cortisol synthesis and secretion 0.685217391 0.864624506 0.778378378 kegg kegg NA NA no no no no no up Chemical carcinogenesis - receptor activation Cushing syndrome 0.742608696 0.863636364 0.803603604 kegg kegg NA NA no no no no no up Chemical carcinogenesis - receptor activation Dopaminergic synapse 0.726956522 0 0.717374517 kegg kegg NA NA no no no no up no Chemical carcinogenesis - receptor activation Dorea -0.44 0 0 kegg Genus NA 0.00362 no no no up no dn Chemical carcinogenesis - receptor activation Drug metabolism - cytochrome P450 0 0 -0.525353925 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Drug metabolism - other enzymes -0.593913043 0 -0.474131274 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Endocrine and other factor-regulated calcium reabsorption 0.565217391 0.470355731 0.664092664 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Endocrine resistance 0.807826087 0.882411067 0.867953668 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Endocytosis -0.483478261 -0.650197628 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Epstein-Barr virus infection -0.533913043 -0.734189723 -0.425225225 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation ErbB signaling pathway 0 0.485177866 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Estrogen signaling pathway 0.446086957 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Ether lipid metabolism 0.420869565 0.451581028 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Fanconi anemia pathway 0 0.469367589 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Fat digestion and absorption 0 0 -0.52972973 yes kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation Fatty acid degradation -0.487826087 0 -0.622651223 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Fatty acid elongation -0.456521739 -0.609683794 -0.436293436 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Fatty acid metabolism -0.582608696 0 -0.61003861 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Fc gamma R-mediated phagocytosis -0.415652174 -0.598814229 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Fructose and mannose metabolism -0.452173913 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Galactose metabolism -0.472173913 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Gap junction 0.466086957 0.545454545 0.439382239 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Glucagon signaling pathway 0.691304348 0.501976285 0.561647362 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Glutamatergic synapse 0.424347826 0.432806324 0.434491634 kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation Glycerophospholipid metabolism 0 0.638339921 0 kegg kegg NA NA no no no no no up Chemical carcinogenesis - receptor activation Glycolysis / Gluconeogenesis -0.426956522 -0.490118577 -0.473873874 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Glycosaminoglycan degradation 0 -0.503952569 0 kegg kegg NA NA no no no no no up Chemical carcinogenesis - receptor activation Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.545454545 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Glyoxylate and dicarboxylate metabolism -0.565217391 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation GnRH secretion 0.413913043 0.529644269 0 kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation GnRH signaling pathway 0.657391304 0.742094862 0.693178893 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation "Growth hormone synthesis, secretion and action" 0.693913043 0.764822134 0.807464607 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Hedgehog signaling pathway 0.529565217 0.510869565 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Hepatitis C 0 0 0.427284427 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Herpes simplex virus 1 infection -0.545217391 -0.704545455 -0.44015444 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Histidine metabolism 0 0 -0.403861004 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Homologous recombination 0 0.435770751 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Human cytomegalovirus infection -0.435652174 -0.687747036 0 kegg kegg NA NA no no no no no dn Chemical carcinogenesis - receptor activation Human immunodeficiency virus 1 infection -0.423478261 -0.703557312 -0.442213642 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Human T-cell leukemia virus 1 infection -0.573043478 -0.725296443 -0.408494208 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Huntington disease 0.474782609 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation IL-17 signaling pathway 0 -0.488142292 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Inflammatory mediator regulation of TRP channels 0.611304348 0 0.689317889 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Influenza A 0 -0.568181818 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Inositol phosphate metabolism 0 0.5256917 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Insulin secretion 0.61826087 0.795454545 0.767567568 yes kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation Leishmaniasis -0.582608696 -0.481225296 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Leukocyte transendothelial migration 0 -0.558300395 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Long-term depression 0.583478261 0.437747036 0.645045045 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Long-term potentiation 0.436521739 0 0 kegg kegg NA NA no no no no no up Chemical carcinogenesis - receptor activation Longevity regulating pathway 0 0.471343874 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Longevity regulating pathway - multiple species 0 -0.598814229 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Lysine degradation 0 0.672924901 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Lysosome 0 -0.68972332 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Mannose type O-glycan biosynthesis 0 0.563241107 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Maturity onset diabetes of the young 0 0.448616601 0 kegg kegg NA NA no no no no up no Chemical carcinogenesis - receptor activation Melanogenesis 0.611304348 0 0.696010296 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Metabolism of xenobiotics by cytochrome P450 -0.413043478 0 -0.554697555 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Morphine addiction 0.592173913 0.586956522 0.633976834 kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation mRNA surveillance pathway 0.52173913 0.467391304 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Natural killer cell mediated cytotoxicity -0.497391304 -0.555335968 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Neuroactive ligand-receptor interaction 0 -0.714426877 0 kegg kegg NA NA no no no up up up Chemical carcinogenesis - receptor activation Neutrophil extracellular trap formation -0.51826087 -0.564229249 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Nicotinate and nicotinamide metabolism -0.466086957 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Nicotine addiction 0 0.623517787 0 kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation Non-alcoholic fatty liver disease 0.571304348 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Non-homologous end-joining 0 -0.424901186 -0.403346203 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Notch signaling pathway 0 0.700592885 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Odoribacter 0 -0.57503891 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Chemical carcinogenesis - receptor activation Olfactory transduction 0 -0.501976285 -0.43963964 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Osteoclast differentiation -0.406086957 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Other types of O-glycan biosynthesis 0 0.778656126 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Ovarian steroidogenesis 0.620869565 0.611660079 0.509137709 kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation Oxidative phosphorylation 0.459130435 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation p53 signaling pathway 0 0.556324111 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Pancreatic secretion 0.600869565 0 0.71042471 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Pantothenate and CoA biosynthesis 0 0 -0.491891892 kegg kegg NA NA no no no no no dn Chemical carcinogenesis - receptor activation Paraprevotella -0.416995205 0 0 kegg Genus NA 0.118 no no no no no no Chemical carcinogenesis - receptor activation "Parathyroid hormone synthesis, secretion and action" 0.680869565 0 0.651994852 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Parkinson disease 0.509565217 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Pathogenic Escherichia coli infection 0 -0.668972332 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Pathways in cancer 0.560869565 0 0.52998713 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Pathways of neurodegeneration - multiple diseases 0.503478261 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Pentose phosphate pathway -0.456521739 -0.588932806 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Peroxisome -0.584347826 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Pertussis 0 -0.618577075 0 kegg kegg NA NA no no no no no dn Chemical carcinogenesis - receptor activation Phagosome -0.545217391 -0.690711462 -0.413127413 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Phosphatidylinositol signaling system 0.490434783 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Phospholipase D signaling pathway 0 0 0.500900901 kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation Phototransduction 0 -0.505928854 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Platinum drug resistance 0 0.505928854 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Prevotella 0 0 0.458451614 acetate-producing kegg Genus NA 0.287 no no no no no no Chemical carcinogenesis - receptor activation Primary bile acid biosynthesis 0 -0.4743083 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Prion disease 0.484347826 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Progesterone-mediated oocyte maturation 0 0.5 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Proteasome 0 -0.504940711 -0.572972973 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Protein digestion and absorption -0.526956522 0 0 yes kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation Purine metabolism 0 0.494071146 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Pyrimidine metabolism -0.486086957 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Regulation of actin cytoskeleton 0 -0.4743083 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Regulation of lipolysis in adipocytes 0.688695652 0.641304348 0.655341055 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Relaxin signaling pathway 0.540869565 0 0.654826255 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Renin secretion 0.448695652 0 0.52972973 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Renin-angiotensin system 0 -0.588932806 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Ribosome biogenesis in eukaryotes 0 0.427865613 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation RNA degradation 0.425217391 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Salivary secretion 0 0 0.422908623 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Salmonella infection 0 -0.828063241 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Selenocompound metabolism 0 0.564229249 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Serotonergic synapse 0.585217391 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Signaling pathways regulating pluripotency of stem cells 0.586956522 0.683794466 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Spliceosome 0 0.495059289 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Staphylococcus aureus infection -0.645217391 -0.73715415 0 kegg kegg NA NA no no no up no no Chemical carcinogenesis - receptor activation Steroid biosynthesis 0.433913043 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Synaptic vesicle cycle 0 -0.536561265 0 kegg kegg NA NA no no no no up up Chemical carcinogenesis - receptor activation Taurine and hypotaurine metabolism 0 0.703557312 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Thermogenesis 0.50173913 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Thyroid hormone synthesis 0 0.651185771 0.418275418 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Tight junction 0 -0.4743083 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Toxoplasmosis 0 -0.53458498 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Tryptophan metabolism -0.471304348 0 -0.458172458 kegg kegg NA NA no no no no up no Chemical carcinogenesis - receptor activation Tuberculosis -0.624347826 -0.694664032 -0.403603604 kegg kegg NA NA no no no no no dn Chemical carcinogenesis - receptor activation Type I diabetes mellitus -0.535652174 -0.583003953 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Type II diabetes mellitus 0 0.447628458 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Ubiquitin mediated proteolysis 0.43826087 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Vascular smooth muscle contraction 0.48 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Vasopressin-regulated water reabsorption 0.711304348 0.421936759 0.60952381 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Vitamin digestion and absorption 0.448695652 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Wnt signaling pathway 0.425217391 0 0 kegg kegg NA NA no no no no no no Chemical carcinogenesis - receptor activation Yersinia infection 0 -0.635375494 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway 2-Oxocarboxylic acid metabolism 0 -0.652173913 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway "Alanine, aspartate and glutamate metabolism" 0 0.60770751 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Amino sugar and nucleotide sugar metabolism 0 -0.431818182 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Aminoacyl-tRNA biosynthesis -0.526956522 -0.747035573 -0.548262548 kegg kegg NA NA no no no no no no Chemokine signaling pathway Arachidonic acid metabolism -0.406956522 0 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Arginine and proline metabolism 0 0.706521739 0.433976834 kegg kegg NA NA no no no no up no Chemokine signaling pathway Arginine biosynthesis 0 0.674901186 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Ascorbate and aldarate metabolism 0 -0.514822134 -0.455083655 kegg kegg NA NA no no no no no no Chemokine signaling pathway Basal transcription factors 0 -0.790513834 -0.690862291 kegg kegg NA NA no no no no no no Chemokine signaling pathway Base excision repair -0.513043478 -0.59486166 -0.701930502 kegg kegg NA NA no no no no no no Chemokine signaling pathway Biosynthesis of amino acids 0 0.663043478 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Biosynthesis of cofactors -0.555652174 -0.617588933 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Biosynthesis of unsaturated fatty acids -0.447826087 0 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Butanoate metabolism -0.500869565 -0.651185771 -0.597683398 kegg kegg NA NA no no no no no no Chemokine signaling pathway cAMP signaling pathway 0.433043478 0.5 0 yes kegg kegg NA NA no no no no up up Chemokine signaling pathway cGMP-PKG signaling pathway 0 0.761857708 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Citrate cycle (TCA cycle) -0.58 -0.671936759 -0.5001287 kegg kegg NA NA no no no no no no Chemokine signaling pathway Cysteine and methionine metabolism -0.433913043 -0.565217391 -0.592792793 kegg kegg NA NA no no no no no no Chemokine signaling pathway Cytokine-cytokine receptor interaction 0.700869565 0.509881423 0.46023166 kegg kegg NA NA no no no no no no Chemokine signaling pathway DNA replication -0.606956522 -0.769762846 -0.505276705 kegg kegg NA NA no no no no no no Chemokine signaling pathway Drug metabolism - cytochrome P450 0 -0.646245059 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Drug metabolism - other enzymes 0 -0.526679842 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway EGFR tyrosine kinase inhibitor resistance 0 0 -0.476962677 kegg kegg NA NA no no no no no no Chemokine signaling pathway Ether lipid metabolism 0 -0.735177866 -0.523809524 kegg kegg NA NA no no no no no no Chemokine signaling pathway Fanconi anemia pathway -0.544347826 -0.739130435 -0.655855856 kegg kegg NA NA no no no no no no Chemokine signaling pathway Fatty acid biosynthesis 0 0.650197628 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Folate biosynthesis 0 -0.501976285 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Glutathione metabolism -0.443478261 0 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Glycerophospholipid metabolism 0 0 -0.491634492 kegg kegg NA NA no no no no no up Chemokine signaling pathway "Glycine, serine and threonine metabolism" -0.465217391 -0.462450593 0 kegg kegg NA NA no no no no up no Chemokine signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.463438735 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.427865613 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Glycosaminoglycan degradation 0.495652174 0 0 kegg kegg NA NA no no no no no up Chemokine signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 -0.68972332 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.557312253 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.688735178 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Histidine metabolism -0.436521739 0 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Homologous recombination -0.41826087 -0.542490119 -0.714285714 kegg kegg NA NA no no no no no no Chemokine signaling pathway Inositol phosphate metabolism 0 0 -0.516087516 kegg kegg NA NA no no no no no no Chemokine signaling pathway Lysine degradation 0 -0.522727273 -0.50990991 kegg kegg NA NA no no no no no no Chemokine signaling pathway Mannose type O-glycan biosynthesis 0 0 -0.414671815 kegg kegg NA NA no no no no no no Chemokine signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.605731225 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Mismatch repair -0.493043478 -0.592885375 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway mRNA surveillance pathway 0 -0.717391304 -0.486229086 kegg kegg NA NA no no no no no no Chemokine signaling pathway N-Glycan biosynthesis -0.427826087 -0.732213439 -0.44041184 kegg kegg NA NA no no no no no no Chemokine signaling pathway Nicotinate and nicotinamide metabolism 0 0.692687747 0.412612613 kegg kegg NA NA no no no no no no Chemokine signaling pathway Nitrogen metabolism 0 0.719367589 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Non-homologous end-joining 0 0 -0.419047619 kegg kegg NA NA no no no no no no Chemokine signaling pathway Nucleotide excision repair -0.627826087 -0.734189723 -0.637065637 kegg kegg NA NA no no no no no no Chemokine signaling pathway One carbon pool by folate -0.663478261 -0.739130435 -0.603088803 kegg kegg NA NA no no no no no no Chemokine signaling pathway Other types of O-glycan biosynthesis 0 -0.506916996 -0.615444015 kegg kegg NA NA no no no no no no Chemokine signaling pathway Oxidative phosphorylation 0 -0.429841897 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Pantothenate and CoA biosynthesis 0 0.542490119 0 kegg kegg NA NA no no no no no dn Chemokine signaling pathway Pentose and glucuronate interconversions 0 -0.777667984 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Pentose phosphate pathway 0 0.705533597 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Phenylalanine metabolism 0 -0.491106719 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Platinum drug resistance 0 0 -0.610553411 kegg kegg NA NA no no no no no no Chemokine signaling pathway Porphyrin and chlorophyll metabolism -0.440869565 -0.434782609 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway PPAR signaling pathway 0 0.584980237 0.569111969 kegg kegg NA NA no no no no no no Chemokine signaling pathway Primary bile acid biosynthesis -0.626086957 0 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Propanoate metabolism -0.451304348 -0.496047431 -0.607722008 kegg kegg NA NA no no no no no no Chemokine signaling pathway Proteasome 0 -0.56027668 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Protein export 0 -0.62944664 -0.452509653 kegg kegg NA NA no no no no no no Chemokine signaling pathway Purine metabolism -0.425217391 -0.470355731 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Pyrimidine metabolism -0.532173913 -0.58201581 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Pyruvate metabolism -0.593913043 -0.625494071 -0.644015444 kegg kegg NA NA no no no no no no Chemokine signaling pathway Rap1 signaling pathway 0 0 0.572200772 kegg kegg NA NA no no no no no no Chemokine signaling pathway Ras signaling pathway 0 -0.449604743 0 yes kegg kegg NA NA no no no no up up Chemokine signaling pathway Retinol metabolism 0 -0.479249012 -0.507593308 kegg kegg NA NA no no no no no no Chemokine signaling pathway Ribosome biogenesis in eukaryotes -0.493043478 -0.804347826 -0.642985843 kegg kegg NA NA no no no no no no Chemokine signaling pathway RNA degradation 0 -0.706521739 -0.4998713 kegg kegg NA NA no no no no no no Chemokine signaling pathway RNA polymerase 0 -0.838932806 -0.60952381 kegg kegg NA NA no no no no no no Chemokine signaling pathway RNA transport 0 0 -0.438867439 kegg kegg NA NA no no no no no no Chemokine signaling pathway Selenocompound metabolism -0.43826087 -0.549407115 -0.676190476 kegg kegg NA NA no no no no no no Chemokine signaling pathway Spliceosome 0 -0.433794466 -0.620592021 kegg kegg NA NA no no no no no no Chemokine signaling pathway Starch and sucrose metabolism 0 0.466403162 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Steroid biosynthesis 0 -0.617588933 -0.474131274 kegg kegg NA NA no no no no no no Chemokine signaling pathway Steroid hormone biosynthesis -0.444347826 -0.524703557 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Sulfur metabolism -0.499130435 0 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Synthesis and degradation of ketone bodies -0.605217391 -0.727272727 -0.558043758 kegg kegg NA NA no no no no no no Chemokine signaling pathway Terpenoid backbone biosynthesis 0 -0.697628458 -0.442985843 kegg kegg NA NA no no no no no no Chemokine signaling pathway Thiamine metabolism 0 -0.46541502 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Tryptophan metabolism -0.560869565 -0.502964427 -0.555469755 kegg kegg NA NA no no no no up no Chemokine signaling pathway Tyrosine metabolism -0.443478261 -0.564229249 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.656521739 -0.650197628 -0.522779923 kegg kegg NA NA no no no no no no Chemokine signaling pathway "Valine, leucine and isoleucine degradation" -0.673913043 -0.75 -0.58970399 kegg kegg NA NA no no no no no no Chemokine signaling pathway Various types of N-glycan biosynthesis 0 -0.674901186 0 kegg kegg NA NA no no no no no no Chemokine signaling pathway Viral protein interaction with cytokine and cytokine receptor 0.774782609 0.718379447 0.68005148 kegg kegg NA NA no no no no no no Cholesterol metabolism ABC transporters 0 -0.549407115 0 yes kegg kegg NA NA no no up no up up Cholesterol metabolism Adipocytokine signaling pathway 0.539130435 0 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Aldosterone synthesis and secretion 0 -0.57312253 -0.473873874 yes kegg kegg NA NA no no up no up up Cholesterol metabolism Aminoacyl-tRNA biosynthesis -0.517391304 0 -0.420592021 yes kegg kegg NA NA no no up no no no Cholesterol metabolism AMPK signaling pathway 0 -0.499011858 -0.420849421 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Antifolate resistance -0.557391304 -0.567193676 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Antigen processing and presentation 0.506086957 0.593873518 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Apoptosis 0 0.578063241 0.420592021 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Apoptosis - multiple species -0.466086957 -0.541501976 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Arginine and proline metabolism 0 0 0.463577864 yes kegg kegg NA NA no no up no up no Cholesterol metabolism Axon guidance 0 0.415019763 0 yes kegg kegg NA NA no no up no up up Cholesterol metabolism B cell receptor signaling pathway 0 0.425889328 0.607979408 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Basal transcription factors 0 -0.546442688 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Base excision repair -0.446956522 -0.652173913 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Bile secretion 0 0 -0.422908623 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Biosynthesis of amino acids 0 0.606719368 0.415958816 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Biosynthesis of cofactors 0 -0.666007905 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism C-type lectin receptor signaling pathway 0 0.41798419 0.482625483 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Carbon metabolism 0 0.664031621 0.442985843 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Cell adhesion molecules 0 0.729249012 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Cell cycle -0.507826087 -0.650197628 -0.40978121 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Cellular senescence 0 0.553359684 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism cGMP-PKG signaling pathway 0 0.545454545 0.707593308 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Circadian entrainment 0 0 -0.422651223 yes kegg kegg NA NA no no up no up up Cholesterol metabolism Circadian rhythm 0 -0.565217391 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Complement and coagulation cascades 0 0.458498024 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Cortisol synthesis and secretion 0 -0.608695652 -0.404890605 yes kegg kegg NA NA no no up no no up Cholesterol metabolism Cushing syndrome 0 -0.674901186 0 yes kegg kegg NA NA no no up no no up Cholesterol metabolism Cysteine and methionine metabolism 0 0 -0.435006435 yes kegg kegg NA NA no no up no no no Cholesterol metabolism DNA replication -0.448695652 0 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Dopaminergic synapse 0 -0.437747036 0 yes kegg kegg NA NA no no up no up no Cholesterol metabolism Drug metabolism - other enzymes 0 0 0.404890605 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Endocrine and other factor-regulated calcium reabsorption 0 -0.477272727 -0.559330759 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Endocrine resistance 0 -0.650197628 -0.473101673 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Endocytosis 0 0.646245059 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Estrogen signaling pathway -0.512173913 0 -0.653024453 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Ether lipid metabolism 0 -0.564229249 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Fanconi anemia pathway -0.592173913 -0.595849802 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Fat digestion and absorption 0 0 0.647361647 yes yes kegg kegg NA NA no no up no up up Cholesterol metabolism Fc epsilon RI signaling pathway 0 0 0.583268983 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Fc gamma R-mediated phagocytosis 0 0.448616601 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism FoxO signaling pathway -0.549565217 0 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Fructose and mannose metabolism 0 0 0.404118404 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Gap junction 0 0 -0.422651223 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Glucagon signaling pathway 0 -0.56027668 -0.476962677 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Glycerophospholipid metabolism 0 -0.558300395 0 yes kegg kegg NA NA no no up no no up Cholesterol metabolism "Glycine, serine and threonine metabolism" 0 -0.657114625 0 yes kegg kegg NA NA no no up no up no Cholesterol metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0 0.43989704 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Glycosaminoglycan degradation 0.69826087 0.588932806 0.527927928 yes kegg kegg NA NA no no up no no up Cholesterol metabolism Glycosphingolipid biosynthesis - globo and isoglobo series 0.506956522 0 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.640869565 -0.650197628 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Glyoxylate and dicarboxylate metabolism 0 0 0.43037323 yes kegg kegg NA NA no no up no no no Cholesterol metabolism GnRH signaling pathway 0 -0.513833992 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism "Growth hormone synthesis, secretion and action" 0 -0.489130435 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Hedgehog signaling pathway 0 -0.570158103 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Hippo signaling pathway - multiple species 0 0 0.622908623 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Homologous recombination -0.633043478 -0.550395257 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism IL-17 signaling pathway 0 0.62944664 0.612355212 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Inflammatory mediator regulation of TRP channels 0 -0.4743083 -0.65971686 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Inositol phosphate metabolism -0.596521739 -0.460474308 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Insulin secretion 0 -0.603754941 0 yes yes kegg kegg NA NA no no up no up up Cholesterol metabolism Intestinal immune network for IgA production 0 0.504940711 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism JAK-STAT signaling pathway -0.583478261 0 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Leukocyte transendothelial migration 0 0.564229249 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Long-term depression 0 0 -0.406177606 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Longevity regulating pathway 0 -0.509881423 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Longevity regulating pathway - multiple species -0.48173913 0 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Lysine degradation 0 -0.509881423 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Lysosome 0.570434783 0.735177866 0.721750322 yes kegg kegg NA NA no no up no no no Cholesterol metabolism MAPK signaling pathway -0.462608696 0 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Melanogenesis 0 -0.423913043 -0.569111969 yes kegg kegg NA NA no no up no no no Cholesterol metabolism N-Glycan biosynthesis -0.412173913 0 -0.431402831 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Natural killer cell mediated cytotoxicity 0 0.614624506 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Neuroactive ligand-receptor interaction 0 0.517786561 0.533848134 yes kegg kegg NA NA no no up up up up Cholesterol metabolism Neurotrophin signaling pathway 0 0.440711462 0.498069498 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Neutrophil extracellular trap formation 0 0.460474308 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Nicotinate and nicotinamide metabolism 0 0 0.594079794 yes kegg kegg NA NA no no up no no no Cholesterol metabolism NOD-like receptor signaling pathway 0 0.416007905 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Nucleotide excision repair -0.468695652 -0.510869565 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Olfactory transduction 0 0 0.564221364 yes kegg kegg NA NA no no up no no no Cholesterol metabolism One carbon pool by folate -0.693043478 -0.566205534 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Osteoclast differentiation 0 0.467391304 0.552380952 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Other types of O-glycan biosynthesis 0 -0.722332016 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Ovarian steroidogenesis 0 -0.529644269 -0.463835264 yes kegg kegg NA NA no no up no up up Cholesterol metabolism p53 signaling pathway 0 -0.681818182 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Pancreatic secretion 0 0 -0.46023166 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Pantothenate and CoA biosynthesis 0 0 0.527413127 yes kegg kegg NA NA no no up no no dn Cholesterol metabolism Pentose phosphate pathway 0 0.583992095 0.534877735 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Phagosome 0 0.721343874 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Phosphatidylinositol signaling system 0 -0.658102767 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Platinum drug resistance -0.54173913 -0.583003953 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Porphyrin and chlorophyll metabolism 0 -0.510869565 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism PPAR signaling pathway 0.406086957 0.556324111 0.512226512 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Progesterone-mediated oocyte maturation 0 -0.503952569 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Protein processing in endoplasmic reticulum 0 0 -0.465122265 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Purine metabolism 0 -0.656126482 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Pyrimidine metabolism 0 -0.495059289 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Pyruvate metabolism -0.454782609 0 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Regulation of lipolysis in adipocytes 0 -0.536561265 -0.555727156 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Renin secretion 0 0 -0.560875161 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Renin-angiotensin system 0 0.591897233 0.553925354 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Retinol metabolism 0 -0.41798419 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Ribosome biogenesis in eukaryotes -0.544347826 -0.56916996 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism RNA polymerase 0 -0.539525692 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Selenocompound metabolism 0 -0.593873518 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Sphingolipid metabolism 0.653043478 0 0.593307593 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Sphingolipid signaling pathway 0 0.542490119 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Spliceosome 0 -0.537549407 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Starch and sucrose metabolism 0 0 0.591505792 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Synaptic vesicle cycle 0 0.485177866 0.62007722 yes kegg kegg NA NA no no up no up up Cholesterol metabolism Synthesis and degradation of ketone bodies -0.533913043 -0.462450593 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Taste transduction -0.529565217 -0.555335968 0 yes kegg kegg NA NA no no up no no up Cholesterol metabolism Taurine and hypotaurine metabolism 0 -0.438735178 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Th1 and Th2 cell differentiation 0 0.538537549 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Th17 cell differentiation 0 0.527667984 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Thyroid hormone synthesis 0 -0.484189723 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Toll-like receptor signaling pathway 0 0.442687747 0.490862291 yes yes kegg kegg NA NA no no up no no no Cholesterol metabolism Type I diabetes mellitus 0 0.701581028 0 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Vasopressin-regulated water reabsorption 0 -0.433794466 -0.536422136 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Vitamin digestion and absorption 0 0 0.407722008 yes kegg kegg NA NA no no up no no no Cholesterol metabolism Wnt signaling pathway 0 -0.432806324 0 yes kegg kegg NA NA no no up no no no Choline metabolism in cancer 2-Oxocarboxylic acid metabolism -0.624347826 -0.419960474 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer ABC transporters 0 0.650197628 0 kegg kegg NA NA no no no no up up Choline metabolism in cancer Acute myeloid leukemia 0.533913043 0.627470356 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Adherens junction -0.453043478 -0.586956522 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Adipocytokine signaling pathway 0 0.513833992 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Adrenergic signaling in cardiomyocytes 0.472173913 0 0 kegg kegg NA NA no no no no no up Choline metabolism in cancer African trypanosomiasis 0.485217391 0.459486166 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer AGE-RAGE signaling pathway in diabetic complications 0 0.584980237 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer "Alanine, aspartate and glutamate metabolism" 0 0.498023715 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Alcoholism 0 0 -0.443758044 kegg kegg NA NA no no no no no no Choline metabolism in cancer Aldosterone-regulated sodium reabsorption 0.764347826 0 0.468468468 kegg kegg NA NA no no no no no no Choline metabolism in cancer alpha-Linolenic acid metabolism -0.546956522 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Alzheimer disease 0.449565217 -0.484189723 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Amino sugar and nucleotide sugar metabolism -0.599130435 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Aminoacyl-tRNA biosynthesis -0.413043478 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Amoebiasis 0 0.481225296 -0.424453024 kegg kegg NA NA no no no no no no Choline metabolism in cancer Amyotrophic lateral sclerosis 0 -0.450592885 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Antifolate resistance 0 0 0.466924067 kegg kegg NA NA no no no no no no Choline metabolism in cancer Antigen processing and presentation 0 -0.585968379 -0.526126126 kegg kegg NA NA no no no no no no Choline metabolism in cancer Apelin signaling pathway 0 -0.660079051 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Apoptosis 0 0.45256917 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Apoptosis - multiple species 0 0.590909091 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Arachidonic acid metabolism -0.580869565 0 -0.473101673 kegg kegg NA NA no no no no no no Choline metabolism in cancer Arginine biosynthesis 0 0.423913043 -0.482368082 kegg kegg NA NA no no no no no no Choline metabolism in cancer Ascorbate and aldarate metabolism -0.451304348 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Autophagy - animal 0.665217391 0.735177866 0.453796654 kegg kegg NA NA no no no no no no Choline metabolism in cancer Autophagy - other 0.599130435 0.513833992 0.607464607 kegg kegg NA NA no no no no no no Choline metabolism in cancer Axon guidance 0.482608696 0 0 kegg kegg NA NA no no no no up up Choline metabolism in cancer B cell receptor signaling pathway 0.419130435 0.527667984 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Bacterial invasion of epithelial cells -0.58 -0.647233202 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Bacteroides 0 -0.45256917 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Choline metabolism in cancer Basal cell carcinoma 0.415652174 0 0.65997426 kegg kegg NA NA no no no no no no Choline metabolism in cancer Basal transcription factors 0 0 0.400772201 kegg kegg NA NA no no no no no no Choline metabolism in cancer beta-Alanine metabolism -0.769565217 -0.622529644 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Bile secretion 0 0 -0.454568855 kegg kegg NA NA no no no no no no Choline metabolism in cancer Biosynthesis of amino acids -0.590434783 0 -0.574517375 kegg kegg NA NA no no no no no no Choline metabolism in cancer Biosynthesis of cofactors -0.506956522 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Biosynthesis of unsaturated fatty acids -0.590434783 -0.53458498 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Bladder cancer 0 0.583992095 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Breast cancer 0.910434783 0.920948617 0.851737452 kegg kegg NA NA no no no no no no Choline metabolism in cancer Butanoate metabolism -0.710434783 -0.604743083 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer C-type lectin receptor signaling pathway 0.684347826 0.511857708 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Calcium signaling pathway 0.546086957 0 0 kegg kegg NA NA no no no no up up Choline metabolism in cancer cAMP signaling pathway 0.715652174 0.42687747 0 yes kegg kegg NA NA no no no no up up Choline metabolism in cancer Carbohydrate digestion and absorption 0.792173913 0.770750988 0.719433719 kegg kegg NA NA no no no no no no Choline metabolism in cancer Carbon metabolism -0.737391304 -0.523715415 -0.455855856 kegg kegg NA NA no no no no no no Choline metabolism in cancer Cell cycle 0 0 0.51994852 kegg kegg NA NA no no no no no no Choline metabolism in cancer cGMP-PKG signaling pathway 0.420869565 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Chagas disease 0.686956522 0.659090909 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Chemical carcinogenesis - DNA adducts -0.562608696 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Chemical carcinogenesis - receptor activation 0.571304348 0.533596838 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Cholinergic synapse 0.694782609 0 0.789189189 kegg kegg NA NA no no no no no no Choline metabolism in cancer Chronic myeloid leukemia 0.68173913 0.617588933 0.409266409 kegg kegg NA NA no no no no no no Choline metabolism in cancer Circadian rhythm 0.724347826 0 0.683397683 kegg kegg NA NA no no no no no no Choline metabolism in cancer Citrate cycle (TCA cycle) -0.625217391 -0.68972332 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Clostridium 0 -0.628602977 0 kegg Genus NA 0.925 no no no no no no Choline metabolism in cancer Collecting duct acid secretion 0 0 -0.409009009 kegg kegg NA NA no no no no no no Choline metabolism in cancer Collinsella 0 0 -0.441559892 kegg Genus NA 0.128 no no no no no no Choline metabolism in cancer Colorectal cancer 0.772173913 0.528656126 0.911196911 kegg kegg NA NA no no no no no no Choline metabolism in cancer Complement and coagulation cascades -0.507826087 0 -0.44993565 kegg kegg NA NA no no no no no no Choline metabolism in cancer Coronavirus disease - COVID-19 0 -0.590909091 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Cysteine and methionine metabolism 0 -0.687747036 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer DNA replication 0 -0.457509881 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Dopaminergic synapse 0.437391304 0 0 kegg kegg NA NA no no no no up no Choline metabolism in cancer Drug metabolism - cytochrome P450 -0.532173913 -0.705533597 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Drug metabolism - other enzymes -0.823478261 -0.77173913 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer EGFR tyrosine kinase inhibitor resistance 0 -0.510869565 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Endocrine resistance 0.553043478 0.472332016 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Endometrial cancer 0.74173913 0.738142292 0.688288288 kegg kegg NA NA no no no no no no Choline metabolism in cancer Epstein-Barr virus infection 0 -0.447628458 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer ErbB signaling pathway 0.827826087 0.800395257 0.838352638 kegg kegg NA NA no no no no no no Choline metabolism in cancer Ether lipid metabolism 0 0 0.472072072 kegg kegg NA NA no no no no no no Choline metabolism in cancer Fatty acid biosynthesis 0 0.558300395 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Fatty acid elongation -0.764347826 -0.686758893 -0.411840412 kegg kegg NA NA no no no no no no Choline metabolism in cancer Fatty acid metabolism -0.426956522 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Fc epsilon RI signaling pathway 0.603478261 0.602766798 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Fc gamma R-mediated phagocytosis 0 0 -0.506821107 kegg kegg NA NA no no no no no no Choline metabolism in cancer Ferroptosis 0 0 -0.493951094 kegg kegg NA NA no no no no no no Choline metabolism in cancer Focal adhesion -0.445217391 -0.68972332 0 kegg kegg NA NA no no no no up up Choline metabolism in cancer FoxO signaling pathway 0 0.75 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Fructose and mannose metabolism -0.530434783 0.608695652 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Galactose metabolism -0.549565217 0.533596838 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Gastric acid secretion -0.412173913 -0.566205534 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Gastric cancer 0.602608696 0.691699605 0.787387387 kegg kegg NA NA no no no no no no Choline metabolism in cancer Glioma 0.697391304 0 0.705276705 kegg kegg NA NA no no no no no no Choline metabolism in cancer Glutamatergic synapse 0 0.498023715 -0.440926641 kegg kegg NA NA no no no no up up Choline metabolism in cancer Glutathione metabolism -0.433913043 -0.490118577 -0.476962677 kegg kegg NA NA no no no no no no Choline metabolism in cancer Glycerolipid metabolism 0 0.736166008 0.677992278 kegg kegg NA NA no no no no no up Choline metabolism in cancer Glycerophospholipid metabolism 0.44 0.672924901 0.697039897 kegg kegg NA NA no no no no no up Choline metabolism in cancer Glycolysis / Gluconeogenesis -0.73826087 -0.773715415 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.828063241 0.490862291 kegg kegg NA NA no no no no no no Choline metabolism in cancer Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.567826087 0 0.596911197 kegg kegg NA NA no no no no no no Choline metabolism in cancer Glycosaminoglycan biosynthesis - keratan sulfate 0.416521739 0 0.547747748 kegg kegg NA NA no no no no no no Choline metabolism in cancer Glycosaminoglycan degradation 0 0 0.415444015 kegg kegg NA NA no no no no no up Choline metabolism in cancer Glycosphingolipid biosynthesis - lacto and neolacto series 0.523478261 0.497035573 0.491634492 kegg kegg NA NA no no no no no no Choline metabolism in cancer Glyoxylate and dicarboxylate metabolism 0 0 -0.462290862 kegg kegg NA NA no no no no no no Choline metabolism in cancer GnRH secretion 0.875652174 0.838932806 0.866666667 kegg kegg NA NA no no no no up up Choline metabolism in cancer "Growth hormone synthesis, secretion and action" 0.78 0.809288538 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Hedgehog signaling pathway 0.519130435 0 0.759073359 kegg kegg NA NA no no no no no no Choline metabolism in cancer Hematopoietic cell lineage 0 -0.539525692 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Hepatitis B 0.64 0.706521739 0.466409266 kegg kegg NA NA no no no no no no Choline metabolism in cancer Hepatitis C 0.5 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Herpes simplex virus 1 infection 0 -0.420948617 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer HIF-1 signaling pathway 0 -0.632411067 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Hippo signaling pathway -0.46 -0.583992095 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Hippo signaling pathway - multiple species 0 0 0.462548263 kegg kegg NA NA no no no no no no Choline metabolism in cancer Histidine metabolism -0.514782609 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Human cytomegalovirus infection 0 0 -0.427541828 kegg kegg NA NA no no no no no dn Choline metabolism in cancer Human immunodeficiency virus 1 infection 0 0 -0.419047619 kegg kegg NA NA no no no no no no Choline metabolism in cancer Human T-cell leukemia virus 1 infection 0 -0.485177866 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Huntington disease 0.431304348 -0.457509881 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Inositol phosphate metabolism 0 0.684782609 0.710939511 kegg kegg NA NA no no no no no no Choline metabolism in cancer Insulin resistance 0.785217391 0.78458498 0.530759331 kegg kegg NA NA no no no no no no Choline metabolism in cancer Insulin signaling pathway 0 -0.631422925 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer JAK-STAT signaling pathway 0 0.815217391 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Kaposi sarcoma-associated herpesvirus infection 0 0 -0.473616474 kegg kegg NA NA no no no no no dn Choline metabolism in cancer Legionellosis 0 0 -0.477734878 kegg kegg NA NA no no no no no no Choline metabolism in cancer Leishmaniasis -0.506086957 -0.504940711 -0.504247104 kegg kegg NA NA no no no no no no Choline metabolism in cancer Leukocyte transendothelial migration 0 -0.481225296 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Linoleic acid metabolism -0.555652174 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Long-term potentiation 0.426086957 -0.608695652 0.506821107 kegg kegg NA NA no no no no no up Choline metabolism in cancer Longevity regulating pathway 0.545217391 0.4743083 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Lysine degradation 0 0.41798419 0.744144144 kegg kegg NA NA no no no no no no Choline metabolism in cancer Malaria 0 0 -0.527927928 kegg kegg NA NA no no no no no no Choline metabolism in cancer Mannose type O-glycan biosynthesis 0.543478261 0.466403162 0.73951094 kegg kegg NA NA no no no no no no Choline metabolism in cancer MAPK signaling pathway 0 0.419960474 0.764221364 kegg kegg NA NA no no no no no no Choline metabolism in cancer Maturity onset diabetes of the young 0 0 0.480823681 kegg kegg NA NA no no no no up no Choline metabolism in cancer Melanoma 0.852173913 0.741106719 0.66975547 kegg kegg NA NA no no no no no no Choline metabolism in cancer Metabolism of xenobiotics by cytochrome P450 -0.645217391 -0.73715415 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer MicroRNAs in cancer 0.445217391 0.700592885 0.733848134 kegg kegg NA NA no no no no no no Choline metabolism in cancer Mineral absorption 0 0 -0.474903475 kegg kegg NA NA no no no no no no Choline metabolism in cancer Mismatch repair -0.475652174 -0.515810277 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Mitophagy - animal 0 0 -0.431660232 kegg kegg NA NA no no no no no no Choline metabolism in cancer mRNA surveillance pathway 0.614782609 0 0.655598456 kegg kegg NA NA no no no no no no Choline metabolism in cancer mTOR signaling pathway 0 -0.53458498 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer N-Glycan biosynthesis 0 0 0.406692407 kegg kegg NA NA no no no no no no Choline metabolism in cancer Necroptosis 0 0 -0.528700129 kegg kegg NA NA no no no no no no Choline metabolism in cancer Neurotrophin signaling pathway 0.679130435 0.428853755 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Neutrophil extracellular trap formation 0 0 -0.519433719 kegg kegg NA NA no no no no no no Choline metabolism in cancer NF-kappa B signaling pathway 0 0.705533597 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Nicotinate and nicotinamide metabolism 0 0.511857708 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Nicotine addiction 0 0.550395257 0 kegg kegg NA NA no no no no up up Choline metabolism in cancer NOD-like receptor signaling pathway 0 0.447628458 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Non-alcoholic fatty liver disease 0.497391304 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Non-homologous end-joining -0.714782609 -0.672924901 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Non-small cell lung cancer 0.84173913 0.862648221 0.851222651 kegg kegg NA NA no no no no no no Choline metabolism in cancer Notch signaling pathway 0.546956522 0.782608696 0.763706564 kegg kegg NA NA no no no no no no Choline metabolism in cancer Oocyte meiosis 0 -0.720355731 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Other glycan degradation 0 0.509881423 0.531531532 kegg kegg NA NA no no no no no no Choline metabolism in cancer Other types of O-glycan biosynthesis 0.463478261 0.479249012 0.698841699 kegg kegg NA NA no no no no no no Choline metabolism in cancer Ovarian steroidogenesis 0 0 -0.421106821 kegg kegg NA NA no no no no up up Choline metabolism in cancer Oxidative phosphorylation 0 -0.469367589 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Oxytocin signaling pathway -0.424347826 -0.428853755 -0.439124839 kegg kegg NA NA no no no no no no Choline metabolism in cancer p53 signaling pathway 0.559130435 0.561264822 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Pancreatic cancer 0.48 0 0.524066924 kegg kegg NA NA no no no no no no Choline metabolism in cancer Paraprevotella -0.505831203 0 0 kegg Genus NA 0.118 no no no no no no Choline metabolism in cancer "Parathyroid hormone synthesis, secretion and action" 0.489565217 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Parkinson disease 0 -0.467391304 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Pathways in cancer 0.706956522 0.776679842 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Pathways of neurodegeneration - multiple diseases 0 -0.45256917 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Pentose and glucuronate interconversions -0.663478261 -0.581027668 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Pentose phosphate pathway 0 0 -0.423166023 kegg kegg NA NA no no no no no no Choline metabolism in cancer Peroxisome 0 0 -0.529472329 kegg kegg NA NA no no no no no no Choline metabolism in cancer Phagosome 0 0 -0.43989704 kegg kegg NA NA no no no no no no Choline metabolism in cancer Phenylalanine metabolism -0.716521739 -0.545454545 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Phosphatidylinositol signaling system 0.631304348 0 0.791248391 kegg kegg NA NA no no no no no no Choline metabolism in cancer Phospholipase D signaling pathway 0 0.746047431 0 kegg kegg NA NA no no no no up up Choline metabolism in cancer Phototransduction 0 -0.846837945 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Platelet activation -0.43826087 -0.518774704 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Platinum drug resistance 0 0.552371542 0.411583012 kegg kegg NA NA no no no no no no Choline metabolism in cancer Prevotella 0 0.539966901 0 acetate-producing kegg Genus NA 0.287 no no no no no no Choline metabolism in cancer Primary bile acid biosynthesis -0.565217391 -0.666996047 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Prion disease 0 -0.584980237 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Progesterone-mediated oocyte maturation 0.520869565 0.531620553 0.654311454 kegg kegg NA NA no no no no no no Choline metabolism in cancer Prolactin signaling pathway 0.716521739 0.712450593 0.455855856 kegg kegg NA NA no no no no no no Choline metabolism in cancer Propanoate metabolism -0.454782609 -0.692687747 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Prostate cancer 0.759130435 0.585968379 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Proteasome 0 -0.781620553 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Protein export 0 -0.681818182 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Proteoglycans in cancer 0 -0.572134387 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Proximal tubule bicarbonate reclamation 0 -0.565217391 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Pyrimidine metabolism -0.63826087 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Pyruvate metabolism -0.445217391 -0.670948617 -0.400514801 kegg kegg NA NA no no no no no no Choline metabolism in cancer Ras signaling pathway 0 -0.448616601 0.597940798 yes kegg kegg NA NA no no no no up up Choline metabolism in cancer Regulation of actin cytoskeleton -0.649565217 -0.754940711 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Relaxin signaling pathway 0.702608696 0.593873518 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Renal cell carcinoma 0.552173913 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Renin secretion 0 -0.48715415 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Retinol metabolism -0.568695652 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Retrograde endocannabinoid signaling 0 -0.602766798 0 kegg kegg NA NA no no no no no up Choline metabolism in cancer Ribosome 0 -0.58201581 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Ribosome biogenesis in eukaryotes 0 0 0.434749035 kegg kegg NA NA no no no no no no Choline metabolism in cancer RIG-I-like receptor signaling pathway 0.493913043 0.634387352 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer RNA degradation 0.567826087 0 0.612355212 kegg kegg NA NA no no no no no no Choline metabolism in cancer RNA transport 0 -0.502964427 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Salivary secretion 0 0 -0.438867439 kegg kegg NA NA no no no no no no Choline metabolism in cancer Salmonella infection -0.446086957 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Selenocompound metabolism 0 0 0.442985843 kegg kegg NA NA no no no no no no Choline metabolism in cancer Shigellosis 0 -0.427865613 -0.544658945 kegg kegg NA NA no no no no no no Choline metabolism in cancer Signaling pathways regulating pluripotency of stem cells 0.812173913 0.636363636 0.77966538 kegg kegg NA NA no no no no no no Choline metabolism in cancer Small cell lung cancer 0.557391304 0.696640316 0 kegg kegg NA NA no no no no no up Choline metabolism in cancer SNARE interactions in vesicular transport 0 0.507905138 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Sphingolipid signaling pathway 0.682608696 0 0.585070785 kegg kegg NA NA no no no no no no Choline metabolism in cancer Spinocerebellar ataxia 0.675652174 0 0.497297297 kegg kegg NA NA no no no no no no Choline metabolism in cancer Spliceosome 0 0 0.468725869 kegg kegg NA NA no no no no no no Choline metabolism in cancer Staphylococcus aureus infection -0.512173913 0 -0.499356499 kegg kegg NA NA no no no up no no Choline metabolism in cancer Starch and sucrose metabolism 0 0.483201581 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Steroid biosynthesis 0 -0.471343874 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Steroid hormone biosynthesis -0.634782609 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Sulfur metabolism -0.580869565 -0.523715415 -0.441184041 kegg kegg NA NA no no no no no no Choline metabolism in cancer T cell receptor signaling pathway 0 0.469367589 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Taste transduction 0 0 0.669498069 kegg kegg NA NA no no no no no up Choline metabolism in cancer Taurine and hypotaurine metabolism 0.5 0.804347826 0.476447876 kegg kegg NA NA no no no no no no Choline metabolism in cancer Terpenoid backbone biosynthesis 0 0 0.421364221 kegg kegg NA NA no no no no no no Choline metabolism in cancer TGF-beta signaling pathway 0 -0.648221344 0.515057915 kegg kegg NA NA no no no no no no Choline metabolism in cancer Thermogenesis 0 -0.492094862 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Thiamine metabolism 0 -0.564229249 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Thyroid cancer 0 -0.45256917 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Tight junction -0.588695652 -0.734189723 -0.465122265 kegg kegg NA NA no no no no no no Choline metabolism in cancer TNF signaling pathway 0.77826087 0.666007905 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Toll-like receptor signaling pathway 0.610434783 0.502964427 0 yes kegg kegg NA NA no no no no no no Choline metabolism in cancer Transcriptional misregulation in cancer 0.512173913 0.7243083 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Tryptophan metabolism -0.713913043 -0.652173913 0 kegg kegg NA NA no no no no up no Choline metabolism in cancer Type II diabetes mellitus 0.855652174 0.834980237 0.598970399 kegg kegg NA NA no no no no no no Choline metabolism in cancer Tyrosine metabolism -0.672173913 -0.528656126 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Ubiquinone and other terpenoid-quinone biosynthesis -0.591304348 0 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Ubiquitin mediated proteolysis 0 0 -0.421879022 kegg kegg NA NA no no no no no no Choline metabolism in cancer "Valine, leucine and isoleucine degradation" -0.57826087 -0.502964427 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Vascular smooth muscle contraction 0 -0.546442688 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer VEGF signaling pathway 0.780869565 0.558300395 0.73024453 kegg kegg NA NA no no no no no no Choline metabolism in cancer Vibrio cholerae infection 0 -0.5 0 kegg kegg NA NA no no no no no no Choline metabolism in cancer Viral protein interaction with cytokine and cytokine receptor 0 0 -0.511711712 kegg kegg NA NA no no no no no no Choline metabolism in cancer Vitamin digestion and absorption 0.514782609 0 0.476447876 kegg kegg NA NA no no no no no no Choline metabolism in cancer Wnt signaling pathway 0 0 0.750579151 kegg kegg NA NA no no no no no no Choline+blood 14:0/18:2-PC+blood -0.461654135 0 0 serum_choline serum_phospholipids 0.0395 0.102 no up no no up no Choline+blood 14:0/20:4-PC+blood -0.45112782 0 0 serum_choline serum_phospholipids 0.0395 0.486 no up no no no no Choline+blood 15-HETE+blood 0 0 -0.433622152 serum_choline serum_ARA 0.0395 0.819 no up no no no no Choline+blood 16:0-LPC+blood 0 0.544117647 0 serum_choline serum_phospholipids 0.0395 0.00456 no up no up up no Choline+blood 16:0/18:0-PS+blood 0 -0.585784314 0 serum_choline serum_phospholipids 0.0395 0.377 no up no no no no Choline+blood 16:0/20:5-PC+blood -0.527819549 0 0 serum_choline serum_phospholipids 0.0395 0.628 no up no no no no Choline+blood 16:0/22:6-PE+blood 0 -0.529411765 0 serum_choline serum_phospholipids 0.0395 0.000934 no up no up up no Choline+blood 18:0/18:0-PS+blood 0 -0.620098039 0 serum_choline serum_phospholipids 0.0395 0.00617 no up no no up no Choline+blood 18:0/22:6-PC+blood 0 -0.509803922 0 serum_choline serum_phospholipids 0.0395 0.0775 no up no no no up Choline+blood 18:0/22:6-PE+blood 0 -0.588235294 0 serum_choline serum_phospholipids 0.0395 0.00022 no up no up up no Choline+blood 18:0/22:6-PI+blood 0 -0.5 0 serum_choline serum_phospholipids 0.0395 0.425 no up no no no no Choline+blood 18:1-LPC+blood 0.538345865 0 0 serum_choline serum_phospholipids 0.0395 0.179 no up no no no no Choline+blood 18:1/18:0-PS+blood 0 -0.590686275 0 serum_choline serum_phospholipids 0.0395 0.193 no up no no no no Choline+blood 18:1/20:4-PE+blood 0 -0.531862745 0 serum_choline serum_phospholipids 0.0395 0.0578 no up no up no no Choline+blood 18:1/22:6-PE+blood 0 -0.549019608 0 serum_choline serum_phospholipids 0.0395 0.0047 no up no no up no Choline+blood 18:2-LPA+blood 0 0.656862745 0 serum_choline serum_phospholipids 0.0395 0.00684 no up no dn no up Choline+blood 18:2-LPC+blood 0 0.529411765 0 serum_choline serum_phospholipids 0.0395 0.00743 no up no dn no up Choline+blood 18:3n6+blood -0.609022556 0 0 serum_choline serum_fattyacid 0.0395 0.0463 no up no up no dn Choline+blood 20:0+blood 0 0 0.445470085 yes serum_choline serum_fattyacid 0.0395 0.000278 no up no dn no up Choline+blood 20:2-LPC+blood 0.45112782 0 0 serum_choline serum_phospholipids 0.0395 0.119 no up no no no up Choline+blood 20:3-LPE+blood 0 0 0.448205128 serum_choline serum_phospholipids 0.0395 0.084 no up no no up no Choline+blood 20:5-LPC+blood -0.467669173 0 0 serum_choline serum_phospholipids 0.0395 0.558 no up no no no no Choline+blood 20:5n3+blood -0.523308271 0 0 serum_choline serum_fattyacid 0.0395 0.988 no up no no no no Choline+blood AA+blood 0 0 0.424957265 serum_choline serum_ARA 0.0395 0.212 no up no no no no Choline+blood Arachidonic acid metabolism 0 0 0.420769231 serum_choline kegg 0.0395 NA no up no no no no Choline+blood B cell receptor signaling pathway 0.475438596 0 0.492307692 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Betaine+blood 0.661654135 0.801470588 0 serum_choline serum_choline 0.0395 0.857 no up no no no no Choline+blood Biosynthesis of amino acids -0.470175439 0 0 serum_choline kegg 0.0395 NA no up no no no no Choline+blood cAMP signaling pathway 0.507017544 0 0 yes serum_choline kegg 0.0395 NA no up no no up up Choline+blood Carbon metabolism -0.470175439 0 0 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Cell cycle 0 0 -0.408461538 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Central carbon metabolism in cancer 0 0 -0.443846154 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Chronic myeloid leukemia 0.524561404 0 0.528461538 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Colorectal cancer 0.464912281 0 0 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Coprococcus -0.496240602 0 0 butyrate-producing serum_choline Genus 0.0395 0.612 no up no no no no Choline+blood Glycolysis / Gluconeogenesis -0.545614035 0 -0.55 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Hematopoietic cell lineage 0 0 -0.439230769 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Intestinal immune network for IgA production 0 0 -0.414615385 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Kaposi sarcoma-associated herpesvirus infection 0 0.544117647 0 serum_choline kegg 0.0395 NA no up no no no dn Choline+blood Lachnospira 0 0 0.462329445 butyrate-producing serum_choline Genus 0.0395 0.279 no up no no no no Choline+blood Long-term potentiation 0 0 -0.424615385 serum_choline kegg 0.0395 NA no up no no no up Choline+blood mRNA surveillance pathway 0.526315789 0 0 serum_choline kegg 0.0395 NA no up no no no no Choline+blood NF-kappa B signaling pathway 0 0 0.408461538 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Non-alcoholic fatty liver disease 0.459649123 0 0 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Odoribacter 0 0 0.64175419 butyrate-producing serum_choline Genus 0.0395 0.798 no up no no no no Choline+blood Oocyte meiosis 0 0 -0.494615385 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Pancreatic cancer 0 -0.502941176 0 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Parabacteroides 0 0 0.485211154 serum_choline Genus 0.0395 4.19E-05 no up no no up up Choline+blood Pathways in cancer 0.49122807 0 0 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Phosphatidylinositol signaling system 0 -0.55 0 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Primary immunodeficiency -0.51754386 0 -0.432307692 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Ras signaling pathway 0 -0.614705882 0 yes serum_choline kegg 0.0395 NA no up no no up up Choline+blood Relaxin signaling pathway 0.51754386 0 0 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Signaling pathways regulating pluripotency of stem cells 0.487719298 0 0 serum_choline kegg 0.0395 NA no up no no no no Choline+blood Spliceosome 0 0 -0.420769231 serum_choline kegg 0.0395 NA no up no no no no Choline+blood TCA+stool -0.696011663 0 0 serum_choline stool_bileacids 0.0395 0.458 no up no no no no Choline+blood Wnt signaling pathway 0.480701754 0 0 serum_choline kegg 0.0395 NA no up no no no no Cholinergic synapse 2-Oxocarboxylic acid metabolism -0.534782609 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Adherens junction -0.511304348 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Akkermansia 0 -0.414110093 0 acetate-producing kegg Genus NA 0.23 no no no no no no Cholinergic synapse Alistipes -0.514415385 0 0 kegg Genus NA 0.0114 no no no no up no Cholinergic synapse AMPK signaling pathway 0 0 -0.482368082 kegg kegg NA NA no no no no no no Cholinergic synapse Arginine and proline metabolism 0 0.427865613 0 kegg kegg NA NA no no no no up no Cholinergic synapse Ascorbate and aldarate metabolism -0.411304348 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Autophagy - animal 0.66173913 0 0.437065637 kegg kegg NA NA no no no no no no Cholinergic synapse Autophagy - other 0.540869565 0 0.517889318 kegg kegg NA NA no no no no no no Cholinergic synapse B cell receptor signaling pathway 0 0 0.410553411 kegg kegg NA NA no no no no no no Cholinergic synapse beta-Alanine metabolism -0.53826087 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Biosynthesis of cofactors -0.52 0 -0.402831403 kegg kegg NA NA no no no no no no Cholinergic synapse Butanoate metabolism -0.536521739 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Butyricimonas 0 0.416033771 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Cholinergic synapse C-type lectin receptor signaling pathway 0.546956522 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse cAMP signaling pathway 0.487826087 0 0 yes kegg kegg NA NA no no no no up up Cholinergic synapse Carbon metabolism -0.405217391 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Cardiac muscle contraction 0 -0.416996047 0 kegg kegg NA NA no no no no no up Cholinergic synapse cGMP-PKG signaling pathway 0.546956522 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Circadian rhythm 0.492173913 0 0.560617761 kegg kegg NA NA no no no no no no Cholinergic synapse Citrate cycle (TCA cycle) -0.44 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Cytokine-cytokine receptor interaction 0 0.527667984 0 kegg kegg NA NA no no no no no no Cholinergic synapse Drug metabolism - other enzymes -0.42173913 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse ECM-receptor interaction 0 0.414031621 0 kegg kegg NA NA no no no no up up Cholinergic synapse ErbB signaling pathway 0.594782609 0 0.754697555 kegg kegg NA NA no no no no no no Cholinergic synapse Fatty acid biosynthesis 0.408695652 0.449604743 0 kegg kegg NA NA no no no no no no Cholinergic synapse Fatty acid elongation -0.443478261 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Fatty acid metabolism 0 0.450592885 0 kegg kegg NA NA no no no no no no Cholinergic synapse Fc epsilon RI signaling pathway 0 0 0.475675676 kegg kegg NA NA no no no no no no Cholinergic synapse Ferroptosis 0 0 -0.492921493 kegg kegg NA NA no no no no no no Cholinergic synapse FoxO signaling pathway 0.570434783 0.471343874 0 kegg kegg NA NA no no no no no no Cholinergic synapse Glutathione metabolism -0.420869565 0 -0.425482625 kegg kegg NA NA no no no no no no Cholinergic synapse Glycerolipid metabolism 0 0 0.48030888 kegg kegg NA NA no no no no no up Cholinergic synapse Glycerophospholipid metabolism 0 0 0.445045045 kegg kegg NA NA no no no no no up Cholinergic synapse "Glycine, serine and threonine metabolism" -0.405217391 0 0 kegg kegg NA NA no no no no up no Cholinergic synapse Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0 0.504247104 kegg kegg NA NA no no no no no no Cholinergic synapse Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.527826087 0 0.54980695 kegg kegg NA NA no no no no no no Cholinergic synapse Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.507335907 kegg kegg NA NA no no no no no no Cholinergic synapse Glycosaminoglycan degradation 0 0 0.476447876 kegg kegg NA NA no no no no no up Cholinergic synapse Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 0.436550837 kegg kegg NA NA no no no no no no Cholinergic synapse Hedgehog signaling pathway 0 0 0.603603604 kegg kegg NA NA no no no no no no Cholinergic synapse Hippo signaling pathway -0.48173913 -0.416996047 0 kegg kegg NA NA no no no no no no Cholinergic synapse Hippo signaling pathway - multiple species 0 0 0.580952381 kegg kegg NA NA no no no no no no Cholinergic synapse Inositol phosphate metabolism 0 0 0.43963964 kegg kegg NA NA no no no no no no Cholinergic synapse Linoleic acid metabolism -0.450434783 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Long-term potentiation 0.584347826 0 0.611325611 kegg kegg NA NA no no no no no up Cholinergic synapse Longevity regulating pathway - multiple species 0 0 -0.500900901 kegg kegg NA NA no no no no no no Cholinergic synapse Lysine degradation 0 0 0.556756757 kegg kegg NA NA no no no no no no Cholinergic synapse Mannose type O-glycan biosynthesis 0 0 0.595624196 kegg kegg NA NA no no no no no no Cholinergic synapse MAPK signaling pathway 0.625217391 0.453557312 0.647619048 kegg kegg NA NA no no no no no no Cholinergic synapse Mitophagy - animal 0 0 -0.542084942 kegg kegg NA NA no no no no no no Cholinergic synapse mRNA surveillance pathway 0 0 0.430630631 kegg kegg NA NA no no no no no no Cholinergic synapse Necroptosis 0 0 -0.536164736 kegg kegg NA NA no no no no no no Cholinergic synapse Neurotrophin signaling pathway 0.469565217 0 0.53951094 kegg kegg NA NA no no no no no no Cholinergic synapse Non-homologous end-joining 0 0 -0.408751609 kegg kegg NA NA no no no no no no Cholinergic synapse Notch signaling pathway 0 0 0.670785071 kegg kegg NA NA no no no no no no Cholinergic synapse Other glycan degradation 0 0 0.5003861 kegg kegg NA NA no no no no no no Cholinergic synapse Other types of O-glycan biosynthesis 0 0 0.479279279 kegg kegg NA NA no no no no no no Cholinergic synapse Oxidative phosphorylation 0 -0.415019763 0 kegg kegg NA NA no no no no no no Cholinergic synapse p53 signaling pathway 0.435652174 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Pentose and glucuronate interconversions -0.407826087 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Peroxisome 0 0 -0.589446589 kegg kegg NA NA no no no no no no Cholinergic synapse Phenylalanine metabolism -0.606086957 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Phosphatidylinositol signaling system 0 0 0.558301158 kegg kegg NA NA no no no no no no Cholinergic synapse Platinum drug resistance 0.457391304 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Porphyrin and chlorophyll metabolism 0 0 -0.420849421 kegg kegg NA NA no no no no no no Cholinergic synapse Proteasome 0 -0.468379447 0 kegg kegg NA NA no no no no no no Cholinergic synapse Protein export 0 -0.441699605 0 kegg kegg NA NA no no no no no no Cholinergic synapse Purine metabolism 0 0 -0.452509653 kegg kegg NA NA no no no no no no Cholinergic synapse Pyruvate metabolism 0 0 -0.530501931 kegg kegg NA NA no no no no no no Cholinergic synapse Ras signaling pathway 0 0 0.621621622 yes kegg kegg NA NA no no no no up up Cholinergic synapse Ribosome 0 0 -0.404118404 kegg kegg NA NA no no no no no no Cholinergic synapse RIG-I-like receptor signaling pathway 0.499130435 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse RNA degradation 0 0 0.446589447 kegg kegg NA NA no no no no no no Cholinergic synapse Signaling pathways regulating pluripotency of stem cells 0.574782609 0 0.586872587 kegg kegg NA NA no no no no no no Cholinergic synapse Sphingolipid metabolism 0 0 0.478249678 kegg kegg NA NA no no no no no no Cholinergic synapse Sphingolipid signaling pathway 0.632173913 0 0.565250965 kegg kegg NA NA no no no no no no Cholinergic synapse Starch and sucrose metabolism 0 0.418972332 0 kegg kegg NA NA no no no no no no Cholinergic synapse Steroid hormone biosynthesis -0.45826087 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Sulfur metabolism -0.635652174 0 -0.436036036 kegg kegg NA NA no no no no no no Cholinergic synapse T cell receptor signaling pathway 0.466086957 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse TGF-beta signaling pathway 0 0 0.545688546 kegg kegg NA NA no no no no no no Cholinergic synapse Th1 and Th2 cell differentiation 0 0 0.496782497 kegg kegg NA NA no no no no no no Cholinergic synapse Th17 cell differentiation 0 0 0.441184041 kegg kegg NA NA no no no no no no Cholinergic synapse Tight junction -0.559130435 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse TNF signaling pathway 0.531304348 0 0.451480051 kegg kegg NA NA no no no no no no Cholinergic synapse Toll-like receptor signaling pathway 0.546086957 0 0 yes kegg kegg NA NA no no no no no no Cholinergic synapse Tryptophan metabolism -0.464347826 0 0 kegg kegg NA NA no no no no up no Cholinergic synapse Ubiquinone and other terpenoid-quinone biosynthesis -0.419130435 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Ubiquitin mediated proteolysis 0 -0.414031621 -0.558043758 kegg kegg NA NA no no no no no no Cholinergic synapse "Valine, leucine and isoleucine degradation" -0.437391304 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse Various types of N-glycan biosynthesis 0.432173913 0 0 kegg kegg NA NA no no no no no no Cholinergic synapse VEGF signaling pathway 0.60173913 0 0.687516088 kegg kegg NA NA no no no no no no Cholinergic synapse Wnt signaling pathway 0 0 0.607979408 kegg kegg NA NA no no no no no no Chronic myeloid leukemia 2-Oxocarboxylic acid metabolism 0 0 -0.404118404 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Adherens junction 0 -0.475296443 -0.476190476 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Adipocytokine signaling pathway 0.452173913 0.729249012 0.475675676 kegg kegg NA NA no no no no no no Chronic myeloid leukemia AGE-RAGE signaling pathway in diabetic complications 0 0.488142292 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia "Alanine, aspartate and glutamate metabolism" 0 0.420948617 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Aldosterone-regulated sodium reabsorption 0.491304348 0.548418972 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Amino sugar and nucleotide sugar metabolism -0.530434783 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Amoebiasis 0 0.485177866 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Amphetamine addiction 0 -0.506916996 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Anaerostipes 0 0 -0.471941609 butyrate-producing kegg Genus NA 0.568 no no no no no no Chronic myeloid leukemia Apelin signaling pathway 0 -0.496047431 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Apoptosis 0 0.68972332 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Arachidonic acid metabolism -0.534782609 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Arginine and proline metabolism 0 0.459486166 0 kegg kegg NA NA no no no no up no Chronic myeloid leukemia Autophagy - animal 0.516521739 0.7243083 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Autophagy - other 0.580869565 0.516798419 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Axon guidance 0.532173913 0 0 kegg kegg NA NA no no no no up up Chronic myeloid leukemia B cell receptor signaling pathway 0.616521739 0.801383399 0.763191763 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Bacterial invasion of epithelial cells -0.406086957 -0.455533597 -0.587644788 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Bacteroides 0 -0.425889328 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Chronic myeloid leukemia Basal cell carcinoma 0.577391304 0 0.522265122 kegg kegg NA NA no no no no no no Chronic myeloid leukemia beta-Alanine metabolism -0.537391304 -0.690711462 -0.677992278 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Biosynthesis of cofactors 0 -0.556324111 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Biosynthesis of unsaturated fatty acids -0.635652174 -0.758893281 -0.781981982 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Bladder cancer 0 0.609683794 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Butanoate metabolism -0.417391304 -0.726284585 -0.635263835 kegg kegg NA NA no no no no no no Chronic myeloid leukemia C-type lectin receptor signaling pathway 0.700869565 0.821146245 0.77992278 kegg kegg NA NA no no no no no no Chronic myeloid leukemia cAMP signaling pathway 0.466086957 0.758893281 0.592535393 yes kegg kegg NA NA no no no no up up Chronic myeloid leukemia Carbohydrate digestion and absorption 0.671304348 0.651185771 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Carbon metabolism -0.479130435 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Cellular senescence 0 0.575098814 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Chagas disease 0.625217391 0.811264822 0.546718147 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Chemical carcinogenesis - DNA adducts -0.569565217 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Chemokine signaling pathway 0.434782609 0.467391304 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Circadian entrainment -0.519130435 -0.699604743 0 kegg kegg NA NA no no no no up up Chronic myeloid leukemia Circadian rhythm 0.540869565 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Citrate cycle (TCA cycle) -0.533913043 -0.725296443 -0.421621622 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Collecting duct acid secretion -0.429565217 -0.599802372 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Colorectal cancer 0.589565217 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Cysteine and methionine metabolism -0.469565217 -0.731225296 -0.562676963 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Cytokine-cytokine receptor interaction 0 0 -0.543114543 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Cytosolic DNA-sensing pathway 0.452173913 0.866600791 0.506306306 kegg kegg NA NA no no no no no no Chronic myeloid leukemia DNA replication 0 -0.673913043 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Dopaminergic synapse 0 -0.522727273 0 kegg kegg NA NA no no no no up no Chronic myeloid leukemia Drug metabolism - cytochrome P450 -0.495652174 -0.716403162 -0.5001287 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Drug metabolism - other enzymes -0.590434783 -0.632411067 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia ECM-receptor interaction 0 -0.475296443 0 kegg kegg NA NA no no no no up up Chronic myeloid leukemia EGFR tyrosine kinase inhibitor resistance 0.443478261 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Endometrial cancer 0.79826087 0.841897233 0.568597169 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Epithelial cell signaling in Helicobacter pylori infection 0.467826087 0.627470356 0.427284427 kegg kegg NA NA no no no no no no Chronic myeloid leukemia ErbB signaling pathway 0.730434783 0.639328063 0.406949807 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Estrogen signaling pathway -0.58 -0.758893281 -0.463577864 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Fatty acid elongation -0.64 -0.679841897 -0.825482625 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Fatty acid metabolism -0.431304348 0 -0.402574003 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Fc epsilon RI signaling pathway 0.484347826 0.645256917 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Focal adhesion -0.407826087 -0.591897233 -0.548777349 kegg kegg NA NA no no no no up up Chronic myeloid leukemia Gastric acid secretion -0.483478261 -0.54743083 -0.468211068 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Glucagon signaling pathway 0 -0.425889328 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Glutathione metabolism 0 -0.507905138 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Glycolysis / Gluconeogenesis -0.574782609 -0.623517787 -0.607979408 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.699604743 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Glycosaminoglycan biosynthesis - keratan sulfate 0.411304348 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Glycosphingolipid biosynthesis - globo and isoglobo series -0.414782609 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Glycosphingolipid biosynthesis - lacto and neolacto series 0.573043478 0.609683794 0.496525097 kegg kegg NA NA no no no no no no Chronic myeloid leukemia GnRH secretion 0.677391304 0.696640316 0 kegg kegg NA NA no no no no up up Chronic myeloid leukemia "Growth hormone synthesis, secretion and action" 0 0.424901186 0.558043758 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Hematopoietic cell lineage 0 -0.491106719 -0.598712999 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Hepatitis B 0.673913043 0.727272727 0.81003861 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Hepatitis C 0.542608696 0.860671937 0.752895753 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Hippo signaling pathway 0 -0.483201581 -0.514028314 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Histidine metabolism -0.45826087 0 -0.408494208 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Human papillomavirus infection 0 0.62944664 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Inflammatory mediator regulation of TRP channels 0 -0.453557312 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Insulin resistance 0.78 0.899209486 0.774517375 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Insulin signaling pathway 0 -0.444664032 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia JAK-STAT signaling pathway 0 0.588932806 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Kaposi sarcoma-associated herpesvirus infection 0.508695652 0 0 kegg kegg NA NA no no no no no dn Chronic myeloid leukemia Lachnospira 0 -0.434395862 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Chronic myeloid leukemia Long-term potentiation 0 -0.612648221 0 kegg kegg NA NA no no no no no up Chronic myeloid leukemia Longevity regulating pathway 0.415652174 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Longevity regulating pathway - multiple species -0.471304348 -0.423913043 -0.594594595 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Lysine degradation 0.62173913 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Mannose type O-glycan biosynthesis 0.766956522 0.427865613 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Melanoma 0.646086957 0.780632411 0.571428571 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Metabolism of xenobiotics by cytochrome P450 -0.582608696 -0.739130435 -0.545173745 kegg kegg NA NA no no no no no no Chronic myeloid leukemia MicroRNAs in cancer 0.420869565 0.820158103 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Mismatch repair -0.519130435 -0.805335968 -0.629343629 kegg kegg NA NA no no no no no no Chronic myeloid leukemia mRNA surveillance pathway 0.534782609 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Mucin type O-glycan biosynthesis -0.416521739 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia N-Glycan biosynthesis 0 -0.428853755 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Natural killer cell mediated cytotoxicity 0 0.437747036 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Neurotrophin signaling pathway 0.807826087 0.923913043 0.726126126 kegg kegg NA NA no no no no no no Chronic myeloid leukemia NF-kappa B signaling pathway 0.596521739 0.804347826 0.801287001 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Nicotine addiction 0 0 0.677477477 kegg kegg NA NA no no no no up up Chronic myeloid leukemia NOD-like receptor signaling pathway 0 0.650197628 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Non-homologous end-joining -0.579130435 -0.781620553 -0.630630631 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Notch signaling pathway 0.429565217 0.48715415 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Nucleotide excision repair 0 -0.721343874 -0.479021879 kegg kegg NA NA no no no no no no Chronic myeloid leukemia One carbon pool by folate 0 -0.704545455 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Oocyte meiosis 0 -0.682806324 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Osteoclast differentiation 0 0.508893281 0.4002574 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Other glycan degradation 0 0.445652174 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Other types of O-glycan biosynthesis 0.422608696 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Oxytocin signaling pathway -0.551304348 -0.414031621 -0.465894466 kegg kegg NA NA no no no no no no Chronic myeloid leukemia p53 signaling pathway 0.407826087 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Pathways in cancer 0.502608696 0.617588933 0.421106821 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Pentose and glucuronate interconversions -0.620869565 -0.589920949 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Phenylalanine metabolism -0.562608696 -0.709486166 -0.491891892 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Phospholipase D signaling pathway 0 0.624505929 0.412612613 kegg kegg NA NA no no no no up up Chronic myeloid leukemia Phototransduction 0 -0.718379447 -0.582496782 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Platelet activation -0.51826087 -0.501976285 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia PPAR signaling pathway 0 0.591897233 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Primary bile acid biosynthesis -0.604347826 -0.752964427 -0.702187902 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Prion disease 0 0 -0.418275418 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Prolactin signaling pathway 0 0.649209486 0.566537967 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Propanoate metabolism -0.508695652 -0.727272727 -0.566795367 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Prostate cancer 0.886086957 0.977272727 0.833719434 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Proteasome 0 -0.566205534 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Protein export 0 -0.423913043 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Proximal tubule bicarbonate reclamation -0.460869565 -0.619565217 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Pyrimidine metabolism -0.536521739 -0.691699605 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Pyruvate metabolism -0.523478261 -0.717391304 -0.561647362 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Ras signaling pathway 0 -0.486166008 0 yes kegg kegg NA NA no no no no up up Chronic myeloid leukemia Regulation of actin cytoskeleton -0.492173913 -0.684782609 -0.673873874 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Relaxin signaling pathway 0.673913043 0.813241107 0.649420849 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Renal cell carcinoma 0.58173913 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Renin secretion -0.494782609 -0.593873518 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Retinol metabolism -0.646956522 -0.736166008 -0.433204633 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Retrograde endocannabinoid signaling 0 -0.471343874 0 kegg kegg NA NA no no no no no up Chronic myeloid leukemia Ribosome biogenesis in eukaryotes 0 -0.419960474 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia RIG-I-like receptor signaling pathway 0.67826087 0.808300395 0.773230373 kegg kegg NA NA no no no no no no Chronic myeloid leukemia RNA degradation 0.525217391 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia RNA polymerase 0 -0.423913043 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Roseburia -0.499130435 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no Chronic myeloid leukemia Salivary secretion -0.42173913 -0.449604743 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Salmonella infection 0 0 -0.432432432 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Sarcina 0 0.444554224 0 kegg Genus NA 0.0703 no no no no no no Chronic myeloid leukemia Serotonergic synapse -0.412173913 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Signaling pathways regulating pluripotency of stem cells 0.647826087 0.510869565 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia SNARE interactions in vesicular transport 0 0.523715415 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Sphingolipid signaling pathway 0.433913043 0.56916996 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Spinocerebellar ataxia 0.535652174 0 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Steroid biosynthesis 0 -0.833003953 -0.512226512 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Steroid hormone biosynthesis -0.706956522 -0.831027668 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Sulfur metabolism 0 -0.518774704 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Synthesis and degradation of ketone bodies -0.494782609 -0.730237154 -0.52046332 kegg kegg NA NA no no no no no no Chronic myeloid leukemia T cell receptor signaling pathway 0.528695652 0.654150198 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Taste transduction 0 -0.615612648 0 kegg kegg NA NA no no no no no up Chronic myeloid leukemia Taurine and hypotaurine metabolism 0.406956522 0.533596838 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Terpenoid backbone biosynthesis 0 -0.464426877 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia TGF-beta signaling pathway 0 -0.453557312 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Th1 and Th2 cell differentiation 0.473913043 0.53458498 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Th17 cell differentiation 0.532173913 0.613636364 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Thermogenesis 0 0 -0.412870013 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Thiamine metabolism 0 -0.576086957 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Tight junction -0.409565217 -0.53458498 -0.586357786 kegg kegg NA NA no no no no no no Chronic myeloid leukemia TNF signaling pathway 0.864347826 0.936758893 0.847876448 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Toll-like receptor signaling pathway 0.617391304 0.750988142 0.636293436 yes kegg kegg NA NA no no no no no no Chronic myeloid leukemia Transcriptional misregulation in cancer 0.566086957 0.678853755 0.60978121 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Tryptophan metabolism -0.563478261 -0.787549407 -0.465894466 kegg kegg NA NA no no no no up no Chronic myeloid leukemia Type II diabetes mellitus 0.680869565 0.662055336 0.490604891 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Tyrosine metabolism -0.787826087 -0.889328063 -0.737451737 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Ubiquinone and other terpenoid-quinone biosynthesis -0.534782609 -0.741106719 -0.41029601 kegg kegg NA NA no no no no no no Chronic myeloid leukemia "Valine, leucine and isoleucine degradation" -0.48 -0.73715415 -0.655598456 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Vascular smooth muscle contraction 0 -0.491106719 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia VEGF signaling pathway 0.571304348 0.618577075 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Vibrio cholerae infection -0.439130435 -0.472332016 0 kegg kegg NA NA no no no no no no Chronic myeloid leukemia Viral carcinogenesis 0 0.649209486 0 kegg kegg NA NA no no no no no no Circadian entrainment ABC transporters -0.597391304 0 0 kegg kegg NA NA no up up no up up Circadian entrainment Adherens junction 0 0.64229249 0 kegg kegg NA NA no up up no no no Circadian entrainment Adrenergic signaling in cardiomyocytes 0.607826087 0.518774704 0.585585586 kegg kegg NA NA no up up no no up Circadian entrainment "Alanine, aspartate and glutamate metabolism" -0.499130435 -0.536561265 0 kegg kegg NA NA no up up no no no Circadian entrainment alpha-Linolenic acid metabolism 0 0 -0.503474903 kegg kegg NA NA no up up no no no Circadian entrainment AMPK signaling pathway 0 0 0.428056628 kegg kegg NA NA no up up no no no Circadian entrainment Apelin signaling pathway 0 0.442687747 0 kegg kegg NA NA no up up no no no Circadian entrainment Apoptosis 0 -0.507905138 0 kegg kegg NA NA no up up no no no Circadian entrainment Arachidonic acid metabolism 0 0.453557312 0.453281853 kegg kegg NA NA no up up no no no Circadian entrainment Arginine and proline metabolism 0 -0.483201581 0 kegg kegg NA NA no up up no up no Circadian entrainment Arginine biosynthesis -0.46 -0.486166008 0 kegg kegg NA NA no up up no no no Circadian entrainment Ascorbate and aldarate metabolism 0 0 -0.534620335 kegg kegg NA NA no up up no no no Circadian entrainment Autophagy - animal 0 -0.710474308 -0.538223938 kegg kegg NA NA no up up no no no Circadian entrainment Autophagy - other 0 -0.640316206 0 kegg kegg NA NA no up up no no no Circadian entrainment B cell receptor signaling pathway -0.56 -0.611660079 0 kegg kegg NA NA no up up no no no Circadian entrainment Biosynthesis of cofactors 0 0 0.497039897 kegg kegg NA NA no up up no no no Circadian entrainment C-type lectin receptor signaling pathway 0 -0.747035573 0 kegg kegg NA NA no up up no no no Circadian entrainment Calcium signaling pathway 0 0.466403162 0 kegg kegg NA NA no up up no up up Circadian entrainment Cardiac muscle contraction 0 0.552371542 0 kegg kegg NA NA no up up no no up Circadian entrainment Cell adhesion molecules 0 -0.486166008 0 kegg kegg NA NA no up up no no no Circadian entrainment Cellular senescence 0 -0.507905138 0 kegg kegg NA NA no up up no no no Circadian entrainment Coprococcus 0 0 -0.530536072 butyrate-producing kegg Genus NA 0.612 no up up no no no Circadian entrainment Cytosolic DNA-sensing pathway 0 -0.622529644 0 kegg kegg NA NA no up up no no no Circadian entrainment Drug metabolism - cytochrome P450 0 0.457509881 0 kegg kegg NA NA no up up no no no Circadian entrainment Drug metabolism - other enzymes 0 0.464426877 -0.456885457 kegg kegg NA NA no up up no no no Circadian entrainment Endocrine resistance 0.477391304 0 0.61003861 kegg kegg NA NA no up up no no no Circadian entrainment Endocytosis 0 -0.433794466 0 kegg kegg NA NA no up up no no no Circadian entrainment ErbB signaling pathway 0 -0.530632411 0 kegg kegg NA NA no up up no no no Circadian entrainment Fatty acid biosynthesis 0 -0.471343874 0 kegg kegg NA NA no up up no no no Circadian entrainment Fatty acid degradation 0 -0.485177866 -0.501158301 kegg kegg NA NA no up up no no no Circadian entrainment Fc epsilon RI signaling pathway 0 -0.538537549 -0.405920206 kegg kegg NA NA no up up no no no Circadian entrainment Ferroptosis 0.550434783 0 0.433204633 kegg kegg NA NA no up up no no no Circadian entrainment Focal adhesion 0 0.605731225 0 kegg kegg NA NA no up up no up up Circadian entrainment FoxO signaling pathway 0 -0.468379447 0 kegg kegg NA NA no up up no no no Circadian entrainment Fructose and mannose metabolism 0 -0.420948617 -0.454311454 kegg kegg NA NA no up up no no no Circadian entrainment Galactose metabolism 0 -0.424901186 -0.570913771 kegg kegg NA NA no up up no no no Circadian entrainment Gap junction 0.704347826 0 0.753410553 kegg kegg NA NA no up up no no no Circadian entrainment Glutathione metabolism 0 0.577075099 0.565250965 kegg kegg NA NA no up up no no no Circadian entrainment Glycerolipid metabolism -0.707826087 0 -0.582754183 kegg kegg NA NA no up up no no up Circadian entrainment Glycerophospholipid metabolism 0 0 -0.455598456 kegg kegg NA NA no up up no no up Circadian entrainment "Glycine, serine and threonine metabolism" 0 0 0.490862291 kegg kegg NA NA no up up no up no Circadian entrainment Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.482608696 -0.567193676 -0.438867439 kegg kegg NA NA no up up no no no Circadian entrainment Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.466409266 kegg kegg NA NA no up up no no no Circadian entrainment Glycosaminoglycan degradation 0 0 -0.648906049 kegg kegg NA NA no up up no no up Circadian entrainment Glycosphingolipid biosynthesis - globo and isoglobo series 0.430434783 0 0 kegg kegg NA NA no up up no no no Circadian entrainment Glyoxylate and dicarboxylate metabolism -0.590434783 -0.52173913 0 kegg kegg NA NA no up up no no no Circadian entrainment Hippo signaling pathway 0 0.575098814 0 kegg kegg NA NA no up up no no no Circadian entrainment Hippo signaling pathway - multiple species -0.430434783 0 -0.533333333 kegg kegg NA NA no up up no no no Circadian entrainment Histidine metabolism 0 0 -0.402059202 kegg kegg NA NA no up up no no no Circadian entrainment Inositol phosphate metabolism -0.479130435 0 -0.448648649 kegg kegg NA NA no up up no no no Circadian entrainment JAK-STAT signaling pathway 0 -0.614624506 0 kegg kegg NA NA no up up no no no Circadian entrainment Lachnospira 0 0.523350646 0 butyrate-producing kegg Genus NA 0.279 no up up no no no Circadian entrainment Lysine degradation -0.516521739 0 0 kegg kegg NA NA no up up no no no Circadian entrainment MAPK signaling pathway 0 -0.446640316 -0.556499356 kegg kegg NA NA no up up no no no Circadian entrainment Metabolism of xenobiotics by cytochrome P450 0 0.482213439 0 kegg kegg NA NA no up up no no no Circadian entrainment Mitophagy - animal 0.427826087 0 0 kegg kegg NA NA no up up no no no Circadian entrainment Mucin type O-glycan biosynthesis 0 -0.458498024 0 kegg kegg NA NA no up up no no no Circadian entrainment Natural killer cell mediated cytotoxicity 0 -0.436758893 0 kegg kegg NA NA no up up no no no Circadian entrainment Necroptosis 0.519130435 0 0.451994852 kegg kegg NA NA no up up no no no Circadian entrainment NF-kappa B signaling pathway -0.839130435 -0.707509881 0 kegg kegg NA NA no up up no no no Circadian entrainment Nicotinate and nicotinamide metabolism -0.432173913 0 0 kegg kegg NA NA no up up no no no Circadian entrainment Nitrogen metabolism 0 -0.416007905 0 kegg kegg NA NA no up up no no no Circadian entrainment NOD-like receptor signaling pathway -0.46 -0.77173913 0 kegg kegg NA NA no up up no no no Circadian entrainment Notch signaling pathway 0 0 -0.455083655 kegg kegg NA NA no up up no no no Circadian entrainment One carbon pool by folate 0 0.466403162 0 kegg kegg NA NA no up up no no no Circadian entrainment Oscillospira 0 -0.481225296 0 LPS-producing kegg Genus NA 0.62 no up up no no no Circadian entrainment Osteoclast differentiation -0.542608696 -0.572134387 0 kegg kegg NA NA no up up no no no Circadian entrainment Other glycan degradation -0.60173913 -0.529644269 -0.532561133 kegg kegg NA NA no up up no no no Circadian entrainment Oxidative phosphorylation 0 0.597826087 0 kegg kegg NA NA no up up no no no Circadian entrainment Pantothenate and CoA biosynthesis 0 0 -0.416988417 kegg kegg NA NA no up up no no dn Circadian entrainment Peroxisome -0.466086957 -0.506916996 0 kegg kegg NA NA no up up no no no Circadian entrainment Phenylalanine metabolism 0 0.467391304 0 kegg kegg NA NA no up up no no no Circadian entrainment Platelet activation 0.569565217 0.729249012 0.425482625 kegg kegg NA NA no up up no no no Circadian entrainment Porphyrin and chlorophyll metabolism 0 0 0.460746461 kegg kegg NA NA no up up no no no Circadian entrainment PPAR signaling pathway 0 -0.71541502 0 kegg kegg NA NA no up up no no no Circadian entrainment Proteasome 0 0 -0.404890605 kegg kegg NA NA no up up no no no Circadian entrainment Pyrimidine metabolism 0 0.503952569 -0.400772201 kegg kegg NA NA no up up no no no Circadian entrainment Pyruvate metabolism 0 0.42687747 0 kegg kegg NA NA no up up no no no Circadian entrainment Rap1 signaling pathway 0 0.571146245 0 kegg kegg NA NA no up up no no no Circadian entrainment Ras signaling pathway 0 0.515810277 0 yes kegg kegg NA NA no up up no up up Circadian entrainment Retinol metabolism 0 0.419960474 0 kegg kegg NA NA no up up no no no Circadian entrainment Ribosome 0 0.458498024 0 kegg kegg NA NA no up up no no no Circadian entrainment RIG-I-like receptor signaling pathway -0.512173913 -0.758893281 0 kegg kegg NA NA no up up no no no Circadian entrainment Sarcina 0 -0.422326513 0 kegg Genus NA 0.0703 no up up no no no Circadian entrainment Selenocompound metabolism 0 0 -0.400514801 kegg kegg NA NA no up up no no no Circadian entrainment SNARE interactions in vesicular transport -0.623478261 -0.628458498 0 kegg kegg NA NA no up up no no no Circadian entrainment Sphingolipid metabolism 0 0 -0.456113256 kegg kegg NA NA no up up no no no Circadian entrainment Sphingolipid signaling pathway 0 -0.522727273 0 kegg kegg NA NA no up up no no no Circadian entrainment Spliceosome 0 -0.438735178 0 kegg kegg NA NA no up up no no no Circadian entrainment Starch and sucrose metabolism 0 0 -0.473359073 kegg kegg NA NA no up up no no no Circadian entrainment Steroid biosynthesis 0.49826087 0.47826087 0 kegg kegg NA NA no up up no no no Circadian entrainment Steroid hormone biosynthesis 0 0.516798419 0 kegg kegg NA NA no up up no no no Circadian entrainment T cell receptor signaling pathway 0 -0.847826087 0 kegg kegg NA NA no up up no no no Circadian entrainment TGF-beta signaling pathway 0 0.484189723 0 kegg kegg NA NA no up up no no no Circadian entrainment Th1 and Th2 cell differentiation -0.463478261 -0.630434783 0 kegg kegg NA NA no up up no no no Circadian entrainment Th17 cell differentiation -0.517391304 -0.738142292 0 kegg kegg NA NA no up up no no no Circadian entrainment Tight junction 0 0.548418972 0 kegg kegg NA NA no up up no no no Circadian entrainment TNF signaling pathway 0 -0.722332016 0 kegg kegg NA NA no up up no no no Circadian entrainment Toll-like receptor signaling pathway 0 -0.652173913 0 yes kegg kegg NA NA no up up no no no Circadian entrainment Tyrosine metabolism 0 0.589920949 0 kegg kegg NA NA no up up no no no Circadian entrainment Ubiquitin mediated proteolysis 0.408695652 0 0 kegg kegg NA NA no up up no no no Circadian entrainment Vascular smooth muscle contraction 0.64 0.802371542 0.88030888 kegg kegg NA NA no up up no no no Circadian entrainment VEGF signaling pathway 0 -0.479249012 0 kegg kegg NA NA no up up no no no Circadian entrainment Viral protein interaction with cytokine and cytokine receptor 0 0 0.496267696 kegg kegg NA NA no up up no no no Circadian rhythm 2-Oxocarboxylic acid metabolism -0.668695652 0 0 kegg kegg NA NA no no no no no no Circadian rhythm ABC transporters 0 0.494071146 0 kegg kegg NA NA no no no no up up Circadian rhythm Adherens junction -0.493913043 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Adrenergic signaling in cardiomyocytes 0.67826087 0.515810277 0.539253539 kegg kegg NA NA no no no no no up Circadian rhythm "Alanine, aspartate and glutamate metabolism" 0 0 -0.572715573 kegg kegg NA NA no no no no no no Circadian rhythm alpha-Linolenic acid metabolism -0.70173913 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Amino sugar and nucleotide sugar metabolism -0.617391304 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Aminoacyl-tRNA biosynthesis 0 0.432806324 0 kegg kegg NA NA no no no no no no Circadian rhythm AMPK signaling pathway 0 0.631422925 0 kegg kegg NA NA no no no no no no Circadian rhythm Antifolate resistance 0 0.511857708 0.409266409 kegg kegg NA NA no no no no no no Circadian rhythm Antigen processing and presentation 0 -0.416996047 0 kegg kegg NA NA no no no no no no Circadian rhythm Apelin signaling pathway 0.445217391 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Apoptosis -0.565217391 -0.485177866 -0.613899614 kegg kegg NA NA no no no no no no Circadian rhythm Apoptosis - multiple species 0 0.519762846 0 kegg kegg NA NA no no no no no no Circadian rhythm Arachidonic acid metabolism -0.446956522 0 -0.614414414 kegg kegg NA NA no no no no no no Circadian rhythm Arginine and proline metabolism 0 -0.485177866 0 kegg kegg NA NA no no no no up no Circadian rhythm Arginine biosynthesis 0 -0.42687747 -0.661003861 kegg kegg NA NA no no no no no no Circadian rhythm Ascorbate and aldarate metabolism -0.405217391 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Autophagy - animal 0.511304348 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Autophagy - other 0.731304348 0.529644269 0.854568855 kegg kegg NA NA no no no no no no Circadian rhythm Axon guidance 0.647826087 0 0 kegg kegg NA NA no no no no up up Circadian rhythm Basal transcription factors 0.499130435 0.779644269 0.742857143 kegg kegg NA NA no no no no no no Circadian rhythm Base excision repair 0 0.663043478 0.480823681 kegg kegg NA NA no no no no no no Circadian rhythm beta-Alanine metabolism -0.836521739 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Biosynthesis of amino acids -0.80173913 -0.731225296 -0.831660232 kegg kegg NA NA no no no no no no Circadian rhythm Biosynthesis of cofactors 0 0.448616601 0 kegg kegg NA NA no no no no no no Circadian rhythm Biosynthesis of unsaturated fatty acids -0.44173913 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Butanoate metabolism -0.627826087 0 0 kegg kegg NA NA no no no no no no Circadian rhythm C-type lectin receptor signaling pathway 0.514782609 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Calcium signaling pathway 0.703478261 0 0.566795367 kegg kegg NA NA no no no no up up Circadian rhythm cAMP signaling pathway 0.760869565 0 0 yes kegg kegg NA NA no no no no up up Circadian rhythm Carbon metabolism -0.805217391 -0.580039526 -0.696010296 kegg kegg NA NA no no no no no no Circadian rhythm Cardiac muscle contraction 0.620869565 0 0 kegg kegg NA NA no no no no no up Circadian rhythm Cell adhesion molecules -0.564347826 -0.579051383 -0.412355212 kegg kegg NA NA no no no no no no Circadian rhythm Cell cycle 0.411304348 0.799407115 0.813642214 kegg kegg NA NA no no no no no no Circadian rhythm Cellular senescence 0 -0.442687747 0 kegg kegg NA NA no no no no no no Circadian rhythm cGMP-PKG signaling pathway 0 -0.752964427 0 kegg kegg NA NA no no no no no no Circadian rhythm Chemokine signaling pathway 0 -0.602766798 -0.427799228 kegg kegg NA NA no no no no no no Circadian rhythm Complement and coagulation cascades -0.615652174 -0.70256917 -0.726126126 kegg kegg NA NA no no no no no no Circadian rhythm Cytokine-cytokine receptor interaction 0 -0.598814229 -0.41003861 kegg kegg NA NA no no no no no no Circadian rhythm DNA replication 0 0.483201581 0.522007722 kegg kegg NA NA no no no no no no Circadian rhythm Drug metabolism - other enzymes -0.670434783 0 0 kegg kegg NA NA no no no no no no Circadian rhythm ECM-receptor interaction 0 0 0.456370656 kegg kegg NA NA no no no no up up Circadian rhythm Endocrine resistance 0 0.504940711 0 kegg kegg NA NA no no no no no no Circadian rhythm Endocytosis 0 -0.600790514 0 kegg kegg NA NA no no no no no no Circadian rhythm ErbB signaling pathway 0.53826087 0 0.63011583 kegg kegg NA NA no no no no no no Circadian rhythm Ether lipid metabolism 0.55826087 0.561264822 0.511454311 kegg kegg NA NA no no no no no no Circadian rhythm Fanconi anemia pathway 0 0.644268775 0.598198198 kegg kegg NA NA no no no no no no Circadian rhythm Fatty acid biosynthesis 0 -0.42687747 0 kegg kegg NA NA no no no no no no Circadian rhythm Fatty acid degradation -0.433043478 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Fatty acid elongation -0.682608696 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Fatty acid metabolism -0.577391304 -0.443675889 0 kegg kegg NA NA no no no no no no Circadian rhythm Fc gamma R-mediated phagocytosis -0.410434783 -0.745059289 -0.718918919 kegg kegg NA NA no no no no no no Circadian rhythm Ferroptosis 0 0 -0.414929215 kegg kegg NA NA no no no no no no Circadian rhythm Focal adhesion -0.534782609 0 0 kegg kegg NA NA no no no no up up Circadian rhythm Folate biosynthesis 0 0.467391304 0 kegg kegg NA NA no no no no no no Circadian rhythm Fructose and mannose metabolism -0.728695652 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Galactose metabolism -0.822608696 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Gap junction 0 0 -0.413899614 kegg kegg NA NA no no no no no no Circadian rhythm Glutathione metabolism 0 0 -0.497297297 kegg kegg NA NA no no no no no no Circadian rhythm Glycerolipid metabolism 0 0 0.593050193 kegg kegg NA NA no no no no no up Circadian rhythm Glycerophospholipid metabolism 0 0.454545455 0.689060489 kegg kegg NA NA no no no no no up Circadian rhythm Glycolysis / Gluconeogenesis -0.706086957 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.513913043 0 0.453796654 kegg kegg NA NA no no no no no no Circadian rhythm Glycosaminoglycan biosynthesis - keratan sulfate 0 0.496047431 0.671814672 kegg kegg NA NA no no no no no no Circadian rhythm Glycosaminoglycan degradation 0 -0.5256917 0 kegg kegg NA NA no no no no no up Circadian rhythm Glycosphingolipid biosynthesis - ganglio series 0 0.485177866 0 kegg kegg NA NA no no no no no no Circadian rhythm Glycosphingolipid biosynthesis - lacto and neolacto series 0.426956522 0 0.537194337 kegg kegg NA NA no no no no no no Circadian rhythm Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.515810277 0 kegg kegg NA NA no no no no no no Circadian rhythm Glyoxylate and dicarboxylate metabolism 0 -0.456521739 -0.652509653 kegg kegg NA NA no no no no no no Circadian rhythm Hedgehog signaling pathway 0.620869565 0.747035573 0.813384813 kegg kegg NA NA no no no no no no Circadian rhythm Hippo signaling pathway -0.453913043 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Histidine metabolism -0.624347826 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Homologous recombination 0 0.541501976 0.545688546 kegg kegg NA NA no no no no no no Circadian rhythm IL-17 signaling pathway 0 -0.745059289 -0.551608752 kegg kegg NA NA no no no no no no Circadian rhythm Inositol phosphate metabolism 0 0.486166008 0.538738739 kegg kegg NA NA no no no no no no Circadian rhythm Leukocyte transendothelial migration -0.447826087 -0.482213439 -0.598455598 kegg kegg NA NA no no no no no no Circadian rhythm Linoleic acid metabolism 0 0 0.46048906 kegg kegg NA NA no no no no no no Circadian rhythm Lysine degradation 0 0.781620553 0.847619048 kegg kegg NA NA no no no no no no Circadian rhythm Lysosome 0 -0.81027668 -0.54028314 kegg kegg NA NA no no no no no no Circadian rhythm Mannose type O-glycan biosynthesis 0.553043478 0.712450593 0.862033462 kegg kegg NA NA no no no no no no Circadian rhythm MAPK signaling pathway 0 0 0.422908623 kegg kegg NA NA no no no no no no Circadian rhythm Mitophagy - animal 0.41826087 0 0 kegg kegg NA NA no no no no no no Circadian rhythm mRNA surveillance pathway 0.847826087 0.803359684 0.912741313 kegg kegg NA NA no no no no no no Circadian rhythm N-Glycan biosynthesis 0.413043478 0.58201581 0.638352638 kegg kegg NA NA no no no no no no Circadian rhythm Natural killer cell mediated cytotoxicity -0.443478261 -0.5256917 0 kegg kegg NA NA no no no no no no Circadian rhythm Necroptosis 0 0 -0.405148005 kegg kegg NA NA no no no no no no Circadian rhythm Neuroactive ligand-receptor interaction 0 -0.721343874 -0.595109395 kegg kegg NA NA no no no up up up Circadian rhythm Neutrophil extracellular trap formation -0.530434783 -0.808300395 -0.852509653 kegg kegg NA NA no no no no no no Circadian rhythm Nicotinate and nicotinamide metabolism 0 -0.51284585 -0.484169884 kegg kegg NA NA no no no no no no Circadian rhythm Nitrogen metabolism 0 0 -0.52972973 kegg kegg NA NA no no no no no no Circadian rhythm Non-homologous end-joining -0.612173913 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Notch signaling pathway 0 0 0.624967825 kegg kegg NA NA no no no no no no Circadian rhythm Nucleotide excision repair 0 0.532608696 0 kegg kegg NA NA no no no no no no Circadian rhythm One carbon pool by folate 0 0.514822134 0.529472329 kegg kegg NA NA no no no no no no Circadian rhythm Oocyte meiosis 0.567826087 0 0.601029601 kegg kegg NA NA no no no no no no Circadian rhythm Osteoclast differentiation 0 -0.563241107 -0.472844273 kegg kegg NA NA no no no no no no Circadian rhythm Other types of O-glycan biosynthesis 0.526086957 0.79743083 0.805920206 kegg kegg NA NA no no no no no no Circadian rhythm Oxidative phosphorylation 0.611304348 0 0 kegg kegg NA NA no no no no no no Circadian rhythm p53 signaling pathway 0.570434783 0.5256917 0.57992278 kegg kegg NA NA no no no no no no Circadian rhythm Pantothenate and CoA biosynthesis 0 -0.554347826 -0.465894466 kegg kegg NA NA no no no no no dn Circadian rhythm Pentose phosphate pathway -0.609565217 -0.82312253 -0.742342342 kegg kegg NA NA no no no no no no Circadian rhythm Peroxisome 0 -0.464426877 -0.655598456 kegg kegg NA NA no no no no no no Circadian rhythm Phagosome -0.63826087 -0.739130435 -0.681338481 kegg kegg NA NA no no no no no no Circadian rhythm Phenylalanine metabolism -0.680869565 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Phosphatidylinositol signaling system 0.760869565 0.694664032 0.830888031 kegg kegg NA NA no no no no no no Circadian rhythm PI3K-Akt signaling pathway 0 0 0.418790219 yes kegg kegg NA NA no no no no up up Circadian rhythm Platelet activation -0.527826087 0 -0.501158301 kegg kegg NA NA no no no no no no Circadian rhythm Platinum drug resistance 0 0.625494071 0.514543115 kegg kegg NA NA no no no no no no Circadian rhythm Primary bile acid biosynthesis 0 0 -0.423938224 kegg kegg NA NA no no no no no no Circadian rhythm Protein export 0.717391304 0 0.69009009 kegg kegg NA NA no no no no no no Circadian rhythm Protein processing in endoplasmic reticulum 0 0.635375494 0 kegg kegg NA NA no no no no no no Circadian rhythm Purine metabolism 0 0.457509881 0 kegg kegg NA NA no no no no no no Circadian rhythm Pyrimidine metabolism -0.627826087 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Rap1 signaling pathway -0.409565217 0 -0.510939511 kegg kegg NA NA no no no no no no Circadian rhythm Ras signaling pathway 0.505217391 0 0.75006435 yes kegg kegg NA NA no no no no up up Circadian rhythm Renin-angiotensin system 0 -0.671936759 0 kegg kegg NA NA no no no no no no Circadian rhythm Retinol metabolism -0.497391304 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Ribosome 0.66 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Ribosome biogenesis in eukaryotes 0.430434783 0.757905138 0.748777349 kegg kegg NA NA no no no no no no Circadian rhythm RNA degradation 0.823478261 0.622529644 0.881853282 kegg kegg NA NA no no no no no no Circadian rhythm RNA polymerase 0.56173913 0.743083004 0.567310167 kegg kegg NA NA no no no no no no Circadian rhythm Selenocompound metabolism 0 0.656126482 0.557528958 kegg kegg NA NA no no no no no no Circadian rhythm Signaling pathways regulating pluripotency of stem cells 0.77826087 0.770750988 0.783268983 kegg kegg NA NA no no no no no no Circadian rhythm Sphingolipid signaling pathway 0.609565217 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Spliceosome 0 0.703557312 0.787902188 kegg kegg NA NA no no no no no no Circadian rhythm Starch and sucrose metabolism -0.546956522 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Steroid hormone biosynthesis -0.47826087 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Sulfur metabolism -0.523478261 0 -0.56988417 kegg kegg NA NA no no no no no no Circadian rhythm Synthesis and degradation of ketone bodies 0 0.464426877 0 kegg kegg NA NA no no no no no no Circadian rhythm T cell receptor signaling pathway 0.426086957 0 0.551608752 kegg kegg NA NA no no no no no no Circadian rhythm Taurine and hypotaurine metabolism 0 0.454545455 0.546203346 kegg kegg NA NA no no no no no no Circadian rhythm Terpenoid backbone biosynthesis 0 0.448616601 0.575032175 kegg kegg NA NA no no no no no no Circadian rhythm TGF-beta signaling pathway 0.59826087 0 0.630888031 kegg kegg NA NA no no no no no no Circadian rhythm Tight junction -0.53826087 0 -0.696010296 kegg kegg NA NA no no no no no no Circadian rhythm TNF signaling pathway 0.565217391 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Toll-like receptor signaling pathway 0 -0.461462451 0 yes kegg kegg NA NA no no no no no no Circadian rhythm Tryptophan metabolism -0.648695652 0 0 kegg kegg NA NA no no no no up no Circadian rhythm Tyrosine metabolism -0.573043478 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Ubiquinone and other terpenoid-quinone biosynthesis -0.465217391 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Ubiquitin mediated proteolysis 0.428695652 0.451581028 0 kegg kegg NA NA no no no no no no Circadian rhythm "Valine, leucine and isoleucine degradation" -0.446956522 0 0 kegg kegg NA NA no no no no no no Circadian rhythm Various types of N-glycan biosynthesis 0.505217391 0.599802372 0.591248391 kegg kegg NA NA no no no no no no Circadian rhythm Vascular smooth muscle contraction 0.512173913 0 0 kegg kegg NA NA no no no no no no Circadian rhythm VEGF signaling pathway 0.586956522 0 0.520978121 kegg kegg NA NA no no no no no no Circadian rhythm Viral protein interaction with cytokine and cytokine receptor 0 -0.682806324 -0.417760618 kegg kegg NA NA no no no no no no Circadian rhythm Wnt signaling pathway 0.587826087 0.649209486 0.847361647 kegg kegg NA NA no no no no no no Citrate cycle (TCA cycle) Glycolysis / Gluconeogenesis 0.692173913 0.785573123 0.436550837 kegg kegg NA NA no no no no no no Cloacibacillus 1-68 0 0.408673758 0 Genus Genus 0.933 0.828 no no no no no no Clostridium Eggerthella 0.465757046 0 0 Genus Genus 0.925 0.912 no no no no no no Cocaine addiction 2-Oxocarboxylic acid metabolism 0 0 -0.541055341 kegg kegg NA NA no no no no no no Cocaine addiction ABC transporters -0.444347826 0 0 kegg kegg NA NA no no no no up up Cocaine addiction Adipocytokine signaling pathway 0.410434783 0 0.529472329 kegg kegg NA NA no no no no no no Cocaine addiction Adrenergic signaling in cardiomyocytes 0.570434783 0.677865613 0.675933076 kegg kegg NA NA no no no no no up Cocaine addiction Aldosterone synthesis and secretion 0.77826087 0.779644269 0.78018018 kegg kegg NA NA no no no no up up Cocaine addiction alpha-Linolenic acid metabolism -0.52 0 -0.781467181 kegg kegg NA NA no no no no no no Cocaine addiction Alzheimer disease 0 0.491106719 0 kegg kegg NA NA no no no no no no Cocaine addiction Amino sugar and nucleotide sugar metabolism -0.444347826 0 -0.629343629 kegg kegg NA NA no no no no no no Cocaine addiction AMPK signaling pathway 0.45826087 0.640316206 0.417245817 kegg kegg NA NA no no no no no no Cocaine addiction Amyotrophic lateral sclerosis 0.457391304 0.481225296 0 kegg kegg NA NA no no no no no no Cocaine addiction Antigen processing and presentation -0.417391304 -0.485177866 0 kegg kegg NA NA no no no no no no Cocaine addiction Arginine and proline metabolism -0.487826087 0 0 kegg kegg NA NA no no no no up no Cocaine addiction Arginine biosynthesis -0.405217391 0 0 kegg kegg NA NA no no no no no no Cocaine addiction Ascorbate and aldarate metabolism 0 0 -0.702960103 kegg kegg NA NA no no no no no no Cocaine addiction beta-Alanine metabolism -0.422608696 -0.516798419 -0.663320463 kegg kegg NA NA no no no no no no Cocaine addiction Bile secretion 0.796521739 0.779644269 0.718146718 kegg kegg NA NA no no no no no no Cocaine addiction Biosynthesis of amino acids -0.462608696 -0.579051383 0 kegg kegg NA NA no no no no no no Cocaine addiction Biosynthesis of unsaturated fatty acids -0.452173913 -0.523715415 -0.537194337 kegg kegg NA NA no no no no no no Cocaine addiction Blautia 0 -0.42687747 0 acetate-producing kegg Genus NA 1.36E-05 no no no up dn dn Cocaine addiction Butanoate metabolism 0 0 -0.480566281 kegg kegg NA NA no no no no no no Cocaine addiction Calcium signaling pathway 0.511304348 0.747035573 0.762162162 kegg kegg NA NA no no no no up up Cocaine addiction cAMP signaling pathway 0.449565217 0.425889328 0.827284427 yes kegg kegg NA NA no no no no up up Cocaine addiction Carbon metabolism -0.433913043 -0.729249012 -0.511969112 kegg kegg NA NA no no no no no no Cocaine addiction Cardiac muscle contraction 0 0.484189723 0 kegg kegg NA NA no no no no no up Cocaine addiction Cell adhesion molecules 0 -0.64229249 0 kegg kegg NA NA no no no no no no Cocaine addiction cGMP-PKG signaling pathway 0 -0.449604743 0 kegg kegg NA NA no no no no no no Cocaine addiction Cholesterol metabolism 0 -0.496047431 0 yes kegg kegg NA NA no no no no no up Cocaine addiction Circadian entrainment 0.477391304 0 0.656370656 kegg kegg NA NA no no no no up up Cocaine addiction Circadian rhythm 0 0.438735178 0 kegg kegg NA NA no no no no no no Cocaine addiction Citrate cycle (TCA cycle) -0.431304348 0 -0.617245817 kegg kegg NA NA no no no no no no Cocaine addiction Clostridium 0 -0.511440348 0 kegg Genus NA 0.925 no no no no no no Cocaine addiction Complement and coagulation cascades 0 -0.497035573 0 kegg kegg NA NA no no no no no no Cocaine addiction Cortisol synthesis and secretion 0.94 0.944664032 0.936679537 kegg kegg NA NA no no no no no up Cocaine addiction Cushing syndrome 0.827826087 0.872529644 0.769111969 kegg kegg NA NA no no no no no up Cocaine addiction Cytokine-cytokine receptor interaction 0 -0.419960474 0 kegg kegg NA NA no no no no no no Cocaine addiction Cytosolic DNA-sensing pathway 0 0 0.464092664 kegg kegg NA NA no no no no no no Cocaine addiction Dopaminergic synapse 0.57826087 0.597826087 0.711196911 kegg kegg NA NA no no no no up no Cocaine addiction Drug metabolism - cytochrome P450 0 0 -0.419305019 kegg kegg NA NA no no no no no no Cocaine addiction Drug metabolism - other enzymes -0.496521739 0 -0.537966538 kegg kegg NA NA no no no no no no Cocaine addiction Endocrine and other factor-regulated calcium reabsorption 0.769565217 0.773715415 0.749292149 kegg kegg NA NA no no no no no no Cocaine addiction Endocrine resistance 0.734782609 0.837944664 0.692149292 kegg kegg NA NA no no no no no no Cocaine addiction Endocytosis 0 -0.619565217 0 kegg kegg NA NA no no no no no no Cocaine addiction Fat digestion and absorption 0 -0.438735178 -0.472072072 yes kegg kegg NA NA no no no no up up Cocaine addiction Fatty acid biosynthesis -0.475652174 0 0 kegg kegg NA NA no no no no no no Cocaine addiction Fatty acid degradation -0.709565217 -0.471343874 -0.773230373 kegg kegg NA NA no no no no no no Cocaine addiction Fatty acid elongation -0.434782609 -0.603754941 -0.544658945 kegg kegg NA NA no no no no no no Cocaine addiction Fatty acid metabolism -0.667826087 -0.572134387 -0.712483912 kegg kegg NA NA no no no no no no Cocaine addiction Fc gamma R-mediated phagocytosis -0.674782609 -0.671936759 0 kegg kegg NA NA no no no no no no Cocaine addiction Ferroptosis 0.57826087 0.545454545 0 kegg kegg NA NA no no no no no no Cocaine addiction Fructose and mannose metabolism 0 0 -0.497039897 kegg kegg NA NA no no no no no no Cocaine addiction GABAergic synapse -0.427826087 0 0 kegg kegg NA NA no no no no up up Cocaine addiction Galactose metabolism 0 -0.414031621 -0.566537967 kegg kegg NA NA no no no no no no Cocaine addiction Gap junction 0.682608696 0.720355731 0.635263835 kegg kegg NA NA no no no no no no Cocaine addiction Gastric acid secretion 0.429565217 0 0 kegg kegg NA NA no no no no no no Cocaine addiction Glucagon signaling pathway 0.528695652 0.618577075 0.549292149 kegg kegg NA NA no no no no no no Cocaine addiction Glutamatergic synapse 0.528695652 0.475296443 0.576576577 kegg kegg NA NA no no no no up up Cocaine addiction Glutathione metabolism 0 0.434782609 0 kegg kegg NA NA no no no no no no Cocaine addiction "Glycine, serine and threonine metabolism" 0 0.468379447 0.427284427 kegg kegg NA NA no no no no up no Cocaine addiction Glycolysis / Gluconeogenesis 0 0 -0.482625483 kegg kegg NA NA no no no no no no Cocaine addiction Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.452767053 kegg kegg NA NA no no no no no no Cocaine addiction Glycosaminoglycan biosynthesis - keratan sulfate 0.479130435 0 0 kegg kegg NA NA no no no no no no Cocaine addiction Glycosaminoglycan degradation 0 -0.532608696 -0.543629344 kegg kegg NA NA no no no no no up Cocaine addiction Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.416996047 0 kegg kegg NA NA no no no no no no Cocaine addiction Glyoxylate and dicarboxylate metabolism -0.506956522 0 0 kegg kegg NA NA no no no no no no Cocaine addiction GnRH signaling pathway 0.800869565 0.883399209 0.848133848 kegg kegg NA NA no no no no no no Cocaine addiction "Growth hormone synthesis, secretion and action" 0.563478261 0.62944664 0.732303732 kegg kegg NA NA no no no no no no Cocaine addiction Hematopoietic cell lineage 0 -0.520750988 -0.448133848 kegg kegg NA NA no no no no no no Cocaine addiction Hippo signaling pathway - multiple species -0.420869565 0 -0.423423423 kegg kegg NA NA no no no no no no Cocaine addiction Histidine metabolism -0.453043478 -0.428853755 -0.758043758 kegg kegg NA NA no no no no no no Cocaine addiction Huntington disease 0 0.510869565 0 kegg kegg NA NA no no no no no no Cocaine addiction Inflammatory mediator regulation of TRP channels 0.568695652 0.543478261 0.64015444 kegg kegg NA NA no no no no no no Cocaine addiction Inositol phosphate metabolism 0 0 -0.443758044 kegg kegg NA NA no no no no no no Cocaine addiction Insulin secretion 0.914782609 0.941699605 0.942084942 yes kegg kegg NA NA no no no no up up Cocaine addiction Long-term depression 0.813913043 0.774703557 0.873873874 kegg kegg NA NA no no no no no no Cocaine addiction Longevity regulating pathway 0.488695652 0.463438735 0.414929215 kegg kegg NA NA no no no no no no Cocaine addiction Longevity regulating pathway - multiple species -0.551304348 -0.81027668 -0.475675676 kegg kegg NA NA no no no no no no Cocaine addiction Lysosome 0 -0.56027668 0 kegg kegg NA NA no no no no no no Cocaine addiction Mannose type O-glycan biosynthesis 0.409565217 0 0 kegg kegg NA NA no no no no no no Cocaine addiction Melanogenesis 0.666956522 0.617588933 0.737709138 kegg kegg NA NA no no no no no no Cocaine addiction Metabolism of xenobiotics by cytochrome P450 0 0 -0.436293436 kegg kegg NA NA no no no no no no Cocaine addiction Mineral absorption 0.719130435 0.78458498 0.451994852 kegg kegg NA NA no no no no no no Cocaine addiction Mismatch repair -0.48 0 0 kegg kegg NA NA no no no no no no Cocaine addiction Mitophagy - animal 0.700869565 0.660079051 0 kegg kegg NA NA no no no no no no Cocaine addiction mRNA surveillance pathway 0 0.4743083 0 kegg kegg NA NA no no no no no no Cocaine addiction Mucin type O-glycan biosynthesis -0.431304348 0 0 kegg kegg NA NA no no no no no no Cocaine addiction Natural killer cell mediated cytotoxicity 0 -0.5 0 kegg kegg NA NA no no no no no no Cocaine addiction Necroptosis 0.663478261 0.636363636 0 kegg kegg NA NA no no no no no no Cocaine addiction Neuroactive ligand-receptor interaction -0.603478261 -0.731225296 0 kegg kegg NA NA no no no up up up Cocaine addiction Neutrophil extracellular trap formation -0.432173913 -0.535573123 0 kegg kegg NA NA no no no no no no Cocaine addiction Nicotinate and nicotinamide metabolism -0.590434783 0 0 kegg kegg NA NA no no no no no no Cocaine addiction NOD-like receptor signaling pathway -0.673913043 0 0 kegg kegg NA NA no no no no no no Cocaine addiction Non-alcoholic fatty liver disease 0 0.532608696 0 kegg kegg NA NA no no no no no no Cocaine addiction Non-homologous end-joining -0.429565217 -0.526679842 -0.412097812 kegg kegg NA NA no no no no no no Cocaine addiction Odoribacter 0 -0.547797618 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Cocaine addiction Olfactory transduction -0.56173913 -0.519762846 -0.443243243 kegg kegg NA NA no no no no no no Cocaine addiction Osteoclast differentiation -0.542608696 -0.483201581 0 kegg kegg NA NA no no no no no no Cocaine addiction Other glycan degradation 0 0 -0.4996139 kegg kegg NA NA no no no no no no Cocaine addiction Other types of O-glycan biosynthesis 0 0.446640316 0 kegg kegg NA NA no no no no no no Cocaine addiction Ovarian steroidogenesis 0.684347826 0.818181818 0.73976834 kegg kegg NA NA no no no no up up Cocaine addiction Oxidative phosphorylation 0 0.460474308 0 kegg kegg NA NA no no no no no no Cocaine addiction Pancreatic secretion 0.787826087 0.693675889 0.832689833 kegg kegg NA NA no no no no no no Cocaine addiction Pantothenate and CoA biosynthesis -0.546956522 -0.485177866 -0.524581725 kegg kegg NA NA no no no no no dn Cocaine addiction "Parathyroid hormone synthesis, secretion and action" 0.67826087 0.744071146 0.689317889 kegg kegg NA NA no no no no no no Cocaine addiction Parkinson disease 0.654782609 0.546442688 0.452252252 kegg kegg NA NA no no no no no no Cocaine addiction Pathways of neurodegeneration - multiple diseases 0.653043478 0.556324111 0.422651223 kegg kegg NA NA no no no no no no Cocaine addiction Pentose phosphate pathway 0 -0.564229249 0 kegg kegg NA NA no no no no no no Cocaine addiction Peroxisome -0.757391304 -0.549407115 0 kegg kegg NA NA no no no no no no Cocaine addiction Phagosome 0 -0.612648221 0 kegg kegg NA NA no no no no no no Cocaine addiction Phospholipase D signaling pathway 0 0 0.482625483 kegg kegg NA NA no no no no up up Cocaine addiction Porphyrin and chlorophyll metabolism 0 0.418972332 0 kegg kegg NA NA no no no no no no Cocaine addiction Prevotella 0 0 0.438094835 acetate-producing kegg Genus NA 0.287 no no no no no no Cocaine addiction Primary bile acid biosynthesis -0.507826087 -0.542490119 -0.479279279 kegg kegg NA NA no no no no no no Cocaine addiction Propanoate metabolism -0.408695652 0 0 kegg kegg NA NA no no no no no no Cocaine addiction Proteasome 0 0 -0.456885457 kegg kegg NA NA no no no no no no Cocaine addiction Protein digestion and absorption -0.517391304 -0.595849802 0 yes kegg kegg NA NA no no no no up up Cocaine addiction Purine metabolism 0 0.514822134 0 kegg kegg NA NA no no no no no no Cocaine addiction Pyrimidine metabolism -0.496521739 0 0 kegg kegg NA NA no no no no no no Cocaine addiction Regulation of lipolysis in adipocytes 0.692173913 0.853754941 0.764736165 kegg kegg NA NA no no no no no no Cocaine addiction Relaxin signaling pathway 0.583478261 0.476284585 0.83011583 kegg kegg NA NA no no no no no no Cocaine addiction Renin secretion 0.508695652 0.444664032 0.639382239 kegg kegg NA NA no no no no no no Cocaine addiction Renin-angiotensin system -0.503478261 -0.598814229 0 kegg kegg NA NA no no no no no no Cocaine addiction Retinol metabolism -0.550434783 0 -0.66023166 kegg kegg NA NA no no no no no no Cocaine addiction Ribosome 0.470434783 0 0 kegg kegg NA NA no no no no no no Cocaine addiction RIG-I-like receptor signaling pathway 0 0 0.402059202 kegg kegg NA NA no no no no no no Cocaine addiction Salivary secretion 0.484347826 0 0.541055341 kegg kegg NA NA no no no no no no Cocaine addiction Selenocompound metabolism 0 0 -0.488545689 kegg kegg NA NA no no no no no no Cocaine addiction Serotonergic synapse 0.413043478 0.490118577 0.57014157 kegg kegg NA NA no no no no no no Cocaine addiction Sphingolipid metabolism 0 0 -0.494465894 kegg kegg NA NA no no no no no no Cocaine addiction Starch and sucrose metabolism -0.477391304 0 -0.586615187 kegg kegg NA NA no no no no no no Cocaine addiction Steroid biosynthesis 0 0 -0.45045045 kegg kegg NA NA no no no no no no Cocaine addiction Steroid hormone biosynthesis 0 0 -0.608751609 kegg kegg NA NA no no no no no no Cocaine addiction Synaptic vesicle cycle 0 -0.551383399 -0.473873874 kegg kegg NA NA no no no no up up Cocaine addiction Synthesis and degradation of ketone bodies 0 0 -0.457142857 kegg kegg NA NA no no no no no no Cocaine addiction Terpenoid backbone biosynthesis 0 0 -0.406949807 kegg kegg NA NA no no no no no no Cocaine addiction Thermogenesis 0.450434783 0.438735178 0 kegg kegg NA NA no no no no no no Cocaine addiction Thyroid hormone synthesis 0.754782609 0.919960474 0.687773488 kegg kegg NA NA no no no no no no Cocaine addiction Tryptophan metabolism -0.52173913 -0.484189723 -0.671042471 kegg kegg NA NA no no no no up no Cocaine addiction Type I diabetes mellitus 0 -0.531620553 0 kegg kegg NA NA no no no no no no Cocaine addiction Tyrosine metabolism 0 0 -0.498326898 kegg kegg NA NA no no no no no no Cocaine addiction Ubiquinone and other terpenoid-quinone biosynthesis -0.409565217 0 0 kegg kegg NA NA no no no no no no Cocaine addiction Ubiquitin mediated proteolysis 0.725217391 0.647233202 0 kegg kegg NA NA no no no no no no Cocaine addiction "Valine, leucine and isoleucine degradation" -0.439130435 0 -0.61981982 kegg kegg NA NA no no no no no no Cocaine addiction Vascular smooth muscle contraction 0.587826087 0.418972332 0.599227799 kegg kegg NA NA no no no no no no Cocaine addiction Vasopressin-regulated water reabsorption 0.8 0.720355731 0.762934363 kegg kegg NA NA no no no no no no Collecting duct acid secretion Adrenergic signaling in cardiomyocytes 0 0 -0.54980695 kegg kegg NA NA no no no no no up Collecting duct acid secretion "Alanine, aspartate and glutamate metabolism" 0 0 0.521750322 kegg kegg NA NA no no no no no no Collecting duct acid secretion Aldosterone synthesis and secretion 0 0 -0.515315315 kegg kegg NA NA no no no no up up Collecting duct acid secretion Amino sugar and nucleotide sugar metabolism 0 0 0.462290862 kegg kegg NA NA no no no no no no Collecting duct acid secretion Arachidonic acid metabolism 0 0.532608696 0.704761905 kegg kegg NA NA no no no no no no Collecting duct acid secretion Arginine biosynthesis 0 0 0.570656371 kegg kegg NA NA no no no no no no Collecting duct acid secretion Autophagy - other -0.420869565 -0.599802372 -0.593050193 kegg kegg NA NA no no no no no no Collecting duct acid secretion Axon guidance 0 0 -0.462548263 kegg kegg NA NA no no no no up up Collecting duct acid secretion Basal transcription factors -0.451304348 0 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Base excision repair -0.588695652 0 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion beta-Alanine metabolism 0 0.537549407 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Biosynthesis of amino acids 0 0 0.538738739 kegg kegg NA NA no no no no no no Collecting duct acid secretion Biosynthesis of cofactors 0 0 0.470527671 kegg kegg NA NA no no no no no no Collecting duct acid secretion Biosynthesis of unsaturated fatty acids 0 0.637351779 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Calcium signaling pathway 0 0 -0.63011583 kegg kegg NA NA no no no no up up Collecting duct acid secretion Carbon metabolism 0 0.477272727 0.451994852 kegg kegg NA NA no no no no no no Collecting duct acid secretion Cell cycle 0 0 -0.571428571 kegg kegg NA NA no no no no no no Collecting duct acid secretion cGMP-PKG signaling pathway 0.414782609 0 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Circadian rhythm 0 -0.591897233 -0.63037323 kegg kegg NA NA no no no no no no Collecting duct acid secretion Complement and coagulation cascades 0 0.446640316 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Cushing syndrome 0 -0.444664032 -0.544658945 kegg kegg NA NA no no no no no up Collecting duct acid secretion Cytokine-cytokine receptor interaction 0 0.779644269 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Cytosolic DNA-sensing pathway 0 -0.605731225 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Dopaminergic synapse 0 0 -0.41029601 kegg kegg NA NA no no no no up no Collecting duct acid secretion ECM-receptor interaction -0.523478261 0 0 kegg kegg NA NA no no no no up up Collecting duct acid secretion EGFR tyrosine kinase inhibitor resistance -0.447826087 0 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion ErbB signaling pathway -0.44173913 -0.548418972 -0.568854569 kegg kegg NA NA no no no no no no Collecting duct acid secretion Fatty acid elongation 0 0.489130435 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Fc gamma R-mediated phagocytosis 0.415652174 0.484189723 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Ferroptosis 0 0 0.440926641 kegg kegg NA NA no no no no no no Collecting duct acid secretion Fructose and mannose metabolism 0 0 0.417245817 kegg kegg NA NA no no no no no no Collecting duct acid secretion GABAergic synapse 0 0 0.42960103 kegg kegg NA NA no no no no up up Collecting duct acid secretion Glucagon signaling pathway 0 0 -0.574259974 kegg kegg NA NA no no no no no no Collecting duct acid secretion Glutathione metabolism 0 0 0.616988417 kegg kegg NA NA no no no no no no Collecting duct acid secretion "Glycine, serine and threonine metabolism" 0 0 0.462290862 kegg kegg NA NA no no no no up no Collecting duct acid secretion Glycosaminoglycan biosynthesis - keratan sulfate 0 -0.699604743 -0.487773488 kegg kegg NA NA no no no no no no Collecting duct acid secretion Glycosaminoglycan degradation 0.470434783 0 0 kegg kegg NA NA no no no no no up Collecting duct acid secretion Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 -0.402316602 kegg kegg NA NA no no no no no no Collecting duct acid secretion Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.405217391 0 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Glyoxylate and dicarboxylate metabolism 0 0 0.54980695 kegg kegg NA NA no no no no no no Collecting duct acid secretion GnRH secretion 0 -0.558300395 0 kegg kegg NA NA no no no no up up Collecting duct acid secretion Hedgehog signaling pathway 0 0 -0.573487773 kegg kegg NA NA no no no no no no Collecting duct acid secretion HIF-1 signaling pathway -0.465217391 0 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Inflammatory mediator regulation of TRP channels 0 0 -0.453539254 kegg kegg NA NA no no no no no no Collecting duct acid secretion Insulin resistance 0 0 -0.438352638 kegg kegg NA NA no no no no no no Collecting duct acid secretion Insulin secretion 0 -0.459486166 0 yes kegg kegg NA NA no no no no up up Collecting duct acid secretion Long-term potentiation 0 0 -0.622651223 kegg kegg NA NA no no no no no up Collecting duct acid secretion Longevity regulating pathway - multiple species 0 0.445652174 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Lysine degradation -0.640869565 -0.662055336 -0.478249678 kegg kegg NA NA no no no no no no Collecting duct acid secretion Lysosome 0.491304348 0 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Mannose type O-glycan biosynthesis 0 -0.746047431 -0.514028314 kegg kegg NA NA no no no no no no Collecting duct acid secretion Melanogenesis 0 0 -0.427541828 kegg kegg NA NA no no no no no no Collecting duct acid secretion mRNA surveillance pathway 0 -0.602766798 -0.595109395 kegg kegg NA NA no no no no no no Collecting duct acid secretion N-Glycan biosynthesis -0.453043478 0 -0.518918919 kegg kegg NA NA no no no no no no Collecting duct acid secretion Neuroactive ligand-receptor interaction 0.516521739 0.467391304 0 kegg kegg NA NA no no no up up up Collecting duct acid secretion Neurotrophin signaling pathway 0 -0.461462451 -0.492664093 kegg kegg NA NA no no no no no no Collecting duct acid secretion Neutrophil extracellular trap formation 0.511304348 0.510869565 0.425225225 kegg kegg NA NA no no no no no no Collecting duct acid secretion Nicotinate and nicotinamide metabolism 0.432173913 0 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Nitrogen metabolism 0 0 0.525611326 kegg kegg NA NA no no no no no no Collecting duct acid secretion Non-homologous end-joining 0 0.464426877 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Olfactory transduction 0.588695652 0.66798419 0.45971686 kegg kegg NA NA no no no no no no Collecting duct acid secretion Oocyte meiosis 0 0 -0.554697555 kegg kegg NA NA no no no no no no Collecting duct acid secretion Other glycan degradation 0 -0.416996047 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Other types of O-glycan biosynthesis -0.463478261 -0.516798419 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Oxytocin signaling pathway 0.535652174 0.497035573 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Pantothenate and CoA biosynthesis 0 0.453557312 0.476962677 kegg kegg NA NA no no no no no dn Collecting duct acid secretion Pentose phosphate pathway 0 0.448616601 0.631402831 kegg kegg NA NA no no no no no no Collecting duct acid secretion Peroxisome 0 0.427865613 0.523809524 kegg kegg NA NA no no no no no no Collecting duct acid secretion Phosphatidylinositol signaling system 0 0 -0.454826255 kegg kegg NA NA no no no no no no Collecting duct acid secretion Phototransduction 0 0.446640316 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Platinum drug resistance -0.44 0 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Porphyrin and chlorophyll metabolism 0 0 0.489317889 kegg kegg NA NA no no no no no no Collecting duct acid secretion Primary bile acid biosynthesis 0 0.558300395 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Progesterone-mediated oocyte maturation -0.447826087 0 -0.534620335 kegg kegg NA NA no no no no no no Collecting duct acid secretion Protein export -0.409565217 0 -0.536679537 kegg kegg NA NA no no no no no no Collecting duct acid secretion Purine metabolism 0 0 0.421879022 kegg kegg NA NA no no no no no no Collecting duct acid secretion Ras signaling pathway 0 0 -0.423166023 yes kegg kegg NA NA no no no no up up Collecting duct acid secretion Regulation of actin cytoskeleton 0 0.598814229 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Renin-angiotensin system 0.459130435 0 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Ribosome biogenesis in eukaryotes -0.626086957 0 -0.451737452 kegg kegg NA NA no no no no no no Collecting duct acid secretion RNA degradation 0 -0.436758893 -0.608751609 kegg kegg NA NA no no no no no no Collecting duct acid secretion RNA polymerase -0.546086957 0 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion RNA transport -0.43826087 0 -0.406177606 kegg kegg NA NA no no no no no no Collecting duct acid secretion Selenocompound metabolism -0.43826087 0 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Signaling pathways regulating pluripotency of stem cells 0 -0.743083004 -0.594851995 kegg kegg NA NA no no no no no no Collecting duct acid secretion Spliceosome -0.665217391 -0.515810277 -0.589446589 kegg kegg NA NA no no no no no no Collecting duct acid secretion Starch and sucrose metabolism 0 0 0.534877735 kegg kegg NA NA no no no no no no Collecting duct acid secretion Steroid biosynthesis 0 0.435770751 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Steroid hormone biosynthesis 0 0.456521739 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Sulfur metabolism 0 0 0.735392535 kegg kegg NA NA no no no no no no Collecting duct acid secretion Synaptic vesicle cycle 0.755652174 0.646245059 0.594594595 kegg kegg NA NA no no no no up up Collecting duct acid secretion T cell receptor signaling pathway -0.491304348 -0.470355731 -0.69009009 kegg kegg NA NA no no no no no no Collecting duct acid secretion Taurine and hypotaurine metabolism 0 -0.416996047 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion TGF-beta signaling pathway 0 0 -0.424195624 kegg kegg NA NA no no no no no no Collecting duct acid secretion Tight junction 0.464347826 0 0.547490347 kegg kegg NA NA no no no no no no Collecting duct acid secretion TNF signaling pathway 0 -0.425889328 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Tryptophan metabolism 0 0.45256917 0 kegg kegg NA NA no no no no up no Collecting duct acid secretion Various types of N-glycan biosynthesis -0.486086957 0 -0.547490347 kegg kegg NA NA no no no no no no Collecting duct acid secretion VEGF signaling pathway 0 0 -0.485971686 kegg kegg NA NA no no no no no no Collecting duct acid secretion Viral protein interaction with cytokine and cytokine receptor 0 0.652173913 0 kegg kegg NA NA no no no no no no Collecting duct acid secretion Wnt signaling pathway 0 0 -0.565765766 kegg kegg NA NA no no no no no no Colorectal cancer 2-Oxocarboxylic acid metabolism -0.537391304 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Adrenergic signaling in cardiomyocytes 0.553913043 0 0 kegg kegg NA NA no no no no no up Colorectal cancer AGE-RAGE signaling pathway in diabetic complications 0 0 0.465637066 kegg kegg NA NA no no no no no no Colorectal cancer "Alanine, aspartate and glutamate metabolism" 0 0 -0.40952381 kegg kegg NA NA no no no no no no Colorectal cancer Alcoholism 0 -0.57312253 0 kegg kegg NA NA no no no no no no Colorectal cancer Aldosterone synthesis and secretion 0.509565217 0 0 kegg kegg NA NA no no no no up up Colorectal cancer Aldosterone-regulated sodium reabsorption 0.668695652 0.423913043 0.563449163 kegg kegg NA NA no no no no no no Colorectal cancer Alistipes 0 0.574048318 0 kegg Genus NA 0.0114 no no no no up no Colorectal cancer alpha-Linolenic acid metabolism -0.65826087 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Alzheimer disease 0.654782609 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Amino sugar and nucleotide sugar metabolism -0.728695652 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Aminoacyl-tRNA biosynthesis -0.426956522 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Amphetamine addiction 0.506956522 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Amyotrophic lateral sclerosis 0.654782609 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Antigen processing and presentation 0 -0.440711462 -0.450707851 kegg kegg NA NA no no no no no no Colorectal cancer Apoptosis - multiple species 0 0.416996047 0 kegg kegg NA NA no no no no no no Colorectal cancer Arachidonic acid metabolism -0.593043478 -0.448616601 -0.611583012 kegg kegg NA NA no no no no no no Colorectal cancer Arginine biosynthesis 0 0 -0.466409266 kegg kegg NA NA no no no no no no Colorectal cancer Autophagy - animal 0 0 0.420849421 kegg kegg NA NA no no no no no no Colorectal cancer Autophagy - other 0.463478261 0.43972332 0.663063063 kegg kegg NA NA no no no no no no Colorectal cancer Axon guidance 0.587826087 0 0 kegg kegg NA NA no no no no up up Colorectal cancer B cell receptor signaling pathway 0.463478261 0 0 kegg kegg NA NA no no no no no no Colorectal cancer beta-Alanine metabolism -0.747826087 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Bile secretion 0 0 -0.421879022 kegg kegg NA NA no no no no no no Colorectal cancer Biosynthesis of amino acids -0.77826087 0 -0.54028314 kegg kegg NA NA no no no no no no Colorectal cancer Biosynthesis of cofactors 0 0 -0.43989704 kegg kegg NA NA no no no no no no Colorectal cancer Biosynthesis of unsaturated fatty acids -0.463478261 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Butanoate metabolism -0.607826087 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Butyricimonas 0.474571625 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Colorectal cancer C-type lectin receptor signaling pathway 0.443478261 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Calcium signaling pathway 0.717391304 0 0 kegg kegg NA NA no no no no up up Colorectal cancer cAMP signaling pathway 0.727826087 0 0 yes kegg kegg NA NA no no no no up up Colorectal cancer Carbohydrate digestion and absorption 0.430434783 0.53458498 0.674903475 kegg kegg NA NA no no no no no no Colorectal cancer Carbon metabolism -0.773913043 0 -0.419047619 kegg kegg NA NA no no no no no no Colorectal cancer Cardiac muscle contraction 0.637391304 0 0 kegg kegg NA NA no no no no no up Colorectal cancer Cell adhesion molecules -0.475652174 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Cell cycle 0 0 0.528957529 kegg kegg NA NA no no no no no no Colorectal cancer Chemical carcinogenesis - DNA adducts -0.706956522 -0.528656126 0 kegg kegg NA NA no no no no no no Colorectal cancer Chemical carcinogenesis - receptor activation 0.605217391 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Cholinergic synapse 0.513913043 0 0.802574003 kegg kegg NA NA no no no no no no Colorectal cancer Circadian rhythm 0.752173913 0.501976285 0.680823681 kegg kegg NA NA no no no no no no Colorectal cancer Collecting duct acid secretion 0 -0.572134387 -0.591505792 kegg kegg NA NA no no no no no no Colorectal cancer Collinsella 0 0 -0.506840774 kegg Genus NA 0.128 no no no no no no Colorectal cancer Complement and coagulation cascades -0.720869565 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Coronavirus disease - COVID-19 0.559130435 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Cushing syndrome 0.427826087 0 0 kegg kegg NA NA no no no no no up Colorectal cancer Dopaminergic synapse 0.493913043 0 0 kegg kegg NA NA no no no no up no Colorectal cancer Drug metabolism - cytochrome P450 -0.509565217 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Drug metabolism - other enzymes -0.771304348 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Endocrine resistance 0.540869565 0 0 kegg kegg NA NA no no no no no no Colorectal cancer ErbB signaling pathway 0.72173913 0.611660079 0.897812098 kegg kegg NA NA no no no no no no Colorectal cancer Ether lipid metabolism 0.560869565 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Fat digestion and absorption -0.572173913 0 0 yes kegg kegg NA NA no no no no up up Colorectal cancer Fatty acid degradation -0.477391304 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Fatty acid elongation -0.573913043 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Fatty acid metabolism -0.577391304 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Fc epsilon RI signaling pathway 0.612173913 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Fc gamma R-mediated phagocytosis 0 0 -0.404890605 kegg kegg NA NA no no no no no no Colorectal cancer Ferroptosis 0 0 -0.61029601 kegg kegg NA NA no no no no no no Colorectal cancer Folate biosynthesis 0 0.523715415 0 kegg kegg NA NA no no no no no no Colorectal cancer Fructose and mannose metabolism -0.703478261 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Galactose metabolism -0.633043478 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Gemmiger 0 0.512364247 0 butyrate-producing kegg Genus NA 0.595 no no no no no no Colorectal cancer Glutathione metabolism -0.430434783 0 -0.623423423 kegg kegg NA NA no no no no no no Colorectal cancer Glycerolipid metabolism 0 0 0.583783784 kegg kegg NA NA no no no no no up Colorectal cancer Glycerophospholipid metabolism 0 0 0.574002574 kegg kegg NA NA no no no no no up Colorectal cancer "Glycine, serine and threonine metabolism" 0 0 -0.406177606 kegg kegg NA NA no no no no up no Colorectal cancer Glycolysis / Gluconeogenesis -0.784347826 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0 0.436550837 kegg kegg NA NA no no no no no no Colorectal cancer Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.57312253 0.520978121 kegg kegg NA NA no no no no no no Colorectal cancer Glycosaminoglycan biosynthesis - keratan sulfate 0.66173913 0.712450593 0.535135135 kegg kegg NA NA no no no no no no Colorectal cancer Glycosphingolipid biosynthesis - lacto and neolacto series 0.65826087 0 0.424967825 kegg kegg NA NA no no no no no no Colorectal cancer Glyoxylate and dicarboxylate metabolism -0.43826087 0 -0.457915058 kegg kegg NA NA no no no no no no Colorectal cancer GnRH secretion 0.76 0.527667984 0.829343629 kegg kegg NA NA no no no no up up Colorectal cancer GnRH signaling pathway 0.424347826 0 0 kegg kegg NA NA no no no no no no Colorectal cancer "Growth hormone synthesis, secretion and action" 0.586956522 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Hedgehog signaling pathway 0.799130435 0.524703557 0.760617761 kegg kegg NA NA no no no no no no Colorectal cancer Hepatitis B 0.444347826 0 0.545173745 kegg kegg NA NA no no no no no no Colorectal cancer Hepatitis C 0.424347826 0 0.426254826 kegg kegg NA NA no no no no no no Colorectal cancer Hippo signaling pathway - multiple species 0 0 0.429343629 kegg kegg NA NA no no no no no no Colorectal cancer Histidine metabolism -0.423478261 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Huntington disease 0.657391304 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Inflammatory mediator regulation of TRP channels 0.471304348 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Inositol phosphate metabolism 0 0.515810277 0.598455598 kegg kegg NA NA no no no no no no Colorectal cancer Insulin resistance 0.630434783 0 0.516344916 kegg kegg NA NA no no no no no no Colorectal cancer Kaposi sarcoma-associated herpesvirus infection 0 0 -0.558558559 kegg kegg NA NA no no no no no dn Colorectal cancer Legionellosis -0.479130435 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Leishmaniasis -0.536521739 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Long-term potentiation 0.512173913 0 0.601029601 kegg kegg NA NA no no no no no up Colorectal cancer Lysine degradation 0 0.639328063 0.667953668 kegg kegg NA NA no no no no no no Colorectal cancer Malaria 0 0 -0.654826255 kegg kegg NA NA no no no no no no Colorectal cancer Mannose type O-glycan biosynthesis 0.690434783 0.742094862 0.662548263 kegg kegg NA NA no no no no no no Colorectal cancer MAPK signaling pathway 0 0 0.805920206 kegg kegg NA NA no no no no no no Colorectal cancer Metabolism of xenobiotics by cytochrome P450 -0.602608696 0 0 kegg kegg NA NA no no no no no no Colorectal cancer MicroRNAs in cancer 0 0 0.816216216 kegg kegg NA NA no no no no no no Colorectal cancer Mineral absorption 0 0 -0.57039897 kegg kegg NA NA no no no no no no Colorectal cancer Mitophagy - animal 0 0 -0.554182754 kegg kegg NA NA no no no no no no Colorectal cancer mRNA surveillance pathway 0.775652174 0.456521739 0.636808237 kegg kegg NA NA no no no no no no Colorectal cancer N-Glycan biosynthesis 0 0 0.448391248 kegg kegg NA NA no no no no no no Colorectal cancer Natural killer cell mediated cytotoxicity -0.48 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Necroptosis 0 0 -0.602316602 kegg kegg NA NA no no no no no no Colorectal cancer Neurotrophin signaling pathway 0.654782609 0 0.509137709 kegg kegg NA NA no no no no no no Colorectal cancer Neutrophil extracellular trap formation -0.473043478 0 -0.458429858 kegg kegg NA NA no no no no no no Colorectal cancer Non-alcoholic fatty liver disease 0.690434783 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Non-homologous end-joining -0.599130435 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Notch signaling pathway 0.593913043 0.435770751 0.696267696 kegg kegg NA NA no no no no no no Colorectal cancer Olfactory transduction 0 -0.494071146 0 kegg kegg NA NA no no no no no no Colorectal cancer Other glycan degradation 0 0 0.49034749 kegg kegg NA NA no no no no no no Colorectal cancer Other types of O-glycan biosynthesis 0.468695652 0.514822134 0.625997426 kegg kegg NA NA no no no no no no Colorectal cancer Oxidative phosphorylation 0.603478261 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Oxytocin signaling pathway 0 0 -0.402574003 kegg kegg NA NA no no no no no no Colorectal cancer Pancreatic secretion 0.449565217 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Parabacteroides -0.42173913 0 0 kegg Genus NA 4.19E-05 no no no no up up Colorectal cancer "Parathyroid hormone synthesis, secretion and action" 0.515652174 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Parkinson disease 0.510434783 0 -0.477220077 kegg kegg NA NA no no no no no no Colorectal cancer Pathways in cancer 0.74 0 0.426769627 kegg kegg NA NA no no no no no no Colorectal cancer Pathways of neurodegeneration - multiple diseases 0.505217391 0 -0.471557272 kegg kegg NA NA no no no no no no Colorectal cancer Pentose phosphate pathway -0.487826087 0 -0.43989704 kegg kegg NA NA no no no no no no Colorectal cancer Peroxisome -0.445217391 0 -0.564993565 kegg kegg NA NA no no no no no no Colorectal cancer Pertussis -0.457391304 0 0 kegg kegg NA NA no no no no no dn Colorectal cancer Phagosome -0.540869565 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Phenylalanine metabolism -0.460869565 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Phosphatidylinositol signaling system 0.787826087 0.493083004 0.742857143 kegg kegg NA NA no no no no no no Colorectal cancer Platinum drug resistance 0 0.520750988 0.402316602 kegg kegg NA NA no no no no no no Colorectal cancer Porphyrin and chlorophyll metabolism 0 0 -0.488030888 kegg kegg NA NA no no no no no no Colorectal cancer Primary bile acid biosynthesis -0.416521739 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Prion disease 0.573913043 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Progesterone-mediated oocyte maturation 0 0.481225296 0.687773488 kegg kegg NA NA no no no no no no Colorectal cancer Prolactin signaling pathway 0.539130435 0 0.47001287 kegg kegg NA NA no no no no no no Colorectal cancer Propanoate metabolism -0.451304348 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Protein export 0.506086957 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Purine metabolism 0 0 -0.501673102 kegg kegg NA NA no no no no no no Colorectal cancer Pyrimidine metabolism -0.707826087 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Pyruvate metabolism 0 0 -0.414157014 kegg kegg NA NA no no no no no no Colorectal cancer Ras signaling pathway 0.415652174 0 0.572715573 yes kegg kegg NA NA no no no no up up Colorectal cancer Regulation of actin cytoskeleton -0.417391304 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Relaxin signaling pathway 0.562608696 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Retinol metabolism -0.612173913 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Ribosome 0.562608696 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Ribosome biogenesis in eukaryotes 0 0 0.425225225 kegg kegg NA NA no no no no no no Colorectal cancer RNA degradation 0.80173913 0.424901186 0.617760618 kegg kegg NA NA no no no no no no Colorectal cancer Salmonella infection -0.412173913 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Shigellosis 0 0 -0.643758044 kegg kegg NA NA no no no no no no Colorectal cancer Signaling pathways regulating pluripotency of stem cells 0.886086957 0.752964427 0.842213642 kegg kegg NA NA no no no no no no Colorectal cancer Sphingolipid signaling pathway 0.625217391 0 0.686743887 kegg kegg NA NA no no no no no no Colorectal cancer Spinocerebellar ataxia 0.592173913 0.596837945 0.515315315 kegg kegg NA NA no no no no no no Colorectal cancer Spliceosome 0 0.442687747 0.516859717 kegg kegg NA NA no no no no no no Colorectal cancer Staphylococcus aureus infection -0.500869565 0 -0.451994852 kegg kegg NA NA no no no up no no Colorectal cancer Starch and sucrose metabolism -0.546086957 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Steroid hormone biosynthesis -0.602608696 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Sulfur metabolism -0.59826087 0 -0.616473616 kegg kegg NA NA no no no no no no Colorectal cancer Synaptic vesicle cycle 0 -0.43083004 0 kegg kegg NA NA no no no no up up Colorectal cancer T cell receptor signaling pathway 0 0 0.492921493 kegg kegg NA NA no no no no no no Colorectal cancer Taste transduction 0 0 0.587902188 kegg kegg NA NA no no no no no up Colorectal cancer Taurine and hypotaurine metabolism 0 0 0.451480051 kegg kegg NA NA no no no no no no Colorectal cancer TGF-beta signaling pathway 0.655652174 0 0.607979408 kegg kegg NA NA no no no no no no Colorectal cancer Thermogenesis 0.64173913 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Tight junction 0 0 -0.498584299 kegg kegg NA NA no no no no no no Colorectal cancer TNF signaling pathway 0.49826087 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Tryptophan metabolism -0.587826087 0 0 kegg kegg NA NA no no no no up no Colorectal cancer Type II diabetes mellitus 0.560869565 0.463438735 0.559073359 kegg kegg NA NA no no no no no no Colorectal cancer Tyrosine metabolism -0.562608696 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Ubiquinone and other terpenoid-quinone biosynthesis -0.486086957 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Ubiquitin mediated proteolysis 0 0 -0.55958816 kegg kegg NA NA no no no no no no Colorectal cancer "Valine, leucine and isoleucine degradation" -0.489565217 0 0 kegg kegg NA NA no no no no no no Colorectal cancer Various types of N-glycan biosynthesis 0 0.444664032 0.439124839 kegg kegg NA NA no no no no no no Colorectal cancer VEGF signaling pathway 0.757391304 0 0.793050193 kegg kegg NA NA no no no no no no Colorectal cancer Viral protein interaction with cytokine and cytokine receptor 0 -0.475296443 -0.451737452 kegg kegg NA NA no no no no no no Colorectal cancer Vitamin digestion and absorption 0.688695652 0 0.405920206 kegg kegg NA NA no no no no no no Colorectal cancer Wnt signaling pathway 0.794782609 0.46541502 0.760875161 kegg kegg NA NA no no no no no no Complement and coagulation cascades 2-Oxocarboxylic acid metabolism 0 -0.610671937 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Adrenergic signaling in cardiomyocytes -0.457391304 -0.736166008 0 kegg kegg NA NA no no no no no up Complement and coagulation cascades "Alanine, aspartate and glutamate metabolism" 0.426956522 0.696640316 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades alpha-Linolenic acid metabolism 0.607826087 0.548418972 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Amino sugar and nucleotide sugar metabolism 0.473913043 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Aminoacyl-tRNA biosynthesis 0 -0.603754941 -0.404633205 kegg kegg NA NA no no no no no no Complement and coagulation cascades AMPK signaling pathway 0 -0.611660079 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Antifolate resistance 0 0 -0.425482625 kegg kegg NA NA no no no no no no Complement and coagulation cascades Apelin signaling pathway -0.475652174 -0.548418972 -0.448648649 kegg kegg NA NA no no no no no no Complement and coagulation cascades Apoptosis 0.553913043 0.626482213 0.620849421 kegg kegg NA NA no no no no no no Complement and coagulation cascades Arginine and proline metabolism 0.420869565 0.732213439 0 kegg kegg NA NA no no no no up no Complement and coagulation cascades Arginine biosynthesis 0.524347826 0.739130435 0.492149292 kegg kegg NA NA no no no no no no Complement and coagulation cascades Ascorbate and aldarate metabolism 0 -0.451581028 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Autophagy - animal 0 0.432806324 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Autophagy - other -0.406956522 0 -0.523552124 kegg kegg NA NA no no no no no no Complement and coagulation cascades Basal transcription factors -0.600869565 -0.661067194 -0.655855856 kegg kegg NA NA no no no no no no Complement and coagulation cascades Base excision repair 0 -0.543478261 -0.451480051 kegg kegg NA NA no no no no no no Complement and coagulation cascades beta-Alanine metabolism 0.510434783 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Biosynthesis of amino acids 0.843478261 0.849802372 0.726126126 kegg kegg NA NA no no no no no no Complement and coagulation cascades Biosynthesis of cofactors 0 -0.609683794 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Butanoate metabolism 0 -0.488142292 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Calcium signaling pathway -0.56 -0.494071146 -0.457400257 kegg kegg NA NA no no no no up up Complement and coagulation cascades cAMP signaling pathway -0.52173913 0 0 yes kegg kegg NA NA no no no no up up Complement and coagulation cascades Carbon metabolism 0.650434783 0 0.624195624 kegg kegg NA NA no no no no no no Complement and coagulation cascades Cardiac muscle contraction -0.500869565 -0.643280632 0 kegg kegg NA NA no no no no no up Complement and coagulation cascades Cell adhesion molecules 0.676521739 0.627470356 0.475933076 kegg kegg NA NA no no no no no no Complement and coagulation cascades Cell cycle -0.52173913 -0.751976285 -0.681853282 kegg kegg NA NA no no no no no no Complement and coagulation cascades Cellular senescence 0.610434783 0.586956522 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades cGMP-PKG signaling pathway 0 0.860671937 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Chemokine signaling pathway 0 0.781620553 0.613127413 kegg kegg NA NA no no no no no no Complement and coagulation cascades Citrate cycle (TCA cycle) 0 -0.463438735 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Cysteine and methionine metabolism 0 -0.43972332 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Cytokine-cytokine receptor interaction 0 0.662055336 0.547747748 kegg kegg NA NA no no no no no no Complement and coagulation cascades DNA replication 0 -0.632411067 -0.483397683 kegg kegg NA NA no no no no no no Complement and coagulation cascades Drug metabolism - cytochrome P450 0 -0.517786561 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Drug metabolism - other enzymes 0.50173913 -0.428853755 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades EGFR tyrosine kinase inhibitor resistance -0.48 -0.540513834 -0.462033462 kegg kegg NA NA no no no no no no Complement and coagulation cascades Endocrine resistance -0.543478261 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Endocytosis 0.727826087 0.648221344 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Ether lipid metabolism -0.726086957 -0.747035573 -0.491634492 kegg kegg NA NA no no no no no no Complement and coagulation cascades Fanconi anemia pathway 0 -0.596837945 -0.569369369 kegg kegg NA NA no no no no no no Complement and coagulation cascades Fatty acid biosynthesis 0.443478261 0.756916996 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Fatty acid degradation 0.506086957 0.535573123 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Fatty acid metabolism 0.531304348 0.677865613 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Folate biosynthesis 0 -0.662055336 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Fructose and mannose metabolism 0.565217391 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Galactose metabolism 0.490434783 0.53458498 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Gap junction 0 0 0.412612613 kegg kegg NA NA no no no no no no Complement and coagulation cascades Glutathione metabolism 0 -0.464426877 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Glycerolipid metabolism 0 0 -0.516859717 kegg kegg NA NA no no no no no up Complement and coagulation cascades Glycerophospholipid metabolism 0 0 -0.66023166 kegg kegg NA NA no no no no no up Complement and coagulation cascades "Glycine, serine and threonine metabolism" 0 -0.519762846 0 kegg kegg NA NA no no no no up no Complement and coagulation cascades Glycolysis / Gluconeogenesis 0.6 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.453913043 0.45256917 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.459486166 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Glycosaminoglycan biosynthesis - keratan sulfate -0.491304348 -0.493083004 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Glycosaminoglycan degradation 0 0.516798419 0 kegg kegg NA NA no no no no no up Complement and coagulation cascades Glycosphingolipid biosynthesis - ganglio series -0.417391304 -0.464426877 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Glycosphingolipid biosynthesis - lacto and neolacto series -0.514782609 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.517786561 -0.445045045 kegg kegg NA NA no no no no no no Complement and coagulation cascades Glyoxylate and dicarboxylate metabolism 0.494782609 0.759881423 0.501158301 kegg kegg NA NA no no no no no no Complement and coagulation cascades Hedgehog signaling pathway -0.609565217 -0.645256917 -0.729214929 kegg kegg NA NA no no no no no no Complement and coagulation cascades Hippo signaling pathway - multiple species 0 0.489130435 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Homologous recombination 0 -0.418972332 -0.531788932 kegg kegg NA NA no no no no no no Complement and coagulation cascades Inositol phosphate metabolism 0 0 -0.518146718 kegg kegg NA NA no no no no no no Complement and coagulation cascades Lysine degradation 0 -0.631422925 -0.72998713 kegg kegg NA NA no no no no no no Complement and coagulation cascades Lysosome 0 0.777667984 0.498841699 kegg kegg NA NA no no no no no no Complement and coagulation cascades Mannose type O-glycan biosynthesis -0.526956522 -0.587944664 -0.67027027 kegg kegg NA NA no no no no no no Complement and coagulation cascades Metabolism of xenobiotics by cytochrome P450 0 -0.431818182 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Mismatch repair 0 -0.427865613 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Mitophagy - animal -0.444347826 -0.59486166 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades mRNA surveillance pathway -0.811304348 -0.864624506 -0.825225225 kegg kegg NA NA no no no no no no Complement and coagulation cascades mTOR signaling pathway 0 -0.550395257 -0.477220077 kegg kegg NA NA no no no no no no Complement and coagulation cascades N-Glycan biosynthesis -0.505217391 -0.779644269 -0.436036036 kegg kegg NA NA no no no no no no Complement and coagulation cascades Neuroactive ligand-receptor interaction 0 0.817193676 0.675160875 kegg kegg NA NA no no no up up up Complement and coagulation cascades NF-kappa B signaling pathway 0 0.440711462 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Nicotinate and nicotinamide metabolism 0.56 0.795454545 0.452509653 kegg kegg NA NA no no no no no no Complement and coagulation cascades Nitrogen metabolism 0.656521739 0.740118577 0.419047619 kegg kegg NA NA no no no no no no Complement and coagulation cascades Notch signaling pathway -0.411304348 0 -0.43011583 kegg kegg NA NA no no no no no no Complement and coagulation cascades Nucleotide excision repair 0 -0.588932806 -0.404375804 kegg kegg NA NA no no no no no no Complement and coagulation cascades One carbon pool by folate 0 -0.617588933 -0.542599743 kegg kegg NA NA no no no no no no Complement and coagulation cascades Oocyte meiosis -0.545217391 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Osteoclast differentiation 0.494782609 0.781620553 0.510939511 kegg kegg NA NA no no no no no no Complement and coagulation cascades Other types of O-glycan biosynthesis -0.589565217 -0.566205534 -0.697039897 kegg kegg NA NA no no no no no no Complement and coagulation cascades Oxidative phosphorylation -0.546956522 -0.621541502 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades p53 signaling pathway -0.43826087 0 -0.617503218 kegg kegg NA NA no no no no no no Complement and coagulation cascades Pantothenate and CoA biosynthesis 0.470434783 0.792490119 0 kegg kegg NA NA no no no no no dn Complement and coagulation cascades Parabacteroides 0 0 0.453053608 kegg Genus NA 4.19E-05 no no no no up up Complement and coagulation cascades Pentose and glucuronate interconversions 0 -0.690711462 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Pentose phosphate pathway 0.733913043 0.904150198 0.585328185 kegg kegg NA NA no no no no no no Complement and coagulation cascades Peroxisome 0.474782609 0.766798419 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Phagosome 0.74173913 0.779644269 0.630888031 kegg kegg NA NA no no no no no no Complement and coagulation cascades Phosphatidylinositol signaling system -0.732173913 -0.438735178 -0.708365508 kegg kegg NA NA no no no no no no Complement and coagulation cascades Phospholipase D signaling pathway 0 0.418972332 0 kegg kegg NA NA no no no no up up Complement and coagulation cascades PI3K-Akt signaling pathway 0 0 -0.432947233 yes kegg kegg NA NA no no no no up up Complement and coagulation cascades Porphyrin and chlorophyll metabolism 0 -0.497035573 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades PPAR signaling pathway 0.466086957 0.627470356 0.472329472 kegg kegg NA NA no no no no no no Complement and coagulation cascades Primary bile acid biosynthesis 0 0 0.452767053 kegg kegg NA NA no no no no no no Complement and coagulation cascades Protein export -0.76 -0.64229249 -0.610553411 kegg kegg NA NA no no no no no no Complement and coagulation cascades Protein processing in endoplasmic reticulum 0 -0.839920949 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Purine metabolism 0 -0.652173913 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Pyrimidine metabolism 0.419130435 -0.482213439 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Pyruvate metabolism 0 -0.529644269 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Rap1 signaling pathway 0 0 0.510939511 kegg kegg NA NA no no no no no no Complement and coagulation cascades Ras signaling pathway 0 -0.459486166 -0.427799228 yes kegg kegg NA NA no no no no up up Complement and coagulation cascades Ribosome -0.726086957 -0.511857708 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Ribosome biogenesis in eukaryotes -0.56 -0.745059289 -0.688803089 kegg kegg NA NA no no no no no no Complement and coagulation cascades RNA degradation -0.825217391 -0.849802372 -0.746203346 kegg kegg NA NA no no no no no no Complement and coagulation cascades RNA polymerase -0.532173913 -0.852766798 -0.536422136 kegg kegg NA NA no no no no no no Complement and coagulation cascades RNA transport 0 -0.504940711 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Selenocompound metabolism 0 0 -0.556241956 kegg kegg NA NA no no no no no no Complement and coagulation cascades Signaling pathways regulating pluripotency of stem cells -0.512173913 0 -0.536936937 kegg kegg NA NA no no no no no no Complement and coagulation cascades Sphingolipid signaling pathway 0 0.492094862 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Spliceosome 0 -0.449604743 -0.693436293 kegg kegg NA NA no no no no no no Complement and coagulation cascades Starch and sucrose metabolism 0.644347826 0.718379447 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Steroid biosynthesis -0.555652174 0 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Synthesis and degradation of ketone bodies 0 -0.462450593 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Taurine and hypotaurine metabolism 0 0 -0.549292149 kegg kegg NA NA no no no no no no Complement and coagulation cascades Terpenoid backbone biosynthesis -0.497391304 0 -0.435263835 kegg kegg NA NA no no no no no no Complement and coagulation cascades TGF-beta signaling pathway -0.708695652 -0.473320158 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Thiamine metabolism 0 -0.468379447 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Tight junction 0 0 0.506048906 kegg kegg NA NA no no no no no no Complement and coagulation cascades Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.43972332 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Ubiquitin mediated proteolysis -0.552173913 -0.706521739 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades "Valine, leucine and isoleucine degradation" 0 -0.524703557 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Various types of N-glycan biosynthesis 0 -0.636363636 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Vascular smooth muscle contraction -0.466086957 -0.463438735 0 kegg kegg NA NA no no no no no no Complement and coagulation cascades Viral protein interaction with cytokine and cytokine receptor 0 0.666996047 0.644015444 kegg kegg NA NA no no no no no no Complement and coagulation cascades Wnt signaling pathway -0.680869565 -0.798418972 -0.662033462 kegg kegg NA NA no no no no no no Coprobacillus Clostridium 0.445005021 0 0 Genus Genus 0.289 0.925 no no no no no no Coprococcus Actinomyces 0 0.474174387 0 butyrate-producing Genus Genus 0.612 0.621 no no no no no no Coronavirus disease - COVID-19 ABC transporters 0 -0.526679842 0 kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Adherens junction 0 0.56027668 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Adrenergic signaling in cardiomyocytes 0.602608696 0.687747036 0 kegg kegg NA NA no no no no no up Coronavirus disease - COVID-19 African trypanosomiasis 0 -0.592885375 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 AGE-RAGE signaling pathway in diabetic complications 0 -0.769762846 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Akkermansia -0.471598474 0 0 acetate-producing kegg Genus NA 0.23 no no no no no no Coronavirus disease - COVID-19 "Alanine, aspartate and glutamate metabolism" -0.544347826 -0.657114625 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Aldosterone synthesis and secretion 0.549565217 0.671936759 0 kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Aldosterone-regulated sodium reabsorption 0 0 -0.553667954 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 alpha-Linolenic acid metabolism -0.512173913 -0.811264822 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Alzheimer disease 0.706956522 0.881422925 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Amino sugar and nucleotide sugar metabolism -0.53826087 -0.431818182 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Amoebiasis 0 -0.624505929 -0.407464607 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Amphetamine addiction 0.57826087 0.630434783 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Amyotrophic lateral sclerosis 0.744347826 0.811264822 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Apelin signaling pathway 0.710434783 0.919960474 0.838352638 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Apoptosis -0.64173913 -0.616600791 -0.441441441 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Apoptosis - multiple species 0 -0.535573123 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Arginine and proline metabolism -0.427826087 -0.68083004 0 kegg kegg NA NA no no no no up no Coronavirus disease - COVID-19 Arginine biosynthesis -0.615652174 -0.599802372 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Autophagy - animal 0 -0.652173913 -0.427284427 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Autophagy - other 0.462608696 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 B cell receptor signaling pathway 0 -0.586956522 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Bacterial invasion of epithelial cells -0.434782609 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Bacteroides -0.426086957 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Coronavirus disease - COVID-19 Basal transcription factors 0.428695652 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 beta-Alanine metabolism -0.606956522 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Biosynthesis of amino acids -0.775652174 -0.486166008 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Biosynthesis of unsaturated fatty acids -0.519130435 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Butanoate metabolism 0 0.431818182 0.535907336 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 C-type lectin receptor signaling pathway 0 -0.540513834 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Calcium signaling pathway 0.586086957 0.606719368 0 kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 cAMP signaling pathway 0.557391304 0 0 yes kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Carbohydrate digestion and absorption 0 -0.472332016 -0.452509653 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Carbon metabolism -0.633043478 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Cardiac muscle contraction 0.64 0.835968379 0 kegg kegg NA NA no no no no no up Coronavirus disease - COVID-19 Cell adhesion molecules -0.530434783 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 cGMP-PKG signaling pathway 0 -0.517786561 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Chagas disease 0 -0.529644269 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Cholinergic synapse 0 0 -0.406177606 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Circadian entrainment 0 0.440711462 0 kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Circadian rhythm 0.664347826 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Citrate cycle (TCA cycle) 0 0.468379447 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Cocaine addiction 0.46173913 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Complement and coagulation cascades -0.711304348 -0.495059289 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Cortisol synthesis and secretion 0.428695652 0 0 kegg kegg NA NA no no no no no up Coronavirus disease - COVID-19 Cushing syndrome 0.506086957 0 0 kegg kegg NA NA no no no no no up Coronavirus disease - COVID-19 Cysteine and methionine metabolism 0 0.649209486 0.542084942 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 DNA replication 0 0.425889328 0.435263835 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Dopaminergic synapse 0.542608696 0.590909091 0 kegg kegg NA NA no no no no up no Coronavirus disease - COVID-19 Drug metabolism - cytochrome P450 0 0.533596838 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Drug metabolism - other enzymes 0 0.588932806 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 EGFR tyrosine kinase inhibitor resistance 0.712173913 0.897233202 0.816731017 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Endocrine and other factor-regulated calcium reabsorption 0.423478261 0.673913043 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Endocytosis -0.490434783 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Epithelial cell signaling in Helicobacter pylori infection 0 -0.497035573 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 ErbB signaling pathway 0 -0.427865613 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Ether lipid metabolism 0.68 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Fat digestion and absorption -0.58173913 -0.5256917 0 yes kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Fatty acid biosynthesis -0.492173913 -0.690711462 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Fatty acid degradation -0.616521739 -0.68972332 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Fatty acid elongation -0.577391304 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Fatty acid metabolism -0.744347826 -0.636363636 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Fc epsilon RI signaling pathway 0 -0.706521739 -0.63989704 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Fc gamma R-mediated phagocytosis -0.797391304 -0.543478261 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Focal adhesion 0 0.479249012 0 kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 FoxO signaling pathway 0 -0.743083004 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Fructose and mannose metabolism -0.554782609 -0.696640316 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 GABAergic synapse -0.455652174 -0.505928854 -0.401801802 kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Galactose metabolism -0.704347826 -0.754940711 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Gastric acid secretion 0 0.574110672 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Glucagon signaling pathway 0.542608696 0.665019763 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Glutathione metabolism 0 0.729249012 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Glycerolipid metabolism 0 -0.718379447 0 kegg kegg NA NA no no no no no up Coronavirus disease - COVID-19 Glycerophospholipid metabolism 0 -0.544466403 0 kegg kegg NA NA no no no no no up Coronavirus disease - COVID-19 Glycolysis / Gluconeogenesis -0.49826087 0.627470356 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.766798419 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Glycosaminoglycan biosynthesis - keratan sulfate 0.519130435 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Glycosaminoglycan degradation 0 -0.528656126 0 kegg kegg NA NA no no no no no up Coronavirus disease - COVID-19 Glycosphingolipid biosynthesis - lacto and neolacto series 0 -0.498023715 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Glyoxylate and dicarboxylate metabolism -0.637391304 -0.57312253 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 GnRH secretion 0 -0.448616601 0 kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 GnRH signaling pathway 0.425217391 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Hedgehog signaling pathway 0.434782609 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Hepatitis B 0 -0.745059289 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 HIF-1 signaling pathway 0.562608696 0.883399209 0.792535393 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Hippo signaling pathway 0 0.516798419 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Hippo signaling pathway - multiple species 0 -0.787549407 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Human papillomavirus infection -0.471304348 -0.448616601 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Huntington disease 0.724347826 0.863636364 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 IL-17 signaling pathway -0.435652174 -0.416007905 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Inflammatory mediator regulation of TRP channels 0.51826087 0.681818182 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Influenza A -0.457391304 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Inositol phosphate metabolism 0 -0.553359684 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Insulin resistance 0.424347826 -0.56916996 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Insulin secretion 0.420869565 0 0 yes kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Insulin signaling pathway 0.708695652 0.895256917 0.777863578 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 JAK-STAT signaling pathway 0 -0.805335968 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Kaposi sarcoma-associated herpesvirus infection 0.536521739 0.440711462 0.484942085 kegg kegg NA NA no no no no no dn Coronavirus disease - COVID-19 Legionellosis 0 0.646245059 0.517631918 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Leishmaniasis 0 0.584980237 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Leukocyte transendothelial migration -0.405217391 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Long-term potentiation 0.428695652 0.516798419 0 kegg kegg NA NA no no no no no up Coronavirus disease - COVID-19 Lysine degradation 0.433043478 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Malaria 0 0 0.417503218 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Mannose type O-glycan biosynthesis 0.606086957 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 MAPK signaling pathway 0 -0.565217391 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Measles 0 0 0.529214929 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Melanogenesis 0.429565217 0.711462451 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Metabolism of xenobiotics by cytochrome P450 0 0.47826087 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Mineral absorption 0.584347826 0.519762846 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Mitophagy - animal 0.766956522 0.757905138 0.541055341 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Morphine addiction 0 0.45256917 0 kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 mRNA surveillance pathway 0.754782609 0.549407115 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 mTOR signaling pathway 0.712173913 0.889328063 0.783011583 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 N-Glycan biosynthesis 0 0.497035573 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Natural killer cell mediated cytotoxicity -0.486956522 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Necroptosis 0.50173913 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Neuroactive ligand-receptor interaction -0.509565217 -0.46541502 0 kegg kegg NA NA no no no up up up Coronavirus disease - COVID-19 Neurotrophin signaling pathway 0.414782609 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Neutrophil extracellular trap formation -0.756521739 -0.500988142 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 NF-kappa B signaling pathway 0 -0.733201581 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Nicotinate and nicotinamide metabolism -0.529565217 -0.700592885 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Nitrogen metabolism -0.565217391 -0.484189723 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 NOD-like receptor signaling pathway -0.531304348 -0.654150198 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Non-alcoholic fatty liver disease 0.72173913 0.805335968 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Non-homologous end-joining -0.484347826 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Notch signaling pathway 0 -0.420948617 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Olfactory transduction -0.484347826 -0.46541502 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Oocyte meiosis 0.504347826 0.554347826 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Oscillospira 0 -0.476284585 0 LPS-producing kegg Genus NA 0.62 no no no no no no Coronavirus disease - COVID-19 Osteoclast differentiation -0.570434783 -0.635375494 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Other glycan degradation 0 -0.640316206 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Other types of O-glycan biosynthesis 0.457391304 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Oxidative phosphorylation 0.692173913 0.85770751 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Pancreatic secretion 0.459130435 0.600790514 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Pantothenate and CoA biosynthesis -0.625217391 -0.735177866 0 kegg kegg NA NA no no no no no dn Coronavirus disease - COVID-19 "Parathyroid hormone synthesis, secretion and action" 0.692173913 0.781620553 0.484169884 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Parkinson disease 0.82173913 0.860671937 0.58996139 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Pathogenic Escherichia coli infection -0.586086957 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Pathways of neurodegeneration - multiple diseases 0.823478261 0.855731225 0.575546976 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Pentose and glucuronate interconversions 0 0.491106719 0.416988417 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Pentose phosphate pathway -0.655652174 -0.471343874 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Peroxisome -0.58 -0.601778656 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Pertussis -0.737391304 -0.579051383 -0.455598456 kegg kegg NA NA no no no no no dn Coronavirus disease - COVID-19 Phagosome -0.630434783 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Phosphatidylinositol signaling system 0.517391304 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Phospholipase D signaling pathway 0 -0.711462451 -0.490604891 kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Phototransduction 0 0.59486166 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 PI3K-Akt signaling pathway 0 0 0.621621622 yes kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Platinum drug resistance 0 -0.427865613 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 PPAR signaling pathway 0 -0.469367589 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Prion disease 0.633913043 0.887351779 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Prolactin signaling pathway 0 -0.635375494 -0.502702703 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Propanoate metabolism 0 0.663043478 0.647361647 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Proteasome 0 0.541501976 0.434491634 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Protein digestion and absorption -0.528695652 -0.726284585 -0.523809524 yes kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Protein export 0.677391304 0.757905138 0.526898327 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Protein processing in endoplasmic reticulum 0 0.571146245 0.64015444 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Proximal tubule bicarbonate reclamation 0 0.48715415 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Pyrimidine metabolism -0.474782609 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Pyruvate metabolism 0 0.725296443 0.590990991 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Ras signaling pathway 0 0.435770751 0 yes kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Regulation of actin cytoskeleton 0 0.457509881 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Relaxin signaling pathway 0.525217391 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Renin secretion 0 0.67687747 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Renin-angiotensin system -0.479130435 -0.481225296 -0.449420849 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Retinol metabolism -0.47826087 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Retrograde endocannabinoid signaling 0.415652174 0.864624506 0 kegg kegg NA NA no no no no no up Coronavirus disease - COVID-19 Ribosome 0.999130435 0.999011858 0.9997426 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Ribosome biogenesis in eukaryotes 0.424347826 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 RIG-I-like receptor signaling pathway 0 -0.646245059 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 RNA degradation 0.740869565 0.645256917 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 RNA polymerase 0.528695652 0.504940711 0.465122265 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 RNA transport 0 0.81916996 0.607722008 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Ruminococcus 0.437391304 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Coronavirus disease - COVID-19 Salmonella infection -0.604347826 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Shigellosis 0.683478261 0.783596838 0.52972973 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Signaling pathways regulating pluripotency of stem cells 0.526956522 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 SNARE interactions in vesicular transport 0 -0.764822134 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Spinocerebellar ataxia 0.54 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Staphylococcus aureus infection -0.737391304 0 0 kegg kegg NA NA no no no up no no Coronavirus disease - COVID-19 Starch and sucrose metabolism -0.634782609 -0.757905138 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Synaptic vesicle cycle 0 -0.460474308 0 kegg kegg NA NA no no no no up up Coronavirus disease - COVID-19 Taurine and hypotaurine metabolism 0 -0.485177866 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 TGF-beta signaling pathway 0.66173913 0.727272727 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Thermogenesis 0.754782609 0.890316206 0.542857143 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Thiamine metabolism 0 0.590909091 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Thyroid hormone signaling pathway 0 0.477272727 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Thyroid hormone synthesis 0.470434783 0.463438735 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Tight junction 0 0.453557312 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 TNF signaling pathway 0 -0.556324111 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Toll-like receptor signaling pathway 0 -0.580039526 0 yes kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Toxoplasmosis -0.473913043 -0.450592885 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Tuberculosis -0.726086957 -0.462450593 0 kegg kegg NA NA no no no no no dn Coronavirus disease - COVID-19 Type II diabetes mellitus 0 -0.591897233 -0.505019305 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Ubiquitin mediated proteolysis 0.786086957 0.749011858 0.566537967 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Vascular smooth muscle contraction 0.68173913 0.681818182 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Vasopressin-regulated water reabsorption 0.423478261 0.643280632 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 VEGF signaling pathway 0 -0.41798419 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Vibrio cholerae infection 0 0.467391304 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Vitamin digestion and absorption 0.466086957 0 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Wnt signaling pathway 0.604347826 0.554347826 0 kegg kegg NA NA no no no no no no Coronavirus disease - COVID-19 Yersinia infection -0.55826087 0 0 kegg kegg NA NA no no no no no no Cortisol synthesis and secretion 2-Oxocarboxylic acid metabolism 0 0 -0.51042471 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Adipocytokine signaling pathway 0 0 0.441184041 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Adrenergic signaling in cardiomyocytes 0.592173913 0.636363636 0.716344916 kegg kegg NA NA no no up no no up Cortisol synthesis and secretion Aldosterone synthesis and secretion 0.810434783 0.79743083 0.85971686 kegg kegg NA NA no no up no up up Cortisol synthesis and secretion alpha-Linolenic acid metabolism -0.503478261 0 -0.682625483 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Amino sugar and nucleotide sugar metabolism 0 0 -0.498584299 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion AMPK signaling pathway 0.551304348 0.681818182 0.405405405 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Antigen processing and presentation -0.546956522 -0.584980237 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Arginine and proline metabolism -0.577391304 0 0 kegg kegg NA NA no no up no up no Cortisol synthesis and secretion Arginine biosynthesis -0.432173913 0 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Ascorbate and aldarate metabolism 0 0 -0.5997426 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion beta-Alanine metabolism 0 -0.421936759 -0.612612613 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Biosynthesis of amino acids -0.480869565 -0.665019763 -0.432689833 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Biosynthesis of cofactors 0 0.472332016 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Biosynthesis of unsaturated fatty acids 0 0 -0.413127413 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Butanoate metabolism 0 0 -0.43963964 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Calcium signaling pathway 0.540869565 0.626482213 0.796911197 kegg kegg NA NA no no up no up up Cortisol synthesis and secretion cAMP signaling pathway 0.425217391 0 0.730759331 yes kegg kegg NA NA no no up no up up Cortisol synthesis and secretion Carbon metabolism -0.439130435 -0.773715415 -0.619305019 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Cell adhesion molecules 0 -0.735177866 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Cell cycle 0 0.41798419 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Cellular senescence 0 -0.506916996 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion cGMP-PKG signaling pathway 0 -0.545454545 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Circadian entrainment 0.511304348 0 0.681595882 kegg kegg NA NA no no up no up up Cortisol synthesis and secretion Circadian rhythm 0 0.583992095 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Citrate cycle (TCA cycle) 0 0 -0.584041184 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Clostridium 0 -0.498195877 0 kegg Genus NA 0.925 no no up no no no Cortisol synthesis and secretion Complement and coagulation cascades 0 -0.549407115 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Cytokine-cytokine receptor interaction 0 -0.420948617 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Dopaminergic synapse 0.584347826 0.570158103 0.724066924 kegg kegg NA NA no no up no up no Cortisol synthesis and secretion Drug metabolism - other enzymes -0.520869565 0 -0.625740026 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Endocrine resistance 0.844347826 0.887351779 0.795881596 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Endocytosis 0 -0.719367589 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Ether lipid metabolism 0.407826087 0.429841897 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Fatty acid biosynthesis -0.499130435 0 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Fatty acid degradation -0.66 0 -0.773230373 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Fatty acid elongation -0.455652174 -0.549407115 -0.487258687 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Fatty acid metabolism -0.663478261 -0.480237154 -0.708108108 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Fc gamma R-mediated phagocytosis -0.713913043 -0.730237154 -0.421621622 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Ferroptosis 0.512173913 0.43083004 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Fructose and mannose metabolism 0 0 -0.53976834 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion GABAergic synapse -0.422608696 0 0 kegg kegg NA NA no no up no up up Cortisol synthesis and secretion Galactose metabolism -0.41826087 0 -0.557014157 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Gap junction 0.755652174 0.68083004 0.640669241 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Glucagon signaling pathway 0.634782609 0.68972332 0.641698842 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Glutamatergic synapse 0.548695652 0.473320158 0.564736165 kegg kegg NA NA no no up no up up Cortisol synthesis and secretion Glutathione metabolism 0 0.463438735 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Glycerophospholipid metabolism 0 0.416996047 0 kegg kegg NA NA no no up no no up Cortisol synthesis and secretion "Glycine, serine and threonine metabolism" 0.413043478 0.545454545 0 kegg kegg NA NA no no up no up no Cortisol synthesis and secretion Glycolysis / Gluconeogenesis 0 0 -0.544144144 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Glycosaminoglycan biosynthesis - keratan sulfate 0.473913043 0 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Glycosaminoglycan degradation 0 -0.577075099 -0.553410553 kegg kegg NA NA no no up no no up Cortisol synthesis and secretion Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.536561265 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Glyoxylate and dicarboxylate metabolism -0.533043478 0 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion GnRH signaling pathway 0.800869565 0.912055336 0.825997426 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Hematopoietic cell lineage 0 -0.471343874 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Hippo signaling pathway - multiple species -0.471304348 0 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Histidine metabolism -0.451304348 0 -0.666409266 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion IL-17 signaling pathway -0.429565217 -0.5256917 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Inflammatory mediator regulation of TRP channels 0.656521739 0.54743083 0.761389961 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Insulin secretion 0.953913043 0.953557312 0.975546976 yes kegg kegg NA NA no no up no up up Cortisol synthesis and secretion Leukocyte transendothelial migration 0 -0.45256917 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Long-term depression 0.795652174 0.651185771 0.873873874 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Longevity regulating pathway 0.579130435 0.48715415 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Longevity regulating pathway - multiple species -0.423478261 -0.725296443 -0.411583012 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Lysine degradation 0 0.489130435 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Lysosome -0.416521739 -0.704545455 -0.447104247 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Melanogenesis 0.72 0.589920949 0.828314028 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Metabolism of xenobiotics by cytochrome P450 0 0 -0.416473616 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Mitophagy - animal 0.673913043 0.600790514 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion mRNA surveillance pathway 0 0.517786561 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Natural killer cell mediated cytotoxicity 0 -0.617588933 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Necroptosis 0.670434783 0.540513834 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Neuroactive ligand-receptor interaction -0.629565217 -0.798418972 -0.419305019 kegg kegg NA NA no no up up up up Cortisol synthesis and secretion Neutrophil extracellular trap formation -0.52173913 -0.637351779 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Nicotinate and nicotinamide metabolism -0.605217391 0 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion NOD-like receptor signaling pathway -0.702608696 0 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Non-homologous end-joining 0 -0.423913043 -0.420592021 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Notch signaling pathway 0 0.416996047 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Odoribacter 0 -0.653791009 0 butyrate-producing kegg Genus NA 0.798 no no up no no no Cortisol synthesis and secretion Olfactory transduction -0.542608696 -0.563241107 -0.542599743 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Osteoclast differentiation -0.623478261 -0.554347826 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Other types of O-glycan biosynthesis 0 0.623517787 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Ovarian steroidogenesis 0.799130435 0.81027668 0.758043758 kegg kegg NA NA no no up no up up Cortisol synthesis and secretion p53 signaling pathway 0 0.427865613 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Pantothenate and CoA biosynthesis -0.526956522 -0.448616601 -0.593307593 kegg kegg NA NA no no up no no dn Cortisol synthesis and secretion Pentose phosphate pathway 0 -0.681818182 -0.424453024 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Peroxisome -0.730434783 -0.517786561 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Phagosome 0 -0.740118577 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Phospholipase D signaling pathway 0 0 0.514285714 kegg kegg NA NA no no up no up up Cortisol synthesis and secretion Porphyrin and chlorophyll metabolism 0.423478261 0.468379447 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion PPAR signaling pathway -0.412173913 -0.457509881 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Prevotella 0 0 0.520652881 acetate-producing kegg Genus NA 0.287 no no up no no no Cortisol synthesis and secretion Primary bile acid biosynthesis -0.413913043 -0.455533597 -0.434749035 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Proteasome 0 0 -0.571428571 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Purine metabolism 0.444347826 0.554347826 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Pyrimidine metabolism -0.488695652 0 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Regulation of lipolysis in adipocytes 0.793043478 0.835968379 0.814157014 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Relaxin signaling pathway 0.53826087 0 0.719176319 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Renin secretion 0.560869565 0.434782609 0.70990991 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Renin-angiotensin system -0.583478261 -0.675889328 -0.45971686 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Retinol metabolism -0.439130435 0 -0.512483912 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Ribosome 0.436521739 0 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion RNA polymerase 0 0.43083004 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Serotonergic synapse 0.453913043 0.455533597 0.476447876 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Signaling pathways regulating pluripotency of stem cells 0 0.445652174 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Sphingolipid metabolism 0 0 -0.505276705 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Sphingolipid signaling pathway 0 -0.523715415 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Starch and sucrose metabolism -0.544347826 0 -0.621106821 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Steroid hormone biosynthesis 0 0 -0.568597169 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Synaptic vesicle cycle -0.417391304 -0.626482213 -0.535392535 kegg kegg NA NA no no up no up up Cortisol synthesis and secretion Taurine and hypotaurine metabolism 0 0.482213439 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Th17 cell differentiation 0 -0.425889328 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Thermogenesis 0.426956522 0 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Thyroid hormone synthesis 0.788695652 0.888339921 0.683397683 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Tryptophan metabolism -0.46173913 0 -0.640926641 kegg kegg NA NA no no up no up no Cortisol synthesis and secretion Ubiquitin mediated proteolysis 0.708695652 0.638339921 0 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion "Valine, leucine and isoleucine degradation" 0 0 -0.484942085 kegg kegg NA NA no no up no no no Cortisol synthesis and secretion Vascular smooth muscle contraction 0.552173913 0 0.56036036 kegg kegg NA NA no no up no no no CR+clinic 13-HODE+blood 0 0.628571429 0 clinic serum_ARA 0.978 0.32 no no no no no no CR+clinic 14:0/18:2-PC+blood 0 -0.582142857 -0.485384615 clinic serum_phospholipids 0.978 0.102 no no no no up no CR+clinic 14:0/20:4-PC+blood 0 0 -0.499230769 clinic serum_phospholipids 0.978 0.486 no no no no no no CR+clinic 16:0/18:0-PS+blood 0 -0.596428571 0 clinic serum_phospholipids 0.978 0.377 no no no no no no CR+clinic 16:0/18:2-PI+blood 0 0 -0.628461538 clinic serum_phospholipids 0.978 0.269 no no no no no no CR+clinic 16:0/20:4-PC+blood 0.558307534 0 0 clinic serum_phospholipids 0.978 0.0262 no no no no up no CR+clinic 16:0/20:4-PI+blood 0 -0.571428571 -0.473076923 clinic serum_phospholipids 0.978 0.558 no no no no no no CR+clinic 18:0/18:0-PS+blood 0 -0.657142857 0 clinic serum_phospholipids 0.978 0.00617 no no no no up no CR+clinic 18:0/18:2-PI+blood 0 0 -0.486153846 clinic serum_phospholipids 0.978 0.179 no no no no no no CR+clinic 18:0/20:2-PC+blood 0 -0.535714286 0 clinic serum_phospholipids 0.978 0.733 no no no no no no CR+clinic 18:0/20:4-PC+blood 0.490196078 0 0 clinic serum_phospholipids 0.978 0.454 no no no no no no CR+clinic 18:0/20:4-PI+blood 0.595459236 -0.682142857 0 clinic serum_phospholipids 0.978 0.167 no no no no no no CR+clinic 18:0+blood 0 0 -0.427692308 clinic serum_fattyacid 0.978 0.344 no no no no no no CR+clinic 18:1-LPC+blood 0.574819401 0 0 clinic serum_phospholipids 0.978 0.179 no no no no no no CR+clinic 18:1/18:2-PI+blood 0 0 -0.416153846 clinic serum_phospholipids 0.978 0.0164 no no no dn no up CR+clinic 18:2-LPA+blood 0.475748194 0 0 clinic serum_phospholipids 0.978 0.00684 no no no dn no up CR+clinic 2-hydroxyhippuric acid+urine 0 0 0.452307692 clinic urine_cometabolism 0.978 0.215 no no no no no no CR+clinic 20:1+blood 0 0.596428571 0 yes clinic serum_fattyacid 0.978 2.56E-05 no no no dn dn dn CR+clinic 20:3/16:0-PC+blood 0.572755418 0 0 clinic serum_phospholipids 0.978 0.00405 no no no no up up CR+clinic 4-hydroxy-3-methoxymandelic acid+urine 0 0 -0.403846154 clinic urine_cometabolism 0.978 0.973 no no no no no no CR+clinic 5-Hydroxyindole-3-acetic Acid+urine 0 0.632352941 0.416153846 clinic urine_cometabolism 0.978 0.0405 no no no no dn dn CR+clinic 9-HODE+blood 0 0.653571429 0 clinic serum_ARA 0.978 0.297 no no no no no no CR+clinic AA+blood 0 0.560714286 0 clinic serum_ARA 0.978 0.212 no no no no no no CR+clinic Adipocytokine signaling pathway 0 0 -0.508683473 clinic kegg 0.978 NA no no no no no no CR+clinic Alcoholism -0.450028233 0 0 clinic kegg 0.978 NA no no no no no no CR+clinic Anaerostipes -0.530296771 0 0 butyrate-producing clinic Genus 0.978 0.568 no no no no no no CR+clinic Asthma 0.437605872 0 0 clinic kegg 0.978 NA no no no no no no CR+clinic CA+stool -0.541176471 -0.645454545 0 clinic stool_bileacids 0.978 0.827 no no no no no no CR+clinic Calcium signaling pathway 0 0 -0.406162465 clinic kegg 0.978 NA no no no no up up CR+clinic cAMP signaling pathway 0 0 -0.445098039 yes clinic kegg 0.978 NA no no no no up up CR+clinic Carbon metabolism 0 -0.471428571 0 clinic kegg 0.978 NA no no no no no no CR+clinic CDCA+blood -0.562435501 0 0 clinic serum_bileacids 0.978 0.506 no no no no no no CR+clinic CDCA+stool -0.517647059 0 0 clinic stool_bileacids 0.978 0.663 no no no no no no CR+clinic Chemical carcinogenesis - receptor activation 0 0 -0.416246499 clinic kegg 0.978 NA no no no no no no CR+clinic Cholinergic synapse 0 -0.555844156 0 clinic kegg 0.978 NA no no no no no no CR+clinic Chronic myeloid leukemia 0 0 -0.416526611 clinic kegg 0.978 NA no no no no no no CR+clinic Cocaine addiction 0 0 -0.608403361 clinic kegg 0.978 NA no no no no no no CR+clinic Cortisol synthesis and secretion 0 0 -0.578991597 clinic kegg 0.978 NA no no no no no up CR+clinic Creatinine+blood 0.86377709 0.55 0.788461538 clinic serum_choline 0.978 0.437 no no no no no no CR+clinic Cushing syndrome 0 0 -0.531932773 clinic kegg 0.978 NA no no no no no up CR+clinic Cytokine-cytokine receptor interaction 0 -0.571428571 0 clinic kegg 0.978 NA no no no no no no CR+clinic Cytosolic DNA-sensing pathway -0.425183512 0.485714286 0 clinic kegg 0.978 NA no no no no no no CR+clinic d18:0-24:1-SM+blood 0 -0.646428571 0 clinic serum_phospholipids 0.978 0.0609 no no no no dn dn CR+clinic d18:1-14:0-SM+blood 0 -0.567857143 0 clinic serum_phospholipids 0.978 0.94 no no no no no no CR+clinic d18:1-22:1-SM+blood 0 0 -0.407692308 clinic serum_phospholipids 0.978 0.222 no no no no no no CR+clinic Dorea 0 -0.469923769 0 clinic Genus 0.978 0.00362 no no no up no dn CR+clinic Endocrine resistance 0 0 -0.438935574 clinic kegg 0.978 NA no no no no no no CR+clinic Eotaxin 0 0.536842105 0 clinic serum_cytokines 0.978 0.393 no no no no no no CR+clinic Ethanolamine+blood 0.572755418 0 0 clinic serum_aminoacids 0.978 0.122 no no no up no no CR+clinic Fc gamma R-mediated phagocytosis 0 0 0.418487395 clinic kegg 0.978 NA no no no no no no CR+clinic GCA+stool -0.526470588 0 0 clinic stool_bileacids 0.978 0.0809 no no no no no no CR+clinic "Growth hormone synthesis, secretion and action" 0 0 -0.522408964 clinic kegg 0.978 NA no no no no no no CR+clinic HDCA+stool 0.758823529 0 0 clinic stool_bileacids 0.978 0.176 no no no no no no CR+clinic Hematopoietic cell lineage 0.53811406 0 0 clinic kegg 0.978 NA no no no no no no CR+clinic Hepatitis C 0 0 -0.467787115 clinic kegg 0.978 NA no no no no no no CR+clinic IL-1ra 0 -0.578947368 0 yes clinic serum_cytokines 0.978 0.0288 no no no no up no CR+clinic Indole-3-Acetic acid+urine 0 0 0.530769231 clinic urine_cometabolism 0.978 0.657 no no no no no no CR+clinic Inflammatory bowel disease 0.58554489 0 0 clinic kegg 0.978 NA no no no no no no CR+clinic Insulin secretion 0 0 -0.547619048 yes clinic kegg 0.978 NA no no no no up up CR+clinic iso-DCA+blood 0 0.657142857 0 clinic serum_bileacids 0.978 0.38 no no no no no no CR+clinic L-Alanine+blood 0 0 -0.502307692 yes clinic serum_aminoacids 0.978 0.00138 no no no up up no CR+clinic L-Arginine+blood 0.576883385 0 0 clinic serum_aminoacids 0.978 0.316 no no no no no no CR+clinic L-Asparagine+blood 0.479876161 0 0.420769231 clinic serum_aminoacids 0.978 0.784 no no no no no no CR+clinic L-Citrulline+blood 0.609907121 0.553571429 0 clinic serum_aminoacids 0.978 0.534 no no no no no no CR+clinic L-Glutamic acid+blood 0.572755418 0 0 yes clinic serum_aminoacids 0.978 6.20E-05 no no no up up no CR+clinic L-Histidine+blood 0.473684211 0 0 clinic serum_aminoacids 0.978 0.109 no no no no no no CR+clinic L-Isoleucine+blood 0.562435501 0 0 yes clinic serum_aminoacids 0.978 5.47E-06 no no no up up no CR+clinic L-Lysine+blood 0.587203302 0 0 yes clinic serum_aminoacids 0.978 0.0107 no no no no up no CR+clinic L-Methionine+blood 0.583075335 0 0.42 clinic serum_aminoacids 0.978 0.626 no no no no no no CR+clinic L-Ornithine+blood 0 0.7 0 clinic serum_aminoacids 0.978 0.175 no no no no no no CR+clinic L-Tryptophan+blood 0.667698658 0 0 clinic serum_aminoacids 0.978 0.164 no no no no no no CR+clinic L-Tyrosine+urine 0 -0.575980392 0 clinic urine_cometabolism 0.978 0.45 no no no no no no CR+clinic Leptin -0.501976285 -0.460191982 -0.622307105 clinic DM-assocaited hormones 0.978 0.706 no no no no no no CR+clinic Leukocyte transendothelial migration -0.435347261 0 0 clinic kegg 0.978 NA no no no no no no CR+clinic Long-term depression 0 0 -0.527731092 clinic kegg 0.978 NA no no no no no no CR+clinic Longevity regulating pathway - multiple species 0 -0.506493506 0.454061625 clinic kegg 0.978 NA no no no no no no CR+clinic MCP-1(MCAF) 0.675824176 0 0 yes clinic serum_cytokines 0.978 0.0633 no no no dn no no CR+clinic Morphine addiction 0 0 -0.426890756 clinic kegg 0.978 NA no no no no up up CR+clinic MUFA%+blood 0.481940144 0 0.6 clinic serum_fattyacid 0.978 0.00142 no no no up no dn CR+clinic n6/n3+blood 0.539731682 0 0 clinic serum_fattyacid 0.978 0.226 no no no no no no CR+clinic Neuroactive ligand-receptor interaction 0 0 0.451540616 clinic kegg 0.978 NA no no no up up up CR+clinic nutriCA+blood -0.529387576 0 0 clinic serum_bileacids 0.978 0.726 no no no no no no CR+clinic nutriCA+stool 0 -0.788156942 0 clinic stool_bileacids 0.978 0.481 no no no no no no CR+clinic P-hydroxyhippuric acid+urine 0 0.56372549 0 clinic urine_cometabolism 0.978 0.436 no no no no no no CR+clinic PDGF-bb 0 0.489473684 0 yes clinic serum_cytokines 0.978 0.111 no no no no no no CR+clinic Relaxin signaling pathway 0 0 -0.559943978 clinic kegg 0.978 NA no no no no no no CR+clinic RIG-I-like receptor signaling pathway 0 0 -0.482913165 clinic kegg 0.978 NA no no no no no no CR+clinic Small cell lung cancer 0 0 -0.48767507 clinic kegg 0.978 NA no no no no no up CR+clinic Toxoplasmosis 0.446640316 0 0 clinic kegg 0.978 NA no no no no no no CR+clinic Tuberculosis 0 0 0.407843137 clinic kegg 0.978 NA no no no no no dn CR+clinic TUDCA+stool 0 0.705458603 0 clinic stool_bileacids 0.978 0.241 no no no no no no CR+clinic Valine+blood 0.587203302 0 0 yes clinic serum_aminoacids 0.978 1.22E-06 no no no up up no CR+clinic Viral protein interaction with cytokine and cytokine receptor -0.437605872 0 0 clinic kegg 0.978 NA no no no no no no Creatinine+blood 14:0-LPC+blood -0.502255639 0 0 serum_choline serum_phospholipids 0.437 0.00689 no no no up up no Creatinine+blood 14:0/18:2-PC+blood -0.511278195 -0.495098039 -0.422905983 serum_choline serum_phospholipids 0.437 0.102 no no no no up no Creatinine+blood 14:0/20:4-PC+blood -0.613533835 0 -0.53982906 serum_choline serum_phospholipids 0.437 0.486 no no no no no no Creatinine+blood 14:1/18:2-PG+blood -0.448120301 0 -0.527521368 serum_choline serum_phospholipids 0.437 0.00259 no no no no up up Creatinine+blood 16:0/14:0-PC+blood 0.506766917 0 0 serum_choline serum_phospholipids 0.437 0.0206 no no no no up up Creatinine+blood 16:0/16:0-PI+blood 0 0 -0.472136752 serum_choline serum_phospholipids 0.437 0.358 no no no no no no Creatinine+blood 16:0/16:1-PI+blood -0.604511278 0 0 serum_choline serum_phospholipids 0.437 0.262 no no no no no no Creatinine+blood 16:0/18:1-PC+blood 0.461654135 0 0 serum_choline serum_phospholipids 0.437 6.15E-07 no no no up up up Creatinine+blood 16:0/18:2-PI+blood 0 0 -0.411965812 serum_choline serum_phospholipids 0.437 0.269 no no no no no no Creatinine+blood 16:0/20:4-PC+blood 0.466165414 0 0 serum_choline serum_phospholipids 0.437 0.0262 no no no no up no Creatinine+blood 16:0/20:4-PI+blood -0.508270677 0 -0.435897436 serum_choline serum_phospholipids 0.437 0.558 no no no no no no Creatinine+blood 16:0/20:5-PC+blood 0 -0.534313725 0 serum_choline serum_phospholipids 0.437 0.628 no no no no no no Creatinine+blood 16:1/16:0-PC+blood 0.530827068 0 0 serum_choline serum_phospholipids 0.437 0.0215 no no no no up up Creatinine+blood 18:0/16:0-PC+blood 0.476691729 0 0 serum_choline serum_phospholipids 0.437 9.64E-07 no no no up up up Creatinine+blood 18:0/18:0-PE+blood -0.467669173 0 0 serum_choline serum_phospholipids 0.437 0.00896 no no no up up no Creatinine+blood 18:0/18:1-PE+blood -0.508270677 0 0 serum_choline serum_phospholipids 0.437 0.00716 no no no up up no Creatinine+blood 18:0/18:2-PI+blood 0 0 -0.407179487 serum_choline serum_phospholipids 0.437 0.179 no no no no no no Creatinine+blood 18:0/20:3-PI+blood 0.572932331 0 0 serum_choline serum_phospholipids 0.437 0.377 no no no no no no Creatinine+blood 18:0/20:4-PI+blood 0.472180451 0 0 serum_choline serum_phospholipids 0.437 0.167 no no no no no no Creatinine+blood 18:1-LPC+blood 0.590977444 0 0 serum_choline serum_phospholipids 0.437 0.179 no no no no no no Creatinine+blood 18:1/18:0-PS+blood 0 -0.522058824 0 serum_choline serum_phospholipids 0.437 0.193 no no no no no no Creatinine+blood 18:1/22:6-PE+blood 0 0 0.506324786 serum_choline serum_phospholipids 0.437 0.0047 no no no no up no Creatinine+blood 18:2-LPA+blood 0 0.654411765 0 serum_choline serum_phospholipids 0.437 0.00684 no no no dn no up Creatinine+blood 18:2/16:0-PC+blood 0.452631579 0 0 serum_choline serum_phospholipids 0.437 8.67E-05 no no no no up up Creatinine+blood 18:3/16:0-PE+blood -0.544360902 0 0 serum_choline serum_phospholipids 0.437 0.00149 no no no up up no Creatinine+blood 18:3n6+blood -0.714285714 0 0 serum_choline serum_fattyacid 0.437 0.0463 no no no up no dn Creatinine+blood 20:0+blood 0 -0.566176471 0 yes serum_choline serum_fattyacid 0.437 0.000278 no no no dn no up Creatinine+blood 20:1-LPA+blood 0 0.487745098 0 serum_choline serum_phospholipids 0.437 0.0187 no no no dn dn no Creatinine+blood 20:2+blood 0 0 0.42017094 serum_choline serum_fattyacid 0.437 0.478 no no no no no no Creatinine+blood 20:3/16:0-PC+blood 0.487218045 0 0 serum_choline serum_phospholipids 0.437 0.00405 no no no no up up Creatinine+blood 20:3/18:0-PI+blood 0.460150376 0 0 serum_choline serum_phospholipids 0.437 0.289 no no no no no no Creatinine+blood 20:5n3+blood 0 -0.556372549 0 serum_choline serum_fattyacid 0.437 0.988 no no no no no no Creatinine+blood 24:1+blood 0.488721805 0 0 serum_choline serum_fattyacid 0.437 0.00582 no no no no dn dn Creatinine+blood 5-HETE+blood 0 0.527365238 0 serum_choline serum_ARA 0.437 0.697 no no no no no no Creatinine+blood Betaine+blood 0.505263158 0 0 serum_choline serum_choline 0.437 0.857 no no no no no no Creatinine+blood Biosynthesis of cofactors -0.463157895 0 0 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood Blautia 0 0.634803922 0 acetate-producing serum_choline Genus 0.437 1.36E-05 no no no up dn dn Creatinine+blood Butyricimonas 0 -0.571426844 0 butyrate-producing serum_choline Genus 0.437 0.17 no no no no no no Creatinine+blood CDCA+blood -0.512781955 0 0 serum_choline serum_bileacids 0.437 0.506 no no no no no no Creatinine+blood cGMP-PKG signaling pathway 0.468421053 0 0 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood Choline+blood 0.717293233 0.62254902 0 serum_choline serum_choline 0.437 0.0395 no no no no up no Creatinine+blood Cocaine addiction 0 0 -0.443846154 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood Cortisol synthesis and secretion 0 0 -0.483076923 serum_choline kegg 0.437 NA no no no no no up Creatinine+blood Cushing syndrome 0 0 -0.49 serum_choline kegg 0.437 NA no no no no no up Creatinine+blood ErbB signaling pathway 0 0 -0.404615385 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood Fc epsilon RI signaling pathway 0.559649123 0 0 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood Fc gamma R-mediated phagocytosis 0 0 0.505384615 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood GCDCA+stool 0 0 -0.466165414 yes serum_choline stool_bileacids 0.437 0.0471 no no no no dn no Creatinine+blood Glucagon signaling pathway 0 0 -0.426923077 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood "Glycine, serine and threonine metabolism" -0.485964912 0 0 serum_choline kegg 0.437 NA no no no no up no Creatinine+blood Glycolysis / Gluconeogenesis -0.457894737 0 0 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood "Growth hormone synthesis, secretion and action" 0 0 -0.452307692 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood Insulin secretion 0 0 -0.417692308 yes serum_choline kegg 0.437 NA no no no no up up Creatinine+blood Legionellosis -0.563157895 0 0 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood Leishmaniasis -0.484210526 0 0 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood mRNA surveillance pathway 0 0 -0.400769231 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood Neuroactive ligand-receptor interaction 0 0 0.446923077 serum_choline kegg 0.437 NA no no no up up up Creatinine+blood Prolactin signaling pathway 0.49122807 0 0 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood Proteasome 0 0 0.455384615 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood Ras signaling pathway 0 -0.538235294 0 yes serum_choline kegg 0.437 NA no no no no up up Creatinine+blood RNA transport -0.531578947 0 0 serum_choline kegg 0.437 NA no no no no no no Creatinine+blood TCA+stool -0.643742012 0 0 serum_choline stool_bileacids 0.437 0.458 no no no no no no Cushing syndrome Adrenergic signaling in cardiomyocytes 0.612173913 0.682806324 0.812870013 kegg kegg NA NA no no up no no up Cushing syndrome "Alanine, aspartate and glutamate metabolism" -0.591304348 0 -0.444272844 kegg kegg NA NA no no up no no no Cushing syndrome Aldosterone synthesis and secretion 0.85826087 0.865612648 0.853281853 kegg kegg NA NA no no up no up up Cushing syndrome alpha-Linolenic acid metabolism -0.54173913 0 -0.573745174 kegg kegg NA NA no no up no no no Cushing syndrome Amino sugar and nucleotide sugar metabolism 0 0 -0.461518662 kegg kegg NA NA no no up no no no Cushing syndrome AMPK signaling pathway 0.506086957 0.735177866 0 kegg kegg NA NA no no up no no no Cushing syndrome Antifolate resistance 0 0.477272727 0 kegg kegg NA NA no no up no no no Cushing syndrome Antigen processing and presentation -0.594782609 -0.56916996 -0.461003861 kegg kegg NA NA no no up no no no Cushing syndrome Apoptosis -0.445217391 -0.515810277 -0.447104247 kegg kegg NA NA no no up no no no Cushing syndrome Arginine and proline metabolism -0.728695652 -0.424901186 0 kegg kegg NA NA no no up no up no Cushing syndrome Arginine biosynthesis -0.617391304 0 -0.447361647 kegg kegg NA NA no no up no no no Cushing syndrome Basal transcription factors 0 0.500988142 0 kegg kegg NA NA no no up no no no Cushing syndrome Base excision repair 0 0.476284585 0 kegg kegg NA NA no no up no no no Cushing syndrome beta-Alanine metabolism 0 0 -0.552123552 kegg kegg NA NA no no up no no no Cushing syndrome Biosynthesis of amino acids -0.563478261 -0.790513834 -0.685714286 kegg kegg NA NA no no up no no no Cushing syndrome Biosynthesis of cofactors 0 0.572134387 0 kegg kegg NA NA no no up no no no Cushing syndrome Blautia -0.469565217 0 0 acetate-producing kegg Genus NA 1.36E-05 no no up up dn dn Cushing syndrome Calcium signaling pathway 0.616521739 0.641304348 0.871814672 kegg kegg NA NA no no up no up up Cushing syndrome cAMP signaling pathway 0.419130435 0 0.636293436 yes kegg kegg NA NA no no up no up up Cushing syndrome Carbon metabolism -0.46 -0.792490119 -0.751093951 kegg kegg NA NA no no up no no no Cushing syndrome Cardiac muscle contraction 0.499130435 0.438735178 0 kegg kegg NA NA no no up no no up Cushing syndrome Cell adhesion molecules 0 -0.809288538 0 kegg kegg NA NA no no up no no no Cushing syndrome Cell cycle 0 0.599802372 0.456113256 kegg kegg NA NA no no up no no no Cushing syndrome Cellular senescence 0 -0.603754941 0 kegg kegg NA NA no no up no no no Cushing syndrome cGMP-PKG signaling pathway 0 -0.68972332 0 kegg kegg NA NA no no up no no no Cushing syndrome Chemokine signaling pathway 0 -0.438735178 0 kegg kegg NA NA no no up no no no Cushing syndrome Circadian entrainment 0.51826087 0 0.470527671 kegg kegg NA NA no no up no up up Cushing syndrome Circadian rhythm 0 0.760869565 0.533848134 kegg kegg NA NA no no up no no no Cushing syndrome Clostridium -0.434892182 -0.492083044 0 kegg Genus NA 0.925 no no up no no no Cushing syndrome Complement and coagulation cascades 0 -0.688735178 -0.437065637 kegg kegg NA NA no no up no no no Cushing syndrome Cortisol synthesis and secretion 0.880869565 0.949604743 0.874903475 kegg kegg NA NA no no up no no up Cushing syndrome Cytokine-cytokine receptor interaction 0 -0.470355731 0 kegg kegg NA NA no no up no no no Cushing syndrome Dopaminergic synapse 0.56173913 0.559288538 0.726640927 kegg kegg NA NA no no up no up no Cushing syndrome Drug metabolism - cytochrome P450 0 0 -0.472844273 kegg kegg NA NA no no up no no no Cushing syndrome Drug metabolism - other enzymes -0.43826087 0 -0.589189189 kegg kegg NA NA no no up no no no Cushing syndrome ECM-receptor interaction 0 0 0.521235521 kegg kegg NA NA no no up no up up Cushing syndrome Endocrine resistance 0.790434783 0.834980237 0.75006435 kegg kegg NA NA no no up no no no Cushing syndrome Endocytosis 0 -0.800395257 0 kegg kegg NA NA no no up no no no Cushing syndrome Ether lipid metabolism 0.440869565 0.568181818 0 kegg kegg NA NA no no up no no no Cushing syndrome Fanconi anemia pathway 0 0.449604743 0 kegg kegg NA NA no no up no no no Cushing syndrome Fatty acid biosynthesis -0.635652174 -0.434782609 0 kegg kegg NA NA no no up no no no Cushing syndrome Fatty acid degradation -0.688695652 -0.441699605 -0.713513514 kegg kegg NA NA no no up no no no Cushing syndrome Fatty acid elongation 0 -0.508893281 -0.445045045 kegg kegg NA NA no no up no no no Cushing syndrome Fatty acid metabolism -0.719130435 -0.555335968 -0.697039897 kegg kegg NA NA no no up no no no Cushing syndrome Fc epsilon RI signaling pathway 0 -0.472332016 0 kegg kegg NA NA no no up no no no Cushing syndrome Fc gamma R-mediated phagocytosis -0.65826087 -0.83201581 -0.567567568 kegg kegg NA NA no no up no no no Cushing syndrome Fructose and mannose metabolism 0 0 -0.581724582 kegg kegg NA NA no no up no no no Cushing syndrome GABAergic synapse -0.472173913 0 0 kegg kegg NA NA no no up no up up Cushing syndrome Galactose metabolism -0.468695652 0 -0.478249678 kegg kegg NA NA no no up no no no Cushing syndrome Gap junction 0.673043478 0.542490119 0.405662806 kegg kegg NA NA no no up no no no Cushing syndrome Glucagon signaling pathway 0.785217391 0.789525692 0.821879022 kegg kegg NA NA no no up no no no Cushing syndrome Glutamatergic synapse 0.443478261 0 0 kegg kegg NA NA no no up no up up Cushing syndrome Glutathione metabolism 0 0.505928854 0 kegg kegg NA NA no no up no no no Cushing syndrome Glycerophospholipid metabolism 0 0.444664032 0 kegg kegg NA NA no no up no no up Cushing syndrome "Glycine, serine and threonine metabolism" 0 0.581027668 0 kegg kegg NA NA no no up no up no Cushing syndrome Glycolysis / Gluconeogenesis 0 0 -0.54028314 kegg kegg NA NA no no up no no no Cushing syndrome Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.42 0 0 kegg kegg NA NA no no up no no no Cushing syndrome Glycosaminoglycan biosynthesis - keratan sulfate 0.546956522 0 0.496267696 kegg kegg NA NA no no up no no no Cushing syndrome Glycosaminoglycan degradation 0 -0.661067194 -0.431917632 kegg kegg NA NA no no up no no up Cushing syndrome Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.605731225 0 kegg kegg NA NA no no up no no no Cushing syndrome Glyoxylate and dicarboxylate metabolism -0.719130435 -0.442687747 -0.503732304 kegg kegg NA NA no no up no no no Cushing syndrome GnRH signaling pathway 0.764347826 0.880434783 0.768597169 kegg kegg NA NA no no up no no no Cushing syndrome Hedgehog signaling pathway 0.512173913 0.470355731 0 kegg kegg NA NA no no up no no no Cushing syndrome Hippo signaling pathway - multiple species -0.546086957 0 0 kegg kegg NA NA no no up no no no Cushing syndrome Histidine metabolism -0.422608696 0 -0.575289575 kegg kegg NA NA no no up no no no Cushing syndrome IL-17 signaling pathway -0.542608696 -0.679841897 -0.482882883 kegg kegg NA NA no no up no no no Cushing syndrome Inflammatory mediator regulation of TRP channels 0.7 0.60770751 0.814414414 kegg kegg NA NA no no up no no no Cushing syndrome Insulin secretion 0.893913043 0.93972332 0.862548263 yes kegg kegg NA NA no no up no up up Cushing syndrome Leukocyte transendothelial migration 0 -0.515810277 0 kegg kegg NA NA no no up no no no Cushing syndrome Long-term depression 0.727826087 0.501976285 0.642213642 kegg kegg NA NA no no up no no no Cushing syndrome Longevity regulating pathway 0.474782609 0.516798419 0 kegg kegg NA NA no no up no no no Cushing syndrome Longevity regulating pathway - multiple species 0 -0.631422925 0 kegg kegg NA NA no no up no no no Cushing syndrome Lysine degradation 0 0.605731225 0 kegg kegg NA NA no no up no no no Cushing syndrome Lysosome -0.517391304 -0.833003953 -0.638867439 kegg kegg NA NA no no up no no no Cushing syndrome Mannose type O-glycan biosynthesis 0.409565217 0.53458498 0 kegg kegg NA NA no no up no no no Cushing syndrome Melanogenesis 0.853043478 0.64229249 0.837580438 kegg kegg NA NA no no up no no no Cushing syndrome Metabolism of xenobiotics by cytochrome P450 0 0 -0.507593308 kegg kegg NA NA no no up no no no Cushing syndrome Mitophagy - animal 0.572173913 0.600790514 0 kegg kegg NA NA no no up no no no Cushing syndrome mRNA surveillance pathway 0.429565217 0.679841897 0.581981982 kegg kegg NA NA no no up no no no Cushing syndrome N-Glycan biosynthesis 0 0.416007905 0.409009009 kegg kegg NA NA no no up no no no Cushing syndrome Natural killer cell mediated cytotoxicity 0 -0.707509881 0 kegg kegg NA NA no no up no no no Cushing syndrome Necroptosis 0.506956522 0.414031621 0 kegg kegg NA NA no no up no no no Cushing syndrome Neuroactive ligand-receptor interaction -0.563478261 -0.864624506 -0.558043758 kegg kegg NA NA no no up up up up Cushing syndrome Neutrophil extracellular trap formation -0.593043478 -0.792490119 -0.578378378 kegg kegg NA NA no no up no no no Cushing syndrome NF-kappa B signaling pathway -0.414782609 0 0 kegg kegg NA NA no no up no no no Cushing syndrome Nicotinate and nicotinamide metabolism -0.706956522 -0.469367589 -0.470785071 kegg kegg NA NA no no up no no no Cushing syndrome Nitrogen metabolism -0.480869565 0 0 kegg kegg NA NA no no up no no no Cushing syndrome NOD-like receptor signaling pathway -0.73826087 -0.463438735 0 kegg kegg NA NA no no up no no no Cushing syndrome Non-alcoholic fatty liver disease 0.505217391 0.4743083 0 kegg kegg NA NA no no up no no no Cushing syndrome Odoribacter -0.495657053 -0.576524799 0 butyrate-producing kegg Genus NA 0.798 no no up no no no Cushing syndrome Olfactory transduction -0.475652174 -0.711462451 -0.688545689 kegg kegg NA NA no no up no no no Cushing syndrome Osteoclast differentiation -0.682608696 -0.662055336 0 kegg kegg NA NA no no up no no no Cushing syndrome Other glycan degradation -0.434782609 0 0 kegg kegg NA NA no no up no no no Cushing syndrome Other types of O-glycan biosynthesis 0 0.721343874 0 kegg kegg NA NA no no up no no no Cushing syndrome Ovarian steroidogenesis 0.737391304 0.66798419 0.474646075 kegg kegg NA NA no no up no up up Cushing syndrome Oxidative phosphorylation 0.426086957 0.421936759 0 kegg kegg NA NA no no up no no no Cushing syndrome p53 signaling pathway 0 0.518774704 0 kegg kegg NA NA no no up no no no Cushing syndrome Pantothenate and CoA biosynthesis -0.564347826 -0.576086957 -0.663577864 kegg kegg NA NA no no up no no dn Cushing syndrome "Parathyroid hormone synthesis, secretion and action" 0.593043478 0.627470356 0.593822394 kegg kegg NA NA no no up no no no Cushing syndrome Pentose phosphate pathway -0.44 -0.827075099 -0.662805663 kegg kegg NA NA no no up no no no Cushing syndrome Peroxisome -0.766956522 -0.579051383 -0.488803089 kegg kegg NA NA no no up no no no Cushing syndrome Phagosome 0 -0.848814229 -0.475675676 kegg kegg NA NA no no up no no no Cushing syndrome Phosphatidylinositol signaling system 0.422608696 0 0 kegg kegg NA NA no no up no no no Cushing syndrome Phospholipase D signaling pathway 0 0 0.433719434 kegg kegg NA NA no no up no up up Cushing syndrome Porphyrin and chlorophyll metabolism 0 0.518774704 0 kegg kegg NA NA no no up no no no Cushing syndrome PPAR signaling pathway -0.60173913 -0.543478261 0 kegg kegg NA NA no no up no no no Cushing syndrome Prevotella 0 0 0.553025813 acetate-producing kegg Genus NA 0.287 no no up no no no Cushing syndrome Primary bile acid biosynthesis 0 0 -0.447876448 kegg kegg NA NA no no up no no no Cushing syndrome Proteasome -0.460869565 0 -0.525096525 kegg kegg NA NA no no up no no no Cushing syndrome Protein processing in endoplasmic reticulum 0.491304348 0.528656126 0 kegg kegg NA NA no no up no no no Cushing syndrome Purine metabolism 0 0.625494071 0 kegg kegg NA NA no no up no no no Cushing syndrome Pyrimidine metabolism -0.433043478 0 0 kegg kegg NA NA no no up no no no Cushing syndrome Regulation of lipolysis in adipocytes 0.708695652 0.708498024 0.644530245 kegg kegg NA NA no no up no no no Cushing syndrome Relaxin signaling pathway 0 0 0.543114543 kegg kegg NA NA no no up no no no Cushing syndrome Renin secretion 0.626956522 0.467391304 0.55984556 kegg kegg NA NA no no up no no no Cushing syndrome Renin-angiotensin system -0.508695652 -0.778656126 -0.462805663 kegg kegg NA NA no no up no no no Cushing syndrome Ribosome 0.506956522 0 0 kegg kegg NA NA no no up no no no Cushing syndrome Ribosome biogenesis in eukaryotes 0 0.526679842 0 kegg kegg NA NA no no up no no no Cushing syndrome RNA degradation 0 0.537549407 0 kegg kegg NA NA no no up no no no Cushing syndrome RNA polymerase 0 0.606719368 0 kegg kegg NA NA no no up no no no Cushing syndrome Selenocompound metabolism 0 0.440711462 0 kegg kegg NA NA no no up no no no Cushing syndrome Signaling pathways regulating pluripotency of stem cells 0.462608696 0.548418972 0.492149292 kegg kegg NA NA no no up no no no Cushing syndrome Sphingolipid metabolism 0 0 -0.444015444 kegg kegg NA NA no no up no no no Cushing syndrome Sphingolipid signaling pathway 0 -0.54743083 0 kegg kegg NA NA no no up no no no Cushing syndrome Spliceosome 0 0.443675889 0.439382239 kegg kegg NA NA no no up no no no Cushing syndrome Starch and sucrose metabolism -0.606086957 -0.468379447 -0.689317889 kegg kegg NA NA no no up no no no Cushing syndrome Synaptic vesicle cycle -0.453043478 -0.7756917 -0.698841699 kegg kegg NA NA no no up no up up Cushing syndrome Taurine and hypotaurine metabolism 0 0.469367589 0 kegg kegg NA NA no no up no no no Cushing syndrome Thermogenesis 0.537391304 0.43972332 0 kegg kegg NA NA no no up no no no Cushing syndrome Thyroid hormone synthesis 0.722608696 0.824110672 0.404375804 kegg kegg NA NA no no up no no no Cushing syndrome Tight junction 0 0 -0.502187902 kegg kegg NA NA no no up no no no Cushing syndrome Tryptophan metabolism 0 0 -0.445817246 kegg kegg NA NA no no up no up no Cushing syndrome Ubiquitin mediated proteolysis 0.649565217 0.668972332 0 kegg kegg NA NA no no up no no no Cushing syndrome Vascular smooth muscle contraction 0.602608696 0 0.401029601 kegg kegg NA NA no no up no no no Cushing syndrome Wnt signaling pathway 0.542608696 0.52173913 0 kegg kegg NA NA no no up no no no Cysteine and methionine metabolism "Alanine, aspartate and glutamate metabolism" 0 -0.615612648 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Arginine biosynthesis 0 -0.608695652 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Citrate cycle (TCA cycle) 0.689565217 0.889328063 0.538223938 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Fatty acid biosynthesis 0 -0.598814229 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Fatty acid elongation 0 0.691699605 0.611325611 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Fructose and mannose metabolism 0 -0.571146245 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Glycolysis / Gluconeogenesis 0.58173913 0.831027668 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Oxidative phosphorylation 0 0.46541502 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Pentose and glucuronate interconversions 0.73826087 0.817193676 0.566023166 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Pentose phosphate pathway 0 -0.425889328 -0.489317889 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Primary bile acid biosynthesis 0.686956522 0.714426877 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Pyrimidine metabolism 0.406086957 0.563241107 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Steroid biosynthesis 0 0.72826087 0.552638353 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Steroid hormone biosynthesis 0.546956522 0.652173913 0 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Synthesis and degradation of ketone bodies 0.813043478 0.739130435 0.582239382 kegg kegg NA NA no no no no no no Cysteine and methionine metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.599130435 0.695652174 0.577863578 kegg kegg NA NA no no no no no no Cysteine+blood 14:0/20:4-PC+blood 0 0 -0.492649573 yes serum_aminoacids serum_phospholipids 1.81E-07 0.486 dn up up no no no Cysteine+blood 14:1/18:2-PG+blood 0 0.571078431 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.00259 dn up up no up up Cysteine+blood 16:0-LPE+blood -0.497744361 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.0711 dn up up up up no Cysteine+blood 16:0/18:0-PS+blood -0.461654135 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.377 dn up up no no no Cysteine+blood 16:0/18:1-PC+blood 0 0 0.540512821 yes serum_aminoacids serum_phospholipids 1.81E-07 6.15E-07 dn up up up up up Cysteine+blood 16:0/18:2-PC+blood 0 0 0.513846154 yes serum_aminoacids serum_phospholipids 1.81E-07 3.24E-06 dn up up no up up Cysteine+blood 16:0/20:3-PC+blood 0.545864662 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 5.43E-06 dn up up no up up Cysteine+blood 16:0/20:4-PC+blood 0.470676692 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.0262 dn up up no up no Cysteine+blood 16:0/20:4-PE+blood -0.562406015 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.00139 dn up up up up no Cysteine+blood 16:1/16:0-PC+blood 0 0 0.457777778 yes serum_aminoacids serum_phospholipids 1.81E-07 0.0215 dn up up no up up Cysteine+blood 18:0-LPA+blood 0 0.544117647 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.0725 dn up up no dn no Cysteine+blood 18:0-LPE+blood -0.538345865 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.491 dn up up no no no Cysteine+blood 18:0/16:0-PC+blood 0 0 0.494017094 yes serum_aminoacids serum_phospholipids 1.81E-07 9.64E-07 dn up up up up up Cysteine+blood 18:0/18:0-PE+blood -0.49924812 0 -0.411282051 yes serum_aminoacids serum_phospholipids 1.81E-07 0.00896 dn up up up up no Cysteine+blood 18:0/18:1-PE+blood -0.530827068 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.00716 dn up up up up no Cysteine+blood 18:0/18:2-PC+blood 0 0 0.40991453 yes serum_aminoacids serum_phospholipids 1.81E-07 1.74E-06 dn up up no up up Cysteine+blood 18:0/20:4-PC+blood 0.466165414 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.454 dn up up no no no Cysteine+blood 18:1-LPE+blood -0.497744361 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.117 dn up up no no no Cysteine+blood 18:1/16:0-PC+blood 0 0 0.509059829 yes serum_aminoacids serum_phospholipids 1.81E-07 2.43E-05 dn up up no up up Cysteine+blood 18:1/16:0-PE+blood -0.586466165 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.000182 dn up up up up no Cysteine+blood 18:1/16:1-PE+blood -0.458646617 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.000184 dn up up up up no Cysteine+blood 18:1/18:0-PE+blood -0.484210526 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 1.39E-06 dn up up up up no Cysteine+blood 18:1/18:2-PE+blood 0 0 -0.404444444 yes serum_aminoacids serum_phospholipids 1.81E-07 0.000293 dn up up up up no Cysteine+blood 18:1/18:2-PI+blood 0.518796992 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.0164 dn up up dn no up Cysteine+blood 18:1/20:3-PC+blood 0.491729323 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.00872 dn up up no up up Cysteine+blood 18:1/20:4-PI+blood 0.610526316 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.192 dn up up no no no Cysteine+blood 18:1+blood 0 0 0.47965812 yes yes serum_aminoacids serum_fattyacid 1.81E-07 0.00202 dn up up up no dn Cysteine+blood 18:2/18:2-PS+blood -0.536842105 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.00674 dn up up up up no Cysteine+blood 18:3-LPC+blood 0 -0.524509804 -0.414017094 yes serum_aminoacids serum_phospholipids 1.81E-07 0.147 dn up up no no no Cysteine+blood 18:3/16:0-PE+blood -0.523308271 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.00149 dn up up up up no Cysteine+blood 20:1-LPA+blood 0.44962406 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.0187 dn up up dn dn no Cysteine+blood 20:2-LPC+blood 0.467669173 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.119 dn up up no no up Cysteine+blood 20:2+blood 0 0.593137255 0.465982906 yes serum_aminoacids serum_fattyacid 1.81E-07 0.478 dn up up no no no Cysteine+blood 20:4/16:0-PE+blood 0 0 -0.588376068 yes serum_aminoacids serum_phospholipids 1.81E-07 0.00529 dn up up no up up Cysteine+blood 20:5-LPC+blood 0 -0.568627451 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.558 dn up up no no no Cysteine+blood 20:5/18:0-PC+blood 0.497744361 0 0 yes serum_aminoacids serum_phospholipids 1.81E-07 3.97E-06 dn up up no up up Cysteine+blood 22:1-LPA+blood 0 0.580882353 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.00373 dn up up no up up Cysteine+blood 22:2-LPA+blood 0 0.644607843 0 yes serum_aminoacids serum_phospholipids 1.81E-07 0.0443 dn up up dn no no Cysteine+blood 4-hydroxybenzoic acid+stool 0.648351648 0 0 yes serum_aminoacids stool_cometabolism 1.81E-07 0.0536 dn up up no dn no Cysteine+blood 9-HODE+blood 0.454135338 0 0 yes serum_aminoacids serum_ARA 1.81E-07 0.297 dn up up no no no Cysteine+blood Acetic acid+stool 0 0 -0.45112782 yes yes serum_aminoacids stool_scfa 1.81E-07 0.0656 dn up up dn no no Cysteine+blood Acute myeloid leukemia 0 0.508823529 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Adrenergic signaling in cardiomyocytes 0 -0.623529412 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no up Cysteine+blood AGE-RAGE signaling pathway in diabetic complications 0 0.538235294 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Alcoholism 0 0.638235294 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Aldosterone synthesis and secretion 0 -0.635294118 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no up up Cysteine+blood Allograft rejection 0 0.588235294 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Alzheimer disease 0 0 -0.401538462 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Amoebiasis 0 0.608823529 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Amphetamine addiction 0 -0.591176471 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Amyotrophic lateral sclerosis 0 0 -0.528461538 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Apelin signaling pathway 0 -0.605882353 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Apoptosis 0 0.541176471 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Arginine and proline metabolism 0 0 0.623076923 yes serum_aminoacids kegg 1.81E-07 NA dn up up no up no Cysteine+blood Autoimmune thyroid disease 0 0.588235294 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Biosynthesis of amino acids 0 0.794117647 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Bladder cancer 0 0.505882353 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood CA+blood 0 -0.556713777 -0.565011901 yes serum_aminoacids serum_bileacids 1.81E-07 0.606 dn up up no no no Cysteine+blood Calcium signaling pathway 0 0 -0.401538462 yes serum_aminoacids kegg 1.81E-07 NA dn up up no up up Cysteine+blood Cardiac muscle contraction 0 0 -0.46 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no up Cysteine+blood CDCA+blood 0 -0.529411765 -0.503589744 yes serum_aminoacids serum_bileacids 1.81E-07 0.506 dn up up no no no Cysteine+blood Cell adhesion molecules 0 0.576470588 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Cell cycle 0 -0.811764706 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Cellular senescence 0 0.629411765 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood cGMP-PKG signaling pathway 0 0.814705882 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Chemical carcinogenesis - receptor activation 0 -0.523529412 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Chemokine signaling pathway 0 0.620588235 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Clostridium 0 0.497854171 0 yes serum_aminoacids Genus 1.81E-07 0.925 dn up up no no no Cysteine+blood Creatinine+blood 0.446616541 0 0.490598291 yes serum_aminoacids serum_choline 1.81E-07 0.437 dn up up no no no Cysteine+blood Cushing syndrome 0 -0.65 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no up Cysteine+blood Cytokine-cytokine receptor interaction 0 0.638235294 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood EGFR tyrosine kinase inhibitor resistance 0 -0.620588235 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Endocytosis 0 0.664705882 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Epithelial cell signaling in Helicobacter pylori infection 0 0.552941176 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Faecalibacterium 0 0 -0.441442988 yes butyrate-producing serum_aminoacids Genus 1.81E-07 0.0039 dn up up no dn dn Cysteine+blood Fc epsilon RI signaling pathway 0 0.561764706 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Fc gamma R-mediated phagocytosis 0 0.744117647 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Gemmiger -0.45112782 0 0 yes butyrate-producing serum_aminoacids Genus 1.81E-07 0.595 dn up up no no no Cysteine+blood Glucagon signaling pathway 0 -0.629411765 -0.428461538 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Graft-versus-host disease 0 0.588235294 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood HCA+stool 0 0 -0.45112782 yes serum_aminoacids stool_bileacids 1.81E-07 0.155 dn up up no no no Cysteine+blood HDCA+stool 0 -0.636363636 0 yes serum_aminoacids stool_bileacids 1.81E-07 0.176 dn up up no no no Cysteine+blood Hippo signaling pathway 0 0 -0.431538462 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Human papillomavirus infection 0 0.602941176 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Huntington disease 0 0 -0.407692308 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood IL-17 signaling pathway 0 0.823529412 0.44 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Influenza A 0 0.529411765 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Insulin signaling pathway 0 -0.605882353 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood L-Phenylalanine+stool 0 0 0.44962406 yes serum_aminoacids stool_cometabolism 1.81E-07 0.398 dn up up no no no Cysteine+blood Lipid and atherosclerosis 0 0.708823529 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Long-term potentiation 0 -0.576470588 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no up Cysteine+blood Lysosome 0 0.841176471 0.435384615 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Measles 0 -0.508823529 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood mRNA surveillance pathway 0 -0.808823529 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood mTOR signaling pathway 0 -0.658823529 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Natural killer cell mediated cytotoxicity 0 0.611764706 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Neuroactive ligand-receptor interaction 0 0.8 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up up up up Cysteine+blood Neutrophil extracellular trap formation 0 0.814705882 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Nicotinate and nicotinamide metabolism 0 0.591176471 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Non-alcoholic fatty liver disease 0 0 -0.483846154 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Olfactory transduction 0 0.752941176 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Osteoclast differentiation 0 0.641176471 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Oxytocin signaling pathway 0 0.529411765 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Pathogenic Escherichia coli infection 0 0.667647059 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Peroxisome 0 0.623529412 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Pertussis 0 0.852941176 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no dn Cysteine+blood Phagosome 0 0.711764706 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Phenylacetic acid+stool 0 0 0.57443609 yes serum_aminoacids stool_cometabolism 1.81E-07 0.785 dn up up no no no Cysteine+blood PI3K-Akt signaling pathway 0 -0.635294118 0 yes yes serum_aminoacids kegg 1.81E-07 NA dn up up no up up Cysteine+blood Primary immunodeficiency 0 -0.614705882 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Prion disease 0 0 -0.413076923 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Progesterone-mediated oocyte maturation 0 -0.567647059 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Prolactin signaling pathway 0 0.538235294 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Proteasome 0 0 0.462307692 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Protein processing in endoplasmic reticulum 0 -0.744117647 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Proteoglycans in cancer 0 -0.502941176 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Rheumatoid arthritis 0 0.735294118 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Ribosome biogenesis in eukaryotes 0 -0.770588235 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood RNA degradation 0 -0.652941176 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood RNA transport 0 -0.6 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Slackia 0 0 -0.405914191 yes serum_aminoacids Genus 1.81E-07 0.94 dn up up no no no Cysteine+blood Spinocerebellar ataxia 0 -0.711764706 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Spliceosome 0 -0.602941176 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Staphylococcus aureus infection 0 0.717647059 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up up no no Cysteine+blood Systemic lupus erythematosus 0 0.794117647 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Tuberculosis 0 0.75 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no dn Cysteine+blood Type I diabetes mellitus 0 0.588235294 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Ubiquitin mediated proteolysis 0 -0.505882353 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Viral carcinogenesis 0 0.541176471 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Viral myocarditis 0 0.538235294 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Viral protein interaction with cytokine and cytokine receptor 0 0.752941176 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Wnt signaling pathway 0 -0.697058824 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cysteine+blood Yersinia infection 0 0.685294118 0 yes serum_aminoacids kegg 1.81E-07 NA dn up up no no no Cystine+blood 12-HEPE+blood 0 -0.507149988 0 yes serum_aminoacids serum_ARA 0.00028 0.312 up up no no no no Cystine+blood 12-ketoDCA+stool -0.582417582 0 0 yes serum_aminoacids stool_bileacids 0.00028 0.505 up up no no no no Cystine+blood 14:0/18:2-PC+blood -0.482706767 0 -0.461880342 yes serum_aminoacids serum_phospholipids 0.00028 0.102 up up no no up no Cystine+blood 14:0/20:4-PC+blood 0 0 -0.405811966 yes serum_aminoacids serum_phospholipids 0.00028 0.486 up up no no no no Cystine+blood 15-HETE+blood 0.513651104 0 0 yes serum_aminoacids serum_ARA 0.00028 0.819 up up no no no no Cystine+blood 16:0/18:0-PS+blood -0.464661654 0 0 yes serum_aminoacids serum_phospholipids 0.00028 0.377 up up no no no no Cystine+blood 16:0/18:1-PC+blood 0 0 0.456410256 yes serum_aminoacids serum_phospholipids 0.00028 6.15E-07 up up no up up up Cystine+blood 16:0/18:1-PE+blood -0.445112782 0 0 yes serum_aminoacids serum_phospholipids 0.00028 0.000107 up up no up up no Cystine+blood 16:0/18:2-PC+blood 0 0.642156863 0 yes serum_aminoacids serum_phospholipids 0.00028 3.24E-06 up up no no up up Cystine+blood 16:0/20:4-PI+blood 0 -0.50245098 0 yes serum_aminoacids serum_phospholipids 0.00028 0.558 up up no no no no Cystine+blood 16:0/20:5-PC+blood 0 -0.642156863 0 yes serum_aminoacids serum_phospholipids 0.00028 0.628 up up no no no no Cystine+blood 18:0-LPC+blood -0.472180451 0 0 yes serum_aminoacids serum_phospholipids 0.00028 0.554 up up no no no no Cystine+blood 18:0-LPE+blood -0.472180451 0 0 yes serum_aminoacids serum_phospholipids 0.00028 0.491 up up no no no no Cystine+blood 18:0/16:0-PC+blood 0 0.49754902 0.439316239 yes serum_aminoacids serum_phospholipids 0.00028 9.64E-07 up up no up up up Cystine+blood 18:0/18:0-PE+blood 0 0 -0.543247863 yes serum_aminoacids serum_phospholipids 0.00028 0.00896 up up no up up no Cystine+blood 18:0/18:1-PE+blood 0 0 -0.442735043 yes serum_aminoacids serum_phospholipids 0.00028 0.00716 up up no up up no Cystine+blood 18:0/18:1-PI+blood -0.452631579 0 0 yes serum_aminoacids serum_phospholipids 0.00028 0.599 up up no no no no Cystine+blood 18:0/18:2-PI+blood -0.44962406 0 0 yes serum_aminoacids serum_phospholipids 0.00028 0.179 up up no no no no Cystine+blood 18:0/20:5-PC+blood 0.497744361 0 0 yes serum_aminoacids serum_phospholipids 0.00028 0.17 up up no no no no Cystine+blood 18:1/16:0-PC+blood 0 0.642156863 0 yes serum_aminoacids serum_phospholipids 0.00028 2.43E-05 up up no no up up Cystine+blood 18:1/16:0-PE+blood -0.509774436 0 -0.451623932 yes serum_aminoacids serum_phospholipids 0.00028 0.000182 up up no up up no Cystine+blood 18:1/16:0-PI+blood -0.541353383 0 0 yes serum_aminoacids serum_phospholipids 0.00028 0.793 up up no no no no Cystine+blood 18:1/16:1-PE+blood -0.484210526 0 0 yes serum_aminoacids serum_phospholipids 0.00028 0.000184 up up no up up no Cystine+blood 18:1/18:0-PE+blood -0.44962406 0 0 yes serum_aminoacids serum_phospholipids 0.00028 1.39E-06 up up no up up no Cystine+blood 18:1/18:1-PE+blood -0.556390977 0 0 yes serum_aminoacids serum_phospholipids 0.00028 1.03E-05 up up no up up no Cystine+blood 18:1/18:1-PG+blood 0 0 0.540512821 yes serum_aminoacids serum_phospholipids 0.00028 0.00352 up up no no up up Cystine+blood 18:1/18:2-PI+blood 0 0 -0.401025641 yes serum_aminoacids serum_phospholipids 0.00028 0.0164 up up no dn no up Cystine+blood 18:2/18:2-PS+blood -0.503759398 0 0 yes serum_aminoacids serum_phospholipids 0.00028 0.00674 up up no up up no Cystine+blood 18:3/16:0-PE+blood -0.45112782 0 0 yes serum_aminoacids serum_phospholipids 0.00028 0.00149 up up no up up no Cystine+blood 18:3/18:2-PC+blood 0 -0.546568627 0 yes serum_aminoacids serum_phospholipids 0.00028 0.0394 up up no no no up Cystine+blood 20:0/20:4-PE+blood 0 0 -0.424957265 yes serum_aminoacids serum_phospholipids 0.00028 0.00128 up up no up up no Cystine+blood 20:2/18:1-PE+blood -0.538345865 0 0 yes serum_aminoacids serum_phospholipids 0.00028 0.00208 up up no up up no Cystine+blood 20:4/16:0-PE+blood 0 0 -0.612307692 yes serum_aminoacids serum_phospholipids 0.00028 0.00529 up up no no up up Cystine+blood 24:1+blood 0.485714286 0 0.406495726 yes serum_aminoacids serum_fattyacid 0.00028 0.00582 up up no no dn dn Cystine+blood Acute myeloid leukemia 0.512280702 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood AGE-RAGE signaling pathway in diabetic complications 0.492982456 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Allograft rejection 0.547368421 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Amoebiasis 0.478947368 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood AMPK signaling pathway 0 0 -0.502307692 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Arginine and proline metabolism 0 0 0.523076923 yes serum_aminoacids kegg 0.00028 NA up up no no up no Cystine+blood Asthma 0.5 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Autoimmune thyroid disease 0.547368421 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Blautia 0 0.580882353 0 yes acetate-producing serum_aminoacids Genus 0.00028 1.36E-05 up up no up dn dn Cystine+blood butyric acid C4+blood 0.494736842 0 0 yes serum_aminoacids serum_scfa 0.00028 0.407 up up no no no no Cystine+blood capric acid C6+blood -0.464661654 0 0 yes serum_aminoacids serum_scfa 0.00028 0.433 up up no no no no Cystine+blood Cell cycle -0.778947368 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Cellular senescence 0.549122807 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Creatinine+blood 0 0.590686275 0 yes serum_aminoacids serum_choline 0.00028 0.437 up up no no no no Cystine+blood Cysteine+blood 0 0 0.597948718 yes yes serum_aminoacids serum_aminoacids 0.00028 1.81E-07 up up no dn up up Cystine+blood DCA+stool 0 0 -0.457142857 yes serum_aminoacids stool_bileacids 0.00028 0.195 up up no no no no Cystine+blood Endocrine resistance 0 0 -0.415384615 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Endocytosis 0.51754386 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Estrogen signaling pathway -0.557894737 0 -0.564615385 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Ferroptosis 0.545614035 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Gap junction 0 0 -0.406923077 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood GCDCA+stool 0 0.636363636 0 yes yes serum_aminoacids stool_bileacids 0.00028 0.0471 up up no no dn no Cystine+blood Graft-versus-host disease 0.519298246 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Human papillomavirus infection 0.587719298 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Influenza A 0.675438596 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood LCA+stool 0 0 -0.482706767 yes serum_aminoacids stool_bileacids 0.00028 0.314 up up no no no no Cystine+blood Legionellosis -0.531578947 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Longevity regulating pathway 0 0 -0.412307692 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Lysosome 0.521052632 0 0.463846154 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Malaria 0.496491228 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Methanobrevibacter 0 -0.516353281 0 yes serum_aminoacids Genus 0.00028 0.629 up up no no no no Cystine+blood Oocyte meiosis -0.510526316 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Pancreatic cancer 0 0 -0.449230769 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Phagosome 0.521052632 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Phenylacetic acid+stool 0 -0.609090909 0 yes serum_aminoacids stool_cometabolism 0.00028 0.785 up up no no no no Cystine+blood Phospholipase D signaling pathway 0.461403509 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no up up Cystine+blood PI3K-Akt signaling pathway -0.554385965 0 0 yes yes serum_aminoacids kegg 0.00028 NA up up no no up up Cystine+blood Primary immunodeficiency -0.533333333 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Progesterone-mediated oocyte maturation -0.478947368 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Proteasome 0 0 0.435384615 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Rheumatoid arthritis 0.473684211 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Ribosome biogenesis in eukaryotes -0.571929825 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood RNA transport -0.668421053 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Slackia 0 0 -0.553971019 yes serum_aminoacids Genus 0.00028 0.94 up up no no no no Cystine+blood Spliceosome -0.571929825 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood T cell receptor signaling pathway -0.473684211 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Type I diabetes mellitus 0.547368421 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Viral carcinogenesis 0.538596491 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cystine+blood Viral myocarditis 0.542105263 0 0 yes serum_aminoacids kegg 0.00028 NA up up no no no no Cytokine-cytokine receptor interaction Akkermansia 0 -0.522639678 0 acetate-producing kegg Genus NA 0.23 no no no no no no Cytokine-cytokine receptor interaction alpha-Linolenic acid metabolism 0 0.46541502 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Arachidonic acid metabolism 0 0.433794466 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Bacteroides 0 0 0.402574003 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Cytokine-cytokine receptor interaction Biosynthesis of amino acids 0 0.505928854 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Biosynthesis of unsaturated fatty acids 0 0.548418972 0.424195624 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction cGMP-PKG signaling pathway 0 0.543478261 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Fatty acid biosynthesis 0 0.468379447 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Fatty acid elongation 0 0.470355731 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Fatty acid metabolism 0 0.550395257 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Folate biosynthesis 0 -0.517786561 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Glutathione metabolism -0.406086957 0 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Glycosaminoglycan biosynthesis - keratan sulfate 0 -0.532608696 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Glycosphingolipid biosynthesis - ganglio series -0.408695652 0 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Lysine degradation 0 -0.546442688 -0.455083655 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Mannose type O-glycan biosynthesis 0 -0.613636364 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction mRNA surveillance pathway 0 -0.720355731 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Nicotinate and nicotinamide metabolism 0 0.451581028 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Other types of O-glycan biosynthesis 0 -0.418972332 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Oxidative phosphorylation 0 -0.418972332 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Pantothenate and CoA biosynthesis 0.443478261 0.551383399 0 kegg kegg NA NA no no no no no dn Cytokine-cytokine receptor interaction Pentose phosphate pathway 0 0.586956522 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Protein export 0 -0.460474308 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Rap1 signaling pathway 0 0 0.563963964 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction RNA degradation 0 -0.531620553 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction RNA polymerase 0 -0.419960474 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Sulfur metabolism -0.442608696 0 0 kegg kegg NA NA no no no no no no Cytokine-cytokine receptor interaction Tyrosine metabolism 0 0 0.431145431 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Amino sugar and nucleotide sugar metabolism 0 -0.454545455 -0.626512227 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Aminoacyl-tRNA biosynthesis 0 -0.437747036 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Antifolate resistance 0 -0.48715415 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Apoptosis 0.433043478 0.508893281 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Apoptosis - multiple species -0.509565217 0 -0.662033462 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Autophagy - animal 0 0.517786561 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Autophagy - other 0 0.423913043 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Base excision repair 0 0 -0.527927928 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway beta-Alanine metabolism 0 -0.636363636 -0.59047619 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Biosynthesis of unsaturated fatty acids 0 -0.613636364 -0.571943372 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Butanoate metabolism 0 -0.576086957 -0.435263835 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway cAMP signaling pathway 0 0.796442688 0.598198198 yes kegg kegg NA NA no no no no up up Cytosolic DNA-sensing pathway Cellular senescence 0 0.444664032 0.608751609 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Chemokine signaling pathway 0.529565217 0 0.584298584 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Citrate cycle (TCA cycle) 0 -0.550395257 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Cysteine and methionine metabolism 0 -0.544466403 -0.429343629 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Cytokine-cytokine receptor interaction 0 -0.414031621 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway DNA replication -0.419130435 -0.59486166 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Drug metabolism - cytochrome P450 0 -0.570158103 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Drug metabolism - other enzymes 0 -0.41798419 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Endocytosis 0 0 0.550836551 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Fanconi anemia pathway 0 -0.429841897 -0.459202059 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Fatty acid elongation 0 -0.546442688 -0.533075933 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Focal adhesion 0 -0.436758893 0 kegg kegg NA NA no no no no up up Cytosolic DNA-sensing pathway FoxO signaling pathway 0 0 -0.629086229 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Glycolysis / Gluconeogenesis 0 0 -0.485714286 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.437747036 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Histidine metabolism 0 -0.433794466 -0.599485199 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Homologous recombination 0 0 -0.534105534 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Inositol phosphate metabolism 0 0 -0.468725869 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Lachnospira 0 -0.416604905 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Cytosolic DNA-sensing pathway Longevity regulating pathway - multiple species -0.494782609 0 -0.414414414 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Metabolism of xenobiotics by cytochrome P450 0 -0.599802372 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Mismatch repair 0 -0.711462451 -0.421879022 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway NF-kappa B signaling pathway 0 0.597826087 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway NOD-like receptor signaling pathway 0 0.520750988 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Non-homologous end-joining 0 -0.652173913 -0.443243243 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Nucleotide excision repair -0.475652174 -0.640316206 -0.516602317 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway One carbon pool by folate -0.50173913 -0.710474308 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Oocyte meiosis 0 -0.428853755 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway p53 signaling pathway 0 0 -0.446846847 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Pentose and glucuronate interconversions 0 -0.420948617 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Phenylalanine metabolism 0 -0.654150198 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Phosphatidylinositol signaling system 0 -0.424901186 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Platinum drug resistance -0.452173913 0 -0.645045045 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway PPAR signaling pathway 0 0.52173913 0.445302445 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Primary bile acid biosynthesis -0.445217391 -0.571146245 -0.52998713 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Propanoate metabolism 0 -0.546442688 -0.427284427 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Pyrimidine metabolism 0 -0.627470356 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Pyruvate metabolism -0.409565217 -0.514822134 -0.505534106 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Retinol metabolism 0 -0.735177866 -0.519433719 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Ribosome biogenesis in eukaryotes 0 -0.432806324 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway RIG-I-like receptor signaling pathway 0 0.658102767 0.447104247 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Selenocompound metabolism 0 0 -0.553667954 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Sphingolipid signaling pathway 0 0.495059289 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Steroid biosynthesis -0.453043478 -0.753952569 -0.472586873 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Steroid hormone biosynthesis 0 -0.814229249 0 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Synthesis and degradation of ketone bodies 0 -0.652173913 -0.423938224 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Toll-like receptor signaling pathway 0.453913043 0.606719368 0.735907336 yes kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Tryptophan metabolism 0 -0.700592885 -0.494208494 kegg kegg NA NA no no no no up no Cytosolic DNA-sensing pathway Tyrosine metabolism -0.427826087 -0.806324111 -0.567567568 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.704545455 -0.40978121 kegg kegg NA NA no no no no no no Cytosolic DNA-sensing pathway "Valine, leucine and isoleucine degradation" 0 -0.649209486 -0.513770914 kegg kegg NA NA no no no no no no d18:0-16:0-SM+blood 12-HEPE+blood 0 0 -0.436717961 serum_phospholipids serum_ARA 0.202 0.312 no no no no no no d18:0-16:0-SM+blood "12,13-EPOME+blood" 0 -0.711504645 0 serum_phospholipids serum_ARA 0.202 0.901 no no no no no no d18:0-16:0-SM+blood 16:0-LPC+blood 0 0.539215686 0 serum_phospholipids serum_phospholipids 0.202 0.00456 no no no up up no d18:0-16:0-SM+blood 16:0/18:2-PC+blood 0 0 -0.644444444 serum_phospholipids serum_phospholipids 0.202 3.24E-06 no no no no up up d18:0-16:0-SM+blood 16:0/20:3-PC+blood 0 -0.482843137 0 serum_phospholipids serum_phospholipids 0.202 5.43E-06 no no no no up up d18:0-16:0-SM+blood 16:0/20:5-PG+blood 0.55037594 0 0.568547009 serum_phospholipids serum_phospholipids 0.202 0.00656 no no no no up no d18:0-16:0-SM+blood 16:0/22:6-PC+blood 0 0 -0.578803419 serum_phospholipids serum_phospholipids 0.202 4.53E-05 no no no no up up d18:0-16:0-SM+blood 16:1/16:0-PC+blood 0 0 -0.648547009 serum_phospholipids serum_phospholipids 0.202 0.0215 no no no no up up d18:0-16:0-SM+blood 16:1/16:1-PC+blood 0 0 -0.472136752 serum_phospholipids serum_phospholipids 0.202 0.0177 no no no no no up d18:0-16:0-SM+blood 16:1/18:1-PG+blood 0 0 0.556239316 serum_phospholipids serum_phospholipids 0.202 3.21E-05 no no no no up up d18:0-16:0-SM+blood 16:1/18:2-PG+blood 0 0 0.448205128 serum_phospholipids serum_phospholipids 0.202 1.40E-08 no no no no up up d18:0-16:0-SM+blood 18:0/18:1-PI+blood 0 0 0.547350427 serum_phospholipids serum_phospholipids 0.202 0.599 no no no no no no d18:0-16:0-SM+blood 18:0/18:2-PC+blood 0 -0.588235294 -0.486495726 serum_phospholipids serum_phospholipids 0.202 1.74E-06 no no no no up up d18:0-16:0-SM+blood 18:0/18:2-PI+blood 0 0 0.496068376 serum_phospholipids serum_phospholipids 0.202 0.179 no no no no no no d18:0-16:0-SM+blood 18:0/22:6-PC+blood -0.446616541 0 -0.55008547 serum_phospholipids serum_phospholipids 0.202 0.0775 no no no no no up d18:0-16:0-SM+blood 18:1/16:0-PC+blood 0 0 -0.647863248 serum_phospholipids serum_phospholipids 0.202 2.43E-05 no no no no up up d18:0-16:0-SM+blood 18:1/18:0-PC+blood 0 -0.566176471 -0.512478632 serum_phospholipids serum_phospholipids 0.202 1.83E-06 no no no no up up d18:0-16:0-SM+blood 18:1/18:0-PI+blood 0 0 0.422222222 serum_phospholipids serum_phospholipids 0.202 0.0931 no no no no no up d18:0-16:0-SM+blood 18:1/18:1-PG+blood 0 0 0.593162393 serum_phospholipids serum_phospholipids 0.202 0.00352 no no no no up up d18:0-16:0-SM+blood 18:1/18:1-PI+blood 0 0 0.417435897 serum_phospholipids serum_phospholipids 0.202 0.111 no no no dn no no d18:0-16:0-SM+blood 18:1/18:2-PG+blood 0 0 0.473504274 serum_phospholipids serum_phospholipids 0.202 5.58E-07 no no no no up up d18:0-16:0-SM+blood 18:1/20:4-PE+blood 0.569924812 0 0 serum_phospholipids serum_phospholipids 0.202 0.0578 no no no up no no d18:0-16:0-SM+blood 18:1/22:6-PE+blood 0.487218045 0 0 serum_phospholipids serum_phospholipids 0.202 0.0047 no no no no up no d18:0-16:0-SM+blood 18:2/16:0-PC+blood 0 0 -0.437264957 serum_phospholipids serum_phospholipids 0.202 8.67E-05 no no no no up up d18:0-16:0-SM+blood 18:2/18:2-PS+blood 0 0 0.530940171 serum_phospholipids serum_phospholipids 0.202 0.00674 no no no up up no d18:0-16:0-SM+blood 18:3n3+blood 0 0 -0.40034188 serum_phospholipids serum_fattyacid 0.202 0.291 no no no no no no d18:0-16:0-SM+blood 18:3n6+blood 0 0 0.432478632 serum_phospholipids serum_fattyacid 0.202 0.0463 no no no up no dn d18:0-16:0-SM+blood 20:0/20:4-PE+blood 0.551879699 0 0.413333333 serum_phospholipids serum_phospholipids 0.202 0.00128 no no no up up no d18:0-16:0-SM+blood 20:1-LPA+blood 0 0 0.404444444 serum_phospholipids serum_phospholipids 0.202 0.0187 no no no dn dn no d18:0-16:0-SM+blood 20:1/20:4-PC+blood -0.473684211 0 -0.513162393 serum_phospholipids serum_phospholipids 0.202 0.0419 no no no no no up d18:0-16:0-SM+blood 20:1/20:4-PE+blood 0.769924812 0 0 serum_phospholipids serum_phospholipids 0.202 0.0042 no no no up up no d18:0-16:0-SM+blood 20:2/18:3-PE+blood 0.667669173 0 0 serum_phospholipids serum_phospholipids 0.202 0.0391 no no no up up no d18:0-16:0-SM+blood 20:4-LPC+blood 0 0 0.44957265 serum_phospholipids serum_phospholipids 0.202 0.949 no no no no no no d18:0-16:0-SM+blood 20:4-LPE+blood 0.508270677 0 0 serum_phospholipids serum_phospholipids 0.202 0.552 no no no no no no d18:0-16:0-SM+blood 20:4/18:0-PE+blood 0.484210526 0 0 serum_phospholipids serum_phospholipids 0.202 0.000755 no no no up up no d18:0-16:0-SM+blood 20:4n6+blood 0.529323308 0 0 serum_phospholipids serum_fattyacid 0.202 0.133 no no no no no no d18:0-16:0-SM+blood 20:5/18:0-PC+blood 0 0 -0.629401709 serum_phospholipids serum_phospholipids 0.202 3.97E-06 no no no no up up d18:0-16:0-SM+blood 24:0+blood 0.448120301 0 0 serum_phospholipids serum_fattyacid 0.202 0.034 no no no dn no up d18:0-16:0-SM+blood 8-HETE+blood 0.541353383 0 0 serum_phospholipids serum_ARA 0.202 0.741 no no no no no no d18:0-16:0-SM+blood Adrenergic signaling in cardiomyocytes 0 0 0.442307692 serum_phospholipids kegg 0.202 NA no no no no no up d18:0-16:0-SM+blood Aldosterone synthesis and secretion 0 0 0.46 serum_phospholipids kegg 0.202 NA no no no no up up d18:0-16:0-SM+blood Amphetamine addiction 0 0 0.463076923 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Antigen processing and presentation 0 -0.617647059 0 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Calcium signaling pathway 0 0 0.473846154 serum_phospholipids kegg 0.202 NA no no no no up up d18:0-16:0-SM+blood Choline metabolism in cancer 0 0.508823529 0 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Clostridium -0.449793187 0 0 serum_phospholipids Genus 0.202 0.925 no no no no no no d18:0-16:0-SM+blood Cocaine addiction 0 0 0.437692308 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Dopaminergic synapse 0 0 0.457692308 serum_phospholipids kegg 0.202 NA no no no no up no d18:0-16:0-SM+blood Epstein-Barr virus infection 0 -0.576470588 0 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood GDCA+stool 0.659340659 0 0 serum_phospholipids stool_bileacids 0.202 0.656 no no no no no no d18:0-16:0-SM+blood Gemmiger 0 0.496315994 0 butyrate-producing serum_phospholipids Genus 0.202 0.595 no no no no no no d18:0-16:0-SM+blood GnRH signaling pathway 0 0 0.463846154 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Hematopoietic cell lineage -0.485964912 0 0 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Herpes simplex virus 1 infection 0 -0.617647059 0 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Human cytomegalovirus infection 0 -0.532352941 0 serum_phospholipids kegg 0.202 NA no no no no no dn d18:0-16:0-SM+blood Human immunodeficiency virus 1 infection 0 -0.544117647 0 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Human T-cell leukemia virus 1 infection 0 -0.597058824 0 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Inflammatory mediator regulation of TRP channels 0 0 0.443846154 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Long-term depression 0 0 0.416923077 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Longevity regulating pathway - multiple species 0 0 -0.41 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Malaria -0.51754386 0 0 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Melanogenesis 0 0 0.433076923 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Mineral absorption -0.503508772 0 0 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Pancreatic secretion 0 0 0.466153846 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Peroxisome 0 0 -0.523076923 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Retrograde endocannabinoid signaling 0.468421053 0 0 serum_phospholipids kegg 0.202 NA no no no no no up d18:0-16:0-SM+blood Ruminococcus 0 0 0.413286326 serum_phospholipids Genus 0.202 0.0679 no no no no no dn d18:0-16:0-SM+blood Signaling pathways regulating pluripotency of stem cells 0 0.514705882 0 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-16:0-SM+blood Vasopressin-regulated water reabsorption 0 0 0.420769231 serum_phospholipids kegg 0.202 NA no no no no no no d18:0-18:3-SM+blood 11-HETE+blood 0 -0.616595352 0 serum_phospholipids serum_ARA 0.0879 0.464 no dn no no no no d18:0-18:3-SM+blood 14:0-LPC+blood -0.460150376 0 0 serum_phospholipids serum_phospholipids 0.0879 0.00689 no dn no up up no d18:0-18:3-SM+blood 14:0/20:4-PC+blood 0 0 0.585641026 serum_phospholipids serum_phospholipids 0.0879 0.486 no dn no no no no d18:0-18:3-SM+blood 16:0-LPC+blood 0 0.644607843 0 serum_phospholipids serum_phospholipids 0.0879 0.00456 no dn no up up no d18:0-18:3-SM+blood 16:0/16:1-PC+blood 0 -0.485294118 0 serum_phospholipids serum_phospholipids 0.0879 0.00283 no dn no up up no d18:0-18:3-SM+blood 16:0/18:0-PS+blood 0.461654135 0 0 serum_phospholipids serum_phospholipids 0.0879 0.377 no dn no no no no d18:0-18:3-SM+blood 16:0/18:1-PC+blood 0 0 -0.485128205 serum_phospholipids serum_phospholipids 0.0879 6.15E-07 no dn no up up up d18:0-18:3-SM+blood 16:0/18:1-PE+blood 0 -0.578431373 -0.403760684 serum_phospholipids serum_phospholipids 0.0879 0.000107 no dn no up up no d18:0-18:3-SM+blood 16:0/18:2-PC+blood 0 -0.49754902 -0.64034188 serum_phospholipids serum_phospholipids 0.0879 3.24E-06 no dn no no up up d18:0-18:3-SM+blood 16:0/18:3-PC+blood 0.461654135 0.556372549 0 serum_phospholipids serum_phospholipids 0.0879 0.00216 no dn no no up up d18:0-18:3-SM+blood 16:0/20:3-PC+blood 0 -0.526960784 0 serum_phospholipids serum_phospholipids 0.0879 5.43E-06 no dn no no up up d18:0-18:3-SM+blood 16:0/22:6-PE+blood 0.536842105 0 0 serum_phospholipids serum_phospholipids 0.0879 0.000934 no dn no up up no d18:0-18:3-SM+blood 18:0/16:0-PC+blood 0 0 -0.496068376 serum_phospholipids serum_phospholipids 0.0879 9.64E-07 no dn no up up up d18:0-18:3-SM+blood 18:0/20:3-PI+blood 0 -0.544117647 0 serum_phospholipids serum_phospholipids 0.0879 0.377 no dn no no no no d18:0-18:3-SM+blood 18:0/22:6-PC+blood 0 0 -0.425641026 serum_phospholipids serum_phospholipids 0.0879 0.0775 no dn no no no up d18:0-18:3-SM+blood 18:1/16:0-PC+blood 0 0 -0.632820513 serum_phospholipids serum_phospholipids 0.0879 2.43E-05 no dn no no up up d18:0-18:3-SM+blood 18:1/16:1-PE+blood 0 -0.553921569 -0.416068376 serum_phospholipids serum_phospholipids 0.0879 0.000184 no dn no up up no d18:0-18:3-SM+blood 18:1/18:1-PC+blood 0 -0.573529412 0 serum_phospholipids serum_phospholipids 0.0879 1.34E-05 no dn no no up up d18:0-18:3-SM+blood 18:1/20:4-PE+blood 0.648120301 0 0 serum_phospholipids serum_phospholipids 0.0879 0.0578 no dn no up no no d18:0-18:3-SM+blood 18:1/22:6-PE+blood 0.535338346 0 0 serum_phospholipids serum_phospholipids 0.0879 0.0047 no dn no no up no d18:0-18:3-SM+blood 18:3/18:2-PC+blood 0.506766917 0.786764706 0 serum_phospholipids serum_phospholipids 0.0879 0.0394 no dn no no no up d18:0-18:3-SM+blood 18:3n3+blood 0.448120301 0 0 serum_phospholipids serum_fattyacid 0.0879 0.291 no dn no no no no d18:0-18:3-SM+blood 20:0/20:5-PC+blood 0.490225564 0 0 serum_phospholipids serum_phospholipids 0.0879 0.882 no dn no no no no d18:0-18:3-SM+blood 20:1/20:4-PE+blood 0.70075188 0 0 serum_phospholipids serum_phospholipids 0.0879 0.0042 no dn no up up no d18:0-18:3-SM+blood 20:2/18:3-PE+blood 0.553383459 0 0 serum_phospholipids serum_phospholipids 0.0879 0.0391 no dn no up up no d18:0-18:3-SM+blood 20:3-LPE+blood 0 -0.56127451 0 serum_phospholipids serum_phospholipids 0.0879 0.084 no dn no no up no d18:0-18:3-SM+blood 20:3n6+blood 0 -0.49754902 0 serum_phospholipids serum_fattyacid 0.0879 0.0884 no dn no up no no d18:0-18:3-SM+blood 20:4/18:0-PE+blood 0.508270677 0 0 serum_phospholipids serum_phospholipids 0.0879 0.000755 no dn no up up no d18:0-18:3-SM+blood 20:4n6+blood 0.520300752 0 0 serum_phospholipids serum_fattyacid 0.0879 0.133 no dn no no no no d18:0-18:3-SM+blood 20:5/18:0-PC+blood 0 0 -0.439316239 serum_phospholipids serum_phospholipids 0.0879 3.97E-06 no dn no no up up d18:0-18:3-SM+blood d18:0-16:0-SM+blood 0.732330827 0 0.552136752 serum_phospholipids serum_phospholipids 0.0879 0.202 no dn no no no no d18:0-24:1-SM+blood 12-ketoDCA+blood 0 0.540081806 0 serum_phospholipids serum_bileacids 0.0609 0.517 no dn dn no no no d18:0-24:1-SM+blood "12,13-EPOME+blood" 0.465086256 0 0 serum_phospholipids serum_ARA 0.0609 0.901 no dn dn no no no d18:0-24:1-SM+blood 14:0/18:2-PC+blood 0 0 0.418803419 serum_phospholipids serum_phospholipids 0.0609 0.102 no dn dn no up no d18:0-24:1-SM+blood 14:0/20:4-PC+blood 0 0 0.402393162 serum_phospholipids serum_phospholipids 0.0609 0.486 no dn dn no no no d18:0-24:1-SM+blood 14:0+blood 0 -0.553921569 0 yes serum_phospholipids serum_fattyacid 0.0609 0.00572 no dn dn up no dn d18:0-24:1-SM+blood 14:1/18:2-PG+blood 0 0 0.444102564 serum_phospholipids serum_phospholipids 0.0609 0.00259 no dn dn no up up d18:0-24:1-SM+blood 16:0/18:2-PC+blood 0 0 -0.530940171 serum_phospholipids serum_phospholipids 0.0609 3.24E-06 no dn dn no up up d18:0-24:1-SM+blood 16:0/20:4-PC+blood 0 0 -0.554871795 serum_phospholipids serum_phospholipids 0.0609 0.0262 no dn dn no up no d18:0-24:1-SM+blood 16:1-LPC+blood 0 0 0.444102564 serum_phospholipids serum_phospholipids 0.0609 0.0241 no dn dn no up no d18:0-24:1-SM+blood 16:1/16:0-PC+blood 0 0 -0.574700855 serum_phospholipids serum_phospholipids 0.0609 0.0215 no dn dn no up up d18:0-24:1-SM+blood 16:1/16:1-PC+blood 0 0 -0.461880342 serum_phospholipids serum_phospholipids 0.0609 0.0177 no dn dn no no up d18:0-24:1-SM+blood 18:0/18:1-PI+blood 0 0 0.504273504 serum_phospholipids serum_phospholipids 0.0609 0.599 no dn dn no no no d18:0-24:1-SM+blood 18:0/18:2-PC+blood -0.454135338 0 -0.424957265 serum_phospholipids serum_phospholipids 0.0609 1.74E-06 no dn dn no up up d18:0-24:1-SM+blood 18:0/18:2-PI+blood 0 0 0.403076923 serum_phospholipids serum_phospholipids 0.0609 0.179 no dn dn no no no d18:0-24:1-SM+blood 18:0/20:2-PC+blood 0 0.764705882 0 serum_phospholipids serum_phospholipids 0.0609 0.733 no dn dn no no no d18:0-24:1-SM+blood 18:0/20:3-PC+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.0609 0.0682 no dn dn no up no d18:0-24:1-SM+blood 18:0/20:4-PC+blood 0 0 -0.427008547 serum_phospholipids serum_phospholipids 0.0609 0.454 no dn dn no no no d18:0-24:1-SM+blood 18:0/22:6-PC+blood -0.536842105 0 0 serum_phospholipids serum_phospholipids 0.0609 0.0775 no dn dn no no up d18:0-24:1-SM+blood 18:1/16:0-PC+blood 0 0 -0.530940171 serum_phospholipids serum_phospholipids 0.0609 2.43E-05 no dn dn no up up d18:0-24:1-SM+blood 18:1/16:0-PI+blood 0 0 0.461196581 serum_phospholipids serum_phospholipids 0.0609 0.793 no dn dn no no no d18:0-24:1-SM+blood 18:1/18:0-PC+blood -0.461654135 0 -0.47008547 serum_phospholipids serum_phospholipids 0.0609 1.83E-06 no dn dn no up up d18:0-24:1-SM+blood 18:1/18:0-PI+blood 0 0 0.460512821 serum_phospholipids serum_phospholipids 0.0609 0.0931 no dn dn no no up d18:0-24:1-SM+blood 18:1/22:6-PE+blood 0 0 -0.415384615 serum_phospholipids serum_phospholipids 0.0609 0.0047 no dn dn no up no d18:0-24:1-SM+blood 18:1+blood 0 -0.583333333 0 yes serum_phospholipids serum_fattyacid 0.0609 0.00202 no dn dn up no dn d18:0-24:1-SM+blood 18:2/16:0-PC+blood 0 0 -0.568547009 serum_phospholipids serum_phospholipids 0.0609 8.67E-05 no dn dn no up up d18:0-24:1-SM+blood 18:3n3+blood 0 -0.495098039 0 serum_phospholipids serum_fattyacid 0.0609 0.291 no dn dn no no no d18:0-24:1-SM+blood 20:0-LPC+blood 0 0.509803922 0 serum_phospholipids serum_phospholipids 0.0609 0.199 no dn dn no no no d18:0-24:1-SM+blood 20:1-LPA+blood -0.509774436 0 0 serum_phospholipids serum_phospholipids 0.0609 0.0187 no dn dn dn dn no d18:0-24:1-SM+blood 20:1-LPE+blood 0 0.50245098 0 serum_phospholipids serum_phospholipids 0.0609 0.465 no dn dn no no no d18:0-24:1-SM+blood 20:1/20:4-PC+blood -0.583458647 0 0 serum_phospholipids serum_phospholipids 0.0609 0.0419 no dn dn no no up d18:0-24:1-SM+blood 20:1/20:4-PE+blood 0.512781955 0 0 serum_phospholipids serum_phospholipids 0.0609 0.0042 no dn dn up up no d18:0-24:1-SM+blood 20:1+blood 0 0 0.461880342 yes serum_phospholipids serum_fattyacid 0.0609 2.56E-05 no dn dn dn dn dn d18:0-24:1-SM+blood 20:2/18:3-PE+blood 0.553383459 0 0 serum_phospholipids serum_phospholipids 0.0609 0.0391 no dn dn up up no d18:0-24:1-SM+blood 20:3-LPE+blood 0.44962406 0 0 serum_phospholipids serum_phospholipids 0.0609 0.084 no dn dn no up no d18:0-24:1-SM+blood 20:3/16:0-PC+blood 0 0 -0.534358974 serum_phospholipids serum_phospholipids 0.0609 0.00405 no dn dn no up up d18:0-24:1-SM+blood 20:4-LPC+blood 0.463157895 0 0 serum_phospholipids serum_phospholipids 0.0609 0.949 no dn dn no no no d18:0-24:1-SM+blood 20:4-LPE+blood 0.511278195 0 0 serum_phospholipids serum_phospholipids 0.0609 0.552 no dn dn no no no d18:0-24:1-SM+blood 20:4n6+blood 0.593984962 0 0 serum_phospholipids serum_fattyacid 0.0609 0.133 no dn dn no no no d18:0-24:1-SM+blood 20:5/18:0-PC+blood -0.547368421 0 0 serum_phospholipids serum_phospholipids 0.0609 3.97E-06 no dn dn no up up d18:0-24:1-SM+blood 22:2-LPA+blood -0.484210526 0 0 serum_phospholipids serum_phospholipids 0.0609 0.0443 no dn dn dn no no d18:0-24:1-SM+blood 24:1+blood 0 -0.575980392 0 serum_phospholipids serum_fattyacid 0.0609 0.00582 no dn dn no dn dn d18:0-24:1-SM+blood Asthma 0 0 0.462307692 serum_phospholipids kegg 0.0609 NA no dn dn no no no d18:0-24:1-SM+blood Blautia 0 0 0.405148182 acetate-producing serum_phospholipids Genus 0.0609 1.36E-05 no dn dn up dn dn d18:0-24:1-SM+blood Butyricimonas 0 0 -0.422082098 butyrate-producing serum_phospholipids Genus 0.0609 0.17 no dn dn no no no d18:0-24:1-SM+blood Clostridium -0.679202756 0 0 serum_phospholipids Genus 0.0609 0.925 no dn dn no no no d18:0-24:1-SM+blood d18:0-16:0-SM+blood 0.747368421 0 0.552136752 serum_phospholipids serum_phospholipids 0.0609 0.202 no dn dn no no no d18:0-24:1-SM+blood GABAergic synapse 0 0 -0.423846154 serum_phospholipids kegg 0.0609 NA no dn dn no up up d18:0-24:1-SM+blood Inflammatory bowel disease 0 0 0.539230769 serum_phospholipids kegg 0.0609 NA no dn dn no no no d18:0-24:1-SM+blood Intestinal immune network for IgA production 0 0 0.414615385 serum_phospholipids kegg 0.0609 NA no dn dn no no no d18:0-24:1-SM+blood Lachnospira 0 0 -0.403767715 butyrate-producing serum_phospholipids Genus 0.0609 0.279 no dn dn no no no d18:0-24:1-SM+blood Legionellosis 0 0.517647059 0 serum_phospholipids kegg 0.0609 NA no dn dn no no no d18:0-24:1-SM+blood Mineral absorption 0 0 -0.41 serum_phospholipids kegg 0.0609 NA no dn dn no no no d18:0-24:1-SM+blood Necroptosis 0 0 -0.457692308 serum_phospholipids kegg 0.0609 NA no dn dn no no no d18:0-24:1-SM+blood Odoribacter 0 0 -0.42327702 butyrate-producing serum_phospholipids Genus 0.0609 0.798 no dn dn no no no d18:0-24:1-SM+blood Th1 and Th2 cell differentiation 0 0 0.521538462 serum_phospholipids kegg 0.0609 NA no dn dn no no no d18:0-24:1-SM+blood Th17 cell differentiation 0 0 0.543846154 serum_phospholipids kegg 0.0609 NA no dn dn no no no d18:0-24:1-SM+blood Thyroid hormone signaling pathway 0 0 0.405384615 serum_phospholipids kegg 0.0609 NA no dn dn no no no d18:1-14:0-SM+blood 13-HODE+blood 0 -0.642156863 0 serum_phospholipids serum_ARA 0.94 0.32 no no no no no no d18:1-14:0-SM+blood 14:0-LPC+blood 0 0 0.476923077 serum_phospholipids serum_phospholipids 0.94 0.00689 no no no up up no d18:1-14:0-SM+blood 14:0/18:2-PC+blood 0 0 0.676581197 serum_phospholipids serum_phospholipids 0.94 0.102 no no no no up no d18:1-14:0-SM+blood 14:0/20:4-PC+blood 0.618045113 0.531862745 0.703247863 serum_phospholipids serum_phospholipids 0.94 0.486 no no no no no no d18:1-14:0-SM+blood 14:1/18:2-PG+blood 0 0 0.576752137 serum_phospholipids serum_phospholipids 0.94 0.00259 no no no no up up d18:1-14:0-SM+blood 16:0-LPC+blood 0 0 0.414700855 serum_phospholipids serum_phospholipids 0.94 0.00456 no no no up up no d18:1-14:0-SM+blood 16:0/14:0-PC+blood 0 0 -0.604786325 serum_phospholipids serum_phospholipids 0.94 0.0206 no no no no up up d18:1-14:0-SM+blood 16:0/16:0-PI+blood 0.445112782 0 0 serum_phospholipids serum_phospholipids 0.94 0.358 no no no no no no d18:1-14:0-SM+blood 16:0/18:0-PS+blood 0.511278195 0 0.401709402 serum_phospholipids serum_phospholipids 0.94 0.377 no no no no no no d18:1-14:0-SM+blood 16:0/18:1-PC+blood 0 0 -0.487179487 serum_phospholipids serum_phospholipids 0.94 6.15E-07 no no no up up up d18:1-14:0-SM+blood 16:0/18:2-PC+blood 0 -0.539215686 -0.844786325 serum_phospholipids serum_phospholipids 0.94 3.24E-06 no no no no up up d18:1-14:0-SM+blood 16:0/20:4-PC+blood 0 0 -0.617777778 serum_phospholipids serum_phospholipids 0.94 0.0262 no no no no up no d18:1-14:0-SM+blood 16:0/20:4-PI+blood 0.508270677 0 0 serum_phospholipids serum_phospholipids 0.94 0.558 no no no no no no d18:1-14:0-SM+blood 16:0/20:5-PC+blood 0 0.56127451 0 serum_phospholipids serum_phospholipids 0.94 0.628 no no no no no no d18:1-14:0-SM+blood 16:0/22:6-PC+blood 0 0 -0.463247863 serum_phospholipids serum_phospholipids 0.94 4.53E-05 no no no no up up d18:1-14:0-SM+blood 16:0/22:6-PE+blood 0.461654135 0 0 serum_phospholipids serum_phospholipids 0.94 0.000934 no no no up up no d18:1-14:0-SM+blood 16:1/16:0-PC+blood 0 0 -0.67042735 serum_phospholipids serum_phospholipids 0.94 0.0215 no no no no up up d18:1-14:0-SM+blood 18:0/16:0-PC+blood 0 0 -0.506324786 serum_phospholipids serum_phospholipids 0.94 9.64E-07 no no no up up up d18:1-14:0-SM+blood 18:0/18:0-PE+blood 0 0 0.40991453 serum_phospholipids serum_phospholipids 0.94 0.00896 no no no up up no d18:1-14:0-SM+blood 18:0/18:0-PS+blood 0.559398496 0.487745098 0 serum_phospholipids serum_phospholipids 0.94 0.00617 no no no no up no d18:1-14:0-SM+blood 18:0/18:2-PC+blood -0.446616541 0 -0.622564103 serum_phospholipids serum_phospholipids 0.94 1.74E-06 no no no no up up d18:1-14:0-SM+blood 18:0/20:4-PC+blood 0 0 -0.476239316 serum_phospholipids serum_phospholipids 0.94 0.454 no no no no no no d18:1-14:0-SM+blood 18:0/20:5-PC+blood 0 0 -0.465299145 serum_phospholipids serum_phospholipids 0.94 0.17 no no no no no no d18:1-14:0-SM+blood 18:0/22:6-PE+blood 0.49924812 0 0 serum_phospholipids serum_phospholipids 0.94 0.00022 no no no up up no d18:1-14:0-SM+blood 18:1/16:0-PC+blood 0 -0.553921569 -0.857094017 serum_phospholipids serum_phospholipids 0.94 2.43E-05 no no no no up up d18:1-14:0-SM+blood 18:1/18:0-PC+blood 0 0 -0.647863248 serum_phospholipids serum_phospholipids 0.94 1.83E-06 no no no no up up d18:1-14:0-SM+blood 18:1/20:4-PC+blood 0 0 -0.426324786 serum_phospholipids serum_phospholipids 0.94 0.582 no no no no no no d18:1-14:0-SM+blood 18:2-LPC+blood -0.454135338 0 0 serum_phospholipids serum_phospholipids 0.94 0.00743 no no no dn no up d18:1-14:0-SM+blood 18:2/16:0-PC+blood 0 -0.490196078 -0.483076923 serum_phospholipids serum_phospholipids 0.94 8.67E-05 no no no no up up d18:1-14:0-SM+blood 18:3/16:0-PE+blood 0.454135338 0 0 serum_phospholipids serum_phospholipids 0.94 0.00149 no no no up up no d18:1-14:0-SM+blood 18:3/18:2-PC+blood 0.469172932 0 0 serum_phospholipids serum_phospholipids 0.94 0.0394 no no no no no up d18:1-14:0-SM+blood 20:0/20:5-PC+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 0.94 0.882 no no no no no no d18:1-14:0-SM+blood 20:1/20:4-PC+blood 0 0 -0.415384615 serum_phospholipids serum_phospholipids 0.94 0.0419 no no no no no up d18:1-14:0-SM+blood 20:2/18:1-PE+blood 0.458646617 0 0 serum_phospholipids serum_phospholipids 0.94 0.00208 no no no up up no d18:1-14:0-SM+blood 20:2+blood 0 -0.544117647 0 serum_phospholipids serum_fattyacid 0.94 0.478 no no no no no no d18:1-14:0-SM+blood 20:3/16:0-PC+blood 0 0 -0.661538462 serum_phospholipids serum_phospholipids 0.94 0.00405 no no no no up up d18:1-14:0-SM+blood 20:5/18:0-PC+blood 0 0 -0.491282051 serum_phospholipids serum_phospholipids 0.94 3.97E-06 no no no no up up d18:1-14:0-SM+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 0.47518797 serum_phospholipids stool_cometabolism 0.94 0.33 no no no no no no d18:1-14:0-SM+blood 8-HETE+blood 0 -0.512254902 0 serum_phospholipids serum_ARA 0.94 0.741 no no no no no no d18:1-14:0-SM+blood ACA+blood -0.571993654 0 0 serum_phospholipids serum_bileacids 0.94 0.338 no no no no no no d18:1-14:0-SM+blood Adipocytokine signaling pathway -0.470175439 0 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Alcoholism 0 -0.558823529 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Amoebiasis -0.503508772 -0.552941176 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood AMPK signaling pathway -0.459649123 0 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Amyotrophic lateral sclerosis 0 0 0.452307692 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Apelin signaling pathway 0 0.552941176 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Asthma -0.624561404 0 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood B cell receptor signaling pathway 0 -0.505882353 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Bifidobacterium 0.600225691 0 0 acetate-producing serum_phospholipids Genus 0.94 0.105 no no no no dn no d18:1-14:0-SM+blood Bladder cancer 0 -0.561764706 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Butyricimonas 0 0 -0.400436862 butyrate-producing serum_phospholipids Genus 0.94 0.17 no no no no no no d18:1-14:0-SM+blood C-type lectin receptor signaling pathway 0 -0.514705882 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood cAMP signaling pathway 0 -0.579411765 0 yes serum_phospholipids kegg 0.94 NA no no no no up up d18:1-14:0-SM+blood Cardiac muscle contraction 0 0 0.408461538 serum_phospholipids kegg 0.94 NA no no no no no up d18:1-14:0-SM+blood Cell cycle 0.475438596 0.585294118 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Central carbon metabolism in cancer 0 0.65 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Chagas disease 0 -0.517647059 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Chemokine signaling pathway 0 -0.517647059 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Clostridium 0.461075625 0 0 serum_phospholipids Genus 0.94 0.925 no no no no no no d18:1-14:0-SM+blood Colorectal cancer 0 0.555882353 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Cysteine+blood 0 0 -0.406495726 yes serum_phospholipids serum_aminoacids 0.94 1.81E-07 no no no dn up up d18:1-14:0-SM+blood Cystine+blood -0.506766917 -0.524509804 0 yes serum_phospholipids serum_aminoacids 0.94 0.00028 no no no up up no d18:1-14:0-SM+blood d18:0-16:0-SM+blood 0 0 0.551452991 serum_phospholipids serum_phospholipids 0.94 0.202 no no no no no no d18:1-14:0-SM+blood d18:0-18:3-SM+blood 0.505263158 0.482843137 0.641025641 serum_phospholipids serum_phospholipids 0.94 0.0879 no no no no dn no d18:1-14:0-SM+blood d18:0-24:1-SM+blood 0 0.495098039 0.653333333 serum_phospholipids serum_phospholipids 0.94 0.0609 no no no no dn dn d18:1-14:0-SM+blood EGFR tyrosine kinase inhibitor resistance 0 0.597058824 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Epithelial cell signaling in Helicobacter pylori infection 0 -0.55 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Faecalibacterium 0 -0.512254902 0 butyrate-producing serum_phospholipids Genus 0.94 0.0039 no no no no dn dn d18:1-14:0-SM+blood Ferroptosis -0.464912281 -0.529411765 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Gap junction 0 0 0.422307692 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Glutamatergic synapse -0.642105263 0 0 serum_phospholipids kegg 0.94 NA no no no no up up d18:1-14:0-SM+blood Glycolysis / Gluconeogenesis 0 0.535294118 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Hematopoietic cell lineage -0.466666667 0.505882353 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood HIF-1 signaling pathway 0 0.594117647 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Huntington disease 0 0 0.406923077 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood IL-17 signaling pathway 0 0 -0.453846154 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Inflammatory bowel disease -0.494736842 0 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Insulin signaling pathway 0 0.576470588 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Intestinal immune network for IgA production -0.649122807 0 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Lachnospira 0 0 -0.482192488 butyrate-producing serum_phospholipids Genus 0.94 0.279 no no no no no no d18:1-14:0-SM+blood Legionellosis 0.596491228 0.544117647 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Leishmaniasis 0.575438596 0.552941176 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Lipid and atherosclerosis 0 -0.502941176 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Long-term depression -0.543859649 0 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Longevity regulating pathway -0.510526316 0 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Measles 0.50877193 0 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Methanobrevibacter 0 0.525105032 0 serum_phospholipids Genus 0.94 0.629 no no no no no no d18:1-14:0-SM+blood Morphine addiction -0.480701754 0 0 serum_phospholipids kegg 0.94 NA no no no no up up d18:1-14:0-SM+blood mTOR signaling pathway 0 0.573529412 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Non-alcoholic fatty liver disease 0 0 0.581538462 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood nutriCA+stool 0 0.614704769 0 serum_phospholipids stool_bileacids 0.94 0.481 no no no no no no d18:1-14:0-SM+blood Oocyte meiosis 0 0.573529412 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Parabacteroides 0 0.536764706 0 serum_phospholipids Genus 0.94 4.19E-05 no no no no up up d18:1-14:0-SM+blood Phospholipase D signaling pathway 0 -0.526470588 0 serum_phospholipids kegg 0.94 NA no no no no up up d18:1-14:0-SM+blood PI3K-Akt signaling pathway 0.549122807 0 0 yes serum_phospholipids kegg 0.94 NA no no no no up up d18:1-14:0-SM+blood Proteasome 0 0 -0.404615385 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Protein processing in endoplasmic reticulum 0 0.529411765 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Proteoglycans in cancer 0 0.655882353 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Ras signaling pathway 0 0.514705882 0 yes serum_phospholipids kegg 0.94 NA no no no no up up d18:1-14:0-SM+blood Relaxin signaling pathway 0 -0.508823529 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Ribosome biogenesis in eukaryotes 0 0.508823529 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood RNA degradation 0 0.544117647 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood RNA transport 0.564912281 0.682352941 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Ruminococcus 0 0 0.505296713 serum_phospholipids Genus 0.94 0.0679 no no no no no dn d18:1-14:0-SM+blood Salivary secretion -0.531578947 0 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Spinocerebellar ataxia 0 0.647058824 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood T cell receptor signaling pathway 0.484210526 0 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Toll-like receptor signaling pathway 0 -0.552941176 0 yes serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Transcriptional misregulation in cancer 0 -0.529411765 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood TUDCA+stool 0 -0.705458603 0 serum_phospholipids stool_bileacids 0.94 0.241 no no no no no no d18:1-14:0-SM+blood Viral protein interaction with cytokine and cytokine receptor 0 -0.514705882 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:0-SM+blood Wnt signaling pathway 0 0.629411765 0 serum_phospholipids kegg 0.94 NA no no no no no no d18:1-14:1-SM+blood 13-HODE+blood 0 -0.546568627 0 serum_phospholipids serum_ARA 0.0952 0.32 no dn no no no no d18:1-14:1-SM+blood 14:0-LPC+blood 0 0 0.427692308 serum_phospholipids serum_phospholipids 0.0952 0.00689 no dn no up up no d18:1-14:1-SM+blood 14:0/16:0-PC+blood 0.497744361 0 0 serum_phospholipids serum_phospholipids 0.0952 0.0358 no dn no no up no d18:1-14:1-SM+blood 14:0/18:2-PC+blood 0 0 0.649230769 serum_phospholipids serum_phospholipids 0.0952 0.102 no dn no no up no d18:1-14:1-SM+blood 14:0/20:4-PC+blood 0.65112782 0 0.737435897 serum_phospholipids serum_phospholipids 0.0952 0.486 no dn no no no no d18:1-14:1-SM+blood 14:1/18:2-PG+blood 0 0 0.537777778 serum_phospholipids serum_phospholipids 0.0952 0.00259 no dn no no up up d18:1-14:1-SM+blood 16:0/14:0-PC+blood 0 0 -0.447521368 serum_phospholipids serum_phospholipids 0.0952 0.0206 no dn no no up up d18:1-14:1-SM+blood 16:0/18:0-PS+blood 0.589473684 0 0 serum_phospholipids serum_phospholipids 0.0952 0.377 no dn no no no no d18:1-14:1-SM+blood 16:0/18:2-PC+blood 0 -0.602941176 -0.718290598 serum_phospholipids serum_phospholipids 0.0952 3.24E-06 no dn no no up up d18:1-14:1-SM+blood 16:0/18:3-PC+blood 0 0 0.473504274 serum_phospholipids serum_phospholipids 0.0952 0.00216 no dn no no up up d18:1-14:1-SM+blood 16:0/20:4-PC+blood 0 0 -0.416752137 serum_phospholipids serum_phospholipids 0.0952 0.0262 no dn no no up no d18:1-14:1-SM+blood 16:0/20:4-PI+blood 0.469172932 0.585784314 0 serum_phospholipids serum_phospholipids 0.0952 0.558 no dn no no no no d18:1-14:1-SM+blood 16:0/22:6-PC+blood 0 0 -0.537094017 serum_phospholipids serum_phospholipids 0.0952 4.53E-05 no dn no no up up d18:1-14:1-SM+blood 16:1/16:0-PC+blood 0 0 -0.568547009 serum_phospholipids serum_phospholipids 0.0952 0.0215 no dn no no up up d18:1-14:1-SM+blood 18:0-LPC+blood 0 0.610294118 0 serum_phospholipids serum_phospholipids 0.0952 0.554 no dn no no no no d18:1-14:1-SM+blood 18:0/18:0-PS+blood 0.593984962 0 0 serum_phospholipids serum_phospholipids 0.0952 0.00617 no dn no no up no d18:1-14:1-SM+blood 18:0/18:1-PC+blood 0 0.50245098 0 serum_phospholipids serum_phospholipids 0.0952 0.393 no dn no no no no d18:1-14:1-SM+blood 18:0/18:2-PC+blood 0 0 -0.567179487 serum_phospholipids serum_phospholipids 0.0952 1.74E-06 no dn no no up up d18:1-14:1-SM+blood 18:0/20:2-PC+blood 0 0.568627451 0 serum_phospholipids serum_phospholipids 0.0952 0.733 no dn no no no no d18:1-14:1-SM+blood 18:0/20:3-PC+blood 0 0.566176471 0 serum_phospholipids serum_phospholipids 0.0952 0.0682 no dn no no up no d18:1-14:1-SM+blood 18:0/22:6-PC+blood 0 0 -0.407863248 serum_phospholipids serum_phospholipids 0.0952 0.0775 no dn no no no up d18:1-14:1-SM+blood 18:1/16:0-PC+blood 0 -0.593137255 -0.726495726 serum_phospholipids serum_phospholipids 0.0952 2.43E-05 no dn no no up up d18:1-14:1-SM+blood 18:1/18:0-PC+blood 0 0 -0.573333333 serum_phospholipids serum_phospholipids 0.0952 1.83E-06 no dn no no up up d18:1-14:1-SM+blood 18:1/22:6-PE+blood 0 0 -0.404444444 serum_phospholipids serum_phospholipids 0.0952 0.0047 no dn no no up no d18:1-14:1-SM+blood 18:2-LPA+blood 0 -0.541666667 0 serum_phospholipids serum_phospholipids 0.0952 0.00684 no dn no dn no up d18:1-14:1-SM+blood 18:2-LPC+blood -0.535338346 -0.546568627 0 serum_phospholipids serum_phospholipids 0.0952 0.00743 no dn no dn no up d18:1-14:1-SM+blood 18:2/16:0-PC+blood 0 -0.541666667 -0.476923077 serum_phospholipids serum_phospholipids 0.0952 8.67E-05 no dn no no up up d18:1-14:1-SM+blood 18:2n6c+blood 0 -0.495098039 0 serum_phospholipids serum_fattyacid 0.0952 0.15 no dn no no no no d18:1-14:1-SM+blood 18:3/16:0-PE+blood 0.470676692 0 0 serum_phospholipids serum_phospholipids 0.0952 0.00149 no dn no up up no d18:1-14:1-SM+blood 18:3/18:2-PC+blood 0.452631579 0 0 serum_phospholipids serum_phospholipids 0.0952 0.0394 no dn no no no up d18:1-14:1-SM+blood 18:3n3+blood 0 -0.485294118 0 serum_phospholipids serum_fattyacid 0.0952 0.291 no dn no no no no d18:1-14:1-SM+blood 18:3n6+blood 0.454135338 0 0.635555556 serum_phospholipids serum_fattyacid 0.0952 0.0463 no dn no up no dn d18:1-14:1-SM+blood 20:0-LPC+blood 0 0.482843137 0 serum_phospholipids serum_phospholipids 0.0952 0.199 no dn no no no no d18:1-14:1-SM+blood 20:0/20:4-PE+blood 0 0.522058824 0 serum_phospholipids serum_phospholipids 0.0952 0.00128 no dn no up up no d18:1-14:1-SM+blood 20:0/20:5-PC+blood 0 0.56127451 0 serum_phospholipids serum_phospholipids 0.0952 0.882 no dn no no no no d18:1-14:1-SM+blood 20:1/20:4-PC+blood 0 0 -0.401025641 serum_phospholipids serum_phospholipids 0.0952 0.0419 no dn no no no up d18:1-14:1-SM+blood 20:1/20:4-PE+blood 0 0.509803922 0 serum_phospholipids serum_phospholipids 0.0952 0.0042 no dn no up up no d18:1-14:1-SM+blood 20:2/18:0-PC+blood 0 0.575980392 0 serum_phospholipids serum_phospholipids 0.0952 0.0427 no dn no no up no d18:1-14:1-SM+blood 20:3/16:0-PC+blood 0 0 -0.478974359 serum_phospholipids serum_phospholipids 0.0952 0.00405 no dn no no up up d18:1-14:1-SM+blood 20:5/18:0-PC+blood 0 0 -0.525470085 serum_phospholipids serum_phospholipids 0.0952 3.97E-06 no dn no no up up d18:1-14:1-SM+blood 24:1+blood 0 -0.485294118 0 serum_phospholipids serum_fattyacid 0.0952 0.00582 no dn no no dn dn d18:1-14:1-SM+blood 8-HETE+blood 0 -0.551470588 0 serum_phospholipids serum_ARA 0.0952 0.741 no dn no no no no d18:1-14:1-SM+blood 9-HODE+blood 0 -0.546568627 0 serum_phospholipids serum_ARA 0.0952 0.297 no dn no no no no d18:1-14:1-SM+blood AA+blood 0 -0.5 0 serum_phospholipids serum_ARA 0.0952 0.212 no dn no no no no d18:1-14:1-SM+blood acetic acid C2+blood 0 0 -0.448205128 serum_phospholipids serum_scfa 0.0952 0.000193 no dn no up dn no d18:1-14:1-SM+blood Betaine+blood 0 -0.544117647 0 serum_phospholipids serum_choline 0.0952 0.857 no dn no no no no d18:1-14:1-SM+blood CDCA+blood 0 0 0.447521368 serum_phospholipids serum_bileacids 0.0952 0.506 no dn no no no no d18:1-14:1-SM+blood Choline+blood 0 -0.490196078 0 serum_phospholipids serum_choline 0.0952 0.0395 no dn no no up no d18:1-14:1-SM+blood Creatinine+blood -0.544360902 -0.558823529 0 serum_phospholipids serum_choline 0.0952 0.437 no dn no no no no d18:1-14:1-SM+blood Cystine+blood -0.584962406 0 0 yes serum_phospholipids serum_aminoacids 0.0952 0.00028 no dn no up up no d18:1-14:1-SM+blood d18:0-16:0-SM+blood 0 0 0.512478632 serum_phospholipids serum_phospholipids 0.0952 0.202 no dn no no no no d18:1-14:1-SM+blood d18:0-18:3-SM+blood 0.580451128 0 0.753162393 serum_phospholipids serum_phospholipids 0.0952 0.0879 no dn no no dn no d18:1-14:1-SM+blood d18:0-24:1-SM+blood 0 0.583333333 0.463931624 serum_phospholipids serum_phospholipids 0.0952 0.0609 no dn no no dn dn d18:1-14:1-SM+blood d18:1-14:0-SM+blood 0.828571429 0.708333333 0.835213675 serum_phospholipids serum_phospholipids 0.0952 0.94 no dn no no no no d18:1-16:0-SM+blood 12-HEPE+blood 0 0 -0.434730621 serum_phospholipids serum_ARA 0.14 0.312 no no no no no no d18:1-16:0-SM+blood "12,13-EPOME+blood" 0 -0.707746697 0 serum_phospholipids serum_ARA 0.14 0.901 no no no no no no d18:1-16:0-SM+blood 16:0-LPC+blood 0 0.546568627 0 serum_phospholipids serum_phospholipids 0.14 0.00456 no no no up up no d18:1-16:0-SM+blood 16:0/18:2-PC+blood 0 0 -0.597948718 serum_phospholipids serum_phospholipids 0.14 3.24E-06 no no no no up up d18:1-16:0-SM+blood 16:0/20:3-PC+blood 0 -0.49754902 0 serum_phospholipids serum_phospholipids 0.14 5.43E-06 no no no no up up d18:1-16:0-SM+blood 16:0/20:5-PG+blood 0.571428571 0 0.592478632 serum_phospholipids serum_phospholipids 0.14 0.00656 no no no no up no d18:1-16:0-SM+blood 16:0/22:6-PC+blood 0 0 -0.574017094 serum_phospholipids serum_phospholipids 0.14 4.53E-05 no no no no up up d18:1-16:0-SM+blood 16:1/16:0-PC+blood 0 0 -0.610940171 serum_phospholipids serum_phospholipids 0.14 0.0215 no no no no up up d18:1-16:0-SM+blood 16:1/16:1-PC+blood 0 0 -0.451623932 serum_phospholipids serum_phospholipids 0.14 0.0177 no no no no no up d18:1-16:0-SM+blood 16:1/18:1-PG+blood 0 0 0.521367521 serum_phospholipids serum_phospholipids 0.14 3.21E-05 no no no no up up d18:1-16:0-SM+blood 16:1/18:2-PG+blood 0 0 0.465982906 serum_phospholipids serum_phospholipids 0.14 1.40E-08 no no no no up up d18:1-16:0-SM+blood 18:0/18:1-PI+blood 0 0 0.543247863 serum_phospholipids serum_phospholipids 0.14 0.599 no no no no no no d18:1-16:0-SM+blood 18:0/18:2-PC+blood 0 -0.546568627 -0.442735043 serum_phospholipids serum_phospholipids 0.14 1.74E-06 no no no no up up d18:1-16:0-SM+blood 18:0/18:2-PI+blood 0 0 0.513162393 serum_phospholipids serum_phospholipids 0.14 0.179 no no no no no no d18:1-16:0-SM+blood 18:0/22:6-PC+blood -0.485714286 0 -0.536410256 serum_phospholipids serum_phospholipids 0.14 0.0775 no no no no no up d18:1-16:0-SM+blood 18:1/16:0-PC+blood 0 0 -0.600683761 serum_phospholipids serum_phospholipids 0.14 2.43E-05 no no no no up up d18:1-16:0-SM+blood 18:1/18:0-PC+blood 0 -0.524509804 -0.472136752 serum_phospholipids serum_phospholipids 0.14 1.83E-06 no no no no up up d18:1-16:0-SM+blood 18:1/18:0-PI+blood 0 0 0.448205128 serum_phospholipids serum_phospholipids 0.14 0.0931 no no no no no up d18:1-16:0-SM+blood 18:1/18:1-PC+blood 0 -0.50245098 0 serum_phospholipids serum_phospholipids 0.14 1.34E-05 no no no no up up d18:1-16:0-SM+blood 18:1/18:1-PG+blood 0 0 0.584273504 serum_phospholipids serum_phospholipids 0.14 0.00352 no no no no up up d18:1-16:0-SM+blood 18:1/18:1-PI+blood 0 0 0.406495726 serum_phospholipids serum_phospholipids 0.14 0.111 no no no dn no no d18:1-16:0-SM+blood 18:1/18:2-PG+blood 0 0 0.507692308 serum_phospholipids serum_phospholipids 0.14 5.58E-07 no no no no up up d18:1-16:0-SM+blood 18:1/20:4-PE+blood 0.551879699 0 0 serum_phospholipids serum_phospholipids 0.14 0.0578 no no no up no no d18:1-16:0-SM+blood 18:1/22:6-PE+blood 0.469172932 0 -0.406495726 serum_phospholipids serum_phospholipids 0.14 0.0047 no no no no up no d18:1-16:0-SM+blood 18:2/18:2-PS+blood 0 0 0.496752137 serum_phospholipids serum_phospholipids 0.14 0.00674 no no no up up no d18:1-16:0-SM+blood 18:3n6+blood 0 0 0.421538462 serum_phospholipids serum_fattyacid 0.14 0.0463 no no no up no dn d18:1-16:0-SM+blood 20:0/20:4-PE+blood 0.545864662 0 0 serum_phospholipids serum_phospholipids 0.14 0.00128 no no no up up no d18:1-16:0-SM+blood 20:1/20:4-PC+blood -0.512781955 0 -0.489230769 serum_phospholipids serum_phospholipids 0.14 0.0419 no no no no no up d18:1-16:0-SM+blood 20:1/20:4-PE+blood 0.751879699 0 0 serum_phospholipids serum_phospholipids 0.14 0.0042 no no no up up no d18:1-16:0-SM+blood 20:2/18:3-PE+blood 0.670676692 0 0 serum_phospholipids serum_phospholipids 0.14 0.0391 no no no up up no d18:1-16:0-SM+blood 20:4-LPC+blood 0 0.566176471 0.496068376 serum_phospholipids serum_phospholipids 0.14 0.949 no no no no no no d18:1-16:0-SM+blood 20:4-LPE+blood 0.508270677 0 0 serum_phospholipids serum_phospholipids 0.14 0.552 no no no no no no d18:1-16:0-SM+blood 20:4/18:0-PE+blood 0.481203008 0 0 serum_phospholipids serum_phospholipids 0.14 0.000755 no no no up up no d18:1-16:0-SM+blood 20:4n6+blood 0.545864662 0 0 serum_phospholipids serum_fattyacid 0.14 0.133 no no no no no no d18:1-16:0-SM+blood 20:5/18:0-PC+blood 0 0 -0.606837607 serum_phospholipids serum_phospholipids 0.14 3.97E-06 no no no no up up d18:1-16:0-SM+blood 8-HETE+blood 0.509774436 0 0 serum_phospholipids serum_ARA 0.14 0.741 no no no no no no d18:1-16:0-SM+blood Aldosterone synthesis and secretion 0 0 0.413846154 serum_phospholipids kegg 0.14 NA no no no no up up d18:1-16:0-SM+blood Amphetamine addiction 0 0 0.417692308 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Antigen processing and presentation 0 -0.647058824 0 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Calcium signaling pathway 0 0 0.436153846 serum_phospholipids kegg 0.14 NA no no no no up up d18:1-16:0-SM+blood Chemical carcinogenesis - receptor activation 0 0.517647059 0 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Choline metabolism in cancer 0 0.517647059 0 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Clostridium -0.464836438 0 0 serum_phospholipids Genus 0.14 0.925 no no no no no no d18:1-16:0-SM+blood Cocaine addiction 0 0 0.437692308 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood d18:0-16:0-SM+blood 0.993984962 0.987745098 0.984957265 serum_phospholipids serum_phospholipids 0.14 0.202 no no no no no no d18:1-16:0-SM+blood d18:0-18:3-SM+blood 0.733834586 0 0.535042735 serum_phospholipids serum_phospholipids 0.14 0.0879 no no no no dn no d18:1-16:0-SM+blood d18:0-24:1-SM+blood 0.753383459 0 0.528888889 serum_phospholipids serum_phospholipids 0.14 0.0609 no no no no dn dn d18:1-16:0-SM+blood d18:1-14:0-SM+blood 0 0 0.511794872 serum_phospholipids serum_phospholipids 0.14 0.94 no no no no no no d18:1-16:0-SM+blood d18:1-14:1-SM+blood 0 0 0.491965812 serum_phospholipids serum_phospholipids 0.14 0.0952 no no no no dn no d18:1-16:0-SM+blood Dopaminergic synapse 0 0 0.416153846 serum_phospholipids kegg 0.14 NA no no no no up no d18:1-16:0-SM+blood Endocrine resistance 0 0.517647059 0 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Epstein-Barr virus infection 0 -0.605882353 0 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood ErbB signaling pathway 0 0.5 0 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood FoxO signaling pathway 0 0 -0.400769231 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Gastric cancer -0.470175439 0 0 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood GDCA+stool 0.642857143 0 0 serum_phospholipids stool_bileacids 0.14 0.656 no no no no no no d18:1-16:0-SM+blood Gemmiger 0 0.503687024 0 butyrate-producing serum_phospholipids Genus 0.14 0.595 no no no no no no d18:1-16:0-SM+blood GnRH signaling pathway 0 0 0.424615385 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood "Growth hormone synthesis, secretion and action" 0 0.511764706 0 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Herpes simplex virus 1 infection 0 -0.635294118 0 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Human cytomegalovirus infection 0 -0.544117647 0 serum_phospholipids kegg 0.14 NA no no no no no dn d18:1-16:0-SM+blood Human immunodeficiency virus 1 infection 0 -0.564705882 0 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Human T-cell leukemia virus 1 infection 0 -0.620588235 0 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Long-term depression 0 0 0.411538462 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Longevity regulating pathway - multiple species 0 0 -0.433076923 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Malaria -0.489473684 0 0 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Mineral absorption -0.514035088 0 0 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Pancreatic secretion 0 0 0.420769231 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Peroxisome 0 0 -0.499230769 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood Signaling pathways regulating pluripotency of stem cells 0 0.517647059 0 serum_phospholipids kegg 0.14 NA no no no no no no d18:1-16:0-SM+blood TDCA+stool 0 -0.646686526 0 serum_phospholipids stool_bileacids 0.14 0.963 no no no no no no d18:1-16:1-SM+blood 14:0/18:2-PC+blood 0 0 0.444786325 serum_phospholipids serum_phospholipids 0.2 0.102 no no no no up no d18:1-16:1-SM+blood 14:0/20:4-PC+blood 0 0 0.628717949 serum_phospholipids serum_phospholipids 0.2 0.486 no no no no no no d18:1-16:1-SM+blood 14:1/18:2-PG+blood 0 0 0.477606838 serum_phospholipids serum_phospholipids 0.2 0.00259 no no no no up up d18:1-16:1-SM+blood 16:0-LPC+blood 0 0 0.454358974 serum_phospholipids serum_phospholipids 0.2 0.00456 no no no up up no d18:1-16:1-SM+blood 16:0/14:0-PC+blood -0.490225564 -0.485294118 0 serum_phospholipids serum_phospholipids 0.2 0.0206 no no no no up up d18:1-16:1-SM+blood 16:0/18:1-PC+blood 0 -0.68872549 -0.531623932 serum_phospholipids serum_phospholipids 0.2 6.15E-07 no no no up up up d18:1-16:1-SM+blood 16:0/18:2-PC+blood -0.643609023 -0.769607843 -0.824273504 serum_phospholipids serum_phospholipids 0.2 3.24E-06 no no no no up up d18:1-16:1-SM+blood 16:0/20:3-PC+blood -0.484210526 0 0 serum_phospholipids serum_phospholipids 0.2 5.43E-06 no no no no up up d18:1-16:1-SM+blood 16:0/20:4-PC+blood 0 0 -0.445470085 serum_phospholipids serum_phospholipids 0.2 0.0262 no no no no up no d18:1-16:1-SM+blood 16:0/22:6-PC+blood 0 0 -0.633504274 serum_phospholipids serum_phospholipids 0.2 4.53E-05 no no no no up up d18:1-16:1-SM+blood 16:0/22:6-PE+blood 0.493233083 0 0 serum_phospholipids serum_phospholipids 0.2 0.000934 no no no up up no d18:1-16:1-SM+blood 16:1/16:0-PC+blood -0.467669173 -0.485294118 -0.633504274 serum_phospholipids serum_phospholipids 0.2 0.0215 no no no no up up d18:1-16:1-SM+blood 18:0-LPC+blood 0 0.573529412 0 serum_phospholipids serum_phospholipids 0.2 0.554 no no no no no no d18:1-16:1-SM+blood 18:0-LPE+blood 0 0.482843137 0.429059829 serum_phospholipids serum_phospholipids 0.2 0.491 no no no no no no d18:1-16:1-SM+blood 18:0/16:0-PC+blood 0 -0.656862745 -0.536410256 serum_phospholipids serum_phospholipids 0.2 9.64E-07 no no no up up up d18:1-16:1-SM+blood 18:0/18:2-PC+blood -0.589473684 -0.566176471 -0.55965812 serum_phospholipids serum_phospholipids 0.2 1.74E-06 no no no no up up d18:1-16:1-SM+blood 18:0/22:6-PC+blood 0 0 -0.522735043 serum_phospholipids serum_phospholipids 0.2 0.0775 no no no no no up d18:1-16:1-SM+blood 18:1/16:0-PC+blood -0.62406015 -0.732843137 -0.822222222 serum_phospholipids serum_phospholipids 0.2 2.43E-05 no no no no up up d18:1-16:1-SM+blood 18:1/18:0-PC+blood -0.554887218 -0.56372549 -0.56991453 serum_phospholipids serum_phospholipids 0.2 1.83E-06 no no no no up up d18:1-16:1-SM+blood 18:1/20:4-PC+blood 0 0 -0.405128205 serum_phospholipids serum_phospholipids 0.2 0.582 no no no no no no d18:1-16:1-SM+blood 18:1/20:4-PE+blood 0.452631579 0 0 serum_phospholipids serum_phospholipids 0.2 0.0578 no no no up no no d18:1-16:1-SM+blood 18:1/22:6-PE+blood 0 0 -0.51042735 serum_phospholipids serum_phospholipids 0.2 0.0047 no no no no up no d18:1-16:1-SM+blood 18:2/16:0-PC+blood 0 -0.605392157 0 serum_phospholipids serum_phospholipids 0.2 8.67E-05 no no no no up up d18:1-16:1-SM+blood 18:3n6+blood 0 0 0.495384615 serum_phospholipids serum_fattyacid 0.2 0.0463 no no no up no dn d18:1-16:1-SM+blood 20:0-LPC+blood 0 0.551470588 0 serum_phospholipids serum_phospholipids 0.2 0.199 no no no no no no d18:1-16:1-SM+blood 20:0/20:4-PE+blood 0.482706767 0 0 serum_phospholipids serum_phospholipids 0.2 0.00128 no no no up up no d18:1-16:1-SM+blood 20:1/20:4-PC+blood -0.472180451 0 -0.55008547 serum_phospholipids serum_phospholipids 0.2 0.0419 no no no no no up d18:1-16:1-SM+blood 20:1/20:4-PE+blood 0.628571429 0 0 serum_phospholipids serum_phospholipids 0.2 0.0042 no no no up up no d18:1-16:1-SM+blood 20:2/18:1-PE+blood 0.485714286 0 0 serum_phospholipids serum_phospholipids 0.2 0.00208 no no no up up no d18:1-16:1-SM+blood 20:2/18:3-PE+blood 0.545864662 0 0 serum_phospholipids serum_phospholipids 0.2 0.0391 no no no up up no d18:1-16:1-SM+blood 20:3/16:0-PC+blood 0 0 -0.522051282 serum_phospholipids serum_phospholipids 0.2 0.00405 no no no no up up d18:1-16:1-SM+blood 20:5/18:0-PC+blood 0 0 -0.629401709 serum_phospholipids serum_phospholipids 0.2 3.97E-06 no no no no up up d18:1-16:1-SM+blood 22:0/16:0-PE+blood 0 -0.482843137 0 serum_phospholipids serum_phospholipids 0.2 0.091 no no no no no up d18:1-16:1-SM+blood 24:1+blood 0 -0.507352941 0 serum_phospholipids serum_fattyacid 0.2 0.00582 no no no no dn dn d18:1-16:1-SM+blood Adrenergic signaling in cardiomyocytes 0 0.576470588 0 serum_phospholipids kegg 0.2 NA no no no no no up d18:1-16:1-SM+blood Alcoholism 0 0 0.474615385 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Aldosterone synthesis and secretion 0 0 0.482307692 serum_phospholipids kegg 0.2 NA no no no no up up d18:1-16:1-SM+blood Alistipes 0 0.506437863 0 serum_phospholipids Genus 0.2 0.0114 no no no no up no d18:1-16:1-SM+blood Alzheimer disease 0 0 0.406153846 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Amphetamine addiction 0 0 0.439230769 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood AMPK signaling pathway -0.654385965 0.685294118 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Amyotrophic lateral sclerosis 0 0 0.467692308 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Blautia 0 0 0.42092872 acetate-producing serum_phospholipids Genus 0.2 1.36E-05 no no no up dn dn d18:1-16:1-SM+blood Calcium signaling pathway 0 0 0.422307692 serum_phospholipids kegg 0.2 NA no no no no up up d18:1-16:1-SM+blood capric acid C6+blood 0 0 -0.406495726 serum_phospholipids serum_scfa 0.2 0.433 no no no no no no d18:1-16:1-SM+blood Cardiac muscle contraction 0 0 0.456153846 serum_phospholipids kegg 0.2 NA no no no no no up d18:1-16:1-SM+blood Central carbon metabolism in cancer 0 0.717647059 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Circadian entrainment 0 0 0.405384615 serum_phospholipids kegg 0.2 NA no no no no up up d18:1-16:1-SM+blood Cocaine addiction 0 0 0.442307692 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Collinsella 0 -0.517889004 0 serum_phospholipids Genus 0.2 0.128 no no no no no no d18:1-16:1-SM+blood Cortisol synthesis and secretion 0 0 0.475384615 serum_phospholipids kegg 0.2 NA no no no no no up d18:1-16:1-SM+blood Creatinine+blood 0 0 -0.487179487 serum_phospholipids serum_choline 0.2 0.437 no no no no no no d18:1-16:1-SM+blood d18:0-16:0-SM+blood 0.796992481 0.671568627 0.721709402 serum_phospholipids serum_phospholipids 0.2 0.202 no no no no no no d18:1-16:1-SM+blood d18:0-18:3-SM+blood 0.762406015 0.666666667 0.820854701 serum_phospholipids serum_phospholipids 0.2 0.0879 no no no no dn no d18:1-16:1-SM+blood d18:0-24:1-SM+blood 0.612030075 0.62254902 0.539145299 serum_phospholipids serum_phospholipids 0.2 0.0609 no no no no dn dn d18:1-16:1-SM+blood d18:1-14:0-SM+blood 0.520300752 0.656862745 0.801709402 serum_phospholipids serum_phospholipids 0.2 0.94 no no no no no no d18:1-16:1-SM+blood d18:1-14:1-SM+blood 0.557894737 0.68627451 0.794871795 serum_phospholipids serum_phospholipids 0.2 0.0952 no no no no dn no d18:1-16:1-SM+blood d18:1-16:0-SM+blood 0.783458647 0.620098039 0.714871795 serum_phospholipids serum_phospholipids 0.2 0.14 no no no no no no d18:1-16:1-SM+blood Diabetic cardiomyopathy 0 0 0.424615385 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood EGFR tyrosine kinase inhibitor resistance 0 0.523529412 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Endocrine and other factor-regulated calcium reabsorption 0 0 0.450769231 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Faecalibacterium 0 -0.551470588 0 butyrate-producing serum_phospholipids Genus 0.2 0.0039 no no no no dn dn d18:1-16:1-SM+blood Fc gamma R-mediated phagocytosis 0.456140351 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Ferroptosis -0.515789474 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Gap junction -0.477192982 0 0.563846154 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Gastric cancer -0.464912281 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood GDCA+stool 0.736263736 0 0 serum_phospholipids stool_bileacids 0.2 0.656 no no no no no no d18:1-16:1-SM+blood GnRH signaling pathway 0 0 0.403846154 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Herpes simplex virus 1 infection 0 -0.502941176 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood HIF-1 signaling pathway -0.498245614 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Inflammatory mediator regulation of TRP channels 0 0 0.426153846 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Insulin secretion 0 0 0.451538462 yes serum_phospholipids kegg 0.2 NA no no no no up up d18:1-16:1-SM+blood Kaposi sarcoma-associated herpesvirus infection -0.512280702 0 0 serum_phospholipids kegg 0.2 NA no no no no no dn d18:1-16:1-SM+blood Lachnospira 0 0 -0.431507482 butyrate-producing serum_phospholipids Genus 0.2 0.279 no no no no no no d18:1-16:1-SM+blood Legionellosis 0 0.594117647 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Lipid and atherosclerosis 0.566666667 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Long-term depression 0 0 0.557692308 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Longevity regulating pathway -0.507017544 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Malaria -0.607017544 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Mineral absorption -0.631578947 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Mitophagy - animal -0.519298246 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Morphine addiction 0 0 0.495384615 serum_phospholipids kegg 0.2 NA no no no no up up d18:1-16:1-SM+blood mTOR signaling pathway 0 0.55 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Necroptosis -0.556140351 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Non-alcoholic fatty liver disease 0 0 0.529230769 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Olfactory transduction 0.524561404 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Osteoclast differentiation 0.464912281 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Oxidative phosphorylation 0 0 0.403846154 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Pancreatic secretion 0 0 0.513846154 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Phenylacetic acid+stool 0 0.618181818 0 serum_phospholipids stool_cometabolism 0.2 0.785 no no no no no no d18:1-16:1-SM+blood Proteasome 0 0 -0.580769231 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Purine metabolism -0.542105263 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Regulation of lipolysis in adipocytes 0 0 0.449230769 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood RNA transport 0 0.538235294 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Ruminococcus 0 0 0.412525909 serum_phospholipids Genus 0.2 0.0679 no no no no no dn d18:1-16:1-SM+blood Shigellosis -0.494736842 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Thermogenesis 0 0 0.409230769 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Thyroid hormone synthesis -0.619298246 0 0.435384615 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood Ubiquitin mediated proteolysis -0.473684211 0 0 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-16:1-SM+blood UDCA+stool 0 0 0.461654135 serum_phospholipids stool_bileacids 0.2 0.266 no no no no no no d18:1-16:1-SM+blood Vasopressin-regulated water reabsorption 0 0 0.507692308 serum_phospholipids kegg 0.2 NA no no no no no no d18:1-18:0-SM+blood 14:0-LPC+blood -0.476691729 -0.529411765 0 serum_phospholipids serum_phospholipids 0.97 0.00689 no no no up up no d18:1-18:0-SM+blood 14:0/16:0-PC+blood 0 -0.583333333 0 serum_phospholipids serum_phospholipids 0.97 0.0358 no no no no up no d18:1-18:0-SM+blood 14:0/18:0-PC+blood 0 -0.654411765 0 serum_phospholipids serum_phospholipids 0.97 0.00289 no no no up up no d18:1-18:0-SM+blood 16:0/16:0-PC+blood 0.527819549 0 0 serum_phospholipids serum_phospholipids 0.97 0.00079 no no no no up up d18:1-18:0-SM+blood 16:0/16:1-PC+blood 0 -0.639705882 0 serum_phospholipids serum_phospholipids 0.97 0.00283 no no no up up no d18:1-18:0-SM+blood 16:0/16:1-PI+blood -0.612030075 0 0 serum_phospholipids serum_phospholipids 0.97 0.262 no no no no no no d18:1-18:0-SM+blood 16:0/18:1-PC+blood 0.711278195 0 0 serum_phospholipids serum_phospholipids 0.97 6.15E-07 no no no up up up d18:1-18:0-SM+blood 16:0/18:2-PC+blood 0.539849624 0 0 serum_phospholipids serum_phospholipids 0.97 3.24E-06 no no no no up up d18:1-18:0-SM+blood 16:0/20:4-PC+blood 0.512781955 0 0 serum_phospholipids serum_phospholipids 0.97 0.0262 no no no no up no d18:1-18:0-SM+blood 16:0/20:4-PI+blood -0.496240602 0 0 serum_phospholipids serum_phospholipids 0.97 0.558 no no no no no no d18:1-18:0-SM+blood 16:0/20:5-PG+blood 0.520300752 0 0.435213675 serum_phospholipids serum_phospholipids 0.97 0.00656 no no no no up no d18:1-18:0-SM+blood 16:0/22:6-PC+blood 0 0.647058824 0 serum_phospholipids serum_phospholipids 0.97 4.53E-05 no no no no up up d18:1-18:0-SM+blood 16:1/16:0-PC+blood 0.721804511 0.666666667 0.413333333 serum_phospholipids serum_phospholipids 0.97 0.0215 no no no no up up d18:1-18:0-SM+blood 16:1/16:1-PC+blood 0.810526316 0 0 serum_phospholipids serum_phospholipids 0.97 0.0177 no no no no no up d18:1-18:0-SM+blood 16:1/18:1-PG+blood 0.521804511 0 0 serum_phospholipids serum_phospholipids 0.97 3.21E-05 no no no no up up d18:1-18:0-SM+blood 16:1/18:2-PG+blood 0.610526316 0 0.478290598 serum_phospholipids serum_phospholipids 0.97 1.40E-08 no no no no up up d18:1-18:0-SM+blood 18:0/16:0-PC+blood 0.763909774 0 0 serum_phospholipids serum_phospholipids 0.97 9.64E-07 no no no up up up d18:1-18:0-SM+blood 18:0/18:0-PE+blood -0.452631579 0 0 serum_phospholipids serum_phospholipids 0.97 0.00896 no no no up up no d18:1-18:0-SM+blood 18:0/18:0-PS+blood 0 0 0.414700855 serum_phospholipids serum_phospholipids 0.97 0.00617 no no no no up no d18:1-18:0-SM+blood 18:0/18:2-PC+blood 0.485714286 0 0 serum_phospholipids serum_phospholipids 0.97 1.74E-06 no no no no up up d18:1-18:0-SM+blood 18:0/20:2-PC+blood 0 0 -0.427692308 serum_phospholipids serum_phospholipids 0.97 0.733 no no no no no no d18:1-18:0-SM+blood 18:0/20:4-PC+blood 0.490225564 0.588235294 0 serum_phospholipids serum_phospholipids 0.97 0.454 no no no no no no d18:1-18:0-SM+blood 18:0/20:5-PC+blood 0 0.654411765 0 serum_phospholipids serum_phospholipids 0.97 0.17 no no no no no no d18:1-18:0-SM+blood 18:0/22:6-PC+blood 0 0.678921569 0 serum_phospholipids serum_phospholipids 0.97 0.0775 no no no no no up d18:1-18:0-SM+blood 18:0/22:6-PI+blood 0 0.487745098 0 serum_phospholipids serum_phospholipids 0.97 0.425 no no no no no no d18:1-18:0-SM+blood 18:1-LPE+blood -0.476691729 0 0 serum_phospholipids serum_phospholipids 0.97 0.117 no no no no no no d18:1-18:0-SM+blood 18:1/16:0-PC+blood 0.54887218 0 0 serum_phospholipids serum_phospholipids 0.97 2.43E-05 no no no no up up d18:1-18:0-SM+blood 18:1/16:0-PI+blood 0 -0.507352941 0 serum_phospholipids serum_phospholipids 0.97 0.793 no no no no no no d18:1-18:0-SM+blood 18:1/18:0-PC+blood 0.457142857 0 0 serum_phospholipids serum_phospholipids 0.97 1.83E-06 no no no no up up d18:1-18:0-SM+blood 18:1/18:0-PS+blood 0.612030075 0 0 serum_phospholipids serum_phospholipids 0.97 0.193 no no no no no no d18:1-18:0-SM+blood 18:1/18:1-PC+blood 0 -0.539215686 0 serum_phospholipids serum_phospholipids 0.97 1.34E-05 no no no no up up d18:1-18:0-SM+blood 18:1/18:2-PG+blood 0.517293233 0 0.513162393 serum_phospholipids serum_phospholipids 0.97 5.58E-07 no no no no up up d18:1-18:0-SM+blood 18:1/20:4-PC+blood 0.466165414 0.62745098 0 serum_phospholipids serum_phospholipids 0.97 0.582 no no no no no no d18:1-18:0-SM+blood 18:2/16:0-PC+blood 0.57443609 0 0 serum_phospholipids serum_phospholipids 0.97 8.67E-05 no no no no up up d18:1-18:0-SM+blood 18:2/18:2-PC+blood 0 -0.50245098 0 serum_phospholipids serum_phospholipids 0.97 1.98E-05 no no no dn up up d18:1-18:0-SM+blood 18:2/18:2-PS+blood 0 -0.514705882 0.414700855 serum_phospholipids serum_phospholipids 0.97 0.00674 no no no up up no d18:1-18:0-SM+blood 18:3n3+blood 0.509774436 0 0 serum_phospholipids serum_fattyacid 0.97 0.291 no no no no no no d18:1-18:0-SM+blood 20:0-LPC+blood 0 0 -0.422905983 serum_phospholipids serum_phospholipids 0.97 0.199 no no no no no no d18:1-18:0-SM+blood 20:0-LPE+blood 0 0 -0.417435897 serum_phospholipids serum_phospholipids 0.97 0.0615 no no no no no up d18:1-18:0-SM+blood 20:0/20:4-PE+blood 0 -0.522058824 0 serum_phospholipids serum_phospholipids 0.97 0.00128 no no no up up no d18:1-18:0-SM+blood 20:0/20:5-PC+blood 0.603007519 0.620098039 0 serum_phospholipids serum_phospholipids 0.97 0.882 no no no no no no d18:1-18:0-SM+blood 20:1-LPE+blood 0 0 -0.44 serum_phospholipids serum_phospholipids 0.97 0.465 no no no no no no d18:1-18:0-SM+blood 20:1/20:4-PC+blood 0 0.649509804 0 serum_phospholipids serum_phospholipids 0.97 0.0419 no no no no no up d18:1-18:0-SM+blood 20:1/20:4-PE+blood 0.470676692 0 0 serum_phospholipids serum_phospholipids 0.97 0.0042 no no no up up no d18:1-18:0-SM+blood 20:1+blood 0 0 -0.407863248 yes serum_phospholipids serum_fattyacid 0.97 2.56E-05 no no no dn dn dn d18:1-18:0-SM+blood 20:2+blood 0 -0.524509804 0 serum_phospholipids serum_fattyacid 0.97 0.478 no no no no no no d18:1-18:0-SM+blood 20:3/16:0-PC+blood 0.544360902 0 0 serum_phospholipids serum_phospholipids 0.97 0.00405 no no no no up up d18:1-18:0-SM+blood 20:3/18:0-PC+blood 0.45112782 0.549019608 0 serum_phospholipids serum_phospholipids 0.97 0.296 no no no no no no d18:1-18:0-SM+blood 20:3n6+blood -0.476691729 -0.585784314 0 serum_phospholipids serum_fattyacid 0.97 0.0884 no no no up no no d18:1-18:0-SM+blood 20:4-LPC+blood 0 0.539215686 0 serum_phospholipids serum_phospholipids 0.97 0.949 no no no no no no d18:1-18:0-SM+blood 20:4n6+blood 0.445112782 0 0 serum_phospholipids serum_fattyacid 0.97 0.133 no no no no no no d18:1-18:0-SM+blood 20:5/18:0-PC+blood 0 0.585784314 0 serum_phospholipids serum_phospholipids 0.97 3.97E-06 no no no no up up d18:1-18:0-SM+blood 22:1-LPA+blood 0 0 -0.463931624 serum_phospholipids serum_phospholipids 0.97 0.00373 no no no no up up d18:1-18:0-SM+blood 22:6-LPC+blood 0 0.784313725 0 serum_phospholipids serum_phospholipids 0.97 0.127 no no no no no up d18:1-18:0-SM+blood 22:6n3+blood 0 0.495098039 0 serum_phospholipids serum_fattyacid 0.97 0.792 no no no no no no d18:1-18:0-SM+blood AA+blood 0.661654135 0 0 serum_phospholipids serum_ARA 0.97 0.212 no no no no no no d18:1-18:0-SM+blood Bacteroides 0 0.512254902 0 LPS-producing serum_phospholipids Genus 0.97 0.000267 no no no dn dn up d18:1-18:0-SM+blood Blautia 0 0.522058824 0 acetate-producing serum_phospholipids Genus 0.97 1.36E-05 no no no up dn dn d18:1-18:0-SM+blood CDCA+blood -0.541353383 0 0 serum_phospholipids serum_bileacids 0.97 0.506 no no no no no no d18:1-18:0-SM+blood cGMP-PKG signaling pathway 0 0 0.476923077 serum_phospholipids kegg 0.97 NA no no no no no no d18:1-18:0-SM+blood d18:0-18:3-SM+blood 0.494736842 0 0 serum_phospholipids serum_phospholipids 0.97 0.0879 no no no no dn no d18:1-18:0-SM+blood Epstein-Barr virus infection 0 -0.544117647 0 serum_phospholipids kegg 0.97 NA no no no no no no d18:1-18:0-SM+blood Human cytomegalovirus infection 0 -0.517647059 0 serum_phospholipids kegg 0.97 NA no no no no no dn d18:1-18:0-SM+blood Human immunodeficiency virus 1 infection 0 -0.511764706 0 serum_phospholipids kegg 0.97 NA no no no no no no d18:1-18:0-SM+blood Human T-cell leukemia virus 1 infection 0 -0.520588235 0 serum_phospholipids kegg 0.97 NA no no no no no no d18:1-18:0-SM+blood Longevity regulating pathway -0.464912281 0 0 serum_phospholipids kegg 0.97 NA no no no no no no d18:1-18:0-SM+blood Mineral absorption -0.547368421 0 0 serum_phospholipids kegg 0.97 NA no no no no no no d18:1-18:0-SM+blood Mitophagy - animal -0.496491228 0 0 serum_phospholipids kegg 0.97 NA no no no no no no d18:1-18:0-SM+blood Necroptosis -0.512280702 0 0 serum_phospholipids kegg 0.97 NA no no no no no no d18:1-18:0-SM+blood Salmonella infection 0.554385965 0 0 serum_phospholipids kegg 0.97 NA no no no no no no d18:1-18:0-SM+blood Slackia 0 0 -0.402933181 serum_phospholipids Genus 0.97 0.94 no no no no no no d18:1-18:1-SM+blood 11-HETE+blood 0 -0.507615708 0 serum_phospholipids serum_ARA 0.916 0.464 no no no no no no d18:1-18:1-SM+blood 13-HODE+blood 0 0 -0.55008547 serum_phospholipids serum_ARA 0.916 0.32 no no no no no no d18:1-18:1-SM+blood 14:0-LPC+blood -0.610526316 0 0 serum_phospholipids serum_phospholipids 0.916 0.00689 no no no up up no d18:1-18:1-SM+blood 14:0/16:0-PC+blood 0 -0.56127451 0 serum_phospholipids serum_phospholipids 0.916 0.0358 no no no no up no d18:1-18:1-SM+blood 14:0/18:0-PC+blood 0 -0.546568627 0 serum_phospholipids serum_phospholipids 0.916 0.00289 no no no up up no d18:1-18:1-SM+blood 15-HETE+blood 0 0 0.436744232 serum_phospholipids serum_ARA 0.916 0.819 no no no no no no d18:1-18:1-SM+blood 16:0-LPC+blood 0 0.490196078 0 serum_phospholipids serum_phospholipids 0.916 0.00456 no no no up up no d18:1-18:1-SM+blood 16:0/16:1-PC+blood 0 -0.553921569 0 serum_phospholipids serum_phospholipids 0.916 0.00283 no no no up up no d18:1-18:1-SM+blood 16:0/16:1-PI+blood -0.595488722 0 0 serum_phospholipids serum_phospholipids 0.916 0.262 no no no no no no d18:1-18:1-SM+blood 16:0/18:0-PS+blood 0 0 0.413333333 serum_phospholipids serum_phospholipids 0.916 0.377 no no no no no no d18:1-18:1-SM+blood 16:0/18:1-PC+blood 0.545864662 0 0 serum_phospholipids serum_phospholipids 0.916 6.15E-07 no no no up up up d18:1-18:1-SM+blood 16:0/18:2-PI+blood -0.521804511 0 0 serum_phospholipids serum_phospholipids 0.916 0.269 no no no no no no d18:1-18:1-SM+blood 16:0/20:3-PC+blood 0 -0.600490196 0 serum_phospholipids serum_phospholipids 0.916 5.43E-06 no no no no up up d18:1-18:1-SM+blood 16:0/20:4-PI+blood -0.458646617 0 0 serum_phospholipids serum_phospholipids 0.916 0.558 no no no no no no d18:1-18:1-SM+blood 16:0/20:5-PG+blood 0.682706767 0 0.521367521 serum_phospholipids serum_phospholipids 0.916 0.00656 no no no no up no d18:1-18:1-SM+blood 16:1-LPC+blood 0 0.617647059 0 serum_phospholipids serum_phospholipids 0.916 0.0241 no no no no up no d18:1-18:1-SM+blood 16:1/16:0-PC+blood 0.467669173 0 0 serum_phospholipids serum_phospholipids 0.916 0.0215 no no no no up up d18:1-18:1-SM+blood 16:1/16:1-PC+blood 0.763909774 0 0.401025641 serum_phospholipids serum_phospholipids 0.916 0.0177 no no no no no up d18:1-18:1-SM+blood 16:1/18:1-PG+blood 0.587969925 0 0.456410256 serum_phospholipids serum_phospholipids 0.916 3.21E-05 no no no no up up d18:1-18:1-SM+blood 16:1/18:2-PG+blood 0.527819549 0 0.439316239 serum_phospholipids serum_phospholipids 0.916 1.40E-08 no no no no up up d18:1-18:1-SM+blood 18:0/16:0-PC+blood 0.601503759 0 0 serum_phospholipids serum_phospholipids 0.916 9.64E-07 no no no up up up d18:1-18:1-SM+blood 18:0/20:4-PC+blood 0.481203008 0 0 serum_phospholipids serum_phospholipids 0.916 0.454 no no no no no no d18:1-18:1-SM+blood 18:0/20:4-PI+blood 0.527819549 0 0 serum_phospholipids serum_phospholipids 0.916 0.167 no no no no no no d18:1-18:1-SM+blood 18:1/18:0-PS+blood 0.684210526 0 0 serum_phospholipids serum_phospholipids 0.916 0.193 no no no no no no d18:1-18:1-SM+blood 18:1/18:1-PC+blood 0 -0.671568627 0 serum_phospholipids serum_phospholipids 0.916 1.34E-05 no no no no up up d18:1-18:1-SM+blood 18:1/18:1-PG+blood 0 -0.517156863 0 serum_phospholipids serum_phospholipids 0.916 0.00352 no no no no up up d18:1-18:1-SM+blood 18:1/18:2-PG+blood 0 0 0.45025641 serum_phospholipids serum_phospholipids 0.916 5.58E-07 no no no no up up d18:1-18:1-SM+blood 18:1/20:4-PC+blood 0.580451128 0.487745098 0 serum_phospholipids serum_phospholipids 0.916 0.582 no no no no no no d18:1-18:1-SM+blood 18:1/20:4-PE+blood 0.538345865 0 0 serum_phospholipids serum_phospholipids 0.916 0.0578 no no no up no no d18:1-18:1-SM+blood 18:2-LPE+blood -0.511278195 0 0 serum_phospholipids serum_phospholipids 0.916 0.112 no no no no no no d18:1-18:1-SM+blood 18:2/18:2-PS+blood 0 0 0.466666667 serum_phospholipids serum_phospholipids 0.916 0.00674 no no no up up no d18:1-18:1-SM+blood 18:3n6+blood 0 0 0.40034188 serum_phospholipids serum_fattyacid 0.916 0.0463 no no no up no dn d18:1-18:1-SM+blood 20:0-LPC+blood 0 0 -0.428376068 serum_phospholipids serum_phospholipids 0.916 0.199 no no no no no no d18:1-18:1-SM+blood 20:0/20:5-PC+blood 0.744360902 0.539215686 0 serum_phospholipids serum_phospholipids 0.916 0.882 no no no no no no d18:1-18:1-SM+blood 20:1/20:4-PE+blood 0.702255639 0 0 serum_phospholipids serum_phospholipids 0.916 0.0042 no no no up up no d18:1-18:1-SM+blood 20:2/18:3-PE+blood 0.544360902 0 0 serum_phospholipids serum_phospholipids 0.916 0.0391 no no no up up no d18:1-18:1-SM+blood 20:3/18:0-PC+blood 0.446616541 0 0 serum_phospholipids serum_phospholipids 0.916 0.296 no no no no no no d18:1-18:1-SM+blood 20:3/18:0-PI+blood 0.476691729 0 0 serum_phospholipids serum_phospholipids 0.916 0.289 no no no no no no d18:1-18:1-SM+blood 20:3n6+blood -0.473684211 -0.544117647 0 serum_phospholipids serum_fattyacid 0.916 0.0884 no no no up no no d18:1-18:1-SM+blood 20:4-LPE+blood 0.539849624 0 0 serum_phospholipids serum_phospholipids 0.916 0.552 no no no no no no d18:1-18:1-SM+blood 20:4/18:0-PE+blood 0.493233083 0 0 serum_phospholipids serum_phospholipids 0.916 0.000755 no no no up up no d18:1-18:1-SM+blood 20:4n6+blood 0.663157895 0 0 serum_phospholipids serum_fattyacid 0.916 0.133 no no no no no no d18:1-18:1-SM+blood 22:6-LPC+blood 0 0.546568627 0 serum_phospholipids serum_phospholipids 0.916 0.127 no no no no no up d18:1-18:1-SM+blood 8-HETE+blood 0.466165414 0 -0.505641026 serum_phospholipids serum_ARA 0.916 0.741 no no no no no no d18:1-18:1-SM+blood AA+blood 0.530827068 0 0 serum_phospholipids serum_ARA 0.916 0.212 no no no no no no d18:1-18:1-SM+blood acetic acid C2+blood 0 0.558823529 0 serum_phospholipids serum_scfa 0.916 0.000193 no no no up dn no d18:1-18:1-SM+blood Alcoholism 0 0 0.562307692 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Antigen processing and presentation 0.505263158 0 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Bifidobacterium 0 0 0.44093662 acetate-producing serum_phospholipids Genus 0.916 0.105 no no no no dn no d18:1-18:1-SM+blood CDCA+blood -0.52481203 0 0 serum_phospholipids serum_bileacids 0.916 0.506 no no no no no no d18:1-18:1-SM+blood Circadian entrainment 0 0 0.477692308 serum_phospholipids kegg 0.916 NA no no no no up up d18:1-18:1-SM+blood Cushing syndrome -0.492982456 0 0 serum_phospholipids kegg 0.916 NA no no no no no up d18:1-18:1-SM+blood d18:0-16:0-SM+blood 0.601503759 0.620098039 0.44 serum_phospholipids serum_phospholipids 0.916 0.202 no no no no no no d18:1-18:1-SM+blood d18:0-18:3-SM+blood 0.723308271 0.681372549 0.572649573 serum_phospholipids serum_phospholipids 0.916 0.0879 no no no no dn no d18:1-18:1-SM+blood d18:1-14:1-SM+blood 0 0 0.459145299 serum_phospholipids serum_phospholipids 0.916 0.0952 no no no no dn no d18:1-18:1-SM+blood d18:1-16:0-SM+blood 0.630075188 0.588235294 0.470769231 serum_phospholipids serum_phospholipids 0.916 0.14 no no no no no no d18:1-18:1-SM+blood d18:1-16:1-SM+blood 0 0 0.498803419 serum_phospholipids serum_phospholipids 0.916 0.2 no no no no no no d18:1-18:1-SM+blood d18:1-18:0-SM+blood 0.882706767 0.791666667 0.758632479 serum_phospholipids serum_phospholipids 0.916 0.97 no no no no no no d18:1-18:1-SM+blood Dopaminergic synapse 0 0 0.402307692 serum_phospholipids kegg 0.916 NA no no no no up no d18:1-18:1-SM+blood EGFR tyrosine kinase inhibitor resistance -0.480701754 0 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Epstein-Barr virus infection 0 -0.570588235 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood FoxO signaling pathway 0 0 -0.402307692 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Fusobacterium 0 0.494197275 0 serum_phospholipids Genus 0.916 0.628 no no no no no no d18:1-18:1-SM+blood Gap junction 0 0 0.429230769 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Glutamatergic synapse 0 0 0.409230769 serum_phospholipids kegg 0.916 NA no no no no up up d18:1-18:1-SM+blood Herpes simplex virus 1 infection 0 -0.626470588 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Human cytomegalovirus infection 0 -0.529411765 0 serum_phospholipids kegg 0.916 NA no no no no no dn d18:1-18:1-SM+blood Human immunodeficiency virus 1 infection 0 -0.552941176 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Human T-cell leukemia virus 1 infection 0 -0.552941176 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Intestinal immune network for IgA production 0 -0.520588235 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood JAK-STAT signaling pathway 0 0 -0.464615385 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Kaposi sarcoma-associated herpesvirus infection -0.478947368 0 0 serum_phospholipids kegg 0.916 NA no no no no no dn d18:1-18:1-SM+blood Lipid and atherosclerosis 0.473684211 0 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Long-term depression 0 0 0.405384615 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Longevity regulating pathway -0.478947368 0 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Mineral absorption -0.694736842 0 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Mitophagy - animal -0.647368421 0 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Morphine addiction 0 0 0.456923077 serum_phospholipids kegg 0.916 NA no no no no up up d18:1-18:1-SM+blood mTOR signaling pathway -0.533333333 0 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Necroptosis -0.638596491 0 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Propionic acid+stool 0 0.627272727 0 yes serum_phospholipids stool_scfa 0.916 0.0436 no no no dn no up d18:1-18:1-SM+blood Salmonella infection 0.526315789 0 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Serotonergic synapse 0 0 0.45 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Shigellosis -0.471929825 0 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Slackia 0 0 -0.44367365 serum_phospholipids Genus 0.916 0.94 no no no no no no d18:1-18:1-SM+blood Ubiquitin mediated proteolysis -0.584210526 0 0 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-18:1-SM+blood Vascular smooth muscle contraction 0 0 0.471538462 serum_phospholipids kegg 0.916 NA no no no no no no d18:1-20:0-SM+blood 11-HETE+blood 0 -0.570709186 0 serum_phospholipids serum_ARA 0.933 0.464 no no no no no no d18:1-20:0-SM+blood "12,13-EPOME+blood" 0 -0.579976497 0 serum_phospholipids serum_ARA 0.933 0.901 no no no no no no d18:1-20:0-SM+blood 14:0-LPC+blood 0 0 0.40034188 serum_phospholipids serum_phospholipids 0.933 0.00689 no no no up up no d18:1-20:0-SM+blood 14:0/18:2-PC+blood 0 0 0.461880342 serum_phospholipids serum_phospholipids 0.933 0.102 no no no no up no d18:1-20:0-SM+blood 14:0/20:4-PC+blood 0 0 0.501538462 serum_phospholipids serum_phospholipids 0.933 0.486 no no no no no no d18:1-20:0-SM+blood 14:1/18:2-PG+blood 0 0 0.463931624 serum_phospholipids serum_phospholipids 0.933 0.00259 no no no no up up d18:1-20:0-SM+blood 16:0-LPC+blood 0 0 0.646495726 serum_phospholipids serum_phospholipids 0.933 0.00456 no no no up up no d18:1-20:0-SM+blood 16:0/14:0-PC+blood 0 0 -0.419487179 serum_phospholipids serum_phospholipids 0.933 0.0206 no no no no up up d18:1-20:0-SM+blood 16:0/18:0-PC+blood 0 0 0.401709402 serum_phospholipids serum_phospholipids 0.933 0.521 no no no no no no d18:1-20:0-SM+blood 16:0/18:1-PE+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.933 0.000107 no no no up up no d18:1-20:0-SM+blood 16:0/18:2-PC+blood 0 0 -0.602051282 serum_phospholipids serum_phospholipids 0.933 3.24E-06 no no no no up up d18:1-20:0-SM+blood 16:0/18:3-PC+blood 0.517293233 0 0 serum_phospholipids serum_phospholipids 0.933 0.00216 no no no no up up d18:1-20:0-SM+blood 16:0/20:4-PC+blood 0 0 -0.428376068 serum_phospholipids serum_phospholipids 0.933 0.0262 no no no no up no d18:1-20:0-SM+blood 16:1/16:0-PC+blood 0 0 -0.558974359 serum_phospholipids serum_phospholipids 0.933 0.0215 no no no no up up d18:1-20:0-SM+blood 18:0-LPC+blood 0 0 0.47965812 serum_phospholipids serum_phospholipids 0.933 0.554 no no no no no no d18:1-20:0-SM+blood 18:0/18:0-PE+blood 0 0 0.424957265 serum_phospholipids serum_phospholipids 0.933 0.00896 no no no up up no d18:1-20:0-SM+blood 18:0/20:2-PC+blood 0 0 0.455042735 serum_phospholipids serum_phospholipids 0.933 0.733 no no no no no no d18:1-20:0-SM+blood 18:0/20:4-PC+blood 0 0.544117647 0 serum_phospholipids serum_phospholipids 0.933 0.454 no no no no no no d18:1-20:0-SM+blood 18:0/20:5-PC+blood 0 0.536764706 0 serum_phospholipids serum_phospholipids 0.933 0.17 no no no no no no d18:1-20:0-SM+blood 18:1/16:0-PC+blood 0 0 -0.606153846 serum_phospholipids serum_phospholipids 0.933 2.43E-05 no no no no up up d18:1-20:0-SM+blood 18:1/16:1-PE+blood 0 -0.517156863 0 serum_phospholipids serum_phospholipids 0.933 0.000184 no no no up up no d18:1-20:0-SM+blood 18:1/18:0-PE+blood 0 -0.512254902 0 serum_phospholipids serum_phospholipids 0.933 1.39E-06 no no no up up no d18:1-20:0-SM+blood 18:1/18:1-PC+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.933 1.34E-05 no no no no up up d18:1-20:0-SM+blood 18:1/18:1-PE+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.933 1.03E-05 no no no up up no d18:1-20:0-SM+blood 18:1/20:4-PC+blood 0 0.573529412 0 serum_phospholipids serum_phospholipids 0.933 0.582 no no no no no no d18:1-20:0-SM+blood 18:1/20:4-PE+blood 0.497744361 0 0 serum_phospholipids serum_phospholipids 0.933 0.0578 no no no up no no d18:1-20:0-SM+blood 18:2-LPE+blood 0 -0.482843137 0 serum_phospholipids serum_phospholipids 0.933 0.112 no no no no no no d18:1-20:0-SM+blood 18:2n6c+blood 0 -0.495098039 0 serum_phospholipids serum_fattyacid 0.933 0.15 no no no no no no d18:1-20:0-SM+blood 18:3/18:2-PC+blood 0.478195489 0 0 serum_phospholipids serum_phospholipids 0.933 0.0394 no no no no no up d18:1-20:0-SM+blood 20:0-LPC+blood 0 0 0.594529915 serum_phospholipids serum_phospholipids 0.933 0.199 no no no no no no d18:1-20:0-SM+blood 20:0/20:5-PC+blood 0 0.68627451 0 serum_phospholipids serum_phospholipids 0.933 0.882 no no no no no no d18:1-20:0-SM+blood 20:1/20:4-PE+blood 0.556390977 0 0 serum_phospholipids serum_phospholipids 0.933 0.0042 no no no up up no d18:1-20:0-SM+blood 20:2+blood 0 -0.529411765 0 serum_phospholipids serum_fattyacid 0.933 0.478 no no no no no no d18:1-20:0-SM+blood 20:3/16:0-PC+blood 0 0 -0.462564103 serum_phospholipids serum_phospholipids 0.933 0.00405 no no no no up up d18:1-20:0-SM+blood 20:4-LPC+blood 0 0.578431373 0 serum_phospholipids serum_phospholipids 0.933 0.949 no no no no no no d18:1-20:0-SM+blood 24:0+blood 0.545864662 0 0 serum_phospholipids serum_fattyacid 0.933 0.034 no no no dn no up d18:1-20:0-SM+blood 8-HETE+blood 0.463157895 0 0 serum_phospholipids serum_ARA 0.933 0.741 no no no no no no d18:1-20:0-SM+blood Acute myeloid leukemia -0.461403509 0 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Antigen processing and presentation 0.642105263 -0.573529412 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Bacteroides 0 0.487745098 0 LPS-producing serum_phospholipids Genus 0.933 0.000267 no no no dn dn up d18:1-20:0-SM+blood Collinsella 0 -0.489528416 0 serum_phospholipids Genus 0.933 0.128 no no no no no no d18:1-20:0-SM+blood d18:0-16:0-SM+blood 0.693233083 0.796568627 0.548034188 serum_phospholipids serum_phospholipids 0.933 0.202 no no no no no no d18:1-20:0-SM+blood d18:0-18:3-SM+blood 0.813533835 0.669117647 0.503589744 serum_phospholipids serum_phospholipids 0.933 0.0879 no no no no dn no d18:1-20:0-SM+blood d18:0-24:1-SM+blood 0 0.549019608 0.45982906 serum_phospholipids serum_phospholipids 0.933 0.0609 no no no no dn dn d18:1-20:0-SM+blood d18:1-14:0-SM+blood 0.547368421 0.661764706 0.730598291 serum_phospholipids serum_phospholipids 0.933 0.94 no no no no no no d18:1-20:0-SM+blood d18:1-14:1-SM+blood 0.618045113 0.580882353 0.481025641 serum_phospholipids serum_phospholipids 0.933 0.0952 no no no no dn no d18:1-20:0-SM+blood d18:1-16:0-SM+blood 0.697744361 0.781862745 0.515213675 serum_phospholipids serum_phospholipids 0.933 0.14 no no no no no no d18:1-20:0-SM+blood d18:1-16:1-SM+blood 0.634586466 0.676470588 0.633504274 serum_phospholipids serum_phospholipids 0.933 0.2 no no no no no no d18:1-20:0-SM+blood d18:1-18:0-SM+blood 0.467669173 0.578431373 0 serum_phospholipids serum_phospholipids 0.933 0.97 no no no no no no d18:1-20:0-SM+blood d18:1-18:1-SM+blood 0.633082707 0.664215686 0 serum_phospholipids serum_phospholipids 0.933 0.916 no no no no no no d18:1-20:0-SM+blood Dorea 0 0 0.503948077 serum_phospholipids Genus 0.933 0.00362 no no no up no dn d18:1-20:0-SM+blood Epstein-Barr virus infection 0.5 -0.655882353 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Ferroptosis -0.535087719 0 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Gastric cancer -0.549122807 0 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood GDCA+stool 0.598901099 0 0 serum_phospholipids stool_bileacids 0.933 0.656 no no no no no no d18:1-20:0-SM+blood "Growth hormone synthesis, secretion and action" -0.489473684 0 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood HCA+stool 0.653846154 0 0 serum_phospholipids stool_bileacids 0.933 0.155 no no no no no no d18:1-20:0-SM+blood Herpes simplex virus 1 infection 0.571929825 -0.655882353 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Human cytomegalovirus infection 0.540350877 -0.644117647 0 serum_phospholipids kegg 0.933 NA no no no no no dn d18:1-20:0-SM+blood Human immunodeficiency virus 1 infection 0.526315789 -0.641176471 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Human T-cell leukemia virus 1 infection 0.649122807 -0.644117647 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Leishmaniasis 0.505263158 0 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Long-term depression -0.461403509 0 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Longevity regulating pathway -0.696491228 0 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood MAPK signaling pathway 0 0 -0.425384615 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Mineral absorption -0.736842105 0 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Mitophagy - animal -0.563157895 0 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Necroptosis -0.71754386 0 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood nutriCA+stool 0.664835165 0 0 serum_phospholipids stool_bileacids 0.933 0.481 no no no no no no d18:1-20:0-SM+blood Paraprevotella 0.481179359 0 0.408895201 serum_phospholipids Genus 0.933 0.118 no no no no no no d18:1-20:0-SM+blood Pathways of neurodegeneration - multiple diseases 0 0 0.446153846 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Pertussis 0.468421053 0 0 serum_phospholipids kegg 0.933 NA no no no no no dn d18:1-20:0-SM+blood Phenylacetic acid+stool 0 0.627272727 0 serum_phospholipids stool_cometabolism 0.933 0.785 no no no no no no d18:1-20:0-SM+blood Prolactin signaling pathway 0 0 -0.41 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Regulation of actin cytoskeleton 0.489473684 0 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Salmonella infection 0.580701754 0 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood TCA+stool 0 -0.636363636 0 serum_phospholipids stool_bileacids 0.933 0.458 no no no no no no d18:1-20:0-SM+blood Thyroid hormone synthesis 0 0 0.448461538 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:0-SM+blood Ubiquitin mediated proteolysis -0.48245614 0 0 serum_phospholipids kegg 0.933 NA no no no no no no d18:1-20:1-SM+blood 11-HETE+blood 0 -0.745650193 0 serum_phospholipids serum_ARA 0.0992 0.464 no no no no no no d18:1-20:1-SM+blood "12,13-EPOME+blood" 0 -0.529870536 0 serum_phospholipids serum_ARA 0.0992 0.901 no no no no no no d18:1-20:1-SM+blood 13-HODE+blood 0 0 -0.436581197 serum_phospholipids serum_ARA 0.0992 0.32 no no no no no no d18:1-20:1-SM+blood 14:0/16:0-PC+blood 0 -0.75 0 serum_phospholipids serum_phospholipids 0.0992 0.0358 no no no no up no d18:1-20:1-SM+blood 14:0/18:0-PC+blood 0 -0.725490196 0 serum_phospholipids serum_phospholipids 0.0992 0.00289 no no no up up no d18:1-20:1-SM+blood 14:0+blood 0 -0.56127451 0 yes serum_phospholipids serum_fattyacid 0.0992 0.00572 no no no up no dn d18:1-20:1-SM+blood 16:0/16:1-PC+blood 0 -0.754901961 0 serum_phospholipids serum_phospholipids 0.0992 0.00283 no no no up up no d18:1-20:1-SM+blood 16:0/16:1-PI+blood -0.587969925 -0.549019608 0 serum_phospholipids serum_phospholipids 0.0992 0.262 no no no no no no d18:1-20:1-SM+blood 16:0/18:1-PE+blood 0 -0.514705882 0 serum_phospholipids serum_phospholipids 0.0992 0.000107 no no no up up no d18:1-20:1-SM+blood 16:0/18:2-PI+blood -0.461654135 0 0 serum_phospholipids serum_phospholipids 0.0992 0.269 no no no no no no d18:1-20:1-SM+blood 16:0/20:4-PI+blood -0.514285714 0 0 serum_phospholipids serum_phospholipids 0.0992 0.558 no no no no no no d18:1-20:1-SM+blood 16:0/20:5-PG+blood 0.454135338 0 0.478974359 serum_phospholipids serum_phospholipids 0.0992 0.00656 no no no no up no d18:1-20:1-SM+blood 16:1/16:1-PC+blood 0.506766917 0 0 serum_phospholipids serum_phospholipids 0.0992 0.0177 no no no no no up d18:1-20:1-SM+blood 16:1/18:2-PG+blood 0.553383459 0 0 serum_phospholipids serum_phospholipids 0.0992 1.40E-08 no no no no up up d18:1-20:1-SM+blood 18:0/16:0-PC+blood 0.448120301 0 0 serum_phospholipids serum_phospholipids 0.0992 9.64E-07 no no no up up up d18:1-20:1-SM+blood 18:0/18:0-PE+blood 0 -0.519607843 0 serum_phospholipids serum_phospholipids 0.0992 0.00896 no no no up up no d18:1-20:1-SM+blood 18:0/18:1-PE+blood 0 -0.485294118 0 serum_phospholipids serum_phospholipids 0.0992 0.00716 no no no up up no d18:1-20:1-SM+blood 18:0/20:4-PC+blood 0 0.595588235 0 serum_phospholipids serum_phospholipids 0.0992 0.454 no no no no no no d18:1-20:1-SM+blood 18:0/20:5-PC+blood 0 0.644607843 0 serum_phospholipids serum_phospholipids 0.0992 0.17 no no no no no no d18:1-20:1-SM+blood 18:1-LPC+blood 0 0.566176471 0 serum_phospholipids serum_phospholipids 0.0992 0.179 no no no no no no d18:1-20:1-SM+blood 18:1/16:1-PE+blood 0 -0.519607843 0 serum_phospholipids serum_phospholipids 0.0992 0.000184 no no no up up no d18:1-20:1-SM+blood 18:1/18:0-PE+blood 0 -0.490196078 0 serum_phospholipids serum_phospholipids 0.0992 1.39E-06 no no no up up no d18:1-20:1-SM+blood 18:1/18:0-PS+blood 0.560902256 0 0 serum_phospholipids serum_phospholipids 0.0992 0.193 no no no no no no d18:1-20:1-SM+blood 18:1/18:1-PC+blood 0 -0.585784314 0 serum_phospholipids serum_phospholipids 0.0992 1.34E-05 no no no no up up d18:1-20:1-SM+blood 18:1/18:1-PE+blood 0 -0.487745098 0 serum_phospholipids serum_phospholipids 0.0992 1.03E-05 no no no up up no d18:1-20:1-SM+blood 18:1/18:1-PG+blood 0 -0.551470588 0 serum_phospholipids serum_phospholipids 0.0992 0.00352 no no no no up up d18:1-20:1-SM+blood 18:1/18:2-PG+blood 0.490225564 0 0.506324786 serum_phospholipids serum_phospholipids 0.0992 5.58E-07 no no no no up up d18:1-20:1-SM+blood 18:1/20:4-PC+blood 0 0.676470588 0 serum_phospholipids serum_phospholipids 0.0992 0.582 no no no no no no d18:1-20:1-SM+blood 18:2/18:2-PS+blood 0 -0.531862745 0 serum_phospholipids serum_phospholipids 0.0992 0.00674 no no no up up no d18:1-20:1-SM+blood 20:0/20:5-PC+blood 0 0.534313725 0 serum_phospholipids serum_phospholipids 0.0992 0.882 no no no no no no d18:1-20:1-SM+blood 20:1-LPC+blood 0 0.509803922 0 serum_phospholipids serum_phospholipids 0.0992 0.217 no no no no no no d18:1-20:1-SM+blood 20:1/20:4-PE+blood 0.514285714 0 0 serum_phospholipids serum_phospholipids 0.0992 0.0042 no no no up up no d18:1-20:1-SM+blood 20:1+blood 0.491729323 0 0 yes serum_phospholipids serum_fattyacid 0.0992 2.56E-05 no no no dn dn dn d18:1-20:1-SM+blood 20:3n6+blood 0 -0.612745098 0 serum_phospholipids serum_fattyacid 0.0992 0.0884 no no no up no no d18:1-20:1-SM+blood 20:4-LPC+blood 0 0.590686275 0.575384615 serum_phospholipids serum_phospholipids 0.0992 0.949 no no no no no no d18:1-20:1-SM+blood 20:4-LPE+blood 0 0 0.535042735 serum_phospholipids serum_phospholipids 0.0992 0.552 no no no no no no d18:1-20:1-SM+blood 8-HETE+blood 0.538345865 0 0 serum_phospholipids serum_ARA 0.0992 0.741 no no no no no no d18:1-20:1-SM+blood AA+blood 0.556390977 0 0 serum_phospholipids serum_ARA 0.0992 0.212 no no no no no no d18:1-20:1-SM+blood acetic acid C2+blood 0 0.558823529 0 serum_phospholipids serum_scfa 0.0992 0.000193 no no no up dn no d18:1-20:1-SM+blood Antigen processing and presentation 0.49122807 0 0 serum_phospholipids kegg 0.0992 NA no no no no no no d18:1-20:1-SM+blood d18:0-16:0-SM+blood 0.612030075 0.642156863 0 serum_phospholipids serum_phospholipids 0.0992 0.202 no no no no no no d18:1-20:1-SM+blood d18:0-18:3-SM+blood 0.604511278 0.566176471 0.52957265 serum_phospholipids serum_phospholipids 0.0992 0.0879 no no no no dn no d18:1-20:1-SM+blood d18:1-16:0-SM+blood 0.621052632 0.656862745 0 serum_phospholipids serum_phospholipids 0.0992 0.14 no no no no no no d18:1-20:1-SM+blood d18:1-18:0-SM+blood 0.72481203 0.767156863 0.556239316 serum_phospholipids serum_phospholipids 0.0992 0.97 no no no no no no d18:1-20:1-SM+blood d18:1-18:1-SM+blood 0.819548872 0.794117647 0.644444444 serum_phospholipids serum_phospholipids 0.0992 0.916 no no no no no no d18:1-20:1-SM+blood d18:1-20:0-SM+blood 0.621052632 0.757352941 0 serum_phospholipids serum_phospholipids 0.0992 0.933 no no no no no no d18:1-20:1-SM+blood Epstein-Barr virus infection 0 -0.558823529 0 serum_phospholipids kegg 0.0992 NA no no no no no no d18:1-20:1-SM+blood GCDCA+stool 0 -0.7 0 yes serum_phospholipids stool_bileacids 0.0992 0.0471 no no no no dn no d18:1-20:1-SM+blood Herpes simplex virus 1 infection 0 -0.567647059 0 serum_phospholipids kegg 0.0992 NA no no no no no no d18:1-20:1-SM+blood Human T-cell leukemia virus 1 infection 0.478947368 -0.544117647 0 serum_phospholipids kegg 0.0992 NA no no no no no no d18:1-20:1-SM+blood Intestinal immune network for IgA production 0 -0.505882353 0 serum_phospholipids kegg 0.0992 NA no no no no no no d18:1-20:1-SM+blood Mineral absorption -0.498245614 0 0 serum_phospholipids kegg 0.0992 NA no no no no no no d18:1-20:1-SM+blood mTOR signaling pathway -0.505263158 0 0 serum_phospholipids kegg 0.0992 NA no no no no no no d18:1-20:1-SM+blood Phenylacetic acid+stool 0.725274725 0.790909091 0 serum_phospholipids stool_cometabolism 0.0992 0.785 no no no no no no d18:1-20:1-SM+blood Propionic acid+stool 0 0.663636364 0 yes serum_phospholipids stool_scfa 0.0992 0.0436 no no no dn no up d18:1-20:1-SM+blood TCA+stool 0 -0.7 0 serum_phospholipids stool_bileacids 0.0992 0.458 no no no no no no d18:1-20:1-SM+blood Th17 cell differentiation 0 0 -0.425384615 serum_phospholipids kegg 0.0992 NA no no no no no no d18:1-20:1-SM+blood total_stool_scfa+stool 0 0.772727273 0 serum_phospholipids stool_scfa 0.0992 0.0534 no no no dn no up d18:1-20:1-SM+blood Yersinia infection 0.487719298 0 0 serum_phospholipids kegg 0.0992 NA no no no no no no d18:1-22:0-SM+blood 12-ketoDCA+blood 0 0.487390898 0 serum_phospholipids serum_bileacids 0.522 0.517 no no no no no no d18:1-22:0-SM+blood "12,13-EPOME+blood" 0.454050311 0 0 serum_phospholipids serum_ARA 0.522 0.901 no no no no no no d18:1-22:0-SM+blood 14:0/20:4-PC+blood 0 0 0.421538462 serum_phospholipids serum_phospholipids 0.522 0.486 no no no no no no d18:1-22:0-SM+blood 14:0+blood 0 -0.485294118 0 yes serum_phospholipids serum_fattyacid 0.522 0.00572 no no no up no dn d18:1-22:0-SM+blood 16:0/18:2-PC+blood 0 0 -0.465982906 serum_phospholipids serum_phospholipids 0.522 3.24E-06 no no no no up up d18:1-22:0-SM+blood 16:0/22:6-PE+blood 0 0 -0.419487179 serum_phospholipids serum_phospholipids 0.522 0.000934 no no no up up no d18:1-22:0-SM+blood 16:1/16:0-PC+blood 0 0 -0.611623932 serum_phospholipids serum_phospholipids 0.522 0.0215 no no no no up up d18:1-22:0-SM+blood 16:1/16:1-PC+blood 0 0 -0.673846154 serum_phospholipids serum_phospholipids 0.522 0.0177 no no no no no up d18:1-22:0-SM+blood 18:0/18:0-PC+blood 0 0.549019608 0.476923077 serum_phospholipids serum_phospholipids 0.522 0.426 no no no no no no d18:1-22:0-SM+blood 18:0/18:1-PC+blood 0 0.529411765 0.503589744 serum_phospholipids serum_phospholipids 0.522 0.393 no no no no no no d18:1-22:0-SM+blood 18:0/20:2-PC+blood 0 0.774509804 0.742222222 serum_phospholipids serum_phospholipids 0.522 0.733 no no no no no no d18:1-22:0-SM+blood 18:1-LPC+blood 0 0 0.445470085 serum_phospholipids serum_phospholipids 0.522 0.179 no no no no no no d18:1-22:0-SM+blood 18:1/16:0-PC+blood 0 0 -0.45025641 serum_phospholipids serum_phospholipids 0.522 2.43E-05 no no no no up up d18:1-22:0-SM+blood 18:1/18:1-PI+blood 0 0 0.455726496 serum_phospholipids serum_phospholipids 0.522 0.111 no no no dn no no d18:1-22:0-SM+blood 18:1/18:2-PI+blood 0 -0.485294118 0 serum_phospholipids serum_phospholipids 0.522 0.0164 no no no dn no up d18:1-22:0-SM+blood 18:1+blood 0 -0.602941176 0 yes serum_phospholipids serum_fattyacid 0.522 0.00202 no no no up no dn d18:1-22:0-SM+blood 20:0-LPC+blood 0 0.485294118 0.718290598 serum_phospholipids serum_phospholipids 0.522 0.199 no no no no no no d18:1-22:0-SM+blood 20:0-LPE+blood 0.466165414 0 0 serum_phospholipids serum_phospholipids 0.522 0.0615 no no no no no up d18:1-22:0-SM+blood 20:0/20:5-PC+blood 0 0.625 0 serum_phospholipids serum_phospholipids 0.522 0.882 no no no no no no d18:1-22:0-SM+blood 20:1-LPC+blood 0 0 0.401709402 serum_phospholipids serum_phospholipids 0.522 0.217 no no no no no no d18:1-22:0-SM+blood 20:1+blood 0 0 0.402393162 yes serum_phospholipids serum_fattyacid 0.522 2.56E-05 no no no dn dn dn d18:1-22:0-SM+blood 24:1+blood -0.497744361 0 0 serum_phospholipids serum_fattyacid 0.522 0.00582 no no no no dn dn d18:1-22:0-SM+blood "9,10-EPOME+blood" 0.490128712 0 0 serum_phospholipids serum_ARA 0.522 0.801 no no no no no no d18:1-22:0-SM+blood Butyric acid+stool -0.653846154 0 0 yes serum_phospholipids stool_scfa 0.522 0.102 no no no dn no no d18:1-22:0-SM+blood Butyricicoccus 0.490524166 0 0 butyrate-producing serum_phospholipids Genus 0.522 0.852 no no no no no no d18:1-22:0-SM+blood Clostridium 0 0 -0.530742499 serum_phospholipids Genus 0.522 0.925 no no no no no no d18:1-22:0-SM+blood Cytosolic DNA-sensing pathway 0.578947368 0 0 serum_phospholipids kegg 0.522 NA no no no no no no d18:1-22:0-SM+blood d18:0-16:0-SM+blood 0.684210526 0 0.475555556 serum_phospholipids serum_phospholipids 0.522 0.202 no no no no no no d18:1-22:0-SM+blood d18:0-18:3-SM+blood 0.463157895 0 0 serum_phospholipids serum_phospholipids 0.522 0.0879 no no no no dn no d18:1-22:0-SM+blood d18:0-24:1-SM+blood 0.598496241 0.857843137 0.714871795 serum_phospholipids serum_phospholipids 0.522 0.0609 no no no no dn dn d18:1-22:0-SM+blood d18:1-14:0-SM+blood 0 0.526960784 0.508376068 serum_phospholipids serum_phospholipids 0.522 0.94 no no no no no no d18:1-22:0-SM+blood d18:1-14:1-SM+blood 0 0.583333333 0 serum_phospholipids serum_phospholipids 0.522 0.0952 no no no no dn no d18:1-22:0-SM+blood d18:1-16:0-SM+blood 0.688721805 0 0.459145299 serum_phospholipids serum_phospholipids 0.522 0.14 no no no no no no d18:1-22:0-SM+blood d18:1-16:1-SM+blood 0.512781955 0.487745098 0.422222222 serum_phospholipids serum_phospholipids 0.522 0.2 no no no no no no d18:1-22:0-SM+blood d18:1-20:0-SM+blood 0.520300752 0.605392157 0.588376068 serum_phospholipids serum_phospholipids 0.522 0.933 no no no no no no d18:1-22:0-SM+blood Faecalibacterium 0 0 0.439391355 butyrate-producing serum_phospholipids Genus 0.522 0.0039 no no no no dn dn d18:1-22:0-SM+blood GABAergic synapse 0 0 -0.427692308 serum_phospholipids kegg 0.522 NA no no no no up up d18:1-22:0-SM+blood Gastric cancer -0.461403509 0 0 serum_phospholipids kegg 0.522 NA no no no no no no d18:1-22:0-SM+blood Glutamatergic synapse -0.471929825 0 0 serum_phospholipids kegg 0.522 NA no no no no up up d18:1-22:0-SM+blood Hematopoietic cell lineage -0.485964912 0 0 serum_phospholipids kegg 0.522 NA no no no no no no d18:1-22:0-SM+blood Herpes simplex virus 1 infection 0.477192982 0 0 serum_phospholipids kegg 0.522 NA no no no no no no d18:1-22:0-SM+blood Human cytomegalovirus infection 0 0 -0.401538462 serum_phospholipids kegg 0.522 NA no no no no no dn d18:1-22:0-SM+blood Human T-cell leukemia virus 1 infection 0.48245614 0 0 serum_phospholipids kegg 0.522 NA no no no no no no d18:1-22:0-SM+blood IL-17 signaling pathway 0 0 -0.471538462 serum_phospholipids kegg 0.522 NA no no no no no no d18:1-22:0-SM+blood Measles 0.592982456 0 0 serum_phospholipids kegg 0.522 NA no no no no no no d18:1-22:0-SM+blood Parabacteroides 0 0.580882353 0 serum_phospholipids Genus 0.522 4.19E-05 no no no no up up d18:1-22:0-SM+blood Paraprevotella 0 0 0.420819241 serum_phospholipids Genus 0.522 0.118 no no no no no no d18:1-22:1-SM+blood 11-HETE+blood 0 -0.567841301 0 serum_phospholipids serum_ARA 0.222 0.464 no no no no no no d18:1-22:1-SM+blood 12-HEPE+blood 0 0 -0.45261668 serum_phospholipids serum_ARA 0.222 0.312 no no no no no no d18:1-22:1-SM+blood 12-ketoDCA+blood 0 0.490684079 0 serum_phospholipids serum_bileacids 0.222 0.517 no no no no no no d18:1-22:1-SM+blood "12,13-EPOME+blood" 0 -0.643861597 0 serum_phospholipids serum_ARA 0.222 0.901 no no no no no no d18:1-22:1-SM+blood 14:0/20:4-PC+blood 0 0 0.632136752 serum_phospholipids serum_phospholipids 0.222 0.486 no no no no no no d18:1-22:1-SM+blood 14:1/18:2-PG+blood 0 0 0.42017094 serum_phospholipids serum_phospholipids 0.222 0.00259 no no no no up up d18:1-22:1-SM+blood 16:0/14:0-PC+blood 0 -0.5 0 serum_phospholipids serum_phospholipids 0.222 0.0206 no no no no up up d18:1-22:1-SM+blood 16:0/18:2-PC+blood 0 -0.590686275 -0.602051282 serum_phospholipids serum_phospholipids 0.222 3.24E-06 no no no no up up d18:1-22:1-SM+blood 16:0/22:6-PC+blood 0 0 -0.42974359 serum_phospholipids serum_phospholipids 0.222 4.53E-05 no no no no up up d18:1-22:1-SM+blood 16:1/16:0-PC+blood 0 0 -0.653333333 serum_phospholipids serum_phospholipids 0.222 0.0215 no no no no up up d18:1-22:1-SM+blood 16:1/16:1-PC+blood 0 0 -0.496068376 serum_phospholipids serum_phospholipids 0.222 0.0177 no no no no no up d18:1-22:1-SM+blood 18:0-LPC+blood 0 0.573529412 0.498119658 serum_phospholipids serum_phospholipids 0.222 0.554 no no no no no no d18:1-22:1-SM+blood 18:0/18:0-PC+blood 0 0 0.403076923 serum_phospholipids serum_phospholipids 0.222 0.426 no no no no no no d18:1-22:1-SM+blood 18:0/18:1-PC+blood 0 0 0.414700855 serum_phospholipids serum_phospholipids 0.222 0.393 no no no no no no d18:1-22:1-SM+blood 18:0/18:2-PC+blood 0 -0.549019608 0 serum_phospholipids serum_phospholipids 0.222 1.74E-06 no no no no up up d18:1-22:1-SM+blood 18:0/20:2-PC+blood 0 0 0.571282051 serum_phospholipids serum_phospholipids 0.222 0.733 no no no no no no d18:1-22:1-SM+blood 18:0/20:3-PC+blood 0 0 0.404444444 serum_phospholipids serum_phospholipids 0.222 0.0682 no no no no up no d18:1-22:1-SM+blood 18:1/16:0-PC+blood 0 -0.541666667 -0.58974359 serum_phospholipids serum_phospholipids 0.222 2.43E-05 no no no no up up d18:1-22:1-SM+blood 18:1/18:0-PC+blood 0 -0.534313725 0 serum_phospholipids serum_phospholipids 0.222 1.83E-06 no no no no up up d18:1-22:1-SM+blood 18:1/18:1-PI+blood 0 0 0.418803419 serum_phospholipids serum_phospholipids 0.222 0.111 no no no dn no no d18:1-22:1-SM+blood 18:1/20:4-PE+blood 0.488721805 0 0 serum_phospholipids serum_phospholipids 0.222 0.0578 no no no up no no d18:1-22:1-SM+blood 18:1/22:6-PE+blood 0.476691729 0 0 serum_phospholipids serum_phospholipids 0.222 0.0047 no no no no up no d18:1-22:1-SM+blood 18:2n6c+blood 0 -0.504901961 0 serum_phospholipids serum_fattyacid 0.222 0.15 no no no no no no d18:1-22:1-SM+blood 20:0-LPC+blood 0 0.715686275 0.642393162 serum_phospholipids serum_phospholipids 0.222 0.199 no no no no no no d18:1-22:1-SM+blood 20:0/20:4-PE+blood 0 0 0.438632479 serum_phospholipids serum_phospholipids 0.222 0.00128 no no no up up no d18:1-22:1-SM+blood 20:0/20:5-PC+blood 0 0.49754902 0 serum_phospholipids serum_phospholipids 0.222 0.882 no no no no no no d18:1-22:1-SM+blood 20:1-LPC+blood 0.479699248 0.5 0 serum_phospholipids serum_phospholipids 0.222 0.217 no no no no no no d18:1-22:1-SM+blood 20:1-LPE+blood 0 0.529411765 0 serum_phospholipids serum_phospholipids 0.222 0.465 no no no no no no d18:1-22:1-SM+blood 20:1/20:4-PE+blood 0.622556391 0 0 serum_phospholipids serum_phospholipids 0.222 0.0042 no no no up up no d18:1-22:1-SM+blood 20:1+blood 0.542857143 0 0 yes serum_phospholipids serum_fattyacid 0.222 2.56E-05 no no no dn dn dn d18:1-22:1-SM+blood 20:2/18:3-PE+blood 0.49924812 0 0 serum_phospholipids serum_phospholipids 0.222 0.0391 no no no up up no d18:1-22:1-SM+blood 20:3-LPC+blood 0 0 0.440683761 serum_phospholipids serum_phospholipids 0.222 0.0292 no no no no up no d18:1-22:1-SM+blood 20:4-LPC+blood 0 0 0.409230769 serum_phospholipids serum_phospholipids 0.222 0.949 no no no no no no d18:1-22:1-SM+blood 20:4n6+blood 0.467669173 0 0 serum_phospholipids serum_fattyacid 0.222 0.133 no no no no no no d18:1-22:1-SM+blood acetic acid C2+blood 0 0.529411765 0 serum_phospholipids serum_scfa 0.222 0.000193 no no no up dn no d18:1-22:1-SM+blood Akkermansia 0.482820486 0 0 acetate-producing serum_phospholipids Genus 0.222 0.23 no no no no no no d18:1-22:1-SM+blood Alistipes 0 0.508890347 0 serum_phospholipids Genus 0.222 0.0114 no no no no up no d18:1-22:1-SM+blood AMPK signaling pathway -0.529824561 0 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Antigen processing and presentation 0.575438596 -0.561764706 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Butyric acid+stool -0.571428571 0 0 yes serum_phospholipids stool_scfa 0.222 0.102 no no no dn no no d18:1-22:1-SM+blood Calcium signaling pathway 0 0.502941176 0 serum_phospholipids kegg 0.222 NA no no no no up up d18:1-22:1-SM+blood Chemical carcinogenesis - receptor activation 0 0.635294118 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Collinsella 0 -0.537618109 0 serum_phospholipids Genus 0.222 0.128 no no no no no no d18:1-22:1-SM+blood Creatinine+blood 0 0 -0.488547009 serum_phospholipids serum_choline 0.222 0.437 no no no no no no d18:1-22:1-SM+blood Cushing syndrome 0 0.520588235 0 serum_phospholipids kegg 0.222 NA no no no no no up d18:1-22:1-SM+blood d18:0-16:0-SM+blood 0.852631579 0.803921569 0.728547009 serum_phospholipids serum_phospholipids 0.222 0.202 no no no no no no d18:1-22:1-SM+blood d18:0-18:3-SM+blood 0.751879699 0.512254902 0.586324786 serum_phospholipids serum_phospholipids 0.222 0.0879 no no no no dn no d18:1-22:1-SM+blood d18:0-24:1-SM+blood 0.654135338 0.580882353 0.56991453 serum_phospholipids serum_phospholipids 0.222 0.0609 no no no no dn dn d18:1-22:1-SM+blood d18:1-14:0-SM+blood 0 0.517156863 0.61982906 serum_phospholipids serum_phospholipids 0.222 0.94 no no no no no no d18:1-22:1-SM+blood d18:1-14:1-SM+blood 0 0.644607843 0.602051282 serum_phospholipids serum_phospholipids 0.222 0.0952 no no no no dn no d18:1-22:1-SM+blood d18:1-16:0-SM+blood 0.857142857 0.786764706 0.71965812 serum_phospholipids serum_phospholipids 0.222 0.14 no no no no no no d18:1-22:1-SM+blood d18:1-16:1-SM+blood 0.836090226 0.806372549 0.734700855 serum_phospholipids serum_phospholipids 0.222 0.2 no no no no no no d18:1-22:1-SM+blood d18:1-18:1-SM+blood 0.556390977 0.49754902 0 serum_phospholipids serum_phospholipids 0.222 0.916 no no no no no no d18:1-22:1-SM+blood d18:1-20:0-SM+blood 0.781954887 0.87254902 0.74017094 serum_phospholipids serum_phospholipids 0.222 0.933 no no no no no no d18:1-22:1-SM+blood d18:1-20:1-SM+blood 0.627067669 0.705882353 0 serum_phospholipids serum_phospholipids 0.222 0.0992 no no no no no no d18:1-22:1-SM+blood d18:1-22:0-SM+blood 0.637593985 0.583333333 0.762735043 serum_phospholipids serum_phospholipids 0.222 0.522 no no no no no no d18:1-22:1-SM+blood Endocrine resistance 0 0.614705882 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Epstein-Barr virus infection 0.464912281 -0.55 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Gap junction 0 0 0.443846154 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Gastric cancer -0.60877193 0.526470588 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood GDCA+stool 0.71978022 0 0 serum_phospholipids stool_bileacids 0.222 0.656 no no no no no no d18:1-22:1-SM+blood Glutathione metabolism 0 0 0.405384615 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood GnRH signaling pathway 0 0.514705882 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Herpes simplex virus 1 infection 0.494736842 -0.591176471 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood HIF-1 signaling pathway -0.521052632 0 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Human cytomegalovirus infection 0.489473684 0 0 serum_phospholipids kegg 0.222 NA no no no no no dn d18:1-22:1-SM+blood Human immunodeficiency virus 1 infection 0.459649123 -0.511764706 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Human T-cell leukemia virus 1 infection 0.585964912 -0.561764706 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Insulin signaling pathway -0.501754386 0 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Long-term depression 0 0 0.437692308 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Longevity regulating pathway -0.507017544 0 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Mineral absorption -0.542105263 0 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Mitophagy - animal -0.510526316 0 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood mTOR signaling pathway -0.480701754 0 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Necroptosis -0.480701754 0 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Neuroactive ligand-receptor interaction 0 0 -0.425384615 serum_phospholipids kegg 0.222 NA no no no up up up d18:1-22:1-SM+blood Pathogenic Escherichia coli infection 0.477192982 0 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Phenylacetic acid+stool 0 0.609090909 0 serum_phospholipids stool_cometabolism 0.222 0.785 no no no no no no d18:1-22:1-SM+blood Propionic acid+stool -0.653846154 0 0 yes serum_phospholipids stool_scfa 0.222 0.0436 no no no dn no up d18:1-22:1-SM+blood Proteasome 0 0 -0.463076923 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Ruminococcus 0 -0.570202437 0 serum_phospholipids Genus 0.222 0.0679 no no no no no dn d18:1-22:1-SM+blood Signaling pathways regulating pluripotency of stem cells 0 0.561764706 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood Thyroid hormone synthesis 0 0 0.533846154 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-22:1-SM+blood total_stool_scfa+stool -0.692307692 0 0 serum_phospholipids stool_scfa 0.222 0.0534 no no no dn no up d18:1-22:1-SM+blood Ubiquitin mediated proteolysis -0.477192982 0 0 serum_phospholipids kegg 0.222 NA no no no no no no d18:1-24:1-SM+blood 12-ketoDCA+blood 0 0.559840896 0 serum_phospholipids serum_bileacids 0.0123 0.517 no dn dn no no no d18:1-24:1-SM+blood "12,13-EPOME+blood" 0 -0.586239742 0 serum_phospholipids serum_ARA 0.0123 0.901 no dn dn no no no d18:1-24:1-SM+blood 14:0+blood 0 -0.573529412 0 yes serum_phospholipids serum_fattyacid 0.0123 0.00572 no dn dn up no dn d18:1-24:1-SM+blood 16:0/18:2-PC+blood 0 0 -0.435897436 serum_phospholipids serum_phospholipids 0.0123 3.24E-06 no dn dn no up up d18:1-24:1-SM+blood 16:0/20:5-PG+blood 0.520300752 0 0 serum_phospholipids serum_phospholipids 0.0123 0.00656 no dn dn no up no d18:1-24:1-SM+blood 16:1/16:0-PC+blood 0 0 -0.469401709 serum_phospholipids serum_phospholipids 0.0123 0.0215 no dn dn no up up d18:1-24:1-SM+blood 16:1/16:1-PC+blood 0 0 -0.522735043 serum_phospholipids serum_phospholipids 0.0123 0.0177 no dn dn no no up d18:1-24:1-SM+blood 18:0/18:0-PE+blood 0 -0.62254902 0 serum_phospholipids serum_phospholipids 0.0123 0.00896 no dn dn up up no d18:1-24:1-SM+blood 18:0/18:1-PC+blood 0 0 0.405128205 serum_phospholipids serum_phospholipids 0.0123 0.393 no dn dn no no no d18:1-24:1-SM+blood 18:0/18:1-PE+blood 0 -0.526960784 0 serum_phospholipids serum_phospholipids 0.0123 0.00716 no dn dn up up no d18:1-24:1-SM+blood 18:0/20:2-PC+blood 0 0.549019608 0.645811966 serum_phospholipids serum_phospholipids 0.0123 0.733 no dn dn no no no d18:1-24:1-SM+blood 18:1-LPC+blood 0 0 0.433162393 serum_phospholipids serum_phospholipids 0.0123 0.179 no dn dn no no no d18:1-24:1-SM+blood 18:1/16:0-PC+blood 0 0 -0.414017094 serum_phospholipids serum_phospholipids 0.0123 2.43E-05 no dn dn no up up d18:1-24:1-SM+blood 18:1/16:0-PE+blood 0 -0.558823529 0 serum_phospholipids serum_phospholipids 0.0123 0.000182 no dn dn up up no d18:1-24:1-SM+blood 18:1/18:0-PE+blood 0 -0.56127451 0 serum_phospholipids serum_phospholipids 0.0123 1.39E-06 no dn dn up up no d18:1-24:1-SM+blood 18:1/18:1-PE+blood 0 -0.531862745 0 serum_phospholipids serum_phospholipids 0.0123 1.03E-05 no dn dn up up no d18:1-24:1-SM+blood 18:1/18:2-PE+blood 0 -0.49754902 0 serum_phospholipids serum_phospholipids 0.0123 0.000293 no dn dn up up no d18:1-24:1-SM+blood 18:1/20:4-PC+blood 0.445112782 0.539215686 0 serum_phospholipids serum_phospholipids 0.0123 0.582 no dn dn no no no d18:1-24:1-SM+blood 18:2-LPE+blood -0.47518797 0 0 serum_phospholipids serum_phospholipids 0.0123 0.112 no dn dn no no no d18:1-24:1-SM+blood 18:2n6c+blood 0 -0.549019608 0 serum_phospholipids serum_fattyacid 0.0123 0.15 no dn dn no no no d18:1-24:1-SM+blood 20:0-LPC+blood 0 0.490196078 0.446153846 serum_phospholipids serum_phospholipids 0.0123 0.199 no dn dn no no no d18:1-24:1-SM+blood 20:0/20:5-PC+blood 0 0.693627451 0 serum_phospholipids serum_phospholipids 0.0123 0.882 no dn dn no no no d18:1-24:1-SM+blood 20:3/18:0-PC+blood 0 0.485294118 0 serum_phospholipids serum_phospholipids 0.0123 0.296 no dn dn no no no d18:1-24:1-SM+blood 20:4n6+blood 0.538345865 0 0 serum_phospholipids serum_fattyacid 0.0123 0.133 no dn dn no no no d18:1-24:1-SM+blood "9,10-EPOME+blood" 0.450180917 0 0 serum_phospholipids serum_ARA 0.0123 0.801 no dn dn no no no d18:1-24:1-SM+blood Antigen processing and presentation 0 -0.55 0 serum_phospholipids kegg 0.0123 NA no dn dn no no no d18:1-24:1-SM+blood Arginine and proline metabolism 0.592982456 0 0 serum_phospholipids kegg 0.0123 NA no dn dn no up no d18:1-24:1-SM+blood Asthma 0 0 0.411538462 serum_phospholipids kegg 0.0123 NA no dn dn no no no d18:1-24:1-SM+blood Butyricimonas 0 0 -0.401833329 butyrate-producing serum_phospholipids Genus 0.0123 0.17 no dn dn no no no d18:1-24:1-SM+blood Clostridium -0.594960554 0 0.410637065 serum_phospholipids Genus 0.0123 0.925 no dn dn no no no d18:1-24:1-SM+blood Clostridium -0.594960554 0 -0.433603952 serum_phospholipids Genus 0.0123 0.925 no dn dn no no no d18:1-24:1-SM+blood Coprococcus 0.44962406 0 0 butyrate-producing serum_phospholipids Genus 0.0123 0.612 no dn dn no no no d18:1-24:1-SM+blood d18:0-16:0-SM+blood 0.509774436 0.585784314 0.476239316 serum_phospholipids serum_phospholipids 0.0123 0.202 no dn dn no no no d18:1-24:1-SM+blood d18:0-24:1-SM+blood 0.587969925 0.818627451 0.72034188 serum_phospholipids serum_phospholipids 0.0123 0.0609 no dn dn no dn dn d18:1-24:1-SM+blood d18:1-14:0-SM+blood 0 0 0.48034188 serum_phospholipids serum_phospholipids 0.0123 0.94 no dn dn no no no d18:1-24:1-SM+blood d18:1-14:1-SM+blood 0 0.495098039 0 serum_phospholipids serum_phospholipids 0.0123 0.0952 no dn dn no dn no d18:1-24:1-SM+blood d18:1-16:0-SM+blood 0.527819549 0.578431373 0.475555556 serum_phospholipids serum_phospholipids 0.0123 0.14 no dn dn no no no d18:1-24:1-SM+blood d18:1-16:1-SM+blood 0 0.571078431 0.461880342 serum_phospholipids serum_phospholipids 0.0123 0.2 no dn dn no no no d18:1-24:1-SM+blood d18:1-20:0-SM+blood 0 0.737745098 0 serum_phospholipids serum_phospholipids 0.0123 0.933 no dn dn no no no d18:1-24:1-SM+blood d18:1-20:1-SM+blood 0 0.580882353 0 serum_phospholipids serum_phospholipids 0.0123 0.0992 no dn dn no no no d18:1-24:1-SM+blood d18:1-22:0-SM+blood 0.681203008 0.899509804 0.87965812 serum_phospholipids serum_phospholipids 0.0123 0.522 no dn dn no no no d18:1-24:1-SM+blood d18:1-22:1-SM+blood 0 0.705882353 0.66974359 serum_phospholipids serum_phospholipids 0.0123 0.222 no dn dn no no no d18:1-24:1-SM+blood Epstein-Barr virus infection 0 -0.579411765 0 serum_phospholipids kegg 0.0123 NA no dn dn no no no d18:1-24:1-SM+blood Faecalibacterium 0 0 0.487604726 butyrate-producing serum_phospholipids Genus 0.0123 0.0039 no dn dn no dn dn d18:1-24:1-SM+blood GABAergic synapse 0 0 -0.416923077 serum_phospholipids kegg 0.0123 NA no dn dn no up up d18:1-24:1-SM+blood Hematopoietic cell lineage 0 0 0.447692308 serum_phospholipids kegg 0.0123 NA no dn dn no no no d18:1-24:1-SM+blood Herpes simplex virus 1 infection 0 -0.582352941 0 serum_phospholipids kegg 0.0123 NA no dn dn no no no d18:1-24:1-SM+blood Human cytomegalovirus infection 0 -0.535294118 0 serum_phospholipids kegg 0.0123 NA no dn dn no no dn d18:1-24:1-SM+blood Human immunodeficiency virus 1 infection 0 -0.555882353 0 serum_phospholipids kegg 0.0123 NA no dn dn no no no d18:1-24:1-SM+blood Human T-cell leukemia virus 1 infection 0 -0.591176471 0 serum_phospholipids kegg 0.0123 NA no dn dn no no no d18:1-24:1-SM+blood Inflammatory bowel disease 0 0 0.443076923 serum_phospholipids kegg 0.0123 NA no dn dn no no no d18:1-24:1-SM+blood Inflammatory mediator regulation of TRP channels -0.463157895 0 0 serum_phospholipids kegg 0.0123 NA no dn dn no no no d18:1-24:1-SM+blood Intestinal immune network for IgA production 0 0 0.439230769 serum_phospholipids kegg 0.0123 NA no dn dn no no no d18:1-24:1-SM+blood JAK-STAT signaling pathway 0.468421053 0 0 serum_phospholipids kegg 0.0123 NA no dn dn no no no d18:1-24:1-SM+blood Measles 0.538596491 0 0 serum_phospholipids kegg 0.0123 NA no dn dn no no no d18:1-24:1-SM+blood TCA+stool 0 -0.672727273 0 serum_phospholipids stool_bileacids 0.0123 0.458 no dn dn no no no d18:1-24:1-SM+blood TDCA+stool 0 -0.776954316 0 serum_phospholipids stool_bileacids 0.0123 0.963 no dn dn no no no DCA+blood 12-HEPE+blood 0.445082418 0 0 serum_bileacids serum_ARA 0.122 0.312 no no no no no no DCA+blood 12-ketoDCA+blood 0.619498108 0.602652259 0 serum_bileacids serum_bileacids 0.122 0.517 no no no no no no DCA+blood "12,13-EPOME+blood" 0 0 0.511601235 serum_bileacids serum_ARA 0.122 0.901 no no no no no no DCA+blood 16:0/16:1-PI+blood 0.466165414 0 0 serum_bileacids serum_phospholipids 0.122 0.262 no no no no no no DCA+blood 16:0/18:0-PC+blood -0.479699248 0 0 serum_bileacids serum_phospholipids 0.122 0.521 no no no no no no DCA+blood 16:0/18:0-PS+blood -0.460150376 -0.549019608 0 serum_bileacids serum_phospholipids 0.122 0.377 no no no no no no DCA+blood 16:0/20:4-PE+blood 0 -0.588235294 0 serum_bileacids serum_phospholipids 0.122 0.00139 no no no up up no DCA+blood 16:0/22:6-PE+blood -0.49924812 0 0 serum_bileacids serum_phospholipids 0.122 0.000934 no no no up up no DCA+blood 16:0+blood -0.44962406 -0.551470588 0 yes serum_bileacids serum_fattyacid 0.122 0.00876 no no no up no no DCA+blood 16:1/16:1-PC+blood -0.458646617 0 0 serum_bileacids serum_phospholipids 0.122 0.0177 no no no no no up DCA+blood 18:0-LPA+blood -0.455639098 0 0 serum_bileacids serum_phospholipids 0.122 0.0725 no no no no dn no DCA+blood 18:0-LPC+blood 0 0.674019608 0 serum_bileacids serum_phospholipids 0.122 0.554 no no no no no no DCA+blood 18:0/18:0-PS+blood -0.523308271 0 0 serum_bileacids serum_phospholipids 0.122 0.00617 no no no no up no DCA+blood 18:0/20:4-PC+blood 0 0 -0.427692308 serum_bileacids serum_phospholipids 0.122 0.454 no no no no no no DCA+blood 18:1/16:0-PE+blood 0 -0.482843137 0 serum_bileacids serum_phospholipids 0.122 0.000182 no no no up up no DCA+blood 18:1/18:0-PS+blood -0.44962406 0 0 serum_bileacids serum_phospholipids 0.122 0.193 no no no no no no DCA+blood 18:1/20:3-PC+blood 0 0.580882353 -0.401709402 serum_bileacids serum_phospholipids 0.122 0.00872 no no no no up up DCA+blood 18:1/20:4-PC+blood 0 0 -0.443418803 serum_bileacids serum_phospholipids 0.122 0.582 no no no no no no DCA+blood 18:1/20:4-PE+blood -0.596992481 -0.512254902 0 serum_bileacids serum_phospholipids 0.122 0.0578 no no no up no no DCA+blood 18:1/20:4-PI+blood 0 0 -0.422905983 serum_bileacids serum_phospholipids 0.122 0.192 no no no no no no DCA+blood 18:3-LPC+blood 0 0 0.406495726 serum_bileacids serum_phospholipids 0.122 0.147 no no no no no no DCA+blood 18:3n3+blood -0.515789474 0 0 serum_bileacids serum_fattyacid 0.122 0.291 no no no no no no DCA+blood 20:0-LPC+blood 0 0.656862745 0 serum_bileacids serum_phospholipids 0.122 0.199 no no no no no no DCA+blood 20:0/20:4-PE+blood -0.463157895 0 0 serum_bileacids serum_phospholipids 0.122 0.00128 no no no up up no DCA+blood 20:0/20:5-PC+blood 0 0 -0.40034188 serum_bileacids serum_phospholipids 0.122 0.882 no no no no no no DCA+blood 20:1/20:4-PE+blood -0.509774436 0 0 serum_bileacids serum_phospholipids 0.122 0.0042 no no no up up no DCA+blood 20:2-LPC+blood 0 0.495098039 0 serum_bileacids serum_phospholipids 0.122 0.119 no no no no no up DCA+blood 20:2/18:3-PE+blood -0.469172932 0 -0.504273504 serum_bileacids serum_phospholipids 0.122 0.0391 no no no up up no DCA+blood 20:3/18:0-PC+blood -0.511278195 0 0 serum_bileacids serum_phospholipids 0.122 0.296 no no no no no no DCA+blood 20:4-LPA+blood -0.664661654 0 -0.442735043 serum_bileacids serum_phospholipids 0.122 0.398 no no no no no no DCA+blood 20:4/18:0-PE+blood -0.62406015 0 0 serum_bileacids serum_phospholipids 0.122 0.000755 no no no up up no DCA+blood 20:5n3+blood 0 0 0.437264957 serum_bileacids serum_fattyacid 0.122 0.988 no no no no no no DCA+blood 9-HODE+blood 0 0 0.413333333 serum_bileacids serum_ARA 0.122 0.297 no no no no no no DCA+blood AA+blood -0.485714286 0 0 serum_bileacids serum_ARA 0.122 0.212 no no no no no no DCA+blood Adrenergic signaling in cardiomyocytes 0 0.514705882 0 serum_bileacids kegg 0.122 NA no no no no no up DCA+blood AGE-RAGE signaling pathway in diabetic complications 0 -0.517647059 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Alcoholism 0.471929825 0 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Aldosterone synthesis and secretion 0 0.644117647 0.413846154 serum_bileacids kegg 0.122 NA no no no no up up DCA+blood Alzheimer disease 0 0.532352941 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Apelin signaling pathway 0 0.520588235 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Bifidobacterium -0.448288862 0 0 acetate-producing serum_bileacids Genus 0.122 0.105 no no no no dn no DCA+blood Biosynthesis of amino acids 0 0 -0.513846154 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood butyric acid C4+blood -0.469172932 0 0 serum_bileacids serum_scfa 0.122 0.407 no no no no no no DCA+blood Butyric acid+stool 0 0.618181818 0 yes serum_bileacids stool_scfa 0.122 0.102 no no no dn no no DCA+blood CA+blood 0 0 0.621959063 serum_bileacids serum_bileacids 0.122 0.606 no no no no no no DCA+blood Calcium signaling pathway 0 0.776470588 0.430769231 serum_bileacids kegg 0.122 NA no no no no up up DCA+blood capric acid C6+blood 0 0 -0.414017094 serum_bileacids serum_scfa 0.122 0.433 no no no no no no DCA+blood Carbon metabolism 0 0 -0.557692308 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Cardiac muscle contraction 0 0.585294118 0 serum_bileacids kegg 0.122 NA no no no no no up DCA+blood CDCA+blood 0.52481203 0 0.681367521 serum_bileacids serum_bileacids 0.122 0.506 no no no no no no DCA+blood cGMP-PKG signaling pathway 0 0 -0.438461538 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Coronavirus disease - COVID-19 0 0.585294118 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Cushing syndrome 0 0 0.407692308 serum_bileacids kegg 0.122 NA no no no no no up DCA+blood Cystine+blood 0 0 -0.493333333 yes serum_bileacids serum_aminoacids 0.122 0.00028 no no no up up no DCA+blood d18:0-24:1-SM+blood 0 0.578431373 0 serum_bileacids serum_phospholipids 0.122 0.0609 no no no no dn dn DCA+blood d18:1-22:0-SM+blood 0 0.553921569 0 serum_bileacids serum_phospholipids 0.122 0.522 no no no no no no DCA+blood d18:1-22:1-SM+blood 0 0.509803922 0 serum_bileacids serum_phospholipids 0.122 0.222 no no no no no no DCA+blood d18:1-24:1-SM+blood 0 0.56372549 0 serum_bileacids serum_phospholipids 0.122 0.0123 no no no no dn dn DCA+blood Diabetic cardiomyopathy 0 0.55 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood EGFR tyrosine kinase inhibitor resistance 0 0.564705882 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Fc gamma R-mediated phagocytosis 0 0 -0.456153846 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood GABAergic synapse 0 0 -0.437692308 serum_bileacids kegg 0.122 NA no no no no up up DCA+blood Glucagon signaling pathway 0 0.558823529 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Glutathione metabolism 0.466666667 0 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Huntington disease 0 0.535294118 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Inflammatory mediator regulation of TRP channels 0 0.541176471 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Insulin signaling pathway 0 0.523529412 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood L-Phenylalanine+stool -0.664835165 0 0 serum_bileacids stool_cometabolism 0.122 0.398 no no no no no no DCA+blood L-Tryptophan+stool -0.71978022 0 0 serum_bileacids stool_cometabolism 0.122 0.557 no no no no no no DCA+blood L-Tyrosine+stool -0.664835165 0 0 serum_bileacids stool_cometabolism 0.122 0.44 no no no no no no DCA+blood Lysosome 0 0 -0.411538462 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Melanogenesis 0 0.65 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Mitophagy - animal 0.473684211 0.623529412 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Morphine addiction 0 0.505882353 0 serum_bileacids kegg 0.122 NA no no no no up up DCA+blood mTOR signaling pathway 0 0.555882353 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Neuroactive ligand-receptor interaction 0 -0.552941176 -0.406923077 serum_bileacids kegg 0.122 NA no no no up up up DCA+blood Neutrophil extracellular trap formation 0 -0.511764706 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Nicotinate and nicotinamide metabolism 0 -0.55 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Oxidative phosphorylation 0 0.535294118 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Pancreatic secretion 0 0.555882353 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood "Parathyroid hormone synthesis, secretion and action" 0 0.617647059 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Parkinson disease 0 0.514705882 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Pathways in cancer 0 0 0.429230769 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Pathways of neurodegeneration - multiple diseases 0 0.523529412 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Peroxisome 0 -0.508823529 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Pertussis 0 -0.511764706 0 serum_bileacids kegg 0.122 NA no no no no no dn DCA+blood PPAR signaling pathway 0 0 -0.546153846 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Purine metabolism 0 0.632352941 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Rheumatoid arthritis 0 -0.558823529 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Ribosome 0 0.585294118 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood RNA transport 0 0.570588235 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Shigellosis 0.538596491 0 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Slackia 0 0 0.49534449 serum_bileacids Genus 0.122 0.94 no no no no no no DCA+blood Staphylococcus aureus infection 0 -0.567647059 -0.479230769 serum_bileacids kegg 0.122 NA no no no up no no DCA+blood Systemic lupus erythematosus 0 -0.614705882 -0.48 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Thermogenesis 0 0.526470588 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Thyroid hormone synthesis 0 0.535294118 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+blood Tuberculosis 0 -0.626470588 -0.49 serum_bileacids kegg 0.122 NA no no no no no dn DCA+blood Ubiquitin mediated proteolysis 0 0.608823529 0 serum_bileacids kegg 0.122 NA no no no no no no DCA+stool 12-ketoDCA+stool 0.554179567 0.654992248 0.42687747 stool_bileacids stool_bileacids 0.195 0.505 no no no no no no DCA+stool 4-hydroxybenzoic acid+stool 0 -0.65034965 0 stool_bileacids stool_cometabolism 0.195 0.0536 no no no no dn no DCA+stool AGE-RAGE signaling pathway in diabetic complications 0 0 0.547148504 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Antigen processing and presentation 0 -0.754545455 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Apoptosis -0.783281734 0 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Breast cancer 0 0 0.436476567 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Butyricicoccus 0 0 0.436859765 butyrate-producing stool_bileacids Genus 0.195 0.852 no no no no no no DCA+stool CA+stool -0.517027864 0 0 stool_bileacids stool_bileacids 0.195 0.827 no no no no no no DCA+stool Carbon metabolism 0 -0.745454545 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool CDCA+stool -0.587203302 0 0 stool_bileacids stool_bileacids 0.195 0.663 no no no no no no DCA+stool Chemical carcinogenesis - receptor activation 0 0.718181818 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Choline metabolism in cancer 0 0.681818182 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Clostridium 0 -0.653157881 0 stool_bileacids Genus 0.195 0.925 no no no no no no DCA+stool Cocaine addiction 0 0.663636364 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Coprococcus 0 0 0.572134387 butyrate-producing stool_bileacids Genus 0.195 0.612 no no no no no no DCA+stool Coronavirus disease - COVID-19 0.533539732 0 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Cortisol synthesis and secretion 0 0.7 0 stool_bileacids kegg 0.195 NA no no no no no up DCA+stool Cushing syndrome 0 0.763636364 0 stool_bileacids kegg 0.195 NA no no no no no up DCA+stool Endocrine resistance 0 0.736363636 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Endocytosis -0.512899897 0 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Epithelial cell signaling in Helicobacter pylori infection -0.533539732 0 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Epstein-Barr virus infection 0 -0.672727273 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Fc gamma R-mediated phagocytosis -0.475748194 -0.690909091 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Fluid shear stress and atherosclerosis 0 -0.690909091 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool FoxO signaling pathway 0 0 0.470355731 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Fusobacterium 0 0 -0.527345237 stool_bileacids Genus 0.195 0.628 no no no no no no DCA+stool Gastric cancer 0 0.736363636 0.425183512 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Gemmiger 0.619514796 0 0 butyrate-producing stool_bileacids Genus 0.195 0.595 no no no no no no DCA+stool GnRH signaling pathway 0 0.718181818 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool "Growth hormone synthesis, secretion and action" 0 0.645454545 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Herpes simplex virus 1 infection 0 -0.672727273 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Human cytomegalovirus infection 0 -0.718181818 0 stool_bileacids kegg 0.195 NA no no no no no dn DCA+stool Human immunodeficiency virus 1 infection 0 -0.672727273 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Human papillomavirus infection -0.504643963 0 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Human T-cell leukemia virus 1 infection 0 -0.718181818 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Insulin secretion 0 0.681818182 0 yes stool_bileacids kegg 0.195 NA no no no no up up DCA+stool JAK-STAT signaling pathway 0 0 0.451157538 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Leishmaniasis 0 -0.663636364 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Leukocyte transendothelial migration 0 -0.727272727 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Lysosome -0.479876161 0 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Morphine addiction 0 0.727272727 0 stool_bileacids kegg 0.195 NA no no no no up up DCA+stool Natural killer cell mediated cytotoxicity -0.50877193 0 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Neuroactive ligand-receptor interaction 0 -0.727272727 0 stool_bileacids kegg 0.195 NA no no no up up up DCA+stool Neutrophil extracellular trap formation -0.698658411 -0.636363636 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool NOD-like receptor signaling pathway 0 0 0.549407115 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Odoribacter 0 -0.832167832 0 butyrate-producing stool_bileacids Genus 0.195 0.798 no no no no no no DCA+stool Oscillospira 0.663570691 0 0 LPS-producing stool_bileacids Genus 0.195 0.62 no no no no no no DCA+stool Osteoclast differentiation -0.539731682 0 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool p53 signaling pathway 0 0.781818182 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Pancreatic cancer 0 0 0.596837945 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Pathogenic Escherichia coli infection -0.620227038 -0.809090909 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Pathways in cancer 0 0.690909091 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Phagosome -0.537667699 -0.654545455 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Platinum drug resistance 0 0.645454545 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Prolactin signaling pathway 0 0 0.504234896 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Regulation of actin cytoskeleton 0 -0.609090909 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Ribosome 0.539731682 0 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Salmonella infection -0.473684211 -0.809090909 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Signaling pathways regulating pluripotency of stem cells 0 0.672727273 0.466967815 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Staphylococcus aureus infection 0 -0.645454545 0 stool_bileacids kegg 0.195 NA no no no up no no DCA+stool Tight junction 0 -0.672727273 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Tuberculosis 0 -0.663636364 0 stool_bileacids kegg 0.195 NA no no no no no dn DCA+stool Viral carcinogenesis -0.562435501 0 0 stool_bileacids kegg 0.195 NA no no no no no no DCA+stool Yersinia infection -0.611971104 0 0 stool_bileacids kegg 0.195 NA no no no no no no decanoic acid C10+blood 11-HETE+blood 0 0.493276281 0 serum_mcfa serum_ARA 6.64E-11 0.464 dn dn no no no no decanoic acid C10+blood 14:0/18:0-PC+blood 0 0.703431373 0 serum_mcfa serum_phospholipids 6.64E-11 0.00289 dn dn no up up no decanoic acid C10+blood 16:0/16:1-PC+blood 0 0.678921569 0 serum_mcfa serum_phospholipids 6.64E-11 0.00283 dn dn no up up no decanoic acid C10+blood 16:0/18:1-PE+blood -0.45112782 0.541666667 0 serum_mcfa serum_phospholipids 6.64E-11 0.000107 dn dn no up up no decanoic acid C10+blood 16:0/18:3-PC+blood -0.556390977 0 0 serum_mcfa serum_phospholipids 6.64E-11 0.00216 dn dn no no up up decanoic acid C10+blood 16:0/20:3-PC+blood 0 0.602941176 0 serum_mcfa serum_phospholipids 6.64E-11 5.43E-06 dn dn no no up up decanoic acid C10+blood 16:0/20:5-PC+blood 0 -0.713235294 0 serum_mcfa serum_phospholipids 6.64E-11 0.628 dn dn no no no no decanoic acid C10+blood 16:0/22:0-PE+blood 0 -0.607843137 0 serum_mcfa serum_phospholipids 6.64E-11 0.00839 dn dn no dn no up decanoic acid C10+blood 16:0/22:6-PC+blood 0 -0.617647059 0 serum_mcfa serum_phospholipids 6.64E-11 4.53E-05 dn dn no no up up decanoic acid C10+blood 16:1/18:1-PG+blood 0 0.482843137 0 serum_mcfa serum_phospholipids 6.64E-11 3.21E-05 dn dn no no up up decanoic acid C10+blood 18:0/18:1-PI+blood 0 0.666666667 0 serum_mcfa serum_phospholipids 6.64E-11 0.599 dn dn no no no no decanoic acid C10+blood 18:0/20:3-PC+blood 0 0.485294118 0 serum_mcfa serum_phospholipids 6.64E-11 0.0682 dn dn no no up no decanoic acid C10+blood 18:0/20:3-PI+blood 0 0.683823529 0 serum_mcfa serum_phospholipids 6.64E-11 0.377 dn dn no no no no decanoic acid C10+blood 18:0/20:4-PC+blood 0 -0.62745098 0 serum_mcfa serum_phospholipids 6.64E-11 0.454 dn dn no no no no decanoic acid C10+blood 18:0/20:5-PC+blood 0 -0.762254902 0 serum_mcfa serum_phospholipids 6.64E-11 0.17 dn dn no no no no decanoic acid C10+blood 18:0/22:6-PC+blood 0 -0.629901961 0 serum_mcfa serum_phospholipids 6.64E-11 0.0775 dn dn no no no up decanoic acid C10+blood 18:1-LPC+blood 0.452631579 0 0 serum_mcfa serum_phospholipids 6.64E-11 0.179 dn dn no no no no decanoic acid C10+blood 18:1-LPE+blood 0 0.519607843 0 serum_mcfa serum_phospholipids 6.64E-11 0.117 dn dn no no no no decanoic acid C10+blood 18:1/16:0-PE+blood -0.512781955 0 0 serum_mcfa serum_phospholipids 6.64E-11 0.000182 dn dn no up up no decanoic acid C10+blood 18:1/16:0-PI+blood 0 0.593137255 0 serum_mcfa serum_phospholipids 6.64E-11 0.793 dn dn no no no no decanoic acid C10+blood 18:1/16:1-PE+blood -0.479699248 0.507352941 0 serum_mcfa serum_phospholipids 6.64E-11 0.000184 dn dn no up up no decanoic acid C10+blood 18:1/18:0-PE+blood 0 0.5 0 serum_mcfa serum_phospholipids 6.64E-11 1.39E-06 dn dn no up up no decanoic acid C10+blood 18:1/18:1-PC+blood 0 0.737745098 0 serum_mcfa serum_phospholipids 6.64E-11 1.34E-05 dn dn no no up up decanoic acid C10+blood 18:1/18:1-PE+blood -0.448120301 0 0 serum_mcfa serum_phospholipids 6.64E-11 1.03E-05 dn dn no up up no decanoic acid C10+blood 18:1/18:1-PI+blood 0.523308271 0 0 serum_mcfa serum_phospholipids 6.64E-11 0.111 dn dn no dn no no decanoic acid C10+blood 18:1/18:2-PE+blood 0 0.487745098 0 serum_mcfa serum_phospholipids 6.64E-11 0.000293 dn dn no up up no decanoic acid C10+blood 18:1/20:3-PC+blood 0 0.610294118 0 serum_mcfa serum_phospholipids 6.64E-11 0.00872 dn dn no no up up decanoic acid C10+blood 18:1/20:4-PC+blood 0 -0.62745098 0 serum_mcfa serum_phospholipids 6.64E-11 0.582 dn dn no no no no decanoic acid C10+blood 18:1/20:4-PE+blood -0.446616541 0 0 serum_mcfa serum_phospholipids 6.64E-11 0.0578 dn dn no up no no decanoic acid C10+blood 18:2-LPC+blood 0.557894737 0 0 serum_mcfa serum_phospholipids 6.64E-11 0.00743 dn dn no dn no up decanoic acid C10+blood 18:2-LPE+blood 0 0.644607843 0 serum_mcfa serum_phospholipids 6.64E-11 0.112 dn dn no no no no decanoic acid C10+blood 18:2/18:2-PS+blood 0 0.669117647 0 serum_mcfa serum_phospholipids 6.64E-11 0.00674 dn dn no up up no decanoic acid C10+blood 18:3/16:0-PE+blood -0.751879699 0 -0.447521368 serum_mcfa serum_phospholipids 6.64E-11 0.00149 dn dn no up up no decanoic acid C10+blood 18:3n6+blood 0 0 -0.526837607 serum_mcfa serum_fattyacid 6.64E-11 0.0463 dn dn no up no dn decanoic acid C10+blood 2-methyl-butyric acid m-C4+blood 0.592481203 0 0 serum_mcfa serum_scfa 6.64E-11 0.262 dn dn no no no no decanoic acid C10+blood 20:0/20:5-PC+blood 0 -0.56372549 0 serum_mcfa serum_phospholipids 6.64E-11 0.882 dn dn no no no no decanoic acid C10+blood 20:2/18:1-PE+blood -0.452631579 0 0 serum_mcfa serum_phospholipids 6.64E-11 0.00208 dn dn no up up no decanoic acid C10+blood 20:2+blood 0 0.612745098 0 serum_mcfa serum_fattyacid 6.64E-11 0.478 dn dn no no no no decanoic acid C10+blood 20:3-LPC+blood 0 0.676470588 0 serum_mcfa serum_phospholipids 6.64E-11 0.0292 dn dn no no up no decanoic acid C10+blood 20:3-LPE+blood 0 0.647058824 0 serum_mcfa serum_phospholipids 6.64E-11 0.084 dn dn no no up no decanoic acid C10+blood 20:3n6+blood 0 0.767156863 0 serum_mcfa serum_fattyacid 6.64E-11 0.0884 dn dn no up no no decanoic acid C10+blood 20:4-LPC+blood 0 -0.671568627 0 serum_mcfa serum_phospholipids 6.64E-11 0.949 dn dn no no no no decanoic acid C10+blood 20:4n6+blood 0 -0.568627451 0 serum_mcfa serum_fattyacid 6.64E-11 0.133 dn dn no no no no decanoic acid C10+blood 20:5-LPC+blood 0 -0.838235294 0 serum_mcfa serum_phospholipids 6.64E-11 0.558 dn dn no no no no decanoic acid C10+blood 20:5n3+blood 0 -0.671568627 0 serum_mcfa serum_fattyacid 6.64E-11 0.988 dn dn no no no no decanoic acid C10+blood 22:6-LPC+blood 0 -0.725490196 0 serum_mcfa serum_phospholipids 6.64E-11 0.127 dn dn no no no up decanoic acid C10+blood 22:6n3+blood 0 -0.585784314 0 serum_mcfa serum_fattyacid 6.64E-11 0.792 dn dn no no no no decanoic acid C10+blood 9-HODE+blood 0 0 -0.513846154 serum_mcfa serum_ARA 6.64E-11 0.297 dn dn no no no no decanoic acid C10+blood AA+blood 0 0 -0.421538462 serum_mcfa serum_ARA 6.64E-11 0.212 dn dn no no no no decanoic acid C10+blood ACA+blood 0 -0.48659424 0 serum_mcfa serum_bileacids 6.64E-11 0.338 dn dn no no no no decanoic acid C10+blood capric acid C6+blood 0 0 0.621880342 serum_mcfa serum_scfa 6.64E-11 0.433 dn dn no no no no decanoic acid C10+blood Creatinine+blood 0.503759398 0 0 serum_mcfa serum_choline 6.64E-11 0.437 dn dn no no no no decanoic acid C10+blood d18:1-18:0-SM+blood 0 -0.588235294 0 serum_mcfa serum_phospholipids 6.64E-11 0.97 dn dn no no no no decanoic acid C10+blood d18:1-20:0-SM+blood -0.455639098 -0.490196078 0 serum_mcfa serum_phospholipids 6.64E-11 0.933 dn dn no no no no decanoic acid C10+blood d18:1-20:1-SM+blood 0 -0.487745098 0 serum_mcfa serum_phospholipids 6.64E-11 0.0992 dn dn no no no no Desulfovibrio Bilophila 0 0.462200405 0 Genus Genus 0.27 0.528 no no no no no no Desulfovibrio Turicibacter 0 0.404179525 0 Genus Genus 0.27 0.269 no no no no no no DHA+blood 12-HEPE+blood -0.488623089 0 0 serum_ARA serum_ARA 0.872 0.312 no no no no no no DHA+blood 14:0/18:2-PC+blood 0.577443609 0 0 serum_ARA serum_phospholipids 0.872 0.102 no no no no up no DHA+blood 14:0+blood 0.565413534 0 0 yes serum_ARA serum_fattyacid 0.872 0.00572 no no no up no dn DHA+blood 16:0/16:1-PC+blood 0 -0.485294118 0 serum_ARA serum_phospholipids 0.872 0.00283 no no no up up no DHA+blood 16:0/16:1-PI+blood 0 -0.605392157 0 serum_ARA serum_phospholipids 0.872 0.262 no no no no no no DHA+blood 16:0/18:1-PE+blood 0 -0.541666667 0 serum_ARA serum_phospholipids 0.872 0.000107 no no no up up no DHA+blood 16:0/18:2-PI+blood 0 -0.703431373 0 serum_ARA serum_phospholipids 0.872 0.269 no no no no no no DHA+blood 16:0/20:4-PC+blood 0 0.669117647 0 serum_ARA serum_phospholipids 0.872 0.0262 no no no no up no DHA+blood 16:0/20:4-PI+blood 0 -0.602941176 0 serum_ARA serum_phospholipids 0.872 0.558 no no no no no no DHA+blood 16:0/22:6-PC+blood 0 0.5 0 serum_ARA serum_phospholipids 0.872 4.53E-05 no no no no up up DHA+blood 18:0-LPC+blood 0 -0.517156863 0 serum_ARA serum_phospholipids 0.872 0.554 no no no no no no DHA+blood 18:0/18:0-PC+blood 0 -0.490196078 0 serum_ARA serum_phospholipids 0.872 0.426 no no no no no no DHA+blood 18:0/18:1-PC+blood 0 -0.553921569 0 serum_ARA serum_phospholipids 0.872 0.393 no no no no no no DHA+blood 18:0/18:1-PE+blood 0 -0.578431373 0 serum_ARA serum_phospholipids 0.872 0.00716 no no no up up no DHA+blood 18:0/18:1-PG+blood 0 -0.522058824 0 serum_ARA serum_phospholipids 0.872 0.000842 no no no no up no DHA+blood 18:0/20:2-PC+blood 0 -0.504901961 0 serum_ARA serum_phospholipids 0.872 0.733 no no no no no no DHA+blood 18:0/20:3-PC+blood 0 -0.649509804 0 serum_ARA serum_phospholipids 0.872 0.0682 no no no no up no DHA+blood 18:0/20:4-PC+blood 0 0.492647059 0 serum_ARA serum_phospholipids 0.872 0.454 no no no no no no DHA+blood 18:0/20:5-PC+blood 0 0.5 0 serum_ARA serum_phospholipids 0.872 0.17 no no no no no no DHA+blood 18:0/22:6-PC+blood 0.521804511 0 0 serum_ARA serum_phospholipids 0.872 0.0775 no no no no no up DHA+blood 18:0/22:6-PI+blood 0.631578947 0 0 serum_ARA serum_phospholipids 0.872 0.425 no no no no no no DHA+blood 18:1/16:0-PE+blood 0 -0.566176471 0 serum_ARA serum_phospholipids 0.872 0.000182 no no no up up no DHA+blood 18:1/16:1-PE+blood 0 -0.583333333 0 serum_ARA serum_phospholipids 0.872 0.000184 no no no up up no DHA+blood 18:1/18:0-PE+blood 0 -0.642156863 0 serum_ARA serum_phospholipids 0.872 1.39E-06 no no no up up no DHA+blood 18:1/18:0-PI+blood 0 -0.568627451 0 serum_ARA serum_phospholipids 0.872 0.0931 no no no no no up DHA+blood 18:1/18:1-PE+blood 0 -0.669117647 0 serum_ARA serum_phospholipids 0.872 1.03E-05 no no no up up no DHA+blood 18:1/18:1-PG+blood 0 -0.56127451 0 serum_ARA serum_phospholipids 0.872 0.00352 no no no no up up DHA+blood 18:1/18:2-PE+blood 0 -0.678921569 0 serum_ARA serum_phospholipids 0.872 0.000293 no no no up up no DHA+blood 18:2/16:0-PC+blood 0 0.482843137 0 serum_ARA serum_phospholipids 0.872 8.67E-05 no no no no up up DHA+blood 18:3n3+blood 0.661654135 0.629901961 0 serum_ARA serum_fattyacid 0.872 0.291 no no no no no no DHA+blood 20:0-LPE+blood 0 -0.575980392 0 serum_ARA serum_phospholipids 0.872 0.0615 no no no no no up DHA+blood 20:0/20:4-PE+blood 0 -0.651960784 0 serum_ARA serum_phospholipids 0.872 0.00128 no no no up up no DHA+blood 20:1/20:4-PC+blood 0.559398496 0 0 serum_ARA serum_phospholipids 0.872 0.0419 no no no no no up DHA+blood 20:1/20:4-PE+blood 0 -0.575980392 0 serum_ARA serum_phospholipids 0.872 0.0042 no no no up up no DHA+blood 20:1+blood -0.497744361 0 0 yes serum_ARA serum_fattyacid 0.872 2.56E-05 no no no dn dn dn DHA+blood 20:2/18:0-PC+blood 0 -0.659313725 0 serum_ARA serum_phospholipids 0.872 0.0427 no no no no up no DHA+blood 20:2/18:1-PE+blood 0 -0.81372549 0 serum_ARA serum_phospholipids 0.872 0.00208 no no no up up no DHA+blood 20:3/16:0-PC+blood 0 0.656862745 0 serum_ARA serum_phospholipids 0.872 0.00405 no no no no up up DHA+blood 20:3n6+blood 0 -0.549019608 0 serum_ARA serum_fattyacid 0.872 0.0884 no no no up no no DHA+blood 20:4-LPC+blood 0 0.62254902 0 serum_ARA serum_phospholipids 0.872 0.949 no no no no no no DHA+blood 20:4-LPE+blood 0 0.482843137 0 serum_ARA serum_phospholipids 0.872 0.552 no no no no no no DHA+blood 20:4n6+blood 0 0.546568627 0 serum_ARA serum_fattyacid 0.872 0.133 no no no no no no DHA+blood 20:5-LPC+blood 0 0.5 0 serum_ARA serum_phospholipids 0.872 0.558 no no no no no no DHA+blood 20:5/18:0-PC+blood 0.569924812 0.495098039 0 serum_ARA serum_phospholipids 0.872 3.97E-06 no no no no up up DHA+blood 22:1-LPA+blood 0.487218045 0 0 serum_ARA serum_phospholipids 0.872 0.00373 no no no no up up DHA+blood 22:6-LPC+blood 0 0.539215686 0 serum_ARA serum_phospholipids 0.872 0.127 no no no no no up DHA+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0.582417582 0 0 serum_ARA stool_cometabolism 0.872 0.33 no no no no no no DHA+blood AA+blood 0.509774436 0.862745098 0 serum_ARA serum_ARA 0.872 0.212 no no no no no no DHA+blood Adipocytokine signaling pathway -0.784210526 0 0 serum_ARA kegg 0.872 NA no no no no no no DHA+blood Axon guidance 0 -0.614705882 0 serum_ARA kegg 0.872 NA no no no no up up DHA+blood Betaine+blood 0 0.629901961 0 serum_ARA serum_choline 0.872 0.857 no no no no no no DHA+blood Cellular senescence 0 0 0.455384615 serum_ARA kegg 0.872 NA no no no no no no DHA+blood Central carbon metabolism in cancer 0.550877193 0 0 serum_ARA kegg 0.872 NA no no no no no no DHA+blood Choline+blood -0.44962406 0 0 serum_ARA serum_choline 0.872 0.0395 no no no no up no DHA+blood Collinsella 0 0 -0.402158929 serum_ARA Genus 0.872 0.128 no no no no no no DHA+blood d18:1-14:1-SM+blood 0 -0.585784314 0 serum_ARA serum_phospholipids 0.872 0.0952 no no no no dn no DHA+blood Estrogen signaling pathway 0.496491228 0 0 serum_ARA kegg 0.872 NA no no no no no no DHA+blood GCA+stool 0 0 -0.521804511 serum_ARA stool_bileacids 0.872 0.0809 no no no no no no DHA+blood Gemmiger 0 0 0.401027985 butyrate-producing serum_ARA Genus 0.872 0.595 no no no no no no DHA+blood Human papillomavirus infection 0 0 0.518461538 serum_ARA kegg 0.872 NA no no no no no no DHA+blood Longevity regulating pathway - multiple species 0.489473684 0 0 serum_ARA kegg 0.872 NA no no no no no no DHA+blood Measles 0 0.532352941 0 serum_ARA kegg 0.872 NA no no no no no no DHA+blood Odoribacter 0 0 0.473307212 butyrate-producing serum_ARA Genus 0.872 0.798 no no no no no no DHA+blood Primary immunodeficiency 0.635087719 0 0 serum_ARA kegg 0.872 NA no no no no no no DHA+blood Th1 and Th2 cell differentiation -0.515789474 0.561764706 0 serum_ARA kegg 0.872 NA no no no no no no DHA+blood Th17 cell differentiation 0 0.555882353 0 serum_ARA kegg 0.872 NA no no no no no no DHA+blood Toxoplasmosis 0 0.529411765 0 serum_ARA kegg 0.872 NA no no no no no no DHA+blood Viral carcinogenesis 0 0 0.476153846 serum_ARA kegg 0.872 NA no no no no no no Diabetic cardiomyopathy 2-Oxocarboxylic acid metabolism -0.553913043 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy ABC transporters -0.473043478 -0.436758893 0 kegg kegg NA NA no no no no up up Diabetic cardiomyopathy Acute myeloid leukemia 0 -0.502964427 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Adherens junction 0 0.679841897 0.636550837 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Adrenergic signaling in cardiomyocytes 0.730434783 0.798418972 0 kegg kegg NA NA no no no no no up Diabetic cardiomyopathy African trypanosomiasis 0 -0.460474308 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy AGE-RAGE signaling pathway in diabetic complications 0 -0.796442688 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy "Alanine, aspartate and glutamate metabolism" -0.506956522 -0.772727273 -0.516087516 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Aldosterone synthesis and secretion 0.579130435 0.752964427 0 kegg kegg NA NA no no no no up up Diabetic cardiomyopathy Allograft rejection -0.431304348 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy alpha-Linolenic acid metabolism -0.60173913 -0.763833992 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Alzheimer disease 0.979130435 0.994071146 0.953410553 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Amino sugar and nucleotide sugar metabolism -0.62173913 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Aminoacyl-tRNA biosynthesis -0.634782609 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Amoebiasis 0 -0.54743083 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Amphetamine addiction 0.51826087 0.740118577 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy AMPK signaling pathway 0 0.416996047 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Amyotrophic lateral sclerosis 0.968695652 0.966403162 0.948519949 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Apelin signaling pathway 0 0.757905138 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Apoptosis -0.41826087 -0.563241107 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Apoptosis - multiple species 0 -0.476284585 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Arginine and proline metabolism 0 -0.779644269 -0.572972973 kegg kegg NA NA no no no no up no Diabetic cardiomyopathy Arginine biosynthesis -0.519130435 -0.719367589 -0.475160875 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy 0 0.611660079 0.581981982 kegg kegg NA NA no no no no up up Diabetic cardiomyopathy Autoimmune thyroid disease -0.431304348 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Autophagy - animal 0 -0.716403162 -0.476705277 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Axon guidance 0.527826087 0 0 kegg kegg NA NA no no no no up up Diabetic cardiomyopathy B cell receptor signaling pathway 0 -0.603754941 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Bacterial invasion of epithelial cells 0 0.425889328 0.456628057 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Basal cell carcinoma 0.43826087 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy beta-Alanine metabolism -0.705217391 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Bile secretion 0.446956522 0.489130435 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Biosynthesis of amino acids -0.762608696 -0.635375494 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Biosynthesis of unsaturated fatty acids -0.428695652 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Bladder cancer 0 -0.739130435 -0.418018018 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Breast cancer 0 -0.649209486 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Butanoate metabolism -0.610434783 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Butyricimonas 0.412392684 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Diabetic cardiomyopathy C-type lectin receptor signaling pathway 0 -0.605731225 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Calcium signaling pathway 0.708695652 0.73715415 0 kegg kegg NA NA no no no no up up Diabetic cardiomyopathy cAMP signaling pathway 0.759130435 0 0 yes kegg kegg NA NA no no no no up up Diabetic cardiomyopathy Carbohydrate digestion and absorption 0 -0.456521739 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Carbon metabolism -0.724347826 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Cardiac muscle contraction 0.982608696 0.980237154 0.968854569 kegg kegg NA NA no no no no no up Diabetic cardiomyopathy Cell adhesion molecules -0.509565217 -0.41798419 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy cGMP-PKG signaling pathway 0 -0.621541502 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Chagas disease 0 -0.463438735 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Chemical carcinogenesis - DNA adducts -0.450434783 -0.501976285 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Chemical carcinogenesis - receptor activation 0.454782609 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Chemokine signaling pathway 0 -0.43083004 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Choline metabolism in cancer 0 -0.467391304 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Circadian entrainment 0 0.587944664 0 kegg kegg NA NA no no no no up up Diabetic cardiomyopathy Circadian rhythm 0.613043478 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Citrate cycle (TCA cycle) 0 0.415019763 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Cocaine addiction 0 0.472332016 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Colorectal cancer 0.613913043 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Complement and coagulation cascades -0.517391304 -0.627470356 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Coronavirus disease - COVID-19 0.674782609 0.876482213 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Cushing syndrome 0.430434783 0.434782609 0 kegg kegg NA NA no no no no no up Diabetic cardiomyopathy Cysteine and methionine metabolism 0 0.482213439 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Cytokine-cytokine receptor interaction 0 -0.42687747 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Dilated cardiomyopathy 0 0.701581028 0.498069498 kegg kegg NA NA no no no no up up Diabetic cardiomyopathy DNA replication 0 0.43083004 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Dopaminergic synapse 0.622608696 0.707509881 0 kegg kegg NA NA no no no no up no Diabetic cardiomyopathy Drug metabolism - cytochrome P450 0 0.486166008 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Drug metabolism - other enzymes -0.547826087 0.561264822 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy EGFR tyrosine kinase inhibitor resistance 0 0.693675889 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Endocrine and other factor-regulated calcium reabsorption 0.52173913 0.786561265 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Endocytosis -0.423478261 -0.447628458 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Epithelial cell signaling in Helicobacter pylori infection 0 -0.550395257 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy ErbB signaling pathway 0 -0.427865613 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Ether lipid metabolism 0.646086957 0.441699605 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Fat digestion and absorption -0.462608696 -0.614624506 0 yes kegg kegg NA NA no no no no up up Diabetic cardiomyopathy Fatty acid biosynthesis 0 -0.800395257 -0.545688546 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Fatty acid degradation -0.626086957 -0.860671937 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Fatty acid elongation -0.479130435 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Fatty acid metabolism -0.724347826 -0.827075099 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Fc epsilon RI signaling pathway 0 -0.690711462 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Fc gamma R-mediated phagocytosis -0.409565217 -0.626482213 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Focal adhesion 0 0.535573123 0.51042471 kegg kegg NA NA no no no no up up Diabetic cardiomyopathy Folate biosynthesis 0 0.440711462 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy FoxO signaling pathway 0 -0.76284585 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Fructose and mannose metabolism -0.766086957 -0.59486166 -0.501415701 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy GABAergic synapse 0 -0.640316206 0 kegg kegg NA NA no no no no up up Diabetic cardiomyopathy Galactose metabolism -0.742608696 -0.76284585 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Gastric acid secretion 0 0.726284585 0.594594595 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Glioma 0.445217391 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Glucagon signaling pathway 0 0.746047431 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Glutathione metabolism 0 0.688735178 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Glycerolipid metabolism 0 -0.636363636 0 kegg kegg NA NA no no no no no up Diabetic cardiomyopathy Glycerophospholipid metabolism 0 -0.414031621 0 kegg kegg NA NA no no no no no up Diabetic cardiomyopathy Glycolysis / Gluconeogenesis -0.622608696 0.458498024 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.748023715 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Glycosaminoglycan biosynthesis - keratan sulfate 0.508695652 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Glycosaminoglycan degradation 0 -0.423913043 0 kegg kegg NA NA no no no no no up Diabetic cardiomyopathy Glyoxylate and dicarboxylate metabolism -0.648695652 -0.723320158 -0.537709138 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy GnRH signaling pathway 0 0.469367589 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Graft-versus-host disease -0.433913043 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Hedgehog signaling pathway 0.480869565 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Hepatitis B 0 -0.801383399 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Hepatocellular carcinoma 0 0.611660079 0.619305019 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy HIF-1 signaling pathway 0 0.664031621 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Hippo signaling pathway 0 0.654150198 0.62985843 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Hippo signaling pathway - multiple species 0 -0.742094862 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Human papillomavirus infection -0.464347826 -0.416007905 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Huntington disease 0.977391304 0.990118577 0.948777349 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Hypertrophic cardiomyopathy 0 0.554347826 0.526640927 kegg kegg NA NA no no no no up up Diabetic cardiomyopathy IL-17 signaling pathway 0 -0.529644269 -0.416731017 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Inflammatory mediator regulation of TRP channels 0.519130435 0.803359684 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Inositol phosphate metabolism 0 -0.486166008 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Insulin resistance 0 -0.54743083 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Insulin secretion 0 0.510869565 0 yes kegg kegg NA NA no no no no up up Diabetic cardiomyopathy Insulin signaling pathway 0 0.70256917 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy JAK-STAT signaling pathway 0 -0.757905138 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Kaposi sarcoma-associated herpesvirus infection 0 0.449604743 0 kegg kegg NA NA no no no no no dn Diabetic cardiomyopathy Legionellosis -0.413913043 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Leishmaniasis -0.533913043 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Long-term depression 0.582608696 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Mannose type O-glycan biosynthesis 0.434782609 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy MAPK signaling pathway 0 -0.683794466 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Melanogenesis 0.508695652 0.835968379 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Melanoma 0 -0.456521739 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Metabolism of xenobiotics by cytochrome P450 0 0.442687747 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy MicroRNAs in cancer 0 -0.618577075 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Mineral absorption 0.416521739 0.600790514 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Mitophagy - animal 0.500869565 0.802371542 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Morphine addiction 0.532173913 0.593873518 0 kegg kegg NA NA no no no no up up Diabetic cardiomyopathy mRNA surveillance pathway 0.680869565 0.635375494 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy mTOR signaling pathway 0 0.684782609 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Mucin type O-glycan biosynthesis 0 -0.427865613 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy N-Glycan biosynthesis 0 0.552371542 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Natural killer cell mediated cytotoxicity -0.417391304 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Neuroactive ligand-receptor interaction 0 -0.495059289 0 kegg kegg NA NA no no no up up up Diabetic cardiomyopathy Neurotrophin signaling pathway 0.549565217 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Neutrophil extracellular trap formation -0.423478261 -0.502964427 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy NF-kappa B signaling pathway 0 -0.730237154 -0.403088803 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Nicotinate and nicotinamide metabolism 0 -0.735177866 -0.464092664 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Nitrogen metabolism -0.43826087 -0.623517787 -0.463320463 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy NOD-like receptor signaling pathway 0 -0.760869565 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Non-alcoholic fatty liver disease 0.966086957 0.953557312 0.877220077 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Non-homologous end-joining -0.629565217 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Non-small cell lung cancer 0 -0.416996047 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Olfactory transduction 0 -0.576086957 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Oocyte meiosis 0.416521739 0.461462451 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Oscillospira 0 -0.520750988 0 LPS-producing kegg Genus NA 0.62 no no no no no no Diabetic cardiomyopathy Osteoclast differentiation 0 -0.704545455 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Other glycan degradation 0 -0.532608696 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Oxidative phosphorylation 0.988695652 0.998023715 0.990990991 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Pancreatic secretion 0.673913043 0.720355731 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Pantothenate and CoA biosynthesis 0 -0.776679842 -0.453796654 kegg kegg NA NA no no no no no dn Diabetic cardiomyopathy "Parathyroid hormone synthesis, secretion and action" 0.644347826 0.791501976 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Parkinson disease 0.810434783 0.956521739 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Pathways in cancer 0.557391304 -0.435770751 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Pathways of neurodegeneration - multiple diseases 0.812173913 0.946640316 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.543478261 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Pentose and glucuronate interconversions 0 0.528656126 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Pentose phosphate pathway -0.460869565 -0.538537549 -0.421879022 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Peroxisome -0.573913043 -0.736166008 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Pertussis 0 -0.654150198 0 kegg kegg NA NA no no no no no dn Diabetic cardiomyopathy Phagosome -0.533043478 -0.420948617 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Phosphatidylinositol signaling system 0.517391304 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Phospholipase D signaling pathway 0 -0.54743083 0 kegg kegg NA NA no no no no up up Diabetic cardiomyopathy Phototransduction 0 0.538537549 0.429086229 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Platelet activation 0 0.54743083 0.429086229 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy PPAR signaling pathway 0 -0.595849802 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Primary immunodeficiency -0.444347826 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Prion disease 0.964347826 0.977272727 0.96036036 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Prolactin signaling pathway 0 -0.619565217 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Propanoate metabolism 0 0.456521739 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Proteasome 0 0.494071146 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Protein digestion and absorption -0.633913043 -0.837944664 -0.43011583 yes kegg kegg NA NA no no no no up up Diabetic cardiomyopathy Protein export 0.480869565 0.773715415 0.445045045 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Protein processing in endoplasmic reticulum 0 0.610671937 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Proteoglycans in cancer 0 0.736166008 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Proximal tubule bicarbonate reclamation 0 0.473320158 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Purine metabolism 0 0.41798419 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Pyrimidine metabolism -0.728695652 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Pyruvate metabolism 0 0.574110672 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Rap1 signaling pathway 0 0.444664032 0.438095238 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Ras signaling pathway 0 0.519762846 0 yes kegg kegg NA NA no no no no up up Diabetic cardiomyopathy Regulation of actin cytoskeleton 0 0 0.411583012 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Relaxin signaling pathway 0.504347826 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Renal cell carcinoma 0.514782609 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Renin secretion 0 0.813241107 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Renin-angiotensin system 0 -0.570158103 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Retinol metabolism -0.471304348 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Retrograde endocannabinoid signaling 0.833913043 0.929841897 0.77992278 kegg kegg NA NA no no no no no up Diabetic cardiomyopathy Rheumatoid arthritis 0 -0.567193676 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Ribosome 0.673043478 0.881422925 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy RIG-I-like receptor signaling pathway 0 -0.685770751 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy RNA degradation 0.63826087 0.669960474 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy RNA polymerase 0 0.541501976 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy RNA transport 0 0.575098814 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Shigellosis 0.5 0.824110672 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Signaling pathways regulating pluripotency of stem cells 0.571304348 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Small cell lung cancer 0 -0.524703557 0 kegg kegg NA NA no no no no no up Diabetic cardiomyopathy SNARE interactions in vesicular transport 0 -0.698616601 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Sphingolipid signaling pathway 0.450434783 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Staphylococcus aureus infection -0.493043478 -0.450592885 0 kegg kegg NA NA no no no up no no Diabetic cardiomyopathy Starch and sucrose metabolism -0.452173913 -0.809288538 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Sulfur metabolism -0.457391304 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Synaptic vesicle cycle 0 -0.538537549 0 kegg kegg NA NA no no no no up up Diabetic cardiomyopathy Systemic lupus erythematosus -0.42 -0.440711462 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy T cell receptor signaling pathway 0 -0.510869565 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Taurine and hypotaurine metabolism 0 -0.425889328 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy TGF-beta signaling pathway 0.703478261 0.685770751 0.41029601 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Th17 cell differentiation 0 -0.419960474 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Thermogenesis 0.953913043 0.986166008 0.941312741 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Thiamine metabolism 0 0.421936759 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Thyroid hormone signaling pathway 0 0.646245059 0.624710425 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Thyroid hormone synthesis 0 0.592885375 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Tight junction 0 0.537549407 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy TNF signaling pathway 0 -0.54743083 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Toll-like receptor signaling pathway 0 -0.635375494 0 yes kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Toxoplasmosis 0 -0.617588933 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Transcriptional misregulation in cancer 0 -0.701581028 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Tryptophan metabolism -0.554782609 0 0 kegg kegg NA NA no no no no up no Diabetic cardiomyopathy Tuberculosis -0.44173913 -0.553359684 0 kegg kegg NA NA no no no no no dn Diabetic cardiomyopathy Type I diabetes mellitus -0.431304348 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Type II diabetes mellitus 0 -0.598814229 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Ubiquinone and other terpenoid-quinone biosynthesis -0.412173913 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Ubiquitin mediated proteolysis 0.490434783 0.81027668 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy "Valine, leucine and isoleucine degradation" -0.493913043 0 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Vascular smooth muscle contraction 0.693043478 0.858695652 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Vasopressin-regulated water reabsorption 0.550434783 0.758893281 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Vibrio cholerae infection 0 0.619565217 0.502445302 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Viral carcinogenesis 0 -0.488142292 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Vitamin digestion and absorption 0.617391304 -0.428853755 0 kegg kegg NA NA no no no no no no Diabetic cardiomyopathy Wnt signaling pathway 0.69826087 0.645256917 0.415701416 kegg kegg NA NA no no no no no no Diastolic_Pressure+clinic 15-HETE+blood 0 0 0.405449495 clinic serum_ARA 0.0346 0.819 up no no no no no Diastolic_Pressure+clinic 16:0/16:1-PC+blood 0 -0.596428571 0 clinic serum_phospholipids 0.0346 0.00283 up no no up up no Diastolic_Pressure+clinic 16:0/18:2-PI+blood 0 -0.660714286 0 clinic serum_phospholipids 0.0346 0.269 up no no no no no Diastolic_Pressure+clinic 16:0/18:3-PC+blood 0.496388029 0 0 clinic serum_phospholipids 0.0346 0.00216 up no no no up up Diastolic_Pressure+clinic 16:0/22:6-PC+blood 0 0.528571429 0 clinic serum_phospholipids 0.0346 4.53E-05 up no no no up up Diastolic_Pressure+clinic 16:1/18:2-PG+blood 0 -0.678571429 0 clinic serum_phospholipids 0.0346 1.40E-08 up no no no up up Diastolic_Pressure+clinic 18:0-LPA+blood 0 0 -0.401538462 clinic serum_phospholipids 0.0346 0.0725 up no no no dn no Diastolic_Pressure+clinic 18:0/18:2-PI+blood 0 -0.557142857 0 clinic serum_phospholipids 0.0346 0.179 up no no no no no Diastolic_Pressure+clinic 18:0/20:4-PC+blood 0 0.639285714 0 clinic serum_phospholipids 0.0346 0.454 up no no no no no Diastolic_Pressure+clinic 18:0/20:5-PC+blood 0 0.75 0 clinic serum_phospholipids 0.0346 0.17 up no no no no no Diastolic_Pressure+clinic 18:1/18:1-PE+blood 0 -0.653571429 0 clinic serum_phospholipids 0.0346 1.03E-05 up no no up up no Diastolic_Pressure+clinic 18:1/18:2-PI+blood 0 0 -0.409230769 clinic serum_phospholipids 0.0346 0.0164 up no no dn no up Diastolic_Pressure+clinic 18:1/20:4-PC+blood 0 0.689285714 0 clinic serum_phospholipids 0.0346 0.582 up no no no no no Diastolic_Pressure+clinic 20:1-LPA+blood 0 0 -0.427692308 clinic serum_phospholipids 0.0346 0.0187 up no no dn dn no Diastolic_Pressure+clinic 20:3n6+blood 0 -0.596428571 0 clinic serum_fattyacid 0.0346 0.0884 up no no up no no Diastolic_Pressure+clinic 20:4-LPC+blood 0 0.564285714 0 clinic serum_phospholipids 0.0346 0.949 up no no no no no Diastolic_Pressure+clinic "3-(3,4-dihydroxyphenyl)propionic acid+urine" -0.473684211 0 0 clinic urine_cometabolism 0.0346 0.0125 up no no up up no Diastolic_Pressure+clinic 4-hydroxybenzoic acid+urine 0 0.487745098 0 clinic urine_cometabolism 0.0346 0.52 up no no no no no Diastolic_Pressure+clinic 9-HODE+blood 0 0 0.54 clinic serum_ARA 0.0346 0.297 up no no no no no Diastolic_Pressure+clinic AA+blood 0 0.607142857 0 clinic serum_ARA 0.0346 0.212 up no no no no no Diastolic_Pressure+clinic ACA+stool -0.511968578 0 0 clinic stool_bileacids 0.0346 0.417 up no no no no no Diastolic_Pressure+clinic Aldosterone synthesis and secretion -0.50310559 0 0 clinic kegg 0.0346 NA up no no no up up Diastolic_Pressure+clinic Amphetamine addiction -0.439864483 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Anaerostipes 0.518833588 0 0 butyrate-producing clinic Genus 0.0346 0.568 up no no no no no Diastolic_Pressure+clinic Antigen processing and presentation 0.5256917 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Breast cancer -0.477131564 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic C-peptide -0.469367589 -0.623941276 -0.449656226 clinic DM-assocaited hormones 0.0346 0.228 up no no no no no Diastolic_Pressure+clinic CA+blood 0 0 0.496528798 clinic serum_bileacids 0.0346 0.606 up no no no no no Diastolic_Pressure+clinic Chemical carcinogenesis - receptor activation -0.512140034 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Choline metabolism in cancer -0.454545455 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Choline+blood -0.545923633 0 -0.406153846 clinic serum_choline 0.0346 0.0395 up no no no up no Diastolic_Pressure+clinic Colorectal cancer -0.51552795 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Cushing syndrome -0.587803501 0 0 clinic kegg 0.0346 NA up no no no no up Diastolic_Pressure+clinic Dorea 0.47826087 0 0 clinic Genus 0.0346 0.00362 up no no up no dn Diastolic_Pressure+clinic Endocrine resistance -0.57312253 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic EPA+blood 0 0.657142857 0 clinic serum_ARA 0.0346 0.212 up no no no no no Diastolic_Pressure+clinic ErbB signaling pathway -0.482778091 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Gastric cancer -0.549407115 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic GCDCA+stool 0 -0.627272727 0 yes clinic stool_bileacids 0.0346 0.0471 up no no no dn no Diastolic_Pressure+clinic Glycolysis / Gluconeogenesis 0.460191982 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic GnRH signaling pathway -0.498588368 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic "Growth hormone synthesis, secretion and action" -0.631846414 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Herpes simplex virus 1 infection 0.541501976 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Human T-cell leukemia virus 1 infection 0.505364201 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic IL-17 signaling pathway 0 0 -0.434733894 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Kaposi sarcoma-associated herpesvirus infection -0.488424619 -0.484415584 0 clinic kegg 0.0346 NA up no no no no dn Diastolic_Pressure+clinic L-2-Aminobutyric acid+blood 0 0.521428571 0 yes clinic serum_aminoacids 0.0346 0.000328 up no no up up no Diastolic_Pressure+clinic L-Isoleucine+blood 0 0 -0.583846154 yes clinic serum_aminoacids 0.0346 5.47E-06 up no no up up no Diastolic_Pressure+clinic L-Leucine+blood 0 0 -0.466923077 yes clinic serum_aminoacids 0.0346 3.22E-05 up no no up up no Diastolic_Pressure+clinic L-Phenylalanine+blood 0 -0.525 -0.546153846 yes clinic serum_aminoacids 0.0346 0.0103 up no no up up no Diastolic_Pressure+clinic L-Proline+blood 0 -0.742857143 0 yes clinic serum_aminoacids 0.0346 0.00265 up no no up up no Diastolic_Pressure+clinic L-Tryptophan+blood 0 -0.564285714 0 clinic serum_aminoacids 0.0346 0.164 up no no no no no Diastolic_Pressure+clinic L-Tyrosine+blood 0 -0.557142857 0 yes clinic serum_aminoacids 0.0346 0.00913 up no no up up no Diastolic_Pressure+clinic Legionellosis 0.43083004 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Leishmaniasis 0.471485037 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Long-term depression -0.424054207 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Long-term potentiation 0 0.580519481 0 clinic kegg 0.0346 NA up no no no no up Diastolic_Pressure+clinic Longevity regulating pathway -0.501976285 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Morphine addiction -0.479390175 0 0 clinic kegg 0.0346 NA up no no no up up Diastolic_Pressure+clinic Necroptosis 0 -0.457142857 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Parabacteroides 0 0.578769057 0 clinic Genus 0.0346 4.19E-05 up no no no up up Diastolic_Pressure+clinic Primary immunodeficiency 0.57312253 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic RANTES 0 0 0.618226601 yes clinic serum_cytokines 0.0346 0.0757 up no no no no up Diastolic_Pressure+clinic Regulation of actin cytoskeleton 0.451157538 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Relaxin signaling pathway -0.450028233 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Retrograde endocannabinoid signaling 0 0 0.407002801 clinic kegg 0.0346 NA up no no no no up Diastolic_Pressure+clinic Roseburia 0 -0.53374755 0 butyrate-producing clinic Genus 0.0346 0.495 up no no no no no Diastolic_Pressure+clinic Salmonella infection 0.436476567 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic Signaling pathways regulating pluripotency of stem cells -0.477131564 0 0 clinic kegg 0.0346 NA up no no no no no Diastolic_Pressure+clinic TCA+stool 0.533925627 0 0 clinic stool_bileacids 0.0346 0.458 up no no no no no Diastolic_Pressure+clinic TXB2+blood 0 0.73217828 0 yes clinic serum_ARA 0.0346 0.0644 up no no dn no no Diastolic_Pressure+clinic Valine+blood -0.475748194 0 -0.645384615 yes clinic serum_aminoacids 0.0346 1.22E-06 up no no up up no Diastolic_Pressure+clinic Visfatin 0 0 0.463101604 clinic DM-assocaited hormones 0.0346 0.0229 up no no dn no up Diastolic_Pressure+clinic Wnt signaling pathway -0.473743648 0 0 clinic kegg 0.0346 NA up no no no no no Dilated cardiomyopathy 2-Oxocarboxylic acid metabolism 0 0.450592885 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy ABC transporters 0 -0.475296443 0 kegg kegg NA NA no up up no up up Dilated cardiomyopathy Adherens junction 0.893043478 0.92687747 0.803603604 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Adipocytokine signaling pathway 0 -0.492094862 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Adrenergic signaling in cardiomyocytes 0 0.563241107 0 kegg kegg NA NA no up up no no up Dilated cardiomyopathy AGE-RAGE signaling pathway in diabetic complications 0 -0.638339921 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy "Alanine, aspartate and glutamate metabolism" 0 -0.730237154 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Aldosterone synthesis and secretion 0 0.493083004 0 kegg kegg NA NA no up up no up up Dilated cardiomyopathy alpha-Linolenic acid metabolism 0 -0.492094862 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Alzheimer disease 0 0.698616601 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Amoebiasis 0 0 0.507335907 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Amphetamine addiction 0 0.509881423 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Amyotrophic lateral sclerosis 0 0.716403162 0.525353925 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Apelin signaling pathway -0.469565217 0.486166008 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Apoptosis 0.41826087 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Apoptosis - multiple species -0.570434783 -0.557312253 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Arginine and proline metabolism 0 -0.640316206 0 kegg kegg NA NA no up up no up no Dilated cardiomyopathy Arginine biosynthesis 0 -0.654150198 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy 0.967826087 0.961462451 0.825482625 kegg kegg NA NA no up up no up up Dilated cardiomyopathy Ascorbate and aldarate metabolism 0 0.416007905 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Autophagy - animal -0.780869565 -0.867588933 -0.524324324 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Autophagy - other -0.87826087 -0.735177866 -0.522779923 kegg kegg NA NA no up up no no no Dilated cardiomyopathy B cell receptor signaling pathway 0 -0.554347826 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Bacterial invasion of epithelial cells 0.833913043 0.793478261 0.736164736 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Basal transcription factors -0.666086957 0 -0.421621622 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Base excision repair -0.539130435 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Bifidobacterium 0 0.418030009 0 acetate-producing kegg Genus NA 0.105 no up up no dn no Dilated cardiomyopathy Bile secretion 0.490434783 0.616600791 0.454826255 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Biosynthesis of amino acids 0 -0.422924901 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Biosynthesis of cofactors 0.462608696 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Bladder cancer 0 -0.574110672 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Breast cancer -0.433913043 -0.694664032 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Butanoate metabolism 0 0.424901186 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy C-type lectin receptor signaling pathway -0.573043478 -0.652173913 -0.416216216 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Calcium signaling pathway 0 0.622529644 0 kegg kegg NA NA no up up no up up Dilated cardiomyopathy Carbohydrate digestion and absorption -0.527826087 -0.427865613 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Cardiac muscle contraction 0 0.718379447 0.493178893 kegg kegg NA NA no up up no no up Dilated cardiomyopathy Central carbon metabolism in cancer -0.462608696 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy cGMP-PKG signaling pathway 0 -0.42687747 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Chagas disease 0 -0.504940711 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Choline metabolism in cancer -0.457391304 -0.501976285 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Cholinergic synapse -0.450434783 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Chronic myeloid leukemia -0.45826087 -0.463438735 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Circadian entrainment 0.453043478 0.726284585 0.501930502 kegg kegg NA NA no up up no up up Dilated cardiomyopathy Circadian rhythm -0.602608696 0 -0.404633205 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Citrate cycle (TCA cycle) 0 0.416996047 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Coronavirus disease - COVID-19 0 0.544466403 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Cytokine-cytokine receptor interaction 0 0 0.604118404 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Dopaminergic synapse 0 0.647233202 0 kegg kegg NA NA no up up no up no Dilated cardiomyopathy Drug metabolism - cytochrome P450 0 0.601778656 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Drug metabolism - other enzymes 0 0.691699605 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy EGFR tyrosine kinase inhibitor resistance -0.473043478 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Endocrine and other factor-regulated calcium reabsorption 0.407826087 0.693675889 0.508622909 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Endometrial cancer 0 -0.538537549 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Epithelial cell signaling in Helicobacter pylori infection 0 -0.462450593 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy ErbB signaling pathway -0.426956522 -0.489130435 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Estrogen signaling pathway 0 0.449604743 0.447104247 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Fatty acid biosynthesis 0 -0.668972332 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Fatty acid degradation 0 -0.688735178 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Fatty acid metabolism 0 -0.641304348 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Fc epsilon RI signaling pathway 0 -0.553359684 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Fc gamma R-mediated phagocytosis 0 -0.421936759 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Focal adhesion 0.874782609 0.873517787 0.744144144 kegg kegg NA NA no up up no up up Dilated cardiomyopathy Folate biosynthesis 0 0.419960474 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy FoxO signaling pathway -0.433043478 -0.753952569 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy GABAergic synapse -0.41826087 -0.517786561 0 kegg kegg NA NA no up up no up up Dilated cardiomyopathy Galactose metabolism 0 -0.456521739 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Gap junction 0.596521739 0 0.653539254 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Gastric acid secretion 0.926086957 0.975296443 0.938481338 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Glioma -0.462608696 -0.496047431 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Glucagon signaling pathway 0 0.537549407 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Glutathione metabolism 0 0.553359684 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Glycerolipid metabolism 0 -0.544466403 0 kegg kegg NA NA no up up no no up Dilated cardiomyopathy Glycerophospholipid metabolism -0.471304348 -0.510869565 0 kegg kegg NA NA no up up no no up Dilated cardiomyopathy "Glycine, serine and threonine metabolism" 0.451304348 0 0 kegg kegg NA NA no up up no up no Dilated cardiomyopathy Glycolysis / Gluconeogenesis 0 0.469367589 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.618577075 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.472173913 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Glyoxylate and dicarboxylate metabolism 0 -0.673913043 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy GnRH secretion 0 -0.459486166 0 kegg kegg NA NA no up up no up up Dilated cardiomyopathy Hepatitis B -0.665217391 -0.842885375 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Hepatitis C 0 -0.519762846 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Hepatocellular carcinoma 0.849565217 0.922924901 0.694980695 kegg kegg NA NA no up up no no no Dilated cardiomyopathy HIF-1 signaling pathway -0.56173913 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Hippo signaling pathway 0.860869565 0.884387352 0.765508366 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Hippo signaling pathway - multiple species 0 -0.585968379 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Huntington disease 0 0.710474308 0.462033462 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Hypertrophic cardiomyopathy 0.956521739 0.949604743 0.836550837 kegg kegg NA NA no up up no up up Dilated cardiomyopathy Inflammatory mediator regulation of TRP channels 0 0.666007905 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Influenza A 0.48173913 0 0.544401544 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Inositol phosphate metabolism 0 -0.530632411 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Insulin resistance -0.688695652 -0.641304348 -0.536936937 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Insulin signaling pathway -0.542608696 0 -0.436036036 kegg kegg NA NA no up up no no no Dilated cardiomyopathy JAK-STAT signaling pathway 0 -0.717391304 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Lachnospira 0 0.533234511 0 butyrate-producing kegg Genus NA 0.279 no up up no no no Dilated cardiomyopathy Leukocyte transendothelial migration 0.686086957 0.543478261 0.644015444 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Linoleic acid metabolism 0 0.432806324 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Long-term depression 0 0 0.475418275 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Long-term potentiation -0.466086957 0 0 kegg kegg NA NA no up up no no up Dilated cardiomyopathy Lysine degradation -0.474782609 0 -0.42033462 kegg kegg NA NA no up up no no no Dilated cardiomyopathy MAPK signaling pathway 0 -0.647233202 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Measles -0.435652174 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Melanogenesis 0.453043478 0.682806324 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Melanoma -0.575652174 -0.647233202 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Metabolism of xenobiotics by cytochrome P450 0 0.602766798 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy MicroRNAs in cancer 0 -0.722332016 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Mitophagy - animal 0 0.448616601 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Morphine addiction 0 0.666996047 0.462548263 kegg kegg NA NA no up up no up up Dilated cardiomyopathy mRNA surveillance pathway -0.473043478 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy mTOR signaling pathway -0.46 0 -0.446332046 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Mucin type O-glycan biosynthesis 0 -0.636363636 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy N-Glycan biosynthesis 0 0.526679842 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Neurotrophin signaling pathway -0.410434783 -0.513833992 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy NF-kappa B signaling pathway -0.486086957 -0.73715415 -0.442471042 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Nicotinate and nicotinamide metabolism 0 -0.604743083 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Nitrogen metabolism 0 -0.617588933 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy NOD-like receptor signaling pathway 0 -0.777667984 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Non-alcoholic fatty liver disease 0 0.624505929 0.517374517 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Non-small cell lung cancer -0.426956522 -0.431818182 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Oscillospira 0 -0.45256917 0 LPS-producing kegg Genus NA 0.62 no up up no no no Dilated cardiomyopathy Osteoclast differentiation 0 -0.624505929 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Other glycan degradation 0 -0.449604743 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Other types of O-glycan biosynthesis -0.47826087 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Ovarian steroidogenesis 0.607826087 0 0.519433719 kegg kegg NA NA no up up no up up Dilated cardiomyopathy Oxidative phosphorylation 0 0.709486166 0.4996139 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Oxytocin signaling pathway 0.877391304 0.716403162 0.697297297 kegg kegg NA NA no up up no no no Dilated cardiomyopathy p53 signaling pathway -0.68 -0.522727273 -0.403088803 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Pancreatic secretion 0 0.766798419 0.509395109 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Pantothenate and CoA biosynthesis 0 -0.631422925 0 kegg kegg NA NA no up up no no dn Dilated cardiomyopathy Paraprevotella 0 0.443448839 0 kegg Genus NA 0.118 no up up no no no Dilated cardiomyopathy "Parathyroid hormone synthesis, secretion and action" 0 0.45256917 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Parkinson disease 0 0.631422925 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Pathogenic Escherichia coli infection 0 0 0.543371943 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Pathways in cancer -0.482608696 -0.479249012 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Pathways of neurodegeneration - multiple diseases 0 0.598814229 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy PD-L1 expression and PD-1 checkpoint pathway in cancer -0.56 -0.765810277 -0.51969112 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Pentose and glucuronate interconversions 0 0.470355731 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Peroxisome 0 -0.701581028 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Pertussis 0 -0.419960474 0 kegg kegg NA NA no up up no no dn Dilated cardiomyopathy Phagosome 0.455652174 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Phenylalanine metabolism 0.657391304 0.599802372 0.447361647 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Phosphatidylinositol signaling system -0.433043478 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Phototransduction 0 0.475296443 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy PI3K-Akt signaling pathway -0.429565217 0 0 yes kegg kegg NA NA no up up no up up Dilated cardiomyopathy Platelet activation 0.951304348 0.920948617 0.934877735 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Platinum drug resistance -0.619130435 -0.494071146 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Porphyrin and chlorophyll metabolism 0.42173913 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy PPAR signaling pathway 0 -0.660079051 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Prion disease 0 0.692687747 0.486743887 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Progesterone-mediated oocyte maturation -0.624347826 -0.460474308 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Prolactin signaling pathway 0 -0.518774704 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Prostate cancer -0.54173913 -0.543478261 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Proteasome -0.625217391 0 -0.484942085 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Protein digestion and absorption 0 -0.670948617 0 yes kegg kegg NA NA no up up no up up Dilated cardiomyopathy Protein export -0.527826087 0.527667984 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Protein processing in endoplasmic reticulum 0 0.454545455 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Proteoglycans in cancer 0 0.543478261 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Proximal tubule bicarbonate reclamation 0 0.51284585 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Pyrimidine metabolism 0 0.484189723 -0.499099099 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Rap1 signaling pathway 0.839130435 0.842885375 0.855855856 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Ras signaling pathway 0 0.581027668 0 yes kegg kegg NA NA no up up no up up Dilated cardiomyopathy Regulation of actin cytoskeleton 0.617391304 0.558300395 0.556499356 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Regulation of lipolysis in adipocytes 0 0.434782609 0.47953668 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Renin secretion 0.486086957 0.743083004 0.444015444 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Retrograde endocannabinoid signaling 0 0.731225296 0 kegg kegg NA NA no up up no no up Dilated cardiomyopathy Ribosome 0 0.552371542 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Ribosome biogenesis in eukaryotes -0.474782609 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy RIG-I-like receptor signaling pathway -0.626956522 -0.766798419 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy RNA degradation -0.487826087 0.463438735 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy RNA polymerase -0.560869565 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Salivary secretion 0.486086957 0.624505929 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Salmonella infection 0 0 0.544144144 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Selenocompound metabolism -0.610434783 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Serotonergic synapse 0.436521739 0 0.534105534 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Shigellosis 0 0.460474308 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Small cell lung cancer -0.495652174 -0.608695652 0 kegg kegg NA NA no up up no no up Dilated cardiomyopathy SNARE interactions in vesicular transport 0 -0.691699605 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Spinocerebellar ataxia -0.84173913 0 -0.434491634 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Spliceosome -0.657391304 -0.483201581 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Starch and sucrose metabolism 0 -0.62055336 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Sulfur metabolism 0.406956522 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy T cell receptor signaling pathway 0 -0.747035573 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Taurine and hypotaurine metabolism 0 -0.482213439 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Terpenoid backbone biosynthesis -0.454782609 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy TGF-beta signaling pathway 0 0.502964427 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Th17 cell differentiation 0 -0.420948617 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Thermogenesis 0 0.716403162 0.457142857 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Thiamine metabolism 0 0 -0.461776062 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Thyroid hormone signaling pathway 0.819130435 0.943675889 0.681853282 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Thyroid hormone synthesis 0 0.476284585 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Tight junction 0.743478261 0.796442688 0.54980695 kegg kegg NA NA no up up no no no Dilated cardiomyopathy TNF signaling pathway -0.422608696 -0.595849802 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Toll-like receptor signaling pathway 0 -0.613636364 0 yes kegg kegg NA NA no up up no no no Dilated cardiomyopathy Transcriptional misregulation in cancer -0.842608696 -0.828063241 -0.48957529 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Type II diabetes mellitus -0.497391304 -0.647233202 -0.404118404 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Tyrosine metabolism 0 0.496047431 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Ubiquitin mediated proteolysis 0 0.475296443 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Various types of N-glycan biosynthesis -0.433043478 0 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Vascular smooth muscle contraction 0 0.750988142 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Vasopressin-regulated water reabsorption 0.446956522 0.75 0.592020592 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Vibrio cholerae infection 0.927826087 0.957509881 0.866666667 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Viral protein interaction with cytokine and cytokine receptor 0 0 0.518146718 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Wnt signaling pathway 0 0.542490119 0 kegg kegg NA NA no up up no no no Dilated cardiomyopathy Yersinia infection 0.42173913 0 0.626512227 kegg kegg NA NA no up up no no no DL-Indole-3-lactic acid+urine 14:0/18:2-PC+blood 0 0.78021978 0 urine_cometabolism serum_phospholipids 0.00552 0.102 up up no no up no DL-Indole-3-lactic acid+urine 18:2n6c+blood -0.531862745 0 0 urine_cometabolism serum_fattyacid 0.00552 0.15 up up no no no no DL-Indole-3-lactic acid+urine 2-hydroxyphenylacetic acid+urine -0.460150376 0 0 urine_cometabolism urine_cometabolism 0.00552 0.763 up up no no no no DL-Indole-3-lactic acid+urine 20:1+blood 0.485294118 0 0 yes urine_cometabolism serum_fattyacid 0.00552 2.56E-05 up up no dn dn dn DL-Indole-3-lactic acid+urine 20:2+blood 0 0.708791209 0 urine_cometabolism serum_fattyacid 0.00552 0.478 up up no no no no DL-Indole-3-lactic acid+urine 20:4-LPC+blood 0.676470588 0 0 urine_cometabolism serum_phospholipids 0.00552 0.949 up up no no no no DL-Indole-3-lactic acid+urine 20:4n6+blood 0.705882353 0 0 urine_cometabolism serum_fattyacid 0.00552 0.133 up up no no no no DL-Indole-3-lactic acid+urine 24:0+blood 0 0.615384615 0 urine_cometabolism serum_fattyacid 0.00552 0.034 up up no dn no up DL-Indole-3-lactic acid+urine "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0.559398496 0.519298246 0.688888889 urine_cometabolism urine_cometabolism 0.00552 0.0125 up up no up up no DL-Indole-3-lactic acid+urine 3-Hydroxy-L-kynurenine+urine 0 0.612280702 0 urine_cometabolism urine_cometabolism 0.00552 0.401 up up no no no no DL-Indole-3-lactic acid+urine 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.433162393 urine_cometabolism urine_cometabolism 0.00552 0.0405 up up no no dn dn DL-Indole-3-lactic acid+urine Alcoholism 0 0 0.434615385 urine_cometabolism kegg 0.00552 NA up up no no no no DL-Indole-3-lactic acid+urine Bacteroides 0.503759398 0 0 LPS-producing urine_cometabolism Genus 0.00552 0.000267 up up no dn dn up DL-Indole-3-lactic acid+urine Butyricicoccus 0 -0.457083118 0 butyrate-producing urine_cometabolism Genus 0.00552 0.852 up up no no no no DL-Indole-3-lactic acid+urine Calcium signaling pathway 0 0.470175439 0 urine_cometabolism kegg 0.00552 NA up up no no up up DL-Indole-3-lactic acid+urine Clostridium 0 -0.549582541 0 urine_cometabolism Genus 0.00552 0.925 up up no no no no DL-Indole-3-lactic acid+urine Collinsella 0 -0.572935858 0 urine_cometabolism Genus 0.00552 0.128 up up no no no no DL-Indole-3-lactic acid+urine d18:0-16:0-SM+blood 0.50245098 0 0 urine_cometabolism serum_phospholipids 0.00552 0.202 up up no no no no DL-Indole-3-lactic acid+urine d18:0-24:1-SM+blood 0.482843137 0 0 urine_cometabolism serum_phospholipids 0.00552 0.0609 up up no no dn dn DL-Indole-3-lactic acid+urine d18:1-14:0-SM+blood 0.551470588 0 0 urine_cometabolism serum_phospholipids 0.00552 0.94 up up no no no no DL-Indole-3-lactic acid+urine d18:1-16:0-SM+blood 0.49754902 0 0 urine_cometabolism serum_phospholipids 0.00552 0.14 up up no no no no DL-Indole-3-lactic acid+urine d18:1-16:1-SM+blood 0.504901961 0 0 urine_cometabolism serum_phospholipids 0.00552 0.2 up up no no no no DL-Indole-3-lactic acid+urine d18:1-22:1-SM+blood 0.517156863 0 0 urine_cometabolism serum_phospholipids 0.00552 0.222 up up no no no no DL-Indole-3-lactic acid+urine Endocrine resistance 0 0.494736842 0 urine_cometabolism kegg 0.00552 NA up up no no no no DL-Indole-3-lactic acid+urine Gap junction 0 0.619298246 0 urine_cometabolism kegg 0.00552 NA up up no no no no DL-Indole-3-lactic acid+urine Glutamatergic synapse -0.498245614 0 0 urine_cometabolism kegg 0.00552 NA up up no no up up DL-Indole-3-lactic acid+urine Long-term depression 0 0.678947368 0 urine_cometabolism kegg 0.00552 NA up up no no no no DL-Indole-3-lactic acid+urine Morphine addiction 0 0.528070175 0 urine_cometabolism kegg 0.00552 NA up up no no up up DL-Indole-3-lactic acid+urine n6+blood 0 0.582417582 0 urine_cometabolism serum_fattyacid 0.00552 0.153 up up no no no no DL-Indole-3-lactic acid+urine NF-kappa B signaling pathway 0.512280702 0 0 urine_cometabolism kegg 0.00552 NA up up no no no no DL-Indole-3-lactic acid+urine Parkinson disease 0 0 0.434615385 urine_cometabolism kegg 0.00552 NA up up no no no no DL-Indole-3-lactic acid+urine Pathways of neurodegeneration - multiple diseases 0 0 0.453076923 urine_cometabolism kegg 0.00552 NA up up no no no no DL-Indole-3-lactic acid+urine Regulation of lipolysis in adipocytes 0 0.571929825 0 urine_cometabolism kegg 0.00552 NA up up no no no no DL-Indole-3-lactic acid+urine Renin secretion -0.496491228 0 0 urine_cometabolism kegg 0.00552 NA up up no no no no DL-Indole-3-lactic acid+urine Salivary secretion -0.529824561 0.478947368 0 urine_cometabolism kegg 0.00552 NA up up no no no no DL-Indole-3-lactic acid+urine Thyroid hormone synthesis 0 0.489473684 0 urine_cometabolism kegg 0.00552 NA up up no no no no DL-methionine sulfoxide+blood 14:0/18:2-PC+blood 0 -0.519607843 0 serum_aminoacids serum_phospholipids 0.302 0.102 no no no no up no DL-methionine sulfoxide+blood 14:0/20:4-PC+blood 0 -0.558823529 0 serum_aminoacids serum_phospholipids 0.302 0.486 no no no no no no DL-methionine sulfoxide+blood 16:0/16:0-PC+blood -0.455639098 0 0 serum_aminoacids serum_phospholipids 0.302 0.00079 no no no no up up DL-methionine sulfoxide+blood 16:0/18:0-PC+blood 0 -0.492647059 0 serum_aminoacids serum_phospholipids 0.302 0.521 no no no no no no DL-methionine sulfoxide+blood 16:0/18:3-PC+blood 0 -0.742647059 0 serum_aminoacids serum_phospholipids 0.302 0.00216 no no no no up up DL-methionine sulfoxide+blood 16:0/20:5-PC+blood 0 -0.68627451 0 serum_aminoacids serum_phospholipids 0.302 0.628 no no no no no no DL-methionine sulfoxide+blood 18:1-LPE+blood 0 0.575980392 0 serum_aminoacids serum_phospholipids 0.302 0.117 no no no no no no DL-methionine sulfoxide+blood 18:2-LPA+blood -0.445112782 0 0 serum_aminoacids serum_phospholipids 0.302 0.00684 no no no dn no up DL-methionine sulfoxide+blood 18:3/18:2-PC+blood 0 -0.529411765 -0.538461538 serum_aminoacids serum_phospholipids 0.302 0.0394 no no no no no up DL-methionine sulfoxide+blood 20:0+blood 0 0 0.439316239 yes serum_aminoacids serum_fattyacid 0.302 0.000278 no no no dn no up DL-methionine sulfoxide+blood 20:3/18:0-PC+blood 0 0 -0.423589744 serum_aminoacids serum_phospholipids 0.302 0.296 no no no no no no DL-methionine sulfoxide+blood 20:5-LPC+blood 0 0 0.446153846 serum_aminoacids serum_phospholipids 0.302 0.558 no no no no no no DL-methionine sulfoxide+blood 20:5n3+blood 0 -0.573529412 0 serum_aminoacids serum_fattyacid 0.302 0.988 no no no no no no DL-methionine sulfoxide+blood ACA+blood 0 0 -0.439056476 serum_aminoacids serum_bileacids 0.302 0.338 no no no no no no DL-methionine sulfoxide+blood Choline+blood 0 0 0.401025641 serum_aminoacids serum_choline 0.302 0.0395 no no no no up no DL-methionine sulfoxide+blood Creatinine+blood 0 0.659313725 0 serum_aminoacids serum_choline 0.302 0.437 no no no no no no DL-methionine sulfoxide+blood Cystine+blood 0 0.713235294 0 yes serum_aminoacids serum_aminoacids 0.302 0.00028 no no no up up no DL-methionine sulfoxide+blood d18:0-18:3-SM+blood 0 0 -0.455726496 serum_aminoacids serum_phospholipids 0.302 0.0879 no no no no dn no DL-methionine sulfoxide+blood DCA+stool -0.571428571 0 0 serum_aminoacids stool_bileacids 0.302 0.195 no no no no no no DMG+blood 12-HEPE+blood 0 -0.612531804 0 serum_choline serum_ARA 0.909 0.312 no no no no no no DMG+blood 14:0+blood -0.464661654 0 0 yes serum_choline serum_fattyacid 0.909 0.00572 no no no up no dn DMG+blood 16:0/18:2-PC+blood 0 0 0.522051282 serum_choline serum_phospholipids 0.909 3.24E-06 no no no no up up DMG+blood 16:0/20:5-PC+blood 0 -0.590686275 0 serum_choline serum_phospholipids 0.909 0.628 no no no no no no DMG+blood 16:0/22:6-PC+blood 0 0 0.44957265 serum_choline serum_phospholipids 0.909 4.53E-05 no no no no up up DMG+blood 16:1/16:0-PC+blood 0 0 0.411965812 serum_choline serum_phospholipids 0.909 0.0215 no no no no up up DMG+blood 18:0/18:2-PC+blood 0 0 0.508376068 serum_choline serum_phospholipids 0.909 1.74E-06 no no no no up up DMG+blood 18:0/20:4-PI+blood 0 -0.644607843 0 serum_choline serum_phospholipids 0.909 0.167 no no no no no no DMG+blood 18:0+blood 0 -0.580882353 0 serum_choline serum_fattyacid 0.909 0.344 no no no no no no DMG+blood 18:1/16:0-PC+blood 0 0 0.532307692 serum_choline serum_phospholipids 0.909 2.43E-05 no no no no up up DMG+blood 18:1/16:0-PI+blood -0.473684211 0 0 serum_choline serum_phospholipids 0.909 0.793 no no no no no no DMG+blood 18:1/18:0-PC+blood 0 0 0.483076923 serum_choline serum_phospholipids 0.909 1.83E-06 no no no no up up DMG+blood 18:1/18:0-PS+blood 0 -0.676470588 0 serum_choline serum_phospholipids 0.909 0.193 no no no no no no DMG+blood 18:2-LPA+blood 0 0.482843137 0 serum_choline serum_phospholipids 0.909 0.00684 no no no dn no up DMG+blood 18:2/16:0-PC+blood 0 0 0.519316239 serum_choline serum_phospholipids 0.909 8.67E-05 no no no no up up DMG+blood 18:2/20:4-PC+blood 0 -0.517156863 0 serum_choline serum_phospholipids 0.909 0.0145 no no no no no up DMG+blood 20:1/20:4-PC+blood 0 0 0.448888889 serum_choline serum_phospholipids 0.909 0.0419 no no no no no up DMG+blood 20:3/16:0-PC+blood 0 0 0.408547009 serum_choline serum_phospholipids 0.909 0.00405 no no no no up up DMG+blood 20:3/18:0-PI+blood 0 -0.615196078 0 serum_choline serum_phospholipids 0.909 0.289 no no no no no no DMG+blood 20:5n3+blood 0 -0.708333333 0 serum_choline serum_fattyacid 0.909 0.988 no no no no no no DMG+blood 22:6n3+blood 0 -0.519607843 0 serum_choline serum_fattyacid 0.909 0.792 no no no no no no DMG+blood 24:0+blood 0 0 -0.476239316 serum_choline serum_fattyacid 0.909 0.034 no no no dn no up DMG+blood 4-hydroxybenzoic acid+stool 0.664835165 0 0 serum_choline stool_cometabolism 0.909 0.0536 no no no no dn no DMG+blood "9,10-EPOME+blood" -0.629945993 0 0 serum_choline serum_ARA 0.909 0.801 no no no no no no DMG+blood Adherens junction 0 0.505882353 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Alistipes 0 -0.595953515 0 serum_choline Genus 0.909 0.0114 no no no no up no DMG+blood Bacterial invasion of epithelial cells 0 0.538235294 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Betaine+blood 0.508270677 0 0 serum_choline serum_choline 0.909 0.857 no no no no no no DMG+blood Bifidobacterium 0 0.705089035 0 acetate-producing serum_choline Genus 0.909 0.105 no no no no dn no DMG+blood Breast cancer 0 -0.585294118 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Choline+blood 0.542857143 0.482843137 0 serum_choline serum_choline 0.909 0.0395 no no no no up no DMG+blood Colorectal cancer 0 -0.667647059 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Creatinine+blood 0 0.568627451 0.429059829 serum_choline serum_choline 0.909 0.437 no no no no no no DMG+blood d18:0-24:1-SM+blood 0 0 -0.441367521 serum_choline serum_phospholipids 0.909 0.0609 no no no no dn dn DMG+blood d18:1-14:0-SM+blood 0 0 -0.441367521 serum_choline serum_phospholipids 0.909 0.94 no no no no no no DMG+blood d18:1-14:1-SM+blood 0 0 -0.431794872 serum_choline serum_phospholipids 0.909 0.0952 no no no no dn no DMG+blood d18:1-18:0-SM+blood 0 0 0.412649573 serum_choline serum_phospholipids 0.909 0.97 no no no no no no DMG+blood DCA+stool -0.703296703 0 0 serum_choline stool_bileacids 0.909 0.195 no no no no no no DMG+blood Dilated cardiomyopathy 0 0.564705882 -0.411538462 serum_choline kegg 0.909 NA no no no no up up DMG+blood DL-methionine sulfoxide+blood 0.609022556 0 0 serum_choline serum_aminoacids 0.909 0.302 no no no no no no DMG+blood ErbB signaling pathway 0 -0.647058824 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Estrogen signaling pathway -0.515789474 0 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood FoxO signaling pathway 0 -0.605882353 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Gastric acid secretion 0 0.594117647 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Gastric cancer 0 -0.679411765 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Hepatocellular carcinoma 0 0 -0.461538462 serum_choline kegg 0.909 NA no no no no no no DMG+blood Hippo signaling pathway 0 0 -0.401538462 serum_choline kegg 0.909 NA no no no no no no DMG+blood Influenza A 0 0.508823529 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood LCA+stool -0.565934066 0 0 serum_choline stool_bileacids 0.909 0.314 no no no no no no DMG+blood MAPK signaling pathway 0 -0.573529412 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Non-small cell lung cancer 0 -0.561764706 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Oxytocin signaling pathway 0 0.638235294 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Pancreatic cancer 0.459649123 -0.626470588 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Phosphatidylinositol signaling system 0 -0.555882353 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Platelet activation 0 0.541176471 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Platinum drug resistance 0 -0.579411765 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Progesterone-mediated oocyte maturation 0 -0.670588235 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Rap1 signaling pathway 0 0.547058824 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Serotonergic synapse -0.594736842 0 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Signaling pathways regulating pluripotency of stem cells 0 -0.65 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Spliceosome 0 -0.588235294 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood TGF-beta signaling pathway 0.468421053 0 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Thyroid hormone signaling pathway 0 0.502941176 -0.506923077 serum_choline kegg 0.909 NA no no no no no no DMG+blood Tight junction 0 0.594117647 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Vascular smooth muscle contraction 0 0.535294118 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Vibrio cholerae infection 0 0.679411765 0 serum_choline kegg 0.909 NA no no no no no no DMG+blood Wnt signaling pathway 0.570175439 0 0 serum_choline kegg 0.909 NA no no no no no no DNA replication 2-Oxocarboxylic acid metabolism 0.502608696 0.824110672 0.503989704 kegg kegg NA NA no no no no no no DNA replication ABC transporters 0.442608696 0 0.405405405 kegg kegg NA NA no no no no up up DNA replication "Alanine, aspartate and glutamate metabolism" 0 -0.685770751 0 kegg kegg NA NA no no no no no no DNA replication Aminoacyl-tRNA biosynthesis 0.706086957 0.786561265 0.62960103 kegg kegg NA NA no no no no no no DNA replication Antifolate resistance 0.449565217 0.630434783 0.466666667 kegg kegg NA NA no no no no no no DNA replication Arginine and proline metabolism 0 -0.752964427 0 kegg kegg NA NA no no no no up no DNA replication Arginine biosynthesis 0 -0.730237154 -0.505019305 kegg kegg NA NA no no no no no no DNA replication Ascorbate and aldarate metabolism 0.434782609 0.498023715 0.636036036 kegg kegg NA NA no no no no no no DNA replication Basal transcription factors 0.697391304 0.661067194 0.826769627 kegg kegg NA NA no no no no no no DNA replication beta-Alanine metabolism 0 0.522727273 0 kegg kegg NA NA no no no no no no DNA replication Biosynthesis of amino acids 0 -0.611660079 -0.518146718 kegg kegg NA NA no no no no no no DNA replication Biosynthesis of cofactors 0 0.622529644 0 kegg kegg NA NA no no no no no no DNA replication Biosynthesis of unsaturated fatty acids 0.617391304 0.4743083 0 kegg kegg NA NA no no no no no no DNA replication Butanoate metabolism 0.629565217 0.876482213 0.626512227 kegg kegg NA NA no no no no no no DNA replication Citrate cycle (TCA cycle) 0.779130435 0.886363636 0.783783784 kegg kegg NA NA no no no no no no DNA replication Cysteine and methionine metabolism 0.747826087 0.817193676 0.671042471 kegg kegg NA NA no no no no no no DNA replication Drug metabolism - cytochrome P450 0 0.887351779 0 kegg kegg NA NA no no no no no no DNA replication Drug metabolism - other enzymes 0 0.723320158 0 kegg kegg NA NA no no no no no no DNA replication EGFR tyrosine kinase inhibitor resistance 0.454782609 0.503952569 0.599227799 kegg kegg NA NA no no no no no no DNA replication Ether lipid metabolism 0 0.508893281 0.627541828 kegg kegg NA NA no no no no no no DNA replication Fatty acid biosynthesis 0 -0.68972332 0 kegg kegg NA NA no no no no no no DNA replication Fatty acid elongation 0 0.446640316 0 kegg kegg NA NA no no no no no no DNA replication Folate biosynthesis 0.427826087 0.454545455 0 kegg kegg NA NA no no no no no no DNA replication Glutathione metabolism 0 0.481225296 0 kegg kegg NA NA no no no no no no DNA replication Glycerolipid metabolism 0 0 0.461518662 kegg kegg NA NA no no no no no up DNA replication Glycerophospholipid metabolism 0 0 0.566280566 kegg kegg NA NA no no no no no up DNA replication Glycolysis / Gluconeogenesis 0.408695652 0.563241107 0 kegg kegg NA NA no no no no no no DNA replication Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.52 -0.658102767 0 kegg kegg NA NA no no no no no no DNA replication Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.614624506 0.453281853 kegg kegg NA NA no no no no no no DNA replication Glycosaminoglycan degradation -0.624347826 -0.438735178 0 kegg kegg NA NA no no no no no up DNA replication Glycosphingolipid biosynthesis - ganglio series 0 0.705533597 0.403346203 kegg kegg NA NA no no no no no no DNA replication Glycosphingolipid biosynthesis - globo and isoglobo series 0 0 -0.407979408 kegg kegg NA NA no no no no no no DNA replication Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.577391304 0 0 kegg kegg NA NA no no no no no no DNA replication Glyoxylate and dicarboxylate metabolism 0 -0.742094862 -0.447104247 kegg kegg NA NA no no no no no no DNA replication Inositol phosphate metabolism 0 0 0.487516088 kegg kegg NA NA no no no no no no DNA replication Linoleic acid metabolism 0 0.459486166 0.406177606 kegg kegg NA NA no no no no no no DNA replication Lysine degradation 0.448695652 0 0.581209781 kegg kegg NA NA no no no no no no DNA replication Mannose type O-glycan biosynthesis 0 0 0.482110682 kegg kegg NA NA no no no no no no DNA replication Metabolism of xenobiotics by cytochrome P450 0 0.838932806 0 kegg kegg NA NA no no no no no no DNA replication mRNA surveillance pathway 0 0.583992095 0.54028314 kegg kegg NA NA no no no no no no DNA replication Mucin type O-glycan biosynthesis 0.5 0 0 kegg kegg NA NA no no no no no no DNA replication N-Glycan biosynthesis 0.665217391 0.834980237 0.635521236 kegg kegg NA NA no no no no no no DNA replication Nicotinate and nicotinamide metabolism 0 -0.764822134 -0.425225225 kegg kegg NA NA no no no no no no DNA replication Nitrogen metabolism -0.50173913 -0.759881423 -0.57992278 kegg kegg NA NA no no no no no no DNA replication One carbon pool by folate 0.885217391 0.896245059 0.802316602 kegg kegg NA NA no no no no no no DNA replication Other types of O-glycan biosynthesis 0.452173913 0 0.628571429 kegg kegg NA NA no no no no no no DNA replication Oxidative phosphorylation 0 0.42687747 0 kegg kegg NA NA no no no no no no DNA replication Pantothenate and CoA biosynthesis 0 -0.581027668 0 kegg kegg NA NA no no no no no dn DNA replication Pentose and glucuronate interconversions 0.585217391 0.891304348 0.662548263 kegg kegg NA NA no no no no no no DNA replication Pentose phosphate pathway -0.497391304 -0.661067194 -0.494723295 kegg kegg NA NA no no no no no no DNA replication Phenylalanine metabolism 0 0.780632411 0 kegg kegg NA NA no no no no no no DNA replication Platinum drug resistance 0.557391304 0 0.441698842 kegg kegg NA NA no no no no no no DNA replication Primary bile acid biosynthesis 0.795652174 0.4743083 0 kegg kegg NA NA no no no no no no DNA replication Propanoate metabolism 0.716521739 0.758893281 0.672072072 kegg kegg NA NA no no no no no no DNA replication Pyrimidine metabolism 0.428695652 0.806324111 0 kegg kegg NA NA no no no no no no DNA replication Pyruvate metabolism 0.833913043 0.825098814 0.568082368 kegg kegg NA NA no no no no no no DNA replication Retinol metabolism 0.553913043 0.779644269 0.682368082 kegg kegg NA NA no no no no no no DNA replication Ribosome 0 0.442687747 0.437580438 kegg kegg NA NA no no no no no no DNA replication Ribosome biogenesis in eukaryotes 0.793913043 0.852766798 0.82007722 kegg kegg NA NA no no no no no no DNA replication RNA degradation 0 0.723320158 0.621364221 kegg kegg NA NA no no no no no no DNA replication RNA polymerase 0.653043478 0.855731225 0.824967825 kegg kegg NA NA no no no no no no DNA replication RNA transport 0.594782609 0.490118577 0 kegg kegg NA NA no no no no no no DNA replication Selenocompound metabolism 0.55826087 0.464426877 0.74980695 kegg kegg NA NA no no no no no no DNA replication Sphingolipid metabolism -0.611304348 0 0 kegg kegg NA NA no no no no no no DNA replication Starch and sucrose metabolism 0 -0.535573123 0 kegg kegg NA NA no no no no no no DNA replication Steroid biosynthesis 0.542608696 0.700592885 0.628828829 kegg kegg NA NA no no no no no no DNA replication Steroid hormone biosynthesis 0.408695652 0.671936759 0.502445302 kegg kegg NA NA no no no no no no DNA replication Synthesis and degradation of ketone bodies 0.882608696 0.846837945 0.77039897 kegg kegg NA NA no no no no no no DNA replication Terpenoid backbone biosynthesis 0.720869565 0.630434783 0.754440154 kegg kegg NA NA no no no no no no DNA replication Thiamine metabolism 0.43826087 0.587944664 0 kegg kegg NA NA no no no no no no DNA replication Tryptophan metabolism 0.64 0.709486166 0.538738739 kegg kegg NA NA no no no no up no DNA replication Tyrosine metabolism 0.564347826 0.822134387 0.476962677 kegg kegg NA NA no no no no no no DNA replication Ubiquinone and other terpenoid-quinone biosynthesis 0.693043478 0.87944664 0.852252252 kegg kegg NA NA no no no no no no DNA replication "Valine, leucine and isoleucine degradation" 0.824347826 0.884387352 0.708880309 kegg kegg NA NA no no no no no no DNA replication Various types of N-glycan biosynthesis 0.542608696 0.747035573 0.625997426 kegg kegg NA NA no no no no no no Dopaminergic synapse 2-Oxocarboxylic acid metabolism -0.606086957 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse ABC transporters -0.58173913 0 0 kegg kegg NA NA no up no no up up Dopaminergic synapse Adherens junction 0 0.530632411 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Adrenergic signaling in cardiomyocytes 0.889565217 0.783596838 0.904761905 kegg kegg NA NA no up no no no up Dopaminergic synapse "Alanine, aspartate and glutamate metabolism" -0.409565217 -0.593873518 -0.453024453 kegg kegg NA NA no up no no no no Dopaminergic synapse alpha-Linolenic acid metabolism -0.751304348 -0.558300395 -0.607979408 kegg kegg NA NA no up no no no no Dopaminergic synapse Amino sugar and nucleotide sugar metabolism -0.523478261 0 -0.523037323 kegg kegg NA NA no up no no no no Dopaminergic synapse Aminoacyl-tRNA biosynthesis -0.579130435 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse AMPK signaling pathway 0 0.425889328 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Apelin signaling pathway 0 0.593873518 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Apoptosis -0.436521739 -0.616600791 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Arginine and proline metabolism 0 -0.507905138 0 kegg kegg NA NA no up no no up no Dopaminergic synapse Arginine biosynthesis -0.427826087 -0.552371542 -0.428056628 kegg kegg NA NA no up no no no no Dopaminergic synapse Ascorbate and aldarate metabolism 0 0 -0.40952381 kegg kegg NA NA no up no no no no Dopaminergic synapse Autophagy - animal 0 -0.614624506 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Autophagy - other 0 -0.435770751 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Axon guidance 0.429565217 0 0 kegg kegg NA NA no up no no up up Dopaminergic synapse B cell receptor signaling pathway 0 -0.622529644 0 kegg kegg NA NA no up no no no no Dopaminergic synapse beta-Alanine metabolism -0.76173913 0 -0.506563707 kegg kegg NA NA no up no no no no Dopaminergic synapse Biosynthesis of amino acids -0.684347826 -0.550395257 -0.583011583 kegg kegg NA NA no up no no no no Dopaminergic synapse Biosynthesis of cofactors 0 0.5 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Blautia 0 -0.416996047 0 acetate-producing kegg Genus NA 1.36E-05 no up no up dn dn Dopaminergic synapse Butanoate metabolism -0.611304348 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Butyricimonas 0.476400418 0 0 butyrate-producing kegg Genus NA 0.17 no up no no no no Dopaminergic synapse C-type lectin receptor signaling pathway 0 -0.73715415 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Calcium signaling pathway 0.688695652 0.666007905 0.738481338 kegg kegg NA NA no up no no up up Dopaminergic synapse cAMP signaling pathway 0.81826087 0 0.60952381 yes kegg kegg NA NA no up no no up up Dopaminergic synapse Carbon metabolism -0.653043478 0 -0.654311454 kegg kegg NA NA no up no no no no Dopaminergic synapse Cardiac muscle contraction 0.626086957 0.664031621 0 kegg kegg NA NA no up no no no up Dopaminergic synapse Cell adhesion molecules -0.500869565 -0.604743083 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Cellular senescence 0 -0.583003953 0 kegg kegg NA NA no up no no no no Dopaminergic synapse cGMP-PKG signaling pathway 0 -0.461462451 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Circadian entrainment 0.731304348 0.861660079 0.723294723 kegg kegg NA NA no up no no up up Dopaminergic synapse Circadian rhythm 0.60173913 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Citrate cycle (TCA cycle) -0.42 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Complement and coagulation cascades -0.503478261 -0.428853755 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Coprococcus 0 0 -0.559238047 butyrate-producing kegg Genus NA 0.612 no up no no no no Dopaminergic synapse Drug metabolism - cytochrome P450 0 0.449604743 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Drug metabolism - other enzymes -0.56173913 0.437747036 0 kegg kegg NA NA no up no no no no Dopaminergic synapse ECM-receptor interaction 0 0 0.509137709 kegg kegg NA NA no up no no up up Dopaminergic synapse EGFR tyrosine kinase inhibitor resistance 0 0.467391304 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Endocrine resistance 0.61826087 0.468379447 0.615958816 kegg kegg NA NA no up no no no no Dopaminergic synapse Endocytosis 0 -0.565217391 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Ether lipid metabolism 0.416521739 0.464426877 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Fatty acid biosynthesis 0 -0.614624506 -0.437323037 kegg kegg NA NA no up no no no no Dopaminergic synapse Fatty acid degradation -0.622608696 -0.636363636 -0.674903475 kegg kegg NA NA no up no no no no Dopaminergic synapse Fatty acid elongation -0.551304348 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Fatty acid metabolism -0.680869565 -0.556324111 -0.572458172 kegg kegg NA NA no up no no no no Dopaminergic synapse Fc epsilon RI signaling pathway 0 -0.617588933 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Fc gamma R-mediated phagocytosis -0.475652174 -0.539525692 -0.437837838 kegg kegg NA NA no up no no no no Dopaminergic synapse Ferroptosis 0.488695652 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Focal adhesion 0 0.442687747 0 kegg kegg NA NA no up no no up up Dopaminergic synapse FoxO signaling pathway 0 -0.539525692 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Fructose and mannose metabolism -0.70173913 -0.418972332 -0.62007722 kegg kegg NA NA no up no no no no Dopaminergic synapse Galactose metabolism -0.78173913 -0.675889328 -0.535649936 kegg kegg NA NA no up no no no no Dopaminergic synapse Gap junction 0.449565217 0.415019763 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Glutamatergic synapse 0.530434783 0 0 kegg kegg NA NA no up no no up up Dopaminergic synapse Glutathione metabolism 0 0.755928854 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Glycerolipid metabolism -0.606956522 0 0 kegg kegg NA NA no up no no no up Dopaminergic synapse "Glycine, serine and threonine metabolism" 0 0.455533597 0 kegg kegg NA NA no up no no up no Dopaminergic synapse Glycolysis / Gluconeogenesis -0.547826087 0 -0.428571429 kegg kegg NA NA no up no no no no Dopaminergic synapse Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.526679842 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.439130435 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Glyoxylate and dicarboxylate metabolism -0.62 -0.581027668 -0.516859717 kegg kegg NA NA no up no no no no Dopaminergic synapse Hematopoietic cell lineage -0.43826087 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Hippo signaling pathway 0 0.483201581 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Hippo signaling pathway - multiple species 0 -0.507905138 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Histidine metabolism -0.617391304 0 -0.657400257 kegg kegg NA NA no up no no no no Dopaminergic synapse IL-17 signaling pathway 0 -0.489130435 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Inositol phosphate metabolism -0.466956522 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse JAK-STAT signaling pathway 0 -0.643280632 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Long-term potentiation 0.572173913 0 0.47001287 kegg kegg NA NA no up no no no up Dopaminergic synapse Lysosome 0 0 -0.523809524 kegg kegg NA NA no up no no no no Dopaminergic synapse MAPK signaling pathway 0 -0.507905138 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Mitophagy - animal 0.626086957 0.527667984 0 kegg kegg NA NA no up no no no no Dopaminergic synapse mRNA surveillance pathway 0.562608696 0.464426877 0.44041184 kegg kegg NA NA no up no no no no Dopaminergic synapse mTOR signaling pathway 0 0.448616601 0 kegg kegg NA NA no up no no no no Dopaminergic synapse N-Glycan biosynthesis 0 0.46541502 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Natural killer cell mediated cytotoxicity 0 -0.564229249 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Necroptosis 0.573043478 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Neuroactive ligand-receptor interaction 0 -0.441699605 -0.423166023 kegg kegg NA NA no up no up up up Dopaminergic synapse Neurotrophin signaling pathway 0 -0.580039526 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Neutrophil extracellular trap formation -0.484347826 0 -0.410810811 kegg kegg NA NA no up no no no no Dopaminergic synapse NF-kappa B signaling pathway -0.433043478 -0.634387352 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Nicotinate and nicotinamide metabolism 0 -0.503952569 -0.47979408 kegg kegg NA NA no up no no no no Dopaminergic synapse NOD-like receptor signaling pathway -0.437391304 -0.811264822 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Non-homologous end-joining -0.535652174 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse One carbon pool by folate 0 0.416996047 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Oocyte meiosis 0.466956522 0 0.451994852 kegg kegg NA NA no up no no no no Dopaminergic synapse Oscillospira 0 -0.425889328 0 LPS-producing kegg Genus NA 0.62 no up no no no no Dopaminergic synapse Osteoclast differentiation -0.45826087 -0.736166008 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Other glycan degradation -0.542608696 -0.480237154 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Oxidative phosphorylation 0.633043478 0.709486166 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Pantothenate and CoA biosynthesis 0 -0.556324111 -0.657400257 kegg kegg NA NA no up no no no dn Dopaminergic synapse Pentose phosphate pathway -0.539130435 -0.436758893 -0.57039897 kegg kegg NA NA no up no no no no Dopaminergic synapse Peroxisome -0.546956522 -0.666007905 -0.571171171 kegg kegg NA NA no up no no no no Dopaminergic synapse Phagosome -0.483478261 -0.522727273 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Phenylalanine metabolism -0.408695652 0 -0.403861004 kegg kegg NA NA no up no no no no Dopaminergic synapse Phosphatidylinositol signaling system 0.434782609 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Platelet activation 0 0.572134387 0 kegg kegg NA NA no up no no no no Dopaminergic synapse PPAR signaling pathway 0 -0.688735178 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Prevotella 0 0 0.411800663 acetate-producing kegg Genus NA 0.287 no up no no no no Dopaminergic synapse Primary bile acid biosynthesis -0.405217391 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Protein export 0.506086957 0.501976285 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Protein processing in endoplasmic reticulum 0 0.500988142 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Pyrimidine metabolism -0.579130435 0.483201581 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Pyruvate metabolism 0 0.441699605 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Rap1 signaling pathway 0 0.415019763 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Ras signaling pathway 0 0.601778656 0.414157014 yes kegg kegg NA NA no up no no up up Dopaminergic synapse Renin-angiotensin system 0 -0.524703557 -0.422136422 kegg kegg NA NA no up no no no no Dopaminergic synapse Retrograde endocannabinoid signaling 0.509565217 0.793478261 0 kegg kegg NA NA no up no no no up Dopaminergic synapse Ribosome 0.537391304 0.610671937 0 kegg kegg NA NA no up no no no no Dopaminergic synapse RIG-I-like receptor signaling pathway 0 -0.647233202 0 kegg kegg NA NA no up no no no no Dopaminergic synapse RNA degradation 0.485217391 0.476284585 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Ruminococcus 0.413913043 0 0 acetate-producing kegg Genus NA 0.335 no up no no no no Dopaminergic synapse Sarcina 0 -0.466781936 0 kegg Genus NA 0.0703 no up no no no no Dopaminergic synapse Serotonergic synapse 0.602608696 0.418972332 0 kegg kegg NA NA no up no no no no Dopaminergic synapse SNARE interactions in vesicular transport -0.446086957 -0.542490119 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Sphingolipid signaling pathway 0 -0.472332016 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Starch and sucrose metabolism -0.535652174 -0.623517787 -0.6 kegg kegg NA NA no up no no no no Dopaminergic synapse Steroid biosynthesis 0.437391304 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Synaptic vesicle cycle 0 0 -0.544916345 kegg kegg NA NA no up no no up up Dopaminergic synapse T cell receptor signaling pathway 0 -0.703557312 0 kegg kegg NA NA no up no no no no Dopaminergic synapse TGF-beta signaling pathway 0.440869565 0.522727273 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Th1 and Th2 cell differentiation 0 -0.740118577 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Th17 cell differentiation 0 -0.793478261 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Thermogenesis 0.635652174 0.711462451 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Thiamine metabolism 0 0.416996047 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Tight junction 0 0.436758893 0 kegg kegg NA NA no up no no no no Dopaminergic synapse TNF signaling pathway 0 -0.606719368 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Toll-like receptor signaling pathway 0 -0.653162055 0 yes kegg kegg NA NA no up no no no no Dopaminergic synapse Tryptophan metabolism -0.645217391 0 0 kegg kegg NA NA no up no no up no Dopaminergic synapse Tyrosine metabolism 0 0.441699605 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Ubiquinone and other terpenoid-quinone biosynthesis -0.483478261 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Ubiquitin mediated proteolysis 0.61826087 0.564229249 0 kegg kegg NA NA no up no no no no Dopaminergic synapse "Valine, leucine and isoleucine degradation" -0.524347826 0 0 kegg kegg NA NA no up no no no no Dopaminergic synapse Vascular smooth muscle contraction 0.77826087 0.833003953 0.766280566 kegg kegg NA NA no up no no no no Dopaminergic synapse Wnt signaling pathway 0.435652174 0.505928854 0 kegg kegg NA NA no up no no no no Dorea Blautia 0 0.505607775 0 acetate-producing Genus Genus 0.00362 1.36E-05 up no dn up dn dn DPA+blood 12-ketoDCA+blood -0.451717371 0 0 serum_ARA serum_bileacids 0.519 0.517 no no no no no no DPA+blood "12,13-EPOME+blood" 0 0 0.415212596 serum_ARA serum_ARA 0.519 0.901 no no no no no no DPA+blood 14:0-LPC+blood 0.446616541 0 0 serum_ARA serum_phospholipids 0.519 0.00689 no no no up up no DPA+blood 14:0/18:2-PC+blood 0.467669173 0 0 serum_ARA serum_phospholipids 0.519 0.102 no no no no up no DPA+blood 14:0+blood 0.62406015 0 0 yes serum_ARA serum_fattyacid 0.519 0.00572 no no no up no dn DPA+blood 16:0-LPC+blood 0.607518797 0 0 serum_ARA serum_phospholipids 0.519 0.00456 no no no up up no DPA+blood 16:0/18:0-PC+blood 0 0 -0.422905983 serum_ARA serum_phospholipids 0.519 0.521 no no no no no no DPA+blood 16:0/18:2-PI+blood 0.455639098 0 0 serum_ARA serum_phospholipids 0.519 0.269 no no no no no no DPA+blood 16:0/20:5-PG+blood -0.466165414 0 0 serum_ARA serum_phospholipids 0.519 0.00656 no no no no up no DPA+blood 16:0+blood 0.446616541 0 0 yes serum_ARA serum_fattyacid 0.519 0.00876 no no no up no no DPA+blood 16:1/16:1-PC+blood 0 0 -0.438632479 serum_ARA serum_phospholipids 0.519 0.0177 no no no no no up DPA+blood 18:0-LPC+blood 0.497744361 0 0 serum_ARA serum_phospholipids 0.519 0.554 no no no no no no DPA+blood 18:0-LPE+blood 0 -0.482843137 0 serum_ARA serum_phospholipids 0.519 0.491 no no no no no no DPA+blood 18:0/18:1-PI+blood 0 0 0.455042735 serum_ARA serum_phospholipids 0.519 0.599 no no no no no no DPA+blood 18:0/22:6-PI+blood 0.542857143 0 0 serum_ARA serum_phospholipids 0.519 0.425 no no no no no no DPA+blood 18:2/16:0-PC+blood 0 0 -0.483076923 serum_ARA serum_phospholipids 0.519 8.67E-05 no no no no up up DPA+blood 18:2n6c+blood 0.606015038 0 -0.467350427 serum_ARA serum_fattyacid 0.519 0.15 no no no no no no DPA+blood 20:2/18:3-PE+blood -0.506766917 0 0 serum_ARA serum_phospholipids 0.519 0.0391 no no no up up no DPA+blood 20:2+blood 0.523308271 0 0 serum_ARA serum_fattyacid 0.519 0.478 no no no no no no DPA+blood 22:6-LPC+blood 0.612030075 0 0 serum_ARA serum_phospholipids 0.519 0.127 no no no no no up DPA+blood Adipocytokine signaling pathway -0.545614035 0 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Adrenergic signaling in cardiomyocytes 0 -0.644117647 0 serum_ARA kegg 0.519 NA no no no no no up DPA+blood Aldosterone synthesis and secretion 0 -0.567647059 0 serum_ARA kegg 0.519 NA no no no no up up DPA+blood Allograft rejection 0 0.747058824 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Amphetamine addiction 0 -0.647058824 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood AMPK signaling pathway 0 -0.520588235 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Amyotrophic lateral sclerosis 0 -0.5 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Apoptosis 0 0.6 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Autoimmune thyroid disease 0 0.747058824 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Biosynthesis of cofactors 0 -0.661764706 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood C-type lectin receptor signaling pathway 0 0.526470588 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Cell adhesion molecules 0 0.764705882 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Cellular senescence 0 0.741176471 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Circadian entrainment 0 -0.597058824 0 serum_ARA kegg 0.519 NA no no no no up up DPA+blood Clostridium 0.500188076 0 0 serum_ARA Genus 0.519 0.925 no no no no no no DPA+blood Cushing syndrome 0 -0.514705882 0 serum_ARA kegg 0.519 NA no no no no no up DPA+blood d18:1-14:1-SM+blood 0 -0.507352941 0 serum_ARA serum_phospholipids 0.519 0.0952 no no no no dn no DPA+blood d18:1-24:1-SM+blood -0.494736842 0 0 serum_ARA serum_phospholipids 0.519 0.0123 no no no no dn dn DPA+blood DHA+blood 0.503759398 0.539215686 0.441367521 serum_ARA serum_ARA 0.519 0.872 no no no no no no DPA+blood Dopaminergic synapse 0 -0.776470588 0 serum_ARA kegg 0.519 NA no no no no up no DPA+blood Endocytosis 0 0.732352941 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Estrogen signaling pathway 0.487719298 0 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Fc epsilon RI signaling pathway 0 0.558823529 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Fc gamma R-mediated phagocytosis 0 0.502941176 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood GABAergic synapse 0 0 -0.453076923 serum_ARA kegg 0.519 NA no no no no up up DPA+blood GCA+stool 0 0.645454545 0 serum_ARA stool_bileacids 0.519 0.0809 no no no no no no DPA+blood Glucagon signaling pathway 0 -0.523529412 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Glutamatergic synapse 0 0 -0.444615385 serum_ARA kegg 0.519 NA no no no no up up DPA+blood "Glycine, serine and threonine metabolism" 0 -0.597058824 0 serum_ARA kegg 0.519 NA no no no no up no DPA+blood Graft-versus-host disease 0 0.747058824 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Human papillomavirus infection 0 0.726470588 0.411538462 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Inflammatory mediator regulation of TRP channels 0.464912281 0 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Insulin signaling pathway 0 -0.520588235 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood JAK-STAT signaling pathway 0 0.5 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Lipid and atherosclerosis 0 0.664705882 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Long-term potentiation 0.568421053 0 0 serum_ARA kegg 0.519 NA no no no no no up DPA+blood Malaria 0 0 -0.431538462 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Measles 0 0 0.411538462 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Mineral absorption 0 -0.570588235 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Morphine addiction 0 -0.561764706 0 serum_ARA kegg 0.519 NA no no no no up up DPA+blood mTOR signaling pathway 0 -0.526470588 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Natural killer cell mediated cytotoxicity 0 0.767647059 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood NOD-like receptor signaling pathway 0 0.626470588 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Osteoclast differentiation 0 0.641176471 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Pancreatic secretion 0 -0.647058824 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood "Parathyroid hormone synthesis, secretion and action" 0 -0.544117647 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Pathogenic Escherichia coli infection 0 0.511764706 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Pathways of neurodegeneration - multiple diseases 0 0 -0.408461538 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Phagosome 0 0.673529412 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Porphyrin and chlorophyll metabolism 0 -0.641176471 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Prolactin signaling pathway 0 0.502941176 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Purine metabolism 0 -0.644117647 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Renin secretion 0 -0.594117647 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Retrograde endocannabinoid signaling 0 -0.505882353 0 serum_ARA kegg 0.519 NA no no no no no up DPA+blood Rheumatoid arthritis 0 0.535294118 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Sphingolipid signaling pathway 0 0.526470588 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Staphylococcus aureus infection 0 0.520588235 0 serum_ARA kegg 0.519 NA no no no up no no DPA+blood Th1 and Th2 cell differentiation 0 0.567647059 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Th17 cell differentiation 0 0.544117647 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Thyroid hormone synthesis 0 -0.605882353 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Toxoplasmosis 0 0.532352941 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Tuberculosis 0 0.520588235 0 serum_ARA kegg 0.519 NA no no no no no dn DPA+blood Type I diabetes mellitus 0 0.747058824 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Vascular smooth muscle contraction 0 -0.602941176 -0.446153846 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Viral carcinogenesis 0 0.764705882 0 serum_ARA kegg 0.519 NA no no no no no no DPA+blood Viral myocarditis 0 0.661764706 0 serum_ARA kegg 0.519 NA no no no no no no Drug metabolism - cytochrome P450 "Alanine, aspartate and glutamate metabolism" 0 -0.717391304 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 alpha-Linolenic acid metabolism 0.433913043 0 0.495752896 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Amino sugar and nucleotide sugar metabolism 0.490434783 0 0.447619048 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Aminoacyl-tRNA biosynthesis 0 0.652173913 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Arachidonic acid metabolism 0.484347826 0 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Arginine and proline metabolism 0 -0.685770751 0 kegg kegg NA NA no no no no up no Drug metabolism - cytochrome P450 Arginine biosynthesis 0 -0.740118577 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Ascorbate and aldarate metabolism 0 0.653162055 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 beta-Alanine metabolism 0 0.668972332 0.535135135 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Butanoate metabolism 0 0.877470356 0.480566281 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Citrate cycle (TCA cycle) 0.489565217 0.91798419 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Cysteine and methionine metabolism 0.590434783 0.812252964 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Fatty acid biosynthesis 0 -0.726284585 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Fatty acid elongation 0 0.589920949 0.566537967 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Folate biosynthesis 0 0.480237154 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Glutathione metabolism 0.474782609 0.558300395 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Glycerophospholipid metabolism -0.434782609 0 0 kegg kegg NA NA no no no no no up Drug metabolism - cytochrome P450 Glycolysis / Gluconeogenesis 0.575652174 0.72826087 0.492406692 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.778656126 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.546442688 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Glycosaminoglycan biosynthesis - keratan sulfate -0.588695652 0 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Glycosphingolipid biosynthesis - ganglio series 0 0.580039526 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Glycosphingolipid biosynthesis - globo and isoglobo series 0.504347826 0 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Glycosphingolipid biosynthesis - lacto and neolacto series -0.671304348 -0.418972332 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Glyoxylate and dicarboxylate metabolism 0 -0.732213439 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Linoleic acid metabolism 0.635652174 0.440711462 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Mannose type O-glycan biosynthesis -0.59826087 0 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Metabolism of xenobiotics by cytochrome P450 0.973913043 0.97826087 0.984298584 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Mucin type O-glycan biosynthesis 0.530434783 0 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 N-Glycan biosynthesis 0 0.783596838 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Nicotinate and nicotinamide metabolism 0 -0.763833992 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Nitrogen metabolism 0 -0.750988142 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 One carbon pool by folate 0 0.76284585 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Other glycan degradation 0 0 0.455341055 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Oxidative phosphorylation 0 0.486166008 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Pantothenate and CoA biosynthesis 0 -0.593873518 0 kegg kegg NA NA no no no no no dn Drug metabolism - cytochrome P450 Pentose and glucuronate interconversions 0.703478261 0.878458498 0.548777349 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Pentose phosphate pathway 0 -0.483201581 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Phenylalanine metabolism 0 0.858695652 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Primary bile acid biosynthesis 0.472173913 0.567193676 0.454054054 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Propanoate metabolism 0.611304348 0.777667984 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Pyrimidine metabolism 0.426956522 0.72826087 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Pyruvate metabolism 0.534782609 0.833003953 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Retinol metabolism 0.637391304 0.658102767 0.501673102 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Sphingolipid metabolism 0 0 0.439382239 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Starch and sucrose metabolism 0 -0.576086957 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Steroid biosynthesis 0 0.678853755 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Steroid hormone biosynthesis 0.617391304 0.727272727 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Sulfur metabolism 0 0.433794466 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Synthesis and degradation of ketone bodies 0 0.687747036 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Taurine and hypotaurine metabolism 0 -0.449604743 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Terpenoid backbone biosynthesis 0 0.437747036 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Thiamine metabolism 0 0.625494071 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Tryptophan metabolism 0 0.779644269 0.426512227 kegg kegg NA NA no no no no up no Drug metabolism - cytochrome P450 Tyrosine metabolism 0.587826087 0.841897233 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Ubiquinone and other terpenoid-quinone biosynthesis 0.406956522 0.78458498 0 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 "Valine, leucine and isoleucine degradation" 0.432173913 0.868577075 0.513770914 kegg kegg NA NA no no no no no no Drug metabolism - cytochrome P450 Various types of N-glycan biosynthesis 0 0.656126482 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes "Alanine, aspartate and glutamate metabolism" 0 -0.814229249 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes alpha-Linolenic acid metabolism 0.705217391 -0.480237154 0.507335907 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Amino sugar and nucleotide sugar metabolism 0.740869565 0 0.407207207 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Aminoacyl-tRNA biosynthesis 0.54 0.450592885 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Arachidonic acid metabolism 0.569565217 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Arginine and proline metabolism 0 -0.696640316 0.414929215 kegg kegg NA NA no no no no up no Drug metabolism - other enzymes Arginine biosynthesis 0 -0.794466403 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Ascorbate and aldarate metabolism 0.433913043 0.553359684 0.564993565 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes beta-Alanine metabolism 0.82173913 0.603754941 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Butanoate metabolism 0.767826087 0.822134387 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Citrate cycle (TCA cycle) 0.711304348 0.856719368 0.42033462 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Cysteine and methionine metabolism 0.434782609 0.757905138 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Drug metabolism - cytochrome P450 0.606956522 0.89229249 0.602574003 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Ether lipid metabolism -0.426086957 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Fatty acid biosynthesis 0 -0.805335968 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Fatty acid degradation 0.496521739 -0.529644269 0.413899614 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Fatty acid elongation 0.708695652 0.586956522 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Folate biosynthesis 0 0.58201581 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Fructose and mannose metabolism 0.686956522 -0.415019763 0.566537967 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Galactose metabolism 0.649565217 -0.46541502 0.601287001 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Glutathione metabolism 0.448695652 0.585968379 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Glycerolipid metabolism 0 -0.555335968 0 kegg kegg NA NA no no no no no up Drug metabolism - other enzymes Glycerophospholipid metabolism 0 -0.513833992 0 kegg kegg NA NA no no no no no up Drug metabolism - other enzymes Glycolysis / Gluconeogenesis 0.835652174 0.792490119 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.840909091 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.633043478 0.53458498 0.436808237 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Glycosaminoglycan biosynthesis - keratan sulfate -0.533913043 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Glycosaminoglycan degradation 0 0 0.547747748 kegg kegg NA NA no no no no no up Drug metabolism - other enzymes Glycosphingolipid biosynthesis - ganglio series 0 0.484189723 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Glycosphingolipid biosynthesis - lacto and neolacto series -0.562608696 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Glyoxylate and dicarboxylate metabolism 0 -0.769762846 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Histidine metabolism 0.599130435 0 0.431660232 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Inositol phosphate metabolism 0 -0.419960474 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Linoleic acid metabolism 0.548695652 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Mannose type O-glycan biosynthesis -0.611304348 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Metabolism of xenobiotics by cytochrome P450 0.736521739 0.908102767 0.574517375 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Mucin type O-glycan biosynthesis 0.48 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes N-Glycan biosynthesis 0 0.72826087 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Nicotinate and nicotinamide metabolism 0 -0.811264822 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Nitrogen metabolism 0 -0.751976285 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes One carbon pool by folate 0 0.599802372 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Other glycan degradation 0 0 0.531788932 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Other types of O-glycan biosynthesis -0.446956522 0 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Oxidative phosphorylation -0.534782609 0.557312253 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Pantothenate and CoA biosynthesis 0 -0.643280632 0 kegg kegg NA NA no no no no no dn Drug metabolism - other enzymes Pentose and glucuronate interconversions 0.605217391 0.850790514 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Phenylalanine metabolism 0.672173913 0.764822134 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Primary bile acid biosynthesis 0.629565217 0.592885375 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Propanoate metabolism 0.57826087 0.720355731 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Pyrimidine metabolism 0.831304348 0.707509881 0.697812098 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Pyruvate metabolism 0.546956522 0.786561265 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Retinol metabolism 0.688695652 0.467391304 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Sphingolipid metabolism 0 0 0.618790219 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Starch and sucrose metabolism 0.477391304 -0.651185771 0.595624196 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Steroid biosynthesis 0 0.559288538 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Steroid hormone biosynthesis 0.604347826 0.595849802 0.442471042 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Sulfur metabolism 0.513043478 0.456521739 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Synthesis and degradation of ketone bodies 0.451304348 0.493083004 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Taurine and hypotaurine metabolism 0 -0.651185771 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Thiamine metabolism 0 0.597826087 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Tryptophan metabolism 0.815652174 0.716403162 0 kegg kegg NA NA no no no no up no Drug metabolism - other enzymes Tyrosine metabolism 0.702608696 0.725296443 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Ubiquinone and other terpenoid-quinone biosynthesis 0.685217391 0.586956522 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes "Valine, leucine and isoleucine degradation" 0.703478261 0.734189723 0 kegg kegg NA NA no no no no no no Drug metabolism - other enzymes Various types of N-glycan biosynthesis 0 0.631422925 0 kegg kegg NA NA no no no no no no ECM-receptor interaction Adrenergic signaling in cardiomyocytes 0 0 0.611840412 kegg kegg NA NA no up up no no up ECM-receptor interaction "Alanine, aspartate and glutamate metabolism" 0 0 -0.404633205 kegg kegg NA NA no up up no no no ECM-receptor interaction Aminoacyl-tRNA biosynthesis 0.485217391 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Antifolate resistance 0 0.532608696 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Apelin signaling pathway 0 0.489130435 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Apoptosis 0 -0.588932806 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Arginine and proline metabolism -0.463478261 0 0 kegg kegg NA NA no up up no up no ECM-receptor interaction Axon guidance 0 0 0.46023166 kegg kegg NA NA no up up no up up ECM-receptor interaction Base excision repair 0.566956522 0.524703557 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Biosynthesis of amino acids 0 0 -0.416473616 kegg kegg NA NA no up up no no no ECM-receptor interaction Biosynthesis of cofactors 0.47826087 0.473320158 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Biosynthesis of unsaturated fatty acids 0.584347826 0.492094862 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Butanoate metabolism 0.471304348 0.568181818 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Calcium signaling pathway 0 0 0.463320463 kegg kegg NA NA no up up no up up ECM-receptor interaction cAMP signaling pathway 0 -0.556324111 0 yes kegg kegg NA NA no up up no up up ECM-receptor interaction Cell cycle 0.527826087 0.522727273 0.404118404 kegg kegg NA NA no up up no no no ECM-receptor interaction Cellular senescence 0 -0.418972332 0 kegg kegg NA NA no up up no no no ECM-receptor interaction cGMP-PKG signaling pathway -0.536521739 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Citrate cycle (TCA cycle) 0.405217391 0.533596838 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Cysteine and methionine metabolism 0.495652174 0.605731225 0 kegg kegg NA NA no up up no no no ECM-receptor interaction DNA replication 0.524347826 0.508893281 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Drug metabolism - cytochrome P450 0 0.476284585 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Drug metabolism - other enzymes 0 0.498023715 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Fanconi anemia pathway 0.58 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Fatty acid degradation 0 0 -0.483140283 kegg kegg NA NA no up up no no no ECM-receptor interaction Fatty acid elongation 0 0.459486166 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Fatty acid metabolism 0 0 -0.472329472 kegg kegg NA NA no up up no no no ECM-receptor interaction Ferroptosis 0 -0.422924901 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Fructose and mannose metabolism 0 0 -0.404375804 kegg kegg NA NA no up up no no no ECM-receptor interaction Glutathione metabolism 0 0.57312253 0 kegg kegg NA NA no up up no no no ECM-receptor interaction "Glycine, serine and threonine metabolism" 0.46 0 0 kegg kegg NA NA no up up no up no ECM-receptor interaction Glycolysis / Gluconeogenesis 0.46 0.444664032 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.586956522 -0.416996047 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.595624196 kegg kegg NA NA no up up no no no ECM-receptor interaction Glycosaminoglycan degradation -0.624347826 -0.438735178 0 kegg kegg NA NA no up up no no up ECM-receptor interaction Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.419130435 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Hippo signaling pathway - multiple species -0.505217391 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Homologous recombination 0.603478261 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Lysosome -0.735652174 0 -0.507850708 kegg kegg NA NA no up up no no no ECM-receptor interaction Metabolism of xenobiotics by cytochrome P450 0 0.421936759 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Mismatch repair 0.533043478 0.595849802 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Mucin type O-glycan biosynthesis 0.435652174 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction N-Glycan biosynthesis 0.612173913 0.488142292 0.482882883 kegg kegg NA NA no up up no no no ECM-receptor interaction NF-kappa B signaling pathway 0 -0.432806324 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Nicotinate and nicotinamide metabolism -0.520869565 -0.463438735 -0.457400257 kegg kegg NA NA no up up no no no ECM-receptor interaction Non-homologous end-joining 0.539130435 0.632411067 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Notch signaling pathway -0.539130435 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Nucleotide excision repair 0.568695652 0.561264822 0 kegg kegg NA NA no up up no no no ECM-receptor interaction One carbon pool by folate 0.560869565 0.5 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Oocyte meiosis 0 0.612648221 0.476962677 kegg kegg NA NA no up up no no no ECM-receptor interaction Osteoclast differentiation -0.571304348 -0.434782609 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Pantothenate and CoA biosynthesis 0 0 -0.478764479 kegg kegg NA NA no up up no no dn ECM-receptor interaction Pentose and glucuronate interconversions 0.45826087 0.442687747 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Pentose phosphate pathway 0 0 -0.500643501 kegg kegg NA NA no up up no no no ECM-receptor interaction Peroxisome 0 0 -0.574517375 kegg kegg NA NA no up up no no no ECM-receptor interaction Phenylalanine metabolism 0 0.425889328 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Phospholipase D signaling pathway 0 -0.522727273 0 kegg kegg NA NA no up up no up up ECM-receptor interaction Platinum drug resistance 0.42 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Primary bile acid biosynthesis 0.506086957 0.507905138 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Propanoate metabolism 0.417391304 0.587944664 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Protein processing in endoplasmic reticulum 0.556521739 0.492094862 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Pyrimidine metabolism 0 0.546442688 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Pyruvate metabolism 0.437391304 0.558300395 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Ras signaling pathway 0 0.585968379 0.453539254 yes kegg kegg NA NA no up up no up up ECM-receptor interaction Retinol metabolism 0 0.555335968 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Ribosome biogenesis in eukaryotes 0.526956522 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction RNA polymerase 0.44173913 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction RNA transport 0.499130435 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Sphingolipid metabolism -0.669565217 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Sphingolipid signaling pathway -0.42173913 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Spliceosome 0.470434783 0 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Starch and sucrose metabolism 0 0 -0.451737452 kegg kegg NA NA no up up no no no ECM-receptor interaction Steroid biosynthesis 0 0.43972332 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Sulfur metabolism 0 0.548418972 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Synthesis and degradation of ketone bodies 0.427826087 0.552371542 0 kegg kegg NA NA no up up no no no ECM-receptor interaction TGF-beta signaling pathway 0 0.490118577 0.50990991 kegg kegg NA NA no up up no no no ECM-receptor interaction Thiamine metabolism 0 0.593873518 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Tryptophan metabolism 0 0.423913043 0 kegg kegg NA NA no up up no up no ECM-receptor interaction Tyrosine metabolism 0.433043478 0.536561265 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Ubiquinone and other terpenoid-quinone biosynthesis 0 0.502964427 0 kegg kegg NA NA no up up no no no ECM-receptor interaction "Valine, leucine and isoleucine degradation" 0.462608696 0.442687747 0 kegg kegg NA NA no up up no no no ECM-receptor interaction Various types of N-glycan biosynthesis 0.487826087 0.566205534 0.403088803 kegg kegg NA NA no up up no no no EGFR tyrosine kinase inhibitor resistance "Alanine, aspartate and glutamate metabolism" 0 -0.590909091 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance alpha-Linolenic acid metabolism 0 -0.792490119 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Arginine and proline metabolism 0 -0.602766798 0 kegg kegg NA NA no no no no up no EGFR tyrosine kinase inhibitor resistance Arginine biosynthesis 0 -0.555335968 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Biosynthesis of amino acids 0 -0.437747036 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Butanoate metabolism 0 0.53458498 0.592277992 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Citrate cycle (TCA cycle) 0 0.510869565 0.514800515 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Cysteine and methionine metabolism 0 0.747035573 0.680566281 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Drug metabolism - cytochrome P450 0 0.542490119 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Drug metabolism - other enzymes 0 0.526679842 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Fatty acid biosynthesis 0 -0.602766798 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Fatty acid degradation 0 -0.480237154 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Fatty acid metabolism 0 -0.477272727 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Fructose and mannose metabolism 0 -0.609683794 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Galactose metabolism 0 -0.662055336 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Glutathione metabolism 0 0.645256917 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Glycerolipid metabolism 0 -0.566205534 0 kegg kegg NA NA no no no no no up EGFR tyrosine kinase inhibitor resistance Glycerophospholipid metabolism 0 -0.456521739 0 kegg kegg NA NA no no no no no up EGFR tyrosine kinase inhibitor resistance Glycolysis / Gluconeogenesis 0 0.639328063 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.66798419 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Glycosaminoglycan degradation -0.428695652 -0.610671937 0 kegg kegg NA NA no no no no no up EGFR tyrosine kinase inhibitor resistance Glyoxylate and dicarboxylate metabolism 0 -0.518774704 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Lysine degradation 0.76173913 0 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Mannose type O-glycan biosynthesis 0.510434783 0 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Metabolism of xenobiotics by cytochrome P450 0 0.4743083 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance N-Glycan biosynthesis 0.415652174 0.587944664 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Nicotinate and nicotinamide metabolism 0 -0.664031621 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Nitrogen metabolism 0 -0.494071146 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Other glycan degradation 0 -0.524703557 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Other types of O-glycan biosynthesis 0.539130435 0 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Oxidative phosphorylation 0 0.666007905 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Pantothenate and CoA biosynthesis -0.435652174 -0.705533597 0 kegg kegg NA NA no no no no no dn EGFR tyrosine kinase inhibitor resistance Parabacteroides 0 0 -0.449707189 kegg Genus NA 4.19E-05 no no no no up up EGFR tyrosine kinase inhibitor resistance Pentose and glucuronate interconversions 0 0.526679842 0.449420849 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Pentose phosphate pathway -0.409565217 -0.489130435 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Propanoate metabolism 0 0.764822134 0.754182754 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Pyruvate metabolism 0 0.788537549 0.659459459 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Selenocompound metabolism 0.496521739 0 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Starch and sucrose metabolism 0 -0.731225296 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Taurine and hypotaurine metabolism 0 -0.418972332 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Thiamine metabolism 0 0.710474308 0 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Tryptophan metabolism 0 0 0.478249678 kegg kegg NA NA no no no no up no EGFR tyrosine kinase inhibitor resistance Ubiquinone and other terpenoid-quinone biosynthesis 0 0 0.441698842 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance "Valine, leucine and isoleucine degradation" 0 0 0.482110682 kegg kegg NA NA no no no no no no EGFR tyrosine kinase inhibitor resistance Various types of N-glycan biosynthesis 0.488695652 0.472332016 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption ABC transporters -0.670434783 0 0 kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Adherens junction 0 0.482213439 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Adrenergic signaling in cardiomyocytes 0.74 0.860671937 0.676705277 kegg kegg NA NA no no no no no up Endocrine and other factor-regulated calcium reabsorption AGE-RAGE signaling pathway in diabetic complications 0 -0.659090909 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption "Alanine, aspartate and glutamate metabolism" -0.604347826 -0.664031621 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Aldosterone synthesis and secretion 0.915652174 0.911067194 0.824453024 kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption alpha-Linolenic acid metabolism -0.626086957 -0.614624506 -0.56962677 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Amino sugar and nucleotide sugar metabolism -0.529565217 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Aminoacyl-tRNA biosynthesis -0.432173913 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption AMPK signaling pathway 0 0.540513834 0.477734878 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Apelin signaling pathway 0 0.609683794 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Apoptosis -0.455652174 -0.593873518 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Arginine and proline metabolism -0.700869565 -0.654150198 0 kegg kegg NA NA no no no no up no Endocrine and other factor-regulated calcium reabsorption Arginine biosynthesis -0.6 -0.601778656 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Ascorbate and aldarate metabolism 0 0 -0.536164736 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Autophagy - animal -0.412173913 -0.586956522 -0.494465894 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption B cell receptor signaling pathway 0 -0.596837945 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Biosynthesis of amino acids -0.473043478 -0.725296443 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Biosynthesis of cofactors 0 0.480237154 0.424453024 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption C-type lectin receptor signaling pathway 0 -0.627470356 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Calcium signaling pathway 0.73826087 0.854743083 0.603346203 kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption cAMP signaling pathway 0.426086957 0 0.492921493 yes kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Carbon metabolism 0 -0.429841897 -0.474388674 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Cardiac muscle contraction 0.530434783 0.791501976 0 kegg kegg NA NA no no no no no up Endocrine and other factor-regulated calcium reabsorption Cell adhesion molecules 0 -0.602766798 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Cell cycle 0 0.47826087 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Cellular senescence 0 -0.469367589 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption cGMP-PKG signaling pathway 0 -0.674901186 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Circadian entrainment 0.693043478 0.691699605 0.852252252 kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Circadian rhythm 0 0.416007905 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Citrate cycle (TCA cycle) 0 0 -0.419305019 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Collinsella 0 -0.44279482 0 kegg Genus NA 0.128 no no no no no no Endocrine and other factor-regulated calcium reabsorption Complement and coagulation cascades 0 -0.633399209 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Coprococcus 0 0 -0.427698051 butyrate-producing kegg Genus NA 0.612 no no no no no no Endocrine and other factor-regulated calcium reabsorption Cortisol synthesis and secretion 0.803478261 0.745059289 0.859202059 kegg kegg NA NA no no no no no up Endocrine and other factor-regulated calcium reabsorption Cushing syndrome 0.82173913 0.744071146 0.694208494 kegg kegg NA NA no no no no no up Endocrine and other factor-regulated calcium reabsorption Dopaminergic synapse 0.63826087 0.825098814 0.722265122 kegg kegg NA NA no no no no up no Endocrine and other factor-regulated calcium reabsorption Drug metabolism - other enzymes 0 0 -0.681081081 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption EGFR tyrosine kinase inhibitor resistance 0 0.538537549 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Endocrine resistance 0.76173913 0.599802372 0.774259974 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Endocytosis 0 -0.56916996 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Estrogen signaling pathway 0 0 0.587129987 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Ether lipid metabolism 0.430434783 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Fatty acid biosynthesis -0.562608696 -0.697628458 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Fatty acid degradation -0.673913043 -0.757905138 -0.565508366 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Fatty acid metabolism -0.670434783 -0.756916996 -0.448133848 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Fc epsilon RI signaling pathway 0 -0.659090909 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Fc gamma R-mediated phagocytosis -0.533913043 -0.75 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Ferroptosis 0.444347826 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption FoxO signaling pathway 0 -0.518774704 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Fructose and mannose metabolism -0.551304348 0 -0.554954955 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption GABAergic synapse -0.430434783 0 0 kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Galactose metabolism -0.559130435 -0.670948617 -0.627541828 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Gap junction 0.809565217 0.531620553 0.716602317 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Glucagon signaling pathway 0.717391304 0.866600791 0.58970399 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Glutamatergic synapse 0.643478261 0 0.614414414 kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Glutathione metabolism 0 0.707509881 0.43037323 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Glycerolipid metabolism -0.50173913 0 -0.401029601 kegg kegg NA NA no no no no no up Endocrine and other factor-regulated calcium reabsorption "Glycine, serine and threonine metabolism" 0 0.522727273 0.424967825 kegg kegg NA NA no no no no up no Endocrine and other factor-regulated calcium reabsorption Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.469367589 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.441698842 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Glycosaminoglycan biosynthesis - keratan sulfate 0.647826087 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Glycosaminoglycan degradation 0 -0.598814229 -0.620592021 kegg kegg NA NA no no no no no up Endocrine and other factor-regulated calcium reabsorption Glyoxylate and dicarboxylate metabolism -0.691304348 -0.64229249 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption GnRH signaling pathway 0.817391304 0.755928854 0.775032175 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption "Growth hormone synthesis, secretion and action" 0 0 0.517889318 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Hedgehog signaling pathway 0.446086957 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Hippo signaling pathway 0.426956522 0.497035573 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Hippo signaling pathway - multiple species -0.453043478 -0.62944664 -0.502702703 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Histidine metabolism -0.45826087 0 -0.511969112 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption IL-17 signaling pathway -0.454782609 -0.648221344 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Inflammatory mediator regulation of TRP channels 0.86 0.884387352 0.837580438 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Insulin secretion 0.828695652 0.821146245 0.820592021 yes kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Insulin signaling pathway 0 0.533596838 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption JAK-STAT signaling pathway -0.416521739 -0.52173913 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Linoleic acid metabolism 0 0.435770751 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Long-term depression 0.899130435 0.562252964 0.818790219 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Longevity regulating pathway 0 0 0.408494208 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Longevity regulating pathway - multiple species 0 -0.517786561 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Lysosome 0 -0.587944664 -0.476447876 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption MAPK signaling pathway 0 -0.546442688 -0.532046332 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Melanogenesis 0.915652174 0.92687747 0.877477477 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Mitophagy - animal 0.567826087 0.747035573 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption mRNA surveillance pathway 0 0.630434783 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption mTOR signaling pathway 0 0.509881423 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Mucin type O-glycan biosynthesis 0 -0.444664032 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption N-Glycan biosynthesis 0 0.542490119 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Natural killer cell mediated cytotoxicity 0 -0.501976285 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Necroptosis 0.559130435 0.416996047 0.412355212 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Neuroactive ligand-receptor interaction 0 -0.690711462 0 kegg kegg NA NA no no no up up up Endocrine and other factor-regulated calcium reabsorption Neurotrophin signaling pathway 0 -0.421936759 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Neutrophil extracellular trap formation -0.416521739 -0.609683794 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption NF-kappa B signaling pathway -0.637391304 -0.559288538 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Nicotinate and nicotinamide metabolism -0.628695652 -0.64229249 -0.455598456 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Nitrogen metabolism -0.444347826 -0.4743083 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption NOD-like receptor signaling pathway -0.720869565 -0.764822134 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Non-alcoholic fatty liver disease 0.530434783 0.7756917 0.486229086 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Olfactory transduction 0 -0.588932806 -0.431917632 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Oscillospira 0 -0.462450593 0 LPS-producing kegg Genus NA 0.62 no no no no no no Endocrine and other factor-regulated calcium reabsorption Osteoclast differentiation -0.671304348 -0.792490119 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Other glycan degradation -0.706086957 0 -0.43037323 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Ovarian steroidogenesis 0.806086957 0.747035573 0.828314028 kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Oxidative phosphorylation 0.497391304 0.781620553 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Pantothenate and CoA biosynthesis -0.503478261 -0.743083004 -0.512998713 kegg kegg NA NA no no no no no dn Endocrine and other factor-regulated calcium reabsorption "Parathyroid hormone synthesis, secretion and action" 0.552173913 0.776679842 0.667181467 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Pentose phosphate pathway 0 -0.664031621 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Peroxisome -0.713043478 -0.795454545 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Phagosome 0 -0.579051383 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption PI3K-Akt signaling pathway -0.420869565 0 0 yes kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Platelet activation 0.430434783 0.4743083 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Porphyrin and chlorophyll metabolism 0 0.434782609 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption PPAR signaling pathway -0.48 -0.753952569 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Prevotella 0 0 0.445587261 acetate-producing kegg Genus NA 0.287 no no no no no no Endocrine and other factor-regulated calcium reabsorption Prolactin signaling pathway 0 -0.57312253 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Proteasome 0 0 -0.531531532 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Protein export 0 0.509881423 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Protein processing in endoplasmic reticulum 0 0.580039526 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Purine metabolism 0 0.545454545 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Pyrimidine metabolism -0.515652174 0 -0.474388674 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Ras signaling pathway 0 0.497035573 0 yes kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption Regulation of lipolysis in adipocytes 0.816521739 0.791501976 0.873616474 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Relaxin signaling pathway 0 0 0.435778636 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Renin secretion 0.789565217 0.855731225 0.911454311 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Renin-angiotensin system 0 -0.678853755 -0.470785071 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Retrograde endocannabinoid signaling 0 0.770750988 0 kegg kegg NA NA no no no no no up Endocrine and other factor-regulated calcium reabsorption Ribosome 0.432173913 0.691699605 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption RIG-I-like receptor signaling pathway -0.51826087 -0.567193676 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption RNA degradation 0 0.616600791 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption RNA polymerase 0 0.53458498 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Serotonergic synapse 0.408695652 0 0.488545689 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption SNARE interactions in vesicular transport -0.690434783 -0.568181818 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Sphingolipid metabolism 0 0 -0.545431145 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Sphingolipid signaling pathway 0 -0.484189723 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Starch and sucrose metabolism -0.665217391 -0.756916996 -0.646846847 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Steroid biosynthesis 0.415652174 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Steroid hormone biosynthesis 0 0 -0.511196911 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Synaptic vesicle cycle 0 -0.633399209 -0.488030888 kegg kegg NA NA no no no no up up Endocrine and other factor-regulated calcium reabsorption T cell receptor signaling pathway 0 -0.499011858 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption TGF-beta signaling pathway 0.413043478 0.497035573 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Th1 and Th2 cell differentiation 0 -0.549407115 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Th17 cell differentiation 0 -0.587944664 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Thermogenesis 0.59826087 0.791501976 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Thiamine metabolism -0.425217391 0 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Thyroid hormone signaling pathway 0 0.597826087 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Thyroid hormone synthesis 0.74 0.869565217 0.758558559 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption TNF signaling pathway 0 -0.447628458 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Toll-like receptor signaling pathway 0 -0.619565217 0 yes kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Type I diabetes mellitus 0 -0.481225296 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Type II diabetes mellitus 0 0 -0.467438867 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Ubiquitin mediated proteolysis 0.617391304 0.782608696 0 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Vascular smooth muscle contraction 0.751304348 0.799407115 0.727927928 kegg kegg NA NA no no no no no no Endocrine and other factor-regulated calcium reabsorption Wnt signaling pathway 0.559130435 0.624505929 0 kegg kegg NA NA no no no no no no Endocrine resistance 2-Oxocarboxylic acid metabolism 0 0 -0.504761905 kegg kegg NA NA no no no no no no Endocrine resistance alpha-Linolenic acid metabolism -0.629565217 0 -0.536422136 kegg kegg NA NA no no no no no no Endocrine resistance Amino sugar and nucleotide sugar metabolism -0.513043478 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Arginine and proline metabolism -0.553913043 0 0 kegg kegg NA NA no no no no up no Endocrine resistance Ascorbate and aldarate metabolism 0 0 -0.487516088 kegg kegg NA NA no no no no no no Endocrine resistance beta-Alanine metabolism -0.457391304 0 -0.425225225 kegg kegg NA NA no no no no no no Endocrine resistance Biosynthesis of amino acids -0.571304348 -0.549407115 0 kegg kegg NA NA no no no no no no Endocrine resistance Butanoate metabolism -0.415652174 0 -0.417503218 kegg kegg NA NA no no no no no no Endocrine resistance Carbon metabolism -0.540869565 -0.668972332 -0.505276705 kegg kegg NA NA no no no no no no Endocrine resistance Citrate cycle (TCA cycle) 0 0 -0.55006435 kegg kegg NA NA no no no no no no Endocrine resistance Clostridium 0 -0.622490144 0 kegg Genus NA 0.925 no no no no no no Endocrine resistance Dorea -0.493043478 0 0 kegg Genus NA 0.00362 no no no up no dn Endocrine resistance Drug metabolism - cytochrome P450 -0.442608696 0 -0.587387387 kegg kegg NA NA no no no no no no Endocrine resistance Drug metabolism - other enzymes -0.634782609 0 -0.636036036 kegg kegg NA NA no no no no no no Endocrine resistance Ether lipid metabolism 0.430434783 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Fatty acid degradation -0.505217391 0 -0.54954955 kegg kegg NA NA no no no no no no Endocrine resistance Fatty acid elongation -0.44173913 -0.505928854 -0.426769627 kegg kegg NA NA no no no no no no Endocrine resistance Fatty acid metabolism -0.565217391 0 -0.461261261 kegg kegg NA NA no no no no no no Endocrine resistance Fructose and mannose metabolism -0.502608696 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Galactose metabolism -0.489565217 0 -0.427541828 kegg kegg NA NA no no no no no no Endocrine resistance Glycerophospholipid metabolism 0 0.460474308 0 kegg kegg NA NA no no no no no up Endocrine resistance "Glycine, serine and threonine metabolism" 0 0.414031621 0.428056628 kegg kegg NA NA no no no no up no Endocrine resistance Glycolysis / Gluconeogenesis -0.475652174 0 -0.411840412 kegg kegg NA NA no no no no no no Endocrine resistance Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.405920206 kegg kegg NA NA no no no no no no Endocrine resistance Glycosaminoglycan biosynthesis - keratan sulfate 0.60173913 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Glycosaminoglycan degradation 0 -0.533596838 -0.541827542 kegg kegg NA NA no no no no no up Endocrine resistance Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.505928854 0 kegg kegg NA NA no no no no no no Endocrine resistance Glyoxylate and dicarboxylate metabolism -0.472173913 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Histidine metabolism -0.406086957 0 -0.414157014 kegg kegg NA NA no no no no no no Endocrine resistance Linoleic acid metabolism -0.451304348 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Lysine degradation 0 0.454545455 0 kegg kegg NA NA no no no no no no Endocrine resistance Metabolism of xenobiotics by cytochrome P450 -0.50173913 0 -0.597940798 kegg kegg NA NA no no no no no no Endocrine resistance Nicotinate and nicotinamide metabolism -0.52 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Odoribacter -0.479268035 -0.61961557 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Endocrine resistance Other glycan degradation -0.5 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Other types of O-glycan biosynthesis 0 0.613636364 0 kegg kegg NA NA no no no no no no Endocrine resistance Pantothenate and CoA biosynthesis 0 0 -0.433719434 kegg kegg NA NA no no no no no dn Endocrine resistance Pentose and glucuronate interconversions 0 0 -0.423938224 kegg kegg NA NA no no no no no no Endocrine resistance Pentose phosphate pathway -0.476521739 -0.488142292 0 kegg kegg NA NA no no no no no no Endocrine resistance Prevotella 0 0.518571986 0.61282385 acetate-producing kegg Genus NA 0.287 no no no no no no Endocrine resistance Primary bile acid biosynthesis 0 -0.423913043 0 kegg kegg NA NA no no no no no no Endocrine resistance Purine metabolism 0 0.455533597 0 kegg kegg NA NA no no no no no no Endocrine resistance Pyrimidine metabolism -0.513913043 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Retinol metabolism 0 0 -0.477220077 kegg kegg NA NA no no no no no no Endocrine resistance Ruminococcus 0.437391304 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Endocrine resistance Sphingolipid metabolism 0 0 -0.435778636 kegg kegg NA NA no no no no no no Endocrine resistance Starch and sucrose metabolism -0.646086957 0 -0.492406692 kegg kegg NA NA no no no no no no Endocrine resistance Steroid biosynthesis 0.44173913 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Steroid hormone biosynthesis -0.406086957 0 -0.417245817 kegg kegg NA NA no no no no no no Endocrine resistance Taurine and hypotaurine metabolism 0 0.517786561 0 kegg kegg NA NA no no no no no no Endocrine resistance Thiamine metabolism -0.445217391 0 0 kegg kegg NA NA no no no no no no Endocrine resistance Tryptophan metabolism -0.431304348 0 -0.486743887 kegg kegg NA NA no no no no up no Endocrine resistance "Valine, leucine and isoleucine degradation" 0 0 -0.405148005 kegg kegg NA NA no no no no no no Endocytosis Amino sugar and nucleotide sugar metabolism 0 0 -0.482882883 kegg kegg NA NA no no no no no no Endocytosis Ascorbate and aldarate metabolism -0.419130435 0 0 kegg kegg NA NA no no no no no no Endocytosis Autophagy - other -0.439130435 0 0 kegg kegg NA NA no no no no no no Endocytosis Bacteroides 0.450434783 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Endocytosis Basal transcription factors -0.672173913 -0.600790514 -0.494465894 kegg kegg NA NA no no no no no no Endocytosis Base excision repair -0.420869565 -0.46541502 -0.508365508 kegg kegg NA NA no no no no no no Endocytosis Biosynthesis of amino acids 0.676521739 0.727272727 0 kegg kegg NA NA no no no no no no Endocytosis Biosynthesis of cofactors 0 -0.781620553 0 kegg kegg NA NA no no no no no no Endocytosis Carbon metabolism 0.48173913 0.524703557 0 kegg kegg NA NA no no no no no no Endocytosis Cell cycle -0.606956522 -0.649209486 0 kegg kegg NA NA no no no no no no Endocytosis cGMP-PKG signaling pathway 0 0.641304348 0.409009009 kegg kegg NA NA no no no no no no Endocytosis Chemokine signaling pathway 0 0.531620553 0.572458172 kegg kegg NA NA no no no no no no Endocytosis DNA replication -0.420869565 -0.462450593 0 kegg kegg NA NA no no no no no no Endocytosis Endocrine resistance 0 -0.616600791 0 kegg kegg NA NA no no no no no no Endocytosis Ether lipid metabolism -0.608695652 -0.732213439 -0.442213642 kegg kegg NA NA no no no no no no Endocytosis Fanconi anemia pathway -0.495652174 -0.557312253 -0.457657658 kegg kegg NA NA no no no no no no Endocytosis FoxO signaling pathway 0 0 -0.458687259 kegg kegg NA NA no no no no no no Endocytosis Glutathione metabolism 0 -0.564229249 0 kegg kegg NA NA no no no no no no Endocytosis Glycerophospholipid metabolism -0.546086957 -0.444664032 0 kegg kegg NA NA no no no no no up Endocytosis "Glycine, serine and threonine metabolism" 0 -0.71541502 0 kegg kegg NA NA no no no no up no Endocytosis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.512173913 0 0 kegg kegg NA NA no no no no no no Endocytosis Glycosaminoglycan degradation 0.411304348 0.601778656 0 kegg kegg NA NA no no no no no up Endocytosis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.767786561 0 kegg kegg NA NA no no no no no no Endocytosis Glyoxylate and dicarboxylate metabolism 0 0.415019763 0 kegg kegg NA NA no no no no no no Endocytosis Homologous recombination 0 -0.497035573 -0.598970399 kegg kegg NA NA no no no no no no Endocytosis Lysosome 0.495652174 0.748023715 0 kegg kegg NA NA no no no no no no Endocytosis Mismatch repair 0 -0.509881423 0 kegg kegg NA NA no no no no no no Endocytosis Mitophagy - animal 0 -0.584980237 0 kegg kegg NA NA no no no no no no Endocytosis mRNA surveillance pathway -0.660869565 -0.524703557 0 kegg kegg NA NA no no no no no no Endocytosis N-Glycan biosynthesis -0.444347826 -0.437747036 0 kegg kegg NA NA no no no no no no Endocytosis Neuroactive ligand-receptor interaction 0 0.726284585 0 kegg kegg NA NA no no no up up up Endocytosis Nicotinate and nicotinamide metabolism 0.428695652 0.486166008 0 kegg kegg NA NA no no no no no no Endocytosis Nitrogen metabolism 0.557391304 0 0 kegg kegg NA NA no no no no no no Endocytosis Nucleotide excision repair -0.445217391 -0.587944664 -0.595366795 kegg kegg NA NA no no no no no no Endocytosis One carbon pool by folate -0.499130435 -0.562252964 0 kegg kegg NA NA no no no no no no Endocytosis Oocyte meiosis -0.486956522 0 0 kegg kegg NA NA no no no no no no Endocytosis Other types of O-glycan biosynthesis -0.616521739 -0.577075099 0 kegg kegg NA NA no no no no no no Endocytosis Oxidative phosphorylation -0.444347826 -0.446640316 0 kegg kegg NA NA no no no no no no Endocytosis p53 signaling pathway -0.545217391 -0.442687747 -0.586100386 kegg kegg NA NA no no no no no no Endocytosis Pantothenate and CoA biosynthesis 0 0.462450593 0 kegg kegg NA NA no no no no no dn Endocytosis Pentose phosphate pathway 0.637391304 0.750988142 0 kegg kegg NA NA no no no no no no Endocytosis Phosphatidylinositol signaling system -0.453913043 0 0 kegg kegg NA NA no no no no no no Endocytosis Platinum drug resistance 0 0 -0.634234234 kegg kegg NA NA no no no no no no Endocytosis Porphyrin and chlorophyll metabolism 0 -0.706521739 0 kegg kegg NA NA no no no no no no Endocytosis PPAR signaling pathway 0.41826087 0.551383399 0.537451737 kegg kegg NA NA no no no no no no Endocytosis Protein export -0.633913043 0 0 kegg kegg NA NA no no no no no no Endocytosis Protein processing in endoplasmic reticulum 0 -0.545454545 0 kegg kegg NA NA no no no no no no Endocytosis Purine metabolism 0 -0.699604743 0 kegg kegg NA NA no no no no no no Endocytosis Pyrimidine metabolism 0 -0.42687747 0 kegg kegg NA NA no no no no no no Endocytosis Pyruvate metabolism 0 -0.442687747 -0.462805663 kegg kegg NA NA no no no no no no Endocytosis Ribosome -0.495652174 0 0 kegg kegg NA NA no no no no no no Endocytosis Ribosome biogenesis in eukaryotes -0.594782609 -0.589920949 0 kegg kegg NA NA no no no no no no Endocytosis RNA degradation -0.615652174 -0.470355731 0 kegg kegg NA NA no no no no no no Endocytosis RNA polymerase -0.595652174 -0.654150198 0 kegg kegg NA NA no no no no no no Endocytosis Ruminococcus -0.413043478 0 0.440926641 acetate-producing kegg Genus NA 0.335 no no no no no no Endocytosis Selenocompound metabolism -0.575652174 -0.493083004 -0.466409266 kegg kegg NA NA no no no no no no Endocytosis Sphingolipid metabolism 0.423478261 0 0 kegg kegg NA NA no no no no no no Endocytosis Sphingolipid signaling pathway 0 0.741106719 0 kegg kegg NA NA no no no no no no Endocytosis Spliceosome -0.44 0 0 kegg kegg NA NA no no no no no no Endocytosis Steroid biosynthesis -0.680869565 0 0 kegg kegg NA NA no no no no no no Endocytosis Steroid hormone biosynthesis 0 -0.423913043 0 kegg kegg NA NA no no no no no no Endocytosis Synthesis and degradation of ketone bodies 0 -0.566205534 -0.428314028 kegg kegg NA NA no no no no no no Endocytosis Taurine and hypotaurine metabolism -0.532173913 0 0 kegg kegg NA NA no no no no no no Endocytosis Terpenoid backbone biosynthesis -0.68 0 0 kegg kegg NA NA no no no no no no Endocytosis Thiamine metabolism 0 -0.531620553 0 kegg kegg NA NA no no no no no no Endocytosis Tyrosine metabolism 0 -0.45256917 0 kegg kegg NA NA no no no no no no Endocytosis Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.414031621 -0.437580438 kegg kegg NA NA no no no no no no Endocytosis Ubiquitin mediated proteolysis 0 -0.663043478 0 kegg kegg NA NA no no no no no no Endocytosis Viral protein interaction with cytokine and cytokine receptor 0.42173913 0 0 kegg kegg NA NA no no no no no no Endometrial cancer 2-Oxocarboxylic acid metabolism -0.530434783 -0.52173913 0 kegg kegg NA NA no no no no no no Endometrial cancer Adherens junction 0 -0.554347826 0 kegg kegg NA NA no no no no no no Endometrial cancer Adipocytokine signaling pathway 0 0.635375494 0 kegg kegg NA NA no no no no no no Endometrial cancer African trypanosomiasis 0.445217391 0 0 kegg kegg NA NA no no no no no no Endometrial cancer AGE-RAGE signaling pathway in diabetic complications 0.537391304 0.65513834 0.61981982 kegg kegg NA NA no no no no no no Endometrial cancer "Alanine, aspartate and glutamate metabolism" 0 0.484189723 0 kegg kegg NA NA no no no no no no Endometrial cancer Aldosterone-regulated sodium reabsorption 0.786956522 0.774703557 0.654568855 kegg kegg NA NA no no no no no no Endometrial cancer Amino sugar and nucleotide sugar metabolism -0.669565217 0 0 kegg kegg NA NA no no no no no no Endometrial cancer Aminoacyl-tRNA biosynthesis 0 -0.482213439 0 kegg kegg NA NA no no no no no no Endometrial cancer Amoebiasis 0 0.571146245 0 kegg kegg NA NA no no no no no no Endometrial cancer Amphetamine addiction 0 -0.427865613 0 kegg kegg NA NA no no no no no no Endometrial cancer Amyotrophic lateral sclerosis 0 -0.447628458 0 kegg kegg NA NA no no no no no no Endometrial cancer Antigen processing and presentation 0 0 -0.411068211 kegg kegg NA NA no no no no no no Endometrial cancer Apelin signaling pathway 0 -0.51284585 0 kegg kegg NA NA no no no no no no Endometrial cancer Apoptosis 0 0.60770751 0 kegg kegg NA NA no no no no no no Endometrial cancer Arachidonic acid metabolism -0.666956522 0 -0.689060489 kegg kegg NA NA no no no no no no Endometrial cancer Arginine and proline metabolism 0 0.516798419 0 kegg kegg NA NA no no no no up no Endometrial cancer Arginine biosynthesis 0 0.453557312 0 kegg kegg NA NA no no no no no no Endometrial cancer Ascorbate and aldarate metabolism -0.427826087 -0.543478261 0 kegg kegg NA NA no no no no no no Endometrial cancer Autophagy - animal 0.58 0.79743083 0.612870013 kegg kegg NA NA no no no no no no Endometrial cancer Autophagy - other 0 0.507905138 0.735907336 kegg kegg NA NA no no no no no no Endometrial cancer Axon guidance 0.591304348 0 0.503732304 kegg kegg NA NA no no no no up up Endometrial cancer B cell receptor signaling pathway 0.547826087 0.70256917 0 kegg kegg NA NA no no no no no no Endometrial cancer Bacterial invasion of epithelial cells 0 -0.545454545 -0.446332046 kegg kegg NA NA no no no no no no Endometrial cancer beta-Alanine metabolism -0.586956522 -0.731225296 -0.451480051 kegg kegg NA NA no no no no no no Endometrial cancer Biosynthesis of cofactors -0.605217391 -0.443675889 0 kegg kegg NA NA no no no no no no Endometrial cancer Biosynthesis of unsaturated fatty acids -0.654782609 -0.719367589 0 kegg kegg NA NA no no no no no no Endometrial cancer Butanoate metabolism -0.58 -0.777667984 -0.414414414 kegg kegg NA NA no no no no no no Endometrial cancer C-type lectin receptor signaling pathway 0.733043478 0.768774704 0.551351351 kegg kegg NA NA no no no no no no Endometrial cancer Calcium signaling pathway 0.453913043 0 0.407979408 kegg kegg NA NA no no no no up up Endometrial cancer cAMP signaling pathway 0.514782609 0.619565217 0 yes kegg kegg NA NA no no no no up up Endometrial cancer Carbohydrate digestion and absorption 0.737391304 0.843873518 0.631660232 kegg kegg NA NA no no no no no no Endometrial cancer Carbon metabolism -0.540869565 -0.428853755 -0.406692407 kegg kegg NA NA no no no no no no Endometrial cancer Cell cycle 0 0 0.431402831 kegg kegg NA NA no no no no no no Endometrial cancer Cellular senescence 0 0.506916996 0 kegg kegg NA NA no no no no no no Endometrial cancer cGMP-PKG signaling pathway 0.453043478 0 0 kegg kegg NA NA no no no no no no Endometrial cancer Chagas disease 0.539130435 0.759881423 0 kegg kegg NA NA no no no no no no Endometrial cancer Chemical carcinogenesis - DNA adducts -0.614782609 0 0 kegg kegg NA NA no no no no no no Endometrial cancer Chemokine signaling pathway 0.492173913 0.469367589 0 kegg kegg NA NA no no no no no no Endometrial cancer Cholinergic synapse 0.499130435 0 0.556756757 kegg kegg NA NA no no no no no no Endometrial cancer Circadian entrainment 0 -0.614624506 -0.428056628 kegg kegg NA NA no no no no up up Endometrial cancer Circadian rhythm 0.493913043 0 0.651737452 kegg kegg NA NA no no no no no no Endometrial cancer Citrate cycle (TCA cycle) -0.612173913 -0.834980237 0 kegg kegg NA NA no no no no no no Endometrial cancer Collecting duct acid secretion 0 -0.509881423 -0.601287001 kegg kegg NA NA no no no no no no Endometrial cancer Colorectal cancer 0.704347826 0.416996047 0.8 kegg kegg NA NA no no no no no no Endometrial cancer Complement and coagulation cascades 0 0 -0.432947233 kegg kegg NA NA no no no no no no Endometrial cancer Cysteine and methionine metabolism -0.466086957 -0.725296443 0 kegg kegg NA NA no no no no no no Endometrial cancer Cytokine-cytokine receptor interaction 0 0 -0.460746461 kegg kegg NA NA no no no no no no Endometrial cancer Cytosolic DNA-sensing pathway 0 0.625494071 0 kegg kegg NA NA no no no no no no Endometrial cancer DNA replication 0 -0.674901186 0 kegg kegg NA NA no no no no no no Endometrial cancer Dopaminergic synapse 0 -0.419960474 0 kegg kegg NA NA no no no no up no Endometrial cancer Drug metabolism - cytochrome P450 -0.582608696 -0.791501976 -0.429343629 kegg kegg NA NA no no no no no no Endometrial cancer Drug metabolism - other enzymes -0.633913043 -0.716403162 0 kegg kegg NA NA no no no no no no Endometrial cancer Epithelial cell signaling in Helicobacter pylori infection 0 0.536561265 0 kegg kegg NA NA no no no no no no Endometrial cancer ErbB signaling pathway 0.866086957 0.848814229 0.873101673 kegg kegg NA NA no no no no no no Endometrial cancer Estrogen signaling pathway -0.474782609 -0.704545455 0 kegg kegg NA NA no no no no no no Endometrial cancer Fatty acid biosynthesis 0 0.471343874 0 kegg kegg NA NA no no no no no no Endometrial cancer Fatty acid elongation -0.614782609 -0.683794466 -0.458172458 kegg kegg NA NA no no no no no no Endometrial cancer Fc epsilon RI signaling pathway 0.756521739 0.690711462 0 kegg kegg NA NA no no no no no no Endometrial cancer Ferroptosis 0 0 -0.501930502 kegg kegg NA NA no no no no no no Endometrial cancer Focal adhesion 0 -0.662055336 0 kegg kegg NA NA no no no no up up Endometrial cancer FoxO signaling pathway 0 0.494071146 0 kegg kegg NA NA no no no no no no Endometrial cancer Fructose and mannose metabolism -0.471304348 0.463438735 0 kegg kegg NA NA no no no no no no Endometrial cancer Gastric acid secretion 0 -0.614624506 -0.404633205 kegg kegg NA NA no no no no no no Endometrial cancer Glutathione metabolism -0.486086957 0 -0.683397683 kegg kegg NA NA no no no no no no Endometrial cancer Glycerolipid metabolism 0 0 0.499356499 kegg kegg NA NA no no no no no up Endometrial cancer Glycerophospholipid metabolism 0 0 0.47001287 kegg kegg NA NA no no no no no up Endometrial cancer "Glycine, serine and threonine metabolism" -0.463478261 0 0 kegg kegg NA NA no no no no up no Endometrial cancer Glycolysis / Gluconeogenesis -0.653043478 -0.716403162 0 kegg kegg NA NA no no no no no no Endometrial cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.447826087 0.787549407 0.428056628 kegg kegg NA NA no no no no no no Endometrial cancer Glycosaminoglycan biosynthesis - keratan sulfate 0.47826087 0 0.428314028 kegg kegg NA NA no no no no no no Endometrial cancer Glycosphingolipid biosynthesis - ganglio series 0 -0.423913043 0 kegg kegg NA NA no no no no no no Endometrial cancer Glycosphingolipid biosynthesis - lacto and neolacto series 0.574782609 0 0.457400257 kegg kegg NA NA no no no no no no Endometrial cancer Glyoxylate and dicarboxylate metabolism 0 0.470355731 0 kegg kegg NA NA no no no no no no Endometrial cancer GnRH secretion 0.869565217 0.860671937 0.74002574 kegg kegg NA NA no no no no up up Endometrial cancer "Growth hormone synthesis, secretion and action" 0.576521739 0.644268775 0.421621622 kegg kegg NA NA no no no no no no Endometrial cancer Hedgehog signaling pathway 0.483478261 0 0.665637066 kegg kegg NA NA no no no no no no Endometrial cancer Hematopoietic cell lineage 0 -0.57312253 0 kegg kegg NA NA no no no no no no Endometrial cancer Hepatitis B 0.674782609 0.749011858 0.77039897 kegg kegg NA NA no no no no no no Endometrial cancer Hepatitis C 0.544347826 0.657114625 0.701415701 kegg kegg NA NA no no no no no no Endometrial cancer Hippo signaling pathway 0 -0.539525692 0 kegg kegg NA NA no no no no no no Endometrial cancer Histidine metabolism -0.440869565 0 0 kegg kegg NA NA no no no no no no Endometrial cancer Human papillomavirus infection 0 0.538537549 0 kegg kegg NA NA no no no no no no Endometrial cancer Huntington disease 0 -0.418972332 0 kegg kegg NA NA no no no no no no Endometrial cancer Inositol phosphate metabolism 0 0 0.425997426 kegg kegg NA NA no no no no no no Endometrial cancer Insulin resistance 0.628695652 0.83201581 0.726640927 kegg kegg NA NA no no no no no no Endometrial cancer Insulin signaling pathway 0 -0.438735178 0 kegg kegg NA NA no no no no no no Endometrial cancer JAK-STAT signaling pathway 0 0.652173913 0 kegg kegg NA NA no no no no no no Endometrial cancer Linoleic acid metabolism 0 -0.416996047 0 kegg kegg NA NA no no no no no no Endometrial cancer Long-term potentiation 0 -0.551383399 0.507078507 kegg kegg NA NA no no no no no up Endometrial cancer Longevity regulating pathway 0.444347826 0 0 kegg kegg NA NA no no no no no no Endometrial cancer Lysine degradation 0 0 0.554954955 kegg kegg NA NA no no no no no no Endometrial cancer Malaria 0 0 -0.416473616 kegg kegg NA NA no no no no no no Endometrial cancer Mannose type O-glycan biosynthesis 0.633913043 0 0.525611326 kegg kegg NA NA no no no no no no Endometrial cancer MAPK signaling pathway 0 0 0.671299871 kegg kegg NA NA no no no no no no Endometrial cancer Metabolism of xenobiotics by cytochrome P450 -0.607826087 -0.838932806 -0.471814672 kegg kegg NA NA no no no no no no Endometrial cancer MicroRNAs in cancer 0.466086957 0.866600791 0.896267696 kegg kegg NA NA no no no no no no Endometrial cancer Mineral absorption 0 0 -0.497039897 kegg kegg NA NA no no no no no no Endometrial cancer Mismatch repair -0.605217391 -0.7243083 0 kegg kegg NA NA no no no no no no Endometrial cancer mRNA surveillance pathway 0.406086957 0 0.574259974 kegg kegg NA NA no no no no no no Endometrial cancer Mucin type O-glycan biosynthesis -0.420869565 0 0 kegg kegg NA NA no no no no no no Endometrial cancer N-Glycan biosynthesis 0 -0.48715415 0 kegg kegg NA NA no no no no no no Endometrial cancer Necroptosis 0 0 -0.475675676 kegg kegg NA NA no no no no no no Endometrial cancer Neurotrophin signaling pathway 0.753913043 0.812252964 0.61029601 kegg kegg NA NA no no no no no no Endometrial cancer Neutrophil extracellular trap formation 0 0 -0.403603604 kegg kegg NA NA no no no no no no Endometrial cancer NF-kappa B signaling pathway 0.493913043 0.755928854 0.599485199 kegg kegg NA NA no no no no no no Endometrial cancer Nicotinate and nicotinamide metabolism 0 0.52173913 0 kegg kegg NA NA no no no no no no Endometrial cancer Nitrogen metabolism 0 0.497035573 0 kegg kegg NA NA no no no no no no Endometrial cancer NOD-like receptor signaling pathway 0 0.648221344 0 kegg kegg NA NA no no no no no no Endometrial cancer Non-homologous end-joining -0.604347826 -0.731225296 0 kegg kegg NA NA no no no no no no Endometrial cancer Notch signaling pathway 0.606956522 0.581027668 0.487516088 kegg kegg NA NA no no no no no no Endometrial cancer Nucleotide excision repair -0.422608696 -0.662055336 0 kegg kegg NA NA no no no no no no Endometrial cancer One carbon pool by folate 0 -0.580039526 0 kegg kegg NA NA no no no no no no Endometrial cancer Oocyte meiosis 0 -0.68083004 0 kegg kegg NA NA no no no no no no Endometrial cancer Osteoclast differentiation 0 0.529644269 0 kegg kegg NA NA no no no no no no Endometrial cancer Other types of O-glycan biosynthesis 0 0 0.51994852 kegg kegg NA NA no no no no no no Endometrial cancer Oxidative phosphorylation 0 -0.41798419 0 kegg kegg NA NA no no no no no no Endometrial cancer Oxytocin signaling pathway 0 -0.444664032 -0.561132561 kegg kegg NA NA no no no no no no Endometrial cancer Pancreatic cancer 0.729565217 0.432806324 0.438095238 kegg kegg NA NA no no no no no no Endometrial cancer Parkinson disease 0 0 -0.403088803 kegg kegg NA NA no no no no no no Endometrial cancer Pathways in cancer 0.574782609 0.684782609 0.628571429 kegg kegg NA NA no no no no no no Endometrial cancer Pathways of neurodegeneration - multiple diseases 0 0 -0.401544402 kegg kegg NA NA no no no no no no Endometrial cancer Pentose and glucuronate interconversions -0.709565217 -0.707509881 0 kegg kegg NA NA no no no no no no Endometrial cancer Phenylalanine metabolism -0.557391304 -0.816205534 0 kegg kegg NA NA no no no no no no Endometrial cancer Phosphatidylinositol signaling system 0.467826087 0 0.6002574 kegg kegg NA NA no no no no no no Endometrial cancer Phospholipase D signaling pathway 0.546086957 0.696640316 0.407979408 kegg kegg NA NA no no no no up up Endometrial cancer Phototransduction 0 -0.792490119 0 kegg kegg NA NA no no no no no no Endometrial cancer Platelet activation 0 -0.545454545 0 kegg kegg NA NA no no no no no no Endometrial cancer Porphyrin and chlorophyll metabolism -0.44173913 0 -0.406177606 kegg kegg NA NA no no no no no no Endometrial cancer PPAR signaling pathway 0 0.556324111 0 kegg kegg NA NA no no no no no no Endometrial cancer Primary bile acid biosynthesis -0.675652174 -0.793478261 -0.428056628 kegg kegg NA NA no no no no no no Endometrial cancer Prion disease 0 -0.490118577 0 kegg kegg NA NA no no no no no no Endometrial cancer Progesterone-mediated oocyte maturation 0 0 0.65971686 kegg kegg NA NA no no no no no no Endometrial cancer Prolactin signaling pathway 0.685217391 0.729249012 0.547232947 kegg kegg NA NA no no no no no no Endometrial cancer Propanoate metabolism -0.514782609 -0.720355731 0 kegg kegg NA NA no no no no no no Endometrial cancer Proteasome 0 -0.694664032 0 kegg kegg NA NA no no no no no no Endometrial cancer Protein digestion and absorption 0 0 0.451480051 yes kegg kegg NA NA no no no no up up Endometrial cancer Protein export 0 -0.495059289 0 kegg kegg NA NA no no no no no no Endometrial cancer Protein processing in endoplasmic reticulum 0 -0.446640316 0 kegg kegg NA NA no no no no no no Endometrial cancer Proximal tubule bicarbonate reclamation -0.473913043 -0.638339921 0 kegg kegg NA NA no no no no no no Endometrial cancer Pyrimidine metabolism -0.556521739 -0.580039526 0 kegg kegg NA NA no no no no no no Endometrial cancer Pyruvate metabolism -0.547826087 -0.717391304 0 kegg kegg NA NA no no no no no no Endometrial cancer Ras signaling pathway 0 -0.449604743 0 yes kegg kegg NA NA no no no no up up Endometrial cancer Regulation of actin cytoskeleton -0.45826087 -0.729249012 -0.545173745 kegg kegg NA NA no no no no no no Endometrial cancer Relaxin signaling pathway 0.497391304 0.684782609 0 kegg kegg NA NA no no no no no no Endometrial cancer Renal cell carcinoma 0.619130435 0 0 kegg kegg NA NA no no no no no no Endometrial cancer Renin secretion 0 -0.58201581 0 kegg kegg NA NA no no no no no no Endometrial cancer Retinol metabolism -0.608695652 -0.705533597 0 kegg kegg NA NA no no no no no no Endometrial cancer Retrograde endocannabinoid signaling 0 -0.523715415 0 kegg kegg NA NA no no no no no up Endometrial cancer RIG-I-like receptor signaling pathway 0.546086957 0.774703557 0.556241956 kegg kegg NA NA no no no no no no Endometrial cancer RNA degradation 0.419130435 0 0.532818533 kegg kegg NA NA no no no no no no Endometrial cancer RNA polymerase 0 -0.424901186 0 kegg kegg NA NA no no no no no no Endometrial cancer Shigellosis 0 0 -0.497554698 kegg kegg NA NA no no no no no no Endometrial cancer Signaling pathways regulating pluripotency of stem cells 0.788695652 0.638339921 0.840926641 kegg kegg NA NA no no no no no no Endometrial cancer SNARE interactions in vesicular transport 0 0.434782609 0 kegg kegg NA NA no no no no no no Endometrial cancer Sphingolipid signaling pathway 0.72 0.622529644 0.496010296 kegg kegg NA NA no no no no no no Endometrial cancer Spinocerebellar ataxia 0.476521739 0 0.467696268 kegg kegg NA NA no no no no no no Endometrial cancer Spliceosome 0 0 0.526640927 kegg kegg NA NA no no no no no no Endometrial cancer Staphylococcus aureus infection 0 0 -0.440669241 kegg kegg NA NA no no no up no no Endometrial cancer Steroid biosynthesis 0 -0.766798419 0 kegg kegg NA NA no no no no no no Endometrial cancer Steroid hormone biosynthesis -0.765217391 -0.730237154 0 kegg kegg NA NA no no no no no no Endometrial cancer Sulfur metabolism -0.473913043 -0.45256917 -0.48030888 kegg kegg NA NA no no no no no no Endometrial cancer Synthesis and degradation of ketone bodies -0.540869565 -0.666007905 0 kegg kegg NA NA no no no no no no Endometrial cancer T cell receptor signaling pathway 0.407826087 0.515810277 0.610810811 kegg kegg NA NA no no no no no no Endometrial cancer Taste transduction 0 -0.597826087 0.448391248 kegg kegg NA NA no no no no no up Endometrial cancer Taurine and hypotaurine metabolism 0 0.598814229 0.536679537 kegg kegg NA NA no no no no no no Endometrial cancer TGF-beta signaling pathway 0 -0.488142292 0 kegg kegg NA NA no no no no no no Endometrial cancer Thermogenesis 0 -0.461462451 0 kegg kegg NA NA no no no no no no Endometrial cancer Thiamine metabolism 0 -0.566205534 0 kegg kegg NA NA no no no no no no Endometrial cancer Tight junction -0.433913043 -0.621541502 -0.743629344 kegg kegg NA NA no no no no no no Endometrial cancer TNF signaling pathway 0.686956522 0.84486166 0.45019305 kegg kegg NA NA no no no no no no Endometrial cancer Toll-like receptor signaling pathway 0.596521739 0.717391304 0 yes kegg kegg NA NA no no no no no no Endometrial cancer Transcriptional misregulation in cancer 0.466956522 0.738142292 0.717117117 kegg kegg NA NA no no no no no no Endometrial cancer Tryptophan metabolism -0.614782609 -0.807312253 0 kegg kegg NA NA no no no no up no Endometrial cancer Type II diabetes mellitus 0.793913043 0.849802372 0.56036036 kegg kegg NA NA no no no no no no Endometrial cancer Tyrosine metabolism -0.742608696 -0.794466403 -0.521492921 kegg kegg NA NA no no no no no no Endometrial cancer Ubiquinone and other terpenoid-quinone biosynthesis -0.647826087 -0.753952569 0 kegg kegg NA NA no no no no no no Endometrial cancer "Valine, leucine and isoleucine degradation" -0.616521739 -0.79743083 0 kegg kegg NA NA no no no no no no Endometrial cancer Various types of N-glycan biosynthesis 0 0 0.405405405 kegg kegg NA NA no no no no no no Endometrial cancer Vascular smooth muscle contraction 0 -0.549407115 0 kegg kegg NA NA no no no no no no Endometrial cancer VEGF signaling pathway 0.826086957 0.807312253 0.706306306 kegg kegg NA NA no no no no no no Endometrial cancer Vibrio cholerae infection 0 -0.542490119 -0.462805663 kegg kegg NA NA no no no no no no Endometrial cancer Viral carcinogenesis 0 0.579051383 0 kegg kegg NA NA no no no no no no Endometrial cancer Viral protein interaction with cytokine and cytokine receptor 0 0 -0.571428571 kegg kegg NA NA no no no no no no Endometrial cancer Vitamin digestion and absorption 0.41826087 0 0 kegg kegg NA NA no no no no no no Endometrial cancer Wnt signaling pathway 0.427826087 0 0.566280566 kegg kegg NA NA no no no no no no Eotaxin 16:0/18:2-PI+blood 0 -0.585714286 0 serum_cytokines serum_phospholipids 0.393 0.269 no no no no no no Eotaxin 16:0/20:4-PI+blood 0 -0.657142857 0 serum_cytokines serum_phospholipids 0.393 0.558 no no no no no no Eotaxin 18:0/18:2-PI+blood 0 -0.557142857 0 serum_cytokines serum_phospholipids 0.393 0.179 no no no no no no Eotaxin 20:2+blood 0 0 -0.654135338 serum_cytokines serum_fattyacid 0.393 0.478 no no no no no no Eotaxin 20:5/18:0-PC+blood 0 0 -0.487218045 serum_cytokines serum_phospholipids 0.393 3.97E-06 no no no no up up Eotaxin 22:6n3+blood 0 0 -0.478195489 serum_cytokines serum_fattyacid 0.393 0.792 no no no no no no Eotaxin "3-(3,4-dihydroxyphenyl)propionic acid+urine" -0.733333333 -0.523529412 0 serum_cytokines urine_cometabolism 0.393 0.0125 no no no up up no Eotaxin ACA+blood 0 0 -0.448275925 serum_cytokines serum_bileacids 0.393 0.338 no no no no no no Eotaxin Adrenergic signaling in cardiomyocytes 0 0 0.539135194 serum_cytokines kegg 0.393 NA no no no no no up Eotaxin Aldosterone synthesis and secretion 0 0 0.4969896 serum_cytokines kegg 0.393 NA no no no no up up Eotaxin Allograft rejection 0 0 -0.478927203 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Amphetamine addiction 0 0 0.46743295 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Anaerostipes 0 0.516224302 0 butyrate-producing serum_cytokines Genus 0.393 0.568 no no no no no no Eotaxin Antigen processing and presentation 0 0 -0.40941434 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Autoimmune thyroid disease 0 0 -0.478927203 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Biosynthesis of amino acids 0 0 -0.570881226 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Butyricimonas -0.555503621 0 0 butyrate-producing serum_cytokines Genus 0.393 0.17 no no no no no no Eotaxin CA+blood 0 0 0.533348639 serum_cytokines serum_bileacids 0.393 0.606 no no no no no no Eotaxin Carbon metabolism 0 0 -0.435686918 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Cell adhesion molecules 0 0 -0.493705528 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Cell cycle 0 0 0.477832512 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Chemical carcinogenesis - receptor activation 0 0 0.461959496 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Choline metabolism in cancer 0 0 0.476190476 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Choline+blood 0 0 -0.461654135 serum_cytokines serum_choline 0.393 0.0395 no no no no up no Eotaxin Cholinergic synapse -0.642857143 0 0.472906404 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Clostridium 0 -0.439532231 0 serum_cytokines Genus 0.393 0.925 no no no no no no Eotaxin Colorectal cancer 0 0 0.410509031 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Coprococcus 0 0 -0.414645044 butyrate-producing serum_cytokines Genus 0.393 0.612 no no no no no no Eotaxin Creatinine+blood 0 0 -0.503759398 serum_cytokines serum_choline 0.393 0.437 no no no no no no Eotaxin Cushing syndrome 0 0 0.424740011 serum_cytokines kegg 0.393 NA no no no no no up Eotaxin Cysteine+blood 0 0 -0.446616541 yes serum_cytokines serum_aminoacids 0.393 1.81E-07 no no no dn up up Eotaxin Cystine+blood 0.733333333 0 0 yes serum_cytokines serum_aminoacids 0.393 0.00028 no no no up up no Eotaxin Dopaminergic synapse 0 0 0.537493158 serum_cytokines kegg 0.393 NA no no no no up no Eotaxin Dorea 0 -0.490418993 0 serum_cytokines Genus 0.393 0.00362 no no no up no dn Eotaxin Endocytosis 0 0 -0.50410509 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin ErbB signaling pathway 0 0 0.40120416 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Fc gamma R-mediated phagocytosis 0 0 -0.403393541 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Fluid shear stress and atherosclerosis 0 -0.529323308 0 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Gastric cancer 0 0 0.407224959 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Glioma 0 0 0.40831965 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Glucagon signaling pathway 0 0 0.503557745 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Graft-versus-host disease 0 0 -0.467980296 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin HDCA+stool 0 0.769230769 0 serum_cytokines stool_bileacids 0.393 0.176 no no no no no no Eotaxin Hematopoietic cell lineage 0.653846154 0 0 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin IL-17 signaling pathway 0 -0.454135338 -0.434044882 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Inflammatory mediator regulation of TRP channels 0 0 0.529830323 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin L-2-Aminobutyric acid+blood 0 0.621428571 0 yes serum_cytokines serum_aminoacids 0.393 0.000328 no no no up up no Eotaxin L-Alanine+blood 0.672727273 0 0 yes serum_cytokines serum_aminoacids 0.393 0.00138 no no no up up no Eotaxin L-Asparagine+blood 0.696969697 0 0 serum_cytokines serum_aminoacids 0.393 0.784 no no no no no no Eotaxin L-Citrulline+blood 0 0.55 0 serum_cytokines serum_aminoacids 0.393 0.534 no no no no no no Eotaxin L-Glutamic acid+blood 0.806060606 0 0 yes serum_cytokines serum_aminoacids 0.393 6.20E-05 no no no up up no Eotaxin L-Glutamine+blood 0.76969697 0 0 serum_cytokines serum_aminoacids 0.393 0.639 no no no no no no Eotaxin L-Lysine+blood 0.648484848 0 0 yes serum_cytokines serum_aminoacids 0.393 0.0107 no no no no up no Eotaxin L-Ornithine+blood 0.733333333 0 0 serum_cytokines serum_aminoacids 0.393 0.175 no no no no no no Eotaxin Leukocyte transendothelial migration 0 -0.586466165 0 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Lipid and atherosclerosis 0 0 -0.417624521 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Long-term potentiation 0 0 0.438970991 serum_cytokines kegg 0.393 NA no no no no no up Eotaxin Lysosome 0 -0.463157895 0 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Measles 0 0.518796992 -0.5030104 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Melanogenesis 0 0 0.409961686 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin mRNA surveillance pathway 0 0 0.463054187 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin MUFA%+blood 0 0 -0.568421053 serum_cytokines serum_fattyacid 0.393 0.00142 no no no up no dn Eotaxin n3+blood 0 0 -0.479699248 serum_cytokines serum_fattyacid 0.393 0.806 no no no no no no Eotaxin Neuroactive ligand-receptor interaction 0 -0.469172932 0 serum_cytokines kegg 0.393 NA no no no up up up Eotaxin Neutrophil extracellular trap formation 0 -0.545864662 -0.483305966 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Non-small cell lung cancer 0 0 0.428571429 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Oxytocin signaling pathway 0 -0.538345865 0 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin P-hydroxyhippuric acid+urine 0 0.526470588 0 serum_cytokines urine_cometabolism 0.393 0.436 no no no no no no Eotaxin p53 signaling pathway 0 0.580451128 0 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Pathogenic Escherichia coli infection 0 0 -0.40831965 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Peroxisome 0 0 -0.470169677 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Phagosome 0 0 -0.666119321 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Phosphatidylinositol signaling system 0 0 0.47454844 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Platelet activation 0 -0.509774436 0 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Platinum drug resistance 0 0 0.438423645 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Primary immunodeficiency 0 0.497744361 0 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Progesterone-mediated oocyte maturation 0 0.448120301 0 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Rap1 signaling pathway 0 -0.535338346 0 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Ras signaling pathway 0 0 0.532019704 yes serum_cytokines kegg 0.393 NA no no no no up up Eotaxin Signaling pathways regulating pluripotency of stem cells 0 0 0.434592228 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Spliceosome 0 0.685714286 0.435139573 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Staphylococcus aureus infection 0 0 -0.483305966 serum_cytokines kegg 0.393 NA no no no up no no Eotaxin Systemic lupus erythematosus 0 -0.448120301 -0.45210728 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin T cell receptor signaling pathway -0.642857143 0 0 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin TUDCA+blood 0 0 0.491042015 yes serum_cytokines serum_bileacids 0.393 0.0282 no no no no no dn Eotaxin Type I diabetes mellitus 0 0 -0.470169677 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin UDCA+blood 0 0.532618622 0 yes serum_cytokines serum_bileacids 0.393 0.0939 no no no no no dn Eotaxin UFA%+blood 0 0 -0.517293233 serum_cytokines serum_fattyacid 0.393 0.0236 no no no no dn no Eotaxin Viral myocarditis 0 0 -0.484400657 serum_cytokines kegg 0.393 NA no no no no no no Eotaxin Viral protein interaction with cytokine and cytokine receptor 0 -0.52481203 0 serum_cytokines kegg 0.393 NA no no no no no no EPA+blood "12,13-EPOME+blood" 0 0 0.519015745 serum_ARA serum_ARA 0.212 0.901 no no no no no no EPA+blood 14:0/18:0-PC+blood 0 -0.830882353 0 serum_ARA serum_phospholipids 0.212 0.00289 no no no up up no EPA+blood 14:0/18:2-PC+blood 0.457142857 0 0 serum_ARA serum_phospholipids 0.212 0.102 no no no no up no EPA+blood 14:0/20:4-PC+blood 0.457142857 0 0 serum_ARA serum_phospholipids 0.212 0.486 no no no no no no EPA+blood 14:0+blood 0.478195489 0 0 yes serum_ARA serum_fattyacid 0.212 0.00572 no no no up no dn EPA+blood 16:0/16:0-PC+blood 0.455639098 0 0 serum_ARA serum_phospholipids 0.212 0.00079 no no no no up up EPA+blood 16:0/16:0-PI+blood 0 -0.774509804 0 serum_ARA serum_phospholipids 0.212 0.358 no no no no no no EPA+blood 16:0/16:1-PC+blood 0 -0.81372549 0 serum_ARA serum_phospholipids 0.212 0.00283 no no no up up no EPA+blood 16:0/16:1-PI+blood 0 -0.68872549 0 serum_ARA serum_phospholipids 0.212 0.262 no no no no no no EPA+blood 16:0/18:0-PC+blood 0.44962406 0 0 serum_ARA serum_phospholipids 0.212 0.521 no no no no no no EPA+blood 16:0/18:1-PE+blood 0 -0.759803922 0 serum_ARA serum_phospholipids 0.212 0.000107 no no no up up no EPA+blood 16:0/18:2-PI+blood 0 -0.723039216 0 serum_ARA serum_phospholipids 0.212 0.269 no no no no no no EPA+blood 16:0/20:4-PC+blood 0 0.607843137 0 serum_ARA serum_phospholipids 0.212 0.0262 no no no no up no EPA+blood 16:0/20:4-PE+blood 0 -0.514705882 0 serum_ARA serum_phospholipids 0.212 0.00139 no no no up up no EPA+blood 16:0/20:5-PC+blood 0.673684211 0.674019608 0.491965812 serum_ARA serum_phospholipids 0.212 0.628 no no no no no no EPA+blood 16:0/22:6-PC+blood 0.593984962 0.725490196 0 serum_ARA serum_phospholipids 0.212 4.53E-05 no no no no up up EPA+blood 16:1/18:1-PG+blood 0 -0.5 0 serum_ARA serum_phospholipids 0.212 3.21E-05 no no no no up up EPA+blood 18:0/18:1-PE+blood 0 -0.558823529 0 serum_ARA serum_phospholipids 0.212 0.00716 no no no up up no EPA+blood 18:0/18:1-PI+blood 0 -0.676470588 0 serum_ARA serum_phospholipids 0.212 0.599 no no no no no no EPA+blood 18:0/20:2-PC+blood 0 -0.519607843 0 serum_ARA serum_phospholipids 0.212 0.733 no no no no no no EPA+blood 18:0/20:3-PC+blood 0 -0.647058824 0 serum_ARA serum_phospholipids 0.212 0.0682 no no no no up no EPA+blood 18:0/20:3-PI+blood 0 -0.629901961 0 serum_ARA serum_phospholipids 0.212 0.377 no no no no no no EPA+blood 18:0/20:4-PC+blood 0 0.759803922 0 serum_ARA serum_phospholipids 0.212 0.454 no no no no no no EPA+blood 18:0/20:5-PC+blood 0 0.857843137 0 serum_ARA serum_phospholipids 0.212 0.17 no no no no no no EPA+blood 18:0/22:6-PA+blood 0.595488722 0 0 serum_ARA serum_phospholipids 0.212 0.22 no no no no no no EPA+blood 18:0/22:6-PC+blood 0.545864662 0.512254902 0.437264957 serum_ARA serum_phospholipids 0.212 0.0775 no no no no no up EPA+blood 18:0/22:6-PI+blood 0 0 0.462564103 serum_ARA serum_phospholipids 0.212 0.425 no no no no no no EPA+blood 18:1/16:0-PE+blood 0 -0.698529412 0 serum_ARA serum_phospholipids 0.212 0.000182 no no no up up no EPA+blood 18:1/16:0-PI+blood 0 -0.723039216 0 serum_ARA serum_phospholipids 0.212 0.793 no no no no no no EPA+blood 18:1/16:1-PE+blood 0 -0.754901961 0 serum_ARA serum_phospholipids 0.212 0.000184 no no no up up no EPA+blood 18:1/18:0-PE+blood 0 -0.735294118 0 serum_ARA serum_phospholipids 0.212 1.39E-06 no no no up up no EPA+blood 18:1/18:1-PC+blood 0 -0.62254902 0 serum_ARA serum_phospholipids 0.212 1.34E-05 no no no no up up EPA+blood 18:1/18:1-PE+blood 0 -0.649509804 0 serum_ARA serum_phospholipids 0.212 1.03E-05 no no no up up no EPA+blood 18:1/18:1-PG+blood 0 -0.495098039 0 serum_ARA serum_phospholipids 0.212 0.00352 no no no no up up EPA+blood 18:1/18:1-PI+blood 0 -0.492647059 0 serum_ARA serum_phospholipids 0.212 0.111 no no no dn no no EPA+blood 18:1/18:2-PE+blood -0.526315789 -0.703431373 0 serum_ARA serum_phospholipids 0.212 0.000293 no no no up up no EPA+blood 18:1/20:3-PC+blood 0 0 -0.511111111 serum_ARA serum_phospholipids 0.212 0.00872 no no no no up up EPA+blood 18:1/20:4-PC+blood 0 0.737745098 0 serum_ARA serum_phospholipids 0.212 0.582 no no no no no no EPA+blood 18:2/18:2-PS+blood 0 -0.654411765 0 serum_ARA serum_phospholipids 0.212 0.00674 no no no up up no EPA+blood 18:2/20:4-PC+blood 0 0.541666667 0 serum_ARA serum_phospholipids 0.212 0.0145 no no no no no up EPA+blood 18:3/16:0-PE+blood 0 -0.495098039 0 serum_ARA serum_phospholipids 0.212 0.00149 no no no up up no EPA+blood 18:3n3+blood 0.45112782 0.659313725 0 serum_ARA serum_fattyacid 0.212 0.291 no no no no no no EPA+blood 20:0/20:4-PE+blood 0 -0.526960784 -0.543931624 serum_ARA serum_phospholipids 0.212 0.00128 no no no up up no EPA+blood 20:1/20:4-PC+blood 0.526315789 0 0 serum_ARA serum_phospholipids 0.212 0.0419 no no no no no up EPA+blood 20:2/18:0-PC+blood 0 -0.625 0 serum_ARA serum_phospholipids 0.212 0.0427 no no no no up no EPA+blood 20:2/18:1-PE+blood 0 -0.656862745 -0.410598291 serum_ARA serum_phospholipids 0.212 0.00208 no no no up up no EPA+blood 20:2/18:3-PE+blood 0 0 -0.417435897 serum_ARA serum_phospholipids 0.212 0.0391 no no no up up no EPA+blood 20:2+blood 0 -0.482843137 0 serum_ARA serum_fattyacid 0.212 0.478 no no no no no no EPA+blood 20:3-LPC+blood 0 -0.610294118 0 serum_ARA serum_phospholipids 0.212 0.0292 no no no no up no EPA+blood 20:3-LPE+blood 0 -0.607843137 0 serum_ARA serum_phospholipids 0.212 0.084 no no no no up no EPA+blood 20:3/16:0-PC+blood 0 0.578431373 0 serum_ARA serum_phospholipids 0.212 0.00405 no no no no up up EPA+blood 20:3/18:0-PC+blood 0.464661654 0 0 serum_ARA serum_phospholipids 0.212 0.296 no no no no no no EPA+blood 20:3n6+blood 0 -0.759803922 0 serum_ARA serum_fattyacid 0.212 0.0884 no no no up no no EPA+blood 20:4-LPC+blood 0 0.821078431 0 serum_ARA serum_phospholipids 0.212 0.949 no no no no no no EPA+blood 20:4n6+blood 0 0.75245098 0 serum_ARA serum_fattyacid 0.212 0.133 no no no no no no EPA+blood 20:5-LPC+blood 0.687218045 0.821078431 0.585641026 serum_ARA serum_phospholipids 0.212 0.558 no no no no no no EPA+blood 20:5/18:0-PC+blood 0.610526316 0.607843137 0 serum_ARA serum_phospholipids 0.212 3.97E-06 no no no no up up EPA+blood 20:5n3+blood 0.72481203 0.703431373 0.683418803 serum_ARA serum_fattyacid 0.212 0.988 no no no no no no EPA+blood 22:0/16:0-PE+blood 0.631578947 0 0 serum_ARA serum_phospholipids 0.212 0.091 no no no no no up EPA+blood 22:2-LPA+blood 0 -0.541666667 0 serum_ARA serum_phospholipids 0.212 0.0443 no no no dn no no EPA+blood 22:6-LPC+blood 0 0.759803922 0 serum_ARA serum_phospholipids 0.212 0.127 no no no no no up EPA+blood 22:6n3+blood 0.505263158 0.620098039 0.485811966 serum_ARA serum_fattyacid 0.212 0.792 no no no no no no EPA+blood 4-hydroxybenzoic acid+stool -0.593406593 0 0 serum_ARA stool_cometabolism 0.212 0.0536 no no no no dn no EPA+blood AA+blood 0 0.615196078 0 serum_ARA serum_ARA 0.212 0.212 no no no no no no EPA+blood ACA+blood 0 0.530691844 0 serum_ARA serum_bileacids 0.212 0.338 no no no no no no EPA+blood Adipocytokine signaling pathway -0.464912281 0 0 serum_ARA kegg 0.212 NA no no no no no no EPA+blood Adlercreutzia 0 0 -0.485966179 serum_ARA Genus 0.212 0.548 no no no no no no EPA+blood Anaerostipes 0 0 -0.464575663 butyrate-producing serum_ARA Genus 0.212 0.568 no no no no no no EPA+blood Axon guidance 0 -0.582352941 0 serum_ARA kegg 0.212 NA no no no no up up EPA+blood Betaine+blood -0.610526316 0 0 serum_ARA serum_choline 0.212 0.857 no no no no no no EPA+blood Cholinergic synapse 0 0.505882353 0 serum_ARA kegg 0.212 NA no no no no no no EPA+blood Collinsella 0 0 -0.467056679 serum_ARA Genus 0.212 0.128 no no no no no no EPA+blood d18:0-18:3-SM+blood 0 0 -0.471452991 serum_ARA serum_phospholipids 0.212 0.0879 no no no no dn no EPA+blood d18:1-18:0-SM+blood 0 0.549019608 0 serum_ARA serum_phospholipids 0.212 0.97 no no no no no no EPA+blood d18:1-22:1-SM+blood 0 0 -0.413333333 serum_ARA serum_phospholipids 0.212 0.222 no no no no no no EPA+blood DCA+blood 0 0 0.535042735 serum_ARA serum_bileacids 0.212 0.122 no no no no no no EPA+blood decanoic acid C10+blood 0 -0.816176471 0 serum_ARA serum_mcfa 0.212 6.64E-11 no no no dn dn no EPA+blood DHA+blood 0.613533835 0.620098039 0.624615385 serum_ARA serum_ARA 0.212 0.872 no no no no no no EPA+blood DL-methionine sulfoxide+blood 0 0 0.464615385 serum_ARA serum_aminoacids 0.212 0.302 no no no no no no EPA+blood Gap junction 0 0 -0.439230769 serum_ARA kegg 0.212 NA no no no no no no EPA+blood Glutamatergic synapse 0 0 -0.484615385 serum_ARA kegg 0.212 NA no no no no up up EPA+blood HDCA+stool 0 0 0.476691729 serum_ARA stool_bileacids 0.212 0.176 no no no no no no EPA+blood Insulin resistance 0 0 0.415384615 serum_ARA kegg 0.212 NA no no no no no no EPA+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.635294118 0 serum_ARA kegg 0.212 NA no no no no no dn EPA+blood Long-term potentiation 0.470175439 0 0 serum_ARA kegg 0.212 NA no no no no no up EPA+blood MAPK signaling pathway 0 0.767647059 0 serum_ARA kegg 0.212 NA no no no no no no EPA+blood PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 0.539230769 serum_ARA kegg 0.212 NA no no no no no no EPA+blood Primary immunodeficiency 0 0.573529412 0 serum_ARA kegg 0.212 NA no no no no no no EPA+blood Progesterone-mediated oocyte maturation 0 0.5 0 serum_ARA kegg 0.212 NA no no no no no no EPA+blood Regulation of lipolysis in adipocytes 0 0 -0.418461538 serum_ARA kegg 0.212 NA no no no no no no EPA+blood Renal cell carcinoma 0 -0.505882353 0 serum_ARA kegg 0.212 NA no no no no no no EPA+blood Renin secretion 0 0 -0.406153846 serum_ARA kegg 0.212 NA no no no no no no EPA+blood Ruminococcus 0 -0.56127451 0 acetate-producing serum_ARA Genus 0.212 0.335 no no no no no no EPA+blood Salivary secretion 0 0 -0.403076923 serum_ARA kegg 0.212 NA no no no no no no EPA+blood TCA+stool 0 -0.645454545 0 serum_ARA stool_bileacids 0.212 0.458 no no no no no no Epithelial cell signaling in Helicobacter pylori infection 2-Oxocarboxylic acid metabolism 0 -0.641304348 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Adipocytokine signaling pathway 0 0.553359684 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Adrenergic signaling in cardiomyocytes 0 -0.541501976 0 kegg kegg NA NA no no no no no up Epithelial cell signaling in Helicobacter pylori infection AGE-RAGE signaling pathway in diabetic complications 0 0.732213439 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection "Alanine, aspartate and glutamate metabolism" 0 0.721343874 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Alcoholism 0 0 0.411325611 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Aldosterone synthesis and secretion 0 -0.687747036 0 kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection Aldosterone-regulated sodium reabsorption 0 0.416007905 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection alpha-Linolenic acid metabolism 0 0.425889328 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Alzheimer disease 0 -0.566205534 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Amino sugar and nucleotide sugar metabolism 0 0 -0.47979408 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Aminoacyl-tRNA biosynthesis 0 -0.624505929 -0.586872587 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Amphetamine addiction -0.532173913 -0.846837945 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection AMPK signaling pathway -0.422608696 -0.423913043 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Amyotrophic lateral sclerosis 0 -0.665019763 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Antifolate resistance 0 -0.610671937 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Apelin signaling pathway 0 -0.590909091 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Apoptosis 0.629565217 0.878458498 0.531274131 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Apoptosis - multiple species -0.426956522 0 -0.724839125 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Arginine and proline metabolism 0 0.786561265 0.501415701 kegg kegg NA NA no no no no up no Epithelial cell signaling in Helicobacter pylori infection Arginine biosynthesis 0 0.781620553 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Ascorbate and aldarate metabolism 0 -0.482213439 -0.411325611 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Autophagy - animal 0 0.636363636 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection B cell receptor signaling pathway 0.56 0.863636364 0.705019305 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Basal transcription factors -0.433043478 -0.749011858 -0.612097812 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Base excision repair -0.48 -0.694664032 -0.73024453 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection beta-Alanine metabolism 0 0 -0.47027027 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Biosynthesis of amino acids 0 0.804347826 0.415444015 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Biosynthesis of cofactors -0.509565217 -0.719367589 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Biosynthesis of unsaturated fatty acids -0.431304348 0 -0.501673102 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Butanoate metabolism 0 -0.694664032 -0.577606178 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection C-type lectin receptor signaling pathway 0.54173913 0.878458498 0.641956242 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection cAMP signaling pathway 0 0.621541502 0.464092664 yes kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection Cardiac muscle contraction 0 -0.542490119 0 kegg kegg NA NA no no no no no up Epithelial cell signaling in Helicobacter pylori infection Cell adhesion molecules 0 0.635375494 0.555727156 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Cell cycle -0.607826087 -0.864624506 -0.607979408 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Cellular senescence 0.520869565 0.714426877 0.647361647 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection cGMP-PKG signaling pathway 0.453043478 0.83201581 0.611325611 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Chemokine signaling pathway 0.733913043 0.804347826 0.736164736 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Cholesterol metabolism 0.446086957 0.559288538 0.491119691 yes kegg kegg NA NA no no no no no up Epithelial cell signaling in Helicobacter pylori infection Circadian entrainment -0.442608696 -0.5256917 0 kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection Circadian rhythm 0 -0.630434783 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Citrate cycle (TCA cycle) -0.46173913 -0.708498024 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Complement and coagulation cascades 0.424347826 0.722332016 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Cushing syndrome -0.466956522 -0.57312253 0 kegg kegg NA NA no no no no no up Epithelial cell signaling in Helicobacter pylori infection Cysteine and methionine metabolism -0.511304348 -0.681818182 -0.631402831 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Cytosolic DNA-sensing pathway 0.595652174 0.571146245 0.728442728 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection DNA replication -0.58173913 -0.87944664 -0.55032175 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Dopaminergic synapse 0 -0.586956522 0 kegg kegg NA NA no no no no up no Epithelial cell signaling in Helicobacter pylori infection Drug metabolism - cytochrome P450 0 -0.786561265 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Drug metabolism - other enzymes 0 -0.645256917 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection ECM-receptor interaction -0.607826087 -0.441699605 0 kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection EGFR tyrosine kinase inhibitor resistance 0 -0.493083004 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Endocrine and other factor-regulated calcium reabsorption 0 -0.584980237 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Endocytosis 0.516521739 0.666007905 0.705534106 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Estrogen signaling pathway -0.520869565 -0.795454545 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Ether lipid metabolism 0 -0.679841897 -0.597940798 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Fanconi anemia pathway -0.544347826 -0.674901186 -0.717374517 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Fat digestion and absorption 0 0.596837945 0 yes kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection Fatty acid biosynthesis 0 0.747035573 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Fatty acid degradation 0 0.470355731 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Fatty acid metabolism 0 0.466403162 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Fc epsilon RI signaling pathway 0 0.856719368 0.420592021 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Fc gamma R-mediated phagocytosis 0.433913043 0.736166008 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Folate biosynthesis 0 -0.518774704 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection FoxO signaling pathway 0 0 -0.581724582 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection GABAergic synapse 0 0.587944664 0 kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection Galactose metabolism 0 0.422924901 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Gastric acid secretion 0 -0.486166008 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Glucagon signaling pathway -0.626956522 -0.833992095 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Glutathione metabolism -0.467826087 -0.643280632 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Glycerophospholipid metabolism 0 0 -0.464864865 kegg kegg NA NA no no no no no up Epithelial cell signaling in Helicobacter pylori infection "Glycine, serine and threonine metabolism" -0.48173913 -0.527667984 0 kegg kegg NA NA no no no no up no Epithelial cell signaling in Helicobacter pylori infection Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.677391304 0.604743083 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.531620553 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Glycosaminoglycan degradation 0.712173913 0.48715415 0 kegg kegg NA NA no no no no no up Epithelial cell signaling in Helicobacter pylori infection Glycosphingolipid biosynthesis - ganglio series 0 -0.608695652 -0.532818533 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.4743083 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Glyoxylate and dicarboxylate metabolism 0 0.803359684 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Hedgehog signaling pathway 0 -0.674901186 -0.410553411 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Hematopoietic cell lineage 0 0 -0.432175032 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection HIF-1 signaling pathway 0 -0.418972332 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Hippo signaling pathway 0 -0.504940711 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Hippo signaling pathway - multiple species 0.520869565 0.531620553 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Homologous recombination -0.435652174 -0.424901186 -0.807464607 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Huntington disease 0 -0.579051383 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection IL-17 signaling pathway 0.744347826 0.836956522 0.700643501 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Inflammatory mediator regulation of TRP channels 0 -0.720355731 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Inositol phosphate metabolism 0 0 -0.585842986 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Insulin resistance 0 0.614624506 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Insulin secretion 0 -0.420948617 0 yes kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection Insulin signaling pathway 0 -0.561264822 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection JAK-STAT signaling pathway 0 0.434782609 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Long-term potentiation 0 -0.517786561 0 kegg kegg NA NA no no no no no up Epithelial cell signaling in Helicobacter pylori infection Lysine degradation 0 -0.427865613 -0.405920206 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Lysosome 0.722608696 0.730237154 0.515830116 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Maturity onset diabetes of the young 0 -0.437747036 0 kegg kegg NA NA no no no no up no Epithelial cell signaling in Helicobacter pylori infection Melanogenesis -0.520869565 -0.65513834 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Metabolism of xenobiotics by cytochrome P450 0 -0.708498024 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Mismatch repair -0.449565217 -0.758893281 -0.553667954 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Morphine addiction 0 -0.456521739 0 kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection mRNA surveillance pathway 0 -0.711462451 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection mTOR signaling pathway 0 -0.484189723 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection N-Glycan biosynthesis -0.61826087 -0.853754941 -0.576576577 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Natural killer cell mediated cytotoxicity 0.514782609 0.690711462 0.663835264 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Neuroactive ligand-receptor interaction 0.413913043 0.640316206 0.53024453 kegg kegg NA NA no no no up up up Epithelial cell signaling in Helicobacter pylori infection Neurotrophin signaling pathway 0.47826087 0.751976285 0.668983269 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Neutrophil extracellular trap formation 0.588695652 0.73715415 0.532046332 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection NF-kappa B signaling pathway 0.482608696 0.710474308 0.455598456 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Nicotinate and nicotinamide metabolism 0.497391304 0.780632411 0.568339768 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Nitrogen metabolism 0.567826087 0.750988142 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection NOD-like receptor signaling pathway 0.550434783 0.824110672 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Non-alcoholic fatty liver disease 0 -0.481225296 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Nucleotide excision repair -0.640869565 -0.865612648 -0.797683398 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Olfactory transduction 0 0.636363636 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection One carbon pool by folate -0.72 -0.910079051 -0.677734878 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Oocyte meiosis -0.507826087 -0.555335968 -0.426254826 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Osteoclast differentiation 0.769565217 0.878458498 0.775289575 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Other types of O-glycan biosynthesis 0 -0.481225296 -0.604118404 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Ovarian steroidogenesis -0.486956522 0 0 kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection Oxidative phosphorylation 0 -0.54743083 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection p53 signaling pathway 0 0 -0.683655084 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Pancreatic secretion 0 -0.513833992 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Pantothenate and CoA biosynthesis 0.487826087 0.640316206 0 kegg kegg NA NA no no no no no dn Epithelial cell signaling in Helicobacter pylori infection Paraprevotella 0 -0.43181515 0 kegg Genus NA 0.118 no no no no no no Epithelial cell signaling in Helicobacter pylori infection Parkinson disease 0 -0.496047431 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Pathways of neurodegeneration - multiple diseases 0 -0.514822134 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Pentose and glucuronate interconversions -0.412173913 -0.785573123 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Pentose phosphate pathway 0.685217391 0.764822134 0.446074646 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Peroxisome 0 0.601778656 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Phagosome 0.436521739 0.707509881 0.624195624 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Phenylalanine metabolism 0 -0.605731225 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Phosphatidylinositol signaling system 0 -0.621541502 -0.471042471 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Phospholipase D signaling pathway 0.475652174 0.602766798 0.410810811 kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection Phototransduction -0.444347826 0 -0.441441441 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Platinum drug resistance 0 0 -0.768082368 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Porphyrin and chlorophyll metabolism -0.416521739 -0.484189723 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection PPAR signaling pathway 0.594782609 0.854743083 0.846074646 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Prevotella -0.504374875 0 0 acetate-producing kegg Genus NA 0.287 no no no no no no Epithelial cell signaling in Helicobacter pylori infection Primary bile acid biosynthesis -0.499130435 0 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Prion disease 0 -0.574110672 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Prolactin signaling pathway 0 0.705533597 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Propanoate metabolism 0 -0.617588933 -0.560617761 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Proteasome 0 -0.497035573 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Protein digestion and absorption 0 0.460474308 0 yes kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection Protein export -0.454782609 -0.657114625 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Protein processing in endoplasmic reticulum -0.564347826 -0.815217391 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Proximal tubule bicarbonate reclamation -0.63826087 -0.840909091 -0.573487773 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Purine metabolism 0 -0.545454545 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Pyrimidine metabolism 0 -0.800395257 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Pyruvate metabolism -0.54173913 -0.745059289 -0.644272844 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Ras signaling pathway 0 -0.637351779 0 yes kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection Relaxin signaling pathway 0 0.603754941 0.504247104 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Renin secretion -0.553913043 -0.691699605 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Renin-angiotensin system 0.453043478 0.764822134 0.4002574 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Retinol metabolism 0 -0.632411067 -0.536164736 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Retrograde endocannabinoid signaling 0 -0.555335968 0 kegg kegg NA NA no no no no no up Epithelial cell signaling in Helicobacter pylori infection Ribosome 0 -0.516798419 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Ribosome biogenesis in eukaryotes -0.591304348 -0.837944664 -0.638095238 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection RIG-I-like receptor signaling pathway 0.586086957 0.733201581 0.542084942 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection RNA degradation 0 -0.785573123 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection RNA polymerase -0.511304348 -0.888339921 -0.582239382 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Selenocompound metabolism 0 -0.441699605 -0.683912484 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Serotonergic synapse 0 0 0.415186615 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Sphingolipid metabolism 0.590434783 0 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Sphingolipid signaling pathway 0 0.657114625 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Spinocerebellar ataxia 0 -0.665019763 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Spliceosome 0 0 -0.492406692 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Starch and sucrose metabolism 0.443478261 0.627470356 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Steroid biosynthesis -0.642608696 -0.696640316 -0.644272844 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Steroid hormone biosynthesis 0 -0.635375494 -0.404633205 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Synaptic vesicle cycle 0.519130435 0.671936759 0 kegg kegg NA NA no no no no up up Epithelial cell signaling in Helicobacter pylori infection Synthesis and degradation of ketone bodies -0.579130435 -0.794466403 -0.622136422 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Taste transduction -0.531304348 -0.756916996 -0.497554698 kegg kegg NA NA no no no no no up Epithelial cell signaling in Helicobacter pylori infection Terpenoid backbone biosynthesis -0.517391304 -0.541501976 -0.47953668 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection TGF-beta signaling pathway 0 -0.566205534 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Thermogenesis 0 -0.606719368 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Thiamine metabolism 0 -0.528656126 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Thyroid hormone synthesis -0.568695652 0 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection TNF signaling pathway 0.497391304 0.761857708 0.716602317 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Toll-like receptor signaling pathway 0.706086957 0.92687747 0.919433719 yes kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Tryptophan metabolism 0 -0.490118577 -0.432175032 kegg kegg NA NA no no no no up no Epithelial cell signaling in Helicobacter pylori infection Type I diabetes mellitus 0 0.572134387 0.53951094 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Type II diabetes mellitus 0 0.418972332 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Tyrosine metabolism -0.505217391 -0.746047431 -0.585842986 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Ubiquinone and other terpenoid-quinone biosynthesis -0.471304348 -0.703557312 -0.643500644 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Ubiquitin mediated proteolysis 0 -0.523715415 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection "Valine, leucine and isoleucine degradation" -0.474782609 -0.739130435 -0.624453024 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Various types of N-glycan biosynthesis 0 -0.726284585 -0.434749035 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Vascular smooth muscle contraction 0 -0.480237154 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Vasopressin-regulated water reabsorption 0 -0.587944664 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection VEGF signaling pathway 0 0.544466403 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Viral protein interaction with cytokine and cytokine receptor 0.446086957 0 0 kegg kegg NA NA no no no no no no Epithelial cell signaling in Helicobacter pylori infection Wnt signaling pathway 0 -0.825098814 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection ABC transporters 0 -0.506916996 0 kegg kegg NA NA no no no no up up Epstein-Barr virus infection Alcoholism 0.536521739 0 0.407722008 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Amino sugar and nucleotide sugar metabolism 0 -0.463438735 -0.416731017 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Aminoacyl-tRNA biosynthesis 0 -0.471343874 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Antifolate resistance -0.659130435 -0.687747036 -0.453539254 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Antigen processing and presentation 0.959130435 0.968379447 0.905019305 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Apoptosis - multiple species 0 -0.540513834 -0.538223938 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Axon guidance 0.496521739 0.501976285 0 kegg kegg NA NA no no no no up up Epstein-Barr virus infection Base excision repair 0 -0.54743083 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Biosynthesis of cofactors 0 -0.455533597 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Cell adhesion molecules 0.471304348 0.517786561 0.723294723 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Cell cycle 0 -0.484189723 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Cellular senescence 0.643478261 0.45256917 0.692149292 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Cholesterol metabolism 0.566086957 0.586956522 0 yes kegg kegg NA NA no no no no no up Epstein-Barr virus infection Clostridium 0 0.415672633 0 kegg Genus NA 0.925 no no no no no no Epstein-Barr virus infection Cocaine addiction 0 -0.421936759 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Cortisol synthesis and secretion -0.433913043 -0.540513834 0 kegg kegg NA NA no no no no no up Epstein-Barr virus infection Cushing syndrome -0.490434783 -0.52173913 0 kegg kegg NA NA no no no no no up Epstein-Barr virus infection Cytosolic DNA-sensing pathway 0 0 0.413899614 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Endocrine resistance -0.549565217 -0.653162055 -0.431660232 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Endocytosis 0.6 0.524703557 0.718661519 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Epithelial cell signaling in Helicobacter pylori infection 0 0 0.52998713 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Ether lipid metabolism -0.435652174 0 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Fanconi anemia pathway 0 -0.631422925 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection FoxO signaling pathway 0 0 -0.431145431 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Fructose and mannose metabolism 0 -0.562252964 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Glycerolipid metabolism 0 -0.596837945 0 kegg kegg NA NA no no no no no up Epstein-Barr virus infection Glycerophospholipid metabolism -0.691304348 -0.65513834 -0.419305019 kegg kegg NA NA no no no no no up Epstein-Barr virus infection "Glycine, serine and threonine metabolism" 0 -0.467391304 0 kegg kegg NA NA no no no no up no Epstein-Barr virus infection Glycosphingolipid biosynthesis - ganglio series 0 0 -0.451480051 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.464347826 -0.561264822 -0.412612613 kegg kegg NA NA no no no no no no Epstein-Barr virus infection GnRH signaling pathway 0 -0.416996047 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection "Growth hormone synthesis, secretion and action" 0 -0.531620553 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Hedgehog signaling pathway -0.474782609 -0.652173913 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Herpes simplex virus 1 infection 0.952173913 0.966403162 0.948005148 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Homologous recombination 0 -0.553359684 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Human cytomegalovirus infection 0.975652174 0.97826087 0.945431145 kegg kegg NA NA no no no no no dn Epstein-Barr virus infection Human papillomavirus infection 0.547826087 0 0.636036036 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Human T-cell leukemia virus 1 infection 0.965217391 0.988142292 0.952638353 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Inositol phosphate metabolism -0.586086957 -0.599802372 -0.595624196 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Insulin secretion -0.460869565 -0.429841897 0 yes kegg kegg NA NA no no no no up up Epstein-Barr virus infection JAK-STAT signaling pathway -0.426956522 0 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Kaposi sarcoma-associated herpesvirus infection 0 0.514822134 0 kegg kegg NA NA no no no no no dn Epstein-Barr virus infection Leukocyte transendothelial migration 0 0.524703557 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Lysine degradation 0 -0.631422925 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Lysosome 0 0.53458498 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Mannose type O-glycan biosynthesis 0 -0.453557312 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection MAPK signaling pathway 0 -0.508893281 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Natural killer cell mediated cytotoxicity 0.643478261 0.516798419 0.751608752 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Neuroactive ligand-receptor interaction 0 0.528656126 0 kegg kegg NA NA no no no up up up Epstein-Barr virus infection Neutrophil extracellular trap formation 0 0 0.428314028 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Nicotine addiction 0 -0.65513834 0 kegg kegg NA NA no no no no up up Epstein-Barr virus infection Notch signaling pathway 0 -0.524703557 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection One carbon pool by folate -0.453043478 -0.493083004 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Other types of O-glycan biosynthesis 0 -0.664031621 -0.467181467 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Ovarian steroidogenesis -0.523478261 0 0 kegg kegg NA NA no no no no up up Epstein-Barr virus infection p53 signaling pathway 0 -0.493083004 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Pathogenic Escherichia coli infection 0 0.476284585 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Pertussis 0 0.425889328 0.419305019 kegg kegg NA NA no no no no no dn Epstein-Barr virus infection Phagosome 0.457391304 0.518774704 0.621879022 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Phenylalanine metabolism 0 0 -0.410810811 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Phosphatidylinositol signaling system 0 0 -0.415186615 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Phototransduction 0 0.467391304 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Platinum drug resistance 0 -0.602766798 -0.537451737 kegg kegg NA NA no no no no no no Epstein-Barr virus infection PPAR signaling pathway 0.54173913 0 0.485456885 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Progesterone-mediated oocyte maturation 0 -0.600790514 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Proteasome 0.415652174 0 0.499099099 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Purine metabolism 0 -0.464426877 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Regulation of actin cytoskeleton 0.422608696 0 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Renin-angiotensin system 0 0.489130435 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Ribosome biogenesis in eukaryotes 0 -0.461462451 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Salmonella infection 0 0.499011858 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Selenocompound metabolism 0 -0.679841897 -0.423423423 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Signaling pathways regulating pluripotency of stem cells 0 -0.437747036 -0.427799228 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Sphingolipid signaling pathway 0 0.496047431 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Spliceosome 0 -0.494071146 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Staphylococcus aureus infection 0 0.48715415 0 kegg kegg NA NA no no no up no no Epstein-Barr virus infection Steroid biosynthesis -0.434782609 0 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Taste transduction 0 -0.475296443 -0.483397683 kegg kegg NA NA no no no no no up Epstein-Barr virus infection Taurine and hypotaurine metabolism -0.457391304 -0.610671937 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Tuberculosis 0 0.460474308 0 kegg kegg NA NA no no no no no dn Epstein-Barr virus infection Type I diabetes mellitus 0.475652174 0.531620553 0.739253539 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Vasopressin-regulated water reabsorption -0.440869565 0 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Viral protein interaction with cytokine and cytokine receptor 0.422608696 0 0 kegg kegg NA NA no no no no no no Epstein-Barr virus infection Vitamin digestion and absorption -0.42 -0.421936759 0 kegg kegg NA NA no no no no no no ErbB signaling pathway ABC transporters 0 0.583003953 0 kegg kegg NA NA no no no no up up ErbB signaling pathway alpha-Linolenic acid metabolism -0.405217391 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Amino sugar and nucleotide sugar metabolism -0.629565217 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Arachidonic acid metabolism -0.563478261 0 -0.682368082 kegg kegg NA NA no no no no no no ErbB signaling pathway Ascorbate and aldarate metabolism -0.437391304 -0.511857708 0 kegg kegg NA NA no no no no no no ErbB signaling pathway beta-Alanine metabolism -0.514782609 -0.605731225 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Biosynthesis of amino acids 0 0 -0.433976834 kegg kegg NA NA no no no no no no ErbB signaling pathway Biosynthesis of cofactors -0.534782609 0 -0.443243243 kegg kegg NA NA no no no no no no ErbB signaling pathway Biosynthesis of unsaturated fatty acids -0.462608696 -0.546442688 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Butanoate metabolism -0.483478261 -0.485177866 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Carbon metabolism -0.520869565 -0.451581028 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Citrate cycle (TCA cycle) -0.506086957 -0.597826087 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Clostridium 0 -0.503289904 0 kegg Genus NA 0.925 no no no no no no ErbB signaling pathway Collinsella 0 0 -0.518591333 kegg Genus NA 0.128 no no no no no no ErbB signaling pathway Cysteine and methionine metabolism -0.455652174 -0.500988142 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Drug metabolism - cytochrome P450 -0.584347826 -0.572134387 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Drug metabolism - other enzymes -0.643478261 -0.60770751 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Endocrine resistance 0.435652174 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Fatty acid elongation -0.527826087 -0.556324111 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Fructose and mannose metabolism -0.426086957 0.508893281 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Galactose metabolism 0 0.42687747 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Gemmiger 0 0.449060556 0 butyrate-producing kegg Genus NA 0.595 no no no no no no ErbB signaling pathway Glutathione metabolism -0.406956522 0 -0.665379665 kegg kegg NA NA no no no no no no ErbB signaling pathway Glycerolipid metabolism 0 0.633399209 0.566795367 kegg kegg NA NA no no no no no up ErbB signaling pathway Glycerophospholipid metabolism 0 0.46541502 0.555727156 kegg kegg NA NA no no no no no up ErbB signaling pathway "Glycine, serine and threonine metabolism" 0 0 -0.408494208 kegg kegg NA NA no no no no up no ErbB signaling pathway Glycolysis / Gluconeogenesis -0.599130435 -0.648221344 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.753952569 0.534877735 kegg kegg NA NA no no no no no no ErbB signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.431145431 kegg kegg NA NA no no no no no no ErbB signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0.51826087 0 0.453539254 kegg kegg NA NA no no no no no no ErbB signaling pathway Glycosphingolipid biosynthesis - globo and isoglobo series -0.477391304 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.553043478 0 0.416731017 kegg kegg NA NA no no no no no no ErbB signaling pathway Histidine metabolism -0.445217391 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Inositol phosphate metabolism 0 0.585968379 0.598198198 kegg kegg NA NA no no no no no no ErbB signaling pathway Lachnospira 0 -0.51791452 0 butyrate-producing kegg Genus NA 0.279 no no no no no no ErbB signaling pathway Linoleic acid metabolism -0.572173913 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Lysine degradation 0.411304348 0.503952569 0.651480051 kegg kegg NA NA no no no no no no ErbB signaling pathway Mannose type O-glycan biosynthesis 0.625217391 0.506916996 0.61029601 kegg kegg NA NA no no no no no no ErbB signaling pathway MAPK signaling pathway 0 0 0.792277992 kegg kegg NA NA no no no no no no ErbB signaling pathway Metabolism of xenobiotics by cytochrome P450 -0.619130435 -0.638339921 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Mismatch repair -0.453913043 -0.416996047 0 kegg kegg NA NA no no no no no no ErbB signaling pathway mRNA surveillance pathway 0.46 0 0.57014157 kegg kegg NA NA no no no no no no ErbB signaling pathway N-Glycan biosynthesis 0 0 0.442213642 kegg kegg NA NA no no no no no no ErbB signaling pathway Non-homologous end-joining -0.472173913 -0.509881423 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Other glycan degradation 0 0.477272727 0.525868726 kegg kegg NA NA no no no no no no ErbB signaling pathway Other types of O-glycan biosynthesis 0 0.501976285 0.620849421 kegg kegg NA NA no no no no no no ErbB signaling pathway Oxidative phosphorylation 0 -0.449604743 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Pentose and glucuronate interconversions -0.689565217 -0.479249012 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Phenylalanine metabolism -0.547826087 -0.540513834 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Platinum drug resistance 0.500869565 0.549407115 0.459202059 kegg kegg NA NA no no no no no no ErbB signaling pathway Porphyrin and chlorophyll metabolism 0 0 -0.47979408 kegg kegg NA NA no no no no no no ErbB signaling pathway Primary bile acid biosynthesis -0.492173913 -0.671936759 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Propanoate metabolism -0.500869565 -0.528656126 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Proteasome 0 -0.704545455 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Protein export 0 -0.496047431 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Purine metabolism 0 0 -0.446074646 kegg kegg NA NA no no no no no no ErbB signaling pathway Pyrimidine metabolism -0.428695652 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Pyruvate metabolism -0.469565217 -0.531620553 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Retinol metabolism -0.517391304 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Ribosome 0 -0.420948617 0 kegg kegg NA NA no no no no no no ErbB signaling pathway RNA degradation 0.483478261 0 0.554697555 kegg kegg NA NA no no no no no no ErbB signaling pathway Ruminococcus 0 -0.547302322 0 kegg Genus NA 0.0679 no no no no no dn ErbB signaling pathway Spliceosome 0 0.520750988 0.548777349 kegg kegg NA NA no no no no no no ErbB signaling pathway Steroid biosynthesis 0 -0.571146245 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Steroid hormone biosynthesis -0.742608696 -0.470355731 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Sulfur metabolism -0.544347826 -0.440711462 -0.53024453 kegg kegg NA NA no no no no no no ErbB signaling pathway Taurine and hypotaurine metabolism 0.512173913 0.734189723 0.418018018 kegg kegg NA NA no no no no no no ErbB signaling pathway Thiamine metabolism -0.433043478 -0.455533597 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Tryptophan metabolism -0.520869565 -0.618577075 0 kegg kegg NA NA no no no no up no ErbB signaling pathway Tyrosine metabolism -0.606086957 -0.509881423 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.536521739 0 0 kegg kegg NA NA no no no no no no ErbB signaling pathway "Valine, leucine and isoleucine degradation" -0.470434783 -0.486166008 0 kegg kegg NA NA no no no no no no ErbB signaling pathway Various types of N-glycan biosynthesis 0 0 0.48957529 kegg kegg NA NA no no no no no no Estrogen signaling pathway 2-Oxocarboxylic acid metabolism 0 0.551383399 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway "Alanine, aspartate and glutamate metabolism" 0 -0.532608696 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Amino sugar and nucleotide sugar metabolism 0 0.420948617 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Aminoacyl-tRNA biosynthesis 0 0.710474308 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway AMPK signaling pathway 0 0 0.465894466 kegg kegg NA NA no no no no no no Estrogen signaling pathway Antifolate resistance 0 0.498023715 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Apelin signaling pathway 0 0.416007905 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Apoptosis 0 -0.697628458 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Arginine and proline metabolism 0 -0.599802372 0 kegg kegg NA NA no no no no up no Estrogen signaling pathway Arginine biosynthesis 0 -0.566205534 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Ascorbate and aldarate metabolism 0 0.606719368 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Autophagy - animal 0 -0.621541502 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Axon guidance 0 -0.486166008 0 kegg kegg NA NA no no no no up up Estrogen signaling pathway B cell receptor signaling pathway -0.609565217 -0.778656126 -0.585585586 kegg kegg NA NA no no no no no no Estrogen signaling pathway Basal transcription factors 0 0.714426877 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Base excision repair 0 0.488142292 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway beta-Alanine metabolism 0 0.555335968 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Biosynthesis of amino acids 0 -0.528656126 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Biosynthesis of cofactors 0 0.608695652 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Biosynthesis of unsaturated fatty acids 0.58173913 0.454545455 0.441956242 kegg kegg NA NA no no no no no no Estrogen signaling pathway Butanoate metabolism 0 0.727272727 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway C-type lectin receptor signaling pathway -0.468695652 -0.818181818 -0.501415701 kegg kegg NA NA no no no no no no Estrogen signaling pathway cAMP signaling pathway 0 -0.627470356 0 yes kegg kegg NA NA no no no no up up Estrogen signaling pathway Cell adhesion molecules 0 -0.527667984 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Cell cycle 0.596521739 0.658102767 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Cellular senescence 0 -0.662055336 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway cGMP-PKG signaling pathway 0 -0.568181818 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Chemokine signaling pathway 0 -0.77173913 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Circadian entrainment 0.613913043 0.590909091 0.635263835 kegg kegg NA NA no no no no up up Estrogen signaling pathway Citrate cycle (TCA cycle) 0.425217391 0.723320158 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Complement and coagulation cascades 0 -0.575098814 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Cysteine and methionine metabolism 0.723478261 0.624505929 0.504504505 kegg kegg NA NA no no no no no no Estrogen signaling pathway Cytosolic DNA-sensing pathway 0 -0.684782609 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway DNA replication 0.496521739 0.752964427 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Dopaminergic synapse 0 0.437747036 0 kegg kegg NA NA no no no no up no Estrogen signaling pathway Drug metabolism - cytochrome P450 0 0.721343874 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Drug metabolism - other enzymes 0 0.611660079 -0.536679537 kegg kegg NA NA no no no no no no Estrogen signaling pathway ECM-receptor interaction 0.562608696 0 0 kegg kegg NA NA no no no no up up Estrogen signaling pathway Endocrine resistance 0 0 0.485199485 kegg kegg NA NA no no no no no no Estrogen signaling pathway Endocytosis 0 -0.538537549 -0.415701416 kegg kegg NA NA no no no no no no Estrogen signaling pathway ErbB signaling pathway 0 -0.4743083 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Ether lipid metabolism 0 0.668972332 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Fanconi anemia pathway 0.54173913 0.613636364 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Fatty acid biosynthesis 0 -0.526679842 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Fc epsilon RI signaling pathway -0.470434783 -0.692687747 -0.55032175 kegg kegg NA NA no no no no no no Estrogen signaling pathway Fc gamma R-mediated phagocytosis 0 -0.457509881 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Focal adhesion 0 0.422924901 0 kegg kegg NA NA no no no no up up Estrogen signaling pathway Fructose and mannose metabolism 0 0 -0.490862291 kegg kegg NA NA no no no no no no Estrogen signaling pathway GABAergic synapse 0 -0.497035573 0 kegg kegg NA NA no no no no up up Estrogen signaling pathway Galactose metabolism 0 0 -0.532046332 kegg kegg NA NA no no no no no no Estrogen signaling pathway Gap junction 0 0 0.596653797 kegg kegg NA NA no no no no no no Estrogen signaling pathway Glutamatergic synapse 0 0 0.448648649 kegg kegg NA NA no no no no up up Estrogen signaling pathway Glycerolipid metabolism 0 0 -0.483397683 kegg kegg NA NA no no no no no up Estrogen signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.530434783 -0.576086957 -0.551093951 kegg kegg NA NA no no no no no no Estrogen signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.422924901 -0.407722008 kegg kegg NA NA no no no no no no Estrogen signaling pathway Glycosaminoglycan degradation -0.516521739 0 -0.673616474 kegg kegg NA NA no no no no no up Estrogen signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 0.623517787 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series -0.517391304 0 -0.459202059 kegg kegg NA NA no no no no no no Estrogen signaling pathway Glyoxylate and dicarboxylate metabolism 0 -0.597826087 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway GnRH signaling pathway 0 0 0.410553411 kegg kegg NA NA no no no no no no Estrogen signaling pathway Hedgehog signaling pathway 0 0.601778656 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Hippo signaling pathway 0 0.471343874 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Hippo signaling pathway - multiple species 0 0 -0.621879022 kegg kegg NA NA no no no no no no Estrogen signaling pathway Homologous recombination 0.575652174 0 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway IL-17 signaling pathway 0 -0.619565217 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Inflammatory mediator regulation of TRP channels 0 0.572134387 0.607207207 kegg kegg NA NA no no no no no no Estrogen signaling pathway Long-term potentiation 0 0.56916996 0 kegg kegg NA NA no no no no no up Estrogen signaling pathway Longevity regulating pathway - multiple species 0.668695652 0 0.574774775 kegg kegg NA NA no no no no no no Estrogen signaling pathway Lysosome -0.584347826 -0.5 -0.488803089 kegg kegg NA NA no no no no no no Estrogen signaling pathway Mannose type O-glycan biosynthesis -0.513913043 0 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway MAPK signaling pathway 0.475652174 0 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Metabolism of xenobiotics by cytochrome P450 0 0.71541502 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Mismatch repair 0.61826087 0.754940711 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway mRNA surveillance pathway 0 0.423913043 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Mucin type O-glycan biosynthesis 0.649565217 0 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway N-Glycan biosynthesis 0 0.666007905 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Natural killer cell mediated cytotoxicity 0 -0.574110672 -0.406435006 kegg kegg NA NA no no no no no no Estrogen signaling pathway Neurotrophin signaling pathway 0 -0.849802372 -0.478249678 kegg kegg NA NA no no no no no no Estrogen signaling pathway Neutrophil extracellular trap formation 0 -0.472332016 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway NF-kappa B signaling pathway 0 -0.696640316 -0.404118404 kegg kegg NA NA no no no no no no Estrogen signaling pathway Nicotinate and nicotinamide metabolism 0 -0.58201581 -0.425225225 kegg kegg NA NA no no no no no no Estrogen signaling pathway Nitrogen metabolism 0 -0.616600791 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway NOD-like receptor signaling pathway 0 -0.652173913 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Non-homologous end-joining 0.413913043 0.511857708 0.41956242 kegg kegg NA NA no no no no no no Estrogen signaling pathway Notch signaling pathway -0.451304348 0 -0.475160875 kegg kegg NA NA no no no no no no Estrogen signaling pathway Nucleotide excision repair 0.545217391 0.829051383 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway One carbon pool by folate 0.630434783 0.852766798 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Oocyte meiosis 0.453913043 0.578063241 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Osteoclast differentiation 0 -0.658102767 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Ovarian steroidogenesis 0.473043478 0 0.493178893 kegg kegg NA NA no no no no up up Estrogen signaling pathway Pentose and glucuronate interconversions 0.571304348 0.751976285 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Pentose phosphate pathway 0 -0.504940711 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Peroxisome 0 -0.415019763 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Phagosome 0 -0.529644269 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Phenylalanine metabolism 0 0.757905138 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Phosphatidylinositol signaling system 0 0.506916996 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Phospholipase D signaling pathway 0 -0.527667984 0 kegg kegg NA NA no no no no up up Estrogen signaling pathway Phototransduction 0 0.495059289 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway PPAR signaling pathway 0 -0.703557312 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Prevotella 0.420878745 0 0 acetate-producing kegg Genus NA 0.287 no no no no no no Estrogen signaling pathway Primary bile acid biosynthesis 0.555652174 0.56027668 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Propanoate metabolism 0.624347826 0.551383399 0.434491634 kegg kegg NA NA no no no no no no Estrogen signaling pathway Proteasome 0 0.5 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Protein export 0 0.485177866 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Protein processing in endoplasmic reticulum 0.455652174 0.651185771 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Purine metabolism 0 0.419960474 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Pyrimidine metabolism 0 0.747035573 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Pyruvate metabolism 0.624347826 0.630434783 0.45045045 kegg kegg NA NA no no no no no no Estrogen signaling pathway Ras signaling pathway 0 0.56027668 0 yes kegg kegg NA NA no no no no up up Estrogen signaling pathway Renin-angiotensin system 0 -0.508893281 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Retinol metabolism 0.597391304 0.736166008 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Ribosome biogenesis in eukaryotes 0 0.71541502 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway RIG-I-like receptor signaling pathway 0 -0.745059289 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway RNA degradation 0 0.52173913 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway RNA polymerase 0 0.721343874 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Selenocompound metabolism 0 0.443675889 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Serotonergic synapse 0.526956522 0 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway SNARE interactions in vesicular transport 0 0 -0.46048906 kegg kegg NA NA no no no no no no Estrogen signaling pathway Sphingolipid metabolism -0.616521739 0 -0.558043758 kegg kegg NA NA no no no no no no Estrogen signaling pathway Sphingolipid signaling pathway 0 -0.621541502 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Starch and sucrose metabolism 0 0 -0.542342342 kegg kegg NA NA no no no no no no Estrogen signaling pathway Steroid biosynthesis 0.559130435 0.842885375 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Steroid hormone biosynthesis 0.448695652 0.834980237 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Synaptic vesicle cycle 0 0 -0.48030888 kegg kegg NA NA no no no no up up Estrogen signaling pathway Synthesis and degradation of ketone bodies 0.631304348 0.796442688 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway T cell receptor signaling pathway 0 -0.501976285 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Taste transduction 0.706086957 0.830039526 0 kegg kegg NA NA no no no no no up Estrogen signaling pathway Terpenoid backbone biosynthesis 0.579130435 0.643280632 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway TGF-beta signaling pathway 0 0.476284585 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Th1 and Th2 cell differentiation -0.656521739 0 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Th17 cell differentiation -0.568695652 0 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Thermogenesis 0 0.427865613 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Thiamine metabolism 0 0.451581028 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway TNF signaling pathway -0.406956522 -0.781620553 -0.475675676 kegg kegg NA NA no no no no no no Estrogen signaling pathway Toll-like receptor signaling pathway 0 -0.835968379 -0.42033462 yes kegg kegg NA NA no no no no no no Estrogen signaling pathway Tryptophan metabolism 0 0.648221344 0 kegg kegg NA NA no no no no up no Estrogen signaling pathway Tyrosine metabolism 0.565217391 0.856719368 0.402831403 kegg kegg NA NA no no no no no no Estrogen signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 0.780632411 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway "Valine, leucine and isoleucine degradation" 0 0.835968379 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Various types of N-glycan biosynthesis 0 0.523715415 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Vascular smooth muscle contraction 0 0.428853755 0.459459459 kegg kegg NA NA no no no no no no Estrogen signaling pathway VEGF signaling pathway 0 -0.648221344 0 kegg kegg NA NA no no no no no no Estrogen signaling pathway Wnt signaling pathway 0 0.575098814 0 kegg kegg NA NA no no no no no no Ethanolamine+blood 12-ketoDCA+blood 0 0.490684079 0 serum_aminoacids serum_bileacids 0.122 0.517 up no no no no no Ethanolamine+blood 13-HODE+blood 0 0.5 0 serum_aminoacids serum_ARA 0.122 0.32 up no no no no no Ethanolamine+blood 14:0/20:4-PC+blood 0 0 -0.424273504 serum_aminoacids serum_phospholipids 0.122 0.486 up no no no no no Ethanolamine+blood 16:0/14:0-PC+blood 0.469172932 0 0 serum_aminoacids serum_phospholipids 0.122 0.0206 up no no no up up Ethanolamine+blood 16:0/16:1-PI+blood -0.488721805 0 0 serum_aminoacids serum_phospholipids 0.122 0.262 up no no no no no Ethanolamine+blood 16:0/18:0-PS+blood 0 -0.571078431 0 serum_aminoacids serum_phospholipids 0.122 0.377 up no no no no no Ethanolamine+blood 16:0/18:1-PC+blood 0.643609023 0 0 serum_aminoacids serum_phospholipids 0.122 6.15E-07 up no no up up up Ethanolamine+blood 16:0/18:2-PC+blood 0.496240602 0 0 serum_aminoacids serum_phospholipids 0.122 3.24E-06 up no no no up up Ethanolamine+blood 16:0/20:4-PC+blood 0.6 0 0 serum_aminoacids serum_phospholipids 0.122 0.0262 up no no no up no Ethanolamine+blood 16:0/20:4-PI+blood -0.502255639 0 0 serum_aminoacids serum_phospholipids 0.122 0.558 up no no no no no Ethanolamine+blood 16:1/16:0-PC+blood 0.448120301 0 0 serum_aminoacids serum_phospholipids 0.122 0.0215 up no no no up up Ethanolamine+blood 18:0-LPA+blood 0.518796992 0 0 serum_aminoacids serum_phospholipids 0.122 0.0725 up no no no dn no Ethanolamine+blood 18:0/16:0-PC+blood 0.603007519 0 0 serum_aminoacids serum_phospholipids 0.122 9.64E-07 up no no up up up Ethanolamine+blood 18:0/18:0-PC+blood 0.458646617 0 0 serum_aminoacids serum_phospholipids 0.122 0.426 up no no no no no Ethanolamine+blood 18:0/18:0-PE+blood 0 -0.487745098 0 serum_aminoacids serum_phospholipids 0.122 0.00896 up no no up up no Ethanolamine+blood 18:0/18:0-PS+blood 0 -0.708333333 0 serum_aminoacids serum_phospholipids 0.122 0.00617 up no no no up no Ethanolamine+blood 18:0/18:1-PE+blood 0 -0.553921569 0 serum_aminoacids serum_phospholipids 0.122 0.00716 up no no up up no Ethanolamine+blood 18:0/18:1-PG+blood 0 -0.568627451 0 serum_aminoacids serum_phospholipids 0.122 0.000842 up no no no up no Ethanolamine+blood 18:0/18:2-PC+blood 0.479699248 0 0 serum_aminoacids serum_phospholipids 0.122 1.74E-06 up no no no up up Ethanolamine+blood 18:0/20:4-PC+blood 0.461654135 0 0 serum_aminoacids serum_phospholipids 0.122 0.454 up no no no no no Ethanolamine+blood 18:0/22:6-PE+blood 0 -0.524509804 0 serum_aminoacids serum_phospholipids 0.122 0.00022 up no no up up no Ethanolamine+blood 18:1/16:0-PC+blood 0.514285714 0 0 serum_aminoacids serum_phospholipids 0.122 2.43E-05 up no no no up up Ethanolamine+blood 18:2-LPA+blood 0 0.634803922 0 serum_aminoacids serum_phospholipids 0.122 0.00684 up no no dn no up Ethanolamine+blood 18:2-LPE+blood 0 0.487745098 0 serum_aminoacids serum_phospholipids 0.122 0.112 up no no no no no Ethanolamine+blood 18:3/18:2-PC+blood 0 0 -0.468717949 serum_aminoacids serum_phospholipids 0.122 0.0394 up no no no no up Ethanolamine+blood 20:1/20:4-PE+blood 0 -0.634803922 0 serum_aminoacids serum_phospholipids 0.122 0.0042 up no no up up no Ethanolamine+blood 20:3/16:0-PC+blood 0.612030075 0 0 serum_aminoacids serum_phospholipids 0.122 0.00405 up no no no up up Ethanolamine+blood 20:4-LPA+blood 0 0.519607843 0 serum_aminoacids serum_phospholipids 0.122 0.398 up no no no no no Ethanolamine+blood 8-HETE+blood 0 0.495098039 0 serum_aminoacids serum_ARA 0.122 0.741 up no no no no no Ethanolamine+blood 9-HODE+blood -0.490225564 0 0 serum_aminoacids serum_ARA 0.122 0.297 up no no no no no Ethanolamine+blood Adherens junction 0.610526316 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Adipocytokine signaling pathway 0 0.652941176 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Alcoholism -0.592982456 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Alistipes 0.510192312 0 0 serum_aminoacids Genus 0.122 0.0114 up no no no up no Ethanolamine+blood Amphetamine addiction 0 -0.591176471 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Anaerostipes 0 0 -0.451553466 butyrate-producing serum_aminoacids Genus 0.122 0.568 up no no no no no Ethanolamine+blood Apelin signaling pathway 0 -0.532352941 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Apoptosis 0.550877193 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Arrhythmogenic right ventricular cardiomyopathy 0.549122807 -0.505882353 0 serum_aminoacids kegg 0.122 NA up no no no up up Ethanolamine+blood Axon guidance -0.535087719 0 0 serum_aminoacids kegg 0.122 NA up no no no up up Ethanolamine+blood B cell receptor signaling pathway 0 0.611764706 0.572307692 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Bacterial invasion of epithelial cells 0.563157895 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Bladder cancer 0 0.514705882 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Breast cancer 0 0 0.414615385 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood C-type lectin receptor signaling pathway 0 0.644117647 0.506923077 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood cAMP signaling pathway 0 0.502941176 0 yes serum_aminoacids kegg 0.122 NA up no no no up up Ethanolamine+blood CDCA+blood 0 -0.522058824 0 serum_aminoacids serum_bileacids 0.122 0.506 up no no no no no Ethanolamine+blood Cell cycle 0 -0.538235294 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Chagas disease 0 0.594117647 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Chemokine signaling pathway 0 0.511764706 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Choline+blood 0 0.485294118 0.532991453 serum_aminoacids serum_choline 0.122 0.0395 up no no no up no Ethanolamine+blood Chronic myeloid leukemia 0 0.623529412 0.573846154 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Clostridium 0 -0.490157248 0 serum_aminoacids Genus 0.122 0.925 up no no no no no Ethanolamine+blood Creatinine+blood 0.460150376 0 0 serum_aminoacids serum_choline 0.122 0.437 up no no no no no Ethanolamine+blood Cytosolic DNA-sensing pathway 0 0.564705882 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood d18:0-18:3-SM+blood 0 0 -0.406495726 serum_aminoacids serum_phospholipids 0.122 0.0879 up no no no dn no Ethanolamine+blood d18:1-14:0-SM+blood 0 -0.632352941 0 serum_aminoacids serum_phospholipids 0.122 0.94 up no no no no no Ethanolamine+blood d18:1-14:1-SM+blood -0.464661654 -0.585784314 -0.445470085 serum_aminoacids serum_phospholipids 0.122 0.0952 up no no no dn no Ethanolamine+blood Dilated cardiomyopathy 0.492982456 0 0 serum_aminoacids kegg 0.122 NA up no no no up up Ethanolamine+blood DL-methionine sulfoxide+blood 0 0 0.42974359 serum_aminoacids serum_aminoacids 0.122 0.302 up no no no no no Ethanolamine+blood Epithelial cell signaling in Helicobacter pylori infection 0 0.644117647 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Estrogen signaling pathway 0 -0.664705882 -0.436923077 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Fluid shear stress and atherosclerosis 0.598245614 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Focal adhesion 0.457894737 -0.520588235 0 serum_aminoacids kegg 0.122 NA up no no no up up Ethanolamine+blood Gastric acid secretion 0.501754386 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Glycolysis / Gluconeogenesis 0 0 -0.455384615 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood HDCA+stool 0.593406593 0 0 serum_aminoacids stool_bileacids 0.122 0.176 up no no no no no Ethanolamine+blood Hematopoietic cell lineage 0 0 -0.513076923 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Hepatitis B 0 0.564705882 0.493076923 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Hepatocellular carcinoma 0.614035088 -0.508823529 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood HIF-1 signaling pathway 0 -0.502941176 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Hippo signaling pathway 0.577192982 -0.585294118 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Hypertrophic cardiomyopathy 0.524561404 0 0 serum_aminoacids kegg 0.122 NA up no no no up up Ethanolamine+blood Inflammatory mediator regulation of TRP channels 0 -0.511764706 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Influenza A 0.626315789 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Insulin resistance 0 0.661764706 0.539230769 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Insulin signaling pathway 0 -0.567647059 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Leukocyte transendothelial migration 0.464912281 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Lipid and atherosclerosis 0 0.564705882 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Long-term potentiation 0 -0.558823529 0 serum_aminoacids kegg 0.122 NA up no no no no up Ethanolamine+blood mRNA surveillance pathway 0 -0.502941176 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Neurotrophin signaling pathway 0 0.638235294 0.559230769 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood NF-kappa B signaling pathway 0 0.605882353 0.437692308 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood NOD-like receptor signaling pathway 0 0.555882353 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Odoribacter 0 0 0.406360337 butyrate-producing serum_aminoacids Genus 0.122 0.798 up no no no no no Ethanolamine+blood Oocyte meiosis 0 -0.641176471 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Osteoclast differentiation 0 0.523529412 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Oxytocin signaling pathway 0.480701754 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood p53 signaling pathway -0.540350877 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Parabacteroides 0.621052632 0 0.415113701 serum_aminoacids Genus 0.122 4.19E-05 up no no no up up Ethanolamine+blood Pathogenic Escherichia coli infection 0.514035088 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Pathways in cancer -0.5 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.685294118 0.633846154 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Platelet activation 0.478947368 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Platinum drug resistance -0.477192982 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood PPAR signaling pathway 0 0.588235294 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Prevotella 0.460374502 0 0 serum_aminoacids Genus 0.122 0.367 up no no no no no Ethanolamine+blood Prevotella 0 0 0.41911497 acetate-producing serum_aminoacids Genus 0.122 0.287 up no no no no no Ethanolamine+blood Primary immunodeficiency 0 0 -0.466153846 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Prolactin signaling pathway 0 0.544117647 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Prostate cancer 0 0.614705882 0.580769231 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Protein processing in endoplasmic reticulum 0 -0.620588235 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Proteoglycans in cancer 0 -0.517647059 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Pyramidobacter 0 0 0.48342045 serum_aminoacids Genus 0.122 0.45 up no no no no no Ethanolamine+blood Rap1 signaling pathway 0.540350877 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Ras signaling pathway 0 -0.626470588 0 yes serum_aminoacids kegg 0.122 NA up no no no up up Ethanolamine+blood Regulation of actin cytoskeleton 0 -0.555882353 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Relaxin signaling pathway 0 0.561764706 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Renin secretion 0 -0.532352941 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood RIG-I-like receptor signaling pathway 0 0.591176471 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Small cell lung cancer 0 0.623529412 0.445384615 serum_aminoacids kegg 0.122 NA up no no no no up Ethanolamine+blood Spinocerebellar ataxia -0.477192982 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Spliceosome -0.487719298 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood T cell receptor signaling pathway 0 0.561764706 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood TCA+stool 0 0 -0.503759398 serum_aminoacids stool_bileacids 0.122 0.458 up no no no no no Ethanolamine+blood Th17 cell differentiation 0 0.502941176 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Thyroid hormone signaling pathway 0.557894737 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Tight junction 0.489473684 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood TNF signaling pathway 0 0.667647059 0.51 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Toll-like receptor signaling pathway 0 0.608823529 0 yes serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Transcriptional misregulation in cancer -0.596491228 0.573529412 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Vibrio cholerae infection 0.60877193 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Viral myocarditis 0.461403509 0 0 serum_aminoacids kegg 0.122 NA up no no no no no Ethanolamine+blood Wnt signaling pathway 0 -0.552941176 0 serum_aminoacids kegg 0.122 NA up no no no no no Ether lipid metabolism "Alanine, aspartate and glutamate metabolism" -0.5 -0.540513834 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Amino sugar and nucleotide sugar metabolism 0 0.462450593 0.432175032 kegg kegg NA NA no no no no no no Ether lipid metabolism Arginine and proline metabolism -0.476521739 -0.510869565 -0.462548263 kegg kegg NA NA no no no no up no Ether lipid metabolism Arginine biosynthesis -0.530434783 -0.601778656 -0.468725869 kegg kegg NA NA no no no no no no Ether lipid metabolism Ascorbate and aldarate metabolism 0 0.459486166 0.614929215 kegg kegg NA NA no no no no no no Ether lipid metabolism beta-Alanine metabolism -0.466956522 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Citrate cycle (TCA cycle) 0 0.423913043 0.493436293 kegg kegg NA NA no no no no no no Ether lipid metabolism Fatty acid biosynthesis -0.594782609 -0.595849802 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Fatty acid degradation -0.636521739 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Fatty acid elongation -0.410434783 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Fructose and mannose metabolism -0.420869565 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Galactose metabolism -0.456521739 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Glycerolipid metabolism 0 0 0.544916345 kegg kegg NA NA no no no no no up Ether lipid metabolism Glycerophospholipid metabolism 0.439130435 0 0.711969112 kegg kegg NA NA no no no no no up Ether lipid metabolism "Glycine, serine and threonine metabolism" 0 0.541501976 0 kegg kegg NA NA no no no no up no Ether lipid metabolism Glycolysis / Gluconeogenesis -0.571304348 0 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.551351351 kegg kegg NA NA no no no no no no Ether lipid metabolism Glycosaminoglycan biosynthesis - keratan sulfate 0.580869565 0 0.407979408 kegg kegg NA NA no no no no no no Ether lipid metabolism Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.651185771 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Inositol phosphate metabolism 0 0 0.635006435 kegg kegg NA NA no no no no no no Ether lipid metabolism Lysine degradation 0 0.422924901 0.577348777 kegg kegg NA NA no no no no no no Ether lipid metabolism Mannose type O-glycan biosynthesis 0.645217391 0.416007905 0.585070785 kegg kegg NA NA no no no no no no Ether lipid metabolism N-Glycan biosynthesis 0 0.587944664 0.411325611 kegg kegg NA NA no no no no no no Ether lipid metabolism Other glycan degradation 0 0 0.428828829 kegg kegg NA NA no no no no no no Ether lipid metabolism Other types of O-glycan biosynthesis 0.517391304 0.506916996 0.624967825 kegg kegg NA NA no no no no no no Ether lipid metabolism Oxidative phosphorylation 0.667826087 0.456521739 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Pentose and glucuronate interconversions 0 0.60770751 0.482368082 kegg kegg NA NA no no no no no no Ether lipid metabolism Pentose phosphate pathway 0 -0.682806324 -0.421879022 kegg kegg NA NA no no no no no no Ether lipid metabolism Purine metabolism 0 0.648221344 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Pyrimidine metabolism -0.550434783 0.634387352 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Selenocompound metabolism 0 0.459486166 0.624453024 kegg kegg NA NA no no no no no no Ether lipid metabolism Starch and sucrose metabolism -0.415652174 -0.438735178 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Steroid biosynthesis 0.42173913 0.421936759 0.631660232 kegg kegg NA NA no no no no no no Ether lipid metabolism Steroid hormone biosynthesis 0 0.453557312 0.573487773 kegg kegg NA NA no no no no no no Ether lipid metabolism Synthesis and degradation of ketone bodies 0 0.567193676 0.581209781 kegg kegg NA NA no no no no no no Ether lipid metabolism Tyrosine metabolism 0 0.435770751 0 kegg kegg NA NA no no no no no no Ether lipid metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0 0.5 0.581209781 kegg kegg NA NA no no no no no no Ether lipid metabolism "Valine, leucine and isoleucine degradation" 0 0.531620553 0.471042471 kegg kegg NA NA no no no no no no Ether lipid metabolism Various types of N-glycan biosynthesis 0 0.497035573 0 kegg kegg NA NA no no no no no no Faecalibacterium Eggerthella -0.54461403 0 0 butyrate-producing Genus Genus 0.0039 0.912 no dn dn no no no Faecalibacterium Roseburia 0 0.726977954 0 butyrate-producing butyrate-producing Genus Genus 0.0039 0.495 no dn dn no no no Fanconi anemia pathway 2-Oxocarboxylic acid metabolism 0 0.541501976 0.435778636 kegg kegg NA NA no no no no no no Fanconi anemia pathway ABC transporters 0.572173913 0.583003953 0.413899614 kegg kegg NA NA no no no no up up Fanconi anemia pathway Amino sugar and nucleotide sugar metabolism 0 0.681818182 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Aminoacyl-tRNA biosynthesis 0.719130435 0.858695652 0.725611326 kegg kegg NA NA no no no no no no Fanconi anemia pathway Antifolate resistance 0.496521739 0.671936759 0.432689833 kegg kegg NA NA no no no no no no Fanconi anemia pathway Arachidonic acid metabolism 0 0 -0.410553411 kegg kegg NA NA no no no no no no Fanconi anemia pathway Arginine biosynthesis 0 0 -0.461518662 kegg kegg NA NA no no no no no no Fanconi anemia pathway Ascorbate and aldarate metabolism 0.410434783 0 0.568082368 kegg kegg NA NA no no no no no no Fanconi anemia pathway Basal transcription factors 0.67826087 0.77173913 0.856370656 kegg kegg NA NA no no no no no no Fanconi anemia pathway Base excision repair 0.852173913 0.860671937 0.841698842 kegg kegg NA NA no no no no no no Fanconi anemia pathway Biosynthesis of amino acids 0 -0.52173913 -0.576319176 kegg kegg NA NA no no no no no no Fanconi anemia pathway Biosynthesis of cofactors 0 0.641304348 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Biosynthesis of unsaturated fatty acids 0.615652174 0 0.401287001 kegg kegg NA NA no no no no no no Fanconi anemia pathway Butanoate metabolism 0.517391304 0.518774704 0.58970399 kegg kegg NA NA no no no no no no Fanconi anemia pathway Citrate cycle (TCA cycle) 0.589565217 0.488142292 0.674646075 kegg kegg NA NA no no no no no no Fanconi anemia pathway Cysteine and methionine metabolism 0.725217391 0.418972332 0.673101673 kegg kegg NA NA no no no no no no Fanconi anemia pathway DNA replication 0.916521739 0.735177866 0.863063063 kegg kegg NA NA no no no no no no Fanconi anemia pathway Drug metabolism - cytochrome P450 0 0.459486166 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway EGFR tyrosine kinase inhibitor resistance 0.407826087 0 0.434749035 kegg kegg NA NA no no no no no no Fanconi anemia pathway Ether lipid metabolism 0 0.537549407 0.625482625 kegg kegg NA NA no no no no no no Fanconi anemia pathway Folate biosynthesis 0.48 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Glycerolipid metabolism 0 0.503952569 0.508622909 kegg kegg NA NA no no no no no up Fanconi anemia pathway Glycerophospholipid metabolism 0 0.604743083 0.695238095 kegg kegg NA NA no no no no no up Fanconi anemia pathway "Glycine, serine and threonine metabolism" 0 0.493083004 0 kegg kegg NA NA no no no no up no Fanconi anemia pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.508695652 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.42687747 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Glycosaminoglycan degradation -0.700869565 -0.425889328 0 kegg kegg NA NA no no no no no up Fanconi anemia pathway Glycosphingolipid biosynthesis - ganglio series 0 0.710474308 0.503474903 kegg kegg NA NA no no no no no no Fanconi anemia pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.692173913 0.712450593 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Glyoxylate and dicarboxylate metabolism 0 0 -0.465122265 kegg kegg NA NA no no no no no no Fanconi anemia pathway Homologous recombination 0.930434783 0.902173913 0.913770914 kegg kegg NA NA no no no no no no Fanconi anemia pathway Inositol phosphate metabolism 0.470434783 0.648221344 0.648906049 kegg kegg NA NA no no no no no no Fanconi anemia pathway Lysine degradation 0.505217391 0.742094862 0.670527671 kegg kegg NA NA no no no no no no Fanconi anemia pathway Mannose type O-glycan biosynthesis 0 0.475296443 0.565250965 kegg kegg NA NA no no no no no no Fanconi anemia pathway Mismatch repair 0.813913043 0.679841897 0.72020592 kegg kegg NA NA no no no no no no Fanconi anemia pathway mRNA surveillance pathway 0 0.453557312 0.596911197 kegg kegg NA NA no no no no no no Fanconi anemia pathway Mucin type O-glycan biosynthesis 0.58173913 0.467391304 0.447104247 kegg kegg NA NA no no no no no no Fanconi anemia pathway N-Glycan biosynthesis 0.640869565 0.523715415 0.743114543 kegg kegg NA NA no no no no no no Fanconi anemia pathway Nicotinate and nicotinamide metabolism 0 0 -0.48030888 kegg kegg NA NA no no no no no no Fanconi anemia pathway Nitrogen metabolism 0 0 -0.525611326 kegg kegg NA NA no no no no no no Fanconi anemia pathway Non-homologous end-joining 0.491304348 0 0.405920206 kegg kegg NA NA no no no no no no Fanconi anemia pathway Nucleotide excision repair 0.926956522 0.803359684 0.868468468 kegg kegg NA NA no no no no no no Fanconi anemia pathway One carbon pool by folate 0.867826087 0.782608696 0.823938224 kegg kegg NA NA no no no no no no Fanconi anemia pathway Other glycan degradation 0 0.429841897 0.475933076 kegg kegg NA NA no no no no no no Fanconi anemia pathway Other types of O-glycan biosynthesis 0.584347826 0.769762846 0.798455598 kegg kegg NA NA no no no no no no Fanconi anemia pathway Pentose and glucuronate interconversions 0.513043478 0.529644269 0.616473616 kegg kegg NA NA no no no no no no Fanconi anemia pathway Pentose phosphate pathway -0.48 -0.668972332 -0.563449163 kegg kegg NA NA no no no no no no Fanconi anemia pathway Phenylalanine metabolism 0 0.428853755 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Platinum drug resistance 0.669565217 0.750988142 0.707593308 kegg kegg NA NA no no no no no no Fanconi anemia pathway PPAR signaling pathway 0 -0.428853755 -0.654311454 kegg kegg NA NA no no no no no no Fanconi anemia pathway Primary bile acid biosynthesis 0.736521739 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Propanoate metabolism 0.685217391 0 0.612612613 kegg kegg NA NA no no no no no no Fanconi anemia pathway Protein export 0.500869565 0 0.456628057 kegg kegg NA NA no no no no no no Fanconi anemia pathway Purine metabolism 0 0.506916996 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Pyrimidine metabolism 0.428695652 0.56916996 0.401801802 kegg kegg NA NA no no no no no no Fanconi anemia pathway Pyruvate metabolism 0.769565217 0.428853755 0.520720721 kegg kegg NA NA no no no no no no Fanconi anemia pathway Retinol metabolism 0.522608696 0.669960474 0.668983269 kegg kegg NA NA no no no no no no Fanconi anemia pathway Ribosome biogenesis in eukaryotes 0.804347826 0.903162055 0.914285714 kegg kegg NA NA no no no no no no Fanconi anemia pathway RNA degradation 0 0.432806324 0.680823681 kegg kegg NA NA no no no no no no Fanconi anemia pathway RNA polymerase 0.636521739 0.780632411 0.716859717 kegg kegg NA NA no no no no no no Fanconi anemia pathway RNA transport 0.648695652 0 0.403088803 kegg kegg NA NA no no no no no no Fanconi anemia pathway Selenocompound metabolism 0.62173913 0.89229249 0.877477477 kegg kegg NA NA no no no no no no Fanconi anemia pathway Sphingolipid metabolism -0.722608696 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Spliceosome 0.753913043 0.776679842 0.785842986 kegg kegg NA NA no no no no no no Fanconi anemia pathway Steroid biosynthesis 0.431304348 0.504940711 0.574517375 kegg kegg NA NA no no no no no no Fanconi anemia pathway Steroid hormone biosynthesis 0 0.492094862 0.524324324 kegg kegg NA NA no no no no no no Fanconi anemia pathway Synthesis and degradation of ketone bodies 0.849565217 0.765810277 0.781724582 kegg kegg NA NA no no no no no no Fanconi anemia pathway Terpenoid backbone biosynthesis 0.649565217 0.674901186 0.724324324 kegg kegg NA NA no no no no no no Fanconi anemia pathway Thiamine metabolism 0.554782609 0 0 kegg kegg NA NA no no no no no no Fanconi anemia pathway Tryptophan metabolism 0.513043478 0 0.522265122 kegg kegg NA NA no no no no up no Fanconi anemia pathway Tyrosine metabolism 0.439130435 0.536561265 0.4002574 kegg kegg NA NA no no no no no no Fanconi anemia pathway Ubiquinone and other terpenoid-quinone biosynthesis 0.686956522 0.738142292 0.730501931 kegg kegg NA NA no no no no no no Fanconi anemia pathway "Valine, leucine and isoleucine degradation" 0.736521739 0.645256917 0.68030888 kegg kegg NA NA no no no no no no Fanconi anemia pathway Various types of N-glycan biosynthesis 0.502608696 0.513833992 0.727155727 kegg kegg NA NA no no no no no no Fat digestion and absorption 2-Oxocarboxylic acid metabolism 0 -0.544466403 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Adrenergic signaling in cardiomyocytes -0.52173913 -0.753952569 -0.662548263 yes kegg kegg NA NA no up up no no up Fat digestion and absorption AGE-RAGE signaling pathway in diabetic complications 0 0.683794466 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption "Alanine, aspartate and glutamate metabolism" 0.72173913 0.709486166 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Aldosterone synthesis and secretion -0.604347826 -0.682806324 -0.656628057 yes kegg kegg NA NA no up up no up up Fat digestion and absorption alpha-Linolenic acid metabolism 0.564347826 0.632411067 0.578378378 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Amino sugar and nucleotide sugar metabolism 0.506086957 0 0.47027027 yes kegg kegg NA NA no up up no no no Fat digestion and absorption AMPK signaling pathway 0 -0.494071146 -0.478507079 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Apelin signaling pathway 0 -0.574110672 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Apoptosis 0.48 0.497035573 0.483140283 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Arginine and proline metabolism 0.85826087 0.640316206 0.535649936 yes kegg kegg NA NA no up up no up no Fat digestion and absorption Arginine biosynthesis 0.784347826 0.735177866 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Axon guidance -0.508695652 0 0 yes kegg kegg NA NA no up up no up up Fat digestion and absorption Basal transcription factors 0 -0.508893281 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Biosynthesis of amino acids 0.617391304 0.778656126 0.617503218 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Calcium signaling pathway -0.688695652 -0.563241107 -0.55006435 yes kegg kegg NA NA no up up no up up Fat digestion and absorption cAMP signaling pathway -0.408695652 0 0 yes yes kegg kegg NA NA no up up no up up Fat digestion and absorption Carbon metabolism 0.420869565 0.457509881 0.708622909 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Cardiac muscle contraction -0.503478261 -0.626482213 0 yes kegg kegg NA NA no up up no no up Fat digestion and absorption Cell cycle 0 -0.618577075 -0.542857143 yes kegg kegg NA NA no up up no no no Fat digestion and absorption cGMP-PKG signaling pathway 0 0.774703557 0.538223938 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Chemokine signaling pathway 0 0.608695652 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Circadian entrainment 0 0 -0.447876448 yes kegg kegg NA NA no up up no up up Fat digestion and absorption Circadian rhythm -0.520869565 -0.663043478 -0.411583012 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Collecting duct acid secretion 0 0.628458498 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Complement and coagulation cascades 0.655652174 0.839920949 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Cortisol synthesis and secretion -0.436521739 -0.43972332 -0.537966538 yes kegg kegg NA NA no up up no no up Fat digestion and absorption Cushing syndrome -0.587826087 -0.590909091 -0.63963964 yes kegg kegg NA NA no up up no no up Fat digestion and absorption Cytokine-cytokine receptor interaction 0 0.627470356 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption DNA replication 0 -0.51284585 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Dopaminergic synapse -0.416521739 -0.433794466 -0.642471042 yes kegg kegg NA NA no up up no up no Fat digestion and absorption Drug metabolism - cytochrome P450 0 0 0.407464607 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Drug metabolism - other enzymes 0.408695652 0 0.497039897 yes kegg kegg NA NA no up up no no no Fat digestion and absorption ECM-receptor interaction 0 0 -0.492149292 yes kegg kegg NA NA no up up no up up Fat digestion and absorption EGFR tyrosine kinase inhibitor resistance -0.446956522 -0.576086957 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Endocrine and other factor-regulated calcium reabsorption -0.56173913 -0.613636364 -0.578635779 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Endocrine resistance -0.453043478 0 -0.564221364 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Estrogen signaling pathway 0 0 -0.526640927 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Ether lipid metabolism -0.60173913 -0.504940711 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Fatty acid biosynthesis 0.78173913 0.787549407 0.418790219 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Fatty acid degradation 0.764347826 0.652173913 0.543371943 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Fatty acid metabolism 0.730434783 0.752964427 0.491119691 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Fc epsilon RI signaling pathway 0 0.612648221 0.575032175 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Fc gamma R-mediated phagocytosis 0.613913043 0.788537549 0.494465894 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Folate biosynthesis 0 -0.587944664 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Fructose and mannose metabolism 0.507826087 0 0.632689833 yes kegg kegg NA NA no up up no no no Fat digestion and absorption GABAergic synapse 0.610434783 0.630434783 0 yes kegg kegg NA NA no up up no up up Fat digestion and absorption Galactose metabolism 0.533043478 0.633399209 0.594079794 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Glucagon signaling pathway -0.516521739 -0.685770751 -0.677477477 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Glutathione metabolism 0 -0.420948617 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.624347826 0 0.530759331 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.539525692 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Glycosaminoglycan biosynthesis - keratan sulfate -0.649565217 -0.644268775 -0.413127413 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Glycosaminoglycan degradation 0 0.418972332 0.552638353 yes kegg kegg NA NA no up up no no up Fat digestion and absorption Glyoxylate and dicarboxylate metabolism 0.724347826 0.742094862 0.46048906 yes kegg kegg NA NA no up up no no no Fat digestion and absorption GnRH signaling pathway -0.482608696 -0.416007905 -0.616216216 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Hedgehog signaling pathway -0.476521739 -0.469367589 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption HIF-1 signaling pathway 0 -0.422924901 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Hippo signaling pathway - multiple species 0 0.445652174 0.541827542 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Histidine metabolism 0.502608696 0 0.462033462 yes kegg kegg NA NA no up up no no no Fat digestion and absorption IL-17 signaling pathway 0.495652174 0.793478261 0.615701416 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Inflammatory mediator regulation of TRP channels -0.613913043 -0.637351779 -0.718146718 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Insulin secretion -0.549565217 -0.586956522 -0.525611326 yes yes kegg kegg NA NA no up up no up up Fat digestion and absorption Insulin signaling pathway 0 -0.565217391 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Long-term depression 0 0 -0.411325611 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Longevity regulating pathway 0 0 -0.442728443 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Lysine degradation -0.415652174 -0.565217391 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Lysosome 0.430434783 0.639328063 0.814414414 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Mannose type O-glycan biosynthesis -0.59826087 -0.581027668 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Melanogenesis -0.624347826 -0.670948617 -0.757014157 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Metabolism of xenobiotics by cytochrome P450 0 0 0.441956242 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Mitophagy - animal -0.467826087 -0.453557312 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption mRNA surveillance pathway -0.609565217 -0.920948617 -0.462290862 yes kegg kegg NA NA no up up no no no Fat digestion and absorption mTOR signaling pathway 0 -0.586956522 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption N-Glycan biosynthesis -0.611304348 -0.730237154 -0.421106821 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Neuroactive ligand-receptor interaction 0 0.695652174 0.677477477 yes kegg kegg NA NA no up up up up up Fat digestion and absorption Neutrophil extracellular trap formation 0.63826087 0.811264822 0.58996139 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Nicotinate and nicotinamide metabolism 0.797391304 0.753952569 0.701158301 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Nitrogen metabolism 0.693043478 0.673913043 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption NOD-like receptor signaling pathway 0.756521739 0.483201581 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Non-alcoholic fatty liver disease -0.509565217 -0.650197628 -0.430888031 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Olfactory transduction 0.533043478 0.827075099 0.722522523 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Oocyte meiosis -0.459130435 0 -0.502702703 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Osteoclast differentiation 0.569565217 0.688735178 0.553153153 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Other types of O-glycan biosynthesis -0.428695652 -0.471343874 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Oxidative phosphorylation -0.486956522 -0.599802372 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Pancreatic secretion -0.555652174 -0.526679842 -0.558558559 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Pantothenate and CoA biosynthesis 0.686956522 0.792490119 0.716602317 yes kegg kegg NA NA no up up no no dn Fat digestion and absorption "Parathyroid hormone synthesis, secretion and action" -0.460869565 -0.553359684 -0.550836551 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Pentose and glucuronate interconversions 0 -0.605731225 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Pentose phosphate pathway 0.546956522 0.79743083 0.715315315 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Peroxisome 0.691304348 0.799407115 0.409009009 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Phagosome 0 0.563241107 0.416216216 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Phosphatidylinositol signaling system -0.634782609 0 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption PI3K-Akt signaling pathway 0 -0.468379447 0 yes yes kegg kegg NA NA no up up no up up Fat digestion and absorption PPAR signaling pathway 0.589565217 0.571146245 0.466151866 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Prolactin signaling pathway 0 0.511857708 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Protein digestion and absorption 0.537391304 0.475296443 0.424453024 yes yes kegg kegg NA NA no up up no up up Fat digestion and absorption Protein export -0.634782609 -0.685770751 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Protein processing in endoplasmic reticulum -0.50173913 -0.79743083 -0.531788932 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Proximal tubule bicarbonate reclamation 0 -0.51284585 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Pyrimidine metabolism 0.50173913 0 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Pyruvate metabolism 0 -0.427865613 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Ras signaling pathway -0.573043478 -0.552371542 0 yes yes kegg kegg NA NA no up up no up up Fat digestion and absorption Regulation of lipolysis in adipocytes 0 0 -0.515057915 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Renin secretion 0 -0.51284585 -0.596396396 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Renin-angiotensin system 0.477391304 0.643280632 0.591505792 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Retinol metabolism 0.415652174 0 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Retrograde endocannabinoid signaling 0 -0.492094862 0 yes kegg kegg NA NA no up up no no up Fat digestion and absorption Ribosome -0.597391304 -0.543478261 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Ribosome biogenesis in eukaryotes -0.437391304 -0.546442688 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption RNA degradation -0.691304348 -0.867588933 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption RNA polymerase -0.44173913 -0.711462451 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption RNA transport 0 -0.523715415 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Signaling pathways regulating pluripotency of stem cells -0.446956522 -0.442687747 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Sphingolipid metabolism 0 0 0.594851995 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Spliceosome 0 -0.423913043 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Starch and sucrose metabolism 0.793913043 0.807312253 0.784298584 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Synaptic vesicle cycle 0.469565217 0.876482213 0.762162162 yes kegg kegg NA NA no up up no up up Fat digestion and absorption TGF-beta signaling pathway -0.700869565 -0.565217391 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Thermogenesis -0.592173913 -0.623517787 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Thyroid hormone synthesis -0.527826087 -0.51284585 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Toll-like receptor signaling pathway 0 0.522727273 0 yes yes kegg kegg NA NA no up up no no no Fat digestion and absorption Ubiquitin mediated proteolysis -0.616521739 -0.54743083 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Various types of N-glycan biosynthesis -0.450434783 -0.634387352 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Vascular smooth muscle contraction -0.58 0 -0.467953668 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Vasopressin-regulated water reabsorption -0.526956522 -0.513833992 -0.564993565 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Viral protein interaction with cytokine and cytokine receptor 0 0.576086957 0 yes kegg kegg NA NA no up up no no no Fat digestion and absorption Wnt signaling pathway -0.733043478 -0.81027668 0 yes kegg kegg NA NA no up up no no no Fatty acid biosynthesis Ascorbate and aldarate metabolism 0 -0.472332016 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Citrate cycle (TCA cycle) 0 -0.653162055 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Fructose and mannose metabolism 0 0.418972332 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Galactose metabolism 0 0.710474308 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Glycolysis / Gluconeogenesis 0 -0.459486166 0 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Pentose and glucuronate interconversions 0 -0.817193676 -0.495752896 kegg kegg NA NA no no no no no no Fatty acid biosynthesis Pentose phosphate pathway 0 0.688735178 0.587902188 kegg kegg NA NA no no no no no no Fatty acid degradation Ascorbate and aldarate metabolism 0 0 0.522007722 kegg kegg NA NA no no no no no no Fatty acid degradation Citrate cycle (TCA cycle) 0 0 0.52020592 kegg kegg NA NA no no no no no no Fatty acid degradation Fatty acid biosynthesis 0.783478261 0.831027668 0.536164736 kegg kegg NA NA no no no no no no Fatty acid degradation Fatty acid elongation 0.454782609 0 0.542857143 kegg kegg NA NA no no no no no no Fatty acid degradation Fructose and mannose metabolism 0.534782609 0.490118577 0.541827542 kegg kegg NA NA no no no no no no Fatty acid degradation Galactose metabolism 0.569565217 0.712450593 0 kegg kegg NA NA no no no no no no Fatty acid degradation Glycolysis / Gluconeogenesis 0.553043478 0 0.46023166 kegg kegg NA NA no no no no no no Fatty acid degradation Pentose and glucuronate interconversions 0 -0.447628458 0 kegg kegg NA NA no no no no no no Fatty acid degradation Pentose phosphate pathway 0 0.503952569 0.44967825 kegg kegg NA NA no no no no no no Fatty acid elongation Ascorbate and aldarate metabolism 0.590434783 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Citrate cycle (TCA cycle) 0.699130435 0.683794466 0.52046332 kegg kegg NA NA no no no no no no Fatty acid elongation Fructose and mannose metabolism 0.491304348 -0.443675889 0 kegg kegg NA NA no no no no no no Fatty acid elongation Galactose metabolism 0.633913043 0 0 kegg kegg NA NA no no no no no no Fatty acid elongation Glycolysis / Gluconeogenesis 0.693043478 0.745059289 0.701158301 kegg kegg NA NA no no no no no no Fatty acid elongation Pentose and glucuronate interconversions 0.640869565 0.48715415 0.443243243 kegg kegg NA NA no no no no no no Fatty acid metabolism "Alanine, aspartate and glutamate metabolism" 0.688695652 0.750988142 0.532561133 kegg kegg NA NA no no no no no no Fatty acid metabolism alpha-Linolenic acid metabolism 0.579130435 0.707509881 0.56962677 kegg kegg NA NA no no no no no no Fatty acid metabolism Amino sugar and nucleotide sugar metabolism 0.597391304 0 0.454054054 kegg kegg NA NA no no no no no no Fatty acid metabolism Aminoacyl-tRNA biosynthesis 0.513913043 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Arginine and proline metabolism 0.639130435 0.652173913 0 kegg kegg NA NA no no no no up no Fatty acid metabolism Arginine biosynthesis 0.72173913 0.741106719 0.436808237 kegg kegg NA NA no no no no no no Fatty acid metabolism beta-Alanine metabolism 0.647826087 0 0.527670528 kegg kegg NA NA no no no no no no Fatty acid metabolism Biosynthesis of unsaturated fatty acids 0.57826087 0 0.556756757 kegg kegg NA NA no no no no no no Fatty acid metabolism Butanoate metabolism 0.477391304 0 0.459202059 kegg kegg NA NA no no no no no no Fatty acid metabolism Carbon metabolism 0.603478261 0 0.593050193 kegg kegg NA NA no no no no no no Fatty acid metabolism Citrate cycle (TCA cycle) 0 0 0.425225225 kegg kegg NA NA no no no no no no Fatty acid metabolism Drug metabolism - other enzymes 0.53826087 -0.43972332 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Ether lipid metabolism -0.724347826 -0.440711462 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Fatty acid biosynthesis 0.723478261 0.807312253 0.502702703 kegg kegg NA NA no no no no no no Fatty acid metabolism Fatty acid degradation 0.933913043 0.941699605 0.94002574 kegg kegg NA NA no no no no no no Fatty acid metabolism Fatty acid elongation 0.62 0 0.593307593 kegg kegg NA NA no no no no no no Fatty acid metabolism Folate biosynthesis 0 -0.598814229 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Fructose and mannose metabolism 0.595652174 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Galactose metabolism 0.694782609 0.65513834 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Glutathione metabolism 0 -0.524703557 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Glycolysis / Gluconeogenesis 0.577391304 0 0.453539254 kegg kegg NA NA no no no no no no Fatty acid metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.447628458 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.650434783 -0.694664032 -0.404890605 kegg kegg NA NA no no no no no no Fatty acid metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.410434783 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Glyoxylate and dicarboxylate metabolism 0.826956522 0.750988142 0.46975547 kegg kegg NA NA no no no no no no Fatty acid metabolism Histidine metabolism 0.586086957 0.42687747 0.524581725 kegg kegg NA NA no no no no no no Fatty acid metabolism Mannose type O-glycan biosynthesis -0.59826087 -0.431818182 0 kegg kegg NA NA no no no no no no Fatty acid metabolism N-Glycan biosynthesis 0 -0.561264822 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Nicotinate and nicotinamide metabolism 0.68173913 0.708498024 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Nitrogen metabolism 0.509565217 0.62944664 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Oxidative phosphorylation -0.72 -0.826086957 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Pantothenate and CoA biosynthesis 0.632173913 0.798418972 0.673101673 kegg kegg NA NA no no no no no dn Fatty acid metabolism Pentose and glucuronate interconversions 0 -0.436758893 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Pentose phosphate pathway 0 0.609683794 0.420849421 kegg kegg NA NA no no no no no no Fatty acid metabolism Primary bile acid biosynthesis 0.502608696 0 0.609009009 kegg kegg NA NA no no no no no no Fatty acid metabolism Propanoate metabolism 0.423478261 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Pyrimidine metabolism 0.71826087 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Retinol metabolism 0.609565217 0 0.425225225 kegg kegg NA NA no no no no no no Fatty acid metabolism Starch and sucrose metabolism 0.642608696 0.806324111 0.426769627 kegg kegg NA NA no no no no no no Fatty acid metabolism Steroid hormone biosynthesis 0.414782609 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism Synthesis and degradation of ketone bodies 0 0 0.416473616 kegg kegg NA NA no no no no no no Fatty acid metabolism Tryptophan metabolism 0.575652174 0 0.572715573 kegg kegg NA NA no no no no up no Fatty acid metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.465217391 0 0 kegg kegg NA NA no no no no no no Fatty acid metabolism "Valine, leucine and isoleucine degradation" 0.466086957 0 0.532046332 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway 2-Oxocarboxylic acid metabolism -0.506956522 -0.659090909 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Adherens junction 0 -0.451581028 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Adrenergic signaling in cardiomyocytes 0 -0.606719368 0 kegg kegg NA NA no no no no no up Fc epsilon RI signaling pathway "Alanine, aspartate and glutamate metabolism" 0 0.761857708 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway alpha-Linolenic acid metabolism 0 0.527667984 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Amino sugar and nucleotide sugar metabolism -0.620869565 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Aminoacyl-tRNA biosynthesis -0.445217391 -0.548418972 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway AMPK signaling pathway 0 -0.472332016 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Antifolate resistance 0 -0.428853755 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Apelin signaling pathway -0.414782609 -0.815217391 -0.61981982 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Apoptosis 0 0.909090909 0.59047619 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Arachidonic acid metabolism -0.528695652 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Arginine and proline metabolism 0 0.778656126 0.416731017 kegg kegg NA NA no no no no up no Fc epsilon RI signaling pathway Arginine biosynthesis 0 0.754940711 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Ascorbate and aldarate metabolism 0 -0.423913043 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Autophagy - animal 0 0.77173913 0.513770914 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway B cell receptor signaling pathway 0.712173913 0.84486166 0.601544402 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Basal transcription factors 0 -0.583992095 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Base excision repair 0 -0.536561265 -0.459202059 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway beta-Alanine metabolism -0.44173913 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Biosynthesis of amino acids 0 0.71541502 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Biosynthesis of cofactors -0.694782609 -0.750988142 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Biosynthesis of unsaturated fatty acids -0.419130435 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Butanoate metabolism -0.620869565 -0.796442688 -0.60978121 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway C-type lectin receptor signaling pathway 0.613913043 0.851778656 0.513513514 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway cAMP signaling pathway 0 0.515810277 0 yes kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway Carbon metabolism -0.500869565 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Cardiac muscle contraction 0 -0.653162055 0 kegg kegg NA NA no no no no no up Fc epsilon RI signaling pathway Cell adhesion molecules 0 0.583003953 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Cell cycle 0 -0.744071146 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Cellular senescence 0 0.729249012 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway cGMP-PKG signaling pathway 0.546956522 0.809288538 0.564993565 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Chemokine signaling pathway 0.43826087 0.691699605 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Citrate cycle (TCA cycle) -0.57826087 -0.796442688 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Complement and coagulation cascades 0 0.723320158 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Cysteine and methionine metabolism -0.686956522 -0.82312253 -0.659202059 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway DNA replication -0.46173913 -0.833992095 -0.466151866 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Dorea -0.466956522 0 0 kegg Genus NA 0.00362 no no no up no dn Fc epsilon RI signaling pathway Drug metabolism - cytochrome P450 -0.615652174 -0.835968379 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Drug metabolism - other enzymes -0.62 -0.768774704 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway ECM-receptor interaction -0.506956522 -0.526679842 0 kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.68972332 -0.589446589 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Endocytosis 0 0.630434783 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway ErbB signaling pathway 0.730434783 0.5256917 0.435778636 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Ether lipid metabolism 0 -0.577075099 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Fanconi anemia pathway 0 -0.488142292 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Fatty acid biosynthesis 0 0.826086957 0.418275418 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Fatty acid degradation 0 0.562252964 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Fatty acid metabolism 0 0.517786561 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Focal adhesion 0 -0.481225296 0 kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway Folate biosynthesis 0 -0.441699605 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway FoxO signaling pathway 0 0.533596838 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Fructose and mannose metabolism -0.450434783 0.458498024 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Galactose metabolism 0 0.650197628 0.424195624 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Glutathione metabolism -0.527826087 -0.792490119 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway "Glycine, serine and threonine metabolism" -0.543478261 -0.603754941 0 kegg kegg NA NA no no no no up no Fc epsilon RI signaling pathway Glycolysis / Gluconeogenesis -0.706086957 -0.592885375 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.450434783 0.82312253 0.683140283 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0.426956522 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Glycosaminoglycan degradation 0 0.556324111 0.4996139 kegg kegg NA NA no no no no no up Fc epsilon RI signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 -0.476284585 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.631304348 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.769762846 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Hedgehog signaling pathway 0.504347826 -0.457509881 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway HIF-1 signaling pathway 0 -0.645256917 -0.468468468 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Hippo signaling pathway 0 -0.565217391 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Hippo signaling pathway - multiple species 0.43826087 0.649209486 0.72972973 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Homologous recombination 0 0 -0.468468468 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway IL-17 signaling pathway 0.433043478 0.806324111 0.537194337 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway JAK-STAT signaling pathway 0 0.664031621 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Linoleic acid metabolism -0.549565217 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Lysosome 0.486956522 0.651185771 0.684942085 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Mannose type O-glycan biosynthesis 0.44173913 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Metabolism of xenobiotics by cytochrome P450 -0.59826087 -0.757905138 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Mismatch repair -0.556521739 -0.756916996 -0.528185328 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Mitophagy - animal 0 -0.564229249 -0.550579151 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway mRNA surveillance pathway 0 -0.641304348 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway mTOR signaling pathway 0 -0.699604743 -0.546975547 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Mucin type O-glycan biosynthesis -0.566086957 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway N-Glycan biosynthesis 0 -0.818181818 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Natural killer cell mediated cytotoxicity 0 0.672924901 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Neuroactive ligand-receptor interaction 0 0.597826087 0.48983269 kegg kegg NA NA no no no up up up Fc epsilon RI signaling pathway Neutrophil extracellular trap formation 0 0.735177866 0.420592021 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway NF-kappa B signaling pathway 0.446956522 0.802371542 0.404375804 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Nicotinate and nicotinamide metabolism 0 0.898221344 0.58043758 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Nitrogen metabolism 0 0.705533597 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway NOD-like receptor signaling pathway 0 0.828063241 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Non-homologous end-joining -0.556521739 -0.497035573 -0.506821107 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Notch signaling pathway 0.775652174 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Nucleotide excision repair -0.469565217 -0.791501976 -0.541055341 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway One carbon pool by folate -0.419130435 -0.755928854 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Oocyte meiosis 0 -0.674901186 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Osteoclast differentiation 0 0.906126482 0.653024453 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Oxidative phosphorylation 0 -0.681818182 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Pantothenate and CoA biosynthesis 0 0.751976285 0.405405405 kegg kegg NA NA no no no no no dn Fc epsilon RI signaling pathway Paraprevotella 0 -0.441395835 0 kegg Genus NA 0.118 no no no no no no Fc epsilon RI signaling pathway Pentose and glucuronate interconversions -0.670434783 -0.840909091 -0.446589447 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Pentose phosphate pathway 0 0.744071146 0.476190476 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Peroxisome 0 0.653162055 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Phagosome 0 0.641304348 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Phenylalanine metabolism -0.417391304 -0.646245059 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Phospholipase D signaling pathway 0.686956522 0.783596838 0.602059202 kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway PI3K-Akt signaling pathway 0 0 -0.51969112 yes kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway Porphyrin and chlorophyll metabolism -0.573913043 -0.589920949 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway PPAR signaling pathway 0 0.800395257 0.408751609 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Primary bile acid biosynthesis -0.526086957 -0.415019763 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Propanoate metabolism -0.697391304 -0.780632411 -0.637323037 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Proteasome 0 -0.623517787 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Protein export 0 -0.782608696 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Protein processing in endoplasmic reticulum -0.611304348 -0.880434783 -0.758558559 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Purine metabolism -0.433913043 -0.603754941 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Pyrimidine metabolism -0.447826087 -0.712450593 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Pyruvate metabolism -0.636521739 -0.890316206 -0.686743887 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Ras signaling pathway 0 -0.608695652 0 yes kegg kegg NA NA no no no no up up Fc epsilon RI signaling pathway Renin-angiotensin system 0 0.75 0.555727156 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Retinol metabolism -0.537391304 -0.564229249 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Ribosome 0 -0.716403162 -0.641698842 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Ribosome biogenesis in eukaryotes 0 -0.682806324 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway RIG-I-like receptor signaling pathway 0 0.773715415 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway RNA degradation 0 -0.780632411 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway RNA polymerase 0 -0.81916996 -0.437065637 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway RNA transport -0.525217391 -0.62055336 -0.665894466 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Sarcina 0 0.422326513 0 kegg Genus NA 0.0703 no no no no no no Fc epsilon RI signaling pathway Signaling pathways regulating pluripotency of stem cells 0.544347826 0 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway SNARE interactions in vesicular transport 0 0.485177866 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Sphingolipid metabolism 0 0 0.581724582 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Sphingolipid signaling pathway 0.657391304 0.669960474 0.517374517 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Starch and sucrose metabolism 0 0.803359684 0.602059202 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Steroid biosynthesis 0 -0.605731225 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Steroid hormone biosynthesis -0.534782609 -0.554347826 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Sulfur metabolism -0.530434783 -0.503952569 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Synthesis and degradation of ketone bodies -0.493043478 -0.697628458 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Terpenoid backbone biosynthesis 0 -0.425889328 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway TGF-beta signaling pathway 0 -0.698616601 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Thiamine metabolism -0.445217391 -0.765810277 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Toll-like receptor signaling pathway 0.489565217 0.886363636 0.52998713 yes kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Tryptophan metabolism -0.543478261 -0.529644269 0 kegg kegg NA NA no no no no up no Fc epsilon RI signaling pathway Tyrosine metabolism -0.592173913 -0.757905138 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.528695652 -0.666996047 -0.424967825 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Ubiquitin mediated proteolysis 0 -0.678853755 -0.58996139 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway "Valine, leucine and isoleucine degradation" -0.612173913 -0.740118577 -0.40978121 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Various types of N-glycan biosynthesis 0 -0.650197628 0 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Vascular smooth muscle contraction 0 -0.604743083 -0.458429858 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway VEGF signaling pathway 0.829565217 0.65513834 0.50965251 kegg kegg NA NA no no no no no no Fc epsilon RI signaling pathway Wnt signaling pathway 0 -0.745059289 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis 2-Oxocarboxylic acid metabolism 0 -0.501976285 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Adrenergic signaling in cardiomyocytes -0.484347826 -0.71541502 -0.533590734 kegg kegg NA NA no no no no no up Fc gamma R-mediated phagocytosis "Alanine, aspartate and glutamate metabolism" 0.513913043 0.636363636 0.730759331 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis alpha-Linolenic acid metabolism 0.446086957 0.501976285 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Amino sugar and nucleotide sugar metabolism 0.405217391 0 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Aminoacyl-tRNA biosynthesis 0 -0.460474308 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis AMPK signaling pathway -0.642608696 -0.60770751 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Antifolate resistance 0 -0.47826087 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Antigen processing and presentation 0 0 0.513770914 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Apelin signaling pathway -0.487826087 -0.527667984 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Apoptosis 0.570434783 0.616600791 0.578120978 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Arginine and proline metabolism 0.584347826 0.673913043 0.513256113 kegg kegg NA NA no no no no up no Fc gamma R-mediated phagocytosis Arginine biosynthesis 0.613913043 0.677865613 0.763449163 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis B cell receptor signaling pathway 0 0.533596838 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Basal transcription factors 0 -0.577075099 -0.48005148 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Base excision repair 0 -0.508893281 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Biosynthesis of amino acids 0.60173913 0.871541502 0.818275418 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Biosynthesis of cofactors 0 -0.527667984 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis C-type lectin receptor signaling pathway 0 0.568181818 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Calcium signaling pathway -0.515652174 -0.596837945 -0.558558559 kegg kegg NA NA no no no no up up Fc gamma R-mediated phagocytosis Carbon metabolism 0.454782609 0.537549407 0.731788932 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Cardiac muscle contraction 0 -0.644268775 -0.483655084 kegg kegg NA NA no no no no no up Fc gamma R-mediated phagocytosis Cell adhesion molecules 0 0.640316206 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Cell cycle 0 -0.732213439 -0.6 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Cellular senescence 0 0.571146245 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis cGMP-PKG signaling pathway 0.531304348 0.89229249 0.506563707 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Chemokine signaling pathway 0 0.632411067 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Complement and coagulation cascades 0.57826087 0.852766798 0.712741313 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Cytokine-cytokine receptor interaction 0 0.601778656 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis DNA replication 0 -0.602766798 -0.433976834 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Drug metabolism - cytochrome P450 0 -0.510869565 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis EGFR tyrosine kinase inhibitor resistance -0.576521739 -0.495059289 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Endocrine resistance -0.569565217 -0.54743083 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Endocytosis 0.452173913 0.698616601 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Ether lipid metabolism -0.546956522 -0.579051383 -0.514543115 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Fanconi anemia pathway 0 -0.529644269 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Fatty acid biosynthesis 0.619130435 0.713438735 0.620849421 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Fatty acid degradation 0.672173913 0.610671937 0.481081081 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Fatty acid elongation 0.517391304 0 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Fatty acid metabolism 0.72 0.706521739 0.578120978 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Fc epsilon RI signaling pathway 0 0.72826087 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Folate biosynthesis 0 -0.502964427 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis FoxO signaling pathway 0.413913043 0 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Galactose metabolism 0.494782609 0.493083004 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Glutathione metabolism -0.477391304 -0.60770751 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Glycerolipid metabolism 0 0 -0.483912484 kegg kegg NA NA no no no no no up Fc gamma R-mediated phagocytosis Glycerophospholipid metabolism 0 0 -0.516344916 kegg kegg NA NA no no no no no up Fc gamma R-mediated phagocytosis "Glycine, serine and threonine metabolism" -0.471304348 -0.451581028 0 kegg kegg NA NA no no no no up no Fc gamma R-mediated phagocytosis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.450434783 0 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.403603604 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Glycosaminoglycan biosynthesis - keratan sulfate -0.526956522 -0.491106719 -0.464607465 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Glycosaminoglycan degradation 0.408695652 0.563241107 0 kegg kegg NA NA no no no no no up Fc gamma R-mediated phagocytosis Glycosphingolipid biosynthesis - ganglio series 0 -0.471343874 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.5 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Glyoxylate and dicarboxylate metabolism 0.569565217 0.707509881 0.771428571 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Hedgehog signaling pathway 0 -0.54743083 -0.664092664 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis HIF-1 signaling pathway -0.433913043 0 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Hippo signaling pathway - multiple species 0.456521739 0.486166008 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis IL-17 signaling pathway 0.673043478 0.850790514 0.718404118 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Inositol phosphate metabolism 0 0 -0.436550837 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Longevity regulating pathway -0.572173913 0 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Longevity regulating pathway - multiple species 0.484347826 0.423913043 0.414157014 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Lysine degradation -0.470434783 -0.611660079 -0.677992278 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Lysosome 0.577391304 0.833992095 0.657400257 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Mannose type O-glycan biosynthesis -0.526086957 -0.572134387 -0.726126126 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Mitophagy - animal -0.810434783 -0.617588933 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis mRNA surveillance pathway -0.546086957 -0.856719368 -0.779407979 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis mTOR signaling pathway -0.591304348 -0.491106719 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis N-Glycan biosynthesis 0 -0.697628458 -0.462033462 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Natural killer cell mediated cytotoxicity 0.413913043 0.644268775 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Necroptosis -0.570434783 0 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Neuroactive ligand-receptor interaction 0.762608696 0.92687747 0.836550837 kegg kegg NA NA no no no up up up Fc gamma R-mediated phagocytosis Neutrophil extracellular trap formation 0.85826087 0.935770751 0.821364221 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Nicotinate and nicotinamide metabolism 0.728695652 0.763833992 0.692406692 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Nitrogen metabolism 0.471304348 0.610671937 0.612870013 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis NOD-like receptor signaling pathway 0.765217391 0.639328063 0.592277992 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Notch signaling pathway 0 0 -0.44993565 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Nucleotide excision repair 0 -0.549407115 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Odoribacter 0 0.421001786 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Fc gamma R-mediated phagocytosis One carbon pool by folate 0 -0.559288538 -0.581981982 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Osteoclast differentiation 0.78 0.862648221 0.661776062 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Other types of O-glycan biosynthesis -0.42173913 -0.585968379 -0.586100386 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Oxidative phosphorylation 0 -0.612648221 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis p53 signaling pathway 0 0 -0.43989704 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Pantothenate and CoA biosynthesis 0.834782609 0.793478261 0.695495495 kegg kegg NA NA no no no no no dn Fc gamma R-mediated phagocytosis Paraprevotella 0 -0.461925874 0 kegg Genus NA 0.118 no no no no no no Fc gamma R-mediated phagocytosis Pentose and glucuronate interconversions 0 -0.577075099 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Pentose phosphate pathway 0.606086957 0.928853755 0.757528958 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Peroxisome 0.716521739 0.754940711 0.707850708 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Phagosome 0.46173913 0.778656126 0.525611326 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Phosphatidylinositol signaling system 0 0 -0.584041184 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Porphyrin and chlorophyll metabolism -0.449565217 -0.454545455 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis PPAR signaling pathway 0 0.693675889 0.55032175 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Primary bile acid biosynthesis 0 0 0.543371943 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Protein export -0.546086957 -0.551383399 -0.578893179 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Protein processing in endoplasmic reticulum -0.579130435 -0.818181818 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Purine metabolism -0.576521739 -0.578063241 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Pyrimidine metabolism 0 -0.470355731 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Pyruvate metabolism 0 -0.473320158 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Ras signaling pathway 0 -0.418972332 -0.467696268 yes kegg kegg NA NA no no no no up up Fc gamma R-mediated phagocytosis Renin-angiotensin system 0.797391304 0.880434783 0.658172458 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Retinol metabolism 0.462608696 0 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Ribosome -0.804347826 -0.562252964 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Ribosome biogenesis in eukaryotes -0.424347826 -0.682806324 -0.572715573 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis RIG-I-like receptor signaling pathway 0 0.42687747 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis RNA degradation -0.553043478 -0.805335968 -0.673873874 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis RNA polymerase -0.54 -0.802371542 -0.532561133 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis RNA transport 0 -0.418972332 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Ruminococcus -0.654782609 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Fc gamma R-mediated phagocytosis Signaling pathways regulating pluripotency of stem cells 0 -0.423913043 -0.475675676 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Sphingolipid signaling pathway 0 0.585968379 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Spliceosome 0 0 -0.48983269 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Starch and sucrose metabolism 0.715652174 0.686758893 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Taurine and hypotaurine metabolism 0 0 -0.604118404 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Tight junction 0 0 0.422651223 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Toll-like receptor signaling pathway 0 0.631422925 0 yes kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Ubiquitin mediated proteolysis -0.864347826 -0.732213439 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Various types of N-glycan biosynthesis 0 -0.545454545 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Vascular smooth muscle contraction -0.55826087 -0.424901186 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Viral protein interaction with cytokine and cytokine receptor 0 0.541501976 0 kegg kegg NA NA no no no no no no Fc gamma R-mediated phagocytosis Wnt signaling pathway 0 -0.760869565 -0.663063063 kegg kegg NA NA no no no no no no Ferroptosis 2-Oxocarboxylic acid metabolism 0 -0.57312253 -0.553153153 kegg kegg NA NA no no no no no no Ferroptosis ABC transporters -0.540869565 0 0 kegg kegg NA NA no no no no up up Ferroptosis Alistipes 0 -0.413572343 0 kegg Genus NA 0.0114 no no no no up no Ferroptosis alpha-Linolenic acid metabolism 0 0 -0.431402831 kegg kegg NA NA no no no no no no Ferroptosis Aminoacyl-tRNA biosynthesis -0.42 -0.500988142 -0.40952381 kegg kegg NA NA no no no no no no Ferroptosis AMPK signaling pathway 0 0 0.651222651 kegg kegg NA NA no no no no no no Ferroptosis Antifolate resistance 0 -0.431818182 0 kegg kegg NA NA no no no no no no Ferroptosis Arachidonic acid metabolism 0.409565217 0.450592885 0.571171171 kegg kegg NA NA no no no no no no Ferroptosis Arginine biosynthesis 0 0 0.410810811 kegg kegg NA NA no no no no no no Ferroptosis Ascorbate and aldarate metabolism 0 0 -0.427799228 kegg kegg NA NA no no no no no no Ferroptosis Autophagy - other 0 0 -0.434749035 kegg kegg NA NA no no no no no no Ferroptosis Base excision repair -0.44 -0.467391304 0 kegg kegg NA NA no no no no no no Ferroptosis beta-Alanine metabolism 0 -0.522727273 0 kegg kegg NA NA no no no no no no Ferroptosis Biosynthesis of cofactors 0 0 0.613127413 kegg kegg NA NA no no no no no no Ferroptosis Biosynthesis of unsaturated fatty acids -0.486956522 -0.54743083 0 kegg kegg NA NA no no no no no no Ferroptosis Butanoate metabolism 0 -0.591897233 0 kegg kegg NA NA no no no no no no Ferroptosis cAMP signaling pathway 0 0.59486166 0 yes kegg kegg NA NA no no no no up up Ferroptosis Carbon metabolism 0 -0.418972332 0 kegg kegg NA NA no no no no no no Ferroptosis Cell cycle -0.474782609 -0.420948617 -0.533848134 kegg kegg NA NA no no no no no no Ferroptosis Citrate cycle (TCA cycle) -0.437391304 -0.577075099 -0.45997426 kegg kegg NA NA no no no no no no Ferroptosis Cysteine and methionine metabolism 0 -0.464426877 0 kegg kegg NA NA no no no no no no Ferroptosis DNA replication -0.52 -0.54743083 0 kegg kegg NA NA no no no no no no Ferroptosis ErbB signaling pathway 0 0 -0.646846847 kegg kegg NA NA no no no no no no Ferroptosis Fanconi anemia pathway -0.545217391 0 -0.490862291 kegg kegg NA NA no no no no no no Ferroptosis Fatty acid elongation 0 -0.533596838 0 kegg kegg NA NA no no no no no no Ferroptosis Folate biosynthesis -0.448695652 0 0 kegg kegg NA NA no no no no no no Ferroptosis Glutathione metabolism 0.483478261 0 0.656113256 kegg kegg NA NA no no no no no no Ferroptosis Glycerolipid metabolism 0 0 -0.665379665 kegg kegg NA NA no no no no no up Ferroptosis Glycerophospholipid metabolism 0 0 -0.554440154 kegg kegg NA NA no no no no no up Ferroptosis "Glycine, serine and threonine metabolism" 0 0 0.635263835 kegg kegg NA NA no no no no up no Ferroptosis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.511857708 -0.557271557 kegg kegg NA NA no no no no no no Ferroptosis Glycosaminoglycan degradation 0 0 -0.503732304 kegg kegg NA NA no no no no no up Ferroptosis Glycosphingolipid biosynthesis - ganglio series 0 -0.564229249 0 kegg kegg NA NA no no no no no no Ferroptosis Glycosphingolipid biosynthesis - globo and isoglobo series 0.439130435 0 0 kegg kegg NA NA no no no no no no Ferroptosis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.493913043 0 0 kegg kegg NA NA no no no no no no Ferroptosis Homologous recombination -0.531304348 0 0 kegg kegg NA NA no no no no no no Ferroptosis Inositol phosphate metabolism -0.643478261 0 -0.61003861 kegg kegg NA NA no no no no no no Ferroptosis Longevity regulating pathway 0.427826087 0 0.657657658 kegg kegg NA NA no no no no no no Ferroptosis Longevity regulating pathway - multiple species -0.455652174 -0.52173913 0 kegg kegg NA NA no no no no no no Ferroptosis Lysine degradation 0 0 -0.564993565 kegg kegg NA NA no no no no no no Ferroptosis Mannose type O-glycan biosynthesis 0 0 -0.540540541 kegg kegg NA NA no no no no no no Ferroptosis MAPK signaling pathway 0 0 -0.539253539 kegg kegg NA NA no no no no no no Ferroptosis Metabolism of xenobiotics by cytochrome P450 0 -0.444664032 0 kegg kegg NA NA no no no no no no Ferroptosis Mismatch repair -0.47826087 -0.467391304 0 kegg kegg NA NA no no no no no no Ferroptosis Mitophagy - animal 0.651304348 0.420948617 0.756241956 kegg kegg NA NA no no no no no no Ferroptosis mRNA surveillance pathway 0 0 -0.411583012 kegg kegg NA NA no no no no no no Ferroptosis Mucin type O-glycan biosynthesis 0 -0.513833992 0 kegg kegg NA NA no no no no no no Ferroptosis N-Glycan biosynthesis -0.444347826 -0.448616601 -0.605405405 kegg kegg NA NA no no no no no no Ferroptosis NF-kappa B signaling pathway -0.55826087 0 0 kegg kegg NA NA no no no no no no Ferroptosis Nitrogen metabolism 0 0.416007905 0.465894466 kegg kegg NA NA no no no no no no Ferroptosis Non-homologous end-joining -0.43826087 -0.567193676 0 kegg kegg NA NA no no no no no no Ferroptosis Nucleotide excision repair -0.527826087 -0.52173913 0 kegg kegg NA NA no no no no no no Ferroptosis Odoribacter 0 -0.459139595 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Ferroptosis One carbon pool by folate -0.437391304 -0.482213439 -0.496267696 kegg kegg NA NA no no no no no no Ferroptosis Oocyte meiosis 0 -0.556324111 -0.461003861 kegg kegg NA NA no no no no no no Ferroptosis Other glycan degradation 0 0 -0.696267696 kegg kegg NA NA no no no no no no Ferroptosis Other types of O-glycan biosynthesis 0 0 -0.601287001 kegg kegg NA NA no no no no no no Ferroptosis Pentose and glucuronate interconversions 0 -0.527667984 -0.52972973 kegg kegg NA NA no no no no no no Ferroptosis Phenylalanine metabolism 0 -0.542490119 0 kegg kegg NA NA no no no no no no Ferroptosis Phosphatidylinositol signaling system 0 -0.625494071 -0.595881596 kegg kegg NA NA no no no no no no Ferroptosis Phospholipase D signaling pathway 0 0.419960474 0 kegg kegg NA NA no no no no up up Ferroptosis Platinum drug resistance 0 0 -0.423166023 kegg kegg NA NA no no no no no no Ferroptosis Porphyrin and chlorophyll metabolism 0 0 0.688545689 kegg kegg NA NA no no no no no no Ferroptosis Primary bile acid biosynthesis -0.503478261 -0.531620553 0 kegg kegg NA NA no no no no no no Ferroptosis Propanoate metabolism 0 -0.425889328 0 kegg kegg NA NA no no no no no no Ferroptosis Purine metabolism 0 0 0.792020592 kegg kegg NA NA no no no no no no Ferroptosis Pyrimidine metabolism 0 -0.414031621 0 kegg kegg NA NA no no no no no no Ferroptosis Ras signaling pathway 0 -0.427865613 -0.451737452 yes kegg kegg NA NA no no no no up up Ferroptosis Retinol metabolism 0 -0.614624506 -0.457657658 kegg kegg NA NA no no no no no no Ferroptosis Ribosome biogenesis in eukaryotes 0 -0.441699605 -0.548519949 kegg kegg NA NA no no no no no no Ferroptosis RNA degradation 0 0 -0.580694981 kegg kegg NA NA no no no no no no Ferroptosis Selenocompound metabolism 0 0 -0.540797941 kegg kegg NA NA no no no no no no Ferroptosis SNARE interactions in vesicular transport -0.423478261 0 0 kegg kegg NA NA no no no no no no Ferroptosis Sphingolipid signaling pathway 0 0 -0.57014157 kegg kegg NA NA no no no no no no Ferroptosis Spliceosome 0 0 -0.520720721 kegg kegg NA NA no no no no no no Ferroptosis Steroid biosynthesis 0 -0.510869565 0 kegg kegg NA NA no no no no no no Ferroptosis Steroid hormone biosynthesis 0 -0.415019763 0 kegg kegg NA NA no no no no no no Ferroptosis Sulfur metabolism 0 0 0.55984556 kegg kegg NA NA no no no no no no Ferroptosis Synthesis and degradation of ketone bodies -0.409565217 -0.603754941 0 kegg kegg NA NA no no no no no no Ferroptosis Terpenoid backbone biosynthesis 0 -0.556324111 -0.437065637 kegg kegg NA NA no no no no no no Ferroptosis Tryptophan metabolism -0.412173913 -0.662055336 0 kegg kegg NA NA no no no no up no Ferroptosis Tyrosine metabolism 0 -0.424901186 0 kegg kegg NA NA no no no no no no Ferroptosis Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.602766798 0 kegg kegg NA NA no no no no no no Ferroptosis Ubiquitin mediated proteolysis 0.520869565 0 0.738996139 kegg kegg NA NA no no no no no no Ferroptosis "Valine, leucine and isoleucine degradation" -0.472173913 -0.580039526 0 kegg kegg NA NA no no no no no no Ferroptosis Various types of N-glycan biosynthesis 0 -0.583003953 -0.728442728 kegg kegg NA NA no no no no no no FGF basic 16:0/18:2-PI+blood 0 0 -0.562406015 serum_cytokines serum_phospholipids 0.65 0.269 no no no no no no FGF basic 16:0/22:6-PC+blood -0.672727273 0 0 serum_cytokines serum_phospholipids 0.65 4.53E-05 no no no no up up FGF basic 16:1/16:1-PC+blood 0 -0.564285714 0 serum_cytokines serum_phospholipids 0.65 0.0177 no no no no no up FGF basic 18:0-LPC+blood 0 0 -0.466165414 serum_cytokines serum_phospholipids 0.65 0.554 no no no no no no FGF basic 18:1/18:1-PC+blood 0 0.542857143 0 serum_cytokines serum_phospholipids 0.65 1.34E-05 no no no no up up FGF basic 18:3n3+blood 0 -0.628571429 0 serum_cytokines serum_fattyacid 0.65 0.291 no no no no no no FGF basic 20:0+blood 0.660606061 0 -0.717293233 yes serum_cytokines serum_fattyacid 0.65 0.000278 no no no dn no up FGF basic 4-hydroxy-3-methoxymandelic acid+urine 0 0.5 0 serum_cytokines urine_cometabolism 0.65 0.973 no no no no no no FGF basic AA+blood -0.696969697 0 0 serum_cytokines serum_ARA 0.65 0.212 no no no no no no FGF basic Acute myeloid leukemia 0 0.572932331 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Adipocytokine signaling pathway 0 0 -0.406130268 serum_cytokines kegg 0.65 NA no no no no no no FGF basic AGE-RAGE signaling pathway in diabetic complications -0.593406593 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Aldosterone synthesis and secretion 0 0 -0.402298851 serum_cytokines kegg 0.65 NA no no no no up up FGF basic Allograft rejection -0.78021978 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Alzheimer disease 0.796703297 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Amoebiasis 0 0.458646617 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Amyotrophic lateral sclerosis 0.840659341 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Apoptosis 0 0.518796992 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Arrhythmogenic right ventricular cardiomyopathy 0 0 0.444444444 serum_cytokines kegg 0.65 NA no no no no up up FGF basic Autoimmune thyroid disease -0.78021978 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Axon guidance 0 0.544360902 0 serum_cytokines kegg 0.65 NA no no no no up up FGF basic B cell receptor signaling pathway 0 0.455639098 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Bacterial invasion of epithelial cells 0 0 0.48166393 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Bacteroides -0.642857143 0 0 LPS-producing serum_cytokines Genus 0.65 0.000267 no no no dn dn up FGF basic Bifidobacterium 0 0 -0.450774061 acetate-producing serum_cytokines Genus 0.65 0.105 no no no no dn no FGF basic Biosynthesis of amino acids -0.648351648 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Biosynthesis of cofactors 0 -0.523308271 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic C-type lectin receptor signaling pathway 0 0 -0.469622332 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Calcium signaling pathway 0 0 -0.436781609 serum_cytokines kegg 0.65 NA no no no no up up FGF basic cAMP signaling pathway 0 0.478195489 -0.51833607 yes serum_cytokines kegg 0.65 NA no no no no up up FGF basic Carbon metabolism 0 0 0.452654625 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Cardiac muscle contraction 0.835164835 0 0 serum_cytokines kegg 0.65 NA no no no no no up FGF basic Cell adhesion molecules -0.741758242 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Cellular senescence -0.642857143 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Chagas disease 0 0.481203008 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Chemical carcinogenesis - receptor activation 0 0 -0.484400657 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Chronic myeloid leukemia 0 0.606015038 -0.497536946 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Cocaine addiction 0 0 -0.408866995 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Cortisol synthesis and secretion 0 0 -0.417624521 serum_cytokines kegg 0.65 NA no no no no no up FGF basic Cytosolic DNA-sensing pathway 0 0.502255639 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic d18:1-22:0-SM+blood 0.721212121 0 0 serum_cytokines serum_phospholipids 0.65 0.522 no no no no no no FGF basic Diabetic cardiomyopathy 0.851648352 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Endocytosis -0.708791209 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Estrogen signaling pathway 0 -0.448120301 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Fc epsilon RI signaling pathway 0 0.45112782 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Focal adhesion 0 0 0.578544061 serum_cytokines kegg 0.65 NA no no no no up up FGF basic GCA+blood 0 0 0.472180451 yes serum_cytokines serum_bileacids 0.65 0.16 no no no no no no FGF basic Glycolysis / Gluconeogenesis 0 0 0.48166393 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Graft-versus-host disease -0.758241758 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic "Growth hormone synthesis, secretion and action" 0 0 -0.47454844 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Hepatitis B 0 0 -0.406130268 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Hepatitis C 0 0.493233083 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Hippo signaling pathway 0 0 0.524356869 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Human papillomavirus infection -0.741758242 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Huntington disease 0.846153846 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Hypertrophic cardiomyopathy 0 0 0.451559934 serum_cytokines kegg 0.65 NA no no no no up up FGF basic Insulin resistance 0 0 -0.629994527 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Insulin secretion 0 0 -0.449370553 yes serum_cytokines kegg 0.65 NA no no no no up up FGF basic L-Alanine+blood 0 0 -0.464661654 yes serum_cytokines serum_aminoacids 0.65 0.00138 no no no up up no FGF basic L-Homocystine+blood 0.648484848 0 0 serum_cytokines serum_aminoacids 0.65 0.197 no no no no no no FGF basic L-Tryptophan+urine 0.672727273 0 0 serum_cytokines urine_cometabolism 0.65 0.226 no no no no no no FGF basic Leukocyte transendothelial migration 0 0 0.474001095 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Longevity regulating pathway - multiple species 0 0 0.405582923 serum_cytokines kegg 0.65 NA no no no no no no FGF basic mRNA surveillance pathway 0.67032967 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic n3+blood 0 -0.514285714 0 serum_cytokines serum_fattyacid 0.65 0.806 no no no no no no FGF basic Natural killer cell mediated cytotoxicity -0.615384615 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Neurotrophin signaling pathway 0 0.587969925 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic NF-kappa B signaling pathway 0 0 -0.528188287 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Non-alcoholic fatty liver disease 0.747252747 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Oxidative phosphorylation 0.868131868 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic P-hydroxyhippuric acid+urine -0.636363636 0 0 serum_cytokines urine_cometabolism 0.65 0.436 no no no no no no FGF basic "Parathyroid hormone synthesis, secretion and action" 0 0 -0.515599343 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Parkinson disease 0.653846154 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Pathways of neurodegeneration - multiple diseases 0.653846154 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Phagosome -0.747252747 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Primary immunodeficiency 0 -0.481203008 0.496442255 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Prion disease 0.835164835 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Prostate cancer 0 0.544360902 -0.556102901 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Regulation of actin cytoskeleton 0 0 0.42364532 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Relaxin signaling pathway 0 0.488721805 -0.571975917 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Retrograde endocannabinoid signaling 0.774725275 0 0 serum_cytokines kegg 0.65 NA no no no no no up FGF basic Rheumatoid arthritis 0 0 0.562671045 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Ribosome biogenesis in eukaryotes 0 -0.473684211 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic RIG-I-like receptor signaling pathway 0 0 -0.48877942 serum_cytokines kegg 0.65 NA no no no no no no FGF basic RNA degradation 0.631868132 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Ruminococcus 0 0 -0.401896275 serum_cytokines Genus 0.65 0.0679 no no no no no dn FGF basic Salmonella infection 0 0 0.4969896 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Sarcina 0 0.458682472 0 serum_cytokines Genus 0.65 0.0703 no no no no no no FGF basic Sarcosine+blood 0 0 -0.455639098 serum_cytokines serum_choline 0.65 5.06E-05 no no no up up no FGF basic Small cell lung cancer 0 0.454135338 -0.65681445 serum_cytokines kegg 0.65 NA no no no no no up FGF basic Sphingolipid signaling pathway 0 0.530827068 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic TCA+blood 0 0 0.449941231 serum_cytokines serum_bileacids 0.65 0.339 no no no no no no FGF basic Thermogenesis 0.758241758 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Tight junction 0 0 0.425834702 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Transcriptional misregulation in cancer 0 0 -0.528735632 serum_cytokines kegg 0.65 NA no no no no no no FGF basic TXB2+blood -0.911858316 0 0 yes serum_cytokines serum_ARA 0.65 0.0644 no no no dn no no FGF basic Type I diabetes mellitus -0.78021978 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Viral carcinogenesis -0.587912088 0 0 serum_cytokines kegg 0.65 NA no no no no no no FGF basic Viral myocarditis -0.752747253 0 0 serum_cytokines kegg 0.65 NA no no no no no no Finegoldia Corynebacterium 0 0.400240341 0 Genus Genus 0.456 0.216 no no no no no no Finegoldia Eggerthella 0 0.468989962 0 Genus Genus 0.456 0.912 no no no no no no Fluid shear stress and atherosclerosis ABC transporters 0 -0.62055336 0 kegg kegg NA NA no no no no up up Fluid shear stress and atherosclerosis Adherens junction 0.833043478 0.774703557 0.836808237 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Adipocytokine signaling pathway 0 -0.511857708 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis AMPK signaling pathway 0 -0.453557312 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Anaerostipes 0 -0.483052842 0 butyrate-producing kegg Genus NA 0.568 no no no no no no Fluid shear stress and atherosclerosis Apelin signaling pathway -0.42173913 0 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Apoptosis 0.540869565 0 0.70990991 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Apoptosis - multiple species -0.682608696 -0.662055336 -0.404118404 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Arrhythmogenic right ventricular cardiomyopathy 0.771304348 0.714426877 0.818790219 kegg kegg NA NA no no no no up up Fluid shear stress and atherosclerosis Asthma 0 0.503952569 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Autophagy - animal -0.433913043 -0.579051383 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Autophagy - other -0.64173913 -0.825098814 -0.679279279 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Bacterial invasion of epithelial cells 0.802608696 0.877470356 0.823680824 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Basal cell carcinoma 0 -0.528656126 -0.542857143 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Basal transcription factors -0.573043478 0 -0.606177606 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Base excision repair -0.669565217 -0.4743083 -0.47027027 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis beta-Alanine metabolism 0 0.509881423 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Biosynthesis of amino acids 0 0 0.496525097 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Breast cancer 0 -0.519762846 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Butyricicoccus -0.518542838 0 0 butyrate-producing kegg Genus NA 0.852 no no no no no no Fluid shear stress and atherosclerosis Carbohydrate digestion and absorption 0 -0.420948617 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Carbon metabolism 0 0.70256917 0.547490347 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Cell adhesion molecules 0 0 0.42985843 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Cell cycle 0 0 -0.473101673 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Chemical carcinogenesis - DNA adducts 0 0 0.528700129 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Chemical carcinogenesis - receptor activation 0 -0.461462451 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Chemokine signaling pathway 0 0 0.447361647 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Choline metabolism in cancer 0 -0.460474308 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Chronic myeloid leukemia -0.428695652 -0.43083004 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Circadian entrainment 0.48173913 0.495059289 0 kegg kegg NA NA no no no no up up Fluid shear stress and atherosclerosis Circadian rhythm 0 -0.566205534 -0.672329472 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Clostridium 0 0.42993591 0 kegg Genus NA 0.925 no no no no no no Fluid shear stress and atherosclerosis Collecting duct acid secretion 0.497391304 0.513833992 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Complement and coagulation cascades 0 0 0.586100386 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Cushing syndrome 0 -0.493083004 -0.44015444 kegg kegg NA NA no no no no no up Fluid shear stress and atherosclerosis Cytokine-cytokine receptor interaction 0 0 0.529214929 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Dilated cardiomyopathy 0.746086957 0.650197628 0.641441441 kegg kegg NA NA no no no no up up Fluid shear stress and atherosclerosis Drug metabolism - other enzymes 0 0.421936759 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis EGFR tyrosine kinase inhibitor resistance -0.55826087 0 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Endometrial cancer 0 -0.519762846 -0.455341055 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis ErbB signaling pathway 0 -0.540513834 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Eubacterium 0 0 -0.407286627 kegg Genus NA 0.0692 no no no no no no Fluid shear stress and atherosclerosis Fanconi anemia pathway 0 0 -0.42960103 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Fatty acid elongation 0 0.462450593 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Focal adhesion 0.776521739 0.796442688 0.709395109 kegg kegg NA NA no no no no up up Fluid shear stress and atherosclerosis FoxO signaling pathway 0 -0.506916996 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Gastric acid secretion 0.820869565 0.68972332 0.754954955 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Gastric cancer 0 -0.586956522 -0.467953668 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Glucagon signaling pathway 0 0 -0.574774775 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Glycerolipid metabolism 0 -0.518774704 0 kegg kegg NA NA no no no no no up Fluid shear stress and atherosclerosis Glycerophospholipid metabolism 0 -0.614624506 0 kegg kegg NA NA no no no no no up Fluid shear stress and atherosclerosis Glycolysis / Gluconeogenesis 0 0.488142292 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Glycosaminoglycan degradation 0.405217391 0 0 kegg kegg NA NA no no no no no up Fluid shear stress and atherosclerosis Glycosphingolipid biosynthesis - globo and isoglobo series 0.454782609 0 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.410434783 -0.470355731 -0.417245817 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis GnRH secretion 0 -0.532608696 0 kegg kegg NA NA no no no no up up Fluid shear stress and atherosclerosis "Growth hormone synthesis, secretion and action" 0 -0.436758893 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Hematopoietic cell lineage 0 0.464426877 0.471299871 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Hepatitis B 0 -0.500988142 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Hepatocellular carcinoma 0.779130435 0.678853755 0.742342342 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis HIF-1 signaling pathway -0.59826087 0 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Hippo signaling pathway 0.730434783 0.627470356 0.665637066 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Histidine metabolism 0 0 0.432689833 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Homologous recombination 0 -0.585968379 -0.482882883 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Hypertrophic cardiomyopathy 0.740869565 0.785573123 0.835263835 kegg kegg NA NA no no no no up up Fluid shear stress and atherosclerosis Influenza A 0.444347826 0.463438735 0.82033462 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Inositol phosphate metabolism 0 -0.513833992 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Insulin resistance -0.495652174 -0.505928854 -0.564993565 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Insulin signaling pathway -0.500869565 0 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis JAK-STAT signaling pathway 0 -0.5256917 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Lachnospira 0 0.691376349 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Fluid shear stress and atherosclerosis Leukocyte transendothelial migration 0.728695652 0.78458498 0.792535393 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Long-term potentiation 0 0 -0.445302445 kegg kegg NA NA no no no no no up Fluid shear stress and atherosclerosis Longevity regulating pathway 0 -0.650197628 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Lysine degradation -0.676521739 -0.635375494 -0.456885457 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Lysosome 0 0.479249012 0.460746461 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Mannose type O-glycan biosynthesis 0 -0.528656126 -0.423423423 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Melanoma 0 -0.4743083 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Metabolism of xenobiotics by cytochrome P450 0 0 0.401544402 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis MicroRNAs in cancer 0 -0.563241107 -0.413127413 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis mRNA surveillance pathway 0 0 -0.550579151 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis mTOR signaling pathway -0.537391304 0 -0.45045045 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Mucin type O-glycan biosynthesis 0 -0.505928854 -0.428828829 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Neuroactive ligand-receptor interaction 0.437391304 0.43083004 0.430630631 kegg kegg NA NA no no no up up up Fluid shear stress and atherosclerosis Neutrophil extracellular trap formation 0.479130435 0.450592885 0.676705277 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis NF-kappa B signaling pathway 0 -0.4743083 -0.402831403 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Nicotine addiction 0 -0.504940711 0 kegg kegg NA NA no no no no up up Fluid shear stress and atherosclerosis Non-small cell lung cancer 0 -0.53458498 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Other glycan degradation 0 -0.42687747 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Other types of O-glycan biosynthesis -0.55826087 -0.668972332 -0.496010296 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Oxytocin signaling pathway 0.848695652 0.885375494 0.705019305 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis p53 signaling pathway -0.693043478 -0.772727273 -0.635263835 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Pathogenic Escherichia coli infection 0.486956522 0.540513834 0.808751609 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Pathways in cancer 0 -0.530632411 -0.607722008 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 -0.497035573 -0.48957529 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Pentose phosphate pathway 0 0.472332016 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Pertussis 0 0 0.458944659 kegg kegg NA NA no no no no no dn Fluid shear stress and atherosclerosis Phagosome 0 0.488142292 0.645302445 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Phenylalanine metabolism 0.439130435 0.531620553 0.482110682 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Phosphatidylinositol signaling system 0 0 -0.416473616 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Phototransduction 0 0.574110672 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis PI3K-Akt signaling pathway 0 0 -0.423680824 yes kegg kegg NA NA no no no no up up Fluid shear stress and atherosclerosis Platelet activation 0.873043478 0.830039526 0.783268983 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Platinum drug resistance -0.662608696 -0.671936759 -0.435263835 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Primary bile acid biosynthesis 0 0.451581028 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Progesterone-mediated oocyte maturation 0 -0.583992095 -0.407464607 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Prostate cancer 0 -0.455533597 -0.441441441 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Protein export -0.448695652 0 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Protein processing in endoplasmic reticulum 0 0 -0.42985843 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Rap1 signaling pathway 0.853043478 0.813241107 0.798455598 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Regulation of actin cytoskeleton 0.64 0.675889328 0.491634492 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Renal cell carcinoma 0 0 -0.598970399 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Rheumatoid arthritis 0 0 0.574002574 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Ribosome biogenesis in eukaryotes -0.607826087 0 -0.466924067 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis RIG-I-like receptor signaling pathway -0.42 -0.507905138 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis RNA degradation 0 0 -0.476962677 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis RNA polymerase -0.696521739 0 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis RNA transport -0.51826087 0 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Roseburia 0.439130435 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no Fluid shear stress and atherosclerosis Salivary secretion 0 0.585968379 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Salmonella infection 0 0.507905138 0.712741313 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Selenocompound metabolism -0.609565217 -0.506916996 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Serotonergic synapse 0.5 0 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Signaling pathways regulating pluripotency of stem cells 0 -0.690711462 -0.465637066 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Small cell lung cancer -0.587826087 -0.522727273 -0.578893179 kegg kegg NA NA no no no no no up Fluid shear stress and atherosclerosis SNARE interactions in vesicular transport 0 -0.5256917 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Sphingolipid metabolism 0.413043478 0 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Spinocerebellar ataxia -0.609565217 0 -0.407722008 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Spliceosome -0.724347826 -0.785573123 -0.622136422 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Staphylococcus aureus infection 0 0.4743083 0.601544402 kegg kegg NA NA no no no up no no Fluid shear stress and atherosclerosis Synaptic vesicle cycle 0.459130435 0.469367589 0.414157014 kegg kegg NA NA no no no no up up Fluid shear stress and atherosclerosis Systemic lupus erythematosus 0 0.429841897 0.457915058 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis T cell receptor signaling pathway 0 -0.609683794 -0.534105534 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Taurine and hypotaurine metabolism 0 -0.649209486 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Thyroid hormone signaling pathway 0.74173913 0.596837945 0.672586873 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Tight junction 0.709565217 0.785573123 0.744658945 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Transcriptional misregulation in cancer -0.604347826 -0.592885375 -0.625482625 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Tuberculosis 0 0 0.615444015 kegg kegg NA NA no no no no no dn Fluid shear stress and atherosclerosis Type II diabetes mellitus 0 -0.557312253 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Various types of N-glycan biosynthesis -0.439130435 0 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Vibrio cholerae infection 0.854782609 0.732213439 0.81981982 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Viral myocarditis 0 0.428853755 0.545688546 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Viral protein interaction with cytokine and cytokine receptor 0 0.415019763 0 kegg kegg NA NA no no no no no no Fluid shear stress and atherosclerosis Yersinia infection 0.715652174 0.540513834 0.796396396 kegg kegg NA NA no no no no no no Focal adhesion 2-Oxocarboxylic acid metabolism 0 0.513833992 0 kegg kegg NA NA no up up no no no Focal adhesion ABC transporters 0 -0.625494071 0 kegg kegg NA NA no up up no up up Focal adhesion "Alanine, aspartate and glutamate metabolism" -0.409565217 -0.65513834 0 kegg kegg NA NA no up up no no no Focal adhesion Apelin signaling pathway -0.408695652 0.497035573 0 kegg kegg NA NA no up up no no no Focal adhesion Apoptosis 0.476521739 0 0 kegg kegg NA NA no up up no no no Focal adhesion Apoptosis - multiple species -0.559130435 -0.633399209 0 kegg kegg NA NA no up up no no no Focal adhesion Arginine and proline metabolism 0 -0.543478261 -0.405662806 kegg kegg NA NA no up up no up no Focal adhesion Arginine biosynthesis 0 -0.579051383 0 kegg kegg NA NA no up up no no no Focal adhesion Ascorbate and aldarate metabolism 0 0.436758893 0 kegg kegg NA NA no up up no no no Focal adhesion Autophagy - animal -0.709565217 -0.878458498 0 kegg kegg NA NA no up up no no no Focal adhesion Autophagy - other -0.770434783 -0.787549407 0 kegg kegg NA NA no up up no no no Focal adhesion Basal transcription factors -0.606956522 0 0 kegg kegg NA NA no up up no no no Focal adhesion Base excision repair -0.453043478 0 0 kegg kegg NA NA no up up no no no Focal adhesion beta-Alanine metabolism 0 0.572134387 0 kegg kegg NA NA no up up no no no Focal adhesion Bifidobacterium 0 0.44675719 0 acetate-producing kegg Genus NA 0.105 no up up no dn no Focal adhesion Biosynthesis of unsaturated fatty acids 0 0 0.456885457 kegg kegg NA NA no up up no no no Focal adhesion Butanoate metabolism 0 0.577075099 0 kegg kegg NA NA no up up no no no Focal adhesion Butyricicoccus -0.48173604 0 0 butyrate-producing kegg Genus NA 0.852 no up up no no no Focal adhesion Carbon metabolism 0.43826087 0.604743083 0 kegg kegg NA NA no up up no no no Focal adhesion Cardiac muscle contraction 0 0.530632411 0.502187902 kegg kegg NA NA no up up no no up Focal adhesion Citrate cycle (TCA cycle) 0 0.583992095 0 kegg kegg NA NA no up up no no no Focal adhesion Clostridium 0 0.439105159 0 kegg Genus NA 0.925 no up up no no no Focal adhesion Cysteine and methionine metabolism 0 0.514822134 0 kegg kegg NA NA no up up no no no Focal adhesion Cytokine-cytokine receptor interaction 0 0 0.633204633 kegg kegg NA NA no up up no no no Focal adhesion DNA replication 0 0.416007905 0 kegg kegg NA NA no up up no no no Focal adhesion Drug metabolism - cytochrome P450 0 0.673913043 0 kegg kegg NA NA no up up no no no Focal adhesion Drug metabolism - other enzymes 0 0.803359684 0 kegg kegg NA NA no up up no no no Focal adhesion EGFR tyrosine kinase inhibitor resistance -0.460869565 0 0 kegg kegg NA NA no up up no no no Focal adhesion ErbB signaling pathway 0 -0.615612648 0 kegg kegg NA NA no up up no no no Focal adhesion Fatty acid biosynthesis 0 -0.56027668 0 kegg kegg NA NA no up up no no no Focal adhesion Fatty acid degradation 0 -0.48715415 0 kegg kegg NA NA no up up no no no Focal adhesion Fatty acid elongation 0.431304348 0.555335968 0 kegg kegg NA NA no up up no no no Focal adhesion FoxO signaling pathway 0 -0.721343874 0 kegg kegg NA NA no up up no no no Focal adhesion Fructose and mannose metabolism 0 -0.45256917 0 kegg kegg NA NA no up up no no no Focal adhesion Glycerolipid metabolism 0 -0.648221344 0 kegg kegg NA NA no up up no no up Focal adhesion Glycerophospholipid metabolism -0.590434783 -0.707509881 0 kegg kegg NA NA no up up no no up Focal adhesion Glycolysis / Gluconeogenesis 0 0.72826087 0 kegg kegg NA NA no up up no no no Focal adhesion Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.711462451 0 kegg kegg NA NA no up up no no no Focal adhesion Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.614782609 0 0 kegg kegg NA NA no up up no no no Focal adhesion Glyoxylate and dicarboxylate metabolism 0 -0.570158103 0 kegg kegg NA NA no up up no no no Focal adhesion HIF-1 signaling pathway -0.527826087 0.479249012 0 kegg kegg NA NA no up up no no no Focal adhesion Hippo signaling pathway 0.910434783 0.914031621 0.958558559 kegg kegg NA NA no up up no no no Focal adhesion Hippo signaling pathway - multiple species 0 -0.493083004 0 kegg kegg NA NA no up up no no no Focal adhesion Homologous recombination 0 -0.490118577 0 kegg kegg NA NA no up up no no no Focal adhesion Inositol phosphate metabolism 0 -0.60770751 0 kegg kegg NA NA no up up no no no Focal adhesion Lachnospira 0 0.565851265 0 butyrate-producing kegg Genus NA 0.279 no up up no no no Focal adhesion Longevity regulating pathway -0.410434783 -0.615612648 0 kegg kegg NA NA no up up no no no Focal adhesion Lysine degradation -0.479130435 0 0 kegg kegg NA NA no up up no no no Focal adhesion MAPK signaling pathway 0 -0.553359684 0 kegg kegg NA NA no up up no no no Focal adhesion Metabolism of xenobiotics by cytochrome P450 0 0.735177866 0 kegg kegg NA NA no up up no no no Focal adhesion Mitophagy - animal 0 0 -0.424967825 kegg kegg NA NA no up up no no no Focal adhesion mRNA surveillance pathway -0.459130435 0 0 kegg kegg NA NA no up up no no no Focal adhesion mTOR signaling pathway -0.445217391 0 0 kegg kegg NA NA no up up no no no Focal adhesion Mucin type O-glycan biosynthesis 0 -0.508893281 0 kegg kegg NA NA no up up no no no Focal adhesion N-Glycan biosynthesis 0 0.467391304 0 kegg kegg NA NA no up up no no no Focal adhesion NF-kappa B signaling pathway -0.410434783 -0.77173913 -0.664607465 kegg kegg NA NA no up up no no no Focal adhesion Nicotinate and nicotinamide metabolism 0 -0.516798419 0 kegg kegg NA NA no up up no no no Focal adhesion Nitrogen metabolism 0 -0.592885375 0 kegg kegg NA NA no up up no no no Focal adhesion Non-homologous end-joining 0 0.536561265 0 kegg kegg NA NA no up up no no no Focal adhesion Notch signaling pathway 0 -0.492094862 0 kegg kegg NA NA no up up no no no Focal adhesion Oocyte meiosis 0 0.545454545 0 kegg kegg NA NA no up up no no no Focal adhesion Oscillospira 0 -0.41798419 0 LPS-producing kegg Genus NA 0.62 no up up no no no Focal adhesion Other glycan degradation 0 -0.502964427 0 kegg kegg NA NA no up up no no no Focal adhesion Other types of O-glycan biosynthesis -0.554782609 -0.47826087 0 kegg kegg NA NA no up up no no no Focal adhesion Oxidative phosphorylation 0 0.544466403 0.478507079 kegg kegg NA NA no up up no no no Focal adhesion p53 signaling pathway -0.705217391 -0.72826087 0 kegg kegg NA NA no up up no no no Focal adhesion Pantothenate and CoA biosynthesis 0 -0.434782609 0 kegg kegg NA NA no up up no no dn Focal adhesion Pentose and glucuronate interconversions 0 0.539525692 0 kegg kegg NA NA no up up no no no Focal adhesion Peroxisome 0 -0.481225296 0 kegg kegg NA NA no up up no no no Focal adhesion Phagosome 0.466956522 0 0 kegg kegg NA NA no up up no no no Focal adhesion Phenylalanine metabolism 0.653913043 0.716403162 0.506563707 kegg kegg NA NA no up up no no no Focal adhesion Phospholipase D signaling pathway 0 -0.585968379 0 kegg kegg NA NA no up up no up up Focal adhesion Platinum drug resistance -0.553043478 -0.586956522 0 kegg kegg NA NA no up up no no no Focal adhesion PPAR signaling pathway 0 -0.515810277 0 kegg kegg NA NA no up up no no no Focal adhesion Prevotella 0 -0.459481269 0 acetate-producing kegg Genus NA 0.287 no up up no no no Focal adhesion Primary bile acid biosynthesis 0 0.494071146 0 kegg kegg NA NA no up up no no no Focal adhesion Propanoate metabolism 0 0.498023715 0 kegg kegg NA NA no up up no no no Focal adhesion Proteasome -0.516521739 0.613636364 0 kegg kegg NA NA no up up no no no Focal adhesion Protein export -0.436521739 0.551383399 0 kegg kegg NA NA no up up no no no Focal adhesion Purine metabolism 0 0 -0.527155727 kegg kegg NA NA no up up no no no Focal adhesion Pyrimidine metabolism 0 0.467391304 0 kegg kegg NA NA no up up no no no Focal adhesion Pyruvate metabolism 0 0.495059289 0 kegg kegg NA NA no up up no no no Focal adhesion Rap1 signaling pathway 0.824347826 0.804347826 0.71969112 kegg kegg NA NA no up up no no no Focal adhesion Ras signaling pathway 0 0.584980237 0 yes kegg kegg NA NA no up up no up up Focal adhesion Ribosome 0 0.477272727 0 kegg kegg NA NA no up up no no no Focal adhesion Ribosome biogenesis in eukaryotes -0.428695652 0 0 kegg kegg NA NA no up up no no no Focal adhesion RNA polymerase -0.583478261 0 0 kegg kegg NA NA no up up no no no Focal adhesion Selenocompound metabolism -0.663478261 -0.415019763 0 kegg kegg NA NA no up up no no no Focal adhesion SNARE interactions in vesicular transport 0 -0.681818182 0 kegg kegg NA NA no up up no no no Focal adhesion Sphingolipid signaling pathway 0 0 0.431660232 kegg kegg NA NA no up up no no no Focal adhesion Spliceosome -0.606956522 -0.613636364 0 kegg kegg NA NA no up up no no no Focal adhesion Starch and sucrose metabolism 0 -0.476284585 0 kegg kegg NA NA no up up no no no Focal adhesion Steroid hormone biosynthesis 0 0.473320158 0 kegg kegg NA NA no up up no no no Focal adhesion Taurine and hypotaurine metabolism -0.444347826 -0.736166008 0 kegg kegg NA NA no up up no no no Focal adhesion TGF-beta signaling pathway 0 0.584980237 0 kegg kegg NA NA no up up no no no Focal adhesion Thiamine metabolism 0 0 -0.482110682 kegg kegg NA NA no up up no no no Focal adhesion Tryptophan metabolism 0 0.583003953 0 kegg kegg NA NA no up up no up no Focal adhesion Tyrosine metabolism 0 0.583992095 0 kegg kegg NA NA no up up no no no Focal adhesion "Valine, leucine and isoleucine degradation" 0 0.475296443 0 kegg kegg NA NA no up up no no no Focal adhesion Vascular smooth muscle contraction 0 0.595849802 0 kegg kegg NA NA no up up no no no Focal adhesion Viral protein interaction with cytokine and cytokine receptor 0 0 0.438352638 kegg kegg NA NA no up up no no no Focal adhesion Wnt signaling pathway 0 0.42687747 0 kegg kegg NA NA no up up no no no Folate biosynthesis "Alanine, aspartate and glutamate metabolism" 0 -0.7243083 0 kegg kegg NA NA no no no no no no Folate biosynthesis alpha-Linolenic acid metabolism 0 -0.608695652 0 kegg kegg NA NA no no no no no no Folate biosynthesis Arginine and proline metabolism 0 -0.592885375 0 kegg kegg NA NA no no no no up no Folate biosynthesis Arginine biosynthesis 0 -0.765810277 0 kegg kegg NA NA no no no no no no Folate biosynthesis Ascorbate and aldarate metabolism 0 0.519762846 0 kegg kegg NA NA no no no no no no Folate biosynthesis Butanoate metabolism 0 0.453557312 0 kegg kegg NA NA no no no no no no Folate biosynthesis Citrate cycle (TCA cycle) 0 0.450592885 0 kegg kegg NA NA no no no no no no Folate biosynthesis Cysteine and methionine metabolism 0.456521739 0 0 kegg kegg NA NA no no no no no no Folate biosynthesis Ether lipid metabolism 0 0.555335968 0 kegg kegg NA NA no no no no no no Folate biosynthesis Fatty acid biosynthesis 0 -0.677865613 0 kegg kegg NA NA no no no no no no Folate biosynthesis Fatty acid degradation 0 -0.513833992 0 kegg kegg NA NA no no no no no no Folate biosynthesis Glycerolipid metabolism 0 0 0.419047619 kegg kegg NA NA no no no no no up Folate biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.657114625 0.426512227 kegg kegg NA NA no no no no no no Folate biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate 0 0.714426877 0.564221364 kegg kegg NA NA no no no no no no Folate biosynthesis Glyoxylate and dicarboxylate metabolism 0 -0.745059289 0 kegg kegg NA NA no no no no no no Folate biosynthesis Inositol phosphate metabolism 0.406086957 0 0 kegg kegg NA NA no no no no no no Folate biosynthesis Mannose type O-glycan biosynthesis 0 0.575098814 0 kegg kegg NA NA no no no no no no Folate biosynthesis N-Glycan biosynthesis 0 0.766798419 0 kegg kegg NA NA no no no no no no Folate biosynthesis Nicotinate and nicotinamide metabolism 0 -0.693675889 0 kegg kegg NA NA no no no no no no Folate biosynthesis One carbon pool by folate 0 0.447628458 0 kegg kegg NA NA no no no no no no Folate biosynthesis Other types of O-glycan biosynthesis 0.44173913 0 0 kegg kegg NA NA no no no no no no Folate biosynthesis Oxidative phosphorylation 0 0.445652174 0 kegg kegg NA NA no no no no no no Folate biosynthesis Pantothenate and CoA biosynthesis 0 -0.663043478 0 kegg kegg NA NA no no no no no dn Folate biosynthesis Pentose and glucuronate interconversions 0.473913043 0.630434783 0 kegg kegg NA NA no no no no no no Folate biosynthesis Pentose phosphate pathway 0 -0.500988142 0 kegg kegg NA NA no no no no no no Folate biosynthesis Phenylalanine metabolism 0 0.427865613 0 kegg kegg NA NA no no no no no no Folate biosynthesis Pyrimidine metabolism 0 0.427865613 0 kegg kegg NA NA no no no no no no Folate biosynthesis Pyruvate metabolism 0.424347826 0 0 kegg kegg NA NA no no no no no no Folate biosynthesis Starch and sucrose metabolism 0 -0.578063241 0 kegg kegg NA NA no no no no no no Folate biosynthesis Steroid hormone biosynthesis 0 0 0.624710425 kegg kegg NA NA no no no no no no Folate biosynthesis Synthesis and degradation of ketone bodies 0.46173913 0 0 kegg kegg NA NA no no no no no no Folate biosynthesis Thiamine metabolism 0.582608696 0 0 kegg kegg NA NA no no no no no no Folate biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis 0.493913043 0 0 kegg kegg NA NA no no no no no no Folate biosynthesis "Valine, leucine and isoleucine degradation" 0 0.423913043 0 kegg kegg NA NA no no no no no no Folate biosynthesis Various types of N-glycan biosynthesis 0 0.744071146 0 kegg kegg NA NA no no no no no no FoxO signaling pathway ABC transporters 0 0.744071146 0 kegg kegg NA NA no no no no up up FoxO signaling pathway "Alanine, aspartate and glutamate metabolism" 0.493913043 0.645256917 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Alistipes -0.558083924 0 0 kegg Genus NA 0.0114 no no no no up no FoxO signaling pathway alpha-Linolenic acid metabolism 0 0.68972332 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Aminoacyl-tRNA biosynthesis 0 0 0.4002574 kegg kegg NA NA no no no no no no FoxO signaling pathway Arachidonic acid metabolism -0.465217391 0 -0.428056628 kegg kegg NA NA no no no no no no FoxO signaling pathway Arginine and proline metabolism 0 0.494071146 0 kegg kegg NA NA no no no no up no FoxO signaling pathway Arginine biosynthesis 0.46173913 0.567193676 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Basal transcription factors 0 0 0.504504505 kegg kegg NA NA no no no no no no FoxO signaling pathway Base excision repair 0 0 0.49034749 kegg kegg NA NA no no no no no no FoxO signaling pathway Bifidobacterium 0 -0.422487675 0 acetate-producing kegg Genus NA 0.105 no no no no dn no FoxO signaling pathway Biosynthesis of cofactors -0.475652174 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Calcium signaling pathway 0 -0.514822134 0 kegg kegg NA NA no no no no up up FoxO signaling pathway cGMP-PKG signaling pathway 0.586086957 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Chemokine signaling pathway 0 0 -0.406949807 kegg kegg NA NA no no no no no no FoxO signaling pathway Citrate cycle (TCA cycle) 0 -0.442687747 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Clostridium 0 -0.486989016 0 kegg Genus NA 0.925 no no no no no no FoxO signaling pathway Cysteine and methionine metabolism 0 0 0.428314028 kegg kegg NA NA no no no no no no FoxO signaling pathway Cytokine-cytokine receptor interaction 0.477391304 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Drug metabolism - cytochrome P450 0 -0.538537549 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Drug metabolism - other enzymes 0 -0.716403162 0 kegg kegg NA NA no no no no no no FoxO signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.536561265 0 kegg kegg NA NA no no no no no no FoxO signaling pathway ErbB signaling pathway 0 0.657114625 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Fanconi anemia pathway 0 0 0.565508366 kegg kegg NA NA no no no no no no FoxO signaling pathway Fatty acid biosynthesis 0.584347826 0.691699605 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Fatty acid degradation 0.48173913 0.716403162 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Fatty acid metabolism 0 0.62944664 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Fructose and mannose metabolism 0 0.505928854 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Galactose metabolism 0 0.719367589 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Glutathione metabolism -0.586956522 -0.60770751 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Glycerolipid metabolism 0 0.825098814 0 kegg kegg NA NA no no no no no up FoxO signaling pathway Glycerophospholipid metabolism 0 0.650197628 0 kegg kegg NA NA no no no no no up FoxO signaling pathway "Glycine, serine and threonine metabolism" -0.579130435 0 0 kegg kegg NA NA no no no no up no FoxO signaling pathway Glycolysis / Gluconeogenesis 0 -0.614624506 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.747035573 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Glycosphingolipid biosynthesis - ganglio series -0.446956522 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.443478261 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.537549407 0 kegg kegg NA NA no no no no no no FoxO signaling pathway HIF-1 signaling pathway 0 -0.615612648 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Homologous recombination 0.496521739 0.482213439 0.628828829 kegg kegg NA NA no no no no no no FoxO signaling pathway Inositol phosphate metabolism 0.411304348 0.770750988 0.500643501 kegg kegg NA NA no no no no no no FoxO signaling pathway Lachnospira 0 -0.490239699 0 butyrate-producing kegg Genus NA 0.279 no no no no no no FoxO signaling pathway MAPK signaling pathway 0.696521739 0.710474308 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.550395257 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Mucin type O-glycan biosynthesis 0 0.491106719 0.507335907 kegg kegg NA NA no no no no no no FoxO signaling pathway N-Glycan biosynthesis 0 0 0.491634492 kegg kegg NA NA no no no no no no FoxO signaling pathway NF-kappa B signaling pathway 0.520869565 0.668972332 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Nicotinate and nicotinamide metabolism 0.51826087 0.604743083 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Nitrogen metabolism 0 0.454545455 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Nucleotide excision repair 0 0 0.511196911 kegg kegg NA NA no no no no no no FoxO signaling pathway Oscillospira 0 0.533596838 0 LPS-producing kegg Genus NA 0.62 no no no no no no FoxO signaling pathway Other glycan degradation 0 0.54743083 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Other types of O-glycan biosynthesis 0 0 0.459202059 kegg kegg NA NA no no no no no no FoxO signaling pathway Oxidative phosphorylation 0 -0.765810277 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Pantothenate and CoA biosynthesis 0.69826087 0.608695652 0 kegg kegg NA NA no no no no no dn FoxO signaling pathway Pentose and glucuronate interconversions 0 -0.455533597 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Platinum drug resistance 0.643478261 0.714426877 0.797425997 kegg kegg NA NA no no no no no no FoxO signaling pathway Porphyrin and chlorophyll metabolism -0.50173913 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Prevotella 0 0.456424852 0 acetate-producing kegg Genus NA 0.287 no no no no no no FoxO signaling pathway Proteasome 0 -0.626482213 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Protein export 0 -0.722332016 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Pyruvate metabolism 0 -0.475296443 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Rap1 signaling pathway 0 -0.617588933 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Ras signaling pathway 0 -0.457509881 0 yes kegg kegg NA NA no no no no up up FoxO signaling pathway Retinol metabolism 0 0 0.415186615 kegg kegg NA NA no no no no no no FoxO signaling pathway Ribosome 0 -0.735177866 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Ribosome biogenesis in eukaryotes 0 0 0.431660232 kegg kegg NA NA no no no no no no FoxO signaling pathway RNA degradation 0 -0.445652174 0 kegg kegg NA NA no no no no no no FoxO signaling pathway RNA transport 0 -0.500988142 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Ruminococcus 0 -0.573553022 0 kegg Genus NA 0.0679 no no no no no dn FoxO signaling pathway Ruminococcus -0.47826087 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no FoxO signaling pathway Selenocompound metabolism 0 0.507905138 0.557014157 kegg kegg NA NA no no no no no no FoxO signaling pathway Spliceosome 0.410434783 0.558300395 0.464350064 kegg kegg NA NA no no no no no no FoxO signaling pathway Starch and sucrose metabolism 0 0.653162055 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Steroid biosynthesis 0 0 0.412355212 kegg kegg NA NA no no no no no no FoxO signaling pathway Sulfur metabolism -0.450434783 0 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Synthesis and degradation of ketone bodies 0 0 0.403861004 kegg kegg NA NA no no no no no no FoxO signaling pathway Taurine and hypotaurine metabolism 0.416521739 0.690711462 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Thiamine metabolism 0 -0.421936759 0 kegg kegg NA NA no no no no no no FoxO signaling pathway Various types of N-glycan biosynthesis 0 0 0.504761905 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Citrate cycle (TCA cycle) 0.431304348 0 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Glycolysis / Gluconeogenesis 0.769565217 -0.524703557 0 kegg kegg NA NA no no no no no no Fructose and mannose metabolism Pentose phosphate pathway 0.556521739 0 0.55032175 kegg kegg NA NA no no no no no no Fusobacterium Holdemania 0.494150797 0 0 Genus Genus 0.628 0.289 no no no no no no GABAergic synapse 2-Oxocarboxylic acid metabolism 0 -0.726284585 -0.600772201 kegg kegg NA NA no up up no no no GABAergic synapse Adherens junction -0.423478261 -0.537549407 0 kegg kegg NA NA no up up no no no GABAergic synapse Adrenergic signaling in cardiomyocytes 0 -0.46541502 0 kegg kegg NA NA no up up no no up GABAergic synapse "Alanine, aspartate and glutamate metabolism" 0.767826087 0.789525692 0.791248391 kegg kegg NA NA no up up no no no GABAergic synapse Alistipes -0.59913235 0 0 kegg Genus NA 0.0114 no up up no up no GABAergic synapse alpha-Linolenic acid metabolism 0 0.531620553 0 kegg kegg NA NA no up up no no no GABAergic synapse Aminoacyl-tRNA biosynthesis 0 -0.543478261 -0.447361647 kegg kegg NA NA no up up no no no GABAergic synapse Antifolate resistance -0.44 0 0 kegg kegg NA NA no up up no no no GABAergic synapse Apelin signaling pathway 0 -0.466403162 -0.436550837 kegg kegg NA NA no up up no no no GABAergic synapse Arginine and proline metabolism 0.615652174 0.821146245 0.63989704 kegg kegg NA NA no up up no up no GABAergic synapse Arginine biosynthesis 0.757391304 0.831027668 0.845559846 kegg kegg NA NA no up up no no no GABAergic synapse Ascorbate and aldarate metabolism 0 -0.604743083 0 kegg kegg NA NA no up up no no no GABAergic synapse Autophagy - animal 0.509565217 0.613636364 0 kegg kegg NA NA no up up no no no GABAergic synapse B cell receptor signaling pathway 0 0.46541502 0 kegg kegg NA NA no up up no no no GABAergic synapse Bifidobacterium 0 -0.419515898 0 acetate-producing kegg Genus NA 0.105 no up up no dn no GABAergic synapse Biosynthesis of amino acids 0 0.613636364 0.517631918 kegg kegg NA NA no up up no no no GABAergic synapse Biosynthesis of cofactors -0.425217391 0 0 kegg kegg NA NA no up up no no no GABAergic synapse Butanoate metabolism 0 -0.537549407 0 kegg kegg NA NA no up up no no no GABAergic synapse C-type lectin receptor signaling pathway 0 0.471343874 0 kegg kegg NA NA no up up no no no GABAergic synapse Cardiac muscle contraction 0 -0.686758893 -0.400514801 kegg kegg NA NA no up up no no up GABAergic synapse Cell cycle 0 -0.456521739 -0.494723295 kegg kegg NA NA no up up no no no GABAergic synapse cGMP-PKG signaling pathway 0.576521739 0.630434783 0 kegg kegg NA NA no up up no no no GABAergic synapse Chemokine signaling pathway 0 0.709486166 0 kegg kegg NA NA no up up no no no GABAergic synapse Cholinergic synapse 0.551304348 0.64229249 0 kegg kegg NA NA no up up no no no GABAergic synapse Circadian rhythm 0 0 -0.403088803 kegg kegg NA NA no up up no no no GABAergic synapse Citrate cycle (TCA cycle) 0 -0.586956522 0 kegg kegg NA NA no up up no no no GABAergic synapse Complement and coagulation cascades 0.425217391 0.741106719 0.457142857 kegg kegg NA NA no up up no no no GABAergic synapse Cysteine and methionine metabolism 0 -0.477272727 -0.405405405 kegg kegg NA NA no up up no no no GABAergic synapse Cytokine-cytokine receptor interaction 0 0.548418972 0 kegg kegg NA NA no up up no no no GABAergic synapse DNA replication 0 -0.583992095 -0.451480051 kegg kegg NA NA no up up no no no GABAergic synapse Drug metabolism - cytochrome P450 0 -0.600790514 0 kegg kegg NA NA no up up no no no GABAergic synapse Drug metabolism - other enzymes 0 -0.633399209 0 kegg kegg NA NA no up up no no no GABAergic synapse EGFR tyrosine kinase inhibitor resistance 0 -0.460474308 0 kegg kegg NA NA no up up no no no GABAergic synapse Ether lipid metabolism -0.534782609 -0.501976285 -0.469498069 kegg kegg NA NA no up up no no no GABAergic synapse Fanconi anemia pathway 0 0 -0.415958816 kegg kegg NA NA no up up no no no GABAergic synapse Fatty acid biosynthesis 0.831304348 0.764822134 0.605405405 kegg kegg NA NA no up up no no no GABAergic synapse Fatty acid degradation 0.567826087 0.577075099 0 kegg kegg NA NA no up up no no no GABAergic synapse Fatty acid metabolism 0.548695652 0.646245059 0 kegg kegg NA NA no up up no no no GABAergic synapse Fc epsilon RI signaling pathway 0 0.568181818 0 kegg kegg NA NA no up up no no no GABAergic synapse Fc gamma R-mediated phagocytosis 0.499130435 0.574110672 0.64015444 kegg kegg NA NA no up up no no no GABAergic synapse Focal adhesion 0 -0.463438735 0 kegg kegg NA NA no up up no up up GABAergic synapse Folate biosynthesis 0 -0.736166008 0 kegg kegg NA NA no up up no no no GABAergic synapse FoxO signaling pathway 0.525217391 0.507905138 0 kegg kegg NA NA no up up no no no GABAergic synapse Glutamatergic synapse 0 0.650197628 0.621364221 kegg kegg NA NA no up up no up up GABAergic synapse Glycerolipid metabolism 0 0 -0.532046332 kegg kegg NA NA no up up no no up GABAergic synapse Glycerophospholipid metabolism 0 0 -0.449420849 kegg kegg NA NA no up up no no up GABAergic synapse Glycolysis / Gluconeogenesis 0 -0.46541502 0 kegg kegg NA NA no up up no no no GABAergic synapse Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.500869565 0.56027668 0 kegg kegg NA NA no up up no no no GABAergic synapse Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.491106719 -0.55958816 kegg kegg NA NA no up up no no no GABAergic synapse Glycosaminoglycan biosynthesis - keratan sulfate 0 -0.505928854 0 kegg kegg NA NA no up up no no no GABAergic synapse Glycosphingolipid biosynthesis - ganglio series 0 -0.473320158 -0.441956242 kegg kegg NA NA no up up no no no GABAergic synapse Glyoxylate and dicarboxylate metabolism 0.663478261 0.81916996 0.794079794 kegg kegg NA NA no up up no no no GABAergic synapse Hedgehog signaling pathway 0 0 -0.507078507 kegg kegg NA NA no up up no no no GABAergic synapse HIF-1 signaling pathway 0 -0.463438735 0 kegg kegg NA NA no up up no no no GABAergic synapse Hippo signaling pathway -0.51826087 -0.672924901 0 kegg kegg NA NA no up up no no no GABAergic synapse Hippo signaling pathway - multiple species 0 0.517786561 0 kegg kegg NA NA no up up no no no GABAergic synapse IL-17 signaling pathway 0.528695652 0.549407115 0.619305019 kegg kegg NA NA no up up no no no GABAergic synapse Inositol phosphate metabolism 0 0 -0.415701416 kegg kegg NA NA no up up no no no GABAergic synapse JAK-STAT signaling pathway 0 0.470355731 0 kegg kegg NA NA no up up no no no GABAergic synapse Lysine degradation 0 0 -0.599485199 kegg kegg NA NA no up up no no no GABAergic synapse Lysosome 0.436521739 0 0.40978121 kegg kegg NA NA no up up no no no GABAergic synapse Mannose type O-glycan biosynthesis 0 -0.444664032 -0.561904762 kegg kegg NA NA no up up no no no GABAergic synapse Metabolism of xenobiotics by cytochrome P450 0 -0.609683794 0 kegg kegg NA NA no up up no no no GABAergic synapse Mitophagy - animal -0.419130435 0 0 kegg kegg NA NA no up up no no no GABAergic synapse mRNA surveillance pathway 0 -0.654150198 -0.553153153 kegg kegg NA NA no up up no no no GABAergic synapse mTOR signaling pathway 0 -0.450592885 0 kegg kegg NA NA no up up no no no GABAergic synapse N-Glycan biosynthesis 0 -0.716403162 -0.533590734 kegg kegg NA NA no up up no no no GABAergic synapse Neuroactive ligand-receptor interaction 0 0.441699605 0.522522523 kegg kegg NA NA no up up up up up GABAergic synapse Neutrophil extracellular trap formation 0.420869565 0.567193676 0.468468468 kegg kegg NA NA no up up no no no GABAergic synapse NF-kappa B signaling pathway 0 0.567193676 0 kegg kegg NA NA no up up no no no GABAergic synapse Nicotinate and nicotinamide metabolism 0.746086957 0.745059289 0.657657658 kegg kegg NA NA no up up no no no GABAergic synapse Nitrogen metabolism 0.700869565 0.897233202 0.885714286 kegg kegg NA NA no up up no no no GABAergic synapse NOD-like receptor signaling pathway 0.691304348 0.508893281 0 kegg kegg NA NA no up up no no no GABAergic synapse One carbon pool by folate 0 -0.473320158 -0.663320463 kegg kegg NA NA no up up no no no GABAergic synapse Osteoclast differentiation 0.405217391 0.546442688 0.561132561 kegg kegg NA NA no up up no no no GABAergic synapse Other glycan degradation 0 0 -0.466924067 kegg kegg NA NA no up up no no no GABAergic synapse Other types of O-glycan biosynthesis 0 0 -0.419047619 kegg kegg NA NA no up up no no no GABAergic synapse Oxidative phosphorylation 0 -0.643280632 0 kegg kegg NA NA no up up no no no GABAergic synapse Pantothenate and CoA biosynthesis 0.593043478 0.650197628 0.46975547 kegg kegg NA NA no up up no no dn GABAergic synapse Paraprevotella 0 -0.485193251 0 kegg Genus NA 0.118 no up up no no no GABAergic synapse Pentose and glucuronate interconversions 0 -0.738142292 -0.644015444 kegg kegg NA NA no up up no no no GABAergic synapse Pentose phosphate pathway 0 0.520750988 0.547232947 kegg kegg NA NA no up up no no no GABAergic synapse Peroxisome 0.673913043 0.647233202 0.514543115 kegg kegg NA NA no up up no no no GABAergic synapse Phenylalanine metabolism -0.446086957 -0.54743083 0 kegg kegg NA NA no up up no no no GABAergic synapse Phosphatidylinositol signaling system 0 0 -0.449420849 kegg kegg NA NA no up up no no no GABAergic synapse Phospholipase D signaling pathway 0 0.556324111 0 kegg kegg NA NA no up up no up up GABAergic synapse PPAR signaling pathway 0.468695652 0.513833992 0.476190476 kegg kegg NA NA no up up no no no GABAergic synapse Propanoate metabolism 0 -0.416007905 0 kegg kegg NA NA no up up no no no GABAergic synapse Proteasome 0 -0.650197628 0 kegg kegg NA NA no up up no no no GABAergic synapse Protein export 0 -0.713438735 -0.552638353 kegg kegg NA NA no up up no no no GABAergic synapse Protein processing in endoplasmic reticulum 0 -0.657114625 0 kegg kegg NA NA no up up no no no GABAergic synapse Pyruvate metabolism 0 -0.529644269 0 kegg kegg NA NA no up up no no no GABAergic synapse Ras signaling pathway 0 -0.423913043 0 yes kegg kegg NA NA no up up no up up GABAergic synapse Renin-angiotensin system 0.513043478 0.479249012 0.571428571 kegg kegg NA NA no up up no no no GABAergic synapse Retrograde endocannabinoid signaling 0 -0.471343874 0 kegg kegg NA NA no up up no no up GABAergic synapse Ribosome -0.472173913 -0.514822134 -0.408494208 kegg kegg NA NA no up up no no no GABAergic synapse Ribosome biogenesis in eukaryotes 0 -0.548418972 -0.541055341 kegg kegg NA NA no up up no no no GABAergic synapse RIG-I-like receptor signaling pathway 0.431304348 0.583003953 0 kegg kegg NA NA no up up no no no GABAergic synapse RNA degradation 0 -0.7756917 -0.592535393 kegg kegg NA NA no up up no no no GABAergic synapse RNA polymerase 0 -0.666996047 -0.518918919 kegg kegg NA NA no up up no no no GABAergic synapse RNA transport 0 -0.463438735 0 kegg kegg NA NA no up up no no no GABAergic synapse Ruminococcus -0.433043478 0 0 acetate-producing kegg Genus NA 0.335 no up up no no no GABAergic synapse Serotonergic synapse 0 0.47826087 0 kegg kegg NA NA no up up no no no GABAergic synapse Spliceosome 0 0 -0.401544402 kegg kegg NA NA no up up no no no GABAergic synapse Starch and sucrose metabolism 0 0.592885375 0 kegg kegg NA NA no up up no no no GABAergic synapse Synaptic vesicle cycle 0 0.555335968 0 kegg kegg NA NA no up up no up up GABAergic synapse TGF-beta signaling pathway 0 -0.526679842 0 kegg kegg NA NA no up up no no no GABAergic synapse Th1 and Th2 cell differentiation 0 0 -0.412355212 kegg kegg NA NA no up up no no no GABAergic synapse Th17 cell differentiation 0 0 -0.401801802 kegg kegg NA NA no up up no no no GABAergic synapse Thermogenesis -0.485217391 -0.650197628 -0.441956242 kegg kegg NA NA no up up no no no GABAergic synapse Toll-like receptor signaling pathway 0 0.563241107 0 yes kegg kegg NA NA no up up no no no GABAergic synapse Ubiquinone and other terpenoid-quinone biosynthesis 0 0 -0.412355212 kegg kegg NA NA no up up no no no GABAergic synapse Ubiquitin mediated proteolysis -0.556521739 -0.467391304 0 kegg kegg NA NA no up up no no no GABAergic synapse "Valine, leucine and isoleucine degradation" 0 -0.545454545 0 kegg kegg NA NA no up up no no no GABAergic synapse Various types of N-glycan biosynthesis 0 -0.599802372 -0.44041184 kegg kegg NA NA no up up no no no GABAergic synapse Vascular smooth muscle contraction 0 -0.462450593 0 kegg kegg NA NA no up up no no no GABAergic synapse VEGF signaling pathway 0 0.503952569 0 kegg kegg NA NA no up up no no no GABAergic synapse Viral protein interaction with cytokine and cytokine receptor 0 0.586956522 0 kegg kegg NA NA no up up no no no GABAergic synapse Wnt signaling pathway -0.455652174 -0.720355731 -0.516087516 kegg kegg NA NA no up up no no no Galactose metabolism Citrate cycle (TCA cycle) 0.460869565 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Fructose and mannose metabolism 0.886956522 0.583992095 0.798970399 kegg kegg NA NA no no no no no no Galactose metabolism Glycolysis / Gluconeogenesis 0.648695652 0 0 kegg kegg NA NA no no no no no no Galactose metabolism Pentose phosphate pathway 0.582608696 0.46541502 0 kegg kegg NA NA no no no no no no Gap junction 2-Oxocarboxylic acid metabolism 0 0 -0.498841699 kegg kegg NA NA no no no no no no Gap junction ABC transporters -0.499130435 0 -0.44967825 kegg kegg NA NA no no no no up up Gap junction Adrenergic signaling in cardiomyocytes 0.457391304 0 0 kegg kegg NA NA no no no no no up Gap junction alpha-Linolenic acid metabolism 0 0 -0.432947233 kegg kegg NA NA no no no no no no Gap junction AMPK signaling pathway 0.419130435 0 0.558558559 kegg kegg NA NA no no no no no no Gap junction Arachidonic acid metabolism 0 0.499011858 0.423166023 kegg kegg NA NA no no no no no no Gap junction Arginine and proline metabolism -0.513043478 0 0 kegg kegg NA NA no no no no up no Gap junction Ascorbate and aldarate metabolism 0 0 -0.689317889 kegg kegg NA NA no no no no no no Gap junction Autophagy - animal -0.446956522 0 0 kegg kegg NA NA no no no no no no Gap junction Autophagy - other 0 0 -0.427799228 kegg kegg NA NA no no no no no no Gap junction Basal transcription factors 0 0 -0.502960103 kegg kegg NA NA no no no no no no Gap junction beta-Alanine metabolism 0 -0.502964427 0 kegg kegg NA NA no no no no no no Gap junction Biosynthesis of cofactors 0 0 0.532561133 kegg kegg NA NA no no no no no no Gap junction Butanoate metabolism 0 -0.45256917 0 kegg kegg NA NA no no no no no no Gap junction Calcium signaling pathway 0 0.485177866 0 kegg kegg NA NA no no no no up up Gap junction cAMP signaling pathway 0 0.503952569 0 yes kegg kegg NA NA no no no no up up Gap junction Carbon metabolism 0 -0.62055336 0 kegg kegg NA NA no no no no no no Gap junction Citrate cycle (TCA cycle) 0 -0.540513834 -0.60952381 kegg kegg NA NA no no no no no no Gap junction Clostridium 0 -0.562380621 0 kegg Genus NA 0.925 no no no no no no Gap junction Cysteine and methionine metabolism 0 -0.472332016 0 kegg kegg NA NA no no no no no no Gap junction DNA replication 0 0 -0.461776062 kegg kegg NA NA no no no no no no Gap junction Drug metabolism - other enzymes 0 0 -0.625225225 kegg kegg NA NA no no no no no no Gap junction Endocrine resistance 0.65826087 0.666007905 0.661518662 kegg kegg NA NA no no no no no no Gap junction Ether lipid metabolism 0 0 -0.457915058 kegg kegg NA NA no no no no no no Gap junction Fanconi anemia pathway 0 0 -0.457142857 kegg kegg NA NA no no no no no no Gap junction Fatty acid degradation -0.415652174 0 -0.484427284 kegg kegg NA NA no no no no no no Gap junction Fatty acid elongation 0 -0.545454545 0 kegg kegg NA NA no no no no no no Gap junction Ferroptosis 0.463478261 0.60770751 0 kegg kegg NA NA no no no no no no Gap junction Focal adhesion 0.41826087 0 0 kegg kegg NA NA no no no no up up Gap junction Folate biosynthesis -0.546086957 0 0 kegg kegg NA NA no no no no no no Gap junction Fructose and mannose metabolism 0 0 -0.424453024 kegg kegg NA NA no no no no no no Gap junction Galactose metabolism 0 0 -0.578378378 kegg kegg NA NA no no no no no no Gap junction Glutathione metabolism 0 0 0.552638353 kegg kegg NA NA no no no no no no Gap junction Glycerolipid metabolism -0.457391304 0 -0.644272844 kegg kegg NA NA no no no no no up Gap junction Glycerophospholipid metabolism 0 0 -0.677477477 kegg kegg NA NA no no no no no up Gap junction "Glycine, serine and threonine metabolism" 0.509565217 0 0.558043758 kegg kegg NA NA no no no no up no Gap junction Glycolysis / Gluconeogenesis 0 -0.54743083 0 kegg kegg NA NA no no no no no no Gap junction Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.587644788 kegg kegg NA NA no no no no no no Gap junction Glycosaminoglycan degradation 0 0 -0.684169884 kegg kegg NA NA no no no no no up Gap junction Glyoxylate and dicarboxylate metabolism -0.464347826 0 0 kegg kegg NA NA no no no no no no Gap junction Hedgehog signaling pathway 0 0 -0.505791506 kegg kegg NA NA no no no no no no Gap junction Hippo signaling pathway 0.413913043 0 0 kegg kegg NA NA no no no no no no Gap junction Hippo signaling pathway - multiple species -0.573913043 0 -0.544916345 kegg kegg NA NA no no no no no no Gap junction Inositol phosphate metabolism 0 0 -0.527413127 kegg kegg NA NA no no no no no no Gap junction Longevity regulating pathway 0 0.434782609 0.439124839 kegg kegg NA NA no no no no no no Gap junction Longevity regulating pathway - multiple species 0 -0.586956522 0 kegg kegg NA NA no no no no no no Gap junction Lysine degradation 0 0 -0.563191763 kegg kegg NA NA no no no no no no Gap junction Mannose type O-glycan biosynthesis 0 0 -0.529214929 kegg kegg NA NA no no no no no no Gap junction MAPK signaling pathway 0 0 -0.452509653 kegg kegg NA NA no no no no no no Gap junction Mucin type O-glycan biosynthesis 0 -0.482213439 0 kegg kegg NA NA no no no no no no Gap junction Necroptosis 0.491304348 0.533596838 0.420592021 kegg kegg NA NA no no no no no no Gap junction NF-kappa B signaling pathway -0.584347826 0 0 kegg kegg NA NA no no no no no no Gap junction Nicotinate and nicotinamide metabolism -0.487826087 0 0 kegg kegg NA NA no no no no no no Gap junction Non-homologous end-joining 0 -0.588932806 0 kegg kegg NA NA no no no no no no Gap junction Notch signaling pathway 0 0 -0.676962677 kegg kegg NA NA no no no no no no Gap junction Odoribacter -0.422570892 -0.608719053 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Gap junction One carbon pool by folate 0 0 -0.463577864 kegg kegg NA NA no no no no no no Gap junction Oocyte meiosis 0 -0.54743083 0 kegg kegg NA NA no no no no no no Gap junction Osteoclast differentiation -0.547826087 0 0 kegg kegg NA NA no no no no no no Gap junction Other glycan degradation -0.523478261 0 -0.615958816 kegg kegg NA NA no no no no no no Gap junction Other types of O-glycan biosynthesis 0 0 -0.528700129 kegg kegg NA NA no no no no no no Gap junction Pentose and glucuronate interconversions 0 0 -0.426254826 kegg kegg NA NA no no no no no no Gap junction Peroxisome -0.54 0 0 kegg kegg NA NA no no no no no no Gap junction Phosphatidylinositol signaling system 0 0 -0.489060489 kegg kegg NA NA no no no no no no Gap junction Phospholipase D signaling pathway 0 0.552371542 0.425225225 kegg kegg NA NA no no no no up up Gap junction Porphyrin and chlorophyll metabolism 0.493043478 0 0.532046332 kegg kegg NA NA no no no no no no Gap junction PPAR signaling pathway -0.429565217 0 0 kegg kegg NA NA no no no no no no Gap junction Prevotella -0.411589322 0 0 kegg Genus NA 0.367 no no no no no no Gap junction Primary bile acid biosynthesis 0 -0.630434783 0 kegg kegg NA NA no no no no no no Gap junction Propanoate metabolism 0 -0.502964427 0 kegg kegg NA NA no no no no no no Gap junction Proteasome 0 -0.633399209 -0.624710425 kegg kegg NA NA no no no no no no Gap junction Pyrimidine metabolism 0 0 -0.531016731 kegg kegg NA NA no no no no no no Gap junction Rap1 signaling pathway 0.426956522 0 0.506563707 kegg kegg NA NA no no no no no no Gap junction Retinol metabolism 0 0 -0.496782497 kegg kegg NA NA no no no no no no Gap junction Ribosome biogenesis in eukaryotes 0 0 -0.502702703 kegg kegg NA NA no no no no no no Gap junction RNA degradation 0 0 -0.560617761 kegg kegg NA NA no no no no no no Gap junction RNA polymerase 0 0 -0.457657658 kegg kegg NA NA no no no no no no Gap junction Selenocompound metabolism 0 0 -0.589189189 kegg kegg NA NA no no no no no no Gap junction SNARE interactions in vesicular transport -0.716521739 0 -0.461003861 kegg kegg NA NA no no no no no no Gap junction Sphingolipid metabolism 0 0 -0.455855856 kegg kegg NA NA no no no no no no Gap junction Starch and sucrose metabolism 0 0 -0.459459459 kegg kegg NA NA no no no no no no Gap junction Steroid hormone biosynthesis 0 0 -0.534362934 kegg kegg NA NA no no no no no no Gap junction Taurine and hypotaurine metabolism 0 0 -0.446074646 kegg kegg NA NA no no no no no no Gap junction Terpenoid backbone biosynthesis 0 -0.450592885 -0.545431145 kegg kegg NA NA no no no no no no Gap junction Tryptophan metabolism 0 -0.618577075 -0.506306306 kegg kegg NA NA no no no no up no Gap junction "Valine, leucine and isoleucine degradation" 0 -0.416996047 0 kegg kegg NA NA no no no no no no Gap junction Vascular smooth muscle contraction 0.423478261 0 0.541827542 kegg kegg NA NA no no no no no no Gap junction VEGF signaling pathway 0 0 -0.403603604 kegg kegg NA NA no no no no no no Gap junction Viral protein interaction with cytokine and cytokine receptor 0 0 0.526126126 kegg kegg NA NA no no no no no no Gap junction Wnt signaling pathway 0 0 -0.484169884 kegg kegg NA NA no no no no no no Gastric acid secretion 2-Oxocarboxylic acid metabolism 0 0.425889328 0 kegg kegg NA NA no no no no no no Gastric acid secretion ABC transporters 0 -0.54743083 0 kegg kegg NA NA no no no no up up Gastric acid secretion Adherens junction 0.916521739 0.944664032 0.903217503 kegg kegg NA NA no no no no no no Gastric acid secretion Adipocytokine signaling pathway 0 -0.543478261 0 kegg kegg NA NA no no no no no no Gastric acid secretion Adrenergic signaling in cardiomyocytes 0 0.578063241 0 kegg kegg NA NA no no no no no up Gastric acid secretion AGE-RAGE signaling pathway in diabetic complications -0.414782609 -0.677865613 0 kegg kegg NA NA no no no no no no Gastric acid secretion "Alanine, aspartate and glutamate metabolism" -0.469565217 -0.741106719 0 kegg kegg NA NA no no no no no no Gastric acid secretion Aldosterone synthesis and secretion 0 0.510869565 0 kegg kegg NA NA no no no no up up Gastric acid secretion alpha-Linolenic acid metabolism 0 -0.499011858 0 kegg kegg NA NA no no no no no no Gastric acid secretion Apelin signaling pathway 0 0.5256917 0 kegg kegg NA NA no no no no no no Gastric acid secretion Apoptosis 0 -0.415019763 0 kegg kegg NA NA no no no no no no Gastric acid secretion Apoptosis - multiple species -0.650434783 -0.575098814 0 kegg kegg NA NA no no no no no no Gastric acid secretion Arginine and proline metabolism 0 -0.652173913 0 kegg kegg NA NA no no no no up no Gastric acid secretion Arginine biosynthesis 0 -0.669960474 0 kegg kegg NA NA no no no no no no Gastric acid secretion Ascorbate and aldarate metabolism 0 0.471343874 0 kegg kegg NA NA no no no no no no Gastric acid secretion Autophagy - animal -0.749565217 -0.901185771 -0.593307593 kegg kegg NA NA no no no no no no Gastric acid secretion Autophagy - other -0.8 -0.766798419 -0.593822394 kegg kegg NA NA no no no no no no Gastric acid secretion B cell receptor signaling pathway 0 -0.585968379 0 kegg kegg NA NA no no no no no no Gastric acid secretion Basal transcription factors -0.573043478 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Base excision repair -0.636521739 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Bifidobacterium 0 0.419515898 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Gastric acid secretion Biosynthesis of amino acids 0 -0.419960474 0 kegg kegg NA NA no no no no no no Gastric acid secretion Butanoate metabolism 0 0.462450593 0 kegg kegg NA NA no no no no no no Gastric acid secretion C-type lectin receptor signaling pathway -0.525217391 -0.68972332 -0.462548263 kegg kegg NA NA no no no no no no Gastric acid secretion Calcium signaling pathway 0 0.574110672 0 kegg kegg NA NA no no no no up up Gastric acid secretion Cardiac muscle contraction 0 0.729249012 0.555984556 kegg kegg NA NA no no no no no up Gastric acid secretion Cholinergic synapse -0.433043478 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Circadian entrainment 0.611304348 0.790513834 0.425225225 kegg kegg NA NA no no no no up up Gastric acid secretion Circadian rhythm -0.436521739 0 -0.430888031 kegg kegg NA NA no no no no no no Gastric acid secretion Citrate cycle (TCA cycle) 0 0.462450593 0 kegg kegg NA NA no no no no no no Gastric acid secretion Cytokine-cytokine receptor interaction 0 0 0.596138996 kegg kegg NA NA no no no no no no Gastric acid secretion Dopaminergic synapse 0 0.678853755 0 kegg kegg NA NA no no no no up no Gastric acid secretion Drug metabolism - cytochrome P450 0 0.634387352 0 kegg kegg NA NA no no no no no no Gastric acid secretion Drug metabolism - other enzymes 0 0.708498024 0 kegg kegg NA NA no no no no no no Gastric acid secretion EGFR tyrosine kinase inhibitor resistance -0.406086957 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Endocrine and other factor-regulated calcium reabsorption 0.56173913 0.67687747 0.43963964 kegg kegg NA NA no no no no no no Gastric acid secretion ErbB signaling pathway -0.446956522 -0.587944664 0 kegg kegg NA NA no no no no no no Gastric acid secretion Estrogen signaling pathway 0 0.52173913 0 kegg kegg NA NA no no no no no no Gastric acid secretion Fatty acid biosynthesis -0.415652174 -0.671936759 0 kegg kegg NA NA no no no no no no Gastric acid secretion Fatty acid degradation 0 -0.662055336 0 kegg kegg NA NA no no no no no no Gastric acid secretion Fatty acid metabolism 0 -0.600790514 0 kegg kegg NA NA no no no no no no Gastric acid secretion Fc epsilon RI signaling pathway 0 -0.570158103 0 kegg kegg NA NA no no no no no no Gastric acid secretion Focal adhesion 0.846086957 0.889328063 0.773230373 kegg kegg NA NA no no no no up up Gastric acid secretion FoxO signaling pathway -0.48173913 -0.765810277 0 kegg kegg NA NA no no no no no no Gastric acid secretion Fructose and mannose metabolism 0 -0.416996047 0 kegg kegg NA NA no no no no no no Gastric acid secretion GABAergic synapse -0.440869565 -0.546442688 0 kegg kegg NA NA no no no no up up Gastric acid secretion Galactose metabolism 0 -0.492094862 0 kegg kegg NA NA no no no no no no Gastric acid secretion Gap junction 0.588695652 0 0.470527671 kegg kegg NA NA no no no no no no Gastric acid secretion Glucagon signaling pathway 0 0.561264822 0 kegg kegg NA NA no no no no no no Gastric acid secretion Glutathione metabolism 0 0.526679842 0 kegg kegg NA NA no no no no no no Gastric acid secretion Glycerolipid metabolism 0 -0.605731225 0 kegg kegg NA NA no no no no no up Gastric acid secretion Glycerophospholipid metabolism -0.450434783 -0.533596838 0 kegg kegg NA NA no no no no no up Gastric acid secretion Glycolysis / Gluconeogenesis 0 0.51284585 0 kegg kegg NA NA no no no no no no Gastric acid secretion Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.683794466 0 kegg kegg NA NA no no no no no no Gastric acid secretion Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.432173913 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Glyoxylate and dicarboxylate metabolism -0.412173913 -0.684782609 0 kegg kegg NA NA no no no no no no Gastric acid secretion GnRH secretion 0 -0.568181818 0 kegg kegg NA NA no no no no up up Gastric acid secretion Hematopoietic cell lineage 0 0 0.428828829 kegg kegg NA NA no no no no no no Gastric acid secretion HIF-1 signaling pathway -0.522608696 0.416996047 0 kegg kegg NA NA no no no no no no Gastric acid secretion Hippo signaling pathway 0.90173913 0.899209486 0.813642214 kegg kegg NA NA no no no no no no Gastric acid secretion Hippo signaling pathway - multiple species 0 -0.57312253 0 kegg kegg NA NA no no no no no no Gastric acid secretion Inflammatory mediator regulation of TRP channels 0 0.706521739 0 kegg kegg NA NA no no no no no no Gastric acid secretion Inositol phosphate metabolism 0 -0.556324111 0 kegg kegg NA NA no no no no no no Gastric acid secretion Insulin resistance -0.66 -0.696640316 -0.532561133 kegg kegg NA NA no no no no no no Gastric acid secretion Insulin signaling pathway -0.408695652 0.43083004 0 kegg kegg NA NA no no no no no no Gastric acid secretion JAK-STAT signaling pathway 0 -0.767786561 0 kegg kegg NA NA no no no no no no Gastric acid secretion Lachnospira 0 0.595008667 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Gastric acid secretion Leukocyte transendothelial migration 0.689565217 0.553359684 0.613384813 kegg kegg NA NA no no no no no no Gastric acid secretion Long-term depression 0.475652174 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Lysine degradation -0.546086957 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion MAPK signaling pathway 0 -0.658102767 0 kegg kegg NA NA no no no no no no Gastric acid secretion Melanogenesis 0.607826087 0.723320158 0 kegg kegg NA NA no no no no no no Gastric acid secretion Metabolism of xenobiotics by cytochrome P450 0 0.657114625 0 kegg kegg NA NA no no no no no no Gastric acid secretion Mitophagy - animal 0 0.451581028 0 kegg kegg NA NA no no no no no no Gastric acid secretion Mucin type O-glycan biosynthesis 0 -0.656126482 0 kegg kegg NA NA no no no no no no Gastric acid secretion N-Glycan biosynthesis 0 0.524703557 0 kegg kegg NA NA no no no no no no Gastric acid secretion Neurotrophin signaling pathway 0 -0.570158103 0 kegg kegg NA NA no no no no no no Gastric acid secretion NF-kappa B signaling pathway -0.633913043 -0.788537549 -0.505534106 kegg kegg NA NA no no no no no no Gastric acid secretion Nicotinate and nicotinamide metabolism 0 -0.587944664 0 kegg kegg NA NA no no no no no no Gastric acid secretion Nitrogen metabolism 0 -0.64229249 0 kegg kegg NA NA no no no no no no Gastric acid secretion NOD-like receptor signaling pathway 0 -0.78458498 0 kegg kegg NA NA no no no no no no Gastric acid secretion Non-alcoholic fatty liver disease 0 0.646245059 0.573745174 kegg kegg NA NA no no no no no no Gastric acid secretion Oscillospira 0 -0.453557312 0 LPS-producing kegg Genus NA 0.62 no no no no no no Gastric acid secretion Osteoclast differentiation 0 -0.612648221 0 kegg kegg NA NA no no no no no no Gastric acid secretion Other glycan degradation 0 -0.497035573 0 kegg kegg NA NA no no no no no no Gastric acid secretion Other types of O-glycan biosynthesis -0.473043478 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Ovarian steroidogenesis 0.66173913 0 0 kegg kegg NA NA no no no no up up Gastric acid secretion Oxidative phosphorylation 0 0.738142292 0.588931789 kegg kegg NA NA no no no no no no Gastric acid secretion Oxytocin signaling pathway 0.869565217 0.770750988 0.729214929 kegg kegg NA NA no no no no no no Gastric acid secretion p53 signaling pathway -0.679130435 -0.53458498 -0.406692407 kegg kegg NA NA no no no no no no Gastric acid secretion Pantothenate and CoA biosynthesis 0 -0.585968379 0 kegg kegg NA NA no no no no no dn Gastric acid secretion "Parathyroid hormone synthesis, secretion and action" 0 0.498023715 0 kegg kegg NA NA no no no no no no Gastric acid secretion Pentose and glucuronate interconversions 0 0.509881423 0 kegg kegg NA NA no no no no no no Gastric acid secretion Peroxisome -0.448695652 -0.669960474 0 kegg kegg NA NA no no no no no no Gastric acid secretion Phenylalanine metabolism 0.580869565 0.625494071 0.518661519 kegg kegg NA NA no no no no no no Gastric acid secretion Phospholipase D signaling pathway 0 -0.443675889 0 kegg kegg NA NA no no no no up up Gastric acid secretion Phototransduction 0 0.595849802 0 kegg kegg NA NA no no no no no no Gastric acid secretion PI3K-Akt signaling pathway -0.468695652 0 0 yes kegg kegg NA NA no no no no up up Gastric acid secretion Platelet activation 0.962608696 0.934782609 0.911969112 kegg kegg NA NA no no no no no no Gastric acid secretion Platinum drug resistance -0.697391304 -0.536561265 0 kegg kegg NA NA no no no no no no Gastric acid secretion PPAR signaling pathway 0 -0.683794466 0 kegg kegg NA NA no no no no no no Gastric acid secretion Progesterone-mediated oocyte maturation -0.608695652 -0.499011858 0 kegg kegg NA NA no no no no no no Gastric acid secretion Prolactin signaling pathway 0 -0.566205534 0 kegg kegg NA NA no no no no no no Gastric acid secretion Proteasome -0.480869565 0.469367589 0 kegg kegg NA NA no no no no no no Gastric acid secretion Protein export 0 0.567193676 0 kegg kegg NA NA no no no no no no Gastric acid secretion Protein processing in endoplasmic reticulum 0 0.432806324 0 kegg kegg NA NA no no no no no no Gastric acid secretion Proximal tubule bicarbonate reclamation 0 0.533596838 0 kegg kegg NA NA no no no no no no Gastric acid secretion Pyrimidine metabolism 0 0.479249012 -0.428056628 kegg kegg NA NA no no no no no no Gastric acid secretion Pyruvate metabolism 0 0.444664032 0 kegg kegg NA NA no no no no no no Gastric acid secretion Rap1 signaling pathway 0.854782609 0.836956522 0.854568855 kegg kegg NA NA no no no no no no Gastric acid secretion Ras signaling pathway 0 0.590909091 0 yes kegg kegg NA NA no no no no up up Gastric acid secretion Regulation of actin cytoskeleton 0.663478261 0.622529644 0.567824968 kegg kegg NA NA no no no no no no Gastric acid secretion Regulation of lipolysis in adipocytes 0.409565217 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Renin secretion 0.637391304 0.809288538 0 kegg kegg NA NA no no no no no no Gastric acid secretion Retrograde endocannabinoid signaling 0 0.746047431 0 kegg kegg NA NA no no no no no up Gastric acid secretion Ribosome 0 0.583003953 0 kegg kegg NA NA no no no no no no Gastric acid secretion Ribosome biogenesis in eukaryotes -0.487826087 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion RIG-I-like receptor signaling pathway -0.680869565 -0.82312253 -0.486743887 kegg kegg NA NA no no no no no no Gastric acid secretion RNA degradation 0 0.467391304 0 kegg kegg NA NA no no no no no no Gastric acid secretion RNA polymerase -0.556521739 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion RNA transport -0.474782609 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Salivary secretion 0.57826087 0.671936759 0 kegg kegg NA NA no no no no no no Gastric acid secretion Selenocompound metabolism -0.61826087 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Serotonergic synapse 0.476521739 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion SNARE interactions in vesicular transport -0.436521739 -0.722332016 0 kegg kegg NA NA no no no no no no Gastric acid secretion Spliceosome -0.737391304 -0.527667984 0 kegg kegg NA NA no no no no no no Gastric acid secretion Starch and sucrose metabolism 0 -0.596837945 0 kegg kegg NA NA no no no no no no Gastric acid secretion Steroid hormone biosynthesis 0 0.416996047 0 kegg kegg NA NA no no no no no no Gastric acid secretion T cell receptor signaling pathway -0.408695652 -0.814229249 -0.48005148 kegg kegg NA NA no no no no no no Gastric acid secretion Taurine and hypotaurine metabolism 0 -0.543478261 0 kegg kegg NA NA no no no no no no Gastric acid secretion TGF-beta signaling pathway 0 0.562252964 0 kegg kegg NA NA no no no no no no Gastric acid secretion Th17 cell differentiation 0 -0.443675889 0 kegg kegg NA NA no no no no no no Gastric acid secretion Thermogenesis 0 0.745059289 0.557528958 kegg kegg NA NA no no no no no no Gastric acid secretion Thiamine metabolism 0 0 -0.461776062 kegg kegg NA NA no no no no no no Gastric acid secretion Thyroid hormone signaling pathway 0.832173913 0.901185771 0.7997426 kegg kegg NA NA no no no no no no Gastric acid secretion Thyroid hormone synthesis 0 0.421936759 0 kegg kegg NA NA no no no no no no Gastric acid secretion Tight junction 0.797391304 0.827075099 0.674131274 kegg kegg NA NA no no no no no no Gastric acid secretion TNF signaling pathway -0.463478261 -0.672924901 0 kegg kegg NA NA no no no no no no Gastric acid secretion Toll-like receptor signaling pathway -0.44 -0.647233202 0 yes kegg kegg NA NA no no no no no no Gastric acid secretion Type II diabetes mellitus -0.48 -0.700592885 0 kegg kegg NA NA no no no no no no Gastric acid secretion Tyrosine metabolism 0 0.546442688 0 kegg kegg NA NA no no no no no no Gastric acid secretion Ubiquitin mediated proteolysis 0 0.482213439 0 kegg kegg NA NA no no no no no no Gastric acid secretion "Valine, leucine and isoleucine degradation" 0 0.429841897 0 kegg kegg NA NA no no no no no no Gastric acid secretion Various types of N-glycan biosynthesis -0.42 0 0 kegg kegg NA NA no no no no no no Gastric acid secretion Vascular smooth muscle contraction 0 0.812252964 0 kegg kegg NA NA no no no no no no Gastric acid secretion Vasopressin-regulated water reabsorption 0.59826087 0.739130435 0.487001287 kegg kegg NA NA no no no no no no Gastric acid secretion VEGF signaling pathway 0 -0.421936759 0 kegg kegg NA NA no no no no no no Gastric acid secretion Viral protein interaction with cytokine and cytokine receptor 0 0 0.447361647 kegg kegg NA NA no no no no no no Gastric acid secretion Wnt signaling pathway 0 0.537549407 0 kegg kegg NA NA no no no no no no Gastric cancer ABC transporters 0 0.641304348 0 kegg kegg NA NA no no no no up up Gastric cancer Acute myeloid leukemia 0.410434783 0 0 kegg kegg NA NA no no no no no no Gastric cancer AGE-RAGE signaling pathway in diabetic complications 0.572173913 0 0.486743887 kegg kegg NA NA no no no no no no Gastric cancer Alcoholism 0 -0.433794466 0 kegg kegg NA NA no no no no no no Gastric cancer Aldosterone-regulated sodium reabsorption 0.572173913 0.471343874 0.583011583 kegg kegg NA NA no no no no no no Gastric cancer Alistipes 0 0.420011194 0 kegg Genus NA 0.0114 no no no no up no Gastric cancer Amino sugar and nucleotide sugar metabolism -0.613043478 0 0 kegg kegg NA NA no no no no no no Gastric cancer Antifolate resistance 0 0.461462451 0 kegg kegg NA NA no no no no no no Gastric cancer Antigen processing and presentation -0.462608696 -0.56027668 -0.484427284 kegg kegg NA NA no no no no no no Gastric cancer Apoptosis - multiple species 0.443478261 0.59486166 0.485199485 kegg kegg NA NA no no no no no no Gastric cancer Arachidonic acid metabolism -0.50173913 0 -0.723037323 kegg kegg NA NA no no no no no no Gastric cancer Arginine and proline metabolism -0.426086957 0 -0.400514801 kegg kegg NA NA no no no no up no Gastric cancer Arginine biosynthesis 0 0 -0.447876448 kegg kegg NA NA no no no no no no Gastric cancer Autophagy - animal 0 0 0.540540541 kegg kegg NA NA no no no no no no Gastric cancer Autophagy - other 0 0.561264822 0.78043758 kegg kegg NA NA no no no no no no Gastric cancer Bacterial invasion of epithelial cells 0 -0.496047431 0 kegg kegg NA NA no no no no no no Gastric cancer Basal cell carcinoma 0.776521739 0.808300395 0.785842986 kegg kegg NA NA no no no no no no Gastric cancer Basal transcription factors 0 0 0.605405405 kegg kegg NA NA no no no no no no Gastric cancer Base excision repair 0 0.461462451 0 kegg kegg NA NA no no no no no no Gastric cancer beta-Alanine metabolism 0 -0.545454545 0 kegg kegg NA NA no no no no no no Gastric cancer Biosynthesis of amino acids -0.442608696 0 -0.64041184 kegg kegg NA NA no no no no no no Gastric cancer Biosynthesis of cofactors 0 0 -0.475160875 kegg kegg NA NA no no no no no no Gastric cancer Biosynthesis of unsaturated fatty acids 0 -0.505928854 0 kegg kegg NA NA no no no no no no Gastric cancer Breast cancer 0.66 0.602766798 0.796911197 kegg kegg NA NA no no no no no no Gastric cancer Calcium signaling pathway 0.513043478 0 0.421364221 kegg kegg NA NA no no no no up up Gastric cancer Carbohydrate digestion and absorption 0.493913043 0.744071146 0.698584299 kegg kegg NA NA no no no no no no Gastric cancer Carbon metabolism -0.472173913 -0.549407115 -0.512998713 kegg kegg NA NA no no no no no no Gastric cancer Cell cycle 0 0.45256917 0.722779923 kegg kegg NA NA no no no no no no Gastric cancer Chemical carcinogenesis - DNA adducts -0.751304348 -0.622529644 -0.437065637 kegg kegg NA NA no no no no no no Gastric cancer Chemical carcinogenesis - receptor activation 0 0.608695652 0 kegg kegg NA NA no no no no no no Gastric cancer Cholesterol metabolism 0 -0.472332016 0 yes kegg kegg NA NA no no no no no up Gastric cancer Cholinergic synapse 0 0 0.608751609 kegg kegg NA NA no no no no no no Gastric cancer Chronic myeloid leukemia 0.631304348 0.445652174 0 kegg kegg NA NA no no no no no no Gastric cancer Circadian rhythm 0.52173913 0.695652174 0.815958816 kegg kegg NA NA no no no no no no Gastric cancer Clostridium 0 -0.564418232 0 kegg Genus NA 0.925 no no no no no no Gastric cancer Collecting duct acid secretion 0 -0.649209486 -0.614414414 kegg kegg NA NA no no no no no no Gastric cancer Collinsella 0 0 -0.441037645 kegg Genus NA 0.128 no no no no no no Gastric cancer Colorectal cancer 0.730434783 0.790513834 0.852767053 kegg kegg NA NA no no no no no no Gastric cancer Complement and coagulation cascades -0.409565217 0 -0.572458172 kegg kegg NA NA no no no no no no Gastric cancer Cushing syndrome 0 0.475296443 0.442213642 kegg kegg NA NA no no no no no up Gastric cancer Drug metabolism - cytochrome P450 -0.603478261 0 0 kegg kegg NA NA no no no no no no Gastric cancer Drug metabolism - other enzymes -0.511304348 0 0 kegg kegg NA NA no no no no no no Gastric cancer EGFR tyrosine kinase inhibitor resistance 0.444347826 0 0 kegg kegg NA NA no no no no no no Gastric cancer Endocrine resistance 0.426086957 0.483201581 0 kegg kegg NA NA no no no no no no Gastric cancer Endometrial cancer 0.795652174 0.59486166 0.876962677 kegg kegg NA NA no no no no no no Gastric cancer Epstein-Barr virus infection 0 -0.482213439 0 kegg kegg NA NA no no no no no no Gastric cancer ErbB signaling pathway 0.837391304 0.828063241 0.878764479 kegg kegg NA NA no no no no no no Gastric cancer Fanconi anemia pathway 0 0 0.4996139 kegg kegg NA NA no no no no no no Gastric cancer Fat digestion and absorption -0.444347826 0 0 yes kegg kegg NA NA no no no no up up Gastric cancer Fatty acid elongation -0.437391304 -0.539525692 0 kegg kegg NA NA no no no no no no Gastric cancer Fc epsilon RI signaling pathway 0.531304348 0 0 kegg kegg NA NA no no no no no no Gastric cancer Fc gamma R-mediated phagocytosis 0 0 -0.462548263 kegg kegg NA NA no no no no no no Gastric cancer Ferroptosis 0 0 -0.623166023 kegg kegg NA NA no no no no no no Gastric cancer Focal adhesion 0 -0.432806324 0 kegg kegg NA NA no no no no up up Gastric cancer FoxO signaling pathway 0 0.492094862 0.515315315 kegg kegg NA NA no no no no no no Gastric cancer Fructose and mannose metabolism -0.431304348 0 0 kegg kegg NA NA no no no no no no Gastric cancer Gemmiger 0 0.517309848 0 butyrate-producing kegg Genus NA 0.595 no no no no no no Gastric cancer Glioma 0.606086957 0 0.752895753 kegg kegg NA NA no no no no no no Gastric cancer Glucagon signaling pathway 0 0 0.451222651 kegg kegg NA NA no no no no no no Gastric cancer Glutathione metabolism 0 0 -0.66048906 kegg kegg NA NA no no no no no no Gastric cancer Glycerolipid metabolism 0 0.592885375 0.614671815 kegg kegg NA NA no no no no no up Gastric cancer Glycerophospholipid metabolism 0.480869565 0.475296443 0.671299871 kegg kegg NA NA no no no no no up Gastric cancer "Glycine, serine and threonine metabolism" 0 0 -0.452509653 kegg kegg NA NA no no no no up no Gastric cancer Glycolysis / Gluconeogenesis -0.525217391 -0.46541502 0 kegg kegg NA NA no no no no no no Gastric cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.458498024 0 kegg kegg NA NA no no no no no no Gastric cancer Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.457509881 0.428828829 kegg kegg NA NA no no no no no no Gastric cancer Glycosaminoglycan biosynthesis - keratan sulfate 0.645217391 0.656126482 0.589189189 kegg kegg NA NA no no no no no no Gastric cancer Glycosphingolipid biosynthesis - globo and isoglobo series -0.592173913 0 0 kegg kegg NA NA no no no no no no Gastric cancer Glycosphingolipid biosynthesis - lacto and neolacto series 0.595652174 0 0.457142857 kegg kegg NA NA no no no no no no Gastric cancer Glyoxylate and dicarboxylate metabolism 0 0 -0.441184041 kegg kegg NA NA no no no no no no Gastric cancer GnRH secretion 0.79826087 0.805335968 0.836293436 kegg kegg NA NA no no no no up up Gastric cancer "Growth hormone synthesis, secretion and action" 0.519130435 0.59486166 0 kegg kegg NA NA no no no no no no Gastric cancer Hedgehog signaling pathway 0.747826087 0.590909091 0.841698842 kegg kegg NA NA no no no no no no Gastric cancer Hepatitis B 0.409565217 0 0.494465894 kegg kegg NA NA no no no no no no Gastric cancer Hepatitis C 0 0 0.43963964 kegg kegg NA NA no no no no no no Gastric cancer Homologous recombination 0 0 0.485714286 kegg kegg NA NA no no no no no no Gastric cancer Human cytomegalovirus infection 0 -0.434782609 -0.407722008 kegg kegg NA NA no no no no no dn Gastric cancer Human immunodeficiency virus 1 infection 0 -0.447628458 0 kegg kegg NA NA no no no no no no Gastric cancer Human T-cell leukemia virus 1 infection -0.417391304 -0.456521739 0 kegg kegg NA NA no no no no no no Gastric cancer Inositol phosphate metabolism 0 0.639328063 0.676962677 kegg kegg NA NA no no no no no no Gastric cancer Insulin resistance 0.510434783 0.457509881 0.581981982 kegg kegg NA NA no no no no no no Gastric cancer JAK-STAT signaling pathway 0 0.476284585 0 kegg kegg NA NA no no no no no no Gastric cancer Kaposi sarcoma-associated herpesvirus infection 0 0 -0.47027027 kegg kegg NA NA no no no no no dn Gastric cancer Leukocyte transendothelial migration 0 -0.431818182 0 kegg kegg NA NA no no no no no no Gastric cancer Long-term potentiation 0 0 0.600772201 kegg kegg NA NA no no no no no up Gastric cancer Longevity regulating pathway 0.513913043 0 0 kegg kegg NA NA no no no no no no Gastric cancer Lysine degradation 0.552173913 0.754940711 0.758815959 kegg kegg NA NA no no no no no no Gastric cancer Lysosome 0 -0.494071146 0 kegg kegg NA NA no no no no no no Gastric cancer Malaria 0 0 -0.501673102 kegg kegg NA NA no no no no no no Gastric cancer Mannose type O-glycan biosynthesis 0.764347826 0.783596838 0.733075933 kegg kegg NA NA no no no no no no Gastric cancer MAPK signaling pathway 0 0 0.665379665 kegg kegg NA NA no no no no no no Gastric cancer Melanoma 0.51826087 0.464426877 0.724581725 kegg kegg NA NA no no no no no no Gastric cancer Metabolism of xenobiotics by cytochrome P450 -0.604347826 0 0 kegg kegg NA NA no no no no no no Gastric cancer MicroRNAs in cancer 0 0 0.878764479 kegg kegg NA NA no no no no no no Gastric cancer Mineral absorption 0 0 -0.526383526 kegg kegg NA NA no no no no no no Gastric cancer mRNA surveillance pathway 0.533043478 0.453557312 0.756241956 kegg kegg NA NA no no no no no no Gastric cancer N-Glycan biosynthesis 0.480869565 0 0.618790219 kegg kegg NA NA no no no no no no Gastric cancer Necroptosis 0 0 -0.54980695 kegg kegg NA NA no no no no no no Gastric cancer Neuroactive ligand-receptor interaction -0.479130435 -0.434782609 -0.414671815 kegg kegg NA NA no no no up up up Gastric cancer Neurotrophin signaling pathway 0.430434783 0 0 kegg kegg NA NA no no no no no no Gastric cancer Neutrophil extracellular trap formation 0 0 -0.638095238 kegg kegg NA NA no no no no no no Gastric cancer Nicotine addiction 0 0.700592885 0 kegg kegg NA NA no no no no up up Gastric cancer Nitrogen metabolism 0 0 -0.402574003 kegg kegg NA NA no no no no no no Gastric cancer Non-homologous end-joining 0 -0.42687747 0 kegg kegg NA NA no no no no no no Gastric cancer Non-small cell lung cancer 0.759130435 0.812252964 0.847361647 kegg kegg NA NA no no no no no no Gastric cancer Notch signaling pathway 0.546086957 0.641304348 0.598970399 kegg kegg NA NA no no no no no no Gastric cancer Olfactory transduction 0 -0.526679842 -0.413899614 kegg kegg NA NA no no no no no no Gastric cancer One carbon pool by folate 0 0 0.420592021 kegg kegg NA NA no no no no no no Gastric cancer Oocyte meiosis 0 0 0.500643501 kegg kegg NA NA no no no no no no Gastric cancer Other glycan degradation 0 0.435770751 0.473359073 kegg kegg NA NA no no no no no no Gastric cancer Other types of O-glycan biosynthesis 0.466956522 0.721343874 0.768082368 kegg kegg NA NA no no no no no no Gastric cancer Oxytocin signaling pathway 0 -0.567193676 -0.606949807 kegg kegg NA NA no no no no no no Gastric cancer p53 signaling pathway 0.523478261 0.566205534 0.526126126 kegg kegg NA NA no no no no no no Gastric cancer Pancreatic cancer 0.61826087 0.733201581 0.607722008 kegg kegg NA NA no no no no no no Gastric cancer Pathogenic Escherichia coli infection -0.437391304 0 -0.501415701 kegg kegg NA NA no no no no no no Gastric cancer Pathways in cancer 0.564347826 0.564229249 0.589189189 kegg kegg NA NA no no no no no no Gastric cancer Pentose and glucuronate interconversions -0.493913043 0 0 kegg kegg NA NA no no no no no no Gastric cancer Pentose phosphate pathway 0 0 -0.54028314 kegg kegg NA NA no no no no no no Gastric cancer Peroxisome 0 0 -0.443500644 kegg kegg NA NA no no no no no no Gastric cancer Pertussis -0.446086957 -0.422924901 -0.47027027 kegg kegg NA NA no no no no no dn Gastric cancer Phagosome 0 0 -0.541312741 kegg kegg NA NA no no no no no no Gastric cancer Phosphatidylinositol signaling system 0.670434783 0.565217391 0.828056628 kegg kegg NA NA no no no no no no Gastric cancer Phototransduction 0 -0.657114625 0 kegg kegg NA NA no no no no no no Gastric cancer Platelet activation 0 -0.425889328 0 kegg kegg NA NA no no no no no no Gastric cancer Platinum drug resistance 0.462608696 0.709486166 0.640669241 kegg kegg NA NA no no no no no no Gastric cancer Porphyrin and chlorophyll metabolism 0 0 -0.503732304 kegg kegg NA NA no no no no no no Gastric cancer Primary bile acid biosynthesis 0 -0.58201581 0 kegg kegg NA NA no no no no no no Gastric cancer Progesterone-mediated oocyte maturation 0 0.695652174 0.839124839 kegg kegg NA NA no no no no no no Gastric cancer Prostate cancer 0.566086957 0 0.445559846 kegg kegg NA NA no no no no no no Gastric cancer Protein export 0 0 0.48030888 kegg kegg NA NA no no no no no no Gastric cancer Ras signaling pathway 0.413043478 0 0.636550837 yes kegg kegg NA NA no no no no up up Gastric cancer Regulation of actin cytoskeleton -0.62173913 -0.626482213 0 kegg kegg NA NA no no no no no no Gastric cancer Renal cell carcinoma 0.528695652 0 0 kegg kegg NA NA no no no no no no Gastric cancer Retinol metabolism -0.492173913 0 0 kegg kegg NA NA no no no no no no Gastric cancer Ribosome biogenesis in eukaryotes 0.450434783 0 0.605662806 kegg kegg NA NA no no no no no no Gastric cancer RNA degradation 0.592173913 0 0.731274131 kegg kegg NA NA no no no no no no Gastric cancer Ruminococcus 0 -0.539377583 0 kegg Genus NA 0.0679 no no no no no dn Gastric cancer Salmonella infection -0.411304348 -0.48715415 0 kegg kegg NA NA no no no no no no Gastric cancer Selenocompound metabolism 0 0.475296443 0.556756757 kegg kegg NA NA no no no no no no Gastric cancer Serotonergic synapse -0.426086957 0 -0.474903475 kegg kegg NA NA no no no no no no Gastric cancer Shigellosis 0 0 -0.52998713 kegg kegg NA NA no no no no no no Gastric cancer Signaling pathways regulating pluripotency of stem cells 0.773043478 0.910079051 0.962934363 kegg kegg NA NA no no no no no no Gastric cancer Small cell lung cancer 0.609565217 0.447628458 0 kegg kegg NA NA no no no no no up Gastric cancer Sphingolipid signaling pathway 0.435652174 0 0.576576577 kegg kegg NA NA no no no no no no Gastric cancer Spinocerebellar ataxia 0.508695652 0.660079051 0.662033462 kegg kegg NA NA no no no no no no Gastric cancer Spliceosome 0 0.688735178 0.704761905 kegg kegg NA NA no no no no no no Gastric cancer Staphylococcus aureus infection 0 -0.432806324 -0.606692407 kegg kegg NA NA no no no up no no Gastric cancer Starch and sucrose metabolism -0.493043478 0 0 kegg kegg NA NA no no no no no no Gastric cancer Steroid hormone biosynthesis -0.687826087 0 0 kegg kegg NA NA no no no no no no Gastric cancer Sulfur metabolism 0 0 -0.609009009 kegg kegg NA NA no no no no no no Gastric cancer Synaptic vesicle cycle 0 -0.500988142 0 kegg kegg NA NA no no no no up up Gastric cancer T cell receptor signaling pathway 0 0.428853755 0.598198198 kegg kegg NA NA no no no no no no Gastric cancer Taste transduction 0 0 0.692921493 kegg kegg NA NA no no no no no up Gastric cancer Taurine and hypotaurine metabolism 0.416521739 0.666007905 0.573745174 kegg kegg NA NA no no no no no no Gastric cancer Terpenoid backbone biosynthesis 0 0 0.441956242 kegg kegg NA NA no no no no no no Gastric cancer TGF-beta signaling pathway 0 0 0.584298584 kegg kegg NA NA no no no no no no Gastric cancer Tight junction -0.420869565 -0.554347826 -0.681595882 kegg kegg NA NA no no no no no no Gastric cancer Transcriptional misregulation in cancer 0 0 0.517117117 kegg kegg NA NA no no no no no no Gastric cancer Tuberculosis 0 -0.459486166 -0.44993565 kegg kegg NA NA no no no no no dn Gastric cancer Type II diabetes mellitus 0.509565217 0.640316206 0.505791506 kegg kegg NA NA no no no no no no Gastric cancer Tyrosine metabolism -0.451304348 0 0 kegg kegg NA NA no no no no no no Gastric cancer Various types of N-glycan biosynthesis 0.453043478 0 0.612870013 kegg kegg NA NA no no no no no no Gastric cancer VEGF signaling pathway 0.627826087 0.482213439 0.682368082 kegg kegg NA NA no no no no no no Gastric cancer Vibrio cholerae infection 0 0 -0.428056628 kegg kegg NA NA no no no no no no Gastric cancer Viral protein interaction with cytokine and cytokine receptor 0 -0.492094862 -0.552380952 kegg kegg NA NA no no no no no no Gastric cancer Vitamin digestion and absorption 0.452173913 0 0 kegg kegg NA NA no no no no no no Gastric cancer Wnt signaling pathway 0.569565217 0 0.759330759 kegg kegg NA NA no no no no no no Gastric cancer Yersinia infection 0 -0.434782609 0 kegg kegg NA NA no no no no no no GCA+blood 12-HEPE+blood 0 0 0.44665466 yes serum_bileacids serum_ARA 0.16 0.312 no no no no no no GCA+blood 12-ketoDCA+stool 0 0.747154558 0 yes serum_bileacids stool_bileacids 0.16 0.505 no no no no no no GCA+blood 16:0/16:0-PC+blood -0.733834586 0 0 yes serum_bileacids serum_phospholipids 0.16 0.00079 no no no no up up GCA+blood 16:0/16:0-PI+blood 0 0.490196078 0 yes serum_bileacids serum_phospholipids 0.16 0.358 no no no no no no GCA+blood 16:0/22:6-PC+blood -0.587969925 -0.539215686 0 yes serum_bileacids serum_phospholipids 0.16 4.53E-05 no no no no up up GCA+blood 16:1/16:0-PC+blood -0.490225564 -0.531862745 0 yes serum_bileacids serum_phospholipids 0.16 0.0215 no no no no up up GCA+blood 16:1/16:1-PC+blood -0.571428571 0 0 yes serum_bileacids serum_phospholipids 0.16 0.0177 no no no no no up GCA+blood 16:1/18:2-PG+blood -0.493233083 0 0 yes serum_bileacids serum_phospholipids 0.16 1.40E-08 no no no no up up GCA+blood 18:0/16:0-PC+blood 0 -0.482843137 0 yes serum_bileacids serum_phospholipids 0.16 9.64E-07 no no no up up up GCA+blood 18:0/18:1-PE+blood 0 0.512254902 0 yes serum_bileacids serum_phospholipids 0.16 0.00716 no no no up up no GCA+blood 18:0/18:2-PC+blood -0.457142857 0 0 yes serum_bileacids serum_phospholipids 0.16 1.74E-06 no no no no up up GCA+blood 18:0/22:6-PA+blood -0.467669173 0 -0.426324786 yes serum_bileacids serum_phospholipids 0.16 0.22 no no no no no no GCA+blood 18:0/22:6-PC+blood -0.470676692 0 0 yes serum_bileacids serum_phospholipids 0.16 0.0775 no no no no no up GCA+blood 18:0+blood 0 0 -0.524786325 yes serum_bileacids serum_fattyacid 0.16 0.344 no no no no no no GCA+blood 18:1/18:0-PC+blood -0.509774436 0 0 yes serum_bileacids serum_phospholipids 0.16 1.83E-06 no no no no up up GCA+blood 18:1/18:0-PS+blood -0.587969925 0 0 yes serum_bileacids serum_phospholipids 0.16 0.193 no no no no no no GCA+blood 18:1/18:2-PG+blood -0.472180451 0 0 yes serum_bileacids serum_phospholipids 0.16 5.58E-07 no no no no up up GCA+blood 18:2/16:0-PC+blood -0.518796992 0 0 yes serum_bileacids serum_phospholipids 0.16 8.67E-05 no no no no up up GCA+blood 18:3n3+blood -0.62406015 0 0 yes serum_bileacids serum_fattyacid 0.16 0.291 no no no no no no GCA+blood 20:0/20:4-PE+blood 0 0.558823529 0 yes serum_bileacids serum_phospholipids 0.16 0.00128 no no no up up no GCA+blood 20:0/20:5-PC+blood -0.506766917 0 0 yes serum_bileacids serum_phospholipids 0.16 0.882 no no no no no no GCA+blood 20:1-LPE+blood 0 -0.522058824 0 yes serum_bileacids serum_phospholipids 0.16 0.465 no no no no no no GCA+blood 20:1/20:4-PC+blood -0.485714286 -0.573529412 0 yes serum_bileacids serum_phospholipids 0.16 0.0419 no no no no no up GCA+blood 20:3/18:0-PC+blood -0.544360902 -0.546568627 0 yes serum_bileacids serum_phospholipids 0.16 0.296 no no no no no no GCA+blood 20:5/18:0-PC+blood -0.526315789 -0.659313725 0 yes serum_bileacids serum_phospholipids 0.16 3.97E-06 no no no no up up GCA+blood 22:0/16:0-PE+blood -0.484210526 -0.519607843 0 yes serum_bileacids serum_phospholipids 0.16 0.091 no no no no no up GCA+blood 22:6n3+blood 0 0 -0.447521368 yes serum_bileacids serum_fattyacid 0.16 0.792 no no no no no no GCA+blood 3-(3-Hydroxyphenyl)propanoic acid+stool -0.571428571 0 0 yes serum_bileacids stool_cometabolism 0.16 0.33 no no no no no no GCA+blood AA+blood -0.682706767 0 0 yes serum_bileacids serum_ARA 0.16 0.212 no no no no no no GCA+blood Adherens junction 0 0 0.526153846 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Adipocytokine signaling pathway 0.636842105 0 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Aldosterone synthesis and secretion 0 0.523529412 0 yes serum_bileacids kegg 0.16 NA no no no no up up GCA+blood Allograft rejection 0 -0.644117647 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Alzheimer disease 0 0 0.471538462 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Amphetamine addiction 0 0.629411765 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Amyotrophic lateral sclerosis 0 0.535294118 0.506923077 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 0.489230769 yes serum_bileacids kegg 0.16 NA no no no no up up GCA+blood Autoimmune thyroid disease 0 -0.644117647 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Bacterial invasion of epithelial cells 0 0 0.418461538 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Biosynthesis of amino acids 0 -0.529411765 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Biosynthesis of cofactors 0 0 -0.417692308 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Blautia 0 0 0.405834292 yes acetate-producing serum_bileacids Genus 0.16 1.36E-05 no no no up dn dn GCA+blood Butyricimonas 0 0 -0.401135096 yes butyrate-producing serum_bileacids Genus 0.16 0.17 no no no no no no GCA+blood CA+blood 0 0.564071228 0 yes serum_bileacids serum_bileacids 0.16 0.606 no no no no no no GCA+blood Cardiac muscle contraction 0 0 0.497692308 yes serum_bileacids kegg 0.16 NA no no no no no up GCA+blood Cell adhesion molecules 0 -0.638235294 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Cellular senescence 0 -0.661764706 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood d18:0-18:3-SM+blood -0.562406015 0 0 yes serum_bileacids serum_phospholipids 0.16 0.0879 no no no no dn no GCA+blood d18:1-14:1-SM+blood -0.497744361 0 0 yes serum_bileacids serum_phospholipids 0.16 0.0952 no no no no dn no GCA+blood d18:1-18:0-SM+blood -0.643609023 0 0 yes serum_bileacids serum_phospholipids 0.16 0.97 no no no no no no GCA+blood d18:1-18:1-SM+blood -0.596992481 0 0 yes serum_bileacids serum_phospholipids 0.16 0.916 no no no no no no GCA+blood d18:1-20:0-SM+blood -0.49924812 0 0 yes serum_bileacids serum_phospholipids 0.16 0.933 no no no no no no GCA+blood d18:1-20:1-SM+blood -0.506766917 0 0 yes serum_bileacids serum_phospholipids 0.16 0.0992 no no no no no no GCA+blood DHA+blood -0.584962406 0 0 yes serum_bileacids serum_ARA 0.16 0.872 no no no no no no GCA+blood Diabetic cardiomyopathy 0 0 0.476923077 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Endocytosis 0 -0.679411765 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood EPA+blood -0.467669173 0 0 yes serum_bileacids serum_ARA 0.16 0.212 no no no no no no GCA+blood Ferroptosis 0.542105263 0 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Focal adhesion 0 0 0.573846154 yes serum_bileacids kegg 0.16 NA no no no no up up GCA+blood GnRH signaling pathway 0 0.535294118 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Graft-versus-host disease 0 -0.644117647 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Hepatocellular carcinoma 0 0 0.532307692 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Hippo signaling pathway 0 0 0.548461538 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Human papillomavirus infection 0 -0.714705882 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Huntington disease 0 0 0.494615385 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Hypertrophic cardiomyopathy 0 0 0.469230769 yes serum_bileacids kegg 0.16 NA no no no no up up GCA+blood Kaposi sarcoma-associated herpesvirus infection 0.457894737 0 -0.416923077 yes serum_bileacids kegg 0.16 NA no no no no no dn GCA+blood Lipid and atherosclerosis 0 -0.523529412 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Longevity regulating pathway - multiple species -0.463157895 0 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Malaria 0.480701754 0 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Mineral absorption 0.645614035 0 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Mitophagy - animal 0.561403509 0.535294118 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood mTOR signaling pathway 0 0.520588235 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Natural killer cell mediated cytotoxicity 0 -0.644117647 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Necroptosis 0.680701754 0 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Oxidative phosphorylation 0 0 0.478461538 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Pancreatic cancer -0.466666667 0 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood "Parathyroid hormone synthesis, secretion and action" 0 0.55 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Pathogenic Escherichia coli infection 0 -0.523529412 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Phagosome 0 -0.561764706 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Porphyrin and chlorophyll metabolism 0 0.567647059 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Prion disease 0 0 0.502307692 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Progesterone-mediated oocyte maturation -0.552631579 0 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Ras signaling pathway -0.563157895 0 0 yes yes serum_bileacids kegg 0.16 NA no no no no up up GCA+blood Retrograde endocannabinoid signaling 0 0 0.451538462 yes serum_bileacids kegg 0.16 NA no no no no no up GCA+blood RIG-I-like receptor signaling pathway 0 0 -0.428461538 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Salmonella infection 0 0 0.425384615 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Sphingolipid signaling pathway 0 0 0.446153846 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood T cell receptor signaling pathway -0.463157895 0 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Type I diabetes mellitus 0 -0.644117647 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Ubiquitin mediated proteolysis 0.49122807 0.535294118 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Viral carcinogenesis 0 -0.647058824 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Viral myocarditis 0 -0.576470588 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+blood Viral protein interaction with cytokine and cytokine receptor -0.459649123 0 0 yes serum_bileacids kegg 0.16 NA no no no no no no GCA+stool 12-ketoDCA+stool 0 -0.609458027 0 stool_bileacids stool_bileacids 0.0809 0.505 no no no no no no GCA+stool 5-Hydroxytryptamine+stool 0.624355005 0 0 stool_bileacids stool_cometabolism 0.0809 0.00862 no no no dn dn no GCA+stool ACA+stool 0 0 -0.447802141 stool_bileacids stool_bileacids 0.0809 0.417 no no no no no no GCA+stool Adrenergic signaling in cardiomyocytes 0 -0.745454545 0 stool_bileacids kegg 0.0809 NA no no no no no up GCA+stool Aldosterone synthesis and secretion 0 -0.709090909 0 stool_bileacids kegg 0.0809 NA no no no no up up GCA+stool Allograft rejection 0 0.709090909 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Antigen processing and presentation 0 0.845454545 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Apoptosis 0.5500516 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Asthma 0 0.681818182 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Autoimmune thyroid disease 0 0.709090909 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Bacterial invasion of epithelial cells 0.564499484 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Bacteroides 0 0 -0.43083004 LPS-producing stool_bileacids Genus 0.0809 0.000267 no no no dn dn up GCA+stool Biosynthesis of amino acids 0.481940144 0.627272727 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Blautia 0 0.734265734 0 acetate-producing stool_bileacids Genus 0.0809 1.36E-05 no no no up dn dn GCA+stool CA+stool 0.607843137 0.776223776 0 stool_bileacids stool_bileacids 0.0809 0.827 no no no no no no GCA+stool Caproic acid+stool 0 -0.664335664 0 stool_bileacids stool_scfa 0.0809 0.882 no no no no no no GCA+stool Carbon metabolism 0 0.872727273 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool CDCA+stool 0.492260062 0.804195804 0 stool_bileacids stool_bileacids 0.0809 0.663 no no no no no no GCA+stool Cell adhesion molecules 0 0.727272727 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Cellular senescence 0 0.618181818 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Chemical carcinogenesis - receptor activation 0 -0.909090909 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Chemokine signaling pathway 0.578947368 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Choline metabolism in cancer 0 -0.663636364 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Clostridium 0 0.806183442 0 stool_bileacids Genus 0.0809 0.925 no no no no no no GCA+stool Cocaine addiction 0 -0.854545455 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Coronavirus disease - COVID-19 -0.494324045 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Cortisol synthesis and secretion 0 -0.927272727 0 stool_bileacids kegg 0.0809 NA no no no no no up GCA+stool Cushing syndrome 0 -0.863636364 0 stool_bileacids kegg 0.0809 NA no no no no no up GCA+stool DCA+stool 0 -0.65034965 -0.499011858 stool_bileacids stool_bileacids 0.0809 0.195 no no no no no no GCA+stool Dopaminergic synapse 0 -0.636363636 0 stool_bileacids kegg 0.0809 NA no no no no up no GCA+stool Dorea 0 0.734265734 0 stool_bileacids Genus 0.0809 0.00362 no no no up no dn GCA+stool EGFR tyrosine kinase inhibitor resistance -0.504643963 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Endocrine resistance 0 -0.945454545 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Endocytosis 0.523219814 0.736363636 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Epithelial cell signaling in Helicobacter pylori infection 0.523219814 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Epstein-Barr virus infection 0 0.754545455 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Gap junction 0 -0.8 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Gemmiger 0 0 -0.560831135 butyrate-producing stool_bileacids Genus 0.0809 0.595 no no no no no no GCA+stool Glioma 0 0 0.426312818 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Glutamatergic synapse 0 -0.790909091 0 stool_bileacids kegg 0.0809 NA no no no no up up GCA+stool Glycolysis / Gluconeogenesis 0 0.727272727 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool GnRH signaling pathway 0 -0.890909091 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Graft-versus-host disease 0 0.709090909 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool "Growth hormone synthesis, secretion and action" 0 -0.909090909 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Hematopoietic cell lineage -0.479876161 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Herpes simplex virus 1 infection 0 0.854545455 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Human cytomegalovirus infection 0 0.718181818 0 stool_bileacids kegg 0.0809 NA no no no no no dn GCA+stool Human immunodeficiency virus 1 infection 0 0.754545455 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Human papillomavirus infection 0.484004128 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Human T-cell leukemia virus 1 infection 0 0.809090909 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Inflammatory bowel disease -0.564499484 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Influenza A 0 0 -0.507622812 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Insulin secretion 0 -0.863636364 0 yes stool_bileacids kegg 0.0809 NA no no no no up up GCA+stool Intestinal immune network for IgA production -0.477812178 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool JAK-STAT signaling pathway 0 0 -0.459062676 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Lachnospira 0.661506708 0 0 butyrate-producing stool_bileacids Genus 0.0809 0.279 no no no no no no GCA+stool Leukocyte transendothelial migration 0.566563467 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Lipid and atherosclerosis 0 0.7 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Long-term depression 0 -0.627272727 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Long-term potentiation 0 0 0.587803501 stool_bileacids kegg 0.0809 NA no no no no no up GCA+stool Longevity regulating pathway 0 -0.672727273 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Longevity regulating pathway - multiple species 0 0.609090909 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Morphine addiction 0 -0.790909091 0 stool_bileacids kegg 0.0809 NA no no no no up up GCA+stool mRNA surveillance pathway -0.477812178 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Natural killer cell mediated cytotoxicity 0.529411765 0.681818182 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Neuroactive ligand-receptor interaction 0 0.709090909 0 stool_bileacids kegg 0.0809 NA no no no up up up GCA+stool Neutrophil extracellular trap formation 0.531475748 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Odoribacter 0 0.671328671 0 butyrate-producing stool_bileacids Genus 0.0809 0.798 no no no no no no GCA+stool p53 signaling pathway 0 -0.736363636 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Pancreatic secretion 0 -0.627272727 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Parabacteroides 0 0 -0.570158103 stool_bileacids Genus 0.0809 4.19E-05 no no no no up up GCA+stool Pathogenic Escherichia coli infection 0.496388029 0.627272727 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Peroxisome 0 0.654545455 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Pertussis 0 0.718181818 0 stool_bileacids kegg 0.0809 NA no no no no no dn GCA+stool Phagosome 0 0.681818182 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Proteasome -0.481940144 0.7 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Regulation of actin cytoskeleton 0 0.663636364 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Regulation of lipolysis in adipocytes 0 -0.863636364 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Rheumatoid arthritis 0 0.645454545 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Ribosome -0.519091847 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Ribosome biogenesis in eukaryotes -0.572755418 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool RNA degradation -0.535603715 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Salmonella infection 0 0.863636364 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Serotonergic synapse 0 -0.745454545 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Thyroid hormone synthesis 0 -0.727272727 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Tuberculosis 0 0.663636364 0 stool_bileacids kegg 0.0809 NA no no no no no dn GCA+stool Type I diabetes mellitus 0 0.709090909 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Viral carcinogenesis 0.601651187 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Viral myocarditis 0 0.690909091 0 stool_bileacids kegg 0.0809 NA no no no no no no GCA+stool Yersinia infection 0.537667699 0 0 stool_bileacids kegg 0.0809 NA no no no no no no GCDCA+blood 16:0/16:0-PC+blood -0.65112782 0 0 serum_bileacids serum_phospholipids 0.31 0.00079 no no no no up up GCDCA+blood 16:0/16:1-PI+blood 0.460150376 0 0 serum_bileacids serum_phospholipids 0.31 0.262 no no no no no no GCDCA+blood 16:0/18:1-PC+blood -0.515789474 0 0 serum_bileacids serum_phospholipids 0.31 6.15E-07 no no no up up up GCDCA+blood 16:0/18:2-PC+blood -0.512781955 0 0 serum_bileacids serum_phospholipids 0.31 3.24E-06 no no no no up up GCDCA+blood 16:0/20:3-PC+blood -0.463157895 0 0 serum_bileacids serum_phospholipids 0.31 5.43E-06 no no no no up up GCDCA+blood 16:0/22:6-PC+blood -0.551879699 0 0 serum_bileacids serum_phospholipids 0.31 4.53E-05 no no no no up up GCDCA+blood 16:1/16:0-PC+blood -0.622556391 0 0 serum_bileacids serum_phospholipids 0.31 0.0215 no no no no up up GCDCA+blood 16:1/16:1-PC+blood -0.678195489 0 0 serum_bileacids serum_phospholipids 0.31 0.0177 no no no no no up GCDCA+blood 16:1/18:1-PG+blood -0.502255639 0 0 serum_bileacids serum_phospholipids 0.31 3.21E-05 no no no no up up GCDCA+blood 16:1/18:2-PG+blood -0.753383459 0 0 serum_bileacids serum_phospholipids 0.31 1.40E-08 no no no no up up GCDCA+blood 18:0/16:0-PC+blood -0.523308271 0 0 serum_bileacids serum_phospholipids 0.31 9.64E-07 no no no up up up GCDCA+blood 18:0/18:0-PE+blood 0.479699248 0.509803922 0 serum_bileacids serum_phospholipids 0.31 0.00896 no no no up up no GCDCA+blood 18:0/18:1-PE+blood 0.505263158 0.583333333 0 serum_bileacids serum_phospholipids 0.31 0.00716 no no no up up no GCDCA+blood 18:0/18:2-PC+blood -0.62406015 0 0 serum_bileacids serum_phospholipids 0.31 1.74E-06 no no no no up up GCDCA+blood 18:0/20:4-PC+blood 0 -0.5 0 serum_bileacids serum_phospholipids 0.31 0.454 no no no no no no GCDCA+blood 18:0/20:4-PI+blood 0 -0.495098039 0 serum_bileacids serum_phospholipids 0.31 0.167 no no no no no no GCDCA+blood 18:0/22:6-PA+blood -0.612030075 0 -0.415384615 serum_bileacids serum_phospholipids 0.31 0.22 no no no no no no GCDCA+blood 18:0/22:6-PC+blood 0 0 -0.445470085 serum_bileacids serum_phospholipids 0.31 0.0775 no no no no no up GCDCA+blood 18:0+blood 0 0 -0.569230769 serum_bileacids serum_fattyacid 0.31 0.344 no no no no no no GCDCA+blood 18:1/16:0-PC+blood -0.547368421 0 0 serum_bileacids serum_phospholipids 0.31 2.43E-05 no no no no up up GCDCA+blood 18:1/18:0-PC+blood -0.667669173 0 0 serum_bileacids serum_phospholipids 0.31 1.83E-06 no no no no up up GCDCA+blood 18:1/18:0-PS+blood -0.741353383 0 0 serum_bileacids serum_phospholipids 0.31 0.193 no no no no no no GCDCA+blood 18:1/18:2-PG+blood -0.762406015 0 0 serum_bileacids serum_phospholipids 0.31 5.58E-07 no no no no up up GCDCA+blood 18:1/20:4-PC+blood 0 -0.600490196 0 serum_bileacids serum_phospholipids 0.31 0.582 no no no no no no GCDCA+blood 18:1/20:4-PI+blood 0 -0.524509804 0 serum_bileacids serum_phospholipids 0.31 0.192 no no no no no no GCDCA+blood 18:2-LPC+blood 0 0 0.428376068 serum_bileacids serum_phospholipids 0.31 0.00743 no no no dn no up GCDCA+blood 18:2/16:0-PC+blood -0.621052632 0 0 serum_bileacids serum_phospholipids 0.31 8.67E-05 no no no no up up GCDCA+blood 18:3n3+blood -0.584962406 0 0 serum_bileacids serum_fattyacid 0.31 0.291 no no no no no no GCDCA+blood 20:0/20:5-PC+blood -0.521804511 0 0 serum_bileacids serum_phospholipids 0.31 0.882 no no no no no no GCDCA+blood 20:1-LPA+blood -0.457142857 0 0 serum_bileacids serum_phospholipids 0.31 0.0187 no no no dn dn no GCDCA+blood 20:1-LPE+blood 0 -0.514705882 0 serum_bileacids serum_phospholipids 0.31 0.465 no no no no no no GCDCA+blood 20:1/20:4-PC+blood -0.472180451 0 -0.433846154 serum_bileacids serum_phospholipids 0.31 0.0419 no no no no no up GCDCA+blood 20:3/18:0-PC+blood -0.491729323 0 0 serum_bileacids serum_phospholipids 0.31 0.296 no no no no no no GCDCA+blood 20:4-LPE+blood 0 -0.583333333 0 serum_bileacids serum_phospholipids 0.31 0.552 no no no no no no GCDCA+blood 20:5/18:0-PC+blood -0.545864662 0 0 serum_bileacids serum_phospholipids 0.31 3.97E-06 no no no no up up GCDCA+blood 22:6n3+blood 0 0 -0.45982906 serum_bileacids serum_fattyacid 0.31 0.792 no no no no no no GCDCA+blood AA+blood -0.717293233 0 0 serum_bileacids serum_ARA 0.31 0.212 no no no no no no GCDCA+blood Adherens junction 0 0.547058824 0.599230769 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Adipocytokine signaling pathway 0.478947368 0 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood AGE-RAGE signaling pathway in diabetic complications 0 -0.547058824 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Alzheimer disease 0 0.720588235 0.596923077 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Amphetamine addiction 0 0.673529412 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Amyotrophic lateral sclerosis 0 0.785294118 0.67 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Arginine and proline metabolism 0 -0.538235294 0 serum_bileacids kegg 0.31 NA no no no no up no GCDCA+blood Arrhythmogenic right ventricular cardiomyopathy 0 0.502941176 0.559230769 serum_bileacids kegg 0.31 NA no no no no up up GCDCA+blood Autophagy - animal 0 -0.552941176 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Bacterial invasion of epithelial cells 0 0 0.461538462 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Biosynthesis of amino acids 0 -0.529411765 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Biosynthesis of cofactors 0 0 -0.413846154 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Bladder cancer 0 -0.526470588 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Blautia 0 0 0.516298064 acetate-producing serum_bileacids Genus 0.31 1.36E-05 no no no up dn dn GCDCA+blood CA+blood 0 0.511342831 0 serum_bileacids serum_bileacids 0.31 0.606 no no no no no no GCDCA+blood Cardiac muscle contraction 0 0.661764706 0.67 serum_bileacids kegg 0.31 NA no no no no no up GCDCA+blood CDCA+blood 0.598496241 0.644607843 0 serum_bileacids serum_bileacids 0.31 0.506 no no no no no no GCDCA+blood Cell adhesion molecules 0 -0.511764706 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Cellular senescence 0 -0.564705882 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Coronavirus disease - COVID-19 0 0.541176471 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood d18:1-18:0-SM+blood -0.640601504 0 0 serum_bileacids serum_phospholipids 0.31 0.97 no no no no no no GCDCA+blood d18:1-18:1-SM+blood -0.557894737 0 0 serum_bileacids serum_phospholipids 0.31 0.916 no no no no no no GCDCA+blood d18:1-20:1-SM+blood -0.563909774 0 0 serum_bileacids serum_phospholipids 0.31 0.0992 no no no no no no GCDCA+blood Diabetic cardiomyopathy 0 0.711764706 0.645384615 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Dilated cardiomyopathy 0 0 0.505384615 serum_bileacids kegg 0.31 NA no no no no up up GCDCA+blood Endocytosis 0 -0.535294118 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood ErbB signaling pathway 0 -0.541176471 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Fc epsilon RI signaling pathway 0 -0.514705882 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Fluid shear stress and atherosclerosis 0 0 0.403846154 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Focal adhesion 0 0 0.564615385 serum_bileacids kegg 0.31 NA no no no no up up GCDCA+blood FoxO signaling pathway 0 -0.547058824 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood GABAergic synapse 0 -0.588235294 0 serum_bileacids kegg 0.31 NA no no no no up up GCDCA+blood Gastric acid secretion 0 0.582352941 0.526153846 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood GCA+blood 0.831578947 0.779411765 0.764786325 yes serum_bileacids serum_bileacids 0.31 0.16 no no no no no no GCDCA+blood Hepatitis B 0 -0.567647059 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Hepatocellular carcinoma 0 0 0.64 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Hippo signaling pathway 0 0.558823529 0.602307692 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Human papillomavirus infection 0 -0.602941176 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Huntington disease 0 0.723529412 0.629230769 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Hypertrophic cardiomyopathy 0 0 0.538461538 serum_bileacids kegg 0.31 NA no no no no up up GCDCA+blood JAK-STAT signaling pathway 0 -0.523529412 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Kaposi sarcoma-associated herpesvirus infection 0 0 -0.413846154 serum_bileacids kegg 0.31 NA no no no no no dn GCDCA+blood Mitophagy - animal 0 0.670588235 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Natural killer cell mediated cytotoxicity 0 -0.532352941 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Nicotinate and nicotinamide metabolism 0 -0.535294118 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood NOD-like receptor signaling pathway 0 -0.561764706 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Non-alcoholic fatty liver disease 0 0.658823529 0.516153846 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Non-small cell lung cancer 0 -0.582352941 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood nutriCA+stool 0 0 0.493233083 serum_bileacids stool_bileacids 0.31 0.481 no no no no no no GCDCA+blood Oxidative phosphorylation 0 0.738235294 0.653846154 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Pancreatic cancer -0.477192982 0 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Parabacteroides 0 -0.5 0 serum_bileacids Genus 0.31 4.19E-05 no no no no up up GCDCA+blood Parkinson disease 0 0.714705882 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Pathways of neurodegeneration - multiple diseases 0 0.744117647 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Phenylacetic acid+stool 0 -0.618181818 0 serum_bileacids stool_cometabolism 0.31 0.785 no no no no no no GCDCA+blood Phospholipase D signaling pathway 0 -0.564705882 0 serum_bileacids kegg 0.31 NA no no no no up up GCDCA+blood Platelet activation 0 0 0.52 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Porphyrin and chlorophyll metabolism 0 0.573529412 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Prion disease 0 0.708823529 0.599230769 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Purine metabolism 0 0.588235294 -0.490769231 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Rap1 signaling pathway 0 0 0.554615385 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Ras signaling pathway -0.521052632 0 0 yes serum_bileacids kegg 0.31 NA no no no no up up GCDCA+blood Renin secretion 0 0.55 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Retrograde endocannabinoid signaling 0 0.605882353 0.577692308 serum_bileacids kegg 0.31 NA no no no no no up GCDCA+blood Ribosome 0 0.541176471 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood RIG-I-like receptor signaling pathway 0 0 -0.45 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Roseburia 0 0.571428679 0 butyrate-producing serum_bileacids Genus 0.31 0.495 no no no no no no GCDCA+blood Shigellosis 0 0.520588235 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Thermogenesis 0 0.673529412 0.522307692 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Thyroid hormone signaling pathway 0 0 0.521538462 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Ubiquitin mediated proteolysis 0 0.708823529 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Vascular smooth muscle contraction 0 0.588235294 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Vibrio cholerae infection 0 0 0.46 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+blood Viral carcinogenesis 0 -0.594117647 0 serum_bileacids kegg 0.31 NA no no no no no no GCDCA+stool 5-Hydroxytryptamine+stool 0.711042312 0 0 yes stool_bileacids stool_cometabolism 0.0471 0.00862 no dn no dn dn no GCDCA+stool Adherens junction 0.51496388 0 0 yes stool_bileacids kegg 0.0471 NA no dn no no no no GCDCA+stool Adrenergic signaling in cardiomyocytes 0 -0.609090909 0.533596838 yes stool_bileacids kegg 0.0471 NA no dn no no no up GCDCA+stool Aldosterone synthesis and secretion 0 0 0.471485037 yes stool_bileacids kegg 0.0471 NA no dn no no up up GCDCA+stool Amphetamine addiction 0 0 0.476002259 yes stool_bileacids kegg 0.0471 NA no dn no no no no GCDCA+stool Arrhythmogenic right ventricular cardiomyopathy 0.521155831 0 0 yes stool_bileacids kegg 0.0471 NA no dn no no up up GCDCA+stool Bacterial invasion of epithelial cells 0.539731682 0 0 yes stool_bileacids kegg 0.0471 NA no dn no no no no GCDCA+stool CDCA+stool 0 0.811188811 0 yes stool_bileacids stool_bileacids 0.0471 0.663 no dn no no no no GCDCA+stool Chemokine signaling pathway 0.5500516 0 0 yes stool_bileacids kegg 0.0471 NA no dn no no no no GCDCA+stool Coprococcus 0 0 -0.456521739 yes butyrate-producing stool_bileacids Genus 0.0471 0.612 no dn no no no no GCDCA+stool Dorea 0 0.622377622 0 yes stool_bileacids Genus 0.0471 0.00362 no dn no up no dn GCDCA+stool Faecalibacterium 0 0.65034965 0 yes butyrate-producing stool_bileacids Genus 0.0471 0.0039 no dn no no dn dn GCDCA+stool Focal adhesion 0.484004128 0 0 yes stool_bileacids kegg 0.0471 NA no dn no no up up GCDCA+stool GCA+stool 0.851393189 0.636363636 0.767786561 yes stool_bileacids stool_bileacids 0.0471 0.0809 no dn no no no no GCDCA+stool Glucagon signaling pathway 0 0 0.501976285 yes stool_bileacids kegg 0.0471 NA no dn no no no no GCDCA+stool Hepatocellular carcinoma 0.506707946 0 0 yes stool_bileacids kegg 0.0471 NA no dn no no no no GCDCA+stool Hypertrophic cardiomyopathy 0.473684211 0 0 yes stool_bileacids kegg 0.0471 NA no dn no no up up GCDCA+stool Intestinal immune network for IgA production 0 0.609090909 0 yes stool_bileacids kegg 0.0471 NA no dn no no no no GCDCA+stool Kaposi sarcoma-associated herpesvirus infection 0 0.618181818 0 yes stool_bileacids kegg 0.0471 NA no dn no no no dn GCDCA+stool Lachnospira 0.63880289 0 0 yes butyrate-producing stool_bileacids Genus 0.0471 0.279 no dn no no no no GCDCA+stool Leukocyte transendothelial migration 0.568627451 0 0 yes stool_bileacids kegg 0.0471 NA no dn no no no no GCDCA+stool Long-term potentiation 0 0 0.56295878 yes stool_bileacids kegg 0.0471 NA no dn no no no up GCDCA+stool mRNA surveillance pathway 0 0 0.451157538 yes stool_bileacids kegg 0.0471 NA no dn no no no no GCDCA+stool Oxytocin signaling pathway 0.484004128 0 0 yes stool_bileacids kegg 0.0471 NA no dn no no no no GCDCA+stool Proteasome -0.531475748 0 0 yes stool_bileacids kegg 0.0471 NA no dn no no no no GCDCA+stool Rap1 signaling pathway 0.519091847 0 0 yes stool_bileacids kegg 0.0471 NA no dn no no no no GCDCA+stool Ribosome biogenesis in eukaryotes -0.502579979 0 0 yes stool_bileacids kegg 0.0471 NA no dn no no no no GCDCA+stool Roseburia 0 0.847637027 0 yes butyrate-producing stool_bileacids Genus 0.0471 0.495 no dn no no no no GCDCA+stool Vibrio cholerae infection 0.498452012 0 0 yes stool_bileacids kegg 0.0471 NA no dn no no no no GDCA+blood 11-HETE+blood 0 -0.519087249 0 serum_bileacids serum_ARA 0.632 0.464 no no no no no no GDCA+blood 12-HEPE+blood 0.452339196 0 0 serum_bileacids serum_ARA 0.632 0.312 no no no no no no GDCA+blood 12-ketoDCA+blood 0.624875696 0.523615897 0.418325484 serum_bileacids serum_bileacids 0.632 0.517 no no no no no no GDCA+blood 12-ketoDCA+stool 0.681318681 0 0 serum_bileacids stool_bileacids 0.632 0.505 no no no no no no GDCA+blood 14:0-LPC+blood 0 0.553921569 0 serum_bileacids serum_phospholipids 0.632 0.00689 no no no up up no GDCA+blood 14:0/16:0-PC+blood 0.527819549 0 0 serum_bileacids serum_phospholipids 0.632 0.0358 no no no no up no GDCA+blood 16:0/16:0-PC+blood 0 -0.514705882 0 serum_bileacids serum_phospholipids 0.632 0.00079 no no no no up up GDCA+blood 16:0/18:0-PS+blood 0 -0.536764706 0 serum_bileacids serum_phospholipids 0.632 0.377 no no no no no no GDCA+blood 16:1/18:1-PG+blood 0 -0.56372549 0 serum_bileacids serum_phospholipids 0.632 3.21E-05 no no no no up up GDCA+blood 18:0/18:0-PC+blood 0 -0.651960784 0 serum_bileacids serum_phospholipids 0.632 0.426 no no no no no no GDCA+blood 18:0/18:0-PS+blood 0 -0.546568627 0 serum_bileacids serum_phospholipids 0.632 0.00617 no no no no up no GDCA+blood 18:0/18:1-PC+blood 0 -0.632352941 0 serum_bileacids serum_phospholipids 0.632 0.393 no no no no no no GDCA+blood 18:0/18:1-PI+blood 0 -0.495098039 0 serum_bileacids serum_phospholipids 0.632 0.599 no no no no no no GDCA+blood 18:0/22:6-PA+blood 0 -0.666666667 0 serum_bileacids serum_phospholipids 0.632 0.22 no no no no no no GDCA+blood 18:0/22:6-PC+blood 0 -0.50245098 0 serum_bileacids serum_phospholipids 0.632 0.0775 no no no no no up GDCA+blood 18:0/22:6-PI+blood 0 -0.544117647 0 serum_bileacids serum_phospholipids 0.632 0.425 no no no no no no GDCA+blood 18:1/18:1-PG+blood 0 -0.50245098 0 serum_bileacids serum_phospholipids 0.632 0.00352 no no no no up up GDCA+blood 18:2/18:1-PC+blood -0.563909774 0 0 serum_bileacids serum_phospholipids 0.632 2.30E-05 no no no dn up up GDCA+blood 18:2/18:2-PC+blood -0.554887218 0 0 serum_bileacids serum_phospholipids 0.632 1.98E-05 no no no dn up up GDCA+blood 18:2n6c+blood -0.464661654 0 0 serum_bileacids serum_fattyacid 0.632 0.15 no no no no no no GDCA+blood 18:3-LPC+blood -0.484210526 0 0 serum_bileacids serum_phospholipids 0.632 0.147 no no no no no no GDCA+blood 20:1/20:4-PC+blood 0 -0.571078431 0 serum_bileacids serum_phospholipids 0.632 0.0419 no no no no no up GDCA+blood 5-HETE+blood 0 -0.621313915 0 serum_bileacids serum_ARA 0.632 0.697 no no no no no no GDCA+blood 8-HETE+blood -0.533834586 0 0 serum_bileacids serum_ARA 0.632 0.741 no no no no no no GDCA+blood Adherens junction -0.473684211 0 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Adipocytokine signaling pathway 0 0.517647059 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Anaerostipes 0 -0.571426844 0 butyrate-producing serum_bileacids Genus 0.632 0.568 no no no no no no GDCA+blood Apelin signaling pathway 0 0 -0.437692308 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Asthma 0 -0.635294118 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood cAMP signaling pathway 0 0.6 0 yes serum_bileacids kegg 0.632 NA no no no no up up GDCA+blood CDCA+stool 0 -0.745454545 0 serum_bileacids stool_bileacids 0.632 0.663 no no no no no no GDCA+blood Clostridium 0 -0.622220341 0 serum_bileacids Genus 0.632 0.925 no no no no no no GDCA+blood Coronavirus disease - COVID-19 0 0 -0.521538462 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood d18:1-18:1-SM+blood 0 0 -0.411282051 serum_bileacids serum_phospholipids 0.632 0.916 no no no no no no GDCA+blood d18:1-20:1-SM+blood 0 0 -0.458461538 serum_bileacids serum_phospholipids 0.632 0.0992 no no no no no no GDCA+blood DCA+stool 0.752747253 0 0.45112782 serum_bileacids stool_bileacids 0.632 0.195 no no no no no no GDCA+blood EGFR tyrosine kinase inhibitor resistance 0 0 -0.413076923 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Endocrine resistance 0 0.579411765 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Fc epsilon RI signaling pathway 0 0 0.45 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Fluid shear stress and atherosclerosis -0.456140351 0 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood FoxO signaling pathway 0 0 0.539230769 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood GCA+blood 0 0 0.45982906 yes serum_bileacids serum_bileacids 0.632 0.16 no no no no no no GDCA+blood GCA+stool 0 -0.636363636 0 serum_bileacids stool_bileacids 0.632 0.0809 no no no no no no GDCA+blood GnRH signaling pathway 0 0.582352941 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood "Growth hormone synthesis, secretion and action" 0 0.694117647 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Hematopoietic cell lineage 0 -0.576470588 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Hippo signaling pathway 0 -0.541176471 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Influenza A -0.49122807 0 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood JAK-STAT signaling pathway 0 0 0.595384615 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Kaposi sarcoma-associated herpesvirus infection 0 0 -0.427692308 serum_bileacids kegg 0.632 NA no no no no no dn GDCA+blood L-Phenylalanine+stool -0.708791209 0 0 serum_bileacids stool_cometabolism 0.632 0.398 no no no no no no GDCA+blood L-Tryptophan+stool -0.692307692 0 0 serum_bileacids stool_cometabolism 0.632 0.557 no no no no no no GDCA+blood L-Tyrosine+stool -0.725274725 0 0 serum_bileacids stool_cometabolism 0.632 0.44 no no no no no no GDCA+blood LCA+stool 0 0 0.469172932 serum_bileacids stool_bileacids 0.632 0.314 no no no no no no GDCA+blood Leukocyte transendothelial migration -0.470175439 0 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Long-term depression 0 0.629411765 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Longevity regulating pathway 0 0.579411765 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Longevity regulating pathway - multiple species 0 -0.5 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Malaria 0 0.591176471 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Mitophagy - animal 0 0 -0.402307692 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood mTOR signaling pathway 0 0 -0.414615385 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Neuroactive ligand-receptor interaction 0 0 0.403076923 serum_bileacids kegg 0.632 NA no no no up up up GDCA+blood Pathogenic Escherichia coli infection -0.49122807 0 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Prevotella 0 0.563807819 0 acetate-producing serum_bileacids Genus 0.632 0.287 no no no no no no GDCA+blood Prolactin signaling pathway 0 0 0.446153846 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Proteasome 0 -0.55 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Purine metabolism 0.463157895 0 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Rap1 signaling pathway -0.50877193 0 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Regulation of actin cytoskeleton 0 -0.502941176 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Relaxin signaling pathway 0 0.505882353 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Ribosome 0 0 -0.521538462 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Sphingolipid signaling pathway 0 0 0.507692308 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood UDCA+stool 0 -0.736363636 0 serum_bileacids stool_bileacids 0.632 0.266 no no no no no no GDCA+blood Vascular smooth muscle contraction 0 0 -0.426153846 serum_bileacids kegg 0.632 NA no no no no no no GDCA+blood Yersinia infection -0.584210526 0 0 serum_bileacids kegg 0.632 NA no no no no no no GDCA+stool Alistipes -0.494568625 0 0 stool_bileacids Genus 0.656 0.0114 no no no no up no GDCA+stool Amphetamine addiction -0.472896294 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Asthma 0 0.678817251 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Blautia 0 0.619965924 0 acetate-producing stool_bileacids Genus 0.656 1.36E-05 no no no up dn dn GDCA+stool CA+stool 0.585441482 0.812610703 0 stool_bileacids stool_bileacids 0.656 0.827 no no no no no no GDCA+stool Carbon metabolism 0 0.605924123 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool CDCA+stool 0 0.809108071 0 stool_bileacids stool_bileacids 0.656 0.663 no no no no no no GDCA+stool Chemical carcinogenesis - receptor activation 0 -0.651482328 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Chemokine signaling pathway 0.484254066 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Clostridium 0 0.633976454 0 stool_bileacids Genus 0.656 0.925 no no no no no no GDCA+stool Coronavirus disease - COVID-19 -0.535880299 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Cortisol synthesis and secretion 0 -0.651482328 0 stool_bileacids kegg 0.656 NA no no no no no up GDCA+stool DCA+stool 0 0 -0.436201994 stool_bileacids stool_bileacids 0.656 0.195 no no no no no no GDCA+stool Dorea 0 0.67250541 0 stool_bileacids Genus 0.656 0.00362 no no no up no dn GDCA+stool Epithelial cell signaling in Helicobacter pylori infection 0.509034657 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Ferroptosis -0.473928819 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool GABAergic synapse 0.517294855 0 0 stool_bileacids kegg 0.656 NA no no no no up up GDCA+stool Gap junction 0 -0.642370687 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool GCA+stool 0.488384164 0.65849488 0.636004268 stool_bileacids stool_bileacids 0.656 0.0809 no no no no no no GDCA+stool GCDCA+stool 0 0.711034365 0.852621584 yes stool_bileacids stool_bileacids 0.656 0.0471 no no no no dn no GDCA+stool Glutamatergic synapse 0 -0.66970561 0 stool_bileacids kegg 0.656 NA no no no no up up GDCA+stool Glycolysis / Gluconeogenesis 0 0.67426143 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool "Growth hormone synthesis, secretion and action" 0 -0.687928892 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Hematopoietic cell lineage 0 0.651482328 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Inflammatory mediator regulation of TRP channels -0.504904559 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Legionellosis 0.525555052 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Lipid and atherosclerosis 0.503872034 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Longevity regulating pathway 0 -0.615035764 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Melanogenesis -0.498709411 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Mineral absorption -0.589571581 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Necroptosis -0.549303119 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool NOD-like receptor signaling pathway 0.51626233 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Proteasome 0 0.646926508 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Ribosome -0.56066089 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Roseburia -0.558595841 0 0 butyrate-producing stool_bileacids Genus 0.656 0.495 no no no no no no GDCA+stool Serotonergic synapse 0 -0.605924123 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Th1 and Th2 cell differentiation 0 0.610479944 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Thyroid hormone synthesis -0.503872034 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool Ubiquitin mediated proteolysis -0.48735164 0 0 stool_bileacids kegg 0.656 NA no no no no no no GDCA+stool ¦Ø-MCA+stool 0 0.70304991 0 stool_bileacids stool_bileacids 0.656 0.919 no no no no no no Gemmiger Anaerotruncus -0.411815359 0 0 butyrate-producing Genus Genus 0.595 0.904 no no no no no no Gemmiger Eggerthella -0.625999253 0 0 butyrate-producing Genus Genus 0.595 0.912 no no no no no no GGT+clinic 16:0/16:0-PC+blood -0.545923633 0 0 clinic serum_phospholipids 0.00149 0.00079 up up no no up up GGT+clinic 16:0/18:0-PS+blood 0 0 -0.406153846 clinic serum_phospholipids 0.00149 0.377 up up no no no no GGT+clinic 16:0/18:2-PI+blood 0 0.664285714 0 clinic serum_phospholipids 0.00149 0.269 up up no no no no GGT+clinic 16:0/18:3-PC+blood -0.581011352 0 0 clinic serum_phospholipids 0.00149 0.00216 up up no no up up GGT+clinic 16:0/22:6-PC+blood 0 -0.635714286 0 clinic serum_phospholipids 0.00149 4.53E-05 up up no no up up GGT+clinic 18:0/18:1-PE+blood 0 0.542857143 0 clinic serum_phospholipids 0.00149 0.00716 up up no up up no GGT+clinic 18:0/20:2-PC+blood 0 0 0.417692308 clinic serum_phospholipids 0.00149 0.733 up up no no no no GGT+clinic 18:0/20:4-PC+blood 0 -0.635714286 0 clinic serum_phospholipids 0.00149 0.454 up up no no no no GGT+clinic 18:0/20:5-PC+blood 0 -0.65 0 clinic serum_phospholipids 0.00149 0.17 up up no no no no GGT+clinic 18:0/22:6-PA+blood 0 -0.532142857 0 clinic serum_phospholipids 0.00149 0.22 up up no no no no GGT+clinic 18:0/22:6-PC+blood 0 -0.582142857 0 clinic serum_phospholipids 0.00149 0.0775 up up no no no up GGT+clinic 18:1-LPC+blood 0 0 0.631538462 clinic serum_phospholipids 0.00149 0.179 up up no no no no GGT+clinic 18:1-LPE+blood 0 0 0.493076923 clinic serum_phospholipids 0.00149 0.117 up up no no no no GGT+clinic 18:1/18:1-PE+blood 0 0.564285714 0 clinic serum_phospholipids 0.00149 1.03E-05 up up no up up no GGT+clinic 18:1/18:2-PI+blood 0 0 0.533846154 clinic serum_phospholipids 0.00149 0.0164 up up no dn no up GGT+clinic 18:1/20:4-PC+blood 0 -0.664285714 0 clinic serum_phospholipids 0.00149 0.582 up up no no no no GGT+clinic 18:2-LPC+blood 0 0 0.57 clinic serum_phospholipids 0.00149 0.00743 up up no dn no up GGT+clinic 18:2/18:1-PC+blood 0 0 0.405384615 clinic serum_phospholipids 0.00149 2.30E-05 up up no dn up up GGT+clinic 18:2/18:2-PC+blood 0 0 0.402307692 clinic serum_phospholipids 0.00149 1.98E-05 up up no dn up up GGT+clinic 18:2/20:4-PC+blood 0 0 0.432307692 clinic serum_phospholipids 0.00149 0.0145 up up no no no up GGT+clinic 20:0/20:5-PC+blood 0 -0.528571429 0 clinic serum_phospholipids 0.00149 0.882 up up no no no no GGT+clinic 20:3/18:0-PC+blood -0.502579979 -0.553571429 0 clinic serum_phospholipids 0.00149 0.296 up up no no no no GGT+clinic 20:5/18:0-PC+blood 0 -0.617857143 0 clinic serum_phospholipids 0.00149 3.97E-06 up up no no up up GGT+clinic 22:6n3+blood 0 -0.553571429 0 clinic serum_fattyacid 0.00149 0.792 up up no no no no GGT+clinic Aldosterone synthesis and secretion 0.436476567 0 0 clinic kegg 0.00149 NA up up no no up up GGT+clinic Amphetamine addiction 0.43083004 0 0 clinic kegg 0.00149 NA up up no no no no GGT+clinic Anaerostipes -0.483447244 0 0 butyrate-producing clinic Genus 0.00149 0.568 up up no no no no GGT+clinic Antigen processing and presentation -0.476002259 0 0 clinic kegg 0.00149 NA up up no no no no GGT+clinic Butyric acid+stool 0.523529412 0 0 yes clinic stool_scfa 0.00149 0.102 up up no dn no no GGT+clinic Cushing syndrome 0.531338227 0 0 clinic kegg 0.00149 NA up up no no no up GGT+clinic d18:1-18:1-SM+blood -0.59752322 0 0 clinic serum_phospholipids 0.00149 0.916 up up no no no no GGT+clinic d18:1-20:0-SM+blood -0.531475748 0 0 clinic serum_phospholipids 0.00149 0.933 up up no no no no GGT+clinic d18:1-20:1-SM+blood -0.477812178 0 0 clinic serum_phospholipids 0.00149 0.0992 up up no no no no GGT+clinic DCA+stool 0 0 -0.424054207 clinic stool_bileacids 0.00149 0.195 up up no no no no GGT+clinic Dorea -0.541501976 0.507201376 0 clinic Genus 0.00149 0.00362 up up no up no dn GGT+clinic Eotaxin 0.653846154 -0.501754386 0 clinic serum_cytokines 0.00149 0.393 up up no no no no GGT+clinic EPA+blood 0 -0.578571429 -0.414615385 clinic serum_ARA 0.00149 0.212 up up no no no no GGT+clinic GCA+blood 0.593395253 0 0 yes clinic serum_bileacids 0.00149 0.16 up up no no no no GGT+clinic GCDCA+blood 0 0.564285714 0 clinic serum_bileacids 0.00149 0.31 up up no no no no GGT+clinic Glucagon signaling pathway 0.452286844 0 0 clinic kegg 0.00149 NA up up no no no no GGT+clinic HDCA+stool 0.635294118 0 -0.568605308 clinic stool_bileacids 0.00149 0.176 up up no no no no GGT+clinic Herpes simplex virus 1 infection -0.496329757 0 0 clinic kegg 0.00149 NA up up no no no no GGT+clinic Human cytomegalovirus infection -0.424054207 0 0 clinic kegg 0.00149 NA up up no no no dn GGT+clinic Human T-cell leukemia virus 1 infection -0.499717674 0 0 clinic kegg 0.00149 NA up up no no no no GGT+clinic IL-17 signaling pathway -0.431959345 0 0 clinic kegg 0.00149 NA up up no no no no GGT+clinic IL-9 -0.813186813 0 0 clinic serum_cytokines 0.00149 0.906 up up no no no no GGT+clinic Kaposi sarcoma-associated herpesvirus infection 0 0.433766234 0 clinic kegg 0.00149 NA up up no no no dn GGT+clinic L-2-Aminobutyric acid+blood 0 -0.542857143 0 yes clinic serum_aminoacids 0.00149 0.000328 up up no up up no GGT+clinic L-Alanine+blood 0.578947368 0 0 yes clinic serum_aminoacids 0.00149 0.00138 up up no up up no GGT+clinic L-Asparagine+blood 0.475748194 0 0 clinic serum_aminoacids 0.00149 0.784 up up no no no no GGT+clinic L-Glutamic acid+blood 0.593395253 0 0 yes clinic serum_aminoacids 0.00149 6.20E-05 up up no up up no GGT+clinic L-Ornithine+blood 0.469556244 0 0 clinic serum_aminoacids 0.00149 0.175 up up no no no no GGT+clinic L-Proline+blood 0 0.817857143 0 yes clinic serum_aminoacids 0.00149 0.00265 up up no up up no GGT+clinic MCP-1(MCAF) 0.736263736 0 0 yes clinic serum_cytokines 0.00149 0.0633 up up no dn no no GGT+clinic Melanogenesis 0.46809712 0 0 clinic kegg 0.00149 NA up up no no no no GGT+clinic Mineral absorption 0.481648786 0 0 clinic kegg 0.00149 NA up up no no no no GGT+clinic Mitophagy - animal 0 0.448051948 0 clinic kegg 0.00149 NA up up no no no no GGT+clinic Necroptosis 0.547148504 0 0 clinic kegg 0.00149 NA up up no no no no GGT+clinic PAI-1 0 0.447769622 0 yes clinic DM-assocaited hormones 0.00149 5.10E-05 up up no up up up GGT+clinic Prolactin signaling pathway 0 0 -0.400280112 clinic kegg 0.00149 NA up up no no no no GGT+clinic Roseburia 0 0.435470224 0 butyrate-producing clinic Genus 0.00149 0.495 up up no no no no GGT+clinic Ruminococcus -0.420064761 0.43941286 0 clinic Genus 0.00149 0.0679 up up no no no dn GGT+clinic TCA+stool 0 0.710707994 0 clinic stool_bileacids 0.00149 0.458 up up no no no no GGT+clinic TLCA+stool -0.623950099 0 0 clinic stool_bileacids 0.00149 0.243 up up no no no no GGT+clinic TMAO+blood 0 -0.557142857 0 clinic serum_choline 0.00149 0.00706 up up no up up no GGT+clinic Transcriptional misregulation in cancer -0.43083004 0 0 clinic kegg 0.00149 NA up up no no no no GGT+clinic TXB2+blood 0 -0.636275835 0 yes clinic serum_ARA 0.00149 0.0644 up up no dn no no GIP C-peptide 0 -0.633043478 0 DM-assocaited hormones DM-assocaited hormones 0.374 0.228 no no no no no no GLCA+blood 12-ketoDCA+blood 0 0.658504608 0.495473029 serum_bileacids serum_bileacids 0.319 0.517 no no no no no no GLCA+blood "12,13-EPOME+blood" 0 0 0.467574779 serum_bileacids serum_ARA 0.319 0.901 no no no no no no GLCA+blood 14:0-LPC+blood 0 0 -0.403474386 serum_bileacids serum_phospholipids 0.319 0.00689 no no no up up no GLCA+blood 14:0/16:0-PC+blood 0 0 -0.492177152 serum_bileacids serum_phospholipids 0.319 0.0358 no no no no up no GLCA+blood 14:0/18:2-PC+blood 0 0 -0.451521717 serum_bileacids serum_phospholipids 0.319 0.102 no no no no up no GLCA+blood 14:0/20:4-PC+blood 0 0 -0.407170335 serum_bileacids serum_phospholipids 0.319 0.486 no no no no no no GLCA+blood 16:0/18:1-PC+blood 0 -0.560112034 0 serum_bileacids serum_phospholipids 0.319 6.15E-07 no no no up up up GLCA+blood 16:0/18:2-PC+blood 0 -0.525105032 0 serum_bileacids serum_phospholipids 0.319 3.24E-06 no no no no up up GLCA+blood 16:0/18:3-PC+blood 0 0 -0.451521717 serum_bileacids serum_phospholipids 0.319 0.00216 no no no no up up GLCA+blood 16:0/20:3-PC+blood 0 0 -0.419490163 serum_bileacids serum_phospholipids 0.319 5.43E-06 no no no no up up GLCA+blood 16:0+blood 0 -0.555736158 -0.413330249 yes serum_bileacids serum_fattyacid 0.319 0.00876 no no no up no no GLCA+blood 16:1-LPC+blood 0 0 -0.437969906 serum_bileacids serum_phospholipids 0.319 0.0241 no no no no up no GLCA+blood 16:1/16:0-PC+blood 0 -0.485722154 0 serum_bileacids serum_phospholipids 0.319 0.0215 no no no no up up GLCA+blood 16:1/18:2-PG+blood 0 -0.525105032 0 serum_bileacids serum_phospholipids 0.319 1.40E-08 no no no no up up GLCA+blood 16:1+blood 0 -0.485722154 0 yes serum_bileacids serum_fattyacid 0.319 0.0186 no no no no no dn GLCA+blood 18:0/16:0-PC+blood 0 -0.555736158 0 serum_bileacids serum_phospholipids 0.319 9.64E-07 no no no up up up GLCA+blood 18:0/20:3-PC+blood 0 0 -0.494641117 serum_bileacids serum_phospholipids 0.319 0.0682 no no no no up no GLCA+blood 18:1/16:0-PC+blood 0 -0.560112034 0 serum_bileacids serum_phospholipids 0.319 2.43E-05 no no no no up up GLCA+blood 18:1/18:1-PC+blood 0 0 -0.467537495 serum_bileacids serum_phospholipids 0.319 1.34E-05 no no no no up up GLCA+blood 18:1/20:4-PE+blood 0 0 0.442897837 serum_bileacids serum_phospholipids 0.319 0.0578 no no no up no no GLCA+blood 18:1/22:6-PE+blood 0 -0.516353281 0 serum_bileacids serum_phospholipids 0.319 0.0047 no no no no up no GLCA+blood 18:1+blood 0 -0.516353281 0 yes serum_bileacids serum_fattyacid 0.319 0.00202 no no no up no dn GLCA+blood 18:2/16:0-PC+blood 0 -0.485722154 0 serum_bileacids serum_phospholipids 0.319 8.67E-05 no no no no up up GLCA+blood 20:0-LPC+blood 0 0.485722154 0 serum_bileacids serum_phospholipids 0.319 0.199 no no no no no no GLCA+blood 20:1-LPE+blood 0 0 -0.420722146 serum_bileacids serum_phospholipids 0.319 0.465 no no no no no no GLCA+blood 20:2/18:0-PC+blood 0 0 -0.509424912 serum_bileacids serum_phospholipids 0.319 0.0427 no no no no up no GLCA+blood 20:2+blood -0.446649911 0 0 serum_bileacids serum_fattyacid 0.319 0.478 no no no no no no GLCA+blood 20:3-LPC+blood 0 0 -0.42688206 serum_bileacids serum_phospholipids 0.319 0.0292 no no no no up no GLCA+blood 20:3n6+blood 0 0 -0.476161375 serum_bileacids serum_fattyacid 0.319 0.0884 no no no up no no GLCA+blood 20:4-LPE+blood 0.450602565 0 0 serum_bileacids serum_phospholipids 0.319 0.552 no no no no no no GLCA+blood 22:6-LPC+blood -0.517797684 0 0 serum_bileacids serum_phospholipids 0.319 0.127 no no no no no up GLCA+blood 24:0+blood 0 0 -0.414562232 serum_bileacids serum_fattyacid 0.319 0.034 no no no dn no up GLCA+blood 5-HETE+blood 0 -0.5367422 0 serum_bileacids serum_ARA 0.319 0.697 no no no no no no GLCA+blood Akkermansia -0.633494611 0 0 acetate-producing serum_bileacids Genus 0.319 0.23 no no no no no no GLCA+blood Aldosterone synthesis and secretion -0.457176242 0 0 serum_bileacids kegg 0.319 NA no no no no up up GLCA+blood Biosynthesis of cofactors 0 0 -0.439334972 serum_bileacids kegg 0.319 NA no no no no no no GLCA+blood Blautia 0 -0.525105032 0 acetate-producing serum_bileacids Genus 0.319 1.36E-05 no no no up dn dn GLCA+blood Circadian entrainment -0.516020709 0 0 serum_bileacids kegg 0.319 NA no no no no up up GLCA+blood Colorectal cancer 0 0 0.418900787 serum_bileacids kegg 0.319 NA no no no no no no GLCA+blood Creatinine+blood 0 -0.516353281 0 serum_bileacids serum_choline 0.319 0.437 no no no no no no GLCA+blood Cystine+blood 0 -0.490098029 0 yes serum_bileacids serum_aminoacids 0.319 0.00028 no no no up up no GLCA+blood Focal adhesion 0 0 0.462493715 serum_bileacids kegg 0.319 NA no no no no up up GLCA+blood FoxO signaling pathway 0 0 0.40119116 serum_bileacids kegg 0.319 NA no no no no no no GLCA+blood Gap junction -0.659737003 0 0 serum_bileacids kegg 0.319 NA no no no no no no GLCA+blood Gemmiger 0.51384503 0 0 butyrate-producing serum_bileacids Genus 0.319 0.595 no no no no no no GLCA+blood Glutamatergic synapse -0.608813907 0 0 serum_bileacids kegg 0.319 NA no no no no up up GLCA+blood "Glycine, serine and threonine metabolism" 0 0 -0.408002555 serum_bileacids kegg 0.319 NA no no no no up no GLCA+blood GnRH signaling pathway -0.521678831 0 0 serum_bileacids kegg 0.319 NA no no no no no no GLCA+blood LCA+stool 0 0 0.457488141 serum_bileacids stool_bileacids 0.319 0.314 no no no no no no GLCA+blood Leukocyte transendothelial migration 0 0 0.427074461 serum_bileacids kegg 0.319 NA no no no no no no GLCA+blood Porphyrin and chlorophyll metabolism 0 0 -0.439334972 serum_bileacids kegg 0.319 NA no no no no no no GLCA+blood Prevotella 0.684712472 0 0 serum_bileacids Genus 0.319 0.367 no no no no no no GLCA+blood Salivary secretion -0.737819084 0 0 serum_bileacids kegg 0.319 NA no no no no no no GLCA+blood Salmonella infection 0 0 0.419581927 serum_bileacids kegg 0.319 NA no no no no no no GLCA+blood Serotonergic synapse -0.504704466 0 0 serum_bileacids kegg 0.319 NA no no no no no no GLCA+blood Sphingolipid signaling pathway 0 0 0.508130061 serum_bileacids kegg 0.319 NA no no no no no no GLCA+stool ACA+stool 0 0 0.549734645 stool_bileacids stool_bileacids 0.617 0.417 no no no no no no GLCA+stool CDCA+stool 0.537137624 0 0 stool_bileacids stool_bileacids 0.617 0.663 no no no no no no GLCA+stool DCA+stool -0.644354918 0 0 stool_bileacids stool_bileacids 0.617 0.195 no no no no no no Glioma 2-Oxocarboxylic acid metabolism -0.599130435 0 0 kegg kegg NA NA no no no no no no Glioma ABC transporters -0.456521739 0 0 kegg kegg NA NA no no no no up up Glioma Adipocytokine signaling pathway 0 0 -0.429086229 kegg kegg NA NA no no no no no no Glioma Adrenergic signaling in cardiomyocytes 0.570434783 0 0 kegg kegg NA NA no no no no no up Glioma AGE-RAGE signaling pathway in diabetic complications 0.455652174 0 0.494980695 kegg kegg NA NA no no no no no no Glioma Aldosterone synthesis and secretion 0.42173913 0 0 kegg kegg NA NA no no no no up up Glioma Aldosterone-regulated sodium reabsorption 0.756521739 0.598814229 0.558815959 kegg kegg NA NA no no no no no no Glioma alpha-Linolenic acid metabolism -0.653913043 0 0 kegg kegg NA NA no no no no no no Glioma Alzheimer disease 0.482608696 0 0 kegg kegg NA NA no no no no no no Glioma Amino sugar and nucleotide sugar metabolism -0.69826087 0 0 kegg kegg NA NA no no no no no no Glioma Aminoacyl-tRNA biosynthesis -0.44173913 0 0 kegg kegg NA NA no no no no no no Glioma Antifolate resistance -0.414782609 0 0 kegg kegg NA NA no no no no no no Glioma Arachidonic acid metabolism -0.476521739 -0.522727273 -0.578635779 kegg kegg NA NA no no no no no no Glioma Arginine biosynthesis 0 0 -0.404890605 kegg kegg NA NA no no no no no no Glioma Autophagy - animal 0.468695652 0.443675889 0.475160875 kegg kegg NA NA no no no no no no Glioma Autophagy - other 0.479130435 0 0.672586873 kegg kegg NA NA no no no no no no Glioma Axon guidance 0.697391304 0.493083004 0.48030888 kegg kegg NA NA no no no no up up Glioma Bacterial invasion of epithelial cells -0.500869565 0 0 kegg kegg NA NA no no no no no no Glioma Basal transcription factors 0 0 0.590990991 kegg kegg NA NA no no no no no no Glioma beta-Alanine metabolism -0.68 0 0 kegg kegg NA NA no no no no no no Glioma Bile secretion 0 -0.431818182 -0.403088803 kegg kegg NA NA no no no no no no Glioma Biosynthesis of amino acids -0.563478261 0 -0.537709138 kegg kegg NA NA no no no no no no Glioma Biosynthesis of cofactors -0.63826087 0 -0.437837838 kegg kegg NA NA no no no no no no Glioma Butanoate metabolism -0.631304348 0 0 kegg kegg NA NA no no no no no no Glioma C-type lectin receptor signaling pathway 0.5 0 0 kegg kegg NA NA no no no no no no Glioma Calcium signaling pathway 0.71826087 0 0 kegg kegg NA NA no no no no up up Glioma cAMP signaling pathway 0.626956522 0 0 yes kegg kegg NA NA no no no no up up Glioma Carbohydrate digestion and absorption 0.477391304 0.463438735 0.571171171 kegg kegg NA NA no no no no no no Glioma Carbon metabolism -0.652173913 0 0 kegg kegg NA NA no no no no no no Glioma Cardiac muscle contraction 0.464347826 0 0 kegg kegg NA NA no no no no no up Glioma Cell cycle 0 0 0.707335907 kegg kegg NA NA no no no no no no Glioma cGMP-PKG signaling pathway 0.560869565 0 0 kegg kegg NA NA no no no no no no Glioma Chemical carcinogenesis - DNA adducts -0.476521739 0 0 kegg kegg NA NA no no no no no no Glioma Cholinergic synapse 0.55826087 0 0.586100386 kegg kegg NA NA no no no no no no Glioma Circadian rhythm 0.686956522 0 0.683655084 kegg kegg NA NA no no no no no no Glioma Collecting duct acid secretion 0 0 -0.466666667 kegg kegg NA NA no no no no no no Glioma Collinsella 0 0 -0.463494268 kegg Genus NA 0.128 no no no no no no Glioma Colorectal cancer 0.708695652 0 0.744401544 kegg kegg NA NA no no no no no no Glioma Complement and coagulation cascades -0.47826087 0 -0.456885457 kegg kegg NA NA no no no no no no Glioma Drug metabolism - cytochrome P450 0 -0.47826087 0 kegg kegg NA NA no no no no no no Glioma Drug metabolism - other enzymes -0.57826087 0 0 kegg kegg NA NA no no no no no no Glioma Endocrine and other factor-regulated calcium reabsorption 0 -0.447628458 0 kegg kegg NA NA no no no no no no Glioma Endometrial cancer 0.654782609 0.477272727 0.630630631 kegg kegg NA NA no no no no no no Glioma ErbB signaling pathway 0.690434783 0.460474308 0.728700129 kegg kegg NA NA no no no no no no Glioma Ether lipid metabolism 0 0 0.415444015 kegg kegg NA NA no no no no no no Glioma Fanconi anemia pathway 0 0 0.555727156 kegg kegg NA NA no no no no no no Glioma Fatty acid elongation -0.434782609 0 0 kegg kegg NA NA no no no no no no Glioma Fc epsilon RI signaling pathway 0.577391304 0.516798419 0 kegg kegg NA NA no no no no no no Glioma Fc gamma R-mediated phagocytosis 0 0.528656126 0 kegg kegg NA NA no no no no no no Glioma Ferroptosis 0 0 -0.563449163 kegg kegg NA NA no no no no no no Glioma FoxO signaling pathway 0 0 0.414414414 kegg kegg NA NA no no no no no no Glioma Fructose and mannose metabolism -0.80173913 0 0 kegg kegg NA NA no no no no no no Glioma Galactose metabolism -0.662608696 0 0 kegg kegg NA NA no no no no no no Glioma Gastric acid secretion 0 -0.423913043 0 kegg kegg NA NA no no no no no no Glioma Glutathione metabolism 0 -0.448616601 -0.562419562 kegg kegg NA NA no no no no no no Glioma Glycerolipid metabolism 0 0 0.427541828 kegg kegg NA NA no no no no no up Glioma Glycerophospholipid metabolism 0 0 0.60952381 kegg kegg NA NA no no no no no up Glioma "Glycine, serine and threonine metabolism" -0.472173913 0 -0.433976834 kegg kegg NA NA no no no no up no Glioma Glycolysis / Gluconeogenesis -0.68 0 0 kegg kegg NA NA no no no no no no Glioma Glycosaminoglycan biosynthesis - keratan sulfate 0.449565217 0 0.409009009 kegg kegg NA NA no no no no no no Glioma Glycosphingolipid biosynthesis - lacto and neolacto series 0.490434783 0 0 kegg kegg NA NA no no no no no no Glioma Glyoxylate and dicarboxylate metabolism 0 0 -0.43011583 kegg kegg NA NA no no no no no no Glioma GnRH secretion 0.742608696 0 0.716602317 kegg kegg NA NA no no no no up up Glioma GnRH signaling pathway 0.435652174 0 0 kegg kegg NA NA no no no no no no Glioma "Growth hormone synthesis, secretion and action" 0.482608696 0 0 kegg kegg NA NA no no no no no no Glioma Hedgehog signaling pathway 0.626086957 0 0.645817246 kegg kegg NA NA no no no no no no Glioma Hepatitis B 0.433913043 0 0 kegg kegg NA NA no no no no no no Glioma Hepatitis C 0.453043478 0 0 kegg kegg NA NA no no no no no no Glioma Histidine metabolism -0.472173913 0 0 kegg kegg NA NA no no no no no no Glioma Homologous recombination 0 0 0.516344916 kegg kegg NA NA no no no no no no Glioma Huntington disease 0.44173913 0 0 kegg kegg NA NA no no no no no no Glioma Inflammatory mediator regulation of TRP channels 0.526956522 0 0 kegg kegg NA NA no no no no no no Glioma Inositol phosphate metabolism 0 0 0.546203346 kegg kegg NA NA no no no no no no Glioma Insulin resistance 0.453043478 0 0.411325611 kegg kegg NA NA no no no no no no Glioma Kaposi sarcoma-associated herpesvirus infection 0 0 -0.562419562 kegg kegg NA NA no no no no no dn Glioma Leishmaniasis -0.457391304 0 0 kegg kegg NA NA no no no no no no Glioma Linoleic acid metabolism -0.499130435 -0.441699605 0 kegg kegg NA NA no no no no no no Glioma Long-term potentiation 0.764347826 0 0.806949807 kegg kegg NA NA no no no no no up Glioma Lysine degradation 0 0 0.625740026 kegg kegg NA NA no no no no no no Glioma Malaria 0 0 -0.532818533 kegg kegg NA NA no no no no no no Glioma Mannose type O-glycan biosynthesis 0.411304348 0 0.595881596 kegg kegg NA NA no no no no no no Glioma MAPK signaling pathway 0 0 0.621879022 kegg kegg NA NA no no no no no no Glioma MicroRNAs in cancer 0 0 0.78018018 kegg kegg NA NA no no no no no no Glioma Mineral absorption 0 -0.480237154 -0.509137709 kegg kegg NA NA no no no no no no Glioma Mitophagy - animal 0 0 -0.476190476 kegg kegg NA NA no no no no no no Glioma Morphine addiction 0 -0.451581028 0 kegg kegg NA NA no no no no up up Glioma mRNA surveillance pathway 0.54173913 0 0.662805663 kegg kegg NA NA no no no no no no Glioma N-Glycan biosynthesis 0 0 0.465894466 kegg kegg NA NA no no no no no no Glioma Necroptosis 0 0 -0.522265122 kegg kegg NA NA no no no no no no Glioma Neuroactive ligand-receptor interaction 0 0.464426877 0 kegg kegg NA NA no no no up up up Glioma Neurotrophin signaling pathway 0.583478261 0 0 kegg kegg NA NA no no no no no no Glioma Neutrophil extracellular trap formation 0 0 -0.468725869 kegg kegg NA NA no no no no no no Glioma Non-alcoholic fatty liver disease 0.494782609 0 0 kegg kegg NA NA no no no no no no Glioma Non-homologous end-joining -0.526956522 0 0 kegg kegg NA NA no no no no no no Glioma Notch signaling pathway 0.565217391 0 0.5997426 kegg kegg NA NA no no no no no no Glioma Oocyte meiosis 0.494782609 0 0.73976834 kegg kegg NA NA no no no no no no Glioma Osteoclast differentiation 0 0.545454545 0 kegg kegg NA NA no no no no no no Glioma Other glycan degradation -0.41826087 0 0.407207207 kegg kegg NA NA no no no no no no Glioma Other types of O-glycan biosynthesis 0 0 0.701158301 kegg kegg NA NA no no no no no no Glioma Ovarian steroidogenesis 0 -0.469367589 0 kegg kegg NA NA no no no no up up Glioma Oxidative phosphorylation 0.426956522 0 0 kegg kegg NA NA no no no no no no Glioma p53 signaling pathway 0.414782609 0 0.448133848 kegg kegg NA NA no no no no no no Glioma Pancreatic cancer 0.794782609 0.631422925 0.585328185 kegg kegg NA NA no no no no no no Glioma Pancreatic secretion 0 -0.419960474 0 kegg kegg NA NA no no no no no no Glioma Paraprevotella 0 -0.428393477 0 kegg Genus NA 0.118 no no no no no no Glioma Pathogenic Escherichia coli infection -0.411304348 0 -0.488803089 kegg kegg NA NA no no no no no no Glioma Pathways in cancer 0.672173913 0 0 kegg kegg NA NA no no no no no no Glioma Pentose phosphate pathway -0.435652174 0 -0.449163449 kegg kegg NA NA no no no no no no Glioma Peroxisome 0 0 -0.403088803 kegg kegg NA NA no no no no no no Glioma Phagosome 0 0 -0.477477477 kegg kegg NA NA no no no no no no Glioma Phenylalanine metabolism -0.572173913 0 0 kegg kegg NA NA no no no no no no Glioma Phosphatidylinositol signaling system 0.852173913 0 0.829343629 kegg kegg NA NA no no no no no no Glioma Phototransduction 0 0 0.42007722 kegg kegg NA NA no no no no no no Glioma Platinum drug resistance 0 0 0.523809524 kegg kegg NA NA no no no no no no Glioma Porphyrin and chlorophyll metabolism -0.539130435 -0.43083004 -0.498841699 kegg kegg NA NA no no no no no no Glioma PPAR signaling pathway 0 0.423913043 0 kegg kegg NA NA no no no no no no Glioma Progesterone-mediated oocyte maturation 0.469565217 0 0.729472329 kegg kegg NA NA no no no no no no Glioma Prolactin signaling pathway 0.516521739 0 0 kegg kegg NA NA no no no no no no Glioma Protein digestion and absorption 0 0.466403162 0 yes kegg kegg NA NA no no no no up up Glioma Protein export 0.416521739 0 0.509395109 kegg kegg NA NA no no no no no no Glioma Protein processing in endoplasmic reticulum 0 -0.43083004 0 kegg kegg NA NA no no no no no no Glioma Proximal tubule bicarbonate reclamation 0 0 0.526898327 kegg kegg NA NA no no no no no no Glioma Purine metabolism 0 0 -0.486486486 kegg kegg NA NA no no no no no no Glioma Pyrimidine metabolism -0.512173913 0 0 kegg kegg NA NA no no no no no no Glioma Ras signaling pathway 0.645217391 0 0.70990991 yes kegg kegg NA NA no no no no up up Glioma Renal cell carcinoma 0.666956522 0.438735178 0.41003861 kegg kegg NA NA no no no no no no Glioma Renin-angiotensin system 0 0.484189723 0 kegg kegg NA NA no no no no no no Glioma Ribosome biogenesis in eukaryotes 0 0 0.598970399 kegg kegg NA NA no no no no no no Glioma RNA degradation 0.573913043 0 0.672329472 kegg kegg NA NA no no no no no no Glioma Ruminococcus 0 -0.426945341 0 kegg Genus NA 0.0679 no no no no no dn Glioma Selenocompound metabolism 0 0 0.488030888 kegg kegg NA NA no no no no no no Glioma Serotonergic synapse 0 0 -0.413642214 kegg kegg NA NA no no no no no no Glioma Shigellosis 0 0 -0.563706564 kegg kegg NA NA no no no no no no Glioma Signaling pathways regulating pluripotency of stem cells 0.744347826 0 0.726126126 kegg kegg NA NA no no no no no no Glioma Sphingolipid signaling pathway 0.795652174 0.685770751 0.617760618 kegg kegg NA NA no no no no no no Glioma Spinocerebellar ataxia 0.647826087 0 0.615958816 kegg kegg NA NA no no no no no no Glioma Spliceosome 0 0 0.701158301 kegg kegg NA NA no no no no no no Glioma Staphylococcus aureus infection 0 0 -0.428571429 kegg kegg NA NA no no no up no no Glioma Starch and sucrose metabolism -0.535652174 0 0 kegg kegg NA NA no no no no no no Glioma Steroid hormone biosynthesis -0.446086957 0 0 kegg kegg NA NA no no no no no no Glioma Sulfur metabolism -0.497391304 0 -0.518404118 kegg kegg NA NA no no no no no no Glioma Synthesis and degradation of ketone bodies 0 0 0.433719434 kegg kegg NA NA no no no no no no Glioma T cell receptor signaling pathway 0 0 0.471814672 kegg kegg NA NA no no no no no no Glioma Taste transduction 0 0 0.497812098 kegg kegg NA NA no no no no no up Glioma Terpenoid backbone biosynthesis 0 0 0.528442728 kegg kegg NA NA no no no no no no Glioma TGF-beta signaling pathway 0.614782609 0 0.646846847 kegg kegg NA NA no no no no no no Glioma Thiamine metabolism -0.453913043 0 0 kegg kegg NA NA no no no no no no Glioma Thyroid hormone synthesis 0 -0.490118577 -0.435521236 kegg kegg NA NA no no no no no no Glioma Tight junction -0.493043478 0 0 kegg kegg NA NA no no no no no no Glioma Transcriptional misregulation in cancer 0.417391304 0.416007905 0.436550837 kegg kegg NA NA no no no no no no Glioma Tryptophan metabolism -0.533913043 0 0 kegg kegg NA NA no no no no up no Glioma Type II diabetes mellitus 0.543478261 0.479249012 0.445302445 kegg kegg NA NA no no no no no no Glioma Tyrosine metabolism -0.455652174 0 0 kegg kegg NA NA no no no no no no Glioma Ubiquinone and other terpenoid-quinone biosynthesis -0.453043478 0 0 kegg kegg NA NA no no no no no no Glioma Ubiquitin mediated proteolysis 0 -0.464426877 -0.468983269 kegg kegg NA NA no no no no no no Glioma "Valine, leucine and isoleucine degradation" -0.440869565 0 0 kegg kegg NA NA no no no no no no Glioma Various types of N-glycan biosynthesis 0 0 0.494208494 kegg kegg NA NA no no no no no no Glioma Vasopressin-regulated water reabsorption 0 -0.476284585 0 kegg kegg NA NA no no no no no no Glioma VEGF signaling pathway 0.797391304 0.424901186 0.761904762 kegg kegg NA NA no no no no no no Glioma Vibrio cholerae infection 0 -0.451581028 0 kegg kegg NA NA no no no no no no Glioma Viral protein interaction with cytokine and cytokine receptor 0 0 -0.432432432 kegg kegg NA NA no no no no no no Glioma Vitamin digestion and absorption 0.540869565 0 0 kegg kegg NA NA no no no no no no Glioma Wnt signaling pathway 0.510434783 0 0.728700129 kegg kegg NA NA no no no no no no GLP-1 Ghrelin 0 0.408695652 0 yes DM-assocaited hormones DM-assocaited hormones 0.256 0.0108 no no no dn no no GLP-1 GIP -0.511857708 0 0 DM-assocaited hormones DM-assocaited hormones 0.256 0.374 no no no no no no Glucagon Ghrelin 0.425889328 0.509565217 0.540336134 yes DM-assocaited hormones DM-assocaited hormones 0.0283 0.0108 no no up dn no no Glucagon GLP-1 0.657114625 0.664347826 0.770028011 DM-assocaited hormones DM-assocaited hormones 0.0283 0.256 no no up no no no Glucagon signaling pathway Adrenergic signaling in cardiomyocytes 0.697391304 0.799407115 0.872844273 kegg kegg NA NA no no no no no up Glucagon signaling pathway "Alanine, aspartate and glutamate metabolism" -0.537391304 -0.701581028 -0.501673102 kegg kegg NA NA no no no no no no Glucagon signaling pathway alpha-Linolenic acid metabolism -0.606086957 -0.551383399 -0.477220077 kegg kegg NA NA no no no no no no Glucagon signaling pathway Amino sugar and nucleotide sugar metabolism 0 0 -0.402059202 kegg kegg NA NA no no no no no no Glucagon signaling pathway AMPK signaling pathway 0 0.631422925 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Antifolate resistance 0 0.455533597 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Apelin signaling pathway 0.503478261 0.656126482 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Apoptosis -0.717391304 -0.780632411 -0.711711712 kegg kegg NA NA no no no no no no Glucagon signaling pathway Arginine and proline metabolism -0.60173913 -0.808300395 -0.537194337 kegg kegg NA NA no no no no up no Glucagon signaling pathway Arginine biosynthesis -0.579130435 -0.697628458 -0.551866152 kegg kegg NA NA no no no no no no Glucagon signaling pathway Autophagy - animal 0 -0.589920949 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Autophagy - other 0 0 0.506821107 kegg kegg NA NA no no no no no no Glucagon signaling pathway B cell receptor signaling pathway -0.526956522 -0.777667984 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Basal transcription factors 0 0.633399209 0.52020592 kegg kegg NA NA no no no no no no Glucagon signaling pathway Base excision repair 0 0.47826087 0.42985843 kegg kegg NA NA no no no no no no Glucagon signaling pathway Biosynthesis of amino acids -0.566956522 -0.839920949 -0.727155727 kegg kegg NA NA no no no no no no Glucagon signaling pathway Biosynthesis of cofactors 0 0.661067194 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Butanoate metabolism 0 0.447628458 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway C-type lectin receptor signaling pathway 0 -0.763833992 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Calcium signaling pathway 0.607826087 0.630434783 0.777091377 kegg kegg NA NA no no no no up up Glucagon signaling pathway Carbon metabolism -0.412173913 -0.433794466 -0.685971686 kegg kegg NA NA no no no no no no Glucagon signaling pathway Cardiac muscle contraction 0.425217391 0.740118577 0 kegg kegg NA NA no no no no no up Glucagon signaling pathway Cell adhesion molecules 0 -0.741106719 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Cell cycle 0.536521739 0.734189723 0.657657658 kegg kegg NA NA no no no no no no Glucagon signaling pathway Cellular senescence 0 -0.672924901 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway cGMP-PKG signaling pathway 0 -0.834980237 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Chemokine signaling pathway 0 -0.669960474 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Circadian entrainment 0.680869565 0.606719368 0.418275418 kegg kegg NA NA no no no no up up Glucagon signaling pathway Circadian rhythm 0.451304348 0.649209486 0.640926641 kegg kegg NA NA no no no no no no Glucagon signaling pathway Citrate cycle (TCA cycle) 0 0.420948617 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Complement and coagulation cascades -0.482608696 -0.812252964 -0.593822394 kegg kegg NA NA no no no no no no Glucagon signaling pathway Cysteine and methionine metabolism 0 0.504940711 0.516344916 kegg kegg NA NA no no no no no no Glucagon signaling pathway DNA replication 0 0.644268775 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Dopaminergic synapse 0.684347826 0.701581028 0.737709138 kegg kegg NA NA no no no no up no Glucagon signaling pathway Drug metabolism - cytochrome P450 0 0.554347826 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Drug metabolism - other enzymes 0 0.458498024 -0.500643501 kegg kegg NA NA no no no no no no Glucagon signaling pathway ECM-receptor interaction 0.431304348 0 0.47953668 kegg kegg NA NA no no no no up up Glucagon signaling pathway EGFR tyrosine kinase inhibitor resistance 0 0.583003953 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Endocrine resistance 0.66 0.574110672 0.476705277 kegg kegg NA NA no no no no no no Glucagon signaling pathway Endocytosis 0 -0.739130435 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Estrogen signaling pathway 0.586086957 0.648221344 0.433204633 kegg kegg NA NA no no no no no no Glucagon signaling pathway Ether lipid metabolism 0 0.624505929 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Fanconi anemia pathway 0 0.473320158 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Fatty acid biosynthesis -0.454782609 -0.734189723 -0.421106821 kegg kegg NA NA no no no no no no Glucagon signaling pathway Fatty acid degradation -0.433913043 -0.614624506 -0.495495495 kegg kegg NA NA no no no no no no Glucagon signaling pathway Fatty acid metabolism -0.509565217 -0.645256917 -0.473101673 kegg kegg NA NA no no no no no no Glucagon signaling pathway Fc epsilon RI signaling pathway 0 -0.802371542 -0.531788932 kegg kegg NA NA no no no no no no Glucagon signaling pathway Fc gamma R-mediated phagocytosis -0.564347826 -0.845849802 -0.604375804 kegg kegg NA NA no no no no no no Glucagon signaling pathway Folate biosynthesis 0 0.416996047 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Fructose and mannose metabolism -0.5 0 -0.677477477 kegg kegg NA NA no no no no no no Glucagon signaling pathway GABAergic synapse 0 -0.544466403 0 kegg kegg NA NA no no no no up up Glucagon signaling pathway Galactose metabolism -0.624347826 -0.586956522 -0.496782497 kegg kegg NA NA no no no no no no Glucagon signaling pathway Gap junction 0.550434783 0 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Glutamatergic synapse 0.415652174 0 0 kegg kegg NA NA no no no no up up Glucagon signaling pathway Glutathione metabolism 0 0.68083004 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Glycerolipid metabolism -0.466956522 0 0 kegg kegg NA NA no no no no no up Glucagon signaling pathway "Glycine, serine and threonine metabolism" 0 0.595849802 0 kegg kegg NA NA no no no no up no Glucagon signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.54173913 -0.568181818 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Glycosaminoglycan degradation -0.530434783 -0.66798419 0 kegg kegg NA NA no no no no no up Glucagon signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.472332016 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Glyoxylate and dicarboxylate metabolism -0.668695652 -0.730237154 -0.606177606 kegg kegg NA NA no no no no no no Glucagon signaling pathway GnRH signaling pathway 0.744347826 0.747035573 0.73024453 kegg kegg NA NA no no no no no no Glucagon signaling pathway Hedgehog signaling pathway 0.446086957 0.504940711 0.428571429 kegg kegg NA NA no no no no no no Glucagon signaling pathway HIF-1 signaling pathway 0 0.445652174 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Hippo signaling pathway 0 0.448616601 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Hippo signaling pathway - multiple species -0.539130435 -0.646245059 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Histidine metabolism -0.406956522 0 -0.523809524 kegg kegg NA NA no no no no no no Glucagon signaling pathway Homologous recombination 0 0 0.430630631 kegg kegg NA NA no no no no no no Glucagon signaling pathway IL-17 signaling pathway -0.565217391 -0.806324111 -0.631660232 kegg kegg NA NA no no no no no no Glucagon signaling pathway Inflammatory mediator regulation of TRP channels 0.811304348 0.889328063 0.823680824 kegg kegg NA NA no no no no no no Glucagon signaling pathway Insulin secretion 0.614782609 0.745059289 0.653539254 yes kegg kegg NA NA no no no no up up Glucagon signaling pathway Insulin signaling pathway 0.42173913 0.605731225 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway JAK-STAT signaling pathway 0 -0.435770751 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Leukocyte transendothelial migration 0 0 -0.407464607 kegg kegg NA NA no no no no no no Glucagon signaling pathway Long-term depression 0.526956522 0 0.404375804 kegg kegg NA NA no no no no no no Glucagon signaling pathway Long-term potentiation 0.616521739 0 0.542084942 kegg kegg NA NA no no no no no up Glucagon signaling pathway Lysine degradation 0 0 0.428314028 kegg kegg NA NA no no no no no no Glucagon signaling pathway Lysosome -0.64 -0.789525692 -0.777606178 kegg kegg NA NA no no no no no no Glucagon signaling pathway Mannose type O-glycan biosynthesis 0 0 0.437323037 kegg kegg NA NA no no no no no no Glucagon signaling pathway Melanogenesis 0.773043478 0.907114625 0.843500644 kegg kegg NA NA no no no no no no Glucagon signaling pathway Metabolism of xenobiotics by cytochrome P450 0 0.461462451 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Mismatch repair 0 0.530632411 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Mitophagy - animal 0.486086957 0.700592885 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway mRNA surveillance pathway 0.426086957 0.751976285 0.736936937 kegg kegg NA NA no no no no no no Glucagon signaling pathway mTOR signaling pathway 0 0.56027668 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway N-Glycan biosynthesis 0.555652174 0.70256917 0.497039897 kegg kegg NA NA no no no no no no Glucagon signaling pathway Natural killer cell mediated cytotoxicity -0.412173913 -0.683794466 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Necroptosis 0.495652174 0 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Neuroactive ligand-receptor interaction -0.411304348 -0.804347826 -0.657142857 kegg kegg NA NA no no no up up up Glucagon signaling pathway Neurotrophin signaling pathway 0 -0.583003953 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Neutrophil extracellular trap formation -0.685217391 -0.791501976 -0.698584299 kegg kegg NA NA no no no no no no Glucagon signaling pathway NF-kappa B signaling pathway -0.54 -0.659090909 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Nicotinate and nicotinamide metabolism -0.565217391 -0.751976285 -0.594851995 kegg kegg NA NA no no no no no no Glucagon signaling pathway Nitrogen metabolism -0.514782609 -0.62055336 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway NOD-like receptor signaling pathway -0.614782609 -0.787549407 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Nucleotide excision repair 0 0.645256917 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Olfactory transduction 0 -0.707509881 -0.623423423 kegg kegg NA NA no no no no no no Glucagon signaling pathway One carbon pool by folate 0 0.670948617 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Oocyte meiosis 0.533043478 0 0.614671815 kegg kegg NA NA no no no no no no Glucagon signaling pathway Osteoclast differentiation -0.78173913 -0.881422925 -0.602316602 kegg kegg NA NA no no no no no no Glucagon signaling pathway Other glycan degradation -0.574782609 0 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Other types of O-glycan biosynthesis 0 0.427865613 0.445045045 kegg kegg NA NA no no no no no no Glucagon signaling pathway Ovarian steroidogenesis 0.594782609 0.558300395 0 kegg kegg NA NA no no no no up up Glucagon signaling pathway Oxidative phosphorylation 0.406956522 0.738142292 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Pantothenate and CoA biosynthesis -0.454782609 -0.760869565 -0.634749035 kegg kegg NA NA no no no no no dn Glucagon signaling pathway Parabacteroides 0 0 -0.411995625 kegg Genus NA 4.19E-05 no no no no up up Glucagon signaling pathway Pentose and glucuronate interconversions 0 0.575098814 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Pentose phosphate pathway -0.695652174 -0.851778656 -0.779407979 kegg kegg NA NA no no no no no no Glucagon signaling pathway Peroxisome -0.490434783 -0.736166008 -0.448391248 kegg kegg NA NA no no no no no no Glucagon signaling pathway Phagosome -0.500869565 -0.774703557 -0.581209781 kegg kegg NA NA no no no no no no Glucagon signaling pathway Phosphatidylinositol signaling system 0.505217391 0.419960474 0.489060489 kegg kegg NA NA no no no no no no Glucagon signaling pathway Phospholipase D signaling pathway 0 -0.436758893 0 kegg kegg NA NA no no no no up up Glucagon signaling pathway Phototransduction 0.510434783 0 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway PI3K-Akt signaling pathway 0 0 0.432175032 yes kegg kegg NA NA no no no no up up Glucagon signaling pathway Porphyrin and chlorophyll metabolism 0 0.522727273 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway PPAR signaling pathway -0.425217391 -0.816205534 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Prolactin signaling pathway 0 -0.643280632 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Propanoate metabolism 0 0.444664032 0.413899614 kegg kegg NA NA no no no no no no Glucagon signaling pathway Protein export 0.57826087 0.597826087 0.572200772 kegg kegg NA NA no no no no no no Glucagon signaling pathway Protein processing in endoplasmic reticulum 0.669565217 0.732213439 0.404118404 kegg kegg NA NA no no no no no no Glucagon signaling pathway Purine metabolism 0 0.628458498 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Pyramidobacter 0 0 0.403624964 kegg Genus NA 0.45 no no no no no no Glucagon signaling pathway Pyrimidine metabolism 0 0.572134387 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Pyruvate metabolism 0 0.602766798 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Ras signaling pathway 0 0.508893281 0.438610039 yes kegg kegg NA NA no no no no up up Glucagon signaling pathway Renin-angiotensin system 0 -0.825098814 -0.543114543 kegg kegg NA NA no no no no no no Glucagon signaling pathway Retrograde endocannabinoid signaling 0 0.679841897 0 kegg kegg NA NA no no no no no up Glucagon signaling pathway Ribosome 0.536521739 0.685770751 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Ribosome biogenesis in eukaryotes 0.470434783 0.70256917 0.541827542 kegg kegg NA NA no no no no no no Glucagon signaling pathway RIG-I-like receptor signaling pathway 0 -0.664031621 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway RNA degradation 0.411304348 0.751976285 0.580694981 kegg kegg NA NA no no no no no no Glucagon signaling pathway RNA polymerase 0.48173913 0.824110672 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway RNA transport 0 0.449604743 0.524581725 kegg kegg NA NA no no no no no no Glucagon signaling pathway Sarcina 0 -0.444554224 0 kegg Genus NA 0.0703 no no no no no no Glucagon signaling pathway Serotonergic synapse 0.41826087 0 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Signaling pathways regulating pluripotency of stem cells 0 0 0.461776062 kegg kegg NA NA no no no no no no Glucagon signaling pathway SNARE interactions in vesicular transport 0 -0.502964427 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Sphingolipid metabolism -0.533043478 0 -0.516344916 kegg kegg NA NA no no no no no no Glucagon signaling pathway Sphingolipid signaling pathway 0 -0.625494071 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Spliceosome 0 0 0.687773488 kegg kegg NA NA no no no no no no Glucagon signaling pathway Starch and sucrose metabolism -0.671304348 -0.71541502 -0.766023166 kegg kegg NA NA no no no no no no Glucagon signaling pathway Steroid biosynthesis 0.616521739 0.437747036 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Synaptic vesicle cycle -0.453913043 -0.76284585 -0.79047619 kegg kegg NA NA no no no no up up Glucagon signaling pathway Synthesis and degradation of ketone bodies 0 0.507905138 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway T cell receptor signaling pathway 0 0 0.451737452 kegg kegg NA NA no no no no no no Glucagon signaling pathway Taste transduction 0.426086957 0.648221344 0 kegg kegg NA NA no no no no no up Glucagon signaling pathway TGF-beta signaling pathway 0 0.541501976 0.401544402 kegg kegg NA NA no no no no no no Glucagon signaling pathway Th1 and Th2 cell differentiation -0.451304348 -0.489130435 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Th17 cell differentiation -0.426086957 -0.5 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Thermogenesis 0.474782609 0.785573123 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Thiamine metabolism 0 0.442687747 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Thyroid hormone signaling pathway 0 0.442687747 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Thyroid hormone synthesis 0.669565217 0.677865613 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Tight junction 0 0 -0.442213642 kegg kegg NA NA no no no no no no Glucagon signaling pathway TNF signaling pathway 0 -0.615612648 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Toll-like receptor signaling pathway 0 -0.803359684 0 yes kegg kegg NA NA no no no no no no Glucagon signaling pathway Tyrosine metabolism 0 0.540513834 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Ubiquitin mediated proteolysis 0.54 0.799407115 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway "Valine, leucine and isoleucine degradation" 0 0.449604743 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Various types of N-glycan biosynthesis 0.5 0.497035573 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Vascular smooth muscle contraction 0.631304348 0.67687747 0.442985843 kegg kegg NA NA no no no no no no Glucagon signaling pathway VEGF signaling pathway 0 -0.482213439 0 kegg kegg NA NA no no no no no no Glucagon signaling pathway Wnt signaling pathway 0 0.751976285 0.509137709 kegg kegg NA NA no no no no no no Glutamatergic synapse 2-Oxocarboxylic acid metabolism 0 -0.598814229 -0.738996139 kegg kegg NA NA no up up no no no Glutamatergic synapse ABC transporters -0.719130435 0 -0.44041184 kegg kegg NA NA no up up no up up Glutamatergic synapse Adrenergic signaling in cardiomyocytes 0.516521739 0 0 kegg kegg NA NA no up up no no up Glutamatergic synapse "Alanine, aspartate and glutamate metabolism" 0 0.42687747 0.41956242 kegg kegg NA NA no up up no no no Glutamatergic synapse alpha-Linolenic acid metabolism -0.479130435 0 -0.44993565 kegg kegg NA NA no up up no no no Glutamatergic synapse Amino sugar and nucleotide sugar metabolism 0 0 -0.400514801 kegg kegg NA NA no up up no no no Glutamatergic synapse Aminoacyl-tRNA biosynthesis -0.522608696 -0.455533597 0 kegg kegg NA NA no up up no no no Glutamatergic synapse AMPK signaling pathway 0 0 0.505791506 kegg kegg NA NA no up up no no no Glutamatergic synapse Antifolate resistance -0.410434783 0 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Apelin signaling pathway 0 -0.425889328 -0.427799228 kegg kegg NA NA no up up no no no Glutamatergic synapse Arachidonic acid metabolism 0 0 0.406949807 kegg kegg NA NA no up up no no no Glutamatergic synapse Arginine biosynthesis 0 0.458498024 0.489060489 kegg kegg NA NA no up up no no no Glutamatergic synapse Ascorbate and aldarate metabolism 0 -0.431818182 -0.73024453 kegg kegg NA NA no up up no no no Glutamatergic synapse Basal transcription factors 0 0 -0.405148005 kegg kegg NA NA no up up no no no Glutamatergic synapse Base excision repair -0.413043478 0 0 kegg kegg NA NA no up up no no no Glutamatergic synapse beta-Alanine metabolism 0 -0.517786561 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Bifidobacterium 0 -0.450719559 0 acetate-producing kegg Genus NA 0.105 no up up no dn no Glutamatergic synapse Biosynthesis of cofactors 0 0 0.509137709 kegg kegg NA NA no up up no no no Glutamatergic synapse Butanoate metabolism -0.43826087 -0.595849802 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Calcium signaling pathway 0.473043478 0 0 kegg kegg NA NA no up up no up up Glutamatergic synapse cAMP signaling pathway 0 0.469367589 0.489317889 yes kegg kegg NA NA no up up no up up Glutamatergic synapse Carbon metabolism 0 -0.57312253 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Circadian entrainment 0.660869565 0 0.674131274 kegg kegg NA NA no up up no up up Glutamatergic synapse Circadian rhythm 0 0 -0.403346203 kegg kegg NA NA no up up no no no Glutamatergic synapse Citrate cycle (TCA cycle) -0.433043478 -0.654150198 -0.692406692 kegg kegg NA NA no up up no no no Glutamatergic synapse Clostridium 0 -0.511440348 0 kegg Genus NA 0.925 no up up no no no Glutamatergic synapse Cysteine and methionine metabolism 0 -0.639328063 0 kegg kegg NA NA no up up no no no Glutamatergic synapse DNA replication -0.486086957 -0.42687747 -0.513513514 kegg kegg NA NA no up up no no no Glutamatergic synapse Drug metabolism - cytochrome P450 0 -0.490118577 -0.428571429 kegg kegg NA NA no up up no no no Glutamatergic synapse Drug metabolism - other enzymes 0 -0.593873518 -0.532303732 kegg kegg NA NA no up up no no no Glutamatergic synapse EGFR tyrosine kinase inhibitor resistance 0 -0.46541502 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Endocrine resistance 0.549565217 0.488142292 0.63963964 kegg kegg NA NA no up up no no no Glutamatergic synapse Ether lipid metabolism 0 0 -0.520720721 kegg kegg NA NA no up up no no no Glutamatergic synapse Fanconi anemia pathway -0.460869565 0 -0.467696268 kegg kegg NA NA no up up no no no Glutamatergic synapse Fatty acid elongation 0 -0.470355731 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Ferroptosis 0.588695652 0.470355731 0.487258687 kegg kegg NA NA no up up no no no Glutamatergic synapse Folate biosynthesis -0.55826087 -0.511857708 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Fructose and mannose metabolism 0 0 -0.421621622 kegg kegg NA NA no up up no no no Glutamatergic synapse Galactose metabolism 0 0 -0.651994852 kegg kegg NA NA no up up no no no Glutamatergic synapse Gap junction 0.745217391 0.809288538 0.801029601 kegg kegg NA NA no up up no no no Glutamatergic synapse Glutathione metabolism 0 0 0.478507079 kegg kegg NA NA no up up no no no Glutamatergic synapse Glycerolipid metabolism -0.508695652 0 -0.727155727 kegg kegg NA NA no up up no no up Glutamatergic synapse Glycerophospholipid metabolism 0 0 -0.631660232 kegg kegg NA NA no up up no no up Glutamatergic synapse "Glycine, serine and threonine metabolism" 0 0 0.549292149 kegg kegg NA NA no up up no up no Glutamatergic synapse Glycolysis / Gluconeogenesis 0 -0.741106719 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.542490119 -0.474903475 kegg kegg NA NA no up up no no no Glutamatergic synapse Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.815444015 kegg kegg NA NA no up up no no no Glutamatergic synapse Glycosaminoglycan degradation 0 0 -0.712483912 kegg kegg NA NA no up up no no up Glutamatergic synapse Hedgehog signaling pathway 0 0 -0.517117117 kegg kegg NA NA no up up no no no Glutamatergic synapse Hematopoietic cell lineage 0 -0.744071146 0 kegg kegg NA NA no up up no no no Glutamatergic synapse HIF-1 signaling pathway 0 -0.583003953 -0.412097812 kegg kegg NA NA no up up no no no Glutamatergic synapse Hippo signaling pathway 0 -0.423913043 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Hippo signaling pathway - multiple species -0.416521739 0 -0.470527671 kegg kegg NA NA no up up no no no Glutamatergic synapse Histidine metabolism 0 0 -0.406692407 kegg kegg NA NA no up up no no no Glutamatergic synapse Inositol phosphate metabolism -0.49826087 0 -0.56988417 kegg kegg NA NA no up up no no no Glutamatergic synapse Intestinal immune network for IgA production 0 -0.610671937 0 kegg kegg NA NA no up up no no no Glutamatergic synapse JAK-STAT signaling pathway 0 0.416996047 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Long-term potentiation 0 -0.515810277 0 kegg kegg NA NA no up up no no up Glutamatergic synapse Longevity regulating pathway 0.405217391 0.528656126 0.472586873 kegg kegg NA NA no up up no no no Glutamatergic synapse Lysine degradation -0.563478261 0 -0.635778636 kegg kegg NA NA no up up no no no Glutamatergic synapse Mannose type O-glycan biosynthesis 0 0 -0.594851995 kegg kegg NA NA no up up no no no Glutamatergic synapse MAPK signaling pathway 0 0 -0.466409266 kegg kegg NA NA no up up no no no Glutamatergic synapse Metabolism of xenobiotics by cytochrome P450 0 -0.537549407 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Mismatch repair -0.425217391 0 0 kegg kegg NA NA no up up no no no Glutamatergic synapse mRNA surveillance pathway 0 0 -0.4002574 kegg kegg NA NA no up up no no no Glutamatergic synapse mTOR signaling pathway 0 -0.48715415 0 kegg kegg NA NA no up up no no no Glutamatergic synapse N-Glycan biosynthesis 0 -0.425889328 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Necroptosis 0.522608696 0 0.489060489 kegg kegg NA NA no up up no no no Glutamatergic synapse NF-kappa B signaling pathway -0.534782609 0 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Nicotinate and nicotinamide metabolism 0 0.473320158 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Nitrogen metabolism 0 0.551383399 0.625740026 kegg kegg NA NA no up up no no no Glutamatergic synapse Non-homologous end-joining 0 -0.561264822 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Notch signaling pathway 0 0.457509881 -0.604375804 kegg kegg NA NA no up up no no no Glutamatergic synapse Nucleotide excision repair -0.465217391 0 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Odoribacter 0 -0.480437333 0 butyrate-producing kegg Genus NA 0.798 no up up no no no Glutamatergic synapse One carbon pool by folate 0 0 -0.577091377 kegg kegg NA NA no up up no no no Glutamatergic synapse Oocyte meiosis 0 -0.585968379 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Other glycan degradation -0.540869565 0 -0.682368082 kegg kegg NA NA no up up no no no Glutamatergic synapse Other types of O-glycan biosynthesis 0 0 -0.488030888 kegg kegg NA NA no up up no no no Glutamatergic synapse Pentose and glucuronate interconversions 0 -0.613636364 -0.615701416 kegg kegg NA NA no up up no no no Glutamatergic synapse Phenylalanine metabolism 0 -0.497035573 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Phosphatidylinositol signaling system 0 0 -0.498326898 kegg kegg NA NA no up up no no no Glutamatergic synapse Phospholipase D signaling pathway 0 0.754940711 0 kegg kegg NA NA no up up no up up Glutamatergic synapse PI3K-Akt signaling pathway -0.511304348 0 0 yes kegg kegg NA NA no up up no up up Glutamatergic synapse Porphyrin and chlorophyll metabolism 0 0 0.525096525 kegg kegg NA NA no up up no no no Glutamatergic synapse Prevotella -0.43788027 0 0 kegg Genus NA 0.367 no up up no no no Glutamatergic synapse Primary bile acid biosynthesis 0 -0.523715415 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Propanoate metabolism 0 -0.639328063 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Proteasome 0 -0.778656126 -0.556241956 kegg kegg NA NA no up up no no no Glutamatergic synapse Protein export 0 -0.577075099 -0.4998713 kegg kegg NA NA no up up no no no Glutamatergic synapse Pyruvate metabolism -0.434782609 -0.591897233 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Retinol metabolism 0 0 -0.531016731 kegg kegg NA NA no up up no no no Glutamatergic synapse Ribosome biogenesis in eukaryotes 0 0 -0.528700129 kegg kegg NA NA no up up no no no Glutamatergic synapse RNA degradation 0 -0.460474308 -0.593050193 kegg kegg NA NA no up up no no no Glutamatergic synapse RNA polymerase 0 0 -0.511969112 kegg kegg NA NA no up up no no no Glutamatergic synapse RNA transport -0.53826087 -0.58201581 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Selenocompound metabolism 0 0 -0.541312741 kegg kegg NA NA no up up no no no Glutamatergic synapse SNARE interactions in vesicular transport -0.66 0 -0.406949807 kegg kegg NA NA no up up no no no Glutamatergic synapse Sphingolipid metabolism 0 0 -0.525096525 kegg kegg NA NA no up up no no no Glutamatergic synapse Steroid hormone biosynthesis 0 0 -0.537451737 kegg kegg NA NA no up up no no no Glutamatergic synapse T cell receptor signaling pathway -0.460869565 0 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Taurine and hypotaurine metabolism 0 0.506916996 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Terpenoid backbone biosynthesis 0 0 -0.497812098 kegg kegg NA NA no up up no no no Glutamatergic synapse TGF-beta signaling pathway 0 -0.507905138 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Th1 and Th2 cell differentiation 0 0 -0.51042471 kegg kegg NA NA no up up no no no Glutamatergic synapse Th17 cell differentiation 0 0 -0.489060489 kegg kegg NA NA no up up no no no Glutamatergic synapse Thiamine metabolism -0.523478261 0 0 kegg kegg NA NA no up up no no no Glutamatergic synapse Tryptophan metabolism -0.411304348 -0.589920949 -0.461776062 kegg kegg NA NA no up up no up no Glutamatergic synapse Ubiquinone and other terpenoid-quinone biosynthesis -0.413043478 0 -0.422393822 kegg kegg NA NA no up up no no no Glutamatergic synapse "Valine, leucine and isoleucine degradation" -0.486086957 -0.477272727 -0.456885457 kegg kegg NA NA no up up no no no Glutamatergic synapse Various types of N-glycan biosynthesis 0 -0.437747036 -0.456885457 kegg kegg NA NA no up up no no no Glutamatergic synapse Vascular smooth muscle contraction 0.446086957 0 0.532303732 kegg kegg NA NA no up up no no no Glutamatergic synapse Wnt signaling pathway 0 0 -0.521235521 kegg kegg NA NA no up up no no no Glutathione metabolism "Alanine, aspartate and glutamate metabolism" 0 -0.536561265 0 kegg kegg NA NA no no no no no no Glutathione metabolism Arginine and proline metabolism 0 -0.537549407 0 kegg kegg NA NA no no no no up no Glutathione metabolism Arginine biosynthesis 0 -0.502964427 0 kegg kegg NA NA no no no no no no Glutathione metabolism Ascorbate and aldarate metabolism 0 0 -0.403346203 kegg kegg NA NA no no no no no no Glutathione metabolism Butyricimonas -0.422451042 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Glutathione metabolism Citrate cycle (TCA cycle) 0 0.447628458 0 kegg kegg NA NA no no no no no no Glutathione metabolism Cysteine and methionine metabolism 0 0.550395257 0 kegg kegg NA NA no no no no no no Glutathione metabolism Fatty acid biosynthesis 0 -0.646245059 0 kegg kegg NA NA no no no no no no Glutathione metabolism Fatty acid degradation 0 -0.614624506 0 kegg kegg NA NA no no no no no no Glutathione metabolism Galactose metabolism 0 -0.735177866 0 kegg kegg NA NA no no no no no no Glutathione metabolism "Glycine, serine and threonine metabolism" 0.609565217 0.615612648 0.787902188 kegg kegg NA NA no no no no up no Glutathione metabolism Glycolysis / Gluconeogenesis 0 0.435770751 0 kegg kegg NA NA no no no no no no Glutathione metabolism Lysine degradation 0 0 -0.507078507 kegg kegg NA NA no no no no no no Glutathione metabolism Oxidative phosphorylation 0 0.673913043 0 kegg kegg NA NA no no no no no no Glutathione metabolism Paraprevotella 0 0 0.478146677 kegg Genus NA 0.118 no no no no no no Glutathione metabolism Pentose and glucuronate interconversions 0 0.450592885 0 kegg kegg NA NA no no no no no no Glutathione metabolism Pentose phosphate pathway 0 -0.545454545 0 kegg kegg NA NA no no no no no no Glutathione metabolism Purine metabolism 0.655652174 0.636363636 0.502960103 kegg kegg NA NA no no no no no no Glutathione metabolism Pyrimidine metabolism 0 0.555335968 0 kegg kegg NA NA no no no no no no Glutathione metabolism Taurine and hypotaurine metabolism 0 0 -0.446589447 kegg kegg NA NA no no no no no no Glutathione metabolism Tyrosine metabolism 0 0.520750988 0 kegg kegg NA NA no no no no no no Glycerolipid metabolism "Alanine, aspartate and glutamate metabolism" 0 0.421936759 0 kegg kegg NA NA no no up no no no Glycerolipid metabolism Amino sugar and nucleotide sugar metabolism 0 0.553359684 0 kegg kegg NA NA no no up no no no Glycerolipid metabolism Arginine biosynthesis 0 0 -0.502445302 kegg kegg NA NA no no up no no no Glycerolipid metabolism Ascorbate and aldarate metabolism 0 0 0.612612613 kegg kegg NA NA no no up no no no Glycerolipid metabolism Citrate cycle (TCA cycle) 0 0 0.412097812 kegg kegg NA NA no no up no no no Glycerolipid metabolism Cysteine and methionine metabolism 0 -0.415019763 0 kegg kegg NA NA no no up no no no Glycerolipid metabolism Fatty acid biosynthesis 0 0.45256917 0 kegg kegg NA NA no no up no no no Glycerolipid metabolism Fatty acid degradation 0 0.524703557 0 kegg kegg NA NA no no up no no no Glycerolipid metabolism Fructose and mannose metabolism 0 0.716403162 0 kegg kegg NA NA no no up no no no Glycerolipid metabolism Galactose metabolism 0.475652174 0.685770751 0.541055341 kegg kegg NA NA no no up no no no Glycerolipid metabolism Glutathione metabolism 0 -0.513833992 -0.543371943 kegg kegg NA NA no no up no no no Glycerolipid metabolism "Glycine, serine and threonine metabolism" 0 0 -0.466151866 kegg kegg NA NA no no up no up no Glycerolipid metabolism Glycolysis / Gluconeogenesis 0 -0.619565217 0 kegg kegg NA NA no no up no no no Glycerolipid metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.703557312 0.556499356 kegg kegg NA NA no no up no no no Glycerolipid metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.728700129 kegg kegg NA NA no no up no no no Glycerolipid metabolism Glycosaminoglycan degradation 0 0 0.637323037 kegg kegg NA NA no no up no no up Glycerolipid metabolism Histidine metabolism 0.426086957 0 0 kegg kegg NA NA no no up no no no Glycerolipid metabolism Lysine degradation 0.43826087 0.604743083 0.804375804 kegg kegg NA NA no no up no no no Glycerolipid metabolism Mannose type O-glycan biosynthesis 0 0.491106719 0.815701416 kegg kegg NA NA no no up no no no Glycerolipid metabolism Mucin type O-glycan biosynthesis 0 0.442687747 0 kegg kegg NA NA no no up no no no Glycerolipid metabolism N-Glycan biosynthesis 0 0 0.477734878 kegg kegg NA NA no no up no no no Glycerolipid metabolism Other glycan degradation 0.543478261 0.789525692 0.807979408 kegg kegg NA NA no no up no no no Glycerolipid metabolism Other types of O-glycan biosynthesis 0 0.644268775 0.754182754 kegg kegg NA NA no no up no no no Glycerolipid metabolism Oxidative phosphorylation 0 -0.632411067 0 kegg kegg NA NA no no up no no no Glycerolipid metabolism Pentose and glucuronate interconversions 0 0 0.480566281 kegg kegg NA NA no no up no no no Glycerolipid metabolism Pyrimidine metabolism 0 0 0.432947233 kegg kegg NA NA no no up no no no Glycerolipid metabolism Selenocompound metabolism 0 0.682806324 0.697554698 kegg kegg NA NA no no up no no no Glycerolipid metabolism Starch and sucrose metabolism 0 0.536561265 0 kegg kegg NA NA no no up no no no Glycerolipid metabolism Steroid hormone biosynthesis 0 0 0.483655084 kegg kegg NA NA no no up no no no Glycerolipid metabolism Taurine and hypotaurine metabolism 0.503478261 0.811264822 0.637580438 kegg kegg NA NA no no up no no no Glycerolipid metabolism Various types of N-glycan biosynthesis 0 0 0.495752896 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Amino sugar and nucleotide sugar metabolism 0 0.644268775 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Arginine biosynthesis 0 0 -0.47953668 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Ascorbate and aldarate metabolism 0 0 0.632175032 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Citrate cycle (TCA cycle) 0 0 0.444272844 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Fatty acid elongation 0 -0.503952569 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Fructose and mannose metabolism 0 0.623517787 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Glutathione metabolism 0 0 -0.513513514 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Glycerolipid metabolism 0.62173913 0.831027668 0.87953668 kegg kegg NA NA no no up no no up Glycerophospholipid metabolism "Glycine, serine and threonine metabolism" 0 0 -0.437323037 kegg kegg NA NA no no up no up no Glycerophospholipid metabolism Glycolysis / Gluconeogenesis 0 -0.64229249 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.544466403 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.612097812 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Glycosaminoglycan degradation 0 0 0.503217503 kegg kegg NA NA no no up no no up Glycerophospholipid metabolism Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.56 0.709486166 0.41956242 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Inositol phosphate metabolism 0.609565217 0.830039526 0.888803089 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Lysine degradation 0.569565217 0.685770751 0.875160875 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Mannose type O-glycan biosynthesis 0.450434783 0.555335968 0.830888031 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Mucin type O-glycan biosynthesis 0 0.515810277 0 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism N-Glycan biosynthesis 0 0 0.521750322 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Other glycan degradation 0 0.710474308 0.761132561 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Other types of O-glycan biosynthesis 0.7 0.804347826 0.894465894 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Pentose and glucuronate interconversions 0 0 0.42985843 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Pentose phosphate pathway 0 0 -0.456370656 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Pyrimidine metabolism 0 0 0.512998713 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Selenocompound metabolism 0.748695652 0.795454545 0.825482625 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Steroid biosynthesis 0 0 0.433976834 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Steroid hormone biosynthesis 0 0 0.504504505 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Synthesis and degradation of ketone bodies 0 0 0.487516088 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Taurine and hypotaurine metabolism 0.742608696 0.826086957 0.64967825 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0 0 0.440669241 kegg kegg NA NA no no up no no no Glycerophospholipid metabolism Various types of N-glycan biosynthesis 0 0 0.495752896 kegg kegg NA NA no no up no no no "Glycine, serine and threonine metabolism" Ascorbate and aldarate metabolism 0 0 -0.490862291 kegg kegg NA NA no up no no no no "Glycine, serine and threonine metabolism" Citrate cycle (TCA cycle) 0 0 -0.52046332 kegg kegg NA NA no up no no no no "Glycine, serine and threonine metabolism" Collinsella 0.492602449 0 0 kegg Genus NA 0.128 no up no no no no "Glycine, serine and threonine metabolism" Fatty acid biosynthesis -0.470434783 0 0 kegg kegg NA NA no up no no no no "Glycine, serine and threonine metabolism" Galactose metabolism 0 -0.451581028 0 kegg kegg NA NA no up no no no no "Glycine, serine and threonine metabolism" Pentose and glucuronate interconversions 0 0 -0.528442728 kegg kegg NA NA no up no no no no "Glycine, serine and threonine metabolism" Pentose phosphate pathway 0 -0.576086957 0 kegg kegg NA NA no up no no no no "Glycine, serine and threonine metabolism" Purine metabolism 0.639130435 0.908102767 0.563963964 kegg kegg NA NA no up no no no no "Glycine, serine and threonine metabolism" Pyrimidine metabolism 0 0.448616601 0 kegg kegg NA NA no up no no no no "Glycine, serine and threonine metabolism" Synthesis and degradation of ketone bodies 0 0.520750988 0 kegg kegg NA NA no up no no no no Glycine+blood 12-ketoDCA+stool 0 0 -0.523308271 serum_aminoacids stool_bileacids 0.00408 0.505 dn no up no no no Glycine+blood 14:0-LPC+blood 0 0 -0.453675214 serum_aminoacids serum_phospholipids 0.00408 0.00689 dn no up up up no Glycine+blood 14:0/18:2-PC+blood -0.554887218 0 0 serum_aminoacids serum_phospholipids 0.00408 0.102 dn no up no up no Glycine+blood 14:0+blood -0.452631579 0 -0.448888889 yes serum_aminoacids serum_fattyacid 0.00408 0.00572 dn no up up no dn Glycine+blood 14:1/18:2-PG+blood 0 0 -0.556239316 serum_aminoacids serum_phospholipids 0.00408 0.00259 dn no up no up up Glycine+blood 16:0/14:0-PC+blood 0 0 0.461880342 serum_aminoacids serum_phospholipids 0.00408 0.0206 dn no up no up up Glycine+blood 16:0/16:1-PI+blood -0.557894737 0 0 serum_aminoacids serum_phospholipids 0.00408 0.262 dn no up no no no Glycine+blood 16:0/18:1-PC+blood 0.472180451 0 0 serum_aminoacids serum_phospholipids 0.00408 6.15E-07 dn no up up up up Glycine+blood 16:0/18:1-PE+blood 0 0 -0.461880342 serum_aminoacids serum_phospholipids 0.00408 0.000107 dn no up up up no Glycine+blood 16:0/18:2-PI+blood -0.551879699 0 0 serum_aminoacids serum_phospholipids 0.00408 0.269 dn no up no no no Glycine+blood 16:0/20:4-PC+blood 0.547368421 0 0 serum_aminoacids serum_phospholipids 0.00408 0.0262 dn no up no up no Glycine+blood 16:0/20:4-PI+blood -0.606015038 0 0 serum_aminoacids serum_phospholipids 0.00408 0.558 dn no up no no no Glycine+blood 16:0/20:5-PC+blood 0 -0.549019608 0 serum_aminoacids serum_phospholipids 0.00408 0.628 dn no up no no no Glycine+blood 16:1-LPC+blood 0 0.634803922 0 serum_aminoacids serum_phospholipids 0.00408 0.0241 dn no up no up no Glycine+blood 18:0-LPC+blood -0.452631579 0 0 serum_aminoacids serum_phospholipids 0.00408 0.554 dn no up no no no Glycine+blood 18:0/16:0-PC+blood 0.491729323 0 0 serum_aminoacids serum_phospholipids 0.00408 9.64E-07 dn no up up up up Glycine+blood 18:0/18:0-PC+blood 0 0 0.447521368 serum_aminoacids serum_phospholipids 0.00408 0.426 dn no up no no no Glycine+blood 18:0/18:0-PE+blood 0 0 -0.617094017 serum_aminoacids serum_phospholipids 0.00408 0.00896 dn no up up up no Glycine+blood 18:0/18:0-PS+blood 0 -0.595588235 0 serum_aminoacids serum_phospholipids 0.00408 0.00617 dn no up no up no Glycine+blood 18:0/18:1-PC+blood 0 0 0.453675214 serum_aminoacids serum_phospholipids 0.00408 0.393 dn no up no no no Glycine+blood 18:0/18:1-PE+blood 0 0 -0.641025641 serum_aminoacids serum_phospholipids 0.00408 0.00716 dn no up up up no Glycine+blood 18:0/18:1-PG+blood 0 0 -0.572649573 serum_aminoacids serum_phospholipids 0.00408 0.000842 dn no up no up no Glycine+blood 18:0/20:3-PC+blood -0.562406015 0 0 serum_aminoacids serum_phospholipids 0.00408 0.0682 dn no up no up no Glycine+blood 18:0/22:6-PI+blood -0.562406015 0 0 serum_aminoacids serum_phospholipids 0.00408 0.425 dn no up no no no Glycine+blood 18:1/16:0-PE+blood 0 0 -0.638974359 serum_aminoacids serum_phospholipids 0.00408 0.000182 dn no up up up no Glycine+blood 18:1/16:1-PE+blood 0 0 -0.421538462 serum_aminoacids serum_phospholipids 0.00408 0.000184 dn no up up up no Glycine+blood 18:1/18:0-PE+blood 0 0 -0.654017094 serum_aminoacids serum_phospholipids 0.00408 1.39E-06 dn no up up up no Glycine+blood 18:1/18:1-PE+blood 0 0 -0.614358974 serum_aminoacids serum_phospholipids 0.00408 1.03E-05 dn no up up up no Glycine+blood 18:1/18:2-PE+blood 0 0 -0.528205128 serum_aminoacids serum_phospholipids 0.00408 0.000293 dn no up up up no Glycine+blood 18:1/20:4-PE+blood 0 0 -0.481025641 serum_aminoacids serum_phospholipids 0.00408 0.0578 dn no up up no no Glycine+blood 18:2-LPA+blood 0 0.56372549 0 serum_aminoacids serum_phospholipids 0.00408 0.00684 dn no up dn no up Glycine+blood 18:3/16:0-PE+blood 0 0 -0.401709402 serum_aminoacids serum_phospholipids 0.00408 0.00149 dn no up up up no Glycine+blood 18:3n6+blood 0 -0.534313725 0 serum_aminoacids serum_fattyacid 0.00408 0.0463 dn no up up no dn Glycine+blood 20:0/20:4-PE+blood 0 0 -0.476239316 serum_aminoacids serum_phospholipids 0.00408 0.00128 dn no up up up no Glycine+blood 20:1-LPC+blood 0 0 0.492649573 serum_aminoacids serum_phospholipids 0.00408 0.217 dn no up no no no Glycine+blood 20:1/20:4-PE+blood 0 0 -0.507008547 serum_aminoacids serum_phospholipids 0.00408 0.0042 dn no up up up no Glycine+blood 20:1+blood 0.490225564 0 0 yes serum_aminoacids serum_fattyacid 0.00408 2.56E-05 dn no up dn dn dn Glycine+blood 20:2-LPC+blood 0 0 0.405128205 serum_aminoacids serum_phospholipids 0.00408 0.119 dn no up no no up Glycine+blood 20:2/18:0-PC+blood -0.566917293 0 0 serum_aminoacids serum_phospholipids 0.00408 0.0427 dn no up no up no Glycine+blood 20:2/18:1-PE+blood 0 0 -0.474188034 serum_aminoacids serum_phospholipids 0.00408 0.00208 dn no up up up no Glycine+blood 20:3/16:0-PC+blood 0.566917293 0 0 serum_aminoacids serum_phospholipids 0.00408 0.00405 dn no up no up up Glycine+blood 20:3/18:0-PC+blood 0 0 0.66974359 serum_aminoacids serum_phospholipids 0.00408 0.296 dn no up no no no Glycine+blood 20:4-LPE+blood 0 0 0.461880342 serum_aminoacids serum_phospholipids 0.00408 0.552 dn no up no no no Glycine+blood 20:4/16:0-PE+blood 0 0 -0.402393162 serum_aminoacids serum_phospholipids 0.00408 0.00529 dn no up no up up Glycine+blood 20:5n3+blood 0 -0.50245098 0 serum_aminoacids serum_fattyacid 0.00408 0.988 dn no up no no no Glycine+blood 22:0/16:0-PE+blood 0 0 0.471452991 serum_aminoacids serum_phospholipids 0.00408 0.091 dn no up no no up Glycine+blood 22:6n3+blood -0.47518797 0 0 serum_aminoacids serum_fattyacid 0.00408 0.792 dn no up no no no Glycine+blood 24:1+blood 0 0 0.663589744 serum_aminoacids serum_fattyacid 0.00408 0.00582 dn no up no dn dn Glycine+blood 3-(3-Hydroxyphenyl)propanoic acid+stool -0.648351648 0 0 serum_aminoacids stool_cometabolism 0.00408 0.33 dn no up no no no Glycine+blood 8-HETE+blood 0 0.580882353 0 serum_aminoacids serum_ARA 0.00408 0.741 dn no up no no no Glycine+blood ACA+blood 0 0 0.449721816 serum_aminoacids serum_bileacids 0.00408 0.338 dn no up no no no Glycine+blood Adipocytokine signaling pathway 0 0.723529412 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood AGE-RAGE signaling pathway in diabetic complications 0 0.597058824 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Amoebiasis 0 0.629411765 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Amphetamine addiction 0 -0.591176471 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood AMPK signaling pathway 0 0 -0.443846154 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Arginine and proline metabolism 0 0.635294118 0 serum_aminoacids kegg 0.00408 NA dn no up no up no Glycine+blood Asthma 0 -0.505882353 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Autophagy - animal 0 0.532352941 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood B cell receptor signaling pathway 0 0.617647059 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Bifidobacterium 0 0 0.411701353 acetate-producing serum_aminoacids Genus 0.00408 0.105 dn no up no dn no Glycine+blood Bladder cancer 0 0.661764706 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood C-type lectin receptor signaling pathway 0 0.55 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood cAMP signaling pathway 0 0.552941176 0 yes serum_aminoacids kegg 0.00408 NA dn no up no up up Glycine+blood CDCA+blood 0 -0.546568627 0 serum_aminoacids serum_bileacids 0.00408 0.506 dn no up no no no Glycine+blood Cell cycle 0 -0.558823529 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Chagas disease 0 0.664705882 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Chemokine signaling pathway 0 0.658823529 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Chronic myeloid leukemia 0 0.535294118 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Coronavirus disease - COVID-19 0 -0.511764706 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Cystine+blood 0 0 0.542564103 yes serum_aminoacids serum_aminoacids 0.00408 0.00028 dn no up up up no Glycine+blood Cytosolic DNA-sensing pathway 0 0.505882353 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood d18:1-14:0-SM+blood 0 -0.539215686 0 serum_aminoacids serum_phospholipids 0.00408 0.94 dn no up no no no Glycine+blood d18:1-18:0-SM+blood 0.586466165 0 0 serum_aminoacids serum_phospholipids 0.00408 0.97 dn no up no no no Glycine+blood d18:1-18:1-SM+blood 0.511278195 0 0 serum_aminoacids serum_phospholipids 0.00408 0.916 dn no up no no no Glycine+blood d18:1-20:1-SM+blood 0.557894737 0 0 serum_aminoacids serum_phospholipids 0.00408 0.0992 dn no up no no no Glycine+blood DCA+stool 0 0 -0.622556391 serum_aminoacids stool_bileacids 0.00408 0.195 dn no up no no no Glycine+blood Epithelial cell signaling in Helicobacter pylori infection 0 0.758823529 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Estrogen signaling pathway 0 -0.673529412 -0.404615385 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Ethanolamine+blood 0.467669173 0.620098039 0 serum_aminoacids serum_aminoacids 0.00408 0.122 dn no up up no no Glycine+blood GABAergic synapse 0 0.673529412 0 serum_aminoacids kegg 0.00408 NA dn no up no up up Glycine+blood Gap junction 0 0.570588235 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood GDCA+stool 0 0 0.555723522 serum_aminoacids stool_bileacids 0.00408 0.656 dn no up no no no Glycine+blood Glucagon signaling pathway 0 -0.502941176 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Glutamatergic synapse 0 0.611764706 0 serum_aminoacids kegg 0.00408 NA dn no up no up up Glycine+blood Hematopoietic cell lineage 0 -0.617647059 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Hepatitis B 0 0.573529412 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Inflammatory mediator regulation of TRP channels 0 -0.570588235 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Insulin signaling pathway 0 -0.508823529 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Intestinal immune network for IgA production 0 -0.547058824 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood iso-LCA+stool 0 0 -0.541353383 serum_aminoacids stool_bileacids 0.00408 0.72 dn no up no no no Glycine+blood LCA+stool 0 0 -0.681203008 serum_aminoacids stool_bileacids 0.00408 0.314 dn no up no no no Glycine+blood Lipid and atherosclerosis 0 0.544117647 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Long-term depression 0 0.573529412 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Long-term potentiation 0 -0.670588235 0 serum_aminoacids kegg 0.00408 NA dn no up no no up Glycine+blood Longevity regulating pathway 0 0 -0.44 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Malaria 0 0.505882353 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood MicroRNAs in cancer 0 0 -0.402307692 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Neurotrophin signaling pathway 0 0.538235294 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood NF-kappa B signaling pathway 0 0.658823529 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Nicotinate and nicotinamide metabolism 0 0.544117647 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood NOD-like receptor signaling pathway 0 0.573529412 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Oocyte meiosis 0 -0.685294118 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood p53 signaling pathway 0 0 -0.456923077 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Pancreatic cancer 0 0 -0.550769231 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Pathways in cancer 0 0 -0.440769231 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.602941176 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Phosphatidylinositol signaling system 0 -0.623529412 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Phospholipase D signaling pathway 0 0.605882353 0 serum_aminoacids kegg 0.00408 NA dn no up no up up Glycine+blood PPAR signaling pathway 0 0.55 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Prion disease 0 -0.520588235 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Propionic acid+stool 0 0 -0.703759398 yes serum_aminoacids stool_scfa 0.00408 0.0436 dn no up dn no up Glycine+blood Prostate cancer 0 0.608823529 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Proteasome 0 -0.526470588 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Ras signaling pathway 0 -0.517647059 0 yes serum_aminoacids kegg 0.00408 NA dn no up no up up Glycine+blood Relaxin signaling pathway 0 0.567647059 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Ribosome 0 -0.511764706 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Ribosome biogenesis in eukaryotes 0 -0.658823529 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood RIG-I-like receptor signaling pathway 0 0.664705882 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood RNA degradation 0 -0.638235294 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Small cell lung cancer 0 0.511764706 0 serum_aminoacids kegg 0.00408 NA dn no up no no up Glycine+blood Spinocerebellar ataxia 0 -0.573529412 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Th1 and Th2 cell differentiation 0.489473684 0 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Thermogenesis 0 -0.505882353 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood TNF signaling pathway 0 0.6 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Toll-like receptor signaling pathway 0 0.676470588 0 yes serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Transcriptional misregulation in cancer 0 0.561764706 -0.44 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycine+blood Wnt signaling pathway 0 -0.6 0 serum_aminoacids kegg 0.00408 NA dn no up no no no Glycolysis / Gluconeogenesis Bacteroides 0 0.578063241 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Glycolysis / Gluconeogenesis Bifidobacterium 0 0.477960851 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Glycolysis / Gluconeogenesis Clostridium 0 0.568493454 0 kegg Genus NA 0.925 no no no no no no Glycolysis / Gluconeogenesis Dorea 0 0.451692626 0 kegg Genus NA 0.00362 no no no up no dn Glycolysis / Gluconeogenesis Lachnospira 0 0.423523611 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Glycolysis / Gluconeogenesis Odoribacter 0 0.504706847 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Glycolysis / Gluconeogenesis Parabacteroides 0.488695652 0 0 kegg Genus NA 4.19E-05 no no no no up up Glycolysis / Gluconeogenesis Paraprevotella 0.505831203 0 0 kegg Genus NA 0.118 no no no no no no Glycolysis / Gluconeogenesis Prevotella 0 -0.467631712 -0.427916446 acetate-producing kegg Genus NA 0.287 no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate "Alanine, aspartate and glutamate metabolism" 0.733043478 0.729249012 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Arginine and proline metabolism 0.592173913 0.700592885 0 kegg kegg NA NA no no no no up no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Arginine biosynthesis 0.762608696 0.681818182 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Ascorbate and aldarate metabolism 0 -0.416007905 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate beta-Alanine metabolism 0 -0.502964427 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Citrate cycle (TCA cycle) 0 -0.798418972 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Cysteine and methionine metabolism -0.465217391 -0.831027668 -0.435778636 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Fatty acid biosynthesis 0.673043478 0.745059289 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Fatty acid degradation 0.436521739 0.586956522 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Fatty acid elongation 0 -0.550395257 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Fructose and mannose metabolism 0 0.700592885 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Galactose metabolism 0 0.619565217 0.515572716 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Glutathione metabolism 0 -0.663043478 -0.495238095 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Glycolysis / Gluconeogenesis 0 -0.833003953 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Glycosaminoglycan degradation 0.486086957 0 0.688545689 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate N-Glycan biosynthesis -0.58 -0.609683794 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Other glycan degradation 0 0.558300395 0.547232947 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Oxidative phosphorylation 0 -0.748023715 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Pentose and glucuronate interconversions -0.624347826 -0.767786561 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Pentose phosphate pathway 0.665217391 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Phenylalanine metabolism 0 -0.664031621 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Primary bile acid biosynthesis -0.424347826 -0.650197628 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Pyrimidine metabolism 0 -0.565217391 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Starch and sucrose metabolism 0.526086957 0.669960474 0.448133848 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Steroid biosynthesis -0.603478261 -0.619565217 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Steroid hormone biosynthesis 0 -0.523715415 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Synthesis and degradation of ketone bodies -0.468695652 -0.517786561 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Taurine and hypotaurine metabolism 0 0.751976285 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Tryptophan metabolism 0 -0.633399209 0 kegg kegg NA NA no no no no up no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Tyrosine metabolism -0.411304348 -0.690711462 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.51284585 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate "Valine, leucine and isoleucine degradation" 0 -0.621541502 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Various types of N-glycan biosynthesis 0 -0.42687747 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin "Alanine, aspartate and glutamate metabolism" 0 -0.626482213 -0.52998713 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Arginine and proline metabolism 0 -0.477272727 0 kegg kegg NA NA no no no no up no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Arginine biosynthesis 0 -0.668972332 -0.584555985 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Ascorbate and aldarate metabolism 0 0.421936759 0.653281853 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin beta-Alanine metabolism 0.632173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Citrate cycle (TCA cycle) 0.595652174 0.497035573 0.586357786 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Fatty acid biosynthesis 0 -0.541501976 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Fatty acid elongation 0.456521739 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Fructose and mannose metabolism 0.459130435 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Galactose metabolism 0.409565217 0 0.555984556 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Glutathione metabolism 0 0 -0.45045045 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin "Glycine, serine and threonine metabolism" 0 0 -0.553925354 kegg kegg NA NA no no no no up no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Glycolysis / Gluconeogenesis 0.576521739 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0 0.568597169 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Glycosaminoglycan biosynthesis - keratan sulfate 0 0.57312253 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Glycosaminoglycan degradation 0 0 0.72020592 kegg kegg NA NA no no no no no up Glycosaminoglycan biosynthesis - heparan sulfate / heparin Lysine degradation 0 0.541501976 0.633719434 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Mannose type O-glycan biosynthesis 0 0.538537549 0.634234234 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin N-Glycan biosynthesis 0 0.758893281 0.443243243 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Other glycan degradation 0 0 0.656113256 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Other types of O-glycan biosynthesis 0 0 0.502187902 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Pentose and glucuronate interconversions 0.48 0.630434783 0.553667954 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Phenylalanine metabolism 0.812173913 0.583003953 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Purine metabolism 0 0 -0.41003861 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Pyrimidine metabolism 0 0.575098814 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Selenocompound metabolism 0 0 0.487516088 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Starch and sucrose metabolism 0 -0.431818182 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Steroid hormone biosynthesis 0 0 0.603861004 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Taurine and hypotaurine metabolism -0.412173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Tryptophan metabolism 0.640869565 0 0 kegg kegg NA NA no no no no up no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Tyrosine metabolism 0.543478261 0.415019763 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Ubiquinone and other terpenoid-quinone biosynthesis 0.447826087 0.542490119 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin "Valine, leucine and isoleucine degradation" 0.522608696 0.59486166 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - heparan sulfate / heparin Various types of N-glycan biosynthesis 0 0.796442688 0.473873874 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate "Alanine, aspartate and glutamate metabolism" -0.459130435 -0.544466403 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Amino sugar and nucleotide sugar metabolism -0.746956522 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Arginine and proline metabolism -0.631304348 -0.428853755 0 kegg kegg NA NA no no no no up no Glycosaminoglycan biosynthesis - keratan sulfate Arginine biosynthesis -0.494782609 -0.559288538 -0.407207207 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate beta-Alanine metabolism -0.484347826 -0.460474308 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Cysteine and methionine metabolism -0.471304348 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Fatty acid biosynthesis -0.465217391 -0.496047431 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Fatty acid degradation -0.609565217 -0.579051383 -0.406949807 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Fructose and mannose metabolism -0.57826087 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Galactose metabolism -0.56173913 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Glycolysis / Gluconeogenesis -0.610434783 0 -0.475418275 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Histidine metabolism -0.487826087 -0.561264822 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Lysine degradation 0 0.48715415 0.471042471 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Mannose type O-glycan biosynthesis 0.769565217 0.751976285 0.603346203 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Mucin type O-glycan biosynthesis -0.569565217 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate N-Glycan biosynthesis 0 0.514822134 0.520978121 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Other glycan degradation -0.543478261 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Other types of O-glycan biosynthesis 0 0 0.495495495 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Oxidative phosphorylation 0.490434783 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Pentose phosphate pathway 0 0 -0.579407979 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Primary bile acid biosynthesis -0.436521739 -0.467391304 -0.4002574 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Pyrimidine metabolism -0.593913043 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Starch and sucrose metabolism -0.674782609 -0.546442688 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Steroid hormone biosynthesis -0.577391304 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Synthesis and degradation of ketone bodies -0.416521739 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Ubiquinone and other terpenoid-quinone biosynthesis -0.413913043 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate "Valine, leucine and isoleucine degradation" -0.407826087 0 0 kegg kegg NA NA no no no no no no Glycosaminoglycan biosynthesis - keratan sulfate Various types of N-glycan biosynthesis 0 0.535573123 0.434749035 kegg kegg NA NA no no no no no no Glycosaminoglycan degradation Arginine and proline metabolism 0 0.498023715 0 kegg kegg NA NA no no up no up no Glycosaminoglycan degradation Ascorbate and aldarate metabolism 0 0 0.497554698 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Cysteine and methionine metabolism -0.51826087 -0.445652174 0 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Fructose and mannose metabolism 0 0 0.43963964 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Galactose metabolism 0 0 0.701158301 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Glutathione metabolism 0 -0.567193676 -0.498584299 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation "Glycine, serine and threonine metabolism" 0 -0.70256917 -0.579407979 kegg kegg NA NA no no up no up no Glycosaminoglycan degradation Histidine metabolism 0 0.419960474 0 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Lysine degradation 0 0 0.403346203 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Mannose type O-glycan biosynthesis 0 0 0.441956242 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation N-Glycan biosynthesis -0.593913043 0 0 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Other glycan degradation 0 0 0.720720721 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Other types of O-glycan biosynthesis -0.410434783 -0.443675889 0 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Pentose phosphate pathway 0.653913043 0.65513834 0 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Purine metabolism 0 -0.683794466 -0.497039897 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Selenocompound metabolism -0.514782609 0 0 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Starch and sucrose metabolism 0 0.496047431 0.6 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Steroid biosynthesis -0.436521739 0 0 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Steroid hormone biosynthesis 0 0 0.470785071 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Synthesis and degradation of ketone bodies -0.551304348 0 0 kegg kegg NA NA no no up no no no Glycosaminoglycan degradation Various types of N-glycan biosynthesis -0.44173913 0 0 kegg kegg NA NA no no up no no no Glycosphingolipid biosynthesis - ganglio series Amino sugar and nucleotide sugar metabolism 0 0.544466403 0.425225225 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Arachidonic acid metabolism 0.431304348 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Arginine and proline metabolism 0 -0.421936759 0 kegg kegg NA NA no no no no up no Glycosphingolipid biosynthesis - ganglio series Arginine biosynthesis 0 -0.454545455 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Ascorbate and aldarate metabolism 0 0.588932806 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Citrate cycle (TCA cycle) 0 0.651185771 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Ether lipid metabolism 0.470434783 0.490118577 0.575032175 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Fatty acid biosynthesis 0 -0.424901186 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Glycerolipid metabolism 0 0 0.444015444 kegg kegg NA NA no no no no no up Glycosphingolipid biosynthesis - ganglio series Glycerophospholipid metabolism 0 0 0.496782497 kegg kegg NA NA no no no no no up Glycosphingolipid biosynthesis - ganglio series Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.618577075 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Glycosphingolipid biosynthesis - globo and isoglobo series 0 0.46541502 0.441698842 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Glycosphingolipid biosynthesis - lacto and neolacto series 0.414782609 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0 0.465894466 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Inositol phosphate metabolism 0 0.431818182 0.478764479 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Lysine degradation 0 0.550395257 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Mannose type O-glycan biosynthesis 0 0.434782609 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Mucin type O-glycan biosynthesis 0 0.424901186 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series N-Glycan biosynthesis 0 0.639328063 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Other glycan degradation 0 0 0.420849421 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Other types of O-glycan biosynthesis 0 0.449604743 0.451737452 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Pentose and glucuronate interconversions 0 0.673913043 0.455855856 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Pentose phosphate pathway 0 -0.463438735 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Phenylalanine metabolism 0 0.592885375 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Pyrimidine metabolism 0 0.657114625 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Selenocompound metabolism 0 0.657114625 0.482368082 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Steroid biosynthesis 0 0.543478261 0.444272844 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Steroid hormone biosynthesis 0 0.496047431 0.451480051 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Synthesis and degradation of ketone bodies 0 0.661067194 0.423938224 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Tryptophan metabolism 0 0.553359684 0 kegg kegg NA NA no no no no up no Glycosphingolipid biosynthesis - ganglio series Tyrosine metabolism 0 0.509881423 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Ubiquinone and other terpenoid-quinone biosynthesis 0 0.757905138 0.534105534 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series "Valine, leucine and isoleucine degradation" 0 0.730237154 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - ganglio series Various types of N-glycan biosynthesis 0 0.695652174 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Arachidonic acid metabolism 0.419130435 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Ascorbate and aldarate metabolism 0 0.47826087 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Glycerophospholipid metabolism -0.502608696 0 0 kegg kegg NA NA no no no no no up Glycosphingolipid biosynthesis - globo and isoglobo series Glycosaminoglycan degradation 0.482608696 0 0 kegg kegg NA NA no no no no no up Glycosphingolipid biosynthesis - globo and isoglobo series Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.584347826 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Inositol phosphate metabolism -0.56173913 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Linoleic acid metabolism 0.42 0 -0.522265122 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Lysine degradation -0.517391304 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Mannose type O-glycan biosynthesis -0.428695652 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series N-Glycan biosynthesis -0.508695652 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Other types of O-glycan biosynthesis -0.513913043 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Selenocompound metabolism -0.593913043 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Steroid hormone biosynthesis 0.466956522 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Taurine and hypotaurine metabolism -0.511304348 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - globo and isoglobo series Various types of N-glycan biosynthesis -0.427826087 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series alpha-Linolenic acid metabolism -0.512173913 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Amino sugar and nucleotide sugar metabolism -0.625217391 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series beta-Alanine metabolism -0.474782609 0 -0.525096525 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Citrate cycle (TCA cycle) -0.432173913 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Cysteine and methionine metabolism -0.643478261 -0.541501976 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Ether lipid metabolism 0.62 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Fatty acid degradation -0.415652174 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Fatty acid elongation 0 0 -0.523294723 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Fructose and mannose metabolism -0.456521739 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Glutathione metabolism 0 -0.434782609 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Glycerolipid metabolism 0 0 0.45045045 kegg kegg NA NA no no no no no up Glycosphingolipid biosynthesis - lacto and neolacto series Glycerophospholipid metabolism 0.451304348 0 0 kegg kegg NA NA no no no no no up Glycosphingolipid biosynthesis - lacto and neolacto series Glycolysis / Gluconeogenesis -0.76173913 -0.546442688 -0.496782497 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.526679842 0.430888031 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Glycosaminoglycan biosynthesis - keratan sulfate 0.713913043 0.464426877 0.67953668 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Lysine degradation 0 0 0.461776062 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Mannose type O-glycan biosynthesis 0.782608696 0.438735178 0.615701416 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Mucin type O-glycan biosynthesis -0.562608696 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Other glycan degradation 0 0.418972332 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Pentose and glucuronate interconversions -0.511304348 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Phenylalanine metabolism -0.416521739 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Primary bile acid biosynthesis 0 -0.461462451 -0.500643501 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Pyrimidine metabolism -0.546956522 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Sphingolipid metabolism 0.410434783 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Steroid hormone biosynthesis -0.46 -0.483201581 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Synthesis and degradation of ketone bodies -0.436521739 0 0 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series Tryptophan metabolism -0.408695652 0 0 kegg kegg NA NA no no no no up no Glycosphingolipid biosynthesis - lacto and neolacto series Tyrosine metabolism -0.64173913 -0.536561265 -0.476962677 kegg kegg NA NA no no no no no no Glycosphingolipid biosynthesis - lacto and neolacto series "Valine, leucine and isoleucine degradation" -0.410434783 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Amino sugar and nucleotide sugar metabolism 0 0.56916996 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Glycerolipid metabolism 0.42 0.415019763 0 kegg kegg NA NA no no no no no up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis "Glycine, serine and threonine metabolism" 0 0.654150198 0 kegg kegg NA NA no no no no up no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Glycosaminoglycan degradation -0.526086957 -0.463438735 0 kegg kegg NA NA no no no no no up Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Inositol phosphate metabolism 0.597391304 0.485177866 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Lysine degradation 0.602608696 0.530632411 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis N-Glycan biosynthesis 0.668695652 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Other types of O-glycan biosynthesis 0.737391304 0.729249012 0.406177606 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Pentose phosphate pathway 0 -0.604743083 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Purine metabolism 0 0.632411067 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Selenocompound metabolism 0.643478261 0.664031621 0.44015444 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Synthesis and degradation of ketone bodies 0.534782609 0.531620553 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Taurine and hypotaurine metabolism 0.471304348 0.434782609 0.410553411 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis "Valine, leucine and isoleucine degradation" 0.411304348 0 0 kegg kegg NA NA no no no no no no Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Various types of N-glycan biosynthesis 0.567826087 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism "Alanine, aspartate and glutamate metabolism" 0.937391304 0.9743083 0.940797941 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism alpha-Linolenic acid metabolism 0.435652174 0.583003953 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Arginine and proline metabolism 0.715652174 0.868577075 0.628056628 kegg kegg NA NA no no no no up no Glyoxylate and dicarboxylate metabolism Arginine biosynthesis 0.939130435 0.993083004 0.968597169 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Ascorbate and aldarate metabolism 0 -0.528656126 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Citrate cycle (TCA cycle) 0 -0.664031621 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Cysteine and methionine metabolism 0 -0.586956522 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Ether lipid metabolism -0.560869565 -0.639328063 -0.465637066 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Fatty acid biosynthesis 0.831304348 0.938735178 0.766280566 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Fatty acid degradation 0.787826087 0.748023715 0.466151866 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Fructose and mannose metabolism 0.489565217 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Galactose metabolism 0.554782609 0.51284585 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Glutathione metabolism 0 -0.507905138 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Glycerolipid metabolism 0.417391304 0 -0.428056628 kegg kegg NA NA no no no no no up Glyoxylate and dicarboxylate metabolism Glycerophospholipid metabolism 0 0 -0.444787645 kegg kegg NA NA no no no no no up Glyoxylate and dicarboxylate metabolism Glycolysis / Gluconeogenesis 0 -0.421936759 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.672173913 0.660079051 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.675889328 -0.471042471 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.468695652 -0.565217391 -0.412097812 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Glycosphingolipid biosynthesis - ganglio series 0 -0.482213439 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Lysine degradation 0 0 -0.636293436 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Mannose type O-glycan biosynthesis 0 -0.421936759 -0.68983269 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism N-Glycan biosynthesis 0 -0.876482213 -0.571428571 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Other glycan degradation 0.447826087 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Other types of O-glycan biosynthesis 0 0 -0.535135135 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Oxidative phosphorylation -0.672173913 -0.722332016 -0.533848134 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Pentose and glucuronate interconversions 0 -0.840909091 -0.61029601 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Pentose phosphate pathway 0.496521739 0.666996047 0.807207207 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Phenylalanine metabolism 0 -0.608695652 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Pyrimidine metabolism 0.468695652 -0.684782609 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Pyruvate metabolism 0 -0.644268775 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Starch and sucrose metabolism 0.619130435 0.782608696 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Steroid biosynthesis -0.412173913 0 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Steroid hormone biosynthesis 0 -0.42687747 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Synthesis and degradation of ketone bodies 0 -0.461462451 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Tryptophan metabolism 0 -0.416996047 0 kegg kegg NA NA no no no no up no Glyoxylate and dicarboxylate metabolism Tyrosine metabolism 0 -0.549407115 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.515810277 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism "Valine, leucine and isoleucine degradation" 0 -0.654150198 0 kegg kegg NA NA no no no no no no Glyoxylate and dicarboxylate metabolism Various types of N-glycan biosynthesis 0 -0.748023715 -0.446846847 kegg kegg NA NA no no no no no no GM-CSF Eotaxin 0 -0.683116883 -0.401557286 yes serum_cytokines serum_cytokines 0.0124 0.393 up no no no no no GnRH secretion 2-Oxocarboxylic acid metabolism -0.51826087 0 0 kegg kegg NA NA no up up no no no GnRH secretion ABC transporters 0 0.60770751 0 kegg kegg NA NA no up up no up up GnRH secretion Adherens junction 0 -0.555335968 0 kegg kegg NA NA no up up no no no GnRH secretion Adipocytokine signaling pathway 0 0.447628458 0 kegg kegg NA NA no up up no no no GnRH secretion alpha-Linolenic acid metabolism -0.433913043 0 0 kegg kegg NA NA no up up no no no GnRH secretion Amino sugar and nucleotide sugar metabolism -0.648695652 0 0 kegg kegg NA NA no up up no no no GnRH secretion Antigen processing and presentation 0 -0.500988142 -0.502187902 kegg kegg NA NA no up up no no no GnRH secretion Apelin signaling pathway 0 -0.504940711 0 kegg kegg NA NA no up up no no no GnRH secretion Apoptosis 0 0.414031621 0 kegg kegg NA NA no up up no no no GnRH secretion Apoptosis - multiple species 0 0.448616601 0 kegg kegg NA NA no up up no no no GnRH secretion Arachidonic acid metabolism -0.583478261 0 -0.564221364 kegg kegg NA NA no up up no no no GnRH secretion Ascorbate and aldarate metabolism 0 -0.496047431 0 kegg kegg NA NA no up up no no no GnRH secretion Autophagy - animal 0.586956522 0.695652174 0.5997426 kegg kegg NA NA no up up no no no GnRH secretion Autophagy - other 0.474782609 0.550395257 0.637323037 kegg kegg NA NA no up up no no no GnRH secretion Axon guidance 0.447826087 0 0 kegg kegg NA NA no up up no up up GnRH secretion B cell receptor signaling pathway 0.46 0.481225296 0 kegg kegg NA NA no up up no no no GnRH secretion Basal transcription factors 0 0 0.434749035 kegg kegg NA NA no up up no no no GnRH secretion beta-Alanine metabolism -0.589565217 -0.695652174 0 kegg kegg NA NA no up up no no no GnRH secretion Biosynthesis of amino acids -0.473913043 0 -0.500643501 kegg kegg NA NA no up up no no no GnRH secretion Biosynthesis of cofactors -0.6 0 -0.464607465 kegg kegg NA NA no up up no no no GnRH secretion Biosynthesis of unsaturated fatty acids -0.492173913 -0.649209486 0 kegg kegg NA NA no up up no no no GnRH secretion Butanoate metabolism -0.60173913 -0.590909091 0 kegg kegg NA NA no up up no no no GnRH secretion C-type lectin receptor signaling pathway 0.611304348 0.538537549 0 kegg kegg NA NA no up up no no no GnRH secretion Calcium signaling pathway 0.508695652 0 0 kegg kegg NA NA no up up no up up GnRH secretion cAMP signaling pathway 0.513043478 0 0 yes kegg kegg NA NA no up up no up up GnRH secretion Carbon metabolism -0.637391304 -0.517786561 0 kegg kegg NA NA no up up no no no GnRH secretion Cell cycle 0 0 0.507078507 kegg kegg NA NA no up up no no no GnRH secretion Cholinergic synapse 0.60173913 0 0.714028314 kegg kegg NA NA no up up no no no GnRH secretion Circadian entrainment 0 -0.533596838 -0.432689833 kegg kegg NA NA no up up no up up GnRH secretion Circadian rhythm 0.582608696 0 0.622393822 kegg kegg NA NA no up up no no no GnRH secretion Citrate cycle (TCA cycle) -0.565217391 -0.677865613 0 kegg kegg NA NA no up up no no no GnRH secretion Complement and coagulation cascades 0 0 -0.481853282 kegg kegg NA NA no up up no no no GnRH secretion Cysteine and methionine metabolism -0.443478261 -0.605731225 0 kegg kegg NA NA no up up no no no GnRH secretion Drug metabolism - cytochrome P450 -0.554782609 -0.62944664 0 kegg kegg NA NA no up up no no no GnRH secretion Drug metabolism - other enzymes -0.710434783 -0.681818182 0 kegg kegg NA NA no up up no no no GnRH secretion Endocrine resistance 0.508695652 0 0 kegg kegg NA NA no up up no no no GnRH secretion ErbB signaling pathway 0.959130435 0.972332016 0.843243243 kegg kegg NA NA no up up no no no GnRH secretion Estrogen signaling pathway 0 -0.48715415 0 kegg kegg NA NA no up up no no no GnRH secretion Ether lipid metabolism 0 0 0.419305019 kegg kegg NA NA no up up no no no GnRH secretion Fatty acid elongation -0.604347826 -0.700592885 0 kegg kegg NA NA no up up no no no GnRH secretion Fc epsilon RI signaling pathway 0.766956522 0.568181818 0.466924067 kegg kegg NA NA no up up no no no GnRH secretion Ferroptosis 0 0 -0.545173745 kegg kegg NA NA no up up no no no GnRH secretion Focal adhesion 0 -0.65513834 0 kegg kegg NA NA no up up no up up GnRH secretion FoxO signaling pathway 0.48173913 0.628458498 0 kegg kegg NA NA no up up no no no GnRH secretion Fructose and mannose metabolism -0.513913043 0.568181818 0 kegg kegg NA NA no up up no no no GnRH secretion Galactose metabolism -0.426956522 0.435770751 0 kegg kegg NA NA no up up no no no GnRH secretion Gap junction 0 0 -0.438352638 kegg kegg NA NA no up up no no no GnRH secretion Glutamatergic synapse 0 0.435770751 -0.435778636 kegg kegg NA NA no up up no up up GnRH secretion Glutathione metabolism -0.436521739 -0.427865613 -0.626512227 kegg kegg NA NA no up up no no no GnRH secretion Glycerolipid metabolism 0 0.660079051 0.670785071 kegg kegg NA NA no up up no no up GnRH secretion Glycerophospholipid metabolism 0.447826087 0.522727273 0.734877735 kegg kegg NA NA no up up no no up GnRH secretion "Glycine, serine and threonine metabolism" -0.443478261 0 -0.444272844 kegg kegg NA NA no up up no up no GnRH secretion Glycolysis / Gluconeogenesis -0.677391304 -0.726284585 0 kegg kegg NA NA no up up no no no GnRH secretion Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.796442688 0.558043758 kegg kegg NA NA no up up no no no GnRH secretion Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.448695652 0 0.540797941 kegg kegg NA NA no up up no no no GnRH secretion Glycosaminoglycan biosynthesis - keratan sulfate 0.495652174 0 0.455855856 kegg kegg NA NA no up up no no no GnRH secretion Glycosaminoglycan degradation 0 0 0.496525097 kegg kegg NA NA no up up no no up GnRH secretion Glycosphingolipid biosynthesis - globo and isoglobo series -0.428695652 0 0 kegg kegg NA NA no up up no no no GnRH secretion Glycosphingolipid biosynthesis - lacto and neolacto series 0.547826087 0 0.435263835 kegg kegg NA NA no up up no no no GnRH secretion Hedgehog signaling pathway 0.65826087 0 0.776576577 kegg kegg NA NA no up up no no no GnRH secretion Hematopoietic cell lineage 0 -0.52173913 0 kegg kegg NA NA no up up no no no GnRH secretion HIF-1 signaling pathway 0 -0.460474308 0 kegg kegg NA NA no up up no no no GnRH secretion Hippo signaling pathway 0 -0.520750988 0 kegg kegg NA NA no up up no no no GnRH secretion Hippo signaling pathway - multiple species 0 0 0.57014157 kegg kegg NA NA no up up no no no GnRH secretion Inositol phosphate metabolism 0 0.574110672 0.733075933 kegg kegg NA NA no up up no no no GnRH secretion Insulin signaling pathway 0 -0.460474308 0 kegg kegg NA NA no up up no no no GnRH secretion JAK-STAT signaling pathway 0 0.720355731 0 kegg kegg NA NA no up up no no no GnRH secretion Linoleic acid metabolism -0.543478261 0 0 kegg kegg NA NA no up up no no no GnRH secretion Long-term potentiation 0 -0.528656126 0.498069498 kegg kegg NA NA no up up no no up GnRH secretion Longevity regulating pathway 0.494782609 0 0 kegg kegg NA NA no up up no no no GnRH secretion Lysine degradation 0 0.500988142 0.70965251 kegg kegg NA NA no up up no no no GnRH secretion Mannose type O-glycan biosynthesis 0.594782609 0.514822134 0.662805663 kegg kegg NA NA no up up no no no GnRH secretion MAPK signaling pathway 0 0 0.717374517 kegg kegg NA NA no up up no no no GnRH secretion Metabolism of xenobiotics by cytochrome P450 -0.605217391 -0.701581028 0 kegg kegg NA NA no up up no no no GnRH secretion Mismatch repair -0.482608696 -0.482213439 0 kegg kegg NA NA no up up no no no GnRH secretion Mitophagy - animal 0 0 -0.485714286 kegg kegg NA NA no up up no no no GnRH secretion mRNA surveillance pathway 0.507826087 0 0.59021879 kegg kegg NA NA no up up no no no GnRH secretion N-Glycan biosynthesis 0 0 0.410553411 kegg kegg NA NA no up up no no no GnRH secretion Necroptosis 0 0 -0.51969112 kegg kegg NA NA no up up no no no GnRH secretion Neurotrophin signaling pathway 0.615652174 0.568181818 0 kegg kegg NA NA no up up no no no GnRH secretion Neutrophil extracellular trap formation 0 0 -0.423166023 kegg kegg NA NA no up up no no no GnRH secretion NF-kappa B signaling pathway 0.473043478 0.657114625 0 kegg kegg NA NA no up up no no no GnRH secretion NOD-like receptor signaling pathway 0 0.449604743 0 kegg kegg NA NA no up up no no no GnRH secretion Non-homologous end-joining -0.587826087 -0.627470356 0 kegg kegg NA NA no up up no no no GnRH secretion Notch signaling pathway 0.608695652 0.705533597 0.705019305 kegg kegg NA NA no up up no no no GnRH secretion Oocyte meiosis 0 -0.637351779 0 kegg kegg NA NA no up up no no no GnRH secretion Other glycan degradation 0 0.500988142 0.611840412 kegg kegg NA NA no up up no no no GnRH secretion Other types of O-glycan biosynthesis 0 0.515810277 0.679021879 kegg kegg NA NA no up up no no no GnRH secretion Ovarian steroidogenesis 0 0 -0.424453024 kegg kegg NA NA no up up no up up GnRH secretion Oxidative phosphorylation 0 -0.422924901 0 kegg kegg NA NA no up up no no no GnRH secretion Oxytocin signaling pathway 0 -0.518774704 -0.442471042 kegg kegg NA NA no up up no no no GnRH secretion p53 signaling pathway 0.517391304 0.448616601 0 kegg kegg NA NA no up up no no no GnRH secretion Pentose and glucuronate interconversions -0.663478261 -0.554347826 0 kegg kegg NA NA no up up no no no GnRH secretion Phenylalanine metabolism -0.562608696 -0.584980237 0 kegg kegg NA NA no up up no no no GnRH secretion Phosphatidylinositol signaling system 0.650434783 0 0.785842986 kegg kegg NA NA no up up no no no GnRH secretion Phospholipase D signaling pathway 0.532173913 0.684782609 0 kegg kegg NA NA no up up no up up GnRH secretion Phototransduction 0 -0.865612648 0 kegg kegg NA NA no up up no no no GnRH secretion Platelet activation -0.41826087 -0.537549407 0 kegg kegg NA NA no up up no no no GnRH secretion Platinum drug resistance 0.475652174 0.53458498 0.46023166 kegg kegg NA NA no up up no no no GnRH secretion Porphyrin and chlorophyll metabolism -0.435652174 0 -0.503989704 kegg kegg NA NA no up up no no no GnRH secretion Primary bile acid biosynthesis -0.528695652 -0.741106719 0 kegg kegg NA NA no up up no no no GnRH secretion Progesterone-mediated oocyte maturation 0.495652174 0.567193676 0.784555985 kegg kegg NA NA no up up no no no GnRH secretion Prolactin signaling pathway 0.720869565 0.622529644 0.522779923 kegg kegg NA NA no up up no no no GnRH secretion Propanoate metabolism -0.493043478 -0.635375494 0 kegg kegg NA NA no up up no no no GnRH secretion Proteasome 0 -0.740118577 0 kegg kegg NA NA no up up no no no GnRH secretion Protein export 0 -0.54743083 0 kegg kegg NA NA no up up no no no GnRH secretion Pyrimidine metabolism -0.503478261 0 0 kegg kegg NA NA no up up no no no GnRH secretion Pyruvate metabolism -0.451304348 -0.624505929 0 kegg kegg NA NA no up up no no no GnRH secretion Ras signaling pathway 0 0 0.567052767 yes kegg kegg NA NA no up up no up up GnRH secretion Regulation of actin cytoskeleton -0.65826087 -0.786561265 0 kegg kegg NA NA no up up no no no GnRH secretion Relaxin signaling pathway 0.467826087 0.549407115 0 kegg kegg NA NA no up up no no no GnRH secretion Renin secretion 0 -0.522727273 0 kegg kegg NA NA no up up no no no GnRH secretion Retinol metabolism -0.506956522 0 0 kegg kegg NA NA no up up no no no GnRH secretion Retrograde endocannabinoid signaling 0 -0.504940711 0 kegg kegg NA NA no up up no no up GnRH secretion Ribosome 0 -0.441699605 0 kegg kegg NA NA no up up no no no GnRH secretion Ribosome biogenesis in eukaryotes 0 0 0.421364221 kegg kegg NA NA no up up no no no GnRH secretion RIG-I-like receptor signaling pathway 0.426086957 0.632411067 0 kegg kegg NA NA no up up no no no GnRH secretion RNA degradation 0.493913043 0 0.572715573 kegg kegg NA NA no up up no no no GnRH secretion Selenocompound metabolism 0 0 0.523809524 kegg kegg NA NA no up up no no no GnRH secretion Serotonergic synapse 0 0 -0.402316602 kegg kegg NA NA no up up no no no GnRH secretion Signaling pathways regulating pluripotency of stem cells 0.86 0.766798419 0.80978121 kegg kegg NA NA no up up no no no GnRH secretion SNARE interactions in vesicular transport 0 0.4743083 0 kegg kegg NA NA no up up no no no GnRH secretion Sphingolipid signaling pathway 0.706086957 0 0.69034749 kegg kegg NA NA no up up no no no GnRH secretion Spliceosome 0 0.514822134 0.471042471 kegg kegg NA NA no up up no no no GnRH secretion Steroid biosynthesis 0 -0.604743083 0 kegg kegg NA NA no up up no no no GnRH secretion Steroid hormone biosynthesis -0.716521739 -0.542490119 0 kegg kegg NA NA no up up no no no GnRH secretion Sulfur metabolism -0.615652174 -0.466403162 -0.492664093 kegg kegg NA NA no up up no no no GnRH secretion T cell receptor signaling pathway 0 0.549407115 0 kegg kegg NA NA no up up no no no GnRH secretion Taste transduction 0 0 0.715572716 kegg kegg NA NA no up up no no up GnRH secretion Taurine and hypotaurine metabolism 0.56 0.800395257 0.519433719 kegg kegg NA NA no up up no no no GnRH secretion TGF-beta signaling pathway 0 -0.551383399 0.50990991 kegg kegg NA NA no up up no no no GnRH secretion Thermogenesis 0 -0.422924901 0 kegg kegg NA NA no up up no no no GnRH secretion Thiamine metabolism -0.46 -0.56027668 0 kegg kegg NA NA no up up no no no GnRH secretion Thyroid hormone synthesis 0 0 -0.457400257 kegg kegg NA NA no up up no no no GnRH secretion Tight junction -0.628695652 -0.70256917 -0.475418275 kegg kegg NA NA no up up no no no GnRH secretion TNF signaling pathway 0.627826087 0.705533597 0 kegg kegg NA NA no up up no no no GnRH secretion Toll-like receptor signaling pathway 0.533043478 0.492094862 0 yes kegg kegg NA NA no up up no no no GnRH secretion Tryptophan metabolism -0.576521739 -0.7243083 0 kegg kegg NA NA no up up no up no GnRH secretion Tyrosine metabolism -0.590434783 -0.583003953 0 kegg kegg NA NA no up up no no no GnRH secretion Ubiquinone and other terpenoid-quinone biosynthesis -0.546956522 -0.449604743 0 kegg kegg NA NA no up up no no no GnRH secretion Ubiquitin mediated proteolysis 0 0 -0.478507079 kegg kegg NA NA no up up no no no GnRH secretion "Valine, leucine and isoleucine degradation" -0.52 -0.558300395 0 kegg kegg NA NA no up up no no no GnRH secretion Various types of N-glycan biosynthesis 0 0 0.405920206 kegg kegg NA NA no up up no no no GnRH secretion Vascular smooth muscle contraction 0 -0.545454545 0 kegg kegg NA NA no up up no no no GnRH secretion VEGF signaling pathway 0.839130435 0.81027668 0.756756757 kegg kegg NA NA no up up no no no GnRH secretion Viral protein interaction with cytokine and cytokine receptor 0 0 -0.579150579 kegg kegg NA NA no up up no no no GnRH secretion Wnt signaling pathway 0 0 0.670785071 kegg kegg NA NA no up up no no no GnRH signaling pathway 2-Oxocarboxylic acid metabolism -0.440869565 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway ABC transporters -0.687826087 0 0 kegg kegg NA NA no no no no up up GnRH signaling pathway Adrenergic signaling in cardiomyocytes 0.763478261 0.68083004 0.83037323 kegg kegg NA NA no no no no no up GnRH signaling pathway alpha-Linolenic acid metabolism -0.78 0 -0.729214929 kegg kegg NA NA no no no no no no GnRH signaling pathway Amino sugar and nucleotide sugar metabolism -0.565217391 0 -0.628828829 kegg kegg NA NA no no no no no no GnRH signaling pathway Aminoacyl-tRNA biosynthesis -0.436521739 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway AMPK signaling pathway 0 0.618577075 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Antigen processing and presentation 0 -0.46541502 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Apoptosis -0.472173913 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Arginine and proline metabolism -0.53826087 0 0 kegg kegg NA NA no no no no up no GnRH signaling pathway Ascorbate and aldarate metabolism 0 0 -0.588674389 kegg kegg NA NA no no no no no no GnRH signaling pathway beta-Alanine metabolism -0.560869565 0 -0.504247104 kegg kegg NA NA no no no no no no GnRH signaling pathway Biosynthesis of amino acids -0.537391304 -0.626482213 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Butanoate metabolism -0.493913043 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Calcium signaling pathway 0.745217391 0.669960474 0.75984556 kegg kegg NA NA no no no no up up GnRH signaling pathway cAMP signaling pathway 0.552173913 0 0.678764479 yes kegg kegg NA NA no no no no up up GnRH signaling pathway Carbon metabolism -0.519130435 -0.666007905 -0.532046332 kegg kegg NA NA no no no no no no GnRH signaling pathway Cardiac muscle contraction 0 0.484189723 0 kegg kegg NA NA no no no no no up GnRH signaling pathway Cell adhesion molecules 0 -0.672924901 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Cellular senescence 0 -0.458498024 0 kegg kegg NA NA no no no no no no GnRH signaling pathway cGMP-PKG signaling pathway 0 -0.482213439 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Circadian entrainment 0.612173913 0.443675889 0.743886744 kegg kegg NA NA no no no no up up GnRH signaling pathway Circadian rhythm 0 0.529644269 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Citrate cycle (TCA cycle) -0.422608696 0 -0.413127413 kegg kegg NA NA no no no no no no GnRH signaling pathway Clostridium 0 -0.475782156 0 kegg Genus NA 0.925 no no no no no no GnRH signaling pathway Collinsella 0 -0.450224263 0 kegg Genus NA 0.128 no no no no no no GnRH signaling pathway Complement and coagulation cascades -0.448695652 -0.523715415 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Dopaminergic synapse 0.732173913 0.586956522 0.898326898 kegg kegg NA NA no no no no up no GnRH signaling pathway Dorea -0.467826087 0 0 kegg Genus NA 0.00362 no no no up no dn GnRH signaling pathway Drug metabolism - other enzymes -0.533913043 0 -0.509137709 kegg kegg NA NA no no no no no no GnRH signaling pathway ECM-receptor interaction 0 0 0.445045045 kegg kegg NA NA no no no no up up GnRH signaling pathway Endocrine resistance 0.793043478 0.853754941 0.713256113 kegg kegg NA NA no no no no no no GnRH signaling pathway Endocytosis 0 -0.662055336 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Fatty acid degradation -0.64 0 -0.709395109 kegg kegg NA NA no no no no no no GnRH signaling pathway Fatty acid elongation 0 -0.441699605 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Fatty acid metabolism -0.591304348 -0.461462451 -0.576061776 kegg kegg NA NA no no no no no no GnRH signaling pathway Fc gamma R-mediated phagocytosis -0.568695652 -0.636363636 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Ferroptosis 0.526956522 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Fructose and mannose metabolism -0.594782609 0 -0.656628057 kegg kegg NA NA no no no no no no GnRH signaling pathway Galactose metabolism -0.630434783 0 -0.614671815 kegg kegg NA NA no no no no no no GnRH signaling pathway Gap junction 0.693043478 0.614624506 0.549034749 kegg kegg NA NA no no no no no no GnRH signaling pathway Glutamatergic synapse 0.715652174 0.421936759 0.515057915 kegg kegg NA NA no no no no up up GnRH signaling pathway Glycerolipid metabolism -0.466956522 0 0 kegg kegg NA NA no no no no no up GnRH signaling pathway "Glycine, serine and threonine metabolism" 0 0.451581028 0 kegg kegg NA NA no no no no up no GnRH signaling pathway Glycolysis / Gluconeogenesis -0.493043478 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0.549565217 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Glycosaminoglycan degradation 0 -0.596837945 -0.502960103 kegg kegg NA NA no no no no no up GnRH signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.453557312 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Glyoxylate and dicarboxylate metabolism -0.486956522 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Hippo signaling pathway - multiple species 0 0 -0.407464607 kegg kegg NA NA no no no no no no GnRH signaling pathway Histidine metabolism -0.590434783 0 -0.722779923 kegg kegg NA NA no no no no no no GnRH signaling pathway IL-17 signaling pathway 0 -0.429841897 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Inflammatory mediator regulation of TRP channels 0.823478261 0.662055336 0.833976834 kegg kegg NA NA no no no no no no GnRH signaling pathway Inositol phosphate metabolism -0.425217391 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Insulin secretion 0.796521739 0.928853755 0.863577864 yes kegg kegg NA NA no no no no up up GnRH signaling pathway Long-term depression 0.811304348 0.660079051 0.778378378 kegg kegg NA NA no no no no no no GnRH signaling pathway Long-term potentiation 0.466086957 0 0 kegg kegg NA NA no no no no no up GnRH signaling pathway Longevity regulating pathway 0.505217391 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Longevity regulating pathway - multiple species 0 -0.678853755 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Lysosome 0 -0.612648221 -0.489317889 kegg kegg NA NA no no no no no no GnRH signaling pathway Metabolism of xenobiotics by cytochrome P450 0 0 -0.400514801 kegg kegg NA NA no no no no no no GnRH signaling pathway Mitophagy - animal 0.619130435 0.609683794 0 kegg kegg NA NA no no no no no no GnRH signaling pathway mRNA surveillance pathway 0.420869565 0.483201581 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Natural killer cell mediated cytotoxicity 0 -0.531620553 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Necroptosis 0.62173913 0.450592885 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Neuroactive ligand-receptor interaction -0.506086957 -0.717391304 -0.404890605 kegg kegg NA NA no no no up up up GnRH signaling pathway Neutrophil extracellular trap formation -0.488695652 -0.557312253 0 kegg kegg NA NA no no no no no no GnRH signaling pathway NF-kappa B signaling pathway -0.488695652 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Nicotinate and nicotinamide metabolism -0.507826087 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway NOD-like receptor signaling pathway -0.623478261 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Non-homologous end-joining -0.440869565 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Odoribacter 0 -0.501239774 0 butyrate-producing kegg Genus NA 0.798 no no no no no no GnRH signaling pathway Olfactory transduction 0 -0.506916996 -0.461003861 kegg kegg NA NA no no no no no no GnRH signaling pathway Osteoclast differentiation -0.62173913 -0.496047431 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Other glycan degradation -0.51826087 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Other types of O-glycan biosynthesis 0 0.494071146 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Oxidative phosphorylation 0 0.455533597 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Pantothenate and CoA biosynthesis -0.455652174 -0.453557312 -0.608494208 kegg kegg NA NA no no no no no dn GnRH signaling pathway Paraprevotella -0.494666023 0 0 kegg Genus NA 0.118 no no no no no no GnRH signaling pathway Pentose phosphate pathway -0.422608696 -0.606719368 -0.459202059 kegg kegg NA NA no no no no no no GnRH signaling pathway Peroxisome -0.593043478 -0.526679842 -0.428828829 kegg kegg NA NA no no no no no no GnRH signaling pathway Phagosome 0 -0.641304348 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Phenylalanine metabolism 0 0 -0.428828829 kegg kegg NA NA no no no no no no GnRH signaling pathway Phosphatidylinositol signaling system 0.482608696 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway PPAR signaling pathway 0 -0.451581028 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Prevotella -0.434253932 0 0 kegg Genus NA 0.367 no no no no no no GnRH signaling pathway Prevotella 0 0 0.459723912 acetate-producing kegg Genus NA 0.287 no no no no no no GnRH signaling pathway Proteasome 0 0 -0.452767053 kegg kegg NA NA no no no no no no GnRH signaling pathway Pyrimidine metabolism -0.484347826 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Renin-angiotensin system 0 -0.583992095 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Retinol metabolism -0.454782609 0 -0.498326898 kegg kegg NA NA no no no no no no GnRH signaling pathway Ribosome 0.433043478 0.434782609 0 kegg kegg NA NA no no no no no no GnRH signaling pathway RNA polymerase 0 0.420948617 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Sarcina 0 -0.444554224 0 kegg Genus NA 0.0703 no no no no no no GnRH signaling pathway Serotonergic synapse 0.470434783 0 0.444272844 kegg kegg NA NA no no no no no no GnRH signaling pathway SNARE interactions in vesicular transport -0.506086957 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Sphingolipid metabolism 0 0 -0.51016731 kegg kegg NA NA no no no no no no GnRH signaling pathway Sphingolipid signaling pathway 0 -0.427865613 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Starch and sucrose metabolism -0.710434783 0 -0.683912484 kegg kegg NA NA no no no no no no GnRH signaling pathway Steroid hormone biosynthesis 0 0 -0.463063063 kegg kegg NA NA no no no no no no GnRH signaling pathway Synaptic vesicle cycle 0 -0.588932806 -0.618790219 kegg kegg NA NA no no no no up up GnRH signaling pathway Thermogenesis 0 0.482213439 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Tryptophan metabolism -0.550434783 0 -0.42985843 kegg kegg NA NA no no no no up no GnRH signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.462608696 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Ubiquitin mediated proteolysis 0.645217391 0.623517787 0 kegg kegg NA NA no no no no no no GnRH signaling pathway "Valine, leucine and isoleucine degradation" -0.463478261 0 0 kegg kegg NA NA no no no no no no GnRH signaling pathway Vascular smooth muscle contraction 0.690434783 0.43972332 0.761132561 kegg kegg NA NA no no no no no no GnRH signaling pathway Wnt signaling pathway 0.434782609 0 0 kegg kegg NA NA no no no no no no GPC+blood 14:0/16:0-PC+blood 0 -0.56372549 0 serum_choline serum_phospholipids 0.00427 0.0358 no up up no up no GPC+blood 14:0/18:0-PC+blood -0.47518797 0 0 serum_choline serum_phospholipids 0.00427 0.00289 no up up up up no GPC+blood 16:0-LPC+blood 0.497744361 0 0.446153846 serum_choline serum_phospholipids 0.00427 0.00456 no up up up up no GPC+blood 16:0/16:1-PC+blood -0.482706767 0 0 serum_choline serum_phospholipids 0.00427 0.00283 no up up up up no GPC+blood 16:1-LPC+blood 0.580451128 0 0 serum_choline serum_phospholipids 0.00427 0.0241 no up up no up no GPC+blood 18:0-LPC+blood 0 0 0.557606838 serum_choline serum_phospholipids 0.00427 0.554 no up up no no no GPC+blood 18:0-LPE+blood 0 0 0.420854701 serum_choline serum_phospholipids 0.00427 0.491 no up up no no no GPC+blood 18:0/18:0-PS+blood 0 -0.531862745 0 serum_choline serum_phospholipids 0.00427 0.00617 no up up no up no GPC+blood 18:0+blood 0 -0.541666667 0 serum_choline serum_fattyacid 0.00427 0.344 no up up no no no GPC+blood 18:1/18:0-PS+blood 0 -0.534313725 0 serum_choline serum_phospholipids 0.00427 0.193 no up up no no no GPC+blood 18:1/18:1-PG+blood 0 -0.568627451 0 serum_choline serum_phospholipids 0.00427 0.00352 no up up no up up GPC+blood 18:1/18:2-PI+blood 0.497744361 0 0 serum_choline serum_phospholipids 0.00427 0.0164 no up up dn no up GPC+blood 18:2-LPA+blood 0 0.588235294 0 serum_choline serum_phospholipids 0.00427 0.00684 no up up dn no up GPC+blood 20:1-LPA+blood 0.613533835 0 0 serum_choline serum_phospholipids 0.00427 0.0187 no up up dn dn no GPC+blood 24:0+blood 0 0 -0.517948718 serum_choline serum_fattyacid 0.00427 0.034 no up up dn no up GPC+blood 8-HETE+blood 0 0.526960784 0 serum_choline serum_ARA 0.00427 0.741 no up up no no no GPC+blood 9-HODE+blood 0.487218045 0 0 serum_choline serum_ARA 0.00427 0.297 no up up no no no GPC+blood ACA+stool 0 0 0.487119845 serum_choline stool_bileacids 0.00427 0.417 no up up no no no GPC+blood Adipocytokine signaling pathway -0.485964912 0 0 serum_choline kegg 0.00427 NA no up up no no no GPC+blood Alistipes 0 -0.49049672 0 serum_choline Genus 0.00427 0.0114 no up up no up no GPC+blood Betaine+blood 0 0.691176471 0 serum_choline serum_choline 0.00427 0.857 no up up no no no GPC+blood Butyricimonas 0 -0.510474647 0 butyrate-producing serum_choline Genus 0.00427 0.17 no up up no no no GPC+blood C-type lectin receptor signaling pathway 0 0 0.459230769 serum_choline kegg 0.00427 NA no up up no no no GPC+blood Choline+blood 0 0.830882353 0 serum_choline serum_choline 0.00427 0.0395 no up up no up no GPC+blood Clostridium 0.478375363 0 0 serum_choline Genus 0.00427 0.925 no up up no no no GPC+blood Colorectal cancer 0 -0.555882353 0 serum_choline kegg 0.00427 NA no up up no no no GPC+blood Creatinine+blood 0 0.568627451 0 serum_choline serum_choline 0.00427 0.437 no up up no no no GPC+blood Cysteine+blood 0.470676692 0 0 yes serum_choline serum_aminoacids 0.00427 1.81E-07 no up up dn up up GPC+blood d18:1-20:0-SM+blood 0 0 0.411282051 serum_choline serum_phospholipids 0.00427 0.933 no up up no no no GPC+blood DMG+blood 0 0.490196078 0.407179487 serum_choline serum_choline 0.00427 0.909 no up up no no no GPC+blood Gastric cancer 0 -0.505882353 0 serum_choline kegg 0.00427 NA no up up no no no GPC+blood Gemmiger -0.485714286 0 0 butyrate-producing serum_choline Genus 0.00427 0.595 no up up no no no GPC+blood Glioma 0 -0.564705882 0 serum_choline kegg 0.00427 NA no up up no no no GPC+blood Glycine+blood 0 0.536764706 0 serum_choline serum_aminoacids 0.00427 0.00408 no up up dn no up GPC+blood HCA+stool 0 0 -0.467669173 serum_choline stool_bileacids 0.00427 0.155 no up up no no no GPC+blood Hepatitis B 0 0 0.425384615 serum_choline kegg 0.00427 NA no up up no no no GPC+blood Hepatitis C 0 0 0.432307692 serum_choline kegg 0.00427 NA no up up no no no GPC+blood Oscillospira -0.780451128 0 0 LPS-producing serum_choline Genus 0.00427 0.62 no up up no no no GPC+blood Pancreatic cancer 0.459649123 -0.673529412 0 serum_choline kegg 0.00427 NA no up up no no no GPC+blood Phosphatidylinositol signaling system 0 -0.652941176 0 serum_choline kegg 0.00427 NA no up up no no no GPC+blood Platinum drug resistance 0 -0.502941176 0 serum_choline kegg 0.00427 NA no up up no no no GPC+blood Ras signaling pathway 0.605263158 0 0 yes serum_choline kegg 0.00427 NA no up up no up up GPC+blood RIG-I-like receptor signaling pathway 0 0 0.494615385 serum_choline kegg 0.00427 NA no up up no no no GPC+blood Signaling pathways regulating pluripotency of stem cells 0 -0.505882353 0 serum_choline kegg 0.00427 NA no up up no no no GPC+blood Transcriptional misregulation in cancer 0 0 0.41 serum_choline kegg 0.00427 NA no up up no no no Graft-versus-host disease 2-Oxocarboxylic acid metabolism 0.48173913 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Adrenergic signaling in cardiomyocytes 0 -0.43972332 0 kegg kegg NA NA no no no no no up Graft-versus-host disease Aldosterone synthesis and secretion 0 -0.612648221 0 kegg kegg NA NA no no no no up up Graft-versus-host disease Allograft rejection 0.99826087 1 0.996911197 kegg kegg NA NA no no no no no no Graft-versus-host disease Alzheimer disease -0.510434783 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Amino sugar and nucleotide sugar metabolism 0 0 -0.416216216 kegg kegg NA NA no no no no no no Graft-versus-host disease Amphetamine addiction -0.423478261 -0.684782609 0 kegg kegg NA NA no no no no no no Graft-versus-host disease AMPK signaling pathway 0 -0.665019763 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Amyotrophic lateral sclerosis -0.456521739 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Antifolate resistance 0 0 -0.465122265 kegg kegg NA NA no no no no no no Graft-versus-host disease Antigen processing and presentation 0.493913043 0.533596838 0.662033462 kegg kegg NA NA no no no no no no Graft-versus-host disease Apelin signaling pathway -0.447826087 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Apoptosis 0 0.710474308 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Apoptosis - multiple species 0 0 -0.563191763 kegg kegg NA NA no no no no no no Graft-versus-host disease Asthma 0.462608696 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Autoimmune thyroid disease 0.99826087 1 0.996911197 kegg kegg NA NA no no no no no no Graft-versus-host disease Autophagy - other -0.574782609 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease B cell receptor signaling pathway 0 0.472332016 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Bacterial invasion of epithelial cells 0.411304348 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Bacteroides 0.420869565 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Graft-versus-host disease Basal transcription factors -0.580869565 -0.584980237 -0.527670528 kegg kegg NA NA no no no no no no Graft-versus-host disease Base excision repair 0 -0.530632411 -0.427027027 kegg kegg NA NA no no no no no no Graft-versus-host disease Biosynthesis of amino acids 0.574782609 0.587944664 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Biosynthesis of cofactors 0 -0.843873518 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Butyricicoccus 0 0 0.496522035 butyrate-producing kegg Genus NA 0.852 no no no no no no Graft-versus-host disease C-type lectin receptor signaling pathway 0 0.523715415 0 kegg kegg NA NA no no no no no no Graft-versus-host disease cAMP signaling pathway -0.453913043 0 0 yes kegg kegg NA NA no no no no up up Graft-versus-host disease Carbon metabolism 0.495652174 0.475296443 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Cardiac muscle contraction -0.432173913 0 0 kegg kegg NA NA no no no no no up Graft-versus-host disease Cell adhesion molecules 0.959130435 0.960474308 0.949292149 kegg kegg NA NA no no no no no no Graft-versus-host disease Cell cycle -0.589565217 -0.612648221 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Cellular senescence 0.825217391 0.935770751 0.888803089 kegg kegg NA NA no no no no no no Graft-versus-host disease Central carbon metabolism in cancer 0 0 -0.438610039 kegg kegg NA NA no no no no no no Graft-versus-host disease cGMP-PKG signaling pathway 0 0.528656126 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Chemical carcinogenesis - receptor activation -0.54173913 -0.588932806 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Chemokine signaling pathway 0 0.451581028 0.475160875 kegg kegg NA NA no no no no no no Graft-versus-host disease Cholesterol metabolism 0 0.708498024 0 yes kegg kegg NA NA no no no no no up Graft-versus-host disease Circadian rhythm -0.497391304 -0.504940711 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Cocaine addiction 0 -0.522727273 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Complement and coagulation cascades 0.52 0.57312253 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Cortisol synthesis and secretion 0 -0.627470356 0 kegg kegg NA NA no no no no no up Graft-versus-host disease Cushing syndrome 0 -0.698616601 0 kegg kegg NA NA no no no no no up Graft-versus-host disease Cytosolic DNA-sensing pathway 0 0 0.485199485 kegg kegg NA NA no no no no no no Graft-versus-host disease DNA replication 0 -0.418972332 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Dopaminergic synapse -0.436521739 -0.524703557 0 kegg kegg NA NA no no no no up no Graft-versus-host disease Endocrine and other factor-regulated calcium reabsorption 0 -0.468379447 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Endocrine resistance 0 -0.563241107 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Endocytosis 0.827826087 0.944664032 0.909137709 kegg kegg NA NA no no no no no no Graft-versus-host disease Epithelial cell signaling in Helicobacter pylori infection 0 0.577075099 0.547232947 kegg kegg NA NA no no no no no no Graft-versus-host disease Epstein-Barr virus infection 0.496521739 0.544466403 0.746460746 kegg kegg NA NA no no no no no no Graft-versus-host disease Estrogen signaling pathway -0.407826087 -0.490118577 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Ether lipid metabolism -0.502608696 -0.698616601 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Fanconi anemia pathway 0 -0.563241107 -0.457657658 kegg kegg NA NA no no no no no no Graft-versus-host disease Fc epsilon RI signaling pathway 0 0.576086957 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Fc gamma R-mediated phagocytosis 0 0.546442688 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Focal adhesion 0.405217391 0 0 kegg kegg NA NA no no no no up up Graft-versus-host disease Folate biosynthesis -0.451304348 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease FoxO signaling pathway 0 0 -0.529214929 kegg kegg NA NA no no no no no no Graft-versus-host disease Glucagon signaling pathway 0 -0.62944664 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Glutathione metabolism 0 -0.540513834 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Glycerophospholipid metabolism -0.513043478 -0.472332016 0 kegg kegg NA NA no no no no no up Graft-versus-host disease "Glycine, serine and threonine metabolism" 0 -0.780632411 0 kegg kegg NA NA no no no no up no Graft-versus-host disease Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.443478261 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Glycosaminoglycan degradation 0 0.624505929 0 kegg kegg NA NA no no no no no up Graft-versus-host disease Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.752964427 0 kegg kegg NA NA no no no no no no Graft-versus-host disease GnRH signaling pathway 0 -0.553359684 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Hedgehog signaling pathway 0 -0.446640316 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Herpes simplex virus 1 infection 0.428695652 0.53458498 0.702702703 kegg kegg NA NA no no no no no no Graft-versus-host disease Homologous recombination 0 -0.505928854 -0.530501931 kegg kegg NA NA no no no no no no Graft-versus-host disease Human cytomegalovirus infection 0.443478261 0.535573123 0.694465894 kegg kegg NA NA no no no no no dn Graft-versus-host disease Human immunodeficiency virus 1 infection 0 0.53458498 0.675418275 kegg kegg NA NA no no no no no no Graft-versus-host disease Human papillomavirus infection 0.833913043 0.90513834 0.83989704 kegg kegg NA NA no no no no no no Graft-versus-host disease Human T-cell leukemia virus 1 infection 0.494782609 0.519762846 0.727927928 kegg kegg NA NA no no no no no no Graft-versus-host disease Huntington disease -0.479130435 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease IL-17 signaling pathway 0 0.563241107 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Inflammatory mediator regulation of TRP channels 0 -0.421936759 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Influenza A 0.604347826 0.770750988 0.543371943 kegg kegg NA NA no no no no no no Graft-versus-host disease Insulin resistance -0.482608696 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Insulin secretion 0 -0.570158103 0 yes kegg kegg NA NA no no no no up up Graft-versus-host disease Insulin signaling pathway -0.443478261 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Leukocyte transendothelial migration 0.52 0.506916996 0.435521236 kegg kegg NA NA no no no no no no Graft-versus-host disease Long-term potentiation -0.455652174 0 0 kegg kegg NA NA no no no no no up Graft-versus-host disease Longevity regulating pathway 0 -0.471343874 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Lysosome 0 0.704545455 0 kegg kegg NA NA no no no no no no Graft-versus-host disease MAPK signaling pathway -0.6 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Maturity onset diabetes of the young 0 -0.513833992 0 kegg kegg NA NA no no no no up no Graft-versus-host disease Measles -0.507826087 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Mismatch repair 0 -0.545454545 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Mitophagy - animal 0 -0.491106719 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Morphine addiction 0 -0.428853755 0 kegg kegg NA NA no no no no up up Graft-versus-host disease mRNA surveillance pathway -0.593913043 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Natural killer cell mediated cytotoxicity 0.825217391 0.95256917 0.908880309 kegg kegg NA NA no no no no no no Graft-versus-host disease Neuroactive ligand-receptor interaction 0 0.615612648 0 kegg kegg NA NA no no no up up up Graft-versus-host disease Neurotrophin signaling pathway 0 0.492094862 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Neutrophil extracellular trap formation 0 0.612648221 0 kegg kegg NA NA no no no no no no Graft-versus-host disease NOD-like receptor signaling pathway 0 0.490118577 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Non-alcoholic fatty liver disease -0.509565217 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Nucleotide excision repair 0 -0.589920949 -0.526126126 kegg kegg NA NA no no no no no no Graft-versus-host disease One carbon pool by folate 0 -0.546442688 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Oocyte meiosis -0.513043478 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Osteoclast differentiation 0 0.588932806 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Other types of O-glycan biosynthesis -0.544347826 -0.53458498 -0.41029601 kegg kegg NA NA no no no no no no Graft-versus-host disease Ovarian steroidogenesis 0 -0.457509881 0 kegg kegg NA NA no no no no up up Graft-versus-host disease Oxidative phosphorylation -0.463478261 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease p53 signaling pathway -0.519130435 -0.491106719 -0.562419562 kegg kegg NA NA no no no no no no Graft-versus-host disease "Parathyroid hormone synthesis, secretion and action" -0.414782609 -0.434782609 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Pathogenic Escherichia coli infection 0 0.7756917 0.482110682 kegg kegg NA NA no no no no no no Graft-versus-host disease Pathways in cancer -0.564347826 0 -0.442213642 kegg kegg NA NA no no no no no no Graft-versus-host disease Pentose phosphate pathway 0.443478261 0.663043478 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Pertussis 0 0.649209486 0 kegg kegg NA NA no no no no no dn Graft-versus-host disease Phagosome 0.890434783 0.916007905 0.818018018 kegg kegg NA NA no no no no no no Graft-versus-host disease PI3K-Akt signaling pathway -0.540869565 0 0 yes kegg kegg NA NA no no no no up up Graft-versus-host disease Platinum drug resistance 0 0 -0.577091377 kegg kegg NA NA no no no no no no Graft-versus-host disease Porphyrin and chlorophyll metabolism 0 -0.745059289 0 kegg kegg NA NA no no no no no no Graft-versus-host disease PPAR signaling pathway 0 0.457509881 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Prion disease -0.456521739 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Progesterone-mediated oocyte maturation -0.428695652 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Prolactin signaling pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Protein digestion and absorption 0.419130435 0.456521739 0 yes kegg kegg NA NA no no no no up up Graft-versus-host disease Protein export -0.535652174 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Protein processing in endoplasmic reticulum 0 -0.471343874 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Purine metabolism 0 -0.751976285 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Pyrimidine metabolism 0 -0.423913043 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Pyruvate metabolism 0 -0.431818182 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Renin-angiotensin system 0 0.677865613 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Retinol metabolism 0 -0.414031621 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Retrograde endocannabinoid signaling -0.51826087 0 0 kegg kegg NA NA no no no no no up Graft-versus-host disease Rheumatoid arthritis 0.66 0.739130435 0.428828829 kegg kegg NA NA no no no no no no Graft-versus-host disease Ribosome biogenesis in eukaryotes -0.424347826 -0.536561265 0 kegg kegg NA NA no no no no no no Graft-versus-host disease RNA degradation -0.494782609 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease RNA polymerase -0.453043478 -0.570158103 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Ruminococcus 0 0 0.412612613 acetate-producing kegg Genus NA 0.335 no no no no no no Graft-versus-host disease Salmonella infection 0 0.706521739 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Selenocompound metabolism -0.545217391 -0.531620553 -0.474388674 kegg kegg NA NA no no no no no no Graft-versus-host disease Sphingolipid metabolism 0 0.445652174 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Sphingolipid signaling pathway 0 0.713438735 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Spliceosome -0.410434783 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Staphylococcus aureus infection 0.580869565 0.731225296 0 kegg kegg NA NA no no no up no no Graft-versus-host disease Steroid biosynthesis -0.587826087 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Synaptic vesicle cycle 0 0.462450593 0 kegg kegg NA NA no no no no up up Graft-versus-host disease Synthesis and degradation of ketone bodies 0 -0.589920949 -0.40978121 kegg kegg NA NA no no no no no no Graft-versus-host disease Systemic lupus erythematosus 0.414782609 0.687747036 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Taste transduction -0.649565217 -0.586956522 0 kegg kegg NA NA no no no no no up Graft-versus-host disease Taurine and hypotaurine metabolism -0.435652174 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Terpenoid backbone biosynthesis -0.676521739 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Th1 and Th2 cell differentiation 0 0.570158103 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Th17 cell differentiation 0 0.540513834 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Thermogenesis -0.439130435 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Thiamine metabolism 0 -0.592885375 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Thyroid hormone synthesis 0 -0.496047431 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Toll-like receptor signaling pathway 0 0.48715415 0.463835264 yes kegg kegg NA NA no no no no no no Graft-versus-host disease Toxoplasmosis 0 0.563241107 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Tuberculosis 0.480869565 0.698616601 0 kegg kegg NA NA no no no no no dn Graft-versus-host disease Type I diabetes mellitus 0.99826087 0.999011858 0.996911197 kegg kegg NA NA no no no no no no Graft-versus-host disease Tyrosine metabolism 0 -0.449604743 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.449604743 -0.414671815 kegg kegg NA NA no no no no no no Graft-versus-host disease Ubiquitin mediated proteolysis 0 -0.555335968 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Vasopressin-regulated water reabsorption 0 -0.425889328 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Viral carcinogenesis 0.790434783 0.916996047 0.851994852 kegg kegg NA NA no no no no no no Graft-versus-host disease Vitamin digestion and absorption -0.553913043 0 0 kegg kegg NA NA no no no no no no Graft-versus-host disease Yersinia infection 0 0.713438735 0.408236808 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" 2-Oxocarboxylic acid metabolism -0.504347826 -0.463438735 -0.557786358 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" ABC transporters 0 0.519762846 0 kegg kegg NA NA no no no no up up "Growth hormone synthesis, secretion and action" Adherens junction 0 -0.436758893 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Adipocytokine signaling pathway 0 0.43083004 0.509395109 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Adrenergic signaling in cardiomyocytes 0.448695652 0 0.436036036 kegg kegg NA NA no no no no no up "Growth hormone synthesis, secretion and action" AGE-RAGE signaling pathway in diabetic complications 0 0.414031621 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Aldosterone synthesis and secretion 0.511304348 0 0.538738739 kegg kegg NA NA no no no no up up "Growth hormone synthesis, secretion and action" alpha-Linolenic acid metabolism -0.5 0 -0.587902188 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Amino sugar and nucleotide sugar metabolism -0.526086957 0 -0.438867439 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Antigen processing and presentation -0.508695652 -0.659090909 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Apelin signaling pathway 0 -0.453557312 -0.468725869 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Apoptosis - multiple species 0 0.429841897 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Ascorbate and aldarate metabolism -0.465217391 0 -0.572972973 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Autophagy - animal 0 0.511857708 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Bacteroides 0 -0.493083004 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up "Growth hormone synthesis, secretion and action" beta-Alanine metabolism -0.56 -0.646245059 -0.663835264 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Biosynthesis of amino acids -0.452173913 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Biosynthesis of unsaturated fatty acids -0.456521739 -0.571146245 -0.586872587 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Butanoate metabolism -0.626086957 -0.596837945 -0.700900901 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" C-type lectin receptor signaling pathway 0 0 0.417245817 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Calcium signaling pathway 0.485217391 0 0.557786358 kegg kegg NA NA no no no no up up "Growth hormone synthesis, secretion and action" cAMP signaling pathway 0.524347826 0.455533597 0.763706564 yes kegg kegg NA NA no no no no up up "Growth hormone synthesis, secretion and action" Carbon metabolism -0.597391304 -0.746047431 -0.45045045 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Cholinergic synapse 0.577391304 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Citrate cycle (TCA cycle) -0.620869565 -0.713438735 -0.655855856 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Clostridium 0 -0.698900555 0 kegg Genus NA 0.925 no no no no no no "Growth hormone synthesis, secretion and action" Cortisol synthesis and secretion 0.633913043 0.638339921 0.727155727 kegg kegg NA NA no no no no no up "Growth hormone synthesis, secretion and action" Cushing syndrome 0.519130435 0.545454545 0.676962677 kegg kegg NA NA no no no no no up "Growth hormone synthesis, secretion and action" Cysteine and methionine metabolism -0.424347826 -0.615612648 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" DNA replication 0 0 -0.484427284 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Dopaminergic synapse 0.460869565 0 0.510939511 kegg kegg NA NA no no no no up no "Growth hormone synthesis, secretion and action" Dorea -0.470434783 0 0 kegg Genus NA 0.00362 no no no up no dn "Growth hormone synthesis, secretion and action" Drug metabolism - cytochrome P450 -0.55826087 -0.58201581 -0.678764479 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Drug metabolism - other enzymes -0.729565217 -0.670948617 -0.514800515 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Endocrine resistance 0.80173913 0.7756917 0.843500644 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" ErbB signaling pathway 0.702608696 0.688735178 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Fatty acid degradation 0 0 -0.571943372 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Fatty acid elongation -0.633913043 -0.752964427 -0.704761905 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Fatty acid metabolism 0 0 -0.544401544 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Fc epsilon RI signaling pathway 0.589565217 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Ferroptosis 0 0.428853755 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Focal adhesion 0 -0.583003953 0 kegg kegg NA NA no no no no up up "Growth hormone synthesis, secretion and action" FoxO signaling pathway 0 0.530632411 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Fructose and mannose metabolism 0 0.5256917 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Gap junction 0 0.694664032 0.508622909 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Glutamatergic synapse 0.517391304 0.710474308 0.523294723 kegg kegg NA NA no no no no up up "Growth hormone synthesis, secretion and action" Glycerolipid metabolism 0 0.56916996 0 kegg kegg NA NA no no no no no up "Growth hormone synthesis, secretion and action" Glycerophospholipid metabolism 0 0.598814229 0 kegg kegg NA NA no no no no no up "Growth hormone synthesis, secretion and action" "Glycine, serine and threonine metabolism" 0 0 0.416731017 kegg kegg NA NA no no no no up no "Growth hormone synthesis, secretion and action" Glycolysis / Gluconeogenesis -0.59826087 -0.813241107 -0.508365508 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.678853755 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.503478261 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" GnRH secretion 0.753913043 0.759881423 0 kegg kegg NA NA no no no no up up "Growth hormone synthesis, secretion and action" GnRH signaling pathway 0.619130435 0.605731225 0.628571429 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Hedgehog signaling pathway 0.508695652 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Hematopoietic cell lineage 0 -0.678853755 -0.41956242 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" HIF-1 signaling pathway 0 -0.535573123 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Hippo signaling pathway 0 -0.45256917 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Histidine metabolism -0.422608696 0 -0.503217503 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Inflammatory mediator regulation of TRP channels 0.446956522 0 0.511454311 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Inositol phosphate metabolism 0 0.500988142 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Insulin resistance 0 0.567193676 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Insulin secretion 0.611304348 0.561264822 0.733075933 yes kegg kegg NA NA no no no no up up "Growth hormone synthesis, secretion and action" Insulin signaling pathway 0 -0.458498024 -0.462805663 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" JAK-STAT signaling pathway 0 0.592885375 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Leukocyte transendothelial migration 0 -0.497035573 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Linoleic acid metabolism -0.62 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Long-term depression 0.555652174 0.639328063 0.735392535 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Long-term potentiation 0 -0.609683794 0 kegg kegg NA NA no no no no no up "Growth hormone synthesis, secretion and action" Longevity regulating pathway 0.614782609 0.532608696 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Longevity regulating pathway - multiple species 0 -0.56027668 -0.407722008 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Melanogenesis 0 0 0.493951094 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Metabolism of xenobiotics by cytochrome P450 -0.6 -0.650197628 -0.697554698 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Mismatch repair -0.535652174 -0.415019763 -0.553153153 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Mucin type O-glycan biosynthesis -0.41826087 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Necroptosis 0.424347826 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Neuroactive ligand-receptor interaction -0.544347826 0 0 kegg kegg NA NA no no no up up up "Growth hormone synthesis, secretion and action" NF-kappa B signaling pathway 0 0.469367589 0.50965251 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Non-homologous end-joining -0.543478261 -0.731225296 -0.500643501 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Notch signaling pathway 0 0.708498024 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Nucleotide excision repair 0 0 -0.447361647 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Odoribacter 0 -0.569095356 0 butyrate-producing kegg Genus NA 0.798 no no no no no no "Growth hormone synthesis, secretion and action" Oocyte meiosis 0 -0.729249012 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Other types of O-glycan biosynthesis 0 0.532608696 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Ovarian steroidogenesis 0 0.572134387 0.564736165 kegg kegg NA NA no no no no up up "Growth hormone synthesis, secretion and action" p53 signaling pathway 0 0.555335968 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Paraprevotella -0.595152643 0 0 kegg Genus NA 0.118 no no no no no no "Growth hormone synthesis, secretion and action" "Parathyroid hormone synthesis, secretion and action" 0 0 0.447104247 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Pentose and glucuronate interconversions -0.675652174 -0.548418972 -0.557528958 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Phenylalanine metabolism -0.470434783 -0.549407115 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Phosphatidylinositol signaling system 0.450434783 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Phospholipase D signaling pathway 0.522608696 0.749011858 0.720720721 kegg kegg NA NA no no no no up up "Growth hormone synthesis, secretion and action" Phototransduction 0 -0.769762846 -0.448133848 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Platinum drug resistance 0 0.431818182 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Prevotella -0.411589322 0 0 kegg Genus NA 0.367 no no no no no no "Growth hormone synthesis, secretion and action" Prevotella 0 0.632678199 0.467781804 acetate-producing kegg Genus NA 0.287 no no no no no no "Growth hormone synthesis, secretion and action" Primary bile acid biosynthesis -0.564347826 -0.745059289 -0.477220077 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Prolactin signaling pathway 0.720869565 0.497035573 0.526383526 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Propanoate metabolism -0.49826087 -0.641304348 -0.433204633 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Proteasome 0 -0.824110672 -0.604375804 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Protein export 0 -0.552371542 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Pyrimidine metabolism -0.463478261 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Pyruvate metabolism -0.47826087 -0.563241107 -0.420849421 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Regulation of actin cytoskeleton -0.549565217 -0.727272727 -0.507078507 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Regulation of lipolysis in adipocytes 0.571304348 0.614624506 0.623166023 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Relaxin signaling pathway 0.564347826 0.613636364 0.748519949 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Renin-angiotensin system -0.413913043 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Retinol metabolism -0.506956522 0 -0.641184041 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" RIG-I-like receptor signaling pathway 0 0 0.517374517 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" RNA polymerase 0 0 -0.452767053 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" RNA transport 0 -0.451581028 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Serotonergic synapse 0 0.503952569 0.538481338 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Signaling pathways regulating pluripotency of stem cells 0.612173913 0.572134387 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Sphingolipid signaling pathway 0.473043478 0 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Steroid biosynthesis 0 -0.420948617 -0.490604891 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Steroid hormone biosynthesis -0.631304348 0 -0.462290862 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Sulfur metabolism 0 -0.429841897 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Synthesis and degradation of ketone bodies 0 0 -0.445045045 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Taurine and hypotaurine metabolism 0.448695652 0.792490119 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" TGF-beta signaling pathway 0 -0.514822134 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Thiamine metabolism -0.439130435 -0.504940711 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Thyroid hormone synthesis 0 0 0.431145431 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Tight junction 0 -0.627470356 -0.432947233 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" TNF signaling pathway 0.488695652 0.45256917 0.497297297 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Toll-like receptor signaling pathway 0.406956522 0 0 yes kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Tryptophan metabolism -0.640869565 -0.713438735 -0.684684685 kegg kegg NA NA no no no no up no "Growth hormone synthesis, secretion and action" Type II diabetes mellitus 0.617391304 0.697628458 0 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Tyrosine metabolism -0.450434783 0 -0.575804376 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" Ubiquinone and other terpenoid-quinone biosynthesis -0.567826087 0 -0.467953668 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" "Valine, leucine and isoleucine degradation" -0.582608696 -0.480237154 -0.722265122 kegg kegg NA NA no no no no no no "Growth hormone synthesis, secretion and action" VEGF signaling pathway 0.593043478 0.47826087 0 kegg kegg NA NA no no no no no no GUDCA+blood 11-HETE+blood 0 0.493276281 0 serum_bileacids serum_ARA 0.0766 0.464 no no dn no no no GUDCA+blood 12-ketoDCA+stool 0 0 -0.461654135 serum_bileacids stool_bileacids 0.0766 0.505 no no dn no no no GUDCA+blood 16:0/16:0-PC+blood -0.694736842 0 0 serum_bileacids serum_phospholipids 0.0766 0.00079 no no dn no up up GUDCA+blood 16:0/16:1-PC+blood 0 0.507352941 0 serum_bileacids serum_phospholipids 0.0766 0.00283 no no dn up up no GUDCA+blood 16:0/16:1-PI+blood 0.47518797 0 0 serum_bileacids serum_phospholipids 0.0766 0.262 no no dn no no no GUDCA+blood 16:0/18:0-PC+blood 0 0 -0.431794872 serum_bileacids serum_phospholipids 0.0766 0.521 no no dn no no no GUDCA+blood 16:0/18:1-PC+blood -0.476691729 0 0 serum_bileacids serum_phospholipids 0.0766 6.15E-07 no no dn up up up GUDCA+blood 16:0/18:2-PC+blood -0.457142857 0 0 serum_bileacids serum_phospholipids 0.0766 3.24E-06 no no dn no up up GUDCA+blood 16:0/22:6-PC+blood -0.536842105 0 0 serum_bileacids serum_phospholipids 0.0766 4.53E-05 no no dn no up up GUDCA+blood 16:1/16:0-PC+blood -0.511278195 0 0 serum_bileacids serum_phospholipids 0.0766 0.0215 no no dn no up up GUDCA+blood 16:1/16:1-PC+blood -0.598496241 0 0 serum_bileacids serum_phospholipids 0.0766 0.0177 no no dn no no up GUDCA+blood 16:1/18:2-PG+blood -0.545864662 0 0 serum_bileacids serum_phospholipids 0.0766 1.40E-08 no no dn no up up GUDCA+blood 18:0/16:0-PC+blood -0.494736842 0 0 serum_bileacids serum_phospholipids 0.0766 9.64E-07 no no dn up up up GUDCA+blood 18:0/18:0-PC+blood 0 0.512254902 0 serum_bileacids serum_phospholipids 0.0766 0.426 no no dn no no no GUDCA+blood 18:0/18:0-PE+blood 0 0 -0.482393162 serum_bileacids serum_phospholipids 0.0766 0.00896 no no dn up up no GUDCA+blood 18:0/18:1-PC+blood 0 0.56127451 0 serum_bileacids serum_phospholipids 0.0766 0.393 no no dn no no no GUDCA+blood 18:0/18:1-PE+blood 0 0 -0.411965812 serum_bileacids serum_phospholipids 0.0766 0.00716 no no dn up up no GUDCA+blood 18:0/18:2-PC+blood -0.556390977 0 0 serum_bileacids serum_phospholipids 0.0766 1.74E-06 no no dn no up up GUDCA+blood 18:0/20:4-PC+blood -0.44962406 0 0 serum_bileacids serum_phospholipids 0.0766 0.454 no no dn no no no GUDCA+blood 18:1/16:0-PC+blood -0.520300752 0 0 serum_bileacids serum_phospholipids 0.0766 2.43E-05 no no dn no up up GUDCA+blood 18:1/18:0-PC+blood -0.630075188 0 0 serum_bileacids serum_phospholipids 0.0766 1.83E-06 no no dn no up up GUDCA+blood 18:1/18:0-PS+blood -0.610526316 0 0 serum_bileacids serum_phospholipids 0.0766 0.193 no no dn no no no GUDCA+blood 18:1/18:2-PG+blood -0.520300752 0 0 serum_bileacids serum_phospholipids 0.0766 5.58E-07 no no dn no up up GUDCA+blood 18:1/20:4-PI+blood 0 -0.632352941 0 serum_bileacids serum_phospholipids 0.0766 0.192 no no dn no no no GUDCA+blood 18:2/16:0-PC+blood -0.618045113 0 0 serum_bileacids serum_phospholipids 0.0766 8.67E-05 no no dn no up up GUDCA+blood 18:3n3+blood -0.493233083 0 0 serum_bileacids serum_fattyacid 0.0766 0.291 no no dn no no no GUDCA+blood 20:0-LPC+blood 0.506766917 0 0 serum_bileacids serum_phospholipids 0.0766 0.199 no no dn no no no GUDCA+blood 20:0/20:5-PC+blood -0.446616541 0 0 serum_bileacids serum_phospholipids 0.0766 0.882 no no dn no no no GUDCA+blood 20:3/18:0-PC+blood -0.49924812 0 0 serum_bileacids serum_phospholipids 0.0766 0.296 no no dn no no no GUDCA+blood 20:4-LPA+blood -0.563909774 0 0 serum_bileacids serum_phospholipids 0.0766 0.398 no no dn no no no GUDCA+blood 20:5/18:0-PC+blood -0.446616541 0 0 serum_bileacids serum_phospholipids 0.0766 3.97E-06 no no dn no up up GUDCA+blood AA+blood -0.673684211 0 0 serum_bileacids serum_ARA 0.0766 0.212 no no dn no no no GUDCA+blood AGE-RAGE signaling pathway in diabetic complications 0 -0.564705882 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Alistipes 0 0 -0.42024261 serum_bileacids Genus 0.0766 0.0114 no no dn no up no GUDCA+blood Allograft rejection 0 -0.529411765 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Alzheimer disease 0 0.6 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Amphetamine addiction 0 0.591176471 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Amyotrophic lateral sclerosis 0 0.697058824 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Apoptosis 0 -0.502941176 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Arginine and proline metabolism 0 -0.514705882 0 serum_bileacids kegg 0.0766 NA no no dn no up no GUDCA+blood Autoimmune thyroid disease 0 -0.529411765 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Biosynthesis of amino acids 0 -0.570588235 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Biosynthesis of cofactors 0 0.514705882 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Bladder cancer 0 -0.508823529 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Blautia 0 0 0.539625817 acetate-producing serum_bileacids Genus 0.0766 1.36E-05 no no dn up dn dn GUDCA+blood CA+blood 0 0.500306654 0 serum_bileacids serum_bileacids 0.0766 0.606 no no dn no no no GUDCA+blood Cardiac muscle contraction 0 0.526470588 0 serum_bileacids kegg 0.0766 NA no no dn no no up GUDCA+blood CDCA+blood 0.481203008 0.754901961 0 serum_bileacids serum_bileacids 0.0766 0.506 no no dn no no no GUDCA+blood Cell adhesion molecules 0 -0.532352941 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Cellular senescence 0 -0.608823529 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood cGMP-PKG signaling pathway 0 -0.6 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood d18:1-18:0-SM+blood -0.598496241 0 0 serum_bileacids serum_phospholipids 0.0766 0.97 no no dn no no no GUDCA+blood d18:1-18:1-SM+blood -0.535338346 0 0 serum_bileacids serum_phospholipids 0.0766 0.916 no no dn no no no GUDCA+blood d18:1-20:1-SM+blood -0.470676692 -0.5 0 serum_bileacids serum_phospholipids 0.0766 0.0992 no no dn no no no GUDCA+blood DCA+blood 0.6 0 0 serum_bileacids serum_bileacids 0.0766 0.122 no no dn no no no GUDCA+blood Diabetic cardiomyopathy 0 0.570588235 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Endocytosis 0 -0.564705882 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Epithelial cell signaling in Helicobacter pylori infection 0 -0.582352941 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Fc epsilon RI signaling pathway 0 -0.658823529 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Fc gamma R-mediated phagocytosis 0 -0.65 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Fusobacterium 0 -0.539815486 0.408765371 serum_bileacids Genus 0.0766 0.628 no no dn no no no GUDCA+blood GABAergic synapse 0 -0.558823529 0 serum_bileacids kegg 0.0766 NA no no dn no up up GUDCA+blood GCA+blood 0.789473684 0 0.413333333 yes serum_bileacids serum_bileacids 0.0766 0.16 no no dn no no no GUDCA+blood GCDCA+blood 0.840601504 0.772058824 0.701196581 serum_bileacids serum_bileacids 0.0766 0.31 no no dn no no no GUDCA+blood GPC+blood 0 0 -0.494700855 serum_bileacids serum_choline 0.0766 0.00427 no no dn no up up GUDCA+blood Graft-versus-host disease 0 -0.529411765 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood HCA+stool 0 0 0.521804511 serum_bileacids stool_bileacids 0.0766 0.155 no no dn no no no GUDCA+blood Hepatitis B 0 -0.505882353 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Hepatitis C 0 0 -0.509230769 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Human papillomavirus infection 0 -0.594117647 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Huntington disease 0 0.605882353 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood IL-17 signaling pathway 0 -0.517647059 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood iso-LCA+stool 0 0 -0.446616541 serum_bileacids stool_bileacids 0.0766 0.72 no no dn no no no GUDCA+blood Lipid and atherosclerosis 0 -0.626470588 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood mRNA surveillance pathway 0 0.541176471 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Natural killer cell mediated cytotoxicity 0 -0.617647059 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Neutrophil extracellular trap formation 0 -0.576470588 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Nicotinate and nicotinamide metabolism 0 -0.635294118 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood NOD-like receptor signaling pathway 0 -0.570588235 -0.416153846 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Non-alcoholic fatty liver disease 0 0.529411765 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood nutriCA+stool 0 0 0.637593985 serum_bileacids stool_bileacids 0.0766 0.481 no no dn no no no GUDCA+blood Olfactory transduction 0 -0.602941176 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Osteoclast differentiation 0 -0.614705882 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Oxidative phosphorylation 0 0.588235294 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Parkinson disease 0 0.558823529 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Pathogenic Escherichia coli infection 0 -0.552941176 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Pathways of neurodegeneration - multiple diseases 0 0.594117647 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Pertussis 0 -0.538235294 0 serum_bileacids kegg 0.0766 NA no no dn no no dn GUDCA+blood Phagosome 0 -0.591176471 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Phenylacetic acid+stool 0 -0.618181818 0 serum_bileacids stool_cometabolism 0.0766 0.785 no no dn no no no GUDCA+blood Phospholipase D signaling pathway 0 -0.555882353 0 serum_bileacids kegg 0.0766 NA no no dn no up up GUDCA+blood Porphyrin and chlorophyll metabolism 0 0.535294118 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood PPAR signaling pathway 0 -0.535294118 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Prion disease 0 0.605882353 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Progesterone-mediated oocyte maturation -0.475438596 0 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Prolactin signaling pathway 0 -0.597058824 -0.425384615 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Protein processing in endoplasmic reticulum 0 0.629411765 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Purine metabolism 0 0.55 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Retrograde endocannabinoid signaling 0 0.552941176 0.420769231 serum_bileacids kegg 0.0766 NA no no dn no no up GUDCA+blood RIG-I-like receptor signaling pathway 0 0 -0.423076923 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood RNA degradation 0 0.570588235 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Roseburia 0 0.519926523 0 butyrate-producing serum_bileacids Genus 0.0766 0.495 no no dn no no no GUDCA+blood Sphingolipid signaling pathway 0 -0.520588235 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Systemic lupus erythematosus 0 -0.523529412 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Thermogenesis 0 0.555882353 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Tuberculosis 0 -0.511764706 0 serum_bileacids kegg 0.0766 NA no no dn no no dn GUDCA+blood Type I diabetes mellitus 0 -0.529411765 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Ubiquitin mediated proteolysis 0 0.570588235 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood UDCA+stool 0 0 0.616541353 serum_bileacids stool_bileacids 0.0766 0.266 no no dn no no no GUDCA+blood Viral carcinogenesis 0 -0.585294118 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Wnt signaling pathway 0 0.514705882 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+blood Yersinia infection 0 -0.541176471 0 serum_bileacids kegg 0.0766 NA no no dn no no no GUDCA+stool 3-(3-Hydroxyphenyl)propanoic acid+stool 0 -0.615834573 0 yes stool_bileacids stool_cometabolism 0.0085 0.33 no dn no no no no GUDCA+stool B cell receptor signaling pathway 0 0.674126972 0 yes stool_bileacids kegg 0.0085 NA no dn no no no no GUDCA+stool C-type lectin receptor signaling pathway 0 0.649342892 0 yes stool_bileacids kegg 0.0085 NA no dn no no no no GUDCA+stool Insulin resistance 0 0.609688364 0 yes stool_bileacids kegg 0.0085 NA no dn no no no no GUDCA+stool Neurotrophin signaling pathway 0 0.684040604 0 yes stool_bileacids kegg 0.0085 NA no dn no no no no GUDCA+stool TNF signaling pathway 0 0.609688364 0 yes stool_bileacids kegg 0.0085 NA no dn no no no no GUDCA+stool Toll-like receptor signaling pathway 0 0.604731548 0 yes yes stool_bileacids kegg 0.0085 NA no dn no no no no HCA+blood 12-ketoDCA+blood 0.48284992 0 0 serum_bileacids serum_bileacids 0.544 0.517 no no no no no no HCA+blood 14:0/16:0-PC+blood 0 0.486027821 0 serum_bileacids serum_phospholipids 0.544 0.0358 no no no no up no HCA+blood 16:0/20:5-PG+blood -0.521189187 0 0 serum_bileacids serum_phospholipids 0.544 0.00656 no no no no up no HCA+blood 16:0/22:6-PC+blood -0.556239922 0 0 serum_bileacids serum_phospholipids 0.544 4.53E-05 no no no no up up HCA+blood 16:1/16:0-PC+blood -0.556239922 0 0 serum_bileacids serum_phospholipids 0.544 0.0215 no no no no up up HCA+blood 16:1/16:1-PC+blood -0.656820291 0 0 serum_bileacids serum_phospholipids 0.544 0.0177 no no no no no up HCA+blood 16:1/18:1-PG+blood -0.533380747 0 0 serum_bileacids serum_phospholipids 0.544 3.21E-05 no no no no up up HCA+blood 16:1/18:2-PG+blood -0.489186342 0 0 serum_bileacids serum_phospholipids 0.544 1.40E-08 no no no no up up HCA+blood 18:0/16:0-PC+blood -0.46708914 0 0 serum_bileacids serum_phospholipids 0.544 9.64E-07 no no no up up up HCA+blood 18:0/18:0-PS+blood -0.448039828 0 0 serum_bileacids serum_phospholipids 0.544 0.00617 no no no no up no HCA+blood 18:0/18:1-PC+blood -0.467851112 0 0 serum_bileacids serum_phospholipids 0.544 0.393 no no no no no no HCA+blood 18:0/20:3-PI+blood -0.526522995 0 0 serum_bileacids serum_phospholipids 0.544 0.377 no no no no no no HCA+blood 18:0/20:4-PI+blood -0.563859647 0 0 serum_bileacids serum_phospholipids 0.544 0.167 no no no no no no HCA+blood 18:0/22:6-PA+blood -0.637770979 0 0 serum_bileacids serum_phospholipids 0.544 0.22 no no no no no no HCA+blood 18:1-LPE+blood 0.569955427 0 0 serum_bileacids serum_phospholipids 0.544 0.117 no no no no no no HCA+blood 18:1/18:0-PS+blood -0.695680889 0 0 serum_bileacids serum_phospholipids 0.544 0.193 no no no no no no HCA+blood 18:1/18:1-PG+blood -0.583670932 0 0 serum_bileacids serum_phospholipids 0.544 0.00352 no no no no up up HCA+blood 18:1/18:2-PG+blood -0.481566617 0 0 serum_bileacids serum_phospholipids 0.544 5.58E-07 no no no no up up HCA+blood 18:1/20:4-PC+blood -0.539476527 0 0 serum_bileacids serum_phospholipids 0.544 0.582 no no no no no no HCA+blood 18:1+blood -0.484614507 0 -0.525137052 yes serum_bileacids serum_fattyacid 0.544 0.00202 no no no up no dn HCA+blood 18:2-LPE+blood 0.499091985 0 0 serum_bileacids serum_phospholipids 0.544 0.112 no no no no no no HCA+blood 18:2/18:2-PC+blood 0 0.486027821 0 serum_bileacids serum_phospholipids 0.544 1.98E-05 no no no dn up up HCA+blood 18:2/20:4-PC+blood -0.468613085 0 0 serum_bileacids serum_phospholipids 0.544 0.0145 no no no no no up HCA+blood 18:2n6c+blood 0 0 -0.447392293 serum_bileacids serum_fattyacid 0.544 0.15 no no no no no no HCA+blood 18:3-LPC+blood 0.534904692 0 0 serum_bileacids serum_phospholipids 0.544 0.147 no no no no no no HCA+blood 18:3n3+blood -0.48232859 0 0 serum_bileacids serum_fattyacid 0.544 0.291 no no no no no no HCA+blood 18:3n6+blood 0 0.578723848 0 serum_bileacids serum_fattyacid 0.544 0.0463 no no no up no dn HCA+blood 20:0/20:5-PC+blood -0.829788048 0 0 serum_bileacids serum_phospholipids 0.544 0.882 no no no no no no HCA+blood 20:1-LPA+blood 0 -0.514838748 0 serum_bileacids serum_phospholipids 0.544 0.0187 no no no dn dn no HCA+blood 20:1/20:4-PE+blood -0.45489758 0 0 serum_bileacids serum_phospholipids 0.544 0.0042 no no no up up no HCA+blood 20:2+blood 0 0 -0.523697334 serum_bileacids serum_fattyacid 0.544 0.478 no no no no no no HCA+blood 20:3/18:0-PC+blood -0.579861069 0 0 serum_bileacids serum_phospholipids 0.544 0.296 no no no no no no HCA+blood 20:3/18:0-PI+blood -0.535666665 0 0 serum_bileacids serum_phospholipids 0.544 0.289 no no no no no no HCA+blood 20:4-LPA+blood 0 -0.65388279 0 serum_bileacids serum_phospholipids 0.544 0.398 no no no no no no HCA+blood 20:4/16:0-PE+blood 0 0.497301662 0 serum_bileacids serum_phospholipids 0.544 0.00529 no no no no up up HCA+blood 20:5/18:0-PC+blood -0.575289234 0 0 serum_bileacids serum_phospholipids 0.544 3.97E-06 no no no no up up HCA+blood 22:0/16:0-PE+blood -0.508235655 0 0 serum_bileacids serum_phospholipids 0.544 0.091 no no no no no up HCA+blood 22:1-LPA+blood 0 -0.518596695 0 serum_bileacids serum_phospholipids 0.544 0.00373 no no no no up up HCA+blood acetic acid C2+blood -0.489186342 0 0 serum_bileacids serum_scfa 0.544 0.000193 no no no up dn no HCA+blood Adrenergic signaling in cardiomyocytes 0 0.533016179 0.418291471 serum_bileacids kegg 0.544 NA no no no no no up HCA+blood AGE-RAGE signaling pathway in diabetic complications 0 -0.501307001 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Akkermansia -0.459178196 0 0 acetate-producing serum_bileacids Genus 0.544 0.23 no no no no no no HCA+blood Aldosterone synthesis and secretion 0 0.599454456 0.451722173 serum_bileacids kegg 0.544 NA no no no no up up HCA+blood Allograft rejection 0 -0.542075944 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Alzheimer disease 0 0.533016179 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Amphetamine addiction 0 0.679482381 0.430522216 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood AMPK signaling pathway 0 0.608514221 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Amyotrophic lateral sclerosis 0 0.585864809 0.443976035 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Apelin signaling pathway 0 0.522446453 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Arginine and proline metabolism 0 -0.533016179 0 serum_bileacids kegg 0.544 NA no no no no up no HCA+blood Autoimmune thyroid disease 0 -0.542075944 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Biosynthesis of amino acids 0 -0.603984339 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Biosynthesis of cofactors 0.541713944 0 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Bladder cancer 0 -0.511876727 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood CA+blood 0.921571268 0.810960982 0.732806451 serum_bileacids serum_bileacids 0.544 0.606 no no no no no no HCA+blood capric acid C6+blood 0 -0.532375834 0 serum_bileacids serum_scfa 0.544 0.433 no no no no no no HCA+blood CDCA+blood 0.840455663 0.62757716 0.716619513 serum_bileacids serum_bileacids 0.544 0.506 no no no no no no HCA+blood CDCA+stool 0 0 0.482428456 serum_bileacids stool_bileacids 0.544 0.663 no no no no no no HCA+blood Cell adhesion molecules 0 -0.536036101 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Cell cycle 0 0.58888473 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Cellular senescence 0 -0.507346845 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood cGMP-PKG signaling pathway 0 -0.671932577 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Chemokine signaling pathway 0 -0.602474378 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Colorectal cancer 0 0.582844887 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Coprococcus 0 0 -0.412119208 butyrate-producing serum_bileacids Genus 0.544 0.612 no no no no no no HCA+blood Coronavirus disease - COVID-19 0 0.514896649 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Cushing syndrome 0 0.62361383 0 serum_bileacids kegg 0.544 NA no no no no no up HCA+blood Cysteine+blood 0 -0.57621855 -0.443433069 yes serum_bileacids serum_aminoacids 0.544 1.81E-07 no no no dn up up HCA+blood Cytokine-cytokine receptor interaction 0 -0.619083947 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood d18:1-18:0-SM+blood -0.514331435 0 0 serum_bileacids serum_phospholipids 0.544 0.97 no no no no no no HCA+blood d18:1-18:1-SM+blood -0.504425792 0 0 serum_bileacids serum_phospholipids 0.544 0.916 no no no no no no HCA+blood Diabetic cardiomyopathy 0 0.517916571 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Dopaminergic synapse 0 0 0.455799088 serum_bileacids kegg 0.544 NA no no no no up no HCA+blood EGFR tyrosine kinase inhibitor resistance 0 0.569255239 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Endocytosis 0 -0.540565983 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Epithelial cell signaling in Helicobacter pylori infection 0 -0.569255239 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Fc epsilon RI signaling pathway 0 -0.529996257 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Fc gamma R-mediated phagocytosis -0.483800447 -0.711191559 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood GCA+blood 0 0.52485994 0 yes serum_bileacids serum_bileacids 0.544 0.16 no no no no no no HCA+blood GCDCA+blood 0.502901847 0.547407623 0 serum_bileacids serum_bileacids 0.544 0.31 no no no no no no HCA+blood Glucagon signaling pathway 0 0.664382773 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood "Glycine, serine and threonine metabolism" 0.492710215 0 0 serum_bileacids kegg 0.544 NA no no no no up no HCA+blood Graft-versus-host disease 0 -0.542075944 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood GUDCA+blood 0 0.663903982 0 serum_bileacids serum_bileacids 0.544 0.0766 no no no no no dn HCA+blood Huntington disease 0 0.533016179 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood IL-17 signaling pathway 0 -0.599454456 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Inflammatory mediator regulation of TRP channels 0 0.597944496 0.410953024 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Influenza A 0 -0.560195474 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Insulin signaling pathway 0 0.585864809 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Lipid and atherosclerosis 0 -0.738370854 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Lysosome 0 -0.67797242 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Mitophagy - animal 0.517657568 0 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood mRNA surveillance pathway 0 0.724781207 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood mTOR signaling pathway 0 0.591904652 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Natural killer cell mediated cytotoxicity 0 -0.502816962 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Neuroactive ligand-receptor interaction 0 -0.608514221 0 serum_bileacids kegg 0.544 NA no no no up up up HCA+blood Neutrophil extracellular trap formation 0 -0.67797242 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Nicotinate and nicotinamide metabolism 0 -0.507346845 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Non-alcoholic fatty liver disease 0 0.51640661 0.41258379 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood nutriCA+stool 0 0 0.586481652 serum_bileacids stool_bileacids 0.544 0.481 no no no no no no HCA+blood Olfactory transduction 0 -0.729311089 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Osteoclast differentiation 0 -0.51640661 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood "Parathyroid hormone synthesis, secretion and action" 0 0.508856806 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Pathogenic Escherichia coli infection 0 -0.724781207 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Pathways of neurodegeneration - multiple diseases 0 0.520936492 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Peroxisome 0 -0.522446453 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Pertussis -0.465980909 -0.673442538 0 serum_bileacids kegg 0.544 NA no no no no no dn HCA+blood Phagosome 0 -0.650793125 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Phosphatidylinositol signaling system 0 0.51640661 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood PI3K-Akt signaling pathway 0 0.504326923 0 yes serum_bileacids kegg 0.544 NA no no no no up up HCA+blood Prevotella 0.468717716 0 0 acetate-producing serum_bileacids Genus 0.544 0.287 no no no no no no HCA+blood Prion disease 0 0.548115788 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Protein processing in endoplasmic reticulum 0 0.619083947 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Proteoglycans in cancer 0.559533481 0 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Regulation of actin cytoskeleton 0 0 0.522660493 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Rheumatoid arthritis 0 -0.613044104 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Ribosome 0 0.514896649 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Ribosome biogenesis in eukaryotes 0 0.590394691 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood RNA degradation 0 0.596434535 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood RNA transport 0 0.537546062 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Roseburia 0 0 0.446312505 butyrate-producing serum_bileacids Genus 0.544 0.495 no no no no no no HCA+blood Salmonella infection 0 -0.597944496 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Spinocerebellar ataxia 0 0.661362851 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Staphylococcus aureus infection 0 -0.687032185 0 serum_bileacids kegg 0.544 NA no no no up no no HCA+blood Systemic lupus erythematosus -0.494492169 -0.674952499 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Thermogenesis 0 0.561705435 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Tuberculosis -0.479345562 -0.653813047 0 serum_bileacids kegg 0.544 NA no no no no no dn HCA+blood Type I diabetes mellitus 0 -0.542075944 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Ubiquitin mediated proteolysis 0.518548545 0 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Viral myocarditis 0 -0.49979704 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Viral protein interaction with cytokine and cytokine receptor 0 -0.522446453 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Wnt signaling pathway 0 0.539056022 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+blood Yersinia infection 0 -0.764040189 0 serum_bileacids kegg 0.544 NA no no no no no no HCA+stool 4-hydroxybenzoic acid+stool 0.486068111 0 0 stool_bileacids stool_cometabolism 0.155 0.0536 no no no no dn no HCA+stool Amyotrophic lateral sclerosis 0 0 0.518915867 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Antigen processing and presentation 0.605779154 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool CA+stool 0.568627451 0 0.419960474 stool_bileacids stool_bileacids 0.155 0.827 no no no no no no HCA+stool Cardiac muscle contraction 0 0 0.43308865 stool_bileacids kegg 0.155 NA no no no no no up HCA+stool CDCA+stool 0.655314757 0 0 stool_bileacids stool_bileacids 0.155 0.663 no no no no no no HCA+stool Chemical carcinogenesis - receptor activation -0.492260062 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Coronavirus disease - COVID-19 -0.477812178 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Cushing syndrome -0.682146543 0 0 stool_bileacids kegg 0.155 NA no no no no no up HCA+stool Endocrine resistance -0.589267286 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Epstein-Barr virus infection 0.552115583 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Fc gamma R-mediated phagocytosis 0.653250774 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool GABAergic synapse 0.581011352 0 0 stool_bileacids kegg 0.155 NA no no no no up up HCA+stool "Growth hormone synthesis, secretion and action" -0.506707946 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Herpes simplex virus 1 infection 0.512899897 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Human immunodeficiency virus 1 infection 0.492260062 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Human T-cell leukemia virus 1 infection 0.545923633 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Huntington disease 0 0 0.498588368 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool IL-17 signaling pathway 0.55624355 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Lipid and atherosclerosis 0.678018576 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Long-term depression -0.492260062 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Lysosome 0.539731682 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Neutrophil extracellular trap formation 0.539731682 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool NOD-like receptor signaling pathway 0.521155831 0 -0.429700734 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Non-alcoholic fatty liver disease 0 0 0.450028233 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Olfactory transduction 0.605779154 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Oscillospira -0.665634675 0 0 LPS-producing stool_bileacids Genus 0.155 0.62 no no no no no no HCA+stool Osteoclast differentiation 0.506707946 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Peroxisome 0.607843137 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Pertussis 0.729618163 0 0 stool_bileacids kegg 0.155 NA no no no no no dn HCA+stool Proteasome 0.481940144 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Ribosome -0.484004128 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Salmonella infection 0.622291022 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Systemic lupus erythematosus 0.568627451 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Thyroid hormone signaling pathway -0.475748194 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Transcriptional misregulation in cancer 0.488132095 0 0 stool_bileacids kegg 0.155 NA no no no no no no HCA+stool Tuberculosis 0.517027864 0 0 stool_bileacids kegg 0.155 NA no no no no no dn HDCA+blood 11-HETE+blood 0 -0.668320777 0 serum_bileacids serum_ARA 0.483 0.464 no no no no no no HDCA+blood 12-ketoDCA+blood 0 0.893684825 0 serum_bileacids serum_bileacids 0.483 0.517 no no no no no no HDCA+blood "12,13-EPOME+blood" 0 -0.531092282 0.421929486 serum_bileacids serum_ARA 0.483 0.901 no no no no no no HDCA+blood 14:0/16:0-PC+blood 0 0 -0.48342045 serum_bileacids serum_phospholipids 0.483 0.0358 no no no no up no HDCA+blood 14:0/18:0-PC+blood 0 0 -0.46354705 serum_bileacids serum_phospholipids 0.483 0.00289 no no no up up no HDCA+blood 16:0-LPE+blood 0 0 -0.50925587 serum_bileacids serum_phospholipids 0.483 0.0711 no no no up up no HDCA+blood 16:0/16:1-PC+blood 0 -0.490098029 -0.45957237 serum_bileacids serum_phospholipids 0.483 0.00283 no no no up up no HDCA+blood 16:0/18:0-PS+blood 0 -0.515892663 0 serum_bileacids serum_phospholipids 0.483 0.377 no no no no no no HDCA+blood 16:0/18:1-PC+blood 0 0 -0.44764833 serum_bileacids serum_phospholipids 0.483 6.15E-07 no no no up up up HDCA+blood 16:0/18:1-PE+blood 0 -0.65039325 0 serum_bileacids serum_phospholipids 0.483 0.000107 no no no up up no HDCA+blood 16:0/18:3-PC+blood 0 0 -0.440692641 serum_bileacids serum_phospholipids 0.483 0.00216 no no no no up up HDCA+blood 16:0/20:3-PC+blood 0 0 -0.628496269 serum_bileacids serum_phospholipids 0.483 5.43E-06 no no no no up up HDCA+blood 16:0/20:4-PE+blood 0 -0.584064193 0 serum_bileacids serum_phospholipids 0.483 0.00139 no no no up up no HDCA+blood 16:0/22:6-PE+blood 0 -0.543529769 0 serum_bileacids serum_phospholipids 0.483 0.000934 no no no up up no HDCA+blood 18:0-LPE+blood 0 0 -0.416844561 serum_bileacids serum_phospholipids 0.483 0.491 no no no no no no HDCA+blood 18:0/16:0-PC+blood 0 0 -0.44367365 serum_bileacids serum_phospholipids 0.483 9.64E-07 no no no up up up HDCA+blood 18:0/18:0-PE+blood -0.487794926 -0.598803983 0 serum_bileacids serum_phospholipids 0.483 0.00896 no no no up up no HDCA+blood 18:0/18:0-PS+blood 0 -0.550899665 0 serum_bileacids serum_phospholipids 0.483 0.00617 no no no no up no HDCA+blood 18:0/18:1-PE+blood -0.487794926 -0.584064193 0 serum_bileacids serum_phospholipids 0.483 0.00716 no no no up up no HDCA+blood 18:0/18:1-PG+blood -0.487794926 0 0 serum_bileacids serum_phospholipids 0.483 0.000842 no no no no up no HDCA+blood 18:0/18:1-PI+blood 0 -0.633810985 0 serum_bileacids serum_phospholipids 0.483 0.599 no no no no no no HDCA+blood 18:0/20:3-PC+blood 0 0 -0.598686169 serum_bileacids serum_phospholipids 0.483 0.0682 no no no no up no HDCA+blood 18:0/20:3-PI+blood 0 -0.591434088 0 serum_bileacids serum_phospholipids 0.483 0.377 no no no no no no HDCA+blood 18:0/22:6-PE+blood 0 -0.512207715 0 serum_bileacids serum_phospholipids 0.483 0.00022 no no no up up no HDCA+blood 18:1/16:0-PE+blood 0 -0.580379245 0 serum_bileacids serum_phospholipids 0.483 0.000182 no no no up up no HDCA+blood 18:1/16:1-PE+blood 0 -0.615386247 0 serum_bileacids serum_phospholipids 0.483 0.000184 no no no up up no HDCA+blood 18:1/18:0-PE+blood 0 -0.591434088 0 serum_bileacids serum_phospholipids 0.483 1.39E-06 no no no up up no HDCA+blood 18:1/18:1-PC+blood 0 0 -0.631477279 serum_bileacids serum_phospholipids 0.483 1.34E-05 no no no no up up HDCA+blood 18:1/18:1-PE+blood 0 -0.661448092 0 serum_bileacids serum_phospholipids 0.483 1.03E-05 no no no up up no HDCA+blood 18:1/18:1-PG+blood 0 -0.50483782 0 serum_bileacids serum_phospholipids 0.483 0.00352 no no no no up up HDCA+blood 18:1/18:2-PE+blood 0 -0.512207715 0 serum_bileacids serum_phospholipids 0.483 0.000293 no no no up up no HDCA+blood 18:1/20:3-PC+blood 0 0 -0.586762129 serum_bileacids serum_phospholipids 0.483 0.00872 no no no no up up HDCA+blood 18:2-LPC+blood 0.457488141 0 0 serum_bileacids serum_phospholipids 0.483 0.00743 no no no dn no up HDCA+blood 18:2/18:2-PS+blood 0 -0.633810985 0 serum_bileacids serum_phospholipids 0.483 0.00674 no no no up up no HDCA+blood 18:3/16:0-PE+blood 0 0 -0.45361035 serum_bileacids serum_phospholipids 0.483 0.00149 no no no up up no HDCA+blood 20:0/20:4-PE+blood 0 0 -0.44466732 serum_bileacids serum_phospholipids 0.483 0.00128 no no no up up no HDCA+blood 20:0+blood 0 0 -0.411876211 yes serum_bileacids serum_fattyacid 0.483 0.000278 no no no dn no up HDCA+blood 20:2-LPC+blood 0 0 -0.46553439 serum_bileacids serum_phospholipids 0.483 0.119 no no no no no up HDCA+blood 20:2-LPE+blood -0.460374502 0 0 serum_bileacids serum_phospholipids 0.483 0.177 no no no no no no HDCA+blood 20:2/18:0-PC+blood 0 0 -0.598686169 serum_bileacids serum_phospholipids 0.483 0.0427 no no no no up no HDCA+blood 20:2/18:1-PE+blood 0 -0.654078197 -0.549002669 serum_bileacids serum_phospholipids 0.483 0.00208 no no no up up no HDCA+blood 20:3-LPC+blood 0 0 -0.549002669 serum_bileacids serum_phospholipids 0.483 0.0292 no no no no up no HDCA+blood 20:3-LPE+blood 0 0 -0.47447742 serum_bileacids serum_phospholipids 0.483 0.084 no no no no up no HDCA+blood 20:3n6+blood 0 -0.521420084 -0.45957237 serum_bileacids serum_fattyacid 0.483 0.0884 no no no up no no HDCA+blood 20:4-LPC+blood 0 0.619071195 0 serum_bileacids serum_phospholipids 0.483 0.949 no no no no no no HDCA+blood 4-hydroxybenzoic acid+stool 0 0 -0.486204163 serum_bileacids stool_cometabolism 0.483 0.0536 no no no no dn no HDCA+blood AA+blood 0.493567647 0 0 serum_bileacids serum_ARA 0.483 0.212 no no no no no no HDCA+blood Adherens junction 0 0 0.405582262 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood Antigen processing and presentation 0 -0.552257939 0 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood Betaine+blood 0 0.510365241 0 serum_bileacids serum_choline 0.483 0.857 no no no no no no HDCA+blood Butyricicoccus -0.536805675 0 0 butyrate-producing serum_bileacids Genus 0.483 0.852 no no no no no no HDCA+blood Clostridium 0 -0.580381 0 serum_bileacids Genus 0.483 0.925 no no no no no no HDCA+blood Cysteine+blood 0.518101712 0 0 yes serum_bileacids serum_aminoacids 0.483 1.81E-07 no no no dn up up HDCA+blood Cytokine-cytokine receptor interaction 0 0 0.506289934 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood d18:0-16:0-SM+blood 0 0.536159874 0 serum_bileacids serum_phospholipids 0.483 0.202 no no no no no no HDCA+blood d18:1-16:0-SM+blood 0 0.630126038 0 serum_bileacids serum_phospholipids 0.483 0.14 no no no no no no HDCA+blood d18:1-20:0-SM+blood 0 0.528789979 0 serum_bileacids serum_phospholipids 0.483 0.933 no no no no no no HDCA+blood d18:1-20:1-SM+blood 0 0.545372243 0 serum_bileacids serum_phospholipids 0.483 0.0992 no no no no no no HDCA+blood d18:1-22:1-SM+blood 0 0.567481929 0 serum_bileacids serum_phospholipids 0.483 0.222 no no no no no no HDCA+blood d18:1-24:1-SM+blood 0 0.591434088 0 serum_bileacids serum_phospholipids 0.483 0.0123 no no no no dn dn HDCA+blood DPA+blood 0 0 0.4685154 serum_bileacids serum_ARA 0.483 0.519 no no no no no no HDCA+blood Endocrine resistance 0 0.565201484 0 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood Epstein-Barr virus infection 0 -0.522056333 -0.436950226 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood Focal adhesion 0 0 0.451808735 serum_bileacids kegg 0.483 NA no no no no up up HDCA+blood FoxO signaling pathway 0 0 0.449607474 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood GCA+stool 0 -0.606779876 0 serum_bileacids stool_bileacids 0.483 0.0809 no no no no no no HDCA+blood GLCA+blood 0 0 0.455649083 serum_bileacids serum_bileacids 0.483 0.319 no no no no no no HDCA+blood GnRH signaling pathway 0 0.565201484 0 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood "Growth hormone synthesis, secretion and action" 0 0.573830515 0 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood HDCA+stool 0 0 0.507974499 serum_bileacids stool_bileacids 0.483 0.176 no no no no no no HDCA+blood Hematopoietic cell lineage 0 0 0.483727013 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood Hepatocellular carcinoma 0 0 0.458962831 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood Herpes simplex virus 1 infection 0 -0.522056333 0 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood Hippo signaling pathway 0 0 0.454009995 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood Human cytomegalovirus infection 0 0 -0.493082371 serum_bileacids kegg 0.483 NA no no no no no dn HDCA+blood Human immunodeficiency virus 1 infection 0 0 -0.479324492 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood Human T-cell leukemia virus 1 infection 0 -0.522056333 0 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood Hypertrophic cardiomyopathy 0 0 0.43419865 serum_bileacids kegg 0.483 NA no no no no up up HDCA+blood Kaposi sarcoma-associated herpesvirus infection 0 0 -0.443554007 serum_bileacids kegg 0.483 NA no no no no no dn HDCA+blood Longevity regulating pathway - multiple species 0 -0.513427302 0.41713888 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood Malaria 0 0 -0.450157789 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood Phenylacetic acid+stool 0 0 0.459595975 serum_bileacids stool_cometabolism 0.483 0.785 no no no no no no HDCA+blood Primary immunodeficiency 0 0 0.481525752 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood Proteasome 0 -0.58677406 0 serum_bileacids kegg 0.483 NA no no no no no no HDCA+blood TDCA+stool 0 -0.690065559 0 serum_bileacids stool_bileacids 0.483 0.963 no no no no no no HDCA+blood Thyroid hormone signaling pathway 0 0 0.450157789 serum_bileacids kegg 0.483 NA no no no no no no HDCA+stool 12-ketoDCA+stool 0 0.644484351 0.510869565 stool_bileacids stool_bileacids 0.176 0.505 no no no no no no HDCA+stool 4-hydroxybenzoic acid+stool 0 0 -0.41798419 stool_bileacids stool_cometabolism 0.176 0.0536 no no no no dn no HDCA+stool Adrenergic signaling in cardiomyocytes 0 0.627272727 0 stool_bileacids kegg 0.176 NA no no no no no up HDCA+stool Aldosterone synthesis and secretion 0 0.745454545 0 stool_bileacids kegg 0.176 NA no no no no up up HDCA+stool Allograft rejection 0 -0.709090909 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Amphetamine addiction 0.475748194 0.627272727 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Antigen processing and presentation 0 -0.7 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Apoptosis 0 -0.636363636 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Arachidonic acid metabolism 0 0 -0.500846979 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Autoimmune thyroid disease 0 -0.709090909 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Axon guidance 0 -0.718181818 0 stool_bileacids kegg 0.176 NA no no no no up up HDCA+stool Bacteroides -0.473684211 0 0 LPS-producing stool_bileacids Genus 0.176 0.000267 no no no dn dn up HDCA+stool Biosynthesis of amino acids 0 -0.681818182 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Biosynthesis of cofactors 0 0.727272727 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Butyric acid+stool 0.630546956 0 0 yes stool_bileacids stool_scfa 0.176 0.102 no no no dn no no HDCA+stool CA+stool -0.647058824 0 -0.482213439 stool_bileacids stool_bileacids 0.176 0.827 no no no no no no HDCA+stool Carbon metabolism 0 -0.7 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool CDCA+stool -0.541795666 0 -0.496047431 stool_bileacids stool_bileacids 0.176 0.663 no no no no no no HDCA+stool Cell adhesion molecules 0 -0.690909091 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Cell cycle 0 0.627272727 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Cellular senescence 0 -0.663636364 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Central carbon metabolism in cancer 0 0 0.527950311 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool cGMP-PKG signaling pathway -0.529411765 -0.7 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Chagas disease 0 0 0.45567476 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Chemical carcinogenesis - receptor activation 0 0.681818182 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Chemokine signaling pathway -0.519091847 0 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Cocaine addiction 0 0.645454545 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Collinsella 0 0 -0.697463419 stool_bileacids Genus 0.176 0.128 no no no no no no HDCA+stool Cortisol synthesis and secretion 0 0.681818182 0 stool_bileacids kegg 0.176 NA no no no no no up HDCA+stool Cushing syndrome 0.479876161 0.809090909 0 stool_bileacids kegg 0.176 NA no no no no no up HDCA+stool Cytokine-cytokine receptor interaction -0.475748194 0 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool DCA+stool 0 0.72027972 0.464426877 stool_bileacids stool_bileacids 0.176 0.195 no no no no no no HDCA+stool Dopaminergic synapse 0 0.627272727 0 stool_bileacids kegg 0.176 NA no no no no up no HDCA+stool Endocrine and other factor-regulated calcium reabsorption 0 0.663636364 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Endocytosis 0 -0.754545455 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Epithelial cell signaling in Helicobacter pylori infection -0.545923633 0 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Epstein-Barr virus infection 0 -0.681818182 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Fc epsilon RI signaling pathway 0 -0.654545455 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Fc gamma R-mediated phagocytosis 0 -0.854545455 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Fluid shear stress and atherosclerosis 0 -0.627272727 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Glucagon signaling pathway 0 0.654545455 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool GnRH signaling pathway 0 0.609090909 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Graft-versus-host disease 0 -0.709090909 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool HCA+stool 0 -0.612691249 0 stool_bileacids stool_bileacids 0.176 0.155 no no no no no no HDCA+stool Hepatitis B -0.547987616 0 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Hepatitis C 0 0 0.462450593 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Herpes simplex virus 1 infection 0 -0.690909091 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Human cytomegalovirus infection 0 -0.745454545 0 stool_bileacids kegg 0.176 NA no no no no no dn HDCA+stool Human immunodeficiency virus 1 infection 0 -0.681818182 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Human papillomavirus infection 0 -0.627272727 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Human T-cell leukemia virus 1 infection 0 -0.672727273 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool IL-17 signaling pathway -0.704850361 -0.781818182 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Inflammatory bowel disease 0 -0.609090909 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Influenza A 0 -0.627272727 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Insulin secretion 0 0.8 0 yes stool_bileacids kegg 0.176 NA no no no no up up HDCA+stool Intestinal immune network for IgA production 0 -0.654545455 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Leukocyte transendothelial migration 0 -0.790909091 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Lipid and atherosclerosis 0 -0.727272727 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Lysosome 0 -0.881818182 -0.500846979 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool MAPK signaling pathway 0 0 0.518915867 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Measles 0 0 0.500846979 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Morphine addiction 0 0.8 0 stool_bileacids kegg 0.176 NA no no no no up up HDCA+stool mRNA surveillance pathway 0 0.645454545 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Natural killer cell mediated cytotoxicity 0 -0.754545455 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Neuroactive ligand-receptor interaction 0 -0.909090909 0 stool_bileacids kegg 0.176 NA no no no up up up HDCA+stool Neutrophil extracellular trap formation -0.492260062 -0.872727273 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool NF-kappa B signaling pathway -0.481940144 0 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool NOD-like receptor signaling pathway 0 0 0.459062676 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Odoribacter 0 -0.615384615 0 butyrate-producing stool_bileacids Genus 0.176 0.798 no no no no no no HDCA+stool Osteoclast differentiation -0.568627451 -0.854545455 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool p53 signaling pathway 0 0.781818182 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Pancreatic secretion 0 0.636363636 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Pathogenic Escherichia coli infection 0 -0.872727273 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Pathways in cancer 0 0 0.604743083 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 0.568605308 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Peroxisome -0.475748194 -0.690909091 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Pertussis 0 -0.790909091 0 stool_bileacids kegg 0.176 NA no no no no no dn HDCA+stool Phagosome 0 -0.863636364 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool PPAR signaling pathway 0 -0.663636364 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Prolactin signaling pathway 0 -0.663636364 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Protein processing in endoplasmic reticulum 0.55624355 0 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Pyramidobacter 0 0 0.414706784 stool_bileacids Genus 0.176 0.45 no no no no no no HDCA+stool Regulation of lipolysis in adipocytes 0 0.627272727 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Rheumatoid arthritis 0 -0.809090909 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool RIG-I-like receptor signaling pathway -0.622291022 0 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Ruminococcus -0.52453321 0 0 stool_bileacids Genus 0.176 0.0679 no no no no no dn HDCA+stool Ruminococcus 0.568627451 0 0 acetate-producing stool_bileacids Genus 0.176 0.335 no no no no no no HDCA+stool Salmonella infection 0 -0.790909091 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Signaling pathways regulating pluripotency of stem cells 0 0 0.489553924 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Sphingolipid signaling pathway 0 -0.8 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Spliceosome 0 0.654545455 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Staphylococcus aureus infection 0 -0.890909091 0 stool_bileacids kegg 0.176 NA no no no up no no HDCA+stool Systemic lupus erythematosus 0 -0.872727273 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool T cell receptor signaling pathway 0 0 0.674760023 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Thyroid hormone synthesis 0.529411765 0.763636364 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Toll-like receptor signaling pathway -0.471620227 0 0 yes stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Transcriptional misregulation in cancer -0.5500516 0 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Tuberculosis 0 -0.890909091 0 stool_bileacids kegg 0.176 NA no no no no no dn HDCA+stool Type I diabetes mellitus 0 -0.709090909 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Vasopressin-regulated water reabsorption 0 0.690909091 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Viral carcinogenesis 0 -0.772727273 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Viral myocarditis 0 -0.709090909 0 stool_bileacids kegg 0.176 NA no no no no no no HDCA+stool Yersinia infection 0 -0.727272727 0 stool_bileacids kegg 0.176 NA no no no no no no Heart_Rate+clinic 15-HETE+blood 0.509933876 0 0 clinic serum_ARA 0.00151 0.819 up up no no no no Heart_Rate+clinic 16:0/16:0-PC+blood 0 0 0.46 clinic serum_phospholipids 0.00151 0.00079 up up no no up up Heart_Rate+clinic 16:0/18:2-PI+blood 0 -0.692857143 0 clinic serum_phospholipids 0.00151 0.269 up up no no no no Heart_Rate+clinic 16:0/20:5-PC+blood 0 0.617857143 0 clinic serum_phospholipids 0.00151 0.628 up up no no no no Heart_Rate+clinic 16:0/22:6-PC+blood 0 0.582142857 0 clinic serum_phospholipids 0.00151 4.53E-05 up up no no up up Heart_Rate+clinic 18:0-LPE+blood -0.521155831 0 0 clinic serum_phospholipids 0.00151 0.491 up up no no no no Heart_Rate+clinic 18:0/18:0-PC+blood -0.568627451 0 0 clinic serum_phospholipids 0.00151 0.426 up up no no no no Heart_Rate+clinic 18:0/18:1-PC+blood -0.554179567 0 0 clinic serum_phospholipids 0.00151 0.393 up up no no no no Heart_Rate+clinic 18:0/20:4-PC+blood 0 0.592857143 0 clinic serum_phospholipids 0.00151 0.454 up up no no no no Heart_Rate+clinic 18:0/20:5-PC+blood 0 0.653571429 0 clinic serum_phospholipids 0.00151 0.17 up up no no no no Heart_Rate+clinic 18:1/18:1-PE+blood 0 -0.610714286 0 clinic serum_phospholipids 0.00151 1.03E-05 up up no up up no Heart_Rate+clinic 18:1/20:4-PC+blood 0 0.557142857 0 clinic serum_phospholipids 0.00151 0.582 up up no no no no Heart_Rate+clinic 20:1-LPA+blood 0.572755418 0 0 clinic serum_phospholipids 0.00151 0.0187 up up no dn dn no Heart_Rate+clinic 20:2+blood 0.473684211 0 0 clinic serum_fattyacid 0.00151 0.478 up up no no no no Heart_Rate+clinic 20:4n6+blood 0 0.596428571 0 clinic serum_fattyacid 0.00151 0.133 up up no no no no Heart_Rate+clinic 20:5/18:0-PC+blood 0 0.532142857 0 clinic serum_phospholipids 0.00151 3.97E-06 up up no no up up Heart_Rate+clinic 20:5n3+blood 0 0.607142857 0 clinic serum_fattyacid 0.00151 0.988 up up no no no no Heart_Rate+clinic 22:6n3+blood 0 0.525 0 clinic serum_fattyacid 0.00151 0.792 up up no no no no Heart_Rate+clinic 9-HODE+blood 0.475748194 0 0.575384615 clinic serum_ARA 0.00151 0.297 up up no no no no Heart_Rate+clinic AA+blood 0 0.592857143 0 clinic serum_ARA 0.00151 0.212 up up no no no no Heart_Rate+clinic Adherens junction 0 -0.496103896 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Alistipes 0 0 0.460177985 clinic Genus 0.00151 0.0114 up up no no up no Heart_Rate+clinic Alzheimer disease 0 -0.535064935 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Amyotrophic lateral sclerosis 0 -0.531168831 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Arrhythmogenic right ventricular cardiomyopathy 0 -0.475324675 0 clinic kegg 0.00151 NA up up no no up up Heart_Rate+clinic Bacteroides 0 0.442123094 0 LPS-producing clinic Genus 0.00151 0.000267 up up no dn dn up Heart_Rate+clinic C-peptide 0 0 -0.531856379 clinic DM-assocaited hormones 0.00151 0.228 up up no no no no Heart_Rate+clinic Calcium signaling pathway 0 -0.462337662 0 clinic kegg 0.00151 NA up up no no up up Heart_Rate+clinic Cardiac muscle contraction 0 -0.515584416 0 clinic kegg 0.00151 NA up up no no no up Heart_Rate+clinic Cholinergic synapse 0 0.476623377 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Circadian entrainment 0 -0.485714286 0 clinic kegg 0.00151 NA up up no no up up Heart_Rate+clinic Cocaine addiction 0 -0.444155844 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic d18:1-20:1-SM+blood 0.496388029 0 0 clinic serum_phospholipids 0.00151 0.0992 up up no no no no Heart_Rate+clinic Diabetic cardiomyopathy 0 -0.533766234 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Dilated cardiomyopathy 0 -0.592207792 0 clinic kegg 0.00151 NA up up no no up up Heart_Rate+clinic DMG+blood 0 -0.514285714 0 clinic serum_choline 0.00151 0.909 up up no no no no Heart_Rate+clinic Endocrine and other factor-regulated calcium reabsorption 0 -0.47012987 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic EPA+blood 0 0.642857143 0 clinic serum_ARA 0.00151 0.212 up up no no no no Heart_Rate+clinic FoxO signaling pathway 0 0.490909091 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Gastric acid secretion 0 -0.577922078 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic GCDCA+blood -0.469556244 0 0 clinic serum_bileacids 0.00151 0.31 up up no no no no Heart_Rate+clinic Gemmiger -0.46454165 0 0 butyrate-producing clinic Genus 0.00151 0.595 up up no no no no Heart_Rate+clinic GPC+blood 0.599587203 0 0 clinic serum_choline 0.00151 0.00427 up up no no up up Heart_Rate+clinic HDCA+blood 0.481869425 0 0 clinic serum_bileacids 0.00151 0.483 up up no no no no Heart_Rate+clinic Hepatocellular carcinoma 0 -0.493506494 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Huntington disease 0 -0.554545455 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Hypertrophic cardiomyopathy 0 -0.474025974 0 clinic kegg 0.00151 NA up up no no up up Heart_Rate+clinic IL-1ra -0.615384615 0 0 yes clinic serum_cytokines 0.00151 0.0288 up up no no up no Heart_Rate+clinic Inflammatory mediator regulation of TRP channels 0 -0.438961039 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic iso-DCA+blood 0.533539732 0 0 clinic serum_bileacids 0.00151 0.38 up up no no no no Heart_Rate+clinic L-2-Aminobutyric acid+blood 0 0.557142857 0 yes clinic serum_aminoacids 0.00151 0.000328 up up no up up no Heart_Rate+clinic L-Proline+blood 0 -0.821428571 0 yes clinic serum_aminoacids 0.00151 0.00265 up up no up up no Heart_Rate+clinic Long-term depression 0 -0.492207792 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Longevity regulating pathway - multiple species 0 0.457142857 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic MAPK signaling pathway 0 0.627272727 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Measles 0 0.48961039 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Melanogenesis 0 -0.457142857 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Mineral absorption 0 -0.492207792 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Mitophagy - animal 0 -0.522077922 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Morphine addiction 0 -0.479220779 0 clinic kegg 0.00151 NA up up no no up up Heart_Rate+clinic Non-alcoholic fatty liver disease 0 -0.535064935 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Oscillospira 0 0.456804065 0 LPS-producing clinic Genus 0.00151 0.62 up up no no no no Heart_Rate+clinic Oxidative phosphorylation 0 -0.561038961 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Oxytocin signaling pathway 0 -0.474025974 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Pancreatic secretion 0 -0.464935065 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Parabacteroides 0 0.473743648 0 clinic Genus 0.00151 4.19E-05 up up no no up up Heart_Rate+clinic Parkinson disease 0 -0.564935065 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Pathways of neurodegeneration - multiple diseases 0 -0.536363636 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic PI3K-Akt signaling pathway 0 0.641558442 0 yes clinic kegg 0.00151 NA up up no no up up Heart_Rate+clinic Platelet activation 0 -0.58961039 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Progesterone-mediated oocyte maturation 0 0.48961039 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Rap1 signaling pathway 0 -0.622077922 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Renin secretion 0 -0.516883117 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Roseburia -0.424901186 0 0 butyrate-producing clinic Genus 0.00151 0.495 up up no no no no Heart_Rate+clinic Ruminococcus 0 -0.477351857 0 clinic Genus 0.00151 0.0679 up up no no no dn Heart_Rate+clinic Shigellosis 0 -0.5 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Spliceosome 0 0.450649351 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic T cell receptor signaling pathway 0 0.538961039 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic TCA+stool 0 -0.751710379 0 clinic stool_bileacids 0.00151 0.458 up up no no no no Heart_Rate+clinic Thermogenesis 0 -0.450649351 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Thyroid hormone signaling pathway 0 -0.537662338 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Thyroid hormone synthesis 0 -0.502597403 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic TLCA+stool 0.65380417 0 0 clinic stool_bileacids 0.00151 0.243 up up no no no no Heart_Rate+clinic TXB2+blood 0 0.573570391 0 yes clinic serum_ARA 0.00151 0.0644 up up no dn no no Heart_Rate+clinic Ubiquitin mediated proteolysis 0 -0.496103896 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Vascular smooth muscle contraction 0 -0.605194805 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Vasopressin-regulated water reabsorption 0 -0.47012987 0 clinic kegg 0.00151 NA up up no no no no Heart_Rate+clinic Vibrio cholerae infection 0 -0.642857143 0 clinic kegg 0.00151 NA up up no no no no Hedgehog signaling pathway 2-Oxocarboxylic acid metabolism 0 0.614624506 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway ABC transporters 0 0.557312253 0.486229086 kegg kegg NA NA no no no no up up Hedgehog signaling pathway Adrenergic signaling in cardiomyocytes 0.439130435 0 0 kegg kegg NA NA no no no no no up Hedgehog signaling pathway "Alanine, aspartate and glutamate metabolism" 0 0 -0.500900901 kegg kegg NA NA no no no no no no Hedgehog signaling pathway alpha-Linolenic acid metabolism -0.625217391 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Amino sugar and nucleotide sugar metabolism -0.583478261 0.455533597 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Aminoacyl-tRNA biosynthesis 0 0.830039526 0.497297297 kegg kegg NA NA no no no no no no Hedgehog signaling pathway AMPK signaling pathway 0 0.433794466 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Antifolate resistance 0 0.779644269 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Apoptosis -0.49826087 -0.559288538 -0.42985843 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Apoptosis - multiple species 0 0.654150198 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Arachidonic acid metabolism 0 0 -0.615701416 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Arginine and proline metabolism -0.473043478 -0.483201581 -0.403346203 kegg kegg NA NA no no no no up no Hedgehog signaling pathway Arginine biosynthesis 0 -0.423913043 -0.627027027 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Ascorbate and aldarate metabolism 0 0 0.421879022 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Autophagy - other 0 0 0.643243243 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Basal transcription factors 0 0.760869565 0.63989704 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Base excision repair 0 0.841897233 0.447104247 kegg kegg NA NA no no no no no no Hedgehog signaling pathway beta-Alanine metabolism -0.47826087 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Biosynthesis of amino acids -0.69826087 -0.563241107 -0.726126126 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Biosynthesis of cofactors 0 0.54743083 -0.441441441 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Butanoate metabolism 0 0.536561265 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Calcium signaling pathway 0.66 0 0 kegg kegg NA NA no no no no up up Hedgehog signaling pathway cAMP signaling pathway 0.443478261 -0.519762846 0 yes kegg kegg NA NA no no no no up up Hedgehog signaling pathway Carbon metabolism -0.64173913 0 -0.548519949 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Cardiac muscle contraction 0.515652174 0 0 kegg kegg NA NA no no no no no up Hedgehog signaling pathway Cell cycle 0 0.874505929 0.783783784 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Cellular senescence 0 -0.43972332 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway cGMP-PKG signaling pathway 0 -0.701581028 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Chemokine signaling pathway 0 -0.690711462 -0.485714286 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Citrate cycle (TCA cycle) 0 0.43972332 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway DNA replication 0 0.703557312 0.461261261 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Drug metabolism - cytochrome P450 -0.471304348 0.433794466 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Drug metabolism - other enzymes -0.527826087 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Endocrine resistance 0.573043478 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Endocytosis -0.450434783 -0.461462451 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway ErbB signaling pathway 0.607826087 0 0.716602317 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Ether lipid metabolism 0.548695652 0.501976285 0.505534106 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Fanconi anemia pathway 0 0.89229249 0.614157014 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Fatty acid metabolism -0.434782609 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Ferroptosis 0 -0.489130435 -0.611325611 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Folate biosynthesis 0 0.441699605 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Fructose and mannose metabolism -0.610434783 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Galactose metabolism -0.494782609 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Glutathione metabolism 0 0 -0.581724582 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Glycerolipid metabolism 0 0.433794466 0.733590734 kegg kegg NA NA no no no no no up Hedgehog signaling pathway Glycerophospholipid metabolism 0.439130435 0.490118577 0.786615187 kegg kegg NA NA no no no no no up Hedgehog signaling pathway "Glycine, serine and threonine metabolism" 0 0 -0.448648649 kegg kegg NA NA no no no no up no Hedgehog signaling pathway Glycolysis / Gluconeogenesis -0.64 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.664031621 0.558043758 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0.657391304 0 0.521235521 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Glycosaminoglycan degradation 0 -0.490118577 0 kegg kegg NA NA no no no no no up Hedgehog signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 0.678853755 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.56 0 0.461776062 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.586956522 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Glyoxylate and dicarboxylate metabolism 0 -0.459486166 -0.601801802 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Homologous recombination 0 0.721343874 0.544401544 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Inositol phosphate metabolism 0 0.657114625 0.757014157 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Lysine degradation 0 0.794466403 0.855855856 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Lysosome 0 -0.769762846 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Mannose type O-glycan biosynthesis 0.604347826 0.608695652 0.831145431 kegg kegg NA NA no no no no no no Hedgehog signaling pathway MAPK signaling pathway 0 0.517786561 0.564993565 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Metabolism of xenobiotics by cytochrome P450 -0.484347826 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Mismatch repair 0 0.551383399 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway mRNA surveillance pathway 0.68173913 0.565217391 0.815186615 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Mucin type O-glycan biosynthesis 0 0.466403162 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway N-Glycan biosynthesis 0.511304348 0.671936759 0.680823681 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Necroptosis 0 0 -0.584041184 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Neuroactive ligand-receptor interaction 0 -0.580039526 -0.598970399 kegg kegg NA NA no no no up up up Hedgehog signaling pathway Nicotinate and nicotinamide metabolism 0 -0.48715415 -0.482625483 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Nitrogen metabolism -0.487826087 -0.519762846 -0.594337194 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Notch signaling pathway 0.584347826 0 0.718918919 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Nucleotide excision repair 0 0.727272727 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway One carbon pool by folate 0 0.790513834 0.664350064 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Oocyte meiosis 0 0 0.498841699 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Other glycan degradation -0.494782609 0 0.626254826 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Other types of O-glycan biosynthesis 0 0.760869565 0.853796654 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Oxidative phosphorylation 0.468695652 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway p53 signaling pathway 0.444347826 0.510869565 0.563191763 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Pantothenate and CoA biosynthesis 0 -0.436758893 -0.447876448 kegg kegg NA NA no no no no no dn Hedgehog signaling pathway Pentose and glucuronate interconversions 0 0.545454545 0.401287001 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Pentose phosphate pathway -0.529565217 -0.671936759 -0.632432432 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Peroxisome 0 0 -0.593822394 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Phagosome -0.503478261 -0.581027668 -0.528185328 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Phenylalanine metabolism 0 0.449604743 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Phosphatidylinositol signaling system 0.819130435 0.755928854 0.863320463 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Platinum drug resistance 0 0.752964427 0.541055341 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Porphyrin and chlorophyll metabolism 0 0 -0.467696268 kegg kegg NA NA no no no no no no Hedgehog signaling pathway PPAR signaling pathway -0.514782609 -0.454545455 -0.496525097 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Protein export 0.432173913 0 0.592792793 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Protein processing in endoplasmic reticulum 0 0.613636364 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Purine metabolism 0 0.480237154 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Pyrimidine metabolism -0.419130435 0.56027668 0.402831403 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Ras signaling pathway 0 0 0.603603604 yes kegg kegg NA NA no no no no up up Hedgehog signaling pathway Retinol metabolism -0.42173913 0.616600791 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Ribosome 0.437391304 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Ribosome biogenesis in eukaryotes 0.405217391 0.900197628 0.743629344 kegg kegg NA NA no no no no no no Hedgehog signaling pathway RNA degradation 0.704347826 0.548418972 0.841698842 kegg kegg NA NA no no no no no no Hedgehog signaling pathway RNA polymerase 0 0.779644269 0.517117117 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Selenocompound metabolism 0 0.816205534 0.681081081 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Sphingolipid signaling pathway 0.474782609 -0.424901186 0.431917632 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Spliceosome 0 0.756916996 0.722779923 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Starch and sucrose metabolism -0.543478261 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Steroid biosynthesis 0.480869565 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Steroid hormone biosynthesis -0.489565217 0 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Sulfur metabolism 0 0 -0.598970399 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Synthesis and degradation of ketone bodies 0 0.701581028 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Taurine and hypotaurine metabolism 0 0 0.673359073 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Terpenoid backbone biosynthesis 0 0.590909091 0.488803089 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Tyrosine metabolism 0 0.502964427 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 0.64229249 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway "Valine, leucine and isoleucine degradation" 0 0.604743083 0 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Various types of N-glycan biosynthesis 0 0.692687747 0.617245817 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Viral protein interaction with cytokine and cytokine receptor 0 -0.678853755 -0.623423423 kegg kegg NA NA no no no no no no Hedgehog signaling pathway Wnt signaling pathway 0.730434783 0.647233202 0.831402831 kegg kegg NA NA no no no no no no Height+clinic 12-HEPE+blood 0 0.531685128 0 clinic serum_ARA 0.358 0.312 no no no no no no Height+clinic 12-ketoDCA+blood 0 0.530999412 0 clinic serum_bileacids 0.358 0.517 no no no no no no Height+clinic 13-HODE+blood 0 0 0.492307692 clinic serum_ARA 0.358 0.32 no no no no no no Height+clinic 16:0/16:1-PC+blood 0 -0.653571429 0 clinic serum_phospholipids 0.358 0.00283 no no no up up no Height+clinic 16:0/18:1-PC+blood 0.599587203 0 0 clinic serum_phospholipids 0.358 6.15E-07 no no no up up up Height+clinic 16:0/18:2-PC+blood 0.479876161 0 0 clinic serum_phospholipids 0.358 3.24E-06 no no no no up up Height+clinic 16:0/18:2-PI+blood -0.475748194 -0.660714286 0 clinic serum_phospholipids 0.358 0.269 no no no no no no Height+clinic 16:0/20:3-PC+blood 0 0 -0.41 clinic serum_phospholipids 0.358 5.43E-06 no no no no up up Height+clinic 16:0/20:4-PI+blood -0.715170279 0 -0.440769231 clinic serum_phospholipids 0.358 0.558 no no no no no no Height+clinic 16:0/20:5-PC+blood 0 0.575 0 clinic serum_phospholipids 0.358 0.628 no no no no no no Height+clinic 16:1/18:2-PG+blood 0.484004128 0 0 clinic serum_phospholipids 0.358 1.40E-08 no no no no up up Height+clinic 18:0-LPA+blood 0 0 -0.418461538 clinic serum_phospholipids 0.358 0.0725 no no no no dn no Height+clinic 18:0-LPC+blood -0.568627451 0 0 clinic serum_phospholipids 0.358 0.554 no no no no no no Height+clinic 18:0-LPE+blood -0.475748194 0 0 clinic serum_phospholipids 0.358 0.491 no no no no no no Height+clinic 18:0/16:0-PC+blood 0.572755418 0 0 clinic serum_phospholipids 0.358 9.64E-07 no no no up up up Height+clinic 18:0/18:1-PE+blood 0 -0.575 0 clinic serum_phospholipids 0.358 0.00716 no no no up up no Height+clinic 18:0/18:2-PC+blood 0.510835913 0 0 clinic serum_phospholipids 0.358 1.74E-06 no no no no up up Height+clinic 18:0/20:3-PC+blood -0.566563467 0 -0.585384615 clinic serum_phospholipids 0.358 0.0682 no no no no up no Height+clinic 18:0/20:3-PI+blood 0 -0.65 0 clinic serum_phospholipids 0.358 0.377 no no no no no no Height+clinic 18:0/20:4-PC+blood 0 0.667857143 0 clinic serum_phospholipids 0.358 0.454 no no no no no no Height+clinic 18:0/20:5-PC+blood 0 0.653571429 0 clinic serum_phospholipids 0.358 0.17 no no no no no no Height+clinic 18:1/18:0-PC+blood 0.494324045 0 0 clinic serum_phospholipids 0.358 1.83E-06 no no no no up up Height+clinic 18:1/18:1-PC+blood 0 0 -0.44 clinic serum_phospholipids 0.358 1.34E-05 no no no no up up Height+clinic 18:1/18:1-PE+blood 0 -0.725 0 clinic serum_phospholipids 0.358 1.03E-05 no no no up up no Height+clinic 18:1/18:2-PG+blood 0.481940144 0 0 clinic serum_phospholipids 0.358 5.58E-07 no no no no up up Height+clinic 18:1/20:4-PC+blood 0 0.575 0 clinic serum_phospholipids 0.358 0.582 no no no no no no Height+clinic 18:2-LPC+blood 0.488132095 0 0 clinic serum_phospholipids 0.358 0.00743 no no no dn no up Height+clinic 18:2/16:0-PC+blood 0.642930857 0 0 clinic serum_phospholipids 0.358 8.67E-05 no no no no up up Height+clinic 18:2/18:2-PC+blood 0.477812178 0 0 clinic serum_phospholipids 0.358 1.98E-05 no no no dn up up Height+clinic 18:2/20:4-PC+blood 0 0.532142857 0 clinic serum_phospholipids 0.358 0.0145 no no no no no up Height+clinic 18:3n3+blood 0 0 0.536923077 clinic serum_fattyacid 0.358 0.291 no no no no no no Height+clinic 18:3n6+blood -0.558307534 0 0 clinic serum_fattyacid 0.358 0.0463 no no no up no dn Height+clinic 20:2/18:0-PC+blood -0.529411765 0 -0.569230769 clinic serum_phospholipids 0.358 0.0427 no no no no up no Height+clinic 20:3/16:0-PC+blood 0.479876161 0 0 clinic serum_phospholipids 0.358 0.00405 no no no no up up Height+clinic 20:3n6+blood -0.630546956 -0.657142857 -0.486153846 clinic serum_fattyacid 0.358 0.0884 no no no up no no Height+clinic 20:4-LPC+blood 0 0.682142857 0 clinic serum_phospholipids 0.358 0.949 no no no no no no Height+clinic 20:4n6+blood 0 0.6 0 clinic serum_fattyacid 0.358 0.133 no no no no no no Height+clinic 22:6n3+blood -0.574819401 0 0 clinic serum_fattyacid 0.358 0.792 no no no no no no Height+clinic 4-hydroxy-3-methoxymandelic acid+urine 0 0 -0.421538462 clinic urine_cometabolism 0.358 0.973 no no no no no no Height+clinic 4-hydroxybenzoic acid+urine 0 0.495098039 0 clinic urine_cometabolism 0.358 0.52 no no no no no no Height+clinic Apoptosis 0.522303783 0 0 clinic kegg 0.358 NA no no no no no no Height+clinic C-peptide 0 -0.626199887 -0.458212376 clinic DM-assocaited hormones 0.358 0.228 no no no no no no Height+clinic Cholinergic synapse 0 0.488311688 0 clinic kegg 0.358 NA no no no no no no Height+clinic Coprococcus -0.446640316 0 0 butyrate-producing clinic Genus 0.358 0.612 no no no no no no Height+clinic Cytosolic DNA-sensing pathway 0.514398645 0 0 clinic kegg 0.358 NA no no no no no no Height+clinic d18:1-18:0-SM+blood 0.543859649 0 0 clinic serum_phospholipids 0.358 0.97 no no no no no no Height+clinic d18:1-18:1-SM+blood 0.484004128 0 0 clinic serum_phospholipids 0.358 0.916 no no no no no no Height+clinic d18:1-20:1-SM+blood 0.539731682 0 0 clinic serum_phospholipids 0.358 0.0992 no no no no no no Height+clinic EPA+blood 0 0.653571429 0 clinic serum_ARA 0.358 0.212 no no no no no no Height+clinic Ethanolamine+blood 0.490196078 0 0 clinic serum_aminoacids 0.358 0.122 no no no up no no Height+clinic Gastric cancer -0.486166008 0 0 clinic kegg 0.358 NA no no no no no no Height+clinic GCDCA+stool -0.5 0 0 yes clinic stool_bileacids 0.358 0.0471 no no no no dn no Height+clinic GLCA+blood 0 0 0.449552064 clinic serum_bileacids 0.358 0.319 no no no no no no Height+clinic Glycine+blood 0.570691434 0 0 clinic serum_aminoacids 0.358 0.00408 no no no dn no up Height+clinic HDCA+blood 0.481869425 0.530999412 0 clinic serum_bileacids 0.358 0.483 no no no no no no Height+clinic Homovanillic acid+urine -0.504643963 0 0 clinic urine_cometabolism 0.358 0.45 no no no no no no Height+clinic IP-10 0 -0.477192982 0 clinic serum_cytokines 0.358 0.394 no no no no no no Height+clinic iso-DCA+blood 0.581011352 0 0 clinic serum_bileacids 0.358 0.38 no no no no no no Height+clinic iso-LCA+blood 0 0.542185151 0 clinic serum_bileacids 0.358 0.507 no no no no no no Height+clinic L-Aspartic acid+blood 0.543859649 0 0 yes clinic serum_aminoacids 0.358 0.0226 no no no up up no Height+clinic L-Phenylalanine+blood 0 -0.689285714 0 yes clinic serum_aminoacids 0.358 0.0103 no no no up up no Height+clinic L-Proline+blood 0 -0.753571429 0 yes clinic serum_aminoacids 0.358 0.00265 no no no up up no Height+clinic L-Tryptophan+blood 0 -0.632142857 0 clinic serum_aminoacids 0.358 0.164 no no no no no no Height+clinic L-Tyrosine+blood 0 -0.739285714 0 yes clinic serum_aminoacids 0.358 0.00913 no no no up up no Height+clinic Leptin 0 0 -0.44171123 clinic DM-assocaited hormones 0.358 0.706 no no no no no no Height+clinic n6/n3+blood 0.510835913 0 0 clinic serum_fattyacid 0.358 0.226 no no no no no no Height+clinic P-hydroxyhippuric acid+urine -0.51496388 0 0 clinic urine_cometabolism 0.358 0.436 no no no no no no Height+clinic Parabacteroides 0 0.448898927 0 clinic Genus 0.358 4.19E-05 no no no no up up Height+clinic Paraprevotella 0 -0.540367726 0 clinic Genus 0.358 0.118 no no no no no no Height+clinic Pathogenic Escherichia coli infection 0.429700734 0 0 clinic kegg 0.358 NA no no no no no no Height+clinic Phenylacetic acid+stool 0.555882353 0 0 clinic stool_cometabolism 0.358 0.785 no no no no no no Height+clinic PI3K-Akt signaling pathway 0 0.467532468 0 yes clinic kegg 0.358 NA no no no no up up Height+clinic PUFA%+blood 0.616099071 0 0 clinic serum_fattyacid 0.358 0.0013 no no no dn no up Height+clinic Roseburia 0 -0.462016398 0 butyrate-producing clinic Genus 0.358 0.495 no no no no no no Height+clinic SFA%+blood 0.545923633 0 0 clinic serum_fattyacid 0.358 0.0236 no no no no up no Height+clinic TCA+stool 0 -0.619591585 -0.425183512 clinic stool_bileacids 0.358 0.458 no no no no no no Height+clinic TXB2+blood 0 0.61598878 0 yes clinic serum_ARA 0.358 0.0644 no no no dn no no Height+clinic UFA%+blood 0.55624355 0 0 clinic serum_fattyacid 0.358 0.0236 no no no no dn no Height+clinic Visfatin 0 0 0.455767762 clinic DM-assocaited hormones 0.358 0.0229 no no no dn no up Hematopoietic cell lineage 2-Oxocarboxylic acid metabolism 0 0.529644269 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Adherens junction 0 0.445652174 0.455083655 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Amino sugar and nucleotide sugar metabolism 0 0 0.443758044 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Aminoacyl-tRNA biosynthesis 0 0.419960474 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage AMPK signaling pathway 0 -0.462450593 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Apoptosis - multiple species 0.41826087 0 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Arginine biosynthesis 0 -0.414031621 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Ascorbate and aldarate metabolism 0 0.492094862 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Autophagy - animal 0 -0.510869565 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Axon guidance -0.476521739 0 0 kegg kegg NA NA no no no no up up Hematopoietic cell lineage beta-Alanine metabolism 0.451304348 0.751976285 0.726640927 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Biosynthesis of unsaturated fatty acids 0 0.56027668 0.624195624 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Butanoate metabolism 0 0.708498024 0.471299871 kegg kegg NA NA no no no no no no Hematopoietic cell lineage C-type lectin receptor signaling pathway 0 0 -0.454568855 kegg kegg NA NA no no no no no no Hematopoietic cell lineage cAMP signaling pathway -0.529565217 -0.606719368 -0.595109395 yes kegg kegg NA NA no no no no up up Hematopoietic cell lineage Carbon metabolism 0 0.701581028 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Chemokine signaling pathway -0.453913043 0 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Citrate cycle (TCA cycle) 0 0.698616601 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Clostridium 0 0.566455843 0 kegg Genus NA 0.925 no no no no no no Hematopoietic cell lineage Cysteine and methionine metabolism 0 0.659090909 0.400772201 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Cytokine-cytokine receptor interaction 0 0 0.437837838 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Cytosolic DNA-sensing pathway -0.584347826 -0.475296443 -0.51994852 kegg kegg NA NA no no no no no no Hematopoietic cell lineage DNA replication 0 0.446640316 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Drug metabolism - cytochrome P450 0 0.599802372 0.576061776 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Drug metabolism - other enzymes 0 0.628458498 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Fatty acid degradation 0.424347826 0 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Fatty acid elongation 0 0.752964427 0.676447876 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Fatty acid metabolism 0.424347826 0 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Ferroptosis 0 -0.552371542 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Focal adhesion 0 0.590909091 0.524066924 kegg kegg NA NA no no no no up up Hematopoietic cell lineage Gap junction 0 -0.658102767 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Glycolysis / Gluconeogenesis 0 0.734189723 0.570913771 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.506916996 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 -0.487516088 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Hippo signaling pathway 0 0.462450593 0.516087516 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Histidine metabolism 0.42173913 0 0.585585586 kegg kegg NA NA no no no no no no Hematopoietic cell lineage JAK-STAT signaling pathway 0 -0.481225296 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Longevity regulating pathway 0 -0.727272727 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Longevity regulating pathway - multiple species 0 0.428853755 0.436036036 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Metabolism of xenobiotics by cytochrome P450 0 0.684782609 0.584041184 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Mismatch repair 0 0.437747036 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Necroptosis 0 -0.520750988 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage NF-kappa B signaling pathway 0 -0.469367589 -0.485456885 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Nitrogen metabolism 0 -0.496047431 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Non-homologous end-joining 0 0.756916996 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Oocyte meiosis 0 0.627470356 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage p53 signaling pathway 0 -0.445652174 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Pentose and glucuronate interconversions 0 0.586956522 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Phenylalanine metabolism 0 0.665019763 0.495495495 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Phospholipase D signaling pathway 0 -0.699604743 -0.421364221 kegg kegg NA NA no no no no up up Hematopoietic cell lineage Primary bile acid biosynthesis 0 0.722332016 0.611583012 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Propanoate metabolism 0 0.663043478 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Proteasome 0 0.624505929 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Pyrimidine metabolism 0.5 0 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Pyruvate metabolism 0 0.559288538 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Retinol metabolism 0 0.422924901 0.402316602 kegg kegg NA NA no no no no no no Hematopoietic cell lineage RIG-I-like receptor signaling pathway 0 -0.481225296 -0.516344916 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Steroid biosynthesis 0 0.517786561 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Steroid hormone biosynthesis 0 0.635375494 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Taurine and hypotaurine metabolism 0 -0.520750988 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage TGF-beta signaling pathway 0 0.490118577 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Thiamine metabolism 0 0.461462451 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Tight junction 0 0.453557312 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Toll-like receptor signaling pathway 0 0 -0.461518662 yes kegg kegg NA NA no no no no no no Hematopoietic cell lineage Tryptophan metabolism 0.420869565 0.781620553 0 kegg kegg NA NA no no no no up no Hematopoietic cell lineage Tyrosine metabolism 0 0.539525692 0.517631918 kegg kegg NA NA no no no no no no Hematopoietic cell lineage Ubiquinone and other terpenoid-quinone biosynthesis 0 0.495059289 0 kegg kegg NA NA no no no no no no Hematopoietic cell lineage "Valine, leucine and isoleucine degradation" 0 0.632411067 0.547747748 kegg kegg NA NA no no no no no no Hepatitis B 2-Oxocarboxylic acid metabolism -0.577391304 -0.563241107 0 kegg kegg NA NA no no no no no no Hepatitis B ABC transporters 0 0.479249012 0 kegg kegg NA NA no no no no up up Hepatitis B Adherens junction -0.58 -0.834980237 -0.430888031 kegg kegg NA NA no no no no no no Hepatitis B Adipocytokine signaling pathway 0 0.633399209 0 kegg kegg NA NA no no no no no no Hepatitis B Adrenergic signaling in cardiomyocytes 0 -0.624505929 0 kegg kegg NA NA no no no no no up Hepatitis B African trypanosomiasis 0.427826087 0.526679842 0 kegg kegg NA NA no no no no no no Hepatitis B AGE-RAGE signaling pathway in diabetic complications 0.477391304 0.851778656 0.659202059 kegg kegg NA NA no no no no no no Hepatitis B "Alanine, aspartate and glutamate metabolism" 0.463478261 0.830039526 0 kegg kegg NA NA no no no no no no Hepatitis B Aldosterone synthesis and secretion 0 -0.572134387 0 kegg kegg NA NA no no no no up up Hepatitis B Aldosterone-regulated sodium reabsorption 0.608695652 0.483201581 0.524581725 kegg kegg NA NA no no no no no no Hepatitis B Alistipes -0.455026173 0 0 kegg Genus NA 0.0114 no no no no up no Hepatitis B alpha-Linolenic acid metabolism 0 0.580039526 0 kegg kegg NA NA no no no no no no Hepatitis B Alzheimer disease 0 -0.805335968 0 kegg kegg NA NA no no no no no no Hepatitis B Amoebiasis 0 0.646245059 0 kegg kegg NA NA no no no no no no Hepatitis B Amphetamine addiction 0 -0.68972332 0 kegg kegg NA NA no no no no no no Hepatitis B AMPK signaling pathway -0.460869565 0 0 kegg kegg NA NA no no no no no no Hepatitis B Amyotrophic lateral sclerosis 0 -0.825098814 -0.405405405 kegg kegg NA NA no no no no no no Hepatitis B Anaerostipes 0 0 -0.400314721 butyrate-producing kegg Genus NA 0.568 no no no no no no Hepatitis B Apelin signaling pathway 0 -0.76284585 0 kegg kegg NA NA no no no no no no Hepatitis B Apoptosis 0 0.70256917 0 kegg kegg NA NA no no no no no no Hepatitis B Apoptosis - multiple species 0 0.450592885 0 kegg kegg NA NA no no no no no no Hepatitis B Arachidonic acid metabolism -0.673913043 0 -0.435778636 kegg kegg NA NA no no no no no no Hepatitis B Arginine and proline metabolism 0 0.821146245 0 kegg kegg NA NA no no no no up no Hepatitis B Arginine biosynthesis 0 0.77173913 0 kegg kegg NA NA no no no no no no Hepatitis B Autophagy - animal 0.853043478 0.966403162 0.47979408 kegg kegg NA NA no no no no no no Hepatitis B Autophagy - other 0.694782609 0.617588933 0.485199485 kegg kegg NA NA no no no no no no Hepatitis B Axon guidance 0.410434783 0 0 kegg kegg NA NA no no no no up up Hepatitis B B cell receptor signaling pathway 0.554782609 0.843873518 0.706563707 kegg kegg NA NA no no no no no no Hepatitis B Bacterial invasion of epithelial cells -0.516521739 -0.683794466 -0.536422136 kegg kegg NA NA no no no no no no Hepatitis B beta-Alanine metabolism -0.466086957 0 -0.64967825 kegg kegg NA NA no no no no no no Hepatitis B Bifidobacterium 0 -0.42843123 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Hepatitis B Bile secretion 0 -0.41798419 0 kegg kegg NA NA no no no no no no Hepatitis B Biosynthesis of amino acids 0 0.480237154 0 kegg kegg NA NA no no no no no no Hepatitis B Biosynthesis of cofactors -0.707826087 -0.451581028 0 kegg kegg NA NA no no no no no no Hepatitis B Biosynthesis of unsaturated fatty acids 0 0 -0.611840412 kegg kegg NA NA no no no no no no Hepatitis B Butanoate metabolism -0.464347826 -0.686758893 -0.687258687 kegg kegg NA NA no no no no no no Hepatitis B C-type lectin receptor signaling pathway 0.84173913 0.877470356 0.882882883 kegg kegg NA NA no no no no no no Hepatitis B Calcium signaling pathway 0 -0.468379447 0 kegg kegg NA NA no no no no up up Hepatitis B cAMP signaling pathway 0 0.429841897 0.54980695 yes kegg kegg NA NA no no no no up up Hepatitis B Carbohydrate digestion and absorption 0.804347826 0.657114625 0.453281853 kegg kegg NA NA no no no no no no Hepatitis B Carbon metabolism -0.436521739 0 0 kegg kegg NA NA no no no no no no Hepatitis B Cardiac muscle contraction 0 -0.782608696 0 kegg kegg NA NA no no no no no up Hepatitis B Cell cycle 0 -0.436758893 0 kegg kegg NA NA no no no no no no Hepatitis B Cellular senescence 0 0.445652174 0 kegg kegg NA NA no no no no no no Hepatitis B cGMP-PKG signaling pathway 0.611304348 0.571146245 0 kegg kegg NA NA no no no no no no Hepatitis B Chagas disease 0.590434783 0.792490119 0.49009009 kegg kegg NA NA no no no no no no Hepatitis B Chemokine signaling pathway 0.436521739 0.522727273 0 kegg kegg NA NA no no no no no no Hepatitis B Cholinergic synapse 0.635652174 0 0.473101673 kegg kegg NA NA no no no no no no Hepatitis B Circadian entrainment -0.5 -0.738142292 0 kegg kegg NA NA no no no no up up Hepatitis B Circadian rhythm 0.506956522 0 0 kegg kegg NA NA no no no no no no Hepatitis B Citrate cycle (TCA cycle) -0.471304348 -0.71541502 0 kegg kegg NA NA no no no no no no Hepatitis B Collecting duct acid secretion 0 0 -0.405662806 kegg kegg NA NA no no no no no no Hepatitis B Collinsella 0 0 -0.446782362 kegg Genus NA 0.128 no no no no no no Hepatitis B Complement and coagulation cascades 0 0.480237154 0 kegg kegg NA NA no no no no no no Hepatitis B Cysteine and methionine metabolism 0 -0.70256917 -0.439124839 kegg kegg NA NA no no no no no no Hepatitis B Cytokine-cytokine receptor interaction 0 0 -0.476190476 kegg kegg NA NA no no no no no no Hepatitis B Cytosolic DNA-sensing pathway 0 0.508893281 0 kegg kegg NA NA no no no no no no Hepatitis B DNA replication 0 -0.683794466 0 kegg kegg NA NA no no no no no no Hepatitis B Dopaminergic synapse 0 -0.710474308 0 kegg kegg NA NA no no no no up no Hepatitis B Drug metabolism - cytochrome P450 0 -0.815217391 -0.498841699 kegg kegg NA NA no no no no no no Hepatitis B Drug metabolism - other enzymes -0.522608696 -0.849802372 0 kegg kegg NA NA no no no no no no Hepatitis B EGFR tyrosine kinase inhibitor resistance 0 -0.610671937 0 kegg kegg NA NA no no no no no no Hepatitis B Endocrine and other factor-regulated calcium reabsorption -0.433043478 -0.662055336 0 kegg kegg NA NA no no no no no no Hepatitis B Epithelial cell signaling in Helicobacter pylori infection 0.474782609 0.704545455 0.455598456 kegg kegg NA NA no no no no no no Hepatitis B ErbB signaling pathway 0.622608696 0.638339921 0.633204633 kegg kegg NA NA no no no no no no Hepatitis B Estrogen signaling pathway 0 -0.646245059 0 kegg kegg NA NA no no no no no no Hepatitis B Fatty acid biosynthesis 0.47826087 0.800395257 0 kegg kegg NA NA no no no no no no Hepatitis B Fatty acid degradation 0 0.640316206 0 kegg kegg NA NA no no no no no no Hepatitis B Fatty acid elongation -0.416521739 -0.428853755 -0.678507079 kegg kegg NA NA no no no no no no Hepatitis B Fatty acid metabolism 0 0.543478261 0 kegg kegg NA NA no no no no no no Hepatitis B Fc epsilon RI signaling pathway 0.515652174 0.802371542 0.501415701 kegg kegg NA NA no no no no no no Hepatitis B Fc gamma R-mediated phagocytosis 0 0.476284585 0 kegg kegg NA NA no no no no no no Hepatitis B Focal adhesion -0.565217391 -0.816205534 -0.425997426 kegg kegg NA NA no no no no up up Hepatitis B Folate biosynthesis 0 -0.428853755 0 kegg kegg NA NA no no no no no no Hepatitis B FoxO signaling pathway 0.659130435 0.755928854 0 kegg kegg NA NA no no no no no no Hepatitis B Fructose and mannose metabolism 0 0.557312253 0 kegg kegg NA NA no no no no no no Hepatitis B GABAergic synapse 0 0.609683794 0 kegg kegg NA NA no no no no up up Hepatitis B Galactose metabolism 0 0.601778656 0 kegg kegg NA NA no no no no no no Hepatitis B Gap junction -0.473043478 0 0 kegg kegg NA NA no no no no no no Hepatitis B Gastric acid secretion -0.687826087 -0.883399209 -0.404890605 kegg kegg NA NA no no no no no no Hepatitis B Glucagon signaling pathway 0 -0.687747036 0 kegg kegg NA NA no no no no no no Hepatitis B Glutathione metabolism -0.713043478 -0.691699605 -0.462290862 kegg kegg NA NA no no no no no no Hepatitis B Glycerolipid metabolism 0 0.606719368 0 kegg kegg NA NA no no no no no up Hepatitis B Glycerophospholipid metabolism 0 0.5256917 0 kegg kegg NA NA no no no no no up Hepatitis B "Glycine, serine and threonine metabolism" -0.7 0 0 kegg kegg NA NA no no no no up no Hepatitis B Glycolysis / Gluconeogenesis -0.422608696 -0.696640316 -0.546718147 kegg kegg NA NA no no no no no no Hepatitis B Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.416521739 0.871541502 0.41956242 kegg kegg NA NA no no no no no no Hepatitis B Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.605217391 0 0 kegg kegg NA NA no no no no no no Hepatitis B Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.449604743 0.430888031 kegg kegg NA NA no no no no no no Hepatitis B Glyoxylate and dicarboxylate metabolism 0 0.773715415 0 kegg kegg NA NA no no no no no no Hepatitis B GnRH secretion 0.639130435 0.660079051 0.508622909 kegg kegg NA NA no no no no up up Hepatitis B "Growth hormone synthesis, secretion and action" 0 0.453557312 0.594851995 kegg kegg NA NA no no no no no no Hepatitis B Hematopoietic cell lineage 0 0 -0.467953668 kegg kegg NA NA no no no no no no Hepatitis B Hepatitis C 0.766956522 0.634387352 0.874646075 kegg kegg NA NA no no no no no no Hepatitis B HIF-1 signaling pathway 0 -0.657114625 0 kegg kegg NA NA no no no no no no Hepatitis B Hippo signaling pathway -0.68173913 -0.849802372 -0.427027027 kegg kegg NA NA no no no no no no Hepatitis B Hippo signaling pathway - multiple species 0.529565217 0.754940711 0 kegg kegg NA NA no no no no no no Hepatitis B Huntington disease 0 -0.805335968 -0.401544402 kegg kegg NA NA no no no no no no Hepatitis B IL-17 signaling pathway 0.640869565 0.533596838 0 kegg kegg NA NA no no no no no no Hepatitis B Inflammatory mediator regulation of TRP channels 0 -0.758893281 0 kegg kegg NA NA no no no no no no Hepatitis B Inositol phosphate metabolism 0 0.500988142 0 kegg kegg NA NA no no no no no no Hepatitis B Insulin resistance 0.805217391 0.876482213 0.831917632 kegg kegg NA NA no no no no no no Hepatitis B Insulin signaling pathway 0 -0.684782609 0 kegg kegg NA NA no no no no no no Hepatitis B JAK-STAT signaling pathway 0.415652174 0.867588933 0 kegg kegg NA NA no no no no no no Hepatitis B Lachnospira 0 -0.529775158 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Hepatitis B Leukocyte transendothelial migration 0 -0.420948617 0 kegg kegg NA NA no no no no no no Hepatitis B Long-term potentiation 0 -0.498023715 0 kegg kegg NA NA no no no no no up Hepatitis B Longevity regulating pathway - multiple species 0 0 -0.507850708 kegg kegg NA NA no no no no no no Hepatitis B Malaria -0.447826087 0 0 kegg kegg NA NA no no no no no no Hepatitis B MAPK signaling pathway 0.523478261 0.546442688 0 kegg kegg NA NA no no no no no no Hepatitis B Melanogenesis -0.446086957 -0.749011858 0 kegg kegg NA NA no no no no no no Hepatitis B Metabolism of xenobiotics by cytochrome P450 -0.437391304 -0.81027668 -0.538996139 kegg kegg NA NA no no no no no no Hepatitis B Mismatch repair 0 -0.575098814 -0.581209781 kegg kegg NA NA no no no no no no Hepatitis B Mitophagy - animal 0 -0.493083004 0 kegg kegg NA NA no no no no no no Hepatitis B Morphine addiction 0 -0.503952569 0 kegg kegg NA NA no no no no up up Hepatitis B mRNA surveillance pathway 0 -0.454545455 0 kegg kegg NA NA no no no no no no Hepatitis B mTOR signaling pathway 0 -0.586956522 0 kegg kegg NA NA no no no no no no Hepatitis B Mucin type O-glycan biosynthesis 0 0.432806324 0 kegg kegg NA NA no no no no no no Hepatitis B N-Glycan biosynthesis 0 -0.687747036 0 kegg kegg NA NA no no no no no no Hepatitis B Neurotrophin signaling pathway 0.667826087 0.716403162 0.787129987 kegg kegg NA NA no no no no no no Hepatitis B NF-kappa B signaling pathway 0.768695652 0.960474308 0.865122265 kegg kegg NA NA no no no no no no Hepatitis B Nicotinate and nicotinamide metabolism 0.437391304 0.76284585 0 kegg kegg NA NA no no no no no no Hepatitis B Nicotine addiction 0 0 0.471557272 kegg kegg NA NA no no no no up up Hepatitis B Nitrogen metabolism 0 0.719367589 0 kegg kegg NA NA no no no no no no Hepatitis B NOD-like receptor signaling pathway 0.519130435 0.895256917 0 kegg kegg NA NA no no no no no no Hepatitis B Non-alcoholic fatty liver disease 0 -0.710474308 0 kegg kegg NA NA no no no no no no Hepatitis B Non-homologous end-joining 0 -0.511857708 -0.624195624 kegg kegg NA NA no no no no no no Hepatitis B Notch signaling pathway 0.408695652 0.504940711 0 kegg kegg NA NA no no no no no no Hepatitis B Nucleotide excision repair 0 -0.565217391 -0.485714286 kegg kegg NA NA no no no no no no Hepatitis B One carbon pool by folate 0 -0.593873518 0 kegg kegg NA NA no no no no no no Hepatitis B Oocyte meiosis 0 -0.661067194 0 kegg kegg NA NA no no no no no no Hepatitis B Oscillospira 0 0.414031621 0 LPS-producing kegg Genus NA 0.62 no no no no no no Hepatitis B Osteoclast differentiation 0.492173913 0.778656126 0.47027027 kegg kegg NA NA no no no no no no Hepatitis B Other glycan degradation 0 0.552371542 0 kegg kegg NA NA no no no no no no Hepatitis B Ovarian steroidogenesis -0.508695652 0 0 kegg kegg NA NA no no no no up up Hepatitis B Oxidative phosphorylation 0 -0.804347826 0 kegg kegg NA NA no no no no no no Hepatitis B Oxytocin signaling pathway -0.586086957 -0.583003953 -0.468468468 kegg kegg NA NA no no no no no no Hepatitis B p53 signaling pathway 0.506956522 0 0 kegg kegg NA NA no no no no no no Hepatitis B Pancreatic secretion 0 -0.662055336 0 kegg kegg NA NA no no no no no no Hepatitis B Pantothenate and CoA biosynthesis 0.508695652 0.695652174 0 kegg kegg NA NA no no no no no dn Hepatitis B "Parathyroid hormone synthesis, secretion and action" 0 -0.51284585 0 kegg kegg NA NA no no no no no no Hepatitis B Parkinson disease 0 -0.729249012 0 kegg kegg NA NA no no no no no no Hepatitis B Pathways of neurodegeneration - multiple diseases 0 -0.713438735 0 kegg kegg NA NA no no no no no no Hepatitis B Pentose and glucuronate interconversions -0.509565217 -0.714426877 0 kegg kegg NA NA no no no no no no Hepatitis B Peroxisome 0 0.654150198 0 kegg kegg NA NA no no no no no no Hepatitis B Pertussis 0 0.537549407 0 kegg kegg NA NA no no no no no dn Hepatitis B Phenylalanine metabolism -0.71826087 -0.685770751 -0.484427284 kegg kegg NA NA no no no no no no Hepatitis B Phospholipase D signaling pathway 0 0.713438735 0.516602317 kegg kegg NA NA no no no no up up Hepatitis B Phototransduction 0 -0.734189723 -0.501930502 kegg kegg NA NA no no no no no no Hepatitis B PI3K-Akt signaling pathway 0.408695652 0 0 yes kegg kegg NA NA no no no no up up Hepatitis B Platelet activation -0.668695652 -0.753952569 0 kegg kegg NA NA no no no no no no Hepatitis B Platinum drug resistance 0.45826087 0 0 kegg kegg NA NA no no no no no no Hepatitis B Porphyrin and chlorophyll metabolism -0.642608696 0 0 kegg kegg NA NA no no no no no no Hepatitis B PPAR signaling pathway 0 0.735177866 0 kegg kegg NA NA no no no no no no Hepatitis B Primary bile acid biosynthesis 0 -0.464426877 -0.523037323 kegg kegg NA NA no no no no no no Hepatitis B Prion disease 0 -0.840909091 0 kegg kegg NA NA no no no no no no Hepatitis B Progesterone-mediated oocyte maturation 0.68173913 0 0 kegg kegg NA NA no no no no no no Hepatitis B Prolactin signaling pathway 0.607826087 0.777667984 0.718404118 kegg kegg NA NA no no no no no no Hepatitis B Propanoate metabolism 0 -0.675889328 -0.478507079 kegg kegg NA NA no no no no no no Hepatitis B Proteasome 0 -0.696640316 0 kegg kegg NA NA no no no no no no Hepatitis B Protein digestion and absorption 0 0.672924901 0 yes kegg kegg NA NA no no no no up up Hepatitis B Protein export 0 -0.764822134 0 kegg kegg NA NA no no no no no no Hepatitis B Protein processing in endoplasmic reticulum 0 -0.643280632 0 kegg kegg NA NA no no no no no no Hepatitis B Proximal tubule bicarbonate reclamation 0 -0.71541502 0 kegg kegg NA NA no no no no no no Hepatitis B Purine metabolism -0.503478261 0 0 kegg kegg NA NA no no no no no no Hepatitis B Pyrimidine metabolism 0 -0.643280632 0 kegg kegg NA NA no no no no no no Hepatitis B Pyruvate metabolism 0 -0.756916996 -0.628314028 kegg kegg NA NA no no no no no no Hepatitis B Rap1 signaling pathway -0.424347826 -0.588932806 0 kegg kegg NA NA no no no no no no Hepatitis B Ras signaling pathway 0 -0.699604743 0 yes kegg kegg NA NA no no no no up up Hepatitis B Regulation of actin cytoskeleton -0.515652174 -0.657114625 -0.629343629 kegg kegg NA NA no no no no no no Hepatitis B Relaxin signaling pathway 0 0.559288538 0.547747748 kegg kegg NA NA no no no no no no Hepatitis B Renin secretion -0.646086957 -0.849802372 0 kegg kegg NA NA no no no no no no Hepatitis B Renin-angiotensin system 0 0.495059289 0 kegg kegg NA NA no no no no no no Hepatitis B Retinol metabolism 0 -0.421936759 -0.400514801 kegg kegg NA NA no no no no no no Hepatitis B Retrograde endocannabinoid signaling 0 -0.849802372 0 kegg kegg NA NA no no no no no up Hepatitis B Ribosome 0 -0.755928854 0 kegg kegg NA NA no no no no no no Hepatitis B RIG-I-like receptor signaling pathway 0.900869565 0.955533597 0.877220077 kegg kegg NA NA no no no no no no Hepatitis B RNA degradation 0 -0.625494071 0 kegg kegg NA NA no no no no no no Hepatitis B RNA polymerase 0 -0.540513834 0 kegg kegg NA NA no no no no no no Hepatitis B RNA transport 0 -0.522727273 0 kegg kegg NA NA no no no no no no Hepatitis B Roseburia -0.504347826 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no Hepatitis B Salivary secretion -0.502608696 -0.545454545 0 kegg kegg NA NA no no no no no no Hepatitis B Selenocompound metabolism 0.420869565 0 0 kegg kegg NA NA no no no no no no Hepatitis B Shigellosis 0 -0.509881423 0 kegg kegg NA NA no no no no no no Hepatitis B Signaling pathways regulating pluripotency of stem cells 0.573043478 0 0.487258687 kegg kegg NA NA no no no no no no Hepatitis B SNARE interactions in vesicular transport 0 0.738142292 0 kegg kegg NA NA no no no no no no Hepatitis B Sphingolipid signaling pathway 0.595652174 0.437747036 0 kegg kegg NA NA no no no no no no Hepatitis B Spinocerebellar ataxia 0.60173913 0 0 kegg kegg NA NA no no no no no no Hepatitis B Spliceosome 0.451304348 0 0 kegg kegg NA NA no no no no no no Hepatitis B Starch and sucrose metabolism 0 0.717391304 0 kegg kegg NA NA no no no no no no Hepatitis B Steroid biosynthesis 0 -0.556324111 -0.47979408 kegg kegg NA NA no no no no no no Hepatitis B Steroid hormone biosynthesis -0.463478261 -0.517786561 0 kegg kegg NA NA no no no no no no Hepatitis B Sulfur metabolism -0.64 0 0 kegg kegg NA NA no no no no no no Hepatitis B Synthesis and degradation of ketone bodies 0 -0.486166008 -0.434749035 kegg kegg NA NA no no no no no no Hepatitis B T cell receptor signaling pathway 0.69826087 0.720355731 0 kegg kegg NA NA no no no no no no Hepatitis B Taste transduction 0 -0.43972332 0 kegg kegg NA NA no no no no no up Hepatitis B Taurine and hypotaurine metabolism 0.453913043 0.625494071 0.406692407 kegg kegg NA NA no no no no no no Hepatitis B TGF-beta signaling pathway 0 -0.706521739 0 kegg kegg NA NA no no no no no no Hepatitis B Th1 and Th2 cell differentiation 0 0.440711462 0 kegg kegg NA NA no no no no no no Hepatitis B Th17 cell differentiation 0 0.506916996 0 kegg kegg NA NA no no no no no no Hepatitis B Thermogenesis 0 -0.847826087 -0.42007722 kegg kegg NA NA no no no no no no Hepatitis B Thiamine metabolism 0 -0.53458498 0 kegg kegg NA NA no no no no no no Hepatitis B Thyroid hormone signaling pathway 0 -0.730237154 0 kegg kegg NA NA no no no no no no Hepatitis B Thyroid hormone synthesis -0.573043478 0 0 kegg kegg NA NA no no no no no no Hepatitis B Tight junction -0.645217391 -0.763833992 -0.671299871 kegg kegg NA NA no no no no no no Hepatitis B TNF signaling pathway 0.711304348 0.880434783 0.757528958 kegg kegg NA NA no no no no no no Hepatitis B Toll-like receptor signaling pathway 0.744347826 0.862648221 0.621879022 yes kegg kegg NA NA no no no no no no Hepatitis B Toxoplasmosis 0 0.454545455 0 kegg kegg NA NA no no no no no no Hepatitis B Tryptophan metabolism -0.465217391 -0.556324111 -0.462290862 kegg kegg NA NA no no no no up no Hepatitis B Type II diabetes mellitus 0.74 0.830039526 0.595109395 kegg kegg NA NA no no no no no no Hepatitis B Tyrosine metabolism -0.620869565 -0.711462451 -0.805662806 kegg kegg NA NA no no no no no no Hepatitis B Ubiquinone and other terpenoid-quinone biosynthesis -0.414782609 -0.501976285 -0.464092664 kegg kegg NA NA no no no no no no Hepatitis B Ubiquitin mediated proteolysis 0 -0.559288538 0 kegg kegg NA NA no no no no no no Hepatitis B "Valine, leucine and isoleucine degradation" 0 -0.621541502 -0.594594595 kegg kegg NA NA no no no no no no Hepatitis B Various types of N-glycan biosynthesis 0 -0.494071146 0 kegg kegg NA NA no no no no no no Hepatitis B Vascular smooth muscle contraction 0 -0.820158103 0 kegg kegg NA NA no no no no no no Hepatitis B Vasopressin-regulated water reabsorption 0 -0.710474308 0 kegg kegg NA NA no no no no no no Hepatitis B VEGF signaling pathway 0.66 0.56916996 0.474646075 kegg kegg NA NA no no no no no no Hepatitis B Vibrio cholerae infection -0.632173913 -0.785573123 0 kegg kegg NA NA no no no no no no Hepatitis B Wnt signaling pathway 0 -0.663043478 0 kegg kegg NA NA no no no no no no Hepatitis C 2-Oxocarboxylic acid metabolism -0.622608696 0 -0.406949807 kegg kegg NA NA no no no no no no Hepatitis C Adherens junction 0 -0.448616601 0 kegg kegg NA NA no no no no no no Hepatitis C Adipocytokine signaling pathway 0 0.65513834 0 kegg kegg NA NA no no no no no no Hepatitis C African trypanosomiasis 0.456521739 0 0 kegg kegg NA NA no no no no no no Hepatitis C AGE-RAGE signaling pathway in diabetic complications 0 0 0.504247104 kegg kegg NA NA no no no no no no Hepatitis C "Alanine, aspartate and glutamate metabolism" 0 0.423913043 0 kegg kegg NA NA no no no no no no Hepatitis C Aldosterone-regulated sodium reabsorption 0.593043478 0.420948617 0 kegg kegg NA NA no no no no no no Hepatitis C Amino sugar and nucleotide sugar metabolism 0 -0.414031621 -0.51969112 kegg kegg NA NA no no no no no no Hepatitis C Amphetamine addiction 0 -0.53458498 0 kegg kegg NA NA no no no no no no Hepatitis C AMPK signaling pathway -0.470434783 0 0 kegg kegg NA NA no no no no no no Hepatitis C Antifolate resistance -0.408695652 -0.544466403 0 kegg kegg NA NA no no no no no no Hepatitis C Apoptosis 0 0.586956522 0 kegg kegg NA NA no no no no no no Hepatitis C Arachidonic acid metabolism -0.503478261 0 -0.428571429 kegg kegg NA NA no no no no no no Hepatitis C Arginine and proline metabolism 0 0.43083004 0 kegg kegg NA NA no no no no up no Hepatitis C Arginine biosynthesis 0 0.42687747 0 kegg kegg NA NA no no no no no no Hepatitis C Autophagy - animal 0.562608696 0.630434783 0 kegg kegg NA NA no no no no no no Hepatitis C Autophagy - other 0.56173913 0.535573123 0.406177606 kegg kegg NA NA no no no no no no Hepatitis C Axon guidance 0.606086957 0 0 kegg kegg NA NA no no no no up up Hepatitis C B cell receptor signaling pathway 0.433913043 0.709486166 0.544658945 kegg kegg NA NA no no no no no no Hepatitis C Bacterial invasion of epithelial cells 0 0 -0.51969112 kegg kegg NA NA no no no no no no Hepatitis C beta-Alanine metabolism -0.567826087 -0.494071146 -0.652509653 kegg kegg NA NA no no no no no no Hepatitis C Bile secretion 0 -0.433794466 0 kegg kegg NA NA no no no no no no Hepatitis C Biosynthesis of cofactors -0.671304348 -0.488142292 0 kegg kegg NA NA no no no no no no Hepatitis C Biosynthesis of unsaturated fatty acids 0 -0.565217391 -0.61003861 kegg kegg NA NA no no no no no no Hepatitis C Butanoate metabolism -0.566086957 -0.536561265 -0.658687259 kegg kegg NA NA no no no no no no Hepatitis C C-type lectin receptor signaling pathway 0.806086957 0.788537549 0.785328185 kegg kegg NA NA no no no no no no Hepatitis C Calcium signaling pathway 0 0 0.460746461 kegg kegg NA NA no no no no up up Hepatitis C cAMP signaling pathway 0.6 0.585968379 0.643758044 yes kegg kegg NA NA no no no no up up Hepatitis C Carbohydrate digestion and absorption 0.609565217 0 0 kegg kegg NA NA no no no no no no Hepatitis C Carbon metabolism -0.446086957 0 -0.463835264 kegg kegg NA NA no no no no no no Hepatitis C Cellular senescence 0 0.5 0 kegg kegg NA NA no no no no no no Hepatitis C cGMP-PKG signaling pathway 0.529565217 0 0 kegg kegg NA NA no no no no no no Hepatitis C Chagas disease 0.530434783 0.649209486 0.561389961 kegg kegg NA NA no no no no no no Hepatitis C Chemokine signaling pathway 0.477391304 0.414031621 0 kegg kegg NA NA no no no no no no Hepatitis C Cholesterol metabolism 0 0.427865613 0 yes kegg kegg NA NA no no no no no up Hepatitis C Cholinergic synapse 0.552173913 0 0 kegg kegg NA NA no no no no no no Hepatitis C Circadian entrainment 0 -0.796442688 0 kegg kegg NA NA no no no no up up Hepatitis C Circadian rhythm 0.49826087 0 0 kegg kegg NA NA no no no no no no Hepatitis C Citrate cycle (TCA cycle) -0.466956522 -0.502964427 -0.421879022 kegg kegg NA NA no no no no no no Hepatitis C Cocaine addiction 0 0 0.428571429 kegg kegg NA NA no no no no no no Hepatitis C Collecting duct acid secretion 0 -0.517786561 -0.425482625 kegg kegg NA NA no no no no no no Hepatitis C Cushing syndrome 0 0 0.438610039 kegg kegg NA NA no no no no no up Hepatitis C Cysteine and methionine metabolism 0 -0.443675889 0 kegg kegg NA NA no no no no no no Hepatitis C Cytosolic DNA-sensing pathway 0 0.875494071 0.461776062 kegg kegg NA NA no no no no no no Hepatitis C DNA replication 0 -0.566205534 0 kegg kegg NA NA no no no no no no Hepatitis C Dopaminergic synapse 0 -0.636363636 0 kegg kegg NA NA no no no no up no Hepatitis C Drug metabolism - cytochrome P450 0 -0.576086957 -0.581209781 kegg kegg NA NA no no no no no no Hepatitis C Drug metabolism - other enzymes -0.432173913 -0.494071146 0 kegg kegg NA NA no no no no no no Hepatitis C Epithelial cell signaling in Helicobacter pylori infection 0 0.633399209 0 kegg kegg NA NA no no no no no no Hepatitis C ErbB signaling pathway 0.413913043 0 0.487001287 kegg kegg NA NA no no no no no no Hepatitis C Estrogen signaling pathway 0 -0.706521739 0 kegg kegg NA NA no no no no no no Hepatitis C Fatty acid elongation 0 -0.429841897 -0.662290862 kegg kegg NA NA no no no no no no Hepatitis C Fatty acid metabolism 0 0 -0.409009009 kegg kegg NA NA no no no no no no Hepatitis C Fc epsilon RI signaling pathway 0.405217391 0.485177866 0 kegg kegg NA NA no no no no no no Hepatitis C Focal adhesion 0 -0.520750988 0 kegg kegg NA NA no no no no up up Hepatitis C Gastric acid secretion 0 -0.57312253 0 kegg kegg NA NA no no no no no no Hepatitis C Glucagon signaling pathway 0 -0.445652174 0 kegg kegg NA NA no no no no no no Hepatitis C Glutathione metabolism -0.450434783 -0.415019763 0 kegg kegg NA NA no no no no no no Hepatitis C "Glycine, serine and threonine metabolism" -0.591304348 0 0 kegg kegg NA NA no no no no up no Hepatitis C Glycolysis / Gluconeogenesis -0.443478261 0 -0.593564994 kegg kegg NA NA no no no no no no Hepatitis C Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.415019763 0 kegg kegg NA NA no no no no no no Hepatitis C Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.60173913 0 0 kegg kegg NA NA no no no no no no Hepatitis C Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.422924901 0 kegg kegg NA NA no no no no no no Hepatitis C Glyoxylate and dicarboxylate metabolism 0 0.461462451 0 kegg kegg NA NA no no no no no no Hepatitis C GnRH secretion 0.451304348 0.428853755 0 kegg kegg NA NA no no no no up up Hepatitis C "Growth hormone synthesis, secretion and action" 0 0 0.620592021 kegg kegg NA NA no no no no no no Hepatitis C Hematopoietic cell lineage -0.532173913 0 -0.44041184 kegg kegg NA NA no no no no no no Hepatitis C Hippo signaling pathway 0 -0.454545455 0 kegg kegg NA NA no no no no no no Hepatitis C Hippo signaling pathway - multiple species 0.405217391 0 0 kegg kegg NA NA no no no no no no Hepatitis C Histidine metabolism 0 0 -0.465379665 kegg kegg NA NA no no no no no no Hepatitis C IL-17 signaling pathway 0.548695652 0 0 kegg kegg NA NA no no no no no no Hepatitis C Inflammatory mediator regulation of TRP channels 0 -0.513833992 0 kegg kegg NA NA no no no no no no Hepatitis C Insulin resistance 0.643478261 0.712450593 0.714028314 kegg kegg NA NA no no no no no no Hepatitis C JAK-STAT signaling pathway 0 0.420948617 0 kegg kegg NA NA no no no no no no Hepatitis C Long-term potentiation 0.469565217 0 0 kegg kegg NA NA no no no no no up Hepatitis C Malaria -0.459130435 0.463438735 0 kegg kegg NA NA no no no no no no Hepatitis C Maturity onset diabetes of the young 0 -0.48715415 0 kegg kegg NA NA no no no no up no Hepatitis C Melanogenesis 0 -0.416007905 0 kegg kegg NA NA no no no no no no Hepatitis C Metabolism of xenobiotics by cytochrome P450 0 -0.597826087 -0.612097812 kegg kegg NA NA no no no no no no Hepatitis C Mismatch repair 0 -0.598814229 -0.487516088 kegg kegg NA NA no no no no no no Hepatitis C Morphine addiction 0 -0.479249012 0 kegg kegg NA NA no no no no up up Hepatitis C Neurotrophin signaling pathway 0.807826087 0.907114625 0.688545689 kegg kegg NA NA no no no no no no Hepatitis C NF-kappa B signaling pathway 0 0.654150198 0.766023166 kegg kegg NA NA no no no no no no Hepatitis C Nicotine addiction 0 0 0.446332046 kegg kegg NA NA no no no no up up Hepatitis C NOD-like receptor signaling pathway 0 0.674901186 0.419047619 kegg kegg NA NA no no no no no no Hepatitis C Non-homologous end-joining -0.446086957 -0.48715415 -0.533590734 kegg kegg NA NA no no no no no no Hepatitis C Nucleotide excision repair 0 -0.60770751 -0.408494208 kegg kegg NA NA no no no no no no Hepatitis C One carbon pool by folate 0 -0.709486166 0 kegg kegg NA NA no no no no no no Hepatitis C Osteoclast differentiation 0 0.5 0 kegg kegg NA NA no no no no no no Hepatitis C Oxytocin signaling pathway 0 -0.447628458 -0.43989704 kegg kegg NA NA no no no no no no Hepatitis C Pancreatic secretion 0 -0.419960474 0 kegg kegg NA NA no no no no no no Hepatitis C Pentose and glucuronate interconversions 0 -0.440711462 0 kegg kegg NA NA no no no no no no Hepatitis C Phenylalanine metabolism -0.650434783 -0.588932806 -0.424710425 kegg kegg NA NA no no no no no no Hepatitis C Phospholipase D signaling pathway 0 0 0.402316602 kegg kegg NA NA no no no no up up Hepatitis C Phototransduction 0 -0.443675889 -0.446074646 kegg kegg NA NA no no no no no no Hepatitis C Platelet activation 0 -0.549407115 0 kegg kegg NA NA no no no no no no Hepatitis C Porphyrin and chlorophyll metabolism -0.575652174 0 0 kegg kegg NA NA no no no no no no Hepatitis C PPAR signaling pathway 0 0.666007905 0 kegg kegg NA NA no no no no no no Hepatitis C Primary bile acid biosynthesis -0.407826087 -0.470355731 -0.58018018 kegg kegg NA NA no no no no no no Hepatitis C Progesterone-mediated oocyte maturation 0.494782609 0 0 kegg kegg NA NA no no no no no no Hepatitis C Prolactin signaling pathway 0.5 0.48715415 0.66048906 kegg kegg NA NA no no no no no no Hepatitis C Propanoate metabolism 0 -0.423913043 0 kegg kegg NA NA no no no no no no Hepatitis C Proximal tubule bicarbonate reclamation 0 -0.522727273 0 kegg kegg NA NA no no no no no no Hepatitis C Purine metabolism -0.593913043 0 0 kegg kegg NA NA no no no no no no Hepatitis C Pyrimidine metabolism 0 -0.714426877 0 kegg kegg NA NA no no no no no no Hepatitis C Pyruvate metabolism 0 -0.466403162 -0.467696268 kegg kegg NA NA no no no no no no Hepatitis C Ras signaling pathway 0 -0.509881423 0 yes kegg kegg NA NA no no no no up up Hepatitis C Regulation of actin cytoskeleton 0 -0.489130435 -0.549292149 kegg kegg NA NA no no no no no no Hepatitis C Relaxin signaling pathway 0.479130435 0.559288538 0.578893179 kegg kegg NA NA no no no no no no Hepatitis C Renin secretion 0 -0.598814229 0 kegg kegg NA NA no no no no no no Hepatitis C Retinol metabolism 0 -0.723320158 -0.525353925 kegg kegg NA NA no no no no no no Hepatitis C RIG-I-like receptor signaling pathway 0.75826087 0.739130435 0.846846847 kegg kegg NA NA no no no no no no Hepatitis C Salivary secretion 0 -0.636363636 0 kegg kegg NA NA no no no no no no Hepatitis C Sarcina 0 0.444554224 0 kegg Genus NA 0.0703 no no no no no no Hepatitis C Signaling pathways regulating pluripotency of stem cells 0.5 0 0.468211068 kegg kegg NA NA no no no no no no Hepatitis C Sphingolipid signaling pathway 0.636521739 0.606719368 0 kegg kegg NA NA no no no no no no Hepatitis C Spinocerebellar ataxia 0.46173913 0 0 kegg kegg NA NA no no no no no no Hepatitis C Steroid biosynthesis 0 -0.663043478 -0.538223938 kegg kegg NA NA no no no no no no Hepatitis C Steroid hormone biosynthesis 0 -0.755928854 0 kegg kegg NA NA no no no no no no Hepatitis C Sulfur metabolism -0.556521739 0 0 kegg kegg NA NA no no no no no no Hepatitis C Synthesis and degradation of ketone bodies 0 -0.597826087 -0.464350064 kegg kegg NA NA no no no no no no Hepatitis C T cell receptor signaling pathway 0.737391304 0.729249012 0.459459459 kegg kegg NA NA no no no no no no Hepatitis C Taste transduction 0 -0.557312253 0 kegg kegg NA NA no no no no no up Hepatitis C Th1 and Th2 cell differentiation 0 0.546442688 0 kegg kegg NA NA no no no no no no Hepatitis C Th17 cell differentiation 0 0.662055336 0 kegg kegg NA NA no no no no no no Hepatitis C Tight junction 0 -0.429841897 -0.66975547 kegg kegg NA NA no no no no no no Hepatitis C TNF signaling pathway 0.674782609 0.793478261 0.699099099 kegg kegg NA NA no no no no no no Hepatitis C Toll-like receptor signaling pathway 0.592173913 0.707509881 0.555984556 yes kegg kegg NA NA no no no no no no Hepatitis C Tryptophan metabolism -0.593043478 -0.585968379 -0.526383526 kegg kegg NA NA no no no no up no Hepatitis C Type II diabetes mellitus 0.586956522 0.446640316 0 kegg kegg NA NA no no no no no no Hepatitis C Tyrosine metabolism -0.609565217 -0.76284585 -0.723809524 kegg kegg NA NA no no no no no no Hepatitis C Ubiquinone and other terpenoid-quinone biosynthesis -0.467826087 -0.640316206 -0.413642214 kegg kegg NA NA no no no no no no Hepatitis C "Valine, leucine and isoleucine degradation" -0.49826087 -0.619565217 -0.612612613 kegg kegg NA NA no no no no no no Hepatitis C Vascular smooth muscle contraction 0 -0.4743083 0 kegg kegg NA NA no no no no no no Hepatitis C Vasopressin-regulated water reabsorption 0 -0.500988142 0 kegg kegg NA NA no no no no no no Hepatitis C VEGF signaling pathway 0.596521739 0.460474308 0 kegg kegg NA NA no no no no no no Hepatitis C Vibrio cholerae infection 0 -0.546442688 0 kegg kegg NA NA no no no no no no Hepatitis C Vitamin digestion and absorption 0 -0.445652174 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma 2-Oxocarboxylic acid metabolism 0 0.470355731 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma ABC transporters 0 -0.496047431 0 kegg kegg NA NA no no no no up up Hepatocellular carcinoma Adherens junction 0.920869565 0.936758893 0.917889318 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Adipocytokine signaling pathway 0 -0.524703557 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Adrenergic signaling in cardiomyocytes 0 0.451581028 0 kegg kegg NA NA no no no no no up Hepatocellular carcinoma AGE-RAGE signaling pathway in diabetic complications 0 -0.522727273 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma "Alanine, aspartate and glutamate metabolism" 0 -0.706521739 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma alpha-Linolenic acid metabolism 0 -0.489130435 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Alzheimer disease 0 0.600790514 0.514800515 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Amyotrophic lateral sclerosis 0 0.626482213 0.642471042 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Apelin signaling pathway -0.525217391 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Apoptosis 0.443478261 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Apoptosis - multiple species -0.572173913 -0.531620553 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Arginine and proline metabolism 0 -0.608695652 -0.43037323 kegg kegg NA NA no no no no up no Hepatocellular carcinoma Arginine biosynthesis 0 -0.665019763 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Ascorbate and aldarate metabolism 0 0.418972332 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Autophagy - animal -0.602608696 -0.781620553 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Autophagy - other -0.827826087 -0.690711462 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma B cell receptor signaling pathway 0 -0.43083004 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Bacterial invasion of epithelial cells 0.836521739 0.838932806 0.830888031 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Basal transcription factors -0.687826087 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Base excision repair -0.595652174 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Bifidobacterium 0 0.471026704 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Hepatocellular carcinoma Bile secretion 0 0.437747036 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Bladder cancer 0 -0.495059289 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Breast cancer 0 -0.548418972 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Butyricicoccus -0.450342006 0 0 butyrate-producing kegg Genus NA 0.852 no no no no no no Hepatocellular carcinoma C-type lectin receptor signaling pathway 0 -0.522727273 -0.434491634 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Calcium signaling pathway 0 0.535573123 0 kegg kegg NA NA no no no no up up Hepatocellular carcinoma Cardiac muscle contraction 0 0.647233202 0.616216216 kegg kegg NA NA no no no no no up Hepatocellular carcinoma Chagas disease 0 -0.480237154 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Circadian entrainment 0 0.566205534 0 kegg kegg NA NA no no no no up up Hepatocellular carcinoma Circadian rhythm -0.487826087 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Coronavirus disease - COVID-19 0 0.446640316 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Cytokine-cytokine receptor interaction 0 0 0.48005148 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Dopaminergic synapse 0 0.476284585 0 kegg kegg NA NA no no no no up no Hepatocellular carcinoma Drug metabolism - cytochrome P450 0 0.544466403 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Drug metabolism - other enzymes 0 0.660079051 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma EGFR tyrosine kinase inhibitor resistance -0.457391304 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Endocrine and other factor-regulated calcium reabsorption 0 0.496047431 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Fatty acid biosynthesis 0 -0.601778656 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Fatty acid degradation 0 -0.617588933 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Fatty acid metabolism 0 -0.606719368 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Focal adhesion 0.846086957 0.858695652 0.846589447 kegg kegg NA NA no no no no up up Hepatocellular carcinoma Folate biosynthesis 0 0.541501976 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma FoxO signaling pathway 0 -0.679841897 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma GABAergic synapse 0 -0.591897233 0 kegg kegg NA NA no no no no up up Hepatocellular carcinoma Gastric acid secretion 0.851304348 0.907114625 0.813384813 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Glycerolipid metabolism 0 -0.483201581 0 kegg kegg NA NA no no no no no up Hepatocellular carcinoma Glycerophospholipid metabolism 0 -0.538537549 0 kegg kegg NA NA no no no no no up Hepatocellular carcinoma Glycolysis / Gluconeogenesis 0 0.459486166 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.511857708 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.470434783 0.441699605 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Glyoxylate and dicarboxylate metabolism 0 -0.660079051 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Hematopoietic cell lineage 0 0 0.515572716 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Hepatitis B -0.459130435 -0.756916996 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Hepatitis C 0 -0.432806324 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma HIF-1 signaling pathway -0.594782609 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Hippo signaling pathway 0.868695652 0.920948617 0.92046332 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Hippo signaling pathway - multiple species 0 -0.522727273 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Homologous recombination 0 -0.423913043 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Huntington disease 0 0.598814229 0.537194337 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Inflammatory mediator regulation of TRP channels 0 0.541501976 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Influenza A 0.622608696 0 0.605148005 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Inositol phosphate metabolism 0 -0.45256917 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Insulin resistance -0.502608696 -0.53458498 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Insulin signaling pathway -0.540869565 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Intestinal immune network for IgA production 0 0.424901186 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma JAK-STAT signaling pathway 0 -0.627470356 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Lachnospira 0 0.576723516 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Hepatocellular carcinoma Legionellosis -0.42 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Leukocyte transendothelial migration 0.768695652 0.608695652 0.541827542 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Long-term potentiation -0.446956522 0 0 kegg kegg NA NA no no no no no up Hepatocellular carcinoma Longevity regulating pathway 0 -0.424901186 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Malaria 0 0 -0.482625483 kegg kegg NA NA no no no no no no Hepatocellular carcinoma MAPK signaling pathway 0 -0.588932806 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Melanogenesis 0 0.54743083 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Melanoma 0 -0.514822134 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Metabolism of xenobiotics by cytochrome P450 0 0.565217391 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma MicroRNAs in cancer 0 -0.628458498 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Mitophagy - animal 0 0 -0.444015444 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Morphine addiction 0 0.482213439 0 kegg kegg NA NA no no no no up up Hepatocellular carcinoma mTOR signaling pathway -0.474782609 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Mucin type O-glycan biosynthesis 0 -0.614624506 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma N-Glycan biosynthesis 0 0.495059289 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma NF-kappa B signaling pathway 0 -0.668972332 -0.501930502 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Nicotinate and nicotinamide metabolism 0 -0.507905138 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Nitrogen metabolism 0 -0.663043478 -0.409009009 kegg kegg NA NA no no no no no no Hepatocellular carcinoma NOD-like receptor signaling pathway 0 -0.646245059 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Non-alcoholic fatty liver disease 0 0.540513834 0.505019305 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Osteoclast differentiation 0 -0.472332016 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Oxidative phosphorylation 0 0.617588933 0.57992278 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Oxytocin signaling pathway 0.82 0.720355731 0.474131274 kegg kegg NA NA no no no no no no Hepatocellular carcinoma p53 signaling pathway -0.648695652 -0.555335968 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Pancreatic secretion 0 0.62055336 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Pantothenate and CoA biosynthesis 0 -0.563241107 0 kegg kegg NA NA no no no no no dn Hepatocellular carcinoma Parkinson disease 0 0.499011858 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Pathogenic Escherichia coli infection 0 0 0.485199485 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Pathways in cancer 0 -0.4743083 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Pathways of neurodegeneration - multiple diseases 0 0.468379447 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Pentose and glucuronate interconversions 0 0.41798419 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Peroxisome 0 -0.65513834 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Phagosome 0.466086957 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Phenylalanine metabolism 0.553043478 0.566205534 0.628056628 kegg kegg NA NA no no no no no no Hepatocellular carcinoma PI3K-Akt signaling pathway -0.48173913 0 0 yes kegg kegg NA NA no no no no up up Hepatocellular carcinoma Platelet activation 0.853043478 0.878458498 0.740797941 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Platinum drug resistance -0.607826087 -0.449604743 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma PPAR signaling pathway 0 -0.524703557 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Prion disease 0 0.599802372 0.606177606 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Progesterone-mediated oocyte maturation -0.512173913 -0.41798419 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Prostate cancer 0 -0.429841897 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Proteasome -0.530434783 0.41798419 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Protein digestion and absorption 0 -0.455533597 0 yes kegg kegg NA NA no no no no up up Hepatocellular carcinoma Protein export -0.562608696 0.491106719 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Proteoglycans in cancer 0 0.53458498 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Proximal tubule bicarbonate reclamation 0 0.424901186 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Purine metabolism 0 0 -0.483140283 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Pyrimidine metabolism 0 0.416007905 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Rap1 signaling pathway 0.860869565 0.876482213 0.718146718 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Ras signaling pathway 0 0.539525692 0 yes kegg kegg NA NA no no no no up up Hepatocellular carcinoma Regulation of actin cytoskeleton 0.475652174 0.463438735 0.508365508 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Renal cell carcinoma 0 0 -0.46023166 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Renin secretion 0 0.589920949 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Retrograde endocannabinoid signaling 0 0.586956522 0.488803089 kegg kegg NA NA no no no no no up Hepatocellular carcinoma Ribosome 0 0.45256917 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Ribosome biogenesis in eukaryotes -0.519130435 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma RIG-I-like receptor signaling pathway -0.515652174 -0.700592885 -0.52972973 kegg kegg NA NA no no no no no no Hepatocellular carcinoma RNA degradation 0 0.448616601 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma RNA polymerase -0.673913043 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma RNA transport -0.475652174 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Salivary secretion 0 0.539525692 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Salmonella infection 0 0 0.492921493 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Selenocompound metabolism -0.590434783 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Small cell lung cancer 0 -0.56027668 -0.519433719 kegg kegg NA NA no no no no no up Hepatocellular carcinoma SNARE interactions in vesicular transport 0 -0.628458498 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Spinocerebellar ataxia -0.704347826 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Spliceosome -0.746956522 -0.471343874 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Starch and sucrose metabolism 0 -0.522727273 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma T cell receptor signaling pathway 0 -0.700592885 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Taurine and hypotaurine metabolism 0 -0.459486166 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Terpenoid backbone biosynthesis -0.464347826 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma TGF-beta signaling pathway 0 0.43083004 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Thermogenesis 0 0.623517787 0.502445302 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Thiamine metabolism 0 0 -0.498841699 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Thyroid hormone signaling pathway 0.96173913 0.96541502 0.947232947 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Tight junction 0.734782609 0.779644269 0.535392535 kegg kegg NA NA no no no no no no Hepatocellular carcinoma TNF signaling pathway 0 -0.498023715 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Toll-like receptor signaling pathway 0 -0.501976285 0 yes kegg kegg NA NA no no no no no no Hepatocellular carcinoma Transcriptional misregulation in cancer -0.730434783 -0.764822134 -0.549034749 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Type II diabetes mellitus 0 -0.520750988 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Tyrosine metabolism 0 0.416007905 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Ubiquitin mediated proteolysis 0 0 -0.407464607 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Various types of N-glycan biosynthesis -0.493913043 0 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Vascular smooth muscle contraction 0 0.59486166 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Vasopressin-regulated water reabsorption 0 0.558300395 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Vibrio cholerae infection 0.871304348 0.904150198 0.774259974 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Wnt signaling pathway 0 0.541501976 0 kegg kegg NA NA no no no no no no Hepatocellular carcinoma Yersinia infection 0.514782609 0 0.64967825 kegg kegg NA NA no no no no no no heptanoic acid C7+blood 14:0/20:4-PC+blood 0 0 -0.407179487 serum_mcfa serum_phospholipids 8.27E-11 0.486 dn dn no no no no heptanoic acid C7+blood 14:1/18:2-PG+blood 0 0.544117647 0 serum_mcfa serum_phospholipids 8.27E-11 0.00259 dn dn no no up up heptanoic acid C7+blood 16:0-LPE+blood 0 0 -0.40991453 serum_mcfa serum_phospholipids 8.27E-11 0.0711 dn dn no up up no heptanoic acid C7+blood 16:0/16:1-PC+blood 0 0 -0.422905983 serum_mcfa serum_phospholipids 8.27E-11 0.00283 dn dn no up up no heptanoic acid C7+blood 16:0/20:5-PC+blood 0 -0.49754902 0 serum_mcfa serum_phospholipids 8.27E-11 0.628 dn dn no no no no heptanoic acid C7+blood 16:0/22:6-PE+blood 0 -0.522058824 0 serum_mcfa serum_phospholipids 8.27E-11 0.000934 dn dn no up up no heptanoic acid C7+blood 18:0-LPE+blood 0 0 -0.587008547 serum_mcfa serum_phospholipids 8.27E-11 0.491 dn dn no no no no heptanoic acid C7+blood 18:0/22:6-PE+blood 0 -0.553921569 0 serum_mcfa serum_phospholipids 8.27E-11 0.00022 dn dn no up up no heptanoic acid C7+blood 18:0+blood 0.448120301 0 0 serum_mcfa serum_fattyacid 8.27E-11 0.344 dn dn no no no no heptanoic acid C7+blood 18:1/20:3-PC+blood 0 0.524509804 0 serum_mcfa serum_phospholipids 8.27E-11 0.00872 dn dn no no up up heptanoic acid C7+blood 2-methyl-butyric acid m-C4+blood 0.502255639 0 0.50017094 serum_mcfa serum_scfa 8.27E-11 0.262 dn dn no no no no heptanoic acid C7+blood 20:0/20:4-PE+blood -0.448120301 0 0 serum_mcfa serum_phospholipids 8.27E-11 0.00128 dn dn no up up no heptanoic acid C7+blood 20:1-LPA+blood 0 0.512254902 0 serum_mcfa serum_phospholipids 8.27E-11 0.0187 dn dn no dn dn no heptanoic acid C7+blood 20:2-LPE+blood -0.596992481 0 0 serum_mcfa serum_phospholipids 8.27E-11 0.177 dn dn no no no no heptanoic acid C7+blood 20:2+blood 0 0.50245098 0 serum_mcfa serum_fattyacid 8.27E-11 0.478 dn dn no no no no heptanoic acid C7+blood 20:3-LPE+blood 0 0.62745098 -0.442735043 serum_mcfa serum_phospholipids 8.27E-11 0.084 dn dn no no up no heptanoic acid C7+blood 20:4-LPA+blood 0 0.544117647 0 serum_mcfa serum_phospholipids 8.27E-11 0.398 dn dn no no no no heptanoic acid C7+blood 20:5-LPC+blood 0 -0.632352941 0 serum_mcfa serum_phospholipids 8.27E-11 0.558 dn dn no no no no heptanoic acid C7+blood 20:5n3+blood 0 -0.553921569 0 serum_mcfa serum_fattyacid 8.27E-11 0.988 dn dn no no no no heptanoic acid C7+blood 22:1-LPA+blood 0 0.610294118 0 serum_mcfa serum_phospholipids 8.27E-11 0.00373 dn dn no no up up heptanoic acid C7+blood 22:2-LPA+blood 0 0.659313725 0 serum_mcfa serum_phospholipids 8.27E-11 0.0443 dn dn no dn no no heptanoic acid C7+blood 24:1+blood 0.526315789 0 0 serum_mcfa serum_fattyacid 8.27E-11 0.00582 dn dn no no dn dn heptanoic acid C7+blood acetic acid C2+blood 0.512781955 0 0 serum_mcfa serum_scfa 8.27E-11 0.000193 dn dn no up dn no heptanoic acid C7+blood butyric acid C4+blood 0.514285714 0 0 serum_mcfa serum_scfa 8.27E-11 0.407 dn dn no no no no heptanoic acid C7+blood Cysteine+blood 0 0.730392157 0 yes serum_mcfa serum_aminoacids 8.27E-11 1.81E-07 dn dn no dn up up heptanoic acid C7+blood Cystine+blood 0.464661654 0 0 yes serum_mcfa serum_aminoacids 8.27E-11 0.00028 dn dn no up up no heptanoic acid C7+blood d18:0-16:0-SM+blood -0.445112782 0 0 serum_mcfa serum_phospholipids 8.27E-11 0.202 dn dn no no no no heptanoic acid C7+blood d18:1-14:1-SM+blood 0 0 -0.465299145 serum_mcfa serum_phospholipids 8.27E-11 0.0952 dn dn no no dn no heptanoic acid C7+blood d18:1-16:0-SM+blood -0.481203008 0 0 serum_mcfa serum_phospholipids 8.27E-11 0.14 dn dn no no no no heptanoic acid C7+blood d18:1-20:0-SM+blood -0.50075188 0 0 serum_mcfa serum_phospholipids 8.27E-11 0.933 dn dn no no no no heptanoic acid C7+blood decanoic acid C10+blood 0.738345865 0.519607843 0 serum_mcfa serum_mcfa 8.27E-11 6.64E-11 dn dn no dn dn no heptanoic acid C7+blood DMG+blood 0 0 0.439316239 serum_mcfa serum_choline 8.27E-11 0.909 dn dn no no no no Herpes simplex virus 1 infection Antifolate resistance -0.545217391 -0.588932806 -0.414414414 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Antigen processing and presentation 0.96 0.944664032 0.935649936 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Axon guidance 0 0.454545455 0 kegg kegg NA NA no no no no up up Herpes simplex virus 1 infection Biosynthesis of cofactors 0 -0.441699605 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Cell adhesion molecules 0.423478261 0.520750988 0.66975547 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Cellular senescence 0.536521739 0.445652174 0.590990991 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Cholesterol metabolism 0.44 0.502964427 0 yes kegg kegg NA NA no no no no no up Herpes simplex virus 1 infection Cocaine addiction 0 -0.495059289 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Cortisol synthesis and secretion -0.464347826 -0.567193676 0 kegg kegg NA NA no no no no no up Herpes simplex virus 1 infection Cushing syndrome -0.52173913 -0.503952569 0 kegg kegg NA NA no no no no no up Herpes simplex virus 1 infection Desulfovibrio 0 0.422326513 0 kegg Genus NA 0.27 no no no no no no Herpes simplex virus 1 infection Drug metabolism - cytochrome P450 0.433043478 0 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Endocrine resistance -0.586086957 -0.673913043 -0.431145431 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Endocytosis 0.486086957 0.511857708 0.60952381 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Ether lipid metabolism -0.486086957 0 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Fanconi anemia pathway 0 -0.502964427 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Fructose and mannose metabolism 0 -0.57312253 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Glycerolipid metabolism -0.410434783 -0.491106719 0 kegg kegg NA NA no no no no no up Herpes simplex virus 1 infection Glycerophospholipid metabolism -0.676521739 -0.56027668 0 kegg kegg NA NA no no no no no up Herpes simplex virus 1 infection "Glycine, serine and threonine metabolism" 0 -0.488142292 0 kegg kegg NA NA no no no no up no Herpes simplex virus 1 infection Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.516798419 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection GnRH secretion 0 0 -0.42007722 kegg kegg NA NA no no no no up up Herpes simplex virus 1 infection GnRH signaling pathway 0 -0.438735178 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection "Growth hormone synthesis, secretion and action" -0.443478261 -0.542490119 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Hedgehog signaling pathway -0.569565217 -0.511857708 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Homologous recombination 0 -0.418972332 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Human cytomegalovirus infection 0.940869565 0.945652174 0.882882883 kegg kegg NA NA no no no no no dn Herpes simplex virus 1 infection Human papillomavirus infection 0.466956522 0 0.509395109 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Human T-cell leukemia virus 1 infection 0.973043478 0.97826087 0.968854569 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Inositol phosphate metabolism -0.506956522 -0.449604743 -0.506563707 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Insulin secretion -0.496521739 -0.437747036 0 yes kegg kegg NA NA no no no no up up Herpes simplex virus 1 infection Lachnospira -0.417391304 0 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Herpes simplex virus 1 infection Leishmaniasis 0.454782609 0 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Leukocyte transendothelial migration 0 0.420948617 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Lysine degradation 0 -0.493083004 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Lysosome 0 0.454545455 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Maturity onset diabetes of the young 0 -0.415019763 0 kegg kegg NA NA no no no no up no Herpes simplex virus 1 infection Natural killer cell mediated cytotoxicity 0.569565217 0.510869565 0.655083655 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Neuroactive ligand-receptor interaction 0 0.509881423 0 kegg kegg NA NA no no no up up up Herpes simplex virus 1 infection Nicotine addiction 0 -0.536561265 0 kegg kegg NA NA no no no no up up Herpes simplex virus 1 infection Notch signaling pathway 0 -0.498023715 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Other types of O-glycan biosynthesis 0 -0.526679842 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Ovarian steroidogenesis -0.495652174 -0.435770751 0 kegg kegg NA NA no no no no up up Herpes simplex virus 1 infection Phagosome 0 0.48715415 0.553410553 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Phospholipase D signaling pathway 0 0 -0.4002574 kegg kegg NA NA no no no no up up Herpes simplex virus 1 infection Phototransduction 0 0.455533597 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Platinum drug resistance 0 -0.445652174 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Porphyrin and chlorophyll metabolism 0 -0.416996047 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection PPAR signaling pathway 0.493043478 0 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Progesterone-mediated oocyte maturation 0 -0.438735178 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Proteasome 0.416521739 0 0.493693694 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Protein digestion and absorption 0 0 -0.423938224 yes kegg kegg NA NA no no no no up up Herpes simplex virus 1 infection Purine metabolism 0 -0.501976285 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Regulation of actin cytoskeleton 0.423478261 0 0.458429858 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Regulation of lipolysis in adipocytes 0 -0.469367589 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Renin-angiotensin system 0 0.468379447 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Salmonella infection 0.451304348 0.470355731 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Selenocompound metabolism 0 -0.542490119 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Signaling pathways regulating pluripotency of stem cells 0 0 -0.419047619 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Sphingolipid signaling pathway 0 0.494071146 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Staphylococcus aureus infection 0 0.472332016 0 kegg kegg NA NA no no no up no no Herpes simplex virus 1 infection Taste transduction 0 0 -0.416216216 kegg kegg NA NA no no no no no up Herpes simplex virus 1 infection Taurine and hypotaurine metabolism 0 -0.522727273 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Tuberculosis 0 0.424901186 0 kegg kegg NA NA no no no no no dn Herpes simplex virus 1 infection Type I diabetes mellitus 0 0.526679842 0.694465894 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Vasopressin-regulated water reabsorption -0.493043478 0 0 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Viral protein interaction with cytokine and cytokine receptor 0 0 0.406177606 kegg kegg NA NA no no no no no no Herpes simplex virus 1 infection Vitamin digestion and absorption -0.5 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway ABC transporters 0 -0.577075099 0 kegg kegg NA NA no no no no up up HIF-1 signaling pathway "Alanine, aspartate and glutamate metabolism" 0 -0.555335968 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Alistipes 0 0 -0.423196228 kegg Genus NA 0.0114 no no no no up no HIF-1 signaling pathway alpha-Linolenic acid metabolism 0 -0.738142292 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Arginine and proline metabolism 0 -0.586956522 0 kegg kegg NA NA no no no no up no HIF-1 signaling pathway Arginine biosynthesis 0 -0.509881423 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Basal transcription factors 0.573913043 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Base excision repair 0.572173913 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Bifidobacterium 0 0.421497083 0 acetate-producing kegg Genus NA 0.105 no no no no dn no HIF-1 signaling pathway Butanoate metabolism 0 0.558300395 0.574002574 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Citrate cycle (TCA cycle) 0 0.575098814 0.514285714 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Cysteine and methionine metabolism 0.41826087 0.773715415 0.597940798 kegg kegg NA NA no no no no no no HIF-1 signaling pathway DNA replication 0.500869565 0.494071146 0.515830116 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Drug metabolism - cytochrome P450 0 0.589920949 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Drug metabolism - other enzymes 0 0.615612648 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway EGFR tyrosine kinase inhibitor resistance 0.908695652 0.954545455 0.951351351 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Endocrine resistance 0 0 -0.409266409 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Fatty acid biosynthesis 0 -0.562252964 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Fatty acid degradation 0 -0.435770751 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Fatty acid elongation 0 0.453557312 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Fructose and mannose metabolism 0 -0.628458498 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Galactose metabolism 0 -0.597826087 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Glutathione metabolism 0 0.633399209 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Glycerolipid metabolism 0 -0.650197628 0 kegg kegg NA NA no no no no no up HIF-1 signaling pathway Glycerophospholipid metabolism 0 -0.621541502 0 kegg kegg NA NA no no no no no up HIF-1 signaling pathway Glycolysis / Gluconeogenesis 0 0.793478261 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.736166008 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Glycosaminoglycan degradation -0.416521739 -0.468379447 0 kegg kegg NA NA no no no no no up HIF-1 signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0 -0.479249012 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Glyoxylate and dicarboxylate metabolism 0 -0.459486166 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Inositol phosphate metabolism 0 -0.455533597 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Lysine degradation 0.636521739 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Metabolism of xenobiotics by cytochrome P450 0 0.551383399 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Mismatch repair 0 0.440711462 0.428056628 kegg kegg NA NA no no no no no no HIF-1 signaling pathway mRNA surveillance pathway 0 0.422924901 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway N-Glycan biosynthesis 0 0.518774704 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway NF-kappa B signaling pathway 0 -0.695652174 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Nicotinate and nicotinamide metabolism 0 -0.613636364 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Nitrogen metabolism 0 -0.467391304 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Non-homologous end-joining 0 0.548418972 0.447361647 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Nucleotide excision repair 0.432173913 0 0.423938224 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Other glycan degradation 0 -0.584980237 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Oxidative phosphorylation 0 0.639328063 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Pantothenate and CoA biosynthesis 0 -0.624505929 0 kegg kegg NA NA no no no no no dn HIF-1 signaling pathway Parabacteroides 0 0 -0.445202395 kegg Genus NA 4.19E-05 no no no no up up HIF-1 signaling pathway Pentose and glucuronate interconversions 0 0.52173913 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Propanoate metabolism 0 0.81027668 0.706821107 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Proteasome 0.512173913 0.624505929 0.562419562 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Protein export 0.51826087 0.726284585 0.508622909 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Pyruvate metabolism 0 0.805335968 0.575032175 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Rap1 signaling pathway -0.591304348 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Ras signaling pathway 0 0.416996047 0 yes kegg kegg NA NA no no no no up up HIF-1 signaling pathway Ribosome 0.555652174 0.87944664 0.793050193 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Ribosome biogenesis in eukaryotes 0.651304348 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway RNA degradation 0 0.588932806 0.421364221 kegg kegg NA NA no no no no no no HIF-1 signaling pathway RNA polymerase 0.594782609 0.441699605 0.471557272 kegg kegg NA NA no no no no no no HIF-1 signaling pathway RNA transport 0.626086957 0.933794466 0.734105534 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Selenocompound metabolism 0.492173913 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Spliceosome 0.684347826 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Starch and sucrose metabolism 0 -0.662055336 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Taurine and hypotaurine metabolism 0 -0.592885375 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Terpenoid backbone biosynthesis 0.406086957 0 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Thiamine metabolism 0 0.686758893 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Tryptophan metabolism 0 0.414031621 0.513256113 kegg kegg NA NA no no no no up no HIF-1 signaling pathway Tyrosine metabolism 0 0.42687747 0 kegg kegg NA NA no no no no no no HIF-1 signaling pathway "Valine, leucine and isoleucine degradation" 0 0 0.461776062 kegg kegg NA NA no no no no no no HIF-1 signaling pathway Various types of N-glycan biosynthesis 0.567826087 0.416007905 0 kegg kegg NA NA no no no no no no hipline+clinic 12-ketoDCA+stool 0 0 -0.424054207 clinic stool_bileacids 8.08E-05 0.505 up up no no no no hipline+clinic 15-HETE+blood 0 0 0.498894461 clinic serum_ARA 8.08E-05 0.819 up up no no no no hipline+clinic 16:0/16:0-PC+blood 0.562435501 0 0 clinic serum_phospholipids 8.08E-05 0.00079 up up no no up up hipline+clinic 16:0/18:2-PI+blood 0 -0.603571429 0 clinic serum_phospholipids 8.08E-05 0.269 up up no no no no hipline+clinic 16:1/16:0-PC+blood 0 0 0.414615385 clinic serum_phospholipids 8.08E-05 0.0215 up up no no up up hipline+clinic 18:0-LPC+blood 0 -0.564285714 0 clinic serum_phospholipids 8.08E-05 0.554 up up no no no no hipline+clinic 18:0/18:1-PE+blood 0 0 -0.501538462 clinic serum_phospholipids 8.08E-05 0.00716 up up no up up no hipline+clinic 18:0/20:3-PC+blood 0 0 -0.472307692 clinic serum_phospholipids 8.08E-05 0.0682 up up no no up no hipline+clinic 18:0/20:3-PI+blood 0 0 -0.429230769 clinic serum_phospholipids 8.08E-05 0.377 up up no no no no hipline+clinic 18:0/20:5-PC+blood 0 0 0.453076923 clinic serum_phospholipids 8.08E-05 0.17 up up no no no no hipline+clinic 18:1/18:1-PE+blood 0 -0.567857143 0 clinic serum_phospholipids 8.08E-05 1.03E-05 up up no up up no hipline+clinic 18:2/16:0-PC+blood 0.475748194 0 0 clinic serum_phospholipids 8.08E-05 8.67E-05 up up no no up up hipline+clinic 20:1-LPA+blood 0.560371517 0 0 clinic serum_phospholipids 8.08E-05 0.0187 up up no dn dn no hipline+clinic 20:2/18:0-PC+blood 0 0 -0.486923077 clinic serum_phospholipids 8.08E-05 0.0427 up up no no up no hipline+clinic 20:3/18:0-PC+blood 0 0 0.437692308 clinic serum_phospholipids 8.08E-05 0.296 up up no no no no hipline+clinic 20:3n6+blood -0.636738906 0 -0.499230769 clinic serum_fattyacid 8.08E-05 0.0884 up up no up no no hipline+clinic 24:1+blood 0 0 0.477692308 clinic serum_fattyacid 8.08E-05 0.00582 up up no no dn dn hipline+clinic 4-hydroxybenzoic acid+urine 0 0 0.407692308 clinic urine_cometabolism 8.08E-05 0.52 up up no no no no hipline+clinic AA+blood 0 0.610714286 0 clinic serum_ARA 8.08E-05 0.212 up up no no no no hipline+clinic Akkermansia 0 0 -0.405127354 acetate-producing clinic Genus 8.08E-05 0.23 up up no no no no hipline+clinic Bacteroides 0 0.487295313 0 LPS-producing clinic Genus 8.08E-05 0.000267 up up no dn dn up hipline+clinic Blautia -0.445652174 0 0 acetate-producing clinic Genus 8.08E-05 1.36E-05 up up no up dn dn hipline+clinic C-peptide 0 -0.511010728 0 clinic DM-assocaited hormones 8.08E-05 0.228 up up no no no no hipline+clinic Cystine+blood 0 0 0.421538462 yes clinic serum_aminoacids 8.08E-05 0.00028 up up no up up no hipline+clinic d18:1-18:0-SM+blood 0 0 0.442307692 clinic serum_phospholipids 8.08E-05 0.97 up up no no no no hipline+clinic Endocrine resistance 0 -0.437662338 0 clinic kegg 8.08E-05 NA up up no no no no hipline+clinic FGF basic 0.565934066 0 0 clinic serum_cytokines 8.08E-05 0.65 up up no no no no hipline+clinic Glycine+blood 0 0 0.528461538 clinic serum_aminoacids 8.08E-05 0.00408 up up no dn no up hipline+clinic L-2-Aminobutyric acid+blood 0 0.546428571 0 yes clinic serum_aminoacids 8.08E-05 0.000328 up up no up up no hipline+clinic L-Glutamine+blood 0 0 0.419230769 clinic serum_aminoacids 8.08E-05 0.639 up up no no no no hipline+clinic L-Proline+blood 0 -0.671428571 0 yes clinic serum_aminoacids 8.08E-05 0.00265 up up no up up no hipline+clinic Legionellosis 0 0.48961039 0 clinic kegg 8.08E-05 NA up up no no no no hipline+clinic Measles 0 0.657142857 0 clinic kegg 8.08E-05 NA up up no no no no hipline+clinic Methanobrevibacter 0 0.427723611 0 clinic Genus 8.08E-05 0.629 up up no no no no hipline+clinic Morphine addiction 0 -0.437662338 0 clinic kegg 8.08E-05 NA up up no no up up hipline+clinic Oscillospira 0 0.470355731 0 LPS-producing clinic Genus 8.08E-05 0.62 up up no no no no hipline+clinic Parabacteroides 0 0.465838509 0 clinic Genus 8.08E-05 4.19E-05 up up no no up up hipline+clinic Paraprevotella 0 -0.521068879 0 clinic Genus 8.08E-05 0.118 up up no no no no hipline+clinic PI3K-Akt signaling pathway 0.460191982 0.518181818 0 yes clinic kegg 8.08E-05 NA up up no no up up hipline+clinic Primary immunodeficiency 0.483907397 0 0 clinic kegg 8.08E-05 NA up up no no no no hipline+clinic Rap1 signaling pathway 0 -0.448051948 0 clinic kegg 8.08E-05 NA up up no no no no hipline+clinic Regulation of lipolysis in adipocytes 0 -0.435064935 0 clinic kegg 8.08E-05 NA up up no no no no hipline+clinic Roseburia 0 -0.471053394 0 butyrate-producing clinic Genus 8.08E-05 0.495 up up no no no no hipline+clinic Toxoplasmosis 0 0.444155844 0 clinic kegg 8.08E-05 NA up up no no no no hipline+clinic Viral myocarditis -0.438735178 0 0 clinic kegg 8.08E-05 NA up up no no no no hipline+clinic Visfatin 0 0 0.497326203 clinic DM-assocaited hormones 8.08E-05 0.0229 up up no dn no up Hippo signaling pathway 2-Oxocarboxylic acid metabolism 0.406086957 0.652173913 0 kegg kegg NA NA no no no no no no Hippo signaling pathway ABC transporters 0 -0.522727273 0 kegg kegg NA NA no no no no up up Hippo signaling pathway Adrenergic signaling in cardiomyocytes 0 0.4743083 0 kegg kegg NA NA no no no no no up Hippo signaling pathway "Alanine, aspartate and glutamate metabolism" -0.568695652 -0.826086957 0 kegg kegg NA NA no no no no no no Hippo signaling pathway alpha-Linolenic acid metabolism 0 -0.523715415 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Apelin signaling pathway 0 0.536561265 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Apoptosis - multiple species -0.56173913 -0.482213439 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Arginine and proline metabolism 0 -0.713438735 -0.551866152 kegg kegg NA NA no no no no up no Hippo signaling pathway Arginine biosynthesis -0.482608696 -0.773715415 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Ascorbate and aldarate metabolism 0 0.504940711 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Autophagy - animal -0.808695652 -0.885375494 -0.41981982 kegg kegg NA NA no no no no no no Hippo signaling pathway Autophagy - other -0.753913043 -0.615612648 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Basal transcription factors -0.50173913 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Base excision repair -0.454782609 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway beta-Alanine metabolism 0 0.419960474 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Bifidobacterium 0 0.507183328 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Hippo signaling pathway Biosynthesis of unsaturated fatty acids 0 0 0.404890605 kegg kegg NA NA no no no no no no Hippo signaling pathway Butanoate metabolism 0 0.58201581 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Calcium signaling pathway 0 0.453557312 0 kegg kegg NA NA no no no no up up Hippo signaling pathway Cardiac muscle contraction 0 0.670948617 0.623423423 kegg kegg NA NA no no no no no up Hippo signaling pathway cGMP-PKG signaling pathway 0 -0.444664032 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Citrate cycle (TCA cycle) 0 0.575098814 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Cysteine and methionine metabolism 0 0.5 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Cytokine-cytokine receptor interaction 0 0 0.594594595 kegg kegg NA NA no no no no no no Hippo signaling pathway DNA replication 0 0.515810277 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Drug metabolism - cytochrome P450 0 0.697628458 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Drug metabolism - other enzymes 0 0.814229249 0 kegg kegg NA NA no no no no no no Hippo signaling pathway EGFR tyrosine kinase inhibitor resistance 0 0.425889328 0 kegg kegg NA NA no no no no no no Hippo signaling pathway ErbB signaling pathway 0 -0.484189723 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Fatty acid biosynthesis -0.526956522 -0.741106719 -0.472329472 kegg kegg NA NA no no no no no no Hippo signaling pathway Fatty acid degradation 0 -0.635375494 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Fatty acid metabolism 0 -0.587944664 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Folate biosynthesis 0 0.616600791 0 kegg kegg NA NA no no no no no no Hippo signaling pathway FoxO signaling pathway -0.506956522 -0.697628458 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Galactose metabolism 0 -0.427865613 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Glutathione metabolism 0 0.442687747 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Glycerolipid metabolism 0 -0.563241107 0 kegg kegg NA NA no no no no no up Hippo signaling pathway Glycerophospholipid metabolism 0 -0.612648221 0 kegg kegg NA NA no no no no no up Hippo signaling pathway Glycolysis / Gluconeogenesis 0 0.615612648 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.693675889 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.651304348 0.524703557 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Glyoxylate and dicarboxylate metabolism -0.44173913 -0.767786561 0 kegg kegg NA NA no no no no no no Hippo signaling pathway HIF-1 signaling pathway -0.449565217 0.501976285 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Inositol phosphate metabolism 0 -0.477272727 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Lachnospira 0 0.553496434 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Hippo signaling pathway Longevity regulating pathway 0 -0.482213439 0 kegg kegg NA NA no no no no no no Hippo signaling pathway MAPK signaling pathway 0 -0.563241107 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Metabolism of xenobiotics by cytochrome P450 0 0.727272727 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Mucin type O-glycan biosynthesis 0 -0.486166008 0 kegg kegg NA NA no no no no no no Hippo signaling pathway N-Glycan biosynthesis 0 0.666007905 0 kegg kegg NA NA no no no no no no Hippo signaling pathway NF-kappa B signaling pathway -0.488695652 -0.776679842 -0.638610039 kegg kegg NA NA no no no no no no Hippo signaling pathway Nicotinate and nicotinamide metabolism -0.452173913 -0.664031621 -0.407722008 kegg kegg NA NA no no no no no no Hippo signaling pathway Nitrogen metabolism 0 -0.792490119 -0.430888031 kegg kegg NA NA no no no no no no Hippo signaling pathway Notch signaling pathway 0 -0.416007905 0 kegg kegg NA NA no no no no no no Hippo signaling pathway One carbon pool by folate 0 0.466403162 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Oocyte meiosis 0 0.51284585 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Osteoclast differentiation 0 -0.56027668 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Oxidative phosphorylation 0 0.662055336 0.595624196 kegg kegg NA NA no no no no no no Hippo signaling pathway p53 signaling pathway -0.648695652 -0.542490119 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Pantothenate and CoA biosynthesis 0 -0.619565217 0 kegg kegg NA NA no no no no no dn Hippo signaling pathway Paraprevotella 0 0.446186177 0 kegg Genus NA 0.118 no no no no no no Hippo signaling pathway Pentose and glucuronate interconversions 0.443478261 0.637351779 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Peroxisome -0.459130435 -0.67687747 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Phenylalanine metabolism 0.734782609 0.688735178 0.558558559 kegg kegg NA NA no no no no no no Hippo signaling pathway Phospholipase D signaling pathway 0 -0.571146245 0 kegg kegg NA NA no no no no up up Hippo signaling pathway PI3K-Akt signaling pathway -0.411304348 0 0 yes kegg kegg NA NA no no no no up up Hippo signaling pathway Platinum drug resistance -0.593043478 -0.416996047 0 kegg kegg NA NA no no no no no no Hippo signaling pathway PPAR signaling pathway -0.431304348 -0.64229249 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Prevotella 0 -0.449293214 0 acetate-producing kegg Genus NA 0.287 no no no no no no Hippo signaling pathway Propanoate metabolism 0 0.455533597 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Proteasome -0.483478261 0.632411067 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Protein export 0 0.687747036 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Protein processing in endoplasmic reticulum 0 0.517786561 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Purine metabolism 0 0 -0.522522523 kegg kegg NA NA no no no no no no Hippo signaling pathway Pyrimidine metabolism 0 0.54743083 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Pyruvate metabolism 0 0.513833992 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Rap1 signaling pathway 0.750434783 0.755928854 0.741312741 kegg kegg NA NA no no no no no no Hippo signaling pathway Ras signaling pathway 0 0.679841897 0 yes kegg kegg NA NA no no no no up up Hippo signaling pathway Ribosome 0 0.52173913 0 kegg kegg NA NA no no no no no no Hippo signaling pathway RNA degradation 0 0.583003953 0 kegg kegg NA NA no no no no no no Hippo signaling pathway RNA polymerase -0.459130435 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Selenocompound metabolism -0.57826087 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway SNARE interactions in vesicular transport 0 -0.609683794 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Spliceosome -0.630434783 0 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Starch and sucrose metabolism 0 -0.657114625 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Taurine and hypotaurine metabolism 0 -0.613636364 0 kegg kegg NA NA no no no no no no Hippo signaling pathway TGF-beta signaling pathway 0 0.638339921 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Thiamine metabolism 0 0 -0.563191763 kegg kegg NA NA no no no no no no Hippo signaling pathway Tryptophan metabolism 0 0.500988142 0 kegg kegg NA NA no no no no up no Hippo signaling pathway Tyrosine metabolism 0.409565217 0.538537549 0 kegg kegg NA NA no no no no no no Hippo signaling pathway "Valine, leucine and isoleucine degradation" 0 0.501976285 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Various types of N-glycan biosynthesis 0 0.501976285 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Vascular smooth muscle contraction 0 0.656126482 0 kegg kegg NA NA no no no no no no Hippo signaling pathway Wnt signaling pathway 0 0.660079051 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Adrenergic signaling in cardiomyocytes 0 -0.628458498 0 kegg kegg NA NA no no no no no up Hippo signaling pathway - multiple species "Alanine, aspartate and glutamate metabolism" 0 0.641304348 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species alpha-Linolenic acid metabolism 0 0.658102767 0.594079794 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species AMPK signaling pathway -0.673043478 -0.51284585 -0.693178893 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Apelin signaling pathway 0 -0.780632411 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Apoptosis 0 0.639328063 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Arginine and proline metabolism 0.432173913 0.805335968 0 kegg kegg NA NA no no no no up no Hippo signaling pathway - multiple species Arginine biosynthesis 0 0.56027668 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Ascorbate and aldarate metabolism 0 0 0.497039897 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Autophagy - animal 0 0.670948617 0.476962677 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Biosynthesis of cofactors -0.633043478 0 -0.528185328 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Butanoate metabolism 0 -0.48715415 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Calcium signaling pathway 0 -0.574110672 0 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Cardiac muscle contraction 0 -0.760869565 0 kegg kegg NA NA no no no no no up Hippo signaling pathway - multiple species Cell cycle 0 -0.462450593 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species cGMP-PKG signaling pathway 0.584347826 0.598814229 0.503989704 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Chemokine signaling pathway 0 0.440711462 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Citrate cycle (TCA cycle) 0 -0.447628458 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Cysteine and methionine metabolism 0 -0.581027668 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species DNA replication 0 -0.523715415 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Drug metabolism - cytochrome P450 0 -0.519762846 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Drug metabolism - other enzymes 0 -0.516798419 0.46023166 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species EGFR tyrosine kinase inhibitor resistance 0 -0.758893281 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species ErbB signaling pathway 0 0 0.47953668 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Fatty acid biosynthesis 0 0.600790514 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Fatty acid degradation 0 0.467391304 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Fatty acid metabolism 0 0.48715415 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species FoxO signaling pathway 0 0.522727273 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Fructose and mannose metabolism 0 0.444664032 0.476447876 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Galactose metabolism 0 0.523715415 0.567310167 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Glutathione metabolism -0.503478261 -0.592885375 -0.562419562 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Glycerolipid metabolism 0 0.428853755 0.540540541 kegg kegg NA NA no no no no no up Hippo signaling pathway - multiple species Glycerophospholipid metabolism 0 0 0.483397683 kegg kegg NA NA no no no no no up Hippo signaling pathway - multiple species "Glycine, serine and threonine metabolism" -0.693043478 -0.470355731 -0.524581725 kegg kegg NA NA no no no no up no Hippo signaling pathway - multiple species Glycolysis / Gluconeogenesis 0 -0.556324111 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.583003953 0.713770914 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.603861004 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Glycosaminoglycan degradation 0.431304348 0.601778656 0.794594595 kegg kegg NA NA no no no no no up Hippo signaling pathway - multiple species Glyoxylate and dicarboxylate metabolism 0 0.568181818 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species HIF-1 signaling pathway 0 -0.756916996 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Hippo signaling pathway 0 -0.577075099 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Histidine metabolism 0 0.51284585 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Inositol phosphate metabolism 0 0 0.475160875 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Longevity regulating pathway 0 0 -0.613899614 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Lysine degradation 0 0 0.422136422 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Lysosome 0.512173913 0 0.516087516 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species MAPK signaling pathway 0 0.425889328 0.44993565 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Metabolism of xenobiotics by cytochrome P450 0 -0.453557312 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Mitophagy - animal 0 -0.604743083 -0.629343629 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species mRNA surveillance pathway 0 -0.483201581 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species mTOR signaling pathway 0 -0.719367589 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species N-Glycan biosynthesis 0 -0.592885375 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Necroptosis 0 0 -0.464092664 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Neuroactive ligand-receptor interaction 0 0.429841897 0 kegg kegg NA NA no no no up up up Hippo signaling pathway - multiple species NF-kappa B signaling pathway 0.526086957 0.719367589 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Nicotinate and nicotinamide metabolism 0.409565217 0.670948617 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Nitrogen metabolism 0 0.545454545 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Notch signaling pathway 0.471304348 0 0.638352638 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Oocyte meiosis 0 -0.454545455 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Osteoclast differentiation 0.646956522 0.647233202 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Other glycan degradation 0 0.545454545 0.685971686 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Oxidative phosphorylation 0 -0.730237154 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Pantothenate and CoA biosynthesis 0.547826087 0.770750988 0 kegg kegg NA NA no no no no no dn Hippo signaling pathway - multiple species Pentose and glucuronate interconversions 0 -0.451581028 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Pentose phosphate pathway 0 0.414031621 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Peroxisome 0 0.563241107 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Phospholipase D signaling pathway 0 0.574110672 0 kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Porphyrin and chlorophyll metabolism -0.726086957 0 -0.551608752 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species PPAR signaling pathway 0.433043478 0.43972332 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Propanoate metabolism 0 -0.58201581 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Proteasome 0 -0.472332016 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Protein export 0 -0.580039526 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Protein processing in endoplasmic reticulum -0.406956522 -0.548418972 -0.587644788 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Purine metabolism -0.632173913 -0.420948617 -0.458687259 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Pyruvate metabolism 0 -0.648221344 -0.471814672 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Ras signaling pathway 0 -0.448616601 0 yes kegg kegg NA NA no no no no up up Hippo signaling pathway - multiple species Ribosome 0 -0.798418972 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Ribosome biogenesis in eukaryotes 0 -0.41798419 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species RNA degradation 0 -0.549407115 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species RNA polymerase 0 -0.522727273 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species RNA transport 0 -0.684782609 -0.407464607 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species SNARE interactions in vesicular transport 0.422608696 0.72826087 0.493178893 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Sphingolipid metabolism 0 0 0.742857143 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Sphingolipid signaling pathway 0 0 0.573745174 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Starch and sucrose metabolism 0 0.708498024 0.575804376 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species TGF-beta signaling pathway 0 -0.489130435 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Thiamine metabolism 0 -0.502964427 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Ubiquitin mediated proteolysis 0 -0.619565217 -0.64015444 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Various types of N-glycan biosynthesis 0 -0.489130435 0 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Vascular smooth muscle contraction 0 -0.597826087 -0.446589447 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species VEGF signaling pathway 0 0 0.56010296 kegg kegg NA NA no no no no no no Hippo signaling pathway - multiple species Wnt signaling pathway 0 -0.603754941 0 kegg kegg NA NA no no no no no no Hippuric acid+urine 12-ketoDCA+stool 0 0.711303297 0 urine_cometabolism stool_bileacids 0.361 0.505 no no no no no no Hippuric acid+urine 13-HODE+blood 0 0 0.588311688 urine_cometabolism serum_ARA 0.361 0.32 no no no no no no Hippuric acid+urine 16:0/18:2-PC+blood 0 0 0.485714286 urine_cometabolism serum_phospholipids 0.361 3.24E-06 no no no no up up Hippuric acid+urine 16:0/22:6-PC+blood 0 0 0.448051948 urine_cometabolism serum_phospholipids 0.361 4.53E-05 no no no no up up Hippuric acid+urine 18:0/18:2-PC+blood 0 0 0.464935065 urine_cometabolism serum_phospholipids 0.361 1.74E-06 no no no no up up Hippuric acid+urine 18:0/22:6-PC+blood 0 0 0.492207792 urine_cometabolism serum_phospholipids 0.361 0.0775 no no no no no up Hippuric acid+urine 18:0+blood 0 0 0.557142857 urine_cometabolism serum_fattyacid 0.361 0.344 no no no no no no Hippuric acid+urine 18:1/16:0-PC+blood 0 0 0.471428571 urine_cometabolism serum_phospholipids 0.361 2.43E-05 no no no no up up Hippuric acid+urine 18:1/18:0-PC+blood 0 0 0.448051948 urine_cometabolism serum_phospholipids 0.361 1.83E-06 no no no no up up Hippuric acid+urine 18:2/20:4-PC+blood 0 0.576923077 0 urine_cometabolism serum_phospholipids 0.361 0.0145 no no no no no up Hippuric acid+urine 18:3n6+blood 0 0.565934066 0 urine_cometabolism serum_fattyacid 0.361 0.0463 no no no up no dn Hippuric acid+urine 2-hydroxyphenylacetic acid+urine 0 0 -0.401025641 urine_cometabolism urine_cometabolism 0.361 0.763 no no no no no no Hippuric acid+urine 20:1+blood -0.517156863 0 0 yes urine_cometabolism serum_fattyacid 0.361 2.56E-05 no no no dn dn dn Hippuric acid+urine 20:5/18:0-PC+blood 0 0 0.468831169 urine_cometabolism serum_phospholipids 0.361 3.97E-06 no no no no up up Hippuric acid+urine 3-Hydroxytyramine hydrochloride+urine 0 -0.564912281 0 urine_cometabolism urine_cometabolism 0.361 0.288 no no no no no no Hippuric acid+urine 5-Hydroxyindole-3-acetic Acid+urine -0.627067669 0 0 urine_cometabolism urine_cometabolism 0.361 0.0405 no no no no dn dn Hippuric acid+urine 5-Hydroxytryptamine+urine -0.469172932 -0.6 0 urine_cometabolism urine_cometabolism 0.361 0.171 no no no no no no Hippuric acid+urine 8-HETE+blood 0 0 0.632467532 urine_cometabolism serum_ARA 0.361 0.741 no no no no no no Hippuric acid+urine Adherens junction 0 -0.566666667 -0.476923077 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Adrenergic signaling in cardiomyocytes 0 0 -0.626923077 urine_cometabolism kegg 0.361 NA no no no no no up Hippuric acid+urine AGE-RAGE signaling pathway in diabetic complications 0 0 0.436923077 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Alcoholism 0 0 -0.53 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Aldosterone synthesis and secretion 0 0 -0.605384615 urine_cometabolism kegg 0.361 NA no no no no up up Hippuric acid+urine Allograft rejection 0 -0.457894737 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Alzheimer disease 0 0 -0.596923077 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Amphetamine addiction 0 0 -0.644615385 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine AMPK signaling pathway 0 0.471929825 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Amyotrophic lateral sclerosis 0 0 -0.701538462 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Anaerostipes 0.572079545 0 0 butyrate-producing urine_cometabolism Genus 0.361 0.568 no no no no no no Hippuric acid+urine Antigen processing and presentation 0 -0.729824561 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Apelin signaling pathway 0.557894737 0 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.483846154 urine_cometabolism kegg 0.361 NA no no no no up up Hippuric acid+urine Asthma 0 -0.575438596 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Autoimmune thyroid disease 0 -0.457894737 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Autophagy - animal 0 0 0.461538462 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Bacterial invasion of epithelial cells 0 -0.685964912 -0.463846154 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Breast cancer 0 0.552631579 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine C-type lectin receptor signaling pathway 0 0 0.416923077 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine CA+stool 0 0 -0.661506708 urine_cometabolism stool_bileacids 0.361 0.827 no no no no no no Hippuric acid+urine Carbon metabolism 0 -0.631578947 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Cardiac muscle contraction 0 0 -0.598461538 urine_cometabolism kegg 0.361 NA no no no no no up Hippuric acid+urine CDCA+stool 0 0 -0.591331269 urine_cometabolism stool_bileacids 0.361 0.663 no no no no no no Hippuric acid+urine Chemical carcinogenesis - receptor activation 0 0.659649123 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Choline metabolism in cancer 0 0.629824561 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Circadian entrainment 0 0 -0.806153846 urine_cometabolism kegg 0.361 NA no no no no up up Hippuric acid+urine Clostridium 0 -0.633432613 0 urine_cometabolism Genus 0.361 0.925 no no no no no no Hippuric acid+urine Cocaine addiction 0 0 -0.446153846 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Collinsella 0 0 -0.44611047 urine_cometabolism Genus 0.361 0.128 no no no no no no Hippuric acid+urine Coprococcus 0 0 0.525470085 butyrate-producing urine_cometabolism Genus 0.361 0.612 no no no no no no Hippuric acid+urine Coronavirus disease - COVID-19 0.466666667 0 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Cortisol synthesis and secretion 0 0.522807018 -0.553076923 urine_cometabolism kegg 0.361 NA no no no no no up Hippuric acid+urine Cushing syndrome 0 0.543859649 0 urine_cometabolism kegg 0.361 NA no no no no no up Hippuric acid+urine d18:1-16:1-SM+blood 0 0 -0.438961039 urine_cometabolism serum_phospholipids 0.361 0.2 no no no no no no Hippuric acid+urine d18:1-18:1-SM+blood 0 0 -0.536363636 urine_cometabolism serum_phospholipids 0.361 0.916 no no no no no no Hippuric acid+urine Diabetic cardiomyopathy 0 0 -0.602307692 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Dilated cardiomyopathy 0 0 -0.577692308 urine_cometabolism kegg 0.361 NA no no no no up up Hippuric acid+urine DMG+blood 0 -0.565934066 0 urine_cometabolism serum_choline 0.361 0.909 no no no no no no Hippuric acid+urine Dopaminergic synapse 0 0 -0.69 urine_cometabolism kegg 0.361 NA no no no no up no Hippuric acid+urine EGFR tyrosine kinase inhibitor resistance 0.664912281 0 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Endocrine and other factor-regulated calcium reabsorption 0 0 -0.689230769 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Endocrine resistance 0 0.601754386 -0.422307692 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine EPA+blood 0 0 0.446753247 urine_cometabolism serum_ARA 0.361 0.212 no no no no no no Hippuric acid+urine Epstein-Barr virus infection 0 -0.707017544 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Estrogen signaling pathway 0 0 -0.483846154 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Fluid shear stress and atherosclerosis 0 -0.705263158 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Focal adhesion 0 -0.563157895 -0.478461538 urine_cometabolism kegg 0.361 NA no no no no up up Hippuric acid+urine FoxO signaling pathway 0 0.619298246 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Gap junction 0 0 -0.484615385 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Gastric acid secretion 0 0 -0.54 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Gastric cancer 0.487719298 0.621052632 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine GCDCA+blood 0 0 -0.458441558 urine_cometabolism serum_bileacids 0.361 0.31 no no no no no no Hippuric acid+urine Glucagon signaling pathway 0 0 -0.403846154 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Glycolysis / Gluconeogenesis 0 -0.512280702 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine GnRH signaling pathway 0 0 -0.587692308 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Graft-versus-host disease 0 -0.457894737 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine "Growth hormone synthesis, secretion and action" 0 0.649122807 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine HCA+blood 0 0 -0.547747604 urine_cometabolism serum_bileacids 0.361 0.544 no no no no no no Hippuric acid+urine HDCA+stool 0 0.766666667 0 urine_cometabolism stool_bileacids 0.361 0.176 no no no no no no Hippuric acid+urine Herpes simplex virus 1 infection 0 -0.635087719 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine HIF-1 signaling pathway 0.622807018 0 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Hippo signaling pathway 0 0 -0.467692308 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Human cytomegalovirus infection 0 -0.626315789 0 urine_cometabolism kegg 0.361 NA no no no no no dn Hippuric acid+urine Human immunodeficiency virus 1 infection 0 -0.656140351 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Human T-cell leukemia virus 1 infection 0 -0.661403509 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Huntington disease 0 0 -0.657692308 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Hypertrophic cardiomyopathy 0 -0.473684211 -0.475384615 urine_cometabolism kegg 0.361 NA no no no no up up Hippuric acid+urine Inflammatory mediator regulation of TRP channels 0 0 -0.628461538 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Influenza A 0 -0.564912281 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Insulin secretion 0 0 -0.517692308 yes urine_cometabolism kegg 0.361 NA no no no no up up Hippuric acid+urine Insulin signaling pathway 0.610526316 0 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine JAK-STAT signaling pathway 0 0.533333333 0.427692308 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine L-Aspartic acid+blood 0 0 0.45974026 yes urine_cometabolism serum_aminoacids 0.361 0.0226 no no no up up no Hippuric acid+urine L-Glutamic acid+blood 0 0 0.511688312 yes urine_cometabolism serum_aminoacids 0.361 6.20E-05 no no no up up no Hippuric acid+urine L-Lysine+blood 0 0 0.475324675 yes urine_cometabolism serum_aminoacids 0.361 0.0107 no no no no up no Hippuric acid+urine L-Ornithine+blood 0 0 0.466233766 urine_cometabolism serum_aminoacids 0.361 0.175 no no no no no no Hippuric acid+urine Lachnospira 0 -0.485964912 0 butyrate-producing urine_cometabolism Genus 0.361 0.279 no no no no no no Hippuric acid+urine Leishmaniasis 0 -0.480701754 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Leukocyte transendothelial migration 0 -0.759649123 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Long-term depression 0 0 -0.563846154 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Longevity regulating pathway 0 0.547368421 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Lysosome 0 -0.585964912 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine MAPK signaling pathway 0 0.521052632 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Melanogenesis 0 0 -0.679230769 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Morphine addiction 0 0 -0.68 urine_cometabolism kegg 0.361 NA no no no no up up Hippuric acid+urine mTOR signaling pathway 0.661403509 0 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine n3+blood 0 0 0.515584416 urine_cometabolism serum_fattyacid 0.361 0.806 no no no no no no Hippuric acid+urine Neutrophil extracellular trap formation 0 -0.471929825 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine NF-kappa B signaling pathway 0 0 0.511538462 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine NOD-like receptor signaling pathway 0 0 0.439230769 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Non-alcoholic fatty liver disease 0 0 -0.690769231 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Non-small cell lung cancer 0 0.545614035 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine nutriCA+blood 0 0 -0.481098573 urine_cometabolism serum_bileacids 0.361 0.726 no no no no no no Hippuric acid+urine nutriCA+stool 0 0 -0.554179567 urine_cometabolism stool_bileacids 0.361 0.481 no no no no no no Hippuric acid+urine Oxidative phosphorylation 0 0 -0.64 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Oxytocin signaling pathway 0 -0.6 -0.403846154 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine p53 signaling pathway 0 0.784210526 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Pancreatic secretion 0 0 -0.727692308 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Parabacteroides 0.460150376 0 0 urine_cometabolism Genus 0.361 4.19E-05 no no no no up up Hippuric acid+urine "Parathyroid hormone synthesis, secretion and action" 0 0 -0.505384615 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Parkinson disease 0 0 -0.496153846 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Pathogenic Escherichia coli infection 0 -0.598245614 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Pathways in cancer 0 0.496491228 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Pathways of neurodegeneration - multiple diseases 0 0 -0.460769231 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 0.463076923 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Phagosome 0 -0.519298246 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Phosphatidylinositol signaling system 0 0.547368421 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Platelet activation 0 -0.496491228 -0.555384615 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Platinum drug resistance 0 0.757894737 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Prevotella 0 0.625039386 0 acetate-producing urine_cometabolism Genus 0.361 0.287 no no no no no no Hippuric acid+urine Prion disease 0 0 -0.614615385 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Progesterone-mediated oocyte maturation 0 0.710526316 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Rap1 signaling pathway 0 -0.519298246 -0.533076923 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Ras signaling pathway 0.540350877 0 0 yes urine_cometabolism kegg 0.361 NA no no no no up up Hippuric acid+urine Regulation of actin cytoskeleton 0 -0.594736842 -0.617692308 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Regulation of lipolysis in adipocytes 0 0 -0.553846154 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Renal cell carcinoma 0.49122807 0 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Renin secretion 0 0 -0.646923077 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Retrograde endocannabinoid signaling 0 0 -0.544615385 urine_cometabolism kegg 0.361 NA no no no no no up Hippuric acid+urine Ribosome 0.466666667 0 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine RIG-I-like receptor signaling pathway 0 0 0.417692308 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Salivary secretion 0 0 -0.460769231 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Salmonella infection 0 -0.631578947 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Serotonergic synapse 0 0 -0.424615385 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Signaling pathways regulating pluripotency of stem cells 0 0.584210526 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Spliceosome 0 0.696491228 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Staphylococcus aureus infection 0 -0.584210526 0 urine_cometabolism kegg 0.361 NA no no no up no no Hippuric acid+urine Systemic lupus erythematosus 0 -0.578947368 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine TGF-beta signaling pathway 0.461403509 0 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Thermogenesis 0 0 -0.653076923 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Thyroid hormone synthesis 0 0 -0.433846154 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Tight junction 0 -0.650877193 -0.432307692 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Toxoplasmosis -0.677192982 0 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Tuberculosis 0 -0.489473684 0 urine_cometabolism kegg 0.361 NA no no no no no dn Hippuric acid+urine Vascular smooth muscle contraction 0 0 -0.688461538 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Vasopressin-regulated water reabsorption 0 0 -0.734615385 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Vibrio cholerae infection 0 0 -0.503846154 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Viral myocarditis 0 -0.487719298 0 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Viral protein interaction with cytokine and cytokine receptor 0 -0.459649123 -0.589230769 urine_cometabolism kegg 0.361 NA no no no no no no Hippuric acid+urine Yersinia infection 0 -0.554385965 0 urine_cometabolism kegg 0.361 NA no no no no no no Histidine metabolism Arginine and proline metabolism 0.442608696 0 0 kegg kegg NA NA no no no no up no Histidine metabolism Ascorbate and aldarate metabolism 0.846086957 0.598814229 0.699356499 kegg kegg NA NA no no no no no no Histidine metabolism Citrate cycle (TCA cycle) 0.586956522 0 0.464864865 kegg kegg NA NA no no no no no no Histidine metabolism Fatty acid degradation 0.54 0 0.626254826 kegg kegg NA NA no no no no no no Histidine metabolism Fatty acid elongation 0.650434783 0.423913043 0.484169884 kegg kegg NA NA no no no no no no Histidine metabolism Fructose and mannose metabolism 0.586956522 0 0.597940798 kegg kegg NA NA no no no no no no Histidine metabolism Galactose metabolism 0.768695652 0 0.611068211 kegg kegg NA NA no no no no no no Histidine metabolism Glycolysis / Gluconeogenesis 0.485217391 0 0.616216216 kegg kegg NA NA no no no no no no Histidine metabolism Pentose and glucuronate interconversions 0.493043478 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Primary bile acid biosynthesis 0.679130435 0.427865613 0.565250965 kegg kegg NA NA no no no no no no Histidine metabolism Pyrimidine metabolism 0.652173913 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Steroid biosynthesis 0 0.460474308 0.404633205 kegg kegg NA NA no no no no no no Histidine metabolism Steroid hormone biosynthesis 0.651304348 0.591897233 0.517889318 kegg kegg NA NA no no no no no no Histidine metabolism Synthesis and degradation of ketone bodies 0.499130435 0 0 kegg kegg NA NA no no no no no no Histidine metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.752173913 0.483201581 0 kegg kegg NA NA no no no no no no Histidine metabolism "Valine, leucine and isoleucine degradation" 0.653043478 0.46541502 0.564736165 kegg kegg NA NA no no no no no no Holdemania WAL_1855D 0.402433251 0 0 Genus Genus 0.289 0.916 no no no no no no HOMA-IR+clinic 12-ketoDCA+blood 0 -0.541210939 0 clinic serum_bileacids 1.68E-06 0.517 up up no no no no HOMA-IR+clinic 16:0/18:0-PC+blood 0 -0.517857143 0 clinic serum_phospholipids 1.68E-06 0.521 up up no no no no HOMA-IR+clinic 16:0+blood 0 0 0.441538462 yes clinic serum_fattyacid 1.68E-06 0.00876 up up no up no no HOMA-IR+clinic 16:1+blood 0 0.567857143 0 yes clinic serum_fattyacid 1.68E-06 0.0186 up up no no no dn HOMA-IR+clinic 18:0/20:3-PC+blood 0 0 0.436153846 clinic serum_phospholipids 1.68E-06 0.0682 up up no no up no HOMA-IR+clinic 18:0/20:3-PI+blood 0 0.625 0 clinic serum_phospholipids 1.68E-06 0.377 up up no no no no HOMA-IR+clinic 18:1/18:1-PE+blood 0 0.521428571 0 clinic serum_phospholipids 1.68E-06 1.03E-05 up up no up up no HOMA-IR+clinic 18:2-LPC+blood 0 -0.542857143 -0.413846154 clinic serum_phospholipids 1.68E-06 0.00743 up up no dn no up HOMA-IR+clinic 18:2-LPE+blood 0 0 -0.476153846 clinic serum_phospholipids 1.68E-06 0.112 up up no no no no HOMA-IR+clinic 20:2/18:0-PC+blood 0 0 0.426153846 clinic serum_phospholipids 1.68E-06 0.0427 up up no no up no HOMA-IR+clinic 20:3n6+blood 0 0.557142857 0.454615385 clinic serum_fattyacid 1.68E-06 0.0884 up up no up no no HOMA-IR+clinic 4-hydroxybenzoic acid+urine 0 -0.62254902 -0.485384615 clinic urine_cometabolism 1.68E-06 0.52 up up no no no no HOMA-IR+clinic 9-HODE+blood 0 -0.546428571 0 clinic serum_ARA 1.68E-06 0.297 up up no no no no HOMA-IR+clinic C-peptide 0 0.592320723 0 clinic DM-assocaited hormones 1.68E-06 0.228 up up no no no no HOMA-IR+clinic CDCA+stool 0 0.709090909 0 clinic stool_bileacids 1.68E-06 0.663 up up no no no no HOMA-IR+clinic GLCA+blood 0 0 -0.411408253 clinic serum_bileacids 1.68E-06 0.319 up up no no no no HOMA-IR+clinic GUDCA+stool 0 -0.629285309 0 yes clinic stool_bileacids 1.68E-06 0.0085 up up no no dn no HOMA-IR+clinic HDCA+blood 0 -0.541210939 0 clinic serum_bileacids 1.68E-06 0.483 up up no no no no HOMA-IR+clinic iso-LCA+blood 0 -0.520922988 0 clinic serum_bileacids 1.68E-06 0.507 up up no no no no HOMA-IR+clinic L-Homocystine+blood 0 -0.535714286 0 clinic serum_aminoacids 1.68E-06 0.197 up up no no no no HOMA-IR+clinic L-Proline+blood 0 0.664285714 0 yes clinic serum_aminoacids 1.68E-06 0.00265 up up no up up no HOMA-IR+clinic L-Tyrosine+blood 0 0.689285714 0 yes clinic serum_aminoacids 1.68E-06 0.00913 up up no up up no HOMA-IR+clinic Legionellosis 0 -0.438961039 0 clinic kegg 1.68E-06 NA up up no no no no HOMA-IR+clinic Leptin 0 0 0.506799083 clinic DM-assocaited hormones 1.68E-06 0.706 up up no no no no HOMA-IR+clinic Methanobrevibacter 0 -0.499010879 0 clinic Genus 1.68E-06 0.629 up up no no no no HOMA-IR+clinic Parabacteroides 0 -0.483907397 0 clinic Genus 1.68E-06 4.19E-05 up up no no up up HOMA-IR+clinic Paraprevotella 0 0.5244252 0 clinic Genus 1.68E-06 0.118 up up no no no no HOMA-IR+clinic Roseburia 0 0.532053114 0 butyrate-producing clinic Genus 1.68E-06 0.495 up up no no no no HOMA-IR+clinic total_stool_scfa+stool 0 -0.636363636 0 clinic stool_scfa 1.68E-06 0.0534 up up no dn no up HOMA-¦Â+clinic 13-HODE+blood 0 0 -0.628461538 clinic serum_ARA 3.22E-07 0.32 dn dn no no no no HOMA-¦Â+clinic 18:0/22:6-PC+blood 0.583075335 0 0 clinic serum_phospholipids 3.22E-07 0.0775 dn dn no no no up HOMA-¦Â+clinic 18:1-LPC+blood -0.512899897 0 0 clinic serum_phospholipids 3.22E-07 0.179 dn dn no no no no HOMA-¦Â+clinic 18:1-LPE+blood -0.477812178 0 0 clinic serum_phospholipids 3.22E-07 0.117 dn dn no no no no HOMA-¦Â+clinic 18:2-LPC+blood 0 -0.632142857 0 clinic serum_phospholipids 3.22E-07 0.00743 dn dn no dn no up HOMA-¦Â+clinic 18:2-LPE+blood 0 0 -0.433076923 clinic serum_phospholipids 3.22E-07 0.112 dn dn no no no no HOMA-¦Â+clinic 18:2/18:2-PC+blood 0 -0.696428571 0 clinic serum_phospholipids 3.22E-07 1.98E-05 dn dn no dn up up HOMA-¦Â+clinic 8-HETE+blood 0 0 -0.456153846 clinic serum_ARA 3.22E-07 0.741 dn dn no no no no HOMA-¦Â+clinic Blautia 0 0.653303219 -0.405773877 acetate-producing clinic Genus 3.22E-07 1.36E-05 dn dn no up dn dn HOMA-¦Â+clinic CA+stool 0 0.745454545 0 clinic stool_bileacids 3.22E-07 0.827 dn dn no no no no HOMA-¦Â+clinic Carbon metabolism 0 0.444155844 0 clinic kegg 3.22E-07 NA dn dn no no no no HOMA-¦Â+clinic CDCA+stool 0 0.863636364 0 clinic stool_bileacids 3.22E-07 0.663 dn dn no no no no HOMA-¦Â+clinic Clostridium 0.448727466 0.524145742 0 clinic Genus 3.22E-07 0.925 dn dn no no no no HOMA-¦Â+clinic Collinsella 0.521373873 0 0 clinic Genus 3.22E-07 0.128 dn dn no no no no HOMA-¦Â+clinic Coprococcus 0 0.532467532 0 butyrate-producing clinic Genus 3.22E-07 0.612 dn dn no no no no HOMA-¦Â+clinic d18:1-14:0-SM+blood 0.531475748 0 0 clinic serum_phospholipids 3.22E-07 0.94 dn dn no no no no HOMA-¦Â+clinic Dorea 0 0.613950886 0 clinic Genus 3.22E-07 0.00362 dn dn no up no dn HOMA-¦Â+clinic Faecalibacterium 0 0.457933371 0 butyrate-producing clinic Genus 3.22E-07 0.0039 dn dn no no dn dn HOMA-¦Â+clinic GCA+stool 0 0.763636364 0 clinic stool_bileacids 3.22E-07 0.0809 dn dn no no no no HOMA-¦Â+clinic GCDCA+stool 0.632352941 0.763636364 0 yes clinic stool_bileacids 3.22E-07 0.0471 dn dn no no dn no HOMA-¦Â+clinic GDCA+blood 0 -0.521428571 0 clinic serum_bileacids 3.22E-07 0.632 dn dn no no no no HOMA-¦Â+clinic GDCA+stool 0 0.797268583 0 clinic stool_bileacids 3.22E-07 0.656 dn dn no no no no HOMA-¦Â+clinic GPC+blood 0.500515996 0 0 clinic serum_choline 3.22E-07 0.00427 dn dn no no up up HOMA-¦Â+clinic "Growth hormone synthesis, secretion and action" 0 -0.468831169 0 clinic kegg 3.22E-07 NA dn dn no no no no HOMA-¦Â+clinic Hippuric acid+urine 0 0 -0.412307692 clinic urine_cometabolism 3.22E-07 0.361 dn dn no no no no HOMA-¦Â+clinic IL-1ra 0 0.489473684 0 yes clinic serum_cytokines 3.22E-07 0.0288 dn dn no no up no HOMA-¦Â+clinic Indole-3-Acetic acid+stool 0 -0.790909091 0 clinic stool_cometabolism 3.22E-07 0.304 dn dn no no no no HOMA-¦Â+clinic Indole-3-Acetic acid+urine -0.494324045 0 0 clinic urine_cometabolism 3.22E-07 0.657 dn dn no no no no HOMA-¦Â+clinic iso-LCA+blood 0 -0.552816232 0 clinic serum_bileacids 3.22E-07 0.507 dn dn no no no no HOMA-¦Â+clinic L-Homocystine+blood -0.543859649 0 0 clinic serum_aminoacids 3.22E-07 0.197 dn dn no no no no HOMA-¦Â+clinic L-Methionine+blood 0 0.560714286 0 clinic serum_aminoacids 3.22E-07 0.626 dn dn no no no no HOMA-¦Â+clinic L-Phenylalanine+blood 0 0.65 0 yes clinic serum_aminoacids 3.22E-07 0.0103 dn dn no up up no HOMA-¦Â+clinic L-Proline+blood 0 0.560714286 0 yes clinic serum_aminoacids 3.22E-07 0.00265 dn dn no up up no HOMA-¦Â+clinic L-Tryptophan+blood 0 0.628571429 0 clinic serum_aminoacids 3.22E-07 0.164 dn dn no no no no HOMA-¦Â+clinic L-Tyrosine+blood 0 0.825 0 yes clinic serum_aminoacids 3.22E-07 0.00913 dn dn no up up no HOMA-¦Â+clinic Leptin 0.529644269 0.518915867 0 clinic DM-assocaited hormones 3.22E-07 0.706 dn dn no no no no HOMA-¦Â+clinic Longevity regulating pathway - multiple species 0 0.475324675 0 clinic kegg 3.22E-07 NA dn dn no no no no HOMA-¦Â+clinic PUFA/MUFA+blood 0.525283798 0 0 clinic serum_fattyacid 3.22E-07 0.00108 dn dn no dn no up HOMA-¦Â+clinic Regulation of actin cytoskeleton 0 0.512987013 0 clinic kegg 3.22E-07 NA dn dn no no no no HOMA-¦Â+clinic Roseburia 0 0.455803464 0 butyrate-producing clinic Genus 3.22E-07 0.495 dn dn no no no no HOMA-¦Â+clinic TDCA+blood 0 -0.540058935 0 yes clinic serum_bileacids 3.22E-07 0.155 dn dn no no up no HOMA-¦Â+clinic TXB2+blood 0.524303086 0 0 yes clinic serum_ARA 3.22E-07 0.0644 dn dn no dn no no HOMA-¦Â+clinic UDCA+stool 0 0.881818182 0 clinic stool_bileacids 3.22E-07 0.266 dn dn no no no no HOMA-¦Â+clinic Valine+blood 0 0.578571429 0 yes clinic serum_aminoacids 3.22E-07 1.22E-06 dn dn no up up no Homologous recombination ABC transporters 0.588695652 0.735177866 0 kegg kegg NA NA no no no no up up Homologous recombination Amino sugar and nucleotide sugar metabolism 0.491304348 0.690711462 0 kegg kegg NA NA no no no no no no Homologous recombination Aminoacyl-tRNA biosynthesis 0.708695652 0.694664032 0.663063063 kegg kegg NA NA no no no no no no Homologous recombination Antifolate resistance 0.415652174 0.473320158 0 kegg kegg NA NA no no no no no no Homologous recombination Arginine and proline metabolism 0 0 -0.421621622 kegg kegg NA NA no no no no up no Homologous recombination Ascorbate and aldarate metabolism 0 0 0.445302445 kegg kegg NA NA no no no no no no Homologous recombination Basal transcription factors 0.536521739 0.649209486 0.817760618 kegg kegg NA NA no no no no no no Homologous recombination Base excision repair 0.807826087 0.692687747 0.852509653 kegg kegg NA NA no no no no no no Homologous recombination Biosynthesis of amino acids 0 0 -0.53024453 kegg kegg NA NA no no no no no no Homologous recombination Biosynthesis of cofactors 0 0.467391304 0 kegg kegg NA NA no no no no no no Homologous recombination Biosynthesis of unsaturated fatty acids 0.633913043 0 0.457142857 kegg kegg NA NA no no no no no no Homologous recombination Butanoate metabolism 0.409565217 0 0.594594595 kegg kegg NA NA no no no no no no Homologous recombination Carbon metabolism 0 -0.437747036 0 kegg kegg NA NA no no no no no no Homologous recombination Citrate cycle (TCA cycle) 0.44 0 0.537194337 kegg kegg NA NA no no no no no no Homologous recombination Cysteine and methionine metabolism 0.696521739 0 0.722779923 kegg kegg NA NA no no no no no no Homologous recombination DNA replication 0.762608696 0.479249012 0.779407979 kegg kegg NA NA no no no no no no Homologous recombination EGFR tyrosine kinase inhibitor resistance 0 0 0.408236808 kegg kegg NA NA no no no no no no Homologous recombination Ether lipid metabolism 0 0 0.613384813 kegg kegg NA NA no no no no no no Homologous recombination Fatty acid elongation 0 0 0.412355212 kegg kegg NA NA no no no no no no Homologous recombination Glycerolipid metabolism 0 0.661067194 0 kegg kegg NA NA no no no no no up Homologous recombination Glycerophospholipid metabolism 0 0.754940711 0.551866152 kegg kegg NA NA no no no no no up Homologous recombination Glycosaminoglycan biosynthesis - keratan sulfate -0.429565217 0 0 kegg kegg NA NA no no no no no no Homologous recombination Glycosaminoglycan degradation -0.654782609 0 0 kegg kegg NA NA no no no no no up Homologous recombination Glycosphingolipid biosynthesis - ganglio series 0 0.481225296 0.452252252 kegg kegg NA NA no no no no no no Homologous recombination Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.691304348 0.768774704 0.405920206 kegg kegg NA NA no no no no no no Homologous recombination Inositol phosphate metabolism 0.483478261 0.70256917 0.543371943 kegg kegg NA NA no no no no no no Homologous recombination Lysine degradation 0.409565217 0.71541502 0.546203346 kegg kegg NA NA no no no no no no Homologous recombination Mannose type O-glycan biosynthesis 0 0.470355731 0.425740026 kegg kegg NA NA no no no no no no Homologous recombination Mismatch repair 0.74 0.47826087 0.690862291 kegg kegg NA NA no no no no no no Homologous recombination mRNA surveillance pathway 0 0 0.534105534 kegg kegg NA NA no no no no no no Homologous recombination Mucin type O-glycan biosynthesis 0.693913043 0.527667984 0.543629344 kegg kegg NA NA no no no no no no Homologous recombination N-Glycan biosynthesis 0.513913043 0 0.654568855 kegg kegg NA NA no no no no no no Homologous recombination Nicotinate and nicotinamide metabolism 0 0 -0.531016731 kegg kegg NA NA no no no no no no Homologous recombination Nucleotide excision repair 0.803478261 0.583992095 0.87027027 kegg kegg NA NA no no no no no no Homologous recombination One carbon pool by folate 0.77826087 0.518774704 0.71969112 kegg kegg NA NA no no no no no no Homologous recombination Other glycan degradation 0 0.551383399 0 kegg kegg NA NA no no no no no no Homologous recombination Other types of O-glycan biosynthesis 0.485217391 0.798418972 0.726640927 kegg kegg NA NA no no no no no no Homologous recombination Pentose and glucuronate interconversions 0.423478261 0 0.524581725 kegg kegg NA NA no no no no no no Homologous recombination Pentose phosphate pathway 0 -0.546442688 -0.562419562 kegg kegg NA NA no no no no no no Homologous recombination Platinum drug resistance 0.710434783 0.81027668 0.786357786 kegg kegg NA NA no no no no no no Homologous recombination PPAR signaling pathway 0 0 -0.649163449 kegg kegg NA NA no no no no no no Homologous recombination Primary bile acid biosynthesis 0.664347826 0 0 kegg kegg NA NA no no no no no no Homologous recombination Propanoate metabolism 0.695652174 0 0.653281853 kegg kegg NA NA no no no no no no Homologous recombination Pyrimidine metabolism 0.462608696 0 0 kegg kegg NA NA no no no no no no Homologous recombination Pyruvate metabolism 0.706086957 0 0.611068211 kegg kegg NA NA no no no no no no Homologous recombination Retinol metabolism 0.603478261 0.475296443 0.59021879 kegg kegg NA NA no no no no no no Homologous recombination Ribosome biogenesis in eukaryotes 0.68173913 0.745059289 0.813127413 kegg kegg NA NA no no no no no no Homologous recombination RNA degradation 0 0 0.586357786 kegg kegg NA NA no no no no no no Homologous recombination RNA polymerase 0.504347826 0.612648221 0.685456885 kegg kegg NA NA no no no no no no Homologous recombination RNA transport 0.670434783 0 0.44041184 kegg kegg NA NA no no no no no no Homologous recombination Selenocompound metabolism 0.536521739 0.840909091 0.775032175 kegg kegg NA NA no no no no no no Homologous recombination Sphingolipid metabolism -0.705217391 -0.42687747 0 kegg kegg NA NA no no no no no no Homologous recombination Spliceosome 0.751304348 0.839920949 0.762419562 kegg kegg NA NA no no no no no no Homologous recombination Steroid biosynthesis 0 0 0.628056628 kegg kegg NA NA no no no no no no Homologous recombination Steroid hormone biosynthesis 0 0 0.490604891 kegg kegg NA NA no no no no no no Homologous recombination Synthesis and degradation of ketone bodies 0.732173913 0.564229249 0.700643501 kegg kegg NA NA no no no no no no Homologous recombination Taurine and hypotaurine metabolism 0 0.554347826 0 kegg kegg NA NA no no no no no no Homologous recombination Terpenoid backbone biosynthesis 0.532173913 0.552371542 0.674388674 kegg kegg NA NA no no no no no no Homologous recombination Thiamine metabolism 0.525217391 0 0 kegg kegg NA NA no no no no no no Homologous recombination Tryptophan metabolism 0.431304348 0 0.475418275 kegg kegg NA NA no no no no up no Homologous recombination Tyrosine metabolism 0 0 0.424710425 kegg kegg NA NA no no no no no no Homologous recombination Ubiquinone and other terpenoid-quinone biosynthesis 0.586086957 0.509881423 0.653796654 kegg kegg NA NA no no no no no no Homologous recombination "Valine, leucine and isoleucine degradation" 0.617391304 0 0.642213642 kegg kegg NA NA no no no no no no Homologous recombination Various types of N-glycan biosynthesis 0.43826087 0 0.605920206 kegg kegg NA NA no no no no no no Homovanillic acid+urine 16:0/18:1-PC+blood -0.615196078 0 0 urine_cometabolism serum_phospholipids 0.45 6.15E-07 no no no up up up Homovanillic acid+urine 16:0/18:2-PC+blood -0.524509804 0 0 urine_cometabolism serum_phospholipids 0.45 3.24E-06 no no no no up up Homovanillic acid+urine 16:0/18:2-PI+blood 0.664215686 0 0 urine_cometabolism serum_phospholipids 0.45 0.269 no no no no no no Homovanillic acid+urine 16:0/20:3-PC+blood -0.504901961 -0.642857143 0 urine_cometabolism serum_phospholipids 0.45 5.43E-06 no no no no up up Homovanillic acid+urine 16:0/20:4-PI+blood 0.781862745 0 0 urine_cometabolism serum_phospholipids 0.45 0.558 no no no no no no Homovanillic acid+urine 18:0-LPC+blood 0.534313725 0 0 urine_cometabolism serum_phospholipids 0.45 0.554 no no no no no no Homovanillic acid+urine 18:0-LPE+blood 0.62745098 0 0.464935065 urine_cometabolism serum_phospholipids 0.45 0.491 no no no no no no Homovanillic acid+urine 18:0/16:0-PC+blood -0.571078431 0 0 urine_cometabolism serum_phospholipids 0.45 9.64E-07 no no no up up up Homovanillic acid+urine 18:0/18:2-PC+blood -0.507352941 0 0 urine_cometabolism serum_phospholipids 0.45 1.74E-06 no no no no up up Homovanillic acid+urine 18:0/20:3-PC+blood 0 0 0.438961039 urine_cometabolism serum_phospholipids 0.45 0.0682 no no no no up no Homovanillic acid+urine 18:0/20:5-PC+blood -0.553921569 0 0 urine_cometabolism serum_phospholipids 0.45 0.17 no no no no no no Homovanillic acid+urine 18:1/16:0-PC+blood -0.524509804 0 0 urine_cometabolism serum_phospholipids 0.45 2.43E-05 no no no no up up Homovanillic acid+urine 18:1/18:0-PC+blood -0.556372549 0 0 urine_cometabolism serum_phospholipids 0.45 1.83E-06 no no no no up up Homovanillic acid+urine 18:1/18:1-PC+blood -0.546568627 -0.587912088 0 urine_cometabolism serum_phospholipids 0.45 1.34E-05 no no no no up up Homovanillic acid+urine 18:1/18:2-PG+blood 0 -0.56043956 0 urine_cometabolism serum_phospholipids 0.45 5.58E-07 no no no no up up Homovanillic acid+urine 18:1/20:3-PC+blood 0 -0.576923077 0 urine_cometabolism serum_phospholipids 0.45 0.00872 no no no no up up Homovanillic acid+urine 18:3n3+blood 0 0.604395604 0 urine_cometabolism serum_fattyacid 0.45 0.291 no no no no no no Homovanillic acid+urine 18:3n6+blood 0.492647059 0 0 urine_cometabolism serum_fattyacid 0.45 0.0463 no no no up no dn Homovanillic acid+urine 2-hydroxyphenylacetic acid+urine 0 0.557894737 0 urine_cometabolism urine_cometabolism 0.45 0.763 no no no no no no Homovanillic acid+urine 20:0+blood -0.517156863 -0.576923077 0 yes urine_cometabolism serum_fattyacid 0.45 0.000278 no no no dn no up Homovanillic acid+urine 20:2/18:0-PC+blood 0 0 0.464935065 urine_cometabolism serum_phospholipids 0.45 0.0427 no no no no up no Homovanillic acid+urine 20:3/18:0-PC+blood 0 0 0.435064935 urine_cometabolism serum_phospholipids 0.45 0.296 no no no no no no Homovanillic acid+urine 20:3n6+blood 0 -0.60989011 0 urine_cometabolism serum_fattyacid 0.45 0.0884 no no no up no no Homovanillic acid+urine 22:6n3+blood 0.531862745 0 0 urine_cometabolism serum_fattyacid 0.45 0.792 no no no no no no Homovanillic acid+urine 24:0+blood 0 -0.758241758 0 urine_cometabolism serum_fattyacid 0.45 0.034 no no no dn no up Homovanillic acid+urine 4-hydroxy-3-methoxymandelic acid+urine 0 0 0.662905983 urine_cometabolism urine_cometabolism 0.45 0.973 no no no no no no Homovanillic acid+urine 4-hydroxybenzoic acid+stool 0.538461538 0 0 urine_cometabolism stool_cometabolism 0.45 0.0536 no no no no dn no Homovanillic acid+urine 4-hydroxybenzoic acid+urine 0 0.5 0 urine_cometabolism urine_cometabolism 0.45 0.52 no no no no no no Homovanillic acid+urine "9,10-EPOME+blood" 0 0.737277176 0 urine_cometabolism serum_ARA 0.45 0.801 no no no no no no Homovanillic acid+urine Acetic acid+stool 0.652747253 0 0 yes urine_cometabolism stool_scfa 0.45 0.0656 no no no dn no no Homovanillic acid+urine Acute myeloid leukemia 0 0 -0.436153846 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Alistipes -0.724398412 0 0 urine_cometabolism Genus 0.45 0.0114 no no no no up no Homovanillic acid+urine Anaerostipes 0 0 0.462520223 butyrate-producing urine_cometabolism Genus 0.45 0.568 no no no no no no Homovanillic acid+urine Biosynthesis of amino acids 0 0.573684211 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Breast cancer 0 0 -0.447692308 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Carbon metabolism 0 0.540350877 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Central carbon metabolism in cancer 0.514035088 0 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Chemokine signaling pathway -0.470175439 0 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Clostridium 0 0.531354264 0 urine_cometabolism Genus 0.45 0.925 no no no no no no Homovanillic acid+urine Colorectal cancer 0 -0.503508772 -0.425384615 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Coprococcus 0.448120301 0 0 butyrate-producing urine_cometabolism Genus 0.45 0.612 no no no no no no Homovanillic acid+urine Cytosolic DNA-sensing pathway -0.59122807 0 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine d18:1-18:1-SM+blood 0 0.697802198 0 urine_cometabolism serum_phospholipids 0.45 0.916 no no no no no no Homovanillic acid+urine d18:1-20:1-SM+blood 0 0.56043956 0 urine_cometabolism serum_phospholipids 0.45 0.0992 no no no no no no Homovanillic acid+urine Ethanolamine+blood 0 0 -0.501298701 urine_cometabolism serum_aminoacids 0.45 0.122 no no no up no no Homovanillic acid+urine Fc gamma R-mediated phagocytosis 0 0.503508772 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine GABAergic synapse 0.477192982 0 0 urine_cometabolism kegg 0.45 NA no no no no up up Homovanillic acid+urine Gastric cancer 0 -0.507017544 -0.473076923 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine GCA+stool 0 0 0.502579979 urine_cometabolism stool_bileacids 0.45 0.0809 no no no no no no Homovanillic acid+urine GDCA+blood 0 0 -0.461038961 urine_cometabolism serum_bileacids 0.45 0.632 no no no no no no Homovanillic acid+urine Gemmiger 0 0 -0.567124119 butyrate-producing urine_cometabolism Genus 0.45 0.595 no no no no no no Homovanillic acid+urine GLCA+blood 0 0 -0.507098955 urine_cometabolism serum_bileacids 0.45 0.319 no no no no no no Homovanillic acid+urine Hypotaurine+blood 0 0 -0.616883117 urine_cometabolism serum_aminoacids 0.45 0.933 no no no no no no Homovanillic acid+urine Influenza A -0.556140351 0 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine iso-LCA+blood 0 0 -0.468140838 urine_cometabolism serum_bileacids 0.45 0.507 no no no no no no Homovanillic acid+urine L-Glutamine+blood -0.495098039 0 0 urine_cometabolism serum_aminoacids 0.45 0.639 no no no no no no Homovanillic acid+urine L-Homocystine+blood 0 0 -0.479220779 urine_cometabolism serum_aminoacids 0.45 0.197 no no no no no no Homovanillic acid+urine L-Methionine+blood 0 0 -0.433766234 urine_cometabolism serum_aminoacids 0.45 0.626 no no no no no no Homovanillic acid+urine L-Phenylalanine+stool 0 0.75 0 urine_cometabolism stool_cometabolism 0.45 0.398 no no no no no no Homovanillic acid+urine L-Tryptophan+blood 0 0 -0.511688312 urine_cometabolism serum_aminoacids 0.45 0.164 no no no no no no Homovanillic acid+urine L-Tryptophan+stool 0 0.7 0 urine_cometabolism stool_cometabolism 0.45 0.557 no no no no no no Homovanillic acid+urine L-Tyrosine+blood 0 0 -0.454545455 yes urine_cometabolism serum_aminoacids 0.45 0.00913 no no no up up no Homovanillic acid+urine LCA+blood 0 0 -0.564197877 urine_cometabolism serum_bileacids 0.45 0.884 no no no no no no Homovanillic acid+urine Legionellosis 0 0 0.456923077 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Leishmaniasis 0 0 0.466923077 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Longevity regulating pathway - multiple species 0.529824561 0 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Lysosome 0 0.496491228 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine MAPK signaling pathway 0.471929825 0 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine MUFA%+blood -0.536764706 0 0 urine_cometabolism serum_fattyacid 0.45 0.00142 no no no up no dn Homovanillic acid+urine Non-small cell lung cancer 0 0 -0.520769231 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Odoribacter 0 0 -0.438394057 butyrate-producing urine_cometabolism Genus 0.45 0.798 no no no no no no Homovanillic acid+urine Olfactory transduction 0 0.542105263 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Oscillospira -0.44962406 0 0 LPS-producing urine_cometabolism Genus 0.45 0.62 no no no no no no Homovanillic acid+urine p53 signaling pathway 0 -0.505263158 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Peroxisome 0.526315789 0 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Phenylacetic acid+stool -0.718681319 0 0 urine_cometabolism stool_cometabolism 0.45 0.785 no no no no no no Homovanillic acid+urine Primary immunodeficiency 0.494736842 0 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Propionic acid+stool 0.67032967 0 0 yes urine_cometabolism stool_scfa 0.45 0.0436 no no no dn no up Homovanillic acid+urine PUFA/MUFA+blood -0.558823529 0 0 urine_cometabolism serum_fattyacid 0.45 0.00108 no no no dn no up Homovanillic acid+urine PUFA%+blood -0.696078431 0 0 urine_cometabolism serum_fattyacid 0.45 0.0013 no no no dn no up Homovanillic acid+urine Pyramidobacter 0 0 -0.417838231 urine_cometabolism Genus 0.45 0.45 no no no no no no Homovanillic acid+urine Serine+blood -0.485294118 0 0 urine_cometabolism serum_aminoacids 0.45 0.942 no no no no no no Homovanillic acid+urine SFA%+blood -0.723039216 0 0 urine_cometabolism serum_fattyacid 0.45 0.0236 no no no no up no Homovanillic acid+urine Signaling pathways regulating pluripotency of stem cells 0 0 -0.443846154 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine Systemic lupus erythematosus 0 0.456140351 0 urine_cometabolism kegg 0.45 NA no no no no no no Homovanillic acid+urine total_stool_scfa+stool 0.613186813 0 0 urine_cometabolism stool_scfa 0.45 0.0534 no no no dn no up Homovanillic acid+urine Tuberculosis 0 0.484210526 0 urine_cometabolism kegg 0.45 NA no no no no no dn Homovanillic acid+urine TXB2+blood 0 0.563544513 0 yes urine_cometabolism serum_ARA 0.45 0.0644 no no no dn no no Homovanillic acid+urine UDCA+stool 0 0 0.545923633 urine_cometabolism stool_bileacids 0.45 0.266 no no no no no no Homovanillic acid+urine UFA%+blood -0.600490196 0 0 urine_cometabolism serum_fattyacid 0.45 0.0236 no no no no dn no Human cytomegalovirus infection ABC transporters 0 -0.464426877 0 kegg kegg NA NA no no dn no up up Human cytomegalovirus infection Alcoholism 0.580869565 0.443675889 0.527927928 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Amino sugar and nucleotide sugar metabolism 0 -0.510869565 -0.532561133 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Aminoacyl-tRNA biosynthesis 0 -0.567193676 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Anaerostipes 0.427613883 0 0 butyrate-producing kegg Genus NA 0.568 no no dn no no no Human cytomegalovirus infection Antifolate resistance -0.662608696 -0.697628458 -0.516344916 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Antigen processing and presentation 0.933043478 0.93972332 0.879021879 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Apoptosis - multiple species 0 -0.518774704 -0.56010296 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Ascorbate and aldarate metabolism -0.416521739 0 -0.402059202 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Axon guidance 0.568695652 0.536561265 0.416988417 kegg kegg NA NA no no dn no up up Human cytomegalovirus infection Basal transcription factors 0 0 -0.428828829 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Base excision repair 0 -0.568181818 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Biosynthesis of cofactors 0 -0.489130435 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Carbohydrate digestion and absorption 0 0 -0.454311454 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Cell adhesion molecules 0.435652174 0.517786561 0.694723295 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Cell cycle 0 -0.536561265 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Cellular senescence 0.629565217 0.501976285 0.674131274 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Chagas disease 0 0 0.434749035 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Chemokine signaling pathway 0 0 0.45045045 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Cholesterol metabolism 0.510434783 0.518774704 0 yes kegg kegg NA NA no no dn no no up Human cytomegalovirus infection Complement and coagulation cascades 0 0 0.446589447 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Cortisol synthesis and secretion 0 -0.488142292 0 kegg kegg NA NA no no dn no no up Human cytomegalovirus infection Cushing syndrome 0 -0.496047431 0 kegg kegg NA NA no no dn no no up Human cytomegalovirus infection Cytosolic DNA-sensing pathway 0 0 0.493951094 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Desulfovibrio 0 0.422326513 0 kegg Genus NA 0.27 no no dn no no no Human cytomegalovirus infection Endocrine resistance -0.472173913 -0.576086957 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Endocytosis 0.564347826 0.54743083 0.694465894 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Epithelial cell signaling in Helicobacter pylori infection 0 0.427865613 0.629086229 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Fanconi anemia pathway 0 -0.683794466 -0.432175032 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection FoxO signaling pathway 0 0 -0.475160875 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Fructose and mannose metabolism 0 -0.549407115 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Glycerolipid metabolism -0.439130435 -0.548418972 -0.428571429 kegg kegg NA NA no no dn no no up Human cytomegalovirus infection Glycerophospholipid metabolism -0.733043478 -0.616600791 -0.508880309 kegg kegg NA NA no no dn no no up Human cytomegalovirus infection "Glycine, serine and threonine metabolism" 0 -0.457509881 0 kegg kegg NA NA no no dn no up no Human cytomegalovirus infection Glycosphingolipid biosynthesis - ganglio series 0 0 -0.475418275 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.422608696 -0.567193676 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection GnRH secretion 0 0 -0.44015444 kegg kegg NA NA no no dn no up up Human cytomegalovirus infection "Growth hormone synthesis, secretion and action" 0 -0.414031621 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Hedgehog signaling pathway -0.464347826 -0.697628458 -0.502187902 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Hepatitis C 0.416521739 0 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Histidine metabolism -0.423478261 0 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Homologous recombination 0 -0.571146245 -0.455083655 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection IL-17 signaling pathway 0 0.420948617 0.461518662 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Inositol phosphate metabolism -0.603478261 -0.561264822 -0.691377091 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection JAK-STAT signaling pathway 0 0 -0.436550837 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Leukocyte transendothelial migration 0 0.497035573 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Lysine degradation 0 -0.639328063 -0.476705277 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Lysosome 0 0.538537549 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Mannose type O-glycan biosynthesis 0 -0.466403162 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection MAPK signaling pathway 0 -0.503952569 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Maturity onset diabetes of the young 0 -0.450592885 0 kegg kegg NA NA no no dn no up no Human cytomegalovirus infection Natural killer cell mediated cytotoxicity 0.635652174 0.559288538 0.725353925 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Neuroactive ligand-receptor interaction 0 0.550395257 0 kegg kegg NA NA no no dn up up up Human cytomegalovirus infection Neutrophil extracellular trap formation 0 0.428853755 0.467953668 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Nicotine addiction 0 -0.612648221 0 kegg kegg NA NA no no dn no up up Human cytomegalovirus infection Notch signaling pathway 0 -0.4743083 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Nucleotide excision repair 0 0 -0.42033462 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection One carbon pool by folate -0.453043478 -0.572134387 -0.495752896 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Oscillospira 0 -0.416007905 0 LPS-producing kegg Genus NA 0.62 no no dn no no no Human cytomegalovirus infection Osteoclast differentiation 0 0 0.419047619 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Other types of O-glycan biosynthesis 0 -0.640316206 -0.565250965 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Ovarian steroidogenesis -0.426086957 0 0 kegg kegg NA NA no no dn no up up Human cytomegalovirus infection p53 signaling pathway 0 -0.445652174 -0.453796654 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Pathogenic Escherichia coli infection 0 0.494071146 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Pentose phosphate pathway 0 0.416996047 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Pertussis 0 0.444664032 0.491119691 kegg kegg NA NA no no dn no no dn Human cytomegalovirus infection Phagosome 0.423478261 0.537549407 0.605148005 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Phenylalanine metabolism 0 0 -0.475418275 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Phosphatidylinositol signaling system 0 0 -0.483140283 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Platinum drug resistance 0 -0.585968379 -0.595366795 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection PPAR signaling pathway 0.487826087 0 0.602059202 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Progesterone-mediated oocyte maturation 0 -0.588932806 -0.411583012 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Purine metabolism 0 -0.475296443 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Regulation of actin cytoskeleton 0.474782609 0 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Renin-angiotensin system 0 0.528656126 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Retinol metabolism 0 -0.456521739 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Ribosome biogenesis in eukaryotes 0 -0.5256917 -0.409266409 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Salmonella infection 0 0.448616601 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Selenocompound metabolism -0.433913043 -0.694664032 -0.555984556 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Signaling pathways regulating pluripotency of stem cells 0 0 -0.463835264 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Sphingolipid signaling pathway 0 0.539525692 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Spliceosome 0 -0.486166008 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Staphylococcus aureus infection 0 0.489130435 0 kegg kegg NA NA no no dn up no no Human cytomegalovirus infection Steroid biosynthesis -0.410434783 0 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Taste transduction 0 -0.533596838 -0.610553411 kegg kegg NA NA no no dn no no up Human cytomegalovirus infection Taurine and hypotaurine metabolism -0.43826087 -0.543478261 -0.402316602 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Toll-like receptor signaling pathway 0 0 0.461776062 yes kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Tuberculosis 0 0.46541502 0 kegg kegg NA NA no no dn no no dn Human cytomegalovirus infection Type I diabetes mellitus 0.42173913 0.52173913 0.685199485 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.459486166 -0.401801802 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Viral protein interaction with cytokine and cytokine receptor 0.519130435 0 0.451222651 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Vitamin digestion and absorption -0.414782609 -0.455533597 0 kegg kegg NA NA no no dn no no no Human cytomegalovirus infection Yersinia infection 0 0.43972332 0 kegg kegg NA NA no no dn no no no Human immunodeficiency virus 1 infection ABC transporters 0 -0.48715415 0 kegg kegg NA NA no no no no up up Human immunodeficiency virus 1 infection Alcoholism 0.580869565 0 0.425482625 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Amino sugar and nucleotide sugar metabolism 0 -0.505928854 -0.404118404 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Aminoacyl-tRNA biosynthesis 0 -0.509881423 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Antifolate resistance -0.667826087 -0.688735178 -0.416216216 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Antigen processing and presentation 0.931304348 0.958498024 0.895752896 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Apoptosis - multiple species 0 -0.5256917 -0.508622909 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Ascorbate and aldarate metabolism -0.409565217 0 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Axon guidance 0.575652174 0.53458498 0 kegg kegg NA NA no no no no up up Human immunodeficiency virus 1 infection Base excision repair 0 -0.549407115 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Biosynthesis of amino acids 0 0 0.400514801 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Biosynthesis of cofactors 0 -0.476284585 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Cell adhesion molecules 0 0.515810277 0.655341055 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Cell cycle 0 -0.495059289 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Cellular senescence 0.573043478 0.480237154 0.65971686 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Cholesterol metabolism 0.524347826 0.540513834 0 yes kegg kegg NA NA no no no no no up Human immunodeficiency virus 1 infection Cortisol synthesis and secretion 0 -0.506916996 0 kegg kegg NA NA no no no no no up Human immunodeficiency virus 1 infection Cushing syndrome -0.419130435 -0.500988142 0 kegg kegg NA NA no no no no no up Human immunodeficiency virus 1 infection Cytosolic DNA-sensing pathway 0 0 0.423423423 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Desulfovibrio 0 0.422326513 0 kegg Genus NA 0.27 no no no no no no Human immunodeficiency virus 1 infection Endocrine resistance -0.492173913 -0.605731225 -0.441956242 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Endocytosis 0.508695652 0.535573123 0.691891892 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Epithelial cell signaling in Helicobacter pylori infection 0 0 0.561904762 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Epstein-Barr virus infection 0.979130435 0.990118577 0.971943372 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Fanconi anemia pathway 0 -0.651185771 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection FoxO signaling pathway 0 0 -0.432175032 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Fructose and mannose metabolism 0 -0.571146245 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Glycerolipid metabolism -0.429565217 -0.578063241 0 kegg kegg NA NA no no no no no up Human immunodeficiency virus 1 infection Glycerophospholipid metabolism -0.668695652 -0.639328063 -0.420592021 kegg kegg NA NA no no no no no up Human immunodeficiency virus 1 infection "Glycine, serine and threonine metabolism" 0 -0.46541502 0 kegg kegg NA NA no no no no up no Human immunodeficiency virus 1 infection Glycosphingolipid biosynthesis - ganglio series 0 0 -0.428056628 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.571146245 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection GnRH secretion 0 0 -0.406692407 kegg kegg NA NA no no no no up up Human immunodeficiency virus 1 infection "Growth hormone synthesis, secretion and action" 0 -0.471343874 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Hedgehog signaling pathway -0.419130435 -0.663043478 -0.444787645 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Hepatitis C 0.46173913 0 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Herpes simplex virus 1 infection 0.942608696 0.962450593 0.919176319 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Homologous recombination 0 -0.559288538 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Human cytomegalovirus infection 0.983478261 0.995059289 0.967310167 kegg kegg NA NA no no no no no dn Human immunodeficiency virus 1 infection Human papillomavirus infection 0.473043478 0.424901186 0.5997426 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Human T-cell leukemia virus 1 infection 0.952173913 0.98715415 0.934105534 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection IL-17 signaling pathway 0 0 0.458172458 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Inositol phosphate metabolism -0.577391304 -0.568181818 -0.61029601 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Insulin secretion -0.436521739 0 0 yes kegg kegg NA NA no no no no up up Human immunodeficiency virus 1 infection Kaposi sarcoma-associated herpesvirus infection 0 0.518774704 0 kegg kegg NA NA no no no no no dn Human immunodeficiency virus 1 infection Leukocyte transendothelial migration 0 0.513833992 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Lysine degradation 0 -0.619565217 -0.411840412 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Lysosome 0 0.524703557 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Mannose type O-glycan biosynthesis 0 -0.447628458 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection MAPK signaling pathway 0 -0.504940711 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Maturity onset diabetes of the young 0 -0.422924901 0 kegg kegg NA NA no no no no up no Human immunodeficiency virus 1 infection Natural killer cell mediated cytotoxicity 0.56 0.542490119 0.736679537 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Neuroactive ligand-receptor interaction 0 0.526679842 0 kegg kegg NA NA no no no up up up Human immunodeficiency virus 1 infection Neutrophil extracellular trap formation 0 0 0.451480051 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Nicotine addiction 0 -0.638339921 0 kegg kegg NA NA no no no no up up Human immunodeficiency virus 1 infection Notch signaling pathway 0 -0.5 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection One carbon pool by folate -0.414782609 -0.529644269 -0.418018018 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Other types of O-glycan biosynthesis 0 -0.643280632 -0.483397683 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Ovarian steroidogenesis -0.486956522 0 0 kegg kegg NA NA no no no no up up Human immunodeficiency virus 1 infection p53 signaling pathway 0 -0.471343874 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Pathogenic Escherichia coli infection 0 0.475296443 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Pertussis 0 0.420948617 0.443758044 kegg kegg NA NA no no no no no dn Human immunodeficiency virus 1 infection Phagosome 0 0.520750988 0.587129987 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Phenylalanine metabolism 0 0 -0.474646075 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Phosphatidylinositol signaling system 0 0 -0.418018018 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Phototransduction 0 0.433794466 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Platinum drug resistance 0 -0.588932806 -0.537966538 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection PPAR signaling pathway 0.470434783 0 0.542857143 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Progesterone-mediated oocyte maturation 0 -0.583992095 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Proteasome 0 0 0.505019305 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Purine metabolism 0 -0.469367589 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Ras signaling pathway 0.409565217 0 0 yes kegg kegg NA NA no no no no up up Human immunodeficiency virus 1 infection Regulation of actin cytoskeleton 0.406956522 0 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Renin-angiotensin system 0 0.501976285 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Retinol metabolism 0 -0.42687747 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Ribosome biogenesis in eukaryotes 0 -0.479249012 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Salmonella infection 0 0.461462451 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Selenocompound metabolism 0 -0.68083004 -0.42985843 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Signaling pathways regulating pluripotency of stem cells 0 0 -0.465637066 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Sphingolipid signaling pathway 0 0.5256917 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Spliceosome 0 -0.479249012 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Staphylococcus aureus infection 0 0.4743083 0 kegg kegg NA NA no no no up no no Human immunodeficiency virus 1 infection Taste transduction 0 -0.495059289 -0.53024453 kegg kegg NA NA no no no no no up Human immunodeficiency virus 1 infection Taurine and hypotaurine metabolism 0 -0.576086957 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Tuberculosis 0 0.446640316 0 kegg kegg NA NA no no no no no dn Human immunodeficiency virus 1 infection Type I diabetes mellitus 0 0.52173913 0.67001287 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Viral protein interaction with cytokine and cytokine receptor 0.430434783 0 0 kegg kegg NA NA no no no no no no Human immunodeficiency virus 1 infection Vitamin digestion and absorption 0 -0.45256917 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Adrenergic signaling in cardiomyocytes 0 -0.447628458 0 kegg kegg NA NA no no no no no up Human papillomavirus infection African trypanosomiasis 0 0.488142292 0 kegg kegg NA NA no no no no no no Human papillomavirus infection AGE-RAGE signaling pathway in diabetic complications 0 0.491106719 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Aldosterone synthesis and secretion 0 -0.576086957 0 kegg kegg NA NA no no no no up up Human papillomavirus infection Aldosterone-regulated sodium reabsorption 0 0.435770751 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Alzheimer disease -0.509565217 -0.438735178 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Amino sugar and nucleotide sugar metabolism 0 0 -0.634749035 kegg kegg NA NA no no no no no no Human papillomavirus infection Amoebiasis 0.516521739 0.536561265 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Amphetamine addiction -0.453043478 -0.723320158 0 kegg kegg NA NA no no no no no no Human papillomavirus infection AMPK signaling pathway 0 -0.527667984 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Amyotrophic lateral sclerosis -0.517391304 -0.450592885 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Antifolate resistance 0 0 -0.436293436 kegg kegg NA NA no no no no no no Human papillomavirus infection Antigen processing and presentation 0.557391304 0 0.439382239 kegg kegg NA NA no no no no no no Human papillomavirus infection Apelin signaling pathway -0.450434783 -0.578063241 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Apoptosis 0.53826087 0.814229249 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Apoptosis - multiple species 0 0 -0.601544402 kegg kegg NA NA no no no no no no Human papillomavirus infection Ascorbate and aldarate metabolism -0.47826087 0 -0.501930502 kegg kegg NA NA no no no no no no Human papillomavirus infection Autophagy - animal 0 0.43972332 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Autophagy - other -0.430434783 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection B cell receptor signaling pathway 0 0.617588933 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Basal transcription factors -0.666956522 -0.552371542 -0.498326898 kegg kegg NA NA no no no no no no Human papillomavirus infection Base excision repair 0 -0.458498024 -0.555727156 kegg kegg NA NA no no no no no no Human papillomavirus infection beta-Alanine metabolism 0 0 -0.430888031 kegg kegg NA NA no no no no no no Human papillomavirus infection Biosynthesis of amino acids 0.64 0.554347826 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Biosynthesis of cofactors 0 -0.833992095 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Biosynthesis of unsaturated fatty acids 0 0 -0.43989704 kegg kegg NA NA no no no no no no Human papillomavirus infection Butanoate metabolism 0 -0.568181818 -0.476962677 kegg kegg NA NA no no no no no no Human papillomavirus infection C-type lectin receptor signaling pathway 0 0.692687747 0.401544402 kegg kegg NA NA no no no no no no Human papillomavirus infection cAMP signaling pathway 0 0.434782609 0 yes kegg kegg NA NA no no no no up up Human papillomavirus infection Carbohydrate digestion and absorption 0 0.466403162 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Carbon metabolism 0.451304348 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Cardiac muscle contraction -0.440869565 0 0 kegg kegg NA NA no no no no no up Human papillomavirus infection Cell adhesion molecules 0.896521739 0.862648221 0.815958816 kegg kegg NA NA no no no no no no Human papillomavirus infection Cell cycle -0.615652174 -0.597826087 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Cellular senescence 0.960869565 0.982213439 0.950579151 kegg kegg NA NA no no no no no no Human papillomavirus infection cGMP-PKG signaling pathway 0 0.508893281 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Chagas disease 0 0.610671937 0.642213642 kegg kegg NA NA no no no no no no Human papillomavirus infection Chemokine signaling pathway 0 0.506916996 0.584298584 kegg kegg NA NA no no no no no no Human papillomavirus infection Cholesterol metabolism 0 0.485177866 0 yes kegg kegg NA NA no no no no no up Human papillomavirus infection Circadian entrainment 0 -0.531620553 0 kegg kegg NA NA no no no no up up Human papillomavirus infection Citrate cycle (TCA cycle) 0 -0.530632411 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Complement and coagulation cascades 0.699130435 0.543478261 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Cortisol synthesis and secretion 0 -0.432806324 0 kegg kegg NA NA no no no no no up Human papillomavirus infection Cushing syndrome 0 -0.520750988 0 kegg kegg NA NA no no no no no up Human papillomavirus infection Cysteine and methionine metabolism 0 -0.605731225 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Cytosolic DNA-sensing pathway 0 0.480237154 0.627541828 kegg kegg NA NA no no no no no no Human papillomavirus infection DNA replication -0.436521739 -0.56916996 -0.417245817 kegg kegg NA NA no no no no no no Human papillomavirus infection Dopaminergic synapse 0 -0.586956522 0 kegg kegg NA NA no no no no up no Human papillomavirus infection Drug metabolism - cytochrome P450 0 -0.533596838 0 kegg kegg NA NA no no no no no no Human papillomavirus infection ECM-receptor interaction 0 -0.45256917 0 kegg kegg NA NA no no no no up up Human papillomavirus infection EGFR tyrosine kinase inhibitor resistance 0 -0.485177866 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Endocrine and other factor-regulated calcium reabsorption 0 -0.449604743 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Endocytosis 0.95826087 0.880434783 0.926640927 kegg kegg NA NA no no no no no no Human papillomavirus infection Epithelial cell signaling in Helicobacter pylori infection 0.48 0.678853755 0.691891892 kegg kegg NA NA no no no no no no Human papillomavirus infection Estrogen signaling pathway 0 -0.645256917 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Ether lipid metabolism -0.648695652 -0.662055336 -0.489317889 kegg kegg NA NA no no no no no no Human papillomavirus infection Fanconi anemia pathway -0.466086957 -0.486166008 -0.486743887 kegg kegg NA NA no no no no no no Human papillomavirus infection Fatty acid elongation 0 0 -0.405405405 kegg kegg NA NA no no no no no no Human papillomavirus infection Fc epsilon RI signaling pathway 0 0.736166008 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Fc gamma R-mediated phagocytosis 0 0.498023715 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Folate biosynthesis -0.415652174 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection FoxO signaling pathway 0 0 -0.423423423 kegg kegg NA NA no no no no no no Human papillomavirus infection Galactose metabolism 0 0.455533597 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Glucagon signaling pathway 0 -0.646245059 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Glutathione metabolism 0 -0.643280632 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Glycerophospholipid metabolism -0.566956522 0 0 kegg kegg NA NA no no no no no up Human papillomavirus infection "Glycine, serine and threonine metabolism" 0 -0.695652174 0 kegg kegg NA NA no no no no up no Human papillomavirus infection Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.480869565 0.568181818 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Glycosaminoglycan degradation 0 0.545454545 0 kegg kegg NA NA no no no no no up Human papillomavirus infection Glycosphingolipid biosynthesis - ganglio series -0.453043478 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.46541502 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.59486166 0 kegg kegg NA NA no no no no no no Human papillomavirus infection GnRH secretion 0 0.415019763 0 kegg kegg NA NA no no no no up up Human papillomavirus infection GnRH signaling pathway 0 -0.42687747 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Hedgehog signaling pathway -0.471304348 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Hepatitis B 0 0.479249012 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Hepatitis C 0 0.505928854 0.411583012 kegg kegg NA NA no no no no no no Human papillomavirus infection Histidine metabolism 0 0 -0.452252252 kegg kegg NA NA no no no no no no Human papillomavirus infection Homologous recombination 0 0 -0.598198198 kegg kegg NA NA no no no no no no Human papillomavirus infection Human cytomegalovirus infection 0.536521739 0.446640316 0.633204633 kegg kegg NA NA no no no no no dn Human papillomavirus infection Huntington disease -0.544347826 -0.431818182 0 kegg kegg NA NA no no no no no no Human papillomavirus infection IL-17 signaling pathway 0 0.540513834 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Inflammatory mediator regulation of TRP channels 0 -0.4743083 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Influenza A 0.426086957 0.585968379 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Insulin resistance 0 0.507905138 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Insulin signaling pathway -0.471304348 -0.556324111 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Leukocyte transendothelial migration 0.584347826 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Long-term potentiation 0 -0.612648221 0 kegg kegg NA NA no no no no no up Human papillomavirus infection Lysosome 0 0.565217391 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Maturity onset diabetes of the young 0 -0.544466403 0 kegg kegg NA NA no no no no up no Human papillomavirus infection Melanogenesis 0 -0.45256917 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Metabolism of xenobiotics by cytochrome P450 0 -0.468379447 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Mismatch repair 0 -0.716403162 -0.433462033 kegg kegg NA NA no no no no no no Human papillomavirus infection Mitophagy - animal 0 -0.456521739 0 kegg kegg NA NA no no no no no no Human papillomavirus infection mRNA surveillance pathway -0.659130435 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection mTOR signaling pathway 0 -0.496047431 0 kegg kegg NA NA no no no no no no Human papillomavirus infection N-Glycan biosynthesis -0.431304348 -0.499011858 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Natural killer cell mediated cytotoxicity 0.936521739 0.932806324 0.892406692 kegg kegg NA NA no no no no no no Human papillomavirus infection Neuroactive ligand-receptor interaction 0 0.509881423 0 kegg kegg NA NA no no no up up up Human papillomavirus infection Neurotrophin signaling pathway 0 0.636363636 0.47953668 kegg kegg NA NA no no no no no no Human papillomavirus infection Neutrophil extracellular trap formation 0.56173913 0.564229249 0 kegg kegg NA NA no no no no no no Human papillomavirus infection NF-kappa B signaling pathway 0 0.530632411 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Nicotinate and nicotinamide metabolism 0 0.509881423 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Nitrogen metabolism 0.527826087 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection NOD-like receptor signaling pathway 0 0.62944664 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Non-alcoholic fatty liver disease -0.485217391 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Non-homologous end-joining 0 -0.432806324 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Nucleotide excision repair -0.465217391 -0.686758893 -0.638352638 kegg kegg NA NA no no no no no no Human papillomavirus infection One carbon pool by folate -0.486086957 -0.647233202 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Oocyte meiosis -0.492173913 -0.506916996 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Osteoclast differentiation 0 0.668972332 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Other types of O-glycan biosynthesis -0.619130435 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Oxidative phosphorylation -0.488695652 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection p53 signaling pathway -0.487826087 0 -0.492406692 kegg kegg NA NA no no no no no no Human papillomavirus infection "Parathyroid hormone synthesis, secretion and action" 0 -0.455533597 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Parkinson disease -0.406956522 -0.415019763 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Pathogenic Escherichia coli infection 0.572173913 0.648221344 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Pathways of neurodegeneration - multiple diseases -0.413913043 -0.446640316 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Pentose and glucuronate interconversions 0 -0.529644269 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Pentose phosphate pathway 0.576521739 0.588932806 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Pertussis 0.544347826 0.610671937 0 kegg kegg NA NA no no no no no dn Human papillomavirus infection Phagosome 0.886086957 0.795454545 0.675933076 kegg kegg NA NA no no no no no no Human papillomavirus infection Phenylalanine metabolism 0 -0.445652174 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Phosphatidylinositol signaling system -0.48 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Phospholipase D signaling pathway 0 0.530632411 0 kegg kegg NA NA no no no no up up Human papillomavirus infection Platinum drug resistance 0 0 -0.595109395 kegg kegg NA NA no no no no no no Human papillomavirus infection Porphyrin and chlorophyll metabolism 0 -0.675889328 0 kegg kegg NA NA no no no no no no Human papillomavirus infection PPAR signaling pathway 0 0.554347826 0.507593308 kegg kegg NA NA no no no no no no Human papillomavirus infection Primary bile acid biosynthesis 0 -0.414031621 -0.407722008 kegg kegg NA NA no no no no no no Human papillomavirus infection Prion disease -0.446956522 -0.460474308 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Prolactin signaling pathway 0 0.647233202 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Propanoate metabolism 0 -0.603754941 -0.430888031 kegg kegg NA NA no no no no no no Human papillomavirus infection Protein digestion and absorption 0 0.471343874 0 yes kegg kegg NA NA no no no no up up Human papillomavirus infection Protein export -0.639130435 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Protein processing in endoplasmic reticulum 0 -0.557312253 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Proximal tubule bicarbonate reclamation 0 -0.610671937 -0.428571429 kegg kegg NA NA no no no no no no Human papillomavirus infection Purine metabolism 0 -0.621541502 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Pyrimidine metabolism 0 -0.530632411 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Pyruvate metabolism 0 -0.674901186 -0.530759331 kegg kegg NA NA no no no no no no Human papillomavirus infection Rap1 signaling pathway 0.412173913 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Relaxin signaling pathway 0 0.450592885 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Renin secretion 0 -0.513833992 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Renin-angiotensin system 0 0.619565217 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Retinol metabolism 0 -0.522727273 -0.543886744 kegg kegg NA NA no no no no no no Human papillomavirus infection Retrograde endocannabinoid signaling -0.413913043 -0.440711462 0 kegg kegg NA NA no no no no no up Human papillomavirus infection Ribosome -0.477391304 -0.456521739 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Ribosome biogenesis in eukaryotes -0.554782609 -0.530632411 0 kegg kegg NA NA no no no no no no Human papillomavirus infection RIG-I-like receptor signaling pathway 0 0.509881423 0 kegg kegg NA NA no no no no no no Human papillomavirus infection RNA degradation -0.63826087 -0.454545455 0 kegg kegg NA NA no no no no no no Human papillomavirus infection RNA polymerase -0.554782609 -0.596837945 -0.427541828 kegg kegg NA NA no no no no no no Human papillomavirus infection RNA transport 0 -0.429841897 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Salmonella infection 0.42 0.496047431 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Sarcina 0 0.444554224 0 kegg Genus NA 0.0703 no no no no no no Human papillomavirus infection Selenocompound metabolism -0.544347826 0 -0.514800515 kegg kegg NA NA no no no no no no Human papillomavirus infection Sphingolipid signaling pathway 0 0.695652174 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Staphylococcus aureus infection 0 0.557312253 0 kegg kegg NA NA no no no up no no Human papillomavirus infection Steroid biosynthesis -0.697391304 -0.583992095 -0.488803089 kegg kegg NA NA no no no no no no Human papillomavirus infection Steroid hormone biosynthesis 0 -0.644268775 -0.413642214 kegg kegg NA NA no no no no no no Human papillomavirus infection Synthesis and degradation of ketone bodies 0 -0.693675889 -0.463063063 kegg kegg NA NA no no no no no no Human papillomavirus infection Taste transduction -0.487826087 -0.625494071 0 kegg kegg NA NA no no no no no up Human papillomavirus infection Taurine and hypotaurine metabolism -0.439130435 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Terpenoid backbone biosynthesis -0.726956522 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection TGF-beta signaling pathway -0.566956522 -0.43972332 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Th1 and Th2 cell differentiation 0 0.526679842 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Th17 cell differentiation 0 0.528656126 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Thermogenesis -0.526086957 -0.466403162 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Thiamine metabolism 0 -0.795454545 0 kegg kegg NA NA no no no no no no Human papillomavirus infection TNF signaling pathway 0 0.62944664 0.576576577 kegg kegg NA NA no no no no no no Human papillomavirus infection Toll-like receptor signaling pathway 0 0.650197628 0.662033462 yes kegg kegg NA NA no no no no no no Human papillomavirus infection Toxoplasmosis 0 0.42687747 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Tryptophan metabolism 0 0 -0.42007722 kegg kegg NA NA no no no no up no Human papillomavirus infection Tuberculosis 0 0.565217391 0 kegg kegg NA NA no no no no no dn Human papillomavirus infection Type I diabetes mellitus 0.839130435 0.907114625 0.843500644 kegg kegg NA NA no no no no no no Human papillomavirus infection Tyrosine metabolism 0 -0.696640316 -0.514543115 kegg kegg NA NA no no no no no no Human papillomavirus infection Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.587944664 -0.52020592 kegg kegg NA NA no no no no no no Human papillomavirus infection Ubiquitin mediated proteolysis 0 -0.530632411 0 kegg kegg NA NA no no no no no no Human papillomavirus infection "Valine, leucine and isoleucine degradation" 0 -0.583003953 -0.526126126 kegg kegg NA NA no no no no no no Human papillomavirus infection Vascular smooth muscle contraction 0 -0.421936759 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Vasopressin-regulated water reabsorption 0 -0.451581028 0 kegg kegg NA NA no no no no no no Human papillomavirus infection VEGF signaling pathway 0 0.536561265 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Viral protein interaction with cytokine and cytokine receptor 0.425217391 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Vitamin digestion and absorption -0.606086957 0 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Wnt signaling pathway -0.456521739 -0.436758893 0 kegg kegg NA NA no no no no no no Human papillomavirus infection Yersinia infection 0.464347826 0.639328063 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection ABC transporters 0 -0.494071146 0 kegg kegg NA NA no no no no up up Human T-cell leukemia virus 1 infection Alcoholism 0.426086957 0 0.415186615 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Amino sugar and nucleotide sugar metabolism 0 -0.476284585 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Amphetamine addiction -0.411304348 0 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Anaerostipes 0.41184124 0 0 butyrate-producing kegg Genus NA 0.568 no no no no no no Human T-cell leukemia virus 1 infection Antifolate resistance -0.528695652 -0.65513834 -0.471814672 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Antigen processing and presentation 0.985217391 0.979249012 0.95984556 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Apoptosis - multiple species 0 -0.51284585 -0.421621622 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Axon guidance 0 0.502964427 0 kegg kegg NA NA no no no no up up Human T-cell leukemia virus 1 infection Base excision repair 0 -0.4743083 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Carbohydrate digestion and absorption 0 0 -0.407722008 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Cell adhesion molecules 0.506086957 0.504940711 0.713513514 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Cell cycle 0 -0.415019763 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Cellular senescence 0.634782609 0.431818182 0.613642214 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Cholesterol metabolism 0.477391304 0.543478261 0 yes kegg kegg NA NA no no no no no up Human T-cell leukemia virus 1 infection Cocaine addiction 0 -0.425889328 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Complement and coagulation cascades 0 0 0.406949807 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Cortisol synthesis and secretion -0.475652174 -0.527667984 0 kegg kegg NA NA no no no no no up Human T-cell leukemia virus 1 infection Cushing syndrome -0.520869565 -0.496047431 0 kegg kegg NA NA no no no no no up Human T-cell leukemia virus 1 infection Desulfovibrio 0 0.444554224 0 kegg Genus NA 0.27 no no no no no no Human T-cell leukemia virus 1 infection Drug metabolism - cytochrome P450 0.452173913 0 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Endocrine resistance -0.623478261 -0.656126482 -0.409266409 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Endocytosis 0.60173913 0.508893281 0.633462033 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Epithelial cell signaling in Helicobacter pylori infection 0 0 0.43011583 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Ether lipid metabolism -0.466956522 0 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Fanconi anemia pathway 0 -0.570158103 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Fructose and mannose metabolism 0 -0.60770751 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Glycerolipid metabolism 0 -0.604743083 0 kegg kegg NA NA no no no no no up Human T-cell leukemia virus 1 infection Glycerophospholipid metabolism -0.728695652 -0.660079051 -0.446074646 kegg kegg NA NA no no no no no up Human T-cell leukemia virus 1 infection "Glycine, serine and threonine metabolism" 0 -0.422924901 0 kegg kegg NA NA no no no no up no Human T-cell leukemia virus 1 infection Glycosphingolipid biosynthesis - ganglio series 0 0 -0.434491634 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.554347826 -0.428056628 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection GnRH secretion 0 0 -0.414414414 kegg kegg NA NA no no no no up up Human T-cell leukemia virus 1 infection "Growth hormone synthesis, secretion and action" -0.479130435 -0.554347826 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Hedgehog signaling pathway -0.583478261 -0.585968379 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Homologous recombination 0 -0.51284585 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Human cytomegalovirus infection 0.956521739 0.972332016 0.920978121 kegg kegg NA NA no no no no no dn Human T-cell leukemia virus 1 infection Human papillomavirus infection 0.56 0 0.527413127 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Inositol phosphate metabolism -0.502608696 -0.56027668 -0.566280566 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Insulin secretion -0.515652174 0 0 yes kegg kegg NA NA no no no no up up Human T-cell leukemia virus 1 infection JAK-STAT signaling pathway 0 0 -0.400514801 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Leishmaniasis 0.429565217 0.427865613 0.409009009 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Leukocyte transendothelial migration 0 0.502964427 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Lysine degradation 0 -0.580039526 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Lysosome 0 0.486166008 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Mannose type O-glycan biosynthesis 0 -0.434782609 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection MAPK signaling pathway 0 -0.481225296 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Maturity onset diabetes of the young -0.415652174 -0.423913043 0 kegg kegg NA NA no no no no up no Human T-cell leukemia virus 1 infection Metabolism of xenobiotics by cytochrome P450 0.427826087 0 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Natural killer cell mediated cytotoxicity 0.674782609 0.504940711 0.675418275 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Neuroactive ligand-receptor interaction 0 0.484189723 0 kegg kegg NA NA no no no up up up Human T-cell leukemia virus 1 infection Neutrophil extracellular trap formation 0 0 0.419047619 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Nicotine addiction 0 -0.631422925 0 kegg kegg NA NA no no no no up up Human T-cell leukemia virus 1 infection Notch signaling pathway 0 -0.54743083 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection One carbon pool by folate 0 -0.447628458 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Oscillospira -0.417391304 0 0 LPS-producing kegg Genus NA 0.62 no no no no no no Human T-cell leukemia virus 1 infection Other types of O-glycan biosynthesis 0 -0.621541502 -0.44993565 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Ovarian steroidogenesis -0.489565217 0 0 kegg kegg NA NA no no no no up up Human T-cell leukemia virus 1 infection p53 signaling pathway 0 -0.467391304 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Pathogenic Escherichia coli infection 0.42173913 0.435770751 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Pertussis 0.413913043 0 0.403603604 kegg kegg NA NA no no no no no dn Human T-cell leukemia virus 1 infection Phagosome 0.471304348 0.488142292 0.596911197 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Phosphatidylinositol signaling system 0 0 -0.409266409 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Phototransduction 0 0.501976285 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Platinum drug resistance 0 -0.564229249 -0.445045045 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection PPAR signaling pathway 0.497391304 0 0.422136422 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Progesterone-mediated oocyte maturation 0 -0.544466403 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Proteasome 0 0.418972332 0.458172458 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Purine metabolism 0 -0.444664032 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Regulation of actin cytoskeleton 0.514782609 0 0.44041184 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Renin-angiotensin system 0 0.448616601 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Salmonella infection 0.502608696 0.469367589 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Selenocompound metabolism 0 -0.632411067 -0.403603604 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Signaling pathways regulating pluripotency of stem cells 0 0 -0.442471042 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Sphingolipid signaling pathway 0 0.484189723 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Spliceosome 0 -0.431818182 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Staphylococcus aureus infection 0 0.453557312 0.435521236 kegg kegg NA NA no no no up no no Human T-cell leukemia virus 1 infection Steroid biosynthesis -0.430434783 0 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Taste transduction 0 0 -0.488288288 kegg kegg NA NA no no no no no up Human T-cell leukemia virus 1 infection Taurine and hypotaurine metabolism -0.495652174 -0.609683794 -0.457400257 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Tuberculosis 0 0.418972332 0 kegg kegg NA NA no no no no no dn Human T-cell leukemia virus 1 infection Type I diabetes mellitus 0.471304348 0.507905138 0.717631918 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Vasopressin-regulated water reabsorption -0.482608696 0 0 kegg kegg NA NA no no no no no no Human T-cell leukemia virus 1 infection Vitamin digestion and absorption -0.55826087 -0.41798419 0 kegg kegg NA NA no no no no no no Huntington disease 2-Oxocarboxylic acid metabolism -0.542608696 0 0 kegg kegg NA NA no no no no no no Huntington disease Adherens junction 0 0.662055336 0.561647362 kegg kegg NA NA no no no no no no Huntington disease Adrenergic signaling in cardiomyocytes 0.706956522 0.820158103 0 kegg kegg NA NA no no no no no up Huntington disease AGE-RAGE signaling pathway in diabetic complications 0 -0.831027668 -0.517631918 kegg kegg NA NA no no no no no no Huntington disease "Alanine, aspartate and glutamate metabolism" -0.49826087 -0.767786561 -0.48957529 kegg kegg NA NA no no no no no no Huntington disease Aldosterone synthesis and secretion 0.586086957 0.780632411 0 kegg kegg NA NA no no no no up up Huntington disease Aldosterone-regulated sodium reabsorption 0 0 -0.441184041 kegg kegg NA NA no no no no no no Huntington disease alpha-Linolenic acid metabolism -0.646956522 -0.75 0 kegg kegg NA NA no no no no no no Huntington disease Alzheimer disease 0.982608696 0.994071146 0.942084942 kegg kegg NA NA no no no no no no Huntington disease Amino sugar and nucleotide sugar metabolism -0.64 0 0 kegg kegg NA NA no no no no no no Huntington disease Aminoacyl-tRNA biosynthesis -0.596521739 0 0 kegg kegg NA NA no no no no no no Huntington disease AMPK signaling pathway 0 0.461462451 0 kegg kegg NA NA no no no no no no Huntington disease Amyotrophic lateral sclerosis 0.976521739 0.981225296 0.968597169 kegg kegg NA NA no no no no no no Huntington disease Apelin signaling pathway 0 0.742094862 0 kegg kegg NA NA no no no no no no Huntington disease Apoptosis -0.492173913 -0.58201581 0 kegg kegg NA NA no no no no no no Huntington disease Apoptosis - multiple species 0 -0.429841897 0 kegg kegg NA NA no no no no no no Huntington disease Arginine and proline metabolism 0 -0.791501976 -0.588159588 kegg kegg NA NA no no no no up no Huntington disease Arginine biosynthesis -0.529565217 -0.716403162 -0.436808237 kegg kegg NA NA no no no no no no Huntington disease Autophagy - animal 0 -0.71541502 -0.513513514 kegg kegg NA NA no no no no no no Huntington disease Axon guidance 0.504347826 0 0 kegg kegg NA NA no no no no up up Huntington disease B cell receptor signaling pathway 0 -0.627470356 0 kegg kegg NA NA no no no no no no Huntington disease beta-Alanine metabolism -0.731304348 0 0 kegg kegg NA NA no no no no no no Huntington disease Bile secretion 0.414782609 0.51284585 0 kegg kegg NA NA no no no no no no Huntington disease Biosynthesis of amino acids -0.826086957 -0.661067194 0 kegg kegg NA NA no no no no no no Huntington disease Biosynthesis of unsaturated fatty acids -0.430434783 0 0 kegg kegg NA NA no no no no no no Huntington disease Butanoate metabolism -0.58 0 0 kegg kegg NA NA no no no no no no Huntington disease C-type lectin receptor signaling pathway 0 -0.631422925 -0.435521236 kegg kegg NA NA no no no no no no Huntington disease Calcium signaling pathway 0.71826087 0.744071146 0 kegg kegg NA NA no no no no up up Huntington disease cAMP signaling pathway 0.755652174 0 0 yes kegg kegg NA NA no no no no up up Huntington disease Carbohydrate digestion and absorption 0 -0.489130435 0 kegg kegg NA NA no no no no no no Huntington disease Carbon metabolism -0.777391304 0 0 kegg kegg NA NA no no no no no no Huntington disease Cardiac muscle contraction 0.960869565 0.967391304 0.928957529 kegg kegg NA NA no no no no no up Huntington disease Cell adhesion molecules -0.58 -0.450592885 0 kegg kegg NA NA no no no no no no Huntington disease Cellular senescence 0 -0.438735178 0 kegg kegg NA NA no no no no no no Huntington disease cGMP-PKG signaling pathway 0 -0.662055336 0 kegg kegg NA NA no no no no no no Huntington disease Chemokine signaling pathway 0 -0.466403162 0 kegg kegg NA NA no no no no no no Huntington disease Cholinergic synapse 0 -0.440711462 0 kegg kegg NA NA no no no no no no Huntington disease Circadian entrainment 0 0.589920949 0 kegg kegg NA NA no no no no up up Huntington disease Circadian rhythm 0.669565217 0 0 kegg kegg NA NA no no no no no no Huntington disease Citrate cycle (TCA cycle) 0 0.41798419 0 kegg kegg NA NA no no no no no no Huntington disease Complement and coagulation cascades -0.606956522 -0.651185771 0 kegg kegg NA NA no no no no no no Huntington disease Cortisol synthesis and secretion 0 0.43083004 0 kegg kegg NA NA no no no no no up Huntington disease Cushing syndrome 0.445217391 0.48715415 0 kegg kegg NA NA no no no no no up Huntington disease Cysteine and methionine metabolism 0 0.455533597 0 kegg kegg NA NA no no no no no no Huntington disease Cytokine-cytokine receptor interaction 0 -0.449604743 0 kegg kegg NA NA no no no no no no Huntington disease DNA replication 0 0.443675889 0 kegg kegg NA NA no no no no no no Huntington disease Dopaminergic synapse 0.640869565 0.723320158 0 kegg kegg NA NA no no no no up no Huntington disease Drug metabolism - cytochrome P450 0 0.505928854 0 kegg kegg NA NA no no no no no no Huntington disease Drug metabolism - other enzymes -0.603478261 0.566205534 0 kegg kegg NA NA no no no no no no Huntington disease EGFR tyrosine kinase inhibitor resistance 0 0.661067194 0 kegg kegg NA NA no no no no no no Huntington disease Endocrine and other factor-regulated calcium reabsorption 0.50173913 0.811264822 0 kegg kegg NA NA no no no no no no Huntington disease Endocrine resistance 0.419130435 0 0 kegg kegg NA NA no no no no no no Huntington disease Endocytosis -0.512173913 -0.48715415 0 kegg kegg NA NA no no no no no no Huntington disease ErbB signaling pathway 0 -0.450592885 0 kegg kegg NA NA no no no no no no Huntington disease Ether lipid metabolism 0.72 0.471343874 0 kegg kegg NA NA no no no no no no Huntington disease Fat digestion and absorption -0.536521739 -0.632411067 0 yes kegg kegg NA NA no no no no up up Huntington disease Fatty acid biosynthesis -0.42173913 -0.812252964 -0.604890605 kegg kegg NA NA no no no no no no Huntington disease Fatty acid degradation -0.647826087 -0.853754941 0 kegg kegg NA NA no no no no no no Huntington disease Fatty acid elongation -0.533913043 0 0 kegg kegg NA NA no no no no no no Huntington disease Fatty acid metabolism -0.750434783 -0.830039526 0 kegg kegg NA NA no no no no no no Huntington disease Fc epsilon RI signaling pathway 0 -0.718379447 0 kegg kegg NA NA no no no no no no Huntington disease Fc gamma R-mediated phagocytosis -0.503478261 -0.677865613 -0.403346203 kegg kegg NA NA no no no no no no Huntington disease Focal adhesion 0 0.520750988 0.440926641 kegg kegg NA NA no no no no up up Huntington disease Folate biosynthesis 0 0.431818182 0 kegg kegg NA NA no no no no no no Huntington disease FoxO signaling pathway 0 -0.759881423 0 kegg kegg NA NA no no no no no no Huntington disease Fructose and mannose metabolism -0.755652174 -0.567193676 -0.483912484 kegg kegg NA NA no no no no no no Huntington disease GABAergic synapse 0 -0.640316206 0 kegg kegg NA NA no no no no up up Huntington disease Galactose metabolism -0.752173913 -0.781620553 0 kegg kegg NA NA no no no no no no Huntington disease Gastric acid secretion 0 0.730237154 0.538481338 kegg kegg NA NA no no no no no no Huntington disease Glucagon signaling pathway 0 0.778656126 0 kegg kegg NA NA no no no no no no Huntington disease Glutathione metabolism 0 0.706521739 0 kegg kegg NA NA no no no no no no Huntington disease Glycerolipid metabolism 0 -0.608695652 0 kegg kegg NA NA no no no no no up Huntington disease Glycolysis / Gluconeogenesis -0.667826087 0.425889328 0 kegg kegg NA NA no no no no no no Huntington disease Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.734189723 0 kegg kegg NA NA no no no no no no Huntington disease Glycosaminoglycan biosynthesis - keratan sulfate 0.557391304 0 0 kegg kegg NA NA no no no no no no Huntington disease Glycosaminoglycan degradation 0 -0.416007905 0 kegg kegg NA NA no no no no no up Huntington disease Glyoxylate and dicarboxylate metabolism -0.636521739 -0.727272727 -0.501930502 kegg kegg NA NA no no no no no no Huntington disease GnRH secretion 0 -0.419960474 0 kegg kegg NA NA no no no no up up Huntington disease GnRH signaling pathway 0 0.503952569 0 kegg kegg NA NA no no no no no no Huntington disease Hedgehog signaling pathway 0.526086957 0 0 kegg kegg NA NA no no no no no no Huntington disease HIF-1 signaling pathway 0 0.627470356 0 kegg kegg NA NA no no no no no no Huntington disease Hippo signaling pathway 0 0.638339921 0.566280566 kegg kegg NA NA no no no no no no Huntington disease Hippo signaling pathway - multiple species 0 -0.746047431 0 kegg kegg NA NA no no no no no no Huntington disease IL-17 signaling pathway 0 -0.558300395 -0.465122265 kegg kegg NA NA no no no no no no Huntington disease Inflammatory mediator regulation of TRP channels 0.519130435 0.814229249 0 kegg kegg NA NA no no no no no no Huntington disease Inositol phosphate metabolism 0 -0.459486166 0 kegg kegg NA NA no no no no no no Huntington disease Insulin resistance 0.417391304 -0.541501976 0 kegg kegg NA NA no no no no no no Huntington disease Insulin secretion 0 0.54743083 0 yes kegg kegg NA NA no no no no up up Huntington disease Insulin signaling pathway 0 0.675889328 0 kegg kegg NA NA no no no no no no Huntington disease JAK-STAT signaling pathway 0 -0.741106719 0 kegg kegg NA NA no no no no no no Huntington disease Long-term depression 0.552173913 0 0 kegg kegg NA NA no no no no no no Huntington disease Mannose type O-glycan biosynthesis 0.510434783 0 0 kegg kegg NA NA no no no no no no Huntington disease MAPK signaling pathway 0 -0.690711462 0 kegg kegg NA NA no no no no no no Huntington disease Melanogenesis 0.487826087 0.845849802 0 kegg kegg NA NA no no no no no no Huntington disease Metabolism of xenobiotics by cytochrome P450 0 0.455533597 0 kegg kegg NA NA no no no no no no Huntington disease Mineral absorption 0.410434783 0.624505929 0 kegg kegg NA NA no no no no no no Huntington disease Mitophagy - animal 0.535652174 0.827075099 0 kegg kegg NA NA no no no no no no Huntington disease mRNA surveillance pathway 0.760869565 0.657114625 0 kegg kegg NA NA no no no no no no Huntington disease mTOR signaling pathway 0 0.653162055 0 kegg kegg NA NA no no no no no no Huntington disease Mucin type O-glycan biosynthesis 0 -0.441699605 0 kegg kegg NA NA no no no no no no Huntington disease N-Glycan biosynthesis 0 0.568181818 0 kegg kegg NA NA no no no no no no Huntington disease Natural killer cell mediated cytotoxicity -0.512173913 -0.429841897 0 kegg kegg NA NA no no no no no no Huntington disease Neuroactive ligand-receptor interaction 0 -0.533596838 0 kegg kegg NA NA no no no up up up Huntington disease Neurotrophin signaling pathway 0.54 0 0 kegg kegg NA NA no no no no no no Huntington disease Neutrophil extracellular trap formation -0.525217391 -0.550395257 0 kegg kegg NA NA no no no no no no Huntington disease NF-kappa B signaling pathway 0 -0.717391304 -0.496267696 kegg kegg NA NA no no no no no no Huntington disease Nicotinate and nicotinamide metabolism -0.446956522 -0.756916996 -0.488030888 kegg kegg NA NA no no no no no no Huntington disease Nitrogen metabolism -0.468695652 -0.619565217 -0.4002574 kegg kegg NA NA no no no no no no Huntington disease NOD-like receptor signaling pathway 0 -0.778656126 -0.465894466 kegg kegg NA NA no no no no no no Huntington disease Non-alcoholic fatty liver disease 0.972173913 0.96541502 0.885456885 kegg kegg NA NA no no no no no no Huntington disease Non-homologous end-joining -0.648695652 0 0 kegg kegg NA NA no no no no no no Huntington disease Olfactory transduction 0 -0.615612648 0 kegg kegg NA NA no no no no no no Huntington disease Oocyte meiosis 0.44 0.43083004 0 kegg kegg NA NA no no no no no no Huntington disease Oscillospira 0 -0.477272727 0 LPS-producing kegg Genus NA 0.62 no no no no no no Huntington disease Osteoclast differentiation 0 -0.749011858 -0.46048906 kegg kegg NA NA no no no no no no Huntington disease Other glycan degradation 0 -0.495059289 0 kegg kegg NA NA no no no no no no Huntington disease Oxidative phosphorylation 0.977391304 0.990118577 0.958558559 kegg kegg NA NA no no no no no no Huntington disease Pancreatic secretion 0.648695652 0.73715415 0 kegg kegg NA NA no no no no no no Huntington disease Pantothenate and CoA biosynthesis 0 -0.799407115 -0.447876448 kegg kegg NA NA no no no no no dn Huntington disease "Parathyroid hormone synthesis, secretion and action" 0.669565217 0.799407115 0 kegg kegg NA NA no no no no no no Huntington disease Parkinson disease 0.84 0.967391304 0.503217503 kegg kegg NA NA no no no no no no Huntington disease Pentose and glucuronate interconversions 0 0.535573123 0 kegg kegg NA NA no no no no no no Huntington disease Pentose phosphate pathway -0.544347826 -0.580039526 -0.417503218 kegg kegg NA NA no no no no no no Huntington disease Peroxisome -0.580869565 -0.73715415 0 kegg kegg NA NA no no no no no no Huntington disease Phagosome -0.616521739 -0.463438735 0 kegg kegg NA NA no no no no no no Huntington disease Phosphatidylinositol signaling system 0.576521739 0 0 kegg kegg NA NA no no no no no no Huntington disease Phospholipase D signaling pathway 0 -0.523715415 0 kegg kegg NA NA no no no no up up Huntington disease Phototransduction 0 0.506916996 0.455855856 kegg kegg NA NA no no no no no no Huntington disease Platelet activation 0 0.543478261 0 kegg kegg NA NA no no no no no no Huntington disease Porphyrin and chlorophyll metabolism 0 0.416996047 0 kegg kegg NA NA no no no no no no Huntington disease PPAR signaling pathway 0 -0.616600791 0 kegg kegg NA NA no no no no no no Huntington disease Prolactin signaling pathway 0 -0.649209486 -0.535135135 kegg kegg NA NA no no no no no no Huntington disease Propanoate metabolism 0 0.42687747 0 kegg kegg NA NA no no no no no no Huntington disease Proteasome 0 0.482213439 0 kegg kegg NA NA no no no no no no Huntington disease Protein digestion and absorption -0.650434783 -0.852766798 -0.505791506 yes kegg kegg NA NA no no no no up up Huntington disease Protein export 0.574782609 0.765810277 0 kegg kegg NA NA no no no no no no Huntington disease Protein processing in endoplasmic reticulum 0 0.64229249 0 kegg kegg NA NA no no no no no no Huntington disease Proximal tubule bicarbonate reclamation 0 0.482213439 0 kegg kegg NA NA no no no no no no Huntington disease Purine metabolism 0 0.448616601 0 kegg kegg NA NA no no no no no no Huntington disease Pyrimidine metabolism -0.720869565 0 0 kegg kegg NA NA no no no no no no Huntington disease Pyruvate metabolism 0 0.562252964 0 kegg kegg NA NA no no no no no no Huntington disease Rap1 signaling pathway 0 0.433794466 0 kegg kegg NA NA no no no no no no Huntington disease Ras signaling pathway 0 0.500988142 0 yes kegg kegg NA NA no no no no up up Huntington disease Regulation of actin cytoskeleton 0 0 0.437580438 kegg kegg NA NA no no no no no no Huntington disease Relaxin signaling pathway 0.551304348 0 0 kegg kegg NA NA no no no no no no Huntington disease Renin secretion 0 0.825098814 0 kegg kegg NA NA no no no no no no Huntington disease Renin-angiotensin system 0 -0.615612648 0 kegg kegg NA NA no no no no no no Huntington disease Retinol metabolism -0.524347826 0 0 kegg kegg NA NA no no no no no no Huntington disease Retrograde endocannabinoid signaling 0.812173913 0.921936759 0.753153153 kegg kegg NA NA no no no no no up Huntington disease Ribosome 0.726086957 0.87055336 0 kegg kegg NA NA no no no no no no Huntington disease RIG-I-like receptor signaling pathway 0 -0.678853755 -0.472844273 kegg kegg NA NA no no no no no no Huntington disease RNA degradation 0.713913043 0.669960474 0 kegg kegg NA NA no no no no no no Huntington disease RNA polymerase 0 0.558300395 0 kegg kegg NA NA no no no no no no Huntington disease RNA transport 0 0.543478261 0 kegg kegg NA NA no no no no no no Huntington disease Ruminococcus 0 0.417039417 0 kegg Genus NA 0.0679 no no no no no dn Huntington disease Signaling pathways regulating pluripotency of stem cells 0.595652174 0 0 kegg kegg NA NA no no no no no no Huntington disease SNARE interactions in vesicular transport 0 -0.66798419 0 kegg kegg NA NA no no no no no no Huntington disease Starch and sucrose metabolism -0.507826087 -0.822134387 0 kegg kegg NA NA no no no no no no Huntington disease Steroid biosynthesis 0 0 0.414414414 kegg kegg NA NA no no no no no no Huntington disease Sulfur metabolism -0.460869565 0 0 kegg kegg NA NA no no no no no no Huntington disease Synaptic vesicle cycle 0 -0.574110672 0 kegg kegg NA NA no no no no up up Huntington disease T cell receptor signaling pathway 0 -0.508893281 0 kegg kegg NA NA no no no no no no Huntington disease TGF-beta signaling pathway 0.727826087 0.660079051 0 kegg kegg NA NA no no no no no no Huntington disease Th17 cell differentiation 0 -0.421936759 0 kegg kegg NA NA no no no no no no Huntington disease Thermogenesis 0.954782609 0.982213439 0.928442728 kegg kegg NA NA no no no no no no Huntington disease Thiamine metabolism 0 0.419960474 0 kegg kegg NA NA no no no no no no Huntington disease Thyroid hormone signaling pathway 0 0.643280632 0.494208494 kegg kegg NA NA no no no no no no Huntington disease Thyroid hormone synthesis 0 0.636363636 0 kegg kegg NA NA no no no no no no Huntington disease Tight junction 0 0.527667984 0 kegg kegg NA NA no no no no no no Huntington disease TNF signaling pathway 0 -0.552371542 0 kegg kegg NA NA no no no no no no Huntington disease Toll-like receptor signaling pathway 0 -0.657114625 0 yes kegg kegg NA NA no no no no no no Huntington disease Tryptophan metabolism -0.547826087 0 0 kegg kegg NA NA no no no no up no Huntington disease Type I diabetes mellitus -0.474782609 0 0 kegg kegg NA NA no no no no no no Huntington disease Type II diabetes mellitus 0 -0.624505929 -0.497554698 kegg kegg NA NA no no no no no no Huntington disease Ubiquitin mediated proteolysis 0.548695652 0.846837945 0 kegg kegg NA NA no no no no no no Huntington disease "Valine, leucine and isoleucine degradation" -0.454782609 0 0 kegg kegg NA NA no no no no no no Huntington disease Vascular smooth muscle contraction 0.686086957 0.860671937 0 kegg kegg NA NA no no no no no no Huntington disease Vasopressin-regulated water reabsorption 0.53826087 0.778656126 0.414414414 kegg kegg NA NA no no no no no no Huntington disease VEGF signaling pathway 0 -0.444664032 0 kegg kegg NA NA no no no no no no Huntington disease Vitamin digestion and absorption 0.656521739 0 0 kegg kegg NA NA no no no no no no Huntington disease Wnt signaling pathway 0.720869565 0.647233202 0 kegg kegg NA NA no no no no no no Hypertrophic cardiomyopathy 2-Oxocarboxylic acid metabolism 0.453913043 0.504940711 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy ABC transporters 0 -0.496047431 0 kegg kegg NA NA no up up no up up Hypertrophic cardiomyopathy Adherens junction 0.89826087 0.947628458 0.957014157 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Adipocytokine signaling pathway 0 -0.618577075 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy AGE-RAGE signaling pathway in diabetic complications 0 -0.54743083 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy "Alanine, aspartate and glutamate metabolism" 0 -0.649209486 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Allograft rejection 0.468695652 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy alpha-Linolenic acid metabolism 0.42 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Alzheimer disease 0 0.545454545 0.400772201 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Amyotrophic lateral sclerosis 0 0.565217391 0.56010296 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Apelin signaling pathway -0.506956522 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Apoptosis 0.584347826 0 0.451737452 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Apoptosis - multiple species -0.583478261 -0.555335968 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Arginine and proline metabolism 0 -0.564229249 0 kegg kegg NA NA no up up no up no Hypertrophic cardiomyopathy Arginine biosynthesis 0 -0.583003953 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Ascorbate and aldarate metabolism 0 0.436758893 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Asthma 0 0.511857708 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Autoimmune thyroid disease 0.468695652 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Autophagy - animal -0.729565217 -0.860671937 -0.525868726 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Autophagy - other -0.894782609 -0.793478261 -0.526126126 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy B cell receptor signaling pathway 0 -0.51284585 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Bacterial invasion of epithelial cells 0.917391304 0.896245059 0.930501931 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Basal transcription factors -0.746956522 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Base excision repair -0.531304348 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy beta-Alanine metabolism 0.507826087 0.443675889 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Bifidobacterium 0 0.445271301 0 acetate-producing kegg Genus NA 0.105 no up up no dn no Hypertrophic cardiomyopathy Bile secretion 0 0.418972332 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Biosynthesis of amino acids 0.455652174 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Biosynthesis of cofactors 0.430434783 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Bladder cancer 0 -0.540513834 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Breast cancer -0.450434783 -0.681818182 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Butanoate metabolism 0 0.498023715 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy C-type lectin receptor signaling pathway -0.540869565 -0.617588933 -0.548519949 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Calcium signaling pathway 0 0.414031621 0 kegg kegg NA NA no up up no up up Hypertrophic cardiomyopathy Carbohydrate digestion and absorption -0.506086957 -0.429841897 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Carbon metabolism 0.511304348 0.450592885 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Cardiac muscle contraction 0 0.574110672 0.505791506 kegg kegg NA NA no up up no no up Hypertrophic cardiomyopathy Cell adhesion molecules 0.516521739 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Cell cycle -0.432173913 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Chagas disease 0 -0.567193676 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Choline metabolism in cancer -0.535652174 -0.53458498 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Cholinergic synapse -0.467826087 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Chronic myeloid leukemia -0.42173913 -0.545454545 -0.531274131 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Circadian entrainment 0 0.658102767 0 kegg kegg NA NA no up up no up up Hypertrophic cardiomyopathy Circadian rhythm -0.705217391 0 -0.415186615 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Citrate cycle (TCA cycle) 0 0.495059289 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Complement and coagulation cascades 0 0 0.420592021 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Coronavirus disease - COVID-19 -0.430434783 0.416996047 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Cytokine-cytokine receptor interaction 0 0 0.703989704 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Cytosolic DNA-sensing pathway 0 -0.45256917 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Dopaminergic synapse 0 0.510869565 0 kegg kegg NA NA no up up no up no Hypertrophic cardiomyopathy Drug metabolism - cytochrome P450 0 0.637351779 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Drug metabolism - other enzymes 0 0.727272727 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy EGFR tyrosine kinase inhibitor resistance -0.483478261 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Endocrine and other factor-regulated calcium reabsorption 0 0.467391304 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Endometrial cancer 0 -0.599802372 -0.412355212 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy ErbB signaling pathway -0.448695652 -0.511857708 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Estrogen signaling pathway 0 0.453557312 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Fatty acid biosynthesis 0 -0.556324111 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Fatty acid degradation 0 -0.526679842 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Fatty acid metabolism 0 -0.466403162 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Fc epsilon RI signaling pathway 0 -0.467391304 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Focal adhesion 0.89826087 0.955533597 0.913256113 kegg kegg NA NA no up up no up up Hypertrophic cardiomyopathy FoxO signaling pathway 0 -0.679841897 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Fructose and mannose metabolism 0.439130435 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy GABAergic synapse 0 -0.467391304 0 kegg kegg NA NA no up up no up up Hypertrophic cardiomyopathy Galactose metabolism 0.510434783 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Gap junction 0.419130435 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Gastric acid secretion 0.844347826 0.932806324 0.898584299 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Glioma -0.543478261 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Glutathione metabolism 0 0.434782609 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Glycerolipid metabolism 0 -0.514822134 0 kegg kegg NA NA no up up no no up Hypertrophic cardiomyopathy Glycerophospholipid metabolism -0.489565217 -0.56916996 0 kegg kegg NA NA no up up no no up Hypertrophic cardiomyopathy Glycolysis / Gluconeogenesis 0.413043478 0.579051383 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.606719368 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.593043478 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Glyoxylate and dicarboxylate metabolism 0 -0.59486166 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy GnRH secretion -0.450434783 -0.514822134 0 kegg kegg NA NA no up up no up up Hypertrophic cardiomyopathy Graft-versus-host disease 0.468695652 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Hematopoietic cell lineage 0 0.436758893 0.514285714 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Hepatitis B -0.588695652 -0.808300395 -0.498326898 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Hepatitis C 0 -0.570158103 -0.428571429 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Hepatocellular carcinoma 0.850434783 0.927865613 0.896010296 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy HIF-1 signaling pathway -0.54 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Hippo signaling pathway 0.837391304 0.907114625 0.927413127 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Hippo signaling pathway - multiple species 0 -0.510869565 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Homologous recombination 0 -0.41798419 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Human papillomavirus infection 0.419130435 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Huntington disease 0 0.550395257 0.484427284 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Inflammatory mediator regulation of TRP channels 0 0.501976285 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Influenza A 0.574782609 0 0.686486486 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Inositol phosphate metabolism 0 -0.5 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Insulin resistance -0.71826087 -0.679841897 -0.643758044 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Insulin signaling pathway -0.569565217 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy JAK-STAT signaling pathway 0 -0.681818182 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Lachnospira 0 0.573264164 0 butyrate-producing kegg Genus NA 0.279 no up up no no no Hypertrophic cardiomyopathy Leukocyte transendothelial migration 0.751304348 0.650197628 0.739253539 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Linoleic acid metabolism 0 0.419960474 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Long-term potentiation -0.569565217 0 0 kegg kegg NA NA no up up no no up Hypertrophic cardiomyopathy Longevity regulating pathway 0 -0.505928854 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Lysine degradation -0.452173913 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Malaria 0 -0.435770751 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy MAPK signaling pathway 0 -0.537549407 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Maturity onset diabetes of the young -0.405217391 0 0 kegg kegg NA NA no up up no up no Hypertrophic cardiomyopathy Melanogenesis 0 0.484189723 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Melanoma -0.573043478 -0.675889328 -0.438095238 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Metabolism of xenobiotics by cytochrome P450 0 0.669960474 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy MicroRNAs in cancer 0 -0.740118577 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Morphine addiction 0 0.481225296 0 kegg kegg NA NA no up up no up up Hypertrophic cardiomyopathy mRNA surveillance pathway -0.605217391 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy mTOR signaling pathway -0.46173913 0 -0.413899614 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Mucin type O-glycan biosynthesis 0 -0.575098814 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy N-Glycan biosynthesis 0 0.477272727 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Natural killer cell mediated cytotoxicity 0.451304348 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Neurotrophin signaling pathway -0.426956522 -0.540513834 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Neutrophil extracellular trap formation 0.448695652 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy NF-kappa B signaling pathway 0 -0.730237154 -0.643758044 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Nicotinate and nicotinamide metabolism 0 -0.505928854 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Nitrogen metabolism 0 -0.595849802 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy NOD-like receptor signaling pathway 0 -0.699604743 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Non-alcoholic fatty liver disease 0 0.453557312 0.459202059 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Non-small cell lung cancer -0.433043478 -0.490118577 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Oocyte meiosis -0.480869565 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Osteoclast differentiation 0 -0.484189723 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Other glycan degradation 0 -0.423913043 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Other types of O-glycan biosynthesis -0.560869565 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Ovarian steroidogenesis 0.406086957 0 0 kegg kegg NA NA no up up no up up Hypertrophic cardiomyopathy Oxidative phosphorylation 0 0.565217391 0.504761905 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Oxytocin signaling pathway 0.888695652 0.761857708 0.665122265 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy p53 signaling pathway -0.744347826 -0.622529644 -0.448133848 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Pancreatic secretion 0 0.56916996 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Pantothenate and CoA biosynthesis 0 -0.486166008 0 kegg kegg NA NA no up up no no dn Hypertrophic cardiomyopathy Parkinson disease 0 0.45256917 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Pathogenic Escherichia coli infection 0.53826087 0 0.631145431 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Pathways in cancer -0.565217391 -0.536561265 -0.424967825 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Pathways of neurodegeneration - multiple diseases 0 0.416007905 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy PD-L1 expression and PD-1 checkpoint pathway in cancer -0.544347826 -0.779644269 -0.551866152 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Pentose and glucuronate interconversions 0 0.482213439 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Pentose phosphate pathway 0.48173913 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Peroxisome 0 -0.554347826 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Phagosome 0.586086957 0 0.418790219 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Phenylalanine metabolism 0.705217391 0.712450593 0.622651223 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Phosphatidylinositol signaling system -0.554782609 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Phospholipase D signaling pathway 0 -0.433794466 0 kegg kegg NA NA no up up no up up Hypertrophic cardiomyopathy Phototransduction 0 0.545454545 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Platelet activation 0.911304348 0.941699605 0.872072072 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Platinum drug resistance -0.635652174 -0.501976285 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy PPAR signaling pathway 0 -0.567193676 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Prevotella 0 -0.414653828 0 acetate-producing kegg Genus NA 0.287 no up up no no no Hypertrophic cardiomyopathy Prion disease 0 0.578063241 0.576833977 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Progesterone-mediated oocyte maturation -0.593913043 -0.457509881 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Prolactin signaling pathway 0 -0.468379447 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Prostate cancer -0.513913043 -0.603754941 -0.543371943 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Proteasome -0.611304348 0.470355731 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Protein digestion and absorption 0 -0.503952569 0 yes kegg kegg NA NA no up up no up up Hypertrophic cardiomyopathy Protein export -0.649565217 0.457509881 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Proteoglycans in cancer 0 0.479249012 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Proximal tubule bicarbonate reclamation 0 0.490118577 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Pyrimidine metabolism 0 0.507905138 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Rap1 signaling pathway 0.832173913 0.859683794 0.827027027 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Ras signaling pathway 0 0.570158103 0 yes kegg kegg NA NA no up up no up up Hypertrophic cardiomyopathy Regulation of actin cytoskeleton 0.653043478 0.66798419 0.685199485 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Renal cell carcinoma -0.419130435 0 -0.485971686 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Renin secretion 0 0.601778656 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Retrograde endocannabinoid signaling 0 0.623517787 0 kegg kegg NA NA no up up no no up Hypertrophic cardiomyopathy Rheumatoid arthritis 0 0 0.448133848 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Ribosome -0.427826087 0.420948617 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Ribosome biogenesis in eukaryotes -0.525217391 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy RIG-I-like receptor signaling pathway -0.546086957 -0.768774704 -0.602574003 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy RNA degradation -0.593913043 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy RNA polymerase -0.671304348 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Salivary secretion 0 0.59486166 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Salmonella infection 0 0 0.65971686 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Selenocompound metabolism -0.644347826 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Signaling pathways regulating pluripotency of stem cells -0.465217391 -0.437747036 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Small cell lung cancer -0.471304348 -0.654150198 -0.609266409 kegg kegg NA NA no up up no no up Hypertrophic cardiomyopathy SNARE interactions in vesicular transport 0 -0.656126482 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Spinocerebellar ataxia -0.874782609 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Spliceosome -0.66 -0.551383399 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Staphylococcus aureus infection 0.419130435 0 0 kegg kegg NA NA no up up up no no Hypertrophic cardiomyopathy Starch and sucrose metabolism 0 -0.480237154 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Steroid hormone biosynthesis 0 0.451581028 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Sulfur metabolism 0.459130435 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy T cell receptor signaling pathway 0 -0.72826087 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Taurine and hypotaurine metabolism -0.406086957 -0.577075099 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Terpenoid backbone biosynthesis -0.522608696 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy TGF-beta signaling pathway 0 0.450592885 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Thermogenesis 0 0.580039526 0.467953668 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Thiamine metabolism 0 0 -0.460746461 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Thyroid hormone signaling pathway 0.786956522 0.911067194 0.834491634 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Tight junction 0.786956522 0.863636364 0.692921493 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy TNF signaling pathway -0.422608696 -0.621541502 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Toll-like receptor signaling pathway 0 -0.575098814 0 yes kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Transcriptional misregulation in cancer -0.765217391 -0.833003953 -0.702702703 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Tryptophan metabolism 0 0.445652174 0 kegg kegg NA NA no up up no up no Hypertrophic cardiomyopathy Type I diabetes mellitus 0.468695652 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Type II diabetes mellitus -0.492173913 -0.666007905 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Tyrosine metabolism 0 0.570158103 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy "Valine, leucine and isoleucine degradation" 0 0.441699605 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Various types of N-glycan biosynthesis -0.453913043 0 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Vascular smooth muscle contraction 0 0.614624506 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Vasopressin-regulated water reabsorption 0 0.548418972 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Vibrio cholerae infection 0.87826087 0.925889328 0.856113256 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Viral protein interaction with cytokine and cytokine receptor 0 0 0.514543115 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Wnt signaling pathway 0 0.464426877 0 kegg kegg NA NA no up up no no no Hypertrophic cardiomyopathy Yersinia infection 0.556521739 0 0.712998713 kegg kegg NA NA no up up no no no Hypotaurine+blood "12,13-EPOME+blood" 0 0 0.481162717 serum_aminoacids serum_ARA 0.933 0.901 no no no no no no Hypotaurine+blood 13-HODE+blood 0 0.56372549 0.428376068 serum_aminoacids serum_ARA 0.933 0.32 no no no no no no Hypotaurine+blood 14:0/18:2-PC+blood -0.493233083 0 0 serum_aminoacids serum_phospholipids 0.933 0.102 no no no no up no Hypotaurine+blood 16:0/18:0-PS+blood 0 -0.656862745 0 serum_aminoacids serum_phospholipids 0.933 0.377 no no no no no no Hypotaurine+blood 16:0/20:4-PI+blood 0 -0.556372549 0 serum_aminoacids serum_phospholipids 0.933 0.558 no no no no no no Hypotaurine+blood 16:0/22:0-PE+blood -0.682706767 0 0 serum_aminoacids serum_phospholipids 0.933 0.00839 no no no dn no up Hypotaurine+blood 16:0/22:6-PC+blood -0.562406015 0 0 serum_aminoacids serum_phospholipids 0.933 4.53E-05 no no no no up up Hypotaurine+blood 18:0-LPC+blood -0.57593985 0 0 serum_aminoacids serum_phospholipids 0.933 0.554 no no no no no no Hypotaurine+blood 18:0/18:0-PC+blood 0 -0.492647059 0 serum_aminoacids serum_phospholipids 0.933 0.426 no no no no no no Hypotaurine+blood 18:0/18:0-PS+blood 0 -0.759803922 0 serum_aminoacids serum_phospholipids 0.933 0.00617 no no no no up no Hypotaurine+blood 18:0/18:1-PC+blood 0 -0.507352941 0 serum_aminoacids serum_phospholipids 0.933 0.393 no no no no no no Hypotaurine+blood 18:0/20:3-PC+blood -0.556390977 0 0 serum_aminoacids serum_phospholipids 0.933 0.0682 no no no no up no Hypotaurine+blood 18:0/22:6-PC+blood -0.787969925 -0.517156863 0 serum_aminoacids serum_phospholipids 0.933 0.0775 no no no no no up Hypotaurine+blood 18:0/22:6-PE+blood 0 -0.549019608 0 serum_aminoacids serum_phospholipids 0.933 0.00022 no no no up up no Hypotaurine+blood 18:0/22:6-PI+blood -0.645112782 -0.620098039 0 serum_aminoacids serum_phospholipids 0.933 0.425 no no no no no no Hypotaurine+blood 18:1-LPE+blood 0 0.487745098 0 serum_aminoacids serum_phospholipids 0.933 0.117 no no no no no no Hypotaurine+blood 18:1/18:0-PS+blood 0 -0.549019608 0 serum_aminoacids serum_phospholipids 0.933 0.193 no no no no no no Hypotaurine+blood 18:1/18:1-PG+blood 0 -0.590686275 0 serum_aminoacids serum_phospholipids 0.933 0.00352 no no no no up up Hypotaurine+blood 18:2/20:4-PC+blood -0.476691729 0 0 serum_aminoacids serum_phospholipids 0.933 0.0145 no no no no no up Hypotaurine+blood 20:0/20:4-PE+blood 0.469172932 0 0 serum_aminoacids serum_phospholipids 0.933 0.00128 no no no up up no Hypotaurine+blood 20:1/20:4-PC+blood -0.806015038 0 0 serum_aminoacids serum_phospholipids 0.933 0.0419 no no no no no up Hypotaurine+blood 20:2-LPC+blood 0 0.529411765 0 serum_aminoacids serum_phospholipids 0.933 0.119 no no no no no up Hypotaurine+blood 20:2/18:0-PC+blood -0.551879699 0 0 serum_aminoacids serum_phospholipids 0.933 0.0427 no no no no up no Hypotaurine+blood 20:2/18:3-PE+blood 0.572932331 0 0 serum_aminoacids serum_phospholipids 0.933 0.0391 no no no up up no Hypotaurine+blood 20:3-LPE+blood 0.485714286 0 0 serum_aminoacids serum_phospholipids 0.933 0.084 no no no no up no Hypotaurine+blood 20:4-LPA+blood 0 0 0.545299145 serum_aminoacids serum_phospholipids 0.933 0.398 no no no no no no Hypotaurine+blood 20:5/18:0-PC+blood -0.70075188 0 0 serum_aminoacids serum_phospholipids 0.933 3.97E-06 no no no no up up Hypotaurine+blood 22:0/16:0-PE+blood -0.590977444 0 0 serum_aminoacids serum_phospholipids 0.933 0.091 no no no no no up Hypotaurine+blood 22:6-LPC+blood -0.533834586 0 0 serum_aminoacids serum_phospholipids 0.933 0.127 no no no no no up Hypotaurine+blood 22:6n3+blood -0.610526316 0 0 serum_aminoacids serum_fattyacid 0.933 0.792 no no no no no no Hypotaurine+blood 24:0+blood 0 0 -0.438632479 serum_aminoacids serum_fattyacid 0.933 0.034 no no no dn no up Hypotaurine+blood 3-(3-Hydroxyphenyl)propanoic acid+stool -0.642857143 0 0 serum_aminoacids stool_cometabolism 0.933 0.33 no no no no no no Hypotaurine+blood 8-HETE+blood 0 0.693627451 0 serum_aminoacids serum_ARA 0.933 0.741 no no no no no no Hypotaurine+blood Adipocytokine signaling pathway 0 0.514705882 0 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood AGE-RAGE signaling pathway in diabetic complications -0.464912281 0 0 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Arachidonic acid metabolism 0 0 -0.453076923 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Asthma 0 -0.552941176 0 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Autophagy - animal 0 0 0.532307692 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Betaine+blood 0 0.526960784 0 serum_aminoacids serum_choline 0.933 0.857 no no no no no no Hypotaurine+blood Biosynthesis of cofactors 0 0 -0.462307692 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Breast cancer 0 0 0.437692308 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Butyricimonas -0.45101735 0 0 butyrate-producing serum_aminoacids Genus 0.933 0.17 no no no no no no Hypotaurine+blood cAMP signaling pathway 0 0.676470588 0 yes serum_aminoacids kegg 0.933 NA no no no no up up Hypotaurine+blood Central carbon metabolism in cancer 0 0 0.416153846 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Choline metabolism in cancer 0 0 0.541538462 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Choline+blood 0 0.720588235 0 serum_aminoacids serum_choline 0.933 0.0395 no no no no up no Hypotaurine+blood Chronic myeloid leukemia 0 0.532352941 0 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Clostridium -0.488905638 -0.645077415 0 serum_aminoacids Genus 0.933 0.925 no no no no no no Hypotaurine+blood Cocaine addiction 0 0 -0.421538462 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Colorectal cancer 0 0 0.51 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Cytosolic DNA-sensing pathway 0 0.502941176 0 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood DHA+blood -0.527819549 0 0 serum_aminoacids serum_ARA 0.933 0.872 no no no no no no Hypotaurine+blood Endocrine and other factor-regulated calcium reabsorption 0 0 -0.423846154 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood EPA+blood -0.466165414 0 0 serum_aminoacids serum_ARA 0.933 0.212 no no no no no no Hypotaurine+blood ErbB signaling pathway 0 0 0.449230769 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Ethanolamine+blood 0 0.50245098 0 serum_aminoacids serum_aminoacids 0.933 0.122 no no no up no no Hypotaurine+blood Ferroptosis 0 0.555882353 -0.52 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood FoxO signaling pathway 0 0 0.484615385 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Gap junction 0 0.685294118 0 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Gastric cancer 0 0 0.463846154 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood GDCA+blood 0 0.674019608 0 serum_aminoacids serum_bileacids 0.933 0.632 no no no no no no Hypotaurine+blood Glioma 0 0 0.583846154 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Glutathione metabolism 0 0 -0.493076923 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood "Glycine, serine and threonine metabolism" 0 0 -0.463076923 serum_aminoacids kegg 0.933 NA no no no no up no Hypotaurine+blood Glycine+blood 0.506766917 0.588235294 0 serum_aminoacids serum_aminoacids 0.933 0.00408 no no no dn no up Hypotaurine+blood GPC+blood 0 0.659313725 0 serum_aminoacids serum_choline 0.933 0.00427 no no no no up up Hypotaurine+blood HDCA+blood 0 0.493782977 0 serum_aminoacids serum_bileacids 0.933 0.483 no no no no no no Hypotaurine+blood Inflammatory bowel disease 0 -0.564705882 0 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Kaposi sarcoma-associated herpesvirus infection 0 0 -0.630769231 serum_aminoacids kegg 0.933 NA no no no no no dn Hypotaurine+blood Long-term depression 0 0.679411765 -0.423846154 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Long-term potentiation -0.466666667 0 0 serum_aminoacids kegg 0.933 NA no no no no no up Hypotaurine+blood Malaria 0 0.6 -0.473846154 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood MAPK signaling pathway 0 0 0.536153846 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood MicroRNAs in cancer 0 0 0.51 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Mineral absorption 0 0.526470588 -0.524615385 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Mitophagy - animal 0 0 -0.456923077 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Necroptosis 0 0.517647059 -0.48 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Non-small cell lung cancer 0 0 0.543076923 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Oocyte meiosis 0 -0.588235294 0 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Pancreatic cancer 0 0 0.587692308 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Pathways in cancer 0 0.532352941 0 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Phosphatidylinositol signaling system 0 0 0.526153846 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Porphyrin and chlorophyll metabolism 0 0 -0.490769231 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Progesterone-mediated oocyte maturation 0 0 0.592307692 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Prostate cancer 0 0.558823529 0 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Proteasome 0 -0.602941176 0 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Relaxin signaling pathway 0 0.664705882 0 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Ruminococcus -0.445467329 0 0 serum_aminoacids Genus 0.933 0.0679 no no no no no dn Hypotaurine+blood Serotonergic synapse 0 0.505882353 0 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Shigellosis 0 0 -0.511538462 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Signaling pathways regulating pluripotency of stem cells 0 0 0.494615385 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Sphingolipid signaling pathway 0 0 0.656153846 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Spinocerebellar ataxia 0 0 0.415384615 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Thyroid hormone synthesis 0 0 -0.600769231 serum_aminoacids kegg 0.933 NA no no no no no no Hypotaurine+blood Ubiquitin mediated proteolysis 0 0 -0.45 serum_aminoacids kegg 0.933 NA no no no no no no IL-13 FGF basic -0.637362637 0 0 yes serum_cytokines serum_cytokines 0.00264 0.65 up up no no no no IL-13 GM-CSF 0.604395604 0.675324675 0.471412681 yes yes serum_cytokines serum_cytokines 0.00264 0.0124 up up no up no no IL-17 signaling pathway 2-Oxocarboxylic acid metabolism -0.45826087 -0.707509881 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Adrenergic signaling in cardiomyocytes 0 -0.649209486 -0.51969112 kegg kegg NA NA no no no no no up IL-17 signaling pathway "Alanine, aspartate and glutamate metabolism" 0.645217391 0.717391304 0.651222651 kegg kegg NA NA no no no no no no IL-17 signaling pathway Aminoacyl-tRNA biosynthesis 0 -0.656126482 -0.536422136 kegg kegg NA NA no no no no no no IL-17 signaling pathway AMPK signaling pathway -0.62173913 -0.563241107 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Antifolate resistance 0 -0.659090909 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Apelin signaling pathway 0 -0.542490119 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Apoptosis 0.442608696 0.766798419 0.619305019 kegg kegg NA NA no no no no no no IL-17 signaling pathway Arginine and proline metabolism 0.602608696 0.736166008 0.744144144 kegg kegg NA NA no no no no up no IL-17 signaling pathway Arginine biosynthesis 0.694782609 0.746047431 0.731016731 kegg kegg NA NA no no no no no no IL-17 signaling pathway Autophagy - animal 0.524347826 0.492094862 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Basal transcription factors 0 -0.695652174 -0.571685972 kegg kegg NA NA no no no no no no IL-17 signaling pathway Base excision repair 0 -0.765810277 -0.637837838 kegg kegg NA NA no no no no no no IL-17 signaling pathway Biosynthesis of amino acids 0 0.839920949 0.733590734 kegg kegg NA NA no no no no no no IL-17 signaling pathway Biosynthesis of cofactors -0.687826087 -0.686758893 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Butanoate metabolism 0 -0.60770751 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway C-type lectin receptor signaling pathway 0.662608696 0.68972332 0.573745174 kegg kegg NA NA no no no no no no IL-17 signaling pathway Calcium signaling pathway 0 -0.427865613 0 kegg kegg NA NA no no no no up up IL-17 signaling pathway Carbon metabolism 0 0 0.574259974 kegg kegg NA NA no no no no no no IL-17 signaling pathway Cardiac muscle contraction 0 -0.552371542 -0.491119691 kegg kegg NA NA no no no no no up IL-17 signaling pathway Cell adhesion molecules 0 0.603754941 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Cell cycle 0 -0.910079051 -0.808751609 kegg kegg NA NA no no no no no no IL-17 signaling pathway Cellular senescence 0 0.591897233 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway cGMP-PKG signaling pathway 0.756521739 0.925889328 0.597168597 kegg kegg NA NA no no no no no no IL-17 signaling pathway Chemokine signaling pathway 0.48173913 0.712450593 0.461776062 kegg kegg NA NA no no no no no no IL-17 signaling pathway Citrate cycle (TCA cycle) -0.414782609 -0.57312253 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Complement and coagulation cascades 0 0.852766798 0.493693694 kegg kegg NA NA no no no no no no IL-17 signaling pathway Cysteine and methionine metabolism 0 -0.541501976 -0.6 kegg kegg NA NA no no no no no no IL-17 signaling pathway Cytokine-cytokine receptor interaction 0 0.442687747 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway DNA replication -0.410434783 -0.807312253 -0.571685972 kegg kegg NA NA no no no no no no IL-17 signaling pathway Drug metabolism - cytochrome P450 0 -0.625494071 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Drug metabolism - other enzymes 0 -0.524703557 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway ECM-receptor interaction -0.559130435 -0.443675889 -0.448391248 kegg kegg NA NA no no no no up up IL-17 signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.463438735 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Endocytosis 0 0.622529644 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Ether lipid metabolism 0 -0.658102767 -0.546203346 kegg kegg NA NA no no no no no no IL-17 signaling pathway Fanconi anemia pathway 0 -0.703557312 -0.626254826 kegg kegg NA NA no no no no no no IL-17 signaling pathway Fatty acid biosynthesis 0.656521739 0.783596838 0.672072072 kegg kegg NA NA no no no no no no IL-17 signaling pathway Fatty acid degradation 0 0.526679842 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Fatty acid metabolism 0 0.600790514 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Folate biosynthesis 0 -0.526679842 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway FoxO signaling pathway 0.452173913 0 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Galactose metabolism 0 0.42687747 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Glutathione metabolism -0.609565217 -0.565217391 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Glycerophospholipid metabolism 0 0 -0.446846847 kegg kegg NA NA no no no no no up IL-17 signaling pathway "Glycine, serine and threonine metabolism" -0.675652174 -0.542490119 0 kegg kegg NA NA no no no no up no IL-17 signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.632173913 0.462450593 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.636363636 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0 -0.434782609 -0.466666667 kegg kegg NA NA no no no no no no IL-17 signaling pathway Glycosaminoglycan degradation 0.583478261 0.625494071 0 kegg kegg NA NA no no no no no up IL-17 signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 -0.618577075 -0.523809524 kegg kegg NA NA no no no no no no IL-17 signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.544466403 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Glyoxylate and dicarboxylate metabolism 0.550434783 0.782608696 0.768082368 kegg kegg NA NA no no no no no no IL-17 signaling pathway Hedgehog signaling pathway 0 -0.755928854 -0.575032175 kegg kegg NA NA no no no no no no IL-17 signaling pathway Hippo signaling pathway - multiple species 0.690434783 0.489130435 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Homologous recombination 0 -0.498023715 -0.646589447 kegg kegg NA NA no no no no no no IL-17 signaling pathway Inositol phosphate metabolism 0 0 -0.485456885 kegg kegg NA NA no no no no no no IL-17 signaling pathway Linoleic acid metabolism 0 -0.435770751 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Lysine degradation 0 -0.638339921 -0.554182754 kegg kegg NA NA no no no no no no IL-17 signaling pathway Lysosome 0.724347826 0.89229249 0.811840412 kegg kegg NA NA no no no no no no IL-17 signaling pathway Mannose type O-glycan biosynthesis 0 -0.529644269 -0.557271557 kegg kegg NA NA no no no no no no IL-17 signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.513833992 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Mismatch repair 0 -0.627470356 -0.426512227 kegg kegg NA NA no no no no no no IL-17 signaling pathway Mitophagy - animal 0 -0.41798419 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway mRNA surveillance pathway 0 -0.813241107 -0.631917632 kegg kegg NA NA no no no no no no IL-17 signaling pathway mTOR signaling pathway 0 -0.466403162 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway N-Glycan biosynthesis -0.453913043 -0.836956522 -0.732561133 kegg kegg NA NA no no no no no no IL-17 signaling pathway Natural killer cell mediated cytotoxicity 0 0.622529644 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Neuroactive ligand-receptor interaction 0.526956522 0.758893281 0.797683398 kegg kegg NA NA no no no up up up IL-17 signaling pathway Neutrophil extracellular trap formation 0.63826087 0.853754941 0.731531532 kegg kegg NA NA no no no no no no IL-17 signaling pathway NF-kappa B signaling pathway 0.526086957 0.514822134 0.465379665 kegg kegg NA NA no no no no no no IL-17 signaling pathway Nicotinate and nicotinamide metabolism 0.717391304 0.835968379 0.9001287 kegg kegg NA NA no no no no no no IL-17 signaling pathway Nitrogen metabolism 0.613913043 0.701581028 0.672329472 kegg kegg NA NA no no no no no no IL-17 signaling pathway NOD-like receptor signaling pathway 0.693913043 0.681818182 0.454311454 kegg kegg NA NA no no no no no no IL-17 signaling pathway Nucleotide excision repair -0.409565217 -0.790513834 -0.651480051 kegg kegg NA NA no no no no no no IL-17 signaling pathway One carbon pool by folate -0.493043478 -0.793478261 -0.737194337 kegg kegg NA NA no no no no no no IL-17 signaling pathway Oocyte meiosis 0 0 -0.613899614 kegg kegg NA NA no no no no no no IL-17 signaling pathway Osteoclast differentiation 0.840869565 0.871541502 0.926383526 kegg kegg NA NA no no no no no no IL-17 signaling pathway Other types of O-glycan biosynthesis 0 -0.640316206 -0.616988417 kegg kegg NA NA no no no no no no IL-17 signaling pathway Oxidative phosphorylation 0 -0.518774704 -0.41956242 kegg kegg NA NA no no no no no no IL-17 signaling pathway p53 signaling pathway 0 0 -0.418790219 kegg kegg NA NA no no no no no no IL-17 signaling pathway Pantothenate and CoA biosynthesis 0.814782609 0.780632411 0.768082368 kegg kegg NA NA no no no no no dn IL-17 signaling pathway Paraprevotella 0 -0.494773936 0 kegg Genus NA 0.118 no no no no no no IL-17 signaling pathway Pentose and glucuronate interconversions 0 -0.747035573 -0.581209781 kegg kegg NA NA no no no no no no IL-17 signaling pathway Pentose phosphate pathway 0.569565217 0.908102767 0.866151866 kegg kegg NA NA no no no no no no IL-17 signaling pathway Peroxisome 0.510434783 0.75 0.576319176 kegg kegg NA NA no no no no no no IL-17 signaling pathway Phagosome 0 0.752964427 0.499356499 kegg kegg NA NA no no no no no no IL-17 signaling pathway Phenylalanine metabolism -0.480869565 -0.5 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Phosphatidylinositol signaling system 0 -0.552371542 -0.572972973 kegg kegg NA NA no no no no no no IL-17 signaling pathway Phospholipase D signaling pathway 0.406956522 0.440711462 0 kegg kegg NA NA no no no no up up IL-17 signaling pathway Platinum drug resistance 0 0 -0.475933076 kegg kegg NA NA no no no no no no IL-17 signaling pathway Porphyrin and chlorophyll metabolism -0.630434783 -0.459486166 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway PPAR signaling pathway 0.514782609 0.769762846 0.803603604 kegg kegg NA NA no no no no no no IL-17 signaling pathway Prevotella -0.404859139 0 0 acetate-producing kegg Genus NA 0.287 no no no no no no IL-17 signaling pathway Propanoate metabolism 0 -0.43972332 -0.441184041 kegg kegg NA NA no no no no no no IL-17 signaling pathway Protein export 0 -0.603754941 -0.527927928 kegg kegg NA NA no no no no no no IL-17 signaling pathway Protein processing in endoplasmic reticulum -0.588695652 -0.896245059 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Purine metabolism -0.58 -0.645256917 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Pyrimidine metabolism 0 -0.742094862 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Pyruvate metabolism 0 -0.595849802 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Ras signaling pathway 0 -0.645256917 -0.503732304 yes kegg kegg NA NA no no no no up up IL-17 signaling pathway Renin-angiotensin system 0.73826087 0.858695652 0.685714286 kegg kegg NA NA no no no no no no IL-17 signaling pathway Retinol metabolism 0 -0.544466403 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Ribosome -0.44 -0.435770751 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Ribosome biogenesis in eukaryotes -0.416521739 -0.845849802 -0.721492921 kegg kegg NA NA no no no no no no IL-17 signaling pathway RIG-I-like receptor signaling pathway 0.679130435 0.533596838 0.427284427 kegg kegg NA NA no no no no no no IL-17 signaling pathway RNA degradation 0 -0.82312253 -0.624967825 kegg kegg NA NA no no no no no no IL-17 signaling pathway RNA polymerase 0 -0.898221344 -0.637065637 kegg kegg NA NA no no no no no no IL-17 signaling pathway Ruminococcus -0.60173913 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no IL-17 signaling pathway Selenocompound metabolism 0 -0.493083004 -0.468983269 kegg kegg NA NA no no no no no no IL-17 signaling pathway Signaling pathways regulating pluripotency of stem cells 0 0 -0.452252252 kegg kegg NA NA no no no no no no IL-17 signaling pathway Sphingolipid metabolism 0.446956522 0 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Sphingolipid signaling pathway 0.507826087 0.572134387 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Spliceosome 0 -0.537549407 -0.594851995 kegg kegg NA NA no no no no no no IL-17 signaling pathway Starch and sucrose metabolism 0.586956522 0.731225296 0.477220077 kegg kegg NA NA no no no no no no IL-17 signaling pathway Steroid biosynthesis 0 0 -0.58043758 kegg kegg NA NA no no no no no no IL-17 signaling pathway Synthesis and degradation of ketone bodies 0 -0.614624506 -0.509137709 kegg kegg NA NA no no no no no no IL-17 signaling pathway Terpenoid backbone biosynthesis 0 -0.461462451 -0.524066924 kegg kegg NA NA no no no no no no IL-17 signaling pathway TGF-beta signaling pathway 0 -0.482213439 -0.469498069 kegg kegg NA NA no no no no no no IL-17 signaling pathway Thiamine metabolism 0 -0.461462451 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Toll-like receptor signaling pathway 0.610434783 0.779644269 0.655341055 yes kegg kegg NA NA no no no no no no IL-17 signaling pathway Tyrosine metabolism -0.473043478 -0.555335968 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.622529644 -0.543629344 kegg kegg NA NA no no no no no no IL-17 signaling pathway Ubiquitin mediated proteolysis -0.459130435 -0.562252964 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway "Valine, leucine and isoleucine degradation" 0 -0.618577075 -0.427284427 kegg kegg NA NA no no no no no no IL-17 signaling pathway Various types of N-glycan biosynthesis 0 -0.739130435 -0.544401544 kegg kegg NA NA no no no no no no IL-17 signaling pathway VEGF signaling pathway 0.436521739 0 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Viral protein interaction with cytokine and cytokine receptor 0 0.5256917 0 kegg kegg NA NA no no no no no no IL-17 signaling pathway Wnt signaling pathway 0 -0.852766798 -0.558558559 kegg kegg NA NA no no no no no no IL-17A Eotaxin 0 0 0.430478309 serum_cytokines serum_cytokines 0.855 0.393 no no no no no no IL-17A FGF basic 0.664835165 0.585714286 0.402892102 serum_cytokines serum_cytokines 0.855 0.65 no no no no no no IL-17A GM-CSF -0.708791209 -0.474025974 -0.413125695 yes serum_cytokines serum_cytokines 0.855 0.0124 no no no up no no IL-17A IL-13 -0.93956044 0 0 yes serum_cytokines serum_cytokines 0.855 0.00264 no no no up up no IL-1b GM-CSF 0 0 0.563070078 yes yes serum_cytokines serum_cytokines 0.00358 0.0124 up up no up no no IL-1b IFN-g -0.642857143 -0.444155844 0 yes serum_cytokines serum_cytokines 0.00358 0.825 up up no no no no IL-1b IL-13 0.857142857 0.738961039 0.688542825 yes yes serum_cytokines serum_cytokines 0.00358 0.00264 up up no up up no IL-1b IL-17A -0.89010989 -0.572727273 0 yes serum_cytokines serum_cytokines 0.00358 0.855 up up no no no no IL-1ra 12-ketoDCA+stool 0 -0.644484351 0 yes serum_cytokines stool_bileacids 0.0288 0.505 no up no no no no IL-1ra 16:0/18:2-PI+blood 0 0.542857143 0 yes serum_cytokines serum_phospholipids 0.0288 0.269 no up no no no no IL-1ra 16:0/20:3-PC+blood -0.636363636 0 0 yes serum_cytokines serum_phospholipids 0.0288 5.43E-06 no up no no up up IL-1ra 16:0/20:4-PC+blood 0 -0.582142857 0 yes serum_cytokines serum_phospholipids 0.0288 0.0262 no up no no up no IL-1ra 16:0/20:4-PI+blood 0 0.689285714 0 yes serum_cytokines serum_phospholipids 0.0288 0.558 no up no no no no IL-1ra 16:0/20:5-PC+blood 0 0 0.523308271 yes serum_cytokines serum_phospholipids 0.0288 0.628 no up no no no no IL-1ra 18:0/18:0-PC+blood 0 0.532142857 0 yes serum_cytokines serum_phospholipids 0.0288 0.426 no up no no no no IL-1ra 18:0/18:1-PC+blood 0 0.514285714 0 yes serum_cytokines serum_phospholipids 0.0288 0.393 no up no no no no IL-1ra 18:0/18:2-PI+blood 0 0.514285714 0 yes serum_cytokines serum_phospholipids 0.0288 0.179 no up no no no no IL-1ra 18:0/20:3-PI+blood 0 0 -0.479699248 yes serum_cytokines serum_phospholipids 0.0288 0.377 no up no no no no IL-1ra 18:0/20:5-PC+blood 0 0 0.466165414 yes serum_cytokines serum_phospholipids 0.0288 0.17 no up no no no no IL-1ra 18:0/22:6-PA+blood 0 0.546428571 0 yes serum_cytokines serum_phospholipids 0.0288 0.22 no up no no no no IL-1ra 18:0/22:6-PE+blood 0 0 0.563909774 yes serum_cytokines serum_phospholipids 0.0288 0.00022 no up no up up no IL-1ra 18:1-LPC+blood -0.636363636 0 0 yes serum_cytokines serum_phospholipids 0.0288 0.179 no up no no no no IL-1ra 18:1/20:3-PC+blood -0.709090909 0 0 yes serum_cytokines serum_phospholipids 0.0288 0.00872 no up no no up up IL-1ra 18:2/20:4-PC+blood 0 -0.557142857 0 yes serum_cytokines serum_phospholipids 0.0288 0.0145 no up no no no up IL-1ra 20:0/20:5-PC+blood 0 0 0.547368421 yes serum_cytokines serum_phospholipids 0.0288 0.882 no up no no no no IL-1ra 20:1+blood -0.76969697 0 -0.590977444 yes yes serum_cytokines serum_fattyacid 0.0288 2.56E-05 no up no dn dn dn IL-1ra 20:3/16:0-PC+blood 0 -0.532142857 0 yes serum_cytokines serum_phospholipids 0.0288 0.00405 no up no no up up IL-1ra 24:0+blood 0.660606061 0 0 yes serum_cytokines serum_fattyacid 0.0288 0.034 no up no dn no up IL-1ra Adrenergic signaling in cardiomyocytes 0 -0.461654135 0 yes serum_cytokines kegg 0.0288 NA no up no no no up IL-1ra Aldosterone synthesis and secretion 0 -0.603007519 0 yes serum_cytokines kegg 0.0288 NA no up no no up up IL-1ra Betaine+blood -0.684848485 0 0 yes serum_cytokines serum_choline 0.0288 0.857 no up no no no no IL-1ra Breast cancer -0.598901099 0 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Calcium signaling pathway -0.587912088 -0.478195489 0 yes serum_cytokines kegg 0.0288 NA no up no no up up IL-1ra Carbon metabolism 0.587912088 0.590977444 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra CDCA+stool 0 0.594405594 0 yes serum_cytokines stool_bileacids 0.0288 0.663 no up no no no no IL-1ra Cell adhesion molecules 0 0.506766917 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Chemical carcinogenesis - receptor activation 0 -0.607518797 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Choline+blood -0.660606061 0 0 yes serum_cytokines serum_choline 0.0288 0.0395 no up no no up no IL-1ra Clostridium 0 0.506472394 0 yes serum_cytokines Genus 0.0288 0.925 no up no no no no IL-1ra Cocaine addiction 0 -0.571428571 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Colorectal cancer -0.675824176 0 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Cortisol synthesis and secretion 0 -0.589473684 0 yes serum_cytokines kegg 0.0288 NA no up no no no up IL-1ra Cushing syndrome 0 -0.661654135 0 yes serum_cytokines kegg 0.0288 NA no up no no no up IL-1ra Endocrine and other factor-regulated calcium reabsorption 0 -0.463157895 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Endocrine resistance 0 -0.62556391 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Gap junction 0 -0.488721805 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra GCA+stool 0 0.664335664 0 yes serum_cytokines stool_bileacids 0.0288 0.0809 no up no no no no IL-1ra GDCA+blood 0 -0.546428571 0 yes serum_cytokines serum_bileacids 0.0288 0.632 no up no no no no IL-1ra Glucagon signaling pathway 0 -0.472180451 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Glycolysis / Gluconeogenesis 0.67032967 0 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra GM-CSF 0 0 0.409121246 yes yes serum_cytokines serum_cytokines 0.0288 0.0124 no up no up no no IL-1ra GnRH signaling pathway 0 -0.70075188 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra GPC+blood 0 0 0.509774436 yes serum_cytokines serum_choline 0.0288 0.00427 no up no no up up IL-1ra "Growth hormone synthesis, secretion and action" 0 -0.565413534 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra HDCA+stool 0 -0.594405594 0 yes serum_cytokines stool_bileacids 0.0288 0.176 no up no no no no IL-1ra Hypotaurine+blood 0 -0.610714286 0 yes serum_cytokines serum_aminoacids 0.0288 0.933 no up no no no no IL-1ra IL-17A 0 0 -0.688097887 yes serum_cytokines serum_cytokines 0.0288 0.855 no up no no no no IL-1ra Insulin secretion 0 -0.658646617 0 yes yes serum_cytokines kegg 0.0288 NA no up no no up up IL-1ra iso-DCA+blood -0.660606061 -0.553571429 0 yes serum_cytokines serum_bileacids 0.0288 0.38 no up no no no no IL-1ra iso-LCA+stool 0 -0.797202797 0 yes serum_cytokines stool_bileacids 0.0288 0.72 no up no no no no IL-1ra L-2-Aminobutyric acid+blood 0 0 -0.542857143 yes yes serum_cytokines serum_aminoacids 0.0288 0.000328 no up no up up no IL-1ra L-Alanine+blood 0 -0.55 0 yes yes serum_cytokines serum_aminoacids 0.0288 0.00138 no up no up up no IL-1ra L-Arginine+blood -0.793939394 0 0 yes serum_cytokines serum_aminoacids 0.0288 0.316 no up no no no no IL-1ra L-Homocystine+blood -0.648484848 0 0 yes serum_cytokines serum_aminoacids 0.0288 0.197 no up no no no no IL-1ra L-Methionine+blood -0.672727273 0 0 yes serum_cytokines serum_aminoacids 0.0288 0.626 no up no no no no IL-1ra L-Phenylalanine+blood -0.709090909 0 0 yes yes serum_cytokines serum_aminoacids 0.0288 0.0103 no up no up up no IL-1ra L-Tryptophan+blood -0.818181818 0 0 yes serum_cytokines serum_aminoacids 0.0288 0.164 no up no no no no IL-1ra L-Tyrosine+blood -0.806060606 0 0 yes yes serum_cytokines serum_aminoacids 0.0288 0.00913 no up no up up no IL-1ra LCA+stool 0 -0.818181818 0 yes serum_cytokines stool_bileacids 0.0288 0.314 no up no no no no IL-1ra Legionellosis 0.642857143 0 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Long-term depression 0 -0.478195489 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Longevity regulating pathway - multiple species 0 0.544360902 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Melanogenesis 0 -0.497744361 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra P-hydroxyhippuric acid+urine 0 -0.5 0 yes serum_cytokines urine_cometabolism 0.0288 0.436 no up no no no no IL-1ra Pancreatic secretion 0 -0.506766917 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra "Parathyroid hormone synthesis, secretion and action" 0 -0.47518797 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Phagosome 0 0.446616541 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Phenylacetic acid+stool -0.842424242 0 -0.632352941 yes serum_cytokines stool_cometabolism 0.0288 0.785 no up no no no no IL-1ra Phospholipase D signaling pathway -0.576923077 0 0 yes serum_cytokines kegg 0.0288 NA no up no no up up IL-1ra Primary immunodeficiency 0.626373626 0 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Proteasome 0 0 -0.459770115 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Regulation of lipolysis in adipocytes 0 -0.497744361 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Salivary secretion 0 0 0.49589491 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra Salmonella infection 0 0.645112782 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra TDCA+blood 0 -0.523784927 0 yes yes serum_cytokines serum_bileacids 0.0288 0.155 no up no no up no IL-1ra Thyroid hormone synthesis 0 -0.485714286 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-1ra UDCA+stool 0 0.594405594 0 yes serum_cytokines stool_bileacids 0.0288 0.266 no up no no no no IL-1ra Vasopressin-regulated water reabsorption 0 -0.452631579 0 yes serum_cytokines kegg 0.0288 NA no up no no no no IL-2 IFN-g 0.653846154 0.666233766 0.461179088 serum_cytokines serum_cytokines 0.522 0.825 no no no no no no IL-2 IL-13 -0.604395604 0 0 yes serum_cytokines serum_cytokines 0.522 0.00264 no no no up up no IL-2 IL-1b -0.554945055 -0.516883117 0 yes serum_cytokines serum_cytokines 0.522 0.00358 no no no up up no IL-4 Eotaxin 0.659340659 0.838961039 0.688987764 serum_cytokines serum_cytokines 0.858 0.393 no no no no no no IL-4 GM-CSF -0.664835165 -0.577922078 0 yes serum_cytokines serum_cytokines 0.858 0.0124 no no no up no no IL-4 IL-17A 0 0.611688312 0.799777531 serum_cytokines serum_cytokines 0.858 0.855 no no no no no no IL-4 IL-1ra 0 0 -0.477641824 yes serum_cytokines serum_cytokines 0.858 0.0288 no no no no up no IL-6 Adherens junction 0 0.527819549 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Alistipes 0 -0.50684308 0 serum_cytokines Genus 0.52 0.0114 no no no no up no IL-6 Anaerostipes 0 -0.498193182 0 butyrate-producing serum_cytokines Genus 0.52 0.568 no no no no no no IL-6 Antigen processing and presentation 0 0.445112782 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Asthma 0 0.520300752 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Bacterial invasion of epithelial cells 0 0.613533835 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Carbon metabolism 0 0.541353383 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Cell cycle 0 -0.479699248 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Chemical carcinogenesis - receptor activation 0 -0.469172932 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Clostridium 0 0.454244576 0 serum_cytokines Genus 0.52 0.925 no no no no no no IL-6 Eotaxin 0 -0.571428571 -0.404226919 serum_cytokines serum_cytokines 0.52 0.393 no no no no no no IL-6 Epstein-Barr virus infection 0 0.45112782 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 ErbB signaling pathway 0 -0.509774436 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 FGF basic 0.653846154 0 0 serum_cytokines serum_cytokines 0.52 0.65 no no no no no no IL-6 Fluid shear stress and atherosclerosis 0 0.637593985 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Focal adhesion 0 0.541353383 0 serum_cytokines kegg 0.52 NA no no no no up up IL-6 FoxO signaling pathway 0 -0.487218045 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Gastric cancer 0 -0.609022556 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Hippuric acid+urine 0 -0.717647059 0 serum_cytokines urine_cometabolism 0.52 0.361 no no no no no no IL-6 IFN-g 0 0.849350649 0.576418242 serum_cytokines serum_cytokines 0.52 0.825 no no no no no no IL-6 IL-13 -0.681318681 0 0 yes serum_cytokines serum_cytokines 0.52 0.00264 no no no up up no IL-6 IL-17 signaling pathway 0 0.509774436 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 IL-17A 0.796703297 0 0 serum_cytokines serum_cytokines 0.52 0.855 no no no no no no IL-6 IL-1b -0.741758242 0 0 yes serum_cytokines serum_cytokines 0.52 0.00358 no no no up up no IL-6 IL-2 0 0.78961039 0.430923248 serum_cytokines serum_cytokines 0.52 0.522 no no no no no no IL-6 JAK-STAT signaling pathway 0 -0.515789474 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Leishmaniasis 0 0.521804511 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Leukocyte transendothelial migration 0 0.679699248 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Lysosome 0 0.57443609 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 MAPK signaling pathway 0 -0.473684211 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Non-small cell lung cancer 0 -0.593984962 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Oxytocin signaling pathway 0 0.646616541 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 p53 signaling pathway 0 -0.753383459 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Pancreatic cancer 0 -0.469172932 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Pathogenic Escherichia coli infection 0 0.487218045 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Pathways in cancer 0 -0.539849624 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Phosphatidylinositol signaling system 0 -0.445112782 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Platelet activation 0 0.618045113 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Platinum drug resistance 0 -0.711278195 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Progesterone-mediated oocyte maturation 0 -0.630075188 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Rap1 signaling pathway 0 0.532330827 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Regulation of actin cytoskeleton 0 0.606015038 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Ribosome biogenesis in eukaryotes 0 -0.445112782 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Signaling pathways regulating pluripotency of stem cells 0 -0.508270677 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Spinocerebellar ataxia 0 -0.44962406 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Spliceosome 0 -0.781954887 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Staphylococcus aureus infection 0 0.484210526 0 serum_cytokines kegg 0.52 NA no no no up no no IL-6 Systemic lupus erythematosus 0 0.463157895 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 T cell receptor signaling pathway 0 -0.547368421 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Tight junction 0 0.584962406 0 serum_cytokines kegg 0.52 NA no no no no no no IL-6 Vibrio cholerae infection 0 0.476691729 0 serum_cytokines kegg 0.52 NA no no no no no no IL-8 Eotaxin 0 -0.485714286 0 serum_cytokines serum_cytokines 0.579 0.393 no no no no no no IL-8 GM-CSF 0 0 0.424694105 yes serum_cytokines serum_cytokines 0.579 0.0124 no no no up no no IL-8 IFN-g 0.60989011 0.574025974 0 serum_cytokines serum_cytokines 0.579 0.825 no no no no no no IL-8 IL-17A 0 0 -0.585761958 serum_cytokines serum_cytokines 0.579 0.855 no no no no no no IL-8 IL-1ra 0 0.503896104 0.433147942 yes serum_cytokines serum_cytokines 0.579 0.0288 no no no no up no IL-8 IL-2 0.681318681 0.468831169 0 serum_cytokines serum_cytokines 0.579 0.522 no no no no no no IL-8 IL-4 0 0 -0.509232481 serum_cytokines serum_cytokines 0.579 0.858 no no no no no no IL-8 IL-6 0 0.528571429 0 serum_cytokines serum_cytokines 0.579 0.52 no no no no no no IL-8 Odoribacter 0 0 0.404951476 butyrate-producing serum_cytokines Genus 0.579 0.798 no no no no no no IL-9 12-ketoDCA+blood 0 0.679066556 -0.528378343 serum_cytokines serum_bileacids 0.906 0.517 no no no no no no IL-9 16:0/18:3-PC+blood 0 0 0.547368421 serum_cytokines serum_phospholipids 0.906 0.00216 no no no no up up IL-9 16:1/18:2-PG+blood 0 -0.65 0 serum_cytokines serum_phospholipids 0.906 1.40E-08 no no no no up up IL-9 18:0/18:0-PC+blood 0 0 0.482706767 serum_cytokines serum_phospholipids 0.906 0.426 no no no no no no IL-9 18:0/18:1-PC+blood 0 0 0.488721805 serum_cytokines serum_phospholipids 0.906 0.393 no no no no no no IL-9 18:0/18:2-PI+blood 0 -0.539285714 0 serum_cytokines serum_phospholipids 0.906 0.179 no no no no no no IL-9 18:0/20:3-PI+blood 0 -0.546428571 0 serum_cytokines serum_phospholipids 0.906 0.377 no no no no no no IL-9 18:1/18:1-PE+blood 0.733333333 -0.528571429 0 serum_cytokines serum_phospholipids 0.906 1.03E-05 no no no up up no IL-9 18:1/18:2-PG+blood 0 -0.553571429 0 serum_cytokines serum_phospholipids 0.906 5.58E-07 no no no no up up IL-9 24:1+blood -0.709090909 0 0 serum_cytokines serum_fattyacid 0.906 0.00582 no no no no dn dn IL-9 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.464912281 serum_cytokines urine_cometabolism 0.906 0.0405 no no no no dn dn IL-9 Alcoholism 0 -0.44962406 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Antigen processing and presentation 0 -0.54887218 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Chemical carcinogenesis - receptor activation 0 0.45112782 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Clostridium 0.574594405 -0.547704882 0 serum_cytokines Genus 0.906 0.925 no no no no no no IL-9 Cystine+blood -0.76969697 0 0 yes serum_cytokines serum_aminoacids 0.906 0.00028 no no no up up no IL-9 d18:1-20:0-SM+blood 0.806060606 0 0 serum_cytokines serum_phospholipids 0.906 0.933 no no no no no no IL-9 d18:1-22:0-SM+blood 0.660606061 0 0 serum_cytokines serum_phospholipids 0.906 0.522 no no no no no no IL-9 DCA+stool 0 0 -0.492647059 serum_cytokines stool_bileacids 0.906 0.195 no no no no no no IL-9 Eotaxin -0.565934066 0.537662338 0 serum_cytokines serum_cytokines 0.906 0.393 no no no no no no IL-9 Epstein-Barr virus infection 0 -0.566917293 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 ErbB signaling pathway 0 0.445112782 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Ferroptosis -0.631868132 0 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Gastric cancer 0 0.55037594 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 GCA+stool 0 -0.706293706 0.600490196 serum_cytokines stool_bileacids 0.906 0.0809 no no no no no no IL-9 GCDCA+stool 0 0 0.514705882 yes serum_cytokines stool_bileacids 0.906 0.0471 no no no no dn no IL-9 GDCA+blood 0 0 -0.493233083 serum_cytokines serum_bileacids 0.906 0.632 no no no no no no IL-9 GLCA+blood 0 0.537276633 -0.498298794 serum_cytokines serum_bileacids 0.906 0.319 no no no no no no IL-9 HDCA+blood 0 0 -0.44992027 serum_cytokines serum_bileacids 0.906 0.483 no no no no no no IL-9 HDCA+stool 0 0.608391608 0 serum_cytokines stool_bileacids 0.906 0.176 no no no no no no IL-9 Hematopoietic cell lineage 0 0 -0.499726327 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Herpes simplex virus 1 infection 0 -0.484210526 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Human cytomegalovirus infection 0 -0.512781955 0 serum_cytokines kegg 0.906 NA no no no no no dn IL-9 Human immunodeficiency virus 1 infection 0 -0.547368421 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Human T-cell leukemia virus 1 infection 0 -0.538345865 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Hypotaurine+blood 0 0 -0.448120301 serum_cytokines serum_aminoacids 0.906 0.933 no no no no no no IL-9 IFN-g 0 -0.741558442 0 serum_cytokines serum_cytokines 0.906 0.825 no no no no no no IL-9 IL-2 0 -0.715584416 0 serum_cytokines serum_cytokines 0.906 0.522 no no no no no no IL-9 IL-6 0 -0.727272727 0 serum_cytokines serum_cytokines 0.906 0.52 no no no no no no IL-9 IL-8 0 -0.518181818 -0.661401557 serum_cytokines serum_cytokines 0.906 0.579 no no no no no no IL-9 Influenza A 0 0 -0.468527641 serum_cytokines kegg 0.906 NA no no no no no no IL-9 iso-LCA+stool 0 0.643356643 0 serum_cytokines stool_bileacids 0.906 0.72 no no no no no no IL-9 L-Alanine+blood -0.76969697 0 0 yes serum_cytokines serum_aminoacids 0.906 0.00138 no no no up up no IL-9 L-Asparagine+blood -0.709090909 0 0 serum_cytokines serum_aminoacids 0.906 0.784 no no no no no no IL-9 L-Glutamic acid+blood -0.83030303 0 0.514285714 yes serum_cytokines serum_aminoacids 0.906 6.20E-05 no no no up up no IL-9 L-Glutamine+blood -0.745454545 0 0 serum_cytokines serum_aminoacids 0.906 0.639 no no no no no no IL-9 L-Lysine+blood -0.696969697 0 0 yes serum_cytokines serum_aminoacids 0.906 0.0107 no no no no up no IL-9 L-Methionine+blood -0.636363636 0 0 serum_cytokines serum_aminoacids 0.906 0.626 no no no no no no IL-9 L-Ornithine+blood -0.696969697 0 0 serum_cytokines serum_aminoacids 0.906 0.175 no no no no no no IL-9 LCA+stool 0 0.636363636 0 serum_cytokines stool_bileacids 0.906 0.314 no no no no no no IL-9 Leukocyte transendothelial migration 0 -0.562406015 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Longevity regulating pathway - multiple species 0 0 -0.527093596 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Lysosome 0 -0.479699248 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Malaria -0.615384615 0 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Mineral absorption -0.642857143 0 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Necroptosis -0.659340659 0 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Non-small cell lung cancer 0 0.538345865 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 nutriCA+stool 0 -0.584521537 0 serum_cytokines stool_bileacids 0.906 0.481 no no no no no no IL-9 p53 signaling pathway 0 0.642105263 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Platinum drug resistance 0 0.530827068 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Progesterone-mediated oocyte maturation 0 0.505263158 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Regulation of actin cytoskeleton 0 -0.551879699 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Rheumatoid arthritis 0 0 -0.468527641 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Ruminococcus 0.615384615 0 0 serum_cytokines Genus 0.906 0.0679 no no no no no dn IL-9 Spliceosome 0 0.586466165 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Staphylococcus aureus infection 0 0 -0.464696223 serum_cytokines kegg 0.906 NA no no no up no no IL-9 T cell receptor signaling pathway 0 0.469172932 0 serum_cytokines kegg 0.906 NA no no no no no no IL-9 TCA+stool 0 -0.588442233 0 serum_cytokines stool_bileacids 0.906 0.458 no no no no no no IL-9 TDCA+stool 0 -0.839990637 0 serum_cytokines stool_bileacids 0.906 0.963 no no no no no no IL-9 TLCA+stool 0.668762 0 0 serum_cytokines stool_bileacids 0.906 0.243 no no no no no no IL-9 Toxoplasmosis 0 0 -0.532019704 serum_cytokines kegg 0.906 NA no no no no no no IL-9 Tuberculosis 0 0 -0.490421456 serum_cytokines kegg 0.906 NA no no no no no dn Indole-3-Acetic acid+stool 5-Hydroxytryptamine+stool 0 0.748251748 0.503952569 stool_cometabolism stool_cometabolism 0.304 0.00862 no no no dn dn no Indole-3-Acetic acid+stool Acetic acid+stool 0 0 -0.435770751 yes stool_cometabolism stool_scfa 0.304 0.0656 no no no dn no no Indole-3-Acetic acid+stool Adrenergic signaling in cardiomyocytes 0 0.618181818 0 stool_cometabolism kegg 0.304 NA no no no no no up Indole-3-Acetic acid+stool Antigen processing and presentation 0 -0.645454545 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Asthma 0 -0.772727273 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Blautia 0 -0.671328671 0 acetate-producing stool_cometabolism Genus 0.304 1.36E-05 no no no up dn dn Indole-3-Acetic acid+stool Butyric acid+stool -0.510835913 0 0 yes stool_cometabolism stool_scfa 0.304 0.102 no no no dn no no Indole-3-Acetic acid+stool CA+stool 0 -0.713286713 0 stool_cometabolism stool_bileacids 0.304 0.827 no no no no no no Indole-3-Acetic acid+stool Caproic acid+stool 0 0.664335664 0 stool_cometabolism stool_scfa 0.304 0.882 no no no no no no Indole-3-Acetic acid+stool CDCA+stool 0 -0.769230769 -0.428853755 stool_cometabolism stool_bileacids 0.304 0.663 no no no no no no Indole-3-Acetic acid+stool Clostridium 0 -0.671328671 0 stool_cometabolism Genus 0.304 0.925 no no no no no no Indole-3-Acetic acid+stool Cortisol synthesis and secretion 0 0.7 0 stool_cometabolism kegg 0.304 NA no no no no no up Indole-3-Acetic acid+stool Endocrine resistance 0 0.672727273 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Epstein-Barr virus infection 0 -0.645454545 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Gap junction 0 0.681818182 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool GCA+stool 0 -0.727272727 0 stool_cometabolism stool_bileacids 0.304 0.0809 no no no no no no Indole-3-Acetic acid+stool GCDCA+stool 0 -0.811188811 0 yes stool_cometabolism stool_bileacids 0.304 0.0471 no no no no dn no Indole-3-Acetic acid+stool GDCA+stool 0 -0.732050159 0 stool_cometabolism stool_bileacids 0.304 0.656 no no no no no no Indole-3-Acetic acid+stool Glutamatergic synapse 0 0.790909091 0 stool_cometabolism kegg 0.304 NA no no no no up up Indole-3-Acetic acid+stool Glycolysis / Gluconeogenesis 0 -0.672727273 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool "Growth hormone synthesis, secretion and action" 0 0.754545455 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Herpes simplex virus 1 infection 0 -0.727272727 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Human immunodeficiency virus 1 infection 0 -0.645454545 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Human T-cell leukemia virus 1 infection 0 -0.663636364 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Intestinal immune network for IgA production 0 -0.718181818 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Phospholipase D signaling pathway 0 0.709090909 0 stool_cometabolism kegg 0.304 NA no no no no up up Indole-3-Acetic acid+stool Proteasome 0 -0.654545455 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Regulation of actin cytoskeleton 0 -0.709090909 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Regulation of lipolysis in adipocytes 0 0.709090909 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Serotonergic synapse 0 0.709090909 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Th1 and Th2 cell differentiation 0 -0.609090909 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Th17 cell differentiation 0 -0.618181818 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+stool Toxoplasmosis 0 -0.681818182 0 stool_cometabolism kegg 0.304 NA no no no no no no Indole-3-Acetic acid+urine 12-ketoDCA+stool 0 0 0.680082559 urine_cometabolism stool_bileacids 0.657 0.505 no no no no no no Indole-3-Acetic acid+urine 16:0/18:0-PS+blood 0 0 0.435064935 urine_cometabolism serum_phospholipids 0.657 0.377 no no no no no no Indole-3-Acetic acid+urine 18:1/18:1-PE+blood 0 0 0.525974026 urine_cometabolism serum_phospholipids 0.657 1.03E-05 no no no up up no Indole-3-Acetic acid+urine 18:1/20:3-PC+blood -0.509803922 0 0 urine_cometabolism serum_phospholipids 0.657 0.00872 no no no no up up Indole-3-Acetic acid+urine 3-Hydroxy-L-kynurenine+urine 0 0 -0.439316239 urine_cometabolism urine_cometabolism 0.657 0.401 no no no no no no Indole-3-Acetic acid+urine 3-Hydroxytyramine hydrochloride+urine -0.505263158 0 -0.458461538 urine_cometabolism urine_cometabolism 0.657 0.288 no no no no no no Indole-3-Acetic acid+urine 4-hydroxy-3-methoxymandelic acid+urine -0.592481203 0 0 urine_cometabolism urine_cometabolism 0.657 0.973 no no no no no no Indole-3-Acetic acid+urine 4-hydroxybenzoic acid+urine 0 0.515789474 0 urine_cometabolism urine_cometabolism 0.657 0.52 no no no no no no Indole-3-Acetic acid+urine 8-HETE+blood -0.49754902 0 0 urine_cometabolism serum_ARA 0.657 0.741 no no no no no no Indole-3-Acetic acid+urine Bifidobacterium -0.517293233 0 0 acetate-producing urine_cometabolism Genus 0.657 0.105 no no no no dn no Indole-3-Acetic acid+urine d18:1-20:1-SM+blood -0.485294118 0 0 urine_cometabolism serum_phospholipids 0.657 0.0992 no no no no no no Indole-3-Acetic acid+urine DCA+stool 0.547252747 0 0 urine_cometabolism stool_bileacids 0.657 0.195 no no no no no no Indole-3-Acetic acid+urine Dorea -0.457142857 0 0 urine_cometabolism Genus 0.657 0.00362 no no no up no dn Indole-3-Acetic acid+urine GDCA+blood 0.600490196 0 0 urine_cometabolism serum_bileacids 0.657 0.632 no no no no no no Indole-3-Acetic acid+urine Prevotella 0.60574593 0 0 acetate-producing urine_cometabolism Genus 0.657 0.287 no no no no no no Indole-3-Acetic acid+urine PUFA/MUFA+blood -0.507352941 0 0 urine_cometabolism serum_fattyacid 0.657 0.00108 no no no dn no up Indole-3-Acetic acid+urine PUFA%+blood -0.56372549 0 0 urine_cometabolism serum_fattyacid 0.657 0.0013 no no no dn no up Indole-3-Acetic acid+urine SFA%+blood -0.50245098 0 0 urine_cometabolism serum_fattyacid 0.657 0.0236 no no no no up no Indole-3-Acetic acid+urine UFA%+blood -0.541666667 0 0 urine_cometabolism serum_fattyacid 0.657 0.0236 no no no no dn no Inflammatory bowel disease Adrenergic signaling in cardiomyocytes 0 -0.43972332 0 kegg kegg NA NA no no no no no up Inflammatory bowel disease AGE-RAGE signaling pathway in diabetic complications 0.465217391 0 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Aldosterone synthesis and secretion 0 -0.448616601 0 kegg kegg NA NA no no no no up up Inflammatory bowel disease AMPK signaling pathway 0 -0.575098814 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Anaerostipes -0.430680786 0 0 butyrate-producing kegg Genus NA 0.568 no no no no no no Inflammatory bowel disease Asthma 0.87826087 0.875494071 0.958301158 kegg kegg NA NA no no no no no no Inflammatory bowel disease Bacterial invasion of epithelial cells 0 0.440711462 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease beta-Alanine metabolism 0 0.440711462 0.59021879 kegg kegg NA NA no no no no no no Inflammatory bowel disease Biosynthesis of unsaturated fatty acids 0 0 0.461518662 kegg kegg NA NA no no no no no no Inflammatory bowel disease cAMP signaling pathway 0 0 -0.492406692 yes kegg kegg NA NA no no no no up up Inflammatory bowel disease Carbon metabolism 0 0.666007905 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Cell adhesion molecules 0 0.433794466 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Chagas disease 0 0 -0.417245817 kegg kegg NA NA no no no no no no Inflammatory bowel disease Cholesterol metabolism 0 0.552371542 0 yes kegg kegg NA NA no no no no no up Inflammatory bowel disease Clostridium 0 0.58071912 0 kegg Genus NA 0.925 no no no no no no Inflammatory bowel disease Cocaine addiction 0 -0.519762846 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Cortisol synthesis and secretion 0 -0.504940711 0 kegg kegg NA NA no no no no no up Inflammatory bowel disease Cushing syndrome 0 -0.504940711 0 kegg kegg NA NA no no no no no up Inflammatory bowel disease Drug metabolism - cytochrome P450 0 0 0.505276705 kegg kegg NA NA no no no no no no Inflammatory bowel disease Endocrine and other factor-regulated calcium reabsorption 0 -0.471343874 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Fatty acid elongation 0 0.421936759 0.476962677 kegg kegg NA NA no no no no no no Inflammatory bowel disease Folate biosynthesis -0.41826087 0 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Galactose metabolism 0 0 0.418275418 kegg kegg NA NA no no no no no no Inflammatory bowel disease Gap junction 0 -0.529644269 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Glucagon signaling pathway 0 -0.420948617 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Glutamatergic synapse 0 -0.539525692 0 kegg kegg NA NA no no no no up up Inflammatory bowel disease Glycolysis / Gluconeogenesis 0 0 0.522265122 kegg kegg NA NA no no no no no no Inflammatory bowel disease Glycosaminoglycan degradation 0 0.42687747 0 kegg kegg NA NA no no no no no up Inflammatory bowel disease Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 -0.415958816 kegg kegg NA NA no no no no no no Inflammatory bowel disease GnRH signaling pathway 0 -0.429841897 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Hematopoietic cell lineage 0.723478261 0.770750988 0.838352638 kegg kegg NA NA no no no no no no Inflammatory bowel disease Histidine metabolism 0 0 0.408751609 kegg kegg NA NA no no no no no no Inflammatory bowel disease Influenza A 0 0.566205534 0.475418275 kegg kegg NA NA no no no no no no Inflammatory bowel disease Insulin secretion 0 -0.507905138 0 yes kegg kegg NA NA no no no no up up Inflammatory bowel disease Intestinal immune network for IgA production 0.754782609 0.701581028 0.826769627 kegg kegg NA NA no no no no no no Inflammatory bowel disease Lachnospira -0.409565217 0 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Inflammatory bowel disease Long-term depression 0 -0.442687747 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Longevity regulating pathway 0 -0.581027668 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Lysosome 0 0.536561265 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Malaria 0 -0.62944664 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Maturity onset diabetes of the young 0.547826087 0 0 kegg kegg NA NA no no no no up no Inflammatory bowel disease Measles -0.452173913 0 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Metabolism of xenobiotics by cytochrome P450 0 0 0.465894466 kegg kegg NA NA no no no no no no Inflammatory bowel disease Mitophagy - animal 0 -0.433794466 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Neuroactive ligand-receptor interaction 0 0.445652174 0 kegg kegg NA NA no no no up up up Inflammatory bowel disease Odoribacter 0.444275267 0 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Inflammatory bowel disease Ovarian steroidogenesis 0 -0.558300395 0 kegg kegg NA NA no no no no up up Inflammatory bowel disease p53 signaling pathway 0 -0.462450593 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Phagosome 0 0.461462451 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Phospholipase D signaling pathway 0 0 -0.408494208 kegg kegg NA NA no no no no up up Inflammatory bowel disease PI3K-Akt signaling pathway -0.420869565 0 0 yes kegg kegg NA NA no no no no up up Inflammatory bowel disease Primary bile acid biosynthesis 0 0 0.426512227 kegg kegg NA NA no no no no no no Inflammatory bowel disease Protein digestion and absorption 0.556521739 0.4743083 0 yes kegg kegg NA NA no no no no up up Inflammatory bowel disease Purine metabolism 0 -0.461462451 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Regulation of lipolysis in adipocytes 0 -0.526679842 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Renin-angiotensin system 0 0.442687747 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Salmonella infection 0 0.468379447 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Shigellosis 0 -0.418972332 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Small cell lung cancer 0 0 -0.414929215 kegg kegg NA NA no no no no no up Inflammatory bowel disease Sphingolipid metabolism 0 0.484189723 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Staphylococcus aureus infection 0 0.640316206 0.473616474 kegg kegg NA NA no no no up no no Inflammatory bowel disease T cell receptor signaling pathway -0.47826087 0 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Taste transduction -0.470434783 0 0 kegg kegg NA NA no no no no no up Inflammatory bowel disease Th1 and Th2 cell differentiation 0.565217391 0.538537549 0.726640927 kegg kegg NA NA no no no no no no Inflammatory bowel disease Th17 cell differentiation 0.585217391 0.449604743 0.764993565 kegg kegg NA NA no no no no no no Inflammatory bowel disease Thiamine metabolism -0.413043478 0 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Thyroid cancer -0.513913043 0 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Thyroid hormone synthesis 0 -0.517786561 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Toxoplasmosis 0.620869565 0.663043478 0.847104247 kegg kegg NA NA no no no no no no Inflammatory bowel disease Tryptophan metabolism 0 0.424901186 0 kegg kegg NA NA no no no no up no Inflammatory bowel disease Tuberculosis 0.500869565 0.585968379 0.504247104 kegg kegg NA NA no no no no no dn Inflammatory bowel disease Type I diabetes mellitus 0 0.421936759 0 kegg kegg NA NA no no no no no no Inflammatory bowel disease Ubiquitin mediated proteolysis 0 -0.436758893 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels ABC transporters -0.693913043 0 0 kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels Adherens junction 0 0.539525692 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Adrenergic signaling in cardiomyocytes 0.890434783 0.793478261 0.867953668 kegg kegg NA NA no no no no no up Inflammatory mediator regulation of TRP channels "Alanine, aspartate and glutamate metabolism" -0.552173913 -0.768774704 -0.42033462 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels alpha-Linolenic acid metabolism -0.709565217 -0.649209486 -0.58970399 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Amino sugar and nucleotide sugar metabolism -0.610434783 0 -0.467181467 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels AMPK signaling pathway 0 0.471343874 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Apelin signaling pathway 0 0.658102767 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Apoptosis -0.612173913 -0.668972332 -0.455083655 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Arginine and proline metabolism -0.674782609 -0.799407115 -0.476447876 kegg kegg NA NA no no no no up no Inflammatory mediator regulation of TRP channels Arginine biosynthesis -0.582608696 -0.721343874 -0.436550837 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Autophagy - animal 0 -0.672924901 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels B cell receptor signaling pathway 0 -0.725296443 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Basal transcription factors 0 0.482213439 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels beta-Alanine metabolism -0.53826087 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Biosynthesis of amino acids -0.569565217 -0.750988142 -0.60978121 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Biosynthesis of cofactors 0 0.470355731 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Butyricimonas 0.460855682 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Inflammatory mediator regulation of TRP channels C-type lectin receptor signaling pathway 0 -0.7243083 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Calcium signaling pathway 0.825217391 0.719367589 0.747747748 kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels cAMP signaling pathway 0.582608696 0 0.441698842 yes kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels Carbon metabolism -0.466956522 0 -0.644787645 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Cardiac muscle contraction 0.520869565 0.790513834 0 kegg kegg NA NA no no no no no up Inflammatory mediator regulation of TRP channels Cell adhesion molecules 0 -0.549407115 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Cell cycle 0 0.558300395 0.497039897 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Cellular senescence 0 -0.473320158 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels cGMP-PKG signaling pathway 0 -0.695652174 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Chemokine signaling pathway 0 -0.56027668 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Circadian entrainment 0.65826087 0.753952569 0.684684685 kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels Circadian rhythm 0.513913043 0.449604743 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Collinsella 0 -0.502230366 0 kegg Genus NA 0.128 no no no no no no Inflammatory mediator regulation of TRP channels Complement and coagulation cascades -0.500869565 -0.660079051 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Cysteine and methionine metabolism 0 0.473320158 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels DNA replication 0 0.511857708 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Dopaminergic synapse 0.772173913 0.780632411 0.836550837 kegg kegg NA NA no no no no up no Inflammatory mediator regulation of TRP channels Drug metabolism - cytochrome P450 0 0.476284585 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Drug metabolism - other enzymes -0.431304348 0.479249012 -0.615186615 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels ECM-receptor interaction 0 0 0.485456885 kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels EGFR tyrosine kinase inhibitor resistance 0 0.577075099 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Endocrine resistance 0.760869565 0.510869565 0.743629344 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Endocytosis 0 -0.51284585 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Ether lipid metabolism 0.406086957 0.518774704 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Fatty acid biosynthesis -0.444347826 -0.747035573 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Fatty acid degradation -0.597391304 -0.693675889 -0.577091377 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Fatty acid metabolism -0.667826087 -0.665019763 -0.471042471 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Fc epsilon RI signaling pathway 0 -0.709486166 -0.435006435 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Fc gamma R-mediated phagocytosis -0.523478261 -0.658102767 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Focal adhesion 0 0.457509881 0 kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels FoxO signaling pathway 0 -0.457509881 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Fructose and mannose metabolism -0.729565217 -0.490118577 -0.717117117 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels GABAergic synapse 0 -0.559288538 0 kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels Galactose metabolism -0.776521739 -0.638339921 -0.597168597 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Gap junction 0.659130435 0 0.494208494 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Glutamatergic synapse 0.570434783 0 0 kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels Glutathione metabolism 0 0.628458498 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Glycerolipid metabolism -0.613043478 0 0 kegg kegg NA NA no no no no no up Inflammatory mediator regulation of TRP channels "Glycine, serine and threonine metabolism" 0 0.440711462 0 kegg kegg NA NA no no no no up no Inflammatory mediator regulation of TRP channels Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.420869565 -0.579051383 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Glycosaminoglycan biosynthesis - keratan sulfate 0.572173913 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Glycosaminoglycan degradation 0 -0.494071146 -0.486743887 kegg kegg NA NA no no no no no up Inflammatory mediator regulation of TRP channels Glyoxylate and dicarboxylate metabolism -0.689565217 -0.755928854 -0.54002574 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Hedgehog signaling pathway 0.506086957 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels HIF-1 signaling pathway 0 0.467391304 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Hippo signaling pathway 0 0.614624506 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Hippo signaling pathway - multiple species 0 -0.692687747 -0.423166023 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Histidine metabolism -0.62 0 -0.52046332 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels IL-17 signaling pathway 0 -0.64229249 -0.564993565 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels JAK-STAT signaling pathway -0.423478261 -0.590909091 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Long-term depression 0.748695652 0 0.657400257 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Long-term potentiation 0.590434783 0 0 kegg kegg NA NA no no no no no up Inflammatory mediator regulation of TRP channels Lysosome 0 -0.53458498 -0.693178893 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels MAPK signaling pathway 0 -0.501976285 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Metabolism of xenobiotics by cytochrome P450 0 0.429841897 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Mitophagy - animal 0.546956522 0.608695652 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels mRNA surveillance pathway 0.475652174 0.673913043 0.43963964 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels mTOR signaling pathway 0 0.548418972 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels N-Glycan biosynthesis 0 0.681818182 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Natural killer cell mediated cytotoxicity 0 -0.449604743 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Necroptosis 0.506956522 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Neuroactive ligand-receptor interaction 0 -0.554347826 -0.49034749 kegg kegg NA NA no no no up up up Inflammatory mediator regulation of TRP channels Neurotrophin signaling pathway 0 -0.58201581 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Neutrophil extracellular trap formation -0.552173913 -0.580039526 -0.445302445 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels NF-kappa B signaling pathway -0.53826087 -0.71541502 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Nicotinate and nicotinamide metabolism -0.537391304 -0.699604743 -0.595366795 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Nitrogen metabolism -0.506956522 -0.663043478 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels NOD-like receptor signaling pathway -0.608695652 -0.807312253 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Nucleotide excision repair 0 0.46541502 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Olfactory transduction 0 -0.572134387 -0.58018018 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels One carbon pool by folate 0 0.540513834 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Oocyte meiosis 0.517391304 0.419960474 0.545173745 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Oscillospira 0 -0.424901186 0 LPS-producing kegg Genus NA 0.62 no no no no no no Inflammatory mediator regulation of TRP channels Osteoclast differentiation -0.67826087 -0.754940711 -0.490862291 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Other glycan degradation -0.74 -0.450592885 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Oxidative phosphorylation 0.509565217 0.801383399 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Pantothenate and CoA biosynthesis -0.413043478 -0.694664032 -0.659459459 kegg kegg NA NA no no no no no dn Inflammatory mediator regulation of TRP channels Paraprevotella 0 0.416075454 0 kegg Genus NA 0.118 no no no no no no Inflammatory mediator regulation of TRP channels Pentose and glucuronate interconversions 0 0.527667984 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Pentose phosphate pathway -0.56173913 -0.619565217 -0.675160875 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Peroxisome -0.579130435 -0.751976285 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Phagosome 0 -0.530632411 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Phosphatidylinositol signaling system 0.587826087 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Phospholipase D signaling pathway 0 -0.414031621 0 kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels Phototransduction 0.577391304 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Platelet activation 0 0.504940711 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels PPAR signaling pathway -0.413043478 -0.817193676 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Prevotella 0 0 0.532951768 acetate-producing kegg Genus NA 0.287 no no no no no no Inflammatory mediator regulation of TRP channels Propanoate metabolism 0 0.416996047 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Proteasome 0 0 -0.500643501 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Protein export 0.51826087 0.648221344 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Protein processing in endoplasmic reticulum 0.448695652 0.625494071 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Purine metabolism 0 0.449604743 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Pyrimidine metabolism -0.545217391 0.470355731 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Pyruvate metabolism 0 0.537549407 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Ras signaling pathway 0.464347826 0.59486166 0 yes kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels Renin-angiotensin system 0 -0.574110672 -0.491891892 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Retrograde endocannabinoid signaling 0 0.746047431 0 kegg kegg NA NA no no no no no up Inflammatory mediator regulation of TRP channels Ribosome 0.52173913 0.70256917 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Ribosome biogenesis in eukaryotes 0 0.485177866 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels RIG-I-like receptor signaling pathway 0 -0.730237154 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels RNA degradation 0.502608696 0.698616601 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels RNA polymerase 0 0.649209486 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Sarcina 0 -0.422326513 0 kegg Genus NA 0.0703 no no no no no no Inflammatory mediator regulation of TRP channels SNARE interactions in vesicular transport -0.673043478 -0.640316206 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Sphingolipid metabolism 0 0 -0.545688546 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Sphingolipid signaling pathway 0 -0.424901186 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Spliceosome 0 0 0.417503218 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Starch and sucrose metabolism -0.808695652 -0.753952569 -0.773745174 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Steroid biosynthesis 0.540869565 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Synaptic vesicle cycle 0 -0.610671937 -0.743371943 kegg kegg NA NA no no no no up up Inflammatory mediator regulation of TRP channels T cell receptor signaling pathway 0 -0.559288538 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Taste transduction 0 0.437747036 0 kegg kegg NA NA no no no no no up Inflammatory mediator regulation of TRP channels TGF-beta signaling pathway 0.507826087 0.673913043 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Th1 and Th2 cell differentiation 0 -0.504940711 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Th17 cell differentiation 0 -0.548418972 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Thermogenesis 0.551304348 0.826086957 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Thiamine metabolism -0.473043478 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels TNF signaling pathway 0 -0.62944664 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Toll-like receptor signaling pathway 0 -0.758893281 0 yes kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Tryptophan metabolism -0.419130435 0 0 kegg kegg NA NA no no no no up no Inflammatory mediator regulation of TRP channels Tyrosine metabolism 0 0.450592885 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Ubiquinone and other terpenoid-quinone biosynthesis -0.426956522 0 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Ubiquitin mediated proteolysis 0.591304348 0.675889328 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Various types of N-glycan biosynthesis 0 0.493083004 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Vascular smooth muscle contraction 0.752173913 0.813241107 0.607207207 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels VEGF signaling pathway 0 -0.434782609 0 kegg kegg NA NA no no no no no no Inflammatory mediator regulation of TRP channels Wnt signaling pathway 0.49826087 0.721343874 0 kegg kegg NA NA no no no no no no Influenza A Adherens junction 0.557391304 0 0.665122265 kegg kegg NA NA no no no no no no Influenza A Aldosterone synthesis and secretion 0 -0.437747036 0 kegg kegg NA NA no no no no up up Influenza A Alistipes 0 -0.462606669 0 kegg Genus NA 0.0114 no no no no up no Influenza A Amphetamine addiction 0 -0.510869565 0 kegg kegg NA NA no no no no no no Influenza A AMPK signaling pathway 0 -0.608695652 0 kegg kegg NA NA no no no no no no Influenza A Apelin signaling pathway -0.704347826 0 0 kegg kegg NA NA no no no no no no Influenza A Apoptosis 0.654782609 0.561264822 0.701158301 kegg kegg NA NA no no no no no no Influenza A Apoptosis - multiple species 0 -0.492094862 -0.503474903 kegg kegg NA NA no no no no no no Influenza A Autophagy - other -0.563478261 0 -0.532046332 kegg kegg NA NA no no no no no no Influenza A Bacterial invasion of epithelial cells 0.587826087 0.51284585 0.63989704 kegg kegg NA NA no no no no no no Influenza A Basal transcription factors -0.539130435 -0.701581028 -0.607464607 kegg kegg NA NA no no no no no no Influenza A Base excision repair -0.486956522 -0.618577075 -0.493693694 kegg kegg NA NA no no no no no no Influenza A Biosynthesis of amino acids 0 0.414031621 0 kegg kegg NA NA no no no no no no Influenza A Biosynthesis of cofactors 0 -0.651185771 0 kegg kegg NA NA no no no no no no Influenza A Carbon metabolism 0 0.467391304 0 kegg kegg NA NA no no no no no no Influenza A Cell adhesion molecules 0.56 0.7243083 0.576319176 kegg kegg NA NA no no no no no no Influenza A Cell cycle -0.665217391 -0.597826087 0 kegg kegg NA NA no no no no no no Influenza A Cellular senescence 0 0.636363636 0 kegg kegg NA NA no no no no no no Influenza A cGMP-PKG signaling pathway 0 0.462450593 0 kegg kegg NA NA no no no no no no Influenza A Chemokine signaling pathway 0 0.420948617 0.52046332 kegg kegg NA NA no no no no no no Influenza A Cholesterol metabolism 0 0.692687747 0 yes kegg kegg NA NA no no no no no up Influenza A Circadian rhythm -0.527826087 -0.647233202 -0.522265122 kegg kegg NA NA no no no no no no Influenza A Complement and coagulation cascades 0 0.435770751 0.537966538 kegg kegg NA NA no no no no no no Influenza A Coprococcus -0.419130435 0 0 butyrate-producing kegg Genus NA 0.612 no no no no no no Influenza A Cortisol synthesis and secretion 0 -0.486166008 0 kegg kegg NA NA no no no no no up Influenza A Cushing syndrome 0 -0.593873518 0 kegg kegg NA NA no no no no no up Influenza A Cysteine and methionine metabolism -0.574782609 0 0 kegg kegg NA NA no no no no no no Influenza A Cytokine-cytokine receptor interaction 0 0 0.426512227 kegg kegg NA NA no no no no no no Influenza A DNA replication -0.451304348 0 -0.433204633 kegg kegg NA NA no no no no no no Influenza A EGFR tyrosine kinase inhibitor resistance -0.500869565 0 -0.405920206 kegg kegg NA NA no no no no no no Influenza A Eggerthella 0 -0.490667928 0 kegg Genus NA 0.912 no no no no no no Influenza A Endocrine resistance 0 -0.441699605 0 kegg kegg NA NA no no no no no no Influenza A Endocytosis 0 0.670948617 0.404890605 kegg kegg NA NA no no no no no no Influenza A Epithelial cell signaling in Helicobacter pylori infection 0.426956522 0.443675889 0 kegg kegg NA NA no no no no no no Influenza A Estrogen signaling pathway -0.436521739 -0.427865613 0 kegg kegg NA NA no no no no no no Influenza A Ether lipid metabolism 0 -0.5256917 0 kegg kegg NA NA no no no no no no Influenza A Eubacterium 0 0 -0.430162599 kegg Genus NA 0.0692 no no no no no no Influenza A Fanconi anemia pathway -0.477391304 -0.567193676 -0.477477477 kegg kegg NA NA no no no no no no Influenza A Fc epsilon RI signaling pathway 0.454782609 0 0 kegg kegg NA NA no no no no no no Influenza A Fc gamma R-mediated phagocytosis 0 0.438735178 0 kegg kegg NA NA no no no no no no Influenza A Focal adhesion 0.525217391 0 0.57992278 kegg kegg NA NA no no no no up up Influenza A Galactose metabolism 0.435652174 0 0 kegg kegg NA NA no no no no no no Influenza A Gastric acid secretion 0 0 0.608494208 kegg kegg NA NA no no no no no no Influenza A Glucagon signaling pathway -0.617391304 -0.473320158 -0.527670528 kegg kegg NA NA no no no no no no Influenza A Glycerophospholipid metabolism 0 -0.488142292 0 kegg kegg NA NA no no no no no up Influenza A "Glycine, serine and threonine metabolism" 0 -0.576086957 0 kegg kegg NA NA no no no no up no Influenza A Glycosaminoglycan degradation 0.417391304 0.537549407 0 kegg kegg NA NA no no no no no up Influenza A Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.559130435 -0.537549407 0 kegg kegg NA NA no no no no no no Influenza A Hedgehog signaling pathway 0 -0.510869565 0 kegg kegg NA NA no no no no no no Influenza A Hematopoietic cell lineage 0 0 0.462805663 kegg kegg NA NA no no no no no no Influenza A HIF-1 signaling pathway -0.573913043 0 0 kegg kegg NA NA no no no no no no Influenza A Hippo signaling pathway 0.472173913 0 0.555212355 kegg kegg NA NA no no no no no no Influenza A Homologous recombination -0.449565217 -0.477272727 -0.502702703 kegg kegg NA NA no no no no no no Influenza A IL-17 signaling pathway 0 0.522727273 0 kegg kegg NA NA no no no no no no Influenza A Inositol phosphate metabolism 0 -0.442687747 0 kegg kegg NA NA no no no no no no Influenza A Insulin secretion 0 -0.435770751 0 yes kegg kegg NA NA no no no no up up Influenza A Insulin signaling pathway -0.683478261 0 0 kegg kegg NA NA no no no no no no Influenza A Intestinal immune network for IgA production 0 0.527667984 0 kegg kegg NA NA no no no no no no Influenza A Leukocyte transendothelial migration 0.584347826 0.506916996 0.664864865 kegg kegg NA NA no no no no no no Influenza A Long-term potentiation -0.58 0 0 kegg kegg NA NA no no no no no up Influenza A Longevity regulating pathway 0 -0.457509881 0 kegg kegg NA NA no no no no no no Influenza A Longevity regulating pathway - multiple species -0.440869565 0 0 kegg kegg NA NA no no no no no no Influenza A Lysine degradation 0 -0.435770751 -0.402059202 kegg kegg NA NA no no no no no no Influenza A Lysosome 0.50173913 0.666996047 0.412355212 kegg kegg NA NA no no no no no no Influenza A Mismatch repair 0 -0.46541502 0 kegg kegg NA NA no no no no no no Influenza A mRNA surveillance pathway 0 0 -0.49034749 kegg kegg NA NA no no no no no no Influenza A mTOR signaling pathway -0.575652174 0 -0.453024453 kegg kegg NA NA no no no no no no Influenza A Mucin type O-glycan biosynthesis -0.456521739 -0.458498024 -0.473873874 kegg kegg NA NA no no no no no no Influenza A N-Glycan biosynthesis -0.587826087 0 0 kegg kegg NA NA no no no no no no Influenza A Natural killer cell mediated cytotoxicity 0.41826087 0.647233202 0 kegg kegg NA NA no no no no no no Influenza A Neuroactive ligand-receptor interaction 0 0.475296443 0 kegg kegg NA NA no no no up up up Influenza A Neutrophil extracellular trap formation 0.520869565 0.56027668 0.571171171 kegg kegg NA NA no no no no no no Influenza A Nicotine addiction 0.472173913 0 0 kegg kegg NA NA no no no no up up Influenza A Nucleotide excision repair -0.457391304 -0.559288538 -0.435006435 kegg kegg NA NA no no no no no no Influenza A One carbon pool by folate -0.428695652 -0.437747036 0 kegg kegg NA NA no no no no no no Influenza A Oocyte meiosis -0.593043478 0 0 kegg kegg NA NA no no no no no no Influenza A Other types of O-glycan biosynthesis -0.553043478 -0.554347826 -0.474646075 kegg kegg NA NA no no no no no no Influenza A Oxytocin signaling pathway 0.444347826 0.490118577 0.492921493 kegg kegg NA NA no no no no no no Influenza A p53 signaling pathway -0.533043478 -0.530632411 -0.61956242 kegg kegg NA NA no no no no no no Influenza A "Parathyroid hormone synthesis, secretion and action" -0.446956522 0 0 kegg kegg NA NA no no no no no no Influenza A Pathogenic Escherichia coli infection 0.613913043 0.678853755 0.70965251 kegg kegg NA NA no no no no no no Influenza A Pentose phosphate pathway 0.506956522 0.586956522 0 kegg kegg NA NA no no no no no no Influenza A Pertussis 0.463478261 0.501976285 0.481081081 kegg kegg NA NA no no no no no dn Influenza A Phagosome 0.646086957 0.749011858 0.693178893 kegg kegg NA NA no no no no no no Influenza A Phosphatidylinositol signaling system 0 -0.563241107 -0.403603604 kegg kegg NA NA no no no no no no Influenza A Phospholipase D signaling pathway 0.446086957 0 0 kegg kegg NA NA no no no no up up Influenza A PI3K-Akt signaling pathway -0.623478261 0 -0.407464607 yes kegg kegg NA NA no no no no up up Influenza A Platelet activation 0.45826087 0 0.634491634 kegg kegg NA NA no no no no no no Influenza A Platinum drug resistance -0.41826087 -0.47826087 -0.484427284 kegg kegg NA NA no no no no no no Influenza A Porphyrin and chlorophyll metabolism 0 -0.5256917 0 kegg kegg NA NA no no no no no no Influenza A Progesterone-mediated oocyte maturation -0.50173913 -0.531620553 0 kegg kegg NA NA no no no no no no Influenza A Propanoate metabolism -0.48 0 0 kegg kegg NA NA no no no no no no Influenza A Protein export -0.648695652 0 0 kegg kegg NA NA no no no no no no Influenza A Protein processing in endoplasmic reticulum -0.600869565 -0.434782609 -0.401029601 kegg kegg NA NA no no no no no no Influenza A Proximal tubule bicarbonate reclamation -0.453913043 0 0 kegg kegg NA NA no no no no no no Influenza A Purine metabolism 0 -0.602766798 0 kegg kegg NA NA no no no no no no Influenza A Pyruvate metabolism -0.412173913 0 0 kegg kegg NA NA no no no no no no Influenza A Rap1 signaling pathway 0.491304348 0.499011858 0.646846847 kegg kegg NA NA no no no no no no Influenza A Renin-angiotensin system 0 0.5256917 0 kegg kegg NA NA no no no no no no Influenza A Retinol metabolism 0 -0.416007905 0 kegg kegg NA NA no no no no no no Influenza A Ribosome -0.444347826 0 0 kegg kegg NA NA no no no no no no Influenza A Ribosome biogenesis in eukaryotes -0.573913043 -0.533596838 -0.457142857 kegg kegg NA NA no no no no no no Influenza A RNA polymerase -0.653043478 -0.513833992 -0.433719434 kegg kegg NA NA no no no no no no Influenza A RNA transport -0.502608696 0 0 kegg kegg NA NA no no no no no no Influenza A Salmonella infection 0 0.64229249 0.587902188 kegg kegg NA NA no no no no no no Influenza A Selenocompound metabolism -0.500869565 -0.68083004 -0.439382239 kegg kegg NA NA no no no no no no Influenza A Sphingolipid metabolism 0.516521739 0.47826087 0 kegg kegg NA NA no no no no no no Influenza A Sphingolipid signaling pathway 0 0.460474308 0 kegg kegg NA NA no no no no no no Influenza A Spinocerebellar ataxia -0.554782609 0 0 kegg kegg NA NA no no no no no no Influenza A Spliceosome -0.594782609 -0.486166008 -0.518146718 kegg kegg NA NA no no no no no no Influenza A Staphylococcus aureus infection 0.736521739 0.718379447 0.584555985 kegg kegg NA NA no no no up no no Influenza A Steroid biosynthesis -0.544347826 0 0 kegg kegg NA NA no no no no no no Influenza A Synaptic vesicle cycle 0 0.414031621 0 kegg kegg NA NA no no no no up up Influenza A Synthesis and degradation of ketone bodies -0.406956522 -0.56027668 0 kegg kegg NA NA no no no no no no Influenza A Taste transduction -0.591304348 -0.536561265 0 kegg kegg NA NA no no no no no up Influenza A Terpenoid backbone biosynthesis -0.587826087 -0.492094862 -0.444015444 kegg kegg NA NA no no no no no no Influenza A Th1 and Th2 cell differentiation 0.495652174 0.593873518 0 kegg kegg NA NA no no no no no no Influenza A Th17 cell differentiation 0.456521739 0.491106719 0 kegg kegg NA NA no no no no no no Influenza A Thyroid hormone signaling pathway 0.583478261 0 0.593050193 kegg kegg NA NA no no no no no no Influenza A Tight junction 0.434782609 0 0.507593308 kegg kegg NA NA no no no no no no Influenza A Toxoplasmosis 0.452173913 0.507905138 0.457400257 kegg kegg NA NA no no no no no no Influenza A Tuberculosis 0.719130435 0.658102767 0.564478764 kegg kegg NA NA no no no no no dn Influenza A Type I diabetes mellitus 0.605217391 0.765810277 0.535135135 kegg kegg NA NA no no no no no no Influenza A Ubiquinone and other terpenoid-quinone biosynthesis 0 0 -0.423938224 kegg kegg NA NA no no no no no no Influenza A Various types of N-glycan biosynthesis -0.683478261 0 0 kegg kegg NA NA no no no no no no Influenza A Vibrio cholerae infection 0.471304348 0 0.673101673 kegg kegg NA NA no no no no no no Influenza A Yersinia infection 0.576521739 0.730237154 0.753410553 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Amino sugar and nucleotide sugar metabolism 0 0.530632411 0.492664093 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Arginine biosynthesis 0 0 -0.4002574 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Ascorbate and aldarate metabolism 0 0 0.633976834 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Citrate cycle (TCA cycle) 0 0 0.415444015 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Fatty acid degradation 0 0.475296443 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Fructose and mannose metabolism 0 0.599802372 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Galactose metabolism 0.446956522 0.505928854 0.464864865 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Glutathione metabolism -0.468695652 0 -0.477992278 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Glycerolipid metabolism 0.666956522 0.846837945 0.807979408 kegg kegg NA NA no no no no no up Inositol phosphate metabolism Glycolysis / Gluconeogenesis 0 -0.500988142 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.575098814 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.610810811 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Glycosaminoglycan degradation 0 0 0.437065637 kegg kegg NA NA no no no no no up Inositol phosphate metabolism Histidine metabolism 0.446956522 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Lysine degradation 0.424347826 0.753952569 0.788416988 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Mannose type O-glycan biosynthesis 0 0.597826087 0.737194337 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Mucin type O-glycan biosynthesis 0 0.613636364 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism N-Glycan biosynthesis 0 0 0.589189189 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Other glycan degradation 0 0.758893281 0.726640927 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Other types of O-glycan biosynthesis 0 0.767786561 0.860746461 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Oxidative phosphorylation 0 -0.490118577 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Selenocompound metabolism 0.429565217 0.798418972 0.81981982 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Steroid biosynthesis 0 0 0.511969112 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Steroid hormone biosynthesis 0 0 0.523809524 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Synthesis and degradation of ketone bodies 0 0 0.493693694 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Taurine and hypotaurine metabolism 0.489565217 0.748023715 0.55032175 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.440869565 0 0.471299871 kegg kegg NA NA no no no no no no Inositol phosphate metabolism "Valine, leucine and isoleucine degradation" 0.429565217 0 0 kegg kegg NA NA no no no no no no Inositol phosphate metabolism Various types of N-glycan biosynthesis 0 0 0.538223938 kegg kegg NA NA no no no no no no INS0h+clinic 12-ketoDCA+blood 0 -0.525893648 0 clinic serum_bileacids 0.0633 0.517 no up no no no no INS0h+clinic 14:0+blood 0.51496388 0 0 yes clinic serum_fattyacid 0.0633 0.00572 no up no up no dn INS0h+clinic 16:0/20:5-PC+blood 0.60371517 0 0 clinic serum_phospholipids 0.0633 0.628 no up no no no no INS0h+clinic 18:0/20:3-PC+blood 0 0 0.483076923 clinic serum_phospholipids 0.0633 0.0682 no up no no up no INS0h+clinic 18:0/20:3-PI+blood 0 0.571428571 0 clinic serum_phospholipids 0.0633 0.377 no up no no no no INS0h+clinic 18:0/20:4-PI+blood -0.653250774 0 0 clinic serum_phospholipids 0.0633 0.167 no up no no no no INS0h+clinic 18:0/22:6-PC+blood 0.55624355 0 0 clinic serum_phospholipids 0.0633 0.0775 no up no no no up INS0h+clinic 18:1-LPC+blood -0.624355005 0 0 clinic serum_phospholipids 0.0633 0.179 no up no no no no INS0h+clinic 18:2-LPC+blood 0 -0.642857143 0 clinic serum_phospholipids 0.0633 0.00743 no up no dn no up INS0h+clinic 18:2-LPE+blood 0 0 -0.505384615 clinic serum_phospholipids 0.0633 0.112 no up no no no no INS0h+clinic 18:2/18:2-PC+blood 0 -0.578571429 0 clinic serum_phospholipids 0.0633 1.98E-05 no up no dn up up INS0h+clinic 18:3n3+blood 0 0 -0.411538462 clinic serum_fattyacid 0.0633 0.291 no up no no no no INS0h+clinic 20:2/18:0-PC+blood 0 0 0.471538462 clinic serum_phospholipids 0.0633 0.0427 no up no no up no INS0h+clinic 20:3n6+blood 0 0.532142857 0.41 clinic serum_fattyacid 0.0633 0.0884 no up no up no no INS0h+clinic 20:5n3+blood 0.618163055 0 0 clinic serum_fattyacid 0.0633 0.988 no up no no no no INS0h+clinic Blautia 0 0.444381705 -0.424185748 acetate-producing clinic Genus 0.0633 1.36E-05 no up no up dn dn INS0h+clinic C-peptide 0.583003953 0.51552795 0 clinic DM-assocaited hormones 0.0633 0.228 no up no no no no INS0h+clinic CA+stool 0 0.618181818 0 clinic stool_bileacids 0.0633 0.827 no up no no no no INS0h+clinic CDCA+stool 0 0.890909091 0 clinic stool_bileacids 0.0633 0.663 no up no no no no INS0h+clinic Collinsella 0.538670637 0 0 clinic Genus 0.0633 0.128 no up no no no no INS0h+clinic Coprococcus 0 0.456804065 0 butyrate-producing clinic Genus 0.0633 0.612 no up no no no no INS0h+clinic Dorea 0 0.565377035 0 clinic Genus 0.0633 0.00362 no up no up no dn INS0h+clinic EPA+blood 0.529411765 0 0 clinic serum_ARA 0.0633 0.212 no up no no no no INS0h+clinic Gap junction 0.4432524 0 0 clinic kegg 0.0633 NA no up no no no no INS0h+clinic GCA+stool 0.582352941 0.627272727 0 clinic stool_bileacids 0.0633 0.0809 no up no no no no INS0h+clinic GCDCA+stool 0.802941176 0.7 0 yes clinic stool_bileacids 0.0633 0.0471 no up no no dn no INS0h+clinic "Glycine, serine and threonine metabolism" 0.424054207 0 0 clinic kegg 0.0633 NA no up no no up no INS0h+clinic HDCA+blood 0 -0.525893648 0 clinic serum_bileacids 0.0633 0.483 no up no no no no INS0h+clinic IP-10 0 0.466666667 0 clinic serum_cytokines 0.0633 0.394 no up no no no no INS0h+clinic iso-LCA+blood 0 -0.567699746 0 clinic serum_bileacids 0.0633 0.507 no up no no no no INS0h+clinic L-Phenylalanine+blood 0 0.6 0 yes clinic serum_aminoacids 0.0633 0.0103 no up no up up no INS0h+clinic L-Proline+blood 0 0.653571429 0 yes clinic serum_aminoacids 0.0633 0.00265 no up no up up no INS0h+clinic L-Tryptophan+blood 0 0.553571429 0 clinic serum_aminoacids 0.0633 0.164 no up no no no no INS0h+clinic L-Tyrosine+blood 0 0.782142857 0 yes clinic serum_aminoacids 0.0633 0.00913 no up no up up no INS0h+clinic Leptin 0.558300395 0.428571429 0.493659282 clinic DM-assocaited hormones 0.0633 0.706 no up no no no no INS0h+clinic n3+blood 0.529411765 0 0 clinic serum_fattyacid 0.0633 0.806 no up no no no no INS0h+clinic n6/n3+blood -0.529411765 0 0 clinic serum_fattyacid 0.0633 0.226 no up no no no no INS0h+clinic Odoribacter -0.428956059 0 0 butyrate-producing clinic Genus 0.0633 0.798 no up no no no no INS0h+clinic Parabacteroides 0 -0.4432524 0 clinic Genus 0.0633 4.19E-05 no up no no up up INS0h+clinic PUFA/MUFA+blood 0.469556244 0 0 clinic serum_fattyacid 0.0633 0.00108 no up no dn no up INS0h+clinic Resistin -0.571146245 0 0 clinic DM-assocaited hormones 0.0633 0.156 no up no no no no INS0h+clinic Roseburia 0 0.570460345 0 butyrate-producing clinic Genus 0.0633 0.495 no up no no no no INS0h+clinic total_stool_scfa+stool 0 -0.627272727 0 clinic stool_scfa 0.0633 0.0534 no up no dn no up INS0h+clinic UDCA+stool 0 0.727272727 0 clinic stool_bileacids 0.0633 0.266 no up no no no no INS0h+clinic Visfatin -0.622529644 0 0 clinic DM-assocaited hormones 0.0633 0.0229 no up no dn no up Insulin C-peptide 0.768774704 0.784347826 0.444257703 yes DM-assocaited hormones DM-assocaited hormones 0.00058 0.228 up up no no no no Insulin Ghrelin 0 -0.559130435 -0.403641457 yes yes DM-assocaited hormones DM-assocaited hormones 0.00058 0.0108 up up no dn no no Insulin GIP 0 -0.536521739 0 yes DM-assocaited hormones DM-assocaited hormones 0.00058 0.374 up up no no no no Insulin resistance 2-Oxocarboxylic acid metabolism -0.585217391 -0.517786561 0 kegg kegg NA NA no no no no no no Insulin resistance ABC transporters 0 0.484189723 0 kegg kegg NA NA no no no no up up Insulin resistance Adherens junction -0.617391304 -0.654150198 -0.54028314 kegg kegg NA NA no no no no no no Insulin resistance Adipocytokine signaling pathway 0 0.694664032 0 kegg kegg NA NA no no no no no no Insulin resistance "Alanine, aspartate and glutamate metabolism" 0 0.628458498 0 kegg kegg NA NA no no no no no no Insulin resistance Amino sugar and nucleotide sugar metabolism -0.419130435 0 0 kegg kegg NA NA no no no no no no Insulin resistance Anaerostipes 0 0 -0.401508502 butyrate-producing kegg Genus NA 0.568 no no no no no no Insulin resistance Apelin signaling pathway 0 -0.687747036 0 kegg kegg NA NA no no no no no no Insulin resistance Apoptosis 0 0.675889328 0 kegg kegg NA NA no no no no no no Insulin resistance Arachidonic acid metabolism -0.502608696 0 -0.467438867 kegg kegg NA NA no no no no no no Insulin resistance Arginine and proline metabolism 0 0.615612648 0 kegg kegg NA NA no no no no up no Insulin resistance Arginine biosynthesis 0 0.566205534 0 kegg kegg NA NA no no no no no no Insulin resistance Autophagy - animal 0.729565217 0.864624506 0 kegg kegg NA NA no no no no no no Insulin resistance Autophagy - other 0.787826087 0.570158103 0.627541828 kegg kegg NA NA no no no no no no Insulin resistance Axon guidance 0.432173913 0 0 kegg kegg NA NA no no no no up up Insulin resistance B cell receptor signaling pathway 0.580869565 0.83201581 0.595366795 kegg kegg NA NA no no no no no no Insulin resistance Basal transcription factors 0.465217391 0 0 kegg kegg NA NA no no no no no no Insulin resistance beta-Alanine metabolism -0.648695652 -0.611660079 -0.625740026 kegg kegg NA NA no no no no no no Insulin resistance Biosynthesis of amino acids -0.551304348 0 -0.46023166 kegg kegg NA NA no no no no no no Insulin resistance Biosynthesis of cofactors -0.465217391 -0.48715415 0 kegg kegg NA NA no no no no no no Insulin resistance Biosynthesis of unsaturated fatty acids -0.454782609 -0.608695652 -0.588416988 kegg kegg NA NA no no no no no no Insulin resistance Butanoate metabolism -0.488695652 -0.755928854 0 kegg kegg NA NA no no no no no no Insulin resistance C-type lectin receptor signaling pathway 0.789565217 0.827075099 0.735649936 kegg kegg NA NA no no no no no no Insulin resistance Calcium signaling pathway 0 0 0.46048906 kegg kegg NA NA no no no no up up Insulin resistance cAMP signaling pathway 0.531304348 0.624505929 0.457142857 yes kegg kegg NA NA no no no no up up Insulin resistance Carbon metabolism -0.675652174 -0.449604743 -0.546718147 kegg kegg NA NA no no no no no no Insulin resistance Cardiac muscle contraction 0 -0.490118577 0 kegg kegg NA NA no no no no no up Insulin resistance Cell adhesion molecules -0.525217391 0 0 kegg kegg NA NA no no no no no no Insulin resistance Cellular senescence 0 0.446640316 0 kegg kegg NA NA no no no no no no Insulin resistance Chemokine signaling pathway 0 0.491106719 0 kegg kegg NA NA no no no no no no Insulin resistance Cholinergic synapse 0.506086957 0 0.453281853 kegg kegg NA NA no no no no no no Insulin resistance Circadian entrainment 0 -0.685770751 0 kegg kegg NA NA no no no no up up Insulin resistance Circadian rhythm 0.7 0 0.647104247 kegg kegg NA NA no no no no no no Insulin resistance Citrate cycle (TCA cycle) -0.489565217 -0.769762846 0 kegg kegg NA NA no no no no no no Insulin resistance Clostridium 0 -0.420766661 0 kegg Genus NA 0.925 no no no no no no Insulin resistance Collinsella 0 0 -0.438165286 kegg Genus NA 0.128 no no no no no no Insulin resistance Complement and coagulation cascades -0.448695652 0 -0.586615187 kegg kegg NA NA no no no no no no Insulin resistance Cysteine and methionine metabolism 0 -0.789525692 0 kegg kegg NA NA no no no no no no Insulin resistance Cytokine-cytokine receptor interaction 0 0 -0.600514801 kegg kegg NA NA no no no no no no Insulin resistance Cytosolic DNA-sensing pathway 0 0.656126482 0 kegg kegg NA NA no no no no no no Insulin resistance DNA replication 0 -0.659090909 0 kegg kegg NA NA no no no no no no Insulin resistance Dopaminergic synapse 0 -0.583992095 0 kegg kegg NA NA no no no no up no Insulin resistance Drug metabolism - cytochrome P450 -0.42173913 -0.7756917 0 kegg kegg NA NA no no no no no no Insulin resistance Drug metabolism - other enzymes -0.679130435 -0.799407115 0 kegg kegg NA NA no no no no no no Insulin resistance ECM-receptor interaction 0 -0.504940711 0 kegg kegg NA NA no no no no up up Insulin resistance EGFR tyrosine kinase inhibitor resistance 0.446086957 -0.517786561 0 kegg kegg NA NA no no no no no no Insulin resistance ErbB signaling pathway 0.646086957 0.717391304 0.54980695 kegg kegg NA NA no no no no no no Insulin resistance Estrogen signaling pathway 0 -0.67687747 -0.477992278 kegg kegg NA NA no no no no no no Insulin resistance Fatty acid biosynthesis 0 0.60770751 0 kegg kegg NA NA no no no no no no Insulin resistance Fatty acid elongation -0.60173913 -0.67687747 -0.582239382 kegg kegg NA NA no no no no no no Insulin resistance Fc epsilon RI signaling pathway 0.435652174 0.748023715 0 kegg kegg NA NA no no no no no no Insulin resistance Fc gamma R-mediated phagocytosis 0 0 -0.406177606 kegg kegg NA NA no no no no no no Insulin resistance Focal adhesion -0.706956522 -0.746047431 -0.599485199 kegg kegg NA NA no no no no up up Insulin resistance FoxO signaling pathway 0 0.613636364 0 kegg kegg NA NA no no no no no no Insulin resistance Fructose and mannose metabolism 0 0.519762846 0 kegg kegg NA NA no no no no no no Insulin resistance Galactose metabolism 0 0.48715415 0 kegg kegg NA NA no no no no no no Insulin resistance Glucagon signaling pathway 0 -0.476284585 0 kegg kegg NA NA no no no no no no Insulin resistance Glutathione metabolism -0.439130435 -0.634387352 -0.454054054 kegg kegg NA NA no no no no no no Insulin resistance Glycerolipid metabolism 0 0.562252964 0.492406692 kegg kegg NA NA no no no no no up Insulin resistance Glycerophospholipid metabolism 0.563478261 0.5 0.479279279 kegg kegg NA NA no no no no no up Insulin resistance "Glycine, serine and threonine metabolism" -0.420869565 0 0 kegg kegg NA NA no no no no up no Insulin resistance Glycolysis / Gluconeogenesis -0.633913043 -0.75 -0.584041184 kegg kegg NA NA no no no no no no Insulin resistance Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.838932806 0 kegg kegg NA NA no no no no no no Insulin resistance Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.65826087 0 0 kegg kegg NA NA no no no no no no Insulin resistance Glycosphingolipid biosynthesis - globo and isoglobo series -0.42173913 0 0 kegg kegg NA NA no no no no no no Insulin resistance Glycosphingolipid biosynthesis - lacto and neolacto series 0.505217391 0.520750988 0.526640927 kegg kegg NA NA no no no no no no Insulin resistance Glyoxylate and dicarboxylate metabolism 0 0.561264822 0 kegg kegg NA NA no no no no no no Insulin resistance GnRH secretion 0.668695652 0.769762846 0.565508366 kegg kegg NA NA no no no no up up Insulin resistance Hedgehog signaling pathway 0 0 0.601287001 kegg kegg NA NA no no no no no no Insulin resistance Hematopoietic cell lineage 0 -0.500988142 -0.463835264 kegg kegg NA NA no no no no no no Insulin resistance HIF-1 signaling pathway 0 -0.60770751 0 kegg kegg NA NA no no no no no no Insulin resistance Hippo signaling pathway -0.673043478 -0.685770751 -0.518661519 kegg kegg NA NA no no no no no no Insulin resistance Hippo signaling pathway - multiple species 0.406086957 0.593873518 0 kegg kegg NA NA no no no no no no Insulin resistance Inflammatory mediator regulation of TRP channels 0 -0.58201581 0 kegg kegg NA NA no no no no no no Insulin resistance Inositol phosphate metabolism 0 0.442687747 0 kegg kegg NA NA no no no no no no Insulin resistance Insulin signaling pathway 0 -0.635375494 0 kegg kegg NA NA no no no no no no Insulin resistance JAK-STAT signaling pathway 0 0.818181818 0 kegg kegg NA NA no no no no no no Insulin resistance Lachnospira 0 -0.50111195 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Insulin resistance Leukocyte transendothelial migration -0.551304348 0 -0.623166023 kegg kegg NA NA no no no no no no Insulin resistance Long-term potentiation 0 -0.611660079 0 kegg kegg NA NA no no no no no up Insulin resistance Longevity regulating pathway - multiple species 0 0 -0.547232947 kegg kegg NA NA no no no no no no Insulin resistance Lysine degradation 0.631304348 0 0.576576577 kegg kegg NA NA no no no no no no Insulin resistance Mannose type O-glycan biosynthesis 0.595652174 0 0.567824968 kegg kegg NA NA no no no no no no Insulin resistance Melanogenesis 0 -0.496047431 0 kegg kegg NA NA no no no no no no Insulin resistance Metabolism of xenobiotics by cytochrome P450 -0.546956522 -0.793478261 -0.435521236 kegg kegg NA NA no no no no no no Insulin resistance Mismatch repair 0 -0.682806324 0 kegg kegg NA NA no no no no no no Insulin resistance mRNA surveillance pathway 0.685217391 0 0.56962677 kegg kegg NA NA no no no no no no Insulin resistance mTOR signaling pathway 0 -0.518774704 0 kegg kegg NA NA no no no no no no Insulin resistance N-Glycan biosynthesis 0 -0.56916996 0 kegg kegg NA NA no no no no no no Insulin resistance Natural killer cell mediated cytotoxicity -0.423478261 0 0 kegg kegg NA NA no no no no no no Insulin resistance Neurotrophin signaling pathway 0.69826087 0.811264822 0.675933076 kegg kegg NA NA no no no no no no Insulin resistance Neutrophil extracellular trap formation 0 0 -0.453539254 kegg kegg NA NA no no no no no no Insulin resistance NF-kappa B signaling pathway 0.590434783 0.920948617 0.788416988 kegg kegg NA NA no no no no no no Insulin resistance Nicotinate and nicotinamide metabolism 0 0.601778656 0 kegg kegg NA NA no no no no no no Insulin resistance Nitrogen metabolism 0 0.553359684 0 kegg kegg NA NA no no no no no no Insulin resistance NOD-like receptor signaling pathway 0 0.7243083 0 kegg kegg NA NA no no no no no no Insulin resistance Non-homologous end-joining -0.606086957 -0.746047431 -0.602574003 kegg kegg NA NA no no no no no no Insulin resistance Notch signaling pathway 0.522608696 0.616600791 0.480823681 kegg kegg NA NA no no no no no no Insulin resistance Nucleotide excision repair 0 -0.62055336 0 kegg kegg NA NA no no no no no no Insulin resistance One carbon pool by folate 0 -0.609683794 0 kegg kegg NA NA no no no no no no Insulin resistance Oocyte meiosis 0 -0.767786561 0 kegg kegg NA NA no no no no no no Insulin resistance Osteoclast differentiation 0 0.603754941 0 kegg kegg NA NA no no no no no no Insulin resistance Other glycan degradation 0 0.568181818 0 kegg kegg NA NA no no no no no no Insulin resistance Other types of O-glycan biosynthesis 0.74173913 0 0.492406692 kegg kegg NA NA no no no no no no Insulin resistance Oxidative phosphorylation 0 -0.546442688 0 kegg kegg NA NA no no no no no no Insulin resistance Oxytocin signaling pathway -0.745217391 -0.5 -0.706306306 kegg kegg NA NA no no no no no no Insulin resistance p53 signaling pathway 0.673043478 0 0 kegg kegg NA NA no no no no no no Insulin resistance Pantothenate and CoA biosynthesis 0 0.420948617 0 kegg kegg NA NA no no no no no dn Insulin resistance Paraprevotella -0.466995794 0 0 kegg Genus NA 0.118 no no no no no no Insulin resistance "Parathyroid hormone synthesis, secretion and action" 0.433043478 0 0 kegg kegg NA NA no no no no no no Insulin resistance Pentose and glucuronate interconversions -0.506956522 -0.679841897 0 kegg kegg NA NA no no no no no no Insulin resistance Peroxisome 0 0.414031621 0 kegg kegg NA NA no no no no no no Insulin resistance Phagosome -0.532173913 0 0 kegg kegg NA NA no no no no no no Insulin resistance Phenylalanine metabolism -0.752173913 -0.706521739 -0.507593308 kegg kegg NA NA no no no no no no Insulin resistance Phosphatidylinositol signaling system 0.468695652 0 0.497039897 kegg kegg NA NA no no no no no no Insulin resistance Phospholipase D signaling pathway 0 0.735177866 0 kegg kegg NA NA no no no no up up Insulin resistance Phototransduction 0 -0.805335968 0 kegg kegg NA NA no no no no no no Insulin resistance PI3K-Akt signaling pathway 0.48173913 0 0 yes kegg kegg NA NA no no no no up up Insulin resistance Platelet activation -0.722608696 -0.634387352 -0.56010296 kegg kegg NA NA no no no no no no Insulin resistance Platinum drug resistance 0.429565217 0 0 kegg kegg NA NA no no no no no no Insulin resistance Porphyrin and chlorophyll metabolism -0.412173913 0 0 kegg kegg NA NA no no no no no no Insulin resistance PPAR signaling pathway 0 0.593873518 0 kegg kegg NA NA no no no no no no Insulin resistance Primary bile acid biosynthesis 0 -0.697628458 -0.614414414 kegg kegg NA NA no no no no no no Insulin resistance Progesterone-mediated oocyte maturation 0.550434783 0 0.451994852 kegg kegg NA NA no no no no no no Insulin resistance Prolactin signaling pathway 0.440869565 0.736166008 0.513770914 kegg kegg NA NA no no no no no no Insulin resistance Propanoate metabolism 0 -0.774703557 0 kegg kegg NA NA no no no no no no Insulin resistance Proteasome 0 -0.733201581 0 kegg kegg NA NA no no no no no no Insulin resistance Protein export 0.420869565 -0.677865613 0 kegg kegg NA NA no no no no no no Insulin resistance Protein processing in endoplasmic reticulum 0 -0.550395257 0 kegg kegg NA NA no no no no no no Insulin resistance Pyramidobacter 0 0 0.410901342 kegg Genus NA 0.45 no no no no no no Insulin resistance Pyrimidine metabolism -0.449565217 -0.635375494 0 kegg kegg NA NA no no no no no no Insulin resistance Pyruvate metabolism 0 -0.787549407 0 kegg kegg NA NA no no no no no no Insulin resistance Rap1 signaling pathway -0.50173913 0 -0.462548263 kegg kegg NA NA no no no no no no Insulin resistance Ras signaling pathway 0 -0.59486166 0 yes kegg kegg NA NA no no no no up up Insulin resistance Regulation of actin cytoskeleton -0.712173913 -0.725296443 -0.700643501 kegg kegg NA NA no no no no no no Insulin resistance Relaxin signaling pathway 0.6 0.750988142 0.452252252 kegg kegg NA NA no no no no no no Insulin resistance Renin secretion -0.5 -0.703557312 0 kegg kegg NA NA no no no no no no Insulin resistance Retinol metabolism -0.502608696 -0.556324111 0 kegg kegg NA NA no no no no no no Insulin resistance Retrograde endocannabinoid signaling 0 -0.654150198 0 kegg kegg NA NA no no no no no up Insulin resistance Ribosome 0.426086957 -0.577075099 0 kegg kegg NA NA no no no no no no Insulin resistance RIG-I-like receptor signaling pathway 0.752173913 0.877470356 0.750579151 kegg kegg NA NA no no no no no no Insulin resistance RNA degradation 0.594782609 -0.424901186 0.531016731 kegg kegg NA NA no no no no no no Insulin resistance RNA polymerase 0.436521739 -0.436758893 0 kegg kegg NA NA no no no no no no Insulin resistance RNA transport 0 -0.462450593 0 kegg kegg NA NA no no no no no no Insulin resistance Roseburia -0.446086957 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no Insulin resistance Sarcina 0 0.422326513 0 kegg Genus NA 0.0703 no no no no no no Insulin resistance Selenocompound metabolism 0.60173913 0 0 kegg kegg NA NA no no no no no no Insulin resistance Signaling pathways regulating pluripotency of stem cells 0.68173913 0.518774704 0.542857143 kegg kegg NA NA no no no no no no Insulin resistance SNARE interactions in vesicular transport 0 0.662055336 0.423680824 kegg kegg NA NA no no no no no no Insulin resistance Sphingolipid signaling pathway 0.431304348 0.428853755 0 kegg kegg NA NA no no no no no no Insulin resistance Spliceosome 0.542608696 0 0.466409266 kegg kegg NA NA no no no no no no Insulin resistance Starch and sucrose metabolism 0 0.532608696 0 kegg kegg NA NA no no no no no no Insulin resistance Steroid biosynthesis 0 -0.720355731 0 kegg kegg NA NA no no no no no no Insulin resistance Steroid hormone biosynthesis -0.513043478 -0.654150198 0 kegg kegg NA NA no no no no no no Insulin resistance Sulfur metabolism -0.559130435 -0.56027668 0 kegg kegg NA NA no no no no no no Insulin resistance Synthesis and degradation of ketone bodies 0 -0.603754941 0 kegg kegg NA NA no no no no no no Insulin resistance T cell receptor signaling pathway 0.584347826 0.657114625 0 kegg kegg NA NA no no no no no no Insulin resistance Taste transduction 0 -0.435770751 0.411325611 kegg kegg NA NA no no no no no up Insulin resistance Taurine and hypotaurine metabolism 0.596521739 0.745059289 0.603861004 kegg kegg NA NA no no no no no no Insulin resistance TGF-beta signaling pathway 0 -0.650197628 0 kegg kegg NA NA no no no no no no Insulin resistance Th1 and Th2 cell differentiation 0 0.481225296 0 kegg kegg NA NA no no no no no no Insulin resistance Th17 cell differentiation 0 0.543478261 0 kegg kegg NA NA no no no no no no Insulin resistance Thermogenesis 0 -0.599802372 0 kegg kegg NA NA no no no no no no Insulin resistance Thiamine metabolism 0 -0.62944664 0 kegg kegg NA NA no no no no no no Insulin resistance Thyroid hormone signaling pathway -0.425217391 -0.468379447 0 kegg kegg NA NA no no no no no no Insulin resistance Tight junction -0.630434783 -0.725296443 -0.747490347 kegg kegg NA NA no no no no no no Insulin resistance TNF signaling pathway 0.766086957 0.927865613 0.61003861 kegg kegg NA NA no no no no no no Insulin resistance Toll-like receptor signaling pathway 0.539130435 0.7756917 0 yes kegg kegg NA NA no no no no no no Insulin resistance Tryptophan metabolism -0.537391304 -0.73715415 0 kegg kegg NA NA no no no no up no Insulin resistance Type II diabetes mellitus 0.731304348 0.836956522 0.562419562 kegg kegg NA NA no no no no no no Insulin resistance Tyrosine metabolism -0.72 -0.791501976 -0.722265122 kegg kegg NA NA no no no no no no Insulin resistance Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.624505929 0 kegg kegg NA NA no no no no no no Insulin resistance "Valine, leucine and isoleucine degradation" 0 -0.70256917 0 kegg kegg NA NA no no no no no no Insulin resistance Various types of N-glycan biosynthesis 0 -0.444664032 0 kegg kegg NA NA no no no no no no Insulin resistance Vascular smooth muscle contraction 0 -0.650197628 0 kegg kegg NA NA no no no no no no Insulin resistance VEGF signaling pathway 0.56173913 0.599802372 0.407464607 kegg kegg NA NA no no no no no no Insulin resistance Viral protein interaction with cytokine and cytokine receptor 0 0 -0.541570142 kegg kegg NA NA no no no no no no Insulin resistance Wnt signaling pathway 0 -0.421936759 0.502960103 kegg kegg NA NA no no no no no no Insulin secretion 2-Oxocarboxylic acid metabolism 0 0 -0.484169884 yes kegg kegg NA NA no up up no no no Insulin secretion Adrenergic signaling in cardiomyocytes 0.51826087 0.750988142 0.737709138 yes kegg kegg NA NA no up up no no up Insulin secretion "Alanine, aspartate and glutamate metabolism" -0.448695652 0 0 yes kegg kegg NA NA no up up no no no Insulin secretion alpha-Linolenic acid metabolism -0.533913043 0 -0.685971686 yes kegg kegg NA NA no up up no no no Insulin secretion Amino sugar and nucleotide sugar metabolism -0.456521739 0 -0.523294723 yes kegg kegg NA NA no up up no no no Insulin secretion AMPK signaling pathway 0.564347826 0.658102767 0 yes kegg kegg NA NA no up up no no no Insulin secretion Antigen processing and presentation -0.58173913 -0.472332016 0 yes kegg kegg NA NA no up up no no no Insulin secretion Arginine and proline metabolism -0.685217391 0 0 yes kegg kegg NA NA no up up no up no Insulin secretion Arginine biosynthesis -0.485217391 0 0 yes kegg kegg NA NA no up up no no no Insulin secretion Ascorbate and aldarate metabolism 0 0 -0.581724582 yes kegg kegg NA NA no up up no no no Insulin secretion beta-Alanine metabolism 0 -0.43083004 -0.642213642 yes kegg kegg NA NA no up up no no no Insulin secretion Biosynthesis of amino acids -0.492173913 -0.739130435 -0.447876448 yes kegg kegg NA NA no up up no no no Insulin secretion Biosynthesis of cofactors 0 0.438735178 0 yes kegg kegg NA NA no up up no no no Insulin secretion Biosynthesis of unsaturated fatty acids 0 -0.416996047 -0.467438867 yes kegg kegg NA NA no up up no no no Insulin secretion Butanoate metabolism 0 0 -0.433462033 yes kegg kegg NA NA no up up no no no Insulin secretion Calcium signaling pathway 0.575652174 0.756916996 0.844272844 yes kegg kegg NA NA no up up no up up Insulin secretion cAMP signaling pathway 0 0 0.75006435 yes yes kegg kegg NA NA no up up no up up Insulin secretion Carbon metabolism -0.415652174 -0.756916996 -0.61956242 yes kegg kegg NA NA no up up no no no Insulin secretion Cardiac muscle contraction 0 0.529644269 0 yes kegg kegg NA NA no up up no no up Insulin secretion Cell adhesion molecules 0 -0.688735178 0 yes kegg kegg NA NA no up up no no no Insulin secretion Cell cycle 0 0.437747036 0 yes kegg kegg NA NA no up up no no no Insulin secretion Cellular senescence 0 -0.448616601 0 yes kegg kegg NA NA no up up no no no Insulin secretion cGMP-PKG signaling pathway 0 -0.616600791 0 yes kegg kegg NA NA no up up no no no Insulin secretion Circadian entrainment 0.424347826 0 0.64015444 yes kegg kegg NA NA no up up no up up Insulin secretion Circadian rhythm 0 0.599802372 0 yes kegg kegg NA NA no up up no no no Insulin secretion Citrate cycle (TCA cycle) 0 0 -0.56010296 yes kegg kegg NA NA no up up no no no Insulin secretion Clostridium 0 -0.493101849 0 yes kegg Genus NA 0.925 no up up no no no Insulin secretion Complement and coagulation cascades -0.426956522 -0.632411067 0 yes kegg kegg NA NA no up up no no no Insulin secretion Cytokine-cytokine receptor interaction 0 -0.484189723 0 yes kegg kegg NA NA no up up no no no Insulin secretion Dopaminergic synapse 0.494782609 0.604743083 0.763963964 yes kegg kegg NA NA no up up no up no Insulin secretion Drug metabolism - other enzymes -0.510434783 0 -0.576319176 yes kegg kegg NA NA no up up no no no Insulin secretion Endocrine resistance 0.86 0.818181818 0.763963964 yes kegg kegg NA NA no up up no no no Insulin secretion Endocytosis 0 -0.669960474 0 yes kegg kegg NA NA no up up no no no Insulin secretion Ether lipid metabolism 0.439130435 0.454545455 0 yes kegg kegg NA NA no up up no no no Insulin secretion Fatty acid biosynthesis -0.568695652 -0.441699605 0 yes kegg kegg NA NA no up up no no no Insulin secretion Fatty acid degradation -0.667826087 -0.523715415 -0.784041184 yes kegg kegg NA NA no up up no no no Insulin secretion Fatty acid elongation 0 -0.520750988 -0.514028314 yes kegg kegg NA NA no up up no no no Insulin secretion Fatty acid metabolism -0.643478261 -0.632411067 -0.719176319 yes kegg kegg NA NA no up up no no no Insulin secretion Fc gamma R-mediated phagocytosis -0.715652174 -0.753952569 -0.437837838 yes kegg kegg NA NA no up up no no no Insulin secretion Fructose and mannose metabolism 0 0 -0.507850708 yes kegg kegg NA NA no up up no no no Insulin secretion GABAergic synapse -0.5 0 0 yes kegg kegg NA NA no up up no up up Insulin secretion Galactose metabolism 0 -0.449604743 -0.525868726 yes kegg kegg NA NA no up up no no no Insulin secretion Gap junction 0.720869565 0.640316206 0.560875161 yes kegg kegg NA NA no up up no no no Insulin secretion Glutamatergic synapse 0.488695652 0 0.497554698 yes kegg kegg NA NA no up up no up up Insulin secretion Glutathione metabolism 0 0.447628458 0 yes kegg kegg NA NA no up up no no no Insulin secretion "Glycine, serine and threonine metabolism" 0.448695652 0.518774704 0 yes kegg kegg NA NA no up up no up no Insulin secretion Glycolysis / Gluconeogenesis 0 0 -0.542857143 yes kegg kegg NA NA no up up no no no Insulin secretion Glycosaminoglycan biosynthesis - keratan sulfate 0.602608696 0 0 yes kegg kegg NA NA no up up no no no Insulin secretion Glycosaminoglycan degradation 0 -0.636363636 -0.46048906 yes kegg kegg NA NA no up up no no up Insulin secretion Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.464426877 0 yes kegg kegg NA NA no up up no no no Insulin secretion Glyoxylate and dicarboxylate metabolism -0.528695652 -0.433794466 0 yes kegg kegg NA NA no up up no no no Insulin secretion Hedgehog signaling pathway 0.422608696 0 0 yes kegg kegg NA NA no up up no no no Insulin secretion Hippo signaling pathway - multiple species -0.48173913 0 0 yes kegg kegg NA NA no up up no no no Insulin secretion Histidine metabolism -0.409565217 0 -0.719433719 yes kegg kegg NA NA no up up no no no Insulin secretion IL-17 signaling pathway -0.512173913 -0.584980237 0 yes kegg kegg NA NA no up up no no no Insulin secretion Inflammatory mediator regulation of TRP channels 0.657391304 0.650197628 0.748519949 yes kegg kegg NA NA no up up no no no Insulin secretion Long-term depression 0.768695652 0.682806324 0.838095238 yes kegg kegg NA NA no up up no no no Insulin secretion Longevity regulating pathway 0.569565217 0 0 yes kegg kegg NA NA no up up no no no Insulin secretion Longevity regulating pathway - multiple species -0.41826087 -0.745059289 -0.46975547 yes kegg kegg NA NA no up up no no no Insulin secretion Lysine degradation 0 0.480237154 0 yes kegg kegg NA NA no up up no no no Insulin secretion Lysosome -0.422608696 -0.701581028 -0.42007722 yes kegg kegg NA NA no up up no no no Insulin secretion Mannose type O-glycan biosynthesis 0.468695652 0.450592885 0 yes kegg kegg NA NA no up up no no no Insulin secretion Metabolism of xenobiotics by cytochrome P450 -0.426086957 0 -0.416473616 yes kegg kegg NA NA no up up no no no Insulin secretion Mitophagy - animal 0.6 0.654150198 0 yes kegg kegg NA NA no up up no no no Insulin secretion mRNA surveillance pathway 0 0.627470356 0 yes kegg kegg NA NA no up up no no no Insulin secretion Mucin type O-glycan biosynthesis -0.436521739 0 0 yes kegg kegg NA NA no up up no no no Insulin secretion Natural killer cell mediated cytotoxicity 0 -0.557312253 0 yes kegg kegg NA NA no up up no no no Insulin secretion Necroptosis 0.560869565 0.468379447 0 yes kegg kegg NA NA no up up no no no Insulin secretion Neuroactive ligand-receptor interaction -0.654782609 -0.791501976 -0.433204633 yes kegg kegg NA NA no up up up up up Insulin secretion Neutrophil extracellular trap formation -0.553043478 -0.670948617 0 yes kegg kegg NA NA no up up no no no Insulin secretion Nicotinate and nicotinamide metabolism -0.690434783 -0.418972332 0 yes kegg kegg NA NA no up up no no no Insulin secretion NOD-like receptor signaling pathway -0.806956522 -0.418972332 0 yes kegg kegg NA NA no up up no no no Insulin secretion Non-homologous end-joining 0 -0.427865613 -0.417760618 yes kegg kegg NA NA no up up no no no Insulin secretion Odoribacter 0 -0.521546919 0 yes butyrate-producing kegg Genus NA 0.798 no up up no no no Insulin secretion Olfactory transduction -0.610434783 -0.653162055 -0.56010296 yes kegg kegg NA NA no up up no no no Insulin secretion Osteoclast differentiation -0.664347826 -0.584980237 0 yes kegg kegg NA NA no up up no no no Insulin secretion Other types of O-glycan biosynthesis 0 0.583003953 0 yes kegg kegg NA NA no up up no no no Insulin secretion Oxidative phosphorylation 0 0.498023715 0 yes kegg kegg NA NA no up up no no no Insulin secretion Pantothenate and CoA biosynthesis -0.592173913 -0.576086957 -0.585842986 yes kegg kegg NA NA no up up no no dn Insulin secretion Pentose phosphate pathway 0 -0.730237154 -0.413899614 yes kegg kegg NA NA no up up no no no Insulin secretion Peroxisome -0.73826087 -0.644268775 0 yes kegg kegg NA NA no up up no no no Insulin secretion Phagosome 0 -0.708498024 0 yes kegg kegg NA NA no up up no no no Insulin secretion Phospholipase D signaling pathway 0 0 0.508365508 yes kegg kegg NA NA no up up no up up Insulin secretion Porphyrin and chlorophyll metabolism 0.417391304 0.421936759 0 yes kegg kegg NA NA no up up no no no Insulin secretion PPAR signaling pathway -0.542608696 -0.524703557 0 yes kegg kegg NA NA no up up no no no Insulin secretion Prevotella 0 0 0.501709768 yes acetate-producing kegg Genus NA 0.287 no up up no no no Insulin secretion Primary bile acid biosynthesis 0 -0.472332016 -0.484684685 yes kegg kegg NA NA no up up no no no Insulin secretion Proteasome 0 0 -0.516087516 yes kegg kegg NA NA no up up no no no Insulin secretion Protein processing in endoplasmic reticulum 0.417391304 0.418972332 0 yes kegg kegg NA NA no up up no no no Insulin secretion Purine metabolism 0.464347826 0.537549407 0 yes kegg kegg NA NA no up up no no no Insulin secretion Pyrimidine metabolism -0.46173913 0 0 yes kegg kegg NA NA no up up no no no Insulin secretion Renin-angiotensin system -0.626956522 -0.693675889 -0.447104247 yes kegg kegg NA NA no up up no no no Insulin secretion Retinol metabolism -0.483478261 0 -0.536679537 yes kegg kegg NA NA no up up no no no Insulin secretion Ribosome 0.435652174 0.422924901 0 yes kegg kegg NA NA no up up no no no Insulin secretion RNA degradation 0 0.486166008 0 yes kegg kegg NA NA no up up no no no Insulin secretion RNA polymerase 0 0.473320158 0 yes kegg kegg NA NA no up up no no no Insulin secretion Serotonergic synapse 0 0 0.434749035 yes kegg kegg NA NA no up up no no no Insulin secretion Signaling pathways regulating pluripotency of stem cells 0 0.449604743 0 yes kegg kegg NA NA no up up no no no Insulin secretion Sphingolipid metabolism 0 0 -0.446332046 yes kegg kegg NA NA no up up no no no Insulin secretion Sphingolipid signaling pathway 0 -0.428853755 0 yes kegg kegg NA NA no up up no no no Insulin secretion Starch and sucrose metabolism -0.633043478 -0.500988142 -0.604890605 yes kegg kegg NA NA no up up no no no Insulin secretion Steroid hormone biosynthesis 0 0 -0.569111969 yes kegg kegg NA NA no up up no no no Insulin secretion Synaptic vesicle cycle -0.459130435 -0.734189723 -0.521492921 yes kegg kegg NA NA no up up no up up Insulin secretion Thermogenesis 0.426086957 0.5 0 yes kegg kegg NA NA no up up no no no Insulin secretion Tryptophan metabolism 0 0 -0.586615187 yes kegg kegg NA NA no up up no up no Insulin secretion Tyrosine metabolism 0 0 -0.455855856 yes kegg kegg NA NA no up up no no no Insulin secretion Ubiquitin mediated proteolysis 0.685217391 0.681818182 0 yes kegg kegg NA NA no up up no no no Insulin secretion "Valine, leucine and isoleucine degradation" 0 0 -0.507335907 yes kegg kegg NA NA no up up no no no Insulin secretion Vascular smooth muscle contraction 0.516521739 0.447628458 0.598455598 yes kegg kegg NA NA no up up no no no Insulin secretion Wnt signaling pathway 0.466956522 0.477272727 0 yes kegg kegg NA NA no up up no no no Insulin signaling pathway 2-Oxocarboxylic acid metabolism 0 0.429841897 0 kegg kegg NA NA no no no no no no Insulin signaling pathway ABC transporters 0 -0.4743083 0 kegg kegg NA NA no no no no up up Insulin signaling pathway Adherens junction -0.485217391 0.42687747 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Adrenergic signaling in cardiomyocytes 0 0.606719368 0 kegg kegg NA NA no no no no no up Insulin signaling pathway "Alanine, aspartate and glutamate metabolism" 0 -0.637351779 0 kegg kegg NA NA no no no no no no Insulin signaling pathway alpha-Linolenic acid metabolism 0 -0.760869565 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Aminoacyl-tRNA biosynthesis 0 0 0.407464607 kegg kegg NA NA no no no no no no Insulin signaling pathway Apelin signaling pathway 0.970434783 0.984189723 0.983268983 kegg kegg NA NA no no no no no no Insulin signaling pathway Apoptosis -0.597391304 -0.718379447 -0.604375804 kegg kegg NA NA no no no no no no Insulin signaling pathway Arginine and proline metabolism 0 -0.624505929 0 kegg kegg NA NA no no no no up no Insulin signaling pathway Arginine biosynthesis 0 -0.595849802 -0.412870013 kegg kegg NA NA no no no no no no Insulin signaling pathway Ascorbate and aldarate metabolism 0 0 0.452252252 kegg kegg NA NA no no no no no no Insulin signaling pathway Autophagy - animal 0 -0.613636364 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Autophagy - other 0.626956522 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway B cell receptor signaling pathway 0 -0.616600791 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Basal transcription factors 0.657391304 0 0.585842986 kegg kegg NA NA no no no no no no Insulin signaling pathway Base excision repair 0.54173913 0 0.566537967 kegg kegg NA NA no no no no no no Insulin signaling pathway Biosynthesis of amino acids 0 -0.456521739 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Biosynthesis of cofactors 0 0.46541502 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Butanoate metabolism 0 0.636363636 0.62960103 kegg kegg NA NA no no no no no no Insulin signaling pathway C-type lectin receptor signaling pathway 0 -0.576086957 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Cardiac muscle contraction 0 0.657114625 0 kegg kegg NA NA no no no no no up Insulin signaling pathway Cell adhesion molecules -0.470434783 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Cell cycle 0.587826087 0.482213439 0.422393822 kegg kegg NA NA no no no no no no Insulin signaling pathway Cellular senescence 0 -0.4743083 0 kegg kegg NA NA no no no no no no Insulin signaling pathway cGMP-PKG signaling pathway 0 -0.543478261 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Chemokine signaling pathway 0 -0.445652174 -0.482882883 kegg kegg NA NA no no no no no no Insulin signaling pathway Circadian rhythm 0.443478261 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Citrate cycle (TCA cycle) 0 0.622529644 0.622651223 kegg kegg NA NA no no no no no no Insulin signaling pathway Complement and coagulation cascades -0.491304348 -0.537549407 -0.465122265 kegg kegg NA NA no no no no no no Insulin signaling pathway Cysteine and methionine metabolism 0.473043478 0.830039526 0.673101673 kegg kegg NA NA no no no no no no Insulin signaling pathway DNA replication 0.559130435 0.587944664 0.674388674 kegg kegg NA NA no no no no no no Insulin signaling pathway Dopaminergic synapse 0 0.501976285 0 kegg kegg NA NA no no no no up no Insulin signaling pathway Drug metabolism - cytochrome P450 0 0.638339921 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Drug metabolism - other enzymes 0 0.633399209 0 kegg kegg NA NA no no no no no no Insulin signaling pathway ECM-receptor interaction 0 0.481225296 0 kegg kegg NA NA no no no no up up Insulin signaling pathway EGFR tyrosine kinase inhibitor resistance 0.929565217 0.976284585 0.968597169 kegg kegg NA NA no no no no no no Insulin signaling pathway Endocytosis -0.437391304 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Fanconi anemia pathway 0.485217391 0 0.523294723 kegg kegg NA NA no no no no no no Insulin signaling pathway Fatty acid biosynthesis 0 -0.662055336 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Fatty acid degradation 0 -0.493083004 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Fatty acid elongation 0 0.428853755 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Fatty acid metabolism 0 -0.451581028 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Fc epsilon RI signaling pathway 0 -0.776679842 -0.536679537 kegg kegg NA NA no no no no no no Insulin signaling pathway Fc gamma R-mediated phagocytosis -0.484347826 -0.493083004 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Focal adhesion -0.493043478 0.42687747 0 kegg kegg NA NA no no no no up up Insulin signaling pathway FoxO signaling pathway 0 -0.579051383 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Fructose and mannose metabolism 0 -0.662055336 0 kegg kegg NA NA no no no no no no Insulin signaling pathway GABAergic synapse 0 -0.45256917 -0.418790219 kegg kegg NA NA no no no no up up Insulin signaling pathway Galactose metabolism 0 -0.696640316 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Gap junction 0 0 -0.447876448 kegg kegg NA NA no no no no no no Insulin signaling pathway Glutamatergic synapse 0 -0.486166008 -0.464092664 kegg kegg NA NA no no no no up up Insulin signaling pathway Glutathione metabolism 0 0.701581028 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Glycerolipid metabolism 0 -0.624505929 0 kegg kegg NA NA no no no no no up Insulin signaling pathway Glycerophospholipid metabolism 0 -0.491106719 0 kegg kegg NA NA no no no no no up Insulin signaling pathway Glycolysis / Gluconeogenesis 0 0.709486166 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.7756917 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Glycosaminoglycan degradation 0 -0.571146245 0 kegg kegg NA NA no no no no no up Insulin signaling pathway Glycosphingolipid biosynthesis - globo and isoglobo series 0 0 -0.407979408 kegg kegg NA NA no no no no no no Insulin signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0 -0.46541502 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Glyoxylate and dicarboxylate metabolism 0 -0.561264822 0 kegg kegg NA NA no no no no no no Insulin signaling pathway HIF-1 signaling pathway 0.923478261 0.950592885 0.925868726 kegg kegg NA NA no no no no no no Insulin signaling pathway Hippo signaling pathway 0 0.486166008 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Hippo signaling pathway - multiple species 0 -0.731225296 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Homologous recombination 0 0 0.463835264 kegg kegg NA NA no no no no no no Insulin signaling pathway IL-17 signaling pathway 0 -0.507905138 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Inflammatory mediator regulation of TRP channels 0 0.599802372 0 kegg kegg NA NA no no no no no no Insulin signaling pathway JAK-STAT signaling pathway 0 -0.740118577 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Leukocyte transendothelial migration -0.550434783 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Long-term potentiation 0.416521739 0.70256917 0 kegg kegg NA NA no no no no no up Insulin signaling pathway Lysine degradation 0.648695652 0 0.402574003 kegg kegg NA NA no no no no no no Insulin signaling pathway Lysosome -0.467826087 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Metabolism of xenobiotics by cytochrome P450 0 0.579051383 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Mismatch repair 0 0.549407115 0.554182754 kegg kegg NA NA no no no no no no Insulin signaling pathway Mitophagy - animal 0.408695652 0.550395257 0 kegg kegg NA NA no no no no no no Insulin signaling pathway mRNA surveillance pathway 0.533043478 0.56916996 0.502702703 kegg kegg NA NA no no no no no no Insulin signaling pathway mTOR signaling pathway 0.944347826 0.975296443 0.924581725 kegg kegg NA NA no no no no no no Insulin signaling pathway N-Glycan biosynthesis 0.506086957 0.638339921 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Natural killer cell mediated cytotoxicity -0.449565217 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Neuroactive ligand-receptor interaction 0 -0.441699605 0 kegg kegg NA NA no no no up up up Insulin signaling pathway Neutrophil extracellular trap formation -0.633043478 -0.559288538 0 kegg kegg NA NA no no no no no no Insulin signaling pathway NF-kappa B signaling pathway 0 -0.730237154 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Nicotinate and nicotinamide metabolism 0 -0.722332016 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Nitrogen metabolism -0.426956522 -0.531620553 -0.474646075 kegg kegg NA NA no no no no no no Insulin signaling pathway NOD-like receptor signaling pathway 0 -0.602766798 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Non-homologous end-joining 0 0.531620553 0.432689833 kegg kegg NA NA no no no no no no Insulin signaling pathway Notch signaling pathway 0 -0.457509881 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Nucleotide excision repair 0.496521739 0.460474308 0.598712999 kegg kegg NA NA no no no no no no Insulin signaling pathway Olfactory transduction 0 -0.437747036 0 kegg kegg NA NA no no no no no no Insulin signaling pathway One carbon pool by folate 0.409565217 0 0.436036036 kegg kegg NA NA no no no no no no Insulin signaling pathway Oocyte meiosis 0.528695652 0.726284585 0.450707851 kegg kegg NA NA no no no no no no Insulin signaling pathway Osteoclast differentiation 0 -0.643280632 -0.435521236 kegg kegg NA NA no no no no no no Insulin signaling pathway Other glycan degradation 0 -0.555335968 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Other types of O-glycan biosynthesis 0.532173913 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Oxidative phosphorylation 0 0.677865613 0 kegg kegg NA NA no no no no no no Insulin signaling pathway p53 signaling pathway 0.457391304 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Pantothenate and CoA biosynthesis 0 -0.699604743 0 kegg kegg NA NA no no no no no dn Insulin signaling pathway Parabacteroides 0 0 -0.414183668 kegg Genus NA 4.19E-05 no no no no up up Insulin signaling pathway Pentose and glucuronate interconversions 0 0.625494071 0.553153153 kegg kegg NA NA no no no no no no Insulin signaling pathway Pentose phosphate pathway -0.470434783 -0.509881423 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Peroxisome 0 -0.581027668 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Phagosome -0.630434783 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Phospholipase D signaling pathway -0.42 -0.829051383 -0.618018018 kegg kegg NA NA no no no no up up Insulin signaling pathway Phototransduction 0 0.609683794 0 kegg kegg NA NA no no no no no no Insulin signaling pathway PI3K-Akt signaling pathway 0.657391304 0.574110672 0.894208494 yes kegg kegg NA NA no no no no up up Insulin signaling pathway Platelet activation -0.535652174 0 -0.41981982 kegg kegg NA NA no no no no no no Insulin signaling pathway PPAR signaling pathway 0 -0.477272727 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Propanoate metabolism 0 0.837944664 0.743114543 kegg kegg NA NA no no no no no no Insulin signaling pathway Proteasome 0.45826087 0.590909091 0.553410553 kegg kegg NA NA no no no no no no Insulin signaling pathway Protein export 0.68 0.793478261 0.641441441 kegg kegg NA NA no no no no no no Insulin signaling pathway Protein processing in endoplasmic reticulum 0.473913043 0.670948617 0.512998713 kegg kegg NA NA no no no no no no Insulin signaling pathway Pyruvate metabolism 0.407826087 0.859683794 0.616216216 kegg kegg NA NA no no no no no no Insulin signaling pathway Rap1 signaling pathway -0.549565217 0 -0.426512227 kegg kegg NA NA no no no no no no Insulin signaling pathway Ras signaling pathway 0 0.536561265 0 yes kegg kegg NA NA no no no no up up Insulin signaling pathway Regulation of actin cytoskeleton 0 0.458498024 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Renin-angiotensin system 0 -0.46541502 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Retinol metabolism 0 0 0.42007722 kegg kegg NA NA no no no no no no Insulin signaling pathway Retrograde endocannabinoid signaling 0 0.714426877 0 kegg kegg NA NA no no no no no up Insulin signaling pathway Ribosome 0.703478261 0.896245059 0.77992278 kegg kegg NA NA no no no no no no Insulin signaling pathway Ribosome biogenesis in eukaryotes 0.695652174 0.416007905 0.589446589 kegg kegg NA NA no no no no no no Insulin signaling pathway RIG-I-like receptor signaling pathway 0 -0.634387352 0 kegg kegg NA NA no no no no no no Insulin signaling pathway RNA degradation 0.566086957 0.710474308 0.612870013 kegg kegg NA NA no no no no no no Insulin signaling pathway RNA polymerase 0.640869565 0.586956522 0.631917632 kegg kegg NA NA no no no no no no Insulin signaling pathway RNA transport 0.562608696 0.935770751 0.728185328 kegg kegg NA NA no no no no no no Insulin signaling pathway Selenocompound metabolism 0.553913043 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Serotonergic synapse 0 0 -0.567052767 kegg kegg NA NA no no no no no no Insulin signaling pathway SNARE interactions in vesicular transport 0 -0.641304348 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Spliceosome 0.652173913 0 0.537709138 kegg kegg NA NA no no no no no no Insulin signaling pathway Starch and sucrose metabolism 0 -0.760869565 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Steroid biosynthesis 0.415652174 0 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Synaptic vesicle cycle 0 -0.491106719 0 kegg kegg NA NA no no no no up up Insulin signaling pathway Synthesis and degradation of ketone bodies 0.416521739 0.420948617 0.482110682 kegg kegg NA NA no no no no no no Insulin signaling pathway Taurine and hypotaurine metabolism 0 -0.515810277 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Terpenoid backbone biosynthesis 0.53826087 0 0.487516088 kegg kegg NA NA no no no no no no Insulin signaling pathway TGF-beta signaling pathway 0 0.776679842 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Thermogenesis 0 0.748023715 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Thiamine metabolism 0 0.785573123 0 kegg kegg NA NA no no no no no no Insulin signaling pathway TNF signaling pathway 0 -0.596837945 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Toll-like receptor signaling pathway 0 -0.62055336 0 yes kegg kegg NA NA no no no no no no Insulin signaling pathway Tryptophan metabolism 0 0.424901186 0.561389961 kegg kegg NA NA no no no no up no Insulin signaling pathway Tyrosine metabolism 0 0.511857708 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 0 0.501158301 kegg kegg NA NA no no no no no no Insulin signaling pathway Ubiquitin mediated proteolysis 0.45826087 0.580039526 0 kegg kegg NA NA no no no no no no Insulin signaling pathway "Valine, leucine and isoleucine degradation" 0 0.461462451 0.566537967 kegg kegg NA NA no no no no no no Insulin signaling pathway Various types of N-glycan biosynthesis 0.607826087 0.515810277 0.438867439 kegg kegg NA NA no no no no no no Insulin signaling pathway Vascular smooth muscle contraction 0 0.52173913 0 kegg kegg NA NA no no no no no no Insulin signaling pathway Wnt signaling pathway 0 0.615612648 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production ABC transporters 0 -0.550395257 0 kegg kegg NA NA no no no no up up Intestinal immune network for IgA production Adherens junction 0 0.440711462 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production alpha-Linolenic acid metabolism 0 -0.5 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Amino sugar and nucleotide sugar metabolism -0.495652174 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Antifolate resistance -0.434782609 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Apoptosis - multiple species 0 -0.485177866 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Axon guidance 0 0.669960474 0 kegg kegg NA NA no no no no up up Intestinal immune network for IgA production Bifidobacterium -0.407914774 0 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Intestinal immune network for IgA production Calcium signaling pathway 0.442608696 0 0 kegg kegg NA NA no no no no up up Intestinal immune network for IgA production Carbon metabolism 0 0.466403162 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Clostridium 0 0.480876184 0 kegg Genus NA 0.925 no no no no no no Intestinal immune network for IgA production Cysteine and methionine metabolism -0.408695652 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production ErbB signaling pathway 0.488695652 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Focal adhesion 0 0.43972332 0 kegg kegg NA NA no no no no up up Intestinal immune network for IgA production Folate biosynthesis -0.507826087 0.4743083 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production FoxO signaling pathway 0 -0.425889328 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Fusobacterium 0 -0.415694842 0 kegg Genus NA 0.628 no no no no no no Intestinal immune network for IgA production Glycerolipid metabolism 0 -0.42687747 0 kegg kegg NA NA no no no no no up Intestinal immune network for IgA production Glycerophospholipid metabolism 0 -0.562252964 0 kegg kegg NA NA no no no no no up Intestinal immune network for IgA production Glycolysis / Gluconeogenesis 0 0.475296443 0.401544402 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.579051383 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Hematopoietic cell lineage 0 0.584980237 0.622908623 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production HIF-1 signaling pathway 0 0.483201581 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Hippo signaling pathway 0 0.43083004 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Homologous recombination 0 -0.447628458 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Inositol phosphate metabolism 0 -0.446640316 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production JAK-STAT signaling pathway 0 -0.416996047 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Lachnospira -0.433043478 0 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Intestinal immune network for IgA production Leukocyte transendothelial migration 0 0.606719368 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Longevity regulating pathway 0 -0.546442688 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Mucin type O-glycan biosynthesis -0.430434783 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Neuroactive ligand-receptor interaction -0.580869565 0 0 kegg kegg NA NA no no no up up up Intestinal immune network for IgA production p53 signaling pathway 0 -0.556324111 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Propanoate metabolism -0.475652174 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Protein export 0 0.415019763 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Selenocompound metabolism 0 -0.471343874 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Sphingolipid metabolism 0 0.479249012 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Sphingolipid signaling pathway 0 0.451581028 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Starch and sucrose metabolism -0.539130435 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Steroid hormone biosynthesis -0.428695652 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Taurine and hypotaurine metabolism 0 -0.450592885 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production TGF-beta signaling pathway 0 0.432806324 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Th1 and Th2 cell differentiation 0.517391304 0 0.675675676 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Th17 cell differentiation 0.58173913 0 0.712483912 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Thiamine metabolism -0.568695652 0 0 kegg kegg NA NA no no no no no no Intestinal immune network for IgA production Tight junction 0 0.429841897 0 kegg kegg NA NA no no no no no no IP-10 14:0/16:0-PC+blood 0 0 0.763909774 serum_cytokines serum_phospholipids 0.394 0.0358 no no no no up no IP-10 14:0/18:2-PC+blood 0 0 0.630075188 serum_cytokines serum_phospholipids 0.394 0.102 no no no no up no IP-10 14:0+blood 0 0 0.469172932 yes serum_cytokines serum_fattyacid 0.394 0.00572 no no no up no dn IP-10 16:0/16:1-PC+blood 0 0.514285714 0.744360902 serum_cytokines serum_phospholipids 0.394 0.00283 no no no up up no IP-10 16:0/18:2-PI+blood 0 0 0.660150376 serum_cytokines serum_phospholipids 0.394 0.269 no no no no no no IP-10 16:0/18:3-PC+blood 0 0 0.607518797 serum_cytokines serum_phospholipids 0.394 0.00216 no no no no up up IP-10 16:0/20:3-PC+blood 0 0.535714286 0 serum_cytokines serum_phospholipids 0.394 5.43E-06 no no no no up up IP-10 16:0/20:4-PI+blood 0 0 0.688721805 serum_cytokines serum_phospholipids 0.394 0.558 no no no no no no IP-10 16:0/22:6-PE+blood 0 0 0.44962406 serum_cytokines serum_phospholipids 0.394 0.000934 no no no up up no IP-10 18:0/18:0-PC+blood 0 0.767857143 0 serum_cytokines serum_phospholipids 0.394 0.426 no no no no no no IP-10 18:0/18:1-PC+blood 0 0.771428571 0 serum_cytokines serum_phospholipids 0.394 0.393 no no no no no no IP-10 18:0/20:2-PC+blood 0 0.757142857 0 serum_cytokines serum_phospholipids 0.394 0.733 no no no no no no IP-10 18:0/20:3-PC+blood 0 0.760714286 0 serum_cytokines serum_phospholipids 0.394 0.0682 no no no no up no IP-10 18:0/20:5-PC+blood 0 0 -0.54887218 serum_cytokines serum_phospholipids 0.394 0.17 no no no no no no IP-10 18:1-LPC+blood 0 0 -0.446616541 serum_cytokines serum_phospholipids 0.394 0.179 no no no no no no IP-10 18:1/20:4-PC+blood -0.636363636 0 -0.461654135 serum_cytokines serum_phospholipids 0.394 0.582 no no no no no no IP-10 18:3n6+blood 0 0 0.452631579 serum_cytokines serum_fattyacid 0.394 0.0463 no no no up no dn IP-10 20:2/18:0-PC+blood 0 0.771428571 0 serum_cytokines serum_phospholipids 0.394 0.0427 no no no no up no IP-10 20:3n6+blood 0 0.575 0 serum_cytokines serum_fattyacid 0.394 0.0884 no no no up no no IP-10 20:4/18:0-PE+blood 0 -0.596428571 0 serum_cytokines serum_phospholipids 0.394 0.000755 no no no up up no IP-10 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 0.507352941 serum_cytokines stool_cometabolism 0.394 0.33 no no no no no no IP-10 AA+blood 0 -0.582142857 -0.520300752 serum_cytokines serum_ARA 0.394 0.212 no no no no no no IP-10 Alcoholism 0 -0.566917293 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Aldosterone synthesis and secretion 0 0 0.499726327 serum_cytokines kegg 0.394 NA no no no no up up IP-10 Alzheimer disease -0.653846154 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Amphetamine addiction 0 0 0.54077723 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Amyotrophic lateral sclerosis -0.659340659 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Bacterial invasion of epithelial cells 0 0 -0.442802408 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Betaine+blood 0 0 -0.645112782 serum_cytokines serum_choline 0.394 0.857 no no no no no no IP-10 Biosynthesis of amino acids 0 0 -0.522714833 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Butyricicoccus 0 0 -0.411206615 butyrate-producing serum_cytokines Genus 0.394 0.852 no no no no no no IP-10 Carbon metabolism 0 0 -0.690202518 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Cardiac muscle contraction -0.653846154 0 0 serum_cytokines kegg 0.394 NA no no no no no up IP-10 CDCA+stool 0 0.629370629 0 serum_cytokines stool_bileacids 0.394 0.663 no no no no no no IP-10 Collinsella 0.613480635 0 0 serum_cytokines Genus 0.394 0.128 no no no no no no IP-10 d18:0-24:1-SM+blood 0 0.596428571 0 serum_cytokines serum_phospholipids 0.394 0.0609 no no no no dn dn IP-10 d18:1-22:0-SM+blood 0 0.607142857 0 serum_cytokines serum_phospholipids 0.394 0.522 no no no no no no IP-10 Diabetic cardiomyopathy -0.626373626 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Dopaminergic synapse 0 0 0.603174603 serum_cytokines kegg 0.394 NA no no no no up no IP-10 Faecalibacterium -0.554945055 0 0 butyrate-producing serum_cytokines Genus 0.394 0.0039 no no no no dn dn IP-10 Fc gamma R-mediated phagocytosis 0 0 -0.465790914 serum_cytokines kegg 0.394 NA no no no no no no IP-10 FGF basic -0.587912088 0 0 serum_cytokines serum_cytokines 0.394 0.65 no no no no no no IP-10 GDCA+blood 0 -0.6 0 serum_cytokines serum_bileacids 0.394 0.632 no no no no no no IP-10 GDCA+stool 0 0.584939601 0 serum_cytokines stool_bileacids 0.394 0.656 no no no no no no IP-10 Glucagon signaling pathway 0 0 0.409961686 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Glycolysis / Gluconeogenesis 0 0 -0.432950192 serum_cytokines kegg 0.394 NA no no no no no no IP-10 GnRH signaling pathway 0 0 0.46031746 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Homovanillic acid+urine 0 -0.511764706 0 serum_cytokines urine_cometabolism 0.394 0.45 no no no no no no IP-10 Huntington disease -0.648351648 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 IFN-g -0.554945055 -0.664935065 0 serum_cytokines serum_cytokines 0.394 0.825 no no no no no no IP-10 IL-2 0 -0.51038961 -0.435372636 serum_cytokines serum_cytokines 0.394 0.522 no no no no no no IP-10 IL-6 0 -0.506493506 -0.537708565 serum_cytokines serum_cytokines 0.394 0.52 no no no no no no IP-10 Inflammatory mediator regulation of TRP channels 0 0 0.422550629 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Insulin resistance -0.71978022 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 iso-DCA+blood 0 -0.585714286 0 serum_cytokines serum_bileacids 0.394 0.38 no no no no no no IP-10 L-2-Aminobutyric acid+blood 0 0 -0.52481203 yes serum_cytokines serum_aminoacids 0.394 0.000328 no no no up up no IP-10 L-Citrulline+blood 0 0 -0.595488722 serum_cytokines serum_aminoacids 0.394 0.534 no no no no no no IP-10 L-Glutamine+blood 0 0 -0.554887218 serum_cytokines serum_aminoacids 0.394 0.639 no no no no no no IP-10 L-Homocystine+blood -0.793939394 0 0 serum_cytokines serum_aminoacids 0.394 0.197 no no no no no no IP-10 L-Ornithine+blood 0 0 -0.529323308 serum_cytokines serum_aminoacids 0.394 0.175 no no no no no no IP-10 L-Tryptophan+blood 0 0 -0.455639098 serum_cytokines serum_aminoacids 0.394 0.164 no no no no no no IP-10 L-Tryptophan+urine -0.745454545 0 0 serum_cytokines urine_cometabolism 0.394 0.226 no no no no no no IP-10 L-Tyrosine+blood 0 0.564285714 0 yes serum_cytokines serum_aminoacids 0.394 0.00913 no no no up up no IP-10 Leukocyte transendothelial migration 0 0 -0.524356869 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Lysosome 0 0 -0.458128079 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Melanogenesis 0 0 0.471811713 serum_cytokines kegg 0.394 NA no no no no no no IP-10 MicroRNAs in cancer -0.626373626 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Neuroactive ligand-receptor interaction 0 0 -0.564860427 serum_cytokines kegg 0.394 NA no no no up up up IP-10 Neurotrophin signaling pathway -0.554945055 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Neutrophil extracellular trap formation 0 0 -0.535851122 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Non-alcoholic fatty liver disease -0.631868132 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Oxidative phosphorylation -0.648351648 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 p53 signaling pathway 0 0 0.45320197 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Paraprevotella 0 0.501933551 0 serum_cytokines Genus 0.394 0.118 no no no no no no IP-10 "Parathyroid hormone synthesis, secretion and action" -0.554945055 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Pathogenic Escherichia coli infection 0 0 -0.616858238 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Pathways in cancer -0.571428571 0 0.446086481 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Peroxisome 0 0 -0.403393541 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Porphyrin and chlorophyll metabolism 0.582417582 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Progesterone-mediated oocyte maturation -0.642857143 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Prostate cancer -0.593406593 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Rheumatoid arthritis 0 0 -0.51833607 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Roseburia 0 0.488470308 0 butyrate-producing serum_cytokines Genus 0.394 0.495 no no no no no no IP-10 Ruminococcus 0 0.537662338 0 acetate-producing serum_cytokines Genus 0.394 0.335 no no no no no no IP-10 Salmonella infection 0 0 -0.646414888 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Sarcina 0 0.509647191 0 serum_cytokines Genus 0.394 0.0703 no no no no no no IP-10 Sarcosine+blood 0 0 0.587969925 serum_cytokines serum_choline 0.394 5.06E-05 no no no up up no IP-10 Signaling pathways regulating pluripotency of stem cells -0.648351648 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Small cell lung cancer 0 0 0.473453749 serum_cytokines kegg 0.394 NA no no no no no up IP-10 Staphylococcus aureus infection 0 0 -0.546250684 serum_cytokines kegg 0.394 NA no no no up no no IP-10 Systemic lupus erythematosus 0 0 -0.521620142 serum_cytokines kegg 0.394 NA no no no no no no IP-10 TDCA+blood 0 -0.604367223 0 yes serum_cytokines serum_bileacids 0.394 0.155 no no no no up no IP-10 Thermogenesis -0.554945055 0 0 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Thyroid cancer 0 0 0.499178982 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Tight junction 0 0 -0.443349754 serum_cytokines kegg 0.394 NA no no no no no no IP-10 Tuberculosis 0 0 -0.555555556 serum_cytokines kegg 0.394 NA no no no no no dn IP-10 TXB2+blood 0.650458932 0 0 yes serum_cytokines serum_ARA 0.394 0.0644 no no no dn no no IP-10 Valine+blood 0 0 -0.49924812 yes serum_cytokines serum_aminoacids 0.394 1.22E-06 no no no up up no iso-DCA+blood 12-ketoDCA+blood -0.48720945 0 0 serum_bileacids serum_bileacids 0.38 0.517 no no no no no no iso-DCA+blood 13-HODE+blood 0.455639098 0.482843137 0 serum_bileacids serum_ARA 0.38 0.32 no no no no no no iso-DCA+blood 15-HETE+blood 0 -0.498159899 0 serum_bileacids serum_ARA 0.38 0.819 no no no no no no iso-DCA+blood 16:0-LPE+blood -0.631578947 0 0 serum_bileacids serum_phospholipids 0.38 0.0711 no no no up up no iso-DCA+blood 16:0/14:0-PC+blood 0.556390977 0 0.549401709 serum_bileacids serum_phospholipids 0.38 0.0206 no no no no up up iso-DCA+blood 16:0/16:0-PC+blood 0.554887218 0 0.402393162 serum_bileacids serum_phospholipids 0.38 0.00079 no no no no up up iso-DCA+blood 16:0/16:1-PI+blood -0.589473684 0 0 serum_bileacids serum_phospholipids 0.38 0.262 no no no no no no iso-DCA+blood 16:0/18:0-PS+blood 0 0 -0.465982906 serum_bileacids serum_phospholipids 0.38 0.377 no no no no no no iso-DCA+blood 16:0/18:1-PC+blood 0.518796992 0 0 serum_bileacids serum_phospholipids 0.38 6.15E-07 no no no up up up iso-DCA+blood 16:0/18:1-PE+blood -0.44962406 0 0 serum_bileacids serum_phospholipids 0.38 0.000107 no no no up up no iso-DCA+blood 16:0/18:2-PC+blood 0.559398496 0 0.561709402 serum_bileacids serum_phospholipids 0.38 3.24E-06 no no no no up up iso-DCA+blood 16:0/20:3-PC+blood 0.798496241 0 0.410598291 serum_bileacids serum_phospholipids 0.38 5.43E-06 no no no no up up iso-DCA+blood 16:0/20:4-PC+blood 0.479699248 0 0 serum_bileacids serum_phospholipids 0.38 0.0262 no no no no up no iso-DCA+blood 16:0/20:4-PE+blood -0.490225564 0 0 serum_bileacids serum_phospholipids 0.38 0.00139 no no no up up no iso-DCA+blood 16:0/20:4-PI+blood -0.467669173 -0.610294118 0 serum_bileacids serum_phospholipids 0.38 0.558 no no no no no no iso-DCA+blood 16:1/16:0-PC+blood 0.517293233 0 0 serum_bileacids serum_phospholipids 0.38 0.0215 no no no no up up iso-DCA+blood 16:1/16:1-PC+blood 0.544360902 0 0 serum_bileacids serum_phospholipids 0.38 0.0177 no no no no no up iso-DCA+blood 16:1/18:1-PG+blood 0 0 -0.414017094 serum_bileacids serum_phospholipids 0.38 3.21E-05 no no no no up up iso-DCA+blood 16:1/18:2-PG+blood 0.658646617 0 0 serum_bileacids serum_phospholipids 0.38 1.40E-08 no no no no up up iso-DCA+blood 18:0-LPE+blood -0.473684211 0 0 serum_bileacids serum_phospholipids 0.38 0.491 no no no no no no iso-DCA+blood 18:0/16:0-PC+blood 0.472180451 0 0 serum_bileacids serum_phospholipids 0.38 9.64E-07 no no no up up up iso-DCA+blood 18:0/18:0-PE+blood -0.593984962 0 -0.413333333 serum_bileacids serum_phospholipids 0.38 0.00896 no no no up up no iso-DCA+blood 18:0/18:0-PS+blood 0 0 -0.417435897 serum_bileacids serum_phospholipids 0.38 0.00617 no no no no up no iso-DCA+blood 18:0/18:1-PE+blood -0.618045113 0 0 serum_bileacids serum_phospholipids 0.38 0.00716 no no no up up no iso-DCA+blood 18:0/18:1-PG+blood -0.472180451 0 0 serum_bileacids serum_phospholipids 0.38 0.000842 no no no no up no iso-DCA+blood 18:0/18:2-PC+blood 0.693233083 0 0.535042735 serum_bileacids serum_phospholipids 0.38 1.74E-06 no no no no up up iso-DCA+blood 18:0/20:4-PC+blood 0.460150376 0 0 serum_bileacids serum_phospholipids 0.38 0.454 no no no no no no iso-DCA+blood 18:0+blood 0 0 0.483076923 serum_bileacids serum_fattyacid 0.38 0.344 no no no no no no iso-DCA+blood 18:1/16:0-PC+blood 0.512781955 0 0.540512821 serum_bileacids serum_phospholipids 0.38 2.43E-05 no no no no up up iso-DCA+blood 18:1/16:0-PE+blood -0.508270677 0 0 serum_bileacids serum_phospholipids 0.38 0.000182 no no no up up no iso-DCA+blood 18:1/16:0-PI+blood -0.44962406 0 0 serum_bileacids serum_phospholipids 0.38 0.793 no no no no no no iso-DCA+blood 18:1/16:1-PE+blood -0.49924812 0 0 serum_bileacids serum_phospholipids 0.38 0.000184 no no no up up no iso-DCA+blood 18:1/18:0-PC+blood 0.703759398 0 0.537094017 serum_bileacids serum_phospholipids 0.38 1.83E-06 no no no no up up iso-DCA+blood 18:1/18:0-PS+blood 0 -0.492647059 0 serum_bileacids serum_phospholipids 0.38 0.193 no no no no no no iso-DCA+blood 18:1/18:1-PC+blood 0.756390977 0 0 serum_bileacids serum_phospholipids 0.38 1.34E-05 no no no no up up iso-DCA+blood 18:1/18:2-PG+blood 0.669172932 0 0 serum_bileacids serum_phospholipids 0.38 5.58E-07 no no no no up up iso-DCA+blood 18:1/20:3-PC+blood 0.633082707 0 0 serum_bileacids serum_phospholipids 0.38 0.00872 no no no no up up iso-DCA+blood 18:2-LPA+blood 0.521804511 0 0 serum_bileacids serum_phospholipids 0.38 0.00684 no no no dn no up iso-DCA+blood 18:2/16:0-PC+blood 0.787969925 0 0.411282051 serum_bileacids serum_phospholipids 0.38 8.67E-05 no no no no up up iso-DCA+blood 18:2/18:1-PC+blood 0.527819549 0 0 serum_bileacids serum_phospholipids 0.38 2.30E-05 no no no dn up up iso-DCA+blood 18:2/18:2-PC+blood 0.47518797 0 0 serum_bileacids serum_phospholipids 0.38 1.98E-05 no no no dn up up iso-DCA+blood 18:2n6c+blood 0 0 0.425641026 serum_bileacids serum_fattyacid 0.38 0.15 no no no no no no iso-DCA+blood 18:3n3+blood 0 0 0.444102564 serum_bileacids serum_fattyacid 0.38 0.291 no no no no no no iso-DCA+blood 20:1-LPA+blood 0.496240602 0 0 serum_bileacids serum_phospholipids 0.38 0.0187 no no no dn dn no iso-DCA+blood 20:2-LPC+blood 0.664661654 0 0.535726496 serum_bileacids serum_phospholipids 0.38 0.119 no no no no no up iso-DCA+blood 20:2+blood 0.560902256 0 0.404444444 serum_bileacids serum_fattyacid 0.38 0.478 no no no no no no iso-DCA+blood 20:3/16:0-PC+blood 0.49924812 0 0.414700855 serum_bileacids serum_phospholipids 0.38 0.00405 no no no no up up iso-DCA+blood AA+blood 0.455639098 0 0 serum_bileacids serum_ARA 0.38 0.212 no no no no no no iso-DCA+blood Acute myeloid leukemia 0 0 0.436923077 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Adherens junction 0 0 -0.48 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Adrenergic signaling in cardiomyocytes 0 0 -0.414615385 serum_bileacids kegg 0.38 NA no no no no no up iso-DCA+blood Alzheimer disease 0 0 -0.491538462 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Amphetamine addiction 0 0 -0.406153846 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Amyotrophic lateral sclerosis 0 0 -0.529230769 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Arginine and proline metabolism 0 0 0.426923077 serum_bileacids kegg 0.38 NA no no no no up no iso-DCA+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.463076923 serum_bileacids kegg 0.38 NA no no no no up up iso-DCA+blood B cell receptor signaling pathway 0 0 0.423846154 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Butyricimonas 0 -0.538411071 0 butyrate-producing serum_bileacids Genus 0.38 0.17 no no no no no no iso-DCA+blood Cardiac muscle contraction 0 0 -0.536153846 serum_bileacids kegg 0.38 NA no no no no no up iso-DCA+blood Choline+blood 0 0 0.483076923 serum_bileacids serum_choline 0.38 0.0395 no no no no up no iso-DCA+blood Chronic myeloid leukemia 0 0 0.462307692 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Creatinine+blood 0 0.536764706 0 serum_bileacids serum_choline 0.38 0.437 no no no no no no iso-DCA+blood Cysteine+blood 0.569924812 0 0.565811966 yes serum_bileacids serum_aminoacids 0.38 1.81E-07 no no no dn up up iso-DCA+blood d18:1-14:0-SM+blood 0 0 -0.515897436 serum_bileacids serum_phospholipids 0.38 0.94 no no no no no no iso-DCA+blood d18:1-18:0-SM+blood 0.476691729 0 0 serum_bileacids serum_phospholipids 0.38 0.97 no no no no no no iso-DCA+blood d18:1-20:1-SM+blood 0.463157895 0 0 serum_bileacids serum_phospholipids 0.38 0.0992 no no no no no no iso-DCA+blood Diabetic cardiomyopathy 0 0 -0.507692308 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Dilated cardiomyopathy 0 0 -0.527692308 serum_bileacids kegg 0.38 NA no no no no up up iso-DCA+blood Estrogen signaling pathway 0 0 -0.423846154 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Focal adhesion 0 0 -0.546153846 serum_bileacids kegg 0.38 NA no no no no up up iso-DCA+blood Gastric acid secretion 0 0 -0.482307692 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood GCA+blood -0.461654135 0 0 yes serum_bileacids serum_bileacids 0.38 0.16 no no no no no no iso-DCA+blood GCDCA+blood -0.541353383 0 0 serum_bileacids serum_bileacids 0.38 0.31 no no no no no no iso-DCA+blood GUDCA+blood -0.464661654 0 0 serum_bileacids serum_bileacids 0.38 0.0766 no no no no no dn iso-DCA+blood Hippo signaling pathway 0 0 -0.516923077 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Huntington disease 0 0 -0.429230769 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Hypertrophic cardiomyopathy 0 0 -0.423846154 serum_bileacids kegg 0.38 NA no no no no up up iso-DCA+blood Hypotaurine+blood 0 0.590686275 0 serum_bileacids serum_aminoacids 0.38 0.933 no no no no no no iso-DCA+blood IL-17 signaling pathway 0 0 0.430769231 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Inflammatory mediator regulation of TRP channels 0 0 -0.446153846 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Melanogenesis 0 0 -0.436153846 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood NF-kappa B signaling pathway 0 0 0.486923077 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Non-alcoholic fatty liver disease 0 0 -0.539230769 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Oocyte meiosis 0 0 -0.404615385 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Oscillospira 0 0 0.42017094 LPS-producing serum_bileacids Genus 0.38 0.62 no no no no no no iso-DCA+blood Oxidative phosphorylation 0 0 -0.474615385 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Prevotella -0.455720133 0 0 acetate-producing serum_bileacids Genus 0.38 0.287 no no no no no no iso-DCA+blood Prion disease 0 0 -0.523846154 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood TCA+stool -0.558459951 0 0 serum_bileacids stool_bileacids 0.38 0.458 no no no no no no iso-DCA+blood Thermogenesis 0 0 -0.459230769 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Thyroid hormone signaling pathway 0 0 -0.482307692 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood TNF signaling pathway 0 0 0.404615385 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+blood Viral protein interaction with cytokine and cytokine receptor 0.477192982 0 0 serum_bileacids kegg 0.38 NA no no no no no no iso-DCA+stool 12-ketoDCA+stool 0 0 0.449604743 stool_bileacids stool_bileacids 0.155 0.505 no no no no no no iso-DCA+stool CA+stool -0.558307534 0 0 stool_bileacids stool_bileacids 0.155 0.827 no no no no no no iso-DCA+stool CDCA+stool -0.60371517 0 0 stool_bileacids stool_bileacids 0.155 0.663 no no no no no no iso-DCA+stool DCA+stool 0.547987616 0 0 stool_bileacids stool_bileacids 0.155 0.195 no no no no no no iso-DCA+stool GLCA+stool 0 0 0.525101769 stool_bileacids stool_bileacids 0.155 0.617 no no no no no no iso-DCA+stool HCA+stool -0.492260062 0 0 stool_bileacids stool_bileacids 0.155 0.155 no no no no no no iso-DCA+stool HDCA+stool 0.504643963 0.657342657 0 stool_bileacids stool_bileacids 0.155 0.176 no no no no no no iso-DCA+stool ¦Ø-MCA+stool -0.524555057 0 0 stool_bileacids stool_bileacids 0.155 0.919 no no no no no no iso-heptanoic acid C7+blood 14:0/18:0-PC+blood 0 0.50245098 0.403076923 serum_mcfa serum_phospholipids 0.00256 0.00289 up up no up up no iso-heptanoic acid C7+blood 16:0/16:0-PI+blood 0 0.549019608 0 serum_mcfa serum_phospholipids 0.00256 0.358 up up no no no no iso-heptanoic acid C7+blood 16:0/18:1-PC+blood 0 0 0.629401709 serum_mcfa serum_phospholipids 0.00256 6.15E-07 up up no up up up iso-heptanoic acid C7+blood 16:0/20:3-PC+blood 0 0 0.554188034 serum_mcfa serum_phospholipids 0.00256 5.43E-06 up up no no up up iso-heptanoic acid C7+blood 16:0+blood 0 0 0.467350427 yes serum_mcfa serum_fattyacid 0.00256 0.00876 up up no up no no iso-heptanoic acid C7+blood 18:0/16:0-PC+blood 0 0 0.607521368 serum_mcfa serum_phospholipids 0.00256 9.64E-07 up up no up up up iso-heptanoic acid C7+blood 18:0/20:3-PC+blood 0 0 0.437948718 serum_mcfa serum_phospholipids 0.00256 0.0682 up up no no up no iso-heptanoic acid C7+blood 18:0/20:3-PI+blood -0.460150376 0 0 serum_mcfa serum_phospholipids 0.00256 0.377 up up no no no no iso-heptanoic acid C7+blood 18:1/18:1-PC+blood 0 0 0.58017094 serum_mcfa serum_phospholipids 0.00256 1.34E-05 up up no no up up iso-heptanoic acid C7+blood 18:3n6+blood 0.533834586 -0.519607843 0 serum_mcfa serum_fattyacid 0.00256 0.0463 up up no up no dn iso-heptanoic acid C7+blood 2-methyl-butyric acid m-C4+blood 0.606015038 0 0 serum_mcfa serum_scfa 0.00256 0.262 up up no no no no iso-heptanoic acid C7+blood 20:1-LPE+blood -0.523308271 0 0 serum_mcfa serum_phospholipids 0.00256 0.465 up up no no no no iso-heptanoic acid C7+blood 20:2-LPC+blood -0.589473684 0 0 serum_mcfa serum_phospholipids 0.00256 0.119 up up no no no up iso-heptanoic acid C7+blood 20:2/18:0-PC+blood 0 0 0.419487179 serum_mcfa serum_phospholipids 0.00256 0.0427 up up no no up no iso-heptanoic acid C7+blood 20:3n6+blood 0 0 0.439316239 serum_mcfa serum_fattyacid 0.00256 0.0884 up up no up no no iso-heptanoic acid C7+blood 5-HETE+blood 0 0.482269873 0 serum_mcfa serum_ARA 0.00256 0.697 up up no no no no iso-heptanoic acid C7+blood 9-HODE+blood -0.476691729 0 0 serum_mcfa serum_ARA 0.00256 0.297 up up no no no no iso-heptanoic acid C7+blood AA+blood 0 0 -0.427692308 serum_mcfa serum_ARA 0.00256 0.212 up up no no no no iso-heptanoic acid C7+blood butyric acid C4+blood 0.52481203 0 0 serum_mcfa serum_scfa 0.00256 0.407 up up no no no no iso-heptanoic acid C7+blood capric acid C6+blood 0 0.634803922 0 serum_mcfa serum_scfa 0.00256 0.433 up up no no no no iso-heptanoic acid C7+blood decanoic acid C10+blood 0 0 0.552136752 serum_mcfa serum_mcfa 0.00256 6.64E-11 up up no dn dn no iso-heptanoic acid C7+blood DPA+blood 0 0 -0.417435897 serum_mcfa serum_ARA 0.00256 0.519 up up no no no no iso-heptanoic acid C7+blood heptanoic acid C7+blood 0.473684211 0 0 serum_mcfa serum_mcfa 0.00256 8.27E-11 up up no dn dn no iso-LCA+blood 12-ketoDCA+blood 0.501033597 0.863148791 0 serum_bileacids serum_bileacids 0.507 0.517 no no no no no no iso-LCA+blood "12,13-EPOME+blood" -0.503669365 0 0 serum_bileacids serum_ARA 0.507 0.901 no no no no no no iso-LCA+blood 14:0/18:2-PC+blood 0 0 -0.406237136 serum_bileacids serum_phospholipids 0.507 0.102 no no no no up no iso-LCA+blood 14:0/20:4-PC+blood 0 0 -0.442919452 serum_bileacids serum_phospholipids 0.507 0.486 no no no no no no iso-LCA+blood 16:0/18:0-PS+blood 0 -0.499012052 0 serum_bileacids serum_phospholipids 0.507 0.377 no no no no no no iso-LCA+blood 18:0-LPA+blood 0 -0.501879937 0 serum_bileacids serum_phospholipids 0.507 0.0725 no no no no dn no iso-LCA+blood 18:0/18:0-PS+blood 0 -0.507615708 0 serum_bileacids serum_phospholipids 0.507 0.00617 no no no no up no iso-LCA+blood 18:0/20:3-PC+blood -0.520578494 0 0 serum_bileacids serum_phospholipids 0.507 0.0682 no no no no up no iso-LCA+blood 18:0/20:3-PI+blood 0 -0.493276281 0 serum_bileacids serum_phospholipids 0.507 0.377 no no no no no no iso-LCA+blood 18:0/22:6-PE+blood 0 -0.501879937 0 serum_bileacids serum_phospholipids 0.507 0.00022 no no no up up no iso-LCA+blood 18:0/22:6-PI+blood -0.55753314 -0.613727466 0 serum_bileacids serum_phospholipids 0.507 0.425 no no no no no no iso-LCA+blood 18:2/20:4-PC+blood -0.498887723 0 0 serum_bileacids serum_phospholipids 0.507 0.0145 no no no no no up iso-LCA+blood 18:3n6+blood 0 0 -0.415993071 serum_bileacids serum_fattyacid 0.507 0.0463 no no no up no dn iso-LCA+blood 20:0-LPC+blood 0 0.673953059 0 serum_bileacids serum_phospholipids 0.507 0.199 no no no no no no iso-LCA+blood 20:2/18:0-PC+blood -0.527808751 0 0 serum_bileacids serum_phospholipids 0.507 0.0427 no no no no up no iso-LCA+blood 22:6-LPC+blood -0.518168408 0 0 serum_bileacids serum_phospholipids 0.507 0.127 no no no no no up iso-LCA+blood 22:6n3+blood -0.576010463 0 0 serum_bileacids serum_fattyacid 0.507 0.792 no no no no no no iso-LCA+blood 24:1+blood 0 -0.484672625 0 serum_bileacids serum_fattyacid 0.507 0.00582 no no no no dn dn iso-LCA+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.582276887 serum_bileacids stool_cometabolism 0.507 0.33 no no no no no no iso-LCA+blood ACA+blood 0.558798283 0 0 serum_bileacids serum_bileacids 0.507 0.338 no no no no no no iso-LCA+blood Acetic acid+stool 0.654659598 0 0 yes serum_bileacids stool_scfa 0.507 0.0656 no no no dn no no iso-LCA+blood Akkermansia -0.461802575 0 0 acetate-producing serum_bileacids Genus 0.507 0.23 no no no no no no iso-LCA+blood Alistipes 0.447148339 0 0 serum_bileacids Genus 0.507 0.0114 no no no no up no iso-LCA+blood Allograft rejection 0 0 -0.416840085 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood AMPK signaling pathway 0.606492224 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Apelin signaling pathway 0.532303572 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Autoimmune thyroid disease 0 0 -0.416840085 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Blautia -0.674823974 -0.539162447 -0.446399408 acetate-producing serum_bileacids Genus 0.507 1.36E-05 no no no up dn dn iso-LCA+blood butyric acid C4+blood 0 0.570709186 0 serum_bileacids serum_scfa 0.507 0.407 no no no no no no iso-LCA+blood CA+stool -0.807877802 0 0 serum_bileacids stool_bileacids 0.507 0.827 no no no no no no iso-LCA+blood Calcium signaling pathway 0 0.567781459 0 serum_bileacids kegg 0.507 NA no no no no up up iso-LCA+blood Carbon metabolism 0 -0.598198323 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood CDCA+stool -0.598943887 0 -0.481701789 serum_bileacids stool_bileacids 0.507 0.663 no no no no no no iso-LCA+blood Chemical carcinogenesis - receptor activation 0 0.604957626 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Clostridium -0.576008109 -0.509361855 0 serum_bileacids Genus 0.507 0.925 no no no no no no iso-LCA+blood Coronavirus disease - COVID-19 0.59350921 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Cushing syndrome 0 0.604957626 0 serum_bileacids kegg 0.507 NA no no no no no up iso-LCA+blood d18:0-18:3-SM+blood 0 0 -0.458528948 serum_bileacids serum_phospholipids 0.507 0.0879 no no no no dn no iso-LCA+blood d18:1-14:0-SM+blood 0 0 -0.495601501 serum_bileacids serum_phospholipids 0.507 0.94 no no no no no no iso-LCA+blood d18:1-14:1-SM+blood 0 0 -0.573258744 serum_bileacids serum_phospholipids 0.507 0.0952 no no no no dn no iso-LCA+blood d18:1-22:1-SM+blood 0 0.513351479 0 serum_bileacids serum_phospholipids 0.507 0.222 no no no no no no iso-LCA+blood EGFR tyrosine kinase inhibitor resistance 0.498918679 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Endocrine resistance 0 0.596508497 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Fc gamma R-mediated phagocytosis -0.510046977 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood FoxO signaling pathway 0 0 0.520181689 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood GABAergic synapse -0.46367907 0 0 serum_bileacids kegg 0.507 NA no no no no up up iso-LCA+blood GCA+stool -0.571086032 -0.705458603 0 serum_bileacids stool_bileacids 0.507 0.0809 no no no no no no iso-LCA+blood GDCA+blood 0 0.530558791 0.469065358 serum_bileacids serum_bileacids 0.507 0.632 no no no no no no iso-LCA+blood GLCA+blood 0.496237446 0.568342145 0.599761333 serum_bileacids serum_bileacids 0.507 0.319 no no no no no no iso-LCA+blood GnRH signaling pathway 0 0.66748118 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Graft-versus-host disease 0 0 -0.402945415 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood "Growth hormone synthesis, secretion and action" 0 0.62354571 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood HCA+stool -0.55994289 0 0 serum_bileacids stool_bileacids 0.507 0.155 no no no no no no iso-LCA+blood HDCA+blood 0 0.741620475 0.402647762 serum_bileacids serum_bileacids 0.507 0.483 no no no no no no iso-LCA+blood Human cytomegalovirus infection 0 0 -0.402945415 serum_bileacids kegg 0.507 NA no no no no no dn iso-LCA+blood Human immunodeficiency virus 1 infection 0 0 -0.414234834 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Hypotaurine+blood 0.461129715 0 0 serum_bileacids serum_aminoacids 0.507 0.933 no no no no no no iso-LCA+blood IL-17 signaling pathway -0.487790382 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Insulin signaling pathway 0.511901693 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood iso-LCA+stool 0.594189072 0 0.576983461 serum_bileacids stool_bileacids 0.507 0.72 no no no no no no iso-LCA+blood LCA+stool 0 0 0.46582151 serum_bileacids stool_bileacids 0.507 0.314 no no no no no no iso-LCA+blood Lipid and atherosclerosis -0.599073359 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Longevity regulating pathway - multiple species 0 -0.549193376 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Mitophagy - animal 0.506337545 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood mTOR signaling pathway 0.560124317 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Neutrophil extracellular trap formation -0.484080949 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood NOD-like receptor signaling pathway -0.476662084 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood nutriCA+stool -0.562728676 -0.65882927 0 serum_bileacids stool_bileacids 0.507 0.481 no no no no no no iso-LCA+blood Parkinson disease 0.504482828 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Pathways of neurodegeneration - multiple diseases 0.502628112 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Peroxisome -0.474807368 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Pertussis -0.634312968 0 0 serum_bileacids kegg 0.507 NA no no no no no dn iso-LCA+blood Prevotella 0.527362862 0 0 serum_bileacids Genus 0.507 0.367 no no no no no no iso-LCA+blood Propionic acid+stool 0.646302241 0 0 yes serum_bileacids stool_scfa 0.507 0.0436 no no no dn no up iso-LCA+blood Protein processing in endoplasmic reticulum 0.489645098 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Proteoglycans in cancer 0.504482828 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Renal cell carcinoma 0.482226233 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Ribosome 0.59350921 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Salmonella infection 0 -0.512017209 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Shigellosis 0.556414884 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood total_stool_scfa+stool 0.674160097 0 0 serum_bileacids stool_scfa 0.507 0.0534 no no no dn no up iso-LCA+blood Tuberculosis -0.482226233 0 0 serum_bileacids kegg 0.507 NA no no no no no dn iso-LCA+blood Type I diabetes mellitus 0 0 -0.408155916 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood Ubiquitin mediated proteolysis 0.547141303 0 0 serum_bileacids kegg 0.507 NA no no no no no no iso-LCA+blood UDCA+stool -0.601729673 -0.663341671 -0.584041363 serum_bileacids stool_bileacids 0.507 0.266 no no no no no no iso-LCA+stool 12-ketoDCA+stool 0 0.721542262 0.526679842 stool_bileacids stool_bileacids 0.72 0.505 no no no no no no iso-LCA+stool 4-hydroxybenzoic acid+stool 0 -0.727272727 0 stool_bileacids stool_cometabolism 0.72 0.0536 no no no no dn no iso-LCA+stool Allograft rejection 0 -0.709090909 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Alzheimer disease 0.486319115 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Amphetamine addiction 0.601961877 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Amyotrophic lateral sclerosis 0.6071245 0 -0.489553924 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Antigen processing and presentation 0 -0.727272727 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Autoimmune thyroid disease 0 -0.709090909 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Autophagy - animal 0 0 0.552795031 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Bacterial invasion of epithelial cells 0 -0.663636364 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Bacteroides -0.541042922 0 0 LPS-producing stool_bileacids Genus 0.72 0.000267 no no no dn dn up iso-LCA+stool Biosynthesis of amino acids -0.554465742 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool CA+stool -0.751677953 -0.657342657 -0.644268775 stool_bileacids stool_bileacids 0.72 0.827 no no no no no no iso-LCA+stool Carbon metabolism 0 -0.836363636 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Cardiac muscle contraction 0.481156492 0 -0.469226426 stool_bileacids kegg 0.72 NA no no no no no up iso-LCA+stool CDCA+stool -0.886938683 -0.594405594 -0.683794466 stool_bileacids stool_bileacids 0.72 0.663 no no no no no no iso-LCA+stool Cell adhesion molecules 0 -0.736363636 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Cellular senescence -0.600929352 -0.618181818 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Central carbon metabolism in cancer 0 0 0.557312253 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Chemical carcinogenesis - receptor activation 0 0.790909091 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Choline metabolism in cancer 0 0.609090909 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Circadian entrainment 0.478058918 0 0 stool_bileacids kegg 0.72 NA no no no no up up iso-LCA+stool Clostridium 0 -0.60090525 0 stool_bileacids Genus 0.72 0.925 no no no no no no iso-LCA+stool Cocaine addiction 0 0.736363636 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Coprococcus 0 0 0.495059289 butyrate-producing stool_bileacids Genus 0.72 0.612 no no no no no no iso-LCA+stool Cortisol synthesis and secretion 0 0.754545455 0 stool_bileacids kegg 0.72 NA no no no no no up iso-LCA+stool Cushing syndrome 0.486319115 0.790909091 0 stool_bileacids kegg 0.72 NA no no no no no up iso-LCA+stool DCA+stool 0.596799254 0.811188811 0.533596838 stool_bileacids stool_bileacids 0.72 0.195 no no no no no no iso-LCA+stool Diabetic cardiomyopathy 0.478058918 0 -0.505364201 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Dorea -0.534847774 0 0 stool_bileacids Genus 0.72 0.00362 no no no up no dn iso-LCA+stool Eggerthella 0 -0.591312396 0 stool_bileacids Genus 0.72 0.912 no no no no no no iso-LCA+stool Endocrine resistance 0 0.736363636 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Endocytosis -0.559628366 -0.763636364 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Epithelial cell signaling in Helicobacter pylori infection -0.610222074 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Epstein-Barr virus infection 0 -0.609090909 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Fluid shear stress and atherosclerosis 0 -0.763636364 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool FoxO signaling pathway -0.489416689 0 0.691699605 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool GABAergic synapse -0.597831778 0 0 stool_bileacids kegg 0.72 NA no no no no up up iso-LCA+stool Gastric acid secretion 0.491481738 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Gastric cancer 0 0 0.461321287 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool GCA+stool 0 -0.79020979 0 stool_bileacids stool_bileacids 0.72 0.0809 no no no no no no iso-LCA+stool GLCA+stool -0.655204588 0 0 stool_bileacids stool_bileacids 0.72 0.617 no no no no no no iso-LCA+stool GnRH signaling pathway 0 0.7 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Graft-versus-host disease 0 -0.709090909 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool "Growth hormone synthesis, secretion and action" 0 0.672727273 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool HCA+stool -0.671141029 0 -0.479249012 stool_bileacids stool_bileacids 0.72 0.155 no no no no no no iso-LCA+stool HDCA+stool 0.528652626 0.594405594 0.555335968 stool_bileacids stool_bileacids 0.72 0.176 no no no no no no iso-LCA+stool Hepatocellular carcinoma 0.472896294 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Herpes simplex virus 1 infection 0 -0.645454545 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Hippo signaling pathway 0.538977873 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Human cytomegalovirus infection 0 -0.636363636 0 stool_bileacids kegg 0.72 NA no no no no no dn iso-LCA+stool Human immunodeficiency virus 1 infection 0 -0.609090909 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Human papillomavirus infection -0.566856038 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Human T-cell leukemia virus 1 infection 0 -0.681818182 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Huntington disease 0.550335644 0 -0.453416149 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool IL-17 signaling pathway -0.585441482 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Insulin secretion 0 0.718181818 0 yes stool_bileacids kegg 0.72 NA no no no no up up iso-LCA+stool iso-DCA+stool 0.561693415 0 0 stool_bileacids stool_bileacids 0.72 0.155 no no no no no no iso-LCA+stool Leishmaniasis 0 -0.709090909 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Leukocyte transendothelial migration 0 -0.745454545 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Lipid and atherosclerosis -0.557563316 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool MAPK signaling pathway 0 0 0.50310559 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Melanogenesis 0.554465742 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Morphine addiction 0 0.736363636 0 stool_bileacids kegg 0.72 NA no no no no up up iso-LCA+stool Natural killer cell mediated cytotoxicity -0.475993868 -0.727272727 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Neuroactive ligand-receptor interaction 0 -0.681818182 0 stool_bileacids kegg 0.72 NA no no no up up up iso-LCA+stool Neutrophil extracellular trap formation -0.470831245 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool NF-kappa B signaling pathway -0.508002133 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool NOD-like receptor signaling pathway -0.540010397 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Non-alcoholic fatty liver disease 0 0 -0.466967815 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Odoribacter 0 -0.881118881 0 butyrate-producing stool_bileacids Genus 0.72 0.798 no no no no no no iso-LCA+stool Oscillospira 0.51626233 0 0 LPS-producing stool_bileacids Genus 0.72 0.62 no no no no no no iso-LCA+stool Osteoclast differentiation -0.490449214 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Oxidative phosphorylation 0.515229805 0 -0.501976285 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool p53 signaling pathway 0 0.772727273 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Pancreatic cancer 0 0 0.669113495 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Pathogenic Escherichia coli infection 0 -0.718181818 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Pathways in cancer 0 0.863636364 0.529079616 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Peroxisome -0.604026926 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Pertussis -0.574083711 0 0 stool_bileacids kegg 0.72 NA no no no no no dn iso-LCA+stool Phagosome 0 -0.736363636 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Platelet activation 0.483221541 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Platinum drug resistance 0 0 0.629587804 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Prion disease 0.505937083 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Proteasome 0 -0.663636364 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Renal cell carcinoma 0 0 0.628458498 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Renin secretion 0.472896294 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool RIG-I-like receptor signaling pathway -0.579246334 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Salmonella infection 0 -0.790909091 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Serotonergic synapse 0 0.609090909 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Signaling pathways regulating pluripotency of stem cells 0 0.681818182 0.476002259 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool T cell receptor signaling pathway 0 0 0.471485037 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Thermogenesis 0.66701093 0 -0.508752117 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Thyroid hormone signaling pathway 0.529685151 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Tight junction 0 -0.7 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Transcriptional misregulation in cancer -0.619514796 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Type I diabetes mellitus 0 -0.709090909 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Vibrio cholerae infection 0 0 -0.526821005 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Viral carcinogenesis -0.523490003 0 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Viral myocarditis 0 -0.727272727 0 stool_bileacids kegg 0.72 NA no no no no no no iso-LCA+stool Wnt signaling pathway 0.48735164 0 0 stool_bileacids kegg 0.72 NA no no no no no no isobutyric acid C4+blood 12-ketoDCA+blood -0.519474976 0 0 serum_scfa serum_bileacids 0.0151 0.517 up up no no no no isobutyric acid C4+blood 13-HODE+blood 0 0.625 0 serum_scfa serum_ARA 0.0151 0.32 up up no no no no isobutyric acid C4+blood 16:0/18:0-PC+blood 0 0 -0.42974359 serum_scfa serum_phospholipids 0.0151 0.521 up up no no no no isobutyric acid C4+blood 18:0-LPA+blood 0 0 0.428376068 serum_scfa serum_phospholipids 0.0151 0.0725 up up no no dn no isobutyric acid C4+blood 18:1/18:2-PI+blood -0.455639098 0 0 serum_scfa serum_phospholipids 0.0151 0.0164 up up no dn no up isobutyric acid C4+blood 18:2-LPC+blood 0 0.549019608 0 serum_scfa serum_phospholipids 0.0151 0.00743 up up no dn no up isobutyric acid C4+blood 18:3/18:2-PC+blood 0 0 -0.457094017 serum_scfa serum_phospholipids 0.0151 0.0394 up up no no no up isobutyric acid C4+blood 2-methyl-butyric acid m-C4+blood 0.639097744 0.639705882 0.807179487 serum_scfa serum_scfa 0.0151 0.262 up up no no no no isobutyric acid C4+blood 20:1+blood 0 0.612745098 0 yes serum_scfa serum_fattyacid 0.0151 2.56E-05 up up no dn dn dn isobutyric acid C4+blood 9-HODE+blood 0 0.75245098 0 serum_scfa serum_ARA 0.0151 0.297 up up no no no no isobutyric acid C4+blood acetic acid C2+blood 0.514285714 0 0 serum_scfa serum_scfa 0.0151 0.000193 up up no up dn no isobutyric acid C4+blood butyric acid C4+blood 0.581954887 0.661764706 0.60957265 serum_scfa serum_scfa 0.0151 0.407 up up no no no no isobutyric acid C4+blood CA+blood 0 0 -0.466212006 serum_scfa serum_bileacids 0.0151 0.606 up up no no no no isobutyric acid C4+blood DCA+blood -0.568421053 0 0 serum_scfa serum_bileacids 0.0151 0.122 up up no no no no isobutyric acid C4+blood decanoic acid C10+blood 0.494736842 0 0 serum_scfa serum_mcfa 0.0151 6.64E-11 up up no dn dn no isobutyric acid C4+blood heptanoic acid C7+blood 0.532330827 0 0.426324786 serum_scfa serum_mcfa 0.0151 8.27E-11 up up no dn dn no isobutyric acid C4+blood iso-LCA+blood 0 0.527690906 0 serum_scfa serum_bileacids 0.0151 0.507 up up no no no no Isobutyric acid+stool 4-hydroxybenzoic acid+stool 0 0 -0.523715415 stool_scfa stool_cometabolism 0.408 0.0536 no no no no dn no Isobutyric acid+stool CA+stool 0 -0.713286713 -0.558300395 stool_scfa stool_bileacids 0.408 0.827 no no no no no no Isobutyric acid+stool CDCA+stool -0.479876161 -0.909090909 -0.731225296 stool_scfa stool_bileacids 0.408 0.663 no no no no no no Isobutyric acid+stool GCA+stool -0.506707946 -0.678321678 0 stool_scfa stool_bileacids 0.408 0.0809 no no no no no no Isobutyric acid+stool GCDCA+stool -0.488132095 -0.93006993 0 yes stool_scfa stool_bileacids 0.408 0.0471 no no no no dn no Isobutyric acid+stool GDCA+stool 0 -0.76357385 0 stool_scfa stool_bileacids 0.408 0.656 no no no no no no Isobutyric acid+stool Indole-3-Acetic acid+stool 0.552115583 0.762237762 0.5256917 stool_scfa stool_cometabolism 0.408 0.304 no no no no no no Isobutyric acid+stool iso-LCA+stool 0.518327379 0 0 stool_scfa stool_bileacids 0.408 0.72 no no no no no no Isobutyric acid+stool ¦Ø-MCA+stool 0 -0.584849771 0 stool_scfa stool_bileacids 0.408 0.919 no no no no no no isocapric acid iso-C6+blood 12-ketoDCA+blood -0.561420161 0 0 serum_scfa serum_bileacids 0.0458 0.517 no no dn no no no isocapric acid iso-C6+blood 13-HODE+blood 0 0 -0.456410256 serum_scfa serum_ARA 0.0458 0.32 no no dn no no no isocapric acid iso-C6+blood 14:0/18:0-PC+blood -0.479699248 0 0 serum_scfa serum_phospholipids 0.0458 0.00289 no no dn up up no isocapric acid iso-C6+blood 14:1/18:2-PG+blood 0 -0.553921569 0 serum_scfa serum_phospholipids 0.0458 0.00259 no no dn no up up isocapric acid iso-C6+blood 15-HETE+blood 0 0.633797496 0 serum_scfa serum_ARA 0.0458 0.819 no no dn no no no isocapric acid iso-C6+blood 16:0-LPE+blood 0 0.610294118 0 serum_scfa serum_phospholipids 0.0458 0.0711 no no dn up up no isocapric acid iso-C6+blood 16:0/16:1-PC+blood -0.44962406 0 0 serum_scfa serum_phospholipids 0.0458 0.00283 no no dn up up no isocapric acid iso-C6+blood 16:0/20:3-PC+blood 0.469172932 0 0 serum_scfa serum_phospholipids 0.0458 5.43E-06 no no dn no up up isocapric acid iso-C6+blood 18:0/22:6-PI+blood 0 0 -0.518632479 serum_scfa serum_phospholipids 0.0458 0.425 no no dn no no no isocapric acid iso-C6+blood 18:3n3+blood 0 0.487745098 0 serum_scfa serum_fattyacid 0.0458 0.291 no no dn no no no isocapric acid iso-C6+blood 20:1-LPE+blood 0.521804511 0 0 serum_scfa serum_phospholipids 0.0458 0.465 no no dn no no no isocapric acid iso-C6+blood 20:5/18:0-PC+blood 0.45112782 0 0 serum_scfa serum_phospholipids 0.0458 3.97E-06 no no dn no up up isocapric acid iso-C6+blood 22:6n3+blood 0 0 -0.422905983 serum_scfa serum_fattyacid 0.0458 0.792 no no dn no no no isocapric acid iso-C6+blood CA+blood -0.47461455 0 0 serum_scfa serum_bileacids 0.0458 0.606 no no dn no no no isocapric acid iso-C6+blood d18:1-18:1-SM+blood 0 0 0.444786325 serum_scfa serum_phospholipids 0.0458 0.916 no no dn no no no isocapric acid iso-C6+blood d18:1-20:1-SM+blood 0 0 0.566495726 serum_scfa serum_phospholipids 0.0458 0.0992 no no dn no no no isocapric acid iso-C6+blood GCDCA+blood 0 -0.544117647 0 serum_scfa serum_bileacids 0.0458 0.31 no no dn no no no isocapric acid iso-C6+blood GDCA+blood 0 0 -0.444786325 serum_scfa serum_bileacids 0.0458 0.632 no no dn no no no isocapric acid iso-C6+blood HCA+blood -0.48842437 0 0 serum_scfa serum_bileacids 0.0458 0.544 no no dn no no no isovaleric acid iso-C5+blood 16:0/16:0-PI+blood 0 -0.490196078 0 serum_scfa serum_phospholipids 0.117 0.358 no no no no no no isovaleric acid iso-C5+blood 16:0/20:5-PG+blood 0 0.580882353 0 serum_scfa serum_phospholipids 0.117 0.00656 no no no no up no isovaleric acid iso-C5+blood 18:0/18:1-PG+blood -0.520300752 0 0 serum_scfa serum_phospholipids 0.117 0.000842 no no no no up no isovaleric acid iso-C5+blood 18:0/18:1-PI+blood -0.544360902 0 0 serum_scfa serum_phospholipids 0.117 0.599 no no no no no no isovaleric acid iso-C5+blood 18:0/20:2-PC+blood 0 -0.632352941 0 serum_scfa serum_phospholipids 0.117 0.733 no no no no no no isovaleric acid iso-C5+blood 18:0/20:3-PC+blood 0 -0.593137255 0 serum_scfa serum_phospholipids 0.117 0.0682 no no no no up no isovaleric acid iso-C5+blood 18:1/18:1-PC+blood 0 -0.507352941 0 serum_scfa serum_phospholipids 0.117 1.34E-05 no no no no up up isovaleric acid iso-C5+blood 18:1/20:3-PC+blood 0 -0.56127451 0 serum_scfa serum_phospholipids 0.117 0.00872 no no no no up up isovaleric acid iso-C5+blood 18:2/18:2-PS+blood 0 0 0.432478632 serum_scfa serum_phospholipids 0.117 0.00674 no no no up up no isovaleric acid iso-C5+blood 20:1+blood 0 0 0.435213675 yes serum_scfa serum_fattyacid 0.117 2.56E-05 no no no dn dn dn isovaleric acid iso-C5+blood 20:2/18:0-PC+blood 0 -0.571078431 0 serum_scfa serum_phospholipids 0.117 0.0427 no no no no up no isovaleric acid iso-C5+blood 20:4-LPC+blood 0 0.531862745 0 serum_scfa serum_phospholipids 0.117 0.949 no no no no no no isovaleric acid iso-C5+blood 20:5-LPC+blood 0 0.514705882 0 serum_scfa serum_phospholipids 0.117 0.558 no no no no no no isovaleric acid iso-C5+blood 22:6-LPC+blood 0 0.509803922 0 serum_scfa serum_phospholipids 0.117 0.127 no no no no no up isovaleric acid iso-C5+blood butyric acid C4+blood 0.479699248 0 0 serum_scfa serum_scfa 0.117 0.407 no no no no no no isovaleric acid iso-C5+blood Cysteine+blood 0 0 0.405128205 yes serum_scfa serum_aminoacids 0.117 1.81E-07 no no no dn up up isovaleric acid iso-C5+blood d18:0-16:0-SM+blood 0 0 0.459145299 serum_scfa serum_phospholipids 0.117 0.202 no no no no no no isovaleric acid iso-C5+blood d18:0-24:1-SM+blood 0 -0.490196078 0 serum_scfa serum_phospholipids 0.117 0.0609 no no no no dn dn isovaleric acid iso-C5+blood d18:1-16:0-SM+blood 0 0 0.42017094 serum_scfa serum_phospholipids 0.117 0.14 no no no no no no isovaleric acid iso-C5+blood decanoic acid C10+blood 0 -0.490196078 0 serum_scfa serum_mcfa 0.117 6.64E-11 no no no dn dn no isovaleric acid iso-C5+blood EPA+blood 0 0.590686275 0 serum_scfa serum_ARA 0.117 0.212 no no no no no no isovaleric acid iso-C5+blood GUDCA+blood 0 0 -0.406495726 serum_scfa serum_bileacids 0.117 0.0766 no no no no no dn isovaleric acid iso-C5+blood isobutyric acid C4+blood 0 0 0.474871795 serum_scfa serum_scfa 0.117 0.0151 no no no up up no Isovaleric acid+stool 4-hydroxybenzoic acid+stool -0.525283798 0 -0.564229249 stool_scfa stool_cometabolism 0.343 0.0536 no no no no dn no Isovaleric acid+stool Acetic acid+stool 0 0 -0.424901186 yes stool_scfa stool_scfa 0.343 0.0656 no no no dn no no Isovaleric acid+stool CA+stool 0 0 -0.567193676 stool_scfa stool_bileacids 0.343 0.827 no no no no no no Isovaleric acid+stool CDCA+stool -0.570691434 -0.804195804 -0.744071146 stool_scfa stool_bileacids 0.343 0.663 no no no no no no Isovaleric acid+stool GCA+stool -0.471620227 -0.58041958 0 stool_scfa stool_bileacids 0.343 0.0809 no no no no no no Isovaleric acid+stool GCDCA+stool -0.488132095 -0.972027972 0 yes stool_scfa stool_bileacids 0.343 0.0471 no no no no dn no Isovaleric acid+stool GDCA+stool 0 -0.626971189 0 stool_scfa stool_bileacids 0.343 0.656 no no no no no no Isovaleric acid+stool Indole-3-Acetic acid+stool 0.533539732 0.762237762 0.52173913 stool_scfa stool_cometabolism 0.343 0.304 no no no no no no Isovaleric acid+stool iso-LCA+stool 0.557563316 0 0 stool_scfa stool_bileacids 0.343 0.72 no no no no no no Isovaleric acid+stool Isobutyric acid+stool 0.900928793 0.93006993 0.984189723 stool_scfa stool_scfa 0.343 0.408 no no no no no no JAK-STAT signaling pathway ABC transporters 0.486086957 0.713438735 0.594337194 kegg kegg NA NA no no no no up up JAK-STAT signaling pathway Adherens junction 0 -0.78458498 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Adrenergic signaling in cardiomyocytes -0.406956522 -0.556324111 0 kegg kegg NA NA no no no no no up JAK-STAT signaling pathway "Alanine, aspartate and glutamate metabolism" 0.429565217 0.720355731 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway alpha-Linolenic acid metabolism 0 0.701581028 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Antigen processing and presentation 0 -0.415019763 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Apelin signaling pathway 0 -0.794466403 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Apoptosis 0 0.539525692 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Apoptosis - multiple species 0 0.677865613 0.51969112 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Arachidonic acid metabolism -0.413043478 0 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Arginine and proline metabolism 0 0.579051383 0 kegg kegg NA NA no no no no up no JAK-STAT signaling pathway Arginine biosynthesis 0.430434783 0.638339921 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Autophagy - animal 0.42173913 0.852766798 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Autophagy - other 0 0.622529644 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Butanoate metabolism 0 -0.570158103 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway C-type lectin receptor signaling pathway 0 0.636363636 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Calcium signaling pathway 0 -0.428853755 0 kegg kegg NA NA no no no no up up JAK-STAT signaling pathway Cardiac muscle contraction 0 -0.699604743 0 kegg kegg NA NA no no no no no up JAK-STAT signaling pathway Citrate cycle (TCA cycle) 0 -0.614624506 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Clostridium 0 -0.476800962 0 kegg Genus NA 0.925 no no no no no no JAK-STAT signaling pathway Cysteine and methionine metabolism 0 -0.65513834 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Cytosolic DNA-sensing pathway 0 0 -0.402574003 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway DNA replication 0 -0.416996047 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Drug metabolism - cytochrome P450 0 -0.654150198 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Drug metabolism - other enzymes 0 -0.787549407 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.67687747 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway ErbB signaling pathway 0 0.68083004 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Fatty acid biosynthesis 0.427826087 0.709486166 0.431402831 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Fatty acid degradation 0.431304348 0.630434783 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Fatty acid elongation 0 -0.497035573 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Fatty acid metabolism 0 0.48715415 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Focal adhesion 0 -0.767786561 0 kegg kegg NA NA no no no no up up JAK-STAT signaling pathway FoxO signaling pathway 0.705217391 0.896245059 0.708108108 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Fructose and mannose metabolism 0 0.698616601 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Galactose metabolism 0.420869565 0.720355731 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Glutathione metabolism -0.506956522 -0.650197628 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Glycerolipid metabolism 0.61826087 0.815217391 0 kegg kegg NA NA no no no no no up JAK-STAT signaling pathway Glycerophospholipid metabolism 0 0.675889328 0 kegg kegg NA NA no no no no no up JAK-STAT signaling pathway Glycolysis / Gluconeogenesis 0 -0.734189723 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.853754941 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.464426877 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.42 0 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.611660079 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway HIF-1 signaling pathway 0 -0.73715415 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Hippo signaling pathway 0 -0.722332016 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Hippo signaling pathway - multiple species 0 0.645256917 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Inositol phosphate metabolism 0.666956522 0.718379447 0.471814672 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Lachnospira 0.456521739 -0.548060308 0 butyrate-producing kegg Genus NA 0.279 no no no no no no JAK-STAT signaling pathway MAPK signaling pathway 0.606956522 0.615612648 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.674901186 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Mitophagy - animal -0.455652174 -0.472332016 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway mTOR signaling pathway 0 -0.678853755 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway N-Glycan biosynthesis 0 -0.5 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway NF-kappa B signaling pathway 0.516521739 0.84486166 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Nicotinate and nicotinamide metabolism 0.408695652 0.656126482 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Nitrogen metabolism 0 0.538537549 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway NOD-like receptor signaling pathway 0.454782609 0.707509881 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Non-homologous end-joining 0 -0.518774704 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Notch signaling pathway 0 0.583003953 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Oocyte meiosis 0 -0.690711462 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Oscillospira 0 0.518774704 0 LPS-producing kegg Genus NA 0.62 no no no no no no JAK-STAT signaling pathway Osteoclast differentiation 0.446956522 0.561264822 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Other glycan degradation 0 0.679841897 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Oxidative phosphorylation 0 -0.756916996 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway p53 signaling pathway 0 0.567193676 0.542342342 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Pantothenate and CoA biosynthesis 0.533043478 0.583003953 0 kegg kegg NA NA no no no no no dn JAK-STAT signaling pathway Pentose and glucuronate interconversions 0 -0.583003953 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Peroxisome 0 0.538537549 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Phenylalanine metabolism 0 -0.486166008 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Phospholipase D signaling pathway 0 0.7243083 0 kegg kegg NA NA no no no no up up JAK-STAT signaling pathway PI3K-Akt signaling pathway 0.422608696 0 0 yes kegg kegg NA NA no no no no up up JAK-STAT signaling pathway Platelet activation 0 -0.707509881 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Platinum drug resistance 0 0.60770751 0.513770914 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway PPAR signaling pathway 0 0.47826087 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Primary bile acid biosynthesis 0 -0.52173913 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Propanoate metabolism 0 -0.660079051 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Proteasome 0 -0.705533597 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Protein export 0 -0.781620553 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Protein processing in endoplasmic reticulum -0.430434783 -0.501976285 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Pyrimidine metabolism 0 0 0.503989704 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Pyruvate metabolism 0 -0.692687747 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Rap1 signaling pathway 0 -0.544466403 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Ras signaling pathway 0 -0.615612648 0 yes kegg kegg NA NA no no no no up up JAK-STAT signaling pathway Ribosome 0 -0.804347826 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway RIG-I-like receptor signaling pathway 0 0.783596838 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway RNA degradation 0 -0.514822134 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway RNA transport 0 -0.616600791 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Ruminococcus 0 -0.443785412 0 kegg Genus NA 0.0679 no no no no no dn JAK-STAT signaling pathway Selenocompound metabolism 0 0.423913043 0.502445302 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Signaling pathways regulating pluripotency of stem cells 0 0.455533597 0.436036036 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway SNARE interactions in vesicular transport 0 0.734189723 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Spliceosome 0 0.527667984 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Starch and sucrose metabolism 0.523478261 0.68083004 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Sulfur metabolism 0 -0.444664032 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Taurine and hypotaurine metabolism 0.503478261 0.793478261 0.43963964 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway TGF-beta signaling pathway 0 -0.785573123 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Thiamine metabolism 0 -0.615612648 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Tight junction 0 -0.798418972 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Toll-like receptor signaling pathway 0 0.613636364 0 yes kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Tryptophan metabolism 0 -0.486166008 0 kegg kegg NA NA no no no no up no JAK-STAT signaling pathway Tyrosine metabolism 0 -0.48715415 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Ubiquitin mediated proteolysis -0.492173913 -0.470355731 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway "Valine, leucine and isoleucine degradation" 0 -0.450592885 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Vascular smooth muscle contraction -0.531304348 -0.7756917 -0.544144144 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway VEGF signaling pathway 0 0.472332016 0 kegg kegg NA NA no no no no no no JAK-STAT signaling pathway Wnt signaling pathway 0 -0.456521739 0 kegg kegg NA NA no no no no no no Kaposi sarcoma-associated herpesvirus infection ABC transporters -0.442608696 0 0 kegg kegg NA NA no no dn no up up Kaposi sarcoma-associated herpesvirus infection Adipocytokine signaling pathway 0.759130435 0.483201581 0.634234234 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Adrenergic signaling in cardiomyocytes 0.54173913 0 0 kegg kegg NA NA no no dn no no up Kaposi sarcoma-associated herpesvirus infection Alcoholism 0 0 0.412612613 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Aldosterone synthesis and secretion 0.46173913 0 0 kegg kegg NA NA no no dn no up up Kaposi sarcoma-associated herpesvirus infection Aldosterone-regulated sodium reabsorption 0 0 -0.607207207 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection alpha-Linolenic acid metabolism 0 0 -0.531274131 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Alzheimer disease 0 0.454545455 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Amino sugar and nucleotide sugar metabolism -0.524347826 -0.519762846 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Aminoacyl-tRNA biosynthesis -0.484347826 -0.446640316 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection AMPK signaling pathway 0.44 0 0.571943372 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Antifolate resistance 0 -0.580039526 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Antigen processing and presentation 0 0.431818182 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Arachidonic acid metabolism 0 0 0.427541828 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Ascorbate and aldarate metabolism -0.584347826 0 -0.545688546 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Autophagy - animal 0 0 -0.402831403 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Axon guidance 0.414782609 0 0 kegg kegg NA NA no no dn no up up Kaposi sarcoma-associated herpesvirus infection Base excision repair 0 -0.503952569 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection beta-Alanine metabolism -0.591304348 -0.486166008 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Bile secretion 0.492173913 0 0.501930502 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Biosynthesis of cofactors 0 0 0.509395109 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Biosynthesis of unsaturated fatty acids -0.752173913 0 -0.407207207 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Butanoate metabolism -0.473043478 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Calcium signaling pathway 0.462608696 0 0 kegg kegg NA NA no no dn no up up Kaposi sarcoma-associated herpesvirus infection cAMP signaling pathway 0.526956522 0.555335968 0 yes kegg kegg NA NA no no dn no up up Kaposi sarcoma-associated herpesvirus infection Carbohydrate digestion and absorption 0 0 -0.622908623 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Cardiac muscle contraction 0 0.418972332 0 kegg kegg NA NA no no dn no no up Kaposi sarcoma-associated herpesvirus infection Chagas disease 0.471304348 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Cholesterol metabolism 0.428695652 0 0 yes kegg kegg NA NA no no dn no no up Kaposi sarcoma-associated herpesvirus infection Cholinergic synapse 0 -0.538537549 -0.505534106 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Citrate cycle (TCA cycle) -0.599130435 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Cocaine addiction 0.670434783 0 0.5003861 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Cortisol synthesis and secretion 0.58 0 0 kegg kegg NA NA no no dn no no up Kaposi sarcoma-associated herpesvirus infection Cushing syndrome 0.437391304 0 0 kegg kegg NA NA no no dn no no up Kaposi sarcoma-associated herpesvirus infection Cysteine and methionine metabolism -0.423478261 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Cytosolic DNA-sensing pathway 0.513043478 0.584980237 0.466409266 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection DNA replication -0.548695652 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Dopaminergic synapse 0.47826087 0 0 kegg kegg NA NA no no dn no up no Kaposi sarcoma-associated herpesvirus infection Drug metabolism - other enzymes -0.444347826 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection ECM-receptor interaction 0 -0.425889328 0 kegg kegg NA NA no no dn no up up Kaposi sarcoma-associated herpesvirus infection ErbB signaling pathway 0 0 -0.564221364 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Estrogen signaling pathway -0.413043478 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Fanconi anemia pathway -0.545217391 -0.420948617 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Fatty acid degradation -0.650434783 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Fatty acid elongation -0.675652174 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Fatty acid metabolism -0.677391304 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Fc epsilon RI signaling pathway 0 0 -0.442728443 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Fc gamma R-mediated phagocytosis -0.607826087 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Ferroptosis 0.616521739 0.616600791 0.748519949 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection FoxO signaling pathway 0 0 -0.501158301 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Galactose metabolism -0.548695652 -0.469367589 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Glutathione metabolism 0 0 0.563706564 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Glycerolipid metabolism 0 0 -0.474646075 kegg kegg NA NA no no dn no no up Kaposi sarcoma-associated herpesvirus infection Glycerophospholipid metabolism 0 0 -0.492664093 kegg kegg NA NA no no dn no no up Kaposi sarcoma-associated herpesvirus infection "Glycine, serine and threonine metabolism" 0 0 0.527927928 kegg kegg NA NA no no dn no up no Kaposi sarcoma-associated herpesvirus infection Glycolysis / Gluconeogenesis -0.429565217 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.496047431 -0.437065637 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Glycosaminoglycan degradation 0 0 -0.458172458 kegg kegg NA NA no no dn no no up Kaposi sarcoma-associated herpesvirus infection Glycosphingolipid biosynthesis - ganglio series 0 -0.461462451 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection GnRH secretion 0 0 -0.55006435 kegg kegg NA NA no no dn no up up Kaposi sarcoma-associated herpesvirus infection GnRH signaling pathway 0.512173913 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Hedgehog signaling pathway 0 -0.475296443 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Hematopoietic cell lineage -0.446086957 -0.476284585 -0.4002574 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Hepatitis C 0 0.459486166 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Hippo signaling pathway - multiple species 0 0 -0.55032175 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Histidine metabolism -0.680869565 -0.48715415 -0.532561133 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Homologous recombination -0.546956522 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Human cytomegalovirus infection 0 0.529644269 0 kegg kegg NA NA no no dn no no dn Kaposi sarcoma-associated herpesvirus infection Human T-cell leukemia virus 1 infection 0 0.496047431 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Huntington disease 0 0.471343874 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Inositol phosphate metabolism -0.513043478 -0.480237154 -0.62985843 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Insulin secretion 0.496521739 0 0 yes kegg kegg NA NA no no dn no up up Kaposi sarcoma-associated herpesvirus infection Long-term depression 0.551304348 0.453557312 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Longevity regulating pathway 0.575652174 0 0.567567568 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Longevity regulating pathway - multiple species -0.70173913 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Lysine degradation 0 0 -0.407722008 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Malaria 0.452173913 0.690711462 0.835006435 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Mannose type O-glycan biosynthesis 0.449565217 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection MAPK signaling pathway -0.497391304 -0.602766798 -0.483397683 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Mineral absorption 0.722608696 0.638339921 0.767567568 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Mismatch repair -0.72 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Mitophagy - animal 0.812173913 0.616600791 0.87953668 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Morphine addiction 0.56 0 0 kegg kegg NA NA no no dn no up up Kaposi sarcoma-associated herpesvirus infection Mucin type O-glycan biosynthesis -0.46 -0.477272727 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Necroptosis 0.646956522 0.712450593 0.738223938 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Neuroactive ligand-receptor interaction -0.493913043 0 0 kegg kegg NA NA no no dn up up up Kaposi sarcoma-associated herpesvirus infection Neurotrophin signaling pathway 0.550434783 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Non-alcoholic fatty liver disease 0.407826087 0.574110672 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Non-homologous end-joining -0.58 -0.434782609 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Notch signaling pathway 0 0 -0.534105534 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Nucleotide excision repair -0.588695652 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Olfactory transduction -0.53826087 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection One carbon pool by folate -0.569565217 -0.502964427 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Other glycan degradation 0 0 -0.5997426 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Other types of O-glycan biosynthesis 0 0 -0.500643501 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Ovarian steroidogenesis 0 0 0.431917632 kegg kegg NA NA no no dn no up up Kaposi sarcoma-associated herpesvirus infection Oxidative phosphorylation 0 0.445652174 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Pancreatic secretion 0.572173913 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Pantothenate and CoA biosynthesis -0.480869565 0 0 kegg kegg NA NA no no dn no no dn Kaposi sarcoma-associated herpesvirus infection "Parathyroid hormone synthesis, secretion and action" 0.664347826 0.479249012 0.471042471 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Parkinson disease 0.675652174 0.553359684 0.760617761 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Pathways of neurodegeneration - multiple diseases 0.671304348 0.545454545 0.764736165 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Pentose and glucuronate interconversions -0.532173913 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Peroxisome -0.539130435 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Phenylalanine metabolism -0.431304348 -0.460474308 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Phosphatidylinositol signaling system 0 -0.510869565 -0.51016731 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Platinum drug resistance 0 -0.461462451 -0.479021879 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Porphyrin and chlorophyll metabolism 0 0 0.605920206 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Primary bile acid biosynthesis -0.788695652 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Progesterone-mediated oocyte maturation 0 -0.434782609 -0.605662806 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Propanoate metabolism -0.47826087 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Protein digestion and absorption -0.513043478 0 -0.479279279 yes kegg kegg NA NA no no dn no up up Kaposi sarcoma-associated herpesvirus infection Protein processing in endoplasmic reticulum 0 0 0.557014157 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Purine metabolism 0 0 0.715315315 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Pyrimidine metabolism -0.555652174 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Pyruvate metabolism -0.60173913 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Ras signaling pathway 0 0 -0.416216216 yes kegg kegg NA NA no no dn no up up Kaposi sarcoma-associated herpesvirus infection Regulation of lipolysis in adipocytes 0.431304348 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Relaxin signaling pathway 0.775652174 0.423913043 0.427284427 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Retinol metabolism -0.690434783 -0.632411067 -0.534105534 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Ribosome 0.535652174 0.429841897 0.477477477 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Salmonella infection -0.455652174 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Selenocompound metabolism 0 -0.529644269 -0.515572716 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Shigellosis 0.793913043 0.783596838 0.896010296 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Signaling pathways regulating pluripotency of stem cells 0 0 -0.453281853 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Sphingolipid metabolism 0 0 -0.476705277 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Sphingolipid signaling pathway 0 0 -0.723552124 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Staphylococcus aureus infection -0.437391304 0 0 kegg kegg NA NA no no dn up no no Kaposi sarcoma-associated herpesvirus infection Steroid hormone biosynthesis -0.572173913 -0.581027668 -0.465637066 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Sulfur metabolism 0 0 0.486229086 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Synthesis and degradation of ketone bodies -0.651304348 -0.446640316 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Taste transduction -0.44173913 0 -0.50965251 kegg kegg NA NA no no dn no no up Kaposi sarcoma-associated herpesvirus infection Terpenoid backbone biosynthesis -0.437391304 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection TGF-beta signaling pathway 0 0 -0.492921493 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Thyroid hormone synthesis 0.50173913 0 0.574774775 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection TNF signaling pathway 0.588695652 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Toxoplasmosis -0.500869565 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Tryptophan metabolism -0.675652174 -0.488142292 0 kegg kegg NA NA no no dn no up no Kaposi sarcoma-associated herpesvirus infection Tuberculosis -0.500869565 0 0 kegg kegg NA NA no no dn no no dn Kaposi sarcoma-associated herpesvirus infection Type II diabetes mellitus 0 0 -0.543886744 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Tyrosine metabolism -0.612173913 -0.436758893 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Ubiquinone and other terpenoid-quinone biosynthesis -0.713043478 -0.580039526 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Ubiquitin mediated proteolysis 0.74 0.516798419 0.863835264 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection "Valine, leucine and isoleucine degradation" -0.655652174 -0.481225296 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Various types of N-glycan biosynthesis 0 0 -0.488030888 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Vascular smooth muscle contraction 0.553043478 0 0 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection VEGF signaling pathway 0 0 -0.546460746 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Vitamin digestion and absorption 0 -0.5 -0.462033462 kegg kegg NA NA no no dn no no no Kaposi sarcoma-associated herpesvirus infection Wnt signaling pathway 0 0 -0.428056628 kegg kegg NA NA no no dn no no no Kynurenic acid+stool 5-Hydroxytryptamine+stool 0 0.594405594 0 stool_cometabolism stool_cometabolism 0.037 0.00862 dn dn no dn dn no Kynurenic acid+stool ACA+stool 0 -0.650443636 0 stool_cometabolism stool_bileacids 0.037 0.417 dn dn no no no no Kynurenic acid+stool CA+stool 0 0 -0.537549407 stool_cometabolism stool_bileacids 0.037 0.827 dn dn no no no no Kynurenic acid+stool Indole-3-Acetic acid+stool 0 0.608391608 0 stool_cometabolism stool_cometabolism 0.037 0.304 dn dn no no no no Kynurenic acid+urine 2-hydroxyphenylacetic acid+urine 0 0 -0.409230769 urine_cometabolism urine_cometabolism 0.296 0.763 no no no no no no Kynurenic acid+urine 4-Hydroxyphenylacetic acid+urine 0 -0.473684211 -0.443418803 urine_cometabolism urine_cometabolism 0.296 0.0321 no no no up up no Kynurenic acid+urine 5-Hydroxyindole-3-acetic Acid+urine 0 0.670175439 0.514529915 urine_cometabolism urine_cometabolism 0.296 0.0405 no no no no dn dn Kynurenic acid+urine DL-Indole-3-lactic acid+urine 0 0 -0.402393162 urine_cometabolism urine_cometabolism 0.296 0.00552 no no no up up no L-2-Aminobutyric acid+blood 14:0-LPC+blood -0.482706767 -0.539215686 0 yes serum_aminoacids serum_phospholipids 0.000328 0.00689 up up no up up no L-2-Aminobutyric acid+blood 14:0/18:0-PC+blood 0 -0.50245098 0 yes serum_aminoacids serum_phospholipids 0.000328 0.00289 up up no up up no L-2-Aminobutyric acid+blood 14:1/18:2-PG+blood 0 -0.526960784 0 yes serum_aminoacids serum_phospholipids 0.000328 0.00259 up up no no up up L-2-Aminobutyric acid+blood 16:0-LPE+blood 0 0 -0.446153846 yes serum_aminoacids serum_phospholipids 0.000328 0.0711 up up no up up no L-2-Aminobutyric acid+blood 16:0/16:0-PI+blood 0 -0.487745098 0 yes serum_aminoacids serum_phospholipids 0.000328 0.358 up up no no no no L-2-Aminobutyric acid+blood 16:0/16:1-PI+blood -0.604511278 -0.49754902 0 yes serum_aminoacids serum_phospholipids 0.000328 0.262 up up no no no no L-2-Aminobutyric acid+blood 16:0/18:1-PE+blood 0 0 -0.473504274 yes serum_aminoacids serum_phospholipids 0.000328 0.000107 up up no up up no L-2-Aminobutyric acid+blood 16:0/18:2-PI+blood -0.54887218 -0.779411765 0 yes serum_aminoacids serum_phospholipids 0.000328 0.269 up up no no no no L-2-Aminobutyric acid+blood 16:0/20:4-PC+blood 0 0.715686275 0 yes serum_aminoacids serum_phospholipids 0.000328 0.0262 up up no no up no L-2-Aminobutyric acid+blood 16:0/20:4-PI+blood -0.458646617 -0.588235294 0 yes serum_aminoacids serum_phospholipids 0.000328 0.558 up up no no no no L-2-Aminobutyric acid+blood 16:0/22:0-PE+blood 0.464661654 0 0 yes serum_aminoacids serum_phospholipids 0.000328 0.00839 up up no dn no up L-2-Aminobutyric acid+blood 16:0/22:6-PC+blood 0.54887218 0.602941176 0 yes serum_aminoacids serum_phospholipids 0.000328 4.53E-05 up up no no up up L-2-Aminobutyric acid+blood 16:0/22:6-PE+blood 0 0 -0.417435897 yes serum_aminoacids serum_phospholipids 0.000328 0.000934 up up no up up no L-2-Aminobutyric acid+blood 16:1/16:0-PC+blood 0 0.492647059 0 yes serum_aminoacids serum_phospholipids 0.000328 0.0215 up up no no up up L-2-Aminobutyric acid+blood 16:1/16:1-PC+blood 0 0.492647059 0 yes serum_aminoacids serum_phospholipids 0.000328 0.0177 up up no no no up L-2-Aminobutyric acid+blood 18:0/18:0-PC+blood 0 0 0.549401709 yes serum_aminoacids serum_phospholipids 0.000328 0.426 up up no no no no L-2-Aminobutyric acid+blood 18:0/18:1-PC+blood 0 0 0.537777778 yes serum_aminoacids serum_phospholipids 0.000328 0.393 up up no no no no L-2-Aminobutyric acid+blood 18:0/20:2-PC+blood 0 -0.531862745 0 yes serum_aminoacids serum_phospholipids 0.000328 0.733 up up no no no no L-2-Aminobutyric acid+blood 18:0/20:4-PC+blood 0 0.580882353 0 yes serum_aminoacids serum_phospholipids 0.000328 0.454 up up no no no no L-2-Aminobutyric acid+blood 18:0/20:5-PC+blood 0.509774436 0.551470588 0 yes serum_aminoacids serum_phospholipids 0.000328 0.17 up up no no no no L-2-Aminobutyric acid+blood 18:0/22:6-PE+blood 0 0 -0.470769231 yes serum_aminoacids serum_phospholipids 0.000328 0.00022 up up no up up no L-2-Aminobutyric acid+blood 18:1/16:0-PE+blood -0.461654135 0 -0.452307692 yes serum_aminoacids serum_phospholipids 0.000328 0.000182 up up no up up no L-2-Aminobutyric acid+blood 18:1/16:1-PE+blood 0 -0.522058824 0 yes serum_aminoacids serum_phospholipids 0.000328 0.000184 up up no up up no L-2-Aminobutyric acid+blood 18:1/18:0-PE+blood 0 -0.625 -0.455726496 yes serum_aminoacids serum_phospholipids 0.000328 1.39E-06 up up no up up no L-2-Aminobutyric acid+blood 18:1/18:1-PE+blood 0 -0.566176471 0 yes serum_aminoacids serum_phospholipids 0.000328 1.03E-05 up up no up up no L-2-Aminobutyric acid+blood 18:1/18:2-PE+blood 0 -0.666666667 0 yes serum_aminoacids serum_phospholipids 0.000328 0.000293 up up no up up no L-2-Aminobutyric acid+blood 18:1/20:4-PC+blood 0.473684211 0 0 yes serum_aminoacids serum_phospholipids 0.000328 0.582 up up no no no no L-2-Aminobutyric acid+blood 18:3/16:0-PE+blood 0 -0.495098039 -0.414700855 yes serum_aminoacids serum_phospholipids 0.000328 0.00149 up up no up up no L-2-Aminobutyric acid+blood 18:3n3+blood 0 0.56127451 0 yes serum_aminoacids serum_fattyacid 0.000328 0.291 up up no no no no L-2-Aminobutyric acid+blood 18:3n6+blood -0.514285714 0 0 yes serum_aminoacids serum_fattyacid 0.000328 0.0463 up up no up no dn L-2-Aminobutyric acid+blood 20:0-LPE+blood -0.55037594 -0.482843137 0 yes serum_aminoacids serum_phospholipids 0.000328 0.0615 up up no no no up L-2-Aminobutyric acid+blood 20:0/20:4-PE+blood 0 -0.715686275 0 yes serum_aminoacids serum_phospholipids 0.000328 0.00128 up up no up up no L-2-Aminobutyric acid+blood 20:0/20:5-PC+blood 0.476691729 0 0 yes serum_aminoacids serum_phospholipids 0.000328 0.882 up up no no no no L-2-Aminobutyric acid+blood 20:2/18:1-PE+blood 0 -0.637254902 0 yes serum_aminoacids serum_phospholipids 0.000328 0.00208 up up no up up no L-2-Aminobutyric acid+blood 20:3/16:0-PC+blood 0 0.691176471 0 yes serum_aminoacids serum_phospholipids 0.000328 0.00405 up up no no up up L-2-Aminobutyric acid+blood 20:3/18:0-PC+blood 0 0.482843137 0 yes serum_aminoacids serum_phospholipids 0.000328 0.296 up up no no no no L-2-Aminobutyric acid+blood 20:4-LPC+blood 0 0.539215686 0 yes serum_aminoacids serum_phospholipids 0.000328 0.949 up up no no no no L-2-Aminobutyric acid+blood 20:4/16:0-PE+blood 0 0 -0.40034188 yes serum_aminoacids serum_phospholipids 0.000328 0.00529 up up no no up up L-2-Aminobutyric acid+blood 20:5/18:0-PC+blood 0.565413534 0.612745098 0 yes serum_aminoacids serum_phospholipids 0.000328 3.97E-06 up up no no up up L-2-Aminobutyric acid+blood 22:0/16:0-PE+blood 0.544360902 0 0 yes serum_aminoacids serum_phospholipids 0.000328 0.091 up up no no no up L-2-Aminobutyric acid+blood 22:6-LPC+blood 0 0.68872549 0 yes serum_aminoacids serum_phospholipids 0.000328 0.127 up up no no no up L-2-Aminobutyric acid+blood 5-HETE+blood 0.541135928 0 0 yes serum_aminoacids serum_ARA 0.000328 0.697 up up no no no no L-2-Aminobutyric acid+blood AA+blood 0 0.806372549 0 yes serum_aminoacids serum_ARA 0.000328 0.212 up up no no no no L-2-Aminobutyric acid+blood acetic acid C2+blood 0.45112782 0 0 yes serum_aminoacids serum_scfa 0.000328 0.000193 up up no up dn no L-2-Aminobutyric acid+blood Amoebiasis 0.526315789 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood Anaerostipes 0 0.528252371 0 yes butyrate-producing serum_aminoacids Genus 0.000328 0.568 up up no no no no L-2-Aminobutyric acid+blood Apelin signaling pathway -0.498245614 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood Axon guidance 0 -0.8 0 yes serum_aminoacids kegg 0.000328 NA up up no no up up L-2-Aminobutyric acid+blood Biosynthesis of cofactors -0.547368421 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood CDCA+blood -0.445112782 0 0 yes serum_aminoacids serum_bileacids 0.000328 0.506 up up no no no no L-2-Aminobutyric acid+blood Cell adhesion molecules 0 0 -0.405384615 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood Creatinine+blood 0.467669173 0 0 yes serum_aminoacids serum_choline 0.000328 0.437 up up no no no no L-2-Aminobutyric acid+blood Cysteine+blood 0 0 0.501538462 yes yes serum_aminoacids serum_aminoacids 0.000328 1.81E-07 up up no dn up up L-2-Aminobutyric acid+blood Cystine+blood 0 0 0.568547009 yes yes serum_aminoacids serum_aminoacids 0.000328 0.00028 up up no up up no L-2-Aminobutyric acid+blood DHA+blood 0 0.838235294 -0.496752137 yes serum_aminoacids serum_ARA 0.000328 0.872 up up no no no no L-2-Aminobutyric acid+blood Dilated cardiomyopathy 0 0 -0.42 yes serum_aminoacids kegg 0.000328 NA up up no no up up L-2-Aminobutyric acid+blood EGFR tyrosine kinase inhibitor resistance -0.603508772 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood EPA+blood 0 0.605392157 0 yes serum_aminoacids serum_ARA 0.000328 0.212 up up no no no no L-2-Aminobutyric acid+blood Fc epsilon RI signaling pathway 0.492982456 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood GCA+stool 0 0 0.533834586 yes serum_aminoacids stool_bileacids 0.000328 0.0809 up up no no no no L-2-Aminobutyric acid+blood "Glycine, serine and threonine metabolism" -0.49122807 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no up no L-2-Aminobutyric acid+blood HCA+blood -0.499853957 0 0 yes serum_aminoacids serum_bileacids 0.000328 0.544 up up no no no no L-2-Aminobutyric acid+blood HDCA+stool 0 0.636363636 0 yes serum_aminoacids stool_bileacids 0.000328 0.176 up up no no no no L-2-Aminobutyric acid+blood HIF-1 signaling pathway -0.585964912 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood Human papillomavirus infection 0 0 -0.448461538 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood IL-17 signaling pathway 0.549122807 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood Insulin signaling pathway -0.540350877 0 0.438461538 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood isocapric acid iso-C6+blood 0.592481203 0 0 yes serum_aminoacids serum_scfa 0.000328 0.0458 up up no no no dn L-2-Aminobutyric acid+blood L-Tryptophan+stool 0.571428571 0 0 yes serum_aminoacids stool_cometabolism 0.000328 0.557 up up no no no no L-2-Aminobutyric acid+blood Legionellosis -0.561403509 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood Lysosome 0.575438596 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood Measles 0 0.508823529 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood Methanobrevibacter 0 0 0.403322424 yes serum_aminoacids Genus 0.000328 0.629 up up no no no no L-2-Aminobutyric acid+blood mTOR signaling pathway -0.614035088 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood Odoribacter 0 0 -0.412119208 yes butyrate-producing serum_aminoacids Genus 0.000328 0.798 up up no no no no L-2-Aminobutyric acid+blood Phospholipase D signaling pathway 0.471929825 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no up up L-2-Aminobutyric acid+blood PI3K-Akt signaling pathway -0.60877193 0 0 yes yes serum_aminoacids kegg 0.000328 NA up up no no up up L-2-Aminobutyric acid+blood Porphyrin and chlorophyll metabolism -0.494736842 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood Primary immunodeficiency 0 0.520588235 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood Proteoglycans in cancer -0.698245614 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood Ribosome biogenesis in eukaryotes -0.466666667 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood RNA transport -0.635087719 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood Sphingolipid signaling pathway 0.464912281 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood Th1 and Th2 cell differentiation 0 0 0.403846154 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-2-Aminobutyric acid+blood total_stool_scfa+stool -0.582417582 0 0 yes serum_aminoacids stool_scfa 0.000328 0.0534 up up no dn no up L-2-Aminobutyric acid+blood Tuberculosis 0.478947368 0 0 yes serum_aminoacids kegg 0.000328 NA up up no no no dn L-2-Aminobutyric acid+blood Viral myocarditis 0 0 -0.403076923 yes serum_aminoacids kegg 0.000328 NA up up no no no no L-Alanine+blood 12-HEPE+blood 0.445082418 -0.556547714 0 yes serum_aminoacids serum_ARA 0.00138 0.312 up up no no no no L-Alanine+blood 12-ketoDCA+stool 0 0 -0.508270677 yes serum_aminoacids stool_bileacids 0.00138 0.505 up up no no no no L-Alanine+blood 14:0-LPC+blood 0 0 0.462564103 yes serum_aminoacids serum_phospholipids 0.00138 0.00689 up up no up up no L-Alanine+blood 14:0/16:0-PC+blood 0 0 0.405811966 yes serum_aminoacids serum_phospholipids 0.00138 0.0358 up up no no up no L-Alanine+blood 14:0/18:0-PC+blood 0 0 0.40034188 yes serum_aminoacids serum_phospholipids 0.00138 0.00289 up up no up up no L-Alanine+blood 14:0/20:4-PC+blood -0.506766917 0 0 yes serum_aminoacids serum_phospholipids 0.00138 0.486 up up no no no no L-Alanine+blood 16:0/16:0-PI+blood 0 0 0.43042735 yes serum_aminoacids serum_phospholipids 0.00138 0.358 up up no no no no L-Alanine+blood 16:0/16:1-PI+blood 0 0 0.591111111 yes serum_aminoacids serum_phospholipids 0.00138 0.262 up up no no no no L-Alanine+blood 16:0/18:2-PI+blood 0 0 0.602051282 yes serum_aminoacids serum_phospholipids 0.00138 0.269 up up no no no no L-Alanine+blood 16:0/18:3-PC+blood 0 0 0.591111111 yes serum_aminoacids serum_phospholipids 0.00138 0.00216 up up no no up up L-Alanine+blood 16:0/20:4-PI+blood 0 0 0.58017094 yes serum_aminoacids serum_phospholipids 0.00138 0.558 up up no no no no L-Alanine+blood 16:1-LPC+blood 0 0 0.447521368 yes serum_aminoacids serum_phospholipids 0.00138 0.0241 up up no no up no L-Alanine+blood 18:0/18:0-PS+blood -0.452631579 0 0 yes serum_aminoacids serum_phospholipids 0.00138 0.00617 up up no no up no L-Alanine+blood 18:0/18:1-PC+blood 0 0 0.414700855 yes serum_aminoacids serum_phospholipids 0.00138 0.393 up up no no no no L-Alanine+blood 18:0/18:2-PI+blood 0 0 0.597264957 yes serum_aminoacids serum_phospholipids 0.00138 0.179 up up no no no no L-Alanine+blood 18:0/20:3-PC+blood -0.485714286 0 0.465299145 yes serum_aminoacids serum_phospholipids 0.00138 0.0682 up up no no up no L-Alanine+blood 18:0/22:6-PA+blood -0.544360902 -0.49754902 0 yes serum_aminoacids serum_phospholipids 0.00138 0.22 up up no no no no L-Alanine+blood 18:1/16:0-PI+blood 0 0 0.528888889 yes serum_aminoacids serum_phospholipids 0.00138 0.793 up up no no no no L-Alanine+blood 18:1/18:0-PI+blood 0 -0.509803922 0.552136752 yes serum_aminoacids serum_phospholipids 0.00138 0.0931 up up no no no up L-Alanine+blood 18:1/18:0-PS+blood -0.661654135 0 0 yes serum_aminoacids serum_phospholipids 0.00138 0.193 up up no no no no L-Alanine+blood 18:1/22:6-PE+blood 0 0 -0.568547009 yes serum_aminoacids serum_phospholipids 0.00138 0.0047 up up no no up no L-Alanine+blood 18:2/18:2-PS+blood -0.484210526 0 0 yes serum_aminoacids serum_phospholipids 0.00138 0.00674 up up no up up no L-Alanine+blood 18:3n6+blood 0 0 0.485128205 yes serum_aminoacids serum_fattyacid 0.00138 0.0463 up up no up no dn L-Alanine+blood 20:0-LPE+blood 0 -0.549019608 0 yes serum_aminoacids serum_phospholipids 0.00138 0.0615 up up no no no up L-Alanine+blood 20:0+blood 0 -0.482843137 0.446837607 yes yes serum_aminoacids serum_fattyacid 0.00138 0.000278 up up no dn no up L-Alanine+blood 20:2-LPE+blood 0 -0.566176471 0 yes serum_aminoacids serum_phospholipids 0.00138 0.177 up up no no no no L-Alanine+blood 20:2/18:0-PC+blood -0.478195489 0 0.455726496 yes serum_aminoacids serum_phospholipids 0.00138 0.0427 up up no no up no L-Alanine+blood 20:3-LPC+blood 0 0 0.448205128 yes serum_aminoacids serum_phospholipids 0.00138 0.0292 up up no no up no L-Alanine+blood 22:2-LPA+blood 0 0 0.42974359 yes serum_aminoacids serum_phospholipids 0.00138 0.0443 up up no dn no no L-Alanine+blood acetic acid C2+blood 0 0 -0.437264957 yes serum_aminoacids serum_scfa 0.00138 0.000193 up up no up dn no L-Alanine+blood Adipocytokine signaling pathway 0.475438596 0 0 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Akkermansia 0 0 -0.482162677 yes acetate-producing serum_aminoacids Genus 0.00138 0.23 up up no no no no L-Alanine+blood Biosynthesis of amino acids 0 0 -0.434615385 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Calcium signaling pathway 0 0 0.493846154 yes serum_aminoacids kegg 0.00138 NA up up no no up up L-Alanine+blood capric acid C6+blood 0 0 -0.615726496 yes serum_aminoacids serum_scfa 0.00138 0.433 up up no no no no L-Alanine+blood Carbon metabolism 0 0 -0.516153846 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Cell cycle -0.494736842 0 0 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Chronic myeloid leukemia 0 0 0.415384615 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Circadian entrainment 0 0.520588235 0 yes serum_aminoacids kegg 0.00138 NA up up no no up up L-Alanine+blood Cocaine addiction 0 0 0.439230769 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Cortisol synthesis and secretion 0 0 0.429230769 yes serum_aminoacids kegg 0.00138 NA up up no no no up L-Alanine+blood Creatinine+blood 0 0 -0.491282051 yes serum_aminoacids serum_choline 0.00138 0.437 up up no no no no L-Alanine+blood Cushing syndrome 0 0 0.469230769 yes serum_aminoacids kegg 0.00138 NA up up no no no up L-Alanine+blood Cystine+blood 0.547368421 0.575980392 0 yes yes serum_aminoacids serum_aminoacids 0.00138 0.00028 up up no up up no L-Alanine+blood Cytosolic DNA-sensing pathway 0 0 0.412307692 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood d18:0-16:0-SM+blood 0 0 0.445470085 yes serum_aminoacids serum_phospholipids 0.00138 0.202 up up no no no no L-Alanine+blood d18:0-24:1-SM+blood 0 0 0.458461538 yes serum_aminoacids serum_phospholipids 0.00138 0.0609 up up no no dn dn L-Alanine+blood d18:1-14:1-SM+blood -0.506766917 0 0 yes serum_aminoacids serum_phospholipids 0.00138 0.0952 up up no no dn no L-Alanine+blood d18:1-16:0-SM+blood 0 0 0.444102564 yes serum_aminoacids serum_phospholipids 0.00138 0.14 up up no no no no L-Alanine+blood d18:1-20:0-SM+blood -0.481203008 0 0 yes serum_aminoacids serum_phospholipids 0.00138 0.933 up up no no no no L-Alanine+blood d18:1-20:1-SM+blood -0.463157895 0 0 yes serum_aminoacids serum_phospholipids 0.00138 0.0992 up up no no no no L-Alanine+blood d18:1-22:1-SM+blood 0 0 0.433162393 yes serum_aminoacids serum_phospholipids 0.00138 0.222 up up no no no no L-Alanine+blood DHA+blood -0.551879699 0 0 yes serum_aminoacids serum_ARA 0.00138 0.872 up up no no no no L-Alanine+blood DL-methionine sulfoxide+blood 0.577443609 0 0 yes serum_aminoacids serum_aminoacids 0.00138 0.302 up up no no no no L-Alanine+blood ErbB signaling pathway 0 -0.541176471 0 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Estrogen signaling pathway 0 0 -0.488461538 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Faecalibacterium 0 0.573529412 0 yes butyrate-producing serum_aminoacids Genus 0.00138 0.0039 up up no no dn dn L-Alanine+blood Fc gamma R-mediated phagocytosis 0 0 -0.63 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood FoxO signaling pathway 0 0 -0.422307692 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood GCA+blood 0.512781955 0 0 yes yes serum_aminoacids serum_bileacids 0.00138 0.16 up up no no no no L-Alanine+blood GCDCA+blood 0.49924812 0.524509804 0 yes serum_aminoacids serum_bileacids 0.00138 0.31 up up no no no no L-Alanine+blood Glycolysis / Gluconeogenesis 0 0 -0.458461538 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Hepatitis B 0 0 0.403076923 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Insulin resistance 0 0 0.576153846 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Longevity regulating pathway - multiple species 0 0 -0.693846154 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood mRNA surveillance pathway 0 0 0.401538462 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Neuroactive ligand-receptor interaction 0 0 -0.493846154 yes serum_aminoacids kegg 0.00138 NA up up no up up up L-Alanine+blood Neurotrophin signaling pathway 0 0 0.505384615 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Non-small cell lung cancer 0 -0.535294118 0 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Oxytocin signaling pathway 0 0 -0.416923077 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Parabacteroides 0 -0.512254902 0 yes serum_aminoacids Genus 0.00138 4.19E-05 up up no no up up L-Alanine+blood Peroxisome 0 0 -0.506923077 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Pertussis 0 0 -0.42 yes serum_aminoacids kegg 0.00138 NA up up no no no dn L-Alanine+blood Prevotella 0 0 0.437846365 yes acetate-producing serum_aminoacids Genus 0.00138 0.287 up up no no no no L-Alanine+blood Primary immunodeficiency 0 0 -0.487692308 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Prostate cancer 0 0 0.573076923 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Relaxin signaling pathway 0 0 0.451538462 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Renal cell carcinoma 0 -0.594117647 0 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Rheumatoid arthritis 0 0 -0.436153846 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood RIG-I-like receptor signaling pathway 0 0 0.478461538 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Small cell lung cancer 0 0 0.436923077 yes serum_aminoacids kegg 0.00138 NA up up no no no up L-Alanine+blood Sphingolipid signaling pathway 0 -0.561764706 0 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Staphylococcus aureus infection 0 0 -0.416153846 yes serum_aminoacids kegg 0.00138 NA up up no up no no L-Alanine+blood Tight junction 0 0 -0.457692308 yes serum_aminoacids kegg 0.00138 NA up up no no no no L-Alanine+blood Tuberculosis 0 0 -0.480769231 yes serum_aminoacids kegg 0.00138 NA up up no no no dn L-Arginine+blood 12-HEPE+blood 0.534582687 -0.665222712 0 serum_aminoacids serum_ARA 0.316 0.312 no no no no no no L-Arginine+blood 12-ketoDCA+blood 0 0 -0.419130731 serum_aminoacids serum_bileacids 0.316 0.517 no no no no no no L-Arginine+blood 16:0-LPE+blood 0 0 -0.416752137 serum_aminoacids serum_phospholipids 0.316 0.0711 no no no up up no L-Arginine+blood 16:0/14:0-PC+blood 0.521804511 0 0.439316239 serum_aminoacids serum_phospholipids 0.316 0.0206 no no no no up up L-Arginine+blood 16:0/18:0-PS+blood -0.521804511 0 0 serum_aminoacids serum_phospholipids 0.316 0.377 no no no no no no L-Arginine+blood 16:0/18:2-PC+blood 0 0 0.424273504 serum_aminoacids serum_phospholipids 0.316 3.24E-06 no no no no up up L-Arginine+blood 16:0/20:3-PC+blood 0.464661654 0 0 serum_aminoacids serum_phospholipids 0.316 5.43E-06 no no no no up up L-Arginine+blood 16:0/20:4-PC+blood 0 0.536764706 0 serum_aminoacids serum_phospholipids 0.316 0.0262 no no no no up no L-Arginine+blood 16:0/22:6-PC+blood 0 0 0.460512821 serum_aminoacids serum_phospholipids 0.316 4.53E-05 no no no no up up L-Arginine+blood 16:1/16:0-PC+blood 0.454135338 0 0.452307692 serum_aminoacids serum_phospholipids 0.316 0.0215 no no no no up up L-Arginine+blood 18:0/18:0-PE+blood -0.538345865 0 0 serum_aminoacids serum_phospholipids 0.316 0.00896 no no no up up no L-Arginine+blood 18:0/18:1-PE+blood -0.62556391 0 0 serum_aminoacids serum_phospholipids 0.316 0.00716 no no no up up no L-Arginine+blood 18:0/18:2-PC+blood 0 0 0.512478632 serum_aminoacids serum_phospholipids 0.316 1.74E-06 no no no no up up L-Arginine+blood 18:1/16:0-PC+blood 0 0 0.416752137 serum_aminoacids serum_phospholipids 0.316 2.43E-05 no no no no up up L-Arginine+blood 18:1/16:0-PE+blood -0.562406015 0 0 serum_aminoacids serum_phospholipids 0.316 0.000182 no no no up up no L-Arginine+blood 18:1/16:1-PE+blood 0 0 -0.401025641 serum_aminoacids serum_phospholipids 0.316 0.000184 no no no up up no L-Arginine+blood 18:1/18:0-PC+blood 0 0 0.523418803 serum_aminoacids serum_phospholipids 0.316 1.83E-06 no no no no up up L-Arginine+blood 18:1/18:0-PE+blood 0 0 -0.438632479 serum_aminoacids serum_phospholipids 0.316 1.39E-06 no no no up up no L-Arginine+blood 18:1/18:0-PI+blood 0 -0.664215686 0 serum_aminoacids serum_phospholipids 0.316 0.0931 no no no no no up L-Arginine+blood 18:1/18:1-PE+blood -0.517293233 0 -0.465299145 serum_aminoacids serum_phospholipids 0.316 1.03E-05 no no no up up no L-Arginine+blood 18:1/18:2-PE+blood 0 -0.509803922 -0.496068376 serum_aminoacids serum_phospholipids 0.316 0.000293 no no no up up no L-Arginine+blood 18:1/18:2-PG+blood 0 -0.50245098 0 serum_aminoacids serum_phospholipids 0.316 5.58E-07 no no no no up up L-Arginine+blood 18:1/20:3-PC+blood 0.455639098 0 0 serum_aminoacids serum_phospholipids 0.316 0.00872 no no no no up up L-Arginine+blood 18:1/20:4-PE+blood -0.494736842 0 -0.446153846 serum_aminoacids serum_phospholipids 0.316 0.0578 no no no up no no L-Arginine+blood 18:2/16:0-PC+blood 0 0 0.473504274 serum_aminoacids serum_phospholipids 0.316 8.67E-05 no no no no up up L-Arginine+blood 18:3/16:0-PE+blood -0.539849624 0 -0.416752137 serum_aminoacids serum_phospholipids 0.316 0.00149 no no no up up no L-Arginine+blood 18:3n6+blood -0.478195489 0 0 serum_aminoacids serum_fattyacid 0.316 0.0463 no no no up no dn L-Arginine+blood 20:0-LPE+blood 0 -0.526960784 0 serum_aminoacids serum_phospholipids 0.316 0.0615 no no no no no up L-Arginine+blood 20:0/20:4-PE+blood -0.493233083 0 0 serum_aminoacids serum_phospholipids 0.316 0.00128 no no no up up no L-Arginine+blood 20:1-LPE+blood 0 0 0.403760684 serum_aminoacids serum_phospholipids 0.316 0.465 no no no no no no L-Arginine+blood 20:2/18:1-PE+blood -0.517293233 0 -0.40991453 serum_aminoacids serum_phospholipids 0.316 0.00208 no no no up up no L-Arginine+blood 20:3/16:0-PC+blood 0 0.490196078 0.432478632 serum_aminoacids serum_phospholipids 0.316 0.00405 no no no no up up L-Arginine+blood 20:4/16:0-PE+blood 0 0 -0.427008547 serum_aminoacids serum_phospholipids 0.316 0.00529 no no no no up up L-Arginine+blood 20:4/18:0-PE+blood -0.488721805 0 0 serum_aminoacids serum_phospholipids 0.316 0.000755 no no no up up no L-Arginine+blood 24:1+blood 0.563909774 0 0.488547009 serum_aminoacids serum_fattyacid 0.316 0.00582 no no no no dn dn L-Arginine+blood AA+blood 0 0.544117647 0 serum_aminoacids serum_ARA 0.316 0.212 no no no no no no L-Arginine+blood Alistipes 0 0 -0.45592035 serum_aminoacids Genus 0.316 0.0114 no no no no up no L-Arginine+blood Apelin signaling pathway 0 0 0.424615385 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Axon guidance 0 -0.555882353 0 serum_aminoacids kegg 0.316 NA no no no no up up L-Arginine+blood B cell receptor signaling pathway 0.473684211 0 0 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Betaine+blood 0 0 0.422905983 serum_aminoacids serum_choline 0.316 0.857 no no no no no no L-Arginine+blood Chemical carcinogenesis - receptor activation 0 -0.523529412 0 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Choline+blood 0.631578947 0 0 serum_aminoacids serum_choline 0.316 0.0395 no no no no up no L-Arginine+blood Coronavirus disease - COVID-19 0 0 0.506923077 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Creatinine+blood 0.687218045 0 0 serum_aminoacids serum_choline 0.316 0.437 no no no no no no L-Arginine+blood Cysteine+blood 0.455639098 0 0 yes serum_aminoacids serum_aminoacids 0.316 1.81E-07 no no no dn up up L-Arginine+blood Cystine+blood 0.44962406 0 0 yes serum_aminoacids serum_aminoacids 0.316 0.00028 no no no up up no L-Arginine+blood d18:0-16:0-SM+blood -0.553383459 0 0 serum_aminoacids serum_phospholipids 0.316 0.202 no no no no no no L-Arginine+blood d18:0-24:1-SM+blood -0.45112782 0 0 serum_aminoacids serum_phospholipids 0.316 0.0609 no no no no dn dn L-Arginine+blood d18:1-14:1-SM+blood 0 0 -0.403760684 serum_aminoacids serum_phospholipids 0.316 0.0952 no no no no dn no L-Arginine+blood d18:1-16:0-SM+blood -0.527819549 0 0 serum_aminoacids serum_phospholipids 0.316 0.14 no no no no no no L-Arginine+blood d18:1-20:0-SM+blood -0.445112782 0 0 serum_aminoacids serum_phospholipids 0.316 0.933 no no no no no no L-Arginine+blood DHA+blood 0 0.598039216 0 serum_aminoacids serum_ARA 0.316 0.872 no no no no no no L-Arginine+blood Dilated cardiomyopathy 0 0 -0.422307692 serum_aminoacids kegg 0.316 NA no no no no up up L-Arginine+blood DMG+blood 0.448120301 0.549019608 0 serum_aminoacids serum_choline 0.316 0.909 no no no no no no L-Arginine+blood EGFR tyrosine kinase inhibitor resistance 0 0 0.423846154 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Estrogen signaling pathway -0.524561404 0 0 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Glycine+blood 0 0 0.442051282 serum_aminoacids serum_aminoacids 0.316 0.00408 no no no dn no up L-Arginine+blood Glycolysis / Gluconeogenesis -0.564912281 0 0 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood GPC+blood 0 0.534313725 0 serum_aminoacids serum_choline 0.316 0.00427 no no no no up up L-Arginine+blood HIF-1 signaling pathway 0 0 0.5 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Inflammatory bowel disease 0.575438596 0 -0.434615385 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Insulin signaling pathway 0 0 0.423846154 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Intestinal immune network for IgA production 0 0 -0.563076923 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Kaposi sarcoma-associated herpesvirus infection 0.464912281 0 0 serum_aminoacids kegg 0.316 NA no no no no no dn L-Arginine+blood L-2-Aminobutyric acid+blood 0.553383459 0.602941176 0.407179487 yes serum_aminoacids serum_aminoacids 0.316 0.000328 no no no up up no L-Arginine+blood Legionellosis -0.468421053 0 0 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood mTOR signaling pathway 0 0 0.404615385 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Primary immunodeficiency -0.636842105 0 0 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Ribosome 0 0 0.506923077 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Signaling pathways regulating pluripotency of stem cells 0 -0.564705882 0 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Th1 and Th2 cell differentiation 0.538596491 0 0 serum_aminoacids kegg 0.316 NA no no no no no no L-Arginine+blood Th17 cell differentiation 0.510526316 0 0 serum_aminoacids kegg 0.316 NA no no no no no no L-Asparagine+blood 14:0-LPC+blood 0 0 -0.426324786 serum_aminoacids serum_phospholipids 0.784 0.00689 no no no up up no L-Asparagine+blood 14:0/16:0-PC+blood -0.52481203 -0.644607843 0 serum_aminoacids serum_phospholipids 0.784 0.0358 no no no no up no L-Asparagine+blood 14:0/18:2-PC+blood -0.628571429 0 -0.405811966 serum_aminoacids serum_phospholipids 0.784 0.102 no no no no up no L-Asparagine+blood 14:0/20:4-PC+blood -0.631578947 0 0 serum_aminoacids serum_phospholipids 0.784 0.486 no no no no no no L-Asparagine+blood 14:1/18:2-PG+blood 0 0 -0.534358974 serum_aminoacids serum_phospholipids 0.784 0.00259 no no no no up up L-Asparagine+blood 16:0/16:0-PI+blood 0 0 -0.543931624 serum_aminoacids serum_phospholipids 0.784 0.358 no no no no no no L-Asparagine+blood 16:0/16:1-PI+blood 0 0 -0.645811966 serum_aminoacids serum_phospholipids 0.784 0.262 no no no no no no L-Asparagine+blood 16:0/18:0-PS+blood 0 -0.698529412 0 serum_aminoacids serum_phospholipids 0.784 0.377 no no no no no no L-Asparagine+blood 16:0/18:2-PI+blood 0 0 -0.612991453 serum_aminoacids serum_phospholipids 0.784 0.269 no no no no no no L-Asparagine+blood 16:0/20:4-PI+blood 0 0 -0.667692308 serum_aminoacids serum_phospholipids 0.784 0.558 no no no no no no L-Asparagine+blood 16:0/20:5-PC+blood 0 -0.659313725 0 serum_aminoacids serum_phospholipids 0.784 0.628 no no no no no no L-Asparagine+blood 16:0/22:0-PE+blood 0 0 0.549401709 serum_aminoacids serum_phospholipids 0.784 0.00839 no no no dn no up L-Asparagine+blood 16:0/22:6-PC+blood 0 0 0.441367521 serum_aminoacids serum_phospholipids 0.784 4.53E-05 no no no no up up L-Asparagine+blood 16:0/22:6-PE+blood 0 -0.504901961 0 serum_aminoacids serum_phospholipids 0.784 0.000934 no no no up up no L-Asparagine+blood 16:1-LPC+blood 0 0 -0.455042735 serum_aminoacids serum_phospholipids 0.784 0.0241 no no no no up no L-Asparagine+blood 16:1+blood 0 0 -0.402393162 yes serum_aminoacids serum_fattyacid 0.784 0.0186 no no no no no dn L-Asparagine+blood 18:0/18:0-PS+blood 0 -0.791666667 0 serum_aminoacids serum_phospholipids 0.784 0.00617 no no no no up no L-Asparagine+blood 18:0/18:1-PG+blood 0 0 -0.543931624 serum_aminoacids serum_phospholipids 0.784 0.000842 no no no no up no L-Asparagine+blood 18:0/18:2-PC+blood 0 0 0.438632479 serum_aminoacids serum_phospholipids 0.784 1.74E-06 no no no no up up L-Asparagine+blood 18:0/20:3-PC+blood -0.445112782 0 0 serum_aminoacids serum_phospholipids 0.784 0.0682 no no no no up no L-Asparagine+blood 18:0/20:5-PC+blood 0 0 0.410598291 serum_aminoacids serum_phospholipids 0.784 0.17 no no no no no no L-Asparagine+blood 18:0/22:6-PA+blood 0 -0.517156863 0 serum_aminoacids serum_phospholipids 0.784 0.22 no no no no no no L-Asparagine+blood 18:0/22:6-PE+blood 0 -0.534313725 0 serum_aminoacids serum_phospholipids 0.784 0.00022 no no no up up no L-Asparagine+blood 18:1/16:0-PC+blood 0 0 0.40991453 serum_aminoacids serum_phospholipids 0.784 2.43E-05 no no no no up up L-Asparagine+blood 18:1/16:0-PE+blood 0 0 -0.50017094 serum_aminoacids serum_phospholipids 0.784 0.000182 no no no up up no L-Asparagine+blood 18:1/18:0-PC+blood 0 0 0.419487179 serum_aminoacids serum_phospholipids 0.784 1.83E-06 no no no no up up L-Asparagine+blood 18:1/18:0-PE+blood 0 0 -0.442735043 serum_aminoacids serum_phospholipids 0.784 1.39E-06 no no no up up no L-Asparagine+blood 18:1/18:0-PS+blood 0 -0.632352941 0 serum_aminoacids serum_phospholipids 0.784 0.193 no no no no no no L-Asparagine+blood 18:1/18:1-PE+blood 0 0 -0.433846154 serum_aminoacids serum_phospholipids 0.784 1.03E-05 no no no up up no L-Asparagine+blood 18:2-LPA+blood 0 0.632352941 0 serum_aminoacids serum_phospholipids 0.784 0.00684 no no no dn no up L-Asparagine+blood 18:3/16:0-PE+blood 0 0 -0.481709402 serum_aminoacids serum_phospholipids 0.784 0.00149 no no no up up no L-Asparagine+blood 18:3n6+blood 0 0 -0.491965812 serum_aminoacids serum_fattyacid 0.784 0.0463 no no no up no dn L-Asparagine+blood 20:0/20:4-PE+blood 0 0 -0.431111111 serum_aminoacids serum_phospholipids 0.784 0.00128 no no no up up no L-Asparagine+blood 20:1-LPC+blood 0 0 0.453675214 serum_aminoacids serum_phospholipids 0.784 0.217 no no no no no no L-Asparagine+blood 20:2-LPE+blood -0.532330827 0 0 serum_aminoacids serum_phospholipids 0.784 0.177 no no no no no no L-Asparagine+blood 20:2/18:0-PC+blood -0.466165414 0 0 serum_aminoacids serum_phospholipids 0.784 0.0427 no no no no up no L-Asparagine+blood 20:2/18:1-PE+blood 0 0 -0.42974359 serum_aminoacids serum_phospholipids 0.784 0.00208 no no no up up no L-Asparagine+blood 20:4-LPA+blood 0 0.593137255 0 serum_aminoacids serum_phospholipids 0.784 0.398 no no no no no no L-Asparagine+blood 20:4/16:0-PE+blood 0 0 -0.474188034 serum_aminoacids serum_phospholipids 0.784 0.00529 no no no no up up L-Asparagine+blood 20:5n3+blood 0 -0.651960784 0 serum_aminoacids serum_fattyacid 0.784 0.988 no no no no no no L-Asparagine+blood 4-hydroxybenzoic acid+stool 0 0 0.47518797 serum_aminoacids stool_cometabolism 0.784 0.0536 no no no no dn no L-Asparagine+blood 8-HETE+blood 0 0.612745098 0 serum_aminoacids serum_ARA 0.784 0.741 no no no no no no L-Asparagine+blood 9-HODE+blood -0.446616541 0 0 serum_aminoacids serum_ARA 0.784 0.297 no no no no no no L-Asparagine+blood Adipocytokine signaling pathway 0 0.541176471 0 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Alcoholism 0 0 -0.412307692 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Apoptosis 0.461403509 0 0 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Betaine+blood 0 0.529411765 0.437264957 serum_aminoacids serum_choline 0.784 0.857 no no no no no no L-Asparagine+blood Butyricimonas 0 -0.538411071 0 butyrate-producing serum_aminoacids Genus 0.784 0.17 no no no no no no L-Asparagine+blood cAMP signaling pathway 0 0.538235294 -0.401538462 yes serum_aminoacids kegg 0.784 NA no no no no up up L-Asparagine+blood capric acid C6+blood 0 0 0.445470085 serum_aminoacids serum_scfa 0.784 0.433 no no no no no no L-Asparagine+blood Cell cycle -0.489473684 -0.502941176 0 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Choline+blood 0 0.68627451 0 serum_aminoacids serum_choline 0.784 0.0395 no no no no up no L-Asparagine+blood Cocaine addiction 0 0 -0.498461538 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Colorectal cancer 0 -0.558823529 0 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Cortisol synthesis and secretion 0 0 -0.493846154 serum_aminoacids kegg 0.784 NA no no no no no up L-Asparagine+blood Creatinine+blood 0.559398496 0.571078431 0.468717949 serum_aminoacids serum_choline 0.784 0.437 no no no no no no L-Asparagine+blood Cysteine+blood 0 0 0.408547009 yes serum_aminoacids serum_aminoacids 0.784 1.81E-07 no no no dn up up L-Asparagine+blood Cystine+blood 0.687218045 0.49754902 0 yes serum_aminoacids serum_aminoacids 0.784 0.00028 no no no up up no L-Asparagine+blood d18:1-14:0-SM+blood 0 -0.632352941 0 serum_aminoacids serum_phospholipids 0.784 0.94 no no no no no no L-Asparagine+blood d18:1-14:1-SM+blood -0.598496241 -0.526960784 -0.470769231 serum_aminoacids serum_phospholipids 0.784 0.0952 no no no no dn no L-Asparagine+blood d18:1-16:1-SM+blood 0 0 -0.488547009 serum_aminoacids serum_phospholipids 0.784 0.2 no no no no no no L-Asparagine+blood DL-methionine sulfoxide+blood 0 0.541666667 0 serum_aminoacids serum_aminoacids 0.784 0.302 no no no no no no L-Asparagine+blood Endocrine and other factor-regulated calcium reabsorption 0 0 -0.453846154 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Epithelial cell signaling in Helicobacter pylori infection 0 0.547058824 0 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Estrogen signaling pathway -0.510526316 0 0 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Ethanolamine+blood 0.523308271 0.605392157 0 serum_aminoacids serum_aminoacids 0.784 0.122 no no no up no no L-Asparagine+blood Ferroptosis 0.538596491 0 0 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Gap junction 0 0 -0.416153846 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Glycine+blood 0 0.723039216 0.483760684 serum_aminoacids serum_aminoacids 0.784 0.00408 no no no dn no up L-Asparagine+blood GPC+blood 0 0.75245098 0 serum_aminoacids serum_choline 0.784 0.00427 no no no no up up L-Asparagine+blood HDCA+blood 0.457488141 0 0 serum_aminoacids serum_bileacids 0.784 0.483 no no no no no no L-Asparagine+blood heptanoic acid C7+blood 0.532330827 0 0 serum_aminoacids serum_mcfa 0.784 8.27E-11 no no no dn dn no L-Asparagine+blood Hypotaurine+blood 0 0.708333333 0 serum_aminoacids serum_aminoacids 0.784 0.933 no no no no no no L-Asparagine+blood Influenza A 0.501754386 0 0 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Insulin secretion 0 0 -0.434615385 yes serum_aminoacids kegg 0.784 NA no no no no up up L-Asparagine+blood iso-DCA+blood 0 0.49754902 0 serum_aminoacids serum_bileacids 0.784 0.38 no no no no no no L-Asparagine+blood L-Alanine+blood 0.664661654 0 0 yes serum_aminoacids serum_aminoacids 0.784 0.00138 no no no up up no L-Asparagine+blood L-Arginine+blood 0 0 0.485128205 serum_aminoacids serum_aminoacids 0.784 0.316 no no no no no no L-Asparagine+blood L-Phenylalanine+stool 0 0 0.551879699 serum_aminoacids stool_cometabolism 0.784 0.398 no no no no no no L-Asparagine+blood L-Tyrosine+stool 0 0 0.616541353 serum_aminoacids stool_cometabolism 0.784 0.44 no no no no no no L-Asparagine+blood Long-term depression 0 0 -0.569230769 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Longevity regulating pathway - multiple species -0.512280702 0 0 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Morphine addiction 0 0 -0.405384615 serum_aminoacids kegg 0.784 NA no no no no up up L-Asparagine+blood Oocyte meiosis 0 -0.5 0 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Pancreatic secretion 0 0 -0.402307692 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Primary immunodeficiency -0.466666667 0 0 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Progesterone-mediated oocyte maturation -0.470175439 0 0 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Ras signaling pathway 0 -0.547058824 0 yes serum_aminoacids kegg 0.784 NA no no no no up up L-Asparagine+blood Regulation of lipolysis in adipocytes 0 0 -0.477692308 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Relaxin signaling pathway 0 0 -0.425384615 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Renin secretion 0 0 -0.401538462 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood RIG-I-like receptor signaling pathway 0 0 -0.413076923 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Small cell lung cancer 0 0 -0.424615385 serum_aminoacids kegg 0.784 NA no no no no no up L-Asparagine+blood Spinocerebellar ataxia 0 -0.585294118 0 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Transcriptional misregulation in cancer 0 0 -0.447692308 serum_aminoacids kegg 0.784 NA no no no no no no L-Asparagine+blood Vasopressin-regulated water reabsorption 0 0 -0.403076923 serum_aminoacids kegg 0.784 NA no no no no no no L-Aspartic acid+blood 13-HODE+blood 0 0.580882353 0 yes serum_aminoacids serum_ARA 0.0226 0.32 up up no no no no L-Aspartic acid+blood 14:0/18:2-PC+blood -0.460150376 0 0 yes serum_aminoacids serum_phospholipids 0.0226 0.102 up up no no up no L-Aspartic acid+blood 16:0/14:0-PC+blood 0 0.659313725 0.431794872 yes serum_aminoacids serum_phospholipids 0.0226 0.0206 up up no no up up L-Aspartic acid+blood 16:0/16:0-PC+blood 0 0.517156863 0 yes serum_aminoacids serum_phospholipids 0.0226 0.00079 up up no no up up L-Aspartic acid+blood 16:0/18:2-PC+blood 0 0.575980392 0 yes serum_aminoacids serum_phospholipids 0.0226 3.24E-06 up up no no up up L-Aspartic acid+blood 16:0/20:4-PC+blood 0.50075188 0.590686275 0 yes serum_aminoacids serum_phospholipids 0.0226 0.0262 up up no no up no L-Aspartic acid+blood 16:0/20:4-PI+blood 0 -0.585784314 0 yes serum_aminoacids serum_phospholipids 0.0226 0.558 up up no no no no L-Aspartic acid+blood 16:0/22:6-PE+blood 0 0 -0.414017094 yes serum_aminoacids serum_phospholipids 0.0226 0.000934 up up no up up no L-Aspartic acid+blood 18:0-LPC+blood -0.505263158 0 0 yes serum_aminoacids serum_phospholipids 0.0226 0.554 up up no no no no L-Aspartic acid+blood 18:0/16:0-PC+blood 0 0.482843137 0 yes serum_aminoacids serum_phospholipids 0.0226 9.64E-07 up up no up up up L-Aspartic acid+blood 18:0/18:0-PE+blood 0 -0.492647059 -0.541880342 yes serum_aminoacids serum_phospholipids 0.0226 0.00896 up up no up up no L-Aspartic acid+blood 18:0/18:1-PE+blood 0 0 -0.519316239 yes serum_aminoacids serum_phospholipids 0.0226 0.00716 up up no up up no L-Aspartic acid+blood 18:0/18:1-PG+blood 0 -0.585784314 0 yes serum_aminoacids serum_phospholipids 0.0226 0.000842 up up no no up no L-Aspartic acid+blood 18:0/20:3-PC+blood -0.52481203 0 0 yes serum_aminoacids serum_phospholipids 0.0226 0.0682 up up no no up no L-Aspartic acid+blood 18:0/22:6-PC+blood 0 0 0.55965812 yes serum_aminoacids serum_phospholipids 0.0226 0.0775 up up no no no up L-Aspartic acid+blood 18:0+blood 0 0 0.414700855 yes serum_aminoacids serum_fattyacid 0.0226 0.344 up up no no no no L-Aspartic acid+blood 18:1/16:0-PC+blood 0 0.615196078 0 yes serum_aminoacids serum_phospholipids 0.0226 2.43E-05 up up no no up up L-Aspartic acid+blood 18:1/16:0-PE+blood 0 0 -0.491282051 yes serum_aminoacids serum_phospholipids 0.0226 0.000182 up up no up up no L-Aspartic acid+blood 18:1/18:0-PE+blood 0 0 -0.565128205 yes serum_aminoacids serum_phospholipids 0.0226 1.39E-06 up up no up up no L-Aspartic acid+blood 18:1/18:1-PE+blood 0 0 -0.605470085 yes serum_aminoacids serum_phospholipids 0.0226 1.03E-05 up up no up up no L-Aspartic acid+blood 18:1/18:1-PG+blood 0 -0.495098039 0 yes serum_aminoacids serum_phospholipids 0.0226 0.00352 up up no no up up L-Aspartic acid+blood 18:1/18:2-PE+blood 0 0 -0.759316239 yes serum_aminoacids serum_phospholipids 0.0226 0.000293 up up no up up no L-Aspartic acid+blood 18:1/18:2-PG+blood 0 -0.495098039 0 yes serum_aminoacids serum_phospholipids 0.0226 5.58E-07 up up no no up up L-Aspartic acid+blood 18:1/20:4-PE+blood 0 0 -0.524102564 yes serum_aminoacids serum_phospholipids 0.0226 0.0578 up up no up no no L-Aspartic acid+blood 18:1/20:4-PI+blood 0 -0.492647059 0 yes serum_aminoacids serum_phospholipids 0.0226 0.192 up up no no no no L-Aspartic acid+blood 18:2/16:0-PC+blood 0 0.504901961 0 yes serum_aminoacids serum_phospholipids 0.0226 8.67E-05 up up no no up up L-Aspartic acid+blood 18:3/18:2-PC+blood -0.54887218 0 0 yes serum_aminoacids serum_phospholipids 0.0226 0.0394 up up no no no up L-Aspartic acid+blood 18:3n6+blood 0 -0.639705882 0 yes serum_aminoacids serum_fattyacid 0.0226 0.0463 up up no up no dn L-Aspartic acid+blood 20:0/20:4-PE+blood 0 0 -0.542564103 yes serum_aminoacids serum_phospholipids 0.0226 0.00128 up up no up up no L-Aspartic acid+blood 20:1/20:4-PC+blood 0 0 0.531623932 yes serum_aminoacids serum_phospholipids 0.0226 0.0419 up up no no no up L-Aspartic acid+blood 20:1/20:4-PE+blood 0 0 -0.40991453 yes serum_aminoacids serum_phospholipids 0.0226 0.0042 up up no up up no L-Aspartic acid+blood 20:2-LPC+blood 0 0.56372549 0 yes serum_aminoacids serum_phospholipids 0.0226 0.119 up up no no no up L-Aspartic acid+blood 20:2/18:0-PC+blood -0.511278195 0 0 yes serum_aminoacids serum_phospholipids 0.0226 0.0427 up up no no up no L-Aspartic acid+blood 20:2/18:1-PE+blood -0.448120301 0 -0.544615385 yes serum_aminoacids serum_phospholipids 0.0226 0.00208 up up no up up no L-Aspartic acid+blood 20:2/18:3-PE+blood 0 0 -0.504273504 yes serum_aminoacids serum_phospholipids 0.0226 0.0391 up up no up up no L-Aspartic acid+blood 20:3/16:0-PC+blood 0.503759398 0.612745098 0 yes serum_aminoacids serum_phospholipids 0.0226 0.00405 up up no no up up L-Aspartic acid+blood 20:3/18:0-PC+blood 0 0.615196078 0.416752137 yes serum_aminoacids serum_phospholipids 0.0226 0.296 up up no no no no L-Aspartic acid+blood 20:4/16:0-PE+blood -0.565413534 0 -0.418119658 yes serum_aminoacids serum_phospholipids 0.0226 0.00529 up up no no up up L-Aspartic acid+blood 20:4/18:0-PE+blood 0 0 -0.401025641 yes serum_aminoacids serum_phospholipids 0.0226 0.000755 up up no up up no L-Aspartic acid+blood 20:5/18:0-PC+blood 0 0.50245098 0 yes serum_aminoacids serum_phospholipids 0.0226 3.97E-06 up up no no up up L-Aspartic acid+blood 22:6-LPC+blood 0 0 0.512478632 yes serum_aminoacids serum_phospholipids 0.0226 0.127 up up no no no up L-Aspartic acid+blood 22:6n3+blood 0 0 0.483076923 yes serum_aminoacids serum_fattyacid 0.0226 0.792 up up no no no no L-Aspartic acid+blood 8-HETE+blood 0 0.647058824 0 yes serum_aminoacids serum_ARA 0.0226 0.741 up up no no no no L-Aspartic acid+blood Alistipes 0 0 -0.406520402 yes serum_aminoacids Genus 0.0226 0.0114 up up no no up no L-Aspartic acid+blood AMPK signaling pathway 0.473684211 0 0 yes serum_aminoacids kegg 0.0226 NA up up no no no no L-Aspartic acid+blood Axon guidance -0.61754386 0 -0.443846154 yes serum_aminoacids kegg 0.0226 NA up up no no up up L-Aspartic acid+blood Betaine+blood 0 0 0.409230769 yes serum_aminoacids serum_choline 0.0226 0.857 up up no no no no L-Aspartic acid+blood Cardiac muscle contraction -0.456140351 0 0 yes serum_aminoacids kegg 0.0226 NA up up no no no up L-Aspartic acid+blood Cystine+blood 0.47518797 0 0 yes yes serum_aminoacids serum_aminoacids 0.0226 0.00028 up up no up up no L-Aspartic acid+blood Diabetic cardiomyopathy -0.485964912 0 0 yes serum_aminoacids kegg 0.0226 NA up up no no no no L-Aspartic acid+blood DPA+blood 0 0 0.403076923 yes serum_aminoacids serum_ARA 0.0226 0.519 up up no no no no L-Aspartic acid+blood EPA+blood 0 0 0.425641026 yes serum_aminoacids serum_ARA 0.0226 0.212 up up no no no no L-Aspartic acid+blood Estrogen signaling pathway 0 0 -0.546153846 yes serum_aminoacids kegg 0.0226 NA up up no no no no L-Aspartic acid+blood Ethanolamine+blood 0.481203008 0 0 yes serum_aminoacids serum_aminoacids 0.0226 0.122 up up no up no no L-Aspartic acid+blood Ferroptosis 0.466666667 0 0 yes serum_aminoacids kegg 0.0226 NA up up no no no no L-Aspartic acid+blood Glioma -0.524561404 -0.688235294 -0.415384615 yes serum_aminoacids kegg 0.0226 NA up up no no no no L-Aspartic acid+blood Glycine+blood 0.760902256 0 0.43042735 yes serum_aminoacids serum_aminoacids 0.0226 0.00408 up up no dn no up L-Aspartic acid+blood GPC+blood 0 0.644607843 0 yes serum_aminoacids serum_choline 0.0226 0.00427 up up no no up up L-Aspartic acid+blood HDCA+blood 0.487794926 0 0 yes serum_aminoacids serum_bileacids 0.0226 0.483 up up no no no no L-Aspartic acid+blood Hypotaurine+blood 0 0.578431373 0 yes serum_aminoacids serum_aminoacids 0.0226 0.933 up up no no no no L-Aspartic acid+blood Intestinal immune network for IgA production 0 0 -0.445384615 yes serum_aminoacids kegg 0.0226 NA up up no no no no L-Aspartic acid+blood L-Arginine+blood 0 0.534313725 0.473504274 yes serum_aminoacids serum_aminoacids 0.0226 0.316 up up no no no no L-Aspartic acid+blood L-Asparagine+blood 0.452631579 0 0 yes serum_aminoacids serum_aminoacids 0.0226 0.784 up up no no no no L-Aspartic acid+blood Long-term potentiation -0.540350877 0 0 yes serum_aminoacids kegg 0.0226 NA up up no no no up L-Aspartic acid+blood Measles 0 0 0.44 yes serum_aminoacids kegg 0.0226 NA up up no no no no L-Aspartic acid+blood Pancreatic cancer -0.459649123 0 -0.583846154 yes serum_aminoacids kegg 0.0226 NA up up no no no no L-Aspartic acid+blood Phosphatidylinositol signaling system 0 -0.544117647 0 yes serum_aminoacids kegg 0.0226 NA up up no no no no L-Aspartic acid+blood Porphyrin and chlorophyll metabolism 0.459649123 0 0 yes serum_aminoacids kegg 0.0226 NA up up no no no no L-Aspartic acid+blood Purine metabolism 0.510526316 0 0 yes serum_aminoacids kegg 0.0226 NA up up no no no no L-Aspartic acid+blood TGF-beta signaling pathway -0.498245614 0 0 yes serum_aminoacids kegg 0.0226 NA up up no no no no L-Citrulline+blood 11-HETE+blood 0.468449746 0 0 serum_aminoacids serum_ARA 0.534 0.464 no no no no no no L-Citrulline+blood 12-HEPE+blood 0.459595975 -0.517029533 0 serum_aminoacids serum_ARA 0.534 0.312 no no no no no no L-Citrulline+blood 13-HODE+blood 0 0 0.429059829 serum_aminoacids serum_ARA 0.534 0.32 no no no no no no L-Citrulline+blood 14:0+blood -0.52481203 0 0 yes serum_aminoacids serum_fattyacid 0.534 0.00572 no no no up no dn L-Citrulline+blood 16:0-LPE+blood 0 0 -0.483076923 serum_aminoacids serum_phospholipids 0.534 0.0711 no no no up up no L-Citrulline+blood 16:0/16:1-PC+blood 0 0 -0.40991453 serum_aminoacids serum_phospholipids 0.534 0.00283 no no no up up no L-Citrulline+blood 16:0/16:1-PI+blood 0 0 -0.416068376 serum_aminoacids serum_phospholipids 0.534 0.262 no no no no no no L-Citrulline+blood 16:0/18:0-PS+blood -0.49924812 -0.575980392 0 serum_aminoacids serum_phospholipids 0.534 0.377 no no no no no no L-Citrulline+blood 16:0/18:1-PE+blood 0 0 -0.55008547 serum_aminoacids serum_phospholipids 0.534 0.000107 no no no up up no L-Citrulline+blood 16:0/18:2-PI+blood 0 0 -0.432478632 serum_aminoacids serum_phospholipids 0.534 0.269 no no no no no no L-Citrulline+blood 16:0/20:4-PE+blood 0 0 -0.408547009 serum_aminoacids serum_phospholipids 0.534 0.00139 no no no up up no L-Citrulline+blood 16:0/20:4-PI+blood 0 0 -0.565128205 serum_aminoacids serum_phospholipids 0.534 0.558 no no no no no no L-Citrulline+blood 16:0/20:5-PC+blood 0 -0.524509804 0 serum_aminoacids serum_phospholipids 0.534 0.628 no no no no no no L-Citrulline+blood 16:0/22:6-PE+blood 0 0 -0.446153846 serum_aminoacids serum_phospholipids 0.534 0.000934 no no no up up no L-Citrulline+blood 18:0-LPC+blood 0 0 0.461880342 serum_aminoacids serum_phospholipids 0.534 0.554 no no no no no no L-Citrulline+blood 18:0/18:0-PS+blood 0 -0.549019608 0 serum_aminoacids serum_phospholipids 0.534 0.00617 no no no no up no L-Citrulline+blood 18:1/16:1-PE+blood 0 0 -0.541880342 serum_aminoacids serum_phospholipids 0.534 0.000184 no no no up up no L-Citrulline+blood 18:1/18:0-PE+blood 0 0 -0.460512821 serum_aminoacids serum_phospholipids 0.534 1.39E-06 no no no up up no L-Citrulline+blood 18:1/18:1-PE+blood 0 0 -0.42017094 serum_aminoacids serum_phospholipids 0.534 1.03E-05 no no no up up no L-Citrulline+blood 18:3/16:0-PE+blood 0 0 -0.428376068 serum_aminoacids serum_phospholipids 0.534 0.00149 no no no up up no L-Citrulline+blood 20:0-LPC+blood 0 0 0.436581197 serum_aminoacids serum_phospholipids 0.534 0.199 no no no no no no L-Citrulline+blood 20:1+blood 0 0 0.435213675 yes serum_aminoacids serum_fattyacid 0.534 2.56E-05 no no no dn dn dn L-Citrulline+blood 20:2/18:1-PE+blood 0 0 -0.476239316 serum_aminoacids serum_phospholipids 0.534 0.00208 no no no up up no L-Citrulline+blood 20:3n6+blood 0 0 -0.473504274 serum_aminoacids serum_fattyacid 0.534 0.0884 no no no up no no L-Citrulline+blood 24:0+blood -0.50075188 0 0 serum_aminoacids serum_fattyacid 0.534 0.034 no no no dn no up L-Citrulline+blood "9,10-EPOME+blood" 0 0 0.422363627 serum_aminoacids serum_ARA 0.534 0.801 no no no no no no L-Citrulline+blood ACA+stool 0 0 -0.545676063 serum_aminoacids stool_bileacids 0.534 0.417 no no no no no no L-Citrulline+blood Adherens junction 0 -0.5 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Adipocytokine signaling pathway 0.633333333 0.644117647 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Allograft rejection 0 0 -0.474615385 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood AMPK signaling pathway 0 0.511764706 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Arrhythmogenic right ventricular cardiomyopathy -0.524561404 -0.5 0 serum_aminoacids kegg 0.534 NA no no no no up up L-Citrulline+blood Asthma 0 -0.652941176 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Autoimmune thyroid disease 0 0 -0.474615385 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Autophagy - animal 0.605263158 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood B cell receptor signaling pathway 0.550877193 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Bacterial invasion of epithelial cells -0.470175439 -0.558823529 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Betaine+blood 0 0 0.429059829 serum_aminoacids serum_choline 0.534 0.857 no no no no no no L-Citrulline+blood Butyric acid+stool 0 0.609090909 0 yes serum_aminoacids stool_scfa 0.534 0.102 no no no dn no no L-Citrulline+blood C-type lectin receptor signaling pathway 0.621052632 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Carbon metabolism -0.561403509 -0.520588235 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Cell adhesion molecules 0 0 -0.578461538 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Choline+blood 0.473684211 0 0 serum_aminoacids serum_choline 0.534 0.0395 no no no no up no L-Citrulline+blood Chronic myeloid leukemia 0.564912281 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Circadian entrainment -0.545614035 0 0 serum_aminoacids kegg 0.534 NA no no no no up up L-Citrulline+blood Clostridium 0 -0.581585543 0 serum_aminoacids Genus 0.534 0.925 no no no no no no L-Citrulline+blood Creatinine+blood 0.553383459 0 0 serum_aminoacids serum_choline 0.534 0.437 no no no no no no L-Citrulline+blood d18:1-14:1-SM+blood -0.508270677 0 0 serum_aminoacids serum_phospholipids 0.534 0.0952 no no no no dn no L-Citrulline+blood d18:1-20:0-SM+blood -0.55037594 0 0 serum_aminoacids serum_phospholipids 0.534 0.933 no no no no no no L-Citrulline+blood DHA+blood -0.455639098 0 0 serum_aminoacids serum_ARA 0.534 0.872 no no no no no no L-Citrulline+blood Dilated cardiomyopathy -0.592982456 0 0 serum_aminoacids kegg 0.534 NA no no no no up up L-Citrulline+blood DMG+blood 0.494736842 0 0.447521368 serum_aminoacids serum_choline 0.534 0.909 no no no no no no L-Citrulline+blood Estrogen signaling pathway -0.710526316 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Ferroptosis 0 0 -0.433076923 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Fluid shear stress and atherosclerosis 0 -0.529411765 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Focal adhesion -0.664912281 -0.5 0 serum_aminoacids kegg 0.534 NA no no no no up up L-Citrulline+blood Gap junction -0.503508772 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Gastric acid secretion -0.51754386 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Glycine+blood 0 0.62254902 0 serum_aminoacids serum_aminoacids 0.534 0.00408 no no no dn no up L-Citrulline+blood Glycolysis / Gluconeogenesis -0.650877193 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Graft-versus-host disease 0 0 -0.480769231 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood HDCA+stool 0 0.7 0 serum_aminoacids stool_bileacids 0.534 0.176 no no no no no no L-Citrulline+blood Hematopoietic cell lineage 0 -0.535294118 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Hepatitis B 0.515789474 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Hepatocellular carcinoma 0 -0.520588235 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Hippo signaling pathway -0.550877193 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Human papillomavirus infection 0 0 -0.446923077 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Hypertrophic cardiomyopathy -0.533333333 -0.541176471 0 serum_aminoacids kegg 0.534 NA no no no no up up L-Citrulline+blood Hypotaurine+blood 0 0.566176471 0.490598291 serum_aminoacids serum_aminoacids 0.534 0.933 no no no no no no L-Citrulline+blood Inflammatory bowel disease 0.494736842 -0.670588235 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Insulin resistance 0.58245614 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Intestinal immune network for IgA production 0 -0.579411765 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood iso-DCA+blood 0 0.487745098 0 serum_aminoacids serum_bileacids 0.534 0.38 no no no no no no L-Citrulline+blood Kaposi sarcoma-associated herpesvirus infection 0 0 -0.454615385 serum_aminoacids kegg 0.534 NA no no no no no dn L-Citrulline+blood L-2-Aminobutyric acid+blood 0 0 0.485811966 yes serum_aminoacids serum_aminoacids 0.534 0.000328 no no no up up no L-Citrulline+blood L-Arginine+blood 0.727819549 0 0.546666667 serum_aminoacids serum_aminoacids 0.534 0.316 no no no no no no L-Citrulline+blood L-Asparagine+blood 0.446616541 0.578431373 0.491282051 serum_aminoacids serum_aminoacids 0.534 0.784 no no no no no no L-Citrulline+blood Leukocyte transendothelial migration -0.464912281 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Longevity regulating pathway 0 0.758823529 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Longevity regulating pathway - multiple species -0.459649123 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Methanobrevibacter 0 0 0.44849889 serum_aminoacids Genus 0.534 0.629 no no no no no no L-Citrulline+blood mRNA surveillance pathway 0.464912281 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Oxytocin signaling pathway -0.561403509 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood p53 signaling pathway 0.524561404 0.532352941 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Pathways in cancer 0 0.538235294 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood PD-L1 expression and PD-1 checkpoint pathway in cancer 0.585964912 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Phagosome 0 0 -0.435384615 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Phosphatidylinositol signaling system 0 0 0.513846154 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Platelet activation -0.622807018 -0.544117647 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Primary immunodeficiency -0.577192982 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Progesterone-mediated oocyte maturation 0 0 0.523076923 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Prostate cancer 0.515789474 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Purine metabolism 0 0.532352941 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Rap1 signaling pathway -0.512280702 -0.505882353 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Ras signaling pathway 0 0 0.447692308 yes serum_aminoacids kegg 0.534 NA no no no no up up L-Citrulline+blood Regulation of actin cytoskeleton -0.612280702 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Renin secretion -0.552631579 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Ribosome biogenesis in eukaryotes 0 0 0.463076923 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood RIG-I-like receptor signaling pathway 0.568421053 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Small cell lung cancer 0.536842105 0 0 serum_aminoacids kegg 0.534 NA no no no no no up L-Citrulline+blood Spinocerebellar ataxia 0 0 0.461538462 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Th1 and Th2 cell differentiation 0.629824561 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Th17 cell differentiation 0.678947368 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood TNF signaling pathway 0.550877193 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Transcriptional misregulation in cancer 0.492982456 0 0 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Type I diabetes mellitus 0 0 -0.476923077 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Viral carcinogenesis 0 0 -0.432307692 serum_aminoacids kegg 0.534 NA no no no no no no L-Citrulline+blood Viral myocarditis 0 0 -0.513076923 serum_aminoacids kegg 0.534 NA no no no no no no L-Glutamic acid+blood 13-HODE+blood 0 0.49754902 0 yes serum_aminoacids serum_ARA 6.20E-05 0.32 up up no no no no L-Glutamic acid+blood 16:0/14:0-PC+blood 0 0.514705882 0 yes serum_aminoacids serum_phospholipids 6.20E-05 0.0206 up up no no up up L-Glutamic acid+blood 16:0/18:2-PC+blood 0 0.580882353 0 yes serum_aminoacids serum_phospholipids 6.20E-05 3.24E-06 up up no no up up L-Glutamic acid+blood 16:0/22:6-PE+blood 0 0 -0.434529915 yes serum_aminoacids serum_phospholipids 6.20E-05 0.000934 up up no up up no L-Glutamic acid+blood 18:0+blood 0 0 0.426324786 yes serum_aminoacids serum_fattyacid 6.20E-05 0.344 up up no no no no L-Glutamic acid+blood 18:1/16:0-PC+blood 0 0.578431373 0 yes serum_aminoacids serum_phospholipids 6.20E-05 2.43E-05 up up no no up up L-Glutamic acid+blood 18:1/18:0-PE+blood 0 0 -0.418803419 yes serum_aminoacids serum_phospholipids 6.20E-05 1.39E-06 up up no up up no L-Glutamic acid+blood 18:1/18:1-PE+blood 0 0 -0.43042735 yes serum_aminoacids serum_phospholipids 6.20E-05 1.03E-05 up up no up up no L-Glutamic acid+blood 18:1/18:2-PE+blood 0 0 -0.535042735 yes serum_aminoacids serum_phospholipids 6.20E-05 0.000293 up up no up up no L-Glutamic acid+blood 18:1/20:4-PE+blood 0 -0.487745098 0 yes serum_aminoacids serum_phospholipids 6.20E-05 0.0578 up up no up no no L-Glutamic acid+blood 18:2/16:0-PC+blood 0 0.573529412 0 yes serum_aminoacids serum_phospholipids 6.20E-05 8.67E-05 up up no no up up L-Glutamic acid+blood 18:3/18:2-PC+blood -0.563909774 0 0 yes serum_aminoacids serum_phospholipids 6.20E-05 0.0394 up up no no no up L-Glutamic acid+blood 20:0-LPC+blood 0 -0.514705882 0 yes serum_aminoacids serum_phospholipids 6.20E-05 0.199 up up no no no no L-Glutamic acid+blood 20:0+blood 0 -0.514705882 0 yes yes serum_aminoacids serum_fattyacid 6.20E-05 0.000278 up up no dn no up L-Glutamic acid+blood 20:2/18:1-PE+blood 0 0 -0.415384615 yes serum_aminoacids serum_phospholipids 6.20E-05 0.00208 up up no up up no L-Glutamic acid+blood 20:2/18:3-PE+blood 0 0 -0.44 yes serum_aminoacids serum_phospholipids 6.20E-05 0.0391 up up no up up no L-Glutamic acid+blood 20:4-LPC+blood 0.6 0 0 yes serum_aminoacids serum_phospholipids 6.20E-05 0.949 up up no no no no L-Glutamic acid+blood 5-HETE+blood 0 0.482269873 0 yes serum_aminoacids serum_ARA 6.20E-05 0.697 up up no no no no L-Glutamic acid+blood Adherens junction 0 0 -0.401538462 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Alistipes 0 -0.683016683 0 yes serum_aminoacids Genus 6.20E-05 0.0114 up up no no up no L-Glutamic acid+blood Amoebiasis 0 0 -0.460769231 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood AMPK signaling pathway 0 -0.505882353 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Antigen processing and presentation 0 0 -0.485384615 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Axon guidance -0.457894737 0 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no up up L-Glutamic acid+blood Bacterial invasion of epithelial cells 0 0 -0.43 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Betaine+blood 0 0.634803922 0 yes serum_aminoacids serum_choline 6.20E-05 0.857 up up no no no no L-Glutamic acid+blood Blautia 0 0.571078431 0 yes acetate-producing serum_aminoacids Genus 6.20E-05 1.36E-05 up up no up dn dn L-Glutamic acid+blood Cell adhesion molecules 0 0 -0.444615385 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Cell cycle -0.561403509 0 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Chemical carcinogenesis - receptor activation 0 -0.558823529 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Choline+blood 0 0.696078431 0 yes serum_aminoacids serum_choline 6.20E-05 0.0395 up up no no up no L-Glutamic acid+blood Cholinergic synapse 0 -0.564705882 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Circadian entrainment 0 0 -0.412307692 yes serum_aminoacids kegg 6.20E-05 NA up up no no up up L-Glutamic acid+blood Colorectal cancer 0 -0.629411765 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Creatinine+blood 0.520300752 0.620098039 0 yes serum_aminoacids serum_choline 6.20E-05 0.437 up up no no no no L-Glutamic acid+blood Cystine+blood 0.520300752 0.590686275 0 yes yes serum_aminoacids serum_aminoacids 6.20E-05 0.00028 up up no up up no L-Glutamic acid+blood d18:1-14:0-SM+blood 0 -0.485294118 0 yes serum_aminoacids serum_phospholipids 6.20E-05 0.94 up up no no no no L-Glutamic acid+blood d18:1-14:1-SM+blood -0.526315789 -0.669117647 0 yes serum_aminoacids serum_phospholipids 6.20E-05 0.0952 up up no no dn no L-Glutamic acid+blood d18:1-16:1-SM+blood 0 -0.514705882 0 yes serum_aminoacids serum_phospholipids 6.20E-05 0.2 up up no no no no L-Glutamic acid+blood d18:1-22:1-SM+blood 0 -0.509803922 0 yes serum_aminoacids serum_phospholipids 6.20E-05 0.222 up up no no no no L-Glutamic acid+blood DHA+blood 0 0.509803922 0 yes serum_aminoacids serum_ARA 6.20E-05 0.872 up up no no no no L-Glutamic acid+blood Dilated cardiomyopathy 0 0 -0.564615385 yes serum_aminoacids kegg 6.20E-05 NA up up no no up up L-Glutamic acid+blood DL-methionine sulfoxide+blood 0 0.534313725 0 yes serum_aminoacids serum_aminoacids 6.20E-05 0.302 up up no no no no L-Glutamic acid+blood DMG+blood 0 0.544117647 0 yes serum_aminoacids serum_choline 6.20E-05 0.909 up up no no no no L-Glutamic acid+blood Dorea 0 0.49754902 0 yes serum_aminoacids Genus 6.20E-05 0.00362 up up no up no dn L-Glutamic acid+blood Estrogen signaling pathway 0 0 -0.577692308 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Ethanolamine+blood 0.568421053 0 0 yes serum_aminoacids serum_aminoacids 6.20E-05 0.122 up up no up no no L-Glutamic acid+blood Focal adhesion 0 0 -0.468461538 yes serum_aminoacids kegg 6.20E-05 NA up up no no up up L-Glutamic acid+blood Gap junction 0 0 -0.443076923 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Gastric acid secretion 0 0 -0.487692308 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Gastric cancer 0 -0.611764706 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood GPC+blood 0 0.634803922 0 yes serum_aminoacids serum_choline 6.20E-05 0.00427 up up no no up up L-Glutamic acid+blood Human T-cell leukemia virus 1 infection 0 0 -0.429230769 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Influenza A 0.521052632 0.576470588 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Insulin resistance 0 0 0.544615385 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood L-2-Aminobutyric acid+blood 0 0 0.474188034 yes yes serum_aminoacids serum_aminoacids 6.20E-05 0.000328 up up no up up no L-Glutamic acid+blood L-Alanine+blood 0.581954887 0 0.50974359 yes yes serum_aminoacids serum_aminoacids 6.20E-05 0.00138 up up no up up no L-Glutamic acid+blood L-Arginine+blood 0 0.566176471 0 yes serum_aminoacids serum_aminoacids 6.20E-05 0.316 up up no no no no L-Glutamic acid+blood L-Asparagine+blood 0.472180451 0.539215686 0 yes serum_aminoacids serum_aminoacids 6.20E-05 0.784 up up no no no no L-Glutamic acid+blood L-Aspartic acid+blood 0 0.600490196 0.647179487 yes yes serum_aminoacids serum_aminoacids 6.20E-05 0.0226 up up no up up no L-Glutamic acid+blood L-Citrulline+blood 0 0 0.416752137 yes serum_aminoacids serum_aminoacids 6.20E-05 0.534 up up no no no no L-Glutamic acid+blood Leukocyte transendothelial migration 0 0 -0.424615385 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Oocyte meiosis -0.456140351 0 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Oxytocin signaling pathway 0 0 -0.533846154 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Phosphatidylinositol signaling system 0 -0.502941176 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Phospholipase D signaling pathway 0.49122807 0 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no up up L-Glutamic acid+blood Platelet activation 0 0 -0.467692308 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Platinum drug resistance 0 -0.547058824 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Prion disease 0 0 -0.42 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Regulation of actin cytoskeleton 0 0 -0.467692308 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Renin secretion 0 0 -0.401538462 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Rheumatoid arthritis 0 0 -0.426153846 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Salivary secretion 0 0 -0.42 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Salmonella infection 0 0.564705882 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Serotonergic synapse 0 0 -0.503846154 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Signaling pathways regulating pluripotency of stem cells 0 -0.620588235 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Systemic lupus erythematosus 0 0 -0.410769231 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood TGF-beta signaling pathway -0.473684211 0 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Tight junction 0 0 -0.447692308 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamic acid+blood Yersinia infection 0 0.605882353 0 yes serum_aminoacids kegg 6.20E-05 NA up up no no no no L-Glutamine+blood 14:0-LPC+blood 0 0 -0.608888889 serum_aminoacids serum_phospholipids 0.639 0.00689 no no no up up no L-Glutamine+blood 14:0/16:0-PC+blood 0 0 -0.431794872 serum_aminoacids serum_phospholipids 0.639 0.0358 no no no no up no L-Glutamine+blood 14:0/18:0-PC+blood 0 0 -0.461196581 serum_aminoacids serum_phospholipids 0.639 0.00289 no no no up up no L-Glutamine+blood 14:0/18:2-PC+blood -0.481203008 0 -0.634871795 serum_aminoacids serum_phospholipids 0.639 0.102 no no no no up no L-Glutamine+blood 14:0/20:4-PC+blood 0 0 -0.541880342 serum_aminoacids serum_phospholipids 0.639 0.486 no no no no no no L-Glutamine+blood 14:0+blood -0.488721805 0 -0.486495726 yes serum_aminoacids serum_fattyacid 0.639 0.00572 no no no up no dn L-Glutamine+blood 14:1/18:2-PG+blood 0 0 -0.648547009 serum_aminoacids serum_phospholipids 0.639 0.00259 no no no no up up L-Glutamine+blood 16:0/14:0-PC+blood 0 0 0.483760684 serum_aminoacids serum_phospholipids 0.639 0.0206 no no no no up up L-Glutamine+blood 16:0/16:0-PI+blood -0.454135338 0 -0.55965812 serum_aminoacids serum_phospholipids 0.639 0.358 no no no no no no L-Glutamine+blood 16:0/16:1-PC+blood 0 0 -0.493333333 serum_aminoacids serum_phospholipids 0.639 0.00283 no no no up up no L-Glutamine+blood 16:0/16:1-PI+blood 0 0 -0.55965812 serum_aminoacids serum_phospholipids 0.639 0.262 no no no no no no L-Glutamine+blood 16:0/18:0-PS+blood -0.452631579 -0.514705882 0 serum_aminoacids serum_phospholipids 0.639 0.377 no no no no no no L-Glutamine+blood 16:0/18:2-PC+blood 0 0 0.56991453 serum_aminoacids serum_phospholipids 0.639 3.24E-06 no no no no up up L-Glutamine+blood 16:0/18:2-PI+blood -0.482706767 0 -0.502905983 serum_aminoacids serum_phospholipids 0.639 0.269 no no no no no no L-Glutamine+blood 16:0/20:4-PC+blood 0.493233083 0 0 serum_aminoacids serum_phospholipids 0.639 0.0262 no no no no up no L-Glutamine+blood 16:0/20:4-PI+blood -0.490225564 0 -0.532991453 serum_aminoacids serum_phospholipids 0.639 0.558 no no no no no no L-Glutamine+blood 16:0/22:0-PE+blood 0 0 0.511794872 serum_aminoacids serum_phospholipids 0.639 0.00839 no no no dn no up L-Glutamine+blood 16:0/22:6-PC+blood 0 0 0.630769231 serum_aminoacids serum_phospholipids 0.639 4.53E-05 no no no no up up L-Glutamine+blood 16:0/22:6-PE+blood 0 -0.551470588 0 serum_aminoacids serum_phospholipids 0.639 0.000934 no no no up up no L-Glutamine+blood 16:0+blood 0 0 -0.404444444 yes serum_aminoacids serum_fattyacid 0.639 0.00876 no no no up no no L-Glutamine+blood 16:1-LPC+blood 0 0 -0.441367521 serum_aminoacids serum_phospholipids 0.639 0.0241 no no no no up no L-Glutamine+blood 16:1/16:0-PC+blood 0 0 0.537094017 serum_aminoacids serum_phospholipids 0.639 0.0215 no no no no up up L-Glutamine+blood 18:0-LPC+blood -0.532330827 0 0 serum_aminoacids serum_phospholipids 0.639 0.554 no no no no no no L-Glutamine+blood 18:0-LPE+blood -0.482706767 0 0 serum_aminoacids serum_phospholipids 0.639 0.491 no no no no no no L-Glutamine+blood 18:0/18:0-PE+blood 0 0 -0.457094017 serum_aminoacids serum_phospholipids 0.639 0.00896 no no no up up no L-Glutamine+blood 18:0/18:0-PS+blood 0 -0.595588235 0 serum_aminoacids serum_phospholipids 0.639 0.00617 no no no no up no L-Glutamine+blood 18:0/18:1-PE+blood 0 0 -0.446153846 serum_aminoacids serum_phospholipids 0.639 0.00716 no no no up up no L-Glutamine+blood 18:0/18:1-PG+blood 0 0 -0.625982906 serum_aminoacids serum_phospholipids 0.639 0.000842 no no no no up no L-Glutamine+blood 18:0/18:2-PC+blood 0 0 0.584957265 serum_aminoacids serum_phospholipids 0.639 1.74E-06 no no no no up up L-Glutamine+blood 18:0/18:2-PI+blood -0.457142857 0 0 serum_aminoacids serum_phospholipids 0.639 0.179 no no no no no no L-Glutamine+blood 18:0/20:5-PC+blood 0 0 0.478974359 serum_aminoacids serum_phospholipids 0.639 0.17 no no no no no no L-Glutamine+blood 18:0/22:6-PC+blood 0 0 0.464615385 serum_aminoacids serum_phospholipids 0.639 0.0775 no no no no no up L-Glutamine+blood 18:0/22:6-PE+blood -0.452631579 -0.637254902 0 serum_aminoacids serum_phospholipids 0.639 0.00022 no no no up up no L-Glutamine+blood 18:0/22:6-PI+blood -0.54887218 0 0 serum_aminoacids serum_phospholipids 0.639 0.425 no no no no no no L-Glutamine+blood 18:0+blood 0 -0.634803922 0 serum_aminoacids serum_fattyacid 0.639 0.344 no no no no no no L-Glutamine+blood 18:1/16:0-PC+blood 0 0 0.596581197 serum_aminoacids serum_phospholipids 0.639 2.43E-05 no no no no up up L-Glutamine+blood 18:1/16:0-PE+blood 0 0 -0.459145299 serum_aminoacids serum_phospholipids 0.639 0.000182 no no no up up no L-Glutamine+blood 18:1/16:0-PI+blood -0.445112782 0 0 serum_aminoacids serum_phospholipids 0.639 0.793 no no no no no no L-Glutamine+blood 18:1/18:0-PC+blood 0 0 0.573333333 serum_aminoacids serum_phospholipids 0.639 1.83E-06 no no no no up up L-Glutamine+blood 18:1/18:0-PS+blood 0 -0.617647059 0 serum_aminoacids serum_phospholipids 0.639 0.193 no no no no no no L-Glutamine+blood 18:1/18:1-PE+blood 0 -0.512254902 0 serum_aminoacids serum_phospholipids 0.639 1.03E-05 no no no up up no L-Glutamine+blood 18:1/20:4-PC+blood 0 0 0.423589744 serum_aminoacids serum_phospholipids 0.639 0.582 no no no no no no L-Glutamine+blood 18:1/20:4-PE+blood 0 -0.629901961 0 serum_aminoacids serum_phospholipids 0.639 0.0578 no no no up no no L-Glutamine+blood 18:1/22:6-PE+blood 0 0 0.502222222 serum_aminoacids serum_phospholipids 0.639 0.0047 no no no no up no L-Glutamine+blood 18:2-LPA+blood 0 0.598039216 0 serum_aminoacids serum_phospholipids 0.639 0.00684 no no no dn no up L-Glutamine+blood 18:2/16:0-PC+blood 0 0 0.454358974 serum_aminoacids serum_phospholipids 0.639 8.67E-05 no no no no up up L-Glutamine+blood 18:3/16:0-PE+blood 0 0 -0.563076923 serum_aminoacids serum_phospholipids 0.639 0.00149 no no no up up no L-Glutamine+blood 18:3n6+blood 0 0 -0.424957265 serum_aminoacids serum_fattyacid 0.639 0.0463 no no no up no dn L-Glutamine+blood 20:0/20:4-PE+blood 0 0 -0.461880342 serum_aminoacids serum_phospholipids 0.639 0.00128 no no no up up no L-Glutamine+blood 20:1-LPC+blood 0 0 0.444786325 serum_aminoacids serum_phospholipids 0.639 0.217 no no no no no no L-Glutamine+blood 20:1/20:4-PC+blood 0 0 0.506324786 serum_aminoacids serum_phospholipids 0.639 0.0419 no no no no no up L-Glutamine+blood 20:1/20:4-PE+blood 0 -0.602941176 -0.420854701 serum_aminoacids serum_phospholipids 0.639 0.0042 no no no up up no L-Glutamine+blood 20:2/18:1-PE+blood -0.541353383 -0.514705882 -0.466666667 serum_aminoacids serum_phospholipids 0.639 0.00208 no no no up up no L-Glutamine+blood 20:3/16:0-PC+blood 0.50075188 0 0.406495726 serum_aminoacids serum_phospholipids 0.639 0.00405 no no no no up up L-Glutamine+blood 20:3/18:0-PC+blood 0 0 0.48991453 serum_aminoacids serum_phospholipids 0.639 0.296 no no no no no no L-Glutamine+blood 20:4/16:0-PE+blood 0 0 -0.451623932 serum_aminoacids serum_phospholipids 0.639 0.00529 no no no no up up L-Glutamine+blood 20:4/18:0-PE+blood 0 -0.62254902 0 serum_aminoacids serum_phospholipids 0.639 0.000755 no no no up up no L-Glutamine+blood 20:5/18:0-PC+blood 0 0 0.576068376 serum_aminoacids serum_phospholipids 0.639 3.97E-06 no no no no up up L-Glutamine+blood 24:1+blood 0.547368421 0 0.48991453 serum_aminoacids serum_fattyacid 0.639 0.00582 no no no no dn dn L-Glutamine+blood Adipocytokine signaling pathway 0.664912281 0 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Aldosterone synthesis and secretion 0 0 -0.450769231 serum_aminoacids kegg 0.639 NA no no no no up up L-Glutamine+blood Alistipes 0.526796204 0 0 serum_aminoacids Genus 0.639 0.0114 no no no no up no L-Glutamine+blood Amphetamine addiction 0 0 -0.47 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Asthma 0.473684211 0 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Betaine+blood 0 0.566176471 0.680683761 serum_aminoacids serum_choline 0.639 0.857 no no no no no no L-Glutamine+blood Biosynthesis of amino acids 0 0 0.445384615 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Blautia 0 0.593137255 0 acetate-producing serum_aminoacids Genus 0.639 1.36E-05 no no no up dn dn L-Glutamine+blood Butyricimonas 0 -0.505395297 0 butyrate-producing serum_aminoacids Genus 0.639 0.17 no no no no no no L-Glutamine+blood CA+blood 0 0 -0.421614831 serum_aminoacids serum_bileacids 0.639 0.606 no no no no no no L-Glutamine+blood Calcium signaling pathway 0 0 -0.469230769 serum_aminoacids kegg 0.639 NA no no no no up up L-Glutamine+blood capric acid C6+blood 0 0 0.427008547 serum_aminoacids serum_scfa 0.639 0.433 no no no no no no L-Glutamine+blood Carbon metabolism 0 0 0.566153846 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Cell cycle -0.622807018 0 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Central carbon metabolism in cancer -0.514035088 0 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Chemical carcinogenesis - receptor activation 0 0 -0.474615385 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Choline+blood 0 0.68872549 0 serum_aminoacids serum_choline 0.639 0.0395 no no no no up no L-Glutamine+blood Cocaine addiction 0 0 -0.468461538 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Cortisol synthesis and secretion 0 0 -0.561538462 serum_aminoacids kegg 0.639 NA no no no no no up L-Glutamine+blood Creatinine+blood 0.514285714 0.62254902 0.489230769 serum_aminoacids serum_choline 0.639 0.437 no no no no no no L-Glutamine+blood Cushing syndrome 0 0 -0.499230769 serum_aminoacids kegg 0.639 NA no no no no no up L-Glutamine+blood Cystine+blood 0.751879699 0 0.472136752 yes serum_aminoacids serum_aminoacids 0.639 0.00028 no no no up up no L-Glutamine+blood d18:1-14:0-SM+blood 0 0 -0.472136752 serum_aminoacids serum_phospholipids 0.639 0.94 no no no no no no L-Glutamine+blood d18:1-14:1-SM+blood -0.508270677 0 -0.536410256 serum_aminoacids serum_phospholipids 0.639 0.0952 no no no no dn no L-Glutamine+blood d18:1-16:1-SM+blood 0 0 -0.483760684 serum_aminoacids serum_phospholipids 0.639 0.2 no no no no no no L-Glutamine+blood DCA+blood 0 0 -0.432478632 serum_aminoacids serum_bileacids 0.639 0.122 no no no no no no L-Glutamine+blood DHA+blood -0.542857143 0 0 serum_aminoacids serum_ARA 0.639 0.872 no no no no no no L-Glutamine+blood DL-methionine sulfoxide+blood 0 0.600490196 0 serum_aminoacids serum_aminoacids 0.639 0.302 no no no no no no L-Glutamine+blood DMG+blood 0 0 0.539145299 serum_aminoacids serum_choline 0.639 0.909 no no no no no no L-Glutamine+blood DPA+blood -0.470676692 0 0 serum_aminoacids serum_ARA 0.639 0.519 no no no no no no L-Glutamine+blood Endocrine and other factor-regulated calcium reabsorption 0 0 -0.443846154 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Endocrine resistance 0 0 -0.508461538 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Estrogen signaling pathway -0.726315789 0 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Ethanolamine+blood 0.545864662 0 0 serum_aminoacids serum_aminoacids 0.639 0.122 no no no up no no L-Glutamine+blood Fc gamma R-mediated phagocytosis 0 0 0.433846154 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Gap junction 0 0 -0.422307692 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood GLCA+blood 0.501987068 0 0 serum_aminoacids serum_bileacids 0.639 0.319 no no no no no no L-Glutamine+blood Glioma 0 -0.511764706 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Glycine+blood 0.529323308 0.524509804 0.606153846 serum_aminoacids serum_aminoacids 0.639 0.00408 no no no dn no up L-Glutamine+blood Glycolysis / Gluconeogenesis 0 0 0.403846154 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood GPC+blood 0 0.776960784 0 serum_aminoacids serum_choline 0.639 0.00427 no no no no up up L-Glutamine+blood "Growth hormone synthesis, secretion and action" 0 0 -0.509230769 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Hepatitis C 0 0.511764706 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood heptanoic acid C7+blood 0 0 0.44 serum_aminoacids serum_mcfa 0.639 8.27E-11 no no no dn dn no L-Glutamine+blood Hypotaurine+blood 0 0.519607843 0 serum_aminoacids serum_aminoacids 0.639 0.933 no no no no no no L-Glutamine+blood Inflammatory mediator regulation of TRP channels 0 0 -0.46 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Influenza A 0.5 0 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Insulin secretion 0 0 -0.492307692 yes serum_aminoacids kegg 0.639 NA no no no no up up L-Glutamine+blood Kaposi sarcoma-associated herpesvirus infection 0.487719298 0 0 serum_aminoacids kegg 0.639 NA no no no no no dn L-Glutamine+blood L-Alanine+blood 0.590977444 0 0 yes serum_aminoacids serum_aminoacids 0.639 0.00138 no no no up up no L-Glutamine+blood L-Arginine+blood 0.527819549 0 0.667692308 serum_aminoacids serum_aminoacids 0.639 0.316 no no no no no no L-Glutamine+blood L-Asparagine+blood 0.745864662 0.666666667 0.753162393 serum_aminoacids serum_aminoacids 0.639 0.784 no no no no no no L-Glutamine+blood L-Aspartic acid+blood 0.606015038 0.556372549 0 yes serum_aminoacids serum_aminoacids 0.639 0.0226 no no no up up no L-Glutamine+blood L-Citrulline+blood 0.560902256 0 0.424273504 serum_aminoacids serum_aminoacids 0.639 0.534 no no no no no no L-Glutamine+blood L-Glutamic acid+blood 0.50075188 0.534313725 0 yes serum_aminoacids serum_aminoacids 0.639 6.20E-05 no no no up up no L-Glutamine+blood Long-term depression 0 0 -0.450769231 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Longevity regulating pathway - multiple species -0.705263158 0 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Lysosome 0 0 0.413076923 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Malaria 0.514035088 0 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood MAPK signaling pathway -0.50877193 0 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Measles 0 0.729411765 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Melanogenesis 0 0 -0.440769231 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Morphine addiction 0 0 -0.407692308 serum_aminoacids kegg 0.639 NA no no no no up up L-Glutamine+blood Non-alcoholic fatty liver disease 0 0 -0.437692308 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Oocyte meiosis -0.459649123 0 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Pancreatic cancer 0 0 -0.434615385 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Pancreatic secretion 0 0 -0.472307692 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Prevotella 0 -0.614601316 0 acetate-producing serum_aminoacids Genus 0.639 0.287 no no no no no no L-Glutamine+blood Primary immunodeficiency -0.636842105 0 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Progesterone-mediated oocyte maturation -0.501754386 0 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Regulation of lipolysis in adipocytes 0 0 -0.456923077 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Small cell lung cancer 0 0 -0.432307692 serum_aminoacids kegg 0.639 NA no no no no no up L-Glutamine+blood Spliceosome -0.471929825 0 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Th1 and Th2 cell differentiation 0.598245614 0 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Th17 cell differentiation 0.514035088 0.514705882 0 serum_aminoacids kegg 0.639 NA no no no no no no L-Glutamine+blood Vasopressin-regulated water reabsorption 0 0 -0.410769231 serum_aminoacids kegg 0.639 NA no no no no no no L-Histidine+blood 13-HODE+blood 0.484210526 0 0 serum_aminoacids serum_ARA 0.109 0.32 no no no no no no L-Histidine+blood 14:0/18:2-PC+blood 0 0 -0.455726496 serum_aminoacids serum_phospholipids 0.109 0.102 no no no no up no L-Histidine+blood 14:0/20:4-PC+blood 0 0 -0.462564103 serum_aminoacids serum_phospholipids 0.109 0.486 no no no no no no L-Histidine+blood 14:1/18:2-PG+blood 0 0 -0.42017094 serum_aminoacids serum_phospholipids 0.109 0.00259 no no no no up up L-Histidine+blood 16:0-LPC+blood 0.467669173 0 0 serum_aminoacids serum_phospholipids 0.109 0.00456 no no no up up no L-Histidine+blood 16:0/14:0-PC+blood 0.497744361 0 0 serum_aminoacids serum_phospholipids 0.109 0.0206 no no no no up up L-Histidine+blood 16:0/18:0-PS+blood 0 -0.821078431 0 serum_aminoacids serum_phospholipids 0.109 0.377 no no no no no no L-Histidine+blood 16:0/18:2-PC+blood 0.533834586 0 0.422222222 serum_aminoacids serum_phospholipids 0.109 3.24E-06 no no no no up up L-Histidine+blood 16:0/18:2-PI+blood 0 0 -0.414017094 serum_aminoacids serum_phospholipids 0.109 0.269 no no no no no no L-Histidine+blood 16:0/18:3-PC+blood 0 0 -0.446837607 serum_aminoacids serum_phospholipids 0.109 0.00216 no no no no up up L-Histidine+blood 16:0/20:3-PC+blood 0.511278195 0 0 serum_aminoacids serum_phospholipids 0.109 5.43E-06 no no no no up up L-Histidine+blood 16:0/20:4-PC+blood 0.455639098 0 0 serum_aminoacids serum_phospholipids 0.109 0.0262 no no no no up no L-Histidine+blood 16:0/20:4-PI+blood 0 0 -0.610940171 serum_aminoacids serum_phospholipids 0.109 0.558 no no no no no no L-Histidine+blood 16:0/20:5-PC+blood 0 -0.644607843 0 serum_aminoacids serum_phospholipids 0.109 0.628 no no no no no no L-Histidine+blood 16:0/22:6-PE+blood 0 -0.68872549 0 serum_aminoacids serum_phospholipids 0.109 0.000934 no no no up up no L-Histidine+blood 16:1/16:0-PC+blood 0.538345865 0 0 serum_aminoacids serum_phospholipids 0.109 0.0215 no no no no up up L-Histidine+blood 16:1/18:2-PG+blood 0.511278195 0 0 serum_aminoacids serum_phospholipids 0.109 1.40E-08 no no no no up up L-Histidine+blood 18:0-LPE+blood -0.529323308 0 0 serum_aminoacids serum_phospholipids 0.109 0.491 no no no no no no L-Histidine+blood 18:0/18:0-PE+blood -0.603007519 0 0 serum_aminoacids serum_phospholipids 0.109 0.00896 no no no up up no L-Histidine+blood 18:0/18:0-PS+blood 0 -0.862745098 0 serum_aminoacids serum_phospholipids 0.109 0.00617 no no no no up no L-Histidine+blood 18:0/18:1-PE+blood -0.603007519 0 0 serum_aminoacids serum_phospholipids 0.109 0.00716 no no no up up no L-Histidine+blood 18:0/18:1-PG+blood 0 0 -0.406495726 serum_aminoacids serum_phospholipids 0.109 0.000842 no no no no up no L-Histidine+blood 18:0/20:3-PI+blood 0.45112782 0 0 serum_aminoacids serum_phospholipids 0.109 0.377 no no no no no no L-Histidine+blood 18:0/22:6-PE+blood 0 -0.803921569 0 serum_aminoacids serum_phospholipids 0.109 0.00022 no no no up up no L-Histidine+blood 18:0/22:6-PI+blood 0 -0.593137255 0 serum_aminoacids serum_phospholipids 0.109 0.425 no no no no no no L-Histidine+blood 18:1-LPC+blood 0 0.539215686 0 serum_aminoacids serum_phospholipids 0.109 0.179 no no no no no no L-Histidine+blood 18:1-LPE+blood -0.494736842 0 0 serum_aminoacids serum_phospholipids 0.109 0.117 no no no no no no L-Histidine+blood 18:1/16:0-PC+blood 0.488721805 0 0.439316239 serum_aminoacids serum_phospholipids 0.109 2.43E-05 no no no no up up L-Histidine+blood 18:1/16:0-PE+blood -0.506766917 0 0 serum_aminoacids serum_phospholipids 0.109 0.000182 no no no up up no L-Histidine+blood 18:1/18:0-PE+blood 0 0 -0.405128205 serum_aminoacids serum_phospholipids 0.109 1.39E-06 no no no up up no L-Histidine+blood 18:1/18:0-PS+blood 0 -0.605392157 0 serum_aminoacids serum_phospholipids 0.109 0.193 no no no no no no L-Histidine+blood 18:1/18:1-PE+blood 0 0 -0.424957265 serum_aminoacids serum_phospholipids 0.109 1.03E-05 no no no up up no L-Histidine+blood 18:1/20:3-PC+blood 0 0.629901961 0 serum_aminoacids serum_phospholipids 0.109 0.00872 no no no no up up L-Histidine+blood 18:1/20:4-PE+blood 0 -0.676470588 0 serum_aminoacids serum_phospholipids 0.109 0.0578 no no no up no no L-Histidine+blood 18:3/16:0-PE+blood 0 0 -0.465982906 serum_aminoacids serum_phospholipids 0.109 0.00149 no no no up up no L-Histidine+blood 18:3n6+blood -0.553383459 0 -0.426324786 serum_aminoacids serum_fattyacid 0.109 0.0463 no no no up no dn L-Histidine+blood 20:0/20:4-PE+blood 0 0 -0.455726496 serum_aminoacids serum_phospholipids 0.109 0.00128 no no no up up no L-Histidine+blood 20:1-LPA+blood 0.466165414 0 0.443418803 serum_aminoacids serum_phospholipids 0.109 0.0187 no no no dn dn no L-Histidine+blood 20:1-LPC+blood 0 0.519607843 0 serum_aminoacids serum_phospholipids 0.109 0.217 no no no no no no L-Histidine+blood 20:1/20:4-PE+blood 0 -0.598039216 -0.446837607 serum_aminoacids serum_phospholipids 0.109 0.0042 no no no up up no L-Histidine+blood 20:2-LPC+blood 0.518796992 0 0 serum_aminoacids serum_phospholipids 0.109 0.119 no no no no no up L-Histidine+blood 20:2/18:1-PE+blood 0 0 -0.457094017 serum_aminoacids serum_phospholipids 0.109 0.00208 no no no up up no L-Histidine+blood 20:3/16:0-PC+blood 0.45112782 0 0 serum_aminoacids serum_phospholipids 0.109 0.00405 no no no no up up L-Histidine+blood 20:4/16:0-PE+blood -0.460150376 0 0 serum_aminoacids serum_phospholipids 0.109 0.00529 no no no no up up L-Histidine+blood 20:4/18:0-PE+blood 0 -0.629901961 0 serum_aminoacids serum_phospholipids 0.109 0.000755 no no no up up no L-Histidine+blood 20:5n3+blood 0 -0.605392157 0 serum_aminoacids serum_fattyacid 0.109 0.988 no no no no no no L-Histidine+blood 22:1-LPA+blood 0.478195489 0 0 serum_aminoacids serum_phospholipids 0.109 0.00373 no no no no up up L-Histidine+blood 22:6n3+blood 0 -0.529411765 0 serum_aminoacids serum_fattyacid 0.109 0.792 no no no no no no L-Histidine+blood 8-HETE+blood 0 0.5 0 serum_aminoacids serum_ARA 0.109 0.741 no no no no no no L-Histidine+blood Acetic acid+stool 0 0.681818182 0 yes serum_aminoacids stool_scfa 0.109 0.0656 no no no dn no no L-Histidine+blood Adipocytokine signaling pathway 0 0.55 0 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood Adrenergic signaling in cardiomyocytes 0 0 -0.404615385 serum_aminoacids kegg 0.109 NA no no no no no up L-Histidine+blood Alzheimer disease 0 0 -0.411538462 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood Amphetamine addiction 0 0 -0.456153846 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood Amyotrophic lateral sclerosis 0 0 -0.455384615 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood Betaine+blood 0 0 0.593162393 serum_aminoacids serum_choline 0.109 0.857 no no no no no no L-Histidine+blood Butyric acid+stool 0 0.618181818 0 yes serum_aminoacids stool_scfa 0.109 0.102 no no no dn no no L-Histidine+blood Butyricimonas 0 0 0.471656671 butyrate-producing serum_aminoacids Genus 0.109 0.17 no no no no no no L-Histidine+blood Calcium signaling pathway 0 0 -0.449230769 serum_aminoacids kegg 0.109 NA no no no no up up L-Histidine+blood cAMP signaling pathway 0 0.567647059 0 yes serum_aminoacids kegg 0.109 NA no no no no up up L-Histidine+blood Cardiac muscle contraction 0 0 -0.433846154 serum_aminoacids kegg 0.109 NA no no no no no up L-Histidine+blood Choline+blood 0.593984962 0.620098039 0.403760684 serum_aminoacids serum_choline 0.109 0.0395 no no no no up no L-Histidine+blood Chronic myeloid leukemia 0 0.597058824 0 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood Clostridium 0 -0.594283918 0 serum_aminoacids Genus 0.109 0.925 no no no no no no L-Histidine+blood Cocaine addiction 0 0 -0.413846154 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood Creatinine+blood 0.639097744 0 0.563760684 serum_aminoacids serum_choline 0.109 0.437 no no no no no no L-Histidine+blood Cysteine+blood 0.733834586 0 0.567863248 yes serum_aminoacids serum_aminoacids 0.109 1.81E-07 no no no dn up up L-Histidine+blood Cystine+blood 0 0.490196078 0 yes serum_aminoacids serum_aminoacids 0.109 0.00028 no no no up up no L-Histidine+blood Cytosolic DNA-sensing pathway 0 0.605882353 0 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood d18:0-24:1-SM+blood -0.469172932 0 0 serum_aminoacids serum_phospholipids 0.109 0.0609 no no no no dn dn L-Histidine+blood d18:1-14:0-SM+blood 0 0 -0.452307692 serum_aminoacids serum_phospholipids 0.109 0.94 no no no no no no L-Histidine+blood d18:1-14:1-SM+blood 0 0 -0.481025641 serum_aminoacids serum_phospholipids 0.109 0.0952 no no no no dn no L-Histidine+blood d18:1-16:1-SM+blood 0 0 -0.478974359 serum_aminoacids serum_phospholipids 0.109 0.2 no no no no no no L-Histidine+blood DCA+blood 0 0.526960784 0 serum_aminoacids serum_bileacids 0.109 0.122 no no no no no no L-Histidine+blood DL-methionine sulfoxide+blood 0 0.593137255 0 serum_aminoacids serum_aminoacids 0.109 0.302 no no no no no no L-Histidine+blood Ethanolamine+blood 0 0.666666667 0.441367521 serum_aminoacids serum_aminoacids 0.109 0.122 no no no up no no L-Histidine+blood Gap junction 0 0 -0.432307692 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood GCDCA+stool 0 0 -0.593984962 yes serum_aminoacids stool_bileacids 0.109 0.0471 no no no no dn no L-Histidine+blood GDCA+stool 0 0 -0.472892103 serum_aminoacids stool_bileacids 0.109 0.656 no no no no no no L-Histidine+blood Glycine+blood 0 0.529411765 0 serum_aminoacids serum_aminoacids 0.109 0.00408 no no no dn no up L-Histidine+blood GPC+blood 0 0.50245098 0 serum_aminoacids serum_choline 0.109 0.00427 no no no no up up L-Histidine+blood HDCA+blood 0.518101712 0 0 serum_aminoacids serum_bileacids 0.109 0.483 no no no no no no L-Histidine+blood Hepatitis C 0 0.594117647 0 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood heptanoic acid C7+blood 0 0.509803922 0 serum_aminoacids serum_mcfa 0.109 8.27E-11 no no no dn dn no L-Histidine+blood Hypotaurine+blood 0 0.710784314 0 serum_aminoacids serum_aminoacids 0.109 0.933 no no no no no no L-Histidine+blood Insulin resistance 0 0.520588235 0 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood iso-DCA+blood 0.505263158 0 0 serum_aminoacids serum_bileacids 0.109 0.38 no no no no no no L-Histidine+blood iso-heptanoic acid C7+blood -0.479699248 0 0 serum_aminoacids serum_mcfa 0.109 0.00256 no no no up up no L-Histidine+blood Kaposi sarcoma-associated herpesvirus infection 0 0.555882353 0 serum_aminoacids kegg 0.109 NA no no no no no dn L-Histidine+blood L-Arginine+blood 0.586466165 0 0.575384615 serum_aminoacids serum_aminoacids 0.109 0.316 no no no no no no L-Histidine+blood L-Asparagine+blood 0 0.81127451 0.672478632 serum_aminoacids serum_aminoacids 0.109 0.784 no no no no no no L-Histidine+blood L-Citrulline+blood 0 0.615196078 0.505641026 serum_aminoacids serum_aminoacids 0.109 0.534 no no no no no no L-Histidine+blood L-Glutamine+blood 0 0.691176471 0.587692308 serum_aminoacids serum_aminoacids 0.109 0.639 no no no no no no L-Histidine+blood Long-term depression 0 0 -0.417692308 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood Melanogenesis 0 0 -0.416923077 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood Neurotrophin signaling pathway 0 0.514705882 0 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood Non-alcoholic fatty liver disease 0 0 -0.483076923 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood Pancreatic secretion 0 0 -0.406923077 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.505882353 0 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood Prostate cancer 0 0.552941176 0 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood Renin secretion 0 0 -0.423076923 serum_aminoacids kegg 0.109 NA no no no no no no L-Histidine+blood Small cell lung cancer 0 0.544117647 0 serum_aminoacids kegg 0.109 NA no no no no no up L-Homocystine+blood 11-HETE+blood 0.444687802 0 0 serum_aminoacids serum_ARA 0.197 0.464 no no no no no no L-Homocystine+blood 12-ketoDCA+blood 0 0.546668169 0 serum_aminoacids serum_bileacids 0.197 0.517 no no no no no no L-Homocystine+blood 18:0-LPC+blood 0 0 0.433162393 serum_aminoacids serum_phospholipids 0.197 0.554 no no no no no no L-Homocystine+blood 18:0/18:1-PI+blood 0 -0.485294118 0 serum_aminoacids serum_phospholipids 0.197 0.599 no no no no no no L-Homocystine+blood 18:0/20:3-PI+blood 0 -0.62745098 0 serum_aminoacids serum_phospholipids 0.197 0.377 no no no no no no L-Homocystine+blood 18:1-LPE+blood 0.568421053 0 0 serum_aminoacids serum_phospholipids 0.197 0.117 no no no no no no L-Homocystine+blood 18:1/18:2-PI+blood 0 0 0.44957265 serum_aminoacids serum_phospholipids 0.197 0.0164 no no no dn no up L-Homocystine+blood 18:2/18:2-PS+blood 0 -0.490196078 0 serum_aminoacids serum_phospholipids 0.197 0.00674 no no no up up no L-Homocystine+blood 18:3n3+blood 0 0 0.429059829 serum_aminoacids serum_fattyacid 0.197 0.291 no no no no no no L-Homocystine+blood 20:0-LPE+blood 0 0 0.444102564 serum_aminoacids serum_phospholipids 0.197 0.0615 no no no no no up L-Homocystine+blood 20:1-LPA+blood -0.446616541 0 0 serum_aminoacids serum_phospholipids 0.197 0.0187 no no no dn dn no L-Homocystine+blood 20:1-LPE+blood 0.457142857 0 0 serum_aminoacids serum_phospholipids 0.197 0.465 no no no no no no L-Homocystine+blood 20:3n6+blood 0 0 -0.461880342 serum_aminoacids serum_fattyacid 0.197 0.0884 no no no up no no L-Homocystine+blood 20:4/16:0-PE+blood 0 0 0.465982906 serum_aminoacids serum_phospholipids 0.197 0.00529 no no no no up up L-Homocystine+blood 22:6n3+blood 0 0 -0.431111111 serum_aminoacids serum_fattyacid 0.197 0.792 no no no no no no L-Homocystine+blood 24:0+blood -0.460150376 0 -0.550769231 serum_aminoacids serum_fattyacid 0.197 0.034 no no no dn no up L-Homocystine+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 -0.618181818 0 serum_aminoacids stool_cometabolism 0.197 0.33 no no no no no no L-Homocystine+blood 4-hydroxybenzoic acid+stool -0.60989011 0 0 serum_aminoacids stool_cometabolism 0.197 0.0536 no no no no dn no L-Homocystine+blood 8-HETE+blood -0.554887218 0 0 serum_aminoacids serum_ARA 0.197 0.741 no no no no no no L-Homocystine+blood Acetic acid+stool -0.576923077 0 0 yes serum_aminoacids stool_scfa 0.197 0.0656 no no no dn no no L-Homocystine+blood Adrenergic signaling in cardiomyocytes 0.587719298 0.511764706 0 serum_aminoacids kegg 0.197 NA no no no no no up L-Homocystine+blood Aldosterone synthesis and secretion 0.471929825 0.567647059 0 serum_aminoacids kegg 0.197 NA no no no no up up L-Homocystine+blood Allograft rejection 0 -0.611764706 -0.450769231 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Alzheimer disease 0.650877193 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Amyotrophic lateral sclerosis 0.607017544 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Antigen processing and presentation 0 -0.614705882 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Autoimmune thyroid disease 0 -0.611764706 -0.450769231 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Autophagy - animal 0.510526316 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Bacterial invasion of epithelial cells -0.556140351 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Bacteroides -0.461654135 0 0 LPS-producing serum_aminoacids Genus 0.197 0.000267 no no no dn dn up L-Homocystine+blood Biosynthesis of amino acids -0.596491228 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Blautia 0 -0.517156863 0 acetate-producing serum_aminoacids Genus 0.197 1.36E-05 no no no up dn dn L-Homocystine+blood CA+stool 0 -0.672727273 0 serum_aminoacids stool_bileacids 0.197 0.827 no no no no no no L-Homocystine+blood Calcium signaling pathway 0.573684211 0.555882353 0 serum_aminoacids kegg 0.197 NA no no no no up up L-Homocystine+blood cAMP signaling pathway 0.628070175 0 0 yes serum_aminoacids kegg 0.197 NA no no no no up up L-Homocystine+blood Carbon metabolism -0.712280702 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Cardiac muscle contraction 0.635087719 0 0 serum_aminoacids kegg 0.197 NA no no no no no up L-Homocystine+blood CDCA+stool 0 -0.709090909 0 serum_aminoacids stool_bileacids 0.197 0.663 no no no no no no L-Homocystine+blood Cell adhesion molecules 0 -0.670588235 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Cellular senescence 0 -0.505882353 -0.421538462 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Chagas disease 0.531578947 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Chemical carcinogenesis - receptor activation 0.503508772 0.670588235 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Choline metabolism in cancer 0.556140351 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Colorectal cancer 0.475438596 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Cushing syndrome 0 0.638235294 0 serum_aminoacids kegg 0.197 NA no no no no no up L-Homocystine+blood d18:1-20:0-SM+blood -0.476691729 0 0 serum_aminoacids serum_phospholipids 0.197 0.933 no no no no no no L-Homocystine+blood Diabetic cardiomyopathy 0.633333333 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Dopaminergic synapse 0.501754386 0.570588235 0 serum_aminoacids kegg 0.197 NA no no no no up no L-Homocystine+blood DPA+blood 0 -0.534313725 0 serum_aminoacids serum_ARA 0.197 0.519 no no no no no no L-Homocystine+blood Eggerthella 0 -0.507149988 0 serum_aminoacids Genus 0.197 0.912 no no no no no no L-Homocystine+blood Endocrine resistance 0.501754386 0.705882353 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Endocytosis 0 -0.614705882 -0.480769231 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Epstein-Barr virus infection 0 -0.6 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Fc gamma R-mediated phagocytosis -0.463157895 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Ferroptosis 0 0.517647059 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood FoxO signaling pathway 0 0 0.536153846 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Gap junction 0 0.5 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood GCA+stool 0 -0.772727273 0 serum_aminoacids stool_bileacids 0.197 0.0809 no no no no no no L-Homocystine+blood GLCA+blood 0 0 0.468769477 serum_aminoacids serum_bileacids 0.197 0.319 no no no no no no L-Homocystine+blood Glycolysis / Gluconeogenesis -0.568421053 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood GnRH signaling pathway 0 0.723529412 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood GPC+blood -0.536842105 0 0.463931624 serum_aminoacids serum_choline 0.197 0.00427 no no no no up up L-Homocystine+blood Graft-versus-host disease 0 -0.611764706 -0.425384615 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood "Growth hormone synthesis, secretion and action" 0.477192982 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood GUDCA+stool 0 0.66421334 0 yes serum_aminoacids stool_bileacids 0.197 0.0085 no no no no dn no L-Homocystine+blood HCA+stool -0.554945055 0 -0.590977444 serum_aminoacids stool_bileacids 0.197 0.155 no no no no no no L-Homocystine+blood HDCA+blood 0 0.578536772 0 serum_aminoacids serum_bileacids 0.197 0.483 no no no no no no L-Homocystine+blood Herpes simplex virus 1 infection 0 -0.688235294 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Human cytomegalovirus infection 0 -0.544117647 0 serum_aminoacids kegg 0.197 NA no no no no no dn L-Homocystine+blood Human immunodeficiency virus 1 infection 0 -0.594117647 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Human papillomavirus infection 0 -0.511764706 -0.41 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Human T-cell leukemia virus 1 infection 0 -0.632352941 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Huntington disease 0.647368421 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood iso-LCA+blood 0 0.590784383 0 serum_aminoacids serum_bileacids 0.197 0.507 no no no no no no L-Homocystine+blood iso-LCA+stool 0 0.7 0 serum_aminoacids stool_bileacids 0.197 0.72 no no no no no no L-Homocystine+blood L-Citrulline+blood 0.466165414 0 0 serum_aminoacids serum_aminoacids 0.197 0.534 no no no no no no L-Homocystine+blood LCA+stool 0 0.645454545 0 serum_aminoacids stool_bileacids 0.197 0.314 no no no no no no L-Homocystine+blood Long-term depression 0.557894737 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Longevity regulating pathway 0.573684211 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Longevity regulating pathway - multiple species 0 -0.685294118 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Methanobrevibacter 0 0 0.400056655 serum_aminoacids Genus 0.197 0.629 no no no no no no L-Homocystine+blood Mineral absorption 0 0.611764706 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Mitophagy - animal 0.466666667 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Morphine addiction 0 0.758823529 0 serum_aminoacids kegg 0.197 NA no no no no up up L-Homocystine+blood mRNA surveillance pathway 0.466666667 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Natural killer cell mediated cytotoxicity -0.554385965 -0.597058824 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Neuroactive ligand-receptor interaction 0 -0.508823529 0 serum_aminoacids kegg 0.197 NA no no no up up up L-Homocystine+blood Neurotrophin signaling pathway 0.521052632 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Neutrophil extracellular trap formation -0.496491228 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Non-alcoholic fatty liver disease 0.668421053 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood nutriCA+stool -0.571428571 0 0 serum_aminoacids stool_bileacids 0.197 0.481 no no no no no no L-Homocystine+blood Oscillospira 0.562406015 0 0 LPS-producing serum_aminoacids Genus 0.197 0.62 no no no no no no L-Homocystine+blood Oxidative phosphorylation 0.589473684 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Pancreatic cancer 0 -0.523529412 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Pancreatic secretion 0.501754386 0.714705882 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Paraprevotella -0.499849457 0 0 serum_aminoacids Genus 0.197 0.118 no no no no no no L-Homocystine+blood "Parathyroid hormone synthesis, secretion and action" 0.575438596 0.570588235 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Parkinson disease 0.610526316 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Pathogenic Escherichia coli infection -0.526315789 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Pathways in cancer 0.519298246 0 0.468461538 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Pathways of neurodegeneration - multiple diseases 0.60877193 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Platinum drug resistance 0 0 0.489230769 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Prion disease 0.561403509 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Prostate cancer 0.584210526 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Relaxin signaling pathway 0.60877193 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Roseburia -0.503759398 0 0 butyrate-producing serum_aminoacids Genus 0.197 0.495 no no no no no no L-Homocystine+blood Ruminococcus 0 0 -0.517948718 acetate-producing serum_aminoacids Genus 0.197 0.335 no no no no no no L-Homocystine+blood Salmonella infection -0.640350877 -0.552941176 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Serotonergic synapse 0 0.585294118 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Signaling pathways regulating pluripotency of stem cells 0.605263158 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Thermogenesis 0.542105263 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Thyroid hormone synthesis 0 0.729411765 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Tight junction -0.480701754 0 0 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Transcriptional misregulation in cancer 0 0 0.5 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood Type I diabetes mellitus 0 -0.611764706 -0.441538462 serum_aminoacids kegg 0.197 NA no no no no no no L-Homocystine+blood UDCA+stool 0 -0.754545455 -0.612030075 serum_aminoacids stool_bileacids 0.197 0.266 no no no no no no L-Homocystine+blood Viral myocarditis 0 -0.638235294 -0.459230769 serum_aminoacids kegg 0.197 NA no no no no no no L-Isoleucine+blood 12-HEPE+blood 0 -0.493977261 0 yes serum_aminoacids serum_ARA 5.47E-06 0.312 up up no no no no L-Isoleucine+blood 15-HETE+blood 0 0 -0.50716447 yes serum_aminoacids serum_ARA 5.47E-06 0.819 up up no no no no L-Isoleucine+blood 16:0/20:5-PC+blood 0 -0.642156863 0 yes serum_aminoacids serum_phospholipids 5.47E-06 0.628 up up no no no no L-Isoleucine+blood 16:0/22:0-PE+blood 0 -0.487745098 0 yes serum_aminoacids serum_phospholipids 5.47E-06 0.00839 up up no dn no up L-Isoleucine+blood 18:0-LPA+blood 0 0.507352941 0 yes serum_aminoacids serum_phospholipids 5.47E-06 0.0725 up up no no dn no L-Isoleucine+blood 18:0/18:1-PI+blood 0 0.517156863 0 yes serum_aminoacids serum_phospholipids 5.47E-06 0.599 up up no no no no L-Isoleucine+blood 18:1-LPE+blood -0.502255639 0 0 yes serum_aminoacids serum_phospholipids 5.47E-06 0.117 up up no no no no L-Isoleucine+blood 18:3/18:2-PC+blood 0 0 -0.413333333 yes serum_aminoacids serum_phospholipids 5.47E-06 0.0394 up up no no no up L-Isoleucine+blood 20:1-LPA+blood 0 0.534313725 0 yes serum_aminoacids serum_phospholipids 5.47E-06 0.0187 up up no dn dn no L-Isoleucine+blood 20:4-LPE+blood 0 0 -0.416068376 yes serum_aminoacids serum_phospholipids 5.47E-06 0.552 up up no no no no L-Isoleucine+blood 20:4/16:0-PE+blood -0.454135338 0 0 yes serum_aminoacids serum_phospholipids 5.47E-06 0.00529 up up no no up up L-Isoleucine+blood 20:5n3+blood 0 -0.605392157 0 yes serum_aminoacids serum_fattyacid 5.47E-06 0.988 up up no no no no L-Isoleucine+blood 22:1-LPA+blood 0.454135338 0 0 yes serum_aminoacids serum_phospholipids 5.47E-06 0.00373 up up no no up up L-Isoleucine+blood 22:6-LPC+blood 0 0 0.502222222 yes serum_aminoacids serum_phospholipids 5.47E-06 0.127 up up no no no up L-Isoleucine+blood 22:6n3+blood 0 0 0.401025641 yes serum_aminoacids serum_fattyacid 5.47E-06 0.792 up up no no no no L-Isoleucine+blood Adrenergic signaling in cardiomyocytes 0 0 -0.468461538 yes serum_aminoacids kegg 5.47E-06 NA up up no no no up L-Isoleucine+blood Aldosterone synthesis and secretion 0 0 -0.421538462 yes serum_aminoacids kegg 5.47E-06 NA up up no no up up L-Isoleucine+blood Amphetamine addiction 0 0 -0.515384615 yes serum_aminoacids kegg 5.47E-06 NA up up no no no no L-Isoleucine+blood Anaerostipes 0 0 -0.42762078 yes butyrate-producing serum_aminoacids Genus 5.47E-06 0.568 up up no no no no L-Isoleucine+blood Axon guidance 0 0 -0.403076923 yes serum_aminoacids kegg 5.47E-06 NA up up no no up up L-Isoleucine+blood Betaine+blood 0 0 0.433846154 yes serum_aminoacids serum_choline 5.47E-06 0.857 up up no no no no L-Isoleucine+blood Blautia 0 0.634803922 0 yes acetate-producing serum_aminoacids Genus 5.47E-06 1.36E-05 up up no up dn dn L-Isoleucine+blood Butyricimonas 0 -0.490157248 0 yes butyrate-producing serum_aminoacids Genus 5.47E-06 0.17 up up no no no no L-Isoleucine+blood CA+blood -0.510718351 0 0 yes serum_aminoacids serum_bileacids 5.47E-06 0.606 up up no no no no L-Isoleucine+blood CDCA+stool 0 0.654545455 0 yes serum_aminoacids stool_bileacids 5.47E-06 0.663 up up no no no no L-Isoleucine+blood Chemical carcinogenesis - receptor activation 0 -0.594117647 0 yes serum_aminoacids kegg 5.47E-06 NA up up no no no no L-Isoleucine+blood Choline+blood 0.452631579 0 0.485811966 yes serum_aminoacids serum_choline 5.47E-06 0.0395 up up no no up no L-Isoleucine+blood Cholinergic synapse 0 -0.735294118 0 yes serum_aminoacids kegg 5.47E-06 NA up up no no no no L-Isoleucine+blood Clostridium 0 0.523605249 0 yes serum_aminoacids Genus 5.47E-06 0.925 up up no no no no L-Isoleucine+blood Creatinine+blood 0.557894737 0.68872549 0.498803419 yes serum_aminoacids serum_choline 5.47E-06 0.437 up up no no no no L-Isoleucine+blood Cysteine+blood 0 0 0.424273504 yes yes serum_aminoacids serum_aminoacids 5.47E-06 1.81E-07 up up no dn up up L-Isoleucine+blood Cystine+blood 0 0.678921569 0 yes yes serum_aminoacids serum_aminoacids 5.47E-06 0.00028 up up no up up no L-Isoleucine+blood d18:0-16:0-SM+blood -0.485714286 0 0 yes serum_aminoacids serum_phospholipids 5.47E-06 0.202 up up no no no no L-Isoleucine+blood d18:0-18:3-SM+blood 0 0 -0.455726496 yes serum_aminoacids serum_phospholipids 5.47E-06 0.0879 up up no no dn no L-Isoleucine+blood d18:0-24:1-SM+blood -0.494736842 0 0 yes serum_aminoacids serum_phospholipids 5.47E-06 0.0609 up up no no dn dn L-Isoleucine+blood d18:1-14:1-SM+blood 0 -0.507352941 -0.405811966 yes serum_aminoacids serum_phospholipids 5.47E-06 0.0952 up up no no dn no L-Isoleucine+blood d18:1-16:0-SM+blood -0.478195489 0 0 yes serum_aminoacids serum_phospholipids 5.47E-06 0.14 up up no no no no L-Isoleucine+blood d18:1-16:1-SM+blood -0.544360902 0 -0.448888889 yes serum_aminoacids serum_phospholipids 5.47E-06 0.2 up up no no no no L-Isoleucine+blood d18:1-22:1-SM+blood -0.523308271 0 0 yes serum_aminoacids serum_phospholipids 5.47E-06 0.222 up up no no no no L-Isoleucine+blood decanoic acid C10+blood 0 0.580882353 0 yes serum_aminoacids serum_mcfa 5.47E-06 6.64E-11 up up no dn dn no L-Isoleucine+blood DL-methionine sulfoxide+blood 0 0.68872549 0.439316239 yes serum_aminoacids serum_aminoacids 5.47E-06 0.302 up up no no no no L-Isoleucine+blood DMG+blood 0 0 0.483760684 yes serum_aminoacids serum_choline 5.47E-06 0.909 up up no no no no L-Isoleucine+blood Estrogen signaling pathway 0 0 -0.400769231 yes serum_aminoacids kegg 5.47E-06 NA up up no no no no L-Isoleucine+blood Ethanolamine+blood 0 0 0.59042735 yes serum_aminoacids serum_aminoacids 5.47E-06 0.122 up up no up no no L-Isoleucine+blood Gap junction 0 0 -0.430769231 yes serum_aminoacids kegg 5.47E-06 NA up up no no no no L-Isoleucine+blood GCDCA+stool 0 0.7 -0.571428571 yes yes serum_aminoacids stool_bileacids 5.47E-06 0.0471 up up no no dn no L-Isoleucine+blood GDCA+stool -0.582417582 0.76537784 -0.548193393 yes serum_aminoacids stool_bileacids 5.47E-06 0.656 up up no no no no L-Isoleucine+blood Glucagon signaling pathway 0 0 -0.404615385 yes serum_aminoacids kegg 5.47E-06 NA up up no no no no L-Isoleucine+blood GnRH signaling pathway 0 0 -0.456153846 yes serum_aminoacids kegg 5.47E-06 NA up up no no no no L-Isoleucine+blood HCA+blood -0.471660975 0 0 yes serum_aminoacids serum_bileacids 5.47E-06 0.544 up up no no no no L-Isoleucine+blood heptanoic acid C7+blood 0 0 0.504957265 yes serum_aminoacids serum_mcfa 5.47E-06 8.27E-11 up up no dn dn no L-Isoleucine+blood Inflammatory mediator regulation of TRP channels 0 0 -0.432307692 yes serum_aminoacids kegg 5.47E-06 NA up up no no no no L-Isoleucine+blood Intestinal immune network for IgA production 0 0 -0.434615385 yes serum_aminoacids kegg 5.47E-06 NA up up no no no no L-Isoleucine+blood isobutyric acid C4+blood 0.562406015 0 0 yes serum_aminoacids serum_scfa 5.47E-06 0.0151 up up no up up no L-Isoleucine+blood isocapric acid iso-C6+blood 0.44962406 0 0 yes serum_aminoacids serum_scfa 5.47E-06 0.0458 up up no no no dn L-Isoleucine+blood Kaposi sarcoma-associated herpesvirus infection 0 0.508823529 0 yes serum_aminoacids kegg 5.47E-06 NA up up no no no dn L-Isoleucine+blood L-Arginine+blood 0.529323308 0 0 yes serum_aminoacids serum_aminoacids 5.47E-06 0.316 up up no no no no L-Isoleucine+blood L-Asparagine+blood 0 0.526960784 0.414017094 yes serum_aminoacids serum_aminoacids 5.47E-06 0.784 up up no no no no L-Isoleucine+blood L-Citrulline+blood 0 0 0.44957265 yes serum_aminoacids serum_aminoacids 5.47E-06 0.534 up up no no no no L-Isoleucine+blood L-Glutamic acid+blood 0.464661654 0.642156863 0 yes yes serum_aminoacids serum_aminoacids 5.47E-06 6.20E-05 up up no up up no L-Isoleucine+blood L-Glutamine+blood 0 0.507352941 0.40991453 yes serum_aminoacids serum_aminoacids 5.47E-06 0.639 up up no no no no L-Isoleucine+blood L-Histidine+blood 0.697744361 0.509803922 0.673162393 yes serum_aminoacids serum_aminoacids 5.47E-06 0.109 up up no no no no L-Isoleucine+blood Long-term depression 0 0 -0.406923077 yes serum_aminoacids kegg 5.47E-06 NA up up no no no no L-Isoleucine+blood Long-term potentiation 0 0 -0.422307692 yes serum_aminoacids kegg 5.47E-06 NA up up no no no up L-Isoleucine+blood Mineral absorption 0.473684211 0 0 yes serum_aminoacids kegg 5.47E-06 NA up up no no no no L-Isoleucine+blood Parabacteroides 0 0 0.515301769 yes serum_aminoacids Genus 5.47E-06 4.19E-05 up up no no up up L-Isoleucine+blood Phenylacetic acid+stool 0 -0.727272727 0 yes serum_aminoacids stool_cometabolism 5.47E-06 0.785 up up no no no no L-Isoleucine+blood Proteasome 0 0 0.427692308 yes serum_aminoacids kegg 5.47E-06 NA up up no no no no L-Leucine+blood 15-HETE+blood 0 0 -0.423909016 yes serum_aminoacids serum_ARA 3.22E-05 0.819 up up no no no no L-Leucine+blood 16:0-LPC+blood 0 0.531862745 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.00456 up up no up up no L-Leucine+blood 16:1+blood -0.520300752 0 0 yes yes serum_aminoacids serum_fattyacid 3.22E-05 0.0186 up up no no no dn L-Leucine+blood 18:0/18:0-PC+blood 0 -0.492647059 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.426 up up no no no no L-Leucine+blood 18:0/18:1-PC+blood 0 -0.507352941 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.393 up up no no no no L-Leucine+blood 18:0/20:2-PC+blood 0 -0.656862745 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.733 up up no no no no L-Leucine+blood 18:0/20:3-PC+blood 0 -0.50245098 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.0682 up up no no up no L-Leucine+blood 18:1/20:4-PE+blood 0 0 -0.448205128 yes serum_aminoacids serum_phospholipids 3.22E-05 0.0578 up up no up no no L-Leucine+blood 18:1+blood -0.514285714 0 0 yes yes serum_aminoacids serum_fattyacid 3.22E-05 0.00202 up up no up no dn L-Leucine+blood 18:3n3+blood 0 0.507352941 0 yes serum_aminoacids serum_fattyacid 3.22E-05 0.291 up up no no no no L-Leucine+blood 20:0-LPE+blood 0 -0.495098039 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.0615 up up no no no up L-Leucine+blood 20:0+blood 0 -0.524509804 0 yes yes serum_aminoacids serum_fattyacid 3.22E-05 0.000278 up up no dn no up L-Leucine+blood 20:1+blood 0 0 0.419487179 yes yes serum_aminoacids serum_fattyacid 3.22E-05 2.56E-05 up up no dn dn dn L-Leucine+blood 20:2-LPE+blood 0 -0.571078431 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.177 up up no no no no L-Leucine+blood 20:2/18:0-PC+blood 0 -0.526960784 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.0427 up up no no up no L-Leucine+blood Acetic acid+stool 0.56043956 0 0 yes yes serum_aminoacids stool_scfa 3.22E-05 0.0656 up up no dn no no L-Leucine+blood Akkermansia -0.479607038 0 0 yes acetate-producing serum_aminoacids Genus 3.22E-05 0.23 up up no no no no L-Leucine+blood Antigen processing and presentation -0.529824561 0 0 yes serum_aminoacids kegg 3.22E-05 NA up up no no no no L-Leucine+blood Axon guidance 0 -0.6 0 yes serum_aminoacids kegg 3.22E-05 NA up up no no up up L-Leucine+blood Betaine+blood 0 0.600490196 0 yes serum_aminoacids serum_choline 3.22E-05 0.857 up up no no no no L-Leucine+blood Choline+blood 0 0.588235294 0 yes serum_aminoacids serum_choline 3.22E-05 0.0395 up up no no up no L-Leucine+blood Cholinergic synapse -0.456140351 0 0 yes serum_aminoacids kegg 3.22E-05 NA up up no no no no L-Leucine+blood Creatinine+blood 0 0.693627451 0.416752137 yes serum_aminoacids serum_choline 3.22E-05 0.437 up up no no no no L-Leucine+blood Cysteine+blood 0 0 0.40991453 yes yes serum_aminoacids serum_aminoacids 3.22E-05 1.81E-07 up up no dn up up L-Leucine+blood d18:0-16:0-SM+blood -0.505263158 0 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.202 up up no no no no L-Leucine+blood d18:0-24:1-SM+blood -0.467669173 0 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.0609 up up no no dn dn L-Leucine+blood d18:1-14:1-SM+blood 0 -0.553921569 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.0952 up up no no dn no L-Leucine+blood d18:1-16:0-SM+blood -0.487218045 0 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.14 up up no no no no L-Leucine+blood d18:1-20:0-SM+blood -0.50075188 0 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.933 up up no no no no L-Leucine+blood d18:1-20:1-SM+blood -0.532330827 0 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.0992 up up no no no no L-Leucine+blood d18:1-22:0-SM+blood 0 -0.575980392 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.522 up up no no no no L-Leucine+blood d18:1-22:1-SM+blood -0.515789474 0 0 yes serum_aminoacids serum_phospholipids 3.22E-05 0.222 up up no no no no L-Leucine+blood DMG+blood 0 0 0.608205128 yes serum_aminoacids serum_choline 3.22E-05 0.909 up up no no no no L-Leucine+blood Epstein-Barr virus infection -0.550877193 0 0 yes serum_aminoacids kegg 3.22E-05 NA up up no no no no L-Leucine+blood Ethanolamine+blood 0 0 0.474188034 yes serum_aminoacids serum_aminoacids 3.22E-05 0.122 up up no up no no L-Leucine+blood Faecalibacterium 0.503759398 0 0 yes butyrate-producing serum_aminoacids Genus 3.22E-05 0.0039 up up no no dn dn L-Leucine+blood Gastric cancer 0 -0.520588235 0 yes serum_aminoacids kegg 3.22E-05 NA up up no no no no L-Leucine+blood GCA+blood 0.44962406 0 0 yes yes serum_aminoacids serum_bileacids 3.22E-05 0.16 up up no no no no L-Leucine+blood GPC+blood 0 0.551470588 0 yes serum_aminoacids serum_choline 3.22E-05 0.00427 up up no no up up L-Leucine+blood heptanoic acid C7+blood 0 0 0.537777778 yes serum_aminoacids serum_mcfa 3.22E-05 8.27E-11 up up no dn dn no L-Leucine+blood Herpes simplex virus 1 infection -0.6 0 0 yes serum_aminoacids kegg 3.22E-05 NA up up no no no no L-Leucine+blood Human cytomegalovirus infection -0.612280702 0 0 yes serum_aminoacids kegg 3.22E-05 NA up up no no no dn L-Leucine+blood Human immunodeficiency virus 1 infection -0.577192982 0 0 yes serum_aminoacids kegg 3.22E-05 NA up up no no no no L-Leucine+blood Human T-cell leukemia virus 1 infection -0.512280702 0 0 yes serum_aminoacids kegg 3.22E-05 NA up up no no no no L-Leucine+blood Intestinal immune network for IgA production 0 0 -0.409230769 yes serum_aminoacids kegg 3.22E-05 NA up up no no no no L-Leucine+blood iso-DCA+blood 0 0 0.474188034 yes serum_aminoacids serum_bileacids 3.22E-05 0.38 up up no no no no L-Leucine+blood isobutyric acid C4+blood 0.545864662 0 0 yes serum_aminoacids serum_scfa 3.22E-05 0.0151 up up no up up no L-Leucine+blood L-Alanine+blood 0 0.637254902 0 yes yes serum_aminoacids serum_aminoacids 3.22E-05 0.00138 up up no up up no L-Leucine+blood L-Arginine+blood 0 0.509803922 0.446837607 yes serum_aminoacids serum_aminoacids 3.22E-05 0.316 up up no no no no L-Leucine+blood L-Asparagine+blood 0 0.571078431 0 yes serum_aminoacids serum_aminoacids 3.22E-05 0.784 up up no no no no L-Leucine+blood L-Citrulline+blood 0 0 0.624615385 yes serum_aminoacids serum_aminoacids 3.22E-05 0.534 up up no no no no L-Leucine+blood L-Glutamic acid+blood 0 0.585784314 0 yes yes serum_aminoacids serum_aminoacids 3.22E-05 6.20E-05 up up no up up no L-Leucine+blood L-Histidine+blood 0 0 0.534358974 yes serum_aminoacids serum_aminoacids 3.22E-05 0.109 up up no no no no L-Leucine+blood L-Isoleucine+blood 0.745864662 0.691176471 0.79008547 yes yes serum_aminoacids serum_aminoacids 3.22E-05 5.47E-06 up up no up up no L-Leucine+blood Lachnospira 0.49924812 0 0 yes butyrate-producing serum_aminoacids Genus 3.22E-05 0.279 up up no no no no L-Leucine+blood Methanobrevibacter 0 0 0.50673843 yes serum_aminoacids Genus 3.22E-05 0.629 up up no no no no L-Leucine+blood Parabacteroides 0 -0.529411765 0.47803044 yes serum_aminoacids Genus 3.22E-05 4.19E-05 up up no no up up L-Leucine+blood Prevotella 0 0 0.453065624 yes acetate-producing serum_aminoacids Genus 3.22E-05 0.287 up up no no no no L-Leucine+blood Viral protein interaction with cytokine and cytokine receptor -0.456140351 0 0 yes serum_aminoacids kegg 3.22E-05 NA up up no no no no L-Lysine+blood 12-ketoDCA+blood 0 0 -0.401415311 yes serum_aminoacids serum_bileacids 0.0107 0.517 no up no no no no L-Lysine+blood 14:0/18:0-PC+blood -0.527819549 0 0 yes serum_aminoacids serum_phospholipids 0.0107 0.00289 no up no up up no L-Lysine+blood 14:0/20:4-PC+blood -0.523308271 0 0 yes serum_aminoacids serum_phospholipids 0.0107 0.486 no up no no no no L-Lysine+blood 16:0/14:0-PC+blood 0 0 0.440683761 yes serum_aminoacids serum_phospholipids 0.0107 0.0206 no up no no up up L-Lysine+blood 16:0/16:1-PI+blood -0.52481203 0 0 yes serum_aminoacids serum_phospholipids 0.0107 0.262 no up no no no no L-Lysine+blood 16:0/18:1-PC+blood 0 0 0.411965812 yes serum_aminoacids serum_phospholipids 0.0107 6.15E-07 no up no up up up L-Lysine+blood 16:0/18:2-PC+blood 0 0.524509804 0.554871795 yes serum_aminoacids serum_phospholipids 0.0107 3.24E-06 no up no no up up L-Lysine+blood 16:0/20:3-PC+blood 0 0.495098039 0 yes serum_aminoacids serum_phospholipids 0.0107 5.43E-06 no up no no up up L-Lysine+blood 16:0/20:5-PC+blood 0 -0.495098039 0 yes serum_aminoacids serum_phospholipids 0.0107 0.628 no up no no no no L-Lysine+blood 16:0/22:6-PC+blood 0.455639098 0 0.447521368 yes serum_aminoacids serum_phospholipids 0.0107 4.53E-05 no up no no up up L-Lysine+blood 16:1/16:0-PC+blood 0 0 0.488547009 yes serum_aminoacids serum_phospholipids 0.0107 0.0215 no up no no up up L-Lysine+blood 18:0/16:0-PC+blood 0 0 0.401025641 yes serum_aminoacids serum_phospholipids 0.0107 9.64E-07 no up no up up up L-Lysine+blood 18:0/18:0-PE+blood 0 0 -0.410598291 yes serum_aminoacids serum_phospholipids 0.0107 0.00896 no up no up up no L-Lysine+blood 18:0/18:2-PC+blood 0 0 0.499487179 yes serum_aminoacids serum_phospholipids 0.0107 1.74E-06 no up no no up up L-Lysine+blood 18:0/20:5-PC+blood 0.484210526 0 0 yes serum_aminoacids serum_phospholipids 0.0107 0.17 no up no no no no L-Lysine+blood 18:0/22:6-PC+blood 0 0 0.455726496 yes serum_aminoacids serum_phospholipids 0.0107 0.0775 no up no no no up L-Lysine+blood 18:0+blood 0 0 0.534358974 yes serum_aminoacids serum_fattyacid 0.0107 0.344 no up no no no no L-Lysine+blood 18:1/16:0-PC+blood 0 0.509803922 0.548717949 yes serum_aminoacids serum_phospholipids 0.0107 2.43E-05 no up no no up up L-Lysine+blood 18:1/18:0-PC+blood 0 0 0.478290598 yes serum_aminoacids serum_phospholipids 0.0107 1.83E-06 no up no no up up L-Lysine+blood 18:1/18:2-PE+blood 0 0 -0.503589744 yes serum_aminoacids serum_phospholipids 0.0107 0.000293 no up no up up no L-Lysine+blood 18:1/20:4-PE+blood 0 -0.612745098 0 yes serum_aminoacids serum_phospholipids 0.0107 0.0578 no up no up no no L-Lysine+blood 18:2/18:2-PS+blood -0.502255639 0 0 yes serum_aminoacids serum_phospholipids 0.0107 0.00674 no up no up up no L-Lysine+blood 18:3/16:0-PE+blood -0.497744361 -0.504901961 0 yes serum_aminoacids serum_phospholipids 0.0107 0.00149 no up no up up no L-Lysine+blood 18:3/18:2-PC+blood 0 0 -0.497435897 yes serum_aminoacids serum_phospholipids 0.0107 0.0394 no up no no no up L-Lysine+blood 18:3n6+blood -0.631578947 0 0 yes serum_aminoacids serum_fattyacid 0.0107 0.0463 no up no up no dn L-Lysine+blood 20:1/20:4-PC+blood 0 0 0.503589744 yes serum_aminoacids serum_phospholipids 0.0107 0.0419 no up no no no up L-Lysine+blood 20:1/20:4-PE+blood 0 -0.504901961 0 yes serum_aminoacids serum_phospholipids 0.0107 0.0042 no up no up up no L-Lysine+blood 20:3/16:0-PC+blood 0 0 0.403076923 yes serum_aminoacids serum_phospholipids 0.0107 0.00405 no up no no up up L-Lysine+blood 20:4/16:0-PE+blood 0 0 -0.514529915 yes serum_aminoacids serum_phospholipids 0.0107 0.00529 no up no no up up L-Lysine+blood 20:4/18:0-PE+blood 0 -0.490196078 0 yes serum_aminoacids serum_phospholipids 0.0107 0.000755 no up no up up no L-Lysine+blood 22:1-LPA+blood 0 0.485294118 0 yes serum_aminoacids serum_phospholipids 0.0107 0.00373 no up no no up up L-Lysine+blood Acute myeloid leukemia 0.547368421 0 0 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Adherens junction 0 0 -0.484615385 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood AGE-RAGE signaling pathway in diabetic complications 0.480701754 0 0 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Alzheimer disease 0 0 -0.593076923 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Amyotrophic lateral sclerosis 0 0 -0.576923077 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Arginine and proline metabolism 0 0 0.45 yes serum_aminoacids kegg 0.0107 NA no up no no up no L-Lysine+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.523076923 yes serum_aminoacids kegg 0.0107 NA no up no no up up L-Lysine+blood Bacterial invasion of epithelial cells 0 0 -0.448461538 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Blautia 0 0.526960784 0 yes acetate-producing serum_aminoacids Genus 0.0107 1.36E-05 no up no up dn dn L-Lysine+blood Butyricimonas 0 0 0.500284241 yes butyrate-producing serum_aminoacids Genus 0.0107 0.17 no up no no no no L-Lysine+blood CA+stool 0 0 -0.497744361 yes serum_aminoacids stool_bileacids 0.0107 0.827 no up no no no no L-Lysine+blood Cardiac muscle contraction 0 0 -0.641538462 yes serum_aminoacids kegg 0.0107 NA no up no no no up L-Lysine+blood CDCA+stool 0 0 -0.448120301 yes serum_aminoacids stool_bileacids 0.0107 0.663 no up no no no no L-Lysine+blood Cell adhesion molecules 0 0 -0.418461538 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Cell cycle -0.484210526 0 0 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Choline+blood 0.490225564 0 0 yes serum_aminoacids serum_choline 0.0107 0.0395 no up no no up no L-Lysine+blood Creatinine+blood 0.796992481 0 0 yes serum_aminoacids serum_choline 0.0107 0.437 no up no no no no L-Lysine+blood Cysteine+blood 0.458646617 0 0.561709402 yes yes serum_aminoacids serum_aminoacids 0.0107 1.81E-07 no up no dn up up L-Lysine+blood Cystine+blood 0.667669173 0.742647059 0.486495726 yes yes serum_aminoacids serum_aminoacids 0.0107 0.00028 no up no up up no L-Lysine+blood Cytokine-cytokine receptor interaction 0 0 -0.445384615 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood d18:0-18:3-SM+blood 0 0 -0.401025641 yes serum_aminoacids serum_phospholipids 0.0107 0.0879 no up no no dn no L-Lysine+blood d18:1-14:0-SM+blood 0 0 -0.419487179 yes serum_aminoacids serum_phospholipids 0.0107 0.94 no up no no no no L-Lysine+blood d18:1-14:1-SM+blood -0.57443609 -0.50245098 -0.422905983 yes serum_aminoacids serum_phospholipids 0.0107 0.0952 no up no no dn no L-Lysine+blood d18:1-16:1-SM+blood 0 0 -0.459145299 yes serum_aminoacids serum_phospholipids 0.0107 0.2 no up no no no no L-Lysine+blood Diabetic cardiomyopathy 0 0 -0.580769231 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Dilated cardiomyopathy 0 0 -0.605384615 yes serum_aminoacids kegg 0.0107 NA no up no no up up L-Lysine+blood DL-methionine sulfoxide+blood 0 0.541666667 0 yes serum_aminoacids serum_aminoacids 0.0107 0.302 no up no no no no L-Lysine+blood DMG+blood 0 0 0.433846154 yes serum_aminoacids serum_choline 0.0107 0.909 no up no no no no L-Lysine+blood Estrogen signaling pathway 0 0 -0.511538462 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Ethanolamine+blood 0.479699248 0.558823529 0.518632479 yes serum_aminoacids serum_aminoacids 0.0107 0.122 no up no up no no L-Lysine+blood Fc epsilon RI signaling pathway 0.642105263 0 0 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Focal adhesion 0 0 -0.601538462 yes serum_aminoacids kegg 0.0107 NA no up no no up up L-Lysine+blood Gastric acid secretion 0 0 -0.521538462 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood GDCA+stool 0 0.838270968 0 yes serum_aminoacids stool_bileacids 0.0107 0.656 no up no no no no L-Lysine+blood "Glycine, serine and threonine metabolism" -0.487719298 0 0 yes serum_aminoacids kegg 0.0107 NA no up no no up no L-Lysine+blood GPC+blood 0 0.487745098 0 yes serum_aminoacids serum_choline 0.0107 0.00427 no up no no up up L-Lysine+blood Hippo signaling pathway 0 0 -0.625384615 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Huntington disease 0 0 -0.542307692 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Hypertrophic cardiomyopathy 0 0 -0.506153846 yes serum_aminoacids kegg 0.0107 NA no up no no up up L-Lysine+blood Influenza A 0.514035088 0 0 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood iso-DCA+blood 0 0 0.466666667 yes serum_aminoacids serum_bileacids 0.0107 0.38 no up no no no no L-Lysine+blood L-2-Aminobutyric acid+blood 0.566917293 0 0.442735043 yes yes serum_aminoacids serum_aminoacids 0.0107 0.000328 no up no up up no L-Lysine+blood L-Alanine+blood 0.523308271 0.492647059 0 yes yes serum_aminoacids serum_aminoacids 0.0107 0.00138 no up no up up no L-Lysine+blood L-Arginine+blood 0.538345865 0.595588235 0.539145299 yes serum_aminoacids serum_aminoacids 0.0107 0.316 no up no no no no L-Lysine+blood L-Asparagine+blood 0.593984962 0.615196078 0 yes serum_aminoacids serum_aminoacids 0.0107 0.784 no up no no no no L-Lysine+blood L-Aspartic acid+blood 0 0 0.507692308 yes yes serum_aminoacids serum_aminoacids 0.0107 0.0226 no up no up up no L-Lysine+blood L-Glutamic acid+blood 0.70075188 0.705882353 0.582222222 yes yes serum_aminoacids serum_aminoacids 0.0107 6.20E-05 no up no up up no L-Lysine+blood L-Glutamine+blood 0.577443609 0.593137255 0 yes serum_aminoacids serum_aminoacids 0.0107 0.639 no up no no no no L-Lysine+blood L-Histidine+blood 0.609022556 0.620098039 0.591111111 yes serum_aminoacids serum_aminoacids 0.0107 0.109 no up no no no no L-Lysine+blood L-Isoleucine+blood 0.636090226 0.74754902 0.56991453 yes yes serum_aminoacids serum_aminoacids 0.0107 5.47E-06 no up no up up no L-Lysine+blood L-Leucine+blood 0 0.519607843 0 yes yes serum_aminoacids serum_aminoacids 0.0107 3.22E-05 no up no up up no L-Lysine+blood L-Tryptophan+stool 0 0 0.44962406 yes serum_aminoacids stool_cometabolism 0.0107 0.557 no up no no no no L-Lysine+blood L-Tyrosine+stool 0 0 0.464661654 yes serum_aminoacids stool_cometabolism 0.0107 0.44 no up no no no no L-Lysine+blood Legionellosis -0.594736842 0 0 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Leishmaniasis -0.535087719 0 0 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Leukocyte transendothelial migration 0 0 -0.403846154 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Non-alcoholic fatty liver disease 0 0 -0.585384615 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Oxidative phosphorylation 0 0 -0.586923077 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Phospholipase D signaling pathway 0.643859649 0 0 yes serum_aminoacids kegg 0.0107 NA no up no no up up L-Lysine+blood Platelet activation 0 0 -0.476923077 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Prion disease 0 0 -0.679230769 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Prolactin signaling pathway 0.510526316 0 0 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Purine metabolism 0 0 0.438461538 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Regulation of actin cytoskeleton 0 0 -0.473076923 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Retrograde endocannabinoid signaling 0 0 -0.506923077 yes serum_aminoacids kegg 0.0107 NA no up no no no up L-Lysine+blood RNA transport -0.594736842 0 0 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Thermogenesis 0 0 -0.533846154 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Thyroid hormone signaling pathway 0 0 -0.512307692 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Lysine+blood Viral protein interaction with cytokine and cytokine receptor 0 0 -0.508461538 yes serum_aminoacids kegg 0.0107 NA no up no no no no L-Methionine+blood 12-HEPE+blood 0.575704432 -0.576306805 0 serum_aminoacids serum_ARA 0.626 0.312 no no no no no no L-Methionine+blood 13-HODE+blood 0.472180451 0 0 serum_aminoacids serum_ARA 0.626 0.32 no no no no no no L-Methionine+blood 14:0/20:4-PC+blood -0.446616541 0 -0.425641026 serum_aminoacids serum_phospholipids 0.626 0.486 no no no no no no L-Methionine+blood 16:0/18:0-PS+blood -0.554887218 -0.512254902 0 serum_aminoacids serum_phospholipids 0.626 0.377 no no no no no no L-Methionine+blood 16:0/18:1-PE+blood -0.557894737 0 0 serum_aminoacids serum_phospholipids 0.626 0.000107 no no no up up no L-Methionine+blood 16:0/18:2-PC+blood 0.467669173 0 0 serum_aminoacids serum_phospholipids 0.626 3.24E-06 no no no no up up L-Methionine+blood 16:0/20:3-PC+blood 0.476691729 0 0 serum_aminoacids serum_phospholipids 0.626 5.43E-06 no no no no up up L-Methionine+blood 16:0/20:5-PC+blood 0 -0.583333333 0 serum_aminoacids serum_phospholipids 0.626 0.628 no no no no no no L-Methionine+blood 16:0/22:6-PE+blood -0.52481203 -0.522058824 0 serum_aminoacids serum_phospholipids 0.626 0.000934 no no no up up no L-Methionine+blood 16:1/18:2-PG+blood 0.457142857 0 0 serum_aminoacids serum_phospholipids 0.626 1.40E-08 no no no no up up L-Methionine+blood 18:0-LPA+blood 0 0.536764706 0 serum_aminoacids serum_phospholipids 0.626 0.0725 no no no no dn no L-Methionine+blood 18:0/16:0-PC+blood 0 0 0.402393162 serum_aminoacids serum_phospholipids 0.626 9.64E-07 no no no up up up L-Methionine+blood 18:0/18:0-PE+blood -0.631578947 0 0 serum_aminoacids serum_phospholipids 0.626 0.00896 no no no up up no L-Methionine+blood 18:0/18:0-PS+blood -0.505263158 0 0 serum_aminoacids serum_phospholipids 0.626 0.00617 no no no no up no L-Methionine+blood 18:0/18:1-PE+blood -0.62406015 0 0 serum_aminoacids serum_phospholipids 0.626 0.00716 no no no up up no L-Methionine+blood 18:0/18:2-PC+blood 0.452631579 0 0 serum_aminoacids serum_phospholipids 0.626 1.74E-06 no no no no up up L-Methionine+blood 18:0/20:3-PI+blood 0.593984962 0 0 serum_aminoacids serum_phospholipids 0.626 0.377 no no no no no no L-Methionine+blood 18:1/16:0-PE+blood -0.660150376 0 0 serum_aminoacids serum_phospholipids 0.626 0.000182 no no no up up no L-Methionine+blood 18:1/16:1-PE+blood -0.586466165 0 0 serum_aminoacids serum_phospholipids 0.626 0.000184 no no no up up no L-Methionine+blood 18:1/18:0-PS+blood 0 -0.551470588 0 serum_aminoacids serum_phospholipids 0.626 0.193 no no no no no no L-Methionine+blood 18:1/18:1-PE+blood -0.521804511 0 0 serum_aminoacids serum_phospholipids 0.626 1.03E-05 no no no up up no L-Methionine+blood 18:1/18:2-PE+blood -0.464661654 0 0 serum_aminoacids serum_phospholipids 0.626 0.000293 no no no up up no L-Methionine+blood 18:2-LPA+blood 0 0.544117647 0 serum_aminoacids serum_phospholipids 0.626 0.00684 no no no dn no up L-Methionine+blood 18:2/18:2-PS+blood -0.50075188 0 0 serum_aminoacids serum_phospholipids 0.626 0.00674 no no no up up no L-Methionine+blood 18:3/16:0-PE+blood -0.714285714 0 0 serum_aminoacids serum_phospholipids 0.626 0.00149 no no no up up no L-Methionine+blood 18:3n6+blood -0.583458647 0 -0.425641026 serum_aminoacids serum_fattyacid 0.626 0.0463 no no no up no dn L-Methionine+blood 20:0+blood 0 -0.487745098 0 yes serum_aminoacids serum_fattyacid 0.626 0.000278 no no no dn no up L-Methionine+blood 20:1-LPA+blood 0 0.531862745 0 serum_aminoacids serum_phospholipids 0.626 0.0187 no no no dn dn no L-Methionine+blood 20:1-LPE+blood 0 -0.526960784 0 serum_aminoacids serum_phospholipids 0.626 0.465 no no no no no no L-Methionine+blood 20:2-LPC+blood 0.6 0 0 serum_aminoacids serum_phospholipids 0.626 0.119 no no no no no up L-Methionine+blood 20:2-LPE+blood 0 -0.598039216 0 serum_aminoacids serum_phospholipids 0.626 0.177 no no no no no no L-Methionine+blood 20:2/18:1-PE+blood -0.584962406 0 0 serum_aminoacids serum_phospholipids 0.626 0.00208 no no no up up no L-Methionine+blood 20:4-LPA+blood 0 0.509803922 0 serum_aminoacids serum_phospholipids 0.626 0.398 no no no no no no L-Methionine+blood 20:4-LPE+blood 0 0 -0.40034188 serum_aminoacids serum_phospholipids 0.626 0.552 no no no no no no L-Methionine+blood 20:5n3+blood 0 -0.56127451 0 serum_aminoacids serum_fattyacid 0.626 0.988 no no no no no no L-Methionine+blood 22:1-LPA+blood 0 0.617647059 0 serum_aminoacids serum_phospholipids 0.626 0.00373 no no no no up up L-Methionine+blood Adrenergic signaling in cardiomyocytes 0.614035088 0 0 serum_aminoacids kegg 0.626 NA no no no no no up L-Methionine+blood AGE-RAGE signaling pathway in diabetic complications 0.60877193 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Autophagy - animal 0 0 0.443076923 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Biosynthesis of amino acids -0.584210526 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Blautia 0 0.512254902 0 acetate-producing serum_aminoacids Genus 0.626 1.36E-05 no no no up dn dn L-Methionine+blood Breast cancer 0.49122807 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Butyricimonas 0.485584373 -0.594283918 0 butyrate-producing serum_aminoacids Genus 0.626 0.17 no no no no no no L-Methionine+blood Calcium signaling pathway 0.564912281 0 0 serum_aminoacids kegg 0.626 NA no no no no up up L-Methionine+blood cAMP signaling pathway 0.561403509 0 0 yes serum_aminoacids kegg 0.626 NA no no no no up up L-Methionine+blood Carbon metabolism -0.661403509 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood CDCA+blood 0 0 -0.408547009 serum_aminoacids serum_bileacids 0.626 0.506 no no no no no no L-Methionine+blood cGMP-PKG signaling pathway 0.477192982 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Choline metabolism in cancer 0.519298246 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Choline+blood 0.460150376 0 0 serum_aminoacids serum_choline 0.626 0.0395 no no no no up no L-Methionine+blood Clostridium 0 0.501532896 0 serum_aminoacids Genus 0.626 0.925 no no no no no no L-Methionine+blood Colorectal cancer 0.505263158 -0.576470588 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Creatinine+blood 0.666165414 0.620098039 0 serum_aminoacids serum_choline 0.626 0.437 no no no no no no L-Methionine+blood Cysteine+blood 0.476691729 0 0.44957265 yes serum_aminoacids serum_aminoacids 0.626 1.81E-07 no no no dn up up L-Methionine+blood Cystine+blood 0 0.566176471 0 yes serum_aminoacids serum_aminoacids 0.626 0.00028 no no no up up no L-Methionine+blood Cytokine-cytokine receptor interaction 0 0 -0.418461538 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood d18:0-18:3-SM+blood 0 0 -0.573333333 serum_aminoacids serum_phospholipids 0.626 0.0879 no no no no dn no L-Methionine+blood d18:1-14:0-SM+blood -0.445112782 0 0 serum_aminoacids serum_phospholipids 0.626 0.94 no no no no no no L-Methionine+blood d18:1-14:1-SM+blood -0.514285714 0 -0.55008547 serum_aminoacids serum_phospholipids 0.626 0.0952 no no no no dn no L-Methionine+blood d18:1-16:1-SM+blood 0 0 -0.497435897 serum_aminoacids serum_phospholipids 0.626 0.2 no no no no no no L-Methionine+blood d18:1-20:0-SM+blood -0.497744361 0 0 serum_aminoacids serum_phospholipids 0.626 0.933 no no no no no no L-Methionine+blood decanoic acid C10+blood 0.494736842 0 0 serum_aminoacids serum_mcfa 0.626 6.64E-11 no no no dn dn no L-Methionine+blood DL-methionine sulfoxide+blood 0 0.490196078 0.445470085 serum_aminoacids serum_aminoacids 0.626 0.302 no no no no no no L-Methionine+blood DMG+blood 0 0.590686275 0.447521368 serum_aminoacids serum_choline 0.626 0.909 no no no no no no L-Methionine+blood Dopaminergic synapse 0.459649123 0 0 serum_aminoacids kegg 0.626 NA no no no no up no L-Methionine+blood ErbB signaling pathway 0.559649123 -0.547058824 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Ethanolamine+blood 0 0 0.556923077 serum_aminoacids serum_aminoacids 0.626 0.122 no no no up no no L-Methionine+blood Fc epsilon RI signaling pathway 0.635087719 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Gap junction 0 0 -0.446923077 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Gastric cancer 0 -0.538235294 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood GCA+stool -0.593406593 0 0 serum_aminoacids stool_bileacids 0.626 0.0809 no no no no no no L-Methionine+blood GDCA+stool 0 0.656038149 0 serum_aminoacids stool_bileacids 0.626 0.656 no no no no no no L-Methionine+blood Glioma 0.571929825 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Glycolysis / Gluconeogenesis -0.659649123 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood GPC+blood 0 0.485294118 0 serum_aminoacids serum_choline 0.626 0.00427 no no no no up up L-Methionine+blood "Growth hormone synthesis, secretion and action" 0.531578947 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Hypotaurine+blood 0 0 0.638974359 serum_aminoacids serum_aminoacids 0.626 0.933 no no no no no no L-Methionine+blood Inflammatory mediator regulation of TRP channels 0.457894737 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Intestinal immune network for IgA production 0.457894737 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood iso-heptanoic acid C7+blood -0.464661654 0 0 serum_aminoacids serum_mcfa 0.626 0.00256 no no no up up no L-Methionine+blood L-2-Aminobutyric acid+blood 0.484210526 0 0 yes serum_aminoacids serum_aminoacids 0.626 0.000328 no no no up up no L-Methionine+blood L-Alanine+blood 0 0.718137255 0 yes serum_aminoacids serum_aminoacids 0.626 0.00138 no no no up up no L-Methionine+blood L-Arginine+blood 0.627067669 0.578431373 0 serum_aminoacids serum_aminoacids 0.626 0.316 no no no no no no L-Methionine+blood L-Asparagine+blood 0 0.737745098 0.626666667 serum_aminoacids serum_aminoacids 0.626 0.784 no no no no no no L-Methionine+blood L-Citrulline+blood 0.49924812 0 0.446153846 serum_aminoacids serum_aminoacids 0.626 0.534 no no no no no no L-Methionine+blood L-Glutamic acid+blood 0 0.549019608 0 yes serum_aminoacids serum_aminoacids 0.626 6.20E-05 no no no up up no L-Methionine+blood L-Glutamine+blood 0 0.512254902 0 serum_aminoacids serum_aminoacids 0.626 0.639 no no no no no no L-Methionine+blood L-Histidine+blood 0.566917293 0.539215686 0.472136752 serum_aminoacids serum_aminoacids 0.626 0.109 no no no no no no L-Methionine+blood L-Homocystine+blood 0.469172932 0 0 serum_aminoacids serum_aminoacids 0.626 0.197 no no no no no no L-Methionine+blood L-Isoleucine+blood 0 0.774509804 0.552820513 yes serum_aminoacids serum_aminoacids 0.626 5.47E-06 no no no up up no L-Methionine+blood L-Leucine+blood 0 0.727941176 0.409230769 yes serum_aminoacids serum_aminoacids 0.626 3.22E-05 no no no up up no L-Methionine+blood L-Lysine+blood 0.64962406 0.737745098 0 yes serum_aminoacids serum_aminoacids 0.626 0.0107 no no no no up no L-Methionine+blood L-Phenylalanine+stool 0 0 0.464661654 serum_aminoacids stool_cometabolism 0.626 0.398 no no no no no no L-Methionine+blood L-Tyrosine+stool 0 0 0.481203008 serum_aminoacids stool_cometabolism 0.626 0.44 no no no no no no L-Methionine+blood Lachnospira 0 0.543225117 0 butyrate-producing serum_aminoacids Genus 0.626 0.279 no no no no no no L-Methionine+blood Legionellosis -0.564912281 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Leishmaniasis -0.645614035 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Long-term depression 0 0 -0.460769231 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood mRNA surveillance pathway 0.515789474 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Non-alcoholic fatty liver disease 0.468421053 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Non-small cell lung cancer 0.464912281 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Oxytocin signaling pathway 0 0 -0.406923077 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Pancreatic cancer 0.5 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Pathways in cancer 0.607017544 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Phosphatidylinositol signaling system 0.528070175 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Phospholipase D signaling pathway 0.612280702 0 0 serum_aminoacids kegg 0.626 NA no no no no up up L-Methionine+blood Progesterone-mediated oocyte maturation 0 0 0.437692308 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Prolactin signaling pathway 0.610526316 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Renal cell carcinoma 0.478947368 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood RNA degradation 0.480701754 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Signaling pathways regulating pluripotency of stem cells 0.568421053 -0.532352941 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Sphingolipid signaling pathway 0.622807018 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Spinocerebellar ataxia 0 0 0.426153846 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood VEGF signaling pathway 0.61754386 0 0 serum_aminoacids kegg 0.626 NA no no no no no no L-Methionine+blood Vibrio cholerae infection 0 0 -0.404615385 serum_aminoacids kegg 0.626 NA no no no no no no L-Ornithine+blood 13-HODE+blood 0 0.534313725 0.421538462 serum_aminoacids serum_ARA 0.175 0.32 no no no no no no L-Ornithine+blood 14:0/18:0-PC+blood 0 0 -0.451623932 serum_aminoacids serum_phospholipids 0.175 0.00289 no no no up up no L-Ornithine+blood 14:0/18:2-PC+blood -0.634586466 -0.568627451 0 serum_aminoacids serum_phospholipids 0.175 0.102 no no no no up no L-Ornithine+blood 14:0/20:4-PC+blood -0.75037594 -0.556372549 -0.422222222 serum_aminoacids serum_phospholipids 0.175 0.486 no no no no no no L-Ornithine+blood 14:0+blood -0.454135338 0 0 yes serum_aminoacids serum_fattyacid 0.175 0.00572 no no no up no dn L-Ornithine+blood 16:0-LPE+blood 0 0.534313725 -0.580854701 serum_aminoacids serum_phospholipids 0.175 0.0711 no no no up up no L-Ornithine+blood 16:0/16:1-PC+blood 0 0 -0.495384615 serum_aminoacids serum_phospholipids 0.175 0.00283 no no no up up no L-Ornithine+blood 16:0/18:0-PC+blood 0 -0.598039216 0 serum_aminoacids serum_phospholipids 0.175 0.521 no no no no no no L-Ornithine+blood 16:0/18:0-PS+blood 0 0 -0.44957265 serum_aminoacids serum_phospholipids 0.175 0.377 no no no no no no L-Ornithine+blood 16:0/18:1-PE+blood 0 0 -0.40991453 serum_aminoacids serum_phospholipids 0.175 0.000107 no no no up up no L-Ornithine+blood 16:0/18:3-PC+blood 0 -0.580882353 -0.445470085 serum_aminoacids serum_phospholipids 0.175 0.00216 no no no no up up L-Ornithine+blood 16:0/20:5-PC+blood 0 -0.487745098 0 serum_aminoacids serum_phospholipids 0.175 0.628 no no no no no no L-Ornithine+blood 16:0/22:6-PE+blood 0 0 -0.50017094 serum_aminoacids serum_phospholipids 0.175 0.000934 no no no up up no L-Ornithine+blood 18:0-LPE+blood 0 0 -0.472136752 serum_aminoacids serum_phospholipids 0.175 0.491 no no no no no no L-Ornithine+blood 18:0/18:0-PS+blood 0 -0.517156863 0 serum_aminoacids serum_phospholipids 0.175 0.00617 no no no no up no L-Ornithine+blood 18:0/20:3-PC+blood -0.491729323 0 0 serum_aminoacids serum_phospholipids 0.175 0.0682 no no no no up no L-Ornithine+blood 18:0/22:6-PC+blood 0 0 0.458461538 serum_aminoacids serum_phospholipids 0.175 0.0775 no no no no no up L-Ornithine+blood 18:1-LPE+blood 0 0.68627451 0 serum_aminoacids serum_phospholipids 0.175 0.117 no no no no no no L-Ornithine+blood 18:1/18:0-PE+blood 0 0 -0.44957265 serum_aminoacids serum_phospholipids 0.175 1.39E-06 no no no up up no L-Ornithine+blood 18:1/18:1-PE+blood 0 0 -0.526837607 serum_aminoacids serum_phospholipids 0.175 1.03E-05 no no no up up no L-Ornithine+blood 18:1/18:2-PE+blood 0 0 -0.469401709 serum_aminoacids serum_phospholipids 0.175 0.000293 no no no up up no L-Ornithine+blood 18:1/18:2-PI+blood 0 0.600490196 0 serum_aminoacids serum_phospholipids 0.175 0.0164 no no no dn no up L-Ornithine+blood 18:3/16:0-PE+blood 0 0 -0.457094017 serum_aminoacids serum_phospholipids 0.175 0.00149 no no no up up no L-Ornithine+blood 18:3/18:2-PC+blood -0.469172932 0 0 serum_aminoacids serum_phospholipids 0.175 0.0394 no no no no no up L-Ornithine+blood 20:0/20:4-PE+blood 0 0 -0.469401709 serum_aminoacids serum_phospholipids 0.175 0.00128 no no no up up no L-Ornithine+blood 20:1/20:4-PC+blood 0 0 0.47965812 serum_aminoacids serum_phospholipids 0.175 0.0419 no no no no no up L-Ornithine+blood 20:1/20:4-PE+blood 0 0 -0.459145299 serum_aminoacids serum_phospholipids 0.175 0.0042 no no no up up no L-Ornithine+blood 20:2/18:0-PC+blood -0.559398496 0 0 serum_aminoacids serum_phospholipids 0.175 0.0427 no no no no up no L-Ornithine+blood 20:2/18:1-PE+blood 0 0 -0.621880342 serum_aminoacids serum_phospholipids 0.175 0.00208 no no no up up no L-Ornithine+blood 20:3-LPE+blood 0 0 -0.407179487 serum_aminoacids serum_phospholipids 0.175 0.084 no no no no up no L-Ornithine+blood 20:4/18:0-PE+blood 0 0 -0.436581197 serum_aminoacids serum_phospholipids 0.175 0.000755 no no no up up no L-Ornithine+blood 22:6-LPC+blood 0 0 0.419487179 serum_aminoacids serum_phospholipids 0.175 0.127 no no no no no up L-Ornithine+blood 3-(3-Hydroxyphenyl)propanoic acid+stool -0.67032967 0 0 serum_aminoacids stool_cometabolism 0.175 0.33 no no no no no no L-Ornithine+blood 8-HETE+blood 0 0.5 0 serum_aminoacids serum_ARA 0.175 0.741 no no no no no no L-Ornithine+blood 9-HODE+blood -0.484210526 0 0 serum_aminoacids serum_ARA 0.175 0.297 no no no no no no L-Ornithine+blood Adherens junction 0 -0.520588235 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Adipocytokine signaling pathway 0.557894737 0.517647059 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Allograft rejection 0 0 -0.528461538 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Alzheimer disease 0 0 -0.467692308 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Amyotrophic lateral sclerosis 0 0 -0.412307692 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Antigen processing and presentation 0 0 -0.435384615 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Arrhythmogenic right ventricular cardiomyopathy 0 -0.582352941 0 serum_aminoacids kegg 0.175 NA no no no no up up L-Ornithine+blood Asthma 0 -0.635294118 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Autoimmune thyroid disease 0 0 -0.528461538 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Bacterial invasion of epithelial cells 0 -0.505882353 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Betaine+blood 0 0 0.474871795 serum_aminoacids serum_choline 0.175 0.857 no no no no no no L-Ornithine+blood Bifidobacterium -0.594208391 0 0 acetate-producing serum_aminoacids Genus 0.175 0.105 no no no no dn no L-Ornithine+blood Blautia 0 0 -0.461409233 acetate-producing serum_aminoacids Genus 0.175 1.36E-05 no no no up dn dn L-Ornithine+blood butyric acid C4+blood 0 0.593137255 0 serum_aminoacids serum_scfa 0.175 0.407 no no no no no no L-Ornithine+blood CA+stool 0 0 -0.544360902 serum_aminoacids stool_bileacids 0.175 0.827 no no no no no no L-Ornithine+blood Carbon metabolism 0 -0.611764706 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Cardiac muscle contraction 0 0 -0.436153846 serum_aminoacids kegg 0.175 NA no no no no no up L-Ornithine+blood CDCA+stool 0 0 -0.493233083 serum_aminoacids stool_bileacids 0.175 0.663 no no no no no no L-Ornithine+blood Cell adhesion molecules 0 0 -0.5 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Cell cycle -0.563157895 0 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Cellular senescence 0 0 -0.429230769 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Central carbon metabolism in cancer -0.485964912 0 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Cystine+blood 0.609022556 0 0 yes serum_aminoacids serum_aminoacids 0.175 0.00028 no no no up up no L-Ornithine+blood Cytosolic DNA-sensing pathway 0 0.535294118 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood d18:0-18:3-SM+blood 0 0 -0.417435897 serum_aminoacids serum_phospholipids 0.175 0.0879 no no no no dn no L-Ornithine+blood d18:1-14:0-SM+blood -0.622556391 -0.642156863 -0.44957265 serum_aminoacids serum_phospholipids 0.175 0.94 no no no no no no L-Ornithine+blood d18:1-14:1-SM+blood -0.676691729 -0.509803922 -0.543931624 serum_aminoacids serum_phospholipids 0.175 0.0952 no no no no dn no L-Ornithine+blood d18:1-16:1-SM+blood 0 0 -0.415384615 serum_aminoacids serum_phospholipids 0.175 0.2 no no no no no no L-Ornithine+blood d18:1-18:1-SM+blood 0 0 -0.488547009 serum_aminoacids serum_phospholipids 0.175 0.916 no no no no no no L-Ornithine+blood d18:1-20:0-SM+blood -0.529323308 0 0 serum_aminoacids serum_phospholipids 0.175 0.933 no no no no no no L-Ornithine+blood DHA+blood -0.494736842 0 0 serum_aminoacids serum_ARA 0.175 0.872 no no no no no no L-Ornithine+blood Diabetic cardiomyopathy 0 0 -0.411538462 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood DL-methionine sulfoxide+blood 0.706766917 0.490196078 0 serum_aminoacids serum_aminoacids 0.175 0.302 no no no no no no L-Ornithine+blood DPA+blood 0 0 0.420854701 serum_aminoacids serum_ARA 0.175 0.519 no no no no no no L-Ornithine+blood Epstein-Barr virus infection 0 0 -0.453076923 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Focal adhesion 0 -0.55 0 serum_aminoacids kegg 0.175 NA no no no no up up L-Ornithine+blood FoxO signaling pathway 0 0 0.424615385 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Glycolysis / Gluconeogenesis 0 -0.535294118 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Graft-versus-host disease 0 0 -0.513076923 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood HDCA+blood 0 0 0.47447742 serum_aminoacids serum_bileacids 0.175 0.483 no no no no no no L-Ornithine+blood Hematopoietic cell lineage 0 -0.608823529 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Hepatitis C 0 0.502941176 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Hepatocellular carcinoma 0 -0.517647059 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood heptanoic acid C7+blood 0 0 0.478290598 serum_aminoacids serum_mcfa 0.175 8.27E-11 no no no dn dn no L-Ornithine+blood Herpes simplex virus 1 infection 0 0 -0.431538462 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Human cytomegalovirus infection 0 0 -0.553846154 serum_aminoacids kegg 0.175 NA no no no no no dn L-Ornithine+blood Human immunodeficiency virus 1 infection 0 0 -0.485384615 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Human T-cell leukemia virus 1 infection 0 0 -0.521538462 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Huntington disease 0 0 -0.456153846 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Hypertrophic cardiomyopathy 0 -0.567647059 0 serum_aminoacids kegg 0.175 NA no no no no up up L-Ornithine+blood Inflammatory bowel disease 0 -0.708823529 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Intestinal immune network for IgA production 0 -0.635294118 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood iso-LCA+blood 0 0 0.666135246 serum_aminoacids serum_bileacids 0.175 0.507 no no no no no no L-Ornithine+blood L-Alanine+blood 0.772932331 0 0 yes serum_aminoacids serum_aminoacids 0.175 0.00138 no no no up up no L-Ornithine+blood L-Asparagine+blood 0.643609023 0 0 serum_aminoacids serum_aminoacids 0.175 0.784 no no no no no no L-Ornithine+blood L-Aspartic acid+blood 0 0 0.52 yes serum_aminoacids serum_aminoacids 0.175 0.0226 no no no up up no L-Ornithine+blood L-Citrulline+blood 0.458646617 0.620098039 0.427008547 serum_aminoacids serum_aminoacids 0.175 0.534 no no no no no no L-Ornithine+blood L-Glutamic acid+blood 0.496240602 0 0.452991453 yes serum_aminoacids serum_aminoacids 0.175 6.20E-05 no no no up up no L-Ornithine+blood L-Glutamine+blood 0.616541353 0 0 serum_aminoacids serum_aminoacids 0.175 0.639 no no no no no no L-Ornithine+blood L-Histidine+blood 0 0 0.545299145 serum_aminoacids serum_aminoacids 0.175 0.109 no no no no no no L-Ornithine+blood L-Isoleucine+blood 0 0 0.435897436 yes serum_aminoacids serum_aminoacids 0.175 5.47E-06 no no no up up no L-Ornithine+blood L-Lysine+blood 0.619548872 0 0.470769231 yes serum_aminoacids serum_aminoacids 0.175 0.0107 no no no no up no L-Ornithine+blood L-Phenylalanine+stool 0 0 0.496240602 serum_aminoacids stool_cometabolism 0.175 0.398 no no no no no no L-Ornithine+blood L-Tryptophan+stool 0 0 0.458646617 serum_aminoacids stool_cometabolism 0.175 0.557 no no no no no no L-Ornithine+blood L-Tyrosine+stool 0 0 0.554887218 serum_aminoacids stool_cometabolism 0.175 0.44 no no no no no no L-Ornithine+blood Leishmaniasis -0.49122807 0 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood MicroRNAs in cancer 0 0.517647059 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Mineral absorption 0.468421053 0 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Non-alcoholic fatty liver disease 0 0 -0.492307692 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood nutriCA+stool 0 -0.669752957 0 serum_aminoacids stool_bileacids 0.175 0.481 no no no no no no L-Ornithine+blood Oxidative phosphorylation 0 0 -0.431538462 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Platelet activation 0 -0.561764706 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Primary immunodeficiency -0.512280702 0 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Prion disease 0 0 -0.462307692 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Progesterone-mediated oocyte maturation -0.492982456 0 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Retrograde endocannabinoid signaling 0 0 -0.441538462 serum_aminoacids kegg 0.175 NA no no no no no up L-Ornithine+blood Ribosome biogenesis in eukaryotes -0.457894737 0 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood RNA transport -0.496491228 0 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Spliceosome -0.526315789 0 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Thermogenesis 0 0 -0.427692308 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Transcriptional misregulation in cancer 0 0.535294118 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Type I diabetes mellitus 0 0 -0.526153846 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood UDCA+stool 0 0 -0.452631579 serum_aminoacids stool_bileacids 0.175 0.266 no no no no no no L-Ornithine+blood Vibrio cholerae infection 0 -0.5 0 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Viral carcinogenesis 0 0 -0.425384615 serum_aminoacids kegg 0.175 NA no no no no no no L-Ornithine+blood Viral myocarditis 0 0 -0.527692308 serum_aminoacids kegg 0.175 NA no no no no no no L-Phenylalanine+blood 12-HEPE+blood 0.483785237 -0.612531804 0 yes serum_aminoacids serum_ARA 0.0103 0.312 up up no no no no L-Phenylalanine+blood 14:0/18:0-PC+blood -0.520300752 0 0 yes serum_aminoacids serum_phospholipids 0.0103 0.00289 up up no up up no L-Phenylalanine+blood 14:0/20:4-PC+blood 0 -0.546568627 0 yes serum_aminoacids serum_phospholipids 0.0103 0.486 up up no no no no L-Phenylalanine+blood 15-HETE+blood 0 0 -0.413155187 yes serum_aminoacids serum_ARA 0.0103 0.819 up up no no no no L-Phenylalanine+blood 16:0/18:2-PC+blood 0.461654135 0 0 yes serum_aminoacids serum_phospholipids 0.0103 3.24E-06 up up no no up up L-Phenylalanine+blood 16:0/20:5-PC+blood 0 -0.664215686 0 yes serum_aminoacids serum_phospholipids 0.0103 0.628 up up no no no no L-Phenylalanine+blood 16:0/22:0-PE+blood 0.446616541 0 0 yes serum_aminoacids serum_phospholipids 0.0103 0.00839 up up no dn no up L-Phenylalanine+blood 16:0/22:6-PC+blood 0.515789474 0 0 yes serum_aminoacids serum_phospholipids 0.0103 4.53E-05 up up no no up up L-Phenylalanine+blood 18:0/22:6-PC+blood 0.535338346 0 0.443418803 yes serum_aminoacids serum_phospholipids 0.0103 0.0775 up up no no no up L-Phenylalanine+blood 18:1/16:0-PC+blood 0.44962406 0 0 yes serum_aminoacids serum_phospholipids 0.0103 2.43E-05 up up no no up up L-Phenylalanine+blood 18:1/16:0-PE+blood -0.50075188 0 0 yes serum_aminoacids serum_phospholipids 0.0103 0.000182 up up no up up no L-Phenylalanine+blood 18:2-LPA+blood 0 0.546568627 0 yes serum_aminoacids serum_phospholipids 0.0103 0.00684 up up no dn no up L-Phenylalanine+blood 18:2/20:4-PC+blood 0 -0.546568627 0 yes serum_aminoacids serum_phospholipids 0.0103 0.0145 up up no no no up L-Phenylalanine+blood 18:3/16:0-PE+blood -0.569924812 0 0 yes serum_aminoacids serum_phospholipids 0.0103 0.00149 up up no up up no L-Phenylalanine+blood 18:3/18:2-PC+blood 0 0 -0.414017094 yes serum_aminoacids serum_phospholipids 0.0103 0.0394 up up no no no up L-Phenylalanine+blood 18:3n6+blood -0.65112782 0 0 yes serum_aminoacids serum_fattyacid 0.0103 0.0463 up up no up no dn L-Phenylalanine+blood 20:0+blood 0 -0.524509804 0 yes yes serum_aminoacids serum_fattyacid 0.0103 0.000278 up up no dn no up L-Phenylalanine+blood 20:1/20:4-PC+blood 0.571428571 0 0.413333333 yes serum_aminoacids serum_phospholipids 0.0103 0.0419 up up no no no up L-Phenylalanine+blood 20:2/18:1-PE+blood -0.503759398 0 0 yes serum_aminoacids serum_phospholipids 0.0103 0.00208 up up no up up no L-Phenylalanine+blood 20:3-LPE+blood -0.518796992 0 0 yes serum_aminoacids serum_phospholipids 0.0103 0.084 up up no no up no L-Phenylalanine+blood 20:5/18:0-PC+blood 0.535338346 0 0 yes serum_aminoacids serum_phospholipids 0.0103 3.97E-06 up up no no up up L-Phenylalanine+blood 20:5n3+blood 0 -0.629901961 0 yes serum_aminoacids serum_fattyacid 0.0103 0.988 up up no no no no L-Phenylalanine+blood 22:0/16:0-PE+blood 0.457142857 0 0 yes serum_aminoacids serum_phospholipids 0.0103 0.091 up up no no no up L-Phenylalanine+blood 22:2-LPA+blood 0 0.575980392 0 yes serum_aminoacids serum_phospholipids 0.0103 0.0443 up up no dn no no L-Phenylalanine+blood 22:6-LPC+blood 0 0 0.532307692 yes serum_aminoacids serum_phospholipids 0.0103 0.127 up up no no no up L-Phenylalanine+blood Acute myeloid leukemia 0 0 0.47 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Adrenergic signaling in cardiomyocytes 0.471929825 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no up L-Phenylalanine+blood AGE-RAGE signaling pathway in diabetic complications 0.478947368 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Alistipes 0 -0.505211622 0 yes serum_aminoacids Genus 0.0103 0.0114 up up no no up no L-Phenylalanine+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.460769231 yes serum_aminoacids kegg 0.0103 NA up up no no up up L-Phenylalanine+blood Asthma 0 0 -0.540769231 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Bifidobacterium 0 0.603310966 0 yes acetate-producing serum_aminoacids Genus 0.0103 0.105 up up no no dn no L-Phenylalanine+blood Biosynthesis of amino acids -0.526315789 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Blautia 0 0.715686275 0 yes acetate-producing serum_aminoacids Genus 0.0103 1.36E-05 up up no up dn dn L-Phenylalanine+blood Breast cancer 0.557894737 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Butyricimonas 0.455955496 0 0 yes butyrate-producing serum_aminoacids Genus 0.0103 0.17 up up no no no no L-Phenylalanine+blood cAMP signaling pathway 0.50877193 0 0 yes yes serum_aminoacids kegg 0.0103 NA up up no no up up L-Phenylalanine+blood Carbon metabolism -0.605263158 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Cell adhesion molecules 0 0 -0.407692308 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Chemical carcinogenesis - receptor activation 0.496491228 -0.726470588 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Choline metabolism in cancer 0.557894737 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Choline+blood 0.535338346 0 0.500854701 yes serum_aminoacids serum_choline 0.0103 0.0395 up up no no up no L-Phenylalanine+blood Cholinergic synapse 0 -0.617647059 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Clostridium 0 0.58614358 0 yes serum_aminoacids Genus 0.0103 0.925 up up no no no no L-Phenylalanine+blood Colorectal cancer 0.531578947 -0.558823529 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Creatinine+blood 0.563909774 0.647058824 0 yes serum_aminoacids serum_choline 0.0103 0.437 up up no no no no L-Phenylalanine+blood Cushing syndrome 0 -0.517647059 0 yes serum_aminoacids kegg 0.0103 NA up up no no no up L-Phenylalanine+blood Cysteine+blood 0 0 0.459145299 yes yes serum_aminoacids serum_aminoacids 0.0103 1.81E-07 up up no dn up up L-Phenylalanine+blood Cystine+blood 0 0.713235294 0 yes yes serum_aminoacids serum_aminoacids 0.0103 0.00028 up up no up up no L-Phenylalanine+blood d18:0-18:3-SM+blood 0 0 -0.408547009 yes serum_aminoacids serum_phospholipids 0.0103 0.0879 up up no no dn no L-Phenylalanine+blood d18:1-22:1-SM+blood -0.464661654 0 0 yes serum_aminoacids serum_phospholipids 0.0103 0.222 up up no no no no L-Phenylalanine+blood decanoic acid C10+blood 0 0.495098039 0 yes serum_aminoacids serum_mcfa 0.0103 6.64E-11 up up no dn dn no L-Phenylalanine+blood Dilated cardiomyopathy 0 0 -0.443846154 yes serum_aminoacids kegg 0.0103 NA up up no no up up L-Phenylalanine+blood DL-methionine sulfoxide+blood 0 0.683823529 0.506324786 yes serum_aminoacids serum_aminoacids 0.0103 0.302 up up no no no no L-Phenylalanine+blood DMG+blood 0 0.696078431 0.551452991 yes serum_aminoacids serum_choline 0.0103 0.909 up up no no no no L-Phenylalanine+blood Dorea 0 0.593137255 0 yes serum_aminoacids Genus 0.0103 0.00362 up up no up no dn L-Phenylalanine+blood Endocrine resistance 0.496491228 -0.558823529 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood ErbB signaling pathway 0.624561404 -0.526470588 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Estrogen signaling pathway 0 0 -0.406153846 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Ethanolamine+blood 0 0 0.621196581 yes serum_aminoacids serum_aminoacids 0.0103 0.122 up up no up no no L-Phenylalanine+blood Fc epsilon RI signaling pathway 0.605263158 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Focal adhesion 0 0 -0.565384615 yes serum_aminoacids kegg 0.0103 NA up up no no up up L-Phenylalanine+blood FoxO signaling pathway 0.507017544 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Gastric cancer 0.596491228 -0.541176471 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood GCDCA+stool 0 0.654545455 -0.491729323 yes yes serum_aminoacids stool_bileacids 0.0103 0.0471 up up no no dn no L-Phenylalanine+blood GDCA+stool 0 0.715263815 -0.490964412 yes serum_aminoacids stool_bileacids 0.0103 0.656 up up no no no no L-Phenylalanine+blood Gemmiger 0 0 0.429795151 yes butyrate-producing serum_aminoacids Genus 0.0103 0.595 up up no no no no L-Phenylalanine+blood Glioma 0.480701754 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Glutathione metabolism -0.480701754 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Glycolysis / Gluconeogenesis -0.585964912 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood "Growth hormone synthesis, secretion and action" 0.531578947 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Hematopoietic cell lineage 0 0 -0.476153846 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Hepatitis B 0.501754386 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood heptanoic acid C7+blood 0 0 0.442735043 yes serum_aminoacids serum_mcfa 0.0103 8.27E-11 up up no dn dn no L-Phenylalanine+blood Hippo signaling pathway 0 0 -0.534615385 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Hypertrophic cardiomyopathy 0 0 -0.440769231 yes serum_aminoacids kegg 0.0103 NA up up no no up up L-Phenylalanine+blood Inflammatory bowel disease 0 0 -0.476923077 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Influenza A 0 0.570588235 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Intestinal immune network for IgA production 0 0 -0.620769231 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood iso-DCA+blood 0 0 0.528205128 yes serum_aminoacids serum_bileacids 0.0103 0.38 up up no no no no L-Phenylalanine+blood iso-heptanoic acid C7+blood -0.461654135 0 0 yes serum_aminoacids serum_mcfa 0.0103 0.00256 up up no up up no L-Phenylalanine+blood isovaleric acid iso-C5+blood 0 -0.485294118 0 yes serum_aminoacids serum_scfa 0.0103 0.117 up up no no no no L-Phenylalanine+blood L-Arginine+blood 0.521804511 0.583333333 0.432478632 yes serum_aminoacids serum_aminoacids 0.0103 0.316 up up no no no no L-Phenylalanine+blood L-Glutamic acid+blood 0 0.713235294 0.419487179 yes yes serum_aminoacids serum_aminoacids 0.0103 6.20E-05 up up no up up no L-Phenylalanine+blood L-Glutamine+blood 0 0.534313725 0 yes serum_aminoacids serum_aminoacids 0.0103 0.639 up up no no no no L-Phenylalanine+blood L-Histidine+blood 0.6 0 0.552820513 yes serum_aminoacids serum_aminoacids 0.0103 0.109 up up no no no no L-Phenylalanine+blood L-Isoleucine+blood 0.551879699 0.779411765 0.832478632 yes yes serum_aminoacids serum_aminoacids 0.0103 5.47E-06 up up no up up no L-Phenylalanine+blood L-Leucine+blood 0 0 0.738803419 yes yes serum_aminoacids serum_aminoacids 0.0103 3.22E-05 up up no up up no L-Phenylalanine+blood L-Lysine+blood 0.628571429 0.713235294 0.625299145 yes yes serum_aminoacids serum_aminoacids 0.0103 0.0107 up up no no up no L-Phenylalanine+blood L-Methionine+blood 0.836090226 0.720588235 0.423589744 yes serum_aminoacids serum_aminoacids 0.0103 0.626 up up no no no no L-Phenylalanine+blood L-Ornithine+blood 0 0 0.420854701 yes serum_aminoacids serum_aminoacids 0.0103 0.175 up up no no no no L-Phenylalanine+blood Leishmaniasis -0.496491228 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Leukocyte transendothelial migration 0 0 -0.405384615 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood MAPK signaling pathway 0 -0.541176471 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood mRNA surveillance pathway 0.580701754 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Non-small cell lung cancer 0.601754386 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Oscillospira 0 0 0.408547009 yes LPS-producing serum_aminoacids Genus 0.0103 0.62 up up no no no no L-Phenylalanine+blood Pancreatic cancer 0.485964912 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Parabacteroides 0 -0.522058824 0.455804418 yes serum_aminoacids Genus 0.0103 4.19E-05 up up no no up up L-Phenylalanine+blood Pathways in cancer 0.652631579 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Phosphatidylinositol signaling system 0.456140351 -0.526470588 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Phospholipase D signaling pathway 0.584210526 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no up up L-Phenylalanine+blood Prolactin signaling pathway 0.478947368 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Proteasome 0 0 0.462307692 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Regulation of actin cytoskeleton -0.464912281 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Rheumatoid arthritis 0 0 -0.518461538 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood RNA degradation 0.466666667 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Roseburia 0 0.488044236 0 yes butyrate-producing serum_aminoacids Genus 0.0103 0.495 up up no no no no L-Phenylalanine+blood Salmonella infection 0 0.5 -0.457692308 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Signaling pathways regulating pluripotency of stem cells 0.610526316 -0.602941176 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Sphingolipid signaling pathway 0.50877193 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Thyroid hormone signaling pathway 0 0 -0.413846154 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Toxoplasmosis 0 0 -0.413846154 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood VEGF signaling pathway 0.573684211 0 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+blood Yersinia infection 0 0.55 0 yes serum_aminoacids kegg 0.0103 NA up up no no no no L-Phenylalanine+stool 5-Hydroxytryptamine+stool 0 0 0.486166008 stool_cometabolism stool_cometabolism 0.398 0.00862 no no no dn dn no L-Phenylalanine+stool ACA+stool 0 -0.591312396 0 stool_cometabolism stool_bileacids 0.398 0.417 no no no no no no L-Phenylalanine+stool Allograft rejection 0 0 -0.566346697 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Antigen processing and presentation 0 0 -0.46809712 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Apelin signaling pathway -0.486068111 0 0 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Autoimmune thyroid disease 0 0 -0.566346697 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Butyric acid+stool -0.492260062 0 0 yes stool_cometabolism stool_scfa 0.398 0.102 no no no dn no no L-Phenylalanine+stool Butyricicoccus 0 0 -0.532132374 butyrate-producing stool_cometabolism Genus 0.398 0.852 no no no no no no L-Phenylalanine+stool CA+stool 0 0 -0.56027668 stool_cometabolism stool_bileacids 0.398 0.827 no no no no no no L-Phenylalanine+stool CDCA+stool 0 0 -0.589920949 stool_cometabolism stool_bileacids 0.398 0.663 no no no no no no L-Phenylalanine+stool Cell adhesion molecules 0 0 -0.558441558 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Cellular senescence 0 0 -0.566346697 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Clostridium 0.486992066 0 0 stool_cometabolism Genus 0.398 0.925 no no no no no no L-Phenylalanine+stool DCA+stool -0.496388029 0 0 stool_cometabolism stool_bileacids 0.398 0.195 no no no no no no L-Phenylalanine+stool Endocytosis 0 0 -0.53811406 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Epstein-Barr virus infection 0 0 -0.488424619 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool GCDCA+stool 0 -0.657342657 0 yes stool_cometabolism stool_bileacids 0.398 0.0471 no no no no dn no L-Phenylalanine+stool Gemmiger -0.649458011 0 0 butyrate-producing stool_cometabolism Genus 0.398 0.595 no no no no no no L-Phenylalanine+stool Graft-versus-host disease 0 0 -0.56295878 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Herpes simplex virus 1 infection 0 0 -0.428571429 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Human cytomegalovirus infection 0 0 -0.473743648 stool_cometabolism kegg 0.398 NA no no no no no dn L-Phenylalanine+stool Human immunodeficiency virus 1 infection 0 0 -0.465838509 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Human papillomavirus infection 0 0 -0.480519481 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Human T-cell leukemia virus 1 infection 0 0 -0.459062676 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Indole-3-Acetic acid+stool 0.529411765 0 0.726284585 stool_cometabolism stool_cometabolism 0.398 0.304 no no no no no no L-Phenylalanine+stool Isobutyric acid+stool 0 0.664335664 0.543478261 stool_cometabolism stool_scfa 0.398 0.408 no no no no no no L-Phenylalanine+stool Isovaleric acid+stool 0 0.706293706 0.520750988 stool_cometabolism stool_scfa 0.398 0.343 no no no no no no L-Phenylalanine+stool Kynurenic acid+stool 0 0.608391608 0 stool_cometabolism stool_cometabolism 0.398 0.037 no no no dn dn no L-Phenylalanine+stool Legionellosis -0.51496388 0 0 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Methanobrevibacter 0 0 0.444554224 stool_cometabolism Genus 0.398 0.629 no no no no no no L-Phenylalanine+stool mTOR signaling pathway -0.498452012 0 0 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Natural killer cell mediated cytotoxicity 0 0 -0.496329757 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Neutrophil extracellular trap formation 0.475748194 0 0 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Phagosome 0 0 -0.464709204 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Purine metabolism -0.572755418 0 0 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool RNA transport -0.492260062 0 0 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Succinivibrio 0 0 -0.456470037 stool_cometabolism Genus 0.398 0.138 no no no no no no L-Phenylalanine+stool Tuberculosis 0.496388029 0 0 stool_cometabolism kegg 0.398 NA no no no no no dn L-Phenylalanine+stool Type I diabetes mellitus 0 0 -0.569734613 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Viral carcinogenesis 0 0 -0.5256917 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool Viral myocarditis 0 0 -0.561829475 stool_cometabolism kegg 0.398 NA no no no no no no L-Phenylalanine+stool ¦Ø-MCA+stool 0 -0.701819726 0 stool_cometabolism stool_bileacids 0.398 0.919 no no no no no no L-Phenylalanine+urine 16:0/16:0-PC+blood 0.882352941 0 0 urine_cometabolism serum_phospholipids 0.0908 0.00079 no up no no up up L-Phenylalanine+urine 16:0/18:0-PC+blood 0.556372549 0 0 urine_cometabolism serum_phospholipids 0.0908 0.521 no up no no no no L-Phenylalanine+urine 16:0/18:1-PC+blood 0.536764706 0 0 urine_cometabolism serum_phospholipids 0.0908 6.15E-07 no up no up up up L-Phenylalanine+urine 16:0/18:2-PC+blood 0.593137255 0 0 urine_cometabolism serum_phospholipids 0.0908 3.24E-06 no up no no up up L-Phenylalanine+urine 16:0/20:3-PC+blood 0.656862745 0 0 urine_cometabolism serum_phospholipids 0.0908 5.43E-06 no up no no up up L-Phenylalanine+urine 16:0/22:6-PC+blood 0.607843137 0 0 urine_cometabolism serum_phospholipids 0.0908 4.53E-05 no up no no up up L-Phenylalanine+urine 16:1/16:0-PC+blood 0.602941176 0 0 urine_cometabolism serum_phospholipids 0.0908 0.0215 no up no no up up L-Phenylalanine+urine 16:1/16:1-PC+blood 0.575980392 0 0 urine_cometabolism serum_phospholipids 0.0908 0.0177 no up no no no up L-Phenylalanine+urine 18:0/16:0-PC+blood 0.56127451 0 0 urine_cometabolism serum_phospholipids 0.0908 9.64E-07 no up no up up up L-Phenylalanine+urine 18:0/18:1-PE+blood -0.485294118 0 0 urine_cometabolism serum_phospholipids 0.0908 0.00716 no up no up up no L-Phenylalanine+urine 18:0/18:2-PC+blood 0.605392157 0 0 urine_cometabolism serum_phospholipids 0.0908 1.74E-06 no up no no up up L-Phenylalanine+urine 18:0/18:2-PI+blood 0 0 0.548051948 urine_cometabolism serum_phospholipids 0.0908 0.179 no up no no no no L-Phenylalanine+urine 18:0/20:4-PI+blood 0 0 0.566233766 urine_cometabolism serum_phospholipids 0.0908 0.167 no up no no no no L-Phenylalanine+urine 18:0/22:6-PA+blood 0.553921569 0 0 urine_cometabolism serum_phospholipids 0.0908 0.22 no up no no no no L-Phenylalanine+urine 18:0/22:6-PC+blood 0.482843137 0 0 urine_cometabolism serum_phospholipids 0.0908 0.0775 no up no no no up L-Phenylalanine+urine 18:1/16:0-PC+blood 0.580882353 0 0 urine_cometabolism serum_phospholipids 0.0908 2.43E-05 no up no no up up L-Phenylalanine+urine 18:1/18:0-PC+blood 0.669117647 0 0 urine_cometabolism serum_phospholipids 0.0908 1.83E-06 no up no no up up L-Phenylalanine+urine 18:1/18:1-PC+blood 0.593137255 0 0 urine_cometabolism serum_phospholipids 0.0908 1.34E-05 no up no no up up L-Phenylalanine+urine 18:2/16:0-PC+blood 0.580882353 0 0 urine_cometabolism serum_phospholipids 0.0908 8.67E-05 no up no no up up L-Phenylalanine+urine 2-hydroxyhippuric acid+urine -0.696240602 0 -0.504273504 urine_cometabolism urine_cometabolism 0.0908 0.215 no up no no no no L-Phenylalanine+urine 2-hydroxyphenylacetic acid+urine 0 -0.496491228 -0.453675214 urine_cometabolism urine_cometabolism 0.0908 0.763 no up no no no no L-Phenylalanine+urine 20:1-LPA+blood 0 -0.620879121 0 urine_cometabolism serum_phospholipids 0.0908 0.0187 no up no dn dn no L-Phenylalanine+urine 20:3/18:0-PC+blood 0.62745098 0 0 urine_cometabolism serum_phospholipids 0.0908 0.296 no up no no no no L-Phenylalanine+urine 20:5/18:0-PC+blood 0.595588235 0 0 urine_cometabolism serum_phospholipids 0.0908 3.97E-06 no up no no up up L-Phenylalanine+urine "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.64034188 urine_cometabolism urine_cometabolism 0.0908 0.0125 no up no up up no L-Phenylalanine+urine 3-Hydroxy-L-kynurenine+urine 0.732330827 0.678947368 0.72034188 urine_cometabolism urine_cometabolism 0.0908 0.401 no up no no no no L-Phenylalanine+urine 3-Hydroxytyramine hydrochloride+urine 0 0 0.50017094 urine_cometabolism urine_cometabolism 0.0908 0.288 no up no no no no L-Phenylalanine+urine 5-Hydroxytryptamine+urine 0 0.477192982 0 urine_cometabolism urine_cometabolism 0.0908 0.171 no up no no no no L-Phenylalanine+urine Alcoholism 0 -0.61754386 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Amoebiasis 0 -0.566666667 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Anaerostipes 0.572834267 0 0 butyrate-producing urine_cometabolism Genus 0.0908 0.568 no up no no no no L-Phenylalanine+urine Apelin signaling pathway 0 0.484210526 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Arrhythmogenic right ventricular cardiomyopathy -0.475438596 0 0 urine_cometabolism kegg 0.0908 NA no up no no up up L-Phenylalanine+urine Axon guidance 0.456140351 0 0 urine_cometabolism kegg 0.0908 NA no up no no up up L-Phenylalanine+urine Biosynthesis of amino acids 0 -0.456140351 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Biosynthesis of cofactors -0.510526316 0 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Bladder cancer 0 -0.487719298 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine CDCA+blood 0 0.769230769 0 urine_cometabolism serum_bileacids 0.0908 0.506 no up no no no no L-Phenylalanine+urine Colorectal cancer 0 0.514035088 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Coronavirus disease - COVID-19 0 0 0.414615385 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Cysteine+blood 0 -0.642857143 0 yes urine_cometabolism serum_aminoacids 0.0908 1.81E-07 no up no dn up up L-Phenylalanine+urine Diabetic cardiomyopathy 0 0.456140351 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine DL-Indole-3-lactic acid+urine 0 0 0.424957265 urine_cometabolism urine_cometabolism 0.0908 0.00552 no up no up up no L-Phenylalanine+urine DPA+blood 0 -0.56043956 0 urine_cometabolism serum_ARA 0.0908 0.519 no up no no no no L-Phenylalanine+urine EGFR tyrosine kinase inhibitor resistance 0 0.533333333 0.413846154 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine EPA+blood 0.524509804 0 0 urine_cometabolism serum_ARA 0.0908 0.212 no up no no no no L-Phenylalanine+urine Fc epsilon RI signaling pathway 0 -0.5 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Fc gamma R-mediated phagocytosis 0 -0.466666667 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine GABAergic synapse 0 -0.536842105 0 urine_cometabolism kegg 0.0908 NA no up no no up up L-Phenylalanine+urine GCA+blood -0.75 0 0 yes urine_cometabolism serum_bileacids 0.0908 0.16 no up no no no no L-Phenylalanine+urine GCDCA+blood -0.607843137 0 0 urine_cometabolism serum_bileacids 0.0908 0.31 no up no no no no L-Phenylalanine+urine GDCA+stool 0 0 -0.598760329 urine_cometabolism stool_bileacids 0.0908 0.656 no up no no no no L-Phenylalanine+urine Glutamatergic synapse 0 -0.573684211 0 urine_cometabolism kegg 0.0908 NA no up no no up up L-Phenylalanine+urine Glycine+blood 0 -0.818681319 0 urine_cometabolism serum_aminoacids 0.0908 0.00408 no up no dn no up L-Phenylalanine+urine GUDCA+blood -0.573529412 0 0 urine_cometabolism serum_bileacids 0.0908 0.0766 no up no no no dn L-Phenylalanine+urine HCA+blood 0 0.570849278 0 urine_cometabolism serum_bileacids 0.0908 0.544 no up no no no no L-Phenylalanine+urine Hepatitis C 0.535087719 0 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Hepatocellular carcinoma -0.471929825 0 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine HIF-1 signaling pathway 0 0.49122807 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Hypertrophic cardiomyopathy -0.466666667 0 0 urine_cometabolism kegg 0.0908 NA no up no no up up L-Phenylalanine+urine IL-17 signaling pathway 0 -0.464912281 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Indole-3-Acetic acid+urine 0 -0.552631579 0 urine_cometabolism urine_cometabolism 0.0908 0.657 no up no no no no L-Phenylalanine+urine Insulin signaling pathway 0 0.503508772 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine iso-DCA+blood 0.553921569 0 0 urine_cometabolism serum_bileacids 0.0908 0.38 no up no no no no L-Phenylalanine+urine L-Alanine+blood -0.5 0 0 yes urine_cometabolism serum_aminoacids 0.0908 0.00138 no up no up up no L-Phenylalanine+urine Long-term potentiation 0.487719298 0 0 urine_cometabolism kegg 0.0908 NA no up no no no up L-Phenylalanine+urine mRNA surveillance pathway 0 0.466666667 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine mTOR signaling pathway 0 0.563157895 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine MUFA%+blood 0 -0.725274725 0 urine_cometabolism serum_fattyacid 0.0908 0.00142 no up no up no dn L-Phenylalanine+urine Neurotrophin signaling pathway 0.521052632 0 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Neutrophil extracellular trap formation 0 -0.484210526 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Oxytocin signaling pathway -0.478947368 0 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Paraprevotella 0 0.494378563 0 urine_cometabolism Genus 0.0908 0.118 no up no no no no L-Phenylalanine+urine Phospholipase D signaling pathway 0 -0.526315789 0 urine_cometabolism kegg 0.0908 NA no up no no up up L-Phenylalanine+urine PI3K-Akt signaling pathway 0 0 0.427692308 yes urine_cometabolism kegg 0.0908 NA no up no no up up L-Phenylalanine+urine Porphyrin and chlorophyll metabolism -0.457894737 0 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Prevotella -0.475708081 0 0 acetate-producing urine_cometabolism Genus 0.0908 0.287 no up no no no no L-Phenylalanine+urine Progesterone-mediated oocyte maturation 0.505263158 0 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Protein processing in endoplasmic reticulum 0 0.545614035 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Proteoglycans in cancer 0 0.485964912 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine PUFA%+blood 0.529411765 -0.774725275 0 urine_cometabolism serum_fattyacid 0.0908 0.0013 no up no dn no up L-Phenylalanine+urine Rheumatoid arthritis 0 0 -0.403846154 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Ribosome 0 0 0.414615385 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Ribosome biogenesis in eukaryotes 0 0.485964912 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine RNA degradation 0 0.585964912 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine RNA transport 0 0.484210526 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine Sarcosine+blood -0.49754902 0 0 urine_cometabolism serum_choline 0.0908 5.06E-05 no up no up up no L-Phenylalanine+urine SFA%+blood 0.490196078 -0.785714286 0 urine_cometabolism serum_fattyacid 0.0908 0.0236 no up no no up no L-Phenylalanine+urine Sphingolipid signaling pathway 0.456140351 0 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine TCA+stool 0 0 -0.512899897 urine_cometabolism stool_bileacids 0.0908 0.458 no up no no no no L-Phenylalanine+urine Transcriptional misregulation in cancer 0.543859649 0 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Phenylalanine+urine TUDCA+blood 0 0.598278863 0 yes urine_cometabolism serum_bileacids 0.0908 0.0282 no up no no no dn L-Phenylalanine+urine TXB2+blood 0 -0.613269028 0 yes urine_cometabolism serum_ARA 0.0908 0.0644 no up no dn no no L-Phenylalanine+urine UDCA+blood 0 0.571428571 0 yes urine_cometabolism serum_bileacids 0.0908 0.0939 no up no no no dn L-Phenylalanine+urine UFA%+blood 0 -0.862637363 0 urine_cometabolism serum_fattyacid 0.0908 0.0236 no up no no dn no L-Phenylalanine+urine Wnt signaling pathway 0 0.478947368 0 urine_cometabolism kegg 0.0908 NA no up no no no no L-Proline+blood 12-ketoDCA+blood 0.48290738 0 0 yes serum_aminoacids serum_bileacids 0.00265 0.517 up up no no no no L-Proline+blood "12,13-EPOME+blood" -0.545490999 0 0 yes serum_aminoacids serum_ARA 0.00265 0.901 up up no no no no L-Proline+blood 14:0/18:2-PC+blood 0 0 -0.424273504 yes serum_aminoacids serum_phospholipids 0.00265 0.102 up up no no up no L-Proline+blood 14:0+blood 0 0 -0.499487179 yes yes serum_aminoacids serum_fattyacid 0.00265 0.00572 up up no up no dn L-Proline+blood 16:0/16:0-PI+blood 0 0.512254902 0 yes serum_aminoacids serum_phospholipids 0.00265 0.358 up up no no no no L-Proline+blood 16:0/18:0-PC+blood 0 -0.551470588 0 yes serum_aminoacids serum_phospholipids 0.00265 0.521 up up no no no no L-Proline+blood 16:0/18:0-PS+blood -0.479699248 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.377 up up no no no no L-Proline+blood 16:0/18:2-PI+blood 0 0.700980392 0 yes serum_aminoacids serum_phospholipids 0.00265 0.269 up up no no no no L-Proline+blood 16:0/20:4-PC+blood 0 -0.647058824 0 yes serum_aminoacids serum_phospholipids 0.00265 0.0262 up up no no up no L-Proline+blood 16:0/22:6-PC+blood 0 -0.703431373 0 yes serum_aminoacids serum_phospholipids 0.00265 4.53E-05 up up no no up up L-Proline+blood 16:0+blood -0.517293233 0 -0.460512821 yes yes serum_aminoacids serum_fattyacid 0.00265 0.00876 up up no up no no L-Proline+blood 16:1+blood -0.566917293 0 0 yes yes serum_aminoacids serum_fattyacid 0.00265 0.0186 up up no no no dn L-Proline+blood 18:0/18:0-PE+blood 0 0.490196078 0 yes serum_aminoacids serum_phospholipids 0.00265 0.00896 up up no up up no L-Proline+blood 18:0/18:0-PS+blood -0.529323308 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.00617 up up no no up no L-Proline+blood 18:0/18:1-PE+blood 0 0.544117647 0 yes serum_aminoacids serum_phospholipids 0.00265 0.00716 up up no up up no L-Proline+blood 18:0/18:1-PG+blood 0 0.492647059 0 yes serum_aminoacids serum_phospholipids 0.00265 0.000842 up up no no up no L-Proline+blood 18:0/18:2-PI+blood -0.490225564 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.179 up up no no no no L-Proline+blood 18:0/20:4-PC+blood 0 -0.757352941 0 yes serum_aminoacids serum_phospholipids 0.00265 0.454 up up no no no no L-Proline+blood 18:0/20:5-PC+blood 0 -0.602941176 0 yes serum_aminoacids serum_phospholipids 0.00265 0.17 up up no no no no L-Proline+blood 18:0/22:6-PA+blood 0 -0.566176471 0 yes serum_aminoacids serum_phospholipids 0.00265 0.22 up up no no no no L-Proline+blood 18:0/22:6-PI+blood -0.533834586 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.425 up up no no no no L-Proline+blood 18:1/18:0-PE+blood 0 0.571078431 0 yes serum_aminoacids serum_phospholipids 0.00265 1.39E-06 up up no up up no L-Proline+blood 18:1/18:0-PS+blood -0.47518797 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.193 up up no no no no L-Proline+blood 18:1/18:2-PE+blood 0 0.585784314 0 yes serum_aminoacids serum_phospholipids 0.00265 0.000293 up up no up up no L-Proline+blood 18:1/20:4-PC+blood 0 -0.659313725 0 yes serum_aminoacids serum_phospholipids 0.00265 0.582 up up no no no no L-Proline+blood 18:1+blood -0.562406015 0 -0.468717949 yes yes serum_aminoacids serum_fattyacid 0.00265 0.00202 up up no up no dn L-Proline+blood 18:2-LPE+blood 0.458646617 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.112 up up no no no no L-Proline+blood 18:3-LPC+blood 0 0 0.405128205 yes serum_aminoacids serum_phospholipids 0.00265 0.147 up up no no no no L-Proline+blood 18:3/18:2-PC+blood -0.469172932 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.0394 up up no no no up L-Proline+blood 18:3n3+blood -0.526315789 0 0 yes serum_aminoacids serum_fattyacid 0.00265 0.291 up up no no no no L-Proline+blood 20:0/20:4-PE+blood 0 0.534313725 0 yes serum_aminoacids serum_phospholipids 0.00265 0.00128 up up no up up no L-Proline+blood 20:0+blood 0 -0.558823529 0 yes yes serum_aminoacids serum_fattyacid 0.00265 0.000278 up up no dn no up L-Proline+blood 20:1-LPE+blood 0 -0.656862745 0 yes serum_aminoacids serum_phospholipids 0.00265 0.465 up up no no no no L-Proline+blood 20:1/20:4-PE+blood -0.568421053 0 -0.496068376 yes serum_aminoacids serum_phospholipids 0.00265 0.0042 up up no up up no L-Proline+blood 20:2/18:1-PE+blood -0.551879699 0.578431373 -0.483076923 yes serum_aminoacids serum_phospholipids 0.00265 0.00208 up up no up up no L-Proline+blood 20:3/16:0-PC+blood 0 -0.651960784 0 yes serum_aminoacids serum_phospholipids 0.00265 0.00405 up up no no up up L-Proline+blood 20:3/18:0-PC+blood 0 -0.607843137 0 yes serum_aminoacids serum_phospholipids 0.00265 0.296 up up no no no no L-Proline+blood 20:3n6+blood 0 0 -0.491965812 yes serum_aminoacids serum_fattyacid 0.00265 0.0884 up up no up no no L-Proline+blood 20:4-LPE+blood 0 -0.681372549 0 yes serum_aminoacids serum_phospholipids 0.00265 0.552 up up no no no no L-Proline+blood 20:4n6+blood 0 -0.598039216 0 yes serum_aminoacids serum_fattyacid 0.00265 0.133 up up no no no no L-Proline+blood 20:5/18:0-PC+blood 0 -0.700980392 0 yes serum_aminoacids serum_phospholipids 0.00265 3.97E-06 up up no no up up L-Proline+blood 22:0/16:0-PE+blood 0 -0.644607843 0 yes serum_aminoacids serum_phospholipids 0.00265 0.091 up up no no no up L-Proline+blood 22:6n3+blood 0 -0.522058824 0 yes serum_aminoacids serum_fattyacid 0.00265 0.792 up up no no no no L-Proline+blood 24:0+blood -0.697744361 0 0 yes serum_aminoacids serum_fattyacid 0.00265 0.034 up up no dn no up L-Proline+blood AA+blood -0.517293233 0 0 yes serum_aminoacids serum_ARA 0.00265 0.212 up up no no no no L-Proline+blood Adipocytokine signaling pathway 0.714035088 0 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Alzheimer disease 0 0.523529412 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood AMPK signaling pathway 0.71754386 0 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Amyotrophic lateral sclerosis 0 0.5 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Bifidobacterium -0.555848102 0.56529747 0 yes acetate-producing serum_aminoacids Genus 0.00265 0.105 up up no no dn no L-Proline+blood Blautia -0.536842105 0 0 yes acetate-producing serum_aminoacids Genus 0.00265 1.36E-05 up up no up dn dn L-Proline+blood CA+blood 0.583678116 0 0 yes serum_aminoacids serum_bileacids 0.00265 0.606 up up no no no no L-Proline+blood Cardiac muscle contraction 0 0.532352941 0 yes serum_aminoacids kegg 0.00265 NA up up no no no up L-Proline+blood Cholinergic synapse 0 0 0.421538462 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Chronic myeloid leukemia 0.480701754 0 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Clostridium -0.492996205 0 0 yes serum_aminoacids Genus 0.00265 0.925 up up no no no no L-Proline+blood d18:0-16:0-SM+blood -0.490225564 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.202 up up no no no no L-Proline+blood d18:0-18:3-SM+blood -0.446616541 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.0879 up up no no dn no L-Proline+blood d18:1-14:0-SM+blood -0.538345865 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.94 up up no no no no L-Proline+blood d18:1-14:1-SM+blood -0.491729323 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.0952 up up no no dn no L-Proline+blood d18:1-16:0-SM+blood -0.448120301 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.14 up up no no no no L-Proline+blood d18:1-16:1-SM+blood -0.621052632 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.2 up up no no no no L-Proline+blood d18:1-20:0-SM+blood -0.541353383 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.933 up up no no no no L-Proline+blood d18:1-22:1-SM+blood -0.538345865 0 0 yes serum_aminoacids serum_phospholipids 0.00265 0.222 up up no no no no L-Proline+blood Diabetic cardiomyopathy 0 0.544117647 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Dorea 0 0.482843137 0 yes serum_aminoacids Genus 0.00265 0.00362 up up no up no dn L-Proline+blood Fc gamma R-mediated phagocytosis -0.471929825 0 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood GCA+blood 0 0.522058824 0 yes yes serum_aminoacids serum_bileacids 0.00265 0.16 up up no no no no L-Proline+blood GCDCA+blood 0 0.62745098 0 yes serum_aminoacids serum_bileacids 0.00265 0.31 up up no no no no L-Proline+blood GCDCA+stool 0 0.690909091 0 yes yes serum_aminoacids stool_bileacids 0.00265 0.0471 up up no no dn no L-Proline+blood HCA+blood 0.473946892 0 0.422197232 yes serum_aminoacids serum_bileacids 0.00265 0.544 up up no no no no L-Proline+blood HCA+stool -0.576923077 0 0 yes serum_aminoacids stool_bileacids 0.00265 0.155 up up no no no no L-Proline+blood Huntington disease 0 0.517647059 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood iso-LCA+blood 0.547892798 0 0.526040018 yes serum_aminoacids serum_bileacids 0.00265 0.507 up up no no no no L-Proline+blood Kaposi sarcoma-associated herpesvirus infection 0.578947368 0.547058824 0 yes serum_aminoacids kegg 0.00265 NA up up no no no dn L-Proline+blood L-2-Aminobutyric acid+blood 0 -0.507352941 0 yes yes serum_aminoacids serum_aminoacids 0.00265 0.000328 up up no up up no L-Proline+blood L-Alanine+blood 0.521804511 0 0 yes yes serum_aminoacids serum_aminoacids 0.00265 0.00138 up up no up up no L-Proline+blood L-Citrulline+blood 0.45112782 0 0 yes serum_aminoacids serum_aminoacids 0.00265 0.534 up up no no no no L-Proline+blood L-Glutamine+blood 0.603007519 0 0 yes serum_aminoacids serum_aminoacids 0.00265 0.639 up up no no no no L-Proline+blood L-Ornithine+blood 0.551879699 0 0.457094017 yes serum_aminoacids serum_aminoacids 0.00265 0.175 up up no no no no L-Proline+blood Legionellosis 0 0 -0.444615385 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Leishmaniasis 0 0 -0.420769231 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Lipid and atherosclerosis -0.545614035 0 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Longevity regulating pathway 0.615789474 0 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Longevity regulating pathway - multiple species -0.657894737 0 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood MAPK signaling pathway 0 -0.579411765 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Mitophagy - animal 0.526315789 0.670588235 -0.454615385 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood mTOR signaling pathway 0 0 -0.428461538 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Olfactory transduction -0.524561404 0 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Oxidative phosphorylation 0 0.573529412 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Parabacteroides 0 -0.740196078 0 yes serum_aminoacids Genus 0.00265 4.19E-05 up up no no up up L-Proline+blood Parkinson disease 0 0.635294118 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Pathways of neurodegeneration - multiple diseases 0 0.635294118 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Peroxisome -0.456140351 0 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Phenylacetic acid+stool 0 -0.609090909 0 yes serum_aminoacids stool_cometabolism 0.00265 0.785 up up no no no no L-Proline+blood Prevotella 0 0 0.538137378 yes acetate-producing serum_aminoacids Genus 0.00265 0.287 up up no no no no L-Proline+blood Relaxin signaling pathway 0.480701754 0 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Roseburia 0 0.611894658 0 yes butyrate-producing serum_aminoacids Genus 0.00265 0.495 up up no no no no L-Proline+blood Ruminococcus 0 0.532188941 0 yes serum_aminoacids Genus 0.00265 0.0679 up up no no no dn L-Proline+blood Salmonella infection -0.456140351 0 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Shigellosis 0.549122807 0.588235294 -0.456153846 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood TCA+stool 0 0.663636364 0 yes serum_aminoacids stool_bileacids 0.00265 0.458 up up no no no no L-Proline+blood Ubiquitin mediated proteolysis 0.473684211 0.6 -0.471538462 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Proline+blood Vascular smooth muscle contraction 0 0.526470588 0 yes serum_aminoacids kegg 0.00265 NA up up no no no no L-Threonine+blood 12-ketoDCA+blood 0 0 -0.51656554 serum_aminoacids serum_bileacids 0.0538 0.517 dn no up no no no L-Threonine+blood 14:0/16:0-PC+blood 0 -0.607843137 0 serum_aminoacids serum_phospholipids 0.0538 0.0358 dn no up no up no L-Threonine+blood 14:0/18:2-PC+blood -0.44962406 -0.664215686 0 serum_aminoacids serum_phospholipids 0.0538 0.102 dn no up no up no L-Threonine+blood 14:0+blood -0.479699248 0 0 yes serum_aminoacids serum_fattyacid 0.0538 0.00572 dn no up up no dn L-Threonine+blood 16:0/16:0-PI+blood -0.496240602 0 -0.423589744 serum_aminoacids serum_phospholipids 0.0538 0.358 dn no up no no no L-Threonine+blood 16:0/18:0-PS+blood -0.55037594 0 0 serum_aminoacids serum_phospholipids 0.0538 0.377 dn no up no no no L-Threonine+blood 16:0/20:4-PI+blood -0.526315789 0 0 serum_aminoacids serum_phospholipids 0.0538 0.558 dn no up no no no L-Threonine+blood 16:0+blood 0 -0.50245098 0 yes serum_aminoacids serum_fattyacid 0.0538 0.00876 dn no up up no no L-Threonine+blood 18:0-LPA+blood 0 0.482843137 0 serum_aminoacids serum_phospholipids 0.0538 0.0725 dn no up no dn no L-Threonine+blood 18:0/18:0-PS+blood -0.593984962 0 0 serum_aminoacids serum_phospholipids 0.0538 0.00617 dn no up no up no L-Threonine+blood 18:0/18:2-PI+blood -0.505263158 0 0 serum_aminoacids serum_phospholipids 0.0538 0.179 dn no up no no no L-Threonine+blood 18:0/22:6-PE+blood -0.481203008 0 0 serum_aminoacids serum_phospholipids 0.0538 0.00022 dn no up up up no L-Threonine+blood 18:0/22:6-PI+blood -0.496240602 0 0 serum_aminoacids serum_phospholipids 0.0538 0.425 dn no up no no no L-Threonine+blood 18:1/16:0-PI+blood -0.45112782 0 0 serum_aminoacids serum_phospholipids 0.0538 0.793 dn no up no no no L-Threonine+blood 18:1/18:2-PI+blood 0 0.50245098 0 serum_aminoacids serum_phospholipids 0.0538 0.0164 dn no up dn no up L-Threonine+blood 18:1/20:4-PC+blood 0 0 0.411282051 serum_aminoacids serum_phospholipids 0.0538 0.582 dn no up no no no L-Threonine+blood 20:0/20:4-PE+blood -0.472180451 0 0 serum_aminoacids serum_phospholipids 0.0538 0.00128 dn no up up up no L-Threonine+blood 20:1/20:4-PE+blood -0.503759398 0 0 serum_aminoacids serum_phospholipids 0.0538 0.0042 dn no up up up no L-Threonine+blood 20:2/18:1-PE+blood -0.445112782 0 0 serum_aminoacids serum_phospholipids 0.0538 0.00208 dn no up up up no L-Threonine+blood 20:4-LPA+blood 0 0.485294118 0 serum_aminoacids serum_phospholipids 0.0538 0.398 dn no up no no no L-Threonine+blood 20:4/18:0-PE+blood -0.473684211 0 0 serum_aminoacids serum_phospholipids 0.0538 0.000755 dn no up up up no L-Threonine+blood 22:1-LPA+blood 0 0.5 0 serum_aminoacids serum_phospholipids 0.0538 0.00373 dn no up no up up L-Threonine+blood 24:0+blood -0.571428571 0 0 serum_aminoacids serum_fattyacid 0.0538 0.034 dn no up dn no up L-Threonine+blood 4-hydroxybenzoic acid+stool 0 0 0.54887218 serum_aminoacids stool_cometabolism 0.0538 0.0536 dn no up no dn no L-Threonine+blood 8-HETE+blood 0 0 0.504957265 serum_aminoacids serum_ARA 0.0538 0.741 dn no up no no no L-Threonine+blood ACA+stool 0 0 -0.446385084 serum_aminoacids stool_bileacids 0.0538 0.417 dn no up no no no L-Threonine+blood Acetic acid+stool 0 0.636363636 0 yes serum_aminoacids stool_scfa 0.0538 0.0656 dn no up dn no no L-Threonine+blood Adipocytokine signaling pathway 0.656140351 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Asthma 0.49122807 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Autophagy - animal 0 0 0.485384615 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Bifidobacterium -0.66265518 0 0 acetate-producing serum_aminoacids Genus 0.0538 0.105 dn no up no dn no L-Threonine+blood Butyricimonas 0 -0.667934488 0 butyrate-producing serum_aminoacids Genus 0.0538 0.17 dn no up no no no L-Threonine+blood Cell cycle -0.48245614 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Central carbon metabolism in cancer -0.701754386 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Chemokine signaling pathway 0 0 -0.429230769 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Choline metabolism in cancer 0 0 0.510769231 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Cholinergic synapse 0 0 0.472307692 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Colorectal cancer 0 -0.623529412 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Cystine+blood 0.541353383 0 0 yes serum_aminoacids serum_aminoacids 0.0538 0.00028 dn no up up up no L-Threonine+blood d18:1-14:0-SM+blood -0.673684211 0 0 serum_aminoacids serum_phospholipids 0.0538 0.94 dn no up no no no L-Threonine+blood d18:1-14:1-SM+blood -0.580451128 0 0 serum_aminoacids serum_phospholipids 0.0538 0.0952 dn no up no dn no L-Threonine+blood DHA+blood -0.535338346 0 0 serum_aminoacids serum_ARA 0.0538 0.872 dn no up no no no L-Threonine+blood DMG+blood 0.460150376 0 0 serum_aminoacids serum_choline 0.0538 0.909 dn no up no no no L-Threonine+blood Estrogen signaling pathway -0.519298246 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Gemmiger 0 -0.533171143 0 butyrate-producing serum_aminoacids Genus 0.0538 0.595 dn no up no no no L-Threonine+blood Glioma 0 0 0.426153846 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Glutamatergic synapse 0.477192982 0 0 serum_aminoacids kegg 0.0538 NA dn no up no up up L-Threonine+blood Glycolysis / Gluconeogenesis -0.505263158 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood HCA+blood 0 -0.488533119 0 serum_aminoacids serum_bileacids 0.0538 0.544 dn no up no no no L-Threonine+blood Hypotaurine+blood 0 0 0.472136752 serum_aminoacids serum_aminoacids 0.0538 0.933 dn no up no no no L-Threonine+blood Intestinal immune network for IgA production 0.519298246 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Kaposi sarcoma-associated herpesvirus infection 0.550877193 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no dn L-Threonine+blood L-Alanine+blood 0.445112782 0 0 yes serum_aminoacids serum_aminoacids 0.0538 0.00138 dn no up up up no L-Threonine+blood L-Arginine+blood 0.557894737 0 0 serum_aminoacids serum_aminoacids 0.0538 0.316 dn no up no no no L-Threonine+blood L-Asparagine+blood 0.457142857 0.656862745 0.591111111 serum_aminoacids serum_aminoacids 0.0538 0.784 dn no up no no no L-Threonine+blood L-Citrulline+blood 0.497744361 0 0.405811966 serum_aminoacids serum_aminoacids 0.0538 0.534 dn no up no no no L-Threonine+blood L-Glutamine+blood 0.595488722 0 0 serum_aminoacids serum_aminoacids 0.0538 0.639 dn no up no no no L-Threonine+blood L-Lysine+blood 0 0.524509804 0 yes serum_aminoacids serum_aminoacids 0.0538 0.0107 dn no up no up no L-Threonine+blood L-Methionine+blood 0 0.681372549 0.466666667 serum_aminoacids serum_aminoacids 0.0538 0.626 dn no up no no no L-Threonine+blood L-Ornithine+blood 0.645112782 0 0 serum_aminoacids serum_aminoacids 0.0538 0.175 dn no up no no no L-Threonine+blood L-Proline+blood 0.578947368 0 0 yes serum_aminoacids serum_aminoacids 0.0538 0.00265 dn no up up up no L-Threonine+blood Legionellosis -0.60877193 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Leishmaniasis -0.484210526 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Longevity regulating pathway - multiple species -0.598245614 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Morphine addiction 0.521052632 0 0 serum_aminoacids kegg 0.0538 NA dn no up no up up L-Threonine+blood Non-small cell lung cancer 0 0 0.405384615 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Phosphatidylinositol signaling system 0 0 0.432307692 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood PI3K-Akt signaling pathway -0.471929825 0 0 yes serum_aminoacids kegg 0.0538 NA dn no up no up up L-Threonine+blood Prevotella 0 -0.54349042 0 acetate-producing serum_aminoacids Genus 0.0538 0.287 dn no up no no no L-Threonine+blood Primary immunodeficiency -0.724561404 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Ras signaling pathway 0 0 0.416153846 yes serum_aminoacids kegg 0.0538 NA dn no up no up up L-Threonine+blood RNA transport -0.631578947 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Spliceosome -0.512280702 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Th1 and Th2 cell differentiation 0.561403509 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Th17 cell differentiation 0.570175439 0 0 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Threonine+blood Vasopressin-regulated water reabsorption 0 0 -0.407692308 serum_aminoacids kegg 0.0538 NA dn no up no no no L-Tryptophan+blood 12-HEPE+blood 0.457177049 -0.503856806 0 serum_aminoacids serum_ARA 0.164 0.312 no no no no no no L-Tryptophan+blood 14:0/20:4-PC+blood -0.47518797 0 0 serum_aminoacids serum_phospholipids 0.164 0.486 no no no no no no L-Tryptophan+blood 16:0/16:1-PI+blood 0 0 -0.408547009 serum_aminoacids serum_phospholipids 0.164 0.262 no no no no no no L-Tryptophan+blood 16:0/18:0-PC+blood 0 -0.541666667 0 serum_aminoacids serum_phospholipids 0.164 0.521 no no no no no no L-Tryptophan+blood 16:0/18:3-PC+blood -0.496240602 0 0 serum_aminoacids serum_phospholipids 0.164 0.00216 no no no no up up L-Tryptophan+blood 16:0/20:4-PI+blood 0 0 -0.531623932 serum_aminoacids serum_phospholipids 0.164 0.558 no no no no no no L-Tryptophan+blood 16:0/22:0-PE+blood 0 0 0.427008547 serum_aminoacids serum_phospholipids 0.164 0.00839 no no no dn no up L-Tryptophan+blood 18:0-LPE+blood 0 0 -0.478974359 serum_aminoacids serum_phospholipids 0.164 0.491 no no no no no no L-Tryptophan+blood 18:0/18:1-PE+blood -0.452631579 0 0 serum_aminoacids serum_phospholipids 0.164 0.00716 no no no up up no L-Tryptophan+blood 18:0/20:3-PI+blood 0.557894737 0 0 serum_aminoacids serum_phospholipids 0.164 0.377 no no no no no no L-Tryptophan+blood 18:2-LPA+blood 0 0.629901961 0 serum_aminoacids serum_phospholipids 0.164 0.00684 no no no dn no up L-Tryptophan+blood 18:3/16:0-PE+blood -0.530827068 0 0 serum_aminoacids serum_phospholipids 0.164 0.00149 no no no up up no L-Tryptophan+blood 18:3/18:2-PC+blood -0.642105263 0 0 serum_aminoacids serum_phospholipids 0.164 0.0394 no no no no no up L-Tryptophan+blood 18:3n6+blood -0.616541353 0 -0.556923077 serum_aminoacids serum_fattyacid 0.164 0.0463 no no no up no dn L-Tryptophan+blood 20:0+blood 0 -0.666666667 0 yes serum_aminoacids serum_fattyacid 0.164 0.000278 no no no dn no up L-Tryptophan+blood 20:1-LPE+blood 0 -0.534313725 0 serum_aminoacids serum_phospholipids 0.164 0.465 no no no no no no L-Tryptophan+blood 20:2-LPE+blood 0 -0.512254902 0 serum_aminoacids serum_phospholipids 0.164 0.177 no no no no no no L-Tryptophan+blood 20:2/18:1-PE+blood -0.452631579 0 0 serum_aminoacids serum_phospholipids 0.164 0.00208 no no no up up no L-Tryptophan+blood 20:2/18:3-PE+blood 0 -0.512254902 0 serum_aminoacids serum_phospholipids 0.164 0.0391 no no no up up no L-Tryptophan+blood 20:4-LPC+blood 0.535338346 0 0 serum_aminoacids serum_phospholipids 0.164 0.949 no no no no no no L-Tryptophan+blood 20:4/16:0-PE+blood 0 0 -0.453675214 serum_aminoacids serum_phospholipids 0.164 0.00529 no no no no up up L-Tryptophan+blood AGE-RAGE signaling pathway in diabetic complications 0.524561404 0 0 serum_aminoacids kegg 0.164 NA no no no no no no L-Tryptophan+blood Betaine+blood 0.472180451 0 0 serum_aminoacids serum_choline 0.164 0.857 no no no no no no L-Tryptophan+blood Bifidobacterium 0 0.567749953 0 acetate-producing serum_aminoacids Genus 0.164 0.105 no no no no dn no L-Tryptophan+blood Blautia 0 0.625 0 acetate-producing serum_aminoacids Genus 0.164 1.36E-05 no no no up dn dn L-Tryptophan+blood Breast cancer 0.456140351 0 0 serum_aminoacids kegg 0.164 NA no no no no no no L-Tryptophan+blood capric acid C6+blood 0 0 0.412649573 serum_aminoacids serum_scfa 0.164 0.433 no no no no no no L-Tryptophan+blood Carbon metabolism -0.473684211 0 0 serum_aminoacids kegg 0.164 NA no no no no no no L-Tryptophan+blood CDCA+blood 0 0 -0.418119658 serum_aminoacids serum_bileacids 0.164 0.506 no no no no no no L-Tryptophan+blood Choline metabolism in cancer 0.464912281 0 0 serum_aminoacids kegg 0.164 NA no no no no no no L-Tryptophan+blood Choline+blood 0.545864662 0.492647059 0 serum_aminoacids serum_choline 0.164 0.0395 no no no no up no L-Tryptophan+blood Cholinergic synapse 0 -0.626470588 0 serum_aminoacids kegg 0.164 NA no no no no no no L-Tryptophan+blood Coprococcus 0 0.5 0 butyrate-producing serum_aminoacids Genus 0.164 0.612 no no no no no no L-Tryptophan+blood Creatinine+blood 0.763909774 0.735294118 0 serum_aminoacids serum_choline 0.164 0.437 no no no no no no L-Tryptophan+blood Cysteine+blood 0 0 0.429059829 yes serum_aminoacids serum_aminoacids 0.164 1.81E-07 no no no dn up up L-Tryptophan+blood Cystine+blood 0 0.539215686 0 yes serum_aminoacids serum_aminoacids 0.164 0.00028 no no no up up no L-Tryptophan+blood d18:1-14:1-SM+blood -0.487218045 0 -0.526837607 serum_aminoacids serum_phospholipids 0.164 0.0952 no no no no dn no L-Tryptophan+blood d18:1-16:1-SM+blood 0 0 -0.434529915 serum_aminoacids serum_phospholipids 0.164 0.2 no no no no no no L-Tryptophan+blood decanoic acid C10+blood 0 0 0.452991453 serum_aminoacids serum_mcfa 0.164 6.64E-11 no no no dn dn no L-Tryptophan+blood DL-methionine sulfoxide+blood 0 0.595588235 0 serum_aminoacids serum_aminoacids 0.164 0.302 no no no no no no L-Tryptophan+blood DMG+blood 0 0.531862745 0.415384615 serum_aminoacids serum_choline 0.164 0.909 no no no no no no L-Tryptophan+blood Dorea 0 0.495098039 0 serum_aminoacids Genus 0.164 0.00362 no no no up no dn L-Tryptophan+blood Endocrine resistance 0.542105263 0 0 serum_aminoacids kegg 0.164 NA no no no no no no L-Tryptophan+blood ErbB signaling pathway 0.487719298 0 0 serum_aminoacids kegg 0.164 NA no no no no no no L-Tryptophan+blood Ethanolamine+blood 0 0 0.506324786 serum_aminoacids serum_aminoacids 0.164 0.122 no no no up no no L-Tryptophan+blood Fc epsilon RI signaling pathway 0.571929825 0 0 serum_aminoacids kegg 0.164 NA no no no no no no L-Tryptophan+blood GCDCA+stool 0 0.690909091 0 yes serum_aminoacids stool_bileacids 0.164 0.0471 no no no no dn no L-Tryptophan+blood GDCA+stool 0 0.619591585 0 serum_aminoacids stool_bileacids 0.164 0.656 no no no no no no L-Tryptophan+blood "Growth hormone synthesis, secretion and action" 0.585964912 0 0 serum_aminoacids kegg 0.164 NA no no no no no no L-Tryptophan+blood HDCA+blood 0.460374502 0 0 serum_aminoacids serum_bileacids 0.164 0.483 no no no no no no L-Tryptophan+blood heptanoic acid C7+blood 0 0 0.616410256 serum_aminoacids serum_mcfa 0.164 8.27E-11 no no no dn dn no L-Tryptophan+blood Human T-cell leukemia virus 1 infection -0.470175439 0 0 serum_aminoacids kegg 0.164 NA no no no no no no L-Tryptophan+blood Hypotaurine+blood 0 0 0.426324786 serum_aminoacids serum_aminoacids 0.164 0.933 no no no no no no L-Tryptophan+blood L-Alanine+blood 0 0.492647059 0 yes serum_aminoacids serum_aminoacids 0.164 0.00138 no no no up up no L-Tryptophan+blood L-Arginine+blood 0.491729323 0 0 serum_aminoacids serum_aminoacids 0.164 0.316 no no no no no no L-Tryptophan+blood L-Asparagine+blood 0 0 0.734700855 serum_aminoacids serum_aminoacids 0.164 0.784 no no no no no no L-Tryptophan+blood L-Citrulline+blood 0 0 0.458461538 serum_aminoacids serum_aminoacids 0.164 0.534 no no no no no no L-Tryptophan+blood L-Glutamic acid+blood 0.639097744 0.612745098 0 yes serum_aminoacids serum_aminoacids 0.164 6.20E-05 no no no up up no L-Tryptophan+blood L-Glutamine+blood 0 0.524509804 0.494700855 serum_aminoacids serum_aminoacids 0.164 0.639 no no no no no no L-Tryptophan+blood L-Histidine+blood 0.587969925 0 0.598632479 serum_aminoacids serum_aminoacids 0.164 0.109 no no no no no no L-Tryptophan+blood L-Isoleucine+blood 0.618045113 0.718137255 0.585641026 yes serum_aminoacids serum_aminoacids 0.164 5.47E-06 no no no up up no L-Tryptophan+blood L-Leucine+blood 0 0.536764706 0.526153846 yes serum_aminoacids serum_aminoacids 0.164 3.22E-05 no no no up up no L-Tryptophan+blood L-Lysine+blood 0.783458647 0.56372549 0.461196581 yes serum_aminoacids serum_aminoacids 0.164 0.0107 no no no no up no L-Tryptophan+blood L-Methionine+blood 0.822556391 0.68872549 0.771623932 serum_aminoacids serum_aminoacids 0.164 0.626 no no no no no no L-Tryptophan+blood L-Ornithine+blood 0 0 0.422222222 serum_aminoacids serum_aminoacids 0.164 0.175 no no no no no no L-Tryptophan+blood L-Phenylalanine+blood 0.809022556 0.803921569 0 yes serum_aminoacids serum_aminoacids 0.164 0.0103 no no no up up no L-Tryptophan+blood L-Phenylalanine+stool 0 0 0.669172932 serum_aminoacids stool_cometabolism 0.164 0.398 no no no no no no L-Tryptophan+blood L-Proline+blood 0 0.676470588 0 yes serum_aminoacids serum_aminoacids 0.164 0.00265 no no no up up no L-Tryptophan+blood L-Tryptophan+stool 0 0 0.511278195 serum_aminoacids stool_cometabolism 0.164 0.557 no no no no no no L-Tryptophan+blood L-Tyrosine+stool 0 0 0.693233083 serum_aminoacids stool_cometabolism 0.164 0.44 no no no no no no L-Tryptophan+blood Leishmaniasis -0.556140351 0 0 serum_aminoacids kegg 0.164 NA no no no no no no L-Tryptophan+blood Long-term depression 0 0 -0.412307692 serum_aminoacids kegg 0.164 NA no no no no no no L-Tryptophan+blood Non-small cell lung cancer 0.492982456 0 0 serum_aminoacids kegg 0.164 NA no no no no no no L-Tryptophan+blood Parabacteroides 0 -0.49754902 0 serum_aminoacids Genus 0.164 4.19E-05 no no no no up up L-Tryptophan+blood Phospholipase D signaling pathway 0.663157895 0 0 serum_aminoacids kegg 0.164 NA no no no no up up L-Tryptophan+blood Prolactin signaling pathway 0.594736842 0 0 serum_aminoacids kegg 0.164 NA no no no no no no L-Tryptophan+blood TCA+stool -0.602476498 0 0 serum_aminoacids stool_bileacids 0.164 0.458 no no no no no no L-Tryptophan+stool 4-hydroxybenzoic acid+stool 0 0.622377622 0 stool_cometabolism stool_cometabolism 0.557 0.0536 no no no no dn no L-Tryptophan+stool ACA+stool 0 -0.650443636 0 stool_cometabolism stool_bileacids 0.557 0.417 no no no no no no L-Tryptophan+stool Allograft rejection 0 0 -0.594579334 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Antigen processing and presentation 0 0 -0.529079616 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Apelin signaling pathway -0.547987616 0 0 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Autoimmune thyroid disease 0 0 -0.594579334 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Axon guidance 0 0 -0.437605872 stool_cometabolism kegg 0.557 NA no no no no up up L-Tryptophan+stool Butyric acid+stool -0.583075335 0 0 yes stool_cometabolism stool_scfa 0.557 0.102 no no no dn no no L-Tryptophan+stool Butyricicoccus 0 0 -0.525161207 butyrate-producing stool_cometabolism Genus 0.557 0.852 no no no no no no L-Tryptophan+stool CA+stool 0 0 -0.472332016 stool_cometabolism stool_bileacids 0.557 0.827 no no no no no no L-Tryptophan+stool CDCA+stool 0 0 -0.552371542 stool_cometabolism stool_bileacids 0.557 0.663 no no no no no no L-Tryptophan+stool Cell adhesion molecules 0 0 -0.596837945 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Cellular senescence 0 0 -0.593450028 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Coronavirus disease - COVID-19 -0.576883385 0 0 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool DCA+stool -0.574819401 -0.664335664 0 stool_cometabolism stool_bileacids 0.557 0.195 no no no no no no L-Tryptophan+stool EGFR tyrosine kinase inhibitor resistance -0.484004128 0 0 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Endocytosis 0 0 -0.587803501 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Epstein-Barr virus infection 0 0 -0.555053642 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Faecalibacterium 0 0 -0.428289032 butyrate-producing stool_cometabolism Genus 0.557 0.0039 no no no no dn dn L-Tryptophan+stool Gemmiger -0.54723807 0 0 butyrate-producing stool_cometabolism Genus 0.557 0.595 no no no no no no L-Tryptophan+stool Graft-versus-host disease 0 0 -0.603613778 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool GUDCA+stool 0.565668221 0 0 yes stool_cometabolism stool_bileacids 0.557 0.0085 no no no no dn no L-Tryptophan+stool Herpes simplex virus 1 infection 0 0 -0.470355731 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Human cytomegalovirus infection 0 0 -0.543760587 stool_cometabolism kegg 0.557 NA no no no no no dn L-Tryptophan+stool Human immunodeficiency virus 1 infection 0 0 -0.533596838 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Human papillomavirus infection 0 0 -0.523433089 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Human T-cell leukemia virus 1 infection 0 0 -0.511010728 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Indole-3-Acetic acid+stool 0.622291022 0 0.664031621 stool_cometabolism stool_cometabolism 0.557 0.304 no no no no no no L-Tryptophan+stool Influenza A 0.494324045 0 0 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Insulin signaling pathway -0.50877193 0 0 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool iso-DCA+stool -0.484004128 0 0 stool_cometabolism stool_bileacids 0.557 0.155 no no no no no no L-Tryptophan+stool Isobutyric acid+stool 0 0 0.640316206 stool_cometabolism stool_scfa 0.557 0.408 no no no no no no L-Tryptophan+stool Isovaleric acid+stool 0 0 0.602766798 stool_cometabolism stool_scfa 0.557 0.343 no no no no no no L-Tryptophan+stool L-Phenylalanine+stool 0.909184727 0.888111888 0.918972332 stool_cometabolism stool_cometabolism 0.557 0.398 no no no no no no L-Tryptophan+stool mTOR signaling pathway -0.583075335 0 0 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Natural killer cell mediated cytotoxicity 0 0 -0.558441558 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Neutrophil extracellular trap formation 0.583075335 0 0 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Pathogenic Escherichia coli infection 0.492260062 0 0 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Phagosome 0 0 -0.514398645 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Phospholipase D signaling pathway 0.486068111 0 0 stool_cometabolism kegg 0.557 NA no no no no up up L-Tryptophan+stool Prevotella -0.538778043 0 0 acetate-producing stool_cometabolism Genus 0.557 0.287 no no no no no no L-Tryptophan+stool Purine metabolism -0.533539732 0 0 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Renal cell carcinoma 0 0.627272727 0 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Ribosome -0.55624355 0 0 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Staphylococcus aureus infection 0.545923633 0 0 stool_cometabolism kegg 0.557 NA no no no up no no L-Tryptophan+stool Tuberculosis 0.554179567 0 0 stool_cometabolism kegg 0.557 NA no no no no no dn L-Tryptophan+stool Type I diabetes mellitus 0 0 -0.593450028 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Viral carcinogenesis 0 0 -0.559570864 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Viral myocarditis 0 0 -0.57312253 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool Yersinia infection 0.481940144 0 0 stool_cometabolism kegg 0.557 NA no no no no no no L-Tryptophan+stool ¦Ø-MCA+stool 0 -0.616041759 0 stool_cometabolism stool_bileacids 0.557 0.919 no no no no no no L-Tryptophan+urine 16:0/16:0-PC+blood 0.644607843 0 0 urine_cometabolism serum_phospholipids 0.226 0.00079 no no no no up up L-Tryptophan+urine 16:0/18:0-PS+blood -0.512254902 0 0 urine_cometabolism serum_phospholipids 0.226 0.377 no no no no no no L-Tryptophan+urine 16:0/18:1-PC+blood 0.735294118 0 0 urine_cometabolism serum_phospholipids 0.226 6.15E-07 no no no up up up L-Tryptophan+urine 16:0/18:2-PC+blood 0.68872549 0 0 urine_cometabolism serum_phospholipids 0.226 3.24E-06 no no no no up up L-Tryptophan+urine 16:0/18:2-PI+blood -0.485294118 0 0 urine_cometabolism serum_phospholipids 0.226 0.269 no no no no no no L-Tryptophan+urine 16:0/20:3-PC+blood 0.693627451 0 0 urine_cometabolism serum_phospholipids 0.226 5.43E-06 no no no no up up L-Tryptophan+urine 16:0/20:4-PC+blood 0.593137255 0 0 urine_cometabolism serum_phospholipids 0.226 0.0262 no no no no up no L-Tryptophan+urine 16:0/22:6-PE+blood -0.517156863 0 0 urine_cometabolism serum_phospholipids 0.226 0.000934 no no no up up no L-Tryptophan+urine 16:1/16:0-PC+blood 0.485294118 -0.604395604 0 urine_cometabolism serum_phospholipids 0.226 0.0215 no no no no up up L-Tryptophan+urine 18:0-LPE+blood -0.678921569 0 0 urine_cometabolism serum_phospholipids 0.226 0.491 no no no no no no L-Tryptophan+urine 18:0/16:0-PC+blood 0.723039216 0 0 urine_cometabolism serum_phospholipids 0.226 9.64E-07 no no no up up up L-Tryptophan+urine 18:0/18:1-PE+blood -0.541666667 0 0 urine_cometabolism serum_phospholipids 0.226 0.00716 no no no up up no L-Tryptophan+urine 18:0/18:2-PC+blood 0.605392157 0 0 urine_cometabolism serum_phospholipids 0.226 1.74E-06 no no no no up up L-Tryptophan+urine 18:0/20:4-PC+blood 0.68627451 0 0 urine_cometabolism serum_phospholipids 0.226 0.454 no no no no no no L-Tryptophan+urine 18:0/22:6-PE+blood -0.531862745 0 0 urine_cometabolism serum_phospholipids 0.226 0.00022 no no no up up no L-Tryptophan+urine 18:1-LPC+blood 0.492647059 0 0 urine_cometabolism serum_phospholipids 0.226 0.179 no no no no no no L-Tryptophan+urine 18:1/16:0-PC+blood 0.693627451 0 0 urine_cometabolism serum_phospholipids 0.226 2.43E-05 no no no no up up L-Tryptophan+urine 18:1/18:0-PC+blood 0.656862745 0 0 urine_cometabolism serum_phospholipids 0.226 1.83E-06 no no no no up up L-Tryptophan+urine 18:1/18:1-PC+blood 0.781862745 0 0 urine_cometabolism serum_phospholipids 0.226 1.34E-05 no no no no up up L-Tryptophan+urine 18:1/18:1-PE+blood -0.625 0 0 urine_cometabolism serum_phospholipids 0.226 1.03E-05 no no no up up no L-Tryptophan+urine 18:1/20:4-PC+blood 0.56372549 0 0 urine_cometabolism serum_phospholipids 0.226 0.582 no no no no no no L-Tryptophan+urine 18:1+blood 0 0 -0.446753247 yes urine_cometabolism serum_fattyacid 0.226 0.00202 no no no up no dn L-Tryptophan+urine 18:2/16:0-PC+blood 0.610294118 0 0 urine_cometabolism serum_phospholipids 0.226 8.67E-05 no no no no up up L-Tryptophan+urine 18:2/18:2-PC+blood 0.482843137 0 0 urine_cometabolism serum_phospholipids 0.226 1.98E-05 no no no dn up up L-Tryptophan+urine 18:2/20:4-PC+blood 0.575980392 0 0 urine_cometabolism serum_phospholipids 0.226 0.0145 no no no no no up L-Tryptophan+urine 2-hydroxyhippuric acid+urine -0.50075188 -0.51754386 -0.44957265 urine_cometabolism urine_cometabolism 0.226 0.215 no no no no no no L-Tryptophan+urine 2-hydroxyphenylacetic acid+urine 0 0 -0.455726496 urine_cometabolism urine_cometabolism 0.226 0.763 no no no no no no L-Tryptophan+urine 20:0+blood 0.566176471 0 0 yes urine_cometabolism serum_fattyacid 0.226 0.000278 no no no dn no up L-Tryptophan+urine 20:3/16:0-PC+blood 0.629901961 0 0 urine_cometabolism serum_phospholipids 0.226 0.00405 no no no no up up L-Tryptophan+urine 20:3/18:0-PC+blood 0 0 -0.5 urine_cometabolism serum_phospholipids 0.226 0.296 no no no no no no L-Tryptophan+urine 22:6n3+blood 0 0 -0.485714286 urine_cometabolism serum_fattyacid 0.226 0.792 no no no no no no L-Tryptophan+urine 3-Hydroxy-L-kynurenine+urine 0.642105263 0.675438596 0.489230769 urine_cometabolism urine_cometabolism 0.226 0.401 no no no no no no L-Tryptophan+urine Anaerostipes 0 0.506337545 0 butyrate-producing urine_cometabolism Genus 0.226 0.568 no no no no no no L-Tryptophan+urine Apelin signaling pathway 0 0 0.407692308 urine_cometabolism kegg 0.226 NA no no no no no no L-Tryptophan+urine Clostridium -0.527284967 0 0 urine_cometabolism Genus 0.226 0.925 no no no no no no L-Tryptophan+urine Collinsella -0.563253651 0 0 urine_cometabolism Genus 0.226 0.128 no no no no no no L-Tryptophan+urine Cytosolic DNA-sensing pathway 0.503508772 0 0 urine_cometabolism kegg 0.226 NA no no no no no no L-Tryptophan+urine DL-methionine sulfoxide+blood -0.541666667 0 0 urine_cometabolism serum_aminoacids 0.226 0.302 no no no no no no L-Tryptophan+urine EGFR tyrosine kinase inhibitor resistance 0 0 0.41 urine_cometabolism kegg 0.226 NA no no no no no no L-Tryptophan+urine Fluid shear stress and atherosclerosis 0 0 -0.427692308 urine_cometabolism kegg 0.226 NA no no no no no no L-Tryptophan+urine Glucagon signaling pathway 0 0 0.473076923 urine_cometabolism kegg 0.226 NA no no no no no no L-Tryptophan+urine Glycine+blood 0 -0.675824176 0 urine_cometabolism serum_aminoacids 0.226 0.00408 no no no dn no up L-Tryptophan+urine Homovanillic acid+urine -0.572932331 0 0 urine_cometabolism urine_cometabolism 0.226 0.45 no no no no no no L-Tryptophan+urine Indole-3-Acetic acid+urine 0 -0.49122807 0 urine_cometabolism urine_cometabolism 0.226 0.657 no no no no no no L-Tryptophan+urine iso-DCA+blood 0.612745098 0 0 urine_cometabolism serum_bileacids 0.226 0.38 no no no no no no L-Tryptophan+urine L-Phenylalanine+urine 0.715789474 0.840350877 0.781880342 urine_cometabolism urine_cometabolism 0.226 0.0908 no no no no up no L-Tryptophan+urine L-Threonine+blood 0 -0.593406593 0 urine_cometabolism serum_aminoacids 0.226 0.0538 no no no dn no up L-Tryptophan+urine Lachnospira -0.457142857 0 0 butyrate-producing urine_cometabolism Genus 0.226 0.279 no no no no no no L-Tryptophan+urine Lysosome 0 0 -0.434615385 urine_cometabolism kegg 0.226 NA no no no no no no L-Tryptophan+urine mRNA surveillance pathway 0 0 0.424615385 urine_cometabolism kegg 0.226 NA no no no no no no L-Tryptophan+urine MUFA%+blood 0 -0.692307692 0 urine_cometabolism serum_fattyacid 0.226 0.00142 no no no up no dn L-Tryptophan+urine n3+blood 0 0 -0.44025974 urine_cometabolism serum_fattyacid 0.226 0.806 no no no no no no L-Tryptophan+urine Necroptosis 0 0.514035088 0 urine_cometabolism kegg 0.226 NA no no no no no no L-Tryptophan+urine PI3K-Akt signaling pathway 0 0 0.43 yes urine_cometabolism kegg 0.226 NA no no no no up up L-Tryptophan+urine PUFA%+blood 0.647058824 -0.681318681 0 urine_cometabolism serum_fattyacid 0.226 0.0013 no no no dn no up L-Tryptophan+urine Pyramidobacter 0 0 0.428768601 urine_cometabolism Genus 0.226 0.45 no no no no no no L-Tryptophan+urine RNA transport 0 0 0.441538462 urine_cometabolism kegg 0.226 NA no no no no no no L-Tryptophan+urine SFA%+blood 0.625 -0.648351648 0 urine_cometabolism serum_fattyacid 0.226 0.0236 no no no no up no L-Tryptophan+urine T cell receptor signaling pathway 0 0 0.503846154 urine_cometabolism kegg 0.226 NA no no no no no no L-Tryptophan+urine TCA+stool 0 0 -0.488132095 urine_cometabolism stool_bileacids 0.226 0.458 no no no no no no L-Tryptophan+urine TMAO+blood 0 -0.565934066 0 urine_cometabolism serum_choline 0.226 0.00706 no no no up up no L-Tryptophan+urine TUDCA+blood -0.550899665 0 0 yes urine_cometabolism serum_bileacids 0.226 0.0282 no no no no no dn L-Tryptophan+urine TXB2+blood 0 -0.767967522 0 yes urine_cometabolism serum_ARA 0.226 0.0644 no no no dn no no L-Tryptophan+urine UFA%+blood 0.568627451 -0.752747253 0 urine_cometabolism serum_fattyacid 0.226 0.0236 no no no no dn no L-Tyrosine+blood 11-HETE+blood 0 0.533426676 0 yes serum_aminoacids serum_ARA 0.00913 0.464 up up no no no no L-Tyrosine+blood 12-HEPE+blood 0.522488056 -0.490684079 0 yes serum_aminoacids serum_ARA 0.00913 0.312 up up no no no no L-Tyrosine+blood 15-HETE+blood 0 0 -0.423215221 yes serum_aminoacids serum_ARA 0.00913 0.819 up up no no no no L-Tyrosine+blood 16:0/16:0-PI+blood 0 0.492647059 0 yes serum_aminoacids serum_phospholipids 0.00913 0.358 up up no no no no L-Tyrosine+blood 16:0/16:1-PC+blood 0 0.49754902 0 yes serum_aminoacids serum_phospholipids 0.00913 0.00283 up up no up up no L-Tyrosine+blood 16:0/16:1-PI+blood 0 0.556372549 0 yes serum_aminoacids serum_phospholipids 0.00913 0.262 up up no no no no L-Tyrosine+blood 16:1/18:2-PG+blood 0.445112782 0 0 yes serum_aminoacids serum_phospholipids 0.00913 1.40E-08 up up no no up up L-Tyrosine+blood 18:0-LPE+blood 0 0 -0.427692308 yes serum_aminoacids serum_phospholipids 0.00913 0.491 up up no no no no L-Tyrosine+blood 18:0/18:0-PE+blood -0.527819549 0 0 yes serum_aminoacids serum_phospholipids 0.00913 0.00896 up up no up up no L-Tyrosine+blood 18:0/18:1-PE+blood -0.523308271 0 0 yes serum_aminoacids serum_phospholipids 0.00913 0.00716 up up no up up no L-Tyrosine+blood 18:0/20:3-PI+blood 0.667669173 0 0 yes serum_aminoacids serum_phospholipids 0.00913 0.377 up up no no no no L-Tyrosine+blood 18:0/20:4-PC+blood 0 -0.541666667 0 yes serum_aminoacids serum_phospholipids 0.00913 0.454 up up no no no no L-Tyrosine+blood 18:0/20:4-PI+blood 0.478195489 0 0 yes serum_aminoacids serum_phospholipids 0.00913 0.167 up up no no no no L-Tyrosine+blood 18:0/20:5-PC+blood 0 -0.495098039 0 yes serum_aminoacids serum_phospholipids 0.00913 0.17 up up no no no no L-Tyrosine+blood 18:1-LPC+blood 0 0 -0.473504274 yes serum_aminoacids serum_phospholipids 0.00913 0.179 up up no no no no L-Tyrosine+blood 18:1/16:0-PE+blood -0.457142857 0 0 yes serum_aminoacids serum_phospholipids 0.00913 0.000182 up up no up up no L-Tyrosine+blood 18:1/18:2-PE+blood 0 0 -0.442051282 yes serum_aminoacids serum_phospholipids 0.00913 0.000293 up up no up up no L-Tyrosine+blood 18:2-LPE+blood 0 0 -0.471452991 yes serum_aminoacids serum_phospholipids 0.00913 0.112 up up no no no no L-Tyrosine+blood 18:3/16:0-PE+blood -0.461654135 0 0 yes serum_aminoacids serum_phospholipids 0.00913 0.00149 up up no up up no L-Tyrosine+blood 18:3n6+blood -0.615037594 0 0 yes serum_aminoacids serum_fattyacid 0.00913 0.0463 up up no up no dn L-Tyrosine+blood 20:0/20:5-PC+blood 0.487218045 0 0 yes serum_aminoacids serum_phospholipids 0.00913 0.882 up up no no no no L-Tyrosine+blood 20:0+blood 0 -0.536764706 0 yes yes serum_aminoacids serum_fattyacid 0.00913 0.000278 up up no dn no up L-Tyrosine+blood 20:1-LPE+blood 0 -0.571078431 0 yes serum_aminoacids serum_phospholipids 0.00913 0.465 up up no no no no L-Tyrosine+blood 20:2-LPC+blood 0.64962406 0 0 yes serum_aminoacids serum_phospholipids 0.00913 0.119 up up no no no up L-Tyrosine+blood 20:3/18:0-PI+blood 0.505263158 0 0 yes serum_aminoacids serum_phospholipids 0.00913 0.289 up up no no no no L-Tyrosine+blood 20:3n6+blood 0 0.56372549 0 yes serum_aminoacids serum_fattyacid 0.00913 0.0884 up up no up no no L-Tyrosine+blood 20:4-LPC+blood 0 -0.490196078 0 yes serum_aminoacids serum_phospholipids 0.00913 0.949 up up no no no no L-Tyrosine+blood 20:4-LPE+blood 0 -0.558823529 0 yes serum_aminoacids serum_phospholipids 0.00913 0.552 up up no no no no L-Tyrosine+blood 20:4n6+blood 0 -0.487745098 0 yes serum_aminoacids serum_fattyacid 0.00913 0.133 up up no no no no L-Tyrosine+blood Adrenergic signaling in cardiomyocytes 0.559649123 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no up L-Tyrosine+blood Alzheimer disease 0.466666667 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Apoptosis -0.48245614 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Arrhythmogenic right ventricular cardiomyopathy -0.519298246 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no up up L-Tyrosine+blood Asthma 0 0 -0.519230769 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Bifidobacterium 0 0.605763449 0 yes acetate-producing serum_aminoacids Genus 0.00913 0.105 up up no no dn no L-Tyrosine+blood Biosynthesis of amino acids -0.584210526 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Blautia 0 0.553921569 0 yes acetate-producing serum_aminoacids Genus 0.00913 1.36E-05 up up no up dn dn L-Tyrosine+blood Butyricimonas 0.464185739 0 0 yes butyrate-producing serum_aminoacids Genus 0.00913 0.17 up up no no no no L-Tyrosine+blood CA+stool 0 0.709090909 0 yes serum_aminoacids stool_bileacids 0.00913 0.827 up up no no no no L-Tyrosine+blood Calcium signaling pathway 0.494736842 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no up up L-Tyrosine+blood cAMP signaling pathway 0.519298246 0 0 yes yes serum_aminoacids kegg 0.00913 NA up up no no up up L-Tyrosine+blood Carbon metabolism -0.633333333 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood CDCA+stool 0 0.809090909 0 yes serum_aminoacids stool_bileacids 0.00913 0.663 up up no no no no L-Tyrosine+blood Cell adhesion molecules 0 0 -0.479230769 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood cGMP-PKG signaling pathway 0.461403509 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Chemical carcinogenesis - receptor activation 0 -0.55 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Choline metabolism in cancer 0.489473684 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Choline+blood 0.523308271 0 0.45025641 yes serum_aminoacids serum_choline 0.00913 0.0395 up up no no up no L-Tyrosine+blood Cholinergic synapse 0 -0.582352941 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Coprococcus 0 0.490196078 0 yes butyrate-producing serum_aminoacids Genus 0.00913 0.612 up up no no no no L-Tyrosine+blood Creatinine+blood 0.589473684 0 0 yes serum_aminoacids serum_choline 0.00913 0.437 up up no no no no L-Tyrosine+blood Cysteine+blood 0 0 0.409230769 yes yes serum_aminoacids serum_aminoacids 0.00913 1.81E-07 up up no dn up up L-Tyrosine+blood d18:1-20:1-SM+blood 0 -0.517156863 0 yes serum_aminoacids serum_phospholipids 0.00913 0.0992 up up no no no no L-Tyrosine+blood d18:1-24:1-SM+blood 0 0 -0.421538462 yes serum_aminoacids serum_phospholipids 0.00913 0.0123 up up no no dn dn L-Tyrosine+blood DL-methionine sulfoxide+blood 0 0 0.548034188 yes serum_aminoacids serum_aminoacids 0.00913 0.302 up up no no no no L-Tyrosine+blood Dorea 0 0.531862745 0 yes serum_aminoacids Genus 0.00913 0.00362 up up no up no dn L-Tyrosine+blood ErbB signaling pathway 0.480701754 -0.505882353 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Ethanolamine+blood 0 0 0.671111111 yes serum_aminoacids serum_aminoacids 0.00913 0.122 up up no up no no L-Tyrosine+blood Fc epsilon RI signaling pathway 0.466666667 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Focal adhesion 0 0 -0.402307692 yes serum_aminoacids kegg 0.00913 NA up up no no up up L-Tyrosine+blood Gap junction 0 -0.561764706 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood GCA+stool 0 0.7 0 yes serum_aminoacids stool_bileacids 0.00913 0.0809 up up no no no no L-Tyrosine+blood GCDCA+blood 0 0.526960784 0 yes serum_aminoacids serum_bileacids 0.00913 0.31 up up no no no no L-Tyrosine+blood GCDCA+stool -0.554945055 0.881818182 0 yes yes serum_aminoacids stool_bileacids 0.00913 0.0471 up up no no dn no L-Tyrosine+blood GDCA+stool 0 0.797268583 0 yes serum_aminoacids stool_bileacids 0.00913 0.656 up up no no no no L-Tyrosine+blood Gemmiger 0 0 0.550343273 yes butyrate-producing serum_aminoacids Genus 0.00913 0.595 up up no no no no L-Tyrosine+blood Glioma 0.529824561 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Glutathione metabolism -0.473684211 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Glycolysis / Gluconeogenesis -0.564912281 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood "Growth hormone synthesis, secretion and action" 0 -0.552941176 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Hematopoietic cell lineage 0 0 -0.545384615 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Hepatitis B 0.5 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Hypertrophic cardiomyopathy -0.48245614 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no up up L-Tyrosine+blood Inflammatory bowel disease 0 0 -0.511538462 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Intestinal immune network for IgA production 0 0 -0.592307692 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood iso-heptanoic acid C7+blood -0.636090226 0 0 yes serum_aminoacids serum_mcfa 0.00913 0.00256 up up no up up no L-Tyrosine+blood isocapric acid iso-C6+blood 0.547368421 0 0 yes serum_aminoacids serum_scfa 0.00913 0.0458 up up no no no dn L-Tyrosine+blood L-2-Aminobutyric acid+blood 0.491729323 0 0 yes yes serum_aminoacids serum_aminoacids 0.00913 0.000328 up up no up up no L-Tyrosine+blood L-Arginine+blood 0.57593985 0 0 yes serum_aminoacids serum_aminoacids 0.00913 0.316 up up no no no no L-Tyrosine+blood L-Citrulline+blood 0.445112782 0 0 yes serum_aminoacids serum_aminoacids 0.00913 0.534 up up no no no no L-Tyrosine+blood L-Histidine+blood 0.603007519 0 0.51042735 yes serum_aminoacids serum_aminoacids 0.00913 0.109 up up no no no no L-Tyrosine+blood L-Isoleucine+blood 0 0.644607843 0.673846154 yes yes serum_aminoacids serum_aminoacids 0.00913 5.47E-06 up up no up up no L-Tyrosine+blood L-Leucine+blood 0 0 0.626666667 yes yes serum_aminoacids serum_aminoacids 0.00913 3.22E-05 up up no up up no L-Tyrosine+blood L-Lysine+blood 0.511278195 0.531862745 0.541880342 yes yes serum_aminoacids serum_aminoacids 0.00913 0.0107 up up no no up no L-Tyrosine+blood L-Methionine+blood 0.882706767 0.585784314 0.513162393 yes serum_aminoacids serum_aminoacids 0.00913 0.626 up up no no no no L-Tyrosine+blood L-Phenylalanine+blood 0.846616541 0.754901961 0.76 yes yes serum_aminoacids serum_aminoacids 0.00913 0.0103 up up no up up no L-Tyrosine+blood L-Phenylalanine+stool 0 0 0.509774436 yes serum_aminoacids stool_cometabolism 0.00913 0.398 up up no no no no L-Tyrosine+blood L-Proline+blood 0 0.698529412 0 yes yes serum_aminoacids serum_aminoacids 0.00913 0.00265 up up no up up no L-Tyrosine+blood L-Tryptophan+blood 0.765413534 0.796568627 0.578119658 yes serum_aminoacids serum_aminoacids 0.00913 0.164 up up no no no no L-Tyrosine+blood L-Tryptophan+stool 0 0 0.502255639 yes serum_aminoacids stool_cometabolism 0.00913 0.557 up up no no no no L-Tyrosine+blood L-Tyrosine+stool 0 0 0.517293233 yes serum_aminoacids stool_cometabolism 0.00913 0.44 up up no no no no L-Tyrosine+blood Leishmaniasis -0.48245614 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Long-term potentiation 0.471929825 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no up L-Tyrosine+blood mRNA surveillance pathway 0.589473684 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Non-alcoholic fatty liver disease 0.521052632 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood p53 signaling pathway 0.487719298 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Parabacteroides 0 -0.534313725 0.512224319 yes serum_aminoacids Genus 0.00913 4.19E-05 up up no no up up L-Tyrosine+blood Pathways in cancer 0.728070175 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Phenylacetic acid+stool 0 -0.790909091 0 yes serum_aminoacids stool_cometabolism 0.00913 0.785 up up no no no no L-Tyrosine+blood Phosphatidylinositol signaling system 0.561403509 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Phospholipase D signaling pathway 0.478947368 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no up up L-Tyrosine+blood Platinum drug resistance 0.485964912 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Prevotella 0 0 0.417163783 yes acetate-producing serum_aminoacids Genus 0.00913 0.287 up up no no no no L-Tyrosine+blood Progesterone-mediated oocyte maturation 0.461403509 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Propionic acid+stool 0 -0.654545455 0 yes yes serum_aminoacids stool_scfa 0.00913 0.0436 up up no dn no up L-Tyrosine+blood Proteasome 0 0.602941176 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Renal cell carcinoma 0.478947368 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Rheumatoid arthritis 0 0 -0.473076923 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood RNA degradation 0.528070175 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Roseburia 0 0.62660956 0 yes butyrate-producing serum_aminoacids Genus 0.00913 0.495 up up no no no no L-Tyrosine+blood Ruminococcus 0 0.499080413 0 yes serum_aminoacids Genus 0.00913 0.0679 up up no no no dn L-Tyrosine+blood Ruminococcus 0 0.578431373 0 yes acetate-producing serum_aminoacids Genus 0.00913 0.335 up up no no no no L-Tyrosine+blood Salmonella infection 0 0 -0.452307692 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Serotonergic synapse 0 -0.611764706 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Signaling pathways regulating pluripotency of stem cells 0.540350877 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Sphingolipid signaling pathway 0.577192982 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Spinocerebellar ataxia 0.507017544 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Thyroid hormone signaling pathway 0 0 -0.432307692 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood total_stool_scfa+stool 0 -0.663636364 0 yes serum_aminoacids stool_scfa 0.00913 0.0534 up up no dn no up L-Tyrosine+blood Toxoplasmosis 0 0 -0.475384615 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood UDCA+stool 0 0.672727273 0 yes serum_aminoacids stool_bileacids 0.00913 0.266 up up no no no no L-Tyrosine+blood VEGF signaling pathway 0.561403509 0 0 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+blood Viral myocarditis 0 0 -0.42 yes serum_aminoacids kegg 0.00913 NA up up no no no no L-Tyrosine+stool 5-Hydroxytryptamine+stool 0 0 0.483201581 stool_cometabolism stool_cometabolism 0.44 0.00862 no no no dn dn no L-Tyrosine+stool Allograft rejection 0 0 -0.581027668 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Antigen processing and presentation 0 0 -0.51552795 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Apelin signaling pathway -0.519091847 0 0 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Autoimmune thyroid disease 0 0 -0.581027668 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Butyricicoccus 0 0 -0.507733291 butyrate-producing stool_cometabolism Genus 0.44 0.852 no no no no no no L-Tyrosine+stool CA+stool 0 0 -0.60770751 stool_cometabolism stool_bileacids 0.44 0.827 no no no no no no L-Tyrosine+stool CDCA+stool 0 0 -0.592885375 stool_cometabolism stool_bileacids 0.44 0.663 no no no no no no L-Tyrosine+stool Cell adhesion molecules 0 0 -0.583286279 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Cellular senescence 0 0 -0.600225861 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool DCA+stool -0.649122807 0 0 stool_cometabolism stool_bileacids 0.44 0.195 no no no no no no L-Tyrosine+stool Endocytosis 0 0 -0.565217391 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Epstein-Barr virus infection 0 0 -0.541501976 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Gemmiger -0.702116769 0 0 butyrate-producing stool_cometabolism Genus 0.44 0.595 no no no no no no L-Tyrosine+stool Graft-versus-host disease 0 0 -0.578769057 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Herpes simplex virus 1 infection 0 0 -0.496329757 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Human cytomegalovirus infection 0 0 -0.535855449 stool_cometabolism kegg 0.44 NA no no no no no dn L-Tyrosine+stool Human immunodeficiency virus 1 infection 0 0 -0.524562394 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Human papillomavirus infection 0 0 -0.514398645 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Human T-cell leukemia virus 1 infection 0 0 -0.521174478 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Indole-3-Acetic acid+stool 0 0 0.645256917 stool_cometabolism stool_cometabolism 0.44 0.304 no no no no no no L-Tyrosine+stool Influenza A 0.510835913 0 0 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Isobutyric acid+stool 0 0 0.481225296 stool_cometabolism stool_scfa 0.44 0.408 no no no no no no L-Tyrosine+stool Isovaleric acid+stool 0 0 0.449604743 stool_cometabolism stool_scfa 0.44 0.343 no no no no no no L-Tyrosine+stool Kynurenic acid+stool 0 0.65034965 0.435770751 stool_cometabolism stool_cometabolism 0.44 0.037 no no no dn dn no L-Tyrosine+stool L-Phenylalanine+stool 0.919504644 0.741258741 0.975296443 stool_cometabolism stool_cometabolism 0.44 0.398 no no no no no no L-Tyrosine+stool L-Tryptophan+stool 0.832817337 0.622377622 0.871541502 stool_cometabolism stool_cometabolism 0.44 0.557 no no no no no no L-Tyrosine+stool Methanobrevibacter 0 0 0.444554224 stool_cometabolism Genus 0.44 0.629 no no no no no no L-Tyrosine+stool mTOR signaling pathway -0.494324045 0 0 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Natural killer cell mediated cytotoxicity 0 0 -0.51552795 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Neutrophil extracellular trap formation 0.477812178 0 0 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Pathogenic Escherichia coli infection 0.471620227 0 0 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Phagosome 0 0 -0.462450593 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool RNA transport -0.471620227 0 0 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Succinivibrio 0 0 -0.456470037 stool_cometabolism Genus 0.44 0.138 no no no no no no L-Tyrosine+stool Tuberculosis 0.502579979 0 0 stool_cometabolism kegg 0.44 NA no no no no no dn L-Tyrosine+stool Type I diabetes mellitus 0 0 -0.586674195 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Viral carcinogenesis 0 0 -0.555053642 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool Viral myocarditis 0 0 -0.57312253 stool_cometabolism kegg 0.44 NA no no no no no no L-Tyrosine+stool ¦Ø-MCA+stool 0 -0.725213717 0 stool_cometabolism stool_bileacids 0.44 0.919 no no no no no no L-Tyrosine+urine 16:0/16:0-PC+blood 0.742647059 0 0 urine_cometabolism serum_phospholipids 0.45 0.00079 no no no no up up L-Tyrosine+urine 16:0/18:0-PS+blood -0.492647059 0 0 urine_cometabolism serum_phospholipids 0.45 0.377 no no no no no no L-Tyrosine+urine 16:0/18:1-PC+blood 0.642156863 0 0 urine_cometabolism serum_phospholipids 0.45 6.15E-07 no no no up up up L-Tyrosine+urine 16:0/18:2-PC+blood 0.696078431 0 0 urine_cometabolism serum_phospholipids 0.45 3.24E-06 no no no no up up L-Tyrosine+urine 16:0/20:3-PC+blood 0.68872549 0 0 urine_cometabolism serum_phospholipids 0.45 5.43E-06 no no no no up up L-Tyrosine+urine 16:0/20:4-PC+blood 0.56372549 0 0 urine_cometabolism serum_phospholipids 0.45 0.0262 no no no no up no L-Tyrosine+urine 16:0/22:6-PE+blood -0.583333333 0 0 urine_cometabolism serum_phospholipids 0.45 0.000934 no no no up up no L-Tyrosine+urine 16:1/16:0-PC+blood 0.610294118 0 0 urine_cometabolism serum_phospholipids 0.45 0.0215 no no no no up up L-Tyrosine+urine 16:1/16:1-PC+blood 0.5 0 0 urine_cometabolism serum_phospholipids 0.45 0.0177 no no no no no up L-Tyrosine+urine 16:1/18:2-PG+blood 0.492647059 0 0 urine_cometabolism serum_phospholipids 0.45 1.40E-08 no no no no up up L-Tyrosine+urine 18:0-LPE+blood -0.666666667 0 0 urine_cometabolism serum_phospholipids 0.45 0.491 no no no no no no L-Tyrosine+urine 18:0/16:0-PC+blood 0.639705882 0 0 urine_cometabolism serum_phospholipids 0.45 9.64E-07 no no no up up up L-Tyrosine+urine 18:0/18:1-PE+blood -0.742647059 0 0 urine_cometabolism serum_phospholipids 0.45 0.00716 no no no up up no L-Tyrosine+urine 18:0/18:2-PC+blood 0.605392157 0 0 urine_cometabolism serum_phospholipids 0.45 1.74E-06 no no no no up up L-Tyrosine+urine 18:0/18:2-PI+blood 0 0 0.480519481 urine_cometabolism serum_phospholipids 0.45 0.179 no no no no no no L-Tyrosine+urine 18:0/20:4-PC+blood 0.583333333 0 0 urine_cometabolism serum_phospholipids 0.45 0.454 no no no no no no L-Tyrosine+urine 18:0/22:6-PE+blood -0.556372549 0 0 urine_cometabolism serum_phospholipids 0.45 0.00022 no no no up up no L-Tyrosine+urine 18:1/16:0-PC+blood 0.708333333 0 0 urine_cometabolism serum_phospholipids 0.45 2.43E-05 no no no no up up L-Tyrosine+urine 18:1/18:0-PC+blood 0.669117647 0 0 urine_cometabolism serum_phospholipids 0.45 1.83E-06 no no no no up up L-Tyrosine+urine 18:1/18:1-PC+blood 0.718137255 0 0 urine_cometabolism serum_phospholipids 0.45 1.34E-05 no no no no up up L-Tyrosine+urine 18:1/18:1-PE+blood -0.708333333 0 0 urine_cometabolism serum_phospholipids 0.45 1.03E-05 no no no up up no L-Tyrosine+urine 18:1/20:4-PC+blood 0.531862745 0 0 urine_cometabolism serum_phospholipids 0.45 0.582 no no no no no no L-Tyrosine+urine 18:2/16:0-PC+blood 0.642156863 0 0 urine_cometabolism serum_phospholipids 0.45 8.67E-05 no no no no up up L-Tyrosine+urine 2-hydroxyhippuric acid+urine -0.514285714 -0.571929825 -0.588376068 urine_cometabolism urine_cometabolism 0.45 0.215 no no no no no no L-Tyrosine+urine 2-hydroxyphenylacetic acid+urine 0 0 -0.442735043 urine_cometabolism urine_cometabolism 0.45 0.763 no no no no no no L-Tyrosine+urine 20:1-LPA+blood 0 -0.593406593 0 urine_cometabolism serum_phospholipids 0.45 0.0187 no no no dn dn no L-Tyrosine+urine 20:3/16:0-PC+blood 0.610294118 0 0 urine_cometabolism serum_phospholipids 0.45 0.00405 no no no no up up L-Tyrosine+urine 20:4-LPA+blood 0 -0.554945055 0 urine_cometabolism serum_phospholipids 0.45 0.398 no no no no no no L-Tyrosine+urine 24:1+blood 0.595588235 0 0 urine_cometabolism serum_fattyacid 0.45 0.00582 no no no no dn dn L-Tyrosine+urine "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 0.516581197 urine_cometabolism urine_cometabolism 0.45 0.0125 no no no up up no L-Tyrosine+urine 3-Hydroxy-L-kynurenine+urine 0.628571429 0.733333333 0.61025641 urine_cometabolism urine_cometabolism 0.45 0.401 no no no no no no L-Tyrosine+urine 3-Hydroxytyramine hydrochloride+urine 0 0 0.585641026 urine_cometabolism urine_cometabolism 0.45 0.288 no no no no no no L-Tyrosine+urine 5-Hydroxytryptamine+urine 0 0.547368421 0 urine_cometabolism urine_cometabolism 0.45 0.171 no no no no no no L-Tyrosine+urine Apelin signaling pathway 0 0 0.541538462 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine Apoptosis 0 0 -0.404615385 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine Butyric acid+stool 0.683516484 0 0 yes urine_cometabolism stool_scfa 0.45 0.102 no no no dn no no L-Tyrosine+urine Butyricicoccus 0 0.45606963 0 butyrate-producing urine_cometabolism Genus 0.45 0.852 no no no no no no L-Tyrosine+urine CDCA+blood 0 0.598901099 0 urine_cometabolism serum_bileacids 0.45 0.506 no no no no no no L-Tyrosine+urine Clostridium -0.50366382 0 0 urine_cometabolism Genus 0.45 0.925 no no no no no no L-Tyrosine+urine Coronavirus disease - COVID-19 0 0 0.493846154 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine Cytosolic DNA-sensing pathway 0.494736842 0 0 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine EGFR tyrosine kinase inhibitor resistance 0 0 0.568461538 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine Fc epsilon RI signaling pathway 0 0 -0.427692308 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine Fluid shear stress and atherosclerosis 0 0 -0.463846154 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine Glucagon signaling pathway 0 0 0.56 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine Glycine+blood 0 -0.774725275 0 urine_cometabolism serum_aminoacids 0.45 0.00408 no no no dn no up L-Tyrosine+urine HIF-1 signaling pathway 0 0 0.475384615 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine Insulin signaling pathway 0 0 0.528461538 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine iso-DCA+blood 0.598039216 0 0 urine_cometabolism serum_bileacids 0.45 0.38 no no no no no no L-Tyrosine+urine L-Histidine+blood 0.512254902 0 0 urine_cometabolism serum_aminoacids 0.45 0.109 no no no no no no L-Tyrosine+urine L-Phenylalanine+urine 0.845112782 0.807017544 0.885128205 urine_cometabolism urine_cometabolism 0.45 0.0908 no no no no up no L-Tyrosine+urine L-Tryptophan+urine 0.834586466 0.759649123 0.883760684 urine_cometabolism urine_cometabolism 0.45 0.226 no no no no no no L-Tyrosine+urine Lysosome 0 0 -0.436923077 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine mRNA surveillance pathway 0 0 0.462307692 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine mTOR signaling pathway 0 0 0.509230769 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine MUFA%+blood 0 -0.818681319 0 urine_cometabolism serum_fattyacid 0.45 0.00142 no no no up no dn L-Tyrosine+urine Neuroactive ligand-receptor interaction 0 0 -0.442307692 urine_cometabolism kegg 0.45 NA no no no up up up L-Tyrosine+urine Neurotrophin signaling pathway 0.524561404 0 0 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine "Parathyroid hormone synthesis, secretion and action" 0 0 0.484615385 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine Pertussis 0 0 -0.466923077 urine_cometabolism kegg 0.45 NA no no no no no dn L-Tyrosine+urine Phagosome 0 0 -0.415384615 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine PI3K-Akt signaling pathway 0 0 0.566153846 yes urine_cometabolism kegg 0.45 NA no no no no up up L-Tyrosine+urine Prevotella -0.462539691 0 0 acetate-producing urine_cometabolism Genus 0.45 0.287 no no no no no no L-Tyrosine+urine PUFA/MUFA+blood 0.549019608 0 0 urine_cometabolism serum_fattyacid 0.45 0.00108 no no no dn no up L-Tyrosine+urine PUFA%+blood 0.740196078 -0.730769231 0 urine_cometabolism serum_fattyacid 0.45 0.0013 no no no dn no up L-Tyrosine+urine Pyramidobacter 0 0 0.47249008 urine_cometabolism Genus 0.45 0.45 no no no no no no L-Tyrosine+urine Relaxin signaling pathway 0.514035088 0 0 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine Rheumatoid arthritis 0 0 -0.456153846 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine Ribosome 0 0 0.493846154 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine RNA transport 0 0 0.532307692 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine Serine+blood 0.504901961 0 0 urine_cometabolism serum_aminoacids 0.45 0.942 no no no no no no L-Tyrosine+urine SFA%+blood 0.745098039 -0.791208791 0 urine_cometabolism serum_fattyacid 0.45 0.0236 no no no no up no L-Tyrosine+urine Spliceosome 0 0 0.420769231 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine T cell receptor signaling pathway 0 0 0.415384615 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine TNF signaling pathway 0.542105263 0 0 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine Transcriptional misregulation in cancer 0 0 0.436923077 urine_cometabolism kegg 0.45 NA no no no no no no L-Tyrosine+urine Tuberculosis 0 0 -0.459230769 urine_cometabolism kegg 0.45 NA no no no no no dn L-Tyrosine+urine TUDCA+blood -0.654078197 0 0 yes urine_cometabolism serum_bileacids 0.45 0.0282 no no no no no dn L-Tyrosine+urine TXB2+blood 0 -0.657468598 0 yes urine_cometabolism serum_ARA 0.45 0.0644 no no no dn no no L-Tyrosine+urine UFA%+blood 0.649509804 -0.851648352 0 urine_cometabolism serum_fattyacid 0.45 0.0236 no no no no dn no Lachnobacterium Actinomyces 0 0.436443089 0 Genus Genus 0.867 0.621 no no no no no no Lachnospira Coprococcus 0.540309531 0 0 butyrate-producing butyrate-producing Genus Genus 0.279 0.612 no no no no no no lauric acid C12+blood 12-HEPE+blood 0.515231277 0 0 serum_mcfa serum_ARA 0.015 0.312 no dn dn no no no lauric acid C12+blood 14:0/20:4-PC+blood -0.458646617 0 0 serum_mcfa serum_phospholipids 0.015 0.486 no dn dn no no no lauric acid C12+blood 16:0/14:0-PC+blood 0.488721805 0 0 serum_mcfa serum_phospholipids 0.015 0.0206 no dn dn no up up lauric acid C12+blood 16:0/16:0-PC+blood 0 0 -0.422222222 serum_mcfa serum_phospholipids 0.015 0.00079 no dn dn no up up lauric acid C12+blood 16:0/16:0-PI+blood -0.545864662 0 0 serum_mcfa serum_phospholipids 0.015 0.358 no dn dn no no no lauric acid C12+blood 16:0/16:1-PC+blood 0 0 -0.411965812 serum_mcfa serum_phospholipids 0.015 0.00283 no dn dn up up no lauric acid C12+blood 16:0/16:1-PI+blood -0.657142857 0 -0.461880342 serum_mcfa serum_phospholipids 0.015 0.262 no dn dn no no no lauric acid C12+blood 16:0/18:0-PS+blood -0.577443609 0 0 serum_mcfa serum_phospholipids 0.015 0.377 no dn dn no no no lauric acid C12+blood 16:0/18:1-PC+blood 0.488721805 0 0 serum_mcfa serum_phospholipids 0.015 6.15E-07 no dn dn up up up lauric acid C12+blood 16:0/18:1-PE+blood -0.583458647 0 0 serum_mcfa serum_phospholipids 0.015 0.000107 no dn dn up up no lauric acid C12+blood 16:0/18:2-PC+blood 0.527819549 0 0 serum_mcfa serum_phospholipids 0.015 3.24E-06 no dn dn no up up lauric acid C12+blood 16:0/18:2-PI+blood -0.473684211 0 0 serum_mcfa serum_phospholipids 0.015 0.269 no dn dn no no no lauric acid C12+blood 16:0/18:3-PC+blood -0.508270677 0 -0.492649573 serum_mcfa serum_phospholipids 0.015 0.00216 no dn dn no up up lauric acid C12+blood 16:0/20:3-PC+blood 0.535338346 0.544117647 0 serum_mcfa serum_phospholipids 0.015 5.43E-06 no dn dn no up up lauric acid C12+blood 16:0/20:4-PC+blood 0.621052632 0 0 serum_mcfa serum_phospholipids 0.015 0.0262 no dn dn no up no lauric acid C12+blood 18:0/16:0-PC+blood 0.481203008 0 0 serum_mcfa serum_phospholipids 0.015 9.64E-07 no dn dn up up up lauric acid C12+blood 18:0/18:0-PC+blood 0 0 -0.456410256 serum_mcfa serum_phospholipids 0.015 0.426 no dn dn no no no lauric acid C12+blood 18:0/18:0-PE+blood -0.44962406 0 0 serum_mcfa serum_phospholipids 0.015 0.00896 no dn dn up up no lauric acid C12+blood 18:0/18:0-PS+blood -0.479699248 0 0 serum_mcfa serum_phospholipids 0.015 0.00617 no dn dn no up no lauric acid C12+blood 18:0/18:1-PC+blood 0 0 -0.45982906 serum_mcfa serum_phospholipids 0.015 0.393 no dn dn no no no lauric acid C12+blood 18:0/18:1-PE+blood -0.514285714 0 0 serum_mcfa serum_phospholipids 0.015 0.00716 no dn dn up up no lauric acid C12+blood 18:0/18:2-PC+blood 0.532330827 0 0 serum_mcfa serum_phospholipids 0.015 1.74E-06 no dn dn no up up lauric acid C12+blood 18:0/20:3-PC+blood 0 0 -0.448888889 serum_mcfa serum_phospholipids 0.015 0.0682 no dn dn no up no lauric acid C12+blood 18:0/20:4-PC+blood 0.606015038 0 0 serum_mcfa serum_phospholipids 0.015 0.454 no dn dn no no no lauric acid C12+blood 18:0/22:6-PC+blood 0 -0.487745098 0 serum_mcfa serum_phospholipids 0.015 0.0775 no dn dn no no up lauric acid C12+blood 18:0/22:6-PE+blood -0.458646617 -0.524509804 0 serum_mcfa serum_phospholipids 0.015 0.00022 no dn dn up up no lauric acid C12+blood 18:0+blood 0 0 -0.556923077 serum_mcfa serum_fattyacid 0.015 0.344 no dn dn no no no lauric acid C12+blood 18:1-LPC+blood 0.609022556 0 0 serum_mcfa serum_phospholipids 0.015 0.179 no dn dn no no no lauric acid C12+blood 18:1/16:0-PC+blood 0.554887218 0 0 serum_mcfa serum_phospholipids 0.015 2.43E-05 no dn dn no up up lauric acid C12+blood 18:1/16:0-PE+blood -0.587969925 0 0 serum_mcfa serum_phospholipids 0.015 0.000182 no dn dn up up no lauric acid C12+blood 18:1/16:1-PE+blood -0.645112782 0 0 serum_mcfa serum_phospholipids 0.015 0.000184 no dn dn up up no lauric acid C12+blood 18:1/18:0-PC+blood 0.514285714 0 0 serum_mcfa serum_phospholipids 0.015 1.83E-06 no dn dn no up up lauric acid C12+blood 18:1/18:0-PE+blood -0.553383459 0 0 serum_mcfa serum_phospholipids 0.015 1.39E-06 no dn dn up up no lauric acid C12+blood 18:1/18:1-PC+blood 0.490225564 0.531862745 0 serum_mcfa serum_phospholipids 0.015 1.34E-05 no dn dn no up up lauric acid C12+blood 18:1/18:1-PE+blood -0.586466165 0 0 serum_mcfa serum_phospholipids 0.015 1.03E-05 no dn dn up up no lauric acid C12+blood 18:1/18:1-PI+blood 0.539849624 0 0 serum_mcfa serum_phospholipids 0.015 0.111 no dn dn dn no no lauric acid C12+blood 18:1/20:3-PC+blood 0 0.551470588 0 serum_mcfa serum_phospholipids 0.015 0.00872 no dn dn no up up lauric acid C12+blood 18:1/20:4-PI+blood 0 0 -0.501538462 serum_mcfa serum_phospholipids 0.015 0.192 no dn dn no no no lauric acid C12+blood 18:2-LPC+blood 0.618045113 0 0 serum_mcfa serum_phospholipids 0.015 0.00743 no dn dn dn no up lauric acid C12+blood 18:2-LPE+blood 0 0.595588235 0 serum_mcfa serum_phospholipids 0.015 0.112 no dn dn no no no lauric acid C12+blood 18:2/16:0-PC+blood 0.536842105 0 0 serum_mcfa serum_phospholipids 0.015 8.67E-05 no dn dn no up up lauric acid C12+blood 18:2/18:1-PC+blood 0.461654135 0 0 serum_mcfa serum_phospholipids 0.015 2.30E-05 no dn dn dn up up lauric acid C12+blood 18:2/18:2-PS+blood -0.530827068 0 0 serum_mcfa serum_phospholipids 0.015 0.00674 no dn dn up up no lauric acid C12+blood 18:3/16:0-PE+blood -0.839097744 0 0 serum_mcfa serum_phospholipids 0.015 0.00149 no dn dn up up no lauric acid C12+blood 18:3n6+blood -0.461654135 0 -0.507692308 serum_mcfa serum_fattyacid 0.015 0.0463 no dn dn up no dn lauric acid C12+blood 2-methyl-butyric acid m-C4+blood 0.496240602 0 0 serum_mcfa serum_scfa 0.015 0.262 no dn dn no no no lauric acid C12+blood 20:2/18:0-PC+blood 0 0 -0.450940171 serum_mcfa serum_phospholipids 0.015 0.0427 no dn dn no up no lauric acid C12+blood 20:2/18:1-PE+blood -0.634586466 0 0 serum_mcfa serum_phospholipids 0.015 0.00208 no dn dn up up no lauric acid C12+blood 20:2+blood 0 0.598039216 0 serum_mcfa serum_fattyacid 0.015 0.478 no dn dn no no no lauric acid C12+blood 20:3-LPE+blood 0 0.571078431 0 serum_mcfa serum_phospholipids 0.015 0.084 no dn dn no up no lauric acid C12+blood 20:3/16:0-PC+blood 0.637593985 0 0 serum_mcfa serum_phospholipids 0.015 0.00405 no dn dn no up up lauric acid C12+blood 20:4/16:0-PE+blood -0.482706767 0 0 serum_mcfa serum_phospholipids 0.015 0.00529 no dn dn no up up lauric acid C12+blood 20:5-LPC+blood 0 -0.629901961 0 serum_mcfa serum_phospholipids 0.015 0.558 no dn dn no no no lauric acid C12+blood 22:1-LPA+blood 0 0.49754902 0 serum_mcfa serum_phospholipids 0.015 0.00373 no dn dn no up up lauric acid C12+blood 22:2-LPA+blood 0 0.595588235 0 serum_mcfa serum_phospholipids 0.015 0.0443 no dn dn dn no no lauric acid C12+blood 22:6-LPC+blood 0 -0.556372549 0 serum_mcfa serum_phospholipids 0.015 0.127 no dn dn no no up lauric acid C12+blood capric acid C6+blood 0 0 0.404444444 serum_mcfa serum_scfa 0.015 0.433 no dn dn no no no lauric acid C12+blood Creatinine+blood 0.673684211 0 0 serum_mcfa serum_choline 0.015 0.437 no dn dn no no no lauric acid C12+blood Cysteine+blood 0.544360902 0.585784314 0 yes serum_mcfa serum_aminoacids 0.015 1.81E-07 no dn dn dn up up lauric acid C12+blood d18:1-14:0-SM+blood -0.50075188 0 0 serum_mcfa serum_phospholipids 0.015 0.94 no dn dn no no no lauric acid C12+blood d18:1-14:1-SM+blood -0.553383459 0 0 serum_mcfa serum_phospholipids 0.015 0.0952 no dn dn no dn no lauric acid C12+blood decanoic acid C10+blood 0.855639098 0.620098039 0.556923077 serum_mcfa serum_mcfa 0.015 6.64E-11 no dn dn dn dn no lauric acid C12+blood HDCA+blood 0.457488141 0 0.565895059 serum_mcfa serum_bileacids 0.015 0.483 no dn dn no no no lauric acid C12+blood heptanoic acid C7+blood 0.464661654 0.806372549 0 serum_mcfa serum_mcfa 0.015 8.27E-11 no dn dn dn dn no lauric acid C12+blood L-Alanine+blood 0 0 -0.540512821 yes serum_mcfa serum_aminoacids 0.015 0.00138 no dn dn up up no lauric acid C12+blood L-Arginine+blood 0.496240602 0 0 serum_mcfa serum_aminoacids 0.015 0.316 no dn dn no no no lauric acid C12+blood L-Lysine+blood 0.54887218 0.492647059 0 yes serum_mcfa serum_aminoacids 0.015 0.0107 no dn dn no up no lauric acid C12+blood L-Methionine+blood 0.604511278 0 0 serum_mcfa serum_aminoacids 0.015 0.626 no dn dn no no no lauric acid C12+blood L-Phenylalanine+blood 0.47518797 0 0 yes serum_mcfa serum_aminoacids 0.015 0.0103 no dn dn up up no lauric acid C12+blood L-Tryptophan+blood 0.612030075 0 0 serum_mcfa serum_aminoacids 0.015 0.164 no dn dn no no no LCA+blood 12-ketoDCA+blood 0.472304606 0.832322049 0.693890105 serum_bileacids serum_bileacids 0.884 0.517 no no no no no no LCA+blood "12,13-EPOME+blood" 0 0 0.462194374 serum_bileacids serum_ARA 0.884 0.901 no no no no no no LCA+blood 14:0/18:2-PC+blood -0.450686011 0 0 serum_bileacids serum_phospholipids 0.884 0.102 no no no no up no LCA+blood 16:0/16:0-PI+blood -0.452292735 0 0 serum_bileacids serum_phospholipids 0.884 0.358 no no no no no no LCA+blood 16:0/18:2-PI+blood -0.517365047 0 0 serum_bileacids serum_phospholipids 0.884 0.269 no no no no no no LCA+blood 18:0-LPC+blood 0 0.516219364 0 serum_bileacids serum_phospholipids 0.884 0.554 no no no no no no LCA+blood 18:0/20:3-PC+blood -0.582437358 0 0 serum_bileacids serum_phospholipids 0.884 0.0682 no no no no up no LCA+blood 18:0/22:6-PC+blood -0.529415475 0 0 serum_bileacids serum_phospholipids 0.884 0.0775 no no no no no up LCA+blood 18:0/22:6-PI+blood -0.695711382 0 0 serum_bileacids serum_phospholipids 0.884 0.425 no no no no no no LCA+blood 18:1-LPE+blood 0 0 -0.47474693 serum_bileacids serum_phospholipids 0.884 0.117 no no no no no no LCA+blood 18:1/16:0-PE+blood 0 -0.504747823 0 serum_bileacids serum_phospholipids 0.884 0.000182 no no no up up no LCA+blood 18:3n3+blood -0.487640657 0 0 serum_bileacids serum_fattyacid 0.884 0.291 no no no no no no LCA+blood 20:0-LPC+blood 0 0.510483593 0 serum_bileacids serum_phospholipids 0.884 0.199 no no no no no no LCA+blood 20:1-LPE+blood 0 0 -0.444152928 serum_bileacids serum_phospholipids 0.884 0.465 no no no no no no LCA+blood 20:1/20:4-PC+blood -0.499691085 0 0 serum_bileacids serum_phospholipids 0.884 0.0419 no no no no no up LCA+blood 20:2/18:0-PC+blood -0.550302883 0 0 serum_bileacids serum_phospholipids 0.884 0.0427 no no no no up no LCA+blood 20:2/18:1-PE+blood -0.465146525 0 0 serum_bileacids serum_phospholipids 0.884 0.00208 no no no up up no LCA+blood 20:3-LPE+blood 0 0 -0.508220368 serum_bileacids serum_phospholipids 0.884 0.084 no no no no up no LCA+blood 20:3/16:0-PC+blood 0.526202027 0 0 serum_bileacids serum_phospholipids 0.884 0.00405 no no no no up up LCA+blood 20:3n6+blood -0.474786867 0 0 serum_bileacids serum_fattyacid 0.884 0.0884 no no no up no no LCA+blood 20:5/18:0-PC+blood -0.447472564 0 0 serum_bileacids serum_phospholipids 0.884 3.97E-06 no no no no up up LCA+blood 22:6-LPC+blood -0.560746588 0 0 serum_bileacids serum_phospholipids 0.884 0.127 no no no no no up LCA+blood 22:6n3+blood -0.613768471 0 0 serum_bileacids serum_fattyacid 0.884 0.792 no no no no no no LCA+blood 24:1+blood 0 -0.636670549 0 serum_bileacids serum_fattyacid 0.884 0.00582 no no no no dn dn LCA+blood 3-(3-Hydroxyphenyl)propanoic acid+stool -0.717800578 0 -0.460356566 serum_bileacids stool_cometabolism 0.884 0.33 no no no no no no LCA+blood 4-hydroxybenzoic acid+stool 0 0 -0.463509693 serum_bileacids stool_cometabolism 0.884 0.0536 no no no no dn no LCA+blood ACA+blood 0.642060086 0 0 serum_bileacids serum_bileacids 0.884 0.338 no no no no no no LCA+blood acetic acid C2+blood -0.476393591 0 0 serum_bileacids serum_scfa 0.884 0.000193 no no no up dn no LCA+blood Adipocytokine signaling pathway 0.500773396 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood AGE-RAGE signaling pathway in diabetic complications -0.51375641 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Akkermansia -0.473819742 0 0 acetate-producing serum_bileacids Genus 0.884 0.23 no no no no no no LCA+blood Alistipes 0.551980231 0 0 serum_bileacids Genus 0.884 0.0114 no no no no up no LCA+blood AMPK signaling pathway 0.489645098 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Blautia -0.497281 0 -0.41245193 acetate-producing serum_bileacids Genus 0.884 1.36E-05 no no no up dn dn LCA+blood CA+blood 0.586674764 0 0 serum_bileacids serum_bileacids 0.884 0.606 no no no no no no LCA+blood CA+stool -0.570849278 0 0 serum_bileacids stool_bileacids 0.884 0.827 no no no no no no LCA+blood CDCA+stool -0.553893359 0 -0.472969074 serum_bileacids stool_bileacids 0.884 0.663 no no no no no no LCA+blood Clostridium -0.544884232 -0.484381641 0 serum_bileacids Genus 0.884 0.925 no no no no no no LCA+blood Clostridium -0.494593535 -0.484381641 0 serum_bileacids Genus 0.884 0.925 no no no no no no LCA+blood Coronavirus disease - COVID-19 0.471097935 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Cytokine-cytokine receptor interaction -0.472952651 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood d18:0-24:1-SM+blood 0 0.559237644 0 serum_bileacids serum_phospholipids 0.884 0.0609 no no no no dn dn LCA+blood d18:1-24:1-SM+blood 0 0.504747823 0 serum_bileacids serum_phospholipids 0.884 0.0123 no no no no dn dn LCA+blood DPA+blood -0.45871963 0 0 serum_bileacids serum_ARA 0.884 0.519 no no no no no no LCA+blood Endocrine resistance 0 0.50356808 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Ethanolamine+blood 0.449882649 0 0 serum_bileacids serum_aminoacids 0.884 0.122 no no no up no no LCA+blood Faecalibacterium 0 0 -0.501287442 butyrate-producing serum_bileacids Genus 0.884 0.0039 no no no no dn dn LCA+blood Fc gamma R-mediated phagocytosis -0.485935665 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood FoxO signaling pathway -0.582380912 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Gemmiger 0.504511257 0 0 butyrate-producing serum_bileacids Genus 0.884 0.595 no no no no no no LCA+blood GLCA+blood 0.551140312 0.568342145 0.546695481 serum_bileacids serum_bileacids 0.884 0.319 no no no no no no LCA+blood Glycine+blood 0.520578494 0 0 serum_bileacids serum_aminoacids 0.884 0.00408 no no no dn no up LCA+blood GUDCA+blood 0 0 -0.519018251 serum_bileacids serum_bileacids 0.884 0.0766 no no no no no dn LCA+blood HCA+stool -0.661280847 0 -0.717336429 serum_bileacids stool_bileacids 0.884 0.155 no no no no no no LCA+blood HDCA+blood 0 0.709282373 0 serum_bileacids serum_bileacids 0.884 0.483 no no no no no no LCA+blood HDCA+stool 0.661280847 0 0.472969074 serum_bileacids stool_bileacids 0.884 0.176 no no no no no no LCA+blood heptanoic acid C7+blood 0 0.556369759 0 serum_bileacids serum_mcfa 0.884 8.27E-11 no no no dn dn no LCA+blood Hypotaurine+blood 0.58725753 0 0 serum_bileacids serum_aminoacids 0.884 0.933 no no no no no no LCA+blood iso-LCA+blood 0.838197425 0.687919463 0.707054682 serum_bileacids serum_bileacids 0.884 0.507 no no no no no no LCA+blood iso-LCA+stool 0.645211818 0 0.663733268 serum_bileacids stool_bileacids 0.884 0.72 no no no no no no LCA+blood L-Glutamine+blood 0.486837295 0 0 serum_bileacids serum_aminoacids 0.884 0.639 no no no no no no LCA+blood L-Proline+blood 0.56154995 0 0 yes serum_bileacids serum_aminoacids 0.884 0.00265 no no no up up no LCA+blood L-Threonine+blood 0 0 -0.406000407 serum_bileacids serum_aminoacids 0.884 0.0538 no no no dn no up LCA+blood LCA+stool 0 0 0.458780002 serum_bileacids stool_bileacids 0.884 0.314 no no no no no no LCA+blood Lipid and atherosclerosis -0.491499814 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Longevity regulating pathway - multiple species -0.493354531 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Mitophagy - animal 0.52859414 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood nutriCA+stool -0.672584793 0 -0.618012924 serum_bileacids stool_bileacids 0.884 0.481 no no no no no no LCA+blood Olfactory transduction -0.498918679 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Parkinson disease 0.485935665 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Pathways of neurodegeneration - multiple diseases 0.497063963 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Peroxisome -0.539722438 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Pertussis -0.471097935 0 0 serum_bileacids kegg 0.884 NA no no no no no dn LCA+blood Prevotella 0.556660799 0 0 serum_bileacids Genus 0.884 0.367 no no no no no no LCA+blood Prolactin signaling pathway 0 0 0.424510822 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Proteoglycans in cancer 0.510046977 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Regulation of actin cytoskeleton 0 -0.505257906 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Ribosome 0.471097935 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Shigellosis 0.576816763 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood Ubiquitin mediated proteolysis 0.530448856 0 0 serum_bileacids kegg 0.884 NA no no no no no no LCA+blood UDCA+stool 0 0 -0.704723921 serum_bileacids stool_bileacids 0.884 0.266 no no no no no no LCA+stool 12-ketoDCA+stool 0.589267286 0.71803963 0.633399209 stool_bileacids stool_bileacids 0.314 0.505 no no no no no no LCA+stool 4-hydroxybenzoic acid+stool 0 -0.678321678 0 stool_bileacids stool_cometabolism 0.314 0.0536 no no no no dn no LCA+stool AGE-RAGE signaling pathway in diabetic complications 0 0 0.569734613 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Akkermansia 0 0 0.424794763 acetate-producing stool_bileacids Genus 0.314 0.23 no no no no no no LCA+stool Aldosterone synthesis and secretion 0 0.709090909 0 stool_bileacids kegg 0.314 NA no no no no up up LCA+stool Allograft rejection 0 -0.718181818 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Amphetamine addiction 0.566563467 0 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Antigen processing and presentation 0 -0.736363636 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Apoptosis -0.488132095 0 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Autoimmune thyroid disease 0 -0.718181818 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Autophagy - animal 0 0 0.440993789 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Axon guidance 0 0 0.460191982 stool_bileacids kegg 0.314 NA no no no no up up LCA+stool Bacterial invasion of epithelial cells 0 -0.672727273 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Biosynthesis of amino acids -0.473684211 -0.654545455 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool CA+stool -0.628482972 -0.65034965 -0.444664032 stool_bileacids stool_bileacids 0.314 0.827 no no no no no no LCA+stool Carbon metabolism 0 -0.854545455 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool CDCA+stool -0.667698658 -0.594405594 -0.480237154 stool_bileacids stool_bileacids 0.314 0.663 no no no no no no LCA+stool Cell adhesion molecules 0 -0.745454545 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Cellular senescence 0 -0.654545455 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Central carbon metabolism in cancer 0 0 0.447769622 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Chemical carcinogenesis - receptor activation 0 0.818181818 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Clostridium 0 -0.64942555 0 stool_bileacids Genus 0.314 0.925 no no no no no no LCA+stool Cocaine addiction 0 0.736363636 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Collinsella 0 0 -0.424891508 stool_bileacids Genus 0.314 0.128 no no no no no no LCA+stool Coprococcus 0 0 0.59486166 butyrate-producing stool_bileacids Genus 0.314 0.612 no no no no no no LCA+stool Cortisol synthesis and secretion 0 0.790909091 0 stool_bileacids kegg 0.314 NA no no no no no up LCA+stool Cushing syndrome 0 0.845454545 0 stool_bileacids kegg 0.314 NA no no no no no up LCA+stool DCA+stool 0.735810114 0.874125874 0.838932806 stool_bileacids stool_bileacids 0.314 0.195 no no no no no no LCA+stool Dorea -0.651186791 0 0 stool_bileacids Genus 0.314 0.00362 no no no up no dn LCA+stool Endocrine resistance 0.504643963 0.790909091 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Endocytosis -0.51496388 -0.781818182 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Epstein-Barr virus infection 0 -0.627272727 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Fc gamma R-mediated phagocytosis -0.469556244 -0.645454545 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Fluid shear stress and atherosclerosis 0 -0.754545455 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool FoxO signaling pathway -0.475748194 0 0.704121965 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool GABAergic synapse -0.490196078 0 0 stool_bileacids kegg 0.314 NA no no no no up up LCA+stool Gastric cancer 0 0 0.517786561 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool GCA+stool 0 -0.818181818 0 stool_bileacids stool_bileacids 0.314 0.0809 no no no no no no LCA+stool GLCA+stool -0.643303768 0 0 stool_bileacids stool_bileacids 0.314 0.617 no no no no no no LCA+stool GnRH signaling pathway 0 0.781818182 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Graft-versus-host disease 0 -0.718181818 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool "Growth hormone synthesis, secretion and action" 0 0.7 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool HDCA+stool 0.498452012 0.685314685 0.589920949 stool_bileacids stool_bileacids 0.314 0.176 no no no no no no LCA+stool Herpes simplex virus 1 infection 0 -0.663636364 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Human cytomegalovirus infection 0 -0.663636364 0 stool_bileacids kegg 0.314 NA no no no no no dn LCA+stool Human immunodeficiency virus 1 infection 0 -0.627272727 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Human T-cell leukemia virus 1 infection 0 -0.690909091 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Insulin secretion 0 0.781818182 0 yes stool_bileacids kegg 0.314 NA no no no no up up LCA+stool iso-DCA+stool 0.636738906 0 0 stool_bileacids stool_bileacids 0.314 0.155 no no no no no no LCA+stool iso-LCA+stool 0.747547854 0.972027972 0.833992095 stool_bileacids stool_bileacids 0.314 0.72 no no no no no no LCA+stool JAK-STAT signaling pathway 0 0 0.426312818 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Leishmaniasis 0 -0.7 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Leukocyte transendothelial migration 0 -0.790909091 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Lysosome 0 -0.618181818 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool MAPK signaling pathway 0 0 0.469226426 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool MicroRNAs in cancer 0 0 0.481648786 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Morphine addiction 0 0.790909091 0 stool_bileacids kegg 0.314 NA no no no no up up LCA+stool mRNA surveillance pathway 0.488132095 0 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Natural killer cell mediated cytotoxicity 0 -0.736363636 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Neuroactive ligand-receptor interaction 0 -0.772727273 0 stool_bileacids kegg 0.314 NA no no no up up up LCA+stool Neutrophil extracellular trap formation -0.554179567 -0.672727273 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool NOD-like receptor signaling pathway 0 0 0.532467532 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Odoribacter 0 -0.874125874 0 butyrate-producing stool_bileacids Genus 0.314 0.798 no no no no no no LCA+stool Olfactory transduction -0.510835913 0 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Oscillospira 0.531475748 0 0 LPS-producing stool_bileacids Genus 0.314 0.62 no no no no no no LCA+stool Osteoclast differentiation -0.479876161 0 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool p53 signaling pathway 0 0.827272727 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Pancreatic cancer 0 0 0.730095991 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Pancreatic secretion 0 0.609090909 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Pathogenic Escherichia coli infection 0 -0.818181818 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Pathways in cancer 0 0.809090909 0.509881423 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Peroxisome -0.502579979 0 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Pertussis 0 -0.672727273 0 stool_bileacids kegg 0.314 NA no no no no no dn LCA+stool Phagosome 0 -0.8 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Platinum drug resistance 0 0 0.532467532 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Proteasome 0 -0.609090909 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Regulation of lipolysis in adipocytes 0 0.636363636 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Renal cell carcinoma 0 0 0.480519481 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Rheumatoid arthritis 0 -0.609090909 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool RNA degradation 0.547987616 0 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Ruminococcus 0.616099071 0 0 acetate-producing stool_bileacids Genus 0.314 0.335 no no no no no no LCA+stool Salmonella infection 0 -0.863636364 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Serotonergic synapse 0 0.636363636 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Signaling pathways regulating pluripotency of stem cells 0 0.663636364 0.532467532 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Staphylococcus aureus infection 0 -0.645454545 0 stool_bileacids kegg 0.314 NA no no no up no no LCA+stool T cell receptor signaling pathway 0 0 0.495200452 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Thyroid hormone synthesis 0 0.636363636 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Tight junction 0 -0.709090909 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Tuberculosis 0 -0.7 0 stool_bileacids kegg 0.314 NA no no no no no dn LCA+stool Type I diabetes mellitus 0 -0.718181818 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Viral carcinogenesis -0.488132095 0 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool Viral myocarditis 0 -0.754545455 0 stool_bileacids kegg 0.314 NA no no no no no no LCA+stool ¦Ø-MCA+stool -0.684300765 0 0 stool_bileacids stool_bileacids 0.314 0.919 no no no no no no Legionellosis ABC transporters 0.560869565 -0.450592885 -0.424453024 kegg kegg NA NA no no no no up up Legionellosis Adrenergic signaling in cardiomyocytes -0.422608696 0 0 kegg kegg NA NA no no no no no up Legionellosis AGE-RAGE signaling pathway in diabetic complications 0 -0.441699605 0 kegg kegg NA NA no no no no no no Legionellosis Aldosterone synthesis and secretion -0.51826087 0 0 kegg kegg NA NA no no no no up up Legionellosis alpha-Linolenic acid metabolism 0.548695652 -0.513833992 0 kegg kegg NA NA no no no no no no Legionellosis Amino sugar and nucleotide sugar metabolism 0.595652174 -0.510869565 0 kegg kegg NA NA no no no no no no Legionellosis Aminoacyl-tRNA biosynthesis 0.540869565 0 0 kegg kegg NA NA no no no no no no Legionellosis Amphetamine addiction -0.46 0 0 kegg kegg NA NA no no no no no no Legionellosis Apelin signaling pathway 0 0.722332016 0.485714286 kegg kegg NA NA no no no no no no Legionellosis Bacteroides 0 0.491106719 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Legionellosis Base excision repair 0.410434783 0 0 kegg kegg NA NA no no no no no no Legionellosis beta-Alanine metabolism 0.428695652 0 0 kegg kegg NA NA no no no no no no Legionellosis Bile secretion -0.525217391 0 0 kegg kegg NA NA no no no no no no Legionellosis Biosynthesis of amino acids 0.466956522 0 0 kegg kegg NA NA no no no no no no Legionellosis Butanoate metabolism 0.511304348 0 0.515315315 kegg kegg NA NA no no no no no no Legionellosis Calcium signaling pathway -0.552173913 0 0 kegg kegg NA NA no no no no up up Legionellosis cAMP signaling pathway -0.448695652 0 0 yes kegg kegg NA NA no no no no up up Legionellosis Carbohydrate digestion and absorption 0 0 -0.401801802 kegg kegg NA NA no no no no no no Legionellosis Carbon metabolism 0.499130435 0 0 kegg kegg NA NA no no no no no no Legionellosis Cardiac muscle contraction -0.407826087 0 0 kegg kegg NA NA no no no no no up Legionellosis Cholinergic synapse 0 0 -0.502702703 kegg kegg NA NA no no no no no no Legionellosis Cocaine addiction -0.447826087 0 0 kegg kegg NA NA no no no no no no Legionellosis Complement and coagulation cascades 0.437391304 0 0 kegg kegg NA NA no no no no no no Legionellosis Cysteine and methionine metabolism 0.597391304 0.533596838 0.46023166 kegg kegg NA NA no no no no no no Legionellosis Dopaminergic synapse -0.420869565 0 0 kegg kegg NA NA no no no no up no Legionellosis Dorea 0.476521739 0 0 kegg Genus NA 0.00362 no no no up no dn Legionellosis Drug metabolism - cytochrome P450 0.528695652 0 0 kegg kegg NA NA no no no no no no Legionellosis Drug metabolism - other enzymes 0.472173913 0 0 kegg kegg NA NA no no no no no no Legionellosis EGFR tyrosine kinase inhibitor resistance 0 0.781620553 0.552638353 kegg kegg NA NA no no no no no no Legionellosis Endocrine and other factor-regulated calcium reabsorption -0.570434783 0 0 kegg kegg NA NA no no no no no no Legionellosis Endocrine resistance -0.587826087 0 0 kegg kegg NA NA no no no no no no Legionellosis Ether lipid metabolism -0.43826087 0 0 kegg kegg NA NA no no no no no no Legionellosis Fanconi anemia pathway 0.448695652 0 0 kegg kegg NA NA no no no no no no Legionellosis Fatty acid elongation 0 0.416007905 0.436036036 kegg kegg NA NA no no no no no no Legionellosis Fc epsilon RI signaling pathway -0.586086957 0 -0.536164736 kegg kegg NA NA no no no no no no Legionellosis Folate biosynthesis 0 0 -0.443243243 kegg kegg NA NA no no no no no no Legionellosis Fructose and mannose metabolism 0.510434783 -0.504940711 0 kegg kegg NA NA no no no no no no Legionellosis Galactose metabolism 0 -0.427865613 0 kegg kegg NA NA no no no no no no Legionellosis Gastric acid secretion -0.432173913 0 0 kegg kegg NA NA no no no no no no Legionellosis Glutamatergic synapse -0.505217391 -0.43083004 0 kegg kegg NA NA no no no no up up Legionellosis Glycerolipid metabolism 0 -0.51284585 -0.414157014 kegg kegg NA NA no no no no no up Legionellosis Glycerophospholipid metabolism 0 -0.5256917 0 kegg kegg NA NA no no no no no up Legionellosis Glycolysis / Gluconeogenesis 0.655652174 0.613636364 0.475933076 kegg kegg NA NA no no no no no no Legionellosis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.433794466 -0.4002574 kegg kegg NA NA no no no no no no Legionellosis Glycosaminoglycan biosynthesis - keratan sulfate -0.540869565 0 0 kegg kegg NA NA no no no no no no Legionellosis Glycosaminoglycan degradation 0 0 -0.401801802 kegg kegg NA NA no no no no no up Legionellosis Glycosphingolipid biosynthesis - lacto and neolacto series -0.513913043 0 0 kegg kegg NA NA no no no no no no Legionellosis GnRH secretion 0 0 -0.501673102 kegg kegg NA NA no no no no up up Legionellosis GnRH signaling pathway -0.480869565 0 0 kegg kegg NA NA no no no no no no Legionellosis "Growth hormone synthesis, secretion and action" -0.552173913 -0.447628458 0 kegg kegg NA NA no no no no no no Legionellosis Hedgehog signaling pathway -0.58 0 0 kegg kegg NA NA no no no no no no Legionellosis HIF-1 signaling pathway 0.437391304 0.81027668 0.617760618 kegg kegg NA NA no no no no no no Legionellosis Hippo signaling pathway - multiple species 0 -0.592885375 -0.489060489 kegg kegg NA NA no no no no no no Legionellosis Homologous recombination 0.540869565 0 0 kegg kegg NA NA no no no no no no Legionellosis Huntington disease -0.431304348 0 0 kegg kegg NA NA no no no no no no Legionellosis Inflammatory mediator regulation of TRP channels -0.46 0 0 kegg kegg NA NA no no no no no no Legionellosis Insulin secretion -0.495652174 0 0 yes kegg kegg NA NA no no no no up up Legionellosis Insulin signaling pathway 0 0.738142292 0.474646075 kegg kegg NA NA no no no no no no Legionellosis JAK-STAT signaling pathway 0 -0.471343874 0 kegg kegg NA NA no no no no no no Legionellosis Linoleic acid metabolism 0.446956522 0 0 kegg kegg NA NA no no no no no no Legionellosis Long-term depression -0.66173913 0 0 kegg kegg NA NA no no no no no no Legionellosis Long-term potentiation 0 0.451581028 0 kegg kegg NA NA no no no no no up Legionellosis Longevity regulating pathway - multiple species 0 0 0.451994852 kegg kegg NA NA no no no no no no Legionellosis Maturity onset diabetes of the young -0.579130435 -0.415019763 -0.493951094 kegg kegg NA NA no no no no up no Legionellosis Melanogenesis -0.466086957 0 0 kegg kegg NA NA no no no no no no Legionellosis Metabolism of xenobiotics by cytochrome P450 0.499130435 0 0 kegg kegg NA NA no no no no no no Legionellosis Mismatch repair 0.493913043 0 0 kegg kegg NA NA no no no no no no Legionellosis Morphine addiction -0.527826087 0 0 kegg kegg NA NA no no no no up up Legionellosis mTOR signaling pathway 0 0.76284585 0.578893179 kegg kegg NA NA no no no no no no Legionellosis Mucin type O-glycan biosynthesis 0.594782609 0 0 kegg kegg NA NA no no no no no no Legionellosis Non-alcoholic fatty liver disease -0.432173913 0 0 kegg kegg NA NA no no no no no no Legionellosis Non-homologous end-joining 0.492173913 0 0.58996139 kegg kegg NA NA no no no no no no Legionellosis Notch signaling pathway -0.626086957 -0.429841897 -0.591248391 kegg kegg NA NA no no no no no no Legionellosis Odoribacter 0 0.440813635 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Legionellosis Other glycan degradation 0.555652174 0 0 kegg kegg NA NA no no no no no no Legionellosis Ovarian steroidogenesis -0.464347826 0 0 kegg kegg NA NA no no no no up up Legionellosis Pancreatic secretion -0.576521739 0 0 kegg kegg NA NA no no no no no no Legionellosis Pantothenate and CoA biosynthesis 0 -0.435770751 0 kegg kegg NA NA no no no no no dn Legionellosis Pentose and glucuronate interconversions 0.420869565 0 0 kegg kegg NA NA no no no no no no Legionellosis Phosphatidylinositol signaling system -0.433913043 0 0 kegg kegg NA NA no no no no no no Legionellosis Phospholipase D signaling pathway -0.537391304 -0.559288538 -0.404375804 kegg kegg NA NA no no no no up up Legionellosis PI3K-Akt signaling pathway 0.626086957 0.693675889 0.497297297 yes kegg kegg NA NA no no no no up up Legionellosis Primary bile acid biosynthesis 0.424347826 0 0 kegg kegg NA NA no no no no no no Legionellosis Prion disease 0 0.444664032 0 kegg kegg NA NA no no no no no no Legionellosis Prolactin signaling pathway -0.452173913 0 0 kegg kegg NA NA no no no no no no Legionellosis Propanoate metabolism 0.663478261 0.577075099 0.503989704 kegg kegg NA NA no no no no no no Legionellosis Protein processing in endoplasmic reticulum 0 0 0.481338481 kegg kegg NA NA no no no no no no Legionellosis Pyrimidine metabolism 0.437391304 0 0 kegg kegg NA NA no no no no no no Legionellosis Pyruvate metabolism 0.534782609 0.541501976 0.47001287 kegg kegg NA NA no no no no no no Legionellosis Ras signaling pathway 0 0 -0.436808237 yes kegg kegg NA NA no no no no up up Legionellosis Retinol metabolism 0.566086957 0 0 kegg kegg NA NA no no no no no no Legionellosis Ribosome 0 0.644268775 0.516344916 kegg kegg NA NA no no no no no no Legionellosis RNA transport 0.892173913 0.862648221 0.845817246 kegg kegg NA NA no no no no no no Legionellosis Salivary secretion -0.415652174 0 0 kegg kegg NA NA no no no no no no Legionellosis Shigellosis 0 0.416996047 0 kegg kegg NA NA no no no no no no Legionellosis SNARE interactions in vesicular transport 0 -0.43083004 0 kegg kegg NA NA no no no no no no Legionellosis Spliceosome 0.524347826 0 0 kegg kegg NA NA no no no no no no Legionellosis Starch and sucrose metabolism 0 -0.416996047 0 kegg kegg NA NA no no no no no no Legionellosis T cell receptor signaling pathway 0.445217391 0 0 kegg kegg NA NA no no no no no no Legionellosis Taste transduction 0 0 -0.407464607 kegg kegg NA NA no no no no no up Legionellosis Taurine and hypotaurine metabolism 0 -0.450592885 0 kegg kegg NA NA no no no no no no Legionellosis Thermogenesis -0.466086957 0.422924901 0 kegg kegg NA NA no no no no no no Legionellosis Thiamine metabolism 0.577391304 0.5256917 0 kegg kegg NA NA no no no no no no Legionellosis Thyroid hormone signaling pathway -0.48 0 0 kegg kegg NA NA no no no no no no Legionellosis Tryptophan metabolism 0.43826087 0 0 kegg kegg NA NA no no no no up no Legionellosis Type II diabetes mellitus 0 0 -0.425740026 kegg kegg NA NA no no no no no no Legionellosis "Valine, leucine and isoleucine degradation" 0.485217391 0 0 kegg kegg NA NA no no no no no no Legionellosis Vasopressin-regulated water reabsorption -0.562608696 0 0 kegg kegg NA NA no no no no no no Legionellosis VEGF signaling pathway -0.41826087 0 0 kegg kegg NA NA no no no no no no Legionellosis Vitamin digestion and absorption -0.674782609 -0.486166008 -0.513770914 kegg kegg NA NA no no no no no no Legionellosis Wnt signaling pathway -0.539130435 0 0 kegg kegg NA NA no no no no no no Leishmaniasis 2-Oxocarboxylic acid metabolism 0.514782609 0 0 kegg kegg NA NA no no no no no no Leishmaniasis ABC transporters 0.594782609 -0.610671937 -0.477220077 kegg kegg NA NA no no no no up up Leishmaniasis Adrenergic signaling in cardiomyocytes -0.659130435 0 0 kegg kegg NA NA no no no no no up Leishmaniasis AGE-RAGE signaling pathway in diabetic complications 0 -0.414031621 0 kegg kegg NA NA no no no no no no Leishmaniasis Aldosterone synthesis and secretion -0.630434783 0 0 kegg kegg NA NA no no no no up up Leishmaniasis Aldosterone-regulated sodium reabsorption -0.45826087 0 0 kegg kegg NA NA no no no no no no Leishmaniasis alpha-Linolenic acid metabolism 0.590434783 -0.4743083 0 kegg kegg NA NA no no no no no no Leishmaniasis Alzheimer disease -0.571304348 0 -0.400772201 kegg kegg NA NA no no no no no no Leishmaniasis Amino sugar and nucleotide sugar metabolism 0.629565217 -0.479249012 0 kegg kegg NA NA no no no no no no Leishmaniasis Aminoacyl-tRNA biosynthesis 0.665217391 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Amphetamine addiction -0.573043478 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Amyotrophic lateral sclerosis -0.527826087 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Antifolate resistance 0 0 -0.462033462 kegg kegg NA NA no no no no no no Leishmaniasis Antigen processing and presentation 0 0.460474308 0.477220077 kegg kegg NA NA no no no no no no Leishmaniasis Apelin signaling pathway 0 0.654150198 0 kegg kegg NA NA no no no no no no Leishmaniasis Apoptosis - multiple species 0 -0.531620553 0 kegg kegg NA NA no no no no no no Leishmaniasis Bacterial invasion of epithelial cells 0 0.43083004 0 kegg kegg NA NA no no no no no no Leishmaniasis Bacteroides 0 0.499011858 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Leishmaniasis Base excision repair 0.429565217 0 0 kegg kegg NA NA no no no no no no Leishmaniasis beta-Alanine metabolism 0.6 0 0.452252252 kegg kegg NA NA no no no no no no Leishmaniasis Bile secretion -0.673913043 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Biosynthesis of amino acids 0.550434783 0 0.448391248 kegg kegg NA NA no no no no no no Leishmaniasis Biosynthesis of unsaturated fatty acids 0.532173913 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Butanoate metabolism 0.624347826 0.414031621 0.425740026 kegg kegg NA NA no no no no no no Leishmaniasis Butyricimonas -0.479143606 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Leishmaniasis Calcium signaling pathway -0.65826087 0 0 kegg kegg NA NA no no no no up up Leishmaniasis cAMP signaling pathway -0.656521739 0 0 yes kegg kegg NA NA no no no no up up Leishmaniasis Carbon metabolism 0.602608696 0.588932806 0.45997426 kegg kegg NA NA no no no no no no Leishmaniasis Cardiac muscle contraction -0.530434783 0 0 kegg kegg NA NA no no no no no up Leishmaniasis Cholesterol metabolism 0 0.546442688 0 yes kegg kegg NA NA no no no no no up Leishmaniasis Cholinergic synapse 0 0 -0.456628057 kegg kegg NA NA no no no no no no Leishmaniasis Circadian entrainment -0.444347826 0 0 kegg kegg NA NA no no no no up up Leishmaniasis Citrate cycle (TCA cycle) 0.45826087 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Cocaine addiction -0.48173913 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Complement and coagulation cascades 0.425217391 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Cortisol synthesis and secretion -0.513043478 0 0 kegg kegg NA NA no no no no no up Leishmaniasis Cushing syndrome -0.473043478 0 0 kegg kegg NA NA no no no no no up Leishmaniasis Cysteine and methionine metabolism 0.443478261 0.536561265 0 kegg kegg NA NA no no no no no no Leishmaniasis Dopaminergic synapse -0.636521739 0 0 kegg kegg NA NA no no no no up no Leishmaniasis Drug metabolism - cytochrome P450 0.52173913 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Drug metabolism - other enzymes 0.58 0.444664032 0 kegg kegg NA NA no no no no no no Leishmaniasis EGFR tyrosine kinase inhibitor resistance 0 0.691699605 0 kegg kegg NA NA no no no no no no Leishmaniasis Endocrine and other factor-regulated calcium reabsorption -0.646086957 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Endocrine resistance -0.70173913 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Ether lipid metabolism -0.506086957 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Fanconi anemia pathway 0.459130435 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Fatty acid degradation 0.446086957 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Fatty acid elongation 0.551304348 0.545454545 0.447619048 kegg kegg NA NA no no no no no no Leishmaniasis Fatty acid metabolism 0.548695652 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Fc epsilon RI signaling pathway -0.477391304 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Fc gamma R-mediated phagocytosis 0 0 0.406435006 kegg kegg NA NA no no no no no no Leishmaniasis Ferroptosis -0.426956522 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Focal adhesion 0 0.43083004 0 kegg kegg NA NA no no no no up up Leishmaniasis Folate biosynthesis 0 0 -0.533590734 kegg kegg NA NA no no no no no no Leishmaniasis FoxO signaling pathway 0 -0.463438735 0 kegg kegg NA NA no no no no no no Leishmaniasis Fructose and mannose metabolism 0.628695652 -0.468379447 0 kegg kegg NA NA no no no no no no Leishmaniasis Galactose metabolism 0.53826087 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Gap junction 0 -0.467391304 0 kegg kegg NA NA no no no no no no Leishmaniasis Glutamatergic synapse -0.547826087 -0.565217391 0 kegg kegg NA NA no no no no up up Leishmaniasis Glycerolipid metabolism 0 -0.595849802 -0.511196911 kegg kegg NA NA no no no no no up Leishmaniasis Glycerophospholipid metabolism 0 -0.672924901 -0.512483912 kegg kegg NA NA no no no no no up Leishmaniasis Glycolysis / Gluconeogenesis 0.674782609 0.747035573 0.593307593 kegg kegg NA NA no no no no no no Leishmaniasis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.476284585 0 kegg kegg NA NA no no no no no no Leishmaniasis Glycosaminoglycan biosynthesis - keratan sulfate -0.549565217 0 -0.483140283 kegg kegg NA NA no no no no no no Leishmaniasis Glycosphingolipid biosynthesis - lacto and neolacto series -0.414782609 0 -0.418018018 kegg kegg NA NA no no no no no no Leishmaniasis GnRH secretion -0.444347826 0 -0.532818533 kegg kegg NA NA no no no no up up Leishmaniasis GnRH signaling pathway -0.53826087 0 0 kegg kegg NA NA no no no no no no Leishmaniasis "Growth hormone synthesis, secretion and action" -0.633913043 -0.575098814 0 kegg kegg NA NA no no no no no no Leishmaniasis Hedgehog signaling pathway -0.579130435 0 -0.411583012 kegg kegg NA NA no no no no no no Leishmaniasis Hematopoietic cell lineage 0 0.442687747 0 kegg kegg NA NA no no no no no no Leishmaniasis HIF-1 signaling pathway 0 0.790513834 0.491891892 kegg kegg NA NA no no no no no no Leishmaniasis Hippo signaling pathway - multiple species 0 -0.566205534 -0.420592021 kegg kegg NA NA no no no no no no Leishmaniasis Homologous recombination 0.52 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Huntington disease -0.546956522 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Inflammatory mediator regulation of TRP channels -0.640869565 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Inositol phosphate metabolism 0 0 -0.464607465 kegg kegg NA NA no no no no no no Leishmaniasis Insulin secretion -0.51826087 0 0 yes kegg kegg NA NA no no no no up up Leishmaniasis Insulin signaling pathway 0 0.664031621 0 kegg kegg NA NA no no no no no no Leishmaniasis Intestinal immune network for IgA production 0 0.463438735 0.428571429 kegg kegg NA NA no no no no no no Leishmaniasis JAK-STAT signaling pathway 0 -0.559288538 0 kegg kegg NA NA no no no no no no Leishmaniasis Legionellosis 0.874782609 0.93083004 0.932818533 kegg kegg NA NA no no no no no no Leishmaniasis Leukocyte transendothelial migration 0 0.509881423 0 kegg kegg NA NA no no no no no no Leishmaniasis Long-term depression -0.749565217 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Long-term potentiation 0 0.463438735 0 kegg kegg NA NA no no no no no up Leishmaniasis Longevity regulating pathway -0.508695652 -0.459486166 0 kegg kegg NA NA no no no no no no Leishmaniasis Longevity regulating pathway - multiple species 0 0 0.41981982 kegg kegg NA NA no no no no no no Leishmaniasis Mannose type O-glycan biosynthesis 0 0 -0.511454311 kegg kegg NA NA no no no no no no Leishmaniasis Maturity onset diabetes of the young -0.45826087 -0.419960474 -0.508365508 kegg kegg NA NA no no no no up no Leishmaniasis Melanogenesis -0.567826087 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Metabolism of xenobiotics by cytochrome P450 0.528695652 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Mineral absorption -0.539130435 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Mismatch repair 0.547826087 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Morphine addiction -0.637391304 0 0 kegg kegg NA NA no no no no up up Leishmaniasis mRNA surveillance pathway -0.446956522 0 0 kegg kegg NA NA no no no no no no Leishmaniasis mTOR signaling pathway 0 0.671936759 0.416473616 kegg kegg NA NA no no no no no no Leishmaniasis Mucin type O-glycan biosynthesis 0.502608696 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Necroptosis -0.480869565 0 0 kegg kegg NA NA no no no no no no Leishmaniasis NF-kappa B signaling pathway 0 -0.471343874 0 kegg kegg NA NA no no no no no no Leishmaniasis Non-alcoholic fatty liver disease -0.617391304 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Non-homologous end-joining 0.597391304 0.526679842 0.502187902 kegg kegg NA NA no no no no no no Leishmaniasis Notch signaling pathway -0.566086957 -0.503952569 -0.66023166 kegg kegg NA NA no no no no no no Leishmaniasis Nucleotide excision repair 0.420869565 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Odoribacter 0 0.593364871 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Leishmaniasis Oocyte meiosis 0 0.470355731 0 kegg kegg NA NA no no no no no no Leishmaniasis Other glycan degradation 0.645217391 -0.429841897 0 kegg kegg NA NA no no no no no no Leishmaniasis Other types of O-glycan biosynthesis 0 -0.449604743 -0.438867439 kegg kegg NA NA no no no no no no Leishmaniasis Ovarian steroidogenesis -0.553913043 0 0 kegg kegg NA NA no no no no up up Leishmaniasis Oxidative phosphorylation -0.535652174 0 0 kegg kegg NA NA no no no no no no Leishmaniasis p53 signaling pathway 0 -0.576086957 0 kegg kegg NA NA no no no no no no Leishmaniasis Pancreatic secretion -0.684347826 0 0 kegg kegg NA NA no no no no no no Leishmaniasis "Parathyroid hormone synthesis, secretion and action" -0.487826087 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Parkinson disease -0.546086957 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Pathways of neurodegeneration - multiple diseases -0.533913043 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Pentose and glucuronate interconversions 0.447826087 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Peroxisome 0 0 0.420849421 kegg kegg NA NA no no no no no no Leishmaniasis Phosphatidylinositol signaling system -0.469565217 0 -0.503474903 kegg kegg NA NA no no no no no no Leishmaniasis Phospholipase D signaling pathway -0.573043478 -0.59486166 0 kegg kegg NA NA no no no no up up Leishmaniasis Phototransduction 0 0.513833992 0 kegg kegg NA NA no no no no no no Leishmaniasis PI3K-Akt signaling pathway 0.414782609 0.493083004 0 yes kegg kegg NA NA no no no no up up Leishmaniasis Platinum drug resistance 0 -0.479249012 0 kegg kegg NA NA no no no no no no Leishmaniasis Primary bile acid biosynthesis 0.53826087 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Prion disease -0.50173913 0.42687747 0 kegg kegg NA NA no no no no no no Leishmaniasis Prolactin signaling pathway -0.58173913 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Propanoate metabolism 0.548695652 0.578063241 0 kegg kegg NA NA no no no no no no Leishmaniasis Proteasome 0 0.480237154 0 kegg kegg NA NA no no no no no no Leishmaniasis Protein export 0 0.416996047 0 kegg kegg NA NA no no no no no no Leishmaniasis Pyrimidine metabolism 0.602608696 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Pyruvate metabolism 0.463478261 0.510869565 0 kegg kegg NA NA no no no no no no Leishmaniasis Ras signaling pathway 0 0 -0.54980695 yes kegg kegg NA NA no no no no up up Leishmaniasis Regulation of lipolysis in adipocytes -0.651304348 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Relaxin signaling pathway -0.412173913 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Retinol metabolism 0.553043478 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Ribosome 0 0.579051383 0 kegg kegg NA NA no no no no no no Leishmaniasis RNA transport 0.756521739 0.804347826 0.705276705 kegg kegg NA NA no no no no no no Leishmaniasis Salmonella infection 0 0.453557312 0.414414414 kegg kegg NA NA no no no no no no Leishmaniasis Selenocompound metabolism 0 -0.421936759 0 kegg kegg NA NA no no no no no no Leishmaniasis Signaling pathways regulating pluripotency of stem cells -0.413043478 0 -0.437580438 kegg kegg NA NA no no no no no no Leishmaniasis SNARE interactions in vesicular transport 0.517391304 -0.503952569 0 kegg kegg NA NA no no no no no no Leishmaniasis Sphingolipid signaling pathway -0.556521739 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Spliceosome 0.412173913 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Steroid hormone biosynthesis 0.44173913 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Taste transduction 0 0 -0.518661519 kegg kegg NA NA no no no no no up Leishmaniasis Taurine and hypotaurine metabolism 0 -0.605731225 -0.435521236 kegg kegg NA NA no no no no no no Leishmaniasis Thermogenesis -0.572173913 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Thiamine metabolism 0.553913043 0.4743083 0 kegg kegg NA NA no no no no no no Leishmaniasis Tryptophan metabolism 0.570434783 0 0 kegg kegg NA NA no no no no up no Leishmaniasis Type II diabetes mellitus 0 -0.479249012 0 kegg kegg NA NA no no no no no no Leishmaniasis Ubiquinone and other terpenoid-quinone biosynthesis 0.510434783 0 0 kegg kegg NA NA no no no no no no Leishmaniasis "Valine, leucine and isoleucine degradation" 0.576521739 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Vascular smooth muscle contraction -0.554782609 0 0 kegg kegg NA NA no no no no no no Leishmaniasis Vasopressin-regulated water reabsorption -0.666956522 0 0 kegg kegg NA NA no no no no no no Leishmaniasis VEGF signaling pathway -0.503478261 0 -0.421879022 kegg kegg NA NA no no no no no no Leishmaniasis Vitamin digestion and absorption -0.7 -0.427865613 -0.567567568 kegg kegg NA NA no no no no no no Leishmaniasis Wnt signaling pathway -0.54 0 -0.468211068 kegg kegg NA NA no no no no no no Leptin 13-HODE+blood 0 -0.674019608 0 DM-assocaited hormones serum_ARA 0.706 0.32 no no no no no no Leptin 14:0/18:2-PC+blood 0.605779154 0 0 DM-assocaited hormones serum_phospholipids 0.706 0.102 no no no no up no Leptin 16:0/16:1-PC+blood 0 0 0.447826087 DM-assocaited hormones serum_phospholipids 0.706 0.00283 no no no up up no Leptin 16:0/18:2-PI+blood 0 0 0.530434783 DM-assocaited hormones serum_phospholipids 0.706 0.269 no no no no no no Leptin 16:0/18:3-PC+blood 0.539731682 0 0 DM-assocaited hormones serum_phospholipids 0.706 0.00216 no no no no up up Leptin 16:0/20:4-PC+blood 0 -0.507352941 0 DM-assocaited hormones serum_phospholipids 0.706 0.0262 no no no no up no Leptin 16:0/20:4-PI+blood 0 0.585784314 0.468695652 DM-assocaited hormones serum_phospholipids 0.706 0.558 no no no no no no Leptin 16:0/20:5-PC+blood 0.570691434 0 0 DM-assocaited hormones serum_phospholipids 0.706 0.628 no no no no no no Leptin 16:0+blood 0 -0.558823529 0 yes DM-assocaited hormones serum_fattyacid 0.706 0.00876 no no no up no no Leptin 18:0/18:0-PC+blood 0 0.671568627 0 DM-assocaited hormones serum_phospholipids 0.706 0.426 no no no no no no Leptin 18:0/18:0-PS+blood 0 0.5 0 DM-assocaited hormones serum_phospholipids 0.706 0.00617 no no no no up no Leptin 18:0/18:1-PC+blood 0 0.68627451 0 DM-assocaited hormones serum_phospholipids 0.706 0.393 no no no no no no Leptin 18:0/18:1-PE+blood 0 0.504901961 0 DM-assocaited hormones serum_phospholipids 0.706 0.00716 no no no up up no Leptin 18:0/20:2-PC+blood 0 0.5 0 DM-assocaited hormones serum_phospholipids 0.706 0.733 no no no no no no Leptin 18:0/20:3-PC+blood 0 0.727941176 0 DM-assocaited hormones serum_phospholipids 0.706 0.0682 no no no no up no Leptin 18:0/20:4-PI+blood -0.59752322 0 0 DM-assocaited hormones serum_phospholipids 0.706 0.167 no no no no no no Leptin 18:0/22:6-PC+blood 0.599587203 0 0 DM-assocaited hormones serum_phospholipids 0.706 0.0775 no no no no no up Leptin 18:1-LPC+blood -0.614035088 0 0 DM-assocaited hormones serum_phospholipids 0.706 0.179 no no no no no no Leptin 18:2-LPC+blood 0 -0.644607843 0 DM-assocaited hormones serum_phospholipids 0.706 0.00743 no no no dn no up Leptin 18:2/16:0-PC+blood 0 -0.62745098 0 DM-assocaited hormones serum_phospholipids 0.706 8.67E-05 no no no no up up Leptin 18:3n6+blood 0 0 0.493913043 DM-assocaited hormones serum_fattyacid 0.706 0.0463 no no no up no dn Leptin 20:2/18:0-PC+blood 0.479876161 0.735294118 0 DM-assocaited hormones serum_phospholipids 0.706 0.0427 no no no no up no Leptin 20:3/16:0-PC+blood 0 -0.526960784 0 DM-assocaited hormones serum_phospholipids 0.706 0.00405 no no no no up up Leptin 20:3n6+blood 0 0.487745098 0 DM-assocaited hormones serum_fattyacid 0.706 0.0884 no no no up no no Leptin 20:4-LPC+blood 0 -0.56372549 0 DM-assocaited hormones serum_phospholipids 0.706 0.949 no no no no no no Leptin 20:4n6+blood 0 -0.556372549 0 DM-assocaited hormones serum_fattyacid 0.706 0.133 no no no no no no Leptin 20:5n3+blood 0.55624355 0 0 DM-assocaited hormones serum_fattyacid 0.706 0.988 no no no no no no Leptin 22:6n3+blood 0.634674923 0 0 DM-assocaited hormones serum_fattyacid 0.706 0.792 no no no no no no Leptin 8-HETE+blood 0 -0.656862745 0 DM-assocaited hormones serum_ARA 0.706 0.741 no no no no no no Leptin 9-HODE+blood 0 -0.50245098 0 DM-assocaited hormones serum_ARA 0.706 0.297 no no no no no no Leptin AA+blood 0 -0.568627451 0 DM-assocaited hormones serum_ARA 0.706 0.212 no no no no no no Leptin Alistipes -0.478951444 0 0 DM-assocaited hormones Genus 0.706 0.0114 no no no no up no Leptin Alzheimer disease -0.438735178 0 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin Amyotrophic lateral sclerosis -0.453416149 0 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin Betaine+blood -0.473684211 -0.649509804 -0.411304348 DM-assocaited hormones serum_choline 0.706 0.857 no no no no no no Leptin Biosynthesis of cofactors 0 0.455533597 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin Butyric acid+stool 0 0 -0.445454545 yes DM-assocaited hormones stool_scfa 0.706 0.102 no no no dn no no Leptin cAMP signaling pathway 0 -0.5 0 yes DM-assocaited hormones kegg 0.706 NA no no no no up up Leptin Cardiac muscle contraction -0.43083004 0 0 DM-assocaited hormones kegg 0.706 NA no no no no no up Leptin CDCA+blood 0 0 0.424347826 DM-assocaited hormones serum_bileacids 0.706 0.506 no no no no no no Leptin CDCA+stool 0.632352941 0 0 DM-assocaited hormones stool_bileacids 0.706 0.663 no no no no no no Leptin Central carbon metabolism in cancer 0 0.467391304 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin Choline+blood 0 -0.50245098 0 DM-assocaited hormones serum_choline 0.706 0.0395 no no no no up no Leptin Cocaine addiction 0 0 0.415106952 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin Coprococcus 0.436758893 0 0 butyrate-producing DM-assocaited hormones Genus 0.706 0.612 no no no no no no Leptin Creatinine+blood -0.492260062 0 0 DM-assocaited hormones serum_choline 0.706 0.437 no no no no no no Leptin DHA+blood 0 -0.639705882 0 DM-assocaited hormones serum_ARA 0.706 0.872 no no no no no no Leptin Diabetic cardiomyopathy -0.440993789 0 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin DL-Indole-3-lactic acid+urine 0 -0.531578947 0 DM-assocaited hormones urine_cometabolism 0.706 0.00552 no no no up up no Leptin DPA+blood 0 -0.575980392 0 DM-assocaited hormones serum_ARA 0.706 0.519 no no no no no no Leptin Faecalibacterium 0 0 0.406587346 butyrate-producing DM-assocaited hormones Genus 0.706 0.0039 no no no no dn dn Leptin Gap junction 0 -0.43972332 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin GCA+stool 0.520588235 0 0 DM-assocaited hormones stool_bileacids 0.706 0.0809 no no no no no no Leptin GCDCA+stool 0 0 0.445454545 yes DM-assocaited hormones stool_bileacids 0.706 0.0471 no no no no dn no Leptin GLCA+blood 0 0 -0.417028828 DM-assocaited hormones serum_bileacids 0.706 0.319 no no no no no no Leptin GLP-1 -0.497035573 0 0 DM-assocaited hormones DM-assocaited hormones 0.706 0.256 no no no no no no Leptin Glucagon -0.649209486 -0.42173913 0 DM-assocaited hormones DM-assocaited hormones 0.706 0.0283 no no no no no up Leptin "Glycine, serine and threonine metabolism" 0 0.419960474 0 DM-assocaited hormones kegg 0.706 NA no no no no up no Leptin GUDCA+blood 0 0.507352941 0 DM-assocaited hormones serum_bileacids 0.706 0.0766 no no no no no dn Leptin HCA+blood 0 0 0.43953907 DM-assocaited hormones serum_bileacids 0.706 0.544 no no no no no no Leptin Human papillomavirus infection 0.426312818 0 0.44618984 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin Huntington disease -0.451157538 0 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin Hypotaurine+blood -0.595459236 -0.551470588 -0.526956522 DM-assocaited hormones serum_aminoacids 0.706 0.933 no no no no no no Leptin IP-10 0 0.611688312 0 DM-assocaited hormones serum_cytokines 0.706 0.394 no no no no no no Leptin iso-LCA+stool -0.609271688 0 0 DM-assocaited hormones stool_bileacids 0.706 0.72 no no no no no no Leptin L-Citrulline+blood 0 0 -0.452173913 DM-assocaited hormones serum_aminoacids 0.706 0.534 no no no no no no Leptin L-Homocystine+blood 0 0 -0.447826087 DM-assocaited hormones serum_aminoacids 0.706 0.197 no no no no no no Leptin L-Methionine+blood 0 0 -0.56173913 DM-assocaited hormones serum_aminoacids 0.706 0.626 no no no no no no Leptin L-Phenylalanine+stool -0.538235294 0 0 DM-assocaited hormones stool_cometabolism 0.706 0.398 no no no no no no Leptin L-Tryptophan+blood 0 0 -0.460869565 DM-assocaited hormones serum_aminoacids 0.706 0.164 no no no no no no Leptin L-Tyrosine+blood 0 0.539215686 0 yes DM-assocaited hormones serum_aminoacids 0.706 0.00913 no no no up up no Leptin Long-term depression 0 -0.546442688 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin n3+blood 0.684210526 0 0 DM-assocaited hormones serum_fattyacid 0.706 0.806 no no no no no no Leptin n6/n3+blood -0.673890609 0 0 DM-assocaited hormones serum_fattyacid 0.706 0.226 no no no no no no Leptin nutriCA+stool 0 0.76058224 0 DM-assocaited hormones stool_bileacids 0.706 0.481 no no no no no no Leptin Oxidative phosphorylation -0.459062676 0 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin P-hydroxyhippuric acid+urine 0.477812178 0 0 DM-assocaited hormones urine_cometabolism 0.706 0.436 no no no no no no Leptin PDGF-bb 0 -0.675324675 0 yes DM-assocaited hormones serum_cytokines 0.706 0.111 no no no no no no Leptin Phenylacetic acid+stool -0.685294118 0 0 DM-assocaited hormones stool_cometabolism 0.706 0.785 no no no no no no Leptin Phenylacetyl L-GlutaMine+urine 0 -0.457894737 0 DM-assocaited hormones urine_cometabolism 0.706 0.0909 no no no up no no Leptin Porphyrin and chlorophyll metabolism 0 0.511857708 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin PUFA/MUFA+blood 0 -0.585784314 0 DM-assocaited hormones serum_fattyacid 0.706 0.00108 no no no dn no up Leptin PUFA%+blood 0 -0.573529412 0 DM-assocaited hormones serum_fattyacid 0.706 0.0013 no no no dn no up Leptin Purine metabolism 0 0.437747036 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin Relaxin signaling pathway 0 -0.501976285 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin Ruminococcus 0 0.511304348 0 acetate-producing DM-assocaited hormones Genus 0.706 0.335 no no no no no no Leptin Salivary secretion 0 -0.420948617 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin Sarcosine+blood 0 0 0.486956522 DM-assocaited hormones serum_choline 0.706 5.06E-05 no no no up up no Leptin Serotonergic synapse 0 -0.459486166 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin Thermogenesis -0.470355731 0 0 DM-assocaited hormones kegg 0.706 NA no no no no no no Leptin total_stool_scfa+stool 0 0 -0.522077922 DM-assocaited hormones stool_scfa 0.706 0.0534 no no no dn no up Leptin UDCA+blood 0 0 0.450545732 yes DM-assocaited hormones serum_bileacids 0.706 0.0939 no no no no no dn Leukocyte transendothelial migration ABC transporters 0 -0.791501976 -0.428828829 kegg kegg NA NA no no no no up up Leukocyte transendothelial migration Adherens junction 0.766086957 0.722332016 0.723809524 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Amino sugar and nucleotide sugar metabolism 0 -0.583003953 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Antigen processing and presentation 0 0.585968379 0.421621622 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Apelin signaling pathway -0.489565217 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Apoptosis 0.628695652 0 0.631917632 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Apoptosis - multiple species -0.700869565 -0.806324111 -0.415701416 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Autophagy - animal 0 -0.441699605 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Autophagy - other -0.660869565 -0.708498024 -0.476447876 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Axon guidance 0 0.658102767 0 kegg kegg NA NA no no no no up up Leukocyte transendothelial migration Basal transcription factors -0.760869565 -0.443675889 -0.609009009 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Base excision repair -0.72 -0.551383399 -0.486743887 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Bifidobacterium 0 0.445766597 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Leukocyte transendothelial migration Biosynthesis of amino acids 0.431304348 0 0.572715573 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Butyricicoccus -0.482818593 0 0 butyrate-producing kegg Genus NA 0.852 no no no no no no Leukocyte transendothelial migration Carbon metabolism 0 0.730237154 0.592792793 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Cell adhesion molecules 0.586086957 0.466403162 0.569111969 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Cell cycle -0.54 0 -0.494208494 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Cellular senescence 0.494782609 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Chemokine signaling pathway 0.476521739 0 0.547232947 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Clostridium 0 0.536910485 0 kegg Genus NA 0.925 no no no no no no Leukocyte transendothelial migration Complement and coagulation cascades 0.442608696 0 0.754440154 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Cytokine-cytokine receptor interaction 0 0 0.576319176 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration DNA replication -0.527826087 0 -0.468725869 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration EGFR tyrosine kinase inhibitor resistance -0.489565217 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Endocytosis 0.586956522 0.475296443 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Fanconi anemia pathway -0.566956522 -0.653162055 -0.509137709 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Fc gamma R-mediated phagocytosis 0 0 0.552123552 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Focal adhesion 0.823478261 0.740118577 0.718918919 kegg kegg NA NA no no no no up up Leukocyte transendothelial migration FoxO signaling pathway 0 -0.56916996 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Fructose and mannose metabolism 0 -0.485177866 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Glycerolipid metabolism 0 -0.710474308 0 kegg kegg NA NA no no no no no up Leukocyte transendothelial migration Glycerophospholipid metabolism -0.667826087 -0.882411067 -0.554954955 kegg kegg NA NA no no no no no up Leukocyte transendothelial migration Glycolysis / Gluconeogenesis 0 0.532608696 0.406177606 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.467826087 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Glycosaminoglycan degradation 0.486956522 0 0 kegg kegg NA NA no no no no no up Leukocyte transendothelial migration Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.49826087 -0.759881423 -0.468983269 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Hedgehog signaling pathway 0 -0.510869565 -0.500643501 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration HIF-1 signaling pathway -0.502608696 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Hippo signaling pathway 0.66 0.592885375 0.637837838 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Homologous recombination -0.471304348 -0.816205534 -0.544144144 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Inositol phosphate metabolism 0 -0.746047431 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration JAK-STAT signaling pathway 0 -0.57312253 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Lachnospira 0 0.574746744 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Leukocyte transendothelial migration Longevity regulating pathway 0 -0.626482213 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Lysine degradation -0.577391304 -0.70256917 -0.588159588 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Lysosome 0.44173913 0.606719368 0.427541828 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Mannose type O-glycan biosynthesis 0 -0.518774704 -0.502187902 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration MAPK signaling pathway 0 -0.589920949 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration mRNA surveillance pathway -0.516521739 0 -0.565508366 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration mTOR signaling pathway -0.467826087 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Mucin type O-glycan biosynthesis 0 -0.48715415 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration N-Glycan biosynthesis -0.429565217 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Natural killer cell mediated cytotoxicity 0.636521739 0.455533597 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Neuroactive ligand-receptor interaction 0 0.480237154 0.587387387 kegg kegg NA NA no no no up up up Leukocyte transendothelial migration Neutrophil extracellular trap formation 0.606086957 0.456521739 0.687258687 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Nucleotide excision repair -0.54173913 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration One carbon pool by folate -0.447826087 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Other glycan degradation 0 -0.650197628 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Other types of O-glycan biosynthesis -0.726956522 -0.804347826 -0.634234234 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration p53 signaling pathway -0.787826087 -0.934782609 -0.738996139 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Pentose phosphate pathway 0.564347826 0.495059289 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Phagosome 0.659130435 0.593873518 0.683912484 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Phosphatidylinositol signaling system 0 0 -0.514543115 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration PI3K-Akt signaling pathway -0.433913043 0 0 yes kegg kegg NA NA no no no no up up Leukocyte transendothelial migration Platelet activation 0.769565217 0.735177866 0.76962677 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Platinum drug resistance -0.660869565 -0.751976285 -0.424453024 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Protein export -0.636521739 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Protein processing in endoplasmic reticulum -0.46173913 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Pyrimidine metabolism 0 0 -0.528700129 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Rap1 signaling pathway 0.890434783 0.751976285 0.794337194 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Renin-angiotensin system 0 0 0.458687259 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Ribosome -0.407826087 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Ribosome biogenesis in eukaryotes -0.711304348 -0.42687747 -0.540540541 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration RNA degradation -0.444347826 0 -0.509395109 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration RNA polymerase -0.785217391 0 -0.411840412 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Selenocompound metabolism -0.797391304 -0.713438735 -0.577863578 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Signaling pathways regulating pluripotency of stem cells 0 -0.479249012 -0.403861004 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration SNARE interactions in vesicular transport -0.440869565 -0.640316206 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Sphingolipid metabolism 0.47826087 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Sphingolipid signaling pathway 0 0.457509881 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Spliceosome -0.729565217 -0.821146245 -0.581724582 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration T cell receptor signaling pathway 0 -0.498023715 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Taurine and hypotaurine metabolism -0.526086957 -0.735177866 -0.532046332 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Terpenoid backbone biosynthesis -0.531304348 0 0 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Tight junction 0.619130435 0.769762846 0.627541828 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Viral protein interaction with cytokine and cytokine receptor 0.434782609 0.472332016 0.567824968 kegg kegg NA NA no no no no no no Leukocyte transendothelial migration Wnt signaling pathway 0 0 -0.411840412 kegg kegg NA NA no no no no no no Linoleic acid metabolism Amino sugar and nucleotide sugar metabolism 0.413913043 0 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Arachidonic acid metabolism 0.443478261 0.462450593 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Ascorbate and aldarate metabolism 0.426086957 0 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Ether lipid metabolism 0 0 0.452252252 kegg kegg NA NA no no no no no no Linoleic acid metabolism Glutathione metabolism 0.446956522 0 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Glycolysis / Gluconeogenesis 0.467826087 0 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.493913043 0 0.484169884 kegg kegg NA NA no no no no no no Linoleic acid metabolism Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.414157014 kegg kegg NA NA no no no no no no Linoleic acid metabolism Glycosaminoglycan degradation 0 -0.423913043 0 kegg kegg NA NA no no no no no up Linoleic acid metabolism Pentose and glucuronate interconversions 0.616521739 0 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Phenylalanine metabolism 0.509565217 0.45256917 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Pyrimidine metabolism 0 0.459486166 0 kegg kegg NA NA no no no no no no Linoleic acid metabolism Steroid hormone biosynthesis 0.408695652 0 0.418532819 kegg kegg NA NA no no no no no no Linoleic acid metabolism Tyrosine metabolism 0 0.479249012 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis 2-Oxocarboxylic acid metabolism 0 -0.497035573 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Acute myeloid leukemia 0 0.455533597 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Adherens junction 0 -0.416996047 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Adrenergic signaling in cardiomyocytes 0 -0.79743083 -0.494723295 kegg kegg NA NA no no no no no up Lipid and atherosclerosis African trypanosomiasis 0 0.518774704 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis AGE-RAGE signaling pathway in diabetic complications 0 0.735177866 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis "Alanine, aspartate and glutamate metabolism" 0.608695652 0.770750988 0.552895753 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Aldosterone synthesis and secretion -0.52173913 -0.887351779 -0.521750322 kegg kegg NA NA no no no no up up Lipid and atherosclerosis Alistipes -0.427951679 0 0 kegg Genus NA 0.0114 no no no no up no Lipid and atherosclerosis Allograft rejection 0 0.585968379 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis alpha-Linolenic acid metabolism 0 0.638339921 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Alzheimer disease 0 -0.770750988 -0.418275418 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Aminoacyl-tRNA biosynthesis 0 0 -0.466409266 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Amoebiasis 0 0.625494071 0.434491634 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Amphetamine addiction -0.466956522 -0.860671937 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis AMPK signaling pathway -0.743478261 -0.633399209 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Amyotrophic lateral sclerosis 0 -0.817193676 -0.435263835 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Antifolate resistance 0 -0.537549407 -0.423938224 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Antigen processing and presentation 0 0 0.588159588 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Apelin signaling pathway 0 -0.679841897 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Apoptosis 0.451304348 0.778656126 0.657400257 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Apoptosis - multiple species 0 0 -0.448391248 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Arginine and proline metabolism 0.683478261 0.791501976 0.612355212 kegg kegg NA NA no no no no up no Lipid and atherosclerosis Arginine biosynthesis 0.643478261 0.782608696 0.64041184 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Arrhythmogenic right ventricular cardiomyopathy 0 -0.509881423 0 kegg kegg NA NA no no no no up up Lipid and atherosclerosis Autoimmune thyroid disease 0 0.585968379 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Autophagy - animal 0.505217391 0.588932806 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis B cell receptor signaling pathway 0 0.721343874 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Basal cell carcinoma -0.526956522 -0.588932806 -0.537194337 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Basal transcription factors 0 -0.532608696 -0.615444015 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Base excision repair 0 -0.52173913 -0.612870013 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Bile secretion -0.413913043 -0.495059289 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Biosynthesis of amino acids 0 0.874505929 0.793822394 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Biosynthesis of cofactors -0.597391304 -0.618577075 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Bladder cancer 0.853043478 0.741106719 0.703474903 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Butanoate metabolism 0 -0.477272727 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis C-type lectin receptor signaling pathway 0.451304348 0.745059289 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Calcium signaling pathway 0 -0.686758893 -0.45045045 kegg kegg NA NA no no no no up up Lipid and atherosclerosis Carbon metabolism 0 0 0.645559846 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Cardiac muscle contraction 0 -0.767786561 0 kegg kegg NA NA no no no no no up Lipid and atherosclerosis Cell adhesion molecules 0 0.675889328 0.519176319 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Cell cycle 0 -0.779644269 -0.721492921 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Cellular senescence 0 0.638339921 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis cGMP-PKG signaling pathway 0.673913043 0.867588933 0.649420849 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Chagas disease 0 0.557312253 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Chemical carcinogenesis - DNA adducts 0.42 0.567193676 0.537451737 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Chemical carcinogenesis - receptor activation 0 -0.530632411 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Chemokine signaling pathway 0 0.595849802 0.601801802 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Cholesterol metabolism 0 0.564229249 0.5003861 yes kegg kegg NA NA no no no no no up Lipid and atherosclerosis Circadian entrainment 0 -0.527667984 0 kegg kegg NA NA no no no no up up Lipid and atherosclerosis Circadian rhythm 0 -0.685770751 -0.6 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Citrate cycle (TCA cycle) 0 -0.444664032 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Cocaine addiction -0.60173913 -0.610671937 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Complement and coagulation cascades 0 0.78458498 0.641698842 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Coronavirus disease - COVID-19 -0.543478261 -0.665019763 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Cortisol synthesis and secretion -0.62 -0.664031621 0 kegg kegg NA NA no no no no no up Lipid and atherosclerosis Cushing syndrome -0.693913043 -0.772727273 -0.558301158 kegg kegg NA NA no no no no no up Lipid and atherosclerosis Cysteine and methionine metabolism 0 -0.507905138 -0.46975547 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Diabetic cardiomyopathy 0 -0.755928854 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Dilated cardiomyopathy 0 -0.56916996 0 kegg kegg NA NA no no no no up up Lipid and atherosclerosis DNA replication 0 -0.675889328 -0.512741313 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Dopaminergic synapse 0 -0.731225296 0 kegg kegg NA NA no no no no up no Lipid and atherosclerosis Dorea 0 0 -0.408520526 kegg Genus NA 0.00362 no no no up no dn Lipid and atherosclerosis Drug metabolism - cytochrome P450 0 -0.583992095 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Drug metabolism - other enzymes 0 -0.503952569 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis ECM-receptor interaction -0.414782609 0 0 kegg kegg NA NA no no no no up up Lipid and atherosclerosis EGFR tyrosine kinase inhibitor resistance -0.411304348 -0.62944664 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Endocrine and other factor-regulated calcium reabsorption -0.590434783 -0.828063241 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Endocrine resistance -0.42 -0.561264822 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Endocytosis 0 0.70256917 0.519176319 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Epithelial cell signaling in Helicobacter pylori infection 0.626956522 0.848814229 0.736679537 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Epstein-Barr virus infection 0 0 0.525353925 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Estrogen signaling pathway 0 -0.513833992 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Ether lipid metabolism 0 -0.587944664 -0.58996139 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Fanconi anemia pathway 0 -0.453557312 -0.588931789 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Fat digestion and absorption 0.608695652 0.747035573 0.554954955 yes kegg kegg NA NA no no no no up up Lipid and atherosclerosis Fatty acid biosynthesis 0.714782609 0.789525692 0.552123552 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Fatty acid degradation 0.595652174 0.696640316 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Fatty acid metabolism 0.529565217 0.738142292 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Fc epsilon RI signaling pathway 0 0.799407115 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Fc gamma R-mediated phagocytosis 0.771304348 0.872529644 0.823680824 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Folate biosynthesis 0 -0.522727273 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis FoxO signaling pathway 0.480869565 0 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis GABAergic synapse 0.575652174 0.536561265 0.546460746 kegg kegg NA NA no no no no up up Lipid and atherosclerosis Galactose metabolism 0 0.600790514 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Gap junction -0.497391304 0 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Gastric acid secretion 0 -0.542490119 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Gastric cancer 0 0 -0.46023166 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Glucagon signaling pathway -0.493913043 -0.907114625 -0.60952381 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Glutathione metabolism -0.668695652 -0.733201581 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Glycerophospholipid metabolism 0 0 -0.519176319 kegg kegg NA NA no no no no no up Lipid and atherosclerosis "Glycine, serine and threonine metabolism" -0.665217391 -0.540513834 0 kegg kegg NA NA no no no no up no Lipid and atherosclerosis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.554782609 0.528656126 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.459486166 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Glycosaminoglycan biosynthesis - keratan sulfate -0.505217391 -0.51284585 -0.459202059 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Glycosaminoglycan degradation 0.414782609 0.669960474 0 kegg kegg NA NA no no no no no up Lipid and atherosclerosis Glycosphingolipid biosynthesis - ganglio series 0 0 -0.424195624 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.445652174 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Glyoxylate and dicarboxylate metabolism 0.546956522 0.808300395 0.661261261 kegg kegg NA NA no no no no no no Lipid and atherosclerosis GnRH signaling pathway -0.48 -0.661067194 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Graft-versus-host disease 0 0.585968379 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Hedgehog signaling pathway 0 -0.531620553 -0.626512227 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Hepatitis B 0.562608696 0.677865613 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Hepatitis C 0 0.415019763 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Hepatocellular carcinoma 0 -0.479249012 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Herpes simplex virus 1 infection 0 0 0.421621622 kegg kegg NA NA no no no no no no Lipid and atherosclerosis HIF-1 signaling pathway 0 -0.501976285 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Hippo signaling pathway 0 -0.506916996 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Hippo signaling pathway - multiple species 0.619130435 0.684782609 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Homologous recombination 0 0 -0.617503218 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Human cytomegalovirus infection 0 0 0.600514801 kegg kegg NA NA no no no no no dn Lipid and atherosclerosis Human immunodeficiency virus 1 infection 0 0 0.577091377 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Human papillomavirus infection 0 0.608695652 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Human T-cell leukemia virus 1 infection 0 0 0.483655084 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Huntington disease 0 -0.776679842 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis IL-17 signaling pathway 0.794782609 0.855731225 0.834749035 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Inflammatory mediator regulation of TRP channels -0.406086957 -0.820158103 -0.521492921 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Inositol phosphate metabolism 0 0 -0.534877735 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Insulin resistance 0 0.448616601 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Insulin secretion -0.700869565 -0.726284585 0 yes kegg kegg NA NA no no no no up up Lipid and atherosclerosis Insulin signaling pathway 0 -0.638339921 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis JAK-STAT signaling pathway 0 0.470355731 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Leukocyte transendothelial migration 0 0 0.524324324 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Longevity regulating pathway -0.416521739 0 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Lysine degradation 0 -0.442687747 -0.621879022 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Lysosome 0.528695652 0.780632411 0.72046332 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Mannose type O-glycan biosynthesis 0 -0.41798419 -0.602059202 kegg kegg NA NA no no no no no no Lipid and atherosclerosis MAPK signaling pathway 0.470434783 0 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Measles 0.46173913 0 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Melanogenesis -0.612173913 -0.806324111 -0.492664093 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Metabolism of xenobiotics by cytochrome P450 0 -0.469367589 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis MicroRNAs in cancer 0 0.505928854 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Mineral absorption -0.53826087 -0.472332016 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Mismatch repair 0 -0.488142292 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Mitophagy - animal -0.593043478 -0.602766798 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Morphine addiction -0.473913043 -0.722332016 0 kegg kegg NA NA no no no no up up Lipid and atherosclerosis mRNA surveillance pathway 0 -0.817193676 -0.702187902 kegg kegg NA NA no no no no no no Lipid and atherosclerosis mTOR signaling pathway -0.410434783 -0.608695652 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis N-Glycan biosynthesis 0 -0.78458498 -0.605405405 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Natural killer cell mediated cytotoxicity 0 0.665019763 0.508365508 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Necroptosis -0.433913043 0 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Neuroactive ligand-receptor interaction 0.593913043 0.796442688 0.824453024 kegg kegg NA NA no no no up up up Lipid and atherosclerosis Neurotrophin signaling pathway 0 0.498023715 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Neutrophil extracellular trap formation 0.576521739 0.802371542 0.792277992 kegg kegg NA NA no no no no no no Lipid and atherosclerosis NF-kappa B signaling pathway 0.511304348 0.635375494 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Nicotinate and nicotinamide metabolism 0.746956522 0.804347826 0.749292149 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Nitrogen metabolism 0.537391304 0.688735178 0.540540541 kegg kegg NA NA no no no no no no Lipid and atherosclerosis NOD-like receptor signaling pathway 0.837391304 0.840909091 0.601801802 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Non-alcoholic fatty liver disease 0 -0.717391304 -0.422651223 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Nucleotide excision repair 0 -0.613636364 -0.614414414 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Olfactory transduction 0.759130435 0.798418972 0.798455598 kegg kegg NA NA no no no no no no Lipid and atherosclerosis One carbon pool by folate 0 -0.67687747 -0.676190476 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Oocyte meiosis 0 0 -0.428571429 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Osteoclast differentiation 0.73826087 0.911067194 0.831145431 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Other types of O-glycan biosynthesis 0 -0.492094862 -0.672586873 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Ovarian steroidogenesis -0.533043478 -0.454545455 0 kegg kegg NA NA no no no no up up Lipid and atherosclerosis Oxidative phosphorylation 0 -0.743083004 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis p53 signaling pathway 0 0 -0.603603604 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Pancreatic secretion -0.435652174 -0.730237154 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Pantothenate and CoA biosynthesis 0.817391304 0.843873518 0.61029601 kegg kegg NA NA no no no no no dn Lipid and atherosclerosis "Parathyroid hormone synthesis, secretion and action" 0 -0.624505929 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Parkinson disease -0.482608696 -0.706521739 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Pathogenic Escherichia coli infection 0.55826087 0.747035573 0.645045045 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Pathways of neurodegeneration - multiple diseases -0.49826087 -0.716403162 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.574110672 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Pentose and glucuronate interconversions 0 -0.602766798 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Pentose phosphate pathway 0 0.830039526 0.75984556 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Peroxisome 0.633913043 0.82312253 0.574002574 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Pertussis 0.773913043 0.95256917 0.844015444 kegg kegg NA NA no no no no no dn Lipid and atherosclerosis Phagosome 0 0.73715415 0.682625483 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Phosphatidylinositol signaling system 0 -0.449604743 -0.613384813 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Phospholipase D signaling pathway 0 0.444664032 0 kegg kegg NA NA no no no no up up Lipid and atherosclerosis Platinum drug resistance 0 0 -0.516087516 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Porphyrin and chlorophyll metabolism -0.629565217 -0.477272727 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis PPAR signaling pathway 0.656521739 0.792490119 0.785328185 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Prion disease 0 -0.735177866 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Prolactin signaling pathway 0.41826087 0.641304348 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Propanoate metabolism 0 -0.446640316 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Prostate cancer 0 0.423913043 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Protein digestion and absorption 0 0.726284585 0 yes kegg kegg NA NA no no no no up up Lipid and atherosclerosis Protein export 0 -0.64229249 -0.43989704 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Protein processing in endoplasmic reticulum -0.517391304 -0.792490119 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Proteoglycans in cancer 0 -0.651185771 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Proximal tubule bicarbonate reclamation 0 -0.685770751 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Purine metabolism -0.593913043 -0.591897233 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Pyrimidine metabolism 0 -0.595849802 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Pyruvate metabolism 0 -0.602766798 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Ras signaling pathway 0 -0.627470356 -0.506821107 yes kegg kegg NA NA no no no no up up Lipid and atherosclerosis Regulation of lipolysis in adipocytes 0 -0.553359684 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Renin secretion -0.515652174 -0.722332016 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Renin-angiotensin system 0.626086957 0.849802372 0.615701416 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Retrograde endocannabinoid signaling 0 -0.708498024 0 kegg kegg NA NA no no no no no up Lipid and atherosclerosis Rheumatoid arthritis 0 0.830039526 0.470785071 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Ribosome -0.554782609 -0.684782609 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Ribosome biogenesis in eukaryotes 0 -0.678853755 -0.681338481 kegg kegg NA NA no no no no no no Lipid and atherosclerosis RIG-I-like receptor signaling pathway 0.519130435 0.633399209 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis RNA degradation 0 -0.824110672 -0.597425997 kegg kegg NA NA no no no no no no Lipid and atherosclerosis RNA polymerase 0 -0.795454545 -0.646846847 kegg kegg NA NA no no no no no no Lipid and atherosclerosis RNA transport 0 -0.497035573 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Salmonella infection 0.635652174 0.709486166 0.542599743 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Selenocompound metabolism 0 0 -0.545688546 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Shigellosis -0.500869565 -0.463438735 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Signaling pathways regulating pluripotency of stem cells 0 0 -0.502187902 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Small cell lung cancer 0 0.419960474 0 kegg kegg NA NA no no no no no up Lipid and atherosclerosis SNARE interactions in vesicular transport 0 0.445652174 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Sphingolipid signaling pathway 0 0.515810277 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Spinocerebellar ataxia 0 -0.638339921 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Spliceosome 0 0 -0.541827542 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Staphylococcus aureus infection 0 0.766798419 0.727927928 kegg kegg NA NA no no no up no no Lipid and atherosclerosis Starch and sucrose metabolism 0.587826087 0.805335968 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Steroid biosynthesis 0 0 -0.407464607 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Synaptic vesicle cycle 0.605217391 0.82312253 0.563963964 kegg kegg NA NA no no no no up up Lipid and atherosclerosis Synthesis and degradation of ketone bodies 0 -0.481225296 -0.413384813 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Systemic lupus erythematosus 0 0.750988142 0.600772201 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Taste transduction 0 -0.505928854 -0.594337194 kegg kegg NA NA no no no no no up Lipid and atherosclerosis Taurine and hypotaurine metabolism 0 0 -0.454054054 kegg kegg NA NA no no no no no no Lipid and atherosclerosis TGF-beta signaling pathway 0 -0.552371542 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Th1 and Th2 cell differentiation 0 0.433794466 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Th17 cell differentiation 0 0.466403162 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Thermogenesis 0 -0.789525692 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Thiamine metabolism 0 -0.479249012 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Thyroid hormone signaling pathway 0 -0.551383399 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Thyroid hormone synthesis -0.792173913 -0.688735178 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis TNF signaling pathway 0 0.544466403 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Toll-like receptor signaling pathway 0.526956522 0.783596838 0.651480051 yes kegg kegg NA NA no no no no no no Lipid and atherosclerosis Toxoplasmosis 0 0.695652174 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Transcriptional misregulation in cancer 0.493913043 0.57312253 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Tuberculosis 0.460869565 0.858695652 0.714800515 kegg kegg NA NA no no no no no dn Lipid and atherosclerosis Type I diabetes mellitus 0 0.587944664 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Tyrosine metabolism 0 -0.498023715 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Ubiquinone and other terpenoid-quinone biosynthesis 0 0 -0.566280566 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Ubiquitin mediated proteolysis -0.676521739 -0.70256917 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis "Valine, leucine and isoleucine degradation" 0 -0.444664032 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Various types of N-glycan biosynthesis 0 -0.624505929 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Vascular smooth muscle contraction -0.450434783 -0.600790514 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Vasopressin-regulated water reabsorption -0.531304348 -0.788537549 0 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Viral carcinogenesis 0 0.672924901 0.40952381 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Viral myocarditis 0 0.448616601 0.401029601 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Wnt signaling pathway 0 -0.856719368 -0.577863578 kegg kegg NA NA no no no no no no Lipid and atherosclerosis Yersinia infection 0.608695652 0.744071146 0.503217503 kegg kegg NA NA no no no no no no Long-term depression 2-Oxocarboxylic acid metabolism -0.482608696 0 -0.571428571 kegg kegg NA NA no no no no no no Long-term depression ABC transporters -0.726086957 0 0 kegg kegg NA NA no no no no up up Long-term depression Adrenergic signaling in cardiomyocytes 0.766086957 0.470355731 0.537451737 kegg kegg NA NA no no no no no up Long-term depression alpha-Linolenic acid metabolism -0.660869565 0 -0.647104247 kegg kegg NA NA no no no no no no Long-term depression Amino sugar and nucleotide sugar metabolism -0.645217391 0 -0.540540541 kegg kegg NA NA no no no no no no Long-term depression Aminoacyl-tRNA biosynthesis -0.670434783 -0.5 0 kegg kegg NA NA no no no no no no Long-term depression AMPK signaling pathway 0 0 0.446074646 kegg kegg NA NA no no no no no no Long-term depression Arginine and proline metabolism -0.44173913 0 0 kegg kegg NA NA no no no no up no Long-term depression Ascorbate and aldarate metabolism 0 0 -0.763706564 kegg kegg NA NA no no no no no no Long-term depression Bacteroides 0 -0.491106719 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Long-term depression Basal transcription factors 0 0 -0.406949807 kegg kegg NA NA no no no no no no Long-term depression Base excision repair -0.482608696 0 0 kegg kegg NA NA no no no no no no Long-term depression beta-Alanine metabolism -0.557391304 -0.59486166 -0.523809524 kegg kegg NA NA no no no no no no Long-term depression Biosynthesis of amino acids -0.457391304 0 0 kegg kegg NA NA no no no no no no Long-term depression Biosynthesis of cofactors 0 0 0.445045045 kegg kegg NA NA no no no no no no Long-term depression Biosynthesis of unsaturated fatty acids -0.515652174 -0.588932806 0 kegg kegg NA NA no no no no no no Long-term depression Butanoate metabolism -0.57826087 -0.52173913 -0.500643501 kegg kegg NA NA no no no no no no Long-term depression Butyricimonas 0.47822921 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Long-term depression Calcium signaling pathway 0.74173913 0.635375494 0.566795367 kegg kegg NA NA no no no no up up Long-term depression cAMP signaling pathway 0.597391304 0.719367589 0.675933076 yes kegg kegg NA NA no no no no up up Long-term depression Carbon metabolism -0.505217391 -0.577075099 0 kegg kegg NA NA no no no no no no Long-term depression Cardiac muscle contraction 0.587826087 0 0 kegg kegg NA NA no no no no no up Long-term depression Circadian entrainment 0.59826087 0 0.720978121 kegg kegg NA NA no no no no up up Long-term depression Citrate cycle (TCA cycle) -0.543478261 -0.597826087 -0.70965251 kegg kegg NA NA no no no no no no Long-term depression Clostridium 0 -0.530797652 0 kegg Genus NA 0.925 no no no no no no Long-term depression Cysteine and methionine metabolism -0.413913043 -0.528656126 0 kegg kegg NA NA no no no no no no Long-term depression DNA replication -0.51826087 0 -0.497554698 kegg kegg NA NA no no no no no no Long-term depression Dopaminergic synapse 0.67826087 0 0.603861004 kegg kegg NA NA no no no no up no Long-term depression Drug metabolism - cytochrome P450 0 0 -0.407722008 kegg kegg NA NA no no no no no no Long-term depression Drug metabolism - other enzymes -0.54 0 -0.624195624 kegg kegg NA NA no no no no no no Long-term depression Endocrine resistance 0.749565217 0.587944664 0.803346203 kegg kegg NA NA no no no no no no Long-term depression Ether lipid metabolism 0 0 -0.483655084 kegg kegg NA NA no no no no no no Long-term depression Fanconi anemia pathway -0.513913043 0 -0.454054054 kegg kegg NA NA no no no no no no Long-term depression Fatty acid degradation -0.659130435 0 -0.602316602 kegg kegg NA NA no no no no no no Long-term depression Fatty acid elongation -0.434782609 -0.593873518 -0.41981982 kegg kegg NA NA no no no no no no Long-term depression Fatty acid metabolism -0.664347826 -0.419960474 -0.47953668 kegg kegg NA NA no no no no no no Long-term depression Fc gamma R-mediated phagocytosis -0.446086957 0 0 kegg kegg NA NA no no no no no no Long-term depression Ferroptosis 0.575652174 0.652173913 0 kegg kegg NA NA no no no no no no Long-term depression Folate biosynthesis -0.450434783 0 0 kegg kegg NA NA no no no no no no Long-term depression Fructose and mannose metabolism -0.604347826 0 -0.514800515 kegg kegg NA NA no no no no no no Long-term depression Galactose metabolism -0.591304348 0 -0.61956242 kegg kegg NA NA no no no no no no Long-term depression Gap junction 0.735652174 0.882411067 0.832947233 kegg kegg NA NA no no no no no no Long-term depression Glutamatergic synapse 0.750434783 0.668972332 0.779407979 kegg kegg NA NA no no no no up up Long-term depression Glycerolipid metabolism -0.445217391 0 -0.483912484 kegg kegg NA NA no no no no no up Long-term depression Glycerophospholipid metabolism 0 0 -0.487516088 kegg kegg NA NA no no no no no up Long-term depression "Glycine, serine and threonine metabolism" 0 0 0.488030888 kegg kegg NA NA no no no no up no Long-term depression Glycolysis / Gluconeogenesis -0.52 -0.504940711 -0.417245817 kegg kegg NA NA no no no no no no Long-term depression Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.57992278 kegg kegg NA NA no no no no no no Long-term depression Glycosaminoglycan biosynthesis - keratan sulfate 0.624347826 0 0 kegg kegg NA NA no no no no no no Long-term depression Glycosaminoglycan degradation 0 0 -0.605662806 kegg kegg NA NA no no no no no up Long-term depression Glyoxylate and dicarboxylate metabolism -0.51826087 0 0 kegg kegg NA NA no no no no no no Long-term depression Hematopoietic cell lineage 0 -0.652173913 0 kegg kegg NA NA no no no no no no Long-term depression Hippo signaling pathway - multiple species 0 0 -0.420849421 kegg kegg NA NA no no no no no no Long-term depression Histidine metabolism -0.53826087 -0.501976285 -0.625740026 kegg kegg NA NA no no no no no no Long-term depression Homologous recombination -0.526086957 0 0 kegg kegg NA NA no no no no no no Long-term depression Inositol phosphate metabolism -0.455652174 0 -0.451222651 kegg kegg NA NA no no no no no no Long-term depression Long-term potentiation 0 -0.574110672 0 kegg kegg NA NA no no no no no up Long-term depression Longevity regulating pathway 0.504347826 0 0 kegg kegg NA NA no no no no no no Long-term depression Longevity regulating pathway - multiple species 0 -0.754940711 0 kegg kegg NA NA no no no no no no Long-term depression MAPK signaling pathway 0 -0.548418972 -0.416988417 kegg kegg NA NA no no no no no no Long-term depression Mismatch repair -0.580869565 -0.537549407 0 kegg kegg NA NA no no no no no no Long-term depression Mitophagy - animal 0.589565217 0 0 kegg kegg NA NA no no no no no no Long-term depression Mucin type O-glycan biosynthesis -0.479130435 -0.535573123 0 kegg kegg NA NA no no no no no no Long-term depression Necroptosis 0.634782609 0.595849802 0 kegg kegg NA NA no no no no no no Long-term depression NF-kappa B signaling pathway -0.47826087 0 0 kegg kegg NA NA no no no no no no Long-term depression Nicotinate and nicotinamide metabolism -0.413913043 0 0 kegg kegg NA NA no no no no no no Long-term depression NOD-like receptor signaling pathway -0.508695652 0 0 kegg kegg NA NA no no no no no no Long-term depression Non-homologous end-joining -0.568695652 -0.718379447 0 kegg kegg NA NA no no no no no no Long-term depression Notch signaling pathway 0 0 -0.44993565 kegg kegg NA NA no no no no no no Long-term depression Nucleotide excision repair -0.526956522 -0.425889328 0 kegg kegg NA NA no no no no no no Long-term depression Odoribacter -0.436302232 -0.504706847 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Long-term depression One carbon pool by folate 0 0 -0.419047619 kegg kegg NA NA no no no no no no Long-term depression Oocyte meiosis 0 -0.551383399 0 kegg kegg NA NA no no no no no no Long-term depression Osteoclast differentiation -0.428695652 0 0 kegg kegg NA NA no no no no no no Long-term depression Other glycan degradation -0.609565217 0 -0.496267696 kegg kegg NA NA no no no no no no Long-term depression Oxidative phosphorylation 0.536521739 0 0 kegg kegg NA NA no no no no no no Long-term depression Pantothenate and CoA biosynthesis 0 0 -0.415186615 kegg kegg NA NA no no no no no dn Long-term depression Pentose and glucuronate interconversions 0 0 -0.457657658 kegg kegg NA NA no no no no no no Long-term depression Peroxisome -0.635652174 0 0 kegg kegg NA NA no no no no no no Long-term depression Phenylalanine metabolism 0 -0.463438735 0 kegg kegg NA NA no no no no no no Long-term depression Phospholipase D signaling pathway 0.543478261 0.531620553 0.573487773 kegg kegg NA NA no no no no up up Long-term depression PI3K-Akt signaling pathway -0.457391304 0 0 yes kegg kegg NA NA no no no no up up Long-term depression Porphyrin and chlorophyll metabolism 0 0 0.445559846 kegg kegg NA NA no no no no no no Long-term depression Prevotella 0 0 0.462551243 acetate-producing kegg Genus NA 0.287 no no no no no no Long-term depression Primary bile acid biosynthesis -0.611304348 -0.713438735 0 kegg kegg NA NA no no no no no no Long-term depression Propanoate metabolism -0.546086957 -0.54743083 0 kegg kegg NA NA no no no no no no Long-term depression Proteasome 0 -0.542490119 -0.624710425 kegg kegg NA NA no no no no no no Long-term depression Pyrimidine metabolism -0.635652174 0 -0.417245817 kegg kegg NA NA no no no no no no Long-term depression Pyruvate metabolism -0.540869565 -0.425889328 0 kegg kegg NA NA no no no no no no Long-term depression Retinol metabolism -0.570434783 -0.41798419 -0.697812098 kegg kegg NA NA no no no no no no Long-term depression RNA polymerase 0 0 -0.46975547 kegg kegg NA NA no no no no no no Long-term depression RNA transport -0.526956522 0 0 kegg kegg NA NA no no no no no no Long-term depression Selenocompound metabolism 0 0 -0.555984556 kegg kegg NA NA no no no no no no Long-term depression Serotonergic synapse 0.456521739 0.60770751 0.732561133 kegg kegg NA NA no no no no no no Long-term depression SNARE interactions in vesicular transport -0.623478261 0 0 kegg kegg NA NA no no no no no no Long-term depression Sphingolipid metabolism 0 0 -0.525611326 kegg kegg NA NA no no no no no no Long-term depression Starch and sucrose metabolism -0.507826087 0 -0.53951094 kegg kegg NA NA no no no no no no Long-term depression Steroid biosynthesis 0 -0.570158103 0 kegg kegg NA NA no no no no no no Long-term depression Steroid hormone biosynthesis -0.448695652 -0.475296443 -0.697554698 kegg kegg NA NA no no no no no no Long-term depression Synaptic vesicle cycle 0 0 -0.419047619 kegg kegg NA NA no no no no up up Long-term depression Synthesis and degradation of ketone bodies -0.463478261 -0.580039526 0 kegg kegg NA NA no no no no no no Long-term depression Terpenoid backbone biosynthesis 0 -0.550395257 -0.488545689 kegg kegg NA NA no no no no no no Long-term depression Thermogenesis 0.585217391 0 0 kegg kegg NA NA no no no no no no Long-term depression Thiamine metabolism -0.529565217 0 0 kegg kegg NA NA no no no no no no Long-term depression Tryptophan metabolism -0.622608696 -0.672924901 -0.658429858 kegg kegg NA NA no no no no up no Long-term depression Ubiquinone and other terpenoid-quinone biosynthesis -0.613913043 -0.532608696 -0.441698842 kegg kegg NA NA no no no no no no Long-term depression Ubiquitin mediated proteolysis 0.571304348 0 0 kegg kegg NA NA no no no no no no Long-term depression "Valine, leucine and isoleucine degradation" -0.647826087 -0.519762846 -0.561389961 kegg kegg NA NA no no no no no no Long-term depression Vascular smooth muscle contraction 0.713043478 0 0.554440154 kegg kegg NA NA no no no no no no Long-term depression Wnt signaling pathway 0.493043478 0 0 kegg kegg NA NA no no no no no no Long-term potentiation 2-Oxocarboxylic acid metabolism -0.489565217 0 0 kegg kegg NA NA no no up no no no Long-term potentiation ABC transporters -0.407826087 0 0 kegg kegg NA NA no no up no up up Long-term potentiation Adherens junction -0.415652174 0 0 kegg kegg NA NA no no up no no no Long-term potentiation Adrenergic signaling in cardiomyocytes 0.623478261 0 0.541312741 kegg kegg NA NA no no up no no up Long-term potentiation "Alanine, aspartate and glutamate metabolism" 0 -0.431818182 -0.458944659 kegg kegg NA NA no no up no no no Long-term potentiation alpha-Linolenic acid metabolism -0.587826087 0 0 kegg kegg NA NA no no up no no no Long-term potentiation AMPK signaling pathway 0 0 -0.465379665 kegg kegg NA NA no no up no no no Long-term potentiation Apelin signaling pathway 0.45826087 0.688735178 0 kegg kegg NA NA no no up no no no Long-term potentiation Apoptosis -0.563478261 -0.648221344 -0.420849421 kegg kegg NA NA no no up no no no Long-term potentiation Arachidonic acid metabolism 0 0 -0.536936937 kegg kegg NA NA no no up no no no Long-term potentiation Arginine biosynthesis 0 -0.432806324 -0.518661519 kegg kegg NA NA no no up no no no Long-term potentiation Autophagy - animal 0 -0.454545455 0 kegg kegg NA NA no no up no no no Long-term potentiation Autophagy - other 0.570434783 0 0.695752896 kegg kegg NA NA no no up no no no Long-term potentiation Axon guidance 0.557391304 0 0.57014157 kegg kegg NA NA no no up no up up Long-term potentiation B cell receptor signaling pathway 0 -0.56027668 0 kegg kegg NA NA no no up no no no Long-term potentiation Bacteroides 0 0.588932806 0 LPS-producing kegg Genus NA 0.000267 no no up dn dn up Long-term potentiation Basal transcription factors 0.514782609 0.511857708 0.552895753 kegg kegg NA NA no no up no no no Long-term potentiation beta-Alanine metabolism -0.576521739 0.514822134 0 kegg kegg NA NA no no up no no no Long-term potentiation Biosynthesis of amino acids -0.53826087 0 -0.563706564 kegg kegg NA NA no no up no no no Long-term potentiation Biosynthesis of cofactors 0 0.479249012 -0.510939511 kegg kegg NA NA no no up no no no Long-term potentiation Biosynthesis of unsaturated fatty acids 0 0.57312253 0 kegg kegg NA NA no no up no no no Long-term potentiation Butanoate metabolism -0.42 0.706521739 0 kegg kegg NA NA no no up no no no Long-term potentiation C-type lectin receptor signaling pathway 0 -0.520750988 0 kegg kegg NA NA no no up no no no Long-term potentiation Calcium signaling pathway 0.553043478 0 0.447876448 kegg kegg NA NA no no up no up up Long-term potentiation cAMP signaling pathway 0.554782609 -0.602766798 0 yes kegg kegg NA NA no no up no up up Long-term potentiation Carbon metabolism -0.494782609 0 -0.425740026 kegg kegg NA NA no no up no no no Long-term potentiation Cell adhesion molecules -0.45826087 0 0 kegg kegg NA NA no no up no no no Long-term potentiation Cell cycle 0.62 0.459486166 0.675418275 kegg kegg NA NA no no up no no no Long-term potentiation Cellular senescence 0 -0.539525692 0 kegg kegg NA NA no no up no no no Long-term potentiation Chemokine signaling pathway 0 -0.505928854 0 kegg kegg NA NA no no up no no no Long-term potentiation Circadian rhythm 0.700869565 0 0.737451737 kegg kegg NA NA no no up no no no Long-term potentiation Citrate cycle (TCA cycle) 0 0.743083004 0 kegg kegg NA NA no no up no no no Long-term potentiation Clostridium 0 0.524684819 0 kegg Genus NA 0.925 no no up no no no Long-term potentiation Collinsella 0 0 -0.40004125 kegg Genus NA 0.128 no no up no no no Long-term potentiation Complement and coagulation cascades -0.465217391 0 -0.427284427 kegg kegg NA NA no no up no no no Long-term potentiation Cysteine and methionine metabolism 0 0.817193676 0 kegg kegg NA NA no no up no no no Long-term potentiation DNA replication 0 0.621541502 0 kegg kegg NA NA no no up no no no Long-term potentiation Drug metabolism - cytochrome P450 0 0.601778656 0 kegg kegg NA NA no no up no no no Long-term potentiation Drug metabolism - other enzymes 0 0.604743083 0 kegg kegg NA NA no no up no no no Long-term potentiation ECM-receptor interaction 0 0.551383399 0.427541828 kegg kegg NA NA no no up no up up Long-term potentiation EGFR tyrosine kinase inhibitor resistance 0 0.593873518 0 kegg kegg NA NA no no up no no no Long-term potentiation ErbB signaling pathway 0 -0.415019763 0.568339768 kegg kegg NA NA no no up no no no Long-term potentiation Fanconi anemia pathway 0 0 0.436550837 kegg kegg NA NA no no up no no no Long-term potentiation Fatty acid biosynthesis 0 -0.460474308 0 kegg kegg NA NA no no up no no no Long-term potentiation Fatty acid elongation 0 0.605731225 0 kegg kegg NA NA no no up no no no Long-term potentiation Fc epsilon RI signaling pathway 0 -0.605731225 0 kegg kegg NA NA no no up no no no Long-term potentiation Ferroptosis 0 -0.483201581 -0.481853282 kegg kegg NA NA no no up no no no Long-term potentiation Fructose and mannose metabolism -0.671304348 -0.567193676 -0.472844273 kegg kegg NA NA no no up no no no Long-term potentiation Galactose metabolism -0.68 0 0 kegg kegg NA NA no no up no no no Long-term potentiation Gap junction 0 -0.53458498 0 kegg kegg NA NA no no up no no no Long-term potentiation Glutathione metabolism 0 0 -0.506821107 kegg kegg NA NA no no up no no no Long-term potentiation Glycerolipid metabolism 0 -0.470355731 0 kegg kegg NA NA no no up no no up Long-term potentiation Glycerophospholipid metabolism 0 0 0.441441441 kegg kegg NA NA no no up no no up Long-term potentiation "Glycine, serine and threonine metabolism" 0 0 -0.513256113 kegg kegg NA NA no no up no up no Long-term potentiation Glycolysis / Gluconeogenesis 0 0.675889328 0 kegg kegg NA NA no no up no no no Long-term potentiation Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.7243083 0 kegg kegg NA NA no no up no no no Long-term potentiation Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.447619048 kegg kegg NA NA no no up no no no Long-term potentiation Glycosphingolipid biosynthesis - lacto and neolacto series 0 -0.596837945 0 kegg kegg NA NA no no up no no no Long-term potentiation Glyoxylate and dicarboxylate metabolism 0 0 -0.52972973 kegg kegg NA NA no no up no no no Long-term potentiation Hedgehog signaling pathway 0.45826087 0 0.56010296 kegg kegg NA NA no no up no no no Long-term potentiation Hematopoietic cell lineage 0 0.540513834 0 kegg kegg NA NA no no up no no no Long-term potentiation HIF-1 signaling pathway 0 0.611660079 0 kegg kegg NA NA no no up no no no Long-term potentiation JAK-STAT signaling pathway 0 -0.548418972 0 kegg kegg NA NA no no up no no no Long-term potentiation Longevity regulating pathway - multiple species 0 0.473320158 0 kegg kegg NA NA no no up no no no Long-term potentiation Lysine degradation 0 0 0.567567568 kegg kegg NA NA no no up no no no Long-term potentiation Mannose type O-glycan biosynthesis 0 0 0.595109395 kegg kegg NA NA no no up no no no Long-term potentiation MAPK signaling pathway 0 0 0.433462033 kegg kegg NA NA no no up no no no Long-term potentiation Metabolism of xenobiotics by cytochrome P450 0 0.615612648 0 kegg kegg NA NA no no up no no no Long-term potentiation Mismatch repair 0 0.743083004 0 kegg kegg NA NA no no up no no no Long-term potentiation mRNA surveillance pathway 0.506086957 0 0.680823681 kegg kegg NA NA no no up no no no Long-term potentiation mTOR signaling pathway 0 0.617588933 0 kegg kegg NA NA no no up no no no Long-term potentiation N-Glycan biosynthesis 0.494782609 0.499011858 0.41003861 kegg kegg NA NA no no up no no no Long-term potentiation Natural killer cell mediated cytotoxicity 0 -0.41798419 0 kegg kegg NA NA no no up no no no Long-term potentiation Necroptosis 0 0 -0.454568855 kegg kegg NA NA no no up no no no Long-term potentiation Neutrophil extracellular trap formation -0.44173913 0 -0.480823681 kegg kegg NA NA no no up no no no Long-term potentiation NF-kappa B signaling pathway 0 -0.628458498 0 kegg kegg NA NA no no up no no no Long-term potentiation Nicotinate and nicotinamide metabolism 0 -0.535573123 0 kegg kegg NA NA no no up no no no Long-term potentiation Non-homologous end-joining 0 0.761857708 0 kegg kegg NA NA no no up no no no Long-term potentiation Notch signaling pathway 0 -0.483201581 0.473873874 kegg kegg NA NA no no up no no no Long-term potentiation Nucleotide excision repair 0 0.64229249 0 kegg kegg NA NA no no up no no no Long-term potentiation One carbon pool by folate 0 0.489130435 0 kegg kegg NA NA no no up no no no Long-term potentiation Oocyte meiosis 0.809565217 0.904150198 0.791505792 kegg kegg NA NA no no up no no no Long-term potentiation Other types of O-glycan biosynthesis 0 0 0.534362934 kegg kegg NA NA no no up no no no Long-term potentiation p53 signaling pathway 0.439130435 0 0 kegg kegg NA NA no no up no no no Long-term potentiation Pentose and glucuronate interconversions 0 0.68972332 0 kegg kegg NA NA no no up no no no Long-term potentiation Pentose phosphate pathway -0.614782609 0 -0.561132561 kegg kegg NA NA no no up no no no Long-term potentiation Peroxisome 0 0 -0.542084942 kegg kegg NA NA no no up no no no Long-term potentiation Phagosome -0.542608696 0 0 kegg kegg NA NA no no up no no no Long-term potentiation Phenylalanine metabolism -0.46173913 0.501976285 0 kegg kegg NA NA no no up no no no Long-term potentiation Phosphatidylinositol signaling system 0.711304348 0 0.656628057 kegg kegg NA NA no no up no no no Long-term potentiation Phospholipase D signaling pathway 0 -0.813241107 0 kegg kegg NA NA no no up no up up Long-term potentiation PI3K-Akt signaling pathway 0 0 0.407207207 yes kegg kegg NA NA no no up no up up Long-term potentiation Platinum drug resistance 0.435652174 0 0 kegg kegg NA NA no no up no no no Long-term potentiation Porphyrin and chlorophyll metabolism 0 0 -0.530759331 kegg kegg NA NA no no up no no no Long-term potentiation Primary bile acid biosynthesis 0 0.748023715 0 kegg kegg NA NA no no up no no no Long-term potentiation Propanoate metabolism 0 0.798418972 0 kegg kegg NA NA no no up no no no Long-term potentiation Proteasome 0 0.664031621 0 kegg kegg NA NA no no up no no no Long-term potentiation Protein export 0.659130435 0.65513834 0.623938224 kegg kegg NA NA no no up no no no Long-term potentiation Protein processing in endoplasmic reticulum 0 0.528656126 0 kegg kegg NA NA no no up no no no Long-term potentiation Purine metabolism 0 0 -0.454826255 kegg kegg NA NA no no up no no no Long-term potentiation Pyrimidine metabolism 0 0.463438735 0 kegg kegg NA NA no no up no no no Long-term potentiation Pyruvate metabolism 0 0.7756917 0 kegg kegg NA NA no no up no no no Long-term potentiation Ras signaling pathway 0.642608696 0.568181818 0.761904762 yes kegg kegg NA NA no no up no up up Long-term potentiation Retinol metabolism 0 0.434782609 0 kegg kegg NA NA no no up no no no Long-term potentiation Ribosome 0.415652174 0.51284585 0 kegg kegg NA NA no no up no no no Long-term potentiation Ribosome biogenesis in eukaryotes 0.417391304 0.462450593 0.543114543 kegg kegg NA NA no no up no no no Long-term potentiation RIG-I-like receptor signaling pathway 0 -0.556324111 0 kegg kegg NA NA no no up no no no Long-term potentiation RNA degradation 0.504347826 0.472332016 0.722779923 kegg kegg NA NA no no up no no no Long-term potentiation RNA polymerase 0.495652174 0.517786561 0 kegg kegg NA NA no no up no no no Long-term potentiation RNA transport 0 0.668972332 0 kegg kegg NA NA no no up no no no Long-term potentiation Signaling pathways regulating pluripotency of stem cells 0.553043478 0 0.551093951 kegg kegg NA NA no no up no no no Long-term potentiation Sphingolipid signaling pathway 0.552173913 0 0.448906049 kegg kegg NA NA no no up no no no Long-term potentiation Spliceosome 0.406956522 0 0.688803089 kegg kegg NA NA no no up no no no Long-term potentiation Starch and sucrose metabolism -0.490434783 0 0 kegg kegg NA NA no no up no no no Long-term potentiation Steroid biosynthesis 0.460869565 0.678853755 0 kegg kegg NA NA no no up no no no Long-term potentiation Steroid hormone biosynthesis 0 0.593873518 0 kegg kegg NA NA no no up no no no Long-term potentiation Sulfur metabolism -0.406086957 0 -0.564736165 kegg kegg NA NA no no up no no no Long-term potentiation Synthesis and degradation of ketone bodies 0 0.674901186 0 kegg kegg NA NA no no up no no no Long-term potentiation T cell receptor signaling pathway 0 0 0.54002574 kegg kegg NA NA no no up no no no Long-term potentiation Taurine and hypotaurine metabolism 0 -0.5 0 kegg kegg NA NA no no up no no no Long-term potentiation Terpenoid backbone biosynthesis 0.443478261 0.539525692 0.44993565 kegg kegg NA NA no no up no no no Long-term potentiation TGF-beta signaling pathway 0.548695652 0.72826087 0.727670528 kegg kegg NA NA no no up no no no Long-term potentiation Thermogenesis 0 0.425889328 0 kegg kegg NA NA no no up no no no Long-term potentiation Thiamine metabolism 0 0.765810277 0 kegg kegg NA NA no no up no no no Long-term potentiation Tight junction -0.468695652 0 0 kegg kegg NA NA no no up no no no Long-term potentiation TNF signaling pathway 0 -0.633399209 0 kegg kegg NA NA no no up no no no Long-term potentiation Toll-like receptor signaling pathway 0 -0.602766798 0 yes kegg kegg NA NA no no up no no no Long-term potentiation Tryptophan metabolism 0 0.668972332 0 kegg kegg NA NA no no up no up no Long-term potentiation Tyrosine metabolism 0 0.636363636 0 kegg kegg NA NA no no up no no no Long-term potentiation Ubiquinone and other terpenoid-quinone biosynthesis 0 0.545454545 0 kegg kegg NA NA no no up no no no Long-term potentiation "Valine, leucine and isoleucine degradation" 0 0.62055336 0 kegg kegg NA NA no no up no no no Long-term potentiation Various types of N-glycan biosynthesis 0.588695652 0.479249012 0.465122265 kegg kegg NA NA no no up no no no Long-term potentiation Vascular smooth muscle contraction 0.422608696 0 0 kegg kegg NA NA no no up no no no Long-term potentiation VEGF signaling pathway 0.419130435 -0.494071146 0.621879022 kegg kegg NA NA no no up no no no Long-term potentiation Wnt signaling pathway 0 0.428853755 0.731788932 kegg kegg NA NA no no up no no no Longevity regulating pathway 2-Oxocarboxylic acid metabolism 0 0 -0.560875161 kegg kegg NA NA no no no no no no Longevity regulating pathway ABC transporters 0 0.473320158 0 kegg kegg NA NA no no no no up up Longevity regulating pathway Akkermansia 0 -0.420779509 0 acetate-producing kegg Genus NA 0.23 no no no no no no Longevity regulating pathway alpha-Linolenic acid metabolism -0.43826087 0 -0.547232947 kegg kegg NA NA no no no no no no Longevity regulating pathway Amino sugar and nucleotide sugar metabolism -0.483478261 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway AMPK signaling pathway 0.660869565 0.68083004 0.948519949 kegg kegg NA NA no no no no no no Longevity regulating pathway Ascorbate and aldarate metabolism -0.591304348 -0.449604743 0 kegg kegg NA NA no no no no no no Longevity regulating pathway beta-Alanine metabolism -0.450434783 -0.68083004 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Biosynthesis of cofactors 0 0.421936759 0.730759331 kegg kegg NA NA no no no no no no Longevity regulating pathway Biosynthesis of unsaturated fatty acids -0.620869565 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Calcium signaling pathway 0.503478261 0 0 kegg kegg NA NA no no no no up up Longevity regulating pathway Carbon metabolism -0.466086957 -0.703557312 0 kegg kegg NA NA no no no no no no Longevity regulating pathway cGMP-PKG signaling pathway 0 0 -0.448906049 kegg kegg NA NA no no no no no no Longevity regulating pathway Citrate cycle (TCA cycle) -0.555652174 0 -0.499099099 kegg kegg NA NA no no no no no no Longevity regulating pathway Clostridium 0 -0.593963591 0 kegg Genus NA 0.925 no no no no no no Longevity regulating pathway Cysteine and methionine metabolism -0.429565217 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Drug metabolism - cytochrome P450 -0.579130435 0 -0.470527671 kegg kegg NA NA no no no no no no Longevity regulating pathway Drug metabolism - other enzymes -0.508695652 0 -0.475160875 kegg kegg NA NA no no no no no no Longevity regulating pathway Endocrine resistance 0.580869565 0.445652174 0.453796654 kegg kegg NA NA no no no no no no Longevity regulating pathway Endocytosis 0 -0.420948617 0 kegg kegg NA NA no no no no no no Longevity regulating pathway ErbB signaling pathway 0.491304348 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Fatty acid elongation -0.669565217 -0.611660079 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Fatty acid metabolism -0.47826087 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Folate biosynthesis -0.415652174 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Galactose metabolism -0.44 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Glutathione metabolism 0 0 0.623938224 kegg kegg NA NA no no no no no no Longevity regulating pathway Glycerolipid metabolism 0 0 -0.435521236 kegg kegg NA NA no no no no no up Longevity regulating pathway Glycerophospholipid metabolism 0 0.528656126 0 kegg kegg NA NA no no no no no up Longevity regulating pathway "Glycine, serine and threonine metabolism" 0 0.543478261 0.785585586 kegg kegg NA NA no no no no up no Longevity regulating pathway Glycolysis / Gluconeogenesis -0.482608696 -0.574110672 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0 -0.436550837 kegg kegg NA NA no no no no no no Longevity regulating pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.56962677 kegg kegg NA NA no no no no no no Longevity regulating pathway Glycosaminoglycan biosynthesis - keratan sulfate 0.571304348 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Glycosaminoglycan degradation 0 0 -0.660746461 kegg kegg NA NA no no no no no up Longevity regulating pathway Glycosphingolipid biosynthesis - globo and isoglobo series 0 0 0.421364221 kegg kegg NA NA no no no no no no Longevity regulating pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.406086957 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.610671937 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Histidine metabolism -0.523478261 -0.415019763 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Mannose type O-glycan biosynthesis 0.49826087 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Metabolism of xenobiotics by cytochrome P450 -0.594782609 -0.514822134 -0.473873874 kegg kegg NA NA no no no no no no Longevity regulating pathway Mismatch repair -0.539130435 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Mitophagy - animal 0.582608696 0 0.701415701 kegg kegg NA NA no no no no no no Longevity regulating pathway Mucin type O-glycan biosynthesis -0.502608696 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Neuroactive ligand-receptor interaction -0.605217391 0 0 kegg kegg NA NA no no no up up up Longevity regulating pathway Nitrogen metabolism 0 0 0.407207207 kegg kegg NA NA no no no no no no Longevity regulating pathway Non-homologous end-joining -0.545217391 -0.540513834 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Other glycan degradation 0 0 -0.585070785 kegg kegg NA NA no no no no no no Longevity regulating pathway Other types of O-glycan biosynthesis 0 0.459486166 0 kegg kegg NA NA no no no no no no Longevity regulating pathway p53 signaling pathway 0.432173913 0.699604743 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Paraprevotella -0.556317234 0 0 kegg Genus NA 0.118 no no no no no no Longevity regulating pathway Pentose and glucuronate interconversions -0.685217391 0 -0.532303732 kegg kegg NA NA no no no no no no Longevity regulating pathway Phagosome 0 -0.499011858 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Phenylalanine metabolism -0.452173913 -0.553359684 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Phospholipase D signaling pathway 0.430434783 0 0 kegg kegg NA NA no no no no up up Longevity regulating pathway Porphyrin and chlorophyll metabolism 0 0.568181818 0.784555985 kegg kegg NA NA no no no no no no Longevity regulating pathway Primary bile acid biosynthesis -0.569565217 -0.454545455 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Propanoate metabolism -0.476521739 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Proteasome 0 0 -0.4002574 kegg kegg NA NA no no no no no no Longevity regulating pathway Protein processing in endoplasmic reticulum 0 0 0.471299871 kegg kegg NA NA no no no no no no Longevity regulating pathway Purine metabolism 0.531304348 0.565217391 0.709137709 kegg kegg NA NA no no no no no no Longevity regulating pathway Pyruvate metabolism -0.41826087 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Rap1 signaling pathway 0 -0.43972332 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Retinol metabolism -0.602608696 0 -0.442728443 kegg kegg NA NA no no no no no no Longevity regulating pathway SNARE interactions in vesicular transport 0 0 -0.498069498 kegg kegg NA NA no no no no no no Longevity regulating pathway Sphingolipid metabolism 0 0 -0.445045045 kegg kegg NA NA no no no no no no Longevity regulating pathway Sphingolipid signaling pathway 0 0 -0.48005148 kegg kegg NA NA no no no no no no Longevity regulating pathway Starch and sucrose metabolism -0.447826087 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Steroid hormone biosynthesis -0.586086957 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Sulfur metabolism 0 0 0.598970399 kegg kegg NA NA no no no no no no Longevity regulating pathway Synthesis and degradation of ketone bodies -0.484347826 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Taurine and hypotaurine metabolism 0 0.463438735 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Thiamine metabolism -0.419130435 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Tryptophan metabolism -0.460869565 -0.572134387 0 kegg kegg NA NA no no no no up no Longevity regulating pathway Tyrosine metabolism -0.453913043 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.476521739 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway Ubiquitin mediated proteolysis 0.56173913 0 0.68983269 kegg kegg NA NA no no no no no no Longevity regulating pathway "Valine, leucine and isoleucine degradation" -0.44173913 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species AMPK signaling pathway -0.431304348 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Bacteroides 0 0.466403162 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Longevity regulating pathway - multiple species beta-Alanine metabolism 0 0.566205534 0.61956242 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Biosynthesis of unsaturated fatty acids 0.523478261 0.707509881 0.636808237 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Blautia 0 0.583992095 0 acetate-producing kegg Genus NA 1.36E-05 no no no up dn dn Longevity regulating pathway - multiple species Butanoate metabolism 0 0.429841897 0.580694981 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Calcium signaling pathway 0 -0.729249012 -0.455083655 kegg kegg NA NA no no no no up up Longevity regulating pathway - multiple species cAMP signaling pathway 0 -0.585968379 -0.501415701 yes kegg kegg NA NA no no no no up up Longevity regulating pathway - multiple species Carbon metabolism 0 0.549407115 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Cell cycle 0.546086957 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Citrate cycle (TCA cycle) 0.465217391 0.442687747 0.42033462 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Cysteine and methionine metabolism 0.694782609 0.429841897 0.540797941 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Cytokine-cytokine receptor interaction 0 0.464426877 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species DNA replication 0.547826087 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Endocrine resistance 0 -0.618577075 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Fanconi anemia pathway 0.525217391 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Fatty acid degradation 0.54 0.438735178 0.466924067 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Fatty acid elongation 0 0.692687747 0.673616474 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Fatty acid metabolism 0.447826087 0.563241107 0.497554698 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species FoxO signaling pathway 0.596521739 0 0.515572716 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Glycolysis / Gluconeogenesis 0 0 0.533590734 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0 -0.451737452 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Glycosaminoglycan biosynthesis - keratan sulfate 0 -0.464426877 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 -0.584041184 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.406086957 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Histidine metabolism 0 0.447628458 0.44993565 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Homologous recombination 0.554782609 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Mannose type O-glycan biosynthesis -0.433043478 -0.429841897 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species MAPK signaling pathway 0.613913043 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Mismatch repair 0.625217391 0.454545455 0.541312741 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Mitophagy - animal -0.535652174 -0.494071146 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Mucin type O-glycan biosynthesis 0.626086957 0 0.46048906 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Neuroactive ligand-receptor interaction 0.502608696 0.461462451 0 kegg kegg NA NA no no no up up up Longevity regulating pathway - multiple species Non-homologous end-joining 0.44 0.671936759 0.726383526 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Nucleotide excision repair 0.582608696 0 0.477477477 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Odoribacter 0 0.435365377 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Longevity regulating pathway - multiple species One carbon pool by folate 0.588695652 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Oocyte meiosis 0.415652174 0.514822134 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Pantothenate and CoA biosynthesis 0.490434783 0 0 kegg kegg NA NA no no no no no dn Longevity regulating pathway - multiple species Pentose and glucuronate interconversions 0.452173913 0 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Peroxisome 0.509565217 0.434782609 0.501158301 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Phospholipase D signaling pathway 0 0 -0.477220077 kegg kegg NA NA no no no no up up Longevity regulating pathway - multiple species Primary bile acid biosynthesis 0.56173913 0.670948617 0.539253539 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Propanoate metabolism 0.692173913 0.436758893 0.558558559 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Pyruvate metabolism 0.672173913 0 0.602316602 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Retinol metabolism 0.619130435 0 0.439382239 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Steroid biosynthesis 0 0.498023715 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Steroid hormone biosynthesis 0 0.416996047 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Synthesis and degradation of ketone bodies 0.670434783 0.42687747 0.488288288 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Terpenoid backbone biosynthesis 0.590434783 0.551383399 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Tryptophan metabolism 0.426086957 0.588932806 0.575546976 kegg kegg NA NA no no no no up no Longevity regulating pathway - multiple species Tyrosine metabolism 0.456521739 0 0.692406692 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Ubiquinone and other terpenoid-quinone biosynthesis 0.409565217 0.429841897 0.41003861 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species Ubiquitin mediated proteolysis -0.513913043 -0.443675889 0 kegg kegg NA NA no no no no no no Longevity regulating pathway - multiple species "Valine, leucine and isoleucine degradation" 0.459130435 0 0.594851995 kegg kegg NA NA no no no no no no Lysine degradation "Alanine, aspartate and glutamate metabolism" 0 0 -0.563449163 kegg kegg NA NA no no no no no no Lysine degradation Arginine biosynthesis 0 0 -0.694980695 kegg kegg NA NA no no no no no no Lysine degradation Ascorbate and aldarate metabolism 0 0 0.542084942 kegg kegg NA NA no no no no no no Lysine degradation Citrate cycle (TCA cycle) 0 0 0.423680824 kegg kegg NA NA no no no no no no Lysine degradation Fructose and mannose metabolism 0 0.418972332 0 kegg kegg NA NA no no no no no no Lysine degradation "Glycine, serine and threonine metabolism" 0 0 -0.430630631 kegg kegg NA NA no no no no up no Lysine degradation Pentose and glucuronate interconversions 0 0 0.457657658 kegg kegg NA NA no no no no no no Lysine degradation Pentose phosphate pathway 0 -0.686758893 -0.611840412 kegg kegg NA NA no no no no no no Lysine degradation Steroid hormone biosynthesis 0 0 0.404375804 kegg kegg NA NA no no no no no no Lysine degradation Synthesis and degradation of ketone bodies 0 0 0.444015444 kegg kegg NA NA no no no no no no Lysine degradation Ubiquinone and other terpenoid-quinone biosynthesis 0 0 0.452509653 kegg kegg NA NA no no no no no no Lysosome 2-Oxocarboxylic acid metabolism 0 -0.433794466 0 kegg kegg NA NA no no no no no no Lysosome ABC transporters 0 -0.498023715 0 kegg kegg NA NA no no no no up up Lysosome "Alanine, aspartate and glutamate metabolism" 0.433913043 0.432806324 0.501415701 kegg kegg NA NA no no no no no no Lysosome alpha-Linolenic acid metabolism 0 0 0.432689833 kegg kegg NA NA no no no no no no Lysosome Aminoacyl-tRNA biosynthesis -0.533913043 -0.580039526 0 kegg kegg NA NA no no no no no no Lysosome Antifolate resistance -0.486086957 -0.707509881 0 kegg kegg NA NA no no no no no no Lysosome Arginine and proline metabolism 0.522608696 0.589920949 0.582239382 kegg kegg NA NA no no no no up no Lysosome Arginine biosynthesis 0.524347826 0.482213439 0.546718147 kegg kegg NA NA no no no no no no Lysosome Basal transcription factors -0.536521739 -0.698616601 -0.525611326 kegg kegg NA NA no no no no no no Lysosome Base excision repair -0.662608696 -0.766798419 -0.518918919 kegg kegg NA NA no no no no no no Lysosome Biosynthesis of amino acids 0 0.782608696 0.713770914 kegg kegg NA NA no no no no no no Lysosome Biosynthesis of cofactors -0.548695652 -0.696640316 0 kegg kegg NA NA no no no no no no Lysosome Calcium signaling pathway 0 0 -0.522265122 kegg kegg NA NA no no no no up up Lysosome Carbon metabolism 0 0.621541502 0.696010296 kegg kegg NA NA no no no no no no Lysosome Cell cycle -0.644347826 -0.855731225 -0.689060489 kegg kegg NA NA no no no no no no Lysosome cGMP-PKG signaling pathway 0.556521739 0.835968379 0.625482625 kegg kegg NA NA no no no no no no Lysosome Chemokine signaling pathway 0.429565217 0.60770751 0 kegg kegg NA NA no no no no no no Lysosome Clostridium 0 0.465594101 0 kegg Genus NA 0.925 no no no no no no Lysosome Coprococcus -0.471304348 0 0 butyrate-producing kegg Genus NA 0.612 no no no no no no Lysosome Cysteine and methionine metabolism -0.632173913 0 -0.607979408 kegg kegg NA NA no no no no no no Lysosome DNA replication -0.659130435 -0.633399209 -0.508365508 kegg kegg NA NA no no no no no no Lysosome EGFR tyrosine kinase inhibitor resistance -0.466956522 0 0 kegg kegg NA NA no no no no no no Lysosome Endocrine resistance 0 -0.630434783 0 kegg kegg NA NA no no no no no no Lysosome Ether lipid metabolism 0 -0.603754941 0 kegg kegg NA NA no no no no no no Lysosome Fanconi anemia pathway -0.696521739 -0.758893281 -0.535907336 kegg kegg NA NA no no no no no no Lysosome Fatty acid biosynthesis 0.463478261 0.506916996 0.478249678 kegg kegg NA NA no no no no no no Lysosome Fatty acid degradation 0 0 0.441184041 kegg kegg NA NA no no no no no no Lysosome Fatty acid metabolism 0 0.441699605 0.437065637 kegg kegg NA NA no no no no no no Lysosome Fructose and mannose metabolism 0 0 0.5997426 kegg kegg NA NA no no no no no no Lysosome Galactose metabolism 0 0 0.469240669 kegg kegg NA NA no no no no no no Lysosome Glutathione metabolism 0 -0.473320158 0 kegg kegg NA NA no no no no no no Lysosome Glycerophospholipid metabolism 0 -0.471343874 0 kegg kegg NA NA no no no no no up Lysosome "Glycine, serine and threonine metabolism" -0.462608696 -0.612648221 0 kegg kegg NA NA no no no no up no Lysosome Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.650434783 0 0.487258687 kegg kegg NA NA no no no no no no Lysosome Glycosaminoglycan biosynthesis - keratan sulfate 0 0 -0.400772201 kegg kegg NA NA no no no no no no Lysosome Glycosaminoglycan degradation 0.885217391 0.73715415 0.474903475 kegg kegg NA NA no no no no no up Lysosome Glycosphingolipid biosynthesis - ganglio series 0 -0.482213439 0 kegg kegg NA NA no no no no no no Lysosome Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.529565217 -0.731225296 0 kegg kegg NA NA no no no no no no Lysosome Glyoxylate and dicarboxylate metabolism 0.435652174 0.533596838 0.60978121 kegg kegg NA NA no no no no no no Lysosome HIF-1 signaling pathway -0.434782609 0 0 kegg kegg NA NA no no no no no no Lysosome Homologous recombination -0.623478261 -0.664031621 -0.588416988 kegg kegg NA NA no no no no no no Lysosome Inositol phosphate metabolism 0 -0.437747036 0 kegg kegg NA NA no no no no no no Lysosome Lysine degradation -0.44 -0.708498024 0 kegg kegg NA NA no no no no no no Lysosome Mannose type O-glycan biosynthesis 0 -0.562252964 0 kegg kegg NA NA no no no no no no Lysosome Mismatch repair -0.504347826 -0.515810277 -0.427027027 kegg kegg NA NA no no no no no no Lysosome Mitophagy - animal 0 -0.458498024 0 kegg kegg NA NA no no no no no no Lysosome mRNA surveillance pathway 0 -0.669960474 -0.58970399 kegg kegg NA NA no no no no no no Lysosome N-Glycan biosynthesis -0.660869565 -0.605731225 -0.603346203 kegg kegg NA NA no no no no no no Lysosome Neuroactive ligand-receptor interaction 0.469565217 0.846837945 0.788674389 kegg kegg NA NA no no no up up up Lysosome Nicotinate and nicotinamide metabolism 0.582608696 0.618577075 0.764736165 kegg kegg NA NA no no no no no no Lysosome Nitrogen metabolism 0.554782609 0.442687747 0 kegg kegg NA NA no no no no no no Lysosome Nucleotide excision repair -0.666956522 -0.698616601 -0.567052767 kegg kegg NA NA no no no no no no Lysosome One carbon pool by folate -0.74173913 -0.696640316 -0.491377091 kegg kegg NA NA no no no no no no Lysosome Oocyte meiosis -0.425217391 0 -0.564478764 kegg kegg NA NA no no no no no no Lysosome Other types of O-glycan biosynthesis -0.435652174 -0.802371542 -0.424453024 kegg kegg NA NA no no no no no no Lysosome p53 signaling pathway -0.42173913 -0.601778656 -0.441698842 kegg kegg NA NA no no no no no no Lysosome Pantothenate and CoA biosynthesis 0.488695652 0.612648221 0.748777349 kegg kegg NA NA no no no no no dn Lysosome Pentose and glucuronate interconversions 0 -0.479249012 0 kegg kegg NA NA no no no no no no Lysosome Pentose phosphate pathway 0.67826087 0.911067194 0.855598456 kegg kegg NA NA no no no no no no Lysosome Phosphatidylinositol signaling system 0 -0.581027668 -0.431402831 kegg kegg NA NA no no no no no no Lysosome Platinum drug resistance -0.528695652 -0.551383399 0 kegg kegg NA NA no no no no no no Lysosome Porphyrin and chlorophyll metabolism -0.431304348 -0.538537549 0 kegg kegg NA NA no no no no no no Lysosome PPAR signaling pathway 0.413913043 0.615612648 0.572715573 kegg kegg NA NA no no no no no no Lysosome Prevotella -0.523307137 0 0 acetate-producing kegg Genus NA 0.287 no no no no no no Lysosome Propanoate metabolism -0.497391304 0 -0.456885457 kegg kegg NA NA no no no no no no Lysosome Protein export -0.531304348 0 -0.418532819 kegg kegg NA NA no no no no no no Lysosome Protein processing in endoplasmic reticulum -0.629565217 -0.698616601 -0.51042471 kegg kegg NA NA no no no no no no Lysosome Purine metabolism 0 -0.707509881 0 kegg kegg NA NA no no no no no no Lysosome Pyramidobacter 0 0 -0.401484853 kegg Genus NA 0.45 no no no no no no Lysosome Pyrimidine metabolism 0 -0.571146245 0 kegg kegg NA NA no no no no no no Lysosome Pyruvate metabolism -0.6 -0.43083004 -0.417503218 kegg kegg NA NA no no no no no no Lysosome Retinol metabolism 0 -0.48715415 0 kegg kegg NA NA no no no no no no Lysosome Ribosome biogenesis in eukaryotes -0.772173913 -0.836956522 -0.613384813 kegg kegg NA NA no no no no no no Lysosome RNA degradation 0 -0.617588933 -0.513770914 kegg kegg NA NA no no no no no no Lysosome RNA polymerase -0.708695652 -0.845849802 -0.491891892 kegg kegg NA NA no no no no no no Lysosome RNA transport -0.555652174 0 -0.47001287 kegg kegg NA NA no no no no no no Lysosome Ruminococcus -0.483478261 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Lysosome Selenocompound metabolism -0.411304348 -0.641304348 0 kegg kegg NA NA no no no no no no Lysosome Sphingolipid metabolism 0.873913043 0.445652174 0.589446589 kegg kegg NA NA no no no no no no Lysosome Sphingolipid signaling pathway 0.405217391 0.660079051 0 kegg kegg NA NA no no no no no no Lysosome Spliceosome -0.655652174 -0.660079051 -0.601801802 kegg kegg NA NA no no no no no no Lysosome Starch and sucrose metabolism 0.459130435 0.507905138 0.764478764 kegg kegg NA NA no no no no no no Lysosome Steroid biosynthesis -0.530434783 0 0 kegg kegg NA NA no no no no no no Lysosome Synthesis and degradation of ketone bodies -0.553043478 -0.563241107 0 kegg kegg NA NA no no no no no no Lysosome Terpenoid backbone biosynthesis -0.483478261 0 -0.411325611 kegg kegg NA NA no no no no no no Lysosome Tyrosine metabolism -0.409565217 -0.421936759 0 kegg kegg NA NA no no no no no no Lysosome Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.466403162 -0.445559846 kegg kegg NA NA no no no no no no Lysosome Ubiquitin mediated proteolysis 0 -0.578063241 0 kegg kegg NA NA no no no no no no Lysosome "Valine, leucine and isoleucine degradation" -0.457391304 0 0 kegg kegg NA NA no no no no no no Lysosome Various types of N-glycan biosynthesis -0.528695652 -0.514822134 -0.429086229 kegg kegg NA NA no no no no no no Lysosome Viral protein interaction with cytokine and cytokine receptor 0 0.496047431 0 kegg kegg NA NA no no no no no no Malaria 2-Oxocarboxylic acid metabolism 0 -0.633399209 -0.423423423 kegg kegg NA NA no no no no no no Malaria Adipocytokine signaling pathway 0.46173913 0.720355731 0.663577864 kegg kegg NA NA no no no no no no Malaria Aldosterone-regulated sodium reabsorption 0 0 -0.486229086 kegg kegg NA NA no no no no no no Malaria alpha-Linolenic acid metabolism 0 0 -0.414929215 kegg kegg NA NA no no no no no no Malaria Aminoacyl-tRNA biosynthesis 0 -0.508893281 0 kegg kegg NA NA no no no no no no Malaria AMPK signaling pathway 0.559130435 0.423913043 0.687001287 kegg kegg NA NA no no no no no no Malaria Arachidonic acid metabolism 0.533913043 0 0.453024453 kegg kegg NA NA no no no no no no Malaria Arginine biosynthesis 0 0.473320158 0 kegg kegg NA NA no no no no no no Malaria Ascorbate and aldarate metabolism 0 -0.564229249 0 kegg kegg NA NA no no no no no no Malaria Bacterial invasion of epithelial cells 0 -0.493083004 0 kegg kegg NA NA no no no no no no Malaria beta-Alanine metabolism 0 -0.659090909 0 kegg kegg NA NA no no no no no no Malaria Bile secretion 0 0 0.566023166 kegg kegg NA NA no no no no no no Malaria Biosynthesis of cofactors 0 0 0.58043758 kegg kegg NA NA no no no no no no Malaria Biosynthesis of unsaturated fatty acids 0 -0.41798419 0 kegg kegg NA NA no no no no no no Malaria Butanoate metabolism 0 -0.576086957 0 kegg kegg NA NA no no no no no no Malaria cAMP signaling pathway 0 0.589920949 0 yes kegg kegg NA NA no no no no up up Malaria Carbohydrate digestion and absorption 0 0 -0.564993565 kegg kegg NA NA no no no no no no Malaria Carbon metabolism 0 -0.497035573 0 kegg kegg NA NA no no no no no no Malaria Cell cycle -0.444347826 0 0 kegg kegg NA NA no no no no no no Malaria Chagas disease 0 0.591897233 0 kegg kegg NA NA no no no no no no Malaria Cholinergic synapse 0 0 -0.545688546 kegg kegg NA NA no no no no no no Malaria Citrate cycle (TCA cycle) 0 -0.557312253 0 kegg kegg NA NA no no no no no no Malaria Cocaine addiction 0 0.486166008 0 kegg kegg NA NA no no no no no no Malaria Collecting duct acid secretion 0 0 0.40952381 kegg kegg NA NA no no no no no no Malaria Cytosolic DNA-sensing pathway 0 0.541501976 0 kegg kegg NA NA no no no no no no Malaria DNA replication 0 -0.495059289 0 kegg kegg NA NA no no no no no no Malaria Drug metabolism - cytochrome P450 0 -0.520750988 0 kegg kegg NA NA no no no no no no Malaria Drug metabolism - other enzymes 0 -0.526679842 0 kegg kegg NA NA no no no no no no Malaria ErbB signaling pathway 0 0 -0.61003861 kegg kegg NA NA no no no no no no Malaria Estrogen signaling pathway 0 -0.468379447 0 kegg kegg NA NA no no no no no no Malaria Fanconi anemia pathway -0.407826087 0 0 kegg kegg NA NA no no no no no no Malaria Fatty acid elongation 0 -0.518774704 0 kegg kegg NA NA no no no no no no Malaria Fc epsilon RI signaling pathway 0 0 -0.43011583 kegg kegg NA NA no no no no no no Malaria Ferroptosis 0.686956522 0.743083004 0.84967825 kegg kegg NA NA no no no no no no Malaria Focal adhesion 0 -0.51284585 -0.452252252 kegg kegg NA NA no no no no up up Malaria Folate biosynthesis -0.603478261 -0.466403162 0 kegg kegg NA NA no no no no no no Malaria GABAergic synapse 0 0.43972332 0 kegg kegg NA NA no no no no up up Malaria Gap junction 0 0.468379447 0 kegg kegg NA NA no no no no no no Malaria Glutamatergic synapse 0.446086957 0.511857708 0.455083655 kegg kegg NA NA no no no no up up Malaria Glutathione metabolism 0.61826087 0 0.611068211 kegg kegg NA NA no no no no no no Malaria Glycerolipid metabolism 0 0 -0.580694981 kegg kegg NA NA no no no no no up Malaria Glycerophospholipid metabolism 0 0 -0.491377091 kegg kegg NA NA no no no no no up Malaria "Glycine, serine and threonine metabolism" 0 0 0.582754183 kegg kegg NA NA no no no no up no Malaria Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0 -0.426512227 kegg kegg NA NA no no no no no no Malaria Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.622529644 -0.549034749 kegg kegg NA NA no no no no no no Malaria Glycosaminoglycan degradation 0 0 -0.606692407 kegg kegg NA NA no no no no no up Malaria Glycosphingolipid biosynthesis - ganglio series 0 -0.506916996 0 kegg kegg NA NA no no no no no no Malaria Glyoxylate and dicarboxylate metabolism 0 0.456521739 0 kegg kegg NA NA no no no no no no Malaria GnRH secretion 0 0 -0.547490347 kegg kegg NA NA no no no no up up Malaria Hedgehog signaling pathway 0 0 -0.500643501 kegg kegg NA NA no no no no no no Malaria Hematopoietic cell lineage 0 -0.756916996 0 kegg kegg NA NA no no no no no no Malaria Hippo signaling pathway 0 -0.51284585 -0.438610039 kegg kegg NA NA no no no no no no Malaria Hippo signaling pathway - multiple species 0 0 -0.564736165 kegg kegg NA NA no no no no no no Malaria Histidine metabolism 0 -0.43972332 0 kegg kegg NA NA no no no no no no Malaria Homologous recombination -0.446086957 0 0 kegg kegg NA NA no no no no no no Malaria Inositol phosphate metabolism -0.490434783 0 -0.556241956 kegg kegg NA NA no no no no no no Malaria JAK-STAT signaling pathway -0.463478261 0 0 kegg kegg NA NA no no no no no no Malaria Long-term depression 0 0.494071146 0 kegg kegg NA NA no no no no no no Malaria Longevity regulating pathway 0.47826087 0.60770751 0.678764479 kegg kegg NA NA no no no no no no Malaria Lysine degradation 0 0 -0.494208494 kegg kegg NA NA no no no no no no Malaria Mannose type O-glycan biosynthesis 0 0 -0.49034749 kegg kegg NA NA no no no no no no Malaria MAPK signaling pathway -0.529565217 0 -0.532046332 kegg kegg NA NA no no no no no no Malaria Metabolism of xenobiotics by cytochrome P450 0 -0.612648221 0 kegg kegg NA NA no no no no no no Malaria Mineral absorption 0.626086957 0.625494071 0.845559846 kegg kegg NA NA no no no no no no Malaria Mitophagy - animal 0.453913043 0.460474308 0.94002574 kegg kegg NA NA no no no no no no Malaria N-Glycan biosynthesis 0 -0.466403162 -0.433719434 kegg kegg NA NA no no no no no no Malaria Necroptosis 0.646086957 0.772727273 0.858429858 kegg kegg NA NA no no no no no no Malaria NF-kappa B signaling pathway -0.410434783 0 0 kegg kegg NA NA no no no no no no Malaria Nitrogen metabolism 0 0.597826087 0.428314028 kegg kegg NA NA no no no no no no Malaria Non-homologous end-joining 0 -0.500988142 0 kegg kegg NA NA no no no no no no Malaria Notch signaling pathway 0 0 -0.611583012 kegg kegg NA NA no no no no no no Malaria One carbon pool by folate 0 -0.519762846 0 kegg kegg NA NA no no no no no no Malaria Oocyte meiosis 0 -0.443675889 0 kegg kegg NA NA no no no no no no Malaria Other glycan degradation 0 0 -0.680823681 kegg kegg NA NA no no no no no no Malaria Other types of O-glycan biosynthesis -0.406956522 0 -0.493436293 kegg kegg NA NA no no no no no no Malaria Ovarian steroidogenesis 0 0.443675889 0.446589447 kegg kegg NA NA no no no no up up Malaria "Parathyroid hormone synthesis, secretion and action" 0 0 0.471557272 kegg kegg NA NA no no no no no no Malaria Parkinson disease 0 0 0.764221364 kegg kegg NA NA no no no no no no Malaria Pathways of neurodegeneration - multiple diseases 0 0 0.755469755 kegg kegg NA NA no no no no no no Malaria Pentose and glucuronate interconversions 0 -0.555335968 0 kegg kegg NA NA no no no no no no Malaria Peroxisome 0 0 0.432947233 kegg kegg NA NA no no no no no no Malaria Phenylalanine metabolism 0 -0.636363636 0 kegg kegg NA NA no no no no no no Malaria Phosphatidylinositol signaling system 0 -0.457509881 -0.521235521 kegg kegg NA NA no no no no no no Malaria Porphyrin and chlorophyll metabolism 0.543478261 0 0.673873874 kegg kegg NA NA no no no no no no Malaria Primary bile acid biosynthesis 0 -0.460474308 0 kegg kegg NA NA no no no no no no Malaria Progesterone-mediated oocyte maturation -0.480869565 0 -0.526383526 kegg kegg NA NA no no no no no no Malaria Proteasome 0 -0.462450593 0 kegg kegg NA NA no no no no no no Malaria Protein processing in endoplasmic reticulum 0 0 0.647361647 kegg kegg NA NA no no no no no no Malaria Proximal tubule bicarbonate reclamation 0 -0.457509881 0 kegg kegg NA NA no no no no no no Malaria Purine metabolism 0.731304348 0 0.842213642 kegg kegg NA NA no no no no no no Malaria Pyrimidine metabolism 0 -0.467391304 0 kegg kegg NA NA no no no no no no Malaria Ras signaling pathway 0 -0.476284585 0 yes kegg kegg NA NA no no no no up up Malaria Regulation of lipolysis in adipocytes 0 0.41798419 0 kegg kegg NA NA no no no no no no Malaria Relaxin signaling pathway 0 0.601778656 0 kegg kegg NA NA no no no no no no Malaria Renin secretion 0 0 0.425740026 kegg kegg NA NA no no no no no no Malaria Retinol metabolism 0 -0.51284585 0 kegg kegg NA NA no no no no no no Malaria Ribosome 0 0 0.411325611 kegg kegg NA NA no no no no no no Malaria RIG-I-like receptor signaling pathway 0 0.432806324 0 kegg kegg NA NA no no no no no no Malaria RNA degradation 0 0 -0.442213642 kegg kegg NA NA no no no no no no Malaria Roseburia 0.414782609 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no Malaria Shigellosis 0.422608696 0.500988142 0.927413127 kegg kegg NA NA no no no no no no Malaria Signaling pathways regulating pluripotency of stem cells 0 0 -0.469498069 kegg kegg NA NA no no no no no no Malaria SNARE interactions in vesicular transport -0.420869565 0 0 kegg kegg NA NA no no no no no no Malaria Sphingolipid metabolism 0 0 -0.504247104 kegg kegg NA NA no no no no no no Malaria Sphingolipid signaling pathway 0 0 -0.676705277 kegg kegg NA NA no no no no no no Malaria Spinocerebellar ataxia 0 0 -0.436550837 kegg kegg NA NA no no no no no no Malaria Steroid biosynthesis 0 -0.500988142 0 kegg kegg NA NA no no no no no no Malaria Steroid hormone biosynthesis 0 -0.599802372 0 kegg kegg NA NA no no no no no no Malaria Sulfur metabolism 0.483478261 0 0.596911197 kegg kegg NA NA no no no no no no Malaria Synthesis and degradation of ketone bodies 0 -0.429841897 0 kegg kegg NA NA no no no no no no Malaria T cell receptor signaling pathway -0.605217391 0 0 kegg kegg NA NA no no no no no no Malaria Taste transduction -0.44173913 0 -0.537966538 kegg kegg NA NA no no no no no up Malaria TGF-beta signaling pathway 0 0 -0.434491634 kegg kegg NA NA no no no no no no Malaria Th1 and Th2 cell differentiation 0 0 -0.491119691 kegg kegg NA NA no no no no no no Malaria Th17 cell differentiation 0 0 -0.446589447 kegg kegg NA NA no no no no no no Malaria Thyroid hormone signaling pathway 0 0 -0.506306306 kegg kegg NA NA no no no no no no Malaria Thyroid hormone synthesis 0.507826087 0 0.540540541 kegg kegg NA NA no no no no no no Malaria Tryptophan metabolism 0 -0.708498024 0 kegg kegg NA NA no no no no up no Malaria Type II diabetes mellitus 0 0 -0.456628057 kegg kegg NA NA no no no no no no Malaria Tyrosine metabolism 0 -0.489130435 0 kegg kegg NA NA no no no no no no Malaria Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.540513834 0 kegg kegg NA NA no no no no no no Malaria Ubiquitin mediated proteolysis 0 0 0.927413127 kegg kegg NA NA no no no no no no Malaria "Valine, leucine and isoleucine degradation" 0 -0.615612648 0 kegg kegg NA NA no no no no no no Malaria Various types of N-glycan biosynthesis 0 -0.531620553 -0.536936937 kegg kegg NA NA no no no no no no Malaria VEGF signaling pathway 0 0 -0.613384813 kegg kegg NA NA no no no no no no Malaria Vitamin digestion and absorption 0 0 -0.452252252 kegg kegg NA NA no no no no no no Malaria Wnt signaling pathway 0 0 -0.554182754 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis "Alanine, aspartate and glutamate metabolism" 0 0 -0.631917632 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Arginine and proline metabolism -0.517391304 0 0 kegg kegg NA NA no no no no up no Mannose type O-glycan biosynthesis Arginine biosynthesis 0 0 -0.725611326 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis beta-Alanine metabolism -0.51826087 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Cysteine and methionine metabolism -0.444347826 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Fatty acid degradation -0.533913043 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Fatty acid elongation -0.527826087 -0.492094862 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Fructose and mannose metabolism -0.451304348 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Galactose metabolism -0.46 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Glutathione metabolism 0 0 -0.481853282 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Glycolysis / Gluconeogenesis -0.670434783 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Histidine metabolism -0.434782609 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Lysine degradation 0.646956522 0.897233202 0.904504505 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Mucin type O-glycan biosynthesis -0.542608696 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis N-Glycan biosynthesis 0 0.462450593 0.594851995 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Other glycan degradation 0 0.630434783 0.607207207 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Other types of O-glycan biosynthesis 0.579130435 0.791501976 0.862548263 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Oxidative phosphorylation 0.42173913 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Pentose and glucuronate interconversions -0.437391304 0 0.484427284 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Pentose phosphate pathway 0 -0.587944664 -0.61956242 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Primary bile acid biosynthesis -0.476521739 -0.472332016 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Pyrimidine metabolism -0.62173913 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Selenocompound metabolism 0 0.508893281 0.656885457 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Starch and sucrose metabolism -0.507826087 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Steroid hormone biosynthesis -0.632173913 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Taurine and hypotaurine metabolism 0 0.56027668 0.593564994 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Tryptophan metabolism -0.426956522 0 0 kegg kegg NA NA no no no no up no Mannose type O-glycan biosynthesis Tyrosine metabolism -0.613043478 0 0 kegg kegg NA NA no no no no no no Mannose type O-glycan biosynthesis Various types of N-glycan biosynthesis 0 0.548418972 0.555984556 kegg kegg NA NA no no no no no no MAPK signaling pathway ABC transporters 0 0.550395257 0 kegg kegg NA NA no no no no up up MAPK signaling pathway "Alanine, aspartate and glutamate metabolism" 0 0.445652174 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Alistipes -0.627953586 0.453196041 0 kegg Genus NA 0.0114 no no no no up no MAPK signaling pathway alpha-Linolenic acid metabolism 0 0.524703557 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Amino sugar and nucleotide sugar metabolism 0 0.561264822 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Aminoacyl-tRNA biosynthesis 0 0.501976285 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Arachidonic acid metabolism 0 0 -0.575546976 kegg kegg NA NA no no no no no no MAPK signaling pathway Base excision repair 0.41826087 0.450592885 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Biosynthesis of cofactors 0 0 -0.446589447 kegg kegg NA NA no no no no no no MAPK signaling pathway Collinsella 0 0 -0.577605251 kegg Genus NA 0.128 no no no no no no MAPK signaling pathway Fanconi anemia pathway 0.45826087 0.559288538 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Fatty acid biosynthesis 0 0.45256917 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Fatty acid degradation 0.426086957 0.710474308 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Fatty acid metabolism 0 0.588932806 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Folate biosynthesis 0.429565217 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Fructose and mannose metabolism 0 0.500988142 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Galactose metabolism 0 0.583992095 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Glutathione metabolism -0.56 0 -0.615958816 kegg kegg NA NA no no no no no no MAPK signaling pathway Glycerolipid metabolism 0 0.66798419 0.470785071 kegg kegg NA NA no no no no no up MAPK signaling pathway Glycerophospholipid metabolism 0 0.637351779 0.446589447 kegg kegg NA NA no no no no no up MAPK signaling pathway "Glycine, serine and threonine metabolism" 0 0 -0.407979408 kegg kegg NA NA no no no no up no MAPK signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.42687747 0.451480051 kegg kegg NA NA no no no no no no MAPK signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.532818533 kegg kegg NA NA no no no no no no MAPK signaling pathway Glycosaminoglycan degradation 0 0 0.407979408 kegg kegg NA NA no no no no no up MAPK signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.548695652 0 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Histidine metabolism 0 0.471343874 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Homologous recombination 0.589565217 0.631422925 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Inositol phosphate metabolism 0.562608696 0.776679842 0.519433719 kegg kegg NA NA no no no no no no MAPK signaling pathway Lysine degradation 0 0.490118577 0.464864865 kegg kegg NA NA no no no no no no MAPK signaling pathway Mannose type O-glycan biosynthesis 0 0 0.400772201 kegg kegg NA NA no no no no no no MAPK signaling pathway Mucin type O-glycan biosynthesis 0.491304348 0.754940711 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Oscillospira 0 0.579051383 0 LPS-producing kegg Genus NA 0.62 no no no no no no MAPK signaling pathway Other glycan degradation 0 0.571146245 0.411325611 kegg kegg NA NA no no no no no no MAPK signaling pathway Other types of O-glycan biosynthesis 0 0.449604743 0.429343629 kegg kegg NA NA no no no no no no MAPK signaling pathway Oxidative phosphorylation 0 -0.695652174 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Pantothenate and CoA biosynthesis 0.49826087 0 0 kegg kegg NA NA no no no no no dn MAPK signaling pathway Parabacteroides 0 0.46541502 0 kegg Genus NA 4.19E-05 no no no no up up MAPK signaling pathway Platinum drug resistance 0.50173913 0.695652174 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Porphyrin and chlorophyll metabolism 0 0 -0.466666667 kegg kegg NA NA no no no no no no MAPK signaling pathway Protein export 0 -0.447628458 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Ribosome 0 -0.561264822 0 kegg kegg NA NA no no no no no no MAPK signaling pathway RNA degradation 0 0 0.432175032 kegg kegg NA NA no no no no no no MAPK signaling pathway Selenocompound metabolism 0.45826087 0.679841897 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Spliceosome 0 0.618577075 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Starch and sucrose metabolism 0 0.481225296 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Sulfur metabolism 0 0 -0.410810811 kegg kegg NA NA no no no no no no MAPK signaling pathway Taurine and hypotaurine metabolism 0 0.472332016 0 kegg kegg NA NA no no no no no no MAPK signaling pathway Terpenoid backbone biosynthesis 0.55826087 0 0 kegg kegg NA NA no no no no no no Maturity onset diabetes of the young ABC transporters 0 0 0.60952381 kegg kegg NA NA no up no no up up Maturity onset diabetes of the young Amino sugar and nucleotide sugar metabolism -0.42 0 0.426769627 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young AMPK signaling pathway 0 0 -0.441956242 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Antifolate resistance 0 0 0.493693694 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Ascorbate and aldarate metabolism 0 0.504940711 0.458172458 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Biosynthesis of amino acids -0.489565217 -0.422924901 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Carbon metabolism -0.522608696 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Cell adhesion molecules 0 -0.584980237 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Cellular senescence 0 -0.603754941 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Cholinergic synapse 0 0 0.545688546 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Circadian entrainment 0 0.509881423 0 kegg kegg NA NA no up no no up up Maturity onset diabetes of the young Complement and coagulation cascades -0.443478261 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Cortisol synthesis and secretion 0 0.425889328 0 kegg kegg NA NA no up no no no up Maturity onset diabetes of the young Cushing syndrome 0 0.423913043 0 kegg kegg NA NA no up no no no up Maturity onset diabetes of the young Cysteine and methionine metabolism -0.511304348 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Cytokine-cytokine receptor interaction -0.431304348 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Dopaminergic synapse 0 0.477272727 0 kegg kegg NA NA no up no no up no Maturity onset diabetes of the young Drug metabolism - cytochrome P450 -0.453913043 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Drug metabolism - other enzymes 0 0 0.522265122 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Endocrine resistance 0 0.440711462 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Endocytosis 0 -0.599802372 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Estrogen signaling pathway -0.471304348 0.468379447 -0.483397683 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Ether lipid metabolism 0.474782609 0.59486166 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Fatty acid elongation -0.412173913 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Fc gamma R-mediated phagocytosis 0 0 -0.417760618 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Focal adhesion -0.45826087 0 0 kegg kegg NA NA no up no no up up Maturity onset diabetes of the young Galactose metabolism 0 0 0.583526384 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Gap junction 0 0 -0.567567568 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Glutamatergic synapse 0 0 -0.443500644 kegg kegg NA NA no up no no up up Maturity onset diabetes of the young Glycerolipid metabolism 0 0 0.546718147 kegg kegg NA NA no up no no no up Maturity onset diabetes of the young Glycerophospholipid metabolism 0.594782609 0 0.583268983 kegg kegg NA NA no up no no no up Maturity onset diabetes of the young Glycolysis / Gluconeogenesis -0.655652174 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.451737452 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Glycosaminoglycan degradation 0 0 0.472586873 kegg kegg NA NA no up no no no up Maturity onset diabetes of the young Glycosphingolipid biosynthesis - ganglio series 0.408695652 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Glycosphingolipid biosynthesis - lacto and neolacto series 0.617391304 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young GnRH secretion 0 0 0.421621622 kegg kegg NA NA no up no no up up Maturity onset diabetes of the young Hedgehog signaling pathway 0.508695652 0 0.55984556 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Hippo signaling pathway - multiple species 0 0 0.517889318 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Inositol phosphate metabolism 0 0 0.569111969 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Leukocyte transendothelial migration -0.453043478 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Longevity regulating pathway 0.550434783 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Lysine degradation 0 0 0.552123552 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Mannose type O-glycan biosynthesis 0.464347826 0 0.577606178 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Metabolism of xenobiotics by cytochrome P450 -0.426956522 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young mRNA surveillance pathway 0.503478261 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Mucin type O-glycan biosynthesis -0.513043478 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Natural killer cell mediated cytotoxicity -0.489565217 -0.625494071 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Neuroactive ligand-receptor interaction -0.449565217 0 0 kegg kegg NA NA no up no up up up Maturity onset diabetes of the young Neurotrophin signaling pathway 0 -0.453557312 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Non-homologous end-joining -0.476521739 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Notch signaling pathway 0.728695652 0 0.72046332 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young One carbon pool by folate 0 0 0.451222651 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Other glycan degradation 0 0 0.578635779 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Other types of O-glycan biosynthesis 0 0 0.589446589 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Ovarian steroidogenesis 0 0 -0.446074646 kegg kegg NA NA no up no no up up Maturity onset diabetes of the young p53 signaling pathway 0.507826087 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Pentose and glucuronate interconversions -0.520869565 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Phagosome 0 -0.524703557 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Phosphatidylinositol signaling system 0.483478261 0 0.501158301 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Propanoate metabolism -0.540869565 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Pyrimidine metabolism 0 0 0.662290862 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Regulation of actin cytoskeleton -0.613043478 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Regulation of lipolysis in adipocytes 0 0 -0.420849421 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Renin secretion 0 0 -0.441184041 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Retinol metabolism -0.533043478 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young RNA degradation 0.486086957 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young RNA transport -0.49826087 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Selenocompound metabolism 0 0 0.557786358 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Serotonergic synapse 0 0 -0.469498069 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young SNARE interactions in vesicular transport 0 0 0.528700129 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Sphingolipid metabolism 0 0 0.497297297 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Sphingolipid signaling pathway 0 -0.480237154 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Starch and sucrose metabolism 0 0 0.443758044 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Steroid hormone biosynthesis 0 0.532608696 0.458429858 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young T cell receptor signaling pathway -0.414782609 -0.505928854 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Taste transduction 0 0 0.606949807 kegg kegg NA NA no up no no no up Maturity onset diabetes of the young Taurine and hypotaurine metabolism 0.44 0 0.456885457 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Th1 and Th2 cell differentiation 0.428695652 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Type I diabetes mellitus 0 -0.511857708 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Type II diabetes mellitus 0 0 0.484169884 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Viral protein interaction with cytokine and cytokine receptor -0.473043478 0 0 kegg kegg NA NA no up no no no no Maturity onset diabetes of the young Wnt signaling pathway 0 0 0.463577864 kegg kegg NA NA no up no no no no MCP-1(MCAF) 16:0/16:1-PC+blood 0 0 0.535338346 yes serum_cytokines serum_phospholipids 0.0633 0.00283 dn no no up up no MCP-1(MCAF) 16:0/18:1-PC+blood 0 0 0.583458647 yes serum_cytokines serum_phospholipids 0.0633 6.15E-07 dn no no up up up MCP-1(MCAF) 16:0/18:2-PC+blood 0.696969697 0 0 yes serum_cytokines serum_phospholipids 0.0633 3.24E-06 dn no no no up up MCP-1(MCAF) 16:1/16:0-PC+blood 0.76969697 0 0 yes serum_cytokines serum_phospholipids 0.0633 0.0215 dn no no no up up MCP-1(MCAF) 18:0/16:0-PC+blood 0 0 0.648120301 yes serum_cytokines serum_phospholipids 0.0633 9.64E-07 dn no no up up up MCP-1(MCAF) 18:1/16:0-PC+blood 0.757575758 0 0 yes serum_cytokines serum_phospholipids 0.0633 2.43E-05 dn no no no up up MCP-1(MCAF) 20:3/16:0-PC+blood 0.648484848 0 0 yes serum_cytokines serum_phospholipids 0.0633 0.00405 dn no no no up up MCP-1(MCAF) 20:4-LPC+blood 0 0 -0.515789474 yes serum_cytokines serum_phospholipids 0.0633 0.949 dn no no no no no MCP-1(MCAF) 24:1+blood 0.806060606 0 0 yes serum_cytokines serum_fattyacid 0.0633 0.00582 dn no no no dn dn MCP-1(MCAF) "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0 0 -0.477192982 yes serum_cytokines urine_cometabolism 0.0633 0.0125 dn no no up up no MCP-1(MCAF) AA+blood 0 0 -0.566917293 yes serum_cytokines serum_ARA 0.0633 0.212 dn no no no no no MCP-1(MCAF) ACA+blood 0.833995557 0 0 yes serum_cytokines serum_bileacids 0.0633 0.338 dn no no no no no MCP-1(MCAF) Acetic acid+stool 0.83030303 0 0 yes yes serum_cytokines stool_scfa 0.0633 0.0656 dn no no dn no no MCP-1(MCAF) Adherens junction 0 0 -0.48877942 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) AMPK signaling pathway 0.791208791 0 0 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) Apoptosis 0 0 -0.462506842 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) Betaine+blood 0 0 -0.566917293 yes serum_cytokines serum_choline 0.0633 0.857 dn no no no no no MCP-1(MCAF) Butyric acid+stool 0.733333333 0 0 yes yes serum_cytokines stool_scfa 0.0633 0.102 dn no no dn no no MCP-1(MCAF) Butyricicoccus -0.628970902 0 0 yes butyrate-producing serum_cytokines Genus 0.0633 0.852 dn no no no no no MCP-1(MCAF) Clostridium -0.580119351 0 0 yes serum_cytokines Genus 0.0633 0.925 dn no no no no no MCP-1(MCAF) d18:0-16:0-SM+blood 0 0 -0.452631579 yes serum_cytokines serum_phospholipids 0.0633 0.202 dn no no no no no MCP-1(MCAF) d18:1-14:0-SM+blood -0.733333333 0 0 yes serum_cytokines serum_phospholipids 0.0633 0.94 dn no no no no no MCP-1(MCAF) d18:1-16:0-SM+blood 0 0 -0.487218045 yes serum_cytokines serum_phospholipids 0.0633 0.14 dn no no no no no MCP-1(MCAF) d18:1-16:1-SM+blood -0.709090909 0 0 yes serum_cytokines serum_phospholipids 0.0633 0.2 dn no no no no no MCP-1(MCAF) d18:1-20:0-SM+blood -0.721212121 0 0 yes serum_cytokines serum_phospholipids 0.0633 0.933 dn no no no no no MCP-1(MCAF) d18:1-22:0-SM+blood -0.878787879 0 0 yes serum_cytokines serum_phospholipids 0.0633 0.522 dn no no no no no MCP-1(MCAF) d18:1-22:1-SM+blood -0.684848485 0 0 yes serum_cytokines serum_phospholipids 0.0633 0.222 dn no no no no no MCP-1(MCAF) DCA+blood 0 0 0.460150376 yes serum_cytokines serum_bileacids 0.0633 0.122 dn no no no no no MCP-1(MCAF) DL-Indole-3-lactic acid+urine -0.733333333 0 0 yes serum_cytokines urine_cometabolism 0.0633 0.00552 dn no no up up no MCP-1(MCAF) Eotaxin 0 0.509090909 0 yes serum_cytokines serum_cytokines 0.0633 0.393 dn no no no no no MCP-1(MCAF) Ethanolamine+blood 0.660606061 0 0 yes serum_cytokines serum_aminoacids 0.0633 0.122 dn no no up no no MCP-1(MCAF) Fc epsilon RI signaling pathway 0 0 -0.53256705 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) Fluid shear stress and atherosclerosis 0 0 -0.559386973 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) GM-CSF 0 0 -0.515461624 yes yes serum_cytokines serum_cytokines 0.0633 0.0124 dn no no up no no MCP-1(MCAF) HDCA+stool 0.733333333 0 0 yes serum_cytokines stool_bileacids 0.0633 0.176 dn no no no no no MCP-1(MCAF) Hematopoietic cell lineage 0.565934066 0 0 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) Hepatocellular carcinoma 0 0 -0.401751505 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) IL-4 0 0.614285714 0 yes serum_cytokines serum_cytokines 0.0633 0.858 dn no no no no no MCP-1(MCAF) IL-9 -0.642857143 0 0 yes serum_cytokines serum_cytokines 0.0633 0.906 dn no no no no no MCP-1(MCAF) Inflammatory bowel disease 0.554945055 0 0 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) Influenza A 0 0 -0.428024083 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) L-Asparagine+blood 0.648484848 0 0 yes serum_cytokines serum_aminoacids 0.0633 0.784 dn no no no no no MCP-1(MCAF) L-Tryptophan+stool -0.648484848 0 0 yes serum_cytokines stool_cometabolism 0.0633 0.557 dn no no no no no MCP-1(MCAF) Leukocyte transendothelial migration 0 0 -0.445539135 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) Malaria 0.686813187 0 0 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) Measles -0.708791209 0 0 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) Mineral absorption 0.56043956 0 0 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) Necroptosis 0.576923077 0 0 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) NF-kappa B signaling pathway -0.571428571 0 0 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) Parabacteroides 0.637362637 0 0 yes serum_cytokines Genus 0.0633 4.19E-05 dn no no no up up MCP-1(MCAF) Pathogenic Escherichia coli infection 0 0 -0.448275862 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) Propionic acid+stool 0.890909091 0 0 yes yes serum_cytokines stool_scfa 0.0633 0.0436 dn no no dn no up MCP-1(MCAF) Protein processing in endoplasmic reticulum 0 0 0.54077723 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) Purine metabolism 0.730769231 0 0 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) Rap1 signaling pathway 0 0 -0.439518336 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) Slackia 0 0 0.402716029 yes serum_cytokines Genus 0.0633 0.94 dn no no no no no MCP-1(MCAF) T cell receptor signaling pathway -0.598901099 0 0 yes serum_cytokines kegg 0.0633 NA dn no no no no no MCP-1(MCAF) total_stool_scfa+stool 0.806060606 0 0 yes serum_cytokines stool_scfa 0.0633 0.0534 dn no no dn no up MCP-1(MCAF) Yersinia infection 0 0 -0.565955118 yes serum_cytokines kegg 0.0633 NA dn no no no no no Measles ABC transporters 0.424347826 0 0 kegg kegg NA NA no no no no up up Measles Alcoholism 0 -0.616600791 0 kegg kegg NA NA no no no no no no Measles AMPK signaling pathway -0.547826087 0 0 kegg kegg NA NA no no no no no no Measles Apelin signaling pathway 0 0 0.507850708 kegg kegg NA NA no no no no no no Measles Arachidonic acid metabolism -0.486086957 0 0 kegg kegg NA NA no no no no no no Measles Autophagy - animal 0.56 0 0 kegg kegg NA NA no no no no no no Measles Autophagy - other 0.596521739 0 0 kegg kegg NA NA no no no no no no Measles Bile secretion 0 -0.583992095 0 kegg kegg NA NA no no no no no no Measles C-type lectin receptor signaling pathway 0.551304348 0 0 kegg kegg NA NA no no no no no no Measles Carbohydrate digestion and absorption 0.417391304 0 0 kegg kegg NA NA no no no no no no Measles Cell adhesion molecules -0.426086957 0 0 kegg kegg NA NA no no no no no no Measles Chagas disease 0.406956522 0 0 kegg kegg NA NA no no no no no no Measles Cholinergic synapse 0.424347826 0 0 kegg kegg NA NA no no no no no no Measles Circadian entrainment 0 -0.57312253 0 kegg kegg NA NA no no no no up up Measles Cytosolic DNA-sensing pathway 0 0.424901186 0 kegg kegg NA NA no no no no no no Measles Dopaminergic synapse 0 -0.493083004 0 kegg kegg NA NA no no no no up no Measles EGFR tyrosine kinase inhibitor resistance 0 0 0.545431145 kegg kegg NA NA no no no no no no Measles Endocrine and other factor-regulated calcium reabsorption -0.488695652 0 0 kegg kegg NA NA no no no no no no Measles Endocrine resistance 0 -0.415019763 0 kegg kegg NA NA no no no no no no Measles Folate biosynthesis 0.507826087 0 0 kegg kegg NA NA no no no no no no Measles FoxO signaling pathway 0.406956522 0 0 kegg kegg NA NA no no no no no no Measles Gap junction -0.48173913 -0.454545455 0 kegg kegg NA NA no no no no no no Measles Gastric acid secretion -0.433043478 0 0 kegg kegg NA NA no no no no no no Measles Glutamatergic synapse -0.523478261 -0.438735178 0 kegg kegg NA NA no no no no up up Measles Glutathione metabolism -0.52 0 0 kegg kegg NA NA no no no no no no Measles "Glycine, serine and threonine metabolism" -0.413043478 0 0 kegg kegg NA NA no no no no up no Measles Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.413913043 0 0 kegg kegg NA NA no no no no no no Measles Glycosphingolipid biosynthesis - ganglio series -0.413043478 0 0 kegg kegg NA NA no no no no no no Measles Hematopoietic cell lineage -0.505217391 0 0 kegg kegg NA NA no no no no no no Measles Hepatitis B 0.717391304 0 0 kegg kegg NA NA no no no no no no Measles Hepatitis C 0.717391304 0.605731225 0 kegg kegg NA NA no no no no no no Measles HIF-1 signaling pathway 0 0 0.602831403 kegg kegg NA NA no no no no no no Measles Hippo signaling pathway -0.453043478 0 0 kegg kegg NA NA no no no no no no Measles Hippo signaling pathway - multiple species 0.405217391 0 0 kegg kegg NA NA no no no no no no Measles Insulin resistance 0.645217391 0 0 kegg kegg NA NA no no no no no no Measles Insulin signaling pathway 0 0 0.503732304 kegg kegg NA NA no no no no no no Measles Legionellosis 0 0.559288538 0.446846847 kegg kegg NA NA no no no no no no Measles Leishmaniasis 0 0.416007905 0 kegg kegg NA NA no no no no no no Measles Malaria -0.586956522 0 0 kegg kegg NA NA no no no no no no Measles MAPK signaling pathway 0.546086957 0 0 kegg kegg NA NA no no no no no no Measles Maturity onset diabetes of the young 0 -0.482213439 0 kegg kegg NA NA no no no no up no Measles Morphine addiction 0 -0.548418972 0 kegg kegg NA NA no no no no up up Measles mTOR signaling pathway 0 0 0.544144144 kegg kegg NA NA no no no no no no Measles Neurotrophin signaling pathway 0.440869565 0 0 kegg kegg NA NA no no no no no no Measles NF-kappa B signaling pathway 0.49826087 0 0 kegg kegg NA NA no no no no no no Measles Ovarian steroidogenesis 0 -0.434782609 0 kegg kegg NA NA no no no no up up Measles Phagosome -0.42 0 0 kegg kegg NA NA no no no no no no Measles PI3K-Akt signaling pathway 0.699130435 0.631422925 0.467696268 yes kegg kegg NA NA no no no no up up Measles Platelet activation -0.428695652 -0.514822134 0 kegg kegg NA NA no no no no no no Measles Prevotella 0 -0.413635022 0 acetate-producing kegg Genus NA 0.287 no no no no no no Measles Progesterone-mediated oocyte maturation 0.551304348 0 0 kegg kegg NA NA no no no no no no Measles Proteasome 0 0 0.416473616 kegg kegg NA NA no no no no no no Measles Purine metabolism -0.55826087 0 0 kegg kegg NA NA no no no no no no Measles Rap1 signaling pathway 0 -0.519762846 0 kegg kegg NA NA no no no no no no Measles Regulation of lipolysis in adipocytes 0 -0.519762846 0 kegg kegg NA NA no no no no no no Measles Ribosome 0 0 0.521750322 kegg kegg NA NA no no no no no no Measles RIG-I-like receptor signaling pathway 0.692173913 0 0 kegg kegg NA NA no no no no no no Measles RNA transport 0.408695652 0.428853755 0.404118404 kegg kegg NA NA no no no no no no Measles Roseburia -0.422608696 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no Measles Salivary secretion -0.597391304 -0.548418972 0 kegg kegg NA NA no no no no no no Measles Selenocompound metabolism 0.406086957 0 0 kegg kegg NA NA no no no no no no Measles Serotonergic synapse 0 -0.517786561 0 kegg kegg NA NA no no no no no no Measles SNARE interactions in vesicular transport 0.459130435 0 0 kegg kegg NA NA no no no no no no Measles Spinocerebellar ataxia 0.433913043 0 0 kegg kegg NA NA no no no no no no Measles Spliceosome 0.510434783 0 0 kegg kegg NA NA no no no no no no Measles Sulfur metabolism -0.467826087 0 0 kegg kegg NA NA no no no no no no Measles T cell receptor signaling pathway 0.847826087 0.645256917 0 kegg kegg NA NA no no no no no no Measles Taste transduction 0.413043478 0 0 kegg kegg NA NA no no no no no up Measles Th1 and Th2 cell differentiation 0 0.52173913 0 kegg kegg NA NA no no no no no no Measles Th17 cell differentiation 0 0.648221344 0 kegg kegg NA NA no no no no no no Measles Thiamine metabolism 0.568695652 0 0 kegg kegg NA NA no no no no no no Measles Thyroid hormone synthesis -0.493913043 0 0 kegg kegg NA NA no no no no no no Measles TNF signaling pathway 0.509565217 0 0 kegg kegg NA NA no no no no no no Measles Toxoplasmosis 0 0.468379447 0 kegg kegg NA NA no no no no no no Measles Type I diabetes mellitus -0.502608696 0 0 kegg kegg NA NA no no no no no no Measles Vibrio cholerae infection -0.406956522 -0.458498024 0 kegg kegg NA NA no no no no no no Melanogenesis ABC transporters -0.549565217 0 0 kegg kegg NA NA no no no no up up Melanogenesis Adherens junction 0 0.545454545 0 kegg kegg NA NA no no no no no no Melanogenesis Adrenergic signaling in cardiomyocytes 0.66 0.850790514 0.881853282 kegg kegg NA NA no no no no no up Melanogenesis "Alanine, aspartate and glutamate metabolism" -0.683478261 -0.791501976 -0.424195624 kegg kegg NA NA no no no no no no Melanogenesis alpha-Linolenic acid metabolism -0.51826087 -0.625494071 -0.621621622 kegg kegg NA NA no no no no no no Melanogenesis Amino sugar and nucleotide sugar metabolism 0 0 -0.519433719 kegg kegg NA NA no no no no no no Melanogenesis AMPK signaling pathway 0 0.440711462 0 kegg kegg NA NA no no no no no no Melanogenesis Antigen processing and presentation -0.406956522 0 0 kegg kegg NA NA no no no no no no Melanogenesis Apelin signaling pathway 0 0.656126482 0 kegg kegg NA NA no no no no no no Melanogenesis Apoptosis -0.433043478 -0.618577075 -0.441698842 kegg kegg NA NA no no no no no no Melanogenesis Arginine and proline metabolism -0.705217391 -0.786561265 -0.468211068 kegg kegg NA NA no no no no up no Melanogenesis Arginine biosynthesis -0.671304348 -0.738142292 -0.42007722 kegg kegg NA NA no no no no no no Melanogenesis Ascorbate and aldarate metabolism 0 0 -0.443500644 kegg kegg NA NA no no no no no no Melanogenesis Autophagy - animal -0.409565217 -0.683794466 -0.400772201 kegg kegg NA NA no no no no no no Melanogenesis B cell receptor signaling pathway -0.406086957 -0.660079051 0 kegg kegg NA NA no no no no no no Melanogenesis Biosynthesis of amino acids -0.50173913 -0.753952569 -0.576576577 kegg kegg NA NA no no no no no no Melanogenesis Biosynthesis of cofactors 0 0.454545455 0 kegg kegg NA NA no no no no no no Melanogenesis C-type lectin receptor signaling pathway 0 -0.669960474 0 kegg kegg NA NA no no no no no no Melanogenesis Calcium signaling pathway 0.645217391 0.766798419 0.786357786 kegg kegg NA NA no no no no up up Melanogenesis cAMP signaling pathway 0 0 0.534105534 yes kegg kegg NA NA no no no no up up Melanogenesis Carbon metabolism 0 0 -0.634234234 kegg kegg NA NA no no no no no no Melanogenesis Cardiac muscle contraction 0.543478261 0.837944664 0.408494208 kegg kegg NA NA no no no no no up Melanogenesis Cell adhesion molecules 0 -0.550395257 0 kegg kegg NA NA no no no no no no Melanogenesis Cell cycle 0 0.505928854 0.42007722 kegg kegg NA NA no no no no no no Melanogenesis Cellular senescence 0 -0.453557312 0 kegg kegg NA NA no no no no no no Melanogenesis cGMP-PKG signaling pathway 0 -0.703557312 0 kegg kegg NA NA no no no no no no Melanogenesis Chemokine signaling pathway 0 -0.52173913 0 kegg kegg NA NA no no no no no no Melanogenesis Circadian entrainment 0.725217391 0.705533597 0.737709138 kegg kegg NA NA no no no no up up Melanogenesis Circadian rhythm 0 0.421936759 0 kegg kegg NA NA no no no no no no Melanogenesis Complement and coagulation cascades -0.439130435 -0.707509881 0 kegg kegg NA NA no no no no no no Melanogenesis Coprococcus 0 0 -0.41559946 butyrate-producing kegg Genus NA 0.612 no no no no no no Melanogenesis Cysteine and methionine metabolism 0 0.420948617 0 kegg kegg NA NA no no no no no no Melanogenesis DNA replication 0 0.483201581 0 kegg kegg NA NA no no no no no no Melanogenesis Dopaminergic synapse 0.593043478 0.755928854 0.857142857 kegg kegg NA NA no no no no up no Melanogenesis Drug metabolism - cytochrome P450 0 0.4743083 0 kegg kegg NA NA no no no no no no Melanogenesis Drug metabolism - other enzymes 0 0.486166008 -0.619047619 kegg kegg NA NA no no no no no no Melanogenesis ECM-receptor interaction 0 0 0.475675676 kegg kegg NA NA no no no no up up Melanogenesis EGFR tyrosine kinase inhibitor resistance 0 0.578063241 0 kegg kegg NA NA no no no no no no Melanogenesis Endocrine resistance 0.707826087 0.476284585 0.724581725 kegg kegg NA NA no no no no no no Melanogenesis Endocytosis 0 -0.524703557 0 kegg kegg NA NA no no no no no no Melanogenesis Estrogen signaling pathway 0.411304348 0.515810277 0.572972973 kegg kegg NA NA no no no no no no Melanogenesis Ether lipid metabolism 0.437391304 0.509881423 0 kegg kegg NA NA no no no no no no Melanogenesis Fatty acid biosynthesis -0.653043478 -0.779644269 -0.44015444 kegg kegg NA NA no no no no no no Melanogenesis Fatty acid degradation -0.655652174 -0.750988142 -0.631917632 kegg kegg NA NA no no no no no no Melanogenesis Fatty acid metabolism -0.648695652 -0.740118577 -0.522779923 kegg kegg NA NA no no no no no no Melanogenesis Fc epsilon RI signaling pathway 0 -0.691699605 -0.470527671 kegg kegg NA NA no no no no no no Melanogenesis Fc gamma R-mediated phagocytosis -0.475652174 -0.708498024 -0.43011583 kegg kegg NA NA no no no no no no Melanogenesis Focal adhesion 0 0.435770751 0 kegg kegg NA NA no no no no up up Melanogenesis Folate biosynthesis 0 0.421936759 0 kegg kegg NA NA no no no no no no Melanogenesis FoxO signaling pathway 0 -0.531620553 0 kegg kegg NA NA no no no no no no Melanogenesis Fructose and mannose metabolism -0.505217391 -0.435770751 -0.73951094 kegg kegg NA NA no no no no no no Melanogenesis GABAergic synapse -0.534782609 -0.574110672 0 kegg kegg NA NA no no no no up up Melanogenesis Galactose metabolism -0.479130435 -0.648221344 -0.674388674 kegg kegg NA NA no no no no no no Melanogenesis Gap junction 0.725217391 0 0.526640927 kegg kegg NA NA no no no no no no Melanogenesis Glutamatergic synapse 0.506086957 0 0.448648649 kegg kegg NA NA no no no no up up Melanogenesis Glutathione metabolism 0 0.593873518 0 kegg kegg NA NA no no no no no no Melanogenesis Glycerolipid metabolism -0.444347826 -0.422924901 0 kegg kegg NA NA no no no no no up Melanogenesis "Glycine, serine and threonine metabolism" 0 0.443675889 0 kegg kegg NA NA no no no no up no Melanogenesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.52 -0.591897233 0 kegg kegg NA NA no no no no no no Melanogenesis Glycosaminoglycan biosynthesis - keratan sulfate 0.532173913 0 0 kegg kegg NA NA no no no no no no Melanogenesis Glycosaminoglycan degradation 0 -0.538537549 -0.555469755 kegg kegg NA NA no no no no no up Melanogenesis Glyoxylate and dicarboxylate metabolism -0.763478261 -0.764822134 -0.517889318 kegg kegg NA NA no no no no no no Melanogenesis GnRH signaling pathway 0.727826087 0.704545455 0.884427284 kegg kegg NA NA no no no no no no Melanogenesis Hedgehog signaling pathway 0.42173913 0 0 kegg kegg NA NA no no no no no no Melanogenesis HIF-1 signaling pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Melanogenesis Hippo signaling pathway 0.514782609 0.605731225 0 kegg kegg NA NA no no no no no no Melanogenesis Hippo signaling pathway - multiple species -0.466956522 -0.652173913 -0.473359073 kegg kegg NA NA no no no no no no Melanogenesis Histidine metabolism 0 0 -0.596138996 kegg kegg NA NA no no no no no no Melanogenesis IL-17 signaling pathway -0.524347826 -0.657114625 -0.516087516 kegg kegg NA NA no no no no no no Melanogenesis Inflammatory mediator regulation of TRP channels 0.805217391 0.949604743 0.93951094 kegg kegg NA NA no no no no no no Melanogenesis Insulin secretion 0.75826087 0.721343874 0.811840412 yes kegg kegg NA NA no no no no up up Melanogenesis Insulin signaling pathway 0 0.591897233 0 kegg kegg NA NA no no no no no no Melanogenesis JAK-STAT signaling pathway 0 -0.585968379 0 kegg kegg NA NA no no no no no no Melanogenesis Long-term depression 0.764347826 0.423913043 0.718146718 kegg kegg NA NA no no no no no no Melanogenesis Lysosome 0 -0.544466403 -0.677477477 kegg kegg NA NA no no no no no no Melanogenesis MAPK signaling pathway 0 -0.543478261 0 kegg kegg NA NA no no no no no no Melanogenesis Metabolism of xenobiotics by cytochrome P450 0 0.427865613 0 kegg kegg NA NA no no no no no no Melanogenesis Mitophagy - animal 0.508695652 0.690711462 0 kegg kegg NA NA no no no no no no Melanogenesis mRNA surveillance pathway 0 0.690711462 0.441184041 kegg kegg NA NA no no no no no no Melanogenesis mTOR signaling pathway 0 0.549407115 0 kegg kegg NA NA no no no no no no Melanogenesis N-Glycan biosynthesis 0 0.624505929 0 kegg kegg NA NA no no no no no no Melanogenesis Natural killer cell mediated cytotoxicity 0 -0.460474308 0 kegg kegg NA NA no no no no no no Melanogenesis Necroptosis 0.447826087 0 0 kegg kegg NA NA no no no no no no Melanogenesis Neuroactive ligand-receptor interaction 0 -0.625494071 -0.516859717 kegg kegg NA NA no no no up up up Melanogenesis Neurotrophin signaling pathway 0 -0.485177866 0 kegg kegg NA NA no no no no no no Melanogenesis Neutrophil extracellular trap formation -0.446086957 -0.598814229 -0.428314028 kegg kegg NA NA no no no no no no Melanogenesis NF-kappa B signaling pathway -0.662608696 -0.684782609 0 kegg kegg NA NA no no no no no no Melanogenesis Nicotinate and nicotinamide metabolism -0.686956522 -0.714426877 -0.580694981 kegg kegg NA NA no no no no no no Melanogenesis Nitrogen metabolism -0.566956522 -0.643280632 0 kegg kegg NA NA no no no no no no Melanogenesis NOD-like receptor signaling pathway -0.734782609 -0.766798419 0 kegg kegg NA NA no no no no no no Melanogenesis Nucleotide excision repair 0 0.416007905 0 kegg kegg NA NA no no no no no no Melanogenesis Olfactory transduction 0 -0.605731225 -0.588159588 kegg kegg NA NA no no no no no no Melanogenesis One carbon pool by folate 0 0.467391304 0 kegg kegg NA NA no no no no no no Melanogenesis Oocyte meiosis 0 0 0.472329472 kegg kegg NA NA no no no no no no Melanogenesis Oscillospira 0 -0.502964427 0 LPS-producing kegg Genus NA 0.62 no no no no no no Melanogenesis Osteoclast differentiation -0.664347826 -0.77173913 -0.467696268 kegg kegg NA NA no no no no no no Melanogenesis Other glycan degradation -0.671304348 0 0 kegg kegg NA NA no no no no no no Melanogenesis Ovarian steroidogenesis 0.812173913 0.584980237 0.634749035 kegg kegg NA NA no no no no up up Melanogenesis Oxidative phosphorylation 0.52 0.833003953 0 kegg kegg NA NA no no no no no no Melanogenesis Pantothenate and CoA biosynthesis -0.509565217 -0.747035573 -0.667953668 kegg kegg NA NA no no no no no dn Melanogenesis Pentose and glucuronate interconversions 0 0.513833992 0 kegg kegg NA NA no no no no no no Melanogenesis Pentose phosphate pathway -0.42173913 -0.672924901 -0.644272844 kegg kegg NA NA no no no no no no Melanogenesis Peroxisome -0.69826087 -0.800395257 -0.411583012 kegg kegg NA NA no no no no no no Melanogenesis Phagosome 0 -0.542490119 0 kegg kegg NA NA no no no no no no Melanogenesis Phosphatidylinositol signaling system 0.411304348 0 0 kegg kegg NA NA no no no no no no Melanogenesis Phototransduction 0.525217391 0 0 kegg kegg NA NA no no no no no no Melanogenesis Platelet activation 0.469565217 0.492094862 0 kegg kegg NA NA no no no no no no Melanogenesis PPAR signaling pathway -0.610434783 -0.802371542 0 kegg kegg NA NA no no no no no no Melanogenesis Prevotella 0 0 0.503406166 acetate-producing kegg Genus NA 0.287 no no no no no no Melanogenesis Proteasome 0 0 -0.471042471 kegg kegg NA NA no no no no no no Melanogenesis Protein export 0 0.634387352 0 kegg kegg NA NA no no no no no no Melanogenesis Protein processing in endoplasmic reticulum 0.416521739 0.610671937 0 kegg kegg NA NA no no no no no no Melanogenesis Purine metabolism 0 0.466403162 0 kegg kegg NA NA no no no no no no Melanogenesis Pyrimidine metabolism -0.417391304 0.448616601 -0.401029601 kegg kegg NA NA no no no no no no Melanogenesis Pyruvate metabolism 0 0.501976285 0 kegg kegg NA NA no no no no no no Melanogenesis Ras signaling pathway 0 0.581027668 0 yes kegg kegg NA NA no no no no up up Melanogenesis Renin-angiotensin system 0 -0.625494071 -0.499099099 kegg kegg NA NA no no no no no no Melanogenesis Retrograde endocannabinoid signaling 0 0.761857708 0 kegg kegg NA NA no no no no no up Melanogenesis Ribosome 0.435652174 0.730237154 0 kegg kegg NA NA no no no no no no Melanogenesis Ribosome biogenesis in eukaryotes 0 0.451581028 0 kegg kegg NA NA no no no no no no Melanogenesis RIG-I-like receptor signaling pathway -0.599130435 -0.707509881 0 kegg kegg NA NA no no no no no no Melanogenesis RNA degradation 0 0.719367589 0 kegg kegg NA NA no no no no no no Melanogenesis RNA polymerase 0 0.631422925 0 kegg kegg NA NA no no no no no no Melanogenesis RNA transport 0 0.419960474 0 kegg kegg NA NA no no no no no no Melanogenesis Serotonergic synapse 0.414782609 0 0 kegg kegg NA NA no no no no no no Melanogenesis SNARE interactions in vesicular transport -0.539130435 -0.593873518 0 kegg kegg NA NA no no no no no no Melanogenesis Sphingolipid metabolism 0 0 -0.576833977 kegg kegg NA NA no no no no no no Melanogenesis Sphingolipid signaling pathway 0 -0.441699605 0 kegg kegg NA NA no no no no no no Melanogenesis Starch and sucrose metabolism -0.602608696 -0.749011858 -0.804633205 kegg kegg NA NA no no no no no no Melanogenesis Steroid biosynthesis 0.479130435 0 0 kegg kegg NA NA no no no no no no Melanogenesis Synaptic vesicle cycle 0 -0.660079051 -0.714543115 kegg kegg NA NA no no no no up up Melanogenesis T cell receptor signaling pathway 0 -0.542490119 0 kegg kegg NA NA no no no no no no Melanogenesis Taste transduction 0 0.43972332 0 kegg kegg NA NA no no no no no up Melanogenesis TGF-beta signaling pathway 0.499130435 0.640316206 0 kegg kegg NA NA no no no no no no Melanogenesis Th1 and Th2 cell differentiation 0 -0.450592885 0 kegg kegg NA NA no no no no no no Melanogenesis Th17 cell differentiation 0 -0.483201581 0 kegg kegg NA NA no no no no no no Melanogenesis Thermogenesis 0.625217391 0.852766798 0.422651223 kegg kegg NA NA no no no no no no Melanogenesis TNF signaling pathway 0 -0.558300395 0 kegg kegg NA NA no no no no no no Melanogenesis Toll-like receptor signaling pathway -0.439130435 -0.711462451 0 yes kegg kegg NA NA no no no no no no Melanogenesis Ubiquitin mediated proteolysis 0.579130435 0.743083004 0 kegg kegg NA NA no no no no no no Melanogenesis Vascular smooth muscle contraction 0.717391304 0.837944664 0.679279279 kegg kegg NA NA no no no no no no Melanogenesis VEGF signaling pathway 0 -0.414031621 0 kegg kegg NA NA no no no no no no Melanogenesis Wnt signaling pathway 0.597391304 0.717391304 0 kegg kegg NA NA no no no no no no Melanoma 2-Oxocarboxylic acid metabolism -0.69826087 -0.663043478 0 kegg kegg NA NA no no no no no no Melanoma Adherens junction -0.472173913 -0.627470356 0 kegg kegg NA NA no no no no no no Melanoma Adipocytokine signaling pathway 0 0.651185771 0 kegg kegg NA NA no no no no no no Melanoma African trypanosomiasis 0.47826087 0.431818182 0 kegg kegg NA NA no no no no no no Melanoma AGE-RAGE signaling pathway in diabetic complications 0.449565217 0.740118577 0.664607465 kegg kegg NA NA no no no no no no Melanoma "Alanine, aspartate and glutamate metabolism" 0 0.641304348 0 kegg kegg NA NA no no no no no no Melanoma Aldosterone-regulated sodium reabsorption 0.857391304 0.757905138 0.753153153 kegg kegg NA NA no no no no no no Melanoma Alzheimer disease 0 -0.468379447 0 kegg kegg NA NA no no no no no no Melanoma Amino sugar and nucleotide sugar metabolism -0.523478261 0 0 kegg kegg NA NA no no no no no no Melanoma Aminoacyl-tRNA biosynthesis -0.488695652 -0.58201581 0 kegg kegg NA NA no no no no no no Melanoma Amoebiasis 0 0.67687747 0 kegg kegg NA NA no no no no no no Melanoma Amphetamine addiction 0 -0.497035573 0 kegg kegg NA NA no no no no no no Melanoma Amyotrophic lateral sclerosis 0 -0.526679842 0 kegg kegg NA NA no no no no no no Melanoma Antifolate resistance -0.468695652 0 0 kegg kegg NA NA no no no no no no Melanoma Apelin signaling pathway 0 -0.574110672 0 kegg kegg NA NA no no no no no no Melanoma Apoptosis 0 0.633399209 0 kegg kegg NA NA no no no no no no Melanoma Arachidonic acid metabolism -0.593043478 0 -0.547232947 kegg kegg NA NA no no no no no no Melanoma Arginine and proline metabolism 0 0.645256917 0 kegg kegg NA NA no no no no up no Melanoma Arginine biosynthesis 0 0.618577075 0 kegg kegg NA NA no no no no no no Melanoma Ascorbate and aldarate metabolism -0.486956522 -0.600790514 0 kegg kegg NA NA no no no no no no Melanoma Autophagy - animal 0.84 0.876482213 0.806177606 kegg kegg NA NA no no no no no no Melanoma Autophagy - other 0.624347826 0.505928854 0.651994852 kegg kegg NA NA no no no no no no Melanoma Axon guidance 0.547826087 0 0.548262548 kegg kegg NA NA no no no no up up Melanoma B cell receptor signaling pathway 0.449565217 0.736166008 0 kegg kegg NA NA no no no no no no Melanoma Bacterial invasion of epithelial cells -0.522608696 -0.585968379 0 kegg kegg NA NA no no no no no no Melanoma Basal cell carcinoma 0 0 0.475675676 kegg kegg NA NA no no no no no no Melanoma beta-Alanine metabolism -0.706086957 -0.71541502 0 kegg kegg NA NA no no no no no no Melanoma Biosynthesis of cofactors -0.720869565 -0.456521739 0 kegg kegg NA NA no no no no no no Melanoma Biosynthesis of unsaturated fatty acids -0.606086957 -0.595849802 0 kegg kegg NA NA no no no no no no Melanoma Butanoate metabolism -0.736521739 -0.843873518 0 kegg kegg NA NA no no no no no no Melanoma C-type lectin receptor signaling pathway 0.859130435 0.786561265 0.639124839 kegg kegg NA NA no no no no no no Melanoma cAMP signaling pathway 0.662608696 0.618577075 0 yes kegg kegg NA NA no no no no up up Melanoma Carbohydrate digestion and absorption 0.843478261 0.788537549 0.701158301 kegg kegg NA NA no no no no no no Melanoma Carbon metabolism -0.596521739 0 0 kegg kegg NA NA no no no no no no Melanoma Cardiac muscle contraction 0 -0.43972332 0 kegg kegg NA NA no no no no no up Melanoma Cell cycle 0 -0.414031621 0 kegg kegg NA NA no no no no no no Melanoma Cellular senescence 0 0.470355731 0 kegg kegg NA NA no no no no no no Melanoma cGMP-PKG signaling pathway 0.683478261 0.472332016 0.466924067 kegg kegg NA NA no no no no no no Melanoma Chagas disease 0.640869565 0.82312253 0 kegg kegg NA NA no no no no no no Melanoma Chemokine signaling pathway 0 0.564229249 0 kegg kegg NA NA no no no no no no Melanoma Cholinergic synapse 0.770434783 0 0.635778636 kegg kegg NA NA no no no no no no Melanoma Circadian entrainment 0 -0.58201581 -0.507593308 kegg kegg NA NA no no no no up up Melanoma Circadian rhythm 0.629565217 0 0.483655084 kegg kegg NA NA no no no no no no Melanoma Citrate cycle (TCA cycle) -0.643478261 -0.864624506 0 kegg kegg NA NA no no no no no no Melanoma Colorectal cancer 0.613913043 0 0.710939511 kegg kegg NA NA no no no no no no Melanoma Coronavirus disease - COVID-19 0 -0.47826087 -0.465379665 kegg kegg NA NA no no no no no no Melanoma Cysteine and methionine metabolism 0 -0.76284585 0 kegg kegg NA NA no no no no no no Melanoma Cytokine-cytokine receptor interaction 0 0 -0.47979408 kegg kegg NA NA no no no no no no Melanoma Cytosolic DNA-sensing pathway 0 0.574110672 0 kegg kegg NA NA no no no no no no Melanoma DNA replication 0 -0.732213439 0 kegg kegg NA NA no no no no no no Melanoma Drug metabolism - cytochrome P450 -0.409565217 -0.878458498 -0.47027027 kegg kegg NA NA no no no no no no Melanoma Drug metabolism - other enzymes -0.606956522 -0.849802372 0 kegg kegg NA NA no no no no no no Melanoma ECM-receptor interaction -0.424347826 0 0 kegg kegg NA NA no no no no up up Melanoma Endometrial cancer 0.828695652 0.935770751 0.848906049 kegg kegg NA NA no no no no no no Melanoma Epithelial cell signaling in Helicobacter pylori infection 0 0.631422925 0 kegg kegg NA NA no no no no no no Melanoma ErbB signaling pathway 0.750434783 0.791501976 0.813642214 kegg kegg NA NA no no no no no no Melanoma Estrogen signaling pathway 0 -0.734189723 0 kegg kegg NA NA no no no no no no Melanoma Fatty acid biosynthesis 0 0.617588933 0 kegg kegg NA NA no no no no no no Melanoma Fatty acid elongation -0.680869565 -0.630434783 0 kegg kegg NA NA no no no no no no Melanoma Fc epsilon RI signaling pathway 0.626956522 0.779644269 0.517374517 kegg kegg NA NA no no no no no no Melanoma Ferroptosis 0 0 -0.411325611 kegg kegg NA NA no no no no no no Melanoma Focal adhesion -0.468695652 -0.723320158 0 kegg kegg NA NA no no no no up up Melanoma FoxO signaling pathway 0.523478261 0.572134387 0 kegg kegg NA NA no no no no no no Melanoma Fructose and mannose metabolism -0.497391304 0 0 kegg kegg NA NA no no no no no no Melanoma GABAergic synapse 0.427826087 0.566205534 0 kegg kegg NA NA no no no no up up Melanoma Galactose metabolism -0.48173913 0 0 kegg kegg NA NA no no no no no no Melanoma Gastric acid secretion -0.488695652 -0.692687747 -0.483912484 kegg kegg NA NA no no no no no no Melanoma Glioma 0.717391304 0.601778656 0.654311454 kegg kegg NA NA no no no no no no Melanoma Glucagon signaling pathway 0 -0.485177866 0 kegg kegg NA NA no no no no no no Melanoma Glutamatergic synapse 0 0.480237154 0 kegg kegg NA NA no no no no up up Melanoma Glutathione metabolism -0.489565217 -0.481225296 -0.640669241 kegg kegg NA NA no no no no no no Melanoma "Glycine, serine and threonine metabolism" -0.594782609 0 0 kegg kegg NA NA no no no no up no Melanoma Glycolysis / Gluconeogenesis -0.650434783 -0.752964427 0 kegg kegg NA NA no no no no no no Melanoma Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.45826087 0.807312253 0.434749035 kegg kegg NA NA no no no no no no Melanoma Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.547826087 0 0 kegg kegg NA NA no no no no no no Melanoma Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.427027027 kegg kegg NA NA no no no no no no Melanoma Glycosphingolipid biosynthesis - ganglio series 0 -0.497035573 0 kegg kegg NA NA no no no no no no Melanoma Glycosphingolipid biosynthesis - lacto and neolacto series 0.414782609 0 0.442728443 kegg kegg NA NA no no no no no no Melanoma Glyoxylate and dicarboxylate metabolism 0 0.624505929 0 kegg kegg NA NA no no no no no no Melanoma GnRH secretion 0.793913043 0.809288538 0.761904762 kegg kegg NA NA no no no no up up Melanoma "Growth hormone synthesis, secretion and action" 0.591304348 0.600790514 0 kegg kegg NA NA no no no no no no Melanoma Hedgehog signaling pathway 0 0 0.524066924 kegg kegg NA NA no no no no no no Melanoma Hematopoietic cell lineage 0 -0.60770751 0 kegg kegg NA NA no no no no no no Melanoma Hepatitis B 0.771304348 0.815217391 0.762934363 kegg kegg NA NA no no no no no no Melanoma Hepatitis C 0.66173913 0.625494071 0.61029601 kegg kegg NA NA no no no no no no Melanoma HIF-1 signaling pathway 0 -0.475296443 0 kegg kegg NA NA no no no no no no Melanoma Hippo signaling pathway -0.546086957 -0.666007905 0 kegg kegg NA NA no no no no no no Melanoma Hippo signaling pathway - multiple species 0 0.483201581 0.444530245 kegg kegg NA NA no no no no no no Melanoma Histidine metabolism -0.426956522 0 0 kegg kegg NA NA no no no no no no Melanoma Human papillomavirus infection 0 0.493083004 0 kegg kegg NA NA no no no no no no Melanoma Huntington disease 0 -0.483201581 0 kegg kegg NA NA no no no no no no Melanoma IL-17 signaling pathway 0.470434783 0.448616601 0 kegg kegg NA NA no no no no no no Melanoma Inflammatory mediator regulation of TRP channels 0 -0.47826087 0 kegg kegg NA NA no no no no no no Melanoma Insulin resistance 0.7 0.842885375 0.62960103 kegg kegg NA NA no no no no no no Melanoma Insulin signaling pathway 0 -0.508893281 0 kegg kegg NA NA no no no no no no Melanoma JAK-STAT signaling pathway 0 0.68972332 0 kegg kegg NA NA no no no no no no Melanoma Linoleic acid metabolism -0.427826087 0 0 kegg kegg NA NA no no no no no no Melanoma Long-term potentiation 0.469565217 -0.497035573 0.453281853 kegg kegg NA NA no no no no no up Melanoma Longevity regulating pathway 0.42 0 0 kegg kegg NA NA no no no no no no Melanoma Lysine degradation 0 0 0.404118404 kegg kegg NA NA no no no no no no Melanoma Malaria 0 0.441699605 0 kegg kegg NA NA no no no no no no Melanoma MAPK signaling pathway 0 0 0.709395109 kegg kegg NA NA no no no no no no Melanoma Melanogenesis 0 -0.471343874 0 kegg kegg NA NA no no no no no no Melanoma Metabolism of xenobiotics by cytochrome P450 -0.464347826 -0.904150198 -0.507850708 kegg kegg NA NA no no no no no no Melanoma MicroRNAs in cancer 0.489565217 0.897233202 0.853796654 kegg kegg NA NA no no no no no no Melanoma Mineral absorption 0 0 -0.476705277 kegg kegg NA NA no no no no no no Melanoma Mismatch repair -0.526086957 -0.688735178 0 kegg kegg NA NA no no no no no no Melanoma mRNA surveillance pathway 0.430434783 0 0 kegg kegg NA NA no no no no no no Melanoma N-Glycan biosynthesis 0 -0.619565217 0 kegg kegg NA NA no no no no no no Melanoma Necroptosis 0 0 -0.402316602 kegg kegg NA NA no no no no no no Melanoma Neurotrophin signaling pathway 0.745217391 0.781620553 0.592277992 kegg kegg NA NA no no no no no no Melanoma NF-kappa B signaling pathway 0.405217391 0.821146245 0.556499356 kegg kegg NA NA no no no no no no Melanoma Nicotinate and nicotinamide metabolism 0 0.68083004 0 kegg kegg NA NA no no no no no no Melanoma Nitrogen metabolism 0 0.652173913 0 kegg kegg NA NA no no no no no no Melanoma NOD-like receptor signaling pathway 0 0.68972332 0 kegg kegg NA NA no no no no no no Melanoma Non-homologous end-joining -0.674782609 -0.683794466 0 kegg kegg NA NA no no no no no no Melanoma Notch signaling pathway 0.56173913 0.568181818 0.487516088 kegg kegg NA NA no no no no no no Melanoma Nucleotide excision repair 0 -0.662055336 0 kegg kegg NA NA no no no no no no Melanoma One carbon pool by folate 0 -0.651185771 0 kegg kegg NA NA no no no no no no Melanoma Oocyte meiosis 0 -0.644268775 0 kegg kegg NA NA no no no no no no Melanoma Osteoclast differentiation 0 0.636363636 0 kegg kegg NA NA no no no no no no Melanoma Other types of O-glycan biosynthesis 0 0 0.416473616 kegg kegg NA NA no no no no no no Melanoma Oxidative phosphorylation 0 -0.462450593 0 kegg kegg NA NA no no no no no no Melanoma Oxytocin signaling pathway -0.413913043 -0.424901186 -0.509137709 kegg kegg NA NA no no no no no no Melanoma p53 signaling pathway 0.444347826 0 0 kegg kegg NA NA no no no no no no Melanoma Pancreatic cancer 0.624347826 0 0.493951094 kegg kegg NA NA no no no no no no Melanoma Pantothenate and CoA biosynthesis 0 0.447628458 0 kegg kegg NA NA no no no no no dn Melanoma Parkinson disease 0 0 -0.543371943 kegg kegg NA NA no no no no no no Melanoma Pathways in cancer 0.633913043 0.7243083 0.451737452 kegg kegg NA NA no no no no no no Melanoma Pathways of neurodegeneration - multiple diseases 0 0 -0.538223938 kegg kegg NA NA no no no no no no Melanoma Pentose and glucuronate interconversions -0.7 -0.793478261 0 kegg kegg NA NA no no no no no no Melanoma Phenylalanine metabolism -0.783478261 -0.842885375 0 kegg kegg NA NA no no no no no no Melanoma Phosphatidylinositol signaling system 0.477391304 0 0.489060489 kegg kegg NA NA no no no no no no Melanoma Phospholipase D signaling pathway 0 0.755928854 0 kegg kegg NA NA no no no no up up Melanoma Phototransduction 0 -0.717391304 0 kegg kegg NA NA no no no no no no Melanoma Platelet activation -0.487826087 -0.575098814 0 kegg kegg NA NA no no no no no no Melanoma Porphyrin and chlorophyll metabolism -0.535652174 0 0 kegg kegg NA NA no no no no no no Melanoma PPAR signaling pathway 0 0.650197628 0 kegg kegg NA NA no no no no no no Melanoma Primary bile acid biosynthesis -0.60173913 -0.696640316 0 kegg kegg NA NA no no no no no no Melanoma Prion disease 0 -0.533596838 0 kegg kegg NA NA no no no no no no Melanoma Progesterone-mediated oocyte maturation 0.549565217 0 0.577863578 kegg kegg NA NA no no no no no no Melanoma Prolactin signaling pathway 0.806956522 0.704545455 0.641184041 kegg kegg NA NA no no no no no no Melanoma Propanoate metabolism 0 -0.740118577 0 kegg kegg NA NA no no no no no no Melanoma Prostate cancer 0.796521739 0.827075099 0.588159588 kegg kegg NA NA no no no no no no Melanoma Proteasome 0 -0.743083004 0 kegg kegg NA NA no no no no no no Melanoma Protein digestion and absorption 0 0 0.505019305 yes kegg kegg NA NA no no no no up up Melanoma Protein export 0 -0.593873518 0 kegg kegg NA NA no no no no no no Melanoma Protein processing in endoplasmic reticulum 0 -0.590909091 0 kegg kegg NA NA no no no no no no Melanoma Proteoglycans in cancer 0 -0.459486166 0 kegg kegg NA NA no no no no no no Melanoma Proximal tubule bicarbonate reclamation 0 -0.700592885 0 kegg kegg NA NA no no no no no no Melanoma Pyrimidine metabolism -0.474782609 -0.64229249 0 kegg kegg NA NA no no no no no no Melanoma Pyruvate metabolism -0.475652174 -0.777667984 -0.454568855 kegg kegg NA NA no no no no no no Melanoma Ras signaling pathway 0 -0.493083004 0 yes kegg kegg NA NA no no no no up up Melanoma Regulation of actin cytoskeleton -0.487826087 -0.645256917 -0.482882883 kegg kegg NA NA no no no no no no Melanoma Relaxin signaling pathway 0.566086957 0.658102767 0 kegg kegg NA NA no no no no no no Melanoma Renal cell carcinoma 0.606086957 0 0 kegg kegg NA NA no no no no no no Melanoma Renin secretion 0 -0.617588933 -0.444787645 kegg kegg NA NA no no no no no no Melanoma Retinol metabolism -0.46 -0.673913043 0 kegg kegg NA NA no no no no no no Melanoma Retrograde endocannabinoid signaling 0 -0.527667984 0 kegg kegg NA NA no no no no no up Melanoma Ribosome 0 -0.485177866 -0.466924067 kegg kegg NA NA no no no no no no Melanoma Ribosome biogenesis in eukaryotes 0 -0.448616601 0 kegg kegg NA NA no no no no no no Melanoma RIG-I-like receptor signaling pathway 0.676521739 0.841897233 0.483912484 kegg kegg NA NA no no no no no no Melanoma RNA degradation 0 -0.495059289 0 kegg kegg NA NA no no no no no no Melanoma RNA polymerase 0 -0.532608696 0 kegg kegg NA NA no no no no no no Melanoma Shigellosis 0 0 -0.512741313 kegg kegg NA NA no no no no no no Melanoma Signaling pathways regulating pluripotency of stem cells 0.717391304 0.502964427 0.711711712 kegg kegg NA NA no no no no no no Melanoma SNARE interactions in vesicular transport 0 0.470355731 0 kegg kegg NA NA no no no no no no Melanoma Sphingolipid signaling pathway 0.846086957 0.631422925 0.587129987 kegg kegg NA NA no no no no no no Melanoma Spinocerebellar ataxia 0.66 0 0 kegg kegg NA NA no no no no no no Melanoma Starch and sucrose metabolism 0 0.45256917 0 kegg kegg NA NA no no no no no no Melanoma Steroid biosynthesis 0 -0.7243083 0 kegg kegg NA NA no no no no no no Melanoma Steroid hormone biosynthesis -0.59826087 -0.722332016 0 kegg kegg NA NA no no no no no no Melanoma Sulfur metabolism -0.564347826 0 0 kegg kegg NA NA no no no no no no Melanoma Synthesis and degradation of ketone bodies -0.462608696 -0.621541502 0 kegg kegg NA NA no no no no no no Melanoma T cell receptor signaling pathway 0.442608696 0.532608696 0.537966538 kegg kegg NA NA no no no no no no Melanoma Taste transduction 0 -0.595849802 0 kegg kegg NA NA no no no no no up Melanoma Taurine and hypotaurine metabolism 0 0.568181818 0 kegg kegg NA NA no no no no no no Melanoma TGF-beta signaling pathway 0 -0.550395257 0 kegg kegg NA NA no no no no no no Melanoma Thermogenesis 0 -0.517786561 -0.442213642 kegg kegg NA NA no no no no no no Melanoma Thiamine metabolism 0 -0.57312253 0 kegg kegg NA NA no no no no no no Melanoma Thyroid hormone signaling pathway 0 -0.481225296 0 kegg kegg NA NA no no no no no no Melanoma Thyroid hormone synthesis 0 0 -0.462805663 kegg kegg NA NA no no no no no no Melanoma Tight junction -0.582608696 -0.622529644 -0.594851995 kegg kegg NA NA no no no no no no Melanoma TNF signaling pathway 0.757391304 0.836956522 0.515315315 kegg kegg NA NA no no no no no no Melanoma Toll-like receptor signaling pathway 0.731304348 0.772727273 0 yes kegg kegg NA NA no no no no no no Melanoma Transcriptional misregulation in cancer 0.653913043 0.82312253 0.645559846 kegg kegg NA NA no no no no no no Melanoma Tryptophan metabolism -0.684347826 -0.777667984 0 kegg kegg NA NA no no no no up no Melanoma Type II diabetes mellitus 0.923478261 0.854743083 0.707078507 kegg kegg NA NA no no no no no no Melanoma Tyrosine metabolism -0.711304348 -0.822134387 -0.499356499 kegg kegg NA NA no no no no no no Melanoma Ubiquinone and other terpenoid-quinone biosynthesis -0.63826087 -0.731225296 0 kegg kegg NA NA no no no no no no Melanoma Ubiquitin mediated proteolysis 0 0 -0.423166023 kegg kegg NA NA no no no no no no Melanoma "Valine, leucine and isoleucine degradation" -0.642608696 -0.833003953 0 kegg kegg NA NA no no no no no no Melanoma Various types of N-glycan biosynthesis 0 -0.473320158 0 kegg kegg NA NA no no no no no no Melanoma Vascular smooth muscle contraction 0 -0.52173913 0 kegg kegg NA NA no no no no no no Melanoma Vasopressin-regulated water reabsorption 0 -0.424901186 -0.462548263 kegg kegg NA NA no no no no no no Melanoma VEGF signaling pathway 0.810434783 0.791501976 0.77014157 kegg kegg NA NA no no no no no no Melanoma Vibrio cholerae infection -0.455652174 -0.619565217 -0.518404118 kegg kegg NA NA no no no no no no Melanoma Viral carcinogenesis 0 0.519762846 0 kegg kegg NA NA no no no no no no Melanoma Viral protein interaction with cytokine and cytokine receptor 0 0 -0.534362934 kegg kegg NA NA no no no no no no Melanoma Vitamin digestion and absorption 0.413913043 0 0 kegg kegg NA NA no no no no no no Melanoma Wnt signaling pathway 0 -0.477272727 0.404375804 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 "Alanine, aspartate and glutamate metabolism" 0 -0.706521739 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 alpha-Linolenic acid metabolism 0.526956522 0 0.524581725 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Amino sugar and nucleotide sugar metabolism 0.543478261 0 0.431402831 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Aminoacyl-tRNA biosynthesis 0.413913043 0.612648221 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Arachidonic acid metabolism 0.54 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Arginine and proline metabolism 0 -0.651185771 0 kegg kegg NA NA no no no no up no Metabolism of xenobiotics by cytochrome P450 Arginine biosynthesis 0 -0.723320158 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Ascorbate and aldarate metabolism 0 0.68972332 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 beta-Alanine metabolism 0.499130435 0.751976285 0.577606178 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Butanoate metabolism 0.406086957 0.877470356 0.485199485 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Citrate cycle (TCA cycle) 0.555652174 0.925889328 0.402574003 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Cysteine and methionine metabolism 0.55826087 0.792490119 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Fatty acid biosynthesis 0 -0.683794466 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Fatty acid elongation 0.493043478 0.675889328 0.605148005 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Folate biosynthesis 0 0.477272727 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Glutathione metabolism 0.495652174 0.454545455 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Glycerophospholipid metabolism -0.436521739 0 0 kegg kegg NA NA no no no no no up Metabolism of xenobiotics by cytochrome P450 Glycolysis / Gluconeogenesis 0.653043478 0.769762846 0.533333333 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.791501976 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.528656126 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Glycosaminoglycan biosynthesis - keratan sulfate -0.610434783 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Glycosphingolipid biosynthesis - ganglio series 0 0.556324111 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Glycosphingolipid biosynthesis - globo and isoglobo series 0.496521739 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Glycosphingolipid biosynthesis - lacto and neolacto series -0.683478261 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Glyoxylate and dicarboxylate metabolism 0 -0.708498024 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Histidine metabolism 0 0 0.414671815 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Linoleic acid metabolism 0.634782609 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Mannose type O-glycan biosynthesis -0.662608696 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Mucin type O-glycan biosynthesis 0.506956522 0 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 N-Glycan biosynthesis 0 0.730237154 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Nicotinate and nicotinamide metabolism 0 -0.703557312 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Nitrogen metabolism 0 -0.749011858 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 One carbon pool by folate 0 0.708498024 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Other glycan degradation 0 0 0.405920206 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Oxidative phosphorylation 0 0.447628458 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Pantothenate and CoA biosynthesis 0 -0.503952569 0 kegg kegg NA NA no no no no no dn Metabolism of xenobiotics by cytochrome P450 Pentose and glucuronate interconversions 0.693913043 0.872529644 0.51016731 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Phenylalanine metabolism 0.489565217 0.886363636 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Primary bile acid biosynthesis 0.515652174 0.649209486 0.511196911 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Propanoate metabolism 0.611304348 0.761857708 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Pyrimidine metabolism 0.551304348 0.695652174 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Pyruvate metabolism 0.540869565 0.795454545 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Retinol metabolism 0.685217391 0.65513834 0.518918919 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Sphingolipid metabolism 0 0 0.431917632 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Starch and sucrose metabolism 0 -0.491106719 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Steroid biosynthesis 0 0.700592885 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Steroid hormone biosynthesis 0.642608696 0.751976285 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Synthesis and degradation of ketone bodies 0 0.647233202 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Taurine and hypotaurine metabolism 0 -0.533596838 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Terpenoid backbone biosynthesis 0 0.424901186 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Thiamine metabolism 0 0.585968379 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Tryptophan metabolism 0.504347826 0.848814229 0.433976834 kegg kegg NA NA no no no no up no Metabolism of xenobiotics by cytochrome P450 Tyrosine metabolism 0.655652174 0.830039526 0.452252252 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Ubiquinone and other terpenoid-quinone biosynthesis 0.464347826 0.778656126 0 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 "Valine, leucine and isoleucine degradation" 0.486956522 0.875494071 0.526126126 kegg kegg NA NA no no no no no no Metabolism of xenobiotics by cytochrome P450 Various types of N-glycan biosynthesis 0 0.615612648 0 kegg kegg NA NA no no no no no no Methanosphaera Methanobrevibacter 0 0.700831113 0 Genus Genus 0.0703 0.629 no no no no no no MicroRNAs in cancer 2-Oxocarboxylic acid metabolism 0 -0.554347826 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer ABC transporters 0 0.43972332 0 kegg kegg NA NA no no no no up up MicroRNAs in cancer Adherens junction 0 -0.730237154 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Adipocytokine signaling pathway 0 0.637351779 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Adrenergic signaling in cardiomyocytes 0 -0.441699605 0 kegg kegg NA NA no no no no no up MicroRNAs in cancer African trypanosomiasis 0 0.476284585 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer AGE-RAGE signaling pathway in diabetic complications 0 0.794466403 0.692921493 kegg kegg NA NA no no no no no no MicroRNAs in cancer "Alanine, aspartate and glutamate metabolism" 0 0.701581028 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Aldosterone-regulated sodium reabsorption 0 0.625494071 0.702187902 kegg kegg NA NA no no no no no no MicroRNAs in cancer alpha-Linolenic acid metabolism 0 0.416996047 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Alzheimer disease 0 -0.624505929 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Amoebiasis 0 0.663043478 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Amphetamine addiction 0 -0.571146245 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Amyotrophic lateral sclerosis 0 -0.652173913 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Apelin signaling pathway 0 -0.692687747 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Apoptosis 0 0.677865613 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Arachidonic acid metabolism -0.54 0 -0.706821107 kegg kegg NA NA no no no no no no MicroRNAs in cancer Arginine and proline metabolism 0 0.733201581 0 kegg kegg NA NA no no no no up no MicroRNAs in cancer Arginine biosynthesis 0 0.647233202 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Autophagy - animal 0.525217391 0.927865613 0.678507079 kegg kegg NA NA no no no no no no MicroRNAs in cancer Autophagy - other 0 0.637351779 0.715572716 kegg kegg NA NA no no no no no no MicroRNAs in cancer Axon guidance 0 0 0.441956242 kegg kegg NA NA no no no no up up MicroRNAs in cancer B cell receptor signaling pathway 0.494782609 0.826086957 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Bacterial invasion of epithelial cells 0 -0.646245059 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Bacteroides 0 -0.424901186 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up MicroRNAs in cancer Basal transcription factors 0 0 0.436550837 kegg kegg NA NA no no no no no no MicroRNAs in cancer beta-Alanine metabolism 0 -0.550395257 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Bifidobacterium 0 -0.425954748 0 acetate-producing kegg Genus NA 0.105 no no no no dn no MicroRNAs in cancer Bile secretion 0 0 -0.442728443 kegg kegg NA NA no no no no no no MicroRNAs in cancer Biosynthesis of amino acids 0 0 -0.401287001 kegg kegg NA NA no no no no no no MicroRNAs in cancer Biosynthesis of cofactors 0 -0.46541502 -0.432175032 kegg kegg NA NA no no no no no no MicroRNAs in cancer Biosynthesis of unsaturated fatty acids 0 -0.473320158 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Butanoate metabolism 0 -0.764822134 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer C-type lectin receptor signaling pathway 0.503478261 0.855731225 0.472844273 kegg kegg NA NA no no no no no no MicroRNAs in cancer cAMP signaling pathway 0 0.529644269 0 yes kegg kegg NA NA no no no no up up MicroRNAs in cancer Carbohydrate digestion and absorption 0.466956522 0.736166008 0.74980695 kegg kegg NA NA no no no no no no MicroRNAs in cancer Cardiac muscle contraction 0 -0.600790514 0 kegg kegg NA NA no no no no no up MicroRNAs in cancer Cell cycle 0 0 0.528185328 kegg kegg NA NA no no no no no no MicroRNAs in cancer Cellular senescence 0 0.471343874 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer cGMP-PKG signaling pathway 0 0.429841897 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Chagas disease 0 0.795454545 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Chemokine signaling pathway 0 0.542490119 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Cholinergic synapse 0 0 0.593050193 kegg kegg NA NA no no no no no no MicroRNAs in cancer Circadian entrainment -0.423478261 -0.697628458 -0.479021879 kegg kegg NA NA no no no no up up MicroRNAs in cancer Circadian rhythm 0 0 0.666151866 kegg kegg NA NA no no no no no no MicroRNAs in cancer Citrate cycle (TCA cycle) 0 -0.77173913 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Collecting duct acid secretion 0 0 -0.517117117 kegg kegg NA NA no no no no no no MicroRNAs in cancer Collinsella -0.424717306 0 -0.507885269 kegg Genus NA 0.128 no no no no no no MicroRNAs in cancer Complement and coagulation cascades 0 0 -0.483655084 kegg kegg NA NA no no no no no no MicroRNAs in cancer Coronavirus disease - COVID-19 0 -0.623517787 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Cysteine and methionine metabolism 0 -0.746047431 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Cytokine-cytokine receptor interaction 0 0 -0.453281853 kegg kegg NA NA no no no no no no MicroRNAs in cancer Cytosolic DNA-sensing pathway 0 0.606719368 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer DNA replication 0 -0.675889328 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Dopaminergic synapse 0 -0.590909091 0 kegg kegg NA NA no no no no up no MicroRNAs in cancer Drug metabolism - cytochrome P450 0 -0.808300395 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Drug metabolism - other enzymes 0 -0.811264822 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer EGFR tyrosine kinase inhibitor resistance 0 -0.536561265 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Endocrine and other factor-regulated calcium reabsorption -0.408695652 -0.4743083 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Epithelial cell signaling in Helicobacter pylori infection 0 0.631422925 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer ErbB signaling pathway 0.420869565 0.708498024 0.871557272 kegg kegg NA NA no no no no no no MicroRNAs in cancer Estrogen signaling pathway 0 -0.68972332 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Fatty acid biosynthesis 0 0.641304348 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Fatty acid elongation 0 -0.584980237 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Fc epsilon RI signaling pathway 0 0.747035573 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Ferroptosis -0.464347826 0 -0.54028314 kegg kegg NA NA no no no no no no MicroRNAs in cancer Focal adhesion 0 -0.768774704 0 kegg kegg NA NA no no no no up up MicroRNAs in cancer FoxO signaling pathway 0.410434783 0.65513834 0.474388674 kegg kegg NA NA no no no no no no MicroRNAs in cancer Fructose and mannose metabolism 0 0.48715415 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer GABAergic synapse 0 0.548418972 0 kegg kegg NA NA no no no no up up MicroRNAs in cancer Galactose metabolism 0 0.447628458 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Gap junction 0 0 -0.44967825 kegg kegg NA NA no no no no no no MicroRNAs in cancer Gastric acid secretion 0 -0.780632411 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Glucagon signaling pathway 0 -0.549407115 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Glutathione metabolism -0.554782609 -0.556324111 -0.687773488 kegg kegg NA NA no no no no no no MicroRNAs in cancer Glycerolipid metabolism 0.495652174 0.511857708 0.492921493 kegg kegg NA NA no no no no no up MicroRNAs in cancer Glycerophospholipid metabolism 0 0.435770751 0.564736165 kegg kegg NA NA no no no no no up MicroRNAs in cancer "Glycine, serine and threonine metabolism" -0.406086957 0 0 kegg kegg NA NA no no no no up no MicroRNAs in cancer Glycolysis / Gluconeogenesis 0 -0.759881423 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.822134387 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.499011858 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Glyoxylate and dicarboxylate metabolism 0 0.649209486 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer GnRH secretion 0.414782609 0.735177866 0.779150579 kegg kegg NA NA no no no no up up MicroRNAs in cancer "Growth hormone synthesis, secretion and action" 0 0.51284585 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Hedgehog signaling pathway 0 0 0.749292149 kegg kegg NA NA no no no no no no MicroRNAs in cancer Hematopoietic cell lineage 0 -0.504940711 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Hepatitis B 0.528695652 0.927865613 0.646846847 kegg kegg NA NA no no no no no no MicroRNAs in cancer Hepatitis C 0.415652174 0.707509881 0.541055341 kegg kegg NA NA no no no no no no MicroRNAs in cancer HIF-1 signaling pathway 0 -0.603754941 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Hippo signaling pathway 0 -0.725296443 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Hippo signaling pathway - multiple species 0 0.709486166 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Human papillomavirus infection 0 0.51284585 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Huntington disease 0 -0.627470356 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Inflammatory mediator regulation of TRP channels 0 -0.616600791 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Inositol phosphate metabolism 0.575652174 0 0.538481338 kegg kegg NA NA no no no no no no MicroRNAs in cancer Insulin resistance 0.516521739 0.91798419 0.655341055 kegg kegg NA NA no no no no no no MicroRNAs in cancer Insulin signaling pathway 0 -0.608695652 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer JAK-STAT signaling pathway 0.565217391 0.829051383 0.437065637 kegg kegg NA NA no no no no no no MicroRNAs in cancer Kaposi sarcoma-associated herpesvirus infection 0 0 -0.464350064 kegg kegg NA NA no no no no no dn MicroRNAs in cancer Lachnospira 0 -0.557944173 0 butyrate-producing kegg Genus NA 0.279 no no no no no no MicroRNAs in cancer Leishmaniasis 0 -0.470355731 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Long-term potentiation 0 -0.530632411 0.539253539 kegg kegg NA NA no no no no no up MicroRNAs in cancer Lysine degradation 0.422608696 0 0.61003861 kegg kegg NA NA no no no no no no MicroRNAs in cancer Malaria -0.63826087 0 -0.491377091 kegg kegg NA NA no no no no no no MicroRNAs in cancer Mannose type O-glycan biosynthesis 0 0 0.566795367 kegg kegg NA NA no no no no no no MicroRNAs in cancer MAPK signaling pathway 0.509565217 0 0.728442728 kegg kegg NA NA no no no no no no MicroRNAs in cancer Measles 0.417391304 0 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Melanogenesis 0 -0.580039526 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Metabolism of xenobiotics by cytochrome P450 0 -0.833003953 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Mineral absorption -0.463478261 0 -0.551866152 kegg kegg NA NA no no no no no no MicroRNAs in cancer Mismatch repair 0 -0.614624506 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Mitophagy - animal 0 0 -0.433204633 kegg kegg NA NA no no no no no no MicroRNAs in cancer mRNA surveillance pathway 0 0 0.595366795 kegg kegg NA NA no no no no no no MicroRNAs in cancer mTOR signaling pathway 0 -0.507905138 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer N-Glycan biosynthesis 0 -0.603754941 0.401287001 kegg kegg NA NA no no no no no no MicroRNAs in cancer Necroptosis -0.454782609 0 -0.518661519 kegg kegg NA NA no no no no no no MicroRNAs in cancer Neurotrophin signaling pathway 0 0.789525692 0.433204633 kegg kegg NA NA no no no no no no MicroRNAs in cancer Neutrophil extracellular trap formation 0 0 -0.435006435 kegg kegg NA NA no no no no no no MicroRNAs in cancer NF-kappa B signaling pathway 0.485217391 0.931818182 0.470785071 kegg kegg NA NA no no no no no no MicroRNAs in cancer Nicotinate and nicotinamide metabolism 0 0.662055336 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Nitrogen metabolism 0 0.641304348 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer NOD-like receptor signaling pathway 0 0.796442688 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Non-alcoholic fatty liver disease 0 -0.510869565 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Non-homologous end-joining 0 -0.659090909 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Notch signaling pathway 0 0.54743083 0.568082368 kegg kegg NA NA no no no no no no MicroRNAs in cancer Nucleotide excision repair 0 -0.580039526 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer One carbon pool by folate 0 -0.600790514 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Oocyte meiosis 0 -0.665019763 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Osteoclast differentiation 0.42173913 0.656126482 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Other glycan degradation 0.424347826 0.503952569 0.450707851 kegg kegg NA NA no no no no no no MicroRNAs in cancer Other types of O-glycan biosynthesis 0 0 0.643758044 kegg kegg NA NA no no no no no no MicroRNAs in cancer Oxidative phosphorylation 0 -0.622529644 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Oxytocin signaling pathway 0 -0.578063241 -0.565508366 kegg kegg NA NA no no no no no no MicroRNAs in cancer p53 signaling pathway 0 0 0.489060489 kegg kegg NA NA no no no no no no MicroRNAs in cancer Pancreatic secretion 0 -0.461462451 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Pantothenate and CoA biosynthesis 0 0.541501976 0 kegg kegg NA NA no no no no no dn MicroRNAs in cancer Paraprevotella -0.40680091 0 0 kegg Genus NA 0.118 no no no no no no MicroRNAs in cancer Parkinson disease 0 -0.550395257 -0.482368082 kegg kegg NA NA no no no no no no MicroRNAs in cancer Pathogenic Escherichia coli infection 0 0 -0.451480051 kegg kegg NA NA no no no no no no MicroRNAs in cancer Pathways in cancer 0 0.786561265 0.545945946 kegg kegg NA NA no no no no no no MicroRNAs in cancer Pathways of neurodegeneration - multiple diseases 0 -0.529644269 -0.491119691 kegg kegg NA NA no no no no no no MicroRNAs in cancer Pentose and glucuronate interconversions 0 -0.701581028 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Peroxisome 0 0.473320158 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Phenylalanine metabolism 0 -0.750988142 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Phosphatidylinositol signaling system 0 0 0.695495495 kegg kegg NA NA no no no no no no MicroRNAs in cancer Phospholipase D signaling pathway 0 0.723320158 0 kegg kegg NA NA no no no no up up MicroRNAs in cancer Phototransduction 0 -0.769762846 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer PI3K-Akt signaling pathway 0.509565217 0 0 yes kegg kegg NA NA no no no no up up MicroRNAs in cancer Platelet activation 0 -0.685770751 -0.425997426 kegg kegg NA NA no no no no no no MicroRNAs in cancer Platinum drug resistance 0 0 0.520978121 kegg kegg NA NA no no no no no no MicroRNAs in cancer Porphyrin and chlorophyll metabolism -0.487826087 0 -0.462290862 kegg kegg NA NA no no no no no no MicroRNAs in cancer PPAR signaling pathway 0 0.599802372 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Primary bile acid biosynthesis 0 -0.630434783 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Prion disease 0 -0.681818182 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Progesterone-mediated oocyte maturation 0.473043478 0 0.705276705 kegg kegg NA NA no no no no no no MicroRNAs in cancer Prolactin signaling pathway 0 0.720355731 0.536164736 kegg kegg NA NA no no no no no no MicroRNAs in cancer Propanoate metabolism 0 -0.736166008 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Proteasome 0 -0.707509881 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Protein digestion and absorption 0 0.479249012 0.446846847 yes kegg kegg NA NA no no no no up up MicroRNAs in cancer Protein export 0 -0.624505929 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Protein processing in endoplasmic reticulum 0 -0.541501976 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Proteoglycans in cancer 0 -0.585968379 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Proximal tubule bicarbonate reclamation 0 -0.633399209 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Purine metabolism -0.430434783 0 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Pyrimidine metabolism 0 -0.589920949 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Pyruvate metabolism 0 -0.781620553 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Rap1 signaling pathway 0 -0.493083004 -0.422651223 kegg kegg NA NA no no no no no no MicroRNAs in cancer Ras signaling pathway 0 -0.585968379 0.429086229 yes kegg kegg NA NA no no no no up up MicroRNAs in cancer Regulation of actin cytoskeleton 0 -0.658102767 -0.46023166 kegg kegg NA NA no no no no no no MicroRNAs in cancer Relaxin signaling pathway 0 0.64229249 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Renin secretion -0.463478261 -0.725296443 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Retinol metabolism 0 -0.546442688 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Retrograde endocannabinoid signaling 0 -0.679841897 0 kegg kegg NA NA no no no no no up MicroRNAs in cancer Ribosome 0 -0.635375494 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Ribosome biogenesis in eukaryotes 0 0 0.446332046 kegg kegg NA NA no no no no no no MicroRNAs in cancer RIG-I-like receptor signaling pathway 0 0.93083004 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer RNA degradation 0 -0.483201581 0.6 kegg kegg NA NA no no no no no no MicroRNAs in cancer RNA polymerase 0 -0.47826087 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer RNA transport 0 -0.496047431 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Ruminococcus 0 -0.416048824 0 kegg Genus NA 0.0679 no no no no no dn MicroRNAs in cancer Ruminococcus -0.424347826 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no MicroRNAs in cancer Salivary secretion 0 -0.484189723 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Selenocompound metabolism 0 0 0.461518662 kegg kegg NA NA no no no no no no MicroRNAs in cancer Serotonergic synapse 0 0 -0.43963964 kegg kegg NA NA no no no no no no MicroRNAs in cancer Shigellosis 0 0 -0.566537967 kegg kegg NA NA no no no no no no MicroRNAs in cancer Signaling pathways regulating pluripotency of stem cells 0 0.502964427 0.832947233 kegg kegg NA NA no no no no no no MicroRNAs in cancer SNARE interactions in vesicular transport 0.433043478 0.67687747 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Sphingolipid signaling pathway 0 0.518774704 0.561904762 kegg kegg NA NA no no no no no no MicroRNAs in cancer Spinocerebellar ataxia 0 0 0.546203346 kegg kegg NA NA no no no no no no MicroRNAs in cancer Spliceosome 0 0 0.620849421 kegg kegg NA NA no no no no no no MicroRNAs in cancer Staphylococcus aureus infection 0 0 -0.411325611 kegg kegg NA NA no no no up no no MicroRNAs in cancer Starch and sucrose metabolism 0 0.535573123 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Steroid biosynthesis 0 -0.654150198 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Steroid hormone biosynthesis 0 -0.639328063 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Sulfur metabolism 0 0 -0.497812098 kegg kegg NA NA no no no no no no MicroRNAs in cancer Synthesis and degradation of ketone bodies 0 -0.584980237 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer T cell receptor signaling pathway 0.484347826 0.643280632 0.524581725 kegg kegg NA NA no no no no no no MicroRNAs in cancer Taste transduction 0 -0.493083004 0.51042471 kegg kegg NA NA no no no no no up MicroRNAs in cancer Taurine and hypotaurine metabolism 0 0.644268775 0.54002574 kegg kegg NA NA no no no no no no MicroRNAs in cancer TGF-beta signaling pathway 0 -0.590909091 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Th17 cell differentiation 0 0.438735178 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Thermogenesis 0 -0.690711462 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Thiamine metabolism 0 -0.603754941 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Thyroid hormone signaling pathway 0 -0.565217391 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Thyroid hormone synthesis -0.442608696 0 -0.51042471 kegg kegg NA NA no no no no no no MicroRNAs in cancer Tight junction 0 -0.71541502 -0.658687259 kegg kegg NA NA no no no no no no MicroRNAs in cancer TNF signaling pathway 0 0.903162055 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Toll-like receptor signaling pathway 0.433043478 0.806324111 0 yes kegg kegg NA NA no no no no no no MicroRNAs in cancer Transcriptional misregulation in cancer 0.454782609 0.915019763 0.619047619 kegg kegg NA NA no no no no no no MicroRNAs in cancer Tryptophan metabolism 0 -0.675889328 0 kegg kegg NA NA no no no no up no MicroRNAs in cancer Type II diabetes mellitus 0.574782609 0.866600791 0.657142857 kegg kegg NA NA no no no no no no MicroRNAs in cancer Tyrosine metabolism 0 -0.778656126 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.599802372 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Ubiquitin mediated proteolysis 0 0 -0.455341055 kegg kegg NA NA no no no no no no MicroRNAs in cancer "Valine, leucine and isoleucine degradation" 0 -0.7243083 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Various types of N-glycan biosynthesis 0 -0.459486166 0.444272844 kegg kegg NA NA no no no no no no MicroRNAs in cancer Vascular smooth muscle contraction 0 -0.692687747 -0.416988417 kegg kegg NA NA no no no no no no MicroRNAs in cancer Vasopressin-regulated water reabsorption 0 -0.536561265 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer VEGF signaling pathway 0.426086957 0.661067194 0.711711712 kegg kegg NA NA no no no no no no MicroRNAs in cancer Vibrio cholerae infection 0 -0.708498024 -0.499356499 kegg kegg NA NA no no no no no no MicroRNAs in cancer Viral carcinogenesis 0 0.548418972 0 kegg kegg NA NA no no no no no no MicroRNAs in cancer Viral protein interaction with cytokine and cytokine receptor 0 0 -0.684942085 kegg kegg NA NA no no no no no no MicroRNAs in cancer Wnt signaling pathway 0 -0.507905138 0.606949807 kegg kegg NA NA no no no no no no Mineral absorption 2-Oxocarboxylic acid metabolism 0 0 -0.425740026 kegg kegg NA NA no no no no no no Mineral absorption ABC transporters -0.552173913 0 0 kegg kegg NA NA no no no no up up Mineral absorption Adipocytokine signaling pathway 0.568695652 0 0.650965251 kegg kegg NA NA no no no no no no Mineral absorption Adrenergic signaling in cardiomyocytes 0.60173913 0.59486166 0 kegg kegg NA NA no no no no no up Mineral absorption AGE-RAGE signaling pathway in diabetic complications 0 0 -0.477992278 kegg kegg NA NA no no no no no no Mineral absorption Aldosterone synthesis and secretion 0.624347826 0.587944664 0 kegg kegg NA NA no no no no up up Mineral absorption Aldosterone-regulated sodium reabsorption 0 0 -0.515830116 kegg kegg NA NA no no no no no no Mineral absorption alpha-Linolenic acid metabolism -0.419130435 -0.48715415 -0.469240669 kegg kegg NA NA no no no no no no Mineral absorption Amino sugar and nucleotide sugar metabolism -0.427826087 0 0 kegg kegg NA NA no no no no no no Mineral absorption Aminoacyl-tRNA biosynthesis -0.489565217 0 0 kegg kegg NA NA no no no no no no Mineral absorption AMPK signaling pathway 0.509565217 0.46541502 0.654568855 kegg kegg NA NA no no no no no no Mineral absorption Arachidonic acid metabolism 0 0 0.503989704 kegg kegg NA NA no no no no no no Mineral absorption Ascorbate and aldarate metabolism 0 0 -0.435778636 kegg kegg NA NA no no no no no no Mineral absorption Autophagy - animal 0 0 -0.40952381 kegg kegg NA NA no no no no no no Mineral absorption beta-Alanine metabolism -0.457391304 -0.475296443 0 kegg kegg NA NA no no no no no no Mineral absorption Bile secretion 0.74173913 0.650197628 0.630888031 kegg kegg NA NA no no no no no no Mineral absorption Biosynthesis of cofactors 0 0 0.549292149 kegg kegg NA NA no no no no no no Mineral absorption Biosynthesis of unsaturated fatty acids -0.584347826 -0.571146245 0 kegg kegg NA NA no no no no no no Mineral absorption Calcium signaling pathway 0.469565217 0.662055336 0 kegg kegg NA NA no no no no up up Mineral absorption cAMP signaling pathway 0.433043478 0.457509881 0 yes kegg kegg NA NA no no no no up up Mineral absorption Carbohydrate digestion and absorption 0 0 -0.588159588 kegg kegg NA NA no no no no no no Mineral absorption Carbon metabolism -0.416521739 -0.47826087 0 kegg kegg NA NA no no no no no no Mineral absorption Cardiac muscle contraction 0 0.60770751 0 kegg kegg NA NA no no no no no up Mineral absorption Cholinergic synapse 0 0 -0.512741313 kegg kegg NA NA no no no no no no Mineral absorption Circadian entrainment 0.552173913 0 0.534620335 kegg kegg NA NA no no no no up up Mineral absorption Citrate cycle (TCA cycle) -0.428695652 0 0 kegg kegg NA NA no no no no no no Mineral absorption Complement and coagulation cascades 0 -0.418972332 0 kegg kegg NA NA no no no no no no Mineral absorption Cortisol synthesis and secretion 0.691304348 0.669960474 0 kegg kegg NA NA no no no no no up Mineral absorption Cushing syndrome 0.572173913 0.579051383 0 kegg kegg NA NA no no no no no up Mineral absorption Cytokine-cytokine receptor interaction 0 -0.479249012 0 kegg kegg NA NA no no no no no no Mineral absorption DNA replication -0.42173913 0 0 kegg kegg NA NA no no no no no no Mineral absorption Dopaminergic synapse 0.596521739 0.446640316 0 kegg kegg NA NA no no no no up no Mineral absorption Endocrine and other factor-regulated calcium reabsorption 0.673043478 0.662055336 0.509395109 kegg kegg NA NA no no no no no no Mineral absorption Endocrine resistance 0.500869565 0.464426877 0 kegg kegg NA NA no no no no no no Mineral absorption Endocytosis 0 -0.424901186 0 kegg kegg NA NA no no no no no no Mineral absorption ErbB signaling pathway 0 0 -0.65045045 kegg kegg NA NA no no no no no no Mineral absorption Fanconi anemia pathway -0.470434783 0 0 kegg kegg NA NA no no no no no no Mineral absorption Fatty acid degradation -0.572173913 -0.596837945 0 kegg kegg NA NA no no no no no no Mineral absorption Fatty acid elongation -0.485217391 -0.533596838 0 kegg kegg NA NA no no no no no no Mineral absorption Fatty acid metabolism -0.606956522 -0.641304348 0 kegg kegg NA NA no no no no no no Mineral absorption Fc gamma R-mediated phagocytosis -0.604347826 -0.557312253 0 kegg kegg NA NA no no no no no no Mineral absorption Ferroptosis 0.869565217 0.779644269 0.93976834 kegg kegg NA NA no no no no no no Mineral absorption FoxO signaling pathway 0 -0.506916996 0 kegg kegg NA NA no no no no no no Mineral absorption Galactose metabolism -0.553043478 -0.58201581 -0.425482625 kegg kegg NA NA no no no no no no Mineral absorption Gap junction 0.519130435 0.545454545 0 kegg kegg NA NA no no no no no no Mineral absorption Glucagon signaling pathway 0.5 0.480237154 0 kegg kegg NA NA no no no no no no Mineral absorption Glutamatergic synapse 0.514782609 0 0.431145431 kegg kegg NA NA no no no no up up Mineral absorption Glutathione metabolism 0.484347826 0.464426877 0.621106821 kegg kegg NA NA no no no no no no Mineral absorption Glycerolipid metabolism -0.423478261 0 -0.61029601 kegg kegg NA NA no no no no no up Mineral absorption Glycerophospholipid metabolism 0 0 -0.483655084 kegg kegg NA NA no no no no no up Mineral absorption "Glycine, serine and threonine metabolism" 0 0 0.56010296 kegg kegg NA NA no no no no up no Mineral absorption Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.478249678 kegg kegg NA NA no no no no no no Mineral absorption Glycosaminoglycan biosynthesis - keratan sulfate 0.448695652 0 0 kegg kegg NA NA no no no no no no Mineral absorption Glycosaminoglycan degradation 0 0 -0.539253539 kegg kegg NA NA no no no no no up Mineral absorption Glyoxylate and dicarboxylate metabolism -0.445217391 0 0 kegg kegg NA NA no no no no no no Mineral absorption GnRH secretion 0 0 -0.519433719 kegg kegg NA NA no no no no up up Mineral absorption GnRH signaling pathway 0.649565217 0.602766798 0 kegg kegg NA NA no no no no no no Mineral absorption Hedgehog signaling pathway 0 0 -0.517117117 kegg kegg NA NA no no no no no no Mineral absorption Hematopoietic cell lineage 0 -0.419960474 0 kegg kegg NA NA no no no no no no Mineral absorption Hippo signaling pathway - multiple species 0 0 -0.486743887 kegg kegg NA NA no no no no no no Mineral absorption Histidine metabolism -0.426956522 -0.416007905 0 kegg kegg NA NA no no no no no no Mineral absorption Homologous recombination -0.532173913 0 0 kegg kegg NA NA no no no no no no Mineral absorption Inflammatory mediator regulation of TRP channels 0.570434783 0 0 kegg kegg NA NA no no no no no no Mineral absorption Inositol phosphate metabolism -0.527826087 0 -0.561647362 kegg kegg NA NA no no no no no no Mineral absorption Insulin secretion 0.610434783 0.657114625 0 yes kegg kegg NA NA no no no no up up Mineral absorption Long-term depression 0.723478261 0.640316206 0 kegg kegg NA NA no no no no no no Mineral absorption Longevity regulating pathway 0.6 0 0.638867439 kegg kegg NA NA no no no no no no Mineral absorption Longevity regulating pathway - multiple species -0.426086957 -0.690711462 0 kegg kegg NA NA no no no no no no Mineral absorption Lysine degradation 0 0 -0.470527671 kegg kegg NA NA no no no no no no Mineral absorption Mannose type O-glycan biosynthesis 0 0 -0.4002574 kegg kegg NA NA no no no no no no Mineral absorption MAPK signaling pathway -0.449565217 -0.4743083 -0.585585586 kegg kegg NA NA no no no no no no Mineral absorption Melanogenesis 0.563478261 0.516798419 0 kegg kegg NA NA no no no no no no Mineral absorption Mismatch repair -0.496521739 0 0 kegg kegg NA NA no no no no no no Mineral absorption Mitophagy - animal 0.855652174 0.77173913 0.807979408 kegg kegg NA NA no no no no no no Mineral absorption Mucin type O-glycan biosynthesis -0.447826087 -0.475296443 0 kegg kegg NA NA no no no no no no Mineral absorption N-Glycan biosynthesis 0 0 -0.436550837 kegg kegg NA NA no no no no no no Mineral absorption Necroptosis 0.947826087 0.920948617 0.959330759 kegg kegg NA NA no no no no no no Mineral absorption Neuroactive ligand-receptor interaction -0.435652174 -0.606719368 0 kegg kegg NA NA no no no up up up Mineral absorption NF-kappa B signaling pathway -0.584347826 0 0 kegg kegg NA NA no no no no no no Mineral absorption NOD-like receptor signaling pathway -0.522608696 0 0 kegg kegg NA NA no no no no no no Mineral absorption Non-alcoholic fatty liver disease 0.464347826 0.659090909 0 kegg kegg NA NA no no no no no no Mineral absorption Non-homologous end-joining -0.519130435 -0.43083004 0 kegg kegg NA NA no no no no no no Mineral absorption Notch signaling pathway 0 0 -0.527670528 kegg kegg NA NA no no no no no no Mineral absorption Nucleotide excision repair -0.434782609 0 0 kegg kegg NA NA no no no no no no Mineral absorption Osteoclast differentiation -0.433913043 -0.416007905 0 kegg kegg NA NA no no no no no no Mineral absorption Other glycan degradation -0.408695652 0 -0.689317889 kegg kegg NA NA no no no no no no Mineral absorption Other types of O-glycan biosynthesis 0 0 -0.51016731 kegg kegg NA NA no no no no no no Mineral absorption Ovarian steroidogenesis 0.564347826 0.673913043 0.531274131 kegg kegg NA NA no no no no up up Mineral absorption Oxidative phosphorylation 0.406956522 0.588932806 0 kegg kegg NA NA no no no no no no Mineral absorption Pancreatic secretion 0.679130435 0.610671937 0 kegg kegg NA NA no no no no no no Mineral absorption Pantothenate and CoA biosynthesis -0.426956522 -0.495059289 0 kegg kegg NA NA no no no no no dn Mineral absorption "Parathyroid hormone synthesis, secretion and action" 0.623478261 0.745059289 0.534362934 kegg kegg NA NA no no no no no no Mineral absorption Peroxisome -0.469565217 -0.498023715 0 kegg kegg NA NA no no no no no no Mineral absorption Phosphatidylinositol signaling system 0 0 -0.491634492 kegg kegg NA NA no no no no no no Mineral absorption Porphyrin and chlorophyll metabolism 0.457391304 0 0.61981982 kegg kegg NA NA no no no no no no Mineral absorption Primary bile acid biosynthesis -0.543478261 -0.424901186 0 kegg kegg NA NA no no no no no no Mineral absorption Progesterone-mediated oocyte maturation 0 0 -0.581467181 kegg kegg NA NA no no no no no no Mineral absorption Protein digestion and absorption -0.477391304 -0.648221344 -0.439124839 yes kegg kegg NA NA no no no no up up Mineral absorption Protein processing in endoplasmic reticulum 0 0 0.508622909 kegg kegg NA NA no no no no no no Mineral absorption Purine metabolism 0.453913043 0 0.746460746 kegg kegg NA NA no no no no no no Mineral absorption Regulation of lipolysis in adipocytes 0.691304348 0.654150198 0.444530245 kegg kegg NA NA no no no no no no Mineral absorption Relaxin signaling pathway 0.484347826 0.455533597 0 kegg kegg NA NA no no no no no no Mineral absorption Renin secretion 0.565217391 0 0.534620335 kegg kegg NA NA no no no no no no Mineral absorption Renin-angiotensin system 0 -0.445652174 0 kegg kegg NA NA no no no no no no Mineral absorption Retinol metabolism -0.462608696 0 0 kegg kegg NA NA no no no no no no Mineral absorption Retrograde endocannabinoid signaling 0 0.494071146 0 kegg kegg NA NA no no no no no up Mineral absorption Ribosome 0.586086957 0.523715415 0 kegg kegg NA NA no no no no no no Mineral absorption RNA degradation 0 0 -0.434234234 kegg kegg NA NA no no no no no no Mineral absorption Salivary secretion 0.447826087 0 0.438352638 kegg kegg NA NA no no no no no no Mineral absorption Selenocompound metabolism 0 0 -0.458944659 kegg kegg NA NA no no no no no no Mineral absorption Signaling pathways regulating pluripotency of stem cells 0 0 -0.502187902 kegg kegg NA NA no no no no no no Mineral absorption SNARE interactions in vesicular transport -0.473913043 0 0 kegg kegg NA NA no no no no no no Mineral absorption Sphingolipid signaling pathway 0 0 -0.553410553 kegg kegg NA NA no no no no no no Mineral absorption Spliceosome 0 0 -0.403603604 kegg kegg NA NA no no no no no no Mineral absorption Starch and sucrose metabolism -0.414782609 -0.447628458 0 kegg kegg NA NA no no no no no no Mineral absorption Sulfur metabolism 0 0 0.449163449 kegg kegg NA NA no no no no no no Mineral absorption Taste transduction 0 0 -0.56962677 kegg kegg NA NA no no no no no up Mineral absorption Terpenoid backbone biosynthesis 0 -0.428853755 0 kegg kegg NA NA no no no no no no Mineral absorption Th1 and Th2 cell differentiation 0 0 -0.472586873 kegg kegg NA NA no no no no no no Mineral absorption Th17 cell differentiation 0 0 -0.476705277 kegg kegg NA NA no no no no no no Mineral absorption Thermogenesis 0.482608696 0.550395257 0 kegg kegg NA NA no no no no no no Mineral absorption Thyroid hormone synthesis 0.613913043 0.731225296 0.648906049 kegg kegg NA NA no no no no no no Mineral absorption Tryptophan metabolism -0.445217391 -0.500988142 0 kegg kegg NA NA no no no no up no Mineral absorption Type II diabetes mellitus 0 0 -0.499356499 kegg kegg NA NA no no no no no no Mineral absorption Ubiquinone and other terpenoid-quinone biosynthesis -0.423478261 0 0 kegg kegg NA NA no no no no no no Mineral absorption Ubiquitin mediated proteolysis 0.780869565 0.716403162 0.7997426 kegg kegg NA NA no no no no no no Mineral absorption "Valine, leucine and isoleucine degradation" -0.455652174 0 0 kegg kegg NA NA no no no no no no Mineral absorption Various types of N-glycan biosynthesis 0 0 -0.578120978 kegg kegg NA NA no no no no no no Mineral absorption Vascular smooth muscle contraction 0.719130435 0.470355731 0.566537967 kegg kegg NA NA no no no no no no Mineral absorption Vasopressin-regulated water reabsorption 0.646956522 0.643280632 0.522265122 kegg kegg NA NA no no no no no no Mineral absorption VEGF signaling pathway 0 0 -0.538223938 kegg kegg NA NA no no no no no no Mineral absorption Wnt signaling pathway 0 0 -0.457400257 kegg kegg NA NA no no no no no no MIP-1a IFN-g 0 -0.479220779 0 serum_cytokines serum_cytokines 0.68 0.825 no no no no no no MIP-1a IL-2 0 0 -0.634260289 serum_cytokines serum_cytokines 0.68 0.522 no no no no no no MIP-1a IL-6 0 0 -0.542602892 serum_cytokines serum_cytokines 0.68 0.52 no no no no no no MIP-1a IL-8 0 0 -0.42647386 serum_cytokines serum_cytokines 0.68 0.579 no no no no no no MIP-1a IP-10 0 0.574025974 0 serum_cytokines serum_cytokines 0.68 0.394 no no no no no no MIP-1b 12-ketoDCA+blood 0 0.679066556 0 serum_cytokines serum_bileacids 0.632 0.517 no no no no no no MIP-1b 14:0/16:0-PC+blood 0 0 0.445112782 serum_cytokines serum_phospholipids 0.632 0.0358 no no no no up no MIP-1b 14:0/20:4-PC+blood 0 0 0.484210526 serum_cytokines serum_phospholipids 0.632 0.486 no no no no no no MIP-1b 16:0/16:1-PC+blood 0 0 0.514285714 serum_cytokines serum_phospholipids 0.632 0.00283 no no no up up no MIP-1b 16:0/18:3-PC+blood 0 0 0.708270677 serum_cytokines serum_phospholipids 0.632 0.00216 no no no no up up MIP-1b 16:0/22:6-PE+blood 0.709090909 0 0 serum_cytokines serum_phospholipids 0.632 0.000934 no no no up up no MIP-1b 18:1/18:1-PE+blood 0.939393939 0 0 serum_cytokines serum_phospholipids 0.632 1.03E-05 no no no up up no MIP-1b 20:2+blood 0 0 -0.494736842 serum_cytokines serum_fattyacid 0.632 0.478 no no no no no no MIP-1b 20:4/18:0-PE+blood 0.757575758 0 0 serum_cytokines serum_phospholipids 0.632 0.000755 no no no up up no MIP-1b 9-HODE+blood 0 0 0.463157895 serum_cytokines serum_ARA 0.632 0.297 no no no no no no MIP-1b Adrenergic signaling in cardiomyocytes -0.741758242 0 0.490968801 serum_cytokines kegg 0.632 NA no no no no no up MIP-1b Akkermansia 0 0 -0.401073732 acetate-producing serum_cytokines Genus 0.632 0.23 no no no no no no MIP-1b Alcoholism -0.554945055 -0.472180451 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Aldosterone synthesis and secretion -0.620879121 0 0.447181171 serum_cytokines kegg 0.632 NA no no no no up up MIP-1b Amphetamine addiction 0 0 0.417624521 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Antigen processing and presentation 0 -0.568421053 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Apoptosis 0 0 -0.585659551 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Betaine+blood -0.636363636 0 0 serum_cytokines serum_choline 0.632 0.857 no no no no no no MIP-1b Biosynthesis of amino acids 0 -0.445112782 -0.506294472 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Blautia 0 -0.449350649 0 acetate-producing serum_cytokines Genus 0.632 1.36E-05 no no no up dn dn MIP-1b CA+blood 0 0 0.496983959 serum_cytokines serum_bileacids 0.632 0.606 no no no no no no MIP-1b Calcium signaling pathway -0.604395604 0 0 serum_cytokines kegg 0.632 NA no no no no up up MIP-1b Carbon metabolism 0 -0.535338346 -0.556102901 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Cell cycle 0 0 0.469074986 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Chemical carcinogenesis - receptor activation 0 0.490225564 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Choline metabolism in cancer 0 0.461654135 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Chronic myeloid leukemia 0 0.454135338 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Clostridium 0.574594405 -0.595809451 0 serum_cytokines Genus 0.632 0.925 no no no no no no MIP-1b Colorectal cancer 0 0.467669173 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Cushing syndrome 0 0.479699248 0.435686918 serum_cytokines kegg 0.632 NA no no no no no up MIP-1b Cysteine+blood -0.660606061 0 -0.606015038 yes serum_cytokines serum_aminoacids 0.632 1.81E-07 no no no dn up up MIP-1b d18:1-20:0-SM+blood 0.721212121 0 0 serum_cytokines serum_phospholipids 0.632 0.933 no no no no no no MIP-1b DCA+stool 0 0.769230769 0 serum_cytokines stool_bileacids 0.632 0.195 no no no no no no MIP-1b Dopaminergic synapse 0 0 0.455391352 serum_cytokines kegg 0.632 NA no no no no up no MIP-1b Eotaxin 0 0.476623377 0.498998888 serum_cytokines serum_cytokines 0.632 0.393 no no no no no no MIP-1b Epstein-Barr virus infection 0 -0.530827068 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b ErbB signaling pathway 0 0.526315789 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Faecalibacterium -0.582417582 0 0 butyrate-producing serum_cytokines Genus 0.632 0.0039 no no no no dn dn MIP-1b Fc gamma R-mediated phagocytosis 0 0 -0.477285167 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Ferroptosis -0.571428571 0 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Fluid shear stress and atherosclerosis 0 -0.476691729 -0.522714833 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Gastric cancer 0 0.687218045 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b GCA+stool 0 -0.769230769 0.517156863 serum_cytokines stool_bileacids 0.632 0.0809 no no no no no no MIP-1b GCDCA+stool 0 0 0.598039216 yes serum_cytokines stool_bileacids 0.632 0.0471 no no no no dn no MIP-1b GDCA+blood 0 0 -0.539849624 serum_cytokines serum_bileacids 0.632 0.632 no no no no no no MIP-1b GDCA+stool 0 0 0.484030945 serum_cytokines stool_bileacids 0.632 0.656 no no no no no no MIP-1b GLCA+blood 0 0.537276633 0 serum_cytokines serum_bileacids 0.632 0.319 no no no no no no MIP-1b Glucagon signaling pathway -0.554945055 0 0.549534756 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Glutamatergic synapse -0.56043956 0 0 serum_cytokines kegg 0.632 NA no no no no up up MIP-1b GM-CSF 0 -0.445454545 -0.647608454 yes serum_cytokines serum_cytokines 0.632 0.0124 no no no up no no MIP-1b HDCA+blood 0 0 -0.445082418 serum_cytokines serum_bileacids 0.632 0.483 no no no no no no MIP-1b Herpes simplex virus 1 infection 0 -0.467669173 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Homovanillic acid+urine 0 -0.597058824 0 serum_cytokines urine_cometabolism 0.632 0.45 no no no no no no MIP-1b Human cytomegalovirus infection 0 -0.47518797 0 serum_cytokines kegg 0.632 NA no no no no no dn MIP-1b Human immunodeficiency virus 1 infection 0 -0.506766917 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Human T-cell leukemia virus 1 infection 0 -0.518796992 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b IFN-g 0 -0.712987013 -0.409121246 serum_cytokines serum_cytokines 0.632 0.825 no no no no no no MIP-1b IL-17 signaling pathway 0 0 -0.534209086 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b IL-1b 0 0 -0.441156841 yes serum_cytokines serum_cytokines 0.632 0.00358 no no no up up no MIP-1b IL-2 -0.813186813 -0.680519481 -0.560845384 serum_cytokines serum_cytokines 0.632 0.522 no no no no no no MIP-1b IL-6 0 -0.687012987 0 serum_cytokines serum_cytokines 0.632 0.52 no no no no no no MIP-1b IL-8 -0.60989011 -0.577922078 -0.63025584 serum_cytokines serum_cytokines 0.632 0.579 no no no no no no MIP-1b IL-9 0.774725275 0.94025974 0.778865406 serum_cytokines serum_cytokines 0.632 0.906 no no no no no no MIP-1b Inflammatory mediator regulation of TRP channels 0 0 0.45210728 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Influenza A 0 0 -0.488232074 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b IP-10 0 0.453246753 0 serum_cytokines serum_cytokines 0.632 0.394 no no no no no no MIP-1b iso-LCA+blood 0 0.557068665 0 serum_cytokines serum_bileacids 0.632 0.507 no no no no no no MIP-1b iso-LCA+stool 0 0.832167832 0 serum_cytokines stool_bileacids 0.632 0.72 no no no no no no MIP-1b L-Arginine+blood -0.818181818 0 0 serum_cytokines serum_aminoacids 0.632 0.316 no no no no no no MIP-1b L-Methionine+blood -0.866666667 0 0 serum_cytokines serum_aminoacids 0.632 0.626 no no no no no no MIP-1b L-Phenylalanine+blood -0.842424242 0 0 yes serum_cytokines serum_aminoacids 0.632 0.0103 no no no up up no MIP-1b L-Phenylalanine+stool 0.781818182 0 0 serum_cytokines stool_cometabolism 0.632 0.398 no no no no no no MIP-1b L-Tryptophan+blood -0.696969697 0 0 serum_cytokines serum_aminoacids 0.632 0.164 no no no no no no MIP-1b L-Tryptophan+stool 0.721212121 0 0 serum_cytokines stool_cometabolism 0.632 0.557 no no no no no no MIP-1b L-Tyrosine+blood -0.781818182 0 0 yes serum_cytokines serum_aminoacids 0.632 0.00913 no no no up up no MIP-1b L-Tyrosine+stool 0.672727273 0 0 serum_cytokines stool_cometabolism 0.632 0.44 no no no no no no MIP-1b LCA+stool 0 0.797202797 0 serum_cytokines stool_bileacids 0.632 0.314 no no no no no no MIP-1b Leukocyte transendothelial migration 0 -0.530827068 -0.419813903 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Lipid and atherosclerosis 0 0 -0.455391352 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Longevity regulating pathway -0.686813187 0 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Longevity regulating pathway - multiple species 0 -0.445112782 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Lysosome 0 -0.494736842 -0.573070608 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Malaria -0.554945055 0 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Mineral absorption -0.604395604 0 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b mRNA surveillance pathway 0 0 0.441160372 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b MUFA%+blood 0 0 -0.553383459 serum_cytokines serum_fattyacid 0.632 0.00142 no no no up no dn MIP-1b Necroptosis -0.642857143 0 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Neuroactive ligand-receptor interaction 0 -0.457142857 -0.574165298 serum_cytokines kegg 0.632 NA no no no up up up MIP-1b Neutrophil extracellular trap formation 0 0 -0.568144499 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Non-small cell lung cancer 0 0.618045113 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Osteoclast differentiation 0 0 -0.427476738 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b p53 signaling pathway 0 0.630075188 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Pathogenic Escherichia coli infection 0 0 -0.541324576 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Pathways in cancer 0 0.494736842 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Pertussis 0 0 -0.457580733 serum_cytokines kegg 0.632 NA no no no no no dn MIP-1b Phagosome 0 0 -0.420908593 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Platinum drug resistance 0 0.533834586 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Progesterone-mediated oocyte maturation 0 0.47518797 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Ras signaling pathway 0 0 0.521072797 yes serum_cytokines kegg 0.632 NA no no no no up up MIP-1b Regulation of actin cytoskeleton 0 -0.6 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Renal cell carcinoma 0 0 0.45922277 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Ruminococcus 0.56043956 0 0 serum_cytokines Genus 0.632 0.0679 no no no no no dn MIP-1b Salmonella infection 0 0 -0.469074986 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Signaling pathways regulating pluripotency of stem cells 0 0.532330827 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Spinocerebellar ataxia 0 0.448120301 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Spliceosome 0 0.581954887 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Staphylococcus aureus infection 0 0 -0.625068418 serum_cytokines kegg 0.632 NA no no no up no no MIP-1b Systemic lupus erythematosus 0 0 -0.537493158 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b T cell receptor signaling pathway 0 0.485714286 0 serum_cytokines kegg 0.632 NA no no no no no no MIP-1b Taurine+blood 0 0 -0.476691729 serum_cytokines serum_aminoacids 0.632 0.857 no no no no no no MIP-1b TDCA+stool 0 -0.811516378 0 serum_cytokines stool_bileacids 0.632 0.963 no no no no no no MIP-1b TMAO+blood -0.648484848 0 -0.506766917 serum_cytokines serum_choline 0.632 0.00706 no no no up up no MIP-1b Tuberculosis 0 0 -0.63546798 serum_cytokines kegg 0.632 NA no no no no no dn MIP-1b Yersinia infection 0 0 -0.464148878 serum_cytokines kegg 0.632 NA no no no no no no Mismatch repair 2-Oxocarboxylic acid metabolism 0.525217391 0.564229249 0 kegg kegg NA NA no no no no no no Mismatch repair ABC transporters 0.495652174 0 0 kegg kegg NA NA no no no no up up Mismatch repair "Alanine, aspartate and glutamate metabolism" 0 -0.433794466 0 kegg kegg NA NA no no no no no no Mismatch repair Amino sugar and nucleotide sugar metabolism 0.602608696 0.423913043 0 kegg kegg NA NA no no no no no no Mismatch repair Aminoacyl-tRNA biosynthesis 0.653913043 0.67687747 0.501930502 kegg kegg NA NA no no no no no no Mismatch repair Antifolate resistance 0.480869565 0.520750988 0 kegg kegg NA NA no no no no no no Mismatch repair Arginine and proline metabolism 0 -0.508893281 0 kegg kegg NA NA no no no no up no Mismatch repair Arginine biosynthesis 0 -0.468379447 0 kegg kegg NA NA no no no no no no Mismatch repair Ascorbate and aldarate metabolism 0.573043478 0 0.420592021 kegg kegg NA NA no no no no no no Mismatch repair Basal transcription factors 0.419130435 0.639328063 0.6 kegg kegg NA NA no no no no no no Mismatch repair Base excision repair 0.58 0.681818182 0.748519949 kegg kegg NA NA no no no no no no Mismatch repair beta-Alanine metabolism 0.55826087 0.602766798 0.478507079 kegg kegg NA NA no no no no no no Mismatch repair Biosynthesis of cofactors 0 0.690711462 0 kegg kegg NA NA no no no no no no Mismatch repair Biosynthesis of unsaturated fatty acids 0.828695652 0.674901186 0.581467181 kegg kegg NA NA no no no no no no Mismatch repair Butanoate metabolism 0.674782609 0.804347826 0.699099099 kegg kegg NA NA no no no no no no Mismatch repair Citrate cycle (TCA cycle) 0.764347826 0.826086957 0.636293436 kegg kegg NA NA no no no no no no Mismatch repair Cysteine and methionine metabolism 0.783478261 0.83201581 0.732046332 kegg kegg NA NA no no no no no no Mismatch repair DNA replication 0.836521739 0.882411067 0.786872587 kegg kegg NA NA no no no no no no Mismatch repair Drug metabolism - cytochrome P450 0.467826087 0.782608696 0.42985843 kegg kegg NA NA no no no no no no Mismatch repair Drug metabolism - other enzymes 0.496521739 0.604743083 0 kegg kegg NA NA no no no no no no Mismatch repair EGFR tyrosine kinase inhibitor resistance 0 0.433794466 0.493436293 kegg kegg NA NA no no no no no no Mismatch repair Ether lipid metabolism 0 0.443675889 0.434491634 kegg kegg NA NA no no no no no no Mismatch repair Fatty acid biosynthesis 0 -0.460474308 0 kegg kegg NA NA no no no no no no Mismatch repair Fatty acid elongation 0.64 0.550395257 0.661003861 kegg kegg NA NA no no no no no no Mismatch repair Fatty acid metabolism 0.415652174 0 0 kegg kegg NA NA no no no no no no Mismatch repair Folate biosynthesis 0.412173913 0 0 kegg kegg NA NA no no no no no no Mismatch repair Glutathione metabolism 0 0.503952569 0 kegg kegg NA NA no no no no no no Mismatch repair "Glycine, serine and threonine metabolism" 0 0.444664032 0 kegg kegg NA NA no no no no up no Mismatch repair Glycolysis / Gluconeogenesis 0.594782609 0.577075099 0 kegg kegg NA NA no no no no no no Mismatch repair Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.512173913 -0.67687747 -0.436036036 kegg kegg NA NA no no no no no no Mismatch repair Glycosaminoglycan degradation -0.457391304 -0.43083004 0 kegg kegg NA NA no no no no no up Mismatch repair Glycosphingolipid biosynthesis - ganglio series 0 0.549407115 0 kegg kegg NA NA no no no no no no Mismatch repair Glycosphingolipid biosynthesis - lacto and neolacto series -0.47826087 -0.536561265 0 kegg kegg NA NA no no no no no no Mismatch repair Glyoxylate and dicarboxylate metabolism 0 -0.472332016 0 kegg kegg NA NA no no no no no no Mismatch repair Histidine metabolism 0.539130435 0 0 kegg kegg NA NA no no no no no no Mismatch repair Linoleic acid metabolism 0 0.454545455 0 kegg kegg NA NA no no no no no no Mismatch repair Mannose type O-glycan biosynthesis -0.422608696 0 0 kegg kegg NA NA no no no no no no Mismatch repair Metabolism of xenobiotics by cytochrome P450 0.464347826 0.748023715 0.442471042 kegg kegg NA NA no no no no no no Mismatch repair Mucin type O-glycan biosynthesis 0.672173913 0 0 kegg kegg NA NA no no no no no no Mismatch repair N-Glycan biosynthesis 0 0.605731225 0.400772201 kegg kegg NA NA no no no no no no Mismatch repair Nicotinate and nicotinamide metabolism 0 -0.549407115 0 kegg kegg NA NA no no no no no no Mismatch repair Nitrogen metabolism 0 -0.467391304 0 kegg kegg NA NA no no no no no no Mismatch repair Nucleotide excision repair 0.876521739 0.941699605 0.857400257 kegg kegg NA NA no no no no no no Mismatch repair One carbon pool by folate 0.789565217 0.831027668 0.543371943 kegg kegg NA NA no no no no no no Mismatch repair Pentose and glucuronate interconversions 0.792173913 0.741106719 0.529472329 kegg kegg NA NA no no no no no no Mismatch repair Pentose phosphate pathway 0 -0.511857708 0 kegg kegg NA NA no no no no no no Mismatch repair Phenylalanine metabolism 0.466956522 0.721343874 0 kegg kegg NA NA no no no no no no Mismatch repair PPAR signaling pathway 0 -0.612648221 -0.483912484 kegg kegg NA NA no no no no no no Mismatch repair Primary bile acid biosynthesis 0.92173913 0.666007905 0.405405405 kegg kegg NA NA no no no no no no Mismatch repair Propanoate metabolism 0.765217391 0.803359684 0.716859717 kegg kegg NA NA no no no no no no Mismatch repair Proteasome 0 0.551383399 0 kegg kegg NA NA no no no no no no Mismatch repair Protein export 0 0.493083004 0 kegg kegg NA NA no no no no no no Mismatch repair Pyrimidine metabolism 0.573043478 0.772727273 0 kegg kegg NA NA no no no no no no Mismatch repair Pyruvate metabolism 0.850434783 0.815217391 0.684942085 kegg kegg NA NA no no no no no no Mismatch repair Retinol metabolism 0.777391304 0.826086957 0.686743887 kegg kegg NA NA no no no no no no Mismatch repair Ribosome biogenesis in eukaryotes 0.473043478 0.738142292 0.558558559 kegg kegg NA NA no no no no no no Mismatch repair RNA degradation 0 0.483201581 0 kegg kegg NA NA no no no no no no Mismatch repair RNA polymerase 0 0.710474308 0.597168597 kegg kegg NA NA no no no no no no Mismatch repair RNA transport 0.537391304 0.421936759 0.402574003 kegg kegg NA NA no no no no no no Mismatch repair Selenocompound metabolism 0 0.453557312 0.511711712 kegg kegg NA NA no no no no no no Mismatch repair Sphingolipid metabolism -0.531304348 0 0 kegg kegg NA NA no no no no no no Mismatch repair Spliceosome 0.411304348 0 0 kegg kegg NA NA no no no no no no Mismatch repair Steroid biosynthesis 0 0.817193676 0.56036036 kegg kegg NA NA no no no no no no Mismatch repair Steroid hormone biosynthesis 0.67826087 0.761857708 0 kegg kegg NA NA no no no no no no Mismatch repair Sulfur metabolism 0 0.444664032 0 kegg kegg NA NA no no no no no no Mismatch repair Synthesis and degradation of ketone bodies 0.811304348 0.873517787 0.725611326 kegg kegg NA NA no no no no no no Mismatch repair Terpenoid backbone biosynthesis 0.55826087 0.649209486 0.473101673 kegg kegg NA NA no no no no no no Mismatch repair Thiamine metabolism 0.552173913 0.650197628 0 kegg kegg NA NA no no no no no no Mismatch repair Tryptophan metabolism 0.766086957 0.73715415 0.552380952 kegg kegg NA NA no no no no up no Mismatch repair Tyrosine metabolism 0.760869565 0.878458498 0.711711712 kegg kegg NA NA no no no no no no Mismatch repair Ubiquinone and other terpenoid-quinone biosynthesis 0.812173913 0.882411067 0.714285714 kegg kegg NA NA no no no no no no Mismatch repair "Valine, leucine and isoleucine degradation" 0.837391304 0.812252964 0.740540541 kegg kegg NA NA no no no no no no Mismatch repair Various types of N-glycan biosynthesis 0 0.505928854 0.403088803 kegg kegg NA NA no no no no no no Mitophagy - animal ABC transporters -0.486086957 0 0 kegg kegg NA NA no no no no up up Mitophagy - animal "Alanine, aspartate and glutamate metabolism" -0.453913043 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal alpha-Linolenic acid metabolism -0.445217391 -0.601778656 -0.474388674 kegg kegg NA NA no no no no no no Mitophagy - animal Amino sugar and nucleotide sugar metabolism -0.44173913 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Aminoacyl-tRNA biosynthesis -0.450434783 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Arachidonic acid metabolism 0 0 0.411840412 kegg kegg NA NA no no no no no no Mitophagy - animal Arginine and proline metabolism 0 -0.528656126 0 kegg kegg NA NA no no no no up no Mitophagy - animal Arginine biosynthesis -0.482608696 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Bacteroides -0.435652174 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Mitophagy - animal beta-Alanine metabolism -0.553913043 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Biosynthesis of amino acids -0.542608696 -0.532608696 0 kegg kegg NA NA no no no no no no Mitophagy - animal Biosynthesis of cofactors 0 0.483201581 0.561904762 kegg kegg NA NA no no no no no no Mitophagy - animal Biosynthesis of unsaturated fatty acids -0.623478261 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Calcium signaling pathway 0.533913043 0.668972332 0 kegg kegg NA NA no no no no up up Mitophagy - animal cAMP signaling pathway 0.565217391 0 0 yes kegg kegg NA NA no no no no up up Mitophagy - animal Carbon metabolism -0.477391304 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal cGMP-PKG signaling pathway 0 -0.54743083 -0.417503218 kegg kegg NA NA no no no no no no Mitophagy - animal Cytokine-cytokine receptor interaction 0 -0.451581028 0 kegg kegg NA NA no no no no no no Mitophagy - animal EGFR tyrosine kinase inhibitor resistance 0.462608696 0.571146245 0 kegg kegg NA NA no no no no no no Mitophagy - animal Endocrine resistance 0.448695652 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal ErbB signaling pathway 0 0 -0.557786358 kegg kegg NA NA no no no no no no Mitophagy - animal Ether lipid metabolism 0.593043478 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Fatty acid biosynthesis -0.537391304 -0.524703557 0 kegg kegg NA NA no no no no no no Mitophagy - animal Fatty acid degradation -0.764347826 -0.632411067 0 kegg kegg NA NA no no no no no no Mitophagy - animal Fatty acid elongation -0.58 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Fatty acid metabolism -0.805217391 -0.675889328 0 kegg kegg NA NA no no no no no no Mitophagy - animal FoxO signaling pathway -0.479130435 -0.597826087 0 kegg kegg NA NA no no no no no no Mitophagy - animal Galactose metabolism -0.603478261 -0.705533597 0 kegg kegg NA NA no no no no no no Mitophagy - animal Glutathione metabolism 0.46 0.666007905 0.6 kegg kegg NA NA no no no no no no Mitophagy - animal Glycerolipid metabolism 0 -0.504940711 -0.457915058 kegg kegg NA NA no no no no no up Mitophagy - animal "Glycine, serine and threonine metabolism" 0 0.600790514 0.563963964 kegg kegg NA NA no no no no up no Mitophagy - animal Glycolysis / Gluconeogenesis -0.445217391 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.493083004 -0.446074646 kegg kegg NA NA no no no no no no Mitophagy - animal Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.455855856 kegg kegg NA NA no no no no no no Mitophagy - animal Glycosaminoglycan biosynthesis - keratan sulfate 0.473913043 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Glycosaminoglycan degradation 0 -0.56027668 -0.589189189 kegg kegg NA NA no no no no no up Mitophagy - animal Glyoxylate and dicarboxylate metabolism -0.562608696 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal HIF-1 signaling pathway 0 0.497035573 0 kegg kegg NA NA no no no no no no Mitophagy - animal Histidine metabolism -0.473913043 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Inositol phosphate metabolism -0.464347826 0 -0.465122265 kegg kegg NA NA no no no no no no Mitophagy - animal Mannose type O-glycan biosynthesis 0.425217391 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal MAPK signaling pathway -0.450434783 -0.523715415 -0.471814672 kegg kegg NA NA no no no no no no Mitophagy - animal Mismatch repair -0.437391304 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal mRNA surveillance pathway 0.5 0.493083004 0 kegg kegg NA NA no no no no no no Mitophagy - animal Neuroactive ligand-receptor interaction -0.494782609 -0.611660079 0 kegg kegg NA NA no no no up up up Mitophagy - animal NF-kappa B signaling pathway -0.489565217 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Nicotinate and nicotinamide metabolism -0.507826087 -0.53458498 0 kegg kegg NA NA no no no no no no Mitophagy - animal Non-homologous end-joining -0.582608696 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Other glycan degradation 0 -0.472332016 -0.601287001 kegg kegg NA NA no no no no no no Mitophagy - animal Oxidative phosphorylation 0.490434783 0.798418972 0 kegg kegg NA NA no no no no no no Mitophagy - animal Pantothenate and CoA biosynthesis -0.66173913 -0.653162055 0 kegg kegg NA NA no no no no no dn Mitophagy - animal Pentose phosphate pathway 0 -0.587944664 0 kegg kegg NA NA no no no no no no Mitophagy - animal Porphyrin and chlorophyll metabolism 0 0.658102767 0.647876448 kegg kegg NA NA no no no no no no Mitophagy - animal Primary bile acid biosynthesis -0.490434783 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Protein export 0 0.477272727 0 kegg kegg NA NA no no no no no no Mitophagy - animal Purine metabolism 0.444347826 0.641304348 0.807722008 kegg kegg NA NA no no no no no no Mitophagy - animal Pyrimidine metabolism -0.499130435 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Pyruvate metabolism 0 0 0.404633205 kegg kegg NA NA no no no no no no Mitophagy - animal Retinol metabolism -0.566086957 0 0 kegg kegg NA NA no no no no no no Mitophagy - animal Ribosome 0.770434783 0.754940711 0.537194337 kegg kegg NA NA no no no no no no Mitophagy - animal RNA degradation 0.48173913 0.415019763 0 kegg kegg NA NA no no no no no no Mitophagy - animal RNA polymerase 0 0.43972332 0 kegg kegg NA NA no no no no no no Mitophagy - animal RNA transport 0 0.462450593 0 kegg kegg NA NA no no no no no no Mitophagy - animal SNARE interactions in vesicular transport 0 -0.583992095 0 kegg kegg NA NA no no no no no no Mitophagy - animal Sphingolipid metabolism 0 0 -0.527670528 kegg kegg NA NA no no no no no no Mitophagy - animal Sphingolipid signaling pathway 0 0 -0.68957529 kegg kegg NA NA no no no no no no Mitophagy - animal Starch and sucrose metabolism -0.52 -0.638339921 0 kegg kegg NA NA no no no no no no Mitophagy - animal Sulfur metabolism 0 0 0.526898327 kegg kegg NA NA no no no no no no Mitophagy - animal Tryptophan metabolism -0.477391304 0 0 kegg kegg NA NA no no no no up no Mitophagy - animal Ubiquitin mediated proteolysis 0.967826087 0.975296443 0.993307593 kegg kegg NA NA no no no no no no Mitophagy - animal Various types of N-glycan biosynthesis 0 0 -0.418532819 kegg kegg NA NA no no no no no no Morphine addiction 2-Oxocarboxylic acid metabolism -0.413913043 0 -0.552380952 kegg kegg NA NA no up up no no no Morphine addiction ABC transporters -0.669565217 0 0 kegg kegg NA NA no up up no up up Morphine addiction Adherens junction 0 0.447628458 0 kegg kegg NA NA no up up no no no Morphine addiction Adrenergic signaling in cardiomyocytes 0.74 0.654150198 0.63989704 kegg kegg NA NA no up up no no up Morphine addiction "Alanine, aspartate and glutamate metabolism" -0.467826087 -0.485177866 0 kegg kegg NA NA no up up no no no Morphine addiction Aldosterone synthesis and secretion 0.859130435 0.781620553 0.776833977 kegg kegg NA NA no up up no up up Morphine addiction alpha-Linolenic acid metabolism -0.64 0 -0.618018018 kegg kegg NA NA no up up no no no Morphine addiction Alzheimer disease 0.496521739 0.59486166 0 kegg kegg NA NA no up up no no no Morphine addiction Amino sugar and nucleotide sugar metabolism -0.477391304 0 -0.487773488 kegg kegg NA NA no up up no no no Morphine addiction Aminoacyl-tRNA biosynthesis -0.595652174 0 0 kegg kegg NA NA no up up no no no Morphine addiction Amphetamine addiction 0.640869565 0.638339921 0.757528958 kegg kegg NA NA no up up no no no Morphine addiction Amyotrophic lateral sclerosis 0.549565217 0.581027668 0 kegg kegg NA NA no up up no no no Morphine addiction Apoptosis 0 -0.41798419 0 kegg kegg NA NA no up up no no no Morphine addiction Arachidonic acid metabolism 0 0.528656126 0 kegg kegg NA NA no up up no no no Morphine addiction Arginine and proline metabolism -0.506956522 -0.416996047 0 kegg kegg NA NA no up up no up no Morphine addiction Arginine biosynthesis -0.439130435 -0.445652174 0 kegg kegg NA NA no up up no no no Morphine addiction Ascorbate and aldarate metabolism 0 0 -0.62007722 kegg kegg NA NA no up up no no no Morphine addiction Autophagy - animal 0 -0.459486166 -0.487516088 kegg kegg NA NA no up up no no no Morphine addiction B cell receptor signaling pathway 0 -0.416996047 0 kegg kegg NA NA no up up no no no Morphine addiction Base excision repair -0.434782609 0 0 kegg kegg NA NA no up up no no no Morphine addiction beta-Alanine metabolism -0.499130435 0 -0.520978121 kegg kegg NA NA no up up no no no Morphine addiction Bile secretion 0.893043478 0.890316206 0.808751609 kegg kegg NA NA no up up no no no Morphine addiction Biosynthesis of amino acids -0.409565217 -0.603754941 0 kegg kegg NA NA no up up no no no Morphine addiction Biosynthesis of unsaturated fatty acids -0.466956522 0 0 kegg kegg NA NA no up up no no no Morphine addiction Butanoate metabolism -0.440869565 0 0 kegg kegg NA NA no up up no no no Morphine addiction Butyricimonas 0.42062225 0 0 butyrate-producing kegg Genus NA 0.17 no up up no no no Morphine addiction C-type lectin receptor signaling pathway 0 -0.518774704 0 kegg kegg NA NA no up up no no no Morphine addiction Calcium signaling pathway 0.7 0.774703557 0.613384813 kegg kegg NA NA no up up no up up Morphine addiction cAMP signaling pathway 0.536521739 0 0.650707851 yes kegg kegg NA NA no up up no up up Morphine addiction Carbohydrate digestion and absorption 0 0 -0.487773488 kegg kegg NA NA no up up no no no Morphine addiction Carbon metabolism 0 -0.431818182 -0.472329472 kegg kegg NA NA no up up no no no Morphine addiction Cardiac muscle contraction 0.566086957 0.608695652 0 kegg kegg NA NA no up up no no up Morphine addiction Cell adhesion molecules 0 -0.563241107 0 kegg kegg NA NA no up up no no no Morphine addiction Cellular senescence 0 -0.416996047 0 kegg kegg NA NA no up up no no no Morphine addiction cGMP-PKG signaling pathway 0 -0.475296443 0 kegg kegg NA NA no up up no no no Morphine addiction Cholesterol metabolism 0 -0.476284585 0 yes kegg kegg NA NA no up up no no up Morphine addiction Circadian entrainment 0.657391304 0.735177866 0.845302445 kegg kegg NA NA no up up no up up Morphine addiction Citrate cycle (TCA cycle) -0.428695652 0 -0.569369369 kegg kegg NA NA no up up no no no Morphine addiction Cocaine addiction 0.772173913 0.813241107 0.873616474 kegg kegg NA NA no up up no no no Morphine addiction Coprococcus 0 0 -0.465538324 butyrate-producing kegg Genus NA 0.612 no up up no no no Morphine addiction Cortisol synthesis and secretion 0.739130435 0.778656126 0.891891892 kegg kegg NA NA no up up no no up Morphine addiction Cushing syndrome 0.793043478 0.710474308 0.680566281 kegg kegg NA NA no up up no no up Morphine addiction DNA replication -0.445217391 0 0 kegg kegg NA NA no up up no no no Morphine addiction Dopaminergic synapse 0.67826087 0.825098814 0.734620335 kegg kegg NA NA no up up no up no Morphine addiction Drug metabolism - other enzymes 0 0 -0.484427284 kegg kegg NA NA no up up no no no Morphine addiction Endocrine and other factor-regulated calcium reabsorption 0.873043478 0.882411067 0.844787645 kegg kegg NA NA no up up no no no Morphine addiction Endocrine resistance 0.614782609 0.738142292 0.682625483 kegg kegg NA NA no up up no no no Morphine addiction Endocytosis 0 -0.536561265 0 kegg kegg NA NA no up up no no no Morphine addiction Fanconi anemia pathway -0.440869565 0 0 kegg kegg NA NA no up up no no no Morphine addiction Fat digestion and absorption 0 0 -0.46975547 yes kegg kegg NA NA no up up no up up Morphine addiction Fatty acid biosynthesis -0.412173913 -0.472332016 0 kegg kegg NA NA no up up no no no Morphine addiction Fatty acid degradation -0.664347826 -0.646245059 -0.677220077 kegg kegg NA NA no up up no no no Morphine addiction Fatty acid metabolism -0.689565217 -0.616600791 -0.566280566 kegg kegg NA NA no up up no no no Morphine addiction Fc epsilon RI signaling pathway 0 -0.45256917 0 kegg kegg NA NA no up up no no no Morphine addiction Fc gamma R-mediated phagocytosis -0.428695652 -0.633399209 0 kegg kegg NA NA no up up no no no Morphine addiction Ferroptosis 0.50173913 0 0 kegg kegg NA NA no up up no no no Morphine addiction Fructose and mannose metabolism -0.479130435 0 -0.544401544 kegg kegg NA NA no up up no no no Morphine addiction Galactose metabolism -0.55826087 -0.424901186 -0.678507079 kegg kegg NA NA no up up no no no Morphine addiction Gap junction 0.719130435 0.696640316 0.745688546 kegg kegg NA NA no up up no no no Morphine addiction Gastric acid secretion 0.506956522 0.614624506 0 kegg kegg NA NA no up up no no no Morphine addiction Glucagon signaling pathway 0.622608696 0.677865613 0.487258687 kegg kegg NA NA no up up no no no Morphine addiction Glutamatergic synapse 0.712173913 0 0.703474903 kegg kegg NA NA no up up no up up Morphine addiction Glutathione metabolism 0 0.628458498 0 kegg kegg NA NA no up up no no no Morphine addiction Glycerolipid metabolism -0.471304348 0 -0.444015444 kegg kegg NA NA no up up no no up Morphine addiction Glycolysis / Gluconeogenesis 0 0 -0.472844273 kegg kegg NA NA no up up no no no Morphine addiction Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.474903475 kegg kegg NA NA no up up no no no Morphine addiction Glycosaminoglycan biosynthesis - keratan sulfate 0.551304348 0 0 kegg kegg NA NA no up up no no no Morphine addiction Glycosaminoglycan degradation 0 -0.481225296 -0.647361647 kegg kegg NA NA no up up no no up Morphine addiction Glyoxylate and dicarboxylate metabolism -0.629565217 -0.492094862 0 kegg kegg NA NA no up up no no no Morphine addiction GnRH signaling pathway 0.764347826 0.736166008 0.802574003 kegg kegg NA NA no up up no no no Morphine addiction "Growth hormone synthesis, secretion and action" 0 0 0.547490347 kegg kegg NA NA no up up no no no Morphine addiction Hippo signaling pathway - multiple species -0.451304348 0 -0.44993565 kegg kegg NA NA no up up no no no Morphine addiction Histidine metabolism -0.562608696 0 -0.639382239 kegg kegg NA NA no up up no no no Morphine addiction Homologous recombination -0.459130435 0 0 kegg kegg NA NA no up up no no no Morphine addiction Huntington disease 0.495652174 0.613636364 0 kegg kegg NA NA no up up no no no Morphine addiction IL-17 signaling pathway 0 -0.477272727 0 kegg kegg NA NA no up up no no no Morphine addiction Inflammatory mediator regulation of TRP channels 0.72 0.706521739 0.691891892 kegg kegg NA NA no up up no no no Morphine addiction Inositol phosphate metabolism -0.429565217 0 -0.433976834 kegg kegg NA NA no up up no no no Morphine addiction Insulin secretion 0.707826087 0.783596838 0.853796654 yes kegg kegg NA NA no up up no up up Morphine addiction Linoleic acid metabolism 0 0.502964427 0 kegg kegg NA NA no up up no no no Morphine addiction Long-term depression 0.899130435 0.645256917 0.881853282 kegg kegg NA NA no up up no no no Morphine addiction Longevity regulating pathway 0.415652174 0 0 kegg kegg NA NA no up up no no no Morphine addiction Longevity regulating pathway - multiple species 0 -0.589920949 0 kegg kegg NA NA no up up no no no Morphine addiction Lysosome 0 -0.479249012 0 kegg kegg NA NA no up up no no no Morphine addiction MAPK signaling pathway 0 -0.47826087 -0.495752896 kegg kegg NA NA no up up no no no Morphine addiction Maturity onset diabetes of the young 0 0.437747036 0 kegg kegg NA NA no up up no up no Morphine addiction Melanogenesis 0.775652174 0.731225296 0.776061776 kegg kegg NA NA no up up no no no Morphine addiction Mineral absorption 0.671304348 0.621541502 0.479279279 kegg kegg NA NA no up up no no no Morphine addiction Mismatch repair -0.492173913 0 0 kegg kegg NA NA no up up no no no Morphine addiction Mitophagy - animal 0.575652174 0.532608696 0 kegg kegg NA NA no up up no no no Morphine addiction Mucin type O-glycan biosynthesis 0 -0.473320158 0 kegg kegg NA NA no up up no no no Morphine addiction Natural killer cell mediated cytotoxicity 0 -0.467391304 0 kegg kegg NA NA no up up no no no Morphine addiction Necroptosis 0.533043478 0.427865613 0 kegg kegg NA NA no up up no no no Morphine addiction Neuroactive ligand-receptor interaction 0 -0.584980237 0 kegg kegg NA NA no up up up up up Morphine addiction Neutrophil extracellular trap formation 0 -0.416007905 0 kegg kegg NA NA no up up no no no Morphine addiction NF-kappa B signaling pathway -0.571304348 0 0 kegg kegg NA NA no up up no no no Morphine addiction Nicotinate and nicotinamide metabolism -0.47826087 0 0 kegg kegg NA NA no up up no no no Morphine addiction NOD-like receptor signaling pathway -0.557391304 -0.682806324 0 kegg kegg NA NA no up up no no no Morphine addiction Non-alcoholic fatty liver disease 0.562608696 0.580039526 0.484169884 kegg kegg NA NA no up up no no no Morphine addiction Non-homologous end-joining -0.414782609 0 0 kegg kegg NA NA no up up no no no Morphine addiction Nucleotide excision repair -0.43826087 0 0 kegg kegg NA NA no up up no no no Morphine addiction Odoribacter -0.426114464 -0.496782108 0 butyrate-producing kegg Genus NA 0.798 no up up no no no Morphine addiction Olfactory transduction 0 -0.434782609 0 kegg kegg NA NA no up up no no no Morphine addiction Oscillospira 0 -0.4743083 0 LPS-producing kegg Genus NA 0.62 no up up no no no Morphine addiction Osteoclast differentiation -0.457391304 -0.640316206 0 kegg kegg NA NA no up up no no no Morphine addiction Other glycan degradation -0.590434783 0 -0.498326898 kegg kegg NA NA no up up no no no Morphine addiction Ovarian steroidogenesis 0.673913043 0.821146245 0.85045045 kegg kegg NA NA no up up no up up Morphine addiction Oxidative phosphorylation 0.5 0.586956522 0 kegg kegg NA NA no up up no no no Morphine addiction Pancreatic secretion 0.906956522 0.888339921 0.934620335 kegg kegg NA NA no up up no no no Morphine addiction Pantothenate and CoA biosynthesis 0 -0.515810277 -0.507078507 kegg kegg NA NA no up up no no dn Morphine addiction "Parathyroid hormone synthesis, secretion and action" 0.609565217 0.632411067 0.623680824 kegg kegg NA NA no up up no no no Morphine addiction Parkinson disease 0.664347826 0.58201581 0.534620335 kegg kegg NA NA no up up no no no Morphine addiction Pathways of neurodegeneration - multiple diseases 0.660869565 0.566205534 0.497039897 kegg kegg NA NA no up up no no no Morphine addiction Pentose phosphate pathway 0 -0.468379447 0 kegg kegg NA NA no up up no no no Morphine addiction Peroxisome -0.664347826 -0.666996047 0 kegg kegg NA NA no up up no no no Morphine addiction Phagosome 0 -0.47826087 0 kegg kegg NA NA no up up no no no Morphine addiction Platelet activation 0 0.507905138 0 kegg kegg NA NA no up up no no no Morphine addiction PPAR signaling pathway -0.408695652 -0.675889328 0 kegg kegg NA NA no up up no no no Morphine addiction Prevotella -0.415215659 0 0 kegg Genus NA 0.367 no up up no no no Morphine addiction Prevotella 0 0 0.446718193 acetate-producing kegg Genus NA 0.287 no up up no no no Morphine addiction Primary bile acid biosynthesis -0.51826087 0 0 kegg kegg NA NA no up up no no no Morphine addiction Prion disease 0.496521739 0.499011858 0 kegg kegg NA NA no up up no no no Morphine addiction Propanoate metabolism -0.406086957 0 0 kegg kegg NA NA no up up no no no Morphine addiction Proteasome 0 0 -0.474131274 kegg kegg NA NA no up up no no no Morphine addiction Protein digestion and absorption -0.634782609 -0.742094862 -0.504247104 yes kegg kegg NA NA no up up no up up Morphine addiction Pyrimidine metabolism -0.513913043 0 0 kegg kegg NA NA no up up no no no Morphine addiction Pyruvate metabolism -0.452173913 0 0 kegg kegg NA NA no up up no no no Morphine addiction Rap1 signaling pathway 0 0.43972332 0 kegg kegg NA NA no up up no no no Morphine addiction Regulation of lipolysis in adipocytes 0.793043478 0.899209486 0.862033462 kegg kegg NA NA no up up no no no Morphine addiction Relaxin signaling pathway 0.48173913 0 0.661518662 kegg kegg NA NA no up up no no no Morphine addiction Renin secretion 0.688695652 0.679841897 0.759073359 kegg kegg NA NA no up up no no no Morphine addiction Renin-angiotensin system 0 -0.566205534 0 kegg kegg NA NA no up up no no no Morphine addiction Retinol metabolism -0.5 0 -0.507593308 kegg kegg NA NA no up up no no no Morphine addiction Retrograde endocannabinoid signaling 0 0.634387352 0 kegg kegg NA NA no up up no no up Morphine addiction Ribosome 0 0.470355731 0 kegg kegg NA NA no up up no no no Morphine addiction RIG-I-like receptor signaling pathway 0 -0.454545455 0 kegg kegg NA NA no up up no no no Morphine addiction Salivary secretion 0.670434783 0.585968379 0.619305019 kegg kegg NA NA no up up no no no Morphine addiction Selenocompound metabolism 0 0 -0.446589447 kegg kegg NA NA no up up no no no Morphine addiction Serotonergic synapse 0.487826087 0.583992095 0.657400257 kegg kegg NA NA no up up no no no Morphine addiction SNARE interactions in vesicular transport -0.631304348 -0.461462451 0 kegg kegg NA NA no up up no no no Morphine addiction Sphingolipid metabolism 0 0 -0.494980695 kegg kegg NA NA no up up no no no Morphine addiction Sphingolipid signaling pathway 0 -0.47826087 0 kegg kegg NA NA no up up no no no Morphine addiction Spinocerebellar ataxia 0 0 -0.435778636 kegg kegg NA NA no up up no no no Morphine addiction Starch and sucrose metabolism -0.433913043 -0.499011858 -0.579150579 kegg kegg NA NA no up up no no no Morphine addiction Steroid hormone biosynthesis 0 0 -0.556499356 kegg kegg NA NA no up up no no no Morphine addiction Synaptic vesicle cycle 0 -0.457509881 -0.426512227 kegg kegg NA NA no up up no up up Morphine addiction T cell receptor signaling pathway 0 -0.572134387 0 kegg kegg NA NA no up up no no no Morphine addiction Th1 and Th2 cell differentiation 0 -0.524703557 0 kegg kegg NA NA no up up no no no Morphine addiction Th17 cell differentiation 0 -0.625494071 0 kegg kegg NA NA no up up no no no Morphine addiction Thermogenesis 0.562608696 0.574110672 0 kegg kegg NA NA no up up no no no Morphine addiction Thyroid hormone signaling pathway 0 0.595849802 0 kegg kegg NA NA no up up no no no Morphine addiction Thyroid hormone synthesis 0.625217391 0.885375494 0.69009009 kegg kegg NA NA no up up no no no Morphine addiction Toll-like receptor signaling pathway 0 -0.462450593 0 yes kegg kegg NA NA no up up no no no Morphine addiction Tryptophan metabolism -0.524347826 0 -0.595624196 kegg kegg NA NA no up up no up no Morphine addiction Type I diabetes mellitus 0 -0.438735178 0 kegg kegg NA NA no up up no no no Morphine addiction Type II diabetes mellitus 0 0 -0.453024453 kegg kegg NA NA no up up no no no Morphine addiction Ubiquinone and other terpenoid-quinone biosynthesis -0.472173913 0 0 kegg kegg NA NA no up up no no no Morphine addiction Ubiquitin mediated proteolysis 0.562608696 0.550395257 0 kegg kegg NA NA no up up no no no Morphine addiction "Valine, leucine and isoleucine degradation" -0.54173913 0 -0.431145431 kegg kegg NA NA no up up no no no Morphine addiction Vascular smooth muscle contraction 0.775652174 0.634387352 0.723037323 kegg kegg NA NA no up up no no no Morphine addiction Vasopressin-regulated water reabsorption 0.829565217 0.921936759 0.897812098 kegg kegg NA NA no up up no no no Morphine addiction Viral protein interaction with cytokine and cytokine receptor 0 0 0.426254826 kegg kegg NA NA no up up no no no Morphine addiction Wnt signaling pathway 0.524347826 0.448616601 0 kegg kegg NA NA no up up no no no mRNA surveillance pathway 2-Oxocarboxylic acid metabolism -0.530434783 0.554347826 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway "Alanine, aspartate and glutamate metabolism" 0 -0.721343874 -0.634749035 kegg kegg NA NA no no no no no no mRNA surveillance pathway alpha-Linolenic acid metabolism -0.686956522 -0.674901186 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Amino sugar and nucleotide sugar metabolism -0.622608696 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Antifolate resistance 0 0 0.451994852 kegg kegg NA NA no no no no no no mRNA surveillance pathway Arachidonic acid metabolism 0 0 -0.583783784 kegg kegg NA NA no no no no no no mRNA surveillance pathway Arginine and proline metabolism 0 -0.678853755 -0.484427284 kegg kegg NA NA no no no no up no mRNA surveillance pathway Arginine biosynthesis -0.410434783 -0.76284585 -0.732818533 kegg kegg NA NA no no no no no no mRNA surveillance pathway beta-Alanine metabolism -0.706956522 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Biosynthesis of amino acids -0.907826087 -0.852766798 -0.867438867 kegg kegg NA NA no no no no no no mRNA surveillance pathway Biosynthesis of cofactors 0 0.446640316 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Butanoate metabolism -0.486956522 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Carbon metabolism -0.802608696 -0.43083004 -0.682625483 kegg kegg NA NA no no no no no no mRNA surveillance pathway Cysteine and methionine metabolism 0 0 0.407464607 kegg kegg NA NA no no no no no no mRNA surveillance pathway Drug metabolism - cytochrome P450 0 0.473320158 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Drug metabolism - other enzymes -0.656521739 0.437747036 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway EGFR tyrosine kinase inhibitor resistance 0.514782609 0.567193676 0.44015444 kegg kegg NA NA no no no no no no mRNA surveillance pathway Endocrine resistance 0.457391304 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Ether lipid metabolism 0.755652174 0.621541502 0.533333333 kegg kegg NA NA no no no no no no mRNA surveillance pathway Fatty acid biosynthesis 0 -0.789525692 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Fatty acid degradation -0.577391304 -0.631422925 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Fatty acid elongation -0.532173913 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Fatty acid metabolism -0.672173913 -0.73715415 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Folate biosynthesis 0 0.696640316 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Fructose and mannose metabolism -0.705217391 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Galactose metabolism -0.686956522 -0.567193676 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Glutathione metabolism 0 0.489130435 -0.472329472 kegg kegg NA NA no no no no no no mRNA surveillance pathway Glycerolipid metabolism 0 0 0.588674389 kegg kegg NA NA no no no no no up mRNA surveillance pathway Glycerophospholipid metabolism 0.453043478 0 0.701930502 kegg kegg NA NA no no no no no up mRNA surveillance pathway Glycolysis / Gluconeogenesis -0.760869565 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.447826087 0.518774704 0.412870013 kegg kegg NA NA no no no no no no mRNA surveillance pathway Glycosaminoglycan biosynthesis - keratan sulfate 0.530434783 0.634387352 0.526640927 kegg kegg NA NA no no no no no no mRNA surveillance pathway Glycosaminoglycan degradation 0 -0.445652174 0 kegg kegg NA NA no no no no no up mRNA surveillance pathway Glycosphingolipid biosynthesis - ganglio series 0 0.455533597 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.613913043 0 0.508365508 kegg kegg NA NA no no no no no no mRNA surveillance pathway Glyoxylate and dicarboxylate metabolism -0.475652174 -0.772727273 -0.714543115 kegg kegg NA NA no no no no no no mRNA surveillance pathway Inositol phosphate metabolism 0 0 0.58996139 kegg kegg NA NA no no no no no no mRNA surveillance pathway Lysine degradation 0.506086957 0.62944664 0.861261261 kegg kegg NA NA no no no no no no mRNA surveillance pathway Mannose type O-glycan biosynthesis 0.699130435 0.640316206 0.827799228 kegg kegg NA NA no no no no no no mRNA surveillance pathway Metabolism of xenobiotics by cytochrome P450 -0.460869565 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway N-Glycan biosynthesis 0.42173913 0.790513834 0.656628057 kegg kegg NA NA no no no no no no mRNA surveillance pathway Nicotinate and nicotinamide metabolism 0 -0.782608696 -0.574774775 kegg kegg NA NA no no no no no no mRNA surveillance pathway Nitrogen metabolism -0.49826087 -0.706521739 -0.625740026 kegg kegg NA NA no no no no no no mRNA surveillance pathway One carbon pool by folate 0 0.5 0.575804376 kegg kegg NA NA no no no no no no mRNA surveillance pathway Other types of O-glycan biosynthesis 0.677391304 0.539525692 0.784298584 kegg kegg NA NA no no no no no no mRNA surveillance pathway Oxidative phosphorylation 0.68 0.625494071 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Pantothenate and CoA biosynthesis 0 -0.808300395 -0.519176319 kegg kegg NA NA no no no no no dn mRNA surveillance pathway Parabacteroides -0.48 0 0 kegg Genus NA 4.19E-05 no no no no up up mRNA surveillance pathway Pentose and glucuronate interconversions 0 0.638339921 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Pentose phosphate pathway -0.614782609 -0.861660079 -0.788416988 kegg kegg NA NA no no no no no no mRNA surveillance pathway Phenylalanine metabolism -0.52173913 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Platinum drug resistance 0 0 0.45045045 kegg kegg NA NA no no no no no no mRNA surveillance pathway Purine metabolism 0 0.460474308 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Pyrimidine metabolism -0.588695652 0.418972332 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Pyruvate metabolism 0 0.456521739 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Retinol metabolism -0.553043478 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Ribosome 0.762608696 0.566205534 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Ribosome biogenesis in eukaryotes 0.52173913 0.647233202 0.784041184 kegg kegg NA NA no no no no no no mRNA surveillance pathway RNA transport 0 0.516798419 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Selenocompound metabolism 0.50173913 0 0.520978121 kegg kegg NA NA no no no no no no mRNA surveillance pathway Starch and sucrose metabolism -0.577391304 -0.754940711 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Steroid biosynthesis 0.433043478 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Sulfur metabolism 0 0 -0.564478764 kegg kegg NA NA no no no no no no mRNA surveillance pathway Taurine and hypotaurine metabolism 0 0 0.510682111 kegg kegg NA NA no no no no no no mRNA surveillance pathway Terpenoid backbone biosynthesis 0.42173913 0 0.558301158 kegg kegg NA NA no no no no no no mRNA surveillance pathway Tryptophan metabolism -0.504347826 0 0 kegg kegg NA NA no no no no up no mRNA surveillance pathway Tyrosine metabolism -0.509565217 0 0 kegg kegg NA NA no no no no no no mRNA surveillance pathway Various types of N-glycan biosynthesis 0 0.717391304 0.55958816 kegg kegg NA NA no no no no no no mTOR signaling pathway ABC transporters 0 -0.458498024 0 kegg kegg NA NA no no no no up up mTOR signaling pathway "Alanine, aspartate and glutamate metabolism" 0 -0.577075099 0 kegg kegg NA NA no no no no no no mTOR signaling pathway alpha-Linolenic acid metabolism 0 -0.790513834 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Arginine and proline metabolism 0 -0.56916996 0 kegg kegg NA NA no no no no up no mTOR signaling pathway Arginine biosynthesis 0 -0.545454545 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Autophagy - animal 0 -0.504940711 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Autophagy - other 0.540869565 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Basal transcription factors 0.486086957 0 0.481338481 kegg kegg NA NA no no no no no no mTOR signaling pathway Base excision repair 0.473043478 0 0.453281853 kegg kegg NA NA no no no no no no mTOR signaling pathway Biosynthesis of amino acids 0 -0.435770751 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Biosynthesis of cofactors 0 0.440711462 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Butanoate metabolism 0 0.535573123 0.557528958 kegg kegg NA NA no no no no no no mTOR signaling pathway Calcium signaling pathway 0 0.41798419 0 kegg kegg NA NA no no no no up up mTOR signaling pathway Cell cycle 0.413043478 0.422924901 0 kegg kegg NA NA no no no no no no mTOR signaling pathway cGMP-PKG signaling pathway 0 -0.511857708 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Chemokine signaling pathway 0 -0.421936759 -0.509395109 kegg kegg NA NA no no no no no no mTOR signaling pathway Citrate cycle (TCA cycle) 0 0.513833992 0.466924067 kegg kegg NA NA no no no no no no mTOR signaling pathway Cysteine and methionine metabolism 0 0.741106719 0.594079794 kegg kegg NA NA no no no no no no mTOR signaling pathway DNA replication 0.423478261 0.48715415 0.515057915 kegg kegg NA NA no no no no no no mTOR signaling pathway Drug metabolism - cytochrome P450 0 0.533596838 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Drug metabolism - other enzymes 0 0.540513834 0 kegg kegg NA NA no no no no no no mTOR signaling pathway EGFR tyrosine kinase inhibitor resistance 0.966956522 0.98715415 0.966280566 kegg kegg NA NA no no no no no no mTOR signaling pathway Fatty acid biosynthesis 0 -0.615612648 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Fatty acid degradation 0 -0.479249012 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Fatty acid metabolism 0 -0.475296443 0 kegg kegg NA NA no no no no no no mTOR signaling pathway FoxO signaling pathway 0 -0.557312253 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Fructose and mannose metabolism 0 -0.571146245 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Galactose metabolism 0 -0.698616601 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Glutathione metabolism 0 0.675889328 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Glycerolipid metabolism 0 -0.593873518 0 kegg kegg NA NA no no no no no up mTOR signaling pathway Glycerophospholipid metabolism 0 -0.445652174 0 kegg kegg NA NA no no no no no up mTOR signaling pathway Glycolysis / Gluconeogenesis 0 0.631422925 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.666007905 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Glycosaminoglycan degradation 0 -0.596837945 0 kegg kegg NA NA no no no no no up mTOR signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0 -0.437747036 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Glyoxylate and dicarboxylate metabolism 0 -0.506916996 0 kegg kegg NA NA no no no no no no mTOR signaling pathway HIF-1 signaling pathway 0.919130435 0.944664032 0.941312741 kegg kegg NA NA no no no no no no mTOR signaling pathway Lysine degradation 0.709565217 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Lysosome -0.469565217 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Mannose type O-glycan biosynthesis 0.445217391 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Metabolism of xenobiotics by cytochrome P450 0 0.458498024 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Mismatch repair 0 0.425889328 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Mitophagy - animal 0.523478261 0.589920949 0 kegg kegg NA NA no no no no no no mTOR signaling pathway mRNA surveillance pathway 0.473043478 0.583003953 0 kegg kegg NA NA no no no no no no mTOR signaling pathway N-Glycan biosynthesis 0 0.570158103 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Neuroactive ligand-receptor interaction 0 -0.480237154 0 kegg kegg NA NA no no no up up up mTOR signaling pathway NF-kappa B signaling pathway 0 -0.624505929 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Nicotinate and nicotinamide metabolism 0 -0.672924901 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Nitrogen metabolism 0 -0.476284585 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Non-homologous end-joining 0 0.416007905 0.430888031 kegg kegg NA NA no no no no no no mTOR signaling pathway Nucleotide excision repair 0 0 0.472586873 kegg kegg NA NA no no no no no no mTOR signaling pathway Oocyte meiosis 0 0.604743083 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Other glycan degradation 0 -0.519762846 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Other types of O-glycan biosynthesis 0.472173913 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Oxidative phosphorylation 0 0.65513834 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Pantothenate and CoA biosynthesis -0.462608696 -0.700592885 0 kegg kegg NA NA no no no no no dn mTOR signaling pathway Parabacteroides 0 0 -0.469270868 kegg Genus NA 4.19E-05 no no no no up up mTOR signaling pathway Pentose and glucuronate interconversions 0 0.536561265 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Pentose phosphate pathway 0 -0.5 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Peroxisome 0 -0.568181818 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Phagosome -0.464347826 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Phospholipase D signaling pathway 0 -0.754940711 -0.537194337 kegg kegg NA NA no no no no up up mTOR signaling pathway Propanoate metabolism 0 0.757905138 0.689317889 kegg kegg NA NA no no no no no no mTOR signaling pathway Proteasome 0 0.515810277 0.492921493 kegg kegg NA NA no no no no no no mTOR signaling pathway Protein export 0.555652174 0.739130435 0.540540541 kegg kegg NA NA no no no no no no mTOR signaling pathway Protein processing in endoplasmic reticulum 0.493043478 0.639328063 0.640926641 kegg kegg NA NA no no no no no no mTOR signaling pathway Pyruvate metabolism 0 0.791501976 0.641956242 kegg kegg NA NA no no no no no no mTOR signaling pathway Rap1 signaling pathway -0.469565217 0 -0.476962677 kegg kegg NA NA no no no no no no mTOR signaling pathway Ras signaling pathway 0 0.43972332 0 yes kegg kegg NA NA no no no no up up mTOR signaling pathway Ribosome 0.709565217 0.888339921 0.784041184 kegg kegg NA NA no no no no no no mTOR signaling pathway Ribosome biogenesis in eukaryotes 0.603478261 0 0.43989704 kegg kegg NA NA no no no no no no mTOR signaling pathway RNA degradation 0.513913043 0.690711462 0.465637066 kegg kegg NA NA no no no no no no mTOR signaling pathway RNA polymerase 0.536521739 0.550395257 0.544144144 kegg kegg NA NA no no no no no no mTOR signaling pathway RNA transport 0.584347826 0.951581028 0.730759331 kegg kegg NA NA no no no no no no mTOR signaling pathway Selenocompound metabolism 0.460869565 0 0 kegg kegg NA NA no no no no no no mTOR signaling pathway SNARE interactions in vesicular transport 0 -0.602766798 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Spliceosome 0.594782609 0 0.444015444 kegg kegg NA NA no no no no no no mTOR signaling pathway Starch and sucrose metabolism 0 -0.741106719 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Taurine and hypotaurine metabolism 0 -0.425889328 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Thiamine metabolism 0 0.743083004 0 kegg kegg NA NA no no no no no no mTOR signaling pathway Tryptophan metabolism 0 0 0.508880309 kegg kegg NA NA no no no no up no mTOR signaling pathway Ubiquitin mediated proteolysis 0.566956522 0.599802372 0 kegg kegg NA NA no no no no no no mTOR signaling pathway "Valine, leucine and isoleucine degradation" 0 0 0.42985843 kegg kegg NA NA no no no no no no mTOR signaling pathway Various types of N-glycan biosynthesis 0.525217391 0.460474308 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Citrate cycle (TCA cycle) 0.449565217 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Cysteine and methionine metabolism 0.725217391 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Fatty acid degradation 0 0.432806324 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Fatty acid elongation 0.445217391 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Glycolysis / Gluconeogenesis 0.567826087 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Lysine degradation 0 0.535573123 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Other glycan degradation 0 0.453557312 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Oxidative phosphorylation 0 -0.440711462 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Pentose and glucuronate interconversions 0.613043478 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Primary bile acid biosynthesis 0.615652174 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Pyrimidine metabolism 0.479130435 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Selenocompound metabolism 0 0.623517787 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Steroid hormone biosynthesis 0.572173913 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Synthesis and degradation of ketone bodies 0.548695652 0 0.435778636 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Tryptophan metabolism 0.433913043 0 0 kegg kegg NA NA no no no no up no Mucin type O-glycan biosynthesis Tyrosine metabolism 0.48173913 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis 0.512173913 0 0 kegg kegg NA NA no no no no no no Mucin type O-glycan biosynthesis "Valine, leucine and isoleucine degradation" 0.502608696 0 0 kegg kegg NA NA no no no no no no MUFA%+blood 12-ketoDCA+blood -0.584006029 0 0 serum_fattyacid serum_bileacids 0.00142 0.517 up no dn no no no MUFA%+blood 12-ketoDCA+stool 0 -0.697040533 0 serum_fattyacid stool_bileacids 0.00142 0.505 up no dn no no no MUFA%+blood 13-HODE+blood 0.565413534 0 0 serum_fattyacid serum_ARA 0.00142 0.32 up no dn no no no MUFA%+blood 14:0-LPC+blood -0.508270677 0 -0.40034188 serum_fattyacid serum_phospholipids 0.00142 0.00689 up no dn up up no MUFA%+blood 14:0/16:0-PC+blood -0.454135338 0 0 serum_fattyacid serum_phospholipids 0.00142 0.0358 up no dn no up no MUFA%+blood 14:0/18:2-PC+blood 0 -0.482843137 -0.506324786 serum_fattyacid serum_phospholipids 0.00142 0.102 up no dn no up no MUFA%+blood 14:0/20:4-PC+blood 0 0 -0.58017094 serum_fattyacid serum_phospholipids 0.00142 0.486 up no dn no no no MUFA%+blood 14:1/18:2-PG+blood 0 0 -0.423589744 serum_fattyacid serum_phospholipids 0.00142 0.00259 up no dn no up up MUFA%+blood 16:0/16:0-PI+blood -0.577443609 0 -0.44 serum_fattyacid serum_phospholipids 0.00142 0.358 up no dn no no no MUFA%+blood 16:0/16:1-PI+blood -0.732330827 0 0 serum_fattyacid serum_phospholipids 0.00142 0.262 up no dn no no no MUFA%+blood 16:0/18:1-PC+blood 0.607518797 0 0.498119658 serum_fattyacid serum_phospholipids 0.00142 6.15E-07 up no dn up up up MUFA%+blood 16:0/18:1-PE+blood -0.454135338 0 0 serum_fattyacid serum_phospholipids 0.00142 0.000107 up no dn up up no MUFA%+blood 16:0/18:2-PC+blood 0.526315789 0.5 0.569230769 serum_fattyacid serum_phospholipids 0.00142 3.24E-06 up no dn no up up MUFA%+blood 16:0/18:2-PI+blood -0.592481203 0 -0.414017094 serum_fattyacid serum_phospholipids 0.00142 0.269 up no dn no no no MUFA%+blood 16:0/20:3-PC+blood 0.514285714 0 0 serum_fattyacid serum_phospholipids 0.00142 5.43E-06 up no dn no up up MUFA%+blood 16:0/20:4-PI+blood -0.711278195 0 -0.468034188 serum_fattyacid serum_phospholipids 0.00142 0.558 up no dn no no no MUFA%+blood 16:0/20:5-PC+blood 0 0 -0.410598291 serum_fattyacid serum_phospholipids 0.00142 0.628 up no dn no no no MUFA%+blood 16:0/22:6-PC+blood 0 0 0.42974359 serum_fattyacid serum_phospholipids 0.00142 4.53E-05 up no dn no up up MUFA%+blood 16:1-LPC+blood 0 0.531862745 0 serum_fattyacid serum_phospholipids 0.00142 0.0241 up no dn no up no MUFA%+blood 16:1/16:0-PC+blood 0.547368421 0.517156863 0.401025641 serum_fattyacid serum_phospholipids 0.00142 0.0215 up no dn no up up MUFA%+blood 16:1/16:1-PC+blood 0.518796992 0 0 serum_fattyacid serum_phospholipids 0.00142 0.0177 up no dn no no up MUFA%+blood 16:1/18:2-PG+blood 0.556390977 0 0 serum_fattyacid serum_phospholipids 0.00142 1.40E-08 up no dn no up up MUFA%+blood 16:1+blood 0.520300752 0 0 yes serum_fattyacid serum_fattyacid 0.00142 0.0186 up no dn no no dn MUFA%+blood 18:0-LPA+blood 0 0.664215686 0 serum_fattyacid serum_phospholipids 0.00142 0.0725 up no dn no dn no MUFA%+blood 18:0/16:0-PC+blood 0.613533835 0 0.482393162 serum_fattyacid serum_phospholipids 0.00142 9.64E-07 up no dn up up up MUFA%+blood 18:0/18:0-PE+blood -0.645112782 0 0 serum_fattyacid serum_phospholipids 0.00142 0.00896 up no dn up up no MUFA%+blood 18:0/18:1-PE+blood -0.664661654 0 0 serum_fattyacid serum_phospholipids 0.00142 0.00716 up no dn up up no MUFA%+blood 18:0/18:2-PC+blood 0.545864662 0 0 serum_fattyacid serum_phospholipids 0.00142 1.74E-06 up no dn no up up MUFA%+blood 18:1-LPC+blood 0.586466165 0 0 serum_fattyacid serum_phospholipids 0.00142 0.179 up no dn no no no MUFA%+blood 18:1/16:0-PC+blood 0.515789474 0.490196078 0.593846154 serum_fattyacid serum_phospholipids 0.00142 2.43E-05 up no dn no up up MUFA%+blood 18:1/16:0-PE+blood -0.592481203 0 0 serum_fattyacid serum_phospholipids 0.00142 0.000182 up no dn up up no MUFA%+blood 18:1/16:0-PI+blood -0.532330827 0 0 serum_fattyacid serum_phospholipids 0.00142 0.793 up no dn no no no MUFA%+blood 18:1/16:1-PE+blood -0.515789474 0 0 serum_fattyacid serum_phospholipids 0.00142 0.000184 up no dn up up no MUFA%+blood 18:1/18:0-PC+blood 0.49924812 0 0 serum_fattyacid serum_phospholipids 0.00142 1.83E-06 up no dn no up up MUFA%+blood 18:1/18:0-PS+blood 0.490225564 0 0 serum_fattyacid serum_phospholipids 0.00142 0.193 up no dn no no no MUFA%+blood 18:1/18:2-PG+blood 0.521804511 0 0 serum_fattyacid serum_phospholipids 0.00142 5.58E-07 up no dn no up up MUFA%+blood 18:1/20:4-PC+blood 0.472180451 0 0 serum_fattyacid serum_phospholipids 0.00142 0.582 up no dn no no no MUFA%+blood 18:1+blood 0.47518797 0.590686275 0.556239316 yes serum_fattyacid serum_fattyacid 0.00142 0.00202 up no dn up no dn MUFA%+blood 18:2/16:0-PC+blood 0.529323308 0 0 serum_fattyacid serum_phospholipids 0.00142 8.67E-05 up no dn no up up MUFA%+blood 18:3/16:0-PE+blood -0.535338346 0 -0.434529915 serum_fattyacid serum_phospholipids 0.00142 0.00149 up no dn up up no MUFA%+blood 18:3n3+blood 0.52481203 0 0 serum_fattyacid serum_fattyacid 0.00142 0.291 up no dn no no no MUFA%+blood 18:3n6+blood -0.521804511 0 0 serum_fattyacid serum_fattyacid 0.00142 0.0463 up no dn up no dn MUFA%+blood 20:0/20:4-PE+blood 0 -0.607843137 0 serum_fattyacid serum_phospholipids 0.00142 0.00128 up no dn up up no MUFA%+blood 20:0/20:5-PC+blood 0.527819549 0 0 serum_fattyacid serum_phospholipids 0.00142 0.882 up no dn no no no MUFA%+blood 20:1-LPA+blood 0 0.544117647 0 serum_fattyacid serum_phospholipids 0.00142 0.0187 up no dn dn dn no MUFA%+blood 20:2+blood 0 0 0.503589744 serum_fattyacid serum_fattyacid 0.00142 0.478 up no dn no no no MUFA%+blood 20:4/16:0-PE+blood 0 0 -0.459145299 serum_fattyacid serum_phospholipids 0.00142 0.00529 up no dn no up up MUFA%+blood 20:5/18:0-PC+blood 0 0 0.463931624 serum_fattyacid serum_phospholipids 0.00142 3.97E-06 up no dn no up up MUFA%+blood 22:1-LPA+blood 0 0.504901961 0 serum_fattyacid serum_phospholipids 0.00142 0.00373 up no dn no up up MUFA%+blood AA+blood 0.607518797 0 0 serum_fattyacid serum_ARA 0.00142 0.212 up no dn no no no MUFA%+blood ACA+stool 0.595146513 0 0 serum_fattyacid stool_bileacids 0.00142 0.417 up no dn no no no MUFA%+blood Adrenergic signaling in cardiomyocytes 0 -0.555882353 -0.456153846 serum_fattyacid kegg 0.00142 NA up no dn no no up MUFA%+blood Aldosterone synthesis and secretion 0 -0.538235294 -0.5 serum_fattyacid kegg 0.00142 NA up no dn no up up MUFA%+blood Amphetamine addiction 0 0 -0.443846154 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Antigen processing and presentation 0 0 0.433076923 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Apelin signaling pathway 0 -0.561764706 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Arginine and proline metabolism 0 0 0.404615385 serum_fattyacid kegg 0.00142 NA up no dn no up no MUFA%+blood B cell receptor signaling pathway 0.529824561 0 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Biosynthesis of amino acids 0 0.505882353 0.451538462 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Biosynthesis of cofactors -0.589473684 0 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Blautia 0 0.529411765 0 acetate-producing serum_fattyacid Genus 0.00142 1.36E-05 up no dn up dn dn MUFA%+blood Butyricimonas 0 -0.568887169 0 butyrate-producing serum_fattyacid Genus 0.00142 0.17 up no dn no no no MUFA%+blood CA+blood 0 -0.53832015 -0.569128563 serum_fattyacid serum_bileacids 0.00142 0.606 up no dn no no no MUFA%+blood Calcium signaling pathway 0 -0.517647059 -0.526923077 serum_fattyacid kegg 0.00142 NA up no dn no up up MUFA%+blood capric acid C6+blood 0 0 0.444786325 serum_fattyacid serum_scfa 0.00142 0.433 up no dn no no no MUFA%+blood Carbon metabolism 0 0 0.582307692 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood CDCA+blood 0 0 -0.541880342 serum_fattyacid serum_bileacids 0.00142 0.506 up no dn no no no MUFA%+blood cGMP-PKG signaling pathway 0 0 0.41 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Chemical carcinogenesis - receptor activation 0 -0.541176471 -0.493076923 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Chemokine signaling pathway 0.478947368 0 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Choline metabolism in cancer 0 0 -0.406923077 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Cocaine addiction 0 0 -0.500769231 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Colorectal cancer 0 -0.558823529 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Coprococcus -0.562406015 0 0 butyrate-producing serum_fattyacid Genus 0.00142 0.612 up no dn no no no MUFA%+blood Coronavirus disease - COVID-19 0 -0.570588235 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Cortisol synthesis and secretion 0 0 -0.629230769 serum_fattyacid kegg 0.00142 NA up no dn no no up MUFA%+blood Creatinine+blood 0.661654135 0.534313725 0.646495726 serum_fattyacid serum_choline 0.00142 0.437 up no dn no no no MUFA%+blood Cushing syndrome 0 -0.564705882 -0.657692308 serum_fattyacid kegg 0.00142 NA up no dn no no up MUFA%+blood Cysteine+blood 0 0.49754902 0.673846154 yes serum_fattyacid serum_aminoacids 0.00142 1.81E-07 up no dn dn up up MUFA%+blood Cystine+blood 0.445112782 0.691176471 0.552820513 yes serum_fattyacid serum_aminoacids 0.00142 0.00028 up no dn up up no MUFA%+blood d18:1-14:0-SM+blood 0 -0.531862745 -0.486495726 serum_fattyacid serum_phospholipids 0.00142 0.94 up no dn no no no MUFA%+blood d18:1-14:1-SM+blood 0 -0.541666667 -0.483076923 serum_fattyacid serum_phospholipids 0.00142 0.0952 up no dn no dn no MUFA%+blood d18:1-16:1-SM+blood 0 -0.504901961 -0.419487179 serum_fattyacid serum_phospholipids 0.00142 0.2 up no dn no no no MUFA%+blood d18:1-18:0-SM+blood 0.583458647 0 0 serum_fattyacid serum_phospholipids 0.00142 0.97 up no dn no no no MUFA%+blood d18:1-18:1-SM+blood 0.497744361 0 0 serum_fattyacid serum_phospholipids 0.00142 0.916 up no dn no no no MUFA%+blood d18:1-20:1-SM+blood 0.512781955 0 0 serum_fattyacid serum_phospholipids 0.00142 0.0992 up no dn no no no MUFA%+blood DCA+blood 0 0 -0.45982906 serum_fattyacid serum_bileacids 0.00142 0.122 up no dn no no no MUFA%+blood Dopaminergic synapse 0 -0.526470588 0 serum_fattyacid kegg 0.00142 NA up no dn no up no MUFA%+blood EGFR tyrosine kinase inhibitor resistance 0 -0.617647059 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Endocrine and other factor-regulated calcium reabsorption 0 0 -0.467692308 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Endocrine resistance 0 -0.526470588 -0.625384615 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Endocytosis 0 0.55 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Epithelial cell signaling in Helicobacter pylori infection 0.505263158 0 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Fc epsilon RI signaling pathway 0.540350877 0 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Fc gamma R-mediated phagocytosis 0 0.585294118 0.623846154 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Fusobacterium 0 0 0.462650554 serum_fattyacid Genus 0.00142 0.628 up no dn no no no MUFA%+blood Gastric cancer 0 0 -0.456923077 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood GCDCA+blood -0.523308271 0 0 serum_fattyacid serum_bileacids 0.00142 0.31 up no dn no no no MUFA%+blood Glucagon signaling pathway 0 0 -0.495384615 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood "Glycine, serine and threonine metabolism" -0.561403509 0 0 serum_fattyacid kegg 0.00142 NA up no dn no up no MUFA%+blood Glycine+blood 0 0.536764706 0.459145299 serum_fattyacid serum_aminoacids 0.00142 0.00408 up no dn dn no up MUFA%+blood "Growth hormone synthesis, secretion and action" 0 0 -0.586153846 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood HCA+blood -0.520427215 -0.502312258 0 serum_fattyacid serum_bileacids 0.00142 0.544 up no dn no no no MUFA%+blood HIF-1 signaling pathway 0 -0.532352941 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood IL-17 signaling pathway 0 0 0.475384615 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Inflammatory mediator regulation of TRP channels 0 0 -0.522307692 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Influenza A 0.573684211 0 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Insulin secretion 0 0 -0.569230769 yes serum_fattyacid kegg 0.00142 NA up no dn no up up MUFA%+blood Insulin signaling pathway 0 -0.55 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood iso-DCA+blood 0.496240602 0 0 serum_fattyacid serum_bileacids 0.00142 0.38 up no dn no no no MUFA%+blood isobutyric acid C4+blood 0 0 0.406495726 serum_fattyacid serum_scfa 0.00142 0.0151 up no dn up up no MUFA%+blood L-Asparagine+blood 0 0.575980392 0.452991453 serum_fattyacid serum_aminoacids 0.00142 0.784 up no dn no no no MUFA%+blood L-Glutamine+blood 0 0 0.641709402 serum_fattyacid serum_aminoacids 0.00142 0.639 up no dn no no no MUFA%+blood L-Histidine+blood 0.47518797 0 0.457094017 serum_fattyacid serum_aminoacids 0.00142 0.109 up no dn no no no MUFA%+blood L-Isoleucine+blood 0 0.593137255 0 yes serum_fattyacid serum_aminoacids 0.00142 5.47E-06 up no dn up up no MUFA%+blood L-Leucine+blood 0 0.509803922 0 yes serum_fattyacid serum_aminoacids 0.00142 3.22E-05 up no dn up up no MUFA%+blood L-Lysine+blood 0.547368421 0.62745098 0 yes serum_fattyacid serum_aminoacids 0.00142 0.0107 up no dn no up no MUFA%+blood L-Methionine+blood 0 0.656862745 0 serum_fattyacid serum_aminoacids 0.00142 0.626 up no dn no no no MUFA%+blood L-Phenylalanine+blood 0 0.56127451 0 yes serum_fattyacid serum_aminoacids 0.00142 0.0103 up no dn up up no MUFA%+blood L-Threonine+blood 0 0.634803922 0 serum_fattyacid serum_aminoacids 0.00142 0.0538 up no dn dn no up MUFA%+blood L-Tryptophan+blood 0.44962406 0 0 serum_fattyacid serum_aminoacids 0.00142 0.164 up no dn no no no MUFA%+blood Lachnospira -0.473684211 0 0 butyrate-producing serum_fattyacid Genus 0.00142 0.279 up no dn no no no MUFA%+blood lauric acid C12+blood 0.518796992 0 0 serum_fattyacid serum_mcfa 0.00142 0.015 up no dn no dn dn MUFA%+blood Legionellosis -0.512280702 0 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Lipid and atherosclerosis 0.464912281 0.723529412 0.558461538 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Long-term depression 0 0 -0.47 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Lysosome 0 0 0.534615385 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Melanogenesis 0 0 -0.449230769 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Morphine addiction 0 -0.517647059 0 serum_fattyacid kegg 0.00142 NA up no dn no up up MUFA%+blood mRNA surveillance pathway 0 -0.526470588 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood mTOR signaling pathway 0 -0.605882353 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood MUFA+blood 0.521804511 0.553921569 0.569230769 serum_fattyacid serum_fattyacid 0.00142 0.00175 up no dn up no dn MUFA%+blood Neuroactive ligand-receptor interaction 0 0.588235294 0.503076923 serum_fattyacid kegg 0.00142 NA up no dn up up up MUFA%+blood Neutrophil extracellular trap formation 0 0.532352941 0.44 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood NOD-like receptor signaling pathway 0 0.570588235 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Non-alcoholic fatty liver disease 0 0 -0.423076923 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Olfactory transduction 0 0.505882353 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Pancreatic secretion 0 0 -0.477692308 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Pathways in cancer 0 0 -0.405384615 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Peroxisome 0 0.579411765 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Pertussis 0.498245614 0.647058824 0.420769231 serum_fattyacid kegg 0.00142 NA up no dn no no dn MUFA%+blood Phospholipase D signaling pathway 0 0 -0.42 serum_fattyacid kegg 0.00142 NA up no dn no up up MUFA%+blood PI3K-Akt signaling pathway -0.49122807 0 0 yes serum_fattyacid kegg 0.00142 NA up no dn no up up MUFA%+blood Platinum drug resistance 0 0 -0.421538462 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Porphyrin and chlorophyll metabolism -0.463157895 0 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Prevotella -0.536341014 0 0 acetate-producing serum_fattyacid Genus 0.00142 0.287 up no dn no no no MUFA%+blood Prion disease 0 -0.505882353 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Prolactin signaling pathway 0.473684211 0 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Propionic acid+stool 0 0 -0.563909774 yes serum_fattyacid stool_scfa 0.00142 0.0436 up no dn dn no up MUFA%+blood Proteasome 0 0 0.576923077 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Protein processing in endoplasmic reticulum 0 -0.526470588 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Proteoglycans in cancer 0 -0.594117647 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Regulation of lipolysis in adipocytes 0 0 -0.409230769 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Retrograde endocannabinoid signaling 0 -0.517647059 0 serum_fattyacid kegg 0.00142 NA up no dn no no up MUFA%+blood Ribosome 0 -0.570588235 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood RNA degradation 0 -0.532352941 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood RNA transport -0.50877193 -0.576470588 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Ruminococcus 0 0 -0.487807135 serum_fattyacid Genus 0.00142 0.0679 up no dn no no dn MUFA%+blood Signaling pathways regulating pluripotency of stem cells 0 0 -0.42 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Staphylococcus aureus infection 0 0.505882353 0.551538462 serum_fattyacid kegg 0.00142 NA up no dn up no no MUFA%+blood Systemic lupus erythematosus 0 0 0.487692308 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Thermogenesis 0 -0.535294118 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Thyroid hormone synthesis 0 -0.5 -0.432307692 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Tight junction 0 0 0.421538462 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Toll-like receptor signaling pathway 0.503508772 0 0 yes serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Tuberculosis 0 0.523529412 0.549230769 serum_fattyacid kegg 0.00142 NA up no dn no no dn MUFA%+blood Vasopressin-regulated water reabsorption 0 0 -0.414615385 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA%+blood Wnt signaling pathway 0 -0.541176471 0 serum_fattyacid kegg 0.00142 NA up no dn no no no MUFA+blood 12-ketoDCA+blood -0.480756345 -0.56642726 0 serum_fattyacid serum_bileacids 0.00175 0.517 up no dn no no no MUFA+blood "12,13-EPOME+blood" 0.468239384 0 0 serum_fattyacid serum_ARA 0.00175 0.901 up no dn no no no MUFA+blood 13-HODE+blood 0.520300752 0 0 serum_fattyacid serum_ARA 0.00175 0.32 up no dn no no no MUFA+blood 14:0+blood 0 0.512254902 0 yes serum_fattyacid serum_fattyacid 0.00175 0.00572 up no dn up no dn MUFA+blood 14:1/18:2-PG+blood -0.487218045 0 0 serum_fattyacid serum_phospholipids 0.00175 0.00259 up no dn no up up MUFA+blood 16:0/18:1-PC+blood 0 0 0.618461538 serum_fattyacid serum_phospholipids 0.00175 6.15E-07 up no dn up up up MUFA+blood 16:0/20:4-PE+blood 0 0 0.425641026 serum_fattyacid serum_phospholipids 0.00175 0.00139 up no dn up up no MUFA+blood 16:0/20:5-PG+blood 0 0 -0.416068376 serum_fattyacid serum_phospholipids 0.00175 0.00656 up no dn no up no MUFA+blood 16:0+blood 0.766917293 0.509803922 0.573333333 yes serum_fattyacid serum_fattyacid 0.00175 0.00876 up no dn up no no MUFA+blood 16:1+blood 0.833082707 0.629901961 0.646495726 yes serum_fattyacid serum_fattyacid 0.00175 0.0186 up no dn no no dn MUFA+blood 18:0/16:0-PC+blood 0 0 0.596581197 serum_fattyacid serum_phospholipids 0.00175 9.64E-07 up no dn up up up MUFA+blood 18:0/20:2-PC+blood 0 -0.544117647 0 serum_fattyacid serum_phospholipids 0.00175 0.733 up no dn no no no MUFA+blood 18:0/20:3-PI+blood 0.532330827 0 0 serum_fattyacid serum_phospholipids 0.00175 0.377 up no dn no no no MUFA+blood 18:0/20:4-PI+blood 0.533834586 0.536764706 0 serum_fattyacid serum_phospholipids 0.00175 0.167 up no dn no no no MUFA+blood 18:0+blood 0.640601504 0 0 serum_fattyacid serum_fattyacid 0.00175 0.344 up no dn no no no MUFA+blood 18:1/16:1-PE+blood 0 0 0.405128205 serum_fattyacid serum_phospholipids 0.00175 0.000184 up no dn up up no MUFA+blood 18:1/18:0-PS+blood 0 0.504901961 0 serum_fattyacid serum_phospholipids 0.00175 0.193 up no dn no no no MUFA+blood 18:1/18:1-PE+blood 0 0 0.454358974 serum_fattyacid serum_phospholipids 0.00175 1.03E-05 up no dn up up no MUFA+blood 18:1/18:2-PG+blood 0 0 -0.507692308 serum_fattyacid serum_phospholipids 0.00175 5.58E-07 up no dn no up up MUFA+blood 18:1/20:4-PE+blood 0 0.492647059 0 serum_fattyacid serum_phospholipids 0.00175 0.0578 up no dn up no no MUFA+blood 18:1/20:4-PI+blood 0 0.674019608 0 serum_fattyacid serum_phospholipids 0.00175 0.192 up no dn no no no MUFA+blood 18:1/22:6-PE+blood 0 0.625 0 serum_fattyacid serum_phospholipids 0.00175 0.0047 up no dn no up no MUFA+blood 18:1+blood 0.995488722 0.990196078 0.98974359 yes serum_fattyacid serum_fattyacid 0.00175 0.00202 up no dn up no dn MUFA+blood 18:2n6c+blood 0.544360902 0 0 serum_fattyacid serum_fattyacid 0.00175 0.15 up no dn no no no MUFA+blood 18:3-LPC+blood 0 0 -0.448888889 serum_fattyacid serum_phospholipids 0.00175 0.147 up no dn no no no MUFA+blood 18:3n3+blood 0.515789474 0 0 serum_fattyacid serum_fattyacid 0.00175 0.291 up no dn no no no MUFA+blood 20:1+blood 0 0.49754902 0 yes serum_fattyacid serum_fattyacid 0.00175 2.56E-05 up no dn dn dn dn MUFA+blood 20:2/18:3-PE+blood 0 0.634803922 0 serum_fattyacid serum_phospholipids 0.00175 0.0391 up no dn up up no MUFA+blood 20:3-LPE+blood 0.446616541 0 0 serum_fattyacid serum_phospholipids 0.00175 0.084 up no dn no up no MUFA+blood 20:3/18:0-PI+blood 0.484210526 0 0 serum_fattyacid serum_phospholipids 0.00175 0.289 up no dn no no no MUFA+blood 20:4-LPC+blood 0 0 -0.419487179 serum_fattyacid serum_phospholipids 0.00175 0.949 up no dn no no no MUFA+blood 20:4/18:0-PE+blood 0 0.492647059 0 serum_fattyacid serum_phospholipids 0.00175 0.000755 up no dn up up no MUFA+blood 24:1+blood 0 0.612745098 0 serum_fattyacid serum_fattyacid 0.00175 0.00582 up no dn no dn dn MUFA+blood AA+blood 0.454135338 0 0 serum_fattyacid serum_ARA 0.00175 0.212 up no dn no no no MUFA+blood AGE-RAGE signaling pathway in diabetic complications 0.615789474 0 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Alcoholism 0 0.564705882 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood AMPK signaling pathway -0.461403509 0 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Antigen processing and presentation 0 0 0.492307692 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Arginine and proline metabolism 0 0 0.49 serum_fattyacid kegg 0.00175 NA up no dn no up no MUFA+blood Bifidobacterium 0 -0.505211622 0 acetate-producing serum_fattyacid Genus 0.00175 0.105 up no dn no dn no MUFA+blood Biosynthesis of amino acids 0 0 0.421538462 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Biosynthesis of cofactors -0.68245614 0 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood CA+blood -0.445280212 0 0 serum_fattyacid serum_bileacids 0.00175 0.606 up no dn no no no MUFA+blood Calcium signaling pathway 0 -0.611764706 0 serum_fattyacid kegg 0.00175 NA up no dn no up up MUFA+blood Carbon metabolism 0 0 0.440769231 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood CDCA+blood 0 0 -0.45982906 serum_fattyacid serum_bileacids 0.00175 0.506 up no dn no no no MUFA+blood Cell adhesion molecules 0 0 0.416153846 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood cGMP-PKG signaling pathway 0.607017544 0 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Cholinergic synapse 0.538596491 0 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Cushing syndrome 0 0 -0.414615385 serum_fattyacid kegg 0.00175 NA up no dn no no up MUFA+blood Cysteine+blood 0 0 0.448888889 yes serum_fattyacid serum_aminoacids 0.00175 1.81E-07 up no dn dn up up MUFA+blood d18:0-24:1-SM+blood 0 -0.536764706 0 serum_fattyacid serum_phospholipids 0.00175 0.0609 up no dn no dn dn MUFA+blood d18:1-22:0-SM+blood 0 -0.566176471 0 serum_fattyacid serum_phospholipids 0.00175 0.522 up no dn no no no MUFA+blood Endocytosis 0 0 0.410769231 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Epithelial cell signaling in Helicobacter pylori infection 0 0 0.457692308 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Epstein-Barr virus infection 0 0 0.41 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Fc gamma R-mediated phagocytosis 0 0 0.526153846 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood FoxO signaling pathway 0 0.502941176 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood GABAergic synapse 0.561403509 0 0 serum_fattyacid kegg 0.00175 NA up no dn no up up MUFA+blood Gastric cancer 0 0 -0.417692308 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood GLCA+blood 0 -0.516353281 0 serum_fattyacid serum_bileacids 0.00175 0.319 up no dn no no no MUFA+blood Glioma 0.621052632 0.573529412 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood "Glycine, serine and threonine metabolism" -0.594736842 0 0 serum_fattyacid kegg 0.00175 NA up no dn no up no MUFA+blood HCA+blood -0.477756755 0 -0.47474693 serum_fattyacid serum_bileacids 0.00175 0.544 up no dn no no no MUFA+blood HCA+stool 0.604395604 0 0 serum_fattyacid stool_bileacids 0.00175 0.155 up no dn no no no MUFA+blood Human immunodeficiency virus 1 infection 0 0 0.441538462 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Human T-cell leukemia virus 1 infection 0 0 0.453076923 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood IL-17 signaling pathway 0 0 0.428461538 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Inflammatory bowel disease 0.510526316 0 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood L-Leucine+blood -0.521804511 0 0 yes serum_fattyacid serum_aminoacids 0.00175 3.22E-05 up no dn up up no MUFA+blood L-Proline+blood -0.560902256 0 -0.506324786 yes serum_fattyacid serum_aminoacids 0.00175 0.00265 up no dn up up no MUFA+blood Leishmaniasis 0 0 0.506153846 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Lipid and atherosclerosis 0.670175439 0 0.610769231 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Long-term potentiation 0.492982456 0 0 serum_fattyacid kegg 0.00175 NA up no dn no no up MUFA+blood Mineral absorption 0 -0.529411765 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Mitophagy - animal 0 -0.541176471 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Nicotinate and nicotinamide metabolism 0 0.520588235 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood NOD-like receptor signaling pathway 0.559649123 0 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Olfactory transduction 0.522807018 0 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Osteoclast differentiation 0 0 0.47 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Peroxisome 0.471929825 0 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Pertussis 0.598245614 0 0.493076923 serum_fattyacid kegg 0.00175 NA up no dn no no dn MUFA+blood Phagosome 0 0 0.487692308 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Porphyrin and chlorophyll metabolism -0.598245614 -0.505882353 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood PPAR signaling pathway 0 0 0.482307692 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Prolactin signaling pathway 0.489473684 0 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Proteoglycans in cancer -0.622807018 -0.576470588 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Ras signaling pathway 0 0 -0.401538462 yes serum_fattyacid kegg 0.00175 NA up no dn no up up MUFA+blood Salivary secretion 0 0.523529412 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Shigellosis -0.528070175 0 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Sphingolipid signaling pathway 0.585964912 0 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Staphylococcus aureus infection 0 0 0.603846154 serum_fattyacid kegg 0.00175 NA up no dn up no no MUFA+blood Systemic lupus erythematosus 0 0 0.581538462 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Toll-like receptor signaling pathway 0 0 0.427692308 yes serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Toxoplasmosis 0 0 0.496153846 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood Tuberculosis 0.477192982 0 0.473076923 serum_fattyacid kegg 0.00175 NA up no dn no no dn MUFA+blood Ubiquitin mediated proteolysis -0.468421053 -0.520588235 0 serum_fattyacid kegg 0.00175 NA up no dn no no no MUFA+blood VEGF signaling pathway 0.547368421 0 0 serum_fattyacid kegg 0.00175 NA up no dn no no no N-Glycan biosynthesis "Alanine, aspartate and glutamate metabolism" 0 -0.839920949 -0.486486486 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Arginine and proline metabolism -0.615652174 -0.802371542 -0.552638353 kegg kegg NA NA no no no no up no N-Glycan biosynthesis Arginine biosynthesis -0.423478261 -0.862648221 -0.606949807 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Ascorbate and aldarate metabolism 0 0.541501976 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Citrate cycle (TCA cycle) 0 0.747035573 0.543629344 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Cysteine and methionine metabolism 0.413043478 0.68972332 0.565765766 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Fatty acid biosynthesis 0 -0.831027668 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Fatty acid degradation 0 -0.517786561 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Galactose metabolism 0 -0.461462451 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Glutathione metabolism 0 0.527667984 -0.406435006 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Glycolysis / Gluconeogenesis 0 0.446640316 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Lysine degradation 0.475652174 0.479249012 0.641956242 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Oxidative phosphorylation 0 0.551383399 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Pentose and glucuronate interconversions 0 0.87055336 0.527670528 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Pentose phosphate pathway -0.606956522 -0.712450593 -0.682110682 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Phenylalanine metabolism 0 0.678853755 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Purine metabolism 0 0.445652174 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Pyrimidine metabolism 0 0.685770751 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Selenocompound metabolism 0.513913043 0 0.645302445 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Starch and sucrose metabolism -0.515652174 -0.780632411 -0.422136422 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Steroid biosynthesis 0.713043478 0.516798419 0.482625483 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Steroid hormone biosynthesis 0 0.461462451 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Synthesis and degradation of ketone bodies 0.476521739 0.663043478 0.581467181 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Tryptophan metabolism 0 0.509881423 0 kegg kegg NA NA no no no no up no N-Glycan biosynthesis Tyrosine metabolism 0 0.62055336 0 kegg kegg NA NA no no no no no no N-Glycan biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis 0 0.66798419 0.584555985 kegg kegg NA NA no no no no no no N-Glycan biosynthesis "Valine, leucine and isoleucine degradation" 0 0.755928854 0.472586873 kegg kegg NA NA no no no no no no n3+blood 14:0/18:0-PC+blood 0 -0.556372549 0 serum_fattyacid serum_phospholipids 0.806 0.00289 no no no up up no n3+blood 14:0/18:2-PC+blood 0.54887218 0 0 serum_fattyacid serum_phospholipids 0.806 0.102 no no no no up no n3+blood 14:0/20:4-PC+blood 0.536842105 0 0 serum_fattyacid serum_phospholipids 0.806 0.486 no no no no no no n3+blood 14:0+blood 0.497744361 0 0 yes serum_fattyacid serum_fattyacid 0.806 0.00572 no no no up no dn n3+blood 16:0-LPE+blood 0 0 -0.418119658 serum_fattyacid serum_phospholipids 0.806 0.0711 no no no up up no n3+blood 16:0/16:0-PI+blood 0 -0.632352941 0 serum_fattyacid serum_phospholipids 0.806 0.358 no no no no no no n3+blood 16:0/16:1-PC+blood 0 -0.512254902 0 serum_fattyacid serum_phospholipids 0.806 0.00283 no no no up up no n3+blood 16:0/16:1-PI+blood 0 -0.50245098 0 serum_fattyacid serum_phospholipids 0.806 0.262 no no no no no no n3+blood 16:0/18:0-PS+blood 0 0.620098039 0 serum_fattyacid serum_phospholipids 0.806 0.377 no no no no no no n3+blood 16:0/20:5-PC+blood 0.693233083 0.720588235 0.462564103 serum_fattyacid serum_phospholipids 0.806 0.628 no no no no no no n3+blood 16:0/22:0-PE+blood 0.505263158 0.610294118 0 serum_fattyacid serum_phospholipids 0.806 0.00839 no no no dn no up n3+blood 16:0/22:6-PC+blood 0.592481203 0.796568627 0.652649573 serum_fattyacid serum_phospholipids 0.806 4.53E-05 no no no no up up n3+blood 16:1/16:0-PC+blood 0 0.598039216 0 serum_fattyacid serum_phospholipids 0.806 0.0215 no no no no up up n3+blood 16:1/16:1-PC+blood 0 0.524509804 0 serum_fattyacid serum_phospholipids 0.806 0.0177 no no no no no up n3+blood 18:0-LPE+blood 0 0 -0.410598291 serum_fattyacid serum_phospholipids 0.806 0.491 no no no no no no n3+blood 18:0/18:0-PS+blood 0 0.551470588 0 serum_fattyacid serum_phospholipids 0.806 0.00617 no no no no up no n3+blood 18:0/20:4-PC+blood 0 0.651960784 0 serum_fattyacid serum_phospholipids 0.806 0.454 no no no no no no n3+blood 18:0/20:4-PI+blood 0 0.56127451 0 serum_fattyacid serum_phospholipids 0.806 0.167 no no no no no no n3+blood 18:0/20:5-PC+blood 0 0.647058824 0 serum_fattyacid serum_phospholipids 0.806 0.17 no no no no no no n3+blood 18:0/22:6-PC+blood 0.682706767 0.781862745 0.69982906 serum_fattyacid serum_phospholipids 0.806 0.0775 no no no no no up n3+blood 18:0/22:6-PE+blood 0 0.723039216 0 serum_fattyacid serum_phospholipids 0.806 0.00022 no no no up up no n3+blood 18:0/22:6-PI+blood 0.684210526 0.732843137 0.613675214 serum_fattyacid serum_phospholipids 0.806 0.425 no no no no no no n3+blood 18:1-LPC+blood -0.512781955 0 0 serum_fattyacid serum_phospholipids 0.806 0.179 no no no no no no n3+blood 18:1-LPE+blood 0 -0.507352941 -0.44957265 serum_fattyacid serum_phospholipids 0.806 0.117 no no no no no no n3+blood 18:1/16:0-PI+blood 0 -0.553921569 0 serum_fattyacid serum_phospholipids 0.806 0.793 no no no no no no n3+blood 18:1/18:0-PS+blood 0 0.607843137 0 serum_fattyacid serum_phospholipids 0.806 0.193 no no no no no no n3+blood 18:1/20:3-PC+blood 0 -0.553921569 0 serum_fattyacid serum_phospholipids 0.806 0.00872 no no no no up up n3+blood 18:1/20:4-PC+blood 0 0.615196078 0 serum_fattyacid serum_phospholipids 0.806 0.582 no no no no no no n3+blood 18:1/22:6-PE+blood 0 0.649509804 0.405128205 serum_fattyacid serum_phospholipids 0.806 0.0047 no no no no up no n3+blood 18:2-LPE+blood 0 -0.575980392 0 serum_fattyacid serum_phospholipids 0.806 0.112 no no no no no no n3+blood 18:2/18:1-PC+blood -0.454135338 0 0 serum_fattyacid serum_phospholipids 0.806 2.30E-05 no no no dn up up n3+blood 18:3n3+blood 0 0.566176471 0 serum_fattyacid serum_fattyacid 0.806 0.291 no no no no no no n3+blood 20:0/20:4-PE+blood 0 0 -0.567179487 serum_fattyacid serum_phospholipids 0.806 0.00128 no no no up up no n3+blood 20:0+blood -0.541353383 0 0 yes serum_fattyacid serum_fattyacid 0.806 0.000278 no no no dn no up n3+blood 20:1/20:4-PC+blood 0.563909774 0.580882353 0.613675214 serum_fattyacid serum_phospholipids 0.806 0.0419 no no no no no up n3+blood 20:1/20:4-PE+blood 0 0 -0.405811966 serum_fattyacid serum_phospholipids 0.806 0.0042 no no no up up no n3+blood 20:2-LPC+blood -0.55037594 0 0 serum_fattyacid serum_phospholipids 0.806 0.119 no no no no no up n3+blood 20:2/18:0-PC+blood 0.479699248 0 0 serum_fattyacid serum_phospholipids 0.806 0.0427 no no no no up no n3+blood 20:3-LPC+blood 0 -0.620098039 -0.470769231 serum_fattyacid serum_phospholipids 0.806 0.0292 no no no no up no n3+blood 20:3-LPE+blood 0 -0.691176471 -0.597264957 serum_fattyacid serum_phospholipids 0.806 0.084 no no no no up no n3+blood 20:3/16:0-PC+blood -0.464661654 0 0 serum_fattyacid serum_phospholipids 0.806 0.00405 no no no no up up n3+blood 20:3/18:0-PC+blood 0.446616541 0 0 serum_fattyacid serum_phospholipids 0.806 0.296 no no no no no no n3+blood 20:3/18:0-PI+blood 0 0.514705882 0 serum_fattyacid serum_phospholipids 0.806 0.289 no no no no no no n3+blood 20:4-LPE+blood 0 0 -0.497435897 serum_fattyacid serum_phospholipids 0.806 0.552 no no no no no no n3+blood 20:4n6+blood 0 0.632352941 0 serum_fattyacid serum_fattyacid 0.806 0.133 no no no no no no n3+blood 20:5-LPC+blood 0.633082707 0.639705882 0.574700855 serum_fattyacid serum_phospholipids 0.806 0.558 no no no no no no n3+blood 20:5/18:0-PC+blood 0.511278195 0.718137255 0.545982906 serum_fattyacid serum_phospholipids 0.806 3.97E-06 no no no no up up n3+blood 20:5n3+blood 0.730827068 0.816176471 0.579487179 serum_fattyacid serum_fattyacid 0.806 0.988 no no no no no no n3+blood 22:0/16:0-PE+blood 0.72481203 0.556372549 0 serum_fattyacid serum_phospholipids 0.806 0.091 no no no no no up n3+blood 22:6-LPC+blood 0.54887218 0.718137255 0.787350427 serum_fattyacid serum_phospholipids 0.806 0.127 no no no no no up n3+blood 22:6n3+blood 0.921804511 0.946078431 0.915897436 serum_fattyacid serum_fattyacid 0.806 0.792 no no no no no no n3+blood 5-HETE+blood 0 0 0.429848155 serum_fattyacid serum_ARA 0.806 0.697 no no no no no no n3+blood acetic acid C2+blood 0.485714286 0 0 serum_fattyacid serum_scfa 0.806 0.000193 no no no up dn no n3+blood Amyotrophic lateral sclerosis -0.468421053 0 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood Bacteroides 0 0 0.429059829 LPS-producing serum_fattyacid Genus 0.806 0.000267 no no no dn dn up n3+blood Calcium signaling pathway 0 -0.591176471 0 serum_fattyacid kegg 0.806 NA no no no no up up n3+blood cAMP signaling pathway 0 -0.532352941 0 yes serum_fattyacid kegg 0.806 NA no no no no up up n3+blood Choline+blood -0.460150376 0 0 serum_fattyacid serum_choline 0.806 0.0395 no no no no up no n3+blood Cholinergic synapse 0 0.629411765 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood Coronavirus disease - COVID-19 -0.503508772 0 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood Cytosolic DNA-sensing pathway 0 -0.523529412 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood d18:0-16:0-SM+blood 0 0 -0.425641026 serum_fattyacid serum_phospholipids 0.806 0.202 no no no no no no n3+blood d18:1-16:0-SM+blood 0 0 -0.476239316 serum_fattyacid serum_phospholipids 0.806 0.14 no no no no no no n3+blood d18:1-16:1-SM+blood 0 0 -0.401709402 serum_fattyacid serum_phospholipids 0.806 0.2 no no no no no no n3+blood d18:1-18:0-SM+blood 0 0.512254902 0 serum_fattyacid serum_phospholipids 0.806 0.97 no no no no no no n3+blood decanoic acid C10+blood 0 -0.68872549 0 serum_fattyacid serum_mcfa 0.806 6.64E-11 no no no dn dn no n3+blood DMG+blood 0 -0.556372549 0 serum_fattyacid serum_choline 0.806 0.909 no no no no no no n3+blood EPA+blood 0.663157895 0.74754902 0.534358974 serum_fattyacid serum_ARA 0.806 0.212 no no no no no no n3+blood HDCA+stool -0.554945055 0 0 serum_fattyacid stool_bileacids 0.806 0.176 no no no no no no n3+blood Hepatitis C 0 -0.555882353 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood Hypotaurine+blood -0.595488722 0 0 serum_fattyacid serum_aminoacids 0.806 0.933 no no no no no no n3+blood iso-LCA+blood -0.616981919 0 0 serum_fattyacid serum_bileacids 0.806 0.507 no no no no no no n3+blood isocapric acid iso-C6+blood 0 0 -0.513846154 serum_fattyacid serum_scfa 0.806 0.0458 no no no no no dn n3+blood isovaleric acid iso-C5+blood 0 0.509803922 0 serum_fattyacid serum_scfa 0.806 0.117 no no no no no no n3+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.711764706 0 serum_fattyacid kegg 0.806 NA no no no no no dn n3+blood L-Aspartic acid+blood 0 0 0.47008547 yes serum_fattyacid serum_aminoacids 0.806 0.0226 no no no up up no n3+blood L-Histidine+blood 0 -0.56127451 0 serum_fattyacid serum_aminoacids 0.806 0.109 no no no no no no n3+blood L-Isoleucine+blood 0 0 0.419487179 yes serum_fattyacid serum_aminoacids 0.806 5.47E-06 no no no up up no n3+blood L-Phenylalanine+blood 0 0 0.448205128 yes serum_fattyacid serum_aminoacids 0.806 0.0103 no no no up up no n3+blood L-Phenylalanine+stool 0 0 0.455639098 serum_fattyacid stool_cometabolism 0.806 0.398 no no no no no no n3+blood L-Tryptophan+stool 0 0 0.472180451 serum_fattyacid stool_cometabolism 0.806 0.557 no no no no no no n3+blood LCA+blood -0.524595303 0 0 serum_fattyacid serum_bileacids 0.806 0.884 no no no no no no n3+blood Malaria 0 -0.529411765 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood MAPK signaling pathway 0 0.579411765 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood Methanobrevibacter 0 0 0.413664024 serum_fattyacid Genus 0.806 0.629 no no no no no no n3+blood Mineral absorption 0 -0.647058824 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood Mitophagy - animal 0 -0.605882353 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood Necroptosis 0 -0.617647059 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood nutriCA+stool 0 0 -0.448120301 serum_fattyacid stool_bileacids 0.806 0.481 no no no no no no n3+blood Oxidative phosphorylation -0.459649123 0 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood Parkinson disease -0.461403509 0 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood Pathways of neurodegeneration - multiple diseases -0.471929825 0 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood Pertussis 0.49122807 0 0 serum_fattyacid kegg 0.806 NA no no no no no dn n3+blood Renal cell carcinoma 0 -0.526470588 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood Ribosome -0.503508772 0 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood Ruminococcus 0 -0.487745098 0 acetate-producing serum_fattyacid Genus 0.806 0.335 no no no no no no n3+blood Shigellosis -0.468421053 -0.688235294 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood Thermogenesis -0.524561404 0 0 serum_fattyacid kegg 0.806 NA no no no no no no n3+blood Ubiquitin mediated proteolysis 0 -0.544117647 0 serum_fattyacid kegg 0.806 NA no no no no no no n6/n3+blood "12,13-EPOME+blood" 0 0 -0.448773013 serum_fattyacid serum_ARA 0.226 0.901 no no no no no no n6/n3+blood 13-HODE+blood 0.508270677 0.509803922 0 serum_fattyacid serum_ARA 0.226 0.32 no no no no no no n6/n3+blood 14:0/18:2-PC+blood -0.538345865 0 0 serum_fattyacid serum_phospholipids 0.226 0.102 no no no no up no n6/n3+blood 14:0/20:4-PC+blood -0.538345865 0 0 serum_fattyacid serum_phospholipids 0.226 0.486 no no no no no no n6/n3+blood 16:0/14:0-PC+blood 0.508270677 0 0 serum_fattyacid serum_phospholipids 0.226 0.0206 no no no no up up n6/n3+blood 16:0/16:0-PI+blood -0.472180451 0 0 serum_fattyacid serum_phospholipids 0.226 0.358 no no no no no no n6/n3+blood 16:0/16:1-PI+blood -0.512781955 0 0 serum_fattyacid serum_phospholipids 0.226 0.262 no no no no no no n6/n3+blood 16:0/18:0-PS+blood 0 -0.68627451 0 serum_fattyacid serum_phospholipids 0.226 0.377 no no no no no no n6/n3+blood 16:0/18:1-PC+blood 0.457142857 0 0 serum_fattyacid serum_phospholipids 0.226 6.15E-07 no no no up up up n6/n3+blood 16:0/20:3-PC+blood 0 0 0.658119658 serum_fattyacid serum_phospholipids 0.226 5.43E-06 no no no no up up n6/n3+blood 16:0/20:4-PC+blood 0.55037594 0 0 serum_fattyacid serum_phospholipids 0.226 0.0262 no no no no up no n6/n3+blood 16:0/20:4-PI+blood -0.487218045 0 0 serum_fattyacid serum_phospholipids 0.226 0.558 no no no no no no n6/n3+blood 16:0/20:5-PC+blood -0.77443609 -0.769607843 -0.764786325 serum_fattyacid serum_phospholipids 0.226 0.628 no no no no no no n6/n3+blood 16:0/20:5-PG+blood 0.577443609 0 0 serum_fattyacid serum_phospholipids 0.226 0.00656 no no no no up no n6/n3+blood 16:0/22:0-PE+blood 0 -0.56372549 0 serum_fattyacid serum_phospholipids 0.226 0.00839 no no no dn no up n6/n3+blood 16:0/22:6-PC+blood 0 -0.573529412 0 serum_fattyacid serum_phospholipids 0.226 4.53E-05 no no no no up up n6/n3+blood 16:0/22:6-PE+blood 0 -0.524509804 0 serum_fattyacid serum_phospholipids 0.226 0.000934 no no no up up no n6/n3+blood 16:1/18:1-PG+blood 0.547368421 0 0 serum_fattyacid serum_phospholipids 0.226 3.21E-05 no no no no up up n6/n3+blood 16:1/18:2-PG+blood 0.685714286 0 0 serum_fattyacid serum_phospholipids 0.226 1.40E-08 no no no no up up n6/n3+blood 18:0/18:0-PE+blood -0.473684211 0 0 serum_fattyacid serum_phospholipids 0.226 0.00896 no no no up up no n6/n3+blood 18:0/18:0-PS+blood 0 -0.708333333 -0.408547009 serum_fattyacid serum_phospholipids 0.226 0.00617 no no no no up no n6/n3+blood 18:0/18:1-PE+blood -0.472180451 0 0 serum_fattyacid serum_phospholipids 0.226 0.00716 no no no up up no n6/n3+blood 18:0/20:3-PI+blood 0.506766917 0 0 serum_fattyacid serum_phospholipids 0.226 0.377 no no no no no no n6/n3+blood 18:0/20:4-PI+blood 0.47518797 0 0 serum_fattyacid serum_phospholipids 0.226 0.167 no no no no no no n6/n3+blood 18:0/22:6-PA+blood 0 -0.49754902 0 serum_fattyacid serum_phospholipids 0.226 0.22 no no no no no no n6/n3+blood 18:0/22:6-PC+blood 0 -0.823529412 -0.541196581 serum_fattyacid serum_phospholipids 0.226 0.0775 no no no no no up n6/n3+blood 18:0/22:6-PE+blood 0 -0.740196078 0 serum_fattyacid serum_phospholipids 0.226 0.00022 no no no up up no n6/n3+blood 18:0/22:6-PI+blood -0.529323308 -0.759803922 -0.513162393 serum_fattyacid serum_phospholipids 0.226 0.425 no no no no no no n6/n3+blood 18:1-LPC+blood 0.727819549 0 0 serum_fattyacid serum_phospholipids 0.226 0.179 no no no no no no n6/n3+blood 18:1-LPE+blood 0 0.487745098 0 serum_fattyacid serum_phospholipids 0.226 0.117 no no no no no no n6/n3+blood 18:1/18:1-PC+blood 0.478195489 0 0.667692308 serum_fattyacid serum_phospholipids 0.226 1.34E-05 no no no no up up n6/n3+blood 18:1/18:2-PG+blood 0.642105263 0 0 serum_fattyacid serum_phospholipids 0.226 5.58E-07 no no no no up up n6/n3+blood 18:1/20:3-PC+blood 0 0.517156863 0.617777778 serum_fattyacid serum_phospholipids 0.226 0.00872 no no no no up up n6/n3+blood 18:1/20:4-PC+blood 0 -0.504901961 0 serum_fattyacid serum_phospholipids 0.226 0.582 no no no no no no n6/n3+blood 18:2-LPA+blood 0 0.600490196 0 serum_fattyacid serum_phospholipids 0.226 0.00684 no no no dn no up n6/n3+blood 18:2-LPC+blood 0.511278195 0 0 serum_fattyacid serum_phospholipids 0.226 0.00743 no no no dn no up n6/n3+blood 18:2-LPE+blood 0 0.723039216 0 serum_fattyacid serum_phospholipids 0.226 0.112 no no no no no no n6/n3+blood 18:2/16:0-PC+blood 0.445112782 0 0 serum_fattyacid serum_phospholipids 0.226 8.67E-05 no no no no up up n6/n3+blood 18:2/18:1-PC+blood 0.554887218 0 0.407179487 serum_fattyacid serum_phospholipids 0.226 2.30E-05 no no no dn up up n6/n3+blood 18:2/18:2-PC+blood 0.473684211 0 0 serum_fattyacid serum_phospholipids 0.226 1.98E-05 no no no dn up up n6/n3+blood 20:0/20:4-PE+blood 0 0 0.418803419 serum_fattyacid serum_phospholipids 0.226 0.00128 no no no up up no n6/n3+blood 20:0/20:5-PC+blood 0 -0.691176471 0 serum_fattyacid serum_phospholipids 0.226 0.882 no no no no no no n6/n3+blood 20:0+blood 0.467669173 0 0 yes serum_fattyacid serum_fattyacid 0.226 0.000278 no no no dn no up n6/n3+blood 20:1/20:4-PC+blood 0 -0.578431373 0 serum_fattyacid serum_phospholipids 0.226 0.0419 no no no no no up n6/n3+blood 20:2-LPC+blood 0.67518797 0 0.456410256 serum_fattyacid serum_phospholipids 0.226 0.119 no no no no no up n6/n3+blood 20:2/18:0-PC+blood -0.463157895 0 0 serum_fattyacid serum_phospholipids 0.226 0.0427 no no no no up no n6/n3+blood 20:2+blood 0.455639098 0.654411765 0 serum_fattyacid serum_fattyacid 0.226 0.478 no no no no no no n6/n3+blood 20:3-LPE+blood 0 0.56127451 0.503589744 serum_fattyacid serum_phospholipids 0.226 0.084 no no no no up no n6/n3+blood 20:3/16:0-PC+blood 0.633082707 0 0 serum_fattyacid serum_phospholipids 0.226 0.00405 no no no no up up n6/n3+blood 20:3/18:0-PI+blood 0.47518797 0 0 serum_fattyacid serum_phospholipids 0.226 0.289 no no no no no no n6/n3+blood 20:4-LPE+blood 0 0 0.415384615 serum_fattyacid serum_phospholipids 0.226 0.552 no no no no no no n6/n3+blood 20:5-LPC+blood -0.735338346 -0.536764706 -0.790769231 serum_fattyacid serum_phospholipids 0.226 0.558 no no no no no no n6/n3+blood 20:5n3+blood -0.816541353 -0.772058824 -0.825641026 serum_fattyacid serum_fattyacid 0.226 0.988 no no no no no no n6/n3+blood 22:0/16:0-PE+blood -0.446616541 0 0 serum_fattyacid serum_phospholipids 0.226 0.091 no no no no no up n6/n3+blood 22:6-LPC+blood 0 -0.62254902 -0.652649573 serum_fattyacid serum_phospholipids 0.226 0.127 no no no no no up n6/n3+blood 22:6n3+blood -0.790977444 -0.742647059 -0.673162393 serum_fattyacid serum_fattyacid 0.226 0.792 no no no no no no n6/n3+blood 5-HETE+blood 0 0 -0.604120193 serum_fattyacid serum_ARA 0.226 0.697 no no no no no no n6/n3+blood Adipocytokine signaling pathway 0 0.517647059 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood Bacteroides 0 -0.661764706 0 LPS-producing serum_fattyacid Genus 0.226 0.000267 no no no dn dn up n6/n3+blood Betaine+blood 0.554887218 0 0 serum_fattyacid serum_choline 0.226 0.857 no no no no no no n6/n3+blood cAMP signaling pathway 0 0.717647059 0 yes serum_fattyacid kegg 0.226 NA no no no no up up n6/n3+blood Chagas disease 0 0.514705882 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood Choline+blood 0.521804511 0.647058824 0 serum_fattyacid serum_choline 0.226 0.0395 no no no no up no n6/n3+blood Cholinergic synapse 0 -0.588235294 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood Coprococcus -0.568421053 0 0 butyrate-producing serum_fattyacid Genus 0.226 0.612 no no no no no no n6/n3+blood Creatinine+blood 0.520300752 0 0 serum_fattyacid serum_choline 0.226 0.437 no no no no no no n6/n3+blood Cystine+blood 0 0.490196078 0 yes serum_fattyacid serum_aminoacids 0.226 0.00028 no no no up up no n6/n3+blood Cytosolic DNA-sensing pathway 0 0.576470588 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood d18:1-14:0-SM+blood 0 -0.56127451 0 serum_fattyacid serum_phospholipids 0.226 0.94 no no no no no no n6/n3+blood d18:1-14:1-SM+blood 0 -0.526960784 0 serum_fattyacid serum_phospholipids 0.226 0.0952 no no no no dn no n6/n3+blood d18:1-18:1-SM+blood 0.445112782 0 0 serum_fattyacid serum_phospholipids 0.226 0.916 no no no no no no n6/n3+blood d18:1-20:0-SM+blood 0 -0.504901961 0 serum_fattyacid serum_phospholipids 0.226 0.933 no no no no no no n6/n3+blood d18:1-20:1-SM+blood 0.506766917 0 0 serum_fattyacid serum_phospholipids 0.226 0.0992 no no no no no no n6/n3+blood decanoic acid C10+blood 0 0.698529412 0 serum_fattyacid serum_mcfa 0.226 6.64E-11 no no no dn dn no n6/n3+blood EPA+blood -0.47518797 -0.482843137 -0.656068376 serum_fattyacid serum_ARA 0.226 0.212 no no no no no no n6/n3+blood Ethanolamine+blood 0 0.546568627 0 serum_fattyacid serum_aminoacids 0.226 0.122 no no no up no no n6/n3+blood Ferroptosis 0 0.505882353 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood HDCA+blood 0 0 -0.46354705 serum_fattyacid serum_bileacids 0.226 0.483 no no no no no no n6/n3+blood Hepatitis C 0 0.591176471 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood heptanoic acid C7+blood 0 0.610294118 0 serum_fattyacid serum_mcfa 0.226 8.27E-11 no no no dn dn no n6/n3+blood Human cytomegalovirus infection 0 0.55 0 serum_fattyacid kegg 0.226 NA no no no no no dn n6/n3+blood Human immunodeficiency virus 1 infection 0 0.505882353 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood Hypotaurine+blood 0.467669173 0.62745098 0 serum_fattyacid serum_aminoacids 0.226 0.933 no no no no no no n6/n3+blood iso-DCA+blood 0.577443609 0 0 serum_fattyacid serum_bileacids 0.226 0.38 no no no no no no n6/n3+blood isocapric acid iso-C6+blood 0 0 0.460512821 serum_fattyacid serum_scfa 0.226 0.0458 no no no no no dn n6/n3+blood Kaposi sarcoma-associated herpesvirus infection 0 0.797058824 0 serum_fattyacid kegg 0.226 NA no no no no no dn n6/n3+blood L-Asparagine+blood 0 0.654411765 0 serum_fattyacid serum_aminoacids 0.226 0.784 no no no no no no n6/n3+blood L-Glutamic acid+blood 0 0.485294118 0 yes serum_fattyacid serum_aminoacids 0.226 6.20E-05 no no no up up no n6/n3+blood L-Histidine+blood 0.482706767 0.754901961 0 serum_fattyacid serum_aminoacids 0.226 0.109 no no no no no no n6/n3+blood L-Isoleucine+blood 0 0.632352941 0 yes serum_fattyacid serum_aminoacids 0.226 5.47E-06 no no no up up no n6/n3+blood L-Lysine+blood 0 0.507352941 0 yes serum_fattyacid serum_aminoacids 0.226 0.0107 no no no no up no n6/n3+blood lauric acid C12+blood 0.490225564 0.632352941 0 serum_fattyacid serum_mcfa 0.226 0.015 no no no no dn dn n6/n3+blood Long-term depression 0 0.561764706 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood Malaria 0 0.576470588 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood MAPK signaling pathway 0 -0.505882353 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood MUFA%+blood 0.491729323 0 0 serum_fattyacid serum_fattyacid 0.226 0.00142 no no no up no dn n6/n3+blood n3+blood -0.836090226 -0.742647059 -0.717606838 serum_fattyacid serum_fattyacid 0.226 0.806 no no no no no no n6/n3+blood Necroptosis 0 0.55 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood Phenylacetic acid+stool 0.587912088 0 0 serum_fattyacid stool_cometabolism 0.226 0.785 no no no no no no n6/n3+blood Primary immunodeficiency 0 -0.505882353 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood Progesterone-mediated oocyte maturation 0 -0.544117647 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood Propionic acid+stool 0 0 -0.512781955 yes serum_fattyacid stool_scfa 0.226 0.0436 no no no dn no up n6/n3+blood Ras signaling pathway 0 -0.585294118 0 yes serum_fattyacid kegg 0.226 NA no no no no up up n6/n3+blood Relaxin signaling pathway 0 0.535294118 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood Shigellosis 0 0.594117647 0 serum_fattyacid kegg 0.226 NA no no no no no no n6/n3+blood total_stool_scfa+stool 0 0 -0.45112782 serum_fattyacid stool_scfa 0.226 0.0534 no no no dn no up n6+blood 12-ketoDCA+blood -0.537758775 0 0 serum_fattyacid serum_bileacids 0.153 0.517 no no no no no no n6+blood 13-HODE+blood 0.457142857 0 0 serum_fattyacid serum_ARA 0.153 0.32 no no no no no no n6+blood 14:0/16:0-PC+blood 0 0 0.402393162 serum_fattyacid serum_phospholipids 0.153 0.0358 no no no no up no n6+blood 14:0/18:2-PC+blood 0 0 0.499487179 serum_fattyacid serum_phospholipids 0.153 0.102 no no no no up no n6+blood 14:0+blood 0.517293233 0 0.549401709 yes serum_fattyacid serum_fattyacid 0.153 0.00572 no no no up no dn n6+blood 16:0+blood 0.815037594 0.884803922 0.688205128 yes serum_fattyacid serum_fattyacid 0.153 0.00876 no no no up no no n6+blood 16:1/18:2-PG+blood 0 0.5 -0.434529915 serum_fattyacid serum_phospholipids 0.153 1.40E-08 no no no no up up n6+blood 16:1+blood 0.559398496 0 0 yes serum_fattyacid serum_fattyacid 0.153 0.0186 no no no no no dn n6+blood 18:0/18:2-PC+blood 0 0.490196078 0 serum_fattyacid serum_phospholipids 0.153 1.74E-06 no no no no up up n6+blood 18:0+blood 0.67518797 0.718137255 0.600683761 serum_fattyacid serum_fattyacid 0.153 0.344 no no no no no no n6+blood 18:1/18:0-PC+blood 0 0.512254902 0 serum_fattyacid serum_phospholipids 0.153 1.83E-06 no no no no up up n6+blood 18:1/18:0-PS+blood 0 0.578431373 0 serum_fattyacid serum_phospholipids 0.153 0.193 no no no no no no n6+blood 18:1/18:1-PG+blood 0 0 -0.483760684 serum_fattyacid serum_phospholipids 0.153 0.00352 no no no no up up n6+blood 18:1+blood 0.720300752 0 0.463247863 yes serum_fattyacid serum_fattyacid 0.153 0.00202 no no no up no dn n6+blood 18:2/16:0-PC+blood 0 0.566176471 0 serum_fattyacid serum_phospholipids 0.153 8.67E-05 no no no no up up n6+blood 18:2/18:1-PC+blood 0 0.492647059 0 serum_fattyacid serum_phospholipids 0.153 2.30E-05 no no no dn up up n6+blood 18:2n6c+blood 0.769924812 0.901960784 0.826324786 serum_fattyacid serum_fattyacid 0.153 0.15 no no no no no no n6+blood 18:3n3+blood 0.494736842 0 0 serum_fattyacid serum_fattyacid 0.153 0.291 no no no no no no n6+blood 20:0/20:5-PC+blood 0 -0.514705882 0 serum_fattyacid serum_phospholipids 0.153 0.882 no no no no no no n6+blood 20:1-LPA+blood 0 0 -0.45025641 serum_fattyacid serum_phospholipids 0.153 0.0187 no no no dn dn no n6+blood 20:2/18:3-PE+blood 0 0.492647059 0 serum_fattyacid serum_phospholipids 0.153 0.0391 no no no up up no n6+blood 20:2+blood 0 0.56127451 0 serum_fattyacid serum_fattyacid 0.153 0.478 no no no no no no n6+blood 20:3-LPE+blood 0.515789474 0 0 serum_fattyacid serum_phospholipids 0.153 0.084 no no no no up no n6+blood 20:4-LPA+blood 0.445112782 0 0 serum_fattyacid serum_phospholipids 0.153 0.398 no no no no no no n6+blood 20:4/18:0-PE+blood 0 0.482843137 0 serum_fattyacid serum_phospholipids 0.153 0.000755 no no no up up no n6+blood 20:4n6+blood 0 0.49754902 0 serum_fattyacid serum_fattyacid 0.153 0.133 no no no no no no n6+blood 24:0+blood 0 0.485294118 0 serum_fattyacid serum_fattyacid 0.153 0.034 no no no dn no up n6+blood AA+blood 0.496240602 0 0 serum_fattyacid serum_ARA 0.153 0.212 no no no no no no n6+blood Adipocytokine signaling pathway 0 0 0.426153846 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood AGE-RAGE signaling pathway in diabetic complications 0.478947368 0 0 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood AMPK signaling pathway 0 0 0.484615385 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood Bifidobacterium 0 -0.606989691 0 acetate-producing serum_fattyacid Genus 0.153 0.105 no no no no dn no n6+blood Biosynthesis of cofactors 0 0 0.622307692 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood Cardiac muscle contraction 0 0 -0.409230769 serum_fattyacid kegg 0.153 NA no no no no no up n6+blood DCA+blood -0.445112782 0 0 serum_fattyacid serum_bileacids 0.153 0.122 no no no no no no n6+blood Focal adhesion 0 0 -0.407692308 serum_fattyacid kegg 0.153 NA no no no no up up n6+blood GCDCA+blood 0 0 -0.411282051 serum_fattyacid serum_bileacids 0.153 0.31 no no no no no no n6+blood GLCA+blood 0 0 -0.447825769 serum_fattyacid serum_bileacids 0.153 0.319 no no no no no no n6+blood Glutathione metabolism 0 0 0.537692308 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood "Glycine, serine and threonine metabolism" 0 -0.647058824 0.596923077 serum_fattyacid kegg 0.153 NA no no no no up no n6+blood Kaposi sarcoma-associated herpesvirus infection -0.470175439 0 0 serum_fattyacid kegg 0.153 NA no no no no no dn n6+blood L-Proline+blood 0 0 -0.440683761 yes serum_fattyacid serum_aminoacids 0.153 0.00265 no no no up up no n6+blood Lipid and atherosclerosis 0.456140351 0 0 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood Longevity regulating pathway 0 0 0.472307692 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood Malaria 0 0 0.409230769 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood Mitophagy - animal -0.459649123 0 0 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood MUFA+blood 0.735338346 0 0.455726496 serum_fattyacid serum_fattyacid 0.153 0.00175 no no no up no dn n6+blood NOD-like receptor signaling pathway 0.459649123 0 0 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood Pathways of neurodegeneration - multiple diseases -0.457894737 0 0 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood Porphyrin and chlorophyll metabolism 0 -0.611764706 0.615384615 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood Prevotella 0 0.563807819 0 acetate-producing serum_fattyacid Genus 0.153 0.287 no no no no no no n6+blood Ruminococcus 0 -0.580882353 0 acetate-producing serum_fattyacid Genus 0.153 0.335 no no no no no no n6+blood Shigellosis -0.596491228 0 0 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood Sphingolipid signaling pathway 0 0 -0.591538462 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood Thyroid hormone synthesis 0 0 0.468461538 serum_fattyacid kegg 0.153 NA no no no no no no n6+blood Ubiquitin mediated proteolysis -0.485964912 0 0.406153846 serum_fattyacid kegg 0.153 NA no no no no no no Natural killer cell mediated cytotoxicity Adrenergic signaling in cardiomyocytes 0 -0.486166008 0 kegg kegg NA NA no no no no no up Natural killer cell mediated cytotoxicity alpha-Linolenic acid metabolism 0.407826087 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity AMPK signaling pathway 0 -0.59486166 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Antigen processing and presentation 0.684347826 0.509881423 0.615186615 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Apelin signaling pathway -0.424347826 -0.416996047 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Apoptosis 0.537391304 0.752964427 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Apoptosis - multiple species -0.439130435 0 -0.602831403 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Autophagy - other -0.465217391 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Axon guidance 0 0.423913043 0 kegg kegg NA NA no no no no up up Natural killer cell mediated cytotoxicity Basal transcription factors -0.679130435 -0.601778656 -0.493951094 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Base excision repair -0.426086957 -0.524703557 -0.468468468 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Biosynthesis of amino acids 0.720869565 0.677865613 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Biosynthesis of cofactors 0 -0.845849802 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Butyricicoccus 0 0 0.419827251 butyrate-producing kegg Genus NA 0.852 no no no no no no Natural killer cell mediated cytotoxicity C-type lectin receptor signaling pathway 0 0.62055336 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Carbon metabolism 0.574782609 0.424901186 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Cardiac muscle contraction -0.417391304 0 0 kegg kegg NA NA no no no no no up Natural killer cell mediated cytotoxicity Cell adhesion molecules 0.893913043 0.951581028 0.865637066 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Cell cycle -0.612173913 -0.653162055 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Cellular senescence 0.917391304 0.975296443 0.918661519 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity cGMP-PKG signaling pathway 0 0.605731225 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Chemokine signaling pathway 0 0.540513834 0.537966538 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Complement and coagulation cascades 0.725217391 0.627470356 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Cytosolic DNA-sensing pathway 0 0 0.542084942 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity DNA replication 0 -0.517786561 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Drug metabolism - cytochrome P450 0 -0.429841897 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Endocrine resistance 0 -0.500988142 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Endocytosis 0.952173913 0.971343874 0.951608752 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Ether lipid metabolism -0.583478261 -0.756916996 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Fanconi anemia pathway -0.470434783 -0.578063241 -0.452767053 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity FoxO signaling pathway 0 0 -0.493436293 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Galactose metabolism 0 0.419960474 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Glutathione metabolism 0 -0.604743083 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Glycerophospholipid metabolism -0.666956522 0 0 kegg kegg NA NA no no no no no up Natural killer cell mediated cytotoxicity "Glycine, serine and threonine metabolism" 0 -0.735177866 0 kegg kegg NA NA no no no no up no Natural killer cell mediated cytotoxicity Glycolysis / Gluconeogenesis 0.433913043 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Glycosaminoglycan degradation 0.426086957 0.54743083 0 kegg kegg NA NA no no no no no up Natural killer cell mediated cytotoxicity Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.731225296 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Glyoxylate and dicarboxylate metabolism 0 0.423913043 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Hedgehog signaling pathway -0.570434783 -0.454545455 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Homologous recombination 0 -0.489130435 -0.573230373 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Lysosome 0.43826087 0.693675889 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Mismatch repair 0 -0.60770751 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Mitophagy - animal 0 -0.502964427 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity mRNA surveillance pathway -0.682608696 -0.490118577 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity N-Glycan biosynthesis -0.460869565 -0.47826087 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Neuroactive ligand-receptor interaction 0 0.660079051 0 kegg kegg NA NA no no no up up up Natural killer cell mediated cytotoxicity Neutrophil extracellular trap formation 0.642608696 0.671936759 0.401801802 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Nicotinate and nicotinamide metabolism 0 0.499011858 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Nitrogen metabolism 0.45826087 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity NOD-like receptor signaling pathway 0 0.59486166 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Nucleotide excision repair -0.428695652 -0.650197628 -0.575289575 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity One carbon pool by folate -0.479130435 -0.619565217 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Oocyte meiosis -0.454782609 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Osteoclast differentiation 0 0.707509881 0.405662806 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Other types of O-glycan biosynthesis -0.640869565 -0.513833992 -0.405662806 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Oxidative phosphorylation -0.440869565 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity p53 signaling pathway -0.647826087 -0.416007905 -0.544658945 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Pantothenate and CoA biosynthesis 0 0.43083004 0 kegg kegg NA NA no no no no no dn Natural killer cell mediated cytotoxicity Pentose and glucuronate interconversions 0 -0.456521739 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Pentose phosphate pathway 0.669565217 0.718379447 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Phagosome 0.899130435 0.925889328 0.762676963 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Phosphatidylinositol signaling system -0.574782609 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Platinum drug resistance -0.459130435 0 -0.607464607 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Porphyrin and chlorophyll metabolism 0 -0.730237154 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity PPAR signaling pathway 0.433043478 0.556324111 0.546975547 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Protein export -0.610434783 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Protein processing in endoplasmic reticulum 0 -0.580039526 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Purine metabolism 0 -0.708498024 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Pyrimidine metabolism 0 -0.516798419 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Pyruvate metabolism 0 -0.507905138 -0.44041184 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Rap1 signaling pathway 0.474782609 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Renin-angiotensin system 0 0.721343874 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Retinol metabolism 0 -0.438735178 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Ribosome -0.489565217 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Ribosome biogenesis in eukaryotes -0.59826087 -0.577075099 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity RNA degradation -0.639130435 -0.479249012 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity RNA polymerase -0.568695652 -0.631422925 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Ruminococcus 0 0 0.434491634 acetate-producing kegg Genus NA 0.335 no no no no no no Natural killer cell mediated cytotoxicity Selenocompound metabolism -0.592173913 -0.490118577 -0.441184041 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Signaling pathways regulating pluripotency of stem cells -0.409565217 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Sphingolipid signaling pathway 0 0.756916996 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Spliceosome -0.422608696 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Steroid biosynthesis -0.648695652 -0.449604743 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Steroid hormone biosynthesis 0 -0.503952569 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Synthesis and degradation of ketone bodies 0 -0.621541502 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Taurine and hypotaurine metabolism -0.589565217 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Terpenoid backbone biosynthesis -0.655652174 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity TGF-beta signaling pathway -0.522608696 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Thiamine metabolism 0 -0.618577075 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Toll-like receptor signaling pathway 0 0.591897233 0.587644788 yes kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Tyrosine metabolism 0 -0.528656126 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.518774704 -0.408236808 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Ubiquitin mediated proteolysis 0 -0.59486166 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity "Valine, leucine and isoleucine degradation" 0 -0.480237154 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity VEGF signaling pathway 0 0.442687747 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Viral protein interaction with cytokine and cytokine receptor 0.467826087 0 0 kegg kegg NA NA no no no no no no Natural killer cell mediated cytotoxicity Wnt signaling pathway -0.434782609 -0.459486166 0 kegg kegg NA NA no no no no no no Necroptosis 2-Oxocarboxylic acid metabolism 0 0 -0.491891892 kegg kegg NA NA no no no no no no Necroptosis ABC transporters -0.46173913 0 0 kegg kegg NA NA no no no no up up Necroptosis alpha-Linolenic acid metabolism 0 0 -0.403603604 kegg kegg NA NA no no no no no no Necroptosis AMPK signaling pathway 0.447826087 0 0.658429858 kegg kegg NA NA no no no no no no Necroptosis Arachidonic acid metabolism 0 0 0.507335907 kegg kegg NA NA no no no no no no Necroptosis Ascorbate and aldarate metabolism 0 0 -0.449163449 kegg kegg NA NA no no no no no no Necroptosis Autophagy - other 0 0 -0.409009009 kegg kegg NA NA no no no no no no Necroptosis beta-Alanine metabolism -0.429565217 -0.556324111 0 kegg kegg NA NA no no no no no no Necroptosis Biosynthesis of cofactors 0 0 0.517117117 kegg kegg NA NA no no no no no no Necroptosis Biosynthesis of unsaturated fatty acids -0.493913043 -0.555335968 0 kegg kegg NA NA no no no no no no Necroptosis Butanoate metabolism -0.409565217 -0.425889328 0 kegg kegg NA NA no no no no no no Necroptosis cAMP signaling pathway 0 0.503952569 0 yes kegg kegg NA NA no no no no up up Necroptosis Carbon metabolism -0.430434783 -0.47826087 0 kegg kegg NA NA no no no no no no Necroptosis Cell cycle 0 0 -0.446074646 kegg kegg NA NA no no no no no no Necroptosis Citrate cycle (TCA cycle) -0.442608696 0 -0.4002574 kegg kegg NA NA no no no no no no Necroptosis Endocrine resistance 0.51826087 0 0 kegg kegg NA NA no no no no no no Necroptosis ErbB signaling pathway 0 0 -0.633719434 kegg kegg NA NA no no no no no no Necroptosis Fanconi anemia pathway 0 0 -0.410553411 kegg kegg NA NA no no no no no no Necroptosis Fatty acid degradation -0.430434783 0 0 kegg kegg NA NA no no no no no no Necroptosis Fatty acid elongation -0.512173913 -0.567193676 0 kegg kegg NA NA no no no no no no Necroptosis Fatty acid metabolism -0.466086957 0 0 kegg kegg NA NA no no no no no no Necroptosis Ferroptosis 0.9 0.899209486 0.95984556 kegg kegg NA NA no no no no no no Necroptosis Folate biosynthesis -0.425217391 0 0 kegg kegg NA NA no no no no no no Necroptosis Galactose metabolism -0.489565217 -0.431818182 -0.401029601 kegg kegg NA NA no no no no no no Necroptosis Glutathione metabolism 0.448695652 0 0.606949807 kegg kegg NA NA no no no no no no Necroptosis Glycerolipid metabolism 0 0 -0.6998713 kegg kegg NA NA no no no no no up Necroptosis Glycerophospholipid metabolism 0 0 -0.563191763 kegg kegg NA NA no no no no no up Necroptosis "Glycine, serine and threonine metabolism" 0 0 0.532303732 kegg kegg NA NA no no no no up no Necroptosis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.557271557 kegg kegg NA NA no no no no no no Necroptosis Glycosaminoglycan degradation 0 0 -0.545173745 kegg kegg NA NA no no no no no up Necroptosis Inositol phosphate metabolism -0.480869565 0 -0.6002574 kegg kegg NA NA no no no no no no Necroptosis Longevity regulating pathway 0.599130435 0 0.62960103 kegg kegg NA NA no no no no no no Necroptosis Longevity regulating pathway - multiple species 0 -0.556324111 0 kegg kegg NA NA no no no no no no Necroptosis Lysine degradation 0 0 -0.572458172 kegg kegg NA NA no no no no no no Necroptosis Mannose type O-glycan biosynthesis 0 0 -0.557014157 kegg kegg NA NA no no no no no no Necroptosis MAPK signaling pathway 0 0 -0.537451737 kegg kegg NA NA no no no no no no Necroptosis Mismatch repair -0.420869565 0 0 kegg kegg NA NA no no no no no no Necroptosis Mitophagy - animal 0.762608696 0.609683794 0.784041184 kegg kegg NA NA no no no no no no Necroptosis mRNA surveillance pathway 0 0 -0.404633205 kegg kegg NA NA no no no no no no Necroptosis Mucin type O-glycan biosynthesis 0 -0.429841897 0 kegg kegg NA NA no no no no no no Necroptosis N-Glycan biosynthesis 0 0 -0.518146718 kegg kegg NA NA no no no no no no Necroptosis Neuroactive ligand-receptor interaction -0.499130435 -0.442687747 0 kegg kegg NA NA no no no up up up Necroptosis NF-kappa B signaling pathway -0.477391304 0 0 kegg kegg NA NA no no no no no no Necroptosis Nitrogen metabolism 0 0 0.400772201 kegg kegg NA NA no no no no no no Necroptosis Non-homologous end-joining -0.494782609 -0.5 0 kegg kegg NA NA no no no no no no Necroptosis Odoribacter 0 -0.456167818 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Necroptosis One carbon pool by folate 0 0 -0.449163449 kegg kegg NA NA no no no no no no Necroptosis Other glycan degradation 0 0 -0.701930502 kegg kegg NA NA no no no no no no Necroptosis Other types of O-glycan biosynthesis 0 0 -0.58970399 kegg kegg NA NA no no no no no no Necroptosis Pentose and glucuronate interconversions 0 0 -0.458687259 kegg kegg NA NA no no no no no no Necroptosis Phosphatidylinositol signaling system 0 -0.480237154 -0.572458172 kegg kegg NA NA no no no no no no Necroptosis Porphyrin and chlorophyll metabolism 0.416521739 0 0.596911197 kegg kegg NA NA no no no no no no Necroptosis Primary bile acid biosynthesis -0.503478261 -0.473320158 0 kegg kegg NA NA no no no no no no Necroptosis Protein processing in endoplasmic reticulum 0 0 0.471814672 kegg kegg NA NA no no no no no no Necroptosis Purine metabolism 0.442608696 0 0.749034749 kegg kegg NA NA no no no no no no Necroptosis Ras signaling pathway 0 0 -0.410553411 yes kegg kegg NA NA no no no no up up Necroptosis Retinol metabolism 0 -0.519762846 -0.401287001 kegg kegg NA NA no no no no no no Necroptosis Ribosome 0.500869565 0 0 kegg kegg NA NA no no no no no no Necroptosis Ribosome biogenesis in eukaryotes 0 0 -0.498069498 kegg kegg NA NA no no no no no no Necroptosis RNA degradation 0 0 -0.554697555 kegg kegg NA NA no no no no no no Necroptosis Selenocompound metabolism 0 0 -0.497554698 kegg kegg NA NA no no no no no no Necroptosis Sphingolipid signaling pathway 0 0 -0.524324324 kegg kegg NA NA no no no no no no Necroptosis Spliceosome 0 0 -0.467438867 kegg kegg NA NA no no no no no no Necroptosis Sulfur metabolism 0 0 0.487516088 kegg kegg NA NA no no no no no no Necroptosis Synthesis and degradation of ketone bodies 0 -0.42687747 0 kegg kegg NA NA no no no no no no Necroptosis Terpenoid backbone biosynthesis 0 -0.456521739 0 kegg kegg NA NA no no no no no no Necroptosis Tryptophan metabolism -0.43826087 -0.635375494 0 kegg kegg NA NA no no no no up no Necroptosis Ubiquinone and other terpenoid-quinone biosynthesis -0.405217391 -0.490118577 0 kegg kegg NA NA no no no no no no Necroptosis Ubiquitin mediated proteolysis 0.669565217 0.531620553 0.771943372 kegg kegg NA NA no no no no no no Necroptosis "Valine, leucine and isoleucine degradation" -0.430434783 -0.445652174 0 kegg kegg NA NA no no no no no no Necroptosis Various types of N-glycan biosynthesis 0 0 -0.635263835 kegg kegg NA NA no no no no no no Neuroactive ligand-receptor interaction "Alanine, aspartate and glutamate metabolism" 0 0.433794466 0.535907336 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Amino sugar and nucleotide sugar metabolism 0.424347826 0 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Aminoacyl-tRNA biosynthesis 0 -0.463438735 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Antifolate resistance 0 -0.470355731 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Arginine and proline metabolism 0 0.535573123 0.524066924 kegg kegg NA NA up up up no up no Neuroactive ligand-receptor interaction Arginine biosynthesis 0 0.493083004 0.608236808 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Basal transcription factors 0 -0.536561265 -0.473101673 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Base excision repair 0 -0.517786561 -0.442728443 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Biosynthesis of amino acids 0.500869565 0.785573123 0.74002574 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Biosynthesis of cofactors 0 -0.536561265 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Calcium signaling pathway 0 -0.530632411 -0.497554698 kegg kegg NA NA up up up no up up Neuroactive ligand-receptor interaction Carbon metabolism 0.468695652 0.636363636 0.723037323 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction cGMP-PKG signaling pathway 0 0.783596838 0.59047619 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Chemokine signaling pathway 0 0.549407115 0.421879022 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Cysteine and methionine metabolism 0 0 -0.418532819 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Cytokine-cytokine receptor interaction 0 0.540513834 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction DNA replication 0 -0.496047431 -0.414414414 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Drug metabolism - other enzymes 0.422608696 0 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction EGFR tyrosine kinase inhibitor resistance 0 -0.494071146 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Endocrine resistance -0.517391304 -0.640316206 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction ErbB signaling pathway -0.417391304 0 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Ether lipid metabolism 0 -0.466403162 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Fanconi anemia pathway 0 -0.591897233 -0.454311454 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Fatty acid biosynthesis 0 0.504940711 0.548005148 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Fatty acid degradation 0 0.428853755 0.418790219 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Fatty acid elongation 0.457391304 0 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Fatty acid metabolism 0 0.57312253 0.445817246 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Glutathione metabolism 0 -0.509881423 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Glycerophospholipid metabolism 0 0 -0.402574003 kegg kegg NA NA up up up no no up Neuroactive ligand-receptor interaction "Glycine, serine and threonine metabolism" 0 -0.520750988 0 kegg kegg NA NA up up up no up no Neuroactive ligand-receptor interaction Glycosaminoglycan degradation 0.506086957 0.662055336 0 kegg kegg NA NA up up up no no up Neuroactive ligand-receptor interaction Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.546442688 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Glyoxylate and dicarboxylate metabolism 0 0.519762846 0.643243243 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Homologous recombination 0 -0.501976285 -0.516087516 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Lysine degradation -0.426956522 -0.666996047 -0.573230373 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Mannose type O-glycan biosynthesis -0.453043478 -0.545454545 -0.528442728 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction mRNA surveillance pathway -0.432173913 -0.747035573 -0.711196911 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Mucin type O-glycan biosynthesis 0.492173913 0 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction N-Glycan biosynthesis 0 -0.544466403 -0.533075933 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Nicotinate and nicotinamide metabolism 0 0.570158103 0.75984556 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Nitrogen metabolism 0 0.441699605 0.436550837 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Nucleotide excision repair 0 -0.468379447 -0.43037323 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Odoribacter 0 0.448738375 0 butyrate-producing kegg Genus NA 0.798 up up up no no no Neuroactive ligand-receptor interaction One carbon pool by folate 0 -0.490118577 -0.532046332 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Other types of O-glycan biosynthesis 0 -0.657114625 -0.558301158 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Oxidative phosphorylation 0 -0.475296443 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Pantothenate and CoA biosynthesis 0.586086957 0.669960474 0.748005148 kegg kegg NA NA up up up no no dn Neuroactive ligand-receptor interaction Pentose phosphate pathway 0.505217391 0.890316206 0.805148005 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Phosphatidylinositol signaling system 0 0 -0.516602317 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Porphyrin and chlorophyll metabolism 0 -0.486166008 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction PPAR signaling pathway 0 0.564229249 0.654311454 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Protein export 0 0 -0.448391248 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Purine metabolism -0.451304348 -0.610671937 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Retinol metabolism 0.473043478 0 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Ribosome -0.516521739 -0.485177866 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Ribosome biogenesis in eukaryotes -0.408695652 -0.674901186 -0.616216216 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction RNA degradation -0.409565217 -0.681818182 -0.629086229 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction RNA polymerase 0 -0.756916996 -0.473359073 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Selenocompound metabolism 0 -0.431818182 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Sphingolipid signaling pathway 0 0.586956522 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Spliceosome 0 -0.516798419 -0.586872587 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Starch and sucrose metabolism 0.566956522 0.529644269 0.489060489 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Steroid hormone biosynthesis 0.491304348 0 0 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Taurine and hypotaurine metabolism -0.413043478 0 -0.448648649 kegg kegg NA NA up up up no no no Neuroactive ligand-receptor interaction Viral protein interaction with cytokine and cytokine receptor 0 0.553359684 0 kegg kegg NA NA up up up no no no Neurotrophin signaling pathway 2-Oxocarboxylic acid metabolism -0.645217391 -0.470355731 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Adherens junction 0 -0.425889328 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Adrenergic signaling in cardiomyocytes 0.503478261 0 0 kegg kegg NA NA no no no no no up Neurotrophin signaling pathway "Alanine, aspartate and glutamate metabolism" 0 0.4743083 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway alpha-Linolenic acid metabolism -0.425217391 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Amino sugar and nucleotide sugar metabolism -0.644347826 -0.434782609 -0.504761905 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Aminoacyl-tRNA biosynthesis -0.544347826 -0.530632411 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Anaerostipes 0 0 -0.445015205 butyrate-producing kegg Genus NA 0.568 no no no no no no Neurotrophin signaling pathway Antifolate resistance -0.464347826 -0.540513834 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Apoptosis 0 0.744071146 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Arachidonic acid metabolism -0.560869565 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Arginine and proline metabolism 0 0.565217391 0 kegg kegg NA NA no no no no up no Neurotrophin signaling pathway Arginine biosynthesis 0 0.470355731 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Ascorbate and aldarate metabolism 0 -0.419960474 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Autophagy - animal 0.493913043 0.704545455 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Autophagy - other 0.589565217 0.416996047 0.432175032 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Axon guidance 0.833043478 0.4743083 0.528185328 kegg kegg NA NA no no no no up up Neurotrophin signaling pathway B cell receptor signaling pathway 0.535652174 0.858695652 0.762419562 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Basal transcription factors 0 -0.514822134 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Base excision repair 0 -0.479249012 -0.424195624 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway beta-Alanine metabolism -0.776521739 -0.557312253 -0.688030888 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Biosynthesis of amino acids -0.473043478 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Biosynthesis of cofactors -0.624347826 -0.641304348 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Biosynthesis of unsaturated fatty acids -0.651304348 -0.635375494 -0.629086229 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Butanoate metabolism -0.703478261 -0.703557312 -0.641441441 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Butyricimonas 0.406906307 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Neurotrophin signaling pathway C-type lectin receptor signaling pathway 0.790434783 0.895256917 0.816473616 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Calcium signaling pathway 0.52173913 0 0.483397683 kegg kegg NA NA no no no no up up Neurotrophin signaling pathway cAMP signaling pathway 0.770434783 0.694664032 0.648133848 yes kegg kegg NA NA no no no no up up Neurotrophin signaling pathway Carbon metabolism -0.608695652 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Cardiac muscle contraction 0.560869565 0 0 kegg kegg NA NA no no no no no up Neurotrophin signaling pathway Cell adhesion molecules 0 0.482213439 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Cell cycle 0 -0.565217391 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Cellular senescence 0 0.634387352 0.482110682 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway cGMP-PKG signaling pathway 0 0.492094862 0.544658945 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Chemokine signaling pathway 0.626086957 0.601778656 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Circadian entrainment 0 -0.746047431 0 kegg kegg NA NA no no no no up up Neurotrophin signaling pathway Circadian rhythm 0.682608696 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Citrate cycle (TCA cycle) -0.64 -0.687747036 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Collinsella 0 0 -0.413097427 kegg Genus NA 0.128 no no no no no no Neurotrophin signaling pathway Cysteine and methionine metabolism 0 -0.626482213 -0.459459459 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Cytokine-cytokine receptor interaction 0 0 -0.422651223 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Cytosolic DNA-sensing pathway 0.474782609 0.839920949 0.612870013 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway DNA replication 0 -0.741106719 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Drug metabolism - cytochrome P450 0 -0.709486166 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Drug metabolism - other enzymes -0.64 -0.572134387 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Endocytosis 0 0.489130435 0.410553411 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway ErbB signaling pathway 0.607826087 0.54743083 0.495238095 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Ether lipid metabolism 0 -0.504940711 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Fanconi anemia pathway 0 -0.523715415 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Fatty acid biosynthesis 0 0.441699605 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Fatty acid degradation -0.471304348 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Fatty acid elongation -0.644347826 -0.470355731 -0.602316602 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Fatty acid metabolism -0.546956522 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Fc epsilon RI signaling pathway 0.486086957 0.695652174 0.457142857 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Focal adhesion 0 -0.504940711 0 kegg kegg NA NA no no no no up up Neurotrophin signaling pathway Fructose and mannose metabolism -0.571304348 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Galactose metabolism -0.597391304 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Glutathione metabolism 0 -0.505928854 -0.483912484 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway "Glycine, serine and threonine metabolism" -0.468695652 -0.48715415 0 kegg kegg NA NA no no no no up no Neurotrophin signaling pathway Glycolysis / Gluconeogenesis -0.664347826 -0.42687747 -0.496010296 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.583992095 0.52020592 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.439130435 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 -0.542490119 -0.404633205 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.471304348 0 0.527155727 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.514822134 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Hedgehog signaling pathway 0 -0.421936759 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Hematopoietic cell lineage -0.548695652 0 -0.529214929 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Hippo signaling pathway 0 -0.476284585 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Hippo signaling pathway - multiple species 0 0.422924901 0.402059202 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Histidine metabolism -0.603478261 0 -0.474646075 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway IL-17 signaling pathway 0 0.511857708 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway JAK-STAT signaling pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Long-term potentiation 0.406956522 -0.431818182 0.434234234 kegg kegg NA NA no no no no no up Neurotrophin signaling pathway Longevity regulating pathway - multiple species 0 0 -0.663835264 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Lysosome 0 0.416007905 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Mannose type O-glycan biosynthesis 0.55826087 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.70256917 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Mismatch repair -0.568695652 -0.774703557 -0.538223938 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway mRNA surveillance pathway 0.566956522 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway N-Glycan biosynthesis 0 -0.550395257 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Natural killer cell mediated cytotoxicity 0 0.538537549 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway NF-kappa B signaling pathway 0 0.742094862 0.619305019 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Nicotinate and nicotinamide metabolism 0 0.473320158 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Nitrogen metabolism 0 0.499011858 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway NOD-like receptor signaling pathway 0 0.744071146 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Non-homologous end-joining -0.697391304 -0.581027668 -0.639382239 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Nucleotide excision repair -0.42 -0.801383399 -0.553667954 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway One carbon pool by folate -0.506086957 -0.827075099 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Oocyte meiosis 0 -0.538537549 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Osteoclast differentiation 0 0.649209486 0.464092664 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Oxidative phosphorylation 0.507826087 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Pentose and glucuronate interconversions -0.482608696 -0.62055336 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Phagosome 0 0.429841897 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Phenylalanine metabolism -0.689565217 -0.716403162 -0.487516088 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Phosphatidylinositol signaling system 0.433043478 -0.416996047 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Phospholipase D signaling pathway 0 0.490118577 0.47979408 kegg kegg NA NA no no no no up up Neurotrophin signaling pathway Platelet activation 0 -0.473320158 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Porphyrin and chlorophyll metabolism -0.485217391 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway PPAR signaling pathway 0 0.733201581 0.506306306 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Primary bile acid biosynthesis -0.686956522 -0.578063241 -0.520978121 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Propanoate metabolism -0.485217391 -0.595849802 -0.48005148 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Proteasome 0 -0.45256917 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Protein processing in endoplasmic reticulum 0 -0.499011858 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Purine metabolism 0 -0.416996047 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Pyrimidine metabolism -0.704347826 -0.772727273 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Pyruvate metabolism -0.607826087 -0.643280632 -0.708108108 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Ras signaling pathway 0.486956522 -0.500988142 0 yes kegg kegg NA NA no no no no up up Neurotrophin signaling pathway Renin-angiotensin system 0 0.462450593 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Retinol metabolism -0.624347826 -0.82312253 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Ribosome 0.408695652 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Ribosome biogenesis in eukaryotes 0 -0.576086957 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway RIG-I-like receptor signaling pathway 0.652173913 0.796442688 0.714028314 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway RNA degradation 0.526956522 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway RNA polymerase 0 -0.567193676 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Roseburia -0.408695652 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no Neurotrophin signaling pathway Sarcina 0 0.466781936 0 kegg Genus NA 0.0703 no no no no no no Neurotrophin signaling pathway Signaling pathways regulating pluripotency of stem cells 0.72 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway SNARE interactions in vesicular transport 0 0.416996047 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Sphingolipid signaling pathway 0.722608696 0.747035573 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Steroid biosynthesis 0 -0.813241107 -0.501930502 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Steroid hormone biosynthesis -0.619130435 -0.794466403 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Sulfur metabolism -0.531304348 -0.476284585 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Synthesis and degradation of ketone bodies -0.549565217 -0.788537549 -0.4996139 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway T cell receptor signaling pathway 0.593913043 0.622529644 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Terpenoid backbone biosynthesis 0 -0.524703557 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway TGF-beta signaling pathway 0.439130435 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Th1 and Th2 cell differentiation 0 0.559288538 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Th17 cell differentiation 0 0.644268775 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Thermogenesis 0.434782609 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Thiamine metabolism 0 -0.466403162 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Tight junction 0 -0.418972332 -0.436808237 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway TNF signaling pathway 0.823478261 0.896245059 0.853796654 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Toll-like receptor signaling pathway 0.613913043 0.835968379 0.74954955 yes kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Tryptophan metabolism -0.783478261 -0.685770751 -0.44041184 kegg kegg NA NA no no no no up no Neurotrophin signaling pathway Tyrosine metabolism -0.827826087 -0.871541502 -0.796138996 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.715652174 -0.805335968 -0.505534106 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway "Valine, leucine and isoleucine degradation" -0.707826087 -0.779644269 -0.631660232 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Vascular smooth muscle contraction 0 -0.516798419 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway VEGF signaling pathway 0.713913043 0.646245059 0.586100386 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Viral protein interaction with cytokine and cytokine receptor 0.420869565 0 0 kegg kegg NA NA no no no no no no Neurotrophin signaling pathway Wnt signaling pathway 0.46173913 -0.43972332 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation 2-Oxocarboxylic acid metabolism 0 -0.539525692 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Adherens junction 0.424347826 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Adrenergic signaling in cardiomyocytes -0.47826087 -0.643280632 -0.544401544 kegg kegg NA NA no no no no no up Neutrophil extracellular trap formation "Alanine, aspartate and glutamate metabolism" 0.486956522 0.566205534 0.516602317 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation alpha-Linolenic acid metabolism 0.48 0.509881423 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Aminoacyl-tRNA biosynthesis 0 -0.565217391 -0.436293436 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation AMPK signaling pathway 0 -0.654150198 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Anaerostipes 0 -0.436139493 0 butyrate-producing kegg Genus NA 0.568 no no no no no no Neutrophil extracellular trap formation Antifolate resistance 0 -0.47826087 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Antigen processing and presentation 0.444347826 0 0.543886744 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Apelin signaling pathway -0.616521739 -0.561264822 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Apoptosis 0.766956522 0.666007905 0.769369369 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Apoptosis - multiple species -0.467826087 0 -0.476705277 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Arginine and proline metabolism 0.595652174 0.630434783 0.484942085 kegg kegg NA NA no no no no up no Neutrophil extracellular trap formation Arginine biosynthesis 0.622608696 0.626482213 0.616731017 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Autophagy - other -0.505217391 0 -0.662290862 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Basal transcription factors -0.666086957 -0.706521739 -0.763963964 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Base excision repair -0.55826087 -0.638339921 -0.583011583 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Biosynthesis of amino acids 0.689565217 0.847826087 0.847104247 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Biosynthesis of cofactors 0 -0.602766798 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Butanoate metabolism 0 -0.460474308 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Calcium signaling pathway -0.496521739 -0.462450593 -0.52972973 kegg kegg NA NA no no no no up up Neutrophil extracellular trap formation Carbon metabolism 0.47826087 0.503952569 0.736164736 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Cardiac muscle contraction -0.414782609 -0.507905138 0 kegg kegg NA NA no no no no no up Neutrophil extracellular trap formation Cell adhesion molecules 0.515652174 0.654150198 0.497554698 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Cell cycle -0.592173913 -0.803359684 -0.796911197 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Cellular senescence 0.484347826 0.621541502 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation cGMP-PKG signaling pathway 0 0.878458498 0.447361647 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Chemokine signaling pathway 0 0.701581028 0.564736165 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Citrate cycle (TCA cycle) 0 -0.445652174 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Complement and coagulation cascades 0.706086957 0.896245059 0.793050193 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Cysteine and methionine metabolism 0 -0.451581028 -0.425740026 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Cytokine-cytokine receptor interaction 0 0.572134387 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation DNA replication -0.486086957 -0.635375494 -0.585070785 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Drug metabolism - cytochrome P450 0 -0.5 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation ECM-receptor interaction -0.462608696 0 -0.481338481 kegg kegg NA NA no no no no up up Neutrophil extracellular trap formation EGFR tyrosine kinase inhibitor resistance -0.616521739 -0.564229249 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Endocrine resistance -0.560869565 -0.463438735 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Endocytosis 0.656521739 0.706521739 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Ether lipid metabolism -0.489565217 -0.605731225 -0.521235521 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Fanconi anemia pathway -0.465217391 -0.625494071 -0.663320463 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Fatty acid biosynthesis 0.546956522 0.658102767 0.408751609 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Fatty acid degradation 0.483478261 0.455533597 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Fatty acid metabolism 0.575652174 0.584980237 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Folate biosynthesis 0 -0.543478261 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Galactose metabolism 0.525217391 0.468379447 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Glutathione metabolism 0 -0.542490119 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Glycerolipid metabolism 0 0 -0.447619048 kegg kegg NA NA no no no no no up Neutrophil extracellular trap formation Glycerophospholipid metabolism 0 0 -0.595366795 kegg kegg NA NA no no no no no up Neutrophil extracellular trap formation "Glycine, serine and threonine metabolism" 0 -0.5 0 kegg kegg NA NA no no no no up no Neutrophil extracellular trap formation Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.611304348 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.424901186 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Glycosaminoglycan biosynthesis - keratan sulfate -0.430434783 -0.451581028 -0.557528958 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Glycosaminoglycan degradation 0.610434783 0.603754941 0 kegg kegg NA NA no no no no no up Neutrophil extracellular trap formation Glycosphingolipid biosynthesis - ganglio series 0 -0.509881423 -0.401287001 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 -0.422651223 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.531620553 -0.501673102 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Glyoxylate and dicarboxylate metabolism 0.56173913 0.648221344 0.633976834 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Hedgehog signaling pathway -0.440869565 -0.665019763 -0.732046332 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation HIF-1 signaling pathway -0.516521739 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Hippo signaling pathway - multiple species 0 0.446640316 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Homologous recombination 0 -0.484189723 -0.656628057 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Inositol phosphate metabolism 0 0 -0.527413127 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Lysine degradation -0.566086957 -0.717391304 -0.763449163 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Lysosome 0.759130435 0.860671937 0.741827542 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Mannose type O-glycan biosynthesis -0.44 -0.638339921 -0.728185328 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Mismatch repair 0 -0.448616601 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Mitophagy - animal -0.54173913 -0.54743083 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation mRNA surveillance pathway -0.668695652 -0.865612648 -0.848648649 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation mTOR signaling pathway -0.62173913 -0.56916996 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation N-Glycan biosynthesis -0.669565217 -0.749011858 -0.665894466 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Neuroactive ligand-receptor interaction 0.664347826 0.897233202 0.818532819 kegg kegg NA NA no no no up up up Neutrophil extracellular trap formation Nicotinate and nicotinamide metabolism 0.705217391 0.764822134 0.667438867 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Nitrogen metabolism 0.64 0.595849802 0.488288288 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Notch signaling pathway 0 0 -0.422908623 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Nucleotide excision repair -0.453043478 -0.604743083 -0.54028314 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation One carbon pool by folate -0.427826087 -0.588932806 -0.622393822 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Oocyte meiosis -0.553913043 0 -0.516087516 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Osteoclast differentiation 0.816521739 0.793478261 0.718404118 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Other types of O-glycan biosynthesis -0.607826087 -0.661067194 -0.763963964 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Oxidative phosphorylation -0.433043478 -0.48715415 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation p53 signaling pathway -0.569565217 -0.420948617 -0.675160875 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Pantothenate and CoA biosynthesis 0.677391304 0.753952569 0.557528958 kegg kegg NA NA no no no no no dn Neutrophil extracellular trap formation Pentose and glucuronate interconversions 0 -0.625494071 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Pentose phosphate pathway 0.831304348 0.955533597 0.796396396 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Peroxisome 0.586956522 0.66798419 0.585585586 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Phagosome 0.725217391 0.81916996 0.758815959 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Phosphatidylinositol signaling system -0.584347826 -0.427865613 -0.731531532 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Phospholipase D signaling pathway 0 0.414031621 0 kegg kegg NA NA no no no no up up Neutrophil extracellular trap formation PI3K-Akt signaling pathway 0 0 -0.417760618 yes kegg kegg NA NA no no no no up up Neutrophil extracellular trap formation Platelet activation 0 0 0.482368082 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Platinum drug resistance -0.465217391 0 -0.57039897 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Porphyrin and chlorophyll metabolism 0 -0.498023715 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation PPAR signaling pathway 0 0.605731225 0.59047619 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Protein export -0.810434783 -0.559288538 -0.564993565 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Protein processing in endoplasmic reticulum -0.659130435 -0.847826087 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Purine metabolism 0 -0.601778656 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Pyrimidine metabolism 0 -0.427865613 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Pyruvate metabolism 0 -0.546442688 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Rap1 signaling pathway 0.492173913 0 0.554182754 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Ras signaling pathway 0 0 -0.557528958 yes kegg kegg NA NA no no no no up up Neutrophil extracellular trap formation Ribosome -0.76 -0.516798419 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Ribosome biogenesis in eukaryotes -0.737391304 -0.756916996 -0.788416988 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation RNA degradation -0.673043478 -0.828063241 -0.782496782 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation RNA polymerase -0.79826087 -0.85770751 -0.66048906 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation RNA transport 0 -0.526679842 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Ruminococcus -0.615652174 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Neutrophil extracellular trap formation Selenocompound metabolism -0.492173913 -0.479249012 -0.579150579 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Signaling pathways regulating pluripotency of stem cells -0.468695652 -0.501976285 -0.675160875 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Slackia 0 0 -0.413897497 kegg Genus NA 0.94 no no no no no no Neutrophil extracellular trap formation Sphingolipid metabolism 0.586956522 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Sphingolipid signaling pathway 0 0.538537549 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Spliceosome -0.615652174 -0.565217391 -0.752638353 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Starch and sucrose metabolism 0.751304348 0.66798419 0.404375804 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Steroid biosynthesis -0.608695652 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Synthesis and degradation of ketone bodies 0 -0.48715415 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Taurine and hypotaurine metabolism 0 0 -0.507593308 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Terpenoid backbone biosynthesis -0.494782609 0 -0.546975547 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation TGF-beta signaling pathway -0.472173913 -0.432806324 -0.475418275 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Thiamine metabolism 0 -0.484189723 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Tight junction 0.411304348 0 0.605662806 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.420948617 -0.478249678 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Ubiquitin mediated proteolysis -0.655652174 -0.670948617 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation "Valine, leucine and isoleucine degradation" 0 -0.4743083 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Various types of N-glycan biosynthesis -0.580869565 -0.656126482 -0.525868726 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Vascular smooth muscle contraction -0.451304348 0 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Viral protein interaction with cytokine and cytokine receptor 0 0.632411067 0 kegg kegg NA NA no no no no no no Neutrophil extracellular trap formation Wnt signaling pathway 0 -0.756916996 -0.670527671 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway 2-Oxocarboxylic acid metabolism 0 -0.542490119 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway ABC transporters 0.623478261 0.482213439 0 kegg kegg NA NA no no no no up up NF-kappa B signaling pathway "Alanine, aspartate and glutamate metabolism" 0.551304348 0.791501976 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway alpha-Linolenic acid metabolism 0 0.531620553 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Arachidonic acid metabolism -0.522608696 0 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Arginine and proline metabolism 0 0.795454545 0.427799228 kegg kegg NA NA no no no no up no NF-kappa B signaling pathway Arginine biosynthesis 0.495652174 0.739130435 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway beta-Alanine metabolism 0 -0.490118577 -0.570913771 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Biosynthesis of amino acids 0 0.429841897 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Biosynthesis of cofactors -0.451304348 -0.457509881 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Biosynthesis of unsaturated fatty acids 0 -0.425889328 -0.654311454 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Butanoate metabolism 0 -0.756916996 -0.55984556 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway cAMP signaling pathway 0 0.54743083 0.463320463 yes kegg kegg NA NA no no no no up up NF-kappa B signaling pathway cGMP-PKG signaling pathway 0 0.507905138 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Chemokine signaling pathway 0 0.538537549 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Citrate cycle (TCA cycle) 0 -0.759881423 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Collinsella 0 0 -0.404741474 kegg Genus NA 0.128 no no no no no no NF-kappa B signaling pathway Cysteine and methionine metabolism 0 -0.812252964 -0.402059202 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Cytokine-cytokine receptor interaction 0 0 -0.512998713 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway DNA replication 0 -0.713438735 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Drug metabolism - cytochrome P450 0 -0.803359684 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Drug metabolism - other enzymes 0 -0.846837945 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.646245059 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway ErbB signaling pathway 0.502608696 0.606719368 0.402831403 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Fatty acid biosynthesis 0.473913043 0.738142292 0.477477477 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Fatty acid degradation 0.411304348 0.53458498 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Fatty acid elongation 0 -0.533596838 -0.602316602 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Fructose and mannose metabolism 0 0.581027668 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Galactose metabolism 0 0.533596838 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Glutathione metabolism -0.612173913 -0.661067194 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Glycerolipid metabolism 0.729565217 0.59486166 0 kegg kegg NA NA no no no no no up NF-kappa B signaling pathway Glycerophospholipid metabolism 0.500869565 0.519762846 0 kegg kegg NA NA no no no no no up NF-kappa B signaling pathway "Glycine, serine and threonine metabolism" -0.535652174 0 0 kegg kegg NA NA no no no no up no NF-kappa B signaling pathway Glycolysis / Gluconeogenesis 0 -0.766798419 -0.452252252 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.473913043 0.898221344 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Glycosphingolipid biosynthesis - globo and isoglobo series -0.56 0 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.558300395 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Glyoxylate and dicarboxylate metabolism 0.537391304 0.72826087 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Inositol phosphate metabolism 0.56173913 0.454545455 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Lachnospira 0 -0.51791452 0 butyrate-producing kegg Genus NA 0.279 no no no no no no NF-kappa B signaling pathway Lysine degradation 0.457391304 0 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.808300395 -0.427799228 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Mismatch repair 0 -0.669960474 -0.542857143 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway N-Glycan biosynthesis 0 -0.665019763 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Nicotinate and nicotinamide metabolism 0.450434783 0.736166008 0.462033462 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Nitrogen metabolism 0 0.693675889 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Non-homologous end-joining 0 -0.651185771 -0.489060489 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Nucleotide excision repair 0 -0.627470356 -0.472329472 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway One carbon pool by folate 0 -0.638339921 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Oscillospira 0 0.433794466 0 LPS-producing kegg Genus NA 0.62 no no no no no no NF-kappa B signaling pathway Other glycan degradation 0.482608696 0.568181818 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Oxidative phosphorylation 0 -0.723320158 -0.422136422 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Pantothenate and CoA biosynthesis 0.525217391 0.621541502 0 kegg kegg NA NA no no no no no dn NF-kappa B signaling pathway Pentose and glucuronate interconversions 0 -0.73715415 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Phenylalanine metabolism 0 -0.704545455 -0.503732304 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Platinum drug resistance 0.448695652 0 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Porphyrin and chlorophyll metabolism -0.533043478 0 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway PPAR signaling pathway 0 0.688735178 0.407722008 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Primary bile acid biosynthesis 0 -0.586956522 -0.501415701 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Propanoate metabolism 0 -0.783596838 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Proteasome 0 -0.714426877 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Protein export 0 -0.751976285 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Pyrimidine metabolism 0 -0.650197628 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Pyruvate metabolism 0 -0.833992095 -0.427541828 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Rap1 signaling pathway -0.408695652 -0.475296443 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Ras signaling pathway 0 -0.684782609 0 yes kegg kegg NA NA no no no no up up NF-kappa B signaling pathway Retinol metabolism 0 -0.489130435 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Ribosome 0 -0.743083004 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Ribosome biogenesis in eukaryotes 0 -0.460474308 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway RNA degradation 0 -0.615612648 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway RNA polymerase 0 -0.578063241 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway RNA transport 0 -0.591897233 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Roseburia -0.450434783 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no NF-kappa B signaling pathway Sarcina 0 0.422326513 0 kegg Genus NA 0.0703 no no no no no no NF-kappa B signaling pathway Selenocompound metabolism 0.429565217 0 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Starch and sucrose metabolism 0 0.647233202 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Steroid biosynthesis 0 -0.661067194 -0.57014157 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Steroid hormone biosynthesis 0 -0.613636364 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Synthesis and degradation of ketone bodies 0 -0.562252964 -0.472329472 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Taurine and hypotaurine metabolism 0.545217391 0.658102767 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Thiamine metabolism 0 -0.600790514 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Tryptophan metabolism 0 -0.625494071 0 kegg kegg NA NA no no no no up no NF-kappa B signaling pathway Tyrosine metabolism 0 -0.789525692 -0.708622909 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.549407115 -0.445559846 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway "Valine, leucine and isoleucine degradation" 0 -0.669960474 -0.545688546 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Various types of N-glycan biosynthesis 0 -0.488142292 0 kegg kegg NA NA no no no no no no NF-kappa B signaling pathway Viral protein interaction with cytokine and cytokine receptor 0 0 -0.434749035 kegg kegg NA NA no no no no no no Nicotinamide+urine 2-hydroxyphenylacetic acid+urine 0.57593985 0.58245614 0.490598291 urine_cometabolism urine_cometabolism 0.721 0.763 no no no no no no Nicotinamide+urine 4-hydroxybenzoic acid+urine 0 0.59122807 0 urine_cometabolism urine_cometabolism 0.721 0.52 no no no no no no Nicotinamide+urine Homovanillic acid+urine 0 0.607017544 0.557606838 urine_cometabolism urine_cometabolism 0.721 0.45 no no no no no no Nicotinamide+urine Kynurenic acid+urine 0 -0.559649123 0 urine_cometabolism urine_cometabolism 0.721 0.296 no no no no no no Nicotinate and nicotinamide metabolism "Alanine, aspartate and glutamate metabolism" 0.828695652 0.90513834 0.723294723 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism alpha-Linolenic acid metabolism 0 0.650197628 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Arginine and proline metabolism 0.793913043 0.859683794 0.755984556 kegg kegg NA NA no no no no up no Nicotinate and nicotinamide metabolism Arginine biosynthesis 0.87826087 0.89229249 0.763706564 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Ascorbate and aldarate metabolism 0 -0.421936759 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Butanoate metabolism 0 -0.745059289 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Citrate cycle (TCA cycle) 0 -0.740118577 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Cysteine and methionine metabolism 0 -0.711462451 -0.536936937 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Ether lipid metabolism -0.51826087 -0.592885375 -0.43963964 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Fatty acid biosynthesis 0.903478261 0.93972332 0.772200772 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Fatty acid degradation 0.740869565 0.697628458 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Galactose metabolism 0 0.624505929 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Glutathione metabolism 0 -0.654150198 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism "Glycine, serine and threonine metabolism" -0.493043478 -0.436758893 0 kegg kegg NA NA no no no no up no Nicotinate and nicotinamide metabolism Glycolysis / Gluconeogenesis 0 -0.549407115 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.760869565 0.752964427 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.56916996 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.491304348 -0.468379447 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Glycosaminoglycan degradation 0 0.5 0 kegg kegg NA NA no no no no no up Nicotinate and nicotinamide metabolism Glycosphingolipid biosynthesis - ganglio series 0 -0.5 -0.441441441 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Glyoxylate and dicarboxylate metabolism 0.800869565 0.898221344 0.833204633 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Lysine degradation 0 0 -0.458172458 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Mannose type O-glycan biosynthesis 0 0 -0.447619048 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism N-Glycan biosynthesis -0.513043478 -0.890316206 -0.6002574 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism One carbon pool by folate 0 -0.65513834 -0.619047619 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Other types of O-glycan biosynthesis 0 0 -0.448133848 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Oxidative phosphorylation 0 -0.726284585 -0.475418275 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Paraprevotella 0 -0.498195609 0 kegg Genus NA 0.118 no no no no no no Nicotinate and nicotinamide metabolism Pentose and glucuronate interconversions 0 -0.872529644 -0.522007722 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Pentose phosphate pathway 0.486956522 0.756916996 0.819047619 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Phenylalanine metabolism 0 -0.592885375 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Prevotella 0 0.450312019 0 acetate-producing kegg Genus NA 0.287 no no no no no no Nicotinate and nicotinamide metabolism Propanoate metabolism 0 -0.638339921 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Purine metabolism 0 -0.516798419 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Pyrimidine metabolism 0 -0.651185771 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Pyruvate metabolism 0 -0.77173913 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Starch and sucrose metabolism 0.662608696 0.882411067 0.501415701 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Steroid biosynthesis -0.429565217 -0.415019763 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Synthesis and degradation of ketone bodies 0 -0.543478261 -0.415958816 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Thiamine metabolism 0 -0.641304348 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Tyrosine metabolism 0 -0.572134387 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.523715415 -0.416216216 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism "Valine, leucine and isoleucine degradation" 0 -0.660079051 0 kegg kegg NA NA no no no no no no Nicotinate and nicotinamide metabolism Various types of N-glycan biosynthesis 0 -0.787549407 -0.401801802 kegg kegg NA NA no no no no no no Nicotine addiction ABC transporters 0 0.809288538 0 kegg kegg NA NA no up up no up up Nicotine addiction Antifolate resistance 0 0.566205534 0 kegg kegg NA NA no up up no no no Nicotine addiction Antigen processing and presentation 0 -0.686758893 0 kegg kegg NA NA no up up no no no Nicotine addiction Apelin signaling pathway -0.433043478 0 0 kegg kegg NA NA no up up no no no Nicotine addiction Apoptosis - multiple species 0 0.588932806 0 kegg kegg NA NA no up up no no no Nicotine addiction Autophagy - other 0 0.444664032 0 kegg kegg NA NA no up up no no no Nicotine addiction B cell receptor signaling pathway 0.460869565 0 0.577091377 kegg kegg NA NA no up up no no no Nicotine addiction Base excision repair 0 0.531620553 -0.413384813 kegg kegg NA NA no up up no no no Nicotine addiction beta-Alanine metabolism 0 0 -0.584041184 kegg kegg NA NA no up up no no no Nicotine addiction Biosynthesis of unsaturated fatty acids 0 0 -0.596653797 kegg kegg NA NA no up up no no no Nicotine addiction Butanoate metabolism 0 0 -0.585328185 kegg kegg NA NA no up up no no no Nicotine addiction C-type lectin receptor signaling pathway 0 0 0.492406692 kegg kegg NA NA no up up no no no Nicotine addiction cAMP signaling pathway 0 0 0.434234234 yes kegg kegg NA NA no up up no up up Nicotine addiction Carbohydrate digestion and absorption 0 0.544466403 0 kegg kegg NA NA no up up no no no Nicotine addiction Carbon metabolism 0 -0.566205534 0 kegg kegg NA NA no up up no no no Nicotine addiction Cell cycle 0 0.503952569 0 kegg kegg NA NA no up up no no no Nicotine addiction Cholesterol metabolism 0 -0.567193676 0 yes kegg kegg NA NA no up up no no up Nicotine addiction Circadian rhythm 0 0.580039526 0 kegg kegg NA NA no up up no no no Nicotine addiction Collecting duct acid secretion 0 -0.424901186 0 kegg kegg NA NA no up up no no no Nicotine addiction Cortisol synthesis and secretion 0 0.448616601 0 kegg kegg NA NA no up up no no up Nicotine addiction Cushing syndrome 0 0.518774704 0 kegg kegg NA NA no up up no no up Nicotine addiction Cysteine and methionine metabolism -0.46 0 -0.541312741 kegg kegg NA NA no up up no no no Nicotine addiction Cytosolic DNA-sensing pathway 0 0 0.507593308 kegg kegg NA NA no up up no no no Nicotine addiction Drug metabolism - cytochrome P450 -0.482608696 0 0 kegg kegg NA NA no up up no no no Nicotine addiction Endocrine resistance 0 0.476284585 0 kegg kegg NA NA no up up no no no Nicotine addiction ErbB signaling pathway 0 0.611660079 0 kegg kegg NA NA no up up no no no Nicotine addiction Estrogen signaling pathway 0 0 -0.645559846 kegg kegg NA NA no up up no no no Nicotine addiction Fanconi anemia pathway 0 0.609683794 0 kegg kegg NA NA no up up no no no Nicotine addiction Fatty acid elongation 0 -0.479249012 -0.728185328 kegg kegg NA NA no up up no no no Nicotine addiction Focal adhesion 0 -0.459486166 0 kegg kegg NA NA no up up no up up Nicotine addiction FoxO signaling pathway 0 0.455533597 0 kegg kegg NA NA no up up no no no Nicotine addiction Glycerolipid metabolism 0 0.71541502 0 kegg kegg NA NA no up up no no up Nicotine addiction Glycerophospholipid metabolism 0 0.723320158 0 kegg kegg NA NA no up up no no up Nicotine addiction Glycolysis / Gluconeogenesis 0 0 -0.458687259 kegg kegg NA NA no up up no no no Nicotine addiction Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.40952381 kegg kegg NA NA no up up no no no Nicotine addiction Glycosaminoglycan degradation 0 -0.451581028 0 kegg kegg NA NA no up up no no up Nicotine addiction Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 0.495238095 kegg kegg NA NA no up up no no no Nicotine addiction Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.625494071 0 kegg kegg NA NA no up up no no no Nicotine addiction GnRH secretion 0 0.652173913 0 kegg kegg NA NA no up up no up up Nicotine addiction "Growth hormone synthesis, secretion and action" 0 0.510869565 0 kegg kegg NA NA no up up no no no Nicotine addiction Hedgehog signaling pathway 0 0.627470356 0 kegg kegg NA NA no up up no no no Nicotine addiction Hematopoietic cell lineage 0 0 -0.497297297 kegg kegg NA NA no up up no no no Nicotine addiction Homologous recombination 0 0.691699605 0 kegg kegg NA NA no up up no no no Nicotine addiction IL-17 signaling pathway 0 -0.419960474 0 kegg kegg NA NA no up up no no no Nicotine addiction Inositol phosphate metabolism 0 0.683794466 0 kegg kegg NA NA no up up no no no Nicotine addiction Insulin resistance 0 0 0.475675676 kegg kegg NA NA no up up no no no Nicotine addiction Insulin signaling pathway -0.435652174 0 0 kegg kegg NA NA no up up no no no Nicotine addiction JAK-STAT signaling pathway 0 0.442687747 0 kegg kegg NA NA no up up no no no Nicotine addiction Leukocyte transendothelial migration 0 -0.659090909 0 kegg kegg NA NA no up up no no no Nicotine addiction Linoleic acid metabolism -0.491304348 0 0 kegg kegg NA NA no up up no no no Nicotine addiction Longevity regulating pathway - multiple species 0 0 -0.604118404 kegg kegg NA NA no up up no no no Nicotine addiction Lysine degradation 0 0.725296443 0 kegg kegg NA NA no up up no no no Nicotine addiction Lysosome 0 -0.626482213 0 kegg kegg NA NA no up up no no no Nicotine addiction Mannose type O-glycan biosynthesis 0 0.639328063 0 kegg kegg NA NA no up up no no no Nicotine addiction MAPK signaling pathway 0 0.453557312 0 kegg kegg NA NA no up up no no no Nicotine addiction Metabolism of xenobiotics by cytochrome P450 -0.496521739 0 0 kegg kegg NA NA no up up no no no Nicotine addiction Mismatch repair 0 0 -0.526898327 kegg kegg NA NA no up up no no no Nicotine addiction Mucin type O-glycan biosynthesis -0.408695652 0 0 kegg kegg NA NA no up up no no no Nicotine addiction Neuroactive ligand-receptor interaction 0 -0.5 0 kegg kegg NA NA no up up up up up Nicotine addiction Neurotrophin signaling pathway 0 0 0.583526384 kegg kegg NA NA no up up no no no Nicotine addiction NF-kappa B signaling pathway 0.429565217 0 0.413899614 kegg kegg NA NA no up up no no no Nicotine addiction Non-homologous end-joining 0 0 -0.607722008 kegg kegg NA NA no up up no no no Nicotine addiction Notch signaling pathway 0 0.483201581 0 kegg kegg NA NA no up up no no no Nicotine addiction Nucleotide excision repair 0 0 -0.473616474 kegg kegg NA NA no up up no no no Nicotine addiction Oocyte meiosis -0.548695652 0 0 kegg kegg NA NA no up up no no no Nicotine addiction Other glycan degradation 0 0.524703557 0 kegg kegg NA NA no up up no no no Nicotine addiction Other types of O-glycan biosynthesis 0 0.83201581 0 kegg kegg NA NA no up up no no no Nicotine addiction Oxytocin signaling pathway 0 -0.526679842 0 kegg kegg NA NA no up up no no no Nicotine addiction p53 signaling pathway 0 0.666996047 0 kegg kegg NA NA no up up no no no Nicotine addiction Pentose and glucuronate interconversions -0.425217391 0 0 kegg kegg NA NA no up up no no no Nicotine addiction Pentose phosphate pathway 0 -0.41798419 0 kegg kegg NA NA no up up no no no Nicotine addiction Phagosome 0 -0.421936759 0 kegg kegg NA NA no up up no no no Nicotine addiction Phosphatidylinositol signaling system 0 0.52173913 0 kegg kegg NA NA no up up no no no Nicotine addiction Phototransduction -0.565217391 -0.579051383 0 kegg kegg NA NA no up up no no no Nicotine addiction Platelet activation 0 -0.445652174 0 kegg kegg NA NA no up up no no no Nicotine addiction Platinum drug resistance 0 0.693675889 0 kegg kegg NA NA no up up no no no Nicotine addiction Primary bile acid biosynthesis 0 0 -0.568339768 kegg kegg NA NA no up up no no no Nicotine addiction Progesterone-mediated oocyte maturation 0 0.7756917 0 kegg kegg NA NA no up up no no no Nicotine addiction Propanoate metabolism -0.411304348 0 -0.572972973 kegg kegg NA NA no up up no no no Nicotine addiction Proximal tubule bicarbonate reclamation -0.42 0 -0.448133848 kegg kegg NA NA no up up no no no Nicotine addiction Pyruvate metabolism -0.428695652 0 -0.572458172 kegg kegg NA NA no up up no no no Nicotine addiction Ras signaling pathway -0.452173913 0 0 yes kegg kegg NA NA no up up no up up Nicotine addiction Regulation of actin cytoskeleton 0 -0.592885375 -0.480566281 kegg kegg NA NA no up up no no no Nicotine addiction Relaxin signaling pathway 0 0 0.486486486 kegg kegg NA NA no up up no no no Nicotine addiction Renin secretion -0.406086957 0 0 kegg kegg NA NA no up up no no no Nicotine addiction Renin-angiotensin system 0 -0.467391304 0 kegg kegg NA NA no up up no no no Nicotine addiction Ribosome biogenesis in eukaryotes 0 0.511857708 0 kegg kegg NA NA no up up no no no Nicotine addiction RIG-I-like receptor signaling pathway 0 0 0.475418275 kegg kegg NA NA no up up no no no Nicotine addiction Selenocompound metabolism 0 0.664031621 0 kegg kegg NA NA no up up no no no Nicotine addiction Signaling pathways regulating pluripotency of stem cells 0 0.615612648 0 kegg kegg NA NA no up up no no no Nicotine addiction Spinocerebellar ataxia 0 0.52173913 0 kegg kegg NA NA no up up no no no Nicotine addiction Spliceosome 0 0.722332016 0 kegg kegg NA NA no up up no no no Nicotine addiction Steroid biosynthesis 0 0 -0.457142857 kegg kegg NA NA no up up no no no Nicotine addiction Synthesis and degradation of ketone bodies 0 0 -0.498841699 kegg kegg NA NA no up up no no no Nicotine addiction T cell receptor signaling pathway 0 0.472332016 0 kegg kegg NA NA no up up no no no Nicotine addiction Taurine and hypotaurine metabolism 0 0.748023715 0 kegg kegg NA NA no up up no no no Nicotine addiction Tight junction 0 -0.557312253 0 kegg kegg NA NA no up up no no no Nicotine addiction TNF signaling pathway 0 0 0.662033462 kegg kegg NA NA no up up no no no Nicotine addiction Toll-like receptor signaling pathway 0 0 0.541055341 yes kegg kegg NA NA no up up no no no Nicotine addiction Tryptophan metabolism 0 0 -0.471299871 kegg kegg NA NA no up up no up no Nicotine addiction Type II diabetes mellitus 0 0.451581028 0 kegg kegg NA NA no up up no no no Nicotine addiction Tyrosine metabolism 0 0 -0.546460746 kegg kegg NA NA no up up no no no Nicotine addiction "Valine, leucine and isoleucine degradation" 0 0 -0.594337194 kegg kegg NA NA no up up no no no Nicotine addiction Viral protein interaction with cytokine and cytokine receptor 0 -0.468379447 0 kegg kegg NA NA no up up no no no Nitrogen metabolism "Alanine, aspartate and glutamate metabolism" 0.825217391 0.915019763 0.857400257 kegg kegg NA NA no no no no no no Nitrogen metabolism alpha-Linolenic acid metabolism 0 0.510869565 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Arachidonic acid metabolism 0 0 0.402831403 kegg kegg NA NA no no no no no no Nitrogen metabolism Arginine and proline metabolism 0.684347826 0.850790514 0.650965251 kegg kegg NA NA no no no no up no Nitrogen metabolism Arginine biosynthesis 0.869565217 0.947628458 0.914285714 kegg kegg NA NA no no no no no no Nitrogen metabolism Ascorbate and aldarate metabolism 0 -0.619565217 -0.48957529 kegg kegg NA NA no no no no no no Nitrogen metabolism Butanoate metabolism 0 -0.734189723 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Citrate cycle (TCA cycle) -0.41826087 -0.71541502 -0.518404118 kegg kegg NA NA no no no no no no Nitrogen metabolism Cysteine and methionine metabolism 0 -0.62055336 -0.487516088 kegg kegg NA NA no no no no no no Nitrogen metabolism Ether lipid metabolism -0.533043478 -0.570158103 -0.510682111 kegg kegg NA NA no no no no no no Nitrogen metabolism Fatty acid biosynthesis 0.751304348 0.846837945 0.63011583 kegg kegg NA NA no no no no no no Nitrogen metabolism Fatty acid degradation 0.492173913 0.592885375 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Folate biosynthesis 0 -0.776679842 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Glycerolipid metabolism 0 0 -0.537451737 kegg kegg NA NA no no no no no up Nitrogen metabolism Glycerophospholipid metabolism 0 0 -0.508880309 kegg kegg NA NA no no no no no up Nitrogen metabolism "Glycine, serine and threonine metabolism" 0 0 0.446332046 kegg kegg NA NA no no no no up no Nitrogen metabolism Glycolysis / Gluconeogenesis 0 -0.500988142 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.78173913 0.62944664 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.710474308 -0.654568855 kegg kegg NA NA no no no no no no Nitrogen metabolism Glycosaminoglycan biosynthesis - keratan sulfate 0 -0.533596838 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Glycosphingolipid biosynthesis - ganglio series 0 -0.541501976 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Glyoxylate and dicarboxylate metabolism 0.784347826 0.948616601 0.858687259 kegg kegg NA NA no no no no no no Nitrogen metabolism Inositol phosphate metabolism 0 0 -0.49034749 kegg kegg NA NA no no no no no no Nitrogen metabolism Lysine degradation 0 0 -0.656628057 kegg kegg NA NA no no no no no no Nitrogen metabolism Mannose type O-glycan biosynthesis 0 -0.442687747 -0.651222651 kegg kegg NA NA no no no no no no Nitrogen metabolism N-Glycan biosynthesis -0.575652174 -0.885375494 -0.656885457 kegg kegg NA NA no no no no no no Nitrogen metabolism Nicotinate and nicotinamide metabolism 0.774782609 0.838932806 0.682882883 kegg kegg NA NA no no no no no no Nitrogen metabolism One carbon pool by folate -0.565217391 -0.693675889 -0.748262548 kegg kegg NA NA no no no no no no Nitrogen metabolism Other glycan degradation 0 0 -0.513256113 kegg kegg NA NA no no no no no no Nitrogen metabolism Other types of O-glycan biosynthesis 0 0 -0.523552124 kegg kegg NA NA no no no no no no Nitrogen metabolism Oxidative phosphorylation -0.467826087 -0.624505929 -0.443243243 kegg kegg NA NA no no no no no no Nitrogen metabolism Pantothenate and CoA biosynthesis 0.559130435 0.706521739 0.485714286 kegg kegg NA NA no no no no no dn Nitrogen metabolism Pentose and glucuronate interconversions -0.453913043 -0.868577075 -0.71016731 kegg kegg NA NA no no no no no no Nitrogen metabolism Pentose phosphate pathway 0.611304348 0.580039526 0.617245817 kegg kegg NA NA no no no no no no Nitrogen metabolism Phenylalanine metabolism 0 -0.706521739 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Porphyrin and chlorophyll metabolism 0 0 0.438352638 kegg kegg NA NA no no no no no no Nitrogen metabolism Propanoate metabolism 0 -0.539525692 -0.403861004 kegg kegg NA NA no no no no no no Nitrogen metabolism Pyrimidine metabolism 0 -0.609683794 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Pyruvate metabolism 0 -0.640316206 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Retinol metabolism 0 0 -0.437580438 kegg kegg NA NA no no no no no no Nitrogen metabolism Selenocompound metabolism 0 0 -0.458687259 kegg kegg NA NA no no no no no no Nitrogen metabolism Starch and sucrose metabolism 0.615652174 0.687747036 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Steroid biosynthesis -0.606956522 -0.43083004 -0.44967825 kegg kegg NA NA no no no no no no Nitrogen metabolism Steroid hormone biosynthesis 0 -0.469367589 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Synthesis and degradation of ketone bodies 0 -0.498023715 -0.484427284 kegg kegg NA NA no no no no no no Nitrogen metabolism Terpenoid backbone biosynthesis -0.484347826 0 -0.424453024 kegg kegg NA NA no no no no no no Nitrogen metabolism Thiamine metabolism 0 -0.416996047 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Tryptophan metabolism 0 -0.530632411 0 kegg kegg NA NA no no no no up no Nitrogen metabolism Tyrosine metabolism 0 -0.571146245 0 kegg kegg NA NA no no no no no no Nitrogen metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.570158103 -0.490862291 kegg kegg NA NA no no no no no no Nitrogen metabolism "Valine, leucine and isoleucine degradation" 0 -0.7243083 -0.507078507 kegg kegg NA NA no no no no no no Nitrogen metabolism Various types of N-glycan biosynthesis 0 -0.766798419 -0.599227799 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway 2-Oxocarboxylic acid metabolism 0 -0.516798419 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Adherens junction 0 -0.690711462 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Adrenergic signaling in cardiomyocytes 0 -0.663043478 -0.407722008 kegg kegg NA NA no no no no no up NOD-like receptor signaling pathway "Alanine, aspartate and glutamate metabolism" 0.684347826 0.788537549 0.562676963 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Alistipes -0.440178869 0 0 kegg Genus NA 0.0114 no no no no up no NOD-like receptor signaling pathway alpha-Linolenic acid metabolism 0.446086957 0.562252964 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway AMPK signaling pathway -0.609565217 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Antifolate resistance 0 -0.437747036 -0.421621622 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Apelin signaling pathway 0 -0.684782609 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Apoptosis 0.489565217 0.807312253 0.436808237 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Arginine and proline metabolism 0.770434783 0.78458498 0 kegg kegg NA NA no no no no up no NOD-like receptor signaling pathway Arginine biosynthesis 0.713913043 0.763833992 0.534362934 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Autophagy - animal 0.505217391 0.843873518 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Autophagy - other 0 0.459486166 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Biosynthesis of amino acids 0.44 0.672924901 0.440669241 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Biosynthesis of cofactors -0.565217391 -0.589920949 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Butanoate metabolism 0 -0.623517787 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Calcium signaling pathway -0.477391304 -0.579051383 0 kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Cardiac muscle contraction 0 -0.756916996 0 kegg kegg NA NA no no no no no up NOD-like receptor signaling pathway Cell adhesion molecules 0 0.561264822 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Cell cycle 0 -0.635375494 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Cellular senescence 0 0.639328063 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway cGMP-PKG signaling pathway 0.563478261 0.699604743 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Chemokine signaling pathway 0 0.516798419 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Citrate cycle (TCA cycle) 0 -0.638339921 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Complement and coagulation cascades 0.535652174 0.562252964 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Cysteine and methionine metabolism 0 -0.616600791 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway DNA replication 0 -0.712450593 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Drug metabolism - cytochrome P450 0 -0.746047431 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Drug metabolism - other enzymes 0 -0.699604743 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway ECM-receptor interaction -0.405217391 -0.462450593 0 kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.548418972 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Endocrine resistance -0.60173913 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Endocytosis 0 0.583992095 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway ErbB signaling pathway 0 0.432806324 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Ether lipid metabolism -0.568695652 -0.52173913 -0.493436293 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Fatty acid biosynthesis 0.809565217 0.770750988 0.597425997 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Fatty acid degradation 0.7 0.664031621 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Fatty acid metabolism 0.649565217 0.600790514 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Focal adhesion 0 -0.631422925 0 kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Folate biosynthesis 0 -0.455533597 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway FoxO signaling pathway 0.545217391 0.567193676 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Fructose and mannose metabolism 0 0.489130435 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Galactose metabolism 0 0.564229249 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Gap junction -0.557391304 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Glutathione metabolism -0.474782609 -0.749011858 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway "Glycine, serine and threonine metabolism" -0.669565217 -0.493083004 0 kegg kegg NA NA no no no no up no NOD-like receptor signaling pathway Glycolysis / Gluconeogenesis 0 -0.460474308 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.608695652 0.726284585 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.425889328 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate -0.59826087 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Glycosaminoglycan degradation 0 0.459486166 0 kegg kegg NA NA no no no no no up NOD-like receptor signaling pathway Glyoxylate and dicarboxylate metabolism 0.653913043 0.796442688 0.481853282 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway HIF-1 signaling pathway 0 -0.509881423 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Hippo signaling pathway 0 -0.705533597 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Hippo signaling pathway - multiple species 0.49826087 0.704545455 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Lachnospira 0 -0.421546838 0 butyrate-producing kegg Genus NA 0.279 no no no no no no NOD-like receptor signaling pathway Linoleic acid metabolism 0 -0.41798419 -0.405920206 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Lysosome 0.520869565 0.507905138 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Mannose type O-glycan biosynthesis -0.422608696 0 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.694664032 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Mismatch repair 0 -0.597826087 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Mitophagy - animal -0.646086957 -0.496047431 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway mRNA surveillance pathway 0 -0.563241107 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway mTOR signaling pathway 0 -0.508893281 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway N-Glycan biosynthesis -0.515652174 -0.766798419 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Neuroactive ligand-receptor interaction 0.453043478 0.493083004 0 kegg kegg NA NA no no no up up up NOD-like receptor signaling pathway Neutrophil extracellular trap formation 0.649565217 0.527667984 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway NF-kappa B signaling pathway 0.517391304 0.83201581 0.448648649 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Nicotinate and nicotinamide metabolism 0.872173913 0.766798419 0.455855856 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Nitrogen metabolism 0.600869565 0.68972332 0.432947233 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Nucleotide excision repair 0 -0.651185771 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway One carbon pool by folate 0 -0.699604743 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Oocyte meiosis 0 -0.551383399 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Oscillospira 0 0 0.435521236 LPS-producing kegg Genus NA 0.62 no no no no no no NOD-like receptor signaling pathway Osteoclast differentiation 0.735652174 0.885375494 0.515057915 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Other glycan degradation 0 0.438735178 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Oxidative phosphorylation 0 -0.767786561 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Pantothenate and CoA biosynthesis 0.797391304 0.723320158 0 kegg kegg NA NA no no no no no dn NOD-like receptor signaling pathway Pentose and glucuronate interconversions 0 -0.673913043 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Pentose phosphate pathway 0.435652174 0.551383399 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Peroxisome 0.735652174 0.68083004 0.495495495 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Phagosome 0 0.523715415 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Phenylalanine metabolism 0 -0.623517787 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Phospholipase D signaling pathway 0 0.578063241 0 kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Platelet activation 0 -0.623517787 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Porphyrin and chlorophyll metabolism -0.599130435 -0.455533597 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway PPAR signaling pathway 0.706956522 0.834980237 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Propanoate metabolism 0 -0.581027668 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Proteasome 0 -0.476284585 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Protein export -0.442608696 -0.658102767 -0.441441441 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Protein processing in endoplasmic reticulum -0.712173913 -0.694664032 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Purine metabolism -0.531304348 -0.5 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Pyrimidine metabolism 0 -0.699604743 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Pyruvate metabolism 0 -0.690711462 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Rap1 signaling pathway 0 -0.444664032 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Ras signaling pathway 0 -0.740118577 -0.455341055 yes kegg kegg NA NA no no no no up up NOD-like receptor signaling pathway Renin-angiotensin system 0.64173913 0.657114625 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Retinol metabolism 0 -0.503952569 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Ribosome -0.548695652 -0.670948617 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Ribosome biogenesis in eukaryotes 0 -0.513833992 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway RNA degradation -0.419130435 -0.67687747 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway RNA polymerase 0 -0.635375494 -0.488288288 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Ruminococcus -0.484347826 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no NOD-like receptor signaling pathway SNARE interactions in vesicular transport 0 0.606719368 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Sphingolipid signaling pathway 0 0.587944664 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Starch and sucrose metabolism 0.674782609 0.730237154 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Steroid biosynthesis -0.486086957 -0.529644269 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Steroid hormone biosynthesis 0 -0.508893281 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Synthesis and degradation of ketone bodies 0 -0.580039526 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway TGF-beta signaling pathway -0.433913043 -0.633399209 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Thiamine metabolism 0 -0.511857708 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Tight junction 0 -0.561264822 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Toll-like receptor signaling pathway 0.486086957 0.909090909 0 yes kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Tyrosine metabolism 0 -0.68083004 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.551383399 -0.461261261 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Ubiquitin mediated proteolysis -0.77826087 -0.586956522 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway "Valine, leucine and isoleucine degradation" 0 -0.605731225 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Various types of N-glycan biosynthesis 0 -0.583992095 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Vascular smooth muscle contraction -0.62 -0.7756917 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway VEGF signaling pathway 0 0.470355731 0 kegg kegg NA NA no no no no no no NOD-like receptor signaling pathway Wnt signaling pathway -0.519130435 -0.761857708 -0.420849421 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease 2-Oxocarboxylic acid metabolism -0.626086957 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease ABC transporters -0.434782609 0 0 kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease Adherens junction 0 0.576086957 0.548777349 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Adrenergic signaling in cardiomyocytes 0.784347826 0.813241107 0.474131274 kegg kegg NA NA no no no no no up Non-alcoholic fatty liver disease "Alanine, aspartate and glutamate metabolism" -0.488695652 -0.697628458 -0.474131274 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Aldosterone synthesis and secretion 0.636521739 0.750988142 0.515057915 kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease alpha-Linolenic acid metabolism -0.666086957 -0.710474308 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Amino sugar and nucleotide sugar metabolism -0.636521739 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Aminoacyl-tRNA biosynthesis -0.640869565 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease AMPK signaling pathway 0 0.47826087 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Apelin signaling pathway 0 0.660079051 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Apoptosis -0.46173913 -0.468379447 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Apoptosis - multiple species 0 -0.416996047 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Arginine and proline metabolism 0 -0.726284585 -0.555469755 kegg kegg NA NA no no no no up no Non-alcoholic fatty liver disease Arginine biosynthesis -0.513043478 -0.647233202 -0.418275418 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Autophagy - animal 0 -0.601778656 -0.559330759 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Axon guidance 0.522608696 0 0 kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease B cell receptor signaling pathway 0 -0.529644269 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease beta-Alanine metabolism -0.790434783 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Biosynthesis of amino acids -0.839130435 -0.593873518 -0.416216216 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Biosynthesis of unsaturated fatty acids -0.492173913 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Butanoate metabolism -0.662608696 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Butyricimonas 0.4325094 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Non-alcoholic fatty liver disease C-type lectin receptor signaling pathway 0 -0.516798419 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Calcium signaling pathway 0.760869565 0.73715415 0 kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease cAMP signaling pathway 0.833913043 0 0 yes kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease Carbon metabolism -0.809565217 0 -0.454826255 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Cardiac muscle contraction 0.965217391 0.92687747 0.902445302 kegg kegg NA NA no no no no no up Non-alcoholic fatty liver disease Cell adhesion molecules -0.582608696 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease cGMP-PKG signaling pathway 0 -0.570158103 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Cholinergic synapse 0 -0.472332016 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Circadian entrainment 0 0.526679842 0.412355212 kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease Circadian rhythm 0.73826087 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Citrate cycle (TCA cycle) -0.416521739 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Complement and coagulation cascades -0.576521739 -0.603754941 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Cortisol synthesis and secretion 0.420869565 0.433794466 0.461518662 kegg kegg NA NA no no no no no up Non-alcoholic fatty liver disease Cytokine-cytokine receptor interaction 0 -0.446640316 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Dopaminergic synapse 0.706956522 0.695652174 0.431145431 kegg kegg NA NA no no no no up no Non-alcoholic fatty liver disease Drug metabolism - other enzymes -0.640869565 0.461462451 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease EGFR tyrosine kinase inhibitor resistance 0 0.590909091 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Endocrine resistance 0.462608696 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Endocytosis -0.466086957 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Ether lipid metabolism 0.72 0.421936759 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Fatty acid biosynthesis 0 -0.761857708 -0.591763192 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Fatty acid degradation -0.655652174 -0.853754941 -0.520978121 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Fatty acid elongation -0.623478261 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Fatty acid metabolism -0.792173913 -0.830039526 -0.444272844 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Fc epsilon RI signaling pathway 0 -0.616600791 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Fc gamma R-mediated phagocytosis -0.475652174 -0.622529644 -0.503732304 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Focal adhesion 0 0.420948617 0 kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease FoxO signaling pathway 0 -0.704545455 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Fructose and mannose metabolism -0.785217391 -0.52173913 -0.544401544 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease GABAergic synapse 0 -0.58201581 0 kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease Galactose metabolism -0.808695652 -0.808300395 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Glucagon signaling pathway 0.474782609 0.726284585 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Glutathione metabolism 0 0.657114625 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Glycerolipid metabolism 0 -0.591897233 0 kegg kegg NA NA no no no no no up Non-alcoholic fatty liver disease Glycolysis / Gluconeogenesis -0.692173913 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.641304348 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Glycosaminoglycan biosynthesis - keratan sulfate 0.537391304 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Glyoxylate and dicarboxylate metabolism -0.672173913 -0.652173913 -0.511196911 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease GnRH signaling pathway 0.422608696 0.513833992 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Hedgehog signaling pathway 0.571304348 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease HIF-1 signaling pathway 0 0.557312253 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Hippo signaling pathway 0 0.562252964 0.515057915 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Hippo signaling pathway - multiple species 0 -0.668972332 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Histidine metabolism -0.446086957 -0.415019763 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease IL-17 signaling pathway 0 -0.495059289 -0.45045045 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Inflammatory mediator regulation of TRP channels 0.582608696 0.765810277 0.441956242 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Inositol phosphate metabolism 0 -0.440711462 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Insulin resistance 0.414782609 -0.43972332 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Insulin secretion 0 0.558300395 0 yes kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease Insulin signaling pathway 0 0.59486166 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease JAK-STAT signaling pathway 0 -0.653162055 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Long-term depression 0.585217391 0.418972332 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Long-term potentiation 0.448695652 0 0 kegg kegg NA NA no no no no no up Non-alcoholic fatty liver disease Lysosome 0 0 -0.414414414 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Mannose type O-glycan biosynthesis 0.491304348 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease MAPK signaling pathway 0 -0.723320158 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Melanogenesis 0.52 0.806324111 0.514800515 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Mitophagy - animal 0.567826087 0.812252964 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease mRNA surveillance pathway 0.764347826 0.610671937 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease mTOR signaling pathway 0 0.590909091 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Mucin type O-glycan biosynthesis 0 -0.473320158 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease N-Glycan biosynthesis 0 0.447628458 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Natural killer cell mediated cytotoxicity -0.487826087 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Necroptosis 0 0.446640316 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Neuroactive ligand-receptor interaction 0 -0.496047431 -0.403603604 kegg kegg NA NA no no no up up up Non-alcoholic fatty liver disease Neurotrophin signaling pathway 0.57826087 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Neutrophil extracellular trap formation -0.492173913 -0.488142292 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease NF-kappa B signaling pathway 0 -0.621541502 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Nicotinate and nicotinamide metabolism 0 -0.661067194 -0.517117117 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Nitrogen metabolism -0.426086957 -0.527667984 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease NOD-like receptor signaling pathway 0 -0.663043478 -0.414157014 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Non-homologous end-joining -0.687826087 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Olfactory transduction 0 -0.57312253 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Oocyte meiosis 0.437391304 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Oscillospira 0 -0.510869565 0 LPS-producing kegg Genus NA 0.62 no no no no no no Non-alcoholic fatty liver disease Osteoclast differentiation 0 -0.658102767 -0.403861004 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Other glycan degradation 0 -0.461462451 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Ovarian steroidogenesis 0 0.421936759 0 kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease Oxidative phosphorylation 0.966086957 0.950592885 0.902960103 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Pantothenate and CoA biosynthesis 0 -0.738142292 -0.594079794 kegg kegg NA NA no no no no no dn Non-alcoholic fatty liver disease "Parathyroid hormone synthesis, secretion and action" 0.713043478 0.795454545 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Pentose phosphate pathway -0.526086957 -0.530632411 -0.474646075 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Peroxisome -0.573043478 -0.713438735 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Phagosome -0.608695652 -0.415019763 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Phosphatidylinositol signaling system 0.597391304 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Platelet activation 0 0.457509881 0.407207207 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease PPAR signaling pathway 0 -0.526679842 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Primary bile acid biosynthesis -0.44173913 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Prolactin signaling pathway 0 -0.556324111 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Protein export 0.543478261 0.697628458 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Protein processing in endoplasmic reticulum 0 0.555335968 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Pyrimidine metabolism -0.769565217 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Pyruvate metabolism 0 0.446640316 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Rap1 signaling pathway 0 0 0.409266409 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Regulation of lipolysis in adipocytes 0 0.423913043 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Relaxin signaling pathway 0.599130435 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Renin secretion 0 0.764822134 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Renin-angiotensin system 0 -0.567193676 -0.423166023 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Retinol metabolism -0.520869565 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Retrograde endocannabinoid signaling 0.793043478 0.868577075 0.616988417 kegg kegg NA NA no no no no no up Non-alcoholic fatty liver disease Ribosome 0.71826087 0.812252964 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease RIG-I-like receptor signaling pathway 0 -0.571146245 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease RNA degradation 0.710434783 0.592885375 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease RNA polymerase 0 0.469367589 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease RNA transport 0 0.468379447 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Ruminococcus 0 0.425459452 0 kegg Genus NA 0.0679 no no no no no dn Non-alcoholic fatty liver disease Signaling pathways regulating pluripotency of stem cells 0.662608696 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease SNARE interactions in vesicular transport 0 -0.604743083 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Sphingolipid signaling pathway 0.505217391 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Starch and sucrose metabolism -0.497391304 -0.793478261 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Sulfur metabolism -0.445217391 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Synaptic vesicle cycle 0 -0.554347826 0 kegg kegg NA NA no no no no up up Non-alcoholic fatty liver disease T cell receptor signaling pathway 0 -0.460474308 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease TGF-beta signaling pathway 0.688695652 0.572134387 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Thermogenesis 0.944347826 0.929841897 0.848133848 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Thyroid hormone signaling pathway 0 0.56916996 0.518661519 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Thyroid hormone synthesis 0 0.653162055 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Tight junction 0 0.459486166 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease TNF signaling pathway 0 -0.436758893 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Toll-like receptor signaling pathway 0 -0.538537549 0 yes kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Tryptophan metabolism -0.619130435 0 0 kegg kegg NA NA no no no no up no Non-alcoholic fatty liver disease Type II diabetes mellitus 0 -0.566205534 -0.441441441 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Ubiquinone and other terpenoid-quinone biosynthesis -0.452173913 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Ubiquitin mediated proteolysis 0.56173913 0.813241107 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease "Valine, leucine and isoleucine degradation" -0.526956522 0 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Vascular smooth muscle contraction 0.723478261 0.824110672 0 kegg kegg NA NA no no no no no no Non-alcoholic fatty liver disease Wnt signaling pathway 0.722608696 0.550395257 0 kegg kegg NA NA no no no no no no Non-homologous end-joining 2-Oxocarboxylic acid metabolism 0.808695652 0.481225296 0.464864865 kegg kegg NA NA no no no no no no Non-homologous end-joining ABC transporters 0.427826087 0 0 kegg kegg NA NA no no no no up up Non-homologous end-joining alpha-Linolenic acid metabolism 0.619130435 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Amino sugar and nucleotide sugar metabolism 0.682608696 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Aminoacyl-tRNA biosynthesis 0.753043478 0.453557312 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Base excision repair 0 0 0.516087516 kegg kegg NA NA no no no no no no Non-homologous end-joining beta-Alanine metabolism 0.854782609 0.808300395 0.721750322 kegg kegg NA NA no no no no no no Non-homologous end-joining Biosynthesis of amino acids 0.623478261 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Biosynthesis of cofactors 0.451304348 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Biosynthesis of unsaturated fatty acids 0.79826087 0.78458498 0.588931789 kegg kegg NA NA no no no no no no Non-homologous end-joining Butanoate metabolism 0.884347826 0.807312253 0.762676963 kegg kegg NA NA no no no no no no Non-homologous end-joining Carbon metabolism 0.812173913 0.699604743 0.417760618 kegg kegg NA NA no no no no no no Non-homologous end-joining Citrate cycle (TCA cycle) 0.828695652 0.804347826 0.622136422 kegg kegg NA NA no no no no no no Non-homologous end-joining Cysteine and methionine metabolism 0.600869565 0.834980237 0.587387387 kegg kegg NA NA no no no no no no Non-homologous end-joining DNA replication 0.602608696 0.621541502 0.457142857 kegg kegg NA NA no no no no no no Non-homologous end-joining Drug metabolism - cytochrome P450 0.424347826 0.686758893 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Drug metabolism - other enzymes 0.755652174 0.65513834 0 kegg kegg NA NA no no no no no no Non-homologous end-joining EGFR tyrosine kinase inhibitor resistance 0 0.420948617 0.440669241 kegg kegg NA NA no no no no no no Non-homologous end-joining Ether lipid metabolism -0.524347826 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Fatty acid degradation 0.546956522 0 0.42985843 kegg kegg NA NA no no no no no no Non-homologous end-joining Fatty acid elongation 0.788695652 0.896245059 0.726640927 kegg kegg NA NA no no no no no no Non-homologous end-joining Fatty acid metabolism 0.59826087 0 0.414157014 kegg kegg NA NA no no no no no no Non-homologous end-joining Fructose and mannose metabolism 0.626956522 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Galactose metabolism 0.613913043 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Glycolysis / Gluconeogenesis 0.866956522 0.835968379 0.631917632 kegg kegg NA NA no no no no no no Non-homologous end-joining Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.65513834 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.60173913 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Glycosaminoglycan biosynthesis - keratan sulfate -0.493913043 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Glycosphingolipid biosynthesis - lacto and neolacto series -0.62173913 -0.557312253 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Histidine metabolism 0.508695652 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Homologous recombination 0.469565217 0 0.431145431 kegg kegg NA NA no no no no no no Non-homologous end-joining Mannose type O-glycan biosynthesis -0.540869565 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Metabolism of xenobiotics by cytochrome P450 0.526086957 0.731225296 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Mismatch repair 0.717391304 0.765810277 0.644272844 kegg kegg NA NA no no no no no no Non-homologous end-joining mRNA surveillance pathway -0.577391304 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Mucin type O-glycan biosynthesis 0.537391304 0 0.413899614 kegg kegg NA NA no no no no no no Non-homologous end-joining Nucleotide excision repair 0.615652174 0.596837945 0.546460746 kegg kegg NA NA no no no no no no Non-homologous end-joining One carbon pool by folate 0.562608696 0.501976285 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Oxidative phosphorylation -0.593043478 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Pentose and glucuronate interconversions 0.639130435 0.600790514 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Phenylalanine metabolism 0.697391304 0.721343874 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Primary bile acid biosynthesis 0.785217391 0.889328063 0.519176319 kegg kegg NA NA no no no no no no Non-homologous end-joining Propanoate metabolism 0.694782609 0.850790514 0.661003861 kegg kegg NA NA no no no no no no Non-homologous end-joining Proteasome 0 0.647233202 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Pyrimidine metabolism 0.732173913 0.480237154 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Pyruvate metabolism 0.695652174 0.750988142 0.71016731 kegg kegg NA NA no no no no no no Non-homologous end-joining Retinol metabolism 0.771304348 0.644268775 0.497812098 kegg kegg NA NA no no no no no no Non-homologous end-joining Ribosome -0.486956522 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining RNA degradation -0.523478261 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining RNA transport 0.42 0.502964427 0.541570142 kegg kegg NA NA no no no no no no Non-homologous end-joining Steroid biosynthesis 0 0.708498024 0.43011583 kegg kegg NA NA no no no no no no Non-homologous end-joining Steroid hormone biosynthesis 0.573913043 0.721343874 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Sulfur metabolism 0.44173913 0 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Synthesis and degradation of ketone bodies 0.642608696 0.645256917 0.583268983 kegg kegg NA NA no no no no no no Non-homologous end-joining Taurine and hypotaurine metabolism 0 -0.62944664 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Terpenoid backbone biosynthesis 0 0.425889328 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Thiamine metabolism 0.457391304 0.656126482 0 kegg kegg NA NA no no no no no no Non-homologous end-joining Tryptophan metabolism 0.85826087 0.866600791 0.719433719 kegg kegg NA NA no no no no up no Non-homologous end-joining Tyrosine metabolism 0.779130435 0.777667984 0.757528958 kegg kegg NA NA no no no no no no Non-homologous end-joining Ubiquinone and other terpenoid-quinone biosynthesis 0.689565217 0.690711462 0.501930502 kegg kegg NA NA no no no no no no Non-homologous end-joining "Valine, leucine and isoleucine degradation" 0.810434783 0.714426877 0.686486486 kegg kegg NA NA no no no no no no Non-small cell lung cancer 2-Oxocarboxylic acid metabolism -0.439130435 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer ABC transporters 0 0.698616601 0.426512227 kegg kegg NA NA no no no no up up Non-small cell lung cancer Acute myeloid leukemia 0.590434783 0.627470356 0.501158301 kegg kegg NA NA no no no no no no Non-small cell lung cancer Adherens junction -0.420869565 -0.545454545 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Adipocytokine signaling pathway 0 0.447628458 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer AGE-RAGE signaling pathway in diabetic complications 0.54 0.494071146 0.448133848 kegg kegg NA NA no no no no no no Non-small cell lung cancer Alcoholism 0 0 -0.461003861 kegg kegg NA NA no no no no no no Non-small cell lung cancer Aldosterone-regulated sodium reabsorption 0.731304348 0.509881423 0.591248391 kegg kegg NA NA no no no no no no Non-small cell lung cancer Alzheimer disease 0 -0.423913043 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Amino sugar and nucleotide sugar metabolism -0.591304348 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Amoebiasis 0 0.424901186 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Anaerostipes 0 0 -0.401243218 butyrate-producing kegg Genus NA 0.568 no no no no no no Non-small cell lung cancer Antigen processing and presentation 0 -0.513833992 -0.515572716 kegg kegg NA NA no no no no no no Non-small cell lung cancer Apelin signaling pathway 0 -0.56027668 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Apoptosis - multiple species 0 0.538537549 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Arachidonic acid metabolism -0.693913043 0 -0.633462033 kegg kegg NA NA no no no no no no Non-small cell lung cancer Autophagy - animal 0.626956522 0.66798419 0.551351351 kegg kegg NA NA no no no no no no Non-small cell lung cancer Autophagy - other 0.532173913 0.578063241 0.609009009 kegg kegg NA NA no no no no no no Non-small cell lung cancer Axon guidance 0.444347826 0 0 kegg kegg NA NA no no no no up up Non-small cell lung cancer B cell receptor signaling pathway 0.49826087 0.450592885 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Bacterial invasion of epithelial cells -0.495652174 -0.62055336 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Basal cell carcinoma 0.513043478 0.513833992 0.685714286 kegg kegg NA NA no no no no no no Non-small cell lung cancer Basal transcription factors 0 0 0.411068211 kegg kegg NA NA no no no no no no Non-small cell lung cancer beta-Alanine metabolism -0.543478261 -0.674901186 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Biosynthesis of amino acids 0 0 -0.543629344 kegg kegg NA NA no no no no no no Non-small cell lung cancer Biosynthesis of cofactors -0.579130435 0 -0.426769627 kegg kegg NA NA no no no no no no Non-small cell lung cancer Biosynthesis of unsaturated fatty acids -0.513913043 -0.622529644 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Bladder cancer 0 0.516798419 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Butanoate metabolism -0.506956522 -0.57312253 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer C-type lectin receptor signaling pathway 0.65826087 0.469367589 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer cAMP signaling pathway 0.468695652 0 0 yes kegg kegg NA NA no no no no up up Non-small cell lung cancer Carbohydrate digestion and absorption 0.86173913 0.867588933 0.781467181 kegg kegg NA NA no no no no no no Non-small cell lung cancer Carbon metabolism -0.547826087 -0.586956522 -0.442213642 kegg kegg NA NA no no no no no no Non-small cell lung cancer Cell cycle 0 0 0.502445302 kegg kegg NA NA no no no no no no Non-small cell lung cancer Chagas disease 0.665217391 0.618577075 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Chemical carcinogenesis - DNA adducts -0.62173913 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Chemical carcinogenesis - receptor activation 0 0.514822134 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Chemokine signaling pathway 0.451304348 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Cholinergic synapse 0.550434783 0 0.665379665 kegg kegg NA NA no no no no no no Non-small cell lung cancer Chronic myeloid leukemia 0.809565217 0.695652174 0.434234234 kegg kegg NA NA no no no no no no Non-small cell lung cancer Circadian entrainment 0 -0.489130435 -0.433719434 kegg kegg NA NA no no no no up up Non-small cell lung cancer Circadian rhythm 0.536521739 0 0.64041184 kegg kegg NA NA no no no no no no Non-small cell lung cancer Citrate cycle (TCA cycle) -0.535652174 -0.64229249 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Clostridium 0 -0.609245673 0 kegg Genus NA 0.925 no no no no no no Non-small cell lung cancer Collecting duct acid secretion -0.454782609 -0.553359684 -0.504247104 kegg kegg NA NA no no no no no no Non-small cell lung cancer Colorectal cancer 0.693913043 0.502964427 0.816216216 kegg kegg NA NA no no no no no no Non-small cell lung cancer Complement and coagulation cascades 0 0 -0.443758044 kegg kegg NA NA no no no no no no Non-small cell lung cancer Coronavirus disease - COVID-19 0 -0.524703557 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Cysteine and methionine metabolism -0.413043478 -0.650197628 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Drug metabolism - cytochrome P450 -0.586956522 -0.581027668 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Drug metabolism - other enzymes -0.699130435 -0.66798419 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer EGFR tyrosine kinase inhibitor resistance 0 -0.415019763 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Endocrine resistance 0.405217391 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Endometrial cancer 0.88 0.793478261 0.765508366 kegg kegg NA NA no no no no no no Non-small cell lung cancer ErbB signaling pathway 0.932173913 0.924901186 0.844272844 kegg kegg NA NA no no no no no no Non-small cell lung cancer Estrogen signaling pathway 0 -0.43083004 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Fatty acid elongation -0.615652174 -0.703557312 -0.409266409 kegg kegg NA NA no no no no no no Non-small cell lung cancer Fc epsilon RI signaling pathway 0.693043478 0.538537549 0.475675676 kegg kegg NA NA no no no no no no Non-small cell lung cancer Ferroptosis 0 0 -0.531788932 kegg kegg NA NA no no no no no no Non-small cell lung cancer Focal adhesion 0 -0.651185771 0 kegg kegg NA NA no no no no up up Non-small cell lung cancer FoxO signaling pathway 0.486086957 0.672924901 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Fructose and mannose metabolism 0 0.592885375 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Galactose metabolism 0 0.448616601 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Gastric acid secretion -0.460869565 -0.533596838 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Glioma 0.580869565 0 0.632175032 kegg kegg NA NA no no no no no no Non-small cell lung cancer Glutamatergic synapse 0 0.504940711 0 kegg kegg NA NA no no no no up up Non-small cell lung cancer Glutathione metabolism -0.547826087 -0.462450593 -0.671299871 kegg kegg NA NA no no no no no no Non-small cell lung cancer Glycerolipid metabolism 0 0.743083004 0.675933076 kegg kegg NA NA no no no no no up Non-small cell lung cancer Glycerophospholipid metabolism 0.410434783 0.585968379 0.705534106 kegg kegg NA NA no no no no no up Non-small cell lung cancer "Glycine, serine and threonine metabolism" -0.470434783 0 -0.406692407 kegg kegg NA NA no no no no up no Non-small cell lung cancer Glycolysis / Gluconeogenesis -0.574782609 -0.785573123 -0.424710425 kegg kegg NA NA no no no no no no Non-small cell lung cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.804347826 0.553925354 kegg kegg NA NA no no no no no no Non-small cell lung cancer Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.413043478 0 0.52998713 kegg kegg NA NA no no no no no no Non-small cell lung cancer Glycosaminoglycan biosynthesis - keratan sulfate 0.411304348 0 0.548005148 kegg kegg NA NA no no no no no no Non-small cell lung cancer Glycosaminoglycan degradation 0 0 0.433976834 kegg kegg NA NA no no no no no up Non-small cell lung cancer Glycosphingolipid biosynthesis - globo and isoglobo series -0.510434783 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Glycosphingolipid biosynthesis - lacto and neolacto series 0.464347826 0.502964427 0.491119691 kegg kegg NA NA no no no no no no Non-small cell lung cancer GnRH secretion 0.937391304 0.960474308 0.932046332 kegg kegg NA NA no no no no up up Non-small cell lung cancer "Growth hormone synthesis, secretion and action" 0.666956522 0.760869565 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Hedgehog signaling pathway 0.508695652 0 0.767310167 kegg kegg NA NA no no no no no no Non-small cell lung cancer Hematopoietic cell lineage 0 -0.590909091 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Hepatitis B 0.748695652 0.633399209 0.54980695 kegg kegg NA NA no no no no no no Non-small cell lung cancer Hepatitis C 0.509565217 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer HIF-1 signaling pathway 0 -0.548418972 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Hippo signaling pathway 0 -0.482213439 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Hippo signaling pathway - multiple species 0 0 0.577606178 kegg kegg NA NA no no no no no no Non-small cell lung cancer Histidine metabolism -0.423478261 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Human papillomavirus infection 0 0.42687747 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Human T-cell leukemia virus 1 infection 0 0 -0.404633205 kegg kegg NA NA no no no no no no Non-small cell lung cancer Inositol phosphate metabolism 0 0.646245059 0.724324324 kegg kegg NA NA no no no no no no Non-small cell lung cancer Insulin resistance 0.733913043 0.781620553 0.572200772 kegg kegg NA NA no no no no no no Non-small cell lung cancer Insulin signaling pathway 0 -0.53458498 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer JAK-STAT signaling pathway 0 0.773715415 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Kaposi sarcoma-associated herpesvirus infection 0 0 -0.485714286 kegg kegg NA NA no no no no no dn Non-small cell lung cancer Lachnospira 0 -0.529280965 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Non-small cell lung cancer Legionellosis 0 0 -0.529472329 kegg kegg NA NA no no no no no no Non-small cell lung cancer Leishmaniasis 0 -0.457509881 -0.587387387 kegg kegg NA NA no no no no no no Non-small cell lung cancer Leukocyte transendothelial migration 0 -0.479249012 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Linoleic acid metabolism -0.485217391 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Long-term potentiation 0 -0.59486166 0.435521236 kegg kegg NA NA no no no no no up Non-small cell lung cancer Longevity regulating pathway 0.450434783 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Lysine degradation 0.472173913 0.539525692 0.684684685 kegg kegg NA NA no no no no no no Non-small cell lung cancer Malaria 0 0 -0.515830116 kegg kegg NA NA no no no no no no Non-small cell lung cancer Mannose type O-glycan biosynthesis 0.622608696 0.558300395 0.670785071 kegg kegg NA NA no no no no no no Non-small cell lung cancer MAPK signaling pathway 0 0 0.682882883 kegg kegg NA NA no no no no no no Non-small cell lung cancer Melanoma 0.765217391 0.755928854 0.741312741 kegg kegg NA NA no no no no no no Non-small cell lung cancer Metabolism of xenobiotics by cytochrome P450 -0.648695652 -0.646245059 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer MicroRNAs in cancer 0.451304348 0.71541502 0.760875161 kegg kegg NA NA no no no no no no Non-small cell lung cancer Mineral absorption 0 0 -0.503989704 kegg kegg NA NA no no no no no no Non-small cell lung cancer Mismatch repair -0.47826087 -0.459486166 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Mitophagy - animal 0 0 -0.462033462 kegg kegg NA NA no no no no no no Non-small cell lung cancer mRNA surveillance pathway 0.479130435 0 0.591248391 kegg kegg NA NA no no no no no no Non-small cell lung cancer mTOR signaling pathway 0 -0.448616601 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer N-Glycan biosynthesis 0 0 0.434491634 kegg kegg NA NA no no no no no no Non-small cell lung cancer Necroptosis 0 0 -0.521750322 kegg kegg NA NA no no no no no no Non-small cell lung cancer Neurotrophin signaling pathway 0.68 0.501976285 0.411840412 kegg kegg NA NA no no no no no no Non-small cell lung cancer Neutrophil extracellular trap formation 0 0 -0.428828829 kegg kegg NA NA no no no no no no Non-small cell lung cancer NF-kappa B signaling pathway 0.616521739 0.670948617 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Nicotine addiction 0 0.668972332 0 kegg kegg NA NA no no no no up up Non-small cell lung cancer Non-homologous end-joining -0.523478261 -0.679841897 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Notch signaling pathway 0.493913043 0.732213439 0.703732304 kegg kegg NA NA no no no no no no Non-small cell lung cancer Oocyte meiosis 0 -0.671936759 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Other glycan degradation 0 0.601778656 0.570913771 kegg kegg NA NA no no no no no no Non-small cell lung cancer Other types of O-glycan biosynthesis 0.406086957 0.544466403 0.662548263 kegg kegg NA NA no no no no no no Non-small cell lung cancer Oxidative phosphorylation 0 -0.422924901 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Oxytocin signaling pathway -0.476521739 -0.494071146 -0.502445302 kegg kegg NA NA no no no no no no Non-small cell lung cancer p53 signaling pathway 0.473043478 0.538537549 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Pancreatic cancer 0.557391304 0.526679842 0.51042471 kegg kegg NA NA no no no no no no Non-small cell lung cancer Pathways in cancer 0.647826087 0.764822134 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Pentose and glucuronate interconversions -0.671304348 -0.501976285 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Phenylalanine metabolism -0.55826087 -0.522727273 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Phosphatidylinositol signaling system 0.491304348 0 0.75984556 kegg kegg NA NA no no no no no no Non-small cell lung cancer Phospholipase D signaling pathway 0.566956522 0.733201581 0 kegg kegg NA NA no no no no up up Non-small cell lung cancer Phototransduction 0 -0.894268775 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Platelet activation -0.482608696 -0.523715415 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Platinum drug resistance 0.44173913 0.571146245 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Porphyrin and chlorophyll metabolism -0.446956522 0 -0.455083655 kegg kegg NA NA no no no no no no Non-small cell lung cancer Primary bile acid biosynthesis -0.563478261 -0.777667984 -0.404890605 kegg kegg NA NA no no no no no no Non-small cell lung cancer Prion disease 0 -0.505928854 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Progesterone-mediated oocyte maturation 0.564347826 0.618577075 0.796911197 kegg kegg NA NA no no no no no no Non-small cell lung cancer Prolactin signaling pathway 0.684347826 0.559288538 0.522779923 kegg kegg NA NA no no no no no no Non-small cell lung cancer Propanoate metabolism -0.439130435 -0.688735178 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Prostate cancer 0.78173913 0.65513834 0.438095238 kegg kegg NA NA no no no no no no Non-small cell lung cancer Proteasome 0 -0.747035573 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Protein export 0 -0.555335968 0.402059202 kegg kegg NA NA no no no no no no Non-small cell lung cancer Pyrimidine metabolism -0.525217391 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Pyruvate metabolism -0.437391304 -0.653162055 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Ras signaling pathway 0 0 0.552638353 yes kegg kegg NA NA no no no no up up Non-small cell lung cancer Regulation of actin cytoskeleton -0.625217391 -0.81916996 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Relaxin signaling pathway 0.523478261 0.57312253 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Renal cell carcinoma 0.504347826 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Renin secretion -0.425217391 -0.470355731 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Retinol metabolism -0.499130435 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Retrograde endocannabinoid signaling 0 -0.507905138 0 kegg kegg NA NA no no no no no up Non-small cell lung cancer Ribosome 0 -0.511857708 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Ribosome biogenesis in eukaryotes 0 0 0.41981982 kegg kegg NA NA no no no no no no Non-small cell lung cancer RIG-I-like receptor signaling pathway 0.587826087 0.609683794 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer RNA degradation 0.44173913 0 0.537194337 kegg kegg NA NA no no no no no no Non-small cell lung cancer RNA transport 0 -0.422924901 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Roseburia -0.406086957 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no Non-small cell lung cancer Ruminococcus 0 -0.47548437 0 kegg Genus NA 0.0679 no no no no no dn Non-small cell lung cancer Salivary secretion 0 0 -0.427284427 kegg kegg NA NA no no no no no no Non-small cell lung cancer Selenocompound metabolism 0 0 0.473359073 kegg kegg NA NA no no no no no no Non-small cell lung cancer Shigellosis 0 0 -0.58018018 kegg kegg NA NA no no no no no no Non-small cell lung cancer Signaling pathways regulating pluripotency of stem cells 0.808695652 0.726284585 0.848133848 kegg kegg NA NA no no no no no no Non-small cell lung cancer Small cell lung cancer 0.677391304 0.699604743 0 kegg kegg NA NA no no no no no up Non-small cell lung cancer SNARE interactions in vesicular transport 0 0.575098814 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Sphingolipid signaling pathway 0.62173913 0 0.668211068 kegg kegg NA NA no no no no no no Non-small cell lung cancer Spinocerebellar ataxia 0.567826087 0 0.543886744 kegg kegg NA NA no no no no no no Non-small cell lung cancer Spliceosome 0 0.562252964 0.448648649 kegg kegg NA NA no no no no no no Non-small cell lung cancer Staphylococcus aureus infection 0 0 -0.485456885 kegg kegg NA NA no no no up no no Non-small cell lung cancer Steroid biosynthesis 0 -0.589920949 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Steroid hormone biosynthesis -0.752173913 -0.539525692 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Sulfur metabolism -0.635652174 -0.488142292 -0.559073359 kegg kegg NA NA no no no no no no Non-small cell lung cancer T cell receptor signaling pathway 0.493043478 0.542490119 0.416473616 kegg kegg NA NA no no no no no no Non-small cell lung cancer Taste transduction 0 0 0.708880309 kegg kegg NA NA no no no no no up Non-small cell lung cancer Taurine and hypotaurine metabolism 0.520869565 0.835968379 0.585585586 kegg kegg NA NA no no no no no no Non-small cell lung cancer TGF-beta signaling pathway 0 -0.589920949 0.45971686 kegg kegg NA NA no no no no no no Non-small cell lung cancer Thermogenesis 0 -0.424901186 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Thiamine metabolism 0 -0.616600791 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Thyroid cancer 0 -0.46541502 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Thyroid hormone synthesis 0 0 -0.44967825 kegg kegg NA NA no no no no no no Non-small cell lung cancer Tight junction -0.633043478 -0.700592885 -0.580694981 kegg kegg NA NA no no no no no no Non-small cell lung cancer TNF signaling pathway 0.76 0.684782609 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Toll-like receptor signaling pathway 0.673913043 0.43083004 0 yes kegg kegg NA NA no no no no no no Non-small cell lung cancer Transcriptional misregulation in cancer 0.520869565 0.658102767 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Tryptophan metabolism -0.571304348 -0.691699605 0 kegg kegg NA NA no no no no up no Non-small cell lung cancer Type II diabetes mellitus 0.82 0.822134387 0.673101673 kegg kegg NA NA no no no no no no Non-small cell lung cancer Tyrosine metabolism -0.648695652 -0.565217391 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Ubiquinone and other terpenoid-quinone biosynthesis -0.576521739 0 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Ubiquitin mediated proteolysis 0 0 -0.461261261 kegg kegg NA NA no no no no no no Non-small cell lung cancer "Valine, leucine and isoleucine degradation" -0.49826087 -0.494071146 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Various types of N-glycan biosynthesis 0 0 0.417760618 kegg kegg NA NA no no no no no no Non-small cell lung cancer Vascular smooth muscle contraction 0 -0.502964427 -0.402316602 kegg kegg NA NA no no no no no no Non-small cell lung cancer VEGF signaling pathway 0.786956522 0.725296443 0.755984556 kegg kegg NA NA no no no no no no Non-small cell lung cancer Vibrio cholerae infection -0.42173913 -0.497035573 0 kegg kegg NA NA no no no no no no Non-small cell lung cancer Viral protein interaction with cytokine and cytokine receptor 0 0 -0.508365508 kegg kegg NA NA no no no no no no Non-small cell lung cancer Vitamin digestion and absorption 0 0 0.531788932 kegg kegg NA NA no no no no no no Non-small cell lung cancer Wnt signaling pathway 0 0 0.661776062 kegg kegg NA NA no no no no no no nonanoic acid C9+blood 14:0/18:0-PC+blood 0 0 -0.424957265 serum_mcfa serum_phospholipids 6.51E-11 0.00289 dn dn no up up no nonanoic acid C9+blood 16:0/16:1-PC+blood 0 0 -0.463247863 serum_mcfa serum_phospholipids 6.51E-11 0.00283 dn dn no up up no nonanoic acid C9+blood 16:0/16:1-PI+blood 0 0 -0.471452991 serum_mcfa serum_phospholipids 6.51E-11 0.262 dn dn no no no no nonanoic acid C9+blood 16:0/18:2-PI+blood 0 0 -0.43042735 serum_mcfa serum_phospholipids 6.51E-11 0.269 dn dn no no no no nonanoic acid C9+blood 16:0/18:3-PC+blood 0 0 -0.44957265 serum_mcfa serum_phospholipids 6.51E-11 0.00216 dn dn no no up up nonanoic acid C9+blood 16:0/20:3-PC+blood 0 0.634803922 0 serum_mcfa serum_phospholipids 6.51E-11 5.43E-06 dn dn no no up up nonanoic acid C9+blood 16:1/18:2-PG+blood 0 0 0.442051282 serum_mcfa serum_phospholipids 6.51E-11 1.40E-08 dn dn no no up up nonanoic acid C9+blood 18:0/20:3-PC+blood 0 0 -0.490598291 serum_mcfa serum_phospholipids 6.51E-11 0.0682 dn dn no no up no nonanoic acid C9+blood 18:0/22:6-PC+blood 0 -0.512254902 0 serum_mcfa serum_phospholipids 6.51E-11 0.0775 dn dn no no no up nonanoic acid C9+blood 18:0/22:6-PE+blood 0 -0.5 0 serum_mcfa serum_phospholipids 6.51E-11 0.00022 dn dn no up up no nonanoic acid C9+blood 18:1/18:1-PC+blood 0 0.671568627 0 serum_mcfa serum_phospholipids 6.51E-11 1.34E-05 dn dn no no up up nonanoic acid C9+blood 18:1/20:3-PC+blood 0 0.659313725 -0.44 serum_mcfa serum_phospholipids 6.51E-11 0.00872 dn dn no no up up nonanoic acid C9+blood 18:1/20:4-PI+blood 0 0 -0.581538462 serum_mcfa serum_phospholipids 6.51E-11 0.192 dn dn no no no no nonanoic acid C9+blood 18:2-LPE+blood 0 0.610294118 0 serum_mcfa serum_phospholipids 6.51E-11 0.112 dn dn no no no no nonanoic acid C9+blood 18:3/16:0-PE+blood -0.473684211 0 0 serum_mcfa serum_phospholipids 6.51E-11 0.00149 dn dn no up up no nonanoic acid C9+blood 18:3n6+blood 0 0 -0.465982906 serum_mcfa serum_fattyacid 6.51E-11 0.0463 dn dn no up no dn nonanoic acid C9+blood 2-methyl-butyric acid m-C4+blood 0.560902256 0 0 serum_mcfa serum_scfa 6.51E-11 0.262 dn dn no no no no nonanoic acid C9+blood 20:0/20:4-PE+blood -0.482706767 0 0 serum_mcfa serum_phospholipids 6.51E-11 0.00128 dn dn no up up no nonanoic acid C9+blood 20:2-LPE+blood -0.544360902 0 0 serum_mcfa serum_phospholipids 6.51E-11 0.177 dn dn no no no no nonanoic acid C9+blood 20:2/18:0-PC+blood 0 0 -0.474188034 serum_mcfa serum_phospholipids 6.51E-11 0.0427 dn dn no no up no nonanoic acid C9+blood 20:2+blood 0 0.632352941 0 serum_mcfa serum_fattyacid 6.51E-11 0.478 dn dn no no no no nonanoic acid C9+blood 20:3-LPE+blood 0 0.629901961 -0.416752137 serum_mcfa serum_phospholipids 6.51E-11 0.084 dn dn no no up no nonanoic acid C9+blood 20:3n6+blood 0 0.504901961 0 serum_mcfa serum_fattyacid 6.51E-11 0.0884 dn dn no up no no nonanoic acid C9+blood 20:5-LPC+blood 0 -0.713235294 0 serum_mcfa serum_phospholipids 6.51E-11 0.558 dn dn no no no no nonanoic acid C9+blood 22:2-LPA+blood 0 0 -0.407863248 serum_mcfa serum_phospholipids 6.51E-11 0.0443 dn dn no dn no no nonanoic acid C9+blood 22:6-LPC+blood 0 -0.654411765 0 serum_mcfa serum_phospholipids 6.51E-11 0.127 dn dn no no no up nonanoic acid C9+blood 22:6n3+blood 0 -0.5 0 serum_mcfa serum_fattyacid 6.51E-11 0.792 dn dn no no no no nonanoic acid C9+blood acetic acid C2+blood 0.47518797 0 0 serum_mcfa serum_scfa 6.51E-11 0.000193 dn dn no up dn no nonanoic acid C9+blood capric acid C6+blood 0 0 0.410598291 serum_mcfa serum_scfa 6.51E-11 0.433 dn dn no no no no nonanoic acid C9+blood Cysteine+blood 0 0.50245098 0 yes serum_mcfa serum_aminoacids 6.51E-11 1.81E-07 dn dn no dn up up nonanoic acid C9+blood d18:1-18:0-SM+blood 0 -0.539215686 0 serum_mcfa serum_phospholipids 6.51E-11 0.97 dn dn no no no no nonanoic acid C9+blood d18:1-20:0-SM+blood -0.455639098 0 0 serum_mcfa serum_phospholipids 6.51E-11 0.933 dn dn no no no no nonanoic acid C9+blood decanoic acid C10+blood 0.843609023 0.757352941 0.474188034 serum_mcfa serum_mcfa 6.51E-11 6.64E-11 dn dn no dn dn no nonanoic acid C9+blood HDCA+blood 0 0 0.410882541 serum_mcfa serum_bileacids 6.51E-11 0.483 dn dn no no no no nonanoic acid C9+blood heptanoic acid C7+blood 0.932330827 0.727941176 0.461196581 serum_mcfa serum_mcfa 6.51E-11 8.27E-11 dn dn no dn dn no nonanoic acid C9+blood iso-heptanoic acid C7+blood 0.485714286 0 0 serum_mcfa serum_mcfa 6.51E-11 0.00256 dn dn no up up no nonanoic acid C9+blood isobutyric acid C4+blood 0.509774436 0 0 serum_mcfa serum_scfa 6.51E-11 0.0151 dn dn no up up no nonanoic acid C9+blood L-Alanine+blood 0 0 -0.565128205 yes serum_mcfa serum_aminoacids 6.51E-11 0.00138 dn dn no up up no nonanoic acid C9+blood L-Asparagine+blood 0.517293233 0 0 serum_mcfa serum_aminoacids 6.51E-11 0.784 dn dn no no no no nonanoic acid C9+blood lauric acid C12+blood 0.581954887 0.919117647 0.742222222 serum_mcfa serum_mcfa 6.51E-11 0.015 dn dn no no dn dn nonanoic acid C9+blood n3+blood 0 -0.536764706 0 serum_mcfa serum_fattyacid 6.51E-11 0.806 dn dn no no no no nonanoic acid C9+blood n6/n3+blood 0 0.659313725 0 serum_mcfa serum_fattyacid 6.51E-11 0.226 dn dn no no no no Notch signaling pathway 2-Oxocarboxylic acid metabolism -0.550434783 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway ABC transporters 0 0.48715415 0.593050193 kegg kegg NA NA no no no no up up Notch signaling pathway "Alanine, aspartate and glutamate metabolism" 0 0 -0.408494208 kegg kegg NA NA no no no no no no Notch signaling pathway alpha-Linolenic acid metabolism -0.455652174 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Amino sugar and nucleotide sugar metabolism -0.603478261 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Aminoacyl-tRNA biosynthesis -0.54 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway AMPK signaling pathway 0 0 -0.632175032 kegg kegg NA NA no no no no no no Notch signaling pathway Antifolate resistance 0 0 0.636808237 kegg kegg NA NA no no no no no no Notch signaling pathway Apoptosis - multiple species 0 0.440711462 0 kegg kegg NA NA no no no no no no Notch signaling pathway Arachidonic acid metabolism 0 0 -0.432689833 kegg kegg NA NA no no no no no no Notch signaling pathway Arginine biosynthesis 0 0 -0.499356499 kegg kegg NA NA no no no no no no Notch signaling pathway Ascorbate and aldarate metabolism 0 0 0.572458172 kegg kegg NA NA no no no no no no Notch signaling pathway Autophagy - animal 0 0.566205534 0 kegg kegg NA NA no no no no no no Notch signaling pathway Autophagy - other 0 0 0.516344916 kegg kegg NA NA no no no no no no Notch signaling pathway Basal transcription factors 0 0 0.51016731 kegg kegg NA NA no no no no no no Notch signaling pathway beta-Alanine metabolism -0.497391304 -0.458498024 0 kegg kegg NA NA no no no no no no Notch signaling pathway Biosynthesis of amino acids -0.475652174 0 -0.524581725 kegg kegg NA NA no no no no no no Notch signaling pathway Biosynthesis of cofactors -0.522608696 0 -0.457657658 kegg kegg NA NA no no no no no no Notch signaling pathway Biosynthesis of unsaturated fatty acids -0.473913043 -0.532608696 0 kegg kegg NA NA no no no no no no Notch signaling pathway Butanoate metabolism -0.505217391 -0.475296443 0 kegg kegg NA NA no no no no no no Notch signaling pathway cAMP signaling pathway 0.42 0 0 yes kegg kegg NA NA no no no no up up Notch signaling pathway Carbon metabolism -0.613913043 -0.511857708 0 kegg kegg NA NA no no no no no no Notch signaling pathway Cell cycle 0 0 0.518404118 kegg kegg NA NA no no no no no no Notch signaling pathway cGMP-PKG signaling pathway 0.567826087 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Citrate cycle (TCA cycle) -0.486956522 -0.488142292 0 kegg kegg NA NA no no no no no no Notch signaling pathway Cysteine and methionine metabolism -0.586086957 -0.574110672 0 kegg kegg NA NA no no no no no no Notch signaling pathway DNA replication 0 0 0.44015444 kegg kegg NA NA no no no no no no Notch signaling pathway Drug metabolism - cytochrome P450 -0.712173913 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Drug metabolism - other enzymes -0.559130435 -0.502964427 0.433719434 kegg kegg NA NA no no no no no no Notch signaling pathway Endocrine resistance 0 0.518774704 0 kegg kegg NA NA no no no no no no Notch signaling pathway ErbB signaling pathway 0.556521739 0.670948617 0.58970399 kegg kegg NA NA no no no no no no Notch signaling pathway Ether lipid metabolism 0.425217391 0 0.506563707 kegg kegg NA NA no no no no no no Notch signaling pathway Fanconi anemia pathway 0 0 0.447361647 kegg kegg NA NA no no no no no no Notch signaling pathway Fatty acid elongation 0 -0.592885375 0 kegg kegg NA NA no no no no no no Notch signaling pathway Ferroptosis 0 0 -0.545945946 kegg kegg NA NA no no no no no no Notch signaling pathway Folate biosynthesis 0 0 0.553410553 kegg kegg NA NA no no no no no no Notch signaling pathway FoxO signaling pathway 0 0.473320158 0 kegg kegg NA NA no no no no no no Notch signaling pathway Fructose and mannose metabolism -0.509565217 0.556324111 0 kegg kegg NA NA no no no no no no Notch signaling pathway Galactose metabolism 0 0 0.458429858 kegg kegg NA NA no no no no no no Notch signaling pathway Glutathione metabolism 0 0 -0.558301158 kegg kegg NA NA no no no no no no Notch signaling pathway Glycerolipid metabolism 0 0.596837945 0.78970399 kegg kegg NA NA no no no no no up Notch signaling pathway Glycerophospholipid metabolism 0.527826087 0.588932806 0.802316602 kegg kegg NA NA no no no no no up Notch signaling pathway "Glycine, serine and threonine metabolism" -0.439130435 0 -0.493693694 kegg kegg NA NA no no no no up no Notch signaling pathway Glycolysis / Gluconeogenesis -0.811304348 -0.669960474 0 kegg kegg NA NA no no no no no no Notch signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.692687747 0.466151866 kegg kegg NA NA no no no no no no Notch signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.701930502 kegg kegg NA NA no no no no no no Notch signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0.546956522 0 0.477477477 kegg kegg NA NA no no no no no no Notch signaling pathway Glycosaminoglycan degradation 0 0 0.614414414 kegg kegg NA NA no no no no no up Notch signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.786956522 0.444664032 0.445559846 kegg kegg NA NA no no no no no no Notch signaling pathway Glyoxylate and dicarboxylate metabolism 0 0 -0.438610039 kegg kegg NA NA no no no no no no Notch signaling pathway HIF-1 signaling pathway 0 -0.46541502 0 kegg kegg NA NA no no no no no no Notch signaling pathway Inositol phosphate metabolism 0 0.613636364 0.712226512 kegg kegg NA NA no no no no no no Notch signaling pathway Linoleic acid metabolism -0.470434783 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Longevity regulating pathway 0.412173913 0 -0.484169884 kegg kegg NA NA no no no no no no Notch signaling pathway Longevity regulating pathway - multiple species 0 -0.499011858 0 kegg kegg NA NA no no no no no no Notch signaling pathway Lysine degradation 0 0.5 0.764993565 kegg kegg NA NA no no no no no no Notch signaling pathway Lysosome 0.433043478 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Mannose type O-glycan biosynthesis 0.572173913 0.503952569 0.768854569 kegg kegg NA NA no no no no no no Notch signaling pathway MAPK signaling pathway 0 0 0.562676963 kegg kegg NA NA no no no no no no Notch signaling pathway Metabolism of xenobiotics by cytochrome P450 -0.690434783 -0.451581028 0 kegg kegg NA NA no no no no no no Notch signaling pathway Mismatch repair -0.423478261 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Mitophagy - animal 0 0 -0.53976834 kegg kegg NA NA no no no no no no Notch signaling pathway mRNA surveillance pathway 0.533913043 0 0.605148005 kegg kegg NA NA no no no no no no Notch signaling pathway Mucin type O-glycan biosynthesis -0.537391304 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway N-Glycan biosynthesis 0 0 0.433204633 kegg kegg NA NA no no no no no no Notch signaling pathway Necroptosis 0 0 -0.587644788 kegg kegg NA NA no no no no no no Notch signaling pathway NF-kappa B signaling pathway 0 0.561264822 0 kegg kegg NA NA no no no no no no Notch signaling pathway Nitrogen metabolism 0 0 -0.492664093 kegg kegg NA NA no no no no no no Notch signaling pathway Non-homologous end-joining -0.608695652 -0.557312253 0 kegg kegg NA NA no no no no no no Notch signaling pathway One carbon pool by folate 0 0 0.548005148 kegg kegg NA NA no no no no no no Notch signaling pathway Oocyte meiosis 0 -0.605731225 0 kegg kegg NA NA no no no no no no Notch signaling pathway Other glycan degradation 0 0.497035573 0.726640927 kegg kegg NA NA no no no no no no Notch signaling pathway Other types of O-glycan biosynthesis 0 0.491106719 0.726383526 kegg kegg NA NA no no no no no no Notch signaling pathway p53 signaling pathway 0 0.441699605 0 kegg kegg NA NA no no no no no no Notch signaling pathway Pentose and glucuronate interconversions -0.59826087 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Peroxisome 0 0 -0.518918919 kegg kegg NA NA no no no no no no Notch signaling pathway Phenylalanine metabolism -0.47826087 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Phosphatidylinositol signaling system 0.536521739 0 0.769369369 kegg kegg NA NA no no no no no no Notch signaling pathway Phospholipase D signaling pathway 0.484347826 0.630434783 0 kegg kegg NA NA no no no no up up Notch signaling pathway Platinum drug resistance 0 0.445652174 0 kegg kegg NA NA no no no no no no Notch signaling pathway Porphyrin and chlorophyll metabolism -0.470434783 0 -0.500900901 kegg kegg NA NA no no no no no no Notch signaling pathway Primary bile acid biosynthesis 0 -0.567193676 0 kegg kegg NA NA no no no no no no Notch signaling pathway Propanoate metabolism -0.637391304 -0.579051383 0 kegg kegg NA NA no no no no no no Notch signaling pathway Proteasome 0 -0.692687747 0 kegg kegg NA NA no no no no no no Notch signaling pathway Protein export 0 -0.468379447 0.410553411 kegg kegg NA NA no no no no no no Notch signaling pathway Purine metabolism 0 0 -0.441184041 kegg kegg NA NA no no no no no no Notch signaling pathway Pyrimidine metabolism 0 0 0.463577864 kegg kegg NA NA no no no no no no Notch signaling pathway Pyruvate metabolism -0.508695652 -0.524703557 0 kegg kegg NA NA no no no no no no Notch signaling pathway Ras signaling pathway 0 0 0.672586873 yes kegg kegg NA NA no no no no up up Notch signaling pathway Retinol metabolism -0.64 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Ribosome biogenesis in eukaryotes 0 0 0.561389961 kegg kegg NA NA no no no no no no Notch signaling pathway RNA degradation 0.52173913 0 0.648906049 kegg kegg NA NA no no no no no no Notch signaling pathway RNA polymerase 0 0 0.415701416 kegg kegg NA NA no no no no no no Notch signaling pathway RNA transport -0.503478261 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Selenocompound metabolism 0 0 0.6 kegg kegg NA NA no no no no no no Notch signaling pathway SNARE interactions in vesicular transport 0 0.440711462 0.416988417 kegg kegg NA NA no no no no no no Notch signaling pathway Sphingolipid metabolism 0 0 0.46048906 kegg kegg NA NA no no no no no no Notch signaling pathway Sphingolipid signaling pathway 0.54173913 0 0.547747748 kegg kegg NA NA no no no no no no Notch signaling pathway Steroid hormone biosynthesis -0.454782609 0 0.531016731 kegg kegg NA NA no no no no no no Notch signaling pathway Sulfur metabolism 0 0 -0.576319176 kegg kegg NA NA no no no no no no Notch signaling pathway Taurine and hypotaurine metabolism 0.414782609 0.731225296 0.531016731 kegg kegg NA NA no no no no no no Notch signaling pathway Terpenoid backbone biosynthesis 0 0 0.576576577 kegg kegg NA NA no no no no no no Notch signaling pathway Thiamine metabolism 0 -0.437747036 0 kegg kegg NA NA no no no no no no Notch signaling pathway Tryptophan metabolism -0.417391304 -0.475296443 0 kegg kegg NA NA no no no no up no Notch signaling pathway Tyrosine metabolism -0.590434783 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Ubiquitin mediated proteolysis 0 0 -0.52046332 kegg kegg NA NA no no no no no no Notch signaling pathway "Valine, leucine and isoleucine degradation" -0.446086957 0 0 kegg kegg NA NA no no no no no no Notch signaling pathway Various types of N-glycan biosynthesis 0 0 0.425997426 kegg kegg NA NA no no no no no no Notch signaling pathway Wnt signaling pathway 0.568695652 0 0.8002574 kegg kegg NA NA no no no no no no Nucleotide excision repair 2-Oxocarboxylic acid metabolism 0.442608696 0.664031621 0 kegg kegg NA NA no no no no no no Nucleotide excision repair ABC transporters 0.457391304 0 0 kegg kegg NA NA no no no no up up Nucleotide excision repair "Alanine, aspartate and glutamate metabolism" 0 -0.516798419 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Amino sugar and nucleotide sugar metabolism 0 0.493083004 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Aminoacyl-tRNA biosynthesis 0.705217391 0.764822134 0.633719434 kegg kegg NA NA no no no no no no Nucleotide excision repair Antifolate resistance 0.459130435 0.658102767 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Arginine and proline metabolism 0 -0.624505929 -0.472586873 kegg kegg NA NA no no no no up no Nucleotide excision repair Arginine biosynthesis 0 -0.564229249 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Ascorbate and aldarate metabolism 0.457391304 0.450592885 0.563963964 kegg kegg NA NA no no no no no no Nucleotide excision repair Basal transcription factors 0.692173913 0.781620553 0.814157014 kegg kegg NA NA no no no no no no Nucleotide excision repair Base excision repair 0.809565217 0.803359684 0.891634492 kegg kegg NA NA no no no no no no Nucleotide excision repair beta-Alanine metabolism 0 0.479249012 0.454826255 kegg kegg NA NA no no no no no no Nucleotide excision repair Biosynthesis of amino acids 0 -0.583003953 -0.480823681 kegg kegg NA NA no no no no no no Nucleotide excision repair Biosynthesis of cofactors 0 0.732213439 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Biosynthesis of unsaturated fatty acids 0.704347826 0.559288538 0.546203346 kegg kegg NA NA no no no no no no Nucleotide excision repair Butanoate metabolism 0.60173913 0.787549407 0.742084942 kegg kegg NA NA no no no no no no Nucleotide excision repair Citrate cycle (TCA cycle) 0.757391304 0.801383399 0.659459459 kegg kegg NA NA no no no no no no Nucleotide excision repair Cysteine and methionine metabolism 0.771304348 0.745059289 0.783783784 kegg kegg NA NA no no no no no no Nucleotide excision repair DNA replication 0.977391304 0.931818182 0.877992278 kegg kegg NA NA no no no no no no Nucleotide excision repair Drug metabolism - cytochrome P450 0 0.766798419 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Drug metabolism - other enzymes 0 0.58201581 0 kegg kegg NA NA no no no no no no Nucleotide excision repair EGFR tyrosine kinase inhibitor resistance 0 0 0.54028314 kegg kegg NA NA no no no no no no Nucleotide excision repair Ether lipid metabolism 0 0.604743083 0.634234234 kegg kegg NA NA no no no no no no Nucleotide excision repair Fatty acid biosynthesis 0 -0.554347826 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Fatty acid elongation 0.434782609 0 0.539253539 kegg kegg NA NA no no no no no no Nucleotide excision repair Folate biosynthesis 0.445217391 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Glutathione metabolism 0 0.48715415 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Glycerophospholipid metabolism 0 0 0.465122265 kegg kegg NA NA no no no no no up Nucleotide excision repair "Glycine, serine and threonine metabolism" 0 0.489130435 0 kegg kegg NA NA no no no no up no Nucleotide excision repair Glycolysis / Gluconeogenesis 0.407826087 0.425889328 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.569565217 -0.591897233 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.476284585 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Glycosaminoglycan degradation -0.656521739 -0.445652174 0 kegg kegg NA NA no no no no no up Nucleotide excision repair Glycosphingolipid biosynthesis - ganglio series 0 0.709486166 0.41956242 kegg kegg NA NA no no no no no no Nucleotide excision repair Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.544347826 0.511857708 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Glyoxylate and dicarboxylate metabolism 0 -0.591897233 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Inositol phosphate metabolism 0 0 0.496525097 kegg kegg NA NA no no no no no no Nucleotide excision repair Linoleic acid metabolism 0 0.43083004 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Lysine degradation 0 0 0.450965251 kegg kegg NA NA no no no no no no Nucleotide excision repair Metabolism of xenobiotics by cytochrome P450 0 0.713438735 0 kegg kegg NA NA no no no no no no Nucleotide excision repair mRNA surveillance pathway 0 0.481225296 0.466666667 kegg kegg NA NA no no no no no no Nucleotide excision repair Mucin type O-glycan biosynthesis 0.560869565 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair N-Glycan biosynthesis 0.642608696 0.732213439 0.631660232 kegg kegg NA NA no no no no no no Nucleotide excision repair Nicotinate and nicotinamide metabolism 0 -0.650197628 -0.513770914 kegg kegg NA NA no no no no no no Nucleotide excision repair Nitrogen metabolism -0.5 -0.585968379 -0.491377091 kegg kegg NA NA no no no no no no Nucleotide excision repair One carbon pool by folate 0.911304348 0.931818182 0.735392535 kegg kegg NA NA no no no no no no Nucleotide excision repair Other types of O-glycan biosynthesis 0.430434783 0.437747036 0.573487773 kegg kegg NA NA no no no no no no Nucleotide excision repair Pantothenate and CoA biosynthesis 0 -0.436758893 0 kegg kegg NA NA no no no no no dn Nucleotide excision repair Pentose and glucuronate interconversions 0.623478261 0.796442688 0.52998713 kegg kegg NA NA no no no no no no Nucleotide excision repair Pentose phosphate pathway -0.528695652 -0.666996047 -0.505534106 kegg kegg NA NA no no no no no no Nucleotide excision repair Phenylalanine metabolism 0 0.721343874 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Platinum drug resistance 0.583478261 0 0.618275418 kegg kegg NA NA no no no no no no Nucleotide excision repair Porphyrin and chlorophyll metabolism 0 0.419960474 0 kegg kegg NA NA no no no no no no Nucleotide excision repair PPAR signaling pathway 0 -0.704545455 -0.711454311 kegg kegg NA NA no no no no no no Nucleotide excision repair Primary bile acid biosynthesis 0.833043478 0.519762846 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Propanoate metabolism 0.732173913 0.679841897 0.758815959 kegg kegg NA NA no no no no no no Nucleotide excision repair Proteasome 0 0.499011858 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Protein export 0.559130435 0.513833992 0.44967825 kegg kegg NA NA no no no no no no Nucleotide excision repair Purine metabolism 0 0.494071146 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Pyrimidine metabolism 0.489565217 0.84486166 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Pyruvate metabolism 0.843478261 0.743083004 0.738738739 kegg kegg NA NA no no no no no no Nucleotide excision repair Retinol metabolism 0.605217391 0.853754941 0.708365508 kegg kegg NA NA no no no no no no Nucleotide excision repair Ribosome biogenesis in eukaryotes 0.782608696 0.874505929 0.776061776 kegg kegg NA NA no no no no no no Nucleotide excision repair RNA degradation 0 0.581027668 0.491634492 kegg kegg NA NA no no no no no no Nucleotide excision repair RNA polymerase 0.64173913 0.837944664 0.794079794 kegg kegg NA NA no no no no no no Nucleotide excision repair RNA transport 0.576521739 0 0.441698842 kegg kegg NA NA no no no no no no Nucleotide excision repair Selenocompound metabolism 0.526086957 0.609683794 0.711711712 kegg kegg NA NA no no no no no no Nucleotide excision repair Sphingolipid metabolism -0.644347826 0 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Spliceosome 0.650434783 0.414031621 0.604890605 kegg kegg NA NA no no no no no no Nucleotide excision repair Steroid biosynthesis 0.53826087 0.796442688 0.723552124 kegg kegg NA NA no no no no no no Nucleotide excision repair Steroid hormone biosynthesis 0.453913043 0.723320158 0.435778636 kegg kegg NA NA no no no no no no Nucleotide excision repair Sulfur metabolism 0 0.424901186 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Synthesis and degradation of ketone bodies 0.879130435 0.923913043 0.835521236 kegg kegg NA NA no no no no no no Nucleotide excision repair Terpenoid backbone biosynthesis 0.733913043 0.722332016 0.656885457 kegg kegg NA NA no no no no no no Nucleotide excision repair Thiamine metabolism 0.476521739 0.56916996 0 kegg kegg NA NA no no no no no no Nucleotide excision repair Tryptophan metabolism 0.644347826 0.648221344 0.596911197 kegg kegg NA NA no no no no up no Nucleotide excision repair Tyrosine metabolism 0.59826087 0.839920949 0.66975547 kegg kegg NA NA no no no no no no Nucleotide excision repair Ubiquinone and other terpenoid-quinone biosynthesis 0.720869565 0.904150198 0.827284427 kegg kegg NA NA no no no no no no Nucleotide excision repair "Valine, leucine and isoleucine degradation" 0.813043478 0.839920949 0.805662806 kegg kegg NA NA no no no no no no Nucleotide excision repair Various types of N-glycan biosynthesis 0.491304348 0.649209486 0.567052767 kegg kegg NA NA no no no no no no nutriCA+blood 12-ketoDCA+blood 0.54517823 0 0 serum_bileacids serum_bileacids 0.726 0.517 no no no no no no nutriCA+blood 14:0-LPC+blood 0.603450592 0 0 serum_bileacids serum_phospholipids 0.726 0.00689 no no no up up no nutriCA+blood 14:0/16:0-PC+blood 0 0 -0.401398568 serum_bileacids serum_phospholipids 0.726 0.0358 no no no no up no nutriCA+blood 14:1/18:2-PG+blood 0.472879412 0 0 serum_bileacids serum_phospholipids 0.726 0.00259 no no no no up up nutriCA+blood 16:0/16:0-PC+blood 0 -0.500563625 0 serum_bileacids serum_phospholipids 0.726 0.00079 no no no no up up nutriCA+blood 16:0/16:1-PI+blood 0.56992556 0 0 serum_bileacids serum_phospholipids 0.726 0.262 no no no no no no nutriCA+blood 16:0/18:1-PC+blood 0 0 -0.436121627 serum_bileacids serum_phospholipids 0.726 6.15E-07 no no no up up up nutriCA+blood 16:0/20:5-PG+blood -0.464057035 0 0 serum_bileacids serum_phospholipids 0.726 0.00656 no no no no up no nutriCA+blood 16:0/22:6-PC+blood -0.479937313 0 0 serum_bileacids serum_phospholipids 0.726 4.53E-05 no no no no up up nutriCA+blood 16:1/16:1-PC+blood -0.608744019 0 0 serum_bileacids serum_phospholipids 0.726 0.0177 no no no no no up nutriCA+blood 16:1/18:1-PG+blood -0.453470182 0 0 serum_bileacids serum_phospholipids 0.726 3.21E-05 no no no no up up nutriCA+blood 17-HDOHE+blood 0 -0.548529813 0 serum_bileacids serum_ARA 0.726 0.62 no no no no no no nutriCA+blood 18:0-LPC+blood 0 0.609238622 0 serum_bileacids serum_phospholipids 0.726 0.554 no no no no no no nutriCA+blood 18:0/16:0-PC+blood -0.478172838 0 -0.40047262 serum_bileacids serum_phospholipids 0.726 9.64E-07 no no no up up up nutriCA+blood 18:0/18:0-PC+blood -0.499346543 0 0 serum_bileacids serum_phospholipids 0.726 0.426 no no no no no no nutriCA+blood 18:0/18:1-PC+blood -0.464057035 0 0 serum_bileacids serum_phospholipids 0.726 0.393 no no no no no no nutriCA+blood 18:0/20:4-PC+blood -0.451705707 0 0 serum_bileacids serum_phospholipids 0.726 0.454 no no no no no no nutriCA+blood 18:0/20:4-PI+blood -0.538165002 0 0 serum_bileacids serum_phospholipids 0.726 0.167 no no no no no no nutriCA+blood 18:1/16:0-PI+blood 0 0 -0.404639387 serum_bileacids serum_phospholipids 0.726 0.793 no no no no no no nutriCA+blood 18:1/18:0-PS+blood -0.5311071 0 0 serum_bileacids serum_phospholipids 0.726 0.193 no no no no no no nutriCA+blood 18:1/18:1-PG+blood -0.460528084 0 0 serum_bileacids serum_phospholipids 0.726 0.00352 no no no no up up nutriCA+blood 18:1/20:3-PC+blood 0 0.53020226 0 serum_bileacids serum_phospholipids 0.726 0.00872 no no no no up up nutriCA+blood 18:1/20:4-PC+blood -0.568161084 0 0 serum_bileacids serum_phospholipids 0.726 0.582 no no no no no no nutriCA+blood 18:1/20:4-PE+blood -0.444647805 0 0 serum_bileacids serum_phospholipids 0.726 0.0578 no no no up no no nutriCA+blood 18:1/22:6-PE+blood -0.48523074 0 0 serum_bileacids serum_phospholipids 0.726 0.0047 no no no no up no nutriCA+blood 18:2-LPA+blood 0 -0.513736352 0 serum_bileacids serum_phospholipids 0.726 0.00684 no no no dn no up nutriCA+blood 18:2-LPE+blood 0.536400527 0 0 serum_bileacids serum_phospholipids 0.726 0.112 no no no no no no nutriCA+blood 18:3-LPC+blood 0.481701789 0 0 serum_bileacids serum_phospholipids 0.726 0.147 no no no no no no nutriCA+blood 18:3n3+blood -0.474643887 0 0 serum_bileacids serum_fattyacid 0.726 0.291 no no no no no no nutriCA+blood 20:0-LPC+blood 0 0.543374987 0 serum_bileacids serum_phospholipids 0.726 0.199 no no no no no no nutriCA+blood 20:0/20:5-PC+blood -0.682851986 0 0 serum_bileacids serum_phospholipids 0.726 0.882 no no no no no no nutriCA+blood 20:1-LPA+blood 0 -0.536788624 0 serum_bileacids serum_phospholipids 0.726 0.0187 no no no dn dn no nutriCA+blood 20:1-LPC+blood 0 0.490684079 0 serum_bileacids serum_phospholipids 0.726 0.217 no no no no no no nutriCA+blood 20:1/20:4-PE+blood -0.474643887 0 0 serum_bileacids serum_phospholipids 0.726 0.0042 no no no up up no nutriCA+blood 20:3-LPC+blood 0 0.628997713 0 serum_bileacids serum_phospholipids 0.726 0.0292 no no no no up no nutriCA+blood 20:3/18:0-PC+blood -0.492288641 0 0 serum_bileacids serum_phospholipids 0.726 0.296 no no no no no no nutriCA+blood 20:3/18:0-PI+blood -0.456999133 0 0 serum_bileacids serum_phospholipids 0.726 0.289 no no no no no no nutriCA+blood 20:4-LPA+blood 0 0 -0.449084903 serum_bileacids serum_phospholipids 0.726 0.398 no no no no no no nutriCA+blood 20:4/18:0-PE+blood -0.497582067 0 0 serum_bileacids serum_phospholipids 0.726 0.000755 no no no up up no nutriCA+blood 22:1-LPA+blood 0 0 -0.404639387 serum_bileacids serum_phospholipids 0.726 0.00373 no no no no up up nutriCA+blood 22:2-LPA+blood 0 0 -0.415287792 serum_bileacids serum_phospholipids 0.726 0.0443 no no no dn no no nutriCA+blood 4-hydroxybenzoic acid+stool 0 0 -0.525702993 serum_bileacids stool_cometabolism 0.726 0.0536 no no no no dn no nutriCA+blood acetic acid C2+blood -0.546987379 0 0 serum_bileacids serum_scfa 0.726 0.000193 no no no up dn no nutriCA+blood Adrenergic signaling in cardiomyocytes 0 0.569927284 0 serum_bileacids kegg 0.726 NA no no no no no up nutriCA+blood AGE-RAGE signaling pathway in diabetic complications 0 -0.558335543 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Aldosterone synthesis and secretion 0 0.624022078 0 serum_bileacids kegg 0.726 NA no no no no up up nutriCA+blood Alistipes 0 0.665630699 0 serum_bileacids Genus 0.726 0.0114 no no no no up no nutriCA+blood Alzheimer disease 0 0.533220103 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Amphetamine addiction 0 0.631749905 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood AMPK signaling pathway 0 0.533220103 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Amyotrophic lateral sclerosis 0 0.583450983 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Apelin signaling pathway 0.586888759 0.573791198 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Apoptosis 0 -0.608566422 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Arginine and proline metabolism -0.540107771 -0.562199457 0 serum_bileacids kegg 0.726 NA no no no no up no nutriCA+blood B cell receptor signaling pathway 0 -0.511968578 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Biosynthesis of amino acids 0 -0.575723155 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Biosynthesis of cofactors 0.461430655 0.546743802 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Bladder cancer 0 -0.59117881 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Blautia -0.483466264 0 0 acetate-producing serum_bileacids Genus 0.726 1.36E-05 no no no up dn dn nutriCA+blood C-type lectin receptor signaling pathway 0 -0.525492276 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood CA+blood 0.727237321 0 0.554690739 serum_bileacids serum_bileacids 0.726 0.606 no no no no no no nutriCA+blood CDCA+blood 0.78166261 0.71791362 0.635200502 serum_bileacids serum_bileacids 0.726 0.506 no no no no no no nutriCA+blood Cell adhesion molecules 0 -0.542879888 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Cell cycle 0 0.610498379 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood cGMP-PKG signaling pathway 0 -0.618226207 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Chemokine signaling pathway 0 -0.502308793 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Circadian entrainment 0 0 0.458853889 serum_bileacids kegg 0.726 NA no no no no up up nutriCA+blood Coronavirus disease - COVID-19 0.525222911 0.540947931 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Creatinine+blood -0.495817592 0 0 serum_bileacids serum_choline 0.726 0.437 no no no no no no nutriCA+blood Cushing syndrome 0 0.513900534 0 serum_bileacids kegg 0.726 NA no no no no no up nutriCA+blood d18:0-18:3-SM+blood 0 0 0.43982542 serum_bileacids serum_phospholipids 0.726 0.0879 no no no no dn no nutriCA+blood d18:1-18:0-SM+blood -0.504639969 0 0 serum_bileacids serum_phospholipids 0.726 0.97 no no no no no no nutriCA+blood d18:1-18:1-SM+blood -0.538165002 0 0 serum_bileacids serum_phospholipids 0.726 0.916 no no no no no no nutriCA+blood d18:1-20:1-SM+blood 0 0 0.51158641 serum_bileacids serum_phospholipids 0.726 0.0992 no no no no no no nutriCA+blood DCA+blood 0.61227297 0.540081806 0.480104169 serum_bileacids serum_bileacids 0.726 0.122 no no no no no no nutriCA+blood Diabetic cardiomyopathy 0 0.533220103 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood DPA+blood 0 -0.490684079 0 serum_bileacids serum_ARA 0.726 0.519 no no no no no no nutriCA+blood EGFR tyrosine kinase inhibitor resistance 0.637922564 0.569927284 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Endocrine and other factor-regulated calcium reabsorption 0 0 0.432164401 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Epithelial cell signaling in Helicobacter pylori infection 0 -0.606634466 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Fc epsilon RI signaling pathway 0 -0.61629425 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Fc gamma R-mediated phagocytosis -0.62941693 -0.595042724 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Gap junction 0 0 0.45782737 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Glucagon signaling pathway 0 0.720619922 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood "Glycine, serine and threonine metabolism" 0.486947557 0 0 serum_bileacids kegg 0.726 NA no no no no up no nutriCA+blood HCA+blood 0.790367034 0 0.554192222 serum_bileacids serum_bileacids 0.726 0.544 no no no no no no nutriCA+blood HIF-1 signaling pathway 0.561371857 0 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Huntington disease 0 0.533220103 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood IL-17 signaling pathway -0.459304246 -0.683912741 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Inflammatory bowel disease 0 -0.508104664 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Inflammatory mediator regulation of TRP channels 0 0.699368397 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Influenza A 0 -0.676184914 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Insulin secretion 0 0 0.401368838 yes serum_bileacids kegg 0.726 NA no no no no up up nutriCA+blood Insulin signaling pathway 0.550739814 0.627885991 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood isocapric acid iso-C6+blood -0.44641228 0 0 serum_bileacids serum_scfa 0.726 0.0458 no no no no no dn nutriCA+blood Kaposi sarcoma-associated herpesvirus infection 0.457177838 0 0 serum_bileacids kegg 0.726 NA no no no no no dn nutriCA+blood L-2-Aminobutyric acid+blood -0.638740101 0 0 yes serum_bileacids serum_aminoacids 0.726 0.000328 no no no up up no nutriCA+blood L-Lysine+blood -0.518755772 0 0 yes serum_bileacids serum_aminoacids 0.726 0.0107 no no no no up no nutriCA+blood L-Methionine+blood 0 0 -0.448621929 serum_bileacids serum_aminoacids 0.726 0.626 no no no no no no nutriCA+blood L-Tryptophan+stool -0.563720303 0 0 serum_bileacids stool_cometabolism 0.726 0.557 no no no no no no nutriCA+blood Lipid and atherosclerosis -0.610279253 -0.627885991 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Long-term potentiation 0 0.546743802 0 serum_bileacids kegg 0.726 NA no no no no no up nutriCA+blood Lysosome 0 -0.610498379 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Melanogenesis 0 0.666525129 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Mitophagy - animal 0.620911296 0 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Morphine addiction 0 0 0.418819657 serum_bileacids kegg 0.726 NA no no no no up up nutriCA+blood mRNA surveillance pathway 0 0.69743644 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood mTOR signaling pathway 0.678324327 0.569927284 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood MUFA%+blood -0.455234657 0 -0.431028912 serum_bileacids serum_fattyacid 0.726 0.00142 no no no up no dn nutriCA+blood Neutrophil extracellular trap formation -0.546486997 -0.610498379 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Nicotinate and nicotinamide metabolism 0 -0.64140969 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood NOD-like receptor signaling pathway -0.576256716 -0.539015974 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Olfactory transduction -0.595394393 -0.566063371 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Oocyte meiosis 0 0.52935619 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Osteoclast differentiation 0 -0.64140969 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Oxidative phosphorylation 0 0.533220103 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Pancreatic secretion 0 0 0.43319092 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Parkinson disease 0.493326783 0 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Pathogenic Escherichia coli infection 0 -0.506172707 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Pathways of neurodegeneration - multiple diseases 0.486947557 0.508104664 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Peroxisome -0.480568332 -0.579587069 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Pertussis -0.567751082 -0.566063371 0 serum_bileacids kegg 0.726 NA no no no no no dn nutriCA+blood Phagosome 0 -0.587314897 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood PI3K-Akt signaling pathway 0 0.537084017 0 yes serum_bileacids kegg 0.726 NA no no no no up up nutriCA+blood PPAR signaling pathway 0 -0.606634466 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Prion disease 0 0.533220103 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Prolactin signaling pathway 0 -0.566063371 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Protein processing in endoplasmic reticulum 0 0.670389043 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Proteoglycans in cancer 0.735737357 0.519696405 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Purine metabolism 0 0.61629425 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Ras signaling pathway 0 0.658797302 0 yes serum_bileacids kegg 0.726 NA no no no no up up nutriCA+blood Renin secretion 0 0.64140969 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Retrograde endocannabinoid signaling 0 0.521628362 0 serum_bileacids kegg 0.726 NA no no no no no up nutriCA+blood Rheumatoid arthritis 0 -0.738007534 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Ribosome 0.525222911 0.540947931 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Ribosome biogenesis in eukaryotes 0 0.519696405 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood RNA degradation 0 0.668457086 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood RNA transport 0.495453192 0.540947931 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Roseburia 0 0 0.404176413 butyrate-producing serum_bileacids Genus 0.726 0.495 no no no no no no nutriCA+blood Salmonella infection -0.459304246 0 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Shigellosis 0.623037704 0 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Spinocerebellar ataxia 0 0.564131414 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Staphylococcus aureus infection 0 -0.643341647 0 serum_bileacids kegg 0.726 NA no no no up no no nutriCA+blood Systemic lupus erythematosus 0 -0.651069474 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Thermogenesis 0 0.533220103 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Thyroid hormone synthesis 0 0 0.493755527 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Toll-like receptor signaling pathway 0 -0.633681862 0 yes serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Toxoplasmosis -0.625164113 0 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Tuberculosis -0.589015168 -0.668457086 0 serum_bileacids kegg 0.726 NA no no no no no dn nutriCA+blood Ubiquitin mediated proteolysis 0.620911296 0.533220103 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Vascular smooth muscle contraction 0.491200375 0.508104664 0.439350032 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Vasopressin-regulated water reabsorption 0 0 0.446535664 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Viral carcinogenesis 0 -0.500376836 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Wnt signaling pathway 0 0.680048828 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+blood Yersinia infection 0 -0.660729259 0 serum_bileacids kegg 0.726 NA no no no no no no nutriCA+stool 4-hydroxybenzoic acid+stool 0 0 0.446640316 stool_bileacids stool_cometabolism 0.481 0.0536 no no no no dn no nutriCA+stool 5-Hydroxytryptamine+stool 0 -0.732412528 0 stool_bileacids stool_cometabolism 0.481 0.00862 no no no dn dn no nutriCA+stool Adipocytokine signaling pathway 0 0 -0.512140034 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Alistipes 0 0.701949861 0 stool_bileacids Genus 0.481 0.0114 no no no no up no nutriCA+stool Alzheimer disease -0.481940144 0 0.655561829 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Amphetamine addiction -0.554179567 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool AMPK signaling pathway 0 0 -0.527950311 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Amyotrophic lateral sclerosis -0.531475748 0 0.68040655 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Bacteroides 0.649122807 0 0 LPS-producing stool_bileacids Genus 0.481 0.000267 no no no dn dn up nutriCA+stool Biosynthesis of amino acids 0.614035088 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool CA+stool 0.669762642 0.718327672 0.790513834 stool_bileacids stool_bileacids 0.481 0.827 no no no no no no nutriCA+stool Carbon metabolism 0.498452012 0.605530071 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Cardiac muscle contraction 0 0 0.62055336 stool_bileacids kegg 0.481 NA no no no no no up nutriCA+stool CDCA+stool 0.812177503 0.577479108 0.853754941 stool_bileacids stool_bileacids 0.481 0.663 no no no no no no nutriCA+stool Central carbon metabolism in cancer 0 0.688102353 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Chemical carcinogenesis - receptor activation -0.541795666 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Clostridium 0.589267286 0.91551566 0 stool_bileacids Genus 0.481 0.925 no no no no no no nutriCA+stool Coprococcus 0 0 -0.47826087 butyrate-producing stool_bileacids Genus 0.481 0.612 no no no no no no nutriCA+stool Coronavirus disease - COVID-19 -0.647058824 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Cushing syndrome -0.64499484 0 0 stool_bileacids kegg 0.481 NA no no no no no up nutriCA+stool Diabetic cardiomyopathy 0 0 0.611518916 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Eggerthella 0 0.655040468 0 stool_bileacids Genus 0.481 0.912 no no no no no no nutriCA+stool Endocrine resistance -0.601651187 0 -0.494071146 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Fc gamma R-mediated phagocytosis 0.64499484 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Ferroptosis 0 -0.623879467 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool FoxO signaling pathway 0 0 -0.422924901 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Fusobacterium 0 0 0.545064037 stool_bileacids Genus 0.481 0.628 no no no no no no nutriCA+stool GABAergic synapse 0.517027864 0 0 stool_bileacids kegg 0.481 NA no no no no up up nutriCA+stool Gap junction 0 -0.633054165 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool GCA+stool 0 0 0.422924901 stool_bileacids stool_bileacids 0.481 0.0809 no no no no no no nutriCA+stool Glutamatergic synapse 0 -0.614704769 0 stool_bileacids kegg 0.481 NA no no no no up up nutriCA+stool Glycolysis / Gluconeogenesis 0 0.761499938 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool "Growth hormone synthesis, secretion and action" -0.591331269 -0.678927655 -0.438735178 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool HCA+stool 0.845201238 0 0.556324111 stool_bileacids stool_bileacids 0.481 0.155 no no no no no no nutriCA+stool HDCA+stool -0.498452012 0 -0.434782609 stool_bileacids stool_bileacids 0.481 0.176 no no no no no no nutriCA+stool Hepatitis C 0 0 -0.549407115 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool HIF-1 signaling pathway 0 0.651403561 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Huntington disease -0.496388029 0 0.628458498 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool IL-17 signaling pathway 0.479876161 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Indole-3-Acetic acid+stool 0 -0.661988246 0 stool_bileacids stool_cometabolism 0.481 0.304 no no no no no no nutriCA+stool iso-DCA+stool -0.69246646 0 0 stool_bileacids stool_bileacids 0.481 0.155 no no no no no no nutriCA+stool iso-LCA+stool -0.726897361 0 -0.652173913 stool_bileacids stool_bileacids 0.481 0.72 no no no no no no nutriCA+stool Isobutyric acid+stool 0 -0.598606393 -0.527667984 stool_bileacids stool_scfa 0.481 0.408 no no no no no no nutriCA+stool Isovaleric acid+stool -0.473684211 0 -0.54743083 stool_bileacids stool_scfa 0.481 0.343 no no no no no no nutriCA+stool JAK-STAT signaling pathway 0 0 -0.524562394 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Kynurenic acid+stool -0.593395253 -0.676073103 -0.493083004 stool_bileacids stool_cometabolism 0.481 0.037 no no no dn dn no nutriCA+stool L-Phenylalanine+stool 0 0 -0.419960474 stool_bileacids stool_cometabolism 0.481 0.398 no no no no no no nutriCA+stool L-Tyrosine+stool 0 -0.626776106 -0.43083004 stool_bileacids stool_cometabolism 0.481 0.44 no no no no no no nutriCA+stool LCA+stool -0.490196078 0 -0.485177866 stool_bileacids stool_bileacids 0.481 0.314 no no no no no no nutriCA+stool Lipid and atherosclerosis 0.5500516 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Long-term potentiation 0 0 0.522303783 stool_bileacids kegg 0.481 NA no no no no no up nutriCA+stool Longevity regulating pathway 0 0 -0.446640316 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Mitophagy - animal -0.486068111 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Neutrophil extracellular trap formation 0.589267286 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool NOD-like receptor signaling pathway 0 0 -0.494071146 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Non-alcoholic fatty liver disease -0.471620227 0 0.507622812 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Olfactory transduction 0.564499484 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Oocyte meiosis 0 0.669752957 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Oscillospira -0.537667699 0 -0.517786561 LPS-producing stool_bileacids Genus 0.481 0.62 no no no no no no nutriCA+stool Osteoclast differentiation 0.475748194 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Oxidative phosphorylation 0 0 0.605872388 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool "Parathyroid hormone synthesis, secretion and action" -0.521155831 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Parkinson disease -0.539731682 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Pathways in cancer 0 0 -0.483907397 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Pathways of neurodegeneration - multiple diseases -0.539731682 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Peroxisome 0.59752322 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Pertussis 0.770897833 0 0 stool_bileacids kegg 0.481 NA no no no no no dn nutriCA+stool Phospholipase D signaling pathway 0 -0.669752957 0 stool_bileacids kegg 0.481 NA no no no no up up nutriCA+stool Prion disease 0 0 0.607001694 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Prolactin signaling pathway 0 0 -0.47826087 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Proteasome 0 0.623879467 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Proteoglycans in cancer 0 0 0.511010728 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Purine metabolism 0 0 -0.434217956 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Ras signaling pathway 0 0 0.445511011 yes stool_bileacids kegg 0.481 NA no no no no up up nutriCA+stool Regulation of actin cytoskeleton 0 0.633054165 0.617165443 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Retrograde endocannabinoid signaling 0 0 0.747035573 stool_bileacids kegg 0.481 NA no no no no no up nutriCA+stool Ribosome -0.657378741 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Ruminococcus 0.514105115 0 0 stool_bileacids Genus 0.481 0.0679 no no no no no dn nutriCA+stool Ruminococcus 0 0.633818534 0 acetate-producing stool_bileacids Genus 0.481 0.335 no no no no no no nutriCA+stool Salmonella infection 0.560371517 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Serotonergic synapse 0 -0.807373428 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Signaling pathways regulating pluripotency of stem cells -0.488132095 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Small cell lung cancer 0 0 -0.446640316 stool_bileacids kegg 0.481 NA no no no no no up nutriCA+stool Staphylococcus aureus infection 0.587203302 0 0 stool_bileacids kegg 0.481 NA no no no up no no nutriCA+stool Systemic lupus erythematosus 0.647058824 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Thermogenesis -0.562435501 0 0.578769057 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Tuberculosis 0.616099071 0 0 stool_bileacids kegg 0.481 NA no no no no no dn nutriCA+stool Ubiquitin mediated proteolysis -0.541795666 0 0 stool_bileacids kegg 0.481 NA no no no no no no nutriCA+stool Wnt signaling pathway 0 0 0.465838509 stool_bileacids kegg 0.481 NA no no no no no no octanoic acid C8+blood 11-HETE+blood 0 0 0.494823889 serum_mcfa serum_ARA 2.84E-11 0.464 dn dn dn no no no octanoic acid C8+blood 14:1/18:2-PG+blood 0 0.495098039 0 serum_mcfa serum_phospholipids 2.84E-11 0.00259 dn dn dn no up up octanoic acid C8+blood 16:0/20:3-PC+blood 0 0.571078431 0.548034188 serum_mcfa serum_phospholipids 2.84E-11 5.43E-06 dn dn dn no up up octanoic acid C8+blood 16:0/22:6-PC+blood 0 0 0.431111111 serum_mcfa serum_phospholipids 2.84E-11 4.53E-05 dn dn dn no up up octanoic acid C8+blood 16:1/18:1-PG+blood 0 0.605392157 0 serum_mcfa serum_phospholipids 2.84E-11 3.21E-05 dn dn dn no up up octanoic acid C8+blood 16:1/18:2-PG+blood 0 0.588235294 0 serum_mcfa serum_phospholipids 2.84E-11 1.40E-08 dn dn dn no up up octanoic acid C8+blood 18:0-LPA+blood 0 0.49754902 0 serum_mcfa serum_phospholipids 2.84E-11 0.0725 dn dn dn no dn no octanoic acid C8+blood 18:0-LPE+blood 0 0 -0.431794872 serum_mcfa serum_phospholipids 2.84E-11 0.491 dn dn dn no no no octanoic acid C8+blood 18:0/18:2-PC+blood 0 0 0.451623932 serum_mcfa serum_phospholipids 2.84E-11 1.74E-06 dn dn dn no up up octanoic acid C8+blood 18:0+blood 0.454135338 0 0 serum_mcfa serum_fattyacid 2.84E-11 0.344 dn dn dn no no no octanoic acid C8+blood 18:1/18:0-PC+blood 0 0 0.445470085 serum_mcfa serum_phospholipids 2.84E-11 1.83E-06 dn dn dn no up up octanoic acid C8+blood 18:1/18:1-PC+blood 0 0.634803922 0.567863248 serum_mcfa serum_phospholipids 2.84E-11 1.34E-05 dn dn dn no up up octanoic acid C8+blood 18:1/18:2-PG+blood 0 0.522058824 0 serum_mcfa serum_phospholipids 2.84E-11 5.58E-07 dn dn dn no up up octanoic acid C8+blood 18:2-LPE+blood 0 0.517156863 0 serum_mcfa serum_phospholipids 2.84E-11 0.112 dn dn dn no no no octanoic acid C8+blood 18:3/16:0-PE+blood -0.464661654 0 -0.410598291 serum_mcfa serum_phospholipids 2.84E-11 0.00149 dn dn dn up up no octanoic acid C8+blood 18:3n6+blood 0 0 -0.433162393 serum_mcfa serum_fattyacid 2.84E-11 0.0463 dn dn dn up no dn octanoic acid C8+blood 2-methyl-butyric acid m-C4+blood 0.526315789 0 0 serum_mcfa serum_scfa 2.84E-11 0.262 dn dn dn no no no octanoic acid C8+blood 20:0/20:4-PE+blood -0.508270677 0 0 serum_mcfa serum_phospholipids 2.84E-11 0.00128 dn dn dn up up no octanoic acid C8+blood 20:1-LPA+blood 0 0.642156863 0 serum_mcfa serum_phospholipids 2.84E-11 0.0187 dn dn dn dn dn no octanoic acid C8+blood 20:2-LPE+blood -0.560902256 0 0 serum_mcfa serum_phospholipids 2.84E-11 0.177 dn dn dn no no no octanoic acid C8+blood 20:2+blood 0 0.588235294 0 serum_mcfa serum_fattyacid 2.84E-11 0.478 dn dn dn no no no octanoic acid C8+blood 20:5-LPC+blood 0 -0.549019608 0 serum_mcfa serum_phospholipids 2.84E-11 0.558 dn dn dn no no no octanoic acid C8+blood 20:5/18:0-PC+blood 0 0 0.468717949 serum_mcfa serum_phospholipids 2.84E-11 3.97E-06 dn dn dn no up up octanoic acid C8+blood 22:1-LPA+blood 0 0.5 0 serum_mcfa serum_phospholipids 2.84E-11 0.00373 dn dn dn no up up octanoic acid C8+blood 22:2-LPA+blood 0 0.524509804 0 serum_mcfa serum_phospholipids 2.84E-11 0.0443 dn dn dn dn no no octanoic acid C8+blood 24:1+blood 0.529323308 0 0 serum_mcfa serum_fattyacid 2.84E-11 0.00582 dn dn dn no dn dn octanoic acid C8+blood 9-HODE+blood 0 0 -0.482393162 serum_mcfa serum_ARA 2.84E-11 0.297 dn dn dn no no no octanoic acid C8+blood acetic acid C2+blood 0.473684211 0 0 serum_mcfa serum_scfa 2.84E-11 0.000193 dn dn dn up dn no octanoic acid C8+blood butyric acid C4+blood 0.484210526 0 0 serum_mcfa serum_scfa 2.84E-11 0.407 dn dn dn no no no octanoic acid C8+blood capric acid C6+blood 0 0.558823529 0.52957265 serum_mcfa serum_scfa 2.84E-11 0.433 dn dn dn no no no octanoic acid C8+blood Cysteine+blood 0 0.536764706 0.496068376 yes serum_mcfa serum_aminoacids 2.84E-11 1.81E-07 dn dn dn dn up up octanoic acid C8+blood d18:0-16:0-SM+blood -0.446616541 0 0 serum_mcfa serum_phospholipids 2.84E-11 0.202 dn dn dn no no no octanoic acid C8+blood d18:1-16:0-SM+blood -0.484210526 0 0 serum_mcfa serum_phospholipids 2.84E-11 0.14 dn dn dn no no no octanoic acid C8+blood d18:1-20:0-SM+blood -0.470676692 0 0 serum_mcfa serum_phospholipids 2.84E-11 0.933 dn dn dn no no no octanoic acid C8+blood decanoic acid C10+blood 0.781954887 0.610294118 0.861880342 serum_mcfa serum_mcfa 2.84E-11 6.64E-11 dn dn dn dn dn no octanoic acid C8+blood heptanoic acid C7+blood 0.983458647 0.659313725 0 serum_mcfa serum_mcfa 2.84E-11 8.27E-11 dn dn dn dn dn no octanoic acid C8+blood iso-heptanoic acid C7+blood 0.454135338 0 0.624615385 serum_mcfa serum_mcfa 2.84E-11 0.00256 dn dn dn up up no octanoic acid C8+blood isobutyric acid C4+blood 0.512781955 0 0 serum_mcfa serum_scfa 2.84E-11 0.0151 dn dn dn up up no octanoic acid C8+blood L-Asparagine+blood 0.520300752 0 0.457777778 serum_mcfa serum_aminoacids 2.84E-11 0.784 dn dn dn no no no octanoic acid C8+blood L-Isoleucine+blood 0 0.50245098 0 yes serum_mcfa serum_aminoacids 2.84E-11 5.47E-06 dn dn dn up up no octanoic acid C8+blood L-Leucine+blood 0 0 0.448888889 yes serum_mcfa serum_aminoacids 2.84E-11 3.22E-05 dn dn dn up up no octanoic acid C8+blood L-Tryptophan+blood 0 0 0.578119658 serum_mcfa serum_aminoacids 2.84E-11 0.164 dn dn dn no no no octanoic acid C8+blood lauric acid C12+blood 0.505263158 0.693627451 0 serum_mcfa serum_mcfa 2.84E-11 0.015 dn dn dn no dn dn octanoic acid C8+blood n6/n3+blood 0 0.531862745 0 serum_mcfa serum_fattyacid 2.84E-11 0.226 dn dn dn no no no octanoic acid C8+blood nonanoic acid C9+blood 0.960902256 0.730392157 0 serum_mcfa serum_mcfa 2.84E-11 6.51E-11 dn dn dn dn dn no Olfactory transduction 2-Oxocarboxylic acid metabolism 0 -0.565217391 0 kegg kegg NA NA no no no no no no Olfactory transduction Adrenergic signaling in cardiomyocytes 0 -0.675889328 -0.552123552 kegg kegg NA NA no no no no no up Olfactory transduction "Alanine, aspartate and glutamate metabolism" 0.430434783 0.663043478 0.665379665 kegg kegg NA NA no no no no no no Olfactory transduction Alistipes -0.430571791 0 0 kegg Genus NA 0.0114 no no no no up no Olfactory transduction alpha-Linolenic acid metabolism 0 0.537549407 0 kegg kegg NA NA no no no no no no Olfactory transduction Aminoacyl-tRNA biosynthesis 0 0 -0.48983269 kegg kegg NA NA no no no no no no Olfactory transduction AMPK signaling pathway -0.655652174 -0.58201581 0 kegg kegg NA NA no no no no no no Olfactory transduction Antifolate resistance 0 -0.43083004 0 kegg kegg NA NA no no no no no no Olfactory transduction Apelin signaling pathway 0 -0.446640316 0 kegg kegg NA NA no no no no no no Olfactory transduction Apoptosis 0 0.479249012 0.573745174 kegg kegg NA NA no no no no no no Olfactory transduction Arginine and proline metabolism 0.586956522 0.682806324 0.535135135 kegg kegg NA NA no no no no up no Olfactory transduction Arginine biosynthesis 0.511304348 0.698616601 0.697039897 kegg kegg NA NA no no no no no no Olfactory transduction Basal transcription factors 0 -0.558300395 0 kegg kegg NA NA no no no no no no Olfactory transduction Base excision repair 0 -0.492094862 0 kegg kegg NA NA no no no no no no Olfactory transduction Biosynthesis of amino acids 0 0.815217391 0.789446589 kegg kegg NA NA no no no no no no Olfactory transduction Biosynthesis of cofactors -0.473913043 0 0 kegg kegg NA NA no no no no no no Olfactory transduction Calcium signaling pathway 0 -0.58201581 -0.661003861 kegg kegg NA NA no no no no up up Olfactory transduction Carbon metabolism 0 0.446640316 0.730759331 kegg kegg NA NA no no no no no no Olfactory transduction Cardiac muscle contraction 0 -0.599802372 0 kegg kegg NA NA no no no no no up Olfactory transduction Cell adhesion molecules 0 0.438735178 0 kegg kegg NA NA no no no no no no Olfactory transduction Cell cycle 0 -0.713438735 -0.626254826 kegg kegg NA NA no no no no no no Olfactory transduction cGMP-PKG signaling pathway 0.802608696 0.887351779 0.671299871 kegg kegg NA NA no no no no no no Olfactory transduction Chemokine signaling pathway 0 0.619565217 0 kegg kegg NA NA no no no no no no Olfactory transduction Circadian rhythm 0 -0.828063241 -0.564478764 kegg kegg NA NA no no no no no no Olfactory transduction Complement and coagulation cascades 0 0.816205534 0.518661519 kegg kegg NA NA no no no no no no Olfactory transduction Cytokine-cytokine receptor interaction 0.423478261 0.745059289 0 kegg kegg NA NA no no no no no no Olfactory transduction DNA replication 0 -0.545454545 0 kegg kegg NA NA no no no no no no Olfactory transduction Dopaminergic synapse 0 0 -0.480823681 kegg kegg NA NA no no no no up no Olfactory transduction ECM-receptor interaction -0.409565217 0 -0.425997426 kegg kegg NA NA no no no no up up Olfactory transduction EGFR tyrosine kinase inhibitor resistance -0.434782609 -0.43972332 0 kegg kegg NA NA no no no no no no Olfactory transduction Endocrine resistance 0 0 -0.411325611 kegg kegg NA NA no no no no no no Olfactory transduction Endocytosis 0 0.500988142 0 kegg kegg NA NA no no no no no no Olfactory transduction Ether lipid metabolism 0 -0.564229249 0 kegg kegg NA NA no no no no no no Olfactory transduction Fanconi anemia pathway 0 -0.460474308 -0.403346203 kegg kegg NA NA no no no no no no Olfactory transduction Fatty acid biosynthesis 0.588695652 0.71541502 0.590733591 kegg kegg NA NA no no no no no no Olfactory transduction Fatty acid degradation 0.513913043 0.590909091 0.606692407 kegg kegg NA NA no no no no no no Olfactory transduction Fatty acid metabolism 0.473913043 0.725296443 0.617245817 kegg kegg NA NA no no no no no no Olfactory transduction Fc epsilon RI signaling pathway 0 0.58201581 0.40952381 kegg kegg NA NA no no no no no no Olfactory transduction Fc gamma R-mediated phagocytosis 0.795652174 0.896245059 0.773230373 kegg kegg NA NA no no no no no no Olfactory transduction Folate biosynthesis 0 -0.666007905 0 kegg kegg NA NA no no no no no no Olfactory transduction FoxO signaling pathway 0.604347826 0 0 kegg kegg NA NA no no no no no no Olfactory transduction GABAergic synapse 0.530434783 0.623517787 0.582496782 kegg kegg NA NA no no no no up up Olfactory transduction Glutathione metabolism -0.482608696 -0.440711462 0 kegg kegg NA NA no no no no no no Olfactory transduction "Glycine, serine and threonine metabolism" -0.603478261 0 0 kegg kegg NA NA no no no no up no Olfactory transduction Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.5 0 kegg kegg NA NA no no no no no no Olfactory transduction Glycosaminoglycan biosynthesis - keratan sulfate 0 -0.690711462 -0.497554698 kegg kegg NA NA no no no no no no Olfactory transduction Glycosaminoglycan degradation 0 0.47826087 0 kegg kegg NA NA no no no no no up Olfactory transduction Glycosphingolipid biosynthesis - ganglio series 0 -0.481225296 0 kegg kegg NA NA no no no no no no Olfactory transduction Glyoxylate and dicarboxylate metabolism 0 0.717391304 0.704504505 kegg kegg NA NA no no no no no no Olfactory transduction Hedgehog signaling pathway 0 -0.584980237 -0.542342342 kegg kegg NA NA no no no no no no Olfactory transduction Hippo signaling pathway - multiple species 0.526956522 0.480237154 0 kegg kegg NA NA no no no no no no Olfactory transduction IL-17 signaling pathway 0.666956522 0.806324111 0.767567568 kegg kegg NA NA no no no no no no Olfactory transduction Intestinal immune network for IgA production -0.46 0 0 kegg kegg NA NA no no no no no no Olfactory transduction JAK-STAT signaling pathway 0.474782609 0 0 kegg kegg NA NA no no no no no no Olfactory transduction Leukocyte transendothelial migration 0 0 0.425482625 kegg kegg NA NA no no no no no no Olfactory transduction Longevity regulating pathway - multiple species 0.61826087 0 0 kegg kegg NA NA no no no no no no Olfactory transduction Lysine degradation -0.484347826 -0.668972332 -0.519433719 kegg kegg NA NA no no no no no no Olfactory transduction Lysosome 0.451304348 0.738142292 0.806435006 kegg kegg NA NA no no no no no no Olfactory transduction Mannose type O-glycan biosynthesis -0.463478261 -0.731225296 -0.524839125 kegg kegg NA NA no no no no no no Olfactory transduction MAPK signaling pathway 0.586086957 0 0 kegg kegg NA NA no no no no no no Olfactory transduction Mitophagy - animal -0.527826087 -0.497035573 0 kegg kegg NA NA no no no no no no Olfactory transduction mRNA surveillance pathway 0 -0.923913043 -0.628056628 kegg kegg NA NA no no no no no no Olfactory transduction mTOR signaling pathway -0.433913043 -0.447628458 0 kegg kegg NA NA no no no no no no Olfactory transduction N-Glycan biosynthesis 0 -0.716403162 -0.598970399 kegg kegg NA NA no no no no no no Olfactory transduction Natural killer cell mediated cytotoxicity 0 0.435770751 0 kegg kegg NA NA no no no no no no Olfactory transduction Neuroactive ligand-receptor interaction 0.705217391 0.764822134 0.81029601 kegg kegg NA NA no no no up up up Olfactory transduction Neutrophil extracellular trap formation 0.595652174 0.868577075 0.713256113 kegg kegg NA NA no no no no no no Olfactory transduction Nicotinate and nicotinamide metabolism 0.693043478 0.76284585 0.728957529 kegg kegg NA NA no no no no no no Olfactory transduction Nitrogen metabolism 0 0.659090909 0.542599743 kegg kegg NA NA no no no no no no Olfactory transduction NOD-like receptor signaling pathway 0.670434783 0.499011858 0 kegg kegg NA NA no no no no no no Olfactory transduction Nucleotide excision repair 0 -0.445652174 0 kegg kegg NA NA no no no no no no Olfactory transduction One carbon pool by folate 0 -0.470355731 -0.506048906 kegg kegg NA NA no no no no no no Olfactory transduction Osteoclast differentiation 0.629565217 0.723320158 0.669240669 kegg kegg NA NA no no no no no no Olfactory transduction Other types of O-glycan biosynthesis 0 -0.589920949 -0.471042471 kegg kegg NA NA no no no no no no Olfactory transduction Oxidative phosphorylation 0 -0.564229249 0 kegg kegg NA NA no no no no no no Olfactory transduction Pantothenate and CoA biosynthesis 0.852173913 0.81027668 0.812097812 kegg kegg NA NA no no no no no dn Olfactory transduction Paraprevotella 0 -0.457819866 0 kegg Genus NA 0.118 no no no no no no Olfactory transduction Pentose and glucuronate interconversions 0 -0.564229249 0 kegg kegg NA NA no no no no no no Olfactory transduction Pentose phosphate pathway 0 0.867588933 0.806177606 kegg kegg NA NA no no no no no no Olfactory transduction Peroxisome 0.660869565 0.725296443 0.64015444 kegg kegg NA NA no no no no no no Olfactory transduction Phagosome 0 0.635375494 0.40978121 kegg kegg NA NA no no no no no no Olfactory transduction Phosphatidylinositol signaling system 0 0 -0.461518662 kegg kegg NA NA no no no no no no Olfactory transduction Porphyrin and chlorophyll metabolism -0.532173913 0 0 kegg kegg NA NA no no no no no no Olfactory transduction PPAR signaling pathway 0 0.555335968 0.612870013 kegg kegg NA NA no no no no no no Olfactory transduction Primary bile acid biosynthesis 0 0 0.48030888 kegg kegg NA NA no no no no no no Olfactory transduction Protein export 0 -0.599802372 0 kegg kegg NA NA no no no no no no Olfactory transduction Protein processing in endoplasmic reticulum 0 -0.792490119 0 kegg kegg NA NA no no no no no no Olfactory transduction Purine metabolism -0.573043478 -0.463438735 0 kegg kegg NA NA no no no no no no Olfactory transduction Ras signaling pathway 0 -0.4743083 -0.415186615 yes kegg kegg NA NA no no no no up up Olfactory transduction Renin-angiotensin system 0.726086957 0.763833992 0.724324324 kegg kegg NA NA no no no no no no Olfactory transduction Retrograde endocannabinoid signaling 0 -0.434782609 0 kegg kegg NA NA no no no no no up Olfactory transduction Ribosome -0.497391304 -0.479249012 0 kegg kegg NA NA no no no no no no Olfactory transduction Ribosome biogenesis in eukaryotes 0 -0.650197628 -0.545173745 kegg kegg NA NA no no no no no no Olfactory transduction RNA degradation 0 -0.812252964 -0.566795367 kegg kegg NA NA no no no no no no Olfactory transduction RNA polymerase 0 -0.734189723 -0.46975547 kegg kegg NA NA no no no no no no Olfactory transduction RNA transport 0 -0.423913043 0 kegg kegg NA NA no no no no no no Olfactory transduction Ruminococcus -0.525217391 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Olfactory transduction Signaling pathways regulating pluripotency of stem cells 0 -0.583992095 -0.455083655 kegg kegg NA NA no no no no no no Olfactory transduction Spliceosome 0 -0.461462451 -0.473873874 kegg kegg NA NA no no no no no no Olfactory transduction Starch and sucrose metabolism 0.553913043 0.683794466 0.605920206 kegg kegg NA NA no no no no no no Olfactory transduction Synaptic vesicle cycle 0.717391304 0.942687747 0.697297297 kegg kegg NA NA no no no no up up Olfactory transduction TGF-beta signaling pathway 0 -0.43972332 0 kegg kegg NA NA no no no no no no Olfactory transduction Th1 and Th2 cell differentiation -0.416521739 0 0 kegg kegg NA NA no no no no no no Olfactory transduction Thermogenesis 0 -0.586956522 0 kegg kegg NA NA no no no no no no Olfactory transduction Toll-like receptor signaling pathway 0 0.530632411 0 yes kegg kegg NA NA no no no no no no Olfactory transduction Ubiquitin mediated proteolysis -0.614782609 -0.606719368 0 kegg kegg NA NA no no no no no no Olfactory transduction Various types of N-glycan biosynthesis 0 -0.660079051 -0.422908623 kegg kegg NA NA no no no no no no Olfactory transduction Viral protein interaction with cytokine and cytokine receptor 0 0.672924901 0 kegg kegg NA NA no no no no no no Olfactory transduction Wnt signaling pathway 0 -0.809288538 -0.516344916 kegg kegg NA NA no no no no no no One carbon pool by folate "Alanine, aspartate and glutamate metabolism" 0 -0.597826087 -0.503732304 kegg kegg NA NA no no no no no no One carbon pool by folate Amino sugar and nucleotide sugar metabolism 0 0.515810277 0 kegg kegg NA NA no no no no no no One carbon pool by folate Arginine and proline metabolism 0 -0.668972332 -0.50990991 kegg kegg NA NA no no no no up no One carbon pool by folate Arginine biosynthesis 0 -0.65513834 -0.637323037 kegg kegg NA NA no no no no no no One carbon pool by folate Ascorbate and aldarate metabolism 0.51826087 0.483201581 0.632689833 kegg kegg NA NA no no no no no no One carbon pool by folate beta-Alanine metabolism 0 0.448616601 0 kegg kegg NA NA no no no no no no One carbon pool by folate Butanoate metabolism 0.546956522 0.770750988 0.520720721 kegg kegg NA NA no no no no no no One carbon pool by folate Citrate cycle (TCA cycle) 0.732173913 0.7243083 0.695238095 kegg kegg NA NA no no no no no no One carbon pool by folate Cysteine and methionine metabolism 0.771304348 0.663043478 0.613127413 kegg kegg NA NA no no no no no no One carbon pool by folate Ether lipid metabolism 0 0.646245059 0.650707851 kegg kegg NA NA no no no no no no One carbon pool by folate Fatty acid biosynthesis 0 -0.578063241 0 kegg kegg NA NA no no no no no no One carbon pool by folate Glutathione metabolism 0 0.470355731 0 kegg kegg NA NA no no no no no no One carbon pool by folate Glycerolipid metabolism 0 0 0.617503218 kegg kegg NA NA no no no no no up One carbon pool by folate Glycerophospholipid metabolism 0 0 0.683912484 kegg kegg NA NA no no no no no up One carbon pool by folate "Glycine, serine and threonine metabolism" 0 0.495059289 0 kegg kegg NA NA no no no no up no One carbon pool by folate Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.545217391 -0.500988142 0 kegg kegg NA NA no no no no no no One carbon pool by folate Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.62055336 0.554182754 kegg kegg NA NA no no no no no no One carbon pool by folate Glycosaminoglycan degradation -0.706956522 -0.432806324 0 kegg kegg NA NA no no no no no up One carbon pool by folate Glycosphingolipid biosynthesis - ganglio series 0 0.704545455 0.546460746 kegg kegg NA NA no no no no no no One carbon pool by folate Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.619130435 0.503952569 0 kegg kegg NA NA no no no no no no One carbon pool by folate Glyoxylate and dicarboxylate metabolism 0 -0.686758893 -0.615958816 kegg kegg NA NA no no no no no no One carbon pool by folate Histidine metabolism 0.433913043 0 0 kegg kegg NA NA no no no no no no One carbon pool by folate Inositol phosphate metabolism 0.5 0 0.67953668 kegg kegg NA NA no no no no no no One carbon pool by folate Lysine degradation 0 0.43972332 0.664092664 kegg kegg NA NA no no no no no no One carbon pool by folate Mannose type O-glycan biosynthesis 0 0 0.621364221 kegg kegg NA NA no no no no no no One carbon pool by folate Mucin type O-glycan biosynthesis 0.484347826 0 0 kegg kegg NA NA no no no no no no One carbon pool by folate N-Glycan biosynthesis 0.62173913 0.793478261 0.766280566 kegg kegg NA NA no no no no no no One carbon pool by folate Other glycan degradation 0 0 0.545431145 kegg kegg NA NA no no no no no no One carbon pool by folate Other types of O-glycan biosynthesis 0.437391304 0.479249012 0.744401544 kegg kegg NA NA no no no no no no One carbon pool by folate Pentose and glucuronate interconversions 0.611304348 0.766798419 0.711454311 kegg kegg NA NA no no no no no no One carbon pool by folate Pentose phosphate pathway -0.512173913 -0.637351779 -0.581724582 kegg kegg NA NA no no no no no no One carbon pool by folate Phenylalanine metabolism 0 0.746047431 0.415701416 kegg kegg NA NA no no no no no no One carbon pool by folate Primary bile acid biosynthesis 0.783478261 0 0 kegg kegg NA NA no no no no no no One carbon pool by folate Propanoate metabolism 0.730434783 0.588932806 0.541312741 kegg kegg NA NA no no no no no no One carbon pool by folate Purine metabolism 0 0.527667984 0 kegg kegg NA NA no no no no no no One carbon pool by folate Pyrimidine metabolism 0 0.885375494 0 kegg kegg NA NA no no no no no no One carbon pool by folate Pyruvate metabolism 0.870434783 0.677865613 0.433719434 kegg kegg NA NA no no no no no no One carbon pool by folate Selenocompound metabolism 0.440869565 0.583003953 0.810553411 kegg kegg NA NA no no no no no no One carbon pool by folate Sphingolipid metabolism -0.680869565 0 0 kegg kegg NA NA no no no no no no One carbon pool by folate Starch and sucrose metabolism 0 -0.434782609 0 kegg kegg NA NA no no no no no no One carbon pool by folate Steroid biosynthesis 0.54173913 0.732213439 0.613384813 kegg kegg NA NA no no no no no no One carbon pool by folate Steroid hormone biosynthesis 0.457391304 0.752964427 0.567567568 kegg kegg NA NA no no no no no no One carbon pool by folate Synthesis and degradation of ketone bodies 0.868695652 0.864624506 0.659202059 kegg kegg NA NA no no no no no no One carbon pool by folate Taurine and hypotaurine metabolism 0 0 0.533075933 kegg kegg NA NA no no no no no no One carbon pool by folate Tryptophan metabolism 0.612173913 0.602766798 0 kegg kegg NA NA no no no no up no One carbon pool by folate Tyrosine metabolism 0.628695652 0.856719368 0 kegg kegg NA NA no no no no no no One carbon pool by folate Ubiquinone and other terpenoid-quinone biosynthesis 0.706086957 0.861660079 0.753410553 kegg kegg NA NA no no no no no no One carbon pool by folate "Valine, leucine and isoleucine degradation" 0.780869565 0.833003953 0.65019305 kegg kegg NA NA no no no no no no One carbon pool by folate Various types of N-glycan biosynthesis 0.412173913 0.698616601 0.691119691 kegg kegg NA NA no no no no no no Oocyte meiosis 2-Oxocarboxylic acid metabolism 0 0.523715415 0 kegg kegg NA NA no no no no no no Oocyte meiosis "Alanine, aspartate and glutamate metabolism" -0.406956522 -0.581027668 -0.436550837 kegg kegg NA NA no no no no no no Oocyte meiosis alpha-Linolenic acid metabolism 0 -0.446640316 0 kegg kegg NA NA no no no no no no Oocyte meiosis Aminoacyl-tRNA biosynthesis 0 0 0.412097812 kegg kegg NA NA no no no no no no Oocyte meiosis Arachidonic acid metabolism 0 0 -0.517374517 kegg kegg NA NA no no no no no no Oocyte meiosis Arginine and proline metabolism 0 -0.528656126 -0.451222651 kegg kegg NA NA no no no no up no Oocyte meiosis Arginine biosynthesis -0.46173913 -0.544466403 -0.527927928 kegg kegg NA NA no no no no no no Oocyte meiosis Bacteroides 0 0.482213439 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Oocyte meiosis Basal transcription factors 0.668695652 0.491106719 0.683140283 kegg kegg NA NA no no no no no no Oocyte meiosis Base excision repair 0.431304348 0 0.592020592 kegg kegg NA NA no no no no no no Oocyte meiosis beta-Alanine metabolism 0 0.545454545 0 kegg kegg NA NA no no no no no no Oocyte meiosis Biosynthesis of amino acids -0.52173913 0 -0.6 kegg kegg NA NA no no no no no no Oocyte meiosis Biosynthesis of cofactors 0 0 -0.41956242 kegg kegg NA NA no no no no no no Oocyte meiosis Biosynthesis of unsaturated fatty acids 0 0.62055336 0 kegg kegg NA NA no no no no no no Oocyte meiosis Butanoate metabolism 0 0.793478261 0 kegg kegg NA NA no no no no no no Oocyte meiosis cAMP signaling pathway 0 -0.64229249 0 yes kegg kegg NA NA no no no no up up Oocyte meiosis Carbon metabolism 0 0.457509881 -0.423166023 kegg kegg NA NA no no no no no no Oocyte meiosis Cell cycle 0.726956522 0.493083004 0.828828829 kegg kegg NA NA no no no no no no Oocyte meiosis Chemokine signaling pathway 0 -0.498023715 0 kegg kegg NA NA no no no no no no Oocyte meiosis Citrate cycle (TCA cycle) 0 0.833992095 0 kegg kegg NA NA no no no no no no Oocyte meiosis Clostridium 0 0.564418232 0 kegg Genus NA 0.925 no no no no no no Oocyte meiosis Cysteine and methionine metabolism 0.513043478 0.866600791 0.573487773 kegg kegg NA NA no no no no no no Oocyte meiosis DNA replication 0.531304348 0.681818182 0.526383526 kegg kegg NA NA no no no no no no Oocyte meiosis Drug metabolism - cytochrome P450 0 0.693675889 0 kegg kegg NA NA no no no no no no Oocyte meiosis Drug metabolism - other enzymes 0 0.731225296 0 kegg kegg NA NA no no no no no no Oocyte meiosis EGFR tyrosine kinase inhibitor resistance 0 0.598814229 0 kegg kegg NA NA no no no no no no Oocyte meiosis ErbB signaling pathway 0 -0.53458498 0 kegg kegg NA NA no no no no no no Oocyte meiosis Fanconi anemia pathway 0.473043478 0 0.646846847 kegg kegg NA NA no no no no no no Oocyte meiosis Fatty acid biosynthesis 0 -0.574110672 0 kegg kegg NA NA no no no no no no Oocyte meiosis Fatty acid elongation 0 0.690711462 0 kegg kegg NA NA no no no no no no Oocyte meiosis FoxO signaling pathway 0 -0.455533597 0 kegg kegg NA NA no no no no no no Oocyte meiosis Fructose and mannose metabolism -0.529565217 -0.670948617 -0.562419562 kegg kegg NA NA no no no no no no Oocyte meiosis Galactose metabolism -0.533043478 0 0 kegg kegg NA NA no no no no no no Oocyte meiosis Glutathione metabolism 0 0.446640316 0 kegg kegg NA NA no no no no no no Oocyte meiosis Glycerolipid metabolism -0.433913043 -0.537549407 0 kegg kegg NA NA no no no no no up Oocyte meiosis Glycerophospholipid metabolism 0 -0.420948617 0 kegg kegg NA NA no no no no no up Oocyte meiosis "Glycine, serine and threonine metabolism" 0 0 -0.452509653 kegg kegg NA NA no no no no up no Oocyte meiosis Glycolysis / Gluconeogenesis 0 0.757905138 0 kegg kegg NA NA no no no no no no Oocyte meiosis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.657391304 -0.825098814 0 kegg kegg NA NA no no no no no no Oocyte meiosis Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.4002574 kegg kegg NA NA no no no no no no Oocyte meiosis Glyoxylate and dicarboxylate metabolism -0.487826087 -0.52173913 -0.55984556 kegg kegg NA NA no no no no no no Oocyte meiosis HIF-1 signaling pathway 0 0.653162055 0 kegg kegg NA NA no no no no no no Oocyte meiosis Homologous recombination 0 0 0.632432432 kegg kegg NA NA no no no no no no Oocyte meiosis Lysine degradation 0 0 0.463063063 kegg kegg NA NA no no no no no no Oocyte meiosis Mannose type O-glycan biosynthesis 0 0 0.41956242 kegg kegg NA NA no no no no no no Oocyte meiosis Metabolism of xenobiotics by cytochrome P450 0 0.720355731 0 kegg kegg NA NA no no no no no no Oocyte meiosis Mismatch repair 0 0.727272727 0.498069498 kegg kegg NA NA no no no no no no Oocyte meiosis mRNA surveillance pathway 0.51826087 0 0.642213642 kegg kegg NA NA no no no no no no Oocyte meiosis Mucin type O-glycan biosynthesis 0.411304348 0 0 kegg kegg NA NA no no no no no no Oocyte meiosis N-Glycan biosynthesis 0.602608696 0.635375494 0.648648649 kegg kegg NA NA no no no no no no Oocyte meiosis Neuroactive ligand-receptor interaction 0 0 -0.422651223 kegg kegg NA NA no no no up up up Oocyte meiosis NF-kappa B signaling pathway 0 -0.750988142 0 kegg kegg NA NA no no no no no no Oocyte meiosis Nicotinate and nicotinamide metabolism 0 -0.635375494 -0.567310167 kegg kegg NA NA no no no no no no Oocyte meiosis Nitrogen metabolism -0.655652174 -0.543478261 -0.474646075 kegg kegg NA NA no no no no no no Oocyte meiosis Non-homologous end-joining 0 0.798418972 0 kegg kegg NA NA no no no no no no Oocyte meiosis Nucleotide excision repair 0.565217391 0.651185771 0.598712999 kegg kegg NA NA no no no no no no Oocyte meiosis One carbon pool by folate 0.467826087 0.5256917 0.462805663 kegg kegg NA NA no no no no no no Oocyte meiosis Other glycan degradation 0 -0.435770751 0 kegg kegg NA NA no no no no no no Oocyte meiosis Other types of O-glycan biosynthesis 0 0 0.536164736 kegg kegg NA NA no no no no no no Oocyte meiosis Oxidative phosphorylation 0.453913043 0.461462451 0 kegg kegg NA NA no no no no no no Oocyte meiosis Pantothenate and CoA biosynthesis 0 0 -0.467953668 kegg kegg NA NA no no no no no dn Oocyte meiosis Pentose and glucuronate interconversions 0 0.769762846 0.461003861 kegg kegg NA NA no no no no no no Oocyte meiosis Pentose phosphate pathway -0.711304348 0 -0.716602317 kegg kegg NA NA no no no no no no Oocyte meiosis Phenylalanine metabolism 0 0.618577075 0 kegg kegg NA NA no no no no no no Oocyte meiosis Phosphatidylinositol signaling system 0.591304348 0 0.642471042 kegg kegg NA NA no no no no no no Oocyte meiosis Phospholipase D signaling pathway -0.424347826 -0.871541502 0 kegg kegg NA NA no no no no up up Oocyte meiosis Platinum drug resistance 0 0 0.445559846 kegg kegg NA NA no no no no no no Oocyte meiosis Porphyrin and chlorophyll metabolism 0 0 -0.461776062 kegg kegg NA NA no no no no no no Oocyte meiosis PPAR signaling pathway 0 -0.447628458 -0.453796654 kegg kegg NA NA no no no no no no Oocyte meiosis Primary bile acid biosynthesis 0 0.798418972 0 kegg kegg NA NA no no no no no no Oocyte meiosis Propanoate metabolism 0 0.839920949 0.465637066 kegg kegg NA NA no no no no no no Oocyte meiosis Proteasome 0 0.803359684 0 kegg kegg NA NA no no no no no no Oocyte meiosis Protein export 0.808695652 0.778656126 0.635006435 kegg kegg NA NA no no no no no no Oocyte meiosis Pyrimidine metabolism 0 0.519762846 0 kegg kegg NA NA no no no no no no Oocyte meiosis Pyruvate metabolism 0 0.801383399 0 kegg kegg NA NA no no no no no no Oocyte meiosis Ras signaling pathway 0.584347826 0.694664032 0.689317889 yes kegg kegg NA NA no no no no up up Oocyte meiosis Retinol metabolism 0 0.48715415 0 kegg kegg NA NA no no no no no no Oocyte meiosis Ribosome 0.49826087 0.552371542 0 kegg kegg NA NA no no no no no no Oocyte meiosis Ribosome biogenesis in eukaryotes 0.557391304 0.436758893 0.722265122 kegg kegg NA NA no no no no no no Oocyte meiosis RNA degradation 0.515652174 0.532608696 0.693178893 kegg kegg NA NA no no no no no no Oocyte meiosis RNA polymerase 0.651304348 0.502964427 0.477734878 kegg kegg NA NA no no no no no no Oocyte meiosis RNA transport 0 0.632411067 0.422136422 kegg kegg NA NA no no no no no no Oocyte meiosis Spliceosome 0.447826087 0 0.720978121 kegg kegg NA NA no no no no no no Oocyte meiosis Starch and sucrose metabolism -0.475652174 -0.505928854 -0.473359073 kegg kegg NA NA no no no no no no Oocyte meiosis Steroid biosynthesis 0.672173913 0.717391304 0.471042471 kegg kegg NA NA no no no no no no Oocyte meiosis Steroid hormone biosynthesis 0 0.563241107 0 kegg kegg NA NA no no no no no no Oocyte meiosis Sulfur metabolism 0 0.415019763 -0.61003861 kegg kegg NA NA no no no no no no Oocyte meiosis Synthesis and degradation of ketone bodies 0.46 0.679841897 0.619305019 kegg kegg NA NA no no no no no no Oocyte meiosis Taurine and hypotaurine metabolism 0 -0.666996047 0 kegg kegg NA NA no no no no no no Oocyte meiosis Terpenoid backbone biosynthesis 0.690434783 0.584980237 0.601801802 kegg kegg NA NA no no no no no no Oocyte meiosis Thiamine metabolism 0 0.713438735 0 kegg kegg NA NA no no no no no no Oocyte meiosis Tryptophan metabolism 0 0.760869565 0 kegg kegg NA NA no no no no up no Oocyte meiosis Tyrosine metabolism 0 0.650197628 0 kegg kegg NA NA no no no no no no Oocyte meiosis Ubiquinone and other terpenoid-quinone biosynthesis 0 0.616600791 0 kegg kegg NA NA no no no no no no Oocyte meiosis "Valine, leucine and isoleucine degradation" 0 0.692687747 0.441956242 kegg kegg NA NA no no no no no no Oocyte meiosis Various types of N-glycan biosynthesis 0.577391304 0.609683794 0.629086229 kegg kegg NA NA no no no no no no Osteoclast differentiation 2-Oxocarboxylic acid metabolism 0 -0.616600791 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Adrenergic signaling in cardiomyocytes -0.490434783 -0.769762846 -0.451737452 kegg kegg NA NA no no no no no up Osteoclast differentiation "Alanine, aspartate and glutamate metabolism" 0.57826087 0.769762846 0.551608752 kegg kegg NA NA no no no no no no Osteoclast differentiation alpha-Linolenic acid metabolism 0.428695652 0.561264822 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Aminoacyl-tRNA biosynthesis 0 -0.483201581 -0.558558559 kegg kegg NA NA no no no no no no Osteoclast differentiation AMPK signaling pathway -0.548695652 -0.561264822 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Antifolate resistance 0 -0.510869565 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Apelin signaling pathway -0.424347826 -0.703557312 -0.488288288 kegg kegg NA NA no no no no no no Osteoclast differentiation Apoptosis 0.713043478 0.84486166 0.713256113 kegg kegg NA NA no no no no no no Osteoclast differentiation Arginine and proline metabolism 0.680869565 0.7756917 0.728442728 kegg kegg NA NA no no no no up no Osteoclast differentiation Arginine biosynthesis 0.665217391 0.77173913 0.640669241 kegg kegg NA NA no no no no no no Osteoclast differentiation Ascorbate and aldarate metabolism 0 -0.420948617 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Autophagy - animal 0 0.711462451 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Basal transcription factors 0 -0.559288538 -0.644787645 kegg kegg NA NA no no no no no no Osteoclast differentiation Base excision repair 0 -0.571146245 -0.740797941 kegg kegg NA NA no no no no no no Osteoclast differentiation Biosynthesis of amino acids 0.470434783 0.786561265 0.653796654 kegg kegg NA NA no no no no no no Osteoclast differentiation Biosynthesis of cofactors -0.5 -0.721343874 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Butanoate metabolism 0 -0.624505929 -0.557271557 kegg kegg NA NA no no no no no no Osteoclast differentiation Calcium signaling pathway -0.480869565 -0.541501976 0 kegg kegg NA NA no no no no up up Osteoclast differentiation Carbon metabolism 0 0 0.461261261 kegg kegg NA NA no no no no no no Osteoclast differentiation Cardiac muscle contraction 0 -0.696640316 -0.413899614 kegg kegg NA NA no no no no no up Osteoclast differentiation Cell cycle -0.42 -0.773715415 -0.741827542 kegg kegg NA NA no no no no no no Osteoclast differentiation Cellular senescence 0 0.701581028 0 kegg kegg NA NA no no no no no no Osteoclast differentiation cGMP-PKG signaling pathway 0.569565217 0.874505929 0.622136422 kegg kegg NA NA no no no no no no Osteoclast differentiation Chemokine signaling pathway 0 0.682806324 0.575289575 kegg kegg NA NA no no no no no no Osteoclast differentiation Citrate cycle (TCA cycle) 0 -0.633399209 -0.422651223 kegg kegg NA NA no no no no no no Osteoclast differentiation Cysteine and methionine metabolism 0 -0.592885375 -0.696267696 kegg kegg NA NA no no no no no no Osteoclast differentiation DNA replication 0 -0.785573123 -0.658429858 kegg kegg NA NA no no no no no no Osteoclast differentiation Drug metabolism - cytochrome P450 0 -0.77173913 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Drug metabolism - other enzymes 0 -0.669960474 0 kegg kegg NA NA no no no no no no Osteoclast differentiation EGFR tyrosine kinase inhibitor resistance 0 -0.588932806 -0.417760618 kegg kegg NA NA no no no no no no Osteoclast differentiation Endocrine resistance -0.57826087 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Endocytosis 0.423478261 0.688735178 0.413899614 kegg kegg NA NA no no no no no no Osteoclast differentiation Ether lipid metabolism 0 -0.618577075 -0.588931789 kegg kegg NA NA no no no no no no Osteoclast differentiation Fanconi anemia pathway 0 -0.510869565 -0.675160875 kegg kegg NA NA no no no no no no Osteoclast differentiation Fatty acid biosynthesis 0.579130435 0.83201581 0.631917632 kegg kegg NA NA no no no no no no Osteoclast differentiation Fatty acid degradation 0.466086957 0.622529644 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Fatty acid metabolism 0.472173913 0.633399209 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Folate biosynthesis 0 -0.506916996 0 kegg kegg NA NA no no no no no no Osteoclast differentiation FoxO signaling pathway 0 0.503952569 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Galactose metabolism 0 0.62944664 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Glutathione metabolism -0.5 -0.783596838 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Glycerolipid metabolism 0.464347826 0 0 kegg kegg NA NA no no no no no up Osteoclast differentiation "Glycine, serine and threonine metabolism" -0.548695652 -0.611660079 0 kegg kegg NA NA no no no no up no Osteoclast differentiation Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.695652174 0.652173913 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.475296443 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Glycosaminoglycan degradation 0.588695652 0.564229249 0 kegg kegg NA NA no no no no no up Osteoclast differentiation Glycosphingolipid biosynthesis - ganglio series 0 -0.510869565 -0.497554698 kegg kegg NA NA no no no no no no Osteoclast differentiation Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.442687747 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Glyoxylate and dicarboxylate metabolism 0.600869565 0.799407115 0.665122265 kegg kegg NA NA no no no no no no Osteoclast differentiation Hedgehog signaling pathway 0 -0.516798419 -0.467181467 kegg kegg NA NA no no no no no no Osteoclast differentiation HIF-1 signaling pathway 0 -0.504940711 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Homologous recombination 0 0 -0.687258687 kegg kegg NA NA no no no no no no Osteoclast differentiation Inositol phosphate metabolism 0 0 -0.423938224 kegg kegg NA NA no no no no no no Osteoclast differentiation Lysine degradation 0 0 -0.471042471 kegg kegg NA NA no no no no no no Osteoclast differentiation Lysosome 0.744347826 0.732213439 0.76010296 kegg kegg NA NA no no no no no no Osteoclast differentiation Mannose type O-glycan biosynthesis 0 0 -0.475160875 kegg kegg NA NA no no no no no no Osteoclast differentiation Metabolism of xenobiotics by cytochrome P450 0 -0.672924901 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Mismatch repair 0 -0.640316206 -0.574774775 kegg kegg NA NA no no no no no no Osteoclast differentiation Mitophagy - animal -0.494782609 -0.583992095 0 kegg kegg NA NA no no no no no no Osteoclast differentiation mRNA surveillance pathway 0 -0.763833992 -0.586357786 kegg kegg NA NA no no no no no no Osteoclast differentiation mTOR signaling pathway 0 -0.580039526 0 kegg kegg NA NA no no no no no no Osteoclast differentiation N-Glycan biosynthesis -0.553913043 -0.826086957 -0.686743887 kegg kegg NA NA no no no no no no Osteoclast differentiation Necroptosis -0.429565217 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Neuroactive ligand-receptor interaction 0.614782609 0.748023715 0.755469755 kegg kegg NA NA no no no up up up Osteoclast differentiation NF-kappa B signaling pathway 0.555652174 0.712450593 0.535649936 kegg kegg NA NA no no no no no no Osteoclast differentiation Nicotinate and nicotinamide metabolism 0.73826087 0.854743083 0.820592021 kegg kegg NA NA no no no no no no Osteoclast differentiation Nitrogen metabolism 0.606956522 0.687747036 0.619305019 kegg kegg NA NA no no no no no no Osteoclast differentiation Nucleotide excision repair 0 -0.735177866 -0.776576577 kegg kegg NA NA no no no no no no Osteoclast differentiation One carbon pool by folate -0.410434783 -0.747035573 -0.740540541 kegg kegg NA NA no no no no no no Osteoclast differentiation Oocyte meiosis -0.432173913 -0.4743083 -0.597425997 kegg kegg NA NA no no no no no no Osteoclast differentiation Other glycan degradation 0.426086957 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Other types of O-glycan biosynthesis 0 0 -0.553667954 kegg kegg NA NA no no no no no no Osteoclast differentiation Oxidative phosphorylation 0 -0.700592885 0 kegg kegg NA NA no no no no no no Osteoclast differentiation p53 signaling pathway 0 0 -0.481853282 kegg kegg NA NA no no no no no no Osteoclast differentiation Pantothenate and CoA biosynthesis 0.753913043 0.834980237 0.630888031 kegg kegg NA NA no no no no no dn Osteoclast differentiation Pentose and glucuronate interconversions 0 -0.730237154 -0.559330759 kegg kegg NA NA no no no no no no Osteoclast differentiation Pentose phosphate pathway 0.735652174 0.81916996 0.749034749 kegg kegg NA NA no no no no no no Osteoclast differentiation Peroxisome 0.599130435 0.764822134 0.453281853 kegg kegg NA NA no no no no no no Osteoclast differentiation Phagosome 0 0.72826087 0.537194337 kegg kegg NA NA no no no no no no Osteoclast differentiation Phenylalanine metabolism 0 -0.551383399 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Phosphatidylinositol signaling system 0 0 -0.500900901 kegg kegg NA NA no no no no no no Osteoclast differentiation Phospholipase D signaling pathway 0 0.543478261 0.403088803 kegg kegg NA NA no no no no up up Osteoclast differentiation PI3K-Akt signaling pathway 0 0 -0.44993565 yes kegg kegg NA NA no no no no up up Osteoclast differentiation Platinum drug resistance 0 0 -0.472586873 kegg kegg NA NA no no no no no no Osteoclast differentiation Porphyrin and chlorophyll metabolism -0.466956522 -0.571146245 0 kegg kegg NA NA no no no no no no Osteoclast differentiation PPAR signaling pathway 0.485217391 0.828063241 0.848906049 kegg kegg NA NA no no no no no no Osteoclast differentiation Propanoate metabolism 0 -0.537549407 -0.598970399 kegg kegg NA NA no no no no no no Osteoclast differentiation Proteasome 0 -0.422924901 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Protein export -0.56 -0.701581028 -0.52020592 kegg kegg NA NA no no no no no no Osteoclast differentiation Protein processing in endoplasmic reticulum -0.646956522 -0.880434783 -0.476190476 kegg kegg NA NA no no no no no no Osteoclast differentiation Purine metabolism -0.552173913 -0.640316206 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Pyrimidine metabolism 0 -0.721343874 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Pyruvate metabolism 0 -0.696640316 -0.598970399 kegg kegg NA NA no no no no no no Osteoclast differentiation Ras signaling pathway 0 -0.669960474 -0.461003861 yes kegg kegg NA NA no no no no up up Osteoclast differentiation Retinol metabolism 0 -0.496047431 -0.4002574 kegg kegg NA NA no no no no no no Osteoclast differentiation Ribosome -0.574782609 -0.65513834 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Ribosome biogenesis in eukaryotes -0.507826087 -0.673913043 -0.732303732 kegg kegg NA NA no no no no no no Osteoclast differentiation RNA degradation 0 -0.798418972 -0.567310167 kegg kegg NA NA no no no no no no Osteoclast differentiation RNA polymerase -0.551304348 -0.788537549 -0.732303732 kegg kegg NA NA no no no no no no Osteoclast differentiation RNA transport 0 -0.486166008 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Ruminococcus -0.63826087 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Osteoclast differentiation Sarcina 0 0.422326513 0 kegg Genus NA 0.0703 no no no no no no Osteoclast differentiation Selenocompound metabolism 0 0 -0.505534106 kegg kegg NA NA no no no no no no Osteoclast differentiation Sphingolipid metabolism 0.560869565 0 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Sphingolipid signaling pathway 0 0.673913043 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Spliceosome 0 0 -0.548519949 kegg kegg NA NA no no no no no no Osteoclast differentiation Starch and sucrose metabolism 0.764347826 0.794466403 0.454826255 kegg kegg NA NA no no no no no no Osteoclast differentiation Steroid biosynthesis -0.567826087 -0.45256917 -0.64967825 kegg kegg NA NA no no no no no no Osteoclast differentiation Steroid hormone biosynthesis 0 -0.435770751 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Synthesis and degradation of ketone bodies 0 -0.586956522 -0.610553411 kegg kegg NA NA no no no no no no Osteoclast differentiation Terpenoid backbone biosynthesis 0 0 -0.522007722 kegg kegg NA NA no no no no no no Osteoclast differentiation TGF-beta signaling pathway 0 -0.566205534 -0.407207207 kegg kegg NA NA no no no no no no Osteoclast differentiation Thiamine metabolism 0 -0.566205534 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Tyrosine metabolism 0 -0.64229249 -0.417245817 kegg kegg NA NA no no no no no no Osteoclast differentiation Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.598814229 -0.631145431 kegg kegg NA NA no no no no no no Osteoclast differentiation Ubiquitin mediated proteolysis -0.586086957 -0.712450593 0 kegg kegg NA NA no no no no no no Osteoclast differentiation "Valine, leucine and isoleucine degradation" 0 -0.632411067 -0.567824968 kegg kegg NA NA no no no no no no Osteoclast differentiation Various types of N-glycan biosynthesis 0 -0.660079051 -0.513513514 kegg kegg NA NA no no no no no no Osteoclast differentiation Vascular smooth muscle contraction -0.492173913 -0.651185771 0 kegg kegg NA NA no no no no no no Osteoclast differentiation VEGF signaling pathway 0 0.488142292 0 kegg kegg NA NA no no no no no no Osteoclast differentiation Wnt signaling pathway 0 -0.813241107 -0.462033462 kegg kegg NA NA no no no no no no Other glycan degradation Ascorbate and aldarate metabolism 0 0 0.675160875 kegg kegg NA NA no no no no no no Other glycan degradation Citrate cycle (TCA cycle) 0 0 0.436293436 kegg kegg NA NA no no no no no no Other glycan degradation Fructose and mannose metabolism 0.612173913 0.684782609 0.41956242 kegg kegg NA NA no no no no no no Other glycan degradation Galactose metabolism 0.564347826 0.524703557 0.677220077 kegg kegg NA NA no no no no no no Other glycan degradation Glutathione metabolism 0 -0.583992095 -0.53951094 kegg kegg NA NA no no no no no no Other glycan degradation "Glycine, serine and threonine metabolism" 0 0 -0.570913771 kegg kegg NA NA no no no no up no Other glycan degradation Glycolysis / Gluconeogenesis 0 -0.493083004 0 kegg kegg NA NA no no no no no no Other glycan degradation Histidine metabolism 0.457391304 0 0.413899614 kegg kegg NA NA no no no no no no Other glycan degradation Lysine degradation 0 0.668972332 0.694208494 kegg kegg NA NA no no no no no no Other glycan degradation Oxidative phosphorylation 0 -0.528656126 0 kegg kegg NA NA no no no no no no Other glycan degradation Pentose and glucuronate interconversions 0 0 0.500900901 kegg kegg NA NA no no no no no no Other glycan degradation Pentose phosphate pathway 0.412173913 0 0 kegg kegg NA NA no no no no no no Other glycan degradation Purine metabolism 0 0 -0.601801802 kegg kegg NA NA no no no no no no Other glycan degradation Pyrimidine metabolism 0 0 0.487258687 kegg kegg NA NA no no no no no no Other glycan degradation Selenocompound metabolism 0 0.536561265 0.658429858 kegg kegg NA NA no no no no no no Other glycan degradation Starch and sucrose metabolism 0.555652174 0 0.401544402 kegg kegg NA NA no no no no no no Other glycan degradation Steroid biosynthesis -0.442608696 0 0 kegg kegg NA NA no no no no no no Other glycan degradation Steroid hormone biosynthesis 0 0 0.428571429 kegg kegg NA NA no no no no no no Other glycan degradation Taurine and hypotaurine metabolism 0 0.678853755 0.519433719 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Arginine biosynthesis 0 0 -0.548005148 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Ascorbate and aldarate metabolism 0 0 0.505019305 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Citrate cycle (TCA cycle) 0 0 0.445302445 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Fatty acid elongation 0 -0.460474308 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Glutathione metabolism 0 0 -0.466409266 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Glycolysis / Gluconeogenesis 0 -0.414031621 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Lysine degradation 0.8 0.914031621 0.907593308 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Mucin type O-glycan biosynthesis 0 0.477272727 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis N-Glycan biosynthesis 0.584347826 0 0.697297297 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Other glycan degradation 0 0.570158103 0.653024453 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Pentose and glucuronate interconversions 0 0 0.434234234 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Pentose phosphate pathway -0.473913043 -0.690711462 -0.604890605 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Purine metabolism 0 0.434782609 0 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Pyrimidine metabolism 0 0 0.463320463 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Selenocompound metabolism 0.73826087 0.803359684 0.862805663 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Steroid biosynthesis 0 0 0.489060489 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Steroid hormone biosynthesis 0 0 0.506048906 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Synthesis and degradation of ketone bodies 0 0 0.527413127 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Taurine and hypotaurine metabolism 0.6 0.714426877 0.567567568 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis 0 0 0.508622909 kegg kegg NA NA no no no no no no Other types of O-glycan biosynthesis Various types of N-glycan biosynthesis 0.459130435 0.41798419 0.653281853 kegg kegg NA NA no no no no no no Ovarian steroidogenesis 2-Oxocarboxylic acid metabolism 0 0 -0.565765766 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Adrenergic signaling in cardiomyocytes 0.456521739 0.513833992 0 kegg kegg NA NA no up up no no up Ovarian steroidogenesis "Alanine, aspartate and glutamate metabolism" -0.484347826 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis alpha-Linolenic acid metabolism 0 0 -0.512741313 kegg kegg NA NA no up up no no no Ovarian steroidogenesis AMPK signaling pathway 0.449565217 0.418972332 0.54028314 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Antigen processing and presentation -0.496521739 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Arachidonic acid metabolism 0 0.579051383 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Arginine and proline metabolism -0.474782609 0 0 kegg kegg NA NA no up up no up no Ovarian steroidogenesis Arginine biosynthesis -0.469565217 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Ascorbate and aldarate metabolism 0 0 -0.674903475 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Autophagy - animal -0.411304348 0 -0.406692407 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Autophagy - other 0 0 -0.417245817 kegg kegg NA NA no up up no no no Ovarian steroidogenesis B cell receptor signaling pathway -0.513913043 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Basal transcription factors 0 0 -0.405405405 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Biosynthesis of cofactors 0.429565217 0 0.567567568 kegg kegg NA NA no up up no no no Ovarian steroidogenesis C-type lectin receptor signaling pathway -0.477391304 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Calcium signaling pathway 0 0.538537549 0 kegg kegg NA NA no up up no up up Ovarian steroidogenesis cAMP signaling pathway 0 0 0.537709138 yes kegg kegg NA NA no up up no up up Ovarian steroidogenesis Carbon metabolism 0 -0.591897233 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Cell adhesion molecules 0 -0.579051383 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Cholinergic synapse 0 0 -0.42985843 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Circadian entrainment 0.772173913 0.60770751 0.766023166 kegg kegg NA NA no up up no up up Ovarian steroidogenesis Citrate cycle (TCA cycle) 0 0 -0.605662806 kegg kegg NA NA no up up no no no Ovarian steroidogenesis DNA replication 0 0 -0.419047619 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Dopaminergic synapse 0.523478261 0.653162055 0.470785071 kegg kegg NA NA no up up no up no Ovarian steroidogenesis Drug metabolism - other enzymes 0 0 -0.574259974 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Endocrine resistance 0.732173913 0.756916996 0.713770914 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Endocytosis 0 -0.501976285 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Ether lipid metabolism 0 0 -0.404890605 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Fanconi anemia pathway 0 0 -0.412097812 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Fatty acid biosynthesis -0.505217391 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Fatty acid degradation -0.495652174 0 -0.402574003 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Fatty acid metabolism -0.466086957 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Fc gamma R-mediated phagocytosis -0.427826087 -0.441699605 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Ferroptosis 0.465217391 0.588932806 0.507078507 kegg kegg NA NA no up up no no no Ovarian steroidogenesis GABAergic synapse -0.43826087 0 0 kegg kegg NA NA no up up no up up Ovarian steroidogenesis Galactose metabolism 0 0 -0.639382239 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Gap junction 0.852173913 0.806324111 0.87001287 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Glutamatergic synapse 0.615652174 0.599802372 0.812870013 kegg kegg NA NA no up up no up up Ovarian steroidogenesis Glutathione metabolism 0 0.436758893 0.49009009 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Glycerolipid metabolism 0 0 -0.608494208 kegg kegg NA NA no up up no no up Ovarian steroidogenesis Glycerophospholipid metabolism 0 0 -0.571171171 kegg kegg NA NA no up up no no up Ovarian steroidogenesis "Glycine, serine and threonine metabolism" 0.467826087 0.451581028 0.575289575 kegg kegg NA NA no up up no up no Ovarian steroidogenesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.642213642 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Glycosaminoglycan degradation 0 0 -0.701415701 kegg kegg NA NA no up up no no up Ovarian steroidogenesis Glyoxylate and dicarboxylate metabolism -0.564347826 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis GnRH signaling pathway 0.610434783 0.742094862 0.623680824 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Hedgehog signaling pathway 0 0 -0.426512227 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Hematopoietic cell lineage 0 -0.483201581 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Hippo signaling pathway 0.464347826 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Hippo signaling pathway - multiple species -0.444347826 0 -0.510939511 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Histidine metabolism 0 0 -0.463320463 kegg kegg NA NA no up up no no no Ovarian steroidogenesis IL-17 signaling pathway -0.479130435 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Inflammatory mediator regulation of TRP channels 0.615652174 0.548418972 0.567567568 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Inositol phosphate metabolism 0 0 -0.50990991 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Insulin secretion 0.757391304 0.745059289 0.694723295 yes kegg kegg NA NA no up up no up up Ovarian steroidogenesis Insulin signaling pathway 0 0 -0.404633205 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Intestinal immune network for IgA production 0 -0.428853755 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Long-term depression 0.708695652 0.722332016 0.915057915 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Longevity regulating pathway 0 0 0.453024453 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Longevity regulating pathway - multiple species 0 -0.545454545 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Lysine degradation 0 0 -0.49034749 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Lysosome 0 -0.419960474 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Mannose type O-glycan biosynthesis 0 0 -0.472329472 kegg kegg NA NA no up up no no no Ovarian steroidogenesis MAPK signaling pathway 0 0 -0.576061776 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Mitophagy - animal 0.431304348 0.509881423 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Mucin type O-glycan biosynthesis 0 -0.449604743 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Natural killer cell mediated cytotoxicity 0 -0.425889328 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Necroptosis 0.539130435 0.593873518 0.530759331 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Neuroactive ligand-receptor interaction 0 -0.515810277 0 kegg kegg NA NA no up up up up up Ovarian steroidogenesis NF-kappa B signaling pathway -0.63826087 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Nicotinate and nicotinamide metabolism -0.559130435 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis NOD-like receptor signaling pathway -0.637391304 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Notch signaling pathway 0 0 -0.571171171 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Osteoclast differentiation -0.582608696 -0.420948617 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Other glycan degradation -0.491304348 0 -0.572972973 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Other types of O-glycan biosynthesis 0 0 -0.452252252 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Pentose and glucuronate interconversions 0 0 -0.464607465 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Peroxisome -0.60173913 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Phagosome 0 -0.464426877 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Phosphatidylinositol signaling system 0 0 -0.425997426 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Phospholipase D signaling pathway 0 0 0.441184041 kegg kegg NA NA no up up no up up Ovarian steroidogenesis Platelet activation 0.584347826 0 0.414414414 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Porphyrin and chlorophyll metabolism 0.448695652 0 0.555469755 kegg kegg NA NA no up up no no no Ovarian steroidogenesis PPAR signaling pathway -0.560869565 -0.462450593 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Proteasome -0.429565217 0 -0.557014157 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Purine metabolism 0 0.424901186 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Pyrimidine metabolism 0 0 -0.406949807 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Rap1 signaling pathway 0.413043478 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Renin-angiotensin system -0.433043478 -0.41798419 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Retinol metabolism 0 0 -0.555984556 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Ribosome biogenesis in eukaryotes 0 0 -0.402316602 kegg kegg NA NA no up up no no no Ovarian steroidogenesis RIG-I-like receptor signaling pathway -0.57826087 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis RNA degradation 0 0 -0.489060489 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Selenocompound metabolism 0 0 -0.512998713 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Serotonergic synapse 0.673043478 0.77173913 0.748262548 kegg kegg NA NA no up up no no no Ovarian steroidogenesis SNARE interactions in vesicular transport -0.545217391 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Sphingolipid metabolism 0 0 -0.52998713 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Sphingolipid signaling pathway 0 -0.515810277 -0.414157014 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Starch and sucrose metabolism 0 0 -0.493436293 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Steroid biosynthesis 0.42 0 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Steroid hormone biosynthesis 0 0 -0.6002574 kegg kegg NA NA no up up no no no Ovarian steroidogenesis T cell receptor signaling pathway 0 -0.437747036 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Taste transduction 0 0 -0.523037323 kegg kegg NA NA no up up no no up Ovarian steroidogenesis Terpenoid backbone biosynthesis 0 0 -0.525868726 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Th1 and Th2 cell differentiation 0 -0.553359684 -0.481595882 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Th17 cell differentiation 0 -0.605731225 -0.486743887 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Tryptophan metabolism 0 0 -0.55006435 kegg kegg NA NA no up up no up no Ovarian steroidogenesis Ubiquitin mediated proteolysis 0.473913043 0.505928854 0 kegg kegg NA NA no up up no no no Ovarian steroidogenesis "Valine, leucine and isoleucine degradation" 0 0 -0.402831403 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Vascular smooth muscle contraction 0.483478261 0.491106719 0.592792793 kegg kegg NA NA no up up no no no Ovarian steroidogenesis VEGF signaling pathway 0 0 -0.427799228 kegg kegg NA NA no up up no no no Ovarian steroidogenesis Wnt signaling pathway 0 0 -0.443758044 kegg kegg NA NA no up up no no no Oxidative phosphorylation Citrate cycle (TCA cycle) 0 0.416007905 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Fatty acid biosynthesis -0.415652174 -0.79743083 -0.546460746 kegg kegg NA NA no no no no no no Oxidative phosphorylation Fatty acid degradation -0.615652174 -0.860671937 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Fatty acid elongation -0.473913043 0 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Fructose and mannose metabolism -0.752173913 -0.598814229 -0.515830116 kegg kegg NA NA no no no no no no Oxidative phosphorylation Galactose metabolism -0.735652174 -0.756916996 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Glycolysis / Gluconeogenesis -0.59826087 0.448616601 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Oscillospira 0 -0.506916996 0 LPS-producing kegg Genus NA 0.62 no no no no no no Oxidative phosphorylation Pentose and glucuronate interconversions 0 0.527667984 0 kegg kegg NA NA no no no no no no Oxidative phosphorylation Pentose phosphate pathway -0.495652174 -0.526679842 -0.429343629 kegg kegg NA NA no no no no no no Oxytocin signaling pathway ABC transporters 0 -0.649209486 -0.476705277 kegg kegg NA NA no no no no up up Oxytocin signaling pathway Adherens junction 0.868695652 0.796442688 0.644272844 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Alistipes 0 -0.553245877 0 kegg Genus NA 0.0114 no no no no up no Oxytocin signaling pathway Aminoacyl-tRNA biosynthesis 0 0 -0.403088803 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Anaerostipes 0 -0.46243159 0 butyrate-producing kegg Genus NA 0.568 no no no no no no Oxytocin signaling pathway Apelin signaling pathway -0.471304348 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Apoptosis 0.48173913 0 0.433976834 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Apoptosis - multiple species -0.534782609 -0.693675889 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Arachidonic acid metabolism 0 0 0.543371943 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Autophagy - animal -0.61826087 -0.616600791 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Autophagy - other -0.839130435 -0.896245059 -0.67979408 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Basal transcription factors -0.685217391 -0.431818182 -0.593564994 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Base excision repair -0.565217391 -0.524703557 -0.402574003 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Biosynthesis of amino acids 0 0 0.552638353 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Butyricicoccus -0.554267084 0 0 butyrate-producing kegg Genus NA 0.852 no no no no no no Oxytocin signaling pathway C-type lectin receptor signaling pathway -0.509565217 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Carbon metabolism 0 0.445652174 0.511454311 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Cell cycle 0 0 -0.561132561 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Circadian entrainment 0.448695652 0.643280632 0.447619048 kegg kegg NA NA no no no no up up Oxytocin signaling pathway Circadian rhythm -0.555652174 -0.564229249 -0.752123552 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Complement and coagulation cascades 0 0 0.541055341 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Cytokine-cytokine receptor interaction 0 0 0.416731017 kegg kegg NA NA no no no no no no Oxytocin signaling pathway DNA replication 0 0 -0.458429858 kegg kegg NA NA no no no no no no Oxytocin signaling pathway EGFR tyrosine kinase inhibitor resistance -0.567826087 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway ErbB signaling pathway -0.434782609 -0.546442688 -0.443500644 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Estrogen signaling pathway 0 0 0.402059202 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Fanconi anemia pathway 0 -0.502964427 -0.500643501 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Fc gamma R-mediated phagocytosis 0 0 0.440669241 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Focal adhesion 0.90173913 0.743083004 0.554697555 kegg kegg NA NA no no no no up up Oxytocin signaling pathway Folate biosynthesis 0 0 -0.407722008 kegg kegg NA NA no no no no no no Oxytocin signaling pathway FoxO signaling pathway 0 -0.561264822 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Gap junction 0 0 0.552895753 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Glutathione metabolism 0 0 0.424967825 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Glycerolipid metabolism 0 -0.565217391 -0.572458172 kegg kegg NA NA no no no no no up Oxytocin signaling pathway Glycerophospholipid metabolism -0.473913043 -0.637351779 -0.618532819 kegg kegg NA NA no no no no no up Oxytocin signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.553043478 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0 0 -0.492406692 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Hedgehog signaling pathway 0 -0.460474308 -0.638095238 kegg kegg NA NA no no no no no no Oxytocin signaling pathway HIF-1 signaling pathway -0.631304348 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Hippo signaling pathway 0.824347826 0.635375494 0.501415701 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Homologous recombination 0 -0.639328063 -0.472072072 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Inositol phosphate metabolism 0 -0.649209486 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Insulin signaling pathway -0.565217391 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway JAK-STAT signaling pathway 0 -0.572134387 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Lachnospira 0 0.743760833 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Oxytocin signaling pathway Leukocyte transendothelial migration 0.762608696 0.708498024 0.699356499 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Linoleic acid metabolism 0 0 -0.425225225 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Long-term potentiation 0 0 -0.427541828 kegg kegg NA NA no no no no no up Oxytocin signaling pathway Lysine degradation -0.667826087 -0.71541502 -0.649163449 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Mannose type O-glycan biosynthesis 0 -0.586956522 -0.618275418 kegg kegg NA NA no no no no no no Oxytocin signaling pathway MAPK signaling pathway 0 -0.616600791 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway mRNA surveillance pathway -0.533913043 0 -0.58018018 kegg kegg NA NA no no no no no no Oxytocin signaling pathway mTOR signaling pathway -0.526086957 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Mucin type O-glycan biosynthesis 0 -0.755928854 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway N-Glycan biosynthesis 0 0 -0.426512227 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Neurotrophin signaling pathway -0.423478261 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Neutrophil extracellular trap formation 0.46 0 0.601801802 kegg kegg NA NA no no no no no no Oxytocin signaling pathway NF-kappa B signaling pathway -0.460869565 -0.520750988 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Notch signaling pathway 0 0 -0.542342342 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Other glycan degradation 0 -0.564229249 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Other types of O-glycan biosynthesis -0.624347826 -0.671936759 -0.640926641 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Ovarian steroidogenesis 0.446086957 0 0.433976834 kegg kegg NA NA no no no no up up Oxytocin signaling pathway p53 signaling pathway -0.673043478 -0.650197628 -0.605405405 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Pentose phosphate pathway 0 0 0.463835264 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Phagosome 0.479130435 0 0.512226512 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Phenylalanine metabolism 0.615652174 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Phosphatidylinositol signaling system 0 0 -0.56988417 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Phototransduction 0 0.508893281 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Platelet activation 0.931304348 0.850790514 0.736936937 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Platinum drug resistance -0.569565217 -0.741106719 -0.412612613 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Primary bile acid biosynthesis 0 0 0.447361647 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Progesterone-mediated oocyte maturation -0.515652174 -0.719367589 -0.578120978 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Proteasome -0.546086957 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Protein export -0.546956522 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Pyrimidine metabolism 0 0 -0.563706564 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Rap1 signaling pathway 0.84173913 0.87944664 0.703732304 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Ras signaling pathway 0 0 -0.493178893 yes kegg kegg NA NA no no no no up up Oxytocin signaling pathway Regulation of actin cytoskeleton 0.685217391 0.57312253 0.468211068 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Retrograde endocannabinoid signaling 0 0.445652174 0 kegg kegg NA NA no no no no no up Oxytocin signaling pathway Ribosome biogenesis in eukaryotes -0.570434783 0 -0.58996139 kegg kegg NA NA no no no no no no Oxytocin signaling pathway RIG-I-like receptor signaling pathway -0.61826087 -0.546442688 -0.42960103 kegg kegg NA NA no no no no no no Oxytocin signaling pathway RNA degradation -0.52173913 0 -0.64967825 kegg kegg NA NA no no no no no no Oxytocin signaling pathway RNA polymerase -0.677391304 0 -0.435778636 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Selenocompound metabolism -0.659130435 -0.643280632 -0.566023166 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Serotonergic synapse 0.407826087 0 0.577348777 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Signaling pathways regulating pluripotency of stem cells 0 -0.714426877 -0.584298584 kegg kegg NA NA no no no no no no Oxytocin signaling pathway SNARE interactions in vesicular transport 0 -0.622529644 -0.464092664 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Spliceosome -0.733913043 -0.834980237 -0.566280566 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Sulfur metabolism 0.440869565 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway T cell receptor signaling pathway 0 -0.749011858 -0.503217503 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Taste transduction 0 0 -0.553667954 kegg kegg NA NA no no no no no up Oxytocin signaling pathway Taurine and hypotaurine metabolism 0 -0.62055336 -0.585328185 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Terpenoid backbone biosynthesis 0 0 -0.497554698 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Thyroid hormone signaling pathway 0.77826087 0.646245059 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Tight junction 0.788695652 0.78458498 0.800514801 kegg kegg NA NA no no no no no no Oxytocin signaling pathway TNF signaling pathway -0.486956522 -0.445652174 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Tyrosine metabolism 0.442608696 0 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Various types of N-glycan biosynthesis 0 0 -0.45971686 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Vascular smooth muscle contraction 0 0.586956522 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Viral protein interaction with cytokine and cytokine receptor 0 0.506916996 0 kegg kegg NA NA no no no no no no Oxytocin signaling pathway Wnt signaling pathway 0 0 -0.545945946 kegg kegg NA NA no no no no no no P-hydroxyhippuric acid+urine 14:0/18:2-PC+blood 0.541666667 0 0 urine_cometabolism serum_phospholipids 0.436 0.102 no no no no up no P-hydroxyhippuric acid+urine 14:0/20:4-PC+blood 0 0 0.471428571 urine_cometabolism serum_phospholipids 0.436 0.486 no no no no no no P-hydroxyhippuric acid+urine 16:0/16:0-PC+blood 0 -0.67032967 0 urine_cometabolism serum_phospholipids 0.436 0.00079 no no no no up up P-hydroxyhippuric acid+urine 16:0/18:0-PC+blood 0 -0.582417582 0 urine_cometabolism serum_phospholipids 0.436 0.521 no no no no no no P-hydroxyhippuric acid+urine 16:0/18:0-PS+blood 0 -0.626373626 0 urine_cometabolism serum_phospholipids 0.436 0.377 no no no no no no P-hydroxyhippuric acid+urine 16:0/18:1-PC+blood 0 0 -0.494805195 urine_cometabolism serum_phospholipids 0.436 6.15E-07 no no no up up up P-hydroxyhippuric acid+urine 16:0/18:2-PC+blood 0 0 -0.544155844 urine_cometabolism serum_phospholipids 0.436 3.24E-06 no no no no up up P-hydroxyhippuric acid+urine 16:0/18:2-PI+blood 0.610294118 0 0 urine_cometabolism serum_phospholipids 0.436 0.269 no no no no no no P-hydroxyhippuric acid+urine 16:0/18:3-PC+blood 0.56127451 0 0 urine_cometabolism serum_phospholipids 0.436 0.00216 no no no no up up P-hydroxyhippuric acid+urine 16:0/22:6-PC+blood 0 0 -0.67012987 urine_cometabolism serum_phospholipids 0.436 4.53E-05 no no no no up up P-hydroxyhippuric acid+urine 16:0+blood 0 -0.642857143 0 yes urine_cometabolism serum_fattyacid 0.436 0.00876 no no no up no no P-hydroxyhippuric acid+urine 16:1/16:0-PC+blood 0 0 -0.55974026 urine_cometabolism serum_phospholipids 0.436 0.0215 no no no no up up P-hydroxyhippuric acid+urine 18:0/16:0-PC+blood 0 0 -0.479220779 urine_cometabolism serum_phospholipids 0.436 9.64E-07 no no no up up up P-hydroxyhippuric acid+urine 18:0/18:2-PI+blood 0 -0.604395604 0 urine_cometabolism serum_phospholipids 0.436 0.179 no no no no no no P-hydroxyhippuric acid+urine 18:0/20:3-PC+blood 0.588235294 0 0 urine_cometabolism serum_phospholipids 0.436 0.0682 no no no no up no P-hydroxyhippuric acid+urine 18:0/20:4-PI+blood 0 -0.626373626 -0.602597403 urine_cometabolism serum_phospholipids 0.436 0.167 no no no no no no P-hydroxyhippuric acid+urine 18:0/22:6-PA+blood 0 -0.791208791 0 urine_cometabolism serum_phospholipids 0.436 0.22 no no no no no no P-hydroxyhippuric acid+urine 18:0/22:6-PC+blood 0 0 -0.649350649 urine_cometabolism serum_phospholipids 0.436 0.0775 no no no no no up P-hydroxyhippuric acid+urine 18:1-LPE+blood 0 0 0.446753247 urine_cometabolism serum_phospholipids 0.436 0.117 no no no no no no P-hydroxyhippuric acid+urine 18:1/16:0-PC+blood 0 0 -0.525974026 urine_cometabolism serum_phospholipids 0.436 2.43E-05 no no no no up up P-hydroxyhippuric acid+urine 18:1/18:2-PG+blood 0 -0.604395604 0 urine_cometabolism serum_phospholipids 0.436 5.58E-07 no no no no up up P-hydroxyhippuric acid+urine 18:3n6+blood 0 0 0.537662338 urine_cometabolism serum_fattyacid 0.436 0.0463 no no no up no dn P-hydroxyhippuric acid+urine 2-hydroxyphenylacetic acid+urine 0 0 0.619145299 urine_cometabolism urine_cometabolism 0.436 0.763 no no no no no no P-hydroxyhippuric acid+urine 20:2/18:0-PC+blood 0.595588235 0 0 urine_cometabolism serum_phospholipids 0.436 0.0427 no no no no up no P-hydroxyhippuric acid+urine 20:3/16:0-PC+blood -0.50245098 0 0 urine_cometabolism serum_phospholipids 0.436 0.00405 no no no no up up P-hydroxyhippuric acid+urine 20:5/18:0-PC+blood 0 0 -0.479220779 urine_cometabolism serum_phospholipids 0.436 3.97E-06 no no no no up up P-hydroxyhippuric acid+urine 22:6n3+blood 0.56127451 0 -0.594805195 urine_cometabolism serum_fattyacid 0.436 0.792 no no no no no no P-hydroxyhippuric acid+urine 24:0+blood 0 -0.604395604 0 urine_cometabolism serum_fattyacid 0.436 0.034 no no no dn no up P-hydroxyhippuric acid+urine 3-(3-Hydroxyphenyl)propanoic acid+stool 0.569230769 0 0 urine_cometabolism stool_cometabolism 0.436 0.33 no no no no no no P-hydroxyhippuric acid+urine "3-(3,4-dihydroxyphenyl)propionic acid+urine" 0.545864662 0 0 urine_cometabolism urine_cometabolism 0.436 0.0125 no no no up up no P-hydroxyhippuric acid+urine 3-Hydroxytyramine hydrochloride+urine 0 0 -0.504273504 urine_cometabolism urine_cometabolism 0.436 0.288 no no no no no no P-hydroxyhippuric acid+urine 4-hydroxybenzoic acid+urine 0 0 0.628034188 urine_cometabolism urine_cometabolism 0.436 0.52 no no no no no no P-hydroxyhippuric acid+urine 4-Hydroxyphenylacetic acid+urine 0 0 0.582222222 urine_cometabolism urine_cometabolism 0.436 0.0321 no no no up up no P-hydroxyhippuric acid+urine 5-Hydroxyindole-3-acetic Acid+urine 0 0 -0.409230769 urine_cometabolism urine_cometabolism 0.436 0.0405 no no no no dn dn P-hydroxyhippuric acid+urine ACA+blood -0.495562179 0 0 urine_cometabolism serum_bileacids 0.436 0.338 no no no no no no P-hydroxyhippuric acid+urine Acetic acid+stool 0 0.683333333 0 yes urine_cometabolism stool_scfa 0.436 0.0656 no no no dn no no P-hydroxyhippuric acid+urine Adrenergic signaling in cardiomyocytes -0.49122807 0.635087719 0 urine_cometabolism kegg 0.436 NA no no no no no up P-hydroxyhippuric acid+urine Akkermansia 0 0.466229237 0 acetate-producing urine_cometabolism Genus 0.436 0.23 no no no no no no P-hydroxyhippuric acid+urine Alcoholism 0 0 0.460769231 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Aldosterone synthesis and secretion 0 0.477192982 0 urine_cometabolism kegg 0.436 NA no no no no up up P-hydroxyhippuric acid+urine Alzheimer disease -0.638596491 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Amphetamine addiction 0 0 0.513846154 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Amyotrophic lateral sclerosis -0.696491228 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Arachidonic acid metabolism 0 0 0.564615385 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Arrhythmogenic right ventricular cardiomyopathy 0 0 0.404615385 urine_cometabolism kegg 0.436 NA no no no no up up P-hydroxyhippuric acid+urine Autophagy - animal 0 0 -0.434615385 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Bacteroides 0.643609023 0 0 LPS-producing urine_cometabolism Genus 0.436 0.000267 no no no dn dn up P-hydroxyhippuric acid+urine Biosynthesis of amino acids 0.496491228 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Biosynthesis of cofactors 0 0 0.400769231 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Blautia 0.455639098 0 0 acetate-producing urine_cometabolism Genus 0.436 1.36E-05 no no no up dn dn P-hydroxyhippuric acid+urine Butyric acid+stool 0 0.716666667 0 yes urine_cometabolism stool_scfa 0.436 0.102 no no no dn no no P-hydroxyhippuric acid+urine CA+stool 0 0 0.704850361 urine_cometabolism stool_bileacids 0.436 0.827 no no no no no no P-hydroxyhippuric acid+urine Calcium signaling pathway 0 0.48245614 0 urine_cometabolism kegg 0.436 NA no no no no up up P-hydroxyhippuric acid+urine cAMP signaling pathway -0.578947368 0 0 yes urine_cometabolism kegg 0.436 NA no no no no up up P-hydroxyhippuric acid+urine Carbon metabolism 0.468421053 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Cardiac muscle contraction -0.710526316 0 0 urine_cometabolism kegg 0.436 NA no no no no no up P-hydroxyhippuric acid+urine CDCA+stool 0 0 0.630546956 urine_cometabolism stool_bileacids 0.436 0.663 no no no no no no P-hydroxyhippuric acid+urine Central carbon metabolism in cancer 0 0 -0.552307692 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Chemical carcinogenesis - receptor activation -0.554385965 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Chemokine signaling pathway 0 0 0.443076923 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Circadian entrainment -0.494736842 0 0.605384615 urine_cometabolism kegg 0.436 NA no no no no up up P-hydroxyhippuric acid+urine Clostridium 0.591290657 0 0 urine_cometabolism Genus 0.436 0.925 no no no no no no P-hydroxyhippuric acid+urine Cocaine addiction 0 0 0.428461538 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Collinsella 0 0 0.531100412 urine_cometabolism Genus 0.436 0.128 no no no no no no P-hydroxyhippuric acid+urine Cortisol synthesis and secretion 0 0 0.480769231 urine_cometabolism kegg 0.436 NA no no no no no up P-hydroxyhippuric acid+urine Cytokine-cytokine receptor interaction 0 0 0.42 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine d18:0-16:0-SM+blood 0 0 0.507792208 urine_cometabolism serum_phospholipids 0.436 0.202 no no no no no no P-hydroxyhippuric acid+urine d18:1-16:0-SM+blood 0 0 0.519480519 urine_cometabolism serum_phospholipids 0.436 0.14 no no no no no no P-hydroxyhippuric acid+urine d18:1-16:1-SM+blood 0 0 0.6 urine_cometabolism serum_phospholipids 0.436 0.2 no no no no no no P-hydroxyhippuric acid+urine d18:1-22:1-SM+blood 0 0 0.535064935 urine_cometabolism serum_phospholipids 0.436 0.222 no no no no no no P-hydroxyhippuric acid+urine Diabetic cardiomyopathy -0.677192982 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Dilated cardiomyopathy 0 0 0.491538462 urine_cometabolism kegg 0.436 NA no no no no up up P-hydroxyhippuric acid+urine Dopaminergic synapse -0.533333333 0 0 urine_cometabolism kegg 0.436 NA no no no no up no P-hydroxyhippuric acid+urine Endocrine and other factor-regulated calcium reabsorption 0 0.496491228 0.558461538 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine EPA+blood 0 0 -0.566233766 urine_cometabolism serum_ARA 0.436 0.212 no no no no no no P-hydroxyhippuric acid+urine Ethanolamine+blood 0 0 -0.554545455 urine_cometabolism serum_aminoacids 0.436 0.122 no no no up no no P-hydroxyhippuric acid+urine Gap junction 0 0 0.65 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Gastric acid secretion 0 0 0.435384615 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine GDCA+stool 0 0 0.627715924 urine_cometabolism stool_bileacids 0.436 0.656 no no no no no no P-hydroxyhippuric acid+urine Glucagon signaling pathway 0 0.475438596 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Glutathione metabolism 0 0 0.580769231 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine "Glycine, serine and threonine metabolism" 0 0 0.42 urine_cometabolism kegg 0.436 NA no no no no up no P-hydroxyhippuric acid+urine HCA+blood 0 0 0.566682089 urine_cometabolism serum_bileacids 0.436 0.544 no no no no no no P-hydroxyhippuric acid+urine HDCA+stool 0 0 -0.682146543 urine_cometabolism stool_bileacids 0.436 0.176 no no no no no no P-hydroxyhippuric acid+urine HIF-1 signaling pathway 0 0 -0.459230769 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Hippuric acid+urine 0 0 -0.537777778 urine_cometabolism urine_cometabolism 0.436 0.361 no no no no no no P-hydroxyhippuric acid+urine Homovanillic acid+urine 0.485714286 0 0 urine_cometabolism urine_cometabolism 0.436 0.45 no no no no no no P-hydroxyhippuric acid+urine Huntington disease -0.633333333 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Hypertrophic cardiomyopathy 0 0 0.414615385 urine_cometabolism kegg 0.436 NA no no no no up up P-hydroxyhippuric acid+urine Hypotaurine+blood -0.531862745 0 0 urine_cometabolism serum_aminoacids 0.436 0.933 no no no no no no P-hydroxyhippuric acid+urine Insulin secretion 0 0.473684211 0.434615385 yes urine_cometabolism kegg 0.436 NA no no no no up up P-hydroxyhippuric acid+urine iso-LCA+stool 0 0 -0.481940144 urine_cometabolism stool_bileacids 0.436 0.72 no no no no no no P-hydroxyhippuric acid+urine Kynurenic acid+urine 0 0 -0.417435897 urine_cometabolism urine_cometabolism 0.436 0.296 no no no no no no P-hydroxyhippuric acid+urine L-Homocystine+blood -0.654411765 0 0 urine_cometabolism serum_aminoacids 0.436 0.197 no no no no no no P-hydroxyhippuric acid+urine L-Lysine+blood 0 0 -0.496103896 yes urine_cometabolism serum_aminoacids 0.436 0.0107 no no no no up no P-hydroxyhippuric acid+urine L-Methionine+blood -0.536764706 0 -0.548051948 urine_cometabolism serum_aminoacids 0.436 0.626 no no no no no no P-hydroxyhippuric acid+urine L-Ornithine+blood -0.514705882 0 0 urine_cometabolism serum_aminoacids 0.436 0.175 no no no no no no P-hydroxyhippuric acid+urine L-Phenylalanine+blood 0 0 -0.468831169 yes urine_cometabolism serum_aminoacids 0.436 0.0103 no no no up up no P-hydroxyhippuric acid+urine LCA+blood -0.621070094 0 0 urine_cometabolism serum_bileacids 0.436 0.884 no no no no no no P-hydroxyhippuric acid+urine Leishmaniasis 0.50877193 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Long-term depression -0.50877193 0 0.601538462 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine MAPK signaling pathway 0 0 -0.534615385 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Melanogenesis 0 0.521052632 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine MicroRNAs in cancer 0 0 -0.436923077 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Mitophagy - animal -0.457894737 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Morphine addiction 0 0 0.506923077 urine_cometabolism kegg 0.436 NA no no no no up up P-hydroxyhippuric acid+urine mTOR signaling pathway 0 0 -0.482307692 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine n3+blood 0 0 -0.707792208 urine_cometabolism serum_fattyacid 0.436 0.806 no no no no no no P-hydroxyhippuric acid+urine n6/n3+blood 0 0 0.450649351 urine_cometabolism serum_fattyacid 0.436 0.226 no no no no no no P-hydroxyhippuric acid+urine Non-alcoholic fatty liver disease -0.654385965 0 0.416153846 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine nutriCA+blood 0 0 0.524662617 urine_cometabolism serum_bileacids 0.436 0.726 no no no no no no P-hydroxyhippuric acid+urine Oscillospira -0.460150376 0 0 LPS-producing urine_cometabolism Genus 0.436 0.62 no no no no no no P-hydroxyhippuric acid+urine Oxidative phosphorylation -0.677192982 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Pancreatic secretion -0.547368421 0 0.571538462 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine "Parathyroid hormone synthesis, secretion and action" -0.663157895 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Parkinson disease -0.661403509 0.501754386 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Pathways of neurodegeneration - multiple diseases -0.668421053 0.519298246 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0 -0.580769231 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Peroxisome 0.550877193 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Phenylacetic acid+stool -0.582417582 0 0 urine_cometabolism stool_cometabolism 0.436 0.785 no no no no no no P-hydroxyhippuric acid+urine PI3K-Akt signaling pathway 0 0 -0.423846154 yes urine_cometabolism kegg 0.436 NA no no no no up up P-hydroxyhippuric acid+urine Platelet activation 0 0 0.481538462 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Prion disease -0.692982456 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Progesterone-mediated oocyte maturation 0 0 -0.524615385 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Propionic acid+stool 0 0.7 0 yes urine_cometabolism stool_scfa 0.436 0.0436 no no no dn no up P-hydroxyhippuric acid+urine Proteasome 0 0 -0.420769231 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Regulation of lipolysis in adipocytes 0 0 0.493846154 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Renin secretion 0 0 0.526153846 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Retrograde endocannabinoid signaling -0.503508772 0 0 urine_cometabolism kegg 0.436 NA no no no no no up P-hydroxyhippuric acid+urine Ruminococcus -0.454135338 0 0 acetate-producing urine_cometabolism Genus 0.436 0.335 no no no no no no P-hydroxyhippuric acid+urine Serotonergic synapse -0.501754386 0 0.536923077 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine SFA+blood 0 -0.697802198 0 urine_cometabolism serum_fattyacid 0.436 0.0386 no no no up no no P-hydroxyhippuric acid+urine Shigellosis -0.543859649 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Spinocerebellar ataxia 0 0 -0.533846154 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine T cell receptor signaling pathway 0 0 -0.455384615 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Taurine+blood 0 0 -0.48961039 urine_cometabolism serum_aminoacids 0.436 0.857 no no no no no no P-hydroxyhippuric acid+urine TCA+blood 0.589160024 0 0 urine_cometabolism serum_bileacids 0.436 0.339 no no no no no no P-hydroxyhippuric acid+urine TCA+stool 0 0 0.595459236 urine_cometabolism stool_bileacids 0.436 0.458 no no no no no no P-hydroxyhippuric acid+urine Th1 and Th2 cell differentiation 0 -0.464912281 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Thermogenesis -0.694736842 0 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Thyroid hormone synthesis 0 0 0.693846154 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine total_stool_scfa+stool 0 0.933333333 0 urine_cometabolism stool_scfa 0.436 0.0534 no no no dn no up P-hydroxyhippuric acid+urine TUDCA+blood 0.560112034 0 0 yes urine_cometabolism serum_bileacids 0.436 0.0282 no no no no no dn P-hydroxyhippuric acid+urine Ubiquitin mediated proteolysis 0 0.498245614 0 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Vascular smooth muscle contraction -0.484210526 0.498245614 0.456153846 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Vasopressin-regulated water reabsorption 0 0 0.558461538 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Vibrio cholerae infection 0 0 0.419230769 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Viral myocarditis 0 0 0.433846154 urine_cometabolism kegg 0.436 NA no no no no no no P-hydroxyhippuric acid+urine Viral protein interaction with cytokine and cytokine receptor 0 0 0.652307692 urine_cometabolism kegg 0.436 NA no no no no no no p53 signaling pathway ABC transporters 0 0.829051383 0.446846847 kegg kegg NA NA no no no no up up p53 signaling pathway Amino sugar and nucleotide sugar metabolism 0 0.526679842 0 kegg kegg NA NA no no no no no no p53 signaling pathway Aminoacyl-tRNA biosynthesis 0 0 0.480823681 kegg kegg NA NA no no no no no no p53 signaling pathway Antifolate resistance 0 0 0.405405405 kegg kegg NA NA no no no no no no p53 signaling pathway Basal transcription factors 0.675652174 0.490118577 0.651480051 kegg kegg NA NA no no no no no no p53 signaling pathway Base excision repair 0.717391304 0.575098814 0.555984556 kegg kegg NA NA no no no no no no p53 signaling pathway Biosynthesis of amino acids -0.489565217 0 -0.544658945 kegg kegg NA NA no no no no no no p53 signaling pathway Carbon metabolism -0.492173913 -0.77173913 -0.529472329 kegg kegg NA NA no no no no no no p53 signaling pathway Cell cycle 0.56173913 0 0.598455598 kegg kegg NA NA no no no no no no p53 signaling pathway cGMP-PKG signaling pathway 0 0 -0.41029601 kegg kegg NA NA no no no no no no p53 signaling pathway Chemokine signaling pathway 0 0 -0.647361647 kegg kegg NA NA no no no no no no p53 signaling pathway Clostridium 0 -0.611283284 0 kegg Genus NA 0.925 no no no no no no p53 signaling pathway DNA replication 0 0 0.493693694 kegg kegg NA NA no no no no no no p53 signaling pathway EGFR tyrosine kinase inhibitor resistance 0.435652174 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Endocrine resistance 0 0.43972332 0 kegg kegg NA NA no no no no no no p53 signaling pathway ErbB signaling pathway 0.520869565 0.433794466 0 kegg kegg NA NA no no no no no no p53 signaling pathway Ether lipid metabolism 0 0 0.570913771 kegg kegg NA NA no no no no no no p53 signaling pathway Eubacterium 0 0 0.403984941 kegg Genus NA 0.0692 no no no no no no p53 signaling pathway Fanconi anemia pathway 0.52173913 0.605731225 0.65045045 kegg kegg NA NA no no no no no no p53 signaling pathway Fatty acid elongation 0 -0.441699605 0 kegg kegg NA NA no no no no no no p53 signaling pathway FoxO signaling pathway 0.466956522 0.623517787 0.567824968 kegg kegg NA NA no no no no no no p53 signaling pathway Glycerolipid metabolism 0 0.725296443 0 kegg kegg NA NA no no no no no up p53 signaling pathway Glycerophospholipid metabolism 0.724347826 0.841897233 0.581981982 kegg kegg NA NA no no no no no up p53 signaling pathway Glycolysis / Gluconeogenesis 0 -0.597826087 0 kegg kegg NA NA no no no no no no p53 signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.51826087 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Glycosaminoglycan degradation -0.543478261 0 0 kegg kegg NA NA no no no no no up p53 signaling pathway Glycosphingolipid biosynthesis - globo and isoglobo series -0.586086957 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.575652174 0.705533597 0.45997426 kegg kegg NA NA no no no no no no p53 signaling pathway Homologous recombination 0.505217391 0.752964427 0.747232947 kegg kegg NA NA no no no no no no p53 signaling pathway Inositol phosphate metabolism 0 0.761857708 0.544144144 kegg kegg NA NA no no no no no no p53 signaling pathway Lachnospira 0 -0.451692626 0 butyrate-producing kegg Genus NA 0.279 no no no no no no p53 signaling pathway Linoleic acid metabolism -0.462608696 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Lysine degradation 0.572173913 0.672924901 0.527413127 kegg kegg NA NA no no no no no no p53 signaling pathway Mannose type O-glycan biosynthesis 0 0.539525692 0.518661519 kegg kegg NA NA no no no no no no p53 signaling pathway MAPK signaling pathway 0.435652174 0.52173913 0 kegg kegg NA NA no no no no no no p53 signaling pathway mRNA surveillance pathway 0.586956522 0 0.536936937 kegg kegg NA NA no no no no no no p53 signaling pathway Mucin type O-glycan biosynthesis 0 0.448616601 0.451994852 kegg kegg NA NA no no no no no no p53 signaling pathway N-Glycan biosynthesis 0.571304348 0 0.454311454 kegg kegg NA NA no no no no no no p53 signaling pathway Neuroactive ligand-receptor interaction -0.466086957 -0.429841897 -0.505276705 kegg kegg NA NA no no no up up up p53 signaling pathway NF-kappa B signaling pathway 0.426086957 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Nucleotide excision repair 0 0 0.571428571 kegg kegg NA NA no no no no no no p53 signaling pathway One carbon pool by folate 0 0 0.481338481 kegg kegg NA NA no no no no no no p53 signaling pathway Other glycan degradation 0 0.54743083 0 kegg kegg NA NA no no no no no no p53 signaling pathway Other types of O-glycan biosynthesis 0.73826087 0.816205534 0.706563707 kegg kegg NA NA no no no no no no p53 signaling pathway Paraprevotella -0.552433694 0 0 kegg Genus NA 0.118 no no no no no no p53 signaling pathway Pentose phosphate pathway -0.528695652 -0.451581028 0 kegg kegg NA NA no no no no no no p53 signaling pathway Phenylalanine metabolism -0.549565217 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Phosphatidylinositol signaling system 0.585217391 0.507905138 0.621364221 kegg kegg NA NA no no no no no no p53 signaling pathway Platinum drug resistance 0.856521739 0.821146245 0.775289575 kegg kegg NA NA no no no no no no p53 signaling pathway PPAR signaling pathway 0 0 -0.58018018 kegg kegg NA NA no no no no no no p53 signaling pathway Protein export 0.532173913 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Pyrimidine metabolism 0 0 0.505791506 kegg kegg NA NA no no no no no no p53 signaling pathway Rap1 signaling pathway -0.800869565 -0.691699605 -0.654311454 kegg kegg NA NA no no no no no no p53 signaling pathway Ras signaling pathway 0 0 0.464864865 yes kegg kegg NA NA no no no no up up p53 signaling pathway Ribosome biogenesis in eukaryotes 0.70173913 0.427865613 0.581981982 kegg kegg NA NA no no no no no no p53 signaling pathway RNA degradation 0.51826087 0 0.46048906 kegg kegg NA NA no no no no no no p53 signaling pathway RNA polymerase 0.692173913 0 0.540797941 kegg kegg NA NA no no no no no no p53 signaling pathway Selenocompound metabolism 0.842608696 0.684782609 0.712741313 kegg kegg NA NA no no no no no no p53 signaling pathway Sphingolipid metabolism -0.445217391 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Spliceosome 0.717391304 0.807312253 0.576833977 kegg kegg NA NA no no no no no no p53 signaling pathway Steroid biosynthesis 0 0 0.403346203 kegg kegg NA NA no no no no no no p53 signaling pathway Taurine and hypotaurine metabolism 0.733043478 0.698616601 0.433462033 kegg kegg NA NA no no no no no no p53 signaling pathway Terpenoid backbone biosynthesis 0.445217391 0 0.503732304 kegg kegg NA NA no no no no no no p53 signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 0 0.455855856 kegg kegg NA NA no no no no no no p53 signaling pathway Various types of N-glycan biosynthesis 0.559130435 0 0 kegg kegg NA NA no no no no no no p53 signaling pathway Viral protein interaction with cytokine and cytokine receptor 0 0 -0.487773488 kegg kegg NA NA no no no no no no PAI-1 16:1/16:1-PC+blood 0 -0.666666667 -0.466956522 yes DM-assocaited hormones serum_phospholipids 5.10E-05 0.0177 up up up no no up PAI-1 18:0-LPC+blood 0 0 0.476521739 yes DM-assocaited hormones serum_phospholipids 5.10E-05 0.554 up up up no no no PAI-1 18:0/22:6-PA+blood 0 -0.541666667 0 yes DM-assocaited hormones serum_phospholipids 5.10E-05 0.22 up up up no no no PAI-1 18:1/18:1-PC+blood 0.558307534 0 0 yes DM-assocaited hormones serum_phospholipids 5.10E-05 1.34E-05 up up up no up up PAI-1 18:2-LPC+blood 0.496388029 0.551470588 0 yes DM-assocaited hormones serum_phospholipids 5.10E-05 0.00743 up up up dn no up PAI-1 18:2/18:2-PC+blood 0.531475748 0 0 yes DM-assocaited hormones serum_phospholipids 5.10E-05 1.98E-05 up up up dn up up PAI-1 20:0/20:5-PC+blood 0 -0.610294118 0 yes DM-assocaited hormones serum_phospholipids 5.10E-05 0.882 up up up no no no PAI-1 20:0+blood 0.673890609 0 0 yes yes DM-assocaited hormones serum_fattyacid 5.10E-05 0.000278 up up up dn no up PAI-1 20:3/18:0-PC+blood 0 -0.595588235 0 yes DM-assocaited hormones serum_phospholipids 5.10E-05 0.296 up up up no no no PAI-1 20:4-LPC+blood 0 0 0.433913043 yes DM-assocaited hormones serum_phospholipids 5.10E-05 0.949 up up up no no no PAI-1 22:6n3+blood -0.51496388 0 0 yes DM-assocaited hormones serum_fattyacid 5.10E-05 0.792 up up up no no no PAI-1 AA+blood 0 0 0.557391304 yes DM-assocaited hormones serum_ARA 5.10E-05 0.212 up up up no no no PAI-1 Alistipes 0.520556326 0 0 yes DM-assocaited hormones Genus 5.10E-05 0.0114 up up up no up no PAI-1 Amyotrophic lateral sclerosis 0.452286844 0 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 Anaerostipes 0 0 -0.479700042 yes butyrate-producing DM-assocaited hormones Genus 5.10E-05 0.568 up up up no no no PAI-1 Butyric acid+stool 0 0 0.450649351 yes yes DM-assocaited hormones stool_scfa 5.10E-05 0.102 up up up dn no no PAI-1 C-peptide 0.475296443 0 0 yes DM-assocaited hormones DM-assocaited hormones 5.10E-05 0.228 up up up no no no PAI-1 cGMP-PKG signaling pathway -0.425183512 0 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 Chronic myeloid leukemia 0 0 0.410093583 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 Cytosolic DNA-sensing pathway 0.436476567 0 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 DL-methionine sulfoxide+blood -0.5500516 0 0 yes DM-assocaited hormones serum_aminoacids 5.10E-05 0.302 up up up no no no PAI-1 Ethanolamine+blood 0 0 0.527826087 yes DM-assocaited hormones serum_aminoacids 5.10E-05 0.122 up up up up no no PAI-1 Faecalibacterium 0 0.420869565 0 yes butyrate-producing DM-assocaited hormones Genus 5.10E-05 0.0039 up up up no dn dn PAI-1 Fc gamma R-mediated phagocytosis -0.463579898 0 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 FGF basic 0.681318681 0 0 yes DM-assocaited hormones serum_cytokines 5.10E-05 0.65 up up up no no no PAI-1 GABAergic synapse -0.604743083 0 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no up up PAI-1 HDCA+stool 0.541176471 0 0 yes DM-assocaited hormones stool_bileacids 5.10E-05 0.176 up up up no no no PAI-1 Hematopoietic cell lineage 0 0 -0.44618984 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 Homovanillic acid+urine -0.69246646 0 -0.506916996 yes DM-assocaited hormones urine_cometabolism 5.10E-05 0.45 up up up no no no PAI-1 Hypotaurine+blood 0 0 0.5 yes DM-assocaited hormones serum_aminoacids 5.10E-05 0.933 up up up no no no PAI-1 Kaposi sarcoma-associated herpesvirus infection 0 0.41798419 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no dn PAI-1 L-Alanine+blood 0 0 0.406956522 yes yes DM-assocaited hormones serum_aminoacids 5.10E-05 0.00138 up up up up up no PAI-1 L-Citrulline+blood 0 0 0.610434783 yes DM-assocaited hormones serum_aminoacids 5.10E-05 0.534 up up up no no no PAI-1 L-Isoleucine+blood 0 0 0.42 yes yes DM-assocaited hormones serum_aminoacids 5.10E-05 5.47E-06 up up up up up no PAI-1 L-Methionine+blood 0 0 0.543478261 yes DM-assocaited hormones serum_aminoacids 5.10E-05 0.626 up up up no no no PAI-1 L-Proline+blood 0 0 0.405217391 yes yes DM-assocaited hormones serum_aminoacids 5.10E-05 0.00265 up up up up up no PAI-1 L-Tryptophan+blood 0 0 0.434782609 yes DM-assocaited hormones serum_aminoacids 5.10E-05 0.164 up up up no no no PAI-1 L-Tryptophan+urine 0.671826625 0 0.566205534 yes DM-assocaited hormones urine_cometabolism 5.10E-05 0.226 up up up no no no PAI-1 L-Tyrosine+blood 0 0 0.431304348 yes yes DM-assocaited hormones serum_aminoacids 5.10E-05 0.00913 up up up up up no PAI-1 L-Tyrosine+urine 0 0 0.522727273 yes DM-assocaited hormones urine_cometabolism 5.10E-05 0.45 up up up no no no PAI-1 Lachnospira -0.470355731 0 0 yes butyrate-producing DM-assocaited hormones Genus 5.10E-05 0.279 up up up no no no PAI-1 Leptin -0.41798419 -0.451304348 0 yes DM-assocaited hormones DM-assocaited hormones 5.10E-05 0.706 up up up no no no PAI-1 Longevity regulating pathway - multiple species 0 -0.5 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 Mineral absorption 0 0.46541502 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 Mitophagy - animal 0 0.479249012 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 Necroptosis 0 0.470355731 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 Neutrophil extracellular trap formation -0.429700734 0 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 Olfactory transduction -0.476002259 0 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 Oscillospira 0 -0.425217391 0 yes LPS-producing DM-assocaited hormones Genus 5.10E-05 0.62 up up up no no no PAI-1 "Parathyroid hormone synthesis, secretion and action" 0 0.477272727 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 PDGF-bb 0 0.777922078 0.492063492 yes yes DM-assocaited hormones serum_cytokines 5.10E-05 0.111 up up up no no no PAI-1 Peroxisome -0.649915302 0 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 Phenylacetyl L-GlutaMine+urine 0.473684211 0 0 yes DM-assocaited hormones urine_cometabolism 5.10E-05 0.0909 up up up up no no PAI-1 Prevotella 0 0 0.426570367 yes acetate-producing DM-assocaited hormones Genus 5.10E-05 0.287 up up up no no no PAI-1 Primary immunodeficiency 0 -0.4743083 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 Prostate cancer 0 0 0.423128342 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 Rothia 0 0 -0.411133216 yes DM-assocaited hormones Genus 5.10E-05 0.313 up up up no no no PAI-1 Ruminococcus 0.554347826 0 0 yes acetate-producing DM-assocaited hormones Genus 5.10E-05 0.335 up up up no no no PAI-1 SFA%+blood 0.475748194 0 0 yes DM-assocaited hormones serum_fattyacid 5.10E-05 0.0236 up up up no up no PAI-1 Shigellosis 0 0.449604743 0 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no PAI-1 TCA+stool -0.551624819 0 -0.463636364 yes DM-assocaited hormones stool_bileacids 5.10E-05 0.458 up up up no no no PAI-1 Toxoplasmosis 0 0 -0.407085561 yes DM-assocaited hormones kegg 5.10E-05 NA up up up no no no Pancreatic cancer 2-Oxocarboxylic acid metabolism -0.492173913 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Adrenergic signaling in cardiomyocytes 0.410434783 0 0 kegg kegg NA NA no no no no no up Pancreatic cancer African trypanosomiasis 0.484347826 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer AGE-RAGE signaling pathway in diabetic complications 0.44 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Aldosterone-regulated sodium reabsorption 0.763478261 0.431818182 0 kegg kegg NA NA no no no no no no Pancreatic cancer Amino sugar and nucleotide sugar metabolism -0.568695652 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Apoptosis - multiple species 0 0.424901186 0.653539254 kegg kegg NA NA no no no no no no Pancreatic cancer Arachidonic acid metabolism -0.64 -0.59486166 0 kegg kegg NA NA no no no no no no Pancreatic cancer Autophagy - animal 0 0 0.413899614 kegg kegg NA NA no no no no no no Pancreatic cancer Autophagy - other 0 0.480237154 0.408494208 kegg kegg NA NA no no no no no no Pancreatic cancer Axon guidance 0.700869565 0 0 kegg kegg NA NA no no no no up up Pancreatic cancer beta-Alanine metabolism -0.482608696 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Biosynthesis of amino acids 0 0 -0.405405405 kegg kegg NA NA no no no no no no Pancreatic cancer Biosynthesis of cofactors -0.579130435 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Butanoate metabolism -0.482608696 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer C-type lectin receptor signaling pathway 0.453043478 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Calcium signaling pathway 0.524347826 0 0 kegg kegg NA NA no no no no up up Pancreatic cancer cAMP signaling pathway 0.487826087 0 0 yes kegg kegg NA NA no no no no up up Pancreatic cancer Carbohydrate digestion and absorption 0.433043478 0.553359684 0 kegg kegg NA NA no no no no no no Pancreatic cancer Carbon metabolism -0.408695652 0 -0.416216216 kegg kegg NA NA no no no no no no Pancreatic cancer Cell cycle 0 0 0.508108108 kegg kegg NA NA no no no no no no Pancreatic cancer cGMP-PKG signaling pathway 0.548695652 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Chemical carcinogenesis - DNA adducts -0.406956522 -0.472332016 -0.510939511 kegg kegg NA NA no no no no no no Pancreatic cancer Chemokine signaling pathway 0.430434783 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Cholinergic synapse 0.430434783 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Circadian rhythm 0.504347826 0.435770751 0.428314028 kegg kegg NA NA no no no no no no Pancreatic cancer Collecting duct acid secretion 0 -0.427865613 0 kegg kegg NA NA no no no no no no Pancreatic cancer Colorectal cancer 0.6 0.679841897 0.504247104 kegg kegg NA NA no no no no no no Pancreatic cancer Cytokine-cytokine receptor interaction 0.453043478 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Drug metabolism - cytochrome P450 0 0 -0.424710425 kegg kegg NA NA no no no no no no Pancreatic cancer Drug metabolism - other enzymes -0.406956522 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Epithelial cell signaling in Helicobacter pylori infection 0 0 -0.441184041 kegg kegg NA NA no no no no no no Pancreatic cancer ErbB signaling pathway 0.613913043 0.606719368 0.47953668 kegg kegg NA NA no no no no no no Pancreatic cancer Fanconi anemia pathway 0 0 0.447619048 kegg kegg NA NA no no no no no no Pancreatic cancer Fat digestion and absorption 0 0 -0.457400257 yes kegg kegg NA NA no no no no up up Pancreatic cancer Fc epsilon RI signaling pathway 0.584347826 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer FoxO signaling pathway 0.444347826 0 0.614671815 kegg kegg NA NA no no no no no no Pancreatic cancer Fructose and mannose metabolism -0.611304348 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Galactose metabolism -0.469565217 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Glutathione metabolism -0.48173913 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Glycerophospholipid metabolism 0 0 0.432689833 kegg kegg NA NA no no no no no up Pancreatic cancer "Glycine, serine and threonine metabolism" -0.433043478 0 0 kegg kegg NA NA no no no no up no Pancreatic cancer Glycolysis / Gluconeogenesis -0.488695652 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Glycosaminoglycan biosynthesis - keratan sulfate 0 0.5256917 0.507335907 kegg kegg NA NA no no no no no no Pancreatic cancer GnRH secretion 0.649565217 0.532608696 0.54980695 kegg kegg NA NA no no no no up up Pancreatic cancer Hedgehog signaling pathway 0.53826087 0 0.446332046 kegg kegg NA NA no no no no no no Pancreatic cancer Hepatitis B 0.455652174 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Hepatitis C 0.522608696 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Histidine metabolism -0.466086957 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Homologous recombination 0 0 0.525868726 kegg kegg NA NA no no no no no no Pancreatic cancer Inositol phosphate metabolism 0 0 0.50990991 kegg kegg NA NA no no no no no no Pancreatic cancer JAK-STAT signaling pathway 0 0 0.546460746 kegg kegg NA NA no no no no no no Pancreatic cancer Long-term potentiation 0.547826087 0 0 kegg kegg NA NA no no no no no up Pancreatic cancer Mannose type O-glycan biosynthesis 0 0.48715415 0 kegg kegg NA NA no no no no no no Pancreatic cancer MAPK signaling pathway 0 0 0.454311454 kegg kegg NA NA no no no no no no Pancreatic cancer Metabolism of xenobiotics by cytochrome P450 0 0 -0.46048906 kegg kegg NA NA no no no no no no Pancreatic cancer MicroRNAs in cancer 0 0 0.525868726 kegg kegg NA NA no no no no no no Pancreatic cancer Mucin type O-glycan biosynthesis 0 0 0.492406692 kegg kegg NA NA no no no no no no Pancreatic cancer N-Glycan biosynthesis 0 0 0.471557272 kegg kegg NA NA no no no no no no Pancreatic cancer Neurotrophin signaling pathway 0.593043478 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Neutrophil extracellular trap formation 0 0 -0.444787645 kegg kegg NA NA no no no no no no Pancreatic cancer Notch signaling pathway 0.442608696 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Other glycan degradation -0.440869565 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Other types of O-glycan biosynthesis 0 0 0.535649936 kegg kegg NA NA no no no no no no Pancreatic cancer p53 signaling pathway 0 0 0.680823681 kegg kegg NA NA no no no no no no Pancreatic cancer Pathogenic Escherichia coli infection 0 0 -0.51969112 kegg kegg NA NA no no no no no no Pancreatic cancer Pathways in cancer 0.556521739 0 0.516602317 kegg kegg NA NA no no no no no no Pancreatic cancer Phagosome 0 0 -0.441441441 kegg kegg NA NA no no no no no no Pancreatic cancer Phosphatidylinositol signaling system 0.580869565 0.606719368 0.597168597 kegg kegg NA NA no no no no no no Pancreatic cancer Platinum drug resistance 0 0.531620553 0.688803089 kegg kegg NA NA no no no no no no Pancreatic cancer Porphyrin and chlorophyll metabolism -0.465217391 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Progesterone-mediated oocyte maturation 0 0.462450593 0.413384813 kegg kegg NA NA no no no no no no Pancreatic cancer Prolactin signaling pathway 0.517391304 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Proximal tubule bicarbonate reclamation 0 0 0.400514801 kegg kegg NA NA no no no no no no Pancreatic cancer Pyrimidine metabolism -0.442608696 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Ras signaling pathway 0.776521739 0 0.475933076 yes kegg kegg NA NA no no no no up up Pancreatic cancer Renal cell carcinoma 0.707826087 0.447628458 0 kegg kegg NA NA no no no no no no Pancreatic cancer Ruminococcus 0 -0.42050649 0 kegg Genus NA 0.0679 no no no no no dn Pancreatic cancer Ruminococcus -0.415652174 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Pancreatic cancer Selenocompound metabolism 0 0 0.461776062 kegg kegg NA NA no no no no no no Pancreatic cancer Serotonergic synapse 0 -0.442687747 0 kegg kegg NA NA no no no no no no Pancreatic cancer Signaling pathways regulating pluripotency of stem cells 0.667826087 0.585968379 0.658944659 kegg kegg NA NA no no no no no no Pancreatic cancer Sphingolipid signaling pathway 0.81826087 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Spinocerebellar ataxia 0 0.567193676 0 kegg kegg NA NA no no no no no no Pancreatic cancer Spliceosome 0 0.493083004 0.403088803 kegg kegg NA NA no no no no no no Pancreatic cancer Steroid hormone biosynthesis -0.447826087 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Terpenoid backbone biosynthesis 0 0 0.453796654 kegg kegg NA NA no no no no no no Pancreatic cancer TGF-beta signaling pathway 0.465217391 0 0.442471042 kegg kegg NA NA no no no no no no Pancreatic cancer Tryptophan metabolism -0.453043478 0 0 kegg kegg NA NA no no no no up no Pancreatic cancer Type II diabetes mellitus 0.473043478 0.421936759 0 kegg kegg NA NA no no no no no no Pancreatic cancer Tyrosine metabolism -0.425217391 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Ubiquinone and other terpenoid-quinone biosynthesis -0.466086957 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer "Valine, leucine and isoleucine degradation" -0.448695652 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer VEGF signaling pathway 0.813043478 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Viral protein interaction with cytokine and cytokine receptor 0.470434783 0 0 kegg kegg NA NA no no no no no no Pancreatic cancer Wnt signaling pathway 0.5 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion 2-Oxocarboxylic acid metabolism -0.452173913 0 -0.472329472 kegg kegg NA NA no no no no no no Pancreatic secretion ABC transporters -0.730434783 0 0 kegg kegg NA NA no no no no up up Pancreatic secretion Adherens junction 0 0.616600791 0 kegg kegg NA NA no no no no no no Pancreatic secretion Adrenergic signaling in cardiomyocytes 0.848695652 0.792490119 0.738996139 kegg kegg NA NA no no no no no up Pancreatic secretion AGE-RAGE signaling pathway in diabetic complications 0 -0.608695652 0 kegg kegg NA NA no no no no no no Pancreatic secretion "Alanine, aspartate and glutamate metabolism" -0.543478261 -0.698616601 0 kegg kegg NA NA no no no no no no Pancreatic secretion Aldosterone synthesis and secretion 0.893043478 0.822134387 0.863577864 kegg kegg NA NA no no no no up up Pancreatic secretion alpha-Linolenic acid metabolism -0.71826087 -0.593873518 -0.594337194 kegg kegg NA NA no no no no no no Pancreatic secretion Amino sugar and nucleotide sugar metabolism -0.643478261 0 -0.483655084 kegg kegg NA NA no no no no no no Pancreatic secretion Aminoacyl-tRNA biosynthesis -0.644347826 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Apelin signaling pathway 0 0.51284585 0 kegg kegg NA NA no no no no no no Pancreatic secretion Apoptosis 0 -0.451581028 0 kegg kegg NA NA no no no no no no Pancreatic secretion Arginine and proline metabolism -0.570434783 -0.536561265 0 kegg kegg NA NA no no no no up no Pancreatic secretion Arginine biosynthesis -0.533913043 -0.653162055 0 kegg kegg NA NA no no no no no no Pancreatic secretion Ascorbate and aldarate metabolism 0 0 -0.575032175 kegg kegg NA NA no no no no no no Pancreatic secretion Autophagy - animal 0 -0.628458498 -0.412612613 kegg kegg NA NA no no no no no no Pancreatic secretion Autophagy - other 0 -0.427865613 0 kegg kegg NA NA no no no no no no Pancreatic secretion Axon guidance 0.443478261 0 0 kegg kegg NA NA no no no no up up Pancreatic secretion B cell receptor signaling pathway 0 -0.458498024 0 kegg kegg NA NA no no no no no no Pancreatic secretion Base excision repair -0.42173913 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion beta-Alanine metabolism -0.606956522 0 -0.448906049 kegg kegg NA NA no no no no no no Pancreatic secretion Biosynthesis of amino acids -0.547826087 -0.665019763 0 kegg kegg NA NA no no no no no no Pancreatic secretion Biosynthesis of unsaturated fatty acids -0.453043478 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Butanoate metabolism -0.540869565 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Butyricimonas 0.498345926 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Pancreatic secretion C-type lectin receptor signaling pathway 0 -0.574110672 0 kegg kegg NA NA no no no no no no Pancreatic secretion Calcium signaling pathway 0.812173913 0.830039526 0.698326898 kegg kegg NA NA no no no no up up Pancreatic secretion cAMP signaling pathway 0.66173913 0 0.589189189 yes kegg kegg NA NA no no no no up up Pancreatic secretion Carbon metabolism -0.522608696 0 -0.493436293 kegg kegg NA NA no no no no no no Pancreatic secretion Cardiac muscle contraction 0.686086957 0.725296443 0 kegg kegg NA NA no no no no no up Pancreatic secretion Cell adhesion molecules 0 -0.485177866 0 kegg kegg NA NA no no no no no no Pancreatic secretion cGMP-PKG signaling pathway 0 -0.526679842 0 kegg kegg NA NA no no no no no no Pancreatic secretion Circadian entrainment 0.659130435 0.735177866 0.846846847 kegg kegg NA NA no no no no up up Pancreatic secretion Citrate cycle (TCA cycle) -0.427826087 0 -0.495238095 kegg kegg NA NA no no no no no no Pancreatic secretion Complement and coagulation cascades 0 -0.499011858 0 kegg kegg NA NA no no no no no no Pancreatic secretion Cortisol synthesis and secretion 0.771304348 0.632411067 0.911196911 kegg kegg NA NA no no no no no up Pancreatic secretion Cushing syndrome 0.748695652 0.621541502 0.772200772 kegg kegg NA NA no no no no no up Pancreatic secretion DNA replication -0.405217391 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Dopaminergic synapse 0.760869565 0.833992095 0.789446589 kegg kegg NA NA no no no no up no Pancreatic secretion Drug metabolism - cytochrome P450 0 0.422924901 0 kegg kegg NA NA no no no no no no Pancreatic secretion Drug metabolism - other enzymes -0.546086957 0.454545455 -0.61981982 kegg kegg NA NA no no no no no no Pancreatic secretion EGFR tyrosine kinase inhibitor resistance 0 0.425889328 0 kegg kegg NA NA no no no no no no Pancreatic secretion Endocrine and other factor-regulated calcium reabsorption 0.924347826 0.914031621 0.931788932 kegg kegg NA NA no no no no no no Pancreatic secretion Endocrine resistance 0.693043478 0.491106719 0.79047619 kegg kegg NA NA no no no no no no Pancreatic secretion Endocytosis 0 -0.461462451 0 kegg kegg NA NA no no no no no no Pancreatic secretion Estrogen signaling pathway 0 0 0.478764479 kegg kegg NA NA no no no no no no Pancreatic secretion Ether lipid metabolism 0.451304348 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Fanconi anemia pathway -0.425217391 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Fatty acid biosynthesis -0.493043478 -0.693675889 0 kegg kegg NA NA no no no no no no Pancreatic secretion Fatty acid degradation -0.776521739 -0.796442688 -0.710939511 kegg kegg NA NA no no no no no no Pancreatic secretion Fatty acid elongation -0.41826087 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Fatty acid metabolism -0.769565217 -0.759881423 -0.575289575 kegg kegg NA NA no no no no no no Pancreatic secretion Fc epsilon RI signaling pathway 0 -0.546442688 0 kegg kegg NA NA no no no no no no Pancreatic secretion Fc gamma R-mediated phagocytosis -0.505217391 -0.649209486 0 kegg kegg NA NA no no no no no no Pancreatic secretion Ferroptosis 0.486956522 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Focal adhesion 0 0.483201581 0 kegg kegg NA NA no no no no up up Pancreatic secretion FoxO signaling pathway 0 -0.609683794 0 kegg kegg NA NA no no no no no no Pancreatic secretion Fructose and mannose metabolism -0.65826087 0 -0.623938224 kegg kegg NA NA no no no no no no Pancreatic secretion Galactose metabolism -0.684347826 -0.616600791 -0.669240669 kegg kegg NA NA no no no no no no Pancreatic secretion Gap junction 0.697391304 0.526679842 0.748519949 kegg kegg NA NA no no no no no no Pancreatic secretion Gastric acid secretion 0.476521739 0.763833992 0 kegg kegg NA NA no no no no no no Pancreatic secretion Glucagon signaling pathway 0.61826087 0.72826087 0.604633205 kegg kegg NA NA no no no no no no Pancreatic secretion Glutamatergic synapse 0.635652174 0 0.643758044 kegg kegg NA NA no no no no up up Pancreatic secretion Glutathione metabolism 0 0.616600791 0 kegg kegg NA NA no no no no no no Pancreatic secretion Glycerolipid metabolism -0.536521739 0 0 kegg kegg NA NA no no no no no up Pancreatic secretion Glycolysis / Gluconeogenesis -0.503478261 0 -0.413384813 kegg kegg NA NA no no no no no no Pancreatic secretion Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.455533597 0 kegg kegg NA NA no no no no no no Pancreatic secretion Glycosaminoglycan biosynthesis - keratan sulfate 0.623478261 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Glycosaminoglycan degradation 0 0 -0.58996139 kegg kegg NA NA no no no no no up Pancreatic secretion Glyoxylate and dicarboxylate metabolism -0.687826087 -0.674901186 0 kegg kegg NA NA no no no no no no Pancreatic secretion GnRH signaling pathway 0.811304348 0.652173913 0.863320463 kegg kegg NA NA no no no no no no Pancreatic secretion "Growth hormone synthesis, secretion and action" 0.425217391 0 0.588159588 kegg kegg NA NA no no no no no no Pancreatic secretion Hippo signaling pathway 0 0.583003953 0 kegg kegg NA NA no no no no no no Pancreatic secretion Hippo signaling pathway - multiple species 0 -0.448616601 -0.421621622 kegg kegg NA NA no no no no no no Pancreatic secretion Histidine metabolism -0.615652174 0 -0.599485199 kegg kegg NA NA no no no no no no Pancreatic secretion Homologous recombination -0.476521739 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion IL-17 signaling pathway 0 -0.507905138 0 kegg kegg NA NA no no no no no no Pancreatic secretion Inflammatory mediator regulation of TRP channels 0.813043478 0.786561265 0.836550837 kegg kegg NA NA no no no no no no Pancreatic secretion Inositol phosphate metabolism -0.494782609 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Insulin secretion 0.747826087 0.721343874 0.887258687 yes kegg kegg NA NA no no no no up up Pancreatic secretion Insulin signaling pathway 0 0.433794466 0 kegg kegg NA NA no no no no no no Pancreatic secretion JAK-STAT signaling pathway -0.410434783 -0.586956522 0 kegg kegg NA NA no no no no no no Pancreatic secretion Linoleic acid metabolism 0 0.458498024 0 kegg kegg NA NA no no no no no no Pancreatic secretion Long-term depression 0.948695652 0.574110672 0.876190476 kegg kegg NA NA no no no no no no Pancreatic secretion Longevity regulating pathway - multiple species 0 -0.528656126 0 kegg kegg NA NA no no no no no no Pancreatic secretion Lysosome 0 0 -0.45045045 kegg kegg NA NA no no no no no no Pancreatic secretion MAPK signaling pathway 0 -0.624505929 -0.40952381 kegg kegg NA NA no no no no no no Pancreatic secretion Melanogenesis 0.822608696 0.864624506 0.890604891 kegg kegg NA NA no no no no no no Pancreatic secretion Mismatch repair -0.473913043 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Mitophagy - animal 0.64173913 0.576086957 0 kegg kegg NA NA no no no no no no Pancreatic secretion mRNA surveillance pathway 0.430434783 0.565217391 0 kegg kegg NA NA no no no no no no Pancreatic secretion Mucin type O-glycan biosynthesis 0 -0.541501976 0 kegg kegg NA NA no no no no no no Pancreatic secretion N-Glycan biosynthesis 0 0.488142292 0 kegg kegg NA NA no no no no no no Pancreatic secretion Natural killer cell mediated cytotoxicity 0 -0.42687747 0 kegg kegg NA NA no no no no no no Pancreatic secretion Necroptosis 0.554782609 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Neuroactive ligand-receptor interaction 0 -0.54743083 0 kegg kegg NA NA no no no up up up Pancreatic secretion Neutrophil extracellular trap formation 0 -0.461462451 0 kegg kegg NA NA no no no no no no Pancreatic secretion NF-kappa B signaling pathway -0.553913043 -0.543478261 0 kegg kegg NA NA no no no no no no Pancreatic secretion Nicotinate and nicotinamide metabolism -0.564347826 -0.576086957 0 kegg kegg NA NA no no no no no no Pancreatic secretion Nitrogen metabolism 0 -0.492094862 0 kegg kegg NA NA no no no no no no Pancreatic secretion NOD-like receptor signaling pathway -0.606086957 -0.741106719 0 kegg kegg NA NA no no no no no no Pancreatic secretion Non-alcoholic fatty liver disease 0.679130435 0.693675889 0.507850708 kegg kegg NA NA no no no no no no Pancreatic secretion Non-homologous end-joining -0.523478261 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Nucleotide excision repair -0.417391304 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Odoribacter -0.479268035 0 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Pancreatic secretion Olfactory transduction 0 -0.498023715 -0.469240669 kegg kegg NA NA no no no no no no Pancreatic secretion Oscillospira 0 -0.516798419 0 LPS-producing kegg Genus NA 0.62 no no no no no no Pancreatic secretion Osteoclast differentiation -0.500869565 -0.716403162 0 kegg kegg NA NA no no no no no no Pancreatic secretion Other glycan degradation -0.635652174 0 -0.414671815 kegg kegg NA NA no no no no no no Pancreatic secretion Ovarian steroidogenesis 0.690434783 0.677865613 0.818532819 kegg kegg NA NA no no no no up up Pancreatic secretion Oxidative phosphorylation 0.643478261 0.720355731 0 kegg kegg NA NA no no no no no no Pancreatic secretion Pantothenate and CoA biosynthesis -0.446956522 -0.656126482 -0.553410553 kegg kegg NA NA no no no no no dn Pancreatic secretion "Parathyroid hormone synthesis, secretion and action" 0.719130435 0.716403162 0.637837838 kegg kegg NA NA no no no no no no Pancreatic secretion Pentose phosphate pathway 0 -0.510869565 0 kegg kegg NA NA no no no no no no Pancreatic secretion Peroxisome -0.740869565 -0.789525692 0 kegg kegg NA NA no no no no no no Pancreatic secretion Phagosome 0 -0.429841897 0 kegg kegg NA NA no no no no no no Pancreatic secretion Phospholipase D signaling pathway 0 0 0.435521236 kegg kegg NA NA no no no no up up Pancreatic secretion Platelet activation 0 0.617588933 0.406692407 kegg kegg NA NA no no no no no no Pancreatic secretion PPAR signaling pathway 0 -0.749011858 0 kegg kegg NA NA no no no no no no Pancreatic secretion Prevotella 0 0 0.524893876 acetate-producing kegg Genus NA 0.287 no no no no no no Pancreatic secretion Primary bile acid biosynthesis -0.526956522 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Prolactin signaling pathway 0 -0.542490119 0 kegg kegg NA NA no no no no no no Pancreatic secretion Propanoate metabolism -0.455652174 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Proteasome 0 0 -0.575289575 kegg kegg NA NA no no no no no no Pancreatic secretion Protein export 0 0.498023715 0 kegg kegg NA NA no no no no no no Pancreatic secretion Protein processing in endoplasmic reticulum 0 0.481225296 0 kegg kegg NA NA no no no no no no Pancreatic secretion Proximal tubule bicarbonate reclamation 0 0.5256917 0 kegg kegg NA NA no no no no no no Pancreatic secretion Pyrimidine metabolism -0.712173913 0 -0.447104247 kegg kegg NA NA no no no no no no Pancreatic secretion Pyruvate metabolism -0.451304348 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Rap1 signaling pathway 0 0.550395257 0 kegg kegg NA NA no no no no no no Pancreatic secretion Ras signaling pathway 0 0.580039526 0 yes kegg kegg NA NA no no no no up up Pancreatic secretion Regulation of lipolysis in adipocytes 0.783478261 0.735177866 0.904247104 kegg kegg NA NA no no no no no no Pancreatic secretion Relaxin signaling pathway 0.539130435 0 0.557786358 kegg kegg NA NA no no no no no no Pancreatic secretion Renin secretion 0.68 0.801383399 0.847619048 kegg kegg NA NA no no no no no no Pancreatic secretion Renin-angiotensin system 0 -0.519762846 0 kegg kegg NA NA no no no no no no Pancreatic secretion Retinol metabolism -0.55826087 0 -0.434491634 kegg kegg NA NA no no no no no no Pancreatic secretion Retrograde endocannabinoid signaling 0.406086957 0.736166008 0 kegg kegg NA NA no no no no no up Pancreatic secretion Ribosome 0.465217391 0.616600791 0 kegg kegg NA NA no no no no no no Pancreatic secretion RIG-I-like receptor signaling pathway 0 -0.583992095 0 kegg kegg NA NA no no no no no no Pancreatic secretion RNA degradation 0.407826087 0.598814229 0 kegg kegg NA NA no no no no no no Pancreatic secretion RNA transport -0.410434783 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Salivary secretion 0.677391304 0.597826087 0.649420849 kegg kegg NA NA no no no no no no Pancreatic secretion Serotonergic synapse 0.444347826 0 0.553153153 kegg kegg NA NA no no no no no no Pancreatic secretion SNARE interactions in vesicular transport -0.642608696 -0.5 0 kegg kegg NA NA no no no no no no Pancreatic secretion Sphingolipid metabolism 0 0 -0.473359073 kegg kegg NA NA no no no no no no Pancreatic secretion Starch and sucrose metabolism -0.603478261 -0.660079051 -0.668983269 kegg kegg NA NA no no no no no no Pancreatic secretion Steroid hormone biosynthesis 0 0 -0.540540541 kegg kegg NA NA no no no no no no Pancreatic secretion Synaptic vesicle cycle 0 -0.527667984 -0.537451737 kegg kegg NA NA no no no no up up Pancreatic secretion T cell receptor signaling pathway 0 -0.647233202 0 kegg kegg NA NA no no no no no no Pancreatic secretion TGF-beta signaling pathway 0.457391304 0.530632411 0 kegg kegg NA NA no no no no no no Pancreatic secretion Th1 and Th2 cell differentiation 0 -0.415019763 0 kegg kegg NA NA no no no no no no Pancreatic secretion Th17 cell differentiation 0 -0.490118577 0 kegg kegg NA NA no no no no no no Pancreatic secretion Thermogenesis 0.702608696 0.712450593 0 kegg kegg NA NA no no no no no no Pancreatic secretion Thiamine metabolism -0.451304348 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Thyroid hormone signaling pathway 0 0.701581028 0 kegg kegg NA NA no no no no no no Pancreatic secretion Thyroid hormone synthesis 0.620869565 0.79743083 0.68005148 kegg kegg NA NA no no no no no no Pancreatic secretion Tight junction 0 0.414031621 0 kegg kegg NA NA no no no no no no Pancreatic secretion TNF signaling pathway 0 -0.41798419 0 kegg kegg NA NA no no no no no no Pancreatic secretion Toll-like receptor signaling pathway 0 -0.558300395 0 yes kegg kegg NA NA no no no no no no Pancreatic secretion Tryptophan metabolism -0.616521739 0 -0.494208494 kegg kegg NA NA no no no no up no Pancreatic secretion Type II diabetes mellitus 0 0 -0.412612613 kegg kegg NA NA no no no no no no Pancreatic secretion Ubiquinone and other terpenoid-quinone biosynthesis -0.584347826 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Ubiquitin mediated proteolysis 0.648695652 0.608695652 0 kegg kegg NA NA no no no no no no Pancreatic secretion "Valine, leucine and isoleucine degradation" -0.588695652 0 0 kegg kegg NA NA no no no no no no Pancreatic secretion Vascular smooth muscle contraction 0.816521739 0.785573123 0.729472329 kegg kegg NA NA no no no no no no Pancreatic secretion Vasopressin-regulated water reabsorption 0.891304348 0.944664032 0.938481338 kegg kegg NA NA no no no no no no Pancreatic secretion Wnt signaling pathway 0.604347826 0.599802372 0 kegg kegg NA NA no no no no no no Pantothenate and CoA biosynthesis "Alanine, aspartate and glutamate metabolism" 0.68173913 0.82312253 0.705019305 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis alpha-Linolenic acid metabolism 0 0.753952569 0.491891892 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Arginine and proline metabolism 0.623478261 0.803359684 0.551608752 kegg kegg NA NA no no dn no up no Pantothenate and CoA biosynthesis Arginine biosynthesis 0.745217391 0.786561265 0.694980695 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Butanoate metabolism 0 -0.514822134 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Citrate cycle (TCA cycle) 0 -0.483201581 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Cysteine and methionine metabolism 0 -0.495059289 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Ether lipid metabolism 0 -0.466403162 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Fatty acid biosynthesis 0.78173913 0.852766798 0.73976834 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Fatty acid degradation 0.696521739 0.708498024 0.712741313 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Fructose and mannose metabolism 0 0 0.567052767 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Galactose metabolism 0 0.663043478 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Glutathione metabolism -0.575652174 -0.656126482 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis "Glycine, serine and threonine metabolism" -0.635652174 -0.455533597 0 kegg kegg NA NA no no dn no up no Pantothenate and CoA biosynthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.580869565 0.577075099 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.519762846 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate -0.446956522 -0.59486166 -0.445045045 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Glycosaminoglycan degradation 0 0.599802372 0 kegg kegg NA NA no no dn no no up Pantothenate and CoA biosynthesis Glyoxylate and dicarboxylate metabolism 0.635652174 0.794466403 0.756499356 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Histidine metabolism 0 0.447628458 0.472072072 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Mannose type O-glycan biosynthesis 0 0 -0.431145431 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis N-Glycan biosynthesis 0 -0.785573123 -0.432689833 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Nicotinate and nicotinamide metabolism 0.846086957 0.898221344 0.793564994 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis One carbon pool by folate 0 -0.47826087 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Oxidative phosphorylation 0 -0.76284585 -0.46975547 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Pentose and glucuronate interconversions 0 -0.645256917 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Pentose phosphate pathway 0.470434783 0.732213439 0.802831403 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Propanoate metabolism 0 -0.435770751 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Purine metabolism -0.511304348 -0.552371542 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Pyrimidine metabolism 0 -0.4743083 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Pyruvate metabolism 0 -0.591897233 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Starch and sucrose metabolism 0.655652174 0.899209486 0.578635779 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Thiamine metabolism 0 -0.519762846 0 kegg kegg NA NA no no dn no no no Pantothenate and CoA biosynthesis Various types of N-glycan biosynthesis 0 -0.671936759 0 kegg kegg NA NA no no dn no no no Parabacteroides Bacteroides 0 0.513628491 0 LPS-producing Genus Genus 4.19E-05 0.000267 no up up dn dn up "Parathyroid hormone synthesis, secretion and action" 2-Oxocarboxylic acid metabolism -0.492173913 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" ABC transporters -0.462608696 0 -0.409266409 kegg kegg NA NA no no no no up up "Parathyroid hormone synthesis, secretion and action" Adrenergic signaling in cardiomyocytes 0.746956522 0.824110672 0.702702703 kegg kegg NA NA no no no no no up "Parathyroid hormone synthesis, secretion and action" "Alanine, aspartate and glutamate metabolism" 0 -0.484189723 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Aldosterone synthesis and secretion 0.68 0.800395257 0.680823681 kegg kegg NA NA no no no no up up "Parathyroid hormone synthesis, secretion and action" alpha-Linolenic acid metabolism -0.607826087 -0.671936759 -0.684942085 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Amino sugar and nucleotide sugar metabolism -0.462608696 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Aminoacyl-tRNA biosynthesis -0.493043478 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" AMPK signaling pathway 0 0.558300395 0.431660232 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Apelin signaling pathway 0.487826087 0.657114625 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Apoptosis 0 -0.418972332 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Arginine and proline metabolism 0 -0.480237154 0 kegg kegg NA NA no no no no up no "Parathyroid hormone synthesis, secretion and action" Arginine biosynthesis -0.424347826 -0.440711462 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" beta-Alanine metabolism -0.712173913 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Biosynthesis of amino acids -0.656521739 -0.536561265 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Biosynthesis of unsaturated fatty acids -0.553043478 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Butanoate metabolism -0.519130435 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Butyricimonas 0.462684475 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no "Parathyroid hormone synthesis, secretion and action" Calcium signaling pathway 0.606086957 0.695652174 0.591505792 kegg kegg NA NA no no no no up up "Parathyroid hormone synthesis, secretion and action" cAMP signaling pathway 0.755652174 0 0.610810811 yes kegg kegg NA NA no no no no up up "Parathyroid hormone synthesis, secretion and action" Carbon metabolism -0.608695652 0 -0.429343629 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Cardiac muscle contraction 0.632173913 0.747035573 0 kegg kegg NA NA no no no no no up "Parathyroid hormone synthesis, secretion and action" Cell adhesion molecules -0.454782609 -0.535573123 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Cellular senescence 0 -0.448616601 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" cGMP-PKG signaling pathway 0 -0.463438735 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Circadian entrainment 0.447826087 0.514822134 0.658429858 kegg kegg NA NA no no no no up up "Parathyroid hormone synthesis, secretion and action" Circadian rhythm 0.580869565 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Complement and coagulation cascades -0.532173913 -0.588932806 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Cortisol synthesis and secretion 0.650434783 0.650197628 0.652252252 kegg kegg NA NA no no no no no up "Parathyroid hormone synthesis, secretion and action" Cytokine-cytokine receptor interaction 0 -0.486166008 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Dopaminergic synapse 0.749565217 0.68083004 0.718146718 kegg kegg NA NA no no no no up no "Parathyroid hormone synthesis, secretion and action" Drug metabolism - cytochrome P450 0 0 -0.434234234 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Drug metabolism - other enzymes -0.597391304 0 -0.50990991 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" EGFR tyrosine kinase inhibitor resistance 0.406086957 0.646245059 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Endocrine resistance 0.553913043 0.45256917 0.534362934 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Endocytosis 0 -0.553359684 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Estrogen signaling pathway 0 0 0.426254826 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Ether lipid metabolism 0.585217391 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Fatty acid biosynthesis -0.419130435 -0.527667984 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Fatty acid degradation -0.685217391 -0.602766798 -0.471042471 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Fatty acid elongation -0.580869565 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Fatty acid metabolism -0.766086957 -0.638339921 -0.434234234 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Fc epsilon RI signaling pathway 0 -0.498023715 -0.453024453 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Fc gamma R-mediated phagocytosis -0.631304348 -0.633399209 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Ferroptosis 0.449565217 0.423913043 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" FoxO signaling pathway 0 -0.581027668 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Fructose and mannose metabolism -0.523478261 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Galactose metabolism -0.689565217 -0.707509881 -0.494723295 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Glucagon signaling pathway 0.584347826 0.711462451 0.623938224 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Glutathione metabolism 0 0.589920949 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Glycerolipid metabolism 0 -0.524703557 0 kegg kegg NA NA no no no no no up "Parathyroid hormone synthesis, secretion and action" Glycolysis / Gluconeogenesis -0.500869565 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.442687747 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Glycosaminoglycan degradation 0 -0.483201581 -0.539253539 kegg kegg NA NA no no no no no up "Parathyroid hormone synthesis, secretion and action" Glyoxylate and dicarboxylate metabolism -0.580869565 -0.442687747 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" GnRH signaling pathway 0.633043478 0.733201581 0.745945946 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Hematopoietic cell lineage -0.529565217 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" HIF-1 signaling pathway 0 0.529644269 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Hippo signaling pathway - multiple species 0 -0.552371542 -0.493951094 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Histidine metabolism -0.5 0 -0.53976834 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Inflammatory mediator regulation of TRP channels 0.574782609 0.693675889 0.624967825 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Insulin secretion 0.553913043 0.723320158 0.666151866 yes kegg kegg NA NA no no no no up up "Parathyroid hormone synthesis, secretion and action" Insulin signaling pathway 0.417391304 0.60770751 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" JAK-STAT signaling pathway 0 -0.538537549 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Long-term depression 0.627826087 0.491106719 0.532046332 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Longevity regulating pathway 0.444347826 0 0.405920206 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Longevity regulating pathway - multiple species 0 -0.52173913 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Lysosome 0 0 -0.410810811 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" MAPK signaling pathway 0 -0.5 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Melanogenesis 0.517391304 0.781620553 0.732561133 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Metabolism of xenobiotics by cytochrome P450 0 0 -0.450707851 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Mitophagy - animal 0.789565217 0.830039526 0.587129987 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" mRNA surveillance pathway 0.657391304 0.57312253 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" mTOR signaling pathway 0.463478261 0.654150198 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Natural killer cell mediated cytotoxicity 0 -0.464426877 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Necroptosis 0.546956522 0.554347826 0.437065637 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Neuroactive ligand-receptor interaction 0 -0.635375494 0 kegg kegg NA NA no no no up up up "Parathyroid hormone synthesis, secretion and action" Neurotrophin signaling pathway 0.488695652 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Neutrophil extracellular trap formation -0.540869565 -0.539525692 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" NF-kappa B signaling pathway 0 -0.460474308 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Nicotinate and nicotinamide metabolism -0.482608696 -0.48715415 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" NOD-like receptor signaling pathway -0.49826087 -0.490118577 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Non-homologous end-joining -0.586956522 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Olfactory transduction 0 -0.492094862 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Oscillospira 0 -0.441699605 0 LPS-producing kegg Genus NA 0.62 no no no no no no "Parathyroid hormone synthesis, secretion and action" Osteoclast differentiation 0 -0.572134387 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Other glycan degradation 0 -0.423913043 -0.45019305 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Ovarian steroidogenesis 0 0.58201581 0.476705277 kegg kegg NA NA no no no no up up "Parathyroid hormone synthesis, secretion and action" Oxidative phosphorylation 0.643478261 0.774703557 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Pantothenate and CoA biosynthesis -0.439130435 -0.64229249 -0.410810811 kegg kegg NA NA no no no no no dn "Parathyroid hormone synthesis, secretion and action" Pentose phosphate pathway 0 -0.539525692 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Peroxisome -0.644347826 -0.638339921 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Phagosome -0.503478261 -0.505928854 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Phenylalanine metabolism -0.48173913 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" PPAR signaling pathway 0 -0.416007905 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Primary bile acid biosynthesis -0.466956522 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Prolactin signaling pathway 0 -0.464426877 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Protein export 0.49826087 0.488142292 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Protein processing in endoplasmic reticulum 0.446956522 0.453557312 0.456370656 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Pyramidobacter 0 0 0.405765075 kegg Genus NA 0.45 no no no no no no "Parathyroid hormone synthesis, secretion and action" Pyrimidine metabolism -0.675652174 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Regulation of lipolysis in adipocytes 0.570434783 0.530632411 0.577863578 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Relaxin signaling pathway 0.731304348 0 0.53976834 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Renin secretion 0 0.675889328 0.658944659 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Renin-angiotensin system 0 -0.532608696 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Retinol metabolism -0.519130435 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Retrograde endocannabinoid signaling 0 0.686758893 0 kegg kegg NA NA no no no no no up "Parathyroid hormone synthesis, secretion and action" Ribosome 0.693043478 0.791501976 0.488030888 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" RIG-I-like receptor signaling pathway 0 -0.429841897 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" RNA degradation 0.573043478 0.514822134 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" RNA transport 0 0.552371542 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Signaling pathways regulating pluripotency of stem cells 0.451304348 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" SNARE interactions in vesicular transport 0 -0.559288538 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Sphingolipid metabolism 0 0 -0.491119691 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Starch and sucrose metabolism -0.451304348 -0.584980237 -0.488288288 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Synaptic vesicle cycle 0 -0.506916996 0 kegg kegg NA NA no no no no up up "Parathyroid hormone synthesis, secretion and action" T cell receptor signaling pathway 0 -0.432806324 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" TGF-beta signaling pathway 0 0.462450593 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Thermogenesis 0.688695652 0.770750988 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Thyroid hormone synthesis 0.474782609 0.745059289 0.501158301 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" TNF signaling pathway 0.453913043 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Tryptophan metabolism -0.610434783 0 0 kegg kegg NA NA no no no no up no "Parathyroid hormone synthesis, secretion and action" Tyrosine metabolism -0.469565217 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Ubiquinone and other terpenoid-quinone biosynthesis -0.493043478 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Ubiquitin mediated proteolysis 0.777391304 0.805335968 0.584813385 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" "Valine, leucine and isoleucine degradation" -0.473043478 0 0 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Vascular smooth muscle contraction 0.756521739 0.675889328 0.676705277 kegg kegg NA NA no no no no no no "Parathyroid hormone synthesis, secretion and action" Wnt signaling pathway 0.503478261 0.416996047 0 kegg kegg NA NA no no no no no no Parkinson disease 2-Oxocarboxylic acid metabolism -0.473913043 0 0 kegg kegg NA NA no no no no no no Parkinson disease ABC transporters -0.512173913 0 0 kegg kegg NA NA no no no no up up Parkinson disease Adherens junction 0 0.563241107 0 kegg kegg NA NA no no no no no no Parkinson disease Adipocytokine signaling pathway 0.465217391 0 0.420849421 kegg kegg NA NA no no no no no no Parkinson disease Adrenergic signaling in cardiomyocytes 0.782608696 0.809288538 0 kegg kegg NA NA no no no no no up Parkinson disease AGE-RAGE signaling pathway in diabetic complications 0 -0.751976285 -0.530501931 kegg kegg NA NA no no no no no no Parkinson disease "Alanine, aspartate and glutamate metabolism" -0.576521739 -0.649209486 0 kegg kegg NA NA no no no no no no Parkinson disease Aldosterone synthesis and secretion 0.71826087 0.770750988 0.412097812 kegg kegg NA NA no no no no up up Parkinson disease Aldosterone-regulated sodium reabsorption 0 0 -0.740797941 kegg kegg NA NA no no no no no no Parkinson disease alpha-Linolenic acid metabolism -0.647826087 -0.709486166 -0.487001287 kegg kegg NA NA no no no no no no Parkinson disease Alzheimer disease 0.826086957 0.966403162 0 kegg kegg NA NA no no no no no no Parkinson disease Amino sugar and nucleotide sugar metabolism -0.585217391 0 0 kegg kegg NA NA no no no no no no Parkinson disease Aminoacyl-tRNA biosynthesis -0.599130435 0 0 kegg kegg NA NA no no no no no no Parkinson disease AMPK signaling pathway 0 0.51284585 0.519433719 kegg kegg NA NA no no no no no no Parkinson disease Apelin signaling pathway 0.437391304 0.717391304 0 kegg kegg NA NA no no no no no no Parkinson disease Apoptosis -0.469565217 -0.549407115 0 kegg kegg NA NA no no no no no no Parkinson disease Apoptosis - multiple species 0 -0.445652174 0 kegg kegg NA NA no no no no no no Parkinson disease Arginine and proline metabolism -0.470434783 -0.718379447 0 kegg kegg NA NA no no no no up no Parkinson disease Arginine biosynthesis -0.6 -0.587944664 0 kegg kegg NA NA no no no no no no Parkinson disease Autophagy - animal 0 -0.627470356 -0.597168597 kegg kegg NA NA no no no no no no Parkinson disease Axon guidance 0.44173913 0 0 kegg kegg NA NA no no no no up up Parkinson disease B cell receptor signaling pathway 0 -0.592885375 0 kegg kegg NA NA no no no no no no Parkinson disease Bacteroides -0.420869565 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Parkinson disease beta-Alanine metabolism -0.713913043 0 0 kegg kegg NA NA no no no no no no Parkinson disease Bile secretion 0.61826087 0.554347826 0.556756757 kegg kegg NA NA no no no no no no Parkinson disease Biosynthesis of amino acids -0.753043478 -0.595849802 0 kegg kegg NA NA no no no no no no Parkinson disease Biosynthesis of cofactors 0 0.416996047 0.420592021 kegg kegg NA NA no no no no no no Parkinson disease Biosynthesis of unsaturated fatty acids -0.592173913 0 0 kegg kegg NA NA no no no no no no Parkinson disease Butanoate metabolism -0.520869565 0 0 kegg kegg NA NA no no no no no no Parkinson disease C-type lectin receptor signaling pathway 0 -0.548418972 0 kegg kegg NA NA no no no no no no Parkinson disease Calcium signaling pathway 0.71826087 0.723320158 0 kegg kegg NA NA no no no no up up Parkinson disease cAMP signaling pathway 0.756521739 0 0 yes kegg kegg NA NA no no no no up up Parkinson disease Carbohydrate digestion and absorption 0 -0.470355731 -0.668725869 kegg kegg NA NA no no no no no no Parkinson disease Carbon metabolism -0.671304348 0 0 kegg kegg NA NA no no no no no no Parkinson disease Cardiac muscle contraction 0.786086957 0.924901186 0 kegg kegg NA NA no no no no no up Parkinson disease Cell adhesion molecules -0.493043478 -0.459486166 0 kegg kegg NA NA no no no no no no Parkinson disease Cellular senescence 0 -0.416996047 0 kegg kegg NA NA no no no no no no Parkinson disease cGMP-PKG signaling pathway 0 -0.614624506 -0.445045045 kegg kegg NA NA no no no no no no Parkinson disease Chemokine signaling pathway 0 -0.416996047 0 kegg kegg NA NA no no no no no no Parkinson disease Cholesterol metabolism 0 0 -0.411840412 yes kegg kegg NA NA no no no no no up Parkinson disease Cholinergic synapse 0 -0.457509881 -0.499099099 kegg kegg NA NA no no no no no no Parkinson disease Circadian entrainment 0.446956522 0.523715415 0.555727156 kegg kegg NA NA no no no no up up Parkinson disease Circadian rhythm 0.617391304 0 0 kegg kegg NA NA no no no no no no Parkinson disease Collinsella 0 0 0.423020121 kegg Genus NA 0.128 no no no no no no Parkinson disease Complement and coagulation cascades -0.584347826 -0.62055336 0 kegg kegg NA NA no no no no no no Parkinson disease Cortisol synthesis and secretion 0.623478261 0.480237154 0.472586873 kegg kegg NA NA no no no no no up Parkinson disease Cushing syndrome 0.608695652 0.501976285 0 kegg kegg NA NA no no no no no up Parkinson disease Cytokine-cytokine receptor interaction 0 -0.46541502 0 kegg kegg NA NA no no no no no no Parkinson disease Dopaminergic synapse 0.742608696 0.674901186 0 kegg kegg NA NA no no no no up no Parkinson disease Drug metabolism - cytochrome P450 0 0.423913043 0 kegg kegg NA NA no no no no no no Parkinson disease Drug metabolism - other enzymes -0.533043478 0.463438735 0 kegg kegg NA NA no no no no no no Parkinson disease EGFR tyrosine kinase inhibitor resistance 0 0.652173913 0 kegg kegg NA NA no no no no no no Parkinson disease Endocrine and other factor-regulated calcium reabsorption 0.648695652 0.807312253 0.571428571 kegg kegg NA NA no no no no no no Parkinson disease Endocrine resistance 0.5 0 0 kegg kegg NA NA no no no no no no Parkinson disease Endocytosis -0.419130435 -0.481225296 0 kegg kegg NA NA no no no no no no Parkinson disease ErbB signaling pathway 0 -0.459486166 -0.588416988 kegg kegg NA NA no no no no no no Parkinson disease Ether lipid metabolism 0.774782609 0.41798419 0 kegg kegg NA NA no no no no no no Parkinson disease Fat digestion and absorption -0.612173913 -0.562252964 -0.475160875 yes kegg kegg NA NA no no no no up up Parkinson disease Fatty acid biosynthesis -0.595652174 -0.730237154 0 kegg kegg NA NA no no no no no no Parkinson disease Fatty acid degradation -0.847826087 -0.794466403 0 kegg kegg NA NA no no no no no no Parkinson disease Fatty acid elongation -0.590434783 0 0 kegg kegg NA NA no no no no no no Parkinson disease Fatty acid metabolism -0.912173913 -0.779644269 0 kegg kegg NA NA no no no no no no Parkinson disease Fc epsilon RI signaling pathway 0 -0.66798419 -0.590733591 kegg kegg NA NA no no no no no no Parkinson disease Fc gamma R-mediated phagocytosis -0.72173913 -0.633399209 0 kegg kegg NA NA no no no no no no Parkinson disease Ferroptosis 0.46173913 0 0.624967825 kegg kegg NA NA no no no no no no Parkinson disease Focal adhesion 0 0.43083004 0 kegg kegg NA NA no no no no up up Parkinson disease FoxO signaling pathway 0 -0.742094862 0 kegg kegg NA NA no no no no no no Parkinson disease Fructose and mannose metabolism -0.635652174 -0.516798419 0 kegg kegg NA NA no no no no no no Parkinson disease GABAergic synapse -0.468695652 -0.556324111 0 kegg kegg NA NA no no no no up up Parkinson disease Galactose metabolism -0.766956522 -0.785573123 -0.465122265 kegg kegg NA NA no no no no no no Parkinson disease Gastric acid secretion 0 0.656126482 0 kegg kegg NA NA no no no no no no Parkinson disease Glucagon signaling pathway 0.524347826 0.761857708 0 kegg kegg NA NA no no no no no no Parkinson disease Glutathione metabolism 0 0.708498024 0.558043758 kegg kegg NA NA no no no no no no Parkinson disease Glycerolipid metabolism 0 -0.62055336 0 kegg kegg NA NA no no no no no up Parkinson disease "Glycine, serine and threonine metabolism" 0 0.464426877 0.407207207 kegg kegg NA NA no no no no up no Parkinson disease Glycolysis / Gluconeogenesis -0.612173913 0 0 kegg kegg NA NA no no no no no no Parkinson disease Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.685770751 -0.442985843 kegg kegg NA NA no no no no no no Parkinson disease Glycosaminoglycan biosynthesis - keratan sulfate 0.587826087 0 0 kegg kegg NA NA no no no no no no Parkinson disease Glycosaminoglycan degradation 0 -0.459486166 -0.56010296 kegg kegg NA NA no no no no no up Parkinson disease Glycosphingolipid biosynthesis - lacto and neolacto series 0.424347826 0 0 kegg kegg NA NA no no no no no no Parkinson disease Glyoxylate and dicarboxylate metabolism -0.713043478 -0.596837945 0 kegg kegg NA NA no no no no no no Parkinson disease GnRH secretion 0 0 -0.433976834 kegg kegg NA NA no no no no up up Parkinson disease GnRH signaling pathway 0.603478261 0.546442688 0 kegg kegg NA NA no no no no no no Parkinson disease Hematopoietic cell lineage -0.428695652 0 0 kegg kegg NA NA no no no no no no Parkinson disease HIF-1 signaling pathway 0 0.62055336 0 kegg kegg NA NA no no no no no no Parkinson disease Hippo signaling pathway 0 0.533596838 0 kegg kegg NA NA no no no no no no Parkinson disease Hippo signaling pathway - multiple species 0 -0.717391304 -0.632947233 kegg kegg NA NA no no no no no no Parkinson disease Histidine metabolism -0.523478261 0 -0.432175032 kegg kegg NA NA no no no no no no Parkinson disease IL-17 signaling pathway 0 -0.495059289 0 kegg kegg NA NA no no no no no no Parkinson disease Inflammatory mediator regulation of TRP channels 0.63826087 0.764822134 0 kegg kegg NA NA no no no no no no Parkinson disease Inositol phosphate metabolism -0.431304348 -0.485177866 0 kegg kegg NA NA no no no no no no Parkinson disease Insulin resistance 0 -0.48715415 0 kegg kegg NA NA no no no no no no Parkinson disease Insulin secretion 0.571304348 0.583003953 0.406177606 yes kegg kegg NA NA no no no no up up Parkinson disease Insulin signaling pathway 0 0.661067194 0 kegg kegg NA NA no no no no no no Parkinson disease JAK-STAT signaling pathway -0.445217391 -0.681818182 0 kegg kegg NA NA no no no no no no Parkinson disease Long-term depression 0.671304348 0 0 kegg kegg NA NA no no no no no no Parkinson disease Longevity regulating pathway 0.452173913 0 0.508622909 kegg kegg NA NA no no no no no no Parkinson disease Mannose type O-glycan biosynthesis 0.533043478 0 0 kegg kegg NA NA no no no no no no Parkinson disease MAPK signaling pathway 0 -0.694664032 -0.581467181 kegg kegg NA NA no no no no no no Parkinson disease Melanogenesis 0.60173913 0.820158103 0.480823681 kegg kegg NA NA no no no no no no Parkinson disease Mineral absorption 0.725217391 0.673913043 0.764221364 kegg kegg NA NA no no no no no no Parkinson disease Mitophagy - animal 0.882608696 0.916996047 0.83037323 kegg kegg NA NA no no no no no no Parkinson disease mRNA surveillance pathway 0.72173913 0.592885375 0 kegg kegg NA NA no no no no no no Parkinson disease mTOR signaling pathway 0.414782609 0.656126482 0 kegg kegg NA NA no no no no no no Parkinson disease Mucin type O-glycan biosynthesis 0 -0.473320158 0 kegg kegg NA NA no no no no no no Parkinson disease N-Glycan biosynthesis 0 0.445652174 0 kegg kegg NA NA no no no no no no Parkinson disease Natural killer cell mediated cytotoxicity 0 -0.418972332 0 kegg kegg NA NA no no no no no no Parkinson disease Necroptosis 0.583478261 0.456521739 0.674903475 kegg kegg NA NA no no no no no no Parkinson disease Neuroactive ligand-receptor interaction 0 -0.538537549 0 kegg kegg NA NA no no no up up up Parkinson disease Neurotrophin signaling pathway 0.483478261 0 0 kegg kegg NA NA no no no no no no Parkinson disease Neutrophil extracellular trap formation -0.572173913 -0.518774704 0 kegg kegg NA NA no no no no no no Parkinson disease NF-kappa B signaling pathway -0.430434783 -0.637351779 0 kegg kegg NA NA no no no no no no Parkinson disease Nicotinate and nicotinamide metabolism -0.569565217 -0.669960474 0 kegg kegg NA NA no no no no no no Parkinson disease Nitrogen metabolism -0.417391304 -0.485177866 0 kegg kegg NA NA no no no no no no Parkinson disease NOD-like receptor signaling pathway -0.613913043 -0.671936759 0 kegg kegg NA NA no no no no no no Parkinson disease Non-alcoholic fatty liver disease 0.853043478 0.949604743 0.599485199 kegg kegg NA NA no no no no no no Parkinson disease Non-homologous end-joining -0.670434783 0 0 kegg kegg NA NA no no no no no no Parkinson disease Notch signaling pathway 0 0 -0.403861004 kegg kegg NA NA no no no no no no Parkinson disease Olfactory transduction 0 -0.556324111 0 kegg kegg NA NA no no no no no no Parkinson disease Oscillospira 0 -0.493083004 0 LPS-producing kegg Genus NA 0.62 no no no no no no Parkinson disease Osteoclast differentiation -0.460869565 -0.688735178 0 kegg kegg NA NA no no no no no no Parkinson disease Other glycan degradation 0 -0.527667984 -0.536164736 kegg kegg NA NA no no no no no no Parkinson disease Ovarian steroidogenesis 0.426956522 0.437747036 0.49034749 kegg kegg NA NA no no no no up up Parkinson disease Oxidative phosphorylation 0.808695652 0.955533597 0.434749035 kegg kegg NA NA no no no no no no Parkinson disease Pancreatic secretion 0.773043478 0.692687747 0.461261261 kegg kegg NA NA no no no no no no Parkinson disease Pantothenate and CoA biosynthesis -0.570434783 -0.736166008 0 kegg kegg NA NA no no no no no dn Parkinson disease "Parathyroid hormone synthesis, secretion and action" 0.860869565 0.833003953 0.623938224 kegg kegg NA NA no no no no no no Parkinson disease Pentose and glucuronate interconversions 0 0.419960474 0 kegg kegg NA NA no no no no no no Parkinson disease Pentose phosphate pathway -0.436521739 -0.572134387 0 kegg kegg NA NA no no no no no no Parkinson disease Peroxisome -0.739130435 -0.656126482 0 kegg kegg NA NA no no no no no no Parkinson disease Phagosome -0.514782609 -0.470355731 0 kegg kegg NA NA no no no no no no Parkinson disease Phosphatidylinositol signaling system 0.430434783 0 0 kegg kegg NA NA no no no no no no Parkinson disease Phospholipase D signaling pathway 0 -0.469367589 0 kegg kegg NA NA no no no no up up Parkinson disease Phototransduction 0 0.472332016 0 kegg kegg NA NA no no no no no no Parkinson disease Platelet activation 0 0.469367589 0 kegg kegg NA NA no no no no no no Parkinson disease Porphyrin and chlorophyll metabolism 0 0.492094862 0.482368082 kegg kegg NA NA no no no no no no Parkinson disease PPAR signaling pathway 0 -0.538537549 0 kegg kegg NA NA no no no no no no Parkinson disease Primary bile acid biosynthesis -0.475652174 0 0 kegg kegg NA NA no no no no no no Parkinson disease Prolactin signaling pathway 0 -0.611660079 -0.416473616 kegg kegg NA NA no no no no no no Parkinson disease Proteasome 0 0.438735178 0 kegg kegg NA NA no no no no no no Parkinson disease Protein digestion and absorption -0.793043478 -0.848814229 -0.663063063 yes kegg kegg NA NA no no no no up up Parkinson disease Protein export 0.529565217 0.700592885 0 kegg kegg NA NA no no no no no no Parkinson disease Protein processing in endoplasmic reticulum 0.413043478 0.567193676 0.610553411 kegg kegg NA NA no no no no no no Parkinson disease Purine metabolism 0 0.5 0.550579151 kegg kegg NA NA no no no no no no Parkinson disease Pyrimidine metabolism -0.697391304 0 0 kegg kegg NA NA no no no no no no Parkinson disease Pyruvate metabolism 0 0.510869565 0 kegg kegg NA NA no no no no no no Parkinson disease Regulation of lipolysis in adipocytes 0.52 0.425889328 0.440669241 kegg kegg NA NA no no no no no no Parkinson disease Relaxin signaling pathway 0.691304348 0 0 kegg kegg NA NA no no no no no no Parkinson disease Renin secretion 0.484347826 0.789525692 0.579150579 kegg kegg NA NA no no no no no no Parkinson disease Renin-angiotensin system 0 -0.610671937 -0.447876448 kegg kegg NA NA no no no no no no Parkinson disease Retinol metabolism -0.614782609 0 0 kegg kegg NA NA no no no no no no Parkinson disease Retrograde endocannabinoid signaling 0.55826087 0.882411067 0 kegg kegg NA NA no no no no no up Parkinson disease Ribosome 0.826086957 0.863636364 0.588159588 kegg kegg NA NA no no no no no no Parkinson disease RIG-I-like receptor signaling pathway 0 -0.576086957 0 kegg kegg NA NA no no no no no no Parkinson disease RNA degradation 0.677391304 0.567193676 0 kegg kegg NA NA no no no no no no Parkinson disease RNA polymerase 0 0.508893281 0 kegg kegg NA NA no no no no no no Parkinson disease RNA transport 0 0.526679842 0 kegg kegg NA NA no no no no no no Parkinson disease Ruminococcus 0 0.42446886 0 kegg Genus NA 0.0679 no no no no no dn Parkinson disease Signaling pathways regulating pluripotency of stem cells 0.428695652 0 0 kegg kegg NA NA no no no no no no Parkinson disease SNARE interactions in vesicular transport 0 -0.677865613 0 kegg kegg NA NA no no no no no no Parkinson disease Sphingolipid metabolism 0 0 -0.565508366 kegg kegg NA NA no no no no no no Parkinson disease Sphingolipid signaling pathway 0 0 -0.587902188 kegg kegg NA NA no no no no no no Parkinson disease Starch and sucrose metabolism -0.580869565 -0.766798419 0 kegg kegg NA NA no no no no no no Parkinson disease Synaptic vesicle cycle 0 -0.528656126 0 kegg kegg NA NA no no no no up up Parkinson disease T cell receptor signaling pathway 0 -0.473320158 0 kegg kegg NA NA no no no no no no Parkinson disease TGF-beta signaling pathway 0.644347826 0.57312253 0 kegg kegg NA NA no no no no no no Parkinson disease Th1 and Th2 cell differentiation 0 -0.451581028 0 kegg kegg NA NA no no no no no no Parkinson disease Th17 cell differentiation 0 -0.448616601 0 kegg kegg NA NA no no no no no no Parkinson disease Thermogenesis 0.855652174 0.93972332 0.512483912 kegg kegg NA NA no no no no no no Parkinson disease Thyroid hormone signaling pathway 0 0.549407115 0 kegg kegg NA NA no no no no no no Parkinson disease Thyroid hormone synthesis 0.545217391 0.662055336 0.58970399 kegg kegg NA NA no no no no no no Parkinson disease Tight junction 0 0.479249012 0 kegg kegg NA NA no no no no no no Parkinson disease TNF signaling pathway 0 -0.496047431 0 kegg kegg NA NA no no no no no no Parkinson disease Toll-like receptor signaling pathway 0 -0.562252964 0 yes kegg kegg NA NA no no no no no no Parkinson disease Tryptophan metabolism -0.582608696 0 0 kegg kegg NA NA no no no no up no Parkinson disease Type II diabetes mellitus 0 -0.589920949 -0.64015444 kegg kegg NA NA no no no no no no Parkinson disease Tyrosine metabolism -0.409565217 0 0 kegg kegg NA NA no no no no no no Parkinson disease Ubiquinone and other terpenoid-quinone biosynthesis -0.428695652 0 0 kegg kegg NA NA no no no no no no Parkinson disease Ubiquitin mediated proteolysis 0.883478261 0.919960474 0.841956242 kegg kegg NA NA no no no no no no Parkinson disease "Valine, leucine and isoleucine degradation" -0.466956522 0 0 kegg kegg NA NA no no no no no no Parkinson disease Vascular smooth muscle contraction 0.897391304 0.840909091 0.508880309 kegg kegg NA NA no no no no no no Parkinson disease Vasopressin-regulated water reabsorption 0.67826087 0.759881423 0.623938224 kegg kegg NA NA no no no no no no Parkinson disease VEGF signaling pathway 0 -0.440711462 -0.515830116 kegg kegg NA NA no no no no no no Parkinson disease Vitamin digestion and absorption 0.469565217 0 0 kegg kegg NA NA no no no no no no Parkinson disease Wnt signaling pathway 0.666956522 0.5256917 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection ABC transporters 0 0 -0.409009009 kegg kegg NA NA no no no no up up Pathogenic Escherichia coli infection Adherens junction 0.473043478 0 0.646074646 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Adrenergic signaling in cardiomyocytes 0 -0.519762846 0 kegg kegg NA NA no no no no no up Pathogenic Escherichia coli infection AGE-RAGE signaling pathway in diabetic complications 0 0.434782609 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Aldosterone synthesis and secretion -0.57826087 -0.725296443 0 kegg kegg NA NA no no no no up up Pathogenic Escherichia coli infection alpha-Linolenic acid metabolism 0.572173913 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Alzheimer disease 0 -0.419960474 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Aminoacyl-tRNA biosynthesis 0 0 -0.504504505 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Amphetamine addiction -0.523478261 -0.788537549 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection AMPK signaling pathway 0 -0.62055336 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Amyotrophic lateral sclerosis 0 -0.499011858 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Antifolate resistance 0 -0.462450593 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Antigen processing and presentation 0.479130435 0.490118577 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Apelin signaling pathway -0.500869565 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Apoptosis 0.817391304 0.685770751 0.764736165 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Apoptosis - multiple species -0.516521739 -0.492094862 -0.555727156 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Arginine and proline metabolism 0.457391304 0.473320158 0 kegg kegg NA NA no no no no up no Pathogenic Escherichia coli infection Arginine biosynthesis 0 0.467391304 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Autophagy - other 0 0 -0.563191763 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection B cell receptor signaling pathway 0 0.559288538 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Bacterial invasion of epithelial cells 0.62 0 0.702960103 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Basal transcription factors -0.546956522 -0.774703557 -0.73951094 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Base excision repair -0.48 -0.679841897 -0.593822394 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Biosynthesis of amino acids 0.587826087 0.821146245 0.685199485 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Biosynthesis of cofactors 0 -0.730237154 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection C-type lectin receptor signaling pathway 0 0.537549407 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Calcium signaling pathway -0.522608696 0 0 kegg kegg NA NA no no no no up up Pathogenic Escherichia coli infection Carbon metabolism 0.491304348 0.645256917 0.649163449 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Cell adhesion molecules 0.513913043 0.828063241 0.592535393 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Cell cycle -0.579130435 -0.769762846 -0.662548263 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Cellular senescence 0.475652174 0.725296443 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection cGMP-PKG signaling pathway 0 0.778656126 0.401544402 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Chemokine signaling pathway 0.445217391 0.683794466 0.638095238 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Cholesterol metabolism 0 0.756916996 0 yes kegg kegg NA NA no no no no no up Pathogenic Escherichia coli infection Circadian rhythm -0.497391304 -0.773715415 -0.703474903 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Cocaine addiction 0 -0.56027668 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Complement and coagulation cascades 0.582608696 0.699604743 0.714543115 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Cortisol synthesis and secretion -0.406086957 -0.727272727 0 kegg kegg NA NA no no no no no up Pathogenic Escherichia coli infection Cushing syndrome -0.50173913 -0.825098814 0 kegg kegg NA NA no no no no no up Pathogenic Escherichia coli infection Cytokine-cytokine receptor interaction 0 0.416007905 0.445302445 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Cytosolic DNA-sensing pathway 0.476521739 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection DNA replication 0 -0.554347826 -0.534362934 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Dopaminergic synapse 0 -0.501976285 0 kegg kegg NA NA no no no no up no Pathogenic Escherichia coli infection EGFR tyrosine kinase inhibitor resistance -0.435652174 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Endocrine and other factor-regulated calcium reabsorption 0 -0.562252964 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Endocrine resistance -0.476521739 -0.62055336 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Endocytosis 0.566956522 0.827075099 0.482368082 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Epithelial cell signaling in Helicobacter pylori infection 0.655652174 0.766798419 0.555212355 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Estrogen signaling pathway 0 -0.494071146 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Ether lipid metabolism 0 -0.743083004 -0.471557272 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Eubacterium 0 0 -0.47284869 kegg Genus NA 0.0692 no no no no no no Pathogenic Escherichia coli infection Fanconi anemia pathway 0 -0.693675889 -0.67001287 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Fat digestion and absorption 0.453913043 0.553359684 0.503732304 yes kegg kegg NA NA no no no no up up Pathogenic Escherichia coli infection Fatty acid biosynthesis 0 0.485177866 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Fc epsilon RI signaling pathway 0 0.60770751 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Fc gamma R-mediated phagocytosis 0.656521739 0.765810277 0.564736165 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Focal adhesion 0.453913043 0 0.518918919 kegg kegg NA NA no no no no up up Pathogenic Escherichia coli infection Galactose metabolism 0.470434783 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Gastric acid secretion 0 0 0.543629344 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Glucagon signaling pathway -0.675652174 -0.761857708 -0.542342342 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Glutathione metabolism 0 -0.518774704 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Glycerophospholipid metabolism -0.453913043 -0.492094862 -0.578893179 kegg kegg NA NA no no no no no up Pathogenic Escherichia coli infection "Glycine, serine and threonine metabolism" 0 -0.638339921 0 kegg kegg NA NA no no no no up no Pathogenic Escherichia coli infection Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.427826087 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Glycosaminoglycan biosynthesis - keratan sulfate -0.423478261 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Glycosaminoglycan degradation 0.482608696 0.531620553 0 kegg kegg NA NA no no no no no up Pathogenic Escherichia coli infection Glycosphingolipid biosynthesis - ganglio series 0 -0.445652174 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.405217391 -0.704545455 -0.438352638 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Glyoxylate and dicarboxylate metabolism 0 0.509881423 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection GnRH signaling pathway -0.534782609 -0.635375494 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Hedgehog signaling pathway -0.510434783 -0.590909091 -0.562162162 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection HIF-1 signaling pathway -0.44 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Hippo signaling pathway 0 0 0.470527671 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Homologous recombination 0 -0.623517787 -0.703732304 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Huntington disease 0 -0.435770751 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection IL-17 signaling pathway 0.519130435 0.738142292 0.474646075 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Inflammatory mediator regulation of TRP channels -0.473043478 -0.586956522 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Inositol phosphate metabolism 0 0 -0.447104247 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Insulin resistance 0 0 -0.469240669 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Insulin secretion -0.446086957 -0.693675889 0 yes kegg kegg NA NA no no no no up up Pathogenic Escherichia coli infection Insulin signaling pathway -0.524347826 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Leukocyte transendothelial migration 0.626086957 0.570158103 0.88005148 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Long-term potentiation -0.506956522 0 0 kegg kegg NA NA no no no no no up Pathogenic Escherichia coli infection Longevity regulating pathway -0.449565217 -0.450592885 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Lysine degradation 0 -0.623517787 -0.611840412 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Lysosome 0.53826087 0.812252964 0.583011583 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Mannose type O-glycan biosynthesis 0 -0.493083004 -0.560617761 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Maturity onset diabetes of the young 0 -0.539525692 0 kegg kegg NA NA no no no no up no Pathogenic Escherichia coli infection Melanogenesis 0 -0.551383399 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Mismatch repair 0 -0.492094862 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Mitophagy - animal 0 -0.446640316 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Morphine addiction 0 -0.493083004 0 kegg kegg NA NA no no no no up up Pathogenic Escherichia coli infection mRNA surveillance pathway -0.516521739 -0.711462451 -0.642471042 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection mTOR signaling pathway -0.468695652 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Mucin type O-glycan biosynthesis 0 0 -0.459202059 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection N-Glycan biosynthesis -0.639130435 -0.544466403 -0.466151866 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Natural killer cell mediated cytotoxicity 0.642608696 0.806324111 0.445302445 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Neuroactive ligand-receptor interaction 0.615652174 0.75 0.612612613 kegg kegg NA NA no no no up up up Pathogenic Escherichia coli infection Neurotrophin signaling pathway 0 0.477272727 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Neutrophil extracellular trap formation 0.777391304 0.774703557 0.813127413 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Nicotinate and nicotinamide metabolism 0.407826087 0.509881423 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Nicotine addiction 0 -0.419960474 0 kegg kegg NA NA no no no no up up Pathogenic Escherichia coli infection NOD-like receptor signaling pathway 0.491304348 0.515810277 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Nucleotide excision repair 0 -0.644268775 -0.527413127 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Odoribacter 0 0.484399702 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Pathogenic Escherichia coli infection Olfactory transduction 0 0.67687747 0.521235521 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection One carbon pool by folate 0 -0.640316206 -0.515057915 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Oocyte meiosis -0.431304348 0 -0.429086229 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Osteoclast differentiation 0.707826087 0.701581028 0.522007722 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Other types of O-glycan biosynthesis -0.572173913 -0.748023715 -0.737194337 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Ovarian steroidogenesis 0 -0.431818182 0 kegg kegg NA NA no no no no up up Pathogenic Escherichia coli infection Oxytocin signaling pathway 0.460869565 0 0.690862291 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection p53 signaling pathway -0.620869565 -0.610671937 -0.849420849 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Pancreatic secretion 0 -0.428853755 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Pantothenate and CoA biosynthesis 0.462608696 0.429841897 0 kegg kegg NA NA no no no no no dn Pathogenic Escherichia coli infection "Parathyroid hormone synthesis, secretion and action" 0 -0.421936759 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Parkinson disease -0.406086957 -0.435770751 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Pathways of neurodegeneration - multiple diseases -0.42173913 -0.469367589 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Pentose and glucuronate interconversions 0 -0.427865613 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Pentose phosphate pathway 0.753043478 0.850790514 0.55032175 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Phagosome 0.626086957 0.916007905 0.78970399 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Phosphatidylinositol signaling system -0.652173913 -0.583003953 -0.645559846 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Platelet activation 0 0 0.724581725 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Platinum drug resistance -0.519130435 -0.542490119 -0.610810811 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Porphyrin and chlorophyll metabolism 0 -0.590909091 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection PPAR signaling pathway 0 0.645256917 0.504504505 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Progesterone-mediated oocyte maturation 0 -0.437747036 -0.454826255 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Prolactin signaling pathway 0 0.444664032 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Protein export -0.64173913 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Protein processing in endoplasmic reticulum -0.515652174 -0.631422925 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Proximal tubule bicarbonate reclamation 0 -0.491106719 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Purine metabolism -0.409565217 -0.644268775 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Pyrimidine metabolism 0 -0.513833992 -0.45997426 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Rap1 signaling pathway 0.53826087 0 0.795366795 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Ras signaling pathway 0 0 -0.494465894 yes kegg kegg NA NA no no no no up up Pathogenic Escherichia coli infection Regulation of actin cytoskeleton 0.530434783 0 0.468211068 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Regulation of lipolysis in adipocytes 0 -0.448616601 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Renin secretion 0 -0.502964427 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Renin-angiotensin system 0.453913043 0.746047431 0.420849421 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Ribosome -0.588695652 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Ribosome biogenesis in eukaryotes -0.630434783 -0.721343874 -0.696525097 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection RNA degradation -0.566956522 -0.581027668 -0.588416988 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection RNA polymerase -0.694782609 -0.751976285 -0.533333333 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Selenocompound metabolism -0.409565217 -0.625494071 -0.655341055 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Serotonergic synapse 0 0 0.449163449 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Signaling pathways regulating pluripotency of stem cells -0.445217391 -0.457509881 -0.54002574 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Sphingolipid metabolism 0.482608696 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Sphingolipid signaling pathway 0 0.651185771 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Spinocerebellar ataxia -0.442608696 -0.561264822 -0.45019305 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Spliceosome -0.484347826 -0.566205534 -0.692149292 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Starch and sucrose metabolism 0.643478261 0.422924901 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Steroid biosynthesis -0.580869565 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Synaptic vesicle cycle 0.42 0.746047431 0 kegg kegg NA NA no no no no up up Pathogenic Escherichia coli infection Synthesis and degradation of ketone bodies 0 -0.570158103 -0.418275418 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Taste transduction 0 -0.598814229 -0.466924067 kegg kegg NA NA no no no no no up Pathogenic Escherichia coli infection Taurine and hypotaurine metabolism 0 0 -0.44041184 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Terpenoid backbone biosynthesis -0.436521739 -0.506916996 -0.510682111 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection TGF-beta signaling pathway -0.473913043 0 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Th1 and Th2 cell differentiation 0 0.420948617 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Th17 cell differentiation 0 0.414031621 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Thyroid hormone synthesis -0.514782609 -0.579051383 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Tight junction 0.468695652 0 0.619305019 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Toll-like receptor signaling pathway 0 0.58201581 0.457657658 yes kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Type I diabetes mellitus 0 0.770750988 0.471814672 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.438735178 -0.426769627 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Ubiquitin mediated proteolysis -0.452173913 -0.585968379 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Various types of N-glycan biosynthesis -0.491304348 -0.460474308 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Vasopressin-regulated water reabsorption 0 -0.51284585 0 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Vibrio cholerae infection 0 0 0.673359073 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Viral protein interaction with cytokine and cytokine receptor 0 0.443675889 0.453281853 kegg kegg NA NA no no no no no no Pathogenic Escherichia coli infection Wnt signaling pathway 0 -0.571146245 -0.487001287 kegg kegg NA NA no no no no no no Pathways in cancer 2-Oxocarboxylic acid metabolism -0.736521739 -0.42687747 -0.447361647 kegg kegg NA NA no no no no no no Pathways in cancer ABC transporters 0 0.540513834 0 kegg kegg NA NA no no no no up up Pathways in cancer Adherens junction -0.426086957 -0.59486166 -0.412355212 kegg kegg NA NA no no no no no no Pathways in cancer Adipocytokine signaling pathway 0 0.477272727 0 kegg kegg NA NA no no no no no no Pathways in cancer Adrenergic signaling in cardiomyocytes 0.50173913 0 0 kegg kegg NA NA no no no no no up Pathways in cancer African trypanosomiasis 0.452173913 0.43972332 0 kegg kegg NA NA no no no no no no Pathways in cancer AGE-RAGE signaling pathway in diabetic complications 0 0.622529644 0.477734878 kegg kegg NA NA no no no no no no Pathways in cancer "Alanine, aspartate and glutamate metabolism" 0 0.470355731 0 kegg kegg NA NA no no no no no no Pathways in cancer Aldosterone synthesis and secretion 0.444347826 0 0 kegg kegg NA NA no no no no up up Pathways in cancer Aldosterone-regulated sodium reabsorption 0.536521739 0.448616601 0 kegg kegg NA NA no no no no no no Pathways in cancer alpha-Linolenic acid metabolism -0.64 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Alzheimer disease 0.633913043 -0.459486166 0 kegg kegg NA NA no no no no no no Pathways in cancer Amino sugar and nucleotide sugar metabolism -0.542608696 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Amoebiasis 0 0.527667984 0 kegg kegg NA NA no no no no no no Pathways in cancer Amyotrophic lateral sclerosis 0.531304348 -0.455533597 0 kegg kegg NA NA no no no no no no Pathways in cancer Antigen processing and presentation 0 -0.43083004 -0.424195624 kegg kegg NA NA no no no no no no Pathways in cancer Apelin signaling pathway 0 -0.526679842 0 kegg kegg NA NA no no no no no no Pathways in cancer Apoptosis - multiple species 0 0.48715415 0.454568855 kegg kegg NA NA no no no no no no Pathways in cancer Arachidonic acid metabolism -0.536521739 0 -0.463063063 kegg kegg NA NA no no no no no no Pathways in cancer Arginine and proline metabolism 0 0.455533597 0 kegg kegg NA NA no no no no up no Pathways in cancer Arginine biosynthesis 0 0.431818182 0 kegg kegg NA NA no no no no no no Pathways in cancer Autophagy - animal 0.56 0.691699605 0 kegg kegg NA NA no no no no no no Pathways in cancer Autophagy - other 0.606086957 0.494071146 0.551608752 kegg kegg NA NA no no no no no no Pathways in cancer Axon guidance 0.510434783 0 0 kegg kegg NA NA no no no no up up Pathways in cancer B cell receptor signaling pathway 0 0.561264822 0 kegg kegg NA NA no no no no no no Pathways in cancer Bacterial invasion of epithelial cells -0.572173913 -0.643280632 -0.511711712 kegg kegg NA NA no no no no no no Pathways in cancer Bacteroides 0 -0.479249012 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Pathways in cancer Basal transcription factors 0.423478261 0 0 kegg kegg NA NA no no no no no no Pathways in cancer beta-Alanine metabolism -0.726956522 -0.561264822 -0.475675676 kegg kegg NA NA no no no no no no Pathways in cancer Biosynthesis of amino acids -0.73826087 0 -0.467696268 kegg kegg NA NA no no no no no no Pathways in cancer Biosynthesis of cofactors -0.46173913 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Butanoate metabolism -0.627826087 -0.580039526 0 kegg kegg NA NA no no no no no no Pathways in cancer C-type lectin receptor signaling pathway 0.497391304 0.506916996 0 kegg kegg NA NA no no no no no no Pathways in cancer Calcium signaling pathway 0.59826087 0 0.480823681 kegg kegg NA NA no no no no up up Pathways in cancer cAMP signaling pathway 0.68 0.442687747 0.449163449 yes kegg kegg NA NA no no no no up up Pathways in cancer Carbohydrate digestion and absorption 0.486956522 0.673913043 0 kegg kegg NA NA no no no no no no Pathways in cancer Carbon metabolism -0.811304348 -0.587944664 -0.633462033 kegg kegg NA NA no no no no no no Pathways in cancer Cardiac muscle contraction 0.606956522 0 0 kegg kegg NA NA no no no no no up Pathways in cancer Cell adhesion molecules -0.570434783 0 -0.435778636 kegg kegg NA NA no no no no no no Pathways in cancer Cell cycle 0 0 0.410553411 kegg kegg NA NA no no no no no no Pathways in cancer cGMP-PKG signaling pathway 0.476521739 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Chagas disease 0 0.602766798 0 kegg kegg NA NA no no no no no no Pathways in cancer Chemokine signaling pathway 0 0.489130435 0 kegg kegg NA NA no no no no no no Pathways in cancer Cholinergic synapse 0.566086957 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Circadian rhythm 0.817391304 0 0.498584299 kegg kegg NA NA no no no no no no Pathways in cancer Citrate cycle (TCA cycle) -0.475652174 -0.666996047 0 kegg kegg NA NA no no no no no no Pathways in cancer Clostridium 0 -0.626565366 0 kegg Genus NA 0.925 no no no no no no Pathways in cancer Complement and coagulation cascades -0.453043478 0 -0.428828829 kegg kegg NA NA no no no no no no Pathways in cancer Coronavirus disease - COVID-19 0 -0.524703557 0 kegg kegg NA NA no no no no no no Pathways in cancer Cortisol synthesis and secretion 0 0 0.445559846 kegg kegg NA NA no no no no no up Pathways in cancer Cushing syndrome 0 0 0.658944659 kegg kegg NA NA no no no no no up Pathways in cancer Cysteine and methionine metabolism 0 -0.58201581 0 kegg kegg NA NA no no no no no no Pathways in cancer DNA replication 0 -0.433794466 0 kegg kegg NA NA no no no no no no Pathways in cancer Dopaminergic synapse 0.487826087 0 0 kegg kegg NA NA no no no no up no Pathways in cancer Drug metabolism - cytochrome P450 0 -0.662055336 -0.549034749 kegg kegg NA NA no no no no no no Pathways in cancer Drug metabolism - other enzymes -0.70173913 -0.720355731 0 kegg kegg NA NA no no no no no no Pathways in cancer Endocrine resistance 0 0 0.47027027 kegg kegg NA NA no no no no no no Pathways in cancer Endocytosis -0.431304348 0 0 kegg kegg NA NA no no no no no no Pathways in cancer ErbB signaling pathway 0.597391304 0.708498024 0.453796654 kegg kegg NA NA no no no no no no Pathways in cancer Estrogen signaling pathway 0 -0.475296443 0 kegg kegg NA NA no no no no no no Pathways in cancer Ether lipid metabolism 0.410434783 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Fat digestion and absorption 0 0 -0.441698842 yes kegg kegg NA NA no no no no up up Pathways in cancer Fatty acid biosynthesis 0 0.471343874 0 kegg kegg NA NA no no no no no no Pathways in cancer Fatty acid elongation -0.637391304 -0.555335968 0 kegg kegg NA NA no no no no no no Pathways in cancer Fatty acid metabolism -0.412173913 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Fc epsilon RI signaling pathway 0.445217391 0.469367589 0 kegg kegg NA NA no no no no no no Pathways in cancer Focal adhesion -0.437391304 -0.638339921 0 kegg kegg NA NA no no no no up up Pathways in cancer FoxO signaling pathway 0.488695652 0.711462451 0.566280566 kegg kegg NA NA no no no no no no Pathways in cancer Fructose and mannose metabolism -0.654782609 0 -0.433976834 kegg kegg NA NA no no no no no no Pathways in cancer GABAergic synapse 0 0.48715415 0 kegg kegg NA NA no no no no up up Pathways in cancer Galactose metabolism -0.593913043 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Gap junction 0 0.462450593 0 kegg kegg NA NA no no no no no no Pathways in cancer Gastric acid secretion 0 -0.548418972 0 kegg kegg NA NA no no no no no no Pathways in cancer Gemmiger 0 0.437191114 0 butyrate-producing kegg Genus NA 0.595 no no no no no no Pathways in cancer Glucagon signaling pathway 0 0 0.54028314 kegg kegg NA NA no no no no no no Pathways in cancer Glutamatergic synapse 0 0.53458498 0 kegg kegg NA NA no no no no up up Pathways in cancer Glutathione metabolism -0.524347826 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Glycerolipid metabolism 0 0.580039526 0 kegg kegg NA NA no no no no no up Pathways in cancer Glycerophospholipid metabolism 0.446956522 0.496047431 0 kegg kegg NA NA no no no no no up Pathways in cancer "Glycine, serine and threonine metabolism" -0.434782609 0 0 kegg kegg NA NA no no no no up no Pathways in cancer Glycolysis / Gluconeogenesis -0.713043478 -0.740118577 -0.50965251 kegg kegg NA NA no no no no no no Pathways in cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.677865613 0 kegg kegg NA NA no no no no no no Pathways in cancer Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.55826087 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.54743083 0 kegg kegg NA NA no no no no no no Pathways in cancer Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0 0.400514801 kegg kegg NA NA no no no no no no Pathways in cancer GnRH secretion 0.689565217 0.712450593 0 kegg kegg NA NA no no no no up up Pathways in cancer "Growth hormone synthesis, secretion and action" 0.506086957 0.668972332 0.545173745 kegg kegg NA NA no no no no no no Pathways in cancer Hedgehog signaling pathway 0.737391304 0 0.425740026 kegg kegg NA NA no no no no no no Pathways in cancer Hematopoietic cell lineage 0 -0.553359684 0 kegg kegg NA NA no no no no no no Pathways in cancer Hepatitis B 0.643478261 0.693675889 0.541570142 kegg kegg NA NA no no no no no no Pathways in cancer Hepatitis C 0.515652174 0 0.681338481 kegg kegg NA NA no no no no no no Pathways in cancer HIF-1 signaling pathway 0 -0.548418972 0 kegg kegg NA NA no no no no no no Pathways in cancer Hippo signaling pathway 0 -0.545454545 0 kegg kegg NA NA no no no no no no Pathways in cancer Hippo signaling pathway - multiple species 0 0.477272727 0 kegg kegg NA NA no no no no no no Pathways in cancer Histidine metabolism -0.432173913 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Human papillomavirus infection -0.413913043 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Huntington disease 0.605217391 -0.437747036 0 kegg kegg NA NA no no no no no no Pathways in cancer Inflammatory mediator regulation of TRP channels 0 0 0.413127413 kegg kegg NA NA no no no no no no Pathways in cancer Influenza A 0 0 -0.493951094 kegg kegg NA NA no no no no no no Pathways in cancer Inositol phosphate metabolism 0 0.469367589 0 kegg kegg NA NA no no no no no no Pathways in cancer Insulin resistance 0.679130435 0.765810277 0.539253539 kegg kegg NA NA no no no no no no Pathways in cancer Insulin secretion 0 0 0.410810811 yes kegg kegg NA NA no no no no up up Pathways in cancer Insulin signaling pathway 0 -0.483201581 0 kegg kegg NA NA no no no no no no Pathways in cancer JAK-STAT signaling pathway 0 0.769762846 0.525353925 kegg kegg NA NA no no no no no no Pathways in cancer Leishmaniasis -0.450434783 -0.565217391 0 kegg kegg NA NA no no no no no no Pathways in cancer Leukocyte transendothelial migration 0 -0.436758893 -0.458944659 kegg kegg NA NA no no no no no no Pathways in cancer Long-term potentiation 0.573913043 -0.533596838 0 kegg kegg NA NA no no no no no up Pathways in cancer Lysosome 0 0 -0.444530245 kegg kegg NA NA no no no no no no Pathways in cancer Mannose type O-glycan biosynthesis 0.496521739 0 0 kegg kegg NA NA no no no no no no Pathways in cancer MAPK signaling pathway 0.419130435 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Melanogenesis 0 0 0.402831403 kegg kegg NA NA no no no no no no Pathways in cancer Metabolism of xenobiotics by cytochrome P450 -0.486956522 -0.712450593 -0.576833977 kegg kegg NA NA no no no no no no Pathways in cancer mRNA surveillance pathway 0.74 0 0.455598456 kegg kegg NA NA no no no no no no Pathways in cancer mTOR signaling pathway 0 -0.433794466 0 kegg kegg NA NA no no no no no no Pathways in cancer Natural killer cell mediated cytotoxicity -0.556521739 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Neurotrophin signaling pathway 0.612173913 0.475296443 0 kegg kegg NA NA no no no no no no Pathways in cancer Neutrophil extracellular trap formation 0 0 -0.482625483 kegg kegg NA NA no no no no no no Pathways in cancer NF-kappa B signaling pathway 0 0.708498024 0.493693694 kegg kegg NA NA no no no no no no Pathways in cancer Nicotinate and nicotinamide metabolism 0 0.453557312 0 kegg kegg NA NA no no no no no no Pathways in cancer Nitrogen metabolism 0 0.437747036 0 kegg kegg NA NA no no no no no no Pathways in cancer Non-alcoholic fatty liver disease 0.671304348 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Non-homologous end-joining -0.557391304 -0.613636364 0 kegg kegg NA NA no no no no no no Pathways in cancer Notch signaling pathway 0.513913043 0.610671937 0 kegg kegg NA NA no no no no no no Pathways in cancer Oocyte meiosis 0 -0.616600791 0 kegg kegg NA NA no no no no no no Pathways in cancer Other types of O-glycan biosynthesis 0.539130435 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Oxidative phosphorylation 0.549565217 -0.437747036 0 kegg kegg NA NA no no no no no no Pathways in cancer Oxytocin signaling pathway -0.430434783 -0.445652174 -0.473359073 kegg kegg NA NA no no no no no no Pathways in cancer p53 signaling pathway 0.633043478 0.511857708 0.556756757 kegg kegg NA NA no no no no no no Pathways in cancer Parabacteroides -0.539130435 0 0 kegg Genus NA 4.19E-05 no no no no up up Pathways in cancer Parkinson disease 0 -0.418972332 0 kegg kegg NA NA no no no no no no Pathways in cancer Pathogenic Escherichia coli infection 0 0 -0.513256113 kegg kegg NA NA no no no no no no Pathways in cancer Pentose and glucuronate interconversions 0 -0.552371542 0 kegg kegg NA NA no no no no no no Pathways in cancer Pentose phosphate pathway -0.493913043 0 -0.402316602 kegg kegg NA NA no no no no no no Pathways in cancer Phagosome -0.610434783 0 -0.544144144 kegg kegg NA NA no no no no no no Pathways in cancer Phenylalanine metabolism -0.6 -0.532608696 0 kegg kegg NA NA no no no no no no Pathways in cancer Phosphatidylinositol signaling system 0.751304348 0 0.409009009 kegg kegg NA NA no no no no no no Pathways in cancer Phospholipase D signaling pathway 0 0.65513834 0 kegg kegg NA NA no no no no up up Pathways in cancer Phototransduction 0 -0.766798419 0 kegg kegg NA NA no no no no no no Pathways in cancer Platelet activation -0.446956522 -0.548418972 0 kegg kegg NA NA no no no no no no Pathways in cancer Platinum drug resistance 0.446086957 0.441699605 0.4996139 kegg kegg NA NA no no no no no no Pathways in cancer Porphyrin and chlorophyll metabolism -0.471304348 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Primary bile acid biosynthesis 0 -0.651185771 0 kegg kegg NA NA no no no no no no Pathways in cancer Prion disease 0.507826087 -0.517786561 0 kegg kegg NA NA no no no no no no Pathways in cancer Progesterone-mediated oocyte maturation 0.55826087 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Prolactin signaling pathway 0.495652174 0.548418972 0.406435006 kegg kegg NA NA no no no no no no Pathways in cancer Propanoate metabolism 0 -0.585968379 0 kegg kegg NA NA no no no no no no Pathways in cancer Proteasome 0 -0.802371542 0 kegg kegg NA NA no no no no no no Pathways in cancer Protein export 0.463478261 -0.602766798 0 kegg kegg NA NA no no no no no no Pathways in cancer Pyramidobacter 0 0 0.444287076 kegg Genus NA 0.45 no no no no no no Pathways in cancer Pyrimidine metabolism -0.54173913 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Pyruvate metabolism 0 -0.588932806 0 kegg kegg NA NA no no no no no no Pathways in cancer Regulation of actin cytoskeleton -0.48173913 -0.583003953 -0.404890605 kegg kegg NA NA no no no no no no Pathways in cancer Relaxin signaling pathway 0.48 0.601778656 0 kegg kegg NA NA no no no no no no Pathways in cancer Retinol metabolism -0.445217391 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Retrograde endocannabinoid signaling 0.47826087 -0.464426877 0 kegg kegg NA NA no no no no no up Pathways in cancer Ribosome 0 -0.523715415 0 kegg kegg NA NA no no no no no no Pathways in cancer RIG-I-like receptor signaling pathway 0.412173913 0.656126482 0.493178893 kegg kegg NA NA no no no no no no Pathways in cancer RNA degradation 0.645217391 0 0 kegg kegg NA NA no no no no no no Pathways in cancer RNA polymerase 0.415652174 0 0 kegg kegg NA NA no no no no no no Pathways in cancer RNA transport 0 -0.470355731 0 kegg kegg NA NA no no no no no no Pathways in cancer Ruminococcus 0 -0.553245877 0 kegg Genus NA 0.0679 no no no no no dn Pathways in cancer Salmonella infection 0 0 -0.415186615 kegg kegg NA NA no no no no no no Pathways in cancer Signaling pathways regulating pluripotency of stem cells 0.826956522 0.497035573 0.64041184 kegg kegg NA NA no no no no no no Pathways in cancer SNARE interactions in vesicular transport 0 0.492094862 0 kegg kegg NA NA no no no no no no Pathways in cancer Sphingolipid signaling pathway 0.639130435 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Spinocerebellar ataxia 0.633043478 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Spliceosome 0 0 0.522265122 kegg kegg NA NA no no no no no no Pathways in cancer Staphylococcus aureus infection -0.525217391 0 -0.528957529 kegg kegg NA NA no no no up no no Pathways in cancer Starch and sucrose metabolism 0 0 -0.433719434 kegg kegg NA NA no no no no no no Pathways in cancer Steroid biosynthesis 0 -0.530632411 0 kegg kegg NA NA no no no no no no Pathways in cancer Steroid hormone biosynthesis -0.563478261 -0.498023715 0 kegg kegg NA NA no no no no no no Pathways in cancer Sulfur metabolism -0.622608696 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Synaptic vesicle cycle 0 0 -0.487001287 kegg kegg NA NA no no no no up up Pathways in cancer T cell receptor signaling pathway 0.432173913 0.523715415 0.480566281 kegg kegg NA NA no no no no no no Pathways in cancer Taurine and hypotaurine metabolism 0.533043478 0.661067194 0 kegg kegg NA NA no no no no no no Pathways in cancer TGF-beta signaling pathway 0.446956522 -0.481225296 0 kegg kegg NA NA no no no no no no Pathways in cancer Thermogenesis 0.493913043 -0.473320158 0 kegg kegg NA NA no no no no no no Pathways in cancer Thiamine metabolism 0 -0.453557312 0 kegg kegg NA NA no no no no no no Pathways in cancer Tight junction -0.549565217 -0.688735178 -0.694465894 kegg kegg NA NA no no no no no no Pathways in cancer TNF signaling pathway 0.491304348 0.670948617 0 kegg kegg NA NA no no no no no no Pathways in cancer Toll-like receptor signaling pathway 0 0.484189723 0 yes kegg kegg NA NA no no no no no no Pathways in cancer Tryptophan metabolism -0.602608696 -0.641304348 0 kegg kegg NA NA no no no no up no Pathways in cancer Tuberculosis 0 0 -0.552638353 kegg kegg NA NA no no no no no dn Pathways in cancer Type I diabetes mellitus -0.551304348 0 -0.433719434 kegg kegg NA NA no no no no no no Pathways in cancer Type II diabetes mellitus 0.548695652 0.791501976 0 kegg kegg NA NA no no no no no no Pathways in cancer Tyrosine metabolism -0.527826087 -0.504940711 0 kegg kegg NA NA no no no no no no Pathways in cancer "Valine, leucine and isoleucine degradation" -0.453043478 -0.551383399 0 kegg kegg NA NA no no no no no no Pathways in cancer Vascular smooth muscle contraction 0 -0.447628458 0 kegg kegg NA NA no no no no no no Pathways in cancer VEGF signaling pathway 0.643478261 0.568181818 0 kegg kegg NA NA no no no no no no Pathways in cancer Vibrio cholerae infection 0 -0.522727273 0 kegg kegg NA NA no no no no no no Pathways in cancer Vitamin digestion and absorption 0.613043478 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Wnt signaling pathway 0.546086957 0 0 kegg kegg NA NA no no no no no no Pathways in cancer Yersinia infection 0 0 -0.435006435 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases 2-Oxocarboxylic acid metabolism -0.449565217 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases ABC transporters -0.503478261 0 0 kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases Adherens junction 0 0.529644269 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Adipocytokine signaling pathway 0.470434783 0 0.423680824 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Adrenergic signaling in cardiomyocytes 0.769565217 0.824110672 0 kegg kegg NA NA no no no no no up Pathways of neurodegeneration - multiple diseases AGE-RAGE signaling pathway in diabetic complications 0 -0.76284585 -0.574517375 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases "Alanine, aspartate and glutamate metabolism" -0.587826087 -0.646245059 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Aldosterone synthesis and secretion 0.72 0.787549407 0 kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases Aldosterone-regulated sodium reabsorption 0 0 -0.742084942 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases alpha-Linolenic acid metabolism -0.643478261 -0.708498024 -0.439124839 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Alzheimer disease 0.826086957 0.960474308 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Amino sugar and nucleotide sugar metabolism -0.582608696 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Aminoacyl-tRNA biosynthesis -0.595652174 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases AMPK signaling pathway 0 0.542490119 0.511196911 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Amyotrophic lateral sclerosis 0.88173913 0.935770751 0.465379665 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Apelin signaling pathway 0.436521739 0.722332016 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Apoptosis -0.473913043 -0.572134387 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Arachidonic acid metabolism 0 0 0.404118404 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Arginine and proline metabolism -0.480869565 -0.71541502 0 kegg kegg NA NA no no no no up no Pathways of neurodegeneration - multiple diseases Arginine biosynthesis -0.613913043 -0.593873518 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Autophagy - animal 0 -0.606719368 -0.577863578 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Axon guidance 0.430434783 0 0 kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases B cell receptor signaling pathway 0 -0.587944664 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases beta-Alanine metabolism -0.69826087 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Bile secretion 0.605217391 0.528656126 0.536936937 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Biosynthesis of amino acids -0.751304348 -0.615612648 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Biosynthesis of cofactors 0 0.451581028 0.408751609 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Biosynthesis of unsaturated fatty acids -0.58 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Butanoate metabolism -0.500869565 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases C-type lectin receptor signaling pathway 0 -0.549407115 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Calcium signaling pathway 0.71826087 0.714426877 0 kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases cAMP signaling pathway 0.73826087 0 0 yes kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases Carbohydrate digestion and absorption 0 -0.46541502 -0.645817246 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Carbon metabolism -0.663478261 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Cardiac muscle contraction 0.787826087 0.910079051 0 kegg kegg NA NA no no no no no up Pathways of neurodegeneration - multiple diseases Cell adhesion molecules -0.485217391 -0.496047431 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Cellular senescence 0 -0.450592885 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases cGMP-PKG signaling pathway 0 -0.64229249 -0.436550837 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Chemokine signaling pathway 0 -0.448616601 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Cholinergic synapse 0 -0.449604743 -0.46975547 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Circadian entrainment 0.439130435 0.503952569 0.514285714 kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases Circadian rhythm 0.59826087 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Complement and coagulation cascades -0.58173913 -0.656126482 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Cortisol synthesis and secretion 0.62173913 0.493083004 0.442213642 kegg kegg NA NA no no no no no up Pathways of neurodegeneration - multiple diseases Cushing syndrome 0.613913043 0.530632411 0 kegg kegg NA NA no no no no no up Pathways of neurodegeneration - multiple diseases Cytokine-cytokine receptor interaction 0 -0.484189723 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Dopaminergic synapse 0.733913043 0.670948617 0 kegg kegg NA NA no no no no up no Pathways of neurodegeneration - multiple diseases Drug metabolism - cytochrome P450 0 0.433794466 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Drug metabolism - other enzymes -0.522608696 0.46541502 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases EGFR tyrosine kinase inhibitor resistance 0 0.659090909 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Endocrine and other factor-regulated calcium reabsorption 0.649565217 0.802371542 0.541570142 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Endocrine resistance 0.49826087 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Endocytosis -0.426086957 -0.516798419 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases ErbB signaling pathway 0 -0.448616601 -0.576833977 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Ether lipid metabolism 0.775652174 0.457509881 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Fat digestion and absorption -0.614782609 -0.593873518 -0.45019305 yes kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases Fatty acid biosynthesis -0.613913043 -0.736166008 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Fatty acid degradation -0.850434783 -0.781620553 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Fatty acid elongation -0.585217391 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Fatty acid metabolism -0.914782609 -0.780632411 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Fc epsilon RI signaling pathway 0 -0.679841897 -0.573745174 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Fc gamma R-mediated phagocytosis -0.740869565 -0.662055336 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Ferroptosis 0.452173913 0 0.627541828 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases FoxO signaling pathway -0.415652174 -0.722332016 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Fructose and mannose metabolism -0.626956522 -0.495059289 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases GABAergic synapse -0.473913043 -0.559288538 0 kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases Galactose metabolism -0.757391304 -0.787549407 -0.416731017 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Gastric acid secretion 0 0.62944664 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Glucagon signaling pathway 0.525217391 0.778656126 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Glutathione metabolism 0 0.713438735 0.574774775 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Glycerolipid metabolism 0 -0.604743083 0 kegg kegg NA NA no no no no no up Pathways of neurodegeneration - multiple diseases "Glycine, serine and threonine metabolism" 0 0.492094862 0 kegg kegg NA NA no no no no up no Pathways of neurodegeneration - multiple diseases Glycolysis / Gluconeogenesis -0.603478261 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.678853755 -0.406692407 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Glycosaminoglycan biosynthesis - keratan sulfate 0.600869565 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Glycosaminoglycan degradation 0 -0.482213439 -0.502445302 kegg kegg NA NA no no no no no up Pathways of neurodegeneration - multiple diseases Glycosphingolipid biosynthesis - lacto and neolacto series 0.426086957 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Glyoxylate and dicarboxylate metabolism -0.717391304 -0.602766798 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases GnRH secretion 0 0 -0.416216216 kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases GnRH signaling pathway 0.599130435 0.553359684 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Hematopoietic cell lineage -0.409565217 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases HIF-1 signaling pathway 0 0.617588933 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Hippo signaling pathway 0 0.513833992 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Hippo signaling pathway - multiple species 0 -0.699604743 -0.592277992 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Histidine metabolism -0.507826087 0 -0.431660232 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Huntington disease 0.844347826 0.960474308 0.515315315 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases IL-17 signaling pathway 0 -0.520750988 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Inflammatory mediator regulation of TRP channels 0.631304348 0.756916996 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Inositol phosphate metabolism -0.424347826 -0.451581028 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Insulin resistance 0 -0.459486166 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Insulin secretion 0.579130435 0.599802372 0 yes kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases Insulin signaling pathway 0 0.668972332 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases JAK-STAT signaling pathway -0.466086957 -0.657114625 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Long-term depression 0.666086957 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Longevity regulating pathway 0.454782609 0 0.508108108 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Lysosome 0 -0.43083004 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Mannose type O-glycan biosynthesis 0.539130435 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases MAPK signaling pathway 0 -0.660079051 -0.564993565 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Melanogenesis 0.600869565 0.822134387 0.44967825 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Mineral absorption 0.72 0.661067194 0.758815959 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Mitophagy - animal 0.883478261 0.924901186 0.829086229 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases mRNA surveillance pathway 0.714782609 0.630434783 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases mTOR signaling pathway 0.417391304 0.66798419 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Mucin type O-glycan biosynthesis 0 -0.443675889 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases N-Glycan biosynthesis 0 0.462450593 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Natural killer cell mediated cytotoxicity 0 -0.457509881 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Necroptosis 0.58 0.437747036 0.671557272 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Neuroactive ligand-receptor interaction 0 -0.572134387 0 kegg kegg NA NA no no no up up up Pathways of neurodegeneration - multiple diseases Neurotrophin signaling pathway 0.468695652 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Neutrophil extracellular trap formation -0.593043478 -0.561264822 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases NF-kappa B signaling pathway -0.427826087 -0.618577075 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Nicotinate and nicotinamide metabolism -0.590434783 -0.681818182 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Nitrogen metabolism -0.425217391 -0.488142292 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases NOD-like receptor signaling pathway -0.630434783 -0.666007905 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Non-alcoholic fatty liver disease 0.852173913 0.942687747 0.593050193 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Non-homologous end-joining -0.655652174 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Olfactory transduction -0.415652174 -0.588932806 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Oscillospira 0 -0.457509881 0 LPS-producing kegg Genus NA 0.62 no no no no no no Pathways of neurodegeneration - multiple diseases Osteoclast differentiation -0.48173913 -0.707509881 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Other glycan degradation 0 -0.499011858 -0.507335907 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Ovarian steroidogenesis 0.423478261 0.421936759 0.451222651 kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases Oxidative phosphorylation 0.809565217 0.945652174 0.420592021 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Pancreatic secretion 0.766956522 0.688735178 0.431917632 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Pantothenate and CoA biosynthesis -0.595652174 -0.751976285 0 kegg kegg NA NA no no no no no dn Pathways of neurodegeneration - multiple diseases "Parathyroid hormone synthesis, secretion and action" 0.847826087 0.846837945 0.59047619 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Parkinson disease 0.997391304 0.995059289 0.989446589 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Pentose and glucuronate interconversions 0 0.438735178 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Pentose phosphate pathway -0.446086957 -0.614624506 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Peroxisome -0.750434783 -0.656126482 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Phagosome -0.517391304 -0.515810277 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Phosphatidylinositol signaling system 0.432173913 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Phospholipase D signaling pathway 0 -0.47826087 0 kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases Phototransduction 0 0.459486166 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Platelet activation 0 0.429841897 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Porphyrin and chlorophyll metabolism 0 0.526679842 0.477220077 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases PPAR signaling pathway 0 -0.546442688 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Primary bile acid biosynthesis -0.46173913 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Prion disease 0.75826087 0.916007905 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Prolactin signaling pathway 0 -0.627470356 -0.441441441 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Proteasome 0 0.435770751 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Protein digestion and absorption -0.77826087 -0.846837945 -0.638610039 yes kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases Protein export 0.531304348 0.705533597 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Protein processing in endoplasmic reticulum 0.433913043 0.59486166 0.607979408 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Purine metabolism 0 0.535573123 0.553153153 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Pyrimidine metabolism -0.687826087 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Pyruvate metabolism 0 0.52173913 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Regulation of lipolysis in adipocytes 0.503478261 0 0.415186615 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Relaxin signaling pathway 0.682608696 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Renin secretion 0.479130435 0.780632411 0.538223938 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Renin-angiotensin system 0 -0.647233202 -0.422136422 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Retinol metabolism -0.613913043 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Retrograde endocannabinoid signaling 0.554782609 0.867588933 0 kegg kegg NA NA no no no no no up Pathways of neurodegeneration - multiple diseases Ribosome 0.827826087 0.858695652 0.574002574 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases RIG-I-like receptor signaling pathway 0 -0.565217391 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases RNA degradation 0.675652174 0.590909091 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases RNA polymerase 0 0.533596838 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases RNA transport 0 0.542490119 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Ruminococcus 0.410434783 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Pathways of neurodegeneration - multiple diseases Signaling pathways regulating pluripotency of stem cells 0.42173913 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases SNARE interactions in vesicular transport 0 -0.64229249 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Sphingolipid metabolism 0 0 -0.505276705 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Sphingolipid signaling pathway 0 0 -0.576833977 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Starch and sucrose metabolism -0.591304348 -0.767786561 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Synaptic vesicle cycle 0 -0.563241107 0 kegg kegg NA NA no no no no up up Pathways of neurodegeneration - multiple diseases T cell receptor signaling pathway 0 -0.454545455 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases TGF-beta signaling pathway 0.646086957 0.578063241 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Th1 and Th2 cell differentiation 0 -0.45256917 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Th17 cell differentiation 0 -0.437747036 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Thermogenesis 0.86 0.93083004 0.499099099 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Thiamine metabolism 0 0.428853755 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Thyroid hormone signaling pathway 0 0.522727273 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Thyroid hormone synthesis 0.553043478 0.664031621 0.598970399 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Tight junction 0 0.438735178 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases TNF signaling pathway 0 -0.485177866 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Toll-like receptor signaling pathway 0 -0.57312253 0 yes kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Tryptophan metabolism -0.56 0 0 kegg kegg NA NA no no no no up no Pathways of neurodegeneration - multiple diseases Type I diabetes mellitus 0 -0.415019763 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Type II diabetes mellitus 0 -0.568181818 -0.649420849 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Ubiquinone and other terpenoid-quinone biosynthesis -0.412173913 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Ubiquitin mediated proteolysis 0.888695652 0.934782609 0.840926641 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases "Valine, leucine and isoleucine degradation" -0.451304348 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Vascular smooth muscle contraction 0.891304348 0.82312253 0.491891892 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Vasopressin-regulated water reabsorption 0.674782609 0.746047431 0.593050193 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases VEGF signaling pathway 0 -0.461462451 -0.501415701 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Vitamin digestion and absorption 0.46173913 0 0 kegg kegg NA NA no no no no no no Pathways of neurodegeneration - multiple diseases Wnt signaling pathway 0.664347826 0.550395257 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer 2-Oxocarboxylic acid metabolism -0.594782609 -0.520750988 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Acute myeloid leukemia 0.580869565 0.631422925 0.45971686 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Adherens junction -0.479130435 -0.742094862 -0.470527671 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Adipocytokine signaling pathway 0 0.7756917 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Adrenergic signaling in cardiomyocytes 0 -0.421936759 0 kegg kegg NA NA no no no no no up PD-L1 expression and PD-1 checkpoint pathway in cancer African trypanosomiasis 0.46173913 0.433794466 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer AGE-RAGE signaling pathway in diabetic complications 0 0.654150198 0.466409266 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer "Alanine, aspartate and glutamate metabolism" 0 0.686758893 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Aldosterone synthesis and secretion 0 -0.445652174 0 kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer Aldosterone-regulated sodium reabsorption 0.686086957 0.453557312 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Alzheimer disease 0 -0.548418972 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Amino sugar and nucleotide sugar metabolism -0.427826087 0 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Amoebiasis 0 0.514822134 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Amphetamine addiction 0 -0.62944664 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Amyotrophic lateral sclerosis 0 -0.583003953 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Apelin signaling pathway 0 -0.592885375 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Apoptosis 0 0.688735178 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Arachidonic acid metabolism -0.597391304 0 -0.668468468 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Arginine and proline metabolism 0 0.627470356 0 kegg kegg NA NA no no no no up no PD-L1 expression and PD-1 checkpoint pathway in cancer Arginine biosynthesis 0 0.658102767 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Ascorbate and aldarate metabolism -0.44173913 -0.509881423 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Autophagy - animal 0.747826087 0.894268775 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Autophagy - other 0.693913043 0.627470356 0.662805663 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Axon guidance 0.509565217 0 0 kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer B cell receptor signaling pathway 0.492173913 0.829051383 0.521492921 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Bacterial invasion of epithelial cells -0.504347826 -0.664031621 -0.551608752 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Basal cell carcinoma 0 0 0.652252252 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer beta-Alanine metabolism -0.684347826 -0.583003953 -0.542857143 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Bile secretion 0 -0.427865613 -0.401029601 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Biosynthesis of amino acids 0 0.433794466 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Biosynthesis of cofactors -0.571304348 -0.480237154 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Biosynthesis of unsaturated fatty acids -0.58173913 -0.505928854 -0.535392535 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Bladder cancer 0 0.701581028 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Breast cancer 0.813043478 0.761857708 0.650965251 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Butanoate metabolism -0.600869565 -0.704545455 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Butyricimonas 0.407820703 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer C-type lectin receptor signaling pathway 0.844347826 0.886363636 0.701930502 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer cAMP signaling pathway 0.615652174 0.609683794 0 yes kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer Carbohydrate digestion and absorption 0.816521739 0.603754941 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Carbon metabolism -0.566086957 0 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Cardiac muscle contraction 0 -0.513833992 0 kegg kegg NA NA no no no no no up PD-L1 expression and PD-1 checkpoint pathway in cancer Cell cycle 0 -0.448616601 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Cellular senescence 0 0.494071146 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer cGMP-PKG signaling pathway 0.439130435 0.462450593 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Chagas disease 0.764347826 0.848814229 0.435778636 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Chemokine signaling pathway 0.487826087 0.479249012 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Choline metabolism in cancer 0.786086957 0.681818182 0.512998713 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Cholinergic synapse 0.653043478 0 0.436293436 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Chronic myeloid leukemia 0.793913043 0.874505929 0.711969112 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Circadian entrainment 0 -0.783596838 -0.481853282 kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer Circadian rhythm 0.648695652 0 0.547490347 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Citrate cycle (TCA cycle) -0.591304348 -0.708498024 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Collecting duct acid secretion 0 0 -0.526640927 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Collinsella 0 0 -0.596145022 kegg Genus NA 0.128 no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Colorectal cancer 0.584347826 0 0.569369369 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Coronavirus disease - COVID-19 0 -0.507905138 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Cysteine and methionine metabolism 0 -0.685770751 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Cytokine-cytokine receptor interaction 0 0 -0.477477477 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Cytosolic DNA-sensing pathway 0 0.73715415 0.475160875 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer DNA replication 0 -0.693675889 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Dopaminergic synapse 0 -0.666996047 0 kegg kegg NA NA no no no no up no PD-L1 expression and PD-1 checkpoint pathway in cancer Drug metabolism - cytochrome P450 0 -0.833992095 -0.412097812 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Drug metabolism - other enzymes -0.62 -0.795454545 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer ECM-receptor interaction -0.408695652 -0.444664032 0 kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer Endocrine and other factor-regulated calcium reabsorption 0 -0.538537549 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Endometrial cancer 0.714782609 0.7756917 0.724581725 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Epithelial cell signaling in Helicobacter pylori infection 0.477391304 0.736166008 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer ErbB signaling pathway 0.64 0.613636364 0.583268983 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Estrogen signaling pathway 0 -0.743083004 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Fatty acid biosynthesis 0 0.646245059 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Fatty acid degradation 0 0.444664032 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Fatty acid elongation -0.7 -0.54743083 -0.497554698 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Fc epsilon RI signaling pathway 0.474782609 0.741106719 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Focal adhesion -0.532173913 -0.786561265 -0.432432432 kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer FoxO signaling pathway 0 0.565217391 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Fructose and mannose metabolism 0 0.428853755 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer GABAergic synapse 0 0.414031621 0 kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer Galactose metabolism -0.434782609 0.425889328 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Gap junction 0 0 -0.416731017 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Gastric acid secretion -0.553043478 -0.816205534 -0.564736165 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Gastric cancer 0.406956522 0 0.563449163 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Glioma 0.41826087 0 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Glucagon signaling pathway 0 -0.59486166 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Glutathione metabolism -0.475652174 -0.625494071 -0.623680824 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Glycerolipid metabolism 0 0.446640316 0.424195624 kegg kegg NA NA no no no no no up PD-L1 expression and PD-1 checkpoint pathway in cancer "Glycine, serine and threonine metabolism" -0.48 0 0 kegg kegg NA NA no no no no up no PD-L1 expression and PD-1 checkpoint pathway in cancer Glycolysis / Gluconeogenesis -0.548695652 -0.599802372 -0.48957529 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.763833992 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.553043478 0 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.464426877 0.456885457 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Glyoxylate and dicarboxylate metabolism 0 0.665019763 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer GnRH secretion 0.669565217 0.654150198 0.519176319 kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer "Growth hormone synthesis, secretion and action" 0.417391304 0 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Hedgehog signaling pathway 0 0 0.483397683 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Hematopoietic cell lineage -0.52173913 -0.473320158 -0.5001287 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Hepatitis B 0.847826087 0.895256917 0.802316602 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Hepatitis C 0.746956522 0.817193676 0.726383526 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Hepatocellular carcinoma -0.405217391 -0.678853755 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer HIF-1 signaling pathway 0 -0.457509881 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Hippo signaling pathway -0.602608696 -0.764822134 -0.401544402 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Hippo signaling pathway - multiple species 0 0.502964427 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Histidine metabolism -0.443478261 0 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Human papillomavirus infection 0 0.532608696 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Huntington disease 0 -0.548418972 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer IL-17 signaling pathway 0.453043478 0.472332016 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory mediator regulation of TRP channels 0 -0.660079051 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Insulin resistance 0.846956522 0.901185771 0.817503218 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Insulin signaling pathway 0 -0.529644269 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer JAK-STAT signaling pathway 0 0.735177866 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Lachnospira 0 -0.471954549 0 butyrate-producing kegg Genus NA 0.279 no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Linoleic acid metabolism 0 -0.419960474 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Long-term potentiation 0 -0.486166008 0.406177606 kegg kegg NA NA no no no no no up PD-L1 expression and PD-1 checkpoint pathway in cancer Lysine degradation 0 0 0.424710425 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Malaria 0 0.456521739 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Mannose type O-glycan biosynthesis 0.409565217 0 0.435778636 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer MAPK signaling pathway 0 0 0.528700129 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Measles 0.680869565 0 0.428314028 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Melanogenesis 0 -0.608695652 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Melanoma 0.830434783 0.825098814 0.686486486 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Metabolism of xenobiotics by cytochrome P450 -0.442608696 -0.834980237 -0.447619048 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer MicroRNAs in cancer 0 0.859683794 0.620592021 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Mismatch repair -0.465217391 -0.68083004 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Morphine addiction 0 -0.488142292 0 kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer mRNA surveillance pathway 0.467826087 0 0.418018018 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer N-Glycan biosynthesis 0 -0.625494071 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Neurotrophin signaling pathway 0.8 0.850790514 0.721235521 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer NF-kappa B signaling pathway 0.528695652 0.895256917 0.728700129 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Nicotinate and nicotinamide metabolism 0 0.601778656 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Nicotine addiction 0 0 0.412870013 kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer Nitrogen metabolism 0 0.626482213 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer NOD-like receptor signaling pathway 0 0.825098814 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Non-alcoholic fatty liver disease 0.406956522 -0.436758893 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Non-homologous end-joining -0.626956522 -0.605731225 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Non-small cell lung cancer 0.764347826 0.635375494 0.583783784 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Notch signaling pathway 0 0.434782609 0.43037323 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Nucleotide excision repair 0 -0.651185771 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer One carbon pool by folate 0 -0.71541502 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Oocyte meiosis 0 -0.637351779 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Osteoclast differentiation 0 0.701581028 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Other glycan degradation 0 0.45256917 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Oxidative phosphorylation 0 -0.54743083 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Oxytocin signaling pathway -0.537391304 -0.552371542 -0.673873874 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Pancreatic cancer 0.413913043 0 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Pancreatic secretion 0 -0.59486166 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Pantothenate and CoA biosynthesis 0 0.446640316 0 kegg kegg NA NA no no no no no dn PD-L1 expression and PD-1 checkpoint pathway in cancer Parkinson disease 0 -0.475296443 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Pathways in cancer 0.592173913 0.630434783 0.512483912 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Pathways of neurodegeneration - multiple diseases 0 -0.456521739 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Pentose and glucuronate interconversions -0.591304348 -0.668972332 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Peroxisome 0 0.511857708 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Pertussis 0 0.424901186 0 kegg kegg NA NA no no no no no dn PD-L1 expression and PD-1 checkpoint pathway in cancer Phenylalanine metabolism -0.705217391 -0.743083004 -0.423680824 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Phospholipase D signaling pathway 0 0.626482213 0 kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer Phototransduction 0 -0.68083004 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Platelet activation -0.54 -0.727272727 -0.482368082 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer PPAR signaling pathway 0 0.79743083 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Primary bile acid biosynthesis -0.594782609 -0.552371542 -0.572458172 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Prion disease 0 -0.595849802 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Progesterone-mediated oocyte maturation 0.515652174 0 0.513513514 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Prolactin signaling pathway 0.688695652 0.726284585 0.587902188 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Propanoate metabolism 0 -0.651185771 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Prostate cancer 0.828695652 0.895256917 0.81981982 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Proteasome 0 -0.596837945 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Protein digestion and absorption 0 0.462450593 0 yes kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer Protein export 0 -0.612648221 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Protein processing in endoplasmic reticulum 0 -0.542490119 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Proteoglycans in cancer 0 -0.490118577 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Proximal tubule bicarbonate reclamation 0 -0.769762846 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Pyrimidine metabolism -0.507826087 -0.732213439 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Pyruvate metabolism 0 -0.694664032 -0.401029601 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Rap1 signaling pathway 0 -0.527667984 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Ras signaling pathway 0 -0.663043478 0 yes kegg kegg NA NA no no no no up up PD-L1 expression and PD-1 checkpoint pathway in cancer Regulation of actin cytoskeleton -0.435652174 -0.677865613 -0.528442728 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Relaxin signaling pathway 0.697391304 0.662055336 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Renal cell carcinoma 0.543478261 0 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Renin secretion -0.443478261 -0.776679842 -0.423166023 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Retinol metabolism -0.456521739 -0.613636364 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Retrograde endocannabinoid signaling 0 -0.653162055 0 kegg kegg NA NA no no no no no up PD-L1 expression and PD-1 checkpoint pathway in cancer Ribosome 0 -0.520750988 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer RIG-I-like receptor signaling pathway 0.833913043 0.910079051 0.694980695 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer RNA degradation 0 -0.495059289 0.452767053 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer RNA polymerase 0 -0.48715415 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Salivary secretion -0.42173913 -0.599802372 -0.43989704 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Signaling pathways regulating pluripotency of stem cells 0.650434783 0 0.548262548 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Small cell lung cancer 0.570434783 0.889328063 0.594079794 kegg kegg NA NA no no no no no up PD-L1 expression and PD-1 checkpoint pathway in cancer SNARE interactions in vesicular transport 0 0.626482213 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Sphingolipid signaling pathway 0.617391304 0.510869565 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Spinocerebellar ataxia 0.666956522 0 0.462033462 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Spliceosome 0 0 0.416216216 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Staphylococcus aureus infection -0.431304348 0 0 kegg kegg NA NA no no no up no no PD-L1 expression and PD-1 checkpoint pathway in cancer Starch and sucrose metabolism 0 0.517786561 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Steroid biosynthesis 0 -0.704545455 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Steroid hormone biosynthesis -0.605217391 -0.736166008 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Sulfur metabolism -0.644347826 -0.441699605 -0.445302445 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Synthesis and degradation of ketone bodies 0 -0.572134387 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer T cell receptor signaling pathway 0.684347826 0.794466403 0.663063063 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Taste transduction 0 -0.532608696 0 kegg kegg NA NA no no no no no up PD-L1 expression and PD-1 checkpoint pathway in cancer Taurine and hypotaurine metabolism 0 0.551383399 0.452767053 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer TGF-beta signaling pathway 0 -0.60770751 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Th1 and Th2 cell differentiation 0 0.453557312 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Th17 cell differentiation 0 0.563241107 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Thermogenesis 0 -0.593873518 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Thiamine metabolism 0 -0.488142292 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Thyroid hormone signaling pathway 0 -0.644268775 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Thyroid hormone synthesis 0 0 -0.423680824 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Tight junction -0.56 -0.708498024 -0.703474903 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer TNF signaling pathway 0.910434783 0.92687747 0.694465894 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Toll-like receptor signaling pathway 0.769565217 0.841897233 0.505019305 yes kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Transcriptional misregulation in cancer 0.703478261 0.837944664 0.716859717 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Tryptophan metabolism -0.653043478 -0.674901186 0 kegg kegg NA NA no no no no up no PD-L1 expression and PD-1 checkpoint pathway in cancer Type II diabetes mellitus 0.837391304 0.711462451 0.500900901 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Tyrosine metabolism -0.713913043 -0.833992095 -0.56962677 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Ubiquinone and other terpenoid-quinone biosynthesis -0.594782609 -0.640316206 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer "Valine, leucine and isoleucine degradation" -0.571304348 -0.701581028 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Various types of N-glycan biosynthesis 0 -0.446640316 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Vascular smooth muscle contraction 0 -0.664031621 -0.401544402 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Vasopressin-regulated water reabsorption 0 -0.644268775 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer VEGF signaling pathway 0.653913043 0.550395257 0.523809524 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Vibrio cholerae infection -0.486086957 -0.736166008 -0.519176319 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Viral carcinogenesis 0 0.577075099 0 kegg kegg NA NA no no no no no no PD-L1 expression and PD-1 checkpoint pathway in cancer Wnt signaling pathway 0 -0.552371542 0.462033462 kegg kegg NA NA no no no no no no PDGF-bb 16:0-LPC+blood 0 0 0.463157895 yes serum_cytokines serum_phospholipids 0.111 0.00456 no no no up up no PDGF-bb 16:0/16:1-PC+blood 0.648484848 0 0 yes serum_cytokines serum_phospholipids 0.111 0.00283 no no no up up no PDGF-bb 16:0/18:0-PC+blood 0 -0.660714286 0 yes serum_cytokines serum_phospholipids 0.111 0.521 no no no no no no PDGF-bb 16:0/22:6-PC+blood -0.76969697 0 0 yes serum_cytokines serum_phospholipids 0.111 4.53E-05 no no no no up up PDGF-bb 16:1/16:1-PC+blood 0 -0.528571429 0 yes serum_cytokines serum_phospholipids 0.111 0.0177 no no no no no up PDGF-bb 16:1+blood 0 0 -0.446616541 yes yes serum_cytokines serum_fattyacid 0.111 0.0186 no no no no no dn PDGF-bb 18:0-LPC+blood 0 0 0.615037594 yes serum_cytokines serum_phospholipids 0.111 0.554 no no no no no no PDGF-bb 18:0-LPE+blood 0 0 0.490225564 yes serum_cytokines serum_phospholipids 0.111 0.491 no no no no no no PDGF-bb 18:0/18:0-PC+blood 0 -0.617857143 0 yes serum_cytokines serum_phospholipids 0.111 0.426 no no no no no no PDGF-bb 18:0/18:1-PC+blood 0 -0.596428571 0 yes serum_cytokines serum_phospholipids 0.111 0.393 no no no no no no PDGF-bb 18:0/20:5-PC+blood -0.83030303 0 0 yes serum_cytokines serum_phospholipids 0.111 0.17 no no no no no no PDGF-bb 18:0/22:6-PA+blood 0 -0.610714286 0 yes serum_cytokines serum_phospholipids 0.111 0.22 no no no no no no PDGF-bb 18:0/22:6-PC+blood -0.672727273 0 0 yes serum_cytokines serum_phospholipids 0.111 0.0775 no no no no no up PDGF-bb 18:1+blood -0.636363636 0 -0.45112782 yes yes serum_cytokines serum_fattyacid 0.111 0.00202 no no no up no dn PDGF-bb 18:2-LPA+blood 0.781818182 0 0 yes serum_cytokines serum_phospholipids 0.111 0.00684 no no no dn no up PDGF-bb 18:3n3+blood -0.733333333 0 0 yes serum_cytokines serum_fattyacid 0.111 0.291 no no no no no no PDGF-bb 20:3/18:0-PC+blood 0 -0.528571429 0 yes serum_cytokines serum_phospholipids 0.111 0.296 no no no no no no PDGF-bb 20:5/18:0-PC+blood -0.648484848 0 0 yes serum_cytokines serum_phospholipids 0.111 3.97E-06 no no no no up up PDGF-bb "9,10-EPOME+blood" 0.675329831 0 0 yes serum_cytokines serum_ARA 0.111 0.801 no no no no no no PDGF-bb Adipocytokine signaling pathway 0 0.457142857 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb Amoebiasis -0.571428571 0.47518797 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb Butyric acid+stool 0 0 0.522058824 yes yes serum_cytokines stool_scfa 0.111 0.102 no no no dn no no PDGF-bb C-type lectin receptor signaling pathway 0 0.503759398 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb Calcium signaling pathway 0 0 0.45210728 yes serum_cytokines kegg 0.111 NA no no no no up up PDGF-bb cAMP signaling pathway 0 0.587969925 0 yes yes serum_cytokines kegg 0.111 NA no no no no up up PDGF-bb cGMP-PKG signaling pathway -0.642857143 0 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb Chagas disease 0 0.571428571 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb Chronic myeloid leukemia 0 0.467669173 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb Cocaine addiction 0 0 0.400656814 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb Cysteine+blood 0 0 -0.472180451 yes yes serum_cytokines serum_aminoacids 0.111 1.81E-07 no no no dn up up PDGF-bb Cytosolic DNA-sensing pathway 0 0.554887218 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb d18:1-14:0-SM+blood 0 -0.575 0 yes serum_cytokines serum_phospholipids 0.111 0.94 no no no no no no PDGF-bb d18:1-20:0-SM+blood 0 0 0.580451128 yes serum_cytokines serum_phospholipids 0.111 0.933 no no no no no no PDGF-bb d18:1-22:1-SM+blood 0 0 0.476691729 yes serum_cytokines serum_phospholipids 0.111 0.222 no no no no no no PDGF-bb Dorea 0 0 0.456061551 yes serum_cytokines Genus 0.111 0.00362 no no no up no dn PDGF-bb DPA+blood 0 0.535714286 0 yes serum_cytokines serum_ARA 0.111 0.519 no no no no no no PDGF-bb Ethanolamine+blood 0 0.539285714 0 yes serum_cytokines serum_aminoacids 0.111 0.122 no no no up no no PDGF-bb Faecalibacterium 0 0.484415584 0 yes butyrate-producing serum_cytokines Genus 0.111 0.0039 no no no no dn dn PDGF-bb FoxO signaling pathway -0.82967033 0 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb GABAergic synapse -0.71978022 0 0 yes serum_cytokines kegg 0.111 NA no no no no up up PDGF-bb Glioma -0.626373626 0 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb Glutamatergic synapse -0.637362637 0 0 yes serum_cytokines kegg 0.111 NA no no no no up up PDGF-bb Glycolysis / Gluconeogenesis 0 -0.527819549 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb "Growth hormone synthesis, secretion and action" 0 0.472180451 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb HCA+stool -0.709090909 0 0 yes serum_cytokines stool_bileacids 0.111 0.155 no no no no no no PDGF-bb Hematopoietic cell lineage 0 -0.47518797 -0.407224959 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb IL-13 0 -0.592207792 -0.687208009 yes yes serum_cytokines serum_cytokines 0.111 0.00264 no no no up up no PDGF-bb IL-1b 0 -0.533766234 -0.53592881 yes yes serum_cytokines serum_cytokines 0.111 0.00358 no no no up up no PDGF-bb IL-8 -0.708791209 0 0 yes serum_cytokines serum_cytokines 0.111 0.579 no no no no no no PDGF-bb iso-LCA+stool 0.802435318 0 0 yes serum_cytokines stool_bileacids 0.111 0.72 no no no no no no PDGF-bb L-Alanine+blood 0 0 0.491729323 yes yes serum_cytokines serum_aminoacids 0.111 0.00138 no no no up up no PDGF-bb L-Ornithine+blood 0 0.553571429 0 yes serum_cytokines serum_aminoacids 0.111 0.175 no no no no no no PDGF-bb L-Tryptophan+urine 0 0 0.457894737 yes serum_cytokines urine_cometabolism 0.111 0.226 no no no no no no PDGF-bb LCA+blood 0.665903429 0 0 yes serum_cytokines serum_bileacids 0.111 0.884 no no no no no no PDGF-bb LCA+stool 0.793939394 0 0 yes serum_cytokines stool_bileacids 0.111 0.314 no no no no no no PDGF-bb Long-term depression 0 0.470676692 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb MUFA+blood -0.636363636 0 -0.47518797 yes serum_cytokines serum_fattyacid 0.111 0.00175 no no no up no dn PDGF-bb Neurotrophin signaling pathway 0 0.472180451 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb nutriCA+stool 0 -0.619733677 0 yes serum_cytokines stool_bileacids 0.111 0.481 no no no no no no PDGF-bb Phospholipase D signaling pathway 0 0.481203008 0.443349754 yes serum_cytokines kegg 0.111 NA no no no no up up PDGF-bb Prevotella 0 0 0.412068087 yes acetate-producing serum_cytokines Genus 0.111 0.287 no no no no no no PDGF-bb Primary immunodeficiency 0 -0.515789474 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb Prolactin signaling pathway 0 0.44962406 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb Prostate cancer 0 0.47518797 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb Relaxin signaling pathway 0 0.545864662 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb Ruminococcus 0 -0.503896104 0 yes acetate-producing serum_cytokines Genus 0.111 0.335 no no no no no no PDGF-bb TNF signaling pathway 0 0.452631579 0 yes serum_cytokines kegg 0.111 NA no no no no no no PDGF-bb Transcriptional misregulation in cancer 0 0.485714286 0 yes serum_cytokines kegg 0.111 NA no no no no no no Pentose and glucuronate interconversions Citrate cycle (TCA cycle) 0.749565217 0.934782609 0.685714286 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Glycolysis / Gluconeogenesis 0.630434783 0.643280632 0 kegg kegg NA NA no no no no no no Pentose and glucuronate interconversions Pentose phosphate pathway 0 -0.613636364 -0.496525097 kegg kegg NA NA no no no no no no Pentose phosphate pathway Citrate cycle (TCA cycle) 0 -0.416007905 0 kegg kegg NA NA no no no no no no Peptoniphilus Anaerococcus 0 0.488459192 0 Genus Genus 0.183 0.275 no no no no no no Peptostreptococcus Peptoniphilus 0 0 0.581587125 Genus Genus 0.533 0.183 no no no no no no Peroxisome 2-Oxocarboxylic acid metabolism 0 -0.591897233 0 kegg kegg NA NA no no no no no no Peroxisome ABC transporters 0.433913043 0 0 kegg kegg NA NA no no no no up up Peroxisome "Alanine, aspartate and glutamate metabolism" 0.76173913 0.854743083 0.790733591 kegg kegg NA NA no no no no no no Peroxisome Alistipes -0.407864151 0 0 kegg Genus NA 0.0114 no no no no up no Peroxisome alpha-Linolenic acid metabolism 0.411304348 0.688735178 0 kegg kegg NA NA no no no no no no Peroxisome Arginine and proline metabolism 0.688695652 0.718379447 0 kegg kegg NA NA no no no no up no Peroxisome Arginine biosynthesis 0.799130435 0.83201581 0.775289575 kegg kegg NA NA no no no no no no Peroxisome Autophagy - animal 0 0.62944664 0 kegg kegg NA NA no no no no no no Peroxisome Biosynthesis of amino acids 0.540869565 0.743083004 0.688288288 kegg kegg NA NA no no no no no no Peroxisome Blautia 0.453043478 0.41798419 0 acetate-producing kegg Genus NA 1.36E-05 no no no up dn dn Peroxisome Butanoate metabolism 0 -0.433794466 0 kegg kegg NA NA no no no no no no Peroxisome Calcium signaling pathway -0.55826087 -0.747035573 -0.597683398 kegg kegg NA NA no no no no up up Peroxisome cAMP signaling pathway -0.506086957 0 0 yes kegg kegg NA NA no no no no up up Peroxisome Carbon metabolism 0 0 0.563449163 kegg kegg NA NA no no no no no no Peroxisome Cell cycle 0 -0.527667984 -0.554954955 kegg kegg NA NA no no no no no no Peroxisome cGMP-PKG signaling pathway 0 0.688735178 0 kegg kegg NA NA no no no no no no Peroxisome Chemokine signaling pathway 0 0.453557312 0 kegg kegg NA NA no no no no no no Peroxisome Clostridium 0.419926257 0 0 kegg Genus NA 0.925 no no no no no no Peroxisome Coprococcus 0 0 0.40671858 butyrate-producing kegg Genus NA 0.612 no no no no no no Peroxisome Cytokine-cytokine receptor interaction 0 0.500988142 0 kegg kegg NA NA no no no no no no Peroxisome DNA replication 0 -0.504940711 0 kegg kegg NA NA no no no no no no Peroxisome Drug metabolism - cytochrome P450 0 -0.529644269 0 kegg kegg NA NA no no no no no no Peroxisome Drug metabolism - other enzymes 0 -0.58201581 0 kegg kegg NA NA no no no no no no Peroxisome EGFR tyrosine kinase inhibitor resistance 0 -0.584980237 0 kegg kegg NA NA no no no no no no Peroxisome Endocrine resistance -0.573043478 0 0 kegg kegg NA NA no no no no no no Peroxisome Ether lipid metabolism -0.557391304 -0.468379447 0 kegg kegg NA NA no no no no no no Peroxisome Fatty acid biosynthesis 0.830434783 0.84486166 0.697297297 kegg kegg NA NA no no no no no no Peroxisome Fatty acid degradation 0.886086957 0.773715415 0.567824968 kegg kegg NA NA no no no no no no Peroxisome Fatty acid metabolism 0.862608696 0.836956522 0.528185328 kegg kegg NA NA no no no no no no Peroxisome Folate biosynthesis 0 -0.623517787 0 kegg kegg NA NA no no no no no no Peroxisome FoxO signaling pathway 0.525217391 0.564229249 0 kegg kegg NA NA no no no no no no Peroxisome Galactose metabolism 0.414782609 0.621541502 0 kegg kegg NA NA no no no no no no Peroxisome Glutathione metabolism 0 -0.566205534 0 kegg kegg NA NA no no no no no no Peroxisome Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.502608696 0.508893281 0 kegg kegg NA NA no no no no no no Peroxisome Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.586956522 -0.475418275 kegg kegg NA NA no no no no no no Peroxisome Glycosaminoglycan biosynthesis - keratan sulfate -0.553043478 -0.62944664 -0.579407979 kegg kegg NA NA no no no no no no Peroxisome Glycosaminoglycan degradation 0 0.43972332 0 kegg kegg NA NA no no no no no up Peroxisome Glyoxylate and dicarboxylate metabolism 0.832173913 0.837944664 0.778893179 kegg kegg NA NA no no no no no no Peroxisome HIF-1 signaling pathway 0 -0.482213439 0 kegg kegg NA NA no no no no no no Peroxisome Lysine degradation 0 0 -0.598712999 kegg kegg NA NA no no no no no no Peroxisome Lysosome 0 0.549407115 0.417503218 kegg kegg NA NA no no no no no no Peroxisome Mannose type O-glycan biosynthesis -0.43826087 0 -0.639382239 kegg kegg NA NA no no no no no no Peroxisome Metabolism of xenobiotics by cytochrome P450 0 -0.4743083 0 kegg kegg NA NA no no no no no no Peroxisome Mitophagy - animal -0.668695652 -0.501976285 0 kegg kegg NA NA no no no no no no Peroxisome mRNA surveillance pathway -0.487826087 -0.759881423 -0.656113256 kegg kegg NA NA no no no no no no Peroxisome N-Glycan biosynthesis 0 -0.738142292 -0.433204633 kegg kegg NA NA no no no no no no Peroxisome Neuroactive ligand-receptor interaction 0.459130435 0.640316206 0.584041184 kegg kegg NA NA no no no up up up Peroxisome NF-kappa B signaling pathway 0.445217391 0.596837945 0 kegg kegg NA NA no no no no no no Peroxisome Nicotinate and nicotinamide metabolism 0.872173913 0.789525692 0.636293436 kegg kegg NA NA no no no no no no Peroxisome Nitrogen metabolism 0.610434783 0.752964427 0.582496782 kegg kegg NA NA no no no no no no Peroxisome One carbon pool by folate 0 -0.479249012 0 kegg kegg NA NA no no no no no no Peroxisome Oocyte meiosis 0 0 -0.445559846 kegg kegg NA NA no no no no no no Peroxisome Oscillospira 0 0 0.415958816 LPS-producing kegg Genus NA 0.62 no no no no no no Peroxisome Other types of O-glycan biosynthesis 0 0 -0.471299871 kegg kegg NA NA no no no no no no Peroxisome Oxidative phosphorylation -0.548695652 -0.721343874 0 kegg kegg NA NA no no no no no no Peroxisome Pantothenate and CoA biosynthesis 0.780869565 0.866600791 0.695238095 kegg kegg NA NA no no no no no dn Peroxisome Paraprevotella 0 -0.429077812 0 kegg Genus NA 0.118 no no no no no no Peroxisome Pentose and glucuronate interconversions 0 -0.604743083 0 kegg kegg NA NA no no no no no no Peroxisome Pentose phosphate pathway 0 0.666996047 0.684942085 kegg kegg NA NA no no no no no no Peroxisome Phagosome 0 0.461462451 0 kegg kegg NA NA no no no no no no Peroxisome Phenylalanine metabolism 0 -0.434782609 0 kegg kegg NA NA no no no no no no Peroxisome Phosphatidylinositol signaling system 0 0 -0.528700129 kegg kegg NA NA no no no no no no Peroxisome PPAR signaling pathway 0.450434783 0.690711462 0 kegg kegg NA NA no no no no no no Peroxisome Protein export 0 -0.674901186 -0.425997426 kegg kegg NA NA no no no no no no Peroxisome Protein processing in endoplasmic reticulum -0.406086957 -0.747035573 0 kegg kegg NA NA no no no no no no Peroxisome Pyrimidine metabolism 0.520869565 -0.477272727 0 kegg kegg NA NA no no no no no no Peroxisome Pyruvate metabolism 0 -0.455533597 0 kegg kegg NA NA no no no no no no Peroxisome Ras signaling pathway 0 -0.688735178 -0.651222651 yes kegg kegg NA NA no no no no up up Peroxisome Retinol metabolism 0.436521739 0 0 kegg kegg NA NA no no no no no no Peroxisome Ribosome -0.586086957 -0.619565217 0 kegg kegg NA NA no no no no no no Peroxisome Ribosome biogenesis in eukaryotes 0 -0.441699605 -0.421879022 kegg kegg NA NA no no no no no no Peroxisome RNA degradation -0.48 -0.831027668 -0.615701416 kegg kegg NA NA no no no no no no Peroxisome RNA polymerase 0 -0.605731225 0 kegg kegg NA NA no no no no no no Peroxisome RNA transport 0 -0.500988142 0 kegg kegg NA NA no no no no no no Peroxisome Ruminococcus -0.54 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Peroxisome Starch and sucrose metabolism 0.590434783 0.838932806 0 kegg kegg NA NA no no no no no no Peroxisome Sulfur metabolism 0 0 0.45019305 kegg kegg NA NA no no no no no no Peroxisome Ubiquitin mediated proteolysis -0.76 -0.561264822 0 kegg kegg NA NA no no no no no no Peroxisome Various types of N-glycan biosynthesis 0 -0.583003953 0 kegg kegg NA NA no no no no no no Pertussis 2-Oxocarboxylic acid metabolism 0 -0.5 0 kegg kegg NA NA no no dn no no no Pertussis Adrenergic signaling in cardiomyocytes 0 -0.752964427 -0.462805663 kegg kegg NA NA no no dn no no up Pertussis AGE-RAGE signaling pathway in diabetic complications 0 0.708498024 0 kegg kegg NA NA no no dn no no no Pertussis Akkermansia 0.466952184 0 0 acetate-producing kegg Genus NA 0.23 no no dn no no no Pertussis "Alanine, aspartate and glutamate metabolism" 0.466956522 0.68972332 0.612612613 kegg kegg NA NA no no dn no no no Pertussis Aldosterone synthesis and secretion -0.460869565 -0.900197628 -0.434491634 kegg kegg NA NA no no dn no up up Pertussis alpha-Linolenic acid metabolism 0 0.51284585 0 kegg kegg NA NA no no dn no no no Pertussis Alzheimer disease -0.453913043 -0.67687747 -0.52020592 kegg kegg NA NA no no dn no no no Pertussis Aminoacyl-tRNA biosynthesis 0 -0.46541502 0 kegg kegg NA NA no no dn no no no Pertussis Amphetamine addiction -0.526086957 -0.83201581 0 kegg kegg NA NA no no dn no no no Pertussis AMPK signaling pathway -0.480869565 -0.653162055 0 kegg kegg NA NA no no dn no no no Pertussis Amyotrophic lateral sclerosis -0.523478261 -0.745059289 -0.502702703 kegg kegg NA NA no no dn no no no Pertussis Antifolate resistance 0 -0.604743083 -0.465379665 kegg kegg NA NA no no dn no no no Pertussis Antigen processing and presentation 0.511304348 0.416996047 0.529214929 kegg kegg NA NA no no dn no no no Pertussis Apelin signaling pathway -0.508695652 -0.605731225 -0.542342342 kegg kegg NA NA no no dn no no no Pertussis Apoptosis 0.529565217 0.768774704 0.706821107 kegg kegg NA NA no no dn no no no Pertussis Arginine and proline metabolism 0.490434783 0.754940711 0.585328185 kegg kegg NA NA no no dn no up no Pertussis Arginine biosynthesis 0.530434783 0.720355731 0.693178893 kegg kegg NA NA no no dn no no no Pertussis Autophagy - animal 0 0.462450593 0 kegg kegg NA NA no no dn no no no Pertussis B cell receptor signaling pathway 0 0.648221344 0 kegg kegg NA NA no no dn no no no Pertussis Basal transcription factors 0 -0.589920949 -0.692406692 kegg kegg NA NA no no dn no no no Pertussis Base excision repair 0 -0.613636364 -0.611068211 kegg kegg NA NA no no dn no no no Pertussis Biosynthesis of amino acids 0.655652174 0.907114625 0.798712999 kegg kegg NA NA no no dn no no no Pertussis Biosynthesis of cofactors 0 -0.648221344 0 kegg kegg NA NA no no dn no no no Pertussis Butanoate metabolism 0 -0.458498024 0 kegg kegg NA NA no no dn no no no Pertussis C-type lectin receptor signaling pathway 0 0.654150198 0 kegg kegg NA NA no no dn no no no Pertussis Calcium signaling pathway 0 -0.639328063 -0.438867439 kegg kegg NA NA no no dn no up up Pertussis Carbon metabolism 0.524347826 0.514822134 0.621364221 kegg kegg NA NA no no dn no no no Pertussis Cardiac muscle contraction -0.431304348 -0.682806324 -0.476190476 kegg kegg NA NA no no dn no no up Pertussis Cell adhesion molecules 0.499130435 0.718379447 0.51016731 kegg kegg NA NA no no dn no no no Pertussis Cell cycle -0.433043478 -0.831027668 -0.704247104 kegg kegg NA NA no no dn no no no Pertussis Cellular senescence 0.497391304 0.657114625 0 kegg kegg NA NA no no dn no no no Pertussis cGMP-PKG signaling pathway 0 0.910079051 0.483912484 kegg kegg NA NA no no dn no no no Pertussis Chemokine signaling pathway 0 0.634387352 0.542599743 kegg kegg NA NA no no dn no no no Pertussis Cholesterol metabolism 0 0.632411067 0 yes kegg kegg NA NA no no dn no no up Pertussis Circadian rhythm -0.406086957 -0.776679842 -0.704761905 kegg kegg NA NA no no dn no no no Pertussis Citrate cycle (TCA cycle) 0 -0.416007905 0 kegg kegg NA NA no no dn no no no Pertussis Cocaine addiction -0.497391304 -0.636363636 0 kegg kegg NA NA no no dn no no no Pertussis Complement and coagulation cascades 0.609565217 0.838932806 0.807979408 kegg kegg NA NA no no dn no no no Pertussis Cortisol synthesis and secretion -0.522608696 -0.71541502 0 kegg kegg NA NA no no dn no no up Pertussis Cushing syndrome -0.662608696 -0.846837945 -0.496782497 kegg kegg NA NA no no dn no no up Pertussis Cysteine and methionine metabolism 0 -0.461462451 -0.541827542 kegg kegg NA NA no no dn no no no Pertussis Cytokine-cytokine receptor interaction 0.456521739 0.451581028 0 kegg kegg NA NA no no dn no no no Pertussis DNA replication 0 -0.682806324 -0.63963964 kegg kegg NA NA no no dn no no no Pertussis Dopaminergic synapse 0 -0.608695652 0 kegg kegg NA NA no no dn no up no Pertussis Drug metabolism - cytochrome P450 0 -0.531620553 0 kegg kegg NA NA no no dn no no no Pertussis EGFR tyrosine kinase inhibitor resistance -0.583478261 -0.568181818 -0.507078507 kegg kegg NA NA no no dn no no no Pertussis Endocrine and other factor-regulated calcium reabsorption 0 -0.774703557 0 kegg kegg NA NA no no dn no no no Pertussis Endocrine resistance -0.428695652 -0.587944664 0 kegg kegg NA NA no no dn no no no Pertussis Endocytosis 0.57826087 0.763833992 0 kegg kegg NA NA no no dn no no no Pertussis Epithelial cell signaling in Helicobacter pylori infection 0.565217391 0.818181818 0.558558559 kegg kegg NA NA no no dn no no no Pertussis Estrogen signaling pathway 0 -0.498023715 0 kegg kegg NA NA no no dn no no no Pertussis Ether lipid metabolism -0.593913043 -0.618577075 -0.615701416 kegg kegg NA NA no no dn no no no Pertussis Fanconi anemia pathway 0 -0.57312253 -0.611583012 kegg kegg NA NA no no dn no no no Pertussis Fat digestion and absorption 0.607826087 0.764822134 0.432947233 yes kegg kegg NA NA no no dn no up up Pertussis Fatty acid biosynthesis 0.586086957 0.726284585 0.547232947 kegg kegg NA NA no no dn no no no Pertussis Fatty acid degradation 0.553043478 0.593873518 0 kegg kegg NA NA no no dn no no no Pertussis Fatty acid metabolism 0.58173913 0.695652174 0 kegg kegg NA NA no no dn no no no Pertussis Fc epsilon RI signaling pathway 0 0.759881423 0.405662806 kegg kegg NA NA no no dn no no no Pertussis Fc gamma R-mediated phagocytosis 0.750434783 0.903162055 0.867953668 kegg kegg NA NA no no dn no no no Pertussis Folate biosynthesis 0 -0.482213439 0 kegg kegg NA NA no no dn no no no Pertussis GABAergic synapse 0.522608696 0.52173913 0.599485199 kegg kegg NA NA no no dn no up up Pertussis Galactose metabolism 0 0.48715415 0 kegg kegg NA NA no no dn no no no Pertussis Glucagon signaling pathway -0.502608696 -0.900197628 -0.635263835 kegg kegg NA NA no no dn no no no Pertussis Glutathione metabolism 0 -0.605731225 0 kegg kegg NA NA no no dn no no no Pertussis Glycerolipid metabolism 0 0 -0.504247104 kegg kegg NA NA no no dn no no up Pertussis Glycerophospholipid metabolism 0 0 -0.595881596 kegg kegg NA NA no no dn no no up Pertussis "Glycine, serine and threonine metabolism" 0 -0.583003953 0 kegg kegg NA NA no no dn no up no Pertussis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.471304348 0.420948617 0 kegg kegg NA NA no no dn no no no Pertussis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.448616601 0 kegg kegg NA NA no no dn no no no Pertussis Glycosaminoglycan biosynthesis - keratan sulfate -0.45826087 -0.473320158 0 kegg kegg NA NA no no dn no no no Pertussis Glycosaminoglycan degradation 0.48 0.73715415 0 kegg kegg NA NA no no dn no no up Pertussis Glycosphingolipid biosynthesis - ganglio series 0 0 -0.418790219 kegg kegg NA NA no no dn no no no Pertussis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.570158103 -0.449420849 kegg kegg NA NA no no dn no no no Pertussis Glyoxylate and dicarboxylate metabolism 0.506956522 0.755928854 0.682882883 kegg kegg NA NA no no dn no no no Pertussis GnRH signaling pathway 0 -0.705533597 0 kegg kegg NA NA no no dn no no no Pertussis Hedgehog signaling pathway -0.435652174 -0.639328063 -0.640669241 kegg kegg NA NA no no dn no no no Pertussis Hippo signaling pathway - multiple species 0 0.608695652 0 kegg kegg NA NA no no dn no no no Pertussis Homologous recombination 0 0 -0.574774775 kegg kegg NA NA no no dn no no no Pertussis Huntington disease -0.494782609 -0.686758893 -0.457142857 kegg kegg NA NA no no dn no no no Pertussis IL-17 signaling pathway 0.575652174 0.894268775 0.74980695 kegg kegg NA NA no no dn no no no Pertussis Inflammatory mediator regulation of TRP channels 0 -0.740118577 0 kegg kegg NA NA no no dn no no no Pertussis Inositol phosphate metabolism 0 0 -0.534877735 kegg kegg NA NA no no dn no no no Pertussis Insulin secretion -0.573913043 -0.787549407 0 yes kegg kegg NA NA no no dn no up up Pertussis Insulin signaling pathway -0.527826087 -0.563241107 -0.518146718 kegg kegg NA NA no no dn no no no Pertussis Leukocyte transendothelial migration 0 0 0.589189189 kegg kegg NA NA no no dn no no no Pertussis Linoleic acid metabolism 0 -0.425889328 0 kegg kegg NA NA no no dn no no no Pertussis Longevity regulating pathway -0.416521739 0 0 kegg kegg NA NA no no dn no no no Pertussis Lysine degradation -0.573913043 -0.589920949 -0.718661519 kegg kegg NA NA no no dn no no no Pertussis Lysosome 0.547826087 0.889328063 0.688288288 kegg kegg NA NA no no dn no no no Pertussis Mannose type O-glycan biosynthesis -0.553043478 -0.53458498 -0.706821107 kegg kegg NA NA no no dn no no no Pertussis Melanogenesis -0.499130435 -0.759881423 0 kegg kegg NA NA no no dn no no no Pertussis Mineral absorption -0.420869565 -0.427865613 0 kegg kegg NA NA no no dn no no no Pertussis Mismatch repair 0 -0.486166008 0 kegg kegg NA NA no no dn no no no Pertussis Mitophagy - animal -0.590434783 -0.603754941 0 kegg kegg NA NA no no dn no no no Pertussis Morphine addiction 0 -0.64229249 0 kegg kegg NA NA no no dn no up up Pertussis mRNA surveillance pathway -0.574782609 -0.826086957 -0.823938224 kegg kegg NA NA no no dn no no no Pertussis mTOR signaling pathway -0.564347826 -0.54743083 -0.437065637 kegg kegg NA NA no no dn no no no Pertussis N-Glycan biosynthesis -0.474782609 -0.749011858 -0.562676963 kegg kegg NA NA no no dn no no no Pertussis Natural killer cell mediated cytotoxicity 0.583478261 0.701581028 0.412097812 kegg kegg NA NA no no dn no no no Pertussis Neuroactive ligand-receptor interaction 0.609565217 0.863636364 0.771171171 kegg kegg NA NA no no dn up up up Pertussis Neurotrophin signaling pathway 0 0.43083004 0 kegg kegg NA NA no no dn no no no Pertussis Neutrophil extracellular trap formation 0.705217391 0.882411067 0.829343629 kegg kegg NA NA no no dn no no no Pertussis NF-kappa B signaling pathway 0 0.493083004 0 kegg kegg NA NA no no dn no no no Pertussis Nicotinate and nicotinamide metabolism 0.624347826 0.781620553 0.650707851 kegg kegg NA NA no no dn no no no Pertussis Nicotine addiction 0 -0.494071146 0 kegg kegg NA NA no no dn no up up Pertussis Nitrogen metabolism 0.527826087 0.644268775 0.617760618 kegg kegg NA NA no no dn no no no Pertussis NOD-like receptor signaling pathway 0.672173913 0.730237154 0.564993565 kegg kegg NA NA no no dn no no no Pertussis Non-alcoholic fatty liver disease -0.466956522 -0.626482213 -0.465637066 kegg kegg NA NA no no dn no no no Pertussis Notch signaling pathway 0 0 -0.402316602 kegg kegg NA NA no no dn no no no Pertussis Nucleotide excision repair 0 -0.638339921 -0.635778636 kegg kegg NA NA no no dn no no no Pertussis Olfactory transduction 0.548695652 0.837944664 0.696010296 kegg kegg NA NA no no dn no no no Pertussis One carbon pool by folate 0 -0.670948617 -0.652252252 kegg kegg NA NA no no dn no no no Pertussis Oocyte meiosis 0 0 -0.426769627 kegg kegg NA NA no no dn no no no Pertussis Osteoclast differentiation 0.545217391 0.866600791 0.787644788 kegg kegg NA NA no no dn no no no Pertussis Other types of O-glycan biosynthesis -0.660869565 -0.648221344 -0.663835264 kegg kegg NA NA no no dn no no no Pertussis Ovarian steroidogenesis 0 -0.424901186 0 kegg kegg NA NA no no dn no up up Pertussis Oxidative phosphorylation -0.433913043 -0.64229249 -0.415444015 kegg kegg NA NA no no dn no no no Pertussis Oxytocin signaling pathway 0 0 0.446846847 kegg kegg NA NA no no dn no no no Pertussis p53 signaling pathway -0.42173913 0 -0.567567568 kegg kegg NA NA no no dn no no no Pertussis Pancreatic secretion 0 -0.643280632 0 kegg kegg NA NA no no dn no no no Pertussis Pantothenate and CoA biosynthesis 0.65826087 0.816205534 0.554954955 kegg kegg NA NA no no dn no no dn Pertussis "Parathyroid hormone synthesis, secretion and action" -0.493913043 -0.591897233 0 kegg kegg NA NA no no dn no no no Pertussis Parkinson disease -0.592173913 -0.640316206 0 kegg kegg NA NA no no dn no no no Pertussis Pathogenic Escherichia coli infection 0.664347826 0.790513834 0.617760618 kegg kegg NA NA no no dn no no no Pertussis Pathways of neurodegeneration - multiple diseases -0.599130435 -0.665019763 0 kegg kegg NA NA no no dn no no no Pertussis Pentose and glucuronate interconversions 0 -0.593873518 -0.415701416 kegg kegg NA NA no no dn no no no Pertussis Pentose phosphate pathway 0.586086957 0.915019763 0.742342342 kegg kegg NA NA no no dn no no no Pertussis Peroxisome 0.552173913 0.759881423 0.543886744 kegg kegg NA NA no no dn no no no Pertussis Phagosome 0.568695652 0.809288538 0.674388674 kegg kegg NA NA no no dn no no no Pertussis Phosphatidylinositol signaling system -0.453913043 -0.5256917 -0.662805663 kegg kegg NA NA no no dn no no no Pertussis PI3K-Akt signaling pathway 0 0 -0.491119691 yes kegg kegg NA NA no no dn no up up Pertussis Platinum drug resistance 0 0 -0.432689833 kegg kegg NA NA no no dn no no no Pertussis Porphyrin and chlorophyll metabolism 0 -0.511857708 0 kegg kegg NA NA no no dn no no no Pertussis PPAR signaling pathway 0.585217391 0.750988142 0.681081081 kegg kegg NA NA no no dn no no no Pertussis Prion disease 0 -0.639328063 0 kegg kegg NA NA no no dn no no no Pertussis Progesterone-mediated oocyte maturation 0 0 -0.43989704 kegg kegg NA NA no no dn no no no Pertussis Prolactin signaling pathway 0 0.59486166 0 kegg kegg NA NA no no dn no no no Pertussis Propanoate metabolism 0 0 -0.489317889 kegg kegg NA NA no no dn no no no Pertussis Protein digestion and absorption 0 0.670948617 0 yes kegg kegg NA NA no no dn no up up Pertussis Protein export -0.466956522 -0.535573123 -0.633719434 kegg kegg NA NA no no dn no no no Pertussis Protein processing in endoplasmic reticulum -0.469565217 -0.774703557 0 kegg kegg NA NA no no dn no no no Pertussis Proximal tubule bicarbonate reclamation 0 -0.638339921 0 kegg kegg NA NA no no dn no no no Pertussis Purine metabolism 0 -0.632411067 0 kegg kegg NA NA no no dn no no no Pertussis Pyrimidine metabolism 0 -0.553359684 0 kegg kegg NA NA no no dn no no no Pertussis Pyruvate metabolism 0 -0.555335968 -0.428828829 kegg kegg NA NA no no dn no no no Pertussis Ras signaling pathway 0 -0.537549407 -0.557528958 yes kegg kegg NA NA no no dn no up up Pertussis Regulation of lipolysis in adipocytes 0 -0.494071146 0 kegg kegg NA NA no no dn no no no Pertussis Renin secretion 0 -0.614624506 0 kegg kegg NA NA no no dn no no no Pertussis Renin-angiotensin system 0.613913043 0.915019763 0.613127413 kegg kegg NA NA no no dn no no no Pertussis Retrograde endocannabinoid signaling 0 -0.583003953 0 kegg kegg NA NA no no dn no no up Pertussis Ribosome -0.743478261 -0.598814229 -0.458687259 kegg kegg NA NA no no dn no no no Pertussis Ribosome biogenesis in eukaryotes -0.511304348 -0.758893281 -0.720978121 kegg kegg NA NA no no dn no no no Pertussis RIG-I-like receptor signaling pathway 0 0.51284585 0 kegg kegg NA NA no no dn no no no Pertussis RNA degradation -0.529565217 -0.803359684 -0.718918919 kegg kegg NA NA no no dn no no no Pertussis RNA polymerase -0.47826087 -0.852766798 -0.713513514 kegg kegg NA NA no no dn no no no Pertussis RNA transport 0 -0.464426877 0 kegg kegg NA NA no no dn no no no Pertussis Salmonella infection 0.692173913 0.754940711 0.583783784 kegg kegg NA NA no no dn no no no Pertussis Selenocompound metabolism 0 0 -0.553410553 kegg kegg NA NA no no dn no no no Pertussis Serotonergic synapse 0 0 0.467953668 kegg kegg NA NA no no dn no no no Pertussis Shigellosis -0.437391304 -0.419960474 0 kegg kegg NA NA no no dn no no no Pertussis Signaling pathways regulating pluripotency of stem cells -0.486086957 -0.414031621 -0.45045045 kegg kegg NA NA no no dn no no no Pertussis Sphingolipid signaling pathway 0 0.57312253 0 kegg kegg NA NA no no dn no no no Pertussis Spinocerebellar ataxia 0 -0.684782609 -0.551093951 kegg kegg NA NA no no dn no no no Pertussis Spliceosome 0 -0.422924901 -0.6002574 kegg kegg NA NA no no dn no no no Pertussis Starch and sucrose metabolism 0.493913043 0.7243083 0 kegg kegg NA NA no no dn no no no Pertussis Steroid biosynthesis 0 0 -0.439382239 kegg kegg NA NA no no dn no no no Pertussis Synaptic vesicle cycle 0 0.890316206 0.454568855 kegg kegg NA NA no no dn no up up Pertussis Synthesis and degradation of ketone bodies 0 -0.51284585 -0.412097812 kegg kegg NA NA no no dn no no no Pertussis Taste transduction 0 -0.608695652 -0.666924067 kegg kegg NA NA no no dn no no up Pertussis Taurine and hypotaurine metabolism -0.411304348 0 -0.487001287 kegg kegg NA NA no no dn no no no Pertussis Terpenoid backbone biosynthesis 0 0 -0.448391248 kegg kegg NA NA no no dn no no no Pertussis TGF-beta signaling pathway -0.529565217 -0.455533597 -0.445302445 kegg kegg NA NA no no dn no no no Pertussis Thermogenesis -0.546086957 -0.696640316 -0.462805663 kegg kegg NA NA no no dn no no no Pertussis Thiamine metabolism 0 -0.466403162 0 kegg kegg NA NA no no dn no no no Pertussis Thyroid hormone synthesis -0.47826087 -0.677865613 0 kegg kegg NA NA no no dn no no no Pertussis TNF signaling pathway 0 0.422924901 0 kegg kegg NA NA no no dn no no no Pertussis Toll-like receptor signaling pathway 0 0.725296443 0.54002574 yes kegg kegg NA NA no no dn no no no Pertussis Type I diabetes mellitus 0 0.648221344 0 kegg kegg NA NA no no dn no no no Pertussis Tyrosine metabolism 0 -0.453557312 0 kegg kegg NA NA no no dn no no no Pertussis Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.414031621 -0.577348777 kegg kegg NA NA no no dn no no no Pertussis Ubiquitin mediated proteolysis -0.670434783 -0.710474308 0 kegg kegg NA NA no no dn no no no Pertussis "Valine, leucine and isoleucine degradation" 0 -0.446640316 0 kegg kegg NA NA no no dn no no no Pertussis Various types of N-glycan biosynthesis 0 -0.616600791 0 kegg kegg NA NA no no dn no no no Pertussis Vascular smooth muscle contraction -0.435652174 -0.480237154 0 kegg kegg NA NA no no dn no no no Pertussis Vasopressin-regulated water reabsorption -0.423478261 -0.691699605 0 kegg kegg NA NA no no dn no no no Pertussis Viral protein interaction with cytokine and cytokine receptor 0.406086957 0.483201581 0 kegg kegg NA NA no no dn no no no Pertussis Wnt signaling pathway -0.56 -0.842885375 -0.683655084 kegg kegg NA NA no no dn no no no ph2 Eggerthella 0 0.414265972 0 Genus Genus 0.269 0.912 no no no no no no ph2 Finegoldia 0 0.501743098 0 Genus Genus 0.269 0.456 no no no no no no Phagosome alpha-Linolenic acid metabolism 0.437391304 0 0 kegg kegg NA NA no no no no no no Phagosome Aminoacyl-tRNA biosynthesis 0 -0.415019763 0 kegg kegg NA NA no no no no no no Phagosome Antifolate resistance 0 -0.431818182 -0.511454311 kegg kegg NA NA no no no no no no Phagosome Arginine and proline metabolism 0 0.432806324 0 kegg kegg NA NA no no no no up no Phagosome Arginine biosynthesis 0 0.420948617 0 kegg kegg NA NA no no no no no no Phagosome Autophagy - other -0.675652174 0 -0.590733591 kegg kegg NA NA no no no no no no Phagosome Basal transcription factors -0.75826087 -0.723320158 -0.813127413 kegg kegg NA NA no no no no no no Phagosome Base excision repair -0.46 -0.633399209 -0.635263835 kegg kegg NA NA no no no no no no Phagosome beta-Alanine metabolism 0.425217391 0 0 kegg kegg NA NA no no no no no no Phagosome Biosynthesis of amino acids 0.744347826 0.787549407 0.717374517 kegg kegg NA NA no no no no no no Phagosome Biosynthesis of cofactors 0 -0.808300395 0 kegg kegg NA NA no no no no no no Phagosome Butyricicoccus 0 0 0.439461115 butyrate-producing kegg Genus NA 0.852 no no no no no no Phagosome cAMP signaling pathway -0.467826087 0 0 yes kegg kegg NA NA no no no no up up Phagosome Carbon metabolism 0.568695652 0.635375494 0.602574003 kegg kegg NA NA no no no no no no Phagosome Cell cycle -0.716521739 -0.747035573 -0.642728443 kegg kegg NA NA no no no no no no Phagosome cGMP-PKG signaling pathway 0 0.73715415 0 kegg kegg NA NA no no no no no no Phagosome Chemokine signaling pathway 0 0.622529644 0.619305019 kegg kegg NA NA no no no no no no Phagosome DNA replication -0.456521739 -0.51284585 -0.583783784 kegg kegg NA NA no no no no no no Phagosome EGFR tyrosine kinase inhibitor resistance -0.46173913 0 0 kegg kegg NA NA no no no no no no Phagosome Endocrine resistance 0 -0.602766798 0 kegg kegg NA NA no no no no no no Phagosome Endocytosis 0.892173913 0.936758893 0.79047619 kegg kegg NA NA no no no no no no Phagosome Ether lipid metabolism -0.627826087 -0.79743083 -0.59021879 kegg kegg NA NA no no no no no no Phagosome Eubacterium 0 0 -0.406343288 kegg Genus NA 0.0692 no no no no no no Phagosome Fanconi anemia pathway -0.487826087 -0.661067194 -0.674388674 kegg kegg NA NA no no no no no no Phagosome Fatty acid biosynthesis 0 0.466403162 0 kegg kegg NA NA no no no no no no Phagosome Fatty acid metabolism 0.405217391 0 0 kegg kegg NA NA no no no no no no Phagosome Folate biosynthesis -0.43826087 0 0 kegg kegg NA NA no no no no no no Phagosome FoxO signaling pathway 0 0 -0.46023166 kegg kegg NA NA no no no no no no Phagosome Fructose and mannose metabolism 0.409565217 0 0 kegg kegg NA NA no no no no no no Phagosome Galactose metabolism 0.428695652 0.43083004 0 kegg kegg NA NA no no no no no no Phagosome Glutathione metabolism 0 -0.556324111 0 kegg kegg NA NA no no no no no no Phagosome Glycerophospholipid metabolism -0.54173913 -0.508893281 -0.587387387 kegg kegg NA NA no no no no no up Phagosome "Glycine, serine and threonine metabolism" 0 -0.718379447 0 kegg kegg NA NA no no no no up no Phagosome Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.46173913 0 0 kegg kegg NA NA no no no no no no Phagosome Glycosaminoglycan biosynthesis - keratan sulfate 0 0 -0.454054054 kegg kegg NA NA no no no no no no Phagosome Glycosaminoglycan degradation 0 0.604743083 0 kegg kegg NA NA no no no no no up Phagosome Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.411304348 -0.761857708 -0.476190476 kegg kegg NA NA no no no no no no Phagosome Glyoxylate and dicarboxylate metabolism 0 0.46541502 0 kegg kegg NA NA no no no no no no Phagosome Homologous recombination 0 -0.579051383 -0.725868726 kegg kegg NA NA no no no no no no Phagosome Inositol phosphate metabolism 0 0 -0.544658945 kegg kegg NA NA no no no no no no Phagosome Lysine degradation -0.435652174 -0.58201581 -0.621879022 kegg kegg NA NA no no no no no no Phagosome Lysosome 0.466956522 0.851778656 0.520720721 kegg kegg NA NA no no no no no no Phagosome Mannose type O-glycan biosynthesis 0 -0.43972332 -0.53024453 kegg kegg NA NA no no no no no no Phagosome Mismatch repair 0 -0.51284585 0 kegg kegg NA NA no no no no no no Phagosome Mitophagy - animal 0 -0.557312253 0 kegg kegg NA NA no no no no no no Phagosome mRNA surveillance pathway -0.779130435 -0.66798419 -0.676190476 kegg kegg NA NA no no no no no no Phagosome N-Glycan biosynthesis -0.56 -0.531620553 -0.468211068 kegg kegg NA NA no no no no no no Phagosome Neuroactive ligand-receptor interaction 0 0.800395257 0.488288288 kegg kegg NA NA no no no up up up Phagosome Nicotinate and nicotinamide metabolism 0 0.533596838 0.413899614 kegg kegg NA NA no no no no no no Phagosome Nitrogen metabolism 0.52 0 0 kegg kegg NA NA no no no no no no Phagosome Nucleotide excision repair -0.46 -0.640316206 -0.674903475 kegg kegg NA NA no no no no no no Phagosome One carbon pool by folate -0.455652174 -0.612648221 -0.501415701 kegg kegg NA NA no no no no no no Phagosome Oocyte meiosis -0.662608696 0 -0.452767053 kegg kegg NA NA no no no no no no Phagosome Other types of O-glycan biosynthesis -0.693913043 -0.695652174 -0.720978121 kegg kegg NA NA no no no no no no Phagosome Oxidative phosphorylation -0.557391304 -0.418972332 0 kegg kegg NA NA no no no no no no Phagosome p53 signaling pathway -0.625217391 -0.578063241 -0.767310167 kegg kegg NA NA no no no no no no Phagosome Pantothenate and CoA biosynthesis 0 0.511857708 0 kegg kegg NA NA no no no no no dn Phagosome Pentose and glucuronate interconversions 0 -0.434782609 0 kegg kegg NA NA no no no no no no Phagosome Pentose phosphate pathway 0.699130435 0.876482213 0.557271557 kegg kegg NA NA no no no no no no Phagosome Phosphatidylinositol signaling system -0.605217391 -0.481225296 -0.667953668 kegg kegg NA NA no no no no no no Phagosome Platinum drug resistance -0.42173913 -0.444664032 -0.691634492 kegg kegg NA NA no no no no no no Phagosome Porphyrin and chlorophyll metabolism 0 -0.693675889 0 kegg kegg NA NA no no no no no no Phagosome PPAR signaling pathway 0 0.572134387 0.560617761 kegg kegg NA NA no no no no no no Phagosome Protein export -0.812173913 0 0 kegg kegg NA NA no no no no no no Phagosome Protein processing in endoplasmic reticulum -0.442608696 -0.656126482 0 kegg kegg NA NA no no no no no no Phagosome Purine metabolism 0 -0.761857708 0 kegg kegg NA NA no no no no no no Phagosome Pyrimidine metabolism 0 -0.494071146 0 kegg kegg NA NA no no no no no no Phagosome Rap1 signaling pathway 0.507826087 0 0.52998713 kegg kegg NA NA no no no no no no Phagosome Ras signaling pathway 0 0 -0.563449163 yes kegg kegg NA NA no no no no up up Phagosome Ribosome -0.626086957 0 0 kegg kegg NA NA no no no no no no Phagosome Ribosome biogenesis in eukaryotes -0.66173913 -0.683794466 -0.653796654 kegg kegg NA NA no no no no no no Phagosome RNA degradation -0.734782609 -0.566205534 -0.524324324 kegg kegg NA NA no no no no no no Phagosome RNA polymerase -0.697391304 -0.735177866 -0.635006435 kegg kegg NA NA no no no no no no Phagosome Ruminococcus 0 0 0.468211068 acetate-producing kegg Genus NA 0.335 no no no no no no Phagosome Selenocompound metabolism -0.623478261 -0.591897233 -0.643758044 kegg kegg NA NA no no no no no no Phagosome Sphingolipid signaling pathway 0 0.68972332 0 kegg kegg NA NA no no no no no no Phagosome Spliceosome -0.56 -0.511857708 -0.640926641 kegg kegg NA NA no no no no no no Phagosome Starch and sucrose metabolism 0 0.462450593 0 kegg kegg NA NA no no no no no no Phagosome Steroid biosynthesis -0.704347826 0 -0.418275418 kegg kegg NA NA no no no no no no Phagosome Synthesis and degradation of ketone bodies 0 -0.559288538 -0.523552124 kegg kegg NA NA no no no no no no Phagosome Taurine and hypotaurine metabolism -0.440869565 0 -0.42033462 kegg kegg NA NA no no no no no no Phagosome Terpenoid backbone biosynthesis -0.753913043 0 -0.512226512 kegg kegg NA NA no no no no no no Phagosome Thiamine metabolism 0 -0.479249012 0 kegg kegg NA NA no no no no no no Phagosome Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.438735178 -0.537194337 kegg kegg NA NA no no no no no no Phagosome Ubiquitin mediated proteolysis -0.413913043 -0.666007905 0 kegg kegg NA NA no no no no no no Phagosome Various types of N-glycan biosynthesis -0.526086957 0 0 kegg kegg NA NA no no no no no no Phenaceturic acid+urine 2-hydroxyhippuric acid+urine -0.514285714 0 0 urine_cometabolism urine_cometabolism 0.737 0.215 no no no no no no Phenaceturic acid+urine DL-Indole-3-lactic acid+urine 0 0.461403509 0 urine_cometabolism urine_cometabolism 0.737 0.00552 no no no up up no Phenaceturic acid+urine Homovanillic acid+urine -0.536842105 0 0 urine_cometabolism urine_cometabolism 0.737 0.45 no no no no no no Phenaceturic acid+urine L-Phenylalanine+urine 0 -0.457894737 0 urine_cometabolism urine_cometabolism 0.737 0.0908 no no no no up no Phenylacetic acid+stool 4-hydroxybenzoic acid+stool 0 0 -0.62055336 stool_cometabolism stool_cometabolism 0.785 0.0536 no no no no dn no Phenylacetic acid+stool Acetic acid+stool -0.469556244 0 -0.60770751 yes stool_cometabolism stool_scfa 0.785 0.0656 no no no dn no no Phenylacetic acid+stool Alistipes 0.480869694 0 0 stool_cometabolism Genus 0.785 0.0114 no no no no up no Phenylacetic acid+stool Allograft rejection 0 0 -0.491812535 stool_cometabolism kegg 0.785 NA no no no no no no Phenylacetic acid+stool Autoimmune thyroid disease 0 0 -0.491812535 stool_cometabolism kegg 0.785 NA no no no no no no Phenylacetic acid+stool Butyric acid+stool 0 0 -0.447628458 yes stool_cometabolism stool_scfa 0.785 0.102 no no no dn no no Phenylacetic acid+stool Butyricicoccus 0 0 -0.426403016 butyrate-producing stool_cometabolism Genus 0.785 0.852 no no no no no no Phenylacetic acid+stool CA+stool 0 0 -0.475296443 stool_cometabolism stool_bileacids 0.785 0.827 no no no no no no Phenylacetic acid+stool Caproic acid+stool 0 0.622377622 0 stool_cometabolism stool_scfa 0.785 0.882 no no no no no no Phenylacetic acid+stool CDCA+stool 0 -0.692307692 -0.677865613 stool_cometabolism stool_bileacids 0.785 0.663 no no no no no no Phenylacetic acid+stool Cell adhesion molecules 0 0 -0.516657256 stool_cometabolism kegg 0.785 NA no no no no no no Phenylacetic acid+stool Cellular senescence 0 0 -0.462450593 stool_cometabolism kegg 0.785 NA no no no no no no Phenylacetic acid+stool Central carbon metabolism in cancer -0.523219814 0 0 stool_cometabolism kegg 0.785 NA no no no no no no Phenylacetic acid+stool Coprococcus -0.620227038 0 0 butyrate-producing stool_cometabolism Genus 0.785 0.612 no no no no no no Phenylacetic acid+stool Endocytosis 0 0 -0.464709204 stool_cometabolism kegg 0.785 NA no no no no no no Phenylacetic acid+stool Faecalibacterium 0 -0.671328671 -0.460929998 butyrate-producing stool_cometabolism Genus 0.785 0.0039 no no no no dn dn Phenylacetic acid+stool GCDCA+stool 0 -0.93006993 0 yes stool_cometabolism stool_bileacids 0.785 0.0471 no no no no dn no Phenylacetic acid+stool GDCA+stool 0 -0.59895013 0 stool_cometabolism stool_bileacids 0.785 0.656 no no no no no no Phenylacetic acid+stool Graft-versus-host disease 0 0 -0.497459063 stool_cometabolism kegg 0.785 NA no no no no no no Phenylacetic acid+stool GUDCA+stool 0.518098316 0 0 yes stool_cometabolism stool_bileacids 0.785 0.0085 no no no no dn no Phenylacetic acid+stool Indole-3-Acetic acid+stool 0.711042312 0.741258741 0.693675889 stool_cometabolism stool_cometabolism 0.785 0.304 no no no no no no Phenylacetic acid+stool Intestinal immune network for IgA production 0 -0.618181818 0 stool_cometabolism kegg 0.785 NA no no no no no no Phenylacetic acid+stool iso-LCA+stool 0 0 0.449604743 stool_cometabolism stool_bileacids 0.785 0.72 no no no no no no Phenylacetic acid+stool Isobutyric acid+stool 0.849329205 0.881118881 0.860671937 stool_cometabolism stool_scfa 0.785 0.408 no no no no no no Phenylacetic acid+stool Isovaleric acid+stool 0.791537668 0.951048951 0.881422925 stool_cometabolism stool_scfa 0.785 0.343 no no no no no no Phenylacetic acid+stool L-Phenylalanine+stool 0.486068111 0.685314685 0.670948617 stool_cometabolism stool_cometabolism 0.785 0.398 no no no no no no Phenylacetic acid+stool L-Tryptophan+stool 0.574819401 0 0.716403162 stool_cometabolism stool_cometabolism 0.785 0.557 no no no no no no Phenylacetic acid+stool L-Tyrosine+stool 0 0 0.57312253 stool_cometabolism stool_cometabolism 0.785 0.44 no no no no no no Phenylacetic acid+stool Legionellosis -0.525283798 0 0 stool_cometabolism kegg 0.785 NA no no no no no no Phenylacetic acid+stool nutriCA+stool 0 0 -0.504940711 stool_cometabolism stool_bileacids 0.785 0.481 no no no no no no Phenylacetic acid+stool Parabacteroides 0 0.629370629 0 stool_cometabolism Genus 0.785 4.19E-05 no no no no up up Phenylacetic acid+stool Pathways in cancer 0 0 0.473743648 stool_cometabolism kegg 0.785 NA no no no no no no Phenylacetic acid+stool PI3K-Akt signaling pathway -0.471620227 0 0 yes stool_cometabolism kegg 0.785 NA no no no no up up Phenylacetic acid+stool Primary immunodeficiency -0.533539732 0 0 stool_cometabolism kegg 0.785 NA no no no no no no Phenylacetic acid+stool Roseburia 0 -0.858144924 0 butyrate-producing stool_cometabolism Genus 0.785 0.495 no no no no no no Phenylacetic acid+stool Type I diabetes mellitus 0 0 -0.501976285 stool_cometabolism kegg 0.785 NA no no no no no no Phenylacetic acid+stool Viral myocarditis 0 0 -0.492941841 stool_cometabolism kegg 0.785 NA no no no no no no Phenylacetyl L-GlutaMine+urine 12-HEPE+blood 0 0 0.481393452 urine_cometabolism serum_ARA 0.0909 0.312 up no no no no no Phenylacetyl L-GlutaMine+urine "12,13-EPOME+blood" 0 0 0.435445287 urine_cometabolism serum_ARA 0.0909 0.901 up no no no no no Phenylacetyl L-GlutaMine+urine 13-HODE+blood 0 0.565934066 0 urine_cometabolism serum_ARA 0.0909 0.32 up no no no no no Phenylacetyl L-GlutaMine+urine 15-HETE+blood 0 0 -0.4640622 urine_cometabolism serum_ARA 0.0909 0.819 up no no no no no Phenylacetyl L-GlutaMine+urine 16:0/18:1-PC+blood 0.50245098 0.648351648 0 urine_cometabolism serum_phospholipids 0.0909 6.15E-07 up no no up up up Phenylacetyl L-GlutaMine+urine 16:0/18:2-PC+blood 0.490196078 0.686813187 0 urine_cometabolism serum_phospholipids 0.0909 3.24E-06 up no no no up up Phenylacetyl L-GlutaMine+urine 16:0/20:4-PI+blood -0.605392157 0 0 urine_cometabolism serum_phospholipids 0.0909 0.558 up no no no no no Phenylacetyl L-GlutaMine+urine 16:1/18:2-PG+blood 0.507352941 0 0 urine_cometabolism serum_phospholipids 0.0909 1.40E-08 up no no no up up Phenylacetyl L-GlutaMine+urine 18:0-LPC+blood 0 -0.71978022 0 urine_cometabolism serum_phospholipids 0.0909 0.554 up no no no no no Phenylacetyl L-GlutaMine+urine 18:0-LPE+blood 0 0 -0.433766234 urine_cometabolism serum_phospholipids 0.0909 0.491 up no no no no no Phenylacetyl L-GlutaMine+urine 18:0/16:0-PC+blood 0 0.604395604 0 urine_cometabolism serum_phospholipids 0.0909 9.64E-07 up no no up up up Phenylacetyl L-GlutaMine+urine 18:0/18:1-PE+blood 0 -0.554945055 0 urine_cometabolism serum_phospholipids 0.0909 0.00716 up no no up up no Phenylacetyl L-GlutaMine+urine 18:0/18:2-PC+blood 0.512254902 0 0 urine_cometabolism serum_phospholipids 0.0909 1.74E-06 up no no no up up Phenylacetyl L-GlutaMine+urine 18:1-LPE+blood 0 0 -0.515584416 urine_cometabolism serum_phospholipids 0.0909 0.117 up no no no no no Phenylacetyl L-GlutaMine+urine 18:1/16:0-PC+blood 0.490196078 0.67032967 0 urine_cometabolism serum_phospholipids 0.0909 2.43E-05 up no no no up up Phenylacetyl L-GlutaMine+urine 18:1/18:0-PC+blood 0.492647059 0 0 urine_cometabolism serum_phospholipids 0.0909 1.83E-06 up no no no up up Phenylacetyl L-GlutaMine+urine 18:2n6c+blood 0 0 0.451948052 urine_cometabolism serum_fattyacid 0.0909 0.15 up no no no no no Phenylacetyl L-GlutaMine+urine 18:3n3+blood 0 0 0.497402597 urine_cometabolism serum_fattyacid 0.0909 0.291 up no no no no no Phenylacetyl L-GlutaMine+urine 18:3n6+blood -0.534313725 -0.686813187 -0.477922078 urine_cometabolism serum_fattyacid 0.0909 0.0463 up no no up no dn Phenylacetyl L-GlutaMine+urine 2-hydroxyphenylacetic acid+urine -0.446616541 0 0 urine_cometabolism urine_cometabolism 0.0909 0.763 up no no no no no Phenylacetyl L-GlutaMine+urine 20:3n6+blood -0.50245098 0 0 urine_cometabolism serum_fattyacid 0.0909 0.0884 up no no up no no Phenylacetyl L-GlutaMine+urine 4-hydroxybenzoic acid+stool 0 0 -0.574819401 urine_cometabolism stool_cometabolism 0.0909 0.0536 up no no no dn no Phenylacetyl L-GlutaMine+urine 8-HETE+blood 0 0.642857143 0 urine_cometabolism serum_ARA 0.0909 0.741 up no no no no no Phenylacetyl L-GlutaMine+urine 9-HODE+blood 0 0.714285714 0 urine_cometabolism serum_ARA 0.0909 0.297 up no no no no no Phenylacetyl L-GlutaMine+urine Adherens junction 0.663157895 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Adrenergic signaling in cardiomyocytes 0 0 -0.426153846 urine_cometabolism kegg 0.0909 NA up no no no no up Phenylacetyl L-GlutaMine+urine Alistipes 0.557229548 0 0 urine_cometabolism Genus 0.0909 0.0114 up no no no up no Phenylacetyl L-GlutaMine+urine Alzheimer disease 0 -0.494736842 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Amoebiasis 0 0.459649123 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Apelin signaling pathway 0 -0.684210526 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Arrhythmogenic right ventricular cardiomyopathy 0.598245614 0 0 urine_cometabolism kegg 0.0909 NA up no no no up up Phenylacetyl L-GlutaMine+urine Autophagy - animal -0.542105263 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Bacterial invasion of epithelial cells 0.521052632 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine CA+blood 0 -0.762036484 0 urine_cometabolism serum_bileacids 0.0909 0.606 up no no no no no Phenylacetyl L-GlutaMine+urine CDCA+blood 0 -0.648351648 0 urine_cometabolism serum_bileacids 0.0909 0.506 up no no no no no Phenylacetyl L-GlutaMine+urine CDCA+stool 0 0 -0.488132095 urine_cometabolism stool_bileacids 0.0909 0.663 up no no no no no Phenylacetyl L-GlutaMine+urine Central carbon metabolism in cancer 0 -0.496491228 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Cholinergic synapse -0.514035088 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Coprococcus -0.476691729 0 0 butyrate-producing urine_cometabolism Genus 0.0909 0.612 up no no no no no Phenylacetyl L-GlutaMine+urine Coronavirus disease - COVID-19 0 -0.568421053 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine d18:1-16:1-SM+blood 0 -0.582417582 0 urine_cometabolism serum_phospholipids 0.0909 0.2 up no no no no no Phenylacetyl L-GlutaMine+urine d18:1-18:1-SM+blood 0 0 -0.471428571 urine_cometabolism serum_phospholipids 0.0909 0.916 up no no no no no Phenylacetyl L-GlutaMine+urine DHA+blood 0 0.576923077 0 urine_cometabolism serum_ARA 0.0909 0.872 up no no no no no Phenylacetyl L-GlutaMine+urine Diabetic cardiomyopathy 0 -0.528070175 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Dilated cardiomyopathy 0.589473684 0 0 urine_cometabolism kegg 0.0909 NA up no no no up up Phenylacetyl L-GlutaMine+urine DPA+blood 0 0.774725275 0 urine_cometabolism serum_ARA 0.0909 0.519 up no no no no no Phenylacetyl L-GlutaMine+urine EGFR tyrosine kinase inhibitor resistance 0 -0.750877193 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Ethanolamine+blood 0.590686275 0.741758242 0 urine_cometabolism serum_aminoacids 0.0909 0.122 up no no up no no Phenylacetyl L-GlutaMine+urine Faecalibacterium -0.448120301 0 -0.4054055 butyrate-producing urine_cometabolism Genus 0.0909 0.0039 up no no no dn dn Phenylacetyl L-GlutaMine+urine Focal adhesion 0.635087719 0 0 urine_cometabolism kegg 0.0909 NA up no no no up up Phenylacetyl L-GlutaMine+urine FoxO signaling pathway 0 0 0.424615385 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine GABAergic synapse -0.557894737 0 0 urine_cometabolism kegg 0.0909 NA up no no no up up Phenylacetyl L-GlutaMine+urine Gastric acid secretion 0.547368421 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine GCA+blood 0 -0.703296703 0 yes urine_cometabolism serum_bileacids 0.0909 0.16 up no no no no no Phenylacetyl L-GlutaMine+urine GCDCA+blood 0 -0.615384615 0 urine_cometabolism serum_bileacids 0.0909 0.31 up no no no no no Phenylacetyl L-GlutaMine+urine GDCA+blood 0 0 0.54025974 urine_cometabolism serum_bileacids 0.0909 0.632 up no no no no no Phenylacetyl L-GlutaMine+urine Glutamatergic synapse 0 0.478947368 0 urine_cometabolism kegg 0.0909 NA up no no no up up Phenylacetyl L-GlutaMine+urine Glutathione metabolism 0 -0.49122807 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Glycolysis / Gluconeogenesis 0 -0.498245614 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine HCA+blood 0 -0.672584793 0 urine_cometabolism serum_bileacids 0.0909 0.544 up no no no no no Phenylacetyl L-GlutaMine+urine Hepatocellular carcinoma 0.670175439 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine HIF-1 signaling pathway 0 -0.735087719 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Hippo signaling pathway 0.705263158 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Hippuric acid+urine 0 0 0.443418803 urine_cometabolism urine_cometabolism 0.0909 0.361 up no no no no no Phenylacetyl L-GlutaMine+urine Homovanillic acid+urine -0.718796992 0 -0.504957265 urine_cometabolism urine_cometabolism 0.0909 0.45 up no no no no no Phenylacetyl L-GlutaMine+urine Human papillomavirus infection 0 0.485964912 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Hypertrophic cardiomyopathy 0.550877193 0 0 urine_cometabolism kegg 0.0909 NA up no no no up up Phenylacetyl L-GlutaMine+urine Indole-3-Acetic acid+urine 0 0.563157895 0 urine_cometabolism urine_cometabolism 0.0909 0.657 up no no no no no Phenylacetyl L-GlutaMine+urine Influenza A 0.703508772 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Insulin signaling pathway 0 -0.757894737 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine iso-LCA+blood 0 0 0.44882074 urine_cometabolism serum_bileacids 0.0909 0.507 up no no no no no Phenylacetyl L-GlutaMine+urine iso-LCA+stool 0 0 0.591331269 urine_cometabolism stool_bileacids 0.0909 0.72 up no no no no no Phenylacetyl L-GlutaMine+urine JAK-STAT signaling pathway 0 0.50877193 0.449230769 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine L-Phenylalanine+stool 0.63956044 0 0.5500516 urine_cometabolism stool_cometabolism 0.0909 0.398 up no no no no no Phenylacetyl L-GlutaMine+urine L-Phenylalanine+urine 0 -0.484210526 0 urine_cometabolism urine_cometabolism 0.0909 0.0908 up no no no up no Phenylacetyl L-GlutaMine+urine L-Tryptophan+blood 0 0 0.441558442 urine_cometabolism serum_aminoacids 0.0909 0.164 up no no no no no Phenylacetyl L-GlutaMine+urine L-Tryptophan+stool 0.714285714 0 0 urine_cometabolism stool_cometabolism 0.0909 0.557 up no no no no no Phenylacetyl L-GlutaMine+urine L-Tyrosine+stool 0.674725275 0 0.494324045 urine_cometabolism stool_cometabolism 0.0909 0.44 up no no no no no Phenylacetyl L-GlutaMine+urine LCA+blood 0 0 0.660407016 urine_cometabolism serum_bileacids 0.0909 0.884 up no no no no no Phenylacetyl L-GlutaMine+urine Legionellosis 0 -0.521052632 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Leishmaniasis 0 -0.484210526 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Leukocyte transendothelial migration 0.475438596 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Long-term potentiation 0 -0.542105263 0 urine_cometabolism kegg 0.0909 NA up no no no no up Phenylacetyl L-GlutaMine+urine mTOR signaling pathway 0 -0.79122807 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine n3+blood 0 0 0.588311688 urine_cometabolism serum_fattyacid 0.0909 0.806 up no no no no no Phenylacetyl L-GlutaMine+urine Nicotinamide+urine 0 0 -0.448888889 urine_cometabolism urine_cometabolism 0.0909 0.721 up no no no no no Phenylacetyl L-GlutaMine+urine Non-small cell lung cancer 0 0.459649123 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine nutriCA+blood 0 -0.583853171 0 urine_cometabolism serum_bileacids 0.0909 0.726 up no no no no no Phenylacetyl L-GlutaMine+urine nutriCA+stool 0 0 -0.607843137 urine_cometabolism stool_bileacids 0.0909 0.481 up no no no no no Phenylacetyl L-GlutaMine+urine Oocyte meiosis 0 -0.536842105 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Oscillospira 0 0 0.540512821 LPS-producing urine_cometabolism Genus 0.0909 0.62 up no no no no no Phenylacetyl L-GlutaMine+urine Oxidative phosphorylation 0 -0.503508772 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Oxytocin signaling pathway 0.503508772 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Parabacteroides 0.481203008 0 0 urine_cometabolism Genus 0.0909 4.19E-05 up no no no up up Phenylacetyl L-GlutaMine+urine "Parathyroid hormone synthesis, secretion and action" 0 -0.540350877 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Phenaceturic acid+urine 0.667669173 0.561403509 0 urine_cometabolism urine_cometabolism 0.0909 0.737 up no no no no no Phenylacetyl L-GlutaMine+urine Phenylacetic acid+stool 0.582417582 0 0.713106295 urine_cometabolism stool_cometabolism 0.0909 0.785 up no no no no no Phenylacetyl L-GlutaMine+urine Phospholipase D signaling pathway 0 0.587719298 0 urine_cometabolism kegg 0.0909 NA up no no no up up Phenylacetyl L-GlutaMine+urine PI3K-Akt signaling pathway 0 -0.471929825 0 yes urine_cometabolism kegg 0.0909 NA up no no no up up Phenylacetyl L-GlutaMine+urine Platelet activation 0.501754386 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Prion disease 0 -0.549122807 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Proteoglycans in cancer 0 -0.556140351 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine PUFA%+blood 0 0.604395604 0 urine_cometabolism serum_fattyacid 0.0909 0.0013 up no no dn no up Phenylacetyl L-GlutaMine+urine Rap1 signaling pathway 0.505263158 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Renal cell carcinoma 0 -0.463157895 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Retrograde endocannabinoid signaling 0 -0.456140351 0 urine_cometabolism kegg 0.0909 NA up no no no no up Phenylacetyl L-GlutaMine+urine Ribosome 0 -0.563157895 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine RNA degradation 0 -0.473684211 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine RNA transport 0 -0.726315789 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Sarcosine+blood 0 0 -0.518181818 urine_cometabolism serum_choline 0.0909 5.06E-05 up no no up up no Phenylacetyl L-GlutaMine+urine Serine+blood 0 0.593406593 0 urine_cometabolism serum_aminoacids 0.0909 0.942 up no no no no no Phenylacetyl L-GlutaMine+urine SFA%+blood 0 0.571428571 0 urine_cometabolism serum_fattyacid 0.0909 0.0236 up no no no up no Phenylacetyl L-GlutaMine+urine Spinocerebellar ataxia -0.587719298 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Staphylococcus aureus infection 0.603508772 0 0 urine_cometabolism kegg 0.0909 NA up no no up no no Phenylacetyl L-GlutaMine+urine Taurine+blood 0.558823529 0.631868132 0 urine_cometabolism serum_aminoacids 0.0909 0.857 up no no no no no Phenylacetyl L-GlutaMine+urine TDCA+blood 0 0 0.526108192 yes urine_cometabolism serum_bileacids 0.0909 0.155 up no no no up no Phenylacetyl L-GlutaMine+urine Thermogenesis 0 -0.473684211 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine Thyroid hormone signaling pathway 0.712280702 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine TMAO+blood 0 0 0.57012987 urine_cometabolism serum_choline 0.0909 0.00706 up no no up up no Phenylacetyl L-GlutaMine+urine Transcriptional misregulation in cancer -0.496491228 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylacetyl L-GlutaMine+urine UDCA+stool 0 0 -0.622291022 urine_cometabolism stool_bileacids 0.0909 0.266 up no no no no no Phenylacetyl L-GlutaMine+urine UFA%+blood 0 0.56043956 0 urine_cometabolism serum_fattyacid 0.0909 0.0236 up no no no dn no Phenylacetyl L-GlutaMine+urine Valine+blood 0 0 0.515584416 yes urine_cometabolism serum_aminoacids 0.0909 1.22E-06 up no no up up no Phenylacetyl L-GlutaMine+urine Vibrio cholerae infection 0.545614035 0 0 urine_cometabolism kegg 0.0909 NA up no no no no no Phenylalanine metabolism "Alanine, aspartate and glutamate metabolism" 0 -0.583992095 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Arginine and proline metabolism 0 -0.564229249 0 kegg kegg NA NA no no no no up no Phenylalanine metabolism Arginine biosynthesis 0 -0.596837945 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Ascorbate and aldarate metabolism 0.52 0.679841897 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Citrate cycle (TCA cycle) 0.705217391 0.856719368 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Cysteine and methionine metabolism 0 0.710474308 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Fatty acid biosynthesis 0 -0.519762846 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Fatty acid elongation 0.602608696 0.614624506 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Fructose and mannose metabolism 0.513043478 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Galactose metabolism 0.548695652 0 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism "Glycine, serine and threonine metabolism" 0.446086957 0 0 kegg kegg NA NA no no no no up no Phenylalanine metabolism Glycolysis / Gluconeogenesis 0.664347826 0.692687747 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Histidine metabolism 0.535652174 0 0.6 kegg kegg NA NA no no no no no no Phenylalanine metabolism Pentose and glucuronate interconversions 0.685217391 0.81027668 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Primary bile acid biosynthesis 0.551304348 0.626482213 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Pyrimidine metabolism 0.450434783 0.685770751 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Steroid biosynthesis 0 0.670948617 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Steroid hormone biosynthesis 0.482608696 0.792490119 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Synthesis and degradation of ketone bodies 0.416521739 0.666996047 0 kegg kegg NA NA no no no no no no Phenylalanine metabolism Tyrosine metabolism 0.806086957 0.863636364 0.541055341 kegg kegg NA NA no no no no no no Phenylalanine metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.630434783 0.830039526 0.41956242 kegg kegg NA NA no no no no no no Phenylalanine metabolism "Valine, leucine and isoleucine degradation" 0.657391304 0.882411067 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system 2-Oxocarboxylic acid metabolism -0.446086957 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system ABC transporters 0 0.510869565 0.475418275 kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system "Alanine, aspartate and glutamate metabolism" 0 0 -0.474131274 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system alpha-Linolenic acid metabolism -0.733913043 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Amino sugar and nucleotide sugar metabolism -0.637391304 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Aminoacyl-tRNA biosynthesis 0 0.5256917 0.438095238 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Antifolate resistance 0 0.57312253 0.557014157 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Arachidonic acid metabolism 0 -0.434782609 -0.578635779 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Arginine and proline metabolism -0.486956522 -0.451581028 0 kegg kegg NA NA no no no no up no Phosphatidylinositol signaling system Arginine biosynthesis 0 0 -0.62007722 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Ascorbate and aldarate metabolism 0 0 0.457142857 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Basal transcription factors 0.531304348 0.729249012 0.753925354 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Base excision repair 0 0.704545455 0.506821107 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system beta-Alanine metabolism -0.612173913 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Biosynthesis of amino acids -0.773913043 -0.519762846 -0.78043758 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Butanoate metabolism -0.444347826 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Calcium signaling pathway 0.769565217 0 0 kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system cAMP signaling pathway 0.56 -0.464426877 0 yes kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system Carbon metabolism -0.706956522 0 -0.565250965 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system cGMP-PKG signaling pathway 0 -0.497035573 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Chemokine signaling pathway 0 -0.589920949 -0.483655084 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Collinsella 0 0 -0.405263721 kegg Genus NA 0.128 no no no no no no Phosphatidylinositol signaling system DNA replication 0 0.570158103 0.574517375 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Drug metabolism - other enzymes -0.566956522 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Eggerthella 0 0.494773936 0 kegg Genus NA 0.912 no no no no no no Phosphatidylinositol signaling system Endocrine resistance 0.513043478 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system ErbB signaling pathway 0.607826087 0 0.698069498 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Ether lipid metabolism 0.528695652 0.507905138 0.642213642 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Fanconi anemia pathway 0 0.685770751 0.731274131 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Fatty acid elongation -0.417391304 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Fatty acid metabolism -0.473913043 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system FoxO signaling pathway 0 0 0.423423423 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Fructose and mannose metabolism -0.742608696 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Galactose metabolism -0.636521739 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Glutathione metabolism 0 0 -0.532561133 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Glycerolipid metabolism 0 0 0.740540541 kegg kegg NA NA no no no no no up Phosphatidylinositol signaling system Glycerophospholipid metabolism 0 0.446640316 0.873873874 kegg kegg NA NA no no no no no up Phosphatidylinositol signaling system Glycolysis / Gluconeogenesis -0.672173913 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.458498024 0.546460746 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Glycosaminoglycan biosynthesis - keratan sulfate 0.544347826 0 0.54002574 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Glycosphingolipid biosynthesis - ganglio series 0 0.5 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Glycosphingolipid biosynthesis - lacto and neolacto series 0.536521739 0 0.487773488 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.436758893 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Glyoxylate and dicarboxylate metabolism 0 -0.416007905 -0.610810811 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Homologous recombination 0 0.56916996 0.62033462 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Inositol phosphate metabolism 0 0.62055336 0.832432432 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Linoleic acid metabolism -0.447826087 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Lysine degradation 0 0.596837945 0.87979408 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Mannose type O-glycan biosynthesis 0.553913043 0.483201581 0.858944659 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system MAPK signaling pathway 0 0 0.558558559 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Mismatch repair 0 0.473320158 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system mRNA surveillance pathway 0.764347826 0.449604743 0.857915058 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Mucin type O-glycan biosynthesis 0 0.490118577 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system N-Glycan biosynthesis 0.608695652 0.532608696 0.677992278 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Nicotinate and nicotinamide metabolism 0 0 -0.454568855 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Nitrogen metabolism -0.482608696 -0.446640316 -0.563449163 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Non-homologous end-joining -0.411304348 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Nucleotide excision repair 0 0.634387352 0.509395109 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system One carbon pool by folate 0 0.664031621 0.652767053 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Other glycan degradation -0.42 0 0.576833977 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Other types of O-glycan biosynthesis 0.545217391 0.682806324 0.923552124 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Oxidative phosphorylation 0.513913043 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Parabacteroides -0.450434783 0 0 kegg Genus NA 4.19E-05 no no no no up up Phosphatidylinositol signaling system Pentose and glucuronate interconversions 0 0.422924901 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Pentose phosphate pathway -0.67826087 -0.463438735 -0.647361647 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Phenylalanine metabolism -0.434782609 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Platinum drug resistance 0.472173913 0.698616601 0.62985843 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Porphyrin and chlorophyll metabolism 0 0 -0.429086229 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system PPAR signaling pathway -0.417391304 0 -0.534105534 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Protein export 0.68 0 0.600514801 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Pyrimidine metabolism -0.467826087 0.462450593 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Ras signaling pathway 0.56173913 0 0.772458172 yes kegg kegg NA NA no no no no up up Phosphatidylinositol signaling system Retinol metabolism -0.410434783 0.509881423 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Ribosome 0.523478261 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Ribosome biogenesis in eukaryotes 0.506086957 0.75 0.812870013 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system RNA degradation 0.792173913 0.41798419 0.828571429 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system RNA polymerase 0.506956522 0.651185771 0.57014157 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Selenocompound metabolism 0 0.701581028 0.740540541 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Spliceosome 0 0.592885375 0.767567568 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Starch and sucrose metabolism -0.686956522 0 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Steroid biosynthesis 0.459130435 0.485177866 0.422651223 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Steroid hormone biosynthesis 0 0 0.432432432 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Sulfur metabolism 0 0 -0.555212355 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Synthesis and degradation of ketone bodies 0 0.693675889 0.526383526 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Taurine and hypotaurine metabolism 0 0 0.501673102 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Terpenoid backbone biosynthesis 0 0.541501976 0.642471042 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Ubiquinone and other terpenoid-quinone biosynthesis 0 0.492094862 0.436293436 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system "Valine, leucine and isoleucine degradation" 0 0.442687747 0 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Various types of N-glycan biosynthesis 0.483478261 0.595849802 0.619047619 kegg kegg NA NA no no no no no no Phosphatidylinositol signaling system Viral protein interaction with cytokine and cytokine receptor 0 -0.4743083 -0.496010296 kegg kegg NA NA no no no no no no Phospholipase D signaling pathway 2-Oxocarboxylic acid metabolism 0 -0.612648221 -0.458172458 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway ABC transporters 0 0.423913043 0 kegg kegg NA NA no up up no up up Phospholipase D signaling pathway "Alanine, aspartate and glutamate metabolism" 0 0.641304348 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway alpha-Linolenic acid metabolism 0 0.495059289 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Amino sugar and nucleotide sugar metabolism -0.550434783 0 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Aminoacyl-tRNA biosynthesis -0.480869565 -0.471343874 -0.463835264 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Arachidonic acid metabolism -0.48 0 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Arginine and proline metabolism 0 0.644268775 0 kegg kegg NA NA no up up no up no Phospholipase D signaling pathway Arginine biosynthesis 0 0.632411067 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Ascorbate and aldarate metabolism 0 0 -0.438610039 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Bacteroides 0 -0.505928854 0 LPS-producing kegg Genus NA 0.000267 no up up dn dn up Phospholipase D signaling pathway Base excision repair -0.419130435 0 -0.453796654 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway beta-Alanine metabolism 0 -0.584980237 -0.583783784 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Biosynthesis of cofactors -0.44 -0.454545455 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Biosynthesis of unsaturated fatty acids -0.436521739 -0.516798419 -0.471814672 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Butanoate metabolism -0.482608696 -0.848814229 -0.786872587 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Butyricimonas 0.473657229 0 0 butyrate-producing kegg Genus NA 0.17 no up up no no no Phospholipase D signaling pathway Calcium signaling pathway 0 0 0.406692407 kegg kegg NA NA no up up no up up Phospholipase D signaling pathway cAMP signaling pathway 0 0.650197628 0.555984556 yes kegg kegg NA NA no up up no up up Phospholipase D signaling pathway Carbon metabolism 0 -0.438735178 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway cGMP-PKG signaling pathway 0 0.489130435 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Chemokine signaling pathway 0.58 0.523715415 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Citrate cycle (TCA cycle) -0.575652174 -0.877470356 -0.583011583 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Clostridium 0 -0.468650518 0 kegg Genus NA 0.925 no up up no no no Phospholipase D signaling pathway Cysteine and methionine metabolism -0.685217391 -0.941699605 -0.502702703 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Cytokine-cytokine receptor interaction 0.522608696 0 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway DNA replication -0.573913043 -0.725296443 -0.562934363 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Drug metabolism - cytochrome P450 -0.732173913 -0.79743083 -0.446074646 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Drug metabolism - other enzymes -0.548695652 -0.825098814 -0.457400257 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.744071146 -0.566280566 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Endocrine resistance 0.432173913 0 0.546718147 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway ErbB signaling pathway 0.500869565 0.589920949 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Ether lipid metabolism 0 0 -0.400772201 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Fanconi anemia pathway -0.543478261 0 -0.498584299 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Fatty acid biosynthesis 0 0.639328063 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Fatty acid elongation 0 -0.652173913 -0.572715573 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Folate biosynthesis -0.608695652 -0.466403162 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway FoxO signaling pathway 0 0.553359684 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Fructose and mannose metabolism 0 0.606719368 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Galactose metabolism 0 0.432806324 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Glutathione metabolism -0.500869565 -0.553359684 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Glycerolipid metabolism 0 0.559288538 0 kegg kegg NA NA no up up no no up Phospholipase D signaling pathway Glycerophospholipid metabolism 0 0.471343874 0 kegg kegg NA NA no up up no no up Phospholipase D signaling pathway Glycolysis / Gluconeogenesis -0.457391304 -0.901185771 -0.442471042 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.486086957 0.882411067 0.482625483 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0.457391304 0 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.433043478 0.518774704 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.596837945 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway HIF-1 signaling pathway 0 -0.811264822 -0.528442728 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Homologous recombination -0.468695652 0 -0.512226512 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Linoleic acid metabolism -0.580869565 0 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Metabolism of xenobiotics by cytochrome P450 -0.693913043 -0.794466403 -0.414414414 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Mismatch repair -0.619130435 -0.711462451 -0.618790219 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Mucin type O-glycan biosynthesis -0.573043478 0 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway N-Glycan biosynthesis 0 -0.657114625 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway NF-kappa B signaling pathway 0 0.785573123 0.416216216 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Nicotinate and nicotinamide metabolism 0 0.741106719 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Nitrogen metabolism 0 0.632411067 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Non-homologous end-joining -0.448695652 -0.776679842 -0.524581725 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Nucleotide excision repair -0.613913043 -0.614624506 -0.571943372 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Odoribacter -0.498314732 0 0 butyrate-producing kegg Genus NA 0.798 no up up no no no Phospholipase D signaling pathway One carbon pool by folate -0.50173913 -0.531620553 -0.440669241 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Other glycan degradation 0 0.437747036 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Oxidative phosphorylation 0 -0.536561265 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Pantothenate and CoA biosynthesis 0 0.532608696 0 kegg kegg NA NA no up up no no dn Phospholipase D signaling pathway Pentose and glucuronate interconversions -0.664347826 -0.808300395 -0.570656371 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Phenylalanine metabolism 0 -0.657114625 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway PPAR signaling pathway 0 0.486166008 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Prevotella 0 0.427898299 0.440922165 acetate-producing kegg Genus NA 0.287 no up up no no no Phospholipase D signaling pathway Primary bile acid biosynthesis -0.610434783 -0.713438735 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Propanoate metabolism -0.659130435 -0.944664032 -0.527155727 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Proteasome 0 -0.860671937 -0.517889318 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Protein export 0 -0.783596838 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Pyrimidine metabolism -0.51826087 -0.5 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Pyruvate metabolism -0.639130435 -0.93972332 -0.58970399 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Rap1 signaling pathway 0 0 0.422908623 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Ras signaling pathway 0 -0.533596838 0 yes kegg kegg NA NA no up up no up up Phospholipase D signaling pathway Retinol metabolism -0.464347826 -0.428853755 -0.451737452 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Ribosome 0 -0.703557312 -0.493178893 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Ribosome biogenesis in eukaryotes 0 -0.489130435 -0.405920206 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway RNA degradation 0 -0.636363636 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway RNA polymerase 0 -0.597826087 -0.468468468 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway RNA transport -0.524347826 -0.781620553 -0.468468468 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Sphingolipid signaling pathway 0.50173913 0 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Starch and sucrose metabolism 0 0.577075099 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Steroid biosynthesis 0 -0.652173913 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Steroid hormone biosynthesis -0.553043478 -0.557312253 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Succinivibrio 0 0 -0.411251532 kegg Genus NA 0.138 no up up no no no Phospholipase D signaling pathway Synthesis and degradation of ketone bodies -0.553043478 -0.631422925 -0.473101673 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Taurine and hypotaurine metabolism 0 0.639328063 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Terpenoid backbone biosynthesis 0 0 -0.43989704 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Thiamine metabolism -0.606086957 -0.789525692 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Tryptophan metabolism -0.511304348 -0.739130435 -0.615701416 kegg kegg NA NA no up up no up no Phospholipase D signaling pathway Tyrosine metabolism -0.479130435 -0.699604743 -0.526898327 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.640869565 -0.562252964 -0.483912484 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway "Valine, leucine and isoleucine degradation" -0.616521739 -0.696640316 -0.674903475 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Various types of N-glycan biosynthesis 0 -0.566205534 0 kegg kegg NA NA no up up no no no Phospholipase D signaling pathway Viral protein interaction with cytokine and cytokine receptor 0.446086957 0 0 kegg kegg NA NA no up up no no no Phototransduction ABC transporters -0.577391304 -0.675889328 0 kegg kegg NA NA no no no no up up Phototransduction Adherens junction 0 0.627470356 0 kegg kegg NA NA no no no no no no Phototransduction Adrenergic signaling in cardiomyocytes 0.523478261 0 0 kegg kegg NA NA no no no no no up Phototransduction "Alanine, aspartate and glutamate metabolism" -0.464347826 -0.520750988 -0.407464607 kegg kegg NA NA no no no no no no Phototransduction Antigen processing and presentation 0 0.581027668 0 kegg kegg NA NA no no no no no no Phototransduction Apelin signaling pathway 0 0.64229249 0.402574003 kegg kegg NA NA no no no no no no Phototransduction Apoptosis 0 -0.460474308 -0.401544402 kegg kegg NA NA no no no no no no Phototransduction Apoptosis - multiple species 0 -0.551383399 0 kegg kegg NA NA no no no no no no Phototransduction Arginine and proline metabolism 0 -0.468379447 0 kegg kegg NA NA no no no no up no Phototransduction Arginine biosynthesis -0.443478261 -0.460474308 -0.441956242 kegg kegg NA NA no no no no no no Phototransduction Autophagy - animal 0 -0.739130435 0 kegg kegg NA NA no no no no no no Phototransduction Autophagy - other 0 -0.530632411 0 kegg kegg NA NA no no no no no no Phototransduction B cell receptor signaling pathway -0.43826087 -0.54743083 -0.501673102 kegg kegg NA NA no no no no no no Phototransduction Basal transcription factors 0 0 0.442471042 kegg kegg NA NA no no no no no no Phototransduction Base excision repair 0 0 0.462290862 kegg kegg NA NA no no no no no no Phototransduction beta-Alanine metabolism 0 0.634387352 0 kegg kegg NA NA no no no no no no Phototransduction Biosynthesis of unsaturated fatty acids 0 0.603754941 0.571171171 kegg kegg NA NA no no no no no no Phototransduction Butanoate metabolism 0 0.628458498 0.542342342 kegg kegg NA NA no no no no no no Phototransduction C-type lectin receptor signaling pathway 0 -0.56027668 -0.488545689 kegg kegg NA NA no no no no no no Phototransduction cAMP signaling pathway 0 -0.454545455 0 yes kegg kegg NA NA no no no no up up Phototransduction Carbon metabolism 0 0.588932806 0 kegg kegg NA NA no no no no no no Phototransduction Cardiac muscle contraction 0 0.464426877 0 kegg kegg NA NA no no no no no up Phototransduction Cell cycle 0 0 0.556756757 kegg kegg NA NA no no no no no no Phototransduction Circadian entrainment 0.649565217 0.532608696 0 kegg kegg NA NA no no no no up up Phototransduction Citrate cycle (TCA cycle) 0 0.711462451 0.437065637 kegg kegg NA NA no no no no no no Phototransduction Cysteine and methionine metabolism 0.419130435 0.720355731 0.522522523 kegg kegg NA NA no no no no no no Phototransduction Cytosolic DNA-sensing pathway 0 -0.440711462 0 kegg kegg NA NA no no no no no no Phototransduction DNA replication 0 0.454545455 0.433462033 kegg kegg NA NA no no no no no no Phototransduction Dopaminergic synapse 0.469565217 0 0 kegg kegg NA NA no no no no up no Phototransduction Drug metabolism - cytochrome P450 0.447826087 0.624505929 0 kegg kegg NA NA no no no no no no Phototransduction Drug metabolism - other enzymes 0 0.719367589 0 kegg kegg NA NA no no no no no no Phototransduction EGFR tyrosine kinase inhibitor resistance 0 0.497035573 0 kegg kegg NA NA no no no no no no Phototransduction ErbB signaling pathway 0 -0.809288538 0 kegg kegg NA NA no no no no no no Phototransduction Fanconi anemia pathway 0 0 0.491634492 kegg kegg NA NA no no no no no no Phototransduction Fatty acid biosynthesis 0 -0.498023715 -0.476705277 kegg kegg NA NA no no no no no no Phototransduction Fatty acid elongation 0 0.707509881 0.516859717 kegg kegg NA NA no no no no no no Phototransduction Fc epsilon RI signaling pathway 0 -0.540513834 -0.515572716 kegg kegg NA NA no no no no no no Phototransduction Focal adhesion 0 0.718379447 0 kegg kegg NA NA no no no no up up Phototransduction FoxO signaling pathway 0 -0.665019763 0 kegg kegg NA NA no no no no no no Phototransduction Fructose and mannose metabolism -0.409565217 -0.730237154 0 kegg kegg NA NA no no no no no no Phototransduction Galactose metabolism -0.432173913 -0.427865613 0 kegg kegg NA NA no no no no no no Phototransduction Gap junction 0 -0.468379447 0 kegg kegg NA NA no no no no no no Phototransduction Glutamatergic synapse 0 -0.548418972 0 kegg kegg NA NA no no no no up up Phototransduction Glycerolipid metabolism -0.650434783 -0.747035573 0 kegg kegg NA NA no no no no no up Phototransduction Glycerophospholipid metabolism -0.432173913 -0.617588933 0 kegg kegg NA NA no no no no no up Phototransduction Glycolysis / Gluconeogenesis 0 0.813241107 0 kegg kegg NA NA no no no no no no Phototransduction Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.492173913 -0.87055336 0 kegg kegg NA NA no no no no no no Phototransduction Glycosphingolipid biosynthesis - lacto and neolacto series 0 -0.518774704 0 kegg kegg NA NA no no no no no no Phototransduction Glyoxylate and dicarboxylate metabolism -0.522608696 -0.43083004 -0.50965251 kegg kegg NA NA no no no no no no Phototransduction Hematopoietic cell lineage 0 0.633399209 0 kegg kegg NA NA no no no no no no Phototransduction HIF-1 signaling pathway 0 0.614624506 0 kegg kegg NA NA no no no no no no Phototransduction Hippo signaling pathway 0 0.595849802 0 kegg kegg NA NA no no no no no no Phototransduction Homologous recombination 0 0 0.487516088 kegg kegg NA NA no no no no no no Phototransduction IL-17 signaling pathway 0 0 -0.56036036 kegg kegg NA NA no no no no no no Phototransduction Inositol phosphate metabolism -0.451304348 -0.602766798 0 kegg kegg NA NA no no no no no no Phototransduction JAK-STAT signaling pathway 0 -0.82312253 0 kegg kegg NA NA no no no no no no Phototransduction Leukocyte transendothelial migration 0 0.56027668 0 kegg kegg NA NA no no no no no no Phototransduction Long-term potentiation 0.6 0.750988142 0.531531532 kegg kegg NA NA no no no no no up Phototransduction Longevity regulating pathway 0 -0.510869565 0 kegg kegg NA NA no no no no no no Phototransduction Lysine degradation 0 -0.469367589 0 kegg kegg NA NA no no no no no no Phototransduction Mannose type O-glycan biosynthesis 0 -0.473320158 0 kegg kegg NA NA no no no no no no Phototransduction Metabolism of xenobiotics by cytochrome P450 0.417391304 0.711462451 0 kegg kegg NA NA no no no no no no Phototransduction Mismatch repair 0 0.538537549 0.562934363 kegg kegg NA NA no no no no no no Phototransduction mTOR signaling pathway 0 0.496047431 0 kegg kegg NA NA no no no no no no Phototransduction Neurotrophin signaling pathway 0 -0.523715415 0 kegg kegg NA NA no no no no no no Phototransduction NF-kappa B signaling pathway -0.686956522 -0.777667984 -0.659202059 kegg kegg NA NA no no no no no no Phototransduction Nicotinate and nicotinamide metabolism 0 -0.468379447 -0.575289575 kegg kegg NA NA no no no no no no Phototransduction Nitrogen metabolism -0.470434783 -0.444664032 -0.422651223 kegg kegg NA NA no no no no no no Phototransduction NOD-like receptor signaling pathway 0 -0.505928854 0 kegg kegg NA NA no no no no no no Phototransduction Non-homologous end-joining 0 0.721343874 0 kegg kegg NA NA no no no no no no Phototransduction Notch signaling pathway 0 -0.711462451 0 kegg kegg NA NA no no no no no no Phototransduction Nucleotide excision repair 0 0 0.543886744 kegg kegg NA NA no no no no no no Phototransduction One carbon pool by folate 0 0 0.441956242 kegg kegg NA NA no no no no no no Phototransduction Oocyte meiosis 0.713043478 0.836956522 0.765765766 kegg kegg NA NA no no no no no no Phototransduction Osteoclast differentiation 0 0 -0.611583012 kegg kegg NA NA no no no no no no Phototransduction Other glycan degradation -0.52173913 -0.601778656 0 kegg kegg NA NA no no no no no no Phototransduction Other types of O-glycan biosynthesis 0 -0.483201581 0 kegg kegg NA NA no no no no no no Phototransduction Oxidative phosphorylation 0 0.549407115 0.421106821 kegg kegg NA NA no no no no no no Phototransduction p53 signaling pathway 0 -0.574110672 0 kegg kegg NA NA no no no no no no Phototransduction Pentose and glucuronate interconversions 0 0.609683794 0.562162162 kegg kegg NA NA no no no no no no Phototransduction Pentose phosphate pathway -0.42 0 -0.504761905 kegg kegg NA NA no no no no no no Phototransduction Peroxisome 0 0 -0.407979408 kegg kegg NA NA no no no no no no Phototransduction Phenylalanine metabolism 0 0.583003953 0 kegg kegg NA NA no no no no no no Phototransduction Phospholipase D signaling pathway 0 -0.788537549 -0.521492921 kegg kegg NA NA no no no no up up Phototransduction Platelet activation 0 0.580039526 0 kegg kegg NA NA no no no no no no Phototransduction Platinum drug resistance 0 -0.535573123 0 kegg kegg NA NA no no no no no no Phototransduction PPAR signaling pathway 0 0 -0.478507079 kegg kegg NA NA no no no no no no Phototransduction Primary bile acid biosynthesis 0 0.81027668 0 kegg kegg NA NA no no no no no no Phototransduction Propanoate metabolism 0 0.732213439 0.448648649 kegg kegg NA NA no no no no no no Phototransduction Proteasome 0 0.806324111 0 kegg kegg NA NA no no no no no no Phototransduction Protein export 0.424347826 0.675889328 0.465122265 kegg kegg NA NA no no no no no no Phototransduction Pyruvate metabolism 0 0.690711462 0 kegg kegg NA NA no no no no no no Phototransduction Ras signaling pathway 0.525217391 0.506916996 0.511969112 yes kegg kegg NA NA no no no no up up Phototransduction Retrograde endocannabinoid signaling 0 0.631422925 0.476190476 kegg kegg NA NA no no no no no up Phototransduction Ribosome 0 0.587944664 0 kegg kegg NA NA no no no no no no Phototransduction Ribosome biogenesis in eukaryotes 0 0 0.511969112 kegg kegg NA NA no no no no no no Phototransduction RIG-I-like receptor signaling pathway 0 -0.732213439 -0.555212355 kegg kegg NA NA no no no no no no Phototransduction RNA degradation 0 0 0.425482625 kegg kegg NA NA no no no no no no Phototransduction RNA transport 0 0.498023715 0 kegg kegg NA NA no no no no no no Phototransduction Signaling pathways regulating pluripotency of stem cells 0 -0.613636364 0 kegg kegg NA NA no no no no no no Phototransduction SNARE interactions in vesicular transport -0.465217391 -0.614624506 0 kegg kegg NA NA no no no no no no Phototransduction Spliceosome 0 -0.503952569 0 kegg kegg NA NA no no no no no no Phototransduction Steroid biosynthesis 0 0.64229249 0.538481338 kegg kegg NA NA no no no no no no Phototransduction Steroid hormone biosynthesis 0 0.533596838 0 kegg kegg NA NA no no no no no no Phototransduction Synthesis and degradation of ketone bodies 0 0.432806324 0.551351351 kegg kegg NA NA no no no no no no Phototransduction T cell receptor signaling pathway 0 -0.551383399 0 kegg kegg NA NA no no no no no no Phototransduction Taurine and hypotaurine metabolism 0 -0.836956522 0 kegg kegg NA NA no no no no no no Phototransduction Terpenoid backbone biosynthesis 0 0 0.499356499 kegg kegg NA NA no no no no no no Phototransduction TGF-beta signaling pathway 0.527826087 0.748023715 0.54980695 kegg kegg NA NA no no no no no no Phototransduction Thermogenesis 0 0.56916996 0.483655084 kegg kegg NA NA no no no no no no Phototransduction Thiamine metabolism 0 0.584980237 0 kegg kegg NA NA no no no no no no Phototransduction Tight junction 0 0.746047431 0 kegg kegg NA NA no no no no no no Phototransduction TNF signaling pathway 0 -0.757905138 -0.446074646 kegg kegg NA NA no no no no no no Phototransduction Toll-like receptor signaling pathway 0 -0.567193676 -0.546975547 yes kegg kegg NA NA no no no no no no Phototransduction Tryptophan metabolism 0 0.736166008 0 kegg kegg NA NA no no no no up no Phototransduction Tyrosine metabolism 0 0.58201581 0 kegg kegg NA NA no no no no no no Phototransduction Ubiquinone and other terpenoid-quinone biosynthesis 0 0.41798419 0 kegg kegg NA NA no no no no no no Phototransduction "Valine, leucine and isoleucine degradation" 0 0.543478261 0.540797941 kegg kegg NA NA no no no no no no Phototransduction Vascular smooth muscle contraction 0.551304348 0.625494071 0 kegg kegg NA NA no no no no no no Phototransduction VEGF signaling pathway 0 -0.662055336 0 kegg kegg NA NA no no no no no no PI3K-Akt signaling pathway ABC transporters 0.532173913 0 0 yes kegg kegg NA NA no up up no up up PI3K-Akt signaling pathway Aminoacyl-tRNA biosynthesis 0.423478261 0 0.411583012 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Anaerostipes 0 0.438717149 0 yes butyrate-producing kegg Genus NA 0.568 no up up no no no PI3K-Akt signaling pathway Arachidonic acid metabolism 0 0 -0.5001287 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Autophagy - animal 0.473913043 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Autophagy - other 0.589565217 0 0.426769627 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Basal transcription factors 0.446086957 0 0.611583012 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Base excision repair 0.555652174 0 0.614929215 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Butanoate metabolism 0 0 0.56962677 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Cell cycle 0.614782609 0 0.507078507 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Chemokine signaling pathway 0 0 -0.491119691 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Citrate cycle (TCA cycle) 0 0 0.526640927 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Cysteine and methionine metabolism 0.620869565 0 0.792020592 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway DNA replication 0.515652174 0 0.653281853 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway EGFR tyrosine kinase inhibitor resistance 0.594782609 0.601778656 0.902702703 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Fanconi anemia pathway 0.65826087 0 0.572972973 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Folate biosynthesis 0.54173913 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway FoxO signaling pathway 0.434782609 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Gemmiger 0 0.418397831 0 yes butyrate-producing kegg Genus NA 0.595 no up up no no no PI3K-Akt signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.599130435 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway HIF-1 signaling pathway 0.596521739 0.564229249 0.832947233 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Homologous recombination 0.685217391 0 0.578120978 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Inositol phosphate metabolism 0.446086957 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Lysine degradation 0.599130435 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Lysosome -0.453043478 0 -0.432689833 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway MAPK signaling pathway 0.52173913 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Mismatch repair 0 0 0.55958816 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway mRNA surveillance pathway 0 0 0.517374517 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway mTOR signaling pathway 0.611304348 0.59486166 0.857142857 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Mucin type O-glycan biosynthesis 0.5 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway N-Glycan biosynthesis 0 0 0.512483912 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Nitrogen metabolism 0 0 -0.416731017 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Non-homologous end-joining 0 0 0.433719434 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Nucleotide excision repair 0.491304348 0 0.642728443 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway One carbon pool by folate 0.479130435 0 0.424195624 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Oocyte meiosis 0 0 0.551866152 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Other glycan degradation 0.474782609 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Other types of O-glycan biosynthesis 0.556521739 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway p53 signaling pathway 0.474782609 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Parabacteroides 0 0 -0.504279556 yes kegg Genus NA 4.19E-05 no up up no up up PI3K-Akt signaling pathway Pentose and glucuronate interconversions 0 0 0.45997426 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Phagosome -0.507826087 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Phospholipase D signaling pathway -0.466086957 0 -0.538738739 yes kegg kegg NA NA no up up no up up PI3K-Akt signaling pathway Platinum drug resistance 0.443478261 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Propanoate metabolism 0.605217391 0.415019763 0.804375804 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Protein export 0 0 0.647104247 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Protein processing in endoplasmic reticulum 0 0 0.538996139 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Pyruvate metabolism 0.536521739 0 0.657400257 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Rap1 signaling pathway -0.434782609 -0.459486166 -0.424453024 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Retinol metabolism 0 0 0.40978121 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Ribosome 0 0 0.620849421 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Ribosome biogenesis in eukaryotes 0.563478261 0 0.613899614 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway RNA degradation 0 0 0.610810811 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway RNA polymerase 0.414782609 0 0.57966538 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway RNA transport 0.735652174 0.643280632 0.740797941 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Selenocompound metabolism 0.567826087 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway SNARE interactions in vesicular transport 0.513043478 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Sphingolipid metabolism -0.416521739 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Spliceosome 0.733913043 0 0.644272844 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Synthesis and degradation of ketone bodies 0.493043478 0 0.450707851 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Terpenoid backbone biosynthesis 0.423478261 0 0.44041184 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Thiamine metabolism 0.665217391 0 0 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Tryptophan metabolism 0 0 0.488030888 yes kegg kegg NA NA no up up no up no PI3K-Akt signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 0 0.498069498 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway "Valine, leucine and isoleucine degradation" 0 0 0.541570142 yes kegg kegg NA NA no up up no no no PI3K-Akt signaling pathway Various types of N-glycan biosynthesis 0.486956522 0 0.545173745 yes kegg kegg NA NA no up up no no no Platelet activation ABC transporters 0 -0.615612648 0 kegg kegg NA NA no no no no up up Platelet activation Adherens junction 0.922608696 0.936758893 0.86023166 kegg kegg NA NA no no no no no no Platelet activation "Alanine, aspartate and glutamate metabolism" 0 -0.543478261 0 kegg kegg NA NA no no no no no no Platelet activation Alistipes 0 -0.428926526 0 kegg Genus NA 0.0114 no no no no up no Platelet activation Apelin signaling pathway -0.434782609 0 0 kegg kegg NA NA no no no no no no Platelet activation Apoptosis 0.415652174 0 0.506306306 kegg kegg NA NA no no no no no no Platelet activation Apoptosis - multiple species -0.673043478 -0.666996047 0 kegg kegg NA NA no no no no no no Platelet activation Arginine and proline metabolism 0 -0.428853755 0 kegg kegg NA NA no no no no up no Platelet activation Arginine biosynthesis 0 -0.454545455 0 kegg kegg NA NA no no no no no no Platelet activation Autophagy - animal -0.742608696 -0.78458498 -0.482110682 kegg kegg NA NA no no no no no no Platelet activation Autophagy - other -0.843478261 -0.84486166 -0.556756757 kegg kegg NA NA no no no no no no Platelet activation Basal transcription factors -0.666956522 0 -0.508880309 kegg kegg NA NA no no no no no no Platelet activation Base excision repair -0.643478261 0 0 kegg kegg NA NA no no no no no no Platelet activation Butyricicoccus -0.446011794 0 0 butyrate-producing kegg Genus NA 0.852 no no no no no no Platelet activation Calcium signaling pathway 0 0.451581028 0 kegg kegg NA NA no no no no up up Platelet activation Carbon metabolism 0 0.43972332 0 kegg kegg NA NA no no no no no no Platelet activation Cardiac muscle contraction 0 0.541501976 0 kegg kegg NA NA no no no no no up Platelet activation Chemokine signaling pathway 0 0 0.5003861 kegg kegg NA NA no no no no no no Platelet activation Complement and coagulation cascades 0 0 0.506821107 kegg kegg NA NA no no no no no no Platelet activation Cytokine-cytokine receptor interaction 0 0 0.652767053 kegg kegg NA NA no no no no no no Platelet activation Drug metabolism - cytochrome P450 0 0.481225296 0 kegg kegg NA NA no no no no no no Platelet activation Drug metabolism - other enzymes 0 0.602766798 0 kegg kegg NA NA no no no no no no Platelet activation EGFR tyrosine kinase inhibitor resistance -0.535652174 0 -0.403088803 kegg kegg NA NA no no no no no no Platelet activation ErbB signaling pathway -0.455652174 -0.557312253 0 kegg kegg NA NA no no no no no no Platelet activation Fatty acid biosynthesis 0 -0.447628458 0 kegg kegg NA NA no no no no no no Platelet activation Fatty acid degradation 0 -0.498023715 0 kegg kegg NA NA no no no no no no Platelet activation Focal adhesion 0.907826087 0.913043478 0.8 kegg kegg NA NA no no no no up up Platelet activation FoxO signaling pathway -0.435652174 -0.717391304 0 kegg kegg NA NA no no no no no no Platelet activation Gap junction 0.562608696 0 0.600772201 kegg kegg NA NA no no no no no no Platelet activation Glycerolipid metabolism 0 -0.604743083 0 kegg kegg NA NA no no no no no up Platelet activation Glycerophospholipid metabolism -0.542608696 -0.609683794 -0.417503218 kegg kegg NA NA no no no no no up Platelet activation Glycolysis / Gluconeogenesis 0 0.476284585 0 kegg kegg NA NA no no no no no no Platelet activation Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.541501976 0 kegg kegg NA NA no no no no no no Platelet activation Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.480869565 0 0 kegg kegg NA NA no no no no no no Platelet activation Glycosphingolipid biosynthesis - globo and isoglobo series 0.44173913 0 0 kegg kegg NA NA no no no no no no Platelet activation Glyoxylate and dicarboxylate metabolism 0 -0.464426877 0 kegg kegg NA NA no no no no no no Platelet activation HIF-1 signaling pathway -0.591304348 0 0 kegg kegg NA NA no no no no no no Platelet activation Hippo signaling pathway 0.883478261 0.827075099 0.790990991 kegg kegg NA NA no no no no no no Platelet activation Hippo signaling pathway - multiple species 0 -0.433794466 0 kegg kegg NA NA no no no no no no Platelet activation Homologous recombination 0 -0.58201581 0 kegg kegg NA NA no no no no no no Platelet activation Inositol phosphate metabolism 0 -0.617588933 0 kegg kegg NA NA no no no no no no Platelet activation Lachnospira 0 0.597479633 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Platelet activation Longevity regulating pathway 0 -0.483201581 0 kegg kegg NA NA no no no no no no Platelet activation Lysine degradation -0.626956522 -0.458498024 -0.445817246 kegg kegg NA NA no no no no no no Platelet activation MAPK signaling pathway 0 -0.66798419 0 kegg kegg NA NA no no no no no no Platelet activation Metabolism of xenobiotics by cytochrome P450 0 0.542490119 0 kegg kegg NA NA no no no no no no Platelet activation mRNA surveillance pathway -0.442608696 0 0 kegg kegg NA NA no no no no no no Platelet activation mTOR signaling pathway -0.492173913 0 -0.467953668 kegg kegg NA NA no no no no no no Platelet activation Mucin type O-glycan biosynthesis 0 -0.658102767 -0.437323037 kegg kegg NA NA no no no no no no Platelet activation NF-kappa B signaling pathway -0.586086957 -0.661067194 -0.416731017 kegg kegg NA NA no no no no no no Platelet activation Nitrogen metabolism 0 -0.440711462 0 kegg kegg NA NA no no no no no no Platelet activation Oscillospira 0 -0.427865613 0 LPS-producing kegg Genus NA 0.62 no no no no no no Platelet activation Other glycan degradation 0 -0.52173913 0 kegg kegg NA NA no no no no no no Platelet activation Other types of O-glycan biosynthesis -0.593913043 -0.47826087 -0.446074646 kegg kegg NA NA no no no no no no Platelet activation Oxidative phosphorylation 0 0.564229249 0.415444015 kegg kegg NA NA no no no no no no Platelet activation p53 signaling pathway -0.75826087 -0.708498024 -0.559330759 kegg kegg NA NA no no no no no no Platelet activation Peroxisome 0 -0.466403162 0 kegg kegg NA NA no no no no no no Platelet activation Phagosome 0.406086957 0 0.461776062 kegg kegg NA NA no no no no no no Platelet activation Phenylalanine metabolism 0.613913043 0.540513834 0.428056628 kegg kegg NA NA no no no no no no Platelet activation PI3K-Akt signaling pathway -0.482608696 0 0 yes kegg kegg NA NA no no no no up up Platelet activation Platinum drug resistance -0.702608696 -0.645256917 0 kegg kegg NA NA no no no no no no Platelet activation PPAR signaling pathway 0 -0.466403162 0 kegg kegg NA NA no no no no no no Platelet activation Proteasome -0.520869565 0 0 kegg kegg NA NA no no no no no no Platelet activation Protein export -0.479130435 0 0 kegg kegg NA NA no no no no no no Platelet activation Pyrimidine metabolism 0 0 -0.522522523 kegg kegg NA NA no no no no no no Platelet activation Rap1 signaling pathway 0.896521739 0.933794466 0.953925354 kegg kegg NA NA no no no no no no Platelet activation Ras signaling pathway 0 0.501976285 0 yes kegg kegg NA NA no no no no up up Platelet activation Ribosome biogenesis in eukaryotes -0.567826087 0 -0.406692407 kegg kegg NA NA no no no no no no Platelet activation RNA degradation -0.42 0 -0.421879022 kegg kegg NA NA no no no no no no Platelet activation RNA polymerase -0.628695652 0 0 kegg kegg NA NA no no no no no no Platelet activation RNA transport -0.426086957 0 0 kegg kegg NA NA no no no no no no Platelet activation Selenocompound metabolism -0.705217391 -0.433794466 -0.44993565 kegg kegg NA NA no no no no no no Platelet activation Signaling pathways regulating pluripotency of stem cells 0 -0.502964427 0 kegg kegg NA NA no no no no no no Platelet activation SNARE interactions in vesicular transport -0.436521739 -0.683794466 0 kegg kegg NA NA no no no no no no Platelet activation Spliceosome -0.751304348 -0.718379447 -0.462805663 kegg kegg NA NA no no no no no no Platelet activation Taurine and hypotaurine metabolism -0.454782609 -0.59486166 0 kegg kegg NA NA no no no no no no Platelet activation TGF-beta signaling pathway 0 0.437747036 0 kegg kegg NA NA no no no no no no Platelet activation Thiamine metabolism 0 0 -0.448906049 kegg kegg NA NA no no no no no no Platelet activation Tight junction 0.800869565 0.882411067 0.638352638 kegg kegg NA NA no no no no no no Platelet activation Tyrosine metabolism 0 0.421936759 0 kegg kegg NA NA no no no no no no Platelet activation Various types of N-glycan biosynthesis -0.420869565 0 0 kegg kegg NA NA no no no no no no Platelet activation Vascular smooth muscle contraction 0 0.694664032 0 kegg kegg NA NA no no no no no no Platelet activation Viral protein interaction with cytokine and cytokine receptor 0 0 0.583783784 kegg kegg NA NA no no no no no no Platinum drug resistance Alistipes 0 0.442299524 0 kegg Genus NA 0.0114 no no no no up no Platinum drug resistance Amino sugar and nucleotide sugar metabolism 0 0.57312253 0 kegg kegg NA NA no no no no no no Platinum drug resistance Aminoacyl-tRNA biosynthesis 0.414782609 0.489130435 0.442728443 kegg kegg NA NA no no no no no no Platinum drug resistance Antifolate resistance 0 0.520750988 0 kegg kegg NA NA no no no no no no Platinum drug resistance Biosynthesis of amino acids 0 0 -0.403861004 kegg kegg NA NA no no no no no no Platinum drug resistance Carbon metabolism 0 -0.4743083 0 kegg kegg NA NA no no no no no no Platinum drug resistance Clostridium 0 -0.41872905 0 kegg Genus NA 0.925 no no no no no no Platinum drug resistance Cysteine and methionine metabolism 0 0 0.431917632 kegg kegg NA NA no no no no no no Platinum drug resistance Ether lipid metabolism 0 0 0.432175032 kegg kegg NA NA no no no no no no Platinum drug resistance Fructose and mannose metabolism 0 0.449604743 0 kegg kegg NA NA no no no no no no Platinum drug resistance Glycerolipid metabolism 0 0.786561265 0 kegg kegg NA NA no no no no no up Platinum drug resistance Glycerophospholipid metabolism 0.534782609 0.780632411 0.543629344 kegg kegg NA NA no no no no no up Platinum drug resistance Glycolysis / Gluconeogenesis 0 -0.43972332 0 kegg kegg NA NA no no no no no no Platinum drug resistance Glycosaminoglycan degradation -0.67826087 0 0 kegg kegg NA NA no no no no no up Platinum drug resistance Glycosphingolipid biosynthesis - ganglio series 0 0.469367589 0 kegg kegg NA NA no no no no no no Platinum drug resistance Glycosphingolipid biosynthesis - globo and isoglobo series -0.563478261 0 0 kegg kegg NA NA no no no no no no Platinum drug resistance Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.595652174 0.553359684 0 kegg kegg NA NA no no no no no no Platinum drug resistance Inositol phosphate metabolism 0.406956522 0.855731225 0.672586873 kegg kegg NA NA no no no no no no Platinum drug resistance Lachnospira 0 -0.478379061 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Platinum drug resistance Linoleic acid metabolism -0.49826087 0 0 kegg kegg NA NA no no no no no no Platinum drug resistance Lysine degradation 0.459130435 0.795454545 0.541570142 kegg kegg NA NA no no no no no no Platinum drug resistance Mannose type O-glycan biosynthesis 0 0.628458498 0.464864865 kegg kegg NA NA no no no no no no Platinum drug resistance Mucin type O-glycan biosynthesis 0 0.646245059 0.497812098 kegg kegg NA NA no no no no no no Platinum drug resistance N-Glycan biosynthesis 0.592173913 0 0.592020592 kegg kegg NA NA no no no no no no Platinum drug resistance One carbon pool by folate 0.515652174 0.431818182 0.466151866 kegg kegg NA NA no no no no no no Platinum drug resistance Oscillospira 0 0.549407115 0 LPS-producing kegg Genus NA 0.62 no no no no no no Platinum drug resistance Other glycan degradation 0 0.606719368 0 kegg kegg NA NA no no no no no no Platinum drug resistance Other types of O-glycan biosynthesis 0.523478261 0.837944664 0.734105534 kegg kegg NA NA no no no no no no Platinum drug resistance Pentose phosphate pathway -0.516521739 0 0 kegg kegg NA NA no no no no no no Platinum drug resistance Retinol metabolism 0 0 0.503474903 kegg kegg NA NA no no no no no no Platinum drug resistance Ruminococcus 0 -0.442299524 0 kegg Genus NA 0.0679 no no no no no dn Platinum drug resistance Selenocompound metabolism 0.727826087 0.849802372 0.732818533 kegg kegg NA NA no no no no no no Platinum drug resistance Slackia 0 0 0.480668965 kegg Genus NA 0.94 no no no no no no Platinum drug resistance Sphingolipid metabolism -0.590434783 0 0 kegg kegg NA NA no no no no no no Platinum drug resistance Steroid biosynthesis 0 0 0.482882883 kegg kegg NA NA no no no no no no Platinum drug resistance Synthesis and degradation of ketone bodies 0 0.434782609 0.456628057 kegg kegg NA NA no no no no no no Platinum drug resistance Taurine and hypotaurine metabolism 0.622608696 0.662055336 0 kegg kegg NA NA no no no no no no Platinum drug resistance Terpenoid backbone biosynthesis 0.529565217 0.511857708 0.45019305 kegg kegg NA NA no no no no no no Platinum drug resistance Ubiquinone and other terpenoid-quinone biosynthesis 0 0 0.426769627 kegg kegg NA NA no no no no no no Platinum drug resistance "Valine, leucine and isoleucine degradation" 0 0 0.409009009 kegg kegg NA NA no no no no no no Platinum drug resistance Various types of N-glycan biosynthesis 0.564347826 0 0.55032175 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism alpha-Linolenic acid metabolism 0 0 -0.436808237 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Arachidonic acid metabolism 0.505217391 0 0.700643501 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Ascorbate and aldarate metabolism 0 0 -0.477220077 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Butanoate metabolism 0.420869565 0 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Citrate cycle (TCA cycle) 0 0 -0.473616474 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Collinsella 0.523934054 0 0 kegg Genus NA 0.128 no no no no no no Porphyrin and chlorophyll metabolism Ether lipid metabolism 0 0.568181818 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Galactose metabolism 0 -0.466403162 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Glutathione metabolism 0.662608696 0.651185771 0.820849421 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Glycerolipid metabolism 0 0 -0.467696268 kegg kegg NA NA no no no no no up Porphyrin and chlorophyll metabolism Glycerophospholipid metabolism 0 0 -0.437065637 kegg kegg NA NA no no no no no up Porphyrin and chlorophyll metabolism "Glycine, serine and threonine metabolism" 0.935652174 0.942687747 0.98018018 kegg kegg NA NA no no no no up no Porphyrin and chlorophyll metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.548519949 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Glycosaminoglycan degradation 0 -0.583003953 -0.594337194 kegg kegg NA NA no no no no no up Porphyrin and chlorophyll metabolism Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0.617588933 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Lysine degradation 0 0 -0.436036036 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Nicotinate and nicotinamide metabolism 0 -0.436758893 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism One carbon pool by folate 0 0.416996047 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Other glycan degradation 0 0 -0.583011583 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Pantothenate and CoA biosynthesis -0.537391304 -0.437747036 0 kegg kegg NA NA no no no no no dn Porphyrin and chlorophyll metabolism Pentose and glucuronate interconversions 0 0 -0.474646075 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Pentose phosphate pathway 0 -0.540513834 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Purine metabolism 0.724347826 0.922924901 0.624710425 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Pyruvate metabolism 0 0.441699605 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Retinol metabolism 0 0 -0.434234234 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Sphingolipid metabolism 0 0 -0.453281853 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Starch and sucrose metabolism 0 -0.42687747 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Synthesis and degradation of ketone bodies 0 0.476284585 0 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Thiamine metabolism 0 0.578063241 0.404633205 kegg kegg NA NA no no no no no no Porphyrin and chlorophyll metabolism Various types of N-glycan biosynthesis 0 0 -0.522265122 kegg kegg NA NA no no no no no no Porphyromonas Prevotella 0.483549128 0 0 Genus Genus 0.999 0.367 no no no no no no PPAR signaling pathway 2-Oxocarboxylic acid metabolism 0 -0.576086957 0 kegg kegg NA NA no no no no no no PPAR signaling pathway ABC transporters 0 0 -0.412355212 kegg kegg NA NA no no no no up up PPAR signaling pathway "Alanine, aspartate and glutamate metabolism" 0.492173913 0.770750988 0.402831403 kegg kegg NA NA no no no no no no PPAR signaling pathway Aminoacyl-tRNA biosynthesis 0 -0.472332016 -0.649163449 kegg kegg NA NA no no no no no no PPAR signaling pathway Antifolate resistance 0 -0.571146245 -0.423938224 kegg kegg NA NA no no no no no no PPAR signaling pathway Arginine and proline metabolism 0.600869565 0.716403162 0.616473616 kegg kegg NA NA no no no no up no PPAR signaling pathway Arginine biosynthesis 0.515652174 0.781620553 0.509137709 kegg kegg NA NA no no no no no no PPAR signaling pathway Ascorbate and aldarate metabolism 0 -0.522727273 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Basal transcription factors 0 -0.529644269 -0.578120978 kegg kegg NA NA no no no no no no PPAR signaling pathway Biosynthesis of amino acids 0 0.811264822 0.624967825 kegg kegg NA NA no no no no no no PPAR signaling pathway Biosynthesis of cofactors -0.433043478 -0.568181818 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Butanoate metabolism 0 -0.621541502 -0.433462033 kegg kegg NA NA no no no no no no PPAR signaling pathway Carbon metabolism 0 0 0.431145431 kegg kegg NA NA no no no no no no PPAR signaling pathway Citrate cycle (TCA cycle) 0 -0.587944664 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Cysteine and methionine metabolism 0 -0.566205534 -0.546718147 kegg kegg NA NA no no no no no no PPAR signaling pathway DNA replication 0 -0.741106719 -0.531016731 kegg kegg NA NA no no no no no no PPAR signaling pathway Drug metabolism - cytochrome P450 0 -0.718379447 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Drug metabolism - other enzymes 0 -0.632411067 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Endocrine resistance -0.492173913 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Ether lipid metabolism -0.494782609 -0.577075099 -0.579150579 kegg kegg NA NA no no no no no no PPAR signaling pathway Fatty acid biosynthesis 0.569565217 0.765810277 0.486229086 kegg kegg NA NA no no no no no no PPAR signaling pathway Fatty acid degradation 0.430434783 0.618577075 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Fatty acid metabolism 0.431304348 0.57312253 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Folate biosynthesis 0 -0.424901186 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Galactose metabolism 0 0.43083004 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Glutathione metabolism 0 -0.601778656 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Glycerophospholipid metabolism 0 0 -0.538996139 kegg kegg NA NA no no no no no up PPAR signaling pathway "Glycine, serine and threonine metabolism" -0.43826087 -0.431818182 0 kegg kegg NA NA no no no no up no PPAR signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.499130435 0.59486166 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.501976285 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate -0.469565217 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Glycosaminoglycan degradation 0 0.43083004 0 kegg kegg NA NA no no no no no up PPAR signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 -0.42687747 -0.584041184 kegg kegg NA NA no no no no no no PPAR signaling pathway Glycosphingolipid biosynthesis - globo and isoglobo series 0.417391304 0 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 0 -0.40952381 kegg kegg NA NA no no no no no no PPAR signaling pathway Glyoxylate and dicarboxylate metabolism 0.496521739 0.822134387 0.551608752 kegg kegg NA NA no no no no no no PPAR signaling pathway Inositol phosphate metabolism 0 0 -0.586615187 kegg kegg NA NA no no no no no no PPAR signaling pathway Linoleic acid metabolism 0 -0.565217391 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Lysine degradation 0 0 -0.492664093 kegg kegg NA NA no no no no no no PPAR signaling pathway Mannose type O-glycan biosynthesis 0 0 -0.466924067 kegg kegg NA NA no no no no no no PPAR signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.664031621 0 kegg kegg NA NA no no no no no no PPAR signaling pathway mRNA surveillance pathway 0 -0.625494071 -0.492406692 kegg kegg NA NA no no no no no no PPAR signaling pathway N-Glycan biosynthesis -0.602608696 -0.761857708 -0.602574003 kegg kegg NA NA no no no no no no PPAR signaling pathway Nicotinate and nicotinamide metabolism 0.597391304 0.732213439 0.708622909 kegg kegg NA NA no no no no no no PPAR signaling pathway Nitrogen metabolism 0.566956522 0.736166008 0.54028314 kegg kegg NA NA no no no no no no PPAR signaling pathway One carbon pool by folate 0 -0.780632411 -0.726383526 kegg kegg NA NA no no no no no no PPAR signaling pathway Other types of O-glycan biosynthesis 0 0 -0.61003861 kegg kegg NA NA no no no no no no PPAR signaling pathway Oxidative phosphorylation 0 -0.597826087 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Pantothenate and CoA biosynthesis 0.447826087 0.595849802 0.496782497 kegg kegg NA NA no no no no no dn PPAR signaling pathway Paraprevotella 0 -0.553626714 0 kegg Genus NA 0.118 no no no no no no PPAR signaling pathway Pentose and glucuronate interconversions 0 -0.708498024 -0.416473616 kegg kegg NA NA no no no no no no PPAR signaling pathway Pentose phosphate pathway 0 0.68083004 0.611068211 kegg kegg NA NA no no no no no no PPAR signaling pathway Phenylalanine metabolism 0 -0.595849802 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Platinum drug resistance 0 0 -0.581724582 kegg kegg NA NA no no no no no no PPAR signaling pathway Propanoate metabolism 0 -0.493083004 -0.446074646 kegg kegg NA NA no no no no no no PPAR signaling pathway Protein export 0 -0.589920949 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Purine metabolism 0 -0.464426877 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Pyrimidine metabolism 0 -0.757905138 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Pyruvate metabolism 0 -0.608695652 -0.488288288 kegg kegg NA NA no no no no no no PPAR signaling pathway Retinol metabolism 0 -0.60770751 -0.473359073 kegg kegg NA NA no no no no no no PPAR signaling pathway Ribosome 0 -0.488142292 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Ribosome biogenesis in eukaryotes 0 -0.630434783 -0.671299871 kegg kegg NA NA no no no no no no PPAR signaling pathway RNA degradation 0 -0.7243083 -0.473359073 kegg kegg NA NA no no no no no no PPAR signaling pathway RNA polymerase 0 -0.735177866 -0.618018018 kegg kegg NA NA no no no no no no PPAR signaling pathway Selenocompound metabolism 0 0 -0.626512227 kegg kegg NA NA no no no no no no PPAR signaling pathway Slackia 0 0 -0.417321675 kegg Genus NA 0.94 no no no no no no PPAR signaling pathway Spliceosome 0 0 -0.461776062 kegg kegg NA NA no no no no no no PPAR signaling pathway Starch and sucrose metabolism 0 0.650197628 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Steroid biosynthesis -0.509565217 -0.528656126 -0.619305019 kegg kegg NA NA no no no no no no PPAR signaling pathway Steroid hormone biosynthesis 0 -0.559288538 0 kegg kegg NA NA no no no no no no PPAR signaling pathway Synthesis and degradation of ketone bodies 0 -0.545454545 -0.557014157 kegg kegg NA NA no no no no no no PPAR signaling pathway Terpenoid backbone biosynthesis 0 0 -0.433976834 kegg kegg NA NA no no no no no no PPAR signaling pathway Tryptophan metabolism 0 -0.436758893 0 kegg kegg NA NA no no no no up no PPAR signaling pathway Tyrosine metabolism 0 -0.688735178 -0.402574003 kegg kegg NA NA no no no no no no PPAR signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.609683794 -0.581724582 kegg kegg NA NA no no no no no no PPAR signaling pathway "Valine, leucine and isoleucine degradation" 0 -0.644268775 -0.546718147 kegg kegg NA NA no no no no no no PPAR signaling pathway Various types of N-glycan biosynthesis 0 -0.563241107 -0.433204633 kegg kegg NA NA no no no no no no Prevotella Butyricimonas 0.432886335 0 0 acetate-producing butyrate-producing Genus Genus 0.287 0.17 no no no no no no Primary bile acid biosynthesis Ascorbate and aldarate metabolism 0.656521739 0 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Citrate cycle (TCA cycle) 0.862608696 0.751976285 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Fatty acid degradation 0.431304348 0 0.524581725 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Fatty acid elongation 0.785217391 0.805335968 0.765508366 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Fructose and mannose metabolism 0.439130435 -0.481225296 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Galactose metabolism 0.52 0 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Glycolysis / Gluconeogenesis 0.639130435 0.734189723 0.651737452 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Pentose and glucuronate interconversions 0.780869565 0.549407115 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Steroid biosynthesis 0 0.79743083 0 kegg kegg NA NA no no no no no no Primary bile acid biosynthesis Synthesis and degradation of ketone bodies 0.82173913 0.623517787 0.404375804 kegg kegg NA NA no no no no no no Primary immunodeficiency 2-Oxocarboxylic acid metabolism 0 0.5 0.46048906 kegg kegg NA NA no no no no no no Primary immunodeficiency ABC transporters 0.435652174 0.422924901 0 kegg kegg NA NA no no no no up up Primary immunodeficiency Acute myeloid leukemia 0 -0.649209486 -0.466151866 kegg kegg NA NA no no no no no no Primary immunodeficiency Adipocytokine signaling pathway -0.72173913 0 -0.418532819 kegg kegg NA NA no no no no no no Primary immunodeficiency Aldosterone-regulated sodium reabsorption 0 -0.505928854 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Alistipes -0.414851117 0 0 kegg Genus NA 0.0114 no no no no up no Primary immunodeficiency Allograft rejection 0 -0.526679842 0 kegg kegg NA NA no no no no no no Primary immunodeficiency alpha-Linolenic acid metabolism 0.420869565 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Amino sugar and nucleotide sugar metabolism 0.663478261 0.574110672 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Aminoacyl-tRNA biosynthesis 0.656521739 0.776679842 0.577348777 kegg kegg NA NA no no no no no no Primary immunodeficiency Amoebiasis 0 -0.545454545 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Amyotrophic lateral sclerosis -0.451304348 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Antifolate resistance 0 0.563241107 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Apoptosis 0 -0.621541502 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Apoptosis - multiple species 0 0.53458498 0.452767053 kegg kegg NA NA no no no no no no Primary immunodeficiency Arginine and proline metabolism 0 0 -0.431660232 kegg kegg NA NA no no no no up no Primary immunodeficiency Autoimmune thyroid disease 0 -0.526679842 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Axon guidance 0 -0.464426877 0 kegg kegg NA NA no no no no up up Primary immunodeficiency B cell receptor signaling pathway -0.527826087 -0.562252964 -0.841184041 kegg kegg NA NA no no no no no no Primary immunodeficiency Basal transcription factors 0 0.651185771 0.468725869 kegg kegg NA NA no no no no no no Primary immunodeficiency Base excision repair 0 0.785573123 0.679021879 kegg kegg NA NA no no no no no no Primary immunodeficiency beta-Alanine metabolism 0.504347826 0.423913043 0.643243243 kegg kegg NA NA no no no no no no Primary immunodeficiency Biosynthesis of cofactors 0 0.602766798 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Biosynthesis of unsaturated fatty acids 0.647826087 0.543478261 0.698069498 kegg kegg NA NA no no no no no no Primary immunodeficiency Bladder cancer 0 -0.475296443 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Butanoate metabolism 0.523478261 0.622529644 0.675160875 kegg kegg NA NA no no no no no no Primary immunodeficiency C-type lectin receptor signaling pathway 0 -0.52173913 -0.674646075 kegg kegg NA NA no no no no no no Primary immunodeficiency Calcium signaling pathway -0.495652174 0 0 kegg kegg NA NA no no no no up up Primary immunodeficiency cAMP signaling pathway -0.459130435 -0.726284585 -0.616473616 yes kegg kegg NA NA no no no no up up Primary immunodeficiency Carbon metabolism 0.446086957 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Cell cycle 0.536521739 0.710474308 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Cellular senescence 0 -0.541501976 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Central carbon metabolism in cancer 0.593043478 0 0.499356499 kegg kegg NA NA no no no no no no Primary immunodeficiency cGMP-PKG signaling pathway 0 -0.462450593 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Chagas disease 0 -0.527667984 -0.444015444 kegg kegg NA NA no no no no no no Primary immunodeficiency Chemical carcinogenesis - DNA adducts 0.61826087 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Chemokine signaling pathway 0 -0.575098814 -0.424195624 kegg kegg NA NA no no no no no no Primary immunodeficiency Cholesterol metabolism -0.512173913 -0.484189723 -0.45045045 yes kegg kegg NA NA no no no no no up Primary immunodeficiency Chronic myeloid leukemia -0.493913043 -0.529644269 -0.651222651 kegg kegg NA NA no no no no no no Primary immunodeficiency Citrate cycle (TCA cycle) 0.610434783 0.615612648 0.562162162 kegg kegg NA NA no no no no no no Primary immunodeficiency Cocaine addiction -0.490434783 0 -0.456370656 kegg kegg NA NA no no no no no no Primary immunodeficiency Colorectal cancer -0.409565217 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Coprococcus 0.435652174 0 0 butyrate-producing kegg Genus NA 0.612 no no no no no no Primary immunodeficiency Cysteine and methionine metabolism 0.813043478 0.579051383 0.743886744 kegg kegg NA NA no no no no no no Primary immunodeficiency Cytosolic DNA-sensing pathway 0 -0.531620553 -0.53024453 kegg kegg NA NA no no no no no no Primary immunodeficiency DNA replication 0.59826087 0.751976285 0.568854569 kegg kegg NA NA no no no no no no Primary immunodeficiency Drug metabolism - cytochrome P450 0.467826087 0.502964427 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Drug metabolism - other enzymes 0.530434783 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Endocytosis 0 -0.432806324 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Endometrial cancer 0 -0.517786561 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Epithelial cell signaling in Helicobacter pylori infection 0 -0.567193676 -0.637580438 kegg kegg NA NA no no no no no no Primary immunodeficiency Estrogen signaling pathway 0.669565217 0.598814229 0.535907336 kegg kegg NA NA no no no no no no Primary immunodeficiency Ether lipid metabolism -0.432173913 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Fanconi anemia pathway 0.650434783 0.846837945 0.643500644 kegg kegg NA NA no no no no no no Primary immunodeficiency Fatty acid degradation 0.573043478 0 0.41003861 kegg kegg NA NA no no no no no no Primary immunodeficiency Fatty acid elongation 0.494782609 0 0.688545689 kegg kegg NA NA no no no no no no Primary immunodeficiency Fatty acid metabolism 0.546956522 0 0.423680824 kegg kegg NA NA no no no no no no Primary immunodeficiency Fc epsilon RI signaling pathway -0.457391304 -0.489130435 -0.448391248 kegg kegg NA NA no no no no no no Primary immunodeficiency Fc gamma R-mediated phagocytosis 0.422608696 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Ferroptosis -0.424347826 -0.590909091 0 kegg kegg NA NA no no no no no no Primary immunodeficiency FoxO signaling pathway 0.51826087 0 0.661261261 kegg kegg NA NA no no no no no no Primary immunodeficiency "Glycine, serine and threonine metabolism" 0 0.440711462 0 kegg kegg NA NA no no no no up no Primary immunodeficiency Glycolysis / Gluconeogenesis 0.650434783 0 0.430888031 kegg kegg NA NA no no no no no no Primary immunodeficiency Glycosaminoglycan biosynthesis - keratan sulfate -0.623478261 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Glycosphingolipid biosynthesis - ganglio series 0 0.576086957 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Glycosphingolipid biosynthesis - lacto and neolacto series -0.663478261 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.473043478 0.564229249 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Graft-versus-host disease 0 -0.526679842 0 kegg kegg NA NA no no no no no no Primary immunodeficiency "Growth hormone synthesis, secretion and action" 0 0 -0.410810811 kegg kegg NA NA no no no no no no Primary immunodeficiency Hedgehog signaling pathway 0 0.721343874 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Hematopoietic cell lineage 0 0 0.513770914 kegg kegg NA NA no no no no no no Primary immunodeficiency Hepatitis B 0 0 -0.517374517 kegg kegg NA NA no no no no no no Primary immunodeficiency Histidine metabolism 0 0 0.418018018 kegg kegg NA NA no no no no no no Primary immunodeficiency Homologous recombination 0.74173913 0.748023715 0.65997426 kegg kegg NA NA no no no no no no Primary immunodeficiency Human cytomegalovirus infection 0 -0.434782609 0 kegg kegg NA NA no no no no no dn Primary immunodeficiency Human papillomavirus infection 0 -0.530632411 -0.405662806 kegg kegg NA NA no no no no no no Primary immunodeficiency Huntington disease -0.473913043 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency IL-17 signaling pathway 0 -0.544466403 -0.433976834 kegg kegg NA NA no no no no no no Primary immunodeficiency Influenza A 0 -0.54743083 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Inositol phosphate metabolism 0 0.492094862 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Insulin resistance 0 0 -0.441698842 kegg kegg NA NA no no no no no no Primary immunodeficiency Insulin secretion -0.428695652 0 0 yes kegg kegg NA NA no no no no up up Primary immunodeficiency Intestinal immune network for IgA production -0.440869565 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency JAK-STAT signaling pathway 0.432173913 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Kaposi sarcoma-associated herpesvirus infection -0.673043478 -0.480237154 0 kegg kegg NA NA no no no no no dn Primary immunodeficiency Legionellosis 0.579130435 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Leishmaniasis 0.466956522 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Leukocyte transendothelial migration 0 -0.456521739 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Long-term depression -0.534782609 -0.600790514 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Long-term potentiation 0 0.502964427 0 kegg kegg NA NA no no no no no up Primary immunodeficiency Longevity regulating pathway -0.476521739 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Longevity regulating pathway - multiple species 0.790434783 0.446640316 0.785585586 kegg kegg NA NA no no no no no no Primary immunodeficiency Lysine degradation 0 0.427865613 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Lysosome 0 -0.570158103 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Mannose type O-glycan biosynthesis -0.585217391 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency MAPK signaling pathway 0.529565217 0.566205534 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Maturity onset diabetes of the young -0.552173913 0 0 kegg kegg NA NA no no no no up no Primary immunodeficiency Melanoma 0 -0.425889328 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Metabolism of xenobiotics by cytochrome P450 0.493043478 0.461462451 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Mineral absorption -0.485217391 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Mismatch repair 0.666956522 0.806324111 0.675160875 kegg kegg NA NA no no no no no no Primary immunodeficiency Mitophagy - animal -0.545217391 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Mucin type O-glycan biosynthesis 0.770434783 0.4743083 0.481853282 kegg kegg NA NA no no no no no no Primary immunodeficiency N-Glycan biosynthesis 0 0.458498024 0.562676963 kegg kegg NA NA no no no no no no Primary immunodeficiency Natural killer cell mediated cytotoxicity 0 -0.485177866 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Necroptosis 0 -0.443675889 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Neuroactive ligand-receptor interaction 0.42 0 0 kegg kegg NA NA no no no up up up Primary immunodeficiency Neurotrophin signaling pathway -0.46173913 -0.601778656 -0.701415701 kegg kegg NA NA no no no no no no Primary immunodeficiency NF-kappa B signaling pathway 0 0 -0.456370656 kegg kegg NA NA no no no no no no Primary immunodeficiency Nicotine addiction -0.406956522 0.440711462 -0.607979408 kegg kegg NA NA no no no no up up Primary immunodeficiency Non-alcoholic fatty liver disease -0.442608696 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Non-homologous end-joining 0.64 0.537549407 0.739253539 kegg kegg NA NA no no no no no no Primary immunodeficiency Notch signaling pathway -0.495652174 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Nucleotide excision repair 0.632173913 0.838932806 0.729214929 kegg kegg NA NA no no no no no no Primary immunodeficiency One carbon pool by folate 0.660869565 0.732213439 0.531016731 kegg kegg NA NA no no no no no no Primary immunodeficiency Oocyte meiosis 0 0.441699605 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Osteoclast differentiation 0 0 -0.518918919 kegg kegg NA NA no no no no no no Primary immunodeficiency Other types of O-glycan biosynthesis 0 0.484189723 0 kegg kegg NA NA no no no no no no Primary immunodeficiency p53 signaling pathway 0 0.432806324 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Pancreatic secretion -0.494782609 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Parkinson disease -0.554782609 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Pathogenic Escherichia coli infection 0 -0.444664032 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Pathways of neurodegeneration - multiple diseases -0.577391304 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Pentose and glucuronate interconversions 0.568695652 0.54743083 0.44993565 kegg kegg NA NA no no no no no no Primary immunodeficiency Pentose phosphate pathway 0 -0.43972332 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Peroxisome 0.46173913 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Phagosome 0 -0.479249012 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Phenylalanine metabolism 0 0.566205534 0.459202059 kegg kegg NA NA no no no no no no Primary immunodeficiency Phosphatidylinositol signaling system 0 0.663043478 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Phospholipase D signaling pathway -0.429565217 0 -0.435521236 kegg kegg NA NA no no no no up up Primary immunodeficiency PI3K-Akt signaling pathway 0.53826087 0 0.453024453 yes kegg kegg NA NA no no no no up up Primary immunodeficiency Platinum drug resistance 0 0.563241107 0.524581725 kegg kegg NA NA no no no no no no Primary immunodeficiency PPAR signaling pathway 0 0 -0.481081081 kegg kegg NA NA no no no no no no Primary immunodeficiency Primary bile acid biosynthesis 0.683478261 0.438735178 0.498841699 kegg kegg NA NA no no no no no no Primary immunodeficiency Progesterone-mediated oocyte maturation 0 0.641304348 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Prolactin signaling pathway 0 -0.443675889 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Propanoate metabolism 0.863478261 0.542490119 0.692149292 kegg kegg NA NA no no no no no no Primary immunodeficiency Prostate cancer 0 -0.535573123 -0.607979408 kegg kegg NA NA no no no no no no Primary immunodeficiency Proximal tubule bicarbonate reclamation 0.494782609 0.502964427 0.465122265 kegg kegg NA NA no no no no no no Primary immunodeficiency Pyrimidine metabolism 0.59826087 0.548418972 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Pyruvate metabolism 0.81826087 0.539525692 0.683397683 kegg kegg NA NA no no no no no no Primary immunodeficiency Rap1 signaling pathway 0 -0.443675889 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Relaxin signaling pathway -0.604347826 -0.670948617 -0.774774775 kegg kegg NA NA no no no no no no Primary immunodeficiency Renin-angiotensin system 0 -0.460474308 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Retinol metabolism 0.80173913 0.802371542 0.625225225 kegg kegg NA NA no no no no no no Primary immunodeficiency Ribosome biogenesis in eukaryotes 0 0.77173913 0.509395109 kegg kegg NA NA no no no no no no Primary immunodeficiency RIG-I-like receptor signaling pathway 0 0 -0.538481338 kegg kegg NA NA no no no no no no Primary immunodeficiency RNA polymerase 0 0.650197628 0.482368082 kegg kegg NA NA no no no no no no Primary immunodeficiency RNA transport 0.545217391 0 0.423938224 kegg kegg NA NA no no no no no no Primary immunodeficiency Salmonella infection 0.493043478 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Selenocompound metabolism 0 0.741106719 0.498841699 kegg kegg NA NA no no no no no no Primary immunodeficiency Shigellosis -0.513913043 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Slackia 0 0 0.437866742 kegg Genus NA 0.94 no no no no no no Primary immunodeficiency Small cell lung cancer 0 0 -0.497039897 kegg kegg NA NA no no no no no up Primary immunodeficiency Sphingolipid metabolism -0.464347826 -0.455533597 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Sphingolipid signaling pathway 0 -0.586956522 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Spinocerebellar ataxia 0 0.528656126 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Spliceosome 0 0.566205534 0.414929215 kegg kegg NA NA no no no no no no Primary immunodeficiency Steroid biosynthesis 0 0.635375494 0.64015444 kegg kegg NA NA no no no no no no Primary immunodeficiency Steroid hormone biosynthesis 0.556521739 0.563241107 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Synthesis and degradation of ketone bodies 0.774782609 0.867588933 0.684942085 kegg kegg NA NA no no no no no no Primary immunodeficiency Systemic lupus erythematosus 0 -0.435770751 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Taste transduction 0.691304348 0.849802372 0 kegg kegg NA NA no no no no no up Primary immunodeficiency Terpenoid backbone biosynthesis 0.425217391 0.647233202 0.435263835 kegg kegg NA NA no no no no no no Primary immunodeficiency Th1 and Th2 cell differentiation -0.62 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Th17 cell differentiation -0.488695652 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Thermogenesis -0.431304348 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Thiamine metabolism 0.5 0.450592885 0 kegg kegg NA NA no no no no no no Primary immunodeficiency TNF signaling pathway 0 -0.472332016 -0.716344916 kegg kegg NA NA no no no no no no Primary immunodeficiency Toll-like receptor signaling pathway 0 -0.532608696 -0.67953668 yes kegg kegg NA NA no no no no no no Primary immunodeficiency Tryptophan metabolism 0.571304348 0.542490119 0.561647362 kegg kegg NA NA no no no no up no Primary immunodeficiency Type I diabetes mellitus 0 -0.516798419 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Tyrosine metabolism 0.600869565 0.634387352 0.741312741 kegg kegg NA NA no no no no no no Primary immunodeficiency Ubiquinone and other terpenoid-quinone biosynthesis 0.626956522 0.825098814 0.559330759 kegg kegg NA NA no no no no no no Primary immunodeficiency Ubiquitin mediated proteolysis -0.529565217 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency "Valine, leucine and isoleucine degradation" 0.66173913 0.704545455 0.757014157 kegg kegg NA NA no no no no no no Primary immunodeficiency Various types of N-glycan biosynthesis 0 0.456521739 0.583268983 kegg kegg NA NA no no no no no no Primary immunodeficiency VEGF signaling pathway 0 -0.418972332 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Viral carcinogenesis 0 -0.564229249 -0.528957529 kegg kegg NA NA no no no no no no Primary immunodeficiency Wnt signaling pathway -0.428695652 0 0 kegg kegg NA NA no no no no no no Primary immunodeficiency Yersinia infection 0 -0.432806324 0 kegg kegg NA NA no no no no no no Prion disease 2-Oxocarboxylic acid metabolism -0.460869565 0.424901186 0 kegg kegg NA NA no no no no no no Prion disease ABC transporters -0.42 -0.476284585 0 kegg kegg NA NA no no no no up up Prion disease Adherens junction 0 0.695652174 0.644272844 kegg kegg NA NA no no no no no no Prion disease Adrenergic signaling in cardiomyocytes 0.71826087 0.792490119 0 kegg kegg NA NA no no no no no up Prion disease AGE-RAGE signaling pathway in diabetic complications 0 -0.848814229 -0.431145431 kegg kegg NA NA no no no no no no Prion disease "Alanine, aspartate and glutamate metabolism" -0.57826087 -0.809288538 -0.542857143 kegg kegg NA NA no no no no no no Prion disease Aldosterone synthesis and secretion 0.530434783 0.700592885 0 kegg kegg NA NA no no no no up up Prion disease alpha-Linolenic acid metabolism -0.539130435 -0.770750988 0 kegg kegg NA NA no no no no no no Prion disease Alzheimer disease 0.95826087 0.976284585 0.932818533 kegg kegg NA NA no no no no no no Prion disease Amino sugar and nucleotide sugar metabolism -0.51826087 0 0 kegg kegg NA NA no no no no no no Prion disease Aminoacyl-tRNA biosynthesis -0.551304348 0 0 kegg kegg NA NA no no no no no no Prion disease Amyotrophic lateral sclerosis 0.946956522 0.953557312 0.915315315 kegg kegg NA NA no no no no no no Prion disease Apelin signaling pathway 0 0.833003953 0 kegg kegg NA NA no no no no no no Prion disease Apoptosis 0 -0.621541502 0 kegg kegg NA NA no no no no no no Prion disease Apoptosis - multiple species 0 -0.481225296 0 kegg kegg NA NA no no no no no no Prion disease Arginine and proline metabolism 0 -0.788537549 -0.594337194 kegg kegg NA NA no no no no up no Prion disease Arginine biosynthesis -0.580869565 -0.749011858 -0.494723295 kegg kegg NA NA no no no no no no Prion disease Autophagy - animal 0 -0.769762846 -0.526898327 kegg kegg NA NA no no no no no no Prion disease Axon guidance 0.489565217 0 0 kegg kegg NA NA no no no no up up Prion disease B cell receptor signaling pathway 0 -0.646245059 0 kegg kegg NA NA no no no no no no Prion disease beta-Alanine metabolism -0.649565217 0 0 kegg kegg NA NA no no no no no no Prion disease Bile secretion 0.440869565 0 0 kegg kegg NA NA no no no no no no Prion disease Biosynthesis of amino acids -0.710434783 -0.613636364 0 kegg kegg NA NA no no no no no no Prion disease Butanoate metabolism -0.512173913 0.492094862 0 kegg kegg NA NA no no no no no no Prion disease Butyricimonas 0.425194231 0 -0.420211079 butyrate-producing kegg Genus NA 0.17 no no no no no no Prion disease C-type lectin receptor signaling pathway 0 -0.646245059 -0.432432432 kegg kegg NA NA no no no no no no Prion disease Calcium signaling pathway 0.639130435 0.654150198 0 kegg kegg NA NA no no no no up up Prion disease cAMP signaling pathway 0.731304348 0 0 yes kegg kegg NA NA no no no no up up Prion disease Carbohydrate digestion and absorption 0 -0.533596838 0 kegg kegg NA NA no no no no no no Prion disease Carbon metabolism -0.636521739 0 0 kegg kegg NA NA no no no no no no Prion disease Cardiac muscle contraction 0.956521739 0.948616601 0.935907336 kegg kegg NA NA no no no no no up Prion disease Cell adhesion molecules -0.504347826 0 0 kegg kegg NA NA no no no no no no Prion disease Cell cycle 0 0.41798419 0 kegg kegg NA NA no no no no no no Prion disease Cellular senescence 0 -0.434782609 0 kegg kegg NA NA no no no no no no Prion disease cGMP-PKG signaling pathway 0 -0.633399209 0 kegg kegg NA NA no no no no no no Prion disease Chemokine signaling pathway 0 -0.473320158 0 kegg kegg NA NA no no no no no no Prion disease Circadian entrainment 0.43826087 0.562252964 0 kegg kegg NA NA no no no no up up Prion disease Circadian rhythm 0.564347826 0 0 kegg kegg NA NA no no no no no no Prion disease Citrate cycle (TCA cycle) 0 0.539525692 0 kegg kegg NA NA no no no no no no Prion disease Complement and coagulation cascades -0.505217391 -0.637351779 0 kegg kegg NA NA no no no no no no Prion disease Cysteine and methionine metabolism 0 0.598814229 0 kegg kegg NA NA no no no no no no Prion disease DNA replication 0 0.515810277 0 kegg kegg NA NA no no no no no no Prion disease Dopaminergic synapse 0.660869565 0.682806324 0 kegg kegg NA NA no no no no up no Prion disease Drug metabolism - cytochrome P450 0 0.58201581 0 kegg kegg NA NA no no no no no no Prion disease Drug metabolism - other enzymes -0.463478261 0.65513834 0 kegg kegg NA NA no no no no no no Prion disease EGFR tyrosine kinase inhibitor resistance 0 0.748023715 0 kegg kegg NA NA no no no no no no Prion disease Endocrine and other factor-regulated calcium reabsorption 0.486956522 0.733201581 0 kegg kegg NA NA no no no no no no Prion disease Endocytosis -0.416521739 -0.419960474 0 kegg kegg NA NA no no no no no no Prion disease ErbB signaling pathway 0 -0.489130435 0 kegg kegg NA NA no no no no no no Prion disease Estrogen signaling pathway 0 0.424901186 0 kegg kegg NA NA no no no no no no Prion disease Ether lipid metabolism 0.587826087 0.449604743 0 kegg kegg NA NA no no no no no no Prion disease Fat digestion and absorption -0.468695652 -0.634387352 0 yes kegg kegg NA NA no no no no up up Prion disease Fatty acid biosynthesis -0.415652174 -0.839920949 -0.580694981 kegg kegg NA NA no no no no no no Prion disease Fatty acid degradation -0.579130435 -0.81916996 0 kegg kegg NA NA no no no no no no Prion disease Fatty acid elongation -0.416521739 0 0 kegg kegg NA NA no no no no no no Prion disease Fatty acid metabolism -0.688695652 -0.782608696 0 kegg kegg NA NA no no no no no no Prion disease Fc epsilon RI signaling pathway 0 -0.751976285 0 kegg kegg NA NA no no no no no no Prion disease Fc gamma R-mediated phagocytosis 0 -0.585968379 0 kegg kegg NA NA no no no no no no Prion disease Focal adhesion 0 0.596837945 0.593822394 kegg kegg NA NA no no no no up up Prion disease Folate biosynthesis 0 0.471343874 0 kegg kegg NA NA no no no no no no Prion disease FoxO signaling pathway 0 -0.788537549 0 kegg kegg NA NA no no no no no no Prion disease Fructose and mannose metabolism -0.710434783 -0.659090909 -0.524581725 kegg kegg NA NA no no no no no no Prion disease GABAergic synapse 0 -0.647233202 0 kegg kegg NA NA no no no no up up Prion disease Galactose metabolism -0.703478261 -0.785573123 0 kegg kegg NA NA no no no no no no Prion disease Gastric acid secretion 0 0.729249012 0.57014157 kegg kegg NA NA no no no no no no Prion disease Glucagon signaling pathway 0.424347826 0.719367589 0 kegg kegg NA NA no no no no no no Prion disease Glutathione metabolism 0 0.684782609 0 kegg kegg NA NA no no no no no no Prion disease Glycerolipid metabolism 0 -0.694664032 0 kegg kegg NA NA no no no no no up Prion disease Glycerophospholipid metabolism 0 -0.464426877 0 kegg kegg NA NA no no no no no up Prion disease Glycolysis / Gluconeogenesis -0.492173913 0.566205534 0 kegg kegg NA NA no no no no no no Prion disease Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.449565217 -0.828063241 0 kegg kegg NA NA no no no no no no Prion disease Glycosaminoglycan biosynthesis - keratan sulfate 0.415652174 0 0 kegg kegg NA NA no no no no no no Prion disease Glyoxylate and dicarboxylate metabolism -0.712173913 -0.748023715 -0.544916345 kegg kegg NA NA no no no no no no Prion disease GnRH secretion 0 -0.495059289 0 kegg kegg NA NA no no no no up up Prion disease Hedgehog signaling pathway 0.413043478 0 0 kegg kegg NA NA no no no no no no Prion disease HIF-1 signaling pathway 0 0.729249012 0 kegg kegg NA NA no no no no no no Prion disease Hippo signaling pathway 0 0.696640316 0.685199485 kegg kegg NA NA no no no no no no Prion disease Hippo signaling pathway - multiple species 0 -0.752964427 0 kegg kegg NA NA no no no no no no Prion disease Huntington disease 0.946956522 0.964426877 0.932046332 kegg kegg NA NA no no no no no no Prion disease IL-17 signaling pathway 0 -0.563241107 -0.457400257 kegg kegg NA NA no no no no no no Prion disease Inflammatory mediator regulation of TRP channels 0.524347826 0.779644269 0 kegg kegg NA NA no no no no no no Prion disease Inositol phosphate metabolism 0 -0.498023715 0 kegg kegg NA NA no no no no no no Prion disease Insulin resistance 0 -0.632411067 0 kegg kegg NA NA no no no no no no Prion disease Insulin secretion 0 0.422924901 0 yes kegg kegg NA NA no no no no up up Prion disease Insulin signaling pathway 0 0.780632411 0 kegg kegg NA NA no no no no no no Prion disease JAK-STAT signaling pathway 0 -0.81916996 0 kegg kegg NA NA no no no no no no Prion disease Long-term depression 0.513913043 0 0 kegg kegg NA NA no no no no no no Prion disease Long-term potentiation 0.417391304 0.508893281 0 kegg kegg NA NA no no no no no up Prion disease MAPK signaling pathway 0 -0.628458498 0 kegg kegg NA NA no no no no no no Prion disease Melanogenesis 0.522608696 0.806324111 0 kegg kegg NA NA no no no no no no Prion disease Metabolism of xenobiotics by cytochrome P450 0 0.54743083 0 kegg kegg NA NA no no no no no no Prion disease Mineral absorption 0 0.486166008 0 kegg kegg NA NA no no no no no no Prion disease Mitophagy - animal 0.434782609 0.748023715 0 kegg kegg NA NA no no no no no no Prion disease mRNA surveillance pathway 0.607826087 0.639328063 0 kegg kegg NA NA no no no no no no Prion disease mTOR signaling pathway 0 0.744071146 0 kegg kegg NA NA no no no no no no Prion disease N-Glycan biosynthesis 0 0.623517787 0 kegg kegg NA NA no no no no no no Prion disease Neuroactive ligand-receptor interaction 0 -0.433794466 0 kegg kegg NA NA no no no up up up Prion disease Neurotrophin signaling pathway 0.483478261 0 0 kegg kegg NA NA no no no no no no Prion disease Neutrophil extracellular trap formation -0.426956522 -0.503952569 0 kegg kegg NA NA no no no no no no Prion disease NF-kappa B signaling pathway 0 -0.787549407 -0.534877735 kegg kegg NA NA no no no no no no Prion disease Nicotinate and nicotinamide metabolism -0.43826087 -0.793478261 -0.506821107 kegg kegg NA NA no no no no no no Prion disease Nitrogen metabolism -0.50173913 -0.66798419 -0.499099099 kegg kegg NA NA no no no no no no Prion disease NOD-like receptor signaling pathway 0 -0.768774704 0 kegg kegg NA NA no no no no no no Prion disease Non-alcoholic fatty liver disease 0.933913043 0.912055336 0.825482625 kegg kegg NA NA no no no no no no Prion disease Non-homologous end-joining -0.503478261 0 0 kegg kegg NA NA no no no no no no Prion disease Notch signaling pathway 0 -0.446640316 0 kegg kegg NA NA no no no no no no Prion disease Olfactory transduction 0 -0.556324111 0 kegg kegg NA NA no no no no no no Prion disease Oocyte meiosis 0.505217391 0.605731225 0.432432432 kegg kegg NA NA no no no no no no Prion disease Oscillospira 0 -0.475296443 0 LPS-producing kegg Genus NA 0.62 no no no no no no Prion disease Osteoclast differentiation 0 -0.720355731 -0.411325611 kegg kegg NA NA no no no no no no Prion disease Other glycan degradation -0.419130435 -0.542490119 0 kegg kegg NA NA no no no no no no Prion disease Oxidative phosphorylation 0.976521739 0.975296443 0.958301158 kegg kegg NA NA no no no no no no Prion disease Pancreatic secretion 0.64 0.66798419 0 kegg kegg NA NA no no no no no no Prion disease Pantothenate and CoA biosynthesis 0 -0.799407115 -0.473873874 kegg kegg NA NA no no no no no dn Prion disease "Parathyroid hormone synthesis, secretion and action" 0.628695652 0.738142292 0 kegg kegg NA NA no no no no no no Prion disease Parkinson disease 0.756521739 0.922924901 0 kegg kegg NA NA no no no no no no Prion disease Pentose and glucuronate interconversions 0 0.636363636 0.492406692 kegg kegg NA NA no no no no no no Prion disease Pentose phosphate pathway -0.494782609 -0.53458498 -0.438095238 kegg kegg NA NA no no no no no no Prion disease Peroxisome -0.562608696 -0.742094862 0 kegg kegg NA NA no no no no no no Prion disease Phagosome -0.552173913 0 0 kegg kegg NA NA no no no no no no Prion disease Phenylalanine metabolism 0 0.423913043 0 kegg kegg NA NA no no no no no no Prion disease Phosphatidylinositol signaling system 0.467826087 0 0 kegg kegg NA NA no no no no no no Prion disease Phospholipase D signaling pathway 0 -0.658102767 0 kegg kegg NA NA no no no no up up Prion disease Phototransduction 0.410434783 0.644268775 0.516602317 kegg kegg NA NA no no no no no no Prion disease Platelet activation 0 0.551383399 0.432432432 kegg kegg NA NA no no no no no no Prion disease PPAR signaling pathway 0 -0.604743083 0 kegg kegg NA NA no no no no no no Prion disease Prolactin signaling pathway 0 -0.713438735 -0.47027027 kegg kegg NA NA no no no no no no Prion disease Propanoate metabolism 0 0.566205534 0 kegg kegg NA NA no no no no no no Prion disease Proteasome 0 0.593873518 0 kegg kegg NA NA no no no no no no Prion disease Protein digestion and absorption -0.669565217 -0.804347826 -0.503474903 yes kegg kegg NA NA no no no no up up Prion disease Protein export 0.525217391 0.846837945 0.462290862 kegg kegg NA NA no no no no no no Prion disease Protein processing in endoplasmic reticulum 0 0.672924901 0 kegg kegg NA NA no no no no no no Prion disease Proximal tubule bicarbonate reclamation 0 0.563241107 0 kegg kegg NA NA no no no no no no Prion disease Pyrimidine metabolism -0.663478261 0 0 kegg kegg NA NA no no no no no no Prion disease Pyruvate metabolism 0 0.665019763 0 kegg kegg NA NA no no no no no no Prion disease Rap1 signaling pathway 0 0 0.417245817 kegg kegg NA NA no no no no no no Prion disease Ras signaling pathway 0 0.610671937 0 yes kegg kegg NA NA no no no no up up Prion disease Regulation of actin cytoskeleton 0 0.496047431 0.542342342 kegg kegg NA NA no no no no no no Prion disease Relaxin signaling pathway 0.455652174 0 0 kegg kegg NA NA no no no no no no Prion disease Renin secretion 0 0.800395257 0 kegg kegg NA NA no no no no no no Prion disease Renin-angiotensin system 0 -0.54743083 0 kegg kegg NA NA no no no no no no Prion disease Retrograde endocannabinoid signaling 0.88173913 0.928853755 0.827799228 kegg kegg NA NA no no no no no up Prion disease Ribosome 0.628695652 0.891304348 0 kegg kegg NA NA no no no no no no Prion disease RIG-I-like receptor signaling pathway 0 -0.734189723 -0.488803089 kegg kegg NA NA no no no no no no Prion disease RNA degradation 0.564347826 0.703557312 0 kegg kegg NA NA no no no no no no Prion disease RNA polymerase 0 0.571146245 0 kegg kegg NA NA no no no no no no Prion disease RNA transport 0 0.660079051 0 kegg kegg NA NA no no no no no no Prion disease Signaling pathways regulating pluripotency of stem cells 0.506086957 0 0 kegg kegg NA NA no no no no no no Prion disease SNARE interactions in vesicular transport 0 -0.694664032 0 kegg kegg NA NA no no no no no no Prion disease Starch and sucrose metabolism -0.413043478 -0.849802372 0 kegg kegg NA NA no no no no no no Prion disease Sulfur metabolism -0.467826087 0 0 kegg kegg NA NA no no no no no no Prion disease Synaptic vesicle cycle 0 -0.537549407 0 kegg kegg NA NA no no no no up up Prion disease T cell receptor signaling pathway 0 -0.476284585 0 kegg kegg NA NA no no no no no no Prion disease Taurine and hypotaurine metabolism 0 -0.523715415 0 kegg kegg NA NA no no no no no no Prion disease TGF-beta signaling pathway 0.665217391 0.772727273 0.455083655 kegg kegg NA NA no no no no no no Prion disease Thermogenesis 0.936521739 0.982213439 0.937709138 kegg kegg NA NA no no no no no no Prion disease Thiamine metabolism 0 0.540513834 0 kegg kegg NA NA no no no no no no Prion disease Thyroid hormone signaling pathway 0 0.622529644 0.597683398 kegg kegg NA NA no no no no no no Prion disease Thyroid hormone synthesis 0 0.503952569 0 kegg kegg NA NA no no no no no no Prion disease Tight junction 0 0.590909091 0 kegg kegg NA NA no no no no no no Prion disease TNF signaling pathway 0 -0.606719368 0 kegg kegg NA NA no no no no no no Prion disease Toll-like receptor signaling pathway 0 -0.686758893 0 yes kegg kegg NA NA no no no no no no Prion disease Tryptophan metabolism -0.462608696 0 0 kegg kegg NA NA no no no no up no Prion disease Type I diabetes mellitus -0.459130435 0 0 kegg kegg NA NA no no no no no no Prion disease Type II diabetes mellitus 0 -0.666996047 -0.46023166 kegg kegg NA NA no no no no no no Prion disease Tyrosine metabolism 0 0.418972332 0 kegg kegg NA NA no no no no no no Prion disease Ubiquitin mediated proteolysis 0.433043478 0.766798419 0 kegg kegg NA NA no no no no no no Prion disease Various types of N-glycan biosynthesis 0 0.420948617 0 kegg kegg NA NA no no no no no no Prion disease Vascular smooth muscle contraction 0.66173913 0.847826087 0 kegg kegg NA NA no no no no no no Prion disease Vasopressin-regulated water reabsorption 0.533913043 0.701581028 0 kegg kegg NA NA no no no no no no Prion disease VEGF signaling pathway 0 -0.438735178 0 kegg kegg NA NA no no no no no no Prion disease Vitamin digestion and absorption 0.53826087 -0.446640316 0 kegg kegg NA NA no no no no no no Prion disease Wnt signaling pathway 0.637391304 0.681818182 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation ABC transporters 0 0.805335968 0 kegg kegg NA NA no no no no up up Progesterone-mediated oocyte maturation Adherens junction -0.62173913 -0.565217391 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Alistipes -0.410484263 0 0 kegg Genus NA 0.0114 no no no no up no Progesterone-mediated oocyte maturation Amino sugar and nucleotide sugar metabolism 0 0.438735178 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Aminoacyl-tRNA biosynthesis 0 0.568181818 0.481595882 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation AMPK signaling pathway 0 0 -0.511454311 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Antifolate resistance 0 0.545454545 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Antigen processing and presentation 0 -0.593873518 -0.43037323 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Apoptosis 0 0 -0.401544402 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Apoptosis - multiple species 0.467826087 0.831027668 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Arachidonic acid metabolism -0.553913043 -0.443675889 -0.776833977 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Arginine biosynthesis 0 0 -0.401801802 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Ascorbate and aldarate metabolism 0 0 0.558043758 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Autophagy - animal 0.694782609 0 0.497039897 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Autophagy - other 0.719130435 0.694664032 0.73976834 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Basal transcription factors 0.571304348 0.585968379 0.774517375 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Base excision repair 0.540869565 0.70256917 0.582754183 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Biosynthesis of amino acids 0 0 -0.592020592 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Biosynthesis of cofactors -0.479130435 0 -0.659202059 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation C-type lectin receptor signaling pathway 0.419130435 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Cell adhesion molecules 0 0 -0.431660232 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Cell cycle 0.605217391 0.595849802 0.715830116 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Chemokine signaling pathway 0 0 -0.470785071 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Cholinergic synapse 0.643478261 0 0.482110682 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Circadian entrainment 0 0 -0.425740026 kegg kegg NA NA no no no no up up Progesterone-mediated oocyte maturation Circadian rhythm 0.508695652 0.671936759 0.714028314 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Citrate cycle (TCA cycle) 0 0 0.491634492 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Complement and coagulation cascades 0 0 -0.539253539 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation DNA replication 0.420869565 0 0.556499356 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation ErbB signaling pathway 0.488695652 0.57312253 0.723552124 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Ether lipid metabolism 0 0 0.497297297 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Fanconi anemia pathway 0.476521739 0.782608696 0.655855856 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Ferroptosis -0.465217391 0 -0.676447876 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Focal adhesion -0.43826087 -0.551383399 0 kegg kegg NA NA no no no no up up Progesterone-mediated oocyte maturation FoxO signaling pathway 0.700869565 0.661067194 0.536936937 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Fructose and mannose metabolism 0 0.448616601 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Gap junction 0 0 -0.517374517 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Glutamatergic synapse 0 0 -0.476190476 kegg kegg NA NA no no no no up up Progesterone-mediated oocyte maturation Glutathione metabolism -0.585217391 0 -0.772458172 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Glycerolipid metabolism 0 0.759881423 0.683140283 kegg kegg NA NA no no no no no up Progesterone-mediated oocyte maturation Glycerophospholipid metabolism 0 0.746047431 0.786357786 kegg kegg NA NA no no no no no up Progesterone-mediated oocyte maturation "Glycine, serine and threonine metabolism" -0.512173913 0 -0.687773488 kegg kegg NA NA no no no no up no Progesterone-mediated oocyte maturation Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.531274131 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.433204633 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Glycosphingolipid biosynthesis - ganglio series 0 0.484189723 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.529565217 0.544466403 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Hedgehog signaling pathway 0 0.812252964 0.762934363 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Hippo signaling pathway -0.520869565 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Hippo signaling pathway - multiple species 0 0 0.478249678 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Homologous recombination 0.56173913 0.789525692 0.579407979 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation IL-17 signaling pathway 0 -0.416007905 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Inositol phosphate metabolism 0 0.877470356 0.762419562 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Intestinal immune network for IgA production 0 -0.423913043 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation JAK-STAT signaling pathway 0 0.576086957 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Lachnospira 0 -0.52087968 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Progesterone-mediated oocyte maturation Leukocyte transendothelial migration 0 -0.695652174 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Linoleic acid metabolism 0 0 0.435778636 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Long-term potentiation 0.569565217 0 0.606177606 kegg kegg NA NA no no no no no up Progesterone-mediated oocyte maturation Longevity regulating pathway 0 0 -0.463835264 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Longevity regulating pathway - multiple species 0.483478261 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Lysine degradation 0 0.803359684 0.75958816 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Lysosome 0 -0.564229249 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Mannose type O-glycan biosynthesis 0 0.592885375 0.677734878 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation MAPK signaling pathway 0.663478261 0.721343874 0.58043758 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Mitophagy - animal 0 0 -0.454311454 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation mRNA surveillance pathway 0 0 0.685456885 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Mucin type O-glycan biosynthesis 0 0.663043478 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation N-Glycan biosynthesis 0 0 0.600514801 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Necroptosis 0 0 -0.600772201 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Neutrophil extracellular trap formation 0 0 -0.528185328 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Nitrogen metabolism 0 0 -0.476190476 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Notch signaling pathway 0 0.467391304 0.652509653 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Nucleotide excision repair 0 0.418972332 0.476705277 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation One carbon pool by folate 0 0 0.555469755 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Oocyte meiosis 0.452173913 0 0.581724582 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Oscillospira 0 0.601778656 0 LPS-producing kegg Genus NA 0.62 no no no no no no Progesterone-mediated oocyte maturation Other glycan degradation 0 0.623517787 0.62960103 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Other types of O-glycan biosynthesis 0.453913043 0.795454545 0.796653797 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Ovarian steroidogenesis 0 0 -0.466409266 kegg kegg NA NA no no no no up up Progesterone-mediated oocyte maturation p53 signaling pathway 0.532173913 0.694664032 0.437580438 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Pentose phosphate pathway 0 0 -0.464864865 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Phagosome -0.460869565 0 -0.592535393 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Phenylalanine metabolism -0.430434783 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Phosphatidylinositol signaling system 0.445217391 0.695652174 0.822651223 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Phototransduction 0 -0.486166008 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation PI3K-Akt signaling pathway 0.613043478 0 0 yes kegg kegg NA NA no no no no up up Progesterone-mediated oocyte maturation Platelet activation -0.602608696 -0.596837945 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Platinum drug resistance 0.646956522 0.890316206 0.575289575 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Porphyrin and chlorophyll metabolism -0.488695652 0 -0.701415701 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Protein export 0.454782609 0 0.563449163 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Purine metabolism 0 0 -0.453024453 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Rap1 signaling pathway -0.5 -0.614624506 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Ras signaling pathway 0 0 0.624967825 yes kegg kegg NA NA no no no no up up Progesterone-mediated oocyte maturation Regulation of actin cytoskeleton -0.423478261 -0.564229249 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Retinol metabolism 0 0 0.495238095 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Ribosome biogenesis in eukaryotes 0.539130435 0.634387352 0.727670528 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation RIG-I-like receptor signaling pathway 0.470434783 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation RNA degradation 0 0 0.725611326 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation RNA polymerase 0.472173913 0.43972332 0.549034749 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation RNA transport 0.426956522 0 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Ruminococcus 0 -0.433384192 0 kegg Genus NA 0.0679 no no no no no dn Progesterone-mediated oocyte maturation Selenocompound metabolism 0.528695652 0.888339921 0.714028314 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Serotonergic synapse 0 0 -0.647876448 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Signaling pathways regulating pluripotency of stem cells 0.586086957 0.668972332 0.810810811 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation SNARE interactions in vesicular transport 0 0.510869565 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Sphingolipid signaling pathway 0.464347826 0 0.644272844 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Spliceosome 0.70173913 0.882411067 0.735392535 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Steroid biosynthesis 0 0 0.473873874 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Sulfur metabolism -0.566956522 0 -0.708622909 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Synthesis and degradation of ketone bodies 0 0.445652174 0.516859717 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation T cell receptor signaling pathway 0.716521739 0.53458498 0.561647362 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Taste transduction 0.42 0.513833992 0.783268983 kegg kegg NA NA no no no no no up Progesterone-mediated oocyte maturation Taurine and hypotaurine metabolism 0 0.693675889 0.555984556 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Terpenoid backbone biosynthesis 0.533913043 0.483201581 0.609266409 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation TGF-beta signaling pathway 0 0 0.585842986 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Tight junction -0.691304348 -0.666007905 -0.558301158 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Ubiquitin mediated proteolysis 0 0 -0.438352638 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Various types of N-glycan biosynthesis 0.580869565 0 0.658687259 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Vascular smooth muscle contraction 0 -0.444664032 0 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation VEGF signaling pathway 0.469565217 0 0.635521236 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Viral protein interaction with cytokine and cytokine receptor 0 -0.649209486 -0.517889318 kegg kegg NA NA no no no no no no Progesterone-mediated oocyte maturation Wnt signaling pathway 0 0 0.732303732 kegg kegg NA NA no no no no no no Prolactin signaling pathway 2-Oxocarboxylic acid metabolism -0.56173913 -0.57312253 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Adherens junction 0 -0.476284585 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Adrenergic signaling in cardiomyocytes 0 -0.656126482 0 kegg kegg NA NA no no no no no up Prolactin signaling pathway "Alanine, aspartate and glutamate metabolism" 0 0.640316206 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway alpha-Linolenic acid metabolism 0 0.490118577 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Amino sugar and nucleotide sugar metabolism -0.506086957 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Aminoacyl-tRNA biosynthesis -0.412173913 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Apelin signaling pathway 0 -0.772727273 -0.450965251 kegg kegg NA NA no no no no no no Prolactin signaling pathway Apoptosis 0 0.77173913 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Arachidonic acid metabolism -0.573043478 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Arginine and proline metabolism 0 0.599802372 0 kegg kegg NA NA no no no no up no Prolactin signaling pathway Arginine biosynthesis 0 0.62055336 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Ascorbate and aldarate metabolism -0.466956522 -0.482213439 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Autophagy - animal 0.603478261 0.716403162 0.477992278 kegg kegg NA NA no no no no no no Prolactin signaling pathway B cell receptor signaling pathway 0 0.767786561 0.493951094 kegg kegg NA NA no no no no no no Prolactin signaling pathway Bacteroides 0 -0.505928854 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Prolactin signaling pathway Basal transcription factors 0 -0.432806324 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Base excision repair 0 -0.442687747 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway beta-Alanine metabolism -0.56173913 -0.432806324 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Biosynthesis of amino acids 0 0.51284585 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Biosynthesis of cofactors -0.627826087 -0.592885375 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Biosynthesis of unsaturated fatty acids -0.486086957 0 -0.402059202 kegg kegg NA NA no no no no no no Prolactin signaling pathway Butanoate metabolism -0.676521739 -0.687747036 -0.567310167 kegg kegg NA NA no no no no no no Prolactin signaling pathway Butyricimonas 0.541322547 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Prolactin signaling pathway C-type lectin receptor signaling pathway 0.653043478 0.828063241 0.642985843 kegg kegg NA NA no no no no no no Prolactin signaling pathway cAMP signaling pathway 0.539130435 0.476284585 0 yes kegg kegg NA NA no no no no up up Prolactin signaling pathway Carbon metabolism -0.486956522 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Cardiac muscle contraction 0 -0.576086957 0 kegg kegg NA NA no no no no no up Prolactin signaling pathway Cell adhesion molecules 0 0.443675889 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Cell cycle 0 -0.566205534 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Cellular senescence 0 0.627470356 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway cGMP-PKG signaling pathway 0.564347826 0.623517787 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Chemokine signaling pathway 0.41826087 0.570158103 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Cholinergic synapse 0.704347826 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Circadian entrainment 0 -0.548418972 0 kegg kegg NA NA no no no no up up Prolactin signaling pathway Citrate cycle (TCA cycle) -0.563478261 -0.77173913 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Collinsella 0 0 -0.41335855 kegg Genus NA 0.128 no no no no no no Prolactin signaling pathway Complement and coagulation cascades 0 0.551383399 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Cysteine and methionine metabolism -0.412173913 -0.707509881 -0.487001287 kegg kegg NA NA no no no no no no Prolactin signaling pathway DNA replication 0 -0.760869565 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Dopaminergic synapse 0 -0.695652174 0 kegg kegg NA NA no no no no up no Prolactin signaling pathway Drug metabolism - cytochrome P450 -0.436521739 -0.831027668 -0.508108108 kegg kegg NA NA no no no no no no Prolactin signaling pathway Drug metabolism - other enzymes -0.569565217 -0.730237154 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway ECM-receptor interaction -0.482608696 -0.509881423 0 kegg kegg NA NA no no no no up up Prolactin signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.609683794 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Endocytosis 0 0.496047431 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway ErbB signaling pathway 0.643478261 0.585968379 0.496010296 kegg kegg NA NA no no no no no no Prolactin signaling pathway Estrogen signaling pathway 0 -0.624505929 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Ether lipid metabolism 0 -0.456521739 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Fatty acid biosynthesis 0.487826087 0.733201581 0.616216216 kegg kegg NA NA no no no no no no Prolactin signaling pathway Fatty acid degradation 0 0.479249012 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Fatty acid elongation -0.586086957 -0.455533597 -0.538223938 kegg kegg NA NA no no no no no no Prolactin signaling pathway Fatty acid metabolism 0 0.423913043 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Fc epsilon RI signaling pathway 0.723478261 0.841897233 0.522265122 kegg kegg NA NA no no no no no no Prolactin signaling pathway Fc gamma R-mediated phagocytosis 0 0.56916996 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Focal adhesion 0 -0.508893281 0 kegg kegg NA NA no no no no up up Prolactin signaling pathway FoxO signaling pathway 0.45826087 0.595849802 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Fructose and mannose metabolism -0.413043478 0.51284585 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Galactose metabolism 0 0.636363636 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Glutathione metabolism -0.495652174 -0.697628458 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Glycerolipid metabolism 0 0.445652174 0 kegg kegg NA NA no no no no no up Prolactin signaling pathway "Glycine, serine and threonine metabolism" -0.488695652 -0.43083004 0 kegg kegg NA NA no no no no up no Prolactin signaling pathway Glycolysis / Gluconeogenesis -0.555652174 -0.56916996 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.500869565 0.791501976 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.496521739 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 -0.443675889 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.414031621 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.625494071 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway HIF-1 signaling pathway 0 -0.608695652 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Hippo signaling pathway 0 -0.518774704 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Hippo signaling pathway - multiple species 0 0.519762846 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway IL-17 signaling pathway 0.405217391 0.650197628 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Inflammatory mediator regulation of TRP channels 0 -0.56916996 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Insulin signaling pathway 0 -0.710474308 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway JAK-STAT signaling pathway 0 0.695652174 0.547747748 kegg kegg NA NA no no no no no no Prolactin signaling pathway Linoleic acid metabolism -0.536521739 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Long-term potentiation 0 -0.665019763 0 kegg kegg NA NA no no no no no up Prolactin signaling pathway Lysosome 0 0.427865613 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway MAPK signaling pathway 0 0 0.495238095 kegg kegg NA NA no no no no no no Prolactin signaling pathway Melanogenesis 0 -0.583992095 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Metabolism of xenobiotics by cytochrome P450 -0.443478261 -0.795454545 -0.527670528 kegg kegg NA NA no no no no no no Prolactin signaling pathway Mismatch repair -0.573043478 -0.739130435 -0.457400257 kegg kegg NA NA no no no no no no Prolactin signaling pathway Mitophagy - animal 0 -0.447628458 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway mRNA surveillance pathway 0 -0.542490119 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway mTOR signaling pathway 0 -0.603754941 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway N-Glycan biosynthesis 0 -0.684782609 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Natural killer cell mediated cytotoxicity 0 0.566205534 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Neuroactive ligand-receptor interaction 0 0.420948617 0 kegg kegg NA NA no no no up up up Prolactin signaling pathway Neurotrophin signaling pathway 0.474782609 0.637351779 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Neutrophil extracellular trap formation 0 0.555335968 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway NF-kappa B signaling pathway 0 0.739130435 0.62985843 kegg kegg NA NA no no no no no no Prolactin signaling pathway Nicotinate and nicotinamide metabolism 0 0.7243083 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Nitrogen metabolism 0 0.545454545 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway NOD-like receptor signaling pathway 0 0.759881423 0.507078507 kegg kegg NA NA no no no no no no Prolactin signaling pathway Non-homologous end-joining -0.526086957 -0.544466403 -0.428571429 kegg kegg NA NA no no no no no no Prolactin signaling pathway Notch signaling pathway 0.486956522 0 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Nucleotide excision repair -0.424347826 -0.720355731 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Olfactory transduction 0 0.433794466 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway One carbon pool by folate 0 -0.598814229 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Oocyte meiosis 0 -0.707509881 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Osteoclast differentiation 0 0.829051383 0.493693694 kegg kegg NA NA no no no no no no Prolactin signaling pathway Oxidative phosphorylation 0 -0.623517787 -0.403603604 kegg kegg NA NA no no no no no no Prolactin signaling pathway Pantothenate and CoA biosynthesis 0 0.632411067 0 kegg kegg NA NA no no no no no dn Prolactin signaling pathway Pentose and glucuronate interconversions -0.706086957 -0.759881423 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Pentose phosphate pathway 0 0.571146245 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Peroxisome 0 0.579051383 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Phagosome 0 0.506916996 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Phenylalanine metabolism -0.506086957 -0.635375494 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Phospholipase D signaling pathway 0.551304348 0.669960474 0 kegg kegg NA NA no no no no up up Prolactin signaling pathway Phototransduction 0 -0.646245059 -0.527670528 kegg kegg NA NA no no no no no no Prolactin signaling pathway Platelet activation 0 -0.414031621 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway PPAR signaling pathway 0 0.660079051 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Prevotella 0 0.420766661 0 acetate-producing kegg Genus NA 0.287 no no no no no no Prolactin signaling pathway Primary bile acid biosynthesis -0.605217391 -0.482213439 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Propanoate metabolism -0.417391304 -0.677865613 -0.488288288 kegg kegg NA NA no no no no no no Prolactin signaling pathway Proteasome 0 -0.581027668 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Protein export 0 -0.748023715 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Protein processing in endoplasmic reticulum -0.436521739 -0.756916996 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Pyrimidine metabolism -0.413043478 -0.630434783 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Pyruvate metabolism -0.467826087 -0.752964427 -0.526898327 kegg kegg NA NA no no no no no no Prolactin signaling pathway Ras signaling pathway 0 -0.687747036 0 yes kegg kegg NA NA no no no no up up Prolactin signaling pathway Regulation of actin cytoskeleton 0 -0.527667984 -0.536422136 kegg kegg NA NA no no no no no no Prolactin signaling pathway Renin-angiotensin system 0 0.583992095 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Retinol metabolism 0 -0.527667984 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Retrograde endocannabinoid signaling 0 -0.747035573 0 kegg kegg NA NA no no no no no up Prolactin signaling pathway Ribosome 0 -0.648221344 -0.505791506 kegg kegg NA NA no no no no no no Prolactin signaling pathway Ribosome biogenesis in eukaryotes 0 -0.472332016 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway RIG-I-like receptor signaling pathway 0.50173913 0.710474308 0.55958816 kegg kegg NA NA no no no no no no Prolactin signaling pathway RNA degradation 0 -0.617588933 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway RNA polymerase 0 -0.600790514 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway RNA transport -0.451304348 -0.552371542 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Sarcina 0 0.422326513 0 kegg Genus NA 0.0703 no no no no no no Prolactin signaling pathway Signaling pathways regulating pluripotency of stem cells 0.536521739 0 0.402059202 kegg kegg NA NA no no no no no no Prolactin signaling pathway Sphingolipid signaling pathway 0.739130435 0.518774704 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Starch and sucrose metabolism 0 0.675889328 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Steroid biosynthesis 0 -0.568181818 -0.426512227 kegg kegg NA NA no no no no no no Prolactin signaling pathway Steroid hormone biosynthesis -0.611304348 -0.526679842 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Sulfur metabolism -0.615652174 -0.511857708 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Synaptic vesicle cycle 0.415652174 0.480237154 0 kegg kegg NA NA no no no no up up Prolactin signaling pathway Synthesis and degradation of ketone bodies -0.41826087 -0.603754941 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway T cell receptor signaling pathway 0 0.441699605 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Taste transduction 0 -0.533596838 0 kegg kegg NA NA no no no no no up Prolactin signaling pathway Taurine and hypotaurine metabolism 0 0.454545455 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway TGF-beta signaling pathway 0 -0.65513834 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Th1 and Th2 cell differentiation 0 0.515810277 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Th17 cell differentiation 0 0.515810277 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Thermogenesis 0 -0.67687747 -0.55958816 kegg kegg NA NA no no no no no no Prolactin signaling pathway Thiamine metabolism 0 -0.677865613 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Tight junction 0 -0.489130435 -0.42960103 kegg kegg NA NA no no no no no no Prolactin signaling pathway TNF signaling pathway 0.584347826 0.754940711 0.534877735 kegg kegg NA NA no no no no no no Prolactin signaling pathway Toll-like receptor signaling pathway 0.659130435 0.804347826 0.4996139 yes kegg kegg NA NA no no no no no no Prolactin signaling pathway Tryptophan metabolism -0.617391304 -0.587944664 0 kegg kegg NA NA no no no no up no Prolactin signaling pathway Tyrosine metabolism -0.497391304 -0.678853755 -0.494980695 kegg kegg NA NA no no no no no no Prolactin signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.653913043 -0.663043478 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Ubiquitin mediated proteolysis 0 -0.554347826 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway "Valine, leucine and isoleucine degradation" -0.64173913 -0.690711462 -0.439382239 kegg kegg NA NA no no no no no no Prolactin signaling pathway Various types of N-glycan biosynthesis 0 -0.555335968 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Vascular smooth muscle contraction 0 -0.666996047 -0.428056628 kegg kegg NA NA no no no no no no Prolactin signaling pathway VEGF signaling pathway 0.76173913 0.614624506 0 kegg kegg NA NA no no no no no no Prolactin signaling pathway Wnt signaling pathway 0 -0.605731225 0 kegg kegg NA NA no no no no no no Propanoate metabolism "Alanine, aspartate and glutamate metabolism" 0 -0.539525692 0 kegg kegg NA NA no no no no no no Propanoate metabolism alpha-Linolenic acid metabolism 0.477391304 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Amino sugar and nucleotide sugar metabolism 0.665217391 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Arginine and proline metabolism 0 -0.581027668 -0.453539254 kegg kegg NA NA no no no no up no Propanoate metabolism Arginine biosynthesis 0 -0.530632411 0 kegg kegg NA NA no no no no no no Propanoate metabolism beta-Alanine metabolism 0.506956522 0.623517787 0.501415701 kegg kegg NA NA no no no no no no Propanoate metabolism Citrate cycle (TCA cycle) 0.727826087 0.855731225 0.587644788 kegg kegg NA NA no no no no no no Propanoate metabolism Cysteine and methionine metabolism 0.946956522 0.986166008 0.943886744 kegg kegg NA NA no no no no no no Propanoate metabolism Fatty acid biosynthesis 0 -0.520750988 0 kegg kegg NA NA no no no no no no Propanoate metabolism Fatty acid degradation 0.475652174 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Fatty acid elongation 0.47826087 0.722332016 0.657142857 kegg kegg NA NA no no no no no no Propanoate metabolism Fructose and mannose metabolism 0 -0.584980237 0 kegg kegg NA NA no no no no no no Propanoate metabolism Glutathione metabolism 0 0.559288538 0 kegg kegg NA NA no no no no no no Propanoate metabolism Glycerolipid metabolism 0 -0.437747036 0 kegg kegg NA NA no no no no no up Propanoate metabolism Glycolysis / Gluconeogenesis 0.733043478 0.860671937 0.465379665 kegg kegg NA NA no no no no no no Propanoate metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.817193676 0 kegg kegg NA NA no no no no no no Propanoate metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.629565217 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Glycosaminoglycan degradation -0.426086957 -0.440711462 0 kegg kegg NA NA no no no no no up Propanoate metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.706086957 -0.572134387 0 kegg kegg NA NA no no no no no no Propanoate metabolism Glyoxylate and dicarboxylate metabolism 0 -0.502964427 0 kegg kegg NA NA no no no no no no Propanoate metabolism Histidine metabolism 0.415652174 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Mannose type O-glycan biosynthesis -0.546956522 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Mucin type O-glycan biosynthesis 0.749565217 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism N-Glycan biosynthesis 0 0.611660079 0.434234234 kegg kegg NA NA no no no no no no Propanoate metabolism Other glycan degradation 0 -0.450592885 0 kegg kegg NA NA no no no no no no Propanoate metabolism Oxidative phosphorylation 0 0.43972332 0 kegg kegg NA NA no no no no no no Propanoate metabolism Pentose and glucuronate interconversions 0.695652174 0.744071146 0.515315315 kegg kegg NA NA no no no no no no Propanoate metabolism Phenylalanine metabolism 0 0.660079051 0 kegg kegg NA NA no no no no no no Propanoate metabolism Primary bile acid biosynthesis 0.712173913 0.72826087 0 kegg kegg NA NA no no no no no no Propanoate metabolism Pyrimidine metabolism 0.553043478 0.492094862 0 kegg kegg NA NA no no no no no no Propanoate metabolism Pyruvate metabolism 0.932173913 0.967391304 0.87001287 kegg kegg NA NA no no no no no no Propanoate metabolism Sphingolipid metabolism -0.48173913 0 0 kegg kegg NA NA no no no no no no Propanoate metabolism Starch and sucrose metabolism 0 -0.493083004 0 kegg kegg NA NA no no no no no no Propanoate metabolism Steroid biosynthesis 0 0.705533597 0.525353925 kegg kegg NA NA no no no no no no Propanoate metabolism Steroid hormone biosynthesis 0.622608696 0.619565217 0 kegg kegg NA NA no no no no no no Propanoate metabolism Synthesis and degradation of ketone bodies 0.817391304 0.701581028 0.605405405 kegg kegg NA NA no no no no no no Propanoate metabolism Taurine and hypotaurine metabolism 0 -0.578063241 0 kegg kegg NA NA no no no no no no Propanoate metabolism Tryptophan metabolism 0.666086957 0.760869565 0.562676963 kegg kegg NA NA no no no no up no Propanoate metabolism Tyrosine metabolism 0.679130435 0.773715415 0.568854569 kegg kegg NA NA no no no no no no Propanoate metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.648695652 0.645256917 0.585585586 kegg kegg NA NA no no no no no no Propanoate metabolism "Valine, leucine and isoleucine degradation" 0.760869565 0.72826087 0.724324324 kegg kegg NA NA no no no no no no Propanoate metabolism Various types of N-glycan biosynthesis 0 0.517786561 0.421621622 kegg kegg NA NA no no no no no no propionic acid C3+blood 14:0/16:0-PC+blood 0 -0.588235294 0 serum_scfa serum_phospholipids 0.104 0.0358 no dn no no up no propionic acid C3+blood 14:0/18:2-PC+blood 0 0 -0.404444444 serum_scfa serum_phospholipids 0.104 0.102 no dn no no up no propionic acid C3+blood 16:0/18:3-PC+blood 0 -0.487745098 0 serum_scfa serum_phospholipids 0.104 0.00216 no dn no no up up propionic acid C3+blood 16:0/20:5-PG+blood 0 0 0.526153846 serum_scfa serum_phospholipids 0.104 0.00656 no dn no no up no propionic acid C3+blood 18:0/18:0-PC+blood 0.506766917 0 0 serum_scfa serum_phospholipids 0.104 0.426 no dn no no no no propionic acid C3+blood 18:0/20:2-PC+blood 0 0 -0.446153846 serum_scfa serum_phospholipids 0.104 0.733 no dn no no no no propionic acid C3+blood 18:0+blood 0.45112782 0 0 serum_scfa serum_fattyacid 0.104 0.344 no dn no no no no propionic acid C3+blood 18:1-LPC+blood 0 0.710784314 0 serum_scfa serum_phospholipids 0.104 0.179 no dn no no no no propionic acid C3+blood 18:1/18:2-PI+blood -0.541353383 0 0 serum_scfa serum_phospholipids 0.104 0.0164 no dn no dn no up propionic acid C3+blood 18:2/18:2-PS+blood 0 0 0.468034188 serum_scfa serum_phospholipids 0.104 0.00674 no dn no up up no propionic acid C3+blood 18:3/18:2-PC+blood 0 0 -0.406495726 serum_scfa serum_phospholipids 0.104 0.0394 no dn no no no up propionic acid C3+blood 2-methyl-butyric acid m-C4+blood 0.551879699 0 0.556239316 serum_scfa serum_scfa 0.104 0.262 no dn no no no no propionic acid C3+blood 20:0-LPC+blood 0 0.568627451 -0.418803419 serum_scfa serum_phospholipids 0.104 0.199 no dn no no no no propionic acid C3+blood 20:1-LPC+blood 0 0.735294118 0 serum_scfa serum_phospholipids 0.104 0.217 no dn no no no no propionic acid C3+blood 20:2-LPC+blood -0.494736842 0 0 serum_scfa serum_phospholipids 0.104 0.119 no dn no no no up propionic acid C3+blood 22:2-LPA+blood -0.584962406 0 0 serum_scfa serum_phospholipids 0.104 0.0443 no dn no dn no no propionic acid C3+blood 9-HODE+blood -0.571428571 0 0 serum_scfa serum_ARA 0.104 0.297 no dn no no no no propionic acid C3+blood acetic acid C2+blood 0.694736842 0.514705882 0 serum_scfa serum_scfa 0.104 0.000193 no dn no up dn no propionic acid C3+blood butyric acid C4+blood 0.613533835 0 0.688888889 serum_scfa serum_scfa 0.104 0.407 no dn no no no no propionic acid C3+blood d18:0-16:0-SM+blood 0 0 0.401709402 serum_scfa serum_phospholipids 0.104 0.202 no dn no no no no propionic acid C3+blood d18:1-16:0-SM+blood 0 0 0.417435897 serum_scfa serum_phospholipids 0.104 0.14 no dn no no no no propionic acid C3+blood d18:1-18:0-SM+blood 0 0 0.437948718 serum_scfa serum_phospholipids 0.104 0.97 no dn no no no no propionic acid C3+blood d18:1-18:1-SM+blood 0 0 0.496068376 serum_scfa serum_phospholipids 0.104 0.916 no dn no no no no propionic acid C3+blood d18:1-20:1-SM+blood 0 0.517156863 0 serum_scfa serum_phospholipids 0.104 0.0992 no dn no no no no propionic acid C3+blood decanoic acid C10+blood 0.463157895 0 0 serum_scfa serum_mcfa 0.104 6.64E-11 no dn no dn dn no propionic acid C3+blood heptanoic acid C7+blood 0.709774436 0 0.402393162 serum_scfa serum_mcfa 0.104 8.27E-11 no dn no dn dn no propionic acid C3+blood iso-LCA+blood 0 0.676820944 0 serum_scfa serum_bileacids 0.104 0.507 no dn no no no no propionic acid C3+blood isobutyric acid C4+blood 0.637593985 0 0.757264957 serum_scfa serum_scfa 0.104 0.0151 no dn no up up no propionic acid C3+blood isovaleric acid iso-C5+blood 0 0 0.426324786 serum_scfa serum_scfa 0.104 0.117 no dn no no no no propionic acid C3+blood L-Ornithine+blood 0 0.522058824 0 serum_scfa serum_aminoacids 0.104 0.175 no dn no no no no propionic acid C3+blood nonanoic acid C9+blood 0.645112782 0 0 serum_scfa serum_mcfa 0.104 6.51E-11 no dn no dn dn no propionic acid C3+blood octanoic acid C8+blood 0.660150376 0 0 serum_scfa serum_mcfa 0.104 2.84E-11 no dn no dn dn dn Propionic acid+stool 5-Hydroxytryptamine+stool -0.581011352 0 -0.638339921 yes stool_scfa stool_cometabolism 0.0436 0.00862 dn no up dn dn no Propionic acid+stool Acetic acid+stool 0.7750258 0 0.769762846 yes yes stool_scfa stool_scfa 0.0436 0.0656 dn no up dn no no Propionic acid+stool Anaerostipes 0 0.598606393 0 yes butyrate-producing stool_scfa Genus 0.0436 0.568 dn no up no no no Propionic acid+stool Apelin signaling pathway 0.578947368 0 0 yes stool_scfa kegg 0.0436 NA dn no up no no no Propionic acid+stool Butyric acid+stool 0.512899897 0 0.609683794 yes yes stool_scfa stool_scfa 0.0436 0.102 dn no up dn no no Propionic acid+stool CA+stool -0.564499484 0 0 yes stool_scfa stool_bileacids 0.0436 0.827 dn no up no no no Propionic acid+stool Chemokine signaling pathway -0.566563467 0 0 yes stool_scfa kegg 0.0436 NA dn no up no no no Propionic acid+stool Coprococcus 0 -0.622377622 0 yes butyrate-producing stool_scfa Genus 0.0436 0.612 dn no up no no no Propionic acid+stool DCA+stool 0 0 0.56027668 yes stool_scfa stool_bileacids 0.0436 0.195 dn no up no no no Propionic acid+stool EGFR tyrosine kinase inhibitor resistance 0.622291022 0 0 yes stool_scfa kegg 0.0436 NA dn no up no no no Propionic acid+stool Epithelial cell signaling in Helicobacter pylori infection -0.488132095 0 0 yes stool_scfa kegg 0.0436 NA dn no up no no no Propionic acid+stool GCA+stool -0.479876161 0 0 yes stool_scfa stool_bileacids 0.0436 0.0809 dn no up no no no Propionic acid+stool GCDCA+stool -0.494324045 0 0 yes yes stool_scfa stool_bileacids 0.0436 0.0471 dn no up no dn no Propionic acid+stool GDCA+stool -0.494579312 0 -0.521266328 yes stool_scfa stool_bileacids 0.0436 0.656 dn no up no no no Propionic acid+stool HIF-1 signaling pathway 0.547987616 0 0 yes stool_scfa kegg 0.0436 NA dn no up no no no Propionic acid+stool Inflammatory bowel disease 0 -0.618181818 0 yes stool_scfa kegg 0.0436 NA dn no up no no no Propionic acid+stool Insulin signaling pathway 0.568627451 0 0 yes stool_scfa kegg 0.0436 NA dn no up no no no Propionic acid+stool iso-DCA+stool 0 0.734265734 0 yes stool_scfa stool_bileacids 0.0436 0.155 dn no up no no no Propionic acid+stool mTOR signaling pathway 0.585139319 0 0 yes stool_scfa kegg 0.0436 NA dn no up no no no Propionic acid+stool PI3K-Akt signaling pathway 0 0.618181818 0 yes yes stool_scfa kegg 0.0436 NA dn no up no up up Propionic acid+stool Renal cell carcinoma 0 0.663636364 0 yes stool_scfa kegg 0.0436 NA dn no up no no no Propionic acid+stool Ribosome biogenesis in eukaryotes 0.469556244 0 0 yes stool_scfa kegg 0.0436 NA dn no up no no no Propionic acid+stool ¦Ø-MCA+stool -0.640115782 0 0 yes stool_scfa stool_bileacids 0.0436 0.919 dn no up no no no Prostate cancer 2-Oxocarboxylic acid metabolism -0.595652174 -0.446640316 0 kegg kegg NA NA no no no no no no Prostate cancer Adherens junction -0.405217391 -0.532608696 -0.423680824 kegg kegg NA NA no no no no no no Prostate cancer Adipocytokine signaling pathway 0 0.725296443 0 kegg kegg NA NA no no no no no no Prostate cancer AGE-RAGE signaling pathway in diabetic complications 0 0.577075099 0 kegg kegg NA NA no no no no no no Prostate cancer "Alanine, aspartate and glutamate metabolism" 0 0.491106719 0 kegg kegg NA NA no no no no no no Prostate cancer Aldosterone-regulated sodium reabsorption 0.667826087 0.623517787 0 kegg kegg NA NA no no no no no no Prostate cancer Amino sugar and nucleotide sugar metabolism -0.553043478 0 -0.41003861 kegg kegg NA NA no no no no no no Prostate cancer Aminoacyl-tRNA biosynthesis 0 -0.450592885 0 kegg kegg NA NA no no no no no no Prostate cancer Amoebiasis 0 0.511857708 0 kegg kegg NA NA no no no no no no Prostate cancer Amphetamine addiction 0 -0.572134387 0 kegg kegg NA NA no no no no no no Prostate cancer Amyotrophic lateral sclerosis 0 -0.443675889 0 kegg kegg NA NA no no no no no no Prostate cancer Anaerostipes 0 0 -0.444219351 butyrate-producing kegg Genus NA 0.568 no no no no no no Prostate cancer Apelin signaling pathway 0 -0.482213439 0 kegg kegg NA NA no no no no no no Prostate cancer Apoptosis 0 0.706521739 0 kegg kegg NA NA no no no no no no Prostate cancer Arachidonic acid metabolism -0.657391304 0 -0.448648649 kegg kegg NA NA no no no no no no Prostate cancer Arginine and proline metabolism 0 0.558300395 0 kegg kegg NA NA no no no no up no Prostate cancer Arginine biosynthesis 0 0.475296443 0 kegg kegg NA NA no no no no no no Prostate cancer Ascorbate and aldarate metabolism 0 -0.419960474 0 kegg kegg NA NA no no no no no no Prostate cancer Autophagy - animal 0.673913043 0.773715415 0 kegg kegg NA NA no no no no no no Prostate cancer Autophagy - other 0.668695652 0.517786561 0.523552124 kegg kegg NA NA no no no no no no Prostate cancer Axon guidance 0.693043478 0 0 kegg kegg NA NA no no no no up up Prostate cancer B cell receptor signaling pathway 0.602608696 0.856719368 0.725353925 kegg kegg NA NA no no no no no no Prostate cancer Bacterial invasion of epithelial cells -0.457391304 -0.480237154 -0.565250965 kegg kegg NA NA no no no no no no Prostate cancer Basal transcription factors 0 -0.414031621 0 kegg kegg NA NA no no no no no no Prostate cancer beta-Alanine metabolism -0.67826087 -0.635375494 -0.729214929 kegg kegg NA NA no no no no no no Prostate cancer Biosynthesis of amino acids -0.456521739 0 0 kegg kegg NA NA no no no no no no Prostate cancer Biosynthesis of cofactors -0.56173913 -0.557312253 0 kegg kegg NA NA no no no no no no Prostate cancer Biosynthesis of unsaturated fatty acids -0.552173913 -0.694664032 -0.701673102 kegg kegg NA NA no no no no no no Prostate cancer Butanoate metabolism -0.59826087 -0.726284585 -0.590733591 kegg kegg NA NA no no no no no no Prostate cancer C-type lectin receptor signaling pathway 0.853043478 0.887351779 0.854826255 kegg kegg NA NA no no no no no no Prostate cancer Calcium signaling pathway 0 0 0.505534106 kegg kegg NA NA no no no no up up Prostate cancer cAMP signaling pathway 0.636521739 0.731225296 0.670527671 yes kegg kegg NA NA no no no no up up Prostate cancer Carbohydrate digestion and absorption 0.724347826 0.672924901 0 kegg kegg NA NA no no no no no no Prostate cancer Carbon metabolism -0.599130435 0 -0.451737452 kegg kegg NA NA no no no no no no Prostate cancer Cell cycle 0 -0.448616601 0 kegg kegg NA NA no no no no no no Prostate cancer Cellular senescence 0 0.579051383 0 kegg kegg NA NA no no no no no no Prostate cancer cGMP-PKG signaling pathway 0.407826087 0 0 kegg kegg NA NA no no no no no no Prostate cancer Chagas disease 0.633043478 0.811264822 0.521235521 kegg kegg NA NA no no no no no no Prostate cancer Chemical carcinogenesis - DNA adducts -0.47826087 0 0 kegg kegg NA NA no no no no no no Prostate cancer Chemokine signaling pathway 0.451304348 0.545454545 0 kegg kegg NA NA no no no no no no Prostate cancer Cholinergic synapse 0.507826087 0 0.430888031 kegg kegg NA NA no no no no no no Prostate cancer Circadian entrainment 0 -0.73715415 0 kegg kegg NA NA no no no no up up Prostate cancer Circadian rhythm 0.653043478 0 0.482882883 kegg kegg NA NA no no no no no no Prostate cancer Citrate cycle (TCA cycle) -0.586956522 -0.75 0 kegg kegg NA NA no no no no no no Prostate cancer Collecting duct acid secretion 0 -0.540513834 -0.47027027 kegg kegg NA NA no no no no no no Prostate cancer Collinsella 0 0 -0.40004125 kegg Genus NA 0.128 no no no no no no Prostate cancer Colorectal cancer 0.665217391 0 0.465379665 kegg kegg NA NA no no no no no no Prostate cancer Cysteine and methionine metabolism 0 -0.701581028 0 kegg kegg NA NA no no no no no no Prostate cancer Cytokine-cytokine receptor interaction 0 0 -0.468211068 kegg kegg NA NA no no no no no no Prostate cancer Cytosolic DNA-sensing pathway 0 0.850790514 0.541827542 kegg kegg NA NA no no no no no no Prostate cancer DNA replication 0 -0.716403162 0 kegg kegg NA NA no no no no no no Prostate cancer Dopaminergic synapse 0 -0.56027668 0 kegg kegg NA NA no no no no up no Prostate cancer Drug metabolism - cytochrome P450 -0.414782609 -0.751976285 0 kegg kegg NA NA no no no no no no Prostate cancer Drug metabolism - other enzymes -0.696521739 -0.663043478 0 kegg kegg NA NA no no no no no no Prostate cancer ECM-receptor interaction 0 -0.425889328 0 kegg kegg NA NA no no no no up up Prostate cancer Endometrial cancer 0.82173913 0.875494071 0.691377091 kegg kegg NA NA no no no no no no Prostate cancer Epithelial cell signaling in Helicobacter pylori infection 0.429565217 0.693675889 0.486486486 kegg kegg NA NA no no no no no no Prostate cancer ErbB signaling pathway 0.714782609 0.659090909 0.469498069 kegg kegg NA NA no no no no no no Prostate cancer Estrogen signaling pathway 0 -0.815217391 -0.457915058 kegg kegg NA NA no no no no no no Prostate cancer Ether lipid metabolism 0 -0.419960474 0 kegg kegg NA NA no no no no no no Prostate cancer Fatty acid biosynthesis 0 0.453557312 0 kegg kegg NA NA no no no no no no Prostate cancer Fatty acid elongation -0.62 -0.597826087 -0.652252252 kegg kegg NA NA no no no no no no Prostate cancer Fatty acid metabolism 0 0 -0.401544402 kegg kegg NA NA no no no no no no Prostate cancer Fc epsilon RI signaling pathway 0.52 0.679841897 0 kegg kegg NA NA no no no no no no Prostate cancer Focal adhesion -0.42 -0.615612648 -0.494208494 kegg kegg NA NA no no no no up up Prostate cancer Fructose and mannose metabolism -0.450434783 0 0 kegg kegg NA NA no no no no no no Prostate cancer Galactose metabolism -0.463478261 0 0 kegg kegg NA NA no no no no no no Prostate cancer Gastric acid secretion -0.506086957 -0.617588933 -0.456628057 kegg kegg NA NA no no no no no no Prostate cancer Glioma 0.553043478 0 0 kegg kegg NA NA no no no no no no Prostate cancer Glucagon signaling pathway 0 -0.5 0 kegg kegg NA NA no no no no no no Prostate cancer Glutathione metabolism -0.511304348 -0.514822134 -0.442471042 kegg kegg NA NA no no no no no no Prostate cancer "Glycine, serine and threonine metabolism" -0.457391304 0 0 kegg kegg NA NA no no no no up no Prostate cancer Glycolysis / Gluconeogenesis -0.643478261 -0.590909091 -0.611840412 kegg kegg NA NA no no no no no no Prostate cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.708498024 0 kegg kegg NA NA no no no no no no Prostate cancer Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.487826087 0 0 kegg kegg NA NA no no no no no no Prostate cancer Glycosphingolipid biosynthesis - ganglio series 0 -0.457509881 0 kegg kegg NA NA no no no no no no Prostate cancer Glycosphingolipid biosynthesis - lacto and neolacto series 0.52173913 0.526679842 0.52020592 kegg kegg NA NA no no no no no no Prostate cancer Glyoxylate and dicarboxylate metabolism 0 0.496047431 0 kegg kegg NA NA no no no no no no Prostate cancer GnRH secretion 0.692173913 0.68972332 0.40952381 kegg kegg NA NA no no no no up up Prostate cancer "Growth hormone synthesis, secretion and action" 0.415652174 0 0.446332046 kegg kegg NA NA no no no no no no Prostate cancer Hematopoietic cell lineage -0.439130435 -0.444664032 -0.547490347 kegg kegg NA NA no no no no no no Prostate cancer Hepatitis B 0.793043478 0.787549407 0.863063063 kegg kegg NA NA no no no no no no Prostate cancer Hepatitis C 0.744347826 0.880434783 0.837065637 kegg kegg NA NA no no no no no no Prostate cancer Hippo signaling pathway -0.468695652 -0.540513834 -0.456113256 kegg kegg NA NA no no no no no no Prostate cancer Hippo signaling pathway - multiple species 0 0.446640316 0 kegg kegg NA NA no no no no no no Prostate cancer Histidine metabolism -0.486956522 0 -0.494723295 kegg kegg NA NA no no no no no no Prostate cancer Human papillomavirus infection 0 0.604743083 0 kegg kegg NA NA no no no no no no Prostate cancer Inflammatory mediator regulation of TRP channels 0 -0.526679842 0 kegg kegg NA NA no no no no no no Prostate cancer Insulin resistance 0.834782609 0.900197628 0.873616474 kegg kegg NA NA no no no no no no Prostate cancer JAK-STAT signaling pathway 0 0.600790514 0 kegg kegg NA NA no no no no no no Prostate cancer Kaposi sarcoma-associated herpesvirus infection 0.43826087 0 0 kegg kegg NA NA no no no no no dn Prostate cancer Lachnospira 0 -0.463553263 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Prostate cancer Long-term potentiation 0 -0.551383399 0 kegg kegg NA NA no no no no no up Prostate cancer Longevity regulating pathway - multiple species 0 0 -0.609009009 kegg kegg NA NA no no no no no no Prostate cancer Lysine degradation 0.497391304 0 0 kegg kegg NA NA no no no no no no Prostate cancer Malaria 0 0.416996047 0 kegg kegg NA NA no no no no no no Prostate cancer Mannose type O-glycan biosynthesis 0.602608696 0 0 kegg kegg NA NA no no no no no no Prostate cancer Measles 0.52 0 0 kegg kegg NA NA no no no no no no Prostate cancer Melanogenesis 0 -0.437747036 0 kegg kegg NA NA no no no no no no Prostate cancer Metabolism of xenobiotics by cytochrome P450 -0.525217391 -0.77173913 -0.44015444 kegg kegg NA NA no no no no no no Prostate cancer MicroRNAs in cancer 0.573043478 0.867588933 0.523037323 kegg kegg NA NA no no no no no no Prostate cancer Mismatch repair -0.454782609 -0.787549407 -0.483655084 kegg kegg NA NA no no no no no no Prostate cancer mRNA surveillance pathway 0.58173913 0 0 kegg kegg NA NA no no no no no no Prostate cancer N-Glycan biosynthesis 0 -0.503952569 0 kegg kegg NA NA no no no no no no Prostate cancer Natural killer cell mediated cytotoxicity 0 0.454545455 0 kegg kegg NA NA no no no no no no Prostate cancer Neurotrophin signaling pathway 0.910434783 0.961462451 0.890862291 kegg kegg NA NA no no no no no no Prostate cancer NF-kappa B signaling pathway 0.517391304 0.83201581 0.789446589 kegg kegg NA NA no no no no no no Prostate cancer Nicotinate and nicotinamide metabolism 0 0.464426877 0 kegg kegg NA NA no no no no no no Prostate cancer Nicotine addiction 0 0 0.579150579 kegg kegg NA NA no no no no up up Prostate cancer Nitrogen metabolism 0 0.488142292 0 kegg kegg NA NA no no no no no no Prostate cancer NOD-like receptor signaling pathway 0 0.735177866 0 kegg kegg NA NA no no no no no no Prostate cancer Non-alcoholic fatty liver disease 0.42 0 0 kegg kegg NA NA no no no no no no Prostate cancer Non-homologous end-joining -0.62 -0.709486166 -0.680823681 kegg kegg NA NA no no no no no no Prostate cancer Notch signaling pathway 0.450434783 0.440711462 0 kegg kegg NA NA no no no no no no Prostate cancer Nucleotide excision repair 0 -0.750988142 0 kegg kegg NA NA no no no no no no Prostate cancer One carbon pool by folate 0 -0.744071146 0 kegg kegg NA NA no no no no no no Prostate cancer Oocyte meiosis 0 -0.658102767 0 kegg kegg NA NA no no no no no no Prostate cancer Osteoclast differentiation 0 0.588932806 0 kegg kegg NA NA no no no no no no Prostate cancer Other types of O-glycan biosynthesis 0.445217391 0 0 kegg kegg NA NA no no no no no no Prostate cancer Oxidative phosphorylation 0 -0.414031621 0 kegg kegg NA NA no no no no no no Prostate cancer Oxytocin signaling pathway -0.545217391 -0.450592885 -0.543371943 kegg kegg NA NA no no no no no no Prostate cancer p53 signaling pathway 0.446956522 0 0 kegg kegg NA NA no no no no no no Prostate cancer Pancreatic cancer 0.516521739 0 0 kegg kegg NA NA no no no no no no Prostate cancer Paraprevotella -0.457286941 0 0 kegg Genus NA 0.118 no no no no no no Prostate cancer "Parathyroid hormone synthesis, secretion and action" 0.433043478 0 0 kegg kegg NA NA no no no no no no Prostate cancer Pathways in cancer 0.629565217 0.636363636 0.528700129 kegg kegg NA NA no no no no no no Prostate cancer Pentose and glucuronate interconversions -0.566086957 -0.636363636 0 kegg kegg NA NA no no no no no no Prostate cancer Phenylalanine metabolism -0.751304348 -0.745059289 -0.50990991 kegg kegg NA NA no no no no no no Prostate cancer Phosphatidylinositol signaling system 0.450434783 0 0 kegg kegg NA NA no no no no no no Prostate cancer Phospholipase D signaling pathway 0 0.604743083 0 kegg kegg NA NA no no no no up up Prostate cancer Phototransduction 0 -0.697628458 0 kegg kegg NA NA no no no no no no Prostate cancer Platelet activation -0.54 -0.555335968 0 kegg kegg NA NA no no no no no no Prostate cancer Porphyrin and chlorophyll metabolism -0.483478261 0 0 kegg kegg NA NA no no no no no no Prostate cancer PPAR signaling pathway 0 0.648221344 0 kegg kegg NA NA no no no no no no Prostate cancer Primary bile acid biosynthesis -0.566956522 -0.716403162 -0.620592021 kegg kegg NA NA no no no no no no Prostate cancer Prion disease 0 -0.462450593 0 kegg kegg NA NA no no no no no no Prostate cancer Progesterone-mediated oocyte maturation 0.505217391 0 0 kegg kegg NA NA no no no no no no Prostate cancer Prolactin signaling pathway 0.48173913 0.677865613 0.468468468 kegg kegg NA NA no no no no no no Prostate cancer Propanoate metabolism -0.407826087 -0.685770751 0 kegg kegg NA NA no no no no no no Prostate cancer Proteasome 0 -0.595849802 0 kegg kegg NA NA no no no no no no Prostate cancer Protein export 0 -0.461462451 0 kegg kegg NA NA no no no no no no Prostate cancer Protein processing in endoplasmic reticulum 0 -0.450592885 0 kegg kegg NA NA no no no no no no Prostate cancer Proximal tubule bicarbonate reclamation 0 -0.653162055 0 kegg kegg NA NA no no no no no no Prostate cancer Pyramidobacter 0 0 0.443003009 kegg Genus NA 0.45 no no no no no no Prostate cancer Pyrimidine metabolism -0.612173913 -0.72826087 0 kegg kegg NA NA no no no no no no Prostate cancer Pyruvate metabolism -0.487826087 -0.704545455 -0.518404118 kegg kegg NA NA no no no no no no Prostate cancer Ras signaling pathway 0 -0.524703557 0 yes kegg kegg NA NA no no no no up up Prostate cancer Regulation of actin cytoskeleton -0.45826087 -0.654150198 -0.574774775 kegg kegg NA NA no no no no no no Prostate cancer Relaxin signaling pathway 0.665217391 0.774703557 0.649163449 kegg kegg NA NA no no no no no no Prostate cancer Renal cell carcinoma 0.634782609 0 0 kegg kegg NA NA no no no no no no Prostate cancer Renin secretion -0.406956522 -0.666007905 0 kegg kegg NA NA no no no no no no Prostate cancer Retinol metabolism -0.585217391 -0.747035573 0 kegg kegg NA NA no no no no no no Prostate cancer Retrograde endocannabinoid signaling 0 -0.526679842 0 kegg kegg NA NA no no no no no up Prostate cancer Ribosome biogenesis in eukaryotes 0 -0.475296443 0 kegg kegg NA NA no no no no no no Prostate cancer RIG-I-like receptor signaling pathway 0.73826087 0.852766798 0.853539254 kegg kegg NA NA no no no no no no Prostate cancer RNA degradation 0.545217391 0 0 kegg kegg NA NA no no no no no no Prostate cancer RNA polymerase 0 -0.48715415 0 kegg kegg NA NA no no no no no no Prostate cancer Roseburia -0.589565217 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no Prostate cancer Salivary secretion 0 -0.494071146 0 kegg kegg NA NA no no no no no no Prostate cancer Sarcina 0 0.422326513 0 kegg Genus NA 0.0703 no no no no no no Prostate cancer Signaling pathways regulating pluripotency of stem cells 0.747826087 0.481225296 0.401544402 kegg kegg NA NA no no no no no no Prostate cancer SNARE interactions in vesicular transport 0 0.517786561 0 kegg kegg NA NA no no no no no no Prostate cancer Sphingolipid signaling pathway 0.620869565 0.628458498 0 kegg kegg NA NA no no no no no no Prostate cancer Spinocerebellar ataxia 0.643478261 0 0 kegg kegg NA NA no no no no no no Prostate cancer Steroid biosynthesis 0 -0.850790514 -0.498069498 kegg kegg NA NA no no no no no no Prostate cancer Steroid hormone biosynthesis -0.595652174 -0.814229249 0 kegg kegg NA NA no no no no no no Prostate cancer Sulfur metabolism -0.48 -0.493083004 0 kegg kegg NA NA no no no no no no Prostate cancer Synthesis and degradation of ketone bodies -0.444347826 -0.755928854 -0.460746461 kegg kegg NA NA no no no no no no Prostate cancer T cell receptor signaling pathway 0.635652174 0.682806324 0 kegg kegg NA NA no no no no no no Prostate cancer Taste transduction 0 -0.658102767 0 kegg kegg NA NA no no no no no up Prostate cancer Taurine and hypotaurine metabolism 0 0.5 0.434749035 kegg kegg NA NA no no no no no no Prostate cancer Terpenoid backbone biosynthesis 0 -0.482213439 0 kegg kegg NA NA no no no no no no Prostate cancer TGF-beta signaling pathway 0 -0.455533597 0 kegg kegg NA NA no no no no no no Prostate cancer Th1 and Th2 cell differentiation 0 0.533596838 0 kegg kegg NA NA no no no no no no Prostate cancer Th17 cell differentiation 0 0.612648221 0 kegg kegg NA NA no no no no no no Prostate cancer Thermogenesis 0 -0.464426877 0 kegg kegg NA NA no no no no no no Prostate cancer Thiamine metabolism 0 -0.508893281 0 kegg kegg NA NA no no no no no no Prostate cancer Tight junction -0.489565217 -0.567193676 -0.652252252 kegg kegg NA NA no no no no no no Prostate cancer TNF signaling pathway 0.844347826 0.959486166 0.792277992 kegg kegg NA NA no no no no no no Prostate cancer Toll-like receptor signaling pathway 0.665217391 0.821146245 0.614671815 yes kegg kegg NA NA no no no no no no Prostate cancer Toxoplasmosis 0 0 -0.421364221 kegg kegg NA NA no no no no no no Prostate cancer Transcriptional misregulation in cancer 0.699130435 0.712450593 0.731531532 kegg kegg NA NA no no no no no no Prostate cancer Tryptophan metabolism -0.68173913 -0.760869565 -0.451737452 kegg kegg NA NA no no no no up no Prostate cancer Type II diabetes mellitus 0.759130435 0.710474308 0.405148005 kegg kegg NA NA no no no no no no Prostate cancer Tyrosine metabolism -0.840869565 -0.878458498 -0.809009009 kegg kegg NA NA no no no no no no Prostate cancer Ubiquinone and other terpenoid-quinone biosynthesis -0.604347826 -0.760869565 0 kegg kegg NA NA no no no no no no Prostate cancer "Valine, leucine and isoleucine degradation" -0.573913043 -0.767786561 -0.564221364 kegg kegg NA NA no no no no no no Prostate cancer Vascular smooth muscle contraction 0 -0.56027668 0 kegg kegg NA NA no no no no no no Prostate cancer Vasopressin-regulated water reabsorption 0 -0.446640316 0 kegg kegg NA NA no no no no no no Prostate cancer VEGF signaling pathway 0.72 0.661067194 0.41956242 kegg kegg NA NA no no no no no no Prostate cancer Vibrio cholerae infection -0.486956522 -0.539525692 0 kegg kegg NA NA no no no no no no Prostate cancer Viral carcinogenesis 0 0.671936759 0.423938224 kegg kegg NA NA no no no no no no Proteasome 2-Oxocarboxylic acid metabolism 0 0.612648221 0.490862291 kegg kegg NA NA no no no no no no Proteasome ABC transporters 0 -0.447628458 0 kegg kegg NA NA no no no no up up Proteasome "Alanine, aspartate and glutamate metabolism" 0 -0.603754941 0 kegg kegg NA NA no no no no no no Proteasome alpha-Linolenic acid metabolism 0 -0.434782609 0 kegg kegg NA NA no no no no no no Proteasome Antifolate resistance -0.424347826 0 0 kegg kegg NA NA no no no no no no Proteasome Arginine and proline metabolism 0 -0.615612648 0 kegg kegg NA NA no no no no up no Proteasome Arginine biosynthesis 0 -0.590909091 0 kegg kegg NA NA no no no no no no Proteasome Ascorbate and aldarate metabolism 0 0.489130435 0.411840412 kegg kegg NA NA no no no no no no Proteasome Basal transcription factors 0.499130435 0 0 kegg kegg NA NA no no no no no no Proteasome beta-Alanine metabolism 0 0.543478261 0 kegg kegg NA NA no no no no no no Proteasome Bifidobacterium 0 0.482418517 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Proteasome Biosynthesis of unsaturated fatty acids 0 0.459486166 0 kegg kegg NA NA no no no no no no Proteasome Butanoate metabolism 0 0.700592885 0 kegg kegg NA NA no no no no no no Proteasome Carbon metabolism 0 0.533596838 0 kegg kegg NA NA no no no no no no Proteasome Citrate cycle (TCA cycle) 0 0.815217391 0.673101673 kegg kegg NA NA no no no no no no Proteasome Clostridium 0 0.606189257 0 kegg Genus NA 0.925 no no no no no no Proteasome Cysteine and methionine metabolism 0 0.740118577 0 kegg kegg NA NA no no no no no no Proteasome DNA replication 0 0.611660079 0.458687259 kegg kegg NA NA no no no no no no Proteasome Drug metabolism - cytochrome P450 0 0.731225296 0.41029601 kegg kegg NA NA no no no no no no Proteasome Drug metabolism - other enzymes 0 0.812252964 0.573487773 kegg kegg NA NA no no no no no no Proteasome EGFR tyrosine kinase inhibitor resistance 0.412173913 0.490118577 0.501930502 kegg kegg NA NA no no no no no no Proteasome Endocrine resistance 0 -0.485177866 -0.736679537 kegg kegg NA NA no no no no no no Proteasome Fatty acid biosynthesis 0 -0.631422925 0 kegg kegg NA NA no no no no no no Proteasome Fatty acid degradation 0 0 0.445817246 kegg kegg NA NA no no no no no no Proteasome Fatty acid elongation 0 0.565217391 0 kegg kegg NA NA no no no no no no Proteasome Folate biosynthesis 0 0.498023715 0 kegg kegg NA NA no no no no no no Proteasome Fructose and mannose metabolism 0 -0.505928854 0 kegg kegg NA NA no no no no no no Proteasome Glycerolipid metabolism 0 -0.551383399 0 kegg kegg NA NA no no no no no up Proteasome Glycerophospholipid metabolism 0 -0.497035573 0 kegg kegg NA NA no no no no no up Proteasome Glycolysis / Gluconeogenesis 0 0.804347826 0 kegg kegg NA NA no no no no no no Proteasome Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.818181818 0 kegg kegg NA NA no no no no no no Proteasome Glyoxylate and dicarboxylate metabolism 0 -0.554347826 0 kegg kegg NA NA no no no no no no Proteasome Inositol phosphate metabolism 0 -0.422924901 0 kegg kegg NA NA no no no no no no Proteasome Lachnospira -0.494782609 0.447244886 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Proteasome Metabolism of xenobiotics by cytochrome P450 0 0.767786561 0.408751609 kegg kegg NA NA no no no no no no Proteasome N-Glycan biosynthesis 0 0.575098814 0 kegg kegg NA NA no no no no no no Proteasome Nicotinate and nicotinamide metabolism 0 -0.643280632 0 kegg kegg NA NA no no no no no no Proteasome Nitrogen metabolism 0 -0.622529644 0 kegg kegg NA NA no no no no no no Proteasome Odoribacter 0 0.443290116 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Proteasome One carbon pool by folate 0 0.427865613 0 kegg kegg NA NA no no no no no no Proteasome Oxidative phosphorylation 0 0.502964427 0 kegg kegg NA NA no no no no no no Proteasome Pentose and glucuronate interconversions 0 0.745059289 0 kegg kegg NA NA no no no no no no Proteasome Phenylalanine metabolism 0 0.606719368 0 kegg kegg NA NA no no no no no no Proteasome Prevotella 0 -0.477819767 -0.453503785 acetate-producing kegg Genus NA 0.287 no no no no no no Proteasome Primary bile acid biosynthesis 0 0.686758893 0 kegg kegg NA NA no no no no no no Proteasome Propanoate metabolism 0 0.731225296 0 kegg kegg NA NA no no no no no no Proteasome Pyrimidine metabolism 0 0.475296443 0 kegg kegg NA NA no no no no no no Proteasome Pyruvate metabolism 0 0.741106719 0 kegg kegg NA NA no no no no no no Proteasome Retinol metabolism 0 0 0.43963964 kegg kegg NA NA no no no no no no Proteasome Ribosome 0 0.532608696 0.433719434 kegg kegg NA NA no no no no no no Proteasome RNA degradation 0.433913043 0.5 0 kegg kegg NA NA no no no no no no Proteasome RNA polymerase 0 0.442687747 0 kegg kegg NA NA no no no no no no Proteasome RNA transport 0 0.535573123 0 kegg kegg NA NA no no no no no no Proteasome Ruminococcus 0.413155627 0 0 kegg Genus NA 0.0679 no no no no no dn Proteasome Starch and sucrose metabolism 0 -0.485177866 0 kegg kegg NA NA no no no no no no Proteasome Steroid biosynthesis 0 0.633399209 0 kegg kegg NA NA no no no no no no Proteasome Steroid hormone biosynthesis 0 0.437747036 0 kegg kegg NA NA no no no no no no Proteasome Sulfur metabolism 0 0.451581028 0 kegg kegg NA NA no no no no no no Proteasome Synthesis and degradation of ketone bodies 0 0.540513834 0 kegg kegg NA NA no no no no no no Proteasome Taurine and hypotaurine metabolism 0 -0.714426877 0 kegg kegg NA NA no no no no no no Proteasome Terpenoid backbone biosynthesis 0 0.467391304 0 kegg kegg NA NA no no no no no no Proteasome Thiamine metabolism 0 0.541501976 0 kegg kegg NA NA no no no no no no Proteasome Tryptophan metabolism 0 0.722332016 0.487773488 kegg kegg NA NA no no no no up no Proteasome Tyrosine metabolism 0 0.530632411 0 kegg kegg NA NA no no no no no no Proteasome Ubiquinone and other terpenoid-quinone biosynthesis 0 0.490118577 0 kegg kegg NA NA no no no no no no Proteasome "Valine, leucine and isoleucine degradation" 0 0.625494071 0 kegg kegg NA NA no no no no no no Proteasome Various types of N-glycan biosynthesis 0 0.526679842 0 kegg kegg NA NA no no no no no no Protein digestion and absorption Adherens junction 0 -0.540513834 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Adrenergic signaling in cardiomyocytes -0.635652174 -0.734189723 0 yes kegg kegg NA NA no up up no no up Protein digestion and absorption AGE-RAGE signaling pathway in diabetic complications 0.57826087 0.643280632 0.552123552 yes kegg kegg NA NA no up up no no no Protein digestion and absorption "Alanine, aspartate and glutamate metabolism" 0.576521739 0.564229249 0.438095238 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Aldosterone synthesis and secretion -0.54173913 -0.750988142 -0.406949807 yes kegg kegg NA NA no up up no up up Protein digestion and absorption Aldosterone-regulated sodium reabsorption 0 0 0.771428571 yes kegg kegg NA NA no up up no no no Protein digestion and absorption alpha-Linolenic acid metabolism 0.52 0.542490119 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Aminoacyl-tRNA biosynthesis 0.512173913 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption AMPK signaling pathway 0 -0.462450593 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Apelin signaling pathway 0 -0.645256917 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Apoptosis 0 0.564229249 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Apoptosis - multiple species 0.432173913 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Arginine and proline metabolism 0 0.595849802 0 yes kegg kegg NA NA no up up no up no Protein digestion and absorption Arginine biosynthesis 0.565217391 0.490118577 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Autophagy - animal 0 0.606719368 0.688803089 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Axon guidance -0.443478261 0 0 yes kegg kegg NA NA no up up no up up Protein digestion and absorption B cell receptor signaling pathway 0 0.540513834 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption beta-Alanine metabolism 0.574782609 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Biosynthesis of amino acids 0.474782609 0.561264822 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Biosynthesis of cofactors 0 -0.423913043 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Biosynthesis of unsaturated fatty acids 0.429565217 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption C-type lectin receptor signaling pathway 0 0.593873518 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Calcium signaling pathway -0.514782609 -0.735177866 0 yes kegg kegg NA NA no up up no up up Protein digestion and absorption cAMP signaling pathway -0.659130435 0 0 yes yes kegg kegg NA NA no up up no up up Protein digestion and absorption Carbohydrate digestion and absorption 0 0 0.673101673 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Carbon metabolism 0.416521739 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Cardiac muscle contraction -0.652173913 -0.835968379 -0.402316602 yes kegg kegg NA NA no up up no no up Protein digestion and absorption Cell adhesion molecules 0.431304348 0.526679842 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Cellular senescence 0 0.47826087 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption cGMP-PKG signaling pathway 0 0.606719368 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Circadian entrainment -0.551304348 -0.579051383 -0.547747748 yes kegg kegg NA NA no up up no up up Protein digestion and absorption Circadian rhythm -0.470434783 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Complement and coagulation cascades 0 0.513833992 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Cortisol synthesis and secretion -0.506086957 -0.516798419 0 yes kegg kegg NA NA no up up no no up Protein digestion and absorption Cushing syndrome -0.495652174 -0.53458498 0 yes kegg kegg NA NA no up up no no up Protein digestion and absorption Cytosolic DNA-sensing pathway -0.528695652 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Dopaminergic synapse -0.693913043 -0.722332016 -0.474131274 yes kegg kegg NA NA no up up no up no Protein digestion and absorption Drug metabolism - cytochrome P450 0 -0.418972332 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption EGFR tyrosine kinase inhibitor resistance 0 -0.553359684 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Endocrine and other factor-regulated calcium reabsorption -0.515652174 -0.848814229 -0.423938224 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Endocytosis 0 0.543478261 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption ErbB signaling pathway 0 0 0.453796654 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Ether lipid metabolism -0.589565217 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Fatty acid biosynthesis 0.546956522 0.625494071 0.455598456 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Fatty acid degradation 0.713913043 0.750988142 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Fatty acid metabolism 0.743478261 0.726284585 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Fc epsilon RI signaling pathway 0 0.656126482 0.586872587 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Fc gamma R-mediated phagocytosis 0.485217391 0.664031621 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Focal adhesion 0 -0.425889328 0 yes kegg kegg NA NA no up up no up up Protein digestion and absorption FoxO signaling pathway 0 0.610671937 0.438352638 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Fructose and mannose metabolism 0 0.477272727 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Galactose metabolism 0.553043478 0.628458498 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Gastric acid secretion 0 -0.641304348 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Glucagon signaling pathway -0.431304348 -0.719367589 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Glutathione metabolism 0 -0.732213439 -0.41029601 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Glycerolipid metabolism 0 0.463438735 0 yes kegg kegg NA NA no up up no no up Protein digestion and absorption "Glycine, serine and threonine metabolism" 0 -0.462450593 0 yes kegg kegg NA NA no up up no up no Protein digestion and absorption Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.612648221 0.422136422 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Glycosaminoglycan biosynthesis - keratan sulfate -0.41826087 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Glycosaminoglycan degradation 0 0.564229249 0.409009009 yes kegg kegg NA NA no up up no no up Protein digestion and absorption Glyoxylate and dicarboxylate metabolism 0.682608696 0.524703557 0.412097812 yes kegg kegg NA NA no up up no no no Protein digestion and absorption GnRH secretion 0 0 0.415701416 yes kegg kegg NA NA no up up no up up Protein digestion and absorption GnRH signaling pathway -0.453043478 -0.502964427 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Hematopoietic cell lineage 0.684347826 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption HIF-1 signaling pathway 0 -0.500988142 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Hippo signaling pathway 0 -0.479249012 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Hippo signaling pathway - multiple species 0 0.635375494 0.49009009 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Histidine metabolism 0.511304348 0.424901186 0.407207207 yes kegg kegg NA NA no up up no no no Protein digestion and absorption IL-17 signaling pathway 0 0.555335968 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Inflammatory mediator regulation of TRP channels -0.479130435 -0.670948617 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Inositol phosphate metabolism 0.42 0.446640316 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Insulin secretion 0 -0.593873518 0 yes yes kegg kegg NA NA no up up no up up Protein digestion and absorption Insulin signaling pathway 0 -0.566205534 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption JAK-STAT signaling pathway 0 0.561264822 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Linoleic acid metabolism 0 -0.51284585 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Long-term depression -0.53826087 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Lysosome 0 0.483201581 0.442728443 yes kegg kegg NA NA no up up no no no Protein digestion and absorption MAPK signaling pathway 0 0.580039526 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Melanogenesis -0.504347826 -0.750988142 -0.417760618 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Mitophagy - animal -0.651304348 -0.805335968 -0.409009009 yes kegg kegg NA NA no up up no no no Protein digestion and absorption mRNA surveillance pathway -0.46 -0.489130435 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption mTOR signaling pathway 0 -0.52173913 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Mucin type O-glycan biosynthesis 0 0.458498024 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption N-Glycan biosynthesis 0 -0.438735178 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Natural killer cell mediated cytotoxicity 0 0.494071146 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Necroptosis 0 -0.429841897 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Neuroactive ligand-receptor interaction 0 0.575098814 0 yes kegg kegg NA NA no up up up up up Protein digestion and absorption Neurotrophin signaling pathway -0.439130435 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Neutrophil extracellular trap formation 0 0.505928854 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption NF-kappa B signaling pathway 0.428695652 0.56027668 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Nicotinate and nicotinamide metabolism 0.544347826 0.614624506 0.438867439 yes kegg kegg NA NA no up up no no no Protein digestion and absorption NOD-like receptor signaling pathway 0.496521739 0.757905138 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Non-alcoholic fatty liver disease -0.668695652 -0.79743083 -0.5001287 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Non-homologous end-joining 0.506956522 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Olfactory transduction 0 0.515810277 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Osteoclast differentiation 0 0.739130435 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Other glycan degradation 0 0.483201581 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Ovarian steroidogenesis -0.443478261 -0.520750988 0 yes kegg kegg NA NA no up up no up up Protein digestion and absorption Oxidative phosphorylation -0.643478261 -0.839920949 -0.468211068 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Pancreatic secretion -0.687826087 -0.751976285 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Pantothenate and CoA biosynthesis 0.417391304 0.716403162 0.546975547 yes kegg kegg NA NA no up up no no dn Protein digestion and absorption "Parathyroid hormone synthesis, secretion and action" -0.747826087 -0.694664032 -0.442471042 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Pentose phosphate pathway 0 0.567193676 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Peroxisome 0.669565217 0.643280632 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Phagosome 0.423478261 0.5 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Phototransduction 0 0 -0.405662806 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Platelet activation 0 -0.479249012 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Porphyrin and chlorophyll metabolism 0 -0.46541502 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption PPAR signaling pathway 0 0.592885375 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Prolactin signaling pathway 0 0.640316206 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Protein export 0 -0.51284585 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Protein processing in endoplasmic reticulum 0 -0.5256917 -0.432432432 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Proximal tubule bicarbonate reclamation 0 -0.471343874 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Purine metabolism 0 -0.529644269 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Pyrimidine metabolism 0.575652174 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Pyruvate metabolism 0 -0.449604743 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Ras signaling pathway 0 -0.443675889 0 yes yes kegg kegg NA NA no up up no up up Protein digestion and absorption Regulation of actin cytoskeleton 0 0 -0.411583012 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Regulation of lipolysis in adipocytes -0.525217391 -0.575098814 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Relaxin signaling pathway -0.70173913 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Renin secretion -0.496521739 -0.713438735 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Renin-angiotensin system 0 0.666996047 0.496267696 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Retinol metabolism 0.408695652 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Retrograde endocannabinoid signaling -0.599130435 -0.873517787 0 yes kegg kegg NA NA no up up no no up Protein digestion and absorption Ribosome -0.524347826 -0.731225296 -0.522007722 yes kegg kegg NA NA no up up no no no Protein digestion and absorption RIG-I-like receptor signaling pathway 0 0.541501976 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption RNA degradation -0.439130435 -0.492094862 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption RNA polymerase 0 -0.444664032 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Serotonergic synapse -0.489565217 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption SNARE interactions in vesicular transport 0 0.585968379 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Sphingolipid metabolism 0 0 0.40952381 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Sphingolipid signaling pathway 0 0.436758893 0.406177606 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Starch and sucrose metabolism 0 0.711462451 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Synaptic vesicle cycle 0 0.497035573 0 yes kegg kegg NA NA no up up no up up Protein digestion and absorption TGF-beta signaling pathway -0.446956522 -0.462450593 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Th1 and Th2 cell differentiation 0 0.537549407 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Th17 cell differentiation 0 0.56027668 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Thermogenesis -0.666956522 -0.835968379 -0.56036036 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Thyroid hormone signaling pathway 0 -0.57312253 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Thyroid hormone synthesis -0.409565217 -0.714426877 -0.407207207 yes kegg kegg NA NA no up up no no no Protein digestion and absorption TNF signaling pathway 0 0.448616601 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Toll-like receptor signaling pathway 0 0.576086957 0 yes yes kegg kegg NA NA no up up no no no Protein digestion and absorption Tryptophan metabolism 0.491304348 0 0 yes kegg kegg NA NA no up up no up no Protein digestion and absorption Type I diabetes mellitus 0.426086957 0.469367589 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Type II diabetes mellitus 0 0.493083004 0.574517375 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Ubiquitin mediated proteolysis -0.645217391 -0.807312253 -0.433462033 yes kegg kegg NA NA no up up no no no Protein digestion and absorption "Valine, leucine and isoleucine degradation" 0.406086957 0 0 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Vascular smooth muscle contraction -0.770434783 -0.773715415 -0.518661519 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Vasopressin-regulated water reabsorption -0.586086957 -0.817193676 -0.511454311 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Viral protein interaction with cytokine and cytokine receptor 0 0 -0.487258687 yes kegg kegg NA NA no up up no no no Protein digestion and absorption Wnt signaling pathway -0.52 -0.523715415 0 yes kegg kegg NA NA no up up no no no Protein export 2-Oxocarboxylic acid metabolism 0 0.62944664 0 kegg kegg NA NA no no no no no no Protein export ABC transporters 0 -0.425889328 0 kegg kegg NA NA no no no no up up Protein export "Alanine, aspartate and glutamate metabolism" -0.416521739 -0.837944664 -0.651994852 kegg kegg NA NA no no no no no no Protein export alpha-Linolenic acid metabolism -0.533913043 -0.772727273 0 kegg kegg NA NA no no no no no no Protein export Arachidonic acid metabolism 0 0 -0.577863578 kegg kegg NA NA no no no no no no Protein export Arginine and proline metabolism -0.448695652 -0.738142292 -0.490862291 kegg kegg NA NA no no no no up no Protein export Arginine biosynthesis -0.528695652 -0.81916996 -0.71016731 kegg kegg NA NA no no no no no no Protein export Ascorbate and aldarate metabolism 0 0.475296443 0 kegg kegg NA NA no no no no no no Protein export Basal transcription factors 0.817391304 0.458498024 0.608494208 kegg kegg NA NA no no no no no no Protein export beta-Alanine metabolism -0.435652174 0 0 kegg kegg NA NA no no no no no no Protein export Biosynthesis of amino acids -0.689565217 -0.595849802 -0.642471042 kegg kegg NA NA no no no no no no Protein export Biosynthesis of cofactors 0 0 -0.438095238 kegg kegg NA NA no no no no no no Protein export Butanoate metabolism 0 0.636363636 0 kegg kegg NA NA no no no no no no Protein export Carbon metabolism -0.465217391 0 -0.402316602 kegg kegg NA NA no no no no no no Protein export Citrate cycle (TCA cycle) 0 0.714426877 0.485971686 kegg kegg NA NA no no no no no no Protein export Cysteine and methionine metabolism 0 0.706521739 0.503217503 kegg kegg NA NA no no no no no no Protein export DNA replication 0.583478261 0.638339921 0.545945946 kegg kegg NA NA no no no no no no Protein export Drug metabolism - cytochrome P450 0 0.706521739 0 kegg kegg NA NA no no no no no no Protein export Drug metabolism - other enzymes 0 0.800395257 0 kegg kegg NA NA no no no no no no Protein export EGFR tyrosine kinase inhibitor resistance 0.569565217 0.713438735 0.591763192 kegg kegg NA NA no no no no no no Protein export Ether lipid metabolism 0.543478261 0.496047431 0.487773488 kegg kegg NA NA no no no no no no Protein export Fatty acid biosynthesis 0 -0.897233202 0 kegg kegg NA NA no no no no no no Protein export Fatty acid degradation 0 -0.711462451 0 kegg kegg NA NA no no no no no no Protein export Fatty acid metabolism -0.444347826 -0.644268775 0 kegg kegg NA NA no no no no no no Protein export Folate biosynthesis 0 0.659090909 0 kegg kegg NA NA no no no no no no Protein export Fructose and mannose metabolism -0.519130435 -0.592885375 0 kegg kegg NA NA no no no no no no Protein export Galactose metabolism -0.608695652 -0.744071146 0 kegg kegg NA NA no no no no no no Protein export Glutathione metabolism 0 0.636363636 -0.466151866 kegg kegg NA NA no no no no no no Protein export Glycerolipid metabolism 0 -0.618577075 0 kegg kegg NA NA no no no no no up Protein export Glycerophospholipid metabolism 0 -0.443675889 0.44041184 kegg kegg NA NA no no no no no up Protein export "Glycine, serine and threonine metabolism" 0 0 -0.461776062 kegg kegg NA NA no no no no up no Protein export Glycolysis / Gluconeogenesis 0 0.618577075 0 kegg kegg NA NA no no no no no no Protein export Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.625217391 -0.834980237 0 kegg kegg NA NA no no no no no no Protein export Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.425225225 kegg kegg NA NA no no no no no no Protein export Glyoxylate and dicarboxylate metabolism -0.492173913 -0.791501976 -0.668983269 kegg kegg NA NA no no no no no no Protein export Lysine degradation 0.457391304 0 0.595624196 kegg kegg NA NA no no no no no no Protein export Mannose type O-glycan biosynthesis 0 0 0.597683398 kegg kegg NA NA no no no no no no Protein export Metabolism of xenobiotics by cytochrome P450 0 0.687747036 0 kegg kegg NA NA no no no no no no Protein export mRNA surveillance pathway 0.756521739 0.72826087 0.762676963 kegg kegg NA NA no no no no no no Protein export N-Glycan biosynthesis 0.700869565 0.774703557 0.536679537 kegg kegg NA NA no no no no no no Protein export Nicotinate and nicotinamide metabolism -0.509565217 -0.85770751 -0.509137709 kegg kegg NA NA no no no no no no Protein export Nitrogen metabolism -0.648695652 -0.759881423 -0.707335907 kegg kegg NA NA no no no no no no Protein export One carbon pool by folate 0.454782609 0.463438735 0.529472329 kegg kegg NA NA no no no no no no Protein export Other types of O-glycan biosynthesis 0.607826087 0 0.488288288 kegg kegg NA NA no no no no no no Protein export Oxidative phosphorylation 0.507826087 0.769762846 0.442213642 kegg kegg NA NA no no no no no no Protein export Pantothenate and CoA biosynthesis -0.416521739 -0.730237154 -0.412870013 kegg kegg NA NA no no no no no dn Protein export Pentose and glucuronate interconversions 0 0.805335968 0.484942085 kegg kegg NA NA no no no no no no Protein export Pentose phosphate pathway -0.806086957 -0.554347826 -0.61029601 kegg kegg NA NA no no no no no no Protein export Phenylalanine metabolism 0 0.481225296 0 kegg kegg NA NA no no no no no no Protein export Platinum drug resistance 0.434782609 0 0 kegg kegg NA NA no no no no no no Protein export Porphyrin and chlorophyll metabolism 0 0 -0.432947233 kegg kegg NA NA no no no no no no Protein export Propanoate metabolism 0 0.658102767 0.497554698 kegg kegg NA NA no no no no no no Protein export Proteasome 0.473913043 0.798418972 0 kegg kegg NA NA no no no no no no Protein export Pyrimidine metabolism 0 0.501976285 0 kegg kegg NA NA no no no no no no Protein export Pyruvate metabolism 0 0.741106719 0 kegg kegg NA NA no no no no no no Protein export Ribosome 0.680869565 0.759881423 0.529214929 kegg kegg NA NA no no no no no no Protein export Ribosome biogenesis in eukaryotes 0.744347826 0.442687747 0.652252252 kegg kegg NA NA no no no no no no Protein export RNA degradation 0.786956522 0.820158103 0.768339768 kegg kegg NA NA no no no no no no Protein export RNA polymerase 0.834782609 0.622529644 0.597425997 kegg kegg NA NA no no no no no no Protein export RNA transport 0 0.685770751 0.416216216 kegg kegg NA NA no no no no no no Protein export Selenocompound metabolism 0.510434783 0 0 kegg kegg NA NA no no no no no no Protein export Sphingolipid metabolism -0.451304348 0 0 kegg kegg NA NA no no no no no no Protein export Spliceosome 0.616521739 0 0.65019305 kegg kegg NA NA no no no no no no Protein export Starch and sucrose metabolism -0.643478261 -0.833992095 0 kegg kegg NA NA no no no no no no Protein export Steroid biosynthesis 0.693913043 0.451581028 0.418018018 kegg kegg NA NA no no no no no no Protein export Sulfur metabolism 0 0 -0.546975547 kegg kegg NA NA no no no no no no Protein export Synthesis and degradation of ketone bodies 0 0.429841897 0.431660232 kegg kegg NA NA no no no no no no Protein export Taurine and hypotaurine metabolism 0 -0.583003953 0 kegg kegg NA NA no no no no no no Protein export Terpenoid backbone biosynthesis 0.730434783 0 0.512483912 kegg kegg NA NA no no no no no no Protein export Thiamine metabolism 0 0.599802372 0 kegg kegg NA NA no no no no no no Protein export Tryptophan metabolism 0 0.490118577 0 kegg kegg NA NA no no no no up no Protein export Tyrosine metabolism 0 0.449604743 0 kegg kegg NA NA no no no no no no Protein export Ubiquinone and other terpenoid-quinone biosynthesis 0 0 0.404375804 kegg kegg NA NA no no no no no no Protein export "Valine, leucine and isoleucine degradation" 0 0.552371542 0 kegg kegg NA NA no no no no no no Protein export Various types of N-glycan biosynthesis 0.679130435 0.677865613 0.486486486 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum 2-Oxocarboxylic acid metabolism 0 0.77173913 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum "Alanine, aspartate and glutamate metabolism" -0.490434783 -0.769762846 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum alpha-Linolenic acid metabolism 0 -0.586956522 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Aminoacyl-tRNA biosynthesis 0 0.614624506 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Antifolate resistance 0 0.450592885 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Arginine and proline metabolism -0.516521739 -0.73715415 0 kegg kegg NA NA no no no no up no Protein processing in endoplasmic reticulum Arginine biosynthesis -0.53826087 -0.790513834 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Ascorbate and aldarate metabolism 0 0.494071146 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Autophagy - animal 0 -0.592885375 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Basal transcription factors 0 0.673913043 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Base excision repair 0.468695652 0.611660079 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Biosynthesis of amino acids 0 -0.757905138 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Biosynthesis of cofactors 0.511304348 0.654150198 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Butanoate metabolism 0 0.716403162 0.498069498 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Cell cycle 0.486956522 0.799407115 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum cGMP-PKG signaling pathway -0.406086957 -0.875494071 -0.484942085 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Chemokine signaling pathway -0.529565217 -0.778656126 -0.424195624 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Citrate cycle (TCA cycle) 0 0.726284585 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Cysteine and methionine metabolism 0 0.659090909 0.506563707 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Cytokine-cytokine receptor interaction 0 -0.497035573 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum DNA replication 0.479130435 0.792490119 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Drug metabolism - cytochrome P450 0 0.743083004 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Drug metabolism - other enzymes 0 0.720355731 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum EGFR tyrosine kinase inhibitor resistance 0.415652174 0.606719368 0.599485199 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Ether lipid metabolism 0 0.654150198 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Fanconi anemia pathway 0.423478261 0.56027668 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Fatty acid biosynthesis -0.606086957 -0.860671937 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Fatty acid degradation 0 -0.558300395 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Fatty acid metabolism -0.410434783 -0.602766798 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Folate biosynthesis 0 0.638339921 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum FoxO signaling pathway 0 -0.461462451 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Galactose metabolism 0 -0.596837945 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Glutathione metabolism 0.406086957 0.681818182 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum "Glycine, serine and threonine metabolism" 0.48 0.485177866 0 kegg kegg NA NA no no no no up no Protein processing in endoplasmic reticulum Glycolysis / Gluconeogenesis 0 0.415019763 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.599130435 -0.627470356 -0.512483912 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.585968379 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Glycosaminoglycan degradation -0.506956522 -0.462450593 -0.513513514 kegg kegg NA NA no no no no no up Protein processing in endoplasmic reticulum Glycosphingolipid biosynthesis - ganglio series 0 0.679841897 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Glyoxylate and dicarboxylate metabolism -0.500869565 -0.803359684 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum HIF-1 signaling pathway 0 0.537549407 0.4998713 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Lysine degradation 0 0.489130435 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Mannose type O-glycan biosynthesis 0 0.42687747 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Metabolism of xenobiotics by cytochrome P450 0 0.65513834 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Mismatch repair 0 0.60770751 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Mitophagy - animal 0.449565217 0.463438735 0.72020592 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum mRNA surveillance pathway 0 0.84486166 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum N-Glycan biosynthesis 0.597391304 0.890316206 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Neuroactive ligand-receptor interaction 0 -0.656126482 0 kegg kegg NA NA no no no up up up Protein processing in endoplasmic reticulum NF-kappa B signaling pathway -0.432173913 -0.623517787 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Nicotinate and nicotinamide metabolism -0.626956522 -0.922924901 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Nitrogen metabolism -0.472173913 -0.754940711 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Non-homologous end-joining 0 0 0.479021879 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Nucleotide excision repair 0.477391304 0.731225296 0.431145431 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum One carbon pool by folate 0.451304348 0.71541502 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Oocyte meiosis 0 0.585968379 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Other glycan degradation 0 0 -0.418790219 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Oxidative phosphorylation 0 0.598814229 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Pantothenate and CoA biosynthesis -0.568695652 -0.836956522 0 kegg kegg NA NA no no no no no dn Protein processing in endoplasmic reticulum Paraprevotella 0 0.493405267 0 kegg Genus NA 0.118 no no no no no no Protein processing in endoplasmic reticulum Pentose and glucuronate interconversions 0 0.85770751 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Pentose phosphate pathway -0.497391304 -0.824110672 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Phenylalanine metabolism 0 0.563241107 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Phospholipase D signaling pathway -0.411304348 -0.641304348 -0.475160875 kegg kegg NA NA no no no no up up Protein processing in endoplasmic reticulum Porphyrin and chlorophyll metabolism 0.499130435 0.488142292 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum PPAR signaling pathway -0.466956522 -0.697628458 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Propanoate metabolism 0 0.58201581 0.542857143 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Proteasome 0 0.549407115 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Protein export 0.606086957 0.811264822 0.423423423 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Purine metabolism 0.596521739 0.585968379 0.584298584 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Pyrimidine metabolism 0 0.682806324 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Pyruvate metabolism 0 0.726284585 0.682368082 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Ras signaling pathway 0 0.678853755 0 yes kegg kegg NA NA no no no no up up Protein processing in endoplasmic reticulum Retinol metabolism 0 0.434782609 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Ribosome 0 0.583992095 0.63963964 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Ribosome biogenesis in eukaryotes 0.506956522 0.72826087 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum RNA degradation 0 0.877470356 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum RNA polymerase 0.512173913 0.839920949 0.463063063 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum RNA transport 0 0.595849802 0.519176319 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Sphingolipid metabolism -0.457391304 0 -0.536679537 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Sphingolipid signaling pathway 0 -0.47826087 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Starch and sucrose metabolism -0.486086957 -0.818181818 -0.45045045 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Steroid biosynthesis 0.54173913 0.45256917 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Steroid hormone biosynthesis 0 0.414031621 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Sulfur metabolism 0 0.443675889 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Synthesis and degradation of ketone bodies 0 0.611660079 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Terpenoid backbone biosynthesis 0.409565217 0.527667984 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Thiamine metabolism 0 0.62055336 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Tryptophan metabolism 0 0.419960474 0 kegg kegg NA NA no no no no up no Protein processing in endoplasmic reticulum Tyrosine metabolism 0 0.584980237 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Ubiquinone and other terpenoid-quinone biosynthesis 0 0.609683794 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Ubiquitin mediated proteolysis 0.55826087 0.599802372 0.75958816 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum "Valine, leucine and isoleucine degradation" 0 0.699604743 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Various types of N-glycan biosynthesis 0.556521739 0.804347826 0 kegg kegg NA NA no no no no no no Protein processing in endoplasmic reticulum Viral protein interaction with cytokine and cytokine receptor 0 -0.517786561 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer 2-Oxocarboxylic acid metabolism 0 0.528656126 0.492406692 kegg kegg NA NA no no no no no no Proteoglycans in cancer ABC transporters 0 -0.469367589 0 kegg kegg NA NA no no no no up up Proteoglycans in cancer Adherens junction 0 0.591897233 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Adipocytokine signaling pathway 0 -0.420948617 -0.435521236 kegg kegg NA NA no no no no no no Proteoglycans in cancer Adrenergic signaling in cardiomyocytes 0 0.644268775 0 kegg kegg NA NA no no no no no up Proteoglycans in cancer African trypanosomiasis 0 -0.733201581 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer AGE-RAGE signaling pathway in diabetic complications 0 -0.748023715 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Akkermansia 0 0.420779509 0 acetate-producing kegg Genus NA 0.23 no no no no no no Proteoglycans in cancer "Alanine, aspartate and glutamate metabolism" 0 -0.727272727 -0.426512227 kegg kegg NA NA no no no no no no Proteoglycans in cancer Aldosterone synthesis and secretion 0 0.502964427 0 kegg kegg NA NA no no no no up up Proteoglycans in cancer alpha-Linolenic acid metabolism 0 -0.833003953 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Alzheimer disease 0 0.73715415 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Amino sugar and nucleotide sugar metabolism 0 -0.486166008 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Amoebiasis -0.471304348 -0.707509881 -0.458944659 kegg kegg NA NA no no no no no no Proteoglycans in cancer Amphetamine addiction 0 0.457509881 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Amyotrophic lateral sclerosis 0 0.717391304 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Apelin signaling pathway 0.716521739 0.899209486 0.815958816 kegg kegg NA NA no no no no no no Proteoglycans in cancer Apoptosis 0 -0.57312253 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Apoptosis - multiple species 0 -0.433794466 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Arachidonic acid metabolism 0 0 -0.469498069 kegg kegg NA NA no no no no no no Proteoglycans in cancer Arginine and proline metabolism 0 -0.688735178 0 kegg kegg NA NA no no no no up no Proteoglycans in cancer Arginine biosynthesis 0 -0.678853755 -0.461776062 kegg kegg NA NA no no no no no no Proteoglycans in cancer Autophagy - animal 0 -0.656126482 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer B cell receptor signaling pathway 0 -0.552371542 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Bacterial invasion of epithelial cells 0 0.440711462 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Basal transcription factors 0 0 0.410553411 kegg kegg NA NA no no no no no no Proteoglycans in cancer Base excision repair 0 0 0.411068211 kegg kegg NA NA no no no no no no Proteoglycans in cancer Bifidobacterium 0 0.511145698 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Proteoglycans in cancer Bile secretion 0 0 -0.432175032 kegg kegg NA NA no no no no no no Proteoglycans in cancer Biosynthesis of amino acids 0 -0.434782609 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Biosynthesis of cofactors 0 0 -0.542342342 kegg kegg NA NA no no no no no no Proteoglycans in cancer Butanoate metabolism 0 0.557312253 0.546203346 kegg kegg NA NA no no no no no no Proteoglycans in cancer C-type lectin receptor signaling pathway 0 -0.535573123 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Calcium signaling pathway 0 0.532608696 0 kegg kegg NA NA no no no no up up Proteoglycans in cancer Cardiac muscle contraction 0 0.739130435 0 kegg kegg NA NA no no no no no up Proteoglycans in cancer Cell cycle 0 0.450592885 0.423423423 kegg kegg NA NA no no no no no no Proteoglycans in cancer cGMP-PKG signaling pathway 0 -0.559288538 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Chagas disease 0 -0.604743083 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Citrate cycle (TCA cycle) 0 0.57312253 0.521492921 kegg kegg NA NA no no no no no no Proteoglycans in cancer Collecting duct acid secretion -0.474782609 0 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Complement and coagulation cascades 0 -0.527667984 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Coronavirus disease - COVID-19 0.422608696 0.861660079 0.601029601 kegg kegg NA NA no no no no no no Proteoglycans in cancer Cysteine and methionine metabolism 0.42 0.687747036 0.653024453 kegg kegg NA NA no no no no no no Proteoglycans in cancer DNA replication 0 0.551383399 0.501415701 kegg kegg NA NA no no no no no no Proteoglycans in cancer Dopaminergic synapse 0 0.438735178 0 kegg kegg NA NA no no no no up no Proteoglycans in cancer Drug metabolism - cytochrome P450 0 0.645256917 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Drug metabolism - other enzymes 0 0.683794466 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer ECM-receptor interaction 0 0.419960474 0 kegg kegg NA NA no no no no up up Proteoglycans in cancer EGFR tyrosine kinase inhibitor resistance 0.810434783 0.906126482 0.794594595 kegg kegg NA NA no no no no no no Proteoglycans in cancer Endocrine and other factor-regulated calcium reabsorption 0 0.538537549 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Endocrine resistance 0 0 -0.443243243 kegg kegg NA NA no no no no no no Proteoglycans in cancer Epithelial cell signaling in Helicobacter pylori infection 0 -0.508893281 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Fat digestion and absorption 0 -0.614624506 0 yes kegg kegg NA NA no no no no up up Proteoglycans in cancer Fatty acid biosynthesis 0 -0.72826087 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Fatty acid degradation 0 -0.608695652 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Fatty acid elongation 0 0 0.493951094 kegg kegg NA NA no no no no no no Proteoglycans in cancer Fatty acid metabolism 0 -0.611660079 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Fc epsilon RI signaling pathway 0 -0.671936759 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Fc gamma R-mediated phagocytosis 0 -0.510869565 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Focal adhesion 0 0.538537549 0 kegg kegg NA NA no no no no up up Proteoglycans in cancer Folate biosynthesis 0 0.568181818 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer FoxO signaling pathway 0 -0.671936759 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Fructose and mannose metabolism 0 -0.588932806 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer GABAergic synapse -0.44 -0.570158103 -0.473873874 kegg kegg NA NA no no no no up up Proteoglycans in cancer Galactose metabolism 0 -0.64229249 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Gastric acid secretion 0 0.537549407 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Glucagon signaling pathway 0 0.543478261 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Glutamatergic synapse -0.460869565 -0.508893281 -0.488545689 kegg kegg NA NA no no no no up up Proteoglycans in cancer Glutathione metabolism 0 0.609683794 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Glycerolipid metabolism 0 -0.599802372 0 kegg kegg NA NA no no no no no up Proteoglycans in cancer Glycerophospholipid metabolism 0 -0.575098814 0 kegg kegg NA NA no no no no no up Proteoglycans in cancer "Glycine, serine and threonine metabolism" 0 0 -0.565765766 kegg kegg NA NA no no no no up no Proteoglycans in cancer Glycolysis / Gluconeogenesis 0 0.673913043 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.704545455 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Glycosaminoglycan degradation 0 -0.463438735 0 kegg kegg NA NA no no no no no up Proteoglycans in cancer Glycosphingolipid biosynthesis - globo and isoglobo series 0 0 -0.419305019 kegg kegg NA NA no no no no no no Proteoglycans in cancer Glyoxylate and dicarboxylate metabolism 0 -0.64229249 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer "Growth hormone synthesis, secretion and action" 0 -0.463438735 -0.521492921 kegg kegg NA NA no no no no no no Proteoglycans in cancer Hepatitis B 0 -0.719367589 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer HIF-1 signaling pathway 0.733043478 0.907114625 0.795881596 kegg kegg NA NA no no no no no no Proteoglycans in cancer Hippo signaling pathway 0 0.645256917 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Hippo signaling pathway - multiple species 0 -0.792490119 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Huntington disease 0 0.712450593 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer IL-17 signaling pathway 0 -0.509881423 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Inflammatory mediator regulation of TRP channels 0 0.559288538 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Inositol phosphate metabolism 0 -0.425889328 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Insulin resistance 0 -0.540513834 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Insulin signaling pathway 0.713043478 0.899209486 0.831660232 kegg kegg NA NA no no no no no no Proteoglycans in cancer Intestinal immune network for IgA production 0 0.464426877 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer JAK-STAT signaling pathway 0 -0.738142292 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Legionellosis 0.489565217 0.712450593 0.447104247 kegg kegg NA NA no no no no no no Proteoglycans in cancer Leishmaniasis 0 0.690711462 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Long-term potentiation 0 0.529644269 0.482625483 kegg kegg NA NA no no no no no up Proteoglycans in cancer Lysine degradation 0.629565217 0 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Lysosome -0.447826087 0 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Measles 0.465217391 0 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Melanogenesis 0 0.581027668 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Metabolism of xenobiotics by cytochrome P450 0 0.589920949 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Mismatch repair 0 0 0.448391248 kegg kegg NA NA no no no no no no Proteoglycans in cancer Mitophagy - animal 0 0.501976285 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer mRNA surveillance pathway 0 0.627470356 0.446846847 kegg kegg NA NA no no no no no no Proteoglycans in cancer mTOR signaling pathway 0.806956522 0.882411067 0.734620335 kegg kegg NA NA no no no no no no Proteoglycans in cancer N-Glycan biosynthesis 0 0.695652174 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Neuroactive ligand-receptor interaction 0 -0.416996047 0 kegg kegg NA NA no no no up up up Proteoglycans in cancer Neutrophil extracellular trap formation 0 -0.513833992 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer NF-kappa B signaling pathway 0 -0.699604743 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Nicotinate and nicotinamide metabolism 0 -0.757905138 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Nitrogen metabolism 0 -0.62055336 -0.563963964 kegg kegg NA NA no no no no no no Proteoglycans in cancer NOD-like receptor signaling pathway 0 -0.635375494 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Non-alcoholic fatty liver disease 0 0.626482213 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Nucleotide excision repair 0 0 0.444015444 kegg kegg NA NA no no no no no no Proteoglycans in cancer Olfactory transduction -0.423478261 -0.538537549 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Oocyte meiosis 0 0.631422925 0.543371943 kegg kegg NA NA no no no no no no Proteoglycans in cancer Osteoclast differentiation 0 -0.648221344 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Other glycan degradation 0 -0.458498024 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Ovarian steroidogenesis 0 0 -0.416731017 kegg kegg NA NA no no no no up up Proteoglycans in cancer Oxidative phosphorylation 0 0.718379447 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Pancreatic secretion 0 0.494071146 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Pantothenate and CoA biosynthesis -0.428695652 -0.820158103 0 kegg kegg NA NA no no no no no dn Proteoglycans in cancer Parabacteroides 0 0 -0.472488578 kegg Genus NA 4.19E-05 no no no no up up Proteoglycans in cancer "Parathyroid hormone synthesis, secretion and action" 0 0.530632411 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Parkinson disease 0 0.658102767 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Pathways in cancer 0 -0.488142292 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Pathways of neurodegeneration - multiple diseases 0 0.658102767 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Pentose and glucuronate interconversions 0 0.602766798 0.584813385 kegg kegg NA NA no no no no no no Proteoglycans in cancer Pentose phosphate pathway 0 -0.450592885 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Peroxisome 0 -0.678853755 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Pertussis -0.413043478 -0.554347826 0 kegg kegg NA NA no no no no no dn Proteoglycans in cancer Phenylalanine metabolism 0 0.421936759 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Phospholipase D signaling pathway -0.412173913 -0.738142292 -0.485714286 kegg kegg NA NA no no no no up up Proteoglycans in cancer Phototransduction 0 0.508893281 0.432175032 kegg kegg NA NA no no no no no no Proteoglycans in cancer PI3K-Akt signaling pathway 0.673043478 0.530632411 0.800514801 yes kegg kegg NA NA no no no no up up Proteoglycans in cancer Porphyrin and chlorophyll metabolism 0 0 -0.537451737 kegg kegg NA NA no no no no no no Proteoglycans in cancer PPAR signaling pathway 0 -0.43083004 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Prion disease 0 0.799407115 0.462290862 kegg kegg NA NA no no no no no no Proteoglycans in cancer Prolactin signaling pathway 0 -0.650197628 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Propanoate metabolism 0 0.677865613 0.661003861 kegg kegg NA NA no no no no no no Proteoglycans in cancer Proteasome 0 0.598814229 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Protein digestion and absorption 0 -0.602766798 0 yes kegg kegg NA NA no no no no up up Proteoglycans in cancer Protein export 0 0.804347826 0.661003861 kegg kegg NA NA no no no no no no Proteoglycans in cancer Protein processing in endoplasmic reticulum 0 0.666996047 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Proximal tubule bicarbonate reclamation 0 0.62055336 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Pyruvate metabolism 0 0.717391304 0.407722008 kegg kegg NA NA no no no no no no Proteoglycans in cancer Ras signaling pathway 0 0.62944664 0 yes kegg kegg NA NA no no no no up up Proteoglycans in cancer Renin secretion 0 0.529644269 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Renin-angiotensin system -0.439130435 -0.443675889 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Retrograde endocannabinoid signaling 0 0.738142292 0.481595882 kegg kegg NA NA no no no no no up Proteoglycans in cancer Ribosome 0.417391304 0.863636364 0.603088803 kegg kegg NA NA no no no no no no Proteoglycans in cancer Ribosome biogenesis in eukaryotes 0.439130435 0 0.49034749 kegg kegg NA NA no no no no no no Proteoglycans in cancer RIG-I-like receptor signaling pathway 0 -0.623517787 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer RNA degradation 0 0.75 0.593564994 kegg kegg NA NA no no no no no no Proteoglycans in cancer RNA polymerase 0 0.514822134 0.501930502 kegg kegg NA NA no no no no no no Proteoglycans in cancer RNA transport 0.64 0.878458498 0.700643501 kegg kegg NA NA no no no no no no Proteoglycans in cancer Roseburia -0.449565217 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no Proteoglycans in cancer Salivary secretion -0.448695652 0 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Serotonergic synapse 0 0 -0.525096525 kegg kegg NA NA no no no no no no Proteoglycans in cancer Shigellosis 0 0.56027668 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer SNARE interactions in vesicular transport 0 -0.60770751 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Spinocerebellar ataxia 0 0.509881423 0.593307593 kegg kegg NA NA no no no no no no Proteoglycans in cancer Spliceosome 0.494782609 0 0.503217503 kegg kegg NA NA no no no no no no Proteoglycans in cancer Starch and sucrose metabolism 0 -0.808300395 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Sulfur metabolism 0 0 -0.45971686 kegg kegg NA NA no no no no no no Proteoglycans in cancer Synaptic vesicle cycle 0 -0.500988142 0 kegg kegg NA NA no no no no up up Proteoglycans in cancer T cell receptor signaling pathway 0.534782609 0 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Taurine and hypotaurine metabolism 0 -0.490118577 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer TGF-beta signaling pathway 0 0.726284585 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Th17 cell differentiation 0 0 0.404118404 kegg kegg NA NA no no no no no no Proteoglycans in cancer Thermogenesis 0 0.785573123 0.522522523 kegg kegg NA NA no no no no no no Proteoglycans in cancer Thiamine metabolism 0.611304348 0.574110672 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Thyroid hormone signaling pathway 0 0.551383399 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Thyroid hormone synthesis 0 0 -0.418532819 kegg kegg NA NA no no no no no no Proteoglycans in cancer Tight junction 0 0.471343874 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer TNF signaling pathway 0 -0.496047431 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Toll-like receptor signaling pathway 0 -0.591897233 0 yes kegg kegg NA NA no no no no no no Proteoglycans in cancer Transcriptional misregulation in cancer 0 -0.754940711 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Tryptophan metabolism 0 0 0.49009009 kegg kegg NA NA no no no no up no Proteoglycans in cancer Tuberculosis -0.487826087 0 0 kegg kegg NA NA no no no no no dn Proteoglycans in cancer Type II diabetes mellitus 0 -0.518774704 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Ubiquitin mediated proteolysis 0 0.529644269 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer "Valine, leucine and isoleucine degradation" 0 0 0.548005148 kegg kegg NA NA no no no no no no Proteoglycans in cancer Various types of N-glycan biosynthesis 0 0.600790514 0.438610039 kegg kegg NA NA no no no no no no Proteoglycans in cancer Vascular smooth muscle contraction 0 0.524703557 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Vasopressin-regulated water reabsorption 0 0.494071146 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Vitamin digestion and absorption 0 -0.449604743 0 kegg kegg NA NA no no no no no no Proteoglycans in cancer Wnt signaling pathway 0 0.708498024 0.44015444 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation 2-Oxocarboxylic acid metabolism 0 0.683794466 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Adherens junction 0 0.463438735 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Adipocytokine signaling pathway -0.50173913 -0.673913043 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Adrenergic signaling in cardiomyocytes 0 0.479249012 0 kegg kegg NA NA no no no no no up Proximal tubule bicarbonate reclamation AGE-RAGE signaling pathway in diabetic complications 0 -0.694664032 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation "Alanine, aspartate and glutamate metabolism" 0 -0.734189723 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Aldosterone synthesis and secretion 0 0.515810277 0 kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation alpha-Linolenic acid metabolism 0 -0.434782609 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Aminoacyl-tRNA biosynthesis 0 0.566205534 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Antifolate resistance 0 0.489130435 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Apelin signaling pathway 0 0.64229249 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Apoptosis -0.515652174 -0.766798419 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Arginine and proline metabolism 0 -0.644268775 0 kegg kegg NA NA no no no no up no Proximal tubule bicarbonate reclamation Arginine biosynthesis -0.412173913 -0.756916996 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Ascorbate and aldarate metabolism 0 0.580039526 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Autophagy - animal 0 -0.708498024 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation B cell receptor signaling pathway -0.59826087 -0.744071146 -0.454568855 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Basal transcription factors 0.502608696 0.58201581 0.57039897 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Base excision repair 0.435652174 0.601778656 0.537966538 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation beta-Alanine metabolism 0 0.446640316 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Biosynthesis of amino acids 0 -0.64229249 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Biosynthesis of cofactors 0 0.561264822 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Biosynthesis of unsaturated fatty acids 0.547826087 0.420948617 0.513513514 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Butanoate metabolism 0 0.769762846 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation C-type lectin receptor signaling pathway -0.443478261 -0.820158103 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation cAMP signaling pathway 0 -0.651185771 0 yes kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation Cardiac muscle contraction 0 0.466403162 0 kegg kegg NA NA no no no no no up Proximal tubule bicarbonate reclamation Cell adhesion molecules 0 -0.436758893 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Cell cycle 0.605217391 0.751976285 0.581724582 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Cellular senescence 0 -0.603754941 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation cGMP-PKG signaling pathway 0 -0.66798419 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Chemokine signaling pathway 0 -0.579051383 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Circadian entrainment 0.450434783 0.476284585 0 kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation Circadian rhythm 0 0.435770751 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Citrate cycle (TCA cycle) 0.517391304 0.806324111 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Complement and coagulation cascades 0 -0.570158103 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Cysteine and methionine metabolism 0.742608696 0.757905138 0.463320463 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Cytosolic DNA-sensing pathway 0 -0.508893281 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation DNA replication 0.648695652 0.850790514 0.449420849 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Dopaminergic synapse 0 0.513833992 0 kegg kegg NA NA no no no no up no Proximal tubule bicarbonate reclamation Drug metabolism - cytochrome P450 0.515652174 0.865612648 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Drug metabolism - other enzymes 0 0.779644269 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation ECM-receptor interaction 0.593043478 0.619565217 0 kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation EGFR tyrosine kinase inhibitor resistance 0 0.515810277 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Endocrine and other factor-regulated calcium reabsorption 0 0.489130435 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Endocytosis 0 -0.471343874 -0.464864865 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Estrogen signaling pathway 0.74 0.711462451 0.422136422 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Ether lipid metabolism 0 0.496047431 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Fanconi anemia pathway 0.567826087 0.471343874 0.59021879 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Fatty acid biosynthesis 0 -0.750988142 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Fatty acid degradation 0 -0.483201581 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Fatty acid elongation 0 0.433794466 0.401801802 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Fatty acid metabolism 0 -0.423913043 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Fc epsilon RI signaling pathway -0.56173913 -0.816205534 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Fc gamma R-mediated phagocytosis 0 -0.578063241 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Focal adhesion 0 0.517786561 0 kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation Folate biosynthesis 0 0.571146245 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation FoxO signaling pathway 0 -0.415019763 0.483655084 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Fructose and mannose metabolism 0 -0.431818182 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation GABAergic synapse 0 -0.483201581 0 kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation Galactose metabolism 0 -0.414031621 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Glucagon signaling pathway 0.517391304 0.652173913 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Glutathione metabolism 0 0.576086957 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Glycerolipid metabolism -0.537391304 0 0 kegg kegg NA NA no no no no no up Proximal tubule bicarbonate reclamation Glycolysis / Gluconeogenesis 0 0.523715415 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.685217391 -0.732213439 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.613636364 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Glycosaminoglycan degradation -0.552173913 0 0 kegg kegg NA NA no no no no no up Proximal tubule bicarbonate reclamation Glycosphingolipid biosynthesis - ganglio series 0 0.535573123 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Glycosphingolipid biosynthesis - lacto and neolacto series -0.559130435 0 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Glyoxylate and dicarboxylate metabolism 0 -0.754940711 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation GnRH secretion 0 -0.433794466 0 kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation Hedgehog signaling pathway 0 0.502964427 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Hematopoietic cell lineage 0 0.477272727 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation HIF-1 signaling pathway 0 0.482213439 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Hippo signaling pathway 0 0.585968379 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Homologous recombination 0.486086957 0 0.671814672 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation IL-17 signaling pathway -0.509565217 -0.742094862 -0.42985843 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Inflammatory mediator regulation of TRP channels 0 0.557312253 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Insulin resistance 0 -0.65513834 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Insulin signaling pathway 0 0.62055336 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation JAK-STAT signaling pathway 0 -0.557312253 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Linoleic acid metabolism 0 0.441699605 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Long-term potentiation 0 0.659090909 0.470785071 kegg kegg NA NA no no no no no up Proximal tubule bicarbonate reclamation Longevity regulating pathway - multiple species 0.507826087 0 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Lysosome -0.668695652 -0.502964427 -0.444530245 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Mannose type O-glycan biosynthesis -0.408695652 0 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Melanogenesis 0 0.556324111 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Metabolism of xenobiotics by cytochrome P450 0.472173913 0.83201581 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Mismatch repair 0.674782609 0.812252964 0.592792793 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation mRNA surveillance pathway 0 0.590909091 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation mTOR signaling pathway 0 0.490118577 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Mucin type O-glycan biosynthesis 0.485217391 0 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation N-Glycan biosynthesis 0.444347826 0.843873518 0.422651223 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Natural killer cell mediated cytotoxicity 0 -0.559288538 -0.425225225 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Neuroactive ligand-receptor interaction 0 -0.429841897 0 kegg kegg NA NA no no no up up up Proximal tubule bicarbonate reclamation Neurotrophin signaling pathway 0 -0.636363636 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Neutrophil extracellular trap formation -0.493913043 -0.588932806 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation NF-kappa B signaling pathway -0.406086957 -0.731225296 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Nicotinate and nicotinamide metabolism 0 -0.777667984 -0.41003861 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Nitrogen metabolism -0.442608696 -0.701581028 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation NOD-like receptor signaling pathway 0 -0.773715415 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Non-homologous end-joining 0.424347826 0.57312253 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Notch signaling pathway -0.428695652 0 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Nucleotide excision repair 0.702608696 0.82312253 0.613642214 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Olfactory transduction 0 -0.492094862 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation One carbon pool by folate 0.604347826 0.793478261 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Oocyte meiosis 0.63826087 0.73715415 0.693178893 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Osteoclast differentiation -0.584347826 -0.803359684 -0.424710425 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Oxidative phosphorylation 0 0.4743083 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Pantothenate and CoA biosynthesis 0 -0.603754941 0 kegg kegg NA NA no no no no no dn Proximal tubule bicarbonate reclamation Pentose and glucuronate interconversions 0.626086957 0.837944664 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Pentose phosphate pathway -0.626956522 -0.616600791 -0.440669241 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Peroxisome 0 -0.601778656 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Phagosome -0.409565217 -0.499011858 -0.475675676 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Phenylalanine metabolism 0 0.730237154 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Phosphatidylinositol signaling system 0 0 0.405662806 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Phospholipase D signaling pathway -0.50173913 -0.704545455 -0.423423423 kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation Phototransduction 0.451304348 0.53458498 0.587644788 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Platinum drug resistance 0 0 0.584813385 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation PPAR signaling pathway 0 -0.78458498 -0.407207207 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Primary bile acid biosynthesis 0.564347826 0.500988142 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Progesterone-mediated oocyte maturation 0 0 0.403346203 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Prolactin signaling pathway 0 -0.820158103 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Propanoate metabolism 0.585217391 0.690711462 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Proteasome 0 0.585968379 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Protein export 0.536521739 0.723320158 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Protein processing in endoplasmic reticulum 0.530434783 0.765810277 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Pyrimidine metabolism 0 0.773715415 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Pyruvate metabolism 0.640869565 0.750988142 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Ras signaling pathway 0 0.802371542 0.438095238 yes kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation Regulation of actin cytoskeleton 0 0.488142292 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Relaxin signaling pathway 0 -0.649209486 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Renin secretion 0.48 0.597826087 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Renin-angiotensin system 0 -0.546442688 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Retinol metabolism 0.487826087 0.66798419 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Retrograde endocannabinoid signaling 0 0.580039526 0 kegg kegg NA NA no no no no no up Proximal tubule bicarbonate reclamation Ribosome 0 0.499011858 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Ribosome biogenesis in eukaryotes 0.454782609 0.657114625 0.523809524 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation RIG-I-like receptor signaling pathway 0 -0.731225296 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation RNA degradation 0 0.76284585 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation RNA polymerase 0.468695652 0.719367589 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation RNA transport 0.414782609 0.467391304 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Sphingolipid metabolism -0.646956522 0 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Sphingolipid signaling pathway 0 -0.477272727 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Spliceosome 0 0 0.518146718 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Starch and sucrose metabolism 0 -0.623517787 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Steroid biosynthesis 0.593043478 0.67687747 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Steroid hormone biosynthesis 0 0.644268775 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Synaptic vesicle cycle -0.415652174 -0.548418972 -0.458944659 kegg kegg NA NA no no no no up up Proximal tubule bicarbonate reclamation Synthesis and degradation of ketone bodies 0.594782609 0.694664032 0.529472329 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Taste transduction 0.543478261 0.656126482 0 kegg kegg NA NA no no no no no up Proximal tubule bicarbonate reclamation Terpenoid backbone biosynthesis 0.660869565 0.484189723 0.424453024 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation TGF-beta signaling pathway 0 0.709486166 0.526640927 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Thermogenesis 0 0.545454545 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Thiamine metabolism 0 0.575098814 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Thyroid hormone signaling pathway 0 0.42687747 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation TNF signaling pathway 0 -0.744071146 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Toll-like receptor signaling pathway 0 -0.866600791 -0.495238095 yes kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Tryptophan metabolism 0 0.613636364 0 kegg kegg NA NA no no no no up no Proximal tubule bicarbonate reclamation Type II diabetes mellitus 0 -0.498023715 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Tyrosine metabolism 0.576521739 0.750988142 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Ubiquinone and other terpenoid-quinone biosynthesis 0 0.750988142 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation "Valine, leucine and isoleucine degradation" 0.44 0.769762846 0.463577864 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Various types of N-glycan biosynthesis 0 0.748023715 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Vascular smooth muscle contraction 0 0.481225296 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Vasopressin-regulated water reabsorption 0 0.519762846 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation VEGF signaling pathway 0 -0.4743083 0 kegg kegg NA NA no no no no no no Proximal tubule bicarbonate reclamation Wnt signaling pathway 0 0.767786561 0 kegg kegg NA NA no no no no no no PUFA/MUFA+blood "12,13-EPOME+blood" 0 0 -0.40857856 serum_fattyacid serum_ARA 0.00108 0.901 dn no up no no no PUFA/MUFA+blood 16:0/14:0-PC+blood 0 0 0.414017094 serum_fattyacid serum_phospholipids 0.00108 0.0206 dn no up no up up PUFA/MUFA+blood 16:0/16:1-PI+blood 0 -0.507352941 0 serum_fattyacid serum_phospholipids 0.00108 0.262 dn no up no no no PUFA/MUFA+blood 16:0/18:0-PC+blood 0 0 0.51042735 serum_fattyacid serum_phospholipids 0.00108 0.521 dn no up no no no PUFA/MUFA+blood 16:0/18:0-PS+blood 0 -0.492647059 0 serum_fattyacid serum_phospholipids 0.00108 0.377 dn no up no no no PUFA/MUFA+blood 16:0/18:1-PE+blood 0 0 -0.60957265 serum_fattyacid serum_phospholipids 0.00108 0.000107 dn no up up up no PUFA/MUFA+blood 16:0/18:2-PC+blood 0 0.485294118 0 serum_fattyacid serum_phospholipids 0.00108 3.24E-06 dn no up no up up PUFA/MUFA+blood 16:0/20:4-PE+blood 0 0 -0.72034188 serum_fattyacid serum_phospholipids 0.00108 0.00139 dn no up up up no PUFA/MUFA+blood 16:0/20:4-PI+blood 0 -0.553921569 0 serum_fattyacid serum_phospholipids 0.00108 0.558 dn no up no no no PUFA/MUFA+blood 16:0/22:0-PE+blood 0 0 0.496068376 serum_fattyacid serum_phospholipids 0.00108 0.00839 dn no up dn no up PUFA/MUFA+blood 16:0/22:6-PE+blood 0 0 -0.598632479 serum_fattyacid serum_phospholipids 0.00108 0.000934 dn no up up up no PUFA/MUFA+blood 16:0+blood -0.535338346 0 0 yes serum_fattyacid serum_fattyacid 0.00108 0.00876 dn no up up no no PUFA/MUFA+blood 16:1+blood -0.49924812 -0.50245098 -0.532991453 yes serum_fattyacid serum_fattyacid 0.00108 0.0186 dn no up no no dn PUFA/MUFA+blood 18:0-LPE+blood -0.50075188 0 0 serum_fattyacid serum_phospholipids 0.00108 0.491 dn no up no no no PUFA/MUFA+blood 18:0/18:0-PS+blood 0 -0.524509804 0 serum_fattyacid serum_phospholipids 0.00108 0.00617 dn no up no up no PUFA/MUFA+blood 18:0/18:1-PE+blood 0 0 -0.446837607 serum_fattyacid serum_phospholipids 0.00108 0.00716 dn no up up up no PUFA/MUFA+blood 18:0/18:1-PG+blood 0 -0.487745098 -0.441367521 serum_fattyacid serum_phospholipids 0.00108 0.000842 dn no up no up no PUFA/MUFA+blood 18:0/18:1-PI+blood 0 -0.534313725 0 serum_fattyacid serum_phospholipids 0.00108 0.599 dn no up no no no PUFA/MUFA+blood 18:0/18:2-PC+blood 0 0 0.433162393 serum_fattyacid serum_phospholipids 0.00108 1.74E-06 dn no up no up up PUFA/MUFA+blood 18:0/20:3-PI+blood -0.527819549 0 0 serum_fattyacid serum_phospholipids 0.00108 0.377 dn no up no no no PUFA/MUFA+blood 18:0/22:6-PA+blood 0 0 0.45982906 serum_fattyacid serum_phospholipids 0.00108 0.22 dn no up no no no PUFA/MUFA+blood 18:0+blood -0.469172932 0 0 serum_fattyacid serum_fattyacid 0.00108 0.344 dn no up no no no PUFA/MUFA+blood 18:1-LPE+blood -0.494736842 0 0 serum_fattyacid serum_phospholipids 0.00108 0.117 dn no up no no no PUFA/MUFA+blood 18:1/16:0-PC+blood 0.445112782 0.485294118 0 serum_fattyacid serum_phospholipids 0.00108 2.43E-05 dn no up no up up PUFA/MUFA+blood 18:1/16:0-PE+blood 0 0 -0.601367521 serum_fattyacid serum_phospholipids 0.00108 0.000182 dn no up up up no PUFA/MUFA+blood 18:1/16:1-PE+blood 0 0 -0.684786325 serum_fattyacid serum_phospholipids 0.00108 0.000184 dn no up up up no PUFA/MUFA+blood 18:1/18:0-PC+blood 0 0 0.446837607 serum_fattyacid serum_phospholipids 0.00108 1.83E-06 dn no up no up up PUFA/MUFA+blood 18:1/18:0-PE+blood 0 0 -0.712820513 serum_fattyacid serum_phospholipids 0.00108 1.39E-06 dn no up up up no PUFA/MUFA+blood 18:1/18:0-PI+blood -0.514285714 0 0 serum_fattyacid serum_phospholipids 0.00108 0.0931 dn no up no no up PUFA/MUFA+blood 18:1/18:1-PE+blood 0 0 -0.723760684 serum_fattyacid serum_phospholipids 0.00108 1.03E-05 dn no up up up no PUFA/MUFA+blood 18:1/18:1-PI+blood 0 -0.632352941 0 serum_fattyacid serum_phospholipids 0.00108 0.111 dn no up dn no no PUFA/MUFA+blood 18:1/18:2-PE+blood 0 0 -0.630769231 serum_fattyacid serum_phospholipids 0.00108 0.000293 dn no up up up no PUFA/MUFA+blood 18:1/18:2-PG+blood 0 0 0.417435897 serum_fattyacid serum_phospholipids 0.00108 5.58E-07 dn no up no up up PUFA/MUFA+blood 18:1/20:4-PE+blood 0 -0.492647059 -0.60957265 serum_fattyacid serum_phospholipids 0.00108 0.0578 dn no up up no no PUFA/MUFA+blood 18:1+blood -0.742857143 0 -0.586324786 yes serum_fattyacid serum_fattyacid 0.00108 0.00202 dn no up up no dn PUFA/MUFA+blood 18:2-LPA+blood 0 0.490196078 0 serum_fattyacid serum_phospholipids 0.00108 0.00684 dn no up dn no up PUFA/MUFA+blood 18:2-LPE+blood 0 0.509803922 0 serum_fattyacid serum_phospholipids 0.00108 0.112 dn no up no no no PUFA/MUFA+blood 18:2/16:0-PC+blood 0 0.620098039 0.458461538 serum_fattyacid serum_phospholipids 0.00108 8.67E-05 dn no up no up up PUFA/MUFA+blood 20:0-LPC+blood -0.556390977 0 0 serum_fattyacid serum_phospholipids 0.00108 0.199 dn no up no no no PUFA/MUFA+blood 20:1-LPA+blood 0.503759398 0 0 serum_fattyacid serum_phospholipids 0.00108 0.0187 dn no up dn dn no PUFA/MUFA+blood 20:1-LPC+blood 0 0 0.468034188 serum_fattyacid serum_phospholipids 0.00108 0.217 dn no up no no no PUFA/MUFA+blood 20:1/20:4-PE+blood 0 -0.541666667 -0.434529915 serum_fattyacid serum_phospholipids 0.00108 0.0042 dn no up up up no PUFA/MUFA+blood 20:2-LPC+blood 0 0 0.571965812 serum_fattyacid serum_phospholipids 0.00108 0.119 dn no up no no up PUFA/MUFA+blood 20:2/18:1-PE+blood 0 0 -0.437264957 serum_fattyacid serum_phospholipids 0.00108 0.00208 dn no up up up no PUFA/MUFA+blood 20:2/18:3-PE+blood 0 0 -0.426324786 serum_fattyacid serum_phospholipids 0.00108 0.0391 dn no up up up no PUFA/MUFA+blood 20:2+blood 0 0.519607843 0 serum_fattyacid serum_fattyacid 0.00108 0.478 dn no up no no no PUFA/MUFA+blood 20:3-LPE+blood -0.572932331 0 0 serum_fattyacid serum_phospholipids 0.00108 0.084 dn no up no up no PUFA/MUFA+blood 20:3/18:0-PC+blood 0 0 0.442735043 serum_fattyacid serum_phospholipids 0.00108 0.296 dn no up no no no PUFA/MUFA+blood 20:4-LPA+blood 0 0.492647059 0 serum_fattyacid serum_phospholipids 0.00108 0.398 dn no up no no no PUFA/MUFA+blood 20:4/18:0-PE+blood 0 0 -0.647179487 serum_fattyacid serum_phospholipids 0.00108 0.000755 dn no up up up no PUFA/MUFA+blood 22:2-LPA+blood 0.520300752 0 0 serum_fattyacid serum_phospholipids 0.00108 0.0443 dn no up dn no no PUFA/MUFA+blood AGE-RAGE signaling pathway in diabetic complications 0 0 -0.403076923 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood B cell receptor signaling pathway 0 0.526470588 0 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood C-type lectin receptor signaling pathway 0 0.532352941 -0.414615385 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Cell adhesion molecules 0 0 -0.438461538 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Cell cycle 0 -0.623529412 0 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood cGMP-PKG signaling pathway 0 0 -0.44 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Chagas disease 0 0.585294118 0 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Choline+blood 0 0.637254902 0 serum_fattyacid serum_choline 0.00108 0.0395 dn no up no up no PUFA/MUFA+blood Clostridium 0 -0.513014322 0.446314805 serum_fattyacid Genus 0.00108 0.925 dn no up no no no PUFA/MUFA+blood Cytosolic DNA-sensing pathway 0.570175439 0 0 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood d18:0-24:1-SM+blood -0.484210526 0 0 serum_fattyacid serum_phospholipids 0.00108 0.0609 dn no up no dn dn PUFA/MUFA+blood d18:1-14:1-SM+blood 0 -0.526960784 0 serum_fattyacid serum_phospholipids 0.00108 0.0952 dn no up no dn no PUFA/MUFA+blood DHA+blood 0 0.539215686 0 serum_fattyacid serum_ARA 0.00108 0.872 dn no up no no no PUFA/MUFA+blood DPA+blood 0 0.485294118 0 serum_fattyacid serum_ARA 0.00108 0.519 dn no up no no no PUFA/MUFA+blood Epithelial cell signaling in Helicobacter pylori infection 0 0.605882353 -0.499230769 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Estrogen signaling pathway 0 -0.614705882 0 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Ethanolamine+blood 0 0.799019608 0 serum_fattyacid serum_aminoacids 0.00108 0.122 dn no up up no no PUFA/MUFA+blood GDCA+blood 0 0.531862745 0 serum_fattyacid serum_bileacids 0.00108 0.632 dn no up no no no PUFA/MUFA+blood GLCA+blood 0 0 -0.41825818 serum_fattyacid serum_bileacids 0.00108 0.319 dn no up no no no PUFA/MUFA+blood Glycine+blood 0 0.522058824 0.417435897 serum_fattyacid serum_aminoacids 0.00108 0.00408 dn no up dn no up PUFA/MUFA+blood HDCA+blood 0.457488141 0 0 serum_fattyacid serum_bileacids 0.00108 0.483 dn no up no no no PUFA/MUFA+blood Hypotaurine+blood 0 0.5 0 serum_fattyacid serum_aminoacids 0.00108 0.933 dn no up no no no PUFA/MUFA+blood L-Arginine+blood 0 0 0.402393162 serum_fattyacid serum_aminoacids 0.00108 0.316 dn no up no no no PUFA/MUFA+blood L-Asparagine+blood 0 0 0.466666667 serum_fattyacid serum_aminoacids 0.00108 0.784 dn no up no no no PUFA/MUFA+blood L-Aspartic acid+blood 0.496240602 0 0 yes serum_fattyacid serum_aminoacids 0.00108 0.0226 dn no up up up no PUFA/MUFA+blood L-Glutamic acid+blood 0 0.504901961 0 yes serum_fattyacid serum_aminoacids 0.00108 6.20E-05 dn no up up up no PUFA/MUFA+blood L-Phenylalanine+stool 0 0 0.458646617 serum_fattyacid stool_cometabolism 0.00108 0.398 dn no up no no no PUFA/MUFA+blood L-Tyrosine+stool 0 0 0.566917293 serum_fattyacid stool_cometabolism 0.00108 0.44 dn no up no no no PUFA/MUFA+blood Lipid and atherosclerosis 0 0 -0.481538462 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Long-term potentiation 0 -0.55 0 serum_fattyacid kegg 0.00108 NA dn no up no no up PUFA/MUFA+blood mRNA surveillance pathway 0 -0.576470588 0 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood MUFA+blood -0.706766917 0 -0.599316239 serum_fattyacid serum_fattyacid 0.00108 0.00175 dn no up up no dn PUFA/MUFA+blood n6/n3+blood 0 0.492647059 0 serum_fattyacid serum_fattyacid 0.00108 0.226 dn no up no no no PUFA/MUFA+blood NOD-like receptor signaling pathway 0 0.505882353 -0.473076923 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Odoribacter -0.454434217 0 0 butyrate-producing serum_fattyacid Genus 0.00108 0.798 dn no up no no no PUFA/MUFA+blood Oocyte meiosis 0 -0.635294118 0 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Osteoclast differentiation 0 0 -0.519230769 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood PD-L1 expression and PD-1 checkpoint pathway in cancer 0 0.585294118 0 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Pertussis 0 0 -0.438461538 serum_fattyacid kegg 0.00108 NA dn no up no no dn PUFA/MUFA+blood PPAR signaling pathway 0 0.544117647 -0.581538462 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Protein processing in endoplasmic reticulum 0 -0.579411765 0 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Proteoglycans in cancer 0.484210526 0 0 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Ras signaling pathway 0 -0.717647059 0 yes serum_fattyacid kegg 0.00108 NA dn no up no up up PUFA/MUFA+blood Regulation of actin cytoskeleton 0 -0.517647059 0 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood TNF signaling pathway 0 0.538235294 0 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Toll-like receptor signaling pathway 0 0.579411765 -0.5 yes serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Transcriptional misregulation in cancer 0 0 -0.420769231 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/MUFA+blood Wnt signaling pathway 0 -0.608823529 0 serum_fattyacid kegg 0.00108 NA dn no up no no no PUFA/UFA+blood 13-HODE+blood 0 0.531862745 0 serum_fattyacid serum_ARA 0.000732 0.32 dn no up no no no PUFA/UFA+blood 16:0/14:0-PC+blood 0.533834586 0 0.45025641 serum_fattyacid serum_phospholipids 0.000732 0.0206 dn no up no up up PUFA/UFA+blood 16:0/16:0-PC+blood 0.505263158 0 0 serum_fattyacid serum_phospholipids 0.000732 0.00079 dn no up no up up PUFA/UFA+blood 16:0/16:0-PI+blood -0.535338346 0 0 serum_fattyacid serum_phospholipids 0.000732 0.358 dn no up no no no PUFA/UFA+blood 16:0/16:1-PI+blood -0.598496241 0 0 serum_fattyacid serum_phospholipids 0.000732 0.262 dn no up no no no PUFA/UFA+blood 16:0/18:1-PC+blood 0.673684211 0 0 serum_fattyacid serum_phospholipids 0.000732 6.15E-07 dn no up up up up PUFA/UFA+blood 16:0/18:1-PE+blood 0 0 -0.424273504 serum_fattyacid serum_phospholipids 0.000732 0.000107 dn no up up up no PUFA/UFA+blood 16:0/18:2-PC+blood 0.679699248 0.659313725 0.514529915 serum_fattyacid serum_phospholipids 0.000732 3.24E-06 dn no up no up up PUFA/UFA+blood 16:0/18:2-PI+blood -0.472180451 0 0 serum_fattyacid serum_phospholipids 0.000732 0.269 dn no up no no no PUFA/UFA+blood 16:0/20:3-PC+blood 0.542857143 0 0.411965812 serum_fattyacid serum_phospholipids 0.000732 5.43E-06 dn no up no up up PUFA/UFA+blood 16:0/20:4-PC+blood 0.57593985 0 0 serum_fattyacid serum_phospholipids 0.000732 0.0262 dn no up no up no PUFA/UFA+blood 16:0/20:4-PE+blood 0 0 -0.500854701 serum_fattyacid serum_phospholipids 0.000732 0.00139 dn no up up up no PUFA/UFA+blood 16:0/20:4-PI+blood -0.603007519 -0.556372549 0 serum_fattyacid serum_phospholipids 0.000732 0.558 dn no up no no no PUFA/UFA+blood 16:0/22:0-PE+blood 0 0 0.520683761 serum_fattyacid serum_phospholipids 0.000732 0.00839 dn no up dn no up PUFA/UFA+blood 16:0/22:6-PC+blood 0 0 0.597264957 serum_fattyacid serum_phospholipids 0.000732 4.53E-05 dn no up no up up PUFA/UFA+blood 16:1/16:0-PC+blood 0.578947368 0 0 serum_fattyacid serum_phospholipids 0.000732 0.0215 dn no up no up up PUFA/UFA+blood 18:0-LPA+blood 0 0.531862745 0 serum_fattyacid serum_phospholipids 0.000732 0.0725 dn no up no dn no PUFA/UFA+blood 18:0-LPE+blood -0.508270677 0 -0.461880342 serum_fattyacid serum_phospholipids 0.000732 0.491 dn no up no no no PUFA/UFA+blood 18:0/16:0-PC+blood 0.655639098 0 0 serum_fattyacid serum_phospholipids 0.000732 9.64E-07 dn no up up up up PUFA/UFA+blood 18:0/18:0-PE+blood -0.484210526 0 -0.460512821 serum_fattyacid serum_phospholipids 0.000732 0.00896 dn no up up up no PUFA/UFA+blood 18:0/18:0-PS+blood 0 -0.553921569 0 serum_fattyacid serum_phospholipids 0.000732 0.00617 dn no up no up no PUFA/UFA+blood 18:0/18:1-PE+blood -0.506766917 0 -0.526837607 serum_fattyacid serum_phospholipids 0.000732 0.00716 dn no up up up no PUFA/UFA+blood 18:0/18:1-PG+blood 0 0 -0.593162393 serum_fattyacid serum_phospholipids 0.000732 0.000842 dn no up no up no PUFA/UFA+blood 18:0/18:2-PC+blood 0.578947368 0 0.614358974 serum_fattyacid serum_phospholipids 0.000732 1.74E-06 dn no up no up up PUFA/UFA+blood 18:0/20:4-PC+blood 0.527819549 0 0 serum_fattyacid serum_phospholipids 0.000732 0.454 dn no up no no no PUFA/UFA+blood 18:0/20:5-PC+blood 0.47518797 0 0 serum_fattyacid serum_phospholipids 0.000732 0.17 dn no up no no no PUFA/UFA+blood 18:1/16:0-PC+blood 0.682706767 0.659313725 0.504273504 serum_fattyacid serum_phospholipids 0.000732 2.43E-05 dn no up no up up PUFA/UFA+blood 18:1/16:0-PE+blood 0 0 -0.598632479 serum_fattyacid serum_phospholipids 0.000732 0.000182 dn no up up up no PUFA/UFA+blood 18:1/16:0-PI+blood -0.485714286 0 0 serum_fattyacid serum_phospholipids 0.000732 0.793 dn no up no no no PUFA/UFA+blood 18:1/16:1-PE+blood 0 0 -0.511794872 serum_fattyacid serum_phospholipids 0.000732 0.000184 dn no up up up no PUFA/UFA+blood 18:1/18:0-PC+blood 0.618045113 0 0.625982906 serum_fattyacid serum_phospholipids 0.000732 1.83E-06 dn no up no up up PUFA/UFA+blood 18:1/18:0-PE+blood 0 0 -0.571965812 serum_fattyacid serum_phospholipids 0.000732 1.39E-06 dn no up up up no PUFA/UFA+blood 18:1/18:0-PI+blood -0.464661654 -0.5 0 serum_fattyacid serum_phospholipids 0.000732 0.0931 dn no up no no up PUFA/UFA+blood 18:1/18:1-PC+blood 0.503759398 0 0 serum_fattyacid serum_phospholipids 0.000732 1.34E-05 dn no up no up up PUFA/UFA+blood 18:1/18:1-PE+blood 0 0 -0.55965812 serum_fattyacid serum_phospholipids 0.000732 1.03E-05 dn no up up up no PUFA/UFA+blood 18:1/18:2-PE+blood 0 0 -0.632820513 serum_fattyacid serum_phospholipids 0.000732 0.000293 dn no up up up no PUFA/UFA+blood 18:1/20:4-PE+blood 0 0 -0.601367521 serum_fattyacid serum_phospholipids 0.000732 0.0578 dn no up up no no PUFA/UFA+blood 18:2-LPA+blood 0 0.517156863 0 serum_fattyacid serum_phospholipids 0.000732 0.00684 dn no up dn no up PUFA/UFA+blood 18:2/16:0-PC+blood 0.654135338 0.529411765 0.473504274 serum_fattyacid serum_phospholipids 0.000732 8.67E-05 dn no up no up up PUFA/UFA+blood 18:3/16:0-PE+blood 0 -0.49754902 -0.517264957 serum_fattyacid serum_phospholipids 0.000732 0.00149 dn no up up up no PUFA/UFA+blood 18:3n6+blood -0.508270677 0 0 serum_fattyacid serum_fattyacid 0.000732 0.0463 dn no up up no dn PUFA/UFA+blood 20:0-LPE+blood 0 -0.514705882 0 serum_fattyacid serum_phospholipids 0.000732 0.0615 dn no up no no up PUFA/UFA+blood 20:0/20:4-PE+blood 0 0 -0.515213675 serum_fattyacid serum_phospholipids 0.000732 0.00128 dn no up up up no PUFA/UFA+blood 20:1-LPC+blood 0 0 0.443418803 serum_fattyacid serum_phospholipids 0.000732 0.217 dn no up no no no PUFA/UFA+blood 20:1/20:4-PC+blood 0 0 0.432478632 serum_fattyacid serum_phospholipids 0.000732 0.0419 dn no up no no up PUFA/UFA+blood 20:1/20:4-PE+blood 0 0 -0.541880342 serum_fattyacid serum_phospholipids 0.000732 0.0042 dn no up up up no PUFA/UFA+blood 20:2-LPC+blood 0 0 0.511111111 serum_fattyacid serum_phospholipids 0.000732 0.119 dn no up no no up PUFA/UFA+blood 20:2/18:1-PE+blood -0.494736842 0 -0.40991453 serum_fattyacid serum_phospholipids 0.000732 0.00208 dn no up up up no PUFA/UFA+blood 20:2+blood 0 0.522058824 0 serum_fattyacid serum_fattyacid 0.000732 0.478 dn no up no no no PUFA/UFA+blood 20:3/16:0-PC+blood 0.587969925 0 0 serum_fattyacid serum_phospholipids 0.000732 0.00405 dn no up no up up PUFA/UFA+blood 20:3/18:0-PC+blood 0 0 0.48034188 serum_fattyacid serum_phospholipids 0.000732 0.296 dn no up no no no PUFA/UFA+blood 20:3n6+blood -0.464661654 0 0 serum_fattyacid serum_fattyacid 0.000732 0.0884 dn no up up no no PUFA/UFA+blood 20:4-LPA+blood 0 0.62254902 0 serum_fattyacid serum_phospholipids 0.000732 0.398 dn no up no no no PUFA/UFA+blood 20:4/16:0-PE+blood -0.496240602 0 -0.413333333 serum_fattyacid serum_phospholipids 0.000732 0.00529 dn no up no up up PUFA/UFA+blood 20:4/18:0-PE+blood 0 0 -0.495384615 serum_fattyacid serum_phospholipids 0.000732 0.000755 dn no up up up no PUFA/UFA+blood 20:5/18:0-PC+blood 0 0 0.636239316 serum_fattyacid serum_phospholipids 0.000732 3.97E-06 dn no up no up up PUFA/UFA+blood 22:0/16:0-PE+blood 0 0 0.475555556 serum_fattyacid serum_phospholipids 0.000732 0.091 dn no up no no up PUFA/UFA+blood 22:1-LPA+blood 0 0.519607843 0 serum_fattyacid serum_phospholipids 0.000732 0.00373 dn no up no up up PUFA/UFA+blood 22:6n3+blood 0 0 0.416752137 serum_fattyacid serum_fattyacid 0.000732 0.792 dn no up no no no PUFA/UFA+blood 24:1+blood 0 0 0.535726496 serum_fattyacid serum_fattyacid 0.000732 0.00582 dn no up no dn dn PUFA/UFA+blood 5-HETE+blood 0.492833698 0 0 serum_fattyacid serum_ARA 0.000732 0.697 dn no up no no no PUFA/UFA+blood 8-HETE+blood 0 0.495098039 0 serum_fattyacid serum_ARA 0.000732 0.741 dn no up no no no PUFA/UFA+blood capric acid C6+blood 0 0 0.475555556 serum_fattyacid serum_scfa 0.000732 0.433 dn no up no no no PUFA/UFA+blood CDCA+blood 0 -0.50245098 0 serum_fattyacid serum_bileacids 0.000732 0.506 dn no up no no no PUFA/UFA+blood Choline+blood 0 0.56127451 0 serum_fattyacid serum_choline 0.000732 0.0395 dn no up no up no PUFA/UFA+blood Creatinine+blood 0 0 0.418803419 serum_fattyacid serum_choline 0.000732 0.437 dn no up no no no PUFA/UFA+blood Cysteine+blood 0 0.546568627 0 yes serum_fattyacid serum_aminoacids 0.000732 1.81E-07 dn no up dn up up PUFA/UFA+blood Cystine+blood 0 0.676470588 0 yes serum_fattyacid serum_aminoacids 0.000732 0.00028 dn no up up up no PUFA/UFA+blood d18:1-14:0-SM+blood 0 -0.551470588 0 serum_fattyacid serum_phospholipids 0.000732 0.94 dn no up no no no PUFA/UFA+blood d18:1-14:1-SM+blood 0 -0.575980392 0 serum_fattyacid serum_phospholipids 0.000732 0.0952 dn no up no dn no PUFA/UFA+blood d18:1-16:1-SM+blood 0 0 -0.444102564 serum_fattyacid serum_phospholipids 0.000732 0.2 dn no up no no no PUFA/UFA+blood d18:1-18:0-SM+blood 0.532330827 0 0 serum_fattyacid serum_phospholipids 0.000732 0.97 dn no up no no no PUFA/UFA+blood decanoic acid C10+blood 0 0 0.474871795 serum_fattyacid serum_mcfa 0.000732 6.64E-11 dn no up dn dn no PUFA/UFA+blood DHA+blood 0 0.507352941 0 serum_fattyacid serum_ARA 0.000732 0.872 dn no up no no no PUFA/UFA+blood Ethanolamine+blood 0 0.740196078 0 serum_fattyacid serum_aminoacids 0.000732 0.122 dn no up up no no PUFA/UFA+blood Glycine+blood 0.569924812 0.715686275 0.597264957 serum_fattyacid serum_aminoacids 0.000732 0.00408 dn no up dn no up PUFA/UFA+blood GPC+blood 0 0.50245098 0 serum_fattyacid serum_choline 0.000732 0.00427 dn no up no up up PUFA/UFA+blood GUDCA+blood -0.44962406 0 0 serum_fattyacid serum_bileacids 0.000732 0.0766 dn no up no no dn PUFA/UFA+blood HDCA+blood 0.518101712 0 0 serum_fattyacid serum_bileacids 0.000732 0.483 dn no up no no no PUFA/UFA+blood heptanoic acid C7+blood 0 0 0.416752137 serum_fattyacid serum_mcfa 0.000732 8.27E-11 dn no up dn dn no PUFA/UFA+blood iso-DCA+blood 0.505263158 0 0 serum_fattyacid serum_bileacids 0.000732 0.38 dn no up no no no PUFA/UFA+blood L-Arginine+blood 0 0.573529412 0.593162393 serum_fattyacid serum_aminoacids 0.000732 0.316 dn no up no no no PUFA/UFA+blood L-Asparagine+blood 0 0.676470588 0.677948718 serum_fattyacid serum_aminoacids 0.000732 0.784 dn no up no no no PUFA/UFA+blood L-Aspartic acid+blood 0.589473684 0 0 yes serum_fattyacid serum_aminoacids 0.000732 0.0226 dn no up up up no PUFA/UFA+blood L-Glutamic acid+blood 0 0.595588235 0 yes serum_fattyacid serum_aminoacids 0.000732 6.20E-05 dn no up up up no PUFA/UFA+blood L-Glutamine+blood 0.529323308 0 0.708034188 serum_fattyacid serum_aminoacids 0.000732 0.639 dn no up no no no PUFA/UFA+blood L-Histidine+blood 0.497744361 0.551470588 0.528888889 serum_fattyacid serum_aminoacids 0.000732 0.109 dn no up no no no PUFA/UFA+blood L-Leucine+blood 0 0 0.401025641 yes serum_fattyacid serum_aminoacids 0.000732 3.22E-05 dn no up up up no PUFA/UFA+blood L-Lysine+blood 0 0.674019608 0 yes serum_fattyacid serum_aminoacids 0.000732 0.0107 dn no up no up no PUFA/UFA+blood L-Methionine+blood 0 0.541666667 0 serum_fattyacid serum_aminoacids 0.000732 0.626 dn no up no no no PUFA/UFA+blood L-Phenylalanine+blood 0 0.5 0 yes serum_fattyacid serum_aminoacids 0.000732 0.0103 dn no up up up no PUFA/UFA+blood L-Tryptophan+blood 0 0 0.45982906 serum_fattyacid serum_aminoacids 0.000732 0.164 dn no up no no no PUFA/UFA+blood MUFA%+blood 0.556390977 0.683823529 0.442051282 serum_fattyacid serum_fattyacid 0.000732 0.00142 dn no up up no dn PUFA/UFA+blood n6/n3+blood 0 0.526960784 0 serum_fattyacid serum_fattyacid 0.000732 0.226 dn no up no no no PUFA/UFA+blood octanoic acid C8+blood 0 0 0.643760684 serum_fattyacid serum_mcfa 0.000732 2.84E-11 dn no up dn dn dn PUFA/UFA+blood PUFA/MUFA+blood 0.807518797 0.830882353 0.749059829 serum_fattyacid serum_fattyacid 0.000732 0.00108 dn no up dn no up PUFA%+blood 13-HODE+blood 0 0.578431373 0 serum_fattyacid serum_ARA 0.0013 0.32 dn no up no no no PUFA%+blood 16:0-LPE+blood 0 0 -0.436581197 serum_fattyacid serum_phospholipids 0.0013 0.0711 dn no up up up no PUFA%+blood 16:0/14:0-PC+blood 0.562406015 0 0.462564103 serum_fattyacid serum_phospholipids 0.0013 0.0206 dn no up no up up PUFA%+blood 16:0/16:0-PC+blood 0.553383459 0 0 serum_fattyacid serum_phospholipids 0.0013 0.00079 dn no up no up up PUFA%+blood 16:0/16:0-PI+blood -0.583458647 0 -0.461196581 serum_fattyacid serum_phospholipids 0.0013 0.358 dn no up no no no PUFA%+blood 16:0/16:1-PI+blood -0.720300752 -0.531862745 -0.547350427 serum_fattyacid serum_phospholipids 0.0013 0.262 dn no up no no no PUFA%+blood 16:0/18:0-PC+blood 0 0 0.465299145 serum_fattyacid serum_phospholipids 0.0013 0.521 dn no up no no no PUFA%+blood 16:0/18:1-PC+blood 0.697744361 0 0 serum_fattyacid serum_phospholipids 0.0013 6.15E-07 dn no up up up up PUFA%+blood 16:0/18:1-PE+blood -0.470676692 0 -0.511111111 serum_fattyacid serum_phospholipids 0.0013 0.000107 dn no up up up no PUFA%+blood 16:0/18:2-PC+blood 0.685714286 0.664215686 0.496752137 serum_fattyacid serum_phospholipids 0.0013 3.24E-06 dn no up no up up PUFA%+blood 16:0/18:2-PI+blood -0.52481203 0 -0.42017094 serum_fattyacid serum_phospholipids 0.0013 0.269 dn no up no no no PUFA%+blood 16:0/20:3-PC+blood 0.607518797 0 0.405128205 serum_fattyacid serum_phospholipids 0.0013 5.43E-06 dn no up no up up PUFA%+blood 16:0/20:4-PC+blood 0.64962406 0 0 serum_fattyacid serum_phospholipids 0.0013 0.0262 dn no up no up no PUFA%+blood 16:0/20:4-PE+blood 0 0 -0.526153846 serum_fattyacid serum_phospholipids 0.0013 0.00139 dn no up up up no PUFA%+blood 16:0/20:4-PI+blood -0.645112782 -0.56372549 -0.487179487 serum_fattyacid serum_phospholipids 0.0013 0.558 dn no up no no no PUFA%+blood 16:0/22:0-PE+blood 0 0 0.597264957 serum_fattyacid serum_phospholipids 0.0013 0.00839 dn no up dn no up PUFA%+blood 16:0/22:6-PC+blood 0.463157895 0 0.653333333 serum_fattyacid serum_phospholipids 0.0013 4.53E-05 dn no up no up up PUFA%+blood 16:0/22:6-PE+blood 0 0 -0.436581197 serum_fattyacid serum_phospholipids 0.0013 0.000934 dn no up up up no PUFA%+blood 16:1/16:0-PC+blood 0.636090226 0 0 serum_fattyacid serum_phospholipids 0.0013 0.0215 dn no up no up up PUFA%+blood 16:1/16:1-PC+blood 0.533834586 0 0 serum_fattyacid serum_phospholipids 0.0013 0.0177 dn no up no no up PUFA%+blood 18:0-LPA+blood 0 0.544117647 0 serum_fattyacid serum_phospholipids 0.0013 0.0725 dn no up no dn no PUFA%+blood 18:0-LPE+blood -0.473684211 0 0 serum_fattyacid serum_phospholipids 0.0013 0.491 dn no up no no no PUFA%+blood 18:0/16:0-PC+blood 0.678195489 0.485294118 0 serum_fattyacid serum_phospholipids 0.0013 9.64E-07 dn no up up up up PUFA%+blood 18:0/18:0-PE+blood -0.512781955 0 -0.431111111 serum_fattyacid serum_phospholipids 0.0013 0.00896 dn no up up up no PUFA%+blood 18:0/18:0-PS+blood 0 -0.575980392 0 serum_fattyacid serum_phospholipids 0.0013 0.00617 dn no up no up no PUFA%+blood 18:0/18:1-PE+blood -0.556390977 0 -0.513846154 serum_fattyacid serum_phospholipids 0.0013 0.00716 dn no up up up no PUFA%+blood 18:0/18:1-PG+blood 0 0 -0.645128205 serum_fattyacid serum_phospholipids 0.0013 0.000842 dn no up no up no PUFA%+blood 18:0/18:2-PC+blood 0.639097744 0 0.675213675 serum_fattyacid serum_phospholipids 0.0013 1.74E-06 dn no up no up up PUFA%+blood 18:0/20:2-PC+blood 0 0 0.453675214 serum_fattyacid serum_phospholipids 0.0013 0.733 dn no up no no no PUFA%+blood 18:0/20:4-PC+blood 0.618045113 0 0 serum_fattyacid serum_phospholipids 0.0013 0.454 dn no up no no no PUFA%+blood 18:0/20:5-PC+blood 0.526315789 0 0 serum_fattyacid serum_phospholipids 0.0013 0.17 dn no up no no no PUFA%+blood 18:1-LPE+blood -0.461654135 0 0 serum_fattyacid serum_phospholipids 0.0013 0.117 dn no up no no no PUFA%+blood 18:1/16:0-PC+blood 0.691729323 0.664215686 0.501538462 serum_fattyacid serum_phospholipids 0.0013 2.43E-05 dn no up no up up PUFA%+blood 18:1/16:0-PE+blood -0.473684211 0 -0.664957265 serum_fattyacid serum_phospholipids 0.0013 0.000182 dn no up up up no PUFA%+blood 18:1/16:0-PI+blood -0.536842105 0 0 serum_fattyacid serum_phospholipids 0.0013 0.793 dn no up no no no PUFA%+blood 18:1/16:1-PE+blood -0.509774436 0 -0.587008547 serum_fattyacid serum_phospholipids 0.0013 0.000184 dn no up up up no PUFA%+blood 18:1/18:0-PC+blood 0.663157895 0 0.679316239 serum_fattyacid serum_phospholipids 0.0013 1.83E-06 dn no up no up up PUFA%+blood 18:1/18:0-PE+blood 0 0 -0.575384615 serum_fattyacid serum_phospholipids 0.0013 1.39E-06 dn no up up up no PUFA%+blood 18:1/18:0-PI+blood 0 -0.517156863 0 serum_fattyacid serum_phospholipids 0.0013 0.0931 dn no up no no up PUFA%+blood 18:1/18:1-PC+blood 0.514285714 0 0 serum_fattyacid serum_phospholipids 0.0013 1.34E-05 dn no up no up up PUFA%+blood 18:1/18:1-PE+blood 0 0 -0.535042735 serum_fattyacid serum_phospholipids 0.0013 1.03E-05 dn no up up up no PUFA%+blood 18:1/18:2-PE+blood 0 0 -0.601367521 serum_fattyacid serum_phospholipids 0.0013 0.000293 dn no up up up no PUFA%+blood 18:1/20:4-PC+blood 0.485714286 0 0 serum_fattyacid serum_phospholipids 0.0013 0.582 dn no up no no no PUFA%+blood 18:1/20:4-PE+blood 0 0 -0.517264957 serum_fattyacid serum_phospholipids 0.0013 0.0578 dn no up up no no PUFA%+blood 18:2-LPA+blood 0 0.522058824 0 serum_fattyacid serum_phospholipids 0.0013 0.00684 dn no up dn no up PUFA%+blood 18:2/16:0-PC+blood 0.723308271 0.573529412 0.487179487 serum_fattyacid serum_phospholipids 0.0013 8.67E-05 dn no up no up up PUFA%+blood 18:3/16:0-PE+blood -0.472180451 -0.49754902 -0.695726496 serum_fattyacid serum_phospholipids 0.0013 0.00149 dn no up up up no PUFA%+blood 18:3n6+blood -0.55037594 -0.524509804 0 serum_fattyacid serum_fattyacid 0.0013 0.0463 dn no up up no dn PUFA%+blood 20:0-LPE+blood 0 -0.522058824 0 serum_fattyacid serum_phospholipids 0.0013 0.0615 dn no up no no up PUFA%+blood 20:0/20:4-PE+blood 0 -0.490196078 -0.458461538 serum_fattyacid serum_phospholipids 0.0013 0.00128 dn no up up up no PUFA%+blood 20:1-LPC+blood 0 0 0.541196581 serum_fattyacid serum_phospholipids 0.0013 0.217 dn no up no no no PUFA%+blood 20:1/20:4-PC+blood 0 0 0.500854701 serum_fattyacid serum_phospholipids 0.0013 0.0419 dn no up no no up PUFA%+blood 20:1/20:4-PE+blood 0 -0.485294118 -0.517264957 serum_fattyacid serum_phospholipids 0.0013 0.0042 dn no up up up no PUFA%+blood 20:2-LPC+blood 0 0 0.525470085 serum_fattyacid serum_phospholipids 0.0013 0.119 dn no up no no up PUFA%+blood 20:2/18:1-PE+blood -0.494736842 0 -0.431794872 serum_fattyacid serum_phospholipids 0.0013 0.00208 dn no up up up no PUFA%+blood 20:2+blood 0 0.487745098 0.45982906 serum_fattyacid serum_fattyacid 0.0013 0.478 dn no up no no no PUFA%+blood 20:3/16:0-PC+blood 0.64962406 0 0 serum_fattyacid serum_phospholipids 0.0013 0.00405 dn no up no up up PUFA%+blood 20:3/18:0-PC+blood 0 0 0.595897436 serum_fattyacid serum_phospholipids 0.0013 0.296 dn no up no no no PUFA%+blood 20:3n6+blood -0.44962406 0 0 serum_fattyacid serum_fattyacid 0.0013 0.0884 dn no up up no no PUFA%+blood 20:4-LPA+blood 0 0.62745098 0 serum_fattyacid serum_phospholipids 0.0013 0.398 dn no up no no no PUFA%+blood 20:4/16:0-PE+blood -0.481203008 0 -0.418119658 serum_fattyacid serum_phospholipids 0.0013 0.00529 dn no up no up up PUFA%+blood 20:4/18:0-PE+blood 0 0 -0.435213675 serum_fattyacid serum_phospholipids 0.0013 0.000755 dn no up up up no PUFA%+blood 20:5/18:0-PC+blood 0 0 0.71008547 serum_fattyacid serum_phospholipids 0.0013 3.97E-06 dn no up no up up PUFA%+blood 22:0/16:0-PE+blood 0 0 0.584273504 serum_fattyacid serum_phospholipids 0.0013 0.091 dn no up no no up PUFA%+blood 22:1-LPA+blood 0 0.514705882 0 serum_fattyacid serum_phospholipids 0.0013 0.00373 dn no up no up up PUFA%+blood 22:6n3+blood 0 0 0.457777778 serum_fattyacid serum_fattyacid 0.0013 0.792 dn no up no no no PUFA%+blood 24:1+blood 0 0 0.488547009 serum_fattyacid serum_fattyacid 0.0013 0.00582 dn no up no dn dn PUFA%+blood 5-HETE+blood 0.492078975 0 0 serum_fattyacid serum_ARA 0.0013 0.697 dn no up no no no PUFA%+blood 8-HETE+blood 0 0.553921569 0 serum_fattyacid serum_ARA 0.0013 0.741 dn no up no no no PUFA%+blood Adrenergic signaling in cardiomyocytes 0 -0.502941176 0 serum_fattyacid kegg 0.0013 NA dn no up no no up PUFA%+blood Aldosterone synthesis and secretion 0 -0.529411765 0 serum_fattyacid kegg 0.0013 NA dn no up no up up PUFA%+blood Allograft rejection 0 0.526470588 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Amphetamine addiction 0 -0.614705882 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Apelin signaling pathway 0 -0.511764706 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Apoptosis 0.494736842 0.567647059 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Autoimmune thyroid disease 0 0.526470588 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood B cell receptor signaling pathway 0 0.532352941 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Betaine+blood 0 0 0.45982906 serum_fattyacid serum_choline 0.0013 0.857 dn no up no no no PUFA%+blood Biosynthesis of amino acids 0 0.597058824 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Bladder cancer 0 0.520588235 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Breast cancer 0 0 -0.497692308 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood C-type lectin receptor signaling pathway 0 0.529411765 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood capric acid C6+blood 0 0 0.58017094 serum_fattyacid serum_scfa 0.0013 0.433 dn no up no no no PUFA%+blood Carbon metabolism 0 0 0.404615385 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Cardiac muscle contraction 0 0 -0.440769231 serum_fattyacid kegg 0.0013 NA dn no up no no up PUFA%+blood CDCA+blood 0 -0.522058824 0 serum_fattyacid serum_bileacids 0.0013 0.506 dn no up no no no PUFA%+blood Cell adhesion molecules 0 0.561764706 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Cell cycle 0 -0.747058824 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Cellular senescence 0 0.6 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood cGMP-PKG signaling pathway 0 0.6 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Chagas disease 0 0.502941176 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Chemokine signaling pathway 0 0.573529412 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Choline metabolism in cancer 0 0 -0.436153846 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Choline+blood 0 0.56127451 0 serum_fattyacid serum_choline 0.0013 0.0395 dn no up no up no PUFA%+blood Colorectal cancer 0 -0.547058824 -0.512307692 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Creatinine+blood 0.470676692 0.492647059 0 serum_fattyacid serum_choline 0.0013 0.437 dn no up no no no PUFA%+blood Cysteine+blood 0 0.524509804 0 yes serum_fattyacid serum_aminoacids 0.0013 1.81E-07 dn no up dn up up PUFA%+blood Cystine+blood 0 0.62745098 0 yes serum_fattyacid serum_aminoacids 0.0013 0.00028 dn no up up up no PUFA%+blood Cytosolic DNA-sensing pathway 0.526315789 0 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood d18:1-14:0-SM+blood 0 -0.571078431 0 serum_fattyacid serum_phospholipids 0.0013 0.94 dn no up no no no PUFA%+blood d18:1-14:1-SM+blood 0 -0.62745098 0 serum_fattyacid serum_phospholipids 0.0013 0.0952 dn no up no dn no PUFA%+blood d18:1-18:0-SM+blood 0.593984962 0 0 serum_fattyacid serum_phospholipids 0.0013 0.97 dn no up no no no PUFA%+blood DCA+stool 0 0 -0.49924812 serum_fattyacid stool_bileacids 0.0013 0.195 dn no up no no no PUFA%+blood decanoic acid C10+blood 0 0 0.541196581 serum_fattyacid serum_mcfa 0.0013 6.64E-11 dn no up dn dn no PUFA%+blood DHA+blood 0 0.558823529 0 serum_fattyacid serum_ARA 0.0013 0.872 dn no up no no no PUFA%+blood DPA+blood 0 0.514705882 0 serum_fattyacid serum_ARA 0.0013 0.519 dn no up no no no PUFA%+blood EGFR tyrosine kinase inhibitor resistance 0 -0.538235294 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Endocrine resistance 0 0 -0.414615385 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Endocytosis 0 0.617647059 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Epithelial cell signaling in Helicobacter pylori infection 0.470175439 0.670588235 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood ErbB signaling pathway 0 0 -0.42 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Estrogen signaling pathway 0 -0.502941176 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Ethanolamine+blood 0.452631579 0.727941176 0 serum_fattyacid serum_aminoacids 0.0013 0.122 dn no up up no no PUFA%+blood Fc gamma R-mediated phagocytosis 0 0.567647059 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood GCDCA+blood -0.44962406 0 0 serum_fattyacid serum_bileacids 0.0013 0.31 dn no up no no no PUFA%+blood Glucagon signaling pathway 0 -0.544117647 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Glycine+blood 0.586466165 0.703431373 0.589059829 serum_fattyacid serum_aminoacids 0.0013 0.00408 dn no up dn no up PUFA%+blood Glycolysis / Gluconeogenesis 0 0 0.423846154 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood GPC+blood 0 0.519607843 0 serum_fattyacid serum_choline 0.0013 0.00427 dn no up no up up PUFA%+blood Graft-versus-host disease 0 0.526470588 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood "Growth hormone synthesis, secretion and action" 0 0 -0.483846154 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood GUDCA+blood -0.538345865 0 0 serum_fattyacid serum_bileacids 0.0013 0.0766 dn no up no no dn PUFA%+blood HDCA+blood 0.518101712 0 0 serum_fattyacid serum_bileacids 0.0013 0.483 dn no up no no no PUFA%+blood Hepatitis B 0 0 -0.497692308 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Human papillomavirus infection 0 0.547058824 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood IL-17 signaling pathway 0 0.573529412 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Inflammatory mediator regulation of TRP channels 0 -0.511764706 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Influenza A 0.528070175 0 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Insulin signaling pathway 0 -0.547058824 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood iso-DCA+blood 0.578947368 0 0 serum_fattyacid serum_bileacids 0.0013 0.38 dn no up no no no PUFA%+blood L-Arginine+blood 0 0.56127451 0.552820513 serum_fattyacid serum_aminoacids 0.0013 0.316 dn no up no no no PUFA%+blood L-Asparagine+blood 0 0.68627451 0.651965812 serum_fattyacid serum_aminoacids 0.0013 0.784 dn no up no no no PUFA%+blood L-Aspartic acid+blood 0.563909774 0 0 yes serum_fattyacid serum_aminoacids 0.0013 0.0226 dn no up up up no PUFA%+blood L-Glutamic acid+blood 0 0.610294118 0 yes serum_fattyacid serum_aminoacids 0.0013 6.20E-05 dn no up up up no PUFA%+blood L-Glutamine+blood 0.539849624 0 0.757948718 serum_fattyacid serum_aminoacids 0.0013 0.639 dn no up no no no PUFA%+blood L-Histidine+blood 0.509774436 0.524509804 0.439316239 serum_fattyacid serum_aminoacids 0.0013 0.109 dn no up no no no PUFA%+blood L-Lysine+blood 0 0.625 0 yes serum_fattyacid serum_aminoacids 0.0013 0.0107 dn no up no up no PUFA%+blood L-Methionine+blood 0 0.524509804 0 serum_fattyacid serum_aminoacids 0.0013 0.626 dn no up no no no PUFA%+blood L-Phenylalanine+stool 0 0 0.502255639 serum_fattyacid stool_cometabolism 0.0013 0.398 dn no up no no no PUFA%+blood L-Tryptophan+blood 0 0 0.433162393 serum_fattyacid serum_aminoacids 0.0013 0.164 dn no up no no no PUFA%+blood L-Tyrosine+stool 0.587912088 0 0.551879699 serum_fattyacid stool_cometabolism 0.0013 0.44 dn no up no no no PUFA%+blood lauric acid C12+blood 0.473684211 0 0 serum_fattyacid serum_mcfa 0.0013 0.015 dn no up no dn dn PUFA%+blood Lipid and atherosclerosis 0 0.758823529 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Long-term potentiation 0 -0.555882353 0 serum_fattyacid kegg 0.0013 NA dn no up no no up PUFA%+blood Longevity regulating pathway - multiple species -0.557894737 0 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood MicroRNAs in cancer 0 0 -0.483076923 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood mRNA surveillance pathway 0 -0.747058824 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood mTOR signaling pathway 0 -0.532352941 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood MUFA%+blood 0.643609023 0.708333333 0.495384615 serum_fattyacid serum_fattyacid 0.0013 0.00142 dn no up up no dn PUFA%+blood n6/n3+blood 0 0.50245098 0 serum_fattyacid serum_fattyacid 0.0013 0.226 dn no up no no no PUFA%+blood Natural killer cell mediated cytotoxicity 0 0.597058824 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Neuroactive ligand-receptor interaction 0 0.502941176 0 serum_fattyacid kegg 0.0013 NA dn no up up up up PUFA%+blood Neutrophil extracellular trap formation 0 0.523529412 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood NOD-like receptor signaling pathway 0 0.617647059 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood octanoic acid C8+blood 0 0 0.668376068 serum_fattyacid serum_mcfa 0.0013 2.84E-11 dn no up dn dn dn PUFA%+blood Olfactory transduction 0 0.576470588 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Oocyte meiosis 0 -0.579411765 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Osteoclast differentiation 0 0.573529412 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Pancreatic cancer 0 0 -0.411538462 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Pathogenic Escherichia coli infection 0 0.652941176 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Pertussis 0 0.605882353 0 serum_fattyacid kegg 0.0013 NA dn no up no no dn PUFA%+blood Phagosome 0 0.573529412 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Phosphatidylinositol signaling system 0 -0.523529412 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Prevotella -0.584713542 0 0 acetate-producing serum_fattyacid Genus 0.0013 0.287 dn no up no no no PUFA%+blood Propionic acid+stool 0 0 -0.473684211 yes serum_fattyacid stool_scfa 0.0013 0.0436 dn no up dn no up PUFA%+blood Protein processing in endoplasmic reticulum 0 -0.685294118 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Proteoglycans in cancer 0 -0.547058824 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood PUFA/MUFA+blood 0.730827068 0.816176471 0.688888889 serum_fattyacid serum_fattyacid 0.0013 0.00108 dn no up dn no up PUFA%+blood PUFA/UFA+blood 0.971428571 0.990196078 0.932991453 serum_fattyacid serum_fattyacid 0.0013 0.000732 dn no up dn no up PUFA%+blood Ras signaling pathway 0 -0.682352941 0 yes serum_fattyacid kegg 0.0013 NA dn no up no up up PUFA%+blood Rheumatoid arthritis 0 0.561764706 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Ribosome biogenesis in eukaryotes 0 -0.576470588 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood RNA degradation 0 -0.605882353 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood RNA transport 0 -0.508823529 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Salmonella infection 0 0.511764706 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Spinocerebellar ataxia 0 -0.620588235 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood TCA+stool -0.629986841 0 0 serum_fattyacid stool_bileacids 0.0013 0.458 dn no up no no no PUFA%+blood Th1 and Th2 cell differentiation 0.464912281 0 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Toll-like receptor signaling pathway 0 0.602941176 0 yes serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Transcriptional misregulation in cancer 0 0 -0.617692308 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Tuberculosis 0 0.523529412 0 serum_fattyacid kegg 0.0013 NA dn no up no no dn PUFA%+blood Type I diabetes mellitus 0 0.526470588 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Viral carcinogenesis 0 0.597058824 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Wnt signaling pathway 0 -0.705882353 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA%+blood Yersinia infection 0 0.582352941 0 serum_fattyacid kegg 0.0013 NA dn no up no no no PUFA+blood 12-HEPE+blood -0.522488056 0 0 serum_fattyacid serum_ARA 0.212 0.312 no no no no no no PUFA+blood 12-ketoDCA+blood -0.494738073 0 0 serum_fattyacid serum_bileacids 0.212 0.517 no no no no no no PUFA+blood 14:0/18:2-PC+blood 0 0 0.414017094 serum_fattyacid serum_phospholipids 0.212 0.102 no no no no up no PUFA+blood 14:0+blood 0.619548872 0 0.523418803 yes serum_fattyacid serum_fattyacid 0.212 0.00572 no no no up no dn PUFA+blood 16:0/16:0-PI+blood 0 -0.529411765 0 serum_fattyacid serum_phospholipids 0.212 0.358 no no no no no no PUFA+blood 16:0/18:0-PC+blood 0 0 0.40034188 serum_fattyacid serum_phospholipids 0.212 0.521 no no no no no no PUFA+blood 16:0/20:4-PI+blood 0 -0.49754902 0 serum_fattyacid serum_phospholipids 0.212 0.558 no no no no no no PUFA+blood 16:0/20:5-PG+blood 0 0 -0.402393162 serum_fattyacid serum_phospholipids 0.212 0.00656 no no no no up no PUFA+blood 16:0+blood 0.876691729 0.828431373 0.646495726 yes serum_fattyacid serum_fattyacid 0.212 0.00876 no no no up no no PUFA+blood 16:1/18:2-PG+blood 0 0 -0.423589744 serum_fattyacid serum_phospholipids 0.212 1.40E-08 no no no no up up PUFA+blood 16:1+blood 0.631578947 0 0 yes serum_fattyacid serum_fattyacid 0.212 0.0186 no no no no no dn PUFA+blood 18:0/20:4-PI+blood 0 0.5 0 serum_fattyacid serum_phospholipids 0.212 0.167 no no no no no no PUFA+blood 18:0+blood 0.778947368 0.742647059 0.625299145 serum_fattyacid serum_fattyacid 0.212 0.344 no no no no no no PUFA+blood 18:1/18:0-PS+blood 0 0.632352941 0 serum_fattyacid serum_phospholipids 0.212 0.193 no no no no no no PUFA+blood 18:1/18:1-PG+blood 0 0 -0.502905983 serum_fattyacid serum_phospholipids 0.212 0.00352 no no no no up up PUFA+blood 18:1+blood 0.735338346 0.534313725 0.43042735 yes serum_fattyacid serum_fattyacid 0.212 0.00202 no no no up no dn PUFA+blood 18:2/16:0-PC+blood 0 0.517156863 0 serum_fattyacid serum_phospholipids 0.212 8.67E-05 no no no no up up PUFA+blood 18:2n6c+blood 0.706766917 0.789215686 0.798974359 serum_fattyacid serum_fattyacid 0.212 0.15 no no no no no no PUFA+blood 18:3n3+blood 0.616541353 0 0.401025641 serum_fattyacid serum_fattyacid 0.212 0.291 no no no no no no PUFA+blood 20:1-LPA+blood 0 0 -0.450940171 serum_fattyacid serum_phospholipids 0.212 0.0187 no no no dn dn no PUFA+blood 20:2/18:3-PE+blood 0 0.531862745 0 serum_fattyacid serum_phospholipids 0.212 0.0391 no no no up up no PUFA+blood 20:3/16:0-PC+blood 0 0.490196078 0 serum_fattyacid serum_phospholipids 0.212 0.00405 no no no no up up PUFA+blood 20:3/18:0-PC+blood 0.521804511 0 0 serum_fattyacid serum_phospholipids 0.212 0.296 no no no no no no PUFA+blood 20:4-LPE+blood 0 0.526960784 0 serum_fattyacid serum_phospholipids 0.212 0.552 no no no no no no PUFA+blood 20:4/18:0-PE+blood 0 0.490196078 0 serum_fattyacid serum_phospholipids 0.212 0.000755 no no no up up no PUFA+blood 20:4n6+blood 0 0.612745098 0 serum_fattyacid serum_fattyacid 0.212 0.133 no no no no no no PUFA+blood 22:6n3+blood 0.488721805 0 0 serum_fattyacid serum_fattyacid 0.212 0.792 no no no no no no PUFA+blood 24:1+blood 0 0.482843137 0 serum_fattyacid serum_fattyacid 0.212 0.00582 no no no no dn dn PUFA+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0.587912088 0 0 serum_fattyacid stool_cometabolism 0.212 0.33 no no no no no no PUFA+blood AA+blood 0.497744361 0 0 serum_fattyacid serum_ARA 0.212 0.212 no no no no no no PUFA+blood Adipocytokine signaling pathway 0 0 0.445384615 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood AGE-RAGE signaling pathway in diabetic complications 0.512280702 0 0 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Alzheimer disease 0 0 -0.51 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood AMPK signaling pathway 0 0 0.461538462 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Arachidonic acid metabolism 0 0 0.406923077 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Bifidobacterium 0 -0.657265605 0 acetate-producing serum_fattyacid Genus 0.212 0.105 no no no no dn no PUFA+blood Biosynthesis of cofactors 0 0 0.636923077 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood butyric acid C4+blood 0.505263158 0 0 serum_fattyacid serum_scfa 0.212 0.407 no no no no no no PUFA+blood Cardiac muscle contraction 0 0 -0.515384615 serum_fattyacid kegg 0.212 NA no no no no no up PUFA+blood DCA+blood -0.515789474 0 0 serum_fattyacid serum_bileacids 0.212 0.122 no no no no no no PUFA+blood Diabetic cardiomyopathy 0 0 -0.446923077 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood DMG+blood 0 -0.553921569 0 serum_fattyacid serum_choline 0.212 0.909 no no no no no no PUFA+blood EPA+blood 0.461654135 0 0 serum_fattyacid serum_ARA 0.212 0.212 no no no no no no PUFA+blood GCDCA+blood 0 0 -0.511111111 serum_fattyacid serum_bileacids 0.212 0.31 no no no no no no PUFA+blood GLCA+blood 0 0 -0.477393357 serum_fattyacid serum_bileacids 0.212 0.319 no no no no no no PUFA+blood Glutathione metabolism 0 0 0.561538462 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood "Glycine, serine and threonine metabolism" 0 -0.567647059 0.595384615 serum_fattyacid kegg 0.212 NA no no no no up no PUFA+blood GUDCA+blood 0 0 -0.404444444 serum_fattyacid serum_bileacids 0.212 0.0766 no no no no no dn PUFA+blood iso-DCA+blood 0 0 0.42017094 serum_fattyacid serum_bileacids 0.212 0.38 no no no no no no PUFA+blood isovaleric acid iso-C5+blood 0 0.546568627 0 serum_fattyacid serum_scfa 0.212 0.117 no no no no no no PUFA+blood Kaposi sarcoma-associated herpesvirus infection -0.470175439 0 0 serum_fattyacid kegg 0.212 NA no no no no no dn PUFA+blood L-Proline+blood -0.469172932 0 -0.424957265 yes serum_fattyacid serum_aminoacids 0.212 0.00265 no no no up up no PUFA+blood Lipid and atherosclerosis 0.489473684 0 0 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Longevity regulating pathway 0 0 0.475384615 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Malaria 0 0 0.416153846 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood MicroRNAs in cancer 0 0 -0.417692308 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Mitophagy - animal -0.470175439 0 0 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood MUFA+blood 0.74887218 0.546568627 0.419487179 serum_fattyacid serum_fattyacid 0.212 0.00175 no no no up no dn PUFA+blood n3+blood 0 0.514705882 0 serum_fattyacid serum_fattyacid 0.212 0.806 no no no no no no PUFA+blood n6+blood 0.867669173 0.953431373 0.940512821 serum_fattyacid serum_fattyacid 0.212 0.153 no no no no no no PUFA+blood NOD-like receptor signaling pathway 0.459649123 0 0 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Oxidative phosphorylation 0 0 -0.430769231 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Parkinson disease -0.531578947 0 0 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Pathways of neurodegeneration - multiple diseases -0.540350877 0 0 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Pertussis 0.566666667 0 0 serum_fattyacid kegg 0.212 NA no no no no no dn PUFA+blood Porphyrin and chlorophyll metabolism 0 -0.588235294 0.627692308 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Prevotella 0 0.528252371 0 acetate-producing serum_fattyacid Genus 0.212 0.287 no no no no no no PUFA+blood Prion disease 0 0 -0.428461538 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Progesterone-mediated oocyte maturation 0 0 -0.407692308 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Purine metabolism 0 0 0.441538462 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Retrograde endocannabinoid signaling 0 0 -0.431538462 serum_fattyacid kegg 0.212 NA no no no no no up PUFA+blood Ruminococcus 0 -0.602941176 0 acetate-producing serum_fattyacid Genus 0.212 0.335 no no no no no no PUFA+blood Shigellosis -0.615789474 0 0 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Sphingolipid signaling pathway 0 0 -0.567692308 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Tuberculosis 0.457894737 0 0 serum_fattyacid kegg 0.212 NA no no no no no dn PUFA+blood Ubiquitin mediated proteolysis -0.507017544 0 0.408461538 serum_fattyacid kegg 0.212 NA no no no no no no PUFA+blood Wnt signaling pathway 0 0 -0.408461538 serum_fattyacid kegg 0.212 NA no no no no no no Purine metabolism Fatty acid biosynthesis 0 -0.43972332 0 kegg kegg NA NA no no no no no no Purine metabolism Galactose metabolism 0 -0.41798419 0 kegg kegg NA NA no no no no no no Purine metabolism Oxidative phosphorylation 0 0.41798419 0 kegg kegg NA NA no no no no no no Purine metabolism Pentose and glucuronate interconversions 0 0 -0.435778636 kegg kegg NA NA no no no no no no Purine metabolism Pentose phosphate pathway 0 -0.668972332 0 kegg kegg NA NA no no no no no no Purine metabolism Synthesis and degradation of ketone bodies 0 0.461462451 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Arginine biosynthesis 0 -0.659090909 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Ascorbate and aldarate metabolism 0 0.429841897 0.423423423 kegg kegg NA NA no no no no no no Pyrimidine metabolism Citrate cycle (TCA cycle) 0.585217391 0.688735178 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Fatty acid biosynthesis 0 -0.652173913 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Fatty acid degradation 0.631304348 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Fatty acid elongation 0.666956522 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Fructose and mannose metabolism 0.709565217 0 0.437837838 kegg kegg NA NA no no no no no no Pyrimidine metabolism Galactose metabolism 0.729565217 0 0.487516088 kegg kegg NA NA no no no no no no Pyrimidine metabolism Glycolysis / Gluconeogenesis 0.717391304 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Oxidative phosphorylation -0.707826087 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Pentose and glucuronate interconversions 0 0.726284585 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Pentose phosphate pathway 0 -0.532608696 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Primary bile acid biosynthesis 0.688695652 0 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Purine metabolism 0 0.533596838 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Steroid biosynthesis 0 0.614624506 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Steroid hormone biosynthesis 0.52 0.652173913 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Synthesis and degradation of ketone bodies 0.540869565 0.707509881 0 kegg kegg NA NA no no no no no no Pyrimidine metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.746086957 0.77173913 0 kegg kegg NA NA no no no no no no Pyruvate metabolism "Alanine, aspartate and glutamate metabolism" 0 -0.663043478 0 kegg kegg NA NA no no no no no no Pyruvate metabolism alpha-Linolenic acid metabolism 0.442608696 -0.481225296 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Amino sugar and nucleotide sugar metabolism 0.622608696 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Arginine and proline metabolism 0 -0.707509881 0 kegg kegg NA NA no no no no up no Pyruvate metabolism Arginine biosynthesis 0 -0.664031621 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Ascorbate and aldarate metabolism 0.500869565 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism beta-Alanine metabolism 0.566956522 0.541501976 0.558558559 kegg kegg NA NA no no no no no no Pyruvate metabolism Citrate cycle (TCA cycle) 0.833913043 0.872529644 0.474903475 kegg kegg NA NA no no no no no no Pyruvate metabolism Cysteine and methionine metabolism 0.913913043 0.969367589 0.806949807 kegg kegg NA NA no no no no no no Pyruvate metabolism Fatty acid biosynthesis 0 -0.671936759 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Fatty acid degradation 0.413913043 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Fatty acid elongation 0.517391304 0.600790514 0.632689833 kegg kegg NA NA no no no no no no Pyruvate metabolism Fructose and mannose metabolism 0 -0.537549407 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Galactose metabolism 0 -0.486166008 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Glutathione metabolism 0 0.672924901 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Glycerolipid metabolism 0 -0.433794466 0 kegg kegg NA NA no no no no no up Pyruvate metabolism "Glycine, serine and threonine metabolism" 0 0.456521739 0 kegg kegg NA NA no no no no up no Pyruvate metabolism Glycolysis / Gluconeogenesis 0.657391304 0.81027668 0.440926641 kegg kegg NA NA no no no no no no Pyruvate metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.852766798 -0.593822394 kegg kegg NA NA no no no no no no Pyruvate metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.468695652 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Glycosaminoglycan degradation -0.52173913 -0.522727273 -0.401029601 kegg kegg NA NA no no no no no up Pyruvate metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.575652174 -0.577075099 -0.403346203 kegg kegg NA NA no no no no no no Pyruvate metabolism Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.431304348 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Histidine metabolism 0.520869565 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Mannose type O-glycan biosynthesis -0.433913043 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Mucin type O-glycan biosynthesis 0.610434783 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism N-Glycan biosynthesis 0 0.713438735 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Other glycan degradation 0 -0.415019763 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Oxidative phosphorylation 0 0.557312253 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Pentose and glucuronate interconversions 0.740869565 0.81916996 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Pentose phosphate pathway 0 -0.516798419 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Phenylalanine metabolism 0.520869565 0.665019763 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Primary bile acid biosynthesis 0.834782609 0.632411067 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Pyrimidine metabolism 0.557391304 0.606719368 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Sphingolipid metabolism -0.542608696 0 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Starch and sucrose metabolism 0 -0.626482213 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Steroid biosynthesis 0 0.690711462 0.523294723 kegg kegg NA NA no no no no no no Pyruvate metabolism Steroid hormone biosynthesis 0.66173913 0.618577075 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Synthesis and degradation of ketone bodies 0.894782609 0.727272727 0.577348777 kegg kegg NA NA no no no no no no Pyruvate metabolism Taurine and hypotaurine metabolism 0 -0.520750988 0 kegg kegg NA NA no no no no no no Pyruvate metabolism Tryptophan metabolism 0.765217391 0.704545455 0.586100386 kegg kegg NA NA no no no no up no Pyruvate metabolism Tyrosine metabolism 0.771304348 0.799407115 0.681338481 kegg kegg NA NA no no no no no no Pyruvate metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.780869565 0.662055336 0.588416988 kegg kegg NA NA no no no no no no Pyruvate metabolism "Valine, leucine and isoleucine degradation" 0.87826087 0.759881423 0.711711712 kegg kegg NA NA no no no no no no Pyruvate metabolism Various types of N-glycan biosynthesis 0 0.591897233 0 kegg kegg NA NA no no no no no no RANTES 12-ketoDCA+blood 0 0.592268575 0 yes serum_cytokines serum_bileacids 0.0757 0.517 no no up no no no RANTES 16:1/18:2-PG+blood 0 -0.514285714 0 yes serum_cytokines serum_phospholipids 0.0757 1.40E-08 no no up no up up RANTES 18:0-LPE+blood 0 0 0.612030075 yes serum_cytokines serum_phospholipids 0.0757 0.491 no no up no no no RANTES 18:0/20:3-PI+blood 0 -0.517857143 0 yes serum_cytokines serum_phospholipids 0.0757 0.377 no no up no no no RANTES 18:3/18:2-PC+blood 0 0 0.523308271 yes serum_cytokines serum_phospholipids 0.0757 0.0394 no no up no no up RANTES 20:1+blood 0 0 -0.460150376 yes yes serum_cytokines serum_fattyacid 0.0757 2.56E-05 no no up dn dn dn RANTES 22:6n3+blood 0.709090909 0 0 yes serum_cytokines serum_fattyacid 0.0757 0.792 no no up no no no RANTES Alzheimer disease -0.604395604 0 0.517241379 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Amyotrophic lateral sclerosis -0.686813187 0 0.487684729 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Antigen processing and presentation 0 -0.470676692 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Arginine and proline metabolism 0 0 -0.507936508 yes serum_cytokines kegg 0.0757 NA no no up no up no RANTES Asthma 0 -0.485714286 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Bacterial invasion of epithelial cells 0 -0.484210526 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Bacteroides 0.648351648 0 0 yes LPS-producing serum_cytokines Genus 0.0757 0.000267 no no up dn dn up RANTES C-type lectin receptor signaling pathway -0.571428571 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES CA+blood 0 0 0.486377594 yes serum_cytokines serum_bileacids 0.0757 0.606 no no up no no no RANTES CA+stool 0 -0.699300699 0 yes serum_cytokines stool_bileacids 0.0757 0.827 no no up no no no RANTES Carbon metabolism 0 -0.539849624 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Cardiac muscle contraction -0.615384615 0 0.464696223 yes serum_cytokines kegg 0.0757 NA no no up no no up RANTES CDCA+stool 0 -0.622377622 0 yes serum_cytokines stool_bileacids 0.0757 0.663 no no up no no no RANTES Chemical carcinogenesis - receptor activation 0 0.530827068 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Chronic myeloid leukemia -0.576923077 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Clostridium 0 -0.456437317 0 yes serum_cytokines Genus 0.0757 0.925 no no up no no no RANTES Cysteine+blood 0 0 -0.572932331 yes yes serum_cytokines serum_aminoacids 0.0757 1.81E-07 no no up dn up up RANTES Cytosolic DNA-sensing pathway -0.571428571 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Diabetic cardiomyopathy -0.587912088 0 0.431308155 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES DPA+blood 0 0 -0.44962406 yes serum_cytokines serum_ARA 0.0757 0.519 no no up no no no RANTES Epstein-Barr virus infection 0 -0.452631579 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES ErbB signaling pathway 0 0.515789474 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Faecalibacterium -0.67032967 0 0 yes butyrate-producing serum_cytokines Genus 0.0757 0.0039 no no up no dn dn RANTES GCA+stool 0 -0.678321678 0 yes serum_cytokines stool_bileacids 0.0757 0.0809 no no up no no no RANTES Glycolysis / Gluconeogenesis 0 -0.494736842 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES GM-CSF 0 0 -0.44160178 yes yes serum_cytokines serum_cytokines 0.0757 0.0124 no no up up no no RANTES Hepatitis C -0.576923077 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Huntington disease 0 0 0.462506842 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES IFN-g -0.71978022 -0.714285714 -0.439377086 yes serum_cytokines serum_cytokines 0.0757 0.825 no no up no no no RANTES IL-13 0 0 -0.749499444 yes yes serum_cytokines serum_cytokines 0.0757 0.00264 no no up up up no RANTES IL-17 signaling pathway 0 0 -0.425834702 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES IL-17A -0.598901099 0 0 yes serum_cytokines serum_cytokines 0.0757 0.855 no no up no no no RANTES IL-1b 0.664835165 0 -0.510567297 yes yes serum_cytokines serum_cytokines 0.0757 0.00358 no no up up up no RANTES IL-2 0 -0.515584416 0 yes serum_cytokines serum_cytokines 0.0757 0.522 no no up no no no RANTES IL-6 0 -0.7 0 yes serum_cytokines serum_cytokines 0.0757 0.52 no no up no no no RANTES IL-9 0 0.794805195 0 yes serum_cytokines serum_cytokines 0.0757 0.906 no no up no no no RANTES Insulin resistance -0.56043956 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES IP-10 0.697802198 0 0 yes serum_cytokines serum_cytokines 0.0757 0.394 no no up no no no RANTES iso-DCA+blood 0 0 -0.452631579 yes serum_cytokines serum_bileacids 0.0757 0.38 no no up no no no RANTES iso-LCA+blood 0 0.69102029 0 yes serum_cytokines serum_bileacids 0.0757 0.507 no no up no no no RANTES iso-LCA+stool 0 0.692307692 0 yes serum_cytokines stool_bileacids 0.0757 0.72 no no up no no no RANTES L-Aspartic acid+blood 0 0 -0.466165414 yes yes serum_cytokines serum_aminoacids 0.0757 0.0226 no no up up up no RANTES L-Histidine+blood 0 0 -0.6 yes serum_cytokines serum_aminoacids 0.0757 0.109 no no up no no no RANTES L-Homocystine+blood 0 0.585714286 0 yes serum_cytokines serum_aminoacids 0.0757 0.197 no no up no no no RANTES L-Isoleucine+blood 0 -0.6 -0.508270677 yes yes serum_cytokines serum_aminoacids 0.0757 5.47E-06 no no up up up no RANTES L-Leucine+blood 0 0 -0.521804511 yes yes serum_cytokines serum_aminoacids 0.0757 3.22E-05 no no up up up no RANTES L-Ornithine+blood 0 0 -0.527819549 yes serum_cytokines serum_aminoacids 0.0757 0.175 no no up no no no RANTES L-Phenylalanine+blood 0 0 -0.565413534 yes yes serum_cytokines serum_aminoacids 0.0757 0.0103 no no up up up no RANTES L-Phenylalanine+stool 0 0 -0.509803922 yes serum_cytokines stool_cometabolism 0.0757 0.398 no no up no no no RANTES L-Tryptophan+urine -0.733333333 0 0 yes serum_cytokines urine_cometabolism 0.0757 0.226 no no up no no no RANTES L-Tyrosine+blood 0 0 -0.521804511 yes yes serum_cytokines serum_aminoacids 0.0757 0.00913 no no up up up no RANTES L-Tyrosine+stool 0 0 -0.539215686 yes serum_cytokines stool_cometabolism 0.0757 0.44 no no up no no no RANTES L-Tyrosine+urine -0.757575758 0 0 yes serum_cytokines urine_cometabolism 0.0757 0.45 no no up no no no RANTES LCA+stool 0 0.671328671 0 yes serum_cytokines stool_bileacids 0.0757 0.314 no no up no no no RANTES Leishmaniasis 0 -0.535338346 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Leukocyte transendothelial migration 0 -0.54887218 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Lysosome 0 -0.445112782 -0.413245758 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Measles 0 0 -0.407772304 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES MIP-1b 0 0.711688312 0.498553949 yes serum_cytokines serum_cytokines 0.0757 0.632 no no up no no no RANTES Neurotrophin signaling pathway -0.686813187 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Non-alcoholic fatty liver disease -0.604395604 0 0.403940887 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Non-small cell lung cancer 0 0.566917293 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES nutriCA+stool 0 -0.767624669 0 yes serum_cytokines stool_bileacids 0.0757 0.481 no no up no no no RANTES Oxidative phosphorylation -0.593406593 0 0.432402846 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES p53 signaling pathway 0 0.589473684 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES "Parathyroid hormone synthesis, secretion and action" -0.659340659 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Parkinson disease -0.631868132 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Pathways in cancer 0 0.497744361 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Pathways of neurodegeneration - multiple diseases -0.631868132 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES PD-L1 expression and PD-1 checkpoint pathway in cancer -0.56043956 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES PDGF-bb 0 0 0.54705228 yes yes serum_cytokines serum_cytokines 0.0757 0.111 no no up no no no RANTES PI3K-Akt signaling pathway -0.741758242 0 0 yes yes serum_cytokines kegg 0.0757 NA no no up no up up RANTES Platinum drug resistance 0 0.463157895 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Prion disease -0.582417582 0 0.435686918 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Progesterone-mediated oocyte maturation 0 0.470676692 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Propionic acid+stool 0 0 0.644607843 yes yes serum_cytokines stool_scfa 0.0757 0.0436 no no up dn no up RANTES Prostate cancer -0.675824176 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Relaxin signaling pathway -0.648351648 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Retrograde endocannabinoid signaling 0 0 0.527093596 yes serum_cytokines kegg 0.0757 NA no no up no no up RANTES Sarcosine+blood 0 0 -0.461654135 yes serum_cytokines serum_choline 0.0757 5.06E-05 no no up up up no RANTES Serine+blood 0 0 -0.520300752 yes serum_cytokines serum_aminoacids 0.0757 0.942 no no up no no no RANTES SFA%+blood 0 0 -0.497744361 yes serum_cytokines serum_fattyacid 0.0757 0.0236 no no up no up no RANTES Signaling pathways regulating pluripotency of stem cells -0.554945055 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES Spliceosome 0 0.521804511 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES T cell receptor signaling pathway -0.692307692 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES TCA+stool 0 -0.630473822 0 yes serum_cytokines stool_bileacids 0.0757 0.458 no no up no no no RANTES TDCA+stool 0 -0.637111543 0 yes serum_cytokines stool_bileacids 0.0757 0.963 no no up no no no RANTES Thermogenesis -0.598901099 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES TNF signaling pathway -0.631868132 0 0 yes serum_cytokines kegg 0.0757 NA no no up no no no RANTES TXB2+blood 0.747723819 0 0 yes yes serum_cytokines serum_ARA 0.0757 0.0644 no no up dn no no RANTES UDCA+stool 0 -0.615384615 0 yes serum_cytokines stool_bileacids 0.0757 0.266 no no up no no no RANTES Valine+blood 0 0 -0.559398496 yes yes serum_cytokines serum_aminoacids 0.0757 1.22E-06 no no up up up no Rap1 signaling pathway ABC transporters 0 -0.555335968 0 kegg kegg NA NA no no no no up up Rap1 signaling pathway "Alanine, aspartate and glutamate metabolism" 0 -0.444664032 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Alistipes 0 -0.484399702 0 kegg Genus NA 0.0114 no no no no up no Rap1 signaling pathway Anaerostipes 0 -0.419642491 0 butyrate-producing kegg Genus NA 0.568 no no no no no no Rap1 signaling pathway Basal transcription factors -0.77826087 0 -0.577348777 kegg kegg NA NA no no no no no no Rap1 signaling pathway Base excision repair -0.802608696 -0.425889328 -0.440926641 kegg kegg NA NA no no no no no no Rap1 signaling pathway Butyricicoccus -0.430856054 0 0 butyrate-producing kegg Genus NA 0.852 no no no no no no Rap1 signaling pathway DNA replication -0.539130435 0 -0.41003861 kegg kegg NA NA no no no no no no Rap1 signaling pathway Drug metabolism - other enzymes 0 0.424901186 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway EGFR tyrosine kinase inhibitor resistance -0.489565217 0 -0.418790219 kegg kegg NA NA no no no no no no Rap1 signaling pathway Fanconi anemia pathway -0.566956522 -0.46541502 -0.506821107 kegg kegg NA NA no no no no no no Rap1 signaling pathway Fatty acid degradation 0 -0.47826087 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Glycerolipid metabolism 0 -0.498023715 0 kegg kegg NA NA no no no no no up Rap1 signaling pathway Glycerophospholipid metabolism -0.54 -0.602766798 -0.406435006 kegg kegg NA NA no no no no no up Rap1 signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.410434783 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Glycosaminoglycan degradation 0.471304348 0 0 kegg kegg NA NA no no no no no up Rap1 signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.420869565 -0.438735178 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Homologous recombination -0.512173913 -0.668972332 -0.542084942 kegg kegg NA NA no no no no no no Rap1 signaling pathway Inositol phosphate metabolism 0 -0.591897233 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Lachnospira 0 0.582653835 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Rap1 signaling pathway Lysine degradation -0.554782609 -0.488142292 -0.458687259 kegg kegg NA NA no no no no no no Rap1 signaling pathway MAPK signaling pathway 0 -0.719367589 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Mucin type O-glycan biosynthesis 0 -0.734189723 -0.484427284 kegg kegg NA NA no no no no no no Rap1 signaling pathway N-Glycan biosynthesis -0.426956522 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Nucleotide excision repair -0.566956522 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Oscillospira 0 -0.444664032 0 LPS-producing kegg Genus NA 0.62 no no no no no no Rap1 signaling pathway Other glycan degradation 0 -0.422924901 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Other types of O-glycan biosynthesis -0.560869565 -0.510869565 -0.503732304 kegg kegg NA NA no no no no no no Rap1 signaling pathway Oxidative phosphorylation 0 0.462450593 0.419305019 kegg kegg NA NA no no no no no no Rap1 signaling pathway Pentose phosphate pathway 0.475652174 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Phenylalanine metabolism 0.417391304 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Platinum drug resistance -0.788695652 -0.660079051 -0.483397683 kegg kegg NA NA no no no no no no Rap1 signaling pathway Proteasome -0.448695652 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Protein export -0.56173913 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Pyrimidine metabolism 0 0 -0.551866152 kegg kegg NA NA no no no no no no Rap1 signaling pathway Ribosome biogenesis in eukaryotes -0.716521739 0 -0.482110682 kegg kegg NA NA no no no no no no Rap1 signaling pathway RNA degradation 0 0 -0.429086229 kegg kegg NA NA no no no no no no Rap1 signaling pathway RNA polymerase -0.753043478 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway RNA transport -0.464347826 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Selenocompound metabolism -0.763478261 -0.553359684 -0.525096525 kegg kegg NA NA no no no no no no Rap1 signaling pathway Sphingolipid metabolism 0.414782609 0.438735178 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Spliceosome -0.80173913 -0.730237154 -0.548262548 kegg kegg NA NA no no no no no no Rap1 signaling pathway Taurine and hypotaurine metabolism -0.477391304 -0.470355731 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Terpenoid backbone biosynthesis -0.526956522 0 0 kegg kegg NA NA no no no no no no Rap1 signaling pathway Thiamine metabolism 0 0 -0.491119691 kegg kegg NA NA no no no no no no Rap1 signaling pathway Various types of N-glycan biosynthesis -0.470434783 0 0 kegg kegg NA NA no no no no no no Ras signaling pathway 2-Oxocarboxylic acid metabolism 0 0.632411067 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway "Alanine, aspartate and glutamate metabolism" -0.427826087 -0.800395257 -0.520720721 yes kegg kegg NA NA no up up no no no Ras signaling pathway alpha-Linolenic acid metabolism -0.407826087 -0.519762846 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Amino sugar and nucleotide sugar metabolism -0.419130435 0 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Antifolate resistance 0 0 0.484684685 yes kegg kegg NA NA no up up no no no Ras signaling pathway Arginine and proline metabolism -0.486956522 -0.597826087 0 yes kegg kegg NA NA no up up no up no Ras signaling pathway Arginine biosynthesis -0.433913043 -0.768774704 -0.591505792 yes kegg kegg NA NA no up up no no no Ras signaling pathway Basal transcription factors 0 0 0.648133848 yes kegg kegg NA NA no up up no no no Ras signaling pathway Base excision repair 0 0 0.463320463 yes kegg kegg NA NA no up up no no no Ras signaling pathway Biosynthesis of amino acids 0 -0.518774704 -0.703989704 yes kegg kegg NA NA no up up no no no Ras signaling pathway Biosynthesis of cofactors 0 0 -0.405405405 yes kegg kegg NA NA no up up no no no Ras signaling pathway Blautia -0.422608696 0 0 yes acetate-producing kegg Genus NA 1.36E-05 no up up up dn dn Ras signaling pathway Butanoate metabolism 0 0.656126482 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Carbon metabolism 0 0 -0.521235521 yes kegg kegg NA NA no up up no no no Ras signaling pathway Citrate cycle (TCA cycle) 0 0.639328063 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Cysteine and methionine metabolism 0 0.570158103 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway DNA replication 0 0.659090909 0.448391248 yes kegg kegg NA NA no up up no no no Ras signaling pathway Drug metabolism - cytochrome P450 0 0.65513834 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Drug metabolism - other enzymes 0 0.726284585 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway EGFR tyrosine kinase inhibitor resistance 0 0.458498024 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway ErbB signaling pathway 0 0 0.504247104 yes kegg kegg NA NA no up up no no no Ras signaling pathway Ether lipid metabolism 0 0.458498024 0.575032175 yes kegg kegg NA NA no up up no no no Ras signaling pathway Fanconi anemia pathway 0 0 0.496010296 yes kegg kegg NA NA no up up no no no Ras signaling pathway Fatty acid biosynthesis 0 -0.752964427 -0.419305019 yes kegg kegg NA NA no up up no no no Ras signaling pathway Fatty acid degradation 0 -0.544466403 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Fatty acid metabolism 0 -0.497035573 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Folate biosynthesis 0 0.604743083 0.431917632 yes kegg kegg NA NA no up up no no no Ras signaling pathway Fructose and mannose metabolism -0.533913043 0 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Galactose metabolism -0.536521739 -0.416007905 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Glutathione metabolism 0 0.464426877 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Glycerolipid metabolism 0 0 0.457400257 yes kegg kegg NA NA no up up no no up Ras signaling pathway Glycerophospholipid metabolism 0 0 0.622651223 yes kegg kegg NA NA no up up no no up Ras signaling pathway "Glycine, serine and threonine metabolism" 0 0 -0.423680824 yes kegg kegg NA NA no up up no up no Ras signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.590909091 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.706521739 0.48983269 yes kegg kegg NA NA no up up no no no Ras signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.695495495 yes kegg kegg NA NA no up up no no no Ras signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 0.435770751 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 0.495238095 yes kegg kegg NA NA no up up no no no Ras signaling pathway Glyoxylate and dicarboxylate metabolism -0.47826087 -0.774703557 -0.581209781 yes kegg kegg NA NA no up up no no no Ras signaling pathway Histidine metabolism -0.552173913 0 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Homologous recombination 0 0 0.456628057 yes kegg kegg NA NA no up up no no no Ras signaling pathway Inositol phosphate metabolism 0 0 0.520720721 yes kegg kegg NA NA no up up no no no Ras signaling pathway Linoleic acid metabolism 0 0 0.574002574 yes kegg kegg NA NA no up up no no no Ras signaling pathway Lysine degradation 0 0 0.690604891 yes kegg kegg NA NA no up up no no no Ras signaling pathway Mannose type O-glycan biosynthesis 0 0 0.738481338 yes kegg kegg NA NA no up up no no no Ras signaling pathway Metabolism of xenobiotics by cytochrome P450 0 0.656126482 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Mismatch repair 0 0.531620553 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway mRNA surveillance pathway 0 0.599802372 0.716602317 yes kegg kegg NA NA no up up no no no Ras signaling pathway N-Glycan biosynthesis 0.450434783 0.777667984 0.502187902 yes kegg kegg NA NA no up up no no no Ras signaling pathway Nicotinate and nicotinamide metabolism 0 -0.712450593 -0.43037323 yes kegg kegg NA NA no up up no no no Ras signaling pathway Nitrogen metabolism 0 -0.685770751 -0.468983269 yes kegg kegg NA NA no up up no no no Ras signaling pathway Non-homologous end-joining 0 0.447628458 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Nucleotide excision repair 0 0.57312253 0.423938224 yes kegg kegg NA NA no up up no no no Ras signaling pathway One carbon pool by folate 0 0.599802372 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Oscillospira -0.433913043 0 0 yes LPS-producing kegg Genus NA 0.62 no up up no no no Ras signaling pathway Other glycan degradation -0.433913043 0 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Other types of O-glycan biosynthesis 0 0 0.687258687 yes kegg kegg NA NA no up up no no no Ras signaling pathway Oxidative phosphorylation 0 0.52173913 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Pantothenate and CoA biosynthesis 0 -0.654150198 -0.425482625 yes kegg kegg NA NA no up up no no dn Ras signaling pathway Pentose and glucuronate interconversions 0 0.72826087 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Pentose phosphate pathway 0 -0.418972332 -0.601544402 yes kegg kegg NA NA no up up no no no Ras signaling pathway Phenylalanine metabolism 0 0.590909091 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Platinum drug resistance 0 0 0.458172458 yes kegg kegg NA NA no up up no no no Ras signaling pathway Porphyrin and chlorophyll metabolism 0 0 -0.43011583 yes kegg kegg NA NA no up up no no no Ras signaling pathway PPAR signaling pathway 0 -0.671936759 -0.422651223 yes kegg kegg NA NA no up up no no no Ras signaling pathway Propanoate metabolism 0 0.493083004 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Proteasome 0 0.459486166 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Protein export 0 0.694664032 0.534620335 yes kegg kegg NA NA no up up no no no Ras signaling pathway Purine metabolism 0 0 -0.422136422 yes kegg kegg NA NA no up up no no no Ras signaling pathway Pyrimidine metabolism 0 0.684782609 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Pyruvate metabolism 0 0.555335968 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Retinol metabolism 0 0.471343874 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Ribosome 0 0.450592885 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Ribosome biogenesis in eukaryotes 0 0.419960474 0.580694981 yes kegg kegg NA NA no up up no no no Ras signaling pathway RNA degradation 0 0.703557312 0.678764479 yes kegg kegg NA NA no up up no no no Ras signaling pathway RNA polymerase 0 0.496047431 0.523294723 yes kegg kegg NA NA no up up no no no Ras signaling pathway RNA transport 0 0.418972332 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Selenocompound metabolism 0 0 0.465637066 yes kegg kegg NA NA no up up no no no Ras signaling pathway Spliceosome 0 0 0.512226512 yes kegg kegg NA NA no up up no no no Ras signaling pathway Starch and sucrose metabolism -0.447826087 -0.651185771 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Steroid biosynthesis 0 0 0.462805663 yes kegg kegg NA NA no up up no no no Ras signaling pathway Steroid hormone biosynthesis 0 0.448616601 0.418532819 yes kegg kegg NA NA no up up no no no Ras signaling pathway Sulfur metabolism 0 0 -0.508365508 yes kegg kegg NA NA no up up no no no Ras signaling pathway Synthesis and degradation of ketone bodies 0 0.467391304 0.41003861 yes kegg kegg NA NA no up up no no no Ras signaling pathway Terpenoid backbone biosynthesis 0 0 0.587902188 yes kegg kegg NA NA no up up no no no Ras signaling pathway Thiamine metabolism 0 0.453557312 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Tryptophan metabolism 0 0.496047431 0 yes kegg kegg NA NA no up up no up no Ras signaling pathway Tyrosine metabolism 0 0.556324111 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 0.556324111 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway "Valine, leucine and isoleucine degradation" 0 0.617588933 0 yes kegg kegg NA NA no up up no no no Ras signaling pathway Various types of N-glycan biosynthesis 0.486086957 0.746047431 0.466924067 yes kegg kegg NA NA no up up no no no Regulation of actin cytoskeleton ABC transporters 0 -0.657114625 0 kegg kegg NA NA no no no no up up Regulation of actin cytoskeleton Adherens junction 0.70173913 0.685770751 0.628828829 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Antigen processing and presentation 0.546956522 0.494071146 0.522265122 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Apelin signaling pathway 0 0.500988142 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Apoptosis - multiple species -0.728695652 -0.606719368 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Autophagy - animal -0.617391304 -0.693675889 -0.417760618 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Autophagy - other -0.549565217 -0.668972332 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton B cell receptor signaling pathway 0 -0.420948617 -0.40978121 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Basal transcription factors -0.5 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Base excision repair -0.547826087 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton beta-Alanine metabolism 0 0.625494071 0.407207207 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Biosynthesis of unsaturated fatty acids 0 0.623517787 0.464350064 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Butanoate metabolism 0 0.550395257 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton C-type lectin receptor signaling pathway -0.43826087 -0.498023715 -0.561389961 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton cAMP signaling pathway 0 -0.433794466 -0.403346203 yes kegg kegg NA NA no no no no up up Regulation of actin cytoskeleton Carbon metabolism 0.466086957 0.658102767 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Circadian entrainment 0.425217391 0.574110672 0 kegg kegg NA NA no no no no up up Regulation of actin cytoskeleton Circadian rhythm -0.426956522 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Citrate cycle (TCA cycle) 0 0.611660079 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Clostridium 0 0.655091919 0 kegg Genus NA 0.925 no no no no no no Regulation of actin cytoskeleton Complement and coagulation cascades 0 0 0.479021879 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Cysteine and methionine metabolism 0 0.599802372 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Cytokine-cytokine receptor interaction 0 0 0.771685972 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Cytosolic DNA-sensing pathway 0 -0.485177866 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Drug metabolism - cytochrome P450 0.520869565 0.549407115 0.464607465 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Drug metabolism - other enzymes 0.504347826 0.671936759 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton ECM-receptor interaction 0 0.48715415 0 kegg kegg NA NA no no no no up up Regulation of actin cytoskeleton ErbB signaling pathway -0.659130435 -0.720355731 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Fatty acid elongation 0 0.703557312 0.516087516 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Fc epsilon RI signaling pathway 0 -0.424901186 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Focal adhesion 0.743478261 0.802371542 0.715057915 kegg kegg NA NA no no no no up up Regulation of actin cytoskeleton FoxO signaling pathway 0 -0.598814229 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Fructose and mannose metabolism 0 -0.660079051 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Glutamatergic synapse 0 -0.418972332 0 kegg kegg NA NA no no no no up up Regulation of actin cytoskeleton Glutathione metabolism 0 0.425889328 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Glycerolipid metabolism -0.422608696 -0.701581028 0 kegg kegg NA NA no no no no no up Regulation of actin cytoskeleton Glycerophospholipid metabolism -0.826086957 -0.670948617 0 kegg kegg NA NA no no no no no up Regulation of actin cytoskeleton Glycolysis / Gluconeogenesis 0.445217391 0.747035573 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.746047431 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.506956522 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Glycosphingolipid biosynthesis - globo and isoglobo series 0.544347826 0.415019763 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Glycosphingolipid biosynthesis - lacto and neolacto series -0.484347826 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.514782609 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Hedgehog signaling pathway -0.437391304 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Hematopoietic cell lineage 0 0.647233202 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton HIF-1 signaling pathway 0 0.481225296 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Hippo signaling pathway 0.648695652 0.603754941 0.658687259 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Homologous recombination 0 -0.453557312 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Inositol phosphate metabolism 0 -0.664031621 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton JAK-STAT signaling pathway 0 -0.739130435 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Lachnospira 0 0.550037081 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Regulation of actin cytoskeleton Leukocyte transendothelial migration 0.737391304 0.711462451 0.601029601 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Linoleic acid metabolism 0.552173913 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Long-term potentiation 0 0.577075099 0 kegg kegg NA NA no no no no no up Regulation of actin cytoskeleton Longevity regulating pathway -0.577391304 -0.563241107 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Lysine degradation -0.612173913 -0.58201581 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Mannose type O-glycan biosynthesis -0.495652174 -0.543478261 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Metabolism of xenobiotics by cytochrome P450 0.551304348 0.628458498 0.535392535 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Mismatch repair 0 0.458498024 0.491119691 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton mRNA surveillance pathway -0.488695652 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Natural killer cell mediated cytotoxicity 0.493043478 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Neuroactive ligand-receptor interaction 0.534782609 0 0 kegg kegg NA NA no no no up up up Regulation of actin cytoskeleton Neurotrophin signaling pathway 0 -0.501976285 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Neutrophil extracellular trap formation 0.41826087 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton NF-kappa B signaling pathway -0.54 -0.673913043 -0.68030888 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton NOD-like receptor signaling pathway 0 -0.513833992 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Non-homologous end-joining 0 0.707509881 0.414929215 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Notch signaling pathway -0.51826087 -0.554347826 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Oocyte meiosis 0 0.726284585 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Other glycan degradation 0 -0.656126482 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Other types of O-glycan biosynthesis -0.693913043 -0.587944664 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Oxidative phosphorylation 0 0.421936759 0.409009009 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton p53 signaling pathway -0.836521739 -0.696640316 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Paraprevotella 0.547579267 0 0 kegg Genus NA 0.118 no no no no no no Regulation of actin cytoskeleton Pentose and glucuronate interconversions 0.546956522 0.461462451 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Phagosome 0.407826087 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Phenylalanine metabolism 0.539130435 0.578063241 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Phosphatidylinositol signaling system -0.473913043 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Phospholipase D signaling pathway 0 -0.673913043 0 kegg kegg NA NA no no no no up up Regulation of actin cytoskeleton Phototransduction 0.433913043 0.880434783 0.476447876 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Platelet activation 0.724347826 0.696640316 0.629343629 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Platinum drug resistance -0.702608696 -0.584980237 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Primary bile acid biosynthesis 0 0.790513834 0.415186615 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Propanoate metabolism 0 0.627470356 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Proteasome 0 0.635375494 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Protein export 0 0.491106719 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Pyruvate metabolism 0 0.553359684 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Rap1 signaling pathway 0.676521739 0.503952569 0.548519949 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Ras signaling pathway 0 0.51284585 0 yes kegg kegg NA NA no no no no up up Regulation of actin cytoskeleton Retrograde endocannabinoid signaling 0 0.591897233 0.560617761 kegg kegg NA NA no no no no no up Regulation of actin cytoskeleton Ribosome 0 0.444664032 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Ribosome biogenesis in eukaryotes -0.52 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton RIG-I-like receptor signaling pathway -0.408695652 -0.666007905 -0.557528958 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton RNA degradation -0.444347826 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton RNA polymerase -0.508695652 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Selenocompound metabolism -0.767826087 0 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Signaling pathways regulating pluripotency of stem cells -0.496521739 -0.625494071 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton SNARE interactions in vesicular transport 0 -0.621541502 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Spliceosome -0.548695652 -0.644268775 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Steroid biosynthesis 0 0.556324111 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Steroid hormone biosynthesis 0.425217391 0.526679842 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Sulfur metabolism 0 0.433794466 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton T cell receptor signaling pathway 0 -0.611660079 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Taurine and hypotaurine metabolism -0.696521739 -0.803359684 -0.480823681 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton TGF-beta signaling pathway 0 0.656126482 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Thermogenesis 0 0.422924901 0.474646075 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Thiamine metabolism 0 0.46541502 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Tight junction 0.676521739 0.781620553 0.668211068 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton TNF signaling pathway 0 -0.674901186 -0.424195624 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Toll-like receptor signaling pathway 0 -0.492094862 0 yes kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Tryptophan metabolism 0 0.687747036 0 kegg kegg NA NA no no no no up no Regulation of actin cytoskeleton Tyrosine metabolism 0 0.565217391 0.513513514 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton "Valine, leucine and isoleucine degradation" 0 0.437747036 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Vascular smooth muscle contraction 0 0.519762846 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton VEGF signaling pathway 0 -0.48715415 0 kegg kegg NA NA no no no no no no Regulation of actin cytoskeleton Viral protein interaction with cytokine and cytokine receptor 0 0.423913043 0.701673102 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes 2-Oxocarboxylic acid metabolism 0 0 -0.512998713 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes ABC transporters -0.617391304 0 0 kegg kegg NA NA no no no no up up Regulation of lipolysis in adipocytes Adipocytokine signaling pathway 0 0 0.422908623 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Adrenergic signaling in cardiomyocytes 0.735652174 0.557312253 0.567310167 kegg kegg NA NA no no no no no up Regulation of lipolysis in adipocytes alpha-Linolenic acid metabolism -0.48 0 -0.544401544 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Amino sugar and nucleotide sugar metabolism 0 0 -0.44967825 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Aminoacyl-tRNA biosynthesis -0.447826087 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes AMPK signaling pathway 0.434782609 0.460474308 0.533333333 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Antigen processing and presentation 0 -0.429841897 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Arachidonic acid metabolism 0 0.541501976 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Arginine and proline metabolism -0.415652174 0 0 kegg kegg NA NA no no no no up no Regulation of lipolysis in adipocytes Ascorbate and aldarate metabolism 0 0 -0.610553411 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes B cell receptor signaling pathway -0.475652174 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Biosynthesis of amino acids 0 -0.440711462 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Biosynthesis of cofactors 0 0 0.435778636 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Butanoate metabolism -0.415652174 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Calcium signaling pathway 0.554782609 0.664031621 0.533075933 kegg kegg NA NA no no no no up up Regulation of lipolysis in adipocytes cAMP signaling pathway 0.486086957 0 0.551093951 yes kegg kegg NA NA no no no no up up Regulation of lipolysis in adipocytes Carbon metabolism 0 -0.609683794 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Cell adhesion molecules 0 -0.52173913 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Circadian entrainment 0.745217391 0.549407115 0.783783784 kegg kegg NA NA no no no no up up Regulation of lipolysis in adipocytes Citrate cycle (TCA cycle) 0 0 -0.529214929 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Clostridium 0 -0.478838573 0 kegg Genus NA 0.925 no no no no no no Regulation of lipolysis in adipocytes Dopaminergic synapse 0.702608696 0.666007905 0.618018018 kegg kegg NA NA no no no no up no Regulation of lipolysis in adipocytes Drug metabolism - other enzymes 0 0 -0.653539254 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Endocrine resistance 0.785217391 0.799407115 0.815186615 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Endocytosis 0 -0.443675889 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Estrogen signaling pathway 0 0 0.570656371 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Fatty acid degradation -0.449565217 -0.437747036 -0.575289575 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Fatty acid elongation 0 -0.427865613 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Fatty acid metabolism -0.532173913 -0.431818182 -0.455341055 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Fc gamma R-mediated phagocytosis -0.406956522 -0.489130435 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Ferroptosis 0.58173913 0.541501976 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Folate biosynthesis -0.406086957 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Fructose and mannose metabolism 0 0 -0.512483912 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Galactose metabolism -0.52173913 0 -0.666409266 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Gap junction 0.828695652 0.87944664 0.857400257 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Glucagon signaling pathway 0.680869565 0.557312253 0.455341055 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Glutamatergic synapse 0.757391304 0.632411067 0.738738739 kegg kegg NA NA no no no no up up Regulation of lipolysis in adipocytes Glutathione metabolism 0 0.472332016 0.411840412 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Glycerolipid metabolism -0.547826087 0 -0.517889318 kegg kegg NA NA no no no no no up Regulation of lipolysis in adipocytes Glycerophospholipid metabolism 0 0 -0.437580438 kegg kegg NA NA no no no no no up Regulation of lipolysis in adipocytes "Glycine, serine and threonine metabolism" 0 0 0.446589447 kegg kegg NA NA no no no no up no Regulation of lipolysis in adipocytes Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.535135135 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Glycosaminoglycan biosynthesis - keratan sulfate 0.411304348 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Glycosaminoglycan degradation 0 -0.449604743 -0.6998713 kegg kegg NA NA no no no no no up Regulation of lipolysis in adipocytes Glyoxylate and dicarboxylate metabolism -0.497391304 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes GnRH signaling pathway 0.774782609 0.766798419 0.755469755 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Hematopoietic cell lineage 0 -0.504940711 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Hippo signaling pathway - multiple species -0.47826087 0 -0.538996139 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Histidine metabolism -0.503478261 0 -0.532818533 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Inflammatory mediator regulation of TRP channels 0.806956522 0.566205534 0.743114543 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Insulin secretion 0.690434783 0.798418972 0.765765766 yes kegg kegg NA NA no no no no up up Regulation of lipolysis in adipocytes Long-term depression 0.826086957 0.801383399 0.893693694 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Longevity regulating pathway 0.492173913 0 0.457142857 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Longevity regulating pathway - multiple species 0 -0.618577075 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Lysosome 0 -0.43972332 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Melanogenesis 0.733913043 0.592885375 0.771171171 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Mitophagy - animal 0.544347826 0.467391304 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Mucin type O-glycan biosynthesis 0 -0.449604743 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Necroptosis 0.65826087 0.565217391 0.426512227 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Neuroactive ligand-receptor interaction 0 -0.536561265 0 kegg kegg NA NA no no no up up up Regulation of lipolysis in adipocytes NF-kappa B signaling pathway -0.577391304 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes NOD-like receptor signaling pathway -0.473913043 -0.43083004 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Notch signaling pathway 0 0 -0.472586873 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Odoribacter 0 -0.611195534 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Regulation of lipolysis in adipocytes Osteoclast differentiation -0.48 -0.456521739 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Other glycan degradation -0.583478261 0 -0.493693694 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Ovarian steroidogenesis 0.797391304 0.931818182 0.90990991 kegg kegg NA NA no no no no up up Regulation of lipolysis in adipocytes Peroxisome -0.506086957 -0.486166008 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Phagosome 0 -0.432806324 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Porphyrin and chlorophyll metabolism 0 0 0.417245817 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes PPAR signaling pathway 0 -0.473320158 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Prevotella 0 0 0.478384292 acetate-producing kegg Genus NA 0.287 no no no no no no Regulation of lipolysis in adipocytes Primary bile acid biosynthesis 0 -0.459486166 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Proteasome 0 -0.429841897 -0.616988417 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Pyrimidine metabolism -0.434782609 0 -0.415958816 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Renin-angiotensin system 0 -0.437747036 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Retinol metabolism 0 0 -0.524581725 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Serotonergic synapse 0.629565217 0.709486166 0.64041184 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes SNARE interactions in vesicular transport -0.732173913 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Sphingolipid metabolism 0 0 -0.526898327 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Starch and sucrose metabolism -0.433043478 0 -0.640669241 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Steroid hormone biosynthesis 0 0 -0.575032175 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Synaptic vesicle cycle 0 0 -0.5001287 kegg kegg NA NA no no no no up up Regulation of lipolysis in adipocytes Taste transduction 0 0 -0.401801802 kegg kegg NA NA no no no no no up Regulation of lipolysis in adipocytes Th1 and Th2 cell differentiation -0.439130435 -0.535573123 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Th17 cell differentiation -0.443478261 -0.606719368 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Thiamine metabolism -0.420869565 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Thyroid hormone synthesis 0.622608696 0.851778656 0.69034749 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Tryptophan metabolism -0.432173913 -0.416996047 -0.488545689 kegg kegg NA NA no no no no up no Regulation of lipolysis in adipocytes Ubiquinone and other terpenoid-quinone biosynthesis -0.45826087 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Ubiquitin mediated proteolysis 0.517391304 0.464426877 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes "Valine, leucine and isoleucine degradation" -0.427826087 0 0 kegg kegg NA NA no no no no no no Regulation of lipolysis in adipocytes Vascular smooth muscle contraction 0.645217391 0.464426877 0.626254826 kegg kegg NA NA no no no no no no Relaxin signaling pathway 2-Oxocarboxylic acid metabolism -0.609565217 -0.577075099 -0.648906049 kegg kegg NA NA no no no no no no Relaxin signaling pathway Adipocytokine signaling pathway 0.645217391 0.765810277 0.585070785 kegg kegg NA NA no no no no no no Relaxin signaling pathway Adrenergic signaling in cardiomyocytes 0.596521739 0 0.423680824 kegg kegg NA NA no no no no no up Relaxin signaling pathway Aldosterone synthesis and secretion 0.436521739 0 0.511454311 kegg kegg NA NA no no no no up up Relaxin signaling pathway alpha-Linolenic acid metabolism -0.546956522 0 -0.63037323 kegg kegg NA NA no no no no no no Relaxin signaling pathway Amino sugar and nucleotide sugar metabolism -0.54173913 0 -0.47979408 kegg kegg NA NA no no no no no no Relaxin signaling pathway Aminoacyl-tRNA biosynthesis -0.59826087 -0.588932806 -0.469498069 kegg kegg NA NA no no no no no no Relaxin signaling pathway Apelin signaling pathway 0 -0.504940711 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Apoptosis 0 0.640316206 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Arginine and proline metabolism 0 0.46541502 0 kegg kegg NA NA no no no no up no Relaxin signaling pathway Arginine biosynthesis 0 0.427865613 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Ascorbate and aldarate metabolism -0.52173913 0 -0.52972973 kegg kegg NA NA no no no no no no Relaxin signaling pathway Autophagy - animal 0 0.557312253 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Autophagy - other 0.42 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Axon guidance 0.523478261 0 0 kegg kegg NA NA no no no no up up Relaxin signaling pathway B cell receptor signaling pathway 0 0.693675889 0.637837838 kegg kegg NA NA no no no no no no Relaxin signaling pathway Bacteroides 0 -0.496047431 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Relaxin signaling pathway Basal transcription factors 0 -0.502964427 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Base excision repair 0 -0.492094862 -0.543371943 kegg kegg NA NA no no no no no no Relaxin signaling pathway beta-Alanine metabolism -0.808695652 -0.718379447 -0.763191763 kegg kegg NA NA no no no no no no Relaxin signaling pathway Biosynthesis of amino acids -0.533043478 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Biosynthesis of cofactors 0 -0.466403162 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Biosynthesis of unsaturated fatty acids -0.763478261 -0.717391304 -0.743886744 kegg kegg NA NA no no no no no no Relaxin signaling pathway Butanoate metabolism -0.706956522 -0.806324111 -0.685199485 kegg kegg NA NA no no no no no no Relaxin signaling pathway C-type lectin receptor signaling pathway 0.535652174 0.639328063 0.566795367 kegg kegg NA NA no no no no no no Relaxin signaling pathway Calcium signaling pathway 0.533913043 0 0.564478764 kegg kegg NA NA no no no no up up Relaxin signaling pathway cAMP signaling pathway 0.789565217 0.928853755 0.891119691 yes kegg kegg NA NA no no no no up up Relaxin signaling pathway Carbon metabolism -0.651304348 -0.503952569 -0.428314028 kegg kegg NA NA no no no no no no Relaxin signaling pathway Cardiac muscle contraction 0.520869565 0 0 kegg kegg NA NA no no no no no up Relaxin signaling pathway Cell cycle 0 -0.508893281 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Chemokine signaling pathway 0.465217391 0.562252964 0.409009009 kegg kegg NA NA no no no no no no Relaxin signaling pathway Cholinergic synapse 0.446086957 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Circadian entrainment 0 0 0.408494208 kegg kegg NA NA no no no no up up Relaxin signaling pathway Circadian rhythm 0.596521739 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Citrate cycle (TCA cycle) -0.755652174 -0.833003953 -0.707078507 kegg kegg NA NA no no no no no no Relaxin signaling pathway Clostridium 0 -0.536910485 0 kegg Genus NA 0.925 no no no no no no Relaxin signaling pathway Cysteine and methionine metabolism -0.454782609 -0.842885375 -0.497812098 kegg kegg NA NA no no no no no no Relaxin signaling pathway Cytosolic DNA-sensing pathway 0.591304348 0.739130435 0.586872587 kegg kegg NA NA no no no no no no Relaxin signaling pathway DNA replication -0.483478261 -0.777667984 -0.502702703 kegg kegg NA NA no no no no no no Relaxin signaling pathway Dopaminergic synapse 0.647826087 0 0.544916345 kegg kegg NA NA no no no no up no Relaxin signaling pathway Drug metabolism - cytochrome P450 0 -0.733201581 -0.421621622 kegg kegg NA NA no no no no no no Relaxin signaling pathway Drug metabolism - other enzymes -0.706086957 -0.643280632 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway ECM-receptor interaction 0 -0.506916996 0 kegg kegg NA NA no no no no up up Relaxin signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.416996047 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Endocrine resistance 0.437391304 0 0.55958816 kegg kegg NA NA no no no no no no Relaxin signaling pathway ErbB signaling pathway 0.451304348 0.449604743 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Estrogen signaling pathway 0 -0.647233202 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Ether lipid metabolism 0.432173913 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Fanconi anemia pathway 0 -0.499011858 -0.517117117 kegg kegg NA NA no no no no no no Relaxin signaling pathway Fatty acid degradation -0.634782609 0 -0.670527671 kegg kegg NA NA no no no no no no Relaxin signaling pathway Fatty acid elongation -0.82 -0.733201581 -0.726126126 kegg kegg NA NA no no no no no no Relaxin signaling pathway Fatty acid metabolism -0.70173913 0 -0.659459459 kegg kegg NA NA no no no no no no Relaxin signaling pathway Fc epsilon RI signaling pathway 0 0.575098814 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Fc gamma R-mediated phagocytosis -0.552173913 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Ferroptosis 0.422608696 0.624505929 0.428571429 kegg kegg NA NA no no no no no no Relaxin signaling pathway Focal adhesion 0 -0.440711462 0 kegg kegg NA NA no no no no up up Relaxin signaling pathway FoxO signaling pathway 0 0 -0.484427284 kegg kegg NA NA no no no no no no Relaxin signaling pathway Fructose and mannose metabolism -0.414782609 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Galactose metabolism -0.588695652 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Gap junction 0 0.60770751 0.412355212 kegg kegg NA NA no no no no no no Relaxin signaling pathway Glutamatergic synapse 0 0.583003953 0.439124839 kegg kegg NA NA no no no no up up Relaxin signaling pathway Glycolysis / Gluconeogenesis -0.643478261 -0.713438735 -0.566537967 kegg kegg NA NA no no no no no no Relaxin signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.647233202 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.476521739 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0.435652174 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 -0.5 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.529644269 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway GnRH signaling pathway 0.48 0 0.611325611 kegg kegg NA NA no no no no no no Relaxin signaling pathway Hedgehog signaling pathway 0 -0.416996047 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Hematopoietic cell lineage -0.616521739 -0.658102767 -0.531274131 kegg kegg NA NA no no no no no no Relaxin signaling pathway HIF-1 signaling pathway 0 -0.511857708 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Hippo signaling pathway 0 -0.416996047 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Histidine metabolism -0.674782609 0 -0.658172458 kegg kegg NA NA no no no no no no Relaxin signaling pathway Homologous recombination 0 0 -0.496782497 kegg kegg NA NA no no no no no no Relaxin signaling pathway Inositol phosphate metabolism 0 0 -0.415444015 kegg kegg NA NA no no no no no no Relaxin signaling pathway Insulin secretion 0.42173913 0 0.747490347 yes kegg kegg NA NA no no no no up up Relaxin signaling pathway Insulin signaling pathway 0 -0.529644269 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway JAK-STAT signaling pathway 0 0.446640316 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Long-term depression 0.511304348 0.723320158 0.66975547 kegg kegg NA NA no no no no no no Relaxin signaling pathway Long-term potentiation 0 -0.768774704 0 kegg kegg NA NA no no no no no up Relaxin signaling pathway Longevity regulating pathway 0.515652174 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Longevity regulating pathway - multiple species -0.553913043 -0.636363636 -0.669498069 kegg kegg NA NA no no no no no no Relaxin signaling pathway Mannose type O-glycan biosynthesis 0.507826087 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Metabolism of xenobiotics by cytochrome P450 -0.49826087 -0.751976285 -0.455083655 kegg kegg NA NA no no no no no no Relaxin signaling pathway Mismatch repair -0.642608696 -0.849802372 -0.54028314 kegg kegg NA NA no no no no no no Relaxin signaling pathway Mitophagy - animal 0.668695652 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway mRNA surveillance pathway 0.529565217 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway mTOR signaling pathway 0 -0.423913043 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Mucin type O-glycan biosynthesis 0 0 -0.43037323 kegg kegg NA NA no no no no no no Relaxin signaling pathway N-Glycan biosynthesis 0 -0.533596838 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Necroptosis 0.453043478 0.544466403 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Neurotrophin signaling pathway 0.74173913 0.68972332 0.631402831 kegg kegg NA NA no no no no no no Relaxin signaling pathway NF-kappa B signaling pathway 0 0.67687747 0.487516088 kegg kegg NA NA no no no no no no Relaxin signaling pathway Nicotinate and nicotinamide metabolism 0 0.429841897 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Nitrogen metabolism 0 0.492094862 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway NOD-like receptor signaling pathway 0 0.438735178 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Non-homologous end-joining -0.793913043 -0.875494071 -0.661776062 kegg kegg NA NA no no no no no no Relaxin signaling pathway Notch signaling pathway 0 0.515810277 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Nucleotide excision repair -0.535652174 -0.755928854 -0.568854569 kegg kegg NA NA no no no no no no Relaxin signaling pathway One carbon pool by folate -0.528695652 -0.691699605 -0.49009009 kegg kegg NA NA no no no no no no Relaxin signaling pathway Oocyte meiosis 0 -0.821146245 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Ovarian steroidogenesis 0 0 0.504761905 kegg kegg NA NA no no no no up up Relaxin signaling pathway Oxidative phosphorylation 0.47826087 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Paraprevotella -0.447092647 0 0 kegg Genus NA 0.118 no no no no no no Relaxin signaling pathway Pentose and glucuronate interconversions -0.553043478 -0.694664032 -0.488803089 kegg kegg NA NA no no no no no no Relaxin signaling pathway Peroxisome -0.539130435 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Phenylalanine metabolism -0.617391304 -0.688735178 -0.479021879 kegg kegg NA NA no no no no no no Relaxin signaling pathway Phosphatidylinositol signaling system 0 -0.454545455 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Phospholipase D signaling pathway 0 0.781620553 0.546975547 kegg kegg NA NA no no no no up up Relaxin signaling pathway Phototransduction 0 -0.678853755 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Platinum drug resistance 0 0 -0.4002574 kegg kegg NA NA no no no no no no Relaxin signaling pathway PPAR signaling pathway 0 0.420948617 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Primary bile acid biosynthesis -0.769565217 -0.778656126 -0.552895753 kegg kegg NA NA no no no no no no Relaxin signaling pathway Prolactin signaling pathway 0.432173913 0.557312253 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Propanoate metabolism -0.576521739 -0.835968379 -0.487258687 kegg kegg NA NA no no no no no no Relaxin signaling pathway Proteasome 0 -0.751976285 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Protein export 0 -0.530632411 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Protein processing in endoplasmic reticulum 0 -0.448616601 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Pyrimidine metabolism -0.699130435 -0.62944664 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Pyruvate metabolism -0.649565217 -0.78458498 -0.51042471 kegg kegg NA NA no no no no no no Relaxin signaling pathway Ras signaling pathway 0 -0.489130435 0 yes kegg kegg NA NA no no no no up up Relaxin signaling pathway Regulation of actin cytoskeleton 0 -0.57312253 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Regulation of lipolysis in adipocytes 0.422608696 0 0.517117117 kegg kegg NA NA no no no no no no Relaxin signaling pathway Retinol metabolism -0.726956522 -0.670948617 -0.707335907 kegg kegg NA NA no no no no no no Relaxin signaling pathway Ribosome 0.520869565 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Ribosome biogenesis in eukaryotes 0 -0.570158103 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway RIG-I-like receptor signaling pathway 0.453913043 0.65513834 0.638352638 kegg kegg NA NA no no no no no no Relaxin signaling pathway RNA degradation 0.45826087 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway RNA polymerase 0 -0.519762846 -0.444272844 kegg kegg NA NA no no no no no no Relaxin signaling pathway RNA transport 0 -0.446640316 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Selenocompound metabolism 0 0 -0.512741313 kegg kegg NA NA no no no no no no Relaxin signaling pathway Serotonergic synapse 0 0.432806324 0.545431145 kegg kegg NA NA no no no no no no Relaxin signaling pathway Signaling pathways regulating pluripotency of stem cells 0.546956522 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Sphingolipid signaling pathway 0.426956522 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Steroid biosynthesis 0 -0.82312253 -0.68030888 kegg kegg NA NA no no no no no no Relaxin signaling pathway Steroid hormone biosynthesis -0.648695652 -0.716403162 -0.514543115 kegg kegg NA NA no no no no no no Relaxin signaling pathway Sulfur metabolism 0 -0.450592885 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Synthesis and degradation of ketone bodies -0.606086957 -0.802371542 -0.622136422 kegg kegg NA NA no no no no no no Relaxin signaling pathway Taste transduction 0 -0.610671937 0 kegg kegg NA NA no no no no no up Relaxin signaling pathway Taurine and hypotaurine metabolism 0 0.485177866 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Terpenoid backbone biosynthesis 0 -0.670948617 -0.492664093 kegg kegg NA NA no no no no no no Relaxin signaling pathway TGF-beta signaling pathway 0 -0.497035573 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Thermogenesis 0.48173913 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Thiamine metabolism 0 -0.587944664 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway Thyroid hormone synthesis 0 0 0.509137709 kegg kegg NA NA no no no no no no Relaxin signaling pathway TNF signaling pathway 0.820869565 0.788537549 0.681081081 kegg kegg NA NA no no no no no no Relaxin signaling pathway Toll-like receptor signaling pathway 0.526956522 0.66798419 0.581981982 yes kegg kegg NA NA no no no no no no Relaxin signaling pathway Tryptophan metabolism -0.840869565 -0.881422925 -0.711196911 kegg kegg NA NA no no no no up no Relaxin signaling pathway Tyrosine metabolism -0.725217391 -0.78458498 -0.71016731 kegg kegg NA NA no no no no no no Relaxin signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.706956522 -0.77173913 -0.52020592 kegg kegg NA NA no no no no no no Relaxin signaling pathway Ubiquitin mediated proteolysis 0.616521739 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway "Valine, leucine and isoleucine degradation" -0.752173913 -0.773715415 -0.785585586 kegg kegg NA NA no no no no no no Relaxin signaling pathway Various types of N-glycan biosynthesis 0 -0.509881423 -0.45045045 kegg kegg NA NA no no no no no no Relaxin signaling pathway Vascular smooth muscle contraction 0.509565217 0 0 kegg kegg NA NA no no no no no no Relaxin signaling pathway VEGF signaling pathway 0.412173913 0.513833992 0 kegg kegg NA NA no no no no no no Renal cell carcinoma 2-Oxocarboxylic acid metabolism -0.475652174 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma ABC transporters -0.459130435 0 0 kegg kegg NA NA no no no no up up Renal cell carcinoma Adherens junction 0 0 -0.458172458 kegg kegg NA NA no no no no no no Renal cell carcinoma Adrenergic signaling in cardiomyocytes 0.651304348 0 0 kegg kegg NA NA no no no no no up Renal cell carcinoma Alcoholism 0.514782609 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Aldosterone-regulated sodium reabsorption 0.675652174 0.51284585 0 kegg kegg NA NA no no no no no no Renal cell carcinoma alpha-Linolenic acid metabolism -0.544347826 -0.602766798 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Alzheimer disease 0.548695652 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Amino sugar and nucleotide sugar metabolism -0.691304348 -0.610671937 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Aminoacyl-tRNA biosynthesis -0.552173913 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Amyotrophic lateral sclerosis 0.526956522 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Antifolate resistance -0.58173913 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Apelin signaling pathway 0 0.41798419 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Apoptosis 0 0 -0.448133848 kegg kegg NA NA no no no no no no Renal cell carcinoma Apoptosis - multiple species 0 0 0.44967825 kegg kegg NA NA no no no no no no Renal cell carcinoma Arachidonic acid metabolism -0.445217391 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Ascorbate and aldarate metabolism -0.516521739 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Autophagy - animal 0 0 0.431660232 kegg kegg NA NA no no no no no no Renal cell carcinoma Autophagy - other 0.484347826 0 0.488803089 kegg kegg NA NA no no no no no no Renal cell carcinoma Axon guidance 0.832173913 0.674901186 0.534362934 kegg kegg NA NA no no no no up up Renal cell carcinoma beta-Alanine metabolism -0.685217391 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Biosynthesis of amino acids -0.469565217 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Biosynthesis of cofactors -0.426086957 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Biosynthesis of unsaturated fatty acids -0.563478261 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Butanoate metabolism -0.532173913 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Butyricimonas 0.41330708 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Renal cell carcinoma C-type lectin receptor signaling pathway 0.466086957 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Calcium signaling pathway 0.693913043 0 0 kegg kegg NA NA no no no no up up Renal cell carcinoma cAMP signaling pathway 0.674782609 0 0 yes kegg kegg NA NA no no no no up up Renal cell carcinoma Carbohydrate digestion and absorption 0.410434783 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Carbon metabolism -0.50173913 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Cardiac muscle contraction 0.519130435 0 0 kegg kegg NA NA no no no no no up Renal cell carcinoma Chagas disease 0.455652174 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Chemical carcinogenesis - DNA adducts -0.520869565 0 -0.457915058 kegg kegg NA NA no no no no no no Renal cell carcinoma Chemokine signaling pathway 0.42173913 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Circadian rhythm 0.72173913 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Collecting duct acid secretion 0 -0.456521739 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Colorectal cancer 0.648695652 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Coronavirus disease - COVID-19 0.49826087 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Cytosolic DNA-sensing pathway 0 0.435770751 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Dopaminergic synapse 0.445217391 0 0 kegg kegg NA NA no no no no up no Renal cell carcinoma Drug metabolism - other enzymes -0.48173913 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma ECM-receptor interaction 0 0 0.446589447 kegg kegg NA NA no no no no up up Renal cell carcinoma EGFR tyrosine kinase inhibitor resistance 0 0.497035573 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Epstein-Barr virus infection 0 0.414031621 0 kegg kegg NA NA no no no no no no Renal cell carcinoma ErbB signaling pathway 0.566086957 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Fat digestion and absorption -0.577391304 -0.432806324 0 yes kegg kegg NA NA no no no no up up Renal cell carcinoma Fatty acid degradation -0.540869565 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Fatty acid elongation -0.482608696 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Fatty acid metabolism -0.622608696 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Fructose and mannose metabolism -0.686086957 -0.414031621 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Galactose metabolism -0.746086957 -0.498023715 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Gastric acid secretion 0 0 -0.505019305 kegg kegg NA NA no no no no no no Renal cell carcinoma Glucagon signaling pathway 0 0 0.405148005 kegg kegg NA NA no no no no no no Renal cell carcinoma Glycerophospholipid metabolism 0 -0.414031621 0 kegg kegg NA NA no no no no no up Renal cell carcinoma Glycolysis / Gluconeogenesis -0.58173913 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Glycosaminoglycan biosynthesis - keratan sulfate 0.600869565 0.414031621 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Glycosphingolipid biosynthesis - lacto and neolacto series 0.476521739 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Glyoxylate and dicarboxylate metabolism -0.442608696 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma GnRH secretion 0.526086957 0 0 kegg kegg NA NA no no no no up up Renal cell carcinoma Hedgehog signaling pathway 0.445217391 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Hepatitis C 0.457391304 0.438735178 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Herpes simplex virus 1 infection 0 0.41798419 0 kegg kegg NA NA no no no no no no Renal cell carcinoma HIF-1 signaling pathway 0 0.475296443 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Histidine metabolism -0.715652174 -0.57312253 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Human cytomegalovirus infection 0 0.446640316 0 kegg kegg NA NA no no no no no dn Renal cell carcinoma Human immunodeficiency virus 1 infection 0 0.446640316 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Human T-cell leukemia virus 1 infection 0 0.459486166 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Huntington disease 0.513913043 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Inflammatory mediator regulation of TRP channels 0.499130435 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Influenza A 0 0 -0.609266409 kegg kegg NA NA no no no no no no Renal cell carcinoma Insulin resistance 0.406956522 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Insulin signaling pathway 0 0.480237154 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Kaposi sarcoma-associated herpesvirus infection 0.466086957 0 0 kegg kegg NA NA no no no no no dn Renal cell carcinoma Legionellosis 0 0.5 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Leishmaniasis 0 0.420948617 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Long-term potentiation 0.509565217 0 0.457142857 kegg kegg NA NA no no no no no up Renal cell carcinoma Mannose type O-glycan biosynthesis 0.544347826 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Maturity onset diabetes of the young 0 -0.432806324 0 kegg kegg NA NA no no no no up no Renal cell carcinoma Mismatch repair -0.442608696 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma mRNA surveillance pathway 0.575652174 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma mTOR signaling pathway 0 0.515810277 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Mucin type O-glycan biosynthesis 0 0 0.412612613 kegg kegg NA NA no no no no no no Renal cell carcinoma Neurotrophin signaling pathway 0.754782609 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Non-alcoholic fatty liver disease 0.572173913 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Non-homologous end-joining -0.534782609 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Oxidative phosphorylation 0.49826087 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Pancreatic secretion 0.439130435 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma "Parathyroid hormone synthesis, secretion and action" 0.450434783 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Parkinson disease 0.543478261 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Pathways in cancer 0.466956522 0 0.405920206 kegg kegg NA NA no no no no no no Renal cell carcinoma Pathways of neurodegeneration - multiple diseases 0.523478261 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Phenylalanine metabolism -0.525217391 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Phosphatidylinositol signaling system 0.56173913 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma PI3K-Akt signaling pathway 0 0.638339921 0.418532819 yes kegg kegg NA NA no no no no up up Renal cell carcinoma Platinum drug resistance 0 0 0.459459459 kegg kegg NA NA no no no no no no Renal cell carcinoma Primary bile acid biosynthesis -0.509565217 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Prion disease 0.470434783 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Propanoate metabolism -0.42 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Proteasome 0.405217391 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Protein digestion and absorption -0.47826087 0 0 yes kegg kegg NA NA no no no no up up Renal cell carcinoma Protein export 0.414782609 0.429841897 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Proteoglycans in cancer 0 0.550395257 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Pyrimidine metabolism -0.612173913 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Pyruvate metabolism -0.446956522 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Rap1 signaling pathway 0 0 -0.467953668 kegg kegg NA NA no no no no no no Renal cell carcinoma Ras signaling pathway 0.753043478 0 0 yes kegg kegg NA NA no no no no up up Renal cell carcinoma Relaxin signaling pathway 0.540869565 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Retinol metabolism -0.535652174 -0.428853755 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Ribosome 0.497391304 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma RNA degradation 0.65826087 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma RNA transport 0 0.495059289 0.488288288 kegg kegg NA NA no no no no no no Renal cell carcinoma Shigellosis 0.442608696 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Signaling pathways regulating pluripotency of stem cells 0.630434783 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma SNARE interactions in vesicular transport 0 0 -0.453281853 kegg kegg NA NA no no no no no no Renal cell carcinoma Sphingolipid signaling pathway 0.71826087 0.571146245 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Spinocerebellar ataxia 0.632173913 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Spliceosome 0 0 0.411840412 kegg kegg NA NA no no no no no no Renal cell carcinoma Starch and sucrose metabolism -0.539130435 -0.495059289 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Steroid hormone biosynthesis -0.505217391 -0.469367589 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Synaptic vesicle cycle 0 0 -0.415444015 kegg kegg NA NA no no no no up up Renal cell carcinoma Synthesis and degradation of ketone bodies -0.447826087 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma T cell receptor signaling pathway 0 0 0.525353925 kegg kegg NA NA no no no no no no Renal cell carcinoma TGF-beta signaling pathway 0.60173913 0.416007905 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Thermogenesis 0.467826087 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Thyroid hormone signaling pathway 0 0 -0.475160875 kegg kegg NA NA no no no no no no Renal cell carcinoma TNF signaling pathway 0.51826087 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Toxoplasmosis -0.507826087 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Tryptophan metabolism -0.6 0 0 kegg kegg NA NA no no no no up no Renal cell carcinoma Type II diabetes mellitus 0.452173913 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Tyrosine metabolism -0.593043478 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Ubiquinone and other terpenoid-quinone biosynthesis -0.626086957 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma "Valine, leucine and isoleucine degradation" -0.557391304 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Vascular smooth muscle contraction 0.557391304 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma VEGF signaling pathway 0.673913043 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Vibrio cholerae infection 0 0 -0.631402831 kegg kegg NA NA no no no no no no Renal cell carcinoma Viral protein interaction with cytokine and cytokine receptor 0.531304348 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Vitamin digestion and absorption 0 -0.766798419 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Wnt signaling pathway 0.57826087 0 0 kegg kegg NA NA no no no no no no Renal cell carcinoma Yersinia infection 0 0 -0.517889318 kegg kegg NA NA no no no no no no Renin secretion 2-Oxocarboxylic acid metabolism 0 0 -0.428571429 kegg kegg NA NA no no no no no no Renin secretion ABC transporters -0.620869565 0 0 kegg kegg NA NA no no no no up up Renin secretion Adherens junction 0 0.646245059 0 kegg kegg NA NA no no no no no no Renin secretion Adipocytokine signaling pathway 0 -0.453557312 0 kegg kegg NA NA no no no no no no Renin secretion Adrenergic signaling in cardiomyocytes 0.613913043 0.75 0.597940798 kegg kegg NA NA no no no no no up Renin secretion "Alanine, aspartate and glutamate metabolism" -0.646956522 -0.739130435 0 kegg kegg NA NA no no no no no no Renin secretion alpha-Linolenic acid metabolism 0 -0.587944664 -0.596138996 kegg kegg NA NA no no no no no no Renin secretion AMPK signaling pathway 0 0 0.594851995 kegg kegg NA NA no no no no no no Renin secretion Apelin signaling pathway 0 0.653162055 0 kegg kegg NA NA no no no no no no Renin secretion Apoptosis 0 -0.66798419 0 kegg kegg NA NA no no no no no no Renin secretion Arginine and proline metabolism -0.514782609 -0.748023715 0 kegg kegg NA NA no no no no up no Renin secretion Arginine biosynthesis -0.619130435 -0.682806324 0 kegg kegg NA NA no no no no no no Renin secretion Ascorbate and aldarate metabolism 0 0 -0.586357786 kegg kegg NA NA no no no no no no Renin secretion Autophagy - animal -0.49826087 -0.777667984 -0.461776062 kegg kegg NA NA no no no no no no Renin secretion Autophagy - other 0 -0.475296443 0 kegg kegg NA NA no no no no no no Renin secretion B cell receptor signaling pathway -0.684347826 -0.766798419 0 kegg kegg NA NA no no no no no no Renin secretion Biosynthesis of amino acids 0 -0.644268775 0 kegg kegg NA NA no no no no no no Renin secretion Biosynthesis of cofactors 0.416521739 0.491106719 0.484427284 kegg kegg NA NA no no no no no no Renin secretion Butanoate metabolism 0 0.446640316 0 kegg kegg NA NA no no no no no no Renin secretion C-type lectin receptor signaling pathway -0.520869565 -0.800395257 0 kegg kegg NA NA no no no no no no Renin secretion Calcium signaling pathway 0.420869565 0.628458498 0.434234234 kegg kegg NA NA no no no no up up Renin secretion Cardiac muscle contraction 0 0.783596838 0 kegg kegg NA NA no no no no no up Renin secretion Cell adhesion molecules 0 -0.524703557 0 kegg kegg NA NA no no no no no no Renin secretion Cell cycle 0 0.455533597 0 kegg kegg NA NA no no no no no no Renin secretion Cellular senescence 0 -0.504940711 0 kegg kegg NA NA no no no no no no Renin secretion cGMP-PKG signaling pathway 0 -0.60770751 0 kegg kegg NA NA no no no no no no Renin secretion Chemokine signaling pathway 0 -0.529644269 0 kegg kegg NA NA no no no no no no Renin secretion Cholinergic synapse 0 0 -0.423423423 kegg kegg NA NA no no no no no no Renin secretion Circadian entrainment 0.911304348 0.854743083 0.887001287 kegg kegg NA NA no no no no up up Renin secretion Citrate cycle (TCA cycle) 0 0.453557312 0 kegg kegg NA NA no no no no no no Renin secretion Collinsella 0 -0.421497083 0 kegg Genus NA 0.128 no no no no no no Renin secretion Complement and coagulation cascades 0 -0.583003953 0 kegg kegg NA NA no no no no no no Renin secretion Cysteine and methionine metabolism 0 0.5 0 kegg kegg NA NA no no no no no no Renin secretion Cytosolic DNA-sensing pathway 0 -0.414031621 0 kegg kegg NA NA no no no no no no Renin secretion DNA replication 0 0.519762846 0 kegg kegg NA NA no no no no no no Renin secretion Dopaminergic synapse 0.604347826 0.825098814 0.645559846 kegg kegg NA NA no no no no up no Renin secretion Drug metabolism - cytochrome P450 0 0.56916996 0 kegg kegg NA NA no no no no no no Renin secretion Drug metabolism - other enzymes 0 0.565217391 -0.675675676 kegg kegg NA NA no no no no no no Renin secretion EGFR tyrosine kinase inhibitor resistance 0 0.527667984 0 kegg kegg NA NA no no no no no no Renin secretion Endocrine resistance 0.470434783 0 0.688545689 kegg kegg NA NA no no no no no no Renin secretion Endocytosis 0 -0.483201581 0 kegg kegg NA NA no no no no no no Renin secretion ErbB signaling pathway 0 -0.540513834 0 kegg kegg NA NA no no no no no no Renin secretion Estrogen signaling pathway 0.553913043 0.635375494 0.748777349 kegg kegg NA NA no no no no no no Renin secretion Ether lipid metabolism 0 0.511857708 0 kegg kegg NA NA no no no no no no Renin secretion Fatty acid biosynthesis -0.547826087 -0.739130435 0 kegg kegg NA NA no no no no no no Renin secretion Fatty acid degradation -0.5 -0.684782609 -0.448133848 kegg kegg NA NA no no no no no no Renin secretion Fatty acid metabolism -0.48 -0.604743083 0 kegg kegg NA NA no no no no no no Renin secretion Fc epsilon RI signaling pathway 0 -0.733201581 -0.509137709 kegg kegg NA NA no no no no no no Renin secretion Fc gamma R-mediated phagocytosis 0 -0.571146245 0 kegg kegg NA NA no no no no no no Renin secretion Ferroptosis 0.444347826 0 0.419047619 kegg kegg NA NA no no no no no no Renin secretion Focal adhesion 0.426086957 0.570158103 0 kegg kegg NA NA no no no no up up Renin secretion Folate biosynthesis 0 0 -0.400514801 kegg kegg NA NA no no no no no no Renin secretion FoxO signaling pathway 0 -0.586956522 0 kegg kegg NA NA no no no no no no Renin secretion Fructose and mannose metabolism 0 -0.540513834 -0.602831403 kegg kegg NA NA no no no no no no Renin secretion GABAergic synapse 0 -0.533596838 0 kegg kegg NA NA no no no no up up Renin secretion Galactose metabolism 0 -0.66798419 -0.688030888 kegg kegg NA NA no no no no no no Renin secretion Gap junction 0.754782609 0 0.741827542 kegg kegg NA NA no no no no no no Renin secretion Glucagon signaling pathway 0.731304348 0.835968379 0.543371943 kegg kegg NA NA no no no no no no Renin secretion Glutamatergic synapse 0.590434783 0 0.703732304 kegg kegg NA NA no no no no up up Renin secretion Glutathione metabolism 0.442608696 0.66798419 0.497039897 kegg kegg NA NA no no no no no no Renin secretion Glycerolipid metabolism -0.722608696 -0.510869565 -0.595109395 kegg kegg NA NA no no no no no up Renin secretion Glycerophospholipid metabolism -0.407826087 0 -0.418790219 kegg kegg NA NA no no no no no up Renin secretion "Glycine, serine and threonine metabolism" 0.502608696 0.449604743 0.488030888 kegg kegg NA NA no no no no up no Renin secretion Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.565217391 -0.695652174 -0.552638353 kegg kegg NA NA no no no no no no Renin secretion Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.601801802 kegg kegg NA NA no no no no no no Renin secretion Glycosaminoglycan degradation 0 0 -0.75984556 kegg kegg NA NA no no no no no up Renin secretion Glyoxylate and dicarboxylate metabolism -0.70173913 -0.714426877 0 kegg kegg NA NA no no no no no no Renin secretion GnRH signaling pathway 0.629565217 0.530632411 0.74954955 kegg kegg NA NA no no no no no no Renin secretion HIF-1 signaling pathway 0 0.466403162 0 kegg kegg NA NA no no no no no no Renin secretion Hippo signaling pathway 0.5 0.677865613 0 kegg kegg NA NA no no no no no no Renin secretion Hippo signaling pathway - multiple species -0.58173913 -0.633399209 -0.684169884 kegg kegg NA NA no no no no no no Renin secretion Histidine metabolism 0 0 -0.423423423 kegg kegg NA NA no no no no no no Renin secretion IL-17 signaling pathway -0.551304348 -0.557312253 0 kegg kegg NA NA no no no no no no Renin secretion Inflammatory mediator regulation of TRP channels 0.748695652 0.946640316 0.785585586 kegg kegg NA NA no no no no no no Renin secretion Inositol phosphate metabolism -0.44173913 0 0 kegg kegg NA NA no no no no no no Renin secretion Insulin secretion 0.514782609 0.515810277 0.656628057 yes kegg kegg NA NA no no no no up up Renin secretion Insulin signaling pathway 0 0.581027668 0 kegg kegg NA NA no no no no no no Renin secretion JAK-STAT signaling pathway -0.408695652 -0.694664032 0 kegg kegg NA NA no no no no no no Renin secretion Lachnospira 0 0.464047457 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Renin secretion Long-term depression 0.597391304 0 0.741055341 kegg kegg NA NA no no no no no no Renin secretion Longevity regulating pathway 0 0 0.507078507 kegg kegg NA NA no no no no no no Renin secretion Lysosome 0 0 -0.458172458 kegg kegg NA NA no no no no no no Renin secretion MAPK signaling pathway 0 -0.567193676 -0.550579151 kegg kegg NA NA no no no no no no Renin secretion Melanogenesis 0.835652174 0.922924901 0.831660232 kegg kegg NA NA no no no no no no Renin secretion Metabolism of xenobiotics by cytochrome P450 0 0.546442688 0 kegg kegg NA NA no no no no no no Renin secretion Mismatch repair 0 0.434782609 0 kegg kegg NA NA no no no no no no Renin secretion Mitophagy - animal 0.490434783 0.616600791 0.435006435 kegg kegg NA NA no no no no no no Renin secretion mRNA surveillance pathway 0 0.551383399 0 kegg kegg NA NA no no no no no no Renin secretion mTOR signaling pathway 0 0.503952569 0 kegg kegg NA NA no no no no no no Renin secretion Mucin type O-glycan biosynthesis 0 -0.455533597 0 kegg kegg NA NA no no no no no no Renin secretion N-Glycan biosynthesis 0 0.621541502 0 kegg kegg NA NA no no no no no no Renin secretion Natural killer cell mediated cytotoxicity 0 -0.462450593 0 kegg kegg NA NA no no no no no no Renin secretion Necroptosis 0.476521739 0 0.477992278 kegg kegg NA NA no no no no no no Renin secretion Neuroactive ligand-receptor interaction 0 -0.453557312 0 kegg kegg NA NA no no no up up up Renin secretion Neurotrophin signaling pathway 0 -0.682806324 0 kegg kegg NA NA no no no no no no Renin secretion Neutrophil extracellular trap formation 0 -0.460474308 0 kegg kegg NA NA no no no no no no Renin secretion NF-kappa B signaling pathway -0.905217391 -0.786561265 0 kegg kegg NA NA no no no no no no Renin secretion Nicotinate and nicotinamide metabolism -0.569565217 -0.656126482 0 kegg kegg NA NA no no no no no no Renin secretion Nitrogen metabolism -0.480869565 -0.62055336 0 kegg kegg NA NA no no no no no no Renin secretion NOD-like receptor signaling pathway -0.6 -0.84486166 0 kegg kegg NA NA no no no no no no Renin secretion Notch signaling pathway 0 0 -0.54028314 kegg kegg NA NA no no no no no no Renin secretion Nucleotide excision repair 0 0.488142292 0 kegg kegg NA NA no no no no no no Renin secretion Olfactory transduction 0 -0.41798419 0 kegg kegg NA NA no no no no no no Renin secretion One carbon pool by folate 0 0.528656126 0 kegg kegg NA NA no no no no no no Renin secretion Oocyte meiosis 0.412173913 0.4743083 0 kegg kegg NA NA no no no no no no Renin secretion Oscillospira 0 -0.446640316 0 LPS-producing kegg Genus NA 0.62 no no no no no no Renin secretion Osteoclast differentiation -0.687826087 -0.761857708 0 kegg kegg NA NA no no no no no no Renin secretion Other glycan degradation -0.596521739 -0.530632411 -0.591505792 kegg kegg NA NA no no no no no no Renin secretion Ovarian steroidogenesis 0.78 0.556324111 0.792020592 kegg kegg NA NA no no no no up up Renin secretion Oxidative phosphorylation 0 0.821146245 0 kegg kegg NA NA no no no no no no Renin secretion Oxytocin signaling pathway 0.449565217 0.484189723 0 kegg kegg NA NA no no no no no no Renin secretion Pantothenate and CoA biosynthesis -0.506956522 -0.614624506 0 kegg kegg NA NA no no no no no dn Renin secretion Pentose and glucuronate interconversions 0 0.550395257 0 kegg kegg NA NA no no no no no no Renin secretion Pentose phosphate pathway 0 -0.519762846 0 kegg kegg NA NA no no no no no no Renin secretion Peroxisome -0.580869565 -0.67687747 0 kegg kegg NA NA no no no no no no Renin secretion Phagosome 0 -0.475296443 0 kegg kegg NA NA no no no no no no Renin secretion Phenylalanine metabolism 0 0.43972332 0 kegg kegg NA NA no no no no no no Renin secretion Phospholipase D signaling pathway 0 -0.462450593 0 kegg kegg NA NA no no no no up up Renin secretion Phototransduction 0.725217391 0.564229249 0 kegg kegg NA NA no no no no no no Renin secretion Platelet activation 0.56173913 0.632411067 0 kegg kegg NA NA no no no no no no Renin secretion Porphyrin and chlorophyll metabolism 0.467826087 0 0.463063063 kegg kegg NA NA no no no no no no Renin secretion PPAR signaling pathway -0.457391304 -0.824110672 0 kegg kegg NA NA no no no no no no Renin secretion Prolactin signaling pathway 0 -0.673913043 0 kegg kegg NA NA no no no no no no Renin secretion Propanoate metabolism 0 0.460474308 0 kegg kegg NA NA no no no no no no Renin secretion Proteasome 0 0.438735178 -0.501673102 kegg kegg NA NA no no no no no no Renin secretion Protein export 0 0.666996047 0 kegg kegg NA NA no no no no no no Renin secretion Protein processing in endoplasmic reticulum 0.466956522 0.585968379 0 kegg kegg NA NA no no no no no no Renin secretion Purine metabolism 0 0.442687747 0 kegg kegg NA NA no no no no no no Renin secretion Pyrimidine metabolism 0 0.523715415 -0.489317889 kegg kegg NA NA no no no no no no Renin secretion Pyruvate metabolism 0 0.570158103 0 kegg kegg NA NA no no no no no no Renin secretion Rap1 signaling pathway 0 0.482213439 0 kegg kegg NA NA no no no no no no Renin secretion Ras signaling pathway 0 0.589920949 0 yes kegg kegg NA NA no no no no up up Renin secretion Regulation of actin cytoskeleton 0.456521739 0.464426877 0 kegg kegg NA NA no no no no no no Renin secretion Regulation of lipolysis in adipocytes 0.742608696 0.518774704 0.836036036 kegg kegg NA NA no no no no no no Renin secretion Renin-angiotensin system 0 -0.516798419 0 kegg kegg NA NA no no no no no no Renin secretion Retrograde endocannabinoid signaling 0 0.808300395 0 kegg kegg NA NA no no no no no up Renin secretion Ribosome 0 0.694664032 0 kegg kegg NA NA no no no no no no Renin secretion RIG-I-like receptor signaling pathway -0.662608696 -0.802371542 0 kegg kegg NA NA no no no no no no Renin secretion RNA degradation 0 0.608695652 0 kegg kegg NA NA no no no no no no Renin secretion RNA polymerase 0 0.564229249 0 kegg kegg NA NA no no no no no no Renin secretion Serotonergic synapse 0.622608696 0 0.4996139 kegg kegg NA NA no no no no no no Renin secretion SNARE interactions in vesicular transport -0.657391304 -0.675889328 -0.453796654 kegg kegg NA NA no no no no no no Renin secretion Sphingolipid metabolism 0 0 -0.635263835 kegg kegg NA NA no no no no no no Renin secretion Sphingolipid signaling pathway 0 -0.5 0 kegg kegg NA NA no no no no no no Renin secretion Starch and sucrose metabolism -0.46 -0.70256917 -0.655341055 kegg kegg NA NA no no no no no no Renin secretion Steroid biosynthesis 0.506956522 0.485177866 0 kegg kegg NA NA no no no no no no Renin secretion Steroid hormone biosynthesis 0 0 -0.465379665 kegg kegg NA NA no no no no no no Renin secretion Synaptic vesicle cycle 0 -0.448616601 -0.509395109 kegg kegg NA NA no no no no up up Renin secretion T cell receptor signaling pathway 0 -0.718379447 0 kegg kegg NA NA no no no no no no Renin secretion Taste transduction 0 0.451581028 -0.426769627 kegg kegg NA NA no no no no no up Renin secretion TGF-beta signaling pathway 0 0.668972332 0 kegg kegg NA NA no no no no no no Renin secretion Th1 and Th2 cell differentiation -0.414782609 -0.583992095 -0.404375804 kegg kegg NA NA no no no no no no Renin secretion Th17 cell differentiation -0.453043478 -0.634387352 0 kegg kegg NA NA no no no no no no Renin secretion Thermogenesis 0.410434783 0.829051383 0 kegg kegg NA NA no no no no no no Renin secretion Thyroid hormone signaling pathway 0 0.60770751 0 kegg kegg NA NA no no no no no no Renin secretion Thyroid hormone synthesis 0.723478261 0.593873518 0.714028314 kegg kegg NA NA no no no no no no Renin secretion Tight junction 0 0.550395257 0 kegg kegg NA NA no no no no no no Renin secretion TNF signaling pathway 0 -0.747035573 0 kegg kegg NA NA no no no no no no Renin secretion Toll-like receptor signaling pathway -0.514782609 -0.787549407 0 yes kegg kegg NA NA no no no no no no Renin secretion Tyrosine metabolism 0 0.535573123 0 kegg kegg NA NA no no no no no no Renin secretion Ubiquitin mediated proteolysis 0.507826087 0.682806324 0.445302445 kegg kegg NA NA no no no no no no Renin secretion "Valine, leucine and isoleucine degradation" 0 0.450592885 0 kegg kegg NA NA no no no no no no Renin secretion Vascular smooth muscle contraction 0.697391304 0.912055336 0.767567568 kegg kegg NA NA no no no no no no Renin secretion VEGF signaling pathway 0 -0.56027668 -0.422651223 kegg kegg NA NA no no no no no no Renin secretion Wnt signaling pathway 0 0.624505929 0 kegg kegg NA NA no no no no no no Renin-angiotensin system 2-Oxocarboxylic acid metabolism 0 -0.520750988 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Adrenergic signaling in cardiomyocytes 0 -0.641304348 -0.403346203 kegg kegg NA NA no no no no no up Renin-angiotensin system "Alanine, aspartate and glutamate metabolism" 0 0.550395257 0.53024453 kegg kegg NA NA no no no no no no Renin-angiotensin system Aminoacyl-tRNA biosynthesis 0 -0.528656126 -0.475933076 kegg kegg NA NA no no no no no no Renin-angiotensin system AMPK signaling pathway -0.566086957 -0.683794466 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Antifolate resistance 0 -0.618577075 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Antigen processing and presentation 0.406956522 0.457509881 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Apelin signaling pathway 0 -0.513833992 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Apoptosis 0 0.748023715 0.442985843 kegg kegg NA NA no no no no no no Renin-angiotensin system Arginine and proline metabolism 0.425217391 0.679841897 0.504247104 kegg kegg NA NA no no no no up no Renin-angiotensin system Arginine biosynthesis 0.485217391 0.595849802 0.582754183 kegg kegg NA NA no no no no no no Renin-angiotensin system Autophagy - animal 0 0.428853755 0.412870013 kegg kegg NA NA no no no no no no Renin-angiotensin system Axon guidance 0 0 0.466924067 kegg kegg NA NA no no no no up up Renin-angiotensin system Basal transcription factors 0 -0.529644269 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Base excision repair 0 -0.626482213 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Biosynthesis of amino acids 0 0.780632411 0.63037323 kegg kegg NA NA no no no no no no Renin-angiotensin system Biosynthesis of cofactors -0.450434783 -0.726284585 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Butanoate metabolism 0 -0.445652174 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Calcium signaling pathway 0 -0.491106719 0 kegg kegg NA NA no no no no up up Renin-angiotensin system Carbon metabolism 0 0.466403162 0.584555985 kegg kegg NA NA no no no no no no Renin-angiotensin system Cardiac muscle contraction 0 -0.590909091 0 kegg kegg NA NA no no no no no up Renin-angiotensin system Cell adhesion molecules 0 0.711462451 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Cell cycle 0 -0.772727273 -0.487773488 kegg kegg NA NA no no no no no no Renin-angiotensin system Cellular senescence 0 0.675889328 0 kegg kegg NA NA no no no no no no Renin-angiotensin system cGMP-PKG signaling pathway 0.589565217 0.876482213 0.65019305 kegg kegg NA NA no no no no no no Renin-angiotensin system Chemokine signaling pathway 0 0.617588933 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Citrate cycle (TCA cycle) 0 -0.424901186 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Complement and coagulation cascades 0.5 0.813241107 0.505791506 kegg kegg NA NA no no no no no no Renin-angiotensin system DNA replication 0 -0.681818182 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Drug metabolism - cytochrome P450 0 -0.558300395 0 kegg kegg NA NA no no no no no no Renin-angiotensin system EGFR tyrosine kinase inhibitor resistance -0.450434783 -0.463438735 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Endocrine resistance -0.543478261 -0.515810277 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Endocytosis 0 0.757905138 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Ether lipid metabolism 0 -0.613636364 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Fanconi anemia pathway 0 -0.647233202 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Fatty acid biosynthesis 0.509565217 0.634387352 0.606435006 kegg kegg NA NA no no no no no no Renin-angiotensin system Fatty acid degradation 0.420869565 0.475296443 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Fatty acid metabolism 0.422608696 0.598814229 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Glutathione metabolism 0 -0.640316206 0 kegg kegg NA NA no no no no no no Renin-angiotensin system "Glycine, serine and threonine metabolism" -0.503478261 -0.678853755 0 kegg kegg NA NA no no no no up no Renin-angiotensin system Glycosaminoglycan degradation 0.545217391 0.71541502 0 kegg kegg NA NA no no no no no up Renin-angiotensin system Glycosphingolipid biosynthesis - ganglio series 0 -0.432806324 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.634387352 -0.442728443 kegg kegg NA NA no no no no no no Renin-angiotensin system Glyoxylate and dicarboxylate metabolism 0 0.635375494 0.640926641 kegg kegg NA NA no no no no no no Renin-angiotensin system Hedgehog signaling pathway 0 -0.632411067 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Hippo signaling pathway - multiple species 0.471304348 0.539525692 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Homologous recombination 0 -0.468379447 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Linoleic acid metabolism 0 -0.453557312 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Longevity regulating pathway -0.415652174 0 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Lysine degradation -0.432173913 -0.53458498 -0.407464607 kegg kegg NA NA no no no no no no Renin-angiotensin system Lysosome 0.639130435 0.893280632 0.662033462 kegg kegg NA NA no no no no no no Renin-angiotensin system Mannose type O-glycan biosynthesis 0 -0.443675889 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Metabolism of xenobiotics by cytochrome P450 0 -0.421936759 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Mismatch repair 0 -0.528656126 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Mitophagy - animal -0.511304348 -0.640316206 0 kegg kegg NA NA no no no no no no Renin-angiotensin system mRNA surveillance pathway 0 -0.703557312 -0.444787645 kegg kegg NA NA no no no no no no Renin-angiotensin system mTOR signaling pathway -0.437391304 -0.467391304 0 kegg kegg NA NA no no no no no no Renin-angiotensin system N-Glycan biosynthesis 0 -0.641304348 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Neuroactive ligand-receptor interaction 0.717391304 0.875494071 0.731016731 kegg kegg NA NA no no no up up up Renin-angiotensin system Neutrophil extracellular trap formation 0.713043478 0.846837945 0.537966538 kegg kegg NA NA no no no no no no Renin-angiotensin system NF-kappa B signaling pathway 0 0.427865613 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Nicotinate and nicotinamide metabolism 0.66 0.704545455 0.721492921 kegg kegg NA NA no no no no no no Renin-angiotensin system Nitrogen metabolism 0 0.543478261 0.503474903 kegg kegg NA NA no no no no no no Renin-angiotensin system Nucleotide excision repair 0 -0.660079051 0 kegg kegg NA NA no no no no no no Renin-angiotensin system One carbon pool by folate 0 -0.678853755 -0.441698842 kegg kegg NA NA no no no no no no Renin-angiotensin system Osteoclast differentiation 0.659130435 0.851778656 0.606949807 kegg kegg NA NA no no no no no no Renin-angiotensin system Other types of O-glycan biosynthesis 0 -0.592885375 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Oxidative phosphorylation 0 -0.56027668 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Pantothenate and CoA biosynthesis 0.764347826 0.750988142 0.702187902 kegg kegg NA NA no no no no no dn Renin-angiotensin system Pentose and glucuronate interconversions 0 -0.552371542 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Pentose phosphate pathway 0.493043478 0.887351779 0.672586873 kegg kegg NA NA no no no no no no Renin-angiotensin system Peroxisome 0.57826087 0.64229249 0.407207207 kegg kegg NA NA no no no no no no Renin-angiotensin system Phagosome 0 0.815217391 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Porphyrin and chlorophyll metabolism -0.449565217 -0.671936759 0 kegg kegg NA NA no no no no no no Renin-angiotensin system PPAR signaling pathway 0 0.675889328 0.638867439 kegg kegg NA NA no no no no no no Renin-angiotensin system Protein export 0 -0.425889328 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Protein processing in endoplasmic reticulum -0.42173913 -0.754940711 -0.412355212 kegg kegg NA NA no no no no no no Renin-angiotensin system Purine metabolism 0 -0.779644269 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Pyrimidine metabolism 0 -0.611660079 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Pyruvate metabolism 0 -0.541501976 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Ribosome -0.490434783 -0.496047431 -0.453539254 kegg kegg NA NA no no no no no no Renin-angiotensin system Ribosome biogenesis in eukaryotes 0 -0.748023715 -0.435263835 kegg kegg NA NA no no no no no no Renin-angiotensin system RNA degradation 0 -0.666996047 0 kegg kegg NA NA no no no no no no Renin-angiotensin system RNA polymerase 0 -0.809288538 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Selenocompound metabolism 0 -0.441699605 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Sphingolipid signaling pathway 0 0.688735178 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Spliceosome 0 0 -0.438867439 kegg kegg NA NA no no no no no no Renin-angiotensin system Starch and sucrose metabolism 0.553913043 0.622529644 0.444530245 kegg kegg NA NA no no no no no no Renin-angiotensin system Synthesis and degradation of ketone bodies 0 -0.518774704 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Thiamine metabolism 0 -0.460474308 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Tyrosine metabolism 0 -0.51284585 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.463438735 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Ubiquitin mediated proteolysis -0.59826087 -0.749011858 0 kegg kegg NA NA no no no no no no Renin-angiotensin system "Valine, leucine and isoleucine degradation" 0 -0.453557312 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Various types of N-glycan biosynthesis 0 -0.473320158 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Viral protein interaction with cytokine and cytokine receptor 0 0.458498024 0 kegg kegg NA NA no no no no no no Renin-angiotensin system Wnt signaling pathway 0 -0.718379447 0 kegg kegg NA NA no no no no no no Resistin 13-HODE+blood 0 0.602941176 0 DM-assocaited hormones serum_ARA 0.156 0.32 no no no no no no Resistin 14:0/18:2-PC+blood -0.680082559 0 0 DM-assocaited hormones serum_phospholipids 0.156 0.102 no no no no up no Resistin 16:0/20:5-PC+blood -0.589267286 0 0 DM-assocaited hormones serum_phospholipids 0.156 0.628 no no no no no no Resistin 18:0/18:2-PI+blood 0 0 0.440869565 DM-assocaited hormones serum_phospholipids 0.156 0.179 no no no no no no Resistin 18:0/20:3-PC+blood -0.512899897 0 0 DM-assocaited hormones serum_phospholipids 0.156 0.0682 no no no no up no Resistin 18:0/20:4-PI+blood 0 0 0.486086957 DM-assocaited hormones serum_phospholipids 0.156 0.167 no no no no no no Resistin 18:3n6+blood 0 -0.556372549 0 DM-assocaited hormones serum_fattyacid 0.156 0.0463 no no no up no dn Resistin 20:1+blood 0 0.583333333 0 yes DM-assocaited hormones serum_fattyacid 0.156 2.56E-05 no no no dn dn dn Resistin 20:2/18:0-PC+blood -0.533539732 0 0 DM-assocaited hormones serum_phospholipids 0.156 0.0427 no no no no up no Resistin 20:5n3+blood -0.698658411 0 0 DM-assocaited hormones serum_fattyacid 0.156 0.988 no no no no no no Resistin 8-HETE+blood 0 0.49754902 0 DM-assocaited hormones serum_ARA 0.156 0.741 no no no no no no Resistin ACA+blood 0 0 -0.493773945 DM-assocaited hormones serum_bileacids 0.156 0.338 no no no no no no Resistin ACA+stool -0.579587069 0 0 DM-assocaited hormones stool_bileacids 0.156 0.417 no no no no no no Resistin AGE-RAGE signaling pathway in diabetic complications 0 0 0.401403743 DM-assocaited hormones kegg 0.156 NA no no no no no no Resistin Betaine+blood 0.55624355 0 0 DM-assocaited hormones serum_choline 0.156 0.857 no no no no no no Resistin C-peptide -0.52173913 0 0 DM-assocaited hormones DM-assocaited hormones 0.156 0.228 no no no no no no Resistin Creatinine+blood 0 0.539215686 0 DM-assocaited hormones serum_choline 0.156 0.437 no no no no no no Resistin d18:0-24:1-SM+blood 0.498452012 0 0 DM-assocaited hormones serum_phospholipids 0.156 0.0609 no no no no dn dn Resistin d18:1-16:0-SM+blood 0.477812178 0 0.436521739 DM-assocaited hormones serum_phospholipids 0.156 0.14 no no no no no no Resistin d18:1-24:1-SM+blood 0.477812178 0 0 DM-assocaited hormones serum_phospholipids 0.156 0.0123 no no no no dn dn Resistin DCA+stool 0 0 0.577922078 DM-assocaited hormones stool_bileacids 0.156 0.195 no no no no no no Resistin DHA+blood -0.562435501 0 0 DM-assocaited hormones serum_ARA 0.156 0.872 no no no no no no Resistin DPA+blood -0.545923633 0 0 DM-assocaited hormones serum_ARA 0.156 0.519 no no no no no no Resistin EPA+blood -0.69246646 0 0 DM-assocaited hormones serum_ARA 0.156 0.212 no no no no no no Resistin GCA+stool 0 0 -0.461038961 DM-assocaited hormones stool_bileacids 0.156 0.0809 no no no no no no Resistin GCDCA+stool -0.561764706 0 -0.571428571 yes DM-assocaited hormones stool_bileacids 0.156 0.0471 no no no no dn no Resistin GDCA+stool 0 0 -0.652796391 DM-assocaited hormones stool_bileacids 0.156 0.656 no no no no no no Resistin Ghrelin 0 -0.607826087 -0.457703081 yes DM-assocaited hormones DM-assocaited hormones 0.156 0.0108 no no no dn no no Resistin Glucagon 0 0 -0.48907563 DM-assocaited hormones DM-assocaited hormones 0.156 0.0283 no no no no no up Resistin Glycine+blood 0 0 -0.467826087 DM-assocaited hormones serum_aminoacids 0.156 0.00408 no no no dn no up Resistin GPC+blood 0 0 0.502608696 DM-assocaited hormones serum_choline 0.156 0.00427 no no no no up up Resistin IL-1ra 0 0 0.494252874 yes DM-assocaited hormones serum_cytokines 0.156 0.0288 no no no no up no Resistin Insulin -0.611660079 0 0 yes DM-assocaited hormones DM-assocaited hormones 0.156 0.00058 no no no up up no Resistin L-Aspartic acid+blood 0.473684211 0 0 yes DM-assocaited hormones serum_aminoacids 0.156 0.0226 no no no up up no Resistin L-Tryptophan+stool 0 0.664335664 0 DM-assocaited hormones stool_cometabolism 0.156 0.557 no no no no no no Resistin LCA+stool 0 0 0.480519481 DM-assocaited hormones stool_bileacids 0.156 0.314 no no no no no no Resistin Leptin -0.476284585 0 0 DM-assocaited hormones DM-assocaited hormones 0.156 0.706 no no no no no no Resistin n3+blood -0.527347781 0 0 DM-assocaited hormones serum_fattyacid 0.156 0.806 no no no no no no Resistin n6/n3+blood 0.55624355 0 0 DM-assocaited hormones serum_fattyacid 0.156 0.226 no no no no no no Resistin TMAO+blood 0.568627451 0 0 DM-assocaited hormones serum_choline 0.156 0.00706 no no no up up no Resistin UFA%+blood 0 0.5 0 DM-assocaited hormones serum_fattyacid 0.156 0.0236 no no no no dn no Resistin Viral protein interaction with cytokine and cytokine receptor 0 0.43083004 0 DM-assocaited hormones kegg 0.156 NA no no no no no no Retinol metabolism alpha-Linolenic acid metabolism 0.604347826 0 0.626512227 kegg kegg NA NA no no no no no no Retinol metabolism Amino sugar and nucleotide sugar metabolism 0.783478261 0.537549407 0.588674389 kegg kegg NA NA no no no no no no Retinol metabolism Ascorbate and aldarate metabolism 0.491304348 0 0.742084942 kegg kegg NA NA no no no no no no Retinol metabolism beta-Alanine metabolism 0.717391304 0.628458498 0.618532819 kegg kegg NA NA no no no no no no Retinol metabolism Butanoate metabolism 0.604347826 0.749011858 0.634749035 kegg kegg NA NA no no no no no no Retinol metabolism Citrate cycle (TCA cycle) 0.683478261 0.692687747 0.797683398 kegg kegg NA NA no no no no no no Retinol metabolism Cysteine and methionine metabolism 0.700869565 0.608695652 0.558301158 kegg kegg NA NA no no no no no no Retinol metabolism Ether lipid metabolism -0.485217391 0 0.464607465 kegg kegg NA NA no no no no no no Retinol metabolism Fatty acid degradation 0.603478261 0 0.502445302 kegg kegg NA NA no no no no no no Retinol metabolism Fatty acid elongation 0.710434783 0.527667984 0.574517375 kegg kegg NA NA no no no no no no Retinol metabolism Fructose and mannose metabolism 0.488695652 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Galactose metabolism 0.509565217 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Glycerolipid metabolism 0 0 0.420849421 kegg kegg NA NA no no no no no up Retinol metabolism Glycerophospholipid metabolism 0 0 0.47953668 kegg kegg NA NA no no no no no up Retinol metabolism "Glycine, serine and threonine metabolism" 0 0 -0.466409266 kegg kegg NA NA no no no no up no Retinol metabolism Glycolysis / Gluconeogenesis 0.816521739 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.482213439 0.5001287 kegg kegg NA NA no no no no no no Retinol metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.680869565 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Glycosphingolipid biosynthesis - ganglio series 0 0.638339921 0 kegg kegg NA NA no no no no no no Retinol metabolism Glycosphingolipid biosynthesis - lacto and neolacto series -0.717391304 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Histidine metabolism 0.589565217 0.41798419 0.633204633 kegg kegg NA NA no no no no no no Retinol metabolism Inositol phosphate metabolism 0 0 0.544144144 kegg kegg NA NA no no no no no no Retinol metabolism Linoleic acid metabolism 0 0.551383399 0.417760618 kegg kegg NA NA no no no no no no Retinol metabolism Lysine degradation 0 0 0.413384813 kegg kegg NA NA no no no no no no Retinol metabolism Mannose type O-glycan biosynthesis -0.746956522 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Mucin type O-glycan biosynthesis 0.746956522 0 0 kegg kegg NA NA no no no no no no Retinol metabolism N-Glycan biosynthesis 0 0.531620553 0.449420849 kegg kegg NA NA no no no no no no Retinol metabolism One carbon pool by folate 0.586956522 0.83201581 0.638352638 kegg kegg NA NA no no no no no no Retinol metabolism Other glycan degradation 0 0 0.482882883 kegg kegg NA NA no no no no no no Retinol metabolism Other types of O-glycan biosynthesis 0 0 0.502960103 kegg kegg NA NA no no no no no no Retinol metabolism Oxidative phosphorylation -0.433043478 0 0 kegg kegg NA NA no no no no no no Retinol metabolism Pentose and glucuronate interconversions 0.694782609 0.618577075 0.543629344 kegg kegg NA NA no no no no no no Retinol metabolism Phenylalanine metabolism 0.506956522 0.749011858 0.421879022 kegg kegg NA NA no no no no no no Retinol metabolism Primary bile acid biosynthesis 0.790434783 0.579051383 0.427284427 kegg kegg NA NA no no no no no no Retinol metabolism Propanoate metabolism 0.817391304 0.559288538 0.546460746 kegg kegg NA NA no no no no no no Retinol metabolism Pyrimidine metabolism 0.692173913 0.747035573 0 kegg kegg NA NA no no no no no no Retinol metabolism Pyruvate metabolism 0.786086957 0.557312253 0.494723295 kegg kegg NA NA no no no no no no Retinol metabolism Selenocompound metabolism 0 0.576086957 0.71994852 kegg kegg NA NA no no no no no no Retinol metabolism Steroid biosynthesis 0 0.733201581 0.687516088 kegg kegg NA NA no no no no no no Retinol metabolism Steroid hormone biosynthesis 0.752173913 0.764822134 0.658172458 kegg kegg NA NA no no no no no no Retinol metabolism Synthesis and degradation of ketone bodies 0.653913043 0.81027668 0.631145431 kegg kegg NA NA no no no no no no Retinol metabolism Thiamine metabolism 0 0.418972332 0 kegg kegg NA NA no no no no no no Retinol metabolism Tryptophan metabolism 0.751304348 0.695652174 0.688803089 kegg kegg NA NA no no no no up no Retinol metabolism Tyrosine metabolism 0.835652174 0.828063241 0.675675676 kegg kegg NA NA no no no no no no Retinol metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.665217391 0.915019763 0.684169884 kegg kegg NA NA no no no no no no Retinol metabolism "Valine, leucine and isoleucine degradation" 0.722608696 0.816205534 0.796396396 kegg kegg NA NA no no no no no no Retinol metabolism Various types of N-glycan biosynthesis 0 0.498023715 0.536164736 kegg kegg NA NA no no no no no no Retrograde endocannabinoid signaling 2-Oxocarboxylic acid metabolism -0.530434783 0 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling ABC transporters 0 -0.48715415 0 kegg kegg NA NA no no up no up up Retrograde endocannabinoid signaling Adherens junction 0 0.707509881 0.452509653 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Adrenergic signaling in cardiomyocytes 0.496521739 0.733201581 0 kegg kegg NA NA no no up no no up Retrograde endocannabinoid signaling Akkermansia 0 0 -0.406711468 acetate-producing kegg Genus NA 0.23 no no up no no no Retrograde endocannabinoid signaling "Alanine, aspartate and glutamate metabolism" 0 -0.713438735 -0.62985843 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling alpha-Linolenic acid metabolism 0 -0.701581028 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Aminoacyl-tRNA biosynthesis -0.526086957 0 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling AMPK signaling pathway 0 0 -0.493178893 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Apelin signaling pathway 0 0.788537549 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Apoptosis 0 -0.617588933 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Apoptosis - multiple species 0 -0.551383399 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Arginine and proline metabolism 0 -0.697628458 -0.42033462 kegg kegg NA NA no no up no up no Retrograde endocannabinoid signaling Arginine biosynthesis 0 -0.648221344 -0.598198198 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Autophagy - animal 0 -0.758893281 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Autophagy - other 0 -0.47826087 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Axon guidance 0.433913043 0 0 kegg kegg NA NA no no up no up up Retrograde endocannabinoid signaling B cell receptor signaling pathway 0 -0.666007905 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling beta-Alanine metabolism -0.553043478 0 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Biosynthesis of amino acids -0.52 -0.522727273 -0.432689833 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Biosynthesis of cofactors 0 0 -0.457142857 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Butanoate metabolism -0.477391304 0 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling C-type lectin receptor signaling pathway 0 -0.697628458 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Calcium signaling pathway 0 0.682806324 0 kegg kegg NA NA no no up no up up Retrograde endocannabinoid signaling cAMP signaling pathway 0.594782609 0 0 yes kegg kegg NA NA no no up no up up Retrograde endocannabinoid signaling Carbon metabolism -0.539130435 0 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Cardiac muscle contraction 0.83826087 0.897233202 0.802059202 kegg kegg NA NA no no up no no up Retrograde endocannabinoid signaling Cell adhesion molecules -0.52173913 0 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Cell cycle 0 0 0.421364221 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Cellular senescence 0 -0.425889328 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling cGMP-PKG signaling pathway 0 -0.531620553 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Circadian entrainment 0 0.673913043 0 kegg kegg NA NA no no up no up up Retrograde endocannabinoid signaling Circadian rhythm 0.464347826 0 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Citrate cycle (TCA cycle) 0 0.493083004 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Complement and coagulation cascades 0 -0.451581028 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Cysteine and methionine metabolism 0 0.549407115 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling DNA replication 0 0.475296443 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Drug metabolism - cytochrome P450 0 0.570158103 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Drug metabolism - other enzymes 0 0.632411067 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling EGFR tyrosine kinase inhibitor resistance 0 0.677865613 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling ErbB signaling pathway 0 -0.506916996 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Ether lipid metabolism 0.419130435 0 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Fatty acid biosynthesis 0 -0.760869565 -0.491119691 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Fatty acid degradation 0 -0.827075099 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Fatty acid metabolism -0.433913043 -0.727272727 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Fc epsilon RI signaling pathway 0 -0.712450593 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Fc gamma R-mediated phagocytosis 0 -0.541501976 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Focal adhesion 0 0.62055336 0.501158301 kegg kegg NA NA no no up no up up Retrograde endocannabinoid signaling FoxO signaling pathway 0 -0.783596838 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Fructose and mannose metabolism -0.539130435 -0.694664032 -0.41956242 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Galactose metabolism -0.54 -0.736166008 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Glutathione metabolism 0 0.781620553 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Glycerolipid metabolism 0 -0.677865613 0 kegg kegg NA NA no no up no no up Retrograde endocannabinoid signaling Glycerophospholipid metabolism 0 -0.515810277 0 kegg kegg NA NA no no up no no up Retrograde endocannabinoid signaling "Glycine, serine and threonine metabolism" 0 0 -0.480823681 kegg kegg NA NA no no up no up no Retrograde endocannabinoid signaling Glycolysis / Gluconeogenesis 0 0.528656126 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.800395257 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.470785071 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Glycosphingolipid biosynthesis - globo and isoglobo series 0 0 -0.446846847 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Glycosphingolipid biosynthesis - lacto and neolacto series 0 -0.414031621 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Glyoxylate and dicarboxylate metabolism -0.476521739 -0.652173913 -0.580952381 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling HIF-1 signaling pathway 0 0.687747036 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Hippo signaling pathway 0 0.646245059 0.552123552 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Hippo signaling pathway - multiple species 0 -0.699604743 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling IL-17 signaling pathway 0 -0.492094862 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Inositol phosphate metabolism 0 -0.574110672 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling JAK-STAT signaling pathway 0 -0.820158103 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Linoleic acid metabolism 0 0 0.43037323 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Long-term potentiation 0 0.431818182 0.55984556 kegg kegg NA NA no no up no no up Retrograde endocannabinoid signaling Longevity regulating pathway 0 0 -0.5003861 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Mannose type O-glycan biosynthesis 0 0 0.410810811 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling MAPK signaling pathway 0 -0.677865613 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Metabolism of xenobiotics by cytochrome P450 0 0.532608696 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Mitophagy - animal 0 0.70256917 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling mRNA surveillance pathway 0 0.508893281 0.404375804 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling mTOR signaling pathway 0 0.658102767 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Mucin type O-glycan biosynthesis 0 -0.441699605 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling N-Glycan biosynthesis 0 0.520750988 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Neurotrophin signaling pathway 0.423478261 -0.447628458 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling NF-kappa B signaling pathway 0 -0.781620553 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Nicotinate and nicotinamide metabolism 0 -0.686758893 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Nitrogen metabolism 0 -0.513833992 -0.542084942 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling NOD-like receptor signaling pathway 0 -0.825098814 -0.417760618 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Non-homologous end-joining -0.452173913 0 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Oocyte meiosis 0.475652174 0.544466403 0.525096525 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Oscillospira 0 -0.537549407 0 LPS-producing kegg Genus NA 0.62 no no up no no no Retrograde endocannabinoid signaling Osteoclast differentiation 0 -0.719367589 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Other glycan degradation 0 -0.622529644 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Oxidative phosphorylation 0.854782609 0.929841897 0.778120978 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Pantothenate and CoA biosynthesis 0 -0.700592885 -0.424453024 kegg kegg NA NA no no up no no dn Retrograde endocannabinoid signaling Pentose and glucuronate interconversions 0 0.522727273 0.471042471 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Pentose phosphate pathway 0 -0.436758893 -0.468468468 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Peroxisome 0 -0.665019763 -0.464350064 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Phagosome -0.473913043 0 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Phosphatidylinositol signaling system 0 0 0.401029601 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Phospholipase D signaling pathway 0 -0.584980237 0 kegg kegg NA NA no no up no up up Retrograde endocannabinoid signaling Platelet activation 0 0.62055336 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Platinum drug resistance 0 -0.4743083 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Porphyrin and chlorophyll metabolism 0 0 -0.464092664 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling PPAR signaling pathway 0 -0.621541502 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Propanoate metabolism 0 0.538537549 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Proteasome 0 0.504940711 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Protein export 0 0.745059289 0.561389961 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Protein processing in endoplasmic reticulum 0 0.579051383 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Purine metabolism -0.424347826 0 -0.477734878 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Pyrimidine metabolism -0.435652174 0.427865613 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Pyruvate metabolism 0 0.624505929 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Rap1 signaling pathway 0 0.480237154 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Ras signaling pathway 0 0.605731225 0.623938224 yes kegg kegg NA NA no no up no up up Retrograde endocannabinoid signaling Renin-angiotensin system 0 -0.509881423 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Ribosome 0 0.868577075 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling RIG-I-like receptor signaling pathway 0 -0.736166008 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling RNA degradation 0 0.581027668 0.431145431 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling RNA polymerase 0 0.462450593 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling RNA transport 0 0.536561265 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling SNARE interactions in vesicular transport 0 -0.726284585 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Starch and sucrose metabolism 0 -0.768774704 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Steroid biosynthesis 0 0 0.400514801 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Sulfur metabolism -0.46173913 0 -0.501415701 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling T cell receptor signaling pathway 0 -0.595849802 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Taurine and hypotaurine metabolism 0 -0.536561265 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling TGF-beta signaling pathway 0.571304348 0.708498024 0.605920206 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Th1 and Th2 cell differentiation 0 -0.541501976 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Th17 cell differentiation 0 -0.562252964 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Thermogenesis 0.748695652 0.925889328 0.744658945 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Thiamine metabolism 0 0.446640316 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Tight junction 0 0.631422925 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling TNF signaling pathway 0 -0.652173913 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Toll-like receptor signaling pathway 0 -0.695652174 0 yes kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Tyrosine metabolism 0 0.424901186 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Ubiquitin mediated proteolysis 0 0.713438735 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Vascular smooth muscle contraction 0.494782609 0.872529644 0 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling VEGF signaling pathway 0 0 0.425740026 kegg kegg NA NA no no up no no no Retrograde endocannabinoid signaling Wnt signaling pathway 0.453913043 0.579051383 0.624195624 kegg kegg NA NA no no up no no no Rheumatoid arthritis 2-Oxocarboxylic acid metabolism 0.52173913 0 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Adrenergic signaling in cardiomyocytes 0 -0.68083004 0 kegg kegg NA NA no no no no no up Rheumatoid arthritis African trypanosomiasis -0.507826087 0 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis AGE-RAGE signaling pathway in diabetic complications 0 0.51284585 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis "Alanine, aspartate and glutamate metabolism" 0 0.456521739 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Aldosterone synthesis and secretion 0 -0.834980237 0 kegg kegg NA NA no no no no up up Rheumatoid arthritis Alzheimer disease -0.47826087 -0.577075099 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Amoebiasis 0 0.419960474 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Amphetamine addiction -0.466086957 -0.825098814 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis AMPK signaling pathway 0 -0.725296443 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Amyotrophic lateral sclerosis -0.448695652 -0.62944664 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Antifolate resistance 0 -0.538537549 -0.461261261 kegg kegg NA NA no no no no no no Rheumatoid arthritis Antigen processing and presentation 0 0.441699605 0.513256113 kegg kegg NA NA no no no no no no Rheumatoid arthritis Apelin signaling pathway -0.480869565 -0.429841897 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Apoptosis 0 0.700592885 0.444787645 kegg kegg NA NA no no no no no no Rheumatoid arthritis Arginine and proline metabolism 0 0.59486166 0 kegg kegg NA NA no no no no up no Rheumatoid arthritis Arginine biosynthesis 0 0.484189723 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Asthma 0.790434783 0.428853755 0.8 kegg kegg NA NA no no no no no no Rheumatoid arthritis Autoimmune thyroid disease 0.647826087 0.739130435 0.415444015 kegg kegg NA NA no no no no no no Rheumatoid arthritis B cell receptor signaling pathway 0 0.591897233 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Bacterial invasion of epithelial cells 0 0 0.546203346 kegg kegg NA NA no no no no no no Rheumatoid arthritis Basal cell carcinoma -0.446956522 -0.552371542 -0.604633205 kegg kegg NA NA no no no no no no Rheumatoid arthritis Basal transcription factors 0 -0.653162055 -0.417503218 kegg kegg NA NA no no no no no no Rheumatoid arthritis Base excision repair 0 -0.580039526 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis beta-Alanine metabolism 0.515652174 0 0.614671815 kegg kegg NA NA no no no no no no Rheumatoid arthritis Bile secretion 0 -0.4743083 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Biosynthesis of amino acids 0.537391304 0.793478261 0.57992278 kegg kegg NA NA no no no no no no Rheumatoid arthritis Biosynthesis of cofactors 0 -0.687747036 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Biosynthesis of unsaturated fatty acids 0 0 0.432947233 kegg kegg NA NA no no no no no no Rheumatoid arthritis Bladder cancer 0 0.531620553 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis C-type lectin receptor signaling pathway 0 0.588932806 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Calcium signaling pathway 0 -0.564229249 -0.423680824 kegg kegg NA NA no no no no up up Rheumatoid arthritis cAMP signaling pathway -0.51826087 0 -0.402316602 yes kegg kegg NA NA no no no no up up Rheumatoid arthritis Carbon metabolism 0.51826087 0.636363636 0.683655084 kegg kegg NA NA no no no no no no Rheumatoid arthritis Cardiac muscle contraction -0.432173913 -0.566205534 0 kegg kegg NA NA no no no no no up Rheumatoid arthritis Cell adhesion molecules 0.625217391 0.816205534 0.544658945 kegg kegg NA NA no no no no no no Rheumatoid arthritis Cell cycle -0.495652174 -0.768774704 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Cellular senescence 0 0.662055336 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis cGMP-PKG signaling pathway 0 0.812252964 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Chemical carcinogenesis - DNA adducts 0 0.513833992 0.438352638 kegg kegg NA NA no no no no no no Rheumatoid arthritis Chemical carcinogenesis - receptor activation -0.515652174 -0.707509881 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Chemokine signaling pathway 0 0.543478261 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Cholesterol metabolism 0 0.767786561 0 yes kegg kegg NA NA no no no no no up Rheumatoid arthritis Circadian rhythm -0.566086957 -0.77173913 -0.518661519 kegg kegg NA NA no no no no no no Rheumatoid arthritis Cocaine addiction 0 -0.68083004 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Colorectal cancer -0.439130435 0 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Complement and coagulation cascades 0 0.764822134 0.667953668 kegg kegg NA NA no no no no no no Rheumatoid arthritis Coronavirus disease - COVID-19 -0.484347826 -0.421936759 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Cortisol synthesis and secretion 0 -0.75 0 kegg kegg NA NA no no no no no up Rheumatoid arthritis Cushing syndrome -0.44173913 -0.854743083 -0.475160875 kegg kegg NA NA no no no no no up Rheumatoid arthritis DNA replication 0 -0.538537549 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Dopaminergic synapse -0.47826087 -0.585968379 0 kegg kegg NA NA no no no no up no Rheumatoid arthritis Drug metabolism - cytochrome P450 0 0 0.403861004 kegg kegg NA NA no no no no no no Rheumatoid arthritis Endocrine and other factor-regulated calcium reabsorption 0 -0.750988142 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Endocrine resistance 0 -0.649209486 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Endocytosis 0 0.787549407 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Epithelial cell signaling in Helicobacter pylori infection 0 0.717391304 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Epstein-Barr virus infection 0 0.431818182 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Estrogen signaling pathway 0 -0.514822134 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Ether lipid metabolism -0.422608696 -0.636363636 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Fanconi anemia pathway 0 -0.576086957 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Fat digestion and absorption 0 0.65513834 0 yes kegg kegg NA NA no no no no up up Rheumatoid arthritis Fatty acid biosynthesis 0 0.545454545 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Fatty acid degradation 0 0.495059289 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Fatty acid elongation 0 0 0.49034749 kegg kegg NA NA no no no no no no Rheumatoid arthritis Fatty acid metabolism 0 0.585968379 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Fc epsilon RI signaling pathway 0 0.636363636 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Fc gamma R-mediated phagocytosis 0 0.83201581 0.524839125 kegg kegg NA NA no no no no no no Rheumatoid arthritis Focal adhesion 0 0 0.496782497 kegg kegg NA NA no no no no up up Rheumatoid arthritis Folate biosynthesis -0.539130435 0 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Galactose metabolism 0.442608696 0 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Glucagon signaling pathway -0.488695652 -0.866600791 -0.453796654 kegg kegg NA NA no no no no no no Rheumatoid arthritis Glutathione metabolism 0 -0.611660079 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Glycerophospholipid metabolism 0 0 -0.404633205 kegg kegg NA NA no no no no no up Rheumatoid arthritis "Glycine, serine and threonine metabolism" 0 -0.653162055 0 kegg kegg NA NA no no no no up no Rheumatoid arthritis Glycolysis / Gluconeogenesis 0 0 0.62007722 kegg kegg NA NA no no no no no no Rheumatoid arthritis Glycosaminoglycan degradation 0 0.730237154 0 kegg kegg NA NA no no no no no up Rheumatoid arthritis Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 -0.477992278 kegg kegg NA NA no no no no no no Rheumatoid arthritis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.593873518 -0.424195624 kegg kegg NA NA no no no no no no Rheumatoid arthritis Glyoxylate and dicarboxylate metabolism 0 0.541501976 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis GnRH signaling pathway 0 -0.672924901 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Hedgehog signaling pathway 0 -0.592885375 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Hematopoietic cell lineage 0.485217391 0 0.660746461 kegg kegg NA NA no no no no no no Rheumatoid arthritis Hepatitis C -0.45826087 0 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Hippo signaling pathway 0 0 0.403861004 kegg kegg NA NA no no no no no no Rheumatoid arthritis Hippo signaling pathway - multiple species 0 0.444664032 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Histidine metabolism 0 0 0.42033462 kegg kegg NA NA no no no no no no Rheumatoid arthritis Homologous recombination 0 -0.437747036 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Human cytomegalovirus infection 0 0.43083004 0 kegg kegg NA NA no no no no no dn Rheumatoid arthritis Human immunodeficiency virus 1 infection 0 0.415019763 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Human papillomavirus infection 0 0.593873518 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Human T-cell leukemia virus 1 infection 0 0 0.426254826 kegg kegg NA NA no no no no no no Rheumatoid arthritis Huntington disease -0.427826087 -0.596837945 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis IL-17 signaling pathway 0 0.828063241 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Inflammatory bowel disease 0.649565217 0.641304348 0.742084942 kegg kegg NA NA no no no no no no Rheumatoid arthritis Inflammatory mediator regulation of TRP channels 0 -0.682806324 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Influenza A 0.724347826 0.720355731 0.63037323 kegg kegg NA NA no no no no no no Rheumatoid arthritis Insulin resistance -0.499130435 0 -0.552638353 kegg kegg NA NA no no no no no no Rheumatoid arthritis Insulin secretion 0 -0.767786561 0 yes kegg kegg NA NA no no no no up up Rheumatoid arthritis Insulin signaling pathway -0.44 0 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Intestinal immune network for IgA production 0.484347826 0 0.677992278 kegg kegg NA NA no no no no no no Rheumatoid arthritis Leishmaniasis 0 0 0.485456885 kegg kegg NA NA no no no no no no Rheumatoid arthritis Leukocyte transendothelial migration 0 0 0.658687259 kegg kegg NA NA no no no no no no Rheumatoid arthritis Long-term potentiation -0.509565217 0 0 kegg kegg NA NA no no no no no up Rheumatoid arthritis Longevity regulating pathway 0 -0.416007905 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Lysine degradation 0 -0.505928854 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Lysosome 0 0.898221344 0.438610039 kegg kegg NA NA no no no no no no Rheumatoid arthritis Mannose type O-glycan biosynthesis 0 0 -0.404375804 kegg kegg NA NA no no no no no no Rheumatoid arthritis MAPK signaling pathway -0.424347826 0 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Measles -0.489565217 0 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Melanogenesis 0 -0.701581028 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Metabolism of xenobiotics by cytochrome P450 0 0 0.44993565 kegg kegg NA NA no no no no no no Rheumatoid arthritis Mineral absorption 0 -0.442687747 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Mismatch repair 0 -0.456521739 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Mitophagy - animal 0 -0.634387352 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Morphine addiction 0 -0.639328063 0 kegg kegg NA NA no no no no up up Rheumatoid arthritis mRNA surveillance pathway -0.515652174 -0.717391304 -0.573230373 kegg kegg NA NA no no no no no no Rheumatoid arthritis N-Glycan biosynthesis 0 -0.561264822 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Natural killer cell mediated cytotoxicity 0.412173913 0.719367589 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Neuroactive ligand-receptor interaction 0 0.841897233 0.466666667 kegg kegg NA NA no no no up up up Rheumatoid arthritis Neurotrophin signaling pathway 0 0.436758893 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Neutrophil extracellular trap formation 0 0.793478261 0.552638353 kegg kegg NA NA no no no no no no Rheumatoid arthritis Nicotinate and nicotinamide metabolism 0 0.581027668 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Nicotine addiction 0 -0.436758893 0 kegg kegg NA NA no no no no up up Rheumatoid arthritis NOD-like receptor signaling pathway 0 0.62944664 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Non-alcoholic fatty liver disease -0.495652174 -0.566205534 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Nucleotide excision repair 0 -0.608695652 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Olfactory transduction 0 0.712450593 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis One carbon pool by folate 0 -0.604743083 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Oocyte meiosis -0.474782609 0 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Osteoclast differentiation 0 0.772727273 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Other types of O-glycan biosynthesis -0.566956522 -0.621541502 -0.412097812 kegg kegg NA NA no no no no no no Rheumatoid arthritis Ovarian steroidogenesis 0 -0.561264822 0 kegg kegg NA NA no no no no up up Rheumatoid arthritis Oxidative phosphorylation -0.446956522 -0.56027668 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Oxytocin signaling pathway 0 0 0.562419562 kegg kegg NA NA no no no no no no Rheumatoid arthritis p53 signaling pathway 0 -0.43972332 -0.542599743 kegg kegg NA NA no no no no no no Rheumatoid arthritis Pancreatic secretion 0 -0.559288538 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Pantothenate and CoA biosynthesis 0 0.648221344 0 kegg kegg NA NA no no no no no dn Rheumatoid arthritis Paraprevotella 0.446607204 0 0 kegg Genus NA 0.118 no no no no no no Rheumatoid arthritis "Parathyroid hormone synthesis, secretion and action" -0.579130435 -0.570158103 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Parkinson disease -0.493043478 -0.595849802 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Pathogenic Escherichia coli infection 0 0.817193676 0.6002574 kegg kegg NA NA no no no no no no Rheumatoid arthritis Pathways in cancer -0.496521739 0 -0.585842986 kegg kegg NA NA no no no no no no Rheumatoid arthritis Pathways of neurodegeneration - multiple diseases -0.466086957 -0.631422925 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Pentose phosphate pathway 0 0.871541502 0.457142857 kegg kegg NA NA no no no no no no Rheumatoid arthritis Peroxisome 0 0.596837945 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Pertussis 0.603478261 0.880434783 0.605405405 kegg kegg NA NA no no no no no dn Rheumatoid arthritis Phagosome 0.593913043 0.867588933 0.578893179 kegg kegg NA NA no no no no no no Rheumatoid arthritis Phosphatidylinositol signaling system 0 -0.495059289 -0.465637066 kegg kegg NA NA no no no no no no Rheumatoid arthritis PI3K-Akt signaling pathway -0.533043478 0 0 yes kegg kegg NA NA no no no no up up Rheumatoid arthritis Platelet activation 0 0 0.402059202 kegg kegg NA NA no no no no no no Rheumatoid arthritis Porphyrin and chlorophyll metabolism 0 -0.604743083 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis PPAR signaling pathway 0 0.679841897 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Primary bile acid biosynthesis 0 0 0.575289575 kegg kegg NA NA no no no no no no Rheumatoid arthritis Prion disease -0.424347826 -0.517786561 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Prolactin signaling pathway 0 0.481225296 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Prostate cancer 0 0 -0.431660232 kegg kegg NA NA no no no no no no Rheumatoid arthritis Protein digestion and absorption 0.537391304 0.679841897 0 yes kegg kegg NA NA no no no no up up Rheumatoid arthritis Protein export -0.414782609 0 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Protein processing in endoplasmic reticulum 0 -0.66798419 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Proximal tubule bicarbonate reclamation 0 -0.481225296 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Purine metabolism 0 -0.772727273 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Pyrimidine metabolism 0 -0.546442688 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Regulation of lipolysis in adipocytes 0 -0.576086957 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Renin secretion 0 -0.601778656 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Renin-angiotensin system 0 0.887351779 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Retrograde endocannabinoid signaling -0.499130435 -0.516798419 0 kegg kegg NA NA no no no no no up Rheumatoid arthritis Ribosome -0.473913043 -0.43972332 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Ribosome biogenesis in eukaryotes 0 -0.709486166 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis RNA degradation 0 -0.601778656 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis RNA polymerase 0 -0.77173913 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Salmonella infection 0 0.818181818 0.736936937 kegg kegg NA NA no no no no no no Rheumatoid arthritis Selenocompound metabolism 0 -0.467391304 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Shigellosis 0 -0.428853755 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Signaling pathways regulating pluripotency of stem cells -0.483478261 0 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Small cell lung cancer 0 0 -0.614157014 kegg kegg NA NA no no no no no up Rheumatoid arthritis Sphingolipid signaling pathway 0 0.591897233 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Spinocerebellar ataxia 0 -0.577075099 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Spliceosome 0 -0.435770751 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Staphylococcus aureus infection 0.733043478 0.940711462 0.803861004 kegg kegg NA NA no no no up no no Rheumatoid arthritis Starch and sucrose metabolism 0 0.570158103 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Synaptic vesicle cycle 0 0.747035573 0 kegg kegg NA NA no no no no up up Rheumatoid arthritis Synthesis and degradation of ketone bodies 0 -0.466403162 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Systemic lupus erythematosus 0.560869565 0.915019763 0.76010296 kegg kegg NA NA no no no no no no Rheumatoid arthritis T cell receptor signaling pathway -0.477391304 0 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Taste transduction -0.637391304 -0.618577075 0 kegg kegg NA NA no no no no no up Rheumatoid arthritis Taurine and hypotaurine metabolism 0 0 -0.408494208 kegg kegg NA NA no no no no no no Rheumatoid arthritis Th1 and Th2 cell differentiation 0 0.554347826 0.422136422 kegg kegg NA NA no no no no no no Rheumatoid arthritis Th17 cell differentiation 0 0.518774704 0.411325611 kegg kegg NA NA no no no no no no Rheumatoid arthritis Thermogenesis -0.44173913 -0.576086957 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Thyroid hormone synthesis 0 -0.697628458 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Tight junction 0 0 0.503732304 kegg kegg NA NA no no no no no no Rheumatoid arthritis Toll-like receptor signaling pathway 0 0.643280632 0 yes kegg kegg NA NA no no no no no no Rheumatoid arthritis Toxoplasmosis 0.582608696 0.760869565 0.694208494 kegg kegg NA NA no no no no no no Rheumatoid arthritis Transcriptional misregulation in cancer 0 0 -0.466924067 kegg kegg NA NA no no no no no no Rheumatoid arthritis Tuberculosis 0.692173913 0.964426877 0.819047619 kegg kegg NA NA no no no no no dn Rheumatoid arthritis Type I diabetes mellitus 0.647826087 0.73715415 0.409266409 kegg kegg NA NA no no no no no no Rheumatoid arthritis Ubiquitin mediated proteolysis 0 -0.727272727 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Vascular smooth muscle contraction -0.484347826 -0.45256917 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Vasopressin-regulated water reabsorption 0 -0.669960474 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Viral carcinogenesis 0 0.704545455 0 kegg kegg NA NA no no no no no no Rheumatoid arthritis Wnt signaling pathway -0.479130435 -0.664031621 -0.430888031 kegg kegg NA NA no no no no no no Rheumatoid arthritis Yersinia infection 0 0.786561265 0 kegg kegg NA NA no no no no no no Ribosome ABC transporters 0 -0.510869565 0 kegg kegg NA NA no no no no up up Ribosome Akkermansia -0.465558296 0 0 acetate-producing kegg Genus NA 0.23 no no no no no no Ribosome "Alanine, aspartate and glutamate metabolism" -0.546956522 -0.669960474 0 kegg kegg NA NA no no no no no no Ribosome alpha-Linolenic acid metabolism -0.519130435 -0.813241107 0 kegg kegg NA NA no no no no no no Ribosome Amino sugar and nucleotide sugar metabolism -0.549565217 -0.424901186 0 kegg kegg NA NA no no no no no no Ribosome Arginine and proline metabolism -0.44 -0.695652174 0 kegg kegg NA NA no no no no up no Ribosome Arginine biosynthesis -0.619130435 -0.613636364 0 kegg kegg NA NA no no no no no no Ribosome Bacteroides -0.419130435 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Ribosome beta-Alanine metabolism -0.603478261 0 0 kegg kegg NA NA no no no no no no Ribosome Biosynthesis of amino acids -0.780869565 -0.502964427 0 kegg kegg NA NA no no no no no no Ribosome Biosynthesis of unsaturated fatty acids -0.515652174 0 0 kegg kegg NA NA no no no no no no Ribosome Butanoate metabolism 0 0.43972332 0.542084942 kegg kegg NA NA no no no no no no Ribosome Carbon metabolism -0.635652174 0 0 kegg kegg NA NA no no no no no no Ribosome Citrate cycle (TCA cycle) 0 0.473320158 0 kegg kegg NA NA no no no no no no Ribosome Cysteine and methionine metabolism 0 0.651185771 0.544916345 kegg kegg NA NA no no no no no no Ribosome Drug metabolism - cytochrome P450 0 0.543478261 0 kegg kegg NA NA no no no no no no Ribosome Drug metabolism - other enzymes 0 0.589920949 0 kegg kegg NA NA no no no no no no Ribosome EGFR tyrosine kinase inhibitor resistance 0.713913043 0.899209486 0.817245817 kegg kegg NA NA no no no no no no Ribosome Ether lipid metabolism 0.691304348 0 0 kegg kegg NA NA no no no no no no Ribosome Fatty acid biosynthesis -0.503478261 -0.700592885 0 kegg kegg NA NA no no no no no no Ribosome Fatty acid degradation -0.626956522 -0.690711462 0 kegg kegg NA NA no no no no no no Ribosome Fatty acid elongation -0.568695652 0 0 kegg kegg NA NA no no no no no no Ribosome Fatty acid metabolism -0.746956522 -0.640316206 0 kegg kegg NA NA no no no no no no Ribosome Fructose and mannose metabolism -0.559130435 -0.691699605 0 kegg kegg NA NA no no no no no no Ribosome Galactose metabolism -0.70173913 -0.757905138 0 kegg kegg NA NA no no no no no no Ribosome Glutathione metabolism 0 0.730237154 0 kegg kegg NA NA no no no no no no Ribosome Glycerolipid metabolism 0 -0.70256917 0 kegg kegg NA NA no no no no no up Ribosome Glycerophospholipid metabolism 0 -0.529644269 0 kegg kegg NA NA no no no no no up Ribosome Glycolysis / Gluconeogenesis -0.508695652 0.616600791 0 kegg kegg NA NA no no no no no no Ribosome Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.763833992 0 kegg kegg NA NA no no no no no no Ribosome Glycosaminoglycan biosynthesis - keratan sulfate 0.533913043 0 0 kegg kegg NA NA no no no no no no Ribosome Glycosaminoglycan degradation 0 -0.53458498 0 kegg kegg NA NA no no no no no up Ribosome Glycosphingolipid biosynthesis - lacto and neolacto series 0 -0.492094862 0 kegg kegg NA NA no no no no no no Ribosome Glyoxylate and dicarboxylate metabolism -0.633913043 -0.588932806 0 kegg kegg NA NA no no no no no no Ribosome Inositol phosphate metabolism 0 -0.533596838 0 kegg kegg NA NA no no no no no no Ribosome Lysine degradation 0.442608696 0 0 kegg kegg NA NA no no no no no no Ribosome Mannose type O-glycan biosynthesis 0.62 0 0 kegg kegg NA NA no no no no no no Ribosome Metabolism of xenobiotics by cytochrome P450 0 0.48715415 0 kegg kegg NA NA no no no no no no Ribosome N-Glycan biosynthesis 0 0.513833992 0 kegg kegg NA NA no no no no no no Ribosome Nicotinate and nicotinamide metabolism -0.540869565 -0.708498024 0 kegg kegg NA NA no no no no no no Ribosome Nitrogen metabolism -0.572173913 -0.499011858 0 kegg kegg NA NA no no no no no no Ribosome Oscillospira 0 -0.469367589 0 LPS-producing kegg Genus NA 0.62 no no no no no no Ribosome Other glycan degradation 0 -0.628458498 0 kegg kegg NA NA no no no no no no Ribosome Other types of O-glycan biosynthesis 0.467826087 0 0 kegg kegg NA NA no no no no no no Ribosome Oxidative phosphorylation 0.690434783 0.862648221 0 kegg kegg NA NA no no no no no no Ribosome Pantothenate and CoA biosynthesis -0.634782609 -0.746047431 0 kegg kegg NA NA no no no no no dn Ribosome Pentose and glucuronate interconversions 0 0.500988142 0.421106821 kegg kegg NA NA no no no no no no Ribosome Pentose phosphate pathway -0.656521739 -0.48715415 0 kegg kegg NA NA no no no no no no Ribosome Propanoate metabolism 0 0.662055336 0.64993565 kegg kegg NA NA no no no no no no Ribosome Pyrimidine metabolism -0.480869565 0 0 kegg kegg NA NA no no no no no no Ribosome Pyruvate metabolism 0 0.72826087 0.594594595 kegg kegg NA NA no no no no no no Ribosome Retinol metabolism -0.489565217 0 0 kegg kegg NA NA no no no no no no Ribosome Ribosome biogenesis in eukaryotes 0.426956522 0 0 kegg kegg NA NA no no no no no no Ribosome Ruminococcus 0.443478261 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Ribosome Starch and sucrose metabolism -0.648695652 -0.764822134 0 kegg kegg NA NA no no no no no no Ribosome Taurine and hypotaurine metabolism 0 -0.472332016 0 kegg kegg NA NA no no no no no no Ribosome Thiamine metabolism 0 0.587944664 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes 2-Oxocarboxylic acid metabolism 0 0.644268775 0.45997426 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes ABC transporters 0 0 0.416731017 kegg kegg NA NA no no no no up up Ribosome biogenesis in eukaryotes "Alanine, aspartate and glutamate metabolism" 0 -0.506916996 -0.481853282 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Amino sugar and nucleotide sugar metabolism 0 0.446640316 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Aminoacyl-tRNA biosynthesis 0.533913043 0.841897233 0.706821107 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Antifolate resistance 0 0.690711462 0.444272844 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Arachidonic acid metabolism 0 0 -0.566537967 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Arginine and proline metabolism 0 -0.686758893 -0.459202059 kegg kegg NA NA no no no no up no Ribosome biogenesis in eukaryotes Arginine biosynthesis 0 -0.583003953 -0.637323037 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Ascorbate and aldarate metabolism 0 0 0.540540541 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Biosynthesis of amino acids -0.433913043 -0.712450593 -0.73976834 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Biosynthesis of cofactors 0 0.635375494 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Butanoate metabolism 0 0.645256917 0.47953668 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Carbon metabolism 0 0 -0.447361647 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Citrate cycle (TCA cycle) 0 0.617588933 0.663063063 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Coprococcus 0.436521739 0 0 butyrate-producing kegg Genus NA 0.612 no no no no no no Ribosome biogenesis in eukaryotes Cysteine and methionine metabolism 0.499130435 0.613636364 0.656113256 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Drug metabolism - cytochrome P450 0 0.598814229 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes EGFR tyrosine kinase inhibitor resistance 0.66173913 0 0.494723295 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Ether lipid metabolism 0 0.587944664 0.580952381 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Fatty acid biosynthesis 0 -0.526679842 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Folate biosynthesis 0 0.428853755 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Glutathione metabolism 0 0 -0.419305019 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Glycerolipid metabolism 0 0 0.596653797 kegg kegg NA NA no no no no no up Ribosome biogenesis in eukaryotes Glycerophospholipid metabolism 0.45826087 0 0.737451737 kegg kegg NA NA no no no no no up Ribosome biogenesis in eukaryotes "Glycine, serine and threonine metabolism" 0 0.462450593 -0.425997426 kegg kegg NA NA no no no no up no Ribosome biogenesis in eukaryotes Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.493913043 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.523715415 0.477477477 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Glycosaminoglycan degradation -0.766086957 -0.559288538 0 kegg kegg NA NA no no no no no up Ribosome biogenesis in eukaryotes Glycosphingolipid biosynthesis - ganglio series 0 0.668972332 0.420849421 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Glycosphingolipid biosynthesis - globo and isoglobo series -0.508695652 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.693913043 0.600790514 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Glyoxylate and dicarboxylate metabolism 0 -0.610671937 -0.614929215 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Inositol phosphate metabolism 0 0.443675889 0.679279279 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Lysine degradation 0.706086957 0.674901186 0.795881596 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Mannose type O-glycan biosynthesis 0 0.489130435 0.709137709 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Metabolism of xenobiotics by cytochrome P450 0 0.507905138 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes N-Glycan biosynthesis 0.79826087 0.735177866 0.835263835 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Nicotinate and nicotinamide metabolism 0 -0.652173913 -0.58970399 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Nitrogen metabolism -0.573043478 -0.641304348 -0.661776062 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes One carbon pool by folate 0.768695652 0.862648221 0.85997426 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Other glycan degradation 0 0 0.48030888 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Other types of O-glycan biosynthesis 0.713913043 0.692687747 0.851480051 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Pantothenate and CoA biosynthesis 0 -0.520750988 0 kegg kegg NA NA no no no no no dn Ribosome biogenesis in eukaryotes Paraprevotella 0 0.47766557 0 kegg Genus NA 0.118 no no no no no no Ribosome biogenesis in eukaryotes Pentose and glucuronate interconversions 0 0.705533597 0.635778636 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Pentose phosphate pathway -0.688695652 -0.798418972 -0.732303732 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Phenylalanine metabolism 0 0.541501976 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Platinum drug resistance 0.757391304 0.600790514 0.603603604 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Porphyrin and chlorophyll metabolism 0 0 -0.406177606 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Primary bile acid biosynthesis 0.419130435 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Propanoate metabolism 0 0.530632411 0.571171171 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Purine metabolism 0 0.527667984 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Pyrimidine metabolism 0 0.661067194 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Pyruvate metabolism 0.520869565 0.62055336 0.42960103 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Retinol metabolism 0 0.657114625 0.586872587 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Selenocompound metabolism 0.72173913 0.716403162 0.808494208 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Sphingolipid metabolism -0.687826087 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Starch and sucrose metabolism -0.44173913 0 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Steroid biosynthesis 0.557391304 0.601778656 0.542857143 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Steroid hormone biosynthesis 0 0.51284585 0.446332046 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Sulfur metabolism 0 0 -0.562934363 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Synthesis and degradation of ketone bodies 0.606956522 0.807312253 0.716859717 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Taurine and hypotaurine metabolism 0.413913043 0 0.45971686 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Terpenoid backbone biosynthesis 0.693043478 0.644268775 0.753667954 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Tryptophan metabolism 0 0 0.439124839 kegg kegg NA NA no no no no up no Ribosome biogenesis in eukaryotes Tyrosine metabolism 0 0.636363636 0 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Ubiquinone and other terpenoid-quinone biosynthesis 0 0.710474308 0.678764479 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes "Valine, leucine and isoleucine degradation" 0.46173913 0.690711462 0.600772201 kegg kegg NA NA no no no no no no Ribosome biogenesis in eukaryotes Various types of N-glycan biosynthesis 0.700869565 0.666007905 0.799485199 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway 2-Oxocarboxylic acid metabolism -0.515652174 -0.584980237 -0.425740026 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Adherens junction -0.570434783 -0.769762846 -0.537966538 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Adrenergic signaling in cardiomyocytes 0 -0.505928854 0 kegg kegg NA NA no no no no no up RIG-I-like receptor signaling pathway "Alanine, aspartate and glutamate metabolism" 0.555652174 0.809288538 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway alpha-Linolenic acid metabolism 0 0.438735178 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Aminoacyl-tRNA biosynthesis 0 -0.415019763 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Apelin signaling pathway 0 -0.708498024 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Apoptosis 0 0.711462451 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Arachidonic acid metabolism -0.466086957 0 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Arginine and proline metabolism 0.484347826 0.801383399 0.524839125 kegg kegg NA NA no no no no up no RIG-I-like receptor signaling pathway Arginine biosynthesis 0.512173913 0.768774704 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Autophagy - animal 0.782608696 0.943675889 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Autophagy - other 0.625217391 0.58201581 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway beta-Alanine metabolism -0.41826087 -0.527667984 -0.620592021 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Biosynthesis of amino acids 0 0.461462451 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Biosynthesis of cofactors -0.576521739 -0.442687747 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Biosynthesis of unsaturated fatty acids 0 -0.435770751 -0.676705277 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Butanoate metabolism -0.409565217 -0.778656126 -0.628828829 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway cAMP signaling pathway 0 0.549407115 0.562419562 yes kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway Cardiac muscle contraction 0 -0.670948617 0 kegg kegg NA NA no no no no no up RIG-I-like receptor signaling pathway Cell cycle 0 -0.4743083 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Cellular senescence 0 0.468379447 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway cGMP-PKG signaling pathway 0.47826087 0.538537549 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Chemokine signaling pathway 0.433913043 0.563241107 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Citrate cycle (TCA cycle) -0.523478261 -0.763833992 -0.41003861 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Complement and coagulation cascades 0 0.442687747 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Cysteine and methionine metabolism 0 -0.760869565 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway DNA replication 0 -0.742094862 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Drug metabolism - cytochrome P450 0 -0.818181818 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Drug metabolism - other enzymes 0 -0.84486166 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.552371542 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway ErbB signaling pathway 0.446086957 0.578063241 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Ether lipid metabolism 0 0 -0.460746461 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Fatty acid biosynthesis 0.54173913 0.72826087 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Fatty acid degradation 0 0.509881423 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Fatty acid elongation -0.433913043 -0.522727273 -0.652252252 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Focal adhesion -0.607826087 -0.787549407 -0.604890605 kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway FoxO signaling pathway 0.462608696 0.599802372 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Fructose and mannose metabolism 0 0.5 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Galactose metabolism 0 0.429841897 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Gap junction -0.47826087 0 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Glutathione metabolism -0.482608696 -0.589920949 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Glycerolipid metabolism 0 0.497035573 0 kegg kegg NA NA no no no no no up RIG-I-like receptor signaling pathway Glycerophospholipid metabolism 0 0.445652174 0 kegg kegg NA NA no no no no no up RIG-I-like receptor signaling pathway "Glycine, serine and threonine metabolism" -0.549565217 0 0 kegg kegg NA NA no no no no up no RIG-I-like receptor signaling pathway Glycolysis / Gluconeogenesis 0 -0.70256917 -0.482625483 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.508695652 0.833003953 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.608695652 -0.418972332 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Glycosphingolipid biosynthesis - ganglio series -0.407826087 0 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.486166008 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.77173913 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway HIF-1 signaling pathway 0 -0.587944664 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Hippo signaling pathway -0.756521739 -0.805335968 -0.616216216 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Hippo signaling pathway - multiple species 0.452173913 0.67687747 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Histidine metabolism 0 0 -0.424967825 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Lachnospira 0 -0.517420327 0 butyrate-producing kegg Genus NA 0.279 no no no no no no RIG-I-like receptor signaling pathway Linoleic acid metabolism 0 -0.433794466 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Longevity regulating pathway - multiple species 0 0 -0.481338481 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.833003953 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Mismatch repair 0 -0.660079051 -0.510682111 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway mTOR signaling pathway 0 -0.523715415 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway N-Glycan biosynthesis 0 -0.683794466 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway NF-kappa B signaling pathway 0.683478261 0.971343874 0.910939511 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Nicotinate and nicotinamide metabolism 0.512173913 0.720355731 0.402831403 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Nitrogen metabolism 0.491304348 0.738142292 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway NOD-like receptor signaling pathway 0.539130435 0.858695652 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Non-homologous end-joining 0 -0.611660079 -0.537709138 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Notch signaling pathway 0 0.47826087 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Nucleotide excision repair 0 -0.64229249 -0.513256113 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway One carbon pool by folate 0 -0.686758893 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Oocyte meiosis 0 -0.68972332 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Osteoclast differentiation 0.536521739 0.720355731 0.525868726 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Other glycan degradation 0 0.480237154 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Oxidative phosphorylation 0 -0.683794466 -0.403861004 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Pantothenate and CoA biosynthesis 0.440869565 0.603754941 0 kegg kegg NA NA no no no no no dn RIG-I-like receptor signaling pathway Pentose and glucuronate interconversions -0.572173913 -0.755928854 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Peroxisome 0 0.596837945 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Phenylalanine metabolism -0.732173913 -0.749011858 -0.554440154 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Phospholipase D signaling pathway 0 0.729249012 0 kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway Platelet activation -0.653913043 -0.696640316 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Porphyrin and chlorophyll metabolism -0.452173913 0 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway PPAR signaling pathway 0.540869565 0.76284585 0.463577864 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Primary bile acid biosynthesis -0.462608696 -0.562252964 -0.490604891 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Propanoate metabolism 0 -0.727272727 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Proteasome 0 -0.657114625 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Protein export 0 -0.681818182 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Protein processing in endoplasmic reticulum 0 -0.60770751 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Pyrimidine metabolism 0 -0.70256917 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Pyruvate metabolism 0 -0.788537549 -0.47979408 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Rap1 signaling pathway 0 -0.52173913 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Ras signaling pathway 0 -0.7243083 0 yes kegg kegg NA NA no no no no up up RIG-I-like receptor signaling pathway Renin-angiotensin system 0 0.455533597 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Retinol metabolism 0 -0.568181818 -0.465379665 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Ribosome 0 -0.660079051 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Ribosome biogenesis in eukaryotes 0 -0.480237154 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway RNA degradation 0 -0.617588933 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway RNA polymerase 0 -0.583003953 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway RNA transport 0 -0.493083004 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Roseburia -0.448695652 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no RIG-I-like receptor signaling pathway Sarcina 0 0.422326513 0 kegg Genus NA 0.0703 no no no no no no RIG-I-like receptor signaling pathway SNARE interactions in vesicular transport 0 0.683794466 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Sphingolipid signaling pathway 0.425217391 0.471343874 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Starch and sucrose metabolism 0 0.590909091 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Steroid biosynthesis -0.411304348 -0.657114625 -0.658944659 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Steroid hormone biosynthesis -0.449565217 -0.665019763 -0.402574003 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Sulfur metabolism -0.479130435 0 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Synthesis and degradation of ketone bodies 0 -0.572134387 -0.530759331 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Taurine and hypotaurine metabolism 0 0.564229249 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway TGF-beta signaling pathway 0 -0.695652174 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Thiamine metabolism 0 -0.532608696 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Tight junction -0.552173913 -0.65513834 -0.616731017 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Toll-like receptor signaling pathway 0.786086957 0.891304348 0.639124839 yes kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Tryptophan metabolism -0.491304348 -0.661067194 -0.474131274 kegg kegg NA NA no no no no up no RIG-I-like receptor signaling pathway Tyrosine metabolism -0.684347826 -0.81916996 -0.742084942 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.457391304 -0.605731225 -0.466924067 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway "Valine, leucine and isoleucine degradation" -0.44173913 -0.722332016 -0.616988417 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Various types of N-glycan biosynthesis 0 -0.500988142 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Vascular smooth muscle contraction 0 -0.708498024 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway VEGF signaling pathway 0.448695652 0.585968379 0 kegg kegg NA NA no no no no no no RIG-I-like receptor signaling pathway Wnt signaling pathway 0 -0.669960474 0 kegg kegg NA NA no no no no no no RNA degradation 2-Oxocarboxylic acid metabolism -0.412173913 0.718379447 0 kegg kegg NA NA no no no no no no RNA degradation "Alanine, aspartate and glutamate metabolism" 0 -0.881422925 -0.64041184 kegg kegg NA NA no no no no no no RNA degradation alpha-Linolenic acid metabolism -0.666086957 -0.697628458 0 kegg kegg NA NA no no no no no no RNA degradation Amino sugar and nucleotide sugar metabolism -0.64173913 0 0 kegg kegg NA NA no no no no no no RNA degradation Aminoacyl-tRNA biosynthesis 0 0.535573123 0.493436293 kegg kegg NA NA no no no no no no RNA degradation Anaerostipes 0 0.434077367 0 butyrate-producing kegg Genus NA 0.568 no no no no no no RNA degradation Antifolate resistance 0 0 0.406949807 kegg kegg NA NA no no no no no no RNA degradation Arachidonic acid metabolism 0 0 -0.666409266 kegg kegg NA NA no no no no no no RNA degradation Arginine and proline metabolism -0.476521739 -0.791501976 -0.442471042 kegg kegg NA NA no no no no up no RNA degradation Arginine biosynthesis -0.473913043 -0.91798419 -0.745945946 kegg kegg NA NA no no no no no no RNA degradation Ascorbate and aldarate metabolism 0 0.482213439 0.432175032 kegg kegg NA NA no no no no no no RNA degradation beta-Alanine metabolism -0.64173913 0 0 kegg kegg NA NA no no no no no no RNA degradation Biosynthesis of amino acids -0.839130435 -0.835968379 -0.765765766 kegg kegg NA NA no no no no no no RNA degradation Biosynthesis of cofactors 0 0.461462451 -0.517889318 kegg kegg NA NA no no no no no no RNA degradation Butanoate metabolism -0.416521739 0.64229249 0 kegg kegg NA NA no no no no no no RNA degradation Carbon metabolism -0.704347826 0 -0.509137709 kegg kegg NA NA no no no no no no RNA degradation Citrate cycle (TCA cycle) 0 0.626482213 0.477477477 kegg kegg NA NA no no no no no no RNA degradation Collinsella 0 0 -0.406569338 kegg Genus NA 0.128 no no no no no no RNA degradation Cysteine and methionine metabolism 0 0.635375494 0.483140283 kegg kegg NA NA no no no no no no RNA degradation Drug metabolism - cytochrome P450 0 0.675889328 0 kegg kegg NA NA no no no no no no RNA degradation Drug metabolism - other enzymes -0.573913043 0.674901186 0 kegg kegg NA NA no no no no no no RNA degradation EGFR tyrosine kinase inhibitor resistance 0.544347826 0.695652174 0.517374517 kegg kegg NA NA no no no no no no RNA degradation Endocrine resistance 0.406956522 0 0 kegg kegg NA NA no no no no no no RNA degradation Ether lipid metabolism 0.751304348 0.571146245 0.505791506 kegg kegg NA NA no no no no no no RNA degradation Fatty acid biosynthesis 0 -0.887351779 0 kegg kegg NA NA no no no no no no RNA degradation Fatty acid degradation -0.56 -0.678853755 0 kegg kegg NA NA no no no no no no RNA degradation Fatty acid elongation -0.452173913 0 0 kegg kegg NA NA no no no no no no RNA degradation Fatty acid metabolism -0.649565217 -0.722332016 0 kegg kegg NA NA no no no no no no RNA degradation Folate biosynthesis 0 0.779644269 0 kegg kegg NA NA no no no no no no RNA degradation Fructose and mannose metabolism -0.691304348 0 0 kegg kegg NA NA no no no no no no RNA degradation Galactose metabolism -0.677391304 -0.562252964 0 kegg kegg NA NA no no no no no no RNA degradation Glutathione metabolism 0 0.537549407 -0.556756757 kegg kegg NA NA no no no no no no RNA degradation Glycerolipid metabolism 0 0 0.658172458 kegg kegg NA NA no no no no no up RNA degradation Glycerophospholipid metabolism 0 0 0.72998713 kegg kegg NA NA no no no no no up RNA degradation "Glycine, serine and threonine metabolism" 0 0 -0.53951094 kegg kegg NA NA no no no no up no RNA degradation Glycolysis / Gluconeogenesis -0.710434783 0 0 kegg kegg NA NA no no no no no no RNA degradation Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.601778656 0 kegg kegg NA NA no no no no no no RNA degradation Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.651185771 0.563963964 kegg kegg NA NA no no no no no no RNA degradation Glycosaminoglycan biosynthesis - keratan sulfate 0.633913043 0.592885375 0.457142857 kegg kegg NA NA no no no no no no RNA degradation Glycosaminoglycan degradation 0 -0.473320158 0 kegg kegg NA NA no no no no no up RNA degradation Glycosphingolipid biosynthesis - ganglio series 0 0.467391304 0 kegg kegg NA NA no no no no no no RNA degradation Glycosphingolipid biosynthesis - lacto and neolacto series 0.684347826 0 0.401801802 kegg kegg NA NA no no no no no no RNA degradation Glyoxylate and dicarboxylate metabolism -0.48173913 -0.908102767 -0.705019305 kegg kegg NA NA no no no no no no RNA degradation Inositol phosphate metabolism 0 0 0.601801802 kegg kegg NA NA no no no no no no RNA degradation Lysine degradation 0.507826087 0.523715415 0.879021879 kegg kegg NA NA no no no no no no RNA degradation Mannose type O-glycan biosynthesis 0.71826087 0.531620553 0.826769627 kegg kegg NA NA no no no no no no RNA degradation Metabolism of xenobiotics by cytochrome P450 -0.429565217 0.614624506 0 kegg kegg NA NA no no no no no no RNA degradation mRNA surveillance pathway 0.948695652 0.898221344 0.91969112 kegg kegg NA NA no no no no no no RNA degradation N-Glycan biosynthesis 0.493043478 0.900197628 0.731531532 kegg kegg NA NA no no no no no no RNA degradation Nicotinate and nicotinamide metabolism -0.434782609 -0.904150198 -0.565250965 kegg kegg NA NA no no no no no no RNA degradation Nitrogen metabolism -0.543478261 -0.867588933 -0.701930502 kegg kegg NA NA no no no no no no RNA degradation One carbon pool by folate 0 0.622529644 0.675675676 kegg kegg NA NA no no no no no no RNA degradation Other glycan degradation 0 0 0.496010296 kegg kegg NA NA no no no no no no RNA degradation Other types of O-glycan biosynthesis 0.588695652 0 0.799227799 kegg kegg NA NA no no no no no no RNA degradation Oxidative phosphorylation 0.626956522 0.65513834 0 kegg kegg NA NA no no no no no no RNA degradation Pantothenate and CoA biosynthesis 0 -0.836956522 -0.45019305 kegg kegg NA NA no no no no no dn RNA degradation Parabacteroides -0.451304348 0 0 kegg Genus NA 4.19E-05 no no no no up up RNA degradation Paraprevotella 0 0.465347547 0 kegg Genus NA 0.118 no no no no no no RNA degradation Pentose and glucuronate interconversions 0 0.814229249 0.599227799 kegg kegg NA NA no no no no no no RNA degradation Pentose phosphate pathway -0.606956522 -0.798418972 -0.744401544 kegg kegg NA NA no no no no no no RNA degradation Phenylalanine metabolism -0.444347826 0.47826087 0 kegg kegg NA NA no no no no no no RNA degradation Platinum drug resistance 0 0 0.446074646 kegg kegg NA NA no no no no no no RNA degradation Porphyrin and chlorophyll metabolism 0 0 -0.541312741 kegg kegg NA NA no no no no no no RNA degradation Propanoate metabolism 0 0.561264822 0 kegg kegg NA NA no no no no no no RNA degradation Pyrimidine metabolism -0.570434783 0.539525692 0 kegg kegg NA NA no no no no no no RNA degradation Pyruvate metabolism 0 0.68972332 0 kegg kegg NA NA no no no no no no RNA degradation Retinol metabolism -0.546086957 0 0 kegg kegg NA NA no no no no no no RNA degradation Ribosome 0.750434783 0.659090909 0 kegg kegg NA NA no no no no no no RNA degradation Ribosome biogenesis in eukaryotes 0.532173913 0.678853755 0.87001287 kegg kegg NA NA no no no no no no RNA degradation RNA transport 0 0.65513834 0.406949807 kegg kegg NA NA no no no no no no RNA degradation Selenocompound metabolism 0.42 0 0.604890605 kegg kegg NA NA no no no no no no RNA degradation Starch and sucrose metabolism -0.656521739 -0.811264822 0 kegg kegg NA NA no no no no no no RNA degradation Steroid biosynthesis 0.486956522 0 0 kegg kegg NA NA no no no no no no RNA degradation Sulfur metabolism 0 0 -0.65019305 kegg kegg NA NA no no no no no no RNA degradation Synthesis and degradation of ketone bodies 0 0.446640316 0.438867439 kegg kegg NA NA no no no no no no RNA degradation Taurine and hypotaurine metabolism 0 0 0.493693694 kegg kegg NA NA no no no no no no RNA degradation Terpenoid backbone biosynthesis 0.451304348 0 0.651222651 kegg kegg NA NA no no no no no no RNA degradation Thiamine metabolism 0 0.515810277 0 kegg kegg NA NA no no no no no no RNA degradation Tryptophan metabolism -0.411304348 0 0 kegg kegg NA NA no no no no up no RNA degradation Tyrosine metabolism -0.465217391 0.462450593 0 kegg kegg NA NA no no no no no no RNA degradation Ubiquinone and other terpenoid-quinone biosynthesis 0 0.457509881 0.421879022 kegg kegg NA NA no no no no no no RNA degradation "Valine, leucine and isoleucine degradation" 0 0.596837945 0 kegg kegg NA NA no no no no no no RNA degradation Various types of N-glycan biosynthesis 0.469565217 0.79743083 0.706048906 kegg kegg NA NA no no no no no no RNA polymerase 2-Oxocarboxylic acid metabolism 0 0.660079051 0.464350064 kegg kegg NA NA no no no no no no RNA polymerase "Alanine, aspartate and glutamate metabolism" 0 -0.662055336 -0.421879022 kegg kegg NA NA no no no no no no RNA polymerase Aminoacyl-tRNA biosynthesis 0 0.767786561 0.570656371 kegg kegg NA NA no no no no no no RNA polymerase Antifolate resistance 0 0.574110672 0.466409266 kegg kegg NA NA no no no no no no RNA polymerase Arginine and proline metabolism -0.416521739 -0.789525692 -0.559330759 kegg kegg NA NA no no no no up no RNA polymerase Arginine biosynthesis 0 -0.723320158 -0.535392535 kegg kegg NA NA no no no no no no RNA polymerase Ascorbate and aldarate metabolism 0 0 0.596653797 kegg kegg NA NA no no no no no no RNA polymerase Biosynthesis of amino acids -0.48173913 -0.834980237 -0.592020592 kegg kegg NA NA no no no no no no RNA polymerase Biosynthesis of cofactors 0 0.656126482 0 kegg kegg NA NA no no no no no no RNA polymerase Butanoate metabolism 0 0.677865613 0.593307593 kegg kegg NA NA no no no no no no RNA polymerase Citrate cycle (TCA cycle) 0 0.66798419 0.693178893 kegg kegg NA NA no no no no no no RNA polymerase Cysteine and methionine metabolism 0 0.688735178 0.594079794 kegg kegg NA NA no no no no no no RNA polymerase Drug metabolism - cytochrome P450 0 0.666996047 0 kegg kegg NA NA no no no no no no RNA polymerase Drug metabolism - other enzymes 0 0.51284585 0 kegg kegg NA NA no no no no no no RNA polymerase EGFR tyrosine kinase inhibitor resistance 0.571304348 0.553359684 0.568597169 kegg kegg NA NA no no no no no no RNA polymerase Ether lipid metabolism 0 0.640316206 0.736422136 kegg kegg NA NA no no no no no no RNA polymerase Fatty acid biosynthesis 0 -0.706521739 0 kegg kegg NA NA no no no no no no RNA polymerase Fatty acid degradation 0 -0.420948617 0 kegg kegg NA NA no no no no no no RNA polymerase Fatty acid metabolism 0 -0.491106719 0 kegg kegg NA NA no no no no no no RNA polymerase Folate biosynthesis 0 0.493083004 0 kegg kegg NA NA no no no no no no RNA polymerase Glutathione metabolism 0 0.493083004 0 kegg kegg NA NA no no no no no no RNA polymerase Glycerolipid metabolism 0 0 0.434234234 kegg kegg NA NA no no no no no up RNA polymerase Glycerophospholipid metabolism 0 0 0.572972973 kegg kegg NA NA no no no no no up RNA polymerase "Glycine, serine and threonine metabolism" 0 0.493083004 0 kegg kegg NA NA no no no no up no RNA polymerase Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.553913043 -0.537549407 0 kegg kegg NA NA no no no no no no RNA polymerase Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.493083004 0.492664093 kegg kegg NA NA no no no no no no RNA polymerase Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.406177606 kegg kegg NA NA no no no no no no RNA polymerase Glycosaminoglycan degradation -0.64173913 -0.59486166 0 kegg kegg NA NA no no no no no up RNA polymerase Glycosphingolipid biosynthesis - ganglio series 0 0.595849802 0 kegg kegg NA NA no no no no no no RNA polymerase Glycosphingolipid biosynthesis - globo and isoglobo series -0.406956522 0 0 kegg kegg NA NA no no no no no no RNA polymerase Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.586956522 0.553359684 0 kegg kegg NA NA no no no no no no RNA polymerase Glyoxylate and dicarboxylate metabolism 0 -0.746047431 -0.456885457 kegg kegg NA NA no no no no no no RNA polymerase Inositol phosphate metabolism 0 0 0.534105534 kegg kegg NA NA no no no no no no RNA polymerase Linoleic acid metabolism 0 0 0.443758044 kegg kegg NA NA no no no no no no RNA polymerase Lysine degradation 0.596521739 0.60770751 0.607979408 kegg kegg NA NA no no no no no no RNA polymerase Mannose type O-glycan biosynthesis 0 0.469367589 0.568854569 kegg kegg NA NA no no no no no no RNA polymerase Metabolism of xenobiotics by cytochrome P450 0 0.57312253 0 kegg kegg NA NA no no no no no no RNA polymerase mRNA surveillance pathway 0.563478261 0.77173913 0.616731017 kegg kegg NA NA no no no no no no RNA polymerase N-Glycan biosynthesis 0.759130435 0.81027668 0.655083655 kegg kegg NA NA no no no no no no RNA polymerase Nicotinate and nicotinamide metabolism 0 -0.800395257 -0.503217503 kegg kegg NA NA no no no no no no RNA polymerase Nitrogen metabolism -0.527826087 -0.738142292 -0.639382239 kegg kegg NA NA no no no no no no RNA polymerase One carbon pool by folate 0.559130435 0.816205534 0.745431145 kegg kegg NA NA no no no no no no RNA polymerase Other types of O-glycan biosynthesis 0.682608696 0.619565217 0.622136422 kegg kegg NA NA no no no no no no RNA polymerase Oxidative phosphorylation 0 0.528656126 0 kegg kegg NA NA no no no no no no RNA polymerase Pantothenate and CoA biosynthesis 0 -0.672924901 0 kegg kegg NA NA no no no no no dn RNA polymerase Pentose and glucuronate interconversions 0 0.792490119 0.556756757 kegg kegg NA NA no no no no no no RNA polymerase Pentose phosphate pathway -0.750434783 -0.880434783 -0.53951094 kegg kegg NA NA no no no no no no RNA polymerase Phenylalanine metabolism 0 0.541501976 0 kegg kegg NA NA no no no no no no RNA polymerase Platinum drug resistance 0.69826087 0.419960474 0.438867439 kegg kegg NA NA no no no no no no RNA polymerase Porphyrin and chlorophyll metabolism 0 0.443675889 0 kegg kegg NA NA no no no no no no RNA polymerase Propanoate metabolism 0 0.60770751 0.584298584 kegg kegg NA NA no no no no no no RNA polymerase Purine metabolism 0 0.564229249 0 kegg kegg NA NA no no no no no no RNA polymerase Pyrimidine metabolism 0 0.641304348 0 kegg kegg NA NA no no no no no no RNA polymerase Pyruvate metabolism 0 0.725296443 0.527155727 kegg kegg NA NA no no no no no no RNA polymerase Retinol metabolism 0 0.56027668 0.627284427 kegg kegg NA NA no no no no no no RNA polymerase Ribosome 0.529565217 0.52173913 0.469240669 kegg kegg NA NA no no no no no no RNA polymerase Ribosome biogenesis in eukaryotes 0.882608696 0.950592885 0.769369369 kegg kegg NA NA no no no no no no RNA polymerase RNA degradation 0.572173913 0.82312253 0.658172458 kegg kegg NA NA no no no no no no RNA polymerase RNA transport 0.513913043 0.514822134 0.405148005 kegg kegg NA NA no no no no no no RNA polymerase Selenocompound metabolism 0.68 0.537549407 0.641441441 kegg kegg NA NA no no no no no no RNA polymerase Sphingolipid metabolism -0.685217391 0 0 kegg kegg NA NA no no no no no no RNA polymerase Starch and sucrose metabolism -0.533913043 -0.613636364 0 kegg kegg NA NA no no no no no no RNA polymerase Steroid biosynthesis 0.653043478 0.580039526 0.66975547 kegg kegg NA NA no no no no no no RNA polymerase Steroid hormone biosynthesis 0 0.489130435 0.466666667 kegg kegg NA NA no no no no no no RNA polymerase Sulfur metabolism 0 0 -0.408494208 kegg kegg NA NA no no no no no no RNA polymerase Synthesis and degradation of ketone bodies 0.440869565 0.746047431 0.670527671 kegg kegg NA NA no no no no no no RNA polymerase Taurine and hypotaurine metabolism 0.410434783 0 0 kegg kegg NA NA no no no no no no RNA polymerase Terpenoid backbone biosynthesis 0.682608696 0.559288538 0.74002574 kegg kegg NA NA no no no no no no RNA polymerase Thiamine metabolism 0 0.501976285 0 kegg kegg NA NA no no no no no no RNA polymerase Tryptophan metabolism 0 0 0.510682111 kegg kegg NA NA no no no no up no RNA polymerase Tyrosine metabolism 0 0.633399209 0.42033462 kegg kegg NA NA no no no no no no RNA polymerase Ubiquinone and other terpenoid-quinone biosynthesis 0 0.646245059 0.746460746 kegg kegg NA NA no no no no no no RNA polymerase "Valine, leucine and isoleucine degradation" 0 0.694664032 0.651737452 kegg kegg NA NA no no no no no no RNA polymerase Various types of N-glycan biosynthesis 0.695652174 0.687747036 0.586357786 kegg kegg NA NA no no no no no no RNA transport 2-Oxocarboxylic acid metabolism 0 0.418972332 0 kegg kegg NA NA no no no no no no RNA transport ABC transporters 0.549565217 -0.444664032 0 kegg kegg NA NA no no no no up up RNA transport "Alanine, aspartate and glutamate metabolism" 0 -0.531620553 0 kegg kegg NA NA no no no no no no RNA transport alpha-Linolenic acid metabolism 0 -0.711462451 0 kegg kegg NA NA no no no no no no RNA transport Amino sugar and nucleotide sugar metabolism 0.408695652 0 0 kegg kegg NA NA no no no no no no RNA transport Aminoacyl-tRNA biosynthesis 0.566956522 0 0 kegg kegg NA NA no no no no no no RNA transport Arginine and proline metabolism 0 -0.538537549 0 kegg kegg NA NA no no no no up no RNA transport Arginine biosynthesis 0 -0.502964427 0 kegg kegg NA NA no no no no no no RNA transport Bacteroides 0 0.501976285 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up RNA transport Butanoate metabolism 0.490434783 0.588932806 0.610810811 kegg kegg NA NA no no no no no no RNA transport Citrate cycle (TCA cycle) 0 0.558300395 0 kegg kegg NA NA no no no no no no RNA transport Cysteine and methionine metabolism 0.64173913 0.752964427 0.701415701 kegg kegg NA NA no no no no no no RNA transport Drug metabolism - cytochrome P450 0 0.53458498 0 kegg kegg NA NA no no no no no no RNA transport Drug metabolism - other enzymes 0 0.552371542 0 kegg kegg NA NA no no no no no no RNA transport EGFR tyrosine kinase inhibitor resistance 0.52 0.950592885 0.753667954 kegg kegg NA NA no no no no no no RNA transport Fatty acid biosynthesis 0 -0.533596838 0 kegg kegg NA NA no no no no no no RNA transport Fatty acid elongation 0 0 0.43011583 kegg kegg NA NA no no no no no no RNA transport Folate biosynthesis 0 0.416996047 0 kegg kegg NA NA no no no no no no RNA transport Fructose and mannose metabolism 0 -0.517786561 0 kegg kegg NA NA no no no no no no RNA transport Galactose metabolism 0 -0.549407115 0 kegg kegg NA NA no no no no no no RNA transport Glutathione metabolism 0 0.513833992 0 kegg kegg NA NA no no no no no no RNA transport Glycerolipid metabolism 0 -0.549407115 0 kegg kegg NA NA no no no no no up RNA transport Glycerophospholipid metabolism 0 -0.438735178 0 kegg kegg NA NA no no no no no up RNA transport Glycolysis / Gluconeogenesis 0.489565217 0.711462451 0 kegg kegg NA NA no no no no no no RNA transport Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.640316206 0 kegg kegg NA NA no no no no no no RNA transport Glycosaminoglycan degradation -0.433043478 -0.526679842 0 kegg kegg NA NA no no no no no up RNA transport Glycosphingolipid biosynthesis - lacto and neolacto series 0 -0.423913043 0 kegg kegg NA NA no no no no no no RNA transport Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.520869565 0 0 kegg kegg NA NA no no no no no no RNA transport Glyoxylate and dicarboxylate metabolism 0 -0.45256917 0 kegg kegg NA NA no no no no no no RNA transport Lysine degradation 0.566956522 0 0 kegg kegg NA NA no no no no no no RNA transport Metabolism of xenobiotics by cytochrome P450 0 0.48715415 0 kegg kegg NA NA no no no no no no RNA transport Mucin type O-glycan biosynthesis 0.546086957 0 0 kegg kegg NA NA no no no no no no RNA transport N-Glycan biosynthesis 0 0.545454545 0 kegg kegg NA NA no no no no no no RNA transport Nicotinate and nicotinamide metabolism 0 -0.644268775 0 kegg kegg NA NA no no no no no no RNA transport Nitrogen metabolism 0 -0.470355731 0 kegg kegg NA NA no no no no no no RNA transport One carbon pool by folate 0.445217391 0 0 kegg kegg NA NA no no no no no no RNA transport Other glycan degradation 0.42 0 0 kegg kegg NA NA no no no no no no RNA transport Oxidative phosphorylation 0 0.543478261 0 kegg kegg NA NA no no no no no no RNA transport Pantothenate and CoA biosynthesis 0 -0.672924901 0 kegg kegg NA NA no no no no no dn RNA transport Parabacteroides 0 0 -0.525516444 kegg Genus NA 4.19E-05 no no no no up up RNA transport Pentose and glucuronate interconversions 0.405217391 0.559288538 0.409266409 kegg kegg NA NA no no no no no no RNA transport Pentose phosphate pathway 0 -0.429841897 0 kegg kegg NA NA no no no no no no RNA transport Platinum drug resistance 0.405217391 0 0 kegg kegg NA NA no no no no no no RNA transport Primary bile acid biosynthesis 0.432173913 0 0 kegg kegg NA NA no no no no no no RNA transport Propanoate metabolism 0.634782609 0.767786561 0.697297297 kegg kegg NA NA no no no no no no RNA transport Pyruvate metabolism 0.575652174 0.7756917 0.554697555 kegg kegg NA NA no no no no no no RNA transport Retinol metabolism 0.43826087 0 0 kegg kegg NA NA no no no no no no RNA transport Ribosome 0 0.817193676 0.61003861 kegg kegg NA NA no no no no no no RNA transport Ribosome biogenesis in eukaryotes 0.56 0 0.41003861 kegg kegg NA NA no no no no no no RNA transport Roseburia -0.50173913 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no RNA transport Sphingolipid metabolism -0.530434783 0 0 kegg kegg NA NA no no no no no no RNA transport Starch and sucrose metabolism 0 -0.633399209 -0.543371943 kegg kegg NA NA no no no no no no RNA transport Synthesis and degradation of ketone bodies 0.48173913 0 0 kegg kegg NA NA no no no no no no RNA transport Taurine and hypotaurine metabolism 0 -0.421936759 0 kegg kegg NA NA no no no no no no RNA transport Thiamine metabolism 0.567826087 0.736166008 0 kegg kegg NA NA no no no no no no RNA transport Tryptophan metabolism 0 0 0.419305019 kegg kegg NA NA no no no no up no RNA transport "Valine, leucine and isoleucine degradation" 0.497391304 0 0.410553411 kegg kegg NA NA no no no no no no RNA transport Various types of N-glycan biosynthesis 0.523478261 0.476284585 0 kegg kegg NA NA no no no no no no Roseburia Collinsella 0 0.621778448 0 butyrate-producing Genus Genus 0.495 0.128 no no no no no no Roseburia Coprococcus 0 0.709618544 0 butyrate-producing butyrate-producing Genus Genus 0.495 0.612 no no no no no no Roseburia Methanosphaera 0 -0.42081542 0 butyrate-producing Genus Genus 0.495 0.0703 no no no no no no Ruminococcus Anaerotruncus 0 -0.426734202 0 acetate-producing Genus Genus 0.335 0.904 no no no no no no Salivary secretion 2-Oxocarboxylic acid metabolism 0 0 -0.505534106 kegg kegg NA NA no no no no no no Salivary secretion ABC transporters -0.727826087 0 -0.556756757 kegg kegg NA NA no no no no up up Salivary secretion Adherens junction 0 0.592885375 0 kegg kegg NA NA no no no no no no Salivary secretion Adipocytokine signaling pathway 0 -0.462450593 0 kegg kegg NA NA no no no no no no Salivary secretion Adrenergic signaling in cardiomyocytes 0.497391304 0 0 kegg kegg NA NA no no no no no up Salivary secretion Aldosterone synthesis and secretion 0.587826087 0 0.435521236 kegg kegg NA NA no no no no up up Salivary secretion Alistipes 0 -0.43487008 0 kegg Genus NA 0.0114 no no no no up no Salivary secretion alpha-Linolenic acid metabolism -0.411304348 0 -0.415958816 kegg kegg NA NA no no no no no no Salivary secretion AMPK signaling pathway 0 0 0.458687259 kegg kegg NA NA no no no no no no Salivary secretion Ascorbate and aldarate metabolism 0 0 -0.565250965 kegg kegg NA NA no no no no no no Salivary secretion Autophagy - animal 0 -0.518774704 0 kegg kegg NA NA no no no no no no Salivary secretion Autophagy - other -0.427826087 -0.640316206 0 kegg kegg NA NA no no no no no no Salivary secretion Base excision repair -0.480869565 0 0 kegg kegg NA NA no no no no no no Salivary secretion Butyricicoccus -0.409204996 0 0 butyrate-producing kegg Genus NA 0.852 no no no no no no Salivary secretion C-type lectin receptor signaling pathway 0 -0.434782609 0 kegg kegg NA NA no no no no no no Salivary secretion Calcium signaling pathway 0.466956522 0 0 kegg kegg NA NA no no no no up up Salivary secretion cAMP signaling pathway 0 0 0.408751609 yes kegg kegg NA NA no no no no up up Salivary secretion Circadian entrainment 0.67826087 0.780632411 0.718918919 kegg kegg NA NA no no no no up up Salivary secretion Citrate cycle (TCA cycle) 0 0 -0.536679537 kegg kegg NA NA no no no no no no Salivary secretion Cortisol synthesis and secretion 0.494782609 0 0.548005148 kegg kegg NA NA no no no no no up Salivary secretion Cushing syndrome 0.427826087 0 0 kegg kegg NA NA no no no no no up Salivary secretion DNA replication -0.407826087 0 -0.51994852 kegg kegg NA NA no no no no no no Salivary secretion Dopaminergic synapse 0 0.633399209 0 kegg kegg NA NA no no no no up no Salivary secretion Drug metabolism - other enzymes 0 0 -0.427799228 kegg kegg NA NA no no no no no no Salivary secretion Endocrine and other factor-regulated calcium reabsorption 0.706956522 0.497035573 0.655598456 kegg kegg NA NA no no no no no no Salivary secretion Endocrine resistance 0.412173913 0 0.55032175 kegg kegg NA NA no no no no no no Salivary secretion Estrogen signaling pathway 0 0 0.52046332 kegg kegg NA NA no no no no no no Salivary secretion Ether lipid metabolism 0 0 -0.455598456 kegg kegg NA NA no no no no no no Salivary secretion Fatty acid degradation 0 -0.41798419 0 kegg kegg NA NA no no no no no no Salivary secretion Ferroptosis 0.488695652 0 0.417245817 kegg kegg NA NA no no no no no no Salivary secretion Focal adhesion 0.416521739 0.550395257 0 kegg kegg NA NA no no no no up up Salivary secretion Folate biosynthesis -0.449565217 0 -0.535135135 kegg kegg NA NA no no no no no no Salivary secretion Galactose metabolism 0 0 -0.466666667 kegg kegg NA NA no no no no no no Salivary secretion Gap junction 0.770434783 0 0.649163449 kegg kegg NA NA no no no no no no Salivary secretion Glutamatergic synapse 0.833913043 0 0.717631918 kegg kegg NA NA no no no no up up Salivary secretion Glycerolipid metabolism -0.542608696 0 -0.636293436 kegg kegg NA NA no no no no no up Salivary secretion Glycerophospholipid metabolism -0.486956522 0 -0.540540541 kegg kegg NA NA no no no no no up Salivary secretion "Glycine, serine and threonine metabolism" 0 0 0.422393822 kegg kegg NA NA no no no no up no Salivary secretion Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.678249678 kegg kegg NA NA no no no no no no Salivary secretion Glycosaminoglycan biosynthesis - keratan sulfate 0 0 -0.406177606 kegg kegg NA NA no no no no no no Salivary secretion Glycosaminoglycan degradation 0 0 -0.562676963 kegg kegg NA NA no no no no no up Salivary secretion Glycosphingolipid biosynthesis - globo and isoglobo series 0.435652174 0 0 kegg kegg NA NA no no no no no no Salivary secretion GnRH secretion 0 0 -0.402831403 kegg kegg NA NA no no no no up up Salivary secretion GnRH signaling pathway 0.656521739 0 0.567824968 kegg kegg NA NA no no no no no no Salivary secretion "Growth hormone synthesis, secretion and action" 0 0 0.438610039 kegg kegg NA NA no no no no no no Salivary secretion Hedgehog signaling pathway 0 0 -0.447619048 kegg kegg NA NA no no no no no no Salivary secretion Hippo signaling pathway 0 0.495059289 0 kegg kegg NA NA no no no no no no Salivary secretion Hippo signaling pathway - multiple species 0 0 -0.42033462 kegg kegg NA NA no no no no no no Salivary secretion Inflammatory mediator regulation of TRP channels 0.585217391 0.584980237 0.438867439 kegg kegg NA NA no no no no no no Salivary secretion Inositol phosphate metabolism -0.584347826 0 -0.467953668 kegg kegg NA NA no no no no no no Salivary secretion Insulin resistance -0.473043478 -0.483201581 0 kegg kegg NA NA no no no no no no Salivary secretion Insulin secretion 0.451304348 0 0.518404118 yes kegg kegg NA NA no no no no up up Salivary secretion JAK-STAT signaling pathway 0 -0.459486166 0 kegg kegg NA NA no no no no no no Salivary secretion Leukocyte transendothelial migration 0.433043478 0 0 kegg kegg NA NA no no no no no no Salivary secretion Long-term depression 0.703478261 0 0.675160875 kegg kegg NA NA no no no no no no Salivary secretion Lysine degradation -0.586956522 0 -0.50990991 kegg kegg NA NA no no no no no no Salivary secretion Mannose type O-glycan biosynthesis 0 0 -0.507335907 kegg kegg NA NA no no no no no no Salivary secretion MAPK signaling pathway 0 -0.548418972 -0.47001287 kegg kegg NA NA no no no no no no Salivary secretion Maturity onset diabetes of the young 0 0 -0.470785071 kegg kegg NA NA no no no no up no Salivary secretion Melanogenesis 0.628695652 0.532608696 0.51016731 kegg kegg NA NA no no no no no no Salivary secretion Mucin type O-glycan biosynthesis 0 -0.578063241 0 kegg kegg NA NA no no no no no no Salivary secretion Necroptosis 0 0 0.44967825 kegg kegg NA NA no no no no no no Salivary secretion Neurotrophin signaling pathway 0 -0.482213439 0 kegg kegg NA NA no no no no no no Salivary secretion NF-kappa B signaling pathway -0.696521739 -0.502964427 0 kegg kegg NA NA no no no no no no Salivary secretion NOD-like receptor signaling pathway 0 -0.480237154 0 kegg kegg NA NA no no no no no no Salivary secretion Non-alcoholic fatty liver disease 0 0.428853755 0 kegg kegg NA NA no no no no no no Salivary secretion Notch signaling pathway 0 0 -0.614929215 kegg kegg NA NA no no no no no no Salivary secretion One carbon pool by folate 0 0 -0.433462033 kegg kegg NA NA no no no no no no Salivary secretion Oscillospira 0 -0.493083004 0 LPS-producing kegg Genus NA 0.62 no no no no no no Salivary secretion Other glycan degradation -0.535652174 0 -0.454826255 kegg kegg NA NA no no no no no no Salivary secretion Other types of O-glycan biosynthesis -0.412173913 0 -0.453796654 kegg kegg NA NA no no no no no no Salivary secretion Ovarian steroidogenesis 0.644347826 0.539525692 0.731274131 kegg kegg NA NA no no no no up up Salivary secretion Oxytocin signaling pathway 0.433043478 0.714426877 0.568082368 kegg kegg NA NA no no no no no no Salivary secretion "Parathyroid hormone synthesis, secretion and action" 0 0 0.486486486 kegg kegg NA NA no no no no no no Salivary secretion Pentose and glucuronate interconversions 0 0 -0.428571429 kegg kegg NA NA no no no no no no Salivary secretion Phosphatidylinositol signaling system 0 0 -0.433462033 kegg kegg NA NA no no no no no no Salivary secretion Phototransduction 0.476521739 0 0 kegg kegg NA NA no no no no no no Salivary secretion PI3K-Akt signaling pathway -0.562608696 0 0 yes kegg kegg NA NA no no no no up up Salivary secretion Platelet activation 0.554782609 0.691699605 0 kegg kegg NA NA no no no no no no Salivary secretion Platinum drug resistance 0 -0.422924901 0 kegg kegg NA NA no no no no no no Salivary secretion PPAR signaling pathway 0 -0.523715415 0 kegg kegg NA NA no no no no no no Salivary secretion Progesterone-mediated oocyte maturation 0 -0.456521739 -0.416988417 kegg kegg NA NA no no no no no no Salivary secretion Proteasome 0 0 -0.518146718 kegg kegg NA NA no no no no no no Salivary secretion Pyrimidine metabolism 0 0 -0.43037323 kegg kegg NA NA no no no no no no Salivary secretion Rap1 signaling pathway 0.47826087 0.681818182 0 kegg kegg NA NA no no no no no no Salivary secretion Regulation of actin cytoskeleton 0 0.419960474 0 kegg kegg NA NA no no no no no no Salivary secretion Regulation of lipolysis in adipocytes 0.659130435 0.476284585 0.668725869 kegg kegg NA NA no no no no no no Salivary secretion Renin secretion 0.722608696 0.648221344 0.758558559 kegg kegg NA NA no no no no no no Salivary secretion Retinol metabolism 0 0 -0.406949807 kegg kegg NA NA no no no no no no Salivary secretion Retrograde endocannabinoid signaling 0 0.498023715 0 kegg kegg NA NA no no no no no up Salivary secretion Ribosome biogenesis in eukaryotes 0 0 -0.427027027 kegg kegg NA NA no no no no no no Salivary secretion RIG-I-like receptor signaling pathway -0.468695652 -0.576086957 0 kegg kegg NA NA no no no no no no Salivary secretion RNA degradation 0 0 -0.444015444 kegg kegg NA NA no no no no no no Salivary secretion RNA polymerase 0 0 -0.506821107 kegg kegg NA NA no no no no no no Salivary secretion RNA transport -0.446956522 0 0 kegg kegg NA NA no no no no no no Salivary secretion Selenocompound metabolism -0.545217391 0 -0.477992278 kegg kegg NA NA no no no no no no Salivary secretion Serotonergic synapse 0.548695652 0.501976285 0.635006435 kegg kegg NA NA no no no no no no Salivary secretion SNARE interactions in vesicular transport -0.690434783 -0.469367589 0 kegg kegg NA NA no no no no no no Salivary secretion Spliceosome -0.453043478 -0.503952569 0 kegg kegg NA NA no no no no no no Salivary secretion Steroid hormone biosynthesis 0 0 -0.597683398 kegg kegg NA NA no no no no no no Salivary secretion T cell receptor signaling pathway -0.486956522 -0.765810277 0 kegg kegg NA NA no no no no no no Salivary secretion Taste transduction 0 0 -0.593564994 kegg kegg NA NA no no no no no up Salivary secretion Terpenoid backbone biosynthesis 0 0 -0.589446589 kegg kegg NA NA no no no no no no Salivary secretion Th17 cell differentiation 0 -0.485177866 0 kegg kegg NA NA no no no no no no Salivary secretion Thiamine metabolism -0.506956522 0 0 kegg kegg NA NA no no no no no no Salivary secretion Thyroid hormone signaling pathway 0.408695652 0.516798419 0 kegg kegg NA NA no no no no no no Salivary secretion Thyroid hormone synthesis 0.552173913 0 0.559073359 kegg kegg NA NA no no no no no no Salivary secretion Tight junction 0 0.494071146 0 kegg kegg NA NA no no no no no no Salivary secretion TNF signaling pathway 0 -0.453557312 0 kegg kegg NA NA no no no no no no Salivary secretion Type II diabetes mellitus 0 -0.420948617 0 kegg kegg NA NA no no no no no no Salivary secretion Ubiquinone and other terpenoid-quinone biosynthesis 0 0 -0.406949807 kegg kegg NA NA no no no no no no Salivary secretion Various types of N-glycan biosynthesis 0 0 -0.417503218 kegg kegg NA NA no no no no no no Salivary secretion Vascular smooth muscle contraction 0.465217391 0.599802372 0.568854569 kegg kegg NA NA no no no no no no Salivary secretion Vasopressin-regulated water reabsorption 0.631304348 0.617588933 0.634234234 kegg kegg NA NA no no no no no no Salivary secretion Wnt signaling pathway 0 0 -0.483140283 kegg kegg NA NA no no no no no no Salmonella infection ABC transporters 0 0 -0.451737452 kegg kegg NA NA no no no no up up Salmonella infection Adherens junction 0 0 0.645817246 kegg kegg NA NA no no no no no no Salmonella infection Adipocytokine signaling pathway -0.431304348 0 0 kegg kegg NA NA no no no no no no Salmonella infection Adrenergic signaling in cardiomyocytes 0 -0.60770751 0 kegg kegg NA NA no no no no no up Salmonella infection Aldosterone synthesis and secretion -0.613043478 -0.816205534 0 kegg kegg NA NA no no no no up up Salmonella infection alpha-Linolenic acid metabolism 0.586956522 0 0 kegg kegg NA NA no no no no no no Salmonella infection Amino sugar and nucleotide sugar metabolism 0.48 0 0 kegg kegg NA NA no no no no no no Salmonella infection Amphetamine addiction -0.517391304 -0.7243083 0 kegg kegg NA NA no no no no no no Salmonella infection AMPK signaling pathway -0.487826087 -0.652173913 0 kegg kegg NA NA no no no no no no Salmonella infection Amyotrophic lateral sclerosis -0.444347826 -0.451581028 0 kegg kegg NA NA no no no no no no Salmonella infection Antifolate resistance 0 -0.41798419 -0.446589447 kegg kegg NA NA no no no no no no Salmonella infection Antigen processing and presentation 0.568695652 0.543478261 0.416473616 kegg kegg NA NA no no no no no no Salmonella infection Apoptosis 0.56173913 0.509881423 0.584298584 kegg kegg NA NA no no no no no no Salmonella infection Autophagy - other 0 0 -0.453796654 kegg kegg NA NA no no no no no no Salmonella infection Bacterial invasion of epithelial cells 0.491304348 0 0.756756757 kegg kegg NA NA no no no no no no Salmonella infection Basal transcription factors 0 -0.517786561 -0.496267696 kegg kegg NA NA no no no no no no Salmonella infection Base excision repair 0 -0.482213439 0 kegg kegg NA NA no no no no no no Salmonella infection beta-Alanine metabolism 0.465217391 0.415019763 0.436550837 kegg kegg NA NA no no no no no no Salmonella infection Bile secretion 0 -0.586956522 0 kegg kegg NA NA no no no no no no Salmonella infection Biosynthesis of amino acids 0.572173913 0.735177866 0.644787645 kegg kegg NA NA no no no no no no Salmonella infection Biosynthesis of cofactors 0 -0.580039526 0 kegg kegg NA NA no no no no no no Salmonella infection Biosynthesis of unsaturated fatty acids 0.460869565 0 0 kegg kegg NA NA no no no no no no Salmonella infection Calcium signaling pathway -0.544347826 -0.574110672 0 kegg kegg NA NA no no no no up up Salmonella infection Carbon metabolism 0.58 0.78458498 0.692921493 kegg kegg NA NA no no no no no no Salmonella infection Cell adhesion molecules 0.413043478 0.804347826 0.537451737 kegg kegg NA NA no no no no no no Salmonella infection Cell cycle 0 -0.558300395 -0.445302445 kegg kegg NA NA no no no no no no Salmonella infection Cellular senescence 0 0.570158103 0 kegg kegg NA NA no no no no no no Salmonella infection cGMP-PKG signaling pathway 0 0.617588933 0 kegg kegg NA NA no no no no no no Salmonella infection Chemokine signaling pathway 0 0.432806324 0 kegg kegg NA NA no no no no no no Salmonella infection Cholesterol metabolism 0 0.802371542 0 yes kegg kegg NA NA no no no no no up Salmonella infection Circadian rhythm 0 -0.706521739 -0.627541828 kegg kegg NA NA no no no no no no Salmonella infection Clostridium 0 0.415672633 0 kegg Genus NA 0.925 no no no no no no Salmonella infection Cocaine addiction -0.632173913 -0.801383399 0 kegg kegg NA NA no no no no no no Salmonella infection Complement and coagulation cascades 0.527826087 0.574110672 0.688545689 kegg kegg NA NA no no no no no no Salmonella infection Coprococcus 0 0 0.414569793 butyrate-producing kegg Genus NA 0.612 no no no no no no Salmonella infection Cortisol synthesis and secretion -0.667826087 -0.880434783 0 kegg kegg NA NA no no no no no up Salmonella infection Cushing syndrome -0.570434783 -0.920948617 0 kegg kegg NA NA no no no no no up Salmonella infection Cytokine-cytokine receptor interaction 0 0 0.548777349 kegg kegg NA NA no no no no no no Salmonella infection Dopaminergic synapse 0 -0.595849802 0 kegg kegg NA NA no no no no up no Salmonella infection Drug metabolism - other enzymes 0.493043478 0 0 kegg kegg NA NA no no no no no no Salmonella infection Endocrine and other factor-regulated calcium reabsorption -0.491304348 -0.68083004 0 kegg kegg NA NA no no no no no no Salmonella infection Endocrine resistance -0.630434783 -0.825098814 0 kegg kegg NA NA no no no no no no Salmonella infection Endocytosis 0.46 0.755928854 0 kegg kegg NA NA no no no no no no Salmonella infection Epithelial cell signaling in Helicobacter pylori infection 0 0.56027668 0 kegg kegg NA NA no no no no no no Salmonella infection Ether lipid metabolism -0.52173913 -0.601778656 -0.412612613 kegg kegg NA NA no no no no no no Salmonella infection Eubacterium 0 0 -0.423323391 kegg Genus NA 0.0692 no no no no no no Salmonella infection Fanconi anemia pathway 0 -0.43972332 0 kegg kegg NA NA no no no no no no Salmonella infection Fat digestion and absorption 0 0.494071146 0 yes kegg kegg NA NA no no no no up up Salmonella infection Fatty acid degradation 0.453043478 0 0 kegg kegg NA NA no no no no no no Salmonella infection Fatty acid elongation 0.533043478 0.481225296 0.425997426 kegg kegg NA NA no no no no no no Salmonella infection Fatty acid metabolism 0.492173913 0.445652174 0 kegg kegg NA NA no no no no no no Salmonella infection Fc gamma R-mediated phagocytosis 0.806086957 0.684782609 0.631402831 kegg kegg NA NA no no no no no no Salmonella infection Focal adhesion 0.422608696 0 0.653281853 kegg kegg NA NA no no no no up up Salmonella infection Galactose metabolism 0.426086957 0 0 kegg kegg NA NA no no no no no no Salmonella infection Gap junction 0 -0.5 0 kegg kegg NA NA no no no no no no Salmonella infection Gastric acid secretion 0 0 0.534362934 kegg kegg NA NA no no no no no no Salmonella infection Glucagon signaling pathway -0.43826087 -0.726284585 -0.422393822 kegg kegg NA NA no no no no no no Salmonella infection Glutathione metabolism 0 -0.45256917 0 kegg kegg NA NA no no no no no no Salmonella infection Glycerophospholipid metabolism -0.486086957 -0.470355731 -0.543886744 kegg kegg NA NA no no no no no up Salmonella infection "Glycine, serine and threonine metabolism" 0 -0.592885375 0 kegg kegg NA NA no no no no up no Salmonella infection Glycolysis / Gluconeogenesis 0.513913043 0 0.504247104 kegg kegg NA NA no no no no no no Salmonella infection Glycosaminoglycan biosynthesis - keratan sulfate -0.609565217 0 0 kegg kegg NA NA no no no no no no Salmonella infection Glycosaminoglycan degradation 0 0.610671937 0 kegg kegg NA NA no no no no no up Salmonella infection Glycosphingolipid biosynthesis - lacto and neolacto series -0.484347826 0 0 kegg kegg NA NA no no no no no no Salmonella infection Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.586956522 -0.43011583 kegg kegg NA NA no no no no no no Salmonella infection GnRH signaling pathway -0.604347826 -0.837944664 0 kegg kegg NA NA no no no no no no Salmonella infection "Growth hormone synthesis, secretion and action" -0.528695652 -0.589920949 0 kegg kegg NA NA no no no no no no Salmonella infection Hedgehog signaling pathway -0.409565217 -0.414031621 -0.473616474 kegg kegg NA NA no no no no no no Salmonella infection Hematopoietic cell lineage 0 0 0.465637066 kegg kegg NA NA no no no no no no Salmonella infection Hippo signaling pathway 0 0 0.575546976 kegg kegg NA NA no no no no no no Salmonella infection Huntington disease -0.472173913 -0.421936759 0 kegg kegg NA NA no no no no no no Salmonella infection IL-17 signaling pathway 0 0.590909091 0 kegg kegg NA NA no no no no no no Salmonella infection Inflammatory mediator regulation of TRP channels -0.410434783 -0.623517787 0 kegg kegg NA NA no no no no no no Salmonella infection Insulin resistance 0 0 -0.625740026 kegg kegg NA NA no no no no no no Salmonella infection Insulin secretion -0.699130435 -0.880434783 0 yes kegg kegg NA NA no no no no up up Salmonella infection Leukocyte transendothelial migration 0.465217391 0.492094862 0.886743887 kegg kegg NA NA no no no no no no Salmonella infection Long-term depression -0.529565217 -0.467391304 0 kegg kegg NA NA no no no no no no Salmonella infection Longevity regulating pathway -0.709565217 -0.53458498 0 kegg kegg NA NA no no no no no no Salmonella infection Longevity regulating pathway - multiple species 0.405217391 0.549407115 0 kegg kegg NA NA no no no no no no Salmonella infection Lysine degradation 0 -0.535573123 -0.572715573 kegg kegg NA NA no no no no no no Salmonella infection Lysosome 0 0.733201581 0.405405405 kegg kegg NA NA no no no no no no Salmonella infection Mannose type O-glycan biosynthesis -0.571304348 -0.453557312 -0.544916345 kegg kegg NA NA no no no no no no Salmonella infection Maturity onset diabetes of the young -0.54 -0.45256917 0 kegg kegg NA NA no no no no up no Salmonella infection Melanogenesis 0 -0.619565217 0 kegg kegg NA NA no no no no no no Salmonella infection Metabolism of xenobiotics by cytochrome P450 0.414782609 0 0 kegg kegg NA NA no no no no no no Salmonella infection Mineral absorption -0.56173913 -0.414031621 0 kegg kegg NA NA no no no no no no Salmonella infection Mitophagy - animal -0.646956522 -0.485177866 0 kegg kegg NA NA no no no no no no Salmonella infection Morphine addiction -0.439130435 -0.683794466 0 kegg kegg NA NA no no no no up up Salmonella infection mRNA surveillance pathway -0.510434783 -0.621541502 -0.592277992 kegg kegg NA NA no no no no no no Salmonella infection Mucin type O-glycan biosynthesis 0.506086957 0 0 kegg kegg NA NA no no no no no no Salmonella infection Natural killer cell mediated cytotoxicity 0.516521739 0.677865613 0 kegg kegg NA NA no no no no no no Salmonella infection Necroptosis -0.540869565 0 0 kegg kegg NA NA no no no no no no Salmonella infection Neuroactive ligand-receptor interaction 0.744347826 0.721343874 0.562934363 kegg kegg NA NA no no no up up up Salmonella infection Neutrophil extracellular trap formation 0.666086957 0.639328063 0.686229086 kegg kegg NA NA no no no no no no Salmonella infection Nicotinate and nicotinamide metabolism 0.442608696 0 0 kegg kegg NA NA no no no no no no Salmonella infection Nicotine addiction 0 -0.450592885 0 kegg kegg NA NA no no no no up up Salmonella infection NOD-like receptor signaling pathway 0.611304348 0.441699605 0 kegg kegg NA NA no no no no no no Salmonella infection Non-alcoholic fatty liver disease -0.427826087 -0.416996047 0 kegg kegg NA NA no no no no no no Salmonella infection Non-homologous end-joining 0.539130435 0 0 kegg kegg NA NA no no no no no no Salmonella infection Notch signaling pathway 0 0 -0.405148005 kegg kegg NA NA no no no no no no Salmonella infection Odoribacter 0 0.526004585 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Salmonella infection Olfactory transduction 0.548695652 0.600790514 0.506306306 kegg kegg NA NA no no no no no no Salmonella infection Oscillospira -0.429565217 0 0 LPS-producing kegg Genus NA 0.62 no no no no no no Salmonella infection Osteoclast differentiation 0.574782609 0.568181818 0 kegg kegg NA NA no no no no no no Salmonella infection Other types of O-glycan biosynthesis -0.523478261 -0.696640316 -0.585585586 kegg kegg NA NA no no no no no no Salmonella infection Ovarian steroidogenesis 0 -0.639328063 0 kegg kegg NA NA no no no no up up Salmonella infection Oxytocin signaling pathway 0.405217391 0 0.69009009 kegg kegg NA NA no no no no no no Salmonella infection p53 signaling pathway -0.470434783 -0.559288538 -0.686743887 kegg kegg NA NA no no no no no no Salmonella infection Pancreatic secretion -0.468695652 -0.57312253 0 kegg kegg NA NA no no no no no no Salmonella infection Pantothenate and CoA biosynthesis 0.525217391 0 0 kegg kegg NA NA no no no no no dn Salmonella infection Paraprevotella 0.476704646 0 0 kegg Genus NA 0.118 no no no no no no Salmonella infection "Parathyroid hormone synthesis, secretion and action" -0.520869565 -0.546442688 0 kegg kegg NA NA no no no no no no Salmonella infection Parkinson disease -0.592173913 -0.43972332 0 kegg kegg NA NA no no no no no no Salmonella infection Pathogenic Escherichia coli infection 0.773043478 0.882411067 0.855341055 kegg kegg NA NA no no no no no no Salmonella infection Pathways of neurodegeneration - multiple diseases -0.609565217 -0.467391304 0 kegg kegg NA NA no no no no no no Salmonella infection Pentose phosphate pathway 0.48173913 0.7243083 0.44993565 kegg kegg NA NA no no no no no no Salmonella infection Peroxisome 0.434782609 0.447628458 0 kegg kegg NA NA no no no no no no Salmonella infection Phagosome 0.44173913 0.816205534 0.656628057 kegg kegg NA NA no no no no no no Salmonella infection Phenylalanine metabolism 0 0 0.422908623 kegg kegg NA NA no no no no no no Salmonella infection Phosphatidylinositol signaling system -0.451304348 -0.488142292 -0.525096525 kegg kegg NA NA no no no no no no Salmonella infection Platelet activation 0 0 0.675933076 kegg kegg NA NA no no no no no no Salmonella infection Porphyrin and chlorophyll metabolism 0 -0.498023715 0 kegg kegg NA NA no no no no no no Salmonella infection PPAR signaling pathway 0 0.550395257 0 kegg kegg NA NA no no no no no no Salmonella infection Primary bile acid biosynthesis 0 0 0.521750322 kegg kegg NA NA no no no no no no Salmonella infection Protein digestion and absorption 0 0.440711462 0 yes kegg kegg NA NA no no no no up up Salmonella infection Purine metabolism -0.452173913 -0.596837945 0 kegg kegg NA NA no no no no no no Salmonella infection Pyrimidine metabolism 0 0 -0.483655084 kegg kegg NA NA no no no no no no Salmonella infection Rap1 signaling pathway 0 0 0.656628057 kegg kegg NA NA no no no no no no Salmonella infection Ras signaling pathway 0 0 -0.443758044 yes kegg kegg NA NA no no no no up up Salmonella infection Regulation of actin cytoskeleton 0.58 0 0.545688546 kegg kegg NA NA no no no no no no Salmonella infection Regulation of lipolysis in adipocytes 0 -0.694664032 0 kegg kegg NA NA no no no no no no Salmonella infection Relaxin signaling pathway -0.506086957 0 0 kegg kegg NA NA no no no no no no Salmonella infection Renin secretion 0 -0.496047431 0 kegg kegg NA NA no no no no no no Salmonella infection Renin-angiotensin system 0.597391304 0.663043478 0.43989704 kegg kegg NA NA no no no no no no Salmonella infection Retinol metabolism 0.611304348 0 0 kegg kegg NA NA no no no no no no Salmonella infection Ribosome -0.615652174 0 0 kegg kegg NA NA no no no no no no Salmonella infection Ribosome biogenesis in eukaryotes 0 -0.482213439 -0.452252252 kegg kegg NA NA no no no no no no Salmonella infection RNA degradation -0.502608696 -0.447628458 -0.472586873 kegg kegg NA NA no no no no no no Salmonella infection RNA polymerase -0.433913043 -0.532608696 0 kegg kegg NA NA no no no no no no Salmonella infection Selenocompound metabolism 0 -0.466403162 -0.448648649 kegg kegg NA NA no no no no no no Salmonella infection Shigellosis -0.419130435 0 0 kegg kegg NA NA no no no no no no Salmonella infection Signaling pathways regulating pluripotency of stem cells 0 -0.5256917 0 kegg kegg NA NA no no no no no no Salmonella infection Sphingolipid signaling pathway 0 0.502964427 0 kegg kegg NA NA no no no no no no Salmonella infection Spliceosome 0 -0.418972332 -0.416731017 kegg kegg NA NA no no no no no no Salmonella infection Starch and sucrose metabolism 0.553043478 0 0 kegg kegg NA NA no no no no no no Salmonella infection Steroid hormone biosynthesis 0.476521739 0 0 kegg kegg NA NA no no no no no no Salmonella infection Synaptic vesicle cycle 0 0.678853755 0 kegg kegg NA NA no no no no up up Salmonella infection Taurine and hypotaurine metabolism 0 -0.467391304 -0.485714286 kegg kegg NA NA no no no no no no Salmonella infection Th1 and Th2 cell differentiation 0 0.497035573 0 kegg kegg NA NA no no no no no no Salmonella infection Th17 cell differentiation 0 0.494071146 0 kegg kegg NA NA no no no no no no Salmonella infection Thermogenesis -0.431304348 0 0 kegg kegg NA NA no no no no no no Salmonella infection Thyroid hormone synthesis -0.576521739 -0.755928854 0 kegg kegg NA NA no no no no no no Salmonella infection Tight junction 0 0 0.56962677 kegg kegg NA NA no no no no no no Salmonella infection Type I diabetes mellitus 0 0.704545455 0 kegg kegg NA NA no no no no no no Salmonella infection Ubiquitin mediated proteolysis -0.663478261 -0.556324111 0 kegg kegg NA NA no no no no no no Salmonella infection Vascular smooth muscle contraction -0.469565217 0 0 kegg kegg NA NA no no no no no no Salmonella infection Vasopressin-regulated water reabsorption -0.479130435 -0.626482213 0 kegg kegg NA NA no no no no no no Salmonella infection Vibrio cholerae infection 0 0 0.553410553 kegg kegg NA NA no no no no no no Salmonella infection Vitamin digestion and absorption -0.469565217 0 0 kegg kegg NA NA no no no no no no Salmonella infection Wnt signaling pathway 0 -0.470355731 -0.447876448 kegg kegg NA NA no no no no no no Sarcosine+blood 14:0/16:0-PC+blood 0 0 0.442735043 serum_choline serum_phospholipids 5.06E-05 0.0358 up up no no up no Sarcosine+blood 14:0/18:0-PC+blood 0 0 0.468034188 serum_choline serum_phospholipids 5.06E-05 0.00289 up up no up up no Sarcosine+blood 16:0-LPC+blood 0 0.536764706 0 serum_choline serum_phospholipids 5.06E-05 0.00456 up up no up up no Sarcosine+blood 16:0-LPE+blood 0.535338346 0 0.474188034 serum_choline serum_phospholipids 5.06E-05 0.0711 up up no up up no Sarcosine+blood 16:0/16:1-PC+blood 0 0 0.469401709 serum_choline serum_phospholipids 5.06E-05 0.00283 up up no up up no Sarcosine+blood 16:0/16:1-PI+blood 0 0 0.540512821 serum_choline serum_phospholipids 5.06E-05 0.262 up up no no no no Sarcosine+blood 16:0/18:2-PI+blood 0 0 0.545982906 serum_choline serum_phospholipids 5.06E-05 0.269 up up no no no no Sarcosine+blood 16:0/18:3-PC+blood 0 0 0.424273504 serum_choline serum_phospholipids 5.06E-05 0.00216 up up no no up up Sarcosine+blood 16:0/20:3-PC+blood 0 0 0.437948718 serum_choline serum_phospholipids 5.06E-05 5.43E-06 up up no no up up Sarcosine+blood 16:0/20:4-PI+blood 0 0 0.534358974 serum_choline serum_phospholipids 5.06E-05 0.558 up up no no no no Sarcosine+blood 16:1/16:1-PC+blood -0.446616541 0 0 serum_choline serum_phospholipids 5.06E-05 0.0177 up up no no no up Sarcosine+blood 18:0/20:3-PC+blood 0 0 0.624615385 serum_choline serum_phospholipids 5.06E-05 0.0682 up up no no up no Sarcosine+blood 18:0/22:6-PA+blood -0.580451128 0 0 serum_choline serum_phospholipids 5.06E-05 0.22 up up no no no no Sarcosine+blood 18:1/16:0-PI+blood 0 0 0.446153846 serum_choline serum_phospholipids 5.06E-05 0.793 up up no no no no Sarcosine+blood 18:1/18:0-PS+blood -0.44962406 -0.490196078 0 serum_choline serum_phospholipids 5.06E-05 0.193 up up no no no no Sarcosine+blood 18:1/18:1-PC+blood 0 0 0.467350427 serum_choline serum_phospholipids 5.06E-05 1.34E-05 up up no no up up Sarcosine+blood 18:2-LPA+blood -0.538345865 0 0 serum_choline serum_phospholipids 5.06E-05 0.00684 up up no dn no up Sarcosine+blood 18:3n3+blood 0 0 -0.417435897 serum_choline serum_fattyacid 5.06E-05 0.291 up up no no no no Sarcosine+blood 18:3n6+blood 0 0 0.570598291 serum_choline serum_fattyacid 5.06E-05 0.0463 up up no up no dn Sarcosine+blood 20:0-LPC+blood 0 -0.5 0 serum_choline serum_phospholipids 5.06E-05 0.199 up up no no no no Sarcosine+blood 20:0-LPE+blood 0 -0.600490196 0 serum_choline serum_phospholipids 5.06E-05 0.0615 up up no no no up Sarcosine+blood 20:0+blood 0 -0.664215686 0.443418803 yes serum_choline serum_fattyacid 5.06E-05 0.000278 up up no dn no up Sarcosine+blood 20:1-LPE+blood 0 -0.558823529 0 serum_choline serum_phospholipids 5.06E-05 0.465 up up no no no no Sarcosine+blood 20:2-LPE+blood -0.482706767 -0.715686275 0 serum_choline serum_phospholipids 5.06E-05 0.177 up up no no no no Sarcosine+blood 20:2/18:0-PC+blood 0 0 0.620512821 serum_choline serum_phospholipids 5.06E-05 0.0427 up up no no up no Sarcosine+blood 20:3-LPC+blood 0 0 0.707350427 serum_choline serum_phospholipids 5.06E-05 0.0292 up up no no up no Sarcosine+blood 20:3-LPE+blood 0 0 0.498119658 serum_choline serum_phospholipids 5.06E-05 0.084 up up no no up no Sarcosine+blood 20:3n6+blood 0 0 0.612307692 serum_choline serum_fattyacid 5.06E-05 0.0884 up up no up no no Sarcosine+blood 22:2-LPA+blood 0 0 0.478290598 serum_choline serum_phospholipids 5.06E-05 0.0443 up up no dn no no Sarcosine+blood 24:0+blood 0 -0.509803922 0 serum_choline serum_fattyacid 5.06E-05 0.034 up up no dn no up Sarcosine+blood ACA+stool 0 0 0.445536443 serum_choline stool_bileacids 5.06E-05 0.417 up up no no no no Sarcosine+blood acetic acid C2+blood 0 0 -0.464615385 serum_choline serum_scfa 5.06E-05 0.000193 up up no up dn no Sarcosine+blood Alistipes 0 -0.548130085 0 serum_choline Genus 5.06E-05 0.0114 up up no no up no Sarcosine+blood Allograft rejection 0 0 0.458461538 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Apoptosis 0.538596491 0 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Autoimmune thyroid disease 0 0 0.458461538 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Bifidobacterium -0.585182441 0 0 acetate-producing serum_choline Genus 5.06E-05 0.105 up up no no dn no Sarcosine+blood Butyricimonas -0.497106714 0 0 butyrate-producing serum_choline Genus 5.06E-05 0.17 up up no no no no Sarcosine+blood C-type lectin receptor signaling pathway 0 0 0.413076923 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood capric acid C6+blood 0 0 -0.474871795 serum_choline serum_scfa 5.06E-05 0.433 up up no no no no Sarcosine+blood Cellular senescence 0 0 0.424615385 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Choline+blood 0 0.531862745 0 serum_choline serum_choline 5.06E-05 0.0395 up up no no up no Sarcosine+blood Cocaine addiction 0 0 0.484615385 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Colorectal cancer 0 -0.511764706 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Creatinine+blood 0 0.659313725 0 serum_choline serum_choline 5.06E-05 0.437 up up no no no no Sarcosine+blood Cytosolic DNA-sensing pathway 0 0 0.514615385 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood d18:0-16:0-SM+blood 0 0 0.409230769 serum_choline serum_phospholipids 5.06E-05 0.202 up up no no no no Sarcosine+blood d18:1-16:0-SM+blood 0 0 0.431111111 serum_choline serum_phospholipids 5.06E-05 0.14 up up no no no no Sarcosine+blood DCA+stool -0.565934066 0 0 serum_choline stool_bileacids 5.06E-05 0.195 up up no no no no Sarcosine+blood DL-methionine sulfoxide+blood 0.473684211 0 0 serum_choline serum_aminoacids 5.06E-05 0.302 up up no no no no Sarcosine+blood DMG+blood 0 0.573529412 0 serum_choline serum_choline 5.06E-05 0.909 up up no no no no Sarcosine+blood ErbB signaling pathway 0 -0.538235294 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Estrogen signaling pathway 0 0 -0.426153846 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood FoxO signaling pathway 0 0 -0.608461538 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Gastric cancer 0 -0.594117647 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood GLCA+blood 0 0 -0.462609563 serum_choline serum_bileacids 5.06E-05 0.319 up up no no no no Sarcosine+blood GPC+blood 0 0.485294118 0 serum_choline serum_choline 5.06E-05 0.00427 up up no no up up Sarcosine+blood Graft-versus-host disease 0 0 0.432307692 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood HCA+blood 0.470899002 0 0 serum_choline serum_bileacids 5.06E-05 0.544 up up no no no no Sarcosine+blood HDCA+blood 0 0 -0.52316725 serum_choline serum_bileacids 5.06E-05 0.483 up up no no no no Sarcosine+blood Hepatitis C 0 0 0.402307692 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Human papillomavirus infection 0 0 0.477692308 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood iso-heptanoic acid C7+blood 0.476691729 0 0 serum_choline serum_mcfa 5.06E-05 0.00256 up up no up up no Sarcosine+blood iso-LCA+blood 0 0 -0.483504142 serum_choline serum_bileacids 5.06E-05 0.507 up up no no no no Sarcosine+blood iso-LCA+stool 0 0 -0.485714286 serum_choline stool_bileacids 5.06E-05 0.72 up up no no no no Sarcosine+blood isovaleric acid iso-C5+blood 0.52481203 0 0 serum_choline serum_scfa 5.06E-05 0.117 up up no no no no Sarcosine+blood Kaposi sarcoma-associated herpesvirus infection 0 0 0.496153846 serum_choline kegg 5.06E-05 NA up up no no no dn Sarcosine+blood L-Alanine+blood 0.694736842 0.850490196 0.612991453 yes serum_choline serum_aminoacids 5.06E-05 0.00138 up up no up up no Sarcosine+blood L-Arginine+blood 0 0.526960784 0 serum_choline serum_aminoacids 5.06E-05 0.316 up up no no no no Sarcosine+blood L-Asparagine+blood 0.487218045 0 0 serum_choline serum_aminoacids 5.06E-05 0.784 up up no no no no Sarcosine+blood L-Glutamic acid+blood 0 0.549019608 0 yes serum_choline serum_aminoacids 5.06E-05 6.20E-05 up up no up up no Sarcosine+blood L-Homocystine+blood 0 0 -0.495384615 serum_choline serum_aminoacids 5.06E-05 0.197 up up no no no no Sarcosine+blood L-Leucine+blood 0 0.745098039 0 yes serum_choline serum_aminoacids 5.06E-05 3.22E-05 up up no up up no Sarcosine+blood L-Methionine+blood 0 0.745098039 0 serum_choline serum_aminoacids 5.06E-05 0.626 up up no no no no Sarcosine+blood L-Ornithine+blood 0.538345865 0 0 serum_choline serum_aminoacids 5.06E-05 0.175 up up no no no no Sarcosine+blood L-Phenylalanine+blood 0 0.522058824 0 yes serum_choline serum_aminoacids 5.06E-05 0.0103 up up no up up no Sarcosine+blood L-Tryptophan+blood 0 0.634803922 0 serum_choline serum_aminoacids 5.06E-05 0.164 up up no no no no Sarcosine+blood lauric acid C12+blood 0 0 -0.467350427 serum_choline serum_mcfa 5.06E-05 0.015 up up no no dn dn Sarcosine+blood Longevity regulating pathway - multiple species 0 0 -0.540769231 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Methanobrevibacter 0 0 -0.404411013 serum_choline Genus 5.06E-05 0.629 up up no no no no Sarcosine+blood Neuroactive ligand-receptor interaction 0 0 -0.434615385 serum_choline kegg 5.06E-05 NA up up no up up up Sarcosine+blood Non-small cell lung cancer 0 -0.544117647 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood nonanoic acid C9+blood 0 0 -0.401025641 serum_choline serum_mcfa 5.06E-05 6.51E-11 up up no dn dn no Sarcosine+blood Oocyte meiosis -0.584210526 0 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Oxytocin signaling pathway 0.492982456 0 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Pancreatic cancer 0 -0.623529412 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Phenylacetic acid+stool 0 0 -0.521804511 serum_choline stool_cometabolism 5.06E-05 0.785 up up no no no no Sarcosine+blood Platinum drug resistance 0 0 -0.490769231 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Primary immunodeficiency 0 0 -0.552307692 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Progesterone-mediated oocyte maturation -0.540350877 0 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Proteasome -0.466666667 0 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Relaxin signaling pathway 0 0 0.485384615 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Renal cell carcinoma 0 -0.652941176 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Ribosome biogenesis in eukaryotes -0.536842105 0 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood RIG-I-like receptor signaling pathway 0 0 0.426153846 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Sphingolipid signaling pathway 0 -0.505882353 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Spinocerebellar ataxia -0.50877193 0 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Spliceosome -0.494736842 0 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood TNF signaling pathway 0 0 0.442307692 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Type I diabetes mellitus 0 0 0.453076923 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Vibrio cholerae infection 0 0.5 0 serum_choline kegg 5.06E-05 NA up up no no no no Sarcosine+blood Viral carcinogenesis 0 0 0.491538462 serum_choline kegg 5.06E-05 NA up up no no no no Selenocompound metabolism Ascorbate and aldarate metabolism 0 0 0.687001287 kegg kegg NA NA no no no no no no Selenocompound metabolism Citrate cycle (TCA cycle) 0 0 0.635521236 kegg kegg NA NA no no no no no no Selenocompound metabolism Cysteine and methionine metabolism 0 0 0.44015444 kegg kegg NA NA no no no no no no Selenocompound metabolism Fructose and mannose metabolism 0 0.457509881 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Histidine metabolism 0 0 0.403861004 kegg kegg NA NA no no no no no no Selenocompound metabolism Lysine degradation 0.654782609 0.758893281 0.735392535 kegg kegg NA NA no no no no no no Selenocompound metabolism Pentose and glucuronate interconversions 0 0 0.481595882 kegg kegg NA NA no no no no no no Selenocompound metabolism Pentose phosphate pathway 0 -0.503952569 0 kegg kegg NA NA no no no no no no Selenocompound metabolism Pyrimidine metabolism 0 0 0.576576577 kegg kegg NA NA no no no no no no Selenocompound metabolism Steroid biosynthesis 0.426086957 0 0.553153153 kegg kegg NA NA no no no no no no Selenocompound metabolism Steroid hormone biosynthesis 0 0 0.595624196 kegg kegg NA NA no no no no no no Selenocompound metabolism Synthesis and degradation of ketone bodies 0.426086957 0.639328063 0.646589447 kegg kegg NA NA no no no no no no Selenocompound metabolism Taurine and hypotaurine metabolism 0.648695652 0.596837945 0.565250965 kegg kegg NA NA no no no no no no Selenocompound metabolism Tryptophan metabolism 0 0 0.465122265 kegg kegg NA NA no no no no up no Selenocompound metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0 0.575098814 0.684942085 kegg kegg NA NA no no no no no no Selenocompound metabolism "Valine, leucine and isoleucine degradation" 0 0.425889328 0.587644788 kegg kegg NA NA no no no no no no Serine+blood 11-HETE+blood 0 0 0.406246789 serum_aminoacids serum_ARA 0.942 0.464 no no no no no no Serine+blood 14:0-LPC+blood -0.606015038 -0.62745098 -0.557606838 serum_aminoacids serum_phospholipids 0.942 0.00689 no no no up up no Serine+blood 14:0/16:0-PC+blood 0 -0.56127451 0 serum_aminoacids serum_phospholipids 0.942 0.0358 no no no no up no Serine+blood 14:0/18:0-PC+blood 0 -0.517156863 0 serum_aminoacids serum_phospholipids 0.942 0.00289 no no no up up no Serine+blood 14:0/18:2-PC+blood -0.657142857 -0.512254902 -0.643760684 serum_aminoacids serum_phospholipids 0.942 0.102 no no no no up no Serine+blood 14:0/20:4-PC+blood -0.470676692 0 -0.589059829 serum_aminoacids serum_phospholipids 0.942 0.486 no no no no no no Serine+blood 14:0+blood -0.508270677 0 -0.593162393 yes serum_aminoacids serum_fattyacid 0.942 0.00572 no no no up no dn Serine+blood 14:1/18:2-PG+blood 0 0 -0.620512821 serum_aminoacids serum_phospholipids 0.942 0.00259 no no no no up up Serine+blood 16:0/14:0-PC+blood 0 0 0.522735043 serum_aminoacids serum_phospholipids 0.942 0.0206 no no no no up up Serine+blood 16:0/16:0-PC+blood 0 0 0.43042735 serum_aminoacids serum_phospholipids 0.942 0.00079 no no no no up up Serine+blood 16:0/16:0-PI+blood -0.583458647 0 0 serum_aminoacids serum_phospholipids 0.942 0.358 no no no no no no Serine+blood 16:0/16:1-PC+blood 0 -0.492647059 0 serum_aminoacids serum_phospholipids 0.942 0.00283 no no no up up no Serine+blood 16:0/16:1-PI+blood -0.657142857 -0.490196078 0 serum_aminoacids serum_phospholipids 0.942 0.262 no no no no no no Serine+blood 16:0/18:2-PC+blood 0 0.49754902 0.518632479 serum_aminoacids serum_phospholipids 0.942 3.24E-06 no no no no up up Serine+blood 16:0/18:2-PI+blood -0.658646617 0 0 serum_aminoacids serum_phospholipids 0.942 0.269 no no no no no no Serine+blood 16:0/20:4-PC+blood 0.479699248 0 0 serum_aminoacids serum_phospholipids 0.942 0.0262 no no no no up no Serine+blood 16:0/20:4-PI+blood -0.684210526 0 0 serum_aminoacids serum_phospholipids 0.942 0.558 no no no no no no Serine+blood 16:0/22:0-PE+blood 0 0 0.447521368 serum_aminoacids serum_phospholipids 0.942 0.00839 no no no dn no up Serine+blood 16:0/22:6-PC+blood 0 0 0.541196581 serum_aminoacids serum_phospholipids 0.942 4.53E-05 no no no no up up Serine+blood 16:1/16:0-PC+blood 0.45112782 0.730392157 0.536410256 serum_aminoacids serum_phospholipids 0.942 0.0215 no no no no up up Serine+blood 16:1/16:1-PC+blood 0 0.637254902 0 serum_aminoacids serum_phospholipids 0.942 0.0177 no no no no no up Serine+blood 18:0/16:0-PC+blood 0 0.534313725 0 serum_aminoacids serum_phospholipids 0.942 9.64E-07 no no no up up up Serine+blood 18:0/18:0-PC+blood 0 0 0.403760684 serum_aminoacids serum_phospholipids 0.942 0.426 no no no no no no Serine+blood 18:0/18:0-PE+blood -0.460150376 0 -0.545982906 serum_aminoacids serum_phospholipids 0.942 0.00896 no no no up up no Serine+blood 18:0/18:1-PE+blood -0.527819549 0 -0.48034188 serum_aminoacids serum_phospholipids 0.942 0.00716 no no no up up no Serine+blood 18:0/18:1-PG+blood 0 -0.50245098 -0.548717949 serum_aminoacids serum_phospholipids 0.942 0.000842 no no no no up no Serine+blood 18:0/18:2-PC+blood 0 0 0.502222222 serum_aminoacids serum_phospholipids 0.942 1.74E-06 no no no no up up Serine+blood 18:0/18:2-PI+blood -0.469172932 0 0 serum_aminoacids serum_phospholipids 0.942 0.179 no no no no no no Serine+blood 18:1/16:0-PC+blood 0 0.524509804 0.52957265 serum_aminoacids serum_phospholipids 0.942 2.43E-05 no no no no up up Serine+blood 18:1/16:0-PE+blood -0.44962406 0 -0.457094017 serum_aminoacids serum_phospholipids 0.942 0.000182 no no no up up no Serine+blood 18:1/16:0-PI+blood -0.57443609 0 0 serum_aminoacids serum_phospholipids 0.942 0.793 no no no no no no Serine+blood 18:1/18:0-PC+blood 0 0 0.497435897 serum_aminoacids serum_phospholipids 0.942 1.83E-06 no no no no up up Serine+blood 18:1/18:0-PE+blood 0 0 -0.500854701 serum_aminoacids serum_phospholipids 0.942 1.39E-06 no no no up up no Serine+blood 18:1/18:1-PE+blood 0 0 -0.461880342 serum_aminoacids serum_phospholipids 0.942 1.03E-05 no no no up up no Serine+blood 18:1/18:2-PE+blood 0 0 -0.509059829 serum_aminoacids serum_phospholipids 0.942 0.000293 no no no up up no Serine+blood 18:1/20:4-PC+blood 0.448120301 0.487745098 0 serum_aminoacids serum_phospholipids 0.942 0.582 no no no no no no Serine+blood 18:3/16:0-PE+blood -0.479699248 0 -0.421538462 serum_aminoacids serum_phospholipids 0.942 0.00149 no no no up up no Serine+blood 18:3n6+blood -0.571428571 -0.639705882 0 serum_aminoacids serum_fattyacid 0.942 0.0463 no no no up no dn Serine+blood 20:0/20:4-PE+blood 0 -0.595588235 -0.537777778 serum_aminoacids serum_phospholipids 0.942 0.00128 no no no up up no Serine+blood 20:1-LPC+blood 0 0 0.517948718 serum_aminoacids serum_phospholipids 0.942 0.217 no no no no no no Serine+blood 20:1/20:4-PE+blood 0 0 -0.522735043 serum_aminoacids serum_phospholipids 0.942 0.0042 no no no up up no Serine+blood 20:2/18:1-PE+blood -0.518796992 0 -0.433162393 serum_aminoacids serum_phospholipids 0.942 0.00208 no no no up up no Serine+blood 20:3/16:0-PC+blood 0.518796992 0 0 serum_aminoacids serum_phospholipids 0.942 0.00405 no no no no up up Serine+blood 20:3/18:0-PC+blood 0 0.585784314 0.55965812 serum_aminoacids serum_phospholipids 0.942 0.296 no no no no no no Serine+blood 20:3n6+blood -0.47518797 0 0 serum_aminoacids serum_fattyacid 0.942 0.0884 no no no up no no Serine+blood 20:4-LPA+blood 0 0.539215686 0 serum_aminoacids serum_phospholipids 0.942 0.398 no no no no no no Serine+blood 20:4/16:0-PE+blood 0 0 -0.517948718 serum_aminoacids serum_phospholipids 0.942 0.00529 no no no no up up Serine+blood 20:5/18:0-PC+blood 0 0.512254902 0.447521368 serum_aminoacids serum_phospholipids 0.942 3.97E-06 no no no no up up Serine+blood 24:1+blood 0.541353383 0 0.620512821 serum_aminoacids serum_fattyacid 0.942 0.00582 no no no no dn dn Serine+blood Acetic acid+stool 0 0.645454545 0 yes serum_aminoacids stool_scfa 0.942 0.0656 no no no dn no no Serine+blood Adipocytokine signaling pathway 0.492982456 0 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Alistipes 0 -0.484365511 0 serum_aminoacids Genus 0.942 0.0114 no no no no up no Serine+blood AMPK signaling pathway 0 -0.514705882 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Arginine and proline metabolism 0 0.532352941 0 serum_aminoacids kegg 0.942 NA no no no no up no Serine+blood Axon guidance 0 -0.520588235 0 serum_aminoacids kegg 0.942 NA no no no no up up Serine+blood B cell receptor signaling pathway 0.650877193 0 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Betaine+blood 0 0 0.526153846 serum_aminoacids serum_choline 0.942 0.857 no no no no no no Serine+blood Butyricimonas 0 -0.485077898 0 butyrate-producing serum_aminoacids Genus 0.942 0.17 no no no no no no Serine+blood CA+blood 0 -0.689147892 0 serum_aminoacids serum_bileacids 0.942 0.606 no no no no no no Serine+blood Central carbon metabolism in cancer -0.463157895 -0.714705882 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Choline+blood 0.551879699 0 0 serum_aminoacids serum_choline 0.942 0.0395 no no no no up no Serine+blood Colorectal cancer 0 -0.702941176 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Coronavirus disease - COVID-19 0 -0.517647059 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Creatinine+blood 0.642105263 0 0 serum_aminoacids serum_choline 0.942 0.437 no no no no no no Serine+blood Cysteine+blood 0 0 0.561025641 yes serum_aminoacids serum_aminoacids 0.942 1.81E-07 no no no dn up up Serine+blood Cystine+blood 0.661654135 0 0.638974359 yes serum_aminoacids serum_aminoacids 0.942 0.00028 no no no up up no Serine+blood Cytokine-cytokine receptor interaction 0 0.629411765 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood d18:1-14:0-SM+blood 0 -0.524509804 -0.438632479 serum_aminoacids serum_phospholipids 0.942 0.94 no no no no no no Serine+blood d18:1-14:1-SM+blood 0 0 -0.456410256 serum_aminoacids serum_phospholipids 0.942 0.0952 no no no no dn no Serine+blood DCA+stool 0 0 -0.77593985 serum_aminoacids stool_bileacids 0.942 0.195 no no no no no no Serine+blood DMG+blood 0.529323308 0 0 serum_aminoacids serum_choline 0.942 0.909 no no no no no no Serine+blood EGFR tyrosine kinase inhibitor resistance 0 -0.511764706 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Estrogen signaling pathway -0.587719298 0 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Fc epsilon RI signaling pathway 0.484210526 0 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood GCA+blood 0 -0.482843137 0 yes serum_aminoacids serum_bileacids 0.942 0.16 no no no no no no Serine+blood Glycine+blood 0.615037594 0.482843137 0.698461538 serum_aminoacids serum_aminoacids 0.942 0.00408 no no no dn no up Serine+blood Glycolysis / Gluconeogenesis -0.471929825 0 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood HCA+blood 0 -0.796684778 0 serum_aminoacids serum_bileacids 0.942 0.544 no no no no no no Serine+blood Inflammatory mediator regulation of TRP channels 0 -0.517647059 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood L-2-Aminobutyric acid+blood 0 0 0.503589744 yes serum_aminoacids serum_aminoacids 0.942 0.000328 no no no up up no Serine+blood L-Arginine+blood 0.648120301 0 0.637606838 serum_aminoacids serum_aminoacids 0.942 0.316 no no no no no no Serine+blood L-Asparagine+blood 0.645112782 0.534313725 0.64991453 serum_aminoacids serum_aminoacids 0.942 0.784 no no no no no no Serine+blood L-Aspartic acid+blood 0.485714286 0.507352941 0.422222222 yes serum_aminoacids serum_aminoacids 0.942 0.0226 no no no up up no Serine+blood L-Citrulline+blood 0.512781955 0 0 serum_aminoacids serum_aminoacids 0.942 0.534 no no no no no no Serine+blood L-Glutamine+blood 0.754887218 0 0.748376068 serum_aminoacids serum_aminoacids 0.942 0.639 no no no no no no Serine+blood L-Histidine+blood 0 0 0.641025641 serum_aminoacids serum_aminoacids 0.942 0.109 no no no no no no Serine+blood L-Lysine+blood 0.589473684 0 0.52957265 yes serum_aminoacids serum_aminoacids 0.942 0.0107 no no no no up no Serine+blood L-Ornithine+blood 0.476691729 0 0 serum_aminoacids serum_aminoacids 0.942 0.175 no no no no no no Serine+blood L-Phenylalanine+stool 0 0 0.562406015 serum_aminoacids stool_cometabolism 0.942 0.398 no no no no no no Serine+blood L-Threonine+blood 0.648120301 0.676470588 0 serum_aminoacids serum_aminoacids 0.942 0.0538 no no no dn no up Serine+blood L-Tryptophan+blood 0 0 0.534358974 serum_aminoacids serum_aminoacids 0.942 0.164 no no no no no no Serine+blood L-Tyrosine+stool 0 0 0.57593985 serum_aminoacids stool_cometabolism 0.942 0.44 no no no no no no Serine+blood lauric acid C12+blood 0.484210526 0 0 serum_aminoacids serum_mcfa 0.942 0.015 no no no no dn dn Serine+blood LCA+stool 0 0 -0.648120301 serum_aminoacids stool_bileacids 0.942 0.314 no no no no no no Serine+blood Legionellosis -0.666666667 0 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Lipid and atherosclerosis 0 0.544117647 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Longevity regulating pathway - multiple species -0.526315789 0 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Lysosome 0.6 0 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood mRNA surveillance pathway 0 -0.564705882 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood mTOR signaling pathway 0 -0.5 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood MUFA%+blood 0.578947368 0.644607843 0.604102564 serum_aminoacids serum_fattyacid 0.942 0.00142 no no no up no dn Serine+blood octanoic acid C8+blood 0 0 0.427692308 serum_aminoacids serum_mcfa 0.942 2.84E-11 no no no dn dn dn Serine+blood Olfactory transduction 0 0.605882353 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Pancreatic cancer 0 0 -0.606923077 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Primary immunodeficiency -0.656140351 0 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Propionic acid+stool 0 0 -0.621052632 yes serum_aminoacids stool_scfa 0.942 0.0436 no no no dn no up Serine+blood Proteoglycans in cancer 0 -0.505882353 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood PUFA/UFA+blood 0.643609023 0 0.632820513 serum_aminoacids serum_fattyacid 0.942 0.000732 no no no dn no up Serine+blood PUFA%+blood 0.711278195 0.504901961 0.591111111 serum_aminoacids serum_fattyacid 0.942 0.0013 no no no dn no up Serine+blood Ribosome 0 -0.517647059 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood RNA transport -0.631578947 -0.523529412 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Slackia 0 0 -0.437711631 serum_aminoacids Genus 0.942 0.94 no no no no no no Serine+blood Spinocerebellar ataxia 0 -0.626470588 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Th1 and Th2 cell differentiation 0.48245614 0 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Thermogenesis 0 -0.538235294 0 serum_aminoacids kegg 0.942 NA no no no no no no Serine+blood Yersinia infection 0 0.538235294 0 serum_aminoacids kegg 0.942 NA no no no no no no Serotonergic synapse 2-Oxocarboxylic acid metabolism 0 -0.416996047 -0.52046332 kegg kegg NA NA no no no no no no Serotonergic synapse ABC transporters 0 0 -0.400772201 kegg kegg NA NA no no no no up up Serotonergic synapse Aminoacyl-tRNA biosynthesis 0 0 -0.525353925 kegg kegg NA NA no no no no no no Serotonergic synapse Apelin signaling pathway 0 0 -0.515830116 kegg kegg NA NA no no no no no no Serotonergic synapse Apoptosis 0 0 0.412097812 kegg kegg NA NA no no no no no no Serotonergic synapse Arachidonic acid metabolism 0 0.646245059 0.583783784 kegg kegg NA NA no no no no no no Serotonergic synapse Ascorbate and aldarate metabolism 0 0 -0.714028314 kegg kegg NA NA no no no no no no Serotonergic synapse Autophagy - other 0 0 -0.544658945 kegg kegg NA NA no no no no no no Serotonergic synapse Bacteroides -0.413043478 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Serotonergic synapse Basal transcription factors 0 0 -0.731016731 kegg kegg NA NA no no no no no no Serotonergic synapse Base excision repair 0 0 -0.567824968 kegg kegg NA NA no no no no no no Serotonergic synapse Biosynthesis of cofactors 0 0 0.52972973 kegg kegg NA NA no no no no no no Serotonergic synapse Butanoate metabolism 0 0 -0.497554698 kegg kegg NA NA no no no no no no Serotonergic synapse cAMP signaling pathway 0 0 0.468983269 yes kegg kegg NA NA no no no no up up Serotonergic synapse Cell cycle 0 0 -0.577091377 kegg kegg NA NA no no no no no no Serotonergic synapse Chemokine signaling pathway 0 0 0.565250965 kegg kegg NA NA no no no no no no Serotonergic synapse Circadian entrainment 0.842608696 0.47826087 0.672586873 kegg kegg NA NA no no no no up up Serotonergic synapse Circadian rhythm 0 0 -0.571685972 kegg kegg NA NA no no no no no no Serotonergic synapse Citrate cycle (TCA cycle) 0 0 -0.709395109 kegg kegg NA NA no no no no no no Serotonergic synapse Complement and coagulation cascades 0 0 0.533590734 kegg kegg NA NA no no no no no no Serotonergic synapse Cysteine and methionine metabolism 0 0 -0.418275418 kegg kegg NA NA no no no no no no Serotonergic synapse DNA replication 0 0 -0.646332046 kegg kegg NA NA no no no no no no Serotonergic synapse EGFR tyrosine kinase inhibitor resistance -0.416521739 0 -0.467953668 kegg kegg NA NA no no no no no no Serotonergic synapse Endocrine resistance 0.412173913 0.511857708 0.508108108 kegg kegg NA NA no no no no no no Serotonergic synapse Ether lipid metabolism 0 0 -0.546975547 kegg kegg NA NA no no no no no no Serotonergic synapse Fanconi anemia pathway 0 0 -0.677734878 kegg kegg NA NA no no no no no no Serotonergic synapse Ferroptosis 0.549565217 0.508893281 0.445559846 kegg kegg NA NA no no no no no no Serotonergic synapse Folate biosynthesis 0 -0.500988142 0 kegg kegg NA NA no no no no no no Serotonergic synapse Galactose metabolism 0 0 -0.404375804 kegg kegg NA NA no no no no no no Serotonergic synapse Gap junction 0.600869565 0.77173913 0.831145431 kegg kegg NA NA no no no no no no Serotonergic synapse Glutamatergic synapse 0.657391304 0.735177866 0.756241956 kegg kegg NA NA no no no no up up Serotonergic synapse Glutathione metabolism 0 0 0.525096525 kegg kegg NA NA no no no no no no Serotonergic synapse Glycerolipid metabolism -0.480869565 0 -0.628571429 kegg kegg NA NA no no no no no up Serotonergic synapse Glycerophospholipid metabolism 0 0 -0.709395109 kegg kegg NA NA no no no no no up Serotonergic synapse "Glycine, serine and threonine metabolism" 0 0 0.574002574 kegg kegg NA NA no no no no up no Serotonergic synapse Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.553925354 kegg kegg NA NA no no no no no no Serotonergic synapse Glycosaminoglycan degradation 0 0 -0.472586873 kegg kegg NA NA no no no no no up Serotonergic synapse Glycosphingolipid biosynthesis - globo and isoglobo series 0.493043478 0 0 kegg kegg NA NA no no no no no no Serotonergic synapse Hedgehog signaling pathway 0 0 -0.597425997 kegg kegg NA NA no no no no no no Serotonergic synapse HIF-1 signaling pathway 0 0 -0.451994852 kegg kegg NA NA no no no no no no Serotonergic synapse Homologous recombination 0 0 -0.566023166 kegg kegg NA NA no no no no no no Serotonergic synapse Inositol phosphate metabolism 0 0 -0.644530245 kegg kegg NA NA no no no no no no Serotonergic synapse Intestinal immune network for IgA production 0 -0.433794466 0 kegg kegg NA NA no no no no no no Serotonergic synapse Lysine degradation -0.531304348 0 -0.682368082 kegg kegg NA NA no no no no no no Serotonergic synapse Mannose type O-glycan biosynthesis -0.429565217 0 -0.603861004 kegg kegg NA NA no no no no no no Serotonergic synapse mRNA surveillance pathway 0 0 -0.552123552 kegg kegg NA NA no no no no no no Serotonergic synapse mTOR signaling pathway 0 0 -0.487001287 kegg kegg NA NA no no no no no no Serotonergic synapse N-Glycan biosynthesis 0 0 -0.577091377 kegg kegg NA NA no no no no no no Serotonergic synapse Necroptosis 0.431304348 0 0.436808237 kegg kegg NA NA no no no no no no Serotonergic synapse Neutrophil extracellular trap formation 0 0 0.514285714 kegg kegg NA NA no no no no no no Serotonergic synapse NF-kappa B signaling pathway -0.592173913 0 0 kegg kegg NA NA no no no no no no Serotonergic synapse Nitrogen metabolism 0 0 0.471299871 kegg kegg NA NA no no no no no no Serotonergic synapse Notch signaling pathway 0 0 -0.578378378 kegg kegg NA NA no no no no no no Serotonergic synapse Nucleotide excision repair 0 0 -0.534362934 kegg kegg NA NA no no no no no no Serotonergic synapse Odoribacter 0 -0.475979667 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Serotonergic synapse One carbon pool by folate 0 0 -0.664607465 kegg kegg NA NA no no no no no no Serotonergic synapse Oocyte meiosis 0 -0.421936759 0 kegg kegg NA NA no no no no no no Serotonergic synapse Other glycan degradation 0 0 -0.564993565 kegg kegg NA NA no no no no no no Serotonergic synapse Other types of O-glycan biosynthesis 0 0 -0.676705277 kegg kegg NA NA no no no no no no Serotonergic synapse p53 signaling pathway 0 0 -0.449163449 kegg kegg NA NA no no no no no no Serotonergic synapse Pentose and glucuronate interconversions 0 0 -0.538996139 kegg kegg NA NA no no no no no no Serotonergic synapse Phagosome 0 0 0.401029601 kegg kegg NA NA no no no no no no Serotonergic synapse Phosphatidylinositol signaling system 0 0 -0.597683398 kegg kegg NA NA no no no no no no Serotonergic synapse Phospholipase D signaling pathway 0 0.491106719 0.508880309 kegg kegg NA NA no no no no up up Serotonergic synapse PI3K-Akt signaling pathway 0 0 -0.542599743 yes kegg kegg NA NA no no no no up up Serotonergic synapse Platelet activation 0.522608696 0 0.534362934 kegg kegg NA NA no no no no no no Serotonergic synapse Platinum drug resistance 0 0 -0.461261261 kegg kegg NA NA no no no no no no Serotonergic synapse Porphyrin and chlorophyll metabolism 0 0 0.531016731 kegg kegg NA NA no no no no no no Serotonergic synapse Propanoate metabolism 0 0 -0.421621622 kegg kegg NA NA no no no no no no Serotonergic synapse Proteasome 0 -0.610671937 -0.462290862 kegg kegg NA NA no no no no no no Serotonergic synapse Protein export 0 -0.423913043 -0.544401544 kegg kegg NA NA no no no no no no Serotonergic synapse Rap1 signaling pathway 0 0 0.519433719 kegg kegg NA NA no no no no no no Serotonergic synapse Retinol metabolism 0 0 -0.636036036 kegg kegg NA NA no no no no no no Serotonergic synapse Ribosome biogenesis in eukaryotes 0 0 -0.762676963 kegg kegg NA NA no no no no no no Serotonergic synapse RNA degradation 0 0 -0.727670528 kegg kegg NA NA no no no no no no Serotonergic synapse RNA polymerase 0 0 -0.717889318 kegg kegg NA NA no no no no no no Serotonergic synapse RNA transport 0 -0.431818182 0 kegg kegg NA NA no no no no no no Serotonergic synapse Ruminococcus 0 -0.502964427 0 acetate-producing kegg Genus NA 0.335 no no no no no no Serotonergic synapse Selenocompound metabolism 0 0 -0.712226512 kegg kegg NA NA no no no no no no Serotonergic synapse Signaling pathways regulating pluripotency of stem cells 0 0 -0.408236808 kegg kegg NA NA no no no no no no Serotonergic synapse Spliceosome 0 0 -0.615701416 kegg kegg NA NA no no no no no no Serotonergic synapse Steroid biosynthesis 0 0 -0.439382239 kegg kegg NA NA no no no no no no Serotonergic synapse Steroid hormone biosynthesis 0 0 -0.475675676 kegg kegg NA NA no no no no no no Serotonergic synapse Sulfur metabolism 0 0 0.473359073 kegg kegg NA NA no no no no no no Serotonergic synapse Synthesis and degradation of ketone bodies 0 0 -0.505534106 kegg kegg NA NA no no no no no no Serotonergic synapse Taurine and hypotaurine metabolism 0 0 -0.452767053 kegg kegg NA NA no no no no no no Serotonergic synapse Terpenoid backbone biosynthesis 0 -0.424901186 -0.687258687 kegg kegg NA NA no no no no no no Serotonergic synapse Th17 cell differentiation -0.415652174 -0.469367589 -0.404118404 kegg kegg NA NA no no no no no no Serotonergic synapse Tryptophan metabolism 0 0 -0.604890605 kegg kegg NA NA no no no no up no Serotonergic synapse Ubiquinone and other terpenoid-quinone biosynthesis 0 0 -0.54002574 kegg kegg NA NA no no no no no no Serotonergic synapse "Valine, leucine and isoleucine degradation" 0 0 -0.61003861 kegg kegg NA NA no no no no no no Serotonergic synapse Various types of N-glycan biosynthesis 0 -0.471343874 -0.624195624 kegg kegg NA NA no no no no no no Serotonergic synapse Vascular smooth muscle contraction 0 0 0.511454311 kegg kegg NA NA no no no no no no Serotonergic synapse Viral protein interaction with cytokine and cytokine receptor 0 0.515810277 0.481081081 kegg kegg NA NA no no no no no no Serotonergic synapse Wnt signaling pathway 0 0 -0.563191763 kegg kegg NA NA no no no no no no SFA%+blood 14:0/20:4-PC+blood 0 0 -0.437264957 serum_fattyacid serum_phospholipids 0.0236 0.486 no up no no no no SFA%+blood 16:0/14:0-PC+blood 0.494736842 0 0 serum_fattyacid serum_phospholipids 0.0236 0.0206 no up no no up up SFA%+blood 16:0/16:0-PC+blood 0.476691729 0 0 serum_fattyacid serum_phospholipids 0.0236 0.00079 no up no no up up SFA%+blood 16:0/16:0-PI+blood -0.472180451 0 0 serum_fattyacid serum_phospholipids 0.0236 0.358 no up no no no no SFA%+blood 16:0/16:1-PI+blood -0.521804511 0 0 serum_fattyacid serum_phospholipids 0.0236 0.262 no up no no no no SFA%+blood 16:0/18:1-PC+blood 0.667669173 0 0.407179487 serum_fattyacid serum_phospholipids 0.0236 6.15E-07 no up no up up up SFA%+blood 16:0/18:2-PC+blood 0.687218045 0.610294118 0.519316239 serum_fattyacid serum_phospholipids 0.0236 3.24E-06 no up no no up up SFA%+blood 16:0/18:2-PI+blood -0.464661654 0 0 serum_fattyacid serum_phospholipids 0.0236 0.269 no up no no no no SFA%+blood 16:0/20:3-PC+blood 0.518796992 0 0.442735043 serum_fattyacid serum_phospholipids 0.0236 5.43E-06 no up no no up up SFA%+blood 16:0/20:4-PC+blood 0.502255639 0 0 serum_fattyacid serum_phospholipids 0.0236 0.0262 no up no no up no SFA%+blood 16:0/20:4-PI+blood -0.593984962 0 0 serum_fattyacid serum_phospholipids 0.0236 0.558 no up no no no no SFA%+blood 16:0/22:6-PC+blood 0 0 0.489230769 serum_fattyacid serum_phospholipids 0.0236 4.53E-05 no up no no up up SFA%+blood 16:1/16:0-PC+blood 0.609022556 0 0 serum_fattyacid serum_phospholipids 0.0236 0.0215 no up no no up up SFA%+blood 18:0-LPA+blood 0 0.659313725 0 serum_fattyacid serum_phospholipids 0.0236 0.0725 no up no no dn no SFA%+blood 18:0-LPE+blood 0 0 -0.484444444 serum_fattyacid serum_phospholipids 0.0236 0.491 no up no no no no SFA%+blood 18:0/16:0-PC+blood 0.661654135 0 0 serum_fattyacid serum_phospholipids 0.0236 9.64E-07 no up no up up up SFA%+blood 18:0/18:0-PE+blood -0.544360902 0 -0.481709402 serum_fattyacid serum_phospholipids 0.0236 0.00896 no up no up up no SFA%+blood 18:0/18:1-PE+blood -0.563909774 0 -0.435213675 serum_fattyacid serum_phospholipids 0.0236 0.00716 no up no up up no SFA%+blood 18:0/18:1-PG+blood 0 0 -0.466666667 serum_fattyacid serum_phospholipids 0.0236 0.000842 no up no no up no SFA%+blood 18:0/18:2-PC+blood 0.562406015 0 0.441367521 serum_fattyacid serum_phospholipids 0.0236 1.74E-06 no up no no up up SFA%+blood 18:0/20:4-PC+blood 0.448120301 0 0 serum_fattyacid serum_phospholipids 0.0236 0.454 no up no no no no SFA%+blood 18:1/16:0-PC+blood 0.696240602 0.598039216 0.513846154 serum_fattyacid serum_phospholipids 0.0236 2.43E-05 no up no no up up SFA%+blood 18:1/16:0-PE+blood 0 0 -0.418803419 serum_fattyacid serum_phospholipids 0.0236 0.000182 no up no up up no SFA%+blood 18:1/16:0-PI+blood -0.458646617 0 0 serum_fattyacid serum_phospholipids 0.0236 0.793 no up no no no no SFA%+blood 18:1/18:0-PC+blood 0.601503759 0 0.44 serum_fattyacid serum_phospholipids 0.0236 1.83E-06 no up no no up up SFA%+blood 18:1/18:0-PI+blood -0.520300752 -0.507352941 0 serum_fattyacid serum_phospholipids 0.0236 0.0931 no up no no no up SFA%+blood 18:1/18:1-PC+blood 0.488721805 0 0.464615385 serum_fattyacid serum_phospholipids 0.0236 1.34E-05 no up no no up up SFA%+blood 18:1/18:2-PE+blood 0 0 -0.461880342 serum_fattyacid serum_phospholipids 0.0236 0.000293 no up no up up no SFA%+blood 18:1/20:4-PE+blood 0 0 -0.487179487 serum_fattyacid serum_phospholipids 0.0236 0.0578 no up no up no no SFA%+blood 18:2-LPA+blood 0 0.531862745 0 serum_fattyacid serum_phospholipids 0.0236 0.00684 no up no dn no up SFA%+blood 18:2/16:0-PC+blood 0.610526316 0 0 serum_fattyacid serum_phospholipids 0.0236 8.67E-05 no up no no up up SFA%+blood 18:3n6+blood -0.512781955 0 0 serum_fattyacid serum_fattyacid 0.0236 0.0463 no up no up no dn SFA%+blood 20:0/20:4-PE+blood 0 0 -0.50017094 serum_fattyacid serum_phospholipids 0.0236 0.00128 no up no up up no SFA%+blood 20:1-LPA+blood 0 0.585784314 0 serum_fattyacid serum_phospholipids 0.0236 0.0187 no up no dn dn no SFA%+blood 20:1/20:4-PE+blood 0 0 -0.478974359 serum_fattyacid serum_phospholipids 0.0236 0.0042 no up no up up no SFA%+blood 20:2/18:1-PE+blood -0.517293233 0 0 serum_fattyacid serum_phospholipids 0.0236 0.00208 no up no up up no SFA%+blood 20:3/16:0-PC+blood 0.536842105 0 0 serum_fattyacid serum_phospholipids 0.0236 0.00405 no up no no up up SFA%+blood 20:4-LPA+blood 0 0.566176471 0 serum_fattyacid serum_phospholipids 0.0236 0.398 no up no no no no SFA%+blood 20:4/16:0-PE+blood -0.520300752 0 -0.499487179 serum_fattyacid serum_phospholipids 0.0236 0.00529 no up no no up up SFA%+blood 20:5/18:0-PC+blood 0 0 0.489230769 serum_fattyacid serum_phospholipids 0.0236 3.97E-06 no up no no up up SFA%+blood 22:1-LPA+blood 0 0.602941176 0 serum_fattyacid serum_phospholipids 0.0236 0.00373 no up no no up up SFA%+blood 22:2-LPA+blood 0 0.544117647 0 serum_fattyacid serum_phospholipids 0.0236 0.0443 no up no dn no no SFA%+blood 24:1+blood 0 0 0.48034188 serum_fattyacid serum_fattyacid 0.0236 0.00582 no up no no dn dn SFA%+blood 4-hydroxybenzoic acid+stool 0 0 0.461654135 serum_fattyacid stool_cometabolism 0.0236 0.0536 no up no no dn no SFA%+blood Adrenergic signaling in cardiomyocytes 0 -0.655882353 0 serum_fattyacid kegg 0.0236 NA no up no no no up SFA%+blood AGE-RAGE signaling pathway in diabetic complications 0 0.567647059 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Aldosterone synthesis and secretion 0 -0.661764706 0 serum_fattyacid kegg 0.0236 NA no up no no up up SFA%+blood Alistipes 0.481512862 0 0 serum_fattyacid Genus 0.0236 0.0114 no up no no up no SFA%+blood Allograft rejection 0 0.582352941 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Alzheimer disease 0 -0.555882353 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Amoebiasis 0 0.561764706 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Amphetamine addiction 0 -0.708823529 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Amyotrophic lateral sclerosis 0 -0.570588235 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Apelin signaling pathway 0 -0.632352941 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Apoptosis 0 0.585294118 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Autoimmune thyroid disease 0 0.582352941 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood B cell receptor signaling pathway 0 0.514705882 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Biosynthesis of amino acids 0 0.691176471 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Bladder cancer 0 0.564705882 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Breast cancer 0 0 -0.503076923 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood C-type lectin receptor signaling pathway 0 0.526470588 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood CA+blood 0 -0.507664105 0 serum_fattyacid serum_bileacids 0.0236 0.606 no up no no no no SFA%+blood Cardiac muscle contraction 0 -0.523529412 0 serum_fattyacid kegg 0.0236 NA no up no no no up SFA%+blood CDCA+blood 0 -0.56127451 0 serum_fattyacid serum_bileacids 0.0236 0.506 no up no no no no SFA%+blood Cell adhesion molecules 0 0.623529412 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Cell cycle 0 -0.679411765 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Cellular senescence 0 0.644117647 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood cGMP-PKG signaling pathway 0 0.538235294 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Chemical carcinogenesis - receptor activation 0 -0.532352941 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Chemokine signaling pathway 0 0.544117647 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Choline+blood 0.488721805 0 0 serum_fattyacid serum_choline 0.0236 0.0395 no up no no up no SFA%+blood Colorectal cancer 0 0 -0.443846154 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Coronavirus disease - COVID-19 0 -0.591176471 0.483846154 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Creatinine+blood 0 0.522058824 0.571965812 serum_fattyacid serum_choline 0.0236 0.437 no up no no no no SFA%+blood Cushing syndrome 0 -0.564705882 0 serum_fattyacid kegg 0.0236 NA no up no no no up SFA%+blood Cysteine+blood 0 0.644607843 0.512478632 yes serum_fattyacid serum_aminoacids 0.0236 1.81E-07 no up no dn up up SFA%+blood Cystine+blood 0 0.723039216 0.545299145 yes serum_fattyacid serum_aminoacids 0.0236 0.00028 no up no up up no SFA%+blood Cytosolic DNA-sensing pathway 0.538596491 0 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood d18:1-16:1-SM+blood 0 0 -0.442735043 serum_fattyacid serum_phospholipids 0.0236 0.2 no up no no no no SFA%+blood d18:1-18:0-SM+blood 0.536842105 0 0 serum_fattyacid serum_phospholipids 0.0236 0.97 no up no no no no SFA%+blood DCA+stool 0 0 -0.514285714 serum_fattyacid stool_bileacids 0.0236 0.195 no up no no no no SFA%+blood Diabetic cardiomyopathy 0 -0.541176471 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood DMG+blood 0 0 0.439316239 serum_fattyacid serum_choline 0.0236 0.909 no up no no no no SFA%+blood Dopaminergic synapse 0 -0.602941176 0 serum_fattyacid kegg 0.0236 NA no up no no up no SFA%+blood DPA+blood 0 0.490196078 0 serum_fattyacid serum_ARA 0.0236 0.519 no up no no no no SFA%+blood EGFR tyrosine kinase inhibitor resistance 0 -0.635294118 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Endocrine resistance 0 0 -0.530769231 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Endocytosis 0 0.667647059 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Epithelial cell signaling in Helicobacter pylori infection 0 0.65 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood ErbB signaling pathway 0 0 -0.41 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Estrogen signaling pathway 0 -0.541176471 -0.437692308 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Ethanolamine+blood 0 0.629901961 0 serum_fattyacid serum_aminoacids 0.0236 0.122 no up no up no no SFA%+blood Fc epsilon RI signaling pathway 0 0.535294118 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Fc gamma R-mediated phagocytosis 0 0.594117647 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Fusobacterium 0 0 0.446866005 serum_fattyacid Genus 0.0236 0.628 no up no no no no SFA%+blood Gap junction 0 0 -0.446923077 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Glucagon signaling pathway 0 -0.638235294 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Glycine+blood 0.545864662 0.696078431 0.550769231 serum_fattyacid serum_aminoacids 0.0236 0.00408 no up no dn no up SFA%+blood Graft-versus-host disease 0 0.582352941 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood "Growth hormone synthesis, secretion and action" 0 0 -0.584615385 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood HDCA+blood 0.518101712 0 0 serum_fattyacid serum_bileacids 0.0236 0.483 no up no no no no SFA%+blood heptanoic acid C7+blood 0 0.5 0.494017094 serum_fattyacid serum_mcfa 0.0236 8.27E-11 no up no dn dn no SFA%+blood HIF-1 signaling pathway 0 -0.5 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Human papillomavirus infection 0 0.6 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Huntington disease 0 -0.523529412 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood IL-17 signaling pathway 0 0.626470588 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Inflammatory mediator regulation of TRP channels 0 -0.564705882 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Influenza A 0 0.502941176 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Insulin signaling pathway 0 -0.626470588 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood iso-DCA+blood 0.47518797 0 0 serum_fattyacid serum_bileacids 0.0236 0.38 no up no no no no SFA%+blood L-Arginine+blood 0 0.529411765 0.490598291 serum_fattyacid serum_aminoacids 0.0236 0.316 no up no no no no SFA%+blood L-Asparagine+blood 0 0.531862745 0.635555556 serum_fattyacid serum_aminoacids 0.0236 0.784 no up no no no no SFA%+blood L-Aspartic acid+blood 0.590977444 0 0 yes serum_fattyacid serum_aminoacids 0.0236 0.0226 no up no up up no SFA%+blood L-Glutamic acid+blood 0 0.485294118 0 yes serum_fattyacid serum_aminoacids 0.0236 6.20E-05 no up no up up no SFA%+blood L-Glutamine+blood 0.491729323 0 0.632136752 serum_fattyacid serum_aminoacids 0.0236 0.639 no up no no no no SFA%+blood L-Histidine+blood 0.523308271 0 0.558974359 serum_fattyacid serum_aminoacids 0.0236 0.109 no up no no no no SFA%+blood L-Isoleucine+blood 0 0.5 0.468034188 yes serum_fattyacid serum_aminoacids 0.0236 5.47E-06 no up no up up no SFA%+blood L-Leucine+blood 0 0 0.47965812 yes serum_fattyacid serum_aminoacids 0.0236 3.22E-05 no up no up up no SFA%+blood L-Lysine+blood 0 0.620098039 0.409230769 yes serum_fattyacid serum_aminoacids 0.0236 0.0107 no up no no up no SFA%+blood L-Methionine+blood 0 0.556372549 0 serum_fattyacid serum_aminoacids 0.0236 0.626 no up no no no no SFA%+blood L-Phenylalanine+blood 0 0.632352941 0.406495726 yes serum_fattyacid serum_aminoacids 0.0236 0.0103 no up no up up no SFA%+blood L-Tryptophan+blood 0 0.536764706 0.482393162 serum_fattyacid serum_aminoacids 0.0236 0.164 no up no no no no SFA%+blood LCA+stool 0 0 -0.460150376 serum_fattyacid stool_bileacids 0.0236 0.314 no up no no no no SFA%+blood Lipid and atherosclerosis 0 0.782352941 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Long-term depression 0 0 -0.421538462 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Long-term potentiation 0 -0.597058824 0 serum_fattyacid kegg 0.0236 NA no up no no no up SFA%+blood Longevity regulating pathway - multiple species -0.612280702 0 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Lysosome 0 0.535294118 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood mRNA surveillance pathway 0 -0.685294118 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood mTOR signaling pathway 0 -0.638235294 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood MUFA%+blood 0.610526316 0.784313725 0.656752137 serum_fattyacid serum_fattyacid 0.0236 0.00142 no up no up no dn SFA%+blood Natural killer cell mediated cytotoxicity 0 0.620588235 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Neuroactive ligand-receptor interaction 0 0.611764706 0 serum_fattyacid kegg 0.0236 NA no up no up up up SFA%+blood Neutrophil extracellular trap formation 0 0.561764706 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood NF-kappa B signaling pathway 0 0.544117647 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Nicotinate and nicotinamide metabolism 0 0.55 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood NOD-like receptor signaling pathway 0 0.614705882 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood octanoic acid C8+blood 0 0 0.582905983 serum_fattyacid serum_mcfa 0.0236 2.84E-11 no up no dn dn dn SFA%+blood Olfactory transduction 0 0.520588235 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Osteoclast differentiation 0 0.579411765 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Oxidative phosphorylation 0 -0.514705882 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Pancreatic cancer 0 0 -0.416923077 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood "Parathyroid hormone synthesis, secretion and action" 0 -0.544117647 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Pathogenic Escherichia coli infection 0 0.561764706 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Pathways in cancer 0 0 -0.419230769 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Peroxisome 0 0.641176471 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Pertussis 0 0.708823529 0 serum_fattyacid kegg 0.0236 NA no up no no no dn SFA%+blood Phagosome 0 0.591176471 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Phospholipase D signaling pathway 0 0 -0.485384615 serum_fattyacid kegg 0.0236 NA no up no no up up SFA%+blood PPAR signaling pathway 0 0.5 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Prevotella -0.496454894 0 0 acetate-producing serum_fattyacid Genus 0.0236 0.287 no up no no no no SFA%+blood Prion disease 0 -0.632352941 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Prolactin signaling pathway 0 0.520588235 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Proteasome 0 0 0.74 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Protein processing in endoplasmic reticulum 0 -0.7 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Proteoglycans in cancer 0 -0.552941176 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood PUFA/MUFA+blood 0.718796992 0.617647059 0.472136752 serum_fattyacid serum_fattyacid 0.0236 0.00108 no up no dn no up SFA%+blood PUFA/UFA+blood 0.969924812 0.909313725 0.868034188 serum_fattyacid serum_fattyacid 0.0236 0.000732 no up no dn no up SFA%+blood PUFA%+blood 0.929323308 0.892156863 0.738119658 serum_fattyacid serum_fattyacid 0.0236 0.0013 no up no dn no up SFA%+blood Ras signaling pathway 0 -0.614705882 0 yes serum_fattyacid kegg 0.0236 NA no up no no up up SFA%+blood Relaxin signaling pathway 0.466666667 0 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Retrograde endocannabinoid signaling 0 -0.629411765 0 serum_fattyacid kegg 0.0236 NA no up no no no up SFA%+blood Rheumatoid arthritis 0 0.65 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Ribosome 0 -0.591176471 0.483846154 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Ribosome biogenesis in eukaryotes 0 -0.576470588 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood RIG-I-like receptor signaling pathway 0 0.523529412 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood RNA degradation 0 -0.623529412 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood RNA transport 0 -0.576470588 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Ruminococcus 0 0 -0.433817569 serum_fattyacid Genus 0.0236 0.0679 no up no no no dn SFA%+blood Serine+blood 0.62556391 0 0.667692308 serum_fattyacid serum_aminoacids 0.0236 0.942 no up no no no no SFA%+blood Spinocerebellar ataxia 0 -0.55 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Staphylococcus aureus infection 0 0.555882353 0 serum_fattyacid kegg 0.0236 NA no up no up no no SFA%+blood Systemic lupus erythematosus 0 0.555882353 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood TCA+stool -0.800550964 0 0 serum_fattyacid stool_bileacids 0.0236 0.458 no up no no no no SFA%+blood Thermogenesis 0 -0.588235294 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Toll-like receptor signaling pathway 0 0.591176471 0 yes serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Toxoplasmosis 0 0.541176471 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Transcriptional misregulation in cancer 0 0 -0.467692308 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Tuberculosis 0 0.585294118 0 serum_fattyacid kegg 0.0236 NA no up no no no dn SFA%+blood Type I diabetes mellitus 0 0.582352941 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Viral carcinogenesis 0 0.623529412 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Viral myocarditis 0 0.517647059 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Wnt signaling pathway 0 -0.679411765 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA%+blood Yersinia infection 0 0.573529412 0 serum_fattyacid kegg 0.0236 NA no up no no no no SFA+blood 11-HETE+blood 0 0.516219364 0 serum_fattyacid serum_ARA 0.0386 0.464 up no no no no no SFA+blood 12-HEPE+blood -0.486204163 0 0 serum_fattyacid serum_ARA 0.0386 0.312 up no no no no no SFA+blood 14:0-LPC+blood 0 0 0.48991453 serum_fattyacid serum_phospholipids 0.0386 0.00689 up no no up up no SFA+blood 14:0/16:0-PC+blood 0 0 0.571965812 serum_fattyacid serum_phospholipids 0.0386 0.0358 up no no no up no SFA+blood 14:0/18:0-PC+blood 0 0 0.575384615 serum_fattyacid serum_phospholipids 0.0386 0.00289 up no no up up no SFA+blood 14:0/18:2-PC+blood 0 0 0.418119658 serum_fattyacid serum_phospholipids 0.0386 0.102 up no no no up no SFA+blood 14:0+blood 0.763909774 0.549019608 0.63008547 yes serum_fattyacid serum_fattyacid 0.0386 0.00572 up no no up no dn SFA+blood 16:0/16:0-PI+blood 0 0 0.424273504 serum_fattyacid serum_phospholipids 0.0386 0.358 up no no no no no SFA+blood 16:0/16:1-PC+blood 0 0 0.595897436 serum_fattyacid serum_phospholipids 0.0386 0.00283 up no no up up no SFA+blood 16:0/16:1-PI+blood 0 0 0.496068376 serum_fattyacid serum_phospholipids 0.0386 0.262 up no no no no no SFA+blood 16:0/18:0-PS+blood 0 0.536764706 0 serum_fattyacid serum_phospholipids 0.0386 0.377 up no no no no no SFA+blood 16:0/18:1-PC+blood 0 0 0.524102564 serum_fattyacid serum_phospholipids 0.0386 6.15E-07 up no no up up up SFA+blood 16:0/18:2-PI+blood 0 0 0.433846154 serum_fattyacid serum_phospholipids 0.0386 0.269 up no no no no no SFA+blood 16:0/18:3-PC+blood 0 0 0.429059829 serum_fattyacid serum_phospholipids 0.0386 0.00216 up no no no up up SFA+blood 16:0/20:4-PI+blood 0 0 0.459145299 serum_fattyacid serum_phospholipids 0.0386 0.558 up no no no no no SFA+blood 16:0+blood 0.97443609 0.894607843 0.95965812 yes serum_fattyacid serum_fattyacid 0.0386 0.00876 up no no up no no SFA+blood 16:1-LPC+blood 0 0 0.647179487 serum_fattyacid serum_phospholipids 0.0386 0.0241 up no no no up no SFA+blood 16:1/18:2-PG+blood 0 0.556372549 0 serum_fattyacid serum_phospholipids 0.0386 1.40E-08 up no no no up up SFA+blood 16:1+blood 0.631578947 0.519607843 0.564444444 yes serum_fattyacid serum_fattyacid 0.0386 0.0186 up no no no no dn SFA+blood 18:0/16:0-PC+blood 0 0 0.48991453 serum_fattyacid serum_phospholipids 0.0386 9.64E-07 up no no up up up SFA+blood 18:0/20:4-PI+blood 0 0.526960784 0 serum_fattyacid serum_phospholipids 0.0386 0.167 up no no no no no SFA+blood 18:0+blood 0.801503759 0.762254902 0.578119658 serum_fattyacid serum_fattyacid 0.0386 0.344 up no no no no no SFA+blood 18:1-LPE+blood 0 0 -0.423589744 serum_fattyacid serum_phospholipids 0.0386 0.117 up no no no no no SFA+blood 18:1/18:0-PS+blood 0 0.671568627 0 serum_fattyacid serum_phospholipids 0.0386 0.193 up no no no no no SFA+blood 18:1+blood 0.72481203 0.580882353 0.518632479 yes serum_fattyacid serum_fattyacid 0.0386 0.00202 up no no up no dn SFA+blood 18:2-LPC+blood 0 0 -0.487179487 serum_fattyacid serum_phospholipids 0.0386 0.00743 up no no dn no up SFA+blood 18:2/18:2-PS+blood 0 0.482843137 0 serum_fattyacid serum_phospholipids 0.0386 0.00674 up no no up up no SFA+blood 18:2n6c+blood 0.661654135 0.647058824 0.608205128 serum_fattyacid serum_fattyacid 0.0386 0.15 up no no no no no SFA+blood 18:3n3+blood 0.455639098 0 0 serum_fattyacid serum_fattyacid 0.0386 0.291 up no no no no no SFA+blood 20:2/18:3-PE+blood 0 0.539215686 0 serum_fattyacid serum_phospholipids 0.0386 0.0391 up no no up up no SFA+blood 20:3-LPE+blood 0.479699248 0 0 serum_fattyacid serum_phospholipids 0.0386 0.084 up no no no up no SFA+blood 20:3n6+blood 0.448120301 0 0.612991453 serum_fattyacid serum_fattyacid 0.0386 0.0884 up no no up no no SFA+blood 20:4-LPA+blood 0.527819549 0 0 serum_fattyacid serum_phospholipids 0.0386 0.398 up no no no no no SFA+blood 20:4/18:0-PE+blood 0 0.482843137 0 serum_fattyacid serum_phospholipids 0.0386 0.000755 up no no up up no SFA+blood 22:6n3+blood 0.493233083 0 0 serum_fattyacid serum_fattyacid 0.0386 0.792 up no no no no no SFA+blood 24:0+blood 0 0.56127451 0 serum_fattyacid serum_fattyacid 0.0386 0.034 up no no dn no up SFA+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0.664835165 0 0 serum_fattyacid stool_cometabolism 0.0386 0.33 up no no no no no SFA+blood AA+blood 0.463157895 0 0 serum_fattyacid serum_ARA 0.0386 0.212 up no no no no no SFA+blood Acetic acid+stool 0 -0.645454545 0 yes serum_fattyacid stool_scfa 0.0386 0.0656 up no no dn no no SFA+blood Adherens junction 0 0 -0.495384615 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Arginine and proline metabolism 0 0 0.452307692 serum_fattyacid kegg 0.0386 NA up no no no up no SFA+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.542307692 serum_fattyacid kegg 0.0386 NA up no no no up up SFA+blood Bacterial invasion of epithelial cells 0 0 -0.556153846 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Betaine+blood 0 0 -0.475555556 serum_fattyacid serum_choline 0.0386 0.857 up no no no no no SFA+blood Bifidobacterium 0 -0.521152765 0 acetate-producing serum_fattyacid Genus 0.0386 0.105 up no no no dn no SFA+blood Central carbon metabolism in cancer 0.589473684 0 0 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Cytosolic DNA-sensing pathway -0.484210526 0 0 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood DCA+blood -0.469172932 0 0 serum_fattyacid serum_bileacids 0.0386 0.122 up no no no no no SFA+blood DHA+blood 0.457142857 0 0 serum_fattyacid serum_ARA 0.0386 0.872 up no no no no no SFA+blood Dilated cardiomyopathy 0 0 -0.460769231 serum_fattyacid kegg 0.0386 NA up no no no up up SFA+blood DPA+blood 0.482706767 0 0 serum_fattyacid serum_ARA 0.0386 0.519 up no no no no no SFA+blood EGFR tyrosine kinase inhibitor resistance 0 0 0.413846154 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Focal adhesion 0 0 -0.588461538 serum_fattyacid kegg 0.0386 NA up no no no up up SFA+blood FoxO signaling pathway 0 0 -0.452307692 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Gastric acid secretion 0 0 -0.434615385 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood GCDCA+blood 0 0 -0.455042735 serum_fattyacid serum_bileacids 0.0386 0.31 up no no no no no SFA+blood GLCA+blood 0 -0.525105032 -0.462609563 serum_fattyacid serum_bileacids 0.0386 0.319 up no no no no no SFA+blood "Glycine, serine and threonine metabolism" 0 -0.679411765 0 serum_fattyacid kegg 0.0386 NA up no no no up no SFA+blood Hepatocellular carcinoma 0 0 -0.439230769 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Hippo signaling pathway 0 0 -0.57 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Hypertrophic cardiomyopathy 0 0 -0.545384615 serum_fattyacid kegg 0.0386 NA up no no no up up SFA+blood iso-heptanoic acid C7+blood 0 0 0.432478632 serum_fattyacid serum_mcfa 0.0386 0.00256 up no no up up no SFA+blood Kaposi sarcoma-associated herpesvirus infection -0.496491228 0 0 serum_fattyacid kegg 0.0386 NA up no no no no dn SFA+blood L-Phenylalanine+stool 0 -0.636363636 0 serum_fattyacid stool_cometabolism 0.0386 0.398 up no no no no no SFA+blood L-Proline+blood 0 0 -0.416752137 yes serum_fattyacid serum_aminoacids 0.0386 0.00265 up no no up up no SFA+blood L-Threonine+blood 0 -0.485294118 0 serum_fattyacid serum_aminoacids 0.0386 0.0538 up no no dn no up SFA+blood Leukocyte transendothelial migration 0 0 -0.523076923 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Longevity regulating pathway - multiple species 0.466666667 0 0 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood mTOR signaling pathway 0 0 0.450769231 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood MUFA+blood 0.717293233 0.62745098 0.535042735 serum_fattyacid serum_fattyacid 0.0386 0.00175 up no no up no dn SFA+blood n6+blood 0.827067669 0.867647059 0.765470085 serum_fattyacid serum_fattyacid 0.0386 0.153 up no no no no no SFA+blood Phenylacetic acid+stool 0 -0.645454545 0 serum_fattyacid stool_cometabolism 0.0386 0.785 up no no no no no SFA+blood Platelet activation 0 0 -0.440769231 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Porphyrin and chlorophyll metabolism 0 -0.626470588 0.404615385 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Prevotella 0 0.55364912 0 acetate-producing serum_fattyacid Genus 0.0386 0.287 up no no no no no SFA+blood Progesterone-mediated oocyte maturation 0.498245614 0 0 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood PUFA/MUFA+blood -0.454135338 0 0 serum_fattyacid serum_fattyacid 0.0386 0.00108 up no no dn no up SFA+blood PUFA+blood 0.888721805 0.862745098 0.730598291 serum_fattyacid serum_fattyacid 0.0386 0.212 up no no no no no SFA+blood Purine metabolism 0 -0.532352941 0 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Rap1 signaling pathway 0 0 -0.494615385 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood RIG-I-like receptor signaling pathway 0 0 0.434615385 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Salmonella infection 0 0 -0.423076923 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Shigellosis -0.510526316 0 0 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Sphingolipid signaling pathway 0 0 -0.477692308 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Thyroid hormone signaling pathway 0 0 -0.474615385 serum_fattyacid kegg 0.0386 NA up no no no no no SFA+blood Vibrio cholerae infection 0 0 -0.406153846 serum_fattyacid kegg 0.0386 NA up no no no no no Shigellosis ABC transporters -0.48 -0.453557312 0 kegg kegg NA NA no no no no up up Shigellosis Adipocytokine signaling pathway 0.554782609 0 0.623680824 kegg kegg NA NA no no no no no no Shigellosis Adrenergic signaling in cardiomyocytes 0.59826087 0.68083004 0 kegg kegg NA NA no no no no no up Shigellosis AGE-RAGE signaling pathway in diabetic complications -0.460869565 -0.551383399 -0.441956242 kegg kegg NA NA no no no no no no Shigellosis "Alanine, aspartate and glutamate metabolism" -0.529565217 -0.414031621 0 kegg kegg NA NA no no no no no no Shigellosis Aldosterone synthesis and secretion 0.509565217 0.596837945 0 kegg kegg NA NA no no no no up up Shigellosis Aldosterone-regulated sodium reabsorption 0 0 -0.63963964 kegg kegg NA NA no no no no no no Shigellosis alpha-Linolenic acid metabolism 0 -0.619565217 -0.472586873 kegg kegg NA NA no no no no no no Shigellosis Alzheimer disease 0.489565217 0.836956522 0 kegg kegg NA NA no no no no no no Shigellosis Amino sugar and nucleotide sugar metabolism 0 -0.502964427 0 kegg kegg NA NA no no no no no no Shigellosis Aminoacyl-tRNA biosynthesis -0.444347826 0 0 kegg kegg NA NA no no no no no no Shigellosis Amphetamine addiction 0.493913043 0.504940711 0 kegg kegg NA NA no no no no no no Shigellosis AMPK signaling pathway 0.408695652 0.462450593 0.700643501 kegg kegg NA NA no no no no no no Shigellosis Amyotrophic lateral sclerosis 0.583478261 0.763833992 0 kegg kegg NA NA no no no no no no Shigellosis Apelin signaling pathway 0.445217391 0.60770751 0 kegg kegg NA NA no no no no no no Shigellosis Apoptosis - multiple species 0 -0.543478261 0 kegg kegg NA NA no no no no no no Shigellosis Arachidonic acid metabolism 0 0 0.482368082 kegg kegg NA NA no no no no no no Shigellosis Arginine and proline metabolism 0 -0.463438735 0 kegg kegg NA NA no no no no up no Shigellosis Arginine biosynthesis -0.530434783 0 0 kegg kegg NA NA no no no no no no Shigellosis Ascorbate and aldarate metabolism 0 0 -0.425225225 kegg kegg NA NA no no no no no no Shigellosis Autophagy - animal 0 -0.419960474 -0.439124839 kegg kegg NA NA no no no no no no Shigellosis Bacteroides -0.474782609 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Shigellosis beta-Alanine metabolism -0.511304348 0 0 kegg kegg NA NA no no no no no no Shigellosis Bile secretion 0.580869565 0.463438735 0.581209781 kegg kegg NA NA no no no no no no Shigellosis Biosynthesis of amino acids -0.454782609 0 0 kegg kegg NA NA no no no no no no Shigellosis Biosynthesis of cofactors 0 0 0.530759331 kegg kegg NA NA no no no no no no Shigellosis Biosynthesis of unsaturated fatty acids -0.593043478 0 0 kegg kegg NA NA no no no no no no Shigellosis Calcium signaling pathway 0.454782609 0.636363636 0 kegg kegg NA NA no no no no up up Shigellosis cAMP signaling pathway 0.583478261 0 0 yes kegg kegg NA NA no no no no up up Shigellosis Carbohydrate digestion and absorption 0 -0.416007905 -0.667181467 kegg kegg NA NA no no no no no no Shigellosis Cardiac muscle contraction 0.475652174 0.778656126 0 kegg kegg NA NA no no no no no up Shigellosis Cholesterol metabolism 0.44173913 0 0 yes kegg kegg NA NA no no no no no up Shigellosis Cholinergic synapse 0 -0.485177866 -0.587902188 kegg kegg NA NA no no no no no no Shigellosis Circadian entrainment 0.44173913 0 0.473616474 kegg kegg NA NA no no no no up up Shigellosis Cocaine addiction 0.645217391 0.499011858 0.40978121 kegg kegg NA NA no no no no no no Shigellosis Complement and coagulation cascades 0 -0.433794466 0 kegg kegg NA NA no no no no no no Shigellosis Cortisol synthesis and secretion 0.552173913 0 0 kegg kegg NA NA no no no no no up Shigellosis Cushing syndrome 0.468695652 0 0 kegg kegg NA NA no no no no no up Shigellosis Cytosolic DNA-sensing pathway 0.526086957 0 0 kegg kegg NA NA no no no no no no Shigellosis Dopaminergic synapse 0.614782609 0.483201581 0 kegg kegg NA NA no no no no up no Shigellosis EGFR tyrosine kinase inhibitor resistance 0 0.570158103 0 kegg kegg NA NA no no no no no no Shigellosis Endocrine and other factor-regulated calcium reabsorption 0.503478261 0.66798419 0.423166023 kegg kegg NA NA no no no no no no Shigellosis ErbB signaling pathway 0 0 -0.667438867 kegg kegg NA NA no no no no no no Shigellosis Ether lipid metabolism 0.56173913 0 0 kegg kegg NA NA no no no no no no Shigellosis Fat digestion and absorption -0.436521739 -0.45256917 0 yes kegg kegg NA NA no no no no up up Shigellosis Fatty acid biosynthesis -0.564347826 -0.531620553 0 kegg kegg NA NA no no no no no no Shigellosis Fatty acid degradation -0.810434783 -0.698616601 0 kegg kegg NA NA no no no no no no Shigellosis Fatty acid elongation -0.467826087 0 0 kegg kegg NA NA no no no no no no Shigellosis Fatty acid metabolism -0.803478261 -0.683794466 0 kegg kegg NA NA no no no no no no Shigellosis Fc epsilon RI signaling pathway 0 -0.470355731 -0.54002574 kegg kegg NA NA no no no no no no Shigellosis Fc gamma R-mediated phagocytosis -0.65826087 -0.45256917 0 kegg kegg NA NA no no no no no no Shigellosis Ferroptosis 0.64173913 0.456521739 0.81029601 kegg kegg NA NA no no no no no no Shigellosis FoxO signaling pathway -0.516521739 -0.699604743 0 kegg kegg NA NA no no no no no no Shigellosis Fructose and mannose metabolism 0 -0.514822134 0 kegg kegg NA NA no no no no no no Shigellosis GABAergic synapse -0.432173913 0 0 kegg kegg NA NA no no no no up up Shigellosis Galactose metabolism -0.523478261 -0.779644269 0 kegg kegg NA NA no no no no no no Shigellosis Gap junction 0 0 0.414671815 kegg kegg NA NA no no no no no no Shigellosis Gastric acid secretion 0 0.475296443 0 kegg kegg NA NA no no no no no no Shigellosis Glucagon signaling pathway 0 0.542490119 0 kegg kegg NA NA no no no no no no Shigellosis Glutathione metabolism 0.416521739 0.586956522 0.654826255 kegg kegg NA NA no no no no no no Shigellosis Glycerolipid metabolism -0.415652174 -0.68083004 -0.592535393 kegg kegg NA NA no no no no no up Shigellosis Glycerophospholipid metabolism 0 -0.41798419 -0.521235521 kegg kegg NA NA no no no no no up Shigellosis "Glycine, serine and threonine metabolism" 0 0 0.541827542 kegg kegg NA NA no no no no up no Shigellosis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.545454545 -0.472329472 kegg kegg NA NA no no no no no no Shigellosis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.505019305 kegg kegg NA NA no no no no no no Shigellosis Glycosaminoglycan degradation 0 0 -0.594337194 kegg kegg NA NA no no no no no up Shigellosis Glyoxylate and dicarboxylate metabolism -0.622608696 0 0 kegg kegg NA NA no no no no no no Shigellosis GnRH secretion 0 0 -0.587129987 kegg kegg NA NA no no no no up up Shigellosis GnRH signaling pathway 0.522608696 0.416996047 0 kegg kegg NA NA no no no no no no Shigellosis Hedgehog signaling pathway 0 0 -0.463835264 kegg kegg NA NA no no no no no no Shigellosis Hematopoietic cell lineage -0.466956522 0 0 kegg kegg NA NA no no no no no no Shigellosis HIF-1 signaling pathway 0 0.543478261 0 kegg kegg NA NA no no no no no no Shigellosis Hippo signaling pathway - multiple species 0 -0.570158103 -0.652252252 kegg kegg NA NA no no no no no no Shigellosis Histidine metabolism -0.45826087 -0.447628458 0 kegg kegg NA NA no no no no no no Shigellosis Homologous recombination -0.447826087 0 0 kegg kegg NA NA no no no no no no Shigellosis Huntington disease 0.508695652 0.835968379 0 kegg kegg NA NA no no no no no no Shigellosis Inflammatory mediator regulation of TRP channels 0.46 0.533596838 0 kegg kegg NA NA no no no no no no Shigellosis Inositol phosphate metabolism -0.584347826 -0.597826087 -0.589189189 kegg kegg NA NA no no no no no no Shigellosis Insulin secretion 0.45826087 0.479249012 0 yes kegg kegg NA NA no no no no up up Shigellosis Insulin signaling pathway 0 0.561264822 0 kegg kegg NA NA no no no no no no Shigellosis JAK-STAT signaling pathway -0.485217391 -0.565217391 0 kegg kegg NA NA no no no no no no Shigellosis Long-term depression 0.546086957 0.416996047 0 kegg kegg NA NA no no no no no no Shigellosis Longevity regulating pathway 0 0 0.661518662 kegg kegg NA NA no no no no no no Shigellosis Longevity regulating pathway - multiple species -0.557391304 0 0 kegg kegg NA NA no no no no no no Shigellosis Lysine degradation 0 0 -0.486486486 kegg kegg NA NA no no no no no no Shigellosis Mannose type O-glycan biosynthesis 0 0 -0.476962677 kegg kegg NA NA no no no no no no Shigellosis MAPK signaling pathway -0.473913043 -0.704545455 -0.554440154 kegg kegg NA NA no no no no no no Shigellosis Maturity onset diabetes of the young 0 0 -0.437065637 kegg kegg NA NA no no no no up no Shigellosis Melanogenesis 0.428695652 0.641304348 0 kegg kegg NA NA no no no no no no Shigellosis Mineral absorption 0.766956522 0.734189723 0.851480051 kegg kegg NA NA no no no no no no Shigellosis Mismatch repair -0.445217391 0 0 kegg kegg NA NA no no no no no no Shigellosis Mitophagy - animal 0.917391304 0.91798419 0.957528958 kegg kegg NA NA no no no no no no Shigellosis Morphine addiction 0.590434783 0.425889328 0 kegg kegg NA NA no no no no up up Shigellosis mRNA surveillance pathway 0.459130435 0 0 kegg kegg NA NA no no no no no no Shigellosis mTOR signaling pathway 0.443478261 0.586956522 0 kegg kegg NA NA no no no no no no Shigellosis Mucin type O-glycan biosynthesis 0 -0.516798419 0 kegg kegg NA NA no no no no no no Shigellosis Necroptosis 0.64173913 0.606719368 0.836036036 kegg kegg NA NA no no no no no no Shigellosis NF-kappa B signaling pathway -0.496521739 0 0 kegg kegg NA NA no no no no no no Shigellosis Nicotinate and nicotinamide metabolism -0.49826087 -0.47826087 0 kegg kegg NA NA no no no no no no Shigellosis NOD-like receptor signaling pathway -0.552173913 -0.419960474 0 kegg kegg NA NA no no no no no no Shigellosis Non-alcoholic fatty liver disease 0.535652174 0.866600791 0 kegg kegg NA NA no no no no no no Shigellosis Non-homologous end-joining -0.550434783 0 0 kegg kegg NA NA no no no no no no Shigellosis Notch signaling pathway 0 0 -0.638352638 kegg kegg NA NA no no no no no no Shigellosis Olfactory transduction -0.431304348 0 0 kegg kegg NA NA no no no no no no Shigellosis Oscillospira 0 -0.456521739 0 LPS-producing kegg Genus NA 0.62 no no no no no no Shigellosis Osteoclast differentiation 0 -0.461462451 0 kegg kegg NA NA no no no no no no Shigellosis Other glycan degradation 0 -0.558300395 -0.668468468 kegg kegg NA NA no no no no no no Shigellosis Other types of O-glycan biosynthesis 0 0 -0.515572716 kegg kegg NA NA no no no no no no Shigellosis Ovarian steroidogenesis 0 0 0.461776062 kegg kegg NA NA no no no no up up Shigellosis Oxidative phosphorylation 0.487826087 0.821146245 0 kegg kegg NA NA no no no no no no Shigellosis Pancreatic secretion 0.629565217 0.549407115 0 kegg kegg NA NA no no no no no no Shigellosis Pantothenate and CoA biosynthesis -0.585217391 -0.605731225 0 kegg kegg NA NA no no no no no dn Shigellosis "Parathyroid hormone synthesis, secretion and action" 0.749565217 0.783596838 0.581209781 kegg kegg NA NA no no no no no no Shigellosis Parkinson disease 0.856521739 0.910079051 0.851222651 kegg kegg NA NA no no no no no no Shigellosis Pathways of neurodegeneration - multiple diseases 0.848695652 0.909090909 0.852252252 kegg kegg NA NA no no no no no no Shigellosis Peroxisome -0.693043478 -0.472332016 0 kegg kegg NA NA no no no no no no Shigellosis Phosphatidylinositol signaling system 0 0 -0.53024453 kegg kegg NA NA no no no no no no Shigellosis Platinum drug resistance 0 -0.536561265 0 kegg kegg NA NA no no no no no no Shigellosis Porphyrin and chlorophyll metabolism 0 0.448616601 0.619047619 kegg kegg NA NA no no no no no no Shigellosis Primary bile acid biosynthesis -0.480869565 0 0 kegg kegg NA NA no no no no no no Shigellosis Prion disease 0.45826087 0.790513834 0 kegg kegg NA NA no no no no no no Shigellosis Progesterone-mediated oocyte maturation 0 -0.464426877 -0.581467181 kegg kegg NA NA no no no no no no Shigellosis Prolactin signaling pathway 0 -0.433794466 0 kegg kegg NA NA no no no no no no Shigellosis Protein digestion and absorption -0.746956522 -0.794466403 -0.484169884 yes kegg kegg NA NA no no no no up up Shigellosis Protein export 0 0.526679842 0 kegg kegg NA NA no no no no no no Shigellosis Protein processing in endoplasmic reticulum 0 0 0.685199485 kegg kegg NA NA no no no no no no Shigellosis Purine metabolism 0 0.418972332 0.774259974 kegg kegg NA NA no no no no no no Shigellosis Pyrimidine metabolism -0.448695652 0 0 kegg kegg NA NA no no no no no no Shigellosis Ras signaling pathway 0 0 -0.404633205 yes kegg kegg NA NA no no no no up up Shigellosis Regulation of lipolysis in adipocytes 0.460869565 0 0 kegg kegg NA NA no no no no no no Shigellosis Relaxin signaling pathway 0.673043478 0 0 kegg kegg NA NA no no no no no no Shigellosis Renin secretion 0.487826087 0.577075099 0.502702703 kegg kegg NA NA no no no no no no Shigellosis Renin-angiotensin system 0 -0.431818182 0 kegg kegg NA NA no no no no no no Shigellosis Retinol metabolism -0.509565217 0 0 kegg kegg NA NA no no no no no no Shigellosis Retrograde endocannabinoid signaling 0 0.751976285 0 kegg kegg NA NA no no no no no up Shigellosis Ribosome 0.684347826 0.776679842 0.526383526 kegg kegg NA NA no no no no no no Shigellosis RNA degradation 0.426086957 0 0 kegg kegg NA NA no no no no no no Shigellosis RNA transport 0 0.475296443 0 kegg kegg NA NA no no no no no no Shigellosis Ruminococcus 0 0.425954748 0 kegg Genus NA 0.0679 no no no no no dn Shigellosis Selenocompound metabolism 0 -0.425889328 -0.461776062 kegg kegg NA NA no no no no no no Shigellosis Signaling pathways regulating pluripotency of stem cells 0 0 -0.507850708 kegg kegg NA NA no no no no no no Shigellosis SNARE interactions in vesicular transport 0 -0.585968379 0 kegg kegg NA NA no no no no no no Shigellosis Sphingolipid metabolism 0 0 -0.486229086 kegg kegg NA NA no no no no no no Shigellosis Sphingolipid signaling pathway 0 0 -0.657657658 kegg kegg NA NA no no no no no no Shigellosis Spinocerebellar ataxia 0 0 -0.41981982 kegg kegg NA NA no no no no no no Shigellosis Starch and sucrose metabolism 0 -0.663043478 0 kegg kegg NA NA no no no no no no Shigellosis Steroid hormone biosynthesis 0 0 -0.4002574 kegg kegg NA NA no no no no no no Shigellosis Sulfur metabolism 0 0 0.518404118 kegg kegg NA NA no no no no no no Shigellosis Taste transduction 0 0 -0.526126126 kegg kegg NA NA no no no no no up Shigellosis TGF-beta signaling pathway 0.435652174 0.42687747 0 kegg kegg NA NA no no no no no no Shigellosis Thermogenesis 0.566086957 0.790513834 0 kegg kegg NA NA no no no no no no Shigellosis Thyroid hormone synthesis 0.595652174 0.575098814 0.610553411 kegg kegg NA NA no no no no no no Shigellosis Tryptophan metabolism -0.484347826 0 0 kegg kegg NA NA no no no no up no Shigellosis Type II diabetes mellitus 0 -0.491106719 -0.616731017 kegg kegg NA NA no no no no no no Shigellosis Ubiquitin mediated proteolysis 0.884347826 0.858695652 0.954440154 kegg kegg NA NA no no no no no no Shigellosis "Valine, leucine and isoleucine degradation" -0.408695652 0 0 kegg kegg NA NA no no no no no no Shigellosis Various types of N-glycan biosynthesis 0 0 -0.498584299 kegg kegg NA NA no no no no no no Shigellosis Vascular smooth muscle contraction 0.786956522 0.698616601 0.447361647 kegg kegg NA NA no no no no no no Shigellosis Vasopressin-regulated water reabsorption 0.517391304 0.596837945 0.466666667 kegg kegg NA NA no no no no no no Shigellosis VEGF signaling pathway 0 0 -0.648391248 kegg kegg NA NA no no no no no no Shigellosis Vibrio cholerae infection 0 0.421936759 0 kegg kegg NA NA no no no no no no Shigellosis Vitamin digestion and absorption 0 -0.558300395 -0.493951094 kegg kegg NA NA no no no no no no Shigellosis Wnt signaling pathway 0 0 -0.48983269 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells 2-Oxocarboxylic acid metabolism -0.582608696 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells ABC transporters 0 0.565217391 0 kegg kegg NA NA no no no no up up Signaling pathways regulating pluripotency of stem cells Adherens junction 0 -0.429841897 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Adrenergic signaling in cardiomyocytes 0.519130435 0 0 kegg kegg NA NA no no no no no up Signaling pathways regulating pluripotency of stem cells Alistipes 0 0.444280709 0 kegg Genus NA 0.0114 no no no no up no Signaling pathways regulating pluripotency of stem cells alpha-Linolenic acid metabolism -0.545217391 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Amino sugar and nucleotide sugar metabolism -0.633913043 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Apoptosis - multiple species 0 0.553359684 0.471557272 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Arachidonic acid metabolism -0.591304348 0 -0.68030888 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Arginine biosynthesis 0 0 -0.410553411 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Autophagy - animal 0.493913043 0.449604743 0.476705277 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Autophagy - other 0.568695652 0.684782609 0.740540541 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Axon guidance 0.585217391 0 0 kegg kegg NA NA no no no no up up Signaling pathways regulating pluripotency of stem cells Basal transcription factors 0 0 0.604375804 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells beta-Alanine metabolism -0.714782609 -0.523715415 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Biosynthesis of amino acids -0.702608696 -0.419960474 -0.664350064 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Biosynthesis of cofactors -0.486086957 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Biosynthesis of unsaturated fatty acids -0.473913043 -0.556324111 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Butanoate metabolism -0.620869565 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Calcium signaling pathway 0.656521739 0 0.423423423 kegg kegg NA NA no no no no up up Signaling pathways regulating pluripotency of stem cells cAMP signaling pathway 0.674782609 0 0 yes kegg kegg NA NA no no no no up up Signaling pathways regulating pluripotency of stem cells Carbon metabolism -0.76173913 -0.586956522 -0.584298584 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Cardiac muscle contraction 0.620869565 0 0 kegg kegg NA NA no no no no no up Signaling pathways regulating pluripotency of stem cells Cell cycle 0 0.416007905 0.727413127 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Citrate cycle (TCA cycle) -0.467826087 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Clostridium 0 -0.41872905 0 kegg Genus NA 0.925 no no no no no no Signaling pathways regulating pluripotency of stem cells Collinsella 0 0 -0.408658327 kegg Genus NA 0.128 no no no no no no Signaling pathways regulating pluripotency of stem cells Cytokine-cytokine receptor interaction 0 -0.510869565 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Drug metabolism - other enzymes -0.723478261 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Endocrine resistance 0.485217391 0.473320158 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells ErbB signaling pathway 0.80173913 0.779644269 0.841441441 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Ether lipid metabolism 0.431304348 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Fanconi anemia pathway 0 0 0.519176319 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Fatty acid elongation -0.66173913 -0.580039526 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Fatty acid metabolism -0.534782609 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Ferroptosis 0 0 -0.578635779 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Focal adhesion 0 -0.526679842 0 kegg kegg NA NA no no no no up up Signaling pathways regulating pluripotency of stem cells FoxO signaling pathway 0 0.41798419 0.545431145 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Fructose and mannose metabolism -0.631304348 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Galactose metabolism -0.61826087 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Gemmiger 0 0.441147595 0 butyrate-producing kegg Genus NA 0.595 no no no no no no Signaling pathways regulating pluripotency of stem cells Glutathione metabolism -0.42173913 0 -0.617245817 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Glycerolipid metabolism 0 0.489130435 0.558815959 kegg kegg NA NA no no no no no up Signaling pathways regulating pluripotency of stem cells Glycerophospholipid metabolism 0 0.51284585 0.63011583 kegg kegg NA NA no no no no no up Signaling pathways regulating pluripotency of stem cells Glycolysis / Gluconeogenesis -0.682608696 -0.469367589 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.443675889 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Glycosaminoglycan biosynthesis - keratan sulfate 0.507826087 0.571146245 0.64967825 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Glycosphingolipid biosynthesis - lacto and neolacto series 0.482608696 0 0.44993565 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Glyoxylate and dicarboxylate metabolism 0 0 -0.419047619 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Hedgehog signaling pathway 0.751304348 0.538537549 0.837323037 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Histidine metabolism -0.450434783 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Homologous recombination 0 0 0.521492921 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Inositol phosphate metabolism 0 0.608695652 0.671557272 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Lachnospira 0 -0.529280965 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Signaling pathways regulating pluripotency of stem cells Lysine degradation 0.416521739 0.805335968 0.703732304 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Lysosome 0 -0.468379447 -0.424967825 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Mannose type O-glycan biosynthesis 0.64173913 0.804347826 0.670785071 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells MAPK signaling pathway 0 0 0.651737452 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Metabolism of xenobiotics by cytochrome P450 -0.474782609 0 -0.430630631 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells mRNA surveillance pathway 0.69826087 0.545454545 0.712226512 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Mucin type O-glycan biosynthesis 0 0.436758893 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells N-Glycan biosynthesis 0 0 0.646332046 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Necroptosis 0 0 -0.508365508 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Neuroactive ligand-receptor interaction -0.409565217 -0.503952569 -0.465379665 kegg kegg NA NA no no no up up up Signaling pathways regulating pluripotency of stem cells Non-homologous end-joining -0.58173913 -0.448616601 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Notch signaling pathway 0.47826087 0.671936759 0.578378378 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells One carbon pool by folate 0 0 0.445045045 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Oocyte meiosis 0 0 0.513256113 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Other glycan degradation 0 0.472332016 0.402831403 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Other types of O-glycan biosynthesis 0.509565217 0.742094862 0.761647362 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Oxidative phosphorylation 0.548695652 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells p53 signaling pathway 0.493043478 0.531620553 0.538223938 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Pentose phosphate pathway -0.463478261 -0.460474308 -0.587644788 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Peroxisome 0 0 -0.458172458 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Phagosome -0.496521739 0 -0.574002574 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Phenylalanine metabolism -0.534782609 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Phosphatidylinositol signaling system 0.774782609 0.480237154 0.815701416 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Platinum drug resistance 0 0.678853755 0.643243243 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Porphyrin and chlorophyll metabolism 0 0 -0.423938224 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Primary bile acid biosynthesis -0.46 -0.538537549 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Protein export 0.422608696 0 0.422393822 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Pyrimidine metabolism -0.633913043 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Rap1 signaling pathway 0 -0.424901186 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Ras signaling pathway 0.473043478 0 0.600772201 yes kegg kegg NA NA no no no no up up Signaling pathways regulating pluripotency of stem cells Retinol metabolism -0.505217391 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Ribosome 0.520869565 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Ribosome biogenesis in eukaryotes 0 0 0.611325611 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells RNA degradation 0.675652174 0 0.672072072 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Ruminococcus 0 -0.525509289 0 kegg Genus NA 0.0679 no no no no no dn Signaling pathways regulating pluripotency of stem cells Selenocompound metabolism 0 0.496047431 0.552123552 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Sphingolipid signaling pathway 0.677391304 0 0.553410553 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Spliceosome 0 0.713438735 0.687258687 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Starch and sucrose metabolism -0.469565217 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Steroid hormone biosynthesis -0.619130435 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Sulfur metabolism -0.60173913 0 -0.58996139 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Taurine and hypotaurine metabolism 0.446086957 0.706521739 0.565250965 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Terpenoid backbone biosynthesis 0 0 0.449163449 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells TGF-beta signaling pathway 0.516521739 0 0.575032175 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Tight junction -0.548695652 -0.641304348 -0.7003861 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Tryptophan metabolism -0.603478261 0 0 kegg kegg NA NA no no no no up no Signaling pathways regulating pluripotency of stem cells Tyrosine metabolism -0.562608696 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Ubiquinone and other terpenoid-quinone biosynthesis -0.491304348 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells "Valine, leucine and isoleucine degradation" -0.493043478 0 0 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Various types of N-glycan biosynthesis 0 0 0.607979408 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells VEGF signaling pathway 0.744347826 0 0.66023166 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Viral protein interaction with cytokine and cytokine receptor 0 -0.590909091 -0.494723295 kegg kegg NA NA no no no no no no Signaling pathways regulating pluripotency of stem cells Wnt signaling pathway 0.623478261 0 0.717117117 kegg kegg NA NA no no no no no no Small cell lung cancer 2-Oxocarboxylic acid metabolism 0 -0.46541502 -0.549292149 kegg kegg NA NA no no up no no no Small cell lung cancer ABC transporters 0.488695652 0.449604743 0 kegg kegg NA NA no no up no up up Small cell lung cancer Acute myeloid leukemia 0 0.710474308 0.422393822 kegg kegg NA NA no no up no no no Small cell lung cancer Adherens junction -0.54173913 -0.647233202 -0.588159588 kegg kegg NA NA no no up no no no Small cell lung cancer Adipocytokine signaling pathway 0 0.684782609 0.583783784 kegg kegg NA NA no no up no no no Small cell lung cancer AGE-RAGE signaling pathway in diabetic complications 0 0.633399209 0 kegg kegg NA NA no no up no no no Small cell lung cancer "Alanine, aspartate and glutamate metabolism" 0 0.588932806 0 kegg kegg NA NA no no up no no no Small cell lung cancer Aldosterone-regulated sodium reabsorption 0 0.538537549 0 kegg kegg NA NA no no up no no no Small cell lung cancer alpha-Linolenic acid metabolism 0 0 -0.473873874 kegg kegg NA NA no no up no no no Small cell lung cancer Alzheimer disease 0 -0.529644269 0 kegg kegg NA NA no no up no no no Small cell lung cancer Amoebiasis 0 0.518774704 0 kegg kegg NA NA no no up no no no Small cell lung cancer Amphetamine addiction 0 -0.546442688 0 kegg kegg NA NA no no up no no no Small cell lung cancer Amyotrophic lateral sclerosis 0 -0.545454545 0 kegg kegg NA NA no no up no no no Small cell lung cancer Apelin signaling pathway 0 -0.587944664 0 kegg kegg NA NA no no up no no no Small cell lung cancer Apoptosis 0 0.622529644 0 kegg kegg NA NA no no up no no no Small cell lung cancer Apoptosis - multiple species 0.562608696 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Arachidonic acid metabolism -0.427826087 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Arginine and proline metabolism 0 0.611660079 0 kegg kegg NA NA no no up no up no Small cell lung cancer Arginine biosynthesis 0 0.546442688 0 kegg kegg NA NA no no up no no no Small cell lung cancer Autophagy - animal 0.51826087 0.834980237 0 kegg kegg NA NA no no up no no no Small cell lung cancer Autophagy - other 0.593043478 0.583003953 0.43989704 kegg kegg NA NA no no up no no no Small cell lung cancer B cell receptor signaling pathway 0.439130435 0.828063241 0.520978121 kegg kegg NA NA no no up no no no Small cell lung cancer Bacterial invasion of epithelial cells -0.515652174 -0.605731225 -0.708880309 kegg kegg NA NA no no up no no no Small cell lung cancer Basal cell carcinoma 0.537391304 0 0.564478764 kegg kegg NA NA no no up no no no Small cell lung cancer Basal transcription factors 0.434782609 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Base excision repair 0.55826087 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer beta-Alanine metabolism 0 -0.593873518 -0.687516088 kegg kegg NA NA no no up no no no Small cell lung cancer Biosynthesis of cofactors 0 -0.470355731 0 kegg kegg NA NA no no up no no no Small cell lung cancer Biosynthesis of unsaturated fatty acids 0 -0.530632411 -0.65997426 kegg kegg NA NA no no up no no no Small cell lung cancer Bladder cancer 0 0.675889328 0 kegg kegg NA NA no no up no no no Small cell lung cancer Butanoate metabolism 0 -0.677865613 -0.482625483 kegg kegg NA NA no no up no no no Small cell lung cancer C-type lectin receptor signaling pathway 0.455652174 0.82312253 0.631917632 kegg kegg NA NA no no up no no no Small cell lung cancer Calcium signaling pathway 0 0 0.441184041 kegg kegg NA NA no no up no up up Small cell lung cancer cAMP signaling pathway 0 0.613636364 0.668983269 yes kegg kegg NA NA no no up no up up Small cell lung cancer Carbohydrate digestion and absorption 0.548695652 0.691699605 0 kegg kegg NA NA no no up no no no Small cell lung cancer Carbon metabolism -0.422608696 0 -0.604375804 kegg kegg NA NA no no up no no no Small cell lung cancer Cardiac muscle contraction 0 -0.486166008 0 kegg kegg NA NA no no up no no up Small cell lung cancer Cellular senescence 0 0.43083004 0 kegg kegg NA NA no no up no no no Small cell lung cancer Chagas disease 0 0.770750988 0.408494208 kegg kegg NA NA no no up no no no Small cell lung cancer Chemical carcinogenesis - DNA adducts -0.455652174 0 -0.490604891 kegg kegg NA NA no no up no no no Small cell lung cancer Chemical carcinogenesis - receptor activation 0 0 0.474131274 kegg kegg NA NA no no up no no no Small cell lung cancer Chemokine signaling pathway 0 0.542490119 0 kegg kegg NA NA no no up no no no Small cell lung cancer Chronic myeloid leukemia 0.759130435 0.910079051 0.848906049 kegg kegg NA NA no no up no no no Small cell lung cancer Circadian entrainment -0.543478261 -0.692687747 0 kegg kegg NA NA no no up no up up Small cell lung cancer Circadian rhythm 0.424347826 0 0.440669241 kegg kegg NA NA no no up no no no Small cell lung cancer Citrate cycle (TCA cycle) 0 -0.695652174 -0.456113256 kegg kegg NA NA no no up no no no Small cell lung cancer Clostridium 0 -0.437067548 0 kegg Genus NA 0.925 no no up no no no Small cell lung cancer Cocaine addiction 0 0 0.512741313 kegg kegg NA NA no no up no no no Small cell lung cancer Collecting duct acid secretion -0.516521739 -0.419960474 0 kegg kegg NA NA no no up no no no Small cell lung cancer Colorectal cancer 0.475652174 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Complement and coagulation cascades 0 0 -0.425482625 kegg kegg NA NA no no up no no no Small cell lung cancer Coronavirus disease - COVID-19 0 -0.494071146 0 kegg kegg NA NA no no up no no no Small cell lung cancer Cortisol synthesis and secretion 0 0 0.462548263 kegg kegg NA NA no no up no no up Small cell lung cancer Cushing syndrome 0 0 0.502445302 kegg kegg NA NA no no up no no up Small cell lung cancer Cysteine and methionine metabolism 0 -0.685770751 0 kegg kegg NA NA no no up no no no Small cell lung cancer Cytokine-cytokine receptor interaction 0 0 -0.47027027 kegg kegg NA NA no no up no no no Small cell lung cancer Cytosolic DNA-sensing pathway 0 0.731225296 0 kegg kegg NA NA no no up no no no Small cell lung cancer DNA replication 0 -0.64229249 0 kegg kegg NA NA no no up no no no Small cell lung cancer Dopaminergic synapse 0 -0.580039526 0 kegg kegg NA NA no no up no up no Small cell lung cancer Drug metabolism - cytochrome P450 -0.449565217 -0.742094862 -0.597168597 kegg kegg NA NA no no up no no no Small cell lung cancer Drug metabolism - other enzymes -0.473043478 -0.717391304 0 kegg kegg NA NA no no up no no no Small cell lung cancer EGFR tyrosine kinase inhibitor resistance 0.489565217 -0.427865613 0 kegg kegg NA NA no no up no no no Small cell lung cancer Endocrine resistance 0 0 0.412355212 kegg kegg NA NA no no up no no no Small cell lung cancer Endometrial cancer 0.530434783 0.792490119 0.518404118 kegg kegg NA NA no no up no no no Small cell lung cancer Epithelial cell signaling in Helicobacter pylori infection 0 0.604743083 0 kegg kegg NA NA no no up no no no Small cell lung cancer ErbB signaling pathway 0.606086957 0.668972332 0 kegg kegg NA NA no no up no no no Small cell lung cancer Estrogen signaling pathway 0 -0.70256917 0 kegg kegg NA NA no no up no no no Small cell lung cancer Fatty acid biosynthesis 0 0.544466403 0 kegg kegg NA NA no no up no no no Small cell lung cancer Fatty acid degradation 0 0 -0.415186615 kegg kegg NA NA no no up no no no Small cell lung cancer Fatty acid elongation -0.437391304 -0.598814229 -0.713770914 kegg kegg NA NA no no up no no no Small cell lung cancer Fatty acid metabolism 0 0 -0.464607465 kegg kegg NA NA no no up no no no Small cell lung cancer Fc epsilon RI signaling pathway 0 0.647233202 0 kegg kegg NA NA no no up no no no Small cell lung cancer Ferroptosis -0.413043478 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Focal adhesion -0.497391304 -0.693675889 -0.641184041 kegg kegg NA NA no no up no up up Small cell lung cancer FoxO signaling pathway 0 0.554347826 0 kegg kegg NA NA no no up no no no Small cell lung cancer GABAergic synapse 0 0.424901186 0 kegg kegg NA NA no no up no up up Small cell lung cancer Gastric acid secretion -0.580869565 -0.696640316 -0.476447876 kegg kegg NA NA no no up no no no Small cell lung cancer Glucagon signaling pathway 0 -0.480237154 0 kegg kegg NA NA no no up no no no Small cell lung cancer Glutamatergic synapse -0.406086957 0 0 kegg kegg NA NA no no up no up up Small cell lung cancer Glutathione metabolism 0 -0.516798419 0 kegg kegg NA NA no no up no no no Small cell lung cancer Glycerolipid metabolism 0.483478261 0.462450593 0 kegg kegg NA NA no no up no no up Small cell lung cancer Glycerophospholipid metabolism 0.636521739 0 0 kegg kegg NA NA no no up no no up Small cell lung cancer Glycolysis / Gluconeogenesis 0 -0.670948617 -0.640926641 kegg kegg NA NA no no up no no no Small cell lung cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.760869565 0 kegg kegg NA NA no no up no no no Small cell lung cancer Glycosphingolipid biosynthesis - globo and isoglobo series -0.697391304 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.596837945 0.432432432 kegg kegg NA NA no no up no no no Small cell lung cancer Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.504347826 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Glyoxylate and dicarboxylate metabolism 0 0.539525692 0 kegg kegg NA NA no no up no no no Small cell lung cancer GnRH secretion 0.566086957 0.70256917 0 kegg kegg NA NA no no up no up up Small cell lung cancer "Growth hormone synthesis, secretion and action" 0 0.45256917 0.623166023 kegg kegg NA NA no no up no no no Small cell lung cancer Hematopoietic cell lineage 0 -0.425889328 -0.594851995 kegg kegg NA NA no no up no no no Small cell lung cancer Hepatitis B 0.63826087 0.859683794 0.6998713 kegg kegg NA NA no no up no no no Small cell lung cancer Hepatitis C 0 0.772727273 0.746718147 kegg kegg NA NA no no up no no no Small cell lung cancer HIF-1 signaling pathway 0 -0.514822134 0 kegg kegg NA NA no no up no no no Small cell lung cancer Hippo signaling pathway -0.449565217 -0.663043478 -0.594594595 kegg kegg NA NA no no up no no no Small cell lung cancer Hippo signaling pathway - multiple species 0 0.562252964 0 kegg kegg NA NA no no up no no no Small cell lung cancer Histidine metabolism 0 0 -0.529472329 kegg kegg NA NA no no up no no no Small cell lung cancer Human papillomavirus infection 0 0.48715415 0 kegg kegg NA NA no no up no no no Small cell lung cancer Huntington disease 0 -0.515810277 0 kegg kegg NA NA no no up no no no Small cell lung cancer Inflammatory mediator regulation of TRP channels 0 -0.555335968 0 kegg kegg NA NA no no up no no no Small cell lung cancer Inositol phosphate metabolism 0.52173913 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Insulin resistance 0.774782609 0.943675889 0.770913771 kegg kegg NA NA no no up no no no Small cell lung cancer Insulin secretion 0 0 0.492149292 yes kegg kegg NA NA no no up no up up Small cell lung cancer Insulin signaling pathway 0 -0.528656126 0 kegg kegg NA NA no no up no no no Small cell lung cancer JAK-STAT signaling pathway 0 0.743083004 0 kegg kegg NA NA no no up no no no Small cell lung cancer Lachnospira 0 -0.5193971 0 butyrate-producing kegg Genus NA 0.279 no no up no no no Small cell lung cancer Leukocyte transendothelial migration -0.527826087 0 -0.573745174 kegg kegg NA NA no no up no no no Small cell lung cancer Long-term potentiation 0 -0.557312253 0 kegg kegg NA NA no no up no no up Small cell lung cancer Longevity regulating pathway 0 0 0.444015444 kegg kegg NA NA no no up no no no Small cell lung cancer Longevity regulating pathway - multiple species 0 0 -0.474646075 kegg kegg NA NA no no up no no no Small cell lung cancer Lysine degradation 0.786086957 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Mannose type O-glycan biosynthesis 0.610434783 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Measles 0.5 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Melanogenesis 0 -0.501976285 0 kegg kegg NA NA no no up no no no Small cell lung cancer Melanoma 0.412173913 0.78458498 0.456885457 kegg kegg NA NA no no up no no no Small cell lung cancer Metabolism of xenobiotics by cytochrome P450 -0.531304348 -0.772727273 -0.67027027 kegg kegg NA NA no no up no no no Small cell lung cancer MicroRNAs in cancer 0.491304348 0.911067194 0 kegg kegg NA NA no no up no no no Small cell lung cancer Mismatch repair 0 -0.661067194 -0.428056628 kegg kegg NA NA no no up no no no Small cell lung cancer mRNA surveillance pathway 0.534782609 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer mTOR signaling pathway 0 -0.421936759 0 kegg kegg NA NA no no up no no no Small cell lung cancer N-Glycan biosynthesis 0 -0.485177866 0 kegg kegg NA NA no no up no no no Small cell lung cancer Natural killer cell mediated cytotoxicity -0.443478261 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Neuroactive ligand-receptor interaction -0.466956522 0 0 kegg kegg NA NA no no up up up up Small cell lung cancer Neurotrophin signaling pathway 0.446086957 0.829051383 0.515572716 kegg kegg NA NA no no up no no no Small cell lung cancer Neutrophil extracellular trap formation -0.45826087 0 -0.421364221 kegg kegg NA NA no no up no no no Small cell lung cancer NF-kappa B signaling pathway 0.714782609 0.893280632 0.714543115 kegg kegg NA NA no no up no no no Small cell lung cancer Nicotinate and nicotinamide metabolism 0 0.492094862 0 kegg kegg NA NA no no up no no no Small cell lung cancer Nicotine addiction 0 0 0.504761905 kegg kegg NA NA no no up no up up Small cell lung cancer Nitrogen metabolism 0 0.542490119 0 kegg kegg NA NA no no up no no no Small cell lung cancer NOD-like receptor signaling pathway 0 0.684782609 0 kegg kegg NA NA no no up no no no Small cell lung cancer Non-alcoholic fatty liver disease 0 -0.435770751 0 kegg kegg NA NA no no up no no no Small cell lung cancer Non-homologous end-joining 0 -0.674901186 -0.546460746 kegg kegg NA NA no no up no no no Small cell lung cancer Notch signaling pathway 0 0.565217391 0 kegg kegg NA NA no no up no no no Small cell lung cancer Nucleotide excision repair 0 -0.597826087 0 kegg kegg NA NA no no up no no no Small cell lung cancer One carbon pool by folate 0 -0.614624506 0 kegg kegg NA NA no no up no no no Small cell lung cancer Oocyte meiosis 0 -0.662055336 0 kegg kegg NA NA no no up no no no Small cell lung cancer Osteoclast differentiation 0 0.565217391 0 kegg kegg NA NA no no up no no no Small cell lung cancer Other glycan degradation 0 0.485177866 0 kegg kegg NA NA no no up no no no Small cell lung cancer Other types of O-glycan biosynthesis 0.74 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Oxidative phosphorylation 0 -0.528656126 0 kegg kegg NA NA no no up no no no Small cell lung cancer Oxytocin signaling pathway -0.604347826 -0.557312253 -0.519176319 kegg kegg NA NA no no up no no no Small cell lung cancer p53 signaling pathway 0.752173913 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Parkinson disease 0 -0.476284585 0 kegg kegg NA NA no no up no no no Small cell lung cancer Pathogenic Escherichia coli infection 0 0 -0.431145431 kegg kegg NA NA no no up no no no Small cell lung cancer Pathways in cancer 0.573913043 0.785573123 0.67027027 kegg kegg NA NA no no up no no no Small cell lung cancer Pathways of neurodegeneration - multiple diseases 0 -0.454545455 0 kegg kegg NA NA no no up no no no Small cell lung cancer Pentose and glucuronate interconversions 0 -0.612648221 0 kegg kegg NA NA no no up no no no Small cell lung cancer Pertussis -0.434782609 0 0 kegg kegg NA NA no no up no no dn Small cell lung cancer Phagosome -0.426086957 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Phenylalanine metabolism 0 -0.678853755 -0.53024453 kegg kegg NA NA no no up no no no Small cell lung cancer Phospholipase D signaling pathway 0 0.626482213 0 kegg kegg NA NA no no up no up up Small cell lung cancer Phototransduction -0.491304348 -0.76284585 -0.411840412 kegg kegg NA NA no no up no no no Small cell lung cancer PI3K-Akt signaling pathway 0.503478261 0 0 yes kegg kegg NA NA no no up no up up Small cell lung cancer Platelet activation -0.643478261 -0.632411067 -0.455598456 kegg kegg NA NA no no up no no no Small cell lung cancer Platinum drug resistance 0.587826087 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer PPAR signaling pathway 0 0.559288538 0 kegg kegg NA NA no no up no no no Small cell lung cancer Primary bile acid biosynthesis 0 -0.616600791 -0.66975547 kegg kegg NA NA no no up no no no Small cell lung cancer Prion disease 0 -0.589920949 0 kegg kegg NA NA no no up no no no Small cell lung cancer Progesterone-mediated oocyte maturation 0.432173913 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Prolactin signaling pathway 0 0.684782609 0.493436293 kegg kegg NA NA no no up no no no Small cell lung cancer Propanoate metabolism 0 -0.673913043 0 kegg kegg NA NA no no up no no no Small cell lung cancer Prostate cancer 0.67826087 0.91798419 0.75958816 kegg kegg NA NA no no up no no no Small cell lung cancer Proteasome 0 -0.674901186 0 kegg kegg NA NA no no up no no no Small cell lung cancer Protein export 0 -0.583992095 0 kegg kegg NA NA no no up no no no Small cell lung cancer Protein processing in endoplasmic reticulum 0 -0.446640316 0 kegg kegg NA NA no no up no no no Small cell lung cancer Proteoglycans in cancer 0.437391304 -0.448616601 0 kegg kegg NA NA no no up no no no Small cell lung cancer Proximal tubule bicarbonate reclamation 0 -0.580039526 0 kegg kegg NA NA no no up no no no Small cell lung cancer Pyramidobacter 0 0 0.439150809 kegg Genus NA 0.45 no no up no no no Small cell lung cancer Pyrimidine metabolism 0 -0.626482213 0 kegg kegg NA NA no no up no no no Small cell lung cancer Pyruvate metabolism 0 -0.701581028 0 kegg kegg NA NA no no up no no no Small cell lung cancer Rap1 signaling pathway -0.552173913 -0.445652174 -0.419305019 kegg kegg NA NA no no up no no no Small cell lung cancer Ras signaling pathway 0 -0.537549407 0 yes kegg kegg NA NA no no up no up up Small cell lung cancer Regulation of actin cytoskeleton -0.713913043 -0.623517787 -0.700643501 kegg kegg NA NA no no up no no no Small cell lung cancer Relaxin signaling pathway 0 0.745059289 0.67001287 kegg kegg NA NA no no up no no no Small cell lung cancer Renin secretion -0.540869565 -0.694664032 0 kegg kegg NA NA no no up no no no Small cell lung cancer Retinol metabolism 0 -0.529644269 -0.452252252 kegg kegg NA NA no no up no no no Small cell lung cancer Retrograde endocannabinoid signaling 0 -0.591897233 0 kegg kegg NA NA no no up no no up Small cell lung cancer Ribosome 0 -0.506916996 0 kegg kegg NA NA no no up no no no Small cell lung cancer Ribosome biogenesis in eukaryotes 0.55826087 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer RIG-I-like receptor signaling pathway 0.54173913 0.875494071 0.707335907 kegg kegg NA NA no no up no no no Small cell lung cancer RNA degradation 0.46173913 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer RNA polymerase 0.472173913 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Roseburia -0.533043478 0 0 butyrate-producing kegg Genus NA 0.495 no no up no no no Small cell lung cancer Salivary secretion -0.622608696 -0.51284585 0 kegg kegg NA NA no no up no no no Small cell lung cancer Salmonella infection 0 0 -0.611325611 kegg kegg NA NA no no up no no no Small cell lung cancer Selenocompound metabolism 0.670434783 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Serotonergic synapse -0.407826087 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Signaling pathways regulating pluripotency of stem cells 0.555652174 0.524703557 0 kegg kegg NA NA no no up no no no Small cell lung cancer SNARE interactions in vesicular transport 0.55826087 0.615612648 0 kegg kegg NA NA no no up no no no Small cell lung cancer Sphingolipid signaling pathway 0 0.444664032 0 kegg kegg NA NA no no up no no no Small cell lung cancer Spinocerebellar ataxia 0.482608696 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Spliceosome 0.606086957 0 0 kegg kegg NA NA no no up no no no Small cell lung cancer Staphylococcus aureus infection 0 0 -0.42985843 kegg kegg NA NA no no up up no no Small cell lung cancer Steroid biosynthesis 0 -0.692687747 -0.415701416 kegg kegg NA NA no no up no no no Small cell lung cancer Steroid hormone biosynthesis -0.513043478 -0.672924901 0 kegg kegg NA NA no no up no no no Small cell lung cancer Sulfur metabolism 0 -0.470355731 0 kegg kegg NA NA no no up no no no Small cell lung cancer Synthesis and degradation of ketone bodies 0 -0.580039526 0 kegg kegg NA NA no no up no no no Small cell lung cancer T cell receptor signaling pathway 0.52173913 0.72826087 0 kegg kegg NA NA no no up no no no Small cell lung cancer Taste transduction 0 -0.485177866 0 kegg kegg NA NA no no up no no up Small cell lung cancer Taurine and hypotaurine metabolism 0.707826087 0.635375494 0 kegg kegg NA NA no no up no no no Small cell lung cancer TGF-beta signaling pathway 0 -0.509881423 0 kegg kegg NA NA no no up no no no Small cell lung cancer Th1 and Th2 cell differentiation 0 0.502964427 0 kegg kegg NA NA no no up no no no Small cell lung cancer Th17 cell differentiation 0.454782609 0.571146245 0 kegg kegg NA NA no no up no no no Small cell lung cancer Thermogenesis 0 -0.579051383 0 kegg kegg NA NA no no up no no no Small cell lung cancer Thiamine metabolism 0 -0.528656126 0 kegg kegg NA NA no no up no no no Small cell lung cancer Thyroid hormone signaling pathway 0 -0.455533597 -0.446846847 kegg kegg NA NA no no up no no no Small cell lung cancer Tight junction -0.500869565 -0.686758893 -0.663063063 kegg kegg NA NA no no up no no no Small cell lung cancer TNF signaling pathway 0.59826087 0.928853755 0.613899614 kegg kegg NA NA no no up no no no Small cell lung cancer Toll-like receptor signaling pathway 0 0.746047431 0 yes kegg kegg NA NA no no up no no no Small cell lung cancer Transcriptional misregulation in cancer 0.54 0.81916996 0.692664093 kegg kegg NA NA no no up no no no Small cell lung cancer Tryptophan metabolism 0 -0.710474308 -0.456113256 kegg kegg NA NA no no up no up no Small cell lung cancer Tuberculosis 0 0 -0.515057915 kegg kegg NA NA no no up no no dn Small cell lung cancer Type II diabetes mellitus 0.47826087 0.787549407 0 kegg kegg NA NA no no up no no no Small cell lung cancer Tyrosine metabolism -0.457391304 -0.780632411 -0.668725869 kegg kegg NA NA no no up no no no Small cell lung cancer Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.611660079 0 kegg kegg NA NA no no up no no no Small cell lung cancer "Valine, leucine and isoleucine degradation" 0 -0.67687747 -0.552380952 kegg kegg NA NA no no up no no no Small cell lung cancer Vascular smooth muscle contraction 0 -0.656126482 0 kegg kegg NA NA no no up no no no Small cell lung cancer Vasopressin-regulated water reabsorption 0 -0.472332016 0 kegg kegg NA NA no no up no no no Small cell lung cancer VEGF signaling pathway 0 0.581027668 0 kegg kegg NA NA no no up no no no Small cell lung cancer Vibrio cholerae infection -0.586956522 -0.626482213 -0.45045045 kegg kegg NA NA no no up no no no Small cell lung cancer Viral carcinogenesis 0 0.531620553 0 kegg kegg NA NA no no up no no no SMB53 Olsenella 0 0.434324473 0 Genus Genus 0.525 0.269 no no no no no no SNARE interactions in vesicular transport ABC transporters 0.666086957 0.651185771 0.584298584 kegg kegg NA NA no no no no up up SNARE interactions in vesicular transport "Alanine, aspartate and glutamate metabolism" 0 0.462450593 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport alpha-Linolenic acid metabolism 0 0.587944664 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Aminoacyl-tRNA biosynthesis 0.429565217 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Antifolate resistance 0.432173913 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Arginine and proline metabolism 0 0.546442688 0 kegg kegg NA NA no no no no up no SNARE interactions in vesicular transport Ascorbate and aldarate metabolism 0.42173913 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Base excision repair 0.424347826 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Calcium signaling pathway -0.490434783 -0.493083004 0 kegg kegg NA NA no no no no up up SNARE interactions in vesicular transport Cysteine and methionine metabolism 0 -0.513833992 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Cytokine-cytokine receptor interaction -0.408695652 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Drug metabolism - cytochrome P450 0 0 0.438352638 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Drug metabolism - other enzymes 0 -0.480237154 0.565508366 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport EGFR tyrosine kinase inhibitor resistance 0 -0.630434783 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport ErbB signaling pathway 0 0.472332016 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Fanconi anemia pathway 0.49826087 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Fatty acid degradation 0 0.472332016 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Folate biosynthesis 0.525217391 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport FoxO signaling pathway 0 0.637351779 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Fructose and mannose metabolism 0 0.60770751 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Galactose metabolism 0 0.500988142 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Glutathione metabolism 0 -0.621541502 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Glycerolipid metabolism 0.606086957 0.748023715 0.468983269 kegg kegg NA NA no no no no no up SNARE interactions in vesicular transport Glycerophospholipid metabolism 0.435652174 0.671936759 0.448133848 kegg kegg NA NA no no no no no up SNARE interactions in vesicular transport "Glycine, serine and threonine metabolism" 0 0 -0.406692407 kegg kegg NA NA no no no no up no SNARE interactions in vesicular transport Glycolysis / Gluconeogenesis 0 -0.614624506 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.658102767 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.417760618 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Glycosaminoglycan biosynthesis - keratan sulfate -0.423478261 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Glycosaminoglycan degradation 0 0 0.41981982 kegg kegg NA NA no no no no no up SNARE interactions in vesicular transport Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.488142292 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport HIF-1 signaling pathway 0 -0.679841897 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Histidine metabolism 0.477391304 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Homologous recombination 0.52 0.416007905 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Inositol phosphate metabolism 0.467826087 0.64229249 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Lysine degradation 0.451304348 0.451581028 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Mannose type O-glycan biosynthesis 0 0.416007905 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport MAPK signaling pathway 0 0.579051383 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Mucin type O-glycan biosynthesis 0 0.540513834 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport NF-kappa B signaling pathway 0.604347826 0.752964427 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Oocyte meiosis 0 -0.446640316 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Other glycan degradation 0.744347826 0.874505929 0.533333333 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Other types of O-glycan biosynthesis 0.449565217 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Oxidative phosphorylation 0 -0.688735178 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport p53 signaling pathway 0 0.568181818 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Pantothenate and CoA biosynthesis 0 0.463438735 0 kegg kegg NA NA no no no no no dn SNARE interactions in vesicular transport Phospholipase D signaling pathway 0 0.539525692 0 kegg kegg NA NA no no no no up up SNARE interactions in vesicular transport Platinum drug resistance 0 0.538537549 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Propanoate metabolism 0 -0.540513834 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Proteasome 0 -0.421936759 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Protein export 0 -0.460474308 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Pyrimidine metabolism 0 0 0.603603604 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Pyruvate metabolism 0 -0.540513834 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Rap1 signaling pathway -0.448695652 -0.577075099 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Ribosome 0 -0.760869565 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport RNA transport 0 -0.524703557 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Selenocompound metabolism 0.409565217 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Spliceosome 0 0.567193676 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Starch and sucrose metabolism 0 0.507905138 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Taurine and hypotaurine metabolism 0.565217391 0.600790514 0.62960103 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Thiamine metabolism 0.530434783 -0.419960474 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Tyrosine metabolism 0 -0.451581028 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Ubiquinone and other terpenoid-quinone biosynthesis 0.413043478 0 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Ubiquitin mediated proteolysis 0 -0.533596838 0 kegg kegg NA NA no no no no no no SNARE interactions in vesicular transport Viral protein interaction with cytokine and cytokine receptor -0.520869565 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism alpha-Linolenic acid metabolism 0 0 0.588931789 kegg kegg NA NA no no no no no no Sphingolipid metabolism Amino sugar and nucleotide sugar metabolism 0 0 0.483912484 kegg kegg NA NA no no no no no no Sphingolipid metabolism Ascorbate and aldarate metabolism 0 0.540513834 0.569369369 kegg kegg NA NA no no no no no no Sphingolipid metabolism Cysteine and methionine metabolism -0.593043478 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Fructose and mannose metabolism 0 0 0.590733591 kegg kegg NA NA no no no no no no Sphingolipid metabolism Galactose metabolism 0 0 0.731531532 kegg kegg NA NA no no no no no no Sphingolipid metabolism "Glycine, serine and threonine metabolism" 0 0 -0.418532819 kegg kegg NA NA no no no no up no Sphingolipid metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.58 0 0.541570142 kegg kegg NA NA no no no no no no Sphingolipid metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.548777349 kegg kegg NA NA no no no no no no Sphingolipid metabolism Glycosaminoglycan degradation 0.843478261 0.566205534 0.751866152 kegg kegg NA NA no no no no no up Sphingolipid metabolism Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.637391304 -0.54743083 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Histidine metabolism 0 0 0.510939511 kegg kegg NA NA no no no no no no Sphingolipid metabolism N-Glycan biosynthesis -0.550434783 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Other glycan degradation 0 0 0.574259974 kegg kegg NA NA no no no no no no Sphingolipid metabolism Other types of O-glycan biosynthesis -0.483478261 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Pentose phosphate pathway 0.637391304 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Selenocompound metabolism -0.406086957 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Starch and sucrose metabolism 0 0 0.684684685 kegg kegg NA NA no no no no no no Sphingolipid metabolism Steroid biosynthesis -0.46173913 0 0 kegg kegg NA NA no no no no no no Sphingolipid metabolism Steroid hormone biosynthesis 0 0 0.403088803 kegg kegg NA NA no no no no no no Sphingolipid metabolism Synthesis and degradation of ketone bodies -0.585217391 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway 2-Oxocarboxylic acid metabolism -0.706086957 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway ABC transporters -0.479130435 0 0 kegg kegg NA NA no no no no up up Sphingolipid signaling pathway alpha-Linolenic acid metabolism -0.428695652 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Amino sugar and nucleotide sugar metabolism -0.602608696 -0.546442688 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Aminoacyl-tRNA biosynthesis -0.631304348 -0.553359684 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Antifolate resistance -0.570434783 -0.519762846 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Arachidonic acid metabolism -0.586956522 0 -0.625997426 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Arginine and proline metabolism 0 0.436758893 0 kegg kegg NA NA no no no no up no Sphingolipid signaling pathway Basal transcription factors 0 -0.463438735 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Base excision repair 0 -0.526679842 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway beta-Alanine metabolism -0.673913043 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Biosynthesis of amino acids 0 0.533596838 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Biosynthesis of cofactors -0.794782609 -0.734189723 -0.695495495 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Biosynthesis of unsaturated fatty acids -0.499130435 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Butanoate metabolism -0.774782609 -0.485177866 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Butyricimonas 0.55503849 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Sphingolipid signaling pathway Calcium signaling pathway 0.545217391 0 0 kegg kegg NA NA no no no no up up Sphingolipid signaling pathway cAMP signaling pathway 0.735652174 0.421936759 0 yes kegg kegg NA NA no no no no up up Sphingolipid signaling pathway Carbon metabolism -0.536521739 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway cGMP-PKG signaling pathway 0.728695652 0.571146245 0.487258687 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Chemokine signaling pathway 0.539130435 0.549407115 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Citrate cycle (TCA cycle) -0.56 -0.473320158 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Cytokine-cytokine receptor interaction 0.425217391 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway DNA replication -0.408695652 -0.601778656 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Drug metabolism - cytochrome P450 0 -0.536561265 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Drug metabolism - other enzymes -0.537391304 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Endocrine resistance 0 -0.460474308 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway ErbB signaling pathway 0.626956522 0 0.65045045 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Ether lipid metabolism 0 -0.550395257 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Fanconi anemia pathway 0 -0.635375494 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Fatty acid elongation -0.482608696 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway FoxO signaling pathway 0.433913043 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Fructose and mannose metabolism -0.673043478 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Galactose metabolism -0.565217391 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Glutathione metabolism -0.529565217 -0.473320158 -0.750836551 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway "Glycine, serine and threonine metabolism" -0.61826087 -0.658102767 -0.654311454 kegg kegg NA NA no no no no up no Sphingolipid signaling pathway Glycolysis / Gluconeogenesis -0.646086957 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0 0.48957529 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.47979408 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.420849421 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Glycosaminoglycan degradation 0 0.429841897 0.508622909 kegg kegg NA NA no no no no no up Sphingolipid signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 -0.453557312 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.430434783 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.697628458 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Histidine metabolism -0.454782609 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Homologous recombination 0 -0.557312253 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Inositol phosphate metabolism 0 0 0.485456885 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Linoleic acid metabolism 0 -0.446640316 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway MAPK signaling pathway 0 0 0.686743887 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.470355731 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Mismatch repair -0.54 -0.623517787 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway mRNA surveillance pathway 0.431304348 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway NF-kappa B signaling pathway 0 0.414031621 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Nicotinate and nicotinamide metabolism 0 0.444664032 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Non-homologous end-joining -0.611304348 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Nucleotide excision repair 0 -0.683794466 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway One carbon pool by folate -0.416521739 -0.673913043 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Other glycan degradation 0 0 0.435521236 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Other types of O-glycan biosynthesis 0 -0.420948617 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Oxidative phosphorylation 0.409565217 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Pentose and glucuronate interconversions -0.503478261 -0.464426877 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Pentose phosphate pathway 0 0.584980237 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Phenylalanine metabolism -0.610434783 -0.464426877 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Phosphatidylinositol signaling system 0.542608696 0 0.499099099 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Porphyrin and chlorophyll metabolism -0.610434783 -0.632411067 -0.734105534 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway PPAR signaling pathway 0 0.634387352 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Primary bile acid biosynthesis -0.550434783 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Propanoate metabolism -0.446956522 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Purine metabolism -0.423478261 -0.622529644 -0.546718147 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Pyrimidine metabolism -0.565217391 -0.588932806 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Pyruvate metabolism -0.519130435 -0.499011858 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Ras signaling pathway 0.520869565 0 0.483912484 yes kegg kegg NA NA no no no no up up Sphingolipid signaling pathway Retinol metabolism 0 -0.677865613 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Ribosome biogenesis in eukaryotes 0 -0.581027668 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway RNA degradation 0.423478261 0 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway RNA polymerase 0 -0.602766798 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Selenocompound metabolism 0 -0.493083004 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Sphingolipid metabolism 0 0 0.511454311 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Steroid biosynthesis 0 -0.518774704 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Steroid hormone biosynthesis -0.487826087 -0.555335968 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Sulfur metabolism -0.582608696 0 -0.647104247 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Synthesis and degradation of ketone bodies -0.466956522 -0.619565217 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Thiamine metabolism -0.468695652 -0.414031621 -0.414929215 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Tryptophan metabolism -0.670434783 0 0 kegg kegg NA NA no no no no up no Sphingolipid signaling pathway Tyrosine metabolism -0.587826087 -0.627470356 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.66173913 -0.658102767 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway "Valine, leucine and isoleucine degradation" -0.68 -0.596837945 0 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Various types of N-glycan biosynthesis 0 0 0.40952381 kegg kegg NA NA no no no no no no Sphingolipid signaling pathway Viral protein interaction with cytokine and cytokine receptor 0.448695652 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia 2-Oxocarboxylic acid metabolism -0.436521739 0.597826087 0.496782497 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Adherens junction -0.756521739 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Adipocytokine signaling pathway 0 0 -0.579150579 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Adrenergic signaling in cardiomyocytes 0.464347826 0 0 kegg kegg NA NA no no no no no up Spinocerebellar ataxia AGE-RAGE signaling pathway in diabetic complications 0 -0.443675889 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia "Alanine, aspartate and glutamate metabolism" 0 -0.498023715 -0.427799228 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Aldosterone synthesis and secretion 0 0.432806324 0 kegg kegg NA NA no no no no up up Spinocerebellar ataxia Aldosterone-regulated sodium reabsorption 0.62173913 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia alpha-Linolenic acid metabolism -0.47826087 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Alzheimer disease 0.475652174 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Amino sugar and nucleotide sugar metabolism -0.520869565 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Aminoacyl-tRNA biosynthesis 0 0.653162055 0.504761905 kegg kegg NA NA no no no no no no Spinocerebellar ataxia AMPK signaling pathway 0 0.429841897 -0.529214929 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Antifolate resistance 0 0.542490119 0.401287001 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Apelin signaling pathway 0.527826087 0 0.585328185 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Apoptosis -0.552173913 -0.5 -0.518918919 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Apoptosis - multiple species 0.455652174 0.41798419 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Arachidonic acid metabolism -0.486956522 -0.502964427 -0.720978121 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Arginine and proline metabolism 0 -0.644268775 0 kegg kegg NA NA no no no no up no Spinocerebellar ataxia Arginine biosynthesis 0 -0.565217391 -0.533333333 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Ascorbate and aldarate metabolism 0 0 0.622908623 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Autophagy - animal 0.68 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Autophagy - other 0.866956522 0 0.723294723 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Axon guidance 0.571304348 0 0 kegg kegg NA NA no no no no up up Spinocerebellar ataxia B cell receptor signaling pathway 0 -0.491106719 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Basal transcription factors 0.671304348 0.7243083 0.826769627 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Base excision repair 0.439130435 0.703557312 0.621621622 kegg kegg NA NA no no no no no no Spinocerebellar ataxia beta-Alanine metabolism -0.653043478 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Bile secretion 0 0 -0.656370656 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Biosynthesis of amino acids -0.555652174 -0.608695652 -0.55032175 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Biosynthesis of cofactors -0.413913043 0 -0.68957529 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Butanoate metabolism 0 0.454545455 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Butyricimonas 0.440738966 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Spinocerebellar ataxia C-type lectin receptor signaling pathway 0.56 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Calcium signaling pathway 0.500869565 0 0 kegg kegg NA NA no no no no up up Spinocerebellar ataxia cAMP signaling pathway 0.527826087 -0.447628458 0 yes kegg kegg NA NA no no no no up up Spinocerebellar ataxia Carbohydrate digestion and absorption 0.594782609 0 0.457400257 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Carbon metabolism -0.568695652 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Cell cycle 0.416521739 0.834980237 0.715315315 kegg kegg NA NA no no no no no no Spinocerebellar ataxia cGMP-PKG signaling pathway 0 -0.729249012 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Chemokine signaling pathway 0 -0.666007905 -0.459202059 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Cholinergic synapse 0.531304348 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Circadian entrainment 0 0 -0.483140283 kegg kegg NA NA no no no no up up Spinocerebellar ataxia Circadian rhythm 0.850434783 0.837944664 0.738738739 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Citrate cycle (TCA cycle) 0 0.433794466 0.715572716 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Collecting duct acid secretion 0 -0.524703557 -0.46048906 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Collinsella 0 0 -0.44443225 kegg Genus NA 0.128 no no no no no no Spinocerebellar ataxia Complement and coagulation cascades -0.495652174 -0.699604743 -0.584041184 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Cushing syndrome 0 0.455533597 0 kegg kegg NA NA no no no no no up Spinocerebellar ataxia Cysteine and methionine metabolism 0 0.456521739 0.453024453 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Cytokine-cytokine receptor interaction 0 -0.544466403 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia DNA replication 0 0.677865613 0.727413127 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Drug metabolism - cytochrome P450 0 0.418972332 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Drug metabolism - other enzymes -0.492173913 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia EGFR tyrosine kinase inhibitor resistance 0.546956522 0.449604743 0.507850708 kegg kegg NA NA no no no no no no Spinocerebellar ataxia ErbB signaling pathway 0.556521739 0 0.491377091 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Estrogen signaling pathway 0 0.438735178 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Ether lipid metabolism 0 0 0.502445302 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Fanconi anemia pathway 0 0.718379447 0.6998713 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Fat digestion and absorption 0 -0.62055336 0 yes kegg kegg NA NA no no no no up up Spinocerebellar ataxia Fatty acid biosynthesis 0 -0.485177866 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Fatty acid elongation -0.54173913 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Fc epsilon RI signaling pathway 0 -0.46541502 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Fc gamma R-mediated phagocytosis 0 -0.622529644 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Ferroptosis 0 -0.437747036 -0.592792793 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Focal adhesion -0.720869565 0 0 kegg kegg NA NA no no no no up up Spinocerebellar ataxia Folate biosynthesis 0 0.612648221 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Fructose and mannose metabolism -0.576521739 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia GABAergic synapse 0 -0.576086957 -0.428056628 kegg kegg NA NA no no no no up up Spinocerebellar ataxia Galactose metabolism -0.684347826 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Gap junction 0 0 -0.721492921 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Gastric acid secretion -0.72 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Glucagon signaling pathway 0 0.562252964 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Glutamatergic synapse 0 0 -0.700900901 kegg kegg NA NA no no no no up up Spinocerebellar ataxia Glutathione metabolism 0 0 -0.683140283 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Glycerolipid metabolism 0 0 0.65997426 kegg kegg NA NA no no no no no up Spinocerebellar ataxia Glycerophospholipid metabolism 0 0 0.735392535 kegg kegg NA NA no no no no no up Spinocerebellar ataxia "Glycine, serine and threonine metabolism" 0 0 -0.733848134 kegg kegg NA NA no no no no up no Spinocerebellar ataxia Glycolysis / Gluconeogenesis -0.483478261 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.475652174 0.611660079 0.621879022 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Glycosaminoglycan biosynthesis - keratan sulfate 0 0.508893281 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Glycosaminoglycan degradation 0 -0.497035573 0.438610039 kegg kegg NA NA no no no no no up Spinocerebellar ataxia Glycosphingolipid biosynthesis - ganglio series 0 0.575098814 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Glyoxylate and dicarboxylate metabolism 0 -0.565217391 -0.442471042 kegg kegg NA NA no no no no no no Spinocerebellar ataxia GnRH secretion 0.553043478 0 0.568597169 kegg kegg NA NA no no no no up up Spinocerebellar ataxia Hedgehog signaling pathway 0 0.847826087 0.706563707 kegg kegg NA NA no no no no no no Spinocerebellar ataxia HIF-1 signaling pathway 0.542608696 0 0.472329472 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Hippo signaling pathway -0.690434783 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Hippo signaling pathway - multiple species 0 -0.464426877 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Histidine metabolism -0.489565217 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Homologous recombination 0 0.554347826 0.55032175 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Huntington disease 0.456521739 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia IL-17 signaling pathway 0 -0.738142292 -0.403603604 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Inositol phosphate metabolism 0 0.431818182 0.614414414 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Insulin resistance 0.723478261 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Insulin signaling pathway 0.580869565 0.425889328 0.628571429 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Leukocyte transendothelial migration -0.56 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Linoleic acid metabolism 0 0 0.405148005 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Long-term depression 0 0 -0.566280566 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Long-term potentiation 0.651304348 0 0.628314028 kegg kegg NA NA no no no no no up Spinocerebellar ataxia Longevity regulating pathway 0 0 -0.487516088 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Lysine degradation 0.463478261 0.743083004 0.776833977 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Lysosome 0 -0.688735178 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Mannose type O-glycan biosynthesis 0.426956522 0.659090909 0.695238095 kegg kegg NA NA no no no no no no Spinocerebellar ataxia MAPK signaling pathway 0 0 0.48983269 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Mineral absorption 0 0 -0.472586873 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Mismatch repair 0 0.473320158 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia mRNA surveillance pathway 0.692173913 0.732213439 0.728185328 kegg kegg NA NA no no no no no no Spinocerebellar ataxia mTOR signaling pathway 0.509565217 0.423913043 0.477477477 kegg kegg NA NA no no no no no no Spinocerebellar ataxia N-Glycan biosynthesis 0.41826087 0.723320158 0.647876448 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Necroptosis 0 0 -0.532818533 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Neuroactive ligand-receptor interaction 0 -0.616600791 0 kegg kegg NA NA no no no up up up Spinocerebellar ataxia Neurotrophin signaling pathway 0.593913043 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Neutrophil extracellular trap formation -0.509565217 -0.711462451 -0.576833977 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Nicotinate and nicotinamide metabolism 0 -0.591897233 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Nitrogen metabolism 0 -0.618577075 -0.602831403 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Non-alcoholic fatty liver disease 0.484347826 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Non-homologous end-joining -0.405217391 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Notch signaling pathway 0 0 0.686743887 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Nucleotide excision repair 0 0.622529644 0.549034749 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Olfactory transduction 0 -0.743083004 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia One carbon pool by folate 0 0.636363636 0.641698842 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Oocyte meiosis 0.557391304 0 0.631917632 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Osteoclast differentiation 0 -0.539525692 -0.405920206 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Other glycan degradation 0 0 0.552638353 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Other types of O-glycan biosynthesis 0.522608696 0.644268775 0.715830116 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Ovarian steroidogenesis 0 0 -0.666666667 kegg kegg NA NA no no no no up up Spinocerebellar ataxia Oxytocin signaling pathway -0.770434783 -0.43083004 -0.644787645 kegg kegg NA NA no no no no no no Spinocerebellar ataxia p53 signaling pathway 0.616521739 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Pantothenate and CoA biosynthesis 0 -0.587944664 0 kegg kegg NA NA no no no no no dn Spinocerebellar ataxia "Parathyroid hormone synthesis, secretion and action" 0.440869565 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Pentose and glucuronate interconversions 0 0.559288538 0.565250965 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Pentose phosphate pathway -0.532173913 -0.701581028 -0.490604891 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Peroxisome 0 -0.491106719 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Phagosome -0.556521739 -0.506916996 -0.467181467 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Phenylalanine metabolism -0.673913043 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Phosphatidylinositol signaling system 0.669565217 0.726284585 0.74980695 kegg kegg NA NA no no no no no no Spinocerebellar ataxia PI3K-Akt signaling pathway 0 0.422924901 0.622651223 yes kegg kegg NA NA no no no no up up Spinocerebellar ataxia Platelet activation -0.786086957 0 -0.426254826 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Platinum drug resistance 0.523478261 0.585968379 0.414157014 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Porphyrin and chlorophyll metabolism 0 0 -0.711969112 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Progesterone-mediated oocyte maturation 0.674782609 0.677865613 0.827027027 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Propanoate metabolism 0 0 0.447361647 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Proteasome 0.62 0 0.463577864 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Protein export 0.737391304 0.46541502 0.718661519 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Protein processing in endoplasmic reticulum 0 0.659090909 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Proximal tubule bicarbonate reclamation 0 0.537549407 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Pyrimidine metabolism -0.431304348 0.431818182 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Pyruvate metabolism 0 0.451581028 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Rap1 signaling pathway -0.619130435 0 -0.415186615 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Ras signaling pathway 0.414782609 0.444664032 0.624453024 yes kegg kegg NA NA no no no no up up Spinocerebellar ataxia Regulation of actin cytoskeleton -0.546086957 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Regulation of lipolysis in adipocytes 0 0 -0.492921493 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Renin secretion 0 0 -0.411840412 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Renin-angiotensin system 0 -0.593873518 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Retinol metabolism 0 0 0.56988417 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Retrograde endocannabinoid signaling 0 0 0.405405405 kegg kegg NA NA no no no no no up Spinocerebellar ataxia Ribosome 0.537391304 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Ribosome biogenesis in eukaryotes 0.526956522 0.859683794 0.814414414 kegg kegg NA NA no no no no no no Spinocerebellar ataxia RIG-I-like receptor signaling pathway 0.506956522 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia RNA degradation 0.710434783 0.713438735 0.857142857 kegg kegg NA NA no no no no no no Spinocerebellar ataxia RNA polymerase 0.634782609 0.802371542 0.702187902 kegg kegg NA NA no no no no no no Spinocerebellar ataxia RNA transport 0 0.473320158 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Salivary secretion 0 0 -0.586615187 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Selenocompound metabolism 0.49826087 0.593873518 0.676705277 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Serotonergic synapse 0 -0.5256917 -0.82960103 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Signaling pathways regulating pluripotency of stem cells 0.63826087 0.638339921 0.59047619 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Sphingolipid signaling pathway 0.526086957 0 0.486229086 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Spliceosome 0.597391304 0.668972332 0.695752896 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Starch and sucrose metabolism -0.454782609 -0.432806324 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Steroid biosynthesis 0 0 0.477477477 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Steroid hormone biosynthesis -0.442608696 0 0.433976834 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Sulfur metabolism -0.52 0 -0.697812098 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Synaptic vesicle cycle 0 -0.709486166 0 kegg kegg NA NA no no no no up up Spinocerebellar ataxia Synthesis and degradation of ketone bodies 0 0.568181818 0.578120978 kegg kegg NA NA no no no no no no Spinocerebellar ataxia T cell receptor signaling pathway 0.473043478 0 0.516344916 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Taste transduction 0 0.571146245 0.718661519 kegg kegg NA NA no no no no no up Spinocerebellar ataxia Taurine and hypotaurine metabolism 0 0 0.442213642 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Terpenoid backbone biosynthesis 0.467826087 0.502964427 0.76010296 kegg kegg NA NA no no no no no no Spinocerebellar ataxia TGF-beta signaling pathway 0.431304348 0 0.583268983 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Thyroid hormone signaling pathway -0.610434783 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Thyroid hormone synthesis 0 0 -0.645302445 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Tight junction -0.72173913 0 -0.404890605 kegg kegg NA NA no no no no no no Spinocerebellar ataxia TNF signaling pathway 0.568695652 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Toll-like receptor signaling pathway 0 -0.53458498 0 yes kegg kegg NA NA no no no no no no Spinocerebellar ataxia Tryptophan metabolism -0.41826087 0 0.487516088 kegg kegg NA NA no no no no up no Spinocerebellar ataxia Type II diabetes mellitus 0.592173913 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Tyrosine metabolism -0.489565217 0 0 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Ubiquinone and other terpenoid-quinone biosynthesis 0 0.446640316 0.521235521 kegg kegg NA NA no no no no no no Spinocerebellar ataxia "Valine, leucine and isoleucine degradation" 0 0.451581028 0.515830116 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Various types of N-glycan biosynthesis 0.590434783 0.741106719 0.706048906 kegg kegg NA NA no no no no no no Spinocerebellar ataxia VEGF signaling pathway 0.54173913 0 0.533590734 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Viral protein interaction with cytokine and cytokine receptor 0 -0.768774704 -0.403603604 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Vitamin digestion and absorption 0 0 0.526383526 kegg kegg NA NA no no no no no no Spinocerebellar ataxia Wnt signaling pathway 0 0.739130435 0.772972973 kegg kegg NA NA no no no no no no Spliceosome ABC transporters 0.424347826 0.789525692 0 kegg kegg NA NA no no no no up up Spliceosome Amino sugar and nucleotide sugar metabolism 0 0.437747036 0 kegg kegg NA NA no no no no no no Spliceosome Aminoacyl-tRNA biosynthesis 0.490434783 0.564229249 0.55006435 kegg kegg NA NA no no no no no no Spliceosome Anaerostipes 0 0.532543849 0 butyrate-producing kegg Genus NA 0.568 no no no no no no Spliceosome Antifolate resistance 0 0.45256917 0 kegg kegg NA NA no no no no no no Spliceosome Arachidonic acid metabolism 0 0 -0.661776062 kegg kegg NA NA no no no no no no Spliceosome Arginine biosynthesis 0 0 -0.542342342 kegg kegg NA NA no no no no no no Spliceosome Basal transcription factors 0.794782609 0.625494071 0.791505792 kegg kegg NA NA no no no no no no Spliceosome Biosynthesis of amino acids 0 0 -0.693178893 kegg kegg NA NA no no no no no no Spliceosome Carbon metabolism 0 -0.574110672 -0.511969112 kegg kegg NA NA no no no no no no Spliceosome Citrate cycle (TCA cycle) 0 0 0.410810811 kegg kegg NA NA no no no no no no Spliceosome Cysteine and methionine metabolism 0.485217391 0 0.61981982 kegg kegg NA NA no no no no no no Spliceosome DNA replication 0.665217391 0 0.623423423 kegg kegg NA NA no no no no no no Spliceosome EGFR tyrosine kinase inhibitor resistance 0.617391304 0 0.484684685 kegg kegg NA NA no no no no no no Spliceosome Glutathione metabolism 0 0 -0.482625483 kegg kegg NA NA no no no no no no Spliceosome Glycerolipid metabolism 0 0.683794466 0.464092664 kegg kegg NA NA no no no no no up Spliceosome Glycerophospholipid metabolism 0 0.716403162 0.614414414 kegg kegg NA NA no no no no no up Spliceosome Glycosaminoglycan degradation -0.64173913 0 0 kegg kegg NA NA no no no no no up Spliceosome Glycosphingolipid biosynthesis - ganglio series 0 0.447628458 0 kegg kegg NA NA no no no no no no Spliceosome Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.626956522 0.548418972 0 kegg kegg NA NA no no no no no no Spliceosome Glyoxylate and dicarboxylate metabolism 0 0 -0.56010296 kegg kegg NA NA no no no no no no Spliceosome Inositol phosphate metabolism 0 0.782608696 0.563449163 kegg kegg NA NA no no no no no no Spliceosome Lachnospira 0 -0.603904145 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Spliceosome Lysine degradation 0.707826087 0.884387352 0.745173745 kegg kegg NA NA no no no no no no Spliceosome Mannose type O-glycan biosynthesis 0 0.700592885 0.656628057 kegg kegg NA NA no no no no no no Spliceosome mRNA surveillance pathway 0 0.443675889 0.794337194 kegg kegg NA NA no no no no no no Spliceosome Mucin type O-glycan biosynthesis 0 0.621541502 0.433976834 kegg kegg NA NA no no no no no no Spliceosome N-Glycan biosynthesis 0.55826087 0 0.719433719 kegg kegg NA NA no no no no no no Spliceosome Nicotinate and nicotinamide metabolism 0 0 -0.512998713 kegg kegg NA NA no no no no no no Spliceosome Nitrogen metabolism 0 0 -0.522265122 kegg kegg NA NA no no no no no no Spliceosome One carbon pool by folate 0.553913043 0 0.621879022 kegg kegg NA NA no no no no no no Spliceosome Oscillospira 0 0.45256917 0 LPS-producing kegg Genus NA 0.62 no no no no no no Spliceosome Other glycan degradation 0 0.659090909 0 kegg kegg NA NA no no no no no no Spliceosome Other types of O-glycan biosynthesis 0.646086957 0.864624506 0.796396396 kegg kegg NA NA no no no no no no Spliceosome Parabacteroides 0 0 -0.487418754 kegg Genus NA 4.19E-05 no no no no up up Spliceosome Pentose and glucuronate interconversions 0 0 0.483655084 kegg kegg NA NA no no no no no no Spliceosome Pentose phosphate pathway -0.508695652 -0.589920949 -0.697297297 kegg kegg NA NA no no no no no no Spliceosome Platinum drug resistance 0.803478261 0.899209486 0.646332046 kegg kegg NA NA no no no no no no Spliceosome Propanoate metabolism 0.448695652 0 0.498841699 kegg kegg NA NA no no no no no no Spliceosome Pyruvate metabolism 0.443478261 0 0 kegg kegg NA NA no no no no no no Spliceosome Ribosome biogenesis in eukaryotes 0.855652174 0.657114625 0.86975547 kegg kegg NA NA no no no no no no Spliceosome RNA degradation 0 0 0.84015444 kegg kegg NA NA no no no no no no Spliceosome RNA polymerase 0.812173913 0.538537549 0.554440154 kegg kegg NA NA no no no no no no Spliceosome RNA transport 0.743478261 0 0.547490347 kegg kegg NA NA no no no no no no Spliceosome Roseburia -0.485217391 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no Spliceosome Selenocompound metabolism 0.740869565 0.793478261 0.662290862 kegg kegg NA NA no no no no no no Spliceosome Sphingolipid metabolism -0.653913043 0 0 kegg kegg NA NA no no no no no no Spliceosome Sulfur metabolism 0 0 -0.516087516 kegg kegg NA NA no no no no no no Spliceosome Synthesis and degradation of ketone bodies 0.476521739 0 0.519433719 kegg kegg NA NA no no no no no no Spliceosome Taurine and hypotaurine metabolism 0.431304348 0.670948617 0.429086229 kegg kegg NA NA no no no no no no Spliceosome Terpenoid backbone biosynthesis 0.597391304 0.468379447 0.564478764 kegg kegg NA NA no no no no no no Spliceosome Ubiquinone and other terpenoid-quinone biosynthesis 0 0 0.41029601 kegg kegg NA NA no no no no no no Spliceosome "Valine, leucine and isoleucine degradation" 0 0 0.40978121 kegg kegg NA NA no no no no no no Spliceosome Various types of N-glycan biosynthesis 0.645217391 0 0.718146718 kegg kegg NA NA no no no no no no Staphylococcus aureus infection Adrenergic signaling in cardiomyocytes -0.589565217 -0.621541502 -0.538738739 kegg kegg NA NA up no no no no up Staphylococcus aureus infection AGE-RAGE signaling pathway in diabetic complications 0 0.46541502 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection "Alanine, aspartate and glutamate metabolism" 0 0 0.490604891 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Aldosterone synthesis and secretion -0.562608696 -0.754940711 -0.484684685 kegg kegg NA NA up no no no up up Staphylococcus aureus infection alpha-Linolenic acid metabolism 0.426086957 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Alzheimer disease -0.588695652 -0.4743083 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Amoebiasis 0 0 0.61003861 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Amphetamine addiction -0.639130435 -0.73715415 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection AMPK signaling pathway 0 -0.782608696 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Amyotrophic lateral sclerosis -0.56 -0.524703557 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Antifolate resistance 0 -0.545454545 -0.440669241 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Antigen processing and presentation 0 0.503952569 0.563191763 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Apelin signaling pathway -0.589565217 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Apoptosis 0.555652174 0.611660079 0.657400257 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Arginine and proline metabolism 0 0.506916996 0.413384813 kegg kegg NA NA up no no no up no Staphylococcus aureus infection Arginine biosynthesis 0 0 0.577091377 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Autophagy - other -0.526956522 0 -0.584555985 kegg kegg NA NA up no no no no no Staphylococcus aureus infection B cell receptor signaling pathway 0 0.479249012 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Bacterial invasion of epithelial cells 0.52 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Basal transcription factors -0.415652174 -0.595849802 -0.684427284 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Base excision repair 0 -0.595849802 -0.455341055 kegg kegg NA NA up no no no no no Staphylococcus aureus infection beta-Alanine metabolism 0.606086957 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Biosynthesis of amino acids 0.652173913 0.711462451 0.843500644 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Biosynthesis of cofactors 0 -0.651185771 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection C-type lectin receptor signaling pathway 0 0.485177866 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Calcium signaling pathway -0.447826087 -0.48715415 -0.50990991 kegg kegg NA NA up no no no up up Staphylococcus aureus infection cAMP signaling pathway -0.583478261 0 0 yes kegg kegg NA NA up no no no up up Staphylococcus aureus infection Carbon metabolism 0.58173913 0.670948617 0.785585586 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Cardiac muscle contraction -0.494782609 -0.454545455 0 kegg kegg NA NA up no no no no up Staphylococcus aureus infection Cell adhesion molecules 0.602608696 0.77173913 0.506563707 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Cell cycle -0.445217391 -0.709486166 -0.703732304 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Cellular senescence 0 0.632411067 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection cGMP-PKG signaling pathway 0 0.774703557 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Chemokine signaling pathway 0 0.518774704 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Cholesterol metabolism 0 0.666007905 0 yes kegg kegg NA NA up no no no no up Staphylococcus aureus infection Circadian rhythm -0.657391304 -0.761857708 -0.809266409 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Clostridium 0 0.445217992 0 kegg Genus NA 0.925 up no no no no no Staphylococcus aureus infection Cocaine addiction -0.432173913 -0.721343874 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Collecting duct acid secretion 0 0 0.403088803 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Complement and coagulation cascades 0.528695652 0.755928854 0.781981982 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Cortisol synthesis and secretion -0.511304348 -0.788537549 0 kegg kegg NA NA up no no no no up Staphylococcus aureus infection Cushing syndrome -0.563478261 -0.875494071 -0.563449163 kegg kegg NA NA up no no no no up Staphylococcus aureus infection Cytokine-cytokine receptor interaction 0 0.414031621 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection DNA replication 0 -0.486166008 -0.568082368 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Dopaminergic synapse -0.651304348 -0.498023715 -0.439382239 kegg kegg NA NA up no no no up no Staphylococcus aureus infection Drug metabolism - other enzymes 0.432173913 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection EGFR tyrosine kinase inhibitor resistance -0.50173913 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Endocrine and other factor-regulated calcium reabsorption 0 -0.666007905 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Endocrine resistance -0.487826087 -0.671936759 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Endocytosis 0.453043478 0.769762846 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Epithelial cell signaling in Helicobacter pylori infection 0 0.623517787 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Ether lipid metabolism -0.468695652 -0.566205534 -0.514800515 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Faecalibacterium -0.405217391 0 0 butyrate-producing kegg Genus NA 0.0039 up no no no dn dn Staphylococcus aureus infection Fanconi anemia pathway 0 -0.606719368 -0.563449163 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Fat digestion and absorption 0 0.635375494 0.496782497 yes kegg kegg NA NA up no no no up up Staphylococcus aureus infection Fatty acid biosynthesis 0 0.453557312 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Fatty acid elongation 0.63826087 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Fatty acid metabolism 0.572173913 0.489130435 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Fc epsilon RI signaling pathway 0 0.589920949 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Fc gamma R-mediated phagocytosis 0.64 0.874505929 0.806177606 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Focal adhesion 0.419130435 0 0 kegg kegg NA NA up no no no up up Staphylococcus aureus infection GABAergic synapse 0 0 0.406949807 kegg kegg NA NA up no no no up up Staphylococcus aureus infection Galactose metabolism 0.633043478 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Gemmiger -0.417047194 0 0 butyrate-producing kegg Genus NA 0.595 up no no no no no Staphylococcus aureus infection Glucagon signaling pathway -0.693043478 -0.783596838 -0.657400257 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Glutathione metabolism 0 -0.577075099 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Glycerolipid metabolism 0 0 -0.503474903 kegg kegg NA NA up no no no no up Staphylococcus aureus infection Glycerophospholipid metabolism 0 0 -0.608494208 kegg kegg NA NA up no no no no up Staphylococcus aureus infection "Glycine, serine and threonine metabolism" 0 -0.621541502 0 kegg kegg NA NA up no no no up no Staphylococcus aureus infection Glycolysis / Gluconeogenesis 0 0 0.492664093 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Glycosaminoglycan biosynthesis - keratan sulfate 0 0 -0.570913771 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Glycosaminoglycan degradation 0 0.721343874 0 kegg kegg NA NA up no no no no up Staphylococcus aureus infection Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 -0.487258687 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.653162055 -0.484427284 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Glyoxylate and dicarboxylate metabolism 0.499130435 0.443675889 0.588159588 kegg kegg NA NA up no no no no no Staphylococcus aureus infection GnRH secretion 0 0 -0.409266409 kegg kegg NA NA up no no no up up Staphylococcus aureus infection GnRH signaling pathway -0.437391304 -0.66798419 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection "Growth hormone synthesis, secretion and action" -0.406086957 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Hedgehog signaling pathway 0 -0.593873518 -0.662290862 kegg kegg NA NA up no no no no no Staphylococcus aureus infection HIF-1 signaling pathway -0.443478261 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Homologous recombination 0 -0.503952569 -0.506048906 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Huntington disease -0.549565217 -0.498023715 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection IL-17 signaling pathway 0 0.792490119 0.595624196 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Inflammatory mediator regulation of TRP channels -0.51826087 -0.539525692 -0.429086229 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Inositol phosphate metabolism 0 0 -0.493693694 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Insulin resistance -0.484347826 0 -0.47001287 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Insulin secretion -0.413913043 -0.767786561 0 yes kegg kegg NA NA up no no no up up Staphylococcus aureus infection Insulin signaling pathway -0.58 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Intestinal immune network for IgA production 0 0 0.403861004 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Leishmaniasis 0 0 0.509395109 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Leukocyte transendothelial migration 0.474782609 0.532608696 0.638352638 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Long-term potentiation -0.55826087 0 -0.44015444 kegg kegg NA NA up no no no no up Staphylococcus aureus infection Longevity regulating pathway 0 -0.483201581 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Lysine degradation 0 -0.602766798 -0.699356499 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Lysosome 0.510434783 0.918972332 0.674646075 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Mannose type O-glycan biosynthesis 0 -0.472332016 -0.718404118 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Melanogenesis -0.422608696 -0.57312253 -0.418275418 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Mineral absorption -0.453913043 -0.481225296 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Mitophagy - animal -0.624347826 -0.593873518 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Morphine addiction 0 -0.584980237 0 kegg kegg NA NA up no no no up up Staphylococcus aureus infection mRNA surveillance pathway -0.590434783 -0.682806324 -0.841956242 kegg kegg NA NA up no no no no no Staphylococcus aureus infection mTOR signaling pathway -0.54 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection N-Glycan biosynthesis -0.426956522 -0.495059289 -0.54980695 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Natural killer cell mediated cytotoxicity 0.493913043 0.705533597 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Necroptosis -0.457391304 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Neuroactive ligand-receptor interaction 0.406956522 0.903162055 0.708622909 kegg kegg NA NA up no no up up up Staphylococcus aureus infection Neutrophil extracellular trap formation 0.707826087 0.852766798 0.855341055 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Nicotinate and nicotinamide metabolism 0 0.53458498 0.499099099 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Nicotine addiction 0 -0.484189723 0 kegg kegg NA NA up no no no up up Staphylococcus aureus infection Nitrogen metabolism 0 0 0.435263835 kegg kegg NA NA up no no no no no Staphylococcus aureus infection NOD-like receptor signaling pathway 0 0.502964427 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Non-alcoholic fatty liver disease -0.620869565 -0.480237154 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Notch signaling pathway 0 0 -0.553410553 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Nucleotide excision repair 0 -0.543478261 -0.482625483 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Olfactory transduction 0 0.739130435 0.614929215 kegg kegg NA NA up no no no no no Staphylococcus aureus infection One carbon pool by folate 0 -0.526679842 -0.533075933 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Oocyte meiosis -0.513913043 0 -0.450707851 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Osteoclast differentiation 0.475652174 0.736166008 0.598198198 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Other types of O-glycan biosynthesis -0.524347826 -0.668972332 -0.682882883 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Ovarian steroidogenesis 0 -0.5256917 0 kegg kegg NA NA up no no no up up Staphylococcus aureus infection Oxidative phosphorylation -0.52173913 -0.435770751 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Oxytocin signaling pathway 0 0 0.613384813 kegg kegg NA NA up no no no no no Staphylococcus aureus infection p53 signaling pathway -0.459130435 -0.515810277 -0.633976834 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Pancreatic secretion 0 -0.459486166 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Pantothenate and CoA biosynthesis 0 0.627470356 0.492406692 kegg kegg NA NA up no no no no dn Staphylococcus aureus infection "Parathyroid hormone synthesis, secretion and action" -0.726086957 -0.556324111 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Parkinson disease -0.635652174 -0.503952569 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Pathogenic Escherichia coli infection 0.56 0.792490119 0.715315315 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Pathways of neurodegeneration - multiple diseases -0.631304348 -0.545454545 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Pentose phosphate pathway 0.62173913 0.878458498 0.754182754 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Peroxisome 0.415652174 0.553359684 0.517631918 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Pertussis 0.62 0.841897233 0.848906049 kegg kegg NA NA up no no no no dn Staphylococcus aureus infection Phagosome 0.705217391 0.866600791 0.720720721 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Phosphatidylinositol signaling system -0.454782609 0 -0.737709138 kegg kegg NA NA up no no no no no Staphylococcus aureus infection PI3K-Akt signaling pathway -0.490434783 0 0 yes kegg kegg NA NA up no no no up up Staphylococcus aureus infection Platinum drug resistance 0 0 -0.42007722 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Porphyrin and chlorophyll metabolism 0 -0.595849802 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection PPAR signaling pathway 0 0.538537549 0.497039897 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Primary bile acid biosynthesis 0 0 0.483655084 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Prion disease -0.531304348 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Progesterone-mediated oocyte maturation -0.437391304 -0.437747036 -0.517374517 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Prolactin signaling pathway 0 0.429841897 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Protein digestion and absorption 0.527826087 0.608695652 0 yes kegg kegg NA NA up no no no up up Staphylococcus aureus infection Protein export -0.624347826 0 -0.56988417 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Protein processing in endoplasmic reticulum -0.480869565 -0.663043478 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Purine metabolism 0 -0.752964427 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Pyrimidine metabolism 0.422608696 -0.448616601 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Ras signaling pathway 0 0 -0.611840412 yes kegg kegg NA NA up no no no up up Staphylococcus aureus infection Regulation of lipolysis in adipocytes -0.472173913 -0.546442688 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Relaxin signaling pathway -0.550434783 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Renin secretion 0 -0.442687747 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Renin-angiotensin system 0.439130435 0.898221344 0.431145431 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Retrograde endocannabinoid signaling -0.409565217 0 0 kegg kegg NA NA up no no no no up Staphylococcus aureus infection Ribosome -0.723478261 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Ribosome biogenesis in eukaryotes -0.451304348 -0.668972332 -0.688545689 kegg kegg NA NA up no no no no no Staphylococcus aureus infection RNA degradation -0.50173913 -0.561264822 -0.691891892 kegg kegg NA NA up no no no no no Staphylococcus aureus infection RNA polymerase -0.548695652 -0.720355731 -0.58996139 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Salmonella infection 0.520869565 0.78458498 0.697812098 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Selenocompound metabolism 0 -0.522727273 -0.515572716 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Serotonergic synapse 0 0 0.42007722 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Shigellosis -0.459130435 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Signaling pathways regulating pluripotency of stem cells -0.566956522 -0.451581028 -0.625997426 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Sphingolipid signaling pathway 0 0.624505929 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Spinocerebellar ataxia -0.573043478 -0.563241107 -0.573487773 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Spliceosome -0.448695652 -0.510869565 -0.612612613 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Starch and sucrose metabolism 0 0.5 0.401544402 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Steroid biosynthesis -0.430434783 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Synaptic vesicle cycle 0 0.770750988 0.47979408 kegg kegg NA NA up no no no up up Staphylococcus aureus infection Taste transduction -0.412173913 -0.539525692 -0.597168597 kegg kegg NA NA up no no no no up Staphylococcus aureus infection Taurine and hypotaurine metabolism 0 0 -0.541312741 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Terpenoid backbone biosynthesis 0 0 -0.523294723 kegg kegg NA NA up no no no no no Staphylococcus aureus infection TGF-beta signaling pathway 0 0 -0.45045045 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Th1 and Th2 cell differentiation 0 0.441699605 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Thermogenesis -0.542608696 -0.460474308 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Thyroid hormone synthesis 0 -0.719367589 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Tight junction 0.42173913 0 0.577863578 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Toll-like receptor signaling pathway 0 0.517786561 0 yes kegg kegg NA NA up no no no no no Staphylococcus aureus infection Toxoplasmosis 0.46 0.684782609 0.555469755 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Type I diabetes mellitus 0.569565217 0.72826087 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Ubiquinone and other terpenoid-quinone biosynthesis 0 0 -0.482882883 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Ubiquitin mediated proteolysis -0.610434783 -0.68083004 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Various types of N-glycan biosynthesis -0.530434783 0 -0.401029601 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Vascular smooth muscle contraction -0.545217391 0 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Vasopressin-regulated water reabsorption -0.433043478 -0.577075099 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Viral protein interaction with cytokine and cytokine receptor 0 0.438735178 0 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Wnt signaling pathway 0 -0.567193676 -0.717374517 kegg kegg NA NA up no no no no no Staphylococcus aureus infection Yersinia infection 0.48173913 0.796442688 0.493436293 kegg kegg NA NA up no no no no no Starch and sucrose metabolism "Alanine, aspartate and glutamate metabolism" 0.584347826 0.828063241 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Arginine and proline metabolism 0.770434783 0.749011858 0.510682111 kegg kegg NA NA no no no no up no Starch and sucrose metabolism Arginine biosynthesis 0.672173913 0.776679842 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Ascorbate and aldarate metabolism 0 0 0.431145431 kegg kegg NA NA no no no no no no Starch and sucrose metabolism beta-Alanine metabolism 0.48 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Citrate cycle (TCA cycle) 0 -0.486166008 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Cysteine and methionine metabolism 0 -0.550395257 -0.435006435 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Fatty acid biosynthesis 0.555652174 0.897233202 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Fatty acid degradation 0.643478261 0.803359684 0.513256113 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Fructose and mannose metabolism 0.68173913 0.508893281 0.776833977 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Galactose metabolism 0.712173913 0.840909091 0.780952381 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Glutathione metabolism 0 -0.736166008 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism "Glycine, serine and threonine metabolism" 0 -0.445652174 0 kegg kegg NA NA no no no no up no Starch and sucrose metabolism Glycolysis / Gluconeogenesis 0.448695652 0 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Histidine metabolism 0.586086957 0.41798419 0.586615187 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Oxidative phosphorylation -0.44173913 -0.799407115 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Pentose and glucuronate interconversions 0 -0.644268775 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Pentose phosphate pathway 0.728695652 0.659090909 0.625482625 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Purine metabolism 0 -0.509881423 0 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Pyrimidine metabolism 0.473043478 -0.464426877 0.411840412 kegg kegg NA NA no no no no no no Starch and sucrose metabolism Steroid biosynthesis -0.435652174 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Ascorbate and aldarate metabolism 0 0.505928854 0.454826255 kegg kegg NA NA no no no no no no Steroid biosynthesis Citrate cycle (TCA cycle) 0 0.760869565 0.609266409 kegg kegg NA NA no no no no no no Steroid biosynthesis Fatty acid elongation 0 0.563241107 0.492664093 kegg kegg NA NA no no no no no no Steroid biosynthesis Glycolysis / Gluconeogenesis 0 0.540513834 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Pentose and glucuronate interconversions 0 0.649209486 0.498069498 kegg kegg NA NA no no no no no no Steroid biosynthesis Pentose phosphate pathway -0.633043478 0 0 kegg kegg NA NA no no no no no no Steroid biosynthesis Synthesis and degradation of ketone bodies 0.480869565 0.855731225 0.689060489 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Ascorbate and aldarate metabolism 0.622608696 0.584980237 0.609009009 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Citrate cycle (TCA cycle) 0.653043478 0.744071146 0.601544402 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Fatty acid elongation 0.736521739 0.606719368 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Fructose and mannose metabolism 0.439130435 0 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Galactose metabolism 0.486086957 0 0.533848134 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Glycolysis / Gluconeogenesis 0.613913043 0.511857708 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Pentose and glucuronate interconversions 0.74 0.664031621 0.429343629 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Primary bile acid biosynthesis 0.779130435 0.710474308 0 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Steroid biosynthesis 0 0.817193676 0.552123552 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Synthesis and degradation of ketone bodies 0.56 0.739130435 0.445559846 kegg kegg NA NA no no no no no no Steroid hormone biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis 0.705217391 0.789525692 0.537709138 kegg kegg NA NA no no no no no no Sulfur metabolism "Alanine, aspartate and glutamate metabolism" 0 0 0.491891892 kegg kegg NA NA no no no no no no Sulfur metabolism Amino sugar and nucleotide sugar metabolism 0.426956522 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Arachidonic acid metabolism 0.512173913 0 0.778120978 kegg kegg NA NA no no no no no no Sulfur metabolism Arginine biosynthesis 0 0 0.526640927 kegg kegg NA NA no no no no no no Sulfur metabolism beta-Alanine metabolism 0.53826087 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Butanoate metabolism 0.563478261 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Citrate cycle (TCA cycle) 0 0.459486166 0 kegg kegg NA NA no no no no no no Sulfur metabolism Fructose and mannose metabolism 0.471304348 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Glutathione metabolism 0.562608696 0.612648221 0.721750322 kegg kegg NA NA no no no no no no Sulfur metabolism Glycerolipid metabolism 0 0 -0.416216216 kegg kegg NA NA no no no no no up Sulfur metabolism Glycerophospholipid metabolism 0 0 -0.432689833 kegg kegg NA NA no no no no no up Sulfur metabolism "Glycine, serine and threonine metabolism" 0.530434783 0.609683794 0.755984556 kegg kegg NA NA no no no no up no Sulfur metabolism Glycolysis / Gluconeogenesis 0.426956522 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.592173913 0 -0.49009009 kegg kegg NA NA no no no no no no Sulfur metabolism Glycosaminoglycan biosynthesis - keratan sulfate 0 0 -0.422908623 kegg kegg NA NA no no no no no no Sulfur metabolism Glycosphingolipid biosynthesis - globo and isoglobo series 0 0 0.449163449 kegg kegg NA NA no no no no no no Sulfur metabolism Glyoxylate and dicarboxylate metabolism 0 0 0.466666667 kegg kegg NA NA no no no no no no Sulfur metabolism Lysine degradation 0 0 -0.506563707 kegg kegg NA NA no no no no no no Sulfur metabolism Mannose type O-glycan biosynthesis 0 0 -0.498584299 kegg kegg NA NA no no no no no no Sulfur metabolism N-Glycan biosynthesis 0 0 -0.562162162 kegg kegg NA NA no no no no no no Sulfur metabolism Nitrogen metabolism 0 0 0.586357786 kegg kegg NA NA no no no no no no Sulfur metabolism One carbon pool by folate 0 0 -0.430630631 kegg kegg NA NA no no no no no no Sulfur metabolism Other glycan degradation 0 0 -0.441184041 kegg kegg NA NA no no no no no no Sulfur metabolism Other types of O-glycan biosynthesis 0 0 -0.465894466 kegg kegg NA NA no no no no no no Sulfur metabolism Oxidative phosphorylation -0.41826087 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Pentose and glucuronate interconversions 0 0 -0.413899614 kegg kegg NA NA no no no no no no Sulfur metabolism Pentose phosphate pathway 0 0 0.540797941 kegg kegg NA NA no no no no no no Sulfur metabolism Phenylalanine metabolism 0.448695652 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Porphyrin and chlorophyll metabolism 0.565217391 0.644268775 0.782754183 kegg kegg NA NA no no no no no no Sulfur metabolism Purine metabolism 0.565217391 0.565217391 0.487001287 kegg kegg NA NA no no no no no no Sulfur metabolism Pyrimidine metabolism 0.416521739 0.553359684 0 kegg kegg NA NA no no no no no no Sulfur metabolism Pyruvate metabolism 0 0.447628458 0 kegg kegg NA NA no no no no no no Sulfur metabolism Steroid hormone biosynthesis 0.440869565 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Synthesis and degradation of ketone bodies 0 0.459486166 0 kegg kegg NA NA no no no no no no Sulfur metabolism Terpenoid backbone biosynthesis 0 0 -0.416988417 kegg kegg NA NA no no no no no no Sulfur metabolism Thiamine metabolism 0 0.541501976 0.416988417 kegg kegg NA NA no no no no no no Sulfur metabolism Tryptophan metabolism 0.487826087 0 0 kegg kegg NA NA no no no no up no Sulfur metabolism Tyrosine metabolism 0 0.424901186 0 kegg kegg NA NA no no no no no no Sulfur metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.440869565 0.415019763 0 kegg kegg NA NA no no no no no no Sulfur metabolism "Valine, leucine and isoleucine degradation" 0.430434783 0 0 kegg kegg NA NA no no no no no no Sulfur metabolism Various types of N-glycan biosynthesis 0 0 -0.606692407 kegg kegg NA NA no no no no no no Sutterella Bacteroides 0.448266836 0 0 LPS-producing Genus Genus 0.0582 0.000267 no no up dn dn up Synaptic vesicle cycle 2-Oxocarboxylic acid metabolism 0 -0.549407115 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Adrenergic signaling in cardiomyocytes 0 -0.700592885 -0.686486486 kegg kegg NA NA no up up no no up Synaptic vesicle cycle "Alanine, aspartate and glutamate metabolism" 0 0.68083004 0.463063063 kegg kegg NA NA no up up no no no Synaptic vesicle cycle alpha-Linolenic acid metabolism 0 0.493083004 0.456885457 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Amino sugar and nucleotide sugar metabolism 0 0 0.452509653 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Aminoacyl-tRNA biosynthesis 0 -0.437747036 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle AMPK signaling pathway -0.486086957 -0.599802372 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Antifolate resistance 0 -0.471343874 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Apelin signaling pathway 0 -0.496047431 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Apoptosis 0.419130435 0.565217391 0.532561133 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Arginine and proline metabolism 0.566956522 0.665019763 0.531788932 kegg kegg NA NA no up up no up no Synaptic vesicle cycle Arginine biosynthesis 0.45826087 0.714426877 0.48957529 kegg kegg NA NA no up up no no no Synaptic vesicle cycle B cell receptor signaling pathway 0 0.435770751 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Basal transcription factors 0 -0.589920949 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Base excision repair -0.526086957 -0.595849802 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Biosynthesis of amino acids 0 0.865612648 0.581981982 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Biosynthesis of cofactors -0.437391304 -0.489130435 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle C-type lectin receptor signaling pathway 0 0.416996047 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Calcium signaling pathway 0 -0.54743083 -0.625225225 kegg kegg NA NA no up up no up up Synaptic vesicle cycle Carbon metabolism 0 0.549407115 0.614671815 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Cardiac muscle contraction 0 -0.56027668 0 kegg kegg NA NA no up up no no up Synaptic vesicle cycle Cell adhesion molecules 0 0.536561265 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Cell cycle 0 -0.753952569 -0.618275418 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Cellular senescence 0 0.444664032 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle cGMP-PKG signaling pathway 0.7 0.886363636 0.415186615 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Chemokine signaling pathway 0 0.632411067 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Circadian rhythm 0 -0.807312253 -0.505534106 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Complement and coagulation cascades 0 0.853754941 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Cysteine and methionine metabolism 0 0 -0.446589447 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Cytokine-cytokine receptor interaction 0 0.665019763 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle DNA replication 0 -0.583992095 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Drug metabolism - other enzymes 0 0 0.46048906 kegg kegg NA NA no up up no no no Synaptic vesicle cycle ECM-receptor interaction -0.834782609 0 -0.567310167 kegg kegg NA NA no up up no up up Synaptic vesicle cycle EGFR tyrosine kinase inhibitor resistance 0 -0.483201581 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Endocrine resistance 0 -0.455533597 -0.47953668 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Endocytosis 0 0.575098814 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Ether lipid metabolism 0 -0.600790514 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Fanconi anemia pathway 0 -0.519762846 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Fatty acid biosynthesis 0.474782609 0.73715415 0.488030888 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Fatty acid degradation 0 0.574110672 0.52998713 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Fatty acid metabolism 0 0.683794466 0.454826255 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Fc epsilon RI signaling pathway 0.426956522 0.648221344 0.552123552 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Fc gamma R-mediated phagocytosis 0.554782609 0.89229249 0.499099099 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Folate biosynthesis 0 -0.584980237 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Fructose and mannose metabolism 0 0 0.668468468 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Galactose metabolism 0 0.466403162 0.481081081 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Glutathione metabolism 0 -0.447628458 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle "Glycine, serine and threonine metabolism" -0.50173913 0 0 kegg kegg NA NA no up up no up no Synaptic vesicle cycle Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.553913043 0 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.503952569 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Glycosaminoglycan biosynthesis - keratan sulfate 0 -0.610671937 -0.427027027 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Glycosaminoglycan degradation 0.570434783 0.587944664 0.458687259 kegg kegg NA NA no up up no no up Synaptic vesicle cycle Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.491106719 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Glyoxylate and dicarboxylate metabolism 0 0.732213439 0.569369369 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Hedgehog signaling pathway 0 -0.609683794 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Hippo signaling pathway - multiple species 0.547826087 0.432806324 0.498326898 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Histidine metabolism 0 0 0.496267696 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Homologous recombination 0 0 -0.427027027 kegg kegg NA NA no up up no no no Synaptic vesicle cycle IL-17 signaling pathway 0.605217391 0.871541502 0.679279279 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Lysine degradation -0.424347826 -0.710474308 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Lysosome 0.679130435 0.82312253 0.837580438 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Mannose type O-glycan biosynthesis 0 -0.703557312 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Mitophagy - animal 0 -0.479249012 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle mRNA surveillance pathway 0 -0.907114625 -0.532046332 kegg kegg NA NA no up up no no no Synaptic vesicle cycle mTOR signaling pathway 0 -0.490118577 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle N-Glycan biosynthesis -0.533913043 -0.721343874 -0.547490347 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Natural killer cell mediated cytotoxicity 0 0.527667984 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Neuroactive ligand-receptor interaction 0.526956522 0.798418972 0.698326898 kegg kegg NA NA no up up up up up Synaptic vesicle cycle Neutrophil extracellular trap formation 0.589565217 0.904150198 0.601544402 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Nicotinate and nicotinamide metabolism 0.657391304 0.776679842 0.661776062 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Nitrogen metabolism 0.417391304 0.643280632 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle NOD-like receptor signaling pathway 0.563478261 0.490118577 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Notch signaling pathway 0.462608696 0 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Nucleotide excision repair 0 -0.51284585 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle One carbon pool by folate 0 -0.524703557 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Oocyte meiosis 0 0 -0.577348777 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Osteoclast differentiation 0.673913043 0.744071146 0.582754183 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Other types of O-glycan biosynthesis 0 -0.669960474 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Oxidative phosphorylation 0 -0.52173913 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Pantothenate and CoA biosynthesis 0.617391304 0.781620553 0.717117117 kegg kegg NA NA no up up no no dn Synaptic vesicle cycle Pentose and glucuronate interconversions 0 -0.588932806 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Pentose phosphate pathway 0 0.931818182 0.793564994 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Peroxisome 0.463478261 0.751976285 0.44993565 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Phagosome 0 0.722332016 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Phosphatidylinositol signaling system 0 -0.443675889 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Porphyrin and chlorophyll metabolism -0.445217391 0 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle PPAR signaling pathway 0 0.622529644 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Proteasome 0 0 0.456370656 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Protein export 0 -0.586956522 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Protein processing in endoplasmic reticulum -0.607826087 -0.795454545 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Purine metabolism -0.432173913 -0.497035573 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Pyrimidine metabolism 0 -0.454545455 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Pyruvate metabolism 0 -0.42687747 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Ras signaling pathway 0 -0.491106719 0 yes kegg kegg NA NA no up up no up up Synaptic vesicle cycle Renin-angiotensin system 0.534782609 0.78458498 0.541570142 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Ribosome 0 -0.477272727 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Ribosome biogenesis in eukaryotes -0.550434783 -0.687747036 -0.447619048 kegg kegg NA NA no up up no no no Synaptic vesicle cycle RNA degradation 0 -0.843873518 -0.445559846 kegg kegg NA NA no up up no no no Synaptic vesicle cycle RNA polymerase -0.506086957 -0.785573123 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle RNA transport -0.445217391 -0.444664032 -0.538738739 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Signaling pathways regulating pluripotency of stem cells 0 -0.552371542 -0.437837838 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Sphingolipid metabolism 0.547826087 0 0.514800515 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Spliceosome -0.482608696 -0.553359684 -0.581981982 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Starch and sucrose metabolism 0.505217391 0.712450593 0.833462033 kegg kegg NA NA no up up no no no Synaptic vesicle cycle T cell receptor signaling pathway 0 0 -0.487001287 kegg kegg NA NA no up up no no no Synaptic vesicle cycle TGF-beta signaling pathway 0 -0.473320158 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Thermogenesis 0 -0.56027668 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Tight junction 0 0 0.405662806 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Toll-like receptor signaling pathway 0 0.549407115 0 yes kegg kegg NA NA no up up no no no Synaptic vesicle cycle Ubiquitin mediated proteolysis 0 -0.590909091 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Various types of N-glycan biosynthesis -0.457391304 -0.659090909 -0.423423423 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Viral protein interaction with cytokine and cytokine receptor 0 0.636363636 0 kegg kegg NA NA no up up no no no Synaptic vesicle cycle Wnt signaling pathway 0 -0.804347826 0 kegg kegg NA NA no up up no no no Synergistes Methanobrevibacter 0 0.512286901 0 Genus Genus 0.0843 0.629 no no no no no no Synergistes Methanosphaera 0 0.469999263 0 Genus Genus 0.0843 0.0703 no no no no no no Synthesis and degradation of ketone bodies Ascorbate and aldarate metabolism 0.51826087 0 0.593307593 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Citrate cycle (TCA cycle) 0.8 0.785573123 0.711969112 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Fatty acid degradation 0 0 0.433204633 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Fatty acid elongation 0.542608696 0.424901186 0.556241956 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Glycolysis / Gluconeogenesis 0.503478261 0.444664032 0 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Pentose and glucuronate interconversions 0.672173913 0.719367589 0.463835264 kegg kegg NA NA no no no no no no Synthesis and degradation of ketone bodies Pentose phosphate pathway 0 -0.503952569 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Adrenergic signaling in cardiomyocytes -0.56173913 -0.566205534 -0.432689833 kegg kegg NA NA no no no no no up Systemic lupus erythematosus AGE-RAGE signaling pathway in diabetic complications 0 0.489130435 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Akkermansia 0.426994086 0 0 acetate-producing kegg Genus NA 0.23 no no no no no no Systemic lupus erythematosus "Alanine, aspartate and glutamate metabolism" 0.439130435 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Alcoholism 0 0.463438735 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Aldosterone synthesis and secretion -0.546956522 -0.701581028 0 kegg kegg NA NA no no no no up up Systemic lupus erythematosus Alzheimer disease -0.494782609 -0.455533597 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Aminoacyl-tRNA biosynthesis 0 -0.508893281 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Amoebiasis 0 0.4743083 0.497039897 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Amphetamine addiction -0.650434783 -0.726284585 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus AMPK signaling pathway 0 -0.75 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Amyotrophic lateral sclerosis -0.513043478 -0.533596838 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Antifolate resistance 0 -0.548418972 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Antigen processing and presentation 0.446956522 0.524703557 0.615186615 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Apelin signaling pathway -0.443478261 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Apoptosis 0 0.610671937 0.50965251 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Arginine and proline metabolism 0 0.555335968 0 kegg kegg NA NA no no no no up no Systemic lupus erythematosus Arginine biosynthesis 0.48173913 0.423913043 0.466409266 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Asthma 0 0 0.597425997 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Autoimmune thyroid disease 0.405217391 0.687747036 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Autophagy - other 0 0 -0.506306306 kegg kegg NA NA no no no no no no Systemic lupus erythematosus B cell receptor signaling pathway 0 0.472332016 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Bacteroides 0.422608696 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Systemic lupus erythematosus Basal cell carcinoma -0.506086957 -0.659090909 -0.725096525 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Basal transcription factors 0 -0.663043478 -0.555727156 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Base excision repair 0 -0.611660079 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus beta-Alanine metabolism 0.44173913 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Bile secretion -0.543478261 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Biosynthesis of amino acids 0.519130435 0.747035573 0.698326898 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Biosynthesis of cofactors 0 -0.625494071 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Bladder cancer 0.46173913 0.500988142 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus C-type lectin receptor signaling pathway 0 0.470355731 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Calcium signaling pathway 0 -0.447628458 -0.417245817 kegg kegg NA NA no no no no up up Systemic lupus erythematosus cAMP signaling pathway -0.543478261 0 0 yes kegg kegg NA NA no no no no up up Systemic lupus erythematosus Carbon metabolism 0.411304348 0.597826087 0.652252252 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Cardiac muscle contraction -0.44 -0.459486166 0 kegg kegg NA NA no no no no no up Systemic lupus erythematosus Cell adhesion molecules 0.408695652 0.722332016 0.410810811 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Cell cycle 0 -0.769762846 -0.541312741 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Cellular senescence 0 0.608695652 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus cGMP-PKG signaling pathway 0 0.81916996 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Chemical carcinogenesis - DNA adducts 0 0.500988142 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Chemical carcinogenesis - receptor activation -0.694782609 -0.691699605 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Chemokine signaling pathway 0 0.589920949 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Cholesterol metabolism 0 0.618577075 0 yes kegg kegg NA NA no no no no no up Systemic lupus erythematosus Choline metabolism in cancer 0 0 -0.457657658 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Circadian entrainment -0.466086957 0 0 kegg kegg NA NA no no no no up up Systemic lupus erythematosus Circadian rhythm 0 -0.790513834 -0.666151866 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Clostridium 0 0.438086354 0 kegg Genus NA 0.925 no no no no no no Systemic lupus erythematosus Cocaine addiction -0.55826087 -0.626482213 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Colorectal cancer -0.406956522 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Complement and coagulation cascades 0.428695652 0.824110672 0.693178893 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Coronavirus disease - COVID-19 -0.637391304 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Cortisol synthesis and secretion -0.630434783 -0.70256917 0 kegg kegg NA NA no no no no no up Systemic lupus erythematosus Cushing syndrome -0.669565217 -0.815217391 -0.456628057 kegg kegg NA NA no no no no no up Systemic lupus erythematosus Cytokine-cytokine receptor interaction 0 0.449604743 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus DNA replication 0 -0.529644269 -0.466151866 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Dopaminergic synapse -0.613913043 0 0 kegg kegg NA NA no no no no up no Systemic lupus erythematosus EGFR tyrosine kinase inhibitor resistance -0.420869565 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Endocrine and other factor-regulated calcium reabsorption -0.455652174 -0.600790514 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Endocrine resistance -0.566086957 -0.602766798 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Endocytosis 0 0.738142292 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Epithelial cell signaling in Helicobacter pylori infection 0 0.65513834 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Epstein-Barr virus infection 0 0.5256917 0.415958816 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Estrogen signaling pathway 0 -0.455533597 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Ether lipid metabolism -0.419130435 -0.577075099 -0.433976834 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Fanconi anemia pathway 0 -0.665019763 -0.458687259 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Fat digestion and absorption 0 0.663043478 0 yes kegg kegg NA NA no no no no up up Systemic lupus erythematosus Fatty acid biosynthesis 0.41826087 0.459486166 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Fatty acid degradation 0.48 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Fatty acid elongation 0.588695652 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Fatty acid metabolism 0.665217391 0.505928854 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Fc epsilon RI signaling pathway 0 0.601778656 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Fc gamma R-mediated phagocytosis 0.623478261 0.871541502 0.723294723 kegg kegg NA NA no no no no no no Systemic lupus erythematosus GABAergic synapse 0.447826087 0.423913043 0.406177606 kegg kegg NA NA no no no no up up Systemic lupus erythematosus Galactose metabolism 0.46 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Gastric cancer 0 -0.472332016 -0.512741313 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Glucagon signaling pathway -0.631304348 -0.768774704 -0.518918919 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Glutathione metabolism 0 -0.504940711 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Glycerolipid metabolism 0 0 -0.542599743 kegg kegg NA NA no no no no no up Systemic lupus erythematosus Glycerophospholipid metabolism 0 0 -0.576319176 kegg kegg NA NA no no no no no up Systemic lupus erythematosus "Glycine, serine and threonine metabolism" 0 -0.599802372 0 kegg kegg NA NA no no no no up no Systemic lupus erythematosus Glycolysis / Gluconeogenesis 0 0 0.452509653 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Glycosaminoglycan biosynthesis - keratan sulfate 0 0 -0.495238095 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Glycosaminoglycan degradation 0 0.668972332 0 kegg kegg NA NA no no no no no up Systemic lupus erythematosus Glycosphingolipid biosynthesis - ganglio series 0 -0.451581028 -0.465637066 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 -0.497812098 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.634387352 -0.528185328 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Glyoxylate and dicarboxylate metabolism 0.636521739 0.475296443 0.470527671 kegg kegg NA NA no no no no no no Systemic lupus erythematosus GnRH signaling pathway -0.422608696 -0.588932806 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus "Growth hormone synthesis, secretion and action" -0.429565217 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Hedgehog signaling pathway 0 -0.691699605 -0.571685972 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Hematopoietic cell lineage 0 0 0.417245817 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Herpes simplex virus 1 infection 0 0.491106719 0.440669241 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Hippo signaling pathway - multiple species 0.436521739 0.428853755 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Homologous recombination 0 -0.542490119 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Human cytomegalovirus infection 0 0.544466403 0.405920206 kegg kegg NA NA no no no no no dn Systemic lupus erythematosus Human immunodeficiency virus 1 infection 0 0.517786561 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Human papillomavirus infection 0 0.531620553 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Human T-cell leukemia virus 1 infection 0 0.480237154 0.518661519 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Huntington disease -0.444347826 -0.48715415 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus IL-17 signaling pathway 0 0.799407115 0.48005148 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Inflammatory bowel disease 0.462608696 0.568181818 0.558815959 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Inflammatory mediator regulation of TRP channels -0.535652174 -0.527667984 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Influenza A 0.446086957 0.671936759 0.485199485 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Inositol phosphate metabolism 0 0 -0.498326898 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Insulin resistance 0 0 -0.416216216 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Insulin secretion -0.533913043 -0.688735178 0 yes kegg kegg NA NA no no no no up up Systemic lupus erythematosus Insulin signaling pathway -0.425217391 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Intestinal immune network for IgA production 0 0 0.511454311 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Kaposi sarcoma-associated herpesvirus infection -0.462608696 0 0 kegg kegg NA NA no no no no no dn Systemic lupus erythematosus Leishmaniasis 0.413913043 0 0.578378378 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Leukocyte transendothelial migration 0 0.513833992 0.506563707 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Long-term depression -0.428695652 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Longevity regulating pathway 0 -0.415019763 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Lysine degradation 0 -0.666007905 -0.614929215 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Lysosome 0.511304348 0.913043478 0.522007722 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Mannose type O-glycan biosynthesis 0 -0.563241107 -0.657915058 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Melanogenesis -0.562608696 -0.537549407 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Mineral absorption -0.512173913 -0.428853755 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Mitophagy - animal -0.644347826 -0.585968379 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Morphine addiction -0.473043478 -0.466403162 0 kegg kegg NA NA no no no no up up Systemic lupus erythematosus mRNA surveillance pathway -0.424347826 -0.717391304 -0.714543115 kegg kegg NA NA no no no no no no Systemic lupus erythematosus mTOR signaling pathway -0.447826087 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus N-Glycan biosynthesis 0 -0.581027668 -0.477734878 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Natural killer cell mediated cytotoxicity 0 0.668972332 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Necroptosis -0.507826087 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Neuroactive ligand-receptor interaction 0 0.911067194 0.600514801 kegg kegg NA NA no no no up up up Systemic lupus erythematosus Neutrophil extracellular trap formation 0.59826087 0.893280632 0.757014157 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Nicotinate and nicotinamide metabolism 0.486086957 0.572134387 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Nicotine addiction 0 -0.513833992 0 kegg kegg NA NA no no no no up up Systemic lupus erythematosus Nitrogen metabolism 0 0.422924901 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus NOD-like receptor signaling pathway 0.463478261 0.489130435 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Non-alcoholic fatty liver disease -0.533913043 -0.446640316 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Non-small cell lung cancer 0 0 -0.494723295 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Notch signaling pathway 0 0 -0.547232947 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Nucleotide excision repair 0 -0.563241107 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Olfactory transduction 0 0.765810277 0.470527671 kegg kegg NA NA no no no no no no Systemic lupus erythematosus One carbon pool by folate 0 -0.570158103 -0.491891892 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Osteoclast differentiation 0.48173913 0.716403162 0.497554698 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Other types of O-glycan biosynthesis 0 -0.690711462 -0.59047619 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Ovarian steroidogenesis -0.509565217 0 0 kegg kegg NA NA no no no no up up Systemic lupus erythematosus Oxidative phosphorylation -0.450434783 -0.429841897 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Oxytocin signaling pathway 0 0 0.486743887 kegg kegg NA NA no no no no no no Systemic lupus erythematosus p53 signaling pathway 0 -0.510869565 -0.488030888 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Pancreatic secretion -0.48 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Pantothenate and CoA biosynthesis 0.422608696 0.648221344 0 kegg kegg NA NA no no no no no dn Systemic lupus erythematosus "Parathyroid hormone synthesis, secretion and action" -0.690434783 -0.494071146 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Parkinson disease -0.600869565 -0.485177866 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Pathogenic Escherichia coli infection 0 0.760869565 0.565765766 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Pathways in cancer 0 0 -0.402574003 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Pathways of neurodegeneration - multiple diseases -0.597391304 -0.527667984 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Pentose and glucuronate interconversions 0 -0.416007905 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Pentose phosphate pathway 0.432173913 0.886363636 0.619047619 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Peroxisome 0.592173913 0.542490119 0.436550837 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Pertussis 0.54173913 0.841897233 0.74028314 kegg kegg NA NA no no no no no dn Systemic lupus erythematosus Phagosome 0.506086957 0.841897233 0.592535393 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Phosphatidylinositol signaling system 0 -0.446640316 -0.642471042 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Platinum drug resistance 0 -0.441699605 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Porphyrin and chlorophyll metabolism 0 -0.603754941 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus PPAR signaling pathway 0 0.533596838 0.417245817 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Primary bile acid biosynthesis 0 0 0.462805663 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Prion disease -0.485217391 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Progesterone-mediated oocyte maturation 0 -0.499011858 -0.45997426 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Protein digestion and absorption 0.523478261 0.54743083 0 yes kegg kegg NA NA no no no no up up Systemic lupus erythematosus Protein export 0 0 -0.439124839 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Protein processing in endoplasmic reticulum -0.405217391 -0.696640316 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Proteoglycans in cancer -0.41826087 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Purine metabolism 0 -0.757905138 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Pyrimidine metabolism 0.426956522 -0.416007905 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Ras signaling pathway 0 0 -0.444015444 yes kegg kegg NA NA no no no no up up Systemic lupus erythematosus Regulation of lipolysis in adipocytes -0.593043478 -0.415019763 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Relaxin signaling pathway -0.520869565 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Renin secretion -0.484347826 -0.418972332 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Renin-angiotensin system 0.555652174 0.90513834 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Ribosome -0.624347826 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Ribosome biogenesis in eukaryotes 0 -0.747035573 -0.584555985 kegg kegg NA NA no no no no no no Systemic lupus erythematosus RNA degradation 0 -0.60770751 -0.557786358 kegg kegg NA NA no no no no no no Systemic lupus erythematosus RNA polymerase 0 -0.788537549 -0.481081081 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Ruminococcus -0.427826087 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Systemic lupus erythematosus Salmonella infection 0 0.694664032 0.595366795 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Selenocompound metabolism 0 -0.562252964 -0.464607465 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Shigellosis -0.531304348 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Signaling pathways regulating pluripotency of stem cells -0.445217391 -0.490118577 -0.549034749 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Sphingolipid signaling pathway 0 0.590909091 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Spinocerebellar ataxia 0 -0.658102767 -0.489317889 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Spliceosome 0 -0.562252964 -0.461776062 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Staphylococcus aureus infection 0.872173913 0.958498024 0.925096525 kegg kegg NA NA no no no up no no Systemic lupus erythematosus Starch and sucrose metabolism 0 0.516798419 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Synaptic vesicle cycle 0 0.763833992 0 kegg kegg NA NA no no no no up up Systemic lupus erythematosus Synthesis and degradation of ketone bodies 0 -0.458498024 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Taste transduction 0 -0.59486166 -0.583526384 kegg kegg NA NA no no no no no up Systemic lupus erythematosus Taurine and hypotaurine metabolism 0 0 -0.566537967 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Terpenoid backbone biosynthesis 0 0 -0.465894466 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Thermogenesis -0.524347826 -0.459486166 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Thyroid hormone synthesis -0.446086957 -0.593873518 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Tight junction 0 0 0.512998713 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Toll-like receptor signaling pathway 0 0.523715415 0 yes kegg kegg NA NA no no no no no no Systemic lupus erythematosus Toxoplasmosis 0.429565217 0.57312253 0.559330759 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Tuberculosis 0.876521739 0.947628458 0.835263835 kegg kegg NA NA no no no no no dn Systemic lupus erythematosus Type I diabetes mellitus 0.405217391 0.68083004 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Ubiquinone and other terpenoid-quinone biosynthesis 0 0 -0.429086229 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Ubiquitin mediated proteolysis -0.643478261 -0.688735178 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Various types of N-glycan biosynthesis 0 -0.443675889 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Vascular smooth muscle contraction -0.515652174 0 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Vasopressin-regulated water reabsorption -0.573913043 -0.485177866 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Viral carcinogenesis 0 0.611660079 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Viral protein interaction with cytokine and cytokine receptor 0 0.520750988 0 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Wnt signaling pathway 0 -0.62944664 -0.584555985 kegg kegg NA NA no no no no no no Systemic lupus erythematosus Yersinia infection 0 0.801383399 0 kegg kegg NA NA no no no no no no Systolic_Pressure+clinic 16:0/22:6-PC+blood 0 0.610714286 0 clinic serum_phospholipids 0.00205 4.53E-05 up up no no up up Systolic_Pressure+clinic 16:1/18:2-PG+blood 0 -0.667857143 0 clinic serum_phospholipids 0.00205 1.40E-08 up up no no up up Systolic_Pressure+clinic 18:0-LPA+blood 0 0 -0.405384615 clinic serum_phospholipids 0.00205 0.0725 up up no no dn no Systolic_Pressure+clinic 18:0-LPC+blood -0.574819401 0 0 clinic serum_phospholipids 0.00205 0.554 up up no no no no Systolic_Pressure+clinic 18:0-LPE+blood -0.55624355 0 0.508461538 clinic serum_phospholipids 0.00205 0.491 up up no no no no Systolic_Pressure+clinic 18:0/20:3-PC+blood -0.574819401 0 0 clinic serum_phospholipids 0.00205 0.0682 up up no no up no Systolic_Pressure+clinic 18:0/20:4-PC+blood 0 0.7 0 clinic serum_phospholipids 0.00205 0.454 up up no no no no Systolic_Pressure+clinic 18:0/20:5-PC+blood 0 0.646428571 0 clinic serum_phospholipids 0.00205 0.17 up up no no no no Systolic_Pressure+clinic 18:0+blood -0.50877193 0 0 clinic serum_fattyacid 0.00205 0.344 up up no no no no Systolic_Pressure+clinic 18:1/18:1-PE+blood 0 -0.525 0 clinic serum_phospholipids 0.00205 1.03E-05 up up no up up no Systolic_Pressure+clinic 18:1/20:4-PC+blood 0 0.589285714 0 clinic serum_phospholipids 0.00205 0.582 up up no no no no Systolic_Pressure+clinic 20:2/18:0-PC+blood -0.51496388 0 0 clinic serum_phospholipids 0.00205 0.0427 up up no no up no Systolic_Pressure+clinic 20:3n6+blood -0.630546956 -0.564285714 0 clinic serum_fattyacid 0.00205 0.0884 up up no up no no Systolic_Pressure+clinic 20:5/18:0-PC+blood 0 0.564285714 0 clinic serum_phospholipids 0.00205 3.97E-06 up up no no up up Systolic_Pressure+clinic 22:6n3+blood -0.543859649 0 -0.425384615 clinic serum_fattyacid 0.00205 0.792 up up no no no no Systolic_Pressure+clinic 4-hydroxybenzoic acid+urine 0 0.600490196 0 clinic urine_cometabolism 0.00205 0.52 up up no no no no Systolic_Pressure+clinic 9-HODE+blood 0 0 0.696153846 clinic serum_ARA 0.00205 0.297 up up no no no no Systolic_Pressure+clinic Acetic acid+stool 0 0.645454545 0 yes clinic stool_scfa 0.00205 0.0656 up up no dn no no Systolic_Pressure+clinic Apoptosis 0.523433089 0 0 clinic kegg 0.00205 NA up up no no no no Systolic_Pressure+clinic Biosynthesis of amino acids 0 0 -0.400560224 clinic kegg 0.00205 NA up up no no no no Systolic_Pressure+clinic C-peptide 0 -0.613777527 -0.402291826 clinic DM-assocaited hormones 0.00205 0.228 up up no no no no Systolic_Pressure+clinic CA+blood 0.475993868 0 0 clinic serum_bileacids 0.00205 0.606 up up no no no no Systolic_Pressure+clinic Carbon metabolism 0 0 -0.462464986 clinic kegg 0.00205 NA up up no no no no Systolic_Pressure+clinic Creatinine+blood 0 -0.564285714 -0.443076923 clinic serum_choline 0.00205 0.437 up up no no no no Systolic_Pressure+clinic Cytosolic DNA-sensing pathway 0.647656691 0 0 clinic kegg 0.00205 NA up up no no no no Systolic_Pressure+clinic d18:1-16:1-SM+blood 0 0 0.423076923 clinic serum_phospholipids 0.00205 0.2 up up no no no no Systolic_Pressure+clinic d18:1-18:1-SM+blood 0 0 0.408461538 clinic serum_phospholipids 0.00205 0.916 up up no no no no Systolic_Pressure+clinic Eotaxin 0 0 0.515270936 clinic serum_cytokines 0.00205 0.393 up up no no no no Systolic_Pressure+clinic Glycolysis / Gluconeogenesis 0 0 -0.403641457 clinic kegg 0.00205 NA up up no no no no Systolic_Pressure+clinic Homovanillic acid+urine -0.475748194 0 0 clinic urine_cometabolism 0.00205 0.45 up up no no no no Systolic_Pressure+clinic L-Isoleucine+blood 0 -0.564285714 -0.548461538 yes clinic serum_aminoacids 0.00205 5.47E-06 up up no up up no Systolic_Pressure+clinic L-Leucine+blood 0 -0.539285714 -0.420769231 yes clinic serum_aminoacids 0.00205 3.22E-05 up up no up up no Systolic_Pressure+clinic L-Phenylalanine+blood 0 -0.553571429 0 yes clinic serum_aminoacids 0.00205 0.0103 up up no up up no Systolic_Pressure+clinic L-Proline+blood 0 -0.739285714 0 yes clinic serum_aminoacids 0.00205 0.00265 up up no up up no Systolic_Pressure+clinic L-Tryptophan+blood 0 -0.696428571 0 clinic serum_aminoacids 0.00205 0.164 up up no no no no Systolic_Pressure+clinic L-Tyrosine+blood 0 -0.707142857 0 yes clinic serum_aminoacids 0.00205 0.00913 up up no up up no Systolic_Pressure+clinic Leukocyte transendothelial migration 0.429700734 0 0 clinic kegg 0.00205 NA up up no no no no Systolic_Pressure+clinic MIP-1b 0 0 0.555665025 clinic serum_cytokines 0.00205 0.632 up up no no no no Systolic_Pressure+clinic n3+blood 0 0 -0.436923077 clinic serum_fattyacid 0.00205 0.806 up up no no no no Systolic_Pressure+clinic Non-small cell lung cancer 0 0 0.415406162 clinic kegg 0.00205 NA up up no no no no Systolic_Pressure+clinic P-hydroxyhippuric acid+urine -0.496388029 0 0 clinic urine_cometabolism 0.00205 0.436 up up no no no no Systolic_Pressure+clinic Parabacteroides 0 0.483907397 0 clinic Genus 0.00205 4.19E-05 up up no no up up Systolic_Pressure+clinic PUFA/MUFA+blood 0.566563467 0 0 clinic serum_fattyacid 0.00205 0.00108 up up no dn no up Systolic_Pressure+clinic RANTES 0 0 0.522660099 yes clinic serum_cytokines 0.00205 0.0757 up up no no no up Systolic_Pressure+clinic SFA%+blood 0 0 -0.446923077 clinic serum_fattyacid 0.00205 0.0236 up up no no up no Systolic_Pressure+clinic Systemic lupus erythematosus 0 0 -0.434173669 clinic kegg 0.00205 NA up up no no no no Systolic_Pressure+clinic TCA+blood -0.48374236 0 0 clinic serum_bileacids 0.00205 0.339 up up no no no no Systolic_Pressure+clinic TMAO+blood 0 0 -0.405384615 clinic serum_choline 0.00205 0.00706 up up no up up no Systolic_Pressure+clinic TXB2+blood 0 0.746932502 0 yes clinic serum_ARA 0.00205 0.0644 up up no dn no no Systolic_Pressure+clinic Valine+blood 0 -0.567857143 -0.544615385 yes clinic serum_aminoacids 0.00205 1.22E-06 up up no up up no Systolic_Pressure+clinic Visfatin 0 0 0.500993125 clinic DM-assocaited hormones 0.00205 0.0229 up up no dn no up T cell receptor signaling pathway ABC transporters 0 0.549407115 0 kegg kegg NA NA no no no no up up T cell receptor signaling pathway Adherens junction 0 -0.748023715 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway "Alanine, aspartate and glutamate metabolism" 0 0.448616601 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Alistipes 0 0.503716255 0 kegg Genus NA 0.0114 no no no no up no T cell receptor signaling pathway Amino sugar and nucleotide sugar metabolism 0 0 -0.44041184 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Apoptosis - multiple species 0 0.501976285 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Arachidonic acid metabolism -0.592173913 -0.462450593 -0.742084942 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Autophagy - animal 0.513913043 0.684782609 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Autophagy - other 0.613043478 0.753952569 0.727927928 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Axon guidance 0 0 0.644530245 kegg kegg NA NA no no no no up up T cell receptor signaling pathway Basal transcription factors 0 0 0.463320463 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Biosynthesis of cofactors 0 0 -0.414671815 kegg kegg NA NA no no no no no no T cell receptor signaling pathway C-type lectin receptor signaling pathway 0.50173913 0.617588933 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Cardiac muscle contraction 0 -0.457509881 0 kegg kegg NA NA no no no no no up T cell receptor signaling pathway Cell cycle 0 0 0.468211068 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Collinsella 0 0 -0.525641669 kegg Genus NA 0.128 no no no no no no T cell receptor signaling pathway Cytosolic DNA-sensing pathway 0 0.593873518 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Drug metabolism - cytochrome P450 0 -0.463438735 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Drug metabolism - other enzymes 0 -0.523715415 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway ErbB signaling pathway 0 0.563241107 0.558301158 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Fatty acid degradation 0 0.433794466 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Ferroptosis -0.445217391 0 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Focal adhesion 0 -0.696640316 0 kegg kegg NA NA no no no no up up T cell receptor signaling pathway Folate biosynthesis 0.413913043 0 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway FoxO signaling pathway 0.431304348 0.591897233 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Glutathione metabolism -0.535652174 -0.508893281 -0.590733591 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Glycerolipid metabolism 0 0.507905138 0 kegg kegg NA NA no no no no no up T cell receptor signaling pathway Glycerophospholipid metabolism 0 0.441699605 0 kegg kegg NA NA no no no no no up T cell receptor signaling pathway "Glycine, serine and threonine metabolism" 0 0 -0.406949807 kegg kegg NA NA no no no no up no T cell receptor signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.511857708 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.468725869 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Glycosphingolipid biosynthesis - ganglio series -0.479130435 0 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.415019763 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Hematopoietic cell lineage -0.522608696 0 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Hippo signaling pathway 0 -0.644268775 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Inositol phosphate metabolism 0 0.520750988 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway JAK-STAT signaling pathway 0 0.630434783 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Lachnospira 0 -0.570793198 0 butyrate-producing kegg Genus NA 0.279 no no no no no no T cell receptor signaling pathway Lysine degradation 0.435652174 0.427865613 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Mannose type O-glycan biosynthesis 0 0.424901186 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway MAPK signaling pathway 0.473043478 0.580039526 0.482625483 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.504940711 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway mRNA surveillance pathway 0 0 0.444015444 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Mucin type O-glycan biosynthesis 0 0.639328063 0.471814672 kegg kegg NA NA no no no no no no T cell receptor signaling pathway N-Glycan biosynthesis 0 0 0.524581725 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Neutrophil extracellular trap formation 0 0 -0.423166023 kegg kegg NA NA no no no no no no T cell receptor signaling pathway NF-kappa B signaling pathway 0.447826087 0.666007905 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway NOD-like receptor signaling pathway 0 0.619565217 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Oocyte meiosis 0 0 0.497812098 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Oscillospira 0 0.442687747 0 LPS-producing kegg Genus NA 0.62 no no no no no no T cell receptor signaling pathway Osteoclast differentiation 0 0.428853755 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Other glycan degradation 0 0.52173913 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Oxidative phosphorylation 0 -0.52173913 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway p53 signaling pathway 0 0.454545455 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Pentose phosphate pathway 0 0 -0.444530245 kegg kegg NA NA no no no no no no T cell receptor signaling pathway PI3K-Akt signaling pathway 0.716521739 0.416996047 0.432689833 yes kegg kegg NA NA no no no no up up T cell receptor signaling pathway Platelet activation 0 -0.833992095 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Platinum drug resistance 0 0.503952569 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Porphyrin and chlorophyll metabolism 0 0 -0.401029601 kegg kegg NA NA no no no no no no T cell receptor signaling pathway PPAR signaling pathway 0 0.559288538 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Purine metabolism -0.433913043 0 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Pyrimidine metabolism 0 -0.441699605 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Rap1 signaling pathway 0 -0.740118577 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Ras signaling pathway 0 -0.416996047 0 yes kegg kegg NA NA no no no no up up T cell receptor signaling pathway Ribosome biogenesis in eukaryotes 0 0 0.450965251 kegg kegg NA NA no no no no no no T cell receptor signaling pathway RIG-I-like receptor signaling pathway 0.630434783 0.709486166 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway RNA degradation 0 0 0.498069498 kegg kegg NA NA no no no no no no T cell receptor signaling pathway RNA transport 0.546956522 0 0.463835264 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Roseburia -0.471304348 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no T cell receptor signaling pathway Signaling pathways regulating pluripotency of stem cells 0.474782609 0.444664032 0.611325611 kegg kegg NA NA no no no no no no T cell receptor signaling pathway SNARE interactions in vesicular transport 0 0.627470356 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Spliceosome 0.565217391 0.602766798 0.602316602 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Starch and sucrose metabolism 0 0 -0.473616474 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Steroid biosynthesis 0 -0.422924901 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Steroid hormone biosynthesis 0 -0.490118577 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Sulfur metabolism -0.485217391 0 -0.543114543 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Taurine and hypotaurine metabolism 0 0.461462451 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Terpenoid backbone biosynthesis 0 0 0.435263835 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Th1 and Th2 cell differentiation 0 0.504940711 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Th17 cell differentiation 0 0.614624506 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Tight junction 0 -0.693675889 -0.641441441 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Toll-like receptor signaling pathway 0.446086957 0.524703557 0 yes kegg kegg NA NA no no no no no no T cell receptor signaling pathway Tyrosine metabolism 0 -0.503952569 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Various types of N-glycan biosynthesis 0.471304348 0 0.623680824 kegg kegg NA NA no no no no no no T cell receptor signaling pathway Vascular smooth muscle contraction 0 -0.697628458 0 kegg kegg NA NA no no no no no no T cell receptor signaling pathway VEGF signaling pathway 0 0 0.457657658 kegg kegg NA NA no no no no no no T-a-MCA+blood 16:0/16:0-PC+blood 0 0 0.505728963 serum_bileacids serum_phospholipids 0.478 0.00079 no no no no up up T-a-MCA+blood 16:0/18:0-PC+blood 0 0 0.494641117 serum_bileacids serum_phospholipids 0.478 0.521 no no no no no no T-a-MCA+blood 16:0/18:1-PC+blood 0 0 0.405938352 serum_bileacids serum_phospholipids 0.478 6.15E-07 no no no up up up T-a-MCA+blood 16:0/22:6-PC+blood 0 0 0.524208706 serum_bileacids serum_phospholipids 0.478 4.53E-05 no no no no up up T-a-MCA+blood 16:1/16:0-PC+blood 0 0 0.453985683 serum_bileacids serum_phospholipids 0.478 0.0215 no no no no up up T-a-MCA+blood 18:0/18:0-PC+blood 0 0 0.40101042 serum_bileacids serum_phospholipids 0.478 0.426 no no no no no no T-a-MCA+blood 18:0/18:1-PC+blood 0 0 0.433041975 serum_bileacids serum_phospholipids 0.478 0.393 no no no no no no T-a-MCA+blood 18:0/18:2-PC+blood 0 0 0.52174474 serum_bileacids serum_phospholipids 0.478 1.74E-06 no no no no up up T-a-MCA+blood 18:0+blood 0 0 0.430578009 serum_bileacids serum_fattyacid 0.478 0.344 no no no no no no T-a-MCA+blood 18:1/18:0-PC+blood 0 0 0.489713186 serum_bileacids serum_phospholipids 0.478 1.83E-06 no no no no up up T-a-MCA+blood 18:1+blood 0 0 0.465073529 yes serum_bileacids serum_fattyacid 0.478 0.00202 no no no up no dn T-a-MCA+blood 18:2/16:0-PC+blood 0 0 0.48724922 serum_bileacids serum_phospholipids 0.478 8.67E-05 no no no no up up T-a-MCA+blood 18:2n6c+blood 0 0 0.492177152 serum_bileacids serum_fattyacid 0.478 0.15 no no no no no no T-a-MCA+blood 18:3n3+blood 0 0 0.4958731 serum_bileacids serum_fattyacid 0.478 0.291 no no no no no no T-a-MCA+blood 20:3/18:0-PC+blood 0 0 0.436737923 serum_bileacids serum_phospholipids 0.478 0.296 no no no no no no T-a-MCA+blood 20:5/18:0-PC+blood 0 0 0.492177152 serum_bileacids serum_phospholipids 0.478 3.97E-06 no no no no up up T-a-MCA+blood 22:1-LPA+blood 0 0 -0.407170335 serum_bileacids serum_phospholipids 0.478 0.00373 no no no no up up T-a-MCA+blood 24:1+blood 0 0 0.425650077 serum_bileacids serum_fattyacid 0.478 0.00582 no no no no dn dn T-a-MCA+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.463260862 serum_bileacids stool_cometabolism 0.478 0.33 no no no no no no T-a-MCA+blood CDCA+blood 0 0 -0.429346026 serum_bileacids serum_bileacids 0.478 0.506 no no no no no no T-a-MCA+blood Coronavirus disease - COVID-19 0 0 0.488377015 serum_bileacids kegg 0.478 NA no no no no no no T-a-MCA+blood GCDCA+blood 0 0 -0.439201889 serum_bileacids serum_bileacids 0.478 0.31 no no no no no no T-a-MCA+blood HIF-1 signaling pathway 0 0 0.440016111 serum_bileacids kegg 0.478 NA no no no no no no T-a-MCA+blood L-2-Aminobutyric acid+blood 0 0 0.405938352 yes serum_bileacids serum_aminoacids 0.478 0.000328 no no no up up no T-a-MCA+blood L-Arginine+blood 0 0 0.449057752 serum_bileacids serum_aminoacids 0.478 0.316 no no no no no no T-a-MCA+blood L-Glutamine+blood 0 0 0.458913615 serum_bileacids serum_aminoacids 0.478 0.639 no no no no no no T-a-MCA+blood Lachnobacterium 0 0 0.50449698 serum_bileacids Genus 0.478 0.867 no no no no no no T-a-MCA+blood Leishmaniasis 0 0 0.4018723 serum_bileacids kegg 0.478 NA no no no no no no T-a-MCA+blood Methanobrevibacter 0 0 0.559977798 serum_bileacids Genus 0.478 0.629 no no no no no no T-a-MCA+blood mTOR signaling pathway 0 0 0.422987624 serum_bileacids kegg 0.478 NA no no no no no no T-a-MCA+blood MUFA+blood 0 0 0.466305512 serum_bileacids serum_fattyacid 0.478 0.00175 no no no up no dn T-a-MCA+blood n6+blood 0 0 0.434273957 serum_bileacids serum_fattyacid 0.478 0.153 no no no no no no T-a-MCA+blood Odoribacter 0 0 -0.415696089 butyrate-producing serum_bileacids Genus 0.478 0.798 no no no no no no T-a-MCA+blood PUFA+blood 0 0 0.484785255 serum_bileacids serum_fattyacid 0.478 0.212 no no no no no no T-a-MCA+blood Ribosome 0 0 0.488377015 serum_bileacids kegg 0.478 NA no no no no no no T-¦Á-MCA+stool 5-Hydroxytryptamine+stool 0 0.578273758 0 stool_bileacids stool_cometabolism 0.48 0.00862 no no no dn dn no T-¦Á-MCA+stool Butyric acid+stool 0.603544438 0 0 yes stool_bileacids stool_scfa 0.48 0.102 no no no dn no no T-¦Á-MCA+stool CA+stool -0.561751136 -0.697600089 0 stool_bileacids stool_bileacids 0.48 0.827 no no no no no no T-¦Á-MCA+stool GCA+stool 0 0 -0.423603135 stool_bileacids stool_bileacids 0.48 0.0809 no no no no no no T-¦Á-MCA+stool GDCA+stool 0 0 -0.452792834 stool_bileacids stool_bileacids 0.48 0.656 no no no no no no T-¦Á-MCA+stool HDCA+stool 0.528562338 0 0 stool_bileacids stool_bileacids 0.48 0.176 no no no no no no T-¦Á-MCA+stool iso-DCA+stool 0.603544438 0 0 stool_bileacids stool_bileacids 0.48 0.155 no no no no no no T-¦Á-MCA+stool iso-LCA+stool 0 0.642526398 0 stool_bileacids stool_bileacids 0.48 0.72 no no no no no no T-¦Á-MCA+stool Kynurenic acid+stool 0.556834278 0 0 stool_bileacids stool_cometabolism 0.48 0.037 no no no dn dn no T-¦Á-MCA+stool L-Tyrosine+stool 0 0.660884295 0 stool_bileacids stool_cometabolism 0.48 0.44 no no no no no no T-¦Á-MCA+stool LCA+stool 0.478164534 0 0 stool_bileacids stool_bileacids 0.48 0.314 no no no no no no T-¦Á-MCA+stool nutriCA+stool -0.500290399 -0.721017823 0 stool_bileacids stool_bileacids 0.48 0.481 no no no no no no Taste transduction 2-Oxocarboxylic acid metabolism 0 0.526679842 0.437323037 kegg kegg NA NA no no up no no no Taste transduction ABC transporters 0 0 0.588931789 kegg kegg NA NA no no up no up up Taste transduction "Alanine, aspartate and glutamate metabolism" 0 0 -0.431145431 kegg kegg NA NA no no up no no no Taste transduction Amino sugar and nucleotide sugar metabolism 0 0.511857708 0.413642214 kegg kegg NA NA no no up no no no Taste transduction Aminoacyl-tRNA biosynthesis 0 0.834980237 0.574517375 kegg kegg NA NA no no up no no no Taste transduction AMPK signaling pathway 0 0 -0.452509653 kegg kegg NA NA no no up no no no Taste transduction Antifolate resistance 0 0.665019763 0.513256113 kegg kegg NA NA no no up no no no Taste transduction Antigen processing and presentation 0 0 -0.571943372 kegg kegg NA NA no no up no no no Taste transduction Apoptosis 0 -0.72826087 0 kegg kegg NA NA no no up no no no Taste transduction Apoptosis - multiple species 0 0 0.440669241 kegg kegg NA NA no no up no no no Taste transduction Arachidonic acid metabolism 0 0 -0.454054054 kegg kegg NA NA no no up no no no Taste transduction Arginine and proline metabolism 0 -0.559288538 -0.403088803 kegg kegg NA NA no no up no up no Taste transduction Arginine biosynthesis 0 -0.431818182 -0.580952381 kegg kegg NA NA no no up no no no Taste transduction Ascorbate and aldarate metabolism 0 0 0.649420849 kegg kegg NA NA no no up no no no Taste transduction Autophagy - animal 0 -0.437747036 0 kegg kegg NA NA no no up no no no Taste transduction Autophagy - other 0 0 0.528185328 kegg kegg NA NA no no up no no no Taste transduction Axon guidance 0 -0.631422925 0 kegg kegg NA NA no no up no up up Taste transduction B cell receptor signaling pathway -0.424347826 -0.719367589 0 kegg kegg NA NA no no up no no no Taste transduction Basal transcription factors 0 0.747035573 0.676447876 kegg kegg NA NA no no up no no no Taste transduction Base excision repair 0 0.716403162 0.57014157 kegg kegg NA NA no no up no no no Taste transduction beta-Alanine metabolism 0 0.433794466 0 kegg kegg NA NA no no up no no no Taste transduction Biosynthesis of amino acids 0 -0.557312253 -0.642471042 kegg kegg NA NA no no up no no no Taste transduction Biosynthesis of cofactors 0 0.66798419 -0.424453024 kegg kegg NA NA no no up no no no Taste transduction Biosynthesis of unsaturated fatty acids 0.480869565 0.429841897 0 kegg kegg NA NA no no up no no no Taste transduction Butanoate metabolism 0 0.674901186 0 kegg kegg NA NA no no up no no no Taste transduction C-type lectin receptor signaling pathway 0 -0.700592885 0 kegg kegg NA NA no no up no no no Taste transduction cAMP signaling pathway 0 -0.666996047 0 yes kegg kegg NA NA no no up no up up Taste transduction Cell adhesion molecules -0.546086957 -0.564229249 -0.406692407 kegg kegg NA NA no no up no no no Taste transduction Cell cycle 0.768695652 0.803359684 0.713770914 kegg kegg NA NA no no up no no no Taste transduction Cellular senescence -0.54173913 -0.651185771 0 kegg kegg NA NA no no up no no no Taste transduction cGMP-PKG signaling pathway 0 -0.668972332 0 kegg kegg NA NA no no up no no no Taste transduction Chemokine signaling pathway 0 -0.711462451 -0.487516088 kegg kegg NA NA no no up no no no Taste transduction Cholinergic synapse 0 0 0.488803089 kegg kegg NA NA no no up no no no Taste transduction Circadian entrainment 0 0 -0.458172458 kegg kegg NA NA no no up no up up Taste transduction Circadian rhythm 0 0.498023715 0.677992278 kegg kegg NA NA no no up no no no Taste transduction Citrate cycle (TCA cycle) 0 0.639328063 0.467696268 kegg kegg NA NA no no up no no no Taste transduction Complement and coagulation cascades 0 -0.583992095 -0.637065637 kegg kegg NA NA no no up no no no Taste transduction Cysteine and methionine metabolism 0.726086957 0.595849802 0 kegg kegg NA NA no no up no no no Taste transduction Cytosolic DNA-sensing pathway 0 -0.599802372 0 kegg kegg NA NA no no up no no no Taste transduction DNA replication 0.540869565 0.818181818 0.601029601 kegg kegg NA NA no no up no no no Taste transduction Drug metabolism - cytochrome P450 0 0.636363636 0 kegg kegg NA NA no no up no no no Taste transduction Endocytosis -0.504347826 -0.60770751 0 kegg kegg NA NA no no up no no no Taste transduction ErbB signaling pathway 0 0 0.556241956 kegg kegg NA NA no no up no no no Taste transduction Ether lipid metabolism 0 0.553359684 0.642213642 kegg kegg NA NA no no up no no no Taste transduction Fanconi anemia pathway 0.653913043 0.838932806 0.676705277 kegg kegg NA NA no no up no no no Taste transduction Fc epsilon RI signaling pathway 0 -0.644268775 0 kegg kegg NA NA no no up no no no Taste transduction Fc gamma R-mediated phagocytosis 0 -0.501976285 -0.59021879 kegg kegg NA NA no no up no no no Taste transduction Ferroptosis 0 -0.435770751 -0.653796654 kegg kegg NA NA no no up no no no Taste transduction Folate biosynthesis 0.65826087 0 0 kegg kegg NA NA no no up no no no Taste transduction GABAergic synapse 0 0 -0.539253539 kegg kegg NA NA no no up no up up Taste transduction Galactose metabolism 0 0 0.423938224 kegg kegg NA NA no no up no no no Taste transduction Gap junction 0 0 -0.573745174 kegg kegg NA NA no no up no no no Taste transduction Glutamatergic synapse 0 0 -0.625740026 kegg kegg NA NA no no up no up up Taste transduction Glutathione metabolism 0 0 -0.501930502 kegg kegg NA NA no no up no no no Taste transduction Glycerolipid metabolism 0 0 0.86975547 kegg kegg NA NA no no up no no up Taste transduction Glycerophospholipid metabolism 0 0 0.89009009 kegg kegg NA NA no no up no no up Taste transduction "Glycine, serine and threonine metabolism" 0 0.511857708 -0.475160875 kegg kegg NA NA no no up no up no Taste transduction Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.472173913 0 0 kegg kegg NA NA no no up no no no Taste transduction Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.69009009 kegg kegg NA NA no no up no no no Taste transduction Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.421364221 kegg kegg NA NA no no up no no no Taste transduction Glycosaminoglycan degradation -0.450434783 -0.470355731 0.492149292 kegg kegg NA NA no no up no no up Taste transduction Glycosphingolipid biosynthesis - ganglio series 0 0.563241107 0.497297297 kegg kegg NA NA no no up no no no Taste transduction Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.542608696 0.590909091 0.458687259 kegg kegg NA NA no no up no no no Taste transduction Glyoxylate and dicarboxylate metabolism 0 -0.477272727 -0.52998713 kegg kegg NA NA no no up no no no Taste transduction Hedgehog signaling pathway 0 0.772727273 0.865379665 kegg kegg NA NA no no up no no no Taste transduction Hippo signaling pathway - multiple species 0 0 0.478249678 kegg kegg NA NA no no up no no no Taste transduction Homologous recombination 0.665217391 0.677865613 0.578120978 kegg kegg NA NA no no up no no no Taste transduction IL-17 signaling pathway 0 -0.698616601 -0.595366795 kegg kegg NA NA no no up no no no Taste transduction Inositol phosphate metabolism 0 0 0.885714286 kegg kegg NA NA no no up no no no Taste transduction Intestinal immune network for IgA production -0.572173913 0 0 kegg kegg NA NA no no up no no no Taste transduction Leukocyte transendothelial migration 0 0 -0.450965251 kegg kegg NA NA no no up no no no Taste transduction Linoleic acid metabolism 0 0.516798419 0 kegg kegg NA NA no no up no no no Taste transduction Long-term depression 0 0 -0.424710425 kegg kegg NA NA no no up no no no Taste transduction Long-term potentiation 0.426956522 0.476284585 0.415958816 kegg kegg NA NA no no up no no up Taste transduction Longevity regulating pathway - multiple species 0.622608696 0 0 kegg kegg NA NA no no up no no no Taste transduction Lysine degradation 0 0.423913043 0.86975547 kegg kegg NA NA no no up no no no Taste transduction Lysosome -0.511304348 -0.703557312 0 kegg kegg NA NA no no up no no no Taste transduction Mannose type O-glycan biosynthesis 0 0 0.825225225 kegg kegg NA NA no no up no no no Taste transduction MAPK signaling pathway 0.650434783 0 0.436808237 kegg kegg NA NA no no up no no no Taste transduction Metabolism of xenobiotics by cytochrome P450 0 0.585968379 0 kegg kegg NA NA no no up no no no Taste transduction Mismatch repair 0.548695652 0.82312253 0 kegg kegg NA NA no no up no no no Taste transduction mRNA surveillance pathway 0 0 0.693693694 kegg kegg NA NA no no up no no no Taste transduction Mucin type O-glycan biosynthesis 0.643478261 0 0 kegg kegg NA NA no no up no no no Taste transduction N-Glycan biosynthesis 0.511304348 0.591897233 0.656628057 kegg kegg NA NA no no up no no no Taste transduction Natural killer cell mediated cytotoxicity -0.480869565 -0.613636364 0 kegg kegg NA NA no no up no no no Taste transduction Necroptosis 0 0 -0.647876448 kegg kegg NA NA no no up no no no Taste transduction Neuroactive ligand-receptor interaction 0 -0.517786561 -0.496525097 kegg kegg NA NA no no up up up up Taste transduction Neurotrophin signaling pathway 0 -0.753952569 0 kegg kegg NA NA no no up no no no Taste transduction Neutrophil extracellular trap formation 0 -0.555335968 -0.638867439 kegg kegg NA NA no no up no no no Taste transduction NF-kappa B signaling pathway 0 -0.488142292 0 kegg kegg NA NA no no up no no no Taste transduction Nicotinate and nicotinamide metabolism 0 -0.502964427 -0.429343629 kegg kegg NA NA no no up no no no Taste transduction Nitrogen metabolism 0 -0.502964427 -0.63989704 kegg kegg NA NA no no up no no no Taste transduction NOD-like receptor signaling pathway 0 -0.526679842 0 kegg kegg NA NA no no up no no no Taste transduction Non-homologous end-joining 0 0.433794466 0 kegg kegg NA NA no no up no no no Taste transduction Notch signaling pathway 0 0 0.766537967 kegg kegg NA NA no no up no no no Taste transduction Nucleotide excision repair 0.612173913 0.896245059 0.501415701 kegg kegg NA NA no no up no no no Taste transduction Olfactory transduction 0 0 -0.416731017 kegg kegg NA NA no no up no no no Taste transduction One carbon pool by folate 0.716521739 0.859683794 0.773487773 kegg kegg NA NA no no up no no no Taste transduction Oocyte meiosis 0.59826087 0.440711462 0 kegg kegg NA NA no no up no no no Taste transduction Osteoclast differentiation 0 -0.615612648 -0.520978121 kegg kegg NA NA no no up no no no Taste transduction Other glycan degradation 0 0 0.771685972 kegg kegg NA NA no no up no no no Taste transduction Other types of O-glycan biosynthesis 0 0.495059289 0.872844273 kegg kegg NA NA no no up no no no Taste transduction p53 signaling pathway 0 0 0.504247104 kegg kegg NA NA no no up no no no Taste transduction Pentose and glucuronate interconversions 0.55826087 0.653162055 0.525868726 kegg kegg NA NA no no up no no no Taste transduction Pentose phosphate pathway -0.419130435 -0.639328063 -0.535392535 kegg kegg NA NA no no up no no no Taste transduction Peroxisome 0 0 -0.481081081 kegg kegg NA NA no no up no no no Taste transduction Phagosome -0.56 -0.62055336 -0.528700129 kegg kegg NA NA no no up no no no Taste transduction Phenylalanine metabolism 0 0.656126482 0 kegg kegg NA NA no no up no no no Taste transduction Phosphatidylinositol signaling system 0 0.621541502 0.82007722 kegg kegg NA NA no no up no no no Taste transduction Phospholipase D signaling pathway -0.494782609 -0.448616601 0 kegg kegg NA NA no no up no up up Taste transduction PI3K-Akt signaling pathway 0.560869565 0 0 yes kegg kegg NA NA no no up no up up Taste transduction Platinum drug resistance 0 0.437747036 0.555727156 kegg kegg NA NA no no up no no no Taste transduction Porphyrin and chlorophyll metabolism 0 0 -0.465637066 kegg kegg NA NA no no up no no no Taste transduction PPAR signaling pathway 0 -0.662055336 -0.597425997 kegg kegg NA NA no no up no no no Taste transduction Primary bile acid biosynthesis 0.534782609 0 0 kegg kegg NA NA no no up no no no Taste transduction Propanoate metabolism 0.62173913 0.529644269 0 kegg kegg NA NA no no up no no no Taste transduction Protein export 0 0 0.498841699 kegg kegg NA NA no no up no no no Taste transduction Protein processing in endoplasmic reticulum 0 0.552371542 0 kegg kegg NA NA no no up no no no Taste transduction Purine metabolism 0 0.494071146 -0.423938224 kegg kegg NA NA no no up no no no Taste transduction Pyrimidine metabolism 0 0.686758893 0.40952381 kegg kegg NA NA no no up no no no Taste transduction Pyruvate metabolism 0.640869565 0.586956522 0 kegg kegg NA NA no no up no no no Taste transduction Ras signaling pathway 0 0 0.586100386 yes kegg kegg NA NA no no up no up up Taste transduction Renin-angiotensin system 0 -0.647233202 0 kegg kegg NA NA no no up no no no Taste transduction Retinol metabolism 0.453913043 0.840909091 0.53024453 kegg kegg NA NA no no up no no no Taste transduction Ribosome biogenesis in eukaryotes 0.476521739 0.874505929 0.761904762 kegg kegg NA NA no no up no no no Taste transduction RIG-I-like receptor signaling pathway 0 -0.552371542 0 kegg kegg NA NA no no up no no no Taste transduction RNA degradation 0 0.459486166 0.750836551 kegg kegg NA NA no no up no no no Taste transduction RNA polymerase 0 0.808300395 0.615444015 kegg kegg NA NA no no up no no no Taste transduction Selenocompound metabolism 0 0.682806324 0.816988417 kegg kegg NA NA no no up no no no Taste transduction Serotonergic synapse 0 0 -0.69034749 kegg kegg NA NA no no up no no no Taste transduction Signaling pathways regulating pluripotency of stem cells 0 0 0.681853282 kegg kegg NA NA no no up no no no Taste transduction SNARE interactions in vesicular transport 0 0 0.440926641 kegg kegg NA NA no no up no no no Taste transduction Sphingolipid metabolism -0.539130435 0 0 kegg kegg NA NA no no up no no no Taste transduction Sphingolipid signaling pathway 0 -0.734189723 0 kegg kegg NA NA no no up no no no Taste transduction Spliceosome 0 0.462450593 0.625740026 kegg kegg NA NA no no up no no no Taste transduction Steroid biosynthesis 0.516521739 0.718379447 0.517117117 kegg kegg NA NA no no up no no no Taste transduction Steroid hormone biosynthesis 0 0.684782609 0.514800515 kegg kegg NA NA no no up no no no Taste transduction Sulfur metabolism 0 0 -0.4996139 kegg kegg NA NA no no up no no no Taste transduction Synaptic vesicle cycle 0 -0.441699605 0 kegg kegg NA NA no no up no up up Taste transduction Synthesis and degradation of ketone bodies 0.671304348 0.843873518 0.475160875 kegg kegg NA NA no no up no no no Taste transduction Taurine and hypotaurine metabolism 0 0 0.661003861 kegg kegg NA NA no no up no no no Taste transduction Terpenoid backbone biosynthesis 0.577391304 0.623517787 0.576319176 kegg kegg NA NA no no up no no no Taste transduction TGF-beta signaling pathway 0 0 0.514028314 kegg kegg NA NA no no up no no no Taste transduction Th1 and Th2 cell differentiation -0.507826087 0 0.422136422 kegg kegg NA NA no no up no no no Taste transduction Th17 cell differentiation -0.42173913 0 0.437580438 kegg kegg NA NA no no up no no no Taste transduction Thiamine metabolism 0.54173913 0 0 kegg kegg NA NA no no up no no no Taste transduction Tight junction 0 0 -0.43011583 kegg kegg NA NA no no up no no no Taste transduction TNF signaling pathway 0 -0.626482213 0 kegg kegg NA NA no no up no no no Taste transduction Toll-like receptor signaling pathway -0.407826087 -0.743083004 0 yes kegg kegg NA NA no no up no no no Taste transduction Tryptophan metabolism 0 0.523715415 0 kegg kegg NA NA no no up no up no Taste transduction Tyrosine metabolism 0 0.773715415 0 kegg kegg NA NA no no up no no no Taste transduction Ubiquinone and other terpenoid-quinone biosynthesis 0.511304348 0.824110672 0.473101673 kegg kegg NA NA no no up no no no Taste transduction "Valine, leucine and isoleucine degradation" 0.42 0.766798419 0.40952381 kegg kegg NA NA no no up no no no Taste transduction Various types of N-glycan biosynthesis 0.414782609 0.476284585 0.614157014 kegg kegg NA NA no no up no no no Taste transduction VEGF signaling pathway 0 -0.555335968 0.418018018 kegg kegg NA NA no no up no no no Taste transduction Viral protein interaction with cytokine and cytokine receptor 0 -0.414031621 -0.526383526 kegg kegg NA NA no no up no no no Taste transduction Wnt signaling pathway 0 0.550395257 0.758043758 kegg kegg NA NA no no up no no no Taurine and hypotaurine metabolism beta-Alanine metabolism 0 -0.505928854 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Citrate cycle (TCA cycle) 0 -0.513833992 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Cysteine and methionine metabolism 0 -0.549407115 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Fatty acid elongation 0 -0.700592885 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Fructose and mannose metabolism 0 0.681818182 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Galactose metabolism 0 0.475296443 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Glycolysis / Gluconeogenesis 0 -0.768774704 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Lysine degradation 0.414782609 0.649209486 0.592792793 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Oxidative phosphorylation 0 -0.43083004 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Phenylalanine metabolism 0 -0.445652174 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Primary bile acid biosynthesis 0 -0.640316206 0 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Pyrimidine metabolism 0 0 0.511454311 kegg kegg NA NA no no no no no no Taurine and hypotaurine metabolism Tryptophan metabolism 0 -0.550395257 0 kegg kegg NA NA no no no no up no Taurine+blood 13-HODE+blood 0 0.678921569 0 serum_aminoacids serum_ARA 0.857 0.32 no no no no no no Taurine+blood 14:0/16:0-PC+blood 0 -0.56127451 0 serum_aminoacids serum_phospholipids 0.857 0.0358 no no no no up no Taurine+blood 14:0/20:4-PC+blood 0 0 -0.405128205 serum_aminoacids serum_phospholipids 0.857 0.486 no no no no no no Taurine+blood 16:0/16:1-PI+blood 0 -0.49754902 0 serum_aminoacids serum_phospholipids 0.857 0.262 no no no no no no Taurine+blood 16:0/18:0-PS+blood 0 -0.512254902 0 serum_aminoacids serum_phospholipids 0.857 0.377 no no no no no no Taurine+blood 16:0/18:2-PC+blood 0 0.539215686 0 serum_aminoacids serum_phospholipids 0.857 3.24E-06 no no no no up up Taurine+blood 16:0/20:4-PC+blood 0.446616541 0 0 serum_aminoacids serum_phospholipids 0.857 0.0262 no no no no up no Taurine+blood 16:0/20:4-PI+blood 0 -0.571078431 0 serum_aminoacids serum_phospholipids 0.857 0.558 no no no no no no Taurine+blood 18:0-LPA+blood 0.583458647 0 0 serum_aminoacids serum_phospholipids 0.857 0.0725 no no no no dn no Taurine+blood 18:0-LPC+blood -0.589473684 0 0 serum_aminoacids serum_phospholipids 0.857 0.554 no no no no no no Taurine+blood 18:0/18:0-PS+blood 0 -0.669117647 0 serum_aminoacids serum_phospholipids 0.857 0.00617 no no no no up no Taurine+blood 18:0/18:1-PG+blood 0 -0.68627451 0 serum_aminoacids serum_phospholipids 0.857 0.000842 no no no no up no Taurine+blood 18:0/20:3-PC+blood -0.589473684 0 0 serum_aminoacids serum_phospholipids 0.857 0.0682 no no no no up no Taurine+blood 18:0+blood -0.473684211 0 0 serum_aminoacids serum_fattyacid 0.857 0.344 no no no no no no Taurine+blood 18:1/16:0-PC+blood 0 0.588235294 0 serum_aminoacids serum_phospholipids 0.857 2.43E-05 no no no no up up Taurine+blood 18:2/16:0-PC+blood 0 0.485294118 0 serum_aminoacids serum_phospholipids 0.857 8.67E-05 no no no no up up Taurine+blood 18:3n6+blood 0 -0.703431373 0 serum_aminoacids serum_fattyacid 0.857 0.0463 no no no up no dn Taurine+blood 20:0/20:4-PE+blood 0 -0.504901961 -0.422222222 serum_aminoacids serum_phospholipids 0.857 0.00128 no no no up up no Taurine+blood 20:1-LPE+blood 0 0 -0.422905983 serum_aminoacids serum_phospholipids 0.857 0.465 no no no no no no Taurine+blood 20:1/20:4-PE+blood 0 -0.625 0 serum_aminoacids serum_phospholipids 0.857 0.0042 no no no up up no Taurine+blood 20:2-LPC+blood 0 0.610294118 0 serum_aminoacids serum_phospholipids 0.857 0.119 no no no no no up Taurine+blood 20:2/18:0-PC+blood -0.578947368 0 0 serum_aminoacids serum_phospholipids 0.857 0.0427 no no no no up no Taurine+blood 20:4-LPE+blood 0 0 -0.421538462 serum_aminoacids serum_phospholipids 0.857 0.552 no no no no no no Taurine+blood 20:4/18:0-PE+blood 0.476691729 0 0 serum_aminoacids serum_phospholipids 0.857 0.000755 no no no up up no Taurine+blood 20:5-LPC+blood 0 0 0.491965812 serum_aminoacids serum_phospholipids 0.857 0.558 no no no no no no Taurine+blood 22:2-LPA+blood 0.508270677 0 0 serum_aminoacids serum_phospholipids 0.857 0.0443 no no no dn no no Taurine+blood 22:6-LPC+blood -0.446616541 0 0.594529915 serum_aminoacids serum_phospholipids 0.857 0.127 no no no no no up Taurine+blood 22:6n3+blood -0.473684211 0 0.474871795 serum_aminoacids serum_fattyacid 0.857 0.792 no no no no no no Taurine+blood 8-HETE+blood 0.50075188 0.81372549 0 serum_aminoacids serum_ARA 0.857 0.741 no no no no no no Taurine+blood Acute myeloid leukemia 0 0 0.537692308 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Adherens junction 0.59122807 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Adipocytokine signaling pathway 0 0.541176471 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Alcoholism -0.461403509 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Allograft rejection 0 0 -0.466153846 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Apoptosis 0.531578947 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Arrhythmogenic right ventricular cardiomyopathy 0.570175439 0 0 serum_aminoacids kegg 0.857 NA no no no no up up Taurine+blood Autoimmune thyroid disease 0 0 -0.466153846 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood B cell receptor signaling pathway 0 0.508823529 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Bacterial invasion of epithelial cells 0.524561404 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Cell adhesion molecules 0 0 -0.478461538 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Cellular senescence 0 0 -0.51 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Central carbon metabolism in cancer 0 -0.505882353 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Chemokine signaling pathway 0 0.591176471 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Choline+blood 0 0.5 0 serum_aminoacids serum_choline 0.857 0.0395 no no no no up no Taurine+blood Cholinergic synapse -0.514035088 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Chronic myeloid leukemia 0 0.502941176 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Cysteine+blood 0 0 0.558290598 yes serum_aminoacids serum_aminoacids 0.857 1.81E-07 no no no dn up up Taurine+blood Cystine+blood 0 0 0.473504274 yes serum_aminoacids serum_aminoacids 0.857 0.00028 no no no up up no Taurine+blood d18:1-14:0-SM+blood 0 -0.68872549 0 serum_aminoacids serum_phospholipids 0.857 0.94 no no no no no no Taurine+blood d18:1-14:1-SM+blood 0 -0.509803922 0 serum_aminoacids serum_phospholipids 0.857 0.0952 no no no no dn no Taurine+blood Dilated cardiomyopathy 0.470175439 0 0 serum_aminoacids kegg 0.857 NA no no no no up up Taurine+blood DL-methionine sulfoxide+blood 0 0 0.562393162 serum_aminoacids serum_aminoacids 0.857 0.302 no no no no no no Taurine+blood Epithelial cell signaling in Helicobacter pylori infection 0 0.564705882 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Ethanolamine+blood 0.580451128 0.693627451 0 serum_aminoacids serum_aminoacids 0.857 0.122 no no no up no no Taurine+blood Fluid shear stress and atherosclerosis 0.459649123 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Focal adhesion 0.50877193 0 0 serum_aminoacids kegg 0.857 NA no no no no up up Taurine+blood GABAergic synapse -0.531578947 0 0 serum_aminoacids kegg 0.857 NA no no no no up up Taurine+blood Glucagon signaling pathway -0.468421053 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Glutamatergic synapse -0.466666667 0 0 serum_aminoacids kegg 0.857 NA no no no no up up Taurine+blood Glycine+blood 0.518796992 0.75 0 serum_aminoacids serum_aminoacids 0.857 0.00408 no no no dn no up Taurine+blood GnRH signaling pathway -0.640350877 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood GPC+blood 0 0.651960784 0 serum_aminoacids serum_choline 0.857 0.00427 no no no no up up Taurine+blood Graft-versus-host disease 0 0 -0.459230769 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Hepatocellular carcinoma 0.538596491 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Hippo signaling pathway 0.545614035 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Human T-cell leukemia virus 1 infection 0 0 -0.408461538 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Hypertrophic cardiomyopathy 0.561403509 0 0 serum_aminoacids kegg 0.857 NA no no no no up up Taurine+blood Hypotaurine+blood 0.616541353 0.68872549 0 serum_aminoacids serum_aminoacids 0.857 0.933 no no no no no no Taurine+blood Influenza A 0.459649123 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood L-Asparagine+blood 0 0.75 0 serum_aminoacids serum_aminoacids 0.857 0.784 no no no no no no Taurine+blood L-Aspartic acid+blood 0.461654135 0.725490196 0 yes serum_aminoacids serum_aminoacids 0.857 0.0226 no no no up up no Taurine+blood L-Citrulline+blood 0 0.534313725 0 serum_aminoacids serum_aminoacids 0.857 0.534 no no no no no no Taurine+blood L-Glutamine+blood 0 0.556372549 0 serum_aminoacids serum_aminoacids 0.857 0.639 no no no no no no Taurine+blood L-Histidine+blood 0 0.647058824 0 serum_aminoacids serum_aminoacids 0.857 0.109 no no no no no no Taurine+blood L-Isoleucine+blood 0 0 0.551452991 yes serum_aminoacids serum_aminoacids 0.857 5.47E-06 no no no up up no Taurine+blood L-Lysine+blood 0 0.5 0.472820513 yes serum_aminoacids serum_aminoacids 0.857 0.0107 no no no no up no Taurine+blood L-Methionine+blood 0 0 0.428376068 serum_aminoacids serum_aminoacids 0.857 0.626 no no no no no no Taurine+blood L-Ornithine+blood 0 0.482843137 0.475555556 serum_aminoacids serum_aminoacids 0.857 0.175 no no no no no no Taurine+blood L-Phenylalanine+blood 0 0 0.682051282 yes serum_aminoacids serum_aminoacids 0.857 0.0103 no no no up up no Taurine+blood L-Threonine+blood 0 0.487745098 0 serum_aminoacids serum_aminoacids 0.857 0.0538 no no no dn no up Taurine+blood Leukocyte transendothelial migration 0.5 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Long-term potentiation -0.559649123 0 0 serum_aminoacids kegg 0.857 NA no no no no no up Taurine+blood n3+blood 0 0 0.562393162 serum_aminoacids serum_fattyacid 0.857 0.806 no no no no no no Taurine+blood Oocyte meiosis 0 -0.588235294 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Oxytocin signaling pathway 0.492982456 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood p53 signaling pathway -0.524561404 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Paraprevotella 0.519368197 0 0 serum_aminoacids Genus 0.857 0.118 no no no no no no Taurine+blood Pathogenic Escherichia coli infection 0.756140351 0.502941176 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Phosphatidylinositol signaling system 0 -0.570588235 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Platinum drug resistance -0.529824561 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Prevotella 0.493567647 0 0 serum_aminoacids Genus 0.857 0.367 no no no no no no Taurine+blood Prostate cancer 0 0.529411765 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood PUFA/MUFA+blood 0 0.583333333 0 serum_aminoacids serum_fattyacid 0.857 0.00108 no no no dn no up Taurine+blood PUFA/UFA+blood 0 0.661764706 0 serum_aminoacids serum_fattyacid 0.857 0.000732 no no no dn no up Taurine+blood PUFA%+blood 0 0.674019608 0 serum_aminoacids serum_fattyacid 0.857 0.0013 no no no dn no up Taurine+blood Rap1 signaling pathway 0.573684211 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Regulation of actin cytoskeleton 0.496491228 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Relaxin signaling pathway 0 0.538235294 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Salmonella infection 0.554385965 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Serine+blood 0 0.607843137 0 serum_aminoacids serum_aminoacids 0.857 0.942 no no no no no no Taurine+blood Thyroid hormone signaling pathway 0.456140351 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Tight junction 0.522807018 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood TNF signaling pathway 0 0.535294118 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Type I diabetes mellitus 0 0 -0.472307692 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Vibrio cholerae infection 0.577192982 0 0 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Viral carcinogenesis 0 0 -0.436153846 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Viral myocarditis 0.485964912 0 -0.417692308 serum_aminoacids kegg 0.857 NA no no no no no no Taurine+blood Yersinia infection 0.585964912 0 0 serum_aminoacids kegg 0.857 NA no no no no no no TBIL+clinic 13-HODE+blood 0 0.635714286 0 clinic serum_ARA 0.171 0.32 no no no no no no TBIL+clinic 14:0/18:2-PC+blood 0 0 -0.526153846 clinic serum_phospholipids 0.171 0.102 no no no no up no TBIL+clinic 14:0/20:4-PC+blood 0 0 -0.622307692 clinic serum_phospholipids 0.171 0.486 no no no no no no TBIL+clinic 16:0/18:2-PI+blood 0 0 -0.513846154 clinic serum_phospholipids 0.171 0.269 no no no no no no TBIL+clinic 16:0/20:4-PI+blood 0 0 -0.463076923 clinic serum_phospholipids 0.171 0.558 no no no no no no TBIL+clinic 16:0/22:6-PC+blood 0 0 0.435384615 clinic serum_phospholipids 0.171 4.53E-05 no no no no up up TBIL+clinic 16:1/16:0-PC+blood 0 0.557142857 0.456923077 clinic serum_phospholipids 0.171 0.0215 no no no no up up TBIL+clinic 18:0/18:0-PS+blood 0 -0.517857143 0 clinic serum_phospholipids 0.171 0.00617 no no no no up no TBIL+clinic 18:1/16:0-PC+blood 0 0 0.406153846 clinic serum_phospholipids 0.171 2.43E-05 no no no no up up TBIL+clinic 18:2/16:0-PC+blood 0 0.610714286 0 clinic serum_phospholipids 0.171 8.67E-05 no no no no up up TBIL+clinic 18:3n6+blood 0 -0.528571429 -0.56 clinic serum_fattyacid 0.171 0.0463 no no no up no dn TBIL+clinic 20:3n6+blood 0 0 -0.472307692 clinic serum_fattyacid 0.171 0.0884 no no no up no no TBIL+clinic 8-HETE+blood 0 0.7 0 clinic serum_ARA 0.171 0.741 no no no no no no TBIL+clinic Betaine+blood 0 0 0.424615385 clinic serum_choline 0.171 0.857 no no no no no no TBIL+clinic Central carbon metabolism in cancer 0 -0.593506494 0 clinic kegg 0.171 NA no no no no no no TBIL+clinic Coronavirus disease - COVID-19 0 -0.450649351 0 clinic kegg 0.171 NA no no no no no no TBIL+clinic Creatinine+blood 0 0 0.662307692 clinic serum_choline 0.171 0.437 no no no no no no TBIL+clinic d18:1-14:0-SM+blood 0 -0.542857143 0 clinic serum_phospholipids 0.171 0.94 no no no no no no TBIL+clinic d18:1-16:1-SM+blood 0 0 -0.473076923 clinic serum_phospholipids 0.171 0.2 no no no no no no TBIL+clinic d18:1-22:1-SM+blood 0 0 -0.443076923 clinic serum_phospholipids 0.171 0.222 no no no no no no TBIL+clinic Eotaxin 0 0.489473684 0 clinic serum_cytokines 0.171 0.393 no no no no no no TBIL+clinic GDCA+stool 0 0 -0.456933088 clinic stool_bileacids 0.171 0.656 no no no no no no TBIL+clinic HIF-1 signaling pathway 0 -0.477922078 0 clinic kegg 0.171 NA no no no no no no TBIL+clinic IL-9 0 0.610526316 0 clinic serum_cytokines 0.171 0.906 no no no no no no TBIL+clinic Insulin signaling pathway 0 -0.448051948 0 clinic kegg 0.171 NA no no no no no no TBIL+clinic L-Asparagine+blood 0 0 0.696153846 clinic serum_aminoacids 0.171 0.784 no no no no no no TBIL+clinic L-Glutamine+blood 0 0 0.719230769 clinic serum_aminoacids 0.171 0.639 no no no no no no TBIL+clinic L-Histidine+blood 0 0 0.555384615 clinic serum_aminoacids 0.171 0.109 no no no no no no TBIL+clinic Legionellosis 0 -0.454545455 0 clinic kegg 0.171 NA no no no no no no TBIL+clinic Leptin 0 0 -0.462796028 clinic DM-assocaited hormones 0.171 0.706 no no no no no no TBIL+clinic MUFA%+blood 0 0 0.500769231 clinic serum_fattyacid 0.171 0.00142 no no no up no dn TBIL+clinic n6+blood 0 0 -0.400769231 clinic serum_fattyacid 0.171 0.153 no no no no no no TBIL+clinic nutriCA+stool 0 -0.642370687 0 clinic stool_bileacids 0.171 0.481 no no no no no no TBIL+clinic Phenylacetyl L-GlutaMine+urine 0 0.487745098 0 clinic urine_cometabolism 0.171 0.0909 no no no up no no TBIL+clinic PUFA%+blood 0 0 0.460769231 clinic serum_fattyacid 0.171 0.0013 no no no dn no up TBIL+clinic RANTES 0 0.559649123 0 yes clinic serum_cytokines 0.171 0.0757 no no no no no up TBIL+clinic Renal cell carcinoma 0 -0.463636364 0 clinic kegg 0.171 NA no no no no no no TBIL+clinic Ribosome 0 -0.446753247 0 clinic kegg 0.171 NA no no no no no no TBIL+clinic Serine+blood 0 0 0.523846154 clinic serum_aminoacids 0.171 0.942 no no no no no no TBIL+clinic SFA%+blood 0 0 0.507692308 clinic serum_fattyacid 0.171 0.0236 no no no no up no TBIL+clinic Taurine+blood 0 0.682142857 0 clinic serum_aminoacids 0.171 0.857 no no no no no no TBIL+clinic TXB2+blood 0 0.621521613 0 yes clinic serum_ARA 0.171 0.0644 no no no dn no no TBIL+clinic UFA%+blood 0 0 0.537692308 clinic serum_fattyacid 0.171 0.0236 no no no no dn no TCA+blood 12-ketoDCA+stool 0 0.650492813 0 serum_bileacids stool_bileacids 0.339 0.505 no no no no no no TCA+blood 15-HETE+blood -0.465445979 0 0 serum_bileacids serum_ARA 0.339 0.819 no no no no no no TCA+blood 16:0/16:0-PI+blood 0 0.490157248 0 serum_bileacids serum_phospholipids 0.339 0.358 no no no no no no TCA+blood 16:0/22:6-PC+blood 0 -0.485077898 0 serum_bileacids serum_phospholipids 0.339 4.53E-05 no no no no up up TCA+blood 18:0/16:0-PC+blood -0.463509693 0 0 serum_bileacids serum_phospholipids 0.339 9.64E-07 no no no up up up TCA+blood 18:0/18:2-PI+blood 0 -0.525712696 0 serum_bileacids serum_phospholipids 0.339 0.179 no no no no no no TCA+blood 18:0/20:2-PC+blood 0.479275329 0 0 serum_bileacids serum_phospholipids 0.339 0.733 no no no no no no TCA+blood 18:0/20:3-PC+blood 0.509230037 0 0 serum_bileacids serum_phospholipids 0.339 0.0682 no no no no up no TCA+blood 18:0/20:4-PI+blood 0 -0.485077898 0 serum_bileacids serum_phospholipids 0.339 0.167 no no no no no no TCA+blood 20:1-LPE+blood 0 -0.513014322 0 serum_bileacids serum_phospholipids 0.339 0.465 no no no no no no TCA+blood 20:2/18:0-PC+blood 0.502923782 0 0 serum_bileacids serum_phospholipids 0.339 0.0427 no no no no up no TCA+blood 20:3/18:0-PC+blood 0 -0.490157248 0 serum_bileacids serum_phospholipids 0.339 0.296 no no no no no no TCA+blood 20:3n6+blood 0.529725363 0 0 serum_bileacids serum_fattyacid 0.339 0.0884 no no no up no no TCA+blood 20:4-LPA+blood -0.518689418 0 0.402918348 serum_bileacids serum_phospholipids 0.339 0.398 no no no no no no TCA+blood 20:4-LPE+blood -0.520265982 0 0 serum_bileacids serum_phospholipids 0.339 0.552 no no no no no no TCA+blood 20:4n6+blood -0.542337872 0 0 serum_bileacids serum_fattyacid 0.339 0.133 no no no no no no TCA+blood 20:5-LPC+blood 0 0 -0.542805051 serum_bileacids serum_phospholipids 0.339 0.558 no no no no no no TCA+blood 20:5/18:0-PC+blood 0 -0.594283918 0 serum_bileacids serum_phospholipids 0.339 3.97E-06 no no no no up up TCA+blood 22:6-LPC+blood 0 0 -0.437890024 serum_bileacids serum_phospholipids 0.339 0.127 no no no no no up TCA+blood 5-HETE+blood -0.570499954 0 0 serum_bileacids serum_ARA 0.339 0.697 no no no no no no TCA+blood Alcoholism 0 -0.509672654 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Allograft rejection 0 -0.518883606 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Amphetamine addiction 0 0.518883606 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Autoimmune thyroid disease 0 -0.518883606 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Biosynthesis of amino acids 0 -0.506602337 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Cell adhesion molecules 0 -0.537305509 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Cellular senescence 0 -0.614063438 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Clostridium 0.477089874 0 0 serum_bileacids Genus 0.339 0.925 no no no no no no TCA+blood d18:0-16:0-SM+blood -0.457203438 0 0 serum_bileacids serum_phospholipids 0.339 0.202 no no no no no no TCA+blood d18:1-16:0-SM+blood -0.474545638 0 0 serum_bileacids serum_phospholipids 0.339 0.14 no no no no no no TCA+blood d18:1-18:0-SM+blood -0.523419109 0 0 serum_bileacids serum_phospholipids 0.339 0.97 no no no no no no TCA+blood d18:1-18:1-SM+blood -0.526572236 0 0 serum_bileacids serum_phospholipids 0.339 0.916 no no no no no no TCA+blood d18:1-20:1-SM+blood -0.465086256 0 0 serum_bileacids serum_phospholipids 0.339 0.0992 no no no no no no TCA+blood DCA+blood 0 0 -0.428961085 serum_bileacids serum_bileacids 0.339 0.122 no no no no no no TCA+blood DHA+blood 0 0 -0.53908466 serum_bileacids serum_ARA 0.339 0.872 no no no no no no TCA+blood DPA+blood 0 0 -0.411847287 serum_bileacids serum_ARA 0.339 0.519 no no no no no no TCA+blood Endocytosis 0 -0.598711853 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood EPA+blood 0 0 -0.506345219 serum_bileacids serum_ARA 0.339 0.212 no no no no no no TCA+blood Fluid shear stress and atherosclerosis -0.523029991 0 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Focal adhesion -0.545286586 0 0 serum_bileacids kegg 0.339 NA no no no no up up TCA+blood Gastric acid secretion -0.4785168 0 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood GCA+blood 0.476122201 0.911743275 0.649952312 yes serum_bileacids serum_bileacids 0.339 0.16 no no no no no no TCA+blood GCDCA+blood 0 0.72634701 0 serum_bileacids serum_bileacids 0.339 0.31 no no no no no no TCA+blood Graft-versus-host disease 0 -0.518883606 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood GUDCA+blood 0 0.490157248 0 serum_bileacids serum_bileacids 0.339 0.0766 no no no no no dn TCA+blood Hepatocellular carcinoma -0.461824354 0 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Hippo signaling pathway -0.508192261 0 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Human papillomavirus infection 0 -0.641696293 -0.418059367 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood L-2-Aminobutyric acid+blood 0 0 0.456864018 yes serum_bileacids serum_aminoacids 0.339 0.000328 no no no up up no TCA+blood L-Arginine+blood 0.465086256 0 0 serum_bileacids serum_aminoacids 0.339 0.316 no no no no no no TCA+blood Leukocyte transendothelial migration -0.471097935 0 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Methanobrevibacter 0 0.575846774 0 serum_bileacids Genus 0.339 0.629 no no no no no no TCA+blood Natural killer cell mediated cytotoxicity 0 -0.589500901 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Oxytocin signaling pathway -0.472952651 0 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Pathogenic Escherichia coli infection -0.524884707 0 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Platelet activation -0.467388503 0 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Porphyrin and chlorophyll metabolism 0 0.518883606 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Rap1 signaling pathway -0.495209247 0 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Regulation of actin cytoskeleton -0.523029991 0 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Salmonella infection -0.497063963 0 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Systemic lupus erythematosus 0 0 0.408105572 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Taurine+blood -0.610130106 0 0 serum_bileacids serum_aminoacids 0.339 0.857 no no no no no no TCA+blood Thyroid hormone signaling pathway -0.530448856 0 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Type I diabetes mellitus 0 -0.518883606 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Vibrio cholerae infection -0.469243219 0 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+blood Viral carcinogenesis 0 -0.592571218 0 serum_bileacids kegg 0.339 NA no no no no no no TCA+stool Adherens junction 0 0.756266199 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Alzheimer disease 0 0.678817251 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Amyotrophic lateral sclerosis 0 0.605924123 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Anaerostipes 0.585492228 0 0 butyrate-producing stool_bileacids Genus 0.458 0.568 no no no no no no TCA+stool Arginine and proline metabolism 0.476733181 0 0 stool_bileacids kegg 0.458 NA no no no no up no TCA+stool Arrhythmogenic right ventricular cardiomyopathy 0 0.719819635 0 stool_bileacids kegg 0.458 NA no no no no up up TCA+stool Bacterial invasion of epithelial cells 0 0.815491865 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool CA+stool 0 0 0.523715415 stool_bileacids stool_bileacids 0.458 0.827 no no no no no no TCA+stool Caproic acid+stool 0 -0.588442233 0 stool_bileacids stool_scfa 0.458 0.882 no no no no no no TCA+stool CDCA+stool 0 0 0.432806324 stool_bileacids stool_bileacids 0.458 0.663 no no no no no no TCA+stool Cholinergic synapse 0 -0.651482328 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Coprococcus 0.526371343 0 -0.59486166 butyrate-producing stool_bileacids Genus 0.458 0.612 no no no no no no TCA+stool DCA+stool 0 0 -0.531620553 stool_bileacids stool_bileacids 0.458 0.195 no no no no no no TCA+stool Diabetic cardiomyopathy 0 0.678817251 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool ErbB signaling pathway 0 -0.66970561 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Fluid shear stress and atherosclerosis 0 0.779045301 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Focal adhesion 0 0.724375456 0 stool_bileacids kegg 0.458 NA no no no no up up TCA+stool FoxO signaling pathway 0 -0.751710379 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool GCA+stool 0 0 0.590909091 stool_bileacids stool_bileacids 0.458 0.0809 no no no no no no TCA+stool GCDCA+stool 0 0 0.473320158 yes stool_bileacids stool_bileacids 0.458 0.0471 no no no no dn no TCA+stool GDCA+stool 0 0 0.487636242 stool_bileacids stool_bileacids 0.458 0.656 no no no no no no TCA+stool Hepatocellular carcinoma 0 0.742598738 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Hippo signaling pathway 0 0.715263815 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Huntington disease 0 0.678817251 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Hypertrophic cardiomyopathy 0 0.710707994 0 stool_bileacids kegg 0.458 NA no no no no up up TCA+stool iso-LCA+stool 0 -0.581436969 -0.427865613 stool_bileacids stool_bileacids 0.458 0.72 no no no no no no TCA+stool JAK-STAT signaling pathway 0 -0.605924123 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Lachnospira 0 0.584939601 0 butyrate-producing stool_bileacids Genus 0.458 0.279 no no no no no no TCA+stool LCA+stool -0.524303086 0 -0.447628458 stool_bileacids stool_bileacids 0.458 0.314 no no no no no no TCA+stool Leukocyte transendothelial migration 0 0.774489481 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Longevity regulating pathway - multiple species 0.551190424 0 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool MAPK signaling pathway 0 -0.833715147 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Non-alcoholic fatty liver disease 0 0.697040533 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Olfactory transduction 0.542917397 0 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Oxidative phosphorylation 0 0.678817251 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Oxytocin signaling pathway 0 0.815491865 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Parabacteroides 0 -0.588442233 -0.451581028 stool_bileacids Genus 0.458 4.19E-05 no no no no up up TCA+stool Parkinson disease 0 0.687928892 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Pathways of neurodegeneration - multiple diseases 0 0.651482328 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Peroxisome 0.563599964 0 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Platelet activation 0 0.838270968 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Platinum drug resistance 0 -0.710707994 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Primary immunodeficiency 0.470528411 0 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Prion disease 0 0.683373071 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Progesterone-mediated oocyte maturation 0 -0.665149789 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Propionic acid+stool 0 0 -0.530632411 yes stool_bileacids stool_scfa 0.458 0.0436 no no no dn no up TCA+stool Rap1 signaling pathway 0 0.824603506 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Retrograde endocannabinoid signaling 0 0.692484712 0 stool_bileacids kegg 0.458 NA no no no no no up TCA+stool Ruminococcus 0 0 -0.455449543 stool_bileacids Genus 0.458 0.0679 no no no no no dn TCA+stool Ruminococcus -0.472596667 0 0 acetate-producing stool_bileacids Genus 0.458 0.335 no no no no no no TCA+stool Signaling pathways regulating pluripotency of stem cells 0 0 -0.471485037 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Spliceosome 0 -0.742598738 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool T cell receptor signaling pathway 0 -0.76537784 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool T-¦Á-MCA+stool 0 0 -0.591949453 stool_bileacids stool_bileacids 0.458 0.48 no no no no no no TCA+stool Th1 and Th2 cell differentiation -0.544985654 0 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Th17 cell differentiation -0.5284396 0 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Thermogenesis 0 0.642370687 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Tight junction 0 0.86105007 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Vascular smooth muscle contraction 0 0.678817251 0 stool_bileacids kegg 0.458 NA no no no no no no TCA+stool Vibrio cholerae infection 0 0.701596353 0 stool_bileacids kegg 0.458 NA no no no no no no TDCA+blood 12-ketoDCA+blood 0.585191892 0 0.441703189 yes serum_bileacids serum_bileacids 0.155 0.517 no up no no no no TDCA+blood 14:0-LPC+blood 0 0.681900196 0 yes serum_bileacids serum_phospholipids 0.155 0.00689 no up no up up no TDCA+blood 14:0/18:0-PC+blood 0.488152779 0 0 yes serum_bileacids serum_phospholipids 0.155 0.00289 no up no up up no TDCA+blood 14:0+blood -0.456531546 0 0 yes yes serum_bileacids serum_fattyacid 0.155 0.00572 no up no up no dn TDCA+blood 15-HETE+blood -0.495847733 0 0 yes serum_bileacids serum_ARA 0.155 0.819 no up no no no no TDCA+blood 16:0-LPE+blood 0.472342162 0 0 yes serum_bileacids serum_phospholipids 0.155 0.0711 no up no up up no TDCA+blood 16:0/16:1-PC+blood 0.446649911 0 0 yes serum_bileacids serum_phospholipids 0.155 0.00283 no up no up up no TDCA+blood 16:0/18:1-PC+blood 0 -0.506280025 0 yes serum_bileacids serum_phospholipids 0.155 6.15E-07 no up no up up up TDCA+blood 16:0/20:4-PE+blood 0.507916049 0 0 yes serum_bileacids serum_phospholipids 0.155 0.00139 no up no up up no TDCA+blood 16:1/16:0-PC+blood 0 -0.526860513 0 yes serum_bileacids serum_phospholipids 0.155 0.0215 no up no no up up TDCA+blood 16:1/18:1-PG+blood 0 -0.540580839 0 yes serum_bileacids serum_phospholipids 0.155 3.21E-05 no up no no up up TDCA+blood 16:1/18:2-PG+blood 0 0 -0.414881707 yes serum_bileacids serum_phospholipids 0.155 1.40E-08 no up no no up up TDCA+blood 18:0/16:0-PC+blood 0 -0.504907992 0 yes serum_bileacids serum_phospholipids 0.155 9.64E-07 no up no up up up TDCA+blood 18:0/18:0-PC+blood 0 -0.488443601 0 yes serum_bileacids serum_phospholipids 0.155 0.426 no up no no no no TDCA+blood 18:0/18:0-PS+blood 0 0 -0.430524205 yes serum_bileacids serum_phospholipids 0.155 0.00617 no up no no up no TDCA+blood 18:0/22:6-PA+blood 0 -0.573509621 0 yes serum_bileacids serum_phospholipids 0.155 0.22 no up no no no no TDCA+blood 18:0/22:6-PC+blood 0 -0.532348644 0 yes serum_bileacids serum_phospholipids 0.155 0.0775 no up no no no up TDCA+blood 18:0/22:6-PI+blood 0 -0.533720676 0 yes serum_bileacids serum_phospholipids 0.155 0.425 no up no no no no TDCA+blood 18:1/18:0-PI+blood 0 0 -0.40492739 yes serum_bileacids serum_phospholipids 0.155 0.0931 no up no no no up TDCA+blood 18:1/18:1-PG+blood 0 0 -0.495938287 yes serum_bileacids serum_phospholipids 0.155 0.00352 no up no no up up TDCA+blood 18:1/18:2-PG+blood 0 0 -0.56704055 yes serum_bileacids serum_phospholipids 0.155 5.58E-07 no up no no up up TDCA+blood 18:1/18:2-PI+blood -0.484200125 0 0 yes serum_bileacids serum_phospholipids 0.155 0.0164 no up no dn no up TDCA+blood 18:2/20:4-PC+blood -0.466413181 0 0 yes serum_bileacids serum_phospholipids 0.155 0.0145 no up no no no up TDCA+blood 18:3n3+blood -0.464436854 0 0 yes serum_bileacids serum_fattyacid 0.155 0.291 no up no no no no TDCA+blood 20:0/20:4-PE+blood 0 0.529604579 0 yes serum_bileacids serum_phospholipids 0.155 0.00128 no up no up up no TDCA+blood 20:1/20:4-PC+blood 0 -0.681900196 0 yes serum_bileacids serum_phospholipids 0.155 0.0419 no up no no no up TDCA+blood 20:3/18:0-PC+blood 0 -0.584485882 0 yes serum_bileacids serum_phospholipids 0.155 0.296 no up no no no no TDCA+blood 20:5/18:0-PC+blood -0.456531546 -0.504907992 0 yes serum_bileacids serum_phospholipids 0.155 3.97E-06 no up no no up up TDCA+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 -0.474764175 yes serum_bileacids stool_cometabolism 0.155 0.33 no up no no no no TDCA+blood 5-HETE+blood 0 -0.668963416 0 yes serum_bileacids serum_ARA 0.155 0.697 no up no no no no TDCA+blood 9-HODE+blood -0.501987068 0 0 yes serum_bileacids serum_ARA 0.155 0.297 no up no no no no TDCA+blood AA+blood -0.557324225 0 0 yes serum_bileacids serum_ARA 0.155 0.212 no up no no no no TDCA+blood AMPK signaling pathway 0.599760912 0.582989891 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Anaerostipes 0 -0.589998362 0 yes butyrate-producing serum_bileacids Genus 0.155 0.568 no up no no no no TDCA+blood Bifidobacterium -0.508107103 0 0 yes acetate-producing serum_bileacids Genus 0.155 0.105 no up no no dn no TDCA+blood Blautia 0 -0.550185067 0 yes acetate-producing serum_bileacids Genus 0.155 1.36E-05 no up no up dn dn TDCA+blood Butyricimonas -0.48025967 0 0 yes butyrate-producing serum_bileacids Genus 0.155 0.17 no up no no no no TDCA+blood CA+blood 0 0.565624115 0 yes serum_bileacids serum_bileacids 0.155 0.606 no up no no no no TDCA+blood CDCA+stool 0 0 -0.476300629 yes serum_bileacids stool_bileacids 0.155 0.663 no up no no no no TDCA+blood Cellular senescence 0 0 -0.430817291 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Chemical carcinogenesis - receptor activation 0 0.50356808 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Chemokine signaling pathway -0.491124973 0 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Cysteine+blood -0.515821357 0 0 yes yes serum_bileacids serum_aminoacids 0.155 1.81E-07 no up no dn up up TDCA+blood d18:1-16:0-SM+blood 0 0 -0.457543065 yes serum_bileacids serum_phospholipids 0.155 0.14 no up no no no no TDCA+blood d18:1-20:1-SM+blood 0 0 -0.486694993 yes serum_bileacids serum_phospholipids 0.155 0.0992 no up no no no no TDCA+blood DHA+blood -0.462460527 0 0 yes serum_bileacids serum_ARA 0.155 0.872 no up no no no no TDCA+blood DPA+blood -0.472342162 0 0 yes serum_bileacids serum_ARA 0.155 0.519 no up no no no no TDCA+blood Endocrine resistance 0 0.650582922 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood GABAergic synapse 0 0 0.403791852 yes serum_bileacids kegg 0.155 NA no up no no up up TDCA+blood GCA+blood 0.498034414 0.532348644 0.490961129 yes yes serum_bileacids serum_bileacids 0.155 0.16 no up no no no no TDCA+blood GDCA+blood 0.743098967 0.867124595 0.705689964 yes serum_bileacids serum_bileacids 0.155 0.632 no up no no no no TDCA+blood GLCA+blood 0 0.509510171 0 yes serum_bileacids serum_bileacids 0.155 0.319 no up no no no no TDCA+blood Glutathione metabolism 0.659737003 0 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood GnRH signaling pathway 0 0.643823619 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood "Growth hormone synthesis, secretion and action" 0 0.530605292 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Hematopoietic cell lineage 0 0 0.440355681 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Insulin resistance 0 0 -0.404189285 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood iso-LCA+blood 0.484623378 0 0 yes serum_bileacids serum_bileacids 0.155 0.507 no up no no no no TDCA+blood iso-LCA+stool 0 0 0.523930692 yes serum_bileacids stool_bileacids 0.155 0.72 no up no no no no TDCA+blood LCA+blood 0 0 0.410585207 yes serum_bileacids serum_bileacids 0.155 0.884 no up no no no no TDCA+blood Lipid and atherosclerosis -0.458307867 0 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Longevity regulating pathway 0.462834364 0 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Longevity regulating pathway - multiple species 0 -0.525535815 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Malaria 0.478677105 0 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood nutriCA+stool 0 0 -0.539295228 yes serum_bileacids stool_bileacids 0.155 0.481 no up no no no no TDCA+blood "Parathyroid hormone synthesis, secretion and action" 0 0.571161111 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Prevotella 0.474016346 0.618432019 0 yes acetate-producing serum_bileacids Genus 0.155 0.287 no up no no no no TDCA+blood Protein processing in endoplasmic reticulum 0.471887359 0 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Purine metabolism 0.563548932 0 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Salmonella infection 0 -0.51539686 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Staphylococcus aureus infection 0 0 0.419689169 yes serum_bileacids kegg 0.155 NA no up no up no no TDCA+blood TCA+blood 0 0 0.688246223 yes serum_bileacids serum_bileacids 0.155 0.339 no up no no no no TDCA+blood Toxoplasmosis 0 0 0.447509474 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood UDCA+stool 0 -0.654299708 -0.553123311 yes serum_bileacids stool_bileacids 0.155 0.266 no up no no no no TDCA+blood Viral carcinogenesis 0 0 -0.422868632 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Viral myocarditis 0 -0.523845989 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+blood Yersinia infection -0.474150608 0 0 yes serum_bileacids kegg 0.155 NA no up no no no no TDCA+stool 12-ketoDCA+stool -0.60756467 -0.59900757 0 stool_bileacids stool_bileacids 0.963 0.505 no no no no no no TDCA+stool 4-hydroxybenzoic acid+stool 0 0.811516378 0.697260509 stool_bileacids stool_cometabolism 0.963 0.0536 no no no no dn no TDCA+stool Antigen processing and presentation 0 0.88396 0 stool_bileacids kegg 0.963 NA no no no no no no TDCA+stool Bacterial invasion of epithelial cells 0 0.618772 0 stool_bileacids kegg 0.963 NA no no no no no no TDCA+stool Butyric acid+stool -0.557109473 0 0 yes stool_bileacids stool_scfa 0.963 0.102 no no no dn no no TDCA+stool Caproic acid+stool 0 -0.733212166 0 stool_bileacids stool_scfa 0.963 0.882 no no no no no no TDCA+stool CDCA+stool 0 0 0.470987263 stool_bileacids stool_bileacids 0.963 0.663 no no no no no no TDCA+stool Chemical carcinogenesis - receptor activation 0 -0.604814737 0 stool_bileacids kegg 0.963 NA no no no no no no TDCA+stool Choline metabolism in cancer 0 -0.604814737 0 stool_bileacids kegg 0.963 NA no no no no no no TDCA+stool Clostridium 0 0.786464174 0 stool_bileacids Genus 0.963 0.925 no no no no no no TDCA+stool Cocaine addiction 0 -0.618772 0 stool_bileacids kegg 0.963 NA no no no no no no TDCA+stool Cortisol synthesis and secretion 0 -0.618772 0 stool_bileacids kegg 0.963 NA no no no no no up TDCA+stool Cushing syndrome 0 -0.623424421 0 stool_bileacids kegg 0.963 NA no no no no no up TDCA+stool DCA+stool 0 -0.654907955 -0.570168708 stool_bileacids stool_bileacids 0.963 0.195 no no no no no no TDCA+stool Epstein-Barr virus infection 0 0.88396 0 stool_bileacids kegg 0.963 NA no no no no no no TDCA+stool GCA+stool 0 0.701178625 0 stool_bileacids stool_bileacids 0.963 0.0809 no no no no no no TDCA+stool GUDCA+stool -0.497169988 0 0 yes stool_bileacids stool_bileacids 0.963 0.0085 no no no no dn no TDCA+stool HDCA+stool -0.504551975 0 -0.45404169 stool_bileacids stool_bileacids 0.963 0.176 no no no no no no TDCA+stool Herpes simplex virus 1 infection 0 0.874655158 0 stool_bileacids kegg 0.963 NA no no no no no no TDCA+stool Human cytomegalovirus infection 0 0.865350316 0 stool_bileacids kegg 0.963 NA no no no no no dn TDCA+stool Human immunodeficiency virus 1 infection 0 0.88396 0 stool_bileacids kegg 0.963 NA no no no no no no TDCA+stool Human T-cell leukemia virus 1 infection 0 0.88396 0 stool_bileacids kegg 0.963 NA no no no no no no TDCA+stool iso-LCA+stool 0 -0.754567861 -0.574654301 stool_bileacids stool_bileacids 0.963 0.72 no no no no no no TDCA+stool Isobutyric acid+stool 0 0 -0.473977659 stool_bileacids stool_scfa 0.963 0.408 no no no no no no TDCA+stool Isovaleric acid+stool 0 0 -0.471485663 stool_bileacids stool_scfa 0.963 0.343 no no no no no no TDCA+stool LCA+stool 0 -0.715415755 -0.518335189 stool_bileacids stool_bileacids 0.963 0.314 no no no no no no TDCA+stool Leukocyte transendothelial migration 0 0.749039789 0 stool_bileacids kegg 0.963 NA no no no no no no TDCA+stool nutriCA+stool 0 0 0.586117483 stool_bileacids stool_bileacids 0.963 0.481 no no no no no no TDCA+stool p53 signaling pathway 0 -0.735082526 0 stool_bileacids kegg 0.963 NA no no no no no no TDCA+stool Phenylacetic acid+stool 0 0 -0.572660704 stool_bileacids stool_cometabolism 0.963 0.785 no no no no no no TDCA+stool Proteasome 0 0.655991368 0 stool_bileacids kegg 0.963 NA no no no no no no TDCA+stool Regulation of actin cytoskeleton 0 0.66529621 0 stool_bileacids kegg 0.963 NA no no no no no no TDCA+stool TCA+stool 0.579329435 0.722018053 0 stool_bileacids stool_bileacids 0.963 0.458 no no no no no no TDCA+stool Tight junction 0 0.628076842 0 stool_bileacids kegg 0.963 NA no no no no no no Terpenoid backbone biosynthesis Amino sugar and nucleotide sugar metabolism 0 0.486166008 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Arachidonic acid metabolism 0 0 -0.418275418 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Ascorbate and aldarate metabolism 0 0.428853755 0.4998713 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Butanoate metabolism 0 0.551383399 0.478507079 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Citrate cycle (TCA cycle) 0.427826087 0.596837945 0.727413127 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Cysteine and methionine metabolism 0.520869565 0.468379447 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Ether lipid metabolism 0 0.508893281 0.630630631 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Folate biosynthesis 0 0 0.46975547 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Glycerolipid metabolism 0 0 0.476447876 kegg kegg NA NA no no no no no up Terpenoid backbone biosynthesis Glycerophospholipid metabolism 0 0 0.624453024 kegg kegg NA NA no no no no no up Terpenoid backbone biosynthesis "Glycine, serine and threonine metabolism" 0 0 -0.430888031 kegg kegg NA NA no no no no up no Terpenoid backbone biosynthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.490434783 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.462290862 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate 0 0 0.485456885 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Glycosaminoglycan degradation -0.474782609 0 0 kegg kegg NA NA no no no no no up Terpenoid backbone biosynthesis Glycosphingolipid biosynthesis - ganglio series 0 0.707509881 0.422393822 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.448695652 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Histidine metabolism 0 0.441699605 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Inositol phosphate metabolism 0 0 0.537194337 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Lysine degradation 0 0 0.594079794 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Mannose type O-glycan biosynthesis 0 0 0.538223938 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Mucin type O-glycan biosynthesis 0 0.486166008 0.556241956 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis N-Glycan biosynthesis 0.586956522 0.490118577 0.674646075 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis One carbon pool by folate 0.659130435 0.616600791 0.662805663 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Other types of O-glycan biosynthesis 0.426956522 0 0.668725869 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Pentose and glucuronate interconversions 0 0.588932806 0.547490347 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Pentose phosphate pathway -0.600869565 0 -0.491377091 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Primary bile acid biosynthesis 0.54173913 0.472332016 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Propanoate metabolism 0.425217391 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Pyrimidine metabolism 0 0.522727273 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Pyruvate metabolism 0.549565217 0.421936759 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Retinol metabolism 0 0.557312253 0.518146718 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Selenocompound metabolism 0.590434783 0.612648221 0.636293436 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Sphingolipid metabolism -0.49826087 0 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Steroid biosynthesis 0.789565217 0.685770751 0.638610039 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Steroid hormone biosynthesis 0 0.5 0.535907336 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Synthesis and degradation of ketone bodies 0.651304348 0.736166008 0.715572716 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Tryptophan metabolism 0 0.602766798 0.520720721 kegg kegg NA NA no no no no up no Terpenoid backbone biosynthesis Tyrosine metabolism 0 0.484189723 0 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis 0 0.707509881 0.668983269 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis "Valine, leucine and isoleucine degradation" 0 0.654150198 0.555469755 kegg kegg NA NA no no no no no no Terpenoid backbone biosynthesis Various types of N-glycan biosynthesis 0.546956522 0.511857708 0.654826255 kegg kegg NA NA no no no no no no TGF-beta signaling pathway 2-Oxocarboxylic acid metabolism 0 0.46541502 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway ABC transporters -0.424347826 -0.485177866 0 kegg kegg NA NA no no no no up up TGF-beta signaling pathway Adrenergic signaling in cardiomyocytes 0.52173913 0.567193676 0.424195624 kegg kegg NA NA no no no no no up TGF-beta signaling pathway "Alanine, aspartate and glutamate metabolism" -0.52173913 -0.783596838 -0.44993565 kegg kegg NA NA no no no no no no TGF-beta signaling pathway alpha-Linolenic acid metabolism -0.592173913 -0.727272727 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Amino sugar and nucleotide sugar metabolism -0.606956522 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Apoptosis -0.48 -0.596837945 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Arachidonic acid metabolism 0 0 -0.453796654 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Arginine and proline metabolism -0.459130435 -0.622529644 0 kegg kegg NA NA no no no no up no TGF-beta signaling pathway Arginine biosynthesis -0.565217391 -0.738142292 -0.497297297 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Autophagy - animal 0 -0.677865613 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Autophagy - other 0 0 0.521492921 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Basal transcription factors 0 0 0.629086229 kegg kegg NA NA no no no no no no TGF-beta signaling pathway beta-Alanine metabolism -0.550434783 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Biosynthesis of amino acids -0.729565217 -0.532608696 -0.611325611 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Biosynthesis of cofactors 0 0 -0.462033462 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Butanoate metabolism 0 0.631422925 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Calcium signaling pathway 0.686086957 0 0 kegg kegg NA NA no no no no up up TGF-beta signaling pathway cAMP signaling pathway 0.56173913 0 0 yes kegg kegg NA NA no no no no up up TGF-beta signaling pathway Carbon metabolism -0.605217391 0 -0.410810811 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Cardiac muscle contraction 0.690434783 0.612648221 0.478249678 kegg kegg NA NA no no no no no up TGF-beta signaling pathway Cell cycle 0 0.42687747 0.657142857 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Cellular senescence -0.431304348 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway cGMP-PKG signaling pathway 0 -0.494071146 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Chemokine signaling pathway 0 -0.453557312 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Citrate cycle (TCA cycle) 0 0.649209486 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Cysteine and methionine metabolism 0 0.719367589 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway DNA replication 0 0.52173913 0.404890605 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Drug metabolism - cytochrome P450 0 0.593873518 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Drug metabolism - other enzymes 0 0.750988142 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway EGFR tyrosine kinase inhibitor resistance 0 0.688735178 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Endocytosis -0.505217391 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway ErbB signaling pathway 0 -0.457509881 0.445302445 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Ether lipid metabolism 0.648695652 0.419960474 0.419305019 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Fanconi anemia pathway 0 0 0.443500644 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Fatty acid biosynthesis -0.477391304 -0.782608696 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Fatty acid degradation -0.613043478 -0.653162055 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Fatty acid elongation 0 0.429841897 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Fatty acid metabolism -0.613043478 -0.543478261 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Ferroptosis 0 0 -0.444015444 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Folate biosynthesis 0 0.578063241 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway FoxO signaling pathway 0 -0.632411067 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Fructose and mannose metabolism -0.72 -0.738142292 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Galactose metabolism -0.611304348 -0.654150198 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Glutathione metabolism 0 0.574110672 -0.416988417 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Glycerolipid metabolism 0 -0.697628458 0 kegg kegg NA NA no no no no no up TGF-beta signaling pathway Glycerophospholipid metabolism 0 -0.507905138 0.434749035 kegg kegg NA NA no no no no no up TGF-beta signaling pathway "Glycine, serine and threonine metabolism" 0 0 -0.463577864 kegg kegg NA NA no no no no up no TGF-beta signaling pathway Glycolysis / Gluconeogenesis -0.626956522 0.599802372 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.492173913 -0.802371542 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.457400257 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0.594782609 0 0.558558559 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.557391304 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Glyoxylate and dicarboxylate metabolism -0.576521739 -0.716403162 -0.496267696 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Hedgehog signaling pathway 0.58173913 0 0.537966538 kegg kegg NA NA no no no no no no TGF-beta signaling pathway HIF-1 signaling pathway 0 0.669960474 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Homologous recombination 0 0 0.459459459 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Inositol phosphate metabolism 0 -0.457509881 0.429343629 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Linoleic acid metabolism 0 0 0.471814672 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Lysine degradation 0 0 0.535649936 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Mannose type O-glycan biosynthesis 0.519130435 0 0.520720721 kegg kegg NA NA no no no no no no TGF-beta signaling pathway MAPK signaling pathway 0 -0.414031621 0.43011583 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Metabolism of xenobiotics by cytochrome P450 0 0.60770751 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Mismatch repair 0 0.458498024 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Mitophagy - animal 0.44 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway mRNA surveillance pathway 0.697391304 0.595849802 0.626254826 kegg kegg NA NA no no no no no no TGF-beta signaling pathway mTOR signaling pathway 0 0.700592885 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway N-Glycan biosynthesis 0 0.696640316 0.535392535 kegg kegg NA NA no no no no no no TGF-beta signaling pathway NF-kappa B signaling pathway 0 -0.73715415 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Nicotinate and nicotinamide metabolism -0.473043478 -0.770750988 -0.491119691 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Nitrogen metabolism -0.626956522 -0.654150198 -0.472844273 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Non-homologous end-joining -0.480869565 0.463438735 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Notch signaling pathway 0.469565217 -0.445652174 0.543629344 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Nucleotide excision repair 0 0.43972332 0.431402831 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Oocyte meiosis 0.633913043 0.83201581 0.719433719 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Other glycan degradation -0.417391304 -0.5 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Other types of O-glycan biosynthesis 0 0 0.52972973 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Oxidative phosphorylation 0.704347826 0.679841897 0.416988417 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Pantothenate and CoA biosynthesis -0.409565217 -0.62055336 0 kegg kegg NA NA no no no no no dn TGF-beta signaling pathway Pentose and glucuronate interconversions 0 0.730237154 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Pentose phosphate pathway -0.543478261 -0.423913043 -0.570656371 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Peroxisome -0.466956522 -0.604743083 -0.599227799 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Phagosome -0.569565217 0 -0.501415701 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Phenylalanine metabolism 0 0.438735178 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Phosphatidylinositol signaling system 0.730434783 0 0.638867439 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Phospholipase D signaling pathway 0 -0.777667984 0 kegg kegg NA NA no no no no up up TGF-beta signaling pathway Platinum drug resistance 0 0 0.431145431 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Porphyrin and chlorophyll metabolism 0 0 -0.501158301 kegg kegg NA NA no no no no no no TGF-beta signaling pathway PPAR signaling pathway -0.420869565 -0.603754941 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Primary bile acid biosynthesis 0 0.505928854 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Propanoate metabolism 0 0.67687747 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Proteasome 0 0.677865613 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Protein export 0.614782609 0.887351779 0.497554698 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Protein processing in endoplasmic reticulum 0 0.666996047 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Purine metabolism 0 0 -0.453281853 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Pyrimidine metabolism -0.44 0.444664032 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Pyruvate metabolism 0 0.712450593 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Ras signaling pathway 0.584347826 0.765810277 0.819047619 yes kegg kegg NA NA no no no no up up TGF-beta signaling pathway Retinol metabolism -0.439130435 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Ribosome 0.669565217 0.726284585 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Ribosome biogenesis in eukaryotes 0 0 0.541312741 kegg kegg NA NA no no no no no no TGF-beta signaling pathway RNA degradation 0.768695652 0.741106719 0.637065637 kegg kegg NA NA no no no no no no TGF-beta signaling pathway RNA polymerase 0 0.509881423 0.488545689 kegg kegg NA NA no no no no no no TGF-beta signaling pathway RNA transport 0 0.654150198 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway SNARE interactions in vesicular transport 0 -0.544466403 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Sphingolipid signaling pathway 0 0 0.598198198 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Spliceosome 0 0 0.5001287 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Starch and sucrose metabolism -0.60173913 -0.744071146 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Steroid biosynthesis 0.440869565 0.482213439 0.408751609 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Sulfur metabolism 0 0 -0.625225225 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Taurine and hypotaurine metabolism 0 -0.612648221 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Terpenoid backbone biosynthesis 0 0 0.519176319 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Thiamine metabolism 0 0.621541502 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Tryptophan metabolism 0 0.500988142 0 kegg kegg NA NA no no no no up no TGF-beta signaling pathway Tyrosine metabolism 0 0.466403162 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Ubiquitin mediated proteolysis 0.503478261 0 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway "Valine, leucine and isoleucine degradation" 0 0.503952569 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Various types of N-glycan biosynthesis 0 0.619565217 0.496782497 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Vascular smooth muscle contraction 0.64 0.630434783 0 kegg kegg NA NA no no no no no no TGF-beta signaling pathway Wnt signaling pathway 0.804347826 0.672924901 0.754954955 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation 2-Oxocarboxylic acid metabolism 0 0 0.517374517 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Adrenergic signaling in cardiomyocytes 0 -0.532608696 0 kegg kegg NA NA no no no no no up Th1 and Th2 cell differentiation "Alanine, aspartate and glutamate metabolism" 0 0 -0.425997426 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation AMPK signaling pathway 0 -0.518774704 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Anaerostipes -0.411403111 0 0 butyrate-producing kegg Genus NA 0.568 no no no no no no Th1 and Th2 cell differentiation Apoptosis 0 0.545454545 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Arginine biosynthesis 0 0 -0.45045045 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Biosynthesis of cofactors 0 -0.592885375 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation C-type lectin receptor signaling pathway 0 0.590909091 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Cell adhesion molecules 0 0.579051383 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Cellular senescence 0 0.518774704 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Cysteine and methionine metabolism -0.528695652 0 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Drug metabolism - other enzymes 0 0 0.484684685 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Endocytosis 0 0.467391304 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Ferroptosis 0 0 -0.482110682 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation FoxO signaling pathway -0.456521739 0 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Galactose metabolism 0 0.429841897 0.454826255 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Glutathione metabolism 0 -0.639328063 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation "Glycine, serine and threonine metabolism" 0 -0.596837945 0 kegg kegg NA NA no no no no up no Th1 and Th2 cell differentiation Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.545688546 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Glycosaminoglycan degradation 0 0.42687747 0.423680824 kegg kegg NA NA no no no no no up Th1 and Th2 cell differentiation Hedgehog signaling pathway 0 0 0.47027027 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Hematopoietic cell lineage 0 0 0.485456885 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Longevity regulating pathway 0 0 -0.423938224 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Longevity regulating pathway - multiple species -0.643478261 0 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Lysine degradation 0 0 0.425225225 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Mismatch repair 0 -0.414031621 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Mucin type O-glycan biosynthesis -0.533913043 0 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Natural killer cell mediated cytotoxicity 0 0.488142292 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Necroptosis 0 0 -0.516859717 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation NF-kappa B signaling pathway 0 0.416996047 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Nitrogen metabolism 0 0 -0.477220077 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation NOD-like receptor signaling pathway 0 0.537549407 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Osteoclast differentiation 0 0.481225296 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Other glycan degradation 0 0.535573123 0.505534106 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Pentose and glucuronate interconversions 0 0 0.534877735 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Peroxisome 0 0 -0.46975547 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Phagosome 0 0.469367589 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Porphyrin and chlorophyll metabolism 0 -0.490118577 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Propanoate metabolism -0.52173913 0 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Purine metabolism 0 -0.526679842 -0.442985843 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Pyrimidine metabolism 0 -0.443675889 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Pyruvate metabolism -0.413043478 0 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation RNA degradation 0 0 0.454826255 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation SNARE interactions in vesicular transport 0 0.436758893 0.425997426 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Sulfur metabolism 0 -0.536561265 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Toll-like receptor signaling pathway 0 0.484189723 0 yes kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Ubiquitin mediated proteolysis 0 -0.42687747 0 kegg kegg NA NA no no no no no no Th1 and Th2 cell differentiation Vascular smooth muscle contraction 0 -0.609683794 0 kegg kegg NA NA no no no no no no Th17 cell differentiation 2-Oxocarboxylic acid metabolism 0 0 0.455855856 kegg kegg NA NA no no no no no no Th17 cell differentiation Adrenergic signaling in cardiomyocytes 0 -0.505928854 0 kegg kegg NA NA no no no no no up Th17 cell differentiation Aminoacyl-tRNA biosynthesis 0 0 0.401029601 kegg kegg NA NA no no no no no no Th17 cell differentiation AMPK signaling pathway 0 -0.435770751 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Anaerostipes -0.459597298 0 0 butyrate-producing kegg Genus NA 0.568 no no no no no no Th17 cell differentiation Apoptosis 0 0.537549407 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Arachidonic acid metabolism 0 -0.484189723 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Arginine biosynthesis 0 0 -0.424710425 kegg kegg NA NA no no no no no no Th17 cell differentiation Biosynthesis of cofactors 0 -0.553359684 0 kegg kegg NA NA no no no no no no Th17 cell differentiation C-type lectin receptor signaling pathway 0 0.64229249 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Cell adhesion molecules 0 0.558300395 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Cellular senescence 0 0.513833992 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Cysteine and methionine metabolism -0.459130435 0 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Cytosolic DNA-sensing pathway 0 0.506916996 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Drug metabolism - other enzymes 0 0 0.41981982 kegg kegg NA NA no no no no no no Th17 cell differentiation Endocytosis 0 0.460474308 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Ferroptosis 0 0 -0.484169884 kegg kegg NA NA no no no no no no Th17 cell differentiation Galactose metabolism 0 0 0.429343629 kegg kegg NA NA no no no no no no Th17 cell differentiation Glutathione metabolism 0 -0.637351779 0 kegg kegg NA NA no no no no no no Th17 cell differentiation "Glycine, serine and threonine metabolism" 0 -0.551383399 0 kegg kegg NA NA no no no no up no Th17 cell differentiation Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 0.48957529 kegg kegg NA NA no no no no no no Th17 cell differentiation Hedgehog signaling pathway 0 0 0.489317889 kegg kegg NA NA no no no no no no Th17 cell differentiation Hematopoietic cell lineage 0 0 0.571685972 kegg kegg NA NA no no no no no no Th17 cell differentiation Longevity regulating pathway - multiple species -0.546086957 0 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Lysine degradation 0 0 0.441698842 kegg kegg NA NA no no no no no no Th17 cell differentiation Mismatch repair 0 -0.420948617 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Mucin type O-glycan biosynthesis -0.473043478 0 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Natural killer cell mediated cytotoxicity 0 0.479249012 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Necroptosis 0 0 -0.500900901 kegg kegg NA NA no no no no no no Th17 cell differentiation NF-kappa B signaling pathway 0.434782609 0.475296443 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Nitrogen metabolism 0 0 -0.482110682 kegg kegg NA NA no no no no no no Th17 cell differentiation NOD-like receptor signaling pathway 0 0.605731225 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Osteoclast differentiation 0 0.501976285 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Other glycan degradation 0 0.541501976 0.492149292 kegg kegg NA NA no no no no no no Th17 cell differentiation Oxidative phosphorylation 0 -0.427865613 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Pentose and glucuronate interconversions 0 0 0.503732304 kegg kegg NA NA no no no no no no Th17 cell differentiation Phagosome 0 0.429841897 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Platelet activation 0 -0.42687747 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Porphyrin and chlorophyll metabolism 0 -0.437747036 0 kegg kegg NA NA no no no no no no Th17 cell differentiation PPAR signaling pathway 0 0.467391304 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Propanoate metabolism -0.45826087 0 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Purine metabolism 0 -0.471343874 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Pyrimidine metabolism 0 -0.484189723 0 kegg kegg NA NA no no no no no no Th17 cell differentiation RIG-I-like receptor signaling pathway 0 0.468379447 0 kegg kegg NA NA no no no no no no Th17 cell differentiation RNA degradation 0 0 0.486743887 kegg kegg NA NA no no no no no no Th17 cell differentiation Sarcina 0 0.422326513 0 kegg Genus NA 0.0703 no no no no no no Th17 cell differentiation SNARE interactions in vesicular transport 0 0.490118577 0.4002574 kegg kegg NA NA no no no no no no Th17 cell differentiation Sphingolipid signaling pathway 0 0.422924901 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Sulfur metabolism 0 -0.51284585 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Th1 and Th2 cell differentiation 0.954782609 0.971343874 0.960875161 kegg kegg NA NA no no no no no no Th17 cell differentiation Toll-like receptor signaling pathway 0 0.514822134 0 yes kegg kegg NA NA no no no no no no Th17 cell differentiation Tyrosine metabolism 0 -0.434782609 0 kegg kegg NA NA no no no no no no Th17 cell differentiation Vascular smooth muscle contraction 0 -0.647233202 0 kegg kegg NA NA no no no no no no Thermogenesis 2-Oxocarboxylic acid metabolism -0.442608696 0 0 kegg kegg NA NA no no no no no no Thermogenesis ABC transporters -0.437391304 -0.414031621 0 kegg kegg NA NA no no no no up up Thermogenesis Adherens junction 0 0.690711462 0.564993565 kegg kegg NA NA no no no no no no Thermogenesis Adrenergic signaling in cardiomyocytes 0.69826087 0.818181818 0 kegg kegg NA NA no no no no no up Thermogenesis "Alanine, aspartate and glutamate metabolism" -0.635652174 -0.803359684 -0.54980695 kegg kegg NA NA no no no no no no Thermogenesis alpha-Linolenic acid metabolism -0.605217391 -0.770750988 0 kegg kegg NA NA no no no no no no Thermogenesis Amino sugar and nucleotide sugar metabolism -0.588695652 0 0 kegg kegg NA NA no no no no no no Thermogenesis Aminoacyl-tRNA biosynthesis -0.546956522 0 0 kegg kegg NA NA no no no no no no Thermogenesis AMPK signaling pathway 0 0.440711462 0 kegg kegg NA NA no no no no no no Thermogenesis Apelin signaling pathway 0 0.808300395 0.43037323 kegg kegg NA NA no no no no no no Thermogenesis Apoptosis -0.433043478 -0.62944664 0 kegg kegg NA NA no no no no no no Thermogenesis Apoptosis - multiple species 0 -0.441699605 0 kegg kegg NA NA no no no no no no Thermogenesis Arginine and proline metabolism -0.432173913 -0.831027668 -0.585328185 kegg kegg NA NA no no no no up no Thermogenesis Arginine biosynthesis -0.649565217 -0.745059289 -0.514285714 kegg kegg NA NA no no no no no no Thermogenesis Autophagy - animal 0 -0.763833992 -0.616216216 kegg kegg NA NA no no no no no no Thermogenesis Axon guidance 0.430434783 0 0 kegg kegg NA NA no no no no up up Thermogenesis B cell receptor signaling pathway 0 -0.677865613 0 kegg kegg NA NA no no no no no no Thermogenesis Bacteroides -0.406086957 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Thermogenesis beta-Alanine metabolism -0.655652174 0 0 kegg kegg NA NA no no no no no no Thermogenesis Biosynthesis of amino acids -0.815652174 -0.641304348 0 kegg kegg NA NA no no no no no no Thermogenesis Biosynthesis of unsaturated fatty acids -0.419130435 0 0 kegg kegg NA NA no no no no no no Thermogenesis Butanoate metabolism -0.491304348 0.443675889 0 kegg kegg NA NA no no no no no no Thermogenesis C-type lectin receptor signaling pathway 0 -0.67687747 -0.435521236 kegg kegg NA NA no no no no no no Thermogenesis Calcium signaling pathway 0.713043478 0.719367589 0 kegg kegg NA NA no no no no up up Thermogenesis cAMP signaling pathway 0.713913043 0 0 yes kegg kegg NA NA no no no no up up Thermogenesis Carbon metabolism -0.711304348 0 0 kegg kegg NA NA no no no no no no Thermogenesis Cardiac muscle contraction 0.948695652 0.973320158 0.895752896 kegg kegg NA NA no no no no no up Thermogenesis Cell adhesion molecules -0.534782609 -0.431818182 0 kegg kegg NA NA no no no no no no Thermogenesis Cell cycle 0 0.441699605 0 kegg kegg NA NA no no no no no no Thermogenesis Cellular senescence -0.409565217 -0.45256917 0 kegg kegg NA NA no no no no no no Thermogenesis cGMP-PKG signaling pathway 0 -0.658102767 0 kegg kegg NA NA no no no no no no Thermogenesis Chemokine signaling pathway 0 -0.479249012 0 kegg kegg NA NA no no no no no no Thermogenesis Circadian entrainment 0.411304348 0.595849802 0 kegg kegg NA NA no no no no up up Thermogenesis Circadian rhythm 0.576521739 0 0 kegg kegg NA NA no no no no no no Thermogenesis Citrate cycle (TCA cycle) 0 0.481225296 0 kegg kegg NA NA no no no no no no Thermogenesis Complement and coagulation cascades -0.644347826 -0.653162055 0 kegg kegg NA NA no no no no no no Thermogenesis Cysteine and methionine metabolism 0 0.552371542 0.459459459 kegg kegg NA NA no no no no no no Thermogenesis DNA replication 0 0.508893281 0 kegg kegg NA NA no no no no no no Thermogenesis Drug metabolism - cytochrome P450 0 0.557312253 0 kegg kegg NA NA no no no no no no Thermogenesis Drug metabolism - other enzymes -0.526956522 0.605731225 0 kegg kegg NA NA no no no no no no Thermogenesis EGFR tyrosine kinase inhibitor resistance 0 0.735177866 0 kegg kegg NA NA no no no no no no Thermogenesis Endocrine resistance 0.434782609 0 0 kegg kegg NA NA no no no no no no Thermogenesis Endocytosis -0.496521739 -0.471343874 0 kegg kegg NA NA no no no no no no Thermogenesis ErbB signaling pathway 0 -0.434782609 0 kegg kegg NA NA no no no no no no Thermogenesis Ether lipid metabolism 0.749565217 0.443675889 0 kegg kegg NA NA no no no no no no Thermogenesis Fatty acid biosynthesis -0.547826087 -0.815217391 -0.592020592 kegg kegg NA NA no no no no no no Thermogenesis Fatty acid degradation -0.710434783 -0.813241107 0 kegg kegg NA NA no no no no no no Thermogenesis Fatty acid elongation -0.47826087 0 0 kegg kegg NA NA no no no no no no Thermogenesis Fatty acid metabolism -0.793043478 -0.790513834 0 kegg kegg NA NA no no no no no no Thermogenesis Fc epsilon RI signaling pathway 0 -0.740118577 0 kegg kegg NA NA no no no no no no Thermogenesis Fc gamma R-mediated phagocytosis -0.520869565 -0.637351779 0 kegg kegg NA NA no no no no no no Thermogenesis Focal adhesion 0 0.566205534 0.427284427 kegg kegg NA NA no no no no up up Thermogenesis Folate biosynthesis 0 0.464426877 0 kegg kegg NA NA no no no no no no Thermogenesis FoxO signaling pathway 0 -0.747035573 0 kegg kegg NA NA no no no no no no Thermogenesis Fructose and mannose metabolism -0.710434783 -0.617588933 -0.503474903 kegg kegg NA NA no no no no no no Thermogenesis Galactose metabolism -0.693913043 -0.753952569 0 kegg kegg NA NA no no no no no no Thermogenesis Glutathione metabolism 0 0.686758893 0 kegg kegg NA NA no no no no no no Thermogenesis Glycerolipid metabolism 0 -0.623517787 0 kegg kegg NA NA no no no no no up Thermogenesis Glycolysis / Gluconeogenesis -0.607826087 0.511857708 0 kegg kegg NA NA no no no no no no Thermogenesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.425217391 -0.780632411 0 kegg kegg NA NA no no no no no no Thermogenesis Glycosaminoglycan biosynthesis - keratan sulfate 0.575652174 0 0 kegg kegg NA NA no no no no no no Thermogenesis Glycosaminoglycan degradation 0 -0.469367589 0 kegg kegg NA NA no no no no no up Thermogenesis Glyoxylate and dicarboxylate metabolism -0.751304348 -0.75 -0.556756757 kegg kegg NA NA no no no no no no Thermogenesis Hedgehog signaling pathway 0.51826087 0 0 kegg kegg NA NA no no no no no no Thermogenesis HIF-1 signaling pathway 0 0.701581028 0 kegg kegg NA NA no no no no no no Thermogenesis Hippo signaling pathway 0 0.678853755 0.548519949 kegg kegg NA NA no no no no no no Thermogenesis Hippo signaling pathway - multiple species 0 -0.808300395 0 kegg kegg NA NA no no no no no no Thermogenesis IL-17 signaling pathway 0 -0.574110672 -0.465122265 kegg kegg NA NA no no no no no no Thermogenesis Inositol phosphate metabolism 0 -0.457509881 0 kegg kegg NA NA no no no no no no Thermogenesis JAK-STAT signaling pathway 0 -0.778656126 0 kegg kegg NA NA no no no no no no Thermogenesis Mannose type O-glycan biosynthesis 0.496521739 0 0 kegg kegg NA NA no no no no no no Thermogenesis MAPK signaling pathway 0 -0.639328063 0 kegg kegg NA NA no no no no no no Thermogenesis Metabolism of xenobiotics by cytochrome P450 0 0.513833992 0 kegg kegg NA NA no no no no no no Thermogenesis Mitophagy - animal 0.586086957 0.779644269 0 kegg kegg NA NA no no no no no no Thermogenesis mRNA surveillance pathway 0.708695652 0.646245059 0 kegg kegg NA NA no no no no no no Thermogenesis mTOR signaling pathway 0 0.713438735 0 kegg kegg NA NA no no no no no no Thermogenesis N-Glycan biosynthesis 0 0.621541502 0 kegg kegg NA NA no no no no no no Thermogenesis Natural killer cell mediated cytotoxicity -0.493913043 -0.422924901 0 kegg kegg NA NA no no no no no no Thermogenesis Neuroactive ligand-receptor interaction 0 -0.509881423 0 kegg kegg NA NA no no no up up up Thermogenesis Neutrophil extracellular trap formation -0.503478261 -0.53458498 0 kegg kegg NA NA no no no no no no Thermogenesis NF-kappa B signaling pathway 0 -0.786561265 -0.469498069 kegg kegg NA NA no no no no no no Thermogenesis Nicotinate and nicotinamide metabolism -0.54 -0.778656126 -0.507335907 kegg kegg NA NA no no no no no no Thermogenesis Nitrogen metabolism -0.549565217 -0.661067194 -0.521750322 kegg kegg NA NA no no no no no no Thermogenesis NOD-like receptor signaling pathway -0.453913043 -0.808300395 -0.428314028 kegg kegg NA NA no no no no no no Thermogenesis Non-homologous end-joining -0.576521739 0 0 kegg kegg NA NA no no no no no no Thermogenesis Oocyte meiosis 0 0.524703557 0.402574003 kegg kegg NA NA no no no no no no Thermogenesis Oscillospira 0 -0.462450593 0 LPS-producing kegg Genus NA 0.62 no no no no no no Thermogenesis Osteoclast differentiation 0 -0.752964427 -0.485199485 kegg kegg NA NA no no no no no no Thermogenesis Other glycan degradation -0.427826087 -0.537549407 0 kegg kegg NA NA no no no no no no Thermogenesis Oxidative phosphorylation 0.966956522 0.984189723 0.94980695 kegg kegg NA NA no no no no no no Thermogenesis Pantothenate and CoA biosynthesis -0.444347826 -0.820158103 -0.473873874 kegg kegg NA NA no no no no no dn Thermogenesis Pentose and glucuronate interconversions 0 0.58201581 0.456113256 kegg kegg NA NA no no no no no no Thermogenesis Pentose phosphate pathway -0.52 -0.563241107 -0.441441441 kegg kegg NA NA no no no no no no Thermogenesis Peroxisome -0.663478261 -0.751976285 0 kegg kegg NA NA no no no no no no Thermogenesis Phagosome -0.573043478 -0.437747036 0 kegg kegg NA NA no no no no no no Thermogenesis Phosphatidylinositol signaling system 0.528695652 0 0 kegg kegg NA NA no no no no no no Thermogenesis Phospholipase D signaling pathway 0 -0.598814229 0 kegg kegg NA NA no no no no up up Thermogenesis Platelet activation 0 0.557312253 0 kegg kegg NA NA no no no no no no Thermogenesis PPAR signaling pathway 0 -0.621541502 0 kegg kegg NA NA no no no no no no Thermogenesis Propanoate metabolism 0 0.522727273 0.424453024 kegg kegg NA NA no no no no no no Thermogenesis Proteasome 0 0.5256917 0 kegg kegg NA NA no no no no no no Thermogenesis Protein export 0.515652174 0.786561265 0.507078507 kegg kegg NA NA no no no no no no Thermogenesis Protein processing in endoplasmic reticulum 0 0.646245059 0 kegg kegg NA NA no no no no no no Thermogenesis Purine metabolism 0 0.421936759 0 kegg kegg NA NA no no no no no no Thermogenesis Pyrimidine metabolism -0.706956522 0 0 kegg kegg NA NA no no no no no no Thermogenesis Pyruvate metabolism 0 0.635375494 0 kegg kegg NA NA no no no no no no Thermogenesis Rap1 signaling pathway 0 0.437747036 0 kegg kegg NA NA no no no no no no Thermogenesis Ras signaling pathway 0 0.575098814 0 yes kegg kegg NA NA no no no no up up Thermogenesis Renin-angiotensin system 0 -0.598814229 0 kegg kegg NA NA no no no no no no Thermogenesis Retinol metabolism -0.50173913 0 0 kegg kegg NA NA no no no no no no Thermogenesis Ribosome 0.756521739 0.898221344 0.545173745 kegg kegg NA NA no no no no no no Thermogenesis RIG-I-like receptor signaling pathway 0 -0.743083004 -0.421106821 kegg kegg NA NA no no no no no no Thermogenesis RNA degradation 0.680869565 0.700592885 0 kegg kegg NA NA no no no no no no Thermogenesis RNA polymerase 0 0.589920949 0 kegg kegg NA NA no no no no no no Thermogenesis RNA transport 0 0.628458498 0 kegg kegg NA NA no no no no no no Thermogenesis Ruminococcus 0.406956522 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Thermogenesis Signaling pathways regulating pluripotency of stem cells 0.532173913 0 0 kegg kegg NA NA no no no no no no Thermogenesis SNARE interactions in vesicular transport 0 -0.722332016 0 kegg kegg NA NA no no no no no no Thermogenesis Starch and sucrose metabolism -0.512173913 -0.830039526 0 kegg kegg NA NA no no no no no no Thermogenesis T cell receptor signaling pathway 0 -0.495059289 0 kegg kegg NA NA no no no no no no Thermogenesis Taurine and hypotaurine metabolism 0 -0.437747036 0 kegg kegg NA NA no no no no no no Thermogenesis TGF-beta signaling pathway 0.74173913 0.706521739 0 kegg kegg NA NA no no no no no no Thermogenesis Th1 and Th2 cell differentiation 0 -0.415019763 0 kegg kegg NA NA no no no no no no Thermogenesis Th17 cell differentiation 0 -0.43083004 0 kegg kegg NA NA no no no no no no Thermogenesis Thiamine metabolism 0 0.486166008 0 kegg kegg NA NA no no no no no no Thermogenesis Tight junction 0 0.550395257 0 kegg kegg NA NA no no no no no no Thermogenesis TNF signaling pathway 0 -0.614624506 0 kegg kegg NA NA no no no no no no Thermogenesis Toll-like receptor signaling pathway 0 -0.703557312 0 yes kegg kegg NA NA no no no no no no Thermogenesis Tryptophan metabolism -0.469565217 0 0 kegg kegg NA NA no no no no up no Thermogenesis Ubiquitin mediated proteolysis 0.606956522 0.799407115 0 kegg kegg NA NA no no no no no no Thermogenesis Vascular smooth muscle contraction 0.74 0.858695652 0 kegg kegg NA NA no no no no no no Thermogenesis VEGF signaling pathway 0 -0.424901186 0 kegg kegg NA NA no no no no no no Thermogenesis Wnt signaling pathway 0.793913043 0.691699605 0 kegg kegg NA NA no no no no no no Thiamine metabolism "Alanine, aspartate and glutamate metabolism" 0 -0.475296443 0 kegg kegg NA NA no no no no no no Thiamine metabolism alpha-Linolenic acid metabolism 0.425217391 -0.463438735 0 kegg kegg NA NA no no no no no no Thiamine metabolism Amino sugar and nucleotide sugar metabolism 0.535652174 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Arginine and proline metabolism 0 -0.432806324 0 kegg kegg NA NA no no no no up no Thiamine metabolism Arginine biosynthesis 0 -0.455533597 0 kegg kegg NA NA no no no no no no Thiamine metabolism Butanoate metabolism 0.513913043 0.743083004 0 kegg kegg NA NA no no no no no no Thiamine metabolism Citrate cycle (TCA cycle) 0 0.683794466 0 kegg kegg NA NA no no no no no no Thiamine metabolism Cysteine and methionine metabolism 0.643478261 0.793478261 0 kegg kegg NA NA no no no no no no Thiamine metabolism Ether lipid metabolism 0 0.43972332 0 kegg kegg NA NA no no no no no no Thiamine metabolism Fatty acid biosynthesis 0 -0.503952569 0 kegg kegg NA NA no no no no no no Thiamine metabolism Fatty acid elongation 0 0.544466403 0 kegg kegg NA NA no no no no no no Thiamine metabolism Fructose and mannose metabolism 0.405217391 -0.421936759 0 kegg kegg NA NA no no no no no no Thiamine metabolism Galactose metabolism 0 -0.542490119 0 kegg kegg NA NA no no no no no no Thiamine metabolism Glutathione metabolism 0 0.626482213 0 kegg kegg NA NA no no no no no no Thiamine metabolism Glycerolipid metabolism 0 -0.438735178 0 kegg kegg NA NA no no no no no up Thiamine metabolism "Glycine, serine and threonine metabolism" 0 0.588932806 0 kegg kegg NA NA no no no no up no Thiamine metabolism Glycolysis / Gluconeogenesis 0 0.673913043 0 kegg kegg NA NA no no no no no no Thiamine metabolism Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.696640316 0 kegg kegg NA NA no no no no no no Thiamine metabolism Glycosaminoglycan biosynthesis - keratan sulfate -0.48 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Glycosaminoglycan degradation 0 -0.517786561 0 kegg kegg NA NA no no no no no up Thiamine metabolism Glycosphingolipid biosynthesis - lacto and neolacto series 0 -0.504940711 0 kegg kegg NA NA no no no no no no Thiamine metabolism Glyoxylate and dicarboxylate metabolism 0 -0.440711462 0 kegg kegg NA NA no no no no no no Thiamine metabolism Histidine metabolism 0.408695652 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Linoleic acid metabolism 0.406956522 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism Mucin type O-glycan biosynthesis 0.445217391 0 0 kegg kegg NA NA no no no no no no Thiamine metabolism N-Glycan biosynthesis 0 0.565217391 0 kegg kegg NA NA no no no no no no Thiamine metabolism One carbon pool by folate 0.445217391 0.507905138 0 kegg kegg NA NA no no no no no no Thiamine metabolism Other glycan degradation 0 -0.416996047 0 kegg kegg NA NA no no no no no no Thiamine metabolism Pentose and glucuronate interconversions 0.460869565 0.646245059 0 kegg kegg NA NA no no no no no no Thiamine metabolism Pentose phosphate pathway 0 -0.445652174 0 kegg kegg NA NA no no no no no no Thiamine metabolism Phenylalanine metabolism 0 0.491106719 0 kegg kegg NA NA no no no no no no Thiamine metabolism Primary bile acid biosynthesis 0.482608696 0.540513834 0 kegg kegg NA NA no no no no no no Thiamine metabolism Propanoate metabolism 0.633043478 0.809288538 0 kegg kegg NA NA no no no no no no Thiamine metabolism Purine metabolism 0 0.480237154 0.435006435 kegg kegg NA NA no no no no no no Thiamine metabolism Pyrimidine metabolism 0.453913043 0.441699605 0 kegg kegg NA NA no no no no no no Thiamine metabolism Pyruvate metabolism 0.58173913 0.833992095 0 kegg kegg NA NA no no no no no no Thiamine metabolism Starch and sucrose metabolism 0.422608696 -0.568181818 0 kegg kegg NA NA no no no no no no Thiamine metabolism Steroid biosynthesis 0 0.472332016 0 kegg kegg NA NA no no no no no no Thiamine metabolism Steroid hormone biosynthesis 0 0.51284585 0 kegg kegg NA NA no no no no no no Thiamine metabolism Synthesis and degradation of ketone bodies 0.570434783 0.615612648 0 kegg kegg NA NA no no no no no no Thiamine metabolism Taurine and hypotaurine metabolism 0 -0.461462451 0 kegg kegg NA NA no no no no no no Thiamine metabolism Tryptophan metabolism 0.448695652 0.562252964 0 kegg kegg NA NA no no no no up no Thiamine metabolism Tyrosine metabolism 0 0.647233202 0 kegg kegg NA NA no no no no no no Thiamine metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.577391304 0.539525692 0 kegg kegg NA NA no no no no no no Thiamine metabolism "Valine, leucine and isoleucine degradation" 0.52 0.617588933 0 kegg kegg NA NA no no no no no no Thiamine metabolism Various types of N-glycan biosynthesis 0 0.505928854 0 kegg kegg NA NA no no no no no no Thyroid cancer African trypanosomiasis 0 0 -0.653539254 kegg kegg NA NA no no no no no no Thyroid cancer alpha-Linolenic acid metabolism 0 0 -0.446846847 kegg kegg NA NA no no no no no no Thyroid cancer Amphetamine addiction 0 0 0.473359073 kegg kegg NA NA no no no no no no Thyroid cancer AMPK signaling pathway 0 0 0.418790219 kegg kegg NA NA no no no no no no Thyroid cancer Antigen processing and presentation 0 0.455533597 0 kegg kegg NA NA no no no no no no Thyroid cancer Ascorbate and aldarate metabolism 0 0 -0.405662806 kegg kegg NA NA no no no no no no Thyroid cancer Autophagy - other 0 -0.419960474 0 kegg kegg NA NA no no no no no no Thyroid cancer Basal transcription factors -0.499130435 0 0 kegg kegg NA NA no no no no no no Thyroid cancer Bile secretion 0 0 0.440926641 kegg kegg NA NA no no no no no no Thyroid cancer Chemical carcinogenesis - receptor activation 0 -0.494071146 0 kegg kegg NA NA no no no no no no Thyroid cancer Drug metabolism - other enzymes 0 0.467391304 -0.489060489 kegg kegg NA NA no no no no no no Thyroid cancer ECM-receptor interaction 0 0 0.445302445 kegg kegg NA NA no no no no up up Thyroid cancer Endocrine resistance 0 0 0.436036036 kegg kegg NA NA no no no no no no Thyroid cancer Epstein-Barr virus infection 0 0.43972332 0 kegg kegg NA NA no no no no no no Thyroid cancer Estrogen signaling pathway 0 0 0.554440154 kegg kegg NA NA no no no no no no Thyroid cancer Fat digestion and absorption 0 0 -0.55032175 yes kegg kegg NA NA no no no no up up Thyroid cancer Focal adhesion 0 0.434782609 0 kegg kegg NA NA no no no no up up Thyroid cancer Fructose and mannose metabolism 0 0 -0.642471042 kegg kegg NA NA no no no no no no Thyroid cancer Galactose metabolism 0 0 -0.475418275 kegg kegg NA NA no no no no no no Thyroid cancer Gap junction 0 0 0.438867439 kegg kegg NA NA no no no no no no Thyroid cancer Glucagon signaling pathway 0 0 0.431660232 kegg kegg NA NA no no no no no no Thyroid cancer Glutamatergic synapse 0 0 0.442985843 kegg kegg NA NA no no no no up up Thyroid cancer Glycerolipid metabolism 0 -0.442687747 0 kegg kegg NA NA no no no no no up Thyroid cancer Glycerophospholipid metabolism 0 -0.592885375 0 kegg kegg NA NA no no no no no up Thyroid cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0 -0.507335907 kegg kegg NA NA no no no no no no Thyroid cancer Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.442728443 kegg kegg NA NA no no no no no no Thyroid cancer Glycosaminoglycan degradation 0 0 -0.488545689 kegg kegg NA NA no no no no no up Thyroid cancer GnRH secretion 0 -0.461462451 0 kegg kegg NA NA no no no no up up Thyroid cancer GnRH signaling pathway 0 0 0.441184041 kegg kegg NA NA no no no no no no Thyroid cancer "Growth hormone synthesis, secretion and action" 0 -0.440711462 0 kegg kegg NA NA no no no no no no Thyroid cancer Hippo signaling pathway - multiple species 0 0 -0.530501931 kegg kegg NA NA no no no no no no Thyroid cancer Inflammatory mediator regulation of TRP channels 0 0 0.492149292 kegg kegg NA NA no no no no no no Thyroid cancer Inositol phosphate metabolism 0 -0.552371542 0 kegg kegg NA NA no no no no no no Thyroid cancer Long-term depression 0 0 0.41981982 kegg kegg NA NA no no no no no no Thyroid cancer Lysine degradation 0 -0.51284585 0 kegg kegg NA NA no no no no no no Thyroid cancer Lysosome 0 0 -0.463063063 kegg kegg NA NA no no no no no no Thyroid cancer Maturity onset diabetes of the young -0.439130435 0 0 kegg kegg NA NA no no no no up no Thyroid cancer Melanogenesis 0 0 0.514800515 kegg kegg NA NA no no no no no no Thyroid cancer Neuroactive ligand-receptor interaction 0 0 -0.405148005 kegg kegg NA NA no no no up up up Thyroid cancer Nicotine addiction 0 -0.516798419 0 kegg kegg NA NA no no no no up up Thyroid cancer Notch signaling pathway 0 -0.543478261 0 kegg kegg NA NA no no no no no no Thyroid cancer Other glycan degradation 0 -0.513833992 0 kegg kegg NA NA no no no no no no Thyroid cancer Other types of O-glycan biosynthesis 0 -0.492094862 0 kegg kegg NA NA no no no no no no Thyroid cancer Pancreatic secretion 0 0 0.418018018 kegg kegg NA NA no no no no no no Thyroid cancer Parabacteroides 0 0 -0.410837249 kegg Genus NA 4.19E-05 no no no no up up Thyroid cancer Pathways in cancer 0 0 0.442471042 kegg kegg NA NA no no no no no no Thyroid cancer Progesterone-mediated oocyte maturation 0 -0.528656126 0 kegg kegg NA NA no no no no no no Thyroid cancer Proteasome -0.52173913 0.477272727 -0.63037323 kegg kegg NA NA no no no no no no Thyroid cancer Regulation of actin cytoskeleton 0 0.459486166 0 kegg kegg NA NA no no no no no no Thyroid cancer Regulation of lipolysis in adipocytes 0 0 0.445817246 kegg kegg NA NA no no no no no no Thyroid cancer Renin secretion 0 0 0.555727156 kegg kegg NA NA no no no no no no Thyroid cancer Selenocompound metabolism 0 -0.438735178 0 kegg kegg NA NA no no no no no no Thyroid cancer Signaling pathways regulating pluripotency of stem cells 0 -0.429841897 0 kegg kegg NA NA no no no no no no Thyroid cancer SNARE interactions in vesicular transport 0 0 -0.467696268 kegg kegg NA NA no no no no no no Thyroid cancer Sphingolipid metabolism 0 0 -0.411840412 kegg kegg NA NA no no no no no no Thyroid cancer Starch and sucrose metabolism 0 0 -0.528957529 kegg kegg NA NA no no no no no no Thyroid cancer Synaptic vesicle cycle 0 0 -0.671299871 kegg kegg NA NA no no no no up up Thyroid cancer Taurine and hypotaurine metabolism 0 -0.561264822 0 kegg kegg NA NA no no no no no no Thyroid cancer Terpenoid backbone biosynthesis -0.451304348 0 0 kegg kegg NA NA no no no no no no Thyroid cancer Tight junction 0 0.464426877 0 kegg kegg NA NA no no no no no no Thyroid cancer Toxoplasmosis -0.483478261 0 0 kegg kegg NA NA no no no no no no Thyroid cancer Type II diabetes mellitus 0 -0.42687747 0 kegg kegg NA NA no no no no no no Thyroid cancer Viral carcinogenesis 0.407826087 0 0 kegg kegg NA NA no no no no no no Thyroid cancer Viral protein interaction with cytokine and cytokine receptor 0 0.425889328 0 kegg kegg NA NA no no no no no no Thyroid cancer Vitamin digestion and absorption 0 0 -0.457142857 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway 2-Oxocarboxylic acid metabolism 0 0.453557312 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway ABC transporters 0 -0.416996047 0 kegg kegg NA NA no no no no up up Thyroid hormone signaling pathway Adherens junction 0.855652174 0.913043478 0.862290862 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Adrenergic signaling in cardiomyocytes 0 0.498023715 0 kegg kegg NA NA no no no no no up Thyroid hormone signaling pathway "Alanine, aspartate and glutamate metabolism" 0 -0.694664032 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway alpha-Linolenic acid metabolism 0 -0.51284585 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Apelin signaling pathway -0.494782609 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Apoptosis - multiple species -0.495652174 -0.507905138 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Arginine and proline metabolism 0 -0.58201581 -0.466666667 kegg kegg NA NA no no no no up no Thyroid hormone signaling pathway Arginine biosynthesis 0 -0.650197628 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Autophagy - animal -0.531304348 -0.754940711 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Autophagy - other -0.731304348 -0.665019763 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Basal transcription factors -0.594782609 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Base excision repair -0.52 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Bifidobacterium 0 0.441804227 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Thyroid hormone signaling pathway Biosynthesis of amino acids 0 -0.423913043 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Butyricicoccus -0.533698579 0 0 butyrate-producing kegg Genus NA 0.852 no no no no no no Thyroid hormone signaling pathway C-type lectin receptor signaling pathway 0 -0.513833992 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Calcium signaling pathway 0 0.630434783 0 kegg kegg NA NA no no no no up up Thyroid hormone signaling pathway Cardiac muscle contraction 0 0.682806324 0.629086229 kegg kegg NA NA no no no no no up Thyroid hormone signaling pathway Circadian entrainment 0 0.56027668 0 kegg kegg NA NA no no no no up up Thyroid hormone signaling pathway Cytokine-cytokine receptor interaction 0 0 0.43011583 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Dopaminergic synapse 0 0.520750988 0 kegg kegg NA NA no no no no up no Thyroid hormone signaling pathway Dorea -0.523478261 0 0 kegg Genus NA 0.00362 no no no up no dn Thyroid hormone signaling pathway Drug metabolism - cytochrome P450 0 0.528656126 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Drug metabolism - other enzymes 0 0.617588933 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway EGFR tyrosine kinase inhibitor resistance -0.426086957 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Fatty acid biosynthesis 0 -0.621541502 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Fatty acid degradation 0 -0.685770751 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Fatty acid metabolism 0 -0.692687747 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Fc epsilon RI signaling pathway 0 -0.431818182 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Focal adhesion 0.834782609 0.813241107 0.803088803 kegg kegg NA NA no no no no up up Thyroid hormone signaling pathway Folate biosynthesis 0 0.523715415 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway FoxO signaling pathway 0 -0.68083004 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway GABAergic synapse 0 -0.542490119 -0.406692407 kegg kegg NA NA no no no no up up Thyroid hormone signaling pathway Gap junction 0.430434783 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Glutathione metabolism 0 0.460474308 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Glycerolipid metabolism 0 -0.460474308 0 kegg kegg NA NA no no no no no up Thyroid hormone signaling pathway Glycerophospholipid metabolism 0 -0.485177866 0 kegg kegg NA NA no no no no no up Thyroid hormone signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.473320158 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.431818182 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0 0.45256917 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Glyoxylate and dicarboxylate metabolism 0 -0.662055336 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Hematopoietic cell lineage 0 0 0.52972973 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway HIF-1 signaling pathway -0.583478261 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Hippo signaling pathway 0.833913043 0.884387352 0.89009009 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Hippo signaling pathway - multiple species 0 -0.537549407 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway IL-17 signaling pathway 0 0 -0.413384813 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Inflammatory mediator regulation of TRP channels 0 0.572134387 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Inositol phosphate metabolism 0 -0.447628458 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Insulin signaling pathway -0.51826087 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway JAK-STAT signaling pathway 0 -0.605731225 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Lachnospira 0 0.515443554 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Thyroid hormone signaling pathway Leukocyte transendothelial migration 0.760869565 0.549407115 0.441698842 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway MAPK signaling pathway 0 -0.611660079 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Melanogenesis 0.451304348 0.584980237 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Metabolism of xenobiotics by cytochrome P450 0 0.51284585 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Mitophagy - animal 0 0 -0.439382239 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway mTOR signaling pathway -0.455652174 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Mucin type O-glycan biosynthesis 0 -0.651185771 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway N-Glycan biosynthesis 0 0.515810277 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway NF-kappa B signaling pathway 0 -0.605731225 -0.447104247 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Nicotinate and nicotinamide metabolism 0 -0.546442688 -0.413384813 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Nitrogen metabolism 0 -0.634387352 -0.454311454 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway NOD-like receptor signaling pathway 0 -0.690711462 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Osteoclast differentiation 0 -0.539525692 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Ovarian steroidogenesis 0.46173913 0 0 kegg kegg NA NA no no no no up up Thyroid hormone signaling pathway Oxidative phosphorylation 0 0.652173913 0.584041184 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway p53 signaling pathway -0.549565217 -0.499011858 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Pantothenate and CoA biosynthesis 0 -0.625494071 0 kegg kegg NA NA no no no no no dn Thyroid hormone signaling pathway Paraprevotella 0 0.433868154 0 kegg Genus NA 0.118 no no no no no no Thyroid hormone signaling pathway Peroxisome 0 -0.687747036 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Phenylalanine metabolism 0.433043478 0.52173913 0.52046332 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway PI3K-Akt signaling pathway -0.479130435 0 0 yes kegg kegg NA NA no no no no up up Thyroid hormone signaling pathway Platelet activation 0.82173913 0.852766798 0.684427284 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Platinum drug resistance -0.513043478 -0.419960474 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway PPAR signaling pathway 0 -0.583992095 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Progesterone-mediated oocyte maturation -0.435652174 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Proteasome -0.485217391 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Protein export -0.468695652 0.476284585 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Purine metabolism 0 0 -0.489317889 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Rap1 signaling pathway 0.833043478 0.834980237 0.654568855 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Ras signaling pathway 0 0.53458498 0 yes kegg kegg NA NA no no no no up up Thyroid hormone signaling pathway Regulation of actin cytoskeleton 0.426086957 0.431818182 0.416731017 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Retrograde endocannabinoid signaling 0 0.628458498 0.453796654 kegg kegg NA NA no no no no no up Thyroid hormone signaling pathway Ribosome 0 0.482213439 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Ribosome biogenesis in eukaryotes -0.446956522 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway RIG-I-like receptor signaling pathway -0.46173913 -0.647233202 -0.463320463 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway RNA degradation 0 0.475296443 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway RNA polymerase -0.596521739 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway RNA transport -0.475652174 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Selenocompound metabolism -0.517391304 0 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway SNARE interactions in vesicular transport 0 -0.609683794 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Spliceosome -0.673913043 -0.418972332 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Starch and sucrose metabolism 0 -0.592885375 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway T cell receptor signaling pathway 0 -0.65513834 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway TGF-beta signaling pathway 0 0.421936759 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Thermogenesis 0 0.647233202 0.50965251 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Thiamine metabolism 0 0 -0.504504505 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Tight junction 0.651304348 0.726284585 0.404375804 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway TNF signaling pathway 0 -0.433794466 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Toll-like receptor signaling pathway 0 -0.501976285 0 yes kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Vascular smooth muscle contraction 0 0.600790514 0 kegg kegg NA NA no no no no no no Thyroid hormone signaling pathway Wnt signaling pathway 0 0.584980237 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis 2-Oxocarboxylic acid metabolism 0 0 -0.405920206 kegg kegg NA NA no no no no no no Thyroid hormone synthesis ABC transporters -0.44 0 0 kegg kegg NA NA no no no no up up Thyroid hormone synthesis Adrenergic signaling in cardiomyocytes 0.500869565 0.757905138 0 kegg kegg NA NA no no no no no up Thyroid hormone synthesis "Alanine, aspartate and glutamate metabolism" -0.53826087 -0.422924901 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis alpha-Linolenic acid metabolism -0.411304348 -0.42687747 -0.478249678 kegg kegg NA NA no no no no no no Thyroid hormone synthesis AMPK signaling pathway 0.699130435 0.604743083 0.623423423 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Apoptosis -0.492173913 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Arachidonic acid metabolism 0.409565217 0 0.673359073 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Arginine and proline metabolism -0.673913043 0 0 kegg kegg NA NA no no no no up no Thyroid hormone synthesis Arginine biosynthesis -0.58 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Ascorbate and aldarate metabolism 0 0 -0.652509653 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Autophagy - animal -0.456521739 0 -0.454826255 kegg kegg NA NA no no no no no no Thyroid hormone synthesis B cell receptor signaling pathway -0.497391304 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Biosynthesis of amino acids 0 -0.625494071 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Biosynthesis of cofactors 0.550434783 0.422924901 0.706563707 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Blautia 0 -0.445652174 0 acetate-producing kegg Genus NA 1.36E-05 no no no up dn dn Thyroid hormone synthesis C-type lectin receptor signaling pathway -0.420869565 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Calcium signaling pathway 0.448695652 0.774703557 0 kegg kegg NA NA no no no no up up Thyroid hormone synthesis Carbon metabolism 0 -0.606719368 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Cardiac muscle contraction 0 0.583003953 0 kegg kegg NA NA no no no no no up Thyroid hormone synthesis Cell adhesion molecules 0 -0.60770751 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Cellular senescence 0 -0.419960474 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis cGMP-PKG signaling pathway -0.593913043 -0.541501976 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Circadian entrainment 0.559130435 0.532608696 0.751866152 kegg kegg NA NA no no no no up up Thyroid hormone synthesis Citrate cycle (TCA cycle) 0 0 -0.553410553 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Complement and coagulation cascades 0 -0.518774704 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Dopaminergic synapse 0.468695652 0.758893281 0.468983269 kegg kegg NA NA no no no no up no Thyroid hormone synthesis Drug metabolism - other enzymes 0 0 -0.535907336 kegg kegg NA NA no no no no no no Thyroid hormone synthesis ECM-receptor interaction 0.445217391 0 0 kegg kegg NA NA no no no no up up Thyroid hormone synthesis Endocrine resistance 0.584347826 0.720355731 0.567567568 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Endocytosis 0 -0.58201581 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis ErbB signaling pathway 0 0 -0.425482625 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Fatty acid biosynthesis -0.622608696 -0.506916996 -0.429343629 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Fatty acid degradation -0.613043478 -0.630434783 -0.545173745 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Fatty acid metabolism -0.55826087 -0.660079051 -0.455598456 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Fc epsilon RI signaling pathway 0 -0.459486166 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Fc gamma R-mediated phagocytosis -0.772173913 -0.723320158 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Ferroptosis 0.466956522 0.43083004 0.583011583 kegg kegg NA NA no no no no no no Thyroid hormone synthesis FoxO signaling pathway -0.490434783 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis GABAergic synapse -0.427826087 0 0 kegg kegg NA NA no no no no up up Thyroid hormone synthesis Galactose metabolism 0 -0.565217391 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Gap junction 0.711304348 0.66798419 0.724581725 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Glutamatergic synapse 0.493043478 0 0.614157014 kegg kegg NA NA no no no no up up Thyroid hormone synthesis Glutathione metabolism 0.613043478 0.633399209 0.760617761 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Glycerolipid metabolism -0.513043478 0 -0.498326898 kegg kegg NA NA no no no no no up Thyroid hormone synthesis Glycerophospholipid metabolism 0 0 -0.469240669 kegg kegg NA NA no no no no no up Thyroid hormone synthesis "Glycine, serine and threonine metabolism" 0.686956522 0.494071146 0.718404118 kegg kegg NA NA no no no no up no Thyroid hormone synthesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate -0.52173913 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.507335907 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Glycosaminoglycan degradation 0 -0.519762846 -0.545431145 kegg kegg NA NA no no no no no up Thyroid hormone synthesis Glyoxylate and dicarboxylate metabolism -0.563478261 -0.432806324 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis GnRH signaling pathway 0.746956522 0.787549407 0.582496782 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Hippo signaling pathway - multiple species -0.666086957 0 -0.510682111 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Histidine metabolism 0 0 -0.495495495 kegg kegg NA NA no no no no no no Thyroid hormone synthesis IL-17 signaling pathway -0.684347826 -0.53458498 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Inflammatory mediator regulation of TRP channels 0.673043478 0.644268775 0.45019305 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Inositol phosphate metabolism -0.414782609 0 -0.453024453 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Insulin secretion 0.790434783 0.900197628 0.658172458 yes kegg kegg NA NA no no no no up up Thyroid hormone synthesis JAK-STAT signaling pathway -0.553043478 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Long-term depression 0.566956522 0.710474308 0.703474903 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Longevity regulating pathway 0 0 0.588416988 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Longevity regulating pathway - multiple species 0 -0.734189723 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Lysosome -0.515652174 -0.580039526 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis MAPK signaling pathway -0.486086957 -0.42687747 -0.651737452 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Melanogenesis 0.656521739 0.701581028 0.512226512 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Mitophagy - animal 0.670434783 0.688735178 0.561132561 kegg kegg NA NA no no no no no no Thyroid hormone synthesis mRNA surveillance pathway 0 0.523715415 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Natural killer cell mediated cytotoxicity 0 -0.501976285 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Necroptosis 0.553913043 0.540513834 0.564993565 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Neuroactive ligand-receptor interaction -0.555652174 -0.682806324 0 kegg kegg NA NA no no no up up up Thyroid hormone synthesis Neutrophil extracellular trap formation -0.606086957 -0.567193676 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis NF-kappa B signaling pathway -0.650434783 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Nicotinate and nicotinamide metabolism -0.731304348 -0.442687747 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Nitrogen metabolism -0.442608696 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis NOD-like receptor signaling pathway -0.824347826 -0.514822134 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Notch signaling pathway 0 0 -0.514285714 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Odoribacter 0 -0.492324442 0 butyrate-producing kegg Genus NA 0.798 no no no no no no Thyroid hormone synthesis Olfactory transduction -0.713043478 -0.557312253 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Oscillospira 0 -0.447628458 0 LPS-producing kegg Genus NA 0.62 no no no no no no Thyroid hormone synthesis Osteoclast differentiation -0.842608696 -0.635375494 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Other glycan degradation 0 0 -0.503217503 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Ovarian steroidogenesis 0.66173913 0.822134387 0.71969112 kegg kegg NA NA no no no no up up Thyroid hormone synthesis Oxidative phosphorylation 0 0.58201581 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Pantothenate and CoA biosynthesis -0.76173913 -0.581027668 0 kegg kegg NA NA no no no no no dn Thyroid hormone synthesis Pentose phosphate pathway -0.412173913 -0.608695652 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Peroxisome -0.687826087 -0.668972332 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Phagosome 0 -0.600790514 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Porphyrin and chlorophyll metabolism 0.657391304 0.446640316 0.731274131 kegg kegg NA NA no no no no no no Thyroid hormone synthesis PPAR signaling pathway -0.472173913 -0.540513834 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Progesterone-mediated oocyte maturation 0 0 -0.601287001 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Proteasome 0 0 -0.466666667 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Protein processing in endoplasmic reticulum 0.637391304 0.458498024 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Purine metabolism 0.696521739 0.538537549 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Renin-angiotensin system -0.56173913 -0.652173913 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Retinol metabolism 0 0 -0.458944659 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Retrograde endocannabinoid signaling 0 0.571146245 0 kegg kegg NA NA no no no no no up Thyroid hormone synthesis Ribosome 0.479130435 0.479249012 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis RIG-I-like receptor signaling pathway -0.480869565 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis RNA degradation 0 0.416007905 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Ruminococcus 0.523478261 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Thyroid hormone synthesis Selenocompound metabolism 0 0 -0.432175032 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Serotonergic synapse 0 0.486166008 0.621621622 kegg kegg NA NA no no no no no no Thyroid hormone synthesis SNARE interactions in vesicular transport -0.435652174 0 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Sphingolipid metabolism 0 0 -0.440669241 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Sphingolipid signaling pathway 0 -0.47826087 -0.635778636 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Starch and sucrose metabolism -0.665217391 -0.565217391 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Steroid hormone biosynthesis 0 0 -0.454568855 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Sulfur metabolism 0 0 0.498841699 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Synaptic vesicle cycle -0.672173913 -0.603754941 0 kegg kegg NA NA no no no no up up Thyroid hormone synthesis Terpenoid backbone biosynthesis 0 0 -0.417245817 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Th1 and Th2 cell differentiation 0 -0.5 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Th17 cell differentiation 0 -0.529644269 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Thermogenesis 0 0.556324111 0 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Toll-like receptor signaling pathway -0.415652174 0 0 yes kegg kegg NA NA no no no no no no Thyroid hormone synthesis Tryptophan metabolism 0 0 -0.453024453 kegg kegg NA NA no no no no up no Thyroid hormone synthesis Ubiquitin mediated proteolysis 0.728695652 0.699604743 0.546718147 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Various types of N-glycan biosynthesis 0 0 -0.418018018 kegg kegg NA NA no no no no no no Thyroid hormone synthesis Vascular smooth muscle contraction 0.584347826 0.587944664 0.689060489 kegg kegg NA NA no no no no no no Thyroid hormone synthesis VEGF signaling pathway 0 0 -0.598455598 kegg kegg NA NA no no no no no no Tight junction ABC transporters 0 -0.695652174 0 kegg kegg NA NA no no no no up up Tight junction Adherens junction 0.86173913 0.883399209 0.700643501 kegg kegg NA NA no no no no no no Tight junction "Alanine, aspartate and glutamate metabolism" 0 -0.537549407 0 kegg kegg NA NA no no no no no no Tight junction alpha-Linolenic acid metabolism 0 -0.424901186 0 kegg kegg NA NA no no no no no no Tight junction Apelin signaling pathway 0 0.419960474 0 kegg kegg NA NA no no no no no no Tight junction Apoptosis 0.442608696 0 0.42033462 kegg kegg NA NA no no no no no no Tight junction Apoptosis - multiple species -0.662608696 -0.677865613 0 kegg kegg NA NA no no no no no no Tight junction Arachidonic acid metabolism 0 0 0.594594595 kegg kegg NA NA no no no no no no Tight junction Arginine and proline metabolism 0 -0.43972332 0 kegg kegg NA NA no no no no up no Tight junction Arginine biosynthesis 0 -0.450592885 0 kegg kegg NA NA no no no no no no Tight junction Autophagy - animal -0.742608696 -0.791501976 -0.470527671 kegg kegg NA NA no no no no no no Tight junction Autophagy - other -0.762608696 -0.786561265 -0.728957529 kegg kegg NA NA no no no no no no Tight junction Basal transcription factors -0.626086957 0 -0.444015444 kegg kegg NA NA no no no no no no Tight junction Base excision repair -0.519130435 0 0 kegg kegg NA NA no no no no no no Tight junction beta-Alanine metabolism 0 0.423913043 0.405405405 kegg kegg NA NA no no no no no no Tight junction Bifidobacterium 0 0.503716255 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Tight junction Biosynthesis of amino acids 0 0 0.527670528 kegg kegg NA NA no no no no no no Tight junction Biosynthesis of cofactors 0.416521739 0 0 kegg kegg NA NA no no no no no no Tight junction Calcium signaling pathway 0 0 -0.432175032 kegg kegg NA NA no no no no up up Tight junction Carbon metabolism 0.426086957 0.592885375 0.57014157 kegg kegg NA NA no no no no no no Tight junction Cardiac muscle contraction 0 0.506916996 0 kegg kegg NA NA no no no no no up Tight junction Cell cycle 0 0 -0.456370656 kegg kegg NA NA no no no no no no Tight junction Citrate cycle (TCA cycle) 0 0.468379447 0 kegg kegg NA NA no no no no no no Tight junction Clostridium 0 0.538948096 0 kegg Genus NA 0.925 no no no no no no Tight junction Cytokine-cytokine receptor interaction 0 0 0.508108108 kegg kegg NA NA no no no no no no Tight junction Drug metabolism - cytochrome P450 0 0.552371542 0 kegg kegg NA NA no no no no no no Tight junction Drug metabolism - other enzymes 0 0.700592885 0 kegg kegg NA NA no no no no no no Tight junction ErbB signaling pathway -0.586086957 -0.705533597 -0.616731017 kegg kegg NA NA no no no no no no Tight junction Fatty acid biosynthesis 0 -0.507905138 0 kegg kegg NA NA no no no no no no Tight junction Fatty acid degradation 0 -0.496047431 0 kegg kegg NA NA no no no no no no Tight junction Fatty acid elongation 0.425217391 0.462450593 0.469240669 kegg kegg NA NA no no no no no no Tight junction Focal adhesion 0.773913043 0.915019763 0.574259974 kegg kegg NA NA no no no no up up Tight junction FoxO signaling pathway -0.634782609 -0.798418972 0 kegg kegg NA NA no no no no no no Tight junction Fructose and mannose metabolism 0 -0.507905138 0 kegg kegg NA NA no no no no no no Tight junction Galactose metabolism 0 -0.434782609 0 kegg kegg NA NA no no no no no no Tight junction Glutathione metabolism 0 0.416996047 0.456885457 kegg kegg NA NA no no no no no no Tight junction Glycerolipid metabolism 0 -0.722332016 -0.415701416 kegg kegg NA NA no no no no no up Tight junction Glycerophospholipid metabolism -0.409565217 -0.726284585 -0.44041184 kegg kegg NA NA no no no no no up Tight junction Glycolysis / Gluconeogenesis 0 0.639328063 0.451994852 kegg kegg NA NA no no no no no no Tight junction Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.686758893 0 kegg kegg NA NA no no no no no no Tight junction Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.637391304 0 0 kegg kegg NA NA no no no no no no Tight junction Glycosaminoglycan biosynthesis - keratan sulfate 0 0 -0.432432432 kegg kegg NA NA no no no no no no Tight junction Glyoxylate and dicarboxylate metabolism 0 -0.437747036 0 kegg kegg NA NA no no no no no no Tight junction Hedgehog signaling pathway 0 0 -0.60952381 kegg kegg NA NA no no no no no no Tight junction HIF-1 signaling pathway 0 0.428853755 0 kegg kegg NA NA no no no no no no Tight junction Hippo signaling pathway 0.80173913 0.825098814 0.523294723 kegg kegg NA NA no no no no no no Tight junction Hippo signaling pathway - multiple species 0 -0.438735178 0 kegg kegg NA NA no no no no no no Tight junction Homologous recombination 0 -0.584980237 0 kegg kegg NA NA no no no no no no Tight junction Inositol phosphate metabolism 0 -0.721343874 0 kegg kegg NA NA no no no no no no Tight junction Lachnospira 0 0.653817663 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Tight junction Longevity regulating pathway 0 -0.4743083 0 kegg kegg NA NA no no no no no no Tight junction Lysine degradation -0.417391304 -0.555335968 -0.561647362 kegg kegg NA NA no no no no no no Tight junction Mannose type O-glycan biosynthesis 0 0 -0.493693694 kegg kegg NA NA no no no no no no Tight junction MAPK signaling pathway 0 -0.664031621 0 kegg kegg NA NA no no no no no no Tight junction Metabolism of xenobiotics by cytochrome P450 0 0.617588933 0.407207207 kegg kegg NA NA no no no no no no Tight junction mRNA surveillance pathway 0 0 -0.558043758 kegg kegg NA NA no no no no no no Tight junction Mucin type O-glycan biosynthesis 0 -0.555335968 0 kegg kegg NA NA no no no no no no Tight junction Neuroactive ligand-receptor interaction 0 0 0.426769627 kegg kegg NA NA no no no up up up Tight junction NF-kappa B signaling pathway -0.433043478 -0.684782609 -0.605405405 kegg kegg NA NA no no no no no no Tight junction Nitrogen metabolism 0 -0.438735178 0 kegg kegg NA NA no no no no no no Tight junction Non-homologous end-joining 0 0.43083004 0 kegg kegg NA NA no no no no no no Tight junction Notch signaling pathway 0 -0.540513834 0 kegg kegg NA NA no no no no no no Tight junction Oocyte meiosis 0 0.508893281 0 kegg kegg NA NA no no no no no no Tight junction Other glycan degradation 0 -0.588932806 0 kegg kegg NA NA no no no no no no Tight junction Other types of O-glycan biosynthesis -0.466086957 -0.58201581 -0.545945946 kegg kegg NA NA no no no no no no Tight junction Oxidative phosphorylation 0 0.559288538 0 kegg kegg NA NA no no no no no no Tight junction p53 signaling pathway -0.692173913 -0.71541502 -0.485971686 kegg kegg NA NA no no no no no no Tight junction Pentose phosphate pathway 0.424347826 0 0.443243243 kegg kegg NA NA no no no no no no Tight junction Phagosome 0 0 0.516859717 kegg kegg NA NA no no no no no no Tight junction Phenylalanine metabolism 0.609565217 0.552371542 0 kegg kegg NA NA no no no no no no Tight junction Phosphatidylinositol signaling system -0.435652174 0 -0.482368082 kegg kegg NA NA no no no no no no Tight junction Phospholipase D signaling pathway 0 -0.495059289 0 kegg kegg NA NA no no no no up up Tight junction Platinum drug resistance -0.772173913 -0.660079051 -0.414671815 kegg kegg NA NA no no no no no no Tight junction Prevotella 0 -0.420766661 0 acetate-producing kegg Genus NA 0.287 no no no no no no Tight junction Primary bile acid biosynthesis 0 0.464426877 0.443500644 kegg kegg NA NA no no no no no no Tight junction Proteasome 0 0.663043478 0 kegg kegg NA NA no no no no no no Tight junction Protein export -0.410434783 0.555335968 0 kegg kegg NA NA no no no no no no Tight junction Rap1 signaling pathway 0.708695652 0.801383399 0.611325611 kegg kegg NA NA no no no no no no Tight junction Ras signaling pathway 0 0.471343874 0 yes kegg kegg NA NA no no no no up up Tight junction Ribosome 0 0.446640316 0 kegg kegg NA NA no no no no no no Tight junction Ribosome biogenesis in eukaryotes -0.517391304 0 -0.445302445 kegg kegg NA NA no no no no no no Tight junction RNA degradation 0 0 -0.516859717 kegg kegg NA NA no no no no no no Tight junction RNA polymerase -0.63826087 0 0 kegg kegg NA NA no no no no no no Tight junction Ruminococcus 0 0.44675719 0 kegg Genus NA 0.0679 no no no no no dn Tight junction Selenocompound metabolism -0.523478261 -0.504940711 0 kegg kegg NA NA no no no no no no Tight junction SNARE interactions in vesicular transport 0 -0.661067194 0 kegg kegg NA NA no no no no no no Tight junction Sphingolipid metabolism 0.419130435 0 0 kegg kegg NA NA no no no no no no Tight junction Spliceosome -0.731304348 -0.695652174 -0.613384813 kegg kegg NA NA no no no no no no Tight junction Starch and sucrose metabolism 0 -0.451581028 0 kegg kegg NA NA no no no no no no Tight junction Steroid hormone biosynthesis 0.408695652 0 0 kegg kegg NA NA no no no no no no Tight junction Sulfur metabolism 0.606086957 0.436758893 0 kegg kegg NA NA no no no no no no Tight junction Taurine and hypotaurine metabolism -0.472173913 -0.820158103 -0.622651223 kegg kegg NA NA no no no no no no Tight junction TGF-beta signaling pathway 0 0.528656126 0 kegg kegg NA NA no no no no no no Tight junction Tryptophan metabolism 0 0.470355731 0 kegg kegg NA NA no no no no up no Tight junction Tyrosine metabolism 0 0 0.408236808 kegg kegg NA NA no no no no no no Tight junction Various types of N-glycan biosynthesis 0 0 -0.407207207 kegg kegg NA NA no no no no no no Tight junction Vascular smooth muscle contraction 0 0.671936759 0 kegg kegg NA NA no no no no no no Tight junction Viral protein interaction with cytokine and cytokine receptor 0 0 0.491377091 kegg kegg NA NA no no no no no no TLCA+stool 12-ketoDCA+stool 0 0 -0.510090409 stool_bileacids stool_bileacids 0.243 0.505 no no no no no no TLCA+stool Acetic acid+stool 0 0.647233747 0 yes stool_bileacids stool_scfa 0.243 0.0656 no no no dn no no TLCA+stool Akkermansia 0.595782718 0 0 acetate-producing stool_bileacids Genus 0.243 0.23 no no no no no no TLCA+stool DCA+stool 0 -0.63943575 0 stool_bileacids stool_bileacids 0.243 0.195 no no no no no no TLCA+stool Faecalibacterium -0.749780076 0 0 butyrate-producing stool_bileacids Genus 0.243 0.0039 no no no no dn dn TLCA+stool GUDCA+stool 0 0.611809979 0 yes stool_bileacids stool_bileacids 0.243 0.0085 no no no no dn no TLCA+stool Intestinal immune network for IgA production 0.491163304 0 0 stool_bileacids kegg 0.243 NA no no no no no no TLCA+stool L-Tryptophan+stool 0 0.600445765 0 stool_bileacids stool_cometabolism 0.243 0.557 no no no no no no TLCA+stool LCA+stool 0 0 -0.451169074 stool_bileacids stool_bileacids 0.243 0.314 no no no no no no TLCA+stool Ruminococcus 0.521601686 0 0 stool_bileacids Genus 0.243 0.0679 no no no no no dn TLCA+stool T-¦Á-MCA+stool -0.573850174 0 0 stool_bileacids stool_bileacids 0.243 0.48 no no no no no no TMAO+blood "12,13-EPOME+blood" 0 -0.494796364 0 serum_choline serum_ARA 0.00706 0.901 up up no no no no TMAO+blood 14:0-LPC+blood 0 -0.598039216 0 serum_choline serum_phospholipids 0.00706 0.00689 up up no up up no TMAO+blood 14:0/16:0-PC+blood 0 -0.487745098 0 serum_choline serum_phospholipids 0.00706 0.0358 up up no no up no TMAO+blood 14:0/18:0-PC+blood 0 -0.580882353 0 serum_choline serum_phospholipids 0.00706 0.00289 up up no up up no TMAO+blood 14:0/18:2-PC+blood -0.517293233 -0.580882353 0 serum_choline serum_phospholipids 0.00706 0.102 up up no no up no TMAO+blood 14:0+blood -0.460150376 0 0 yes serum_choline serum_fattyacid 0.00706 0.00572 up up no up no dn TMAO+blood 16:0/14:0-PC+blood 0.511278195 0 0 serum_choline serum_phospholipids 0.00706 0.0206 up up no no up up TMAO+blood 16:0/16:0-PI+blood -0.452631579 0 0 serum_choline serum_phospholipids 0.00706 0.358 up up no no no no TMAO+blood 16:0/16:1-PC+blood 0 -0.566176471 0 serum_choline serum_phospholipids 0.00706 0.00283 up up no up up no TMAO+blood 16:0/16:1-PI+blood -0.577443609 0 0 serum_choline serum_phospholipids 0.00706 0.262 up up no no no no TMAO+blood 16:0/18:2-PI+blood 0 -0.693627451 0 serum_choline serum_phospholipids 0.00706 0.269 up up no no no no TMAO+blood 16:0/20:4-PC+blood 0.753383459 0 0 serum_choline serum_phospholipids 0.00706 0.0262 up up no no up no TMAO+blood 16:0/22:6-PE+blood 0 -0.512254902 0 serum_choline serum_phospholipids 0.00706 0.000934 up up no up up no TMAO+blood 16:1/16:0-PC+blood 0 0.551470588 0 serum_choline serum_phospholipids 0.00706 0.0215 up up no no up up TMAO+blood 18:0-LPE+blood 0 0 -0.667008547 serum_choline serum_phospholipids 0.00706 0.491 up up no no no no TMAO+blood 18:0/16:0-PC+blood 0 0.519607843 0 serum_choline serum_phospholipids 0.00706 9.64E-07 up up no up up up TMAO+blood 18:0/18:0-PE+blood 0 -0.580882353 0 serum_choline serum_phospholipids 0.00706 0.00896 up up no up up no TMAO+blood 18:0/18:1-PE+blood 0 -0.637254902 0 serum_choline serum_phospholipids 0.00706 0.00716 up up no up up no TMAO+blood 18:0/20:4-PC+blood 0.673684211 0 0 serum_choline serum_phospholipids 0.00706 0.454 up up no no no no TMAO+blood 18:0/20:5-PC+blood 0 0.595588235 0 serum_choline serum_phospholipids 0.00706 0.17 up up no no no no TMAO+blood 18:0/22:6-PI+blood -0.523308271 0 0.412649573 serum_choline serum_phospholipids 0.00706 0.425 up up no no no no TMAO+blood 18:1-LPC+blood 0 0.517156863 0 serum_choline serum_phospholipids 0.00706 0.179 up up no no no no TMAO+blood 18:1-LPE+blood 0 0 -0.414700855 serum_choline serum_phospholipids 0.00706 0.117 up up no no no no TMAO+blood 18:1/16:0-PE+blood 0 -0.504901961 0 serum_choline serum_phospholipids 0.00706 0.000182 up up no up up no TMAO+blood 18:1/16:1-PE+blood 0 -0.512254902 0 serum_choline serum_phospholipids 0.00706 0.000184 up up no up up no TMAO+blood 18:1/18:0-PE+blood 0 -0.610294118 0 serum_choline serum_phospholipids 0.00706 1.39E-06 up up no up up no TMAO+blood 18:1/18:1-PE+blood 0 -0.617647059 0 serum_choline serum_phospholipids 0.00706 1.03E-05 up up no up up no TMAO+blood 18:1/18:2-PE+blood 0 -0.588235294 -0.500854701 serum_choline serum_phospholipids 0.00706 0.000293 up up no up up no TMAO+blood 18:1/20:4-PC+blood 0.470676692 0.551470588 0 serum_choline serum_phospholipids 0.00706 0.582 up up no no no no TMAO+blood 18:1/20:4-PE+blood 0 -0.492647059 0 serum_choline serum_phospholipids 0.00706 0.0578 up up no up no no TMAO+blood 18:2/18:1-PC+blood 0 -0.507352941 0 serum_choline serum_phospholipids 0.00706 2.30E-05 up up no dn up up TMAO+blood 18:2/18:2-PC+blood 0 -0.529411765 0 serum_choline serum_phospholipids 0.00706 1.98E-05 up up no dn up up TMAO+blood 18:2/18:2-PS+blood 0 -0.558823529 0 serum_choline serum_phospholipids 0.00706 0.00674 up up no up up no TMAO+blood 18:3/16:0-PE+blood 0 -0.828431373 0 serum_choline serum_phospholipids 0.00706 0.00149 up up no up up no TMAO+blood 20:0/20:4-PE+blood 0 -0.769607843 -0.505641026 serum_choline serum_phospholipids 0.00706 0.00128 up up no up up no TMAO+blood 20:1/20:4-PC+blood 0 0.507352941 0 serum_choline serum_phospholipids 0.00706 0.0419 up up no no no up TMAO+blood 20:1/20:4-PE+blood 0 -0.598039216 -0.406495726 serum_choline serum_phospholipids 0.00706 0.0042 up up no up up no TMAO+blood 20:1+blood 0 0.5 0 yes serum_choline serum_fattyacid 0.00706 2.56E-05 up up no dn dn dn TMAO+blood 20:2/18:1-PE+blood 0 -0.68627451 0 serum_choline serum_phospholipids 0.00706 0.00208 up up no up up no TMAO+blood 20:2/18:3-PE+blood 0 0 -0.567863248 serum_choline serum_phospholipids 0.00706 0.0391 up up no up up no TMAO+blood 20:3-LPE+blood 0 0 -0.532991453 serum_choline serum_phospholipids 0.00706 0.084 up up no no up no TMAO+blood 20:3/16:0-PC+blood 0.720300752 0 0 serum_choline serum_phospholipids 0.00706 0.00405 up up no no up up TMAO+blood 20:4-LPA+blood 0 0.605392157 0 serum_choline serum_phospholipids 0.00706 0.398 up up no no no no TMAO+blood 20:4-LPC+blood 0.445112782 0 0 serum_choline serum_phospholipids 0.00706 0.949 up up no no no no TMAO+blood 20:4-LPE+blood 0 0 -0.446153846 serum_choline serum_phospholipids 0.00706 0.552 up up no no no no TMAO+blood 20:4/16:0-PE+blood 0 -0.654411765 0 serum_choline serum_phospholipids 0.00706 0.00529 up up no no up up TMAO+blood 20:4/18:0-PE+blood 0 0 -0.437264957 serum_choline serum_phospholipids 0.00706 0.000755 up up no up up no TMAO+blood 20:5-LPC+blood 0 0 0.451623932 serum_choline serum_phospholipids 0.00706 0.558 up up no no no no TMAO+blood 22:0/16:0-PE+blood 0 0.492647059 0 serum_choline serum_phospholipids 0.00706 0.091 up up no no no up TMAO+blood 22:6-LPC+blood -0.472180451 0 0.591794872 serum_choline serum_phospholipids 0.00706 0.127 up up no no no up TMAO+blood 22:6n3+blood -0.482706767 0 0.546666667 serum_choline serum_fattyacid 0.00706 0.792 up up no no no no TMAO+blood 4-hydroxybenzoic acid+stool 0 0 -0.458646617 serum_choline stool_cometabolism 0.00706 0.0536 up up no no dn no TMAO+blood 8-HETE+blood 0 0.492647059 0 serum_choline serum_ARA 0.00706 0.741 up up no no no no TMAO+blood Axon guidance 0 -0.523529412 -0.433846154 serum_choline kegg 0.00706 NA up up no no up up TMAO+blood Bacteroides 0 0 0.564444444 LPS-producing serum_choline Genus 0.00706 0.000267 up up no dn dn up TMAO+blood cGMP-PKG signaling pathway 0 0 -0.429230769 serum_choline kegg 0.00706 NA up up no no no no TMAO+blood Collinsella -0.462349922 0 0 serum_choline Genus 0.00706 0.128 up up no no no no TMAO+blood d18:1-18:0-SM+blood 0 0.49754902 0 serum_choline serum_phospholipids 0.00706 0.97 up up no no no no TMAO+blood Dopaminergic synapse 0 -0.555882353 0 serum_choline kegg 0.00706 NA up up no no up no TMAO+blood DPA+blood -0.551879699 0 0 serum_choline serum_ARA 0.00706 0.519 up up no no no no TMAO+blood EPA+blood 0 0 0.466666667 serum_choline serum_ARA 0.00706 0.212 up up no no no no TMAO+blood Gemmiger 0 0 0.506507592 butyrate-producing serum_choline Genus 0.00706 0.595 up up no no no no TMAO+blood Glycine+blood 0.584962406 0 0 serum_choline serum_aminoacids 0.00706 0.00408 up up no dn no up TMAO+blood HCA+blood 0 -0.496049013 0 serum_choline serum_bileacids 0.00706 0.544 up up no no no no TMAO+blood HDCA+blood 0 0 0.543040649 serum_choline serum_bileacids 0.00706 0.483 up up no no no no TMAO+blood heptanoic acid C7+blood 0 0 0.405811966 serum_choline serum_mcfa 0.00706 8.27E-11 up up no dn dn no TMAO+blood iso-LCA+blood 0 0 0.454236336 serum_choline serum_bileacids 0.00706 0.507 up up no no no no TMAO+blood isocapric acid iso-C6+blood 0 0 -0.404444444 serum_choline serum_scfa 0.00706 0.0458 up up no no no dn TMAO+blood L-2-Aminobutyric acid+blood 0 0.514705882 0 yes serum_choline serum_aminoacids 0.00706 0.000328 up up no up up no TMAO+blood L-Asparagine+blood 0 0.5 0 serum_choline serum_aminoacids 0.00706 0.784 up up no no no no TMAO+blood L-Aspartic acid+blood 0.560902256 0 0.485128205 yes serum_choline serum_aminoacids 0.00706 0.0226 up up no up up no TMAO+blood L-Glutamine+blood 0.554887218 0.568627451 0 serum_choline serum_aminoacids 0.00706 0.639 up up no no no no TMAO+blood L-Histidine+blood 0 0.539215686 0 serum_choline serum_aminoacids 0.00706 0.109 up up no no no no TMAO+blood L-Ornithine+blood 0 0 0.491965812 serum_choline serum_aminoacids 0.00706 0.175 up up no no no no TMAO+blood L-Phenylalanine+stool 0 0 0.494736842 serum_choline stool_cometabolism 0.00706 0.398 up up no no no no TMAO+blood L-Threonine+blood 0 0.539215686 -0.442735043 serum_choline serum_aminoacids 0.00706 0.0538 up up no dn no up TMAO+blood L-Tryptophan+stool 0 0 0.535338346 serum_choline stool_cometabolism 0.00706 0.557 up up no no no no TMAO+blood L-Tyrosine+stool 0 0 0.457142857 serum_choline stool_cometabolism 0.00706 0.44 up up no no no no TMAO+blood lauric acid C12+blood 0.586466165 0 0.405128205 serum_choline serum_mcfa 0.00706 0.015 up up no no dn dn TMAO+blood LCA+blood 0 0 0.524057263 serum_choline serum_bileacids 0.00706 0.884 up up no no no no TMAO+blood Legionellosis -0.466666667 0 0 serum_choline kegg 0.00706 NA up up no no no no TMAO+blood Measles 0 0 0.413846154 serum_choline kegg 0.00706 NA up up no no no no TMAO+blood MUFA%+blood 0 0.573529412 0 serum_choline serum_fattyacid 0.00706 0.00142 up up no up no dn TMAO+blood n3+blood 0 0 0.641709402 serum_choline serum_fattyacid 0.00706 0.806 up up no no no no TMAO+blood n6/n3+blood 0.517293233 0 -0.422222222 serum_choline serum_fattyacid 0.00706 0.226 up up no no no no TMAO+blood Phenylacetic acid+stool 0 0 0.523308271 serum_choline stool_cometabolism 0.00706 0.785 up up no no no no TMAO+blood PUFA/MUFA+blood 0.44962406 0 0 serum_choline serum_fattyacid 0.00706 0.00108 up up no dn no up TMAO+blood PUFA/UFA+blood 0.478195489 0 0 serum_choline serum_fattyacid 0.00706 0.000732 up up no dn no up TMAO+blood PUFA%+blood 0.580451128 0 0 serum_choline serum_fattyacid 0.00706 0.0013 up up no dn no up TMAO+blood Serine+blood 0.642105263 0.568627451 0 serum_choline serum_aminoacids 0.00706 0.942 up up no no no no TMAO+blood Th1 and Th2 cell differentiation 0 0.555882353 0 serum_choline kegg 0.00706 NA up up no no no no TMAO+blood Th17 cell differentiation 0 0.588235294 0 serum_choline kegg 0.00706 NA up up no no no no TMAO+blood Toxoplasmosis 0 0.641176471 0 serum_choline kegg 0.00706 NA up up no no no no TMAO+blood UDCA+stool -0.604395604 0 0 serum_choline stool_bileacids 0.00706 0.266 up up no no no no TNF signaling pathway 2-Oxocarboxylic acid metabolism -0.499130435 -0.469367589 0 kegg kegg NA NA no no no no no no TNF signaling pathway Adherens junction -0.42 -0.600790514 0 kegg kegg NA NA no no no no no no TNF signaling pathway "Alanine, aspartate and glutamate metabolism" 0 0.608695652 0 kegg kegg NA NA no no no no no no TNF signaling pathway Amino sugar and nucleotide sugar metabolism -0.437391304 0 -0.453024453 kegg kegg NA NA no no no no no no TNF signaling pathway Anaerostipes 0 0 -0.441301218 butyrate-producing kegg Genus NA 0.568 no no no no no no TNF signaling pathway Apelin signaling pathway 0 -0.650197628 0 kegg kegg NA NA no no no no no no TNF signaling pathway Apoptosis 0 0.776679842 0 kegg kegg NA NA no no no no no no TNF signaling pathway Arachidonic acid metabolism -0.54 0 0 kegg kegg NA NA no no no no no no TNF signaling pathway Arginine and proline metabolism 0 0.678853755 0.402059202 kegg kegg NA NA no no no no up no TNF signaling pathway Arginine biosynthesis 0 0.583992095 0 kegg kegg NA NA no no no no no no TNF signaling pathway Ascorbate and aldarate metabolism -0.495652174 0 0 kegg kegg NA NA no no no no no no TNF signaling pathway Autophagy - animal 0.626956522 0.839920949 0 kegg kegg NA NA no no no no no no TNF signaling pathway Autophagy - other 0.610434783 0.517786561 0 kegg kegg NA NA no no no no no no TNF signaling pathway Axon guidance 0.497391304 0 0 kegg kegg NA NA no no no no up up TNF signaling pathway B cell receptor signaling pathway 0.442608696 0.914031621 0.792277992 kegg kegg NA NA no no no no no no TNF signaling pathway Basal transcription factors 0 -0.443675889 0 kegg kegg NA NA no no no no no no TNF signaling pathway Base excision repair 0 0 -0.563191763 kegg kegg NA NA no no no no no no TNF signaling pathway beta-Alanine metabolism -0.66 -0.570158103 -0.685714286 kegg kegg NA NA no no no no no no TNF signaling pathway Biosynthesis of cofactors -0.433043478 -0.575098814 0 kegg kegg NA NA no no no no no no TNF signaling pathway Biosynthesis of unsaturated fatty acids -0.663478261 -0.609683794 -0.744401544 kegg kegg NA NA no no no no no no TNF signaling pathway Butanoate metabolism -0.590434783 -0.743083004 -0.687001287 kegg kegg NA NA no no no no no no TNF signaling pathway C-type lectin receptor signaling pathway 0.773043478 0.922924901 0.802574003 kegg kegg NA NA no no no no no no TNF signaling pathway cAMP signaling pathway 0.619130435 0.716403162 0.621364221 yes kegg kegg NA NA no no no no up up TNF signaling pathway Carbon metabolism -0.509565217 0 0 kegg kegg NA NA no no no no no no TNF signaling pathway Cardiac muscle contraction 0 -0.502964427 0 kegg kegg NA NA no no no no no up TNF signaling pathway Cell cycle 0 -0.5 0 kegg kegg NA NA no no no no no no TNF signaling pathway Cellular senescence 0 0.588932806 0.526640927 kegg kegg NA NA no no no no no no TNF signaling pathway cGMP-PKG signaling pathway 0 0.46541502 0 kegg kegg NA NA no no no no no no TNF signaling pathway Chemokine signaling pathway 0.50173913 0.575098814 0.48957529 kegg kegg NA NA no no no no no no TNF signaling pathway Citrate cycle (TCA cycle) -0.64173913 -0.776679842 0 kegg kegg NA NA no no no no no no TNF signaling pathway Cysteine and methionine metabolism 0 -0.785573123 -0.654311454 kegg kegg NA NA no no no no no no TNF signaling pathway Cytosolic DNA-sensing pathway 0.587826087 0.768774704 0.74002574 kegg kegg NA NA no no no no no no TNF signaling pathway DNA replication 0 -0.755928854 0 kegg kegg NA NA no no no no no no TNF signaling pathway Drug metabolism - cytochrome P450 0 -0.813241107 0 kegg kegg NA NA no no no no no no TNF signaling pathway Drug metabolism - other enzymes -0.626086957 -0.748023715 0 kegg kegg NA NA no no no no no no TNF signaling pathway ECM-receptor interaction 0 -0.45256917 0 kegg kegg NA NA no no no no up up TNF signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.483201581 0 kegg kegg NA NA no no no no no no TNF signaling pathway Endocytosis 0 0 0.473616474 kegg kegg NA NA no no no no no no TNF signaling pathway ErbB signaling pathway 0.627826087 0.666007905 0 kegg kegg NA NA no no no no no no TNF signaling pathway Fanconi anemia pathway 0 0 -0.412097812 kegg kegg NA NA no no no no no no TNF signaling pathway Fatty acid biosynthesis 0 0.580039526 0 kegg kegg NA NA no no no no no no TNF signaling pathway Fatty acid elongation -0.776521739 -0.589920949 -0.766537967 kegg kegg NA NA no no no no no no TNF signaling pathway Fatty acid metabolism -0.417391304 0 -0.418275418 kegg kegg NA NA no no no no no no TNF signaling pathway Fc epsilon RI signaling pathway 0 0.773715415 0.437065637 kegg kegg NA NA no no no no no no TNF signaling pathway Focal adhesion -0.428695652 -0.661067194 0 kegg kegg NA NA no no no no up up TNF signaling pathway FoxO signaling pathway 0 0.485177866 -0.418275418 kegg kegg NA NA no no no no no no TNF signaling pathway Fructose and mannose metabolism 0 0.503952569 0 kegg kegg NA NA no no no no no no TNF signaling pathway Glutathione metabolism 0 -0.626482213 0 kegg kegg NA NA no no no no no no TNF signaling pathway Glycerolipid metabolism 0 0.418972332 0 kegg kegg NA NA no no no no no up TNF signaling pathway Glycolysis / Gluconeogenesis -0.522608696 -0.68083004 -0.548777349 kegg kegg NA NA no no no no no no TNF signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.82312253 0.471557272 kegg kegg NA NA no no no no no no TNF signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.492173913 0 0 kegg kegg NA NA no no no no no no TNF signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.567193676 0.458687259 kegg kegg NA NA no no no no no no TNF signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.587944664 0 kegg kegg NA NA no no no no no no TNF signaling pathway Hematopoietic cell lineage -0.515652174 -0.446640316 -0.595109395 kegg kegg NA NA no no no no no no TNF signaling pathway HIF-1 signaling pathway 0 -0.542490119 0 kegg kegg NA NA no no no no no no TNF signaling pathway Hippo signaling pathway -0.522608696 -0.627470356 0 kegg kegg NA NA no no no no no no TNF signaling pathway Hippo signaling pathway - multiple species 0 0.583992095 0 kegg kegg NA NA no no no no no no TNF signaling pathway Histidine metabolism -0.545217391 0 -0.462805663 kegg kegg NA NA no no no no no no TNF signaling pathway Homologous recombination 0 0 -0.510939511 kegg kegg NA NA no no no no no no TNF signaling pathway IL-17 signaling pathway 0 0.458498024 0 kegg kegg NA NA no no no no no no TNF signaling pathway JAK-STAT signaling pathway 0 0.709486166 0 kegg kegg NA NA no no no no no no TNF signaling pathway Lachnospira 0 -0.474425515 0 butyrate-producing kegg Genus NA 0.279 no no no no no no TNF signaling pathway Longevity regulating pathway - multiple species -0.405217391 0 -0.607722008 kegg kegg NA NA no no no no no no TNF signaling pathway Mannose type O-glycan biosynthesis 0.462608696 0 0 kegg kegg NA NA no no no no no no TNF signaling pathway Metabolism of xenobiotics by cytochrome P450 -0.469565217 -0.818181818 -0.402831403 kegg kegg NA NA no no no no no no TNF signaling pathway Mismatch repair -0.575652174 -0.798418972 -0.613899614 kegg kegg NA NA no no no no no no TNF signaling pathway mRNA surveillance pathway 0.425217391 0 0 kegg kegg NA NA no no no no no no TNF signaling pathway mTOR signaling pathway 0 -0.461462451 0 kegg kegg NA NA no no no no no no TNF signaling pathway N-Glycan biosynthesis 0 -0.603754941 0 kegg kegg NA NA no no no no no no TNF signaling pathway Natural killer cell mediated cytotoxicity 0 0.469367589 0.453796654 kegg kegg NA NA no no no no no no TNF signaling pathway NF-kappa B signaling pathway 0.46 0.919960474 0.676447876 kegg kegg NA NA no no no no no no TNF signaling pathway Nicotinate and nicotinamide metabolism 0 0.588932806 0 kegg kegg NA NA no no no no no no TNF signaling pathway Nitrogen metabolism 0 0.566205534 0 kegg kegg NA NA no no no no no no TNF signaling pathway NOD-like receptor signaling pathway 0 0.806324111 0 kegg kegg NA NA no no no no no no TNF signaling pathway Non-homologous end-joining -0.656521739 -0.704545455 -0.6002574 kegg kegg NA NA no no no no no no TNF signaling pathway Notch signaling pathway 0 0.508893281 0 kegg kegg NA NA no no no no no no TNF signaling pathway Nucleotide excision repair 0 -0.749011858 -0.647104247 kegg kegg NA NA no no no no no no TNF signaling pathway One carbon pool by folate -0.446956522 -0.735177866 -0.442471042 kegg kegg NA NA no no no no no no TNF signaling pathway Oocyte meiosis 0 -0.742094862 0 kegg kegg NA NA no no no no no no TNF signaling pathway Osteoclast differentiation 0 0.683794466 0.552123552 kegg kegg NA NA no no no no no no TNF signaling pathway Other glycan degradation 0 0.507905138 0 kegg kegg NA NA no no no no no no TNF signaling pathway Oxidative phosphorylation 0 -0.552371542 0 kegg kegg NA NA no no no no no no TNF signaling pathway Pentose and glucuronate interconversions -0.653043478 -0.684782609 0 kegg kegg NA NA no no no no no no TNF signaling pathway Phenylalanine metabolism -0.690434783 -0.713438735 -0.538223938 kegg kegg NA NA no no no no no no TNF signaling pathway Phospholipase D signaling pathway 0 0.726284585 0.428828829 kegg kegg NA NA no no no no up up TNF signaling pathway Platelet activation -0.456521739 -0.56916996 0 kegg kegg NA NA no no no no no no TNF signaling pathway PPAR signaling pathway 0 0.692687747 0.526640927 kegg kegg NA NA no no no no no no TNF signaling pathway Primary bile acid biosynthesis -0.695652174 -0.683794466 -0.609266409 kegg kegg NA NA no no no no no no TNF signaling pathway Propanoate metabolism -0.413043478 -0.773715415 -0.657915058 kegg kegg NA NA no no no no no no TNF signaling pathway Proteasome 0 -0.690711462 0 kegg kegg NA NA no no no no no no TNF signaling pathway Protein export 0 -0.619565217 0 kegg kegg NA NA no no no no no no TNF signaling pathway Protein processing in endoplasmic reticulum 0 -0.539525692 0 kegg kegg NA NA no no no no no no TNF signaling pathway Pyrimidine metabolism -0.555652174 -0.716403162 0 kegg kegg NA NA no no no no no no TNF signaling pathway Pyruvate metabolism -0.52 -0.805335968 -0.73976834 kegg kegg NA NA no no no no no no TNF signaling pathway Ras signaling pathway 0 -0.586956522 0 yes kegg kegg NA NA no no no no up up TNF signaling pathway Retinol metabolism -0.554782609 -0.658102767 -0.502445302 kegg kegg NA NA no no no no no no TNF signaling pathway Ribosome 0 -0.568181818 0 kegg kegg NA NA no no no no no no TNF signaling pathway Ribosome biogenesis in eukaryotes 0 -0.504940711 0 kegg kegg NA NA no no no no no no TNF signaling pathway RIG-I-like receptor signaling pathway 0.772173913 0.910079051 0.756241956 kegg kegg NA NA no no no no no no TNF signaling pathway RNA degradation 0 -0.458498024 0 kegg kegg NA NA no no no no no no TNF signaling pathway RNA polymerase 0 -0.558300395 0 kegg kegg NA NA no no no no no no TNF signaling pathway Sarcina 0 0.422326513 0 kegg Genus NA 0.0703 no no no no no no TNF signaling pathway Signaling pathways regulating pluripotency of stem cells 0.590434783 0.418972332 0 kegg kegg NA NA no no no no no no TNF signaling pathway SNARE interactions in vesicular transport 0 0.635375494 0 kegg kegg NA NA no no no no no no TNF signaling pathway Sphingolipid signaling pathway 0.515652174 0.568181818 0 kegg kegg NA NA no no no no no no TNF signaling pathway Starch and sucrose metabolism 0 0.458498024 0 kegg kegg NA NA no no no no no no TNF signaling pathway Steroid biosynthesis 0 -0.836956522 -0.616988417 kegg kegg NA NA no no no no no no TNF signaling pathway Steroid hormone biosynthesis -0.65826087 -0.736166008 0 kegg kegg NA NA no no no no no no TNF signaling pathway Sulfur metabolism -0.486086957 -0.445652174 0 kegg kegg NA NA no no no no no no TNF signaling pathway Synthesis and degradation of ketone bodies -0.510434783 -0.734189723 -0.533333333 kegg kegg NA NA no no no no no no TNF signaling pathway T cell receptor signaling pathway 0.597391304 0.683794466 0 kegg kegg NA NA no no no no no no TNF signaling pathway Taurine and hypotaurine metabolism 0 0.571146245 0 kegg kegg NA NA no no no no no no TNF signaling pathway Terpenoid backbone biosynthesis 0 -0.449604743 0 kegg kegg NA NA no no no no no no TNF signaling pathway TGF-beta signaling pathway 0 -0.598814229 0 kegg kegg NA NA no no no no no no TNF signaling pathway Th1 and Th2 cell differentiation 0 0.520750988 0 kegg kegg NA NA no no no no no no TNF signaling pathway Th17 cell differentiation 0 0.583992095 0 kegg kegg NA NA no no no no no no TNF signaling pathway Thiamine metabolism 0 -0.588932806 0 kegg kegg NA NA no no no no no no TNF signaling pathway Tight junction -0.499130435 -0.618577075 -0.435006435 kegg kegg NA NA no no no no no no TNF signaling pathway Toll-like receptor signaling pathway 0.807826087 0.881422925 0.850707851 yes kegg kegg NA NA no no no no no no TNF signaling pathway Tryptophan metabolism -0.722608696 -0.72826087 -0.495495495 kegg kegg NA NA no no no no up no TNF signaling pathway Tyrosine metabolism -0.773043478 -0.860671937 -0.765250965 kegg kegg NA NA no no no no no no TNF signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.666956522 -0.694664032 -0.518146718 kegg kegg NA NA no no no no no no TNF signaling pathway "Valine, leucine and isoleucine degradation" -0.613043478 -0.732213439 -0.714800515 kegg kegg NA NA no no no no no no TNF signaling pathway Various types of N-glycan biosynthesis 0 -0.446640316 0 kegg kegg NA NA no no no no no no TNF signaling pathway Vascular smooth muscle contraction 0 -0.643280632 0 kegg kegg NA NA no no no no no no TNF signaling pathway VEGF signaling pathway 0.554782609 0.674901186 0 kegg kegg NA NA no no no no no no TNF signaling pathway Wnt signaling pathway 0 -0.498023715 0 kegg kegg NA NA no no no no no no TNF-a 14:0+blood -0.745454545 0 0 yes serum_cytokines serum_fattyacid 0.613 0.00572 no no no up no dn TNF-a 16:0/18:0-PS+blood -0.709090909 0 0 serum_cytokines serum_phospholipids 0.613 0.377 no no no no no no TNF-a 16:0+blood -0.648484848 0 0 yes serum_cytokines serum_fattyacid 0.613 0.00876 no no no up no no TNF-a 18:0/18:0-PS+blood -0.854545455 0 0 serum_cytokines serum_phospholipids 0.613 0.00617 no no no no up no TNF-a 18:0/22:6-PA+blood -0.672727273 0 0 serum_cytokines serum_phospholipids 0.613 0.22 no no no no no no TNF-a 18:1-LPC+blood 0.721212121 0 0 serum_cytokines serum_phospholipids 0.613 0.179 no no no no no no TNF-a 20:0+blood 0.696969697 0 0 yes serum_cytokines serum_fattyacid 0.613 0.000278 no no no dn no up TNF-a 20:1+blood 0.76969697 0 0 yes serum_cytokines serum_fattyacid 0.613 2.56E-05 no no no dn dn dn TNF-a B cell receptor signaling pathway 0.60989011 0 0 serum_cytokines kegg 0.613 NA no no no no no no TNF-a Bifidobacterium -0.604395604 0 0 acetate-producing serum_cytokines Genus 0.613 0.105 no no no no dn no TNF-a Biosynthesis of amino acids -0.615384615 0 0 serum_cytokines kegg 0.613 NA no no no no no no TNF-a Carbon metabolism -0.615384615 0 0 serum_cytokines kegg 0.613 NA no no no no no no TNF-a Choline+blood 0.76969697 0 0 serum_cytokines serum_choline 0.613 0.0395 no no no no up no TNF-a Collinsella -0.610729601 0 0 serum_cytokines Genus 0.613 0.128 no no no no no no TNF-a EPA+blood -0.733333333 0 0 serum_cytokines serum_ARA 0.613 0.212 no no no no no no TNF-a Gemmiger -0.56043956 0 0 butyrate-producing serum_cytokines Genus 0.613 0.595 no no no no no no TNF-a Glycolysis / Gluconeogenesis -0.708791209 0 0 serum_cytokines kegg 0.613 NA no no no no no no TNF-a GM-CSF 0 0 -0.508342603 yes serum_cytokines serum_cytokines 0.613 0.0124 no no no up no no TNF-a IFN-g 0 -0.6 0 serum_cytokines serum_cytokines 0.613 0.825 no no no no no no TNF-a IL-17A 0 0 0.562625139 serum_cytokines serum_cytokines 0.613 0.855 no no no no no no TNF-a IL-1ra 0 0 -0.567964405 yes serum_cytokines serum_cytokines 0.613 0.0288 no no no no up no TNF-a IL-2 0 -0.588311688 0 serum_cytokines serum_cytokines 0.613 0.522 no no no no no no TNF-a IL-4 0 0 0.572858732 serum_cytokines serum_cytokines 0.613 0.858 no no no no no no TNF-a IL-6 0 -0.471428571 0 serum_cytokines serum_cytokines 0.613 0.52 no no no no no no TNF-a IL-8 0 0 -0.514571746 serum_cytokines serum_cytokines 0.613 0.579 no no no no no no TNF-a IL-9 0 0.51038961 0 serum_cytokines serum_cytokines 0.613 0.906 no no no no no no TNF-a Insulin resistance 0.56043956 0 0 serum_cytokines kegg 0.613 NA no no no no no no TNF-a IP-10 0 0.588311688 0 serum_cytokines serum_cytokines 0.613 0.394 no no no no no no TNF-a L-Citrulline+blood 0.757575758 0 0 serum_cytokines serum_aminoacids 0.613 0.534 no no no no no no TNF-a L-Homocystine+blood 0.660606061 0 0 serum_cytokines serum_aminoacids 0.613 0.197 no no no no no no TNF-a Longevity regulating pathway - multiple species -0.615384615 0 0 serum_cytokines kegg 0.613 NA no no no no no no TNF-a MIP-1a 0 0.67012987 0 serum_cytokines serum_cytokines 0.613 0.68 no no no no no no TNF-a MIP-1b 0 0.509090909 0 serum_cytokines serum_cytokines 0.613 0.632 no no no no no no TNF-a mRNA surveillance pathway 0.659340659 0 0 serum_cytokines kegg 0.613 NA no no no no no no TNF-a NF-kappa B signaling pathway 0.604395604 0 0 serum_cytokines kegg 0.613 NA no no no no no no TNF-a Pathways in cancer 0.642857143 0 0 serum_cytokines kegg 0.613 NA no no no no no no TNF-a Primary immunodeficiency -0.587912088 0 0 serum_cytokines kegg 0.613 NA no no no no no no TNF-a RNA degradation 0.593406593 0 0 serum_cytokines kegg 0.613 NA no no no no no no TNF-a Roseburia -0.675824176 0 0 butyrate-producing serum_cytokines Genus 0.613 0.495 no no no no no no TNF-a Small cell lung cancer 0.82967033 0 0 serum_cytokines kegg 0.613 NA no no no no no up TNF-a Th1 and Th2 cell differentiation 0.736263736 0 0 serum_cytokines kegg 0.613 NA no no no no no no TNF-a Th17 cell differentiation 0.747252747 0 0 serum_cytokines kegg 0.613 NA no no no no no no TNF-a TXB2+blood -0.790277207 0 0 yes serum_cytokines serum_ARA 0.613 0.0644 no no no dn no no ToFA+blood 12-ketoDCA+blood -0.453868406 0 0 serum_fattyacid serum_bileacids 0.0307 0.517 up no dn no no no ToFA+blood 14:0/16:0-PC+blood 0 0 0.484444444 serum_fattyacid serum_phospholipids 0.0307 0.0358 up no dn no up no ToFA+blood 14:0/18:0-PC+blood 0 0 0.463247863 serum_fattyacid serum_phospholipids 0.0307 0.00289 up no dn up up no ToFA+blood 14:0/18:2-PC+blood 0 0 0.40991453 serum_fattyacid serum_phospholipids 0.0307 0.102 up no dn no up no ToFA+blood 14:0+blood 0.693233083 0 0.642393162 yes serum_fattyacid serum_fattyacid 0.0307 0.00572 up no dn up no dn ToFA+blood 16:0/16:1-PC+blood 0 0 0.499487179 serum_fattyacid serum_phospholipids 0.0307 0.00283 up no dn up up no ToFA+blood 16:0/18:1-PC+blood 0 0 0.494700855 serum_fattyacid serum_phospholipids 0.0307 6.15E-07 up no dn up up up ToFA+blood 16:0+blood 0.939849624 0.894607843 0.895384615 yes serum_fattyacid serum_fattyacid 0.0307 0.00876 up no dn up no no ToFA+blood 16:1-LPC+blood 0 0 0.491282051 serum_fattyacid serum_phospholipids 0.0307 0.0241 up no dn no up no ToFA+blood 16:1+blood 0.727819549 0 0.554871795 yes serum_fattyacid serum_fattyacid 0.0307 0.0186 up no dn no no dn ToFA+blood 18:0/16:0-PC+blood 0 0 0.45025641 serum_fattyacid serum_phospholipids 0.0307 9.64E-07 up no dn up up up ToFA+blood 18:0/20:4-PI+blood 0 0.56372549 0 serum_fattyacid serum_phospholipids 0.0307 0.167 up no dn no no no ToFA+blood 18:0+blood 0.793984962 0.691176471 0.581538462 serum_fattyacid serum_fattyacid 0.0307 0.344 up no dn no no no ToFA+blood 18:1-LPE+blood 0 0 -0.407863248 serum_fattyacid serum_phospholipids 0.0307 0.117 up no dn no no no ToFA+blood 18:1/18:0-PS+blood 0 0.632352941 0 serum_fattyacid serum_phospholipids 0.0307 0.193 up no dn no no no ToFA+blood 18:1+blood 0.82406015 0.674019608 0.645128205 yes serum_fattyacid serum_fattyacid 0.0307 0.00202 up no dn up no dn ToFA+blood 18:2-LPC+blood 0 0 -0.454358974 serum_fattyacid serum_phospholipids 0.0307 0.00743 up no dn dn no up ToFA+blood 18:2n6c+blood 0.660150376 0.715686275 0.71008547 serum_fattyacid serum_fattyacid 0.0307 0.15 up no dn no no no ToFA+blood 18:3n3+blood 0.581954887 0 0 serum_fattyacid serum_fattyacid 0.0307 0.291 up no dn no no no ToFA+blood 20:2/18:3-PE+blood 0 0.610294118 0 serum_fattyacid serum_phospholipids 0.0307 0.0391 up no dn up up no ToFA+blood 20:3/16:0-PC+blood 0 0.507352941 0 serum_fattyacid serum_phospholipids 0.0307 0.00405 up no dn no up up ToFA+blood 20:3/18:0-PC+blood 0.448120301 0 0 serum_fattyacid serum_phospholipids 0.0307 0.296 up no dn no no no ToFA+blood 20:3/18:0-PI+blood 0 0.49754902 0 serum_fattyacid serum_phospholipids 0.0307 0.289 up no dn no no no ToFA+blood 20:3n6+blood 0 0 0.563076923 serum_fattyacid serum_fattyacid 0.0307 0.0884 up no dn up no no ToFA+blood 20:4-LPA+blood 0.457142857 0 0 serum_fattyacid serum_phospholipids 0.0307 0.398 up no dn no no no ToFA+blood 20:4-LPE+blood 0 0.558823529 0 serum_fattyacid serum_phospholipids 0.0307 0.552 up no dn no no no ToFA+blood 20:4/18:0-PE+blood 0 0.522058824 0 serum_fattyacid serum_phospholipids 0.0307 0.000755 up no dn up up no ToFA+blood 20:4n6+blood 0 0.595588235 0 serum_fattyacid serum_fattyacid 0.0307 0.133 up no dn no no no ToFA+blood 22:6n3+blood 0.536842105 0 0 serum_fattyacid serum_fattyacid 0.0307 0.792 up no dn no no no ToFA+blood 24:0+blood 0 0.512254902 0 serum_fattyacid serum_fattyacid 0.0307 0.034 up no dn dn no up ToFA+blood 24:1+blood 0 0.56372549 0 serum_fattyacid serum_fattyacid 0.0307 0.00582 up no dn no dn dn ToFA+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0.626373626 0 0 serum_fattyacid stool_cometabolism 0.0307 0.33 up no dn no no no ToFA+blood AA+blood 0.494736842 0 0 serum_fattyacid serum_ARA 0.0307 0.212 up no dn no no no ToFA+blood AGE-RAGE signaling pathway in diabetic complications 0.568421053 0 0 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood Arginine and proline metabolism 0 0 0.496153846 serum_fattyacid kegg 0.0307 NA up no dn no up no ToFA+blood Arrhythmogenic right ventricular cardiomyopathy 0 0 -0.400769231 serum_fattyacid kegg 0.0307 NA up no dn no up up ToFA+blood Bifidobacterium 0 -0.62660956 0 acetate-producing serum_fattyacid Genus 0.0307 0.105 up no dn no dn no ToFA+blood Biosynthesis of cofactors 0 0 0.483846154 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood Cardiac muscle contraction 0 0 -0.408461538 serum_fattyacid kegg 0.0307 NA up no dn no no up ToFA+blood Central carbon metabolism in cancer 0.524561404 0 0 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood Cytokine-cytokine receptor interaction 0.459649123 0 0 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood DCA+blood -0.467669173 0 0 serum_fattyacid serum_bileacids 0.0307 0.122 up no dn no no no ToFA+blood Focal adhesion 0 0 -0.484615385 serum_fattyacid kegg 0.0307 NA up no dn no up up ToFA+blood FoxO signaling pathway 0 0 -0.445384615 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood GCDCA+blood 0 0 -0.489230769 serum_fattyacid serum_bileacids 0.0307 0.31 up no dn no no no ToFA+blood GLCA+blood 0 -0.560112034 -0.458913615 serum_fattyacid serum_bileacids 0.0307 0.319 up no dn no no no ToFA+blood Glioma 0.498245614 0 0 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood Glutathione metabolism 0 0 0.421538462 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood "Glycine, serine and threonine metabolism" 0 -0.641176471 0.445384615 serum_fattyacid kegg 0.0307 NA up no dn no up no ToFA+blood HCA+blood 0 0 -0.414638714 serum_fattyacid serum_bileacids 0.0307 0.544 up no dn no no no ToFA+blood Hippo signaling pathway 0 0 -0.47 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood isovaleric acid iso-C5+blood 0 0.519607843 0 serum_fattyacid serum_scfa 0.0307 0.117 up no dn no no no ToFA+blood Kaposi sarcoma-associated herpesvirus infection -0.475438596 0 0 serum_fattyacid kegg 0.0307 NA up no dn no no dn ToFA+blood L-Proline+blood -0.485714286 0 -0.513162393 yes serum_fattyacid serum_aminoacids 0.0307 0.00265 up no dn up up no ToFA+blood Lipid and atherosclerosis 0.570175439 0 0 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood MUFA+blood 0.82556391 0.693627451 0.654700855 serum_fattyacid serum_fattyacid 0.0307 0.00175 up no dn up no dn ToFA+blood n6+blood 0.872180451 0.916666667 0.881025641 serum_fattyacid serum_fattyacid 0.0307 0.153 up no dn no no no ToFA+blood NOD-like receptor signaling pathway 0.475438596 0 0 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood Odoribacter 0 0 -0.40420076 butyrate-producing serum_fattyacid Genus 0.0307 0.798 up no dn no no no ToFA+blood Pathways of neurodegeneration - multiple diseases -0.463157895 0 0 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood Pertussis 0.556140351 0 0 serum_fattyacid kegg 0.0307 NA up no dn no no dn ToFA+blood Porphyrin and chlorophyll metabolism 0 -0.644117647 0.483076923 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood Prevotella 0 0.502855623 0 acetate-producing serum_fattyacid Genus 0.0307 0.287 up no dn no no no ToFA+blood PUFA/MUFA+blood -0.466165414 0 0 serum_fattyacid serum_fattyacid 0.0307 0.00108 up no dn dn no up ToFA+blood PUFA+blood 0.962406015 0.950980392 0.872136752 serum_fattyacid serum_fattyacid 0.0307 0.212 up no dn no no no ToFA+blood Ruminococcus 0 -0.50245098 0 acetate-producing serum_fattyacid Genus 0.0307 0.335 up no dn no no no ToFA+blood Salivary secretion 0 0.511764706 0 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood SFA+blood 0.945864662 0.946078431 0.937777778 serum_fattyacid serum_fattyacid 0.0307 0.0386 up no dn up no no ToFA+blood Shigellosis -0.61754386 0 0 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood Sphingolipid signaling pathway 0 0 -0.534615385 serum_fattyacid kegg 0.0307 NA up no dn no no no ToFA+blood T-a-MCA+blood 0 0 0.453985683 serum_fattyacid serum_bileacids 0.0307 0.478 up no dn no no no ToFA+blood Ubiquitin mediated proteolysis -0.473684211 0 0 serum_fattyacid kegg 0.0307 NA up no dn no no no Toll-like receptor signaling pathway 2-Oxocarboxylic acid metabolism -0.410434783 -0.651185771 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Adherens junction 0 -0.533596838 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Adrenergic signaling in cardiomyocytes 0 -0.572134387 0 yes kegg kegg NA NA no no no no no up Toll-like receptor signaling pathway "Alanine, aspartate and glutamate metabolism" 0.436521739 0.780632411 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway alpha-Linolenic acid metabolism 0 0.434782609 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Amino sugar and nucleotide sugar metabolism 0 0 -0.483912484 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Aminoacyl-tRNA biosynthesis 0 -0.564229249 -0.555212355 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Antifolate resistance 0 -0.540513834 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Apelin signaling pathway 0 -0.684782609 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Apoptosis 0 0.890316206 0.562162162 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Apoptosis - multiple species 0 0 -0.569111969 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Arachidonic acid metabolism -0.53826087 0 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Arginine and proline metabolism 0 0.831027668 0.495495495 yes kegg kegg NA NA no no no no up no Toll-like receptor signaling pathway Arginine biosynthesis 0.405217391 0.780632411 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Ascorbate and aldarate metabolism 0 -0.443675889 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Autophagy - animal 0.682608696 0.807312253 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Autophagy - other 0.430434783 0 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Basal transcription factors 0 -0.637351779 -0.562419562 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Base excision repair 0 -0.557312253 -0.77039897 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway beta-Alanine metabolism 0 0 -0.553153153 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Biosynthesis of amino acids 0 0.668972332 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Biosynthesis of cofactors -0.648695652 -0.675889328 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Biosynthesis of unsaturated fatty acids -0.454782609 -0.422924901 -0.595624196 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Butanoate metabolism -0.528695652 -0.785573123 -0.686743887 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway cAMP signaling pathway 0 0.624505929 0.541055341 yes yes kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway Cardiac muscle contraction 0 -0.615612648 0 yes kegg kegg NA NA no no no no no up Toll-like receptor signaling pathway Cell adhesion molecules 0 0.535573123 0.463835264 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Cell cycle 0 -0.772727273 -0.517631918 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Cellular senescence 0 0.659090909 0.601029601 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway cGMP-PKG signaling pathway 0.453913043 0.769762846 0.567824968 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Chemokine signaling pathway 0.625217391 0.731225296 0.684427284 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Citrate cycle (TCA cycle) -0.6 -0.801383399 -0.45971686 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Clostridium -0.404870634 0 0 yes kegg Genus NA 0.925 no no no no no no Toll-like receptor signaling pathway Complement and coagulation cascades 0 0.623517787 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Cysteine and methionine metabolism -0.447826087 -0.760869565 -0.741827542 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway DNA replication -0.430434783 -0.886363636 -0.611068211 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Drug metabolism - cytochrome P450 0 -0.84486166 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Drug metabolism - other enzymes -0.459130435 -0.776679842 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway ECM-receptor interaction 0 -0.513833992 0 yes kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway EGFR tyrosine kinase inhibitor resistance 0 -0.528656126 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Endocytosis 0 0.563241107 0.622393822 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway ErbB signaling pathway 0.533043478 0.448616601 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Ether lipid metabolism 0 -0.599802372 -0.549034749 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Fanconi anemia pathway 0 -0.517786561 -0.672844273 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Fatty acid biosynthesis 0.432173913 0.782608696 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Fatty acid degradation 0 0.501976285 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Fatty acid elongation -0.451304348 0 -0.56036036 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Fatty acid metabolism 0 0.447628458 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Focal adhesion 0 -0.558300395 0 yes kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway Folate biosynthesis 0 -0.468379447 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway FoxO signaling pathway 0 0.429841897 -0.478249678 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Fructose and mannose metabolism 0 0.425889328 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Galactose metabolism 0 0.455533597 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Glutathione metabolism -0.504347826 -0.671936759 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway "Glycine, serine and threonine metabolism" -0.569565217 -0.497035573 0 yes kegg kegg NA NA no no no no up no Toll-like receptor signaling pathway Glycolysis / Gluconeogenesis 0 -0.523715415 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.594782609 0.755928854 0.454311454 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.474782609 -0.510869565 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Glycosaminoglycan degradation 0 0.467391304 0 yes kegg kegg NA NA no no no no no up Toll-like receptor signaling pathway Glycosphingolipid biosynthesis - ganglio series -0.427826087 -0.563241107 -0.46975547 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.806324111 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Hedgehog signaling pathway 0 -0.542490119 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway HIF-1 signaling pathway 0 -0.5 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Hippo signaling pathway -0.531304348 -0.644268775 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Hippo signaling pathway - multiple species 0 0.638339921 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Homologous recombination 0 0 -0.742857143 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Inositol phosphate metabolism 0 0 -0.43011583 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Linoleic acid metabolism 0 -0.433794466 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Longevity regulating pathway - multiple species 0 0 -0.431402831 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Lysosome 0 0.599802372 0.473616474 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Metabolism of xenobiotics by cytochrome P450 0 -0.801383399 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Mismatch repair -0.496521739 -0.793478261 -0.712483912 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway mRNA surveillance pathway 0 -0.611660079 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway mTOR signaling pathway 0 -0.509881423 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway N-Glycan biosynthesis -0.424347826 -0.836956522 -0.474388674 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Neuroactive ligand-receptor interaction 0 0.479249012 0.43037323 yes kegg kegg NA NA no no no up up up Toll-like receptor signaling pathway Neutrophil extracellular trap formation 0 0.596837945 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway NF-kappa B signaling pathway 0.525217391 0.860671937 0.577606178 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Nicotinate and nicotinamide metabolism 0 0.815217391 0.517374517 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Nitrogen metabolism 0.470434783 0.741106719 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Non-homologous end-joining -0.475652174 -0.52173913 -0.517631918 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Nucleotide excision repair -0.475652174 -0.856719368 -0.836293436 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway One carbon pool by folate -0.539130435 -0.860671937 -0.65971686 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Oocyte meiosis 0 -0.698616601 -0.427284427 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Osteoclast differentiation 0.517391304 0.87944664 0.796138996 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Other types of O-glycan biosynthesis 0 0 -0.464864865 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Oxidative phosphorylation 0 -0.637351779 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway p53 signaling pathway 0 0 -0.554182754 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Pantothenate and CoA biosynthesis 0 0.678853755 0 yes kegg kegg NA NA no no no no no dn Toll-like receptor signaling pathway Pentose and glucuronate interconversions -0.66173913 -0.830039526 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Pentose phosphate pathway 0 0.638339921 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Peroxisome 0 0.601778656 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Phagosome 0 0.559288538 0.505534106 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Phenylalanine metabolism -0.632173913 -0.712450593 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Phosphatidylinositol signaling system 0 -0.497035573 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Phospholipase D signaling pathway 0.506086957 0.698616601 0.481338481 yes kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway PI3K-Akt signaling pathway 0 0 -0.43989704 yes yes kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway Platelet activation 0 -0.455533597 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Platinum drug resistance 0 0 -0.594079794 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Porphyrin and chlorophyll metabolism -0.472173913 -0.442687747 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway PPAR signaling pathway 0.513913043 0.85770751 0.808236808 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Primary bile acid biosynthesis -0.57826087 -0.48715415 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Propanoate metabolism 0 -0.703557312 -0.696525097 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Proteasome 0 -0.611660079 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Protein export 0 -0.708498024 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Protein processing in endoplasmic reticulum -0.411304348 -0.795454545 -0.414157014 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Purine metabolism 0 -0.499011858 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Pyrimidine metabolism 0 -0.836956522 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Pyruvate metabolism -0.5 -0.807312253 -0.774259974 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Ras signaling pathway 0 -0.764822134 0 yes yes kegg kegg NA NA no no no no up up Toll-like receptor signaling pathway Renin-angiotensin system 0 0.673913043 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Retinol metabolism 0 -0.690711462 -0.605405405 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Ribosome 0 -0.597826087 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Ribosome biogenesis in eukaryotes 0 -0.727272727 -0.578378378 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway RNA degradation 0 -0.727272727 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway RNA polymerase 0 -0.798418972 -0.597425997 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway RNA transport 0 -0.449604743 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Sarcina 0 0.444554224 0 yes kegg Genus NA 0.0703 no no no no no no Toll-like receptor signaling pathway Selenocompound metabolism 0 0 -0.591248391 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway SNARE interactions in vesicular transport 0 0.489130435 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Sphingolipid signaling pathway 0.547826087 0.621541502 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Spliceosome 0 0 -0.402831403 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Starch and sucrose metabolism 0 0.664031621 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Steroid biosynthesis -0.473913043 -0.739130435 -0.727927928 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Steroid hormone biosynthesis -0.439130435 -0.660079051 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Sulfur metabolism -0.503478261 -0.420948617 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Synthesis and degradation of ketone bodies -0.514782609 -0.785573123 -0.661003861 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Terpenoid backbone biosynthesis 0 -0.513833992 -0.414671815 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway TGF-beta signaling pathway 0 -0.677865613 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Thiamine metabolism 0 -0.57312253 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Tight junction -0.462608696 -0.449604743 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Tryptophan metabolism -0.557391304 -0.602766798 -0.484427284 yes kegg kegg NA NA no no no no up no Toll-like receptor signaling pathway Tyrosine metabolism -0.615652174 -0.822134387 -0.691377091 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.655652174 -0.73715415 -0.694980695 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Ubiquitin mediated proteolysis 0 -0.514822134 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway "Valine, leucine and isoleucine degradation" -0.587826087 -0.785573123 -0.717631918 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Various types of N-glycan biosynthesis 0 -0.695652174 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Vascular smooth muscle contraction 0 -0.635375494 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway VEGF signaling pathway 0.562608696 0.608695652 0 yes kegg kegg NA NA no no no no no no Toll-like receptor signaling pathway Wnt signaling pathway 0 -0.799407115 0 yes kegg kegg NA NA no no no no no no total_blood_mcfa+blood 14:0/16:0-PC+blood -0.463157895 0 -0.42017094 serum_mcfa serum_phospholipids 8.76E-11 0.0358 dn dn dn no up no total_blood_mcfa+blood 14:0/18:0-PC+blood 0 0 -0.422905983 serum_mcfa serum_phospholipids 8.76E-11 0.00289 dn dn dn up up no total_blood_mcfa+blood 16:0/16:1-PC+blood 0 0 -0.452307692 serum_mcfa serum_phospholipids 8.76E-11 0.00283 dn dn dn up up no total_blood_mcfa+blood 16:0/16:1-PI+blood 0 0 -0.543247863 serum_mcfa serum_phospholipids 8.76E-11 0.262 dn dn dn no no no total_blood_mcfa+blood 16:0/18:2-PI+blood 0 0 -0.442735043 serum_mcfa serum_phospholipids 8.76E-11 0.269 dn dn dn no no no total_blood_mcfa+blood 16:0/18:3-PC+blood -0.502255639 0 -0.517948718 serum_mcfa serum_phospholipids 8.76E-11 0.00216 dn dn dn no up up total_blood_mcfa+blood 16:0/20:3-PC+blood 0 0.593137255 0 serum_mcfa serum_phospholipids 8.76E-11 5.43E-06 dn dn dn no up up total_blood_mcfa+blood 16:0/20:4-PI+blood 0 0 -0.47965812 serum_mcfa serum_phospholipids 8.76E-11 0.558 dn dn dn no no no total_blood_mcfa+blood 16:0/22:6-PE+blood 0 -0.507352941 0 serum_mcfa serum_phospholipids 8.76E-11 0.000934 dn dn dn up up no total_blood_mcfa+blood 18:0-LPE+blood 0 0 -0.452991453 serum_mcfa serum_phospholipids 8.76E-11 0.491 dn dn dn no no no total_blood_mcfa+blood 18:0/22:6-PE+blood 0 -0.568627451 0 serum_mcfa serum_phospholipids 8.76E-11 0.00022 dn dn dn up up no total_blood_mcfa+blood 18:0+blood 0 0 -0.484444444 serum_mcfa serum_fattyacid 8.76E-11 0.344 dn dn dn no no no total_blood_mcfa+blood 18:1/16:0-PE+blood -0.50075188 0 0 serum_mcfa serum_phospholipids 8.76E-11 0.000182 dn dn dn up up no total_blood_mcfa+blood 18:1/18:1-PC+blood 0 0.580882353 0 serum_mcfa serum_phospholipids 8.76E-11 1.34E-05 dn dn dn no up up total_blood_mcfa+blood 18:1/20:3-PC+blood 0 0.595588235 0 serum_mcfa serum_phospholipids 8.76E-11 0.00872 dn dn dn no up up total_blood_mcfa+blood 18:1/20:4-PE+blood 0 -0.519607843 0 serum_mcfa serum_phospholipids 8.76E-11 0.0578 dn dn dn up no no total_blood_mcfa+blood 18:1/20:4-PI+blood 0 0 -0.505641026 serum_mcfa serum_phospholipids 8.76E-11 0.192 dn dn dn no no no total_blood_mcfa+blood 18:2-LPC+blood 0.521804511 0 0 serum_mcfa serum_phospholipids 8.76E-11 0.00743 dn dn dn dn no up total_blood_mcfa+blood 18:2-LPE+blood 0 0.62745098 0 serum_mcfa serum_phospholipids 8.76E-11 0.112 dn dn dn no no no total_blood_mcfa+blood 18:3/16:0-PE+blood -0.673684211 0 -0.422905983 serum_mcfa serum_phospholipids 8.76E-11 0.00149 dn dn dn up up no total_blood_mcfa+blood 18:3n6+blood 0 0 -0.591111111 serum_mcfa serum_fattyacid 8.76E-11 0.0463 dn dn dn up no dn total_blood_mcfa+blood 2-methyl-butyric acid m-C4+blood 0.621052632 0 0 serum_mcfa serum_scfa 8.76E-11 0.262 dn dn dn no no no total_blood_mcfa+blood 20:2/18:0-PC+blood 0 0 -0.401709402 serum_mcfa serum_phospholipids 8.76E-11 0.0427 dn dn dn no up no total_blood_mcfa+blood 20:2+blood 0 0.617647059 0 serum_mcfa serum_fattyacid 8.76E-11 0.478 dn dn dn no no no total_blood_mcfa+blood 20:3-LPE+blood 0 0.600490196 0 serum_mcfa serum_phospholipids 8.76E-11 0.084 dn dn dn no up no total_blood_mcfa+blood 20:5-LPC+blood 0 -0.654411765 0 serum_mcfa serum_phospholipids 8.76E-11 0.558 dn dn dn no no no total_blood_mcfa+blood 22:1-LPA+blood 0 0.541666667 0 serum_mcfa serum_phospholipids 8.76E-11 0.00373 dn dn dn no up up total_blood_mcfa+blood 22:2-LPA+blood 0 0.588235294 0 serum_mcfa serum_phospholipids 8.76E-11 0.0443 dn dn dn dn no no total_blood_mcfa+blood 22:6-LPC+blood 0 -0.549019608 0 serum_mcfa serum_phospholipids 8.76E-11 0.127 dn dn dn no no up total_blood_mcfa+blood 24:0+blood 0 0 -0.401025641 serum_mcfa serum_fattyacid 8.76E-11 0.034 dn dn dn dn no up total_blood_mcfa+blood 9-HODE+blood 0 0 -0.401709402 serum_mcfa serum_ARA 8.76E-11 0.297 dn dn dn no no no total_blood_mcfa+blood acetic acid C2+blood 0.458646617 0 0 serum_mcfa serum_scfa 8.76E-11 0.000193 dn dn dn up dn no total_blood_mcfa+blood capric acid C6+blood 0 0 0.515213675 serum_mcfa serum_scfa 8.76E-11 0.433 dn dn dn no no no total_blood_mcfa+blood Creatinine+blood 0.493233083 0 0 serum_mcfa serum_choline 8.76E-11 0.437 dn dn dn no no no total_blood_mcfa+blood Cysteine+blood 0 0.600490196 0 yes serum_mcfa serum_aminoacids 8.76E-11 1.81E-07 dn dn dn dn up up total_blood_mcfa+blood d18:1-14:1-SM+blood -0.466165414 0 0 serum_mcfa serum_phospholipids 8.76E-11 0.0952 dn dn dn no dn no total_blood_mcfa+blood d18:1-20:0-SM+blood -0.467669173 0 0 serum_mcfa serum_phospholipids 8.76E-11 0.933 dn dn dn no no no total_blood_mcfa+blood decanoic acid C10+blood 0.957894737 0.654411765 0.714188034 serum_mcfa serum_mcfa 8.76E-11 6.64E-11 dn dn dn dn dn no total_blood_mcfa+blood HDCA+blood 0 0 0.548008999 serum_mcfa serum_bileacids 8.76E-11 0.483 dn dn dn no no no total_blood_mcfa+blood heptanoic acid C7+blood 0.82556391 0.833333333 0.447521368 serum_mcfa serum_mcfa 8.76E-11 8.27E-11 dn dn dn dn dn no total_blood_mcfa+blood isobutyric acid C4+blood 0.571428571 0 0 serum_mcfa serum_scfa 8.76E-11 0.0151 dn dn dn up up no total_blood_mcfa+blood L-Alanine+blood 0 0 -0.558974359 yes serum_mcfa serum_aminoacids 8.76E-11 0.00138 dn dn dn up up no total_blood_mcfa+blood L-Asparagine+blood 0.482706767 0 0 serum_mcfa serum_aminoacids 8.76E-11 0.784 dn dn dn no no no total_blood_mcfa+blood L-Lysine+blood 0.476691729 0.504901961 0 yes serum_mcfa serum_aminoacids 8.76E-11 0.0107 dn dn dn no up no total_blood_mcfa+blood L-Tryptophan+blood 0 0 0.42017094 serum_mcfa serum_aminoacids 8.76E-11 0.164 dn dn dn no no no total_blood_mcfa+blood lauric acid C12+blood 0.82406015 0.987745098 0.949401709 serum_mcfa serum_mcfa 8.76E-11 0.015 dn dn dn no dn dn total_blood_mcfa+blood n6/n3+blood 0 0.656862745 0 serum_mcfa serum_fattyacid 8.76E-11 0.226 dn dn dn no no no total_blood_mcfa+blood nonanoic acid C9+blood 0.926315789 0.941176471 0.808547009 serum_mcfa serum_mcfa 8.76E-11 6.51E-11 dn dn dn dn dn no total_blood_mcfa+blood octanoic acid C8+blood 0.864661654 0.757352941 0.464615385 serum_mcfa serum_mcfa 8.76E-11 2.84E-11 dn dn dn dn dn dn total_blood_mcfa+blood propionic acid C3+blood 0.606015038 0 0 serum_mcfa serum_scfa 8.76E-11 0.104 dn dn dn no dn no total_blood_mcfa+blood Sarcosine+blood 0 0 -0.428376068 serum_mcfa serum_choline 8.76E-11 5.06E-05 dn dn dn up up no total_blood_mcfa+blood TMAO+blood 0 0 0.463931624 serum_mcfa serum_choline 8.76E-11 0.00706 dn dn dn up up no total_blood_scfa+blood 14:0-LPC+blood 0 0 -0.40991453 serum_scfa serum_phospholipids 0.168 0.00689 no no no up up no total_blood_scfa+blood 16:0-LPC+blood 0 0 -0.437264957 serum_scfa serum_phospholipids 0.168 0.00456 no no no up up no total_blood_scfa+blood 16:0-LPE+blood 0 0 -0.435213675 serum_scfa serum_phospholipids 0.168 0.0711 no no no up up no total_blood_scfa+blood 16:0/16:0-PI+blood 0 0 -0.50974359 serum_scfa serum_phospholipids 0.168 0.358 no no no no no no total_blood_scfa+blood 16:0/16:1-PI+blood 0 0 -0.563760684 serum_scfa serum_phospholipids 0.168 0.262 no no no no no no total_blood_scfa+blood 16:0/18:2-PI+blood 0 0 -0.556239316 serum_scfa serum_phospholipids 0.168 0.269 no no no no no no total_blood_scfa+blood 16:0/20:4-PI+blood 0 0 -0.51042735 serum_scfa serum_phospholipids 0.168 0.558 no no no no no no total_blood_scfa+blood 18:0-LPA+blood 0 0.585784314 0 serum_scfa serum_phospholipids 0.168 0.0725 no no no no dn no total_blood_scfa+blood 18:0/18:2-PI+blood 0 0 -0.468034188 serum_scfa serum_phospholipids 0.168 0.179 no no no no no no total_blood_scfa+blood 18:0/22:6-PI+blood 0 0.504901961 0 serum_scfa serum_phospholipids 0.168 0.425 no no no no no no total_blood_scfa+blood 18:1-LPC+blood 0.460150376 0 0 serum_scfa serum_phospholipids 0.168 0.179 no no no no no no total_blood_scfa+blood 18:1-LPE+blood 0 0 -0.431794872 serum_scfa serum_phospholipids 0.168 0.117 no no no no no no total_blood_scfa+blood 18:1/16:0-PI+blood 0 0.5 0 serum_scfa serum_phospholipids 0.168 0.793 no no no no no no total_blood_scfa+blood 18:1/18:0-PI+blood 0 0 -0.432478632 serum_scfa serum_phospholipids 0.168 0.0931 no no no no no up total_blood_scfa+blood 18:2-LPE+blood 0 0 -0.487863248 serum_scfa serum_phospholipids 0.168 0.112 no no no no no no total_blood_scfa+blood 18:3n6+blood 0 0 -0.453675214 serum_scfa serum_fattyacid 0.168 0.0463 no no no up no dn total_blood_scfa+blood 20:0+blood 0 0 -0.716239316 yes serum_scfa serum_fattyacid 0.168 0.000278 no no no dn no up total_blood_scfa+blood 20:1-LPA+blood -0.460150376 0.509803922 0 serum_scfa serum_phospholipids 0.168 0.0187 no no no dn dn no total_blood_scfa+blood 20:1-LPC+blood 0.607518797 0 0 serum_scfa serum_phospholipids 0.168 0.217 no no no no no no total_blood_scfa+blood 20:1-LPE+blood 0.622556391 0 0 serum_scfa serum_phospholipids 0.168 0.465 no no no no no no total_blood_scfa+blood 20:2-LPE+blood 0.621052632 0 0 serum_scfa serum_phospholipids 0.168 0.177 no no no no no no total_blood_scfa+blood acetic acid C2+blood 0 0 0.669059829 serum_scfa serum_scfa 0.168 0.000193 no no no up dn no total_blood_scfa+blood CA+blood 0 -0.568976195 0 serum_scfa serum_bileacids 0.168 0.606 no no no no no no total_blood_scfa+blood capric acid C6+blood 0.833082707 0.806372549 0.909059829 serum_scfa serum_scfa 0.168 0.433 no no no no no no total_blood_scfa+blood decanoic acid C10+blood 0 0 0.461196581 serum_scfa serum_mcfa 0.168 6.64E-11 no no no dn dn no total_blood_scfa+blood GCA+blood 0 -0.517156863 0 yes serum_scfa serum_bileacids 0.168 0.16 no no no no no no total_blood_scfa+blood GCDCA+blood 0 -0.517156863 0 serum_scfa serum_bileacids 0.168 0.31 no no no no no no total_blood_scfa+blood HCA+blood 0 -0.547407623 0 serum_scfa serum_bileacids 0.168 0.544 no no no no no no total_blood_scfa+blood isocapric acid iso-C6+blood 0 0.50245098 0 serum_scfa serum_scfa 0.168 0.0458 no no no no no dn total_blood_scfa+blood L-Alanine+blood 0 -0.50245098 -0.656752137 yes serum_scfa serum_aminoacids 0.168 0.00138 no no no up up no total_blood_scfa+blood Sarcosine+blood 0 0 -0.579487179 serum_scfa serum_choline 0.168 5.06E-05 no no no up up no total_blood_scfa+blood TDCA+blood 0 -0.493931731 0 yes serum_scfa serum_bileacids 0.168 0.155 no no no no up no total_stool_scfa+stool 5-Hydroxytryptamine+stool 0 0 -0.415019763 stool_scfa stool_cometabolism 0.0534 0.00862 dn no up dn dn no total_stool_scfa+stool Acetic acid+stool 0.907120743 0.818181818 0.908102767 yes stool_scfa stool_scfa 0.0534 0.0656 dn no up dn no no total_stool_scfa+stool Adrenergic signaling in cardiomyocytes 0 0.618181818 0 stool_scfa kegg 0.0534 NA dn no up no no up total_stool_scfa+stool Akkermansia -0.534529496 0 0 acetate-producing stool_scfa Genus 0.0534 0.23 dn no up no no no total_stool_scfa+stool Alcoholism 0 0 -0.45567476 stool_scfa kegg 0.0534 NA dn no up no no no total_stool_scfa+stool Amoebiasis -0.473684211 0 0 stool_scfa kegg 0.0534 NA dn no up no no no total_stool_scfa+stool AMPK signaling pathway 0.494324045 0 0 stool_scfa kegg 0.0534 NA dn no up no no no total_stool_scfa+stool Apelin signaling pathway 0.562435501 0 0 stool_scfa kegg 0.0534 NA dn no up no no no total_stool_scfa+stool Bacteroides -0.479876161 0 0 LPS-producing stool_scfa Genus 0.0534 0.000267 dn no up dn dn up total_stool_scfa+stool Butyric acid+stool 0.805985552 0.664335664 0.881422925 yes stool_scfa stool_scfa 0.0534 0.102 dn no up dn no no total_stool_scfa+stool Butyricicoccus 0 0 0.478686764 butyrate-producing stool_scfa Genus 0.0534 0.852 dn no up no no no total_stool_scfa+stool CA+stool -0.618163055 0 0 stool_scfa stool_bileacids 0.0534 0.827 dn no up no no no total_stool_scfa+stool Cell cycle 0.488132095 0 0 stool_scfa kegg 0.0534 NA dn no up no no no total_stool_scfa+stool Chemokine signaling pathway -0.595459236 0 0 stool_scfa kegg 0.0534 NA dn no up no no no total_stool_scfa+stool Coprococcus 0 0 0.496047431 butyrate-producing stool_scfa Genus 0.0534 0.612 dn no up no no no total_stool_scfa+stool Coronavirus disease - COVID-19 0.500515996 0 0 stool_scfa kegg 0.0534 NA dn no up no no no total_stool_scfa+stool DCA+stool 0 0 0.494071146 stool_scfa stool_bileacids 0.0534 0.195 dn no up no no no total_stool_scfa+stool EGFR tyrosine kinase inhibitor resistance 0.572755418 0 0 stool_scfa kegg 0.0534 NA dn no up no no no total_stool_scfa+stool Epithelial cell signaling in Helicobacter pylori infection -0.527347781 0 0 stool_scfa kegg 0.0534 NA dn no up no no no total_stool_scfa+stool Fusobacterium 0 0 -0.458157542 stool_scfa Genus 0.0534 0.628 dn no up no no no total_stool_scfa+stool GCDCA+stool 0 -0.587412587 0 yes stool_scfa stool_bileacids 0.0534 0.0471 dn no up no dn no total_stool_scfa+stool GDCA+stool 0 0 -0.477745041 stool_scfa stool_bileacids 0.0534 0.656 dn no up no no no total_stool_scfa+stool Gemmiger 0 0 0.41345223 butyrate-producing stool_scfa Genus 0.0534 0.595 dn no up no no no total_stool_scfa+stool HDCA+stool 0.510835913 0 0 stool_scfa stool_bileacids 0.0534 0.176 dn no up no no no total_stool_scfa+stool Inflammatory bowel disease 0 -0.645454545 0 stool_scfa kegg 0.0534 NA dn no up no no no total_stool_scfa+stool Insulin signaling pathway 0.517027864 0 0 stool_scfa kegg 0.0534 NA dn no up no no no total_stool_scfa+stool iso-DCA+stool 0.488132095 0 0 stool_scfa stool_bileacids 0.0534 0.155 dn no up no no no total_stool_scfa+stool Isobutyric acid+stool 0 0.664335664 0 stool_scfa stool_scfa 0.0534 0.408 dn no up no no no total_stool_scfa+stool Isovaleric acid+stool 0 0.657342657 0 stool_scfa stool_scfa 0.0534 0.343 dn no up no no no total_stool_scfa+stool L-Tryptophan+stool -0.525283798 0 0 stool_scfa stool_cometabolism 0.0534 0.557 dn no up no no no total_stool_scfa+stool Morphine addiction 0 0 -0.438735178 stool_scfa kegg 0.0534 NA dn no up no up up total_stool_scfa+stool mTOR signaling pathway 0.564499484 0 0 stool_scfa kegg 0.0534 NA dn no up no no no total_stool_scfa+stool Phenylacetic acid+stool 0 0.615384615 0 stool_scfa stool_cometabolism 0.0534 0.785 dn no up no no no total_stool_scfa+stool Phospholipase D signaling pathway -0.471620227 0 0 stool_scfa kegg 0.0534 NA dn no up no up up total_stool_scfa+stool Propionic acid+stool 0.876160991 0.776223776 0.87944664 yes stool_scfa stool_scfa 0.0534 0.0436 dn no up dn no up total_stool_scfa+stool Ribosome 0.496388029 0 0 stool_scfa kegg 0.0534 NA dn no up no no no total_stool_scfa+stool Roseburia 0 -0.676008042 0 butyrate-producing stool_scfa Genus 0.0534 0.495 dn no up no no no total_stool_scfa+stool T-¦Á-MCA+stool 0.507665688 0 0 stool_scfa stool_bileacids 0.0534 0.48 dn no up no no no total_stool_scfa+stool TCA+stool 0 0 -0.46541502 stool_scfa stool_bileacids 0.0534 0.458 dn no up no no no total_stool_scfa+stool TLCA+stool 0 0.678425735 0 stool_scfa stool_bileacids 0.0534 0.243 dn no up no no no total_stool_scfa+stool ¦Ø-MCA+stool -0.650312317 0 0 stool_scfa stool_bileacids 0.0534 0.919 dn no up no no no Toxoplasmosis Adrenergic signaling in cardiomyocytes -0.523478261 -0.693675889 -0.477477477 kegg kegg NA NA no no no no no up Toxoplasmosis Alcoholism -0.616521739 0 0 kegg kegg NA NA no no no no no no Toxoplasmosis Aldosterone synthesis and secretion -0.502608696 -0.7243083 -0.403603604 kegg kegg NA NA no no no no up up Toxoplasmosis alpha-Linolenic acid metabolism 0.500869565 0 0 kegg kegg NA NA no no no no no no Toxoplasmosis Alzheimer disease 0 -0.616600791 0 kegg kegg NA NA no no no no no no Toxoplasmosis Aminoacyl-tRNA biosynthesis 0.446956522 0 0 kegg kegg NA NA no no no no no no Toxoplasmosis Amphetamine addiction -0.427826087 -0.664031621 0 kegg kegg NA NA no no no no no no Toxoplasmosis AMPK signaling pathway 0 -0.658102767 0 kegg kegg NA NA no no no no no no Toxoplasmosis Amyotrophic lateral sclerosis -0.439130435 -0.595849802 0 kegg kegg NA NA no no no no no no Toxoplasmosis Anaerostipes -0.459159169 0 0 butyrate-producing kegg Genus NA 0.568 no no no no no no Toxoplasmosis Apoptosis 0 0.529644269 0 kegg kegg NA NA no no no no no no Toxoplasmosis Arginine and proline metabolism 0 0.447628458 0 kegg kegg NA NA no no no no up no Toxoplasmosis Axon guidance -0.486086957 0 0 kegg kegg NA NA no no no no up up Toxoplasmosis B cell receptor signaling pathway 0 0.572134387 0 kegg kegg NA NA no no no no no no Toxoplasmosis beta-Alanine metabolism 0.52173913 0 0.673101673 kegg kegg NA NA no no no no no no Toxoplasmosis Bile secretion -0.537391304 -0.710474308 0 kegg kegg NA NA no no no no no no Toxoplasmosis Biosynthesis of amino acids 0 0.4743083 0 kegg kegg NA NA no no no no no no Toxoplasmosis Biosynthesis of cofactors 0 -0.515810277 0 kegg kegg NA NA no no no no no no Toxoplasmosis Biosynthesis of unsaturated fatty acids 0.574782609 0 0.4996139 kegg kegg NA NA no no no no no no Toxoplasmosis C-type lectin receptor signaling pathway 0 0.54743083 0 kegg kegg NA NA no no no no no no Toxoplasmosis Calcium signaling pathway -0.494782609 -0.637351779 -0.486486486 kegg kegg NA NA no no no no up up Toxoplasmosis cAMP signaling pathway -0.473043478 0 -0.461003861 yes kegg kegg NA NA no no no no up up Toxoplasmosis Carbon metabolism 0 0.469367589 0.442213642 kegg kegg NA NA no no no no no no Toxoplasmosis Cardiac muscle contraction 0 -0.608695652 0 kegg kegg NA NA no no no no no up Toxoplasmosis Cell adhesion molecules 0 0.622529644 0 kegg kegg NA NA no no no no no no Toxoplasmosis Cellular senescence 0 0.460474308 0 kegg kegg NA NA no no no no no no Toxoplasmosis cGMP-PKG signaling pathway 0 0.494071146 0 kegg kegg NA NA no no no no no no Toxoplasmosis Cholesterol metabolism 0 0.639328063 0 yes kegg kegg NA NA no no no no no up Toxoplasmosis Circadian entrainment -0.406086957 -0.583003953 0 kegg kegg NA NA no no no no up up Toxoplasmosis Circadian rhythm 0 -0.414031621 0 kegg kegg NA NA no no no no no no Toxoplasmosis Cocaine addiction -0.46173913 -0.709486166 -0.417760618 kegg kegg NA NA no no no no no no Toxoplasmosis Cortisol synthesis and secretion -0.410434783 -0.706521739 -0.408494208 kegg kegg NA NA no no no no no up Toxoplasmosis Cushing syndrome -0.492173913 -0.660079051 -0.423680824 kegg kegg NA NA no no no no no up Toxoplasmosis Dopaminergic synapse -0.494782609 -0.776679842 -0.404890605 kegg kegg NA NA no no no no up no Toxoplasmosis Endocrine and other factor-regulated calcium reabsorption -0.470434783 -0.777667984 0 kegg kegg NA NA no no no no no no Toxoplasmosis Endocrine resistance 0 -0.630434783 0 kegg kegg NA NA no no no no no no Toxoplasmosis Endocytosis 0 0.564229249 0 kegg kegg NA NA no no no no no no Toxoplasmosis Epithelial cell signaling in Helicobacter pylori infection 0 0.459486166 0 kegg kegg NA NA no no no no no no Toxoplasmosis Fat digestion and absorption 0.434782609 0 0 yes kegg kegg NA NA no no no no up up Toxoplasmosis Fatty acid degradation 0.495652174 0.481225296 0 kegg kegg NA NA no no no no no no Toxoplasmosis Fatty acid elongation 0 0 0.556499356 kegg kegg NA NA no no no no no no Toxoplasmosis Fatty acid metabolism 0.532173913 0.47826087 0 kegg kegg NA NA no no no no no no Toxoplasmosis Fc epsilon RI signaling pathway 0 0.438735178 0 kegg kegg NA NA no no no no no no Toxoplasmosis Fc gamma R-mediated phagocytosis 0 0.530632411 0 kegg kegg NA NA no no no no no no Toxoplasmosis Galactose metabolism 0.549565217 0.481225296 0 kegg kegg NA NA no no no no no no Toxoplasmosis Gap junction 0 -0.551383399 0 kegg kegg NA NA no no no no no no Toxoplasmosis Glucagon signaling pathway -0.48 -0.682806324 0 kegg kegg NA NA no no no no no no Toxoplasmosis Glutathione metabolism 0 -0.65513834 0 kegg kegg NA NA no no no no no no Toxoplasmosis "Glycine, serine and threonine metabolism" 0 -0.593873518 0 kegg kegg NA NA no no no no up no Toxoplasmosis Glycolysis / Gluconeogenesis 0 0 0.599485199 kegg kegg NA NA no no no no no no Toxoplasmosis Glycosaminoglycan biosynthesis - keratan sulfate -0.502608696 0 -0.414157014 kegg kegg NA NA no no no no no no Toxoplasmosis Glycosaminoglycan degradation 0 0.59486166 0 kegg kegg NA NA no no no no no up Toxoplasmosis Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 -0.561389961 kegg kegg NA NA no no no no no no Toxoplasmosis Glyoxylate and dicarboxylate metabolism 0.453043478 0 0 kegg kegg NA NA no no no no no no Toxoplasmosis GnRH signaling pathway -0.530434783 -0.669960474 0 kegg kegg NA NA no no no no no no Toxoplasmosis Hematopoietic cell lineage 0.604347826 0.469367589 0.807207207 kegg kegg NA NA no no no no no no Toxoplasmosis Hippo signaling pathway - multiple species 0 0.549407115 0 kegg kegg NA NA no no no no no no Toxoplasmosis Histidine metabolism 0.584347826 0.448616601 0.489317889 kegg kegg NA NA no no no no no no Toxoplasmosis Huntington disease 0 -0.628458498 0 kegg kegg NA NA no no no no no no Toxoplasmosis IL-17 signaling pathway 0 0.509881423 0 kegg kegg NA NA no no no no no no Toxoplasmosis Inflammatory mediator regulation of TRP channels -0.474782609 -0.66798419 0 kegg kegg NA NA no no no no no no Toxoplasmosis Insulin secretion 0 -0.693675889 -0.430888031 yes kegg kegg NA NA no no no no up up Toxoplasmosis Intestinal immune network for IgA production 0 0 0.684169884 kegg kegg NA NA no no no no no no Toxoplasmosis Leishmaniasis 0 0 0.481081081 kegg kegg NA NA no no no no no no Toxoplasmosis Long-term depression -0.502608696 -0.484189723 0 kegg kegg NA NA no no no no no no Toxoplasmosis Longevity regulating pathway - multiple species 0 0.41798419 0.510682111 kegg kegg NA NA no no no no no no Toxoplasmosis Lysosome 0 0.563241107 0 kegg kegg NA NA no no no no no no Toxoplasmosis Melanogenesis -0.512173913 -0.641304348 0 kegg kegg NA NA no no no no no no Toxoplasmosis Mineral absorption -0.573043478 -0.541501976 0 kegg kegg NA NA no no no no no no Toxoplasmosis Mitophagy - animal -0.57826087 -0.631422925 0 kegg kegg NA NA no no no no no no Toxoplasmosis Morphine addiction -0.585217391 -0.764822134 0 kegg kegg NA NA no no no no up up Toxoplasmosis mRNA surveillance pathway 0 0 -0.401287001 kegg kegg NA NA no no no no no no Toxoplasmosis Natural killer cell mediated cytotoxicity 0 0.494071146 0 kegg kegg NA NA no no no no no no Toxoplasmosis Necroptosis -0.433043478 0 0 kegg kegg NA NA no no no no no no Toxoplasmosis Neuroactive ligand-receptor interaction 0 0.551383399 0 kegg kegg NA NA no no no up up up Toxoplasmosis Neurotrophin signaling pathway 0 0.433794466 -0.406435006 kegg kegg NA NA no no no no no no Toxoplasmosis NOD-like receptor signaling pathway 0.435652174 0.612648221 0 kegg kegg NA NA no no no no no no Toxoplasmosis Non-alcoholic fatty liver disease 0 -0.641304348 0 kegg kegg NA NA no no no no no no Toxoplasmosis Non-homologous end-joining 0.437391304 0 0 kegg kegg NA NA no no no no no no Toxoplasmosis Osteoclast differentiation 0 0.60770751 0 kegg kegg NA NA no no no no no no Toxoplasmosis Ovarian steroidogenesis 0 -0.727272727 0 kegg kegg NA NA no no no no up up Toxoplasmosis Oxidative phosphorylation 0 -0.613636364 0 kegg kegg NA NA no no no no no no Toxoplasmosis Pancreatic secretion -0.564347826 -0.591897233 0 kegg kegg NA NA no no no no no no Toxoplasmosis Pantothenate and CoA biosynthesis 0 0.476284585 0 kegg kegg NA NA no no no no no dn Toxoplasmosis "Parathyroid hormone synthesis, secretion and action" -0.596521739 -0.602766798 0 kegg kegg NA NA no no no no no no Toxoplasmosis Parkinson disease -0.583478261 -0.661067194 0 kegg kegg NA NA no no no no no no Toxoplasmosis Pathogenic Escherichia coli infection 0 0.578063241 0 kegg kegg NA NA no no no no no no Toxoplasmosis Pathways of neurodegeneration - multiple diseases -0.560869565 -0.651185771 0 kegg kegg NA NA no no no no no no Toxoplasmosis Pentose phosphate pathway 0 0.484189723 0 kegg kegg NA NA no no no no no no Toxoplasmosis Peroxisome 0 0.496047431 0 kegg kegg NA NA no no no no no no Toxoplasmosis Pertussis 0.414782609 0.628458498 0 kegg kegg NA NA no no no no no dn Toxoplasmosis Phagosome 0 0.580039526 0 kegg kegg NA NA no no no no no no Toxoplasmosis Phospholipase D signaling pathway 0 0 -0.467438867 kegg kegg NA NA no no no no up up Toxoplasmosis Porphyrin and chlorophyll metabolism 0 -0.491106719 0 kegg kegg NA NA no no no no no no Toxoplasmosis PPAR signaling pathway 0 0.482213439 0 kegg kegg NA NA no no no no no no Toxoplasmosis Primary bile acid biosynthesis 0.439130435 0 0.487001287 kegg kegg NA NA no no no no no no Toxoplasmosis Prion disease 0 -0.540513834 0 kegg kegg NA NA no no no no no no Toxoplasmosis Prolactin signaling pathway 0 0.427865613 0 kegg kegg NA NA no no no no no no Toxoplasmosis Protein digestion and absorption 0.697391304 0.723320158 0 yes kegg kegg NA NA no no no no up up Toxoplasmosis Purine metabolism 0 -0.59486166 0 kegg kegg NA NA no no no no no no Toxoplasmosis Pyrimidine metabolism 0.470434783 0 0 kegg kegg NA NA no no no no no no Toxoplasmosis Ras signaling pathway -0.464347826 0 0 yes kegg kegg NA NA no no no no up up Toxoplasmosis Regulation of lipolysis in adipocytes -0.529565217 -0.768774704 0 kegg kegg NA NA no no no no no no Toxoplasmosis Relaxin signaling pathway -0.502608696 0 -0.428828829 kegg kegg NA NA no no no no no no Toxoplasmosis Renin secretion -0.406086957 -0.641304348 0 kegg kegg NA NA no no no no no no Toxoplasmosis Renin-angiotensin system 0 0.619565217 0 kegg kegg NA NA no no no no no no Toxoplasmosis Retrograde endocannabinoid signaling 0 -0.640316206 0 kegg kegg NA NA no no no no no up Toxoplasmosis Ribosome -0.470434783 -0.469367589 0 kegg kegg NA NA no no no no no no Toxoplasmosis Salmonella infection 0 0.716403162 0 kegg kegg NA NA no no no no no no Toxoplasmosis Shigellosis -0.573913043 -0.518774704 0 kegg kegg NA NA no no no no no no Toxoplasmosis SNARE interactions in vesicular transport 0.44173913 0.454545455 0 kegg kegg NA NA no no no no no no Toxoplasmosis Sphingolipid signaling pathway 0 0.428853755 0 kegg kegg NA NA no no no no no no Toxoplasmosis Starch and sucrose metabolism 0 0.485177866 0 kegg kegg NA NA no no no no no no Toxoplasmosis Th1 and Th2 cell differentiation 0.488695652 0.830039526 0.484684685 kegg kegg NA NA no no no no no no Toxoplasmosis Th17 cell differentiation 0.562608696 0.835968379 0.553153153 kegg kegg NA NA no no no no no no Toxoplasmosis Thermogenesis -0.417391304 -0.60770751 0 kegg kegg NA NA no no no no no no Toxoplasmosis Thyroid hormone synthesis 0 -0.773715415 0 kegg kegg NA NA no no no no no no Toxoplasmosis Toll-like receptor signaling pathway 0 0.473320158 0 yes kegg kegg NA NA no no no no no no Toxoplasmosis Tryptophan metabolism 0.407826087 0 0.406949807 kegg kegg NA NA no no no no up no Toxoplasmosis Type I diabetes mellitus 0 0.577075099 0 kegg kegg NA NA no no no no no no Toxoplasmosis Ubiquitin mediated proteolysis -0.54 -0.645256917 0 kegg kegg NA NA no no no no no no Toxoplasmosis Vascular smooth muscle contraction -0.68173913 -0.638339921 0 kegg kegg NA NA no no no no no no Toxoplasmosis Vasopressin-regulated water reabsorption -0.463478261 -0.77173913 0 kegg kegg NA NA no no no no no no Toxoplasmosis Vitamin digestion and absorption 0 0 -0.407464607 kegg kegg NA NA no no no no no no Toxoplasmosis Wnt signaling pathway -0.487826087 0 0 kegg kegg NA NA no no no no no no Toxoplasmosis Yersinia infection 0 0.468379447 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer 2-Oxocarboxylic acid metabolism -0.484347826 -0.614624506 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer ABC transporters 0 0.564229249 0 kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Adherens junction -0.766956522 -0.848814229 -0.612612613 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Adipocytokine signaling pathway 0 0.663043478 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Adrenergic signaling in cardiomyocytes 0 -0.551383399 0 kegg kegg NA NA no no no no no up Transcriptional misregulation in cancer African trypanosomiasis 0 0.593873518 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer AGE-RAGE signaling pathway in diabetic complications 0 0.809288538 0.58970399 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer "Alanine, aspartate and glutamate metabolism" 0.513913043 0.77173913 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Aldosterone synthesis and secretion 0 -0.429841897 0 kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Aldosterone-regulated sodium reabsorption 0.455652174 0.448616601 0.454054054 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Alistipes -0.517035497 0 0 kegg Genus NA 0.0114 no no no no up no Transcriptional misregulation in cancer alpha-Linolenic acid metabolism 0 0.559288538 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Alzheimer disease 0 -0.705533597 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Amoebiasis 0 0.661067194 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Amphetamine addiction 0 -0.543478261 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer AMPK signaling pathway -0.410434783 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Amyotrophic lateral sclerosis 0 -0.708498024 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Apelin signaling pathway 0 -0.783596838 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Apoptosis 0 0.584980237 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Apoptosis - multiple species 0.412173913 0.51284585 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Arachidonic acid metabolism -0.465217391 0 -0.485971686 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Arginine and proline metabolism 0 0.723320158 0 kegg kegg NA NA no no no no up no Transcriptional misregulation in cancer Arginine biosynthesis 0.439130435 0.706521739 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Ascorbate and aldarate metabolism 0 -0.42687747 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Autophagy - animal 0.824347826 0.938735178 0.482368082 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Autophagy - other 0.790434783 0.627470356 0.605405405 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Axon guidance 0.437391304 0 0.492149292 kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer B cell receptor signaling pathway 0.448695652 0.720355731 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Bacterial invasion of epithelial cells -0.675652174 -0.749011858 -0.702702703 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Bacteroides 0 -0.427865613 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Transcriptional misregulation in cancer beta-Alanine metabolism 0 -0.536561265 -0.584555985 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Bifidobacterium 0 -0.414562935 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Transcriptional misregulation in cancer Bile secretion -0.453913043 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Biosynthesis of cofactors -0.536521739 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Butanoate metabolism 0 -0.744071146 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer C-type lectin receptor signaling pathway 0.75826087 0.774703557 0.667181467 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Calcium signaling pathway 0 0 0.408751609 kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer cAMP signaling pathway 0 0.415019763 0.421621622 yes kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Carbohydrate digestion and absorption 0.662608696 0.666007905 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Carbon metabolism 0 -0.418972332 -0.423680824 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Cardiac muscle contraction 0 -0.693675889 0 kegg kegg NA NA no no no no no up Transcriptional misregulation in cancer cGMP-PKG signaling pathway 0.511304348 0.46541502 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Chagas disease 0.410434783 0.757905138 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Chemokine signaling pathway 0 0.440711462 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Cholinergic synapse 0.537391304 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Circadian entrainment -0.529565217 -0.646245059 0 kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Circadian rhythm 0.530434783 0 0.468468468 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Citrate cycle (TCA cycle) 0 -0.733201581 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Complement and coagulation cascades 0 0.427865613 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Coronavirus disease - COVID-19 0 -0.711462451 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Cysteine and methionine metabolism 0 -0.731225296 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Cytokine-cytokine receptor interaction 0 0 -0.473873874 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Cytosolic DNA-sensing pathway 0 0.464426877 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer DNA replication 0 -0.637351779 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Dopaminergic synapse 0 -0.597826087 0 kegg kegg NA NA no no no no up no Transcriptional misregulation in cancer Drug metabolism - cytochrome P450 0 -0.822134387 -0.448906049 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Drug metabolism - other enzymes 0 -0.854743083 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer EGFR tyrosine kinase inhibitor resistance 0 -0.652173913 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Endocrine and other factor-regulated calcium reabsorption -0.525217391 -0.545454545 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Epithelial cell signaling in Helicobacter pylori infection 0 0.574110672 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer ErbB signaling pathway 0.454782609 0.617588933 0.487773488 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Estrogen signaling pathway 0 -0.593873518 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Fatty acid biosynthesis 0.485217391 0.711462451 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Fatty acid degradation 0 0.511857708 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Fatty acid elongation 0 -0.556324111 -0.415186615 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Fatty acid metabolism 0 0.451581028 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Fc epsilon RI signaling pathway 0 0.742094862 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Focal adhesion -0.723478261 -0.860671937 -0.586872587 kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer FoxO signaling pathway 0.588695652 0.754940711 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Fructose and mannose metabolism 0 0.511857708 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer GABAergic synapse 0.515652174 0.588932806 0 kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Galactose metabolism 0 0.531620553 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Gap junction -0.544347826 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Gastric acid secretion -0.873913043 -0.856719368 -0.575546976 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Glucagon signaling pathway 0 -0.550395257 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Glutamatergic synapse 0 0.416007905 0 kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Glutathione metabolism -0.494782609 -0.593873518 -0.406692407 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Glycerolipid metabolism 0 0.633399209 0 kegg kegg NA NA no no no no no up Transcriptional misregulation in cancer Glycerophospholipid metabolism 0 0.591897233 0 kegg kegg NA NA no no no no no up Transcriptional misregulation in cancer "Glycine, serine and threonine metabolism" -0.526086957 0 0 kegg kegg NA NA no no no no up no Transcriptional misregulation in cancer Glycolysis / Gluconeogenesis 0 -0.795454545 -0.50990991 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.834980237 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.57826087 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.415019763 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Glyoxylate and dicarboxylate metabolism 0 0.695652174 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer GnRH secretion 0.432173913 0.660079051 0 kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer "Growth hormone synthesis, secretion and action" 0 0.526679842 0.415958816 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Hematopoietic cell lineage 0 -0.500988142 -0.477992278 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Hepatitis B 0.853913043 0.934782609 0.76010296 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Hepatitis C 0.645217391 0.537549407 0.694465894 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer HIF-1 signaling pathway 0 -0.716403162 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Hippo signaling pathway -0.863478261 -0.845849802 -0.554697555 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Hippo signaling pathway - multiple species 0.451304348 0.72826087 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Histidine metabolism 0 0 -0.418790219 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Human papillomavirus infection 0 0.419960474 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Huntington disease 0 -0.698616601 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer IL-17 signaling pathway 0.585217391 0.449604743 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Inflammatory mediator regulation of TRP channels 0 -0.62944664 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Influenza A 0 0 -0.453024453 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Inositol phosphate metabolism 0 0.481225296 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Insulin resistance 0.759130435 0.861660079 0.787387387 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Insulin secretion -0.410434783 0 0 yes kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Insulin signaling pathway 0 -0.713438735 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer JAK-STAT signaling pathway 0 0.859683794 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Lachnospira 0 -0.465530036 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Transcriptional misregulation in cancer Legionellosis 0 -0.5 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Leishmaniasis 0 -0.599802372 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Leukocyte transendothelial migration -0.462608696 -0.497035573 -0.504247104 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Long-term potentiation 0 -0.500988142 0 kegg kegg NA NA no no no no no up Transcriptional misregulation in cancer Longevity regulating pathway 0 0.471343874 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer MAPK signaling pathway 0 0.435770751 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Measles 0.61826087 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Melanogenesis -0.546956522 -0.62055336 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Metabolism of xenobiotics by cytochrome P450 0 -0.83201581 -0.503989704 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Mismatch repair 0 -0.522727273 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer mTOR signaling pathway 0 -0.624505929 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer N-Glycan biosynthesis 0 -0.65513834 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Neurotrophin signaling pathway 0.569565217 0.623517787 0.541827542 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer NF-kappa B signaling pathway 0.663478261 0.924901186 0.786100386 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Nicotinate and nicotinamide metabolism 0.449565217 0.719367589 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Nitrogen metabolism 0 0.70256917 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer NOD-like receptor signaling pathway 0.486956522 0.776679842 0.423680824 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Non-alcoholic fatty liver disease 0 -0.592885375 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Non-homologous end-joining 0 -0.610671937 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Notch signaling pathway 0 0.509881423 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Nucleotide excision repair 0 -0.485177866 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer One carbon pool by folate 0 -0.519762846 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Oocyte meiosis 0 -0.653162055 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Osteoclast differentiation 0 0.681818182 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Other glycan degradation 0 0.495059289 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Other types of O-glycan biosynthesis 0.427826087 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Ovarian steroidogenesis -0.655652174 0 0 kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Oxidative phosphorylation 0 -0.695652174 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Oxytocin signaling pathway -0.746086957 -0.581027668 -0.598198198 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer p53 signaling pathway 0.58173913 0.527667984 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Pancreatic secretion 0 -0.561264822 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Pantothenate and CoA biosynthesis 0.436521739 0.674901186 0 kegg kegg NA NA no no no no no dn Transcriptional misregulation in cancer "Parathyroid hormone synthesis, secretion and action" 0 -0.4743083 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Parkinson disease 0 -0.612648221 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Pathogenic Escherichia coli infection 0 0 -0.413899614 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Pathways in cancer 0.506956522 0.731225296 0.672072072 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Pathways of neurodegeneration - multiple diseases 0 -0.590909091 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Pentose and glucuronate interconversions 0 -0.712450593 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Peroxisome 0.417391304 0.665019763 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Pertussis 0 0.435770751 0 kegg kegg NA NA no no no no no dn Transcriptional misregulation in cancer Phenylalanine metabolism -0.767826087 -0.764822134 -0.641956242 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Phospholipase D signaling pathway 0 0.726284585 0 kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Phototransduction 0 -0.721343874 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer PI3K-Akt signaling pathway 0.486086957 0 0 yes kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Platelet activation -0.834782609 -0.76284585 -0.524839125 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Platinum drug resistance 0.522608696 0.446640316 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Porphyrin and chlorophyll metabolism -0.49826087 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer PPAR signaling pathway 0.452173913 0.606719368 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Prevotella 0 0.427898299 0 acetate-producing kegg Genus NA 0.287 no no no no no no Transcriptional misregulation in cancer Primary bile acid biosynthesis 0 -0.497035573 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Prion disease 0 -0.772727273 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Progesterone-mediated oocyte maturation 0.631304348 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Prolactin signaling pathway 0 0.742094862 0.464607465 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Propanoate metabolism 0 -0.707509881 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Proteasome 0 -0.65513834 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Protein digestion and absorption 0 0.571146245 0 yes kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Protein export 0 -0.712450593 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Protein processing in endoplasmic reticulum 0 -0.610671937 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Proximal tubule bicarbonate reclamation 0 -0.660079051 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Pyrimidine metabolism 0 -0.513833992 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Pyruvate metabolism 0 -0.747035573 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Rap1 signaling pathway -0.62 -0.581027668 -0.451222651 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Ras signaling pathway 0 -0.654150198 0 yes kegg kegg NA NA no no no no up up Transcriptional misregulation in cancer Regulation of actin cytoskeleton -0.513043478 -0.653162055 -0.600772201 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Relaxin signaling pathway 0 0.537549407 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Renin secretion -0.619130435 -0.709486166 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Retrograde endocannabinoid signaling 0 -0.747035573 0 kegg kegg NA NA no no no no no up Transcriptional misregulation in cancer Ribosome 0 -0.721343874 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer RIG-I-like receptor signaling pathway 0.852173913 0.90513834 0.732561133 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer RNA degradation 0 -0.586956522 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer RNA polymerase 0 -0.462450593 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer RNA transport 0 -0.625494071 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Roseburia -0.48173913 0 0 butyrate-producing kegg Genus NA 0.495 no no no no no no Transcriptional misregulation in cancer Ruminococcus 0 0 0.404990835 kegg Genus NA 0.0679 no no no no no dn Transcriptional misregulation in cancer Salivary secretion -0.433913043 -0.481225296 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Salmonella infection 0 0 -0.43989704 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Selenocompound metabolism 0.448695652 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Shigellosis 0 -0.422924901 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Signaling pathways regulating pluripotency of stem cells 0 0 0.473616474 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer SNARE interactions in vesicular transport 0 0.722332016 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Sphingolipid signaling pathway 0.417391304 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Spinocerebellar ataxia 0.696521739 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Spliceosome 0.583478261 0 0.479279279 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Starch and sucrose metabolism 0 0.668972332 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Steroid biosynthesis 0 -0.491106719 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Steroid hormone biosynthesis 0 -0.54743083 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Sulfur metabolism -0.469565217 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer T cell receptor signaling pathway 0.582608696 0.627470356 0.511454311 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Taurine and hypotaurine metabolism 0 0.67687747 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer TGF-beta signaling pathway 0 -0.664031621 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Thermogenesis 0 -0.761857708 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Thiamine metabolism 0 -0.578063241 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Thyroid hormone signaling pathway -0.693913043 -0.725296443 -0.427284427 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Thyroid hormone synthesis -0.440869565 0 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Tight junction -0.712173913 -0.750988142 -0.72972973 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer TNF signaling pathway 0.611304348 0.793478261 0.474903475 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Toll-like receptor signaling pathway 0.590434783 0.743083004 0 yes kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Tryptophan metabolism 0 -0.605731225 0 kegg kegg NA NA no no no no up no Transcriptional misregulation in cancer Type II diabetes mellitus 0.606086957 0.828063241 0.421106821 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Tyrosine metabolism -0.567826087 -0.723320158 -0.620849421 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.499011858 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Ubiquitin mediated proteolysis 0 -0.436758893 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer "Valine, leucine and isoleucine degradation" 0 -0.65513834 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Various types of N-glycan biosynthesis 0 -0.47826087 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Vascular smooth muscle contraction 0 -0.681818182 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Vasopressin-regulated water reabsorption -0.514782609 -0.59486166 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer VEGF signaling pathway 0.429565217 0.505928854 0 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Vibrio cholerae infection -0.831304348 -0.76284585 -0.573230373 kegg kegg NA NA no no no no no no Transcriptional misregulation in cancer Wnt signaling pathway 0 -0.597826087 0 kegg kegg NA NA no no no no no no Tryptamine+urine 2-hydroxyhippuric acid+urine 0 0 -0.466666667 urine_cometabolism urine_cometabolism 0.0776 0.215 no no dn no no no Tryptamine+urine 3-Hydroxy-L-kynurenine+urine 0 0.457894737 0.543247863 urine_cometabolism urine_cometabolism 0.0776 0.401 no no dn no no no Tryptamine+urine 3-Hydroxytyramine hydrochloride+urine 0 0.480701754 0 urine_cometabolism urine_cometabolism 0.0776 0.288 no no dn no no no Tryptamine+urine 5-Hydroxyindole-3-acetic Acid+urine -0.613533835 0 0 urine_cometabolism urine_cometabolism 0.0776 0.0405 no no dn no dn dn Tryptamine+urine 5-Hydroxytryptamine+urine 0 0.545614035 0 urine_cometabolism urine_cometabolism 0.0776 0.171 no no dn no no no Tryptamine+urine Hippuric acid+urine 0 -0.514035088 -0.42974359 urine_cometabolism urine_cometabolism 0.0776 0.361 no no dn no no no Tryptamine+urine Indole-3-Acetic acid+urine -0.469172932 0 -0.516581197 urine_cometabolism urine_cometabolism 0.0776 0.657 no no dn no no no Tryptamine+urine L-Tryptophan+urine 0 0.573684211 0.446837607 urine_cometabolism urine_cometabolism 0.0776 0.226 no no dn no no no Tryptamine+urine L-Tyrosine+urine 0 0.564912281 0.424957265 urine_cometabolism urine_cometabolism 0.0776 0.45 no no dn no no no Tryptamine+urine P-hydroxyhippuric acid+urine 0 -0.529824561 0 urine_cometabolism urine_cometabolism 0.0776 0.436 no no dn no no no Tryptophan metabolism Arginine biosynthesis 0 -0.432806324 0 kegg kegg NA NA no up no no no no Tryptophan metabolism Ascorbate and aldarate metabolism 0.626086957 0.600790514 0.648906049 kegg kegg NA NA no up no no no no Tryptophan metabolism Citrate cycle (TCA cycle) 0.857391304 0.876482213 0.736679537 kegg kegg NA NA no up no no no no Tryptophan metabolism Cysteine and methionine metabolism 0.546956522 0.761857708 0.466409266 kegg kegg NA NA no up no no no no Tryptophan metabolism Fatty acid degradation 0.549565217 0 0.634491634 kegg kegg NA NA no up no no no no Tryptophan metabolism Fatty acid elongation 0.795652174 0.85770751 0.746718147 kegg kegg NA NA no up no no no no Tryptophan metabolism Fructose and mannose metabolism 0.65826087 0 0 kegg kegg NA NA no up no no no no Tryptophan metabolism Galactose metabolism 0.684347826 0 0 kegg kegg NA NA no up no no no no Tryptophan metabolism Glycolysis / Gluconeogenesis 0.794782609 0.738142292 0.634491634 kegg kegg NA NA no up no no no no Tryptophan metabolism Histidine metabolism 0.745217391 0.550395257 0.572200772 kegg kegg NA NA no up no no no no Tryptophan metabolism Oxidative phosphorylation -0.510434783 0 0 kegg kegg NA NA no up no no no no Tryptophan metabolism Pentose and glucuronate interconversions 0.682608696 0.743083004 0 kegg kegg NA NA no up no no no no Tryptophan metabolism Phenylalanine metabolism 0.751304348 0.801383399 0 kegg kegg NA NA no up no no no no Tryptophan metabolism Primary bile acid biosynthesis 0.86173913 0.827075099 0.552638353 kegg kegg NA NA no up no no no no Tryptophan metabolism Pyrimidine metabolism 0.776521739 0.571146245 0 kegg kegg NA NA no up no no no no Tryptophan metabolism Steroid biosynthesis 0 0.77173913 0.478764479 kegg kegg NA NA no up no no no no Tryptophan metabolism Steroid hormone biosynthesis 0.657391304 0.789525692 0 kegg kegg NA NA no up no no no no Tryptophan metabolism Synthesis and degradation of ketone bodies 0.673043478 0.681818182 0.702702703 kegg kegg NA NA no up no no no no Tryptophan metabolism Tyrosine metabolism 0.824347826 0.785573123 0.628571429 kegg kegg NA NA no up no no no no Tryptophan metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.867826087 0.806324111 0.551093951 kegg kegg NA NA no up no no no no Tryptophan metabolism "Valine, leucine and isoleucine degradation" 0.929565217 0.855731225 0.832947233 kegg kegg NA NA no up no no no no Tuberculosis Adrenergic signaling in cardiomyocytes -0.567826087 -0.649209486 -0.620592021 kegg kegg NA NA no no dn no no up Tuberculosis AGE-RAGE signaling pathway in diabetic complications 0.426086957 0.548418972 0 kegg kegg NA NA no no dn no no no Tuberculosis "Alanine, aspartate and glutamate metabolism" 0.480869565 0.486166008 0.491891892 kegg kegg NA NA no no dn no no no Tuberculosis Aldosterone synthesis and secretion -0.566956522 -0.827075099 -0.60952381 kegg kegg NA NA no no dn no up up Tuberculosis alpha-Linolenic acid metabolism 0 0 0.453024453 kegg kegg NA NA no no dn no no no Tuberculosis Alzheimer disease -0.533043478 -0.564229249 0 kegg kegg NA NA no no dn no no no Tuberculosis Aminoacyl-tRNA biosynthesis 0 -0.414031621 0 kegg kegg NA NA no no dn no no no Tuberculosis Amoebiasis 0 0.486166008 0.47979408 kegg kegg NA NA no no dn no no no Tuberculosis Amphetamine addiction -0.665217391 -0.773715415 -0.466924067 kegg kegg NA NA no no dn no no no Tuberculosis AMPK signaling pathway 0 -0.712450593 0 kegg kegg NA NA no no dn no no no Tuberculosis Amyotrophic lateral sclerosis -0.566956522 -0.618577075 0 kegg kegg NA NA no no dn no no no Tuberculosis Antifolate resistance 0 -0.595849802 0 kegg kegg NA NA no no dn no no no Tuberculosis Antigen processing and presentation 0 0.468379447 0.488288288 kegg kegg NA NA no no dn no no no Tuberculosis Apelin signaling pathway -0.637391304 -0.475296443 0 kegg kegg NA NA no no dn no no no Tuberculosis Apoptosis 0.504347826 0.690711462 0.67001287 kegg kegg NA NA no no dn no no no Tuberculosis Arginine and proline metabolism 0 0.622529644 0.438867439 kegg kegg NA NA no no dn no up no Tuberculosis Arginine biosynthesis 0.532173913 0.515810277 0.541827542 kegg kegg NA NA no no dn no no no Tuberculosis Autophagy - other -0.415652174 0 -0.436808237 kegg kegg NA NA no no dn no no no Tuberculosis B cell receptor signaling pathway 0 0.557312253 0 kegg kegg NA NA no no dn no no no Tuberculosis Bacterial invasion of epithelial cells 0 0 0.453281853 kegg kegg NA NA no no dn no no no Tuberculosis Basal transcription factors 0 -0.611660079 -0.525868726 kegg kegg NA NA no no dn no no no Tuberculosis Base excision repair 0 -0.599802372 0 kegg kegg NA NA no no dn no no no Tuberculosis beta-Alanine metabolism 0.492173913 0 0.487773488 kegg kegg NA NA no no dn no no no Tuberculosis Bile secretion -0.448695652 -0.440711462 0 kegg kegg NA NA no no dn no no no Tuberculosis Biosynthesis of amino acids 0.564347826 0.808300395 0.815701416 kegg kegg NA NA no no dn no no no Tuberculosis Biosynthesis of cofactors 0 -0.637351779 0 kegg kegg NA NA no no dn no no no Tuberculosis C-type lectin receptor signaling pathway 0 0.567193676 0 kegg kegg NA NA no no dn no no no Tuberculosis Calcium signaling pathway -0.406956522 -0.589920949 -0.619305019 kegg kegg NA NA no no dn no up up Tuberculosis cAMP signaling pathway -0.506956522 0 0 yes kegg kegg NA NA no no dn no up up Tuberculosis Carbon metabolism 0.440869565 0.619565217 0.845817246 kegg kegg NA NA no no dn no no no Tuberculosis Cardiac muscle contraction -0.46173913 -0.574110672 0 kegg kegg NA NA no no dn no no up Tuberculosis Cell adhesion molecules 0.496521739 0.759881423 0.415958816 kegg kegg NA NA no no dn no no no Tuberculosis Cell cycle -0.413043478 -0.791501976 -0.597425997 kegg kegg NA NA no no dn no no no Tuberculosis Cellular senescence 0 0.633399209 0 kegg kegg NA NA no no dn no no no Tuberculosis cGMP-PKG signaling pathway 0 0.846837945 0.467953668 kegg kegg NA NA no no dn no no no Tuberculosis Chemokine signaling pathway 0 0.515810277 0 kegg kegg NA NA no no dn no no no Tuberculosis Cholesterol metabolism 0 0.687747036 0.473101673 yes kegg kegg NA NA no no dn no no up Tuberculosis Circadian entrainment -0.452173913 0 0 kegg kegg NA NA no no dn no up up Tuberculosis Circadian rhythm -0.52173913 -0.779644269 -0.689317889 kegg kegg NA NA no no dn no no no Tuberculosis Clostridium 0 0.415672633 0 kegg Genus NA 0.925 no no dn no no no Tuberculosis Cocaine addiction -0.516521739 -0.694664032 -0.464864865 kegg kegg NA NA no no dn no no no Tuberculosis Complement and coagulation cascades 0.467826087 0.774703557 0.745688546 kegg kegg NA NA no no dn no no no Tuberculosis Cortisol synthesis and secretion -0.57826087 -0.757905138 -0.531274131 kegg kegg NA NA no no dn no no up Tuberculosis Cushing syndrome -0.642608696 -0.869565217 -0.689317889 kegg kegg NA NA no no dn no no up Tuberculosis DNA replication 0 -0.568181818 -0.451737452 kegg kegg NA NA no no dn no no no Tuberculosis Dopaminergic synapse -0.652173913 -0.540513834 -0.528442728 kegg kegg NA NA no no dn no up no Tuberculosis EGFR tyrosine kinase inhibitor resistance -0.550434783 -0.455533597 0 kegg kegg NA NA no no dn no no no Tuberculosis Endocrine and other factor-regulated calcium reabsorption -0.406086957 -0.750988142 0 kegg kegg NA NA no no dn no no no Tuberculosis Endocrine resistance -0.469565217 -0.661067194 0 kegg kegg NA NA no no dn no no no Tuberculosis Endocytosis 0.42173913 0.767786561 0 kegg kegg NA NA no no dn no no no Tuberculosis Epithelial cell signaling in Helicobacter pylori infection 0 0.711462451 0 kegg kegg NA NA no no dn no no no Tuberculosis Estrogen signaling pathway 0 -0.441699605 0 kegg kegg NA NA no no dn no no no Tuberculosis Ether lipid metabolism -0.490434783 -0.546442688 0 kegg kegg NA NA no no dn no no no Tuberculosis Fanconi anemia pathway 0 -0.579051383 -0.419305019 kegg kegg NA NA no no dn no no no Tuberculosis Fat digestion and absorption 0.500869565 0.681818182 0.645817246 yes kegg kegg NA NA no no dn no up up Tuberculosis Fatty acid biosynthesis 0.497391304 0.557312253 0 kegg kegg NA NA no no dn no no no Tuberculosis Fatty acid degradation 0.528695652 0.499011858 0.481081081 kegg kegg NA NA no no dn no no no Tuberculosis Fatty acid elongation 0.543478261 0 0.410553411 kegg kegg NA NA no no dn no no no Tuberculosis Fatty acid metabolism 0.67826087 0.600790514 0.548777349 kegg kegg NA NA no no dn no no no Tuberculosis Fc epsilon RI signaling pathway 0 0.669960474 0.431402831 kegg kegg NA NA no no dn no no no Tuberculosis Fc gamma R-mediated phagocytosis 0.729565217 0.902173913 0.818790219 kegg kegg NA NA no no dn no no no Tuberculosis Fructose and mannose metabolism 0 0 0.412612613 kegg kegg NA NA no no dn no no no Tuberculosis GABAergic synapse 0.417391304 0 0 kegg kegg NA NA no no dn no up up Tuberculosis Galactose metabolism 0.559130435 0 0 kegg kegg NA NA no no dn no no no Tuberculosis Gemmiger -0.41617744 0 0 butyrate-producing kegg Genus NA 0.595 no no dn no no no Tuberculosis Glucagon signaling pathway -0.703478261 -0.851778656 -0.726383526 kegg kegg NA NA no no dn no no no Tuberculosis Glutathione metabolism 0 -0.614624506 0 kegg kegg NA NA no no dn no no no Tuberculosis "Glycine, serine and threonine metabolism" 0 -0.602766798 0 kegg kegg NA NA no no dn no up no Tuberculosis Glycolysis / Gluconeogenesis 0 0 0.570656371 kegg kegg NA NA no no dn no no no Tuberculosis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.447826087 0 0 kegg kegg NA NA no no dn no no no Tuberculosis Glycosaminoglycan biosynthesis - keratan sulfate 0 0 -0.523294723 kegg kegg NA NA no no dn no no no Tuberculosis Glycosaminoglycan degradation 0.414782609 0.769762846 0 kegg kegg NA NA no no dn no no up Tuberculosis Glycosphingolipid biosynthesis - lacto and neolacto series 0 0 -0.44041184 kegg kegg NA NA no no dn no no no Tuberculosis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.58201581 -0.47027027 kegg kegg NA NA no no dn no no no Tuberculosis Glyoxylate and dicarboxylate metabolism 0.637391304 0.568181818 0.574002574 kegg kegg NA NA no no dn no no no Tuberculosis GnRH signaling pathway -0.449565217 -0.670948617 -0.431917632 kegg kegg NA NA no no dn no no no Tuberculosis Hedgehog signaling pathway 0 -0.616600791 -0.507850708 kegg kegg NA NA no no dn no no no Tuberculosis Hematopoietic cell lineage 0.46 0 0.455855856 kegg kegg NA NA no no dn no no no Tuberculosis HIF-1 signaling pathway -0.445217391 0 0 kegg kegg NA NA no no dn no no no Tuberculosis Hippo signaling pathway - multiple species 0.435652174 0.501976285 0 kegg kegg NA NA no no dn no no no Tuberculosis Histidine metabolism 0.424347826 0 0.4996139 kegg kegg NA NA no no dn no no no Tuberculosis Homologous recombination 0 -0.45256917 -0.400772201 kegg kegg NA NA no no dn no no no Tuberculosis Huntington disease -0.513043478 -0.589920949 0 kegg kegg NA NA no no dn no no no Tuberculosis IL-17 signaling pathway 0.417391304 0.848814229 0.602831403 kegg kegg NA NA no no dn no no no Tuberculosis Inflammatory mediator regulation of TRP channels -0.51826087 -0.652173913 -0.53976834 kegg kegg NA NA no no dn no no no Tuberculosis Insulin resistance 0 0 -0.426769627 kegg kegg NA NA no no dn no no no Tuberculosis Insulin secretion -0.493043478 -0.774703557 -0.535649936 yes kegg kegg NA NA no no dn no up up Tuberculosis Insulin signaling pathway -0.587826087 -0.435770751 0 kegg kegg NA NA no no dn no no no Tuberculosis Intestinal immune network for IgA production 0 0 0.428828829 kegg kegg NA NA no no dn no no no Tuberculosis Leukocyte transendothelial migration 0 0 0.637323037 kegg kegg NA NA no no dn no no no Tuberculosis Lysine degradation 0 -0.580039526 -0.528957529 kegg kegg NA NA no no dn no no no Tuberculosis Lysosome 0.600869565 0.928853755 0.787129987 kegg kegg NA NA no no dn no no no Tuberculosis Mannose type O-glycan biosynthesis 0 -0.488142292 -0.571943372 kegg kegg NA NA no no dn no no no Tuberculosis Melanogenesis -0.506956522 -0.672924901 -0.568082368 kegg kegg NA NA no no dn no no no Tuberculosis Mineral absorption -0.497391304 -0.473320158 0 kegg kegg NA NA no no dn no no no Tuberculosis Mismatch repair 0 -0.437747036 0 kegg kegg NA NA no no dn no no no Tuberculosis Mitophagy - animal -0.708695652 -0.617588933 0 kegg kegg NA NA no no dn no no no Tuberculosis Morphine addiction -0.464347826 -0.654150198 0 kegg kegg NA NA no no dn no up up Tuberculosis mRNA surveillance pathway -0.513043478 -0.734189723 -0.746718147 kegg kegg NA NA no no dn no no no Tuberculosis mTOR signaling pathway -0.603478261 -0.438735178 0 kegg kegg NA NA no no dn no no no Tuberculosis N-Glycan biosynthesis -0.445217391 -0.611660079 -0.459459459 kegg kegg NA NA no no dn no no no Tuberculosis Natural killer cell mediated cytotoxicity 0.405217391 0.693675889 0 kegg kegg NA NA no no dn no no no Tuberculosis Necroptosis -0.452173913 0 0 kegg kegg NA NA no no dn no no no Tuberculosis Neuroactive ligand-receptor interaction 0 0.904150198 0.761132561 kegg kegg NA NA no no dn up up up Tuberculosis Neutrophil extracellular trap formation 0.729565217 0.869565217 0.811325611 kegg kegg NA NA no no dn no no no Tuberculosis Nicotinate and nicotinamide metabolism 0.574782609 0.640316206 0.546460746 kegg kegg NA NA no no dn no no no Tuberculosis Nicotine addiction 0 -0.503952569 0 kegg kegg NA NA no no dn no up up Tuberculosis Nitrogen metabolism 0 0.446640316 0 kegg kegg NA NA no no dn no no no Tuberculosis NOD-like receptor signaling pathway 0.591304348 0.635375494 0 kegg kegg NA NA no no dn no no no Tuberculosis Non-alcoholic fatty liver disease -0.56173913 -0.541501976 -0.425740026 kegg kegg NA NA no no dn no no no Tuberculosis Nucleotide excision repair 0 -0.591897233 0 kegg kegg NA NA no no dn no no no Tuberculosis Olfactory transduction 0 0.777667984 0.738481338 kegg kegg NA NA no no dn no no no Tuberculosis One carbon pool by folate 0 -0.590909091 -0.416988417 kegg kegg NA NA no no dn no no no Tuberculosis Oocyte meiosis -0.456521739 0 0 kegg kegg NA NA no no dn no no no Tuberculosis Osteoclast differentiation 0.559130435 0.796442688 0.59047619 kegg kegg NA NA no no dn no no no Tuberculosis Other types of O-glycan biosynthesis -0.468695652 -0.647233202 -0.496267696 kegg kegg NA NA no no dn no no no Tuberculosis Ovarian steroidogenesis 0 -0.51284585 0 kegg kegg NA NA no no dn no up up Tuberculosis Oxidative phosphorylation -0.487826087 -0.540513834 0 kegg kegg NA NA no no dn no no no Tuberculosis Oxytocin signaling pathway 0 0 0.503474903 kegg kegg NA NA no no dn no no no Tuberculosis p53 signaling pathway 0 -0.431818182 -0.550579151 kegg kegg NA NA no no dn no no no Tuberculosis Pancreatic secretion -0.462608696 -0.558300395 0 kegg kegg NA NA no no dn no no no Tuberculosis Pantothenate and CoA biosynthesis 0.536521739 0.708498024 0.610553411 kegg kegg NA NA no no dn no no dn Tuberculosis "Parathyroid hormone synthesis, secretion and action" -0.771304348 -0.555335968 -0.41956242 kegg kegg NA NA no no dn no no no Tuberculosis Parkinson disease -0.7 -0.56916996 -0.405662806 kegg kegg NA NA no no dn no no no Tuberculosis Pathogenic Escherichia coli infection 0.487826087 0.786561265 0.67001287 kegg kegg NA NA no no dn no no no Tuberculosis Pathways of neurodegeneration - multiple diseases -0.699130435 -0.600790514 -0.411325611 kegg kegg NA NA no no dn no no no Tuberculosis Pentose and glucuronate interconversions 0 -0.435770751 0 kegg kegg NA NA no no dn no no no Tuberculosis Pentose phosphate pathway 0.555652174 0.898221344 0.762934363 kegg kegg NA NA no no dn no no no Tuberculosis Peroxisome 0.568695652 0.633399209 0.470785071 kegg kegg NA NA no no dn no no no Tuberculosis Pertussis 0.676521739 0.91798419 0.82960103 kegg kegg NA NA no no dn no no dn Tuberculosis Phagosome 0.62 0.836956522 0.628314028 kegg kegg NA NA no no dn no no no Tuberculosis Phosphatidylinositol signaling system 0 -0.448616601 -0.546718147 kegg kegg NA NA no no dn no no no Tuberculosis PI3K-Akt signaling pathway -0.482608696 0 0 yes kegg kegg NA NA no no dn no up up Tuberculosis Porphyrin and chlorophyll metabolism 0 -0.564229249 0 kegg kegg NA NA no no dn no no no Tuberculosis PPAR signaling pathway 0 0.665019763 0.455083655 kegg kegg NA NA no no dn no no no Tuberculosis Primary bile acid biosynthesis 0 0 0.603346203 kegg kegg NA NA no no dn no no no Tuberculosis Prion disease -0.511304348 -0.502964427 0 kegg kegg NA NA no no dn no no no Tuberculosis Prolactin signaling pathway 0 0.475296443 0 kegg kegg NA NA no no dn no no no Tuberculosis Protein digestion and absorption 0.674782609 0.696640316 0 yes kegg kegg NA NA no no dn no up up Tuberculosis Protein export -0.6 0 -0.496010296 kegg kegg NA NA no no dn no no no Tuberculosis Protein processing in endoplasmic reticulum -0.66173913 -0.703557312 -0.413899614 kegg kegg NA NA no no dn no no no Tuberculosis Proximal tubule bicarbonate reclamation 0 -0.499011858 0 kegg kegg NA NA no no dn no no no Tuberculosis Purine metabolism 0 -0.72826087 0 kegg kegg NA NA no no dn no no no Tuberculosis Pyrimidine metabolism 0 -0.498023715 0 kegg kegg NA NA no no dn no no no Tuberculosis Pyruvate metabolism 0 -0.441699605 0 kegg kegg NA NA no no dn no no no Tuberculosis Ras signaling pathway 0 0 -0.46048906 yes kegg kegg NA NA no no dn no up up Tuberculosis Regulation of lipolysis in adipocytes -0.496521739 -0.564229249 0 kegg kegg NA NA no no dn no no no Tuberculosis Relaxin signaling pathway -0.566086957 0 0 kegg kegg NA NA no no dn no no no Tuberculosis Renin secretion -0.462608696 -0.542490119 0 kegg kegg NA NA no no dn no no no Tuberculosis Renin-angiotensin system 0.523478261 0.914031621 0.57039897 kegg kegg NA NA no no dn no no no Tuberculosis Retrograde endocannabinoid signaling 0 -0.504940711 0 kegg kegg NA NA no no dn no no up Tuberculosis Ribosome -0.715652174 -0.480237154 0 kegg kegg NA NA no no dn no no no Tuberculosis Ribosome biogenesis in eukaryotes -0.41826087 -0.722332016 -0.551351351 kegg kegg NA NA no no dn no no no Tuberculosis RNA degradation -0.432173913 -0.663043478 -0.563963964 kegg kegg NA NA no no dn no no no Tuberculosis RNA polymerase -0.508695652 -0.792490119 -0.503732304 kegg kegg NA NA no no dn no no no Tuberculosis Salmonella infection 0.503478261 0.776679842 0.697554698 kegg kegg NA NA no no dn no no no Tuberculosis Selenocompound metabolism 0 -0.459486166 0 kegg kegg NA NA no no dn no no no Tuberculosis Shigellosis -0.605217391 0 0 kegg kegg NA NA no no dn no no no Tuberculosis Signaling pathways regulating pluripotency of stem cells 0 -0.445652174 -0.486229086 kegg kegg NA NA no no dn no no no Tuberculosis Sphingolipid metabolism 0.453043478 0 0.451737452 kegg kegg NA NA no no dn no no no Tuberculosis Sphingolipid signaling pathway 0 0.612648221 0 kegg kegg NA NA no no dn no no no Tuberculosis Spinocerebellar ataxia -0.425217391 -0.624505929 0 kegg kegg NA NA no no dn no no no Tuberculosis Spliceosome 0 -0.469367589 -0.51969112 kegg kegg NA NA no no dn no no no Tuberculosis Staphylococcus aureus infection 0.92173913 0.963438735 0.927155727 kegg kegg NA NA no no dn up no no Tuberculosis Starch and sucrose metabolism 0.428695652 0.604743083 0.584041184 kegg kegg NA NA no no dn no no no Tuberculosis Steroid biosynthesis -0.42 0 0 kegg kegg NA NA no no dn no no no Tuberculosis Synaptic vesicle cycle 0 0.805335968 0.581209781 kegg kegg NA NA no no dn no up up Tuberculosis Synthesis and degradation of ketone bodies 0 -0.446640316 0 kegg kegg NA NA no no dn no no no Tuberculosis Taste transduction 0 -0.586956522 -0.400514801 kegg kegg NA NA no no dn no no up Tuberculosis Taurine and hypotaurine metabolism 0 0 -0.445302445 kegg kegg NA NA no no dn no no no Tuberculosis Th1 and Th2 cell differentiation 0 0.416007905 0 kegg kegg NA NA no no dn no no no Tuberculosis Thermogenesis -0.539130435 -0.572134387 0 kegg kegg NA NA no no dn no no no Tuberculosis Thyroid hormone synthesis -0.533913043 -0.708498024 0 kegg kegg NA NA no no dn no no no Tuberculosis Tight junction 0 0 0.519176319 kegg kegg NA NA no no dn no no no Tuberculosis Toll-like receptor signaling pathway 0 0.625494071 0 yes kegg kegg NA NA no no dn no no no Tuberculosis Toxoplasmosis 0.566086957 0.691699605 0.563191763 kegg kegg NA NA no no dn no no no Tuberculosis Type I diabetes mellitus 0.476521739 0.694664032 0 kegg kegg NA NA no no dn no no no Tuberculosis Ubiquitin mediated proteolysis -0.726086957 -0.709486166 0 kegg kegg NA NA no no dn no no no Tuberculosis Various types of N-glycan biosynthesis -0.524347826 -0.461462451 0 kegg kegg NA NA no no dn no no no Tuberculosis Vascular smooth muscle contraction -0.622608696 0 0 kegg kegg NA NA no no dn no no no Tuberculosis Vasopressin-regulated water reabsorption -0.497391304 -0.660079051 0 kegg kegg NA NA no no dn no no no Tuberculosis Wnt signaling pathway 0 -0.698616601 -0.571171171 kegg kegg NA NA no no dn no no no Tuberculosis Yersinia infection 0.483478261 0.791501976 0.473359073 kegg kegg NA NA no no dn no no no TUDCA+blood 11-HETE+blood 0 0.573131914 0 yes serum_bileacids serum_ARA 0.0282 0.464 no no dn no no no TUDCA+blood 12-ketoDCA+stool -0.628970902 0 0 yes serum_bileacids stool_bileacids 0.0282 0.505 no no dn no no no TUDCA+blood 14:0/16:0-PC+blood -0.450602565 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.0358 no no dn no up no TUDCA+blood 16:0/14:0-PC+blood -0.462460527 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.0206 no no dn no up up TUDCA+blood 16:0/16:0-PC+blood -0.604756074 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.00079 no no dn no up up TUDCA+blood 16:0/16:1-PI+blood 0 0.55704523 0 yes serum_bileacids serum_phospholipids 0.0282 0.262 no no dn no no no TUDCA+blood 16:0/18:1-PC+blood -0.549418917 0 0 yes serum_bileacids serum_phospholipids 0.0282 6.15E-07 no no dn up up up TUDCA+blood 16:0/18:1-PE+blood 0.470365835 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.000107 no no dn up up no TUDCA+blood 16:0/18:2-PC+blood -0.468389508 0 0 yes serum_bileacids serum_phospholipids 0.0282 3.24E-06 no no dn no up up TUDCA+blood 16:0/20:4-PC+blood -0.606732401 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.0262 no no dn no up no TUDCA+blood 16:0/20:4-PI+blood 0 0 -0.414208319 yes serum_bileacids serum_phospholipids 0.0282 0.558 no no dn no no no TUDCA+blood 16:1/16:0-PC+blood -0.480247471 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.0215 no no dn no up up TUDCA+blood 16:1/16:1-PC+blood -0.490129106 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.0177 no no dn no no up TUDCA+blood 18:0/16:0-PC+blood -0.590921785 0 0 yes serum_bileacids serum_phospholipids 0.0282 9.64E-07 no no dn up up up TUDCA+blood 18:0/18:1-PE+blood 0 0.493931731 0 yes serum_bileacids serum_phospholipids 0.0282 0.00716 no no dn up up no TUDCA+blood 18:0/18:2-PI+blood 0.480247471 0 -0.424005625 yes serum_bileacids serum_phospholipids 0.0282 0.179 no no dn no no no TUDCA+blood 18:0/20:4-PC+blood -0.606732401 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.454 no no dn no no no TUDCA+blood 18:0/22:6-PI+blood 0 0 -0.41094255 yes serum_bileacids serum_phospholipids 0.0282 0.425 no no dn no no no TUDCA+blood 18:1/16:0-PC+blood -0.531631974 0 0 yes serum_bileacids serum_phospholipids 0.0282 2.43E-05 no no dn no up up TUDCA+blood 18:1/18:2-PE+blood 0.496058087 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.000293 no no dn up up no TUDCA+blood 18:1/20:4-PI+blood 0 -0.544696937 0 yes serum_bileacids serum_phospholipids 0.0282 0.192 no no dn no no no TUDCA+blood 18:3-LPC+blood 0.519774011 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.147 no no dn no no no TUDCA+blood 18:3/18:2-PC+blood 0.466413181 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.0394 no no dn no no up TUDCA+blood 20-HDOHE+blood -0.444453938 0 0 yes serum_bileacids serum_ARA 0.0282 0.205 no no dn no no no TUDCA+blood 20:0-LPC+blood 0.476294817 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.199 no no dn no no no TUDCA+blood 20:0-LPE+blood 0.519774011 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.0615 no no dn no no up TUDCA+blood 20:2/18:1-PE+blood 0.56720586 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.00208 no no dn up up no TUDCA+blood 20:3/16:0-PC+blood -0.606732401 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.00405 no no dn no up up TUDCA+blood 20:3n6+blood 0.503963395 0 0 yes serum_bileacids serum_fattyacid 0.0282 0.0884 no no dn up no no TUDCA+blood 20:4-LPE+blood 0 -0.485699536 0 yes serum_bileacids serum_phospholipids 0.0282 0.552 no no dn no no no TUDCA+blood 20:4/16:0-PE+blood 0.500010741 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.00529 no no dn no up up TUDCA+blood 20:4n6+blood -0.482223798 0 0 yes serum_bileacids serum_fattyacid 0.0282 0.133 no no dn no no no TUDCA+blood ACA+blood -0.527912176 0 0 yes serum_bileacids serum_bileacids 0.0282 0.338 no no dn no no no TUDCA+blood Alcoholism 0 -0.518776512 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Alzheimer disease 0 0.51539686 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Amphetamine addiction 0 0.561022156 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Amyotrophic lateral sclerosis 0 0.650582922 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Anaerostipes 0 0 0.457788218 yes butyrate-producing serum_bileacids Genus 0.0282 0.568 no no dn no no no TUDCA+blood Biosynthesis of amino acids 0 -0.682689612 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Bladder cancer 0 -0.498498602 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Butyric acid+stool -0.620235195 0 0 yes yes serum_bileacids stool_scfa 0.0282 0.102 no no dn dn no no TUDCA+blood C-type lectin receptor signaling pathway 0 0 -0.413223022 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood CA+stool 0.620235195 0 0 yes serum_bileacids stool_bileacids 0.0282 0.827 no no dn no no no TUDCA+blood Calcium signaling pathway 0 0 -0.4843022 yes serum_bileacids kegg 0.0282 NA no no dn no up up TUDCA+blood capric acid C6+blood 0 0 0.492586766 yes serum_bileacids serum_scfa 0.0282 0.433 no no dn no no no TUDCA+blood CDCA+blood 0 0.646227348 0 yes serum_bileacids serum_bileacids 0.0282 0.506 no no dn no no no TUDCA+blood CDCA+stool 0.628970902 0 0 yes serum_bileacids stool_bileacids 0.0282 0.663 no no dn no no no TUDCA+blood Cell cycle 0 0.525535815 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Cellular senescence 0 -0.569471285 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood cGMP-PKG signaling pathway 0 -0.613406755 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Clostridium 0.595849692 0 0 yes serum_bileacids Genus 0.0282 0.925 no no dn no no no TUDCA+blood Cysteine+blood 0 -0.532348644 0 yes yes serum_bileacids serum_aminoacids 0.0282 1.81E-07 no no dn dn up up TUDCA+blood d18:1-18:0-SM+blood -0.462460527 0 0 yes serum_bileacids serum_phospholipids 0.0282 0.97 no no dn no no no TUDCA+blood DCA+stool -0.620235195 0 0 yes serum_bileacids stool_bileacids 0.0282 0.195 no no dn no no no TUDCA+blood Endocytosis 0 -0.557642504 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Epithelial cell signaling in Helicobacter pylori infection 0 -0.564401808 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Fc gamma R-mediated phagocytosis 0 -0.528915466 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood GABAergic synapse 0 -0.594818671 0 yes serum_bileacids kegg 0.0282 NA no no dn no up up TUDCA+blood GCA+blood 0 0.654459544 0 yes yes serum_bileacids serum_bileacids 0.0282 0.16 no no dn no no no TUDCA+blood GCDCA+blood 0 0.798522966 0 yes serum_bileacids serum_bileacids 0.0282 0.31 no no dn no no no TUDCA+blood Gemmiger -0.604756074 0 0 yes butyrate-producing serum_bileacids Genus 0.0282 0.595 no no dn no no no TUDCA+blood Glycolysis / Gluconeogenesis 0 0 0.439727122 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood GUDCA+blood 0.575111169 0.791662803 0 yes serum_bileacids serum_bileacids 0.0282 0.0766 no no dn no no dn TUDCA+blood HCA+blood 0 0.512591464 0 yes serum_bileacids serum_bileacids 0.0282 0.544 no no dn no no no TUDCA+blood HDCA+stool -0.620235195 0 0 yes serum_bileacids stool_bileacids 0.0282 0.176 no no dn no no no TUDCA+blood Hepatitis B 0 0 -0.452979172 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Hepatitis C 0 0 -0.480688005 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Human papillomavirus infection 0 -0.564401808 -0.401175703 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Huntington disease 0 0.51539686 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood iso-LCA+blood -0.527912176 0 0 yes serum_bileacids serum_bileacids 0.0282 0.507 no no dn no no no TUDCA+blood iso-LCA+stool -0.625462792 0 0 yes serum_bileacids stool_bileacids 0.0282 0.72 no no dn no no no TUDCA+blood isovaleric acid iso-C5+blood 0 0 -0.476257923 yes serum_bileacids serum_scfa 0.0282 0.117 no no dn no no no TUDCA+blood L-Aspartic acid+blood -0.496058087 0 0 yes yes serum_bileacids serum_aminoacids 0.0282 0.0226 no no dn up up no TUDCA+blood L-Tyrosine+blood 0 0.492559699 0 yes yes serum_bileacids serum_aminoacids 0.0282 0.00913 no no dn up up no TUDCA+blood LCA+blood -0.527912176 0 0 yes serum_bileacids serum_bileacids 0.0282 0.884 no no dn no no no TUDCA+blood LCA+stool -0.628970902 0 0 yes serum_bileacids stool_bileacids 0.0282 0.314 no no dn no no no TUDCA+blood Lipid and atherosclerosis 0 -0.54750355 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Longevity regulating pathway - multiple species 0 0 0.401175703 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood mRNA surveillance pathway 0 0.586369543 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Natural killer cell mediated cytotoxicity 0 -0.571161111 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Neurotrophin signaling pathway 0 0 -0.437317658 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Neutrophil extracellular trap formation 0 -0.501878254 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Nicotinate and nicotinamide metabolism 0 -0.599888149 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood nutriCA+stool 0.628970902 0 0 yes serum_bileacids stool_bileacids 0.0282 0.481 no no dn no no no TUDCA+blood Olfactory transduction 0 -0.586369543 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Oxidative phosphorylation 0 0.505257906 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Pathogenic Escherichia coli infection 0 -0.549193376 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Pathways of neurodegeneration - multiple diseases 0 0.508637557 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Pertussis 0 -0.517086686 0 yes serum_bileacids kegg 0.0282 NA no no dn no no dn TUDCA+blood Phagosome 0 -0.525535815 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Phenylacetic acid+stool 0 -0.62122474 0 yes serum_bileacids stool_cometabolism 0.0282 0.785 no no dn no no no TUDCA+blood Phospholipase D signaling pathway 0 -0.542434073 0 yes serum_bileacids kegg 0.0282 NA no no dn no up up TUDCA+blood PPAR signaling pathway 0 -0.535674769 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Prion disease 0 0.561022156 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Prostate cancer 0 0 -0.466231223 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Protein processing in endoplasmic reticulum 0 0.520466337 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood PUFA/UFA+blood -0.464436854 0 0 yes serum_bileacids serum_fattyacid 0.0282 0.000732 no no dn dn no up TUDCA+blood PUFA%+blood -0.476294817 0 0 yes serum_bileacids serum_fattyacid 0.0282 0.0013 no no dn dn no up TUDCA+blood Ribosome biogenesis in eukaryotes 0 0.498498602 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood RIG-I-like receptor signaling pathway 0 0 -0.416837217 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood RNA degradation 0 0.566091633 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Sarcosine+blood 0 0 -0.504561251 yes serum_bileacids serum_choline 0.0282 5.06E-05 no no dn up up no TUDCA+blood SFA%+blood -0.484200125 0 0 yes serum_bileacids serum_fattyacid 0.0282 0.0236 no no dn no up no TUDCA+blood TCA+blood 0.505570557 0.742118422 0.43830895 yes serum_bileacids serum_bileacids 0.0282 0.339 no no dn no no no TUDCA+blood Thermogenesis 0 0.500188428 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood TMAO+blood -0.478271144 0 0 yes serum_bileacids serum_choline 0.0282 0.00706 no no dn up up no TUDCA+blood total_blood_scfa+blood 0 0 0.563889381 yes serum_bileacids serum_scfa 0.0282 0.168 no no dn no no no TUDCA+blood Ubiquitin mediated proteolysis 0 0.540744247 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Viral carcinogenesis 0 -0.552573027 -0.414427753 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+blood Wnt signaling pathway 0 0.569471285 0 yes serum_bileacids kegg 0.0282 NA no no dn no no no TUDCA+stool 3-(3-Hydroxyphenyl)propanoic acid+stool 0 -0.590785249 0 stool_bileacids stool_cometabolism 0.241 0.33 no no no no no no TUDCA+stool 5-Hydroxytryptamine+stool -0.641327881 0 0 stool_bileacids stool_cometabolism 0.241 0.00862 no no no dn dn no TUDCA+stool Butyricicoccus 0 0.703597545 0 butyrate-producing stool_bileacids Genus 0.241 0.852 no no no no no no TUDCA+stool CA+stool 0 0 -0.427038114 stool_bileacids stool_bileacids 0.241 0.827 no no no no no no TUDCA+stool Central carbon metabolism in cancer 0 -0.768634 0 stool_bileacids kegg 0.241 NA no no no no no no TUDCA+stool Coprococcus 0 0.611587546 0 butyrate-producing stool_bileacids Genus 0.241 0.612 no no no no no no TUDCA+stool GCA+stool -0.618386071 0 0 stool_bileacids stool_bileacids 0.241 0.0809 no no no no no no TUDCA+stool GCDCA+stool -0.745608838 0 0 yes stool_bileacids stool_bileacids 0.241 0.0471 no no no no dn no TUDCA+stool GDCA+stool -0.502893768 0 0 stool_bileacids stool_bileacids 0.241 0.656 no no no no no no TUDCA+stool GUDCA+stool 0 0.603985292 0 yes stool_bileacids stool_bileacids 0.241 0.0085 no no no no dn no TUDCA+stool L-Phenylalanine+stool 0 0 0.487744512 stool_bileacids stool_cometabolism 0.241 0.398 no no no no no no TUDCA+stool L-Tyrosine+stool 0 0.682315358 0.494024484 stool_bileacids stool_cometabolism 0.241 0.44 no no no no no no TUDCA+stool Legionellosis 0 -0.663341671 0 stool_bileacids kegg 0.241 NA no no no no no no TUDCA+stool nutriCA+stool 0 0 -0.539030952 stool_bileacids stool_bileacids 0.241 0.481 no no no no no no TUDCA+stool Propionic acid+stool 0.528704449 0 0 yes stool_bileacids stool_scfa 0.241 0.0436 no no no dn no up TUDCA+stool Relaxin signaling pathway 0 0.610695507 0 stool_bileacids kegg 0.241 NA no no no no no no TUDCA+stool T-¦Á-MCA+stool 0 0.906522023 0 stool_bileacids stool_bileacids 0.241 0.48 no no no no no no TXB2+blood 11-HETE+blood -0.592394158 -0.785626534 -0.419042409 yes serum_ARA serum_ARA 0.0644 0.464 dn no no no no no TXB2+blood 14:0/16:0-PC+blood 0 -0.579976497 0 yes serum_ARA serum_phospholipids 0.0644 0.0358 dn no no no up no TXB2+blood 14:0/18:0-PC+blood 0 -0.790421533 0 yes serum_ARA serum_phospholipids 0.0644 0.00289 dn no no up up no TXB2+blood 16:0-LPC+blood 0.474398128 0 0 yes serum_ARA serum_phospholipids 0.0644 0.00456 dn no no up up no TXB2+blood 16:0/16:0-PI+blood 0 -0.631335107 0 yes serum_ARA serum_phospholipids 0.0644 0.358 dn no no no no no TXB2+blood 16:0/16:1-PC+blood 0 -0.787916235 0 yes serum_ARA serum_phospholipids 0.0644 0.00283 dn no no up up no TXB2+blood 16:0/16:1-PI+blood 0 -0.75534736 0 yes serum_ARA serum_phospholipids 0.0644 0.262 dn no no no no no TXB2+blood 16:0/18:1-PE+blood 0 -0.584987093 0 yes serum_ARA serum_phospholipids 0.0644 0.000107 dn no no up up no TXB2+blood 16:0/18:2-PI+blood 0 -0.587492391 0 yes serum_ARA serum_phospholipids 0.0644 0.269 dn no no no no no TXB2+blood 16:0/20:4-PE+blood 0 0 -0.476028095 yes serum_ARA serum_phospholipids 0.0644 0.00139 dn no no up up no TXB2+blood 16:0/22:0-PE+blood 0 0.572460603 0 yes serum_ARA serum_phospholipids 0.0644 0.00839 dn no no dn no up TXB2+blood 16:0/22:6-PC+blood 0 0.661398684 0 yes serum_ARA serum_phospholipids 0.0644 4.53E-05 dn no no no up up TXB2+blood 16:1/16:0-PC+blood 0 0.558681464 0 yes serum_ARA serum_phospholipids 0.0644 0.0215 dn no no no up up TXB2+blood 16:1/18:1-PG+blood 0 0 -0.430480083 yes serum_ARA serum_phospholipids 0.0644 3.21E-05 dn no no no up up TXB2+blood 18:0/18:0-PE+blood 0 -0.598766233 0 yes serum_ARA serum_phospholipids 0.0644 0.00896 dn no no up up no TXB2+blood 18:0/18:1-PE+blood 0 -0.598766233 0 yes serum_ARA serum_phospholipids 0.0644 0.00716 dn no no up up no TXB2+blood 18:0/18:1-PI+blood 0 -0.729041731 0 yes serum_ARA serum_phospholipids 0.0644 0.599 dn no no no no no TXB2+blood 18:0/20:3-PC+blood 0 -0.518596695 0 yes serum_ARA serum_phospholipids 0.0644 0.0682 dn no no no up no TXB2+blood 18:0/20:4-PC+blood 0 0.655135439 0 yes serum_ARA serum_phospholipids 0.0644 0.454 dn no no no no no TXB2+blood 18:0/20:5-PC+blood 0 0.812969215 0 yes serum_ARA serum_phospholipids 0.0644 0.17 dn no no no no no TXB2+blood 18:0/22:6-PC+blood 0.475904154 0.592502987 0 yes serum_ARA serum_phospholipids 0.0644 0.0775 dn no no no no up TXB2+blood 18:1-LPE+blood -0.593374167 0 0 yes serum_ARA serum_phospholipids 0.0644 0.117 dn no no no no no TXB2+blood 18:1/16:0-PE+blood 0 -0.564944709 0 yes serum_ARA serum_phospholipids 0.0644 0.000182 dn no no up up no TXB2+blood 18:1/16:0-PI+blood 0 -0.655135439 0 yes serum_ARA serum_phospholipids 0.0644 0.793 dn no no no no no TXB2+blood 18:1/16:1-PE+blood 0 -0.571207954 0 yes serum_ARA serum_phospholipids 0.0644 0.000184 dn no no up up no TXB2+blood 18:1/18:0-PE+blood 0 -0.541144378 0 yes serum_ARA serum_phospholipids 0.0644 1.39E-06 dn no no up up no TXB2+blood 18:1/18:0-PI+blood 0 -0.486027821 0 yes serum_ARA serum_phospholipids 0.0644 0.0931 dn no no no no up TXB2+blood 18:1/18:1-PC+blood 0 -0.538639079 0 yes serum_ARA serum_phospholipids 0.0644 1.34E-05 dn no no no up up TXB2+blood 18:1/18:1-PE+blood 0 -0.519849344 0 yes serum_ARA serum_phospholipids 0.0644 1.03E-05 dn no no up up no TXB2+blood 18:1/18:1-PG+blood 0 -0.541144378 -0.457192451 yes serum_ARA serum_phospholipids 0.0644 0.00352 dn no no no up up TXB2+blood 18:1/18:2-PE+blood 0 -0.53738643 0 yes serum_ARA serum_phospholipids 0.0644 0.000293 dn no no up up no TXB2+blood 18:1/18:2-PG+blood 0 -0.498554311 0 yes serum_ARA serum_phospholipids 0.0644 5.58E-07 dn no no no up up TXB2+blood 18:1/20:4-PC+blood 0 0.787916235 0 yes serum_ARA serum_phospholipids 0.0644 0.582 dn no no no no no TXB2+blood 18:2/18:2-PS+blood 0 -0.7691265 0 yes serum_ARA serum_phospholipids 0.0644 0.00674 dn no no up up no TXB2+blood 18:2n6c+blood 0 0 0.467123972 yes serum_ARA serum_fattyacid 0.0644 0.15 dn no no no no no TXB2+blood 18:3/16:0-PE+blood 0 -0.501059609 0 yes serum_ARA serum_phospholipids 0.0644 0.00149 dn no no up up no TXB2+blood 18:3n3+blood 0 0 0.575000843 yes serum_ARA serum_fattyacid 0.0644 0.291 dn no no no no no TXB2+blood 20:0-LPE+blood 0 0 0.457877384 yes serum_ARA serum_phospholipids 0.0644 0.0615 dn no no no no up TXB2+blood 20:0/20:4-PE+blood 0 -0.579976497 0 yes serum_ARA serum_phospholipids 0.0644 0.00128 dn no no up up no TXB2+blood 20:0/20:5-PC+blood 0 0.488533119 0 yes serum_ARA serum_phospholipids 0.0644 0.882 dn no no no no no TXB2+blood 20:1-LPC+blood -0.531627109 0 0 yes serum_ARA serum_phospholipids 0.0644 0.217 dn no no no no no TXB2+blood 20:1-LPE+blood -0.625000709 0 0 yes serum_ARA serum_phospholipids 0.0644 0.465 dn no no no no no TXB2+blood 20:1/20:4-PC+blood 0 0.501059609 0 yes serum_ARA serum_phospholipids 0.0644 0.0419 dn no no no no up TXB2+blood 20:2-LPC+blood 0 0 0.479110291 yes serum_ARA serum_phospholipids 0.0644 0.119 dn no no no no up TXB2+blood 20:2/18:0-PC+blood 0 -0.492291066 0 yes serum_ARA serum_phospholipids 0.0644 0.0427 dn no no no up no TXB2+blood 20:2/18:1-PE+blood 0 -0.601271531 0 yes serum_ARA serum_phospholipids 0.0644 0.00208 dn no no up up no TXB2+blood 20:3-LPC+blood 0 -0.587492391 0 yes serum_ARA serum_phospholipids 0.0644 0.0292 dn no no no up no TXB2+blood 20:3n6+blood 0 -0.70398875 0 yes serum_ARA serum_fattyacid 0.0644 0.0884 dn no no up no no TXB2+blood 20:4-LPC+blood 0 0.556176166 0 yes serum_ARA serum_phospholipids 0.0644 0.949 dn no no no no no TXB2+blood 20:4/16:0-PE+blood 0 -0.577471199 0 yes serum_ARA serum_phospholipids 0.0644 0.00529 dn no no no up up TXB2+blood 20:4/18:0-PE+blood 0 0 -0.460274647 yes serum_ARA serum_phospholipids 0.0644 0.000755 dn no no up up no TXB2+blood 20:4n6+blood 0 0.527365238 0 yes serum_ARA serum_fattyacid 0.0644 0.133 dn no no no no no TXB2+blood 20:5/18:0-PC+blood 0 0.577471199 0 yes serum_ARA serum_phospholipids 0.0644 3.97E-06 dn no no no up up TXB2+blood 22:6-LPC+blood 0 0.633840405 0 yes serum_ARA serum_phospholipids 0.0644 0.127 dn no no no no up TXB2+blood 22:6n3+blood 0 0.56369206 0 yes serum_ARA serum_fattyacid 0.0644 0.792 dn no no no no no TXB2+blood 8-HETE+blood 0.596386219 0.488533119 0.449658193 yes serum_ARA serum_ARA 0.0644 0.741 dn no no no no no TXB2+blood AA+blood 0.600904296 0.511080801 0 yes serum_ARA serum_ARA 0.0644 0.212 dn no no no no no TXB2+blood Adrenergic signaling in cardiomyocytes 0 0 -0.405010386 yes serum_ARA kegg 0.0644 NA dn no no no no up TXB2+blood Alzheimer disease -0.5202117 -0.561256548 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Amyotrophic lateral sclerosis -0.51142434 -0.576183584 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Antigen processing and presentation 0 0 -0.438921817 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Bacteroides 0.445783638 0 0 yes LPS-producing serum_ARA Genus 0.0644 0.000267 dn no no dn dn up TXB2+blood Bifidobacterium 0.452730986 0 0 yes acetate-producing serum_ARA Genus 0.0644 0.105 dn no no no dn no TXB2+blood Cardiac muscle contraction -0.544816307 -0.570212769 0 yes serum_ARA kegg 0.0644 NA dn no no no no up TXB2+blood Cellular senescence 0 0 -0.419653958 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Choline+blood 0 0 0.407534844 yes serum_ARA serum_choline 0.0644 0.0395 dn no no no up no TXB2+blood Cholinergic synapse 0 0.528417069 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood d18:1-18:0-SM+blood 0 0.559934113 0 yes serum_ARA serum_phospholipids 0.0644 0.97 dn no no no no no TXB2+blood d18:1-20:1-SM+blood 0 0.632587756 0 yes serum_ARA serum_phospholipids 0.0644 0.0992 dn no no no no no TXB2+blood decanoic acid C10+blood 0 -0.71776789 0 yes serum_ARA serum_mcfa 0.0644 6.64E-11 dn no no dn dn no TXB2+blood Diabetic cardiomyopathy -0.560633555 -0.561256548 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood EPA+blood 0 0.690209611 0 yes serum_ARA serum_ARA 0.0644 0.212 dn no no no no no TXB2+blood Epstein-Barr virus infection 0 0 -0.44662896 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood GCA+stool 0 0 -0.448288862 yes serum_ARA stool_bileacids 0.0644 0.0809 dn no no no no no TXB2+blood GCDCA+blood 0 -0.528617887 0 yes serum_ARA serum_bileacids 0.0644 0.31 dn no no no no no TXB2+blood GCDCA+stool 0 -0.66529621 0 yes yes serum_ARA stool_bileacids 0.0644 0.0471 dn no no no dn no TXB2+blood GDCA+stool -0.66851849 0 0 yes serum_ARA stool_bileacids 0.0644 0.656 dn no no no no no TXB2+blood HCA+blood 0 -0.483994878 0 yes serum_ARA serum_bileacids 0.0644 0.544 dn no no no no no TXB2+blood Herpes simplex virus 1 infection 0 0 -0.478613605 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Human cytomegalovirus infection 0 0 -0.482852534 yes serum_ARA kegg 0.0644 NA dn no no no no dn TXB2+blood Human immunodeficiency virus 1 infection 0 0 -0.442775388 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Human T-cell leukemia virus 1 infection 0 0 -0.502120393 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Huntington disease -0.536028947 -0.59111062 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Kaposi sarcoma-associated herpesvirus infection 0 -0.594096027 0 yes serum_ARA kegg 0.0644 NA dn no no no no dn TXB2+blood L-Aspartic acid+blood 0.480422232 0 0 yes yes serum_ARA serum_aminoacids 0.0644 0.0226 dn no no up up no TXB2+blood L-Homocystine+blood -0.695783922 0 0 yes serum_ARA serum_aminoacids 0.0644 0.197 dn no no no no no TXB2+blood L-Proline+blood 0 -0.509828152 0 yes yes serum_ARA serum_aminoacids 0.0644 0.00265 dn no no up up no TXB2+blood L-Tyrosine+blood 0 -0.569955305 0 yes yes serum_ARA serum_aminoacids 0.0644 0.00913 dn no no up up no TXB2+blood Long-term potentiation 0 0 -0.414258958 yes serum_ARA kegg 0.0644 NA dn no no no no up TXB2+blood MAPK signaling pathway 0 0.743366385 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Methanobrevibacter 0 0 0.469440946 yes serum_ARA Genus 0.0644 0.629 dn no no no no no TXB2+blood n3+blood 0 0.582481795 0 yes serum_ARA serum_fattyacid 0.0644 0.806 dn no no no no no TXB2+blood Neurotrophin signaling pathway -0.50263698 0 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Non-alcoholic fatty liver disease -0.488577204 -0.61200847 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood nutriCA+stool 0 0 -0.455810487 yes serum_ARA stool_bileacids 0.0644 0.481 dn no no no no no TXB2+blood Oxidative phosphorylation -0.488577204 -0.576183584 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Parabacteroides 0 0.482269873 0 yes serum_ARA Genus 0.0644 4.19E-05 dn no no no up up TXB2+blood Parkinson disease -0.499122036 -0.513490033 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Pathways of neurodegeneration - multiple diseases -0.504394452 0 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Phenylacetic acid+stool 0 0.739734947 0 yes serum_ARA stool_cometabolism 0.0644 0.785 dn no no no no no TXB2+blood Prion disease -0.497364564 -0.540358698 -0.457418961 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Prostate cancer -0.469245013 0 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Proteoglycans in cancer 0 0 -0.518690751 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood PUFA/MUFA+blood 0 0 0.511644586 yes serum_ARA serum_fattyacid 0.0644 0.00108 dn no no dn no up TXB2+blood Retrograde endocannabinoid signaling -0.495607092 0 0 yes serum_ARA kegg 0.0644 NA dn no no no no up TXB2+blood Roseburia 0.454819793 -0.531448928 0 yes butyrate-producing serum_ARA Genus 0.0644 0.495 dn no no no no no TXB2+blood Ruminococcus 0 -0.518288046 0 yes serum_ARA Genus 0.0644 0.0679 dn no no no no dn TXB2+blood Serine+blood 0 0.53738643 0 yes serum_ARA serum_aminoacids 0.0644 0.942 dn no no no no no TXB2+blood Shigellosis 0 -0.507519219 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood TCA+stool 0 -0.618772 0 yes serum_ARA stool_bileacids 0.0644 0.458 dn no no no no no TXB2+blood Th17 cell differentiation -0.458700181 0 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood Thermogenesis 0 -0.567227362 0 yes serum_ARA kegg 0.0644 NA dn no no no no no TXB2+blood TMAO+blood 0 0.554923517 0 yes serum_ARA serum_choline 0.0644 0.00706 dn no no up up no TXB2+blood TUDCA+blood 0 -0.567286586 0 yes yes serum_ARA serum_bileacids 0.0644 0.0282 dn no no no no dn Type I diabetes mellitus 2-Oxocarboxylic acid metabolism 0.462608696 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Adrenergic signaling in cardiomyocytes 0 -0.453557312 0 kegg kegg NA NA no no no no no up Type I diabetes mellitus Aldosterone synthesis and secretion 0 -0.618577075 0 kegg kegg NA NA no no no no up up Type I diabetes mellitus Amino sugar and nucleotide sugar metabolism 0 0 -0.414414414 kegg kegg NA NA no no no no no no Type I diabetes mellitus AMPK signaling pathway 0 -0.677865613 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Antifolate resistance 0 0 -0.457400257 kegg kegg NA NA no no no no no no Type I diabetes mellitus Antigen processing and presentation 0.469565217 0.520750988 0.648906049 kegg kegg NA NA no no no no no no Type I diabetes mellitus Apelin signaling pathway -0.459130435 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Apoptosis 0 0.712450593 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Apoptosis - multiple species 0 0 -0.551866152 kegg kegg NA NA no no no no no no Type I diabetes mellitus Autophagy - other -0.580869565 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus B cell receptor signaling pathway 0 0.483201581 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Bacteroides 0.433043478 0 0 LPS-producing kegg Genus NA 0.000267 no no no dn dn up Type I diabetes mellitus Basal transcription factors -0.592173913 -0.577075099 -0.534362934 kegg kegg NA NA no no no no no no Type I diabetes mellitus Base excision repair 0 -0.518774704 -0.432175032 kegg kegg NA NA no no no no no no Type I diabetes mellitus Biosynthesis of amino acids 0.570434783 0.583003953 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Biosynthesis of cofactors 0 -0.847826087 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Butyricicoccus 0 0 0.475661054 butyrate-producing kegg Genus NA 0.852 no no no no no no Type I diabetes mellitus C-type lectin receptor signaling pathway 0 0.529644269 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus cAMP signaling pathway -0.452173913 0 0 yes kegg kegg NA NA no no no no up up Type I diabetes mellitus Carbon metabolism 0.477391304 0.470355731 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Cardiac muscle contraction -0.428695652 0 0 kegg kegg NA NA no no no no no up Type I diabetes mellitus Cell adhesion molecules 0.957391304 0.961462451 0.944401544 kegg kegg NA NA no no no no no no Type I diabetes mellitus Cell cycle -0.607826087 -0.604743083 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Cellular senescence 0.830434783 0.936758893 0.888803089 kegg kegg NA NA no no no no no no Type I diabetes mellitus cGMP-PKG signaling pathway 0 0.527667984 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Chemokine signaling pathway 0 0.448616601 0.466924067 kegg kegg NA NA no no no no no no Type I diabetes mellitus Circadian entrainment 0 -0.414031621 0 kegg kegg NA NA no no no no up up Type I diabetes mellitus Circadian rhythm -0.499130435 -0.497035573 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Complement and coagulation cascades 0.528695652 0.56916996 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Cortisol synthesis and secretion 0 -0.635375494 0 kegg kegg NA NA no no no no no up Type I diabetes mellitus Cushing syndrome 0 -0.700592885 0 kegg kegg NA NA no no no no no up Type I diabetes mellitus Cytosolic DNA-sensing pathway 0 0 0.477220077 kegg kegg NA NA no no no no no no Type I diabetes mellitus Dopaminergic synapse -0.44 -0.536561265 0 kegg kegg NA NA no no no no up no Type I diabetes mellitus Endocrine resistance 0 -0.566205534 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Endocytosis 0.833043478 0.945652174 0.910939511 kegg kegg NA NA no no no no no no Type I diabetes mellitus Estrogen signaling pathway -0.426956522 -0.492094862 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Ether lipid metabolism -0.502608696 -0.697628458 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Fanconi anemia pathway 0 -0.550395257 -0.463320463 kegg kegg NA NA no no no no no no Type I diabetes mellitus Fc epsilon RI signaling pathway 0 0.58201581 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Fc gamma R-mediated phagocytosis 0 0.544466403 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Folate biosynthesis -0.459130435 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus FoxO signaling pathway 0 0 -0.527155727 kegg kegg NA NA no no no no no no Type I diabetes mellitus Glucagon signaling pathway 0 -0.635375494 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Glutathione metabolism 0 -0.551383399 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Glycerophospholipid metabolism -0.487826087 -0.459486166 0 kegg kegg NA NA no no no no no up Type I diabetes mellitus "Glycine, serine and threonine metabolism" 0 -0.789525692 0 kegg kegg NA NA no no no no up no Type I diabetes mellitus Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.424347826 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Glycosaminoglycan degradation 0 0.625494071 0 kegg kegg NA NA no no no no no up Type I diabetes mellitus Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.755928854 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus GnRH signaling pathway 0 -0.563241107 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Hedgehog signaling pathway 0 -0.433794466 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Homologous recombination 0 -0.492094862 -0.532046332 kegg kegg NA NA no no no no no no Type I diabetes mellitus IL-17 signaling pathway 0 0.561264822 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Inflammatory mediator regulation of TRP channels 0 -0.431818182 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Insulin resistance -0.462608696 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Insulin secretion 0 -0.577075099 0 yes kegg kegg NA NA no no no no up up Type I diabetes mellitus Insulin signaling pathway -0.450434783 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Leukocyte transendothelial migration 0.511304348 0.495059289 0.409266409 kegg kegg NA NA no no no no no no Type I diabetes mellitus Long-term potentiation -0.473913043 0 0 kegg kegg NA NA no no no no no up Type I diabetes mellitus Longevity regulating pathway 0 -0.47826087 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Lysosome 0 0.701581028 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus MAPK signaling pathway -0.595652174 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Melanogenesis 0 -0.41798419 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Mismatch repair 0 -0.540513834 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Mitophagy - animal 0 -0.507905138 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus mRNA surveillance pathway -0.593043478 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Natural killer cell mediated cytotoxicity 0.822608696 0.951581028 0.902960103 kegg kegg NA NA no no no no no no Type I diabetes mellitus Neuroactive ligand-receptor interaction 0 0.608695652 0 kegg kegg NA NA no no no up up up Type I diabetes mellitus Neurotrophin signaling pathway 0 0.499011858 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Neutrophil extracellular trap formation 0.406086957 0.605731225 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus NOD-like receptor signaling pathway 0 0.496047431 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Non-alcoholic fatty liver disease -0.504347826 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Nucleotide excision repair 0 -0.585968379 -0.534362934 kegg kegg NA NA no no no no no no Type I diabetes mellitus One carbon pool by folate 0 -0.540513834 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Oocyte meiosis -0.542608696 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Osteoclast differentiation 0 0.593873518 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Other types of O-glycan biosynthesis -0.529565217 -0.522727273 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Ovarian steroidogenesis 0 -0.473320158 0 kegg kegg NA NA no no no no up up Type I diabetes mellitus Oxidative phosphorylation -0.460869565 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus p53 signaling pathway -0.511304348 -0.476284585 -0.542084942 kegg kegg NA NA no no no no no no Type I diabetes mellitus "Parathyroid hormone synthesis, secretion and action" -0.406086957 -0.447628458 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Pentose phosphate pathway 0.453043478 0.659090909 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Phagosome 0.895652174 0.913043478 0.814929215 kegg kegg NA NA no no no no no no Type I diabetes mellitus PI3K-Akt signaling pathway -0.53826087 0 0 yes kegg kegg NA NA no no no no up up Type I diabetes mellitus Platinum drug resistance 0 0 -0.575289575 kegg kegg NA NA no no no no no no Type I diabetes mellitus Porphyrin and chlorophyll metabolism 0 -0.751976285 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus PPAR signaling pathway 0 0.456521739 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Progesterone-mediated oocyte maturation -0.429565217 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Prolactin signaling pathway 0 0.464426877 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Protein export -0.557391304 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Protein processing in endoplasmic reticulum 0 -0.472332016 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Purine metabolism 0 -0.754940711 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Pyrimidine metabolism 0 -0.422924901 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Pyruvate metabolism 0 -0.43083004 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Renin secretion 0 -0.419960474 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Renin-angiotensin system 0 0.675889328 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Retrograde endocannabinoid signaling -0.517391304 0 0 kegg kegg NA NA no no no no no up Type I diabetes mellitus Ribosome biogenesis in eukaryotes -0.432173913 -0.526679842 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus RNA degradation -0.503478261 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus RNA polymerase -0.46173913 -0.563241107 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Ruminococcus 0 0 0.400772201 acetate-producing kegg Genus NA 0.335 no no no no no no Type I diabetes mellitus Selenocompound metabolism -0.53826087 -0.518774704 -0.467696268 kegg kegg NA NA no no no no no no Type I diabetes mellitus Sphingolipid metabolism 0 0.453557312 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Sphingolipid signaling pathway 0 0.71541502 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Spliceosome -0.415652174 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Steroid biosynthesis -0.605217391 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Synaptic vesicle cycle 0 0.459486166 0 kegg kegg NA NA no no no no up up Type I diabetes mellitus Synthesis and degradation of ketone bodies 0 -0.585968379 -0.424453024 kegg kegg NA NA no no no no no no Type I diabetes mellitus Taste transduction -0.659130435 -0.58201581 0 kegg kegg NA NA no no no no no up Type I diabetes mellitus Taurine and hypotaurine metabolism -0.414782609 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Terpenoid backbone biosynthesis -0.695652174 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Th1 and Th2 cell differentiation 0 0.585968379 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Th17 cell differentiation 0 0.557312253 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Thermogenesis -0.436521739 0 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Thiamine metabolism 0 -0.598814229 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Thyroid hormone synthesis 0 -0.509881423 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Toll-like receptor signaling pathway 0 0.490118577 0.459202059 yes kegg kegg NA NA no no no no no no Type I diabetes mellitus Tyrosine metabolism 0 -0.450592885 0 kegg kegg NA NA no no no no no no Type I diabetes mellitus Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.442687747 -0.421621622 kegg kegg NA NA no no no no no no Type I diabetes mellitus Ubiquitin mediated proteolysis 0 -0.56916996 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus 2-Oxocarboxylic acid metabolism -0.531304348 -0.486166008 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus ABC transporters 0 0.544466403 0.40978121 kegg kegg NA NA no no no no up up Type II diabetes mellitus Adherens junction -0.453913043 -0.683794466 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Adipocytokine signaling pathway 0 0.461462451 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus "Alanine, aspartate and glutamate metabolism" 0 0.567193676 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Antigen processing and presentation 0 -0.490118577 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Apelin signaling pathway 0 -0.615612648 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Apoptosis 0 0.47826087 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Apoptosis - multiple species 0 0.499011858 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Arachidonic acid metabolism -0.586086957 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Arginine and proline metabolism 0 0.59486166 0 kegg kegg NA NA no no no no up no Type II diabetes mellitus Arginine biosynthesis 0 0.500988142 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Ascorbate and aldarate metabolism 0 -0.418972332 0.416473616 kegg kegg NA NA no no no no no no Type II diabetes mellitus Autophagy - animal 0.807826087 0.830039526 0.697039897 kegg kegg NA NA no no no no no no Type II diabetes mellitus Autophagy - other 0.594782609 0.580039526 0.423680824 kegg kegg NA NA no no no no no no Type II diabetes mellitus B cell receptor signaling pathway 0.416521739 0.656126482 0.444787645 kegg kegg NA NA no no no no no no Type II diabetes mellitus beta-Alanine metabolism -0.570434783 -0.556324111 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Biosynthesis of cofactors -0.619130435 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Biosynthesis of unsaturated fatty acids -0.610434783 -0.470355731 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Butanoate metabolism -0.607826087 -0.609683794 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus C-type lectin receptor signaling pathway 0.806086957 0.674901186 0.533590734 kegg kegg NA NA no no no no no no Type II diabetes mellitus cAMP signaling pathway 0.539130435 0 0 yes kegg kegg NA NA no no no no up up Type II diabetes mellitus Carbon metabolism -0.466086957 -0.432806324 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Cardiac muscle contraction 0 -0.557312253 0 kegg kegg NA NA no no no no no up Type II diabetes mellitus cGMP-PKG signaling pathway 0.496521739 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Cholinergic synapse 0.714782609 0.461462451 0.54980695 kegg kegg NA NA no no no no no no Type II diabetes mellitus Circadian entrainment 0 -0.545454545 -0.538738739 kegg kegg NA NA no no no no up up Type II diabetes mellitus Circadian rhythm 0.523478261 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Citrate cycle (TCA cycle) -0.56173913 -0.710474308 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Cysteine and methionine metabolism 0 -0.623517787 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus DNA replication 0 -0.519762846 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Dopaminergic synapse 0 -0.467391304 0 kegg kegg NA NA no no no no up no Type II diabetes mellitus Drug metabolism - cytochrome P450 -0.407826087 -0.726284585 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Drug metabolism - other enzymes -0.539130435 -0.778656126 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus EGFR tyrosine kinase inhibitor resistance 0 -0.438735178 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus ErbB signaling pathway 0.759130435 0.881422925 0.612097812 kegg kegg NA NA no no no no no no Type II diabetes mellitus Estrogen signaling pathway 0 -0.497035573 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Fatty acid biosynthesis 0 0.603754941 0.445559846 kegg kegg NA NA no no no no no no Type II diabetes mellitus Fatty acid degradation 0 0.420948617 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Fatty acid elongation -0.655652174 -0.570158103 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Fc epsilon RI signaling pathway 0.574782609 0.671936759 0.629343629 kegg kegg NA NA no no no no no no Type II diabetes mellitus Focal adhesion -0.455652174 -0.736166008 0 kegg kegg NA NA no no no no up up Type II diabetes mellitus FoxO signaling pathway 0.510434783 0.753952569 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Fructose and mannose metabolism 0 0.540513834 0.460746461 kegg kegg NA NA no no no no no no Type II diabetes mellitus GABAergic synapse 0 0.509881423 0 kegg kegg NA NA no no no no up up Type II diabetes mellitus Galactose metabolism 0 0.532608696 0.526640927 kegg kegg NA NA no no no no no no Type II diabetes mellitus Gap junction 0 0 -0.483912484 kegg kegg NA NA no no no no no no Type II diabetes mellitus Glutamatergic synapse 0 0.419960474 0 kegg kegg NA NA no no no no up up Type II diabetes mellitus Glutathione metabolism -0.490434783 -0.528656126 -0.469240669 kegg kegg NA NA no no no no no no Type II diabetes mellitus Glycerolipid metabolism 0 0.638339921 0.512998713 kegg kegg NA NA no no no no no up Type II diabetes mellitus Glycerophospholipid metabolism 0 0.565217391 0.517117117 kegg kegg NA NA no no no no no up Type II diabetes mellitus "Glycine, serine and threonine metabolism" -0.506956522 0 0 kegg kegg NA NA no no no no up no Type II diabetes mellitus Glycolysis / Gluconeogenesis -0.517391304 -0.756916996 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.512173913 0.842885375 0.492149292 kegg kegg NA NA no no no no no no Type II diabetes mellitus Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.470434783 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Glycosaminoglycan degradation 0 0 0.467438867 kegg kegg NA NA no no no no no up Type II diabetes mellitus Glycosphingolipid biosynthesis - lacto and neolacto series 0 0.416007905 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Glyoxylate and dicarboxylate metabolism 0 0.493083004 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus GnRH secretion 0.802608696 0.87944664 0.717374517 kegg kegg NA NA no no no no up up Type II diabetes mellitus Hedgehog signaling pathway 0 0 0.44967825 kegg kegg NA NA no no no no no no Type II diabetes mellitus HIF-1 signaling pathway 0 -0.575098814 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Hippo signaling pathway -0.520869565 -0.661067194 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Hippo signaling pathway - multiple species 0 0.549407115 0.564993565 kegg kegg NA NA no no no no no no Type II diabetes mellitus IL-17 signaling pathway 0.451304348 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Inflammatory mediator regulation of TRP channels 0 -0.43972332 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Inositol phosphate metabolism 0 0.553359684 0.512483912 kegg kegg NA NA no no no no no no Type II diabetes mellitus Insulin signaling pathway 0 -0.53458498 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus JAK-STAT signaling pathway 0.452173913 0.799407115 0.501673102 kegg kegg NA NA no no no no no no Type II diabetes mellitus Long-term potentiation 0 -0.446640316 0 kegg kegg NA NA no no no no no up Type II diabetes mellitus Longevity regulating pathway 0.410434783 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Lysine degradation 0 0 0.426512227 kegg kegg NA NA no no no no no no Type II diabetes mellitus MAPK signaling pathway 0 0.466403162 0.542084942 kegg kegg NA NA no no no no no no Type II diabetes mellitus Melanogenesis 0 -0.436758893 -0.404118404 kegg kegg NA NA no no no no no no Type II diabetes mellitus Metabolism of xenobiotics by cytochrome P450 -0.46 -0.764822134 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Mismatch repair -0.551304348 -0.480237154 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Mitophagy - animal 0 0 -0.491634492 kegg kegg NA NA no no no no no no Type II diabetes mellitus mTOR signaling pathway 0 -0.434782609 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus N-Glycan biosynthesis 0 -0.428853755 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Necroptosis 0 0 -0.437837838 kegg kegg NA NA no no no no no no Type II diabetes mellitus Neurotrophin signaling pathway 0.680869565 0.593873518 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus NF-kappa B signaling pathway 0.473913043 0.793478261 0.507078507 kegg kegg NA NA no no no no no no Type II diabetes mellitus Nicotinate and nicotinamide metabolism 0 0.580039526 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Nitrogen metabolism 0 0.493083004 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus NOD-like receptor signaling pathway 0 0.612648221 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Non-homologous end-joining -0.602608696 -0.565217391 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Notch signaling pathway 0.456521739 0.681818182 0.572715573 kegg kegg NA NA no no no no no no Type II diabetes mellitus Nucleotide excision repair 0 -0.423913043 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Oocyte meiosis 0 -0.593873518 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Osteoclast differentiation 0 0.532608696 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Other glycan degradation 0 0.468379447 0.556241956 kegg kegg NA NA no no no no no no Type II diabetes mellitus Other types of O-glycan biosynthesis 0 0 0.434234234 kegg kegg NA NA no no no no no no Type II diabetes mellitus Ovarian steroidogenesis 0 0 -0.427541828 kegg kegg NA NA no no no no up up Type II diabetes mellitus Oxidative phosphorylation 0 -0.608695652 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Oxytocin signaling pathway -0.440869565 -0.579051383 -0.443500644 kegg kegg NA NA no no no no no no Type II diabetes mellitus p53 signaling pathway 0.42173913 0.440711462 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Pantothenate and CoA biosynthesis 0 0.435770751 0 kegg kegg NA NA no no no no no dn Type II diabetes mellitus Pentose and glucuronate interconversions -0.667826087 -0.621541502 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Phenylalanine metabolism -0.65826087 -0.64229249 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Phosphatidylinositol signaling system 0 0 0.453024453 kegg kegg NA NA no no no no no no Type II diabetes mellitus Phospholipase D signaling pathway 0 0.674901186 0 kegg kegg NA NA no no no no up up Type II diabetes mellitus Phototransduction 0 -0.792490119 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Platelet activation -0.466956522 -0.630434783 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Platinum drug resistance 0 0.537549407 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Porphyrin and chlorophyll metabolism -0.448695652 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus PPAR signaling pathway 0 0.434782609 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Primary bile acid biosynthesis -0.571304348 -0.589920949 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Progesterone-mediated oocyte maturation 0.586956522 0.484189723 0.482625483 kegg kegg NA NA no no no no no no Type II diabetes mellitus Prolactin signaling pathway 0.774782609 0.727272727 0.762162162 kegg kegg NA NA no no no no no no Type II diabetes mellitus Propanoate metabolism 0 -0.626482213 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Proteasome 0 -0.763833992 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Protein export 0 -0.646245059 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Protein processing in endoplasmic reticulum 0 -0.47826087 -0.473616474 kegg kegg NA NA no no no no no no Type II diabetes mellitus Pyrimidine metabolism -0.427826087 -0.449604743 0.482110682 kegg kegg NA NA no no no no no no Type II diabetes mellitus Pyruvate metabolism -0.412173913 -0.668972332 -0.412612613 kegg kegg NA NA no no no no no no Type II diabetes mellitus Rap1 signaling pathway 0 -0.455533597 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Regulation of actin cytoskeleton -0.546086957 -0.666007905 -0.468468468 kegg kegg NA NA no no no no no no Type II diabetes mellitus Relaxin signaling pathway 0.569565217 0.504940711 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Renin secretion 0 -0.618577075 -0.538223938 kegg kegg NA NA no no no no no no Type II diabetes mellitus Retinol metabolism -0.433043478 0 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Retrograde endocannabinoid signaling 0 -0.684782609 0 kegg kegg NA NA no no no no no up Type II diabetes mellitus Ribosome 0 -0.593873518 -0.502960103 kegg kegg NA NA no no no no no no Type II diabetes mellitus RIG-I-like receptor signaling pathway 0.672173913 0.752964427 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus RNA transport 0 -0.418972332 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Selenocompound metabolism 0 0 0.435778636 kegg kegg NA NA no no no no no no Type II diabetes mellitus Signaling pathways regulating pluripotency of stem cells 0.694782609 0.687747036 0.492921493 kegg kegg NA NA no no no no no no Type II diabetes mellitus SNARE interactions in vesicular transport 0 0.561264822 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Sphingolipid metabolism 0 0 0.457657658 kegg kegg NA NA no no no no no no Type II diabetes mellitus Sphingolipid signaling pathway 0.725217391 0 0.473616474 kegg kegg NA NA no no no no no no Type II diabetes mellitus Spliceosome 0 0.444664032 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Starch and sucrose metabolism 0 0.52173913 0.502702703 kegg kegg NA NA no no no no no no Type II diabetes mellitus Steroid biosynthesis 0 -0.52173913 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Steroid hormone biosynthesis -0.588695652 -0.436758893 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Sulfur metabolism -0.58 -0.456521739 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus T cell receptor signaling pathway 0.509565217 0.554347826 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Taste transduction 0 0 0.410553411 kegg kegg NA NA no no no no no up Type II diabetes mellitus Taurine and hypotaurine metabolism 0.429565217 0.776679842 0.446846847 kegg kegg NA NA no no no no no no Type II diabetes mellitus TGF-beta signaling pathway 0 -0.529644269 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Thermogenesis 0 -0.632411067 -0.545945946 kegg kegg NA NA no no no no no no Type II diabetes mellitus Thiamine metabolism 0 -0.496047431 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Thyroid hormone signaling pathway 0 -0.468379447 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Thyroid hormone synthesis 0 0 -0.518146718 kegg kegg NA NA no no no no no no Type II diabetes mellitus Tight junction -0.597391304 -0.774703557 -0.441184041 kegg kegg NA NA no no no no no no Type II diabetes mellitus TNF signaling pathway 0.8 0.756916996 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Toll-like receptor signaling pathway 0.760869565 0.62055336 0 yes kegg kegg NA NA no no no no no no Type II diabetes mellitus Tryptophan metabolism -0.583478261 -0.609683794 0 kegg kegg NA NA no no no no up no Type II diabetes mellitus Tyrosine metabolism -0.669565217 -0.585968379 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Ubiquinone and other terpenoid-quinone biosynthesis -0.557391304 -0.447628458 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Ubiquitin mediated proteolysis 0 -0.434782609 -0.506563707 kegg kegg NA NA no no no no no no Type II diabetes mellitus "Valine, leucine and isoleucine degradation" -0.531304348 -0.564229249 0 kegg kegg NA NA no no no no no no Type II diabetes mellitus Vascular smooth muscle contraction 0 -0.670948617 -0.524581725 kegg kegg NA NA no no no no no no Type II diabetes mellitus VEGF signaling pathway 0.732173913 0.721343874 0.52046332 kegg kegg NA NA no no no no no no Type II diabetes mellitus Viral protein interaction with cytokine and cytokine receptor 0 0 -0.483655084 kegg kegg NA NA no no no no no no Tyrosine metabolism "Alanine, aspartate and glutamate metabolism" 0 -0.522727273 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Arginine and proline metabolism 0 -0.561264822 0 kegg kegg NA NA no no no no up no Tyrosine metabolism Arginine biosynthesis 0 -0.537549407 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Ascorbate and aldarate metabolism 0.513043478 0.47826087 0.418018018 kegg kegg NA NA no no no no no no Tyrosine metabolism Citrate cycle (TCA cycle) 0.76 0.820158103 0.58043758 kegg kegg NA NA no no no no no no Tyrosine metabolism Cysteine and methionine metabolism 0.633913043 0.804347826 0.555212355 kegg kegg NA NA no no no no no no Tyrosine metabolism Fatty acid biosynthesis 0 -0.480237154 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Fatty acid degradation 0 0 0.421106821 kegg kegg NA NA no no no no no no Tyrosine metabolism Fatty acid elongation 0.674782609 0.621541502 0.69009009 kegg kegg NA NA no no no no no no Tyrosine metabolism Fructose and mannose metabolism 0.440869565 0 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Galactose metabolism 0.448695652 0 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Glycolysis / Gluconeogenesis 0.760869565 0.659090909 0.601544402 kegg kegg NA NA no no no no no no Tyrosine metabolism Histidine metabolism 0.573913043 0 0.578893179 kegg kegg NA NA no no no no no no Tyrosine metabolism Pentose and glucuronate interconversions 0.782608696 0.75 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Primary bile acid biosynthesis 0.788695652 0.66798419 0.614929215 kegg kegg NA NA no no no no no no Tyrosine metabolism Pyrimidine metabolism 0.644347826 0.789525692 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Steroid biosynthesis 0 0.802371542 0.56988417 kegg kegg NA NA no no no no no no Tyrosine metabolism Steroid hormone biosynthesis 0.689565217 0.901185771 0 kegg kegg NA NA no no no no no no Tyrosine metabolism Synthesis and degradation of ketone bodies 0.643478261 0.791501976 0.575804376 kegg kegg NA NA no no no no no no Tyrosine metabolism Ubiquinone and other terpenoid-quinone biosynthesis 0.743478261 0.839920949 0.621106821 kegg kegg NA NA no no no no no no Tyrosine metabolism "Valine, leucine and isoleucine degradation" 0.776521739 0.862648221 0.738223938 kegg kegg NA NA no no no no no no UA+clinic 13-HODE+blood 0 0.642857143 0 clinic serum_ARA 0.855 0.32 no no no no no no UA+clinic 16:0-LPC+blood 0.479876161 0 0 clinic serum_phospholipids 0.855 0.00456 no no no up up no UA+clinic 16:0/18:2-PC+blood 0 0.6 0 clinic serum_phospholipids 0.855 3.24E-06 no no no no up up UA+clinic 16:1/16:0-PC+blood 0 0.542857143 0 clinic serum_phospholipids 0.855 0.0215 no no no no up up UA+clinic 16:1+blood 0 0 0.469230769 yes clinic serum_fattyacid 0.855 0.0186 no no no no no dn UA+clinic 18:0/16:0-PC+blood 0 0.535714286 0 clinic serum_phospholipids 0.855 9.64E-07 no no no up up up UA+clinic 18:1-LPE+blood 0 0 -0.451538462 clinic serum_phospholipids 0.855 0.117 no no no no no no UA+clinic 18:1/16:0-PC+blood 0 0.614285714 0 clinic serum_phospholipids 0.855 2.43E-05 no no no no up up UA+clinic 18:1/18:2-PI+blood 0 0 -0.426923077 clinic serum_phospholipids 0.855 0.0164 no no no dn no up UA+clinic 18:3n6+blood 0 -0.764285714 0 clinic serum_fattyacid 0.855 0.0463 no no no up no dn UA+clinic 20:1-LPA+blood 0 0 -0.449230769 clinic serum_phospholipids 0.855 0.0187 no no no dn dn no UA+clinic 4-hydroxybenzoic acid+stool 0 0 -0.459062676 clinic stool_cometabolism 0.855 0.0536 no no no no dn no UA+clinic 4-hydroxybenzoic acid+urine 0 0.754901961 0 clinic urine_cometabolism 0.855 0.52 no no no no no no UA+clinic ACA+blood 0 -0.516670556 0 clinic serum_bileacids 0.855 0.338 no no no no no no UA+clinic AGE-RAGE signaling pathway in diabetic complications 0.43083004 0 0 clinic kegg 0.855 NA no no no no no no UA+clinic Alcoholism -0.509881423 0 0 clinic kegg 0.855 NA no no no no no no UA+clinic Axon guidance -0.442123094 0 0 clinic kegg 0.855 NA no no no no up up UA+clinic Chemokine signaling pathway -0.4432524 0 0 clinic kegg 0.855 NA no no no no no no UA+clinic Collinsella 0.418581678 0 0 clinic Genus 0.855 0.128 no no no no no no UA+clinic Colorectal cancer 0 -0.545454545 0 clinic kegg 0.855 NA no no no no no no UA+clinic Creatinine+blood 0.529411765 0 0 clinic serum_choline 0.855 0.437 no no no no no no UA+clinic Cystine+blood 0 0.542857143 0 yes clinic serum_aminoacids 0.855 0.00028 no no no up up no UA+clinic Cytosolic DNA-sensing pathway -0.61038961 0 0 clinic kegg 0.855 NA no no no no no no UA+clinic d18:1-20:0-SM+blood 0 0 -0.409230769 clinic serum_phospholipids 0.855 0.933 no no no no no no UA+clinic d18:1-22:0-SM+blood -0.512899897 0 0 clinic serum_phospholipids 0.855 0.522 no no no no no no UA+clinic d18:1-22:1-SM+blood -0.488132095 0 0 clinic serum_phospholipids 0.855 0.222 no no no no no no UA+clinic Dorea 0 0 -0.506901003 clinic Genus 0.855 0.00362 no no no up no dn UA+clinic Endocrine resistance 0 -0.449350649 0 clinic kegg 0.855 NA no no no no no no UA+clinic Epstein-Barr virus infection -0.460191982 0 0 clinic kegg 0.855 NA no no no no no no UA+clinic FGF basic -0.582417582 0 0 clinic serum_cytokines 0.855 0.65 no no no no no no UA+clinic Glycine+blood 0 0.621428571 0 clinic serum_aminoacids 0.855 0.00408 no no no dn no up UA+clinic Hematopoietic cell lineage 0.509881423 0 0 clinic kegg 0.855 NA no no no no no no UA+clinic Herpes simplex virus 1 infection -0.472614342 0 0 clinic kegg 0.855 NA no no no no no no UA+clinic Human cytomegalovirus infection -0.541501976 0 0 clinic kegg 0.855 NA no no no no no dn UA+clinic Human immunodeficiency virus 1 infection -0.485036702 0 0 clinic kegg 0.855 NA no no no no no no UA+clinic Human T-cell leukemia virus 1 infection -0.46809712 0 0 clinic kegg 0.855 NA no no no no no no UA+clinic IP-10 0.763736264 0 0 clinic serum_cytokines 0.855 0.394 no no no no no no UA+clinic L-Glutamine+blood 0 0.571428571 0 clinic serum_aminoacids 0.855 0.639 no no no no no no UA+clinic L-Isoleucine+blood 0.581011352 0 0 yes clinic serum_aminoacids 0.855 5.47E-06 no no no up up no UA+clinic L-Leucine+blood 0.512899897 0 0 yes clinic serum_aminoacids 0.855 3.22E-05 no no no up up no UA+clinic L-Lysine+blood 0 0.528571429 0 yes clinic serum_aminoacids 0.855 0.0107 no no no no up no UA+clinic L-Phenylalanine+urine 0 -0.602941176 0 clinic urine_cometabolism 0.855 0.0908 no no no no up no UA+clinic L-Threonine+blood 0 0.542857143 0 clinic serum_aminoacids 0.855 0.0538 no no no dn no up UA+clinic L-Tryptophan+blood 0.512899897 0 0 clinic serum_aminoacids 0.855 0.164 no no no no no no UA+clinic L-Tryptophan+urine 0 -0.495098039 0 clinic urine_cometabolism 0.855 0.226 no no no no no no UA+clinic L-Tyrosine+urine 0 -0.56372549 0 clinic urine_cometabolism 0.855 0.45 no no no no no no UA+clinic Longevity regulating pathway - multiple species 0 0 0.448739496 clinic kegg 0.855 NA no no no no no no UA+clinic MUFA%+blood 0 0.685714286 0 clinic serum_fattyacid 0.855 0.00142 no no no up no dn UA+clinic Neurotrophin signaling pathway -0.436476567 0 0 clinic kegg 0.855 NA no no no no no no UA+clinic Phosphatidylinositol signaling system 0 -0.561038961 0 clinic kegg 0.855 NA no no no no no no UA+clinic Prevotella 0 -0.4894446 0 acetate-producing clinic Genus 0.855 0.287 no no no no no no UA+clinic Proteasome 0 0 0.423809524 clinic kegg 0.855 NA no no no no no no UA+clinic PUFA%+blood 0 0.610714286 0 clinic serum_fattyacid 0.855 0.0013 no no no dn no up UA+clinic RANTES 0.802197802 0 0 yes clinic serum_cytokines 0.855 0.0757 no no no no no up UA+clinic Serine+blood 0 0.6 0 clinic serum_aminoacids 0.855 0.942 no no no no no no UA+clinic SFA%+blood 0 0.628571429 0 clinic serum_fattyacid 0.855 0.0236 no no no no up no UA+clinic Taurine+blood 0 0.6 0 clinic serum_aminoacids 0.855 0.857 no no no no no no UA+clinic TDCA+blood 0 -0.601719207 0 yes clinic serum_bileacids 0.855 0.155 no no no no up no UA+clinic UDCA+blood 0 0 0.441619317 yes clinic serum_bileacids 0.855 0.0939 no no no no no dn UA+clinic UFA%+blood 0 0.696428571 0 clinic serum_fattyacid 0.855 0.0236 no no no no dn no UA+clinic Valine+blood 0.535603715 0 0 yes clinic serum_aminoacids 0.855 1.22E-06 no no no up up no Ubiquinone and other terpenoid-quinone biosynthesis Ascorbate and aldarate metabolism 0.686956522 0.580039526 0.631402831 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Citrate cycle (TCA cycle) 0.773913043 0.840909091 0.712226512 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Fatty acid biosynthesis 0 -0.429841897 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Fatty acid degradation 0.408695652 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Fatty acid elongation 0.66173913 0.559288538 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Fructose and mannose metabolism 0.572173913 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Galactose metabolism 0.635652174 0 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Glycolysis / Gluconeogenesis 0.595652174 0.460474308 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Pentose and glucuronate interconversions 0.730434783 0.788537549 0.488288288 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Pentose phosphate pathway 0 -0.448616601 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Primary bile acid biosynthesis 0.890434783 0.605731225 0 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Steroid biosynthesis 0 0.748023715 0.590990991 kegg kegg NA NA no no no no no no Ubiquinone and other terpenoid-quinone biosynthesis Synthesis and degradation of ketone bodies 0.780869565 0.856719368 0.724066924 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis ABC transporters -0.41826087 0 0 kegg kegg NA NA no no no no up up Ubiquitin mediated proteolysis "Alanine, aspartate and glutamate metabolism" -0.55826087 -0.488142292 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis alpha-Linolenic acid metabolism -0.476521739 -0.599802372 -0.466666667 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Amino sugar and nucleotide sugar metabolism -0.455652174 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Arginine and proline metabolism -0.522608696 -0.62055336 0 kegg kegg NA NA no no no no up no Ubiquitin mediated proteolysis Arginine biosynthesis -0.603478261 -0.457509881 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis beta-Alanine metabolism -0.49826087 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Biosynthesis of amino acids -0.60173913 -0.657114625 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Biosynthesis of cofactors 0 0.58201581 0.551351351 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Biosynthesis of unsaturated fatty acids -0.515652174 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Calcium signaling pathway 0.556521739 0.645256917 0 kegg kegg NA NA no no no no up up Ubiquitin mediated proteolysis cAMP signaling pathway 0.531304348 0 0 yes kegg kegg NA NA no no no no up up Ubiquitin mediated proteolysis Carbon metabolism -0.470434783 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Cell cycle 0 0.447628458 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis cGMP-PKG signaling pathway 0 -0.691699605 -0.465637066 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Chemokine signaling pathway 0 -0.467391304 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Cytokine-cytokine receptor interaction 0 -0.500988142 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis EGFR tyrosine kinase inhibitor resistance 0.52173913 0.580039526 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Endocrine resistance 0.519130435 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis ErbB signaling pathway 0 0 -0.569111969 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Ether lipid metabolism 0.659130435 0.496047431 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Fatty acid biosynthesis -0.676521739 -0.62055336 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Fatty acid degradation -0.824347826 -0.646245059 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Fatty acid elongation -0.49826087 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Fatty acid metabolism -0.846956522 -0.698616601 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis FoxO signaling pathway -0.51826087 -0.57312253 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Galactose metabolism -0.586086957 -0.711462451 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Glutathione metabolism 0.439130435 0.707509881 0.597683398 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Glycerolipid metabolism 0 -0.431818182 -0.434234234 kegg kegg NA NA no no no no no up Ubiquitin mediated proteolysis "Glycine, serine and threonine metabolism" 0.413043478 0.652173913 0.545688546 kegg kegg NA NA no no no no up no Ubiquitin mediated proteolysis Glycolysis / Gluconeogenesis -0.446956522 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.540513834 -0.458429858 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.415958816 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Glycosaminoglycan biosynthesis - keratan sulfate 0.559130435 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Glycosaminoglycan degradation 0 -0.571146245 -0.587644788 kegg kegg NA NA no no no no no up Ubiquitin mediated proteolysis Glyoxylate and dicarboxylate metabolism -0.640869565 -0.483201581 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis HIF-1 signaling pathway 0 0.496047431 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Histidine metabolism -0.452173913 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Inositol phosphate metabolism 0 0 -0.425997426 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Mannose type O-glycan biosynthesis 0.509565217 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis MAPK signaling pathway -0.425217391 -0.468379447 -0.474903475 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis mRNA surveillance pathway 0.587826087 0.613636364 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis N-Glycan biosynthesis 0 0.425889328 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Neuroactive ligand-receptor interaction -0.540869565 -0.705533597 0 kegg kegg NA NA no no no up up up Ubiquitin mediated proteolysis NF-kappa B signaling pathway -0.46173913 -0.462450593 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Nicotinate and nicotinamide metabolism -0.655652174 -0.635375494 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Nitrogen metabolism -0.410434783 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Non-homologous end-joining -0.492173913 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Other glycan degradation 0 0 -0.583011583 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Oxidative phosphorylation 0.487826087 0.808300395 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Pantothenate and CoA biosynthesis -0.748695652 -0.709486166 0 kegg kegg NA NA no no no no no dn Ubiquitin mediated proteolysis Pentose phosphate pathway 0 -0.716403162 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Porphyrin and chlorophyll metabolism 0.42 0.701581028 0.636036036 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis PPAR signaling pathway 0 -0.514822134 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Protein export 0.463478261 0.56027668 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Purine metabolism 0.469565217 0.696640316 0.804118404 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Pyrimidine metabolism -0.486086957 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Pyruvate metabolism 0 0.46541502 0.435006435 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Retinol metabolism -0.550434783 0 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Ribosome 0.794782609 0.750988142 0.563191763 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis RNA degradation 0.579130435 0.530632411 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis RNA polymerase 0 0.588932806 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis RNA transport 0 0.467391304 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Ruminococcus 0.450434783 0 0 acetate-producing kegg Genus NA 0.335 no no no no no no Ubiquitin mediated proteolysis Sphingolipid metabolism 0 0 -0.541312741 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Sphingolipid signaling pathway 0 -0.491106719 -0.684684685 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Starch and sucrose metabolism -0.622608696 -0.691699605 0 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Sulfur metabolism 0 0 0.50965251 kegg kegg NA NA no no no no no no Ubiquitin mediated proteolysis Thiamine metabolism 0 0.429841897 0 kegg kegg NA NA no no no no no no UDCA+blood 12-ketoDCA+blood 0.46479835 0 0 yes serum_bileacids serum_bileacids 0.0939 0.517 no no dn no no no UDCA+blood 14:0-LPC+blood 0.4776232 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.00689 no no dn up up no UDCA+blood 16:0/16:1-PI+blood 0.509214026 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.262 no no dn no no no UDCA+blood 16:0/18:0-PC+blood -0.567882703 0 -0.530822696 yes serum_bileacids serum_phospholipids 0.0939 0.521 no no dn no no no UDCA+blood 16:0/18:0-PS+blood -0.488153476 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.377 no no dn no no no UDCA+blood 16:0/18:1-PC+blood -0.525009439 0 0 yes serum_bileacids serum_phospholipids 0.0939 6.15E-07 no no dn up up up UDCA+blood 16:0/20:3-PC+blood 0 0.489270478 0 yes serum_bileacids serum_phospholipids 0.0939 5.43E-06 no no dn no up up UDCA+blood 16:0/20:5-PG+blood -0.4716059 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.00656 no no dn no up no UDCA+blood 16:0/22:6-PC+blood -0.497179426 0 0 yes serum_bileacids serum_phospholipids 0.0939 4.53E-05 no no dn no up up UDCA+blood 16:1-LPC+blood 0 -0.534641425 0 yes serum_bileacids serum_phospholipids 0.0939 0.0241 no no dn no up no UDCA+blood 16:1/16:0-PC+blood -0.522752952 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.0215 no no dn no up up UDCA+blood 16:1/16:1-PC+blood -0.663407343 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.0177 no no dn no no up UDCA+blood 16:1/18:1-PG+blood -0.528770252 0 0 yes serum_bileacids serum_phospholipids 0.0939 3.21E-05 no no dn no up up UDCA+blood 16:1/18:2-PG+blood -0.513727001 0 0 yes serum_bileacids serum_phospholipids 0.0939 1.40E-08 no no dn no up up UDCA+blood 18:0/16:0-PC+blood -0.558856753 0 0 yes serum_bileacids serum_phospholipids 0.0939 9.64E-07 no no dn up up up UDCA+blood 18:0/18:0-PC+blood 0 0.526057732 -0.573288512 yes serum_bileacids serum_phospholipids 0.0939 0.426 no no dn no no no UDCA+blood 18:0/18:0-PS+blood -0.602482179 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.00617 no no dn no up no UDCA+blood 18:0/18:1-PC+blood 0 0.575107404 -0.59452142 yes serum_bileacids serum_phospholipids 0.0939 0.393 no no dn no no no UDCA+blood 18:0/18:2-PC+blood -0.478375363 0 0 yes serum_bileacids serum_phospholipids 0.0939 1.74E-06 no no dn no up up UDCA+blood 18:0/20:2-PC+blood 0 0 -0.480822623 yes serum_bileacids serum_phospholipids 0.0939 0.733 no no dn no no no UDCA+blood 18:0/20:4-PC+blood -0.500940239 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.454 no no dn no no no UDCA+blood 18:0/20:4-PI+blood -0.525761602 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.167 no no dn no no no UDCA+blood 18:0/22:6-PA+blood -0.631816517 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.22 no no dn no no no UDCA+blood 18:1-LPE+blood 0.461075625 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.117 no no dn no no no UDCA+blood 18:1/18:0-PC+blood -0.473862388 0 0 yes serum_bileacids serum_phospholipids 0.0939 1.83E-06 no no dn no up up UDCA+blood 18:1/18:0-PS+blood -0.730349807 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.193 no no dn no no no UDCA+blood 18:1/18:1-PG+blood -0.4595713 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.00352 no no dn no up up UDCA+blood 18:1/18:2-PG+blood -0.518992139 0 0 yes serum_bileacids serum_phospholipids 0.0939 5.58E-07 no no dn no up up UDCA+blood 18:1/20:4-PE+blood -0.508461864 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.0578 no no dn up no no UDCA+blood 18:2-LPA+blood 0 -0.526057732 0 yes serum_bileacids serum_phospholipids 0.0939 0.00684 no no dn dn no up UDCA+blood 18:3-LPC+blood 0.639338142 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.147 no no dn no no no UDCA+blood 20:0/20:5-PC+blood -0.634073005 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.882 no no dn no no no UDCA+blood 20:1-LPC+blood 0 0 -0.406849912 yes serum_bileacids serum_phospholipids 0.0939 0.217 no no dn no no no UDCA+blood 20:1/20:4-PE+blood -0.543813502 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.0042 no no dn up up no UDCA+blood 20:2+blood 0 0 -0.57157618 yes serum_bileacids serum_fattyacid 0.0939 0.478 no no dn no no no UDCA+blood 20:3/18:0-PC+blood -0.561865403 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.296 no no dn no no no UDCA+blood 20:3/18:0-PI+blood -0.495675101 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.289 no no dn no no no UDCA+blood 20:4-LPA+blood -0.4776232 0 -0.452397924 yes serum_bileacids serum_phospholipids 0.0939 0.398 no no dn no no no UDCA+blood 20:4/18:0-PE+blood -0.594960554 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.000755 no no dn up up no UDCA+blood 24:0+blood 0 0 0.417808832 yes serum_bileacids serum_fattyacid 0.0939 0.034 no no dn dn no up UDCA+blood AA+blood -0.504701051 0 0 yes serum_bileacids serum_ARA 0.0939 0.212 no no dn no no no UDCA+blood acetic acid C2+blood -0.510718351 0 0 yes serum_bileacids serum_scfa 0.0939 0.000193 no no dn up dn no UDCA+blood Acute myeloid leukemia 0 -0.637233432 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood AGE-RAGE signaling pathway in diabetic complications 0 -0.737307043 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Aldosterone synthesis and secretion 0 0.575423261 0 yes serum_bileacids kegg 0.0939 NA no no dn no up up UDCA+blood Alzheimer disease 0 0.649006798 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Amoebiasis 0 -0.610743359 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Amphetamine addiction 0 0.619573383 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Amyotrophic lateral sclerosis 0 0.707873628 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Anaerostipes 0 0.528576353 0 yes butyrate-producing serum_bileacids Genus 0.0939 0.568 no no dn no no no UDCA+blood Apelin signaling pathway 0 0.656365152 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Apoptosis 0 -0.528329797 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Arginine and proline metabolism 0 -0.769683799 0 yes serum_bileacids kegg 0.0939 NA no no dn no up no UDCA+blood Autophagy - animal 0 -0.631346749 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood B cell receptor signaling pathway 0 -0.540103163 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Biosynthesis of amino acids 0 -0.634290091 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Bladder cancer 0 -0.721118665 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Breast cancer 0 -0.526858126 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood C-type lectin receptor signaling pathway 0 -0.578366602 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood CA+blood 0.616629044 0.487730061 0.529210403 yes serum_bileacids serum_bileacids 0.0939 0.606 no no dn no no no UDCA+blood Cardiac muscle contraction 0 0.643120115 0 yes serum_bileacids kegg 0.0939 NA no no dn no no up UDCA+blood CDCA+blood 0.843174185 0.78356851 0.711987345 yes serum_bileacids serum_bileacids 0.0939 0.506 no no dn no no no UDCA+blood Cell cycle 0 0.582781615 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood cGMP-PKG signaling pathway 0 -0.678440213 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Chagas disease 0 -0.551876529 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Chemokine signaling pathway 0 -0.51361309 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Coronavirus disease - COVID-19 0 0.644591786 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood d18:1-18:0-SM+blood -0.563369728 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.97 no no dn no no no UDCA+blood d18:1-18:1-SM+blood -0.528770252 0 0 yes serum_bileacids serum_phospholipids 0.0939 0.916 no no dn no no no UDCA+blood DCA+blood 0.73110197 0 0.462329445 yes serum_bileacids serum_bileacids 0.0939 0.122 no no dn no no no UDCA+blood Diabetic cardiomyopathy 0 0.634290091 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood EGFR tyrosine kinase inhibitor resistance 0 0.616630042 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Epithelial cell signaling in Helicobacter pylori infection 0 -0.707873628 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Fc epsilon RI signaling pathway 0 -0.788815519 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Fc gamma R-mediated phagocytosis 0 -0.744665397 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood GABAergic synapse 0 -0.75055208 0 yes serum_bileacids kegg 0.0939 NA no no dn no up up UDCA+blood GCA+blood 0.518239976 0 0 yes yes serum_bileacids serum_bileacids 0.0939 0.16 no no dn no no no UDCA+blood GCDCA+blood 0.661903018 0 0 yes serum_bileacids serum_bileacids 0.0939 0.31 no no dn no no no UDCA+blood Glucagon signaling pathway 0 0.681383555 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Glutamatergic synapse 0 -0.631346749 0 yes serum_bileacids kegg 0.0939 NA no no dn no up up UDCA+blood Glycine+blood 0 -0.543225117 0 yes serum_bileacids serum_aminoacids 0.0939 0.00408 no no dn dn no up UDCA+blood Glycolysis / Gluconeogenesis 0 0.501839724 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood GPC+blood 0 0 -0.414384169 yes serum_bileacids serum_choline 0.0939 0.00427 no no dn no up up UDCA+blood GUDCA+blood 0.748401708 0.72225642 0.553425469 yes serum_bileacids serum_bileacids 0.0939 0.0766 no no dn no no dn UDCA+blood HCA+blood 0.703565162 0.552757022 0.494849777 yes serum_bileacids serum_bileacids 0.0939 0.544 no no dn no no no UDCA+blood HCA+stool 0 0 0.507928145 yes serum_bileacids stool_bileacids 0.0939 0.155 no no dn no no no UDCA+blood Hepatitis B 0 -0.621045054 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood HIF-1 signaling pathway 0 0.629875079 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Hippo signaling pathway 0 0.540103163 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Huntington disease 0 0.65342181 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood IL-17 signaling pathway 0 -0.693156921 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Inflammatory mediator regulation of TRP channels 0 0.63281842 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Insulin signaling pathway 0 0.687270238 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Intestinal immune network for IgA production 0 0 -0.401847694 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood iso-LCA+stool 0 0 -0.458116469 yes serum_bileacids stool_bileacids 0.0939 0.72 no no dn no no no UDCA+blood isovaleric acid iso-C5+blood 0 0 -0.449315727 yes serum_bileacids serum_scfa 0.0939 0.117 no no dn no no no UDCA+blood L-Phenylalanine+stool 0 -0.76993366 0 yes serum_bileacids stool_cometabolism 0.0939 0.398 no no dn no no no UDCA+blood L-Tryptophan+stool -0.572215122 0 0 yes serum_bileacids stool_cometabolism 0.0939 0.557 no no dn no no no UDCA+blood L-Tyrosine+stool 0 -0.779045301 0 yes serum_bileacids stool_cometabolism 0.0939 0.44 no no dn no no no UDCA+blood Lipid and atherosclerosis 0 -0.676968542 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Long-term potentiation 0 0.545989846 0 yes serum_bileacids kegg 0.0939 NA no no dn no no up UDCA+blood Lysosome 0 -0.598969993 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Melanogenesis 0 0.61221503 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood mRNA surveillance pathway 0 0.604856676 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood mTOR signaling pathway 0 0.581309944 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Neuroactive ligand-receptor interaction 0 -0.537159822 0 yes serum_bileacids kegg 0.0939 NA no no dn up up up UDCA+blood Neutrophil extracellular trap formation 0 -0.679911884 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood NF-kappa B signaling pathway 0 -0.545989846 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Nicotinate and nicotinamide metabolism 0 -0.822663946 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood NOD-like receptor signaling pathway 0 -0.638705103 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Non-alcoholic fatty liver disease 0 0.556291541 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood nutriCA+blood 0.66722259 0.662335497 0.533796474 yes serum_bileacids serum_bileacids 0.0939 0.726 no no dn no no no UDCA+blood nutriCA+stool 0 0 0.483777029 yes serum_bileacids stool_bileacids 0.0939 0.481 no no dn no no no UDCA+blood Olfactory transduction 0 -0.654893481 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Oocyte meiosis 0 0.582781615 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Osteoclast differentiation 0 -0.694628591 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Oxidative phosphorylation 0 0.628403408 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Parabacteroides -0.4655886 0 0 yes serum_bileacids Genus 0.0939 4.19E-05 no no dn no up up UDCA+blood Parkinson disease 0 0.565121566 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Pathways of neurodegeneration - multiple diseases 0 0.565121566 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Peroxisome 0 -0.665195176 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Pertussis 0 -0.625460066 0 yes serum_bileacids kegg 0.0939 NA no no dn no no dn UDCA+blood Phenylacetic acid+stool 0 -0.633259046 0 yes serum_bileacids stool_cometabolism 0.0939 0.785 no no dn no no no UDCA+blood Phospholipase D signaling pathway 0 -0.682855225 0 yes serum_bileacids kegg 0.0939 NA no no dn no up up UDCA+blood PPAR signaling pathway 0 -0.727005348 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Prion disease 0 0.65195014 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Prolactin signaling pathway 0 -0.678440213 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Proteasome 0 0.525386456 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Protein processing in endoplasmic reticulum 0 0.699043604 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Proteoglycans in cancer 0 0.619573383 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Ras signaling pathway 0 0.547461517 0 yes yes serum_bileacids kegg 0.0939 NA no no dn no up up UDCA+blood Renin secretion 0 0.634290091 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Retrograde endocannabinoid signaling 0 0.616630042 0 yes serum_bileacids kegg 0.0939 NA no no dn no no up UDCA+blood Rheumatoid arthritis 0 -0.500368053 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Ribosome 0 0.644591786 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Ribosome biogenesis in eukaryotes 0 0.615158371 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood RIG-I-like receptor signaling pathway 0 -0.566593237 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood RNA degradation 0 0.813833922 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood RNA transport 0 0.579838273 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Sphingolipid signaling pathway 0 -0.520971443 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Spinocerebellar ataxia 0 0.622516725 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Staphylococcus aureus infection 0 -0.5533482 0 yes serum_bileacids kegg 0.0939 NA no no dn up no no UDCA+blood Systemic lupus erythematosus 0 -0.575423261 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood T-a-MCA+blood 0 0 -0.417123849 yes serum_bileacids serum_bileacids 0.0939 0.478 no no dn no no no UDCA+blood Thermogenesis 0 0.662251835 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Toll-like receptor signaling pathway 0 -0.678440213 0 yes yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Transcriptional misregulation in cancer 0 -0.520971443 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Tuberculosis 0 -0.619573383 0 yes serum_bileacids kegg 0.0939 NA no no dn no no dn UDCA+blood Ubiquitin mediated proteolysis 0 0.538631492 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood UDCA+stool 0 0 0.564532321 yes serum_bileacids stool_bileacids 0.0939 0.266 no no dn no no no UDCA+blood Wnt signaling pathway 0 0.681383555 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+blood Yersinia infection 0 -0.563649895 0 yes serum_bileacids kegg 0.0939 NA no no dn no no no UDCA+stool 3-(3-Hydroxyphenyl)propanoic acid+stool 0 0 0.432806324 stool_bileacids stool_cometabolism 0.266 0.33 no no no no no no UDCA+stool 5-Hydroxytryptamine+stool 0 -0.615384615 0 stool_bileacids stool_cometabolism 0.266 0.00862 no no no dn dn no UDCA+stool Adipocytokine signaling pathway 0 0 -0.526821005 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Allograft rejection 0 0.690909091 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Alzheimer disease 0 0 0.607001694 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool AMPK signaling pathway 0 0 -0.602484472 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Amyotrophic lateral sclerosis 0 0 0.613777527 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Antigen processing and presentation 0.51496388 0.636363636 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Autoimmune thyroid disease 0 0.690909091 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Bacteroides 0.471620227 0 0 LPS-producing stool_bileacids Genus 0.266 0.000267 no no no dn dn up UDCA+stool Blautia 0 0.832167832 0 acetate-producing stool_bileacids Genus 0.266 1.36E-05 no no no up dn dn UDCA+stool CA+stool 0.651186791 0.86013986 0.751976285 stool_bileacids stool_bileacids 0.266 0.827 no no no no no no UDCA+stool Carbon metabolism 0 0.672727273 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Cardiac muscle contraction 0 0 0.63297572 stool_bileacids kegg 0.266 NA no no no no no up UDCA+stool CDCA+stool 0.750257998 0.909090909 0.801383399 stool_bileacids stool_bileacids 0.266 0.663 no no no no no no UDCA+stool Cell adhesion molecules 0 0.654545455 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Cellular senescence 0 0.627272727 0.425183512 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Chemical carcinogenesis - receptor activation 0 -0.709090909 -0.445511011 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Clostridium 0 0.601398601 0 stool_bileacids Genus 0.266 0.925 no no no no no no UDCA+stool Cocaine addiction 0 -0.663636364 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Coronavirus disease - COVID-19 -0.479876161 0 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Cortisol synthesis and secretion 0 -0.718181818 0 stool_bileacids kegg 0.266 NA no no no no no up UDCA+stool Cushing syndrome -0.539731682 0 0 stool_bileacids kegg 0.266 NA no no no no no up UDCA+stool Diabetic cardiomyopathy 0 0 0.584415584 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Dorea 0 0.79020979 0 stool_bileacids Genus 0.266 0.00362 no no no up no dn UDCA+stool Endocrine resistance 0 -0.781818182 -0.508752117 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Epithelial cell signaling in Helicobacter pylori infection 0.5500516 0 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Epstein-Barr virus infection 0.490196078 0 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool FoxO signaling pathway 0 0 -0.461321287 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool GABAergic synapse 0 0 -0.428571429 stool_bileacids kegg 0.266 NA no no no no up up UDCA+stool Gap junction 0 -0.672727273 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool GCA+stool 0 0.846153846 0 stool_bileacids stool_bileacids 0.266 0.0809 no no no no no no UDCA+stool GCDCA+stool 0 0.685314685 0 yes stool_bileacids stool_bileacids 0.266 0.0471 no no no no dn no UDCA+stool GDCA+stool 0 0.756568586 0 stool_bileacids stool_bileacids 0.266 0.656 no no no no no no UDCA+stool Glutamatergic synapse 0 -0.654545455 -0.445511011 stool_bileacids kegg 0.266 NA no no no no up up UDCA+stool GnRH signaling pathway 0 -0.718181818 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Graft-versus-host disease 0 0.690909091 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool "Growth hormone synthesis, secretion and action" 0 -0.763636364 -0.422924901 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool HCA+stool 0.834881321 0 0.624505929 stool_bileacids stool_bileacids 0.266 0.155 no no no no no no UDCA+stool Hepatitis C 0 0 -0.425183512 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Hepatocellular carcinoma 0 0 0.440993789 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Herpes simplex virus 1 infection 0 0.654545455 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Human T-cell leukemia virus 1 infection 0 0.609090909 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Huntington disease 0 0 0.543760587 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool IL-17 signaling pathway 0.475748194 0 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Indole-3-Acetic acid+stool 0 -0.755244755 0 stool_bileacids stool_cometabolism 0.266 0.304 no no no no no no UDCA+stool Insulin secretion 0 -0.609090909 0 yes stool_bileacids kegg 0.266 NA no no no no up up UDCA+stool iso-DCA+stool -0.572755418 0 0 stool_bileacids stool_bileacids 0.266 0.155 no no no no no no UDCA+stool iso-LCA+stool -0.658750733 -0.629370629 -0.726284585 stool_bileacids stool_bileacids 0.266 0.72 no no no no no no UDCA+stool Isobutyric acid+stool 0 -0.776223776 -0.468379447 stool_bileacids stool_scfa 0.266 0.408 no no no no no no UDCA+stool Isovaleric acid+stool 0 -0.636363636 -0.479249012 stool_bileacids stool_scfa 0.266 0.343 no no no no no no UDCA+stool Kynurenic acid+stool -0.609907121 0 -0.431818182 stool_bileacids stool_cometabolism 0.266 0.037 no no no dn dn no UDCA+stool L-Phenylalanine+stool 0 0 -0.493083004 stool_bileacids stool_cometabolism 0.266 0.398 no no no no no no UDCA+stool L-Tyrosine+stool 0 0 -0.482213439 stool_bileacids stool_cometabolism 0.266 0.44 no no no no no no UDCA+stool LCA+stool 0 -0.601398601 -0.442687747 stool_bileacids stool_bileacids 0.266 0.314 no no no no no no UDCA+stool Lipid and atherosclerosis 0.502579979 0 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Longevity regulating pathway 0 -0.681818182 -0.531338227 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Lysosome 0.512899897 0 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Malaria 0 0 -0.446640316 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Mitophagy - animal 0 0 -0.442123094 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Natural killer cell mediated cytotoxicity 0 0.627272727 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Neutrophil extracellular trap formation 0.488132095 0 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Non-alcoholic fatty liver disease 0 0 0.454545455 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool nutriCA+stool 0.857585139 0.64790339 0.867588933 stool_bileacids stool_bileacids 0.266 0.481 no no no no no no UDCA+stool Oxidative phosphorylation 0 0 0.574251835 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool p53 signaling pathway 0 -0.618181818 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Pathways in cancer 0 0 -0.511010728 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Pertussis 0.760577915 0 0 stool_bileacids kegg 0.266 NA no no no no no dn UDCA+stool Phenylacetic acid+stool 0 0 -0.434782609 stool_bileacids stool_cometabolism 0.266 0.785 no no no no no no UDCA+stool Prion disease 0 0 0.561829475 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Proteasome 0 0.745454545 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Proteoglycans in cancer 0 0 0.450028233 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Purine metabolism 0 0 -0.497459063 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Regulation of actin cytoskeleton 0 0 0.472614342 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Regulation of lipolysis in adipocytes 0 -0.609090909 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Retrograde endocannabinoid signaling 0 0 0.679277244 stool_bileacids kegg 0.266 NA no no no no no up UDCA+stool Ribosome -0.475748194 0 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Salmonella infection 0 0.636363636 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Serotonergic synapse 0 -0.836363636 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Signaling pathways regulating pluripotency of stem cells -0.539731682 0 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Staphylococcus aureus infection 0.521155831 0 0 stool_bileacids kegg 0.266 NA no no no up no no UDCA+stool Systemic lupus erythematosus 0.523219814 0 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool T-¦Á-MCA+stool 0 -0.715957986 0 stool_bileacids stool_bileacids 0.266 0.48 no no no no no no UDCA+stool TDCA+stool 0 0 0.468993666 stool_bileacids stool_bileacids 0.266 0.963 no no no no no no UDCA+stool Thermogenesis 0 0 0.520045172 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Thyroid hormone signaling pathway 0 0 0.43308865 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool TUDCA+stool 0 0 -0.715916838 stool_bileacids stool_bileacids 0.266 0.241 no no no no no no UDCA+stool Type I diabetes mellitus 0 0.690909091 0 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Viral myocarditis 0 0.690909091 0.439864483 stool_bileacids kegg 0.266 NA no no no no no no UDCA+stool Wnt signaling pathway 0 0 0.424054207 stool_bileacids kegg 0.266 NA no no no no no no UFA%+blood 12-ketoDCA+blood -0.496889108 0 0 serum_fattyacid serum_bileacids 0.0236 0.517 no dn no no no no UFA%+blood 13-HODE+blood 0 0.507352941 0 serum_fattyacid serum_ARA 0.0236 0.32 no dn no no no no UFA%+blood 14:0/20:4-PC+blood 0 0 -0.425641026 serum_fattyacid serum_phospholipids 0.0236 0.486 no dn no no no no UFA%+blood 14:1/18:2-PG+blood 0 0 -0.433846154 serum_fattyacid serum_phospholipids 0.0236 0.00259 no dn no no up up UFA%+blood 16:0/14:0-PC+blood 0 0 0.456410256 serum_fattyacid serum_phospholipids 0.0236 0.0206 no dn no no up up UFA%+blood 16:0/16:0-PC+blood 0.464661654 0 0 serum_fattyacid serum_phospholipids 0.0236 0.00079 no dn no no up up UFA%+blood 16:0/16:0-PI+blood -0.642105263 0 -0.457094017 serum_fattyacid serum_phospholipids 0.0236 0.358 no dn no no no no UFA%+blood 16:0/16:1-PI+blood -0.783458647 0 -0.474188034 serum_fattyacid serum_phospholipids 0.0236 0.262 no dn no no no no UFA%+blood 16:0/18:1-PC+blood 0.703759398 0 0.424957265 serum_fattyacid serum_phospholipids 0.0236 6.15E-07 no dn no up up up UFA%+blood 16:0/18:1-PE+blood -0.532330827 0 0 serum_fattyacid serum_phospholipids 0.0236 0.000107 no dn no up up no UFA%+blood 16:0/18:2-PC+blood 0.706766917 0.654411765 0.634871795 serum_fattyacid serum_phospholipids 0.0236 3.24E-06 no dn no no up up UFA%+blood 16:0/18:2-PI+blood -0.566917293 0 -0.433162393 serum_fattyacid serum_phospholipids 0.0236 0.269 no dn no no no no UFA%+blood 16:0/20:3-PC+blood 0.687218045 0 0.472136752 serum_fattyacid serum_phospholipids 0.0236 5.43E-06 no dn no no up up UFA%+blood 16:0/20:4-PC+blood 0.560902256 0 0 serum_fattyacid serum_phospholipids 0.0236 0.0262 no dn no no up no UFA%+blood 16:0/20:4-PI+blood -0.729323308 0 -0.546666667 serum_fattyacid serum_phospholipids 0.0236 0.558 no dn no no no no UFA%+blood 16:0/22:0-PE+blood 0 0 0.503589744 serum_fattyacid serum_phospholipids 0.0236 0.00839 no dn no dn no up UFA%+blood 16:0/22:6-PC+blood 0.515789474 0 0.651965812 serum_fattyacid serum_phospholipids 0.0236 4.53E-05 no dn no no up up UFA%+blood 16:1/16:0-PC+blood 0.676691729 0 0.447521368 serum_fattyacid serum_phospholipids 0.0236 0.0215 no dn no no up up UFA%+blood 16:1/16:1-PC+blood 0.577443609 0 0 serum_fattyacid serum_phospholipids 0.0236 0.0177 no dn no no no up UFA%+blood 16:1/18:2-PG+blood 0.521804511 0 0 serum_fattyacid serum_phospholipids 0.0236 1.40E-08 no dn no no up up UFA%+blood 18:0-LPA+blood 0 0.669117647 0 serum_fattyacid serum_phospholipids 0.0236 0.0725 no dn no no dn no UFA%+blood 18:0/16:0-PC+blood 0.691729323 0 0.406495726 serum_fattyacid serum_phospholipids 0.0236 9.64E-07 no dn no up up up UFA%+blood 18:0/18:0-PE+blood -0.646616541 0 -0.472820513 serum_fattyacid serum_phospholipids 0.0236 0.00896 no dn no up up no UFA%+blood 18:0/18:1-PE+blood -0.679699248 0 -0.484444444 serum_fattyacid serum_phospholipids 0.0236 0.00716 no dn no up up no UFA%+blood 18:0/18:1-PG+blood 0 0 -0.673846154 serum_fattyacid serum_phospholipids 0.0236 0.000842 no dn no no up no UFA%+blood 18:0/18:2-PC+blood 0.693233083 0 0.667692308 serum_fattyacid serum_phospholipids 0.0236 1.74E-06 no dn no no up up UFA%+blood 18:0/20:4-PC+blood 0.527819549 0 0 serum_fattyacid serum_phospholipids 0.0236 0.454 no dn no no no no UFA%+blood 18:0/20:5-PC+blood 0.536842105 0 0 serum_fattyacid serum_phospholipids 0.0236 0.17 no dn no no no no UFA%+blood 18:1/16:0-PC+blood 0.697744361 0.642156863 0.651965812 serum_fattyacid serum_phospholipids 0.0236 2.43E-05 no dn no no up up UFA%+blood 18:1/16:0-PE+blood -0.640601504 0 -0.519316239 serum_fattyacid serum_phospholipids 0.0236 0.000182 no dn no up up no UFA%+blood 18:1/16:0-PI+blood -0.630075188 0 0 serum_fattyacid serum_phospholipids 0.0236 0.793 no dn no no no no UFA%+blood 18:1/16:1-PE+blood -0.583458647 0 0 serum_fattyacid serum_phospholipids 0.0236 0.000184 no dn no up up no UFA%+blood 18:1/18:0-PC+blood 0.687218045 0 0.656752137 serum_fattyacid serum_phospholipids 0.0236 1.83E-06 no dn no no up up UFA%+blood 18:1/18:0-PI+blood 0 -0.514705882 0 serum_fattyacid serum_phospholipids 0.0236 0.0931 no dn no no no up UFA%+blood 18:1/18:1-PC+blood 0.566917293 0 0.436581197 serum_fattyacid serum_phospholipids 0.0236 1.34E-05 no dn no no up up UFA%+blood 18:1/18:2-PE+blood 0 0 -0.471452991 serum_fattyacid serum_phospholipids 0.0236 0.000293 no dn no up up no UFA%+blood 18:1/18:2-PG+blood 0.503759398 0 0 serum_fattyacid serum_phospholipids 0.0236 5.58E-07 no dn no no up up UFA%+blood 18:1/20:4-PC+blood 0.467669173 0 0 serum_fattyacid serum_phospholipids 0.0236 0.582 no dn no no no no UFA%+blood 18:1/22:6-PE+blood 0 0 0.405128205 serum_fattyacid serum_phospholipids 0.0236 0.0047 no dn no no up no UFA%+blood 18:2-LPA+blood 0 0.482843137 0 serum_fattyacid serum_phospholipids 0.0236 0.00684 no dn no dn no up UFA%+blood 18:2/16:0-PC+blood 0.729323308 0 0.434529915 serum_fattyacid serum_phospholipids 0.0236 8.67E-05 no dn no no up up UFA%+blood 18:3/16:0-PE+blood -0.562406015 0 -0.655384615 serum_fattyacid serum_phospholipids 0.0236 0.00149 no dn no up up no UFA%+blood 18:3n3+blood 0.452631579 0 0 serum_fattyacid serum_fattyacid 0.0236 0.291 no dn no no no no UFA%+blood 18:3n6+blood -0.541353383 -0.50245098 -0.446153846 serum_fattyacid serum_fattyacid 0.0236 0.0463 no dn no up no dn UFA%+blood 20:0/20:4-PE+blood 0 -0.519607843 -0.456410256 serum_fattyacid serum_phospholipids 0.0236 0.00128 no dn no up up no UFA%+blood 20:1-LPA+blood 0 0.566176471 0 serum_fattyacid serum_phospholipids 0.0236 0.0187 no dn no dn dn no UFA%+blood 20:1/20:4-PC+blood 0 0 0.437948718 serum_fattyacid serum_phospholipids 0.0236 0.0419 no dn no no no up UFA%+blood 20:1/20:4-PE+blood 0 0 -0.455726496 serum_fattyacid serum_phospholipids 0.0236 0.0042 no dn no up up no UFA%+blood 20:2-LPC+blood 0 0 0.410598291 serum_fattyacid serum_phospholipids 0.0236 0.119 no dn no no no up UFA%+blood 20:2/18:1-PE+blood -0.460150376 0 0 serum_fattyacid serum_phospholipids 0.0236 0.00208 no dn no up up no UFA%+blood 20:2+blood 0 0 0.486495726 serum_fattyacid serum_fattyacid 0.0236 0.478 no dn no no no no UFA%+blood 20:3/16:0-PC+blood 0.586466165 0 0 serum_fattyacid serum_phospholipids 0.0236 0.00405 no dn no no up up UFA%+blood 20:3/18:0-PC+blood 0 0 0.497435897 serum_fattyacid serum_phospholipids 0.0236 0.296 no dn no no no no UFA%+blood 20:4-LPA+blood 0 0.519607843 0 serum_fattyacid serum_phospholipids 0.0236 0.398 no dn no no no no UFA%+blood 20:4/16:0-PE+blood -0.458646617 0 -0.498803419 serum_fattyacid serum_phospholipids 0.0236 0.00529 no dn no no up up UFA%+blood 20:5/18:0-PC+blood 0.517293233 0 0.72034188 serum_fattyacid serum_phospholipids 0.0236 3.97E-06 no dn no no up up UFA%+blood 22:0/16:0-PE+blood 0 0 0.502905983 serum_fattyacid serum_phospholipids 0.0236 0.091 no dn no no no up UFA%+blood 22:1-LPA+blood 0 0.546568627 0 serum_fattyacid serum_phospholipids 0.0236 0.00373 no dn no no up up UFA%+blood 22:6n3+blood 0 0 0.412649573 serum_fattyacid serum_fattyacid 0.0236 0.792 no dn no no no no UFA%+blood 24:1+blood 0 0 0.482393162 serum_fattyacid serum_fattyacid 0.0236 0.00582 no dn no no dn dn UFA%+blood 5-HETE+blood 0.492078975 0 0 serum_fattyacid serum_ARA 0.0236 0.697 no dn no no no no UFA%+blood AA+blood 0.533834586 0 0 serum_fattyacid serum_ARA 0.0236 0.212 no dn no no no no UFA%+blood ACA+stool 0.566955362 0 0 serum_fattyacid stool_bileacids 0.0236 0.417 no dn no no no no UFA%+blood Acetic acid+stool 0 0 -0.463157895 yes serum_fattyacid stool_scfa 0.0236 0.0656 no dn no dn no no UFA%+blood Adrenergic signaling in cardiomyocytes 0 -0.655882353 -0.44 serum_fattyacid kegg 0.0236 NA no dn no no no up UFA%+blood AGE-RAGE signaling pathway in diabetic complications 0 0.629411765 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Aldosterone synthesis and secretion 0 -0.691176471 0 serum_fattyacid kegg 0.0236 NA no dn no no up up UFA%+blood Allograft rejection 0 0.588235294 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Alzheimer disease 0 -0.591176471 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Amoebiasis 0 0.617647059 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Amphetamine addiction 0 -0.688235294 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Amyotrophic lateral sclerosis 0 -0.608823529 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Apelin signaling pathway 0 -0.685294118 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Apoptosis 0 0.6 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Autoimmune thyroid disease 0 0.588235294 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood B cell receptor signaling pathway 0.494736842 0 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Betaine+blood 0 0 0.484444444 serum_fattyacid serum_choline 0.0236 0.857 no dn no no no no UFA%+blood Biosynthesis of amino acids 0 0.702941176 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Bladder cancer 0 0.629411765 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Breast cancer 0 0 -0.443846154 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Butyricimonas 0 -0.497776273 0 butyrate-producing serum_fattyacid Genus 0.0236 0.17 no dn no no no no UFA%+blood C-type lectin receptor signaling pathway 0 0.535294118 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood CA+blood 0 -0.532188941 -0.435337038 serum_fattyacid serum_bileacids 0.0236 0.606 no dn no no no no UFA%+blood Calcium signaling pathway 0 0 -0.496923077 serum_fattyacid kegg 0.0236 NA no dn no no up up UFA%+blood capric acid C6+blood 0 0 0.532307692 serum_fattyacid serum_scfa 0.0236 0.433 no dn no no no no UFA%+blood Carbon metabolism 0 0 0.488461538 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Cardiac muscle contraction 0 -0.570588235 -0.415384615 serum_fattyacid kegg 0.0236 NA no dn no no no up UFA%+blood CDCA+blood 0 -0.556372549 0 serum_fattyacid serum_bileacids 0.0236 0.506 no dn no no no no UFA%+blood Cell adhesion molecules 0 0.620588235 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Cell cycle 0 -0.723529412 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Cellular senescence 0 0.658823529 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood cGMP-PKG signaling pathway 0 0.623529412 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Chemical carcinogenesis - receptor activation 0 -0.526470588 -0.470769231 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Chemokine signaling pathway 0 0.523529412 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Choline metabolism in cancer 0 0 -0.450769231 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Colorectal cancer 0 -0.561764706 -0.479230769 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Coronavirus disease - COVID-19 0 -0.658823529 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Cortisol synthesis and secretion 0 0 -0.498461538 serum_fattyacid kegg 0.0236 NA no dn no no no up UFA%+blood Creatinine+blood 0.535338346 0.517156863 0.516581197 serum_fattyacid serum_choline 0.0236 0.437 no dn no no no no UFA%+blood Cushing syndrome 0 -0.614705882 -0.541538462 serum_fattyacid kegg 0.0236 NA no dn no no no up UFA%+blood Cysteine+blood 0.464661654 0.644607843 0.548717949 yes serum_fattyacid serum_aminoacids 0.0236 1.81E-07 no dn no dn up up UFA%+blood Cystine+blood 0.457142857 0.700980392 0.486495726 yes serum_fattyacid serum_aminoacids 0.0236 0.00028 no dn no up up no UFA%+blood d18:1-14:0-SM+blood 0 -0.590686275 -0.433162393 serum_fattyacid serum_phospholipids 0.0236 0.94 no dn no no no no UFA%+blood d18:1-14:1-SM+blood 0 -0.585784314 -0.416752137 serum_fattyacid serum_phospholipids 0.0236 0.0952 no dn no no dn no UFA%+blood d18:1-16:1-SM+blood 0 -0.536764706 -0.474871795 serum_fattyacid serum_phospholipids 0.0236 0.2 no dn no no no no UFA%+blood d18:1-18:0-SM+blood 0.636090226 0 0 serum_fattyacid serum_phospholipids 0.0236 0.97 no dn no no no no UFA%+blood d18:1-18:1-SM+blood 0.461654135 0 0 serum_fattyacid serum_phospholipids 0.0236 0.916 no dn no no no no UFA%+blood d18:1-20:1-SM+blood 0.512781955 0 0 serum_fattyacid serum_phospholipids 0.0236 0.0992 no dn no no no no UFA%+blood DCA+stool 0 0 -0.569924812 serum_fattyacid stool_bileacids 0.0236 0.195 no dn no no no no UFA%+blood decanoic acid C10+blood 0 0 0.506324786 serum_fattyacid serum_mcfa 0.0236 6.64E-11 no dn no dn dn no UFA%+blood Diabetic cardiomyopathy 0 -0.573529412 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood DMG+blood 0 0 0.522051282 serum_fattyacid serum_choline 0.0236 0.909 no dn no no no no UFA%+blood Dopaminergic synapse 0 -0.564705882 0 serum_fattyacid kegg 0.0236 NA no dn no no up no UFA%+blood DPA+blood 0 0.522058824 0 serum_fattyacid serum_ARA 0.0236 0.519 no dn no no no no UFA%+blood EGFR tyrosine kinase inhibitor resistance 0 -0.723529412 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Endocrine resistance 0 0 -0.554615385 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Endocytosis 0 0.702941176 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Epithelial cell signaling in Helicobacter pylori infection 0.459649123 0.644117647 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood ErbB signaling pathway 0 0 -0.432307692 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Ethanolamine+blood 0 0.602941176 0 serum_fattyacid serum_aminoacids 0.0236 0.122 no dn no up no no UFA%+blood Fc epsilon RI signaling pathway 0 0.558823529 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Fc gamma R-mediated phagocytosis 0 0.7 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Fusobacterium 0 0 0.468093501 serum_fattyacid Genus 0.0236 0.628 no dn no no no no UFA%+blood Gastric cancer 0 0 -0.44 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood GCDCA+blood -0.535338346 0 0 serum_fattyacid serum_bileacids 0.0236 0.31 no dn no no no no UFA%+blood Glucagon signaling pathway 0 -0.652941176 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Glycine+blood 0.536842105 0.681372549 0.567179487 serum_fattyacid serum_aminoacids 0.0236 0.00408 no dn no dn no up UFA%+blood Graft-versus-host disease 0 0.588235294 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood "Growth hormone synthesis, secretion and action" 0 0 -0.565384615 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood GUDCA+blood -0.496240602 0 0 serum_fattyacid serum_bileacids 0.0236 0.0766 no dn no no no dn UFA%+blood HCA+blood 0 -0.49980696 0 serum_fattyacid serum_bileacids 0.0236 0.544 no dn no no no no UFA%+blood HDCA+blood 0.518101712 0 0 serum_fattyacid serum_bileacids 0.0236 0.483 no dn no no no no UFA%+blood Hepatitis B 0 0.5 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood HIF-1 signaling pathway 0 -0.591176471 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Human papillomavirus infection 0 0.611764706 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Huntington disease 0 -0.570588235 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood IL-17 signaling pathway 0 0.641176471 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Inflammatory mediator regulation of TRP channels 0 -0.594117647 -0.481538462 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Influenza A 0.610526316 0 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Insulin secretion 0 0 -0.404615385 yes serum_fattyacid kegg 0.0236 NA no dn no no up up UFA%+blood Insulin signaling pathway 0 -0.694117647 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood iso-DCA+blood 0.621052632 0 0 serum_fattyacid serum_bileacids 0.0236 0.38 no dn no no no no UFA%+blood L-Arginine+blood 0 0 0.543931624 serum_fattyacid serum_aminoacids 0.0236 0.316 no dn no no no no UFA%+blood L-Asparagine+blood 0 0.578431373 0.667692308 serum_fattyacid serum_aminoacids 0.0236 0.784 no dn no no no no UFA%+blood L-Glutamic acid+blood 0 0.504901961 0 yes serum_fattyacid serum_aminoacids 0.0236 6.20E-05 no dn no up up no UFA%+blood L-Glutamine+blood 0.455639098 0 0.831111111 serum_fattyacid serum_aminoacids 0.0236 0.639 no dn no no no no UFA%+blood L-Histidine+blood 0.535338346 0 0.548717949 serum_fattyacid serum_aminoacids 0.0236 0.109 no dn no no no no UFA%+blood L-Isoleucine+blood 0 0 0.414017094 yes serum_fattyacid serum_aminoacids 0.0236 5.47E-06 no dn no up up no UFA%+blood L-Leucine+blood 0 0 0.47008547 yes serum_fattyacid serum_aminoacids 0.0236 3.22E-05 no dn no up up no UFA%+blood L-Lysine+blood 0.458646617 0.573529412 0.422905983 yes serum_fattyacid serum_aminoacids 0.0236 0.0107 no dn no no up no UFA%+blood L-Methionine+blood 0 0.551470588 0 serum_fattyacid serum_aminoacids 0.0236 0.626 no dn no no no no UFA%+blood L-Phenylalanine+blood 0 0.549019608 0 yes serum_fattyacid serum_aminoacids 0.0236 0.0103 no dn no up up no UFA%+blood L-Tryptophan+blood 0 0 0.486495726 serum_fattyacid serum_aminoacids 0.0236 0.164 no dn no no no no UFA%+blood lauric acid C12+blood 0.514285714 0 0 serum_fattyacid serum_mcfa 0.0236 0.015 no dn no no dn dn UFA%+blood Legionellosis -0.461403509 0 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Lipid and atherosclerosis 0 0.855882353 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Long-term depression 0 0 -0.424615385 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Long-term potentiation 0 -0.520588235 0 serum_fattyacid kegg 0.0236 NA no dn no no no up UFA%+blood Longevity regulating pathway - multiple species -0.457894737 0 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Lysosome 0 0.564705882 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Melanogenesis 0 0 -0.401538462 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood MicroRNAs in cancer 0 0 -0.428461538 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood mRNA surveillance pathway 0 -0.75 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood mTOR signaling pathway 0 -0.717647059 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood MUFA%+blood 0.854135338 0.882352941 0.767521368 serum_fattyacid serum_fattyacid 0.0236 0.00142 no dn no up no dn UFA%+blood Natural killer cell mediated cytotoxicity 0 0.644117647 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Neuroactive ligand-receptor interaction 0 0.7 0 serum_fattyacid kegg 0.0236 NA no dn no up up up UFA%+blood Neutrophil extracellular trap formation 0 0.664705882 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood NF-kappa B signaling pathway 0 0.544117647 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Nicotinate and nicotinamide metabolism 0 0.635294118 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood NOD-like receptor signaling pathway 0 0.697058824 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Non-alcoholic fatty liver disease 0 0 -0.424615385 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood octanoic acid C8+blood 0 0 0.636923077 serum_fattyacid serum_mcfa 0.0236 2.84E-11 no dn no dn dn dn UFA%+blood Olfactory transduction 0 0.638235294 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Osteoclast differentiation 0 0.652941176 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Oxidative phosphorylation 0 -0.544117647 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Pancreatic cancer 0 0 -0.458461538 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood "Parathyroid hormone synthesis, secretion and action" 0 -0.555882353 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Pathogenic Escherichia coli infection 0 0.555882353 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Peroxisome 0 0.641176471 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Pertussis 0 0.773529412 0 serum_fattyacid kegg 0.0236 NA no dn no no no dn UFA%+blood Phagosome 0 0.594117647 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Phospholipase D signaling pathway 0 0 -0.434615385 serum_fattyacid kegg 0.0236 NA no dn no no up up UFA%+blood Prevotella -0.644118401 0 0 acetate-producing serum_fattyacid Genus 0.0236 0.287 no dn no no no no UFA%+blood Prion disease 0 -0.632352941 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Propionic acid+stool 0 0 -0.509774436 yes serum_fattyacid stool_scfa 0.0236 0.0436 no dn no dn no up UFA%+blood Proteasome 0 0 0.520769231 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Protein processing in endoplasmic reticulum 0 -0.726470588 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Proteoglycans in cancer 0 -0.685294118 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood PUFA/MUFA+blood 0.49924812 0.580882353 0.412649573 serum_fattyacid serum_fattyacid 0.0236 0.00108 no dn no dn no up UFA%+blood PUFA/UFA+blood 0.869172932 0.899509804 0.837264957 serum_fattyacid serum_fattyacid 0.0236 0.000732 no dn no dn no up UFA%+blood PUFA%+blood 0.921804511 0.914215686 0.909059829 serum_fattyacid serum_fattyacid 0.0236 0.0013 no dn no dn no up UFA%+blood Ras signaling pathway 0 -0.608823529 0 yes serum_fattyacid kegg 0.0236 NA no dn no no up up UFA%+blood Retrograde endocannabinoid signaling 0 -0.614705882 0 serum_fattyacid kegg 0.0236 NA no dn no no no up UFA%+blood Rheumatoid arthritis 0 0.641176471 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Ribosome 0 -0.658823529 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Ribosome biogenesis in eukaryotes 0 -0.585294118 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood RIG-I-like receptor signaling pathway 0 0.535294118 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood RNA degradation 0 -0.7 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood RNA transport 0 -0.688235294 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Ruminococcus 0 0 -0.436098819 serum_fattyacid Genus 0.0236 0.0679 no dn no no no dn UFA%+blood Salmonella infection 0 0.505882353 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Serine+blood 0.703759398 0.556372549 0.66974359 serum_fattyacid serum_aminoacids 0.0236 0.942 no dn no no no no UFA%+blood SFA%+blood 0.861654135 0.948529412 0.796239316 serum_fattyacid serum_fattyacid 0.0236 0.0236 no dn no no up no UFA%+blood Signaling pathways regulating pluripotency of stem cells 0 0 -0.443846154 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Spinocerebellar ataxia 0 -0.635294118 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Staphylococcus aureus infection 0 0.623529412 0 serum_fattyacid kegg 0.0236 NA no dn no up no no UFA%+blood Systemic lupus erythematosus 0 0.641176471 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood T-a-MCA+blood 0 0 0.425650077 serum_fattyacid serum_bileacids 0.0236 0.478 no dn no no no no UFA%+blood Taurine+blood 0 0.509803922 0 serum_fattyacid serum_aminoacids 0.0236 0.857 no dn no no no no UFA%+blood TCA+stool -0.580468225 0 0 serum_fattyacid stool_bileacids 0.0236 0.458 no dn no no no no UFA%+blood Th1 and Th2 cell differentiation 0.456140351 0 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Thermogenesis 0 -0.632352941 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Toll-like receptor signaling pathway 0 0.602941176 0 yes serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood total_stool_scfa+stool 0 0 -0.455639098 serum_fattyacid stool_scfa 0.0236 0.0534 no dn no dn no up UFA%+blood Toxoplasmosis 0 0.508823529 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Transcriptional misregulation in cancer 0 0.514705882 -0.486923077 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Tuberculosis 0 0.670588235 0 serum_fattyacid kegg 0.0236 NA no dn no no no dn UFA%+blood Type I diabetes mellitus 0 0.588235294 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Viral carcinogenesis 0 0.614705882 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Viral myocarditis 0 0.508823529 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Wnt signaling pathway 0 -0.755882353 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA%+blood Yersinia infection 0 0.602941176 0 serum_fattyacid kegg 0.0236 NA no dn no no no no UFA+blood 12-ketoDCA+blood -0.513021871 0 0 serum_fattyacid serum_bileacids 0.0444 0.517 up no dn no no no UFA+blood 14:0/16:0-PC+blood 0 0 0.401025641 serum_fattyacid serum_phospholipids 0.0444 0.0358 up no dn no up no UFA+blood 14:0+blood 0.571428571 0 0.553504274 yes serum_fattyacid serum_fattyacid 0.0444 0.00572 up no dn up no dn UFA+blood 16:0/18:1-PC+blood 0 0 0.468717949 serum_fattyacid serum_phospholipids 0.0444 6.15E-07 up no dn up up up UFA+blood 16:0/20:5-PG+blood 0 0 -0.425641026 serum_fattyacid serum_phospholipids 0.0444 0.00656 up no dn no up no UFA+blood 16:0+blood 0.855639098 0.875 0.767521368 yes serum_fattyacid serum_fattyacid 0.0444 0.00876 up no dn up no no UFA+blood 16:1/18:2-PG+blood 0 0 -0.452307692 serum_fattyacid serum_phospholipids 0.0444 1.40E-08 up no dn no up up UFA+blood 16:1+blood 0.801503759 0 0.410598291 yes serum_fattyacid serum_fattyacid 0.0444 0.0186 up no dn no no dn UFA+blood 18:0/16:0-PC+blood 0 0 0.415384615 serum_fattyacid serum_phospholipids 0.0444 9.64E-07 up no dn up up up UFA+blood 18:0/20:4-PI+blood 0 0.575980392 0 serum_fattyacid serum_phospholipids 0.0444 0.167 up no dn no no no UFA+blood 18:0+blood 0.739849624 0.661764706 0.627350427 serum_fattyacid serum_fattyacid 0.0444 0.344 up no dn no no no UFA+blood 18:1/18:0-PS+blood 0 0.642156863 0 serum_fattyacid serum_phospholipids 0.0444 0.193 up no dn no no no UFA+blood 18:1/18:1-PG+blood 0 0 -0.44 serum_fattyacid serum_phospholipids 0.0444 0.00352 up no dn no up up UFA+blood 18:1/18:2-PG+blood 0 0 -0.450940171 serum_fattyacid serum_phospholipids 0.0444 5.58E-07 up no dn no up up UFA+blood 18:1+blood 0.891729323 0.710784314 0.634871795 yes serum_fattyacid serum_fattyacid 0.0444 0.00202 up no dn up no dn UFA+blood 18:2n6c+blood 0.663157895 0.740196078 0.791452991 serum_fattyacid serum_fattyacid 0.0444 0.15 up no dn no no no UFA+blood 18:3n3+blood 0.648120301 0 0 serum_fattyacid serum_fattyacid 0.0444 0.291 up no dn no no no UFA+blood 20:2/18:3-PE+blood 0 0.605392157 0 serum_fattyacid serum_phospholipids 0.0444 0.0391 up no dn up up no UFA+blood 20:3/16:0-PC+blood 0 0.509803922 0 serum_fattyacid serum_phospholipids 0.0444 0.00405 up no dn no up up UFA+blood 20:3/18:0-PC+blood 0.446616541 0 0 serum_fattyacid serum_phospholipids 0.0444 0.296 up no dn no no no UFA+blood 20:3/18:0-PI+blood 0 0.507352941 0 serum_fattyacid serum_phospholipids 0.0444 0.289 up no dn no no no UFA+blood 20:3n6+blood 0 0 0.441367521 serum_fattyacid serum_fattyacid 0.0444 0.0884 up no dn up no no UFA+blood 20:4-LPE+blood 0 0.578431373 0 serum_fattyacid serum_phospholipids 0.0444 0.552 up no dn no no no UFA+blood 20:4/18:0-PE+blood 0 0.50245098 0 serum_fattyacid serum_phospholipids 0.0444 0.000755 up no dn up up no UFA+blood 20:4n6+blood 0 0.588235294 0 serum_fattyacid serum_fattyacid 0.0444 0.133 up no dn no no no UFA+blood 22:6n3+blood 0.458646617 0 0 serum_fattyacid serum_fattyacid 0.0444 0.792 up no dn no no no UFA+blood 24:0+blood 0 0.50245098 0 serum_fattyacid serum_fattyacid 0.0444 0.034 up no dn dn no up UFA+blood 24:1+blood 0 0.62745098 0 serum_fattyacid serum_fattyacid 0.0444 0.00582 up no dn no dn dn UFA+blood 3-(3-Hydroxyphenyl)propanoic acid+stool 0.642857143 0 0 serum_fattyacid stool_cometabolism 0.0444 0.33 up no dn no no no UFA+blood AA+blood 0.508270677 0 0 serum_fattyacid serum_ARA 0.0444 0.212 up no dn no no no UFA+blood AGE-RAGE signaling pathway in diabetic complications 0.614035088 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Alzheimer disease 0 0 -0.428461538 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Bifidobacterium 0 -0.695279101 0 acetate-producing serum_fattyacid Genus 0.0444 0.105 up no dn no dn no UFA+blood Biosynthesis of cofactors -0.559649123 0 0.48 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Cardiac muscle contraction 0 0 -0.46 serum_fattyacid kegg 0.0444 NA up no dn no no up UFA+blood cGMP-PKG signaling pathway 0.466666667 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Cholinergic synapse 0.456140351 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Cytokine-cytokine receptor interaction 0.489473684 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Focal adhesion 0 0 -0.409230769 serum_fattyacid kegg 0.0444 NA up no dn no up up UFA+blood GABAergic synapse 0.515789474 0 0 serum_fattyacid kegg 0.0444 NA up no dn no up up UFA+blood GCDCA+blood 0 0 -0.426324786 serum_fattyacid serum_bileacids 0.0444 0.31 up no dn no no no UFA+blood GLCA+blood 0 -0.560112034 -0.471233443 serum_fattyacid serum_bileacids 0.0444 0.319 up no dn no no no UFA+blood Glioma 0.533333333 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Glutathione metabolism 0 0 0.416923077 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood "Glycine, serine and threonine metabolism" -0.456140351 -0.652941176 0.442307692 serum_fattyacid kegg 0.0444 NA up no dn no up no UFA+blood HCA+blood 0 0 -0.425436597 serum_fattyacid serum_bileacids 0.0444 0.544 up no dn no no no UFA+blood iso-DCA+blood 0 0 0.463247863 serum_fattyacid serum_bileacids 0.0444 0.38 up no dn no no no UFA+blood iso-LCA+blood -0.4804104 0 0 serum_fattyacid serum_bileacids 0.0444 0.507 up no dn no no no UFA+blood isovaleric acid iso-C5+blood 0 0.526960784 0 serum_fattyacid serum_scfa 0.0444 0.117 up no dn no no no UFA+blood L-Leucine+blood -0.467669173 0 0 yes serum_fattyacid serum_aminoacids 0.0444 3.22E-05 up no dn up up no UFA+blood L-Proline+blood -0.509774436 0 -0.464615385 yes serum_fattyacid serum_aminoacids 0.0444 0.00265 up no dn up up no UFA+blood LCA+blood -0.469163334 0 0 serum_fattyacid serum_bileacids 0.0444 0.884 up no dn no no no UFA+blood Lipid and atherosclerosis 0.654385965 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Mitophagy - animal -0.51754386 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood MUFA+blood 0.89924812 0.720588235 0.627350427 serum_fattyacid serum_fattyacid 0.0444 0.00175 up no dn up no dn UFA+blood n6+blood 0.855639098 0.911764706 0.943931624 serum_fattyacid serum_fattyacid 0.0444 0.153 up no dn no no no UFA+blood NOD-like receptor signaling pathway 0.587719298 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Parkinson disease -0.487719298 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Pathways of neurodegeneration - multiple diseases -0.496491228 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Peroxisome 0.485964912 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Pertussis 0.650877193 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no dn UFA+blood Porphyrin and chlorophyll metabolism -0.5 -0.658823529 0.482307692 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Proteoglycans in cancer -0.515789474 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood PUFA/MUFA+blood -0.478195489 0 0 serum_fattyacid serum_fattyacid 0.0444 0.00108 up no dn dn no up UFA+blood PUFA+blood 0.933834586 0.950980392 0.932307692 serum_fattyacid serum_fattyacid 0.0444 0.212 up no dn no no no UFA+blood Purine metabolism 0 -0.517647059 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Ruminococcus 0 -0.526960784 0 acetate-producing serum_fattyacid Genus 0.0444 0.335 up no dn no no no UFA+blood Salivary secretion 0 0.511764706 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood SFA+blood 0.855639098 0.899509804 0.834529915 serum_fattyacid serum_fattyacid 0.0444 0.0386 up no dn up no no UFA+blood Shigellosis -0.622807018 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood Sphingolipid signaling pathway 0.456140351 0 -0.499230769 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood T-a-MCA+blood 0 0 0.516816809 serum_fattyacid serum_bileacids 0.0444 0.478 up no dn no no no UFA+blood ToFA+blood 0.966917293 0.985294118 0.952820513 serum_fattyacid serum_fattyacid 0.0444 0.0307 up no dn up no dn UFA+blood Tuberculosis 0.505263158 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no dn UFA+blood Ubiquitin mediated proteolysis -0.556140351 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no UFA+blood VEGF signaling pathway 0.489473684 0 0 serum_fattyacid kegg 0.0444 NA up no dn no no no undecanoid acid C11+blood 12-HEPE+blood 0.505555573 0 0 serum_mcfa serum_ARA 1.35E-10 0.312 dn dn no no no no undecanoid acid C11+blood 14:0/18:0-PC+blood 0 0.512254902 0 serum_mcfa serum_phospholipids 1.35E-10 0.00289 dn dn no up up no undecanoid acid C11+blood 14:0/18:2-PC+blood 0 0.558823529 0 serum_mcfa serum_phospholipids 1.35E-10 0.102 dn dn no no up no undecanoid acid C11+blood 14:1/18:2-PG+blood 0 0.495098039 0 serum_mcfa serum_phospholipids 1.35E-10 0.00259 dn dn no no up up undecanoid acid C11+blood 16:0/16:0-PC+blood 0 0 -0.461196581 serum_mcfa serum_phospholipids 1.35E-10 0.00079 dn dn no no up up undecanoid acid C11+blood 16:0/16:1-PC+blood 0 0.482843137 0 serum_mcfa serum_phospholipids 1.35E-10 0.00283 dn dn no up up no undecanoid acid C11+blood 16:0/16:1-PI+blood -0.497744361 0 0 serum_mcfa serum_phospholipids 1.35E-10 0.262 dn dn no no no no undecanoid acid C11+blood 16:0/18:3-PC+blood -0.497744361 0 0 serum_mcfa serum_phospholipids 1.35E-10 0.00216 dn dn no no up up undecanoid acid C11+blood 16:0/22:0-PE+blood 0 -0.514705882 0 serum_mcfa serum_phospholipids 1.35E-10 0.00839 dn dn no dn no up undecanoid acid C11+blood 18:0-LPC+blood 0 0.539215686 0 serum_mcfa serum_phospholipids 1.35E-10 0.554 dn dn no no no no undecanoid acid C11+blood 18:0-LPE+blood 0 0.634803922 0 serum_mcfa serum_phospholipids 1.35E-10 0.491 dn dn no no no no undecanoid acid C11+blood 18:0/18:2-PC+blood 0.455639098 0 0 serum_mcfa serum_phospholipids 1.35E-10 1.74E-06 dn dn no no up up undecanoid acid C11+blood 18:0/18:2-PI+blood 0 0.504901961 0 serum_mcfa serum_phospholipids 1.35E-10 0.179 dn dn no no no no undecanoid acid C11+blood 18:0/20:4-PC+blood 0 0 -0.404444444 serum_mcfa serum_phospholipids 1.35E-10 0.454 dn dn no no no no undecanoid acid C11+blood 18:0+blood 0 0 -0.40991453 serum_mcfa serum_fattyacid 1.35E-10 0.344 dn dn no no no no undecanoid acid C11+blood 18:1-LPC+blood 0.506766917 0 0 serum_mcfa serum_phospholipids 1.35E-10 0.179 dn dn no no no no undecanoid acid C11+blood 18:1/18:0-PC+blood 0.44962406 0 0 serum_mcfa serum_phospholipids 1.35E-10 1.83E-06 dn dn no no up up undecanoid acid C11+blood 18:1/18:1-PC+blood 0 0.482843137 0 serum_mcfa serum_phospholipids 1.35E-10 1.34E-05 dn dn no no up up undecanoid acid C11+blood 18:1/18:1-PI+blood 0.557894737 0 0 serum_mcfa serum_phospholipids 1.35E-10 0.111 dn dn no dn no no undecanoid acid C11+blood 18:1/20:3-PC+blood 0 0 -0.403760684 serum_mcfa serum_phospholipids 1.35E-10 0.00872 dn dn no no up up undecanoid acid C11+blood 18:1/20:4-PI+blood 0 0 -0.528888889 serum_mcfa serum_phospholipids 1.35E-10 0.192 dn dn no no no no undecanoid acid C11+blood 18:2-LPC+blood 0.568421053 0 0 serum_mcfa serum_phospholipids 1.35E-10 0.00743 dn dn no dn no up undecanoid acid C11+blood 18:2-LPE+blood 0 0.620098039 0 serum_mcfa serum_phospholipids 1.35E-10 0.112 dn dn no no no no undecanoid acid C11+blood 18:2/16:0-PC+blood 0.454135338 0 0 serum_mcfa serum_phospholipids 1.35E-10 8.67E-05 dn dn no no up up undecanoid acid C11+blood 18:2/18:1-PC+blood 0.476691729 0 0 serum_mcfa serum_phospholipids 1.35E-10 2.30E-05 dn dn no dn up up undecanoid acid C11+blood 18:3/16:0-PE+blood -0.679699248 0 0 serum_mcfa serum_phospholipids 1.35E-10 0.00149 dn dn no up up no undecanoid acid C11+blood 18:3n6+blood 0 0 -0.52957265 serum_mcfa serum_fattyacid 1.35E-10 0.0463 dn dn no up no dn undecanoid acid C11+blood 2-methyl-butyric acid m-C4+blood 0.616541353 0 0 serum_mcfa serum_scfa 1.35E-10 0.262 dn dn no no no no undecanoid acid C11+blood 20:2-LPC+blood 0 0 -0.408547009 serum_mcfa serum_phospholipids 1.35E-10 0.119 dn dn no no no up undecanoid acid C11+blood 20:2+blood 0 0.512254902 0 serum_mcfa serum_fattyacid 1.35E-10 0.478 dn dn no no no no undecanoid acid C11+blood 20:3-LPE+blood 0 0.639705882 0 serum_mcfa serum_phospholipids 1.35E-10 0.084 dn dn no no up no undecanoid acid C11+blood 20:3n6+blood 0 0.56127451 0 serum_mcfa serum_fattyacid 1.35E-10 0.0884 dn dn no up no no undecanoid acid C11+blood 20:5-LPC+blood 0 -0.671568627 0 serum_mcfa serum_phospholipids 1.35E-10 0.558 dn dn no no no no undecanoid acid C11+blood 22:2-LPA+blood 0 0.492647059 0 serum_mcfa serum_phospholipids 1.35E-10 0.0443 dn dn no dn no no undecanoid acid C11+blood 22:6-LPC+blood 0 -0.50245098 0 serum_mcfa serum_phospholipids 1.35E-10 0.127 dn dn no no no up undecanoid acid C11+blood 24:1+blood 0 -0.524509804 0 serum_mcfa serum_fattyacid 1.35E-10 0.00582 dn dn no no dn dn undecanoid acid C11+blood Creatinine+blood 0.538345865 0 0 serum_mcfa serum_choline 1.35E-10 0.437 dn dn no no no no undecanoid acid C11+blood Cysteine+blood 0.506766917 0 0 yes serum_mcfa serum_aminoacids 1.35E-10 1.81E-07 dn dn no dn up up undecanoid acid C11+blood decanoic acid C10+blood 0.942857143 0.754901961 0.551452991 serum_mcfa serum_mcfa 1.35E-10 6.64E-11 dn dn no dn dn no undecanoid acid C11+blood DHA+blood 0 0 0.418119658 serum_mcfa serum_ARA 1.35E-10 0.872 dn dn no no no no undecanoid acid C11+blood EPA+blood 0 -0.495098039 0 serum_mcfa serum_ARA 1.35E-10 0.212 dn dn no no no no undecanoid acid C11+blood HDCA+blood 0 0 0.437711631 serum_mcfa serum_bileacids 1.35E-10 0.483 dn dn no no no no undecanoid acid C11+blood heptanoic acid C7+blood 0.630075188 0.632352941 0 serum_mcfa serum_mcfa 1.35E-10 8.27E-11 dn dn no dn dn no undecanoid acid C11+blood isobutyric acid C4+blood 0.518796992 0 0 serum_mcfa serum_scfa 1.35E-10 0.0151 dn dn no up up no undecanoid acid C11+blood L-Alanine+blood 0 0 -0.424273504 yes serum_mcfa serum_aminoacids 1.35E-10 0.00138 dn dn no up up no undecanoid acid C11+blood L-Methionine+blood 0.452631579 0 0 serum_mcfa serum_aminoacids 1.35E-10 0.626 dn dn no no no no undecanoid acid C11+blood lauric acid C12+blood 0.896240602 0.723039216 0.680683761 serum_mcfa serum_mcfa 1.35E-10 0.015 dn dn no no dn dn undecanoid acid C11+blood LCA+blood 0 0.499012052 0 serum_mcfa serum_bileacids 1.35E-10 0.884 dn dn no no no no undecanoid acid C11+blood nonanoic acid C9+blood 0.771428571 0.789215686 0.79008547 serum_mcfa serum_mcfa 1.35E-10 6.51E-11 dn dn no dn dn no undecanoid acid C11+blood octanoic acid C8+blood 0.672180451 0.529411765 0 serum_mcfa serum_mcfa 1.35E-10 2.84E-11 dn dn no dn dn dn undecanoid acid C11+blood TMAO+blood 0.503759398 0 0 serum_mcfa serum_choline 1.35E-10 0.00706 dn dn no up up no undecanoid acid C11+blood total_blood_mcfa+blood 0.923308271 0.740196078 0.742222222 serum_mcfa serum_mcfa 1.35E-10 8.76E-11 dn dn no dn dn dn valeric acid C5+blood 12-HEPE+blood 0 0.484097716 0 serum_scfa serum_ARA 0.00202 0.312 dn dn no no no no valeric acid C5+blood 12-ketoDCA+blood 0 0.517029533 0 serum_scfa serum_bileacids 0.00202 0.517 dn dn no no no no valeric acid C5+blood 16:1/16:1-PC+blood 0 -0.625 0 serum_scfa serum_phospholipids 0.00202 0.0177 dn dn no no no up valeric acid C5+blood 18:0+blood 0.466165414 0 0 serum_scfa serum_fattyacid 0.00202 0.344 dn dn no no no no valeric acid C5+blood 18:1-LPC+blood 0 0.524509804 0 serum_scfa serum_phospholipids 0.00202 0.179 dn dn no no no no valeric acid C5+blood 18:1/18:2-PI+blood -0.544360902 0 0 serum_scfa serum_phospholipids 0.00202 0.0164 dn dn no dn no up valeric acid C5+blood 2-methyl-butyric acid m-C4+blood 0.646616541 0.794117647 0.777094017 serum_scfa serum_scfa 0.00202 0.262 dn dn no no no no valeric acid C5+blood 20:0-LPC+blood 0 0.529411765 -0.416752137 serum_scfa serum_phospholipids 0.00202 0.199 dn dn no no no no valeric acid C5+blood 22:0/16:0-PE+blood 0 0 -0.403760684 serum_scfa serum_phospholipids 0.00202 0.091 dn dn no no no up valeric acid C5+blood 22:2-LPA+blood -0.445112782 0 0 serum_scfa serum_phospholipids 0.00202 0.0443 dn dn no dn no no valeric acid C5+blood 9-HODE+blood -0.554887218 0 0 serum_scfa serum_ARA 0.00202 0.297 dn dn no no no no valeric acid C5+blood acetic acid C2+blood 0.557894737 0 0 serum_scfa serum_scfa 0.00202 0.000193 dn dn no up dn no valeric acid C5+blood butyric acid C4+blood 0.759398496 0.56372549 0.726495726 serum_scfa serum_scfa 0.00202 0.407 dn dn no no no no valeric acid C5+blood Cystine+blood 0.566917293 0 0 yes serum_scfa serum_aminoacids 0.00202 0.00028 dn dn no up up no valeric acid C5+blood decanoic acid C10+blood 0.553383459 0 0 serum_scfa serum_mcfa 0.00202 6.64E-11 dn dn no dn dn no valeric acid C5+blood heptanoic acid C7+blood 0.792481203 0 0.502222222 serum_scfa serum_mcfa 0.00202 8.27E-11 dn dn no dn dn no valeric acid C5+blood iso-heptanoic acid C7+blood 0.467669173 0 0 serum_scfa serum_mcfa 0.00202 0.00256 dn dn no up up no valeric acid C5+blood iso-LCA+blood 0 0.780064817 0 serum_scfa serum_bileacids 0.00202 0.507 dn dn no no no no valeric acid C5+blood isobutyric acid C4+blood 0.763909774 0.661764706 0.859145299 serum_scfa serum_scfa 0.00202 0.0151 dn dn no up up no valeric acid C5+blood L-Asparagine+blood 0.523308271 0 0 serum_scfa serum_aminoacids 0.00202 0.784 dn dn no no no no valeric acid C5+blood L-Lysine+blood 0.45112782 0 0 yes serum_scfa serum_aminoacids 0.00202 0.0107 dn dn no no up no valeric acid C5+blood lauric acid C12+blood 0.45112782 0 0 serum_scfa serum_mcfa 0.00202 0.015 dn dn no no dn dn valeric acid C5+blood LCA+blood 0 0.487540511 0 serum_scfa serum_bileacids 0.00202 0.884 dn dn no no no no valeric acid C5+blood nonanoic acid C9+blood 0.720300752 0 0 serum_scfa serum_mcfa 0.00202 6.51E-11 dn dn no dn dn no valeric acid C5+blood octanoic acid C8+blood 0.759398496 0 0 serum_scfa serum_mcfa 0.00202 2.84E-11 dn dn no dn dn dn valeric acid C5+blood propionic acid C3+blood 0.905263158 0.654411765 0.856410256 serum_scfa serum_scfa 0.00202 0.104 dn dn no no dn no valeric acid C5+blood Serine+blood 0.446616541 0 0 serum_scfa serum_aminoacids 0.00202 0.942 dn dn no no no no valeric acid C5+blood total_blood_mcfa+blood 0.712781955 0 0 serum_scfa serum_mcfa 0.00202 8.76E-11 dn dn no dn dn dn valeric acid C5+blood undecanoid acid C11+blood 0.527819549 0 0 serum_scfa serum_mcfa 0.00202 1.35E-10 dn dn no dn dn no Valeric acid+stool CA+stool -0.82868937 -0.853146853 0 stool_scfa stool_bileacids 0.382 0.827 no no no no no no Valeric acid+stool Caproic acid+stool 0 0.58041958 0.612648221 stool_scfa stool_scfa 0.382 0.882 no no no no no no Valeric acid+stool CDCA+stool -0.746130031 -0.902097902 -0.421936759 stool_scfa stool_bileacids 0.382 0.663 no no no no no no Valeric acid+stool DCA+stool 0 0 0.609683794 stool_scfa stool_bileacids 0.382 0.195 no no no no no no Valeric acid+stool GCA+stool -0.517027864 -0.944055944 -0.468379447 stool_scfa stool_bileacids 0.382 0.0809 no no no no no no Valeric acid+stool GCDCA+stool 0 -0.727272727 -0.477272727 yes stool_scfa stool_bileacids 0.382 0.0471 no no no no dn no Valeric acid+stool GDCA+stool -0.481156492 -0.826621233 -0.552918174 stool_scfa stool_bileacids 0.382 0.656 no no no no no no Valeric acid+stool GLCA+stool -0.521370374 0 0 stool_scfa stool_bileacids 0.382 0.617 no no no no no no Valeric acid+stool HCA+stool -0.675954592 0 0 stool_scfa stool_bileacids 0.382 0.155 no no no no no no Valeric acid+stool HDCA+stool 0.593395253 0 0.467391304 stool_scfa stool_bileacids 0.382 0.176 no no no no no no Valeric acid+stool Indole-3-Acetic acid+stool 0 0.727272727 0 stool_scfa stool_cometabolism 0.382 0.304 no no no no no no Valeric acid+stool iso-LCA+stool 0.654620634 0.72027972 0 stool_scfa stool_bileacids 0.382 0.72 no no no no no no Valeric acid+stool Isobutyric acid+stool 0.494324045 0.79020979 0.454545455 stool_scfa stool_scfa 0.382 0.408 no no no no no no Valeric acid+stool Isovaleric acid+stool 0 0.657342657 0.424901186 stool_scfa stool_scfa 0.382 0.343 no no no no no no Valeric acid+stool LCA+stool 0 0.734265734 0.469367589 stool_scfa stool_bileacids 0.382 0.314 no no no no no no Valeric acid+stool nutriCA+stool -0.731682147 0 -0.435770751 stool_scfa stool_bileacids 0.382 0.481 no no no no no no Valeric acid+stool TCA+stool 0 0 -0.559288538 stool_scfa stool_bileacids 0.382 0.458 no no no no no no Valeric acid+stool TDCA+stool 0 0 -0.468993666 stool_scfa stool_bileacids 0.382 0.963 no no no no no no Valeric acid+stool UDCA+stool -0.704850361 -0.902097902 0 stool_scfa stool_bileacids 0.382 0.266 no no no no no no Valeric acid+stool ¦Ø-MCA+stool 0 0 -0.565698782 stool_scfa stool_bileacids 0.382 0.919 no no no no no no "Valine, leucine and isoleucine degradation" "Alanine, aspartate and glutamate metabolism" 0 -0.597826087 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Arginine biosynthesis 0 -0.640316206 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Ascorbate and aldarate metabolism 0.607826087 0.664031621 0.673873874 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Citrate cycle (TCA cycle) 0.909565217 0.924901186 0.785842986 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Cysteine and methionine metabolism 0.688695652 0.783596838 0.695238095 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Fatty acid biosynthesis 0 -0.566205534 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Fatty acid degradation 0.446086957 0 0.56962677 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Fatty acid elongation 0.68 0.615612648 0.811583012 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Fructose and mannose metabolism 0.566956522 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Galactose metabolism 0.575652174 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Glycolysis / Gluconeogenesis 0.712173913 0.588932806 0.536164736 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Oxidative phosphorylation -0.431304348 0 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Pentose and glucuronate interconversions 0.715652174 0.904150198 0.616216216 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Pentose phosphate pathway 0 -0.45256917 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Primary bile acid biosynthesis 0.907826087 0.654150198 0.586872587 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Pyrimidine metabolism 0.706086957 0.716403162 0 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Steroid biosynthesis 0 0.761857708 0.714285714 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Steroid hormone biosynthesis 0.653043478 0.839920949 0.413127413 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Synthesis and degradation of ketone bodies 0.839130435 0.82312253 0.819047619 kegg kegg NA NA no no no no no no "Valine, leucine and isoleucine degradation" Ubiquinone and other terpenoid-quinone biosynthesis 0.916521739 0.937747036 0.677477477 kegg kegg NA NA no no no no no no Valine+blood 15-HETE+blood 0 0 -0.542548037 yes serum_aminoacids serum_ARA 1.22E-06 0.819 up up no no no no Valine+blood 16:0/14:0-PC+blood 0.526315789 0 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.0206 up up no no up up Valine+blood 16:0/18:2-PC+blood 0.526315789 0 0 yes serum_aminoacids serum_phospholipids 1.22E-06 3.24E-06 up up no no up up Valine+blood 16:0/20:4-PE+blood 0 0 -0.417435897 yes serum_aminoacids serum_phospholipids 1.22E-06 0.00139 up up no up up no Valine+blood 16:0/22:6-PC+blood 0.466165414 0 0 yes serum_aminoacids serum_phospholipids 1.22E-06 4.53E-05 up up no no up up Valine+blood 16:0/22:6-PE+blood 0 -0.509803922 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.000934 up up no up up no Valine+blood 16:1/16:0-PC+blood 0.606015038 0 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.0215 up up no no up up Valine+blood 18:0-LPE+blood 0 0 -0.473504274 yes serum_aminoacids serum_phospholipids 1.22E-06 0.491 up up no no no no Valine+blood 18:1-LPE+blood -0.506766917 0 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.117 up up no no no no Valine+blood 18:1/16:0-PC+blood 0.529323308 0 0 yes serum_aminoacids serum_phospholipids 1.22E-06 2.43E-05 up up no no up up Valine+blood 18:1/20:4-PE+blood 0 0 -0.423589744 yes serum_aminoacids serum_phospholipids 1.22E-06 0.0578 up up no up no no Valine+blood 18:3n6+blood -0.530827068 0 0 yes serum_aminoacids serum_fattyacid 1.22E-06 0.0463 up up no up no dn Valine+blood 20:0+blood 0 -0.495098039 0 yes yes serum_aminoacids serum_fattyacid 1.22E-06 0.000278 up up no dn no up Valine+blood 20:1-LPA+blood 0 0.514705882 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.0187 up up no dn dn no Valine+blood 20:1-LPE+blood 0 -0.512254902 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.465 up up no no no no Valine+blood 20:2-LPE+blood 0 -0.617647059 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.177 up up no no no no Valine+blood 20:4-LPE+blood 0 0 -0.414017094 yes serum_aminoacids serum_phospholipids 1.22E-06 0.552 up up no no no no Valine+blood 20:4/16:0-PE+blood -0.448120301 0 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.00529 up up no no up up Valine+blood 20:4/18:0-PE+blood 0 0 -0.421538462 yes serum_aminoacids serum_phospholipids 1.22E-06 0.000755 up up no up up no Valine+blood 20:5/18:0-PC+blood 0.461654135 0 0 yes serum_aminoacids serum_phospholipids 1.22E-06 3.97E-06 up up no no up up Valine+blood 22:1-LPA+blood 0 0.487745098 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.00373 up up no no up up Valine+blood 22:6-LPC+blood 0 0 0.417435897 yes serum_aminoacids serum_phospholipids 1.22E-06 0.127 up up no no no up Valine+blood 9-HODE+blood 0 0 -0.401025641 yes serum_aminoacids serum_ARA 1.22E-06 0.297 up up no no no no Valine+blood Axon guidance 0 0 -0.487692308 yes serum_aminoacids kegg 1.22E-06 NA up up no no up up Valine+blood Betaine+blood 0 0 0.431111111 yes serum_aminoacids serum_choline 1.22E-06 0.857 up up no no no no Valine+blood Blautia 0 0.629901961 0 yes acetate-producing serum_aminoacids Genus 1.22E-06 1.36E-05 up up no up dn dn Valine+blood Butyricimonas 0 -0.500315948 0 yes butyrate-producing serum_aminoacids Genus 1.22E-06 0.17 up up no no no no Valine+blood Cell adhesion molecules 0 0 -0.488461538 yes serum_aminoacids kegg 1.22E-06 NA up up no no no no Valine+blood Cellular senescence 0 0 -0.412307692 yes serum_aminoacids kegg 1.22E-06 NA up up no no no no Valine+blood Chemical carcinogenesis - receptor activation 0 -0.529411765 0 yes serum_aminoacids kegg 1.22E-06 NA up up no no no no Valine+blood Choline+blood 0.530827068 0 0.447521368 yes serum_aminoacids serum_choline 1.22E-06 0.0395 up up no no up no Valine+blood Cholinergic synapse 0 -0.658823529 0 yes serum_aminoacids kegg 1.22E-06 NA up up no no no no Valine+blood Creatinine+blood 0.69924812 0.676470588 0 yes serum_aminoacids serum_choline 1.22E-06 0.437 up up no no no no Valine+blood Cysteine+blood 0 0 0.48991453 yes yes serum_aminoacids serum_aminoacids 1.22E-06 1.81E-07 up up no dn up up Valine+blood Cystine+blood 0 0.531862745 0 yes yes serum_aminoacids serum_aminoacids 1.22E-06 0.00028 up up no up up no Valine+blood d18:0-16:0-SM+blood -0.57593985 0 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.202 up up no no no no Valine+blood d18:0-24:1-SM+blood -0.517293233 0 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.0609 up up no no dn dn Valine+blood d18:1-16:0-SM+blood -0.556390977 0 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.14 up up no no no no Valine+blood d18:1-16:1-SM+blood -0.613533835 0 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.2 up up no no no no Valine+blood d18:1-20:0-SM+blood -0.461654135 0 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.933 up up no no no no Valine+blood d18:1-22:1-SM+blood -0.601503759 0 0 yes serum_aminoacids serum_phospholipids 1.22E-06 0.222 up up no no no no Valine+blood DL-methionine sulfoxide+blood 0 0.556372549 0 yes serum_aminoacids serum_aminoacids 1.22E-06 0.302 up up no no no no Valine+blood DMG+blood 0 0 0.527521368 yes serum_aminoacids serum_choline 1.22E-06 0.909 up up no no no no Valine+blood ErbB signaling pathway 0 -0.611764706 0 yes serum_aminoacids kegg 1.22E-06 NA up up no no no no Valine+blood Ethanolamine+blood 0 0 0.52 yes serum_aminoacids serum_aminoacids 1.22E-06 0.122 up up no up no no Valine+blood Gastric cancer 0 -0.502941176 0 yes serum_aminoacids kegg 1.22E-06 NA up up no no no no Valine+blood GCDCA+stool 0 0.654545455 0 yes yes serum_aminoacids stool_bileacids 1.22E-06 0.0471 up up no no dn no Valine+blood GDCA+stool -0.626373626 0.820047686 0 yes serum_aminoacids stool_bileacids 1.22E-06 0.656 up up no no no no Valine+blood heptanoic acid C7+blood 0 0 0.534358974 yes serum_aminoacids serum_mcfa 1.22E-06 8.27E-11 up up no dn dn no Valine+blood iso-DCA+blood 0 0 0.516581197 yes serum_aminoacids serum_bileacids 1.22E-06 0.38 up up no no no no Valine+blood isobutyric acid C4+blood 0.535338346 0 0 yes serum_aminoacids serum_scfa 1.22E-06 0.0151 up up no up up no Valine+blood L-Alanine+blood 0 0.558823529 0 yes yes serum_aminoacids serum_aminoacids 1.22E-06 0.00138 up up no up up no Valine+blood L-Arginine+blood 0.664661654 0 0.404444444 yes serum_aminoacids serum_aminoacids 1.22E-06 0.316 up up no no no no Valine+blood L-Asparagine+blood 0.44962406 0.50245098 0 yes serum_aminoacids serum_aminoacids 1.22E-06 0.784 up up no no no no Valine+blood L-Citrulline+blood 0 0 0.535042735 yes serum_aminoacids serum_aminoacids 1.22E-06 0.534 up up no no no no Valine+blood L-Glutamic acid+blood 0 0.649509804 0.439316239 yes yes serum_aminoacids serum_aminoacids 1.22E-06 6.20E-05 up up no up up no Valine+blood L-Glutamine+blood 0.57593985 0.482843137 0 yes serum_aminoacids serum_aminoacids 1.22E-06 0.639 up up no no no no Valine+blood L-Histidine+blood 0.663157895 0 0.634871795 yes serum_aminoacids serum_aminoacids 1.22E-06 0.109 up up no no no no Valine+blood L-Isoleucine+blood 0.891729323 0.924019608 0.900854701 yes yes serum_aminoacids serum_aminoacids 1.22E-06 5.47E-06 up up no up up no Valine+blood L-Leucine+blood 0.705263158 0.759803922 0.842735043 yes yes serum_aminoacids serum_aminoacids 1.22E-06 3.22E-05 up up no up up no Valine+blood L-Lysine+blood 0.718796992 0.740196078 0.604786325 yes yes serum_aminoacids serum_aminoacids 1.22E-06 0.0107 up up no no up no Valine+blood L-Methionine+blood 0 0.860294118 0.431111111 yes serum_aminoacids serum_aminoacids 1.22E-06 0.626 up up no no no no Valine+blood L-Ornithine+blood 0 0 0.482393162 yes serum_aminoacids serum_aminoacids 1.22E-06 0.175 up up no no no no Valine+blood L-Phenylalanine+blood 0.560902256 0.715686275 0.808547009 yes yes serum_aminoacids serum_aminoacids 1.22E-06 0.0103 up up no up up no Valine+blood L-Threonine+blood 0 0.50245098 0 yes serum_aminoacids serum_aminoacids 1.22E-06 0.0538 up up no dn no up Valine+blood L-Tryptophan+blood 0.577443609 0.759803922 0.583589744 yes serum_aminoacids serum_aminoacids 1.22E-06 0.164 up up no no no no Valine+blood L-Tyrosine+blood 0 0.710784314 0.676581197 yes yes serum_aminoacids serum_aminoacids 1.22E-06 0.00913 up up no up up no Valine+blood Methanobrevibacter 0 0 0.514902851 yes serum_aminoacids Genus 1.22E-06 0.629 up up no no no no Valine+blood MUFA%+blood 0 0.556372549 0 yes serum_aminoacids serum_fattyacid 1.22E-06 0.00142 up up no up no dn Valine+blood Non-small cell lung cancer 0 -0.526470588 0 yes serum_aminoacids kegg 1.22E-06 NA up up no no no no Valine+blood octanoic acid C8+blood 0 0 0.442051282 yes serum_aminoacids serum_mcfa 1.22E-06 2.84E-11 up up no dn dn dn Valine+blood Oscillospira 0 0 0.420854701 yes LPS-producing serum_aminoacids Genus 1.22E-06 0.62 up up no no no no Valine+blood Parabacteroides 0 0 0.473927174 yes serum_aminoacids Genus 1.22E-06 4.19E-05 up up no no up up Valine+blood Phenylacetic acid+stool 0 -0.681818182 0 yes serum_aminoacids stool_cometabolism 1.22E-06 0.785 up up no no no no Valine+blood PUFA/UFA+blood 0.45112782 0 0 yes serum_aminoacids serum_fattyacid 1.22E-06 0.000732 up up no dn no up Valine+blood PUFA%+blood 0.457142857 0 0 yes serum_aminoacids serum_fattyacid 1.22E-06 0.0013 up up no dn no up Valine+blood Roseburia 0 0 -0.407863248 yes butyrate-producing serum_aminoacids Genus 1.22E-06 0.495 up up no no no no Valine+blood Sarcosine+blood 0 0.647058824 0 yes serum_aminoacids serum_choline 1.22E-06 5.06E-05 up up no up up no Valine+blood Serine+blood 0.533834586 0 0 yes serum_aminoacids serum_aminoacids 1.22E-06 0.942 up up no no no no Valine+blood SFA%+blood 0.491729323 0 0.444786325 yes serum_aminoacids serum_fattyacid 1.22E-06 0.0236 up up no no up no Valine+blood Taurine+blood 0 0 0.552136752 yes serum_aminoacids serum_aminoacids 1.22E-06 0.857 up up no no no no Valine+blood TCA+stool -0.607978567 0 0 yes serum_aminoacids stool_bileacids 1.22E-06 0.458 up up no no no no Valine+blood TXB2+blood 0 0 0.405822513 yes yes serum_aminoacids serum_ARA 1.22E-06 0.0644 up up no dn no no Valine+blood Viral myocarditis 0 0 -0.408461538 yes serum_aminoacids kegg 1.22E-06 NA up up no no no no Various types of N-glycan biosynthesis "Alanine, aspartate and glutamate metabolism" 0 -0.71541502 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Arginine and proline metabolism -0.416521739 -0.663043478 -0.40952381 kegg kegg NA NA no no no no up no Various types of N-glycan biosynthesis Arginine biosynthesis 0 -0.741106719 -0.50990991 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Ascorbate and aldarate metabolism 0 0.421936759 0.424453024 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Citrate cycle (TCA cycle) 0 0.677865613 0.644272844 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Cysteine and methionine metabolism 0.416521739 0.59486166 0.531788932 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Fatty acid biosynthesis 0 -0.704545455 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Glutathione metabolism 0 0 -0.552123552 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis "Glycine, serine and threonine metabolism" 0 0 -0.515315315 kegg kegg NA NA no no no no up no Various types of N-glycan biosynthesis Lysine degradation 0.466956522 0.555335968 0.605405405 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis N-Glycan biosynthesis 0.873043478 0.93083004 0.945431145 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Other glycan degradation 0 0 0.457657658 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Pentose and glucuronate interconversions 0 0.780632411 0.574002574 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Pentose phosphate pathway -0.444347826 -0.593873518 -0.52972973 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Phenylalanine metabolism 0 0.551383399 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Pyrimidine metabolism 0 0.597826087 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Selenocompound metabolism 0.529565217 0 0.64993565 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Starch and sucrose metabolism 0 -0.649209486 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Steroid biosynthesis 0.580869565 0.444664032 0.441441441 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Synthesis and degradation of ketone bodies 0 0.640316206 0.556241956 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Tryptophan metabolism 0 0.473320158 0 kegg kegg NA NA no no no no up no Various types of N-glycan biosynthesis Tyrosine metabolism 0 0.464426877 0 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis Ubiquinone and other terpenoid-quinone biosynthesis 0 0.617588933 0.516602317 kegg kegg NA NA no no no no no no Various types of N-glycan biosynthesis "Valine, leucine and isoleucine degradation" 0 0.685770751 0.503217503 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction 2-Oxocarboxylic acid metabolism -0.428695652 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction ABC transporters -0.675652174 -0.498023715 -0.416473616 kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Adrenergic signaling in cardiomyocytes 0.817391304 0.772727273 0.618275418 kegg kegg NA NA no no no no no up Vascular smooth muscle contraction "Alanine, aspartate and glutamate metabolism" -0.566956522 -0.693675889 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction alpha-Linolenic acid metabolism -0.665217391 -0.616600791 -0.491119691 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Amino sugar and nucleotide sugar metabolism -0.524347826 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Aminoacyl-tRNA biosynthesis -0.648695652 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Apoptosis -0.493913043 -0.514822134 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Apoptosis - multiple species 0 -0.498023715 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Arachidonic acid metabolism 0 0 0.444530245 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Arginine and proline metabolism -0.496521739 -0.651185771 0 kegg kegg NA NA no no no no up no Vascular smooth muscle contraction Arginine biosynthesis -0.564347826 -0.605731225 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Ascorbate and aldarate metabolism 0 0 -0.463835264 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Autophagy - animal 0 -0.756916996 -0.428828829 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Autophagy - other 0 -0.527667984 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction beta-Alanine metabolism -0.611304348 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Biosynthesis of amino acids -0.593043478 -0.48715415 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Biosynthesis of cofactors 0 0 0.469498069 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Biosynthesis of unsaturated fatty acids -0.493913043 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Butanoate metabolism -0.419130435 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Calcium signaling pathway 0.729565217 0.68083004 0.406435006 kegg kegg NA NA no no no no up up Vascular smooth muscle contraction cAMP signaling pathway 0.668695652 0 0.412612613 yes kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Carbon metabolism -0.493043478 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Cardiac muscle contraction 0.66173913 0.828063241 0 kegg kegg NA NA no no no no no up Vascular smooth muscle contraction cGMP-PKG signaling pathway 0 -0.441699605 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Coprococcus 0 0 -0.55820838 butyrate-producing kegg Genus NA 0.612 no no no no no no Vascular smooth muscle contraction Drug metabolism - cytochrome P450 0 0.45256917 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Drug metabolism - other enzymes 0 0.520750988 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction EGFR tyrosine kinase inhibitor resistance 0 0.476284585 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Endocrine resistance 0.463478261 0 0.43011583 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction ErbB signaling pathway 0 -0.586956522 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Ether lipid metabolism 0.633043478 0.450592885 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Fatty acid biosynthesis -0.540869565 -0.708498024 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Fatty acid degradation -0.753043478 -0.748023715 -0.467696268 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Fatty acid metabolism -0.802608696 -0.647233202 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Ferroptosis 0.46 0 0.464092664 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction FoxO signaling pathway 0 -0.742094862 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Fructose and mannose metabolism -0.632173913 -0.586956522 -0.442728443 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Galactose metabolism -0.754782609 -0.725296443 -0.578893179 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Glutathione metabolism 0 0.623517787 0.480823681 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Glycerolipid metabolism -0.570434783 -0.626482213 -0.516602317 kegg kegg NA NA no no no no no up Vascular smooth muscle contraction "Glycine, serine and threonine metabolism" 0 0 0.468211068 kegg kegg NA NA no no no no up no Vascular smooth muscle contraction Glycolysis / Gluconeogenesis -0.48 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.709486166 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Glycosaminoglycan biosynthesis - keratan sulfate 0.586956522 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Glycosaminoglycan degradation 0 0 -0.496010296 kegg kegg NA NA no no no no no up Vascular smooth muscle contraction Glyoxylate and dicarboxylate metabolism -0.692173913 -0.626482213 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction HIF-1 signaling pathway 0 0.455533597 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Histidine metabolism -0.539130435 0 -0.491119691 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Homologous recombination -0.419130435 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Inositol phosphate metabolism -0.507826087 -0.556324111 -0.41003861 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Lachnospira 0 0.506548076 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Vascular smooth muscle contraction MAPK signaling pathway 0 -0.720355731 -0.468211068 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Metabolism of xenobiotics by cytochrome P450 0 0.458498024 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Mitophagy - animal 0.79826087 0.660079051 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction mRNA surveillance pathway 0.563478261 0.423913043 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction mTOR signaling pathway 0 0.451581028 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Mucin type O-glycan biosynthesis 0 -0.503952569 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction N-Glycan biosynthesis 0 0.460474308 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Necroptosis 0.534782609 0 0.451737452 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction NF-kappa B signaling pathway -0.636521739 -0.722332016 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Nicotinate and nicotinamide metabolism -0.509565217 -0.576086957 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Nitrogen metabolism 0 -0.498023715 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Non-homologous end-joining -0.502608696 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Oocyte meiosis 0.417391304 0.440711462 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Oscillospira 0 -0.562252964 0 LPS-producing kegg Genus NA 0.62 no no no no no no Vascular smooth muscle contraction Other glycan degradation -0.510434783 -0.593873518 -0.51994852 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Oxidative phosphorylation 0.691304348 0.875494071 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Pantothenate and CoA biosynthesis -0.505217391 -0.58201581 0 kegg kegg NA NA no no no no no dn Vascular smooth muscle contraction Pentose and glucuronate interconversions 0 0.433794466 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Peroxisome -0.653913043 -0.633399209 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Phagosome -0.422608696 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Phosphatidylinositol signaling system 0.412173913 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Platinum drug resistance 0 -0.483201581 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Porphyrin and chlorophyll metabolism 0 0 0.437065637 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction PPAR signaling pathway 0 -0.627470356 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Proteasome 0 0.435770751 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Protein export 0.473913043 0.651185771 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Protein processing in endoplasmic reticulum 0.448695652 0.453557312 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Pyrimidine metabolism -0.566956522 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Pyruvate metabolism 0 0.447628458 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Rap1 signaling pathway 0 0.583992095 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Ras signaling pathway 0.413913043 0.565217391 0 yes kegg kegg NA NA no no no no up up Vascular smooth muscle contraction Retinol metabolism -0.496521739 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Ribosome 0.682608696 0.692687747 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction RNA degradation 0.569565217 0.472332016 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction SNARE interactions in vesicular transport -0.544347826 -0.664031621 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Starch and sucrose metabolism -0.554782609 -0.677865613 -0.464350064 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Steroid biosynthesis 0.439130435 0 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Taurine and hypotaurine metabolism 0 -0.506916996 0 kegg kegg NA NA no no no no no no Vascular smooth muscle contraction Tryptophan metabolism -0.46173913 0 0 kegg kegg NA NA no no no no up no Vascular smooth muscle contraction Ubiquitin mediated proteolysis 0.79826087 0.669960474 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption ABC transporters -0.567826087 0 0 kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption Adherens junction 0 0.558300395 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Adrenergic signaling in cardiomyocytes 0.709565217 0.804347826 0.691119691 kegg kegg NA NA no no no no no up Vasopressin-regulated water reabsorption AGE-RAGE signaling pathway in diabetic complications 0 -0.625494071 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption "Alanine, aspartate and glutamate metabolism" -0.60173913 -0.654150198 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Aldosterone synthesis and secretion 0.890434783 0.852766798 0.805148005 kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption alpha-Linolenic acid metabolism -0.589565217 -0.568181818 -0.554182754 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Amino sugar and nucleotide sugar metabolism -0.411304348 0 -0.41029601 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption AMPK signaling pathway 0 0.419960474 0.432947233 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Antigen processing and presentation -0.504347826 0 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Apelin signaling pathway 0 0.578063241 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Apoptosis 0 -0.570158103 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Arachidonic acid metabolism 0 0.423913043 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Arginine and proline metabolism -0.635652174 -0.601778656 0 kegg kegg NA NA no no no no up no Vasopressin-regulated water reabsorption Arginine biosynthesis -0.594782609 -0.597826087 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Ascorbate and aldarate metabolism 0 0 -0.56010296 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Autophagy - animal 0 -0.64229249 -0.589189189 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Autophagy - other 0 -0.433794466 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption B cell receptor signaling pathway 0 -0.616600791 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Biosynthesis of amino acids -0.546956522 -0.660079051 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Biosynthesis of cofactors 0 0.445652174 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption C-type lectin receptor signaling pathway 0 -0.68083004 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Calcium signaling pathway 0.653043478 0.798418972 0.601801802 kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption cAMP signaling pathway 0.499130435 0 0.481595882 yes kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption Carbon metabolism -0.425217391 0 -0.433976834 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Cardiac muscle contraction 0.569565217 0.757905138 0 kegg kegg NA NA no no no no no up Vasopressin-regulated water reabsorption Cell adhesion molecules 0 -0.565217391 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Cellular senescence 0 -0.468379447 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption cGMP-PKG signaling pathway 0 -0.577075099 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Circadian entrainment 0.73826087 0.793478261 0.87953668 kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption Citrate cycle (TCA cycle) 0 0 -0.406949807 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Complement and coagulation cascades -0.463478261 -0.527667984 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Coprococcus 0 0 -0.407748247 butyrate-producing kegg Genus NA 0.612 no no no no no no Vasopressin-regulated water reabsorption Cortisol synthesis and secretion 0.847826087 0.694664032 0.846589447 kegg kegg NA NA no no no no no up Vasopressin-regulated water reabsorption Cushing syndrome 0.854782609 0.666007905 0.675675676 kegg kegg NA NA no no no no no up Vasopressin-regulated water reabsorption Dopaminergic synapse 0.687826087 0.889328063 0.713256113 kegg kegg NA NA no no no no up no Vasopressin-regulated water reabsorption Drug metabolism - cytochrome P450 0 0.438735178 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Drug metabolism - other enzymes -0.420869565 0.422924901 -0.642213642 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption EGFR tyrosine kinase inhibitor resistance 0 0.483201581 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Endocrine and other factor-regulated calcium reabsorption 0.949565217 0.970355731 0.958301158 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Endocrine resistance 0.808695652 0.56916996 0.686229086 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Endocytosis 0 -0.528656126 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Estrogen signaling pathway 0 0 0.594851995 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Ether lipid metabolism 0.525217391 0 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Fatty acid biosynthesis -0.596521739 -0.67687747 -0.468983269 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Fatty acid degradation -0.686086957 -0.753952569 -0.618790219 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Fatty acid metabolism -0.686956522 -0.701581028 -0.496010296 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Fc epsilon RI signaling pathway 0 -0.641304348 -0.424195624 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Fc gamma R-mediated phagocytosis -0.52 -0.681818182 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Ferroptosis 0.429565217 0 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Focal adhesion 0 0.441699605 0 kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption FoxO signaling pathway 0 -0.564229249 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Fructose and mannose metabolism -0.504347826 0 -0.611325611 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption GABAergic synapse -0.503478261 0 0 kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption Galactose metabolism -0.493043478 -0.651185771 -0.685971686 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Gap junction 0.779130435 0.546442688 0.776061776 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Glucagon signaling pathway 0.726086957 0.813241107 0.574259974 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Glutamatergic synapse 0.57826087 0 0.610810811 kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption Glutathione metabolism 0 0.732213439 0.418532819 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Glycerolipid metabolism -0.407826087 0 -0.446074646 kegg kegg NA NA no no no no no up Vasopressin-regulated water reabsorption "Glycine, serine and threonine metabolism" 0 0.455533597 0 kegg kegg NA NA no no no no up no Vasopressin-regulated water reabsorption Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.5 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0 -0.407979408 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Glycosaminoglycan biosynthesis - keratan sulfate 0.547826087 0 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Glycosaminoglycan degradation 0 -0.494071146 -0.652767053 kegg kegg NA NA no no no no no up Vasopressin-regulated water reabsorption Glyoxylate and dicarboxylate metabolism -0.715652174 -0.631422925 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption GnRH signaling pathway 0.790434783 0.695652174 0.755727156 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption "Growth hormone synthesis, secretion and action" 0.432173913 0 0.436808237 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Hedgehog signaling pathway 0.432173913 0 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Hippo signaling pathway 0.434782609 0.533596838 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Hippo signaling pathway - multiple species 0 -0.564229249 -0.549292149 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Histidine metabolism 0 0 -0.534105534 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption IL-17 signaling pathway -0.405217391 -0.580039526 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Inflammatory mediator regulation of TRP channels 0.800869565 0.853754941 0.797940798 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Insulin resistance 0 -0.499011858 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Insulin secretion 0.840869565 0.740118577 0.787387387 yes kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption Insulin signaling pathway 0 0.493083004 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption JAK-STAT signaling pathway 0 -0.58201581 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Linoleic acid metabolism 0 0.456521739 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Long-term depression 0.86173913 0.543478261 0.810810811 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Longevity regulating pathway - multiple species 0 -0.4743083 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Lysosome 0 -0.490118577 -0.492664093 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption MAPK signaling pathway 0 -0.57312253 -0.53976834 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Melanogenesis 0.933043478 0.888339921 0.864350064 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Mitophagy - animal 0.57826087 0.658102767 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption mRNA surveillance pathway 0 0.53458498 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption mTOR signaling pathway 0 0.45256917 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Mucin type O-glycan biosynthesis 0 -0.511857708 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption N-Glycan biosynthesis 0 0.494071146 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Natural killer cell mediated cytotoxicity 0 -0.488142292 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Necroptosis 0.554782609 0.414031621 0.432689833 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Neuroactive ligand-receptor interaction 0 -0.611660079 0 kegg kegg NA NA no no no up up up Vasopressin-regulated water reabsorption Neurotrophin signaling pathway 0 -0.5 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Neutrophil extracellular trap formation -0.436521739 -0.500988142 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption NF-kappa B signaling pathway -0.600869565 -0.616600791 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Nicotinate and nicotinamide metabolism -0.648695652 -0.583003953 -0.442985843 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Nitrogen metabolism -0.469565217 -0.451581028 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption NOD-like receptor signaling pathway -0.712173913 -0.79743083 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Non-alcoholic fatty liver disease 0.577391304 0.743083004 0.558558559 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Notch signaling pathway 0 0 -0.422136422 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Olfactory transduction 0 -0.472332016 -0.436550837 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Oscillospira 0 -0.511857708 0 LPS-producing kegg Genus NA 0.62 no no no no no no Vasopressin-regulated water reabsorption Osteoclast differentiation -0.619130435 -0.779644269 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Other glycan degradation -0.579130435 -0.425889328 -0.485714286 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Ovarian steroidogenesis 0.88173913 0.781620553 0.831402831 kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption Oxidative phosphorylation 0.542608696 0.754940711 0.411583012 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Pantothenate and CoA biosynthesis -0.454782609 -0.656126482 -0.546203346 kegg kegg NA NA no no no no no dn Vasopressin-regulated water reabsorption "Parathyroid hormone synthesis, secretion and action" 0.628695652 0.735177866 0.668725869 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Pentose phosphate pathway 0 -0.558300395 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Peroxisome -0.744347826 -0.767786561 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Phagosome 0 -0.510869565 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Platelet activation 0.46173913 0.572134387 0.47027027 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption PPAR signaling pathway -0.513913043 -0.77173913 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Prolactin signaling pathway 0 -0.599802372 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Proteasome 0 0 -0.496010296 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Protein export 0 0.492094862 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Protein processing in endoplasmic reticulum 0 0.527667984 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Purine metabolism 0 0.460474308 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Pyrimidine metabolism -0.524347826 0.43972332 -0.521235521 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Rap1 signaling pathway 0 0.470355731 0.410810811 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Ras signaling pathway 0 0.519762846 0 yes kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption Regulation of lipolysis in adipocytes 0.823478261 0.81027668 0.879279279 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Relaxin signaling pathway 0 0 0.43989704 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Renin secretion 0.783478261 0.87055336 0.884942085 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Renin-angiotensin system 0 -0.605731225 -0.43963964 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Retrograde endocannabinoid signaling 0 0.793478261 0 kegg kegg NA NA no no no no no up Vasopressin-regulated water reabsorption Ribosome 0.431304348 0.662055336 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption RIG-I-like receptor signaling pathway -0.492173913 -0.627470356 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption RNA degradation 0 0.561264822 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption RNA polymerase 0 0.462450593 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Serotonergic synapse 0.520869565 0.420948617 0.548519949 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption SNARE interactions in vesicular transport -0.556521739 -0.587944664 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Sphingolipid metabolism 0 0 -0.540797941 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Sphingolipid signaling pathway 0 -0.509881423 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Starch and sucrose metabolism -0.556521739 -0.691699605 -0.690862291 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Steroid biosynthesis 0.45826087 0 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Steroid hormone biosynthesis 0 0 -0.501673102 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Synaptic vesicle cycle 0 -0.517786561 -0.516344916 kegg kegg NA NA no no no no up up Vasopressin-regulated water reabsorption T cell receptor signaling pathway 0 -0.644268775 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption TGF-beta signaling pathway 0 0.483201581 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Th1 and Th2 cell differentiation 0 -0.591897233 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Th17 cell differentiation 0 -0.656126482 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Thermogenesis 0.645217391 0.756916996 0.45997426 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Thyroid hormone signaling pathway 0.412173913 0.639328063 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Thyroid hormone synthesis 0.688695652 0.849802372 0.732561133 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption TNF signaling pathway 0 -0.527667984 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Toll-like receptor signaling pathway 0 -0.634387352 0 yes kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Tryptophan metabolism 0 0 -0.436036036 kegg kegg NA NA no no no no up no Vasopressin-regulated water reabsorption Type I diabetes mellitus 0 -0.438735178 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Type II diabetes mellitus 0 -0.42687747 -0.58996139 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Ubiquitin mediated proteolysis 0.633913043 0.695652174 0 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Vascular smooth muscle contraction 0.735652174 0.825098814 0.729214929 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Viral protein interaction with cytokine and cytokine receptor 0 0 0.42960103 kegg kegg NA NA no no no no no no Vasopressin-regulated water reabsorption Wnt signaling pathway 0.571304348 0.563241107 0 kegg kegg NA NA no no no no no no VEGF signaling pathway 2-Oxocarboxylic acid metabolism -0.605217391 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Adrenergic signaling in cardiomyocytes 0.423478261 0 0 kegg kegg NA NA no no no no no up VEGF signaling pathway alpha-Linolenic acid metabolism -0.449565217 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Amino sugar and nucleotide sugar metabolism -0.705217391 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Aminoacyl-tRNA biosynthesis -0.507826087 -0.441699605 0 kegg kegg NA NA no no no no no no VEGF signaling pathway AMPK signaling pathway 0 0 -0.571943372 kegg kegg NA NA no no no no no no VEGF signaling pathway Antifolate resistance -0.460869565 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Apoptosis 0 0.558300395 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Arachidonic acid metabolism -0.748695652 0 -0.626512227 kegg kegg NA NA no no no no no no VEGF signaling pathway Arginine and proline metabolism 0 0.519762846 0 kegg kegg NA NA no no no no up no VEGF signaling pathway Arginine biosynthesis 0 0.418972332 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Ascorbate and aldarate metabolism -0.417391304 -0.555335968 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Autophagy - animal 0.545217391 0.567193676 0.516602317 kegg kegg NA NA no no no no no no VEGF signaling pathway Autophagy - other 0 0 0.55984556 kegg kegg NA NA no no no no no no VEGF signaling pathway Axon guidance 0.666956522 0 0.564993565 kegg kegg NA NA no no no no up up VEGF signaling pathway Basal transcription factors 0 -0.451581028 0 kegg kegg NA NA no no no no no no VEGF signaling pathway beta-Alanine metabolism -0.64173913 -0.581027668 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Biosynthesis of cofactors -0.737391304 -0.462450593 -0.593050193 kegg kegg NA NA no no no no no no VEGF signaling pathway Biosynthesis of unsaturated fatty acids -0.450434783 -0.548418972 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Butanoate metabolism -0.682608696 -0.605731225 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Butyricimonas 0.47822921 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no VEGF signaling pathway Calcium signaling pathway 0.533043478 0 0 kegg kegg NA NA no no no no up up VEGF signaling pathway cAMP signaling pathway 0.628695652 0.446640316 0 yes kegg kegg NA NA no no no no up up VEGF signaling pathway Carbon metabolism -0.570434783 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Cellular senescence 0 0.532608696 0 kegg kegg NA NA no no no no no no VEGF signaling pathway cGMP-PKG signaling pathway 0.6 0.421936759 0.548519949 kegg kegg NA NA no no no no no no VEGF signaling pathway Chemokine signaling pathway 0.486086957 0.62944664 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Citrate cycle (TCA cycle) -0.54 -0.686758893 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Cysteine and methionine metabolism -0.455652174 -0.583003953 0 kegg kegg NA NA no no no no no no VEGF signaling pathway DNA replication 0 -0.562252964 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Dorea -0.44 0 0 kegg Genus NA 0.00362 no no no up no dn VEGF signaling pathway Drug metabolism - cytochrome P450 -0.540869565 -0.640316206 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Drug metabolism - other enzymes -0.706086957 -0.570158103 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Endocytosis 0 0.415019763 0 kegg kegg NA NA no no no no no no VEGF signaling pathway ErbB signaling pathway 0.816521739 0.813241107 0.780694981 kegg kegg NA NA no no no no no no VEGF signaling pathway Ether lipid metabolism 0 -0.484189723 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Fatty acid biosynthesis 0 0.449604743 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Fatty acid elongation -0.459130435 -0.445652174 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Ferroptosis 0 0 -0.54002574 kegg kegg NA NA no no no no no no VEGF signaling pathway Folate biosynthesis 0 0 0.406177606 kegg kegg NA NA no no no no no no VEGF signaling pathway Fructose and mannose metabolism -0.633043478 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Galactose metabolism -0.491304348 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Glutathione metabolism -0.647826087 0 -0.751608752 kegg kegg NA NA no no no no no no VEGF signaling pathway Glycerolipid metabolism 0 0 0.498069498 kegg kegg NA NA no no no no no up VEGF signaling pathway Glycerophospholipid metabolism 0 0 0.488545689 kegg kegg NA NA no no no no no up VEGF signaling pathway "Glycine, serine and threonine metabolism" -0.533913043 0 -0.553667954 kegg kegg NA NA no no no no up no VEGF signaling pathway Glycolysis / Gluconeogenesis -0.709565217 -0.542490119 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0.665019763 0.584555985 kegg kegg NA NA no no no no no no VEGF signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.405217391 0 0.503217503 kegg kegg NA NA no no no no no no VEGF signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0.429565217 0 0.531531532 kegg kegg NA NA no no no no no no VEGF signaling pathway Glycosaminoglycan degradation 0 0 0.520978121 kegg kegg NA NA no no no no no up VEGF signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.56173913 0 0.497554698 kegg kegg NA NA no no no no no no VEGF signaling pathway Glyoxylate and dicarboxylate metabolism 0 0.43083004 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Hedgehog signaling pathway 0.554782609 0 0.546718147 kegg kegg NA NA no no no no no no VEGF signaling pathway Histidine metabolism -0.470434783 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Inositol phosphate metabolism 0 0 0.448391248 kegg kegg NA NA no no no no no no VEGF signaling pathway Linoleic acid metabolism -0.559130435 0 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Longevity regulating pathway 0 0 -0.468211068 kegg kegg NA NA no no no no no no VEGF signaling pathway Lysine degradation 0 0 0.490604891 kegg kegg NA NA no no no no no no VEGF signaling pathway Mannose type O-glycan biosynthesis 0.454782609 0 0.50990991 kegg kegg NA NA no no no no no no VEGF signaling pathway MAPK signaling pathway 0 0 0.763706564 kegg kegg NA NA no no no no no no VEGF signaling pathway Metabolism of xenobiotics by cytochrome P450 -0.58 -0.67687747 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Mismatch repair -0.517391304 -0.566205534 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Mitophagy - animal 0 0 -0.595366795 kegg kegg NA NA no no no no no no VEGF signaling pathway mRNA surveillance pathway 0.467826087 0 0.473616474 kegg kegg NA NA no no no no no no VEGF signaling pathway N-Glycan biosynthesis 0 -0.427865613 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Necroptosis 0 0 -0.526383526 kegg kegg NA NA no no no no no no VEGF signaling pathway NF-kappa B signaling pathway 0 0.562252964 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Nicotinate and nicotinamide metabolism 0 0.505928854 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Nitrogen metabolism 0 0.461462451 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Non-homologous end-joining -0.549565217 -0.441699605 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Notch signaling pathway 0.653043478 0.432806324 0.682110682 kegg kegg NA NA no no no no no no VEGF signaling pathway Nucleotide excision repair 0 -0.566205534 0 kegg kegg NA NA no no no no no no VEGF signaling pathway One carbon pool by folate 0 -0.480237154 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Oocyte meiosis 0 -0.515810277 0.420592021 kegg kegg NA NA no no no no no no VEGF signaling pathway Other glycan degradation 0 0 0.417760618 kegg kegg NA NA no no no no no no VEGF signaling pathway Other types of O-glycan biosynthesis 0 0 0.445045045 kegg kegg NA NA no no no no no no VEGF signaling pathway Pentose and glucuronate interconversions -0.610434783 -0.640316206 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Phenylalanine metabolism -0.590434783 -0.541501976 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Phosphatidylinositol signaling system 0.606086957 0 0.636293436 kegg kegg NA NA no no no no no no VEGF signaling pathway Phospholipase D signaling pathway 0.588695652 0.630434783 0 kegg kegg NA NA no no no no up up VEGF signaling pathway Porphyrin and chlorophyll metabolism -0.579130435 0 -0.62033462 kegg kegg NA NA no no no no no no VEGF signaling pathway PPAR signaling pathway 0 0.509881423 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Primary bile acid biosynthesis -0.533043478 -0.593873518 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Propanoate metabolism -0.528695652 -0.591897233 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Proteasome 0 -0.639328063 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Protein export 0 -0.498023715 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Protein processing in endoplasmic reticulum 0 -0.471343874 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Purine metabolism -0.42173913 0 -0.481595882 kegg kegg NA NA no no no no no no VEGF signaling pathway Pyrimidine metabolism -0.622608696 -0.432806324 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Pyruvate metabolism -0.54 -0.647233202 -0.474131274 kegg kegg NA NA no no no no no no VEGF signaling pathway Ras signaling pathway 0.43826087 0 0.607722008 yes kegg kegg NA NA no no no no up up VEGF signaling pathway Retinol metabolism -0.51826087 -0.499011858 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Ribosome 0 -0.421936759 0 kegg kegg NA NA no no no no no no VEGF signaling pathway RNA degradation 0.473043478 0 0.474903475 kegg kegg NA NA no no no no no no VEGF signaling pathway RNA polymerase 0 -0.501976285 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Sphingolipid signaling pathway 0.884347826 0.640316206 0.833204633 kegg kegg NA NA no no no no no no VEGF signaling pathway Steroid biosynthesis 0 -0.713438735 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Steroid hormone biosynthesis -0.590434783 -0.578063241 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Sulfur metabolism -0.610434783 0 -0.577606178 kegg kegg NA NA no no no no no no VEGF signaling pathway Synthesis and degradation of ketone bodies -0.429565217 -0.589920949 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Terpenoid backbone biosynthesis 0 -0.446640316 0 kegg kegg NA NA no no no no no no VEGF signaling pathway TGF-beta signaling pathway 0 -0.460474308 0.560617761 kegg kegg NA NA no no no no no no VEGF signaling pathway Thiamine metabolism -0.435652174 -0.531620553 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Tryptophan metabolism -0.653913043 -0.660079051 0 kegg kegg NA NA no no no no up no VEGF signaling pathway Tyrosine metabolism -0.665217391 -0.605731225 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis -0.66173913 -0.563241107 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Ubiquitin mediated proteolysis 0 -0.46541502 -0.602059202 kegg kegg NA NA no no no no no no VEGF signaling pathway "Valine, leucine and isoleucine degradation" -0.634782609 -0.653162055 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Vascular smooth muscle contraction 0 -0.460474308 0 kegg kegg NA NA no no no no no no VEGF signaling pathway Wnt signaling pathway 0.473043478 0 0.673101673 kegg kegg NA NA no no no no no no Vibrio cholerae infection ABC transporters 0 -0.565217391 0 kegg kegg NA NA no no no no up up Vibrio cholerae infection Adherens junction 0.947826087 0.922924901 0.867696268 kegg kegg NA NA no no no no no no Vibrio cholerae infection Adipocytokine signaling pathway 0 -0.445652174 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Adrenergic signaling in cardiomyocytes 0 0.459486166 0 kegg kegg NA NA no no no no no up Vibrio cholerae infection AGE-RAGE signaling pathway in diabetic complications -0.428695652 -0.530632411 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection "Alanine, aspartate and glutamate metabolism" 0 -0.612648221 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Alistipes 0 -0.507183328 0 kegg Genus NA 0.0114 no no no no up no Vibrio cholerae infection Alzheimer disease 0 0.615612648 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Amphetamine addiction 0 0.432806324 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Amyotrophic lateral sclerosis 0 0.624505929 0.51016731 kegg kegg NA NA no no no no no no Vibrio cholerae infection Apelin signaling pathway -0.409565217 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Apoptosis 0 0 0.504504505 kegg kegg NA NA no no no no no no Vibrio cholerae infection Apoptosis - multiple species -0.733913043 -0.634387352 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Arginine and proline metabolism 0 -0.520750988 0 kegg kegg NA NA no no no no up no Vibrio cholerae infection Arginine biosynthesis 0 -0.540513834 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Autophagy - animal -0.704347826 -0.824110672 -0.611068211 kegg kegg NA NA no no no no no no Vibrio cholerae infection Autophagy - other -0.819130435 -0.840909091 -0.683655084 kegg kegg NA NA no no no no no no Vibrio cholerae infection Axon guidance 0 0 -0.43963964 kegg kegg NA NA no no no no up up Vibrio cholerae infection B cell receptor signaling pathway 0 -0.460474308 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Bacterial invasion of epithelial cells 0.820869565 0.83201581 0.776576577 kegg kegg NA NA no no no no no no Vibrio cholerae infection Basal transcription factors -0.668695652 0 -0.52972973 kegg kegg NA NA no no no no no no Vibrio cholerae infection Base excision repair -0.735652174 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Bifidobacterium 0 0.445271301 0 acetate-producing kegg Genus NA 0.105 no no no no dn no Vibrio cholerae infection Bile secretion 0.54 0.641304348 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection C-type lectin receptor signaling pathway -0.468695652 -0.571146245 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Calcium signaling pathway 0 0.545454545 0 kegg kegg NA NA no no no no up up Vibrio cholerae infection Carbohydrate digestion and absorption -0.55826087 -0.451581028 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Cardiac muscle contraction 0 0.630434783 0.445817246 kegg kegg NA NA no no no no no up Vibrio cholerae infection Cell cycle -0.42173913 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Cholinergic synapse -0.462608696 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Circadian entrainment 0.492173913 0.743083004 0 kegg kegg NA NA no no no no up up Vibrio cholerae infection Circadian rhythm -0.484347826 0 -0.554440154 kegg kegg NA NA no no no no no no Vibrio cholerae infection Collecting duct acid secretion 0.439130435 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Cytokine-cytokine receptor interaction 0 0 0.541312741 kegg kegg NA NA no no no no no no Vibrio cholerae infection Dopaminergic synapse 0 0.609683794 0 kegg kegg NA NA no no no no up no Vibrio cholerae infection Drug metabolism - cytochrome P450 0 0.52173913 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Drug metabolism - other enzymes 0 0.612648221 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection EGFR tyrosine kinase inhibitor resistance -0.459130435 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Endocrine and other factor-regulated calcium reabsorption 0.454782609 0.593873518 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection ErbB signaling pathway -0.456521739 -0.564229249 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Fanconi anemia pathway -0.436521739 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Fatty acid biosynthesis 0 -0.535573123 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Fatty acid degradation 0 -0.589920949 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Fatty acid metabolism 0 -0.523715415 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Fc epsilon RI signaling pathway 0 -0.41798419 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Focal adhesion 0.82 0.862648221 0.652252252 kegg kegg NA NA no no no no up up Vibrio cholerae infection FoxO signaling pathway -0.44 -0.754940711 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection GABAergic synapse -0.417391304 -0.449604743 0 kegg kegg NA NA no no no no up up Vibrio cholerae infection Gap junction 0.497391304 0 0.415186615 kegg kegg NA NA no no no no no no Vibrio cholerae infection Gastric acid secretion 0.969565217 0.96541502 0.946718147 kegg kegg NA NA no no no no no no Vibrio cholerae infection Glucagon signaling pathway 0 0.418972332 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Glutathione metabolism 0 0.457509881 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Glycerolipid metabolism 0 -0.552371542 0 kegg kegg NA NA no no no no no up Vibrio cholerae infection Glycerophospholipid metabolism -0.413913043 -0.517786561 0 kegg kegg NA NA no no no no no up Vibrio cholerae infection Glycolysis / Gluconeogenesis 0 0.444664032 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.56027668 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.453913043 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.407826087 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Glyoxylate and dicarboxylate metabolism 0 -0.552371542 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection GnRH secretion 0 -0.517786561 0 kegg kegg NA NA no no no no up up Vibrio cholerae infection HIF-1 signaling pathway -0.57826087 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Hippo signaling pathway 0.873043478 0.831027668 0.717631918 kegg kegg NA NA no no no no no no Vibrio cholerae infection Hippo signaling pathway - multiple species 0 -0.483201581 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Homologous recombination -0.453913043 -0.466403162 -0.432175032 kegg kegg NA NA no no no no no no Vibrio cholerae infection Huntington disease 0 0.625494071 0.433976834 kegg kegg NA NA no no no no no no Vibrio cholerae infection Inflammatory mediator regulation of TRP channels 0 0.56916996 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Inositol phosphate metabolism 0 -0.593873518 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Insulin resistance -0.634782609 -0.606719368 -0.485456885 kegg kegg NA NA no no no no no no Vibrio cholerae infection Insulin signaling pathway -0.484347826 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection JAK-STAT signaling pathway 0 -0.703557312 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Lachnospira 0 0.630096387 0 butyrate-producing kegg Genus NA 0.279 no no no no no no Vibrio cholerae infection Leukocyte transendothelial migration 0.71826087 0.587944664 0.653539254 kegg kegg NA NA no no no no no no Vibrio cholerae infection Long-term depression 0.413043478 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Long-term potentiation -0.407826087 0 0 kegg kegg NA NA no no no no no up Vibrio cholerae infection Lysine degradation -0.553043478 0 -0.431917632 kegg kegg NA NA no no no no no no Vibrio cholerae infection MAPK signaling pathway 0 -0.672924901 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Melanogenesis 0.497391304 0.598814229 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Metabolism of xenobiotics by cytochrome P450 0 0.554347826 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Morphine addiction 0.422608696 0.601778656 0 kegg kegg NA NA no no no no up up Vibrio cholerae infection mTOR signaling pathway -0.436521739 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Mucin type O-glycan biosynthesis 0 -0.734189723 -0.502187902 kegg kegg NA NA no no no no no no Vibrio cholerae infection Neurotrophin signaling pathway 0 -0.486166008 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Neutrophil extracellular trap formation 0 0 0.463063063 kegg kegg NA NA no no no no no no Vibrio cholerae infection NF-kappa B signaling pathway -0.530434783 -0.671936759 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Nicotinate and nicotinamide metabolism 0 -0.436758893 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Nitrogen metabolism 0 -0.505928854 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection NOD-like receptor signaling pathway 0 -0.678853755 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Non-alcoholic fatty liver disease 0 0.551383399 0.483655084 kegg kegg NA NA no no no no no no Vibrio cholerae infection Oscillospira 0 -0.473320158 0 LPS-producing kegg Genus NA 0.62 no no no no no no Vibrio cholerae infection Osteoclast differentiation 0 -0.482213439 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Other glycan degradation 0 -0.479249012 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Other types of O-glycan biosynthesis -0.504347826 0 -0.438352638 kegg kegg NA NA no no no no no no Vibrio cholerae infection Ovarian steroidogenesis 0.58173913 0 0 kegg kegg NA NA no no no no up up Vibrio cholerae infection Oxidative phosphorylation 0 0.634387352 0.49034749 kegg kegg NA NA no no no no no no Vibrio cholerae infection Oxytocin signaling pathway 0.875652174 0.827075099 0.743371943 kegg kegg NA NA no no no no no no Vibrio cholerae infection p53 signaling pathway -0.753913043 -0.575098814 -0.536164736 kegg kegg NA NA no no no no no no Vibrio cholerae infection Pancreatic secretion 0 0.716403162 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Pantothenate and CoA biosynthesis 0 -0.460474308 0 kegg kegg NA NA no no no no no dn Vibrio cholerae infection "Parathyroid hormone synthesis, secretion and action" 0 0.421936759 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Parkinson disease 0 0.572134387 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Pathways of neurodegeneration - multiple diseases 0 0.537549407 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Peroxisome 0 -0.552371542 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Phagosome 0 0 0.503732304 kegg kegg NA NA no no no no no no Vibrio cholerae infection Phenylalanine metabolism 0.597391304 0.531620553 0.489060489 kegg kegg NA NA no no no no no no Vibrio cholerae infection Phototransduction 0 0.504940711 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection PI3K-Akt signaling pathway -0.454782609 0 0 yes kegg kegg NA NA no no no no up up Vibrio cholerae infection Platelet activation 0.955652174 0.95256917 0.888545689 kegg kegg NA NA no no no no no no Vibrio cholerae infection Platinum drug resistance -0.768695652 -0.603754941 -0.447876448 kegg kegg NA NA no no no no no no Vibrio cholerae infection PPAR signaling pathway 0 -0.552371542 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Prion disease 0 0.595849802 0.457915058 kegg kegg NA NA no no no no no no Vibrio cholerae infection Progesterone-mediated oocyte maturation -0.620869565 -0.584980237 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Prolactin signaling pathway 0 -0.421936759 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Proteasome -0.524347826 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Protein digestion and absorption 0 -0.564229249 0 yes kegg kegg NA NA no no no no up up Vibrio cholerae infection Protein export -0.489565217 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Rap1 signaling pathway 0.904347826 0.899209486 0.9001287 kegg kegg NA NA no no no no no no Vibrio cholerae infection Ras signaling pathway 0 0.438735178 0 yes kegg kegg NA NA no no no no up up Vibrio cholerae infection Regulation of actin cytoskeleton 0.664347826 0.577075099 0.497812098 kegg kegg NA NA no no no no no no Vibrio cholerae infection Renin secretion 0.508695652 0.693675889 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Retrograde endocannabinoid signaling 0 0.647233202 0 kegg kegg NA NA no no no no no up Vibrio cholerae infection Ribosome 0 0.472332016 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Ribosome biogenesis in eukaryotes -0.592173913 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection RIG-I-like receptor signaling pathway -0.612173913 -0.709486166 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection RNA degradation 0 0 -0.403861004 kegg kegg NA NA no no no no no no Vibrio cholerae infection RNA polymerase -0.647826087 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection RNA transport -0.503478261 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Salivary secretion 0.497391304 0.647233202 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Selenocompound metabolism -0.677391304 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Serotonergic synapse 0.407826087 0 0.433719434 kegg kegg NA NA no no no no no no Vibrio cholerae infection Signaling pathways regulating pluripotency of stem cells 0 -0.46541502 -0.404633205 kegg kegg NA NA no no no no no no Vibrio cholerae infection SNARE interactions in vesicular transport 0 -0.687747036 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Spinocerebellar ataxia -0.754782609 0 -0.436808237 kegg kegg NA NA no no no no no no Vibrio cholerae infection Spliceosome -0.793043478 -0.627470356 -0.505276705 kegg kegg NA NA no no no no no no Vibrio cholerae infection Starch and sucrose metabolism 0 -0.453557312 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection T cell receptor signaling pathway 0 -0.827075099 -0.569111969 kegg kegg NA NA no no no no no no Vibrio cholerae infection Taurine and hypotaurine metabolism 0 -0.502964427 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Terpenoid backbone biosynthesis -0.426956522 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Thermogenesis 0 0.624505929 0.480566281 kegg kegg NA NA no no no no no no Vibrio cholerae infection Thiamine metabolism 0 0 -0.427541828 kegg kegg NA NA no no no no no no Vibrio cholerae infection Thyroid hormone signaling pathway 0.813913043 0.896245059 0.744144144 kegg kegg NA NA no no no no no no Vibrio cholerae infection Tight junction 0.787826087 0.834980237 0.696525097 kegg kegg NA NA no no no no no no Vibrio cholerae infection TNF signaling pathway 0 -0.571146245 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Toll-like receptor signaling pathway 0 -0.492094862 0 yes kegg kegg NA NA no no no no no no Vibrio cholerae infection Type II diabetes mellitus -0.411304348 -0.644268775 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Tyrosine metabolism 0 0.436758893 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Various types of N-glycan biosynthesis -0.53826087 0 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Vascular smooth muscle contraction 0 0.741106719 0 kegg kegg NA NA no no no no no no Vibrio cholerae infection Vasopressin-regulated water reabsorption 0.506086957 0.678853755 0.414929215 kegg kegg NA NA no no no no no no Vibrio cholerae infection Viral protein interaction with cytokine and cytokine receptor 0 0 0.448391248 kegg kegg NA NA no no no no no no Viral carcinogenesis Adrenergic signaling in cardiomyocytes 0 -0.508893281 0 kegg kegg NA NA no no no no no up Viral carcinogenesis AGE-RAGE signaling pathway in diabetic complications 0 0.56027668 0 kegg kegg NA NA no no no no no no Viral carcinogenesis "Alanine, aspartate and glutamate metabolism" 0 0.415019763 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Aldosterone synthesis and secretion 0 -0.65513834 0 kegg kegg NA NA no no no no up up Viral carcinogenesis Aldosterone-regulated sodium reabsorption 0 0.520750988 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Alzheimer disease 0 -0.505928854 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Amino sugar and nucleotide sugar metabolism 0 0 -0.620592021 kegg kegg NA NA no no no no no no Viral carcinogenesis Amoebiasis 0.459130435 0.517786561 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Amphetamine addiction -0.449565217 -0.817193676 0 kegg kegg NA NA no no no no no no Viral carcinogenesis AMPK signaling pathway 0 -0.530632411 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Amyotrophic lateral sclerosis 0 -0.551383399 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Antifolate resistance 0 0 -0.401287001 kegg kegg NA NA no no no no no no Viral carcinogenesis Antigen processing and presentation 0.508695652 0 0.451737452 kegg kegg NA NA no no no no no no Viral carcinogenesis Apelin signaling pathway 0 -0.51284585 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Apoptosis 0.54173913 0.839920949 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Apoptosis - multiple species 0 0 -0.577091377 kegg kegg NA NA no no no no no no Viral carcinogenesis Arginine and proline metabolism 0 0.472332016 0 kegg kegg NA NA no no no no up no Viral carcinogenesis Arginine biosynthesis 0 0.449604743 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Ascorbate and aldarate metabolism -0.420869565 0 -0.486743887 kegg kegg NA NA no no no no no no Viral carcinogenesis Autophagy - animal 0 0.480237154 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Axon guidance 0 0.422924901 0 kegg kegg NA NA no no no no up up Viral carcinogenesis B cell receptor signaling pathway 0 0.70256917 0.502960103 kegg kegg NA NA no no no no no no Viral carcinogenesis Basal transcription factors -0.673043478 -0.617588933 -0.505791506 kegg kegg NA NA no no no no no no Viral carcinogenesis Base excision repair -0.431304348 -0.497035573 -0.57992278 kegg kegg NA NA no no no no no no Viral carcinogenesis beta-Alanine metabolism 0 0 -0.482882883 kegg kegg NA NA no no no no no no Viral carcinogenesis Biosynthesis of amino acids 0.52 0.64229249 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Biosynthesis of cofactors 0 -0.854743083 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Biosynthesis of unsaturated fatty acids 0 0 -0.531016731 kegg kegg NA NA no no no no no no Viral carcinogenesis Butanoate metabolism 0 -0.533596838 -0.507850708 kegg kegg NA NA no no no no no no Viral carcinogenesis C-type lectin receptor signaling pathway 0 0.778656126 0.494723295 kegg kegg NA NA no no no no no no Viral carcinogenesis cAMP signaling pathway 0 0.41798419 0 yes kegg kegg NA NA no no no no up up Viral carcinogenesis Carbohydrate digestion and absorption 0 0.481225296 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Cardiac muscle contraction 0 -0.428853755 0 kegg kegg NA NA no no no no no up Viral carcinogenesis Cell adhesion molecules 0.844347826 0.90513834 0.794079794 kegg kegg NA NA no no no no no no Viral carcinogenesis Cell cycle -0.61826087 -0.654150198 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Cellular senescence 0.935652174 0.976284585 0.964221364 kegg kegg NA NA no no no no no no Viral carcinogenesis cGMP-PKG signaling pathway 0 0.605731225 0.402831403 kegg kegg NA NA no no no no no no Viral carcinogenesis Chagas disease 0 0.597826087 0.652767053 kegg kegg NA NA no no no no no no Viral carcinogenesis Chemokine signaling pathway 0.508695652 0.603754941 0.553410553 kegg kegg NA NA no no no no no no Viral carcinogenesis Cholesterol metabolism 0 0.608695652 0 yes kegg kegg NA NA no no no no no up Viral carcinogenesis Circadian entrainment 0 -0.615612648 0 kegg kegg NA NA no no no no up up Viral carcinogenesis Circadian rhythm 0 -0.425889328 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Citrate cycle (TCA cycle) 0 -0.532608696 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Complement and coagulation cascades 0.626086957 0.603754941 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Coronavirus disease - COVID-19 0 -0.420948617 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Cortisol synthesis and secretion 0 -0.500988142 0 kegg kegg NA NA no no no no no up Viral carcinogenesis Cushing syndrome 0 -0.590909091 0 kegg kegg NA NA no no no no no up Viral carcinogenesis Cysteine and methionine metabolism 0 -0.538537549 -0.432689833 kegg kegg NA NA no no no no no no Viral carcinogenesis Cytosolic DNA-sensing pathway 0.409565217 0.517786561 0.651994852 kegg kegg NA NA no no no no no no Viral carcinogenesis DNA replication -0.50173913 -0.621541502 -0.466666667 kegg kegg NA NA no no no no no no Viral carcinogenesis Dopaminergic synapse 0 -0.666007905 0 kegg kegg NA NA no no no no up no Viral carcinogenesis Drug metabolism - cytochrome P450 0 -0.549407115 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Endocrine and other factor-regulated calcium reabsorption 0 -0.539525692 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Endocrine resistance 0 -0.419960474 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Endocytosis 0.915652174 0.916007905 0.92020592 kegg kegg NA NA no no no no no no Viral carcinogenesis Epithelial cell signaling in Helicobacter pylori infection 0.593043478 0.760869565 0.743629344 kegg kegg NA NA no no no no no no Viral carcinogenesis Epstein-Barr virus infection 0.544347826 0 0.661003861 kegg kegg NA NA no no no no no no Viral carcinogenesis Estrogen signaling pathway -0.444347826 -0.717391304 -0.407464607 kegg kegg NA NA no no no no no no Viral carcinogenesis Ether lipid metabolism -0.494782609 -0.756916996 -0.476447876 kegg kegg NA NA no no no no no no Viral carcinogenesis Fanconi anemia pathway -0.504347826 -0.552371542 -0.53976834 kegg kegg NA NA no no no no no no Viral carcinogenesis Fatty acid biosynthesis 0 0.469367589 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Fatty acid elongation 0 0 -0.450965251 kegg kegg NA NA no no no no no no Viral carcinogenesis Fc epsilon RI signaling pathway 0 0.753952569 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Fc gamma R-mediated phagocytosis 0 0.576086957 0 kegg kegg NA NA no no no no no no Viral carcinogenesis FoxO signaling pathway 0 0 -0.495495495 kegg kegg NA NA no no no no no no Viral carcinogenesis Galactose metabolism 0 0.455533597 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Glucagon signaling pathway 0 -0.730237154 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Glutathione metabolism 0 -0.64229249 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Glycerophospholipid metabolism -0.489565217 0 0 kegg kegg NA NA no no no no no up Viral carcinogenesis "Glycine, serine and threonine metabolism" 0 -0.731225296 0 kegg kegg NA NA no no no no up no Viral carcinogenesis Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.484347826 0.552371542 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Glycosaminoglycan degradation 0 0.509881423 0 kegg kegg NA NA no no no no no up Viral carcinogenesis Glycosphingolipid biosynthesis - ganglio series -0.466956522 0 -0.415958816 kegg kegg NA NA no no no no no no Viral carcinogenesis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.665019763 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Glyoxylate and dicarboxylate metabolism 0 0.491106719 0 kegg kegg NA NA no no no no no no Viral carcinogenesis GnRH signaling pathway 0 -0.476284585 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Hedgehog signaling pathway -0.434782609 -0.427865613 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Hepatitis B 0 0.540513834 0.431402831 kegg kegg NA NA no no no no no no Viral carcinogenesis Hepatitis C 0 0.595849802 0.437065637 kegg kegg NA NA no no no no no no Viral carcinogenesis Herpes simplex virus 1 infection 0.442608696 0 0.536422136 kegg kegg NA NA no no no no no no Viral carcinogenesis Histidine metabolism 0 0 -0.475418275 kegg kegg NA NA no no no no no no Viral carcinogenesis Homologous recombination 0 0 -0.624967825 kegg kegg NA NA no no no no no no Viral carcinogenesis Human cytomegalovirus infection 0.540869565 0.455533597 0.665122265 kegg kegg NA NA no no no no no dn Viral carcinogenesis Human immunodeficiency virus 1 infection 0.473913043 0.432806324 0.633719434 kegg kegg NA NA no no no no no no Viral carcinogenesis Human papillomavirus infection 0.934782609 0.957509881 0.958301158 kegg kegg NA NA no no no no no no Viral carcinogenesis Human T-cell leukemia virus 1 infection 0.53826087 0 0.571943372 kegg kegg NA NA no no no no no no Viral carcinogenesis Huntington disease 0 -0.516798419 0 kegg kegg NA NA no no no no no no Viral carcinogenesis IL-17 signaling pathway 0 0.616600791 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Inflammatory mediator regulation of TRP channels 0 -0.574110672 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Influenza A 0.420869565 0.640316206 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Insulin resistance 0 0.518774704 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Insulin secretion 0 -0.461462451 0 yes kegg kegg NA NA no no no no up up Viral carcinogenesis Insulin signaling pathway 0 -0.466403162 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Leukocyte transendothelial migration 0.548695652 0 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Long-term potentiation 0 -0.520750988 0 kegg kegg NA NA no no no no no up Viral carcinogenesis Longevity regulating pathway - multiple species 0 0 -0.417503218 kegg kegg NA NA no no no no no no Viral carcinogenesis Lysosome 0.413913043 0.636363636 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Maturity onset diabetes of the young 0 -0.595849802 0 kegg kegg NA NA no no no no up no Viral carcinogenesis Melanogenesis 0 -0.546442688 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Metabolism of xenobiotics by cytochrome P450 0 -0.481225296 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Mismatch repair -0.43826087 -0.713438735 -0.516859717 kegg kegg NA NA no no no no no no Viral carcinogenesis Mitophagy - animal 0 -0.499011858 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Morphine addiction 0 -0.469367589 0 kegg kegg NA NA no no no no up up Viral carcinogenesis mRNA surveillance pathway -0.508695652 -0.444664032 0 kegg kegg NA NA no no no no no no Viral carcinogenesis N-Glycan biosynthesis -0.467826087 -0.538537549 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Natural killer cell mediated cytotoxicity 0.891304348 0.947628458 0.878249678 kegg kegg NA NA no no no no no no Viral carcinogenesis Neuroactive ligand-receptor interaction 0 0.562252964 0 kegg kegg NA NA no no no up up up Viral carcinogenesis Neurotrophin signaling pathway 0 0.731225296 0.601801802 kegg kegg NA NA no no no no no no Viral carcinogenesis Neutrophil extracellular trap formation 0.493913043 0.593873518 0 kegg kegg NA NA no no no no no no Viral carcinogenesis NF-kappa B signaling pathway 0 0.54743083 0.406435006 kegg kegg NA NA no no no no no no Viral carcinogenesis Nicotinate and nicotinamide metabolism 0 0.535573123 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Nicotine addiction 0 0 0.424967825 kegg kegg NA NA no no no no up up Viral carcinogenesis Nitrogen metabolism 0.509565217 0 0 kegg kegg NA NA no no no no no no Viral carcinogenesis NOD-like receptor signaling pathway 0 0.720355731 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Non-alcoholic fatty liver disease 0 -0.416007905 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Nucleotide excision repair -0.546956522 -0.740118577 -0.693693694 kegg kegg NA NA no no no no no no Viral carcinogenesis One carbon pool by folate -0.575652174 -0.706521739 -0.451222651 kegg kegg NA NA no no no no no no Viral carcinogenesis Oocyte meiosis -0.545217391 -0.456521739 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Osteoclast differentiation 0 0.745059289 0.442728443 kegg kegg NA NA no no no no no no Viral carcinogenesis Other types of O-glycan biosynthesis -0.444347826 0 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Ovarian steroidogenesis 0 -0.420948617 0 kegg kegg NA NA no no no no up up Viral carcinogenesis Oxidative phosphorylation 0 -0.495059289 0 kegg kegg NA NA no no no no no no Viral carcinogenesis p53 signaling pathway -0.486086957 0 -0.486229086 kegg kegg NA NA no no no no no no Viral carcinogenesis Pancreatic secretion 0 -0.447628458 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Pantothenate and CoA biosynthesis 0 0.432806324 0 kegg kegg NA NA no no no no no dn Viral carcinogenesis "Parathyroid hormone synthesis, secretion and action" 0 -0.473320158 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Parkinson disease 0 -0.491106719 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Pathogenic Escherichia coli infection 0.547826087 0.748023715 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Pathways of neurodegeneration - multiple diseases 0 -0.520750988 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Pentose and glucuronate interconversions 0 -0.555335968 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Pentose phosphate pathway 0.600869565 0.647233202 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Pertussis 0 0.67687747 0 kegg kegg NA NA no no no no no dn Viral carcinogenesis Phagosome 0.806086957 0.852766798 0.668211068 kegg kegg NA NA no no no no no no Viral carcinogenesis Phenylalanine metabolism 0 -0.457509881 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Phosphatidylinositol signaling system -0.417391304 0 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Phospholipase D signaling pathway 0 0.456521739 0 kegg kegg NA NA no no no no up up Viral carcinogenesis Platinum drug resistance 0 0 -0.583526384 kegg kegg NA NA no no no no no no Viral carcinogenesis Porphyrin and chlorophyll metabolism 0 -0.709486166 0 kegg kegg NA NA no no no no no no Viral carcinogenesis PPAR signaling pathway 0.417391304 0.654150198 0.571943372 kegg kegg NA NA no no no no no no Viral carcinogenesis Primary bile acid biosynthesis -0.484347826 0 -0.468468468 kegg kegg NA NA no no no no no no Viral carcinogenesis Prion disease 0 -0.505928854 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Prolactin signaling pathway 0 0.677865613 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Propanoate metabolism 0 -0.52173913 -0.465894466 kegg kegg NA NA no no no no no no Viral carcinogenesis Protein digestion and absorption 0 0.540513834 0 yes kegg kegg NA NA no no no no up up Viral carcinogenesis Protein export -0.595652174 -0.416007905 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Protein processing in endoplasmic reticulum 0 -0.593873518 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Proximal tubule bicarbonate reclamation -0.451304348 -0.62055336 -0.461518662 kegg kegg NA NA no no no no no no Viral carcinogenesis Purine metabolism 0 -0.682806324 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Pyrimidine metabolism 0 -0.610671937 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Pyruvate metabolism 0 -0.627470356 -0.57966538 kegg kegg NA NA no no no no no no Viral carcinogenesis Rap1 signaling pathway 0.417391304 0 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Ras signaling pathway 0 -0.420948617 0 yes kegg kegg NA NA no no no no up up Viral carcinogenesis Relaxin signaling pathway 0 0.429841897 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Renin secretion 0 -0.626482213 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Renin-angiotensin system 0 0.694664032 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Retinol metabolism 0 -0.558300395 -0.556756757 kegg kegg NA NA no no no no no no Viral carcinogenesis Retrograde endocannabinoid signaling 0 -0.505928854 0 kegg kegg NA NA no no no no no up Viral carcinogenesis Ribosome 0 -0.434782609 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Ribosome biogenesis in eukaryotes -0.557391304 -0.59486166 0 kegg kegg NA NA no no no no no no Viral carcinogenesis RIG-I-like receptor signaling pathway 0 0.558300395 0.466924067 kegg kegg NA NA no no no no no no Viral carcinogenesis RNA degradation -0.513913043 -0.4743083 0 kegg kegg NA NA no no no no no no Viral carcinogenesis RNA polymerase -0.554782609 -0.660079051 -0.44015444 kegg kegg NA NA no no no no no no Viral carcinogenesis Salmonella infection 0 0.601778656 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Sarcina 0 0.422326513 0 kegg Genus NA 0.0703 no no no no no no Viral carcinogenesis Selenocompound metabolism -0.535652174 -0.420948617 -0.538996139 kegg kegg NA NA no no no no no no Viral carcinogenesis Sphingolipid signaling pathway 0 0.789525692 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Staphylococcus aureus infection 0 0.638339921 0 kegg kegg NA NA no no no up no no Viral carcinogenesis Starch and sucrose metabolism 0 0.429841897 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Steroid biosynthesis -0.788695652 -0.613636364 -0.510939511 kegg kegg NA NA no no no no no no Viral carcinogenesis Steroid hormone biosynthesis 0 -0.630434783 -0.415958816 kegg kegg NA NA no no no no no no Viral carcinogenesis Sulfur metabolism 0 -0.43972332 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Synaptic vesicle cycle 0 0.441699605 0 kegg kegg NA NA no no no no up up Viral carcinogenesis Synthesis and degradation of ketone bodies -0.488695652 -0.732213439 -0.562934363 kegg kegg NA NA no no no no no no Viral carcinogenesis Taste transduction -0.563478261 -0.698616601 0 kegg kegg NA NA no no no no no up Viral carcinogenesis Taurine and hypotaurine metabolism -0.406956522 0 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Terpenoid backbone biosynthesis -0.788695652 -0.423913043 0 kegg kegg NA NA no no no no no no Viral carcinogenesis TGF-beta signaling pathway -0.460869565 0 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Th1 and Th2 cell differentiation 0 0.605731225 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Th17 cell differentiation 0 0.613636364 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Thermogenesis 0 -0.528656126 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Thiamine metabolism 0 -0.668972332 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Thyroid hormone synthesis 0 -0.450592885 0 kegg kegg NA NA no no no no no no Viral carcinogenesis TNF signaling pathway 0 0.673913043 0.652509653 kegg kegg NA NA no no no no no no Viral carcinogenesis Toll-like receptor signaling pathway 0.410434783 0.735177866 0.721492921 yes kegg kegg NA NA no no no no no no Viral carcinogenesis Toxoplasmosis 0 0.552371542 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Transcriptional misregulation in cancer 0 0.414031621 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Tryptophan metabolism 0 0 -0.445302445 kegg kegg NA NA no no no no up no Viral carcinogenesis Tuberculosis 0 0.650197628 0 kegg kegg NA NA no no no no no dn Viral carcinogenesis Type I diabetes mellitus 0.803478261 0.918972332 0.858172458 kegg kegg NA NA no no no no no no Viral carcinogenesis Tyrosine metabolism 0 -0.683794466 -0.604890605 kegg kegg NA NA no no no no no no Viral carcinogenesis Ubiquinone and other terpenoid-quinone biosynthesis -0.46173913 -0.626482213 -0.593822394 kegg kegg NA NA no no no no no no Viral carcinogenesis Ubiquitin mediated proteolysis 0 -0.596837945 0 kegg kegg NA NA no no no no no no Viral carcinogenesis "Valine, leucine and isoleucine degradation" 0 -0.604743083 -0.572715573 kegg kegg NA NA no no no no no no Viral carcinogenesis Vascular smooth muscle contraction 0 -0.529644269 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Vasopressin-regulated water reabsorption 0 -0.545454545 0 kegg kegg NA NA no no no no no no Viral carcinogenesis VEGF signaling pathway 0 0.588932806 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Viral protein interaction with cytokine and cytokine receptor 0.422608696 0 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Vitamin digestion and absorption -0.529565217 0 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Wnt signaling pathway 0 -0.497035573 0 kegg kegg NA NA no no no no no no Viral carcinogenesis Yersinia infection 0.44173913 0.683794466 0 kegg kegg NA NA no no no no no no Viral myocarditis 2-Oxocarboxylic acid metabolism 0.480869565 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Adherens junction 0.492173913 0 0.473359073 kegg kegg NA NA no no no no no no Viral myocarditis Aldosterone synthesis and secretion 0 -0.524703557 0 kegg kegg NA NA no no no no up up Viral myocarditis Allograft rejection 0.972173913 0.967391304 0.958815959 kegg kegg NA NA no no no no no no Viral myocarditis Alzheimer disease -0.476521739 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Amphetamine addiction 0 -0.571146245 0 kegg kegg NA NA no no no no no no Viral myocarditis AMPK signaling pathway 0 -0.612648221 0 kegg kegg NA NA no no no no no no Viral myocarditis Amyotrophic lateral sclerosis -0.409565217 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Antifolate resistance 0 0 -0.454826255 kegg kegg NA NA no no no no no no Viral myocarditis Antigen processing and presentation 0 0.508893281 0.608751609 kegg kegg NA NA no no no no no no Viral myocarditis Apelin signaling pathway -0.540869565 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Apoptosis 0.475652174 0.614624506 0.450707851 kegg kegg NA NA no no no no no no Viral myocarditis Apoptosis - multiple species 0 0 -0.572715573 kegg kegg NA NA no no no no no no Viral myocarditis Arrhythmogenic right ventricular cardiomyopathy 0.56173913 0 0.494465894 kegg kegg NA NA no no no no up up Viral myocarditis Asthma 0.412173913 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Autoimmune thyroid disease 0.972173913 0.967391304 0.958815959 kegg kegg NA NA no no no no no no Viral myocarditis Autophagy - animal -0.45826087 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Autophagy - other -0.68173913 0 -0.424195624 kegg kegg NA NA no no no no no no Viral myocarditis Bacterial invasion of epithelial cells 0.534782609 0.486166008 0.479021879 kegg kegg NA NA no no no no no no Viral myocarditis Basal transcription factors -0.696521739 -0.599802372 -0.645817246 kegg kegg NA NA no no no no no no Viral myocarditis Base excision repair -0.412173913 -0.528656126 -0.508622909 kegg kegg NA NA no no no no no no Viral myocarditis Biosynthesis of amino acids 0.56 0.502964427 0 kegg kegg NA NA no no no no no no Viral myocarditis Biosynthesis of cofactors 0 -0.772727273 0 kegg kegg NA NA no no no no no no Viral myocarditis Butyricicoccus 0 0 0.484557649 butyrate-producing kegg Genus NA 0.852 no no no no no no Viral myocarditis cAMP signaling pathway -0.417391304 0 0 yes kegg kegg NA NA no no no no up up Viral myocarditis Carbon metabolism 0.484347826 0.494071146 0 kegg kegg NA NA no no no no no no Viral myocarditis Cell adhesion molecules 0.929565217 0.912055336 0.947490347 kegg kegg NA NA no no no no no no Viral myocarditis Cell cycle -0.668695652 -0.559288538 0 kegg kegg NA NA no no no no no no Viral myocarditis Cellular senescence 0.782608696 0.875494071 0.812097812 kegg kegg NA NA no no no no no no Viral myocarditis Central carbon metabolism in cancer 0 0 -0.492921493 kegg kegg NA NA no no no no no no Viral myocarditis cGMP-PKG signaling pathway 0 0.432806324 0 kegg kegg NA NA no no no no no no Viral myocarditis Chemical carcinogenesis - receptor activation -0.469565217 -0.603754941 0 kegg kegg NA NA no no no no no no Viral myocarditis Chemokine signaling pathway 0 0 0.544144144 kegg kegg NA NA no no no no no no Viral myocarditis Cholesterol metabolism 0 0.677865613 0 yes kegg kegg NA NA no no no no no up Viral myocarditis Cholinergic synapse -0.413043478 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Circadian rhythm -0.54173913 -0.510869565 0 kegg kegg NA NA no no no no no no Viral myocarditis Cocaine addiction 0 -0.475296443 0 kegg kegg NA NA no no no no no no Viral myocarditis Complement and coagulation cascades 0.491304348 0.494071146 0.450965251 kegg kegg NA NA no no no no no no Viral myocarditis Cortisol synthesis and secretion 0 -0.604743083 0 kegg kegg NA NA no no no no no up Viral myocarditis Cushing syndrome 0 -0.669960474 0 kegg kegg NA NA no no no no no up Viral myocarditis Dilated cardiomyopathy 0.502608696 0 0 kegg kegg NA NA no no no no up up Viral myocarditis DNA replication 0 0 -0.431145431 kegg kegg NA NA no no no no no no Viral myocarditis Dopaminergic synapse -0.433043478 0 0 kegg kegg NA NA no no no no up no Viral myocarditis Endocrine resistance 0 -0.544466403 0 kegg kegg NA NA no no no no no no Viral myocarditis Endocytosis 0.79826087 0.896245059 0.859459459 kegg kegg NA NA no no no no no no Viral myocarditis Epithelial cell signaling in Helicobacter pylori infection 0 0.464426877 0.522007722 kegg kegg NA NA no no no no no no Viral myocarditis Epstein-Barr virus infection 0 0.520750988 0.642985843 kegg kegg NA NA no no no no no no Viral myocarditis Estrogen signaling pathway -0.436521739 -0.443675889 0 kegg kegg NA NA no no no no no no Viral myocarditis Ether lipid metabolism -0.411304348 -0.625494071 0 kegg kegg NA NA no no no no no no Viral myocarditis Eubacterium 0 0 -0.412239157 kegg Genus NA 0.0692 no no no no no no Viral myocarditis Fanconi anemia pathway -0.46 -0.56916996 -0.543886744 kegg kegg NA NA no no no no no no Viral myocarditis Fc epsilon RI signaling pathway 0 0.464426877 0 kegg kegg NA NA no no no no no no Viral myocarditis Fc gamma R-mediated phagocytosis 0 0.468379447 0 kegg kegg NA NA no no no no no no Viral myocarditis Focal adhesion 0.513913043 0 0.423166023 kegg kegg NA NA no no no no up up Viral myocarditis Folate biosynthesis -0.412173913 0 0 kegg kegg NA NA no no no no no no Viral myocarditis FoxO signaling pathway 0 0 -0.518918919 kegg kegg NA NA no no no no no no Viral myocarditis Glucagon signaling pathway 0 -0.530632411 0 kegg kegg NA NA no no no no no no Viral myocarditis Glutathione metabolism 0 -0.415019763 0 kegg kegg NA NA no no no no no no Viral myocarditis Glycerophospholipid metabolism -0.470434783 -0.562252964 -0.403603604 kegg kegg NA NA no no no no no up Viral myocarditis "Glycine, serine and threonine metabolism" 0 -0.704545455 0 kegg kegg NA NA no no no no up no Viral myocarditis Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.499130435 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Glycosaminoglycan degradation 0 0.583003953 0 kegg kegg NA NA no no no no no up Viral myocarditis Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0 -0.732213439 0 kegg kegg NA NA no no no no no no Viral myocarditis GnRH signaling pathway 0 -0.52173913 0 kegg kegg NA NA no no no no no no Viral myocarditis Graft-versus-host disease 0.969565217 0.967391304 0.95958816 kegg kegg NA NA no no no no no no Viral myocarditis Hedgehog signaling pathway 0 -0.437747036 0 kegg kegg NA NA no no no no no no Viral myocarditis Hepatocellular carcinoma 0.549565217 0 0.407722008 kegg kegg NA NA no no no no no no Viral myocarditis Herpes simplex virus 1 infection 0 0.482213439 0.603603604 kegg kegg NA NA no no no no no no Viral myocarditis Hippo signaling pathway 0 0 0.425997426 kegg kegg NA NA no no no no no no Viral myocarditis Homologous recombination -0.415652174 -0.556324111 -0.612097812 kegg kegg NA NA no no no no no no Viral myocarditis Human cytomegalovirus infection 0 0.498023715 0.594079794 kegg kegg NA NA no no no no no dn Viral myocarditis Human immunodeficiency virus 1 infection 0 0.500988142 0.564221364 kegg kegg NA NA no no no no no no Viral myocarditis Human papillomavirus infection 0.816521739 0.838932806 0.79047619 kegg kegg NA NA no no no no no no Viral myocarditis Human T-cell leukemia virus 1 infection 0 0.489130435 0.634234234 kegg kegg NA NA no no no no no no Viral myocarditis Huntington disease -0.453043478 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Hypertrophic cardiomyopathy 0.608695652 0 0.488545689 kegg kegg NA NA no no no no up up Viral myocarditis IL-17 signaling pathway 0 0.492094862 0 kegg kegg NA NA no no no no no no Viral myocarditis Inflammatory bowel disease 0 0.424901186 0 kegg kegg NA NA no no no no no no Viral myocarditis Influenza A 0.688695652 0.838932806 0.677734878 kegg kegg NA NA no no no no no no Viral myocarditis Insulin resistance -0.510434783 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Insulin secretion 0 -0.530632411 0 yes kegg kegg NA NA no no no no up up Viral myocarditis Insulin signaling pathway -0.526956522 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Intestinal immune network for IgA production 0 0.469367589 0 kegg kegg NA NA no no no no no no Viral myocarditis Leukocyte transendothelial migration 0.611304348 0.583003953 0.594851995 kegg kegg NA NA no no no no no no Viral myocarditis Long-term potentiation -0.546956522 0 0 kegg kegg NA NA no no no no no up Viral myocarditis Longevity regulating pathway 0 -0.473320158 0 kegg kegg NA NA no no no no no no Viral myocarditis Lysosome 0 0.67687747 0 kegg kegg NA NA no no no no no no Viral myocarditis MAPK signaling pathway -0.605217391 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Maturity onset diabetes of the young 0 -0.46541502 0 kegg kegg NA NA no no no no up no Viral myocarditis Measles -0.534782609 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Mismatch repair 0 -0.504940711 0 kegg kegg NA NA no no no no no no Viral myocarditis mRNA surveillance pathway -0.599130435 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Natural killer cell mediated cytotoxicity 0.807826087 0.89229249 0.843500644 kegg kegg NA NA no no no no no no Viral myocarditis Neuroactive ligand-receptor interaction 0 0.557312253 0 kegg kegg NA NA no no no up up up Viral myocarditis Neutrophil extracellular trap formation 0.452173913 0.572134387 0.472844273 kegg kegg NA NA no no no no no no Viral myocarditis Non-alcoholic fatty liver disease -0.470434783 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Nucleotide excision repair 0 -0.54743083 -0.552123552 kegg kegg NA NA no no no no no no Viral myocarditis One carbon pool by folate 0 -0.459486166 0 kegg kegg NA NA no no no no no no Viral myocarditis Oocyte meiosis -0.595652174 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Osteoclast differentiation 0 0.458498024 0 kegg kegg NA NA no no no no no no Viral myocarditis Other types of O-glycan biosynthesis -0.564347826 -0.56916996 -0.500643501 kegg kegg NA NA no no no no no no Viral myocarditis Ovarian steroidogenesis 0 -0.422924901 0 kegg kegg NA NA no no no no up up Viral myocarditis Oxidative phosphorylation -0.424347826 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Oxytocin signaling pathway 0.444347826 0 0 kegg kegg NA NA no no no no no no Viral myocarditis p53 signaling pathway -0.600869565 -0.538537549 -0.642213642 kegg kegg NA NA no no no no no no Viral myocarditis Pathogenic Escherichia coli infection 0.471304348 0.725296443 0.64015444 kegg kegg NA NA no no no no no no Viral myocarditis Pathways in cancer -0.571304348 0 -0.496782497 kegg kegg NA NA no no no no no no Viral myocarditis Pentose phosphate pathway 0.512173913 0.613636364 0 kegg kegg NA NA no no no no no no Viral myocarditis Pertussis 0 0.557312253 0 kegg kegg NA NA no no no no no dn Viral myocarditis Phagosome 0.89826087 0.872529644 0.881853282 kegg kegg NA NA no no no no no no Viral myocarditis Phosphatidylinositol signaling system -0.419130435 -0.420948617 -0.417503218 kegg kegg NA NA no no no no no no Viral myocarditis PI3K-Akt signaling pathway -0.572173913 0 0 yes kegg kegg NA NA no no no no up up Viral myocarditis Platelet activation 0.422608696 0 0.469498069 kegg kegg NA NA no no no no no no Viral myocarditis Platinum drug resistance -0.431304348 0 -0.613899614 kegg kegg NA NA no no no no no no Viral myocarditis Porphyrin and chlorophyll metabolism 0 -0.65513834 0 kegg kegg NA NA no no no no no no Viral myocarditis Primary immunodeficiency 0 -0.549407115 0 kegg kegg NA NA no no no no no no Viral myocarditis Prion disease -0.426086957 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Progesterone-mediated oocyte maturation -0.495652174 0 -0.447619048 kegg kegg NA NA no no no no no no Viral myocarditis Protein export -0.625217391 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Proximal tubule bicarbonate reclamation 0 0 -0.423166023 kegg kegg NA NA no no no no no no Viral myocarditis Purine metabolism 0 -0.661067194 0 kegg kegg NA NA no no no no no no Viral myocarditis Rap1 signaling pathway 0.513913043 0.488142292 0.523294723 kegg kegg NA NA no no no no no no Viral myocarditis Renin-angiotensin system 0 0.576086957 0 kegg kegg NA NA no no no no no no Viral myocarditis Retinol metabolism 0 -0.416007905 0 kegg kegg NA NA no no no no no no Viral myocarditis Retrograde endocannabinoid signaling -0.506956522 0 0 kegg kegg NA NA no no no no no up Viral myocarditis Rheumatoid arthritis 0.637391304 0.675889328 0.501415701 kegg kegg NA NA no no no no no no Viral myocarditis Ribosome biogenesis in eukaryotes -0.515652174 -0.504940711 -0.439382239 kegg kegg NA NA no no no no no no Viral myocarditis RNA degradation -0.513913043 0 0 kegg kegg NA NA no no no no no no Viral myocarditis RNA polymerase -0.562608696 -0.516798419 -0.404375804 kegg kegg NA NA no no no no no no Viral myocarditis Salmonella infection 0 0.666996047 0.502960103 kegg kegg NA NA no no no no no no Viral myocarditis Selenocompound metabolism -0.59826087 -0.60770751 -0.548262548 kegg kegg NA NA no no no no no no Viral myocarditis Sphingolipid metabolism 0 0.468379447 0 kegg kegg NA NA no no no no no no Viral myocarditis Sphingolipid signaling pathway 0 0.662055336 0 kegg kegg NA NA no no no no no no Viral myocarditis Spinocerebellar ataxia -0.464347826 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Spliceosome -0.536521739 0 -0.451994852 kegg kegg NA NA no no no no no no Viral myocarditis Staphylococcus aureus infection 0.572173913 0.68972332 0.438095238 kegg kegg NA NA no no no up no no Viral myocarditis Steroid biosynthesis -0.602608696 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Synthesis and degradation of ketone bodies 0 -0.558300395 -0.434749035 kegg kegg NA NA no no no no no no Viral myocarditis Systemic lupus erythematosus 0 0.639328063 0 kegg kegg NA NA no no no no no no Viral myocarditis Taste transduction -0.629565217 -0.574110672 0 kegg kegg NA NA no no no no no up Viral myocarditis Taurine and hypotaurine metabolism -0.407826087 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Terpenoid backbone biosynthesis -0.750434783 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Th1 and Th2 cell differentiation 0 0.516798419 0 kegg kegg NA NA no no no no no no Viral myocarditis Th17 cell differentiation 0 0.463438735 0 kegg kegg NA NA no no no no no no Viral myocarditis Thiamine metabolism 0 -0.5256917 0 kegg kegg NA NA no no no no no no Viral myocarditis Thyroid hormone signaling pathway 0.472173913 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Thyroid hormone synthesis 0 -0.436758893 0 kegg kegg NA NA no no no no no no Viral myocarditis Tight junction 0.413913043 0 0.41029601 kegg kegg NA NA no no no no no no Viral myocarditis Toll-like receptor signaling pathway 0 0 0.42007722 yes kegg kegg NA NA no no no no no no Viral myocarditis Toxoplasmosis 0 0.473320158 0 kegg kegg NA NA no no no no no no Viral myocarditis Tuberculosis 0.483478261 0.636363636 0 kegg kegg NA NA no no no no no dn Viral myocarditis Type I diabetes mellitus 0.972173913 0.966403162 0.957786358 kegg kegg NA NA no no no no no no Viral myocarditis Ubiquinone and other terpenoid-quinone biosynthesis 0 -0.414031621 -0.424710425 kegg kegg NA NA no no no no no no Viral myocarditis Ubiquitin mediated proteolysis 0 -0.461462451 0 kegg kegg NA NA no no no no no no Viral myocarditis Various types of N-glycan biosynthesis -0.419130435 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Vibrio cholerae infection 0 0 0.485714286 kegg kegg NA NA no no no no no no Viral myocarditis Viral carcinogenesis 0.783478261 0.836956522 0.786615187 kegg kegg NA NA no no no no no no Viral myocarditis Vitamin digestion and absorption -0.487826087 0 0 kegg kegg NA NA no no no no no no Viral myocarditis Yersinia infection 0 0.68972332 0.55958816 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor 2-Oxocarboxylic acid metabolism 0 -0.515810277 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Aminoacyl-tRNA biosynthesis 0 -0.637351779 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Antifolate resistance -0.453913043 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Arachidonic acid metabolism 0 0.643280632 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Arginine and proline metabolism 0 0.422924901 0 kegg kegg NA NA no no no no up no Viral protein interaction with cytokine and cytokine receptor Arginine biosynthesis 0 0.428853755 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Basal transcription factors 0 -0.537549407 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Base excision repair 0 -0.499011858 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Biosynthesis of amino acids 0 0.453557312 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Butyricimonas 0.460855682 0 0 butyrate-producing kegg Genus NA 0.17 no no no no no no Viral protein interaction with cytokine and cytokine receptor Calcium signaling pathway 0.41826087 0 0 kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor cGMP-PKG signaling pathway 0 0.570158103 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Cytokine-cytokine receptor interaction 0.806086957 0.763833992 0.761132561 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor DNA replication 0 -0.459486166 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor ErbB signaling pathway 0 0 -0.53976834 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Ether lipid metabolism 0 -0.416996047 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Fanconi anemia pathway -0.414782609 -0.649209486 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Folate biosynthesis -0.443478261 -0.52173913 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Galactose metabolism -0.424347826 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Glutathione metabolism 0 0 0.412612613 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Glycerolipid metabolism 0 0 -0.473873874 kegg kegg NA NA no no no no no up Viral protein interaction with cytokine and cytokine receptor Glycerophospholipid metabolism -0.56 0 -0.576833977 kegg kegg NA NA no no no no no up Viral protein interaction with cytokine and cytokine receptor Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 -0.457509881 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Glycosphingolipid biosynthesis - ganglio series 0 -0.540513834 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Glyoxylate and dicarboxylate metabolism 0 0.41798419 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Histidine metabolism -0.597391304 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Homologous recombination 0 -0.562252964 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Inositol phosphate metabolism -0.455652174 -0.522727273 -0.564478764 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Lysine degradation 0 -0.778656126 -0.583011583 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Mannose type O-glycan biosynthesis 0 -0.701581028 -0.444530245 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor MAPK signaling pathway 0 0 -0.499099099 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor mRNA surveillance pathway 0 -0.670948617 -0.450707851 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Mucin type O-glycan biosynthesis 0 -0.41798419 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor N-Glycan biosynthesis 0 -0.476284585 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Nicotinate and nicotinamide metabolism 0 0.416007905 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Nitrogen metabolism 0 0.48715415 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor One carbon pool by folate -0.429565217 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Other glycan degradation 0 -0.553359684 -0.469498069 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Other types of O-glycan biosynthesis 0 -0.621541502 -0.575289575 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Pantothenate and CoA biosynthesis 0 0.43972332 0 kegg kegg NA NA no no no no no dn Viral protein interaction with cytokine and cytokine receptor Pentose and glucuronate interconversions 0 -0.443675889 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Pentose phosphate pathway 0 0.600790514 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Platinum drug resistance 0 -0.481225296 -0.428056628 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Pyrimidine metabolism -0.454782609 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Rap1 signaling pathway 0 0 0.564993565 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Ras signaling pathway 0.539130435 0 0 yes kegg kegg NA NA no no no no up up Viral protein interaction with cytokine and cytokine receptor Ribosome biogenesis in eukaryotes 0 -0.633399209 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor RNA degradation 0 -0.565217391 -0.451480051 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor RNA polymerase 0 -0.59486166 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Selenocompound metabolism -0.52173913 -0.586956522 -0.534105534 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Spliceosome 0 -0.669960474 -0.494465894 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Synthesis and degradation of ketone bodies -0.406086957 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Taurine and hypotaurine metabolism -0.43826087 0 -0.527155727 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Terpenoid backbone biosynthesis 0 -0.429841897 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Thiamine metabolism -0.484347826 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Ubiquinone and other terpenoid-quinone biosynthesis -0.58173913 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor "Valine, leucine and isoleucine degradation" -0.454782609 0 0 kegg kegg NA NA no no no no no no Viral protein interaction with cytokine and cytokine receptor Various types of N-glycan biosynthesis 0 -0.541501976 0 kegg kegg NA NA no no no no no no Visfatin 14:0/18:2-PC+blood 0 -0.526960784 0 DM-assocaited hormones serum_phospholipids 0.0229 0.102 dn no up no up no Visfatin 15-HETE+blood 0 0 0.427849393 DM-assocaited hormones serum_ARA 0.0229 0.819 dn no up no no no Visfatin 16:0/16:1-PC+blood 0 -0.772058824 0 DM-assocaited hormones serum_phospholipids 0.0229 0.00283 dn no up up up no Visfatin 16:0/18:2-PI+blood 0 -0.683823529 0 DM-assocaited hormones serum_phospholipids 0.0229 0.269 dn no up no no no Visfatin 16:0/20:4-PI+blood 0 -0.490196078 0 DM-assocaited hormones serum_phospholipids 0.0229 0.558 dn no up no no no Visfatin 16:0/22:6-PC+blood 0 0.482843137 0 DM-assocaited hormones serum_phospholipids 0.0229 4.53E-05 dn no up no up up Visfatin 16:1/16:0-PC+blood 0 0.482843137 0 DM-assocaited hormones serum_phospholipids 0.0229 0.0215 dn no up no up up Visfatin 18:0-LPC+blood 0 0 0.423478261 DM-assocaited hormones serum_phospholipids 0.0229 0.554 dn no up no no no Visfatin 18:0/18:1-PC+blood 0 -0.514705882 0 DM-assocaited hormones serum_phospholipids 0.0229 0.393 dn no up no no no Visfatin 18:0/18:1-PE+blood 0 -0.659313725 0 DM-assocaited hormones serum_phospholipids 0.0229 0.00716 dn no up up up no Visfatin 18:0/20:3-PC+blood 0 -0.583333333 0 DM-assocaited hormones serum_phospholipids 0.0229 0.0682 dn no up no up no Visfatin 18:0/20:4-PI+blood 0.521155831 0 0 DM-assocaited hormones serum_phospholipids 0.0229 0.167 dn no up no no no Visfatin 18:0/20:5-PC+blood 0 0.588235294 0 DM-assocaited hormones serum_phospholipids 0.0229 0.17 dn no up no no no Visfatin 18:1-LPC+blood 0 0.490196078 0 DM-assocaited hormones serum_phospholipids 0.0229 0.179 dn no up no no no Visfatin 18:1/18:1-PE+blood 0 -0.539215686 0 DM-assocaited hormones serum_phospholipids 0.0229 1.03E-05 dn no up up up no Visfatin 18:1/18:2-PG+blood 0 0 0.445217391 DM-assocaited hormones serum_phospholipids 0.0229 5.58E-07 dn no up no up up Visfatin 18:1/20:4-PC+blood 0 0.522058824 0 DM-assocaited hormones serum_phospholipids 0.0229 0.582 dn no up no no no Visfatin 18:3n3+blood 0 0.524509804 0 DM-assocaited hormones serum_fattyacid 0.0229 0.291 dn no up no no no Visfatin 20:2/18:0-PC+blood 0 -0.566176471 0 DM-assocaited hormones serum_phospholipids 0.0229 0.0427 dn no up no up no Visfatin 20:3n6+blood 0 -0.519607843 0 DM-assocaited hormones serum_fattyacid 0.0229 0.0884 dn no up up no no Visfatin 20:5/18:0-PC+blood 0 0.529411765 0 DM-assocaited hormones serum_phospholipids 0.0229 3.97E-06 dn no up no up up Visfatin 4-hydroxybenzoic acid+stool 0 0 -0.455844156 DM-assocaited hormones stool_cometabolism 0.0229 0.0536 dn no up no dn no Visfatin 8-HETE+blood 0 0.742647059 0 DM-assocaited hormones serum_ARA 0.0229 0.741 dn no up no no no Visfatin AA+blood 0 0.56372549 0 DM-assocaited hormones serum_ARA 0.0229 0.212 dn no up no no no Visfatin ACA+stool -0.52935619 0 0 DM-assocaited hormones stool_bileacids 0.0229 0.417 dn no up no no no Visfatin Adrenergic signaling in cardiomyocytes -0.480519481 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no up Visfatin Aldosterone synthesis and secretion -0.470355731 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no up up Visfatin Allograft rejection 0 0 -0.503008021 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Amphetamine addiction -0.463579898 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Arginine and proline metabolism 0.465838509 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no up no Visfatin Autoimmune thyroid disease 0 0 -0.503008021 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Axon guidance 0 -0.414031621 0 DM-assocaited hormones kegg 0.0229 NA dn no up no up up Visfatin Betaine+blood 0 0.546568627 0 DM-assocaited hormones serum_choline 0.0229 0.857 dn no up no no no Visfatin Blautia 0 0.432173913 0 acetate-producing DM-assocaited hormones Genus 0.0229 1.36E-05 dn no up up dn dn Visfatin C-peptide -0.59486166 0 -0.571428571 DM-assocaited hormones DM-assocaited hormones 0.0229 0.228 dn no up no no no Visfatin Cell adhesion molecules 0 0 -0.462566845 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Cellular senescence 0 0 -0.495320856 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Chemical carcinogenesis - receptor activation -0.454545455 0 0.527740642 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Circadian entrainment -0.427442123 0 0.420120321 DM-assocaited hormones kegg 0.0229 NA dn no up no up up Visfatin Coronavirus disease - COVID-19 0 -0.414031621 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Cushing syndrome -0.444381705 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no up Visfatin d18:1-18:0-SM+blood 0 0.544117647 0 DM-assocaited hormones serum_phospholipids 0.0229 0.97 dn no up no no no Visfatin d18:1-20:1-SM+blood 0 0.553921569 0 DM-assocaited hormones serum_phospholipids 0.0229 0.0992 dn no up no no no Visfatin d18:1-24:1-SM+blood 0.486068111 0 0 DM-assocaited hormones serum_phospholipids 0.0229 0.0123 dn no up no dn dn Visfatin DHA+blood 0 0.526960784 0 DM-assocaited hormones serum_ARA 0.0229 0.872 dn no up no no no Visfatin Dopaminergic synapse -0.489553924 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no up no Visfatin DPA+blood 0 0.490196078 0 DM-assocaited hormones serum_ARA 0.0229 0.519 dn no up no no no Visfatin EGFR tyrosine kinase inhibitor resistance 0 -0.416007905 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Endocrine and other factor-regulated calcium reabsorption 0 0 0.466911765 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Endocrine resistance 0 0 0.461564171 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Endocytosis 0 0 -0.479612299 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin EPA+blood 0 0.531862745 0 DM-assocaited hormones serum_ARA 0.0229 0.212 dn no up no no no Visfatin Ethanolamine+blood 0 0.487745098 0 DM-assocaited hormones serum_aminoacids 0.0229 0.122 dn no up up no no Visfatin Gap junction -0.532467532 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin GCDCA+stool -0.629411765 0 0 yes DM-assocaited hormones stool_bileacids 0.0229 0.0471 dn no up no dn no Visfatin GLCA+blood 0 0 0.409776153 DM-assocaited hormones serum_bileacids 0.0229 0.319 dn no up no no no Visfatin GLP-1 0 0 -0.408963585 DM-assocaited hormones DM-assocaited hormones 0.0229 0.256 dn no up no no no Visfatin Glucagon 0 0 -0.421848739 DM-assocaited hormones DM-assocaited hormones 0.0229 0.0283 dn no up no no up Visfatin Glycine+blood 0 0.529411765 0 DM-assocaited hormones serum_aminoacids 0.0229 0.00408 dn no up dn no up Visfatin Graft-versus-host disease 0 0 -0.503342246 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin GUDCA+blood 0 -0.514705882 0 DM-assocaited hormones serum_bileacids 0.0229 0.0766 dn no up no no dn Visfatin HCA+blood 0 -0.492291066 0 DM-assocaited hormones serum_bileacids 0.0229 0.544 dn no up no no no Visfatin HIF-1 signaling pathway 0 -0.433794466 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin IL-8 0 0 0.413245758 DM-assocaited hormones serum_cytokines 0.0229 0.579 dn no up no no no Visfatin Indole-3-Acetic acid+urine 0 0 0.517786561 DM-assocaited hormones urine_cometabolism 0.0229 0.657 dn no up no no no Visfatin Inflammatory mediator regulation of TRP channels -0.482778091 0 0.409759358 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Insulin -0.641304348 0 0 yes DM-assocaited hormones DM-assocaited hormones 0.0229 0.00058 dn no up up up no Visfatin Intestinal immune network for IgA production 0 -0.524703557 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Kaposi sarcoma-associated herpesvirus infection -0.429700734 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no dn Visfatin L-Asparagine+blood 0 0.568627451 0 DM-assocaited hormones serum_aminoacids 0.0229 0.784 dn no up no no no Visfatin L-Glutamine+blood 0 0.490196078 0 DM-assocaited hormones serum_aminoacids 0.0229 0.639 dn no up no no no Visfatin L-Phenylalanine+urine 0 -0.489473684 0 DM-assocaited hormones urine_cometabolism 0.0229 0.0908 dn no up no up no Visfatin L-Tryptophan+urine 0 -0.524561404 0 DM-assocaited hormones urine_cometabolism 0.0229 0.226 dn no up no no no Visfatin Leptin 0 -0.408695652 -0.411484594 DM-assocaited hormones DM-assocaited hormones 0.0229 0.706 dn no up no no no Visfatin Morphine addiction -0.45567476 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no up up Visfatin mTOR signaling pathway 0 -0.429841897 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin MUFA%+blood 0 0.593137255 0 DM-assocaited hormones serum_fattyacid 0.0229 0.00142 dn no up up no dn Visfatin Natural killer cell mediated cytotoxicity 0 0 -0.49565508 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin PAI-1 -0.539525692 0 0 yes DM-assocaited hormones DM-assocaited hormones 0.0229 5.10E-05 dn no up up up up Visfatin Pancreatic secretion -0.495200452 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin "Parathyroid hormone synthesis, secretion and action" -0.435347261 0 0.454545455 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Peroxisome 0.612648221 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Phenylacetyl L-GlutaMine+urine 0 0.584210526 0 DM-assocaited hormones urine_cometabolism 0.0229 0.0909 dn no up up no no Visfatin PUFA%+blood 0 0.551470588 0 DM-assocaited hormones serum_fattyacid 0.0229 0.0013 dn no up dn no up Visfatin Regulation of lipolysis in adipocytes 0 0 0.451871658 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Renin secretion -0.464709204 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Resistin 0.562252964 0.448695652 0.590196078 DM-assocaited hormones DM-assocaited hormones 0.0229 0.156 dn no up no no no Visfatin Ruminococcus -0.494071146 0 0 acetate-producing DM-assocaited hormones Genus 0.0229 0.335 dn no up no no no Visfatin Serine+blood 0 0.610294118 0 DM-assocaited hormones serum_aminoacids 0.0229 0.942 dn no up no no no Visfatin Systemic lupus erythematosus 0.590062112 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Taurine+blood 0 0.644607843 0 DM-assocaited hormones serum_aminoacids 0.0229 0.857 dn no up no no no Visfatin Thyroid hormone synthesis -0.454545455 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin TMAO+blood 0 0.742647059 0 DM-assocaited hormones serum_choline 0.0229 0.00706 dn no up up up no Visfatin Tuberculosis 0.465838509 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no dn Visfatin TXB2+blood 0 0.668914578 0 yes DM-assocaited hormones serum_ARA 0.0229 0.0644 dn no up dn no no Visfatin Type I diabetes mellitus 0 0 -0.509692513 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin UFA%+blood 0 0.507352941 0 DM-assocaited hormones serum_fattyacid 0.0229 0.0236 dn no up no dn no Visfatin Vascular smooth muscle contraction 0 0 0.409759358 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Viral myocarditis 0 0 -0.421791444 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Visfatin Viral protein interaction with cytokine and cytokine receptor -0.459062676 0 0 DM-assocaited hormones kegg 0.0229 NA dn no up no no no Vitamin digestion and absorption 2-Oxocarboxylic acid metabolism -0.613043478 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Adrenergic signaling in cardiomyocytes 0.429565217 0 0 kegg kegg NA NA no no no no no up Vitamin digestion and absorption Aldosterone synthesis and secretion 0.450434783 0 0 kegg kegg NA NA no no no no up up Vitamin digestion and absorption alpha-Linolenic acid metabolism -0.600869565 0.471343874 0.414671815 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Amino sugar and nucleotide sugar metabolism -0.624347826 0.561264822 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Aminoacyl-tRNA biosynthesis -0.473043478 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption AMPK signaling pathway 0 0 -0.577348777 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Antifolate resistance 0 0 0.593822394 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Antigen processing and presentation -0.526956522 0 -0.418790219 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Apoptosis -0.435652174 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Ascorbate and aldarate metabolism 0 0 0.51994852 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Axon guidance 0 -0.59486166 0 kegg kegg NA NA no no no no up up Vitamin digestion and absorption beta-Alanine metabolism -0.597391304 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Bile secretion 0 0 -0.506821107 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Biosynthesis of amino acids -0.744347826 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Biosynthesis of cofactors 0 0 -0.512226512 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Butanoate metabolism -0.555652174 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Calcium signaling pathway 0.530434783 0 0 kegg kegg NA NA no no no no up up Vitamin digestion and absorption cAMP signaling pathway 0.567826087 0 0 yes kegg kegg NA NA no no no no up up Vitamin digestion and absorption Carbohydrate digestion and absorption 0 0 0.582239382 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Carbon metabolism -0.782608696 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Cardiac muscle contraction 0.589565217 0 0 kegg kegg NA NA no no no no no up Vitamin digestion and absorption Cell adhesion molecules -0.672173913 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Cellular senescence -0.530434783 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption cGMP-PKG signaling pathway 0.432173913 0 0.401029601 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Circadian entrainment 0 0 -0.429343629 kegg kegg NA NA no no no no up up Vitamin digestion and absorption Circadian rhythm 0.509565217 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Complement and coagulation cascades -0.653913043 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Cytosolic DNA-sensing pathway 0 -0.477272727 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Dopaminergic synapse 0.46173913 0 0 kegg kegg NA NA no no no no up no Vitamin digestion and absorption Drug metabolism - cytochrome P450 -0.492173913 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Drug metabolism - other enzymes -0.636521739 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Endocrine resistance 0.523478261 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Endocytosis -0.566086957 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Estrogen signaling pathway 0 0 -0.51016731 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Ether lipid metabolism 0.546956522 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Fat digestion and absorption 0 0 0.411325611 yes kegg kegg NA NA no no no no up up Vitamin digestion and absorption Fatty acid degradation 0 0.429841897 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Fatty acid metabolism 0 0.438735178 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Fc epsilon RI signaling pathway 0.611304348 0 0.540797941 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Fructose and mannose metabolism -0.70173913 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Galactose metabolism -0.511304348 0.510869565 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Gap junction 0 0 -0.568339768 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Glutamatergic synapse 0 0 -0.456885457 kegg kegg NA NA no no no no up up Vitamin digestion and absorption Glutathione metabolism 0 0 -0.491119691 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Glycerolipid metabolism 0 0.459486166 0.63011583 kegg kegg NA NA no no no no no up Vitamin digestion and absorption Glycerophospholipid metabolism 0.489565217 0.419960474 0.587644788 kegg kegg NA NA no no no no no up Vitamin digestion and absorption "Glycine, serine and threonine metabolism" 0 0 -0.524324324 kegg kegg NA NA no no no no up no Vitamin digestion and absorption Glycolysis / Gluconeogenesis -0.783478261 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 0 0.608494208 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Glycosaminoglycan biosynthesis - heparan sulfate / heparin -0.48 0 0.487773488 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Glycosaminoglycan biosynthesis - keratan sulfate 0.54173913 -0.427865613 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Glycosaminoglycan degradation 0 0 0.581724582 kegg kegg NA NA no no no no no up Vitamin digestion and absorption Glycosphingolipid biosynthesis - lacto and neolacto series 0.589565217 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption GnRH secretion 0.536521739 0 0.574517375 kegg kegg NA NA no no no no up up Vitamin digestion and absorption "Growth hormone synthesis, secretion and action" 0.476521739 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Hedgehog signaling pathway 0.696521739 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption HIF-1 signaling pathway 0 -0.434782609 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Hippo signaling pathway - multiple species 0 0 0.698326898 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Histidine metabolism 0 0.593873518 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Inositol phosphate metabolism 0 0 0.528700129 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Insulin resistance 0.465217391 0 0.400772201 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Long-term depression 0.462608696 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Longevity regulating pathway 0 0 -0.465122265 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Lysine degradation 0 0 0.5001287 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Mannose type O-glycan biosynthesis 0.470434783 0 0.445559846 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Maturity onset diabetes of the young 0.563478261 0 0.441698842 kegg kegg NA NA no no no no up no Vitamin digestion and absorption Metabolism of xenobiotics by cytochrome P450 -0.52 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Mitophagy - animal 0 0 -0.442471042 kegg kegg NA NA no no no no no no Vitamin digestion and absorption mRNA surveillance pathway 0.682608696 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption mTOR signaling pathway 0 -0.443675889 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Mucin type O-glycan biosynthesis -0.479130435 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Natural killer cell mediated cytotoxicity -0.665217391 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Non-alcoholic fatty liver disease 0.650434783 -0.509881423 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Non-homologous end-joining -0.609565217 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Notch signaling pathway 0.786086957 0 0.702960103 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Other glycan degradation -0.437391304 0 0.604118404 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Other types of O-glycan biosynthesis 0 0 0.416988417 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Ovarian steroidogenesis 0 0 -0.421364221 kegg kegg NA NA no no no no up up Vitamin digestion and absorption Oxidative phosphorylation 0.625217391 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Pantothenate and CoA biosynthesis 0 0.414031621 0 kegg kegg NA NA no no no no no dn Vitamin digestion and absorption Pentose phosphate pathway -0.447826087 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Phagosome -0.552173913 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Phosphatidylinositol signaling system 0.596521739 0 0.471814672 kegg kegg NA NA no no no no no no Vitamin digestion and absorption PI3K-Akt signaling pathway 0 -0.548418972 0 yes kegg kegg NA NA no no no no up up Vitamin digestion and absorption Porphyrin and chlorophyll metabolism 0 0 -0.543114543 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Progesterone-mediated oocyte maturation 0 0 0.561904762 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Prolactin signaling pathway 0.490434783 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Protein processing in endoplasmic reticulum 0 0 -0.424710425 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Pyrimidine metabolism -0.479130435 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Regulation of actin cytoskeleton -0.443478261 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Regulation of lipolysis in adipocytes 0 0 -0.403346203 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Renin secretion 0 0 -0.483140283 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Retinol metabolism -0.47826087 0.481225296 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Retrograde endocannabinoid signaling 0.445217391 0 0 kegg kegg NA NA no no no no no up Vitamin digestion and absorption Ribosome 0.475652174 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption RNA degradation 0.62173913 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption RNA transport -0.448695652 -0.427865613 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Selenocompound metabolism 0 0.469367589 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Serotonergic synapse 0 0 -0.412612613 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Signaling pathways regulating pluripotency of stem cells 0.542608696 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Sphingolipid metabolism 0 0 0.48030888 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Sphingolipid signaling pathway 0.464347826 0 0.495495495 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Starch and sucrose metabolism 0 0.520750988 0.43011583 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Steroid biosynthesis 0.406956522 0.419960474 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Steroid hormone biosynthesis 0 0.457509881 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Sulfur metabolism -0.467826087 0 -0.447104247 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Synaptic vesicle cycle 0 0 0.421364221 kegg kegg NA NA no no no no up up Vitamin digestion and absorption Taste transduction 0 0.418972332 0.512998713 kegg kegg NA NA no no no no no up Vitamin digestion and absorption Taurine and hypotaurine metabolism 0.428695652 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption TGF-beta signaling pathway 0.58 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Thermogenesis 0.635652174 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Thyroid hormone synthesis 0 0 -0.498326898 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Tryptophan metabolism -0.426086957 0 0 kegg kegg NA NA no no no no up no Vitamin digestion and absorption Type I diabetes mellitus -0.532173913 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Type II diabetes mellitus 0 0 0.515830116 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Ubiquitin mediated proteolysis 0 0 -0.43963964 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Vasopressin-regulated water reabsorption 0.446086957 0 0 kegg kegg NA NA no no no no no no Vitamin digestion and absorption VEGF signaling pathway 0.513043478 0 0.50965251 kegg kegg NA NA no no no no no no Vitamin digestion and absorption Wnt signaling pathway 0.651304348 0 0.492921493 kegg kegg NA NA no no no no no no waistline+clinic 16:0/16:1-PC+blood 0 -0.578571429 0 clinic serum_phospholipids 0.00351 0.00283 up up no up up no waistline+clinic 16:0/18:2-PI+blood 0 -0.635714286 0 clinic serum_phospholipids 0.00351 0.269 up up no no no no waistline+clinic 16:0/22:6-PC+blood 0.488132095 0 0 clinic serum_phospholipids 0.00351 4.53E-05 up up no no up up waistline+clinic 18:0/18:1-PE+blood 0 -0.6 0 clinic serum_phospholipids 0.00351 0.00716 up up no up up no waistline+clinic 18:0/20:3-PC+blood -0.494324045 0 -0.453076923 clinic serum_phospholipids 0.00351 0.0682 up up no no up no waistline+clinic 18:0/20:3-PI+blood 0 -0.532142857 0 clinic serum_phospholipids 0.00351 0.377 up up no no no no waistline+clinic 18:0/20:4-PC+blood 0 0.525 0 clinic serum_phospholipids 0.00351 0.454 up up no no no no waistline+clinic 18:0/20:5-PC+blood 0 0.6 0 clinic serum_phospholipids 0.00351 0.17 up up no no no no waistline+clinic 18:1/18:1-PE+blood 0 -0.7 0 clinic serum_phospholipids 0.00351 1.03E-05 up up no up up no waistline+clinic 18:2-LPE+blood 0 0 0.402307692 clinic serum_phospholipids 0.00351 0.112 up up no no no no waistline+clinic 18:2n6c+blood 0 0 -0.402307692 clinic serum_fattyacid 0.00351 0.15 up up no no no no waistline+clinic 18:3n6+blood -0.801857585 0 0 clinic serum_fattyacid 0.00351 0.0463 up up no up no dn waistline+clinic 20:2/18:0-PC+blood -0.500515996 0 -0.467692308 clinic serum_phospholipids 0.00351 0.0427 up up no no up no waistline+clinic 20:3n6+blood -0.659442724 -0.557142857 0 clinic serum_fattyacid 0.00351 0.0884 up up no up no no waistline+clinic 20:4-LPC+blood 0 0.582142857 0 clinic serum_phospholipids 0.00351 0.949 up up no no no no waistline+clinic 20:4n6+blood 0 0.603571429 0 clinic serum_fattyacid 0.00351 0.133 up up no no no no waistline+clinic 4-hydroxybenzoic acid+stool 0 0 0.448898927 clinic stool_cometabolism 0.00351 0.0536 up up no no dn no waistline+clinic 8-HETE+blood 0 0.564285714 0 clinic serum_ARA 0.00351 0.741 up up no no no no waistline+clinic AA+blood 0 0.589285714 0.456153846 clinic serum_ARA 0.00351 0.212 up up no no no no waistline+clinic Akkermansia 0 0 -0.485103951 acetate-producing clinic Genus 0.00351 0.23 up up no no no no waistline+clinic Allograft rejection -0.516657256 0 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic Autoimmune thyroid disease -0.516657256 0 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic Cell adhesion molecules -0.446640316 0 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic Cellular senescence -0.509881423 0 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic Circadian entrainment 0 -0.437662338 0 clinic kegg 0.00351 NA up up no no up up waistline+clinic Creatinine+blood 0.473684211 0 0 clinic serum_choline 0.00351 0.437 up up no no no no waistline+clinic Cystine+blood 0 0 0.468461538 yes clinic serum_aminoacids 0.00351 0.00028 up up no up up no waistline+clinic Dilated cardiomyopathy 0 -0.454545455 0 clinic kegg 0.00351 NA up up no no up up waistline+clinic Endocytosis -0.431959345 0 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic Eotaxin 0 0.570175439 0 clinic serum_cytokines 0.00351 0.393 up up no no no no waistline+clinic EPA+blood 0 0.535714286 0 clinic serum_ARA 0.00351 0.212 up up no no no no waistline+clinic Gastric acid secretion 0 -0.438961039 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic Graft-versus-host disease -0.511010728 0 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic GUDCA+blood 0 0 0.500769231 clinic serum_bileacids 0.00351 0.0766 up up no no no dn waistline+clinic Hippo signaling pathway 0 -0.461038961 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic Human papillomavirus infection -0.459062676 0 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic Inflammatory mediator regulation of TRP channels 0 -0.441558442 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic L-Phenylalanine+blood 0.494324045 0 0 yes clinic serum_aminoacids 0.00351 0.0103 up up no up up no waistline+clinic L-Proline+blood 0.51496388 -0.678571429 0 yes clinic serum_aminoacids 0.00351 0.00265 up up no up up no waistline+clinic L-Tryptophan+stool 0 0 -0.431959345 clinic stool_cometabolism 0.00351 0.557 up up no no no no waistline+clinic MAPK signaling pathway 0.445511011 0.449350649 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic Measles 0 0.606493506 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic n6+blood 0 0 -0.46 clinic serum_fattyacid 0.00351 0.153 up up no no no no waistline+clinic Natural killer cell mediated cytotoxicity -0.429700734 0 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic nutriCA+stool 0 0 0.424054207 clinic stool_bileacids 0.00351 0.481 up up no no no no waistline+clinic Oscillospira 0 0.497459063 0 LPS-producing clinic Genus 0.00351 0.62 up up no no no no waistline+clinic Paraprevotella 0 -0.559666574 0 clinic Genus 0.00351 0.118 up up no no no no waistline+clinic Phenylacetic acid+stool 0 0 -0.522303783 clinic stool_cometabolism 0.00351 0.785 up up no no no no waistline+clinic Platelet activation 0 -0.451948052 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic PUFA+blood 0 0 -0.574615385 clinic serum_fattyacid 0.00351 0.212 up up no no no no waistline+clinic RANTES 0 0 0.446305419 yes clinic serum_cytokines 0.00351 0.0757 up up no no no up waistline+clinic Rap1 signaling pathway 0 -0.442857143 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic Renin secretion 0 -0.437662338 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic Roseburia 0 -0.438859097 0 butyrate-producing clinic Genus 0.00351 0.495 up up no no no no waistline+clinic Serine+blood 0.529411765 0 0 clinic serum_aminoacids 0.00351 0.942 up up no no no no waistline+clinic TCA+stool 0 -0.633259046 0 clinic stool_bileacids 0.00351 0.458 up up no no no no waistline+clinic Th17 cell differentiation 0 0.479220779 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic TMAO+blood 0 0 -0.498461538 clinic serum_choline 0.00351 0.00706 up up no up up no waistline+clinic ToFA+blood 0 0 -0.415384615 clinic serum_fattyacid 0.00351 0.0307 up up no up no dn waistline+clinic TXB2+blood 0 0.56619328 0 yes clinic serum_ARA 0.00351 0.0644 up up no dn no no waistline+clinic Type I diabetes mellitus -0.516657256 0 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic UDCA+stool 0 0 0.444381705 clinic stool_bileacids 0.00351 0.266 up up no no no no waistline+clinic UFA+blood 0 0 -0.42 clinic serum_fattyacid 0.00351 0.0444 up up no up no dn waistline+clinic Vascular smooth muscle contraction 0 -0.451948052 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic Vibrio cholerae infection 0 -0.438961039 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic Viral carcinogenesis -0.480519481 0 0 clinic kegg 0.00351 NA up up no no no no waistline+clinic Viral myocarditis -0.532467532 0 0 clinic kegg 0.00351 NA up up no no no no Weight+clinic "12,13-EPOME+blood" 0 0 0.406419082 clinic serum_ARA 0.00971 0.901 no up no no no no Weight+clinic 16:0/18:1-PC+blood 0.502579979 0 0 clinic serum_phospholipids 0.00971 6.15E-07 no up no up up up Weight+clinic 16:1+blood 0 -0.721428571 0.426153846 yes clinic serum_fattyacid 0.00971 0.0186 no up no no no dn Weight+clinic 18:0/16:0-PC+blood 0.547987616 0 0 clinic serum_phospholipids 0.00971 9.64E-07 no up no up up up Weight+clinic 18:0/20:2-PC+blood 0 0 -0.420769231 clinic serum_phospholipids 0.00971 0.733 no up no no no no Weight+clinic 18:0/20:3-PC+blood 0 0 -0.461538462 clinic serum_phospholipids 0.00971 0.0682 no up no no up no Weight+clinic 18:1/18:2-PI+blood 0 0 -0.434615385 clinic serum_phospholipids 0.00971 0.0164 no up no dn no up Weight+clinic 18:1/20:3-PC+blood 0 0 -0.443076923 clinic serum_phospholipids 0.00971 0.00872 no up no no up up Weight+clinic 20:2/18:0-PC+blood 0 0 -0.470769231 clinic serum_phospholipids 0.00971 0.0427 no up no no up no Weight+clinic 20:4-LPA+blood 0 0.557142857 0 clinic serum_phospholipids 0.00971 0.398 no up no no no no Weight+clinic "3-(3,4-dihydroxyphenyl)propionic acid+urine" -0.479876161 0 0 clinic urine_cometabolism 0.00971 0.0125 no up no up up no Weight+clinic 4-Hydroxyphenylacetic acid+urine 0 0 -0.420769231 clinic urine_cometabolism 0.00971 0.0321 no up no up up no Weight+clinic 9-HODE+blood 0 0 0.497692308 clinic serum_ARA 0.00971 0.297 no up no no no no Weight+clinic "9,10-EPOME+blood" 0 -0.562727629 0.400396415 clinic serum_ARA 0.00971 0.801 no up no no no no Weight+clinic Alzheimer disease 0 0 0.402521008 clinic kegg 0.00971 NA no up no no no no Weight+clinic Axon guidance -0.601355167 0 0 clinic kegg 0.00971 NA no up no no up up Weight+clinic B cell receptor signaling pathway -0.5256917 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic CA+stool 0 0.745454545 0 clinic stool_bileacids 0.00971 0.827 no up no no no no Weight+clinic Central carbon metabolism in cancer 0 0.574025974 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Cholinergic synapse 0 0 0.482352941 clinic kegg 0.00971 NA no up no no no no Weight+clinic Chronic myeloid leukemia -0.473743648 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Circadian entrainment 0.507622812 -0.437662338 0 clinic kegg 0.00971 NA no up no no up up Weight+clinic d18:1-14:0-SM+blood -0.521155831 0 0 clinic serum_phospholipids 0.00971 0.94 no up no no no no Weight+clinic DCA+stool 0 -0.645454545 0 clinic stool_bileacids 0.00971 0.195 no up no no no no Weight+clinic Dilated cardiomyopathy 0.425183512 0 0 clinic kegg 0.00971 NA no up no no up up Weight+clinic Ethanolamine+blood 0.566563467 0 0 clinic serum_aminoacids 0.00971 0.122 no up no up no no Weight+clinic Ferroptosis 0.531338227 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Fluid shear stress and atherosclerosis 0.436476567 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Gastric acid secretion 0.463579898 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Gastric cancer -0.422924901 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Glioma 0 0 0.430812325 clinic kegg 0.00971 NA no up no no no no Weight+clinic Glutamatergic synapse 0.470355731 0 0 clinic kegg 0.00971 NA no up no no up up Weight+clinic Glycine+blood 0.620227038 0 0 clinic serum_aminoacids 0.00971 0.00408 no up no dn no up Weight+clinic HDCA+stool 0.629411765 0 0 clinic stool_bileacids 0.00971 0.176 no up no no no no Weight+clinic Hepatitis B -0.469226426 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Hepatitis C -0.43083004 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Hippuric acid+urine -0.535603715 0 0 clinic urine_cometabolism 0.00971 0.361 no up no no no no Weight+clinic Insulin resistance -0.522303783 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic L-Aspartic acid+blood 0.620227038 0 0 yes clinic serum_aminoacids 0.00971 0.0226 no up no up up no Weight+clinic L-Phenylalanine+stool 0 0 -0.463579898 clinic stool_cometabolism 0.00971 0.398 no up no no no no Weight+clinic L-Tyrosine+stool 0 0 -0.462450593 clinic stool_cometabolism 0.00971 0.44 no up no no no no Weight+clinic LCA+stool 0 -0.627272727 0 clinic stool_bileacids 0.00971 0.314 no up no no no no Weight+clinic Legionellosis 0 0.602597403 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Leishmaniasis 0 0.52987013 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Long-term potentiation 0 0 0.560784314 clinic kegg 0.00971 NA no up no no no up Weight+clinic Malaria 0.473743648 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Measles 0 0.450649351 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic MIP-1b 0 0 0.500985222 clinic serum_cytokines 0.00971 0.632 no up no no no no Weight+clinic Neurotrophin signaling pathway -0.440993789 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic NF-kappa B signaling pathway -0.480519481 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Non-small cell lung cancer 0 0 0.417927171 clinic kegg 0.00971 NA no up no no no no Weight+clinic Oocyte meiosis 0 0 0.495798319 clinic kegg 0.00971 NA no up no no no no Weight+clinic Oxytocin signaling pathway 0.456804065 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic P-hydroxyhippuric acid+urine -0.484004128 0 0 clinic urine_cometabolism 0.00971 0.436 no up no no no no Weight+clinic Pancreatic cancer -0.466967815 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic PI3K-Akt signaling pathway 0 0.618181818 0 yes clinic kegg 0.00971 NA no up no no up up Weight+clinic Platelet activation 0.469226426 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Prostate cancer -0.521174478 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic RANTES 0 0 0.519211823 yes clinic serum_cytokines 0.00971 0.0757 no up no no no up Weight+clinic Ras signaling pathway -0.479390175 0 0.477310924 yes clinic kegg 0.00971 NA no up no no up up Weight+clinic Renin secretion 0.462450593 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Retrograde endocannabinoid signaling 0 0 0.433333333 clinic kegg 0.00971 NA no up no no no up Weight+clinic Roseburia 0.548418972 0 0 butyrate-producing clinic Genus 0.00971 0.495 no up no no no no Weight+clinic Ruminococcus 0.449604743 0 0 acetate-producing clinic Genus 0.00971 0.335 no up no no no no Weight+clinic Serotonergic synapse 0.559570864 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Signaling pathways regulating pluripotency of stem cells 0 0 0.433613445 clinic kegg 0.00971 NA no up no no no no Weight+clinic Small cell lung cancer -0.427442123 0 0 clinic kegg 0.00971 NA no up no no no up Weight+clinic T cell receptor signaling pathway -0.445511011 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic TLCA+stool -0.543344105 0 0 clinic stool_bileacids 0.00971 0.243 no up no no no no Weight+clinic Transcriptional misregulation in cancer -0.583286279 0 0 clinic kegg 0.00971 NA no up no no no no Weight+clinic Vibrio cholerae infection 0.446640316 0 0 clinic kegg 0.00971 NA no up no no no no Wnt signaling pathway 2-Oxocarboxylic acid metabolism 0 0.754940711 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Adrenergic signaling in cardiomyocytes 0.523478261 0.666007905 0.43037323 kegg kegg NA NA no no no no no up Wnt signaling pathway Akkermansia -0.428387973 0 0 acetate-producing kegg Genus NA 0.23 no no no no no no Wnt signaling pathway "Alanine, aspartate and glutamate metabolism" -0.534782609 -0.875494071 -0.665637066 kegg kegg NA NA no no no no no no Wnt signaling pathway alpha-Linolenic acid metabolism -0.657391304 -0.597826087 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Amino sugar and nucleotide sugar metabolism -0.66173913 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Aminoacyl-tRNA biosynthesis -0.465217391 0.552371542 0 kegg kegg NA NA no no no no no no Wnt signaling pathway AMPK signaling pathway 0 0 -0.475933076 kegg kegg NA NA no no no no no no Wnt signaling pathway Antifolate resistance 0 0.53458498 0.536164736 kegg kegg NA NA no no no no no no Wnt signaling pathway Apoptosis 0 -0.707509881 -0.468468468 kegg kegg NA NA no no no no no no Wnt signaling pathway Arachidonic acid metabolism 0 0 -0.599485199 kegg kegg NA NA no no no no no no Wnt signaling pathway Arginine and proline metabolism -0.574782609 -0.821146245 -0.414671815 kegg kegg NA NA no no no no up no Wnt signaling pathway Arginine biosynthesis -0.550434783 -0.906126482 -0.745945946 kegg kegg NA NA no no no no no no Wnt signaling pathway Ascorbate and aldarate metabolism 0 0.443675889 0.405148005 kegg kegg NA NA no no no no no no Wnt signaling pathway Autophagy - animal 0 -0.631422925 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Autophagy - other 0 0 0.644015444 kegg kegg NA NA no no no no no no Wnt signaling pathway Basal transcription factors 0 0.563241107 0.674646075 kegg kegg NA NA no no no no no no Wnt signaling pathway Base excision repair 0 0.545454545 0.413642214 kegg kegg NA NA no no no no no no Wnt signaling pathway beta-Alanine metabolism -0.585217391 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Biosynthesis of amino acids -0.73826087 -0.833003953 -0.787902188 kegg kegg NA NA no no no no no no Wnt signaling pathway Biosynthesis of cofactors 0 0.47826087 -0.512998713 kegg kegg NA NA no no no no no no Wnt signaling pathway Biosynthesis of unsaturated fatty acids -0.42173913 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Butanoate metabolism 0 0.661067194 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Calcium signaling pathway 0.734782609 0.555335968 0.461518662 kegg kegg NA NA no no no no up up Wnt signaling pathway cAMP signaling pathway 0.597391304 0 0 yes kegg kegg NA NA no no no no up up Wnt signaling pathway Carbon metabolism -0.644347826 0 -0.562162162 kegg kegg NA NA no no no no no no Wnt signaling pathway Cardiac muscle contraction 0.71826087 0.679841897 0.497297297 kegg kegg NA NA no no no no no up Wnt signaling pathway Cell cycle 0 0.805335968 0.776576577 kegg kegg NA NA no no no no no no Wnt signaling pathway Cellular senescence 0 -0.454545455 0 kegg kegg NA NA no no no no no no Wnt signaling pathway cGMP-PKG signaling pathway 0 -0.871541502 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Chemokine signaling pathway 0 -0.682806324 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Citrate cycle (TCA cycle) 0 0.625494071 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Collinsella 0 0 -0.435292927 kegg Genus NA 0.128 no no no no no no Wnt signaling pathway Cysteine and methionine metabolism 0 0.589920949 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Cytokine-cytokine receptor interaction 0 -0.421936759 0 kegg kegg NA NA no no no no no no Wnt signaling pathway DNA replication 0 0.778656126 0.55006435 kegg kegg NA NA no no no no no no Wnt signaling pathway Drug metabolism - cytochrome P450 -0.44173913 0.697628458 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Drug metabolism - other enzymes -0.562608696 0.659090909 0 kegg kegg NA NA no no no no no no Wnt signaling pathway EGFR tyrosine kinase inhibitor resistance 0 0.596837945 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Endocrine resistance 0.429565217 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Endocytosis 0 -0.469367589 0 kegg kegg NA NA no no no no no no Wnt signaling pathway ErbB signaling pathway 0 0 0.63963964 kegg kegg NA NA no no no no no no Wnt signaling pathway Ether lipid metabolism 0.75826087 0.581027668 0.566537967 kegg kegg NA NA no no no no no no Wnt signaling pathway Fanconi anemia pathway 0 0.4743083 0.564993565 kegg kegg NA NA no no no no no no Wnt signaling pathway Fatty acid biosynthesis -0.524347826 -0.850790514 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Fatty acid degradation -0.663478261 -0.635375494 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Fatty acid metabolism -0.692173913 -0.710474308 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Ferroptosis 0 0 -0.588416988 kegg kegg NA NA no no no no no no Wnt signaling pathway Folate biosynthesis 0 0.76284585 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Fructose and mannose metabolism -0.660869565 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Galactose metabolism -0.572173913 -0.43972332 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Glutathione metabolism 0 0.496047431 -0.577863578 kegg kegg NA NA no no no no no no Wnt signaling pathway Glycerolipid metabolism 0 0 0.701158301 kegg kegg NA NA no no no no no up Wnt signaling pathway Glycerophospholipid metabolism 0 0 0.752380952 kegg kegg NA NA no no no no no up Wnt signaling pathway "Glycine, serine and threonine metabolism" 0 0 -0.525353925 kegg kegg NA NA no no no no up no Wnt signaling pathway Glycolysis / Gluconeogenesis -0.70173913 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0 -0.535573123 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0 0.742094862 0.629343629 kegg kegg NA NA no no no no no no Wnt signaling pathway Glycosaminoglycan biosynthesis - keratan sulfate 0.753913043 0.60770751 0.601029601 kegg kegg NA NA no no no no no no Wnt signaling pathway Glycosaminoglycan degradation 0 -0.502964427 0 kegg kegg NA NA no no no no no up Wnt signaling pathway Glycosphingolipid biosynthesis - ganglio series 0 0.499011858 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Glycosphingolipid biosynthesis - lacto and neolacto series 0.697391304 0 0.52998713 kegg kegg NA NA no no no no no no Wnt signaling pathway Glyoxylate and dicarboxylate metabolism -0.606086957 -0.920948617 -0.6998713 kegg kegg NA NA no no no no no no Wnt signaling pathway HIF-1 signaling pathway 0 0.494071146 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Homologous recombination 0 0 0.462805663 kegg kegg NA NA no no no no no no Wnt signaling pathway Inositol phosphate metabolism 0 0 0.657400257 kegg kegg NA NA no no no no no no Wnt signaling pathway Linoleic acid metabolism 0 0 0.431145431 kegg kegg NA NA no no no no no no Wnt signaling pathway Lysine degradation 0 0.508893281 0.844272844 kegg kegg NA NA no no no no no no Wnt signaling pathway Lysosome 0 -0.644268775 -0.418275418 kegg kegg NA NA no no no no no no Wnt signaling pathway Mannose type O-glycan biosynthesis 0.750434783 0.526679842 0.877477477 kegg kegg NA NA no no no no no no Wnt signaling pathway MAPK signaling pathway 0 0 0.54980695 kegg kegg NA NA no no no no no no Wnt signaling pathway Metabolism of xenobiotics by cytochrome P450 -0.506956522 0.630434783 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Mismatch repair 0 0.502964427 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Mitophagy - animal 0.413913043 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway mRNA surveillance pathway 0.737391304 0.87055336 0.884427284 kegg kegg NA NA no no no no no no Wnt signaling pathway mTOR signaling pathway 0 0.579051383 0 kegg kegg NA NA no no no no no no Wnt signaling pathway N-Glycan biosynthesis 0 0.928853755 0.612612613 kegg kegg NA NA no no no no no no Wnt signaling pathway Necroptosis 0 0 -0.577348777 kegg kegg NA NA no no no no no no Wnt signaling pathway Neuroactive ligand-receptor interaction 0 -0.631422925 -0.51016731 kegg kegg NA NA no no no up up up Wnt signaling pathway NF-kappa B signaling pathway 0 -0.618577075 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Nicotinate and nicotinamide metabolism -0.510434783 -0.87055336 -0.490862291 kegg kegg NA NA no no no no no no Wnt signaling pathway Nitrogen metabolism -0.530434783 -0.885375494 -0.671299871 kegg kegg NA NA no no no no no no Wnt signaling pathway Non-homologous end-joining -0.5 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Nucleotide excision repair 0 0.634387352 0 kegg kegg NA NA no no no no no no Wnt signaling pathway One carbon pool by folate 0 0.714426877 0.598970399 kegg kegg NA NA no no no no no no Wnt signaling pathway Oocyte meiosis 0 0.515810277 0.620849421 kegg kegg NA NA no no no no no no Wnt signaling pathway Other glycan degradation -0.443478261 0 0.503989704 kegg kegg NA NA no no no no no no Wnt signaling pathway Other types of O-glycan biosynthesis 0.432173913 0.423913043 0.792277992 kegg kegg NA NA no no no no no no Wnt signaling pathway Oxidative phosphorylation 0.707826087 0.639328063 0.404890605 kegg kegg NA NA no no no no no no Wnt signaling pathway p53 signaling pathway 0 0 0.430888031 kegg kegg NA NA no no no no no no Wnt signaling pathway Pantothenate and CoA biosynthesis 0 -0.840909091 -0.464864865 kegg kegg NA NA no no no no no dn Wnt signaling pathway Paraprevotella 0 0.437974162 0 kegg Genus NA 0.118 no no no no no no Wnt signaling pathway Pentose and glucuronate interconversions 0 0.799407115 0.461003861 kegg kegg NA NA no no no no no no Wnt signaling pathway Pentose phosphate pathway 0 -0.757905138 -0.685714286 kegg kegg NA NA no no no no no no Wnt signaling pathway Peroxisome -0.573043478 -0.807312253 -0.686486486 kegg kegg NA NA no no no no no no Wnt signaling pathway Phagosome -0.46173913 -0.543478261 -0.527413127 kegg kegg NA NA no no no no no no Wnt signaling pathway Phenylalanine metabolism 0 0.559288538 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Phosphatidylinositol signaling system 0.690434783 0.540513834 0.887001287 kegg kegg NA NA no no no no no no Wnt signaling pathway Phospholipase D signaling pathway 0 -0.576086957 0 kegg kegg NA NA no no no no up up Wnt signaling pathway Porphyrin and chlorophyll metabolism 0 0 -0.545688546 kegg kegg NA NA no no no no no no Wnt signaling pathway PPAR signaling pathway -0.495652174 -0.791501976 -0.406177606 kegg kegg NA NA no no no no no no Wnt signaling pathway Propanoate metabolism -0.423478261 0.508893281 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Proteasome 0 0.443675889 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Protein export 0.437391304 0.727272727 0.690862291 kegg kegg NA NA no no no no no no Wnt signaling pathway Protein processing in endoplasmic reticulum 0 0.838932806 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Purine metabolism 0 0.443675889 -0.432689833 kegg kegg NA NA no no no no no no Wnt signaling pathway Pyrimidine metabolism -0.675652174 0.639328063 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Pyruvate metabolism 0 0.634387352 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Ras signaling pathway 0.489565217 0.791501976 0.826512227 yes kegg kegg NA NA no no no no up up Wnt signaling pathway Retinol metabolism -0.635652174 0 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Ribosome 0.614782609 0.571146245 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Ribosome biogenesis in eukaryotes 0 0.720355731 0.727670528 kegg kegg NA NA no no no no no no Wnt signaling pathway RNA degradation 0.765217391 0.931818182 0.880566281 kegg kegg NA NA no no no no no no Wnt signaling pathway RNA polymerase 0 0.814229249 0.610810811 kegg kegg NA NA no no no no no no Wnt signaling pathway RNA transport 0 0.539525692 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Selenocompound metabolism 0 0 0.545431145 kegg kegg NA NA no no no no no no Wnt signaling pathway Sphingolipid signaling pathway 0 0 0.51994852 kegg kegg NA NA no no no no no no Wnt signaling pathway Spliceosome 0 0 0.67001287 kegg kegg NA NA no no no no no no Wnt signaling pathway Starch and sucrose metabolism -0.523478261 -0.777667984 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Sulfur metabolism 0 0 -0.681853282 kegg kegg NA NA no no no no no no Wnt signaling pathway Synthesis and degradation of ketone bodies 0 0.526679842 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Taurine and hypotaurine metabolism 0 0 0.457400257 kegg kegg NA NA no no no no no no Wnt signaling pathway Terpenoid backbone biosynthesis 0 0 0.611068211 kegg kegg NA NA no no no no no no Wnt signaling pathway Thiamine metabolism 0 0.454545455 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Tryptophan metabolism -0.409565217 0 0 kegg kegg NA NA no no no no up no Wnt signaling pathway Tyrosine metabolism -0.427826087 0.529644269 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Ubiquinone and other terpenoid-quinone biosynthesis 0 0.52173913 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Ubiquitin mediated proteolysis 0.505217391 0.484189723 0 kegg kegg NA NA no no no no no no Wnt signaling pathway "Valine, leucine and isoleucine degradation" 0 0.626482213 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Various types of N-glycan biosynthesis 0 0.827075099 0.565508366 kegg kegg NA NA no no no no no no Wnt signaling pathway Vascular smooth muscle contraction 0.64 0.476284585 0 kegg kegg NA NA no no no no no no Wnt signaling pathway Viral protein interaction with cytokine and cytokine receptor 0 -0.518774704 0 kegg kegg NA NA no no no no no no Yersinia infection Adherens junction 0.584347826 0 0.764221364 kegg kegg NA NA no no no no no no Yersinia infection Adrenergic signaling in cardiomyocytes 0 -0.527667984 0 kegg kegg NA NA no no no no no up Yersinia infection AGE-RAGE signaling pathway in diabetic complications 0 0.509881423 0 kegg kegg NA NA no no no no no no Yersinia infection Aldosterone synthesis and secretion 0 -0.681818182 0 kegg kegg NA NA no no no no up up Yersinia infection Aminoacyl-tRNA biosynthesis 0 -0.442687747 0 kegg kegg NA NA no no no no no no Yersinia infection Amphetamine addiction 0 -0.770750988 0 kegg kegg NA NA no no no no no no Yersinia infection AMPK signaling pathway -0.489565217 -0.725296443 0 kegg kegg NA NA no no no no no no Yersinia infection Amyotrophic lateral sclerosis 0 -0.473320158 0 kegg kegg NA NA no no no no no no Yersinia infection Antifolate resistance 0 -0.517786561 0 kegg kegg NA NA no no no no no no Yersinia infection Apelin signaling pathway -0.554782609 -0.432806324 0 kegg kegg NA NA no no no no no no Yersinia infection Apoptosis 0.816521739 0.723320158 0.734877735 kegg kegg NA NA no no no no no no Yersinia infection Apoptosis - multiple species -0.627826087 -0.485177866 -0.588159588 kegg kegg NA NA no no no no no no Yersinia infection Arginine and proline metabolism 0.443478261 0.514822134 0 kegg kegg NA NA no no no no up no Yersinia infection Arginine biosynthesis 0 0.472332016 0 kegg kegg NA NA no no no no no no Yersinia infection Autophagy - other -0.439130435 0 -0.471299871 kegg kegg NA NA no no no no no no Yersinia infection B cell receptor signaling pathway 0 0.568181818 0 kegg kegg NA NA no no no no no no Yersinia infection Bacterial invasion of epithelial cells 0.68 0 0.756241956 kegg kegg NA NA no no no no no no Yersinia infection Basal transcription factors -0.62173913 -0.825098814 -0.567052767 kegg kegg NA NA no no no no no no Yersinia infection Base excision repair -0.654782609 -0.704545455 -0.53951094 kegg kegg NA NA no no no no no no Yersinia infection Biosynthesis of amino acids 0.405217391 0.773715415 0.417503218 kegg kegg NA NA no no no no no no Yersinia infection Biosynthesis of cofactors 0 -0.718379447 0 kegg kegg NA NA no no no no no no Yersinia infection C-type lectin receptor signaling pathway 0 0.522727273 0 kegg kegg NA NA no no no no no no Yersinia infection Carbon metabolism 0 0.529644269 0 kegg kegg NA NA no no no no no no Yersinia infection Cell adhesion molecules 0 0.759881423 0.458429858 kegg kegg NA NA no no no no no no Yersinia infection Cell cycle -0.524347826 -0.796442688 -0.422393822 kegg kegg NA NA no no no no no no Yersinia infection Cellular senescence 0 0.705533597 0 kegg kegg NA NA no no no no no no Yersinia infection cGMP-PKG signaling pathway 0 0.776679842 0 kegg kegg NA NA no no no no no no Yersinia infection Chemokine signaling pathway 0.471304348 0.713438735 0.592020592 kegg kegg NA NA no no no no no no Yersinia infection Cholesterol metabolism 0 0.62055336 0 yes kegg kegg NA NA no no no no no up Yersinia infection Circadian rhythm 0 -0.853754941 -0.536936937 kegg kegg NA NA no no no no no no Yersinia infection Cocaine addiction 0 -0.472332016 0 kegg kegg NA NA no no no no no no Yersinia infection Collecting duct acid secretion 0.460869565 0 0 kegg kegg NA NA no no no no no no Yersinia infection Complement and coagulation cascades 0.433043478 0.713438735 0.480566281 kegg kegg NA NA no no no no no no Yersinia infection Cortisol synthesis and secretion 0 -0.650197628 0 kegg kegg NA NA no no no no no up Yersinia infection Cushing syndrome -0.417391304 -0.804347826 0 kegg kegg NA NA no no no no no up Yersinia infection Cytokine-cytokine receptor interaction 0 0 0.43037323 kegg kegg NA NA no no no no no no Yersinia infection DNA replication -0.495652174 -0.57312253 -0.446074646 kegg kegg NA NA no no no no no no Yersinia infection Dopaminergic synapse 0 -0.435770751 0 kegg kegg NA NA no no no no up no Yersinia infection ECM-receptor interaction -0.497391304 0 0 kegg kegg NA NA no no no no up up Yersinia infection EGFR tyrosine kinase inhibitor resistance -0.583478261 0 0 kegg kegg NA NA no no no no no no Yersinia infection Eggerthella 0 -0.441395835 0 kegg Genus NA 0.912 no no no no no no Yersinia infection Endocrine and other factor-regulated calcium reabsorption 0 -0.501976285 0 kegg kegg NA NA no no no no no no Yersinia infection Endocrine resistance 0 -0.555335968 0 kegg kegg NA NA no no no no no no Yersinia infection Endocytosis 0.497391304 0.769762846 0.446589447 kegg kegg NA NA no no no no no no Yersinia infection Epithelial cell signaling in Helicobacter pylori infection 0.631304348 0.783596838 0.520720721 kegg kegg NA NA no no no no no no Yersinia infection Estrogen signaling pathway 0 -0.5256917 0 kegg kegg NA NA no no no no no no Yersinia infection Ether lipid metabolism 0 -0.682806324 0 kegg kegg NA NA no no no no no no Yersinia infection Eubacterium 0 0 -0.456340257 kegg Genus NA 0.0692 no no no no no no Yersinia infection Fanconi anemia pathway -0.494782609 -0.659090909 -0.544658945 kegg kegg NA NA no no no no no no Yersinia infection Fat digestion and absorption 0 0.610671937 0 yes kegg kegg NA NA no no no no up up Yersinia infection Fatty acid biosynthesis 0 0.505928854 0 kegg kegg NA NA no no no no no no Yersinia infection Fc epsilon RI signaling pathway 0 0.652173913 0 kegg kegg NA NA no no no no no no Yersinia infection Fc gamma R-mediated phagocytosis 0.711304348 0.774703557 0.413127413 kegg kegg NA NA no no no no no no Yersinia infection Focal adhesion 0.539130435 0 0.588159588 kegg kegg NA NA no no no no up up Yersinia infection Gastric acid secretion 0.412173913 0 0.68983269 kegg kegg NA NA no no no no no no Yersinia infection Glucagon signaling pathway -0.545217391 -0.746047431 -0.411068211 kegg kegg NA NA no no no no no no Yersinia infection Glutathione metabolism -0.429565217 -0.584980237 0 kegg kegg NA NA no no no no no no Yersinia infection Glycerophospholipid metabolism -0.443478261 0 0 kegg kegg NA NA no no no no no up Yersinia infection "Glycine, serine and threonine metabolism" 0 -0.596837945 0 kegg kegg NA NA no no no no up no Yersinia infection Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.44173913 0 0 kegg kegg NA NA no no no no no no Yersinia infection Glycosaminoglycan degradation 0.613043478 0.575098814 0 kegg kegg NA NA no no no no no up Yersinia infection Glycosphingolipid biosynthesis - ganglio series 0 -0.517786561 0 kegg kegg NA NA no no no no no no Yersinia infection Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -0.431304348 -0.613636364 0 kegg kegg NA NA no no no no no no Yersinia infection Glyoxylate and dicarboxylate metabolism 0 0.501976285 0 kegg kegg NA NA no no no no no no Yersinia infection GnRH signaling pathway 0 -0.571146245 0 kegg kegg NA NA no no no no no no Yersinia infection Hedgehog signaling pathway 0 -0.662055336 0 kegg kegg NA NA no no no no no no Yersinia infection HIF-1 signaling pathway -0.597391304 0 0 kegg kegg NA NA no no no no no no Yersinia infection Hippo signaling pathway 0 0 0.602831403 kegg kegg NA NA no no no no no no Yersinia infection Homologous recombination 0 -0.523715415 -0.606177606 kegg kegg NA NA no no no no no no Yersinia infection Huntington disease 0 -0.416996047 0 kegg kegg NA NA no no no no no no Yersinia infection IL-17 signaling pathway 0.546956522 0.749011858 0 kegg kegg NA NA no no no no no no Yersinia infection Inflammatory mediator regulation of TRP channels 0 -0.565217391 0 kegg kegg NA NA no no no no no no Yersinia infection Insulin secretion -0.415652174 -0.619565217 0 yes kegg kegg NA NA no no no no up up Yersinia infection Insulin signaling pathway -0.613913043 -0.437747036 0 kegg kegg NA NA no no no no no no Yersinia infection Leukocyte transendothelial migration 0.726956522 0.501976285 0.775032175 kegg kegg NA NA no no no no no no Yersinia infection Longevity regulating pathway -0.443478261 -0.448616601 0 kegg kegg NA NA no no no no no no Yersinia infection Lysine degradation -0.58 -0.638339921 -0.473359073 kegg kegg NA NA no no no no no no Yersinia infection Lysosome 0.662608696 0.826086957 0.465122265 kegg kegg NA NA no no no no no no Yersinia infection Mannose type O-glycan biosynthesis 0 -0.52173913 0 kegg kegg NA NA no no no no no no Yersinia infection Maturity onset diabetes of the young 0 -0.489130435 0 kegg kegg NA NA no no no no up no Yersinia infection Melanogenesis 0 -0.48715415 0 kegg kegg NA NA no no no no no no Yersinia infection Mismatch repair 0 -0.485177866 0 kegg kegg NA NA no no no no no no Yersinia infection Mitophagy - animal 0 -0.441699605 0 kegg kegg NA NA no no no no no no Yersinia infection mRNA surveillance pathway -0.428695652 -0.754940711 -0.441184041 kegg kegg NA NA no no no no no no Yersinia infection mTOR signaling pathway -0.602608696 -0.437747036 0 kegg kegg NA NA no no no no no no Yersinia infection Mucin type O-glycan biosynthesis 0 0 -0.418018018 kegg kegg NA NA no no no no no no Yersinia infection N-Glycan biosynthesis -0.606956522 -0.631422925 0 kegg kegg NA NA no no no no no no Yersinia infection Natural killer cell mediated cytotoxicity 0.507826087 0.742094862 0 kegg kegg NA NA no no no no no no Yersinia infection Neuroactive ligand-receptor interaction 0.66173913 0.734189723 0.461518662 kegg kegg NA NA no no no up up up Yersinia infection Neutrophil extracellular trap formation 0.82 0.862648221 0.626254826 kegg kegg NA NA no no no no no no Yersinia infection Nicotinate and nicotinamide metabolism 0.419130435 0.601778656 0 kegg kegg NA NA no no no no no no Yersinia infection Nitrogen metabolism 0 0.416007905 0 kegg kegg NA NA no no no no no no Yersinia infection NOD-like receptor signaling pathway 0.497391304 0.489130435 0 kegg kegg NA NA no no no no no no Yersinia infection Nucleotide excision repair -0.489565217 -0.649209486 -0.442471042 kegg kegg NA NA no no no no no no Yersinia infection Olfactory transduction 0.535652174 0.732213439 0 kegg kegg NA NA no no no no no no Yersinia infection One carbon pool by folate -0.422608696 -0.644268775 0 kegg kegg NA NA no no no no no no Yersinia infection Osteoclast differentiation 0.712173913 0.698616601 0 kegg kegg NA NA no no no no no no Yersinia infection Other types of O-glycan biosynthesis -0.597391304 -0.71541502 -0.559073359 kegg kegg NA NA no no no no no no Yersinia infection Oxytocin signaling pathway 0.591304348 0.470355731 0.61956242 kegg kegg NA NA no no no no no no Yersinia infection p53 signaling pathway -0.645217391 -0.551383399 -0.725611326 kegg kegg NA NA no no no no no no Yersinia infection Pantothenate and CoA biosynthesis 0.482608696 0.541501976 0 kegg kegg NA NA no no no no no dn Yersinia infection "Parathyroid hormone synthesis, secretion and action" 0 -0.416007905 0 kegg kegg NA NA no no no no no no Yersinia infection Pathogenic Escherichia coli infection 0.875652174 0.904150198 0.846074646 kegg kegg NA NA no no no no no no Yersinia infection Pathways of neurodegeneration - multiple diseases 0 -0.446640316 0 kegg kegg NA NA no no no no no no Yersinia infection Pentose and glucuronate interconversions 0 -0.492094862 0 kegg kegg NA NA no no no no no no Yersinia infection Pentose phosphate pathway 0.66 0.852766798 0 kegg kegg NA NA no no no no no no Yersinia infection Peroxisome 0 0.43972332 0 kegg kegg NA NA no no no no no no Yersinia infection Pertussis 0.639130435 0.799407115 0.454568855 kegg kegg NA NA no no no no no dn Yersinia infection Phagosome 0.51826087 0.863636364 0.64015444 kegg kegg NA NA no no no no no no Yersinia infection Phosphatidylinositol signaling system -0.435652174 -0.60770751 -0.416473616 kegg kegg NA NA no no no no no no Yersinia infection Platelet activation 0.520869565 0 0.758301158 kegg kegg NA NA no no no no no no Yersinia infection Platinum drug resistance -0.6 -0.535573123 -0.585585586 kegg kegg NA NA no no no no no no Yersinia infection Porphyrin and chlorophyll metabolism 0 -0.588932806 0 kegg kegg NA NA no no no no no no Yersinia infection PPAR signaling pathway 0 0.570158103 0 kegg kegg NA NA no no no no no no Yersinia infection Progesterone-mediated oocyte maturation 0 -0.456521739 0 kegg kegg NA NA no no no no no no Yersinia infection Prolactin signaling pathway 0 0.472332016 0 kegg kegg NA NA no no no no no no Yersinia infection Protein export -0.612173913 -0.459486166 0 kegg kegg NA NA no no no no no no Yersinia infection Protein processing in endoplasmic reticulum -0.576521739 -0.736166008 0 kegg kegg NA NA no no no no no no Yersinia infection Proximal tubule bicarbonate reclamation 0 -0.522727273 0 kegg kegg NA NA no no no no no no Yersinia infection Purine metabolism -0.544347826 -0.628458498 0 kegg kegg NA NA no no no no no no Yersinia infection Pyrimidine metabolism 0 -0.495059289 -0.501415701 kegg kegg NA NA no no no no no no Yersinia infection Pyruvate metabolism 0 -0.488142292 0 kegg kegg NA NA no no no no no no Yersinia infection Rap1 signaling pathway 0.67826087 0 0.836808237 kegg kegg NA NA no no no no no no Yersinia infection Regulation of actin cytoskeleton 0.570434783 0 0.425740026 kegg kegg NA NA no no no no no no Yersinia infection Renin secretion 0 -0.433794466 0 kegg kegg NA NA no no no no no no Yersinia infection Renin-angiotensin system 0.517391304 0.747035573 0 kegg kegg NA NA no no no no no no Yersinia infection Ribosome -0.564347826 0 0 kegg kegg NA NA no no no no no no Yersinia infection Ribosome biogenesis in eukaryotes -0.717391304 -0.745059289 -0.497297297 kegg kegg NA NA no no no no no no Yersinia infection RNA degradation -0.443478261 -0.644268775 -0.405405405 kegg kegg NA NA no no no no no no Yersinia infection RNA polymerase -0.79826087 -0.788537549 0 kegg kegg NA NA no no no no no no Yersinia infection RNA transport -0.426956522 0 0 kegg kegg NA NA no no no no no no Yersinia infection Salmonella infection 0.706956522 0.772727273 0.691119691 kegg kegg NA NA no no no no no no Yersinia infection Selenocompound metabolism -0.57826087 -0.612648221 -0.555469755 kegg kegg NA NA no no no no no no Yersinia infection Signaling pathways regulating pluripotency of stem cells 0 -0.532608696 0 kegg kegg NA NA no no no no no no Yersinia infection Sphingolipid metabolism 0.58173913 0 0 kegg kegg NA NA no no no no no no Yersinia infection Sphingolipid signaling pathway 0 0.535573123 0 kegg kegg NA NA no no no no no no Yersinia infection Spinocerebellar ataxia -0.413043478 -0.648221344 0 kegg kegg NA NA no no no no no no Yersinia infection Spliceosome -0.65826087 -0.564229249 -0.554954955 kegg kegg NA NA no no no no no no Yersinia infection Starch and sucrose metabolism 0.604347826 0.503952569 0 kegg kegg NA NA no no no no no no Yersinia infection Steroid biosynthesis -0.505217391 -0.43972332 0 kegg kegg NA NA no no no no no no Yersinia infection Synaptic vesicle cycle 0.610434783 0.770750988 0 kegg kegg NA NA no no no no up up Yersinia infection Synthesis and degradation of ketone bodies 0 -0.623517787 0 kegg kegg NA NA no no no no no no Yersinia infection Taste transduction 0 -0.557312253 0 kegg kegg NA NA no no no no no up Yersinia infection Terpenoid backbone biosynthesis -0.422608696 -0.507905138 0 kegg kegg NA NA no no no no no no Yersinia infection Thiamine metabolism 0 -0.471343874 -0.418790219 kegg kegg NA NA no no no no no no Yersinia infection Thyroid hormone signaling pathway 0.468695652 0 0.572972973 kegg kegg NA NA no no no no no no Yersinia infection Thyroid hormone synthesis -0.557391304 -0.508893281 0 kegg kegg NA NA no no no no no no Yersinia infection Tight junction 0.533043478 0 0.623423423 kegg kegg NA NA no no no no no no Yersinia infection Toll-like receptor signaling pathway 0 0.60770751 0.420592021 yes kegg kegg NA NA no no no no no no Yersinia infection Type I diabetes mellitus 0 0.709486166 0.400514801 kegg kegg NA NA no no no no no no Yersinia infection Ubiquitin mediated proteolysis -0.467826087 -0.576086957 0 kegg kegg NA NA no no no no no no Yersinia infection Various types of N-glycan biosynthesis -0.488695652 -0.601778656 0 kegg kegg NA NA no no no no no no Yersinia infection Vasopressin-regulated water reabsorption 0 -0.422924901 0 kegg kegg NA NA no no no no no no Yersinia infection Vibrio cholerae infection 0.519130435 0 0.784813385 kegg kegg NA NA no no no no no no Yersinia infection Viral protein interaction with cytokine and cytokine receptor 0 0.495059289 0.44993565 kegg kegg NA NA no no no no no no Yersinia infection Wnt signaling pathway 0 -0.617588933 0 kegg kegg NA NA no no no no no no